Miracle-dz/UniFAR-FTUs huggingface dataset:
Financial Analysis of Aiternative Treatments for Clinical Mastitis Associated with Environmental Pathogens

For two large California dairy herds with twice daily milking, 17I infected quarters of lactating cows with mild clin ical mastitis were randomly assigned to one of three treatment groups. Group A (50 cows) was treated with 62.5 mg of intramammary amoxiciIIin every 12 h for three milkings. Group C (50 cows) was treated with 200 mg of intramammary cephapirin every 12 h for two milkings. Group 0 (71 cows) was treated with 100 U of intramuscular oxytocin every 12 h for three milkings. Clinical cure rates did not differ among treatment groups. The cost per episode of clinical mastitis was higher ($54.47) for group C than for groups A ($38.53) or 0 ($34.88). Group o had a higher incidence of relapse (41%), and a greater percentage of group o cows (65%) experienced an additional mastitic event in the enrolled lactation than did cows in groups A and C. Treat ment had no effect on the mean number of nonsalable milkings (24.7) associated with mastitis in the lactation interval subsequent to enrollment on the trial. Twenty-two percent of the cows accrued more than 30 nonsalable milkings and produced 55% of the total nonsalable milkings associated with mastitis. There was no treatment effect on total milk
Histamine-Induced versus Exercise-Induced Asthma in Young Adults

Objective: The objective of the study was to measure the prevalence of exercise induced asthma among young medical students of Rawalpindi Medical College, Rawalpindi and to compare airway responses to histamine and exercise challenge. Materials & Methods: Ninety-eight medical students from Rawalpindi Medical College, Rawalpindi were selected after obtaining written consent. They were asked to fill up questionnaire before taking history and doing their physical examination. Each subject was put on exercise by cycle ergometer to such an extent that 80-90% of maximum predicted heart rate was obtained and then same exercise was continued for 6-8 minutes or till symptoms of asthma developed. Before and after exercise challenge, lung functions were measured by using vitalograph compact spirometer and percentage fall in these results was calculated. In another 40 medical students, histamine inhalation challenge was given by increasing dilutions of histamine acid phosphate with the help of Boreal Nebulizer and airway responses were measured with the help of a spirometer. Results: The overall prevalence of exercise and histamine induced asthma in young medical students was found to be 39% and 92% respectively. The comparison between percentage fall of forced expiratory volume (FEV1) in first second and peak expiratory flow rate (PEFR) after exercise and after histamine was significant. Conclusion: The present study revealed that overall exercise induced asthma was more common in our subjects as compared to other studies. Moreover, it was also seen that histamine challenge is a more sensitive test as compared to exercise challenge test for detecting latent asthma.
Structural Rearrangements in the Transmembrane Glycoprotein after Receptor Binding

As in many other viruses, the envelope glycoprotein of HIV plays an important role in the life cycle and the biology of the virus. Its strategic location on the outer surface of the virion dictates in large measure the selection of target cells for virus infection. It mediates virus attachment to its receptor{s) and subsequent virus entry through a membrane fusion process. The envelope also represents a major focus for vaccine strategies in that it harbors the targets for neutralizing antibodies as well as domains recognized by other arms of the immune system. Initially synthesized as a single polypeptide precursor (gpl60), the HIV-1 env glycoprotein, like that from other retroviruses, forms oligomeric complexes (Einfeld & Hunter 1988, Earl et al. 1990, Pinter et al. 1989, Schawaller et al. 1989) in the golgi apparatus before it is cleaved by a host ceil protease into two noncovalently associated subunits, gpl 20 and gp41. The gpl20 is the outer surface (SU) glycoprotein and contains the sites necessary for binding the virus to specific target cells. The gp4l transmembrane (TM) glycoprotein contains the structures required for envelope oligomerization, anchoring the envelope complex to the viral membrane, and several domains required for fusion of the viral membrane with the cell membrane (see below). When studied in T-cell lines, the initial stages of infection involve: 1) virus binding to the CD4 receptor through the SU glycoprotein, 2) con formation at changes occurring in both the SU and TM glycoproteins, 3) fusion of the virus and cell membranes, and 4) entry of the virus contents into the cell. Of these, the
Directional structure-tensor-based coherence to detect seismic faults and channels

ABSTRACTSeismic coherence is widely used in seismic interpretation and reservoir characterization to highlight (with low values) faults and stratigraphic features from a seismic image. A coherence image can be computed from the eigenvalues of conventional structure tenors, which are outer products of gradients of a seismic image. I have developed a simple but effective method to improve such a coherence image by using directional structure tensors, which are different from the conventional structure tensors in only two aspects. First, instead of using image gradients with vertical and horizontal derivatives, I use directional derivatives, computed in directions perpendicular and parallel to seismic structures (reflectors), to construct directional structure tensors. With these directional derivatives, lateral seismic discontinuities, especially those subtle stratigraphic features aligned within dipping structures, can be better captured in the structure tensors. Second, instead of applying Gaussian smooth.
Review of the Research on Botnet

The botnet is controlled by an attacker, which is formed by a lot of vulnerable hosts. The botnet is one of the biggest threats on the Internet. The attacker usually uses it to attack, such as: spam, distributed denial of service attacks, fraud and so on. In this paper, we mainly study the control channel of the botnet, including the IRC protocol, the P2P protocol and the HTTP protocol. At the same time, this paper also studies the detection method of the botnet, which includes the host based detection method and the network based detection method.
Correlating the Blood Alcohol Concentration with Outcome after Traumatic Brain Injury: Too Much Is Not a Bad Thing

Although recent evidence suggests a beneficial effect of alcohol for patients with traumatic brain injury (TBI), the level of alcohol that confers the protective effect is unknown. Our objective was to investigate the relationship between admission blood alcohol concentration (BAC) and outcomes in patients with isolated moderate to severe TBI. From 2005 to 2009, the Los Angeles County Trauma Database was queried for all patients ≥14 years of age with isolated moderate to severe TBI and admission serum alcohol levels. Patients were then stratified into four levels based on admission BAC: None (0 mg/dL), low (0-100 mg/dL), moderate (100-230 mg/dL), and high (≥230 mg/dL). Demographics, patient characteristics, and outcomes were compared across levels. In evaluating 3794 patients, the mortality rate decreased with increasing BAC levels (linear trend P < 0.0001). In determining the relationship between BAC and mortality, multivariable logistic regression analysis demonstrated a high BAC level was significantly protective (adjusted odds ratio 0.55; 95% confidence interval: 0.38-0.8; P = 0.002). In the largest study to date, a high (≥230 mg/dL) admission BAC was independently associated with improved survival in patients with isolated moderate to severe TBI. Additional research is warranted to investigate the potential therapeutic implications.
Distributed energy efficient adaptive clustering protocol with data gathering for large scale wireless sensor networks

Hierarchical routing is an efficient way to lower energy consumption within a cluster, performing data aggregation and fusion in order decrease the number of transmitted messages to the BS. In this paper, a novel hierarchical approach called distributed energy efficient adaptive clustering protocol with Data Gathering (DEACP) is proposed for Wireless sensor network. Since nodes in a sensor network have limited energy, prolonging the network lifetime and improving scalability become important. we have proposed (DEACP) approach to reach the following objectives: reduce the overall network energy consumption, balance the energy consumption among the sensors and extend the lifetime of the network, the clustering must be completely distributed, the clustering should be efficient in complexity of message and time, the cluster-heads should be well-distributed across the network, the load balancing should be done well, the clustered WSN should be fully-connected. As a result transmission power of the node is reduce which subsequently reduces the energy consumption of the node. Our proposed work is simulated through Network Simulator (NS-2). We consider the problem of conserving energy in a single node in a wireless sensor network by turning off the node's radio for periods of a fixed time length. While packets may continue to arrive at the node's buffer during the sleep periods, the node cannot transmit them until it wakes up. The objective is to design sleep control laws that minimize the expected value of a cost function representing both energy consumption costs and holding costs for backlogged packets. The network scenario is established by considering 1000 × 1000 area and displaying randomly moving nodes using TCL. The resource reservation is used to decompose the total simulation time of network into smaller time slots depending upon number of nodes in the network using TDMA technique. Simulations show that (DEACP) clusters have good performance characteristics.
A new perspective on V3 phenotype prediction.

The particular coreceptor used by a strain of HIV-1 to enter a host cell is highly indicative of its pathology. HIV-1 coreceptor usage is primarily determined by the amino add sequences of the V3 loop region of the viral envelope glycoprotein. The canonical approach to sequence-based prediction of coreceptor usage was derived via statistical analysis of a less reliable and significantly smaller data set than is presently available. We aimed to produce a superior phenotypic classifier by applying modern machine learning (ML) techniques to the current database of V3 loop sequences with known phenotype. The trained classifiers along with the sequence data are available for public use at the supplementary website: http://genomiac2.ucsd. edu:8080/wetcat/v3.html and http://www.cs. waikato.ac. nz/ml/weka[corrected].
Perforin Expression in Feline Epitheliotropic Cutaneous Lymphoma

Cutaneous lymphomas are uncommon in people and companion animals. The tumors can be broadly categorized into epitheliotropic and nonepitheliotropic forms, which appear to have different biological behaviors. The present case describes a feline cutaneous epitheliotropic lymphoma. Masses in a 9-year-old cat were first identified on the tail. The cat was treated with chemotherapy, but additional skin masses developed on the flank, face, and ears. Local radiation induced transient tumor regression, but eventual dissemination prompted euthanasia 13 months after initial tumor appearance. Granular lymphocytes were consistently detected on blood smears, and histologically, the tumor involved the skin and superficial subcutis. Tumor lymphocytes expressed cluster of differentiation 3 (CD3) and perforin molecules, suggestive of a cytotoxic phenotype. Location, histopathological features, and perforin expression were similar to a distinct entity in human medicine designated primary cutaneous, CD8-positive, epidermotropic, cytotoxic, T-cell lymphoma.
Preparing Elementary Teachers to Instruct Mildly Handicapped Children in Regular Classrooms: A Summer Workshop

Despite the critics, few systematic efforts have been reported which move special education toward the direction of implementing, as lilly (1971) proposed, a "zero reject model. " The primary goal of this model is to insure a place for all children in the mainstream of education once they are enrolled in regular educational programs. Given the appropriateness of the zero reject model, a logical question is how to achieve an interface between regular and special education which would be directed toward keeping mildly handicapped children in regular education programs. The purpose of this article is to describe one procedure for achieving such an interfacean intensive summer workshop for preparing elementary teachers to instruct mildly handicapped children in regular classrooms.
Speech recognition outcomes following bilateral cochlear implantation in adults aged over 50 years old

Abstract Objective: To examine the speech recognition benefit of bilateral cochlear implantation over unilateral implantation in adults aged over 50 years old, and to identify potential predictors of successful bilateral implantation in this group. Design: Retrospective cohort study using data collected during standard clinical practice. Bilateral performance was compared to the unilateral performance with the first and second implanted ear and examined in relation to potential predictive variables. Study sample: Sixty-seven cochlear implant users who received a second implant after the age of 50 years old. Results: Participants obtained significantly greater speech recognition scores with the use of bilateral cochlear implants compared to the use of each individual implant. The score obtained with the first implanted ear was the most reliable predictor of the score obtained with the second and with bilateral implants. Conclusions: Older adults can obtain speech recognition benefits from sequential bilateral cochlear implantation.
Job Shadowing Experiences as a Teaching Tool: A New Twist on a Tried and True Technique

This article reports an innovative twist on the use of the job shadowing experience as a means not only to provide real-world exposure for the student, but also as a way to generate real-time data from the professionals to be utilized as a basis for class discussion. Reaction from both students and professionals has been overwhelmingly positive.
The internet as a labor market matchmaker How effective are online methods of worker recruitment and job search ?

Since the internet’s earliest days, firms and workers have used various online methods to advertise and find jobs. Until recently there has been little evidence that any internet-based tool has had a measurable effect on job search or recruitment outcomes. However, recent studies, and the growing use of social networking as a business tool, suggest workers and firms are at last developing ways to use the internet as an effective matchmaking tool.
Exploring the critical incident technique to encourage reflection during project-based learning

Previous research has reported on the challenge of promoting students' generic reflection during authentic project-based courses. This work explores a teaching intervention based on Flanagan's Critical Incident Technique (CIT) during a project-based software development course. The intervention aims at increasing students' awareness of their own learning and at encouraging reflective practice throughout the project. Students were asked to report on 'incidents' when they experienced learning during the course, and to reflect on the task itself at the end of the course. The present study focuses on how students approached the incident reporting task and how they perceived it. The results indicate that CIT reporting induces reflection on learning and has positive effects on students' awareness of their own professional knowledge. On the other hand, students found it difficult to identify learning and many found the practice to disturb their work flow.
Does Emotional Intelligence Get Affected from Some Biographical Factors- in Special Reference to Trainee Teachers?

Emotions influence all aspects of human interaction. Emotional intelligence involves the ability to perceive accurately, the appraisal and expression of emotions, the ability to assess and / or generate feelings when they facilitate thought; the ability to understand emotions and emotional knowledge and the ability to regulate emotions to promote emotional and intellectual growth. A teacher in the classroom has to make adjustments in teaching strategies according to the nature and scope of curriculum and evaluate the success of teaching in terms of students’ growth. Teaching is an emotional practice. Teachers’ emotional commitments and connections to students energize and articulate everything that teachers do. In this investigation, with the help of Pearson’s correlation quotient, an attempt has to find out the effect of biographical factors i.e. gender, SES, Type of institution on the emotional intelligence. This investigation revealed that gender does not play any role in development of emotional intelligence; also type of institution does not have any effect on emotional intelligence. But socio economic status shows a significant effect on emotional intelligence. With high socio economic status trainee teachers has high emotional intelligence; on other hand with low socio economic status some trainee teachers has low emotional intelligence.
[Associations of Preoperative Platelet-to-lymphocyte Ratio and Derived Neutrophil-to-lymphocyte Ratio with thePrognosis of Gastrointestinal Stromal Tumor].

OBJECTIVES To determine the associations of preoperative platelet-to-lymphocyte ratio (PLR) and derived neutrophil-to-lymphocyte ratio (d-NLR) with the prognosis of gastrointestinal stromal tumor (GIST). METHODS GIST patients with surgical treatment from June 2005 to February 2015 in West China Hospital of Sichuan University were enrolled in the study. The results of blood routine tests of the patients within one week prior to surgery and their clinical data were extracted. The patients were divided into high-PLR/d-NLR (PLR#>153.075, d-NLR#>1.245) and low-PLR/d-NLR (PLR≤153.075, d-NLR≤1.245) groups according to the optimal cutoff values of the receiver operating characteristic (ROC) curves. Recurrence-free survival (RFS) rates were calculated using Kaplan-Meier method. COX regression analyses were performed to identify factors associated with RFS for GIST patients without imatinib treatment. [WTHZ]. RESULTS [WTBZ]Regardless of imatinib treatment, the patients with high PLR and d-NLR had shorter RFS than those with low PLR and d-NLR. Tumor diameter, location, mitotic counts, preoperative PLR and d-NLR were identified as factors associated with RFS in the univariate analyses. The multivariate analysis identified tumor diameter [≥5 cm, hazard ratio (HR): 4.295, 95% confidence interval (CI): 1.772-10.413, P=0.001], non-stomach (HR:2.247, 95%CI: 1.200-4.209; P=0.011), mitotic counts (>5/50 HPF: HR:4.678, 95%CI: 2.364-9.257; P<0.001) and high d-NLR (HR:2.549, 95%CI: 1.159-5.606; P=0.1020) as independent factors predicting the prognosis of GIST. The patients with high PLR or high d-NLR had shorter RFS than those with low PLR/d-NLR. [WTHZ]. CONCLUSION [WTBZ]Preoperative d-NLR is an independent predictor of RFS in GIST. PLR and d-NLR can be used in predicting the recurrence risk of GIST.
Involvement of Importin-4 in the Transport of Transition Protein 2 into the Spermatid Nucleus

ABSTRACT Mammalian spermiogenesis is characterized by a unique chromatin-remodeling process in which histones are replaced by transition protein 1 (TP1), TP2, and TP4, which are further replaced by protamines. We showed previously that the import of TP2 into the haploid spermatid nucleus requires the components of cytosol and ATP. We have now carried out a detailed analysis to characterize the molecular components underlying the nuclear translocation of TP2. Real-time PCR analysis of the expression of different importins in testicular germ cells revealed that importin-4 and importin-β3 are significantly up-regulated in tetraploid and haploid germ cells. We carried out physical interaction studies as well as an in vitro nuclear transport assay using recombinant TP2 and the nuclear localization signal of TP2 (TP2NLS) fused to glutathione S-transferase in digitonin-permeabilized, haploid, round spermatids and identified importin-4 to be involved in the import of TP2. A three-dimensional model of the importin-4 protein was generated using the crystal structure of importin-β1 as the template. Molecular docking simulations of TP2NLS with the importin-4 structure led to the identification of a TP2NLS binding pocket spanning the three helices (helices 21 to 23) of importin-4, which was experimentally confirmed by in vitro interaction and import studies with different deletion mutants of importin-4. In contrast to TP2, TP1 import was accomplished through a passive diffusion process.
Differential Expression of Sialyl and Non-Sialyl-CD15 Antigens on Hodgkin-Reed-Sternberg Cells: Significance in Hodgkin's Disease

CD15 expression has been used for years to confirm the diagnosis of Hodgkin's disease (HD). Little is, however, known on the relevance of the CD15 antigen to the pathobiology of the disease and there is conflicting evidence as to the prognostic value of its expression. To investigate the significance of the differential expression of CD 15 in Hodgkin's disease, a retrospective study of 102 patients with “classical” Hodgkin's disease was performed. Immuno-histochemical studies were carried out using antibodies against two types of CD 15: non-sialylated CD15 (LeuM1 and 80H5) and sialylated CD15 (FH6 and CSLEX1). Cases that were negative for non-sialylated CD 15 or positive for the sialylated variant were stained again following neuraminidase pretreatment. The cohort included 27 patients in whom sequential biopsies were available. Both CD15 expression in its non-sialylated form and absence of sialyl-CD15 expression correlate with a favorable outcome. Subsequent biopsies show a preferential expression of sialyl-CD15, notably in bone marrow metastases. Our findings suggest that, in the progression of HD towards a widely disseminated disease, the LewisX moiety of the CD 15 antigen on the tumor cells acquires a sialyl-group. This change may confer on the tumor cells the capacity to metastasize.
Depression and Anxiety among Parents of Children with Cystic Fibrosis Related to the Children’s Health Related Quality of Life

The aim was to examine depression and anxiety among parents of children with Cystic Fibrosis and the association between the parents’ symptoms and the child’s quality of life as rated by the parents. Parents completed HADS (Hospital Anxiety and Depression Scale), and CES-D (Center of Epidemiologic Studies Depression Scale), and assessed the children’s quality of life with CFQ-R (Cystic Fibrosis Questionnaire-Revised). Anxiety amongst the parents was higher than the general population (m = 6.55, SD = 3.54, p < 0.001). The level of depression does not differ from that of the general population. Mothers showed more anxiety symptoms than fathers (p < 0.001). Gender differences were not significant for depression symptoms. There is a strong association between the fathers’ self-rated depression and their rating of their child’s health. Both children and parents should be paid attention to in order to identify mental ill-health and take measures in good time.