Miracle-dz/UniFAR-FTUs huggingface dataset:
Progressive Multifocal Leukoencephalopathy: a rare infectious complication following allogeneic hematopoietic cell transplantation (HCT)

Progressive multifocal leukoencephalopathy (PML), a demyelinating disorder caused by brain infection with JC virus, is a neurological complication of immunocompromised states and immunosuppressive therapies. While most commonly seen in the HIV/AIDS population, patients with hematologic malignancies are also at risk following treatment protocols including monoclonal antibodies such as rituximab and after hematopoietic stem cell transplantation. Here, we present the case of PML following allogeneic HCT that highlights potential diagnostic difficulties. We also review the literature regarding PML following HCT and described therapies employed to attempt to treat this disorder.
4‐1BB triggers IL‐13 production from T cells to limit the polarized, Th1‐mediated inflammation

4‐1BB (CD137) triggering typically induces Th1 response by increasing IFN‐γ from T cells upon TCR ligation. We found recently that 4‐1BB costimulation increased the expression of IL‐13 from CD4+ T cells, as well as CD8+ T cells. The enhanced IL‐13 expression by agonistic anti‐4‐1BB treatment was mediated via MAPK1/2, PI‐3K, JNK, mammalian target of rapamycin, NF‐AT, and NF‐κB signaling pathways. The signaling for IL‐13 induction was similar to that of IFN‐γ production by anti‐4‐1BB treatment in T cells. When the anti‐4‐1BB‐mediated IL‐13 expression was tested in an in vivo viral infection model such as HSV‐1 and vesicular stomatitis virus, 4‐1BB stimulation enhanced IL‐13 expression of CD4+ T, rather than CD8+ T cells. Although IL‐13 was enhanced by anti‐4‐1BB treatment, the increased IL‐13 did not significantly alter the anti‐4‐1BB‐induced Th1 polarization of T cells—increase of T‐bet and decrease of GATA‐3. Nevertheless, anti‐4‐1BB treatment polarized T cells excessively in the absence of IL‐13 and even became detrimental to the mice by causing liver inflammation. Therefore, we concluded that IL‐13 was coinduced following 4‐1BB triggering to maintain the Th1/2 balance of immune response.
Induction of Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen by the Lytic Transactivator RTA: a Novel Mechanism for Establishment of Latency

ABSTRACT Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent contributing to development of Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman desease. Following primary infection, latency is typically established. However, the mechanism by which KSHV establishes latency is not understood. We have reported that the latency-associated nuclear antigen (LANA) can repress RTA (for replication and transcription activator) expression by down-regulating its promoter. In this study, we show that RTA is associated with the virion particle. We also show that RTA can activate the LANA promoter and induce LANA expression in transient reporter assays. Additionally, the transcription of RTA correlates with LANA expression in the early stages of de novo infection of KSHV, and induction of LANA transcription is responsive to induction of RTA with an inducible system. This induction in LANA transcription was dependent on recombination signal sequence binding protein Jκ (RBP-Jκ), as a RBP-Jκ-deficient cell line was significantly delayed and inefficient in LANA transcription with expression of RTA. These studies suggest that RTA contributes to establishment of KSHV latency by activating LANA expression in the early stages of infection by utilizing the major effector of the Notch signaling pathway RBP-Jκ. This describes a feedback mechanism by which LANA and RTA can regulate each other and is likely to be a key event in the establishment of KSHV latency.
To Your Health: Health Insurance, Self‐Employment Exit, and Older Entrepreneurs

Drawing on a sample of 5,238 individuals in the Health and Retirement Study, we examined the relationship between having one's own health insurance and exit from self‐employment to employment. Our results indicate that individuals who have health insurance are less likely to exit self‐employment. When self‐employed individuals have their own health insurance, males, relative to females, are more likely to exit self‐employment. Additionally, when self‐employed individuals have their own health insurance, those who do not have health problems that limit work are more likely to exit. We discuss the implications that these findings have on the literature and policymakers.
Effect of Wearable Technology Combined With a Lifestyle Intervention on Long-term Weight Loss: The IDEA Randomized Clinical Trial.

Importance Effective long-term treatments are needed to address the obesity epidemic. Numerous wearable technologies specific to physical activity and diet are available, but it is unclear if these are effective at improving weight loss. Objective To test the hypothesis that, compared with a standard behavioral weight loss intervention (standard intervention), a technology-enhanced weight loss intervention (enhanced intervention) would result in greater weight loss. Design, Setting, Participants Randomized clinical trial conducted at the University of Pittsburgh and enrolling 471 adult participants between October 2010 and October 2012, with data collection completed by December 2014. Interventions Participants were placed on a low-calorie diet, prescribed increases in physical activity, and had group counseling sessions. At 6 months, the interventions added telephone counseling sessions, text message prompts, and access to study materials on a website. At 6 months, participants randomized to the standard intervention group initiated self-monitoring of diet and physical activity using a website, and those randomized to the enhanced intervention group were provided with a wearable device and accompanying web interface to monitor diet and physical activity. Main Outcomes and Measures The primary outcome of weight was measured over 24 months at 6-month intervals, and the primary hypothesis tested the change in weight between 2 groups at 24 months. Secondary outcomes included body composition, fitness, physical activity, and dietary intake. Results Among the 471 participants randomized (body mass index [BMI], 25 to <40; age range, 18-35 years; 28.9% nonwhite, 77.2% women), 470 (233 in the standard intervention group, 237 in the enhanced intervention group) initiated the interventions as randomized, and 74.5% completed the study. For the enhanced intervention group, mean base line weight was 96.3 kg (95% CI, 94.2-98.5) and 24-month weight 92.8 kg (95% CI, 90.6- 95.0) [corrected]. For the standard intervention group, mean baseline weight was 95.2kg (95%CI,93.0-97.3)and24-month weight was 89.3 kg (95%CI, 87.1-91.5) [corrected]. Weight change at 24 months differed significantly by intervention group (estimated mean weight loss, 3.5 kg [95% CI, 2.6-4.5} in the enhanced intervention group and 5.9 kg [95% CI, 5.0-6.8] in the standard intervention group; difference, 2.4 kg [95% CI, 1.0-3.7]; P = .002). Both groups had significant improvements in body composition, fitness, physical activity, and diet, with no significant difference between groups. Conclusions and Relevance Among young adults with a BMI between 25 and less than 40, the addition of a wearable technology device to a standard behavioral intervention resulted in less weight loss over 24 months. Devices that monitor and provide feedback on physical activity may not offer an advantage over standard behavioral weight loss approaches. Trial Registration clinicaltrials.gov Identifier: NCT01131871.
Interaction between Business Cycles and Economic Growth

In the aftermath of the recent global financial crisis, advanced economies have faced sluggish recoveries or long-lasting economic slowdowns. This experience has challenged the conventional dichotomy of business cycles and economic growth, which has long been central to macroeconomic analysis. Against this backdrop, we review the literature looking at the relationship between business cycles and economic growth. This study consists of three parts. First, we provide basic ideas about the relationship of business cycles and economic growth, and a simple empirical analysis on economic growth rates in advanced economies. Second, we survey studies which look at the effects of business cycles on economic growth. Specifically, we focus on hysteresis effects caused by labor market structure, firm activity and fiscal policy. Third, we review the literature looking at the effects of economic growth on business cycles, through mechanisms such as technological progress and population ageing.
Distribution of Legionella Species from Environmental Water Sources of Public Facilities and Genetic Diversity of L. pneumophila Serogroup 1 in South Korea

ABSTRACT A total of 560 Legionella species were isolated from environmental water sources from public facilities from June to September 2008 throughout South Korea. The distribution of Legionella isolates was investigated according to geographical region, facility type, and sample type. The genetic diversity of 104 isolates of Legionella pneumophila serogroup 1 (sg 1) was analyzed by sequence-based typing (SBT). L. pneumophila was distributed broadly throughout Korea, accounting for 85.0% of the isolates, and L. pneumophila sg 1 predominated in all of the public facilities except for the springs. Legionella anisa and Legionella bozemanii predominated among non-L. pneumophila species (48.1% and 21.0%, respectively). The second most dominant strain differed depending on the facility type: L. anisa was the second most dominant strain in the buildings (10.8%), L. pneumophila sg 5 in public baths (21.6%), L. pneumophila sg 6 in factories (12.0%), and L. pneumophila sg 7 in hospitals (13.1%). In the SBT analysis, 104 L. pneumophila sg 1 isolates were differentiated into 26 sequence types (STs) and categorized into 3 clonal groups (CGs) and 10 singleton STs via the eBURST V3 program. ST1, a potential founder of major CG1, was commonly distributed (48.1%). The dominant ST in hot water was ST-K1 (7, 12, 17, 3, 35, 11, 11), which was designated in this study (36.1%). The second most dominant strain differed depending on the type of facility from which the samples were obtained. The unique allelic profile of ST-K1, obtained from hot water, was not found in the European Working Group for Legionella Infections (EWGLI) SBT database.
Overreaction Market Analysis, Dividend Policy, Firm Size, and Seasonality to Price Reversal Phenomena

"Objective – In an efficient capital market, the price of a stock reflects the outstanding and relevant information. However, some studies find that is the capital markets are not always efficient. Sometimes investors put too high a price, good news and vice versa. That’s why there are variety of capital market anomalies such as the price reversal. This research, test share return following one day a big change of the share price in the Indonesia capital market. Methodology/Technique – The unit of analysis in this study are the stocks that listed in the Jakarta Islamic Index. Then we used purposive sampling method for sampling and 21 samples obtained shares. These samples, then classified into 11 shares 10 shares winner and a loser. Analysis the user is paired sample t-test and doubled regression. In addition, double regression analysis with market overreaction, dividend policy, firm size and the January effect as independent variables and price reversal as the dependent variable. Findings – Regression test showed that in the group winner stocks, market overreaction, firm size and January effect have an effect on signs of price reversal. And dividend policy has no significant influence. For the group of loser stocks, market overreaction, dividend policy, firm size and January effect affect both simultaneously and partially on price reversal. Novelty – The study contributes decision making of investors in Indonesia financial market with its evidences. "
Employment Equity and Institutional Commitments to Diversity: Disciplinary Perspectives from Public Administration and Public Affairs Education

Abstract Are racism and discrimination forgotten issues in public administration research on the promotion of diversity in graduate education and faculty employment? Studies touching on diversity and employment equity usually address subjects such as education and training—the competencies needed by professional administrators, for example—as well as best practices in diversity management, persistent problems such as the lack of racial or gender diversity in upper management positions in public sector agencies, and the enduring challenges of minority recruitment and retention in public administration programs. The subjects of racism and discrimination as such—or of underlying factors generally—are seldom addressed centrally. Consequently, questions such as the following arise: What role might racism play in academic as well as public sector employment? What about other lines of causation impacting discrimination? How do individual, group, and institutional predispositions and actions affect employment equity? How have such questions been addressed in the public administration literature? In other research and research applications in the social, behavioral, and management sciences? And, finally, what can be learned from successful and failed diversity-promotion practices among academic programs? A significant body of empirical research is uncovering patterns of action that have the intended or unintended effect of excluding candidates of color from recruitment pools, interview short-lists, and faculty hiring and advancement opportunities. This essay reviews and analyzes some of this literature, particularly as it relates to public affairs education. On that basis, it suggests the following: (1) new directions for diversity-related research, (2) changes in the articulation of diversity commitments, particularly by public administration departments and programs, and (3) ways to successfully realize those institutional commitments (assuming that they are more than rhetorical), pointing to research that specifies proven practices.
Human and mouse GPAA1 (Glycosylphosphatidylinositol anchor attachment 1) genes: genomic structures, chromosome loci and the presence of a minor class intron

Many eukaryotic cell surface proteins are anchored to the membrane with glycosylphosphatidylinositol (GPI) that is covalently linked to the carboxyl-terminus. A Saccharomyces cerevisiae gaa1 mutant is defective in posttranslational attachment of GPI to proteins. A recent report demonstrated that the GPAA1 gene encodes a component of a transamidase that mediates GPI-anchor attachment. Here, we report structures and chromosome loci of human and mouse GPAA1 genes. Both genes consist of twelve exons that span about 4 kb. Human and mouse GPAA1s are located at 8q24.3 and 15E, respectively. There is a human pseudo GPAA1 gene (GPAA1P1) that is located at 2q12→q14. Introns 8 of human and mouse GPAA1s were minor class introns bearing AT at the 5′ splice sites and AC and AT at the 3′ splice sites, respectively. The 3′ splice sites of corresponding introns of African green monkey, Chinese hamster, dog and rat were AC, AT, AT and AA, respectively. The mouse GPAA1 gene (Gpaa1) bearing AG at the 3′ splice site prepared by site-directed mutagenesis was functional, indicating that any nucleotide is allowed at the 3′ end of a minor class intron.
The poor “sociological imagination” of the rich: Explaining attitudinal divergence towards welfare, inequality, and redistribution

Quantitative research has tended to explain attitudinal divergence towards welfare and redistribution through self-interested rationalities. However, such an approach risks abstracting individuals from the structural determinants of resource allocation and biographical experience. With that in mind, this paper draws on a qualitative study of fifty individuals experiencing relative deprivation and affluence in the UK and New Zealand to examine how lived experiences of inequality affect attitude formation towards welfare and redistribution. Scenario-driven vignettes were used to stimulate an applied discussion of abstract principles pertaining to welfare and inequality. Use of this methodological device proffered novel insight into the phenomenological effects of material position on public attitudes and policy preferences in a comparative context. The findings suggest that affluent individuals are less likely to acknowledge systemic features shaping socio-economic life. As a result, they exhibit a poor sociological imagination that is deployed in distinct and patterned ways to make sense of, and at times justify, economic restructuring. By contrast, those living in relative deprivation are more likely to advance accounts of intergroup relations and social location that emphasise the structuration of (dis-) advantage. Based on the findings, policy and political implications are considered for welfare and redistribution amidst rising structural inequality.
Oscillatory Stability and Eigenvalue Sensitivity Analysis of A DFIG Wind Turbine System

This paper focuses on modeling and oscillatory stability analysis of a wind turbine with doubly fed induction generator (DFIG). A detailed mathematical model of DFIG wind turbine with vector-control loops is developed, based on which the loci of the system Jacobian's eigenvalues have been analyzed, showing that, without appropriate controller tuning a Hopf bifurcation can occur in such a system due to various factors, such as wind speed. Subsequently, eigenvalue sensitivity with respect to machine and control parameters is performed to assess their impacts on system stability. Moreover, the Hopf bifurcation boundaries of the key parameters are also given. They can be used to guide the tuning of those DFIG parameters to ensure stable operation in practice. The computer simulations are conducted to validate the developed model and to verify the theoretical analysis.
Hiding in plain sight: experiences of food insecurity and rationing in New Zealand

Abstract Neoliberal narratives dominate constructions of poverty. The dearth of alternative legitimizing narratives effectively silences the lived experiences of issues such as food insecurity. In conjunction with hegemonic silencing, feelings of shame and personal inadequacy further drive these experiences from public view. People living with poverty learn to hide their everyday realities from public scrutiny and engage in social practices in an effort to reduce experiences of stigma, oppression, and social rejection. As part of a larger study into food and poverty, this paper draws on interviews with five householders who source and provide food for their respective families. In doing so, it documents how lived experiences of food scarcity bring the often hidden aspects of marginalized lives into view. Householders utilize practices of passing and food rationing in order to navigate the shame and moral accusations associated with poverty.
"Primary" versus "secondary" vulvar vestibulitis: one disease, two variants.

OBJECTIVE Our aim was to determine whether women with primary vestibulitis-since the first episode of sexual intercourse-differ in disease characteristics and outcome of operative treatment from women with secondary vestibulitis. STUDY DESIGN A total of 111 patients with severe vulvar vestibulitis underwent perineoplasty from 1991 to 1995. Thirty-nine (35%) of them had primary vestibulitis (ie, dyspareunia from the first attempt at sexual intercourse). They were compared with 72 (65%) who had secondary vestibulitis with regard to demographic, social, and medical variables, the presence of human papillomavirus deoxyribonucleic acid, physical and histopathologic findings in the vestibule, and surgical outcome. RESULTS Women with primary vestibulitis were 5 years younger than those who had secondary vestibulitis (22.9 +/- 2.9 years vs 27.7 +/- 8.6 years, respectively; P <.0001) and differed in their marital status (unmarried, 84% vs 56%, respectively; P <.008), parity (nulliparous, 97% vs 67%, respectively; P <.0002), and involvement of the whole vestibule (74% vs 93%, respectively; P <.006). The 2 groups were similar in all other variables, including use of oral contraception, smoking, presence of human papillomavirus, dysuria, success of perineoplasty (average, 83%), and histopathologic findings. CONCLUSIONS Women with primary vestibulitis were younger than women with secondary vestibulitis. Most other differences were dependent on the different ages of the 2 groups. Primary and secondary vestibulitis may therefore be two presentations of the same disease.
Liver Cytochrome P450 3A Ubiquitination in Vivo by gp78/Autocrine Motility Factor Receptor and C Terminus of Hsp70-interacting Protein (CHIP) E3 Ubiquitin Ligases

CYP3A4 is a dominant human liver cytochrome P450 enzyme engaged in the metabolism and disposition of >50% of clinically relevant drugs and held responsible for many adverse drug-drug interactions. CYP3A4 and its mammalian liver CYP3A orthologs are endoplasmic reticulum (ER)-anchored monotopic proteins that undergo ubiquitin (Ub)-dependent proteasomal degradation (UPD) in an ER-associated degradation (ERAD) process. These integral ER proteins are ubiquitinated in vivo, and in vitro studies have identified the ER-integral gp78 and the cytosolic co-chaperone, CHIP (C terminus of Hsp70-interacting protein), as the relevant E3 Ub-ligases, along with their cognate E2 Ub-conjugating enzymes UBC7 and UbcH5a, respectively. Using lentiviral shRNA templates targeted against each of these Ub-ligases, we now document that both E3s are indeed physiologically involved in CYP3A ERAD/UPD in cultured rat hepatocytes. Accordingly, specific RNAi resulted in ≈80% knockdown of each hepatic Ub-ligase, with a corresponding ≈2.5-fold CYP3A stabilization. Surprisingly, however, such stabilization resulted in increased levels of functionally active CYP3A, thereby challenging the previous notion that E3 recognition and subsequent ERAD of CYP3A proteins required ab initio their structural and/or functional inactivation. Furthermore, coexpression in HepG2 cells of both CYP3A4 and gp78, but not its functionally inactive RING-finger mutant, resulted in enhanced CYP3A4 loss greater than that in corresponding cells expressing only CYP3A4. Stabilization of a functionally active CYP3A after RNAi knockdown of either of the E3s, coupled with the increased CYP3A4 loss on gp78 or CHIP coexpression, suggests that ERAD-associated E3 Ub-ligases can influence clinically relevant drug metabolism by effectively regulating the physiological CYP3A content and consequently its function.
An analysis of spontaneous hypertension in spontaneously hypertensive rats by means of new recombinant inbred strains.

The mode of blood pressure inheritance and some genetic markers of spontaneous hypertension were evaluated in a new set of recombinant inbred (RI) strains obtained by crossing of normotensive (BN.lx) and hypertensive (SHR) progenitor strains. Blood pressure values of RI strains were continuously distributed between both progenitor strains, although normotensive strains slightly prevailed. Statistical analysis suggested that there are three major genes and multiple minor genes responsible of the determination of spontaneous hypertension. The association between blood pressure and gene(s) within RT1 complex or gene(s) closely linked to it was found by RI strain analysis. This suggestion was confirmed by the detection of significant difference in blood pressure between SHR and SHR.1N congenic strains. Our results indicate that RT1 complex gene(s) may be involved in the development of high blood pressure.