Miracle-dz/UniFAR-FTUs huggingface dataset:
Amino acid digestibility and nitrogen utilization of high oil , high lysine , and waxy maize fed to growing pigs

Two experiments were conducted to determine the amino acid (AA) digestibility and nitrogen (N) utilization of three maize hybrids, i.e. high oil (HO), waxy (WX), and high lysine (HL) as compared to isogenic high oil (IHO), isogenic waxy (IWX), and a yellow dent (YD1) maize variety near-isogenic to HL. One yellow dent maize of unrelated genetics (YD2) was included as an additional control and to serve as a common treatment for cross-square comparison. In exp. 1, four castrates (initial BW: 52 .8 ± 1.7 kg) were equipped with T-cannulas in the distal ileum and used in two consecutive 4× 4 Latin squares to determine AA digestibility. In exp. 2, eight castrates (initial BW: 19.11± 0.49 kg) were arranged in two 4 × 4 Latin squares and used in a N balance experiment. Diets consisted of 966.2 g test maize/kg and 33.8 g vitamins, minerals, and salt/kg. In exp.1, apparent ileal digestibility coefficients (CAID) for HO and WX were not different ( P > 0.05) compared to their respective isogenic maize or YD2. High lysine maize had lower ( P < 0.05) CAID for isoleucine, leucine, methionine, phenylalanine, threonine, and valine when compared to YD1, its near-isogenic maize, and lower ( P < 0.05) CAID for isoleucine, leucine, and phenylalanine when compared to YD2. Mean CAID for HO, WX, HL, and YD2 were 0 . 65±0.05, 0.70±0.05, 0.53±0.05, and 0.60± 0.03, respectively. True ileal digestibility coefficients (CTID) for the indispensable AA did not differ when HO and WX maize were compared to their respective isogenic maize, but HL maize had lower ( P < 0.05) CTID for the majority of indispensable AA except for arginine and histidine than YD1. Mean CTID for HO, WX, HL, and YD2 were 0 . 78± 0.04, 0.84± 0.04, 0.67± 0.04, and 0.77± 0.03, respectively. Nitrogen retained, urinary N, fecal N, N digestibility, and N utilization for HO, WX, and HL were not different ( P > 0.05) compared to their genetically similar maize. Nitrogen absorbed and DM digestibility were higher ( P < 0.05) for HO than for IHO. Nitrogen digestibility was similar ( P > 0.05) for WX compared to YD 2 and greater ( P > 0.05) for HO and HL compared to YD 2. In conclusion, AA CAID and CTID, were similar for HO and ∗ Corresponding author. Tel. : +1-517-432-5140; fax: +1-517-432-0190. E-mail address: trottier@msu.edu (N.L. Trottier). 1 Present address: 286 ASL, 1207 W. Gregory, University of Illinois, Urbana, IL 61801, USA. 0377-8401/$ – see front matter © 2003 Elsevier B.V. All rights reserved. doi:10.1016/j.anifeedsci. 2003.09. 006 114 J.L. Snow et al. / Animal Feed Science and Technology 113 (2004) 113–126 WX maize compared to their isogenic maize, however, AA CAID and CTID for HL maize was lower than its near-isogenic maize. Nitrogen utilization for HO, WX, and HL were similar to that of their respective genetically similar maize. © 2003 Elsevier B.V. All rights reserved.
Garment needs of pregnant women based on content analysis of in-depth interviews.

AIMS This study aims to identify the needs, concerns and problems of pregnant women when using maternity support garments. BACKGROUND Maternity support belt is regarded as helpful in reducing low back pain during pregnancy. However, several garment-related problems exist which might lead to poor adherence behaviour undermining the benefit of garment therapy. DESIGN A qualitative exploratory study. METHODS. Semi-structured interviews were conducted with 10 pregnant Chinese women who experienced low back pain during pregnancy. All the interviews followed an interview guide and different maternity support garments were shown to the participants as a method of tangible objects to stimulate responses. Content analysis was used to analyse the data. RESULTS The results showed that 60% of pregnant women discontinued using maternity support garments due to excessive heat, perceived ineffectiveness, itchiness, excessive pressure around the abdomen and inconvenience of adjustment. The content analysis generated five main themes of needs including effective function, safety, skin comfort, ease to put on and take off and aesthetics of maternity support garments. DISCUSSION The findings of the five main themes of needs were largely consistent with previous studies examining medical garments for overall satisfaction and compliance. The results revealed that women's physiological and psychological changes during pregnancy influenced their clothing preferences on both functional and aesthetical values. CONCLUSIONS Maternity support garments are convenient and easily-accessible therapy to manage LBP during pregnancy and are frequently recommended and worn by pregnant women. However, inappropriate choice of garment therapy not only led to ineffectiveness but also undesirable effects. The key findings of the five main themes of garment needs in pregnant women will facilitate healthcare professionals in providing evidence-based advice to assist patients in the selection of an appropriate and optimal maternity support garment. RELEVANCE TO CLINICAL PRACTICE These recommendations in the clinical practice will assist patients in making well informed treatment decisions and ultimately improve the quality of care.
Marked increase in beta-tubulin mRNA expression during regeneration of axotomized retinal ganglion cells in adult mammals

Changes in gene expression were investigated in axotomized CNS neurons under conditions that inhibit or permit regrowth of their damaged axons. Levels of mRNA encoding beta-tubulin, the 150 kDa neurofilament subunit (NF-M), and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) were examined by quantitative in situ hybridization of adult rat retinal ganglion cells (RGCs) after axotomy in the optic nerve or during regeneration in a peripheral nerve (PN) graft. Soon after optic nerve section beta-tubulin, NF-M, and GAPDH mRNA levels decreased and remained low during the 1 month studied. In these retinas beta-tubulin mRNA fell to approximately 50% of normal controls. However, in the PN- grafted retinas, where approximately 20% of the surviving axotomized RGCs regenerate their axons, there were “hot spots” of beta-tubulin mRNAs where neuronal levels were nearly 300% higher than in controls. By retrograde neuronal labeling these hot spots were shown to correspond to the injured RGCs that regrew their axons into the PN graft; beta-tubulin mRNA levels in nonregenerating RGCs of the same retinas averaged 63% of controls. We suggest that interactions of RBC axons and components of the grafts' non-neuronal environment play a key role in the over fourfold differences in beta-tubulin mRNA levels observed between injured and regenerating RGCs.
Pigment Epithelium-derived Factor Inhibits Vascular Endothelial Growth Factor-induced Vascular Hyperpermeability Both In Vitro and In Vivo

Administration of pigment epithelium-derived factor (PEDF) inhibits advanced glycation end products-elicited retinal vascular hyperpermeability, as well as cold injury-induced brain oedema in rats. However, the underlying molecular mechanism by which PEDF blocks the hyperpermeability in vivo is not fully understood. This study investigated whether PEDF could inhibit vascular endothelial growth factor (VEGF)-induced vascular hyperpermeability both in vitro and in vivo. The Miles assay revealed that, after intradermal injection of VEGF in nude mice, simultaneous administration of PEDF inhibited vascular hyperpermeability in a dose-dependent manner. The in vitro permeability assay also showed that PEDF blocked the VEGF-induced barrier dysfunction in endothelial cells. These results demonstrated that PEDF could inhibit the VEGF-induced vascular hyperpermeability both in vitro and in vivo, and suggest that PEGF may be suitable to be considered as a novel therapeutic agent for various vasopermeable disorders in which VEGF is involved.
Greek College Students and Psychopathology: New Insights

Background: College students’ mental health problems include depression, anxiety, panic disorders, phobias and obsessive compulsive thoughts. Aims: To investigate Greek college students’ psychopathology. Methods: During the initial evaluation, 638 college students were assessed through the following psychometric questionnaires: (a) Eysenck Personality Questionnaire (EPQ); (b) The Symptom Checklist-90 (SCL-90); (c) The Beck Depression Inventory (BDI); (d) State-Trait Anxiety Inventory (STAI). Results: State anxiety and trait anxiety were correlated, to a statistically significant degree, with the family status of the students (p = 0.024) and the past visits to the psychiatrist (p = 0.039) respectively. The subscale of psychoticism is significantly related with the students’ origin, school, family status and semester. The subscale of neuroticism is significantly related with the students’ school. The subscale of extraversion is significantly related with the students’ family psychiatric history. Students, whose place of origin is Attica, have on average higher scores in somatization, phobic anxiety and paranoid ideation than the other students. Students from abroad have, on average, higher scores in interpersonal sensitivity and psychoticism than students who hail from other parts of Greece. The majority of the students (79.7%) do not suffer from depression, according to the Beck’s depression inventory scale. Conclusions: Anxiety, somatization, personality traits and depression are related with the students’ college life.
Unique aspects of caring for dying children and their families

Pediatric hospice has become an important service for children and their families in the past decade. In this article we present unique aspects of StarShine, the hospice of Children’s Hospital Medical Center in Cincinnati, Ohio. Length-of-service data demonstrate the need to find innovative ways of encouraging earlier referral to hospice. Several specialized aspects of care, such as long-term bereavement, pet visitation and social services for the family are presented. The initiation of a novel in-home pain management program is described. StarShine has not followed an adult hospice model, and as such, we discuss those unique aspects of dying pediatric patients and suggest specific solutions and interventions designed for children.
Some New Exact van der Waerden numbers

For positive integers $r,k_0,k_1,. ,k_{r-1},$ the van der Waerden number $w(k_0,k_1,.,k_{r-1})$ is the least positive integer $n$ such that whenever $\{1,2,. ,n\}$ is partitioned into $r$ sets $S_{0},S_{1},. ,S_{r-1}$, there is some $i$ so that $S_i$ contains a $k_i$-term arithmetic progression. We find several new exact values of $w(k_0,k_1,.,k_{r-1})$. In addition, for the situation in which only one value of $k_i$ differs from 2, we give a precise formula for the van der Waerden function (provided this one value of $k_i$ is not too small)
A 100mW Dual-Band CMOS Mobile-TV Tuner IC for T-DMB/DAB and ISDB-T

A 0.18mum CMOS dual-band low-IF mobile-TV tuner IC for T-DMB/DAB that supports Band-III and L-band is presented. By modifying a few metals and via masks, the IC can support VHF and UHF bands for ISDB-T partial reception. The chip meets all the specifications of both applications with a sensitivity of <-98dBm while consuming 100 mW from a 1.8V supply and occupying 3.4times3. 3mm2
Why Children of College Graduates Outperform Their Schoolmates: A Study of Cousins and Adoptees

Massive cross-sectional evidence exists indicating that children of more educated parents outperform their schoolmates. However, evidence for causal interpretation of this association is weak. We examine a causal relationship using two approaches for identification within the same data: cousins with twin parents and adopted children. We find no effect of mothers' education on children's school performance using the children-of-twins approach. However, for adopted children, mother's education has a small positive effect. Tracking the work experience of parents during offspring childhood, we find no support that this effect can be explained by a higher labor force participation among more educated mothers.
Statistical analysis of agronomical factors and weather conditions influencing deoxynivalenol levels in oats in Scandinavia

The relationship between weather data and agronomical factors and deoxynivalenol (DON) levels in oats was examined with the aim of developing a predictive model. Data were collected from a total of 674 fields during periods of up to 10 years in Finland, Norway and Sweden, and included DON levels in the harvested oats crop, agronomical factors and weather data. The results show that there was a large regional variation in DON levels, with higher levels in one region in Norway compared with other regions in Norway, Finland and Sweden. In this region the median DON level was 1000 ng g–1 and the regulatory limit for human consumption (1750 ng g–1) was exceeded in 28% of the samples. In other regions the median DON levels ranged from 75 to 270 ng g–1, and DON levels exceeded 1750 ng g–1 in 3–8% of the samples. Including more variables than region in a multiple regression model only increased the adjusted coefficient of determination from 0.17 to 0.24, indicating that very little of the variation in DON levels could be explained by weather data or agronomical factors. Thus, it was not possible to predict DON levels based on the variables included in this study. Further studies are needed to solve this problem. Apparently the infection and/or growth of DON producing Fusarium species are promoted in certain regions. One possibility may be to study the species distribution of fungal communities and their changes during the oats cultivation period in more detail.
Human herpes virus-8 in human immunodeficiency virus / acquired immunodeficiency syndrome-associated oral Kaposi ’ s sarcoma

Human herpes virus-8 (HHV-8), now called Kaposi’s sarcoma-associated herpes virus (KSHV), as a probable causative agent of Kaposi’s sarcoma (KS) was putforth when it was first detected in KS specimens in 1994. Since then, many investigators have confirmed the association of HHV-8 and human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) associated KS. This study was done to review the original research aimed at assessing the presence of HHV-8 in HIV/AIDSassociated oral KS and other oral lesions.
快速康复外科在肺癌手术中的应用研究

背景与目的 快速康复外科(fast track surgery, FTS)通过减少手术病人生理和心理的创伤应激, 从而达到病人快速康复的目的。 本研究旨在探讨FTS技术在肺癌手术中应用的可行性。 方法 选取80例适合单叶肺叶切除手术治疗的肺癌患者, 随机分为实验组及对照组, 实验组接受FTS方案治疗、对照组接受传统方法治疗。 比较两组术后不同时间的疼痛程度、肺不张发生率、胸腔积液发生率、术后住院时间及住院总费用。 结果 FTS方案组:术后1 h、6 h、12 h、24 h、48 h疼痛VAS评分均明显低于传统治疗组; 肺不张发生率为10. 53%, 胸腔积液发生率为26. 31%, 术后住院时间(4±1)d, 住院总费用(1.56 ±0.76)万元。 对照组:肺不张发生率为33. 33%, 胸腔积液发生率为22. 22%, 术后住院时间(9±1)d, 总费用(2.36 ±0.54)万元。 两组比较:术后疼痛程度(视觉模拟评分)明显低于对照组, 差异有统计学意义(P < 0.01);肺不张发生率(P=0.035), 住院时间(P=0.021)及住院总费用(P=0.024)的组间差异均有统计学意义; 胸腔积液发生率的组间差异无统计学意义(P=0.223)。 结论 FTS方案的应用可有效促进肺癌患者术后的康复, 减少术后并发症发生, 缩短住院时间, 降低住院费用。
Relationships among neighborhood environment, racial discrimination, psychological distress, and preterm birth in African American women.

OBJECTIVES To (a) examine the relationships among objective and perceived indicators of neighborhood environment, racial discrimination, psychological distress, and gestational age at birth; (b) determine if neighborhood environment and racial discrimination predicted psychological distress; (c) determine if neighborhood environment, racial discrimination, and psychological distress predicted preterm birth; and (d) determine if psychological distress mediated the effects of neighborhood environment and racial discrimination on preterm birth. DESIGN Descriptive correlational comparative. SETTING Postpartum unit of a medical center in Chicago. PARTICIPANTS African American women (n(1) = 33 with preterm birth; n(2) = 39 with full-term birth). METHODS Women completed the instruments 24 to 72 hours after birth. Objective measures of the neighborhood were derived using geographic information systems (GIS). RESULTS Women who reported higher levels of perceived social and physical disorder and perceived crime also reported higher levels of psychological distress. Women who reported more experiences of racial discrimination also had higher levels of psychological distress. Objective social disorder and perceived crime predicted psychological distress. Objective physical disorder and psychological distress predicted preterm birth. Psychological distress mediated the effect of objective social disorder and perceived crime on preterm birth. CONCLUSION Women's neighborhood environments and racial discrimination were related to psychological distress, and these factors may increase the risk for preterm birth.
N-Acetyl-D-galactosamine-inhibitable adherence lectin of Entamoeba histolytica. II. Mitogenic activity for human lymphocytes.

A soluble protein preparation from virulent axenic amoebae (strain HM1-IMSS) has been demonstrated to be mitogenic for normal human lymphocytes; mitogenesis was optimal at 100 micrograms/ml when incubation was maintained for five to seven days with monocytes (P less than .001). After gel filtration chromatography mitogenic activity of fractions was associated with N-acetyl-D-galactosamine-inhibitable lectin activity (agglutination of Chinese hamster ovary cells; P less than .001). Lymphocyte proliferation induced by these active fractions was specifically inhibited by asialofetuin (P less than .001), which contains three terminal beta 1-4 linked galactose residues. In four strains of axenic amoebae mitogenic activity of soluble protein preparations correlated with in vitro virulence and lectin activity for Chinese hamster ovary cells. The amoebic N-acetyl-D-galactosamine-inhibitable lectin appears to be responsible for the mitogenic activity of soluble amoebic protein preparations; alteration of cell-mediated immunity by this amoebic moiety could potentiate in vivo virulence of the parasite.
Tutorial on arbitrary and state-dependent sampling

This tutorial, presents basic concepts and recent research directions about sampled-data systems. We focus mainly on the stability of systems with time-varying sampling intervals. Without being exhaustive, which would be neither possible nor useful, we try to give a structural survey of what we think to be the main results and issues in this domain.
Myonuclear domains in muscle adaptation and disease

Adult skeletal muscle fibers are among the few cell types that are truly multinucleated. Recently, evidence has accumulated supporting a role for the modulation of myonuclear number during muscle remodeling in response to injury, adaptation, and disease. These studies have demonstrated that muscle hypertrophy is associated with, and is dependent on, the addition of newly formed myonuclei via the fusion of myogenic cells to the adult myofiber, whereas muscle atrophy and disease appear to be associated with the loss of myonuclei, possibly through apoptotic‐like mechanisms. Moreover, these studies also have demonstrated that myonuclear domain size, i.e., the amount of cytoplasm per myonucleus, is unchanged following the acute phase of hypertrophy but is reduced following atrophy. Together these data demonstrate that modulation of myonuclear number or myonuclear domain size (or both) is a mechanism contributing to the remodeling of adult skeletal muscle in response to alterations in the level of normal neuromuscular activity. © 1999 John Wiley & Sons, Inc. Muscle Nerve 22: 1350–1360, 1999
CLINICAL PRACTICE. Insomnia Disorder.

A 77-year-old overweight woman with hypertension and arthritis reports that she has had trouble sleeping for “as long as I can remember. ” She has taken hypnotic medications nightly for almost 50 years; her medication was recently switched from lorazepam (1 mg), which had been successful, to trazodone (25 mg) by her primary care physician, who was concerned about her use of the former. She spends 9 hours in bed, from 11 p.m. to 8 a.m. She has only occasional difficulty falling asleep, but she awakens two to three times per night to urinate and lies in bed for over an hour at those times, “just worrying. ” How should her case be managed?
High Density Distribution of Endoplasmic Reticulum Proteins and Mitochondria at Specialized Ca2+ Release Sites in Oligodendrocyte Processes*

In oligodendrocyte processes, methacholine-evoked Ca2+ waves propagate via regions of specialized Ca2+ release kinetics (wave amplification sites) at which the amplitude and rate of rise of local Ca2+ signals are markedly higher than in surrounding areas (Simpson, P. B., and Russell, J. T. (1996) J. Biol. Chem. 271, 33493–33501). In the present study we have examined the effects of other phosphoinositide-coupled agonists on Ca2+ in these cells, and the structural specializations underlying regenerative wave amplification sites. Both bradykinin and norepinephrine evoke Ca2+ waves, which initiate at the same loci and propagate through the cell body and multiple processes via identical wave amplification sites. Antibodies against type 2 inositol 1,4,5-trisphosphate receptors (InsP3R2) and calreticulin identify expression of these proteins in oligodendrocyte membranes in Western blots. Immunocytochemistry followed by high resolution fluorescence microscopy revealed that both InsP3R2 and calreticulin are expressed in high intensity patches along processes. Cross-correlation analysis of the profiles of local Ca2+release kinetics during a Ca2+ wave and immunofluorescence for these proteins along cellular processes showed that the domains of high endoplasmic reticulum protein expression correspond closely to wave amplification sites. Staining cells with the mitochondrial dye, MitoTracker®, showed that mitochondria are only found in intimate association with these sites possessing high density endoplasmic reticulum proteins, and they remain in the same locations over relatively long periods of time. It appears, therefore, that multiple specializations are found at domains of elevated Ca2+ release in oligodendrocyte processes, including high levels of calreticulin, InsP3R2 Ca2+ release channels, and mitochondria.
Characterization of publicly available lymphoblastoid cell lines for disease-associated mutations in 11 genes.

Clinical genetic testing laboratories offer tests for >800 conditions (1) and need both positive and negative genetic control materials for proficiency evaluation, quality control, and test development/validation. Few such materials are available(2)(3)(4)(5). Genetic material, generally DNA, can be purified from Epstein–Barr virus (EBV)-transformed lymphocyte cell lines. The resulting preparations closely resemble DNA purified from patient samples and often are appropriate controls for clinical genetic testing applications. The National Institute of General Medical Sciences (NIGMS) Human Genetic Cell Repository(6) and the National Institute on Aging (NIA) Aging Cell Repository(7) house thousands of EBV-transformed cell lines, but mutations have been described in only ∼600 of these. We screened 13 cell lines from the NIGMS Repository for medically important mutations in 11 different genes: CFTR , F5 , F2 , MTHFR , HFE , GJB2 (connexin 26), FMR1 (fragile X), HBA1/HBA2 (α-thalassemia), FGFR3 , HD , and HbS/HbC. Six of the cell lines had previously been shown to carry 1 or more mutations in at least one of these genes, and 7 were derived from apparently healthy individuals with no known mutations. Some cell lines were subsequently developed for use as clinically validated positive controls for molecular genetic testing or were used as negative control materials [see accompanying article by Bernacki et al (8), in this issue]. DNA was extracted according to the Puregene protocol (Gentra Systems, Inc.). Selected mutations were analyzed by standard molecular diagnostic techniques at the Duke Molecular Diagnostics Laboratory and/or at other CLIA-certified clinical testing facilities where indicated. The 11 diseases characterized, the specific mutations analyzed, and the general methods used are listed below. The OMIM numbers (9) are listed in Table 1⇓ . #### Cystic Fibrosis (CFTR; ABCC7). Four tests were used to analyze the CFTR gene: the Roche Linear Array CF-31 (Roche …