Miracle-dz/UniFAR-FTUs huggingface dataset:
Potential future methane emission hot spots in Greenland

Climate models have been making significant progress encompassing an increasing number of complex feedback mechanisms from natural ecosystems. Permafrost thaw and subsequent induced greenhouse gas emissions, however, remain a challenge for climate models at large. Deducing permafrost conditions and associated greenhouse gas emissions from parameters that are simulated in climate models would be a helpful step towards estimating emission budgets from permafrost regions. Here we use a regional climate model with a 5 km horizontal resolution to assess future potential methane (CH4) emissions over presently unglaciated areas in Greenland under an RCP8.5 scenario. A simple frost index is applied to estimate permafrost conditions from the model output. CH4 flux measurements from two stations in Greenland; Nuuk representing sub-Arctic and Zackenberg high-Arctic climate, are used to establish a relationship between emissions and near surface air temperature. Permafrost conditions in Greenland change drastically by the end of the 21st century in an RCP8.5 climate. Continuous permafrost remains stable only in North Greenland, the north-west coast, the northern tip of Disko Island, and Nuussuaq. Southern Greenland conditions only sustain sporadic permafrost conditions and largely at high elevations, whereas former permafrost in other regions thaws. The increasing thawed soil leads to increasing CH4 emissions. Especially the area surrounding Kangerlussuaq, Scoresby Land, and the southern coast of Greenland exhibit potentially high emissions during the longer growing season. The constructed maps and budgets combining modelled permafrost conditions with observed CH4 fluxes from CH4 promoting sites represent a useful tool to identify areas in need of additional monitoring as they highlight potential CH4 hot spots.
Response of Grazing Land Soil Health to Management Strategies: A Summary Review

Grazing land ecosystem services including food provision and climate regulation are greatly influenced by soil health. This paper provides a condensed review of studies on the response of three important soil properties related to soil health to grazing land management: water infiltration, carbon (C) sequestration, and nitrogen use efficiency (NUE). Impacts of management strategies that are often used in grazing lands are discussed in this review including vegetation composition, grazing methods, and other factors such as fertilizer use and climatic conditions. In general, proper grazing management such as continuous moderate grazing and rotational/deferred-rotational grazing with low or moderate stocking rates tends to benefit all three soil properties. Water infiltration can usually be increased with full vegetation cover, increased soil C, and aggregate stability, or be decreased with greater soil bulk density. Adoption of highly productive plant species with faster turnover rates can promote soil C sequestration by increasing C input. However, excessive C removal from ecosystems due to overgrazing or improper soil fertilization management results in higher C loss, which can have detrimental effects on soil C sequestration. Proper stocking rate and a balanced manure/fertilizer management was found to be critical for enhancing NUE. Grazing land management sometimes simultaneously influence the three soil properties. Techniques that can increase soil C such as introduction of high productive plant species can often promote water infiltration and soil nitrogen (N). Some other practices such as adoption of N fertilizer may enhance C sequestration while being detrimental to NUE. An integrated management plan for a specific location or farm should be considered carefully to improve soil health as well as ecosystem production. This review provides farmers and policy makers the current state of general knowledge on how health-related soil processes are affected by grazing land management.
De facto regulatory decision-making processes in telecommunications regulation: explaining influence relationships with exponential random graph models

Abstract Research on regulation has focussed on explaining the independence of sector regulators and assessing the effects of regulations on markets. This article broadens the scope of such research by studying and explaining how regulatory actors interact at the de facto level in a multi-actor regulatory arrangement when making regulatory decisions in the telecommunications sector of Colombia. We propose that regulatory decisions depend on the manner in which actors influence each other. In this article, we are not only focussing on the policy outcome itself but also on the regulatory decision-making process. We performed a social network analysis and used an exponential random graph model to analyse the data. Our findings suggest that actors’ level of influence is affected by the access they have to other organisations, the divergence of positions they have with these other organisations and the power resources of an organisation. In addition, there are structural network characteristics that affect regulatory decisionmaking.
Polymerase chain reaction for microsporidian DNA in gastrointestinal biopsy specimens of HIV-infected patients.

OBJECTIVE To study the accuracy of polymerase chain reaction (PCR) for microsporidian DNA in gastrointestinal biopsy specimens of HIV-infected patients for the diagnosis of intestinal microsporidiosis. SETTING Infectious disease in- and outpatient clinic of a university hospital in Cologne, Germany. PATIENTS Forty-six HIV-infected patients with diarrhoea. METHODS PCR and Southern blot hybridization were performed using DNA extracted from intestinal biopsy specimens with primers and probes from the small subunit rRNA gene of Enterocytozoon bieneusi and Septata intestinalis. Histological examination of intestinal biopsy specimens was performed using a fluorescence technique. Transmission electron microscopy of intestinal biopsy specimens was performed in 13 patients. RESULTS Amplification and Southern blot hybridization with species-specific primers and probes gave positive results in 10 patients for E. bieneusi, and in 10 patients for S. intestinalis. Overall, five cases of double infection with E. bieneusi and S. intestinalis were seen when both primer pairs and probes were used. Histological examination showed microsporidian spores in all 15 cases, but light microscopy was unable to distinguish between species in almost all cases. CONCLUSIONS PCR detection of microsporidian DNA in intestinal biopsy specimens can be used reliably for the diagnosis of intestinal microsporidiosis in HIV-infected patients and is also useful for species differentiation between microsporidia. Infections with S. intestinalis and double infections with two types of microsporidia appear to be more common than previously described.
Women's Career in the U. S. Federal Government: Wage, Promotion, Leave and Fertility

This dissertation investigates female career progress in the U. S. federal government in aspects of wage, promotion, leave, and fertility. It sheds lights on how women face trade-offs between career and fertility and how the gender decomposition of supervisors affects gender wage and promotion gaps. The first chapter examines how female leadership affects the gender wage gap in the U. S. federal government. Using a unique dataset from the Office of Personnel Management, I track careers of civilian employees from 1988 to 2011. I find that in offices where all supervisors are men, male wages are on average 10.6% higher than female wages. In contrast, in offices where all supervisors are women, the wage gap in favor of men disappears and becomes 3.2% in favor of women due to a 7.1% increase in female wages and a 6.7% decline in male wages. Also, the gender of an executive (a higher level supervisor) has a lesser impact on wages than the gender of regular supervisors. However, the gender of an executive has a greater impact on wages of supervisors than on wages of non-supervisors, which is consistent with the theory of mentorship. I account for potential endogeneity caused by a non-random assignment of supervisors by using office fixed effects and an instrumental variable based on retirement. Finally, I investigate potential mechanisms by examining promotions, exits, starting, and exiting positions. The second chapter examines the effects of the Family Medical Leave Act (FMLA) on the promotion of women into managerial positions using the Office of Personnel Management (OPM) data and imputed fertility rates from Centers for Disease Control and Prevention (CDC) data. I find that after the FMLA was passed in 1993, there was a significant change in the relationship between fertility and promotion, with fertility becoming more negatively associated with promotion. Compared to the relationship prior to 1993, a 10% increase in fertility is associated with an additional 1.3% decline in the probability of being promoted. This suggests that the FMLA may have inhibited
Single-Level Instrumented Posterolateral Fusion of Lumbar Spine With &bgr;-Tricalcium Phosphate Versus Autograft: A Prospective, Randomized Study With 3-Year Follow-up

Study Design. A prospective, randomized clinical study comparing &bgr;-tricalcium phosphate (&bgr;-TCP) with autograft bone graft with follow-up of 3 years. Objective. To determine the efficacy of &bgr;-TCP as a bone graft substitute combined with local autograft obtained from decompression compared with the use of autologous iliac crest bone graft in single-level instrumented posterolateral lumbar fusion. Summary of Background Data. A variety of bone graft substitutes have been used in posterolateral lumbar fusion with different efficacy reported, but no controlled study was conducted on the clinical performance of &bgr;-TCP in instrumented posterolateral lumbar fusion. Methods. Sixty-two patients with symptomatic degenerative lumbar spinal stenosis were treated with single-level instrumented posterolateral lumbar fusion. They were randomly assigned to fusion with &bgr;-TCP combined with local bone obtained from the decompression (group A, n = 32) or autogenous iliac crest bone graft plus decompression bone (group B, n = 30). The patients were observed up for 3 years after surgery. The results were assessed clinically and radiographically. Results. There were no significant differences in recovery rate of Japanese Orthopedic Association score and SF-36 score at all time intervals. Successful radiographic fusion was documented in all patients in both treatment groups. All patients in group B, however, complained bone graft donor site pain although significant improvement of pain was observed during the follow-up. Conclusion. Instrumented posterolateral fusion with &bgr;-TCP combined with local autograft results in the same radiographic fusion rates and similar improvement of clinical outcomes and life quality compared with autograft alone. The authors therefore recommend the use of &bgr;-TCP as bone graft substitute for instrumented posterolateral fusion of lumbar spine to eliminate the need of bone grafting harvesting from the ilium.
Homocysteine plasma levels in patients treated with antiepileptic drugs depend on folate and vitamin B12 serum levels, but not on genetic variants of homocysteine metabolism

Abstract Background: Antiepileptic drugs (AEDs) are commonly used in the treatment of epilepsy, psychiatric diseases and pain disorders. Several of these drugs influence blood levels of folate and vitamin B12 and, consequently, homocysteine. This may be relevant for AED effects and side effects. However, not only folate and vitamin B12, but also genetic variants modify homocysteine metabolism. Here, we aimed to determine whether there is a pharmacogenetic interaction between folate, vitamin B12 and genetic variants and homocysteine plasma level in AED-treated patients. Methods: In this mono-center study, we measured homocysteine, folate and vitamin B12 plasma levels in a population of 498 AED-treated adult patients with epilepsy. In addition, we analyzed the genotypes of seven common genetic variants of homocysteine metabolism: methylenetetrahydrofolate reductase (MTHFR) c.677C>T and c.1298A>C, methionine synthase (MTR) c.2756A>G, dihydrofolate reductase (DHFR) c.594+59del19bp, cystathionine β-synthase (CBS) c. 844_855ins68, transcobalamin 2 (TC2) c.776C>G and methionine synthase reductase (MTRR) c.66G>A. Results: On multivariate logistic regression, folate and vitamin B12 levels, but none of the genetic variants, were predictive for homocysteine levels. Conclusions: These data suggest that, in AED-treated patients, folate and vitamin B12 play important roles in the development of hyperhomocysteinemia, whereas genetic variants of homocysteine metabolism do not and thus do not contribute to the risk of developing hyperhomocysteinemia during AED treatment.
Effects of Postnatal Age and Aminophylline on the Maturation of Amplitude-Integrated Electroencephalography Activity in Preterm Infants

Background: The use of amplitude-integrated electroencephalography (aEEG) is increasing during the neonatal intensive care of preterm infants. Objective: This prospective study was designed to assess factors that affect the maturation of aEEG activity in preterm infants with a gestational age (GA) of <32 weeks. Methods: aEEGs with cerebral function monitoring were performed weekly in preterm infants, and the recordings were evaluated and scored to assess the degree of continuity, the degree of sleep-wake cycling, and the amplitude of the lower border. Subjects with any of the following conditions were excluded: intraventricular hemorrhage or periventricular leukomalacia on cranial ultrasonography, sedation, hypotension, or respiratory instability (FiO2 >50%). Results: The authors analyzed 207 recordings in 35 infants (GA 24–31 weeks, birth weight 440–1,980 g, postmenstrual age 25–38 weeks). At postmenstrual age 34–36 weeks, the aEEG total score was higher in preterm infants with a GA from 24 to 28 weeks than in less premature infants with a GA from 29 to 31 weeks (aEEG total score 12 vs. 10, p < 0.05). Logistic regression analysis revealed that the sleep-wake cycling was more prominent in infants with higher postnatal age (OR 3.32, 95% CI 2.40–4.59) or those receiving aminophylline (OR 3.28, 95% CI 1.06–10.08). Conclusions: The maturation of aEEG activity was found to be significantly correlated with postnatal age and with aminophylline use in clinically stable preterm infants. Most notably, aminophylline was found to be significantly associated with the degree of sleep-wake cycling as indicated by aEEG activity.
Are Founder-Led Firms Less Susceptible to Managerial Myopia?

Considerable evidence suggests that CEOs often behave myopically. It is open to debate, however, whether managerial myopia is equally prevalent among founder-led firms. Drawing on agency theory and stewardship theory, we analyze whether founder-led firms are less likely than nonfounder-led firms to cut R&D expenditures in order to meet the short-term earnings goals suggested by these firms’ past performance histories. Our analysis of Standard & Poor’s 1,500 companies from 1992 to 2013 indicates that myopia is an enduring phenomenon and prevalent among very large companies. However, founder-led firms are less likely than nonfounder-led firms to exhibit myopic behavior.
Polyherbal preparation for anti-diabetic activity: a screening study.

OBJECTIVE To screen the Polyherbal preparation for anti-diabetic activity in rats. MATERIALS AND METHODS The blood glucose lowering activity of the Polyherbal preparation-I (1:1:1 of Wheat germ oil, Coriandrum sativum and Aloe vera) was studied in normal rats after oral administration at doses of 1.0 and 2.0 ml/kg and Polyherbal preparation-I, II (Wheat germ oil, fresh juice of C. sativum and Aloe vera in the ratio of 2:2:1), and III (Wheat germ oil, fresh juice of C. sativum and Aloe vera in the ratio of 1:2:2) on alloxan-induced diabetic rats, after oral administration at doses of 1.0 and 2.0 ml/kg. Blood samples were collected from the tail vein method at 0, 0.5, 1, 2, 4, 8, 12, and 24 h in normal rats and in diabetic rats at 0, 1, 3, 7, 15, and 30 days. Blood plasma glucose was estimated by the GOD/POD (glucose oxidase and peroxidase) method. The data was compared statistically using the one-way ANOVA method followed by the Dunnett multiple component test. Statistical significance was set at P<0.05. RESULTS The Polyherbal preparation-I produced significant (P<0.05) reduction in the blood glucose level of normal rats and Polyherbal preparation-I, II, and III produced significant (P<0.01) reduction in the blood glucose level of diabetic rats during 30 days study and compared with that of control and Glibenclamide. CONCLUSION The Polyherbal preparation-I showed a significant glucose lowering effect in normal rats and Polyherbal preparation-I, II, and III in diabetic rats. This preparation is going to be promising anti-diabetic preparation for masses; however, it requires further extensive studies in human beings.
Different proteasome subtypes in a single tissue exhibit different enzymatic properties.

It is concluded from many experiments that mammalian tissues and cells must contain a heterogeneous population of 20 S proteasome complexes. We describe the purification and separation by chromatographic procedures of constitutive 20 S proteasomes, 20 S immuno-proteasomes and intermediate-type 20 S proteasomes from a given tissue. Our data demonstrate that each of these three groups comprises more than one subtype and that the relative ratios of the subtypes differ between different rat tissues. Thus, six subtypes could be identified in rat muscle tissue. Subtypes I and II are constitutive proteasomes, while subtypes V and VI comprise immuno-proteasomes. Subtypes III and IV belong to a group of intermediate-type proteasomes. The subtypes differ with regard to their enzymatic characteristics. Subtypes I-III exhibit high chymotrypsin-like activity and high peptidylglutamylpeptide hydrolysing activity, while these activities are depressed in subtypes IV-VI. In contrast, trypsin-like activity of subtypes IV-VI is enhanced in comparison to subtypes I-III. Importantly, the subtypes also differ in their preferential cleavage site usage when tested by digestion of a synthetic 25mer polypeptide substrate. Therefore, the characteristics of proteasomes purified from tissues or cells represent the average of the different subtype activities which in turn may have different functions in vivo.
Association of Body Shape Index (ABSI) with cardio-metabolic risk factors: A cross-sectional study of 6081 Caucasian adults

A Body Shape Index (ABSI) was specifically developed as a transformation of waist circumference (WC), statistically independent of BMI to better evaluate the relative contribution of WC to central obesity and clinical outcomes. Previous studies have found ABSI is associated with total mortality and cardiovascular events. However, no study has specifically evaluated the joint contribution of ABSI and BMI to cardio-metabolic outcomes (high triglycerides, low HDL, high fasting glucose and high blood pressure). With this aim, we performed a retrospective study on 6081 Caucasian adults. Subjects underwent a medical interview, anthropometric measurements, blood sampling, measurement of blood pressure, and measurement of visceral abdominal fat thickness (VAT) by ultrasound. Generalized linear models (GLM) were used to evaluate the sex and age adjusted association of ABSI with binary and continuous cardio-metabolic risk factors. Four pre-specified GLM were evaluated for each outcome: M1 = ABSI, BMI and ABSI*BMI interaction, M2 = ABSI and BMI, M3 = ABSI alone and M4 = BMI alone. Bayesian Information Criterion (BIC) was calculated and used to identify the best predictive model. ABSI and BMI contributed independently to all outcomes. Compared to BMI alone, the joint use of BMI and ABSI yielded significantly improved associations for having high triglycerides (BIC = 5261 vs. 5286), low HDL (BIC = 5371 vs. 5381), high fasting glucose (BIC = 6328 vs. 6337) but not high blood pressure (BIC = 6580 vs. 6580). The joint use of BMI and ABSI was also more strongly associated with VAT than BMI alone (BIC = 22930 vs. 23479). In conclusion, ABSI is a useful index for evaluating the independent contribution of WC, in addition to that of BMI, as a surrogate for central obesity on cardio-metabolic risk.
Trade Size Preference of Informed Traders in Indian Equity Markets

ABSTRACT This study utilized high frequency transactions data to analyze the trade size preference of informed traders in Indian equity markets. It is observed that informed traders at an aggregate level adopt stealth trading strategy, wherein they prefer medium sized trades over large sized trades in order to camouflage their private information. However, the stealth trading behavior varies across stocks, wherein informed traders prefer more large sized trades on firms that are part of an index compared to non-index firms. Trading behavior also varies across other market conditions. It has been noted that informed traders prefer large sized trades during periods of high market thickness, negative returns, and low volatility. This study also provides a rationale for such varied behavior of informed traders.
Oral liquid levothyroxine solves the problem of tablet levothyroxine malabsorption due to concomitant intake of multiple drugs

ABSTRACT Background: Unlike the tablet (TAB) formulation, liquid L-T4 (LIQ) is directly absorbed in the intestine. The aim of this study was to assess whether LIQ was superior to TAB, such that it would overcome the interference induced by co-ingestion of multiple interfering drugs (ID). Methods: In this prospective cohort study, we recruited 11 patients with apparent reduced TAB absorption due to ≥ 2 ID, and switched them to LIQ while maintaining the daily dose and the co-ingestion of the ID. Serum TSH was assayed at least twice every eight weeks. Results: Serum TSH was significantly lower on LIQ compared with TAB (P < 0.0001), in patients who took L-T4 for either replacement (P = 0.002) or TSH-suppression (P < 0.0001). This difference was evident already at the first measurement post-switch (P = 0.008 or P = 0.03). Regardless of the purpose of L-T4 therapy, patients who took two ID had lower serum TSH on LIQ compared with patients who took three ID (P = 0.0006). Interestingly, 2/3 patients who failed to reach target TSH levels while on LIQ took three ID. Conclusions: LIQ overcomes the concurrent interference exerted by the ingestion of multiple ID. In such cases, switching from TAB to LIQ permits patients to reach target TSH within 8 weeks.