Miracle-dz/UniFAR-FTUs huggingface dataset:
BUSINESS-ORIENTED SOCIAL NETWORKING SITES ( B-SNS ) STICKINESS : ITS ANTECEDENTS AND OUTCOME ON INTENTION TO PURCHASE APPAREL

With the Internet of Things rapidly becoming a reality and devices connecting every aspect of consumers’ lives, the shift to a new, connected world signals another tidal wave of industry transition. Based on previous survey by Indonesian Internet Service Provider Association (APJII) and University of Indonesia published on April 2015 indicate that consumers find smart devices increasingly relevant to their lives, and are inspired by the possibilities of the connected world. Since online consumers can easily switch to other e-commerce sites, their online loyalty is generally not high. How to attract the attention of online consumers and make them stick with the website has become a big challenge for e-commerce companies. The purpose of this paper is to provide an improved understanding of the influential factors on the duration spent in business-oriented social networking sites (B-SNS) and retention B-SNS, or in other words, B-SNS stickiness. Empirical evidence from both depth interviews and data garnered from 230 surveys were integrated into a conceptual model. The model was tested using structural equation modeling. The causal model was validated using SmartPLS 2.0. The results indicated that B-SNS stickiness were important antecedent of intention to purchase apparel and mediated the influence of B-SNS browser satisfaction, user satisfaction, and environment. This study is expected to provide insight on strategies to encourage entrepreneurs to adopt B-SNS in the future. This study further contributes by providing comprehensive framework of the antecedents and outcome of B-SNS stickiness on intention to purchase apparel.
International hostility and aggressiveness on the soccer pitch: Evidence from European Championships and World Cups for the period 2000–2012

Some researchers consider soccer matches as the stylization of a war in other battlefields. Such an approach has largely been used to interpret the violent phenomena related to the soccer environment, while less attention has been paid to the potential role of political and economic interactions between countries in determining the aggressive attitude of players on the pitch. In our paper we empirically investigate whether and how political hostility among countries reverberates on a soccer pitch by influencing players’ aggressiveness. The analysis focuses on official matches played by national teams in the final phases of the European and World Cup tournaments since 2000. We estimate a negative binomial regression including both political and sport variables, and we find that (a) commercial hostility, (b) the level of diplomatic relationships, (c) power asymmetry and (d) education gap between countries are positively and significantly associated with aggressiveness of the players on the pitch, approximated by the number of yellow and red cards. That is, briefly stated, international hostility reverberates onto the pitch. Moreover, sport covariates present the expected signs, namely, results show that the closeness of the teams, their ranking and the stage of the game (knockout stages with respect to the group phases) are also crucial in determining the cautions.
Molecular analysis of the signaling pathway between EnvZ and OmpR in Escherichia coli

OmpR is a DNA-binding protein that regulates transcription of ompF and ompC. The activity of OmpR is controlled by the inner membrane osmosensor, EnvZ. In order to study the signaling process between EnvZ and OmpR, we analyzed two different envZ strains: the envZ473 strain, in which OmpC is constitutively produced and OmpF is fully repressed, and the envZ3 strain, in which the production of OmpC is greatly reduced and OmpF is not fully repressed by high-osmolarity growth conditions. Using direct sequencing of DNA derived from the polymerase chain reaction amplification method, we identified the mutation in the envZ473 strain as a Val-241-to-Gly substitution and the mutation in the envZ3 as an Ala-219-to-Val substitution. The relative DNA-binding affinity of OmpR derived from the envZ473 strain was dramatically increased for the upstream sequence of both ompF and ompC. In contrast, OmpR derived from the envZ3 strain was not converted to the high-affinity form. The intracellular levels of OmpR-phosphate, as analyzed by the in vivo phosphorylation approach, significantly increased in the envZ473 strain, while in the envZ3 strain the levels were considerably reduced, relative to those found in the parent strain. The intracellular level of OmpR protein in the envZ473 strain was also found to be markedly elevated relative to that of the parent strain. These results are discussed in relation to the role of phosphorylation and relative DNA-binding affinity of OmpR in the expression of ompF and ompC.
Anthrax lethal factor cleaves the N‐terminus of MAPKKS and induces tyrosine/threonine phosphorylation of MAPKS in cultured macrophages

The lethal toxin (LeTx) of Bacillus anthracis is the major virulence factor responsible for the death of infected animals and for cytolysis of cultured macrophages. Its catalytic component, LF, contains the characteristic zinc‐binding motif of metalloproteases, it binds zinc and indirect evidence suggests that this hydrolytic activity is essential for LeTx cytotoxicity ( Limpel et al. 1994 ; Kochi et al. 1994 ). To identify substrates of LF, we have used the yeast two‐hybrid system, employing an LF inactive mutant as bait. This approach has led to the identification of the MAP kinase kinases (MAPKKs) Mek1 and Mek2 as proteins capable of specific interaction with LF. LF cleaves Mek1 and Mek2 within their N‐terminus in vitro and in vivo, hydrolysing a Pro8‐Ile9 and a Pro10‐Arg11 peptide bond in Mek1 and Mek2, respectively ( Vitale et al. 1998 ), similarly to that found with a different approach by Duesbery et al. (1998) . The removal of the amino terminus of MAPKKs eliminates the ‘docking site’ involved in the specific interaction with MAPKs and interferes with the phospho‐activation of the MAPKs ERK1 and ERK2, which become phosphorylated in cultured macrophages following toxin challenge. We are currently investigating the relevance of MAPKKs cleavage for LeTx cytotoxicity and the consequences for the activity of the MAP pathway.
Cross‐sectional area reference values for nerve ultrasonography

Ultrasound allows for a non‐invasive structural assessment of nerves, muscles, and surrounding tissues, and therefore it is increasingly being used as a supplement to traditional electrodiagnostic studies. As investigators have begun to use ultrasound to explore peripheral nerves, it has become clear that conditions such as entrapment, hereditary neuropathies, acquired neuropathies, trauma, and nerve tumors result in an increase in nerve cross‐sectional area. Reference values have not been published for the cross‐sectional area of many nerves commonly studied in diseases of the peripheral nervous system, so our goal was to obtain reference values for the nerve cross‐sectional area at the following sites: radial at antecubital fossa; radial at distal spiral groove; musculocutaneous in upper arm; trunks of the brachial plexus; vagus at carotid bifurcation; sciatic in distal thigh; tibial in popliteal fossa; tibial in proximal calf; tibial at ankle; peroneal in popliteal fossa; peroneal at fibular head; and sural in distal calf. Mean cross‐sectional area, as well as side‐to‐side differences, are reported for each site, and qualitative data are provided to guide imaging at each site. The information provided in this study should serve as the starting point for quantitatively evaluating these nerve sites with ultrasound. Muscle Nerve, 2008
An empirical note on the holiday effect in the Australian stock market, 1996–2006

This note examines the holiday effect in Australian daily stock returns at the market and industry level and for small capitalization stocks from Monday 9 September 1996 to Friday 10 November 2006. The eight annual holidays specified are New Years Day, Australia Day (26 January), Easter Friday and Easter Monday, ANZAC Day (25 April), the Queen's Birthday (second Monday in June), Christmas Day and Boxing Day. A regression-based approach is employed. The results indicate that the Australian market overall provides evidence of a pre-holiday effect in common with small cap stocks. However, the market level effect appears to be solely the result of a strong pre-holiday effect in the retail industry. No evidence is found of a post-holiday effect in any market or industry.
Upc2p‐associated differential protein expression in Candida albicans

The gain‐of‐function mutation G648D in UPC2 causes ERG11 up‐regulation and increased fluconazole resistance in Candida albicans. In this study, we performed 2‐DE and PMF to identify proteomic alterations in an ERG11‐overexpressing fluconazole‐resistant C. albicans clinical isolate compared with its fluconazole‐susceptible parent strain. We identified 23 differentially expressed proteins, and among them, seven became differentially expressed in a C. albicans wild‐type strain after the introduction of a UPC2 allele carrying this mutation. These Upc2p‐regulated proteins may contribute to fluconazole resistance in C. albicans.
Intracellular ethanol accumulation in Saccharomyces cerevisiae during fermentation

An intracellular accumulation of ethanol in Saccharomyces cerevisiae was observed during the early stages of fermentation (3 h). However, after 12 h of fermentation, the intracellular and extracellular ethanol concentrations were similar. Increasing the osmotic pressure of the medium caused an increase in the ratio of intracellular to extracellular ethanol concentrations at 3 h of fermentation. As in the previous case, the intracellular and extracellular ethanol concentrations were similar after 12 h of fermentation. Increasing the osmotic pressure also caused a decrease in yeast cell growth and fermentation activities. However, nutrient supplementation of the medium increased the extent of growth and fermentation, resulting in complete glucose utilization, even though intracellular ethanol concentrations were unaltered. These results suggest that nutrient limitation is a major factor responsible for the decreased growth and fermentation activities observed in yeast cells at higher osmotic pressures.
Developmental changes in translatable RNA species associated with meiosis and spore formation in Saccharomyces cerevisiae

During Saccharomyces cerevisiae sporulation distinct changes in translatable mRNA species have been detected by two-dimensional gel electrophoresis of the polypeptides produced in a messenger-dependent, cell-free rabbit reticulocyte lysate primed with RNA prepared from a/alpha, a/a, and alpha/alpha isogenic diploids at different stages of sporulation. The availability of functional mRNA increased by about 25% during the first 4 h after transfer of either sporulating (a/alpha), or nonsporulating (a/a and alpha/alpha) diploids to sporulation medium. Thereafter functional mRNA decreased such that in the a/alpha strain after 24 h there was only about 50% of the amount in vegetative cells; a less marked decrease was observed in the a/a and alpha/alpha strains. Of 750 mRNA species detected, 43 underwent alterations only during sporulation in the a/alpha strain, whereas 36 changes were common to all three strains and one mRNA specific to alpha/alpha vegetative cells was detected. Only four of the sporulation-specific changes were due to the de novo appearance of translatable species, and two of these became predominant species of the total population. The majority of the specific changes were due to either permanent or transient increases in the concentration of individual mRNA species; 11 decreases were found. Changes were found at most stages of sporulation, although many occurred in either of two stages, one early (before 2 h) and the other later (between 6 and 8 h) when commitment to meiotic segregation was beginning. The results provide evidence for both quantitative and, to a lesser extent, qualitative transcriptional control of gene expression during sporulation.
Is Dual-Task Performance Necessarily Impaired in Space?

Recent single-subject experiments in space have reported impaired dual-task performance that could result from either a direct effect of microgravity on the central nervous system or from the multistressor environment. We sought to distinguish between these hypotheses using 6 astronauts in the 16-day NASA Neurolab mission, testing them at intervals with a dual task consisting of primary pursuit tracking without vision of the hand and secondary reaction time (RT). The participants were highly trained, instructed to maintain a fixed attention strategy, and restrained in the apparatus. The results showed that absolute and variable tracking error, as well as correct RT and the standard deviation of RT, were unimpaired. However, RT errors became more variable, an effect attributed to a decrease in strategic control. We conclude that the impairments observed in previous dual-task space experiments can be attributed to stressors rather than to microgravity and that performance deficits are probably not a necessary concomitant of space flight if attention is paid to task design and astronaut training.
Impediments to Information Systems Replacement: A Calculus of Discontinuance

Abstract Relatively little attention has been directed toward examining information system (IS) obsolescence and replacement despite the significant organizational resources invested in such systems. Current understanding is, as a result, both incomplete and relatively preliminary in nature. In particular, there is an important need for research that identifies impediments to system replacement. We therefore draw on protection motivation theory to formulate a model of IS discontinuance that explains how the replacement of obsolete systems is constrained by the risks associated with replacing these systems, the resources that have been invested in them, their complexity, and institutionalized norms that reflect dominant views concerning preferred IS solutions. Partial least squares (PLS) and covariance based structural equation modeling (SEM) of survey data obtained from 112 senior-level IS managers indicates that replacement risks contribute to decreased replacement intentions while system investments and complexity are linked to increased replacement risks. Institutional norms were also found to indirectly contribute to replacement risks through their positive influence on system investments. The proposed model of discontinuance calculus thus demonstrates the importance of managing risks, system complexity, and system investments to ensure that obsolete systems do not become a significant impediment to organizational effectiveness.
Exploring the Impact of Cognition on Young Children's Ability to Navigate a Speech-Generating Device

Abstract This study examined the impact of cognition on young children's ability to navigate a speech-generating device (SGD) with dynamic paging. Knowledge of which cognitive factors impact navigational skills could help clinicians select the most appropriate SGD for children who have complex communication needs. A total of 65 typically developing children aged 48–77 months were assessed using the Leiter International Performance Scale-Revised (Leiter-R) and the Automated Working Memory Assessment (AWMA). Although significant correlations were found between the ability to navigate an SGD (using a taxonomic organization) and all cognitive factors except for cognitive flexibility, a stepwise linear regression revealed that sustained attention, categorization, and fluid reasoning were the most pragmatic set of factors to predict navigational skills. Future studies are needed to further understand the factors that impact children's navigational skills.
Smoking and buccally administered nicotine. Acute effect on uterine and umbilical artery Doppler flow velocity waveforms.

The effects of maternal smoking and buccal nicotine exposure on uterine and umbilical artery blood flow velocity waveforms were studied in 47 healthy women during late pregnancy. Systolic:diastolic ratios of recorded waveforms were calculated before and after each woman smoked one cigarette containing 1.2 mg of nicotine. The same protocol was followed at a subsequent clinic visit, when each woman chewed a piece of nicotine polacrilex containing 2 mg of nicotine. No significant changes could be induced in either nonsmokers or prior smokers, nor were any significant changes measured in the uterine vessels of any patient subgroup. A significant decrease (P less than .01) in umbilical artery diastolic blood flow velocities was measured after smoking in all habitual smokers after chewing nicotine polacrilex and in those who smoked greater than 10 cigarettes per day (P less than .05). All the measured changes returned to baseline levels by 10 minutes after cessation of exposure. Similar changes in the umbilical artery flow velocity waveforms after exposure to a cigarette and nicotine polacrilex implicated nicotine as a probable cause. Failure to observe significant changes except in habitually smoking women suggests a receptor-mediated response. The finding of altered umbilical artery flow velocity waveforms in the absence of demonstrable changes in the uterine vessels indicates a direct toxic effect of maternal nicotine exposure on the fetal cardiovascular system.
[Endotracheal tube selection in children: which is the better predictor for the selection, tracheal internal diameter in X-ray photograph or age-based formula?].

BACKGROUND Age-based formula has been widely used to predict the appropriate size of the endotracheal tube in children. Tracheal internal diameter in X-ray photograph is reported to show higher correlation with a correct tube than age. In our institution, X-ray photographs were stored as digital images, enabling us to measure tracheal internal diameters more accurately than conventional X-ray films. Therefore, we investigated whether tracheal size in digital X-ray photograph is a better predictor for the tube selection than age. METHODS We reviewed data from children aged 1 to 8 years for the past 5 years. The data included age, tracheal internal diameter at 6th cervical (C6), 2nd thoracic vertebrae (T2) in X-ray photograph and selected tube size. The tube size was estimated by the age-based formula or on the basis of tracheal size. RESULTS The endotracheal tube size correlated significantly with the age, and tracheal internal diameter at C6 or T2 in X-ray photograph (correlation coefficients P=0.898, 0.653, and 0.771 respectively; P<0.0001). The tube size predicted by the age allowed appropriate intubation in 62.2%, but that by the tracheal size at C6 and T2 in 42.8% and 43.7% respectively. CONCLUSIONS The age-based formula is more reliable and appropriate to decide the size of endotracheal tube for children than the tracheal size.
Hydrodynamics of the Molten Metal During the Crater Formation on the Cathode Surface in a Vacuum Arc

2-D axially symmetric hydrodynamic model has been developed to describe the formation of a crater and liquid-metal jets on a vacuum arc cathode using Navier-Stokes equations for an incompressible viscous fluid with a free surface and a heat conduction equation taking convective heat transfer into account. The formation of an elemental crater on a copper cathode during the operation of a cathode spot cell has been numerically simulated by varying the heat flux and the pressure produced by the cathode spot plasma. Based on the simulation results, we can distinguish three different modes of the crater formation process: 1) no splashing; 2) inertial splashing; and 3) active splashing. It has been shown that a crater with metal jets forced away can be formed within 30 ns of plasma action if the heat flux density is above 1012 W/m2 and the pressure is above 108 Pa.
Evaluation of a video telescopic operating microscope (VITOM) for pediatric surgery and urology: a preliminary report.

INTRODUCTION Optical magnification is an essential tool in the practice of pediatric surgery. Magnifying loupes are the most frequently used instrument, although their use often comes at the expense of neck pain experienced by the operating surgeon. Recent advances have led to the development of a compact video microscope (VITOM(®); Karl Storz Endoscopy GmbH, Tuttlingen, Germany) that displays high-definition magnified images on a flat screen. This study was designed to evaluate VITOM as a potential substitute for loupes in complex open pediatric procedures and to explore VITOM as an effective intraoperative teaching modality for open surgery. SUBJECTS AND METHODS Three surgeons used the VITOM II exoscope in 20 operations: 14 hypospadias repairs, 2 inguinal hernia repairs, 1 sacrococcygeal teratoma resection, 1 recurrent tracheoesophageal fistula repair, and 2 additional procedures. Surgeons, trainees, and surgical technicians subjectively evaluated image quality; surgeons evaluated handling of VITOM, degree of neck strain, and fatigue. Three midlevel surgical trainees assessed the VITOM potential for teaching value. Overall impressions of each group and consensus opinions were generated. RESULTS All procedures were completed without complication. The consensus opinion of the entire group was that image quality was excellent. The surgeons found VITOM easy to use, and all agreed that neck strain and fatigue were reduced. Surgical trainees felt that VITOM imaging aided in their understanding of procedures and anatomy. Surgical technicians perceived improved operation flow through better visualization of the procedure. CONCLUSIONS VITOM provides excellent visualization of pediatric operations with improved surgeon comfort and may serve as a substitute for loupes. Secondarily, we found enhanced trainee learning and potential improvement in the flow of surgical procedures. Further study of VITOM with a larger sample size and validated tools is needed.
Volatile and Glycosidically Bound Composition of Loureiro and Alvarinho Wines

Composition of Loureiro and Alvarinho wines from the Vinhos Verdes region, regarding free volatile compounds as well as glycosidically bound aroma precursors, was exhaustively determined by gas chromatography—mass spectrometry after adsorption on XAD-2 resin. On the whole, were identified and quantified 120 volatile compounds in the free fraction and 77 glycosidically bound compounds, belonging to C6-compounds, alcohols, fatty acids ethyl esters, esters of organic acids, acetates, monoterpenic alcohols, monoterpenic oxides and diols, C13-norisoprenoids, volatile phenols, volatile fatty acids, and carbonyl compounds. Globally, the wines of the two cultivars present similar composition on volatiles. However, regarding varietal compounds, Loureiro wines were richer than Alvarinho ones with respect to C6-compounds and monoterpenic compounds, occurring the opposite for volatile phenols. It was also demonstrated that wines of both varieties might benefit the aroma reserve, present as glycoconjugates, as it is susceptible of being technologically explored. Linalool, Ho-trienol, (α-terpineol, contributing with fruity and floral notes, and (β-damascenone mostly for Alvarinho, confering tropical fruit notes, are the varietal compounds which may particularly influence the aroma of these wines. Respecting fermentative compounds, Alvarinho is also particularly rich in fatty acids ethyl esters related to lipid metabolism and acetates of fusel alcohols, which can provide it a fruity character; Loureiro contains higher levels of esters of organic acids and 2-phenylethanol, conferring fruity and floral notes. Sensory analysis agreed with chemical analyses showing a pronounced tree and tropical fruit character for Alvarinho wines while Loureiro wines present more intense citrus fruit notes.