Miracle-dz/UniFAR-FTUs huggingface dataset:
Computational modeling of Weibo user influence based on information interactive network

Purpose With the development and application of mobile internet access, social media represented by Weibo, WeChat, etc. has become the main channel for information release and sharing. High-impact users in social networks are key factors stimulating the large-scale propagation of information within social networks. User influence is usually related to the user’s attention rate, activity level, and message content. The paper aims to discuss these issues. Design/methodology/approach In this paper, the authors focused on Sina Weibo users, centered on users’ behavior and interactive information, and formulated a weighted interactive information network model, then present a novel computational model for Weibo user influence, which combined multiple indexes such as the user’s attention rate, activity level, and message content influence, etc., the model incorporated the time dimension, through the calculation of users’ attribute influence and interactive influence, to comprehensively measure the user influence of Sina Weibo users. Findings Compared with other models, the model reflected the dynamics and timeliness of the user influence in a more accurate way. Extensive experiments are conducted on the real-world data set, and the results validate the performance of the approach, and demonstrate the effectiveness of the dynamics and timeliness. Due to the similarity in platform architecture and user behavior between Sina Weibo and Twitter, the calculation model is also applicable to Twitter. Originality/value This paper presents a novel computational model for Weibo user influence, which combined multiple indexes such as the user’s attention rate, activity level, and message content influence, etc.
Increased death risk and altered cancer incidence pattern in patients with isolated or combined autoimmune primary adrenocortical insufficiency

Objectives Primary adrenocortical insufficiency is mostly caused by an autoimmune destruction of the adrenal cortex. The disease may appear isolated or as a part of an autoimmune polyendocrine syndrome (APS). APS1 is a rare hereditary disorder with a broad spectrum of clinical manifestations. In APS2, primary adrenocortical insufficiency is often combined with autoimmune thyroid disease and/or type 1 diabetes. We analysed mortality and cancer incidence in primary adrenocortical insufficiency patients during 40 years. Data were compared with the general Swedish population.
What makes Women Sick: Gender and the Political Economy of Health

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Intestinal digesta viscosity decreases during coccidial infection in broilers

1. The effect of intestinal digesta viscosity on bird performance in chickens with coccidiosis was compared to those without coccidiosis. 2. Six hundred chicks were divided into five groups: one control group was fed a basal maize/soyabean-based diet and the other groups were fed the basal diet supplemented with 2, 4, 6 or 8 g carboxymethyl cellulose (CMC) per kg of feed. At 14 d of age half the birds were individually inoculated with sporulated oocysts of Eimeria acervulina and Eimeria praecox. 3. Intestinal digesta viscosity increased with increasing inclusion of CMC. This effect was considerably less pronounced in inoculated than in non-inoculated birds. 4. There was a significant negative effect on live weight gain and feed conversion ratio (FCR) with increasing CMC inclusion in non-inoculated birds, but in inoculated birds there was no clear relation between CMC inclusion and performance. Neither intestinal lesion scores, nor numbers of Clostridium perfringens in the caeca, were significantly affected by CMC inclusion. 5. Across all diets inoculation impaired growth rate by 9% and FCR by 8%, but did not affect the amount of C. perfringens in the caeca.
Prediction of Clearance of Cervical Intraepithelial Neoplasia by Conization

In this review of 531 cervical conizations and 268 hysterectomies, the presence or absence of cervical intraepithelial neoplasia (CIN) at the margins of the cervical conization failed to predict the presence or absence of residual neoplasia in the excised uterus (P>.10). Older patients and patients with CIN III Papanicolaou smears had a significantly greater chance of having noncleared cone margins (P<.0005); no other criteria predictive of nonclearance emerged in this study. Two of 26 patients with CIN III at the cone apex or in the apical biopsies had residual stage IA neoplasia in the excised uterus. Conversely, when the cone predicted clearance, CIN III was the worst residual diagnosis
Adaptive model-predictive controller for magnetic resonance guided focused ultrasound therapy

Abstract Purpose: Minimising treatment time and protecting healthy tissues are conflicting goals that play major roles in making magnetic resonance image-guided focused ultrasound (MRgFUS) therapies clinically practical. We have developed and tested in vivo an adaptive model-predictive controller (AMPC) that reduces treatment time, ensures safety and efficacy, and provides flexibility in treatment set-up. Materials and methods: The controller realises time savings by modelling the heated treatment cell’s future temperatures and thermal dose accumulation in order to anticipate the optimal time to switch to the next cell. Selected tissues are safeguarded by a configurable temperature constraint. Simulations quantified the time savings realised by each controller feature as well as the trade-offs between competing safety and treatment time parameters. In vivo experiments in rabbit thighs established the controller’s effectiveness and reliability. Results: In all in vivo experiments the target thermal dose of at least 240 CEM43 was delivered everywhere in the treatment volume. The controller’s temperature safety limit reliably activated and constrained all protected tissues to <9 CEM43. Simulations demonstrated the path independence of the controller, and that a path which successively proceeds to the hottest untreated neighbouring cell leads to significant time savings, e.g. when compared to a concentric spiral path. Use of the AMPC produced a compounding time-saving effect; reducing the treatment cells’ heating times concurrently reduced heating of normal tissues, which eliminated cooling periods. Conclusions: Adaptive model-predictive control can automatically deliver safe, effective MRgFUS treatments while significantly reducing treatment times.
rme1 Mutation of Saccharomyces cerevisiae: map position and bypass of mating type locus control of sporulation

Sporulation in Saccharomyces cerevisiae normally occurs only in MATa/MAT alpha diploids. We show that mutations in RME1 bypassed the requirements for both a and alpha mating type information in sporulation and therefore allowed MATa/MATa and MAT alpha/MAT alpha diploids to sporulate. RME1 was located on chromosome VII, between LEU1 and ADE6.
Intraperitoneal N-acetylcysteine for acute iron intoxication in rats

Free radical formation and release of oxidant agents have been suggested as possible mechanisms for tissue damage in acute iron intoxication. N-acetylcysteine (NAC), a glutathione substitute and an antioxidant, is widely used as an antidote for various intoxications. Our aim was to determine whether intraperitoneal (i.p.) NAC would reduce the mortality of rats after acute, toxic oral doses of iron. Male Wistar rats were studied in three phases. In the first phase, animals were assigned to groups 1 (distilled water by gavage) and 2 (i.p. NAC) and observed for survival. In the second phase, rats were assigned to groups 3 (400 mg/kg elemental iron orally) and 4 (400 mg/kg elemental iron, followed by 150 mg/kg i.p. NAC). Survival was observed. Because most rats in Group 3 died within 90 minutes after iron administration, a third phase was conducted in order to allow for comparison of iron and transaminase serum levels after the administration of iron and NAC (group 5: n = 10). Mortality was significantly lower in rats treated with iron and NAC, compared to those treated with iron (P = 0.016). Median serum iron level was significantly lower among rats treated with iron and NAC, compared with rats treated with iron alone (P = 0.002). In a rat model of acute iron intoxication, i.p. administration of NAC may decrease serum iron levels and mortality.
Expression of Herpes Simplex Virus 1-Encoded MicroRNAs in Human Trigeminal Ganglia and Their Relation to Local T-Cell Infiltrates

ABSTRACT Herpes simplex type 1 (HSV-1) is a neurotropic virus which establishes lifelong latency in human trigeminal ganglia (TG). Currently, two nonexclusive control mechanisms of HSV-1 latency are discussed: antiviral CD8+ T cells and viral microRNAs (miRNAs) encoded by the latency associated transcript (LAT). We investigate here to what extent these mechanisms may contribute to the maintenance of HSV-1 latency. We show that only a small proportion of LAT+ neurons is surrounded by T cells in human TG. This indicates that viral latency in human TG might be controlled by other mechanisms such as viral miRNAs. Therefore, we assessed TG sections for the presence of HSV-1 miRNA, DNA, and mRNA by combining LAT in situ hybridization, T-cell immunohistochemistry, and single cell analysis of laser-microdissected sensory neurons. Quantitative reverse transcription-PCR (RT-PCR) revealed that LAT+ neurons with or without surrounding T cells were always positive for HSV-1 miRNAs and DNA. Furthermore, ICP0 mRNA could rarely be detected only in LAT+ neurons, as analyzed by single-cell RT-PCR. In contrast, in LAT− neurons that were surrounded by T cells, neither miRNAs nor the DNA of HSV-1, HSV-2, or varicella-zoster virus could be detected. These data indicate that the majority of LAT+ neurons is not directly controlled by T cells. However, miRNA expression in every latently infected neuron would provide an additional checkpoint before viral replication is initiated.
The long path towards implementation of clinical proteomics: Exemplified based on CKD273

Clinical proteomics aims at the development and the implementation of novel biomarkers that demonstrate a clear clinical benefit in the management of diseases. However, though the attention in the field is increasing and multiple articles on biomarker research are published, clinical implementation of these biomarkers is scarce. In this paper, we aim towards identifying the hurdles on the path towards implementation, and present one successful approach, based on capillary electrophoresis coupled with mass spectrometry. A panel of biomarkers identified and assessed using this approach, termed CKD273, has recently received a Letter‐of‐Support from the US‐Food and Drug Administration (FDA), and is now implemented in the (early) management of chronic kidney disease. Based on this experience in the process towards implementation of CKD273, issues associated with implementation and suggestions how to meet these challenges are given.
Identifying individuals with multiple sclerosis in an electronic medical record

Background: The increasing use of electronic medical records (EMRs) presents an opportunity to efficiently evaluate and improve quality of care for individuals with MS. Objectives: We aimed to establish an algorithm to identify individuals with MS within EMRs. Methods: We used a sample of 73,003 adult patients from 83 primary care physicians in Ontario using the Electronic Medical Record Administrative data Linked Database (EMRALD). A reference standard of 247 individuals with MS was identified through chart abstraction. The accuracy of identifying individuals with MS in an EMR was assessed using information in the cumulative patient profile (CPP), prescriptions and physician billing codes. Results: An algorithm identifying MS in the CPP performed well with 91.5% sensitivity, 100% specificity, 98.7% PPV and 100% NPV. The addition of prescriptions for MS-specific medications and physician billing code 340 used four times within any 12-month timeframe slightly improved the sensitivity to 92.3% with a PPV of 97.9%. Conclusions: Data within an EMR can be used to accurately identify patients with MS. This study has positive implications for clinicians, researchers and policy makers as it provides the potential to identify cohorts of MS patients in the primary care setting to examine quality of care.
The effects of l-arginine on crypt cell hyperproliferation in colorectal cancer.

BACKGROUND Colonic crypt cell hyperproliferation characterizes malignant and premalignant conditions of the colon and may be modified by dietary manipulation. This study compared the effect of dietary arginine supplementation on colonic crypt cell proliferation during the initiation and promotion stages of colorectal carcinogenesis. MATERIALS AND METHODS One hundred and twenty male Wistar rats were divided into 5 groups of 24 animals each. Groups D, DA, FA, and LA received subcutaneous injections of 1, 2-dimethylhydrazine for 20 weeks. Group D received no arginine supplement. l-arginine was given as a 1% solution instead of drinking water to Group DA for 22 weeks, to Group FA for the first 10 weeks, and to Group LA for the last 12 weeks. EDTA animals were given subcutaneous injections of EDTA for 20 weeks. Colonic crypt cell proliferation was assessed in 6 animals from each of the five groups and in 6 normal rats not given DMH or EDTA. RESULTS The BrdUrd-labeling index and proliferative zone were significantly decreased in all arginine groups (DA, FA, LA). The greatest reduction was evident in Group FA in which tumor incidence and tumor size were also significantly lowered. CONCLUSIONS When given during the initiation phase of carcinogenesis l-arginine significantly reduced colorectal tumor production and crypt cell hyperproliferation.
RSK VIA LOCAL TRANSFORMATIONS

RSK is normally defined in terms of a somewhat complicated procedure called row-insertion. This definition unfortunately masks the remarkable symmetry property that if A RSK 7−−−→ (P,Q) then At RSK 7−−−→ (Q,P ). Here we present an alternate description of RSK via local transformations that makes the symmetry obvious. Our approach is thus similar in spirit to the growth diagrams of Fomin [6]. In order to motivate this description, we first examine the Gelfand-Tsetlin patterns associated to the Young tableaux that result from RSK, and show how RSK can be thought of as a map between matrices.
Oral Progesterone Treatment in a Young Woman With Müllerian Adenosarcoma Whose Ovary Was Preserved: A Case Report

Müllerian adenosarcoma is a rare biphasic tumor in young women. These tumors can recur even after complete resection. We present a patient treated with oral progesterone after hysterectomy with ovary conservation. A 35-year-old woman had a diagnosis of adenosarcoma on hysteroscopic resection, which was estrogen and progesterone receptor positive. She underwent total hysterectomy with ovary conservation and has received oral medroxyprogesterone acetate treatment. At 15 months after surgery, there has been no disease recurrence. Oral medroxyprogesterone acetate therapy can be used effectively in young women with müllerian adenosarcoma whose ovaries are preserved.
Dimensioning X2 backhaul link in LTE networks

A central objective in designing Long Term Evolution networks (LTE) is to provide a better quality of experience for the end user. One of the implemented enhancements is a direct connection between neighbouring base stations through X2 interface. This interface enables mobility management and the transfer of the user's data in case of a handover. The aim of this paper is to study the impact of user mobility on capacity planning and to provide an analytical model to dimension the X2 bandwidth under certain performance objectives.
Discovery of the hepatitis C virus

After nearly 6 years of intensive investigations between 1982 and 1988 in my laboratory at Chiron corporation, in which numerous molecular biological methods were used to investigate the viral aetiology of parenterally transmitted non‐A, non‐B viral hepatitis (NANBH), a single cDNA clone (5‐1‐1) was isolated that was shown to be derived from a new flavi‐like virus, termed the hepatitis C virus (HCV). After screening hundreds of millions of bacterial cDNA clones derived from different liver and plasma samples obtained from experimentally infected chimpanzees, a single HCV clone was eventually isolated using a novel, blind immunoscreening method in which antibodies derived from a clinically diagnosed NANBH patient were used to identify a cDNA clone encoding an immunodominant epitope within HCV nonstructural protein 4. Its viral origin was demonstrated by its specific hybridization to a large single‐stranded RNA molecule of ∼10 000 nucleotides found only in NANBH‐infected samples that shared distant sequence identity with flaviviruses. Further, HCV clone 5‐1‐1 was shown to be extrachromosomal and to encode an antigen eliciting antibody seroconversion only in NANBH‐infected chimpanzees and humans. Subsequent work demonstrated that HCV was the principal cause of parenterally transmitted NANBH around the world, with an estimated 170 million global carriers and that blood screening tests detecting circulating HCV antibodies and viral RNA could effectively eradicate the transmission of transfusion‐associated NANBH. Key viral‐encoded enzymes essential to its life cycle are now the targets of vigorous, ongoing drug development activities, and the feasibility of successful vaccination strategies has been demonstrated using the valuable chimpanzee model, without which any progress on HCV would not have been possible. My colleagues and coworkers who made essential contributions to the discovery of HCV were George Kuo, who had his own laboratory at Chiron and who provided intellectual and practical input, Dan Bradley of the Centers for Disease Control and Prevention, who provided a large supply of well‐characterized chimpanzee samples and knowledge of the NANBH field, and Qui‐Lim Choo, in my own laboratory, who provided many years of outstandingly dedicated and precise molecular biology expertise.
Displacment amplification and latching mechanism using V-shape actuators in design of electro-thermal MEMS switches

This paper reports two unique mechanisms using “V-shape” electro-thermal actuators to realize large displacement and reliable contact in MEMS switches. The first mechanism is a novel displacement amplification system that enables a large in-plane traveling distance for closing the gap between switch contacts. The structure features a movable end and pivot joints connecting to the amplification beam that can result in smaller actuating force distinguishing this mechanism from others. The second mechanism involves a unique latching system to provide a large lateral force for reliable contact. In both mechanisms, out-of-plane displacements are minimized due to the structural symmetry of the “V-shape” actuators. The devices are fabricated using PolyMUMPS process. At 1 V driving voltage for 2 pairs of 3-arm V-shape actuators, the displacement amplification system provides a gain of ∼6.5 while consuming 2×3.8 mW power. Each 4-arm V-shape latching actuator generates ∼2.7 µm displacement and ∼240 µN contact force with a power consumption of ∼2.2 mW.
Reliability and Validity of the Turkish Version of the Moral Development Scale for Professionals

Background: Moral development is an important element for professionals to achieve their objectives and targets. A scale that measures the moral development levels of professionals has not been encountered in Turkey. Aim: The present study was intended to adapt to Turkish the Moral Development Scale for Professionals and to access its reliability and validity. Methodology: The scale was adapted to Turkish and its linguistic and content validity was assessed in this study. Moreover, the reliability of the scale was accessed by Test-Retest; the internal consistency was checked by Cronbach α, while exploratory factor analysis and confirmatory factor analysis were also conducted. Results: The factor analysis applied showed that the eigenvalue of the two factors were 4.112 and 1.140 respectively. The variance percentages of the factors were 34.267% and 9.496%, respectively. The total variance explained by the factors was found to be 43.764%. Conclusions: The translated in Turkish Moral Development Scale’s properties found to be very satisfactory indicating that the scale is a reliable and valid instrument for assessing moral development in professionals.
Loop-mediated isothermal ampliﬁcation (LAMP): recent progress in research and development

Loop-mediated isothermal ampliﬁcation (LAMP) is an established technology that continues to attract the attention of researchers in many ﬁelds. Research and development efforts on LAMP technology in recent years have focused on two major areas; ﬁrst, the study of its clinical application as an approved in vitro diagnostics tool in Japan and certain other countries; and second, research aimed at further simplifying the LAMP test process. This review pro-videsanoverviewofthestatusofLAMPonthesetwotopicsby summarizing research work conducted, in the main, after our previous review article.
Flagellate Erythema in a Case of Paraneoplastic Dermatomyositis.

CASE A 68-year-old woman presented a history of fatigue and proximal muscle weakness for 6 months. Physical examination revealed heliotrope rash, Gottron’s papules, poikilodermatous plaques on lateral thighs (the “holster” sign), and striking erythematous linear plaques on her back consistent with flagellate erythema (Fig. 1). The laboratory tests revealed elevated creatine kinase and lactate dehydrogenase and positive HEP-2 antinuclear antibodies at 1/1280 dilution in a mottled pattern. There was proximal myopathy in electromyography. Skin biopsy showed moderate vacuolar degeneration of basal keratinocytes along with perivascular inflammatory infiltration and a negative direct immunofluorescence analysis. Muscle biopsy showed noninflammatory perifascicular atrophy. Both histopathological studies were compatible with dermatomyositis. A differentiated tubular adenocarcinoma was found after occult neoplasia study. Dermatomyositis is an inflammatory disease that typically presents with muscle and skin involvement. Among the skin lesions that associate with this condition are the heliotrope rash, the Gottron’s papules, the “holster sign,” and—less frequently— flagellate erythema. The latter is described as edematous and