Miracle-dz/UniFAR-FTUs huggingface dataset:
Calculation of cable thermal rating considering non-isothermal earth surface

The study presents an algorithm to compute the heat transfer coefficient for thermal cable rating when modelling the non-isothermal earth surface with the additional wall method. The position of the fictitious images is computed analytically by recognising that the complex geometrical arrangement can be converted into a much simpler one using the Fourier transform. This allows for the estimation of the heat transfer coefficient with simple formulas. The resulting equations are very easy to implement and are entirely compatible with the standardised methods (IEC and IEEE) for rating power cables. Hundreds of finite elements simulations have been performed to validate the proposed method which yielded results with typical differences of <5% for standard installations.
The Predicted G-Protein-Coupled Receptor GPR-1 Is Required for Female Sexual Development in the Multicellular Fungus Neurospora crassa

ABSTRACT G-protein-coupled receptors (GPCRs) control important aspects of asexual and sexual development in eukaryotic organisms. We have identified a predicted GPCR in the filamentous fungus Neurospora crassa with similarity to cyclic AMP-receptor like GPCRs from Dictyostelium discoideum and GCR1 from Arabidopsis thaliana. Expression of gpr-1 is highest in female reproductive structures, and deletion of gpr-1 leads to defects during sexual development. Unfertilized female structures (protoperithecia) fromΔ gpr-1 strains are weakly pigmented, small, and submerged in the agar. The perithecia produced after fertilization have deformed beaks that lack ostioles, the openings through which ascospores are discharged. Localization studies using a GPR-1-green fluorescent protein fusion protein showed that GPR-1 is targeted to female reproductive structures. Genetic epistasis experiments with the three Gα genes were inconclusive due to the early block in mating exhibited by Δgna-1 strains. Phenotypic analysis of mutants from a high-throughput N. crassa knockout project allowed identification of BEK-1, a homeodomain transcription factor that is a potential target of GPR-1. The perithecial defects ofΔ bek-1 strains are similar to those of theΔ gpr-1 strain, and epistasis analysis indicates that bek-1 could function downstream of gpr-1 during postfertilization events. The effect must be posttranscriptional, as bek-1 transcript levels are not affected inΔ gpr-1 strains. The lack of ostioles inΔ gpr-1 and Δbek-1 mutants has an undesirable effect on the ability to spread progeny (ascospores) by the normal ejection mechanism and would severely compromise the fitness of these strains in nature.
Can Anchor Models Explain Inverted-U Effects in Facial Judgments?

Researchers in a variety of disciplines have found that participants take less time and generate less diversity of responses when judging stimuli towards the ends of a scale than when judging those near the center. Three types of models, connectionist, exemplar, and anchor models, can account for these inverted-U effects. Anchor models assume that stimuli near the ends of the scale are used as anchors to compare with the other stimuli, implying that anchor representations are activated for each judgment. Therefore, participants should learn the anchors better than the other stimuli. Participants were 40 students from the Department of Psychology at McGill University (5 men; M age = 20.5 yr.; SD = 1.7). The experiment involved two tasks: first participants judged facial gender and then performed a recognition task. The results showed no correlation between the position on the gender scale and recognition accuracy. Several hypotheses were offered to explain these results.
Two members of the TRPP family of ion channels, Pkd1l3 and Pkd2l1, are co‐expressed in a subset of taste receptor cells

Taste receptors cells are responsible for detecting a wide variety of chemical stimuli. Several molecules including both G protein coupled receptors and ion channels have been shown to be involved in the detection and transduction of tastants. We report on the expression of two members of the transient receptor potential (TRP) family of ion channels, PKD1L3 and PKD2L1, in taste receptor cells. Both of these channels belong to the larger polycystic kidney disease (PKD or TRPP) subfamily of TRP channels, members of which have been demonstrated to be non‐selective cation channels and permeable to both Na+ and Ca2+. Pkd1l3 and Pkd2l1 are co‐expressed in a select subset of taste receptor cells and therefore may, like other PKD channels, function as a heteromer. We found the taste receptor cells expressing Pkd1l3 and Pkd2l1 to be distinct from those that express components of sweet, bitter and umami signal transduction pathways. These results provide the first evidence for a role of TRPP channels in taste receptor cell function.
Pareto Equilibria with coherent measures of risk

In this paper, we provide a definition of Pareto equilibrium in terms of risk measures, and present necessary and sufficient conditions for equilibrium in a market with finitely many traders (whom we call “banks”) who trade with each other in a financial market. Each bank has a preference relation on random payoffs which is monotonic, complete, transitive, convex, and continuous; we show that this, together with the current position of the bank, leads to a family of valuation measures for the bank. We show that a market is in Pareto equilibrium if and only if there exists a (possibly signed) measure that, for each bank, agrees with a positive convex combination of all valuation measures used by that bank on securities traded by that bank.
Morphological and electrophysiological characteristics of layer V neurons of the rat medial entorhinal cortex

This study aimed to characterize the morphological and electrophysiological properties of neurons in layer V of the entorhinal cortex in the rat brain. Using the in vitro slice preparation and sharp electrode techniques, we recorded from layer V neurons located in the medial entorhinal cortex. Recorded cells were also labeled with biocytin. Based on morphological criteria, layer V of the entorhinal cortex is comprised of three categories of neurons: pyramidal cells, horizontal cells, and polymorphic cells. Horizontal cells could be easily distinguished from the pyramidal cells because the bulk of their dendritic plexus extended horizontally within layer V. Polymorphic cells vary in size and shape. Interestingly, they typically do not have apical dendrites, and some of them have dendrites that extend into the subiculum. Based on electrophysiological criteria alone, it was not possible to unequivocally distinguish the morphological cell types because they were somewhat heterogeneous with respect to several parameters including inward rectification, spike‐frequency adaptation, and intrinsic oscillations. Nevertheless, although most horizontal cells displayed time‐dependent inward rectification, most pyramidal cells displayed fast inward rectification exclusively. None of the entorhinal cortex layer V cells displayed oscillatory activity like that of neocortical layer V “bursting” cells, although neurons from all groups displayed rhythmic subthreshold membrane potential oscillations. In summary, we have found that layer V of the rat medial entorhinal cortex consists of three morphologically distinct neuronal subtypes that cannot be clearly distinguished from each other by traditional electrophysiological measures. J. Comp. Neurol. 418:457–472, 2000. © 2000 Wiley‐Liss, Inc.
SOCIAL-EMOTIONAL AND CHARACTER DEVELOPMENT SCALE Development and Initial Validation With Urban Elementary School Students

The Social-Emotional and Character Development Scale (SECDS) is intended as a measnre of social-emotional skills and character for elementary school-age children. This study investigated the mea­ sure's psychometric properties using data collected over 5 waves for a cohort of students followed from Grades 3 to 5 in 14 nrban elementary schools (NRange ~ 500 to 593). Confirmatory factor analysis indicated good fit to the measnre' s hypothesized first- and second-order factor structure at each wave. Scales corre­ sponding to the first-order factor structure demonstrated adequate internal consistency and test-retest reliabil­ ity. Consistent with previous research using similar measnres of social-emotional skills and character, a longitudinal analysis indicated that the means for these scales decreased over the 5 waves. The validity of the SECDS general and individual scales was supported via their patterns of association with measnres of expected correlates of social-emotional skills and character. Overall, findings suggest the SECDS is appropri­ ate for assessing the development of different facets of social-emotional skills and character dnring elemen­ tary grades and that it could be useful for investigating their role in the developmental pathways for a range of important youth outcomes.
Inhibition of MEK or cdc2 kinase parthenogenetically activates mouse eggs and yields the same phenotypes as Mos(-/-) parthenogenotes.

Mammalian eggs are arrested in metaphase II of meiosis until fertilization. Arrest is maintained by cytostatic factor (CSF) activity, which is dependent on the MOS-MEK-MAPK pathway. Inhibition of MEK1/2 with a specific inhibitor, U0126, parthenogenetically activated mouse eggs, producing phenotypes similar to Mos(-/-) parthenogenotes (premature, unequal cleavages and large polar bodies). U0126 inactivated MAPK in eggs within 1 h, in contrast to the 5 h required after fertilization, while the time course of MPF inactivation was similar in U0126-activated and fertilized eggs. We also found that inactivation of MPF by the cdc2 kinase inhibitor roscovitine induced parthenogenetic activation. Inactivation of MPF by roscovitine resulted in the subsequent inactivation of MAPK with a time course similar to that following fertilization. Notably, roscovitine also produced some Mos(-/-)-like phenotypes, indistinguishable from U0126 parthenogenotes. Simultaneous inhibition of both MPF and MAPK in eggs treated with roscovitine and U0126 produced a very high proportion of eggs with the more severe phenotype. These findings confirm that MEK is a required component of CSF in mammalian eggs and imply that the sequential inactivation of MPF followed by MAPK inactivation is required for normal spindle function and polar body emission.
Liposomal doxorubicin in combination with bortezomib for relapsed or refractory multiple myeloma.

PURPOSE On May 17, 2007, doxorubicin HCl liposome injection (Doxil) in combination with bortezomib (Velcade) received approval from the US Food and Drug Administration (FDA) for the treatment of relapsed or refractory multiple myeloma after at least one prior therapy that has not included bortezomib. Liposomal doxorubicin's efficacy and safety were demonstrated in a phase III, randomized, multicenter, international trial comparing the combination of this agent plus bortezomib vs bortezomib alone in multiple myeloma patients who had not previously received bortezomib and had received at least one prior therapy. Here we summarize the FDA review of the data that support this approval. EXPERIMENTAL DESIGN AND RESULTS An interim analysis of time to disease progression (TTP), the primary endpoint, was conducted after 249 TTP events in this study that randomized 324 patients to liposomal doxorubicin plus bortezomib treatment and 322 patients to bortezomib monotherapy. Time to progression was significantly prolonged in the combination arm (median TTP = 9.3 months) compared with bortezomib monotherapy (median TTP = 6.5 months), P < . 0001 (log-rank test); hazard ratio = 0.55 (95% confidence interval = 0.43-0.71). The response rates were similar between the two arms and not statistically different; however, among responding patients, the median duration of response was longer with the combination--10.2 months compared to 7.0 months in the monotherapy arm. Adverse reactions occurred more frequently with the combination therapy. As compared to the monotherapy, frequent grade 3/4 adverse reactions with the combination were neutropenia and thrombocytopenia. CONCLUSIONS Liposomal doxorubicin received FDA approval for use in combination with bortezomib in patients with multiple myeloma who have not previously received bortezomib and have received at least one prior therapy.
Attention Networks for Weakly Supervised Object Localization Eu

We consider the problem of weakly supervised learning for object localization. Given a collection of images with image-level annotations indicating the presence/absence of an object, our goal is to localize the object in each image. We propose a neural network architecture called the attention network for this problem. Given a set of candidate regions in an image, the attention network first computes an attention score on each candidate region in the image. Then these candidate regions are combined together with their attention scores to form a whole-image feature vector. This feature vector is used for classifying the image. The object localization is implicitly achieved via the attention scores on candidate regions. We demonstrate that our approach achieves superior performance on several benchmark datasets.
Normality and the Psychiatrist*

The terms “normal” and “normality” are sometimes used with a sense of authority that defies the questioning of their validity. This paper reviews different parameters of “normality” and points out difficulties in its conceptualisation. The implications of the designation of deviation from normality are then discussed. In concluding, the acceptance of a wide range of “normality” is stressed.
Using Doppler radar with a simple explicit microphysics model to diagnose problems with ice sublimation depth‐scales in forecast models

Several previous studies have attempted to assess the sublimation depth‐scales of ice particles from clouds into clear air. Upon examining the sublimation depth‐scales in the Met Office Unified Model (MetUM), it was found that the MetUM has evaporation depth‐scales 2–3 times larger than radar observations. Similar results can be seen in the European Centre for Medium‐Range Weather Forecasts (ECMWF), Regional Atmospheric Climate Model (RACMO) and Météo‐France models. In this study, we use radar simulation (converting model variables into radar observations) and one‐dimensional explicit microphysics numerical modelling to test and diagnose the cause of the deep sublimation depth‐scales in the forecast model. The MetUM data and parametrization scheme are used to predict terminal velocity, which can be compared with the observed Doppler velocity. This can then be used to test the hypothesis as to why the sublimation depth‐scale is too large within the MetUM. Turbulence could lead to dry air entrainment and higher evaporation rates; particle density may be wrong, particle capacitance may be too high and lead to incorrect evaporation rates or the humidity within the sublimating layer may be incorrectly represented. We show that the most likely cause of deep sublimation zones is an incorrect representation of model humidity in the layer. This is tested further by using a one‐dimensional explicit microphysics model, which tests the sensitivity of ice sublimation to key atmospheric variables and is capable of including sonde and radar measurements to simulate real cases. Results suggest that the MetUM grid resolution at ice cloud altitudes is not sufficient enough to maintain the sharp drop in humidity that is observed in the sublimation zone. Copyright © 2010 Royal Meteorological Society and Crown Copyright.
Role of ST2 in non-ST-elevation acute coronary syndrome in the MERLIN-TIMI 36 trial.

OBJECTIVE We investigated the prognostic performance of ST2 with respect to cardiovascular death (CVD) and heart failure (HF) in patients with non-ST-elevation acute coronary syndrome (NSTE-ACS) in a large multinational trial. BACKGROUND Myocytes that are subjected to mechanical stress secrete ST2, a soluble interleukin-1 receptor family member that is associated with HF after STE-ACS. METHODS We measured ST2 with a high-sensitivity assay in all available baseline samples (N=4426) in patients enrolled in the Metabolic Efficiency With Ranolazine for Less Ischemia in the Non-ST-Elevation Acute Coronary Syndrome Thrombolysis in Myocardial Infarction 36 (MERLIN-TIMI 36), a placebo-controlled trial of ranolazine in NSTE-ACS. All events, including cardiovascular death and new or worsening HF, were adjudicated by an independent events committee. RESULTS Patients with ST2 concentrations in the top quartile (>35 μg/L) were more likely to be older and male and have diabetes and renal dysfunction. ST2 was only weakly correlated with troponin and B-type natriuretic peptide. High ST2 was associated with increased risk for CVD/HF at 30 days (6.6% vs 1.6%, P<0.0001) and 1 year (12.2% vs 5.2%, P<0.0001). The risk associated with ST2 was significant after adjustment for clinical covariates and biomarkers (adjusted hazard ratio CVD/HF 1.90, 95% CI 1.15-3.13 at 30 days, P=0.012; 1.51, 95% CI 1.15-1.98 at 1 year, P=0.003), with a significant integrated discrimination improvement (P<0.0001). No significant interaction was found between ST2 and ranolazine (Pinteraction=0.15). CONCLUSIONS ST2 correlates weakly with biomarkers of acute injury and hemodynamic stress but is strongly associated with the risk of HF after NSTE-ACS. This biomarker and related pathway merit further investigation as potential therapeutic targets for patients with ACS at risk for cardiac remodeling.
Awareness of Sexually Transmitted Diseases among Adolescents in Saudi Arabia

The aim of the study, due to the worldwide prevalent increase of sexually transmitted diseases, was to investigate the local adolescents' awareness of sexually transmitted diseases, including their level of knowledge regarding the mode of transmission and prevention of sexually transmitted diseases. The study was performed using a standard questionnaire which was distributed to the general public eliciting information about the knowledge of sexually transmitted diseases. 536 participants were randomly selected amongst medical and non-medical youth aged 18-25. Despite tremendous efforts, 49 participants did not answer some of the addressed questions, so they were excluded from the study. The study showed that the local population of Jeddah lacked awareness of sexually transmitted diseases, and they have incorrect perceptions. Most common sources from which information was obtained were primarily mass media rather than school education. 274(56%) wanted to know if they had any kind of sexually transmitted diseases. Only 257 participants (53%) thought that Human Papilloma Virus was a sexually transmitted disease. 340 participants (70%) thought that Herpes Simplex Virus was a sexually transmitted diseases. 282 participants (58%) thought that Chlamydia was a sexually transmitted disease. Sexually transmitted diseases are common and preventable causes of morbidity and serious complications; thus primary prevention of sexually transmitted diseases needs to be given high priority. Education about sexually transmitted diseases should be addressed early on in schools to encourage premarital screenings and hence help reduce the risk of the possible expansion of infection in the Kingdom .
Predicting Knowledge Sharing Intention Based on Theory of Reasoned Action Framework: An Empirical Study on Higher Education Institution

Based on theory of reasoned action (TRA) theoretical framework, this study try to predict individual knowledge sharing intention on higher education institution context. This study also integrate some potential factors (channel richness, psychological forces and organizational climate factors) which supporting individuals' knowledge-sharing intentions Through a field survey of 242 lecturer on public and privateuniversity at Purwokerto and Yogyakarta city, this study confirm our hypothesis that attitudes toward knowledge sharing and subjective norms with regard to knowledge sharing as well as organizational climate affect individuals' intentions to share knowledge. This study showed thatPerceived Reciprocal Benefits, Perceived Enjoyment in Helping Others, Perceived Reputation Enhancement and channel richness affect individuals'attitudes toward knowledge sharing while organizational climate affect subjective norms. Overall, the results of the study advance prior research in the area of knowledge sharing by shedding light on the determinants of knowledge sharing behaviors of knowledge workers. These insights could be used by university in developing work environments that are conducive for knowledge worker to share their knowledge. Keyword: Knowledge sharing intention, TRA, Knowledge worker, attitude, university.
Chaos-based modeling of DC arc furnaces for power quality issues

DC arc furnaces are more and more applied in large industrial systems and represent one of the major sources of perturbations for the feeding system. This paper deals with the problem of the dc arc modeling using three well-known chaotic attractors (Ro/spl uml/ssler, Chua, and Lorenz attractors). A new tuning procedure is adopted to determine the most adequate parameters of the attractors to model the dc arc furnace. Waveform distortions and voltage fluctuations indexes are calculated from the simulation results of a whole existing plant and compared with measured data. The proposed models of dc arc furnace can be used to assess the impact in terms of power quality of the dc arc furnace when planning new plants or evaluating the performances of compensating devices.
Attacks on Anonymization-Based Privacy-Preserving: A Survey for Data Mining and Data Publishing

Data mining is the extraction of vast interesting patterns or knowledge from huge amount of data. The initial idea of privacy-preserving data mining PPDM was to extend traditional data mining techniques to work with the data modified to mask sensitive information. The key issues were how to modify the data and how to recover the data mining result from the modified data. Privacy-preserving data mining considers the problem of running data mining algorithms on confidential data that is not supposed to be revealed even to the party running the algorithm. In contrast, privacy-preserving data publishing (PPDP) may not necessarily be tied to a specific data mining task, and the data mining task may be unknown at the time of data publishing. PPDP studies how to transform raw data into a version that is immunized against privacy attacks but that still supports effective data mining tasks. Privacy-preserving for both data mining (PPDM) and data publishing (PPDP) has become increasingly popular because it allows sharing of privacy sensitive data for analysis purposes. One well studied approach is the k-anonymity model [1] which in turn led to other models such as confidence bounding, l-diversity, t-closeness, (α,k)-anonymity, etc. In particular, all known mechanisms try to minimize information loss and such an attempt provides a loophole for attacks. The aim of this paper is to present a survey for most of the common attacks techniques for anonymization-based PPDM & PPDP and explain their effects on Data Privacy.