Miracle-dz/UniFAR-FTUs huggingface dataset:
Controlled and targeted drug delivery strategies towards intraperiodontal pocket diseases

Advances in the understanding of the aetiology, epidemiology, pathogenesis and microbiology of periodontal pocket flora have revolutionized the strategies for the management of intraperiodontal pocket diseases. Intra‐pocket, sustained release, drug delivery devices have been shown to be clinically effective in the treatment of periodontal infections. Several degradable and non‐degradable devices are under investigation for the delivery of antimicrobial agents into the periodontal pocket including non‐biodegradable fibres, films (biodegradable and non‐biodegradable), bio‐absorbable dental materials, biodegradable gels/ointments, injectables and microcapsules. With the realization that pocket bacteria accumulate as biofilms, studies are now being directed towards eliminating/killing biofilm concentrations rather than their planktonic (fluid phase) counterparts. Intraperiodontal pocket drug delivery has emerged as a novel paradigm for the future research. Similarly, bioadhesive delivery systems are explored that could significantly improve oral therapeutics for periodontal disease and mucosal lesions. A strategy is to target a wide range of molecular mediators of tissue destruction and hence arrest periodontal disease progression. Research into regenerating periodontal structures lost as a result of disease has also shown substantial progress in the last 25 years.
Effects of Redox Potential and Hydroxide Inhibition on the pH Activity Profile of Fungal Laccases*

The electronic absorption spectrum, susceptibility to fluoride inhibition, redox potential, and substrate turnover of several fungal laccases have been explored as a function of pH. The laccases showed a single spectrally detectable acid-base transition at pH 6-9 and a fluoride inhibition that diminished by increased pH (indicating a competition with hydroxide inhibition). Relatively small changes in the redox potentials (≤0.1 V) of laccase were observed over the pH 2.7-11. Under the catalysis of laccase, the apparent oxidation rates (kcat and kcat/Km) of two nonphenolic substrates, potassium ferrocyanide and 2,2′-azinobis-(3-ethylbenzthiazoline-6-sulfonic acid),decreased monotonically as the pH increased. In contrast, the apparent oxidation rates (kcat and kcat/Km) of three 2,6-dimethoxyphenols (whose pKa values range from 7.0 to 8.7) exhibited bell-shaped pH profiles whose maxima were distinct for each laccase but independent of the substrate. By correlating these pH dependences, it is proposed that the balance of two opposing effects, one generated by the redox potential difference between a reducing substrate and the type 1 copper of laccase (which correlates to the electron transfer rate and is favored for a phenolic substrate by higher pH) and another generated by the binding of a hydroxide anion to the type 2/type 3 coppers of laccase (which inhibits the activity at higher pH), contributes to the pH activity profile of the fungal laccases.
Pseudoword and Real Word Memory in Unilateral Temporal Lobe Epilepsy

Recognition memory for pronounceable pseudowords (PWs), real words, and degraded photographs of unfamiliar faces, was examined in 45 patients with unilateral temporal lobe epilepsy (TLE), before and after Anterior Temporal Lobectomy, to test predictions from two accounts of hemispheric differences in memory functioning: (1) The ‘material-specific’ account predicts that left TLE (LTLE) patients would be impaired in memory for both familiar (real words) and unfamiliar (PWs) verbal stimuli, while memory for novel complex visual stimuli (unfamiliar faces) would be impaired in right TLE (RTLE) patients. (2) The ‘familiarity’ account predicts that memory for familiar stimuli (such as words) will be impaired in LTLE patients, while memory for both linguistic and nonlinguistic unfamiliar stimuli should be disrupted in RTLE patients. Results were consistent with the ‘material-specific’ hypothesis suggesting that both familiar and unfamiliar linguistic stimuli are processed for memory in the left medial temporal lobe (MTL), whereas unfamiliar nonverbal stimuli are processed for memory in the right MTL.
Getting ready for reading: a follow-up study of inner city second language learners at the end of Key Stage 1.

BACKGROUND A previous study (Stuart, 1999) showed that early phoneme awareness and phonics teaching improved reading and spelling ability in inner-city schoolchildren in Key Stage 1, most of whom were learning English as a second language. AIMS The present study, a follow-up of these children at the end of Key Stage 1, addresses four main questions: (1) Are these improvements maintained to the end of Key Stage 1? (2) Are different patterns of cognitive process evident in the word recognition skills of phonics trained versus untrained children? (3) Do the phonics trained children now also show a significant advantage in reading comprehension? (4) Are there differences in amount of reading, in self-concept as readers and in oral vocabulary development between phonics trained and untrained children? Relationships between reading and spelling ages and Key Stage 1 SATs levels are also explored. SAMPLE Data are reported from 101 seven-year-olds (85 of whom were second language learners) remaining from the original 112 children reported on previously. METHOD Children were tested on four standardized tests of reading, spelling and vocabulary, and on a further six experimental tests of phoneme segmentation, grapheme-phoneme correspondence knowledge, regular, exception and nonword reading, author recognition and reading self-concept. RESULTS Lasting influences of early phoneme awareness and phonics teaching on phoneme awareness, grapheme-phoneme correspondence knowledge, word reading and spelling were found. Part of the previously untrained group had now received structured phonics teaching, and were therefore treated as a third (late trained) group. Early and late-trained groups showed similar levels of attainment and similar cognitive processing patterns, which were different from the untrained group. However, there were no influences of training on reading comprehension, self-concept or oral vocabulary. CONCLUSIONS Early phoneme awareness and phonics training efficiently accelerates the word recognition and spelling skills of first and second language learners alike. However, this is not sufficient to bootstrap the development of language comprehension in the second language learners. Further research is needed into the kinds of language teaching that will best develop their oral and written language comprehension.
Nerve structures at risk in the plantar side of the foot during anterior tibial tendon transfer: a cadaver study.

BACKGROUND Anterior tibial tendon transfer is a common procedure for treatment of clubfoot recurrence. Fixation of the tendon usually includes passing the tendon through the lateral cuneiform. Drilling the bone and passing sutures through the plantar aspect of the foot may cause neurovascular damage. METHODS Anterior tibial tendon transfer was performed through the lateral cuneiform in twelve cadaveric limbs. Drill holes were made perpendicular to the lateral cuneiform surface (group A), made perpendicular to the weight-bearing surface (group B), inclined 15° in the frontal and sagittal planes (group C), or aimed at the middle of the plantar aspect of the foot (group D). Two unmodified Keith needles and two blunted Keith needles were each passed ten times per foot. A dissection was performed. The average distance from the drill hole to the nerve structures and the number of punctures of nerve structures were reported. RESULTS In group A, the drill hole was 1.7 mm from a medial plantar nerve branch and 5 mm from the nerve bifurcation. In group B, the hole was 0.3 mm from a branch of the lateral plantar nerve and 25.3 mm from the lateral plantar nerve bifurcation. The drill hole in group C was 1.7 mm from the lateral plantar nerve bifurcation. In group D, the drill direction resulted in an inclination of 22° in the frontal plane and 4° in the sagittal plane. The drill exited 7.7 mm from a medial plantar nerve branch and 4.3 mm from a lateral plantar nerve branch. The medial and lateral plantar nerve bifurcations were at a distance of 13 mm and 14.7 mm, respectively, from the drill hole in group D. Unmodified Keith needles punctured nerve structures twelve times in group A, twenty times in group B, six times in group C, and once in group D. Use of blunted Keith needles resulted in no nerve punctures. CONCLUSIONS When anchoring the transferred anterior tibial tendon in the lateral cuneiform for the treatment of clubfoot recurrence, the drill should be aimed at the middle of the plantar surface of the foot to minimize the risk of nerve damage. Passing the sutures with a blunt needle might prevent damage to nerves or vessels when anterior tibial tendon transfer to the lateral cuneiform is performed for the treatment of clubfoot recurrence.
Microcystic Adnexal Carcinoma: An Immunohistochemical Comparison With Other Cutaneous Appendage Tumors

† Since its initial description, microcystic adnexal carcinoma (MAC) of the skin has been controversial. In particular, it features keratin production of the type seen in some pilar neoplasms, and has been thought to pursue partial follicular differentiation. Diagnostically, MAC may be difficult to separate from desmoplastic trichoepithelioma (DTE) in superficial biopsy specimens. We studied 12 MACs, 22 malignant eccrine acrospiromas, 7 sudoriferous syringometaplasias, 6 syringomas, 5 DTEs, and 40 other benign pilar neoplasms immuno-histochemically. Paraffin sections and antibodies to "hard" (pilar) keratins, epithelial membrane antigen (EMA), carcinoembryonic antigen (CEA), Leu-M1, and S 100 protein were employed. The MACs exhibited reactivity for hard keratin subclasses AE13 and AE14, EMA, CEA, and Leu-M1. Desmoplastic trichoepitheliomas expressed positivity for AE14, EMA, and Leu-M1 focally, but lacked the other specified markers. Syringomas and malignant acrospiromas displayed EMA, CEA, and AE14 reactivity, and 5 syringometaplastic lesions were AE14-reactive. Benign pilar tumors aside from DTEs were reactive only for AE13, AE14, or both. These data indicate that MAC exhibits an immunophenotype that is a "hybrid" of those seen in pure sweat glandular and follicular neoplasms, and suggest that it may indeed show combined pilar and sudoriferous differentiation. Based on these results, it also appears that immunohistochemical analysis may be useful in the diagnostic separation of MAC and DTE. (Arch Dermatol.1990; 126:189-194)
Does Implementing for an Objective Structure Clinical Examination Make A Difference

Introduction: Objective structure Clinical Examination (OSCE) is more sophisticated examination methods to assess competencies such as problem-solving abilities, critical thinking and communication skills, and has gained acceptance as a benchmark for clinical skills assessment. Aim: The main aim of this study was to implement an objective structure clinical examination (OSCE) of undergraduate nursing students enrolled in nursing administration course and examining student's perspectives for OSCE. Methods: The study was used experimental design, and conducted at the Nursing Administration Department, Faculty of Nursing, Mansoura University. The total number of the nursing students enrolled in the third academic year of 2011/2012 was (385) at the Nursing Administration Department, (179 students were experimental group who examined by OSCE as a new method for clinical exam and 209 students were control group, who examined by traditional method (checklist exam). A self-administered questionnaire was developed by Pierre et al., (2004) was adapted in this study. The questionnaire assesses OSCE evaluation, quality of performance testing, and student’s perception of validity and reliability. Result: The results of this study indicate that students examined by using OSCE had variation in their grades than students examined by traditional methods. OSCE has been accepted by the majority of nursing students as an evaluation tool for their clinical skills. Most students viewed OSCE as a fair assessment tool which covered a wide range of knowledge, minimized the chance of failing and highlighted areas of weaknesses. One third of students felt that OSCE was stressful and intimidating. Most students agreed that OSCE is objective tool in terms of a true measure of clinical skills and no statistical relationship were found regarding the students degrees of OSCE and their feedback.
Diversity of cultivated aerobic poly-hydrolytic bacteria in saline alkaline soils

Alkaline saline soils, known also as “soda solonchaks”, represent a natural soda habitat which differs from soda lake sediments by higher aeration and lower humidity. The microbiology of soda soils, in contrast to the more intensively studied soda lakes, remains poorly explored. In this work we investigate the diversity of culturable aerobic haloalkalitolerant bacteria with various hydrolytic activities from soda soils at different locations in Central Asia, Africa, and North America. In total, 179 pure cultures were obtained by using media with various polymers at pH 10 and 0.6 M total Na+. According to the 16S rRNA gene sequence analysis, most of the isolates belonged to Firmicutes and Actinobacteria. Most isolates possessed multiple hydrolytic activities, including endoglucanase, xylanase, amylase and protease. The pH profiling of selected representatives of actinobacteria and endospore-forming bacteria showed, that the former were facultative alkaliphiles, while the latter were mostly obligate alkaliphiles. The hydrolases of selected representatives from both groups were active at a broad pH range from six to 11. Overall, this work demonstrates the presence of a rich hydrolytic bacterial community in soda soils which might be explored further for production of haloalkalistable hydrolases.
Orbicules do not significantly contribute to the allergenic micro‐aerosol emitted from birch trees

References 1. Charpin D, Calleja M, Lahoz C, Pichot C, Waisel Y. Allergy to cypress pollen. Allergy 2004;34:293–301. 2. Hrabina M, Dumur JP, Sicard H, Viatte A, André C. Diagnosis of cypress pollen allergy: in vivo and in vitro standardization of a Juniperus ashei pollen extract. Allergy 2003;58:808–813. 3. van Ree R, Fernandez-Rivas M, Cuevas M, van Wijngaarden M, Aalberse RC. Pollenrelated allergy to peach and apple: an important role for profilin. J Allergy Clin Immunol 1995;95:726–734. 4. Pastorello EA, Ortolani C, Farioli L et al. Allergenic cross-reactivity among peach, apricot, plum and cherry in patients with oral allergy syndrome: an in vivo and in vitro study. J Allergy Clin Immunol 1994;94:699– 707. 5. Ferreira F, Hawranek T, Gruber P, Wopfner N, Mari A. Allergic crossreactivity: from gene to clinic. Allergy 2004;59:243–267.
Chinese acupuncture and moxibustion.

chinese acupuncture and moxibustion book read 11 reviews from the world s largest community for readers eligible for free super saving shipping fast a, moxibustion moxibustion is an ancient chinese method of applying gentle penetrating medicinal heat to specific locations of the body the technique involves burning dried wool like leaves of moxa herb artemisia vulgaris over the acupuncture points for positive therapeutic effects and unblocked qi flow, acupuncture and moxibustion are indispensable parts of traditiona chinses medicine in the prevention and control of disease since the founding of the people s republic of china these arts have beendeveloped and are highly regarded by the international academic community, what is moxibustion moxibustion is a form of heat therapy in which dried plant materials called moxa are burned on or very near the surface of the skin the intention is to warm and invigorate the flow of qi in the body and dispel certain pathogenic influences moxa is usually made from the dried leafy material of chinese mugwort artemesia argyi or a vlugaris but it can be made of other, chinese acupuncture and moxibustion 2010 3rd edition 1 jan 2010 by cheng xinhong hardcover £41 95 eligible for free uk delivery only 7 left in stock order soon more buying choices £37 99 18 used amp new offers 4 1 out of 5 stars 6 chinese acupuncture and moxibustion 31 dec 1999 by xinhong cheng, moxibustion can be used to cure diseases that medicine and acupuncture cannot cure get to know the mystical and traditional therapy moxibustion in this video posted by discover china on friday july 24 2015, what is moxibustion one of the methods of external treatment of traditional chinese medicine moxibustion involves burning the material made of cashmere near to skin on the specific acupuncture points the heat from the moxibustion transfers the medicine elements to the body through the acupuncture points to achieve medical result, acupuncture and moxibustion are indispensable parts of traditional chinese medicine in the prevention and control of disease since the founding of the peoples republic of china these arts have been developed and are highly regarded by the international academic community, acupuncture and moxibustion are an important invention of the chinese nation which originated as early as in the clan commune period of the primitive society the activities of human beings, chinese acupuncture amp moxibustion centre is an acupuncture and
Acute Kidney Injury (AKI) in perinatal asphyxia

Background: Acute kidney injury (AKI) is a common consequence of perinatal asphyxia,occurring in upto 56% of these neonates. It is important to recognize AKI in asphyxiated neonates to facilitate administration of appropriate fluids and electrolytes in order to improve their outcome. Objectives: To determine the incidence of AKI in asphyxiated neonates and to correlate the severity and type of AKI with Apgar score and severity of hypoxic ischemic encephalopathy (HIE). Methods: 75 neonates were enrolled – 50 asphyxiated and 25 healthy neonates. Renal functions were assessed using urine output, urine microscopy, biochemical parameters and sonography. The values obtained were correlated with the severity of HIE.Neonates with AKI were managed as per unit protocol. Results: Of the 50 asphyxiated neonates, 32 (64%) had AKI: 25 (78.12 %) neonates with pre-renal AKI and the remaining 7 (21.88 %) with intrinsic AKI. Out of the 32 asphyxiated neonates with AKI, 12 (37.5%) had oliguric AKI, while the remaining 20 (62.5%) had non-oliguric AKI. Levels of blood urea and serum creatinine were significantly higher in asphyxiated neonates as compared to healthy controls (p less than 0.001). Biochemical derangements correlated well with the severity of HIE and Apgar scores. Serum sodium and creatinine clearance showed significantly different values in asphyxiated babies compared to controls. There was no significant difference in the urine ouput in the control and study group. Sonographic abnormalities were seen most often in oliguric babies, and indicated bad prognosis. Mortality was higher in babies with oliguric AKI. Conclusions: Perinatal asphyxia is an important cause of neonatal AKI. Majority of the babies had non-oliguric AKI and responded well to fluid challenge. Abnormalities in the renal function correlates well with the severity of HIE. Intrinsic AKI, oliguria, hyponatremia,reduced creatinine clearance and abnormal sonographic scan suggest bad prognosis in neonatal AKI secondary to perinatal asphyxia.
Bandwidth Study of Recessed Probe Launch Variations for Broadband Measurement of Embedded PCB Structures

In this paper the recessed probe launch technique for measurement of embedded (internal) printed circuit board (PCB) structures such as striplines and vias (plated through holes) will be reviewed and its bandwidth will be studied in experiments. The recessed probe launch (RPL) uses high frequency microprobes in combination with a milling technique that removes upper board layers and exposes internal probing points. By providing direct access to the PCB layers of interest a broadband launch into embedded structures is thus provided. Here, measurements of different RPL designs show that reflections of less than -25 dB from DC up to 40 GHz can be achieved. First investigations show that this level of reflection is mostly due to a mismatched stripline impedance in the 52 Ohm range and not due to the recessed probe launch itself. Full-wave simulations are underway to corroborate the results obtained by measurements.
Not by bread alone': impact of a structured 90-minute play session on development of children in an orphanage.

BACKGROUND AND OBJECTIVES In developing countries, caring for the large number of babies in orphanages is very hard work. Whereas the physical needs of most of the children are met, play often gets neglected. Studies have repeatedly shown that babies in such institutionalized settings suffer from severe psychomotor retardation. The aim of this project was to develop an intervention programme of structured play. We hypothesized that such an intervention would result in acceleration of psychosocial development in otherwise healthy institutionalized children. DESIGN Prospective longitudinal. SETTING Mother Teresa's Orphanage, run by Missionaries of Charity. SUBJECT AND METHODS All 30 children in the orphanage aged 6 months-2.5 years, were assessed for their Motor, Mental and Social Quotients, using the Indian adaptation of Bailey's Scale of Infant Development(DASII) and the Vineland's Social Maturity Scale. A structured 'Regime of Play' was then built into the routine of the orphanage. A repeat developmental assessment was performed at the end of 3 months to assess the impact. RESULTS Out of the original cohort of 30, 19 children were available for post-intervention assessments. The remainder were adopted before their assessments. Their mean Motor Quotient rose from 63.7 to 81.7, mean Mental Quotient rose from 65.8 to 89.6 and the mean Social Quotient rose from 61.9 to 91.3, a gain of 18, 23 and 30 points respectively (p < 0.0001). There was also an overall change in the environment of the orphanage. Children became more active, playful, responsive and independent. Contrary to what caretakers assumed, their workload actually decreased. The responsiveness in the children awakened as a result of play, acted as a positive feedback for caretakers to continue the play sessions. CONCLUSIONS This study shows that short daily sessions of play can significantly improve the development of children in such institutions. It is vital to remember that children grow 'Not by Bread Alone'.