Miracle-dz/UniFAR-FTUs huggingface dataset:
Fuzzy k-Nearest Neighbors applied to phoneme recognition

In this work, the Fuzzy kNN (FkNN), an alternative of the standard kNN algorithm, is used for Timit phoneme recognition. Phoneme is the smallest unit that composes speech. For this reason, if phoneme recognition is performed, it can achieve a significant word and text recognition. Thus, the main idea consists on assigning phoneme membership to the data phonemes by measuring the distance to its kNN. FkNN compute the fuzzy distances between the data phonemes that define the cluster fuzziness. Mel Frequency Cepstral Coefficients (MFCC) associated with their first and second derivatives and energy coefficient were extracted from the speech signals as an input of the recognition system. A comparison of a crisp and fuzzy kNN was performed. Experiments show that FkNN algorithm not only can lead to significant recognition rates, but also may supersede in some ways Hidden Markov Model (HMM) the reference of speech recognition.
Global Birth Hypoxia Increases the Neonatal Testosterone Surge in the Rat

Background/Aims: Global birth hypoxia in rats has been shown to produce long-term changes in central nervous system functions, known to be influenced by neonatal testosterone secretion. Birth hypoxia alters levels of several circulating hormones, but it is unknown if it affects neonatal testosterone. Methods: Using a rat model of acute global hypoxia during cesarean section (C-section) birth, this study tested whether birth hypoxia affects neonatal testosterone. We then evaluated whether the observed hypoxia-induced changes in neonatal testosterone may be mediated via N-methyl-D-aspartate (NMDA) receptor activation and/or altered luteinizing hormone (LH), adrenocorticotropic hormone (ACTH) or corticosterone levels. Longer-term effects of birth hypoxia on testosterone-related function were also assessed. Results: Rats born by C-section + 15 min of anoxia had significantly higher plasma testosterone at 2 and 3 h after birth compared to controls born either vaginally or by C-section. Administration of an NMDA receptor antagonist at birth increased neonatal testosterone in both anoxic pups and controls. Pups exposed to birth anoxia under hypothermic conditions also showed increased neonatal testosterone. Circulating LH, follicle-stimulating hormone and corticosterone in neonates, and testosterone at adulthood were unaffected by birth hypoxia. However, plasma ACTH was significantly increased in anoxic neonates at 2 h after birth. Birth condition had no effect on anogenital distance or juvenile play behavior. Conclusion: It is concluded that birth hypoxia augments plasma testosterone during the critical period of the neonatal testosterone surge, by a mechanism that is independent of NMDA-mediated LH secretion, but may involve increased circulating ACTH.
A comparison of the ratio of patient's height to thyromental distance with the modified Mallampati and the upper lip bite test in predicting difficult laryngoscopy

Background: The aim of the present study was to compare the ability to predict difficult visualization of the larynx from the following preoperative airway predictive indices, in isolation and combination: modified Mallampati test (MMT), the ratio of height to thyromental distance (RHTMD) and the Upper-Lip-Bite test (ULBT). Methods: We collected data on 603 consecutive patients scheduled for elective surgery under general anesthesia requiring endotracheal intubation and then evaluated all three factors before surgery. An experienced anesthesiologist, not informed of the recorded preoperative airway evaluation, performed the laryngoscopy and grading (as per Cormack and Lehane's classification). Sensitivity, specificity, and positive and negative predictive value, Receiver operating characteristic (ROC) Curve and the area under ROC curve (AUC) for each airway predictor in isolation and in combination were determined. Results: Difficult laryngoscopy (Grade 3 or 4) occurred in 41 (6.8%) patients. The main endpoint of the present study, the AUC of the ROC, was significantly lower for the MMT (AUC, 0.511; 95% CI, 0.470–0.552) than the ULBT (AUC, 0.709; 95% CI, 0.671–0.745, P=0.002) and the RHTMD score (AUC, 0.711; 95% CI, 0.673–0.747, P=0.001). There was no significant difference between the AUC of the ROC for the ULBT and the RHTMD score. By using discrimination analysis, the optimal cutoff point for the RHTMD for predicting difficult laryngoscopy was 21.06 (sensitivity, 75.6%; specificity, 58.5%). Conclusion: The RHTMD is comparable with ULBT for prediction of difficult laryngoscopy in general population.
The use of histological and immunohistochemical markers to distinguish pleural malignant mesothelioma and in situ mesothelioma from reactive mesothelial hyperplasia and reactive pleural fibrosis

Distinguishing malignant mesothelioma from reactive mesothelial hyperplasia and reactive fibrosis can be a diagnostic problem in small pleural biopsies, made more difficult by the recent recognition of mesothelioma‐in‐situ. Antibodies to epithelial membrane antigen (EMA), p53, and bcl‐2 have all been advocated for differentiating reactive from neoplastic conditions, but reports are inconsistent. These antibodies have therefore been applied to 31 cases of malignant mesothelioma, 34 cases of reactive pleural disease (20 reactive mesothelial hyperplasia and 14 reactive pleural fibrosis) and four small biopsies that were initially coded as suspicious, from patients who later developed frank mesothelioma. Thirty out of 31 (97 per cent) cases of mesothelioma showed positive nuclear staining for p53, with a higher incidence of positivity in epithelioid than in sarcomatoid elements and 30/31 (97 per cent) showed diffuse linear membrane staining for EMA, again more intense in the epithelioid elements. No mesothelioma was positive for bcl‐2. In seven cases that contained both in situ and invasive mesothelioma, the in situ elements showed similar staining patterns to the invasive epithelioid elements. Thirteen out of 20 (65 per cent) cases of reactive mesothelial hyperplasia showed occasional nuclear positivity for p53 and 5/20 (25 per cent) cases showed focal weak membrane staining for EMA. Three out of 14 (21 per cent) cases of reactive pleural fibrosis showed positive nuclear staining for p53 and 6/14 (43 per cent) cases showed focal membrane staining with EMA. No reactive cases stained for bcl‐2. All four suspicious cases showed diffuse linear staining with EMA and three showed focal staining for p53. It is concluded that strong diffuse linear staining for EMA is a good marker of malignancy when differentiating epithelioid malignant mesothelioma and mesothelioma‐in‐situ from reactive mesothelial hyperplasia, although weak focal staining may occur in reactive conditions. Nuclear staining for p53 is also suggestive of epithelioid mesothelioma, but should be regarded as no more than suspicious. The antibodies used in this investigation are less helpful in differentiating sarcomatoid mesothelioma from reactive pleural fibrosis. Copyright © 1999 John Wiley & Sons, Ltd.
Efficacy of escalating doses of liposomal amphotericin B (AmBisome) against hematogenous Candida lusitaniae and Candida krusei infection in neutropenic mice

Immunosuppressed CF1 mice were infected intravenously with two strains of Candida krusei and four strains of Candida lusitaniae (two of which were resistant to amphotericin B). Mice were treated with 1 or 2 mg of amphotericin B desoxycholate per kg of body weight per day or escalating doses of liposomal amphotericin B (8 to 30 mg/kg/day) or were left untreated. Higher doses of liposomal amphotericin B were as effective as standard dose of amphotericin B desoxycholate in prolonging survival but were significantly more effective in reducing the fungal burden in the kidneys of animals infected with both C. krusei strains and the C. lusitaniae strains that were susceptible to amphotericin B desoxycholate. This advantage of liposomal amphotericin B therapy could not be demonstrated in mice infected with the C. lusitaniae strains that were resistant to amphotericin B desoxycholate.
A Novel Nucleus-Encoded Chloroplast Protein, PIFI, Is Involved in NAD(P)H Dehydrogenase Complex-Mediated Chlororespiratory Electron Transport in Arabidopsis12[W][OA]

A transient rise in chlorophyll fluorescence after turning off actinic light reflects nonphotochemical reduction of the plastoquinone (PQ) pool. This process is dependent on the activity of the chloroplast NAD(P)H dehydrogenase (NDH) complex, which mediates electron flow from stromal reductants to the PQ pool. In this study, we characterized an Arabidopsis (Arabidopsis thaliana) T-DNA insertion mutant pifi (for postillumination chlorophyll fluorescence increase), which possesses an intact NDH complex, but lacks the NDH-dependent chlorophyll fluorescence increase after turning off actinic light. The nuclear gene PIFI (At3g15840) containing the T-DNA insertion encodes a chloroplast-targeted protein localized in the stroma and is annotated as a protein of unknown function. The pifi mutant exhibited a lower capacity for nonphotochemical quenching, but similar CO2 assimilation rates, photosystem II (PSII) quantum efficiencies (ΦPSII), and reduction levels of the primary electron acceptor of PSII (1 − qL) as compared with the wild type. The pifi mutant grows normally under optimal conditions, but exhibits greater sensitivity to photoinhibition and long-term mild heat stress than wild-type plants, which is consistent with lower capacity of nonphotochemical quenching. We conclude that PIFI is a novel component essential for NDH-mediated nonphotochemical reduction of the PQ pool in chlororespiratory electron transport.
Virtual screening approach to identifying influenza virus neuraminidase inhibitors using molecular docking combined with machine-learning-based scoring function

In recent years, an epidemic of the highly pathogenic avian influenza H7N9 virus has persisted in China, with a high mortality rate. To develop novel anti-influenza therapies, we have constructed a machine-learning-based scoring function (RF-NA-Score) for the effective virtual screening of lead compounds targeting the viral neuraminidase (NA) protein. RF-NA-Score is more accurate than RF-Score, with a root-mean-square error of 1.46, Pearson’s correlation coefficient of 0.707, and Spearman’s rank correlation coefficient of 0.707 in a 5-fold cross-validation study. The performance of RF-NA-Score in a docking-based virtual screening of NA inhibitors was evaluated with a dataset containing 281 NA inhibitors and 322 noninhibitors. Compared with other docking–rescoring virtual screening strategies, rescoring with RF-NA-Score significantly improved the efficiency of virtual screening, and a strategy that averaged the scores given by RF-NA-Score, based on the binding conformations predicted with AutoDock, AutoDock Vina, and LeDock, was shown to be the best strategy. This strategy was then applied to the virtual screening of NA inhibitors in the SPECS database. The 100 selected compounds were tested in an in vitro H7N9 NA inhibition assay, and two compounds with novel scaffolds showed moderate inhibitory activities. These results indicate that RF-NA-Score improves the efficiency of virtual screening for NA inhibitors, and can be used successfully to identify new NA inhibitor scaffolds. Scoring functions specific for other drug targets could also be established with the same method.
Telephonic nurse case management for patients with diabetes and mental illnesses: a qualitative perspective

Objectives: Gold Choice, a partially capitated Medicaid managed care programme for individuals with a behavioural health diagnosis, implemented a telephonic nurse case management (TNCM) programme to improve diabetes self-management. We sought to identify issues faced by patients with co-morbid behavioural health diagnoses and diabetes as documented in the telephonic nurse case manager’s progress notes. We also explored the role of the TNCM in addressing members’ needs. Methods: We undertook a qualitative analysis of 853 de-identified progress notes from 539 Gold Choice members and conducted a semi-structured interview with the TNCM. Results: Seven major themes emerged reflecting the nurse’s perspectives on challenges faced by Gold Choice members and addressed by the TNCM: (1) Transience of the population. (2) Complex needs, involving not only medical and psychiatric conditions but also housing, transportation and survival. (3) Confusion regarding diabetes diagnosis. (4) Mistrust and suspicion. (5) Difficulties with medical care. (6) Need for diabetes self-management education/skills. (7) Marked appreciation that the TNCM would initiate contact and care about the patient. Discussion: Members with co-morbid behavioural health diagnoses and diabetes constitute a complex population with extensive needs. The TNCM’s role extends beyond diabetes care and entails social support as well as navigation of the healthcare and social service systems.
Systemic Proliferative Changes and Clinical Signs in Cynomolgus Monkeys Administered a Recombinant Derivative of Human Epidermal Growth Factor

Epidermal growth factor (EGF) effects have been explored extensively in vivo in rodents, but little is known about trophic responses in nonhuman primates. A previous publication reports the hyperplastic epithelial/parenchymal changes noted in the digestive tract (tongue, esophagus, stomach, intestine, liver, gallbladder, pancreas, and salivary glands) of adult cynomolgus monkeys treated with recombinant human EGF1-48 (rhEGF1-48). This report documents clinical findings and structural effects in the remaining epithelium-containing tissues of these animals. Two monkeys/sex/dose received rhEGF1-48 by intravenous bolus at 0 (vehicle), 10, 100, 500 (females only), or 1,000 μg/kg/day (males only) daily for up to 2 weeks. Treatment- and dose-related clinical findings included emesis, fecal alterations (soft feces and diarrhea), lacrimation, nasal discharge, hypoactivity, transient hypotension, and salivation after dosing. Male monkeys administered 1000 μg/kg became moribund after 5 days of treatment and were necropsied. All other monkeys completed the 2-week treatment period. Necropsy findings in nongastrointestinal tissues were: enlarged, pale kidneys at 100 μ g/kg and greater; small thymuses seen sporadically at all doses; and enlarged adrenals and small thyroids in males at 1,000 μg/kg. Respective organ-to-brain weight ratios at 500 and 1,000 μg/kg for kidneys were 1.5- and 2.6-fold greater and for heart were 1.7- and 1.3-fold greater than controls. Microscopically, pronounced dose-related epithelial hypertrophy and hyperplasia were evident in kidney, urinary bladder, skin (epidermis and adnexa), mammary gland, prostate, seminal vesicles, epididymis, uterus, cervix, vagina, thyroid, thymus, tonsillar crypts, cornea, trachea, and pulmonary airways. Epitheliotrophic effects were conspicuous in many tissues at 100 to 1,000 μg/kg. Changes to renal collecting ducts were present at 10μg/kg, suggesting that kidneys were a relatively sensitive target. Proliferative alterations were not apparent in testes, intraocular structures, brain ependyma and choroid plexus at any dose. Aside from the noted exceptions, rhEGF1-48 was a pantrophic epithelial mitogen in cynomolgus monkeys when used intravenously at suprapharmacologic doses.
Legal Empowerment and Group-Based Inequality

Abstract Legal empowerment has become widely accepted in development policy circles as an approach to addressing poverty and exclusion. At the same time, it has received relatively little attention from political scientists and sociologists working on overlapping and closely related topics – the rule of law, the functioning of judicial systems, property rights, labour politics, and business and governance, among others. Research on legal empowerment has been largely applied, with clearest grounding in the fields of law and economics. This special issue speaks to this gap with contributions on six core areas of legal empowerment. This article frames the collection. It provides a brief introduction to legal empowerment and advances two broad arguments. First, an ethnic group-focused approach is a useful starting point in considering the impact of legal empowerment and other development interventions. Second, the state via the law contributes to ethnic inequalities in four broad ways – via its written laws, their implementation and actual practice, historical legacies of law and practice, and ethnic hegemony embedded in the system. Thinking about legal empowerment initiatives within this framework provides understanding both of their potential and their limitations.
Refractory knee giant cell tumor of the synovial membrane treated with intra‐articular injection of Infliximab: a case series and review of the literature

Giant cell tumor (GCT) of the synovial membrane, also known as pigmented villonodular synovitis, causes a progressive, relapsing and destructive arthropathy affecting one or more synovial joints. Systemic therapy can be combined to intra‐articular treatments, including surgical synoviectomy, especially when monoarticular. Despite that, the synovial membrane commonly grows again with clinical relapse. Here, we report three case of patients diagnosed with GCT of the knee who had an early relapse of the disease even after surgical synoviectomy. All of them underwent intra‐articular therapy with infliximab and subsequent synoviectomy to eradicate residual tissue. A complete remission of CGT was achieved without relapse occurring during the follow‐up. These preliminary data need to be confirmed by further clinical trials; however, intra‐articular therapy with infliximab might be deemed a potential option to treat CGT of a single joint.
Academic Dishonesty Among Accounting Students: Some Indonesian Evidence

Academic dishonesty among students has been recognised as a major concern in higher education in Indonesia. Accounting research arguably need to give more attention to this issue. This is partly because of the importance of integrity as part of accounting ethics and professionalism. However, little currently known about academic dishonesty among accounting students in Indonesia. We address this issue by surveying 342 accounting students about their perception of academic dishonesty and what motivates such behaviour. Our respondents were from all first, second or third year undergraduate students at one state university in Indonesia. Drawing from Theory of Planned Behaviour, we examine three individual variables - attitude, subjective norms, and perceived behavioural control. In addition, we also examine three situational variables - academic integrity culture, definitional ambiguity, and pressure. Six hypotheses were tested, using a Partial Least Squares-Structural Equation Modelling. The results reveal that 77.5% of respondents admitted committing academic dishonesty. While all individual factors studies have positive significant effect on the intention to commit academic dishonesty, of the three situational factors only pressure and definitional ambiguity have a positive significant effect. Surprisingly, it is found that academic integrity culture does not have a significant effect.
Exposure to 50 Hz Magnetic Fields in Homes and Areas Surrounding Urban Transformer Stations in Silla (Spain): Environmental Impact Assessment

Exposure to extremely low frequency electromagnetic fields (ELFs) is almost inevitable almost anywhere in the world. An ELF magnetic field (ELF-MF) of around 1 mG = 0.1 μT is typically measured in any home of the world with a certain degree of development and well-being. There is fear and concern about exposure to electromagnetic fields from high- and medium-voltage wiring and transformer stations, especially internal transformer stations (TSs), which in Spain are commonly located inside residential buildings on the ground floor. It is common for neighbors living near these stations to ask for stations to be moved away from their homes, and to ask for information about exposure levels and their effects. Municipality is the closest administration to the citizens that must solve this situation, mediating between the citizens, the utility companies and the national administration. In this case, the municipality of Silla (València, Spain) wanted to know the levels of exposure in the dwellings annexed to the TSs, to compare them with Spanish legislation and the recommendations coming from epidemiological studies. This article presents the first systematic campaign of ELF-MF measurements from TSs carried out in a Spanish city. Many measurements were carried out in the rooms of the apartments doing spatial averages of spatial grid measurements. Measurements are made in the bed and bedrooms and a weighted average and an environmental impact indicator were obtained for each location. We found that old TSs usually provide the highest peak exposure levels. A notable result of this work is that approximately one quarter of the population living above or next to a TS would be exposed to a weighted MF level greater than 0.3 μT, and that about a 10% of this population would not be able to relocate their bedroom or living room to minimize the level of exposure.
Morphometric Study of the Lumbar Pedicle in the Indian Population as Related to Pedicular Screw Fixation

Study Design. A morphometric study of lumbar vertebral pedicular parameters in cadavers and comparison with previous studies in the literature was conducted. Objectives. To suggest dimensions for pedicular implants in the Indian population, and to improve the pedicular screw placement technique. Summary of Background Data. Detailed knowledge of pedicle morphometry is critical for proper placement of a transpedicular screw. The size and shape of the vertebral pedicle vary between different races. Morphometric studies have been conducted in white and nonwhite populations (e.g., Chinese, Koreans). Methods. The vertebral pedicles at L1–L5 were studied in 20 cadavers by direct roentgenographic and computerized tomographic scan methods. The following parameters were studied: transverse diameter, transverse angle, sagittal diameter, sagittal angle, chord length, interpedicular distance, medial and lateral cortical thickness. Results. Transverse diameter was largest at L5 (16.19 mm) and smallest at L1 (7.05 mm). The transverse angle was largest at L5 (29°) and smallest at L1 (9°). The pedicles were directed cranially in the sagittal plane at all lumber levels except L5. The sagittal angle was largest at L5 (29°) and smallest at L1 (9°). Chord length was largest at L2 (47.5 mm) and smallest at L1 (46.01 mm). The values of linear measurements were smaller in females at all levels. Conclusions. On the basis of this limited study in a subset of the Indian population, it appears that the transverse diameter and pedicle entrance point differ from those in the white population. The results suggest that a 5-mm screw would be safer in the upper lumbar levels (L1, L2), and 6-mm screw in the lower lumbar levels (L3–L5). The pedicle entrance point migrates laterally for lower lumbar levels, especially at L5. The medial pedicle cortex can be safely sounded while the pedicle is probed.