Miracle-dz/UniFAR-FTUs huggingface dataset:
The crystal structure of dichlorido(1,3-bis(2,6-diisopropyl-phenyl)-1H-3λ4-imidazol-2-yl)(3-phenyl-pyridine-κN)palladium(IV), C38H45N3Cl2Pd

Abstract C38H45N3Cl2Pd, monoclinic, P21/c (no. 14), a = 12.8249(8) Å, b = 16.0552(9) Å, c = 20.5611(10) Å, β = 115.396(3)°, V = 3824.5(4) Å3, Z = 4, Rgt(F) = 0.0287, wRref(F2) = 0.0879, T = 173(2) K.
Evaluation of a type 2 diabetes prevention program using a commercial weight management provider for non-diabetic hyperglycemic patients referred by primary care in the UK

Objectives To determine if a diabetes prevention program (DPP) delivered by a commercial weight management provider using a UK primary care referral pathway could reduce the progression to type 2 diabetes (T2D) in those diagnosed with non-diabetic hyperglycemia (NDH—being at high risk of developing T2D). Research design This is a quasi-experimental translational research study. Methods 14 primary care practices identified, recruited and referred patients with NDH (fasting plasma glucose ≥5.5 to ≤6.9 mmol/L and/or glycated hemoglobin (HbA1c) ≥42 to 47 mmol/mol (6.0%–6.4%)) and a body mass index (BMI) ≥30 kg/m2 to a DPP. Eligible patients were asked to contact Weight Watchers to book onto their DPP, an intensive lifestyle intervention which included a 90 min activation session followed by the offer of 48 weekly Weight Watchers community group meetings. Patients’ blood tests were repeated by primary care, weight change plus self-reported data was recorded by Weight Watchers. Results 166 patients were referred to the program and 149 were eligible. 79% of eligible patients attended an activation session (117 eligible patients) and 77% started the weekly sessions. The study sample was primarily female (75%), white (90%), with 5% living in the most deprived quintile in the UK. Using intention-to-treat analysis, the DPP resulted in a mean reduction in HbA1c of 2.84 mmol/mol at 12 months (from 43.42±1.28 to 40.58±3.41, p<0.01). 38% of patients returned to normoglycemia and 3% developed T2D at 12 months. There was a mean weight reduction in BMI of 3.2 kg/m2 at 12 months (35.5 kg/m2±5.4 to 32.3 kg/m2±5.2, p<0.01). Conclusion A UK primary care referral route partnered with this commercial weight management provider can deliver an effective DPP. The lifestyle changes and weight loss achieved in the intervention translated into considerable reductions in diabetes risk, with an immediate and significant public health impact.
Effects of radiation therapy on bone lesions as measured by 47 Ca and 85 Sr local kinetics.

The presence of osseous mÃ©tastasesmay be de tected by the use of bone scan as a result of the increased deposition of bone-seeking radionuclides in those areas (7,2). Little is known, however, about the local kinetics of these nuclides in the diseased portions of the skeleton following radiation therapy of these bone mÃ©tastases.
Analysis of the replicon region and identification of an rRNA operon on pBM400 of Bacillus megaterium QM B1551

An 18 633 bp region containing the replicon from the ≈ 53 kb pBM400 plasmid of Bacillus megaterium QM B1551 has been sequenced and characterized. This region contained a complete rRNA operon plus 10 other potential open reading frames (ORFs). The replicon consisted of an upstream promoter and three contiguous genes (repM400, orfB and orfC) that could encode putative proteins of 428, 251 and 289 amino acids respectively. A 1.6 kb minimal replicon was defined and contained most of repM400. OrfB was shown to be required for stability. Three 12 bp identical tandem repeats were located within the coding region of repM400, and their presence on another plasmid caused incompatibility with their own cognate replicon. Nonsense, frameshift and deletion mutations in repM400 prevented replication, but each mutation could be complemented in trans. RepM400 had no significant similarity to sequences in the GenBank database, whereas five other ORFs had some similarity to gene products from other plasmids and the Bacillus genome. An rRNA operon was located upstream of the replication region and is the first rRNA operon to be sequenced from B. megaterium. Its unusual location on non‐essential plasmid DNA has implications for systematics and evolutionary biology.
On the relationship between negative affective priming and prefrontal cognitive control mechanisms

Although several studies have examined inhibition of affective stimuli, valence-dependent cognitive control effects remain poorly understood. Behavioural and functional imaging (functional magnetic resonance imaging) data were collected from 17 healthy participants to examine neural correlates of the Negative Affective Priming (NAP) task. We created relative ratio scores considering the reaction times of prime trials in order to assess the amount of interference after the presentation of negative and positive distracter words. Behavioural results showed an attenuated NAP effect for negative distracters compared to neutral stimuli. Furthermore, priming negative distracters generated more interference by reacting to the probe target than positive distracters. Neuroimaging data revealed a stronger prefrontal activation during negative NAP trials compared to positive NAP and neutral control trials, which was reflected in a heightened activation of superior and middle frontal gyrus as well as parietal cortex. The findings show the impact of negative distracters on prefrontal response, contributing to the understanding of NAP effects in healthy subjects.
Human Eosinophils and Human High Affinity IgE Receptor Transgenic Mouse Eosinophils Express Low Levels of High Affinity IgE Receptor, but Release IL-10 upon Receptor Activation

FcεRI expressed by human eosinophils is involved in IgE-mediated cytotoxicity reactions toward the parasite Schistosoma mansoni in vitro. However, because receptor expression is low on these cells, its functional role is still controversial. In this study, we have measured surface and intracellular expression of FcεRI by blood eosinophils from hypereosinophilic patients and normal donors. The number of unoccupied receptors corresponded to ∼4,500 Ab binding sites per cell, whereas 50,000 Ab binding sites per cell were detected intracellularly. Eosinophils from patients displayed significantly more unoccupied receptors than cells from normal donors. This number correlated to both serum IgE concentrations and to membrane-bound IgE. The lack of FcεRI expression by mouse eosinophils has hampered further studies. To overcome this fact and experimentally confirm our findings on human eosinophils, we engineered IL-5 × hFcεRIα double-transgenic mice, whose bone marrow, blood, spleen, and peritoneal eosinophils expressed FcεRI levels similar to levels of human eosinophils, after 4 days culture with IgE in the presence of IL-5. Both human and mouse eosinophils were able to secrete IL-10 upon FcεRI engagement. Thus, comparative analysis of cells from patients and from a relevant animal model allowed us to clearly demonstrate that FcεRI-mediated eosinophil activation leads to IL-10 secretion. Through FcεRI expression, these cells are able to contribute to both the regulation of the immune response and to its effector mechanisms.
Using Translation Paraphrases from Trilingual Corpora to Improve Phrase-Based Statistical Machine Translation: A Preliminary Report

Statistical methods have proven to be very effective when addressing linguistic problems, specially when dealing with machine translation. Nevertheless, statistical machine translation effectiveness is limited to situations where large amounts of training data are available. Therefore, the broader the coverage of a SMT system is, the better the chances to get a reasonable output are. In this paper we propose a method to improve quality of translations of a phrase-based machine translation system by extending phrase-tables with the use of translation paraphrases learned from a third language. Our experiments were done translating from Spanish to English pivoting through French.
Exploring the role of visual perceptual grouping on the audiovisual integration of motion

In the present study, we explored the role of visual perceptual grouping on audiovisual motion integration, using an adaptation of the crossmodal dynamic capture task developed by Soto-Faraco et al. The principles of perceptual grouping were used to vary the perceived direction (horizontal vs vertical) and extent of apparent motion within the visual modality. When the critical visual stimuli, giving rise to horizontal local motion, were embedded within a larger array of lights, giving rise to the perception of global motion vertically, the influence of visual motion information on the perception of auditory apparent motion (moving horizontally) was reduced significantly. These results highlight the need to consider intramodal perceptual grouping when investigating crossmodal perceptual grouping.
Growth Models for Lettuce Cultivars Growing in Spring

The objectives of this study were to adjust the Gompertz and logistic models to fit the fresh and dry matters of leaves and fresh and dry matters of shoots of four lettuce cultivars and indicate the model that best describes the growth in spring. Cultivars Ceres, Gloriosa, Grandes Lagos, and Rubinela were grown in protected environment and in soilless system, in the spring of 2016 and 2017. Seven days after transplantation, fresh and dry leaf matters and fresh and dry shoot matters were weighed every four days until beginning of flowering. The Gompertz and logistic models were adjusted as a function of accumulated thermal sum. The parameters of the Gompertz and logistic models and their confidence intervals were estimated, the assumptions of the models were verified, the goodness-of-fit measures and critical points were calculated, and the parametric and intrinsic nonlinearities quantified. The logistic and Gompertz growth models fitted well to fresh and dry leaf and shoot matters of cultivars Ceres, Gloriosa, Grandes Lagos, and Rubinela, under spring conditions. The logistic model is the most suitable to describe the growth of lettuce cultivars.
Effect of Dental Practice Characteristics on Racial Disparities in Patient-Specific Tooth Loss

Objective:The objective of this study was to test the hypothesis that dental practice characteristics are associated with tooth loss incidence with both tooth-specific and patient-specific characteristics already taken into account. Research Design:A population-based prospective cohort study was conducted. In-person interviews and clinical examinations were done at baseline, 24, and 48 months, with telephone interviews every 6 months. Practices that coincidentally served participants in the study completed practice characteristics questionnaires. To increase inferential power when testing practice-level effects, detailed tooth-specific and patient-specific data were simultaneously taken into account in tests for association between practice-level effects and tooth loss. Setting:Data were from the Florida Dental Care Study. The key health outcome was tooth loss, a leading measure of a population's oral health. Participants:Eight hundred seventy-three African-Americans and non-Hispanic whites who had at least 1 tooth. Results:Certain practice characteristics were associated with tooth loss, including the racial mix of the practice's patient population; persons who attended practices with higher percentages of African-Americans were more likely to receive a dental extraction regardless of the individual patient's race. Conclusions:This is the first longitudinal report of increased risk for tooth loss resulting from practice-level effects. Although a patient-level racial disparity remained evident, and even with detailed tooth-specific and patient-level characteristics taken into account, racial differences in characteristics of practices attended independently contributed to the patient-level racial disparity in health.
‘Here There Be Monsters’:The public's perception of paedophiles with particular reference to Belfast and Leicester

This research study sought to investigate the public perception of paedophiles. It was undertaken in Belfast (Northern Ireland) and Leicester (England) in an attempt to determine whether or not regional variations existed in relation to the public's perception of paedophiles. In doing this, the study sought to test four hypotheses; (1) That the press affects the public's perception of paedophiles; (2) that the public's perception of paedophiles is not congruent with legal and clinical definitions; (3) that the Sarah Payne case has helped to reinforce the public's perception of a predatory paedophile; and (4) that the public's perception is based on fear and irrationality. These hypotheses were tested via the distribution of a questionnaire to an opportunistic sample on the streets of Belfast and Leicester. Although the results did not support the hypotheses, they did yield some very interesting information. The study indicated that the public is quite well-informed about paedophilia; its recurrence rates, practices and in particular the influence of the media. Furthermore, the study indicated quite significant differences between the cities of Belfast and Leicester. In conclusion, the results indicated that a moral panic connected to paedophilia is very present in our contemporary society.
Electrophysiology of single heart cells from the rabbit tricuspid valve.

1. The electrophysiology of single myocytes isolated from the rabbit tricuspid valve was studied using the patch‐clamp method (whole‐cell configuration). Cell dispersion was achieved by collagenase treatment, using the Langendorff retrograde perfusion procedure. 2. After isolation, and while incubating in the recovery (Kraftbrühe) solution, cells had clear striations and were mostly spindle‐shaped, or rod‐like (less than 10%), with length varying from 35 microns to over 150 microns, and diameter from 3 to 10 microns. 3. Upon exposure to Tyrode solution, the calcium‐tolerant cells were mostly rounded with smooth surfaces and well‐defined borders. The mean diameter of these cells was 15 +/‐ 5 microns (S.D., n = 9). A smaller percentage (about 30%) retained the original elongated shape. 4. Patch pipette recordings showed the presence of spontaneous activity in about 30% of round cells, and less frequently in elongated cells. Maximum diastolic potentials (MDPs) in the round cells averaged ‐82 +/‐ 6 mV, with a take‐off potential of ‐56 +/‐ 3 mV (n = 9), and an average maximum upstroke velocity (Vmax) value of 6.3 +/‐ 0.6 V/s (n = 4). In quiescent cells, the mean resting potential was 69 +/‐ 12 mV (n = 43). 5. Voltage clamp ramps revealed a steady‐state I‐V relation with a negative slope region. The mean input resistance value was 25 +/‐ 9 M omega (n = 16) for the elongated, and 883 +/‐ 481 M omega (n = 8) for the round cells. 6. Hyperpolarizing 5 s pulses (holding potential = ‐50 mV) occasionally revealed a slow, time‐dependent inward current whose peak increased progressively as a function of clamp potential. The slowly activating current was sensitive to caesium 2 mM), indicating its similarity to the so‐called ‘pacemaker current’ (iF). In alternate voltage‐ and current‐clamp experiments, blocking of iF did not stop pacemaker activity, but there was up to a fourfold increase in pacemaker cycle length. 7. In some cells, 5 s hyperpolarizing steps from a holding potential of ‐40 or ‐50 mV produced large, inwardly directed and voltage‐dependent current surges that decayed rapidly with time, similar to the inactivation described for the inward rectifier current, iK1. The current was very prominent at voltages more negative than ‐100 mV, and its decay process was best fitted by two time constants, one fast and one slow. For example, at ‐150 mV the time constants were 61 and 634 ms. The inward current was blocked by barium (1 mM). (ABSTRACT TRUNCATED AT 400 WORDS)
Characterization of Helicobacter pylori factors that control transformation frequency and integration length during inter‐strain DNA recombination

Helicobacter pylori is a genetically diverse bacterial species, owing in part to its natural competence for DNA uptake that facilitates recombination between strains. Inter‐strain DNA recombination occurs during human infection and the H. pylori genome is in linkage equilibrium worldwide. Despite this high propensity for DNA exchange, little is known about the factors that limit the extent of recombination during natural transformation. Here, we identify restriction‐modification (R‐M) systems as a barrier to transformation with homeologous DNA and find that R‐M systems and several components of the recombination machinery control integration length. Type II R‐M systems, the nuclease nucT and resolvase ruvC reduced integration length whereas the helicase recG increased it. In addition, we characterized a new factor that promotes natural transformation in H. pylori, dprB. Although free recombination has been widely observed in H. pylori, our study suggests that this bacterium uses multiple systems to limit inter‐strain recombination.
Spondyloarthritis: a strong predictor of early coronary artery bypass grafting

Objectives: The main aim of the study was to examine whether patients with spondyloarthritides underwent their first coronary artery bypass grafting (CABG) at a younger age than those without spondyloarthritides. Methods: Patients who underwent their first CABG at the Feiring Heart Clinic during 2001–2005 were preoperatively screened for spondyloarthritides, and the cardiological assessment was registered. We compared the characteristics of patients with and without spondyloarthritides. Results: Of the 3852 patients undergoing their first CABG, 30 (0.78%) had spondyloarthritides. No statistically significant differences in traditional cardiovascular risk factors were found. The mean ages of patients with and without spondyloarthritides were 60.1 (SD = 8.7) and 66.9 (SD = 10.1) years, respectively. Spondyloarthritis was found by multivariate analysis to be a stronger independent predictor of early CABG than traditional cardiovascular risk factors [adjusted beta −6.2, p<0.001, 95% confidence interval (CI) −9.5 to −2.8]. Sixty per cent of spondyloarthritis patients and 52% of control patients had already suffered a myocardial infarction (p = 0.4). Conclusion: Spondyloarthritis was a stronger predictor of early CABG than most of the registered traditional cardiovascular risk factors. The prevalence of spondyloarthritis seemed to be higher in the CABG population than in the general population. These findings may indicate accelerated coronary artery disease (CAD) in spondyloarthritides.
Pyogenic infections occurring primarily in intervertebral discs.

1. Pyogenic infection of the intervertebral disc in fifteen patients is described. 2. The importance of certain radiological signs in establishing the diagnosis is discussed. 3. Delayed diagnosis is believed to be responsible for the high incidence of paraplegia in this condition. 4. The place of operation in the management of this lesion is considered.
Multicenter evaluation of the in vitro activities of three new quinolones, sparfloxacin, CI-960, and PD 131,628, compared with the activity of ciprofloxacin against 5,252 clinical bacterial isolates

The in vitro activities of three new quinolones (sparfloxacin, CI-960, and PD 131,628) were compared with that of ciprofloxacin against 5,252 routine clinical aerobic and facultatively anaerobic bacterial isolates. Overall, CI-960 was the most active drug in vitro (MIC for 90% of the strains tested, 0.13 micrograms/ml); ciprofloxacin and sparfloxacin were the least active (MIC for 90% of the strains tested, 1.0 micrograms/ml). All three new quinolones, but particularly CI-960 and PD 131,628, exhibited significantly greater activity than ciprofloxacin against enterococci and staphylococci.
GAINING UNDERSTANDING OF CAPITAL DISPARITY IN THE COMMUNITY COLLEGE CLASSROOM FROM A FACULTY PERSPECTIVE THROUGH ACTION RESEARCH

OF DISSERTATION GAINING UNDERSTANDING OF CAPTIAL DISPARITY IN THE COMMUNITY COLLEGE CLASSROOM FROM A FACULTY PERSPECTIVE THROUGH ACTION RESEARCH Positioned between the engagement rich secondary school and the highly social four-year institution, the community college has limited opportunities to connect with students. If community colleges are to meet challenges of providing access to education for students who have traditionally been underserved by higher education, and hold up to new measures of accountability in graduating students, two-year institutions must recognize that faculty-student engagements occurring in the classroom are crucial. Perception and appreciation of student’s capital by faculty through purposeful engagements grounded in theory provide opportunity for understanding capital disparity that exists in the community college classroom. Active participation of experienced faculty in an action research study was conducted and identified potential gaps of student-faculty interactions in the classroom, determined best-practice methods for increasing student-faculty interactions, incorporated identified best-practices in the classroom, and reflected upon their efficacy in improved student engagement. Sharing lessons learned by participants in an action research process with other practitioners, holds promise to increase our understanding of faculty funds of knowledge in the community college setting as well as processes that can be employed to help bring up capital and level out disparity.
Diversification of cropping systems under assured irrigated conditions in central plateau zone of Maharashtra

A field experiment was conducted for three consecutive years (2005-2007) at Parbhani to find out most produc- tive and profitable cropping system. Among the different cropping systems, highest wheat [( Triticum aestivum (L.) emend. Fiori & Paol] equivalent yield (19.9 t/ha) and net monetary returns (`107.8x103/ha) were obtained from soybean [ Glycine max (L. Merr.)]onion ( Allium capa L.) cropping system, followed by turmeric ( Curcuma domestica L.)+ castor ( Ricinus communis L.) (WEY-14.0 t/ha, and NMR `89.8x103/ha). The soybeanonion sys- tem also recorded maximum net monetary advantage per unit time (`573/ha/day), employment (374 mandays) and water use efficiency (221 kg/ha-cm), followed by turmeric+castor intercropping system. The highest nutrient uptake was recorded in sorghum [ Sorghum bicolor (L.) Moench]wheat followed by maize ( Zea mays L.) + cow- pea ( Vigna sinensis L.)wheat and maizewheat cropping systems. The highest soil nutrient status was observed in cotton ( Gossypium sp.)summer groundnut ( Arachis hypogaea L.) followed by soybeanonion cropping sys- tems.
Observable and Unobservable Aspects of Traits in Self—Other Comparisons

Previous research on absolute trait judgments regarding self and others showed that, compared to self-judgments, other-judgments involve greater focus on external, observable (as opposed to internal, unobservable) aspects of traits. The present research attempted to extend those findings to comparative judgments. In two experiments, Polish undergraduates (N = 144) were asked to perform a series of comparative self–other judgments followed by a series of absolute judgments regarding either the self or another person. The absolute judgments employed the same traits as the comparative judgments but with the trait preceded by a qualifier: either “feels,” referring to covert, unobservable aspects of the trait, or “looks,” referring to overt, observable aspects. As expected, comparative judgments correlated higher with absolute feels judgments regarding the self and with absolute looks judgments regarding the other than with absolute looks judgments regarding the self and absolute feels judgments regarding the other. This occurred for self–other judgments involving acquaintances but not for self–other judgments involving close friends.