Miracle-dz/UniFAR-FTUs huggingface dataset:
Association Between Impaired Vα7.2+CD161++CD8+ (MAIT) and Vα7.2+CD161-CD8+ T-Cell Populations and Gut Dysbiosis in Chronically HIV- and/or HCV-Infected Patients

Both HIV and HCV infections feature increased microbial translocation (MT) and gut dysbiosis that affect immune homeostasis and disease outcome. Given their commitment to antimicrobial mucosal immunity, we investigated mucosal-associated invariant T (MAIT) cells and Vα7. 2+CD161- T-cell frequency/function and their possible associations with MT and gut dysbiosis, in chronic HIV and/or HCV infections. We enrolled 56 virally infected (VI) patients (pts): 13 HIV+ on suppressive cART (HIV-RNA < 40cp/ml), 13 HCV+ naive to DAA (direct-acting antiviral) anti-HCV agents; 30 HCV+/HIV+ on suppressive cART and naive to anti-HCV. 13 age-matched healthy controls (HC) were enrolled. For Vα7. 2+CD161++ and Vα7. 2+CD161-CD8+ T cells we assessed: activation (CD69), exhaustion (PD1/CD39), and cytolytic activity (granzymeB/perforin). Following PMA/ionomycin and Escherichia coli stimulation we measured intracellular IL17/TNFα/IFNγ. Markers of microbial translocation (Plasma LPS, 16S rDNA, EndoCAb and I-FABP) were quantified. In 5 patients per group we assessed stool microbiota composition by 16S targeted metagenomics sequencing (alpha/beta diversity, relative abundance). Compared to controls, virally infected pts displayed significantly lower circulating Vα7. 2+CD161++CD8+ MAIT cells (p = 0.001), yet expressed higher perforin (p = 0.004) and granzyme B (p = 0.002) on CD8+ MAIT cells. Upon E. coli stimulation, the residual MAIT cells are less functional particularly those from HIV+/HCV+ patients. Conversely, in virally infected pts, Vα7. 2+CD161-CD8+ cells were comparable in frequency, highly activated/exhausted (CD69+: p = 0.002; PD-1+: p = 0.030) and with cytolytic potential (perforin+: p < 0.0001), yet were poorly responsive to ex vivo stimulation. A profound gut dysbiosis characterized virally infected pts, especially HCV+/HIV+ co-infected patients, delineating a Firmicutes-poor/Bacteroidetes-rich microbiota, with significant associations with MAIT cell frequency/function. Irrespective of mono/dual infection, HIV+ and HCV+ patients display depleted, yet activated/cytolytic MAIT cells with reduced ex vivo function, suggesting an impoverished pool, possibly due to continuous bacterial challenge. The MAIT cell ability to respond to bacterial stimulation correlates with the presence of Firmicutes and Bacteroidetes, possibly suggesting an association between gut dysbiosis and MAIT cell function and posing viral-mediated dysbiosis as a potential key player in the hampered anti-bacterial MAIT ability.
MRI-Derived Radiomics to Guide Post-operative Management for High-Risk Prostate Cancer

Purpose: Prostatectomy is one of the main therapeutic options for prostate cancer (PCa). Studies proved the benefit of adjuvant radiotherapy (aRT) on clinical outcomes, with more toxicities when compared to salvage radiotherapy. A better assessment of the likelihood of biochemical recurrence (BCR) would rationalize performing aRT. Our goal was to assess the prognostic value of MRI-derived radiomics on BCR for PCa with high recurrence risk. Methods: We retrospectively selected patients with a high recurrence risk (T3a/b or T4 and/or R1 and/or Gleason score>7) and excluded patients with a post-operative PSA > 0.04 ng/mL or a lymph-node involvement. We extracted IBSI-compliant radiomic features (shape and first order intensity metrics, as well as second and third order textural features) from tumors delineated in T2 and ADC sequences. After random division (training and testing sets) and machine learning based feature reduction, a univariate and multivariate Cox regression analysis was performed to identify independent factors. The correlation with BCR was assessed using AUC and prediction of biochemical relapse free survival (bRFS) with a Kaplan-Meier analysis. Results: One hundred seven patients were included. With a median follow-up of 52.0 months, 17 experienced BCR. In the training set, no clinical feature was correlated with BCR. One feature from ADC (SZEGLSZM) outperformed with an AUC of 0.79 and a HR 17.9 (p = 0.0001). Lower values of SZEGLSZM are associated with more heterogeneous tumors. In the testing set, this feature remained predictive of BCR and bRFS (AUC 0.76, p = 0.0236). Conclusion: One radiomic feature was predictive of BCR and bRFS after prostatectomy helping to guide post-operative management.
Fire in the Swamp Forest: Palaeoecological Insights Into Natural and Human-Induced Burning in Intact Tropical Peatlands

Tropical peat swamp forests are invaluable for their role in storing atmospheric carbon, notably in their unique below-ground reservoirs. Differing from terra firme forests, the peat-forming function of tropical swamps relies on the integrity of discrete hydrological units, in turn intricately linked to the above-ground woody and herbaceous vegetation. Contemporary changes at a local, e.g. fire, to global level, e.g. climatic change, are impacting in the integrity and functioning of these ecosystems. In order to determine to what extent and predict their likely future response, it is essential to understand past ecosystem disturbance and resilience. Here, we explore the impact of burning on tropical peat swamp forests. Fires within degraded tropical peatlands are now commonplace; whilst fires within intact peat swamp forests are thought to be rare events. Yet little is known about their long-term natural fire regime. Using fossil pollen and charcoal data from three peat cores collected from Sarawak, Malaysian Borneo, we looked at the incidence and impact of local and regional fire on coastal peat swamp forests over the last 7000 years. Palaeoecological results demonstrate that burning has occurred in these wetland ecosystems throughout their history, with peaks corresponding to periods of strengthened ENSO. However, prior to the Colonial era c. 1839 when human presence in the coastal swamp forests was relatively minimal, neither local nor regional burning significantly impacted on the forest vegetation. After the mid-19th Century, at the onset of intensified land-use change, fire incidence elevated significantly within the peatlands. Although fire does not correlate with past vegetation changes, the long-term data reveal that open vegetation, a proxy for human forest clearance, does follow a similar pattern. Our results suggest that human activity may be strongly influencing and acting synergistically with fire in the recent past, leading to the enhanced degradation of these peatland ecosystems. However, intact tropical peat swamp forests can and did recover from local fire events. These findings support present-day concerns about the increase in fire incidence and combined impacts of fire, human disturbance and El Nino on peat swamp forests, with serious implications for biodiversity, human health and global climate change.
Creative Flexibility Performance Is Neither Related to Anxiety, Nor to Self-Control Strength, Nor to Their Interaction

Previous research has reliably found that self-control strength moderates the anxiety-performance relationship for cognitive and perceptual-motor tasks that involve executive functioning. In the present preregistered experiment (N = 200; https://aspredicted.org/a775h.pdf), we investigated whether the interaction of anxiety and self-control also predicts creative flexibility performance. According to the Attentional Control Theory, anxiety can impair executive functioning. In the case that creative flexibility relies on executive functions, anxiety should therefore interfere with creative flexibility performance. However, self-control strength has been demonstrated to serve as a buffer against the negative effects of anxiety on executive functioning. Therefore, we assumed that there will be a negative relationship between anxiety and creative flexibility performance, and that this negative relationship would be more pronounced for participants who are low compared to high in momentary self-control strength. Analogous to the previous studies, we manipulated the participants’ self-control strength (ego depletion vs. no depletion) and subsequently induced a potentially threatening test situation. The participants then completed a measure of their state anxiety and a standardized test of creative flexibility. Contrary to our expectation, self-control strength, state anxiety, and their interaction did not predict creative flexibility performance. Complementary Bayesian hypothesis testing revealed strong support for the null hypothesis. Therefore, we conclude that, at least under certain conditions, creative flexibility performance may be unrelated to resource-dependent executive functions.
Amplitude-Integrated EEG for Neurological Assessment and Seizure Detection in a German Pediatric Intensive Care Unit

Objective: The aim of our study was to assess the use of aEEG in our pediatric intensive care unit (PICU), indications for neuromonitoring and its findings, utility for seizure detection, and associations with outcome. Design: We retrospectively analyzed non-neonates who were treated in our PICU and received amplitude-integrated EEG (aEEG). Patients: 27 patients aged between 29 days and 10 0/12 years (median 7.3 months) were included, who received a total of 35 aEEGS. Measurements: aEEG tracings were assessed for background (BG) pattern and its evolution, seizures, and side differences using a visual classification (Hellström-Westas). Clinical data were collected from patients' histories and analyzed for correlation with aEEG findings. Main results: While rare in early years, there was an increase in use over time. Most aEEGs were conducted because of (suspected) seizures or for management of antiepileptic treatment. aEEG had low sensitivity but high specificity for recognition of pathological BG pattern with reference to conventional EEG. Worsening of BG pattern or failure to improve was associated with death. Seizure detection rates by aEEG were higher than by clinical observation, especially for identification of non-convulsive epileptic state (ES). Side differences in aEEG were rare, but if present, they were associated with unilateral brain injury. Conclusions: aEEG is useful for the detection of seizures and ES in pediatric intensive care patients. Abnormal BG pattern and poor evolution of BG are negatively associated with survival. aEEG is a potential supplement to conventional EEG, facilitating long-term surveillance of cerebral function when continuous full-channel EEG is not available. Further investigation is needed.
New Insights Into Implementation of Mesenchymal Stem Cells in Cancer Therapy: Prospects for Anti-angiogenesis Treatment

Tumor microenvironment interacts with tumor cells, establishing an atmosphere to contribute or suppress the tumor development. Among the cells which play a role in the tumor microenvironment, mesenchymal stem cells (MSCs) have been demonstrated to possess the ability to orchestrate the fate of tumor cells, drawing the attention to the field. MSCs have been considered as cells with double-bladed effects, implicating either tumorigenic or anti-tumor activity. On the other side, the promising potential of MSCs in treating human cancer cells has been observed from the clinical studies. Among the beneficial characteristics of MSCs is the natural tumor-trophic migration ability, providing facility for drug delivery and, therefore, targeted treatment to detach tumor and metastatic cells. Moreover, these cells have been the target of engineering approaches, due to their easily implemented traits, in order to obtain the desired expression of anti-angiogenic, anti-proliferative, and pro-apoptotic properties, according to the tumor type. Tumor angiogenesis is the key characteristic of tumor progression and metastasis. Manipulation of angiogenesis has become an attractive approach for cancer therapy since the introduction of the first angiogenesis inhibitor, namely bevacizumab, for metastatic colorectal cancer therapy. This review tries to conclude the approaches, with focus on anti-angiogenesis approach, in implementing the MSCs to combat against tumor cell progression.
Personality and Psychological Factors of Problematic Internet Gamers Seeking Hospital Treatment

Introduction: Previous studies on internet gaming disorder (IGD) have reported an association between personality traits and impulsive or problematic use of the internet or internet games, but the results obtained were inconsistent. Our study’s hypothesis was that personality traits are associated with the individual’s choice to play internet games, and psychological status of the individual is associated with seeking treatment for addictive behavior at a hospital. Method: In the current study, individuals who reported excessive internet gaming and visited the hospital for treatment were enrolled and defined as the problematic internet gaming group; through advertisement, additional 138 individuals who were frequent gamers and 139 who were infrequent gamers were recruited. In a multiple logistic regression analysis of all participants’ data, a discrete set of hierarchical variables, with gaming preference (frequent gamers + problematic gamers) or problematic internet gaming as the dependent variable, was added to the demographic factors for model 1, personality traits for model 2, and psychological state for model 3. Results: Temperament was a potential factor associated with internet gaming preference. Additionally, model 2, which comprised both demographic factors and personality traits, was a significant factor to enhance the predictability of internet gaming preference with maximum accuracy of 96.7%. Of the three models in the current study, model 2 and model 3 with combined model 2 and patient’s psychological status were associated with problematic internet gaming. Discussion: The current study indicated that personality traits were potential factors associated with the individual’s preference for gaming. In addition, abnormal psychological status, especially, depressive mood and attention deficit, may lead individuals with problematic internet gaming to seek treatment at the hospital.
Immunotherapy in People With HIV and Cancer

HIV infection alters the natural history of several cancers, in large part due to its effect on the immune system. Immune function in people living with HIV may vary from normal to highly dysfunctional and is largely dependent on the timing of initiation (and continuation) of effective antiretroviral therapy (ART). An individual's level of immune function in turn affects their cancer risk, management, and outcomes. HIV-associated lymphocytopenia and immune dysregulation permit immune evasion of oncogenic viruses and premalignant lesions and are associated with inferior outcomes in people with established cancers. Various types of immunotherapy, including monoclonal antibodies, interferon, cytokines, immunomodulatory drugs, allogeneic hematopoietic stem cell transplant, and most importantly ART have shown efficacy in HIV-related cancer. Emerging data suggest that checkpoint inhibitors targeting the PD-1/PD-L1 pathway can be safe and effective in people with HIV and cancer. Furthermore, some cancer immunotherapies may also affect HIV persistence by influencing HIV latency and HIV-specific immunity. Studying immunotherapy in people with HIV and cancer will advance clinical care of all people living with HIV and presents a unique opportunity to gain insight into mechanisms for HIV eradication.
Neptunium(Y) and Neptunium(VI) Solubilities in Synthetic Brines of Interest to the Waste Isolation Pilot Plant (WIPP)

The solubility of Np(V) and Np(VI) has been measured in three synthetic Na-K-Mg-Cl brines in the presence of C02(g). Experiments were prepared from oversaturation by adding an excess of NpOJ or NpOj" to the brines and allowing the neptunium solids to precipitate. Vessels were maintained in contact with fixed C02(g) partial pressures at constant pH and 24 ±1 °C. Dissolved Np(V) concentrations decreased several orders of magnitude within the first 100 days of the experiment, while dissolved Np(VI) concentrations decreased initially but then remained relatively constant for more than 400 days. The solid phases formed in all experiments were identified by X-ray powder diffraction as KNp02C0, · XH20(S). Steady state concentrations for Np(V) are similar to those observed for Pu(V) in the same brines under the same conditions, where Pu occurs predominantly as Pu(V). Similarly, steady state concentrations for Np(VI), which was not reduced over a two year period, compare well with measured Pu(VI) concentrations in the same brines before the Pu(VI) was reduced to Pu(V).
NUMERICAL MODELLING OF CREEP DEFORMATION IN A CMSX-4 SINGLE CRYSTAL SUPERALLOY TURBINE BLADE

The creep deformation behaviour of a high pressure (cooled) turbine blade section is modelled using the finite element method. Realistic estimates of the thermal and mechanical loading expected during service are employed; properties for the single crystal superalloy CMSX4 are assumed. The constitutive model accounts for both a tertiary creep in the matrix and a
Wave Equations for the Heat Flux and the Pressure Tensor in Non-Equilibrium Thermodynamics

In this work, we develop for a complex fluid without structure evolution equations for the heat flux and the pressure stress tensor and its trace. With this set of equations, we obtain a telegrapher's type wave equation for each variable coupled to forced terms of the other variable. It is useful to express the evolution equations as wave equations because they allow us to have a better understanding of the non-equilibrium phenomena and with the help of propagation laws for waves, it is possible to analyze the response of the fluid to small local or instaneous perturbations in a minute region. Moreover, our results can be identified with three propagation velocities having thermofluidic effects. These results are different from those experimentally found by D.K. Banerjee et al. [1] in an anisotropic solid when heat pulses are applied. We also compare our wave equation for the heat flux with that one obtained by Guyer and Krumhansl [2] for the case of an isotropic medium.
Assessment of Some Agarophytes from the Coastal Areas of Iloilo, Philippines. II. Seasonal Variations in the Agar Quality of Gracilaria changii, Gracilaria manilaensis and Gracilariopsis bailinae (Gracilariales, Rhodophyta)

Three species of agarophytes (Gracilaria changii, G. mamlaensis and Gradlariopsis bailinae) collected along the mud flats of Iloilo were investigated to determine the monthly variation in agar yield (%), gel strength (gem""), gelling and melting temperatures (°C) and sulfate content ^gmg")· Results show that Gracilariopsis bailinae collected at Zarraga gave a higher gel strength (784 g cm") than that collected at Estancia (637 g cm"), however, the latter gave a higher agar yield (22%). A year-round source of agar was demonstrated in G. bailinae in both places while Gracilaria changii (January to June) and G. manilaensis (April to June) were seasonal. Higher agar yield and gel strength were measured from G. changii than in G. manilaensis. Gradlariopsis bailinae showed agar qualities superior to those of the two other species, hence it is a good species to harvest and develop for mariculture and consequently for agar manufacture.
Clay minerals in recent sediments of the continental shelf and the Bay of Cádiz (SW Spain)

Abstract The distribution of clay minerals in recent sediments on the continental shelf and in the Bay of Cádiz has been analysed as part of a wider study of sedimentary exchange between the continent and the continental margin. The clay minerals included in the muddy sediments consist mainly of illite, kaolinite, smectite, randomly mixed-layered illite-smectite, chlorite, vermiculite and randomly mixed-layered illite-chlorite. Distribution of the minerals indicates that inheritance from the adjacent continental areas is the most important process involved. The relations between the clay minerals were established by Q-mode and R-mode factor analysis. The main clay mineral associations are: (1) illite-kaolinite, (2) smectite-random mixed-layered illite-smectite, and (3) kaolinite-random mixed-layered illite-smectite-vermiculite. The main sources of sediment supply to the continental shelf are the Guadalquivir and Guadiana rivers. Sediment from these rivers and from the rivers flowing into the Bay of Cádiz (mainly the Guadalete) is transported to the part of the shelf outside the bay by ebb-tide currents. The path of this outflow to the continental shelf, where the sediment is partially deposited, is influenced by the morphology of the coast and by hydrodynamic processes.
Heavy Drinking and Non-Medical Use of Prescription Drugs among University Students: A 9-Year Follow-Up

Purpose: Investigations suggest non-medical use of prescription drugs (NMUPD) is associated with heavy drinking and polydrug use among university students. Our aim is to determine the prevalence of NMUPD among university students and to analyze its association with alcohol, tobacco, and cannabis use, and to study the role of the age of drinking onset. Methods: Cohort study among university Spanish students (n = 1382). Heavy drinking (HED) and risky consumption (RC) were measured with the Alcohol Use Disorders Identification Test. Questions related to tobacco and cannabis consumption were also formulated. NMUPD refers to sedative, anxiety, or pain medication intake within the last 15 days without medical prescription. All variables were measured at 18, 20, and 27 years. Multilevel logistic regression for repeated measures was used to obtain adjusted OR (odds ratios). We analyzed the results from a gender perspective. Results: Prevalence of NMUPD were higher in students who already partook in NMUPD at the beginning of the study. NMUPD in women at 27 is 3 times higher than at 18, while in men it is twice. Among females, RC (OR = 1.43) and cannabis consumption (OR = 1.33) are risk factors for NMUPD, while later onset of alcohol use (OR = 0.66) constitutes a protective factor. No significant differences were found for males. Conclusions: NMUPD is prevalent among university students. RC and early onset of alcohol use were associated with higher prevalence of NMUPD in females. The prevalence of NMUPD increased with age in both sexes. Strategies for reducing risky drinking and delaying onset of drinking should be provided for university students. Pharmacists and parents should be alerted to the risk of NMUPD.