Miracle-dz/UniFAR-FTUs huggingface dataset:
Fatigue and Recovery in Soccer: Evidence and Challenges

Background : Soccer presents physiological, metabolic, physical and psychological demands which can deteriorate players’ performance due to fatigue. The high variability in physiological, metabolic, physical and psychological responses also influences the magnitude of exercise-induced muscle damage, with symptoms negatively affecting neuromuscular function during recovery or subsequent training sessions or matches. Consequently, more precise and consistent knowledge is required in this area to optimize training and performance. Objective : Therefore, the purpose is to sum-up current evidence on fatigue and recovery in soccer players, to shed light on factors that can affect players’ performance, and to suggest applications for coaches and further research. Method : A comprehensive review of the scientific literature on the field was conducted. Results : Physical performance decrements during matches have traditionally been associated with physiological fatigue, but the magnitude of the symptoms in soccer players is unclear and depends on several factors. Moreover, the decline in physical performance during a soccer match is related to specific demands of each match. These could explain inter-individual variability in acute fatigue or training recovery processes when comparing players from the same team. Recovery counteracts the effects of fatigue, both peripheral and central, but there is a lack of consensus about the usefulness of tests used to monitor fatigue and recovery kinetics. Conclusion : Although fatigue and recovery in soccer has been extensively studied, there are still uncertainties about the underlying mechanisms because they are influenced by physiological and match-related demands.
Effectiveness of Team Training on Fall Prevention

A longitudinal, repeated-measures design with intervention and comparison groups was used to evaluate the effect of a training curriculum based on TeamSTEPPS with video vignettes focusing on fall prevention. Questionnaires, behavioral observations, and fall data were collected over 9 months from both groups located at separate hospitals. The intervention group questionnaire scores improved on all measures except teamwork perception, while observations revealed an improvement in communication compared with the control group. Furthermore, a 60% fall reduction rate was reported in the intervention group. Team training may be a promising intervention to reduce falls.
Functional topography of the rat hypothalamic dopamine neuron systems: Retrograde tracing and immunohistochemical study

The origins of the dopamine (DA)‐containing nerve terminals in the external layer of the median eminence and in the neurointermediate pituitary were determined in rats by a combination of retrograde labeling with wheat germ agglutinin (WGA) and immunohistochemistry for tyrosine hydroxylase (TH) Biotinylated WGA (b‐WGA) was injected into the posterior pituitary (group 1) and into the median eminence (group 2). In group 1 animals, all the magnocellular neurons of the paraventricular, supraoptic, and accessory nuclei, and many parvicellular neurons in the rostral periventricular region (RPR) were labeled with WGA. In group 2 animals, many neurons were labeled in the arcuate nucleus and the RPR, and in a small population of the preoptic‐septal region. In group 1 animals, about 39% of TH neurons in the RPR were labeled with WGA, whereas only a few TH neurons (1%) in the arcuate nucleus were labeled with WGA. In group 2 animals, on the contrary, almost all TH neurons (73%) in the arcuate nucleus carried WGA, whereas in the RPR, only some of the TH neurons (19%) were labeled with WGA. It is concluded that DA neurons involved in the hypothalamic‐anterior pituitary axis are located in the arcuate nucleus; those involved in neuro‐intermediate lobe function in the RPR.
Sex differences in the influence of COMT Val158Met on alcoholism and smoking in plains American Indians.

BACKGROUND Alcoholism and heavy smoking are highly comorbid and are cotransmitted in the general U.S. population; however little is known about comorbidity in American Indians. The catechol-O-methyltransferase (COMT) functional polymorphism, Val158Met, has been associated with alcoholism in Caucasians. The aims of our study were firstly to investigate patterns of alcohol and tobacco consumption and comorbidity between alcoholism and smoking in Plains American Indians and secondly to determine the influence, including sexual dimorphic effects, of COMT Val158Met and COMT haplotypes, on these behaviors. METHODS Diagnostic and Statistical Manual-III-R lifetime diagnoses were assigned to 342 community-ascertained Plains American Indians (201 women, 141 men). Lifetime drinking and smoking histories were obtained. Five COMT loci, including Val158Met, were genotyped. Haplotype-based analyses identified 1 block with 3 common haplotypes; 2 included Val158, and 1 had the Met158 allele. RESULTS The alcoholics drank heavily (12+/-8 drinks/drinking day) but episodically (max 10+/-8 d/mo). Although 62% of male alcoholics and 40% of female alcoholics were smokers (> or =10 cigarettes/d), only 12% of alcoholic men and 8% of alcoholic women smoked heavily (>20/d). In women, the COMT Val158 allele frequency was maximal in alcoholic smokers (0.85), decreasing to 0.74 in nonalcoholic smokers, 0.67 in alcoholic nonsmokers, and 0.64 in nonalcoholic nonsmokers (chi2 = 11.1, 3 df, p = 0.011). Women showed a main effect of Val158 on smoking (p=0.003). Both male and female alcoholics were more likely to have at least 1 Val158 allele compared with nonalcoholics (0.95 vs 0.88, p < 0.05). Approximately 30% of all participants were long-term, nonaddicted light, social smokers (3.6+/-1.7 cigarettes/d); they had the same Val158Met frequencies as nonsmokers. Haplotype analyses supported the Val158Met findings; however, only 1 of the 2 Val158 haplotypes was implicated. CONCLUSIONS Plains Indians have different smoking and drinking patterns and considerably less comorbidity between alcoholism and heavy smoking compared with the general U.S. population. Our COMT Val158Met results suggest that there may be both sex differences in the genetic origins of alcoholism and smoking in this population and overlap in genetic vulnerability to both addictions in women.
An in vitro study to evaluate the accuracy of orthopantomograph as an aid to determine condylar guidance

Purpose: The study was conducted to evaluate the accuracy of orthopantomograph (OPG) as an aid to determine condylar guidance. Methodology: The condylar guidance was measured using the impressions of glenoid fossae and radiographs (OPG) on thirty dried human skulls. Frankfurt horizontal plane (FHP) was used as a reference plane in both the methods and wire markers were adapted to make the contours of glenoid fossae discernible for both the methods. The condylar inclination angle was measured between FHP and a line joining the most concave point on the glenoid fossa with the most inferior point on the articular eminence on both right and left sides. Results: Pearson correlation was used for statistical analysis, and it showed a strong correlation between anatomic and radiographic methods (r = 0.864 for the left side, r = 0.873 for the right side) as well as between right and left sides (r = 0.830). The data were also subjected to regression analysis (linear and panel estimation approach) which showed that OPG could be effectively used to predict the condylar guidance (r2 = 0.6160). Conclusion: Although OPG shows a higher value than anatomic method, it can be used as an aid to set condylar guidance on semi-adjustable articulator.
Regenerative medicine bioprocessing: Concentration and behavior of adherent cell suspensions and pastes

Regenerative medicines based on human cells demand their harvesting, culture, and processing. Manufacturing processes are likely to include cell concentration and subsequent controlled dosing of concentrates, for example, to the patient or tissue construct. The integrity and functionality of the cells must be maintained during these processing stages. In this study the performance of two different cell concentration protocols (involving centrifugation and resuspension) are compared and consideration given to possible causes of cell loss. Further studies examine cell size and rheological behavior of anchorage‐dependent mammalian cell suspensions, and the effect of capillary flow stress (0.5–15 Pa, laminar flow regime) on cell number and membrane integrity as quantified by flow cytometry. The cell concentration protocols achieved maximum cell volume fraction of around 0.3 and the improved protocol exhibited intact cell yield of 80 ± 13%, demonstrating proof‐of principle for achieving tissue‐like cell concentrations by a process of centrifugation and orbital shaking. Volume mean cell diameter (cell diameter at the mean cell volume) for the rat aortic smooth muscle cells (CRL‐1444) used in this study was 22.4 µm. Concentrated cell suspension rheology approximated to power law behavior and exhibited similar trends to reports for plant and yeast cells. Capillary transfer at 2–15 Pa (wall shear stress) did not significantly affect cell number or membrane integrity while losses observed at low shear (0.5, 1.0 Pa) were probably due to surface attachment of cells in the apparatus. Biotechnol. Bioeng. 2009;103: 1236–1247. © 2009 Wiley Periodicals, Inc.
[Cardiac insufficiency in the African cardiology milieu].

OBJECTIVE The aim of this study is to determine the frequency, the aetiologies and the hospital mortality of heart failure in African developing countries. METHODS A prospective study rolled over six months in African urban hospital including 170 patients, middle age 50 years old suffering from heart failure. They underwent clinical, paraclinical cardiac examination. RESULTS Heart failure represented 37.7%. Main cardiac failure risks were: hypertension: 76 cases (45%), diabetes mellitus: 20 cases (11.8%). General heart failure is noted at the entrance in 67.6% with cerebral attack in 5%. EKG showed left ventricle hypertrophy in 108 patients (63.5%) and atrial fibrillation in 28 patients (16.6%). Valvular heart diseases and hypertension are the main aetiologies respectively: 76 cases (45%) and 58 cases (34%). In 10 cases (6%) the aetiology is unspecified. Hospital mortality concerned 44 patients (25.9%). CONCLUSION Heart failure is grave and frequent in developing countries where there is no cardiac surgery. Prevention is possible: fighting against articular rheumatism and control hypertension.
Physical Abuse Leading to Renal Failure

Child physical abuse is a major cause of emergency department visits, admissions, and even deaths in the United States. The estimates of the incidence of physical abuse vary widely because of potential underreporting, as child abuse is often not recognized or misdiagnosed. In 2011, per the US Department of Health and Human Services statistics, there were 676 569 reported victims of child abuse and neglect, making the victim rate approximately 9.1 per 1000 children in the population. The types of injuries acquired during physical abuse may include bruising, bite marks, burns, intracranial injuries, abdominal trauma, and skeletal fractures. There have been previous studies documenting an association between physical abuse involving multiple soft tissue injuries and rhabdomyolysis, a clinical syndrome resulting from the disruption of muscle fibers, causing the release of intracellular muscle contents into the circulation. The typical presentation includes muscle aches, weakness, dark or red urine because of the release of myoglobin and elevated serum muscle enzymes (creatine phosphokinase [CPK]). In the most severe cases, rhabdomyolysis may cause electrolyte abnormalities or renal failure. To our knowledge, there are no reported cases from the US medical literature of abuse-related rhabdomyolysis that required dialysis. There is one report from Saudi Arabia of rhabdomyolysis related to child abuse, which required peritoneal dialysis.
Fentanyl, Esmolol, and Clonidine Blunt the Transient Cardiovascular Stimulation Induced by Desflurane in Humans

Background:A rapid increase In the end-tidal concentration of desflurane to greater than 1 MAC transiently increases heart rate, arterial blood pressure, and circulating epinephrine and vasopressin concentrations. We hypothesized that drugs that block sympathetic activity or decrease sympathetic outflow (an oploid, a β-adrenergic antagonist, and an α2-adrenergic agonist) would blunt these responses. Methods:After induction of anesthesia with intravenous propofol 2 mg/kg in ten healthy male volunteers age 25 ± 1 yr (mean ± standard error), anesthesia was maintained with 4% end-tidal desflurane in oxygen (0.55 MAC) via an endotracheal tube for 32 min. Controlled ventilation provided normocapnia. We then increased the end-tidal desflurane concentration within 1 min to 8% (1.1 MAC) and maintained this concentration for 10 min. On separate days, five of these volunteers were similarly anesthetized except that 5 min before the increase to 8% desflurane, we administered intravenous fentanyl 1.5 µg/kg and on another day 4.5 µg/kg (dose randomly assigned). On 2 separate days, intravenous esmolol 0.75 mg/kg was given to five volunteers 1.5 min before, or clonidine 4.3 µg/kg by mouth to four volunteers 90 min before, the increase from 4% to 8% desflurane. Results:Without pretreatment, the increase to 8% desflurane increased heart rate (from 57 ± 2 to 118 ± 6 beats/ min at peak, mean ± standard error) and mean arterial blood pressure (from 66 ± 2 to 118 ± 5 mmHg). At the time of peak hemodynamic changes (within 1-2 min of the increase in desflurane concentration), plasma epinephrine and norepinephrine concentrations increased (from 22 ± 6 to 339 ± 83 pg/ml and from 205 ± 19 to 283 ± 30 pg/ml, respectively). Fentanyl 1.5 and 4.5 µg/kg attenuated the heart rate increase by 61 ± 14% and 70 ± 7% and the mean arterial blood pressure Increase by 31 ± 16% and 46 ± 11% but did not alter the epinephrine or norepinephrine response at the time of peak cardiovascular changes. Esmolol attenuated the heart rate response but no other response. Clonidine attenuated all responses except that of norepinephrine and also caused postanesthesia sedation. Conclusions:Fentanyl, esmolol, and clonidine blunt the transient cardiovascular response to a rapid increase in desflurane concentration. Fentanyl may be the most clinically useful of these drugs because it blunts the increase in heart rate and blood pressure, has minimal cardiovascular depressant effects, and imposes little postanesthetlc sedation.
Circulating endothelial cells in vascular disorders: new insights into an old concept

Abstract: The endothelial contribution to vascular disorders has been widely documented in experimental models. However, its implication in human pathology is difficult to investigate, owing to the paucity of non‐invasive methods and of specific endothelial markers. The enumeration of circulating endothelial cells (CEC) released in peripheral blood after vascular injury represents a direct exploration of the endothelium. For this purpose, we have produced a monoclonal antibody (S‐Endo 1), which recognizes CD 146, a molecule expressed on all types of human endothelial cells but absent from haemopoietic cells. Using this antibody, we have designed a specific and sensitive immunocapture test, which allowed us to detect high numbers of CEC in thrombotic, infectious or immunological disorders, while CEC were found to be very rare (<3/ml) in normal subjects. This quantitative approach using CEC might prove useful as a marker of vascular wall injury. Their enumeration is of interest in the clinical follow‐up of vascular disorders, in the evaluation of therapeutic effectiveness or in the direct diagnosis of infectious diseases involving intra‐endothelial microbial agents. Furthermore, an immunological and/or functional study of CEC could allow one to assess their procoagulant and proadhesive properties, as well as their viability, opening new perspectives for CEC investigation in vascular pathology.
New Enaliarctos (Pinnipedimorpha) from the Oligocene and Miocene of Oregon and the role of "Enaliarctids" in Pinniped phylogeny

Berta, Annalisa. New Enaliarctos* (Pinnipedimorpha) from the Oligocene and Miocene of Oregon and the Role of "Enaliarctids" in Pinniped Phylogeny. Smithsonian Contributions to Paleobiology, number 69, 33 pages, 22 figures, 1991. —Three new species of the pinnipedimorph Enaliarctos* are described from the marine late Oligocene and early Miocene (Arikareean and Hemingfordian or early Barstovian correlatives) of coastal Oregon. Enaliarctos tedfordl, new species, is based on a partial cranium from the late Oligocene Yaquina Fonnation. A related new species, Enaliarctos emlongi, is founded on a nearly complete cranium, jaws, and associated skeletal elements from the late Oligocene to early Miocene Nye Mudstone. A third new species, Enaliarctos barnesi, is based on a partial cranium and jaws from late Oligocene or early Miocene rocks near the contact between the Yaquina Formation and the Nye Mudstone. Another skull, from the Nye Mudstone, is referred to a previously described species, Enaliarctos mitchelli Barnes, 1979. Three of these species, E. mitchelli, E. emlongi, and E. tedfordl form a monophyletic clade, united by reduced cheek teeth cingula and short metacone of the upper camassial. The major trend observed in Enaliarctos over 10 million years of history is an intermediate stage in the transformation to homodonty evidenced by premolarization of the upper camassial and molars and reduction and simplification of cusps on the lower camassial. Cladistic analysis of 52 cranial and dental characters suggests the following phylogenetic hypotheses: (1) the subfamily "Enaliarctinae" (= "Enaliarctidae") is paraphyletic, (2) monophyly of the genus Enaliarctos* is questioned although the status of this taxon as sister taxon to other pinnipeds is affirmed, (3) other "enaliarctid" pinnipeds, Pteronarctos and Plnnarctidlon, are assigned to less inclusive pinniped clades {Pteronarctos -Iall other pinnipeds and Pinnarctidion + Desmatophoca, Allodesmus, and the Phocidae). OFFICIAL PUBLICATION DATE is handstamped in a limited number of initial copies and is recorded in the Institution's annual report, Smithsonian Year. SERIES COVER DESIGN: The trilobite Phacops rana Green. Library of Congress Cataloging-in-Publication Data Berta, Annalisa New Enaliarctos* (Pinnipedimorpha) from the Oligocene and Miocene of Oregon and the role of "Enaliarctids" in Pinniped phylogeny / Annalisa Berta. p. cm. —(Smithsonian contributions to paleobiology ; no. 69) Includes bibliographical references. 1. Enaliarctos. 2. Paleontology—Oligocene. 3. Paleontology—Miocene 4. Paleontology—Oregon. I. Title. II. Series. QE701.S56 no. 69 [Qe882.P51 560 s-dc20 [569'. 74] 91-18125 © The paper used in this publication meets the minimum requirements of the American National Standard for Permanence of Paper for Printed Library Materials Z39.48—1984.
Electrophysiological characterization of vagal afferents relevant to mucosal nociception in the rat upper oesophagus

Emerging evidence indicates a nociceptive role of vagal afferents. A distinct oesophageal innervation in the rat, with muscular and mucosal afferents travelling predominantly in the recurrent (RLN) and superior laryngeal nerve (SLN), respectively, enabled characterization of mucosal afferents with nociceptive properties, using novel isolated oesophagus–nerve preparations. SLN and RLN single‐fibre recordings identified 55 and 14 units, respectively, with none conducting faster than 8.7 m s−1. Mucosal response characteristics in the SLN distinguished mechanosensors (n= 13), mechanosensors with heat sensitivity (18) from those with cold sensitivity (19) and a mechanoinsensitive group (5). The mechanosensitive fibres, all slowly adapting, showed a unimodal distribution of mechanical thresholds (1.4–128 mN, peak ∼5.7 mN). No difference in response characteristics of C and Aδ fibres was encountered. Mucosal proton stimulation (pH 5.4 for 3 min), mimicking gastro‐oesophageal reflux disease (GORD), revealed in 31% of units a desensitizing response that peaked around 20 s and faded within 60 s. Cold stimulation (15°C) was proportionally encoded but the response showed slow adaptation. In contrast, the noxious heat (48°C) response showed no obvious adaptation with discharge rates reflecting the temperature's time course. Polymodal (69%) mucosal units, > 30% proton sensitive, were found in each fibre category and were considered nociceptors; they are tentatively attributed to vagal nerve endings type I, IV and V, previously morphologically described. All receptive fields were mapped and the distribution indicates that the posterior upper oesophagus may serve as a ‘cutbank’, detecting noxious matters, ingested or regurgitated, and triggering nocifensive reflexes such as bronchoconstriction in GORD.
Association of angiotensinogen (M235T) gene polymorphism with blood pressure lowering response to angiotensin converting enzyme inhibitor (Enalapril).

PURPOSE It has been suggested that genetic backgrounds, which have an association with essential hypertension, may also determine the responsiveness to ACE inhibitor. We determined the association of angiotensinogen (M235T) gene polymorphism with essential hypertension and the relationship between polymorphism in the angiotensinogen (M235T) gene and blood pressure response to ACE inhibitor (Enalapril) in patients with essential hypertension from northern Indian subjects. METHODS 250 patients with essential hypertension and 250 normal healthy controls from Delhi and surrounding areas were recruited for the investigation. Blood pressure was recorded before and after 6 weeks of treatment with ACE inhibitors, Enalapril. Genotyping were carried out by polymerase chain reaction and Restriction fragment length polymorphism technique. RESULTS Statistically significant association of T allele was observed with essential hypertension [x2 = 14.67, p = 0.00013, Odds ratio = 1.76 (1.3-2.32) at 95% CI], the relative risk at 95% CI being 1.28 (1.2-1.54). The decrease in systolic blood pressure and diastolic blood pressure after six weeks of treatment of the patients carrying TT genotype (SBP = 26 ± 17.4 mmHg, DBP = 14.83 ± 7.6 mmHg) were greater than the groups carrying MT (SBP = 3.0 ± 7.8 mmHg, DBP = 6.2 ± 3.0 mmHg) and MM genotypes (SBP = 1.2 ± 0.8 mmHg, DBP = 0.10 ± 12.1 mm Hg. CONCLUSIONS The angiotensinogen (M235T) gene polymorphism is significantly associated with essential hypertension. Patients carrying TT genotype had higher blood pressure lowering response when treated with ACE inhibitor, Enalapril than those carrying MM and MT genotypes suggesting that the T allele may be a possible genetic marker for essential hypertension.
Technique of anti-multi-range-false-target jamming for radar network based on double discrimination

Aiming at active multi-range-false-target deception jamming discrimination of radar network, a technique based on double discrimination of active multi-range-false-target deception jamming of radar network is proposed. Firstly, the benchmark radar is selected, target measurements from the benchmark radar are classified into groups, and the angle measurements in the same group are compressed for improving the measurement accuracy. Then, bearings only measurements association test is used for determining whether the measurements in the radar network are in the direction of the benchmark radar. Measurements passing the bearings only measurements association test will be taken the nearest neighbor association test with measurements in the classified groups of the benchmark radar. At last, the true-targets will be discriminated by double discrimination. The simulation results show that the algorithm can not only improve the correct discrimination rate comparing with the existing method but also track targets stably under the active multi-range-false-target deception jamming.