Miracle-dz/UniFAR-FTUs huggingface dataset:
Neuronal Kmt2a/Mll1 Histone Methyltransferase Is Essential for Prefrontal Synaptic Plasticity and Working Memory

Neuronal histone H3-lysine 4 methylation landscapes are defined by sharp peaks at gene promoters and other cis-regulatory sequences, but molecular and cellular phenotypes after neuron-specific deletion of H3K4 methyl-regulators remain largely unexplored. We report that neuronal ablation of the H3K4-specific methyltransferase, Kmt2a/Mixed-lineage leukemia 1 (Mll1), in mouse postnatal forebrain and adult prefrontal cortex (PFC) is associated with increased anxiety and robust cognitive deficits without locomotor dysfunction. In contrast, only mild behavioral phenotypes were observed after ablation of the Mll1 ortholog Kmt2b/Mll2 in PFC. Impaired working memory after Kmt2a/Mll1 ablation in PFC neurons was associated with loss of training-induced transient waves of Arc immediate early gene expression critical for synaptic plasticity. Medial prefrontal layer V pyramidal neurons, a major output relay of the cortex, demonstrated severely impaired synaptic facilitation and temporal summation, two forms of short-term plasticity essential for working memory. Chromatin immunoprecipitation followed by deep sequencing in Mll1-deficient cortical neurons revealed downregulated expression and loss of the transcriptional mark, trimethyl-H3K4, at <50 loci, including the homeodomain transcription factor Meis2. Small RNA-mediated Meis2 knockdown in PFC was associated with working memory defects similar to those elicited by Mll1 deletion. Therefore, mature prefrontal neurons critically depend on maintenance of Mll1-regulated H3K4 methylation at a subset of genes with an essential role in cognition and emotion.
Venous architecture of cerebral hemispheric white matter and comments on pathogenesis of medullary venous and other cerebral vascular malformations.

The parenchymal veins, especially the deep medullary veins, of the cerebral hemispheres were studied in detail by analyzing the stereoroentgenograms of multiple brain slices of postmortem injected brain specimens (injected into the internal carotid arteries in 17 cases and into the jugular veins in 12 cases). The presence of four zones--the first (or outer), the second (or candelabra), the third (or palmate) and the fourth (or subependymal) zone--of venous convergence was confirmed within the centrum semiovale, particularly in the frontoparietal area. Other venous convergences such as those related to the optic radiation in the para-atrial area were also found. Arterial branching zones were also observed in the areas similar to those of the medullary veins. It appears that these converging zones are created by rapidly growing crossing nerve fiber tracts, i.e., projection, commissural, and association fibers which grow rapidly during intrauterine and postnatal life. Pathogenesis of medullary venous malformation is also discussed from anatomical viewpoint, venoarchitecture of the pial, parenchymal, and subependymal veins and of the dural venous sinuses. The possibility of a similar mechanism (partial, mild, repetitive venoocclusive disease developing over a long period with fluctuating venous pressure) leading to formation of most (if not all) cases of medullary venous malformation and in some, if not many, cases of cerebral vascular malformations [aside from gene abnormality (chromosome 7) in familial cavernous angiomatosis, particularly in Hispanic American or other familial hereditary conditions] has been postulated.
Respiration-phase-matched digital tomosynthesis imaging for moving target verification: a feasibility study.

PURPOSE To develop a respiration-phase-matched digital tomosynthesis (DTS) technique to monitor moving targets, and to evaluate its accuracy for various imaging parameters and anatomical characteristics. METHODS Previously developed 3D-DTS techniques, registering onboard DTS (OB-DTS, reconstructed from onboard projections) to reference DTS (R-DTS, reconstructed from DRRs of 3D reference CT), are inadequate to monitor moving targets. The authors' proposed respiration-phase-matched DTS technique registers OB-DTS to R-DTS reconstructed from DRRs generated by the same phase images of 4D reference CT as the corresponding onboard projections. To evaluate the improved accuracy of the author's technique, the authors performed thoracic phantom studies using (1) simulation with the 4D digital extended-cardiac-torso (XCAT) phantom, and (2) experiments with an anthropomorphic motion phantom. The studies were performed for various: respiratory cycle (RC), scan angle, and fraction of RC contained therein. Also, the authors assessed the accuracy of their technique relative to target size/location, and respiration inconsistencies from the R-DTS to OB-DTS. RESULTS In both simulation and experimental studies, the respiration-phase-matched DTS technique is significantly more accurate in determining moving target positions. For 324 different scenarios simulated by XCAT, the respiration-phase-matched DTS technique localizes the 3D target position to errors of 1.07 ± 0.57 mm (mean ± S.D.), as compared to (a) 2.58 ± 1.37 and (b) 7.37 ± 4.18 mm, for 3D-DTS using 3D reference CT of (a) average intensity projection and (b) free-breathing CT. For 60 scenarios evaluated through experimental study, the uncertainties corresponding to those above are 1.24 ± 0.87, 2.42 ± 1.80, and 5.77 ± 6.45 mm, respectively. For a given scan angle, the accuracy of respiration-phase-matched DTS technique is less dependent on RC and the fraction of RC included in the scan. Increasing scan angle improves its accuracy. For different target locations, the targets near the chest wall or in the middle of lung provide higher registration accuracy compared to those near the mediastinum and diaphragm. Larger targets provide higher registration accuracy than small targets. Different respiratory cycle inconsistencies from R-DTS to OB-DTS minimally affect the registration accuracy. Increasing the respiratory amplitude inconsistencies will decrease the accuracy. CONCLUSIONS The respiration-phase-matched DTS is more accurate and robust in determining moving target positions than 3D-DTS. It has potential application in pretreatment setup, post-treatment analysis, and intrafractional target verification.
Unpredictable Work Timing in Retail Jobs

Unpredictability is a distinctive dimension of working time that has been examined primarily in the context of unplanned overtime and in male-dominated occupations. The authors assess the extent to which female employees in low-skilled retail jobs whose work schedules are unpredictable report greater work–life conflict than do their counterparts with more predictable work schedules and whether employee input into work schedules reduces work–life conflict. Data include measures from employee surveys and firm records for a sample of hourly female workers employed across 21 stores of a U.S. women’s apparel retailer. Results demonstrate that, independent of other dimensions of nonstandard work hours, unpredictability is positively associated with three outcomes: general work–life conflict, time-based conflict, and strain-based conflict as measured by perceived employee stress. Employee input into work schedules is negatively related to these outcomes. Little evidence was found that schedule input moderates the association between unpredictable working time and work–life conflict.
Macro Policy Responses to Price Shocks

IN RECENT YEARS the standard view of the inflation process has become complicated by the realization that inflationary bursts can emanate from supp'y as well as from demand disturbances. Supply-side disturbances, reflected mainly in rising food and oil prices, generated sharp increases in general price levels in most countries of the world during the 1973-75 period. The impact in the United States was magnified by wage-price catch-ups after the ending of controls, the productivity slowdown, the decline in the dollar, and a number of legislative measures resulting in higher costs and prices. More recently, the decline of oil production in Iran and rising farm prices are kindling fears of new supply-shock inflation. Price shocks from the supply side differ from traditional demand-pull disturbances because they can occur even at low levels of aggregate demand. Indeed, both theory and data suggest that supply shocks are more likely to be associated with recessions than with booms. Because this is so, standard remedies for dealing with supply-side inflation are not readily apparent. Most economists now more or less agree that aggregate demand policy should not permit unemployment o fall below its natural, or nonaccelerating-inflation, rate for any length of time. But whether unemployment should be allowed to rise above its natural rate in the presence of a
Performance Measures, Ranking and Parental Choice: An Analysis of the English School League Tables

ABSTRACT Parental choice among schools in England is informed by annually published school performance (league) tables. The 2006 league tables included a measure of contextual value added (CVA) for the first time. By explicitly accounting for the characteristics of a school's intake, the aim is that CVA should isolate the impact a school has on its pupils' progress and so provide a measure of school effectiveness. In this paper we use UK government administrative data to replicate CVA and other key performance measures in order to investigate the extent to which the current league tables provide the information necessary to support parental choice on the basis of school effectiveness. We find that school rankings based on CVA are largely uninformative for parents: almost half of English secondary schools are indistinguishable from the national average level of CVA.
Civic Culture and Democracy from Europe to America

In this study we explore the extent to which the civic cultures of European immigrants to the United States persist in their contemporary descendants. Analyses using data from the World Values Survey and the cumulative General Social Surveys indicate that the civic attitudes of contemporary Americans bear a strong resemblance to the civic attitudes of the contemporary citizens of the European nations with whom they share common ancestors. The Americans who descend from nations with highly civic populations tend to hold relatively civic attitudes, while those who descend from nations with less civic populations tend to hold relatively less civic attitudes. The significance of these findings for democracy is discussed.
Institutions in the Mexican coffee sector : changes and responses

Keywords: Cooperation, contract arrangements, traders´ performance, market uncertainty, diversification, coffee, Mexico. The main aim of this thesis is to investigate the institutional environment prevailing in the Mexican coffee sector and its effect on the producers, traders and households. Specific topics we examine are the contract arrangements and trade performance, the factors influencing the growers´ willingness to join a cooperative, the effects of cooperation on price variability, the influence of cooperation on the growers’ welfare, and coffee producers’ response to the falling coffee price through their engagement in diversification activities. To accomplish the main objectives we have used primary and secondary data. We applied ordinarily least squares, logistic, probit and multivariate probit regressions in the analysis. The main findings indicate that farmers were better off under the quota system than they are under the free market. Results also indicate that being a roaster and selling cherry coffee negatively affects traders’ use of contracts, whereas being vertically integrated has a positive effect on contracting. On the other hand, selling cherry coffee, participating in a competitive environment and having contracts positively influence intermediaries’ performance. Other results show that some individual, family and farm factors, as well as variability of the coffee price at the municipal level favour cooperative affiliation; whereas housing conditions, the proportion of farmers in the municipality and the level of producers selling to intermediaries at the municipal level negatively affect prospects for cooperative membership. We discovered overall positive effects of cooperative participation on household welfare through an increase in the price and total coffee income; results also indicate that households responded to the low coffee price periods with an increase in diversification.
Mechanisms of reducing postoperative pain, nausea and vomiting: a systematic review of current techniques

Background Multimodal recovery programmes decrease hospital stay. The objective of this systematic review was to assess how single-modality evidence-based care principles, regarding postoperative analgesia and postoperative nausea and vomiting (PONV) prophylaxis, combine to achieve this. Methods A systematic review of randomised controlled trials was performed. Relevant trials compared postoperative epidural analgesia/parenteral opioid analgesia/paracetamol/non-steroidal anti-inflammatory drugs (NSAIDs) and postoperative antiemetics. The effect on recovery was evaluated in terms of length of hospital stay, pain intensity, duration of gastrointestinal dysfunction and incidence of PONV. Results Twenty-three trials were included. Epidural anaesthesia failed to reduce length of stay or the incidence of PONV when compared to controls. Pain intensity and time to first bowel movement were reduced (p<0.05). Paracetamol did not reduce the incidence of PONV. NSAIDs reduced postoperative opioid consumption and the incidence of PONV (p<0.05). Dexamethasone and 5-HT3 antagonists reduced the incidence of PONV compared to controls. Conclusions Epidural anaesthesia appears to not reduce length of hospital stay or incidence of PONV despite reducing pain intensity and ileus. NSAIDs are more effective than paracetamol in reducing postoperative opioid consumption and PONV, while dexamethasone and 5-HT3 antagonists are both effective in reducing PONV.
Testing the Theoretical Proposition of Exchange Market Pressure: The Nigerian Experience

In this paper, monetary model of Exchange Market Pressure (EMP) is applied to Nigerian economy over the period 1970 to 2010. In support of the EMP propositions, dynamic ordinary least squares (DOLS) results reveal that domestic credit has stable significant negative relationship with exchange market pressure. The findings also provide evidence that Nigerian monetary authorities absorbed most of the exchange market pressure by adjusting the foreign reserves. The overall results indicate that the Nigeria’s experience provides another good example to test the theoretical propositions of the Girton-Roper monetary model of exchange market pressure. The Bretton Woods system known as the international monetary regime existed from the end of World War II until the early 1970s. Under the Bretton Woods system, all the member countries consented to tie their currency to US dollar and to peg their exchange rates. These countries also agreed to purchase and sell U.S. dollars in order to maintain their currencies within 1% of the fixed rate (Strange, 1976). In addition, these countries had right to alter their par value when necessary and in line with agreed procedures to correct basic external imbalances. The central banks of countries other than the United States did this by intervening in foreign exchange markets. If a country's currency was too high relative to the dollar, its central bank would sell its currency in exchange for dollars, driving down the value of its currency. Conversely, if the value of a country's money was too low, the country would buy its own currency, thereby driving up the price. The economic implication of maintaining currencies within 1% of fixed rate is to avoid excessive depreciation or appreciation against US dollar. Thus, countries with
How to Measure Analyst Forecast Effort

Abstract We introduce a new way to measure the forecast effort that analysts devote to their earnings forecasts by measuring the analyst's general effort for all covered firms. While the commonly applied effort measure is based on analyst behaviour for one firm, our measure considers analyst behaviour for all covered firms. Our general effort measure captures additional information about analyst effort and thus can identify accurate forecasts. We emphasise the importance of investigating analyst behaviour in a larger context and argue that analysts who generally devote substantial forecast effort are also likely to devote substantial effort to a specific firm, even if this effort might not be captured by a firm-specific measure. Empirical results reveal that analysts who devote higher general forecast effort issue more accurate forecasts. Additional investigations show that analysts' career prospects improve with higher general forecast effort. Our measure improves on existing methods as it has higher explanatory power regarding differences in forecast accuracy than the commonly applied effort measure. Additionally, it can address research questions that cannot be examined with a firm-specific measure. It provides a simple but comprehensive way to identify accurate analysts.
Differing effects of the cannabinoid agonist, CP 55,940, in an alcohol or Tween 80 solvent, on prepulse inhibition of the acoustic startle reflex in the rat

It has been suggested that cannabinoid agonists increase dopamine (DA) transmission in the mesolimbic dopamine system. However, evidence for such an effect is inconsistent. Prepulse inhibition (PPI) of the acoustic startle reflex is a behavioural paradigm that is modulated by an increase of mesolimbic dopamine. This study sought to ascertain whether or not a cannabinoid agonist, CP 55,940, mimicked the effects of amphetamine (a drug which increases dopamine release) on PPI. The first experiment measured the PPI of 16 male Wistar rats injected (i.p.) with different doses of CP 55,940 in a Latin-square design. A second experiment replicated the effects of the first experiment in a between-subjects design, and also examined the effects of using a 5% alcohol solution as a solvent for cannabinoid agonists, in comparison to the more inert detergent, Tween 80. In both experiments, CP 55,940 in Tween 80 significantly reduced basal activity, increased startle onset latencies and increased PPI, effects opposite to those of amphetamine. These results suggest that the net behavioural effects of cannabinoids are opposite to those of amphetamine. In addition, it was found that 1 ml/kg of a 5% alcohol solution has significant behavioural effects on its own, and reverses the effects of CP 55,940 on PPI.
The Internet and Civic Engagement

Civic involvement has long been dominated by those with high levels of income and education, leading some advocates to hope that online access might alter this pattern. But this report shows that the internet is not changing the socio-economic character of civic engagement in America. When it comes to online activities such as contributing money, contacting a government official or signing an online petition, the wealthy and well-educated continue to lead the way. Still, there are hints that the new forms of civic engagement anchored in blogs and social networking sites could alter long-standing patterns. Some 19% of internet users have posted material online about political or social issues or used a social networking site for some form of civic or political engagement. And this group of activists is disproportionately young.
Factors Associated with the Use of and Compliance with the IIA Standards: A Study of Anglo-Culture CAEs

Chief audit executives (CAEs) are required to use and comply with The International Standards for the Professional Practice of Internal Auditing (Standards). However, this study finds that 13.5 percent of CAEs in Anglo-culture countries do not use the Standards. Furthermore, of those who use the Standards a significant number fail to comply with specific standards. Multivariate tests of data from CAEs in this study show that ‘Length of IIA membership’ and ‘Internal auditing certification’ are positively associated with use. Other significant variables are ‘Superseded by local/government regulations or standards,’‘Not perceived as value added by management/board’ and ‘Compliance not expected in the country’ that are inversely related to use. The length of training is also positively associated with compliance, while other significant variables are internal audit certification, ‘Standards are too costly,’‘Not perceived as value added by management/board’ and ‘Inadequate internal audit staff’ that are negatively associated with compliance. The paper ends with a discussion of the implications of these results for practice and research.
Robust Portfolio Optimization with Multiple Experts

We consider mean-variance portfolio choice of a robust investor. The investor receives advice from J experts, each with a different prior for the distribution of returns. Confronted with these multiple priors the investor follows a min-max portfolio strategy. We study the structure of the robust mean-variance portfolio and empirically compare its performance with a variety of alternative portfolio strategies. The empirical tests are based on bootstrap simulations on the 25 Fama-French portfolios and on 81 European country and value portfolios. We find that the robust portfolio performs well in both settings. Robust portfolios do not exhibit the extreme weights typically observed in naive mean-variance portfolios. Robust portfolios are also better diversified than portfolios that impose short-sell constraints to suppress the symptoms of extreme weights.
Behavior of free testosterone in patients with prostate cancer on androgen deprivation therapy.

OBJECTIVES Determination of free testosterone (FT) serum level is an efficient method to evaluate bioavailable testosterone. We analyzed the behavior of serum FT in patients with prostate cancer receiving androgen deprivation therapy (ADT) and correlated FT with total testosterone (TT). We also analyzed the efficiency of both isoforms in the evaluation of the ADT. METHODS Serum levels of TT and FT were determined in 191 patients with prostate cancer in a cross-sectional study. A subset of 56 patients submitted only to radical prostatectomy served as control group. The remaining 135 patients with advanced prostate cancer on three-month LHRH agonist treatment comprised the study group. The median age of the population was 73 years (range, 53-86 years) and the median time on ADT was 42 months (6-198). RESULTS A significant correlation and linear regression between TT and FT was observed (r2 0.948). The efficiency of TT and FT to discriminate patients with and without ADT was similar (AUC: 0.993 and 0.995, respectively, p>0.05). A castration level of serum FT established at 1.7 pg/mL had a sensitivity of 85.9% and a specificity of 100%, which are similar to the sensitivity and specificity of 50 ng/dL of TT. All patients without ADT had levels of serum TT and FT above the castration level. In 19 of the 135 (14.1%) patients on ADT serum TT was above 50 ng/dL. In 12 of these 19 patients (63.2%) serum FT was below 1.7 pg/mL while in seven patients (5.2%) FT was also above the castration level. CONCLUSIONS The castration level of FT was established at 1.7 pg/mL. Serum TT and TF correlated very well; however, they seemed to provide complementary information in the evaluation of ADT efficiency. 14.1% of the patients on ADT failed to reach the castration level of serum TT; determination of serum FT in these patients would reduce this rate to 5.2%. (Int J Biol Markers 2005; 20: 119-22).