Miracle-dz/UniFAR-FTUs huggingface dataset:
The thymidylate synthase tandem repeat promoter polymorphism: A predictor for tumor‐related survival in neoadjuvant treated locally advanced gastric cancer

We evaluated DNA polymorphisms in the thymidylate synthase (TS) and 5,10‐methylene‐tetrahydrofolate reductase (MTHFR) genes for an association with response and survival in locally advanced gastric cancer treated with 5‐FU based preoperative chemotherapy (CTx). DNA of 238 patients (CTx‐group: total n = 135, completely resected (R0) n = 102; without CTx: R0 n = 103) was isolated from blood or from nontumorous tissues. In the CTx‐group, genotyping of the tandem repeat and the G/C polymorphism in the triple repeat in the promoter region of the TS gene and of the C677T polymorphism of the MTHFR gene was performed. None of the TS or MTHFR genotypes were associated with histopathological response and only the TS tandem repeat polymorphism was significantly related to survival (all patients n = 135, p = 0.002; R0 resected patients n = 102, p = 0.007; log‐rank test). Multivariate analysis revealed ypN (p < 0.001) and the TS tandem repeat polymorphism as independent prognostic factors in the CTx‐R0‐group (p = 0.003). Analyzing the prognostic significance of the TS polymorphisms in the R0‐group without CTx, TS genotypes were not significantly associated with survival. Comparing survival between R0 patients with and without CTx in the respective TS genotype groups of the tandem repeat polymorphism, a significant survival benefit for the patients with CTx was found for the 2rpt/2rpt (n = 49; p = 0.002) and 2rpt/3rpt genotypes (n = 99; p = 0.004), but not for the 3rpt/3rpt genotype (n = 57; p = 0.93). Patients' survival after CTx was associated with the TS tandem repeat polymorphism. CTx did not improve survival of patients with the 3rpt/3rpt genotype. Thus, a different therapy might be more appropriate for these patients. © 2006 Wiley‐Liss, Inc.
The Antecedents of Transaction Costs in Digital Ecosystems: A Configurational View on the Interplay of App Architecture and Platform Governance

The locus of value creation and innovation in the software industry is shifting more and more to platform ecosystems on which numerous developers create extensions with additional functionalities based on the platforms core architecture. While such complementors may strongly profit from platforms, there are considerable costs. Recent studies therefore examined the costs of fitting apps to the specifications of certain platforms; however, these works largely neglect costs arising from the transactional relationship between platform and complementor. In order to shed light on this, our work examines how design choices of platform governance and app architecture impact the emergence of four types of cost-inducing hazards within the transactional context of the ecosystem. By using a configurational approach based on fuzzy-set qualitative comparative analysis (FsQCA), we display complex interactional effects of the causal conditions on complementors’ perception of hazardous environments and thus provide valuable insights for both practice and theory on platform ecosystems.
Mental health of internally displaced persons in Jalozai camp, Pakistan

Background: Internal displacement has been a distressing issue of Pakistan for last one decade. Few research works have been conducted on the psychological issues of internally displaced persons in Pakistan. Aims: The current research was aimed at determining the psychological effects of internal displacement, that is, psychological well-being, depression, anxiety and stress (internalizing problems) of the individuals who were displaced as a result of an armed conflict in Swat. Method: A sample of 126 internally displaced persons was taken from Jalozai camp which included females (n = 65) and males (n = 61). Age of the sample ranged from 20 to 75 years with a mean of 47.5 years. Translated and adapted versions of Well-Being Affectometer-2 Scale and Depression Anxiety Stress Scale were used in the current research. Results: Results of the study indicated differences between males and females, females being higher on internalizing problems and lower on psychological well-being, whereas family loss during displacement affected the results in the same way. Well-being, gender and family loss emerged as significant predictors of internalizing problems, and gender moderated the relationship between well-being and internalizing problems. Conclusion: Internal displacement may bring psychological issues for internally displaced persons, that is, their well-being may decrease and depression, anxiety and stress may increase during displacement. Limitations and implications of the study were discussed further.
Therapeutic Efficacies of GW471552 and GW471558, Two New Azasordarin Derivatives, against Pneumocystosis in Two Immunosuppressed-Rat Models

ABSTRACT Two new azasordarins, GW471552 and GW471558, were studied in vivo for treatment of Pneumocystis carinii pneumonia. In the Wistar rat spontaneous pneumonia model, both azasordarins significantly reduced the number of P. carinii cysts per gram of lung homogenate when administered at 1 mg/kg of body weight twice a day for 10 days. In a nude rat inoculation model, both compounds showed therapeutic efficacy at 0.25 mg/kg twice a day for 10 days.
On Rationality in The Traveler’s Dilemma

espanolKaushik Basu presenta el dilema del viajero (DV) como un desafio a la teoria de juegos. El desafio ha sido investigado experimentalmente. Al enfrentarse a la version de Basu del DV o similares, los participantes (incluyendo a expertos en teoria de juegos) se comportan como sugiere Basu. Sin embargo, un pequeno cambio en el juego tiene como consecuencia revertir las tendencias de eleccion. La cuestion es, entonces, si es posible brindar una explicacion de los principales hallazgos empiricos como consecuencias de decisiones racionales (es decir, racionalizarlos). Hay varias propuestas en la literatura pero ninguna provee una explicacion satisfactoria de por que expertos en teoria de juegos jugando entre si usualmente rechazan la unica estrategia no dominada del DV. El objetivo de este articulo es sugerir una propuesta alternativa que solucione este problema. EnglishKaushik Basu presents the Traveler’s Dilemma (TD) as a challenge to Game Theory. This challenge has been experimentally investigated. When faced with Basu’s version of the TD, participants (including experts in game theory) behave in the way Basu suggests. However, a little change in the game turns out to reverse participants’ choices. The question is, then, whether it is possible to provide an account of the main empirical findings as consequences of rational choices (i.e., to rationalize them). There are several proposals in the literature but none of them provides a satisfactory account for why experts in game theory playing against each other usually reject the only undominated option of the TD. The goal of this article is to suggest an alternative proposal that fixes this problem.
Mental health in pediatric settings: distribution of disorders and factors related to service use.

OBJECTIVES To examine child psychiatric disorders in pediatric settings and identify factors associated with parents' use of pediatricians as resources concerning emotional/behavioral issues and use of mental health services. METHOD The sample consists of 5- to 9-year-olds (mean = 7.17 years, SD = 1.41) from a representative sample (N = 1,060) of pediatric practices. Parent interviews included assessments of psychiatric disorders with the Diagnostic Interview Schedule for Children (DISC-R), parental depression/anxiety, possible child abuse, stress, support, and the use of mental health services. RESULTS The prevalence of any DISC disorder was 16.8%. Parental depression/anxiety and possible child abuse were associated independently with 2- to 3-times higher rates of disorder. Many parents (55%) who reported any disorder did not report discussing behavioral/emotional concerns with their pediatrician. Factors associated with discussing behavioral/emotional issues were the presence of any disorder and financial stress. Factors related to seeing a mental health professional were discussing behavioral/emotional issues with the pediatrician, single parenthood, and stressful life events. CONCLUSIONS The prevalence rates of disorders in this setting suggest that pediatricians are well-placed to identify and refer children with psychiatric disorders. However, most parents do not discuss behavioral/emotional issues with their pediatrician. Methods for improving rates of identification and referral (e.g., routine screening) are considered.
Activity of Long-Chain Acyl-CoA Synthetase Is Required for Maintaining Meiotic Arrest in Xenopus laevis1

ABSTRACT In most vertebrates, fully grown oocytes are arrested in meiotic prophase I and only resume the cell cycle upon external stimuli, such as hormones. The proper arrest and resumption of the meiotic cycle is critical for reproduction. A GalphaS signaling pathway essential for the arrest is conserved in organisms from Xenopus to mouse and human. A previous gene association study implicated that mutations of human ACSL6 may be related to premature ovarian failure. However, functional roles of ACSL6 in human infertility have yet to be reported. In the present study, we found that triacsin C, a potent and specific inhibitor for ACSL, triggers maturation in Xenopus and mouse oocytes in the absence of hormone, suggesting ACSL activity is required for the oocyte arrest. In Xenopus, acsl1b may fulfill a major role in the process, because inhibition of acsl1b by knocking down its RNA results in abnormal acceleration of oocyte maturation. Such abnormally matured eggs cannot support early embryonic development. Moreover, direct inhibition of protein palmitoylation, which lies downstream of ACSLs, also causes oocyte maturation. Furthermore, palmitoylation of Galphas, which is essential for its function, is inhibited when the ACSL activity is blocked by triacsin C in Xenopus. Thus, disruption of ACSL activity causes inhibition of the Galphas signaling pathway in the oocytes, which may result in premature ovarian failure in human.
Incompetency to stand trial: is psychiatry necessary?

Although psychiatrists disagree about whether they should have a role in the courtroom, the legal system continues to ask their help in evaluating defendants' competency to stand trial. The authors present four case reports that illustrate how psychiatrists can and should participate in the legal process. They also suggest that psychiatrists may be able to help protect a defendant's right to a speedy trial by preventing unnecessary hospitalization.
Complete groin lymphadenectomy with preservation of the fascia lata in the treatment of vulvar carcinoma.

OBJECTIVE The goal of this study was to assess the local groin recurrence of vulvar carcinoma in patients treated by complete groin node dissection with preservation of the fascia lata (GNDPFL). METHODS This study is a retrospective chart review of 60 patients with Stage I-IV vulvar carcinoma who underwent radical vulvectomy and GNDPFL between 1990 and 1998. All superficial inguinal nodes and the deep femoral nodes on the anterior and medial surfaces of the femoral vein within the fossa ovalis were removed en bloc while sparing the fascia lata and the cribriform fascia over the femoral artery. RESULTS Of the 60 study patients, 14 patients had Stage I disease, 20 Stage II, 21 Stage III, and 5 Stage IV. The mean number of nodes removed was 10 per groin. Thirty-nine patients had benign nodes on groin dissection. None of these 39 patients developed cancer recurrence in the dissected groins. Twenty-one of the sixty study patients (34%) had malignant nodes on groin dissection. Of these 21 patients, 2 experienced cancer recurrence in the groins. Our study describes a groin recurrence rate of 7.6% in patients with fewer than three malignant unilateral groin nodes. Postoperatively, 13% of patients developed lymphedema and 15% formed lymphoceles. CONCLUSIONS The zero groin recurrence rate in patients with negative nodes and the low rate of recurrence in patients with positive nodes indicate that groin lymphadenectomy with preservation of fascia lata is complete, therapeutic, and comparable to radical techniques of lymphadenectomy involving skeletonization of femoral vessels, resection of fascia lata, and muscle transposition.
Determination of Gabapentin-lactam in Serum of Patients under Gabapentin Therapy

Summary Gabapentin (1 - (amino methyl) cyclohex-ane acetic acid, CAS 601 42-96-3, GBP, Ne-urontin™) and its derivative gabapentin-lactam (8-aza-spiro[5,4]decan-9-one, GBP-L) were determined by HPLC in the serum of patients with focal epilepsy treated with GBP. In patients in whom serum was acquired within 3 h after oral intake, GBP-L could be detected at concentrations up to 8.2 µmol/1. As GBP-L has been previously shown to exert neuroprotective effects in a similar concentration range, this finding suggests that clinically relevant effects of GBP-L may occur in patients treated with GBP. The possible neuroprotective efficacy of GBP-L should be the subject of further preclinical and clinical investigations.
Advances in the understanding of tendinopathies: a report on the Second Havemeyer Workshop on equine tendon disease.

Tendons are formed during the second half of embryonic developmentwhen tendon precursor cells deposit narrow-diameter (∼30 nm) collagenﬁbrils that are parallel to the long axis of the tissue. During post nataldevelopment, the narrow ﬁbrils are replaced by large-diameter (up to500 nm)ﬁbrils. Theabilityoftendontotransmitforcefrommuscletobone,and to dissipate forces during locomotion, is directly attributable to thecollagen ﬁbrils. How the ﬁbrils are synthesised, how they are alignedparallel to the tendon long axis, and how this arrangement can bereinstated during tendon healing are poorly understood. Ultrastructuralstudies of tendon lesions show the reappearance of narrow-diametercollagen ﬁbrils and cells with slender cytoplasmic protrusions (calledﬁbripositors) that normally only occur in tendon during embryonicdevelopment. Recapitulation of development is a hypothesis that isgaining increasing support from researchers of tendon disease. A betterunderstanding of the genetic, molecular and environmental cues duringembryonicdevelopmentisexpectedtoprovidebetterinsightsintohowtoimprove the rate and ﬁdelity of tendon repair in mature horses. Tendondevelopment can conveniently be considered to have an early ‘cellular’phaseandasubsequent‘matrix’phase.Inthematrix-dominatedphaseoftendon development 3D scanning electron microscopy of mouse tendonsuggests that ﬁbripositors of the cells are the site of new ﬁbril formationandthemechanicalinterfacebetweenthecellandtheextracellularmatrix.It is hypothesised that ﬁbripositors exert pulling forces on collagen ﬁbrils,and their cellular forces require functional myosin II, which is anintracellular molecular motor that is part of the actinomyosin system. Adetailed understanding of how cells set the tensional homeostasis oftendon is expected to lead to new strategies for regulating collagen ﬁbrilassemblyinhealthandintendinopathy.
Multiple cell targets for melatonin action in Xenopus laevis retina: Distribution of melatonin receptor immunoreactivity

In the retina of the African clawed frog (Xenopus laevis), melatonin is synthesized by the photoreceptors at night, and binds to receptors that likely mediate paracrine responses. Melatonin appears to alter the sensitivity of the retinal cells to light, and may play a key role in regulating important circadian events that occur in the eye. A polyclonal antibody was raised against a 13 amino acid peptide corresponding to a region of the third cytoplasmic loop of the Xenopus laevis Mel1c melatonin receptor. Western blot analysis revealed a major immunoreactive band of approximately 60 kD in neural retina and retinal pigment epithelium (RPE) membranes. Immunocytochemical labeling of sections of Xenopus eyes demonstrated intense melatonin receptor-like immunoreactivity in the inner plexiform layer (IPL). Immunolabeling with antibodies to glutamate decarboxylase (GAD) or tyrosine hydroxylase (TOH) appeared to co-localize with the melatonin receptor immunoreactivity in different sublaminas of the IPL. This suggests that both GABAergic and dopaminergic amacrine cells express melatonin receptor protein. There were also some melatonin receptor immunoreactive varicose fibers in the IPL that did not co-localize with either TOH or GAD, and may represent efferent fibers, since they could be followed into the optic nerve. Melatonin receptor immunoreactivity was also present on cell soma in the ganglion cell layer. Furthermore, a moderate level of melatonin receptor immunoreactivity was observed in the RPE and rod and cone photoreceptor cells. The presence of melatonin receptor immunoreactivity in these cells supports previous observations of melatonin receptor RNA expression in multiple cell types in the Xenopus retina. Expression of melatonin receptor protein in the photoreceptors suggests that melatonin may have a direct action on these cells.
Continuous glucose monitoring by intravenous microdialysis: influence of membrane length and dialysis flow rate

The benefit of tight glucose control in the intensive care unit is controversial. Part of the debate is around the frequency of glucose measurements, and therefore, a continuous glucose monitoring system is needed. Previously, we have shown that intravenous microdialysis has the potential for this purpose but that the accuracy must be improved. The aim of this study was to investigate the effects of the microdialysis membrane length and the perfusion rate on improving the accuracy.
Moduli potentials in string compactifications with fluxes: Mapping the discretuum

We find de Sitter and flat space solutions with all moduli stabilized in four dimensional supergravity theories derived from the heterotic and type II string theories, and explain how all the previously known obstacles to finding such solutions can be removed. Further, we argue that if the compact manifold allows a large enough space of discrete topological choices then it is possible to tune the parameters of the four dimensional supergravity such that a hierarchy is created and the solutions lie in the outer region of moduli space in which the compact volume is large in string units, the string coupling is weak, and string perturbation theory is valid. We show that at least two light chiral superfields are required for this scenario to work, however, one field is sufficient to obtain a minimum with an acceptably small and negative cosmological constant. We discuss cosmological issues of the scenario and the possible role of anthropic considerations in choosing the vacuum of the theory. We conclude that the most likely stable vacuua are in or near the central region of moduli space where string perturbation theory is not strictly valid, and that anthropic considerations cannot help much in choosing a vacuum.
Titanium elastic nailing radius and ulna fractures in adolescents

Over the last 40 years, anatomic reduction with plate stabilization has become the standard in adult patients with diaphyseal fractures of the radius and ulna. When operative fixation has been indicated in skeletally immature patients with these fractures, a variety of techniques have been reported, with intramedullary fixation becoming increasingly accepted. There is currently significant variability in the treatment of adolescents with forearm fractures. The purpose of this study was to investigate the clinical and radiographic outcomes in the adolescent population after intramedullary fixation of both bone forearm fractures. A retrospective review identified 32 patients 12–18 years of age who had undergone intramedullary fixation of both forearm bones in the past 20 years at our institution. Galeazzi, Monteggia, radial head, and distal metaphyseal fractures were excluded. Radiographic evaluation was performed to determine union and postoperative radial bow. Clinical follow-up was carried out for postoperative complications and range of motion of the wrist, forearm, and elbow. The mean age of the patients was 14.1 years. A total of 19 fractures were closed injuries, nine were grade 1, three were grade 2, and one fracture was a grade 3b. Of the patients, 15.6% had limited postoperative range of motion. All patients in the older age group, 15–18 years of age, had a normal range of motion. A decrease in radial bow was not associated with limitation in motion. There was a 98% union rate, and all unions occurred by 7.5 months. Only three major complications occurred, two refractures and one ulnar hardware migration, and subsequent radius nonunion occurred in the one grade 3b injury. Flexible intramedullary nailing of both bone forearm fractures provides reliable bony union and excellent postoperative clinical results in adolescents. Level of evidence, IV.
Outcomes of Bariatric Surgery in the Elderly

The Medicare Coverage Advisory Committee recently concluded that evidence supports the safety and effectiveness of bariatric surgery in the general adult population. However, more information is needed on the role of bariatric surgery in the elderly. The aim of this study was to examine the outcome of bariatric surgery in the elderly performed at academic centers. Using International Classification of Diseases, 9th Revision diagnosis and procedure codes, we obtained data from the University HealthSystem Consortium Clinical Data Base for all elderly (>60 years) and nonelderly (19–60 years) patients who underwent bariatric surgery for the treatment of morbid obesity between 1999 and 2005. Outcome measures, including patient characteristics, length of stay, 30-day readmission, morbidity, and observed and expected (risk-adjusted) mortality, were compared between groups. Bariatric surgery in the elderly represents 2.7 per cent (n = 1,339) of all bariatric operations being performed at academic centers. Of the 99 University HealthSystem Consortium centers performing bariatric surgery, 78 centers (79%) perform bariatric surgery in the elderly. Compared with nonelderly patients, elderly patients who underwent bariatric surgery had more comorbidities, longer lengths of stay (4.9 days vs 3.8 days, P < 0.01), more overall complications (18.9% vs 10.9%, P < 0.01), pulmonary complications (4.3% vs 2.3%, P < 0.01), hemorrhagic complications (2.5% vs 1.5%, P < 0.01), and wound complications (1.7% vs 1.0%). The in-hospital mortality rate was also higher in the elderly group (0.7% vs 0.3%, P = 0.03). When risk adjusted, the observed-to-expected mortality ratio for the elderly group was 0.9. In a subset of elderly patients with a pre-existing cardiac condition (n = 236), the in-hospital mortality was 4.7 per cent. Bariatric surgery in the elderly represents only a small fraction of the number of bariatric operations performed at academic centers. Although the morbidity and mortality is higher in the elderly, bariatric surgery in the elderly is considered as safe as other gastrointestinal procedures because the observed mortality is better than the expected (risk-adjusted) mortality.
ISDB-Tb transmission in software-defined radio

Software-Defined Radio (SDR) has become a great tool for fast prototyping and developing new devices for communications systems as well as for implementing flexible, multi-standards communication equipment. In the same pace, Digital Terrestrial Television Broadcasting (DTTB) has become ubiquitous throughout the world and is continuously in development. Integrated System Digital Broadcasting Terrestrial version B (ISDB-TB) uses Band Segmented Transmission - Orthogonal Frequency Division Multiplexing (BST-OFDM), and a powerful channel code and interleavers. In this article, a new implementation of ISDB-TB modulator with SDR is proposed to achieve real time transmission fully compliant with the ISDB-TB standards. Also the computational performance characteristics of each processing block is presented to compare the total CPU consumption used. The software was developed in the GNU Radio and is a valuable tool in research and educational fields of digital communication.