Miracle-dz/UniFAR-FTUs huggingface dataset:
Gender, Peer Relations, and Challenges for Girlfriends and Boyfriends Coming Together in Adolescence

This article examines how girls' and boys' different peer cultures in middle childhood may set the stage for challenges in emerging heterosexual romantic relationships in adolescence. Two theoretical frameworks are presented for understanding gender differences in children's same-gender friendships and peer groups in middle childhood: the two cultures perspective (Maccoby, 1998) and the emotional trade-offs perspective (Rose & Rudolph, 2006). Emerging empirical evidence is presented to highlight how girls' and boys' gendered friendship qualities may be linked to difficulties girls and boys have when they come together in early romantic relationships. Preliminary longitudinal data are presented that suggest that girls' relational and boys' physical aggression toward same-gender peers in middle childhood may relate to having emotionally intense arguments in early adolescence. Implications for prevention and intervention are discussed.
A Coarse-Grained Reconfigurable Architecture with Compilation for High Performance

We propose a fast data relay (FDR) mechanism to enhance existing CGRA (coarse-grained reconfigurable architecture). FDR can not only provide multicycle data transmission in concurrent with computations but also convert resource-demanding inter-processing-element global data accesses into local data accesses to avoid communication congestion. We also propose the supporting compiler techniques that can efficiently utilize the FDR feature to achieve higher performance for a variety of applications. Our results on FDR-based CGRA are compared with two other works in this field: ADRES and RCP. Experimental results for various multimedia applications show that FDR combined with the new compiler deliver up to 29% and 21% higher performance than ADRES and RCP, respectively.
Hamstring injury in athletes: using MR imaging measurements to compare extent of muscle injury with amount of time lost from competition.

OBJECTIVE The purpose of this study was to examine relationships between MR imaging measurements of the extent of hamstring injury and the amount of time lost from competition in a group of athletes. SUBJECTS AND METHODS Thirty-seven athletes with suspected hamstring injury underwent T1 and inversion recovery T2 turbo spin-echo MR imaging in axial and sagittal planes. The presence and dimensions of abnormal focal intra- and extramuscular T2 hyperintensity were independently recorded by two radiologists, and the muscles involved and intramuscular location of injury were noted. The percentage of abnormal cross-sectional muscle area, abnormal muscle volume, and length of extramuscular T2 hyperintensity were measured from T2-weighted images depicting the maximal extent of the injury. Time (days) lost from competition was noted during follow-up. RESULTS MR imaging detected hamstring muscle and linear extramuscular T2 hyperintensity in 30 (81%) and 25 (68%) of 37 athletes, respectively. The long head of the biceps was the dominant site of injury in 21 cases. The musculotendinous junction was involved in 28 (76%) of 37 cases. A relationship was seen between days lost from competition and percentage of abnormal muscle area (r = 0.63, p = 0.001) and volume of muscle affected (r = 0.46, p = 0.01), but only a trend for linear extramuscular T2 hyperintensity (r = 0.33, p = 0.12) was shown. CONCLUSION Rehabilitation time was related to MR measurements such as the percentage of abnormal muscle area and approximate volume of muscle injury. Hamstring injury most frequently involved the long head of the biceps femoris muscle, and involvement of the intramuscular tendon was common.
Telmisartan 80 mg/hydrochlorothiazide 25 mg single-pill combination in the treatment of hypertension

Introduction: International guidelines emphasize the importance of blood pressure (BP) control to reduce cardiovascular risk. Telmisartan, an angiotensin II receptor blocker, provides large BP reductions and also prevents cardiovascular events in patients at high risk. The thiazide diuretic, hydrochlorothiazide (HCTZ), has a complementary mode of action, and combination with telmisartan is an established and rational treatment option for patients uncontrolled on monotherapy. A single-pill combination (SPC) of telmisartan 80 mg with high-strength HCTZ 25 mg (T80/H25) is widely available. Area covered: Clinical data on T80/H25 SPC for the management of hypertension was identified via MEDLINE searches. T80/H25 SPC provides greater BP reductions and higher goal achievement rates in patients who cannot achieve BP goal with T80/HCTZ 12.5 mg SPC, and also as initial therapy compared with T80 monotherapy. T80/H25 also reduced BP significantly more than valsartan 160 mg/H25 combination, and demonstrated favorable tolerability in clinical trials. Expert opinion: Patients with hypertension often do not achieve BP goal, even when treated, leaving them at increased cardiovascular risk. In part this is due to poor adherence, which can be exacerbated by treatment side effects. High BP goal achievement with SPC T80/H25, with maintained tolerability, provides a treatment option for increasing BP control.
Emergence of carbapenemase-producing Enterobacteriaceae in France, 2004 to 2011.

Emergence of carbapenemase-producing Enterobacteriaceae (CPE) is currently a major public health concern worldwide. This study showed that 53 episodes of CPE infection or colonisation have been notified by French healthcare facilities since 2004. A sharp increase in the number of notifications was observed in the last three years. Oxacillinase (OXA)-48 and Klebsiella pneumoniae carbapenemase (KPC) beta-lactamases were the most frequent enzymes reported in these episodes. The index cases in most episodes were patients with a history of hospitalisation abroad within the previous year. Around a third of the episodes (n=18) led to secondary transmission in hospitals but most of them were controlled due to reinforced measures. Reinforcement of screening and control measures at national level when there is cross-border transfer of patients, along with overall reinforcement of infection control and antimicrobial stewardship worldwide, is urgently needed to contain the spread of CPE.
Responses of Black Neck ostrich chicks to L-carnitine dietary supplementation during the pre-starter growth period.

The objective was to determine the growth responses of Black Neck ostrich chicks to different dietary levels of L-carnitine in pre-starter diets. Thirty-two day-old ostrich chicks were randomly divided into four treatments with four replicates, each containing two chicks. All birds received the same basal diet supplemented with 0 (T0, control), 125 (T125), 250 (T250) or 600 (T600) mg L-carnitine per kg. Responses were monitored over three growth phases, 0 - 15, 16 - 30 and 31 - 60 days, the total period being 60 days. T600 had the lowest live weight (LW) and live weight gain (LWG) over the 60-day treatment period. Live weight and LWG values of T125 and T250 did not differ from those of T0. T600 had the worst feed conversion ratio (FCR) during the different stages (0 - 15, 16 - 30 and 31 - 60 days) and over the total 60-day period. Feed intake (FI) was reduced significantly in the T125 and T600 treatments compared to T0 and T250 treatments over the total period. The treatment, T125, showed the lowest FI and FCR responses over the total period, whereas there was no difference between T0 and T250. The results suggest that supplementing the pre-starter diet with 125 mg/kg of L-carnitine can improve the performance of ostrich chicks by decreasing the FCR. In contrast, the suppressive effect of a high inclusion level (T600) might indicate that ostrich chicks are sensitive to a high level of inclusion that could cause adverse effects.
Regulation of HER expression and transactivation in human prostate cancer cells by a targeted cytotoxic bombesin analog (AN‐215) and a bombesin antagonist (RC‐3095)

Bombesin (BN) and gastrin‐releasing peptide (GRP) have been shown to stimulate the growth of human prostate cancer in vivo and in vitro by mechanisms initiated by binding of the peptide to BN/GRP receptor (GRPR). GRPR is overexpressed in a variety of human cancers, including human prostatic carcinoma. This led us to evaluate the effectiveness of blocking GRPR and of chemotherapy targeted to GRPR in androgen‐dependent (LNCaP) and androgen‐independent (PC‐3) prostate cancer cells, which exhibit different features of disease progression. Thus, we used a cytotoxic BN/GRP analog, AN‐215, consisting of 2‐pyrrolinodoxorubicin (AN‐201) linked to BN‐like carrier peptide, and a BN/GRP receptor antagonist, RC‐3095. Semiquantitative RT‐PCR and Western blotting revealed that mRNA and protein levels for GRPR increased in prostate cancer cells as compared with nonneoplastic RWPE‐1 cells. Immunofluorocytochemistry and Western blot assays revealed that AN‐215 was the most effective analog decreasing both the expression of epidermal growth factor receptor family members and the activation of epidermal growth factor receptor and HER‐2, which are associated to a poor prognosis. Furthermore, analogs targeted to BN/GRP receptors, AN‐215 and RC‐3095, blocked the effect of BN on cell growth in RWPE‐1, LNCaP and PC‐3 cells. These findings shed light on the mechanisms of action of these analogs and support the view that the use of AN‐215 and RC‐3095 for blocking BN/GRP receptors for targeted therapy may be of benefit for treatment of advanced prostate cancer.
Differences in the Defense Mechanism Technique modified (DMTm) between Depressive and Somatoform Disorder Patients

Differences in the Defense Mechanism Technique modified (DMTm), a percept-genetic tachistoscopic technique, between 56 patients with a main diagnosis of mild, moderate or severe unipolar depression and 42 with a main diagnosis of somatoform disorder were studied. As expected, the affect defenses of inhibition, introaggression and barrier isolation—all through their specified motive related to the depressive position of the affect positions model of the Andersson developmental and psychodynamic model of the mind—appeared more often with the depressive than the somatoform patients. Repression scored at the place of the threatening person in the DMTm pictures (Pp-repression) was more often found with the depressive patients, projected introaggression and no Pp-repression but repression scored at the place of the non-threatening person (H-repression) with the somatoform. In total less than four scorings of affect anxiety and affect defense, seen to indicate alexithymia, characterized the somatoform patients and those with mild depression. Denial through reversal II 3 and denial through reversal IV were common with the somatoform patients and those with severe depression. Denial was uncommon with mild depression. Denial, denial through reversal II 3 and denial through reversal IV increased the more severe the depression. The findings were interpreted according to the Andersson model.
Different from the HIV Fusion Inhibitor C34, the Anti-HIV Drug Fuzeon (T-20) Inhibits HIV-1 Entry by Targeting Multiple Sites in gp41 and gp120*

Fuzeon (also known as T-20 or enfuvirtide), one of the C-peptides derived from the HIV-1 envelope glycoprotein transmembrane subunit gp41 C-terminal heptad repeat (CHR) region, is the first member of a new class of anti-HIV drugs known as HIV fusion inhibitors. It has been widely believed that T-20 shares the same mechanism of action with C34, another C-peptide. The C34 is known to compete with the CHR of gp41 to form a stable 6-helix bundle (6-HB) with the gp41 N-terminal heptad repeat (NHR) and prevent the formation of the fusogenic gp41 core between viral gp41 NHR and CHR, thereby inhibiting fusion between viral and target cell membranes. Here we present data to demonstrate that, contrary to this belief, T-20 cannot form stable 6-HB with N-peptides derived from the NHR region, nor can it inhibit the 6-HB formation of the fusogenic core. Instead, it may interact with N-peptides to form unstable or insoluble complexes. Our data suggest that T-20 has a different mechanism of action from C34. The interaction of T-20 with viral NHR region alone may not prevent the formation of the fusion active gp41 core. We also demonstrate that the T-20-mediated anti-HIV activity can be significantly abrogated by peptides derived from the membrane-spanning domain in gp41 and coreceptor binding site in gp120. These new findings imply that T-20 inhibits HIV-1 entry by targeting multiple sites in gp41 and gp120. Further elucidation of the mechanism of action of T-20 will provide new target(s) for development of novel HIV entry inhibitors.
Pediatric Floating Elbow

A retrospective review of 16 patients with floating elbow injuries over a 9-year period at a tertiary care children's hospital confirms that these injuries are associated with substantial swelling and the potential to develop compartment syndrome, particularly when circumferential cast immobilization is used. Among 10 patients in whom the forearm was treated with closed reduction and plaster immobilization, a compartment syndrome developed in 2, and 4 patients had incipient compartment syndrome that responded to splitting of the cast; 3 of these subsequently required remanipulation of the distal radius. One patient with compartment syndrome had Volkmann ischemic contracture. Six patients underwent stabilization of both the distal humeral and forearm fractures with percutaneously inserted Kirschner wires, thereby allowing postreduction immobilization in a split cast. None of these patients had problems with excessive swelling or compartment syndrome. Percutaneous Kirschner wire fixation of both the humeral and forearm fractures in pediatric floating elbow injuries allows noncircumferential immobilization, thereby reducing the risk of compartment syndrome.
Differential Effects of Long-Term Potentiation Evoked at the CA3–CA1 Synapse before, during, and after the Acquisition of Classical Eyeblink Conditioning in Behaving Mice

Experimentally induced long-term potentiation (LTP) is a persistent increase in synaptic strength that decays across time. In contrast, changes in synaptic strength during actual learning are gradual processes that increase with training. We have studied here the effects of LTP evoked before, during, and after the acquisition of a well known associative learning paradigm: the classical eyeblink conditioning. We used a trace paradigm, with a tone as the conditioned stimulus (CS) and an electric shock presented to the supraorbital nerve as the unconditioned stimulus (US). A single electrical pulse was presented to the Schaffer collateral-commissural pathway to evoke field EPSPs (fEPSPs) during the CS–US interval. LTP induced by high-frequency stimulation of the Schaffer collaterals lasted for 6–10 d. When LTP was evoked before conditioning, animals were unable to acquire conditioned eyeblinks if the training started 8 d after LTP disappearance, and no change was detected in fEPSP evoked at the CA3–CA1 synapse during conditioning. In contrast, LTP-induced animals learned as did controls when the conditioning test was presented 20 d after LTP had decayed to baseline, and presented a normal increase in fEPSP slopes across conditioning. When evoked during the first two conditioning sessions, LTP prevented both eyeblink conditioning and fEPSP increase. Finally, LTP did not disrupt the normal performance of a recall test of a previously acquired eyeblink conditioning. In this latter experiment, both the LTP-induced potentiation of fEPSPs and their physiological potentiation decayed across time with a similar time constant, with no apparent effect on memory recall.
Is the Fusiform Face Area Specialized for Faces, Individuation, or Expert Individuation?

Several brain imaging studies have identified a region of fusiform gyrus (FG) that responds more strongly to faces than common objects. The precise functional role of this fusiform face area (FFA) is, however, a matter of dispute. We sought to distinguish among three hypotheses concerning FFA function: face specificity, individuation, and expert individuation. According to the face-specificity hypothesis, the FFA is specialized for face processing. Alternatively, the FFA may be specialized for individuating visually similar items within a category (the individuation hypothesis) or for individuating within categories with which a person has expertise (the expert-individuation hypothesis). Our results from two experiments supported the face-specificity hypothesis. Greater FFA activation to faces than Lepidoptera, another homogeneous object class, occurred during both free viewing and individuation, with similar FFA activation to Lepidoptera and common objects (Experiment 1). Furthermore, during individuation of Lepidoptera, 83 of activated FG voxels were outside the face FG region and only 15 of face FG voxels were activated. This pattern of results suggests that distinct areas may individuate faces and Lepidoptera. In Experiment 2, we tested Lepidoptera experts using the same experimental design. Again, the results supported the face-specificity hypothesis. Activation to faces in the FFA was greater than to both Lepidoptera and objects with little overlap between FG areas activated by faces and Lepidoptera. Our results suggest that distinct populations of neurons in human FG may be tuned to the features needed to individuate the members of different object classes, as has been reported in monkey inferotemporal cortex, and that the FFA contains neurons tuned for individuating faces.
Evidence that Individual Variations in TP53 and CDKN1A Protein Responsiveness are Related to Inherent Radiation Sensitivity

Abstract Alsbeih, G. , Torres, M. , Al-Harbi, N. and Al-Buhairi, M. Evidence that Individual Variations in TP53 and CDKN1A Protein Responsiveness are Related to Inherent Radiation Sensitivity. Radiat. Res. 167, 58–65 (2007). We tested the hypothesis that individual variations in the induction of the TP53 tumor suppressor protein by radiation are related to inherent radiosensitivity. Thirty-two fibroblast cell strains were examined. Radiosensitivity was measured by a clonogenic survival assay. The induction of TP53 and its transcriptionally activated CDKN1A (p21) protein were studied by Western blotting 3 h after a single dose of 5 Gy. The relative cell culture age, as determined by the colony size distribution, was studied as a confounding factor. Survival curves showed wide range of radiosensitivity. The surviving fraction at 2 Gy (SF2) ranged between 0.02 and 0.49 (mean = 0.29, SD = 0.13). TP53 induction ranged between 1.28 and 2.34 (mean = 1.80, SD = 0.31). CDKN1A showed a wider induction (1.09–4.05, mean = 2.33, SD = 0.78). Positive correlations were observed between SF2 and TP53 induction (R2 = 0.62, P < 0.001) and CDKN1A (R2 = 0.64, P < 0.001). No correlation with the colony size distribution was observed. In conclusion, these results suggest that the individual variations in radiosensitivity and in the level of induction of TP53 (and consequently CDKN1A) are congruent, irrespective of the genetic background of these nontransformed fibroblasts. It is postulated that underlying mechanisms culminating in a stronger TP53 induction lead to higher survival, presumably due to more efficient repair of radiation-induced damage.
Effects of Ramadan Fasting on Stroke

The effects of fasting on humans have not been adequately investigated. Ramadan fasting is a great opportunity for scientific research due to its peculiar nature. With this in mind, we conducted research on the effects of Ramadan on stroke, which is one of the most common causes of death in adults. Patients hospitalized solely for ischemic stroke and intracerebral hemorrhage were evaluated retrospectively. The ratio of these cases to other patients hospitalized in the neurology department was determined. The in-hospital clinical course and mortality rates of the patients with stroke were evaluated. Within the entire cohort, the most frequently encountered type of stroke was ischemic (P 0.05). The ratio of hemorrhagic stroke decreased in hypertensive patients during Ramadan (P < 0.05). In diabetic patients, the ratio of ischemic stroke increased in the month of Ramadan significantly (P < 0.05). Although Ramadan fasting had an adverse effect on diabetic patients with ischemic stroke, there was no negative effect on hypertensive patient with hemorrhagic stroke or stroke frequency. However, further prospective studies are needed to confirm our results. We think that to understand the effects of Ramadan fasting on stroke in humans evaluation in terms of risk factors such as diabetes and hypertension is required.
Serum Proteomic Analysis of Extracorporeal Shock Wave Therapy–Enhanced Diabetic Wound Healing in a Streptozotocin-Induced Diabetes Model

Background: Previous studies have demonstrated that extracorporeal shock wave therapy has a significant positive effect on accelerating diabetic wound healing. However, the systemic effect after therapy is still unclear. Methods: This study investigated the plasma protein expression in the extracorporeal shock wave therapy group and diabetic controls using proteomic study. A dorsal skin defect (6 × 5 cm) in a streptozotocin-induced diabetic Wistar rat model was used. Diabetic rats receiving either no therapy or extracorporeal shock wave therapy after wounding were analyzed. The spots of interest were subjected to in-gel trypsin digestion and matrix-assisted laser desorption ionization time-of-flight mass spectrometry to elucidate the peptide mass fingerprints. The mass spectrometric characteristics of the identified proteins, including their theoretical isoelectric points, molecular weights, sequence coverage, and Mascot score, were analyzed. Protein expression was validated using immunohistochemical analysis of topical periwounding tissues. Results: The proteomic study revealed that at days 3 and 10 after therapy rats had significantly higher abundance of haptoglobin and significantly lower levels of the vitamin D-binding protein precursor as compared with the diabetic controls. Immunohistochemical staining of topical periwounding tissue also revealed significant upregulation of haptoglobin and downregulation of vitamin D-binding protein expression in the extracorporeal shock wave therapy group, which was consistent with the systemic proteome study. Conclusion: Proteome analyses demonstrated an upregulation of haptoglobin and a downregulation of vitamin D-binding protein in extracorporeal shock wave therapy–enhanced diabetic wound healing.
Tissue Factor Pathway Inhibitor-2 Is a Novel Mitogen for Vascular Smooth Muscle Cells*

A mitogen for growth-arrested cultured bovine aortic smooth muscle cells was purified to homogeneity from the supernatant of cultured human umbilical vein endothelial cells by heparin affinity chromatography and reverse-phase high performance liquid chromatography. This mitogen was revealed to be tissue factor pathway inhibitor-2 (TFPI-2), which is a Kunitz-type serine protease inhibitor. TFPI-2 was expressed in baby hamster kidney cells using a mammalian expression vector. Recombinant TFPI-2 (rTFPI-2) stimulated DNA synthesis and cell proliferation in a dose-dependent manner (1–500 nm). rTFPI-2 activated mitogen-activated protein kinase (MAPK) activity and stimulated early proto-oncogene c-fos mRNA expression in smooth muscle cells. MAPK, c-fos expression and the mitogenic activity were inhibited by a specific inhibitor of MAPK kinase, PD098059. Thus, the mitogenic function of rTFPI-2 is considered to be mediated through MAPK pathway. TFPI has been reported to exhibit antiproliferative action after vascular smooth muscle injury in addition to the ability to inhibit activation of the extrinsic coagulation cascade. However, structurally similar TFPI-2 was found to have a mitogenic activity for the smooth muscle cell.