Miracle-dz/UniFAR-FTUs huggingface dataset:
Intraoperative pathologic examination: cost effectiveness and clinical value in patients with cytologic diagnosis of cellular follicular thyroid lesion.

OBJECTIVE Routine use of intraoperative pathologic examination (IOPE), including frozen section (FS) and scrape preparation cytology (SPC), during diagnostic thyroid lobectomy continues to be a source of controversy. We sought to better delineate the usefulness and cost-benefit ratio of IOPE in the context of cytologically diagnosed cellular follicular lesion (CFL) or follicular neoplasm (FN). DESIGN Records of 205 patients who underwent thyroidectomy for cytologically diagnosed FN or CFL between 1997 and 2005 were retrospectively reviewed. IOPE results, patient demographics, and tumor characteristics were correlated to final histopathologic diagnoses. Sensitivity, specificity, predictive values, accuracy, and costs of IOPE were calculated. MAIN OUTCOME IOPE correctly identified 3 of 16 follicular carcinomas and 9 of 36 papillary carcinomas. Sensitivity, specificity, and accuracy were 23%, 99%, and 78%, respectively. On univariate analysis, malignancy risk among follicular nodules did not correlate with age, gender, or nodule size. On multivariate analysis, nodule size was predictive of malignancy (p < 0.05). Over the entire patient series, routine IOPE resulted in a net cost savings of $74,304.33. CONCLUSIONS IOPE reduced costs and limited the number of completion thyroidectomies necessary. IOPE is specific, cost effective, and of minimal additional risk when performed routinely for patients with CFL or FN.
CREB‐mediated Bcl‐2 expression contributes to RCAN1 protection from hydrogen peroxide‐induced neuronal death

Regulator of calcineurin 1 (RCAN1) is located on the Down syndrome critical region (DSCR) locus in human chromosome 21. In this study, we investigated the functional role of RCAN1 in the reactive oxygen species (ROS)‐mediated neuronal death signaling. We found that RCAN1 was able to protect the cells from H2O2‐induced cytotoxicity. The expression of RCAN1 caused an inhibition of the H2O2‐induced activation of mitogen‐activated protein kinases (MAPKs) and AP‐1. In contrast, RCAN1 significantly enhanced the activity of cAMP response element‐binding protein (CREB). Furthermore, RCAN1 induced the expression of the CREB target gene, Bcl‐2. Consistently, knockdown of endogenous RCAN1 using shRNA down regulated the phosphorylation of CREB and the expression of Bcl‐2, which protects the cells from H2O2‐induced cytotoxicity. Our data provide a new mechanism for the cytoprotective function of RCAN1 in response to oxidant‐induced apoptosis. J. Cell. Biochem. 114: 1115–1123, 2013. © 2012 Wiley Periodicals, Inc.
Theory of safe replacements for sequential circuits

We address the problem of developing suitable criteria for design replacement in the context of sequential logic synthesis. There have been previous efforts to characterize replacements for such designs. However, all previous attempts either make implicit or explicit assumptions about the design or the environment of the design. For example, it is widespread practice to assume the existence of a hardware reset line and, consequently, a fixed power-up state; in the absence of the same, a common premise is that the design's environment will apply an initializing sequence. We present the notion of safe replaceability, which does away with these assumptions, and prove a number of properties that hold of it. Most importantly, we show that the notion is sound, i.e., if design D/sub 1/ is a safe replacement for design D/sub 0/, then no environment can determine if D/sub 1/ is used in place of D/sub 0/ and that the notion is complete, i.e., if D/sub 1/ is not a safe replacement for D/sub 0/ then there exists an environment that can detect if D/sub 1/ is used in place of D/sub 0/. Completeness is important for logic synthesis and verification because it specifies the maximum allowable flexibility for replacement. When the design's output is not used for a certain number of cycles after power up, then safe replaceability can be relaxed to obtain what we refer to as delay safe replaceability; we analyze properties of this notion too. Since our work, many papers have used this notion effectively for sequential optimization.
Industrial policy and firm heterogeneity

Our concern is about a firm-specific industrial policy. When R&D subsidies or taxes are differentiated among firms, the question arises which firms in an industry should receive such support. We analyse a situation where firms differ in their R&D technologies in two distinct ways: they differ both in the costs of performing R&D activities and in the output obtained from such activities. The introduction of several domestic firms creates a corrective motive for government intervention with the firms' R&D activities in addition to Spencer and Brander's strategic motive. We find that the optimal firm-specific industrial policy is affected differently by the two sources of firm heterogeneity. Moreover, a change in a firm's R&D productivity has an ambiguous effect on the optimal policy towards the firm.
Manual lymphatic drainage in chronic venous disease: A duplex ultrasound study

Objectives To compare the effect of call-up and reabsorption maneuvers of manual lymphatic drainage on blood flow in femoral vein and great saphenous vein in patients with chronic venous disease and healthy controls. Methods Forty-one subjects participated in this study (mean age: 42.68(15.23)), 23 with chronic venous disease (chronic venous disease group) with clinical classification C1–5 of clinical-etiological-anatomical-pathological (CEAP) and 18 healthy subjects (control group). Call-up and reabsorption maneuvers were randomly applied in the medial aspect of the thigh. The cross-sectional areas, as well as the peak and the mean blood flow velocity at femoral vein and great saphenous vein, were assessed by Duplex ultrasound at the baseline and during maneuvers. The venous flow volume changes were calculated. Results The venous flow volume in femoral vein and great saphenous vein increased during both manual lymphatic drainage maneuvers and in both groups (P < 0.05). The two maneuvers had a similar effect on femoral vein and great saphenous vein hemodynamics, and in both the chronic venous disease and control groups. As a result of the call-up maneuver, the flow volume augmentations, as a result of call-up maneuver, decreased with the severity of chronic venous disease in those patients measured by the clinical classification of CEAP (r = −0.64; P = 0.03). Conclusions Manual lymphatic drainage increases the venous blood flow in the lower extremity with a magnitude that is independent from the specific maneuver employed or the presence of chronic venous disease. Therefore, manual lymphatic drainage may be an alternative strategy for the treatment and prevention of venous stasis complications in chronic venous disease.
Interest Rate Swaps and Corporate Financing Choices

This paper describes the firm's decision to borrow short- term versus long-term and shows how the introduction of interest rate swaps affects this choice. The model shows that in the absence of a swap market, interest rate uncertainty can lead firms to substitute long-term for short-term financing. However, when swaps exist, there is a tendency for firms that expect their credit quality to improve to borrow short-term and use swaps to hedge interest rate risk. The model suggests that, while the demand for fixed for floating swaps is enhanced, the demand for floating for fixed swaps is reduced by the presence of asymmetric information. Copyright 1992 by American Finance Association.
Participation in Rotating Savings and Credit Associations in Indonesia: New Empirical Evidence on Social Capital

Indonesia has a rich historical tradition of mutual cooperation at the community level. This study argues that rotating savings and credit associations (ROSCAs) constitute successful experiences of collective action within the informal financial sector. Therefore, using data from Indonesia Family Life Surveys, it explores the relationship between social capital and ROSCA participation and extends existing models from individual- to community-level determinants. The endowment of social capital at the village level correlates positively with individual ROSCA participation, because community social capital provides individual members with the resources needed to overcome self-selection and foster coordination -two main characteristics of ROSCAs. These results provide new evidence on the role of social capital for fostering collective action and offer new insights about community-driven development.
Financial policies in socialist countries in transition

One legacy of central planning, says the author, is that the financial systems in the transitional economies are even less developed than in many developing countries. He contends that the main goal of financial reform in these economies should be to make passive financial systems active - to make financial systems participate actively in the economy, as they do in market economies. For this to happen, the transitional economies must develop banking systems that allocate credit efficiently. Commercial banks must screen borrowers and monitor and discipline enterprises. The role of the government or the central bank should be limited to regulation and supervision. Most transitional economies have adopted a gradual approach to reforming their financial systems, maintaining the banking system's passive role. But banking reform in Eastern Europe cannot wait for enterprise restructuring and privatization, because both banks and state enterprises are burdened with inherited bad debts that endanger their solvency and hence that of the economy. The financial restructuring of banks and enterprises should be undertaken simultaneously, says the author, and should start early in the transition. Commercial banks should play an active role in the financial restructuring of enterprises. Governments must take responsibility (through the budget) for the debts of nonviable enterprises in a transparent manner and for the recapitalization of banks after their clean-up. Otherwise the healthy segments of the commercial sectors will have to carry the burden of financial restructuring, which will slow down the transition. Early in the transition, attention must also be paid to improving the system of payments, demonopolizing banking, changing the structure of ownership (including privatization), and introducing market-based financial legislation. The speed of financial reform will depend greatly on the availability of skilled banking professionals, on access to technical assistance from abroad, fiscal constraints, and of course on specific country circumstances. For example, for most countries of the former Soviet Union - except, for the Baltic states - a prerequisite to successful financial restructuring is macroeconomic stabilization and the reduction of high inflation rates. The most important lesson from countries further along in reform is that financial reform should not be delayed but should start as soon as possible. Delays reduce living standards (burdening the healthy parts of the economy with direct taxes or high financial costs), discourage small-scale entrepreneurs, inhibit the entry of new forms, and cause the economy to stagnate further.
Level of Fluoride in Soil, Grain and Water in Jalgaon District, Maharashtra, India.

INTRODUCTION Fluoride has an influence on both oral as well as systemic health. The major source of fluoride to body is through drinking water as well as through diet. Staple diet mainly depends on local environmental factors, food grains grown locally, its availability etc. Determination of fluoride level in these food grains is important. So, estimation of the amount of fluoride in grains and its relation to the sources of fluoride used for their cultivation viz., soil and water is important. AIM To estimate the relation of fluoride concentration in grains (Jowar) with respect to that of soil and water used for their cultivation. MATERIALS AND METHODS Fifteen samples each of soil, water and grains were collected using standardized method from the same farm fields of randomly selected villages of Jalgaon district. Fluoride ion concentration was determined in laboratory using SPADNS technique. Mean difference in fluoride levels in between the groups were analyzed using ANOVA and Post-Hoc Tukey test. Linear regression method was applied to analyse the association of the fluoride content of grain with water and soil. RESULTS There was a significant difference in between mean fluoride levels of soil and water (p<0.001) and in between soil and grain (p<0.001); however, difference in between mean fluoride levels of water and grain was found to be non significant (p=0.591). Also fluoride levels in all the three groups showed significant association with each other. CONCLUSION Fluoride level of soil, grains and water should be adjusted to an optimum level. Soil has positive correlation with respect to uptake of fluoride by Jowar grains. So, Jowar grains with optimum fluoride content should be made available in the commercial markets so that oral and general health can be benefitted.
Discourse Coalitions and the Australian Climate Change Policy Network

Ever since the agreement of the United Nations Framework Convention on Climate Change, climate change has become the most prominent global environmental issue on domestic political agendas. The author examines how a policy-network approach can contribute to the analysis of domestic climate change responses. Consideration is given to the role of advocacy coalitions and discourse coalitions within policy networks. It is argued that the discourse-coalition approach offers a useful explanation of the processes of coalition formation, interaction, and policy learning. Although it cannot alone explain the outcomes of the policy process, its emphasis on the dynamics of meaning, legitimacy, and knowledge as an essential part of policymaking can usefully be incorporated into an analysis of policy networks.
Molecular Genetic Parameters in Pathogenesis and Prognosis of Testicular Germ Cell Tumors

Aim of this review article was to critically analyze the recently described cytogenetic and molecular markers for testicular germ cell tumors with regard to their clinical utility. The isochromosme i(12p) represents the most common and characteristic cytogenetic finding which already appears in testicular carcinoma in situ. A number of proto–oncogenes (cyclin D and PTHLH) as well as putative tumor suppressor genes are localized on 12p; however, their role in pathogenesis and prognosis of testicular germ cell tumors has not been defined yet. Clinical characteristics of patients with familial testicular germ cell tumors indicate a genetic background for the development of testicular tumors. Although a number of chromosomal loci encoding potential testicular tumor susceptibility genes have been identified, the genetic basis of testicular cancer pathogenesis is still unknown. With regard to molecular prognostic risk factors most of the reported data on proliferation markers, tumor suppressor genes, proteases and adhesion molecules have to be confirmed in prospective randomized trials prior to their widespread clinical use. Based on the available data on prospective studies the percentage of embryonal carcinoma and vascular invasion appear to be the most significant prognosticators. Investigation and identification of those factors determining the aggressive biologic behavior of embryonal carcinoma compared to all other histological components appear to be most promising in the research for prgnosticators of metastatic disease. In conclusion, the increasing knowledge of molecular genetic events involved in pathogenesis and prognosis of testicular germ cell tumors will not only help to better understand development and progression of testicular cancer, but it will also define new approaches to classification and management of germ cell tumors
An Evaluation of Investment Banker Acquisition Advice: The Shareholders' Perspective

This paper studies the performance of Drexel Burnham Lambert, First Boston, Goldman Sachs, Morgan Stanley, Salomon Brothers, Shearson Lehman Brothers, and a set of "other" investment bankers in providing merger advice. By determining CARs of target firms, it investigates premiums paid by investment bank clients. To assess the benefit of the acquisition to the acquirer, CARs of acquiring firms are also assessed. The results indicate that Drexel clients pay smaller premiums to acquire their targets than clients of the other investment banks investigated. The results also indicate that the performance of First Boston clients in the period surrounding a merger announcement is dominated by all other investment banks in the sample.
Rapid kinetic and isotopic studies on dialkylglycine decarboxylase.

The two half-reactions of the pyridoxal 5'-phosphate (PLP)-dependent enzyme dialkylglycine decarboxylase (DGD) were studied individually by multiwavelength stopped-flow spectroscopy. Biphasic behavior was found for the reactions of DGD-PLP, consistent with two coexisting conformations observed in steady-state kinetics [Zhou, X. , and Toney, M. D. (1998) Biochemistry 37, 5761--5769]. The half-reaction kinetic parameters depend on alkali metal ion size in a manner similar to that observed for steady-state kinetic parameters. The fast phase maximal rate constant for the 2-aminoisobutyrate (AIB) decarboxylation half-reaction with the potassium form of DGD-PLP is 25 s(-1), while that for the transamination half-reaction between DGD-PMP and pyruvate is 75 s(-1). The maximal rate constant for the transamination half-reaction of the potassium form of DGD-PLP with L-alanine is 24 s(-1). The spectral data indicate that external aldimine formation with either AIB or L-alanine and DGD-PLP is a rapid equilibrium process, as is ketimine formation from DGD-PMP and pyruvate. Absorption ascribable to the quinonoid intermediate is not observed in the AIB decarboxylation half-reaction, but is observed in the dead-time of the stopped-flow in the L-alanine transamination half-reaction. The [1-(13)C]AIB kinetic isotope effect (KIE) on k(cat) for the steady-state reaction is 1.043 +/- 0.003, while a value of 1.042 +/- 0.009 was measured for the AIB half-reaction. The secondary KIE measured for the AIB decarboxylation half-reaction with [C4'-(2)H]PLP is 0.92 +/- 0.02. The primary [2-(2)H]-L-alanine KIE on the transamination half-reaction is unity. Small but significant solvent KIEs are observed on k(cat) and k(cat)/K(M) for both substrates, and the proton inventories are linear in each case. NMR measurements of C2--H washout vs product formation give ratios of 105 and 14 with L-alanine and isopropylamine as substrates, respectively. These results support a rate-limiting, concerted C alpha-decarboxylation/C4'-protonation mechanism for the AIB decarboxylation reaction, and rapid equilibrium quinonoid formation followed by rate-limiting protonation to the ketimine intermediate for the L-alanine transamination half-reaction. Energy profiles for the two half-reactions are constructed.
Niche restriction in parasites: proximate and ultimate causes

SUMMARY Hutchinson's (1957) definition of an ecological niche as a multidimensional hypervolume determined by a number of physical and biotic variables is adopted. The number of niche dimensions is very great, but as a working hypothesis it is assumed that a few are sufficient to characterize the niche of a parasite species to a high degree of accuracy. They are host species, microhabitat(s), macrohabitat(s), geographical range, sex and age of host, season, food and hyperparasites. Methods to measure niche width, in particular specificity indices, are discussed, and some examples of niche restriction are described. Proximate and ultimate causes of niche restriction are discussed, mainly using marine parasites as examples. Among proximate causes of one niche dimension, host specificity, are ecological factors restricting exposure to infection to certain host species; host-specific chemical factors that induce hatching, direct infective stages to a host and bring about settlement of a parasite; factors that lead to mortality in or on the wrong host; morphological adaptations that guarantee survival in or on the ‘correct’ host; and availability of suitable hosts. Many factors are likely to be responsible for microhabitat specificity, but have been little studied, except for some physiological and morphological adaptations to particular microhabitats. Macrohabitats and geographical range may be determined by the distribution of intermediate hosts and certain food items, and by a variety of chemical and physical factors. Hosts of different sexes may differ in feeding habits and the composition of the skin, and thus acquire parasites differentially. Hosts of different age may be differentially infected due to accumulation of parasites with age, loss of parasites due to developing resistance (or immunity), and different size and feeding habits. Among ultimate causes of niche restriction and segregation are avoidance of competition, predation and hyperparasites; facilitation of mating; reinforcement of reproductive barriers; and adaptations to environmental complexity. Few studies permit a decision on which factor or factors are responsible in particular cases. Interspecific competition may play a greater role in helminth communities of some host groups than of others, but it seems that, overall, its role has been exaggerated at least for marine parasites. Some ‘classical’ examples of microhabitat segregation explained by interspecific competition can also be explained by reinforcement of reproductive barriers. There is evidence for the importance of facilitation of mating in microhabitat restriction, and the availability of many vacant niches indicates that competition, overall, is not of great importance.
Effects of basic combat training on iron status in male and female soldiers: a comparative study.

OBJECTIVE Iron is an essential micronutrient known to affect physical and cognitive performance. Studies indicate a significant reduction in iron status in female Soldiers immediately following military training, although the comparative effects of military training on iron status between male and female Soldiers have not been examined. The objective of this study was to compare the longitudinal effects of US Army basic combat training (BCT) on iron status indicators in a group of male and female Soldiers. METHODS A total of 154 male and female Soldiers (89 and 65, respectively) completed the study. Blood was collected at 4 time-points during BCT (weeks 0, 3, 6, 9) and dietary iron intake was assessed at weeks 0 and 9. Iron status indicators included hemoglobin, serum ferritin (SF), soluble transferrin receptor (sTfR), and transferrin saturation (TS). RESULTS Iron status was greater in male Soldiers than female Soldiers, as hemoglobin and SF levels were higher (P<.05) and sTfR levels were lower (P<.05) in males as compared to females at each time-point. Despite a mean increase of greater than 25% in iron intake (mg/day) among both male (15±13 to 20.2±14.4) and female Soldiers (12.8±9.7 to 16±6.2) over the course of BCT, iron status declined in both groups. As compared to baseline, SF declined (P<.05) by 21% and 47%, sTfR increased (P<.05) by 17% and 30%, and TS declined (P<.05) by 23% and 54% in male and female Soldiers, respectively, over the course of BCT. CONCLUSIONS These data indicate that although dietary iron intake improves, iron status declines in both male and female Soldiers during BCT, and the decline in female Soldiers is of a greater magnitude. Future studies should aim to determine the mechanism by which iron status declines during military training, with a focus on functional outcomes affecting Soldier health and performance.