Miracle-dz/UniFAR-FTUs huggingface dataset:
Age at menarche and selected menstrual characteristics in athletes at different competitive levels and in different sports.

Ages at menarche in 110 non-athletes, 59 high school atjletes, 53 college athletes, and 18 olympic volleyball candidates were determined through interview. The athletes attained menarche significantly later than the non-athletes (p less than .001), and the olympic athletes attained menarche significantly later than the high school and college athletes (p less than .001). The high school and college athletes did not differ significantly in the mean age at menarche. When menarche in college athletes was analyzed by specific sports, the small samples of participants in golf (n = 4), volleyball (n = 7), swimming (n = 7), basketball (n = 16), and gymnastics and track (n = 6) did not differ significantly from each other in the mean age at menarche. The olympic volleyball aspirants attained menarche significantly later than all sport-specific groups (p less than .05 to p less than .001) except the gymnastics-track and tennis (n = 13) athletes. Smaller samples of non-athletes (n = 27) and college athletes (n = 21 from volleyball and basketball), plus the olympic athletes were also interviewed regarding selected menstrual characteristics. Although the athletes reported a greater incidence of dysmenorrhea and menstrual irregularity, none of the chi square values comparing the three groups was significant.
Expression of human thrombomodulin cofactor activity in porcine endothelial cells.

BACKGROUND Xenograft rejection may predispose to vascular thrombosis because of putative cross-species' functional incompatibilities between natural anticoagulants present on the donor endothelium and host activated coagulation factors. For example, porcine thrombomodulin expressed on porcine aortic endothelial cells (PAEC) does not provide the expected thrombomodulin (TM)-cofactor activity for human protein C in the presence of human thrombin. In addition, TM may be down-regulated after cellular activation. Our aim was to express human TM cofactor activity in PAEC and to study the proinflammatory effect of tumor necrosis factor-alpha (TNF-alpha) on stable expressed human thrombomodulin in vitro. METHODS AND RESULTS Retroviral transduction of PAEC with the gene encoding for human thrombomodulin (hTM) resulted in expression of high levels of specific TM cofactor activity on PAEC (0.62 microg/ml activated protein C/10(5) cells). High-level expression of hTM resulted in a 620-fold higher activation of human protein C in the presence of human thrombin when compared with mock-transduced PAEC (0.0001 microg/ml/10(5) cells; P<0.001). Transduced PAEC expressing hTM also bound more human thrombin than control PAEC, as determined by inhibition of thrombin-induced platelet activation (P<0.05). We noted that exposure to TNF-alpha significantly reduced exogenous hTM cofactor activity on transduced PAEC in a time- and dose-dependent fashion; this occurred despite the relatively stable expression of hTM mRNA and hTM antigen in these cells. Treatment of transduced PAEC with selected antioxidants could protect against the loss of hTM cofactor activity directly associated with the oxidative stress induced by TNF-alpha activation responses. CONCLUSIONS Our data show that the functional deficiency of the anticoagulant protein C pathway in PAEC may be corrected by viral transduction of these cells. As analysis of the hTM function showed modulation under conditions of cellular activation, we suggest that expression of hTM mutants resistant to oxidation may have greater therapeutic utility in the genetic modification of porcine xenografts.
ERROR-CORRECTION MODEL OF QUOTE PRICES *

In this paper we analyze and interpret the quote price dynamics of 100 NYSE stocks stratified by trade frequency. We specify an error-correction model for the log difference of the bid and the ask price with the spread acting as the error-correction term, and include as regressors the characteristics of the trades occurring between quote observations, if any. From this model we are also able to extract the implied model for the spread and the mid-quote. We find that short duration and medium volume trades have the largest impacts on quote prices for all one hundred stocks. Further, we find that buys have a greater impact on the ask price than on the bid price, while sells have a greater impact on the bid price than on the ask price. Both buys and sells increase spreads in the short run, but in the absence of further trades, the spreads mean revert. Trades have a greater impact on quotes for the infrequently traded stocks than for the more actively traded stocks.
Risk of cesarean delivery after induction at term in nulliparous women with an unfavorable cervix.

OBJECTIVE The purpose of this study was to evaluate the effect of induction on the route of delivery in nulliparous women laboring at term in a community hospital system. STUDY DESIGN From April 1997 to October 1999, there were 7282 deliveries in nulliparous patients who met inclusion criteria. Cesarean delivery rates were calculated for patients in spontaneous labor and for patients who underwent induction. RESULTS Among 4635 women (63.7%) in spontaneous labor, the cesarean delivery rate was 11.5% versus 23.7% among the 2647 (36.3%) patients who underwent induction. An important variable that affected the delivery route was the Bishop score at the initiation of the induction. The cesarean delivery rate was 31.5% among patients whose Bishop score was <5 at induction versus 18.1% for patients with a score > or =5(P <.001). CONCLUSION The induction of labor in nulliparous patients, especially those women with an unfavorable cervix as measured by Bishop score, is associated with a significantly increased risk of cesarean delivery.
An alternative classification of project delivery methods used in the United States building construction industry

Although many sources describe the project delivery methods available to owners, there is little empirical data on their defining characteristics. The objective of this research was to examine patterns in contract arrangements, procurement practices and compensation terms used in the US building construction industry. Survey data were collected for projects completed between 2008 and 2013 (N = 204) from owners and contractors belonging to large US professional organizations. A latent class analysis was used to identify five distinct patterns or ‘classes’ based upon eight characteristics of the project delivery process. These classes were defined as: (I) late builder and trade involvement, with an open, cost-based selection and lump sum contract (9% of projects in sample); (II) late builder and trade involvement, with a prequalified, cost-based selection and lump sum contract (19%); (III) early builder and late trade involvement, with a prequalified non-cost based selection and guaranteed maximum price (GMP) contract (26%); (IV) early builder and trade involvement, with a prequalified, cost-based selection and lump sum design-build (DB) contract (27%); (V) early builder and trade involvement, with a prequalified, non-cost based selection and GMP DB contract (18%). Compared to existing classifications of project delivery methods, these classes are data-driven typologies that represent how participants are procured and organized into a project team. The findings have implications as an alternative classification system in project delivery research and as guidance to owners considering their project delivery options.
[Study on ingredients of essential oils of Curcuma wenyujin extracted by supercritical-CO2 fluid extraction and steam distillation].

OBJECTIVE To compare the ingredients of essential oils of Curcuma wenyujin extracted by supercritical-CO2 fluid extraction and by steam distillation. METHOD GC-MS was applied in this experiment. RESULT The ingredients and physical and chemical properties of essential oils of C. wenyujin extracted by supercritical-CO2 fluid extraction and by steam distillation are similar. CONCLUSION Supercritical-CO2 fluid extraction is better than steam distillation in extraction time, power consumption, recovery and purity.
Complete mitochondrial genome of the acorn barnacle Striatobalanus amaryllis (Crustacea: Maxillopoda): the first representative from Archaeobalanidae

Abstract The mitochondrial genome of the barnacle Striatobalanus amaryllis (Sessilia: family Archaeobalanidae) is 15,063 bp in length. All the 13 protein-coding genes (PCGs) initiate with ATD codon (ATG, ATA or ATT). Four PCGs (COX3, ND3, ND4 and ND4L) end with incomplete stop codon (T- -). Four PCGs (ND1, ND4, ND4L and ND5) are encoded on the light strand (underlined below). Refer to the pancrustacean ground pattern, there are not less than seven tRNAs rearranged in the S. amaryllis mitochondrial genome, including tRNAAla, tRNAGlu/tRNASer(AGY), tRNAPro/tRNAThr, tRNAPro/tRNAThr, tRNATyr, tRNALys, tRNAGln and tRNACys. Three tRNAs (tRNALys, tRNAGln and tRNACys) are rearranged between S. amaryllis and Tetraclita japonica (Sessilia: Tetraclitidae), meanwhile one tRNA (tRNACys) inverted from one strand to another. Compared with Megabalanus volcano (Sessilia: Balanidae), an inversion of one large gene block is identified (including three PCGs and three tRNAs) in S. amaryllis mitochondrial genome: tRNAPhe-ND5-tRNAHis-ND4-ND4L-tRNAPro.
Real Effects of Tax Uncertainty: Evidence from Firm Capital Investments

This paper examines whether tax uncertainty can alter investment decisions, focusing primarily on the timing of large capital investments. Empirically, we exploit the staggered implementation of Schedule UTP, a discrete policy change expected to increase tax uncertainty, finding that, on average, firms responded by delaying large capital investments. This effect is stronger among firms at which the policy treatment is particularly germane, that is, for firms with more material UTBs or with low-to-moderate quality public accounting information. We also test the underlying mechanism, finding that managers buffer against higher tax uncertainty with cheaper sources of financing (cash) and that the investment effect is concentrated among financially constrained firms. The results show that Schedule UTP also reduces the sensitivity of investment to growth opportunities (investment-Q sensitivity) in line with a higher hurdle rate for firms facing higher tax uncertainty. This paper was accepted by Brian Bushee, accounting.
Identification of the border between fibronectin type III homologous repeats 2 and 3 of the neural cell adhesion molecule L1 as a neurite outgrowth promoting and signal transducing domain.

To determine the domains of the neural cell adhesion molecule L1 involved in neurite outgrowth, we have generated monoclonal antibodies against L1 and investigated their effects on neurite outgrowth of small cerebellar neurons in culture. When the 10 antibodies were coated as substrate, only antibody 557.B6, which recognizes an epitope represented by a synthetic peptide comprising amino acids 818 to 832 at the border between the fibronectin type III homologous repeats 2 and 3, was as efficacious as L1 in promoting neurite outgrowth, increasing intracellular levels of Ca2+, and stimulating the turnover of inositol phosphates. These findings suggest that neurite outgrowth and changes in these second messengers are correlated. Such a correlation was confirmed by the ability of Ca2+ channel antagonists and pertussis toxin to inhibit neurite outgrowth on L1 and antibody 557.B6. These observations indicate for the first time a distinct site on cell surface-bound L1 as a prominent signal-transducing domain through which the recognition events appear to be funneled to trigger neurite outgrowth, increase turnover of inositol phosphates, and elevate intracellular levels of Ca2+.
Risk factors of erectile dysfunction in patients receiving methadone maintenance therapy.

INTRODUCTION While methadone effectively treats opiate dependence, the side effect of erectile dysfunction (ED) may interfere with treatment adherence and benefits. AIM To determine the rate of ED and the associated factors which predict ED in male patients on methadone maintenance therapy (MMT) in a Malaysian population. MAIN OUTCOME MEASURES The main outcome measures were the International Index of Erectile Function-15 (IIEF-15) and the Beck Depression Inventory (BDI). METHODS A total of 108 participants diagnosed with heroin dependence were assessed. We used the Structured Clinical Interview for DSM-IV Axis-I Disorders (SCID-I) on subjects who received MMT, and they were assessed using the IIEF-15, the BDI, and measures of other clinical and sociodemographic variables. RESULTS The rate of ED among men on MMT was 68.5% (mild ED, 36.1%; mild to moderate ED, 22.2%; severe ED, 3.7%). The mean age of the participants was 43.45 years. Older age (P = 0.002), concurrent illicit heroin use (P = 0.024), and having an older partner (P = 0.039) were significantly associated with ED. Following multivariate analysis, it was found that older age was the only significant predictor of ED, with an adjusted odds ratio of 1.07 (95% CI = 1.02-1.16). Methadone dose and duration of methadone treatment were not significantly associated with ED. CONCLUSION ED was highly prevalent among male patients on MMT. This suggests that there is a need for routine assessment of sexual function in patients on methadone. Among the risk factors, age was the only factor that was significantly associated with ED. The current use of MMT in Malaysia in terms of dosage and duration did not pose a significant risk for ED.
Research on Factors Influencing the Sex Ratio at Birth Based on Spatial Data

This paper conducts empirical research based on the application of spatial econometric analysis of urban/subdivision cross-sectional data and geospatial data from year 2000.The results showed that the socio-economic and cultural factors influence reproductive decisions and reproductive behavior and the sex ratio at birth,various factors exist spatial autocorrelation.Traditional culture,public policy,and the level of urbanization will suppress the sex ratio at birth increase;economic development level,household income,and the level of education will lead to increase of sex ratio at birth.Fertility policy does not have statistical significance impact on the sex ratio at birth.
Astragalus polysaccharide, a component of traditional Chinese medicine, inhibits muscle cell atrophy (cachexia) in an in vivo and in vitro rat model of chronic renal failure by activating the ubiquitin-proteasome pathway

The present study aimed to determine the effect of Astragalus polysaccharide (APS) in an in vivo and in vitro rat model of muscle atrophy (cachexia) caused by chronic renal failure (CRF), along with the potential corresponding roles of atroglin-1 and the ubiquitin-proteasome pathway. A rat model of CRF was established using subtotal bilateral nephrectomy. It was observed by reverse transcription-quantitative polymerase chain reaction and western blot analysis that APS and the specific inhibitor of nuclear factor (NF)-κB, pyrrolidine dithiocarbamate (PDTC), significantly reduced the expression of atrogin-1, ubiquitin and the NF-κB subunit p65 mRNA in rat skeletal muscle in vivo and in vitro, respectively (P<0.05). NF-κB and PDTC also markedly reduced the expression of atrogin-1, ubiquitin and p65 protein. In addition, cultured rat myoblasts pretreated with tumor necrosis factor (TNF)-α exhibited significantly reduced expression of atrogin-1, ubiquitin and p65 mRNA in vitro (P<0.05). Fluorescence microscopy was subsequently used to evaluate TNF-α-treated myoblasts administered with APS or PDTC, whereby no evidence of muscle cell atrophy was observed in cells treated with APS. These data suggest that APS may delay muscle cell atrophy associated with cachexia in CRF by targeting atrogin-1 and the ubiquitin-proteasome pathway.
Phosphorus and nitrogen runoff from a forested watershed fertilized with biosolids.

Municipal biosolids are typically not used on the steepest of forested slopes in the U.S. Pacific Northwest. The primary concern in using biosolids on steep slopes is movement of biosolids particles and soluble nutrients to surface waters during runoff events. We examined the pattern and extent of P and N runoff from a perennial stream draining a small, forested 21.4-ha watershed in western Washington before and after biosolids application. In this study, we applied biosolids at a rate of 13.5 Mg ha(-1) (700 kg N ha(-1) and 500 kg P ha(-1)) to 40% of the watershed following nearly 1.5 years of pre-application water sampling and 1.5 years thereafter. There was no evidence of direct runoff of P or N from biosolids into surface water. Elevated surface water discharge did not change the concentration of PO4-P, biologically available phosphorus (BAP), bioavailable particulate phosphorus (BPP), or total P nor did it affect the concentration-discharge relationship. Some instances of total P concentrations exceeding the USEPA surface water standard of 0.1 mg L(-1) were observed following biosolids application. However, total P in 27 Creek was predominately in particulate form and not labile, suggesting that detritus moving into the main creek channel and ephemeral drainage courses may be the principal P source. Ammonium N concentrations in runoff water were consistent before and after biosolids application, ranging from below detection limits (0.01 mg L(-1)) to 0.1 mg L(-1); no concentration-discharge relationship existed. Biosolids application changed the 27 Creek concentration-discharge relationship for NO3(-)-N. Before application, no relationship existed. Beginning nine months after biosolids application, increases in discharge were positively related to increases in NO3(-)-N concentrations. Nitrate concentrations in runoff following biosolids application were approximately 10 times less than the USEPA drinking water standard of 10 mg L(-1).
Longitudinal Comparison of the Academic Performances of Asian‐American and White Medical Students

Purpose. To compare the academic performances of Asian‐American medical students — before, during, and after medical school — with those of white students. Method. The 140 Asian‐American graduates and 2,269 white graduates from the classes of 1981–1992 at Jefferson Medical College were studied prospectively: data on academic performance, indebtedness, and delayed graduation were analyzed and compared for all the graduates. F‐tests, chi‐square tests, and regression models were used. Results. The Asian‐Americans had statistically significantly higher scores on the SAT (Scholastic Aptitude Test) quantitative subtest and on the MCAT (Medical College Admission Test) chemistry, physics, and science problems subtests; the whites had significantly higher scores on the MCAT reading subtest; third‐year grade‐point averages for required clerkships; and scores on National Board of Medical Examiners Part I, II, and III examinations (NBME I, II, and III). No significant difference was found in the other performance measures, including ratings in the first year of residency. Regression analysis showed that the MCAT reading score was the major predictor of Asian‐Americans' performances on the NBME I and II. Conclusion. Because the MCAT reading score is the major predictor of later performance for Asian‐American students, schools should consider employing different criteria in predicting and monitoring these students' performances. Academic Medicine 68(1993):82–86.
Hodgkin's disease risk is increased in patients with ulcerative colitis.

BACKGROUND & AIMS All patients diagnosed with ulcerative colitis (UC) or Crohn's disease (CD) residing in Florence, Italy, in 1978-1992 were identified and included in a population-based study of cancer risk evaluation. METHODS A total of 920 patients were followed up (median, 11 years), and 64 newly diagnosed malignancies were identified by linkage to the local cancer registry. Expected cases were calculated on the basis of age- and sex-specific cancer incidence rates to estimate relative risks in comparison with the general population. RESULTS Overall, cancer incidence rates were not increased. A significant excess risk of Hodgkin's disease was observed among patients with UC (standardized incidence ratio, 9.3; 95% confidence interval [CI], 2.5-23.8). Respiratory tract cancers were significantly reduced to one fourth of the expected rate in patients with UC, but tended to be increased among patients with CD, who had a 50% higher risk of cancer at all sites. Only a nonsignificant, modestly increased risk of colorectal cancer was observed. CONCLUSIONS A strongly increased risk of Hodgkin's disease was evident in this first cancer follow-up of a representative series of patients with UC in a Mediterranean country. Two divergent risk patterns of respiratory tract cancers, possibly explained by differences in smoking habits, emerged in the 2 inflammatory bowel diseases.
Performance Analysis of Relay Selection in Two-Way Relay Networks With Channel Estimation Errors

The impact of channel estimation errors is investigated in two-way relay networks (TWRNs) with two different channel state information (CSI) estimation schemes, namely separate and cascaded. In the former scheme, the relay node is chosen in accordance with the CSI of the individual channels between the source nodes and the relay node. By contrast, in the latter scheme, relay node selection is performed in accordance with the CSI of the cascaded channel between the two source nodes. For both estimation schemes, the effect of the CSI estimation error on the outage probability is examined by means of the Cramér-Rao lower bound. Moreover, in contrast to previous studies, the source nodes in the TWRN are assumed to have different estimation errors. The numerical results confirm the validity of the derived expressions and show that the presence of different estimation errors at the two source nodes has a significant effect on the performance of the TWRN.
Functional MR Mapping of Activated Cortical Areas

Summary Magnetic resonance imaging (MRI) has recently been demonstrated to be sensitive to changes in neuronal activity of cortical areas. We report our initial experiences with functional MR brain mapping at high spatial resolution using a conventional whole-body MR system. A total of 10 visual and motor cortex activation studies were carried out on 8 healthy volunteers. In each examination, a time course series of 15 strongly T2*-weighted FLASH images was measured from three adjacent slices. The image analysis revealed a subtle but highly significant signal increase in cortical layers of gray matter in primary and associative visual as well as sensorimotoric cortex regions during periods of excessive brain activity provoked by photic stimuli or motoric tasks, respectively. To correlate brain structure and brain function, the computed MR brain activation maps were directly superimposed on T1-weighted anatomic spin-echo images. With this advance into the area of functional neuroimaging, MRI is moving into an established domain of positron emission tomography (PET). We, therefore, discuss the advantages and limitations of the MR method in comparison to PET as far as this can be done at present.