Miracle-dz/UniFAR-FTUs huggingface dataset:
CNS involvement in V30M transthyretin amyloidosis: clinical, neuropathological and biochemical findings

Objectives Since liver transplant (LT) was introduced to treat patients with familial amyloid polyneuropathy carrying the V30M mutation (ATTR-V30M), ocular and cardiac complications have developed. Long-term central nervous system (CNS) involvement was not investigated. Our goals were to: (1) identify and characterise focal neurological episodes (FNEs) due to CNS dysfunction in ATTR-V30M patients; (2) characterise neuropathological features and temporal profile of CNS transthyretin amyloidosis. Methods We monitored the presence and type of FNEs in 87 consecutive ATTR-V30M and 35 non-ATTR LT patients. FNEs were investigated with CT scan, EEG and extensive neurovascular workup. MRI studies were not performed because all patients had cardiac pacemakers as part of the LT protocol. We characterised transthyretin amyloid deposition in the brains of seven ATTR-V30M patients, dead 3–13 years after polyneuropathy onset. Results FNEs occurred in 31% (27/87) of ATTR-V30M and in 5.7% (2/35) of the non-ATTR transplanted patients (OR=7.0, 95% CI 1.5 to 33.5). FNEs occurred on average 14.6 years after disease onset (95% CI 13.3 to 16.0) in ATTR-V30M patients, which is beyond the life expectancy of non-transplanted ATTR-V30M patients (10.9, 95% CI 10.5 to 11.3). ATTR-V30M patients with FNEs had longer disease duration (OR=1.24; 95% CI 1.07 to 1.43), renal dysfunction (OR=4.65; 95% CI 1.20 to 18.05) and were men (OR=3.57; 95% CI 1.02 to 12.30). CNS transthyretin amyloidosis was already present 3 years after polyneuropathy onset and progressed from the meninges and its vessels towards meningocortical vessels and the superficial brain parenchyma, as disease duration increased. Conclusions Our findings indicate that CNS clinical involvement occurs in ATTR-V30M patients regardless of LT. Longer disease duration after LT can provide the necessary time for transthyretin amyloidosis to progress until it becomes clinically relevant. Highly sensitive imaging methods are needed to identify and monitor brain ATTR. Disease modifying therapies should consider brain TTR as a target.
Headache in a Population‐Based Elderly Cohort. An Ancillary Study to the Italian Longitudinal Study of Aging (ILSA)

The aims of this ancillary study to the Italian Longitudinal Study of Aging were: (1) to provide reliable prevalence data on headache in an elderly population, (2) to classify the subtypes of headache according to International Headache Society criteria, and (3) to identify possible risk factors and associated pathologies in the elderly.
Transient Lymphopenia Breaks Costimulatory Blockade‐Based Peripheral Tolerance and Initiates Cardiac Allograft Rejection

Lymphopenia is induced by lymphoablative therapies and chronic viral infections. We assessed the impact of lymphopenia on cardiac allograft survival in recipients conditioned with peritransplant costimulatory blockade (CB) to promote long‐term graft acceptance. After vascularized MHC‐mismatched heterotopic heart grafts were stably accepted through CB, lymphopenia was induced on day 60 posttransplant by 6.5 Gy irradiation or by administration of anti‐CD4 plus anti‐CD8 mAb. Long‐term surviving allografts were gradually rejected after lymphodepletion (MST = 74 ± 5 days postirradiation). Histological analyses indicated signs of severe rejection in allografts following lymphodepletion, including mononuclear cell infiltration and obliterative vasculopathy. Lymphodepletion of CB conditioned recipients induced increases in CD44high effector/memory T cells in lymphatic organs and strong recovery of donor‐reactive T cell responses, indicating lymphopenia‐induced proliferation (LIP) and donor alloimmune responses occurring in the host. T regulatory (CD4+ Foxp3+) cell and B cell numbers as well as donor‐specific antibody titers also increased during allograft rejection in CB conditioned recipients given lymphodepletion. These observations suggest that allograft rejection following partial lymphocyte depletion is mediated by LIP of donor‐reactive memory T cells. As lymphopenia may cause unexpected rejection of stable allografts, adequate strategies must be developed to control T cell proliferation and differentiation during lymphopenia.
FinTech banking industry: a systemic approach

This paper aims to explore FinTech and its dynamic transitions in the banking industry. In particular, the study analyses the systemic innovation nature of FinTech-based innovations. The main contribution of this research study is the development of systemic innovation model which can be used as a dynamic tool to track the progress and pattern of technology development and diffusion. The research also discusses the latest financial innovation of PromptPay FinTech – the e-payment system in Thailand. ,This research uses the case study approach to analyse the systemic innovation characteristics of FinTech-based innovations. This research offers a new systemic innovation model which is developed and can be used as a dynamic tool to track the progress and pattern of technology development and diffusion. The study uses FinTech-based innovations as case study samples to gain a better understanding concerning the systemic characteristics and the pattern of technology diffusion under the analytical framework of systemic innovation model. This research involves qualitative interviews with five major commercial banks in the financial services industry of Thailand. ,The analyses of findings show the systemic characteristics of FinTech-based innovations in the banking industry, both at a global scale and Thailand case. The analyses have shown that systemic characteristics of the innovation process are the outcome of interactions between the complexity of the innovation and the capabilities of innovators in managing the innovation. The insightful implications on the systemic nature of innovation give the trend and direction of FinTech-based innovation development in the banking industry. ,The main contribution which shows originality and value of this paper is the development of systemic innovation model. This research study develops a systemic innovation model to analyse the systemic characteristics which can be applied to all innovations in any industry. The model can also help track the progress and pattern of technology development and diffusion. Therefore, the model can be used to project the trend and diffusion of innovation competition in the banking industry.
Cellular interactions in the vascular niche: implications in the regulation of tumor dormancy  

Angiogenesis plays an established role in the promotion of growth of dormant micrometastasis, because blood vessels deliver oxygen and nutrients to the tumor microenvironment. In addition to this feeding function, however, there is accumulating evidence suggesting that endothelial cells—and perhaps other cellular components of the microenvironment—could communicate both positive and negative signals to tumor cells. This cross‐talk between heterogeneous cell types could turn out to be important in the regulation of cancer cell behavior. Normal cells recruited during the angiogenic process, or attracted to future sites of metastasis by soluble products released by cancer cells, have been shown to create a niche favorable to tumor cell proliferation and survival. In addition, following an exogenous angiogenic spike, as may occur during inflammation, the same mechanisms could lead to re‐activation of poorly angiogenic tumor cells seeded into tissues. In this review, we discuss the possible implications of this hypothesis for our understanding of the phenomenon of tumor dormancy.
Validating the Effectiveness Indicators of Social Marketing Communication Campaigns for Reducing Health-Risk Behaviors Among Youth in Thailand

This study aims to validate the effectiveness indicators of social marketing communication campaigns for reducing health-risk behaviors among Thai youth by using a quantitative research with 1,000 undergraduate students aged 18-24 years old in Thailand. A second-order confirmatory factor analysis was used to check compliance with empirical data at the . 05 significance level. The findings showed that the effectiveness indicators of social marketing communication campaigns for reducing health-risk behaviors among Thai youth consist of forty-nine indicators from eight core components: 1) attitude toward health-risk behaviors reduction, 2) subjective norms, 3) perceived behavioral control, 4) intention to reduce health-risk behaviors, 5) practices for reducing health-risk behaviors, 6) knowledge in dangers and impacts of health-risk behaviors, 7) campaign brand equity, and 8) communication networks. These new developed effectiveness indicators should be taken into evaluating the effectiveness of social marketing communication campaigns for reducing health-risk behaviors among youtheffectively and efficiently for a sustained success both in Thailand and in international level.
Pancuronium increases the duration of electroencephalogram burst suppression in dogs anesthetized with isoflurane.

Earlier studies have demonstrated both a decrease as well as no effect on halothane MAC after administration of nondepolarizing neuromuscular relaxants. To clarify further the relationship between neuromuscular blocking agents and anesthetic potency, the authors studied the effect of pancuronium on steady-state electroencephalogram (EEG) burst suppression produced by isoflurane in dogs. Anesthesia was induced using isoflurane and oxygen via mask without the administration of other drugs. The trachea was intubated, and isoflurane was administered at a concentration sufficient to produce EEG burst suppression. Thereafter, end-tidal isoflurane concentration, temperature, and end-tidal PCO2 were meticulously maintained at constant values. Dogs in group 1 (n = 6) received pancuronium 0.1 mg.kg-1. The percent of the EEG that was isoelectric increased from 21 +/- 9% (mean +/- SD) to 35 +/- 11% (P less than 0.01). After the return of single-twitch response to train-of-four stimulation, neostigmine 0.05 mg.kg-1 and glycopyrrolate 0.01 mg.kg-1 were administered. This resulted in a reduction in EEG isoelectricity to 19 +/- 8% (P less than 0.01), similar to the value before pancuronium administration. In group 2 dogs (n = 6), the percent isoelectricity of the EEG prior to pancuronium was 25 +/- 10%. After administration of pancuronium 0.02, 0.04, and 0.2 mg.kg-1 sequentially, the percent isoelectricity of the EEG was 29 +/- 11, 37 +/- 15, and 43 +/- 9%, respectively. This represents a dose-related increase in isoelectricity for the 0.04- and 0.2-mg.kg-1 doses (P less than 0.05). (ABSTRACT TRUNCATED AT 250 WORDS)
S1 gene characteristics and efficacy of vaccination against infectious bronchitis virus field isolates from the United States and Israel (1996 to 2000)

The S1 genes of isolates of avian coronavirus infectious bronchitis virus (IBV) from commercial chickens in the US and Israel (20 isolates from each country) were studied using reverse transcription-polymerase chain reaction restriction fragment length polymorphism and sequencing. Partial sequences spanning the amino terminus region of S1 from amino acid residues 48 to 219, based on the Beaudette strain, were used for analysis. Phylogenetic clustering and high-sequence identity values were used to identify isolates that appeared to be derived from live IBV vaccines used in the two countries. Novel variant strains, unrelated by S1 sequencing and restriction fragment length polymorphism analyses to reference and vaccine strains, were also identified. Based on S1 sequence identity to available vaccines, the potential to use vaccination to control IBV infections was evaluated. Vaccination with commercial live strains Massachusetts (Mass), Arkansas (Ark) or DE/072/92, generally produced immunity against vaccine-related field isolates displaying high S1 sequence similarities (≥90%) to the respective vaccine strains. Immunization with a bivalent vaccine containing the Mass and Ark strains provided good cross-protection, averaging 81% against challenge with five variant isolates from the US having amino acid identity values ranging from 62 to 69% to Mass and from 68 to 83% to Ark, respectively. In contrast, the H120 vaccine strain induced low levels of protection, ranging from 25 to 58% against variant field isolates from Israel with amino acid identity values from 65 to 67%.
Development and validation of a prognostic model to predict the length of survival in patients with carcinomas of an unknown primary site.

PURPOSE To identify clinical and biologic variables with significant impact on survival in patients with carcinomas of an unknown primary site and to develop a simple prognostic model for the selection of patients in prospective clinical trials. PATIENTS AND METHODS Univariate and multivariate prognostic factor analyses were conducted in a population of 150 unselected patients and led to the construction of two successive classification schemes. An external data set of 116 patients enrolled onto two prospective trials was used for validation. RESULTS When studying clinical variables only, poor performance status (2 or 3) and presence of liver metastases were retained in the multivariate analysis. The first classification scheme consisted of three subgroups of patients with median survivals of 10.8, 6.0, and 2.4 months, according to the number of adverse prognostic factors. With the introduction of serum lactate dehydrogenase (LDH) levels in a further step, liver metastases were no longer significant. The second classification scheme therefore included poor performance status (relative risk [RR], 2.1) and elevated serum LDH level (RR, 2.1). Good-risk and poor-risk patients were identified, with median survivals of 11.7 months and 3.9 months, respectively (P <.0001). The 1-year survival rates were 45% and 11%, respectively. This second classification scheme was validated in an external data set: the median survival rates of patients assigned to the good-risk group and the poor-risk group were 12 months and 7 months, respectively (P =.0089). The 1-year survival rates were 53% and 23%, respectively. CONCLUSION A simple prognostic model using performance status and serum LDH levels was developed and validated. It allows the assignment of patients into two subgroups with divergent outcome. Further prospective trials will be designed using this prognostic model.
A Study on Impact of Optimum Workplace Culture Policy That Provides Work-Life Balance

Workplace culture is one word that talks about the unique characteristics and values of an organization. It reflects the individualities of an organization that is revealed through the attitude and personality of employees working in that group. The workplace culture has a direct link with the work-life balance of the employees. An excellent workplace culture should provide the employees lead a peaceful personal life and a successful professional life, thus helping to have a work life balance. But there might be challenges in implementing an excellent job place culture as the employees come from different social, cultural, economic and political background. This makes a tougher situation for the management to bring in appropriate policy for workplace culture, but once a suitable work-life culture system is implemented, it leads to the organizational commitment of the employees and increases their loyalty and dedication towards the organization. This article looks into the concerns of a group in framing a best-fit policy that suits all the employees and tries to see solutions as to how such an optimal policy could be structured and implemented that could make the organization as the most preferred place to work.
In-utero androgen exposure and 2nd to 4th digit length ratio-comparisons between healthy controls and females with classical congenital adrenal hyperplasia.

BACKGROUND Soft tissue measurements from the hand reveal lower second to fourth finger digit ratios (2D:4D) in males compared with females. The relatively longer 4th finger observed in males may be related to increased fetal exposure to androgens influencing the expression of Hox genes. METHODS We have measured 2D:4D ratios in 69 healthy females [median age 9.3 (range 1.9-17) years], 77 control males [median age 13.86 (2.1-20.3) years] and in 66 females with classical virilizing congenital adrenal hyperplasia (CAH) (median age 8.5 (1.1-16.2) years] who are known to be exposed to high concentrations of androgens in utero. Measurements were determined from X-rays of the left hand using vernier callipers. Intra-observer variability in measurement technique was 0.01%. RESULTS Control males had a significantly lower mean (SD) 2D:4D ratio [0.918 (0.029)] compared with female patients [0.927 (0.029), ANOVA P = 0.02]. No difference in 2D:4D ratio was observed between CAH females [0.925 (0.021)] and control females [0.927 (0.029)]. In contrast, 2D:4D ratio in males were significantly lower compared with CAH females (P = 0.03). CONCLUSIONS 2D:4D ratios determined directly from radiographs of the left hand confirm significant differences between males and females. However, female patients with virilizing CAH do not have a male digit ratio pattern suggesting that in the left hand digit ratio development is not influenced by in-utero exposure to androgens.
Smoking Modifies the Association Between Food Insecurity and Physical Performance

Few studies have examined the association between food insecurity and physical performance among older adults. To our knowledge, the effect modification of smoking status has never been examined in previous studies of food insecurity and physical performance. Using data from the 1999–2002 National Health and Nutrition Examination Survey (NHANES), we examined if the association between food insecurity and physical performance including gait speed and knee extensor power varied by smoking status among a nationally representative sample of men and women (≥50 y). Responses to the U.S. Household Food Security Survey Module (HFSSM) were used to assign participants to study categories. Multiple linear regression models controlling for age, gender, race/ethnicity, education, and income were used. The association between food insecurity and gait speed varied by smoking status (p = 0.005). For nonsmokers, those who were marginally food secure (0.91 m/s, p = 0.016) and food insecure (0.94 m/s, p = 0.004) had significantly slower gait speeds than food secure participants (1.04 m/s). Similar findings were found for knee extensor power. An association between food insecurity and either physical performance measures was not detected among smokers. Given the magnitude of the effects of smoking on physical performance, smoking appears to obscure the relationship between food insecurity and physical performance.
Psychological Well-being and Health Gains in the Developing World: Evidence from Peru and Malawi

Title of dissertation: PSYCHOLOGICAL WELL-BEING AND HEALTH GAINS IN THE DEVELOPING WORLD: EVIDENCE FROM PERU AND MALAWI Sarah W. Dickerson Dissertation directed by: Professor Carol Graham School of Public Policy In this dissertation, I assess the relationship between psychological well-being and health gains in Peru and Malawi. The first chapter consists of a comprehensive and systematic examination of research that frames the quantitative analyses found in the second and third chapters. It investigates literature on the relationship between maternal well-being and multiple dimensions of health in children and adolescents. It also explains how maternal depression may interact with poverty to worsen offspring’s outcomes. Then, it explores literature on the association between catastrophic health expenditure in Malawi and two of its potential predictors: unexplained happiness and access to antiretroviral therapy (ART), a treatment regimen for people living with HIV/AIDS. The second chapter assesses the impacts of maternal depression and life satisfaction on children in Peru. Using panel data from rounds three (2009-2010) and four (2013-2014) of Young Lives Peru, I find that children’s self-reported life satisfaction and health positively correlate with maternal life satisfaction and negatively associate with maternal depression. Furthermore, maternal life satisfaction predicts whether a female adolescent smokes, while maternal depression predicts smoking behavior and misinformation on pregnancy amongst male adolescents. The third chapter investigates the relationships between household catastrophic health expenditure in Malawi and two predictors, antiretroviral therapy (ART) and unexplained happiness. Using data from round two (2004-2005) and round three (2010-2011) of Malawi’s Integrated Household Survey, I find that proximity to ART-providing clinics and higher levels of psychological wellbeing associate with reduced likelihood of catastrophic health expenditure. PSYCHOLOGICAL WELL-BEING AND HEALTH GAINS IN THE DEVELOPING WORLD: EVIDENCE FROM PERU AND MALAWI
Building Australia's affordable housing industry: capacity challenges and capacity-enhancing strategies

ABSTRACT As in many other nations, Australia's intensifying shortage of affordable housing represents one of the most pressing policy challenges for government. Against a backdrop of ongoing population growth, the 20-year virtual moratorium on public housing construction means that, by 2016, the gross social housing provision deficit had reached 140,000 dwellings. And, while largely frozen in scale, the country's public housing system has also become increasingly residualised and rundown. In tackling these twin problems, some policy-makers and advocates have invested hopes in an emerging non-government affordable housing industry, largely configured around not-for-profit community housing providers. For some government players, however, the sector's nascent status and therefore ‘restricted capacity’ has been judged a crucial limitation on the extent to which it can be reasonably delegated responsibility for easing national housing stress. Applying a system-minded conception of the ‘affordable housing industry’ and adopting a multidimensional ‘capacity’ framework, this research investigated the factors limiting the scope for the industry's further expansion. In highlighting industry capacity restrictions stemming from the hollowing-out of government and its institutions, our findings connect with a wider policy studies literature and will have resonance in many countries beyond Australia – particularly in the Anglophone world.