Miracle-dz/UniFAR-FTUs huggingface dataset:
Cloning and characterization of DNA complementary to the canine distemper virus mRNA encoding matrix, phosphoprotein, and nucleocapsid protein

Double-stranded cDNA synthesized from total polyadenylate-containing mRNA, extracted from monkey kidney cells infected with canine distemper virus (CDV), has been cloned into the PstI site of Escherichia coli plasmid pBR322. Clones containing canine distemper virus DNA were identified by hybridization to a canine distemper virus-specific, 32P-labeled cDNA. Four specific clones containing different classes of sequences have been identified. The cloned plasmids contain inserts of 800 (clone 44-80), 960 (clone 74-16), 1,700 (clone 364), and 950 (clone 40-9) base pairs. The sizes of the mRNA species complementary to these inserts are 1,500, 1,850, 1,850 and 2,500 nucleotides, respectively, as determined by the Northern technique. Three of the cloned DNA fragments were further identified as the reverse transcripts of the mRNA coding for the matrix, phosphoprotein, and nucleocapsid protein of CDV.
Interactions among the gypsy transposable element and the yellow and the suppressor of hairy-wing loci in Drosophila melanogaster

We cloned and characterized the yellow locus of Drosophila melanogaster. We also studied its transcription pattern in the suppressible allele y2, which is caused by the insertion of the transposable element gypsy, and the effect of mutations at the unlinked suppressor of Hairy-wing locus on the transcription of yellow RNAs. The gypsy element is transcribed in a temporal fashion that correlates with the pattern of expression of the yellow locus. We propose that the mutational effect of the gypsy element is due to developmentally specific transcriptional interference on yellow transcription. Mutations at the su(Hw) locus reverse this effect by altering the quantitative expression of gypsy.
The ultimate opportunists: consumers of seston

The seston represents a highly dilute food source to potential consumers. Consequently, 3 general prop- erties may be expected of sessile filter feeders: (1) high reten- tion efficiency; (2) possession of a low-energy pump system in active filter feeders; and (3) consumption of seston fractions in proportion to availability (i.e. opportunistic feeding). Whereas the first 2 properties have been well documented, until recently little evidence had been adduced for the third. We assessed whether a pattern across particular studies exists that could provide evidence of opportunistic feeding. Recent studies of the seasonal variation of seston composition and of natural feeding of species representing 3 contrasting feeding modes were reviewed. For the first time, it was possible to demonstrate in the field that sessile filter feeders consume a broad spectrum of seston fractions in proportion to their avail- ability. We conclude that such opportunistic feeding, within phylogenetically determined broad limits, is a general prop- erty of sessile filter feeders, appropriate for exploiting the ubiquitous but dilute and dynamic seston.
Transaction Cost Analysis: Past, Present, and Future Applications

Over the past decade, transaction cost analysis (TCA) has received considerable attention in the marketing literature. Marketing scholars have made important contributions in extending and refining TCA's original conceptual framework. The authors provide a synthesis and integration of recent contributions to TCA by both marketers and scholars in related disciplines, an evaluation of recent critiques of TCA, and an agenda for further research on TCA.
Work‐induced hypertrophy in exercised normal muscles of different ages and the reversibility of hypertrophy after cessation of exercise

1. Groups of male hamsters of different ages were subjected to a weight‐lifting exercise regimen, and the biceps brachii, soleus and extensor digitorum longus (EDL) muscles examined for structural changes occurring in response to the increased workload. In addition, two groups of adult hamsters were left to recover from the exercise stimulus for 5 and 15 weeks respectively.
Evaluation of free radical scavenging activity of morel mushroom, Morchella esculenta mycelia: A potential source of therapeutically useful antioxidants

Cellular damage caused by reactive oxygen species (ROS) has been implicated in several diseases and antioxidants are known to protect the body from this damage. Antioxidants thus, have gained significant importance in human health. The search for effective, non-toxic natural compounds with antioxidant activity has intensified in recent years. Mycelia of a number mushrooms have recently been successfully used for the development of novel pharmaceutical products. We examined the aqueous-ethanol extract of cultured mycelia of the morel mushroom, Morchella esculenta (L.) Pers. (Morchellaceae) for its ability to scavenge super oxide, hydroxyl, nitric oxide, 2,2′-diphenyl-1-picrylhydrazyl (DPPH), and 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) radicals as well as for inhibition of lipid peroxidation. The extract efficiently scavenged all these radicals and also inhibited lipid peroxidation. Ferric reducing antioxidant power (FRAP) assay indicated the hydrogen donating capacity of the extract. The pulse radiolysis studies using ABTS and carbonate radical (CO3•-) showed that the extract significantly carried out the decay of these radicals in a concentration-dependent manner. In conclusion, the investigation showed that the morel mushroom mycelium is an excellent source of antioxidants which are capable of imparting protection at different levels. The findings suggest the potential therapeutic use of morel mushroom, M. esculenta mycelia as an efficient antioxidant.
Is there geographical variation in human handedness?

Right‐ and left‐handed individuals are present in all cultures. However, while it is known that handedness is a heritable trait, little is known about how handedness varies between populations—and without this knowledge, the significance of the left/right polymorphism is hard to interpret. We reviewed the literature to assess the extent of geographical variation of throwing or hammering handedness. These two tasks were chosen because they are present in all known cultures (unlike, for example, writing), and make sense within the context of several adaptive theories on the origin of laterality, or maintenance of handedness polymorphism, which state that tool or weapon manipulation are pivotal. A total of 81 samples were found with primary data on throwing or hammering handedness, spanning 14 countries and concerning more than 1,214,000 individuals studied between 1922 and 1998. A global logistic regression was performed to assess the significance of the country of the study, controlling for several potentially confounding variables (date of the study, sex and age of individuals). Country always had a significant effect, consistent with substantial geographical variation of throwing and hammering handedness. Curiously, left‐handedness frequency estimates for a given country were not always consistent across datasets, perhaps due to missing variables, such as educational level or socio‐economic status. Results are discussed in the context of the evolution of handedness and the significance of the current polymorphism.
Minimal residual disease in acute leukemia.

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Acute confusional state developing in a patient taking acyclovir: from the frying pan into the fire.

Acyclovir is widely used in the treatment of herpes virus infections. The most frequent side effects are nausea and vomiting, headache, and diarrhea. Intravenous administration often leads to inflammation and phlebitis at the site of injection. The serious side effects of acyclovir are renal insufficiency, which may be related to precipitation of acyclovir crystals within the tubular lumen or to interstitial nephritis, and neurotoxicity [1]. Neurotoxicity has been described in up to 1% of patients. When confronting a patient with a herpetic infection, the physician may be confounded by neurotoxicity when attempting to distinguish between signs of central nervous system involvement by viral infection and side effects of a medication. In this article we describe one such case and review previous reports.
The Relationship Between Working Capital Management And Profitability: Evidence From The United States

The paper seeks to extend Lazaridis and Tryfonidis’s findings regarding the relationship between working capital management and profitability. A sample of 88 American firms listed on New York Stock Exchange for a period of 3 years from 2005 to 2007 was selected. We found statistically significant relationship between the cash conversion cycle and profitability, measured through gross operating profit. It follows that managers can create profits for their companies by handling correctly the cash conversion cycle and by keeping accounts receivables at an optimal level. The study contributes to the literature on the relationship between the working capital management and the firm’s profitability.
On-Line Smiles: Does Gender Make a Difference in the Use of Graphic Accents?

In the gender-bending world of computer-mediated communication (CMC), is it possible to determine the gender of a message sender from cues in the message? This study addresses the question by drawing on current literature to formulate and test three hypotheses: (i) women use more graphic accents than men do in their CMC, (ii) men use more challenging language in CMC than do women, and (iii) men write more inflammatory messages than do women. Results indicate that only the first hypothesis is partially supported and that women tend to challenge and flame more than do men in this sample group. The authors also discuss implications and pose questions for additional research.
Cardiovascular adjustments to exercise distributed between the upper and lower body.

The present study examined the hemodynamic differences between upper- and lower-body exercise where the total power output (PO) was proportionally distributed between the upper and lower body. Six males completed five combinations of arm-leg exercise at maximal and three submaximal intensities. The ratio of arm PO to total PO for each exercise combination was 0, 25, 50, 75, and 100%. At each submaximal intensity, VO2 and cardiac output (Q) were not different (P greater than 0.05) across exercise combinations. Likewise, heart rate (HR) responses were not different for 0, 25, 50, and 75% at level 1 (mean = 102, 102, 106, 106 beats.min-1, respectively), level 2 (mean = 114, 110, 119, 118 beats.min-1, respectively), and level 3 (mean = 127, 124, 132, 131 beats.min-1, respectively). However, HR for 100% (arm-only exercise) tended to be higher than 0% at level 1 (delta HR = 10 beats.min-1; P less than 0.10), level 2 (delta HR = 12 beats.min-1, P less than 0.06) and level 3 (delta HR = 10 beats.min-1; P less than 0.06). At level 1, stroke volume (SV) remained essentially unchanged from 0-75%, while SV at 100% (108 ml) was slightly though not significantly lower (P less than 0.10) than 0% (125 ml). At exercise levels 2 and 3, SV remained unchanged for 0 and 25%; however, SV at 50, 75, and 100% were generally lower (P less than 0.05) compared with 0%. These results indicate that involving the leg musculature to varying degrees during arm-leg exercise attenuates the hemodynamic differences observed during strict upper body versus strict lower body exercise.
Safety and tolerability of antipsychotic co-treatment in patients with schizophrenia: results from a systematic review and meta-analysis of randomized controlled trials

ABSTRACT Introduction: Antipsychotic co-treatment is common in schizophrenia, despite lacking evidence for its efficacy and safety. Areas: We conducted a systematic search of PubMed/PsycInfo/CJN/WangFan/CBM without language restrictions from database inception until 05/25/2015 for randomized trials comparing antipsychotic monotherapy with antipsychotic co-treatment in ≥20 adults with schizophrenia reporting meta-analyzable adverse events (AEs) data. Meta-analyzing 67 studies (n=4,861, duration=10.3±5.2 weeks), antipsychotic co-treatment was similar to monotherapy regarding intolerability-related discontinuation (risk ratio (RR)=0.84, 95% confidence interval (CI)=0.53-1.33, p=0.455). While incidence of ≥1 AE was lower with antipsychotic co-treatment (RR=0.77, 95%CI=0.66-0.90, p=0.001), these results were solely driven by open-label and efficacy-focused studies. Adjunctive D2-antagonists lead to less nausea (RR=0.220, 95%CI=0.06–0.87, p=0.030) and insomnia (RR=0.26, 95%CI=0.08-0.86, p=0.028), but higher prolactin (SMD=2.20, 95%CI=0.43-3.96, p=0.015). Conversely, adjunctive partial D2-agonists (aripiprazole=100%) resulted in lower electrocardiogram abnormalities (RR=0.43, 95%CI=0.25-0.73, p=0.002), constipation (RR=0.45, 95%CI=0.25-0.79, p=0.006), drooling/hypersalivation (RR=0.14, 95%CI=0.07-0.29, p<0.001), prolactin (SMD=-1.77, 95%CI=-2.38, -1.15, p<0.001), total and LDL-cholesterol (SMD=-0.33, 95%CI=-0.55, -0.11, p=0.003; SMD=-0.33, 95%CI=-0.54, -0.10, p=0.004). Expert opinion: No double-blind evidence for altered AE burden associated with antipsychotic co-treatment was found. However, AEs were insufficiently and incompletely reported and follow-up duration was modest. Adjunctive partial D2-agonists might be beneficial for counteracting several AEs. High-quality, long-term studies that comprehensively assess AEs are needed.
The Impact of Allopurinol on Patients With Acute ST Elevation Myocardial Infarction Undergoing Thrombolytic Therapy

Abstract: Allopurinol may have protective effects over ischemic reperfusion injury and reduce infarct size. In this randomized study, we aimed to evaluate the impact of allopurinol in patients with acute ST elevation myocardial infarction (STEMI) undergoing thrombolytic therapy. Overall, 140 patients with STEMI were randomly assigned to receive 400 mg of allopurinol or placebo before treating with streptokinase. Then, study group received 100 mg of allopurinol daily for 28 days and placebo group received placebo for the same period. ST resolution rate in 90 minutes, in-hospital mortality, and major adverse cardiac events (MACE) were compared. Compared to placebo group, patients receiving allopurinol had significantly higher rate of ST resolution rate ≥50% (68.8% vs. 50%, P = 0.04) and lower levels of peak Creatine kinase (CK) (P = 0.003), Creatine Kinase-MB (CK-MB) (P = 0.005), and Cardiac Troponin I (CTnI) (P < 0.001). Also, patients in allopurinol group had significantly lower rate of in-hospital MACE (P = 0.03), but there was no significant difference between groups regarding in-hospital mortality and cardiac events. In patients admitted with STEMI who are candidates of thrombolytic therapy, allopurinol is associated with better 90-minute ST resolution, lower enzymatically determined infarct size, and in-hospital MACE. More powerful studies are needed to determine the effect on mortality.
The short-term efficacy of dilatation therapy combined with steroid after internal urethrotomy in the management of urethral stenoses.

PURPOSE To present the short-term results of hydrophilic dilatation catheter or steroid-coated hydrophilic dilatation catheter usage in the management of primary urethral stricture. PATIENTS AND METHODS Forty-five male patients with a diagnosis of primary urethral stricture shorter than 1.5 cm and no comorbities were included in this study. After application of visual internal uretrotomy interna, these patients were randomized into three groups. A steroid-coated (triamcinolone acetonide 1%) 18F hydrophilic dilatation catheter was applied to the patients in group 1 for 2 weeks and an 18F hydrophilic dilatation catheter was applied to the patients in group 2 for 2 weeks. An 18F silicone urethral catheter was applied to the patients in group 3, and catheters were removed after 3 days. Uroflowmetry was used in postoperative follow-ups. RESULTS Mean patient age and follow-ups were 33.4 (19-45) years and 16.4 (6-18) months, respectively. The postoperative maximum urinary flow rate was 15.3 +/- standard deviation (SD) 4.6, 13.8 +/- SD 4.8, and 12.4 +/- SD 4.4 for groups 1, 2, and 3, respectively (P 0.323). Failure was detected in three (20%) patients in group 1, seven (46.7%) patients in group 2, and nine (60%) patients in group 3 (P > 0.05). CONCLUSIONS As an adjuvant treatment, this method is effortless, low in complications, and hopeful. Certainly, application to larger patient populations is needed to objectively accept its efficiency.
Reduced susceptibility to permethrin and its relationship to DDT resistance in larvae of Anopheles stephensi

Abstract. Permethrin selection of DDT resistant Anopheles stephensi Liston mosquito larvae produced a reduction in susceptibility to knockdown (2 h exposure) of 17‐fold, but only 1.6‐fold to kill (24 h exposure). Genetic analysis, incorporating visible mutant markers, was interpreted as indicating that, through multigenic inheritance, several interacting genetic factors were collectively responsible for reduced larval susceptibility to knockdown. These were maintained together only under selection pressure, as the effect was lost quickly in the absence of selection or with outcrossing. The 30–40‐fold DDT‐resistance found in the parental strain was barely altered by permethrin selection, suggesting no relationship with the major source of DDT resistance. This was confirmed in single family studies. Some evidence for an additional tolerance to DDT was found to be associated with reduced larval susceptibility to permethrin.
Cervical Hibernoma Demonstrating Uptake on Tc-99m Lymphoscintigraphy

A hibernoma is an uncommon, benign tumor composed of brown adipose tissue. It is a rare but documented cause of neck masses. Hibernomas may be first diagnosed not by clinical examination, but incidentally through radiologic tests assessing the metabolic activity of certain tissues. These tumors are by definition benign entities but, given their propensity for growth over time, they require complete extirpation to prevent recurrence. Different radiologic modalities have been used to evaluate hibernomas, including computed tomography scan, magnetic resonance imaging, fluorine-18 fluoro-2-deoxy-D-glucose positron emission tomography, and angiography. It is rare for a hibernoma to be discovered through Tc-99m lymphoscintigraphy.
Sex steroid hormone exposures and risk for meningioma.

OBJECT The goal of this study was to investigate the risk of meningioma in relation to exogenous and endogenous sex hormones. METHODS The study participants were female registered nurses from 11 US states who were between 30 and 55 years of age when they enrolled in the Nurses' Health Study cohort. These women completed biennial questionnaires between 1976 and 1996. All participants were free from cancer and other major medical illness at the onset of the study. The primary endpoint was meningioma as self-reported in biennial and supplemental questionnaires. During 1,213,522 person-years of follow-up review, 125 cases of meningioma were confirmed. After adjusting for age and body mass index (BMI), compared with postmenopausal women who had never used postmenopausal hormones, the relative risk (RR) for premenopausal women was 2.48 (95% confidence interval [CI] 1.29-4.77; p = 0.01) and the RR for postmenopausal women who received hormone therapy was 1.86 (95% CI 1.07-3.24; p = 0.03). The authors found no excess risk associated with past hormone use. In models that additionally controlled for hormone use and menopausal status, the authors found that, compared with women whose menarche occurred before they were 12 years of age, the RR for women whose menarche occurred at ages 12 through 14 years was 1.29 (95% CI 0.86-1.92; p = 0.21) and the RR for women whose menarche occurred after age 14 years was 1.97 (95% CI 1.06-3.66; p = 0.03). The authors also observed a tendency, albeit nonsignificant, for increased risk of meningioma in parous as opposed to nulliparous women (multivariate RR = 2.39, 95% CI 0.76-7.53; p = 0.14). A trend toward an increasing risk of meningioma with increasing BMI was also noted (p for trend = 0.06). No association was found for past or current use of oral contraceptives. CONCLUSIONS The risk for meningiomas was increased among women exposed to either endogenous or exogenous sex hormones. An unexpected relationship with increasing age at menarche was also noted; this remains unexplained.
Components of Developmental Care and the Evidence for Their Use in the NICU

Developmental care, a philosophy of care that requires rethinking the relationships between infants, families, and healthcare providers, is in place in the majority of neonatal intensive care units in the United States. Developmental care includes a variety of activities designed to manage the environment and individualize the care of the premature infant based on behavioral observations. The goal is to promote a stable, well-organized infant who can conserve energy for growth and development. Research about the effects of developmental care has shown a trend toward improved short-term physiologic, development, and resource utilization outcomes for infants up to 24 months of age, but benefits beyond this age are unclear. Most of the research has focused on developmental care as a whole, but there is also strong scientific evidence for specific components of developmental care. The NICU care provider should use developmental care interventions that are clearly supported by evidence, and use others based on judgment and the infant’s responses.
Understanding Gender Differences in Leadership

Using data from a large-scale field experiment, we show that while there is no gender difference in the willingness to make risky decisions on behalf of a group in a sample of children, a large gap emerges in a sample of adolescents. The proportion of girls who exhibit leadership willingness drops by 39% going from childhood to adolescence. We explore the possible factors behind this drop and find that it is largely associated with a dramatic decline in “social confidence”, measured by the willingness to perform a real effort task in public.
Rapostlin Is a Novel Effector of Rnd2 GTPase Inducing Neurite Branching*

Rho family GTPases are central regulators of neuronal morphology. Recently, Rnd proteins, Rnd1, Rnd2, and Rnd3/RhoE, have been identified as new members of Rho family GTPases. Of these, Rnd2 is specifically expressed in neurons in brain; however, the signaling pathways of Rnd2 are not known. Here we have performed a yeast two-hybrid screen using Rnd2 as a bait and identified a novel Rnd2-effector protein, expressed predominantly in brain. We named it Rapostlin (apostle of Rnd2). Rapostlin has two functional domains, Fer-CIP4 homology (FCH) domain at the amino terminus and SH3 (Src homology 3) domain at the carboxyl terminus. In in vitro binding assays, Rapostlin specifically binds to Rnd2 among the Rho family GTPases in a GTP-dependent manner, and the Rnd2-binding domain of Rapostlin is localized between FCH and SH3 domains. Rapostlin directly binds to microtubules, and the amino-terminal region containing the FCH domain of Rapostlin is essential for this interaction. In PC12 cells, Rapostlin induces neurite branching in response to Rnd2, and at least the amino-terminal region of Rapostlin is necessary for this activity. Therefore, Rapostlin is the first effector of Rnd2, regulating neurite branch formation.