Miracle-dz/UniFAR-FTUs huggingface dataset:
The H 63 D mutation in the HFE gene is related to the risk of hepatocellular carcinoma

Objetivo: comprobar si las mutaciones del gen HFE, que pueden inducir sobrecarga hepática de hierro, guardan relación con el riesgo de desarrollar carcinoma hepatocelular (CHC) en sujetos predispuestos a sufrir este tumor. Material y métodos: se han incluido 196 pacientes (161 varones) diagnosticados de CHC. Ninguno estaba diagnosticado de hemocromatosis. El grupo control estaba constituido por 181 sujetos sanos. Todos los sujetos eran españoles de raza blanca. Las mutaciones C282Y y H63D del gen HFE se identificaron mediante reacción en cadena de polimerasa (PCR) sobre ADN genómico leucocitario utilizando enzimas de restricción específicas. Resultados (casos/controles): 1. Distribución genotípica: a) mutación C282Y: 1/0 homocigotos, 12/23 heterocigotos, 183/158 normales (p = 0,07, n.s.); y b) mutación H63D: 9/5 homocigotos, 85/52 heterocigotos, 102/124 normales (odds ratio 2,00, IC95% 1,29-3,12, p = 0,002). Cuatro casos y seis controles eran heterocigotos compuestos. 2. Frecuencias alélicas: a) mutación C282Y: normales 378/339, mutados 14/23 (p = 0,11, n.s.); b) mutación H63D: normales 289/300; mutados 103/62 (odds ratio 1,72, IC95% 1,19-2,50, p = 0,004). No se observaron diferencias en relación con el sexo, la edad o la etiología (VHC, VHB, etílica o mixta) de la hepatopatía previa. Conclusiones: la mutación C282Y no guarda relación con el riesgo de desarrollar CHC en sujetos sin hemocromatosis conocida. La posesión de la mutación H63D se asocia con un riesgo aumentado de desarrollar CHC independientemente de la etiología de la hepatopatía crónica subyacente.
Density-driven defect-mediated network collapse of GeSe2 glass

The evolution in structure of the prototypical network-forming glass GeSe2 is investigated at pressures up to ∼16 GPa by using a combination of neutron diffraction and first-principles molecular dynamics. The neutron diffraction work at pressures8.2 GPa employed the method of isotope substitution, and the molecular dynamics simulations were performed with two different exchange-correlation functionals, the Becke-Lee-Yang-Parr (BLYP) and the hybrid Heyd-Scuseria-Ernzerhof HSE06. The results show density-driven structural transformations that differ substantially from those observed in common oxide glasses such as SiO2 and GeO2. Edge-sharing tetrahedra persist as important structural motifs until a threshold pressure of ∼8.5 GPa is attained, whereupon a mediating role is found for homopolar bonds in the appearance of higher coordinated Ge-centered polyhedra. These mechanisms of network transformation are likely to be generic for the class of glass-forming materials where homopolar bonds and fragility-promoting edge-sharing motifs are prevalent in the ambient-pressure network.
Usefulness of a new sensorimotor control scale in patients with gonarthrosis and after total knee replacement

Introduction. The importance of sensorimotor control assessment as a crucial factor determining functional recovery is being increasingly appreciated in clinical practice. The aim of this study was to assess the influence of damage associated with severe gonarthrosis on changes in proprioception and sensorimotor control of the knee, compare the results of a new sensorimotor control test developed by the authors with objective methods of proprioception assessment, and analyse the relation between the level of proprioception and sensorimotor system function and the measurements used in clinical practice. Material and methods. We studied a group of healthy persons (control group, n=74), patients with stage 4 knee osteoarthritis (group 1, n=67), and patients after total knee arthroplasty (group 2, n=62). The participants were assessed with a new sensorimotor control test (TKS) and a joint position sense test (JPS). Moreover, we analysed the patients’ HSS knee scores and Staffelstein scores. stresZcZenIe Wstęp. Coraz większą uwagę w praktyce klinicznej zwraca się na ocenę sprawności sensomotorycznej jako istotnego czynnika determinującego powrót funkcji. Celami niniejszej pracy były: ocena wpływu uszkodzeń związanych z zaawansowaną gonartrozą na zmianę czucia głębokiego i kontroli sensomotorycznej stawu kolanowego, porównanie wyników uzyskanych we własnym teście kontroli sensomotorycznej z obiektywnymi metodami oceny czucia głębokiego, analiza zależności pomiędzy poziomem czucia głębokiego i sprawnością układu sensomotorycznego a pomiarami stosowanymi w praktyce klinicznej. Materiał i metody. Ocenie poddano grupę osób zdrowych (grupa kontrolna, n=74), grupę pacjentów z chorobą zwyrodnieniową IV st. (grupa 1, n=67) oraz pacjentów po endoprotezoplastyce stawu kolanowego (grupa 2, n=62). Badanych oceniano z wykorzystaniem autorskiego Testu Kontroli Sensomotorycznej (TKS) oraz testu czucia pozycji stawu (JPS). Analizowano również wyniki uzyskane w skalach HSS Knee Score i Staffelstein-Score. Artykuł otrzymano / recived: 8.09. 2014 | Zaakceptowano do publikacji / accepted: 16.02. 2015 Udział współautorów / Participation of co-authors: A – przygotowanie projektu badawczego/ preparation of a research project; B – zbieranie danych / collection of data; C – analiza statystyczna / statistical analysis; D – interpretacja danych / interpretation of data; E – przygotowanie manuskryptu / preparation of a manuscript; F – opracowanie piśmiennictwa / working out the literature; G – pozyskanie funduszy / obtaining funds PrAcA orygInAlnA / orIgInAl PAPer © Wydawnictwo UR 2015
Patterns of urban development in Budapest after 1989

This paper will focus on various interrelated, intermingled but often divergent processes and phenomena condensed around the fall of communism in Budapest regarding the spatial structure and development of society and economy. It will demonstrate and analyze major tendencies, such as urban decay, gentrification, suburbanization, emergence of polycentric spatial patterns, effects of globalization, and economic proceedings that have fundamentally altered the position and picture of Budapest and its metropolitan area. It will point out local characteristics as well as the effects of general trends of socio-spatial development on Budapest and its surroundings.
Management students’ engagement with industry: an embedded approach to scaffolding employability skills

Many universities have underpinned their curricula with statements of graduate skills and the aim that their graduates will possess attributes which will make them professionally ready for the workforce. At Victoria University (VU) the ‘Making VU’ project has committed to all courses having 25% of assessment linked to workplace activities to increase students’ employment prospects. Linking graduate employability skills with discipline specific assessment is one route to achieving such an outcome. This paper will explore how assessment tasks in two units of study are used in developing employability skills through students moving from being self-directed learners to self-directed reflective learners.
6 Medication-related adverse events during hospitalisation : a retrospective record review study in the netherlands

Purpose Medication-related adverse events (MRAEs) are an important priority for patient safety. Results from Dutch AE studies showed that – despite various improvement initiatives the incidence of preventable MRAEs did not decline. The aim of this study is to describe the characteristics of MRAEs during hospitalizations, using national patient data from records of patients admitted to Dutch hospitals in 2008 and 2011/2012. Methods Trained nurses and physicians reviewed the randomly selected records of 8,071 patients admitted to one of 20 hospitals in 2008 or 2011/2012, during a two-stage review process. Patient and admission characteristics were collected. After identification of a MRAE, physicians determined their potential preventability, drug type, related prescribing factors, and potential consequences. Results The physicians identified 928 AEs in 857 admissions, of which 218 (15.2%) were medicationrelated. They judged 55 (18.4%) of these as preventable. Preventability of MRAEs was high in anticoagulant treatment (42.5%). Haematoma (39.0%) and intra-cerebral haemorrhage (25.5%) were common types of anticoagulant-related AEs. Anticoagulant-related AEs were often related to dosage factors (46.9%) and often resulted in an intervention (80.2%), of which 40.2% was judged as preventable. Conclusions This study provided detailed information on MRAEs during hospital admissions in the Netherlands. A substantial proportion of AEs was medication-related (15.2%), of which 18.4% was judged to be preventable. As preventability in MRAEs was especially high in anticoagulant treatment (42.5%), those medications are a threat to patient safety. Future research and new safety programs should focus on prevention of AEs related to this medication group. PS_REBECCA_def. indd 112 20-12-17 10:53 113 MedIcaTIon-RelaTed adVeRse eVenTs duRInG HosPITalIsaTIon
ASLEEP OR NOT ASLEEP?

Sleep is important for the recovery of a critically ill patient, as lack of sleep is known to influence negatively a person’s cardiovascular system, mood, orientation, and metabolic and immune function and thus, it may prolong patients’ intensive care unit (ICU) and hospital stay. Intubated and mechanically ventilated patients suffer from fragmented and light sleep. However, it is not known well how non-intubated patients sleep. The evaluation of the patients’ sleep may be compromised by their fatigue and still position with no indication if they are asleep or not. The purpose of this study was to evaluate ICU patients’ sleep evaluation methods, the quality of non-intubated patients’ sleep, and the sleep evaluations performed by ICU nurses. The aims were to develop recommendations of patients’ sleep evaluation for ICU nurses and to provide a description of the quality of non-intubated patients’ sleep. The literature review of ICU patients’ sleep evaluation methods was extended to the end of 2014. The evaluation of the quality of patients’ sleep was conducted with four data: A) the nurses’ narrative documentations of the quality of patients’ sleep (n=114), B) the nurses’ sleep evaluations (n=21) with a structured observation instrument C) the patients’ self-evaluations (n=114) with the Richards-Campbell Sleep Questionnaire, and D) polysomnographic evaluations of the quality of patients’ sleep (n=21). The correspondence of data A with data C (collected 4–8/2011), and data B with data D (collected 5–8/2009) were analysed. Content analysis was used for the nurses’ documentations and statistical analyses for all the other data. The quality of non-intubated patients’ sleep varied between individuals. In many patients, sleep was light, awakenings were frequent, and the amount of sleep was insufficient as compared to sleep in healthy people. However, some patients were able to sleep well. The patients evaluated the quality of their sleep on average neither high nor low. Sleep depth was evaluated to be the worst and the speed of falling asleep the best aspect of sleep, on a scale 0 (poor sleep) to 100 (good sleep). Nursing care was mostly performed while the patients were awake, and thus the disturbing effect was low. The instruments available for nurses to evaluate the quality of patients’ sleep were limited and measured mainly the quantity of sleep. Nurses’ structured observatory evaluations of the quality of patients’ sleep were correct for approximately two thirds of the cases, and only regarding total sleep time. Nurses’ narrative documentations of the patients’ sleep corresponded with patients’ self-evaluations in just over half of the cases. However, nurses documented several dimensions of sleep that are not included in the present sleep evaluation instruments. They could be classified according to the components of the nursing process: needs assessment, sleep assessment, intervention, and effect of intervention. Valid, more comprehensive sleep evaluation methods for nurses are needed to evaluate, document, improve and study patients’ quality of sleep.
PAH features within few hundred parsecs of active galactic nuclei

Spectral features from polycyclic aromatic hydrocarbon (PAH) molecules observed in the mid-infrared (mid-IR) range are typically used to infer the amount of recent and ongoing star formation on kiloparsec scales around active galactic nuclei (AGN) where more traditional methods fail. This method assumes that the observed PAH features are excited predominantly by star formation. With current ground-based telescopes and the upcoming James Webb Space Telescope, much smaller spatial scales can be probed and we aim at testing if this assumption still holds in the range of few tens to few hundreds of parsecs. For that, we spatially map the emitted 11.3 μm PAH surface flux as a function of distance from 0.4–4 arcsec from the centre in 28 nearby AGN using ground-based high-angular-resolution mid-IR spectroscopy. We detect and extract the 11.3 μm PAH feature in 13 AGN. The fluxes within each aperture are scaled to a luminosity-normalized distance from the nucleus to be able to compare intrinsic spatial scales of AGN radiation spanning about two orders of magnitude in luminosity. For this, we establish an empirical relation between the absorption-corrected X-ray luminosity and the sublimation radius in these sources. Once normalized, the radial profiles of the emitted PAH surface flux show similar radial slopes, with a power-law index of approximately −1.1, and similar absolute values, consistent within a factor of a few of each other as expected from the uncertainty in the intrinsic scale estimate. We interpret this as evidence that the profiles are caused by a common compact central physical process, either the AGN itself or circumnuclear star formation linked in strength to the AGN power. A photoionization-based model of an AGN exciting dense clouds in its environment can reproduce the observed radial slope and confirms that the AGN radiation field is strong enough to explain the observed PAH surface fluxes within ∼10–500 pc of the nucleus. Our results advice caution in the use of PAH emission as a star formation tracer within a kpc around AGN.
Changes of Ginsenosides and Color from Black Ginsengs Prepared by Steaming-Drying Cycles

This study was conducted to investigate changes in composition of ginsenosides and color of processed gin- sengs prepared by different steaming-drying times. Processed ginsengs were prepared from white ginseng with skin by 9- time repeated steaming at 96℃ for 3 hours and followed by hot air-drying at 50℃ for 24 hours. As the times of steaming processes increased, lightness (L value) decreased and redness (a value) increased in color of ginseng powders. Crude sapo- nin contents and ginsenosides compositions in processed ginsengs prepared by different steaming-drying times were investi- gated using the HPLC method, respecively. Crude saponin contents according to increasing steaming-drying times decreased in some degree. In the case of major ginsenosides, the contents of Rb1, Rb2, Rc, Rd, Rf, Re, Rg1, Re were decreased with increase in steamimg times, but those of Rh1, Rg3, Rk1 were increased after especially 3 times of steaming processes. Interestingly, in black ginseng were prepared by 9 times steaming processes, the content of ginsenoside Rg3 was 8.20 ㎎/g, approximately 18 times higher than that (0.46 ㎎/g) in red ginseng. In addition, the ratio of the protopanaxadiol group and protopanaxatiol group (PD/PT) were increased from 1.9 to 8.4 due to increasing times of steamming process.
Legislative Changes and Abnormal Trading Around Earnings Announcements: Evidence from New Zealand Market

Using semi-annual earnings announcement data in New Zealand from 1998 to 2014, we find evidence of significant pre-announcement price run-ups prior to "good news" announcements, which is a prima facie evidence of abnormal trading. We then investigate the effectiveness of changing regulations. Our results suggest that tightening disclosure requirements and using a centralized regulatory authority successfully reduced abnormal trading activity, however introducing criminal offense to insider trading had no effect on reducing such activity, likely due to the increased burden of proof needed in prosecution. Further analysis using high frequency data also supports this finding. These findings have meaningful policy implications and raise important questions on financial markets regulation.
HOUSING PRICES AND EDUCATION LEVEL A study on the effects of the number of highly educated residents on regional housing prices in the Netherlands Name :

This focus of this research was to find whether the number of highly educated residents has a significant effect on regional housing prices in the Netherlands. The model used to conduct the statistical analysis was based on a model of house price determinants constructed by Alan K. Reichert (1990). His model was extended with a variable for the number of highly educated residents per region. The study finds that the number of highly educated residents has a significant positive effect on housing prices, at a ten percent significance level.
Comparison between Uses of Therapeutic Exercise and Heat Application on Relieve Pain , Stiffness and Improvement of Physical Function for Patient with Knee Osteoarthritis

Osteoarthritis is a common chronic disease and a major worldwide problem for medical, psychosocial, and economic reasons. Osteoarthritis leads to considerable morbidity in terms of pain, functional disability, lowered quality of life, and psychological problems and affected people are mainly cared for in the community. The aim of this study was to compare between uses of therapeutic exercise and heat application on relieve pain, stiffness and improvement of physical function for patient with knee osteoarthritis. This quasiexperimental study was conducted in the out patient clinic of orthopedic at Mansoura University main hospital. The data were collected from a convenience sample of 90 osteoarthritis patients of both sex and equally divided into 3 groups (G1) received training to used heat application with pharmacological treatment to decrease symptoms of osteoarthritis, (G2) received training of physical exercise with pharmacological treatment to decrease symptoms of osteoarthritis, (G3) received a combination training from physical exercise and heat application with pharmacological treatment prescribed by physician. The main inclusion criteria was diagnosis osteoarthritis of the knee based on attendant to out patient clinic at least twice / week. Results: knee stiffness improves from {mean= (G1, G2 & G3) 9.17, 22.08& 1.25 respectively to 66.25, 47.92& 85 respectively} after implementing education intervention. There were statistical significant difference between the three groups of studied sample pre – post teaching phase regarding experiencing total knee stiffness score ( P ≤ 0,001, 0,001& 0,001 respectively). Conclusion: the use of a combination of therapeutic exercise and heat application together for relieving pain, stiffness and improving physical function for patient with osteoarthritis was successful [Wafaa I. Shereif and Amira A. Hassanin, Comparison between Uses of Therapeutic Exercise and Heat Application on Relieve Pain, Stiffness and Improvement of Physical Function for Patient with Knee Osteoarthritis] Life Science Journal,. 2011; 8(3): 388-396] (ISSN: 1097-8135). http://www.lifesciencesite. com.
Physiological quality of soybean seeds in fixed-bed dryer with air radial distribution

In recent years few countries have grown as much in international agribusiness trade as in Brazil, where soybean (Glycine max (L.) Merrill) is one of the economic activities that have contributed most. However, in order to increase or maintain the efficiency of the oilseed, it is necessary to increase the knowledge in the post-harvest techniques that are applied to the seeds to maintain their quality. This study aimed at evaluation of the physiological quality and the drying uniformity of soybean seeds in a commercial fixed-bed dryer of the brand Granfinale and industrial ventilator of the brand AeroMack with the radial distribution of air. Samples were collected at 4 vertical heights: 0.20, 1.40, 2.60 and 3.80 meters at the dryer base combined with 4 radial distances of 0.15, 0.30, 0.45 and 0.60 meters and central duct, through a 4x4 random factorial scheme. The following analyzes were performed on seeds: Water Content (WC), Germination Standard Test (GST), First count of Germination Standard Test (FCT), Accelerated Aging (AA), Electric Conductivity (EC) and Germination Velocity Index (GVI). The analysis of variance and regression analysis were performed, when applicable. We found a super drying in the lower layer and retardation in the upper layer of stationary drying. The seeds located at vertical heights of 0.20 and 1.40 m obtained the highest mean values of Germination Standard Test and Accelerated Aging. On the other hand, seeds located at vertical heights of 0.20 m, regardless of radial distances, showed less vigor according to Electric Conductivity test in relation to the other treatments. The variables First count of Germination Standard Test (FCT) and Germination Velocity Index (GVI) were not significantly influence by the evaluated treatments and their interaction.
Radial Variation in Sap Flux Density as a Function of Sapwood Thickness in Two Eucalyptus ( Eucalyptus urophylla ) Plantations

Radial variation in sap flux density (SFD) as a function of sapwood thickness is of importance in accurately estimating sap flux through sapwood area which, in turn, decides the precision of heat pulse application. However, until now, only a few studies have evaluated the magnitude and significance of sampling errors associated with radial gradients in SFD, which were based on the small monitoring measurement data from a few trees. Based on one year of heat pulse observation of two 3-4 years old Eucalyptus urophylla S.T. Blake plantations in Leizhou Peninsula, Guangdong Province, China, a way of data processing was developed to treat with the lots of SFD data measured from 39 trees. It was found that the radial variation in SFD as a function of sapwood thickness in the two eucalyptus plantation sites could be expressed as y=3.667 5x 3- 7.295 5 x 2+3.682 6x+0.567 4 (R 2=0.939 1, n=80, P =0.01), where y is the ratio of SFD of a sensor to the average of four data in different depths, x is the ratio of a sensor depth to the radial sapwood thickness. It was the same (as in the following equation) in Jijia site, y=5.006 2x 3-9.116 1x 2+4.454 4x+0.463 4 (R 2=0.806 9, n=72, P=0.01) in Hetou site. From cambium to heartwood, SFD showed some increases at first and then decreases continuously. However, because the trees were very young, the maximum SFD was only 0.33-0.36 times more than the minimum.