Miracle-dz/UniFAR-FTUs huggingface dataset:
The acute effects of yoga on cognitive measures for women with premenstrual syndrome.

OBJECTIVES Recently, yoga classes specifically for women with premenstrual syndrome (PMS) have increased, but there is little research about the efficacy of these classes. The primary aims of this study were to evaluate the effect of yoga exercise on women with PMS and to evaluate the immediate change of attention performance after yoga classes. METHODS This study examined the attention task results of women with PMS. Eleven women with PMS and 9 women without PMS were recruited. The PMS group took the tests before and immediately after the yoga class both in the luteal and follicular phase of one menstrual cycle, while the control group took the tests only twice: once in the luteal phase and once in the follicular phase. Both groups were required to finish resting electroencephalography (EEG) and cognitive task of the 2-back task with EEG recording. RESULTS The alpha brain wave percentage was higher immediately after yoga exercise in the PMS group. This suggests that the participants felt more relaxed or were in a more peaceful mental condition after yoga exercise. In the 2-back task, the PMS group needed a longer reaction time to respond to the target stimulus in the luteal phase and performed better with higher accuracy and shorter reaction time after yoga exercise. The event-related potentials of the EEG recording displayed a significant variability at the P3 amplitude throughout the menstrual cycle in the PMS group, but the P3 amplitude was unchanged throughout the menstrual cycle in the control group. CONCLUSION The results of this study suggest that women with PMS could attend short-term yoga exercise in the luteal phase to make themselves feel better and maintain a better attention level.
Regulation of Cell Division, Biofilm Formation, and Virulence by FlhC in Escherichia coli O157:H7 Grown on Meat

ABSTRACT To understand the continuous problems that Escherichia coli O157:H7 causes as food pathogen, this study assessed global gene regulation in bacteria growing on meat. Since FlhD/FlhC of E. coli K-12 laboratory strains was previously established as a major control point in transducing signals from the environment to several cellular processes, this study compared the expression pattern of an E. coli O157:H7 parent strain to that of its isogenic flhC mutant. This was done with bacteria that had been grown on meat. Microarray experiments revealed 287 putative targets of FlhC. Real-time PCR was performed as an alternative estimate of transcription and confirmed microarray data for 13 out of 15 genes tested (87%). The confirmed genes are representative of cellular functions, such as central metabolism, cell division, biofilm formation, and pathogenicity. An additional 13 genes from the same cellular functions that had not been hypothesized as being regulated by FlhC by the microarray experiment were tested with real-time PCR and also exhibited higher expression levels in the flhC mutant than in the parent strain. Physiological experiments were performed and confirmed that FlhC reduced the cell division rate, the amount of biofilm biomass, and pathogenicity in a chicken embryo lethality model. Altogether, this study provides valuable insight into the complex regulatory network of the pathogen that enables its survival under various environmental conditions. This information may be used to develop strategies that could be used to reduce the number of cells or pathogenicity of E. coli O157:H7 on meat by interfering with the signal transduction pathways.
Mechanism of Collapse of Endoplasmic Reticulum Cisternae During African Swine Fever Virus Infection

Infection of cells with African swine fever virus (ASFV) can lead to the formation of zipper‐like stacks of structural proteins attached to collapsed endoplasmic reticulum (ER) cisternae. We show that the collapse of ER cisternae observed during ASFV infection is dependent on the viral envelope protein, J13Lp. Expression of J13Lp alone in cells is sufficient to induce collapsed ER cisternae. Collapse was dependent on a cysteine residue in the N‐terminal domain of J13Lp exposed to the ER lumen. Luminal collapse was also dependent on the expression of J13Lp within stacks of ER where antiparallel interactions between the cytoplasmic domains of J13Lp orientated N‐terminal domains across ER cisternae. Cisternal collapse was then driven by disulphide bonds between N‐terminal domains arranged in antiparallel arrays across the ER lumen. This provides a novel mechanism for biogenesis of modified stacks of ER present in cells infected with ASFV, and may also be relevant to cellular processes.
Investigating Invariance in the Factorial Structure of the Anxiety Sensitivity Index Across Adult Men and Women

The Anxiety Sensitivity Index (ASI; Peterson & Reiss, 1992) is one of the most widely used measures of the fear of anxiety-related sensations. Important gender differences also seem to exist in that women report higher levels of anxiety sensitivity than men. The primary objective of this study was to determine whether an equivalent factorial structure exists for the ASI among nonclinical adult men and women. In Study 1 (568 women; 251 men), the 2-factor (Fear of Cardiopulmonary Sensations and Fear of Mental Catastrophe), 10-item version of the ASI reported by Schmidt and Joiner (2002) provided the best fit to the data for both men and women. Using this model, Study 2 (503 women, 255 men) examined whether the factorial structure of the 10-item ASI was invariant for men and women. Noninvariance was found for one item on the Fear of Mental Catastrophe subscale (Item 15 = "When I am nervous, I worry that I might be mentally ill"). The implications of this are that this item should be dropped if an equivalent factor structure is to be assumed between men and women.
Benchmarking the ERG valve tip and MRI Interventions Smart Flow neurocatheter convection-enhanced delivery system's performance in a gel model of the brain: employing infusion protocols proposed for gene therapy for Parkinson's disease

Convection-enhanced delivery (CED) is an advanced infusion technique used to deliver therapeutic agents into the brain. CED has shown promise in recent clinical trials. Independent verification of published parameters is warranted with benchmark testing of published parameters in applicable models such as gel phantoms, ex vivo tissue and in vivo non-human animal models to effectively inform planned and future clinical therapies. In the current study, specific performance characteristics of two CED infusion catheter systems, such as backflow, infusion cloud morphology, volume of distribution (mm3) versus the infused volume (mm3) (Vd/Vi) ratios, rate of infusion (µl min−1) and pressure (mmHg), were examined to ensure published performance standards for the ERG valve-tip (VT) catheter. We tested the hypothesis that the ERG VT catheter with an infusion protocol of a steady 1 µl min−1 functionality is comparable to the newly FDA approved MRI Interventions Smart Flow (SF) catheter with the UCSF infusion protocol in an agarose gel model. In the gel phantom models, no significant difference was found in performance parameters between the VT and SF catheter. We report, for the first time, such benchmark characteristics in CED between these two otherwise similar single-end port VT with stylet and end-port non-stylet infusion systems. Results of the current study in agarose gel models suggest that the performance of the VT catheter is comparable to the SF catheter and warrants further investigation as a tool in the armamentarium of CED techniques for eventual clinical use and application.
Generation of strong optical field in soft X-ray region by using high-order harmonics

For further development of a variety of applications, one of the most important issues is the improvement of output harmonic energy and conversion efficiency. We review our work on the energy scaling of high-order harmonic generation based on phase-matching using a loosely focused beam. Our harmonic energy scaling method can be universally applied to harmonic generation in the neutral rare gas target. In addition, we demonstrate a new concept for spatial separation between the high-energy pump and harmonic beam to increase the available soft X-ray energy for the applications. This method is very simple and highly useful for not only high-order harmonic generation but also longitudinally pumped X-ray lasers. By combining the high-energy high harmonic source and new spatial separation method, we successfully demonstrate focusing of the soft X-ray beam with a peak intensity of 1/spl times/10/sup 14/ W/cm/sup 2/, which is to our knowledge the highest ever reported in the soft X-ray region.
NBS1 and TRF1 Colocalize at Promyelocytic Leukemia Bodies during Late S/G2 Phases in Immortalized Telomerase-negative Cells

Nijmegen breakage syndrome, a chromosomal instability disorder, is characterized in part by cellular hypersensitivity to ionizing radiation. The NBS1gene product, p95 (NBS1 or nibrin) forms a complex with Rad50 and Mre11. Cells deficient in the formation of this complex are defective in DNA double-strand break repair, cell cycle checkpoint control, and telomere length maintenance. How the NBS1 complex is involved in telomere length maintenance remains unclear. Here we show that the C-terminal region of NBS1 interacts directly with a telomere repeat binding factor, TRF1, by both yeast two-hybrid and in vivoDNA-coimmunoprecipitation assays. NBS1 and Mre11 colocalize with TRF1 at promyelocytic leukemia (PML) nuclear bodies in immortalized telomerase-negative cell lines, but rarely in telomerase-positive cell lines. The translocation of NBS1 to PML bodies occurs specifically during late S to G2 phases of the cell cycle and coincides with active DNA synthesis in these NBS1-containing PML bodies. These results suggest that NBS1 may be involved in alternative lengthening of telomeres in telomerase-negative immortalized cells.
Hypergraph clustering with inhomogeneous partitions of hyperedges Pan

The extension of conventional clustering to hypergraph clustering, which involves higher order relations among nodes instead of pairwise relations, is increasingly gaining attention, as multi-node relations may capture more informative clustering structures. One of widely used methodologies for hypergraph clustering is to minimize a normalized sum of the costs to partition hyperedges across clusters. All the approaches along this line were proposed by assuming that different types of partitioning of one hyperedge correspond to one single cost. However, this assumption limits the usage of hypergraph clustering because of the failure to leverage the possible non-uniformity of hyperedges. In this paper, we proposed a hypergraph clustering approach that can handle non-uniform partitioning costs assigned to hyperedges. We first prove that the algorithm can achieve a quadratically approximate solution if the non-uniform costs satisfy some soft conditions. Moreover, we list some applications in ranking data analysis, subspace segmentation and network structure analysis, where, by allowing non-uniform partition of hyperedges, our algorithm outperforms traditional hypergraph clustering methods.
AIS Electronic Library (AISeL)

In the e-commerce environment, a person’s concerns for information privacy (CFIP) regarding the general e-commerce environment are different from his or her specific concerns for information privacy regarding particular web sites. Such a distinction was observed in literature but received limited attention for its clarification. Importantly, how the two types of privacy concerns relate to each other and how they relate to various antecedent and consequence factors were not well studied. Drawing upon attitude theories, this research develops a dichotomy of privacy concerns, including general CFIP and specific CFIP. A research model is developed to specify the relationship between the two constructs and their relationship with antecedent and consequence factors. Potential contributions to research and practice are discussed.
Factors influencing the success of GBR. Smoking, timing of implant placement, implant location, bone quality and provisional restoration.

The aim of this retrospective clinical study was to evaluate the influence of different factors on the outcome of GBR treatment. 75 patients, who were not randomly assigned to the investigated parameters for clinical reasons, were included in the study. They presented with defect sites around implants and were treated with a xenogenic grafting material and a resorbable collagen membrane. The defect morphology was described, its dimension was measured and calculated at the time of implant installation and at re-entry. The success of GBR treatment was related to several clinical variables and possible correlations were evaluated. Defect sites around maxillary implants showed significantly more bone fill (96%) compared to those in the mandible (78%). The insertion of a provisional restoration during the healing period was also associated with significantly better results than when no provisional was inserted. Immediate and short-term delayed implant placements showed the best results both with 92% bone fill, when compared with long-term delayed placements with 80% bone fill (n.s.). In sites with type I bone quality (compact bone), a reduced bone fill was observed (64%). The results indicate that successful bone fill can be achieved with GBR; this is more feasible in the maxilla, when a provisional restoration is used. Early implant placement timings seem to be preferable due to the alveolar ridge preservation, more favorable defect morphologies and a higher regenerative capacity.
Protein phosphatase 2A dephosphorylates simian virus 40 large T antigen specifically at residues involved in regulation of DNA-binding activity

Treatment of purified simian virus 40 large T antigen (LT) with protein phosphatase 2A stimulates LT-dependent DNA unwinding and replication (D. M. Virshup, M. G. Kauffman, and T. J. Kelly, EMBO J. 8: 3891-3898, 1989). The specificity of the catalytic subunit of protein phosphatase 2A toward LT was investigated by two-dimensional peptide mapping. Increasing amounts of phosphatase sequentially removed the phosphates from serine residues 120, 123, 677, and perhaps 679, residues which have been implicated in regulating the DNA-binding activity of LT.
2 Canine Primary Hyperparathyroidism

Canine primary hyperparathyroid­ ism (PHPT) is characterized by ab­ normal parathyroid “chief” cells that function autonomously due to a parathyroid adenoma, a carcinoma, or adenomatous hyperplasia of one or more parathyroid glands. Other forms of hyper­ parathyroidism are usually due to non­ endocrine disturbances in calcium and phosphorous homeostasis that indirectly affect the parathyroid glands, leading to diffuse hyperplasia. In these cases (renal or nutritional secondary hyperparathy­ roidism), the secretion of parathyroid hor­ mone (PTH) is not autonomous but rather a secondary manifestation of disease.
Design Optimization of a Fluxgate Current Sensor With Low Interference

A new fluxgate current sensor is presented in this paper. The sensor consists of an additional magnetic toroidal core and an additional winding, aside from the elements in a traditional sensor. In addition, the exciting winding is wound along the circumference of the toroidal core to decouple the exciting magnetic field and the feedback magnetic field in order to reduce internal interference. With the additional core and the additional winding, the proposed current sensor can extend its bandwidth to medium- and high-frequency ac measurement. Another purpose of introducing the additional core is to concentrate on the exciting magnetic field and to reduce interference from external disturbances. A prototype of the proposed sensor was designed and tested. Test results show that the sensor is less affected by hysteresis effects and has a measurement error (precision) within 0.4% of the full scale, a 40-kHz small-signal bandwidth, remarkable sensitivity, and linearity in the measurement range up to 25 A.
Death Ideas, Suicidal Thoughts, and Plans Among Nursing Home Residents

Recent studies have shown that suicides are at least as frequent among Nursing Home (NH) residents as they are among older people in the general population. The objective of the present study was to evaluate the prevalence of death- and/or suicidal feelings, thoughts, and plans and any attempted suicides in a random, unselected sample (N = 288) of individuals aged 65-years-and-over, living in NHs located in the Veneto Region (the Italian North-East). One hundred seventy-two participants were surveyed with a response rate of 59.7%. Five sample questions were asked to investigate the presence of death- and suicidal thoughts, plans and behaviors in different time periods. Among the NH residents, 30.8% admitted having had death or suicidal thoughts or plans during the month prior to the interview. The oldest-old residents (85 + y) more frequently reported death-suicide ideation. This high frequency of death and/or suicidal feelings and thoughts among older NH residents should be carefully considered when planning and implementing health care programs in these facilities.
Cardiovascular, respiratory, and metabolic changes produced by pressure-supported ventilation in intensive care unit patients.

The cardiovascular, respiratory and metabolic effects of pressure-supported ventilation with 7, 14 and 21 cm H2O were studied in 16 spontaneously breathing patients convalescing from severe illness. No statistically significant changes occurred in the hemodynamic variables, although CVP and urine output were increased at the higher levels of pressure support. Minute volume and blood gases did not change. Pressure-supported ventilation was associated with a statistically significant decrease in respiratory rate (p less than .002), a significant increase in tidal volume (p less than .01) and in mean airway pressure (p less than .001). Oxygen consumption, CO2 production, and resting energy expenditure were reduced by 14% to 20%, 17% to 25% and 10% to 18%, respectively, the decrease being proportional to the level of pressure support. These changes of the metabolic variables were not found to be statistically significant.
Susceptibility of E . coli to Commonly Used Antimicrobials isolated From Urine Samples

Urinary tract infections (UTIs) are among the most common infectious diseases all over the world. Recent studies reported an increased antibiotic resistance in Escherichia coli, primary causative agent of UTI. The resistance has emerged even to more potent antimicrobial agents like fluoroquinolones. Details of 204 urine culture positive reports for E.coli and their antibiotic sensitivity pattern pertaining to the study period of 4 years from Jan 2012 to Dec 2015 were collected from Central Microbiology Laboratory of Tertiary care Hospital and the results were statistically analysed. The sensitivity pattern of E.coli to antibiotics in UTI were Nitrofurantoin (89.68%), Amikacin (88.25%), Co-trimoxazole (27.44%), Gentamycin (49.90%), Ceftazidime (22.5%), Ciprofloxacin (10.78%), Levofloxacin ( 31.85% ) Cefotaxime (15.78%), Cefuroxime (14.21% ), Ceftriaxone (16.17%), Piperacillin-Tazobactum (85.27%). The isolates showed high levels of resistance to Ampicillin, Amoxicillin-Clavulanic Acid, Norfloxacin, Cefuroxime, Ceftriaxone and Cotrimoxazole. The study shows that the organism E.coli in UTI is resistant to commonly prescribed drugs like Quinolones. This resistance was seen more in the in-patients, elderly males and females. The drug Quinolone is commonly prescribed because it achieves high concentration in urine. Over use of Quinolone has led to increased prevalence of E.coli resistance to Quinolones E.coli has developed resistance to third generation Cephalosporins, Quinolones, and cotrimoxazole and so they cannot be considered for empirical treatment in UTI caused by E.coliin this group of population.
Age-related neural activity during allocentric spatial memory

Age-related decline in allocentric (viewer-independent) spatial memory is seen across species. We employed a virtual reality analogue of the Morris Water Maze to study the effect of healthy ageing on neural activity during allocentric spatial memory using functional magnetic resonance imaging. Voxel-based morphometry was used to ascertain hippocampal volumetric integrity. A widespread neural network comprising frontal, parietal, occipital, thalamic, and cerebellar regions was activated in young and older adults, but only young adults significantly activated bilateral hippocampus and left parahippocampus, as well as right frontal pole and dorso-lateral prefrontal cortex (DLPFC) during encoding and right DLPC during retrieval. Hippocampal grey matter volume was unchanged in older adults; however, prefrontal and parahippocampal functional attenuation was accompanied by volumetric reduction. We conclude that the decline in allocentric spatial memory with age is associated with attenuated hippocampal function, as well as compromised function and structure of prefrontal and parahippocampal regions.
Redox reactions and microbial killing in the neutrophil phagosome.

SIGNIFICANCE When neutrophils kill microorganisms, they ingest them into phagosomes and bombard them with a burst of reactive oxygen species. RECENT ADVANCES This review focuses on what oxidants are produced and how they kill. The neutrophil NADPH oxidase is activated and shuttles electrons from NADPH in the cytoplasm to oxygen in the phagosomal lumen. Superoxide is generated in the narrow space between the ingested organism and the phagosomal membrane and kinetic modeling indicates that it reaches a concentration of around 20 μM. Degranulation leads to a very high protein concentration with up to millimolar myeloperoxidase (MPO). MPO has many substrates, but its main phagosomal reactions should be to dismutate superoxide and, provided adequate chloride, catalyze efficient conversion of hydrogen peroxide to hypochlorous acid (HOCl). Studies with specific probes have shown that HOCl is produced in the phagosome and reacts with ingested bacteria. The amount generated should be high enough to kill. However, much of the HOCl reacts with phagosomal proteins. Generation of chloramines may contribute to killing, but the full consequences of this are not yet clear. CRITICAL ISSUES Isolated neutrophils kill most of the ingested microorganisms rapidly by an MPO-dependent mechanism that is almost certainly due to HOCl. However, individuals with MPO deficiency rarely have problems with infection. A possible explanation is that HOCl provides a frontline response that kills most of the microorganisms, with survivors killed by nonoxidative processes. The latter may deal adequately with low-level infection but with high exposure, more efficient HOCl-dependent killing is required. FUTURE DIRECTIONS Better quantification of HOCl and other oxidants in the phagosome should clarify their roles in antimicrobial action.