Miracle-dz/UniFAR-FTUs huggingface dataset:
Cardiac Surgery With Extracorporeal Circulation: Neutrophil Transendothelial Migration Is Mediated by β1 Integrin (CD29) in the Presence of TNF-Alpha

Cardiac surgery with extracorporeal circulation is associated with neutrophil activation, inflammation, and edema. Endothelial hyperpermeability elicited by the interaction of activated neutrophils and/or cytokines with endothelial cells may be critical in this regard. However, the immune and cellular mechanisms involved are not fully understood. Cocultures with human endothelial cells and neutrophils from cardiac surgery patients were used to evaluate the role of β1 integrin activity and the proinflammatory cytokine tumor necrosis factor (TNF)-α in neutrophil transendothelial migration and in impairment of the integrity of endothelial cell-to-cell contacts. Blocking of CD29 (heavy chain of β1 integrins) totally prevented neutrophil adhesion and transendothelial migration. Pretreatment of neutrophils with either a CD29-stimulating monoclonal antibody or the addition of TNF-α (0.1–10 U/ml) to the coculture failed to induce transendothelial migration. However, coculture of endothelial cells with CD29-stimulated neutrophils in the presence of 0.1–10 U/ml TNF-α strongly induced neutrophil transmigration. CD29/TNF-α-mediated transmigration was associated with intracellular redistribution of endothelial β-catenin. We further showed that CD29/TNF-α-mediated effects involved PI3K and tyrosine kinase-dependent signaling via MAPK but were independent of nuclear transcription factor (NF)-κB activity. Inhibition of CD29/TNF-α might be a therapeutic option to limit endothelial dysfunction following cardiac surgery with extracorporeal circulation.
The Management of Cubital Tunnel Syndrome: A Meta-Analysis of Clinical Studies

Despite extensive clinical experience in treating cubital tunnel syndrome, optimal surgical management remains controversial. A meta-analysis of 30 studies with accurate preoperative and postoperative staging was undertaken. Patients were staged preoperatively into minimum, moderate, and severe groups on the basis of clinical presentation. Treatment modalities included nonoperative management, surgical decompression, medial epicondylectomy, anterior subcutaneous transposition, and anterior submuscular transposition. Statistical analysis using a standard SAS database with analysis of variance and chi-square tests was used to assess the efficacy of each therapeutic modality. For minimum-staged patients, all modalities produced similar degrees of satisfaction. However, total relief occurred most after medial epicondylectomy and least after anterior subcutaneous transposition. Patients treated nonoperatively had the highest rate of recurrence. For moderate-staged patients, submuscular transposition was most efficacious, whereas patients with nonoperative management fared the worst. Finally, for severe-staged patients, current therapeutic modalities were not consistently effective, with medial epicondylectomy producing the poorest operative result. This article reveals statistically significant differences in outcomes among therapeutic modalities, which may assist in treatment planning; it introduces standardized methods to aid in determining, analyzing, and communicating treatment outcomes. (Plast. Reconstr. Surg. 106: 327, 2000.)
The effects of regulatory pressure on information system adoption success: An institutional theory perspective

The central idea of this paper is to comprehend knowledge integration in inter-organizational IS projects through a knowledge cluster view of inter-organizational IS projects. The proliferation of such projects combined with the complexity of managing them, motivated this study. The study is based on a single case study which involves four organizations collaborating on a project. Findings suggest that knowledge integration in inter-organizational projects occurs through knowledge clusters and involves the interaction of complementary specialized knowledge bases within a structure and influenced by the clusters’ perceptions towards the project. Implications of the findings and future research opportunities are discussed.
Translational inhibition mediated by a short upstream open reading frame in the human cytomegalovirus gpUL4 (gp48) transcript

The human cytomegalovirus (CMV) virion glycoprotein gpUL4 (gp48) gene expresses a transcript that contains three AUG codons upstream from the one used to initiate synthesis of the gp48 protein. Previously we reported that the second of these AUG codons, AUG2, was necessary but insufficient for inhibition of downstream translation (M. Schleiss, C. R. Degnin, and A. P. Geballe, J. Virol. 65:6782-6789, 1991). We now demonstrate that the coding information of the upstream open reading frame initiated by AUG2 (uORF2) is critical for the inhibitory signal. Several missense mutations, particularly those involving the carboxy-terminal codons of uORF2, inactivate the inhibitory signal, while mutations that preserve the coding content of uORF2 uniformly retain the inhibitory signal. The uORF2 termination codon is essential for inhibition, but leader sequences further downstream are not critical. Conservation of uORF2 among clinical strains of CMV suggests that uORF2 provides an important function in the CMV infectious cycle. Although these results indicate that the peptide product of uORF2 mediates the inhibitory effect, we demonstrate that the uORF2 signal acts only in cis, and we propose a model of inhibition by the gp48 uORF2 signal.
Hypokalaemia in ibuprofen and codeine phosphate abuse

Ibuprofen abuse may be more prevalent than generally considered. Although normally benign, serious complications have been documented. We report an unusual presentation of hypokalaemia and its associated symptoms as a result of Nurofen Plus® (200 mg ibuprofen + 12.8 mg codeine phosphate) abuse. Ibuprofen is generally not included in a standard toxicology screen, but should be considered as a rare cause of hypokalaemia.
A Feasible Approach for Direct His‐Bundle Pacing Using a New Steerable Catheter to Facilitate Precise Lead Placement

Introduction: Much clinical evidence has shown that right ventricular (RV) apical pacing is detrimental to left ventricular function. Preservation of the use of the His‐Purkinje (H‐P) system may be ideal in heart block that is restricted to the AV node, but may be of no benefit when H‐P disease exists.
Pathology and Clinical Features of Gastrointestinal Lymphoma in Saudi Arabia

The histopathology and clinical presentation of 19 cases of primary gastrointestinal lymphoma is described. Our patients are similar to others in the Middle East but have a lower incidence of diarrhoea and malabsorption. All revealed a widespread chronic inflammatory background. Four patients with primary gastric lymphoma had endoscopic biopsies from the duodenum; these biopsies were completely free from tumour but showed a moderate to severe diffuse lymphoplasmacytic infiltrate. Electron microscopy shows that tumour cells penetrate basement membranes and invade the epithelium which becomes thin and attenuated. Substances which inhibit lymphocyte tropism might be useful in preventing intestinal ulceration. The MALT concept has been found useful in classification of the tumours. Two patients with unusual mesenteric node histology are described and it is thought that the appearances may indicate a substantial capacity for differentiation in the group of tumours.
Antimicrobial effect of Anacardium occidentale leaf extract against pathogens causing periodontal disease

The oral cavity is perpetually colonized by different species of microorganisms and at times it is difficult to characterize the periodontal pathogen causing breakdown of tissue and bone. But over the years, based on scientific knowledge, it has been observed that various gram negative anaerobic bacteria have been involved with the initiation of periodontal disease. Based on literature reviews, a study was undertaken to investigate the antimicrobial effect of Anacardium occidentale (cashew) leaf extract on Porphyromonas gingivalis and Prevotella intermedia. Methanol and aqueous extracts of cashew leaves were prepared. Its antimicrobial activity against P. gingivalis and P. intermedia was tested using the agar diffusion method at various dilutions of 75 μ, 50 μl, 25 μl, 10 μl and 5 μl respectively. 0.2% Clorhexidine gluconate (CHX) was used as control. Cultures of P. gingivalis and P. intermedia strains were maintained on Kanamycin blood agar. The agar plates were then incubated at 37? C for 72 hours after which the zone of inhibition was measured and the mean was recorded for each test solution. The results of this study demonstrated that, for both P. gingivalis and P. intermedia, the highest concentration (75 μl) of both the extracts showed maximum antimicrobial action. For P. ginigvalis, the aqueous extract demonstrated significant inhibitory activity compared to the methanolic extract (p = 0.005), which was comparable to that of CHX. For P. intermedia, similar results were observed with aqueous extract being more effective compared to methanolic (p = 0.007), however, CHX was most effective compared to both the extracts (p = 0.007). This study revealed that Anacardium occidentale leaf extracts have efficient antimicrobial activity against P. gingivalis & P. intermedia. Hence, this preliminary study suggests that the antimicrobial action of A. occidentale leaf could be utilized for the preparation of chemical plaque control formulations.
Immobilization of Bacillus megaterium MTCC 2444 by Ca-alginate entrapment method for enhanced alkaline protease production

Optimization of culture conditions and immobilization parameters for alkaline protease production was carried out by employing Bacillus megaterium MTCC2444. The partially purified enzyme was tested for its stability in the presence of oxidants, surfactants and commercial detergents. The optimum temperature, pH, incubation time and inoculum size were 55 oC, 11, 48 h, 1 %, respectively. Calcium alginate was used as the immobilization matrix and the effects of gel concentration, bead size, age of immobilized cells, solidification period and initial biomass concentration on alkaline protease production and cell leakage were investigated. The results indicated that the immobilization was most effective with 4 % gel concentration, bead size of 3 mm, 24 h aged immobilized cells for a solidification period of 12 h at 1.5 % initial biomass concentration. The enzyme showed good stability in the presence of oxidants, surfactants and commercial detergents.
HMOEDA_LLE: A hybrid multi-objective estimation of distribution algorithm combining locally linear embedding

Based on the regularity that: the Pareto set of a continuous m-objectives problem is a piecewise continuous (m-1)-dimensional manifold, a novel hybrid multi-objective optimization algorithm is proposed in this paper. In the early evolutionary stage, traditional crossover and mutation operations are used to produce offspring, in addition, the locally linear embedding (LLE) with small neighbor parameter approach is introduced to learn the local geometry of the manifold. When certain regularity in population's distribution is detected, new offspring are sampled from the probability models created by the statistical distribution information. An entropy-based criterion is imported to determine the switching time of the two different phases of evolutionary search. The proposed hybrid multi-objective estimation of distribution algorithm combining locally linear embedding (HMOEDA_LLE) adopts several widely used test problems to conduct the comparison experiments with two state-of-the-art multi-objective evolutionary algorithms NSGA-II and RM-MEDA. The simulated results show the effectiveness of the entropy-based criterion and the proposed algorithm has better optimization performance.
Narcissism, Director Selection, and Risk-Taking Spending

We explain why CEOs favor new directors who are similar in narcissistic tendency or have prior experience with other similarly narcissistic CEOs. Because powerful CEOs are more able to select such individuals onto their boards, CEO power is predicted to be positively associated with the above characteristics of new directors. These associations are expected to be stronger when a new director is more different from the CEO in salient demographic characteristics. Moreover, we explain why new directors favored by CEOs are more supportive of their decision making, strengthening the positive relationship between CEO narcissism and risk-taking spending. Our findings provide considerable support for our theory. This study introduces personality theories to corporate governance research on director selection and to research on how triads influence dyadic relations
The role of source of protein in regulation of food intake, satiety, body weight and body composition

Submit Manuscript | http://medcraveonline.com Abbreviations: AA: Amino Acid; BAP: Bioactive Peptide; BBB: Blood Brain Barrier; BCAA: Branched Chain Amino Acid; BMI: Body Mass Index; CCK: Cholecystokinin; CHO: Carbohydrate; DPP-IV: Dipeptidyl Peptidase IV; EWH: Egg White Hydrolysate; GI: Gastro-Intestinal Tract; GLP-1: Glucagon like Peptide; GMP: Glycomacropeptide; ICV: Intracerebroventricular; IPP: IsoleucineProline-Proline; kg: kilogram; m: meter; PYY: Peptide YY; VPP: Valine-Proline-Proline
Detection of circulating endothelial cells and endothelial progenitor cells by flow cytometry

The finding of angiogenic and vasculogenic cells in the peripheral circulation may have profound effects on the course of a variety of diseases ranging from cancer to cardiovascular disease. These cells are ascribed to be endothelial in nature and are generally referred to as circulating endothelial cells if mature or as endothelial progenitor cells if immature. Different approaches have been used to detect these cells, including in vitro culture, magnetic bead isolation, and flow cytometry. We review flow cytometric methods for the detection and enumeration of these cells and provide technical suggestions to promote the accurate enumeration of circulating endothelial cells and endothelial progenitor cells. Published 2005 Wiley‐Liss, Inc.
GenVirtual: An Augmented Reality Musical Game for Cognitive and Motor Rehabilitation

Electronic games have been used to stimulate cognitive functions such as attention, concentration and memory. This paper presents GenVirtual, which is an augmented reality musical game and is proposed to help people with learning disabilities. The intention is to help the patient in the following skills: creativity, attention, memory (storage and retrieval), planning, concentration, ready-response, hearing and visual perception, and motor coordination. The therapist has flexibility to place the musical and visual elements, allowing him to create different scenarios to each patient. GenVirtual uses Augmented Reality technology to allow people with physical disorders to interact with the game. Patients with no fingers can also play this game. GenVirtual was evaluated by a music therapist who considered it as a facilitating and motivating game to the learning process and that it has the potential to improve the life of the people with special needs.
Development of an algorithmic trading model for intraday trading on stock markets based on technical analysis methods

The theory of technical analysis suggests that future stock price movements can be forecasted by analyzing historical price changes and studying repetitive patterns. In this thesis we aim at implementing technical trading rules in intraday trading. In theoretical part the descriptions and explanations of applying indicators and rules in intraday trading are provided. Three types of approaches – price, volume and market microstructure analysis for determining market changes are researched. A range of trading rules are empirically tested and based on the findings an algorithmic trading model is constructed.
A climatology of stratospheric polar vortices and anticyclones

[1] United Kingdom Meteorological Office global analyses from 1991 to 2001 are used to create a global climatology of stratospheric polar vortices and anticyclones. New methodologies are developed that identify vortices in terms of evolving three-dimensional (3-D) air masses. A case study illustrates the performance of the identification schemes during February and March of 1999 when a merger of anticyclones led to a stratospheric warming that split the Arctic polar vortex. The 3-D structure and temporal evolution of the Arctic vortex and identified anticyclones demonstrates the algorithm’s ability to capture complicated phenomena. The mean geographical distribution of polar vortex and anticyclone frequency is shown for each season. The frequency distributions illustrate the climatological location and persistence of polar vortices and anticyclones. A counterpart to the Aleutian High is documented in the Southern Hemisphere: the ‘‘Australian High. ’’ The temporal evolution of the area occupied by polar vortices and anticyclones in each hemisphere is shown as a function of potential temperature. Large polar vortex area leads to an increase in anticyclone area, which in turn results in a decrease in the size of the polar vortex. During Northern winter and Southern spring, 9 years of daily anticyclone movement are shown on the 1200 K (36 km, 4 hPa) isentropic surface. Preferred locations of anticyclogenesis are related to cross-equatorial flow and weak inertial stability. Regimes of traveling and stationary anticyclones are discussed. INDEX TERMS: 3309 Meteorology and Atmospheric Dynamics: Climatology (1620); 3319 Meteorology and Atmospheric Dynamics: General circulation; 3334 Meteorology and Atmospheric Dynamics: Middle atmosphere dynamics (0341, 0342); KEYWORDS: polar vortex, stratospheric anticyclones
Predicting Intelligibility Gains in Individuals With Dysarthria From Baseline Speech Features.

Purpose Across the treatment literature, behavioral speech modifications have produced variable intelligibility changes in speakers with dysarthria. This study is the first of two articles exploring whether measurements of baseline speech features can predict speakers' responses to these modifications. Methods Fifty speakers (7 older individuals and 43 speakers with dysarthria) read a standard passage in habitual, loud, and slow speaking modes. Eighteen listeners rated how easy the speech samples were to understand. Baseline acoustic measurements of articulation, prosody, and voice quality were collected with perceptual measures of severity. Results Cues to speak louder and reduce rate did not confer intelligibility benefits to every speaker. The degree to which cues to speak louder improved intelligibility could be predicted by speakers' baseline articulation rates and overall dysarthria severity. Improvements in the slow condition could be predicted by speakers' baseline severity and temporal variability. Speakers with a breathier voice quality tended to perform better in the loud condition than in the slow condition. Conclusions Assessments of baseline speech features can be used to predict appropriate treatment strategies for speakers with dysarthria. Further development of these assessments could provide the basis for more individualized treatment programs.
Distributed generation of weighted random patterns

A new weighted random pattern (WRP) design for testability (DFT) is described where the shift register latches (SRLs) distributed throughout the chip are modified so that they can generate biased pseudo-random patterns upon demand. A two-bit code is transmitted to each WRP SRL to determine its specific weight. The WRP test is then divided into groups, where each group is activated with a different set of weights. The weights are dynamically adjusted during the course of the test to "go after" the remaining untested faults. The cost and performance of this design system are explored on three pilot chips. Results of this experiment are provided in the paper.
Technology Complexity, Personal Innovativeness And Intention To Use Wireless Internet Using Mobile Devices In Malaysia

Wireless Internet on mobile devices (WIMD) technology is rapidly growing in many countries including Malaysia. As WIMD is still in its growing stage, it is appropriate to conduct research on technology adoption of WIMD. This paper analyses the intention to use WIMD among Malaysians. The study adopted the Technology acceptance model (TAM) as it is considered to be one of the best models to study technology adoption. Questionnaires were distributed to 350 mobile phone and Internet users, from which 301 responded. The findings show Technology complexity and personal innovativeness have a positive impact on intention to use WIMD.
Regional clustering through internet networks: the case of web-enabled entrepreneurial cluster in China

This research examines the rationale of geographic co-location of entrepreneurs who do business on internet platforms. Prior research has shown that entrepreneurs gain valuable synergy benefits from being embedded in industrial networks. Nevertheless, the advantages of geographic clustering when business is conducted via the internet are still to be understood. This research aims to understand how internet-based economic activity interacts with local social relations and structures, thus seeking to explain the phenomenon of industrial clustering of internet-enabled entrepreneurial activity. Guided by theories of relational and institutional embeddedness, we examine the way social relations are formed online, trace the rationale of local social relations while business is conducted online, and study the role of major institutional actors that support the economic activities of the entrepreneurs. Empirically, this thesis examines two regional clusters of Chinese microentrepreneurs who conduct their business on an e-commerce platform and form dynamic interpersonal ties with business partners and customers both online and offline. The method of ethnographic case study is adopted to gain in depth understanding of the ways various internet networking tools have been appropriated in business practice in these two cases and the ways local microentrepreneurs build up collaborative networks in geographic place as well as cyberspace. The study of Chinese micro-entrepreneurs reveals and substantiates the formation of a hybrid sociality, whereby economic exchange via the internet and business conducted by electronic tools are complemented by local social relations and actively supported by local government and the IT service corporation. This research also contributes to development policy considerations; it shows that regions that are usually unattractive to capital and knowledge/talent flows can gain economic development momentum by entangling the conduct of business on web platforms with local social institutions.