Miracle-dz/UniFAR-FTUs huggingface dataset:
Swimming Exercise Ameliorates Elevated Blood Pressure and Vascular Endothelial Dysfunction in Old Rats

Background and Aim: Advancing age increases the risk of cardiovascular diseases, resulting in higher rates of morbidity and mortality. We tested the hypothesis that habitual swimming exercise would reverse age-related systolic hypertension, vascular dysfunction, hyperactivity of sympathetic nervous system, dyslipidemia, and oxidative stress. Methods: Thirty male Wistar albino rats were used in the present study. Rats were divided (10/group) into young (3-4 months), old sedentary (22-24 months), and old exercised (6 weeks swimming protocol) rats. Systolic blood pressure (SBP), endothelial function, sensitivity of sympathetic nervous system, and renal artery Doppler flowmetry were evaluated. Serum lipids, renal biomarkers and oxidant-antioxidant status were assessed. Results: SBP was significantly higher (100 ± 4.83 vs 80 ± 3.34 mmHg) in old sedentary when compared to young rats, and was associated with reduced endothelial-dependent dilation (EDD), increased sympathetic adrenergic vasoconstriction, dyslipidemia, reduced renal artery blood flow velocity (RBFV), and increased renal artery resistance (RAR). Swimming exercise restored SBP, EDD, sympathetic adrenergic vasoconstriction, serum lipids, RBFV, RAR, to levels almost comparable to young rats. Swimming increased significantly total antioxidant capacity in old exercised rats (2.37 ± 0.33 vs. 1.92 ± 0.44 mM /L), while serum malondialdhyde was decreased (2.58 ± 0.23 vs. 4.42 ± 0.14 ηM/L), when compared to old sedentary rats. All results were statistically significant (p < 0.05). Conclusion: We report here that habitual swimming ameliorates age-dependent systolic hypertension and endothelial dysfunction possibly by anti-oxidant mechanism.
Plasticity in the Link between Pain-Transmitting and Pain-Modulating Systems in Acute and Persistent Inflammation

There is strong evidence that spinoparabrachial neurons in the superficial dorsal horn contribute to persistent pain states, and that the lateral parabrachial complex (PB) conveys relevant nociceptive information to higher structures. The role of PB itself in hyperalgesia and how it recruits descending facilitation has nevertheless received significantly less attention. The current study is a first step toward delineating the functional dynamics of PB and its link to descending control in acute and persistent inflammatory pain. In lightly anesthetized rats, we recorded behavioral withdrawal evoked by mechanical stimulation of the hindpaw and, simultaneously, the activity of identified pain-modulating neurons, “ON-cells” and “OFF-cells,” in the rostral ventromedial medulla (RVM). This was done before and after the inactivation of PB, contralateral or ipsilateral to an inflamed paw [1 h, 1 d, or 5–6 d after intraplantar injection of Complete Freund's Adjuvant (CFA)]. The inactivation of contralateral, but not ipsilateral, PB interfered with nociceptive input to RVM under basal conditions, as well as in acute inflammation. By contrast, blocking ipsilateral, but not contralateral, PB in established inflammation interfered with behavioral hyperalgesia and ON-cell and OFF-cell responses. The lesioning of contralateral PB before CFA injection prevented this recruitment of ipsilateral PB in persistent inflammation. These experiments show that contralateral PB is required to initiate hyperalgesia, which is then maintained by ipsilateral PB, most likely in both cases via the engagement of pain-modulating neurons of the RVM. SIGNIFICANCE STATEMENT The lateral parabrachial complex (PB) relays nociceptive information to brain circuits that are important for the transmission and modulation of pain, but its specific role in persistent pain and engagement of descending control mechanisms has received relatively little attention. We show here that PB contralateral and ipsilateral to an inflammatory insult demonstrate different functions as inflammation persists, likely by engaging pain-facilitating neurons of the rostral ventromedial medulla. While the contralateral PB, the target of the major spinoparabrachial pathway, relays acute nociceptive information, the ipsilateral PB is recruited or unmasked in persistent inflammation to maintain hyperalgesia. These data point to plasticity in the PB itself or its direct and indirect connections with pain-modulating systems as central to the development and maintenance of persistent pain.
Toenail-Based Metal Concentrations and Young-Onset Breast Cancer

Several metals have carcinogenic properties, but their associations with breast cancer are not established. We studied cadmium, a metalloestrogen, and 9 other metals-arsenic, cobalt, chromium, copper, mercury, molybdenum, lead, tin, and vanadium--in relation to young-onset breast cancer (diagnosis age <50 years), which tends to be more aggressive than and have a different risk profile from later-onset disease. Recent metal exposure was measured by assessing element concentrations, via inductively coupled plasma mass spectrometry, in toenail clippings of 1,217 disease-discordant sister pairs in the US-based Sister (2003-2009) and Two Sister (2008-2010) studies. Conditional logistic regression was used to calculate odds ratios and 95% confidence intervals. After correcting for differential calendar time of sample collection, no statistically significant associations were observed between any metals and breast cancer. Vanadium had the largest odds ratio (for fourth vs. first quartile, odds ratio = 1.36, 95% confidence interval: 0.84, 2.21; P for trend = 0.17). Cadmium was associated with a small increase in risk, with no evidence of a dose-response relationship (for fourth vs. first quartile, odds ratio = 1.15, 95% confidence interval: 0.82, 1.60; P for trend = 0.67). Positive associations between urinary cadmium concentrations and breast cancer have been reported in case-control studies, but we observed no such association between young-onset breast cancer and toenail concentrations of any assessed metals.
Breakfast Choice Is Associated with Nutrient, Food Group and Discretionary Intakes in Australian Adults at Both Breakfast and the Rest of the Day

Breakfast choice is correlated with daily nutrient intakes, but this association may not be solely explained by the breakfast meal. We profiled breakfast consumer groups among Australian adults and compared the role that breakfast versus the rest of the day had on daily intakes of the Five Food Groups, discretionary foods, and nutrients. Breakfast groups were breakfast cereal consumers, non-cereal breakfast consumers, and breakfast skippers. One-day dietary recall data from the 2011–2012 National Nutrition and Physical Activity Survey were analysed (n = 9341, ≥19 years), as well as socio-demographic and anthropometric measures. Twelve per cent of adults were breakfast skippers, 41% were breakfast cereal consumers, and 47% were non-cereal breakfast consumers. Females were more likely to have a non-cereal breakfast than males, and the non-cereal breakfast was predominantly bread-based. Breakfast skipping decreased with age (p < 0.001), while breakfast cereal consumption increased with age (p < 0.001). Breakfast skippers were more likely to be male, had a lower socio-economic status, and lower physical activity levels (p < 0.001). Breakfast skippers had the highest mean body mass index (BMI) and waist circumference (p < 0.001), the lowest intake of wholegrain foods, fruits and vegetables, and the highest intake of discretionary foods (p < 0.001). Breakfast cereal consumers had the lowest mean BMI and waist circumference (p < 0.001) and had healthier diets at both breakfast and throughout the rest of the day. They were the most likely to meet the daily recommended serves for grain foods, fruit, dairy, and vegetables, had the highest wholegrain food intake, and the lowest discretionary intake (p < 0.001). Additionally, breakfast cereal consumers had the most favourable daily nutrient intakes, including the lowest added sugars intakes. Differences in daily diet between breakfast groups were attributed to differences in food choices both at breakfast and throughout the rest of the day.
YAP and TAZ Negatively Regulate Prox1 During Developmental and Pathologic Lymphangiogenesis

Rationale: The Hippo pathway governs cellular differentiation, morphogenesis, and homeostasis, but how it regulates these processes in lymphatic vessels is unknown. Objective: We aimed to reveal the role of the final effectors of the Hippo pathway, YAP (Yes-associated protein) and TAZ (transcriptional coactivator with PDZ-binding motif), in lymphatic endothelial cell (LEC) differentiation, morphogenesis, and homeostasis. Methods and Results: During mouse embryonic development, LEC-specific depletion of Yap/Taz disturbed both plexus patterning and valve initiation with upregulated Prox1 (prospero homeobox 1). Conversely, LEC-specific YAP/TAZ hyperactivation impaired lymphatic specification and restricted lymphatic sprouting with profoundly downregulated Prox1. Notably, lymphatic YAP/TAZ depletion or hyperactivation aggravated or attenuated pathological lymphangiogenesis in mouse cornea. Mechanistically, VEGF (vascular endothelial growth factor)-C activated canonical Hippo signaling pathway in LECs. Indeed, repression of PROX1 transcription by YAP/TAZ hyperactivation was mediated by recruitment of NuRD (nucleosome remodeling and histone deacetylase) complex and endogenous binding activity of TEAD (TEA domain family members) to the PROX1 promoter. Furthermore, YAP/TAZ hyperactivation enhanced MYC signaling and inhibited CDKN1C, leading to cell cycle dysregulation and aberrant proliferation. Conclusions: We find that YAP and TAZ play promoting roles in remodeling lymphatic plexus patterning and postnatal lymphatic valve maintenance by negatively regulating Prox1 expression. We further show that YAP and TAZ act as plastic regulators of lymphatic identity and define the Hippo signaling-mediated PROX1 transcriptional programing as a novel dynamic checkpoint underlying LEC plasticity and pathophysiology.
MicroRNAs mediate liver transcriptome changes upon soy diet intervention in mice

Soy‐based diets have triggered the interest of the research community due to their beneficial effects on a wide variety of pathologies like breast and prostate cancer, diabetes and atherosclerosis. However, the molecular details underlying these effects are far from being completely understood; several recent attempts have been made to elucidate the soy‐induced liver transcriptome changes in different animal models. Here we used Next Generation Sequencing to identify a set of microRNAs specifically modulated by short‐term soy‐enriched diet in young male mice and estimated their impact on the liver transcriptome assessed by microarray. Clustering and topological community detection (CTCD) network analysis of STRING generated interactions of transcriptome data led to the identification of four topological communities of genes characteristically altered and putatively targeted by microRNAs upon soy diet intervention.
OsSHOC1 and OsPTD1 are essential for crossover formation during rice meiosis

Meiosis is essential for eukaryotic sexual reproduction and plant fertility, and crossovers (COs) are essential for meiosis and the formation of new allelic combinations in gametes. In this study, we report the isolation of a meiotic gene, OsSHOC1, and the identification of its partner, OsPTD1. Osshoc1 was sterile both in male and female gametophytes, and it showed a striking reduction in the number of meiotic COs, indicating that OsSHOC1 was required for normal CO formation. Further investigations showed that OsSHOC1 physically interacted with OsPTD1 and that the latter was also required for normal CO formation and plant fertility. Additionally, the expression profiles of both genes were consistent with their functions. Our results suggest that OsSHOC1 and OsPTD1 are essential for rice fertility and CO formation, possibly by stabilizing the recombinant intermediates during meiosis.
Semi-Empirical Force-Field Model for the Ti1−xAlxN (0 ≤ x ≤ 1) System

We present a modified embedded atom method (MEAM) semi-empirical force-field model for the Ti1−xAlxN (0 ≤ x ≤ 1) alloy system. The MEAM parameters, determined via an adaptive simulated-annealing (ASA) minimization scheme, optimize the model’s predictions with respect to 0 K equilibrium volumes, elastic constants, cohesive energies, enthalpies of mixing, and point-defect formation energies, for a set of ≈40 elemental, binary, and ternary Ti-Al-N structures and configurations. Subsequently, the reliability of the model is thoroughly verified against known finite-temperature thermodynamic and kinetic properties of key binary Ti-N and Al-N phases, as well as properties of Ti1−xAlxN (0 < x < 1) alloys. The successful outcome of the validation underscores the transferability of our model, opening the way for large-scale molecular dynamics simulations of, e.g., phase evolution, interfacial processes, and mechanical response in Ti-Al-N-based alloys, superlattices, and nanostructures.
Nursing approaches in the postoperative pain management Ameliyat sonrasi ağri yönetiminde hemşirelik yaklaşimlari

Patients frequently experience moderate to severe pain in the postoperative period. Although the pain management is an integral and important part of the nursing care, studies suggest that, nursing management of postoperative pain remains inadequate. Postoperative care nurses are responsible to assess the patient’s pain, teach the patient strategies to deal with the pain, apply the analgesic treatment plan, monitor the results of treatment, educate the patient and the family on pain management and document the pain management outcomes. The nurses’ holistic approach to pain management minimizes the patients’ discomfort caused by pain in the postoperative period after the surgery. In this article, nurses’ approaches to postoperative pain management are discussed. J Clin Exp Invest 2011; 2 (4): 474-478
School Personnel Knowledge and Perceived Skills in Diabetic Emergencies in Georgia Public Schools

Diabetes affects tens of thousands of school-aged children in the United States. The ability to appropriately manage their diabetes is essential to preventing life-threatening health complications if occurring during the school day. The purpose of this study was to assess school personnel’s knowledge of diabetes (types 1 and 2) and perceived self-competence in performing diabetes management skills. A non-probability sample of elementary school personnel (N = 809) from five different school districts in Georgia completed a diabetes knowledge and competence questionnaire. Descriptive statistics, one-way analysis of variance, and principal component analysis were performed to analyze the data. School personnel reported limited knowledge of diabetes basics and an overall low perceived self-competence in performing many of the diabetic management skills. Despite state legislation enacted to assist children with diabetes in school and available training for school districts, the study found that school personnel are not well trained and lack confidence in performing diabetes management.
Hierarchical Features Driven Residual Learning for Depth Map Super-Resolution

Rapid development of affordable and portable consumer depth cameras facilitates the use of depth information in many computer vision tasks such as intelligent vehicles and 3D reconstruction. However, depth map captured by low-cost depth sensors (e.g., Kinect) usually suffers from low spatial resolution, which limits its potential applications. In this paper, we propose a novel deep network for depth map super-resolution (SR), called DepthSR-Net. The proposed DepthSR-Net automatically infers a high-resolution (HR) depth map from its low-resolution (LR) version by hierarchical features driven residual learning. Specifically, DepthSR-Net is built on residual U-Net deep network architecture. Given LR depth map, we first obtain the desired HR by bicubic interpolation upsampling and then construct an input pyramid to achieve multiple level receptive fields. Next, we extract hierarchical features from the input pyramid, intensity image, and encoder–decoder structure of U-Net. Finally, we learn the residual between the interpolated depth map and the corresponding HR one using the rich hierarchical features. The final HR depth map is achieved by adding the learned residual to the interpolated depth map. We conduct an ablation study to demonstrate the effectiveness of each component in the proposed network. Extensive experiments demonstrate that the proposed method outperforms the state-of-the-art methods. In addition, the potential usage of the proposed network in other low-level vision problems is discussed.
A Pilot Trial of the Combination of Transgenic NY-ESO-1–reactive Adoptive Cellular Therapy with Dendritic Cell Vaccination with or without Ipilimumab

Purpose: Transgenic adoptive cell therapy (ACT) targeting the tumor antigen NY-ESO-1 can be effective for the treatment of sarcoma and melanoma. Preclinical models have shown that this therapy can be improved with the addition of dendritic cell (DC) vaccination and immune checkpoint blockade. We studied the safety, feasibility, and antitumor efficacy of transgenic ACT with DC vaccination, with and without CTLA-4 blockade with ipilimumab. Patients and Methods: Freshly prepared autologous NY-ESO-1–specific T-cell receptor (TCR) transgenic lymphocytes were adoptively transferred together with NY-ESO-1 peptide-pulsed DC vaccination in HLA-A2.1–positive subjects alone (ESO, NCT02070406) or with ipilimumab (INY, NCT01697527) in patients with advanced sarcoma or melanoma. Results: Six patients were enrolled in the ESO cohort, and four were enrolled in the INY cohort. Four out of six patients treated per ESO (66%), and two out of four patients treated per INY (50%) displayed evidence of tumor regression. Peripheral blood reconstitution with NY-ESO-1–specific T cells peaked within 2 weeks of ACT, indicating rapid in vivo expansion. Tracking of transgenic T cells to the tumor sites was demonstrated in on-treatment biopsies via TCR sequencing. Multiparametric mass cytometry of transgenic cells demonstrated shifting of transgenic cells from memory phenotypes to more terminally differentiated effector phenotypes over time. Conclusions: ACT of fresh NY-ESO-1 transgenic T cells prepared via a short ex vivo protocol and given with DC vaccination, with or without ipilimumab, is feasible and results in transient antitumor activity, with no apparent clinical benefit of the addition of ipilimumab. Improvements are needed to maintain tumor responses.
A Multi-User Personal Indoor Localization System Employing Graph-Based Optimization

Personal indoor localization with smartphones is a well-researched area, with a number of approaches solving the problem separately for individual users. Most commonly, a particle filter is used to fuse information from dead reckoning and WiFi or Bluetooth adapters to provide an accurate location of the person holding a smartphone. Unfortunately, the existing solutions largely ignore the gains that emerge when a single localization system estimates locations of multiple users in the same environment. Approaches based on filtration maintain only estimates of the current poses of the users, marginalizing the historical data. Therefore, it is difficult to fuse data from multiple individual trajectories that are usually not perfectly synchronized in time. We propose a system that fuses the information from WiFi and dead reckoning employing the graph-based optimization, which is widely applied in robotics. The presented system can be used for localization of a single user, but the improvement is especially visible when this approach is extended to a multi-user scenario. The article presents a number of experiments performed with a smartphone inside an office building. These experiments demonstrate that graph-based optimization can be used as an efficient fusion mechanism to obtain accurate trajectory estimates both in the case of a single user and in a multi-user indoor localization system. The code of our system together with recorded dataset will be made available when the paper gets published.
Prevalence, Wellbeing, and Symptoms of Dysmenorrhea among University Nursing Students in Greece

Dysmenorrhea (pain during menstruation) is one of the most common medical conditions among women of reproductive age. Dysmenorrhea has been studied around the world but not yet in Greece. The aim of the present study was to investigate the prevalence, characteristics, and impact of dysmenorrhea on the wellbeing (exercising, and social and academic functioning) among nursing students in Greece. A cross-sectional study of 637 nursing students was conducted by administering a questionnaire at a university in Athens. The prevalence of dysmenorrhea was 89.2% and the rate of severe intensity was 52.5%. Factors that were associated with severe dysmenorrhea were family history (p = 0.02), early menarche (p = 0.05) and menstruation duration (p = 0.05). Women with moderate and severe pain reported using pain relievers (non-steroidal anti-inflammatory drugs (NSAIDs), paracetamol etc., p < 0.0005). Finally, activities affected by severe pain were class attendance (p = 0.01), personal studying (p < 0.0005), exercising (p < 0.0005), and socializing (p < 0.0005). Exam attendance (p = 0.27) and clinical placement attendance (p = 0.48) were not affected by severe dysmenorrhea. Dysmenorrhea has a high prevalence among nursing students and seems to affect important aspects of wellbeing and academic performance when the pain intensity is severe. The present findings lay the foundation for further investigation of dysmenorrhea both in the Greek population and cross-culturally.
Local Delivery of Brain-Derived Neurotrophic Factor Enables Behavioral Recovery and Tissue Repair in Stroke-Injured Rats.

IMPACT STATEMENT We developed a biocomposite that can be mixed with brain-derived neurotrophic factor (BDNF) and dispensed onto the surface of the brain to provide sustained, local release of the protein using a procedure that avoids additional damage to neural tissue. The composite is simple to fabricate, and provides sustained release without nanoparticle encapsulation of BDNF, preserving material and protein bioactivity. We demonstrate that when delivered epicortically to a rat model of stroke, this composite allows BDNF to diffuse into the brain, resulting in enhanced behavioral recovery and synaptic plasticity in the contralesional hemisphere.
Barriers of Reporting Errors among Nurses in a Tertiary Hospital

Background: Reporting errors in healthcare organizations is aimed to detect patient safety and quality of care issues. Reporting errors is frequently used as a general term for patient safety event reporting systems, which depend on those involved in events to provide detailed information. This study aimed to identify barriers of reporting errors at one tertiaryhospital in Saudi Arabia from the perspective of nurses themselves. Methodology: A descriptive cross-sectional study was conducted. The data were collected by a questionnaire that was distributed among 154 nurses varying between male and female staff nurses working at the tertiary hospital. A descriptive statistical analysis was used to analyze the data. Results: Nurses revealed that there are several barriers to report incidents; however, lack of time and complexity of works were the main barriers for nurses to report incidents within the hospital units particularly for nurses who have 11-20 years of experience. Conclusion: Conducting this study has several advantages. Firstly, to identify the common barriers of reporting errors in clinical practice among nurses. Secondly, identifying the barriers and strategies of reporting incidents will enhance the patient safety across the organization and encourage the staff to report the errors.