Miracle-dz/UniFAR-FTUs huggingface dataset:
Tumor Boost Using External Beam Radiation in Cervical Cancer Patients Unable to Receive Intracavitary Brachytherapy: Outcome From a Multicenter Retrospective Study (Korean Radiation Oncology Group 1419)

Purpose We conducted this study to evaluate the outcomes of external-beam radiotherapy tumor boost (EBRT-B) in cervical cancer patients who could not receive intracavitary brachytherapy. Methods A total of 11 hospitals provided the data of patients who received EBRT-B during the period from January 2005 through October 2012. Results A total of 75 patients were included. The median radiotherapy dose was 46 Gy (range, 40–54 Gy) for whole pelvis and 24 Gy (range, 9–35 Gy) for EBRT-B. Initial tumor responses assessed at 2 to 6 months after radiotherapy were as follows: 46 with complete response, 22 with partial response, 2 with stable disease, and 3 with progressive disease. After a median follow-up time of 33 months, 30 patients (40.0%) showed disease progression including 21 (28.0%) with local progression. The 5-year local failure-free survival rate was 70.0%. Achieving complete response at the first follow-up visit and an overall treatment time of 53 days or less were significantly related to favorable local failure-free survival. The rate of grade 3 or higher toxicity was 2.6%. Conclusions Approximately 70% of patients had local tumor control after curative radiotherapy using EBRT-B. Early tumor response and overall treatment time of 53 days or less were closely associated with favorable local control.
A novel method for isolation of epithelial cells from ovine esophagus for tissue engineering.

PURPOSE The yield of a critical number of basal epithelial cells with high mitotic rates from native tissue is a challenge in the field of tissue engineering. There are many protocols that use enzymatic methods for isolation of epithelial cells with unsatisfactory results for tissue engineering. This study aimed to develop a protocol for isolating a sufficient number of epithelial cells with a high Proliferating Index from ovine esophagus for tissue engineering applications. METHODS Esophageal mucosa was pretreated with dispase-collagenase solution and plated on collagen-coated culture dishes. Distinction of the various types of epithelial cells and developmental stages was done with specific primary antibodies to Cytokeratins and to Proliferating Cell Nuclear Antigen (PCNA). RESULTS Up to approximately 8100 epithelial cells/mm2 of mucosa tissue were found after one week of migration. Cytokeratin 14 (CK 14) was positive identified in cells even after 83 days. At the same time the Proliferating Index was 71%. CONCLUSION Our protocol for isolation of basal epithelial cells was successful to yield sufficient numbers of cells predominantly with proliferative character and without noteworthy negative enzymatic affection. The results at this study offer the possibility of generation critical cell numbers for tissue engineering applications.
Family Involvement in School-Based Health Promotion: Bringing Nutrition Information Home

Abstract. Family-school collaboration related to children's physical development has become increasingly important as childhood obesity rates continue to rise. The present study described the development and implementation of a literacy-based, family component of a school-based health education program and investigated its viability, acceptability, and effectiveness. Interactive children's books were the mechanism by which students, parents, and teachers received consistent messages at home and school regarding nutrition information. The home–school intervention served to bridge home and school cultures in an urban population. Preliminary process evaluation results indicated that the interactive children's books were feasible to implement in the school context. Parents, children, and teachers had positive perceptions of the books. Parents who received the books demonstrated increased knowledge of “5 a Day,” which highlights the importance of eating fruits and vegetables. Although not statistically significant, after the first and second years of intervention, parents in the experimental group reported that their children were eating 0.54 and 0.36 additional servings of fruit and vegetables per day compared with children in the control group. The program did not seem to influence the availability and accessibility of fruits and vegetables at home.
Highly efficient and compact Sepic-Boost-Flyback integrated converter with multiple outputs

This paper proposes a topology of single input multiple-output DC-DC converter by integrating Sepic, Flyback and Boost configuration, whose individual outputs when series connected, results in very high DC-DC conversion ratio. The salient features of the proposed topology are less number of components resulting in a compact structure, less voltage stress of the power electronic devices, high efficiency of voltage step-up conversion, no additional circuitry requirement for the transformer leakage energy management. Explanation of the working of the circuit during its various operating modes are given. Derivation of the dynamic equations governing the various operating modes is done. A detailed analysis of the circuit is done in the steady state to obtain the expressions of its gain and the operating efficiency, considering the effect of the circuit parasitic elements. Plots of gain vs. duty cycle and efficiency vs. duty cycle are given at different power levels. To validate the proper working of the proposed topology, simulations have been done using Matlab-Simulink and results are included.
A hypocaloric diet enriched in legumes specifically mitigates lipid peroxidation in obese subjects

Legume intake could specifically protect against lipid peroxidation in addition to the effects associated to weight loss when included in hypocaloric diets. Thus, 30 obese subjects (age: 36 ± 8 years and BMI: 32.0 ± 5.3 kg/m2) were nutritionally treated by a 8-week energy restriction ( − 30% energy expenditure) with a legume enriched diet (4 days/week servings, ) or without legumes (control diet (CD), ). Body weight, circulating cholesterol, oxidized LDL (ox-LDL), malondialdehyde (MDA) and urinary 8-isoprostane F2α (8-iso-PGF2α) were measured at baseline and at endpoint. After the nutritional intervention, all obese subjects lost weight, specially those individuals who followed the legumes-enriched diet as compared to the CD ( − 7.7 ± 3 vs. − 5.3 ± 2.7%; p = 0.023), which was accompanied by marked decreases in total cholesterol levels (p < 0.001) and statistically significant diet-related reductions on plasma ox-LDL, plasma MDA and urinary 8-iso-PGF2α output. Therefore, a balanced diet with moderate caloric restriction including 4 day/week legume servings empowered the oxidative stress improvement related to weight loss through a reduction in lipid peroxidation as compared to a control hypocaloric diet.
Athlete characteristics and outcome scores for computerized neuropsychological assessment: a preliminary analysis.

CONTEXT Computerized neuropsychological testing is used in athletics; however, normative data on an athletic population are lacking. OBJECTIVE To investigate factors, such as sex, SAT score, alertness, and sport, and their effects on baseline neuropsychological test scores. A secondary purpose was to begin establishing preliminary reference data for nonsymptomatic collegiate athletes. DESIGN Observational study. SETTING Research laboratory. PATIENTS OR OTHER PARTICIPANTS The study population comprised 327 National Collegiate Athletic Association Division I athletes from 12 men's and women's sports. MAIN OUTCOME MEASURE(S) Athletes were baseline tested before their first competitive season. Athletes completed demographics forms and self-reported history of concussion (1 or no concussion and 2 or more concussions) and SAT scores (<1000, 1000 to 1200, and >1200). The 108 women had a mean age of 18.39 +/- 0.09 years, height of 167.94 +/- 0.86 cm, and mass of 62.36 +/- 1.07 kg. The 219 men had a mean age of 18.49 +/- 0.07 years, height of 183.24 +/- 1.68 cm, and mass of 88.05 +/- 1.82 kg. Sports participation included women's soccer, lacrosse, basketball, and field hockey; men's football, soccer, lacrosse, and wrestling; and women's and men's track and cheerleading. We used the Automated Neuropsychological Assessment Metrics (Army Medical Research and Materiel Command, Ft Detrick, MD) and measured throughput scores (the number of correct responses per minute) as the dependent variable for each subtest, with higher scores reflecting increased speed and accuracy of responses. Subsets included 2 simple reaction time (SRT) tests, math processing (MTH), Sternberg memory search (ST6), matching to sample pairs (MSP), procedural reaction time (PRO), code digit substitution (CDS), and the Stanford sleep scale Likert-type score. RESULTS Women scored better than men on the ST6 (P < .05), while men scored significantly better than women on the SRT and MSP tests. The highest-scoring SAT group performed better than other SAT groups on selected subtests (SRT, MTH, ST6, MSP, and CDS) (P < .05), and athletes tested during their season were more likely to score lower on the alertness scale (chi(2) (2)[n = 322] = 11.32, P = . 003). The lowest alertness group performed worse on the MSP and CDS subtests (P < .05). No differences were found between the group with a history of 1 or no concussion and the group with a history of 2 or more concussions (P > .05). CONCLUSIONS Performance on computerized neuropsychological tests may be affected by a number of factors, including sex, SAT scores, alertness at the time of testing, and the athlete's sport. To avoid making clinical misinterpretations, clinicians should acknowledge that individual baselines vary over time and should account for this variation.
Evolution of Social Organization and Life-History Patterns Among Grouse

Correlations of social structure, life-history patterns, and ecology among the seventeen species of grouse exemplify some general patterns in the evolution of mating systems among higher vertebrates. The species of grouse differ in the aggregation of displaying males, the permanence of heterosexual affiliations, the contributions of males to parental care, and the breeding sex ratio. Promiscous species (no durable heterosexual affiliation) are probably all polynous (the breeding sex ratio less than unity), but fall into two groups depending on whether the displaying males congregate at leks or disperse relatively evenly. In all of these promiscuous, polygymous species and in three monogramous species, the female cares for the young; dual parental care appears only in one monogamous species. During their first year, the males of polynous species do not mate or mate much less frequently, although females normally breed at one year of age, a situation termed sexual bimaturism. At least among birds and mammals, polygyny is normally associated with sexual bimaturism. Sexual bimaturism and polygyny among grouse correlated well both with large overall size, as indicated by female weight, and with greater sexual dimorphism in weight. These correlations also recur in other vertebrate families. Among the promiscuous grouse, the dispersion patterns of displaying males probably relate to the differences in predation pressures in open and forested habitats. In contrast with some other avian families, differences in social structure among grouse have little relationship to major differences in diet. Single parental care is not a sufficient condition for the evolution of polygyny among grouse. The association of sexual bimaturism with polygyny requires, in addition, an explanation of the adaptive advantages of deferred reproduction among males. Postponed reproduction by males will reduce the spread of their genes in a population unless compensated by a sufficient gain in early survival or increased fecundity later. Calculations of rates of reproductive increase for hypothetical lineages of males indicate that these compensating conditions can plausibly explain the evolution of delayed reproduction among male grouse. Theoretical considerations further suggest that larger size could favor the evolution of deferred reproduction, especially in males, and thus could contribute to the evolution of sexual bimaturism and polygyny in the larger species of grouse. Ecological circumstances, including the details of food dispersion, could thus influence the evolution of mating systems indirectly, through effects on the evolution of body sizes. As polygyny among higher vertebrates is normally associated with sexual bimaturism and is incompatible with full dual parental care, polygyny should evolve under ecological conditions in which the adaptive advantages of sexual bimaturism otuweigh those of dual parental care.
A comparison of the human papillomavirus test and Papanicolaou smear as a second screening method for women with minor cytological abnormalities.

BACKGROUND Of the estimated one million Papanicolaou (pap) smears performed annually in Sweden, about 4% show any degree of abnormality. Approximately, 1% of these cases contain moderate or severe atypia (high-grade squamous intraepithelial lesions) and the rest contain low-grade atypia. Recommendations for the management of minor abnormalities vary in various parts of Sweden. Generally, a second Pap smear is obtained 4-6 months after the first one showing low-grade atypia. The aim of this study is to compare the sensitivity of human papilloma virus (HPV)-DNA testing for the detection of cervical intraepithelial neoplasia (CIN) 2-3 with that of a second Pap smear in women, who had low-grade atypia in their first Pap smear. METHODS Women with low-grade atypia in the Stockholm area, detected at a population-based cytology screening, were enrolled. A repeat Pap smear, HPV test, and colposcopically directed biopsies were obtained. For the detection of HPV, Hybrid Capture II (HC II) was used. RESULTS The HPV-DNA test was positive in 66% of the 177 participating women. The sensitivity of the second Pap smear and HPV-DNA test to detect CIN 2-3 was 61 (95% CI = 45-74) and 82% (95% CI = 67-91), respectively. The positive and negative predictive values of HPV testing were 27 (95% CI = 18-35) and 89% (95% CI = 80-97), respectively. CONCLUSIONS In Sweden, a second Pap smear is often obtained for the follow-up of women with low-grade atypia. The results of our study show that compared to the second Pap smear, HPV testing with HC II is a more sensitive method for detecting high-grade lesions.
Disclosure of HIV Status and Sexual Orientation Independently Predicts Increased Absolute CD4 Cell Counts Over Time for Psychiatric Patients

Objective: The objective of this study was to replicate the relationship between disclosure of sexual orientation and immune functioning in HIV-positive persons and to extend those findings to a different type of disclosure (HIV status) and a different population (psychiatric outpatients in a publicly funded HIV/AIDS clinic). Methods: A sample of psychiatric outpatients (N = 373) from a large, urban HIV clinic was assessed for level of sexual orientation and HIV status disclosure as well as absolute CD4 cell counts over time. Mixed-effects random regression analysis was used to build a predictor model that included biobehavioral covariates. Results: Consistent disclosure of both sexual orientation and HIV status independently predicted increased CD4 cell counts over time controlling for important biobehavioral covariates. The only other significant effects in the model were baseline CD4 cell count and number of days between assessment of disclosure and assessment of CD4 cell count. Conclusions: Relieving potential psychological distress by disclosing sexual orientation and HIV status has a positive impact on CD4 cell counts over time even among outpatients stressed by psychiatric illness and economic disadvantage. Additional research is needed to understand whether and under what conditions disclosure should be part of HIV disease management. AIDS = acquired immune deficiency syndrome; BASIS-32 = Behavior and Symptom Identification Scale; HAART = highly active antiretroviral therapy; HIV = human immunodeficiency virus; MCS = Mental Component Summary; PCS = Physical Component Summary; RSO = Relationship to Self and Others; SO = sexual orientation.
Absolute cross-section measurements for electron-impact single ionization of Si4+ and Si5+

Experimental measurements of absolute cross sections are presented for electron-impact single ionization of Si[sup 4+] and Si[sup 5+]. The incident electron energies range from below threshold to 1500 eV. The measurements were performed using the crossed ion-electron beams apparatus at the Oak Ridge National Laboratory Electron-Cyclotron Resonance Ion-Source Facility. The data are in reasonable agreement with cross sections calculated using the Lotz semiempirical formula. Reduced cross sections for the isoelectronic targets, Si[sup 4+] and Ar[sup 8+], are compared in order to test classical scaling for direct electron-impact single ionization.
Detection of a novel DNA virus (TTV) sequence in peripheral blood mononuclear cells

DNA sequences of a novel DNA virus (TTV) were examined in 81 peripheral blood mononuclear cell (PBMC) DNA samples from 48 children and 33 adults, 22 cord blood mononuclear cells (CBMC) DNA samples, and 7 autopsy liver tissue DNA samples by a hemi‐nested polymerase chain reaction (PCR). The PCR was carried out using the published primers (NG059, NG061, NG063) to amplify TTV DNA sequences. The sequences were detected in 4 of 81 (5%) PBMC DNA samples, in none of 22 (0%) CBMC DNA samples, and in 2 of 7 (29%) liver tissue DNA samples by direct gel analysis. The PCR‐amplified products were confirmed by direct sequencing. The sequencing showed considerable diversities, with differences of 0–55% in 6 TTV isolates, compared with the prototype sequence of TTV. These results suggest that TTV is a ubiquitous virus that produces asymptomatic infection in a large proportion of the general population without transfusion of blood‐derived products. To our knowledge, this is the first report describing the detection of TTV DNA sequences in PBMCs. J. Med. Virol. 58:174–177, 1999. © 1999 Wiley‐Liss, Inc.
Maxillofacial Traumas in Farmers Caused by Farm Animals, Agricultural Vehicles, and Materials

Objective:It has been aimed at evaluating the relationship of maxillofacial fractures in farmers, which are caused due to traumas while working in farms, with trauma etiologies, maxillofacial fracture areas, age, sex, and seasonal variables. Methods:Among the farmers who have come to our emergency service unit as a result of maxillofacial trauma between 2010 and 2012, 146 patients have been analyzed retrospectively. The patients’ demographic findings, trauma etiologies, seasonal variables of trauma, and maxillofacial fracture area distribution have been analyzed. Results:Patients’ age varies between 12 and 80 and 87 of them are female (59.59%), while 59 are male (40.41%). The subjects’ etiological distribution is as follows: 47.5% is traumas caused by cattle among the farm animals; 15.75% is traumas caused by the blows of agricultural tools; 12.33% is traumas caused by tractor accidents; 9.59% is traumas caused by falling from haystacks; 7.53% is traumas caused by falling from agricultural vehicles, and 6.85% is traumas caused by horse kicks. When trauma etiology, age, sex, seasonal distribution, and the maxillofacial fractures were analyzed, statistically significant results have been determined. Conclusions:Although the number of maxillofacial traumas is considerably high in farmers due to farm animals, agricultural devices, and agricultural tools, while these traumas can cause functional and aesthetically minor fractures on the face, they can cause important and serious fractures as well. While knowing the mechanism of etiological fractures and accidents in different study groups can be guiding in the speedy diagnosis and treatment of possible fractures, it can also be helpful in taking precautions against traumas in these groups as well.
Localization of silencer and enhancer elements in the human type X collagen gene

Collagen type X is a short, network‐forming collagen expressed temporally and spatially tightly controlled in hypertrophic chondrocytes during endochondral ossification. Studies on chicken chondrocytes indicate that the regulation of type X collagen gene expression is regulated at the transcriptional level. In this study, we have analyzed the regulatory elements of the human type X collagen (Col10a1) by reporter gene constructs and transient transfections in chondrogenic and nonchondrogenic cells. Four different promoter fragments covering up to 2,864 bp of 5′‐flanking sequences, either including or lacking the first intron, were linked to luciferase reporter gene and transfected into 3T3 fibroblasts, HT1080 fibrosarcoma cells, prehypertrophic chondrocytes from the resting zone, hypertrophic chondrocytes, and chondrogenic cell lines. The results indicated the presence of three regulatory elements in the human Col10a1 gene besides the proximal promoter. First, a negative regulatory element located between 2.4 and 2.8 kb upstream of the transcription initiation site was active in all nonchondrogenic cells and in prehypertrophic chondrocytes. Second, a positive, but also non‐tissue‐specific positive regulatory element was present in the first intron. Third, a cell‐type‐specific enhancer element active only in hypertrophic chondrocytes was located between −2.4 and −0.9 kb confirming a previous report by Thomas et al. [(1995): Gene 160:291‐296]. The enhancing effect, however, was observed only when calcium phosphate was either used for transfection or included in the culture medium after lipofection. These findings demonstrate that the rigid control of human Col10a1 gene expression is achieved by both positive and negative regulatory elements in the gene and provide the basis for the identification of factors binding to those elements. J. Cell. Biochem. 66:210‐218, 1997. © 1997 Wiley‐Liss, Inc.
Psychological Component in the Etiology of Geographic Tongue

SYNOPSIS IN INTERLINGUA COMPONENTE PSYCHOLOGIC IN LE ETIOLOGIA DE LINGUA GEOGRAPHIC. — Sub) stress emotional, le linguas de 11 afficite studentes se pejorava e illos de 4 se meliorava. Le profilos medie de MMPI (Inventorio Multiphasic de Personalitate Minnesota) del afficite studentes esseva generalmente elevate in comparation con illos del subjectos de controlo. Duo de 35 subjectos de control e 15 de 35 afficite studentes habeva profilos de MMPI suggestive de disturbation psychologic. Le morbo esseva significativemente plus prevalente inter adultos mentalmente malade que inter adultos normal o mentalmente deficiente. Iste evidentia monstra que stress emotional es un factor etiologic in lingua geographic, sed investigationes additional es necessari pro determinar su importantia relative.
Hadrosaurs Were Perennial Polar Residents

Recent biomechanical evidence has fuelled debate surrounding the winter habits of the hadrosaurian dinosaur Edmontosaurus (ca. 70 Ma). Using histological characteristics recorded in bone, we show that polar Edmontosaurus endured the long winter night. In contrast, the bone microstructure of temperate Edmontosaurus is inconsistent with a perennially harsh environment. Differences in the bone microstructure of polar and temperate Edmontosaurus consequently dispute the hypothesis that polar populations were migratory. The overwintering signal preserved in the microstructure of polar Edmontosaurus bone offers significant insight into the life history of dinosaurs within the Late Cretaceous Arctic. Anat Rec, 2012. © 2012 Wiley Periodicals, Inc.