Miracle-dz/UniFAR-FTUs huggingface dataset:
Nutrition, child growth, and chronic disease prevention

Countries undergoing the nutrition transition are experiencing a progressive increase in obesity and nutrition‐related chronic diseases (NRCDs). In transitional countries, stunting (shortness for age) and micronutrient deficiencies (iron, vitamin A, and zinc) in children coexist with obesity and NRCDs originating the double burden of nutritional disease. The causal web for obesity and NRCDs is complex and multifaceted; changes in diet and physical activity of the population are likely the main concurrent determinant factors. However, recent evidence suggests that specific patterns of prenatal and postnatal growth are also potential contributors. Evidence indicates that intervention strategies to prevent malnutrition should emphasize improvements in linear growth in the first 2–3 years of life rather than aim at gaining weight. Avoiding excessive weight gain relative to height gain (BMI) is especially relevant after the first 2 years of life. Routine assessment of child growth based on the new World Health Organization (WHO) standard, defining energy needs based on the recent Food and Agricultural Organization (FAO)/WHO norms, and providing critical micronutrients to support lean mass growth are critical to prevent obesity and NRCDs starting early in the life course. These actions should contribute in the prevention and control of obesity in childhood and thus help prevent NRCDs in future generations of adults.
Disease-modifying treatments for Alzheimer’s disease

The first drugs developed for Alzheimer’s disease (AD), acetylcholinesterase inhibitors (AChEI), increase acetylcholine levels, previously demonstrated to be reduced in AD. To date, four AChEI are approved for the treatment of mild-to-moderate AD. A further therapeutic option available for moderate-to-severe AD is memantine. These treatments are symptomatic, whereas drugs under development are intended to modify the pathological steps leading to AD, thus acting on the evolution of the disease. For this reason they are have been termed ‘disease-modifying’ drugs. To block the progression of the disease they have to interfere with the pathogenic steps responsible for the clinical symptoms, including the deposition of extracellular amyloid beta (Aβ) plaques and of intracellular neurofibrillary tangles, inflammation, oxidative damage, iron deregulation and cholesterol metabolism. In this review, new perspectives will be discussed. In particular, several approaches will be described, including interference with Aβ deposition by anti-Aβ aggregation agents, vaccination, γ-secretase inhibitors or selective Aβ-lowering agents; interference with tau deposition by methylthioninium chloride; and reduction of inflammation and oxidative damage.
The impact of social media and offline influences on consumer behaviour. An analysis of the low-cost airline industry

This study analyses the impact of social media as well as offline environments upon tourist online purchase and recommendation behaviour of low-cost airline services. Drawing on the Theory of Reasoned Action (TRA), this research considers the effect of offline social influences (interpersonal and external influences) and analyses online Consumer-to-Consumer (C2C) information exchanges as a driver of customer attitude towards online purchases. We propose that these factors improve online repurchase intentions and positive word-of-mouth communication (WOM and e-WOM) in low-cost settings. Using structural equation modelling, the conceptual model is tested with a sample of 441 Spanish Internet buyers of low-cost airline services. Interpersonal offline influences (e.g. friends, relatives, and family) have a significant effect on online repurchase intentions and WOM but do not affect e-WOM. External offline influences (e.g. media and experts), however, only affect consumer intentions to recommend future purchases of low-cost airline services on social networking travel sites and have no effect on online repurchase intentions or WOM. Findings also show that online C2C information exchanges influence attitude which, in turn, has a significant effect on repurchase intentions WOM and e-WOM.
Assessing the Factors Influencing Migration Decision of Climate Refugees in Coastal Areas of Bangladesh

The major impacts of climate change play a substantial role in triggering human migration, especially in the coastal areas. The individual or combined effects of climate change are likely to trigger mass human movement both within and across international borders. People rarely move for a single reason; the motivation to migrate is complex of many factors. The main goal of this article is to identify the factors related to the decision to migrate taken by refugees in the coastal area. To assess this objective we employ exploratory factor analysis and structural equation modeling (SEM) and find that different factors influence refugees’ migration decision differently. From the findings, it is seen that loss of shelter, extreme events, decreasing soil fertility and food shortage, variability in temperature patterns and exhaustion of natural resources are the most important environmental factors that affect the decision to migrate of climate refugees. Low income, increasing price, decreasing purchasing power are the most important economic factors that influence migration decision. No social factors have significant effect on migration decision while safety as a political factor has a moderate influence on refugees’ decision to migrate. Finally, this article provides some recommendations for recognition of and protection for migrants forced to move to safer places due to certain direct impacts of climate change, notwithstanding the existence of multi-causality.
Midazolam premedication for Ketamine-induced emergence phenomenon: A prospective observational study

Objective: Ketamine administration is known to induce hemodynamic pressor response and psychomimetic effects which could be attenuated by appropriate premedication. The present study was designed to evaluate the effect of midazolam on hemodynamic stability and postoperative emergence phenomenon following ketamine anesthesia. Methods: This was a prospective observational study including 30 adult patients with American Society of Anesthesiologists physical grades I and II scheduled for elective short surgeries under ketamine anesthesia. Patients were premedicated with midazolam (0.02 mg/kg intravenously) before the ketamine induction (1 mg/kg intravenously). Demographic data and hemodynamic variables were observed during the perioperative period. Pain score by visual analog scale score and psychomimetic effects were recorded postoperatively. Findings: The mean ± standard deviation of heart rate, systolic blood pressure, diastolic blood pressure, and respiratory rate were decreased postoperatively (85.3 ± 11.4, 120.7 ± 8.2, 79.2 ± 5.5, 13.5 ± 1.8, respectively) compared to intraoperative period (88.53 ± 14.1, 123.83 ± 13.8, 83 ± 9.1, 14.13 ± 2.0, respectively). There was statistically significant decrease in systolic (P = 0.03) and diastolic (P = 0.002) blood pressure, but not with heart rate and respiratory rate. Eighty percent of patients had no pain at ½ hour and 1 hour, while this increased to 90% at 2 hours postoperatively. Mild emergence delirium was noted in 13.3% and 16.7% at ½ hour and 1 hour, respectively, which decreased to 13.3% at 2 hours. Dreams were noticed in 20%, 27% and 10% of patients at ½ hour, 1 and 2 hours after surgery, respectively. Conclusion: Midazolam premedication in ketamine anesthesia effectively attenuated the hemodynamic pressor response and postoperative emergence phenomenon. Hence, the combination of midazolam with ketamine can be safely used for short surgical painful procedures in adults.
The Antifibrinolytic Drug Tranexamic Acid Reduces Liver Injury and Fibrosis in a Mouse Model of Chronic Bile Duct Injury

Hepatic fibrin deposition has been shown to inhibit hepatocellular injury in mice exposed to the bile duct toxicant α-naphthylisothiocyanate (ANIT). Degradation of fibrin clots by fibrinolysis controls the duration and extent of tissue fibrin deposition. Thus, we sought to determine the effect of treatment with the antifibrinolytic drug tranexamic acid (TA) and plasminogen activator inhibitor-1 (PAI-1) deficiency on ANIT-induced liver injury and fibrosis in mice. Plasmin-dependent lysis of fibrin clots was impaired in plasma from mice treated with TA (1200 mg/kg i.p., administered twice daily). Prophylactic TA administration reduced hepatic inflammation and hepatocellular necrosis in mice fed a diet containing 0.025% ANIT for 2 weeks. Hepatic type 1 collagen mRNA expression and deposition increased markedly in livers of mice fed ANIT diet for 4 weeks. To determine whether TA treatment could inhibit this progression of liver fibrosis, mice were fed ANIT diet for 4 weeks and treated with TA for the last 2 weeks. Interestingly, TA treatment largely prevented increased deposition of type 1 collagen in livers of mice fed ANIT diet for 4 weeks. In contrast, biliary hyperplasia/inflammation and liver fibrosis were significantly increased in PAI-1−/− mice fed ANIT diet for 4 weeks. Overall, the results indicate that fibrinolytic activity contributes to ANIT diet–induced liver injury and fibrosis in mice. In addition, these proof-of-principle studies suggest the possibility that therapeutic intervention with an antifibrinolytic drug could form a novel strategy to prevent or reduce liver injury and fibrosis in patients with liver disease.
Interaction in the radio news interview: a case study of BBC Radio 4's the Today programme and the Human Fertilisation and Embryology Act 2008

News interviews are core within current practices of journalism. They point to the existence of a mediated public space and bolster the concept of democratic accountability. This research investigates what impact these concepts have on the news interviews broadcast by the Today programme (BBC Radio 4) and how interaction within them invoked the public. The programme has a responsibility to uphold the democratic life of the UK, making it a compelling focus of research. The case study examined in this thesis is the broadcast of news interviews concerning the Human Fertilisation and Embryology Act 2008 (HFEA 2008) and how they shaped representations of the biomedical techniques contained within the legislation. In particular, research investigated what the news interviews reveal about the biological citizen: a specific configuration of citizenship increasingly important in the twenty first century. The research method is Conversation Analysis and the news interviews as broadcast are the empirical data on which findings are based. The study contributes to the understanding of the method through the investigation of the structural organisation of the news interviews and how this affected interaction. Findings suggest that the news interviews on the Today programme highlights the political dimensions of the HFEA 2008, that interviewees were predominantly MPs or public figures and that the gender ratio is skewed towards male voices. It points to the fact that the programme prefers news interviews that contain two interviewees, as this promotes adversarial encounters within interaction. Research also establishes how interviewers have at their disposal a range of devices, such as third party citations, which they use within questions in order to achieve a neutral posture. A further set of findings uncovers the need of interviewees to maintain a positive image of themselves, employing politeness strategies in order to co-operate when answering a question.
On the Tradeoff Between Spectral Efficiency and Energy Efficiency of Homogeneous Cellular Networks With Outage Constraint

In this paper, the tradeoff relationship between the spectral efficiency (SE) and energy efficiency (EE) of homogenous cellular networks in which the BSs are arbitrarily distributed is investigated. The network performance metrics of SE and EE are assessed subject to a downlink transmission outage constraint in interference-limited operational environments. The EE is expressed in closed form as a function of SE, based on which the performance bounds of the network are derived. Unlike the traditional inverse relationship between SE and EE, it is found in this paper that there exists an operational regime for which both the SE and EE increase while satisfying the outage requirement, and the density of base stations (BSs) simultaneously sharing the spectrum is optimal. The difference in the performance achieved for the SE when operating in the EE maximizing mode as compared with the SE maximizing mode strongly depends on the received signal-to-interference ratio (SIR) threshold. In the SE–EE tradeoff regime, the analytical tools from microeconomics theory are applied to determine the optimal BS density with respect to the utility achieved by the network operator via balancing the SE and EE objectives. Numerical results show that, by tuning a preference factor toward either the SE or EE metrics, it is feasible to realize Pareto optimal performance.
Are the Macroeconomic Effects Greater from an Oil Price Shock or a Global Oil Demand Shock?

Since a higher oil price has preceded ten out of the last eleven U.S. recessions, the macroeconomic responses to different oil market shocks concern policymakers. Although these responses might be declining, there is evidence indicating it is not fluctuations in the oil price that matters but the underlying causes of the fluctuation. The primary underlying cause since the 1970s has been from a global oil demand shock. This paper examines whether the macroeconomic responses to a global oil demand shock are greater than to oil price shocks caused by other oil market factors. Estimating a four-variable VAR with quarterly data from 1974:1-2011:3 and constructing a structural VAR with long-run restrictions, I compare the responses to natural rate of unemployment, global oil demand or oil price, aggregate supply, and aggregate demand shocks on the unemployment rate, economic output, and the headline and core inflation rates. The results indicate that the responses to a global oil demand shock are greater than from other oil market shocks. Policymakers should not necessarily be concerned with the price of oil, but how their policies influence, or react, to global economic activity.
Pro-environmental behavior in sport event tourism: roles of event attendees and destinations

Abstract Sport event tourism destinations hope that their green event operations will encourage event attendees to adopt pro-environmental behaviors. Yet little research has examined whether event attendees have greater awareness of destination environmental responsibility and whether, if so, it improves their environmental behavior. This study aims to examine whether sport event attendees' pro-environmental behavior at home differs from their behavior at sport event tourism destination; and assess whether the difference of pro-environmental behavior between two settings is affected differently depending on sport event attendee' characteristics. Study participants are sport event attendees who were tailgaters in a university campus in the Midwest region of the USA. Onsite systematic sampling was conducted in 2013. After distributing follow-up surveys, a total of 514 surveys were collected. Results of the paired-sample t-tests indicated that study participants' self-reported recycling behavior scores decreased from home to the sport event setting. Furthermore, results of mixed between-within subjects ANOVAs revealed that the degree of decrease in sport event attendees' pro-environmental behavior from home to sport event tourism destination is different depending on event attendees' perception of destination environmental responsibility and event attendee sub-types (i.e., tourist vs. non-tourist). Theoretical discussions and managerial implications are presented.
Macular Ganglion Cell–Inner Plexiform Layer and Retinal Nerve Fiber Layer Thickness in Eyes With Primary Open-Angle Glaucoma Compared With Healthy Saudi Eyes: A Cross-Sectional Study

PurposeWe compared the thickness of the ganglion cell–inner plexiform layer at the macula (mGCIPL) and the thickness of the retinal nerve fiber layer (RNFL) in different regions of the retina in eyes with primary open-angle glaucoma (POAG group) and normal eyes (control group). DesignThis was a cross-sectional study performed in 2014. MethodsSpectral domain optical coherence tomography (SD-OCT) was used to measure mGCIPL and RNFL thickness. Age-adjusted means and standard deviation were calculated. Age, sex, refractive status, corneal thickness, and stage/severity of glaucoma (defined by vertical cup-to-disc ratio and visual field changes) were associated to outcomes. Statistical significance was indicated by P < 0.05. ResultsThere were 50 eyes in the POAG group and 52 eyes in the control group. The difference in age between patients in both groups was statistically significant (P < 0.001). The age-adjusted measurements were thinner for POAG with a mean difference (DF) of 11.1 &mgr;m for mGCIPL and 8 &mgr;m for mRNFL. The mGCIPL to mRFNL ratio was 2.1 in the POAG group and 1.9 in the control group (degrees of freedom = 0.2, P = 0.001). The mGCIPL and RNFL thickness decreased as the severity of glaucoma increased. The mGCIPL to mRNFL ratio was a predictor of the severity of field defects in POAG (AUROC = 0.66, P = 0.0002). Age and myopia were confounders to the association of OCT findings and the visual field changes in POAG (P = 0.07). ConclusionsThere was generalized thinning of retinal layers in eyes of nondiabetic Arab patients with POAG. OCT parameters can be important for detecting and monitoring glaucoma cases.
Fundamentals News, Global Liquidity and Macroprudential Policy

We study optimal macroprudential policy in a model in which unconventional shocks, in the form of news about future fundamentals and regime changes in world interest rates, interact with collateral constraints in driving the dynamics of financial crises. These shocks strengthen incentives to borrow in good times (i.e. when “good news” about future fundamentals coincide with a low-world-interest-rate regime), thereby increasing vulnerability to crises and enlarging the pecuniary externality due to the collateral constraints. Quantitatively, an optimal schedule of macroprudential debt taxes can lower the frequency and magnitude of financial crises, but the policy is complex because it features significant variation across interest-rate regimes and news realizations.
Hydrogen peroxide-producing lactobacilli and acquisition of vaginal infections.

This cohort study of 182 women attending a sexually transmitted disease clinic evaluated the hypothesis that women colonized by lactobacilli have decreased acquisition of vaginal infections. During a 2-year follow-up, 50 women acquired bacterial vaginosis (BV), 25 acquired symptomatic vulvovaginal candidiasis (VVC), and 7 acquired vaginal trichomoniasis. By multivariate analysis, utilizing Cox proportional hazards modeling with time-dependent covariates, acquisition of BV was independently associated with lack of vaginal H2O2-producing lactobacilli (hazard ratio [HR] = 4.0, P < .001) or presence of only non-H2O2-producing lactobacilli (HR = 2.2, P = .02). Acquisition of BV was associated with having a new sex partner (HR = 2.5, P = .004) and with douching for hygiene (HR = 2.1, P = .05). Absence of lactobacilli did not increase acquisition of VVC. Trichomoniasis was associated only with having a new sex partner (HR = 4.7, P = .05). These results support the hypothesis that H2O2-producing vaginal lactobacilli protect against acquisition of BV but do not protect against VVC or vaginal trichomoniasis.
Lower rates of hypoglycemia during maintenance treatment with insulin degludec/insulin aspart versus biphasic insulin aspart 30: a combined analysis of two Phase 3a studies in type 2 diabetes

Insulin degludec/insulin aspart (IDegAsp) is a soluble coformulation of the basal analog insulin degludec and the rapid‐acting prandial insulin aspart in a single injection. The present combined analysis of two Phase 3a trials compared the incidence of hypoglycemia in participants treated twice daily with IDegAsp or biphasic insulin aspart 30 (BIAsp 30).
Rck2, a member of the calmodulin-protein kinase family, links protein synthesis to high osmolarity MAP kinase signaling in budding yeast

Rck2, a yeast Ser/Thr protein kinase homologous to mammalian calmodulin kinases, requires phosphorylation for activation. We provide evidence that in budding yeast, this step can be executed by the osmostress-activated mitogen-activated protein kinase Hog1. Rck2 phosphorylation was transiently increased during osmostress or in mutants with a hyperactive high osmolarity glycerol (HOG) pathway. This modification depended on catalytically active Hog1 kinase and two putative mitogen-activated protein kinase phosphorylation sites in Rck2. Immunokinase assays showed that Hog1 can directly phosphorylate Rck2 to stimulate its enzymatic activity toward translation elongation factor 2. We demonstrate that Hog1 and Rck2 are necessary for attenuation of protein synthesis in response to osmotic challenge and show that modification of elongation factor 2 induced by osmostress depends on Rck2 and Hog1 in vivo. Therefore, we propose that the transient down-regulation of protein synthesis after osmotic shock is a response not to damage but to an extracellular signal mediated by Hog1 and Rck2.
Dyschromatosis symmetrica hereditaria with cutaneous lupus erythematosus and hyperthyroidism

Dyschromatosis symmetrica hereditaria (DSH) is a rare genodermatosis characterized by various sizes of both hyper- and hypopigmented macules arranged in reticulated patterns on the face and the dorsal aspects of the extremities. There are also cutaneous and extracutaneous abnormalities, but they are rare. As far as we know, DSH associated with immune-mediated conditions has not been reported. We report the first case of DSH, which is associated with cutaneous lupus erythematosus and hyperthyroidism.
Demand Side Secular Stagnation

The experience of first Japan and now Europe and the USA suggests that Hansen's concept of secular stagnation is highly relevant. Recovery has been anemic and follows a generation of financially unsustainable and often lackluster growth. Investment demand has declined while the supply of saving has increased, leaving the economy vulnerable to liquidity traps. Although some US indicators have improved, forward real rates have declined sharply, European prospects remain muddled, and the zero-bound will likely constrain again during the next recession. Infrastructure and private investment are the best ways to both minimize the risk of secular stagnation and raise demand.