Miracle-dz/UniFAR-FTUs huggingface dataset:
Treatment of depressed mothers of depressed children: Pilot study of feasibility

Numerous studies have shown that depression is highly familial and impairing and that a history of depression in a parent is the strongest risk factor for depression in a child. Many of the parents in these studies have never received sustained treatment despite histories of recurrent depression. None of the studies have examined the effects of maternal symptom remission on offspring symptom or functioning. We sought to determine the feasibility of treating depressed mothers who brought an offspring for the treatment of depression and to examine the relationship between improved maternal depression and symptomatic improvement and social functioning in their offspring. Nine mothers bringing their offspring for treatment of depression, and who were evaluated and found to be currently depressed, completed a 12‐week open trial of interpersonal psychotherapy. Mothers and their depressed offspring were assessed by independent evaluators at weeks 0, 6, and 12 for depressive symptomatology and social functioning. Although the rates of depression were high among the mothers, few eligible mothers agreed to participate. Of the 12 who entered treatment, 9 (75%) completed it. Mothers and offspring improved with regard to depressive symptomatology and global functioning over the course of the trial. Improvement in maternal depression was significantly associated with improvement in offspring functioning but not symptom reduction. Improvement of maternal depression may be associated with improved outcomes in depressed offspring. However, it is difficult to engage depressed mothers in treatment for themselves if they come to the clinic to bring their child for treatment of depression. It may be more feasible to study the effect of improved maternal depression on offspring by sampling depressed mothers coming for their own treatment and then assessing their children over the course of maternal treatment. Depression and Anxiety 19:51–58, 2004. © 2004 Wiley‐Liss, Inc.
Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics

The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of methylisothiazolinone (MI), which functions as a preservative. The Panel reviewed relevant animal and human data provided in this safety assessment and in a previously published safety assessment of MI and concluded that MI is safe for use in rinse-off cosmetic products at concentrations up to 100 ppm and safe in leave-on cosmetic products when they are formulated to be nonsensitizing, which may be determined based on a quantitative risk assessment.
Numerical response of a mammalian specialist predator to multiple prey dynamics in Mediterranean farmlands.

The study of rodent population cycles has greatly contributed, both theoretically and empirically, to our understanding of the circumstances under which predator-prey interactions destabilize populations. According to the specialist predator hypothesis, reciprocal interactions between voles and small predators that specialize on voles, such as weasels, can cause multi-annual cycles. A fundamental feature of classical weasel-vole models is a long time-lag in the numerical response of the predator to variations in prey abundance: weasel abundance increases with that of voles and peaks approximately one year later. We investigated the numerical response of the common weasel (Mustela nivalis) to fluctuating abundances of common voles (Microtus arvalis) in recently colonized agro-steppes of Castilla-y-Léon, north-western Spain, at the southern limit of the species' range. Populations of both weasels and voles exhibited multi-annual cycles with a 3 year-period. Weasels responded quickly and numerically to changes in common vole abundance, with a time-lag between prey and weasel abundance that did not exceed 4 months and occured during the breeding season, reflecting the quick conversion of prey into predator offspring and/or immigration to sites with high vole populations. We found no evidence of a sustained, high weasel abundance following vole abundance peaks. Weasel population growth rates showed spatial synchrony across study sites c.60 km apart. Weasel dynamics were more synchronized with that of common voles than with other prey species (mice or shrews). However, asynchrony within, as well as among sites, in the abundance of voles and alternative prey suggests that weasel mobility could allow them to avoid starvation during low vole phases, precluding the emergence of prolonged time-lag in the numerical response to voles. Our observations are inconsistent with the specialist predator hypothesis as currently formulated and suggest that weasels might follow rather than cause the vole cycles in north-western Spain. The reliance of a specialized predator on a functional group of prey such as small rodents does not necessarily lead to a long delay in the numerical response by the predator, depending on the spatial and inter-specific synchrony in prey dynamics. This article is protected by copyright. All rights reserved.
The Impact of Business Size and Business Type on Small Business Investment in Electronic Commerce: a study of Swedish small businesses

In the past, organisations relied on traditional quantitative metrics, such as Return on Investment (ROI) to make decisions when investing in technology. With the advent of electronic commerce (EC), organisations have had to rethink their investment and acquisition decisions due to the strategic nature of electronic commerce. Where ROI measures have failed, they have been replaced with a plethora of organisational driving forces. This paper focuses on the driving forces behind EC adoption by small and medium enterprises (SME's) and aims to determine the impact of organisational factors such as size and type of business on EC acquisition criteria. The results of a research study carried out in Sweden are presented and suggest that there exist high levels of significance between the size of the business and customer demand, reduced costs, developing new markets and improvement to marketing as driving forces, and the type of business and customer demand, pressure from competition, increased sales and improvement of relationship with business partners as driving forces for EC adoption.
Inhibition of the NKp44-PCNA Immune Checkpoint Using a mAb to PCNA

An immune checkpoint blocking antibody was developed against cancer cell surface PCNA, a ligand for NK-cell protein NKp44. Tests of the antibody in mice bearing patient-derived xenografts showed promise for overcoming tumor resistance to immunotherapy. mAb-based blocking of the immune checkpoints involving the CTLA4-B7 and PD1-PDL1 inhibitory axes enhance T-cell–based adaptive immune responses in patients with cancer. We show here that antitumor responses by natural killer (NK) cells can be enhanced by a checkpoint-blocking mAb, 14-25-9, which we developed against proliferating cell nuclear antigen (PCNA). PCNA is expressed on the surface of cancer cells and acts as an inhibitory ligand for the NK-cell receptor, NKp44-isoform1. We tested for cytoplasmic- and membrane-associated PCNA by FACS- and ImageStream-based staining of cell lines and IHC of human cancer formalin fixed, paraffin embedded tissues. The mAb, 14-25-9, inhibited binding of chimeric NKp44 receptor to PCNA and mostly stained the cytoplasm and membrane of tumor cells, whereas commercial antibody (clone PC10) stained nuclear PCNA. NK functions were measured using ELISA-based IFNγ secretion assays and FACS-based killing assays. The NK92-NKp44-1 cell line and primary human NK cells showed increased IFNγ release upon coincubation with mAb 14-25-9 and various solid tumor cell lines and leukemias. Treatment with 14-25-9 also increased NK cytotoxic activity. In vivo efficacy was evaluated on patient-derived xenografts (PDX)-bearing NSG mice. In PDX-bearing mice, intravenous administration of mAb 14-25-9 increased degranulation (CD107a expression) of intratumorally injected patient autologous or allogeneic NK cells, as well as inhibited tumor growth when treated long term. Our study describes a mAb against the NKp44-PCNA innate immune checkpoint that can enhance NK-cell antitumor activity both in vitro and in vivo.
Opposite Effects of SiO2 Nanoparticles on the Local α and Larger-Scale α’ Segmental Relaxation Dynamics of PMMA Nanocomposites

The segmental relaxation dynamics of poly(methyl methacrylate)/silica (PMMA/SiO2) nanocomposites with different compositions (ϕSiO2) near and above the glass transition temperature were investigated by mechanical spectroscopy. At ϕSiO2 ≤ 0.5%, the α peak temperature hardly changes with ϕSiO2, but that of α’ relaxation composed of Rouse and sub-Rouse modes decreases by 15 °C due to the increase of free volume. At ϕSiO2 ≥ 0.7%, both α and α’ relaxations shift to high temperatures because of the steric hindrance introduced by nanoparticle agglomeration. On the other hand, with increasing ϕSiO2, the peak height for α relaxation increases at ϕSiO2 ≤ 0.5% and then decreases at ϕSiO2 ≥ 0.7%, but that for α’ relaxation shows an opposite behavior. This is because at low ϕSiO2, the short-chain segments related to α relaxation can easily bypass the particles, but the longer-chain segments related to α’ relaxation cannot. At high ϕSiO2, the polymer chains were bound to the nanoparticles due to the physical adsorption effect, leading to the decrease of relaxation unit concentration involved in α relaxation. However, the dissociation of those bonds with heating and the concentration heterogeneity of polymer chains result in the increase of peak height for α’ relaxation.
InnovatIons In DetectIng anD treatIng Deep venous thrombosIs anD pulmonary embolIsm : optImal care for a potentIally lethal DIsease

Venous thromboembolism (VTE) is a clinical entity which includes deep vein thrombosis (DVT) and pulmonary embolism (PE). VTE is a common medical condition affecting up to 117 patients per 100,000 populations annually. The diagnosis of VTE is often difficult and is frequently missed. Mortality in untreated PE is approximately 30%, but with adequate anticoagulant treatment, this can be reduced to 2–8%. The purpose of this monograph is to focus on the diagnosis and treatment of VTE, including PE and DVT in the emergency department (ED).
How Well Represented Are Women Orthopaedic Surgeons and Residents on Major Orthopaedic Editorial Boards and Publications?

BACKGROUND Recent studies indicate that women are substantially underrepresented as orthopaedic surgeons and residents compared with other specialties in medicine and medical school. The reasons for this are multifactorial and not completely understood, but previous studies suggest that women may be attracted to fields in which they have female role models. Given that women interested in academia and research may use female editorship and authorship as a proxy for female representation in orthopaedic surgery, we wanted to examine the proportion of women represented in orthopaedic journals and determine if it reflects the distribution of women in orthopaedic surgery as a field. We further wanted to understand if this representation has changed over time in the setting of a slowly shifting gender landscape within orthopaedic surgery. QUESTIONS/PURPOSES (1) How are women orthopaedic surgeons and residents represented in orthopaedic journals compared with men? (2) Have these proportions changed in the past two decades in light of relatively new efforts to recruit women to the field of orthopaedic surgery? METHODS The gender composition of editorial boards and first and last authors were obtained from the 1997, 2007, and 2017 volumes of the following journals: The Journal of Bone & Joint Surgery (JBJS), the Journal of the American Academy of Orthopaedic Surgeons (JAAOS), and Clinical Orthopaedics and Related Research® (CORR®). Gender neutral names were searched to obtain a picture to ensure proper tallies. RESULTS The total combined amount of women first and last authors increased from 88 of 1450 (6%) in 1997 to 152 of 1912 (8%) in 2007 to 723 of 5391 (13%) in 2017. Similarly, three of 113 (3%) editorial board members were women in 1997, three of 105 (3%) were women in 2007 and 10 of 107 (9%) editors were women in 2017. Of note, 0 out of 9 editors-in-chief were women. CONCLUSIONS Based on the current percentage of women orthopaedic surgeons and residents, women are represented equally or in greater numbers as editors and authors in JAAOS, JBJS, and CORR. This may be in part due to women orthopaedic surgeons entering academic medicine at a greater rate than males. CLINICAL RELEVANCE Orthopaedic surgeons serving as mentors to prospective female applicants can cite female representation on editorial boards and as authors as an example of gender parity in the field. Additionally, active orthopaedic surgeons who are women interested in these leadership positions should be encouraged that these opportunities exist, regardless of gender.
Men’s Bodily Attractiveness: Muscles as Fitness Indicators

Bodily attractiveness is an important component of mate value. Musculature—a crucial component of men’s bodily attractiveness—provides women with probabilistic information regarding a potential mate’s quality. Overall musculature is comprised of several muscle groups, each of which varies in information value; different muscles should be weighted differently by attractiveness-assessment adaptations as a result. In the current study, women and men (N = 1,742) reported size preferences for 14 major muscle groups. Women’s reported preferences provided only partial support for our hypotheses that women will prefer muscles that most reliably differentiate between potential mates to be larger; men tended to prefer larger upper-body muscles. We discuss possible interpretations of these mixed findings. Ultimately, our findings suggest that attractiveness-assessment adaptations are sensitive to the information contained within specific muscle groups and they highlight the potential for additional research on the nuances of bodily attractiveness assessment.
Can goal-setting for patients with multimorbidity improve outcomes in primary care? Cluster randomised feasibility trial

Introduction Goal-setting is recommended for patients with multimorbidity, but there is little evidence to support its use in general practice. Objective To assess the feasibility of goal-setting for patients with multimorbidity, before undertaking a definitive trial. Design and setting Cluster-randomised controlled feasibility trial of goal-setting compared with control in six general practices. Participants Adults with two or more long term health conditions and at risk of unplanned hospital admission. Interventions General practitioners (GPs) underwent training and patients were asked to consider goals before an initial goal-setting consultation and a follow-up consultation 6 months later. The control group received usual care planning. Outcome measures Health-related quality of life (EQ-5D-5L), capability (ICEpop CAPability measure for Older people), Patient Assessment of Chronic Illness Care and healthcare use. All consultations were video-recorded or audio-recorded, and focus groups were held with participating GPs and patients. Results Fifty-two participants were recruited with a response rate of 12%. Full follow-up data were available for 41. In the goal-setting group, mean age was 80.4 years, 54% were female and the median number of prescribed medications was 13, compared with 77.2 years, 39% female and 11.5 medications in the control group. The mean initial consultation time was 23.0 min in the goal-setting group and 19.2 in the control group. Overall 28% of patient participants had no cognitive impairment. Participants set between one and three goals on a wide range of subjects, such as chronic disease management, walking, maintaining social and leisure interests, and weight management. Patient participants found goal-setting acceptable and would have liked more frequent follow-up. GPs unanimously liked goal-setting and felt it delivered more patient-centred care, and they highlighted the importance of training. Conclusions This goal-setting intervention was feasible to deliver in general practice. A larger, definitive study is needed to test its effectiveness. Trial registration number ISRCTN13248305; Post-results.
Body mass index, weight-adjusted immunosuppression and the risk of acute rejection and infection after kidney transplantation: a cohort study.

BACKGROUND Body mass index (BMI) is associated with patient outcomes after kidney transplantation. We hypothesized that immunosuppression (IS) dosing is a contributing factor. METHODS Using Australia and New Zealand Dialysis and Transplant registry data, we included all adult kidney-only transplant recipients over 2000-14 treated with prednisolone, mycophenolate and tacrolimus/cyclosporin (n = 7919). The exposure was BMI and the outcomes were time to: (i) acute rejection, (ii) fatal infection, (iii) cancer and (iv) graft; and (v) patient survival. We modelled BMI and IS dosing (in quartiles) as time-varying covariates in extended Cox models. RESULTS Compared with a BMI of 25 kg/m2, a BMI of 35 was associated with acute rejection after adjusting for demographics and comorbidities [adjusted hazard ratio (aHR) = 1.29, 95% confidence interval (CI) 1.12-1.49]. This association virtually disappeared after correcting for IS (aHR = 1.09, 95% CI 0.93-1.29). A BMI of 35 was non-significantly associated with fewer fatal infections (aHR = 0.91, 95% CI 0.66-1.25), but this reversed after adjusting for IS (aHR = 1.54, 95% CI 1.03-2.28). Results for cancer were not significantly altered after adjusting for IS. Results for lower BMI were similarly not significantly altered though generally associated with worse outcomes. CONCLUSIONS Our findings show that the associations between high BMI, acute rejection and fatal infection after kidney transplantation were significantly altered after correcting for IS suggesting that relative under-dosing of obese patients may partially explain these associations.
The evolution of femoral cross‐sectional properties in sciuromorph rodents: Influence of body mass and locomotor ecology

In several groups of mammals, adaptation to differing functional demands is reflected in long bone cross‐sectional properties (CSP), which relate to the resistance to compression and to bending loads in the craniocaudal and mediolateral directions. Members of the Sciuromorpha (“squirrel‐like” rodents) display a diversity of locomotor ecologies and span three orders of magnitude in terms of body size. The availability of robust phylogenies is rendering them a suitable group to further substantiate the relationship of long bone CSP with locomotor ecology and body mass while taking the phylogenetic non‐independence among species into account. Here, we studied 69 species of Sciuromorpha belonging to three lifestyle categories, “arboreal,” “fossorial,” and “aerial” (i.e., gliding). We hypothesized locomotor category specific loading regimes that act on femora during predominant or, in terms of gliding, critical locomotor behaviors of each category. High resolution computed tomography scans of the specimens' femora were obtained and cross‐sections in 5% increments were analyzed. Cross‐sectional area, the craniocaudal second moment of area (SMAcc), and the mediolateral second moment of area were quantified. Further, a scaling analysis was conducted for each bone cross‐section to examine how the CSP scale with body mass. Body mass accounted for variances in CSP with mainly positive allometry. The aerial sciuromorphs showed lower values of CSP compared to the arboreal and fossorial species in the distal epiphysis for all quantified parameters and along the bone for SMAcc. In contrast to previous studies on other mammalian lineages, no differences in CSP were found between the fossorial and the arboreal lifestyles.
Prevalence of and Characteristics Associated With Self-reported Good Hearing in a Population With Elevated Audiometric Thresholds.

Importance Audiometric evidence of hearing loss does not always relate to self-reported hearing loss. Objective To determine the prevalence of self-reported good hearing in a population with audiometrically defined hearing loss and identify associated factors. Design, Setting, and Participants We analyzed audiometric data from adults aged 20 to 69 years from the 1999 to 2002 cycles of the US National Health and Nutrition Examination Survey, a cross-sectional, nationally representative interview and examination survey of the civilian, noninstitutionalized population. Logistic regression was used to examine unadjusted and multivariable-adjusted relationships between demographic, hearing health, and general health factors related to self-perceived hearing status. Analysis was conducted between September 4, 2018, and November 30, 2018. Interventions Audiometry and questionnaires. Main Outcomes and Measure The prevalence of persons reporting good hearing among those with audiometrically defined hearing loss and the variables associated with this population. Results The mean (SD) age was 47.0 (0.4) years for hearing loss defined by any frequency >25 dB HL and 52.5 (1.1) years for hearing loss defined by PTA >25 dB HL. For the sample with hearing loss defined by any frequency >25 dB HL, 744 (56.1%) were men and 629 (43.9%) were women. For the sample with hearing loss defined by PTA >25 dB HL 251 (68.5%) were men and 114 (31.5%) were women. Of the 1373 participants who were found to have hearing loss (at least 1 individual frequency >25 dB HL in either ear) 993 (68.5%) reported good hearing. Younger age, nonwhite race, and women were all more likely to report good hearing. When the definition of hearing loss was made more stringent (pure-tone average >25 dB HL), 365 participants had audiometric hearing loss, but 174 (43%) continued to report good hearing. We observed that better self-perceived general health status (OR, 1.90; 95% CI, 1.25-2.90) and higher dietary quality (OR, 1.01; 95% CI, 1.00-1.02) were significantly associated with increased self-report of good hearing, whereas tinnitus (OR, 0.25; 95% CI, 0.14-0.44), noise exposure (OR, 0.39; 95% CI, 0.26-0.58), and several comorbid conditions were associated with decreased self-report of good hearing. Conclusions and Relevance A significant proportion of the study population reported good hearing despite having audiometric evidence of hearing loss; the prevalence was related to how hearing loss was defined. The report of good hearing was significantly associated with demographics and general health status. The high prevalence of mild hearing loss and self-reported good hearing was associated with the low reported use of hearing aids.