Miracle-dz/UniFAR-FTUs huggingface dataset:
Immunoexpression of inhibin alpha subunit, inhibin/activin betaA subunit and CD99 in ovarian tumors.

OBJECTIVE Anti-inhibin alpha and inhibin/activin betaA subunit and anti-CD99 monoclonal antibodies (mAbs) have recently been demonstrated to be able to label ovarian granulosa cells; thus, they may be of value in the diagnosis of granulosa cell tumors. The present study aimed to determine what combination of these mAbs may be useful for the differential diagnosis of sex cord-stromal tumors of ovary. DESIGN Immunohistochemical analyses with anti-inhibin alpha and inhibin/activin betaA subunit antibody and anti-CD99 mAb were performed on 42 ovarian tumors, including sex cord-stromal tumors (29), ovarian epithelial cancers (10), and Krukenberg tumors (3). RESULTS All sex cord-stromal tumors were positive for inhibin alpha subunit, and 17 cases (58.6%) of sex cord-stromal tumors were immunoreactive for inhibin/activin betaA subunit. Epithelial tumors and Krukenberg tumors were all negative for inhibin/activin betaA subunit except mucinous carcinoma, which showed strong cytoplasmic immunoreactivity. All sex cord-stromal tumors except one granulosa cell tumor showed membranous staining for CD99. A case of serous carcinoma and a case of mucinous carcinoma were positive for CD99, and the remaining epithelial tumors and Krukenberg tumor were all negative for CD99. CONCLUSIONS The results of immunohistochemical analysis, together with literature review, suggest that inhibin alpha subunit may be a useful diagnostic marker for sex cord-stromal tumor of the ovary. In addition, anti-CD99 antibody may be useful for the differential diagnosis between ovarian tumors. Inhibin/activin betaA subunit has a limited usefulness in the differential diagnosis of ovarian tumor because of its wider immunoreactivity for both sex cord-stromal tumors and mucinous carcinomas. The differential diagnosis of sex cord-stromal tumors of the ovary would be better made with a combined use of both anti-inhibin alpha subunit and anti-CD99 mAbs.
Reconstitution in yeast of the Arabidopsis SOS signaling pathway for Na+ homeostasis

The Arabidopsis thaliana SOS1 protein is a putative Na+/H+ antiporter that functions in Na+ extrusion and is essential for the NaCl tolerance of plants. sos1 mutant plants share phenotypic similarities with mutants lacking the protein kinase SOS2 and the Ca2+ sensor SOS3. To investigate whether the three SOS proteins function in the same response pathway, we have reconstituted the SOS system in yeast cells. Expression of SOS1 improved the Na+ tolerance of yeast mutants lacking endogenous Na+ transporters. Coexpression of SOS2 and SOS3 dramatically increased SOS1-dependent Na+ tolerance, whereas SOS2 or SOS3 individually had no effect. The SOS2/SOS3 kinase complex promoted the phosphorylation of SOS1. A constitutively active form of SOS2 phosphorylated SOS1 in vitro independently of SOS3, but could not fully substitute for the SOS2/SOS3 kinase complex for activation of SOS1 in vivo. Further, we show that SOS3 recruits SOS2 to the plasma membrane. Although sos1 mutant plants display defective K+ uptake at low external concentrations, neither the unmodified nor the SOS2/SOS3-activated SOS1 protein showed K+ transport capacity in vivo, suggesting that the role of SOS1 on K+ uptake is indirect. Our results provide an example of functional reconstitution of a plant response pathway in a heterologous system and demonstrate that the SOS1 ion transporter, the SOS2 protein kinase, and its associated Ca2+ sensor SOS3 constitute a functional module. We propose a model in which SOS3 activates and directs SOS2 to the plasma membrane for the stimulatory phosphorylation of the Na+ transporter SOS1.
Reciprocal zones of excitation and inhibition in the neostriatum

Single‐unit activity was recorded in the rat neostriatum at different distances from the point of an infusion of either glutamate or serotonin. In each case, firing rate at the distant site (0.8–1.5 mm) was the mirror image of that at the near site (0.1–0.3 mm). These reciprocal changes were blocked by a subsequent injection of haloperidol, a dopamine antagonist. It appears that a lateral inhibitory network, intrinsic to the neostriatum and possibly modulated by dopamine, plays an important role in the operation of the neostriatum.
Development of questionnaires to measure psychosocial influences on children's physical activity.

BACKGROUND The purpose of this study was to develop and validate questionnaires used to measure psychosocial determinants of physical activity in preadolescent children. METHODS Three theory-based questionnaires and a measure of after-school physical activity were administered to 422 fifth-grade students. A cross-validation design was employed for psychometric development of the scales, including factor analysis, reliability, and validation by correlating scale scores with intention to be physically active and after-school physical activity. RESULTS The Social Influences scale contained a single factor. The Self-Efficacy scale contained three factors: support seeking, barriers, and positive alternatives. The Beliefs scale contained two factors: social outcomes and physical activity outcomes. Reliability coefficients ranged from about 0.50 to 0.78. Significant correlations were obtained between all six scales and intention in the development sample, and between five scales and intention in the validation sample. Significant correlations were obtained between social influence and self-efficacy barriers and physical activity in the development sample, and between social influences and physical activity in the validation sample. CONCLUSIONS Three scales to measure psychosocial determinants of physical activity were refined for use with rural, predominantly African-American, preadolescent children, and shown to be both reliable and valid. Factor analysis resulted in interpretable subscales that may be used as variables. These preliminary results provide support for using the scales to measure influences on activity in children.
Mathematical model of a virus-neutralizing immunglobulin response.

We present a mathematical model to simulate the kinetics of B-cell activation and the virus-neutralizing immunoglobulin response in the spleen of mice after infection with vesicular stomatitis virus (VSV). Our model combines data from in vitro experiments and in vivo kinetic observations. A system of eight nonlinear differential equations was used in the computer experiments and numerically solved. The isotype switch from IgM to IgG in the presence of T-cell help was modelled by a time variable function, used as a parameter. The model solutions indicate fast kinetics of the generation of VSV-neutralizing IgM antibodies within 2-3 days post immunization peaking on day 5 at a serum concentration of approximately 80 microgram ml-1 IgM, which is the equivalent to about 10% of the total IgM serum concentration. The frequency of virus-specific B cells increases about 1000-fold within the first 4 days after immunization. Protective levels of VSV-neutralizing IgG antibodies (>/=10 microgram ml-1) are reached within 5 to 6 days post immunization. Fitting the model solution to the experimentally observed neutralizing serum titers suggests an increase in the neutralizing activity of IgGs occurring between days 5 and 8 post-infection. The model indicates that less than 10 VSV-specific B cells have to be triggered daily to maintain protective IgG serum titers during the memory phase.
Body composition during weight loss in obese patients estimated by dual energy X-ray absorptiometry and by total body potassium.

OBJECTIVE To validate the ability of DXA to measure total body composition before and after weight loss and the composition of the lost body mass. DESIGN Cross sectional and follow-up study of body composition before and after a weight loss of 10.6 +/- 6.8 kg. SUBJECTS 31 obese subjects with a mean body weight of 105.2 +/- 15.2 kg at baseline, and a mean body weight of 94.6 +/- 16.5 kg at follow-up. MEASUREMENTS Body composition was measured by dual X-ray absorptiometry, total body potassium counting, and high precision scales before and after a weight loss. RESULTS DXA and the scales showed a strong linear relation (r = 1). At baseline, however, DXA underestimated the body weight by a maximum of 3.2 kg because the subjects were too large for the scan table. After weight loss body weight measurements were accurate. Before and after weight loss the linear relations between DXA and TBK for FFM were strong (r = 0.92 and 0.93). Bland and Altman plots showed limits of agreement of +/-9 kg before and after weight loss; DXA underestimated FFM in women and overestimated FFM in men. DXA accounted for 80% of the lost body weight. The composition of the lost body mass did not differ from that estimated by TBK (7.6% FFM and 92.4% FM by TBK; 11% FFM and 89% FM by DXA). CONCLUSION DXA estimates accurately the body composition and the composition of weight loss in groups of obese subjects. However, the scan table may be too small for patients weighing more than 95 kg.
On the near-wall characteristics of acceleration in turbulence

The behaviour of fluid-particle acceleration in near-wall turbulent flows is investigated in numerically simulated turbulent channel flows at low to moderate Reynolds numbers, Reτ = 180~600). The acceleration is decomposed into pressure-gradient (irrotational) and viscous contributions (solenoidal acceleration) and the statistics of each component are analysed. In near-wall turbulent flows, the probability density function of acceleration is strongly dependent on the distance from the wall. Unexpectedly, the intermittency of acceleration is strongest in the viscous sublayer, where the acceleration flatness factor of O(100) is observed. It is shown that the centripetal acceleration around coherent vortical structures is an important source of the acceleration intermittency. We found sheet-like structures of strong solenoidal accelerations near the wall, which are associated with the background shear modified by the interaction between a streamwise vortex and the wall. We found that the acceleration Kolmogorov constant is a linear function of y+ in the log layer. The Reynolds number dependence of the acceleration statistics is investigated.
MoS 2 Nanoribbons : High Stability and Unusual Electronic and Magnetic Properties

First-principles computations were carried out to predict the stability and magnetic and electronic properties of MoS2 nanoribbons with either zigzagor armchair-terminated edges. Zigzag nanoribbons show the ferromagnetic and metallic behavior, irrespective of the ribbon width and thickness. Armchair nanoribbons are nonmagnetic and semiconducting, and the band gaps converge to a constant value of ∼0.56 eV as the ribbon width increases. The higher stability of MoS2 nanoribbons, compared with the experimentally available triangular MoS2 nanoclusters, invites the experimental realization of such novel ribbons in true nanoscale.
Cognitive Trajectories in 4 Patients With Pediatric-Onset Multiple Sclerosis

Cognitive dysfunction is common in pediatric-onset multiple sclerosis, but long-term data on cognitive maturation in these patients are sparse. We report the clinical features and cognitive trajectories in 4 pediatric-onset multiple sclerosis patients who were 10 years or younger at first attack and were followed between 1998 and 2010. Relapses in all 4 patients were frequent early in the disease and became infrequent or absent over time. Declines on neuropsychological testing were most pronounced on measures of processing speed, specifically visuomotor speed, and executive control requiring mental sequencing and set shifting, whereas global intellectual ability and phonemic fluency remained stable or improved over time. These case studies demonstrate a negative impact of multiple sclerosis on cognitive development in the long term and suggest that continued observation into adulthood is required to appreciate the vocational consequences of pediatric-onset multiple sclerosis.
Soluble CD30 and ELISA‐detected human leukocyte antigen antibodies for the prediction of acute rejection in pediatric renal transplant recipients

Biomarker‐based post‐transplant immune monitoring for the prediction of impending graft rejection requires validation in specific patient populations. Serum of 28 pediatric renal transplant recipients within the framework of a well‐controlled prospective randomized trial was analyzed pre‐ and post‐transplant for soluble CD30 (sCD30), a biomarker reflecting mainly T‐cell reactivity, and anti‐human leukocyte antigen (anti‐HLA) antibody reactivity, a biomarker for B‐cell activation. A sCD30 concentration ≥40.3 U/ml on day 14 was able to discriminate between patients with or without biopsy‐proven acute rejection (BPAR) with a sensitivity of 100% and a specificity of 76%. Six of seven patients (86%) with BPAR showed a sCD30 above this cut‐off, whereas only 3/21 patients (14%) without BPAR had a sCD30 above this cut‐off (P = 0.004). For pre‐ and post‐transplant anti‐HLA class II reactivities by enzyme‐linked immunosorbent assay, a cut‐off value of 140 optical density was able to discriminate rejecters from nonrejecters with a sensitivity of 86% or 71% and a specificity of 81% or 90%, respectively. Withdrawal of steroids was associated with a approximately twofold higher serum sCD30 compared to controls, but did not affect anti‐HLA reactivities. An increased post‐transplant sCD30 serum concentration and positive pre‐ and post‐transplant anti‐HLA class II reactivities are informative biomarkers for impending BPAR in pediatric renal transplant recipients. (TWIST, Clinical Trial No: FG‐506‐02‐43)
The attitudes and beliefs of healthcare professionals on the causes and reporting of medication errors in a UK Intensive care unit

Our aim was to explore the attitudes and beliefs of healthcare professionals relating to the causes and reporting of medication errors in a UK intensive care unit. Medication errors were identified by the unit pharmacist and semi‐structured qualitative interviews conducted with 13 members of staff involved with 12 errors. Interviews were analysed using a model of human error theory. Staff identified many contributing factors, including poor communication and frequent interruptions. Organisational factors included lack of clarity on the responsibility of the second nurse's check for medication administration, lack of feedback on medication errors, and a common and accepted practice of administering medication without a complete medication order. Barriers to reporting included administrative paperwork and lack of encouragement by management. Greater feedback on medication errors seems essential to improve current practice and increase reporting.
Shear Wave Elastography of Focal Liver Lesion: Intraobserver Reproducibility and Elasticity Characterization

Purpose The aim of the study was to evaluate the intraobserver reproducibility and to determine the elasticity characteristics of focal liver lesions (FLLs) by shear wave elastography (SWE). Methods One hundred thirty-six FLLs in 118 patients were examined with SWE for quantitative and qualitative assessment of stiffness. Three SWE images were obtained for each lesion and liver parenchyma by 1 radiologist. Intraobserver reproducibility was assessed by intraclass correlation coefficients (ICCs). Patient and lesion factors that can affect the reproducibility were evaluated. For characterization of the lesion elasticity, the difference in stiffness between the groups of lesions was evaluated. Results The mean (SD) diameter and depth of the lesions were 3.98 (2.07) and 4.4 (1.59) cm, respectively. The ICC of intraobserver reproducibility was 0.763. Deep-seated lesions (≥6 cm; ICC, 0.621) showed significantly lower intraobserver reproducibility compared with superficial lesions (ICC, 0.793; P = 0.047). Stiffness values of malignant lesions (n = 85, 60.41 [47.81] kPa) were significantly higher than those of benign lesions (n = 51, 22.05 [17.24] kPa, P < 0.0001). Mean (SD) stiffness of hepatocellular carcinoma (45.72 [35.65] kPa) was significantly lower than that of metastasis (67.43 [43.39] kPa) and was significantly higher than benign FLLs (22.05 [17.24] kPa). However, mean (SD) lesion-parenchyma ratio of hepatocellular carcinoma (3.76 [4]) was not significantly different from that of benign FLLs (3.7 [3.77]). Conclusions Overall, intraobserver reproducibility of SWE in evaluation of FLLs was excellent, but it can be affected by lesion depth. In addition, SWE is helpful in elasticity characterization of FLLs.
Resilience to seasonal heat wave episodes in a Mediterranean pine forest.

Short-term, intense heat waves (hamsins) are common in the eastern Mediterranean region and provide an opportunity to study the resilience of forests to such events that are predicted to increase in frequency and intensity. The response of a 50-yr-old Aleppo pine (Pinus halepensis) forest to hamsin events lasting 1-7 d was studied using 10 yr of eddy covariance and sap flow measurements. The highest frequency of heat waves was c. four per month, coinciding with the peak productivity period (March-April). During these events, net ecosystem carbon exchange (NEE) and canopy conductance (gc ) decreased by c. 60%, but evapotranspiration (ET) showed little change. Fast recovery was also observed with fluxes reaching pre-stress values within a day following the event. NEE and gc showed a strong response to vapor pressure deficit that weakened as soil moisture decreased, while sap flow was primarily responding to changes in soil moisture. On an annual scale, heat waves reduced NEE and gross primary productivity by c. 15% and 4%, respectively. Forest resilience to short-term extreme events such as heat waves is probably a key to its survival and must be accounted for to better predict the increasing impact on productivity and survival of such events in future climates.
[Long-term efficacy of dapagliflozin in patients with type 2 diabetes mellitus receiving high doses of insulin].

BACKGROUND Dapagliflozin, a selective inhibitor of sodium-glucose cotransporter 2, may improve glycemic control with a lower dose of insulin and attenuate the associated weight gain in patients with inadequate control despite high doses of insulin. OBJECTIVE To evaluate the efficacy and safety of adding dapagliflozin therapy in patients whose type 2 diabetes mellitus is inadequately controlled with insulin with or without oral antidiabetic drugs. DESIGN A 24-week, randomized, placebo-controlled, multicenter trial followed by a 24-week extension period. An additional 56-week extension period is ongoing. (ClinicalTrials.gov registration number: NCT00673231). SETTING 126 centers in Europe and North America from 30 April 2008 to 19 November 2009. PATIENTS 808 patients with inadequately controlled type 2 diabetes mellitus receiving at least 30 U of insulin daily, with or without up to 2 oral antidiabetic drugs. INTERVENTION Patients were randomly assigned in a 1:1:1:1 ratio and allocated with a computer-generated scheme to receive placebo or 2.5, 5, or 10 mg of dapagliflozin, once daily, for 48 weeks. MEASUREMENTS The primary outcome was change in hemoglobin A1c from baseline to 24 weeks. Secondary outcomes included changes in body weight, insulin dose, and fasting plasma glucose level at 24 weeks and during the 24-week extension period. Adverse events were evaluated throughout both 24-week periods. RESULTS 800 patients were analyzed. After 24 weeks, mean hemoglobin A1c decreased by 0.79 % to 0.96 % with dapagliflozin compared with 0.39 % with placebo (mean difference, -0.40 % [95 % CI, -0.54 % to -0.25 %] in the 2.5-mg group, -0.49 % [CI, -0.65 % to -0.34 %] in the 5-mg group, and -0.57 % [CI, -0.72 % to -0.42 %] in the 10-mg group). Daily insulin dose decreased by 0.63 to 1.95 U with dapagliflozin and increased by 5.65 U with placebo (mean difference, -7.60 U [CI, -10.32 to -4.87 U] in the 2.5-mg group, -6.28 U [CI, -8.99 to -3.58 U] in the 5-mg group, and -6.82 U [CI, -9.56 to -4.09 U] in the 10-mg group). Body weight decreased by 0.92 to 1.61 kg with dapagliflozin and increased by 0.43 kg with placebo (mean differences, -1.35 kg [CI, -1.90 to -0.80 kg] in the 2.5-mg group, -1.42 kg [CI, -1.97 to -0.88 kg] in the 5-mg group, and -2.04 kg [CI, -2.59 to -1.48 kg] in the 10-mg group). These effects were maintained at 48 weeks. Compared with the placebo group, patients in the pooled dapagliflozin groups had a higher rate of hypoglycemic episodes (56.6 % vs. 51.8 %), events suggesting genital infection (9.0 % vs. 2.5 %), and events suggesting urinary tract infection (9.7 % vs. 5.1 %). LIMITATION Insulin doses were not titrated to target, and the study was not designed to evaluate long-term safety. CONCLUSION Dapagliflozin improves glycemic control, stabilizes insulin dosing, and reduces weight without increasing major hypoglycemic episodes in patients with inadequately controlled type 2 diabetes mellitus.
Leukocytic Invasion of the Ovine Cervix at Parturition

Objective: The aim of this study was to use the activity of a leukocyte-specific enzyme, myeloperoxidase, to quantify changes in leukocyte concentration in the ovine cervix during pregnancy. Methods: Cervical tissue was collected under halothane general anesthesia from 26 sheep at different stages of gestation, in the nonpregnant state, and postpartum. Myeloperoxidase activity was used to assess the degree of leukocytic infltration of the tissue. Results: Myeloperoxidase activity was low in cervices from nonpregnant ewes and did not increase during pregnancy until the onset of labor. Myeloperoxidase activity decreased after parturition. Conclusion: Labor in sheep is associated with leukocytic invasion of the cervix. This observation suggests that leukocytes could participate in cervical connective-tissue reorganization during dilatation at parturition and in postpartum involution of the cervic in this species.
Feedforward linearisation applied to a direct carrier modulation transmitter

A feedforward system for direct carrier modulation transmitters is proposed and experimental results are presented. The advantage of this architecture over the conventional one using a feedforward amplifier is that the overall distortion resulting from the modulator is also reduced. The feedforward structure needs a reference signal to compare and cancel distortions: this is achieved using a second modulator which is operated at very low input level to obtain a signal with a negligible distortion. Simulation results suggest that the effect of LO feedthrough which can deteriorate the signal quality is also reduced. Experimental results on a 900 MHz feedforward transmitter with 192 kbps BPSK modulation and Nyquist filtering (/spl alpha/=0.35) show that adjacent channel interference is reduced by as much as 30 dB.
LSD IN PSYCHOTHERAPY.

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Do Older Investors Make Better Investment Decisions?

Abstract This paper examines the investment decisions of older individual investors. We find that older and experienced investors are more likely to follow rules of thumb that reflect greater investment knowledge. However, older investors are less effective in applying their investment knowledge and exhibit worse investment skill, especially if they are less educated, earn lower income, and belong to minority racial/ethnic groups. Overall, the adverse effects of aging dominate the positive effects of experience. These results indicate that older investors' portfolio decisions reflect greater knowledge about investing, but investment skill deteriorates with age due to the adverse effects of cognitive aging.