Miracle-dz/UniFAR-FTUs huggingface dataset:
Performance of a side-mounted PIFA in cluttered environment for GPS operation

Performance of the GPS mobile terminal antennas is severely affected by the surrounding environment. The incident radio waves experience reflection, diffraction and scattering due to the presence of vehicles, buildings, trees and ground plane (earth) near to the receiving GPS antenna. A statistical model has been proposed by Ur Rehman et al. [8], [9] to evaluate and characterise the environmental factors on the GPS mobile terminal antennas. This method needs the information of 3-D free space antenna gain patterns and average angular distribution of incident power in the environment. This technique assesses the performance of the GPS antenna in terms of two novel parameters namely GPS Mean Effective Gain (MEGGPS) and GPS Coverage Efficiency (ηc). This paper presents a novel design of the GPS mobile terminal PIFA antenna. The antenna is fabricated and tested in anechoic chamber for free space operation. The performance of the proposed antenna is also investigated in GPS multipath environment using the statistical approach. Usefulness of this antenna is analysed by comparing its performance to that of the dipole and CP microstrip patch antennas reported in [9].
Radiofrequency ablation of hepatic tumors adjacent to the gallbladder: feasibility and safety.

OBJECTIVE This study was performed to assess the feasibility and safety of radiofrequency ablation of hepatic tumors adjacent to the gallbladder. MATERIALS AND METHODS Of the 83 patients who underwent radiofrequency ablation of hepatic tumors at our institution between December 1997 and August 2000, we identified eight patients--four men and four women who were 42-85 years old (mean age, 67 years)--who had tumors adjacent to the gallbladder. All ablations were performed with curative intent. We reviewed the patients' preablation imaging, radiofrequency ablation parameters, and course after ablation. Follow-up ranged from 3 to 22 months (mean, 8 months). RESULTS Six patients with colorectal carcinoma and two with hepatocellular carcinoma had a total of 14 tumors adjacent to the gallbladder. Of the 14 tumors, nine (64%) were metastases and five (36%) were hepatocellular carcinoma. Eleven tumors (79%) were located directly adjacent to the gallbladder and three (21%) were located within 1 cm of the gallbladder. Tumor size ranged from 0.9 to 4.5 cm (mean, 3.6 cm). The number of radiofrequency ablations performed on each tumor ranged between one and six (mean, three ablations). Right upper quadrant pain developed in the immediate postablation period (within 7 days after the ablation) in six patients (75%) and ranged in duration from 5 to 21 days (mean, 7 days). Fever developed in four patients (50%), with a mean duration of 5 days. Arthralgia and right shoulder pain developed in one patient (12%). No deaths were noted in the immediate period after ablation. Complete ablation of all tumors visible on CT was achieved in seven patients. Of these, one patient (14%) had local tumor recurrence after 11 months. CONCLUSION Radiofrequency ablation of tumors adjacent to the gallbladder is feasible and appears to be safe. Self-limited morbidity after ablation is noted in most patients and is probably related to a mild iatrogenic cholecystitis.
Effect of treatment with simvastatin on serum cholesteryl ester transfer in patients on dialysis. PERFECT Study Collaborative Group.

BACKGROUND Plasma cholesteryl ester transfer activity is increased in patients with chronic renal failure on dialysis who have elevated levels of apolipoprotein B (apoB)-containing lipoproteins. Simvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitor, reduces levels of these lipoproteins but the effect of treatment on cholesteryl ester transfer activity in patients on dialysis remains to be determined. METHODS We measured serum newly synthesized cholesteryl ester transfer (NCET) activity, lecithin:cholesterol acyltransferase (LCAT) activity and serum lipid, lipoprotein and apolipoprotein concentrations before and immediately after 6 months treatment with simvastatin (10 mg daily, n = 24) or placebo (n = 29) in 53 patients with chronic renal failure receiving haemodialysis or continuous ambulatory peritoneal dialysis (CAPD). RESULTS Simvastatin therapy significantly reduced serum cholesterol, LDL cholesterol, apoB concentrations, and both NCET (P = 0.001) and LCAT (P = 0.012) rates. The decrease in NCET activity was correlated significantly with the corresponding decrease in apoB concentration (r = 0.715, P < 0.001) and LCAT activity (r = 0.715, P < 0.001) during simvastatin therapy and was no longer significant when apoB concentration (P = 0.14) or LCAT activity (P = 0.07) were controlled. CONCLUSIONS These data show that simvastatin therapy reduces serum NCET rates, and suggest that this may be linked to the concomitant decrease in levels of apoB-containing lipoproteins which are acceptors of transferred cholesteryl esters, and to the decrease in serum LCAT rates in patients with chronic renal failure with treatment.
Social Media and Politics in Indonesia

Does social media have the potential to influence the political process more in certain countries? How do political actors and citizens use social media to participate in the political process? This paper analyzes these questions in the context of contemporary Indonesia, a country with a young democracy and a vibrant emerging economy. First, the relationships between traditional and social media and politics are discussed. Then, the current situation in Indonesia’s traditional media industry and how it may have helped drive the popularity of social media in Indonesia is analyzed. Finally, the paper discusses social media in today’s Indonesia and provides examples of how political actors and citizens use social media in the political process.
Direct relationship between radiobiological hypoxia in tumors and monoclonal antibody detection of EF5 cellular adducts

While the potential importance of hypoxia in limiting the sensitivity of tumor cells to ionizing radiation has long been appreciated, methods for accurately quantifying the number of radiation‐resistant hypoxic cells within tumors have been lacking. We have used the pentafluorinated derivative [2‐(2‐nitro‐IH‐imidazol‐l‐yl)‐N‐(2,2,3,3,3‐pentafluoropropyl)‐acetamide] of etanidazole (EF5), which binds selectively to hypoxic cells. The adducts formed between EF5 and cellular proteins in the hypoxic cells were detected using the specific monoclonal antibody (MAb), ELK3‐51 conjugated to the flurochrome Cy3, and the number of hypoxic cells was quantified by flow cytometry. To verify the validity of this technique for the detection of hypoxic cells, mice bearing KHT sarcomas were treated with various agents to alter tumor oxygenation and hence vary the fraction of radiobiologically hypoxic tumor cells. The percentage of EF5 binding cells was then compared directly with the clonogenic survival of the tumor cells following radiation treatment under the various pretreatment conditions. The results showed that allowing the mice to breathe carbogen (5% CO2/95% O2) prior to irradiation reduced clonogenic cell survival approx. 6‐fold and led to an absence of cells binding high levels of EF5. In contrast, pretreating the tumor‐bearing animals with either hydralazine, which decreased tumor blood flow, or phenylhydrazine hydrochloride, which made the mice anemic, increased tumor cell survival following irradiation 2‐ to 4‐fold, indicative of an increase in the fraction of hypoxic tumor cells. EF5 measurements made under identical conditions illustrated a shift in the cells in the tumor to high EF5 binding. Our results demonstrate that flow cytometric measurement by fluorescent MAb binding to EF5 adducts may relate directly to radiobiological hypoxia in KHT tumors measured by conventional methods. © 1996 Wiley‐Liss, Inc.
Regional anesthesia and analgesia in cancer care: is it time to break the bad news?

Purpose of review There is ongoing controversy regarding the tumor-protective effects of regional anesthesia in patients undergoing cancer surgery. Evidence of up-to-date systematic reviews will be presented alongside recent updates on the effects of opioids and local anesthetics. Recent findings In recent years, the literature regarding the effects of regional anesthesia techniques on cancer recurrence has raised many unanswered questions. Ongoing randomized controlled trials may not be able to shed light on the controversial discussion regarding the tumor protective effects of regional anesthesia because the expected effect size and event rate in those studies may be overstated. Recent more refined animal data, provides no evidence to suggest that opioids promote cancer recurrence or facilitate the development of metastatic disease. In addition, local anesthetics have promising preclinical anticarcinogenic effects that extend beyond their voltage-gated sodium channel blocking properties and could be of therapeutic value. Summary Cancer recurrence in patients undergoing surgery remains a global burden. Current evidence suggests that regional techniques, opioid analgesia and local anesthetics in onco-anesthesia may require a tailored individual approach due to the phenotypic and genotypic heterogeneity within and between different tumors. The authors surmise that future or ongoing randomized controlled trials regarding regional anesthesia techniques and cancer outcome may not be able to reproduce clear results, as it will be challenging to prove the efficacy of one single intervention (e.g. regional anesthesia) in an otherwise complex multifactorial perioperative oncological setting.
Credit Constraints, Export Mode and Firm Performance: An Investigation of China's Private Enterprises

Firms can export either directly or through a trade intermediary (indirect exporting). This paper examines how financial constraints determine whether firms export directly or indirectly, and how this choice affects firm performance. For this investigation, we use the most recent Chinese private firm-level data, collected in 2011 by the World Bank. We establish two main results. First, indirect exporters face higher financial constraints than direct exporters. Second, indirect exporters are less productive and profitable than direct exporters. In addition, we rationalize these patterns with a simple model that incorporates credit constraints and imperfect contractibility in companies’ export decisions. Our results imply that although globalization allows more firms in developing countries to enter the global market through indirect exporting, limited access to capital restricts firms to exporting directly and precludes them from pursuing more profitable opportunities.
Mechanisms underlying the renoprotective effect of GABA against ischaemia/reperfusion‐induced renal injury in rats

Excitation of the renal sympathetic nervous system is important for the development of ischaemic acute kidney injury (AKI) in rats. We reported that intravenous treatment with GABA has preventive effects against ischaemia/reperfusion (I/R)‐induced renal dysfunction with histological damage in rats; however, the mechanisms underlying these effects on renal injury remain unknown. Thus, the aim of the present study was to clarify how GABA mechanistically affects ischaemic AKI in rats. Ischaemic AKI was induced in rats by clamping the left renal artery and vein for 45 min and then reperfusing the kidney to produce I/R‐induced injury. Treatment with the GABAB receptor antagonist CGP52432 (100 nmol/kg, i.v., or 1 nmol/kg, i.c.v.) abolished the suppressive effects of 50 μmol/kg, i.v. , GABA on enhanced renal sympathetic nerve activity (RSNA) during ischaemia, leading to elimination of the renoprotective effects of GABA. Intracerebroventricular treatment with 0.5 μmol/kg GABA or i.v. treatment with 1 μmol/kg baclofen, a selective GABAB receptor agonist, prevented the I/R‐induced renal injury equivalent to i.v. treatment with GABA. Conversely, i.v. treatment with 10 μmol/kg bicuculline, a GABAA receptor antagonist, failed to affect the preventive effects of GABA against ischaemic AKI. We therefore concluded that GABAB receptor stimulation in the central nervous system, rather than peripheral GABAB receptor stimulation, mediates the preventive effect of GABA against ischaemic AKI by suppressing the enhanced RSNA induced by renal ischaemia.
Social Screens and Systematic Investor Boycott Risk

We model the pricing implications of screens adopted by socially responsible investors. The model reproduces the empirically observed abnormal return to sin stock and implies a premium for systematic investor boycott risk that affects targeted as well as nontargeted firms. The investor boycott premium is not displaced by litigation risk, measures of neglect effect, illiquidity, industry momentum, or concentration. The investor boycott risk factor is useful in explaining mean returns across industries, and its premium varies with the relative wealth of socially responsible investors and the business cycle.
Military experience and corporate tax avoidance

We find that managers with military experience pursue less tax avoidance than other managers and pay an estimated $1–$2 million more in corporate taxes per firm-year. These managers also undertake less aggressive tax planning strategies with smaller tax reserves and fewer tax havens. Although they leave tax money on the table, boards hiring these managers benefit from reductions in other gray areas in corporate reporting. The broad implications are as follows: for employee selection, boards can consider employees’ personal characteristics as a control mechanism when outputs are difficult to contract ex ante or measure ex post.
Gender Behind-the-Scenes: Women's Career Experiences in the Contemporary US Film and Television Industry

Since the 1980s the film and television industry in the United States has developed into a largely contract-based system characterised by career insecurity and precarity. Based upon 27 semi-structured in-depth interviews conducted in Los Angeles, San Francisco, and Chicago during the summer of 2013, I analysed women’s reported career experiences in the contemporary US film and television industry. Using Banks’ (2009) concept of feminist production studies, which integrates political economy, cultural studies, and gendered perspectives I focused on several key areas of women’s careers as reported by my participants for analysis. I divided my analysis into three parts based upon data gathered through the interviews. First I explore how and why my participants chose to enter work in an industry characterised by precarious employment and then why, despite this insecurity, they chose to continue working in this field. Next, I analyse women’s networking practices in film and television work, how they conceptualised these relationships, and argue that my participants’ networking practices are embodied, genuine, selective, and managed contradicting some elements of Wittel’s (2001) concept of ‘network sociality. ’ I conclude with an examination of women’s reported experiences of sexism and discrimination in the contemporary industry and strategies my participants used to avoid such encounters. Research concerning labour in the cultural industries has become more prevalent since the 1990s. However, most of this work has been conducted in reference to cultural work/ers in the UK and Europe. This thesis illuminates the career experiences of women of varied ages who work in diverse occupations in the contemporary US film and television industry.
Characterization of Promoter Function and Cell-Type-Specific Expression from Viral Vectors in the Nervous System

ABSTRACT Viral vectors have become important tools to effectively transfer genes into terminally differentiated cells, including neurons. However, the rational for selection of the promoter for use in viral vectors remains poorly understood. Comparison of promoters has been complicated by the use of different viral backgrounds, transgenes, and target tissues. Adenoviral vectors were constructed in the same vector background to directly compare three viral promoters, the human cytomegalovirus (CMV) immediate-early promoter, the Rous sarcoma virus (RSV) long terminal repeat, and the adenoviral E1A promoter, driving expression of the Escherichia coli lacZ gene or the gene for the enhanced green fluorescent protein. The temporal patterns, levels of expression, and cytotoxicity from the vectors were analyzed. In sensory neuronal cultures, the CMV promoter produced the highest levels of expression, the RSV promoter produced lower levels, and the E1A promoter produced limited expression. There was no evidence of cytotoxicity produced by the viral vectors. In vivo analyses following stereotaxic injection of the vector into the rat hippocampus demonstrated differences in the cell-type-specific expression from the CMV promoter versus the RSV promoter. In acutely prepared hippocampal brain slices, marked differences in the cell type specificity of expression from the promoters were confirmed. The CMV promoter produced expression in hilar regions and pyramidal neurons, with minimal expression in the dentate gyrus. The RSV promoter produced expression in dentate gyrus neurons. These results demonstrate that the selection of the promoter is critical for the success of the viral vector to express a transgene in specific cell types.
Serum Insulin-Like Growth Factors and Insulin-Like Growth Factor Binding Proteins in the Human Fetus. Relationships with Growth in Normal Subjects and in Subjects with Intrauterine Growth Retardation

ABSTRACT: IGF-I, IGF-II, and their binding proteins (BP) were studied in sera obtained by direct puncture of umbilical cords in utero between 20 and 37 wk of gestation in 103 normal fetuses and in 16 fetuses with intrauterine growth retardation, as well as in the cord blood of 37 normal newborns of 38− to 42-wk pregnancies. In normal fetuses, IGF-I levels were approximately 50 ng/mL and IGF-II levels approximately 350 ng/mL up to the 33rd wk of pregnancy. Thereafter, both increased to reach values two to three times higher at term. Correlations were found between fetal placental lactogen levels and those of IGF-I and IGF-II, which is consistent with the hypothesis that placental lactogen is involved in the regulation of IGF synthesis in the fetus. With weight (either measured at birth or deduced from echographical data) as index of fetal size, IGF-I levels were significantly (p < 0.001) higher in fetuses with weights above the mean for gestational age than in fetuses with weights below the mean, whereas IGF-II levels were similar in the two groups. Similarly, IGF-I (but not IGF-II) levels in fetuses with intrauterine growth retardation were significantly lower than those in normal fetuses of the same age (p < 0.01). These findings suggest that, during the latter months of intrauterine life, IGF-I (but not IGF-II) is involved in the control of fetal size. Total fetal BP concentrations were approximately 1/3 those of adults. The fetal electrophoretic profile obtained by Western-ligand blotting bore a strong resemblance to that of subjects with growth hormone deficiency. In new borns, the proportions of IGF-I and IGF-II associated with BP to form 150-kD complexes were considerably lower than those in adults, but similar to those in hypopituitary patients. It may be deduced from these findings that during fetal life, BP synthesis is adapted to increase the bioavailability of the IGF at a time when growth is at a maximum.
Differential Effects of Buy and Sell Rules in Sentiment-Informed EUR/USD Trading

Sentiment indicators are often appealing to investors since financial markets are known to be influenced not only by economic fundamentals but also by emotions (Shiller & Akerlof, 2009). In current studies, however, a range of alternative sentiment indices is used each of which purports to have predictive value for the movements in financial markets. Consequently, a question mark remains in regards to the comparability of findings across different research papers. The goal of this study is to address the question of choice between competing sentiment indicators in EUR/USD trading. To identify the indicator having the best predictive value we estimate expected returns for individual sources and forecast models via backtesting (Campbell, 2005). Our findings support the notion that the predictive value depends on the source of the sentiment-indicator, on timing aspects, with more recent sentiments having greater predictive strength, and on the type of rule (e.g., buy/sell) harnessed.
Vitamins C and e reduce retinal oxidative stress and nitric oxide metabolites and prevent ultrastructural alterations in porcine hypercholesterolemia.

PURPOSE Oxidative stress is thought to be involved in the pathogenesis of age-related diseases, such as atherosclerosis and retinal degeneration. The current study was conducted to examine vitreoretinal oxidative status in a model of porcine hypercholesterolemia to identify morphologic alterations and analyze the effect of dietary supplementation with vitamins C and E. METHODS Adult miniature pigs were fed standard chow, cholesterol-rich chow, or a cholesterol-rich diet supplemented with vitamins C and E. Total cholesterol, triglycerides, high-density lipoproteins, lipid peroxidation, and tocopherol were measured in plasma. Lipid peroxidation and nitric oxide (NO) metabolites were measured in vitreous and retinal homogenates. Superoxide anion release in the retinal pigment epithelium (RPE) was analyzed by chemiluminescence. Retinal morphology was studied by transmission electron microscopy. RESULTS The high-cholesterol group, with increased retinal oxidative stress (P < 0.01) and NO metabolites in the retina (P < 0.05), had increased superoxide anion release (P < 0.05) and showed development of pyknosis, irregular nuclear membranes, and cytoplasmic accumulation of lipids and autophagocytic vacuoles in the RPE cells. Vitamins C and E prevented biochemical changes and most ultrastructural alterations in the RPE. CONCLUSIONS The results suggest an evolving role for hypercholesterolemia through increased retinal oxidative stress and NO synthesis that could be responsible for retinal ultrastructural alterations. The beneficial effects of vitamins C and E in the retinal tissue further support this hypothesis.
Quotidian High Spiking Fevers in Adult Still’s Disease

Patient: Female, 29 Final Diagnosis: Adult Still’s Disease Symptoms: Fever • arthralgia • sore throat • shortness of breath Medication: — Clinical Procedure: — Specialty: Rheumatology Objective: Rare disease Background: Adult Still’s disease (ASD) is a rare systemic inflammatory condition, which commonly presents with the triad of quotidian fevers, rash, and non-specific rheumatologic symptoms such as myalgia and arthralgia. The etiology and pathogenesis are poorly understood and both the clinical presentation and laboratory data are typically nonspecific. As such, the presentation is often confused with infection, other autoimmune processes, and malignancy. Case Report: We present a case of a 29-year-old Hispanic female who presented with fever, sore throat, myalgia, and shortness of breath. Initially diagnosed with suspected pneumonia, extensive workup led to the final diagnosis of ASD due to the persistence of her symptoms, which met Yamaguchi Criteria, as well as exclusion of other possible etiologies. Conclusions: ASD is a rare systemic inflammatory condition and its nonspecific presentation often leads to diagnostic delay and disease complications. We discuss the incidence, etiology, pathology, diagnosis, and standards in management of ASD. This case emphasizes the need for high clinical suspicion of ASD, and early exclusion of other etiologies, especially with failure of first-line treatment, to limit patient suffering and complications.