Miracle-dz/UniFAR-FTUs huggingface dataset:
Altered RECQL5 expression in urothelial bladder carcinoma increases cellular proliferation and makes RECQL5 helicase activity a novel target for chemotherapy

RECQ helicases are a family of enzymes with both over lapping and unique functions. Functional autosomal recessive loss of three members of the family BLM, WRN and RECQL4, results in hereditary human syndromes characterized by cancer predisposition and premature aging, but despite the finding that RECQL5 deficient mice are cancer prone, no such link has been made to human RECQL5. Here we demonstrate that human urothelial carcinoma of the bladder (UCC) has increased expression of RECQL5 compared to normal bladder tissue and that increasing RECQL5 expression can drive proliferation of normal bladder cells and is associated with poor prognosis. Further, by expressing a helicase dead RECQL5 and by depleting bladder cancer cells of RECQL5 we show that inhibition of RECQL5 activity has potential as a new target for treatment of UCC.
How do corporate reputation and customer satisfaction impact customer defection? A study of private energy customers in Germany

Purpose – To analyze whether perceived corporate reputation and customer satisfaction are directly associated with customer intention.Design/methodology/approach – Using structural equation modeling, the study is based on the responses to a written questionnaire of 462 customers of a large German utility.Findings – A non‐significant and weak relationship was found between corporate reputation and switching intention. The postulated impact of customer satisfaction on customer switching intention was confirmed. Corporate reputation and customer satisfaction were found to be strongly correlated.Research limitations/implications – The sample includes only one company's customers, so the findings may not be generalized to other industries. Future research in other service industries is called for.Practical implications – The threat of customer defection in deregulated markets requires power supply companies to examine the marketing instruments and measures required to inhibit customer willingness to switch pow.
Effective tax levels using the Devereux Griffith methodology: Project for the EU Commission TAXUD/2008/CC/099. Report 2009

This report on behalf of the EU Commission presents estimates of the effective tax rates on investment in the EU member states over the period 1998 to 2009. Furthermore, the EU candidate countries Croatia, FYROM, Turkey as well as Norway, Switzerland, Canada, Japan and the United States are covered over the period 2005 to 2009. The report extents the work completed in project TAXUD/2005/DE/310. The former report covered the period 1998 to 2007. In addition to the update of previous results, report comprehensively includes the analysis of personal taxes on investment and saving at the shareholder level when calculating effective tax rates on domestic investment. The report considers primarily taxes on corporations in each country, but also includes analysis of personal taxes on investment and saving. It also considers both cross-border investment and investment by small and medium sized enterprises (SME).
Approaches to relationship development processes in inter‐firm networks

This paper examines the dynamics of business networks, that is, how these inter‐organisational networks grow and decline. Three rival theories are investigated: predetermined sequence of stages, evolution of unpredictable states and joinings theory which focus on positioning, repositioning and exit. A case study methodology was used for data collection and analysis. Data were collected from in‐depth interviews with network managers/owners of firms networking with other overseas firms entering into Australian and Asian markets. The findings revealed that inter‐firm network development is an evolution of unpredictable states rather than a predetermined sequence of irreversible stages. In turn, a six “states” model of inter‐firm network development was formulated from data. Implications for managerial practices and further research are advanced.
Approaches to accelerating product and process development

How can organizations shorten the length of the new products development process? This is undoubtedly one of the key questions facing managers today. One important goal is early market entry, maximizing competitive advantage in the process. Bela Gold draws on his experience with product and process development in a wide array of industries to identify eight approaches to accelerating development. Drawing on his field research, he briefly appraises the potentials, limitations, and risks of each and then discusses implications for a more promising strategy.
Effect of intravenous infusion of dexmedetomidine on perioperative haemodynamic changes and postoperative recovery: A study with entropy analysis

Background: Dexmedetomidine, an α2 agonist, when used as an adjuvant in general anaesthesia attenuates stress response to various noxious stimuli, maintains perioperative haemodynamic stability and provides sedation without significant respiratory depression postoperatively. Methods: Sixty patients were randomly divided into two groups of 30 each. In group A, fentanyl 2 μg/kg and in group B dexmedetomidine were given intravenously as loading dose of 1 μg/kg over 10 min prior to induction. After induction with thiopentone, in group B, dexmedetomidine was given as infusion at a dose of 0.2–0.8 μg/kg. Sevoflurane was used as inhalation agent in both groups. Haemodynamic variables and entropy (response entropy and state entropy) were recorded continuously. Postoperative sedation and recovery were assessed by sedation score and modified Aldrete's score, respectively. Results: Dexmedetomidine significantly attenuates stress response at intubation with lesser increase in heart rate (10% vs. 17%), systolic blood pressure (6% vs. 23%) and diastolic blood pressure (7% vs. 20%) as compared to the control group (P<0.05). Intraoperatively, an average of 8% fall in systolic blood pressure and 8.16% fall in diastolic pressure in the test group as compared to 3.6% rise in systolic and 3.3% in diastolic pressure of the control group was observed. Postoperatively, the test group showed significant sedation at 2 h as compared to the control group (P=0.00) and recovery was better in the control group for the first 2 h post extubation. Conclusion: Dexmedetomidine attenuates various stress responses during surgery and maintains the haemodynamic stability when used as an adjuvant in general anaesthesia. Also, the sedative action of dexmedetomidine delays recovery for the first few hours post extubation.
Financial Literacy Strategies: Where Do We Go from Here?

The evolution of market economies has dramatically broadened the opportunities of consumers, workers, investors, and firms. Financial services have become especially free and accessible, but also increasingly complex. For the new financial freedom to help most people, they must understand their choices and the likely implications of alternative decisions. Unfortunately, many Americans have a weak grasp of basic personal finance principles. This paper emphasizes the importance of financial literacy in an increasingly complex market economy and examines the current state of financial education in the U.S. and abroad. We explore two methods of delivering financial knowledge—through broad financial curriculums and through more focused 'teachable moments. ' After examining the pros and cons of each, along with the evidence about their effectiveness, we suggest that a combination of the two perspectives, with the specific topics and behavioral strategies varying by target audience. We conclude by calling for a more rigorous evaluation of the effects of existing programs.
IMO and different fit types as key enablers of employee brand-supporting behaviour

This study integrates the fit theory, the equity theory and the balance theory in order to investigate the role of internal market orientation (IMO) as a philosophy that can enhance front-line employee brand-supporting behaviour both directly and indirectly through increasing their fit with their different aspects of their environment. Furthermore, it is examined whether IMO adoption facilitates several fit types, namely employee–organization fit, employee–supervisor fit, employee–job fit and employee–group fit as well as assessed the joint impact of these different types of fit on front-line employee brand-supporting behaviour.
Contact-Free Support Structures for Part Overhangs in Powder-Bed Metal Additive Manufacturing

This study investigates the feasibility of a novel concept, contact-free support structures, for part overhangs in powder-bed metal additive manufacturing. The intent is to develop alternative support designs that require no or little post-processing, and yet, maintain effectiveness in minimizing overhang distortions. The idea is to build, simultaneously during part fabrications, a heat sink (called “heat support”), underneath an overhang to alter adverse thermal behaviors. Thermomechanical modeling and simulations using finite element analysis were applied to numerically research the heat support effect on overhang distortions. Experimentally, a powder-bed electron beam additive manufacturing system was utilized to fabricate heat support designs and examine their functions. The results prove the concept and demonstrate the effectiveness of contact-free heat supports. Moreover, the method was tested with different heat support parameters and applied to various overhang geometries. It is concluded that the heat support proposed has the potential to be implemented in industrial applications.
LEARNING AND DISCRIMINATION IN THE OCTOPUS

Visual responses and the mechanism of visual discrimination . ( I ) Visual responses by untrained animals . (2) Effects of feeding on tendency to attack . (3) Representations in the memory that promote attack . (4) Habituation and extinction of responses . (5) Representations that prevent attack . (6) Visual discrimination . (7) The dimensions used for shape discrimination . (8) Visual discrimination after statocyst removal . (9) Anatomicalsigns ofvertical and horizontal organization in the visual system Chemo-tactile learning. (I) Anatomy of the chemotactile learning system . (2) Chemo-tactile responses after section of optic nerves and removal of optic lobes . (3) Learning to accept edible and reject inedible objects . (4) Chemical and tactile discrimination . (5) Effects of removal of the inferior frontal and subfrontal lobes. 32
E‐retailing by banks: e‐service quality and its importance to customer satisfaction

Purpose – The purpose of this paper is to explore the measurement of e‐service quality for e‐retail banking, the importance of e‐service quality dimensions to e‐retail bank customers, and the relationship between e‐service quality and customer satisfaction.Design/methodology/approach – Results are drawn from a self‐completed survey of a convenience sample of 200 Australian respondents who regularly use online banking facilities. Factor analysis and regression analysis are used to ascertain factor structure and determine the impact of e‐service quality dimensions on satisfaction.Findings – A four‐factor solution (E‐ServQual) represented by “personal needs”, “site organisation”, “user‐friendliness” and “efficiency” is found, with all factors rated as important. E‐ServQual is found to be a predictor of overall customer satisfaction with banking performance, but “efficiency” is not found to be predictive. Overall satisfaction is lower than overall e‐service quality.Research limitations/implications – The Aust.
The Historical Role of the European Shadow Banking System in the Development and Evolution of Our Monetary Institutions

When we hear about the 2008 Lehman Brothers crisis, immediately we relate it to the concept of "shadow banking system"; however, the credit intermediation involving lightly regulated entities and activities outside the traditional banking system are not new for the European Financial Systems, after all, many innovations developed in the past, were adopted by European nations and exported to the rest of the world (i.e. coinage and central banking), and European innovators unleashed several financial crises related to "shadowy" financial intermediaries (i.e. the Gebroeders de Neufville crisis of 1763). However, despite not many academics, legislators and regulators even agree on what "shadow banking" is, this latter does not refer exclusively to the functions of credit intermediation and maturity transformation. This concept also refers to the creation of assets such as digital media of exchange which are designed under the influence of Friedrich Hayek and the Austrian School of Economics. This lack of a uniform definition of "shadow banking" has limited our regulatory efforts on key issues like the private money creation, a source of vulnerability in the financial system that, paradoxically, at the same time could result in an opportunity to renovate European institutions, heirs of the tradition of the Wisselbank and the Bank of England which, during the seventeenth century, faced monetary innovations and led the European monetary revolution that originated the current monetary and regulatory practices implemented around the world.
The role of corporate culture in relationship marketing

Purpose – The role of corporate culture in relationship marketing is significantly under‐researched, although there is evident consensus in the literature about the importance of this topic. The purpose of this paper is to present a model for the corporate culture of a relationship‐marketing‐oriented company.Design/methodology/approach – A qualitative methodology involving 58 in‐depth interviews that were analysed and interpreted from a grounded theory standpoint was adopted in order to build a conceptual model.Findings – The two key shared values required to successfully put relationship marketing into effect are client orientation and a high degree of concern for employees. Furthermore, another six shared values (trust, commitment, teamwork, innovation, flexibility, and results orientation) also seem to facilitate the development of a relationship marketing orientation.Research limitations/implications – Although the research methodology is qualitative and does not allow statistical generalisation, the .
Assessing women's apparel shopping behaviour on the internet

This investigation evaluates women’s attitude as an overall inclination towards apparel shopping online via email questionnaire. Its findings suggest that women generally show positive attitudes towards shopping online for apparel. Women who shop for apparel online are aware of some of the discouraging features of online shopping, but these features do not deter them from buying online. The implication for online retailers is that they should focus on making the experience of online shopping more accommodating and more user-friendly. This is important because the positive features of online shopping (‘convenience’, ‘usefulness’, ’ease of use’, and ‘efficiency’) appear to be more important than the negative features (‘lack of security’, ‘privacy of information’ and ‘online fraud’).
Berberine Decreased Inducible Nitric Oxide Synthase mRNA Stability through Negative Regulation of Human Antigen R in Lipopolysaccharide-Induced Macrophages

Berberine, a major isoquinoline alkaloid found in medicinal herbs, has been reported to possess anti-inflammatory effects; however, the underlying mechanisms responsible for its actions are poorly understood. In the present study, we investigated the inhibitory effects of berberine and the molecular mechanisms involved in lipopolysaccharide (LPS)-treated RAW 264.7 and THP-1 macrophages and its effects in LPS-induced septic shock in mice. In both macrophage cell types, berberine inhibited the LPS-induced nitric oxide (NO) production and inducible NO synthase (iNOS) protein expression, but it had no effect on iNOS mRNA transcription. Suppression of LPS-induced iNOS protein expression by berberine occurred via a human antigen R (HuR)-mediated reduction of iNOS mRNA stability. Molecular data revealed that the suppression on the LPS-induced HuR binding to iNOS mRNA by berberine was accompanied by a reduction in nucleocytoplasmic HuR shuttling. Pretreatment with berberine reduced LPS-induced iNOS protein expression and the cytoplasmic translocation of HuR in liver tissues and increased the survival rate of mice with LPS-induced endotoxemia. These results show that the suppression of iNOS protein expression by berberine under LPS-induced inflammatory conditions is associated with a reduction in iNOS mRNA stability resulting from inhibition of the cytoplasmic translocation of HuR.
Reliability of accelerometry-based activity monitors: a generalizability study.

INTRODUCTION Numerous studies have examined the validity of accelerometry-based activity monitors but few studies have systematically studied the reliability of different accelerometer units for assessing a standardized bout of physical activity. Improving understanding of error in these devices is an important research objective because they are increasingly being used in large surveillance studies and intervention trials that require the use of multiple units over time. METHODS Four samples of college-aged participants were recruited to collect reliability data on four different accelerometer types (CSA/MTI, Biotrainer Pro, Tritrac-R3D, and Actical). The participants completed three trials of treadmill walking (3 mph) while wearing multiple units of a specific monitor type. For each trial, the participant completed a series of 5-min bouts of walking (one for each monitoring unit) with 1-min of standing rest between each bout. Generalizability (G) theory was used to quantify variance components associated with individual monitor units, trials, and subjects as well as interactions between these terms. RESULTS The overall G coefficients range from 0.43 to 0.64 for the four monitor types. Corresponding intraclass correlation coefficients (ICC) ranged from 0.62 to 0.80. The CSA/MTI was found to have the least variability across monitor units and trials and the highest overall reliability. The Actical was found to have the poorest reliability. CONCLUSION The CSA/MTI appeared to have acceptable reliability for most research applications (G values above 0.60 and ICC values above 0.80), but values with the other devices indicate some possible concerns with reliability. Additional work is needed to better understand factors contributing to variability in accelerometry data and to determine appropriate calibration protocols to improve reliability of these measures for different research applications.
Delivering Deposit Services: ATMs versus Branches

Automated teller machines (ATMs) have expanded in number from 2,000 to 90,000 over the last 20 years, substantially increasing consumer convenience in the delivery of deposit services. The cost reductions expected to flow to banks from the substitution of ATMs for banking offices have not been realized, but bank profits appear to have risen slightly from this technological change.
Enzymatic pathway for the formation of cotinine, a major metabolite of nicotine in rabbit liver.

A main reaction of nicotine metabolism in rabbit appears to be hydroxylation in the alpha position of the pyrrolidine ring to form a hydroxynicotine. This oxidation occurs in liver microsomes and requires TPNH and O2; the product has the properties of a cyclized amino aldehyde. The hydroxynicotine then undergoes oxidation to cotinine, a reaction that may be catalyzed by an aldehyde oxidase.
Human herpesvirus 6 antigenaemia in allogeneic stem cell transplant recipients: impact on clinical course and association with other beta‐herpesviruses

Human herpesvirus 6 (HHV‐6) antigenaemia was prospectively studied in 58 adult allogeneic stem cell transplant (SCT) recipients. Altogether 42 of 58 recipients (72%) demonstrated HHV‐6 specific antigens in peripheral blood mononuclear cells after SCT, 22 of 36 (61%) when the donor was a sibling and 20 of 22 (91%) when the donor was unrelated. The cumulative incidence of HHV‐6A, HHV‐6B, HHV‐7, and cytomegalovirus antigenaemia during the first 6 months after SCT was 33%, 62%, 44% and 63% respectively. The median day of the onset of each antigenaemia was +24, +4, +59, and +46 after SCT respectively. There were no clinical findings related to HHV‐6A and HHV‐7 antigenaemias. A rash was diagnosed in 10 of 38 (26%) HHV‐6B antigenaemia positive patients during the first month after SCT compared with one of 20 (5%) HHV‐6B negative patients. Of the HHV‐6B antigenaemia cases, six of 10 rashes were treated as acute graft‐versus‐host disease (GVHD) and four of 10 were considered to be of a viral origin. Fifteen patients had acute GVHD diagnosed. Acute GVHD manifested statistically significantly (P = 0·034) earlier in the nine patients with HHV‐6B antigenaemia compared with the six patients who were HHV‐6B negative.
Prevalence and factors associated with childhood visual impairment in Ethiopia

Background Visual impairment is a significant loss of vision. It has an impact on the prosperity of different countries. It has been difficult to plan preventive measures against visual impairment due to the scarcity of data about the extent of the problem. Objectives The study was aimed at assessing the prevalence and identifying factors associated with visual impairment among school-age children in Ethiopia. Materials and methods A cross-sectional study design was used in four randomly selected schools found in Addis Ababa from May 15 to June 14, 2016. A total of 804 school-age students were selected using the simple random sampling method. Bivariable logistic regression and multivariable logistic regression were conducted. A p-value <0.05 was taken as a significant association. Results A total of 718 students participated in the study, obtaining a response rate of 89.3%. In all, 7.24% of school-age children were visually impaired, of whom 3.9% had low vision and 3.34% had severe visual impairment. Factors associated with visual impairment were being female (adjusted odds ratio [AOR], 2.28; 95% confidence interval [CI], 1.06–3.50), being in the age group of 10–13 years (AOR, 2.94; 95% CI, 1.36–6.22), being in the age group of 14–18 years (AOR, 4.06; 95% CI, 2.17–11.95), being a private school student (AOR, 2.61; 95% CI, 1.81–4.41), watching television for 2–4 hours/day (AOR, 3.56; 95% CI, 1.37–7.34), watching television at <1 m (AOR, 7.65; 95% CI, 2.59–34.61), watching television at 1–2 m (AOR, 6.89; 95% CI, 1.74–25.27), mobile exposure for 2–4 hours/day (AOR, 2.61; 95% CI, 1.35–4.58), mobile exposure for >4 hours/day (AOR, 3.05; 95% CI, 1.41–9.18), medical visit while experiencing symptoms (AOR, 11.32; 95% CI, 1.80–82.25) and no medical visit experience (AOR, 3.84; 95% CI, 0.46–31.76). Conclusion The majority of the visually impaired school-age children had low vision. Sex, age, school type, television exposure duration, the distance of television exposure, mobile exposure and medical visit were factors associated with visual impairment. Increasing community awareness about early detection of visual impairment and providing affordable eye health service may decrease the prevalence of visual impairment.
Exploring the Effect of Transformational Leadership on Nonprofit Leader Engagement

Researchers have shown that transformational leadership is a valid leadership theory through research of for-profit organizations; however, there is a lack of empirical support among nonprofit organizations (Riggio, Bass, & Orr, 2004). The intent of this study is to determine whether nonprofit employees are more highly engaged in organizations in which transformational leadership is practiced. Propositions regarding relationships are addressed, including implications and suggestions for future research.