Miracle-dz/UniFAR-FTUs huggingface dataset:
Systemic Hypothermia After Neonatal Encephalopathy: Outcomes of neo.nEURO.network RCT

OBJECTIVE: Mild hypothermia after perinatal hypoxic-ischemic encephalopathy (HIE) reduces neurologic sequelae without significant adverse effects, but studies are needed to determine the most-efficacious methods. METHODS: In the neo.nEURO. network trial, term neonates with clinical and electrophysiological evidence of HIE were assigned randomly to either a control group, with a rectal temperature of 37°C (range: 36.5–37.5°C), or a hypothermia group, cooled and maintained at a rectal temperature of 33.5°C (range: 33–34°C) with a cooling blanket for 72 hours, followed by slow rewarming. All infants received morphine (0.1 mg/kg) every 4 hours or an equivalent dose of fentanyl. Neurodevelopmental outcomes were assessed at the age of 18 to 21 months. The primary outcome was death or severe disability. RESULTS: A total of 129 newborn infants were enrolled, and 111 infants were evaluated at 18 to 21 months (53 in the hypothermia group and 58 in the normothermia group). The rates of death or severe disability were 51% in the hypothermia group and 83% in the normothermia group (P = .001; odds ratio: 0.21 [95% confidence interval [CI]: 0.09–0.54]; number needed to treat: 4 [95% CI: 3–9]). Hypothermia also had a statistically significant protective effect in the group with severe HIE (n = 77; P = .005; odds ratio: 0.17 [95% CI: 0.05–0.57]). Rates of adverse events during the intervention were similar in the 2 groups except for fewer clinical seizures in the hypothermia group. CONCLUSION: Systemic hypothermia in the neo.nEURO. network trial showed a strong neuroprotective effect and was effective in the severe HIE group.
E-government adoption and user’s satisfaction: an empirical investigation

Purpose – The purpose of this paper is to examine the relationships among e-government attributes in terms of social influence, perceived effectiveness, system quality, and information quality user satisfaction and intention to use e-government services in United Arab Emirates (UAE). Design/methodology/approach – This study is based on previous research on e-government services, and has relied partially on Delone and Mclean’s (2004) updated IS success model and the new theoretical and accepted model (UTAUT). These models were used to examine the impact of some selected attributes of e-government on the adoption of e-government services in the UAE from the perspective of a citizen. A questionnaire survey was used to collect data from a total of 1,800 e-government users in the UAE and structural equation modeling was utilized to test the theoretical model. Findings – This study has identified five main findings. First, it provides evidence of the direct effects of e-government attributes on user satisfactio.
The involvement of sensory neuropeptides in toluene diisocyanate‐induced tracheal hyperreactivity in the mouse airways

1 Recently, we developed a murine model to investigate toluene diisocyanate (TDI)‐induced occupational asthma. After skin‐sensitization and intranasal challenge with TDI (1%) mice exhibited tracheal hyperreactivity 24 h after the challenge. 2 The aim of the present study was to investigate the possible role for sensory neuropeptides in the development of this tracheal hyperreactivity. 3 First, we demonstrated that direct application of TDI in vitro induced the release of tachykinins from the sensory nerves in the mouse isolated trachea. Second, capsaicin pretreatment, resulting in the depletion of sensory neuropeptides, completely abolished the TDI‐induced tracheal hyperreactivity 24 h after the challenge. Third, the selective neurokinin1 (NK1)‐receptor antagonist RP 67580 (0.2 μmol kg−1) also inhibited tracheal hyperreactivity when it was administered before the challenge. However, administration of RP 67580 during the sensitization phase did not result in a suppression of the TDI‐induced tracheal hyperreactivity 24 after the challenge. 4 When TDI‐sensitized mice were topically challenged with TDI a marked ear swelling response was observed. The cutaneous response after TDI application was not affected by capsaicin pretreatment or RP 67580 administration. 5 These results clearly show that sensory neuropeptides, particularly tachykinins, are essential for the development of TDI‐induced tracheal hyperreactivity during the effector phase. The differences between the airways and skin with respect to the sensory neuropeptides is intriguing and could suggest a local action for the tachykinins in the airways.
Amyloid &bgr;-peptide levels in laser capture microdissected cornu ammonis 1 pyramidal neurons of Alzheimer's brain

Deposition of the amyloid &bgr;-peptide (A&bgr;) is a pathophysiological event associated with Alzheimer's disease. Although much is known about the molecular composition of extracellular A&bgr; deposits, the role of the intracellular pool of A&bgr; is not fully understood. We investigated whether A&bgr; levels are increased in cornu ammonis 1 pyramidal neurons of Alzheimer's disease hippocampus, using laser capture microdissection to isolate the neurons and enzyme-linked immunosorbent assay for quantification. Our results showed increased A&bgr;42 levels and an elevated A&bgr;42/A&bgr;40 ratio in neurons from sporadic as well as from familial cases of Alzheimer's disease, whereas A&bgr;40 levels remain unchanged between the cases and controls. We speculate that intracellular accumulation of A&bgr;42 increase vulnerability of cornu ammonis 1 pyramidal neurons in Alzheimer's disease.
Development of cranial muscles in the actinopterygian fish Senegal bichir, Polypterus senegalus Cuvier, 1829

Polypterus senegalus Cuvier, 1829 is one of the most basal living actinopterygian fish and a member of the Actinopterygii. We analyzed the spatial and temporal pattern of cranial muscle development of P. senegalus using whole‐mount immunostaining and serial sectioning. We described the detailed structure of the external gill muscles which divided into dorsal and ventral parts after yolk exhaustion. The pattern of the division is similar to that of urodeles. We suggest that, the external gill muscles of P. senegalus are involved in spreading and folding of the external gill stem and the branches. The fibers of the external gill muscles appear postero‐lateral to the auditory capsule. In addition, the facial nerve passes through the external gills. Therefore, the external gill muscles are probably derived from the m. constrictor hyoideus dorsalis. In contrast to previous studies, we described the mm. interhyoideus and hyohyoideus fibers as independent components in the yolk‐sac larvae. The m. hyohyoideus fibers appear lateral to the edge of the ventral portion of the external gill muscles, which are probably derived from the m. constrictor hyoideus dorsalis. These findings suggest that the m. hyohyoidues is derived from the m. constrictor hyoideus dorsalis in P. senegalus. In other actinopterygians, the m. hyohyoideus is derived from the m. constrictor hyoideus ventralis; therefore, the homology of the m. hyohyoidues of P. senegalus and other actinopterygians remains unclear. J. Morphol. 278:450–463, 2017. © 2017 Wiley Periodicals, Inc.
On the unsteady inviscid force on cylinders and spheres in subcritical compressible flow

The unsteady inviscid force on cylinders and spheres in subcritical compressible flow is investigated. In the limit of incompressible flow, the unsteady inviscid force on a cylinder or sphere is the so-called added-mass force that is proportional to the product of the mass displaced by the body and the instantaneous acceleration. In compressible flow, the finite acoustic propagation speed means that the unsteady inviscid force arising from an instantaneously applied constant acceleration develops gradually and reaches steady values only for non-dimensional times c∞t/R≳10, where c∞ is the freestream speed of sound and R is the radius of the cylinder or sphere. In this limit, an effective added-mass coefficient may be defined. The main conclusion of our study is that the freestream Mach number has a pronounced effect on both the peak value of the unsteady force and the effective added-mass coefficient. At a freestream Mach number of 0.5, the effective added-mass coefficient is about twice as large as the incompressible value for the sphere. Coupled with an impulsive acceleration, the unsteady inviscid force in compressible flow can be more than four times larger than that predicted from incompressible theory. Furthermore, the effect of the ratio of specific heats on the unsteady force becomes more pronounced as the Mach number increases.
Residence near high voltage facilities and risk of cancer in children.

OBJECTIVE--To investigate whether residence before and after birth near 50 Hz high voltage installations increases a child's risk of cancer and whether risk correlates with the strength of the magnetic field. DESIGN--A population based case-control study. SETTING--Denmark. SUBJECTS--1707 children under the age of 15 with leukaemia, tumour of the central nervous system, or malignant lymphoma diagnosed in 1968-86 and 4788 children taken from the central population register. MAIN OUTCOME MEASURES--Proximity before and after birth to existing or former 50-400 kV electrical transmission connections and substations and associated historical electromagnetic fields calculated on the basis of current load on line, phase ordering of line, and distance from the dwelling. RESULTS--A significant association was seen between all major types of childhood cancer combined and exposure to magnetic fields from high voltage installations of > or = 0.4 microT (odds ratio 5.6). At > or = 0.25 microT no significant association was seen (odds ratio 1.5). A possible association was also seen with cases of Hodgkin's disease separately at > or = 0.1 microT. CONCLUSIONS--On the basis these results and additional descriptive data on electricity consumption and incidence of childhood cancer in Denmark since the 1940s it was concluded that the proportion of childhood cancer possibly caused by 50 Hz electromagnetic fields must be small.
Structure of the Rotor of the V-Type Na+-ATPase from Enterococcus hirae

The membrane rotor ring from the vacuolar-type (V-type) sodium ion–pumping adenosine triphosphatase (Na+-ATPase) from Enterococcus hirae consists of 10 NtpK subunits, which are homologs of the 16-kilodalton and 8-kilodalton proteolipids found in other V-ATPases and in F1Fo- or F-ATPases, respectively. Each NtpK subunit has four transmembrane α helices, with a sodium ion bound between helices 2 and 4 at a site buried deeply in the membrane that includes the essential residue glutamate-139. This site is probably connected to the membrane surface by two half-channels in subunit NtpI, against which the ring rotates. Symmetry mismatch between the rotor and catalytic domains appears to be an intrinsic feature of both V- and F-ATPases.
Learning anatomy enhances spatial ability

Spatial ability is an important factor in learning anatomy. Students with high scores on a mental rotation test (MRT) systematically score higher on anatomy examinations. This study aims to investigate if learning anatomy also oppositely improves the MRT‐score. Five hundred first year students of medicine (n = 242, intervention) and educational sciences (n = 258, control) participated in a pretest and posttest MRT, 1 month apart. During this month, the intervention group studied anatomy and the control group studied research methods for the social sciences. In the pretest, the intervention group scored 14.40 (SD: ± 3.37) and the control group 13.17 (SD: ± 3.36) on a scale of 20, which is a significant difference (t‐test, t = 4.07, df = 498, P < 0.001). Both groups show an improvement on the posttest compared to the pretest (paired samples t‐test, t = 12.21/14.71, df = 257/241, P < 0.001). The improvement in the intervention group is significantly higher (ANCOVA, F = 16.59, df = 1;497, P < 0.001). It is concluded that (1) medical students studying anatomy show greater improvement between two consecutive MRTs than educational science students; (2) medical students have a higher spatial ability than educational sciences students; and (3) if a MRT is repeated there seems to be a test effect. It is concluded that spatial ability may be trained by studying anatomy. The overarching message for anatomy teachers is that a good spatial ability is beneficial for learning anatomy and learning anatomy may be beneficial for students' spatial ability. This reciprocal advantage implies that challenging students on spatial aspects of anatomical knowledge could have a twofold effect on their learning. Anat Sci Educ 6: 257–262. © 2013 American Association of Anatomists.
Active Tolerant Testing

In this work, we give the first algorithms for tolerant testing of nontrivial classes in the active model: estimating the distance of a target function to a hypothesis class C with respect to some arbitrary distribution D, using only a small number of label queries to a polynomial-sized pool of unlabeled examples drawn from D. Specifically, we show that for the class D of unions of d intervals on the line, we can estimate the error rate of the best hypothesis in the class to an additive error epsilon from only $O(\frac{1}{\epsilon^6}\log \frac{1}{\epsilon})$ label queries to an unlabeled pool of size $O(\frac{d}{\epsilon^2}\log \frac{1}{\epsilon})$. The key point here is the number of labels needed is independent of the VC-dimension of the class. This extends the work of Balcan et al. [2012] who solved the non-tolerant testing problem for this class (distinguishing the zero-error case from the case that the best hypothesis in the class has error greater than epsilon). We also consider the related problem of estimating the performance of a given learning algorithm A in this setting. That is, given a large pool of unlabeled examples drawn from distribution D, can we, from only a few label queries, estimate how well A would perform if the entire dataset were labeled? We focus on k-Nearest Neighbor style algorithms, and also show how our results can be applied to the problem of hyperparameter tuning (selecting the best value of k for the given learning problem).
Can Transparency of Information Reduce Embezzlement? Experimental Evidence from Tanzania

Embezzlement is a major concern. By means of a sequential dictator game, we investigate theoretically and experimentally whether making information more transparent and reducing the number of intermediaries in transfer chains can reduce embezzlement. Consistent with reference-dependent preferences in terms of moral ideal, we show that the impact of transparency is conditional on the length of the transfer chain and on the position of the intermediary in the chain. Its direct effect on image encourages honesty. Its indirect effect via expectations plays in the opposite direction, motivating intermediaries to embezzle more when expecting that the following intermediary will embezzle less.
Polynomial time truth-table reductions to p-selective sets

We make an elaborate analysis of the intervals defined by the ordered list of queries to the p-selective set. It turns out that the properties we derive are strong enough to get a collapse to P for several complexity classes, assuming that they are quasi-linear truth-table reducible (or in some cases o(logn)-tt reducible) to a p-selective set. More specifically, for any class /spl Kscrspl isin/{NP, PP, C=P, /spl oplus/P) we show that if /spl Kscr/ is quasi-linear truth-table reducible to a p-selective set then /spl Kscr/=P. For other Mod/sub k/P classes (k>2) we show that if Mod/sub k/P is o(log n)-truth-table reducible to a p-selective set then Mod/sub k/P=P.<<ETX>>
Hybrid precoding and combining design for millimeter-wave multi-user MIMO based on SVD

In this paper, we focus on the millimeter-wave multi-user multiple-input-multiple-output (mmWave MU-MIMO) systems and propose a low-complexity hybrid precoding and combining design, which is applicable to both fully-connected structures and sub-connected structures. Based on the channel knowledge of each user, the analog combiner for each user is independently designed based on the singular value decomposition (SVD), while the analog precoder is obtained by the conjugate transposition to maximize the effective channel gain. Then, with the resulting effective analog channel, low-dimensional baseband precoders can be efficiently applied. The proposed scheme requires no optimization techniques or any complicated iterative algorithms, while the numerical results show that it can approach the performance of fully digital schemes and even achieve a better performance in some scenarios. It is also observed that sub-connected structures can achieve a much higher power efficiency compared to fully-connected structures and are therefore promising for the future green communication systems.
Progressive supranuclear palsy: clinical and genetic aspects

Purpose of the reviewThis review focuses on the recent additions to the literature in the clinical and genetic aspects of progressive supranuclear palsy. Recent findingsClinical features of progressive supranuclear palsy are reasonably well established and known to be quite characteristic. Recent epidemiological studies suggest that the disorder is more common than previously considered and that it is frequently misdiagnosed. New laboratory and novel imaging techniques are being tested and cerebrospinal fluid levels of tau protein have been found helpful in diagnosis. Pathological and biochemical studies in progressive supranuclear palsy brains have shown the predominance of hyperphosphorylated tau isoforms which contain the sequence encoded by exon 10 (4R) aggregated into filaments. Familial tauopathies linked to tau gene mutations showing clinical and neuropathological overlap with sporadic progressive supranuclear palsy have been described. Despite recent discoveries of the strong genetic association of sporadic progressive supranuclear palsy with tau gene polymorphisms, a specific risk allele for developing the palsy has not yet been identified yet. SummaryRecent clinical studies and clinicopathological correlations are contributing significantly to the delineation of the clinical features of progressive supranuclear palsy. These features and the appropriate use of laboratory tests allow for an earlier identification of the disease and a more accurate premortem diagnosis. However, no specific biological markers for the disorder are available yet, and consequently diagnosis in the early stages or when some of the characteristic signs and symptoms are missing, remains a major challenge. Despite the recent advances in the understanding of genetic factors involved in progressive supranuclear palsy, the cause of the disease still remains unknown. Biochemical studies in brains from progressive supranuclear palsy patients provide a potential helpful instrument to improve the characterization of this disorder.
The Thermostable Direct Hemolysin Gene (tdh) of Vibrio hollisae Is Dissimilar in Prevalence to and Phylogenetically Distant from the tdh Genes of Other Vibrios: Implications in the Horizontal Transfer of the tdh Gene

Vibrio hollisae strains isolated recently from patients in various locations were examined for the presence of the thermostable direct hemolysin gene (tdh) using nucleic acid hybridization and polymerase chain reaction assays. The results were consistent with the previous finding that all strains of V. hollisae carry the tdh gene. In contrast, the tdh gene has been detected in a minority of strains for other Vibrio species (V. parahaemolyticus, V. cholerae non‐O1, and V. mimicus). Detailed phylogenetic analysis showed that the tdh genes of the non‐V. hollisae species were very closely related to each other and that the tdh gene of V. hollisae was distantly related to the tdh genes of the non‐V. hollisae species. These results and the proposed insertion sequence‐mediated tdh transfer mechanism suggest that the tdh gene may have been maintained stably in V. hollisae and that the tdh genes of the non‐V. hollisae species may have been involved in recent horizontal transfer.
Heritability and confirmation of genetic association studies for childhood asthma in twins

Although the genetics of asthma has been extensively studied using both quantitative and molecular genetic analysis methods, both approaches lack studies specific to the childhood phenotype and including other allergic diseases. This study aimed to give specific estimates for the heritability of childhood asthma and other allergic diseases, to attempt to replicate findings from genomewide association studies (GWAS) for childhood asthma and to test the same variants against other allergic diseases.
Social, lifestyle and demographic inequalities in hypertension care

Aims: Recent nationwide in-depth analyses on inequalities in hypertension prevalence and care are scarce. This study assessed sociodemographic and lifestyle factors associated with the prevalence, awareness, treatment and control of hypertension in Finland. Methods: A representative nationwide sample (participation rate 58%) of the Finnish adult population underwent a health examination and interview in 2011. After excluding participants with missing data, 4230 people were included in the analyses. Weighted regression modelling was used to explore the associations of sociodemographic and lifestyle factors with the prevalence, awareness, treatment and control of hypertension. Results: The prevalence, awareness, treatment and control rates of hypertension (blood pressure ⩾140/90 mmHg or antihypertensive medication) in Finland were 47%, 57%, 51% and 48%, respectively. Older age, male sex, lower education, retirement, higher BMI, never-smoking and heavy alcohol use were associated with a higher prevalence of hypertension (p<0.05). In contrast, younger age, non-retirement, lower BMI, smoking and high physical activity were associated with lower awareness and treatment rates (p<0.05). In addition, male sex was associated with lower awareness rates (p<0.01). Hypertension control was better in younger participants (p<0.05). Conclusions: In addition to high prevalence and moderate treatment rates of hypertension, serious sociodemographic and lifestyle inequities in hypertension care exist in Finland. Hypertension is more prevalent in older people of lower socio-economic status with adverse lifestyles. However, hypertension is more often unrecognised and untreated among people with low risk of hypertension.