Miracle-dz/UniFAR-FTUs huggingface dataset:
Resistance Pattern of Nitrofurantoin of Uropathogens in Different Age Groups at Dr. Lal Path Labs, National Reference Laboratory, Rohini, Delhi

Aims and Objectives: This study was undertaken to highlight the resistance pattern of Nitrofurantoin among 5162 UTIs causing isolates at Microbiology Department of Dr. Lal Path Labs between April to June 2019. Materials and Methods: This retrospective study was performed in Department of Microbiology at Dr. Lal Path Labs, Delhi during period April to June 2019. Standard loopful midstream urine samples collected in a sterile container were inoculated on UTI Chromagar and incubated overnight at 37ºC and demonstrating significance colony count of ≥105 CFU/ml. Common Enterobacteriaceae group of isolates and Gram positive isolates identified by MALDI TOF-MS (Bruker, Daltonics) were included in this study. To determine Nitrofurantoin resistance by VITEK-AST (Biomerieux) system on 280/P628 antibiotic susceptibility testing cards respectively as per as CLSI M100-S-29. Proteus spp, Pseudomonas spp. , Acinetobacter spp, of complicated UTI isolates were excluded from this study. Results: Of the 29485 urine samples tested during April to June 2019, 5162 (17.5%) were culture positive. Out of the 5162 positive isolates 2856 (55.3%) were isolated from female patients and 2306 (44.7%) from male patients. The most common bacterial isolates were members of Enterobacteriaceae 4728 (91.5%) and Gram positive were 434 (8.5%). The most predominant age group infected with uropathogens were elderly adults ≥ 50 years of age constituted 58.1% of the UTIs culture positive cases. Klebsiella pneumoniae demonstrated highest resistance of 92.3% whereas Staphylococcus aureus demonstrated the least resistance of 8.3%. Discussion and Conclusion: The alarming substantial resistance to Nitrofurantoin in decreasing order has been noticed in Enterobacteriaceae i.e., Klebsiella pneumonia (92.3%), Enterobacter spp. (58.2%), Citrobacter spp (42.6%) and Gram positive Enterococcus spp. (45.6%) which is across all age groups. Most susceptible to Nitrofurantoin were Escherichia coli (69.9%) in Gram negative and Staphylococcus aureus (91.7%) in Gram positive. This finding emphasis the need of robust restriction of Nitrofurantoin antibiotic policy and usage to uncomplicated UTIs caused by Escherichia coli and Staphylococcus aureus.
The Running and Technical Performance of U13 to U18 Elite Japanese Soccer Players During Match Play.

Goto, H and Saward, C. The running and technical performance of U13 to U18 elite Japanese soccer players during match play. J Strength Cond Res XX(X): 000-000, 2019-The aims of the current study were (a) to examine age-related differences in match running performance with 2 different approaches (speed vs. metabolic power) in U13-U18 Japanese elite soccer players and (b) to examine age-related differences in technical match performance in U13-U18 Japanese elite soccer players. Participants were 110 outfield players from academies of 2 professional soccer clubs in Japan. Forty-eight 11-a-side official league matches (13, 6, 9, 7, 6, and 7 matches for U13, U14, U15, U16, U17, and U18 age-groups, respectively) were analyzed (152 complete match files). Global positioning system (15 Hz) and video analysis were used to analyze running and technical performance during matches, respectively. Total distance covered in absolute terms (U13 < [U14 and U15] < [U16-U18]; p < 0.05 for all), high-intensity running distance ([U13-U15] < [U16-U18]; p < 0.05 for all), and distance covered during the metabolic power zone of ≥35 W·kg relative to match playing time ([U13 < U16], [U13-U15] < [U17 and U18]; p < 0.05 for all) increased with age. The speed zone based approach (high-intensity running distance, ≥4.0 m·s) underestimated high-intensity demands compared with the metabolic power zone based approach (≥20 W·kg) by ∼33 to ∼57% (p < 0.01 for all), with the underestimation declining with age (p < 0.001). Pass accuracy improved with age from 73% at U13 to 85% at U18 (p < 0.001). Therefore, distance covered at high speeds and at high metabolic powers, and pass accuracy increase with age. Moreover, the speed zone based approach underestimates the demands of match play in Japanese elite youth soccer players. The current results could support coaches to develop players, identify talent, and produce age-specific training programs.
The Role of Causal Attribution and Implicit Mindset in Development of Wisdom

Many wisdom studies explore the essential characteristics required to be considered wise. These studies fail to consider how one can develop these characteristics; in particular, they fail to explain the personal and cultural characteristics that influence motivation to become wise. In this study, we looked at 160 participants’ causal beliefs about wisdom in two different cultures, Iran and Canada, and created a coding scheme to categorize what ordinary people believe causes wisdom. A mixed method analysis pointed out that attribution styles affect implicit mindset towards developing wisdom in both cultures: people who have controllable attributions (associated with incremental theory) are more likely be optimistic about developing wisdom, while individuals with uncontrollable causal attributions (associated with entity theory) are more likely to be pessimistic about developing wisdom. Our results support previous findings on the importance of mindset and causal beliefs in achievements and add to the wisdom literature by empirically investigating the role of motivational disposition on wisdom scores.
“Nonsignificant” early repolarization pattern on postresuscitation ECG as a harbinger of impending electrical storm

We report a 55‐year‐old man who was resuscitated from out‐of‐hospital cardiac arrest and subsequently developed three episodes of ventricular fibrillation (VF) on the same day. Early repolarization (ER) pattern was not significant (<0.1 mV) on postresuscitation ECG. However, ER pattern became evident (0.25 mV) before the onset of VF and then completely disappeared. The unusual dynamics of ER pattern observed in the present case could be called “masked” ER syndrome.
Integrating finite element modelling and 3D printing to engineer biomimetic polymeric scaffolds for tissue engineering

ABSTRACT The suitability of a scaffold for tissue engineering is determined by a number of interrelated factors. The biomaterial should be biocompatible and cell instructive, with a porosity and pore interconnectivity that facilitates cellular migration and the transport of nutrients and waste products into and out of the scaffolds. For the engineering of load bearing tissues, the scaffold may also be required to possess specific mechanical properties and/or ensure the transfer of mechanical stimuli to cells to direct their differentiation. Achieving these design goals is challenging, but could potentially be realised by integrating computational tools such as finite element (FE) modelling with three-dimensional (3D) printing techniques to assess how scaffold architecture and material properties influence the performance of the implant. In this study we first use Fused Deposition Modelling (FDM) to modulate the architecture of polycaprolactone (PCL) scaffolds, exploring the influence of varying fibre diameter, spacing and laydown pattern on the structural and mechanical properties of such scaffolds. We next demonstrate that a simple FE modelling strategy, which captures key aspects of the printed scaffold’s actual geometry and material behaviour, can be used to accurately model the mechanical characteristics of such scaffolds. We then show the utility of this strategy by using FE modelling to help design 3D printed scaffolds with mechanical properties mimicking that of articular cartilage. In conclusion, this study demonstrates that a relatively simple FE modelling approach can be used to inform the design of 3D printed scaffolds to ensure their bulk mechanical properties mimic specific target tissues.
Inclusive Education: Perceptions of Parents of Children with Special Needs of the Individual Program Planning Process

In inclusive education, students with special needs may access the curriculum through adapted or individualistic plans. Parental involvement in developing the individualistic plans is pertinent to the success of both their children’s education and the plan itself. Research from the United States offers insight into how parents perceive the process of developing individualist plans; however, limited research has been conducted with parents of children with special needs in Canada. This current study examines parental perceptions concerning the Individual Program Planning (IPP) process in Nova Scotia, Canada. Eight parents were interviewed using a guided interview format that consisted of 16 questions based on prior research on the subject matter. Qualitative analysis of the eight interviews resulted in the emergence of four key themes: a) Educator-Parent Communication, b) Parental Perception of Educational Climate, c) Parent Knowledge, and d) Improvements to the IPP process. Each category is reviewed here and supported with samples of direct quotations from parent interviewees. Recommendations are then suggested for educators and parents of children with special needs to promote positive and productive Individual Program Planning meetings.
Addictive behaviors in alcohol use disorder: dysregulation of reward processing systems and maladaptive coping strategies

Abstract DSM-5 has included within the substance-related and addictive disorders diagnostic category behavioral addictions, such as gambling disorder. Some scholars also considered ICD-11 compulsive sex as a behavioral addiction. Furthermore, an addiction model of dysfunctional eating behaviors has been proposed. Consistently, the existence of common addiction mechanisms related to substance and non-substance related disorders has been hypothesized. Nevertheless, this approach was called into question, especially considering alternative processes which might be implicated in such conditions. This study aims to compare these opposite theoretical positions concerning substance- and nonsubstance related disorders, investigating the latent structure of addictive behaviors among alcohol use disorder (AUD) individuals. Addictive behaviors were self-reported assessed using the Shorter PROMIS Questionnaire (SPQ). We recruited 456 (59.2% male; 40.8% female) AUD treatment-seeking patients. Two latent structures were tested using a confirmatory factor analytic approach. We compared a one-factor (i.e., common addiction mechanisms) with a two-factor solution (i.e., dysregulation of reward processing systems and maladaptive coping strategies). The two-factor solution showed adequate goodness-of-fit indexes. Specifically, dysregulation of the reward processing systems dimension predicted the SPQ illicit and prescription drugs, gambling, and sex subscales. Conversely, the maladaptive coping strategies dimension predicted the SPQ compulsive buying, binge eating and food restriction subscales. The latent dimensions significantly correlated with each other. Compulsive sex might be preliminarily considered as a behavioral addiction. AUD individuals might show complex patterns of maladaptive behaviors functionally related to different latent processes. Differential treatment approaches are suggested to treat these conditions.
Using the CONSORT statement to evaluate the completeness of reporting of addiction randomised trials: a cross-sectional review

Objectives Evaluate the completeness of reporting of addiction randomised controlled trials (RCTs) using the Consolidated Standards of Reporting Trials (CONSORT) statement. Setting Not applicable. Participants RCTs identified using a PubMed search of 15 addiction journals and a 5-year cross-section. Outcome measures Completeness of reporting. Results Our analysis of 394 addiction RCTs found that the mean number of CONSORT items reported was 19.2 (SD 5.2), out of a possible 31. Twelve items were reported in <50% of RCTs; similarly, 12 items were reported in >75% of RCTs. Journal endorsement of CONSORT was found to improve the number of CONSORT items reported. Conclusions Poor reporting quality may prohibit readers from critically appraising the methodological quality of addiction trials. We recommend journal endorsement of CONSORT since our study and those previous have shown that CONSORT endorsement improves the quality of reporting.
Induction and flow cytometry identification of mixoploidy through colchicine treatment of Trigonella foenum-graecum L.

Polyploidy plays an important role in plant evolution and constitutes an important mechanism of diversification and genetic variations creation. The objective of this study was to produce a polyploid cultivar of Trigonella foenum-graecum L . (2n=16) and to evaluate its cytological potentialities. Polyploidy induction was carried out by using a 0.05% colchicine solution. Ploidy level was determined by an analysis of flow cytometry, which is suitable, quick and easy for the identification of ploidy level. Quantification of DNA by spectrophotometric methods showed that treated plants presented higher contents of cellular DNA than diploid plants, and this quantification was checked by fluorescence method and comparison of the DNA profiles showed a more significant thickness of the DNA band in the extract from the treated plants than the diploid plants. In addition, the tested plants were classed as diploid and mixoploid by flow cytometry. The cytological characteristics such as the stomata size and pollen grain diameter of the mixoploid were significantly larger than those of the diploid. Polyploidy induction is an effective method to increase plant performance. Key words : Fenugreek, colchicine, flow cytometry, polyploidy, mixoploidy.
1 EARLY POSTNATAL GENISTEIN ADMINISTRATION PERMANENTLY AFFECTS NITRERGIC AND VASOPRESSINERGIC SYSTEMS IN A SEX-SPECIFIC

Early postnatal genistein administration permanently affects nitrergic and vasopressinergic systems in a sex-specific way / Ponti G; Rodriguez-Gomez A; Farinetti A; Marraudino M; Filice F; Foglio B; Sciacca G; Panzica GC; Gotti S. In: NEUROSCIENCE. ISSN 0306-4522. 346(2017), pp. 203-215. Original Citation: Early postnatal genistein administration permanently affects nitrergic and vasopressinergic systems in a sexspecific way
Effect of Temporary Shade Tree Species on Growth Performance of Newly Transplanted Arabica Coffee Seedlings at Jimma

A field experiment was conducted at Jimma Agricultural Research Centre (JARC) with an objective to investigate the effect of various temporary shade tree species on survival rate, early growth performance and field establishment of Arabica coffee seedlings between 2008 and 2014 cropping season. A randomized complete block design (RCBD) with three replications was used. The treatment consisted of temporary shade tree species vis . Pigeon pea ( Cajanus Cajan (L.) Millsp ) Tephrosia sp. Caster bean, Leucaena sp. , Sesbania sesbane , grass hat (‘’Gojo’’) and open plot as a control. Coffee seedlings were raised using a CBD resistant coffee cultivar, 74110 following the recommended nursery management practices. Each experimental plot constituted of 12 coffee seedlings planted at 2m by 2m spacing. Seeds of pigeon pea, Tephrosia , Caster bean, Luecnea and Sesbania sesbane which were collected and prepared have been sown between coffee rows in east and west directions so as to protect seedlings from morning and afternoon sun injury. Significant (P ≤ 0.05) variations were detected among treatments for nearly all growth parameters studied. Accordingly, almost all distractive and non-distractive growth parameters were considerably affected by temporary shade treatment. In general grass hat treatment followed by Sesbania sesban showed best growth performance of coffee seedlings. Thus areas with ample rainfall or soil moisture Sesbania sesban and Pigeon pea can be used as temporary shade for coffee seedlings if planted under wider spacing (4 m x 4 m) sesbania sesban and (2 m x 2 m) pigeon pea so as to reduce their competition effect with young coffee tree for climatic and soil resources. Keywords: - inter row, intra row, temporary shade tree and transplanted seedlings
The effect of vulvovaginal atrophy on women’s quality of life from an Italian cohort of the EVES study

Abstract Vulvovaginal atrophy (VVA) has an impact on the quality of life (QoL) of women. This post hoc analysis of the EVES study provides an overview of the QoL in postmenopausal Italian women in relation with VVA severity. We included 1066 women attending menopause/gynaecologic centres. A face-to-face survey (including QoL and sexual life questionnaires), joining an objective gynaecological examination to confirm VVA, were performed. The 65.5% of the participants presented severe vaginal, vulvar and/or urinary symptoms; an 86.9% had an objective confirmed VVA. Women with severe symptoms presented with significantly worse QoL scores than the women without. We found there were moderately significant correlations between vaginal and vulvar symptoms' severity and lower overall DIVA QoL scores (p<.0005, in both cases). Women with a confirmed VVA presented worse QoL scores than women without confirmation. Our data suggest a clear relationship between VVA severity and a decrease in QoL in postmenopausal Italian women. IMPACT STATEMENT What is already known on this subject? Vulvovaginal atrophy (VVA) appears as a common chronic disorder in postmenopausal women that, as soon as the oestrogen levels decrease, becomes a severe condition affecting their quality of life (QoL). What do the results of this study add? We provide new insight about QoL related to VVA severity in Italian postmenopausal women. Our local data demonstrates that QoL in Italian women suffering from menopause is directly related to the severity of vaginal and vulvar symptoms. The same correlation exists for urinary symptoms. QoL is also reduced in patients with an objectively confirmed VVA diagnosis. What are the implications of these findings for clinical practice and/or further research? The implications of our findings involve the need for a better management, not only of the physical aspects of VVA, but also of the non-physical dimensions. Clinicians should ask for the impact of VVA on QoL aspects, making postmenopausal women aware about the possible affected spheres. Medical personnel should conduct future campaigns in the Italian general population, not only in those asking for medical help, to make all women conscious about this silent disorder affecting physical and non-physical dimensions and in order to treat it at early stages.
Savings Mobilization, Financial Development and Liberalization: The Case of Malaysia

This paper attempts to identify the key factors behind Malaysia's remarkable savings performance. Drawing on the life cycle theory, the saving function is estimated by incorporating other relevant structural features and institutional settings of the Malaysian economy into the specification. Particular emphasis has been placed on the roles of financial factors in mobilizing funds in the private sector. The results suggest that financial deepening and increased banking density tend to encourage private savings. Development of insurance markets and liberalization of the financial system, however, tend to exert a dampening effect on private savings.
Analytical Formula for the Ratio of Central to Minimum Film Thickness in a Circular EHL Contact

Prediction of minimum film thickness is often used in practice for calculation of film parameter to design machine operation in full film regime. It was reported several times that majority of prediction formulas cannot match experimental data in terms of minimum film thickness. These standard prediction formulas give almost constant ratio between central and minimum film thickness while numerical calculations show ratio which spans from 1 to more than 3 depending on M and L parameters. In this paper, an analytical formula of this ratio is presented for lubricants with various pressure–viscosity coefficients. The analytical formula is compared with optical interferometry measurements and differences are discussed. It allows better prediction, compared to standard formulas, of minimum film thickness for wide range of M and L parameters.
Blood lead level: an overlooked risk of carpal tunnel syndrome in hemodialysis patients

Abstract Introduction: Carpal tunnel syndrome (CTS) is a severe complication observed in long-term maintenance hemodialysis (MHD) patients. The most common cause of CTS is dialysis-related β2-microglobulin amyloidosis, which is associated with inflammation and oxidative stress in dialysis patients. Patients on MHD have higher blood lead levels (BLLs) than the general population. Lead (Pb) exposure in chronic dialysis patients has been noted to induce oxidative stress and inflammation. Therefore, lead-related inflammation and oxidative stress might contribute to CTS. Methods: The medical records of 866 MHD patients were reviewed. Two hundred and thirty-four patients with symptoms of CTS were surveyed by senior neurologists via physical examinations and nerve conduction studies. Patients in this study were stratified into groups with low-normal (<10 μg/dL), high-normal (10 to 20 μg/dL), and abnormal (>20 μg/dL) BLLs. The associations between CTS and BLLs and the clinical data were analyzed. Results: Multivariate logistic regression analyses showed that Log BLL (OR: 54.810, 95% CI: 13.622–220.54, p < .001), high-normal BLLs (OR: 4.839, 95% CI: 2.262–10.351, p < .001) with low-normal BLL as a reference, high BLLs (OR: 12.952, 95% CI: 5.391–31.119, p < .001) with low-normal BLL as a reference, and a BLL >12.3 μg/dL (OR: 6.827, 95% CI: 3.737–12.472, p < .001) were positively associated with CTS according to three different analyses. Discussion: In conclusion, blood lead levels were positively associated with CTS in patients on MHD. Dialysis patients should pay more attention to their environmental exposure to Pb. Avoidance of environmental Pb may reduce the incidence of CTS in MHD patients. Future studies will address the role of Pb in the pathophysiology of CTS in this patient population.
High prevalence of equine‐like G3P[8] rotavirus in children and adults with acute gastroenteritis in Thailand

Group A rotavirus (RVA) is a major cause of acute gastroenteritis in infants and young children worldwide. This study aims to clarify the distribution of G/P types and genetic characteristics of RVAs circulating in Thailand. Between January 2014 and September 2016, 1867 stool specimens were collected from children and adults with acute gastroenteritis in six provinces in Thailand. RVAs were detected in 514/1867 (27.5%) stool specimens. G1P[8] (44.7%) was the most predominant genotype, followed by G3P[8] (33.7%), G2P[4] (11.5%), G8P[8] (7.0%), and G9P[8] (1.3%). Unusual G3P[9] (0.8%), G3P[10] (0.4%), G4P[6] (0.4%), and G10P[14] (0.2%) were also detected at low frequencies. The predominant genotype, G1P[8] (64.4%), in 2014 decreased to 6.1% in 2016. In contrast, the frequency of G3P[8] markedly increased from 5.5% in 2014 to 65.3% in 2015 and 89.8% in 2016. On polyacrylamide gel electrophoresis, most (135/140; 96.4%) of the G3P[8] strains exhibited a short RNA profile. Successful determination of the nucleotide sequences of the VP7 genes of 98 G3P[8] strains with a short RNA profile showed that they are all equine‐like G3P[8] strains. On phylogenetic analysis of genome segments of two representative Thai equine‐like G3P[8] strains, it was noteworthy that they possessed distinct NSP4 genes, one bovine‐like and the other human‐like. Thus, we found that characteristic equine‐like G3P[8] strains with a short RNA electropherotype are becoming highly prevalent in children and adults in Thailand.