Miracle-dz/UniFAR-FTUs huggingface dataset:
Managing educational practices for qualified nursing care in cardiology.

Objective: to understand significances attributed by nurses who manage nursing care to the individual affected by cardiovascular disease to relations, interactions and associations of the educational practices in a cardiovascular reference hospital. To elaborate a theoretical explanatory model based on significances attributed in the light of the complex thinking. Method: qualitative study, which used Theory Based on Data (TBD) as methodological reference. Twenty-two professionals of nursing participated in the study. Results: the results indicate need of professional qualification to ensure the safety of patients, institutional support for the realization of educational practices, attitude of openness and availability of dialogue of the health professionals and other institutional conformations for the workers' development. Conclusion: the study presents a new space for the nurse's action that can be used to qualify and optimize the nursing practice, as it provides visibility to management and care in health institutions.
1.5°C Hotspots: Climate Hazards, Vulnerabilities, and Impacts

Differentiating the impacts of climate change between 1.5°C and 2°C requires a regional and sector-specific perspective. Whereas for some regions and sectors the difference in climate variables might be indistinguishable from natural variability, other areas especially in the tropics and subtropics will experience significant shifts. In addition to region-specific changes in climatic conditions, vulnerability and exposure also differ substantially across the world. Even small differences in climate hazards can translate into sizeable impact differences for particularly vulnerable regions or sectors. Here, we review scientific evidence of regional differences in climate hazards at 1.5°C and 2°C and provide an assessment of selected hotspots of climate change, including small islands as well as rural, urban, and coastal areas in sub-Saharan Africa and South Asia, that are particularly affected by the additional 0.5°C global mean temperature increase. We interlink these with a review of the vulnerability and exposure literature related to these hotspots to provide an integrated perspective on the differences in climate impacts between 1.5°C and 2°C.
A Polygenic Risk Score Associated with Measures of Depressive Symptoms Among Older Adults

It has been suggested that depression is a polygenic trait, arising from the influences of multiple loci with small individual effects. The aim of this study is to generate a polygenic risk score (PRS) to examine the association between genetic variation and depressive symptoms. Our analytic sample included N = 10,091 participants aged 50 and older from the Health and Retirement Study (HRS). Depressive symptoms were measured by Center for Epidemiological Studies–Depression scale (CESD) scores assessed on up to nine occasions across 18 years. We conducted a genome-wide association analysis for a discovery set (n = 7,000) and used the top 11 single-nucleotide polymorphisms, all with p < 10−5 to generate a weighted PRS for our replication sample (n = 3,091). Results showed that the PRS was significantly associated with mean CESD score in the replication sample (β = .08, p = .002). The R2 change for the inclusion of the PRS was . 003. Using a multinomial logistic regression model, we also examined the association between genetic risk and chronicity of high (4+) CESD scores. We found that a one-standard-deviation increase in PRS was associated with a 36 percent increase in the odds of having chronically high CESD scores relative to never having had high CESD scores. Our findings are consistent with depression being a polygenic trait and suggest that the cumulative influence of multiple variants increases an individual’s susceptibility for chronically experiencing high levels of depressive symptoms.
Interaction of tunneling and existing structure considering the location of foundation

Two-dimensional model tests of shallow tunnels and the corresponding numerical analyses were carried out to investigate the interaction between the tunnel excavation and the adjacent foundation. The existing building loads are applied on the ground considering pile foundation. Here, the interaction effects are investigated varying the lateral distance between the tunnel and the foundation. The model tests were conducted using a newly developed device to simulate circular tunnel excavation. Non-linear finite element analyses corresponding to the model tests are also conducted using FEMtij-2D software where the subloading tij model is used as a constitutive model of soil. Surface settlement and shear strain of the ground, and earth pressure around tunnel are investigated. It is found that tunneling influences on the existing foundation when super structure exists within a certain distance from the tunnel.
Pedometer-determined step count guidelines for classifying walking intensity in a young ostensibly healthy population.

PURPOSE (a) To establish pedometer steps/min intensity categories (i.e., light, moderate, hard, very hard) for adults under controlled conditions, and (b) use these cut-points to ascertain the number of steps expected in 30 minutes of moderate intensity activity. METHODS 25 men and 25 women, ages 18-39 years, performed 6-min exercise bouts at 3 treadmill speeds (4.8, 6.4, and 9.7 km/hr). Yamax SW-200 pedometers indicated steps, and steady-state VO2 was recorded. METs were calculated by dividing steady-state VO2 by 3.5 ml x kg(-1) x min(-1). Linear regression was used to quantify the relationships between steps/min and METs across all speeds. Ten participants (5 M, 5 F) were randomly selected from the original 50 and constituted a holdout sample for cross-validation purposes (i.e, comparing actual and predicted METs; paired t-test). RESULTS The regression equation for males was: METs = -7.065 + (0.105 x steps/min) r2 = 0.803. For females it was: METs = -8.805 + (0.110 x steps/min) r2 = 0.830. Cross-validation was confirmed. CONCLUSIONS Pedometer cut-points corresponding to minimal moderate intensity walking were 96 steps/min in men and 107 steps/min in women, or roughly 100 steps/min for both. This translates to approximately 3,000 steps in 30 min of moderate-intensity ambulatory activity for both genders.
High Levels of IgA Antibodies to Helicobacter Pylori among Omani Women during Pregnancy and after Delivery.

BACKGROUND Helicobacter pylori (H. pylori), is a common infection in pregnant women accompanied by variations in the levels of the IgM, IgA and IgG antibody isotypes. The variations of anti-H. pylori antibodies during and after pregnancy, and the extent of protection they provide to the mother and the fetus are not completely understood. OBJECTIVES To investigate the changes of the anti-H. pylori IgM, IgA and IgG levels in healthy Omani pregnant women during pregnancy and 3 months after delivery. METHODS Serum samples obtained from 70 Omani healthy pregnant women, with no history of autoimmune diseases, were tested for anti-H. pylori IgM, IgA and IgG in the first trimester of pregnancy and 3 months after delivery. In parallel and as a control group, sera obtained from a group of 70 healthy non-pregnant Omani women were tested. The levels of anti-H. pylori IgM, IgA and IgG were measured using standard Enzyme Linked Immunosorbent Assays (ELISAs). RESULTS Anti-H. pylori IgA levels were found to be significantly higher during pregnancy (p=0.046) and after delivery (p=0.02) when compared to the control group. Moreover, a significant increase in the levels of anti-H. pylori IgM, IgA and IgG was detected after delivery (p=0.002) when compared to the levels during pregnancy. CONCLUSION Pregnancy is associated with an increase in the levels of anti-H. pylori IgA antibodies. In addition, anti-H. pylori IgM, IgG and IgA antibody levels increase after delivery.
Intermedilysin Is Essential for the Invasion of Hepatoma HepG2 Cells by Streptococcus intermedius

Streptococcus intermedius causes endogenous infections leading to abscesses. This species produces intermedilysin (ILY), a human‐specific cytolysin. Because of the significant correlation between higher ILY production levels by S. intermedius and deep‐seated abscesses, we constructed ily knockout mutant UNS38 B3 and complementation strain UNS38 B3R1 in order to investigate the role of ILY in deep‐seated infections. Strain UNS38 reduced the viability of human liver cell line HepG2 at infection but not of rat liver cell line BRL3A. Isogenic mutant strain UNS38 B3 was not cytotoxic in either cell line. Quantification of S. intermedius revealed that in infected HepG2 cells UNS38 but not UNS38 B3 increased intracellularly concomitantly with increasing cell damage. This difference between UNS38 and UNS38 B3 was not observed with UNS38 B3R1. Invasion and proliferation in BRL3A cells was not observed. Masking UNS38 or UNS38 B3R1 with ILY antibody drastically decreased adherence and invasion of HepG2. Moreover, coating strain UNS38 B3 with ILY partially restored adherence to HepG2 but without subsequent bacterial growth. At 1 day post‐infection, many intact UNS38 were detected in the damaged phagosomes of HepG2 with bacterial proliferation observed in the cytoplasm of dead HepG2 after an additional 2 day incubation. These results indicate that surface‐bound ILY on S. intermedius is an important factor for invasion of human cells by this bacterium and that secretion of ILY within host cells is essential for subsequent host cell death. These data strongly implicate ILY as an important factor in the pathogenesis of abscesses in vivo by this streptococcus.
"Terminal Investment" and a Sexual Conflict in the Collared Flycatcher (Ficedula albicollis)

When the expectation of future reproduction is reduced by senescence, life-history theory predicts that reproductive effort will increase with increasing age. This idea was examined in the collared flycatcher by estimating whether reproductive costs increase with female age, comparing feeding rates and weight losses of old, "senescent" females (i.e., ≥5 yr old) and middle-aged females (2-3 yr old) with the same breeding phenology and the same brood size, and testing whether feeding rate was correlated with daily energy expenditure and with weight loss of females during the nestling period. There was a negative relationship between fledgling production and subsequent survival among old females (≥5 yr old), but not among younger age classes, which suggests that reproductive effort increases with age. Also, old females fed their nestlings more often and lost more weight during the nestling period than did middle-aged females Observed feeding rates were positively correlated with daily energy expenditure and weight loss. Since there was no evidence that individuals that survived to old ages were better at all ages, the results strongly suggest that old collared flycatcher females increase their reproductive effort at the cost of a decreased probability of surviving to the next year. However, the payoff of the increased reproductive effort of old females seemed to be small. We suggest that this is a consequence of a conflict between the sexes over the division of work, because old females generally are mated to younger males that probably have better future prospects. Data on male feeding rates in relation to female feeding rates support this idea.
Cultivation, proliferation and characterization of thymic macrophages.

Successful long-term culture of murine thymic macrophages was achieved by plating adherent thymic cells, in the presence of L cell-conditioned medium, on dishes coated with an extracellular matrix. Adherent thymic cells in normal conditions of in-vitro culture do not proliferate. Those maintained on plastic tissue-culture dishes, and exposed to L cell-conditioned medium, proliferate slowly to a limited degree and form very small colonies. In contrast, when cultured in dishes coated with an extracellular matrix formed by corneal endothelial cells, in the presence of L cell-conditioned medium, adherent thymic cells proliferate rapidly and after 12-21 days in culture form large colonies (about 3-5 mm in diameter). The proliferating cells were identified to be mononuclear phagocytes by their morphological appearance, their ability to ingest both bacteria and antibody-coated erythrocytes and by their nonspecific esterase activity. These cells were also shown to exhibit cell surface antigens that are characteristic of differentiated macrophages, e.g. Fc receptors and the specific macrophage cell surface marker F4/80. A high percentage of these cultured cells were found to bear I-A antigens. The adherent thymic mononuclear phagocytes could be trypsinized and passaged while maintaining both their ability to proliferate and their specific macrophage characteristics for a period of 70 days. Thus, monocyte-macrophage stem cells ae present in the thymus, and under appropriate in-vitro conditions, can be made to proliferate and mature to I-A-bearing macrophages.
Intracranial Dural Arteriovenous Fistulas: Analysis of 60 Patients

Objective: To analyze and update the clinical symptomatology, CT and MRI findings, angiographic features, and therapeutic outcomes of patients with dural arteriovenous fistulas (DAVFs). Background: Studies of DAVFs in a large number of patients have seldom appeared in neurology literature. Methods: The authors investigated 60 consecutive patients with DAVFs who were admitted between January 1991 and January 2001. The DAVFs were graded into five types according to the classification of Cognard et al. [Radiology 1995;194:671–680]. Presumable etiologies, clinical features, imaging findings and therapeutic outcomes were evaluated on the basis of the location and type of DAVFs. Results: Sinus thrombosis, previous trauma, craniotomy, cerebral infarction and acupuncture were detected as possible etiologic factors of DAVFs. The cavernous sinus (57%) was the most common location of DAVFs. Although the neurological symptoms were closely related to the location of the DAVFs, in some patients, there were also symptoms that did not reflect the location. Although the women outnumbered the men, the men presented with aggressive neurological manifestations more often (p < 0.05). Ten out of 12 patients (83%) with DAVFs involving locations other than the large sinuses presented with aggressive neurological manifestations. 70% of brain CTs and 81% of brain MRIs showed abnormal findings suggestive of DAVFs. Of 33 patients who underwent only endovascular embolization, 29 patients (88%) were cured or improved. Radiosurgery and surgical excision done in some patients provided fair results. Patients with DAVFs involving large sinuses showed a better therapeutic outcome than those in whom locations other than the large sinuses were involved, while patients without venous ectasia had more a favorable outcome than those with it (each, p < 0.01). Conclusions: DAVFs result from various etiologic factors, show diverse manifestations usually reflecting the location and can be treated successfully in most patients. Factors related to poor clinical outcome include male sex, the presence of venous ectasia and involved locations other than the large sinuses.
Evolution of dexamethasone-induced insulin resistance in rats.

Glucocorticoids are known to cause insulin resistance and glucose intolerance. Although there have been many studies investigating the mechanism of this effect, several aspects remain to be clarified. The aim of this study was to investigate the evolution and sites of insulin resistance in dexamethasone-treated rats. To achieve this, chronically catheterized nonstressed rats had glucose kinetics measured during an oral glucose tolerance test by means of a double isotope technique. Studies were performed after 6, 48, or 96 h of dexamethasone administration (10 micrograms.rat-1.day-1) and were compared with control rats not treated with the steroid. Total hepatic glucose production (HGP) was increased in the 6-h (166 +/- 8.3, P less than 0.05) and 48-h (198 +/- 21, P less than 0.03) treated groups but not in the 96-h treated rats (140 +/- 8, P = 0.99) compared with the controls (141 +/- 8 mg/55 min). This increased HGP was despite the presence of higher insulin levels in the steroid-treated rats (1,220 +/- 115, P less than 0.09; 1,732 +/- 197, P less than 0.005; 1,567 +/- 107, P less than 0.001 in 6-, 48-, and 96-h treated rats, respectively, compared with 937 +/- 99 mU.l-1 x 55 min-1 in control rats). The metabolic clearance rate of glucose was higher in the dexamethasone-treated rats (200 +/- 14, P less than 0.07; 227 +/- 18, P less than 0.01; 227 +/- 17, P less than 0.01 in 6-, 48-, and 96-h groups, respectively, compared with 165 +/- 10 ml/55 min in control rats). (ABSTRACT TRUNCATED AT 250 WORDS)
Territorial Politics and Institutional Change: A Comparative-Historical Analysis

In the introductory article for this special issue, we argue that studying territorial politics through comparative-historical analysis (CHA) offers valuable insights in understanding the changing territorial distribution of authority in federal, regional, and decentralized countries. We point to limitations that have beset the analysis of territorial politics and suggest how recent advances in CHA offer a promising approach to avoid and overcome existing shortcomings. We also demonstrate and illustrate the ways that vertical and horizontal dimensions of territorial structures evolve over time, from the moment they are created to subsequent episodes of reform. Our aim is to show that time has causal relevance in connecting past and present patterns of change and continuity, and thus in capturing the formative and developmental pathways of changes in territorial authority.
Moral Values and Voting

This paper studies the supply of and demand for moral values in recent US presidential elections. Using a combination of large-scale survey data and text analyses, I find support for the hypothesis that both voters and politicians exhibit heterogeneity in their emphasis on universalist relative to communal moral values and that politicians’ vote shares partly reflect the extent to which their moral appeal matches the values of the electorate. Over the last decade, Americans’ values have become increasingly communal—especially in rural areas—which generated increased moral polarization and is associated with changes in voting patterns across space.
Human Capital, Organizational Orientations and Performance: Evidence From the Restaurant Industry

ABSTRACT The study examines how human capital combines with and influences organizational orientations to determine performance. Specifically, this study investigates small restaurant businesses’ ability to effectively exploit intangible resources and capabilities, rather than tangible resources, in order to produce sustainable competitive advantage. A structured questionnaire was used to survey owners/managers of small independent restaurants in the United States. The results demonstrate that human capital, market orientation and entrepreneurial orientation serve as intangible resources and capabilities that can augment the competitive position of independent restaurants, and thereby improve performance. Human capital also combines with and influences the adoption of market orientation and subsequent performance.
Acoustically active lipospheres containing paclitaxel: a new therapeutic ultrasound contrast agent.

RATIONALE AND OBJECTIVES Paclitaxel-carrying lipospheres (MRX-552) were developed and evaluated as a new ultrasound contrast agent for chemotherapeutic drug delivery. METHODS Paclitaxel was suspended in soybean oil and added to an aqueous suspension of phospholipids in vials. The headspace of the vials was replaced with perfluorobutane gas; the vials were sealed, and they were agitated at 4200 rpm on a shaking device. The resulting lipospheres containing paclitaxel were studied for concentration, size, acute toxicity in mice, and acoustic activity and drug release with ultrasound. Lipospheres containing sudan black dye were produced to demonstrate the acoustically active liposphere (AAL)-ultrasound release concept. RESULTS Acoustically active lipospheres containing paclitaxel had a mean particle count of approximately 1 x 10(9) particles per mL and a mean size of 2.9 microns. Acute toxicity studies in mice showed a 10-fold reduction in toxicity for paclitaxel in AALs compared with free paclitaxel. The AALs reflected ultrasound as a contrast agent. Increasing amounts of ultrasound energy selectively ruptured the AALs and released the paclitaxel. CONCLUSIONS Acoustically active lipospheres represent a new class of acoustically active drug delivery vehicles. Future studies will assess efficacy of AALs for ultrasound-mediated drug delivery.
Prudential Supervisors’ Independence and Income Smoothing in European Banks

We investigate the role of prudential supervisors’ independence in affecting income smoothing behavior in European banks. Powerful national supervisors are predicted to influence the accounting practices of their supervised entities, shaping the properties of the accounting numbers they prepare. In particular, we study whether greater independence of powerful supervisors from the government and from the industry is associated with lower income smoothing. We use the mandatory adoption of a single set of accounting standards in Europe as a shock to the influence of prudential supervisors over national banks’ accounting practice. Our results confirm that political and industry independence of the supervisor are important determinants of income smoothing. This suggests that independence of prudential supervisors is a desirable governance characteristic, with positive impacts on financial transparency.
Linking Environmental Management to Environmental Performance: The Interactive Role of Industry Context

In the past, corporate sustainability scholars advocated that, for many firms, environmental management could turn into a valuable capability conferring a competitive advantage. However, little attention has been paid to the role of the industry context and its influence on the relationship between environmental management and organizational performance. In this study, we examine the effect on this relationship of three contextual variables: munificence, dynamism and complexity. Drawing on longitudinal data from 336 firms representing 30 industries, we find that munificence enhances the degree to which a firm can leverage its environmental management capabilities to improve environmental performance. Copyright © 2017 John Wiley & Sons, Ltd and ERP Environment