Miracle-dz/UniFAR-FTUs huggingface dataset:
Visual Acuity Is Not the Best at the Preferred Retinal Locus in People with Macular Disease.

SIGNIFICANCE Little is known about how the preferred retinal locus (PRL) develops in patients with macular disease. We found that acuity is worse at the PRL than at other retinal locations around the scotoma, suggesting that the selection of the PRL location is unlikely to be based on optimizing acuity. PURPOSE Following the onset of bilateral macular disease, most patients adopt a retinal location outside the central scotoma, the PRL, as their new retinal location for visual tasks. Very little information is known about how the location of a PRL is chosen. In this study, we tested the hypothesis that the selection of the location for a PRL is based on optimizing visual acuity, which predicts that acuity is the best at the PRL, compared with other retinal locations. METHODS Using a scanning laser ophthalmoscope that allowed us to position visual targets at precise retinal locations, we measured acuity psychophysically using a four-orientation Tumbling-E presented at the PRL and at multiple (ranged between 23 and 36 across observers) locations around the scotoma for five observers with bilateral macular disease. RESULTS For all five observers, the acuity at the PRL was never the best among all testing locations. Instead, acuities were better at 15 to 86% of the testing locations other than the PRL, with the best acuity being 17 to 58% better than that at the PRL. The locations with better acuities did not cluster around the PRL and did not necessarily lie at the same distance from the fovea or the PRL. CONCLUSIONS Our finding that acuity is worse at the PRL than at other locations around the scotoma implies that the selection of the PRL location is unlikely to be based on optimizing acuity.
Estimation of mortality from orphanhood in adulthood

This paper extends earlier research into methods for estimating adult mortality from information on the recent incidence of orphanhood. It presents a series of regression coefficients for estimating female and male mortality from synthetic cohort data on the subsequent orphanhood of those who had a living mother or father at exact age 20. Such information can be obtained either where questions about parental survival have been asked in two inquiries or by asking retrospectively about dates of orphanhood in a single survey. Although the method is somewhat sensitive to errors in the reporting of ages and dates, it is a promising source of up-to-date estimates of adult mortality that are free from bias due to the underreporting of the orphanhood of young children (“the adoption effect”).
Dust emission in star-forming dwarf galaxies: General properties and the nature of the sub-mm excess

We studied the global characteristics of dust emission in a large sample of emission-line star-forming galaxies. The sample consists of two subsamples. One subsample (SDSS sample) includes ~4000 compact star-forming galaxies from the SDSS, which were also detected in all four bands at 3.4, 4.6, 12, and 22 mum of the WISE all-sky survey. The second subsample (Herschel sample) is a sample of 28 compact star-forming galaxies observed with Herschel in the FIR range. Data of the Herschel sample were supplemented by the photometric data from the Spitzer observations, GALEX, SDSS, WISE, 2MASS, NVSS, and FIRST surveys, as well as optical and Spitzer spectra and data in sub-mm and radio ranges. It is found that warm dust luminosities of galaxies from the SDSS sample and cold and warm dust luminosities of galaxies from the Herschel sample are strongly correlated with Hbeta luminosities, which implies that one of the main sources of dust heating in star-forming galaxies is ionising UV radiation of young stars. Using the relation between warm and cold dust masses for estimating the total dust mass in star-forming galaxies with an accuracy better than ~0.5 dex is proposed. On the other hand, it is shown for both samples that dust temperatures do not depend on the metallicities. The dust-to-neutral gas mass ratio strongly declines with decreasing metallicity, similar to that found in other studies of local emission-line galaxies, high-redshift GRB hosts, and DLAs. On the other hand, the dust-to-ionised gas mass ratio is about one hundred times as high implying that most of dust is located in the neutral gas. It is found that thermal free-free emission of ionised gas in compact star-forming galaxies might be responsible for the sub-mm emission excess. This effect is stronger in galaxies with lower metallicities and is also positively affected by an increased star-formation rate.
MiRNA-155 Regulates the Th17/Treg Ratio by Targeting SOCS1 in Severe Acute Pancreatitis

Acute pancreatitis (AP) is a serious condition associated with intestinal barrier disruption or inflammation of the pancreatic tissue. Specific microRNAs are involved in the pathogenesis of AP, during which IL-17-producing CD4+ T helper (Th17) cells accumulate in the pancreas. In this study, significantly increased levels of miR-155 were detected in clinical samples from patients with AP, and overexpression of miR-155 correlated with severe AP (SAP). To identify the effect of miR-155 on T cell differentiation, we isolated CD4+ T lymphocytes and in vitro experiments showed that inhibition of miR-155 significantly reversed the stress-induced increase in the Th17/Treg ratio. The results also showed that miR-155 increased the Th17-mediated inflammatory response by targeting SOCS1. The interaction between miR-155 and the 3′-UTR of SOCS1 was confirmed by a dual luciferase reporter assay and RT-PCR. Experimental AP of varying severity was induced in BALB/c mice by caerulein hyperstimulation and miR-155 expression was found to increase with disease progression. Inhibition of miR-155 expression significantly improved the pathology of the pancreas. We also observed downregulation of expression of inflammatory factors, IL-17, SOCS1 and phosphorylated STAT1 after miR-155 inhibition. In summary, miR-155 regulates the Th17/Treg ratio by targeting SOCS1, most probably via direct binding to its 3′-UTR region, indicating that this microRNA may be a potential biomarker and/or therapeutic target for AP.
Improving Communication and Load Balancing with Thread Mapping in Manycore Systems

Communication and load balancing have a significant impact on the performance of parallel applications and have been the subject of extensive research in multicore architectures. Thread mapping has been one of the solutions adopted in multicore architectures to address both communication and load balancing. However, the impact of such issues on more recently introduced manycore architectures is still unknown. Most related work on manycore architectures focus on execution time and idleness information for scheduling decisions. In this paper, we improve the state of the art by performing a very detailed analysis of the impact of thread mapping on communication and load balancing in two manycore systems from Intel, namely Knights Corner and Knights Landing. We observed that the widely used metric of CPU time provides very inaccurate information for load balancing. We also evaluated the usage of thread mapping based on the communication and load information of the applications to improve the performance of manycore systems.
Curcumin attenuates hepatic fibrosis and insulin resistance induced by bile duct ligation in rats

Abstract Recent studies have strongly indicated the hepatoprotective effect of curcumin; however, the precise mechanisms are not well understood. This study aimed to determine the protective effect of curcumin on hepatic damage and hepatic insulin resistance in biliary duct ligated (BDL) fibrotic rat model. To accomplish this, male Wistar rats were divided into four groups (eight for each): sham group, BDL group, sham+Cur group and BDL+Cur group. The last two groups received curcumin at a dose of 100 mg/kg daily for 4 weeks. The mRNA/protein expression levels of Ras-related C3 botulinum toxin substrate 1 (Rac1), Rac1-GTP, dinucleotide phosphate oxidase 1 (NOX1), signal transducer and activator of transcription 3 (STAT3), suppressor of cytokine signalling 3 (SOCS3), insulin receptor substrate 1 (IRS1), extracellular signal-regulated kinase 1 (ERK1), specific protein 1 (Sp1) and hypoxia-inducible factor-1α (HIF-1α) were measured by real-time PCR and Western blotting, respectively. Fasting blood glucose, insulin and Leptin levels were determined and homoeostasis model assessment-estimated insulin resistance, as an index of insulin resistance, was calculated. Curcumin significantly attenuated liver injury and fibrosis, including amelioration of liver histological changes, reduction of hepatic enzymes, as well as decreased expression of liver fibrogenesis-associated variables, including Rac1, Rac1-GTP, NOX1, ERK1, HIF-1α and Sp1. Curcumin also attenuated leptin level and insulin resistance, which had increased in BDL rats (P<0·05). Furthermore, compared with the BDL group, we observed an increase in IRS1 and a decrease in SOCS3 and STAT3 expression in the curcumin-treated BDL group (P<0·05), indicating return of these parameters towards normalcy. In conclusion, Curcumin showed hepatoprotective activity against BDL-induced liver injury and hepatic insulin resistance by influencing the expression of some genes/proteins involved in these processes, and the results suggest that it can be used as a therapeutic option.
Compound semiconductor alloys: From atomic-scale structure to bandgap bowing

Compound semiconductor alloys such as InxGa1−xAs, GaAsxP1−x, or CuInxGa1−xSe2 are increasingly employed in numerous electronic, optoelectronic, and photonic devices due to the possibility of tuning their properties over a wide parameter range simply by adjusting the alloy composition. Interestingly, the material properties are also determined by the atomic-scale structure of the alloys on the subnanometer scale. These local atomic arrangements exhibit a striking deviation from the average crystallographic structure featuring different element-specific bond lengths, pronounced bond angle relaxation and severe atomic displacements. The latter, in particular, have a strong influence on the bandgap energy and give rise to a significant contribution to the experimentally observed bandgap bowing. This article therefore reviews experimental and theoretical studies of the atomic-scale structure of III-V and II-VI zincblende alloys and I-III-VI2 chalcopyrite alloys and explains the characteristic findings in terms.
The Relative Contribution of Management Skills to Entrepreneurial Success: A Survey of Small and Medium Enterprises (SMEs) in the Trade Sector

Studies have shown that SMEs focus on management skills to ensure a long run performance of their firms. Thus, owing to the increase in SMEs in the trade sector in Makurdi town, Benue State, this study examined the relative contribution of management skills to the success of these SMEs. A survey research method was adopted for the study, while systematic sampling technique was employed to gather data using questionnaires. The generated data were analysed using Principal Component Analysis (PCA) and regression analysis. It was found that the highest relative contribution was made by skills for planning and budgeting for a marketing strategy that provides attractive range of products, followed by skills to act quickly on detecting changes in the environment, skills for assessing sales problems as a way of maintaining good customer relations, skills to focus on product quality so as to capture a sizeable market share, and management expertise skills to attract and keep competent employees. The study recommends that trade entrepreneurs should be sensitized to concentrate on learning and developing the identified skills.
Effect of the exhaust gas recirculation ratio and the energy share of the gaseous fuel on basic operating parameters and exhaust emissions in a dual-fuel compression ignition engine operating on natural gas

For many years in the Department of Automobiles and Internal Combustion Engines at Kazimierz Pulaski University of Technology and Humanities in Radom there are carried out investigations on dual-fuel combustion system in a compression ignition engine. The majority of literature reviews, as well as the authors' studies were limited to the older generation engines, i.e. naturally aspirated engines that are not equipped with the exhaust gas recirculation system. The paper presents results of investigations on a turbocharged engine equipped with an EGR system. The authors tried to assess the effect of the recirculation ratio on engine performances (mainly the mean effective pressure and the engine overall efficiency as well as exhaust emissions). The obtained results indicate that it is possible to apply high energy shares of the gaseous fuel maintaining at the same time high engine overall efficiency and visibly reducing the particulate matter emission. It was also noticed that the NOx emission may be visibly reduced introducing the exhaust gas recirculation system. Unfortunately, an increase of the gaseous fuel energy share results in slightly higher hydrocarbon and carbon monoxide emissions.
The Global Ocean Data Assimilation Experiment High-resolution Sea Surface Temperature Pilot Project

A new generation of integrated sea surface temperature (SST) data products are being provided by the Global Ocean Data Assimilation Experiment (GODAE) High-Resolution SST Pilot Project (GHRSST-PP). These combine in near-real time various SST data products from several different satellite sensors and in situ observations and maintain the fine spatial and temporal resolution needed by SST inputs to operational models. The practical realization of such an approach is complicated by the characteristic differences that exist between measurements of SST obtained from subsurface in-water sensors, and satellite microwave and satellite infrared radiometer systems. Furthermore, diurnal variability of SST within a 24-h period, manifested as both warm-layer and cool-skin deviations, introduces additional uncertainty for direct intercomparison between data sources and the implementation of data-merging strategies. The GHRSST-PP has developed and now operates an internationally distributed system that provides operatio.
Identifying a Core Domain Set to Assess Psoriasis in Clinical Trials

Importance There is no consensus on which domains should be measured or which instruments should be used in clinical trials for psoriasis therapies. Objective To achieve international consensus among psoriasis stakeholders on a core set of domains that should be measured in all psoriasis clinical trials. Design, Setting, and Participants Literature review, pre-Delphi survey exercises, nominal group discussions, and audience voting at 4 stakeholder meetings were used to develop candidate domains for 2 rounds of a Delphi survey. Stakeholders were patients or advocates of patients with psoriasis and health care professionals (HCPs) with expertise in psoriasis, including physicians, scientists, advocacy organization representatives, and regulators. Delphi surveys were conducted electronically from October through December 2015 and between September and October 2016. Stakeholder discussions with audience response voting were conducted at live meetings in the United States, Canada, and Italy from January 2013 to December 2016 to refine and ratify the core set of domains. Main Outcomes and Measures Two rounds of an electronic Delphi survey were used to determine consensus. A domain was considered “core” (ie, should be measured in all trials) if a threshold consensus of at least 70% was met in both patient and HCP groups. Domains meeting consensus in only 1 group were considered to be important but were not required to be measured in all trials (“middle ring”). These domains were included for rerating in round 2. Domains that did not meet consensus in either of the groups (“outer ring”) were considered to be of uncertain importance and were placed in the research agenda. Results In round 1 of the Delphi survey, 107 HCPs and 14 patients participated. Most HCPs (72 [67%]) were dermatologists between 46 and 64 years old (71 [66%]), white (78 [73%]), and male (75 [70%]) from North America (60 [57%]) and Europe (34 [32%]). There were 10 pharmaceutical industry clinical or health economic scientists, 3 advocacy organization representatives, 2 regulatory agency representatives, and 5 “other. ” In the second round, 77 HCPs and 15 patients participated. Of the 20 candidate domains, the following 6 met consensus as core domains: skin manifestations, psoriasis and psoriatic arthritis symptoms, health-related quality of life, investigator global assessment, patient global assessment, and treatment satisfaction. Secondary skin manifestations as well as nail, inverse, genital, and guttate psoriasis were classified as important but not mandatory. Psoriatic arthritis signs, work productivity or participation, economic impact (direct and indirect cost), and cardiovascular disease comprised the research agenda. Conclusions and Relevance This iterative Delphi process yielded international consensus among professional and patient stakeholders on 6 domains that should be measured in all clinical trials for psoriasis. Future International Dermatology Outcome Measures group efforts will focus on development of a core outcome measurement set for psoriasis trials.
An Automatic Segmentation Algorithm for Solar Filaments in H-Alpha Images using a Context-based Sliding Window

There are many features which appear on the surface of the sun. One of these features that appear clearly are the dark threads in the Hydrogen alpha (Hα) spectrum solar images. These ‘filaments’ are found to have a definite correlation with Coronal Mass Ejections (CMEs). A CME is a large release of plasma into space. It can be hazardous to astronauts and the spacecraft if it is being ejected towards the Earth. Knowing the exact attributes of solar filaments may open the way towards predicting the occurrence of CMEs. In this paper, an efficient and fully automated algorithm for solar filament segmentation without compromising accuracy is proposed. The algorithm uses some statistical measures to design the thresholding equations and it is written in the C++ programming language. The square root of the range as a measure of variability of image intensity values is used to determine the size of the sliding window at run time. There are many previous studies in this area, but no single segmentation method that could precisely claim to be fully automatic exists. Samples were taken from several representative regions in low-contrast and high-contrast solar images to verify the viability and efficacy of the method.
Exact Low Tubal Rank Tensor Recovery from Gaussian Measurements

The recent proposed Tensor Nuclear Norm (TNN) [Lu et al., 2016; 2018a] is an interesting convex penalty induced by the tensor SVD [Kilmer and Martin, 2011]. It plays a similar role as the matrix nuclear norm which is the convex surrogate of the matrix rank. Considering that the TNN based Tensor Robust PCA [Lu et al., 2018a] is an elegant extension of Robust PCA with a similar tight recovery bound, it is natural to solve other low rank tensor recovery problems extended from the matrix cases. However, the extensions and proofs are generally tedious. The general atomic norm provides a unified view of low-complexity structures induced norms, e.g., the l1-norm and nuclear norm. The sharp estimates of the required number of generic measurements for exact recovery based on the atomic norm are known in the literature. In this work, with a careful choice of the atomic set, we prove that TNN is a special atomic norm. Then by computing the Gaussian width of certain cone which is necessary for the sharp estimate, we achieve a simple bound for guaranteed low tubal rank tensor recovery from Gaussian measurements. Specifically, we show that by solving a TNN minimization problem, the underlying tensor of size n1×n2×n3 with tubal rank r can be exactly recovered when the given number of Gaussian measurements is O(r(n1+n2−r)n3). It is order optimal when comparing with the degrees of freedom r(n1+n2−r)n3. Beyond the Gaussian mapping, we also give the recovery guarantee of tensor completion based on the uniform random mapping by TNN minimization. Numerical experiments verify our theoretical results.
A Quality-of-Experience Database for Adaptive Video Streaming

The dynamic adaptive streaming over HTTP provides an inter-operable solution to overcome the volatile network conditions, but its complex characteristic brings new challenges to objective video quality-of-experience (QoE) measurement. To test the generalizability and to facilitate the wide usage of QoE measurement techniques in real-world applications, we establish a new database named Waterloo Streaming QoE Database III (SQoE-III). Unlike existing databases constructed with hand-crafted test sequences, the SQoE-III database, so far the largest and most realistic of its kind, consists of a total of 450 streaming videos created from diverse source content and diverse distortion patterns, with six adaptation algorithms of diverse characteristics under 13 representative network conditions. All streaming videos are assessed by 34 subjects, and a comprehensive evaluation is conducted on the performance of 15 objective QoE models from four categories with regards to their efficacy in predicting subjective QoE. Detailed correlation analysis and statistical hypothesis testing are carried out. The results of this paper shed light on the future development of adaptive bitrate streaming algorithm and video QoE monitoring system. The subjective database is available online at https://ece.uwaterloo. ca/~zduanmu/tbc2018qoe/.
De novo mutation screening in childhood-onset cerebellar atrophy identifies gain-of-function mutations in the CACNA1G calcium channel gene

Cerebellar atrophy is a key neuroradiological finding usually associated with cerebellar ataxia and cognitive development defect in children. Unlike the adult forms, early onset cerebellar atrophies are classically described as mostly autosomal recessive conditions and the exact contribution of de novo mutations to this phenotype has not been assessed. In contrast, recent studies pinpoint the high prevalence of pathogenic de novo mutations in other developmental disorders such as intellectual disability, autism spectrum disorders and epilepsy. Here, we investigated a cohort of 47 patients with early onset cerebellar atrophy and/or hypoplasia using a custom gene panel as well as whole exome sequencing. De novo mutations were identified in 35% of patients while 27% had mutations inherited in an autosomal recessive manner. Understanding if these de novo events act through a loss or a gain of function effect is critical for treatment considerations. To gain a better insight into the disease mechanisms causing these cerebellar defects, we focused on CACNA1G, a gene not yet associated with the early-onset form. This gene encodes the Cav3.1 subunit of T-type calcium channels highly expressed in Purkinje neurons and deep cerebellar nuclei. We identified four patients with de novo CACNA1G mutations. They all display severe motor and cognitive impairment, cerebellar atrophy as well as variable features such as facial dysmorphisms, digital anomalies, microcephaly and epilepsy. Three subjects share a recurrent c.2881G>A/p.Ala961Thr variant while the fourth patient has the c.4591A>G/p.Met1531Val variant. Both mutations drastically impaired channel inactivation properties with significantly slower kinetics (∼5 times) and negatively shifted potential for half-inactivation (>10 mV). In addition, these two mutations increase neuronal firing in a cerebellar nuclear neuron model and promote a larger window current fully inhibited by TTA-P2, a selective T-type channel blocker. This study highlights the prevalence of de novo mutations in early-onset cerebellar atrophy and demonstrates that A961T and M1531V are gain of function mutations. Moreover, it reveals that aberrant activity of Cav3.1 channels can markedly alter brain development and suggests that this condition could be amenable to treatment.