Miracle-dz/UniFAR-FTUs huggingface dataset:
In vitro antimicrobial activity of S-649266, a catechol-substituted siderophore cephalosporin, when tested against non-fermenting Gram-negative bacteria.

OBJECTIVES S-649266 is a parenteral siderophore cephalosporin antibiotic with a catechol moiety on its side chain. The in vitro antimicrobial activity of S-649266 against non-fermenting Gram-negative bacteria was evaluated and compared with the activities of meropenem, levofloxacin, cefepime, ceftazidime and piperacillin/tazobactam. METHODS MIC values of S-649266 were determined in Mueller-Hinton broth or Iso-Sensitest broth supplemented with apo-transferrin. RESULTS S-649266 showed potent in vitro activity against the non-fermenting Gram-negative bacteria Acinetobacter baumannii, Pseudomonas aeruginosa and Stenotrophomonas maltophilia, including MDR strains such as carbapenem-resistant A. baumannii and metallo-β-lactamase-producing P. aeruginosa. MIC90s of S-649266 for A. baumannii, P. aeruginosa and S. maltophilia were 2, 1 and 0.5 mg/L, respectively, whereas MIC90s of meropenem were >16 mg/L. S-649266 showed potent in vitro activities against A. baumannii producing carbapenemases such as OXA-type β-lactamases, and P. aeruginosa producing metallo-β-lactamases such as IMP type and VIM type. MIC90 values for these A. baumannii strains and P. aeruginosa strains were 8 and 4 mg/L, respectively. CONCLUSIONS S-649266 is a novel antibiotic with potent in vitro activity against a range of non-fermenting Gram-negative bacteria, including MDR strains.
Learning strategies of nascent entrepreneurs

This research utilizes a longitudinal methodology to study the entrepreneurial learning strategies of a representative sample (n= 173) of nascent entrepreneurs in Sweden. We examine Sarasvathy’s theory of effectuation with respect to six different learning strategies and their effect on the progression of start-up processes. The results show that the progression of the start-up process, as represented by the number of gestation activities undertaken during each time period, is systematically related to the nascent entrepreneur’s learning strategy. The analysis covers 24 months, and findings indicate that learning strategies associated with effectuation processes have positive effects on the progression of the start-up process. We also found positive effects from persistent learning strategies in the progression of the start up process.
Designing Data Governance Structure: An Organizational Perspective

High quality data is a key source of business value, but data quality issues in organizations are often addressed inadequately and pertinent Data Governance (DG) is called for. This paper focuses on the accountability aspect of data governance: the assignment of decision rights and responsibilities pertaining to data management. We follow the design science approach and examine how Agile Governance Model (AGM) can be used as the basis of designing a pertinent governance structure for the organizational arrangement of data governance accountabilities. We distinguish common data management roles based on the literature, analyze the organizational coverage of these data governance roles, and demonstrate how AGM can be used to ensure that requisite accountabilities will be addressed throughout the enterprise at the right organizational levels and aspectual loci.
Central Nervous System Pharmacokinetics of the Mdr1 P-Glycoprotein Substrate CP-615,003: Intersite Differences and Implications for Human Receptor Occupancy Projections from Cerebrospinal Fluid Exposures

The central nervous system (CNS) distribution and transport mechanisms of the investigational drug candidate CP-615,003 (N-[3-fluoro-4-[2-(propylamino)ethoxy]phenyl]-4,5,6,7-tetrahydro-4-oxo-1H-indole-3-carboxamide) and its active metabolite CP-900,725 have been characterized. Brain distribution of CP-615,003 and CP-900,725 was low in rats and mice (brain-to-serum ratio < 0.2). Cerebrospinal fluid (CSF)-to-serum ratios of CP-615,003 were 6- to 8-fold lower than the plasma unbound fraction in rats and dogs. In vitro, CP-615,003 displayed quinidine-like efflux in MDR1-expressing Madin-Darby canine kidney II cells. The brain-to-serum ratio of CP-615,003 in mdr1a/1b (–/–) mice was ∼7 times that in their wild-type counterparts, confirming that impaired CNS distribution was explained by P-gp efflux transport. In contrast, P-gp efflux did not explain the impaired CNS penetration of CP-900,725. Intracerebral microdialysis was used to characterize rat brain extracellular fluid (ECF) distribution. Interestingly, the ECF-to-serum ratio of the P-gp substrate CP-615,003 was 7-fold below the CSF-to-serum ratio, whereas this disequilibrium was not observed for CP-900,725. In a clinical study, steady-state CSF exposures were measured after administration of 100 mg of CP-615,003 b.i. d. The human CSF-to-plasma ratios of CP-615,003 and CP-900,725 were both ∼10-fold below their ex vivo plasma unbound fractions, confirming impaired human CNS penetration. Preliminary estimates of CNS receptor occupancy from human CSF concentrations were sensitive to assumptions regarding the magnitude of the CSF-ECF gradient for CP-615,003 in humans. In summary, this case provides an example of intersite differences in CNS pharmacokinetics of a P-gp substrate and potential implications for projection of human CNS receptor occupancy of transporter substrates from CSF pharmacokinetic data when direct imaging-based approaches are not feasible.
Inventory Management Optimization as Part of Operational Risk Management

The basic financial purpose of an enterprise is maximization of its value. Inventory management should also contribute to realization of this fundamental aim. The enterprise value maximization strategy is executed with a focus on risk and uncertainty. This article presents the consequences for the recipients firm that can result from operating risk that is related to delivery risk generated by the suppliers. The present article offers a method that uses portfolio management theory to chose the suppliers.
Exploring the link between management talent and perceived performance in multinational corporations (MNCs)

Purpose – To examine the association between talent management (TM) and perceived subsidiary performance. Focus is given to the development of one key talent group – line managers – in subsidiaries of multinational corporations (MNCs). Specifically, the paper examines: whether there is a positive relationship between Management Development (MD) and perceived subsidiary performance; and whether national context mediates any link between MD and perceived subsidiary performance.Design/methodology/approach – A multi‐respondent survey was undertaken generating a sample of 143 UK‐owned MNCs. For each organisation, interviews were completed with the Head of HR at corporate Head Quarters; the HR Manager/Specialist and a line manager in both the domestic and foreign subsidiaries of the sample organisation. A total of 5 respondents per organisation is used in the analysis.Findings – The link between the MD variables and perceived subsidiary performance is consistently positive and robust in all of the models estima.
A two adenine insertion polymorphism in the 3’ untranslated region of factor VII gene is associated with peripheral arterial disease but not with venous thrombosis

Summary Polymorphic variants of genes encoding blood coagulation proteins have been extensively studied as risk factors for venous or arterial thrombosis A variation in the 3' untranslated region (UTR) involved in the post-transcriptional regulation of factor VII (FVII) gene has been recently identified, a two adenine insertion/deletion at nucleotide 11293. In this study, we investigated its effect on the risk of thrombosis in the frame of two case-control studies, including patients suffering from peripheral arterial disease (PAD) or venous thromboembolic (VTE) disease. The 3’UTR FVII gene polymorphism was investigated i) in 181 patients who had symptomatic atherosclerotic disease of the lower limbs, ii) in 178 patients who had had at least one episode of objectively diagnosed deep venous thrombosis and iii) in controls matched for age and sex. Plasma FVII antigen (FVII:Ag) levels were lower in the presence of the 3’UTR 2A insertion (68.4 ± 12.3%, 81.3 ± 14.5% and 89.5 ± 13.7% in 2A/2A, 2A/0 and 0/0 subjects respectively, p<0.0001). No significant relationship was found with VTE disease. In the contrary we observed a lower risk of PAD for the 2A/2A compared to the 0/0 genotype after adjustment for traditional risk factors (hypercholesterolemia, smoking status, diabetes and hypertension), with an OR of 0.24 [95% CI 0.06–0.99]. In conclusion, the 2 adenine insertion in the 3’UTR of FVII gene, related to lower plasma FVII levels, is a genetic variation that may contribute to reduce the risk of PAD.
The Service Industries

The services industry is based on performing work for others as an occupation or business. It includes establishments primarily engaged in providing a wide variety of services to individuals, businesses, government, and other organizations. The establishments included are hotels and other lodging places; establishments providing personal, business, repair, and amusement services; health, legal, engineering, and other professional services; educational institutions; membership organizations, and other miscellaneous services.
The use of social media in destination marketing: An exploratory study

Social media provides customers and businesses of modern times with an unprecedented growth in ways of communication and interaction. Tourism organisations can benefi t from the limitless opportunities off ered by social media and ideally, evolve their relationship with their customers into a networked process of innovation. While there is a growing number of social media studies in the context of tourism, few researches have addressed the application of social media by tourism providers. Th us, this study employed an exploratory research design aimed at establishing a detailed understanding of current use of social media among National Tourism Organizations (NTOs) of the world’s 193 countries. To this end, data mining was used to identify the social media applications and types that are used by NTOs, and it was followed by content analysis, to investigate NTOs’ strategic use of social media. Th e fi ndings of this study suggest that many NTOs are still not aware of potential and opportunities off ered by social media and for those with social media presence, there is a great room for improvement in strategic use of social media. Th is study contributes to the existing body of literature by providing an understanding of use of social media in destination marketing. Th e study also off ers some interesting insights for tourism marketers.
Diagrammatic scale to assess downy mildew severity in melon

The downy mildew, caused by Pseudoperonospora cubensis, is an important melon disease in Northeast Brazil. Considering the lack of standard methods for its assessment, a diagrammatic scale was developed with 2, 4, 8, 16, 32, 64, 82, and 96% of affected leaf area. The scale was then checked for its accuracy, precision, and reproducibility in estimating downy mildew severity. The diagrammatic scale was validated by eight disease raters; using 50 leaves with different severity levels, previously measured using the software Assess®. Two evaluations were performed on the same set of leaves, but in a different sequence order, by the same raters, within a 15-day interval. The accuracy and precision of each rater was determined by simple linear regression between the actual and the estimated severity. The scale provided good levels of accuracy (means of 87.5%) and excellent levels of precision (means of 94%), with absolute errors concentrated around 10%. Raters showed great repeatability (means of 94%) and reproducibility (>90% in 90.3% of cases) of estimates. Therefore, we could conclude that the diagrammatic scale presented here was suitable for evaluating downy mildew severity in melon.
Whom Would You Choose? The Role of Trust in New Venture Partner Choice

What is the role of trust in new venture partner choice? To answer this question, this study uses a human capital framework to investigate the relative importance of the factors of trustworthiness (i.e. ability, benevolence and integrity) in the decision to choose a new venture partner. A second query is, ‘how does familiarity of a potential partner contribute to the choice? This study also explores the moderating influences of propensity to trust, gender and race in new venture partner decision policies. This research uses conjoint analysis and hierarchical linear modeling techniques to capture and decompose more than 3700 new venture partner choice evaluations which are nested in a sample of 116 CPAs. The findings of this study suggest that trust is important in the choice of new venture partner. Specifically, the results show that among this study’s sample, the factors of trustworthiness are more important than familiarity. Also found was that integrity is more important than ability and benevolence in new venture partner choice and that propensity to trust moderates the choice. This research offers several contributions. First, this study delves into the underexplored area of new venture team formation and is one of the first to investigate the role of trust in this context. Using a human capital framework, the conceptualization of this concept is extended to include trustworthiness. Methodologically, this study is one of the first to use conjoint analysis in the study of new venture team formation and in the study of trust. Finally, implications for theory, practice and future research are discussed. WHOM WOULD YOU CHOOSE? THE ROLE OF TRUST IN NEW VENTURE PARTNER CHOICE
Interactions of Porphyromonas gingivalis with epithelial cells

The invasion of gingival epithelial cells by certain pathogenic periodontal bacteria may account for their presence within diseased gingival tissue. To dissect the initial steps of a potential invasion pathway for the periodontal pathogen Porphyromonas gingivalis, laboratory and clinical bacterial isolates were tested for their interactions with a human oral epithelial cell line (KB). Several P. gingivalis strains immobilized on filters could bind oral epithelial cells. Quantitative adherence assays supported these results. The invasion of epithelial cells by P. gingivalis 33277 was measured by assay and confirmed by transmission electron microscopy. These preliminary results demonstrate that certain P. gingivalis strains are capable of internalization by human oral epithelial cells in vitro.
A tutorial on Bayesian bivariate meta‐analysis of mixed binary‐continuous outcomes with missing treatment effects

Bivariate random‐effects meta‐analysis (BVMA) is a method of data synthesis that accounts for treatment effects measured on two outcomes. BVMA gives more precise estimates of the population mean and predicted values than two univariate random‐effects meta‐analyses (UVMAs). BVMA also addresses bias from incomplete reporting of outcomes.
Incidence, Mechanisms, and Severity of Match-Related Collegiate Women’s Soccer Injuries on FieldTurf and Natural Grass Surfaces

Background: Numerous injuries have been attributed to playing on artificial turf. Over the past 2 decades, however, newer generations of synthetic turf have been developed to duplicate the playing characteristics of natural grass. Although synthetic turf has been determined to be safer than natural grass in some studies, few long-term studies have been conducted comparing match-related collegiate soccer injuries between the 2 playing surfaces. Hypothesis: Collegiate female soccer athletes do not experience any difference in the incidence, mechanisms, and severity of match-related injuries on FieldTurf and on natural grass. Study Design: Cohort study: Level of evidence, 2. Methods: Female soccer athletes from 13 universities were evaluated over 5 competitive seasons for injury incidence, injury category, time of injury, injury time loss, player position, injury mechanism and situation, primary type of injury, injury grade and anatomic location, field location at the time of injury, injury severity, head and lower extremity trauma, cleat design, turf age, and environmental factors. In sum, 797 collegiate games were evaluated for match-related soccer injuries sustained on FieldTurf or natural grass during 5 seasons. Results: Overall, 355 team games (44.5%) were played on FieldTurf versus 442 team games (55.5%) on natural grass. A total of 693 injuries were documented, with 272 (39.2%) occurring during play on FieldTurf and 421 (60.8%) on natural grass. Multivariate analysis per 10 team games indicated a significant playing surface effect: F2,690 = 6.435, P = . 002, n – β = . 904. A significantly lower total injury incidence rate (IIR) of 7.7 (95% confidence interval [CI], 7.2-8.1) versus 9.5 (95% CI, 9.3-9.7) (P = .0001) and lower rate of substantial injuries, 0.7 (95% CI, 0.5-1.0) versus 1.5 (95% CI, 1.2-1.9) (P = .001), were documented on FieldTurf versus natural grass, respectively. Analyses also indicated significantly less trauma on FieldTurf when comparing injury time loss, player position, injury grade, injuries under various field conditions and temperatures, cleat design, and turf age. Conclusion: Although similarities existed between FieldTurf and natural grass during competitive match play, FieldTurf is a practical alternative when comparing injuries in collegiate women’s soccer. It must be reiterated that the findings of this study may be generalizable to only collegiate competition and this specific artificial surface.
Generic Change of the Partial Multiplicities of Regular Matrix Pencils under Low-Rank Perturbations

We describe the generic change of the partial multiplicities at a given eigenvalue $\lambda_0$ of a regular matrix pencil $A_0+\lambda A_1$ under perturbations with low normal rank. More precisely, if the pencil $A_0+\lambda A_1$ has exactly $g$ nonzero partial multiplicities at $\lambda_0$, then for most perturbations $B_0+\lambda B_1$ with normal rank $r<g$ the perturbed pencil $A_0+B_0+\lambda(A_1+B_1)$ has exactly $g-r$ nonzero partial multiplicities at $\lambda_0$, which coincide with those obtained after removing the largest $r$ partial multiplicities of the original pencil $A_0+\lambda A_1$ at $\lambda_0$. Though partial results on this problem had been previously obtained in the literature, its complete solution remained open.
Time–frequency analysis of phonocardiogram signals using wavelet transform: a comparative study

Analysis of phonocardiogram (PCG) signals provides a non-invasive means to determine the abnormalities caused by cardiovascular system pathology. In general, time–frequency representation (TFR) methods are used to study the PCG signal because it is one of the non-stationary bio-signals. The continuous wavelet transform (CWT) is especially suitable for the analysis of non-stationary signals and to obtain the TFR, due to its high resolution, both in time and in frequency and has recently become a favourite tool. It decomposes a signal in terms of elementary contributions called wavelets, which are shifted and dilated copies of a fixed mother wavelet function, and yields a joint TFR. Although the basic characteristics of the wavelets are similar, each type of the wavelets produces a different TFR. In this study, eight real types of the most known wavelets are examined on typical PCG signals indicating heart abnormalities in order to determine the best wavelet to obtain a reliable TFR. For this purpose, the wavelet energy and frequency spectrum estimations based on the CWT and the spectra of the chosen wavelets were compared with the energy distribution and the autoregressive frequency spectra in order to determine the most suitable wavelet. The results show that Morlet wavelet is the most reliable wavelet for the time–frequency analysis of PCG signals.
Brand Loyalty Intention among Members of a Virtual Brand Community: The Dual Role of Commitment

As the use of social media continues to grow, it is important to understand the effect of consumer participation in communities organized around brands on the relationship between the former and the brands concerned. This research examines, through a quantitative study of 1,605 members of a virtual community dedicated to the Nikon brand, the effect of intensity of participation on brand loyalty intention as well as the mediating effect of community commitment within this relationship. Moreover, the bidirectional relationship between community commitment and brand commitment are studied and confirmed. Finally, the moderating role of membership length is emphasized.
Genome-Wide Evolution and Comparative Analysis of Superoxide Dismutase Gene Family in Cucurbitaceae and Expression Analysis of Lagenaria siceraria Under Multiple Abiotic Stresses

Superoxide dismutase (SOD) is an important enzyme that serves as the first line of defense in the plant antioxidant system and removes reactive oxygen species (ROS) under adverse conditions. The SOD protein family is widely distributed in the plant kingdom and plays a significant role in plant growth and development. However, the comprehensive analysis of the SOD gene family has not been conducted in Cucurbitaceae. Subsequently, 43 SOD genes were identified from Cucurbitaceae species [Citrullus lanatus (watermelon), Cucurbita pepo (zucchini), Cucumis sativus (cucumber), Lagenaria siceraria (bottle gourd), Cucumis melo (melon)]. According to evolutionary analysis, SOD genes were divided into eight subfamilies (I, II, III, IV, V, VI, VII, VIII). The gene structure analysis exhibited that the SOD gene family had comparatively preserved exon/intron assembly and motif as well. Phylogenetic and structural analysis revealed the functional divergence of Cucurbitaceae SOD gene family. Furthermore, microRNAs 6 miRNAs were predicted targeting 3 LsiSOD genes. Gene ontology annotation outcomes confirm the role of LsiSODs under different stress stimuli, cellular oxidant detoxification processes, metal ion binding activities, SOD activity, and different cellular components. Promoter regions of the SOD family revealed that most cis-elements were involved in plant development, stress response, and plant hormones. Evaluation of the gene expression showed that most SOD genes were expressed in different tissues (root, flower, fruit, stem, and leaf). Finally, the expression profiles of eight LsiSOD genes analyzed by qRT-PCR suggested that these genetic reserves responded to drought, saline, heat, and cold stress. These findings laid the foundation for further study of the role of the SOD gene family in Cucurbitaceae. Also, they provided the potential for its use in the genetic improvement of Cucurbitaceae.
Gender is not a factor in serum human immunodeficiency virus type 1 RNA levels in patients with viremia

We investigated gender as a factor in viral load measurements for human immunodeficiency virus-infected patients. Forty antiretroviral-therapy-naive, age- and CD4-matched women and men were tested for serum RNA and p24 antigen levels prior to antiretroviral therapy and at approximately 12 weeks after therapy. No gender differences were observed for these two markers of viral load.
The Operating and Shareprice Performance of Initial Public Offerings: The UK Experience

We study the post-issue operating performance of UK Initial Public Offerings. Using several measures, we find that the performance of firms going public on the Official List deteriorates significantly after the issue. On the contrary, IPO-firms on the Alternative Investment Market (AIM) use the IPO as springboard for growth without sacrificing their profitability. The AIM is, indeed, the first market where operating performance is not found to be declining after the IPO. The listing on the AIM does not affect significantly the leverage of the firms, but gives the opportunity to raise fresh funds, both at the time of the initial offering and through further (debt or equity) capital raisings. Conversely, the permanent decrease in leverage after the IPO on the Official List characterizes the flotation on this market as a mean to rebalance the firms' capital structure.