Miracle-dz/UniFAR-FTUs huggingface dataset:
Hypolipidemic and Antiatherogenic Effects of Aqueous Extract of Libyan Propolis in Lead Acetate Intoxicated Male Albino Mice

Hyperlipidemia is a major cause of atherosclerosis and atherosclerosis-associated conditions. Coronary artery disease is the epidemic of modern civilization in which dyslipidemia contributes significantly to its pathogenesis. Flavonoids and various phenolics are the most important pharmacologically active constituents in propolis capable of scavenging free radicals and thereby protecting lipids from being oxidized or destroyed during oxidative damage. The aim of this study was to investigate the hypolipidemic and antiatherogenic effects of aqueous extract of Libyan propolis in lead acetate intoxicated male albino mice. In this study, Thirty two adult male albino were used for this study and divided into four groups. The first group was control group, the 2nd was the propolis group orally received propolis (200 mg/kg body wt), the 3rd was the experimental and received lead acetate (500 mg /kg diet), the 4th one co-administered lead acetate (500 mg/kg diet) with propolis (200 mg/kg body wt)daily for 30 days. Blood samples were obtained for assessment of serum cholesterol, triglycerides, HDL, LDL, parameters. In lead treated animals, the serum cholesterol, triglycerides, HDLc, LDLc, VLDL, Castelli’s Risk Index I (TC/HDLc), Castelli’s Risk Index II (LDLc/HDLc), Atherogenic Coefficient {(TCHDLc)/HDLc } and Atherogenic Index of Plasma{ (AIP)= log(TG/HDLC)} parameters were increased and serum HDLc was decreased. Co-administration of propolis significantly improved of lipids profile parameters the ratios based on these parameters. Serum cholesterol, triglycerides, non HDLc, LDLc, VLDL, Castelli’s Risk Index I (TC/HDLc), Castelli’s Risk Index II (LDLc/HDLc), Atherogenic Coefficient {(TCHDLc)/HDLc } and Atherogenic Index of Plasma{ (AIP)= log(TG/HDLC)} parameters were significantly declined and serum HDLc was elevated. It can be concluded that, the lead had adverse effects on serum lipids profile parameters and the ratios based on these parameters. Propolis showed hypolipidemic and antiatherogenic effects in lead acetate intoxicated male albino mice. So, the populations of high risk to lead should be advised to take propolis.
Environmental Justice: A Panoptic Overview Using Scientometrics

Since its initial introduction in the 1970s, the field of environmental justice (EJ) continues to grow, with significant contributions from the disciplines of sustainability science, geography, political science, public policy and administration, urban planning, law, and many others. Each of these disciplines approach EJ research from slightly different perspectives, but all offer unique and valuable insight to the EJ knowledge domain. Although the interdisciplinary nature of environmental justice should be viewed as a strength, it presents a challenge when attempting to both summarize and synthesize key contributions to the field, due to disciplinary bias, narrow subfield foci, or gaps in knowledge by a research team without a representative disciplinary composition. The purpose of this paper is to provide a succinct, panoptic review of key research contributions to environmental justice, while simultaneously minimizing common problems associated with traditional reviews. In particular, this paper explores the utility of co-citation network analysis, to provide insight into the most important subdomains of environmental justice research. The results suggest that while early EJ research is initially focused on environmental disamenities and a continued focus on race and inequality, the research gradually shifts to foci more concerned with environmental amenities, such as parks and greenspace. We also find that race and inequality remain an important and consist line of research over the duration of the study time period. Implications for environmental justice research and its allied subfields are discussed.
Centrosome Linker–induced Tetraploid Segregation Errors Link Rhabdoid Phenotypes and Lethal Colorectal Cancers

Centrosome anomalies contribute to tumorigenesis, but it remains unclear how they are generated in lethal cancer phenotypes. Here, it is demonstrated that human microsatellite instable (MSI) and BRAFV600E-mutant colorectal cancers with a lethal rhabdoid phenotype are characterized by inactivation of centrosomal functions. A splice site mutation that causes an unbalanced dosage of rootletin (CROCC), a centrosome linker component required for centrosome cohesion and separation at the chromosome 1p36.13 locus, resulted in abnormally shaped centrosomes in rhabdoid cells from human colon tissues. Notably, deleterious deletions at 1p36.13 were recurrent in a subgroup of BRAFV600E-mutant and microsatellite stable (MSS) rhabdoid colorectal cancers, but not in classical colorectal cancer or pediatric rhabdoid tumors. Interfering with CROCC expression in near-diploid BRAFV600E-mutant/MSI colon cancer cells disrupts bipolar mitotic spindle architecture, promotes tetraploid segregation errors, resulting in a highly aggressive rhabdoid-like phenotype in vitro. Restoring near-wild-type levels of CROCC in a metastatic model harboring 1p36.13 deletion results in correction of centrosome segregation errors and cell death, revealing a mechanism of tolerance to mitotic errors and tetraploidization promoted by deleterious 1p36.13 loss. Accordingly, cancer cells lacking 1p36.13 display far greater sensitivity to centrosome spindle pole stabilizing agents in vitro. These data shed light on a previously unknown link between centrosome cohesion defects and lethal cancer phenotypes providing new insight into pathways underlying genome instability. Implications: Mis-segregation of chromosomes is a prominent feature of chromosome instability and intratumoral heterogeneity recurrent in metastatic tumors for which the molecular basis is unknown. This study provides insight into the mechanism by which defects in rootletin, a centrosome linker component causes tetraploid segregation errors and phenotypic transition to a clinically devastating form of malignant rhabdoid tumor. Mol Cancer Res; 16(9); 1385–95. ©2018 AACR.
Herd-level infectious disease surveillance of livestock populations using aggregate samples

Abstract All sectors of livestock production are in the process of shifting from small populations on many farms to large populations on fewer farms. A concurrent shift has occurred in the number of livestock moved across political boundaries. The unintended consequence of these changes has been the appearance of multifactorial diseases that are resistant to traditional methods of prevention and control. The need to understand complex animal health conditions mandates a shift toward the collection of longitudinal animal health data. Historically, collection of such data has frustrated and challenged animal health specialists. A promising trend in the evolution toward more efficient and effective livestock disease surveillance is the increased use of aggregate samples, e.g. bulk tank milk and oral fluid specimens. These sample types provide the means to monitor disease, estimate herd prevalence, and evaluate spatiotemporal trends in disease distribution. Thus, this article provides an overview of the use of bulk tank milk and pen-based oral fluids in the surveillance of livestock populations for infectious diseases.
Results with continuous cardiopulmonary bypass for the bidirectional cavopulmonary anastomosis*

Abstract Objective Some centres have proposed creating the bidirectional cavopulmonary anastomosis without cardiopulmonary bypass, while others continue to use deep hypothermic circulatory arrest. The purpose of this review is to evaluate the results of using continuous cardiopulmonary bypass with moderate hypothermia, perhaps the most commonly used of the three techniques for this procedure. Methods Between 1990 and 2005, 114 patients, having a mean age of 1.58 years, with a median age of 8 months, and ranging from 3 months to 16 years, underwent creation of either a unilateral cavopulmonary anastomosis, in 94 cases, or bilateral anastomoses in 20 cases. All had continuous cardiopulmonary bypass with moderate hypothermia at 32 degrees Celsius, with 24 also having aortic cross-clamping with cardioplegia for simultaneous intracardiac procedures. Interrupted absorbable sutures were used to create the anastomosis in 105 patients. Results Perioperative mortality was 5%, with 6 of the patients dying. The mean period of cardiopulmonary bypass for an isolated anastomosis was 91 minutes, with a range from 44 to 160 minutes. In 10 patients (8.8%), it was necessary to place a graft to augment the anastomosis. The average postoperative length of stay was 7.9 days for those undergoing an isolated unilateral anastomosis, and 16.4 days for patients undergoing combined cardiac operations. We have now created the Fontan circulation in 79 of the patients, at an average interval from the bidirectional cavopulmonary anastomosis of 2.1 plus or minus 1.14 years. In 76 patients, we performed postoperative angiograms, and none revealed any stenoses. Conclusions The bidirectional cavopulmonary anastomosis can be performed successfully with continuous cardiopulmonary bypass and moderate hypothermia with a beating heart, avoiding circulatory arrest. The use of interrupted and absorbable sutures was not associated with any late anastomotic stenosis.
A Comprehensive Characterization of a 10 at.% Yb:YSAG Laser Ceramic Sample

We report a comprehensive characterization of a 10 at. % Yb3+-doped YSAG (Yb:Y3ScxAl(5−x)O12, x = 1.5) ceramic, including microstructural, spectroscopic and laser properties. Moreover, we illustrate and discuss the fabrication technique. Yb3+ in YSAG features a broader absorption and emission band than in traditional YAG, which is advantageous for laser applications (i.e., tunable laser sources, ultrafast pulse generation). Pumping in a quasi continuous wave regime at 936 nm, the ceramic has shown good laser performance as the maximum output power was 6.3 W with a corresponding slope efficiency (ηs) of 67.8%. In continuous wave regime instead, the maximum output power was 5 W with ηs = 52.7%. The laser emission wavelengths in free running were λL = 1051 nm and λL = 1031 nm, depending on the output coupler transmission. Finally, by a tunable cavity we obtained laser emission spanning from 991.5 to 1073 nm, i.e., 81.5 nm, which is the broadest tuning range ever reported for this material, to the best of our knowledge.
Rituximab-mediated late-onset neutropenia in systemic lupus erythematosus – distinct roles of BAFF and APRIL

Objective Rituximab-mediated late-onset neutropenia (LON) has been described in various diseases. We investigated its occurrence, consequences and contributing factors in patients with systemic lupus erythematosus (SLE). Methods Rituximab-treated patients from the Karolinska University Hospital (n = 107) were surveyed. LON was defined as an absolute neutrophil count <1500 cells/μl, occurring four weeks to two years following rituximab treatment, or later during sustained B-cell depletion. Serum levels of B-cell-related cytokines and growth factors of the myeloid lineage were determined using enzyme-linked immunosorbent assay. Results Thirty-two patients (29.9%) developed LON after a median time of 201.5 days. Thirteen patients were admitted to the hospital; 10 due to fever. Three patients developed critical conditions. BAFF levels increased from baseline (median: 0.62 ng/ml) to the post-treatment evaluation (median: 1.16 ng/ml; p < 0.001); post-treatment levels were higher in the LON group (p = 0.021). APRIL levels were higher in the LON group both at baseline (median: 1.54 versus 1.15 ng/ml; p = 0.027) and post-treatment (median: 2.39 versus 1.11 ng/ml; p = 0.011). IL-6 and GM-CSF levels decreased in the non-LON group (p < 0.001), but not in LON patients. High baseline disease activity predicted LON development (OR: 4.1; 95% CI: 1.1–15.2 for SLEDAI-2K > 8). No association with neutropenia prior to rituximab treatment was documented. Conclusion Post-rituximab LON was a common complication. Although the phenomenon was predominantly self-limiting, several patients developed severe conditions. Distinct roles of BAFF and APRIL are implicated: BAFF may contribute to LON development, whereas high APRIL levels may be predictive. Rituximab-treated SLE patients should be monitored for neutrophil counts, fever and infections.
Parametric Dual Maximization for Non-Convex Learning Problems

We consider a class of non-convex learning problems that can be formulated as jointly optimizing regularized hinge loss and a set of auxiliary variables. Such problems encompass but are not limited to various versions of semi-supervised learning,learning with hidden structures, robust learning, etc. Existing methods either suffer from local minima or have to invoke anon-scalable combinatorial search. In this paper, we propose a novel learning procedure, namely Parametric Dual Maximization(PDM), that can approach global optimality efficiently with user specified approximation levels. The building blocks of PDM are two new results: (1) The equivalent convex maximization reformulation derived by parametric analysis. (2) The improvement of local solutions based on a necessary and sufficient condition for global optimality. Experimental results on two representative applications demonstrate the effectiveness of PDM compared to other approaches.
RGB-Depth SLAM Review

Simultaneous Localization and Mapping (SLAM) have made the real-time dense reconstruction possible increasing the prospects of navigation, tracking, and augmented reality problems. Some breakthroughs have been achieved in this regard during past few decades and more remarkable works are still going on. This paper presents an overview of SLAM approaches that have been developed till now. Kinect Fusion algorithm, its variants, and further developed approaches are discussed in detailed. The algorithms and approaches are compared for their effectiveness in tracking and mapping based on Root Mean Square error over online available datasets.
d-Amino Acid Peptide Residualizing Agents for Protein Radioiodination: Effect of Aspartate for Glutamate Substitution

The residualizing prosthetic agent Nε-(3-[*I]iodobenzoyl)-Lys5-Nα-maleimido-Gly1-d-GEEEK ([*I]IB-Mal-d-GEEEK) showed promise for the radioiodination of monoclonal antibodies (mAbs) that bind to internalizing molecular targets. Although enhanced tumor uptake was achieved in these studies, elevated kidney accumulation also was observed, particularly with low-molecular-weight, single-domain antibody fragments (sdAbs). Here, we developed an analogous agent (IB-Mal-d-GDDDK), in which glutamate residues (E) were replaced with aspartates (D) to determine whether this modification could decrease renal uptake. [125I]IB-Mal-d-GDDDK and [131I]IB-Mal-d-GEEEK were synthesized with similar radiochemical yields (60–80%) and coupled to the anti-HER2 sdAb 5F7 at 50–60% efficiency. Paired-label internalization assays in vitro indicated similar levels of intracellular activity residualization in HER2-expressing BT474M1 cells for [125I]IB-Mal-d-GDDDK-5F7 and [131I]IB-Mal-d-GEEEK-5F7. A paired-label biodistribution comparison of the two labeled conjugates was performed in mice with HER2-expressing SKOV-3 xenografts, and the results of this study indicated that renal uptake at 1 h was 127.5 ± 18.7% ID/g and 271.4 ± 66.6% ID/g for [125I]IB-Mal-d-GDDDK-5F7 and [131I]IB-Mal-d-GEEEK-5F7, respectively. The tumor uptake of the two radioconjugates was not significantly different. These results demonstrate that substitution of E with D in the IB-Mal-d-GEEEK construct reduced kidney accumulation of the sdAb. However, renal activity levels need to be reduced further if d-amino acid derived prosthetic agents are to be of practical value for labeling low molecular weight biomolecules such as sdAbs.
Type and Location of Wearable Sensors for Monitoring Falls during Static and Dynamic Tasks in Healthy Elderly: A Review

In recent years, the meaning of successful living has moved from extending lifetime to improving the quality of aging, mainly in terms of high cognitive and physical functioning together with avoiding diseases. In healthy elderly, falls represent an alarming accident both in terms of number of events and the consequent decrease in the quality of life. Stability control is a key approach for studying the genesis of falls, for detecting the event and trying to develop methodologies to prevent it. Wearable sensors have proved to be very useful in monitoring and analyzing the stability of subjects. Within this manuscript, a review of the approaches proposed in the literature for fall risk assessment, fall prevention and fall detection in healthy elderly is provided. The review has been carried out by using the most adopted publication databases and by defining a search strategy based on keywords and boolean algebra constructs. The analysis aims at evaluating the state of the art of such kind of monitoring, both in terms of most adopted sensor technologies and of their location on the human body. The review has been extended to both dynamic and static analyses. In order to provide a useful tool for researchers involved in this field, the manuscript also focuses on the tests conducted in the analyzed studies, mainly in terms of characteristics of the population involved and of the tasks used. Finally, the main trends related to sensor typology, sensor location and tasks have been identified.
Autophagy as a Possible Target for Cancer Therapy

Autophagy is an evolutionarily conserved catabolic process that targets cellular organelles and cytoplasmic constituents to the lysosomes for degradation. According to the type of cargo delivery, there are three main types of autophagy systems in mammals: macroautophagy, microautophagy, and chaperone-mediated autophagy. Macroautophagy, often simply (and hereafter) referred to as autophagy, is the best studied autophagic process and focus of this review. Autophagy has been recognized to be a pro-survival mechanism at times of cellular stress including starvation. Besides, increasing evidence indicated the importance of autophagy in in the pathogenesis of several diseases including cancer. But, its role in cancer is more complex and still controversial; it appears to be tumor suppressive during tumorigenesis, but contributes to tumor cell survival during cancer progression. Besides, autophagic capacity was shown to significantly affect responses of cancer cells to anticancer agents and radiation. Even though there is still a gap about how autophagy is regulated in cancer, it appears to provide a promising target for cancer treatment. This review aimed at examining the multiple roles of autophagy as a novel target for cancer therapy.
Dietary calcium concentration and cereals differentially affect mineral balance and tight junction proteins expression in jejunum of weaned pigs

Ca plays an essential role in bone development; however, little is known about its effect on intestinal gene expression in juvenile animals. In the present study, thirty-two weaned pigs (9·5 (sem 0·11) kg) were assigned to four diets that differed in Ca concentration (adequate v. high) and cereal composition (wheat–barley v. maize) to assess the jejunal and colonic gene expression of nutrient transporters, tight junction proteins, cytokines and pathogen-associated molecular patterns, nutrient digestibility, Ca balance and serum acute-phase response. To estimate the impact of mucosal bacteria on colonic gene expression, Spearman's correlations between colonic gene expression and bacterial abundance were computed. Faecal Ca excretion indicated that more Ca was available along the intestinal tract of the pigs fed high Ca diets as compared to the pigs fed adequate Ca diets (P< 0·05). High Ca diets decreased jejunal zonula occludens 1 (ZO1) and occludin (OCLN) expression, up-regulated jejunal expression of toll-like receptor 2 (TLR2) and down-regulated colonic GLUT2 expression as compared to the adequate Ca diets (P< 0·05). Dietary cereal composition up-regulated jejunal TLR2 expression and interacted (P= 0·021) with dietary Ca on colonic IL1B expression; high Ca concentration up-regulated IL1B expression with wheat–barley diets and down-regulated it with maize diets. Spearman's correlations (r>0·35; P< 0·05) indicated an association between operational taxonomic units assigned to the phyla Bacteroidetes, Firmicutes and Proteobacteria and bacterial metabolites and mucosal gene expression in the colon. The present results indicate that high Ca diets have the potential to modify the jejunal and colonic mucosal gene expression response which, in turn, interacts with the composition of the basal diet and mucosa-associated bacteria in weaned pigs.
Derivative estimation for longitudinal data analysis: Examining features of blood pressure measured repeatedly during pregnancy

Estimating velocity and acceleration trajectories allows novel inferences in the field of longitudinal data analysis, such as estimating change regions rather than change points, and testing group effects on nonlinear change in an outcome (ie, a nonlinear interaction). In this article, we develop derivative estimation for 2 standard approaches—polynomial mixed models and spline mixed models. We compare their performance with an established method—principal component analysis through conditional expectation through a simulation study. We then apply the methods to repeated blood pressure (BP) measurements in a UK cohort of pregnant women, where the goals of analysis are to (i) identify and estimate regions of BP change for each individual and (ii) investigate the association between parity and BP change at the population level. The penalized spline mixed model had the lowest bias in our simulation study, and we identified evidence for BP change regions in over 75% of pregnant women. Using mean velocity difference revealed differences in BP change between women in their first pregnancy compared with those who had at least 1 previous pregnancy. We recommend the use of penalized spline mixed models for derivative estimation in longitudinal data analysis.
An improved north–south synchronization of ice core records around the 41 kyr 10 Be peak

Abstract. Using new high-resolution 10Be measurements in the NGRIP, EDML and Vostok ice cores, together with previously published data from EDC, we present an improved synchronization between Greenland and Antarctic ice cores during the Laschamp geomagnetic excursion ∼ 41 kyr ago. We estimate the precision of this synchronization to be ±20 years, an order of magnitude better than previous work. We discuss the implications of this new synchronization for making improved estimates of the depth difference between ice and enclosed gas of the same age (Δdepth), difference between age of ice and enclosed gas at the same depth (Δage) in the EDC and EDML ice cores, spectral properties of the 10Be profiles and phasing between Dansgaard–Oeschger-10 (in NGRIP) and AIM-10 (in EDML and EDC).
Diverse Few-Shot Text Classification with Multiple Metrics

We study few-shot learning in natural language domains. Compared to many existing works that apply either metric-based or optimization-based meta-learning to image domain with low inter-task variance, we consider a more realistic setting, where tasks are diverse. However, it imposes tremendous difficulties to existing state-of-the-art metric-based algorithms since a single metric is insufficient to capture complex task variations in natural language domain. To alleviate the problem, we propose an adaptive metric learning approach that automatically determines the best weighted combination from a set of metrics obtained from meta-training tasks for a newly seen few-shot task. Extensive quantitative evaluations on real-world sentiment analysis and dialog intent classification datasets demonstrate that the proposed method performs favorably against state-of-the-art few shot learning algorithms in terms of predictive accuracy. We make our code and data available for further study.