Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effects of Interday Rest on Adaptation to 6 Weeks of Plyometric Training in Young Soccer Players

Abstract Ramírez-Campillo, R, Meylan, CMP, Álvarez-Lepín, C, Henriquez-Olguín, C, Martinez, C, Andrade, DC, Castro-Sepúlveda, M, Burgos, C, Baez, EI, and Izquierdo, M. The effects of interday rest on adaptation to 6 weeks of plyometric training in young soccer players. J Strength Cond Res 29(4): 972–979, 2015—The purpose of this study was to determine the effects of short-term plyometric training interposed with 24 or 48 hours of rest between training sessions on explosive and endurance adaptations in young soccer players. A total of 166 players, between 10 and 17 years of age, were randomly divided into 3 groups: a control group (CG; n = 55) and 2 plyometric training groups with 24 hours (PT24; n = 54) and 48 hours (PT48; n = 57) of rest between training sessions. Before and after intervention, players were measured in squat jump, countermovement jump, 20 (RSI20) cm drop jump reactive strength index, broad long jump, 20-m sprint time, 10 × 5-m agility time, 20-m multistage shuttle run test, and sit-and-reach test. The plyometric training program was applied during 6 weeks, 2 sessions per week, with a load from 140 to 260 jumps per session, replacing some soccer-specific drills. After intervention, the CG did not show significant performance changes. PT24 and PT48 groups showed a small-to-moderate significant improvement in all performance tests (p < 0.001), with no differences between treatments. Although it has been recommended that plyometric drills should not be conducted on consecutive days, the study shows that plyometric training applied twice weekly on consecutive or nonconsecutive days results in similar explosive and endurance adaptations in young male soccer players.
Financial Crises, Output Losses, and the Role of Structural Reforms

Financial crises take a heavy toll on output growth. We assess the role of structural reforms in reducing the output losses resulting from financial crises across advanced economies, emerging and developing economies, and low‐income developing economies. We also revisit the role of macroeconomic policies in this context. The impact of crises on output growth differs between types of crises and economies, thus warranting sample splits along these lines. Some but not all reforms and policies help to reduce the output losses of crises in the medium term, highlighting the need not to overgeneralize the effectiveness of reforms and policies. Further research is warranted to further explore the heterogeneity in the impact of financial crises on output growth and to better understand when and how specific structural reforms and macroeconomic policies can mitigate the output costs of financial crises. (JEL E32, E44, E63, G28, O47)
Borrelia burgdorferi‐associated cutaneous marginal zone lymphoma: a clinicopathological study of two cases illustrating the temporal progression of B. burgdorferi‐associated B‐cell proliferation in the skin

A relationship between Borrelia burgdorferi and primary cutaneous B‐cell lymphoma (PCBCL) has recently been confirmed following demonstration of the organism in lesional skin of patients with PCBCL. We report herein two cases of B. burgdorferi‐associated PCBCL which strengthen this association by demonstrating the organism in cutaneous B‐cell infiltrates present at sites in which PCBCL subsequently developed.
Extracting and Evaluating Features from RNA Virus Sequences to Predict Host Species Susceptibility Using Deep Learning

Identifying and monitoring hosts of zoonotic RNA viruses, that is, RNA viruses which can be transmitted from one species to another, including the recent SARS-CoV-2 causing the COVID-19 pandemic, is paramount to control their spread. However, efforts to control such spread may be affected if there are unmonitored or unknown hosts. To help identify potential hosts that may harbour such zoonotic viruses, we propose a pipeline that extracts features from sequences of RNA viruses, then uses the extracted features with deep learning to predict host species susceptibility. In addition to using sequence-related features, our method also extracts and uses features derived from the RNA secondary structures that can be formed by the viral sequences, since RNA secondary structures are known to take part in virus-host interaction. We evaluated the performance of our method and the different extracted features with a dataset containing RNA virus sequences and the host they infect, regardless of the viral species, from the NCBI Virus database. Using 10-fold cross validation, we found that a combination of the extracted features yielded the highest overall prediction accuracy of 86.89%.
Digital Dominance: The Power of Google, Amazon, Facebook and Apple

Across the globe, Google, Amazon, Facebook, Apple and Microsoft have accumulated power in ways that existing regulatory and intellectual frameworks struggle to comprehend. A consensus is emerging that the power of these new digital monopolies is unprecedented, and that it has important implications for journalism, politics, and society. It is increasingly clear that democratic societies require new legal and conceptual tools if they are to adequately understand, and if necessary check the economic might of these companies. Equally, that we need to better comprehend the ability of such firms to control personal data and to shape the flow of news, information, and public opinion. In this volume, Martin Moore and Damian Tambini draw together the world's leading researchers to examine the digital dominance of technologies platforms and look at the evidence behind the rising tide of criticism of the tech giants. In fifteen chapters, the authors examine the economic, political, and social impacts of Google, Amazon, Facebook, Apple, and Microsoft, in order to understand the different facets of their power and how it is manifested. Digital Dominance is the first interdisciplinary volume on this topic, contributing to a conversation which is critical to maintaining the health of democracies across the world.
Physicians' Estimates of the Probability of Myocardial Infarction in Emergency Boom Patients with chest Pain

To evaluate the ability of emergency room physicians to estimate the probability of myocardial infarction in patients with acute chest pain, the authors gathered historical, physical, and electrocardiographic information from 492 patients at the time of their presentation. The physicians admitted 30% of them to intensive care: 53 of the 61 patients with infarctions (sensitivity = 87%) and 96 of the 431 without infarctions (specificity = 78%). Overall, 36% of those admitted had infarctions. The physicians' numeric estimate of the probability of infarction was a good univariate discriminator of infarction, as demonstrated by Receiver Operator Characteristics analysis, and, as indicated by their actual operating point, they seemed to maximize the accuracy of patient classification rather than sensitivity or specificity. Logistic regression analysis identified the physicians' probability estimate as the strongest multivariate predictor of infarction, considering all other clinical information available. Key words: probability; prediction; myocardial infarction. (Med Decis Making 6:12-17, 1986)
Napping, development and health from 0 to 5 years: a systematic review

Background Duration and quality of sleep affect child development and health. Encouragement of napping in preschool children has been suggested as a health-promoting strategy. Objectives The aim of this study is to assess evidence regarding the effects of napping on measures of child development and health. Design This study is a systematic review of published, original research articles of any design. Subjects Children aged 0–5 years. Method Electronic database search was performed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and assessment of research quality was carried out following a Grading of Recommendations, Assessment, Development and Evaluations (GRADE) protocol. Results Twenty-six articles met inclusion criteria. These were of heterogeneous quality; all had observational designs (GRADE-low). Development and health outcomes included salivary cortisol, night sleep, cognition, behaviour, obesity and accidents. The findings regarding cognition, behaviour and health impacts were inconsistent, probably because of variation in age and habitual napping status of the samples. The most consistent finding was an association between napping and later onset, shorter duration and poorer quality of night sleep, with evidence strongest beyond the age of 2 years. Limitations Studies were not randomised. Most did not obtain data on the children's habitual napping status or the context of napping. Many were reliant on parent report rather than direct observation or physiological measurement of sleep behaviour. Conclusions The evidence indicates that beyond the age of 2 years napping is associated with later night sleep onset and both reduced sleep quality and duration. The evidence regarding behaviour, health and cognition is less certain. There is a need for more systematic studies that use stronger designs. In preschool children presenting with sleep problems clinicians should investigate napping patterns.
“Cytokine Storm” in the Phase I Trial of Monoclonal Antibody TGN1412: Better Understanding the Causes to Improve PreClinical Testing of Immunotherapeutics

The CD28-specific mAb TGN1412 rapidly caused a life-threatening “cytokine storm” in all six healthy volunteers in the Phase I clinical trial of this superagonist, signaling a failure of preclinical safety testing. We report novel in vitro procedures in which TGN1412, immobilized in various ways, is presented to human white blood cells in a manner that stimulates the striking release of cytokines and profound lymphocyte proliferation that occurred in vivo in humans. The novel procedures would have predicted the toxicity of this superagonist and are now being applied to emerging immunotherapeutics and to other therapeutics that have the potential to act upon the immune system. Data from these novel procedures, along with data from in vitro and in vivo studies in nonhuman primates, suggest that the dose of TGN1412 given to human volunteers was close to the maximum immunostimulatory dose and that TGN1412 is not a superagonist in nonhuman primates.
MR ratio enhancement by NOL current-confined-path structures in CPP spin valves

We have compared the magnetoresistance (MR) performance of current-confined-path (CCP) current-perpendicular-to-plane giant magnetoresistance (CPP-GMR) spin valve films with a nano-oxide-layer (NOL), made between natural oxidation (NO) and ion-assisted oxidation (IAO). For the NO, an MR ratio was only 1.5% at an RA of 370 m/spl Omega//spl mu/m/sup 2/, whereas for the IAO, an MR ratio was greatly increased to 5.4% at an RA of 500 m/spl Omega//spl mu/m/sup 2/. Fitted data by the Valet-Fert model showing larger MR enhancement effect by the IAO is explained by the improvement of the metal-purity of the Cu inside the CCP structure. By further improvement of metal-purity of the Cu, a large MR ratio of more than 30% can be expected at a small RA of 300 m/spl Omega//spl mu/m/sup 2/. The CCP-CPP spin valve film is a promising candidate for realizing high-density recording heads for 200 to 400-Gbpsi recording.
Three-dimensional structure of baculovirus-expressed Norwalk virus capsids

The three-dimensional structure of the baculovirus-expressed Norwalk virus capsid has been determined to a resolution of 2.2 nm using electron cryomicroscopy and computer image processing techniques. The empty capsid, 38.0 nm in diameter, exhibits T = 3 icosahedral symmetry and is composed of 90 dimers of the capsid protein. The striking features of the capsid structure are arch-like capsomeres, at the local and strict 2-fold axes, formed by dimers of the capsid protein and large hollows at the icosahedral 5- and 3-fold axes. Despite its distinctive architecture, the Norwalk virus capsid has several similarities with the structures of T = 3 single-stranded RNA (ssRNA) viruses. The structure of the protein subunit appears to be modular with three distinct domains: the distal globular domain (P2) that appears bilobed, a central stem domain (P1), and a lower shell domain (S). The distal domains of the 2-fold related subunits interact with each other to form the top of the arch. The lower domains of the adjacent subunits associate tightly to form a continuous shell between the radii of 11.0 and 15.0 nm. No significant mass density is observed below the radius of 11.0 mm. It is suspected that the hinge peptide in the adjoining region between the central domain and the shell domain may facilitate the subunits adapting to various quasi-equivalent environments. Architectural similarities between the Norwalk virus capsid and the other ssRNA viruses have suggested a possible domain organization along the primary sequence of the Norwalk virus capsid protein. It is suggested that the N-terminal 250 residues constitute the lower shell domain (S) with an eight-strand beta-barrel structure and that the C-terminal residues beyond 250 constitute the protruding (P1+P2) domains. A lack of an N-terminal basic region and the ability of the Norwalk virus capsid protein to form empty T = 3 shells suggest that the assembly pathway and the RNA packing mechanisms may be different from those proposed for tomato bushy stunt virus and southern bean mosaic virus but similar to that in tymoviruses and comoviruses.
THE EFFECT OF LEADERSHIP STYLES ON EMPLOYEES’ PSYCHOLOGICAL EMPOWERMENT AND THE GENDER ROLE IN THIS RELATION

Purpose - The purpose of the study is to identify the impact of three leadership style (paternalistic, transformational and transactional) on psychological empowerment and the moderating effect of gender. Methodology - The Survey method was used to gather data from 97 people working in middle and lower levels in various organizations and the analysis was conducted with SPSS 19. Four validated survey instruments were used to obtain the data: (1) The Multifactor Leadership Questionnaire (MLQ), formulated by Bass and Avolio (1995), (2) The Paternalistic Leadership Scale developed by Voich (1995), (3) The Global Transformational Leadership Scale (GTL) developed by Carless, Wearing and Mann(2000) and (4) The Psychological Empowerment Scale developed by Spreitzer (1995). Findings- The study shows that there is a positive but partial relationship between the Transformational Leadership style and Psychological Empowerment, but there is no relationship between Paternalistic Leadership, Transactional Leadership as predicted. Conclusion- Transformational leadership style has been identified as one of the most important ways to empower employees in organizations in the light of findings.
Investigational agents for the irritable bowel syndrome

Importance of the field: Irritable bowel syndrome (IBS) is a common disorder with significant health and economic consequences. The etiology of IBS is complex and appears to be multifactorial. Traditional IBS therapies have been directed primarily at the relief of individual symptoms but have been largely disappointing. This has triggered the search for newer treatment strategies with improved patient outcomes. Areas covered in this review: Enhanced knowledge about the putative pathophysiology of IBS has allowed the identification of new mechanistic targets for treatment. Our aim is to review emerging and promising drugs in the treatment of IBS based on disease pathophysiology. Data were extracted using Medline and PubMed search engines until January 2010. Abstracts were identified through ‘Web of Science’ and abstract supplements of major gastrointestinal scientific meetings. Drugs were classified according to mechanism of action and those with efficacy in trials involving human subjects examined. What the reader will gain: Additional insight into the pathophysiology as well as current and prospective treatments of IBS. Take home message: A multitude of putative drug targets have been identified and some novel treatments have progressed through to human clinical trials, but very few will be approved for the market in the near future. Moreover, and in keeping with the complex and multifactorial nature of this syndrome, it is unlikely that there will be one dominant and universally effective form of therapy for all IBS patients.
The mannose-binding lectin gene FaMBL1 is involved in the resistance of unripe strawberry fruits to Colletotrichum acutatum.

The fungal pathogen Colletotrichum acutatum is the causal agent of strawberry (Fragaria × ananassa) anthracnose. Although the fungus can infect strawberry fruits at both unripe and ripe stages, the symptoms appear only on red ripe fruits. On white unripe fruits, the pathogen becomes quiescent as melanized appressoria after 24 h of interaction. Previous transcriptome analysis has indicated that a mannose-binding lectin (MBL) gene is the most up-regulated gene in 24-h-infected white strawberries, suggesting a role for this gene in the low susceptibility of unripe stages. A time course analysis of the expression of this MBL gene, named FaMBL1 (Fragaria × ananassa MBL 1a), was undertaken to monitor its expression profile in white and red fruits at early interaction times: FaMBL1 was expressed exclusively in white fruit after 24 h, when the pathogen was quiescent. Agrobacterium-mediated transient transformation was used to silence and overexpress the FaMBL1 gene in 24-h-infected white and red strawberries, respectively. FaMBL1-silenced unripe fruits showed an increase in susceptibility to C. acutatum. These 24-h-infected tissues contained subcuticular hyphae, indicating pathogen penetration and active growth. In contrast, overexpression of FaMBL1 in ripe fruits decreased susceptibility; here, 24-h-infected tissues showed a high percentage of ungerminated appressoria, suggesting that the growth of the pathogen had slowed. These data suggest that FaMBL1 plays a crucial role in the resistance of unripe strawberry fruits to C. acutatum.
A vir-repressed gene of Bordetella pertussis is required for virulence

Coordinate regulation of gene expression in Bordetella pertussis is controlled by the products of the vir locus, BvgA and BvgS. In the presence of modulating signals such as MgSO4 and nicotinic acid, expression of vir-activated genes (vag) is reduced, while expression of vir-repressed genes (vrg) is maximal. We have cloned one of these vir-repressed genes, vrg-6, in Escherichia coli. DNA sequencing has shown that vrg-6 is contained on a single EcoRI restriction endonuclease fragment and is predicted to code for a protein of 105 amino acids with a molecular weight of 11,441. The predicted protein product appears to have two domains, one consisting of seven hydrophobic proline-rich pentameric repeats and the other consisting of five alkaline trimeric repeats. Southern blot analysis has revealed vrg-6-homologous sequences in the chromosomes of Bordetella bronchiseptica and Bordetella parapertussis, but, unlike Bordetella pertussis, these species do not express vrg-6-homologous RNA when grown under modulating conditions. In order to assess the role of vrg gene products in B. pertussis pathogenesis, two 18323 derivatives which harbor TnphoA insertions in vrg genes were analyzed in a mouse model of respiratory infection. Strain SK6, which carries a vrg-6::TnphoA mutation, failed to induce lymphocytosis and was significantly less able to colonize lungs and trachea than its parent strain 18323 or than SK18, which harbors a TnphoA fusion in the vrg-18 locus. This is the first evidence that a vir-repressed gene may play an important role in the virulence of B. pertussis and the pathogenesis of whooping cough.
Organizational Justice, Task And Contextual Performance: Empirical Analysis For Front Line Managers

Organizational justice-performance relationships have been extensively explored and some significant relationships are reported between procedural and distribute justice with employee performance around the globe. This paper aims at exploring justice-performance relationships particularly for front line managers in Pakistani Textile industry. Organizational justices such as procedural and distributive justice are examined with individual performance of employees which is measured as task and contextual performance including citizenship behaviour. A randomly selected sample of 352 front line managers from 20 textile organization through stratified sampling has been collected for the purpose of data analysis. Results show that both procedural and distributive justices have significant and positive relationships with task and contextual performance including citizenship behaviour. However, relatively stronger strengths of relationships are found between justice measures and contextual performance including citizenship behaviour in comparison to task performance of front line managers. The findings of the study visibly contribute toward conceptual as well as theoretical understanding of justice-performance relationships particularly in developing economies.
Maximum likelihood regression tree with two-variable splitting scheme for subway incident delay

ABSTRACT Considering possible variable interaction effects, this study develops a maximum likelihood regression tree-based (MLRT) model using the proposed two-variable splitting method to describe subway incident delays. A MLRT comprising 13 leaf nodes is built with Hong Kong subway incident data from 2005 to 2012 and a log-logistic distributed accelerated failure time (AFT) model is developed separately for each leaf node. The comparison of model performance indicates that our developed model outperforms traditional AFT models and the tree-based model building based on the traditional single-variable splitting scheme. The probability of subway incident delay being unacceptable can be predicted using our developed model, which can be utilized as a basis for alerting commuters to the necessity of rescheduling their trips in the event of a subway incident.
Regulation of Leucine-stimulated Insulin Secretion and Glutamine Metabolism in Isolated Rat Islets*

Glutamate dehydrogenase (GDH) is regulated by both positive (leucine and ADP) and negative (GTP and ATP) allosteric factors. We hypothesized that the phosphate potential of β-cells regulates the sensitivity of leucine stimulation. These predictions were tested by measuring leucine-stimulated insulin secretion in perifused rat islets following glucose depletion and by tracing the nitrogen flux of [2-15N]glutamine using stable isotope techniques. The sensitivity of leucine stimulation was enhanced by long time (120-min) energy depletion and inhibited by glucose pretreatment. After limited 50-min glucose depletion, leucine, not α-ketoisocaproate, failed to stimulate insulin release. β-Cells sensitivity to leucine is therefore proposed to be a function of GDH activation. Leucine increased the flux through GDH 3-fold compared with controls while causing insulin release. High glucose inhibited flux through both glutaminase and GDH, and leucine was unable to override this inhibition. These results clearly show that leucine induced the secretion of insulin by augmenting glutaminolysis through activating glutaminase and GDH. Glucose regulates β-cell sensitivity to leucine by elevating the ratio of ATP and GTP to ADP and Pi and thereby decreasing the flux through GDH and glutaminase. These mechanisms provide an explanation for hypoglycemia caused by mutations of GDH in children.