Miracle-dz/UniFAR-FTUs huggingface dataset:
The Role of Negative Affect and Physiological Regulation in Maternal Attribution

SYNOPSIS Objective. Mothers who attribute child misbehaviors to children’s intentions, and not to situational causes, show more hostile parenting behaviors. Why are some mothers more likely than others to make more hostile attributions (i.e., high intentional attributions and low situational attributions) when confronted with child challenging behaviors? We examined the relation between mothers’ perception of child challenging behaviors and their hostile attributions of child misbehaviors, with an emphasis on how maternal negative affect and resting vagal activity moderated this relation. Design. One hundred sixty mothers of 3- to 7-year-old children reported their perceptions of child problem behaviors, their attributions regarding child misbehaviors, and their temperamental negative affect. Mothers’ respiratory sinus arrhythmia was measured during resting state. Results. Maternal perceptions of child challenging behaviors were positively related to hostile maternal attributions, and this relation was strongest in mothers with high negative affect and low resting RSA. Conclusions. These findings indicate the importance of considering mothers’ affective and physiological attributes when examining social-cognitive processes in parenting.
Sesquiterpene lactone contact sensitivity: clinical patterns of Compositae dermatitis and relationship to chronic actinic dermatitis

A mix of 3 sesquiterpene lactones (SL) (SL mix 0.1%) was evaluated over a 4‐year period, Of 7420 patients with eczema investigated by patch testing. 135 (68 male, 67 female) (1.8%) demonstrated positive reactions, 114 (84%) considered clinically relevant. Females outnumbered males until the age of 60, after which men were more commonly affected. The clinical patterns varied from patients presenting with generalized eczema (20%) or eczema of the hands and face (24%). to patients with hand (36%) or facial eczema (11%) alone. 48 patients were investigated for suspected photosensitivity and 29 (21 male, mean age 69 years, and 8 female, mean age 66 years) had abnormal cutaneous monochromatic irradiation tests. These results highlight the varied clinical presentation of SL contact dermatitis and its association with chronic actinic dermatitis. The SL mix proved reliable and safe, supporting its inclusion in the European standard series of contact allergens.
Phylogenie des pseudoboini et evolution des xenodontinae sud-americains (serpentes, colubridae)

Cette these fourni un historique des taxons supra-generiques relatifs a l'assemblage de xenodontines sud-americains. L'analyse et description de caracteres hemipeniens et de certains caracteres myologiques, visceraux et glandulaires a permis de definir un groupe monophyletique de xenodontinae sensu stricto, ainsi que plusieurs sous-unites au sein de ce groupe, comportant un total de 41 genres. La definition d'une unite monophyletique de xenodontinae nous a permis de proposer une hypothese phylogenetique pour les sous-unites. Cette hypothese est representee par le consensus strict de 155 arbres d'egale parcimonie (longueur 47, ci 0. 73), ou la sequence des groupes externes aux pseudoboini est postulee. Les pseudoboini ont, pour leur part, ete clairement definis par 10 synapomorphies. La matrice de caracteres des pseudoboini comporte 54 transformations distribuees sur 46 caracteres. L'analyse de parcimonie de la matrice de caracteres a fournis deux arbres d'egale parcimonie (longueur 70, ci 0. 75). Une nouvelle nomenclature generique est proposee pour les pseudoboini, qui reflete leur relation de parente. Les changements taxinomiques les plus importants correspondent a la necessite de creer trois nouveaux genres et de synonymiser deux autres
The sequence specificity domain of cytosine-C5 methylases.

Prokaryotic DNA[cytosine-C5]methyltransferases (m5C-methylases) share a common architectural arrangement of ten conserved sequence motifs. A series of eleven hybrids have been constructed between the HpaII (recognition sequence: Cm5CGG) and HhaI (recognition sequence: Gm5CGC) DNA-methylases. The hybrids were over-expressed in E.coli and their in vivo methylation phenotypes investigated. Six were inactive by our assay while five of them retained partial methylation activity and full specificity. In all five cases the specificity matched that of the parent methylase which contributed the so-called variable region, located between conserved motifs VIII and IX. This was the only sequence held in common between the active hybrids and for the first time provides unequivocal evidence that the specificity determinants of the mono-specific m5C-methylases are located within the variable region. Correlation of the hybrid methylase structure with the efficiency of methylation suggests that conserved motif IX may interact with the variable region whereas motif X most probably interacts with the N-terminal half of the molecule.
Decline in infection-related morbidities following drug-mediated reductions in the intensity of Schistosoma infection: A systematic review and meta-analysis

Background Since 1984, WHO has endorsed drug treatment to reduce Schistosoma infection and its consequent morbidity. Cross-sectional studies suggest pre-treatment correlation between infection intensity and risk for Schistosoma-related pathology. However, evidence also suggests that post-treatment reduction in intensity may not reverse morbidity because some morbidities occur at all levels of infection, and some reflect permanent tissue damage. The aim of this project was to systematically review evidence on drug-based control of schistosomiasis and to develop a quantitative estimate of the impact of post-treatment reductions in infection intensity on prevalence of infection-associated morbidity. Methodology/Principal findings This review was registered at inception with PROSPERO (CRD42015026080). Studies that evaluated morbidity before and after treatment were identified by online searches and searches of private archives. Post-treatment odds ratios or standardized mean differences were calculated for each outcome, and these were correlated to treatment-related egg count reduction ratios (ERRs) by meta-regression. A greater ERR correlated with greater reduction in odds of most morbidities. Random effects meta-analysis was used to derive summary estimates: after treatment of S. mansoni and S. japonicum, left-sided hepatomegaly was reduced by 54%, right-sided hepatomegaly by 47%, splenomegaly by 37%, periportal fibrosis by 52%, diarrhea by 53%, and blood in stools by 75%. For S. haematobium, hematuria was reduced by 92%, proteinuria by 90%, bladder lesions by 86%, and upper urinary tract lesions by 72%. There were no consistent changes in portal dilation or hemoglobin levels. In sub-group analysis, age, infection status, region, parasite species, and interval to follow-up were associated with meaningful differences in outcome. Conclusion/Significance While there are challenges to implementing therapy for schistosomiasis, and praziquantel therapy is not fully curative, reductions in egg output are significantly correlated with decreased morbidity and can be used to project diminution in disease burden when contemplating more aggressive strategies to minimize infection intensity.
Cosmeceuticals: peptides, proteins, and growth factors

Recent research advances in the molecular and biochemical processes involved in wound healing and skin aging have led to the development of innovative cosmeceuticals that rely on peptides, proteins, and growth factors to enhance skin health. Although the long‐term benefits of these products have not been fully tested and evaluated, evidence of the benefits derived from their use is steadily growing. This study describes the peptides, proteins, and growth factors that are most frequently used in cosmeceuticals and discusses their potential benefits and practical use in dermatology.
Effects of routine premedication for cardiac catheterization on sedation, level of anxiety and arterial oxygen saturation.

OBJECTIVE To assess the efficacy and side effects of routine premedication in patients undergoing cardiac catheterization procedures in a tertiary cardiac care institute. The criteria used included: arterial hemoglobin oxygen saturation (%SaO2), level of sedation and level of anxiety before and after the procedure. Overall patient satisfaction was also quantified. DESIGN Sixty-two adult patients scheduled for cardiac catheterization procedures were recruited for the study. They were premedicated with one of several premedication regimens: oral diazepam 5 to 10 mg; oral lorazepam 1 mg; oral diazepam 10 mg+oral promethazine 25 mg; or oral diazepam 10 mg+oral diphenhydramine 25 mg. No attempt was made to control the premedication the patients received; it was ordered by each patient's cardiologist according to personal preference. Patients underwent pulse oximetry and evaluation of sedation, anxiety and level of satisfaction before and after cardiac catheterization. RESULTS All patients tested had values for mean precatheterization %SaO2 above 92%. No patient had postcatheterization %SaO2 readings below that defined as indicating clinically significant hypoxemia (%SaO2 less than 90%). Patients were awake or lightly sedated before and after cardiac catheterization. Thirteen per cent of patients suffered from high levels of anxiety before, and 16% during, cardiac catheterization. Twenty-three per cent of patients reported being dissatisfied with the premedication before, and 10% of patients reported being dissatisfied during, cardiac catheterization. CONCLUSIONS Clinically significant hypoxemia and oversedation are not problems for most patients given the types and doses of precatheterization medication used in the study population. The premedication schedules followed in the study failed to provide satisfaction and anxiolysis in a significant number of those studied.
Parental Relatedness and Survival of Pacific Oysters from a Naturalized Population

Abstract Inbreeding has profound implications in fields ranging from evolutionary biology to medicine. Most cultured aquatic species are only partially domesticated and highly fecund and are, therefore, expected to have higher genetic load and more severe inbreeding depression than species with lower fecundity and/or longer histories of domestication. Marine bivalves such as oysters are extreme in this regard, and previous studies have demonstrated that self-fertilization, brother/sister matings, and cousin/cousin matings in Pacific oysters (Crassostrea gigas) reduce growth and survival. It is unclear, however, whether these effects can be extrapolated to lower levels of consanguinity such as those expected in natural populations or the founders used to initiate cultured strains or selective breeding efforts. To address this without the need for extensive pedigree information, we studied inbreeding in a naturalized population of Pacific oysters using molecular marker-based estimates of parental relatedness calculated from multilocus microsatellite genotypes. We produced 34 full-sib families using randomly mated parents collected from a naturalized population in Dabob Bay (Washington, USA) and planted them in intertidal and subtidal conditions in Dabob Bay and Yaquina Bay (Oregon, USA). Using 16 microsatellite loci, we estimated the degree of inbreeding of each pair's progeny in three ways: (1) identity ( I ) or the expected homozygosity of the progeny based on their parents' genotypes estimated using the IDENTIX program, (2) a moment-based estimator of the pair-wise coefficient of relatedness ( W ) of each parental pair estimated using the MER program of Wang, and (3) a modified estimator of the pair-wise coefficient of relatedness ( K ) designed specifically to accommodate null alleles, which were common in the Dabob Bay population and estimated using the ML-RELATE by Kalinowski. Using a composite analysis of variance approach to partition the total among-family variation into components attributable to inbreeding and all other family-level effects, we found statistically significant negative relationships between all three estimators of inbreeding and the survival of their progeny when we analyzed all location/exposure combinations simultaneously and in 7 of the 12 separate tests examining each location/exposure combination separately. However, for 4 of the 5 nonsignificant tests, P < 0.07 using K estimator of relatedness, which makes the potentially unreasonable assumption that all parents have inbreeding coefficients (F) of zero. Further, these relationships were strongest at the site with the highest mortality, indicating that inbreeding depression may be more severe in a more stressful environment. Finally, we briefly outline potential strategies for using molecular marker-based estimates of relatedness to improve the genetic composition of new founder populations, incorporation of relatedness information in selective breeding efforts, and minimizing inbreeding effects in established cultured oyster populations.
Towards a Paradigm Shift in the Treatment of Chronic Chagas Disease

ABSTRACT Treatment for Chagas disease with currently available medications is recommended universally only for acute cases (all ages) and for children up to 14 years old. The World Health Organization, however, also recommends specific antiparasite treatment for all chronic-phase Trypanosoma cruzi-infected individuals, even though in current medical practice this remains controversial, and most physicians only prescribe palliative treatment for adult Chagas patients with dilated cardiomyopathy. The present opinion, prepared by members of the NHEPACHA network (Nuevas Herramientas para el Diagnóstico y la Evaluación del Paciente con Enfermedad de Chagas/New Tools for the Diagnosis and Evaluation of Chagas Disease Patients), reviews the paradigm shift based on clinical and immunological evidence and argues in favor of antiparasitic treatment for all chronic patients. We review the tools needed to monitor therapeutic efficacy and the potential criteria for evaluation of treatment efficacy beyond parasitological cure. Etiological treatment should now be mandatory for all adult chronic Chagas disease patients.
Illumination Planning for Object Recognition Using Parametric Eigenspaces

Presents a novel approach to the problem of illumination planning for robust object recognition in structured environments. Given a set of objects, the goal is to determine the illumination for which the objects are most distinguishable in appearance from each other. Correlation is used as a measure of similarity between objects. For each object, a large number of images is automatically obtained by varying the pose and the illumination direction. Images of all objects together constitute the planning image set. The planning set is compressed using the Karhunen-Loeve transform to obtain a low-dimensional subspace, called the eigenspace. For each illumination direction, objects are represented as parametrized manifolds in the eigenspace. The minimum distance between the manifolds of two objects represents the similarity between the objects in the correlation sense. The optimal source direction is therefore the one that maximizes the shortest distance between the object manifolds. Several experiments have been conducted using real objects. The results produced by the illumination planner have been used to enhance the performance of an object recognition system. >
Effectiveness of a Business Intelligence Solution to Manage the Antiretroviral Therapy Programme

The Human Immunodeficiency Virus and Acquired Immune Deficiency Syndrome (HIV/AIDS) has caused the death of millions of people worldwide. To combat the effect of HIV/AIDS, the South African government started with the provisioning of Antiretroviral Therapy (ART) in the public health sector. Monitoring and evaluating the effectiveness of this ART programme is of the utmost importance. A business intelligence approach was followed that first of all integrated several independent operational sources into one data warehouse and then delivered strategic management information with easy to use business intelligence tools that was developed and deployed for the users. The business intelligence solution was then evaluated by the users of the system and the results indicated that the users deemed the solution to be an effective way to obtain strategic information on the rollout of the ARV treatment programme.
Increasing prevalence of coeliac disease in Swedish children: influence of feeding recommendations, serological screening and small intestinal biopsy activity

Background: The prevalence of coeliac disease (CD) in Swedish children has attracted considerable interest over the past few decades, and especially the influence of feeding habits on the increased incidence. A national study has reported a trend towards a decrease in incidence after a change in infant feeding recommendations was introduced in 1996. The aim of this study was to evaluate, in a geographically defined area, the change in incidence with time and the influence of the introduction of antibody analysis. Methods: Cases of suspected paediatric CD between 1980 and 2003 were studied for prevalence, biopsy findings and antibody analyses. Results: A total of 2029 children were investigated by small intestinal biopsy, yielding 554 CD cases. The area initially showed the same trend as the national study, but the annual incidence rate is now increasing again. Median age at diagnosis has increased significantly since 1997 from less than 2 years of age to above 5 years. Cumulative incidence at 2 years of age is much higher for the birth cohorts 1983–96 than 1980–82 or 1997–2001. Diagnostic accuracy was significantly higher after the introduction of antigliadin (AGA) analysis, and especially after antiendomysium (EMA) analysis. Conclusions: The incidence rate of CD in small children in our region has varied widely over the 24‐year period observed. Feeding practice and methods of investigation have changed during this period. The annual incidence rate for the total child population in 2003 was almost equal to the peak value observed in 1994. There were no conclusive results on whether antibody analysis had an influence on diagnostic activity, but this seems to have increased diagnostic accuracy.
Reducing Hospital Use and Expenditures through Utilization Review

Utilization review (UR) has become a prominent approach to cost containment now used by almost 65% of private group insurance plans. Although insurers have increasingly relied on UR to contain health care costs, until recently little was known about the effects of this cost containment approach. This article re views some of the key findings of a UR evaluation, based on analysis of claims data on 223 insured groups for the years 1984 through 1986. The evalu ation found that UR reduced admissions by 12%, in- patient expenditures by 8%, and total expenditures by 6%. It was estimated that UR generated net sav ings of $115 per employee per year. Groups adopting UR with high baseline rates of hospital use had larger expenditure reductions and greater net savings. It appears that UR can play an important role in private cost containment and help improve medical care re source consumption.
The failure of biotin or oxybiotin to exert a "procarcinogenic" effect on tumor formation by 4-dimethylaminoazobenzene.

Oxybiotin, the oxygen analog of biotin (4, 7), possesses biotin-like activity for various micro organisms, the rat, and the chick (4, 8, 15, 17). In this respect, oxybiotin is unique among the vita mins of the B complex, since biological activity is retained in spite of the substitution of the sulfur of the ring by oxygen. It has been demonstrated that the activity of oxybiotin is an intrinsic property of
Coupled Ocean–Atmosphere–Ice Response to Variations in the Southern Annular Mode

Abstract The coupled ocean–atmosphere–ice response to variations in the Southern Annular Mode (SAM) is examined in the National Center for Atmospheric Research (NCAR) Community Coupled Climate Model (version 2). The model shows considerable skill in capturing the predominantly zonally symmetric SAM while regional deviations between model and observation SAM winds go a long way in explaining the generally small differences between simulated and observed SAM responses in the ocean and sea ice systems. Vacillations in the position and strength of the circumpolar winds and the ensuing variations in advection of heat and moisture result in a dynamic and thermodynamic forcing of the ocean and sea ice. Both meridional and zonal components of ocean circulation are modified through Ekman transport, which in turn leads to anomalous surface convergences and divergences that strongly affect the meridional overturning circulation and potentially the pathways of intermediate water ventilation. A heat budget analysis de.
Physical frailty: vulnerability of patients suffering from late-life depression

Objectives: Frailty, a state of increased risk of negative health outcomes, is increasingly recognized as a relevant concept for identifying older persons in need of preventative geriatric interventions. Even though broader concepts of frailty include psychological characteristics, frailty is largely neglected in mental health care. The aim of the present study is to examine the prevalence of physical frailty in depressed older patients and its potential overlap with depression criteria. Method: Cross-sectional observational study including 378 depressed and 132 non-depressed adults aged ≥60 years according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria. Physical frailty was defined as ≥3 out of 5 criteria (handgrip strength, weight loss, poor endurance, walking speed, low physical activity). Results: Prevalence rates of physical frailty were 27.2% and 9.1% among depressed and non-depressed participants, respectively, which remained significant after controlling for relevant covariates (odds ratio [OR] = 2.66 [95% confidence interval [C.I.] = 1.36, 5.24], p = .004). Physical frailty in depression was associated with more severe depressive symptoms; this association remained significant in subsequent analyses with purely physical proxies for frailty (hand grip strength, walking speed) and different severity measures of depressive symptoms. Conclusion: A quarter of depressed older patients is physically frail, especially the most depressed group. This cannot be explained by overlap in criteria and should be examined in future studies, primarily on its presumed clinical relevance.