Miracle-dz/UniFAR-FTUs huggingface dataset:
A Study of Uses of ICT in Primary Education through Four Winning School Cases in the Taiwan Schools Cyberfair

The purpose of this study was to understand, describe and interpret the uses of information communication technology (ICT) in primary education in the Taiwan Schools Cyberfair as a means to expand and enhance student learning in an extra-curricular setting. Four winning schools, with 48 teachers and students involved, were purposefully selected for study. The research findings revealed that students in each group were highly motivated through the extensive use of ICT. Through long-term engagement with ICT, students were empowered to conduct both wider and deeper exploration of their selected topics of interest. We report and describe the effects of using ICT. In this study, three collaborative learning models for applying ICT in project- based learning (PBL) mode are identified in the specific contexts: the SCGP model (same class, grade, and project); the DCGSP model (different class and grade, same project) and the DCGP model (different class, grade, and project). In addition, we identify a new and important collaborative model, SPECS, which stands for school (intra), parents, enterprises, community, and school (inter). The SPECS model connects all the possible participants involved in the ICT-enabled activities that contributed to the success of the outstanding performances of the four winning schools at the Schools Cyberfair contest. In the conclusion we discuss some specific issues relating to PBL.
Liquidity, Limit-to-Arbitrage, and Premium for Financial Distress

Stocks under …nancial distress, measured by the Default Likelihood Indicator (DLI, Vassalou and Xing 2004) earn large returns during the …rst month after portfolio formation, a phenomenon di¢ cult to explain using standard asset pricing models. We argue that when stocks experience …nancial distress, they become less liquid at the same time. This lack of liquidity leads to temporary price concession. The subsequent price recovery explains the …rst-month high returns on …nancially distressed stocks. These large returns can therefore be interpreted as compensation for liquidity provision. The lack of liquidity for …nancially distressed stocks is closely related to capital immobility and limit-to-arbitrage.
Anxiety and depression among college students with attention-deficit/hyperactivity disorder (ADHD): Cross-informant, sex, and subtype differences

ABSTRACT Objective: This study examined symptoms of anxiety and depression among college students with attention-deficit/hyperactivity disorder (ADHD). Participants: Data were collected between March 2011 and March 2016 from 150 college students with ADHD and 150 college students without ADHD. Method: Participants with ADHD were compared to a sex- and ethnicity-matched control group. For the ADHD group, parent and self-report of anxiety and depression were also compared. Results: College students with ADHD self-reported significantly higher anxiety and depressive symptoms than did students without ADHD. Scores on parent-report measures of anxiety and depressive symptoms were significantly higher than scores on self-report measures. Significant sex differences were found for participants with ADHD, with females showing higher depressive and anxiety symptoms than males. Parent-reported anxiety symptoms were higher for those with inattentive type ADHD compared to combined type ADHD. Conclusion: The current study highlights the importance of multi-informant assessment in ADHD evaluations for college-aged adults.
Ultraviolet Irradiation Suppresses T Cell Activation via Blocking TCR-Mediated ERK and NF-κB Signaling Pathways

UV irradiation is carcinogenic and immunosuppressive. Previous studies indicate that UV-mediated alteration of APCs and induction of suppressor T cells play a critical role in UV-induced immune suppression. In this study, we show that UV irradiation can directly (independently of APCs and suppressor T cells) inhibit T cell activation by blocking TCR-mediated phosphorylation of ERK and IκB via overactivation of the p38 and JNK pathways. These events lead to the down-modulation of c-Jun, c-Fos, Egr-1, and NF-κB transcription factors and thereby inhibit production of cytokines, e.g., IL-2, IL-4, IFN-γ, and TNF-α, upon TCR stimulation. We also show that UV irradiation can suppress preactivated T cells, indicating that UV irradiation does not only impair T cell function in response to T cell activation, but can also have systemic effects that influence ongoing immune responses. Thus, our data provide an additional mechanism by which UV irradiation directly suppresses immune responses.
Long-Term Evolution and Changing Associations of Left Ventricular Hypertrophy after Starting Hemodialysis

Background/Aims:Left ventricular hypertrophy (LVH) is prevalent in dialysis patients and is recognized as a potent risk factor for cardiovascular diseases. We examined the evolution of LVH after starting dialysis and the determinants of changes in LV mass. Methods: A cohort of 107 patients who had two or more echocardiograms at yearly intervals after starting hemodialysis was studied. Results: At baseline, the mean LV mass index (LVMI) was 145.8 g/m2 and 73 (68%) patients had LVH. During the mean follow-up period of 34.5 months, LVMI decreased by 3.9 g/m2. At last follow-up, the mean LVMI was 141.5 g/m2 and 68 (64%) patients had LVH. For changes in LVMI, a significant correlation was found in changes in systolic blood pressure, LVMI at baseline, changes in serum albumin concentration, and age. The relationship between changes in LVMI and systolic blood pressure was close during the 1st and 2nd intervals, but became weak gradually during the 3rd and 4th intervals. Conclusion: Many patients had LVH at starting hemodialysis and continued to have LVH thereafter. The most important determinants of LV mass changes were baseline LV mass and systolic blood pressure control, but the grade of reduction decreased gradually with time. These results suggest that active antihypertensive treatment should be started early to regress LVH and prevent cardiovascular diseases.
The search for clarity in communicating research results to study participants

Current guidelines on investigators' responsibilities to communicate research results to study participants may differ on (1) whether investigators should proactively re-contact participants, (2) the type of results to be offered, (3) the need for clinical relevance before disclosure, and (4) the stage of research at which results should be offered. Lack of consistency on these issues, however, does not undermine investigators' obligation to offer to disclose research results: an obligation rooted firmly in the principle of respect for research participants.
[Arterial stiffness in hypopituitary patients with life-long growth hormone deficiency].

INTRODUCTION Patients with hypopituitarism have a shorter survival period from and premature mortality due to cardiovascular complications. OBJECTIVES The aim of our study was to evaluate the arterial stiffness and hemodynamic parameters based on pulse wave analysis in 22 adult patients with long-life growth hormone (GH) and insulin-like factor I (IGF-I) deficiencies, lasting from 22 to 57 years. PATIENTS AND METHODS In all patients, a combined pituitary hormone deficiency was diagnosed. All patients were on substitution therapy, receiving levothyroxine, sex hormones and hydrocortisone (when required), but none of the patients had ever received recombinant GH therapy. A control group consisted of 36 healthy subjects strictly matched to patients by age and body mass index. In the patients and control subjects pulse wave analysis was performed with the use of Sphigmocor MX reconstructing the aortic pulse wave in a real time. RESULTS The peripheral and central augmentation indexes were significantly increased in the hypopituitary patients compared with the control subjects. The central pulse pressure was also elevated in the patients. These hemodynamic parameters pointed to an increased arterial stiffness. CONCLUSIONS In patients with hypopituitarism, the life-long GH and IGF-I deficiencies lead to an increase in the arterial stiffness.
Whole Genome Sequencing of Danish Staphylococcus argenteus Reveals a Genetically Diverse Collection with Clear Separation from Staphylococcus aureus

Staphylococcus argenteus (S. argenteus) is a newly identified Staphylococcus species that has been misidentified as Staphylococcus aureus (S. aureus) and is clinically relevant. We identified 25 S. argenteus genomes in our collection of whole genome sequenced S. aureus. These genomes were compared to publicly available genomes and a phylogeny revealed seven clusters corresponding to seven clonal complexes. The genome of S. argenteus was found to be different from the genome of S. aureus and a core genome analysis showed that ~33% of the total gene pool was shared between the two species, at 90% homology level. An assessment of mobile elements shows flow of SCCmec cassettes, plasmids, phages, and pathogenicity islands, between S. argenteus and S. aureus. This dataset emphasizes that S. argenteus and S. aureus are two separate species that share genetic material.
Intact Perception of Biological Motion in the Face of Profound Spatial Deficits: Williams Syndrome

Williams syndrome (WS) is a rare genetic disorder that results in profound spatial cognitive deficits. We examined whether individuals with WS have intact perception of biological motion, which requires global spatial integration of local motion signals into a unitary percept of a human form. Children with WS, normal mental-age-matched children, and normal adults viewed point-light-walker (PLW) displays portraying a human figure walking to the left or right. Children with WS were as good as or better than control children in their ability to judge the walker's direction, even when it was masked with dynamic noise that mimicked the local motion of the PLW lights. These results show that mechanisms underlying the perception of at least some kinds of biological motion are unimpaired in children with WS. They provide the first evidence of selective sparing of a specialized spatial system in individuals with a known genetic impairment.
Cerebral 31P Magnetic Resonance Spectroscopy and Systemic Acid-Base Balance during Hypoxia in Fetal Sheep

The purpose of this study was to investigate cerebral energy metabolism and acid-base homeostasis during impaired oxygen supply in fetal sheep. Systemic acid-base balance was correlated with the sequence in changes of cerebral phosphorus metabolite ratios and intracellular pH. Phosphorus magnetic resonance spectra were obtained from the brain of six fetal sheep simultaneously with repeated measurements of fetal arterial oxygen saturation and acid-base balance. Fetal hypoxia was induced by gradually reducing the oxygen supply to the anesthetized pregnant ewe to establish an intended arterial pH of 7.00 or lower. The ratio of phosphocreatine to inorganic phosphate decreased from 1.08 ± 0.10 (SD) during the control period to 0.77 ± 0.29 at an arterial pH between 7.20 and 7.25. The inorganic phosphate level became significantly increased at an arterial pH between 7.10 and 7.15 compared with control values. With ongoing arterial acidosis, cerebral intracellular pH decreased linearly with the arterial pH. At an arterial pH of 7.00, cerebral intracellular pH was decreased from 7.18 ± 0.03 to 6.71 ± 0.28, and phosphocreatine and nucleoside triphosphates levels were decreased significantly. In fetal sheep brain, cerebral oxidative phosphorylation (ratio of phosphocreatine to inorganic phosphate) is already affected at a mild arterial acidosis. At an arterial pH of 7.00 or lower, nucleoside triphosphates disappeared, which almost inevitably was followed by death in fetal sheep.
Genetic analysis of the Candida albicans biofilm transcription factor network using simple and complex haploinsufficiency

Biofilm formation by Candida albicans is a key aspect of its pathobiology and is regulated by an integrated network of transcription factors (Bcr1, Brg1, Efg1, Ndt80, Rob1, and Tec1). To understand the details of how the transcription factors function together to regulate biofilm formation, we used a systematic genetic interaction approach based on generating all possible double heterozygous mutants of the network genes and quantitatively analyzing the genetic interactions between them. Overall, the network is highly susceptible to genetic perturbation with the six network heterozygous mutants all showing alterations in biofilm formation (haploinsufficiency). In addition, many double heterozygous mutants are as severely affected as homozygous deletions. As a result, the network shows properties of a highly interdependent ‘small-world’ network that is highly efficient but not robust. In addition, these genetic interaction data indicate that TEC1 represents a network component whose expression is highly sensitive to small perturbations in the function of other networks TFs. We have also found that expression of ROB1 is dependent on both auto-regulation and cooperative interactions with other network TFs. Finally, the heterozygous NDT80 deletion mutant is hyperfilamentous under both biofilm and hyphae-inducing conditions in a TEC1-dependent manner. Taken together, genetic interaction analysis of this network has provided new insights into the functions of individual TFs as well as into the role of the overall network topology in its function.
The GATA1 mutation in an adult patient with acute megakaryoblastic leukemia not accompanying Down syndrome.

Mutations of the GATA1 gene, which is located on chromosome X, have been found in almost all cases of transient myeloproliferative disorder (TMD) and acute megakaryoblastic leukemia (AMKL) accompanying Down syndrome (DS). [1][1]-[6][2] No GATA1 mutations have been detected in patients with AMKL who
Physical Leisure-Time Activities and Long-Term Sick Leave: A 15-Month Prospective Study of Nurses’ Aides

Learning ObjectivesDescribe the findings of past studies relating physical activity to health status.Understand the ways in which nurses’ aides who engage in regular physical activity outside of work differ from those who do not.Explain the findings relating sick leave to specific forms of physical activity.Discuss the implications of this and similar studies regarding the relationship between non–work-related exertion and health benefits. The objective of the study was to determine the relationship between physical leisure-time activities and the occurrence of long-term sick leaves in nurses’ aides. Of 5563 Norwegian nurses’ aides who were not on sick leave when they completed a questionnaire in 1999, 4744 (85.3%) completed a second questionnaire 15 months later. Brisk walks (odds ratio [OR], 0.78; 95% confidence interval [CI], 0.63 to 0.98), aerobics or gymnastics (OR, 0.71; 95% CI, 0.49 to 1.02), and other physical leisure activities (OR, 0.81; 95% CI, 0.66 to 1.00) for 20 minutes or more at least once a week predicted fewer long-term sick leaves (>14 days), after adjustments for baseline health complaints, demographic and familial characteristics, former and current smoking, and work factors. In conclusion, regular physical leisure-time activity may be associated with a reduced risk of long-term sickness absence in nurses’ aides.
Predictors of optimal virological response to potent antiretroviral therapy.

BACKGROUND Current potent antiretroviral therapy (using a protease inhibitor and two nucleoside reverse transcriptase inhibitors) produces a durable suppression of HIV replication in less than 75% of treated patients. Identification of predictors of successful therapy might allow the development of improved strategies to increase response rates. METHODS We analyzed retrospectively the results from a multicenter, randomized, double-blind Phase III study of combination anti-HIV therapy with nelfinavir, zidovudine, and lamivudine to evaluate the relationship between virological response over 48 weeks of treatment to variables which could potentially serve as early predictors of long-term response. The goal was to produce long-term suppression of viral load to sensitive (<400 copies HIV RNA/ml) and ultrasensitive (<50 copies HIV RNA/ml) limits of quantification with the Amplicor PCR assay. FINDINGS Baseline viral load, the change in viral load over the first 4 weeks of treatment, the 2 h post-dose nelfinavir levels and the time to respond to HIV RNA levels of <400 copies/ml and <50 copies/ml have the best predictive value in determining response and response duration. Patients who achieved very low viral nadirs (<50 copies HIV RNA/ml) had significantly longer responses than those who achieved nadirs of 50-400 copies HIV RNA/ml. INTERPRETATION Parameters that can be measured easily at baseline or early after therapy is started can identify patients at high risk of failure with standard treatment. Such patients may be candidates for more aggressive therapy or for alternative strategies designed to improve outcome. In addition, these results support the use of ultra-sensitive HIV RNA assays to predict long-term outcome of anti-HIV therapy.
Aleutian mink disease parvovirus infection of mink macrophages and human macrophage cell line U937: demonstration of antibody-dependent enhancement of infection

Aleutian mink disease parvovirus (ADV) infects macrophages in adult mink. The virulent ADV-Utah I strain, but not the cell culture-adapted ADV-G strain, infects mink peritoneal macrophage cultures and the human macrophage cell line U937 in vitro. However, preincubation of ADV-G with ADV-infected mink serum enhanced its infectivity for U937 cells. the enhancing activity was present in the protein A-binding immunoglobulin G fraction in the serum, but F(ab')2 fragments failed to enhance the infection. On the other hand, the same sera inhibited ADV-G infection of Crandell feline kidney (CRFK) cells. Although U937 cells were not fully permissive for antibody-enhanced ADV-G infection, ADV mRNA expression, genome amplification, and protein expression were identical to those found previously for ADV-Utah I infection of U937 cells. Preincubation of ADV-Utah I with soluble protein A partly inhibited the infection of U937 cells but did not affect infection of CRFK cells. In mink peritoneal macrophages, preincubation with the infected mink serum did not make ADV-G infectious. However, the infectivity for mink macrophages of antibody-free ADV-Utah I prepared from the lungs of infected newborn mink kits was enhanced by ADV-infected mink serum. Moreover, protein A partly blocked ADV-Utah I infection of mink macrophage cultures. These results suggested that ADV-Utah I enters mink macrophages and U937 cells via an Fc receptor-mediated mechanism. This mechanism, antibody-dependent enhancement, may also contribute to ADV infection in vivo. Furthermore, since ADV infection in mink is characterized by overproduction of anti-ADV immunoglobulins, antibody-dependent enhancement may play a critical role in the establishment of persistent infection with ADV in vivo.
Band-theory analysis of anisotropic transport in La2CuO

The anisotropic resistivity rho/sub . cap alpha. //sub . cap alpha. / and Hall coefficient R/sub . cap alpha. //sub . beta. //sub . gamma. / of La/sub 2-//sub x/M/sub x/CuO/sub 4/ are analyzed as a function of x, using a rigid-band treatment of the previously given linearized augmented plane-wave (LAPW) bands of tetragonal La/sub 2/CuO/sub 4/. The experimental rho/sub x//sub x/(T) is used to extract lambda/sub tr/approx. =3.8, which permits a conventional electron-phonon interpretation of the high T/sub c/. The Hall coefficients are qualitatively explained, including sign discrepancies in published measurements.
Blood lead levels in 2- to 3-year-old children in the Greater Bilbao Area (Basque Country, Spain): relation to dust and water lead levels.

The objectives of this study were to determine blood lead levels in 2-y-old children in the Greater Bilbao Area (Basque Country, Spain) and to compare those levels with the lead content of different media (i.e., house dust, park dust and soil, and water) in the child's environment. Between May and September of 1992, 138 children, aged 2 to 3 y, were studied. All children were attended by pediatricians within the public health-care network, and their parents volunteered for the study. A venous blood sample was drawn from each child and was analyzed for lead level, and the parents answered a questionnaire that addressed the socioeconomic background and habits of the children. The environment was investigated in 42 cases. Blood lead levels exceeded 15 micrograms/dl in 2% of the children, and 14% of the children had levels that exceeded 10 micrograms/dl (geometric mean = 5.7 micrograms/dl [4.7-6.7 micrograms/dl]. Blood lead levels were higher among (a) children whose mothers worked outside the home, (b) children whose fathers had only a primary-level education, and (c) children who lived in houses constructed prior to 1950. The geometrical averages of lead in house dust, park soil, and park dust were 595, 299, and 136 micrograms/g, respectively. Statistically significant linear correlation was found between blood lead level and lead content in park dust, a finding that explained a 9% variation in blood lead level; a subgroup of these children was also found to have a strong linear association between blood lead and lead content in house dust.
Exposing barriers to end-of-life communication in heart failure: an integrative review.

BACKGROUND End-of-life (EOL) communication is lacking despite patients with heart failure (HF) and their caregivers desiring it. AIM To review the existing literature to identify barriers that inhibit EOL communication in the HF population. METHOD We chose an integrative literature review method and began by searching CINAHL, Medline, PsychInfo, Web of Science, Health Source Nursing Academic, Evidence-Based Medicine Reviews (EBMR), dissertations and theses searches through the University of Victoria and through Proquest from 1995 to 2011. DATA EVALUATION: EOL communication regarding wishes, prognosis and options for care rarely happen. We noted that patients lacked understanding of HF, feared engaging health care professionals (HCP), did not wish to talk about EOL, or waited for HCPs to initiate the conversation. HCPs lacked communication skills, focused on curative therapies and found diagnosing and prognosticating HF difficult. Limited time and space for conversations played a role. CONCLUSION The challenge of diagnosing and prognosticating HF, its unpredictable trajectory, HCP inexperience in recognizing nearing EOL and lack of communication skills lead to HCPs avoiding EOL conversations. Four categories of barriers to communication were identified: patient/caregiver, HCP, disease-specific and organizational challenges.