Miracle-dz/UniFAR-FTUs huggingface dataset:
Anatomical and functional correlation of the endomorphins with mu opioid receptor splice variants

The present study characterizes the relationship between the endogenous mu opioid peptides endomorphin‐1 (EM‐1) and endomorphin‐2 (EM‐2) and several splice variants of the cloned mu opioid receptor (MOR‐1) encoded by the mu opioid receptor gene (Oprm). Confocal laser microscopy revealed that fibers containing EM‐2‐like immunoreactivity (‐LI) were distributed in close apposition to fibers showing MOR‐1‐LI (exon 4‐LI) and to MOR‐1C‐LI (exons 7/8/9‐LI) in the superficial laminae of the lumbar spinal cord. We also observed colocalization of EM‐2‐LI and MOR‐1‐LI in a few fibers of lamina II, and colocalization of EM‐2‐LI and MOR‐1C‐LI in laminae I–II, and V–VI. To assess the functional relevance of the MOR‐1 variants in endomorphin analgesia, we examined the effects of antisense treatments that targeted individual exons within the Oprm1 gene on EM‐1 and EM‐2 analgesia in the tail flick test. This antisense mapping study implied mu opioid receptor mechanisms for the endomorphins are distinct from those of morphine or morphine‐6β‐glucuronide (M6G).
Electroactive haloalkaliphiles exhibit exceptional tolerance to free ammonia

Abstract Electrochemical activity in bacteria has been observed in numerous environments and conditions. However, enrichments in circumneutral freshwater media where acetate is the main electron donor seem to invariably lead to the dominance of Geobacter spp. Here we report on an electroactive bacterial consortium which was enriched on acetate as electron donor, but in a medium which reproduces hydrolysed urine (high pH, high salinity and high free ammonia). The consortium was found to be free of Geobacter species, whereas a previously undescribed community dominated by species closely related to Pseudomonas and Desulfuromonas was established. The salient features of this community were as follows: (i) high electroactivity, with anodic current densities up to 47.4 ± 2.0 A m‐2; (ii) haloalkaliphilicity, with top performance at a medium pH of 10 and 19.5 ± 0.5 mS cm−1; and (iii) a remarkably high tolerance to free ammonia toxicity at over 2200 mgNH3‐N L−1. This community is likely to find applications in microbial electrochemical technology for nutrient recovery from source‐separated urine. Figure. No Caption available.
The clinical and functional outcomes of ultrasound-guided vs landmark-guided injections for adults with shoulder pathology--a systematic review and meta-analysis.

OBJECTIVE To compare the clinical and functional outcomes of US-guided (USG) vs landmark-guided (LMG) injection for the treatment of adults with shoulder pathology. METHOD MEDLINE, AMED and Embase in addition to unpublished literature databases were searched from 1950 to August 2011. Studies were included if they were randomized or non-randomized controlled trials comparing USG vs LSG injections for the treatment of adults with shoulder pathology. Two reviewers independently performed data extraction and appraisal of the studies. Meta-analyses were performed where possible and when inappropriate a narrative review of the data was presented. RESULTS Six papers including 307 patients were reviewed; 142 received LMG injections and 165 received USG injections. There was a statistically significant difference in favour of USG for pain at 6 weeks (standardized mean difference 1.03; 95% CI 0.12, 1.93; P = 0.03). There was no statistically significant difference between the injection methods with respect to shoulder function (standardized mean difference 0.33; 95% CI -0.59, 1.25; P = 0.48). There was a significant difference between interventions for shoulder abduction at 6 weeks in favour of the USG method (mean difference 2.81; 95% CI 0.67, 4.95; P = 0.01). No other movements showed a statistically significant difference. CONCLUSION There is a statistically significant difference in pain and abduction between LMG and USG steroid injections for adults with shoulder pathology. However, these differences are small and may not represent clinically useful differences. The current evidence base is limited by a number of important methodological weaknesses, which should be considered when interpreting these findings. The cost-effectiveness of the intervention should be considered in the design of future studies.
AIS Electronic

Existing studies on information privacy have largely discussed behavioral determinants of information privacy concerns (IPC). There has been a lack of direct examination on the relationship between demographic characteristics of consumers and IPC. The few studies that did report the linkage produced inconsistent findings. In this study, we aimed to investigate the relationship between consumers’ demographic characteristics and IPC with data from a large sample of 9,840 respondents provided by the Korea Information Society Development Institute (KISDI). The results demonstrated that educational attainment and income level exerted effects on IPC in line with existing studies. But the effects of gender and age are different from those identified in existing studies. This study is significant in that by confirming the results of previous studies, it enables generalization of empirical findings. Meanwhile, the results that contrasted previous findings facilitate the discovery of new research topics and discussion.
Direct and flexible marginal inference for semicontinuous data

The marginalized two-part (MTP) model for semicontinuous data proposed by Smith et al. provides direct inference for the effect of covariates on the marginal mean of positively continuous data with zeros. This brief note addresses mischaracterizations of the MTP model by Gebregziabher et al. Additionally, the MTP model is extended to incorporate the three-parameter generalized gamma distribution, which takes many well-known distributions as special cases, including the Weibull, gamma, inverse gamma, and log-normal distributions.
Photon and dilepton production in supersymmetric Yang-Mills plasma

By weakly gauging one of the U(1) subgroups of the R-symmetry group, = 4 super-Yang-Mills theory can be coupled to electromagnetism, thus allowing a computation of photon production and related phenomena in a QCD-like non-Abelian plasma at both weak and strong coupling. We compute photon and dilepton emission rates from finite temperature = 4 supersymmetric Yang-Mills plasma both perturbatively at weak coupling to leading order, and non-perturbatively at strong coupling using the AdS/CFT duality conjecture. Comparison of the photo-emission spectra for = 4 plasma at weak coupling, = 4 plasma at strong coupling, and QCD at weak coupling reveals several systematic trends which we discuss. We also evaluate the electric conductivity of = 4 plasma in the strong coupling limit, and to leading-log order at weak coupling. Current-current spectral functions in the strongly coupled theory exhibit hydrodynamic peaks at small frequency, but otherwise show no structure which could be interpreted as well-defined thermal resonances in the high-temperature phase.
Delivery of Dietary and Lifestyle Interventions in Pregnancy: is it Time to Promote the Use of Electronic and Mobile Health Technologies?

Abstract Fifty percent of women who enter pregnancy are overweight or obese, increasing complications for both the mother and the infant, along with significant burden on individuals and the health care system. Pregnancy represents a “teachable moment” in a woman's life, however, antenatal interventions focusing on improving dietary and physical activity patterns have been associated with modest behavior change. There are many barriers that need to be overcome, including lack of knowledge, access and time pressures. Advancing mobile and electronic health technologies may represent an adjunct tool to support traditional face-to-face consultations and facilitate behavior change, but further rigorous evaluation of the technologies and their impact on health outcomes is required. Well-designed antenatal intervention trials with particular attention to the structure and method of information provision are required to further assess the feasibility of such technology.
A Time-Lag Study of the Effect of Organisational Capital on Innovation in Australia SMEs

This study explores the strategic links between organisational capital and innovation performance in Australian SMEs. This study classified organisational capital as information technology as per hardware and software; and equipment or machinery that was applied in the firm. A sample involving SME from various industries was adapted from the Business Longitudinal Database (BLD) from the Australian Bureau of Statistics (ABS). The analyses validate that information technology capabilities is essential for achieving innovation performance. However the relationship decline over time for different type of innovation. Thus, SME managers should be carefully in investing in appropriate information technology in order to facilitate innovation in their firm. Key Words: SMEs, Organisational capital, Innovation, Australia
Designing Human Health Risk Management Model for Dam Construction Projects

Identifying the risks of dam construction projects due to their high importance in terms of utilization, the amount of investment they invest in, the location of the region, the nature of the complexity of the project, and the presence of many uncertainties, including natural disasters and costs High builds are of special importance. Selection and implementation of the project with the least risk can lead to economic savings, optimal use of resources, increased productivity, flood control and supply of drinking water, agriculture and industry. Based on the results of this study, the "human factors" factor in the probability of occurrence and outcome in the category of severity of risk was the highest score among the indicators related to risk factors assessment of dam construction projects. In this research, first, identify the main risks of the project through a questionnaire and then identify the response strategies for the most critical risks, and finally, with the help of the decision model, prepare and, through paired comparisons, the best strategy for the most important human risk factors in the Polrood dam project is selected. In order to assess the risk in the dam, the risk parameters were identified and prioritized in different stages of the project, as well as 16 sub-subsets in four categories of risk factors: human, technical-environmental, environmental and psychological factors, and using the method DEMATEL-ANP were evaluated and ranked. "The lack of sufficient training to use devices and tools" was the most critical.
Antiangiogenic Therapy: A Universal Chemosensitization Strategy for Cancer?

For more than 50 years, a major goal of research in cancer therapeutics has been to develop universally effective agents that render cancer cells more sensitive to cytotoxic chemotherapy without substantially increasing toxicity to normal cells. The results of recent clinical trials indicate that certain antiangiogenic drugs may produce this long-sought effect. Here, I describe three distinct mechanisms that may help to explain the chemosensitizing activity of these drugs: normalizing tumor vasculature, preventing rapid tumor cell repopulation, and augmenting the antivascular effects of chemotherapy. I then discuss how these potential mechanisms might be exploited to maximize therapeutic efficacy.
Aqueous Extracts of Dried Fruits of Zanthoxylum armatum DC., (Rutaceae) Induce Cellular and Nuclear Damage Coupled with Inhibition of Mitotic Activity in Vivo

Bioactive compounds derived from plant natural compounds have proven to be valuable sources of metabolites which can seldom be obtained from other sources. Plants belonging to the genus Zanthoxylum have been valued across various cultures for their curative properties. Zanthoxylum armatum DC. , belonging to the family Rutaceae is extensively used in traditional practices in North-Eastern India and neighbouring regions including South-East Asia. However, the potential cytogenetic effects of Zanthoxylum armatum under in vivo conditions, and their causative mechanisms have not yet been studied in detail. The current study was undertaken to evaluate the cytotoxic and genotoxic potential of aqueous extracts of fruits of Z. armatum under in vivo conditions using the Allium test. Physiological and cellular data indicate that the extracts induce clumped chromosomes at metaphase stage of cell division coupled with mitotic arrest. Electron microscopy data reveal membrane damage of cellular organelles, chromatin condensation and chromatin marginalisation in cell of roots incubated in the extracts. The extracts also induce concentration dependent protein precipitation and genomic DNA degradation.
The Role of Ethnic Identity in the Relationship of Race-Related Stress to PTSD Symptoms Among Young Adults

ABSTRACT Although many studies have shown that stronger ethnic identity is associated with better adjustment, the role of ethnic identity in the context of race-related threat is unclear. The purpose of this study was to examine the effect of ethnic identity on the severity of posttraumatic stress disorder (PTSD) symptoms in the context of race-related stress, particularly to examine whether ethnic identity moderates the effect of racism on consequent PTSD symptoms. Subjects were 91 undergraduate students (11% Caucasian, 6.6% African American, 18.7% Hispanic, 47.3% Asian, 5.5% Middle Eastern, and 8.8% Other) who reported experiences of race-related stress. Race-related stress, ethnic identity, and PTSD symptoms were assessed through self-report measures. Results of a simultaneous multiple regression indicated that ethnic identity moderated PTSD symptoms in response to perceived racism, such that stronger ethnic identity was associated with more PTSD symptoms in the face of increasing levels of race-related stress. Additionally, race-related stress independently predicted PTSD symptoms. These results are consistent with previous findings that ethnic identity increases the experience of distress in the context of self-relevant threa.
Anabolic therapy with Equisetum arvense along with bone mineralising nutrients in ovariectomized rat model of osteoporosis

Objective: Equisetum arvense has been used to treat bone diseases. The traditional supplementation of calcium and Vitamin D for osteoporosis patients is insufficient considering the rise in patients every year. We have observed that extending the calcium and Vitamin D supplement with L-lysine, L-proline, L-arginine, and L-ascorbic acid (N) positively affects bone mineralization in ovariectomized rat. Here, we report a further extension of the above supplement with E. arvense. Materials and Methods: The changes in serum biomarkers, bone mineral content, and femur bone histology were studied and compared to the standard drug for osteoporosis, namely raloxifene (RAL). Results: We report a significant change in formation and resorption markers of bone as well as in cortical bone thickness and trabecular width in N and N + EA groups. The treatment N + EA also restored lipid profile near to normal level compared to ovariectomized group. Conclusions: Treatment N + EA was found to be as effective as RAL in reversing the osteoporotic changes.
Absorption of the Bone Fragment in Shoulders With Bony Bankart Lesions Caused by Recurrent Anterior Dislocations or Subluxations

Background: Recently, bony defects of the glenoid in patients with traumatic anterior shoulder instability have been increasingly noticed. The bone fragment of a bony Bankart lesion is often utilized for Bankart repair, but the fragment is at times smaller than the glenoid defect. The reason for this mismatch in size is unknown. Hypothesis: The bone fragment of a bony Bankart lesion might gradually be absorbed over time. Study Design: Case series; Level of evidence, 4. Methods: A total of 163 shoulders were prospectively examined by computed tomography. In shoulders with bony Bankart lesions, glenoid defects and bone fragment absorption were assessed, and findings were compared with the time elapsed after the primary traumatic episode. When a bone fragment was not detected despite loss of the normal contour of the glenoid rim, the findings were classified as erosions if the rim appeared round and slightly compressed and classified as complete bone fragment absorption if the rim appeared straight and sharp. Results: There were no glenoid defects in 55 shoulders, erosions in 16 shoulders, and glenoid defects in 92 shoulders. The size of the glenoid defect was 0% to 10% in 15 shoulders, 10% to 20% in 44, 20% to 30% in 26, 30% to 40% in 6, and 40% to 50% in 1. The average defect size was 7.9% in shoulders scanned at <1 year, 10.7% between 1 and 2 years, and 11.3% at >2 years, indicating no relationship with time after trauma. Regarding bone fragment absorption, all 92 shoulders with glenoid defects showed absorption to some extent. The extent of absorption was <50% in 32 shoulders, >50% in 45, and 100% in 15. The average extent of absorption was 51.9% in shoulders scanned at <1 year, 65.3% between 1 and 2 years, and 70.0% at >2 years, indicating a significant relationship with time after trauma. Conclusion: Bone fragment absorption was seen in all of the shoulders with bony Bankart lesions. Most bone fragments showed severe absorption within 1 year after the primary traumatic episode. Before arthroscopic Bankart repair, not only glenoid defects but also bone fragment absorption should be assessed.
Thrombolytic therapy of acute ischemic stroke during pregnancy

The authors report eight pregnant women with acute ischemic stroke treated with thrombolysis (rt-PA [recombinant human tissue plasminogen activator] or urokinase). Seven women recovered. Two extracranial and two asymptomatic intracranial hemorrhages complicated treatment; one woman died of arterial dissection complicating angiography. Three patients had therapeutic abortions, two fetuses were miscarried, and two babies were delivered healthy. Although pregnant women may be treated safely with thrombolytics, risks and benefits to mother and fetus must be carefully weighed.
The Decline in Human Seasonality

Investigations on human seasonality go back almost 180 years (Quetelet, 1826, 1869; Villermé, 1831). The majority of these focused on the annual reproduction rhythm, which reflects a seasonality in successful conceptions (Aschoff, 1981; Roenneberg and Aschoff, 1990a). Phase, amplitude, and waveform of conception rhythms vary with region and—in industrialized countries—also over time. Seasonal reproduction in plants and animals can be “all or none” or, like human conception, merely modulated. The largest amplitudes in human fecundity are found in preindustrialized countries, around latitudes of 30° N. , with 60% more children born at the peak compared to the trough. Many factors have been suggested to account for these annual regularities, ranging from social to environmental/biological. In view of the ubiquitous role of photoperiodism in plants and animals, it is fair to speculate about the role of photoperiodism in humans. In his paper, Bronson (2004 [this issue]) provides an excellent review of the existing literature, highlights “inconsistencies,” and offers a new hypothesis. He argues that the different shapes of the annual birth rhythms around the globe could be explained by assuming that human populations are a mixture of photoperiodic responders and nonresponders. This comment challenges both the interpretation of the existing data on which his hypothesis is based and the hypothesis itself. HOW IS AMERICA NOT LIKE EUROPE?
Carcinoembryonic antigen in serum in diseases of the liver and pancreas

Carcinoembryonic antigen (CEA) was measured in whole serum and in serum extracted with perchloric acid by microradioimmunoassay in patients with benign and malignant diseases of the liver and pancreas. The level of detectability was 5 ng per ml. This level or greater was present in the serum of 50% of patients with chronic diffuse liver disease, 64% with pancreatitis, 94% with cancer of the digestive system, and 3% of controls. The incidence of levels of CEA of 5 ng/ml or more differed for various categories of chronic liver disease: from 22% in active chronic hepatitis, 46% in primary biliary cirrhosis, 63% in hepatoma, 78% in cryptogenic cirrhosis, and 88% in alcoholic cirrhosis; levels of CEA correlated with degrees of impairment of liver function as judged by bromsulphalein retention and serum levels of alkaline phosphatase and transaminase. In pancreatitis, 64% of cases had levels of CEA ranging from 5 to 20 ng/ml and in cancer of the pancreas 94% had levels above 5 ng/ml and 50% above 20 ng/ml.
Lipid Rafts As a Membrane-Organizing Principle

Lipid Rafts Come of Age Living cells are surrounded by cellular membranes composed of lipids and proteins. Much attention has been paid to the biogenesis and sorting of membrane proteins. The dynamics and sorting of lipids have been much more difficult to study. Lingwood and Simons (p. 46) review the evidence for, and the role played by, so-called lipid rafts—laterally segregated regions within membranes enriched for particular lipids and proteins. Cell membranes display a tremendous complexity of lipids and proteins designed to perform the functions cells require. To coordinate these functions, the membrane is able to laterally segregate its constituents. This capability is based on dynamic liquid-liquid immiscibility and underlies the raft concept of membrane subcompartmentalization. Lipid rafts are fluctuating nanoscale assemblies of sphingolipid, cholesterol, and proteins that can be stabilized to coalesce, forming platforms that function in membrane signaling and trafficking. Here we review the evidence for how this principle combines the potential for sphingolipid-cholesterol self-assembly with protein specificity to selectively focus membrane bioactivity.
PENGARUH HARGA DAN PROMOSI GRAB TERHADAP BRAND IMAGE YANG MEMPENGARUHI KEPUTUSAN PEMBELIAN KONSUMEN PENGGUNA TRANSPORTASI BERBASIS ONLINE

This research aims to understand the influence of the price set and promotional activities of Grab towards consumer purchase decision of through brand image as intervening variables. This research is a quantitative research. A number of samples taken are 205 people using people purposive sampling technique. the measurement used was the questionnaire that was disseminated through Google Form and analysis using SPSS 20. The results of hypothesis analysis show that price influence significantly to brand image; promotion influence significantly to brand image; price influence significantly to purchase decision; promotion influence significantly to purchase decision, and brand image influence significantly to purchase decision. Keywords: price, promotion, consumer purchase decision, brand image