Miracle-dz/UniFAR-FTUs huggingface dataset:
Short-term outcome of laparoscopic cholecystectomy for benign gall bladder diseases in 76 dogs

Laparoscopic cholecystectomy (LC) is widely accepted as the standard treatment for benign gall bladder diseases in humans because it has proven to be less invasive and safer than are traditional methods. However, the efficacy of LC in dogs remains unclear. The present study aimed to examine the short-term outcome of LC for benign gall bladder diseases in dogs. We enrolled 76 consecutive dogs that underwent LC for benign gall bladder diseases at our hospital between April 2008 and October 2016. Dogs with jaundice, gall bladder ruptures, abdominal effusion, or extrahepatic biliary obstruction were not excluded from the indication. Factors including age, body weight, sex, clinical sign, disease, operative time, conversion to open surgery, perioperative complications, and postoperative hospital stay were investigated. The median age of the dogs was 11 years, and the median body weight was 5.4 kg. Fifty percent of the dogs exhibited no symptoms at the initial visit. Preoperative elevation of total bilirubin levels was observed in 16 dogs (21%). LC was successfully completed in 71 dogs (93%); the median operative time was 124 min. Although gall bladder ruptures were observed in 2 (2.6%) dogs, the operations were completed successfully. Three dogs (4.1%) had to be converted to open cholecystectomy and 2 (2.6%) underwent reoperation. Two dogs (2.6%) died intraoperatively and 2 (2.6%) died postoperatively. LC was a feasible, safe, and appropriate procedure considering the current operative indications for benign gall bladder diseases in dogs.
Slagtekvalitet og sygdomsfund hos økologiske slagtesvin

Et vaesentligt mal i produktionen af okologisk svinekod er at fa flest mulige slagtesvin godkendt efter de okologiske kvalitetskriterier. En godkendelse af slagtekroppen medforer den bedste afregning til producenten og opfylder forbrugerens onske om svinekod med lavt fedtindhold produceret pa en gris, der har haft et liv uden belastende sygdomme og skavanker.Okologiske svin skal foruden kravet til basisvaegt opfylde kvalitetskriterier for spaektykkelse, kodprocent i midterstykke og i slagtekroppen. Samtidig afstikker det okologiske regelsaet en raekke bestemmelser vedrorende genetik, opstaldning og fodring, der pavirker produktionen af svinene vaesentligt. Viden skabt i den traditionelle produktion kan derfor ikke altid overfores til den okologiske produktionsform. I den traditionelle slagtesvineproduktion i Danmark ses en systematisk variation i kodprocenten henover aret, idet der i sommerhalvaret opnas de hojeste kodindhold i slagtekroppene. Tilsvarende har flere danske opgorelser vist systematiske arstidsvariationer i forekomsten af brysthindear hos bade SPF-, MS- og konventionelle grise. Da stort set alle okologiske grise har en konventionel sundhedsstatus og overfores fra mark til abne staldanlaeg ved fravaenning eller senere, vil det vaere relevant at undersoge for tilsvarende arstidsvariationer. For at fa et bedre beslutningsgrundlag for tiltag, der kan medforer flere godkendte slagtesvin, blev der gennemfort analyser af slagtedata pa okologiske slagtesvin. Analyserne tog saerligt sigte pa at undersoge 1) forskelle relateret til slagtevaegt og kon, 2) forekomst af arstidsvariationer i slagtekvalitet og sygdomsforekomst og 3) forskelle mellem besaetninger i slagtekvalitet og sygdomsforekomst.
Esophageal cancer patients' information management: cross-cultural differences between Dutch and Italian patients in perceived quality of provided oncological information.

Esophageal cancer (EC) is the eight most common cancer worldwide with more than 450,000 new cases every year with the highest incidence in Asia and Africa (1,2). The prognosis remains generally poor, with a 5-year survival rate decreasing from 50% for localized tumors to 4% for metastatic disease (3).
Myeloid-derived suppressor cells inhibit T cell activation through nitrating LCK in mouse cancers

Significance Immune checkpoint blockade (ICB) to reinvigorate cytotoxic T lymphocytes using antibodies against CTLA4 or PD1 generates durable therapeutic responses in patients across a variety of cancer types. However, some cancers such as castration-resistant prostate cancer (CRPC) show overwhelming resistance to ICB. Here, we develop a nitroproteomic approach and uncover a potential mechanism for the immunotherapy resistance where a key protein for T cell activation, lymphocyte-specific protein tyrosine kinase (LCK), is nitrated and inactivated by myeloid-derived suppressor cell–generated reactive nitrogen species (RNS) in the resistant tumor. An agent that neutralizes RNS significantly sensitizes CRPC to ICB therapy in a mouse model. Therefore, our studies illuminate a clinical path hypothesis for combining ICB with RNS-reducing agents in the treatment of ICB-resistant cancers. Potent immunosuppressive mechanisms within the tumor microenvironment contribute to the resistance of aggressive human cancers to immune checkpoint blockade (ICB) therapy. One of the main mechanisms for myeloid-derived suppressor cells (MDSCs) to induce T cell tolerance is through secretion of reactive nitrogen species (RNS), which nitrates tyrosine residues in proteins involved in T cell function. However, so far very few nitrated proteins have been identified. Here, using a transgenic mouse model of prostate cancer and a syngeneic cell line model of lung cancer, we applied a nitroproteomic approach based on chemical derivation of 3-nitrotyrosine and identified that lymphocyte-specific protein tyrosine kinase (LCK), an initiating tyrosine kinase in the T cell receptor signaling cascade, is nitrated at Tyr394 by MDSCs. LCK nitration inhibits T cell activation, leading to reduced interleukin 2 (IL2) production and proliferation. In human T cells with defective endogenous LCK, wild type, but not nitrated LCK, rescues IL2 production. In the mouse model of castration-resistant prostate cancer (CRPC) by prostate-specific deletion of Pten, p53, and Smad4, CRPC is resistant to an ICB therapy composed of antiprogrammed cell death 1 (PD1) and anticytotoxic–T lymphocyte-associated protein 4 (CTLA4) antibodies. However, we showed that ICB elicits strong anti-CRPC efficacy when combined with an RNS neutralizing agent. Together, these data identify a previously unknown mechanism of T cell inactivation by MDSC-induced protein nitration and illuminate a clinical path hypothesis for combining ICB with RNS-reducing agents in the treatment of CRPC.
Electromagnetic Force and Vibration Analysis of Permanent-Magnet-Assisted Synchronous Reluctance Machines

This paper first studies the electromagnetic force and vibration characteristics of the permanent-magnet-assisted synchronous reluctance machines (PM-SynRMs). First, an analytical method to calculate the radial force is proposed based on the Maxwell stress tensor method. The temporal and spatial orders of radial force are obtained by two-dimensional fast Fourier transform, then the combination of stator slots and rotor virtual slots of PM-SynRMs is proposed to give a guideline for the initial design of PM-SynRM to achieve low noise and vibration. A PM-SynRM is designed and a multiphysics model for electromagnetic vibration is established. The radial and tangential force under no-load and load conditions are calculated by finite element method, and then compared with the analysis results. Modal analysis is implemented to capture the structural parameters of the stator. Based on the proposed multiphysics model, the vibration responses under both no-load and load conditions are calculated through modal superposition method. Finally, a PM-SynRM is built and vibration test is performed to investigate its vibration characteristics.
Absence of AIF1L contributes to cell migration and a poor prognosis of breast cancer

Background Breast cancer is the most common fatal cancer in women worldwide. Previous studies have demonstrated that allograft inflammatory factor 1 like (AIF1L) plays a key role in mammary tumorigenesis, although the mechanism involved remains unclear. Purpose The purpose of this study was to assess the clinicopathological and prognostic significance of AIF1L expression levels and biological function in breast cancer. Patients and methods We used immunohistochemistry to detect the expression of AIF1L in breast cancer. We also analyzed the expression of AIF1L in breast cancer using the Cancer Genome Atlas (TCGA) cohort and the Cancer Cell Line Encyclopedia (CCLE). Furthermore, both in vitro assays were used to determine the effect of AIF1L on malignant behavior in breast cancer cells. Results We detected AIF1L expression in tissue microarrays through immunohistochemistry and found that protein expression was significantly lower in BC tissues (28.6%, 82/287) compared to tumor-adjacent tissues (58.3%, 28/48) (P=0.007). Kaplan-Meier survival analysis revealed that disease-specific survival in BC patients with low AIF1L protein expression was significantly poorer compared to normal controls (P=0.040). In the TCGA cohort, the AIF1L gene was downregulated and hypermethylated in tumor samples compared to normal controls. Bioinformatics analysis using CCLE predicted potential biological functions of AIF1L related to tight junctions, cell junctions and focal adhesion. Ectopic expression of AIF1L suppressed MDA-MB-231 migration and invasion. Further evidence confirmed that AIF1L overexpression suppressed cell spreading, altered cell shape and decreased protrusion formation, which was correlated with decreased focal adhesion kinase (FAK) and RhoA expression. Conclusion These findings suggest that AIF1L is a potential prognostic biomarker that plays a vital role in regulating the cytoskeleton in breast cancer.
Multi-Stage Lung Cancer Detection and Prediction Using Multi-class SVM Classifie

Recognition and prediction of lung cancer in the earliest reference point stage can be very useful to improve the survival rate of patients. But diagnosis of cancer is one the major challenging task for radiologist. For detecting, predicting and diagnosing lung cancer, an intelligent computer-aided diagnosis system can be very much useful for radiologist. This paper proposed an efficient lung cancer detection and prediction algorithm using multi-class SVM (Support Vector Machine) classifier. Multi-stage classification was used for the detection of cancer. This system can also predict the probability of lung cancer. In every stage of classification image enhancement and segmentation have been done separately. Image scaling, color space transformation and contrast enhancement have been used for image enhancement. Threshold and marker-controlled watershed based segmentation has been used for segmentation. For classification purpose, SVM binary classifier was used. Our proposed technique shows higher degree of accuracy in lung cancer detection and prediction
Percutaneous Cannulation for Extracorporeal Life Support in Severely and Morbidly Obese Patients

Background: Extracorporeal life support systems are well-established devices for treating patients with acute cardiopulmonary failure. Severe or morbid obesity may result in complications such as limb ischemia, bleeding, unsuccessful cannulation, or infection at the cannulation sites. This article reports on our experience with cannulation and associated complications in severely and morbidly obese patients. Methods: Between January 2006 and September 2016, 153 severely or morbidly obese patients with a body mass index >35 kg/m2 were cannulated percutaneously for extracorporeal life support at our center. Among those, 115 patients were treated with venovenous extracorporeal membrane oxygenation (VV ECMO) for acute lung failure and 38 patients with venoarterial extracorporeal membrane oxygenation (VA ECMO) for cardiogenic shock. Complications related to percutaneous access and long-term follow-up were analyzed retrospectively. Primary focus was on the success of cannulation, outcome, thrombosis, bleeding, limb ischemia, and infection at the cannulation site. Normal-weight patients receiving extracorporeal life support served as control. Results: Percutaneous cannulation was successfully performed in all patients. Eighty-five (74%) patients were weaned from VV ECMO and 20 (52%) patients were weaned from VA ECMO. Limb ischemia requiring surgical intervention occurred in 5 (3%) patients, bleeding in 7 (5%) patients, and wound infection in 3 (2%) patients. In all other patients, decannulation was uneventful. These data as well as the long-term survival rates were comparable to those of normal-weight patients (P > .05). Conclusion: Percutaneous vessel cannulation for extracorporeal life support systems is generally feasible. Therefore, percutaneous cannulation may well be performed in severely and morbidly obese patients. Patient outcome rather depends on appropriate support than on anatomy.
Gender Differences in Reading and Writing Achievement: Evidence From the National Assessment of Educational Progress (NAEP)

A frequently observed research finding is that females outperform males on tasks of verbal and language abilities, but there is considerable variability in effect sizes from sample to sample. The gold standard for evaluating gender differences in cognitive ability is to recruit a large, demographically representative sample. We examined 3 decades of U.S. student achievement in reading and writing from the National Assessment of Educational Progress to determine the magnitude of gender differences (N = 3.9 million), and whether these were declining over time as claimed by Feingold (1988). Examination of effect sizes found a developmental progression from initially small gender differences in Grade 4 toward larger effects as students progress through schooling. Differences for reading were small-to-medium (d = −.32 by Grade 12), and medium-sized for writing (d = −.55 by Grade 12) and were stable over the historical time. Additionally, there were pronounced imbalances in gender ratios at the lower left and upper right tails of the ability spectrum. These results are interpreted in the context of Hyde’s (2005) gender similarities hypothesis, which holds that most psychological gender differences are only small or trivial in size. Language and verbal abilities represent one exception to the general rule of gender similarities, and we discuss the educational implications of these findings.
What if consciousness has no function?

Abstract An implicitly dualist or Cartesian materialist theory of consciousness is proposed without citing the many well-known problems with such theories. A function for consciousness is proposed with no reference to the possibility that “consciousness itself” has no function of its own. The theory builds on proposed “subset consensus” and “integration consensus” when in the literature there is no such consensus on these issues.
Oasis: A Mobile Cyber–Physical System for Accessible Location Exploration

Users roaming cellular signal coverage with their mobile devices essentially form a mobile cyber–physical system (CPS). By modeling cyber human mentality and physical signal coverage, as well as their interplay, user mobility can be leveraged to improve users’ mobile experience with limited wireless bandwidth. Through a real-world case study, we observed that numerous “null zones” and “hot zones” exist in cellular signal coverage areas, where mobile devices cannot obtain sufficiently high data rates for delay-sensitive applications. Over one third of the locations in a crowded area could have weak signal coverage and low bandwidth shares, resulting in poor mobile connectivity experience. This paper considers the practicality of a mobile CPS called Oasis, which guides users to leave those zones and move to nearby locations with better mobile experience. To realize the system, we model and maximize a user’s willingness to travel to another location, where the willingness involves the compound impact of the travel distance and the improved perceptual quality. We also develop a prototype system that creates a feedback control loop to allow self-adaptation to users’ needs. To evaluate the efficacy, we conducted a series of experiments based on the real data collected in downtown Taipei, Taiwan. The results demonstrate that our mobile CPS can further reduce the average distance per unit of quality improvement achieved with OpenSignalMaps by about 80%, and motivate further research.
Bottlenose dolphins can understand their partner's role in a cooperative task

In recent decades, a number of studies have examined whether various non-human animals understand their partner's role in cooperative situations. Yet the relatively tolerant timing requirements of these tasks make it theoretically possible for animals to succeed by using simple behavioural strategies rather than by jointly intended coordination. Here we investigated whether bottlenose dolphins could understand a cooperative partner's role by testing whether they could learn a button-pressing task requiring precise behavioural synchronization. Specifically, members of cooperative dyads were required to swim across a lagoon and each press their own underwater button simultaneously (within a 1 s time window), whether sent together or with a delay between partners of 1–20 s. We found that dolphins were able to work together with extreme precision even when they had to wait for their partner, and that their coordination improved over the course of the study, with the time between button presses in the latter trials averaging 370 ms. These findings show that bottlenose dolphins can learn to understand their partner's role in a cooperative situation, and suggest that the behavioural synchronization evident in wild dolphins' synchronous movement and coordinated alliance displays may be a generalized cognitive ability that can also be used to solve novel cooperative tasks.
Antituberculosis Drug-induced Liver Injury in Children: Incidence and Risk Factors During the Two-month Intensive Phase of Therapy

Background: As one of the most frequent and serious adverse reactions during tuberculosis (TB) treatment, antituberculosis drug-induced liver injury (ATLI) in children has been studied insufficiently compared with adults. We aimed to determine the incidence and risk factors of ATLI in children during the first 2 months of TB therapy. Methods: A total of 41 children with TB and treated with first-line anti-TB drugs were prospectively followed-up for the development of ATLI. Liver function tests were performed at baseline and after 2 weeks of therapy. Subsequent tests were conducted at 4, 6 and 8 weeks if the initial 2-week measurement was abnormal or if symptoms of hepatotoxicity were reported. Results: ATLI was detected in 11 (27%) patients within 14 to 42 days from the start of therapy, with most of them (54%) occurred after 2 weeks. TB treatment was stopped immediately in 6 of 11 patients who developed ATLI, and no recurrent hepatotoxicity after drug reintroductions in these patients. Univariate analysis showed that ATLI was significantly associated with TB meningitis (P < 0.01), hypoalbuminemia (P < 0.05) and hepatotoxic comedications (P < 0.01). Age, sex, nutritional status, HIV status and baseline liver function abnormalities were not associated with ATLI. Multivariate analysis identified hypoalbuminemia and hepatotoxic comedications (both P < 0.1) tend to be independently associated with ATLI. Conclusions: Children with hypoalbuminemia and use of hepatotoxic comedications are suggested to be monitored closely for the development of ATLI.
Sensory Processing Phenotypes in Fragile X Syndrome

Fragile X syndrome (FXS) is a neurodevelopmental disorder that causes intellectual disability. It is a leading known genetic cause of autism. In addition to cognitive, social, and communication deficits, humans with FXS demonstrate abnormal sensory processing including sensory hypersensitivity. Sensory hypersensitivity commonly manifests as auditory, tactile, or visual defensiveness or avoidance. Clinical, behavioral, and electrophysiological studies consistently show auditory hypersensitivity, impaired habituation to repeated sounds, and reduced auditory attention in humans with FXS. Children with FXS also exhibit significant visuospatial impairments. Studies in infants and toddlers with FXS have documented impairments in processing texture-defined motion stimuli, temporal flicker, perceiving ordinal numerical sequence, and the ability to maintain the identity of dynamic object information during occlusion. Consistent with the observations in humans with FXS, fragile X mental retardation 1 (Fmr1) gene knockout (KO) rodent models of FXS also show seizures, abnormal visual-evoked responses, auditory hypersensitivity, and abnormal processing at multiple levels of the auditory system, including altered acoustic startle responses. Among other sensory symptoms, individuals with FXS exhibit tactile defensiveness. Fmr1 KO mice also show impaired encoding of tactile stimulation frequency and larger size of receptive fields in the somatosensory cortex. Since sensory deficits are relatively more tractable from circuit mechanisms and developmental perspectives than more complex social behaviors, the focus of this review is on clinical, functional, and structural studies that outline the auditory, visual, and somatosensory processing deficits in FXS. The similarities in sensory phenotypes between humans with FXS and animal models suggest a likely conservation of basic sensory processing circuits across species and may provide a translational platform to not just develop biomarkers but also to understand underlying mechanisms. We argue that preclinical studies in animal models of FXS can facilitate the ongoing search for new therapeutic approaches in FXS by understanding mechanisms of basic sensory processing circuits and behaviors that are conserved across species.
Mycoplasma hominis empyema following caesarean section

Mycoplasma hominis as a cause of empyema is rare. We report a case of empyema caused by M. hominis following a caesarean section. A 28‐year‐old woman at 39 weeks and one day of pregnancy was admitted to our hospital and underwent an emergency caesarean section because of premature rupture of membranes. On postoperative day 2, she developed a fever, and flomoxef was administered. A pleural effusion developed on the right side. A diagnosis of empyema was made, and sulbactam/ampicillin was administered. However, the patient’s clinical condition did not improve. Numerous small pinpoint colonies, which did not yield visible bacteria on a Gram stain, were observed on a plate of pleural fluid culture, and M. hominis empyema was suspected. Based on this result, antibiotic therapy was switched to clindamycin, and the patient’s clinical condition improved rapidly. M. hominis was detected in the pleural fluid by polymerase chain reaction (PCR) assay. M. hominis should be considered a causative pathogen for empyema following a caesarean section.