Miracle-dz/UniFAR-FTUs huggingface dataset:
Autologous bone marrow mononuclear cells modulate joint homeostasis in an equine in vivo model of synovitis

Osteoarthritis (OA) is characterized by macrophage‐driven synovitis. Macrophages promote synovial health but become inflammatory when their regulatory functions are overwhelmed. Bone marrow mononuclear cells (BMNCs) are a rich source of macrophage progenitors used for treating chronic inflammation and produce essential molecules for cartilage metabolism. This study investigated the response to autologous BMNC injection in normal and inflamed joints. Synovitis was induced in both radiocarpal joints of 6 horses. After 8 h, 1 inflamed radiocarpal and 1 normal tarsocrural joint received BMNC injection. Contralateral joints were injected with saline. Synovial fluid was collected at 24, 96, and 144 h for cytology, cytokine quantification, and flow cytometry. At 144 h, horses were euthanatized, joints were evaluated, and synovium was harvested for histology and immunohistochemistry. Four days after BMNC treatment, inflamed joints had 24% higher macrophage counts with 10% more IL‐10+ cells than saline‐treated controls. BMNC‐treated joints showed gross and analytical improvements in synovial fluid and synovial membrane, with increasing regulatory macrophages and synovial fluid IL‐10 concentrations compared with saline‐treated controls. BMNC‐treated joints were comparable to healthy joints histologically, which remained abnormal in saline‐treated controls. Autologous BMNCs are readily available, regulate synovitis through macrophage‐associated effects, and can benefit thousands of patients with OA. —Menarim, B. C. , Gillis, K.H. , Oliver, A. , Mason, C. , Ngo, Y. , Werre, S.R. , Barrett, S.H. , Luo, X. , Byron, C.R. , Dahlgren, L. A. Autologous bone marrow mononuclear cells modulate joint homeostasis in an equine in vivo model of synovitis. FASEB J. 33, 14337‐14353 (2019). www.fasebj. org
Effects of a greater incentive to attack the head & face region on incidence of head kicks and concussions among male youth taekwondo competitors.

BACKGROUND In an attempt to improve the technical quality of sparring taekwondo, the World Taekwondo Federation has amended the competition rule for a head kick (HK), increasing the number of points awarded for this type of attack. The purpose of the current study was to: i) evaluate the incidence of HKs and concussions and ii) identify potential risk factors of concussions in sparring taekwondo. METHODS A post-match, interview-based prospective cohort study was conducted with 145 sparring taekwondo athletes (12-16 years of age) who: i) competed at a 2018 sparring- Taekwondo tournament and ii) received a valid HK during competition. Incidence rates of HKs and concussions were estimated; possible risk factors or prognosticators of concussions were also analyzed using the chi-square test and binary logistic analysis. RESULTS Incidence rates of HKs and concussions were 133.5 (95% CI: 113.3-153.8) and 41.4 (95% CI: 29.6-53.3) per 1000 athlete-exposures, respectively. The binary logistic model revealed that athletes with no prior concussion history were less likely to experience a concussion (OR, 0.27; 95% CI, 0.1-0.7). CONCLUSIONS Although the incidence rates of HKs and concussions are considerably high, they are not increased compared with the results of pre-2009 studies. Therefore, the new competition rule relating to HKs did not appear to increase the incidence rates of HKs or concussions in our research participants. To prevent adverse effects related to repetitive HKs and concussions, continuous research is needed.
Age-related Hearing Loss Is Strongly Associated With Cognitive Decline Regardless of the APOE4 Polymorphism.

OBJECTIVE To examine the association between hearing impairment and cognitive decline and to identify possible risk factors for presbycusis. STUDY DESIGN Cross-sectional survey in prospective cohort study. SETTING University hospital. PATIENTS A total of 322 participants aged >60 years, for whom all the below data were available, were enrolled in the study. There were 168 females and 154 males with a median age of 71 years (range: 60-89 yrs). INTERVENTIONS PROST (Project in Sado for Total Health), a medical database in Sado island Japan, was analyzed. MAIN OUTCOME MEASURES Data on pure-tone audiometry, mini-mental state examination (MMSE), polymorphism of apolipoprotein E4 (ApoE4), diabetes mellitus, hypertension, smoking, and alcohol consumption were extracted. Hearing impairment was defined as an average frequency between 0.25 and 8 kHz that exceeded 30 dB. Multivariate analysis was used to identify which of the above factors could predict the hearing impairment. Hearing threshold of each Hz was compared between the ApoE4 (+/+), (+/-), and (-/-) groups. RESULTS Among various factors, only low MMSE scores (<24) showed significant association with hearing impairment. There were no differences in the hearing threshold of all frequencies between ApoE status groups. CONCLUSIONS Hearing impairment was associated with low MMSE sores, regardless of the ApoE4 status. If ApoE4 status would be a common upstream predictor for both the hearing and cognitive impairment, hearing threshold would be related to ApoE4 status. However, these results may suggest that hearing impairment may be causally related to the cognitive dysfunction, perhaps via the cognitive load mechanisms.
Multicenter clinical trial on sentinel lymph node biopsy using superparamagnetic iron oxide nanoparticles and a novel handheld magnetic probe

Sentinel lymph node biopsy is a standard staging procedure for early axillary lymph node‐negative breast cancer. As an alternative to the currently used radioactive tracers for sentinel lymph node (SLN) detection during the surgical procedure, a number of studies have shown promising results using superparamagnetic iron oxide (SPIO) nanoparticles. Here, we developed a new handheld, cordless, and lightweight magnetic probe for SPIO detection.
Therapeutic Exercise: Foundations and Techniques

Part I: General Concepts 1. Therapeutic Exercise: Foundational Concepts 2. Prevention and Wellness Part II: Applied Science of Exercise and Techniques 3. Range of Motion for Impaired Movement 4. Resistance Exercise for Impaired Muscle Performance 5. Aerobic Exercise for Impaired Cardiopulmonary Capacity 6. Stretching for Impaired Connective Tissue and Muscle Mobility 7. Peripheral Joint Mobilization for Impaired Joint Mobility 8. Aquatic Exercise 9. Exercises for Impaired Balance Part III: Principles of Intervention for Soft Tissue, Joint and Nerve Pathologies 10. Soft Tissue Injury, Repair, and Management 11. Arthritis, Fibromyalgia, Myofascial Pain Syndrome, Osteoporosis, and Fracture Management 12. Surgery: Pre and Post-operative Management 13. Nerve injury, Nerve Tension, and Sympathetically Maintained Pain Part IV: Exercise Interventions for Impairments by Body Region 14. Shoulder 15. Elbow 16. Wrist & Hand 17. Hip 18. Knee 19. Ankle & Foot 20. The Spine: Structure, Function, and Postural Relationships 21: The Spine: Impairments, Diagnoses, and Management Guidelines 22. The Spine: Exercise Interventions for the Neck and Trunk Part V: Special Areas of Therapeutic Exercise 23. Principles of Exercise for the Obstetric Patient 24. Management of Vascular Disorders of the Extremities 25. Management of Pulmonary Conditions Appendix.
Tofacitinib in Pediatric Psoriasis: An Open-Label Trial to Study Its Safety and Efficacy in Children

Introduction: Psoriasis is a chronic, multifactorial, inflammatory disorder, with an estimated prevalence of 0.71% in children. The commonly used therapeutic agents target the underlying inflammation. Tofacitinib has demonstrated efficacy in adult psoriasis. Aim: To study the efficacy, safety, and tolerability of tofacitinib in pediatric patients with moderate to severe chronic plaque psoriasis. Methods: The study included children aged between 8 and 17 years, with moderate to severe psoriasis, given tofacitinib 5 mg orally twice daily for at least 36 weeks. The clinical response was estimated using the Psoriasis Area and Severity Index (PASI) score, Physician’s Global Assessment (PGA), and the Children’s Dermatology Life Quality Index (CDLQI). The incidence and severity of adverse events (AEs) were meticulously recorded in each case. Results: A total of 47 patients, with a median age of 12.3 years, completed the study. At week 12, 55.32% achieved PASI 75, and 70.21% at week 36. PGA of clear or almost clear responses at week 12 were 59.57 and 65.96%, respectfully, at week 36. Relatively few and mostly minor adverse effects were noted. No severe AEs were reported. Conclusion: The treatment with tofacitinib was safe and well tolerated, and led to significant improvement of their disease and quality of life as reflected in CDLQI scores. However, the results need to be validated in larger multicenter trials.
A tool to identify patients with embolic stroke of undetermined source at high recurrence risk.

OBJECTIVE A tool to stratify the risk of stroke recurrence in patients with embolic stroke of undetermined source (ESUS) could be useful in research and clinical practice. We aimed to determine whether a score can be developed and externally validated for the identification of patients with ESUS at high risk for stroke recurrence. METHODS We pooled the data of all consecutive patients with ESUS from 11 prospective stroke registries. We performed multivariable Cox regression analysis to identify predictors of stroke recurrence. Based on the coefficient of each covariate of the fitted multivariable model, we generated an integer-based point scoring system. We validated the score externally assessing its discrimination and calibration. RESULTS In 3 registries (884 patients) that were used as the derivation cohort, age, leukoaraiosis, and multiterritorial infarct were identified as independent predictors of stroke recurrence and were included in the final score, which assigns 1 point per every decade after 35 years of age, 2 points for leukoaraiosis, and 3 points for multiterritorial infarcts (acute or old nonlacunar). The rate of stroke recurrence was 2.1 per 100 patient-years (95% confidence interval [CI] 1.44-3.06) in patients with a score of 0-4 (low risk), 3.74 (95% CI 2.77-5.04) in patients with a score of 5-6 (intermediate risk), and 8.23 (95% CI 5.99-11.3) in patients with a score of 7-12 (high risk). Compared to low-risk patients, the risk of stroke recurrence was significantly higher in intermediate-risk (hazard ratio [HR] 1.78, 95% CI 1.1-2.88) and high-risk patients (HR 4.67, 95% CI 2.83-7.7). The score was well-calibrated in both derivation and external validation cohorts (8 registries, 820 patients) (Hosmer-Lemeshow test χ2: 12.1 [p = 0.357] and χ2: 21.7 [p = 0.753], respectively). The area under the curve of the score was 0.63 (95% CI 0.58-0.68) and 0.60 (95% CI 0.54-0.66), respectively. CONCLUSIONS The proposed score can assist in the identification of patients with ESUS at high risk for stroke recurrence.
Influence of waves and currents on the growth rate of the kelp Laminaria digitata (Phaeophyceae)

The kelp Laminaria digitata growing in the low intertidal region along energetic coastlines are exposed to a range of hydrodynamic environments. Macroalgae in the intertidal zone can experience both waves and currents independently, but it is unknown how they influence growth rate. Relative growth rate of the meristematic region and the entire blade of L. digitata were measured to assess the influence of wave and current motion from three hydrodynamic environments: low current and low wave (LCLW), high current and low wave (HCLW), and high wave and low current (HWLC). Alongside hydrodynamic data, seawater nutrient concentrations and temperature were also collected and analyzed. Results suggest that differences in L. digitata relative growth rates were not attributed to the seawater nutrient concentrations or temperature, but attributed to the hydrodynamic environments. At the high current condition, kelp growth rate of the meristematic region was enhanced by 45% compared to the high wave condition. When including the entire blade growth rate, an average increase of 25% was observed between the high current and high wave condition. Potentially, the division in growth rate observed between the wave and current motion is related to the frequency and magnitude at which the hydrodynamic forces act. These findings highlight the complexity of the hydrodynamic environment and that forces associated with waves and currents may have a significant role on the productivity of kelp.
Long-term tricuspid valve prosthesis-related complica ons in congenital heart disease

p Background In pa ents with acquired valvar disease, morbidity and mortality rates a er tricuspid valve replacement are high. However, in adult pa ents with congenital heart disease, data concerning outcome a er tricuspid valve replacement are scarce but suggest even poorer results in pa ents with Ebstein anomaly. To inves gate the applicability of these results to a broader array of congenital heart disease pa ents, we report the long-term follow-up of prosthesis-related complica ons (including re-replacement) of pa ents with a tricuspid valve prosthesis and congenital heart disease. Methods From the Dutch Congenital Corvi a (CONCOR) registry we iden fied 20 pa ents with a biological or mechanical tricuspid valve prosthesis implanted between 1977 and 2012 (total of 31 prostheses). We analysed the tricuspid valve-related complica ons and mortality. Results Ten pa ents with a median age of 16.2 years at me of surgery (interquar le range 13.2-28.2 years) received a bioprosthesis, 10 pa ents with a median age of 36.4 years (interquar le range 14.0-47.0) at me of surgery received amechanical prosthesis (p = 0.28). During a mean follow-up of 14 years, 50% needed a re-replacement because of valve-related complica ons (e.g. valve degenera on or valve thrombosis). The yearly percentage of pa ents with valve-related complica ons was 4.2% in pa ents with a bioprosthesis, and 2.7% in pa ents with a mechanical prosthesis. Within 20 years of implanta on, median dura on of event-free survival was significantly shorter in 3 pa ents with prosthesis-pa ent mismatch (1.0 year; interquar le range 0.01-2.6) compared to 7 pa ents without mismatch (8.0 years; interquar le range 5.1-12.3) (p = 0.02). Conclusions Compared to previous literature on acquired valvar disease, we found a higher incidence of valve-related complica ons in pa entswith congenital heart disease that was unrelated to prosthesis material. Our data suggests that prosthesis-pa ent mismatch may have a nega ve effect on the event-free interval.
Parental and peer support and modelling in relation to domain-specific physical activity participation in boys and girls from Germany

Background Physical activity (PA) as a precondition of child development is related with social environmental correlates. However, domain-specific PA and gender issues have been neglected in studies on social support and modelling and PA in school-aged children. The aim of this study was to assess the relationships of parental and peer modelling and social support with domain-specific PA participation in a large sample of school-aged children, taking gender into account. Methods 3,505 school children aged 6 to 17 years old participated in the German nationwide ‘MoMo’ cohort-study. By using the MoMo-PAQ the participants and their parents provided self-report data on perceived social support and social modelling and domain-specific PA participation. Relationships of social environmental variables and the physical outcomes were analysed by logistic regression analyses. Results At secondary school level, girls were less likely than boys to participate in physical activity in and outside of sports clubs, extra-curricular physical activity and in outdoor play (p < 0.05), but at primary school level this pattern only applied to club sport (p < 0.01). Girls also received less social support than boys (p < 0.01). Physical activity participation in all domains was associated with any of the social support and modelling variables and differences between physical activity domains and between boys and girls occurred. Most consistently physical activity in sports clubs was related with the social environmental correlates in boys (primary school: R2 = 0.60; secondary school: R2 = 0.45) and girls (primary school: R2 = 0.53; secondary school: R2 = 0.47). Conclusions In future, reciprocal relationships of social environmental variables and PA should be considered in longitudinal studies to obtain insights into the direction of the associations. Furthermore, interventions encompassing the social environment and focussed particularly on the promotion of domain-specific PA in girls in secondary school-age are warranted.
Complex Non-sinus-associated Pachymeningeal Lymphatic Structures: Interrelationship With Blood Microvasculature

The contribution of cranial dura mater vascular networks, as means for maintaining brain fluid movement and balance, and as the source of significant initiators and/or contributors to neurological disorders, has been overlooked. These networks consist of both blood and lymphatic vessels. The latter were discovered recently and described as sinus-associated structures thus changing the old paradigm that central nervous system lacks lymphatics. In this study, using markers specific to blood and lymphatic endothelia, we demonstrate the existence of the complex non-sinus-associated pachymeningeal lymphatic vasculature. We further show the interrelationship and possible connections between lymphatic vessels and the dural blood circulatory system. Our novel findings reveal the presence of lymphatic-like structures that exist on their own and/or in close proximity to microvessels. Of particular interest are sub-sets of vascular complexes with dual (lymphatic and blood) vessel identity representing a unique microenvironment within the cranial dura. The close association of the systemic blood circulation and meningeal lymphatics achieved in these complexes could facilitate fluid exchange between the two compartments and constitute an alternative route for CSF drainage.
Teachers Between Job Satisfaction and Burnout Syndrome: What Makes Difference in Czech Elementary Schools

As has been shown by several studies, teaching is a highly stressful occupation (Johnson et al., 2005), and most teachers experience work stress. Long-term stress decreases job satisfaction and can result in chronic exhaustion which can develop into burnout syndrome. Implications of burnout syndrome are strongly negative both for the personal and professional life of teachers. As burnout syndrome puts teachers’ well-being, quality of the teaching process and relationships with students at risk, it is important to seek ways to avoid teachersÉ’ burnout. Many studies have confirmed the protective role that coping strategies play in managing stressful situations, teacher’s self-efficacy or social support. In previous studies, a negative connection was found between burnout syndrome and job satisfaction. Job satisfaction is a crucial element in the definition of wellbeing. We find wellbeing rather not as a resource for burnout prevention but as an opposite state to burnout syndrome. The paper presents a quantitative survey on burnout syndrome and related variables among Czech elementary school teachers (n = 2,394). According to burnout score, two subgroups were selected – teachers with no burnout manifestations and teachers with developing/developed burnout syndrome. Through the statistical analysis, these two groups were compared in job satisfaction, self-efficacy, coping strategies, and social support. The study shows significant differences between the two groups of teachers in all examined variables. The strongest impact on burnout syndrome was found for negative coping.
Linear-Regression on Packed Encrypted Data in the Two-Server Model

Developing machine learning models from federated training data, containing many independent samples, is an important task that can significantly enhance the potential applicability and prediction power of learned models. Since single users, like hospitals or individual labs, typically collect data-sets that do not support accurate learning with high confidence, it is desirable to combine data from several users without compromising data privacy. In this paper, we develop a privacy-preserving solution for learning a linear regression model from data collectively contributed by several parties ("data owners''). Our protocol is based on the protocol of Giacomelli et al. (ACNS 2018) that utilized two non colluding servers and Linearly Homomorphic Encryption (LHE) to learn regularized linear regression models. Our methods use a different LHE scheme that allows us to significantly reduce both the number and runtime of homomorphic operations, as well as the total runtime complexity. Another advantage of our protocol is that the underlying LHE scheme is based on a different (and post-quantum secure) security assumption than Giacomelli et al. Our approach leverages the Chinese Remainder Theorem, and Single Instruction Multiple Data representations, to obtain our improved performance. For a 1000 x 40 linear regression task we can learn a model in a total of 3 seconds for the homomorphic operations, compared to more than 100 seconds reported in the literature. Our approach also scales up to larger feature spaces: we implemented a system that can handle a 1000 x 100 linear regression task, investing minutes of server computing time after a more significant offline pre-processing by the data owners. We intend to incorporate our protocol and implementations into a comprehensive system that can handle secure federated learning at larger scales.