Miracle-dz/UniFAR-FTUs huggingface dataset:
PIPE 3 : A MASSIVELY PARALLEL PROTEIN-PROTEIN INTERACTION PREDICTION ENGINE by

Protein-protein interactions play a key role in many human diseases. A detailed knowledge of protein-protein interactions will accelerate the drug discovery process as well as reduce overall drug development costs. Biologists have a variety of methods to determine protein-protein interactions in the labratory, however these approaches are generally expensive, labour intensive, time consuming and have significantly high error rates. The Protein-protein Interaction Prediction Engine (PIPE) is a computational approach to prediction protein-protein interactions. The first version of PIPE proved that the underlying hypothesis that PIPE is built upon had merit. The second version of PIPE was a vast improvement over the first version and proved that a prediction over all possible yeast protein pairs was possible, however still had room for major improvements. The two major limitations of the PIPE2 implementation was that it was not very efficient with its memory use and it did not scale well due to a lack of a real parallel architecture. This thesis presents PIPE3, a new version of PIPE designed to overcome the downfalls of the earlier versions. A new parallel architecture consisting of a mixed master/slave and all-slaves model was designed and implemented to address these issues. This overall approach exploits parallelism on two levels, the first by running multiple PIPE threads on a given cluster node and secondly by running many of these processes on different cluster nodes, all being fed work in an on-demand fashion. PIPE3’s parallel architecture performed well overall. The all-slaves portion of the parallel architecture produced a significant speedup and the master/slave portion of the parallel architecture resulted in a linear speedup when more cluster nodes were used. PIPE3 was then used to produce some significant scientific results. These include a proteomewide scan on the Caenorhabditis Elegans and Homo Sapiens organisms, which also resulted in the largest threaded calculation ever run at the High Performance Computing Virtual Laboratory (HPCVL).
Isotopic Evidence for Marine Consumption and Mobility in the Atacama Desert (Quillagua, Northern Chile)

Archaeological research in the Atacama Desert has recovered evidence of considerable cultural variability. This variability seems to have increased during the Late Intermediate Period (AD 950–1400). The oasis of Quillagua, located at the margins of the Loa River in northern Chile, between the Andes and the coast (70 km from the Pacific Ocean), has shown important evidence regarding this cultural diversity. The variety in the archaeological evidence found at Quillagua has been interpreted as the result of two different cultural influences at the oasis: the Pica-Tarapaca who occupied the coastal and inland regions to the north of Quillagua and the Atacama who occupied the oasis and fertile areas southeast of Quillagua. Here, we present the results of stable carbon, nitrogen and oxygen isotope analyses of 23 individuals recovered from the Cementerio Oriente in Quillagua, in order to test whether the observed cultural variability is also reflected in diet and mobility patterns. Results from carbon and nitrogen isotope measurements indicate the importance of marine protein, as well as a contribution of maize in the diet of some individuals. Four individuals show low δ18O values, suggesting a possible highland or non-local origin, whereas values for the remaining individuals are consistent with lowland populations. Together, the results support the idea that the Quillagua oasis represented an important site of interaction between the Tarapaca and Atacama cultures, with close contacts with the coast but also with the presence of individuals from the highlands. Copyright © 2015 John Wiley & Sons, Ltd.
Pharyngeal biting mechanics in centrarchid and cichlid fishes : insights into a key evolutionary innovation

This study compares the pharyngeal biting mechanism of the Cichlidae, a family of perciform fishes that is characterized by many anatomical specializations, with that of the Centrarchidae, a family that possesses the generalized perciform anatomy. Our objective was to trace the key structural and functional changes in the pharyngeal jaw apparatus that have arisen in the evolution from the generalized to derived (cichlid) perciform condition. We propose a mechanical model of pharyngeal biting in the Centrarchidae and compare this with an already existing model for pharyngeal biting in the family Cichlidae. Central to our centrarchid model is a structural coupling between the upper and lower pharyngeal jaws. This coupling severely limits independent movement of the pharyngeal jaws, in contrast to the situation in the speciose Cichlidae, in which the upper and lower pharyngeal jaw movements are to a large extent independent. We tested both models by electrically stimulating nine muscles of the branchial and hyoid apparatuses in three centrarchid and three cichlid species. The results confirmed the coupled movement of the upper and lower pharyngeal jaws in the Centrarchidae and the independence of these movements in the Cichlidae. We suggest that the key structural innovation in the development of the functionally versatile cichlid (labroid) pharyngeal jaw apparatus was the decoupling of epibranchials 4 from the upper pharyngeal jaws. This structural decoupling implies * Author for correspondence.
What Can Superconducting Gravimeters Contribute to Normal-Mode Seismology?

The seismic free oscillations of the Earth can be observed in the frequency band from 0.3 to 20 mHz, and estimates of their frequencies constitute the principal constraints for spherically symmetric Earth models such as the Preliminary Reference Earth Model (PREM). While the bulk of the mode observations rely on recordings of the spring gravimeters deployed in the International Deployment of Accelerometers (IDA) network and more recently on the Streckiesen STS-1 seismometers deployed in the global seismic network (GSN), we show here that the most recent generation of superconducting gravimeters (SGs) can achieve lower noise levels than either one of the aforementioned sensors at frequencies lower than ∼0.8 mHz. While the splitting of modes above 1 mHz is largely due to structural heterogeneities in P - and S -wave velocities, the modes below 1 mHz are unique for two reasons: (1) the destabilizing effect of self-gravitation leads to a high sensitivity to density heterogeneities and (2) the vicinity of these modes to the frequency of the Earth9s rotation leads to pronounced Zeeman splitting, which in turn depends on spherically averaged density structure. Thus it is argued that SGs can make a significant contribution to the illumination of long-wavelength density heterogeneities in the Earth9s mantle. At frequencies above 1 mHz, current SGs exhibit higher noise levels than the quietest seismometers deployed in the GSN. Furthermore we show that above 3 mHz, even the Streckeisen STS-2 seismometers compare favorably against the SGs if the former are installed with elaborate shielding from environmental effects.
On the metaphorical nature of intellectual capital: a textual analysis

Purpose – To analyse common metaphors used in the intellectual capital (IC) and knowledge management literatures to conceptualise knowledge, in order to study the nature of the intellectual capital concept.Design/methodology/approach – A textual analysis methodology is used to analyse texts from The Knowledge‐Creating Company by Nonaka and Takeuchi, Working Knowledge by Davenport and Prusak and “Brainpower” by Stewart, in order to identify underlying metaphors.Findings – Over 95 per cent of the statements about knowledge identified are based on some kind of metaphor. The two dominant metaphors that form the basis for the concept of intellectual capital are “knowledge as a resource” and “knowledge as capital”. Research limitations/implications – Metaphors highlight certain characteristics and ignore others, so the IC community should ask itself what characteristics of knowledge the “knowledge as a resource” and “knowledge as capital” metaphors ignore.Practical implications – Knowledge has no referent in the.
Human epithelial growth factor receptor 2 in human salivary carcinoma ex pleomorphic adenoma: a potential therapeutic target

Background To inhibit human epithelial growth factor receptor 2 (HER2) in salivary carcinoma ex pleomorphic adenoma (CXPA) and investigate the effects on tumor cell proliferation, cell cycle, and apoptosis. To assess the possibility of blocking HER2 to improve the malignant biological behavior of CXPA. Materials and methods HER2 expression and amplification were examined using an immunofluorescence assay and fluorescence in situ hybridization in 2 CXPA cell lines (SM-AP1 and SM-AP4 cells). The effects on tumor cell proliferation, cell cycle, apoptosis, and HER2 downstream pathways were verified after the application of a HER2 inhibitor. Results HER2 was overexpressed and amplified in SM-AP1 and SM-AP4 cell lines. After blocking HER2, the tumor proliferation and cell cycle were significantly induced, and the apoptosis process was activated. Moreover, the downstream pathways PI3K/AKT and MAPK/ERK were significantly inhibited. Conclusion HER2 was overexpressed and amplified in CXPA cell lines and might thus play an important role in tumor development. Inhibiting HER2 may be a novel targeted therapy for poor biological behavior of CXPA.
A comparison of qualitative and quantitative methods of detecting earnings management: evidence from two Fijian private and two Fijian state-owned entities

This paper compares the performance-matched discretionary accrual model (quantitative) and the Mulford and Comiskey (2002) qualitative measure to compute earnings management in two state-owned and two private entities for 1998 to 2009. The results provide evidence that the two measures are unable to provide similar results for the existence of earnings management. The difference in the results between the two methods is attributed to the different ontological and epistemological views and the primary focus of the respective models. The results do not imply superiority of any model.
Proximal Tubule Function and Free Water Clearance: Comparison between Healthy Elderly and Young HIV+ Patients

In previous studies it was documented that proximal tubule sodium reabsorption capability was preserved in healthy elderly, while Thick Ascending Loop of Henle (TALH) one was reduced. Aim: Since, it has also been documented that senile changes are accelerated in HIV patients, we performed a prospective study in order to evaluate if there was a significant difference in proximal and TALH function between healthy elderly and HIV patients. Methods: Proximal and TALH was analyzed by performing hyposaline infusion test in 10 young (≥ 18-≤ 40 years old) HIV volunteers under treatment with tenofovir, free of viral charge, and normal renal function: serum creatinine, urinary sediment, and renal ultrasound), with the control group made up of 10 healthy old volunteers (≥ 65 years old). Results: During the test, it was observed that the HIV group had a significant reduction of natremia (HIV: 133 ± 1 mmol/l vs. healthy elderly: 139 ± 1 mmol/l, p=0.03), serum osmolarity (HIV: 276 ± 4 mOsm/l vs. elderly: 288 ± 3 mOsm/l, p=0.03) and free water clearance (HIV: 3.5 ± 3 ml/min/1.73 m² vs. elderly: 5 ± 8 ml/min/1.73 m², p ≤ 0.01). Besides, HIV patients showed an inadequate and significant increase in their urinary tonicity in comparison with the healthy elderly group: HIV: 170 ± 18 mOsm/l vs. elderly: 90 ± 10, p ≤ 0.01. Regarding proximal tubular function, it was found that it was preserved in both groups. Conclusion: Proximal tubule sodium reabsorption was normal, while free water clearance was significantly reduced in young HIV patients in comparison with healthy elderly volunteers.
Influences of Internal and External Frames of Reference on Math and Verbal Self-concepts for Gifted and Non-gifted Tenth Grade Students

This study explores the relationship between mathematics and English achievement and mathematics and verbal self-concept and investigates whether these relationships are invariant with respect to student ability and gender. Data from 16,033 10th grade students who completed both the base and the first follow-up student questionnaire of the National Education Longitudinal Study (NELS) of 1988 were used in this study. Findings indicate that math and verbal self-concepts are substantially less correlated than math and English achievement; individual level math (English) achievement has a positive, direct effect on math (verbal) self-concept but a negative, direct effect on verbal (math) self-concept; and school level math (English) achievement has a negative effect on math (verbal) self-concept but not on verbal (math) self-concept. These findings were found to be invariant across males and females as well as gifted and non-gifted students; however, statistically significant gender differences and giftedness differences were found in the correlations between math and verbal self-concepts. Higher correlations were found to exist between math self-concept and verbal self-concept for males than for females and for gifted than for non-gifted students. Contains 76 references. (Author/JRH) ******************************************************************************** Reproductions supplied by EDRS are the best that can be made from the original document. ******************************************************************************** PERMISSION TO REPRODUCE AND DISSEMINATE THIS MATERIAL HAS BEEN GRANTED BY TO THE EDUCATIONAL RESOURCES INFORMATION CENTER (ERIC) U.S. DEPARTMENT OF EDUCATION Office of Educational Research and Improvement EDUCATIONAL RESOURCES INFORMATION CENTER (ERIC) This document has been reproduced as ived from the person or organization originating it. Minor changes have been made to improve reproduction quality, Points of view or opinions stated in this document do not necessarily represent official OERI position or policy. Influences of Internal and External Frames of Reference on Math and Verbal Self-concepts for Gifted and Non-gifted Tenth Grade Students Wan li Zhang, Francis X. Archambault, Jr., Steven V. Owen, Jonna M. Kulikowich University of Connecticut Paper presented at the 1997 American Educational Research Association (AERA) Annual Meeting. Chicago, March 1997.
Impacts of Self-efficacy on Perceived Feasibility and Entrepreneurial Intentions: Empirical Evidence from China

This paper presents a structural equation model of entrepreneurial intentions as influenced by self-efficacy and perceived feasibility. In this paper self-efficacy refers to a kind of subjective perception and belief that the farmers complete the entrepreneurial activities on the basis of their capacity defined as entrepreneurial self-efficacy, which measured by five dimensions including resource acquisition, opportunity recognition, interpersonal relations, risk management, innovation management. The main findings are that most farmers appear to have a remarkable degree of entrepreneurial intentions; besides, self-efficacy has a significant and positive impact on farm households’ entrepreneurial intentions, and the effect is 0.669; furthermore, perceived feasibility of farmers play a significant role on entrepreneurial intentions; finally, the perceived feasibility of farmers has a partial mediating effect between entrepreneurial self-efficacy and the entrepreneurial intentions.