Miracle-dz/UniFAR-FTUs huggingface dataset:
Methylphenidate and Interpersonal Relationships of Children with Attention Deficit Hyperactivity Disorder

Abstract: In order to clarify the effects of methylphenidate on interpersonal relationships of children with attention deficit hyperactivity disorder (ADHD), data from sociometric tests conducted in 28 classes to which ADHD children belonged was analyzed, comparing patients who had a history of methylphenidate treatment with those who had not. It was suggested that ADHD children with a history of methylphenidate treatment had more favorable votes and fewer unfavorable ones than those without it. However, there were more isolated children among ADHD children with methylphenidate treatment than in those without it. The results are discussed in the light of previous findings in the literature and a hypothesis for methylphenidate induced isolation is proposed.
Predictors of Moderate or Severe Pain 6 Months After Orthopaedic Injury: A Prospective Cohort Study

Objective: To determine predictors of moderate or severe pain 6 months after orthopaedic injury. Design: Prospective cohort study. Setting: Two adult level 1 trauma centers in Victoria, Australia. Participants: A total of 1290 adults admitted with orthopaedic injuries and registered by the Victorian Orthopaedic Trauma Outcomes Registry. Main Outcome Measures: Participant self-reported pain and health status using an 11-point numerical rating scale and the 12-item Short-Form health survey, respectively. Results: The prevalence of moderate or severe pain was 48% [95% confidence interval (CI), 45-51] at discharge and 30% (95% CI, 28-33) at 6 months postinjury. Failure to complete high school [adjusted odds ratio (AOR) 1.5 (95% CI, 1.1-1.9)], self-reported preinjury pain-related disability [AOR 1.8 (95% CI, 1.3-2.5)], eligibility for compensation [AOR 2.1 (95% CI, 1.6-2.8)], and moderate or severe pain at discharge from the acute hospital [AOR 2.4 (95% CI, 1.8-3.1)] were found to be independent predictors of moderate or severe pain at 6 months postinjury. Conclusions: Moderate or severe pain is commonly reported 6 months after orthopaedic trauma. Pain intensity at discharge and the effects of a “no-fault” compensation system are potentially modifiable factors that might be addressed through intervention studies to reduce the burden of persistent pain after orthopaedic trauma.
Annexins – unique membrane binding proteins with diverse functions

Annexins are a well-known multigene family of Ca2+-regulated phospholipid-binding and membrane-binding proteins. Recent work employing annexin-knockdown or - knockout models has provided new insights into the biological functions of different annexin proteins. Transient annexin depletion by RNA interference and the expression of dominant-negative mutant proteins has revealed roles for the proteins in membrane processes ranging from the control of membrane structure to certain membrane transport phenomena. Although such functions correlate well with the ability of annexins to interact with cellular membranes in a reversible and regulated manner, some activities are membrane independent, probably because annexins can also engage in specific protein-protein interactions. Among other things, this is evident in annexin A1- and A2-knockout mice, which show impaired regulation of neutrophil extravasation and defects in plasmin generation, respectively.
MIMO antenna with cross polarisation printed yagi elements for MIMO router

Low spatial correlation will increase the capacity of MIMO systems. In the MIMO antenna design, a low spatial correlation needs to be considered in supporting the maximum capacity. In this paper an 8 elements MIMO antenna was proposed and investigated for multiuser MMO router with 5 GHz frequency operation. Printed Yagi is used as an antenna element of the proposed MIMO antenna. In order to achieve low spatial correlation, cross-polarization arrangement between adjacent elements in proposed MIMO antenna is investigated to minimize coupling level. Numerical investigation has been conducted. The results show that the proposed antenna has cover large bandwidth around 5 GHz, from 4.54 GHz to 5.51 GHz with low return loss at 5 GHz. The cross polarization scenario successfully reduces the coupling level and produces the highest coupling level is −37 dB.
Social support and self-care activities among the elderly patients with diabetes in Kelantan.

INTRODUCTION Diabetes is common among the elderly and can significantly affect their lives including the issues related with social support and diabetic self-care activities. OBJECTIVES The objective of this study was to examine the social support and self-care activities among the elderly patients with diabetes. METHODS A survey involving 200 patients was conducted from March 2013 to May 2013 in three hospitals in Kelantan. Data were obtained through self-administered questionnaires and clinical characteristics were acquired from the patients' records. RESULTS The scores for social support (mean = 19.26; SD = 2.63) and self-care activities (mean = 14.83; SD = 4.92) were moderate. Higher social support was associated with high levels of glycated haemoglobin (HbA1c), fasting blood sugar (FBS) level, the duration of diabetes and a decrease in body mass index (BMI) (p<0.05). It was observed that the patients with low educational, Hb1Ac and FBS level, with other chronic diseases and who have had diabetes for some time had low self-care activities (p<0.05). There was a significant negative relationship between an increase in social support and decrease in self-care activity (p<0.05). CONCLUSION Healthcare providers, family and friends have to strengthen their relationship with the elderly patients with diabetes to provide more social support and promote the compliance with diabetic self-care activities to improve clinical outcomes.
Transperitoneal laparoscopic repair of iatrogenic vesicovaginal fistulas: Heilbronn experience and review of the literature.

BACKGROUND AND PURPOSE Vesicovaginal fistula (VVF) continues to be a distressing problem in urogynecology. Laparoscopy has become increasingly popular in the field of reconstructive urologic surgery. We describe our technique of laparoscopic VVF repair for iatrogenic VVFs, discuss our technique and outcomes, and review the related literature. PATIENTS AND METHODS After hysterectomy for a benign condition, an iatrogenic VVF developed in three women (41, 48, and 34 years old, respectively) that persisted despite conservative therapy. Preoperative urethrocystoscopy demonstrated supratrigonal VVFs. Laparoscopic surgery was performed for the three patients after 3, 8, and 4 months of the previous abdominal operations. Patients were placed in a deflected supine position, and a transperitoneal five-port approach was used. The bladder was bivalved, and the fistula tract was excised. The fistulous tract was successfully repaired by closing the vagina and bladder separately. An interposing peritoneal flap was placed and fixed between the bladder and vagina. RESULTS The patients recovered uneventfully and were discharged from the hospital after 4, 9, and 5 days, respectively. Retrograde cystography on postoperative day 10 revealed no contrast leakage via the vagina. The urethral catheters were removed on the same day. After 30, 17, and 14 months of follow up, respectively, the patients were voiding without any urine leakage. CONCLUSIONS Laparoscopic repair can be applied effectively in the management of VVFs. The approach is safe and provides all advantages of minimally invasive surgery. Shorter hospital stay and shorter recovery time have a positive effect on the patients' well being.
A phylotypic stage in vertebrate brain development: GABA cell patterns in zebrafish compared with mouse

A recent comparison of early forebrain gene expression in mouse and zebrafish revealed highly comparable expression patterns of developmentally relevant genes, for example, of proneural (Neurogenin1, NeuroD, Mash1/Zash1a) genes involved in neurogenesis at a particular time window (mouse: embryonic day 12.5/13.5; zebrafish: 3 days). Here we extend this analysis to the description of γ‐aminobutyric acid (GABA) cell patterns in the early postembryonic zebrafish brain (i.e., during early secondary neurogenesis). We find again an astonishing degree of correspondences of GABA cell patterns between zebrafish and mouse during this previously established critical time window, for example, regarding absence of GABA cells in certain forebrain regions (pallium, dorsal thalamus, eminentia thalami) or with respect to the spatiotemporal occurrence of GABA cells (e.g., late cerebellar GABA cells). Furthermore, there is perfect correlation with previously established proneural gene expression patterns (i.e., absence of Mash1/Zash1a gene expression in GABA‐cell‐free forebrain regions) between mouse and zebrafish. The available information in additional vertebrate species, especially in Xenopus, is also highly consistent with our analysis here and suggests that a “phylotypic stage” of neurogenesis during vertebrate brain development may be present. J. Comp. Neurol. 494:620–634, 2006. © 2005 Wiley‐Liss, Inc.
Identification of IgE and IgG1 specific antigens in Echinococcus granulosus cyst fluid

Cystic echinococcosis (CE) is an anthropozoonotic disease with worldwide distribution and is caused by the cestode Echinococcus granulosus. Anaphylactic shock induced by CE rupture is a serious complication especially in patients with hydatid infections, as the resulting leakage of fluid contains highly toxic endogenous antigen. We aimed to isolate and identify the antigens of specific IgE and IgG1 (sIgE and sIgG1) in E. granulosus cyst fluid (EgCF). Crude antigen for EgCF was prepared from E. granulosus-infected sheep liver. Antigens were separated and identified by one-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis (1D SDS-PAGE), two-dimensional gel electrophoresis (2-DE), and immunoblotting. Results of 1D SDS-PAGE and immunoblotting showed that 40.5 kDa protein was the major antigen of sIgE, and 35.5 kDa protein was the major antigen of sIgG1 in EgCF. Results of 2-DE and immunoblotting showed that main antigens of sIgE in EgCF were four proteins with pI values ranging from 6.5 to 9.0 and a molecular weight of 40.5 kDa. Main antigens of sIgG1 in EgCF were five proteins with pI values ranging from 6.5 to 9.0 and a molecular weight of 35.5 kDa. The antigens identified for sIgE and sIgG1 can provide critical insights into cellular and molecular mechanisms underlying anaphylactic shock induced by CE.
Effect of nitrogen and irrigation on water use, moisture-extraction pattern, nutri- ent uptake and yield of fennel (Foeniculum vulgare)

A field experiment was conducted during the winter seasons of 2001-03 at Agricultural Research Station, Sriganganagar, Rajasthan, to study the water use, nutrient uptake, yield and economics of fennel (Foeniculum vulgare Mill.) cultivars under vrious levels of nitrogen and irrigations. The highest yield (25.16 and 19.04 qlha) and yield attributes were recorded with 80 kg Nlha. Net returns and gross returns and benefit : cost ratio were also the highest at 80 kg Nlha. lncreasing levels of nitrogen also recorded higher consumptive use of water and significantly higher nutrients uptake. Higher level of nitrogen extracted more water from lower depth of rhizosphere than lower level of N. With an increase in irrigation frequency from IW : CPE ratio 0.4 to 0.8, yield and most of the yield at- tributes increased significantly. Similarly, water use and nutrients uptake were also higher with higher levels of irri- gation. At lower irrigation level (IW : CPE ratio 0.4) more water was extracted from upper layers than higher irriga- tion level. lncreasing levels of irrigation also recorded higher gross, net returns and benefit : cost ratio. Between the 2 varieties, 'RF 125' outperformed 'RF 101'.
Imatinib and Nilotinib induce apoptosis of chronic myeloid leukemia cells through a Bim-dependant pathway modulated by cytokines

It is an important challenge to better understand the mechanisms of tyrosine kinase inhibitors-induced apoptosis in CML cells. Thus, we have investigated how this apoptosis can be modulated by extracellular factors. Apoptosis induced by imatinib and nilotinib was determined in BCR-ABL expressing cell lines and primary CML CD34+ cells. Both molecules induced apoptosis of BCR-ABL expressing cells. This apoptosis was inhibited by protein synthesis inhibition in both K562 and CML CD34+ cells. In K562, 80% inhibition of the BCR-ABL auto-phosphorylation by either imatinib or nilotinib induced a two fold increase in Bim-EL expression and induction of apoptosis in 48h. Bim accumulation preceded apoptosis induction and was completely abolished by depletion in Bim using shRNA. However, the anti-proliferative effect of imatinib was preserved in Bim-depleted cells. When K562 cells were cultured in a cytokine containing medium, the pro-apoptotic effect of nilotinib was decreased by 68% and this was related to a decrease in Bim-EL de-phosphorylation and accumulation. Similarly, the presence of a combination of cytokines inhibited 88% of NIL- and 39% of IMA-induced apoptosis in primary CML CD34+ cells. In conclusion, both nilotinib and imatinib induce apoptosis through Bim accumulation independently of cell cycle arrest. However, the pro-apoptotic effect of both molecules can be attenuated by the presence of cytokines and growth factors, particularly concerning nilotinib. Thus BCR-ABL inhibition restores the cytokine dependence but is not sufficient to induce apoptosis when other signaling pathways are activated.
Large Size Czochralski Growth and Scintillation Properties of $\text{Mg}^{2+}$ Co-doped $\text{Ce}:\text{Gd}_{3}\text{Ga}_{3}\text{Al}_{2}\text{O}_{12}$

The 3 inch size Mg co-doped Ce : Gd<sub>3</sub>Al<sub>2</sub>Ga<sub>3</sub>O<sub>12</sub> single crystals were prepared by the Czochralski (Cz) method. Absorption and luminescence spectra were measured together with several other scintillation characteristics, namely the scintillation decay and light yield to reveal the effect of Mg co-doping. The timing resolution measurement for a pair of 3 × 3 × 3 mm<sup>3</sup> size GAGG:Ce.Mg scintillator crystals was performed using Si-PMs.
Exploring just sustainability across the disciplines at one university

Abstract We examined The University of Vermont’s new sustainability requirement for undergraduates through the lens of just sustainability. We found that sustainability courses are proposed in diverse disciplines. Regardless of discipline, most proposed courses address all three pillars of sustainability (social, ecological, and economic). Discussions of environmental justice are less widespread; only 17% of proposed courses in science, technology, and math departments addressed environmental justice. Our results provide examples for others interested in integrating sustainability across diverse disciplines and in emphasizing environmental justice. We also call attention to the fact that institutions of higher education may need explicit reminders or requirements to adequately include considerations of environmental justice in sustainability studies.
Genetics of a reintroduced swift fox population highlights the need for integrated conservation between neighbouring countries

The genetic consequences of reintroductions are rarely considered after releases cease, but long‐term viability depends on linked demography and genetic health. Reintroductions of swift foxes Vulpes velox began after 45 years of extirpation from Canada; these have resulted in national down‐listing to ‘threatened’ status, and the re‐establishment of a small contiguous population in Montana, US. Demographic growth has been associated with stable levels of genetic diversity and growing effective population size, but evidence of two genetic clusters, and a recent decline in abundance could be cause for conservation concern depending on underlying mechanisms. We analysed individuals from two time points at 18 microsatellite loci to investigate whether the genetic structure is a consequence of having used two separate release sites and non‐equilibrium population dynamics, but our results suggest that the population is likely at mutation‐ and migration‐drift equilibrium. We examined habitat effects on relative gene flow and found limited evidence for cropland to be a dispersal barrier, but effects of terrain roughness suggest that more rugged landscapes may reduce dispersal capacity. Using parentage analysis we determined maximum dispersal distances of up to 50 km for females and 100 km for males including movements in either direction across the international border, but no mixing of genetic clusters was seen in either country. Greater genetic connectivity among than within respective countries necessitates careful co‐management between Canada, where the species has the highest levels of legislative protection, and contiguous areas of the United States where limited trapping for fur is now permitted. We encourage similar analyses of conservation populations across international borders to determine how optimal genetic management can best mesh with different policies and conservation approaches among countries.
Downregulation of Class I Major Histocompatibility Complex Surface Expression by Varicella-Zoster Virus Involves Open Reading Frame 66 Protein Kinase-Dependent and -Independent Mechanisms

ABSTRACT We show here that the varicella-zoster virus (VZV) open reading frame 66 (ORF66) protein kinase is one mechanism employed to reduce class I major histocompatibility complex (MHC-I) surface expression in VZV-infected cells. Cells expressing enhanced green fluorescent protein-tagged functional and inactivated ORF66 (GFP-66 and GFP-66kd) from replication-defective adenovirus vectors revealed that ORF66 reduced MHC-I surface levels in a manner dependent on kinase activity. Cells infected with recombinant VZV expressing GFP-66 exhibited a significantly greater reduction in MHC-I surface expression than that observed in cells infected with VZV disrupted in GFP-66 expression. MHC-I maturation was delayed in its transport from the endoplasmic reticulum through the Golgi in both adenovirus-transduced cells expressing only GFP-66 and in VZV-infected cells expressing high levels of GFP-66, and this was predominantly kinase dependent. MHC-I levels were reduced in VZV-infected cells, and analyses of intracellular MHC-I revealed accumulation of folded MHC-I in the Golgi region, irrespective of ORF66 expression. Thus, the ORF66 kinase is important for VZV-mediated MHC-I downregulation, but additional mechanisms also may be involved. Analyses of the VZV ORF9a protein, the ortholog of the bovine herpesvirus 1 transporter associated with antigen processing inhibitor UL49.5 revealed no effects on MHC-I. These results establish a new role for viral protein kinases in immune evasion and suggest that VZV utilizes unique mechanisms to inhibit antigen presentation.
A Systematic Review and Meta-analysis of Retrospective Series of Regorafenib for Treatment of Metastatic Colorectal Cancer.

BACKGROUND Metastatic colorectal cancer is a common disease encountered in oncology practice and treatment options beyond fluoropyrimidines, irinotecan, oxaliplatin and monoclonal antibodies against epidermal growth factor receptor and vascular endothelium growth factor (VEGF) are limited. Regorafenib, a new drug that targets tyrosine kinases such as VEGF receptor as well as others, has been added recently to the armamentarium for metastatic colorectal cancer. This report analyzes the published experience with this drug in clinical practice outside of clinical trials. MATERIALS AND METHODS A literature search of major databases was performed for the identification of studies of regorafenib in metastatic colorectal cancer. Studies retained for further analysis were in English or French, describing 20 or more patients treated with regorafenib monotherapy and not part of a phase I, II or III trial. Results of the pooled analysis of retrospective studies were compared with results of the published phase III trials and a phase IIIb prospective study. RESULTS Twelve publications including a total of 702 patients were included in the meta-analysis. Summary response rate was 2% [95% confidence interval (CI) =0.8-3.2%] and the disease control rate 38.14% (95% CI=32.35-43.93%). Summary survival rates were 3.34 months (95% CI=2.71-3.97 months) for progression-free and 7.27 months (95% CI=6.23-8.3 months) for overall survival. These were similar to the phase III and IIIb studies. Most common adverse effects were also consistent with those of the published phase III experience. CONCLUSION This systematic review and meta-analysis confirmed a moderate efficacy of regorafenib in later-stage metastatic colorectal cancer in the everyday clinical practice setting outside of clinical trials. Future identification of biomarkers may aid in further tailoring of this treatment in order to obtain maximum clinical benefit.
Agency-Based Male Sex Work: A Descriptive Focus on Physical, Personal, and Social Space

Thirty male sex workers (MSWs) from a single agency participated in a qualitative interview about social and occupational aspects of their lives. MSWs established physical (defined areas where clients were not invited) and psychological (limitations of relationship with clients, other escorts, and the agency manager) boundaries to construct personal and professional space regarding sex work. Physical and psychological boundaries often were blended (e.g., bringing friends/family to the agency, utilizing the agency as a “drop-in community center”). The agency further mitigated negative aspects of sex work by providing job training, social support, stigma management, and dual-use space. Actors co-created a context wherein business could be conducted while meeting MSWs' psychosocial needs.
Results of Intraoperative 5‐Fluorouracil or Lower Dose Mitomycin‐C Administration on Initial Trabeculectomy Surgery

Purpose:This study was conducted to review outcomes in eyes following primary trabeculectomy supplemented intraoperatively with 5-fluorouracil (5-FU) or lower dose mitomycin-C (MMC). Patients and Methods:We retrospectively reviewed the medical records of 73 eyes of 63 patients with progressive, far advanced open angle glaucoma who had undergone initial trabeculectomy with intraoperative application of 5-FU, 50 mg/mL for 5 min (N = 37), or MMC, 200 μ/mL for 3–5 min (N = 36), and with at least 12 months follow-up. Results:Mean preoperative intraocular pressures (IOPs) in the MMC and 5-FU groups were 24.3 ± 7.6 and 24.6 ± 9.3 mm Hg, respectively. Postoperatively, IOPs were similar at 6-month interval follow-up examinations in the MMC and 5-FU groups. At an average follow-up of 20.9 months, mean final visit postoperative IOPs were 10.2 ± 3.6 (p < 0.001) and 9.7 ± 3.4 mm Hg (p < 0.001) in the MMC and 5-FU groups, respectively, requiring an average of 0.25 and 0.22 antiglaucoma medications per eye, respectively. Interval follow-up complications were similar between groups and included four bleb leaks in the MMC group, and three bleb leaks in the 5-FU group. Visual acuity remained stable in 71 of 73 eyes. Conclusions:Both antifibrosis agents provide good intermediate term IOP control and may be appropriate for use in those eyes requiring final “target” IOPs in the low teens or single digits.