Miracle-dz/UniFAR-FTUs huggingface dataset:
Psoriasis and cancer. An Australian/New Zealand narrative

Patients with psoriasis have an increased risk of cancer, which may be due to impaired immune surveillance, immune modulatory treatments, chronic inflammation and/or co‐risk factors such as obesity. The increase in treatment‐independent solid cancers, including urinary/bladder cancers, oropharynx/larynx, liver/gallbladder and colon/rectal cancers, seem to be linked to alcohol and smoking. Lung cancer and nonmelanoma skin cancer are also increased in patients with psoriasis. The risk of nonmelanoma skin cancer increases with age and severity of psoriasis. It is also higher in men, particularly for squamous cell carcinoma, which may reflect previous exposure to PUVA and/or ciclosporin. The risk of cutaneous T‐cell lymphoma is substantially higher in patients with moderate‐to‐severe psoriasis. Biologic therapies are independently associated with a slight increase risk of cancer, but this is less than ciclosporin, with the risk confounded by disease severity and other co‐risk factors. The risk of cancer from low‐dose methotrexate is likely minimal. In contrast, acitretin is likely protective against a variety of solid and haematological malignancies. The data on small molecule therapies such as apremilast are too immature for comment, although no signal has yet been identified. The decision whether to stop psoriasis immune modulatory treatments following a diagnosis of cancer, and when to resume, needs to be considered in the context of the patients’ specific cancer. However, there is no absolute need to stop any treatment other than possibly ciclosporin, unless there is a concern over an increased risk of serious infection or drug–drug interaction with cancer‐directed therapies, including radiotherapy.
Angiotensin receptor neprilysin inhibitors in older patients with heart failure

Heart failure affects approximately 1.5% of the adult population in developed countries and the prevalence rises to almost 10% in those over 70 years, a progressively increasing subset of the population.1 2 Sacubitril/Valsartan (an angiotensin receptor/neprilysin inhibitor—ARNi) was introduced as a novel agent for heart failure in 2014. Should this novel agent be tolerated and prove efficacious in older patients with heart failure? ACE inhibitors were first reported as beneficial more than 25 years ago and have been the mainstay of therapy for heart failure since then.3 A combination of ACE inhibitors with beta blockers4 and aldosterone antagonists5 has contributed to best medical management during the intervening period. Therapeutic manipulation of the third neurohormonal system involving the natriuretic peptides has been evaluated over many years. While these peptides have been reported to cause effects such as vasodilation, suppression of aldosterone secretion, natriuresis and diuresis, all of which should be beneficial in heart failure, early studies in humans resulted in disappointing outcomes. For example, neprilysin inhibitors given alone did not produce clinically beneficial effects probably because neprilysin is also responsible for the breakdown of other polypeptide vasoconstrictors such as angiotensin II, thus negating any beneficial effects.6 Moreover the combination of neprilysin inhibitors and ACE inhibitors was demonstrated as potentially detrimental due to the increased propensity to angiooedema probably related to excess bradykinin (also degraded by neprilysin) levels.7 8 When the PARADIGM-HF study prospectively compared Sacubitril/Valsartan with an ACE inhibitor (enalapril), with a view to determining the impact of those therapies on mortality and morbidity in heart failure, there was a significant reduction in cardiovascular and all-cause mortality.9 Moreover, there was a significant diminution in the rate of hospitalisation with worsening heart failure and these effects are detailed in table 1. View this table: Table 1 Positive …
Sustainability of Pain Relief After Corneal Collagen Cross‐Linking in Eyes With Bullous Keratopathy

Purpose: This study aimed to examine the efficiency and sustainability of pain relief produced by corneal collagen cross‐linking (CXL) in eyes with bullous keratopathy (BK) and to explore the histopathological changes in the stroma by using in vivo confocal microscopy. Design: Prospective observational case series. Methods: Fourteen eyes of 14 consecutive BK patients were treated with CXL with dehydration of the corneal stroma and followed up for 1 year after treatment. The best‐corrected visual acuity (BCVA), intraocular pressure, and central corneal thickness (CCT) were examined before the treatments and up to 1 year after. The intensity and frequency of pain were graded on a scale from 0 (minimum) to 10 (maximum). At 1 year after CXL, the corneal stroma was observed using confocal microscopy at depths of 100 and 200 &mgr;m. Results: The BCVA and CCT did not change significantly. The mean pain intensity and frequency scores were 5.6 and 4.6, respectively, before treatment. The intensity score significantly decreased at 1 week and onward, and the frequency score significantly decreased over 6 months after treatment. The confocal microscopy images showed that keratocytes and nerve fibers were rare and sparsely distributed in the stroma 1 year after CXL. Conclusions: The CXL efficiently relieved pain due to BK for 1 year after treatment. The in vivo confocal microscopy observations and unchanged CCT demonstrated that the persistence of pain relief was due to the inadequate regeneration of nerve fibers in the corneal stroma.
Real-Time Multimedia Social Event Detection in Microblog

Detecting events from massive social media data in social networks can facilitate browsing, search, and monitoring of real-time events by corporations, governments, and users. The short, conversational, heterogeneous, and real-time characteristics of social media data bring great challenges for event detection. The existing event detection approaches rely mainly on textual information, while the visual content of microblogs and the intrinsic correlation among the heterogeneous data are scarcely explored. To deal with the above challenges, we propose a novel real-time event detection method by generating an intermediate semantic level from social multimedia data, named microblog clique (MC), which is able to explore the high correlations among different microblogs. Specifically, the proposed method comprises three stages. First, the heterogeneous data in microblogs is formulated in a hypergraph structure. Hypergraph cut is conducted to group the highly correlated microblogs with the same topics as the MCs, which can address the information inadequateness and data sparseness issues. Second, a bipartite graph is constructed based on the generated MCs and the transfer cut partition is performed to detect the events. Finally, for new incoming microblogs, incremental hypergraph is constructed based on the latest MCs to generate new MCs, which are classified by bipartite graph partition into existing events or new ones. Extensive experiments are conducted on the events in the Brand-Social-Net dataset and the results demonstrate the superiority of the proposed method, as compared to the state-of-the-art approaches.
Observer-Based Adaptive Fuzzy Fault-Tolerant Optimal Control for SISO Nonlinear Systems

This paper investigates adaptive fuzzy output feedback fault-tolerant optimal control problem for a class of single-input and single-output nonlinear systems in strict feedback form. The considered nonlinear systems contain unknown nonaffine nonlinear faults and unmeasured states. Fuzzy logic systems are used to approximate cost function and unknown nonlinear functions, respectively. It is assumed that the states of the systems to be controlled are unmeasurable, thus an adaptive state observer is developed. To solve the nonaffine nonlinear fault control design problem, filtered signals are introduced into the adaptive backstepping control design procedures, and in the framework of adaptive critic technique and fault-tolerant control technique, a novel adaptive fuzzy fault-tolerant optimal control scheme is developed. The stability of the closed-loop system is proved by using Lyapunov stability theory. The simulation results verify the effectiveness of the proposed control strategy.
5’-AMP-Activated Protein Kinase Regulates Goat Sperm Functions via Energy Metabolism In Vitro

Background/Aims: ATP is essential for mammalian sperm to survive and maintain fertilizing capacity. AMP-activated protein kinase (AMPK) is a sensor of cellular energy status. The aims of the present study were to explore the localization of AMPK in goat sperm and to investigate whether and how AMPK regulates sperm functions in vitro. Methods: Sperm were treated with AMPK modulators (AICAR, metformin and Compound C) during incubation. Sperm motility was assessed with a computer-assisted spermatozoa analysis system (CASA). Membrane integrity, acrosome reaction and mitochondrial membrane potentials were detected by SYBR-14/PI, FITC-PNA and JC-1 staining, respectively. And the lactate content, ATP content, AMPK activity, activity of pyruvate kinase (PK) and lactate dehydrogenase (LDH) were also measured with the commercial assay kits. Immunofluorescence staining was used to analyze the distribution of PK, LDH, AMPK and phospho-Thr172-AMPK in sperm. The role of AMPK was further studied during induction of capacitation and acrosome reaction. Results: We found that AMPKα was localized in the entire acrosomal region, the midpiece and the flagellum, while the phospho-Thr172-AMPK was distributed in the head, the midpiece and flagellum. Activation of AMPK by AICAR and metformin significantly improved sperm motility, membrane integrity and acrosome reaction, largely maintained sperm mitochondrial membrane potentials, lactate content and ATP content, and enhanced the activity of AMPK, PK and LDH, whereas inhibition by Compound C triggered the converse effects. Moreover, PK was localized in the acrosomal area and the midpiece, while LDH was distributed in the tail. Induction of capacitation and acrosome reaction led to AMPK phosphorylation. AMPK phosphorylation regulated the activity of energetic enzymes. Conclusion: This study for the first time provides evidence that AMPK governs goat sperm functions through energy metabolism in vitro. This finding will help to improve assisted reproductive techniques in goats and the other species.
Characterization of fibroblast growth factor 1 in obese children and adolescents

Background Fibroblast growth factor 1 (FGF1) can regulate glucose and lipid metabolism in obese mice. Serum FGF1 has increased in type 2 diabetes mellitus adults and correlated with BMI. This study aimed to indicate conventional weight loss effects on FGF1 in obese children and adolescents. Materials and methods Clinical and metabolic parameters of 88 lean and obese individuals (ages 5–15 years) and 39 obese individuals followed with 6 months of lifestyle intervention were collected. Serum FGF1 levels were detected through enzyme-linked immunosorbent assays. Results FGF1 levels were increased in obese individuals. Serum FGF1 levels were significantly correlated with BMI and waist circumferences (r = 0.377, P = 0.012; r = 0.301, P = 0.047, respectively). Multivariate stepwise linear regression analyses showed that FGF1 levels were significantly correlated with HbA1c and HOMA-IR (β = 0.371, P = 0.008; β = 0.323, P = 0.021, respectively). Weight loss (2.3 ± 0.1 kg) was accompanied by a significant reduction of circulating FGF1 levels (7.2 ± 0.4 pg/mL). Changes in FGF1 were significantly correlated with changes in fasting glucose, HOMA-IR and low-density lipoprotein cholesterol (β = 0.277, P = 0.020; β = 0.474, P < 0.001; β = 0.320, P = 0.008, respectively). Conclusion FGF1 was related to increased risk of insulin resistance in obese children and adolescents. Serum FGF1 reduced after weight loss in obese individuals and was associated with the improvement of insulin resistance. Changes in serum FGF1 were more correlated with insulin resistance than changes in obesity per se.
A systematic review of advanced endoscopy-assisted lithotripsy for retained biliary tract stones: laser, electrohydraulic or extracorporeal shock wave

Abstract Background When conventional endoscopic treatment of bile duct stones is impossible or fails, advanced endoscopy-assisted lithotripsy can be performed by electrohydraulic lithotripsy (EHL), laser lithotripsy, or extracorporeal shock wave lithotripsy (ESWL). No systematic review has compared efficacy and safety between these techniques. Methods A systematic search was performed in PubMed, the Cochrane Library, and EMBASE for studies investigating EHL, laser lithotripsy, and ESWL in patients with retained biliary tract stones. Results After screening 795 studies, 32 studies with 1969 patients undergoing EHL (n = 277), laser lithotripsy (n = 426) or ESWL (n = 1266) were included. No randomized studies were available. Although each advanced lithotripsy technique appeared to be highly effective, laser lithotripsy had a higher complete ductal clearance rate (95.1 %) than EHL (88.4 %) and ESWL (84.5 %; P < 0.001). In addition, a higher stone fragmentation rate was reported for laser lithotripsy (92.5 %) than for EHL (75.5 %) and ESWL (89.3 %; P < 0.001). The post-procedural complication rate was significantly higher for patients treated with EHL (13.8 %) than for patients treated with ESWL (8.4 %) or laser lithotripsy (9.6 %; P = 0.04). Data on the recurrence rate of the biliary tract stones were lacking. Conclusion This systematic review revealed that laser lithotripsy appeared to be the most successful advanced endoscopy-assisted lithotripsy technique for retained biliary tract stones, although randomized studies are lacking.
Recruiting Older Adults With Functional Difficulties Into a Community-Based Research Study: Approaches and Costs

The CAPABLE (Community Aging in Place, Advancing Better Living for Elders) trial in Baltimore City tested whether an interdisciplinary team of occupational therapists, nurses, and handymen reduces disability and health expenditures in community-dwelling older adults with functional difficulties. This study describes methods and associated costs of recruiting 300 low-income, cognitively intact, older adults with functional difficulties into this study. Sources of participant enrollment included direct mailings (35%), government program referrals (19%), community-based organizations (16%), ambassador referrals (15%), and media (4%). Fifty six (30%) of 187 older adults referred through government organizations were enrolled, while 49 (7.6%) of 648 referred from community-based organizations were enrolled. Total recruitment costs were US$81,453.12. Costs per participant for mailings, media, ambassadors, and community-based organizations were respectively US$745.10, US$256.82, US$22.28, and US$1.00. Direct mailings yielded the most participants but was the most costly method per participant. Ambassadors were least expensive and may offer a low-cost addition to community outreach for recruitment of older adults into research.
BitMapper2: A GPU-Accelerated All-Mapper Based on the Sparse q-Gram Index

The explosive growth of next-generation sequencing (NGS) read datasets drives a need for new faster read mappers. One class of read mappers, called all-mappers, is designed to identify all mapping locations of each read. Many all-mappers have been developed over the past few years, but they are either time-consuming or memory-consuming. Here, we present BitMapper2, a GPU-accelerated read mapper that reports all mapping locations of NGS reads. To make full use of the parallel processing capability of GPUs, BitMapper2 proposes the sparse q-gram index, which reduces the memory requirement and the data transfer time between GPU and CPU. We also design the filtration part and the verification part of BitMapper2 specifically for the architecture of GPU. In addition, BitMapper2 is still time-efficient and memory-efficient even if there is no GPU available. Experiments show that BitMapper2 was significantly faster than the state-of-the-art all-mappers, while requiring less space.
The Perception and Production of Word-Initial Korean Stops by Native Speakers of Japanese

Previous studies have shown that non-native speakers of Korean not only have difficulty producing the word-initial three-way stop contrast, but also exhibit a wide range of production patterns. Because these studies have only investigated native (L1) speakers of English and Mandarin and given the overall paucity of research on non-native Korean, it is not yet clear how dependent these findings are on the particular native language under investigation. The current paper reinforces our empirical grounding via extension to L1 speakers of Japanese. It is shown that although naïve Japanese listeners consistently perceive Korean fortis stops as voiced, and Korean lenis and aspirated stops as voiceless, novice second language learners do not produce any significant difference among the three stop categories, despite producing clear differences between their native Japanese stop categories. Unlike in previous studies of L1 speakers of English and Mandarin, there was very little inter-speaker variation, and all speakers produced all Korean stops with long lag voice onset time.
Trends in treatments of thyroid disease following iodine fortification in Denmark: a nationwide register-based study

Background Long-term iodine exposure may influence the frequency of thyroid disease treatments through fluctuations in thyroid diseases. Yet, the long-term fluctuations in thyroid disease treatments upon iodine fortification (IF) are not fully known. We aimed to examine the development in thyroid disease treatments in Denmark before and following the implementation of IF in 2000. Methods Nationwide data on antithyroid medication, thyroid hormone therapy, thyroid surgery, and radioiodine treatment were obtained from Danish registries. Negative binominal regression was applied to analyze annual changes in treatment rates adjusted for region of residence, sex, and age. Results Incidence of antithyroid medication transiently increased but fell and reached steady state from 2010 at an incidence rate ratio (RR) of 0.72 (95% confidence interval [CI] 0.67–0.77) compared to year 2000. Thyroid hormone therapy increased and reached steady state in 2010 at an incidence RR of 1.75 (95% CI 1.62–1.89) compared to year 2000. Thyroid surgery was constant except for higher rates in 2014–2015, and radioiodine treatment fluctuated with no apparent pattern. Conclusion Ten years after IF, a steady state was observed for incident antithyroid medication below the level at IF, and thyroid hormone therapy above the level at IF. Only small changes were observed in thyroid surgery and radioiodine treatment. In the same period, changes in diagnostic and treatment practices and lifestyle factors are likely to have occurred and should be considered when evaluating the effects of IF on treatment of thyroid diseases.
Development and Validation of an Instrument Measuring Self-Care in Persons With a Fecal Ostomy

PURPOSE: The purpose of this study was to describe development of the Specific Self-Care for Ostomized Patients Questionnaire (CAESPO) instrument and evaluate its construct validity, internal reliability, and test-retest reliability (temporal stability). DESIGN: Prospective evaluation of psychometric properties of the instrument. SUBJECTS AND SETTING: The study sample comprised 125 persons (n = 89, 71.2% men) with a temporary (n = 42, 33.6%) and permanent (n = 83, 66.4%) colostomy (n = 102, 81.6%) and ileostomy (n = 23, 18.4%). Their mean age was 66.72 years; all had undergone ostomy surgery at least 3 months prior to study participation. Participants were drawn from 4 acute care facilities in the province of Castellon, Spain. INSTRUMENT: The CAESPO Questionnaire is completed by a nurse or health care provider. It comprises 3 sections: the first queries sociodemographic data, the second queries pertinent clinical data, and the third contains 58 scored items with 4 ordinal responses. Possible cumulative scores ranged from 58 to 232 points; scores are reported based on a derived percentage score that varies from 0 to 100, where a score of 0 indicates lower self-care and 100 indicates a high level of self-care. METHODS: Data were collected at baseline and retesting was completed 6 months later. Internal consistency of the CAESPO was evaluated using the Cronbach &agr; coefficient; temporal stability (test-retest reliability) was evaluated using the test-retest procedure; confirmatory factor analysis based on conceptually hypothesized factor structure was performed to evaluate construct validity. RESULTS: Initial assessment of the construct validity of the CAESPO using confirmatory factory analysis revealed a poor fit, resulting in removal of multiple items from each of the subscales owing to low-factor loading values. The final model comprised 58 scored items; it was found to have a good fit based on standard indices (&khgr;2= 43.132, P < .001; root mean square error of approximation = 0.155 [0.107-0.204]; Bentler-Bonett normed fit index = 0.957; comparative fit index = 0.967; incremental fit index = 0.968), indicating adequate construct validity. The internal consistency of the CAESPO total score was acceptable at &agr; = 0.889. Test-retest reliability (temporal stability) was deemed excellent (&agr; = 0.987). CONCLUSIONS: Psychometric tests indicate that the CAESPO is a valid and reliable instrument for measuring self-care in persons living with a fecal ostomy.
Renal Mesangial Cells Isolated from Sphingosine Kinase 2 Transgenic Mice Show Reduced Proliferation and are More Sensitive to Stress-Induced Apoptosis

Background/Aims: Sphingosine 1-phosphate (S1P) is considered as a key molecule regulating various cell functions including cell growth and death. It is produced by two sphingosine kinases (SK) denoted as SK-1 and SK-2. Whereas SK-1 has been extensively studied and has been appointed a role in promoting cell growth, the function of SK-2 is controversial, and both pro-proliferative and pro-apoptotic functions have been suggested. In this study we investigated whether renal mesangial cells isolated from transgenic mice overexpressing the human Sphk2 gene (hSK2-tg) showed an altered cell response towards growth-inducing and apoptotic stimuli. Methods: hSK2-tg mice were generated by using a Quick KnockinR strategy. Renal mesangial cells were isolated by a differential sieving method and further cultivated in vitro. Lipids were quantified by mass spectrometry. Protein expression was determined by Western blot analysis, cell proliferation was determined by 3H-thymidine incorporation, and apoptosis was determined by a DNA fragmentation ELISA. Results: We show here that kidneys and mesangial cells from hSK2-tg mice express the hSK2 as well as the endogenous mouse mSK2. hSK2 and mSK2 predominantly resided in the cytosol of quiescent transgenic cells. However, S1P accumulated strongly in the nucleus and only minimally in the cytosol of transgenic cells. Functionally, hSK2-tg cells proliferated less than control cells under normal growth conditions and were also more sensitive towards stress-induced apoptosis. On the molecular level, this was reflected by reduced ERK and Akt/PKB activation, and upon staurosporine treatment, by a sensitized mitochondrial pathway as manifested by reduced anti-apoptotic Bcl-XL expression and increased cleavage of caspase-9, downstream caspase-3 and PARP-1. Conclusion: Altogether, these data demonstrate that SK-2 exerts an antiproliferative and apoptosis-sensitizing effect in renal mesangial cells which suggests that selective inhibitors of SK-2 may promote proliferation and reduce apoptosis and this may have impact on the outcome of proliferation-associated diseases such as mesangioproliferative glomerulonephritis.