Miracle-dz/UniFAR-FTUs huggingface dataset:
Epigenetic Regulation of microRNA Expression: Targeting the Triple-Negative Breast Cancer Phenotype

Abstract : The primary long-term objective of this research is to identify HDAC inhibitor (HDACi) regulated microRNAs which regulate the epithelial-to-mesenchymal transition (EMT) in triple-negative breast cancer (TNBC). Thus far we have assessed the microRNA expression profiles of two TNBC cell lines following treatment with HDACi identifying a number of up- and down-regulated microRNAs. The overall microRNA profile after HDACi treatment was indicative of a less aggressive phenotype. Treatment with HDACi also resulted in increased expression of E-cadherin as well as decreased migration of TNBC indicating a reversal of the EMT phenotype. These results, along with our ongoing research, suggest the ability of HDACi treatment to reverse the EMT phenotype, associated with metastatic and aggressive disease, of TNBC and support future evaluation of HDACi as therapeutic options for the clinical treatment of TNBC.
Analisis Gizi Limbah Ampas Kedelai Sebagai Tepung Subtitusi Mie untuk Menunjang Sumber Belajar Mata Kuliah Biokimia

Research this aim to know nutritional proximate analysis of okara noodle products that have the potential to add protein values and dietary fiber to noodles and whether this research can be used as a source of biochemistry learning resources. The initial stage of this research is the flouring okara followed by making wet noodle okara and analyze the nutritional content characterized by the high content of fiber and protein than wheat flour. The results showed that the nutritional value of wet noodles with okara flour substitution had 6.7 percent protein, ash 0.27 percent, water 66 percent, carbohydrate 26 percent, fat 0.5 percent, and fiber 2.4 percent. The content of okara noodle fiber is able to meet the sufficiency of fiber consumption recommended by United States Department of Agriculture (USDA) amount 25 to 30g for a day . Substitution of okara flour can significantly increase the value of protein and dietary fiber in wet noodles. Data of research result from nutrient analysis of okara noodles using proksimat method can also be used as supporting source of biochemistry course study Keywords : proximate test, noodles, waste, learning resources
Impact of Pharmacy-Led Education Regarding Multimodal Acute Pain Management on Medical Residents’ Prescribing of Opioids

Background: Opioids are commonly prescribed for patients with acute pain. Guidelines recommend multimodal regimens to synergistically treat pain and provide enhanced recovery. Objective: The objective of this study was to assess changes in oral morphine milligram equivalents (MMEs) prescribed by internal medicine (IM) medical residents for acute pain after a series of pharmacist-led in-services on prescribing multimodal pain regimens. Methods: Two hundred patients were assessed for changes in oral MMEs prescribed prior to and after a 3-part in-service series on multimodal pain management. Inclusion criteria included those who were admitted with acute pain managed by an IM resident, were prescribed analgesic(s), and were 18 years and older. Patients excluded were those admitted into the intensive care unit, receiving chronic pain management, obstetric patients, cancer patients, patients with previous opioid exposure, and patients using patient-controlled analgesia. The study outcomes were change in oral MMEs prescribed by medical residents for acute pain after the in-services, multimodal regimen use, appropriate analgesics prescribed, prescribing a bowel regimen if the patient was prescribed an opioid, and prescribers’ survey results. Results: A total of 6358.6 oral MMEs were prescribed before and 5297 oral MMEs were prescribed after the in-services. Fifty-eight patients before and 70 patients after the in-services were prescribed a multimodal regimen. Ten patients before and 18 patients after the in-services were given a bowel regimen. Eighty percent of the patients before and 85% after the in-services had an appropriate pain scale for their prescriptions. IM medical resident and student survey scores improved after each in-service. Conclusion: An educational series on multimodal regimens for acute pain management decreased opioid prescription and increased the use of multimodal regimens for acute pain.
A Graphic and Tactile Data Elicitation Tool for Qualitative Research: The Life Story Board

Data collection methods for qualitative research are varied and have a rich history. The Life Story Board (LSB) is a game board-like tool that is used to construct a visual representation of a person's narrative and his/her related context. In our study, we comparatively assessed the LSB as a data elicitation tool for social science research. We reviewed eight Canadian research projects that have used the LSB as data elicitation tool for qualitative research and assessed the LSB on the feasibility of its use, on its effectiveness to elicit information, on aspects that facilitate and/or hinder its use, and how it compares with conventional interview approaches. Our findings suggest that the LSB can be used with study participants of different gender, age, ethnicity, and life circumstances; that it is effective as a data elicitation tool, and that it facilitates engagement with interviewees, without presenting any major hindrances.
Standing Out and Sorting In: Exploring the Role of Racial Composition in Racial Disparities in Special Education

Schools differentially sort students into special education by race, though researchers debate the extent to which this is caused by racist school practices versus variation in student need due to other racial inequalities. I test the interaction between school-level racial composition and student-level race as a predictor of special education receipt. I find that as the proportion of White students increases, the risk of lower-status disabilities, such as intellectual disability, increases for Black, Latinx, and Native American students. As the proportion of White students decreases, White students’ risk of higher-status disabilities, such as speech/language impairment, increases relative to students of color. Thus, in the context of racial distinctiveness, student race becomes salient to sorting into special education.
Human Cadaver Burial Depth Affects Soil Microbial and Nutrient Status

Shallow burial (c. <0.3m) of human cadavers provides an alternative to standard burial depth (c. 1.0m) as this can enhance the natural recycling of nutrients to the soil through improved interactions between the corpse and the soil. However, there is a paucity of knowledge describing the interactions between the human cadaver and soil microbiology. The effects of shallow (pork) compared to standard burial depth (in a sandy loam and clay soil) identified that plant available nitrogen was consistently greater where the pork was shallow buried. There was also a shift in the soil’s bacterial community, but only in the sandy loam soil. Burial depth did not affect soil organic matter, available phosphorus, total microbial biomass or activity, or fungal biomass. The response of the bacterial community composition in the clay soils is likely due to reduced pore space and hence reduced oxygen at depth.
EVALUATION OF PANORAMIC RADIOGRAPHY MEASURES FOR IDENTIFYING REDUCED BONE MINERAL DENSITY IN ELDERLY

1 K›r›kkale Üniversitesi Diflhekimli¤i Fakültesi Oral Diagnoz ve Radyoloji Anabilim Dal› KIRIKKALE 2 K›r›kkale Üniversitesi Diflhekimli¤i Fakültesi Protetik Tedavi Anabilim Dal› KIRIKKALE 3 K›r›kkale Üniversitesi T›p Fakültesi Fizik Tedavi Anabilim Dal› KIRIKKALE Rana NALÇACI1 ‹lgi BARAN2 Sevim ORKUN3 Aliye TOSUN3 Melda MISIRLIO⁄LU1 EVALUATION OF PANORAMIC RADIOGRAPHY MEASURES FOR IDENTIFYING REDUCED BONE MINERAL DENSITY IN ELDERLY
DNA topoisomerase IIα and RAD21 cohesin complex component are predicted as potential therapeutic targets in bladder cancer

Cancer is essentially a genetic disease. Accumulated gene mutations accelerate genome instability, which eventually leads to uncontrollable growth of the tumor. Bladder cancer is the most common form of urinary tract cancer. This form of cancer has a poor prognosis due to its clinical heterogeneity and molecular diversity. Despite recent scientific advances, the knowledge and treatment of bladder cancer still lags behind that of other types of solid tumor. In the present study, available large data portals and other studies were used to obtain clinically relevant information, and the data were systematically processed to decipher the genes associated with bladder cancer. Genes associated with the survival time of patients with bladder cancer were successfully identified. The genes were enriched in common biological processes and pathways, and upregulated in tumor samples from patients. Among the top genes identified as associated with good or poor survival in bladder cancer, DNA topoisomerase IIα (TOP2α) and RAD21 cohesin complex component (RAD21) were also increased in bladder cancer tissues and cell lines. Therefore, TOP2α and RAD21 could be used as potential therapeutic targets in bladder cancer.
Cause Related Marketing and Customer Skepticism: A Study of Situational and Psychological Skepticism

Objective: The primary objective of the present study is to understand the antecedents to Skepticism towards brands involved in Cause Related Marketing and its outcomes. Methodology: To attain the above objective, quantitative research method was used to test the cleanliness of the measurement items using CFA and to test the conceptual model using SEM. Findings: It was found that two psychological variables, Utilitarianism and Hedonism, moderate the relationship between different Situational variables leading to Skepticism. Skepticism in turn was found to impact customer’s future Buying and Patronage Intention. The findings of the study would help academicians and marketers. Implications: Academicians will be enriched by the knowledge of various antecedents and moderating variables and their differential impacts on Skepticism. Marketers will be benefited as the insights will help them develop segment-wise positioning strategies for customer’s with different orientations for optimum benefits from CRM activities. Originality: The contribution of the present work is, studying the integrated impact of situational variables and pre-dispositional variables (due to one’s own psychology) on Skepticism and its impact on patronage intention. To the best of our knowledge, no such study is being undertaken so far.
Mdivi-1 Protects CD4+ T Cells against Apoptosis via Balancing Mitochondrial Fusion-Fission and Preventing the Induction of Endoplasmic Reticulum Stress in Sepsis

Apoptosis of CD4+ T cells plays a central role in the progression of sepsis because it is associated with subsequent immunosuppression and the lack of specific treatment. Thus, developing therapeutic strategies to attenuate the apoptosis of CD4+ T cells in sepsis is critical. Several studies have demonstrated that Mdivi-1, which is a selective inhibitor of the dynamin-related protein 1 (Drp1), attenuates apoptosis of myocardial cells and neurons during various pathologic states. The present study revealed the impact of Mdivi-1 on the apoptosis of CD4+ T cells in sepsis and the potential underlying mechanisms. We used lipopolysaccharide (LPS) stimulation and cecal ligation and puncture (CLP) surgery as sepsis models in vitro and in vivo, respectively. Our results showed that Mdivi-1 attenuated the apoptosis of CD4+ T cells both in vitro and in vivo. The potential mechanism underlying the protective effect of Mdivi-1 involved Mdivi-1 reestablishing mitochondrial fusion-fission balance in sepsis, as reflected by the expression of the mitofusin 2 (MFN2) and optic atrophy 1 (OPA1) , Drp1 translocation, and mitochondrial morphology, as observed by electron microscopy. Moreover, Mdivi-1 treatment reduced reactive oxygen species (ROS) production and prevented the induction of endoplasmic reticulum stress (ERS) and associated apoptosis. After using tunicamycin to activate ER stress, the protective effect of Mdivi-1 on CD4+ T cells was reversed. Our results suggested that Mdivi-1 ameliorated apoptosis in CD4+ T cells by reestablishing mitochondrial fusion-fission balance and preventing the induction of endoplasmic reticulum stress in experimental sepsis.
Outcomes of 23G vitrectomy and internal limiting membrane peeling with brilliant blue in patients with myopic foveoschisis from a retrospective cohort study

The aim of the present study was to investigate whether internal limiting membrane (ILM) peeling in patients with myopic foveoschisis (MF) treated with 23-gauge (23G) vitrectomy improved the anatomical and visual outcomes. In this retrospective cohort study, from March 2014 to August 2017 at the Department of Ophthalmology, The Second Affiliated Hospital of Nanchang University (Nanchang, China), 60 patients (60 eyes) with MF underwent 23G vitrectomy. The patients were grouped according to whether they underwent brilliant blue-assisted ILM peeling (peeling group) or not (non-peeling group). Best-corrected visual acuity (BCVA) and central macular thickness (CMT) on optical coherence tomography were measured. There were 30 eyes in each group and the baseline characteristics were similar (all P>0.05). BCVA improved in 24 eyes (80%) in the peeling group and 25 eyes (83.3%) in the non-peeling group (P=0.922). Preoperative CMT was not significantly different between the peeling and non-peeling group (458±62.2 vs. 460±61.1 µm, respectively, P=0.229). However, postoperative CMT was significantly different between the peeling and non-peeling group (269.3±67.7 vs. 294.4±60.5 µm, respectively; P=0.015). In the peeling group, MF was completely resolved in all 30 eyes, but only in 26 eyes in the non-peeling group (P=0.038). Postoperative Amsler testing was positive in five eyes in the peeling group and 13 eyes in the non-peeling group (P=0.024). Complications were similar in both groups; postoperatively, there were one and two cases of iatrogenic peripheral retinal break, three and two cases of macular hole, and one and one case of retinal detachment in the peeling and non-peeling groups, respectively.23G vitrectomy combined with brilliant blue-assisted ILM peeling resulted in better visual and anatomical effects compared with 23G vitrectomy alone in patients with MF.
Wall pressure and coherent structures in a turbulent boundary layer on a cylinder

Stephen R. Snarski and Richard M. Lueptow Journal of Fluid Mechanics / Volume 286 / March 1995, pp 137 ­ 171 DOI: 10.1017/S0022112095000681, Published online: 26 April 2006 Link to this article: http://journals.cambridge. org/abstract_S0022112095000681 How to cite this article: Stephen R. Snarski and Richard M. Lueptow (1995). Wall pressure and coherent structures in a turbulent boundary layer on a cylinder in axial flow. Journal of Fluid Mechanics, 286, pp 137­171 doi:10.1017/S0022112095000681 Request Permissions : Click here
The polyurethane/polyacrylate soap-free emulsion formation: effects of hydrophilic polyurethane

Abstract The vinyl group terminated water-borne polyurethanes (WPU) with different DMPA content were prepared. Subsequently the core-shell polyurethane/polyacrylate (PUA) composite emulsions were synthesized by soap-free emulsion copolymerization. The WPU as sole surfactant was used in copolymerization, and the lowest surface tension could be achieved to 38.8 mN m−1. Furthermore, the final conversion of acrylic monomer was reached to 98% in the case of WPU reactive seed. The FTIR-ATR indirectly confirmed the core-shell structure of PUA, simultaneously combined with DSC results found that the compatibility of WPU and PA was enhanced by growing grafting efficiency. The TEM results further indicated that the amount of DMPA in WPU had a great significant role in polymerization and final morphology structure. The PUA composite particles changed from scattered structure, core-shell structure to multi-core structure with increasing DMPA content. Correspondingly, the reinforcing and toughening effects were also found in PUA films with the increase content of DMPA by tensile testing.
Two‐Dimensional gcPIC Simulation of Rising‐Tone Chorus Waves in a Dipole Magnetic Field

Rising‐tone chorus waves have already been successfully produced in a mirror magnetic field with the use of one‐ and two‐dimensional particle‐in‐cell (PIC) simulations. However, in reality, the background magnetic field in the inner Earth's magnetosphere is a dipole magnetic field, unlike symmetric mirror fields. In this paper, with the two‐dimensional (2‐D) general curvilinear PIC (gcPIC) code, we investigate the generation of rising‐tone chorus waves in the dipole magnetic field configuration. The plasma consists of three components: immobile ions, cold background, and hot electrons. In order to save computational resource, the topology of the magnetic field is roughly equal to that at L = 0.6 RE, although the plasma parameters corresponding to those at L = 6 RE (RE is the Earth's radius) are used. Whistler mode waves are first excited around the magnetic equator by the hot electrons with a temperature anisotropy. The excited whistler mode waves propagate almost parallel and antiparallel to the background magnetic field in their source region, which is limited at ∣λ ∣ ≤ 3° (where λ is the magnetic latitude). When the waves leave from the source region and propagate toward high latitudes, both their amplitude and wave normal angle become larger. However, the group velocity of the waves is directed toward high latitudes almost along the magnetic field. During such a process, the waves have a frequency chirping, as shown by a rising tone in the frequency‐time spectrogram. To our best knowledge, it is for the first time that rising‐tone chorus are generated in a dipole magnetic field with a PIC simulation.
LOWER-LIMB DYNAMICS AND ENERGY ABSORPTION DURING THREE DIFFERENCE TYPES OF SINGLE LEG LANDINGS (9 - 16)

Journal of Sports Science and Physical Education 3(1): 9–16, 2015 - This research aimed to determine ACL injury risk from the jump landings by observing peak joint moments and energy absorptions. Single leg landings from 3 different jumps which were 1) drop jump (SDL) 2) counter movement jump (SCL), and 3) stop jump (SJL)) were investigated. Sixteen national hockey players of Australia participated in the study and performed all jump tasks, 5 trials each. Twelve high speed cameras, placed around the participants, captured 3D motion at 250 Hz and the force plate recorded the ground reaction at 2000 Hz synchronously. 3-D orientation of reflective markers attached on the athlete’s skin and the recorded ground reaction force were used for computation of moment and energy absorption of the lower limb. One way MANOVA with repeated measure was employed for statistical analysis. Results showed that the greatest peak knee valgus moment (p<0.001) was occurred during SJL. Hence, athletes are likely to get their ACL injured by performing the stop jump landing. In addition, SJL also led to the greatest peak hip abduction and internal rotation moments (p<0.01). The majority of energy absorption was occurred at the ankle joint (54-56%) while muscles around the knee (30% - 41%) and the hip (5-14%) joint contributed to a lesser energy absorption. Energy absorption implied that muscles contracted eccentrically. Since SJL induced the greatest amount of energy absorption at the ankle joint, then muscles around the ankle joint should be stronger in order to prevent injury from SJL. Keywords: Joint moment, energy absorptions, ACL.
Effect of plastic deformation rate at
room temperature on structure and
mechanical properties of high-Mn
austenitic Mn-Al-Si 25-3-3 type steel

Purpose: The aim of the paper is to determine influence of plastic deformation rate at room temperature on structure and mechanical properties of high-Mn austenitic Mn-Al-Si 25-3-3 type steel tested at room temperature. Design/methodology/approach: Mechanical properties of tested steel was determined using Zwick Z100 static testing machine for testing with the deformation speed equal 0.008 s-1, and RSO rotary hammer for testing with deformation speeds of 250, 500 and 1000s-1. The microstructure evolution samples tested in static and dynamic conditions was determined in metallographic investigations using light microscopy as well as X-ray diffraction. Findings: Based on X-ray phase analysis results, together with observation using metallographic microscope, it was concluded, that the investigated high-Mn X13MnAlSiNbTi25-3-3 steel demonstrates austenitic structure with numerous mechanical twins, what agrees with TWIP effect. It was demonstrated, that raise of plastic deformation rate produces higher tensile strength UTS and higher conventional yield point YS0.2. The UTS strength values for deformation rate 250, 500 and 1000 s-1 grew by: 35, 24 and 31%, appropriately, whereas in case of YS0.2 these were: 7, 74 and 130%, accordingly, in respect to the results for the investigated steel deformed under static conditions, where UTS and YS0.2 values are 1050 MPa and 700 MPa. Opposite tendency was observed for experimentally measured uniform and total relative elongation. Homogeneous austenitic structure was confirmed by X-ray diffractometer tests. Research limitations/implications: To fully describe influence of strain rates on structure and mechanical properties, further investigations specially with using transmission electron microscope are required. Practical implications: Knowledge about obtained microstructures and mechanical properties results of tested X13MnAlSiNbTi25-3-3 steel under static and dynamic conditions can be useful for the appropriate use of this type of engineering material in machines and equipment susceptible to static or dynamic loads. Originality/value: The influence of plastic deformation at room temperature under static and dynamic conditions of new-developed high-manganese austenitic X13MnAlSiNbTi25-3-3 steels were investigated.
Inflammation modulatory effect of perioperative high-dose statin in prevention of post-operative atrial fibrillation in patients undergoing coronary artery bypass grafting

Background: Atrial fibrillation (AF) is one of the most common complications after coronary artery bypass grafting (CABG), occurring in 20% to 40% of patients. Statins exert pleiotropic effects which are largely independent from their lipid-lowering properties. The objective of this study was based on to affirm the evidence that perioperative statins have a significant role in preventing early postoperative AF in patients undergoing CABG.Methods: A prospective, randomized, cohort study of all consecutive patients who underwent primary isolated on pump CABG surgery was performed. Patients were divided into two groups -statin and non-statin groups - to examine the influence of statins on early postoperative prevention of AF.Results: In total, 127 patients who underwent isolated CABG were included in the study and were analysed. There were no significant differences in age, gender, history of cardiac infarction, concomitant diseases (hypertension, smoking, PPCI, hyperlipidaemia), cardiac functional grading (NYHA III-IV), electro- cardiograms, and preoperative medication. There were no significant differences in the average number of grafts where the left internal mammary artery was used as a bypass conduit, the surgical procedure or total cardiopulmonary bypass time, or aortic cross-clamping (ACC) time. In addition, there were no significant differences in the postoperative mechanical ventilation duration time, length of ICU stays or length of hospitalization between the two groups. The incidence of AF following CABG in the statin group was significantly lower than that in the non-statin group.Conclusions: Oral atorvastatin 40 mg/d, initiated at least 1 week before the scheduled CABG and continued in the early postoperative period, significantly decreases the risk of post-operative AF.