Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparison of Olanzapine versus Other Second-Generation Antipsychotics in the Improvement of Insight and Medication Discontinuation Rate in Schizophrenia

Background In the last decade, olanzapine became widely used in mental health service worldwide even after being criticized for its metabolic side effects. Patients with schizophrenia on olanzapine were usually found to stay on their medications longer than the other second-generation antipsychotics (SGAs) except clozapine. The reason for this is unknown. Objective This prospective study compared the influences of olanzapine and other SGAs except clozapine on improving insight and medication discontinuation rate in schizophrenia. Methods A total of 148 patients with schizophrenia medically indicated for initiation of treatment with olanzapine or other SGAs were evaluated for symptoms, insight, attitudes toward medication, side effects, body weight and fasting lipid and glucose parameters at admission and before discharge, and follow-up calls one-year after discharge documented whether they were regularly taking prescribed psychotropic medication or not. Results After an average of 72.8 days of inpatient treatment, the olanzapine and other SGAs group exhibited similar levels of symptom improvement with an average reduction of 28.7 in the Positive and Negative Syndrome Scale (PANSS) total score. The Olanzapine group exhibited better improvement in insight assessed using the G12 item of PANSS and Insight and Treatment Attitudes Questionnaire (ITAQ), more metabolic side effects indexed with total cholesterol, triglycerides levels and weight gain, and a lower medication discontinuation rate than the other SGAs group. Conclusion Although general symptom improvement was similar, olanzapine significantly improved insight and presented less medication discontinuation compared to other SGAs, which might partially explain why patients on olanzapine stayed longer on their medications.
HGF-rs12536657 and Ocular Biometric Parameters in Hyperopic Children, Emmetropic Adolescents, and Young Adults: A Multicenter Quantitative Trait Study

Introduction Even though ocular refractive state is highly heritable and under strong genetic control, the identification of susceptibility genes remains a challenge. Several HGF (hepatocyte growth factor) gene variants have been associated with ocular refractive errors and corneal pathology. Purpose Here, we assess the association of an HGF gene variant, previously reported as associated with hyperopia, and ocular biometric parameters in a multicenter Spanish cohort. Methods An observational prospective multicenter cross-sectional study was designed, including a total of 403 unrelated subjects comprising 188 hyperopic children (5 to 17 years) and 2 control groups: 52 emmetropic adolescents (13 to 17 years) and 163 emmetropic young adults (18 to 28 years). Each individual underwent a comprehensive eye examination including cycloplegic refraction, and topographic and ocular biometric analysis. Genomic DNA was extracted from oral swabs. HGF single nucleotide polymorphism (SNP) rs12536657 was genotyped. Genotypic, allelic, and logistic regression analyses were performed comparing the different groups. A quantitative trait association test analyzing several biometric parameters was also performed using generalized estimating equations (GEEs) adjusting for age and gender. Results No association between rs12536657 and hyperopia was found through gender-adjusted logistic regression comparing the hyperopic children with either of the two control groups. Significant associations between mean topographic corneal curvature and rs12536657 for G/A (slope = +0.32; CI 95%: 0.04–0.60; p=0.023) and A/A (slope = +0.76; CI 95%: 0.12–1.40; p=0.020) genotypes were observed with the age- and gender-adjusted univariate GEE model. Both flat and steep corneal topographic meridians were also significantly associated with rs12536657 for the G/A and A/A genotypes. No association was found between rs12536657 and any other topographic or biometric measurements. Conclusions Our results support a possible role for HGF gene variant rs12536657 in corneal curvature in our population. To our knowledge, this is the first multicenter quantitative trait association study of HGF genotypes and ocular biometric parameters comprising a pediatric cohort.
OpenEC: Toward Unified and Configurable Erasure Coding Management in Distributed Storage Systems

Erasure coding becomes a practical redundancy technique for distributed storage systems to achieve fault tolerance with low storage overhead. Given its popularity, research studies have proposed theoretically proven erasure codes or efﬁ-cient repair algorithms to make erasure coding more viable. However, integrating new erasure coding solutions into existing distributed storage systems is a challenging task and requires non-trivial re-engineering of the underlying storage workﬂows. We present OpenEC , a uniﬁed and conﬁgurable framework for readily deploying a variety of erasure coding solutions into existing distributed storage systems. OpenEC decouples erasure coding management from the storage work-ﬂows of distributed storage systems, and provides erasure coding designers with conﬁgurable controls of erasure coding operations through a directed-acyclic-graph-based programming abstraction. We prototype OpenEC on two versions of HDFS with limited code modiﬁcations. Experiments on a local cluster and Amazon EC2 show that OpenEC preserves both the operational performance and the properties of erasure coding solutions; OpenEC can also automatically optimize erasure coding operations to improve repair performance.
Searching for Old News: User Interests and Behavior within a National Collection

Modeling user interests helps to improve system support or refine recommendations in Interactive Information Retrieval. The aim of this study is to identify user interests in different parts of an online collection and investigate the related search behavior. To do this, we propose to use the metadata of selected facets and clicked documents as features for clustering sessions identified in user logs. We evaluate the session clusters by measuring their stability over a six-month period. We apply our approach to data from the National Library of the Netherlands, a typical digital library with a richly annotated historical newspaper collection and a faceted search interface. Our results show that users interested in specific parts of the collection use different search techniques. We demonstrate that a metadata-based clustering helps to reveal and understand user interests in terms of the collection, and how search behavior is related to specific parts within the collection.
Automatic, Application-Aware I/O Forwarding Resource Allocation

The I/O forwarding architecture is widely adopted on modern supercomputers, with a layer of intermediate nodes sitting between the many compute nodes and backend storage nodes. This allows compute nodes to run more efficiently and stably with a leaner OS, offloads I/O coordination and communication with backend from the compute nodes, maintains less concurrent connections to storage systems, and provides additional resources for effective caching, prefetching, write buffering, and I/O aggregation. However, with many existing machines, these forwarding nodes are assigned to serve a fixed set of compute nodes. We explore an automatic mechanism, DFRA, for application-adaptive dynamic forwarding resource allocation. We use I/O monitoring data that proves affordable to acquire in real time and maintain for long-term history analysis. Upon each job’s dispatch, DFRA conducts a historybased study to determine whether the job should be granted more forwarding resources or given dedicated forwarding nodes. Such customized I/O forwarding lets the small fraction of I/O-intensive applications achieve higher I/O performance and scalability, meanwhile effectively isolating disruptive I/O activities. We implemented, evaluated, and deployed DFRA on Sunway TaihuLight, the current No.3 supercomputer in the world. It improves applications’ I/O performance by up to 18.9×, eliminates most of the interapplication I/O interference, and has saved over 200 million of core-hours during its test deployment on TaihuLight for 11 months. Finally, our proposed DFRA design is not platformdependent, making it applicable to the management of existing and future I/O forwarding or burst buffer resources.
A Gallbladder Carcinoma Patient With Pseudo-Progressive Remission After Hydrogen Inhalation

Background Hydrogen therapy has been reported to convert exhausted programmed cell death receptor (PD-1)+CD8+ T cells to PD-1-CD8+ T cells, in advanced colorectal cancer patients, which is associated with significantly prolonged survival. Case presentation A 72-year-old female patient presented with metastatic gallbladder cancer and underwent symptomatic treatment combined with hydrogen therapy. The tumors were initially enlarged and displayed increased tumor marker expression following hydrogen inhalation therapy, after which they continued to remit, similar to the pseudo-progression that occurs after anti-PD-1 treatment. During one month of hydrogen therapy, the patient’s gallbladder and liver tumors continued to progress, and intestinal obstruction occurred. The intestinal obstruction was gradually relieved after symptomatic treatment, and the metastases in the abdominal cavity gradually decreased in size, anemia and hypoalbuminemia were corrected, and both the lymphocyte and tumor marker levels returned to normal. The patient was able to resume normal life two and a half months after hydrogen inhalation and survived over 10 months. Conclusion This is the first report of pseudo-progression followed by sustained remission after hydrogen inhalation. This phenomenon is similar to the pseudo-progression-remission pattern that occurs following PD-1 antibody treatment. These findings suggest that hydrogen may have an inhibitory effect on PD-1 expression.
Write-Optimized Dynamic Hashing for Persistent Memory

Low latency storage media such as byte-addressable persistent memory (PM) requires rethinking of various data structures in terms of optimization. One of the main challenges in implementing hash-based indexing structures on PM is how to achieve efficiency by making effective use of cachelines while guaranteeing failure-atomicity for dynamic hash expansion and shrinkage. In this paper, we present Cacheline-Conscious Extendible Hashing (CCEH) that reduces the overhead of dynamic memory block management while guaranteeing constant hash table lookup time. CCEH guarantees failure-atomicity without making use of explicit logging. Our experiments show that CCEH effectively adapts its size as the demand increases under the fine-grained failure-atomicity constraint and its maximum query latency is an order of magnitude lower compared to the state-of-the-art hashing techniques.
Is advance knowledge of flow sizes a plausible assumption?

Recent research has proposed several packet, flow, and coflow scheduling methods that could substantially improve data center network performance. Most of this work assumes advance knowledge of flow sizes. However, the lack of a clear path to obtaining such knowledge has also prompted some work on non-clairvoyant scheduling, albeit with more limited performance benefits. We thus investigate whether flow sizes can be known in advance in practice, using both simple heuristics and learning methods. Our systematic and substantial efforts for estimating flow sizes indicate, unfortunately, that such knowledge is likely hard to obtain with high confidence across many settings of practical interest. Nevertheless, our prognosis is ultimately more positive: even simple heuristics can help estimate flow sizes for many flows, and this partial knowledge has utility in scheduling. These results indicate that a presumed lack of advance knowledge of flow sizes is not necessarily prohibitive for highly efficient scheduling, and suggest further exploration in two directions: (a) scheduling under partial knowledge; and (b) evaluating the practical payoff and expense of obtaining more knowledge.
Scaling Community Cellular Networks with CommunityCellularManager

Hundreds of millions of people still live beyond the coverage of basic mobile connectivity, primarily in rural areas with low population density. Mobile network operators (MNOs) traditionally struggle to justify expansion into these rural areas due to the high infrastructure costs necessary to provide service. Community cellular networks, networks built “by and for” the people they serve, represent an alternative model that, to an extent, bypasses these business case limitations and enables sustainable rural coverage. Yet despite aligned economic incentives, real deployments of community cellular networks still face signiﬁcant regulatory, commercial and technical challenges. In this paper, we present CommunityCellularManager (CCM), a system for operating community cellular networks at scale. CCM enables multiple community networks to operate under the control of a single, multi-tenant controller and in partnership with a traditional MNO. CCM preserves ﬂexibility for each community network to operate independently, while allowing the mobile network operator to safely make critical resources such as spectrum and phone numbers available to these networks. We evaluate CCM through a multi-year, large-scale community cellular network deployment in the Philippines in partnership with Globe, the largest MNO in the country, providing basic communication services to over 2,800 people in 17 communities without requiring changes to the existing regulatory framework, and using existing handsets. We demonstrate that CCM can support independent community networks with unique service offerings and operating models while providing a basic level of MNO-deﬁned service. To our knowledge, this represents the largest deployment of community cellular networks to date.
Studying Politicians' Information Sharing on Social Media

In this study, we pair different perspectives on information sharing held by the information behaviour and computational social science communities. By reflecting on different conceptual models of sharing (two-actor vs three-actor model) and applying methods from social network analysis and text mining, we investigate the influence that different user interface features (retweeting and quote retweeting) have on politicians' sharing behaviour during an election campaign on the social media platform Twitter. Amongst other results, our analyses show that the two features are used quite differently with the quote RT feature promoting non-partisan interaction, which leads to a more civilized discourse with opponents and support for colleagues.
Atonal homolog 7 (ATOH7) loss-of-function mutations in predominant bilateral optic nerve hypoplasia.

Optic nerve hypoplasia (ONH) is a congenital optic nerve abnormality caused by underdevelopment of retinal ganglion cells (RGCs). Despite being a rare disease, ONH is the most common optic disc anomaly in ophthalmological practice. So far, mutations in several genes have been identified as causative, however many cases of ONH remain without a molecular explanation. The early transcription factor atonal basic-helix-loop-helix (bHLH) transcription factor 7 (ATOH7) is expressed in retinal progenitor cells and has a crucial role in RGC development. Previous studies have identified several mutations in the ATOH7 locus in cases of eye developmental diseases such as nonsyndromic congenital retinal nonattachment and persistent hyperplasia of the primary vitreous. Here we present two siblings with a phenotype predominated by bilateral ONH, with additional features of foveal hypoplasia and distinct vascular abnormalities, where whole-exome sequencing identified two compound heterozygous missense mutations affecting a conserved amino acid residue within the bHLH domain of ATOH7 (NM_145178.3:c.175G>A; p.(Ala59Thr) and c.176C>T; p.(Ala59Val)). ATOH7 expression constructs with patient single nucleotide variants were cloned for functional characterization. Protein analyses revealed decreased protein amounts and significantly enhanced degradation in the presence of E47, a putative bHLH dimerization partner. Protein interaction assays revealed decreased heterodimerization and DNA-binding of ATOH7 variants, resulting in total loss of transcriptional activation of luciferase reporter gene expression. These findings strongly support pathogenicity of the two ATOH7 mutations, one of which is novel. Additionally, this report highlights the possible impact of altered ATOH7 dimerization on protein stability and function.
CMAR_A_209205 7021..7030

Kentaro Inamura Gulanbar Amori Takeshi Yuasa Shinya Yamamoto Junji Yonese Yuichi Ishikawa 1Division of Pathology, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan; 2Department of Pathology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan; 3Department of Urology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan Background: B7-H3 (CD276), an immune checkpoint molecule, regulates the tumor-immune microenvironment and controls the aggressiveness of various tumors. Although B7-H3 expression has been associated with the number of tumor-infiltrating FOXP3+ regulatory T cells, little information is available about this association in clear cell renal cell carcinoma (ccRCC). Methods: Using 252 consecutive cases of ccRCC, we examined the association of B7-H3 expression in both the tumor cells and tumor vasculature with the number of tumor-infiltrating FOXP3+ cells and assessed whether the effects of B7-H3 expression on survival differ according to FOXP3+ cell number. Results: High B7-H3 expression was observed in the tumor cells and tumor vasculature in 15% and 54% of ccRCC cases, respectively. High FOXP3+ cell number was positively associated with B7-H3 expression in both the tumor cells (odds ratio [OR] =2.93; P=0.0041) and tumor vasculature (OR=2.45; P=0.0007). Tumor cell B7-H3 expression was associated with increased disease-specific mortality in high FOXP3+ cell number group (hazard ratio [HR] =2.98; P=0.017), but not in low FOXP3+ group (P=0.71). Tumor vasculature B7-H3 expression was also associated with increased disease-specific mortality in high FOXP3+ cell number group (HR=4.86; P=0.0025), but not in low FOXP3+ group (P=0.48). Conclusion: We demonstrate that B7-H3 expression in both tumor cells and the tumor vasculature is positively associated with FOXP3+ cell number. Such expression is also associated with increased mortality in high FOXP3+ cell number group, but not in low FOXP3+ cell number group. These findings suggest that B7-H3-expressing ccRCCs may exert tumor-promoting immunity by interacting with FOXP3+ regulatory T cells in the tumor microenvironment.
An Oral Whole-Cell Killed Nontypeable Haemophilus influenzae Immunotherapeutic For The Prevention Of Acute Exacerbations Of Chronic Airway Disease

Abstract In subjects with chronic bronchitis, protection against acute bronchitis following oral administration of a whole-cell killed nontypeable Haemophilus influenzae (NTHi) preparation was demonstrated in the mid-1980s. Subsequently, studies aiming to validate clinical efficacy of this oral treatment were complicated by a number of factors, including the modification of clinical definitions, the implications of which were not recognized at that time. The objective of this review is to integrate our pre-clinical and clinical research in this field conducted over the past 30 years to demonstrate the evolution of the idea of communication between mucosal surfaces through the common mucosal immune system and the development of an effective oral NTHi immunotherapy. Our earliest studies recruited subjects with chronic sputum production and high levels of culture-positive sputum for Gram-negative bacteria but by 2000, the clinical diagnostic focus had switched from “chronic bronchitis” to “chronic obstructive pulmonary disease” (COPD), which was functionally defined using spirometry. This change led to variable clinical trial results, confirming the importance of chronic sputum production and culture-positive sputum. Additional conditioning factors such as patient age and gender were influential in study populations with low culture-positive sputum production. Through this period, studies in human and in rodent models provided new insights into airway protection mechanisms and the pathogenesis of airway inflammation. Key findings were the importance of a dysbiosis within the airway microbiome, and the critical role of an interdependence between the bronchus and the gut, with a Peyer’s patch-dependent extra-bronchus “loop” controlling the composition of the bronchus microbiome. Within this context, intercurrent virus infections initiate a microbiome-dependant hypersensitivity reaction involving Peyer’s patch-derived Th17 cells. We conclude that whole-cell killed NTHi immunotherapy has consistent and significant benefits when examined in the context of changing clinical disease definitions, age and gender, and has the potential to change the natural history of chronic airway disease.
Optimizing Systems for Byte-Addressable NVM by Reducing Bit Flipping

New byte-addressable non-volatile memory (BNVM) technologies such as phase change memory (PCM) enable the construction of systems with large persistent memories, improving reliability and potentially reducing power consumption. However, BNVM technologies only support a limited number of lifetime writes per cell and consume most of their power when flipping a bit’s state during a write; thus, PCM controllers only rewrite a cell’s contents when the cell’s value has changed. Prior research has assumed that reducing the number of words written is a good proxy for reducing the number of bits modified, but a recent study has suggested that this assumption may not be valid. Our research confirms that approaches with the fewest writes often have more bit flips than those optimized to reduce bit flipping. To test the effectiveness of bit flip reduction, we built a framework that uses the number of bits flipped over time as the measure of “goodness” and modified a cycle-accurate simulator to count bits flipped during program execution. We implemented several modifications to common data structures designed to reduce power consumption and increase memory lifetime by reducing the number of bits modified by operations on several data structures: linked lists, hash tables, and red-black trees. We were able to reduce the number of bits flipped by up to 3.56× over standard implementations of the same data structures with negligible overhead. We measured the number of bits flipped by memory allocation and stack frame saves and found that careful data placement in the stack can reduce bit flips significantly. These changes require no hardware modifications and neither significantly reduce performance nor increase code complexity, making them attractive for designing systems optimized for BNVM.
Take Me Out: Space and Place in Library Interactions

Information interactions are strongly affected by the place where they occur. Specific locations are often associated with searches on particular topics, and individual users perform different tasks in habituated places. A classic example of habituated space is the commuter who regularly reads the news on the train. This paper investigates these associations through four user studies that examine different uses of place in information interaction. Through this, we reveal the ways in which the location of information interactions makes them effective or ineffective. This extends our interpretation of the role of place in information interaction beyond established foci such as location-based search.