Miracle-dz/UniFAR-FTUs huggingface dataset:
Attitudes to malaria, prevention, treatment and management strategies associated with the prevalence of malaria in a Nigerian urban center

This study investigates the basic factors responsible for human-mosquito interaction, attitudinal consequences of malaria treatment pattern and management strategies in an urban center. Questionnaires were issued to the volunteers whose age range between 15 and 40 years which constitute 44.5% males and 55.5% females. These include questions about knowledge of mosquito, prevention practices, treatment methods and illness management strategies. Focus group discussion was also used to interview the participants. Preventive measures adopted against mosquito bite include sleeping under net (treated and untreated) 17 (4.2%), door and window screening 37 (9.2%), cover cloth 55 (13.8%), mosquito repellant/insecticides spray 39 (9.8%), environmental hygiene 26 (6.5%), herbal decoction 26 (6.5%), and chemoprophylaxis 45 (11.3%). There was a significant difference between those that prevent malaria with chemoprophylaxis and other methods. Self treatment (medication) accounted for 267 (66.8%) as against hospital treatment 93 (23.3%). Most of the patients 55 (13.8%) demanded for injections as against 42 (10.5%) those who showed preference for oral medication. The hospitalized patients accounted for 40 (10.0%) while outpatients were 93 (23.3%). Late diagnosis, wrong medications, incomplete doses, lack of knowledge about malaria episode and anopheles mosquitoes as malaria vector are some of the factors militating against prevention and proper management of the illness.
Black Phosphorus Based Photocathodes in Wideband Bifacial Dye‐Sensitized Solar Cells

Ultrasmall black phosphorus quantum dots (BPQDs) serve as the near-infrared light absorber and charge transfer layer in the photocathode of a bifacial n-type dye sensitized solar cell. Wideband light absorption and ≈20% enhancement in the light-to-electron efficiency are accomplished due to the fast carrier transfer and complementary light absorption by the BPQDs demonstrating that BP has large potential in photovoltaics.
Revalidation of a modified and safe approach of stellate ganglion block

Stellate ganglion block (SGB) is very effective in management of chronic regional pain syndrome (CRPS-1). However, serious complication may occur due to accidental intravascular (intra-arterial) injection of local anaesthetic agents. Abdi and others, has suggested a modified technique in which fluoroscopy-guided block is given at the junction of uncinate process and body of vertebra at C7 level. In this approach vascular structures remain away from the trajectory of needle and thus avoid accidental vascular injection. We have used this technique of SGB in nine patients who were treated for CRPS-I. The blocks were effective in all the patients all the time without any vascular or other serious complication.
Prevalence and Risk Factors Associated With Low Back Pain Among Health Care Providers in a Kuwait Hospital

Study Design. A cross-sectional survey among health professionals working in a Kuwait hospital. Objective. To investigate the prevalence and factors associated with low back pain (LBP). Summary of Background Data. The literature suggests that health professionals are exposed to occupational risk factors that predispose them to developing LBP. These rates are not well established in Middle Eastern countries such as Kuwait. Methods. A self-administered survey was conducted with health professionals in an urban orthopedic hospital. Results. The response rate to the survey was 60% (n = 344). Lifetime prevalence of LBP in the sample was 70.9%, and point prevalence of LBP was 21.5%. Factors associated with acute LBP included direct patient contact (P = 0.015), performing patient lifts and/or transfers (P = 0.016), low job satisfaction (P = 0.039), and poor self-reported health status (P = 0.019). The prevalence ratio (PR) of reporting acute LBP was also found to increase as a function of the number of daily lifts/transfers performed (PR: 1.4; 95% CI: 1.27 to 1.70). Other factors generally associated with LBP, such as age, sex, professional experience, smoking and exercise, were not found to be significantly associated with LBP in this study. Conclusion. No causal relationships can be inferred using these cross-sectional data. However, results suggest that direct patient contact that includes lifting and/or transferring patients may be an important risk factor. Further research is warranted to evaluate effectiveness of back education and prevention programs among hospital staff in Kuwait.
Old‐onset Parkinson's disease compared with young‐onset disease: clinical differences and similarities

Of 261 patients with clinically diagnosed Parkinson's disease (PD), whose age at the onset was 58.2 ± 11.3, 46 patients with the onset age above 70 (the mean for the whole group + ISD) were compared to 44 patients with onset age below 47 (the mean for the whole group – ISD). Old‐onset PD patient were more susceptible to develop psychotic complications of levodopa treatment. More often had they tremor both as presenting and dominant symptom of their disease. Among young‐onset PD bradykinesia was more often the dominant clinical feature, and susceptibility to levodopa induced dyskinesia was higher. In 9 cases of young‐onset PD (20.5% of this group) paraesthesia was a presenting symptom, compared to only 1 patient (2%) in the group of old‐onset PD.
Satisfaction of Search in the Detection of Plain-Film Abnormalities in Abdominal Contrast Studies

RATIONALE AND OBJECTIVES.Satisfaction of search (SOS) occurs when a lesion is “missed” after detecting another lesion in the same radiograph. The authors investigated the SOS effect in abdominal contrast studies. METHODS.The authors measured detection of 23 plain film abnormalities in 43 patients who had plain film and contrast examinations. Each plain-film and contrast study was examined independently by 10 radiologists in two sessions, with receiver operating characteristic (ROC) curve areas estimated with the computer program RSCORE-J (University of Iowa, Iowa City, IA) for each condition. RESULTS.Observers more often missed plain film abnormalities present on contrast studies but also made fewer false-positive (FP) responses. There was no change in ROC area, but decision criteria grew more conservative. CONCLUSIONS.The reduction of detecting plain-film abnormalities in contrast examinations differs from the SOS effect of other imaging studies. The reduction in true-positive (TP) and false-positive (FP) rates suggests that a different cause may underlie these misses.
Randomised controlled trial of therapeutic assessment versus usual assessment in adolescents with self-harm: 2-year follow-up

Background An earlier randomised controlled trial demonstrated improved treatment engagement in adolescents who received Therapeutic Assessment (TA) versus Assessment As Usual (AAU), following an emergency presentation with self-harm. Objectives To determine 2-year outcomes for the same adolescents focusing on frequency of Accident and Emergency (A&E) self-harm presentations and treatment engagement. Method Patients in the TA groups (n=35) and the AAU group (n=34) were followed up 2 years after the initial assessment. Their primary and secondary care electronic records were analysed. Results There was no significant difference in the frequency of self-harm resulting in A&E presentations between the two groups (OR 0.69, 95% CI 0.23 to 2.13, p=0.53). Treatment engagement remained higher in the TA group than the AAU group. Conclusions TA is not associated with a lower frequency of A&E self-harm presentations. The effect of TA on engagement is maintained 2 years after the initial assessment. Interventions to reduce self-harm in adolescents are needed. Trial registration ISRCTN 81605131, http://www.controlled-trials.com/ISRCTN81605131/
Incidence of cronobacter sakazakii in powdered infant formula milk available in Malaysia

Enterobacter sakazakii previously known as ‘yellow-pigmented E. cloacae’ has been classified as a new genus ‘Cronobacter’ based on taxonomic analysis and geno-and phenotypic evaluation. This pathogenic organism has been associated with rare form of infant meningitis and necrotizing enterocolitis (NEC) with high mortality rate (40-80%). Some cases have been linked to the consumption of contaminated powdered infant formula milk (PIF). The objective of this study was to determine the presence of Cronobacter spp. in PIF sold in Malaysia. A selective chromogenic agar, Brilliance Enterobacter sakazakii (DFI, Oxoid), was used for detection of Cronobacter strains. Presumptive Cronobacter isolates were identified using biochemical tests (API 20E and Microgen TM ) and molecular assays (SYBR Green Real-time PCR and 16S ribosomal DNA sequencing). All presumptive Cronobacter strains produced typical blue-green colonies and non-Cronobacter strains produced yellow colonies on Brilliance Enterobacter sakazakii agar (DFI formulation). A total of 12 presumptive isolates were selected from DFI agar and identified with biochemical and molecular tests. The results indicated prevalence of 12.5% C. sakazakii contamination from 72 PIF samples. Molecular detection methods such as Real-time PCR and 16S rDNA proved to have higher identification percentage compared to the biochemical tests. In this study, it was observed that molecular assays were suitable means for sensitive identification of Cronobacter strains in PIF samples.
Impacts of Raw Data Temporal Resolution Using Selected Clustering Methods on Residential Electricity Load Profiles

There is growing interest in discerning behaviors of electricity users in both the residential and commercial sectors. With the advent of high-resolution time-series power demand data through advanced metering, mining this data could be costly from the computational viewpoint. One of the popular techniques is clustering, but depending on the algorithm the resolution of the data can have an important influence on the resulting clusters. This paper shows how temporal resolution of power demand profiles affects the quality of the clustering process, the consistency of cluster membership (profiles exhibiting similar behavior), and the efficiency of the clustering process. This work uses both raw data from household consumption data and synthetic profiles. The motivation for this work is to improve the clustering of electricity load profiles to help distinguish user types for tariff design and switching, fault and fraud detection, demand-side management, and energy efficiency measures. The key criterion for mining very large data sets is how little information needs to be used to get a reliable result, while maintaining privacy and security.
Blood Compatibility of a Newly Developed Trileaflet Mechanical Heart Valve

An ideal heart valve prosthesis, which has both the flow dynamic properties and blood compatibility of a tissue valve prosthesis and the durability of a mechanical prosthesis, does not exist. The Triflo trileaflet mechanical heart valve (MHV; Triflo Medical Inc., Irvine, CA) is a newly developed MHV prosthesis with the following design goals: central flow, minimal flow disturbance and stasis around the hinge region, and durability. The current study was conducted to evaluate the blood compatibility of a 29 mm Triflo MHV in the mitral position of eight calves for 5 months without any postoperative anticoagulation. Whole blood platelet aggregometry and the Xylum Clot Signature Analyzer (Xylum Corporation, Scarsdale, NY) were used to evaluate the postoperative changes in platelet and coagulation functions. Full autopsies, histological examinations of major internal organs, and scanning electron microscopy analyses of the explants were performed. Early termination occurred in two cases; one was because of valve thrombosis on the 25th day, and the other was killed because of a nonvalvular complication on the 105th day. The valve thrombosis was attributed to prolonged ventricular fibrillation at the time of valve replacement surgery. Whole blood platelet aggregometry and clot signature analyzer parameters did not show any sign of activation of platelets or the coagulation system. No hemolysis was observed. There was no macroscopic valve thrombosis or embolism observed in the remaining seven cases. Scanning electron microscopy analyses showed clean leaflet and valve ring surfaces, with only occasional minute platelet aggregations. Excellent blood compatibility of the Triflo MHV was demonstrated in this study.
Immune reconstitution inflammatory syndrome among HIV-infected South African infants initiating antiretroviral therapy

Objectives:To determine the incidence, clinical manifestations and risk factors for immune reconstitution inflammatory syndrome (IRIS) in young children initiating highly active antiretroviral therapy (HAART). Design:A prospective cohort of antiretroviral-naïve HIV-infected children less than 24 months of age enrolled in a treatment strategies trial in Johannesburg, South Africa. Methods:Among 169 HIV-infected children initiating HAART, April 2005 to November 2006, the records of 83 children suspected to have IRIS within 6 months of starting treatment were reviewed to determine whether they met criteria for IRIS. Seven were excluded due to incomplete follow-up. Pretreatment and post-treatment characteristics of children with and without IRIS were compared. Results:Overall, 34/162 (21%) children developed IRIS at a median of 16 days (range 7–115 days) post-HAART initiation. Bacille Calmette-Guérin reaction was most common occurring in 24/34 (71%) children, primarily injection site lesions and/or ipsilateral axillary lymphadenitis with abscess. Other IRIS conditions (not mutually exclusive) included Mycobacterium tuberculosis (n = 12), cytomegalovirus pneumonia (n = 1), Streptococcus pneumonia sepsis (n = 1), and severe seborrheic dermatitis (n = 1). Children with IRIS were younger (median age 7 vs. 10 months, P = 0.007) with a lower CD4 cell percentage (median 13.9 vs. 19.2, P = 0.009) at HAART initiation than controls. After 24 weeks on HAART, 62% of IRIS cases vs. 28% of controls had HIV RNA more than 400 copies/ml (P = 0.001), odds ratio = 2.88 (95% confidence interval = 1.14–7.29) after adjusting for baseline factors. Conclusion:Infants and young children with advanced HIV disease initiating HAART are at high risk for developing IRIS, leading to additional morbidity and possibly impairing virologic response to antiretroviral treatment.
Varicella-Zoster Virus Gene 66 Transcription and Translation in Latently Infected Human Ganglia

ABSTRACT Latent infection with varicella-zoster virus (VZV) is characterized by restricted virus gene expression and the absence of virus production. Of the ∼70 predicted VZV genes, only five (genes 4, 21, 29, 62, and 63) have been shown by multiple techniques to be transcribed during latency. IE62, the protein product of VZV gene 62, is the major immediate-early (IE) virus-encoded transactivator of viral gene transcription and plays a pivotal role in transactivating viral genes during lytic infection. The protein kinase (66-pk) encoded by VZV gene 66 phosphorylates IE62, resulting in cytoplasmic accumulation of IE62 that mitigates nuclear IE62-induced gene activation. Analysis of latently infected human trigeminal ganglia for 66-pk expression by reverse transcriptase-dependent nested PCR, including DNA sequence analysis, in situ hybridization, and immunohistochemistry, revealed VZV open reading frame 66 to be a previously unrecognized latently expressed virus gene and suggests that prevention of IE62 import to the nucleus by VZV 66-pk phosphorylation is one possible mechanism by which VZV latency is maintained.
The Institutional Context of an 'Empirical Law': The Wage Curve Under Different Regimes of Collective Bargaining

The wage curve identified by Blanchflower and Oswald (1994) postulates that the wage level is a decreasing function of the regional unemployment rate. In testing this hypothesis, most empirical studies have not taken into account that differences in the institutional framework may have an impact on the existence (or the slope) of a wage curve. Using a large-scale linked employer-employee data set for western Germany, this paper provides a first test of the relevance of different bargaining regimes and of works councils for the existence of a wage curve. In pooled regressions for the period 1998 to 2006 as well as in worker-level or plant-level fixed-effects estimations we obtain evidence for a wage curve for plants with a collective bargaining agreement at firm level. The point estimates for this group of plants are close to the -0.1 elasticity of wages with respect to unemployment postulated by Blanchflower and Oswald. In this regime, we also find that works councils dampen the adjustment of wages to the regional unemployment situation. In the other regimes of plants that either do not make use of collective contracts or apply sectoral agreements, we do not find a wage curve.
Stimulated Biodegradation of Spent Lubricating Motor oil in Soil Amended with Animal droppings.

The potentials of organic wastes from animal droppings as bioremediation alternative for soils spiked with waste-lubricating motor oil (spent oil) was evaluated. The rate of biodegradation of the spent oil was studied for a period of 6 months under laboratory condition. The result of the microbial counts for soils spiked with 5000 mgkg- 1 (0.5%) spent oil has its total heterotrophic bacterial count in unamended control soil ranging from 2.71±0.09 to 7.21±0.25 x 10 6 CFU/g of soil, while those of soil amended with cow droppings (CD) ranged from 16.0±1.01 to 47.90±0.36x 10 6 CFU/g of soil and those of soil amended with goat droppings (GD) and poultry manure(PM) ranged from 16.6±0.6 to 57.9±0.15 x 10 6 and 18.00±0.20×10 6 to 60.80± 1.19 ×10 6 CFU/g of soil respectively. The counts of hydrocarbon-utilizing bacteria (HUB) in unamended control soil ranged from 0.93±0.11 to 2.10±0.15 ×10 6 CFU/g of soil. The count of HUB in PM amended soil was significantly higher than those amended with goat droppings (GD), while those of goat dropping were higher than those of cow dung. The HUB count in GD amended soil ranged from 8.07±0.12x10 6 to 67.70±0.68 x 10 6 cfu/g of soil. The THB and HUB counts for soils spiked with 25000 mg/kg (2.5%) spent oil exhibited a similar trend as was observed for soil spiked with 0.5% spent oil. Evaluation by the first-order kinetic model which utilized combined data for the entire period revealed that PM with biodegradation rate constant of 0.2332 day- 1 and half-life of 2.97days was better in stimulating biodegradation of oil at higher concentration, while GD with a biodegradation constant of 0.3253day- 1 and half-life of 2.13 days performed better at low pollution when compared to that of PM and CD. Keywords : Biodegradation, waste-lubricating oil, Bacteria, Organic waste, Hydrocarbon.
Effects of Electrical Stimulation on Risk Factors for Developing Pressure Ulcers in People with a Spinal Cord Injury: A Focused Review of Literature

ABSTRACTPressure ulcers (PUs) are a common and serious problem for wheelchair users, such as individuals with a spinal cord injury (SCI), resulting in great discomfort, loss of quality of life, and significant medical care costs. Therefore, it is of utmost importance to prevent PUs. In this literature overview, the effects of electrical stimulation (ES) on the risk factors for developing PUs in people with an SCI are examined and synthesized from January 1980 to January 2015. Thirty-four relevant studies of PU prevention in SCI were identified. Four were randomized clinical trials, 24 were case series, 6 had other designs. Three types of ES modalities were identified. The methodological quality varied from poor to fairly strong, with a large variety in used ES parameters. Twenty-three studies were identified describing short-term effects of ES on interface pressure, oxygenation, and/or blood flow, and 24 studies described the long-term effects of ES on muscle volume, muscle strength, and histology. Whereas there is a lack of controlled studies on the effects of ES on PU incidence, which disallows definite conclusions, there is moderate evidence to suggest that ES-induced muscle activation has a positive influence on several risk factors for developing PUs in people with an SCI.
Sildenafil (Viagra) and Club Drug Use in Gay and Bisexual Men: The Role of Drug Combinations and Context

Data ascertained in a study of club drug use among 450 gay and bisexual men indicate that at least one class of PDE-5 (phosphodiesterase type 5 inhibitor, sildenafil [Viagra]) is used frequently in combination with club drugs such as methamphetamine, MDMA (3,4 methylenedioxymethamphetamine [ecstasy]), ketamine, cocaine, and GHB (gamma hydroxy butyrate). Patterns of sildenafil use in combination with each of the club drugs differ among key demographics including race and age. Multivariate models, controlling for demographic factors, suggest that contextual factors are key to understanding why men mix sildenafil with club drugs, although age may still be an important issue to consider. Of particular importance is the fact that use of club drugs in combination with sildenafil is strongly associated with circuit and sex parties, where a centerpiece of these environments focuses on sexual exchange. These models imply interplay between person-level and contextual factors in explaining drug use patterns and further indicate that interventions aimed at addressing illicit substance use must carefully consider the role of environmental factors in explaining behavior.
Screening for drug-induced hepatotoxicity in primary mouse hepatocytes using acetaminophen, amiodarone, and cyclosporin a as model compounds: an omics-guided approach.

Drug-induced hepatotoxicity is a leading cause of attrition for candidate pharmaceuticals in development. New preclinical screening methods are crucial to predict drug toxicity prior to human studies. Of all in vitro hepatotoxicity models, primary human hepatocytes are considered as 'the gold standard. ' However, their use is hindered by limited availability and inter-individual variation. These barriers may be overcome by using primary mouse hepatocytes. We used differential in gel electrophoresis (DIGE) to study large-scale protein expression of primary mouse hepatocytes. These hepatocytes were exposed to three well-defined hepatotoxicants: acetaminophen, amiodarone, and cyclosporin A. Each hepatotoxicant induces a different hepatotoxic phenotype. Based on the DIGE results, the mRNA expression levels of deregulated proteins from cyclosporin A-treated cells were also analyzed. We were able to distinguish cyclosporin A from controls, as well as acetaminophen and amiodarone-treated samples. Cyclosporin A induced endoplasmic reticulum (ER) stress and altered the ER-Golgi transport. Moreover, liver carboxylesterase and bile salt sulfotransferase were differentially expressed. These proteins were associated with a protective adaptive response against cyclosporin A-induced cholestasis. The results of this study are comparable with effects in HepG2 cells. Therefore, we suggest both models can be used to analyze the cholestatic properties of cyclosporin A. Furthermore, this study showed a conserved response between primary mouse hepatocytes and HepG2 cells. These findings collectively lend support for use of omics strategies in preclinical toxicology, and might inform future efforts to better link preclinical and clinical research in rational drug development.