Miracle-dz/UniFAR-FTUs huggingface dataset:
Mesenchymal cells reactivate Snail1 expression to drive three-dimensional invasion programs

Epithelial–mesenchymal transition (EMT) is required for mesodermal differentiation during development. The zinc-finger transcription factor, Snail1, can trigger EMT and is sufficient to transcriptionally reprogram epithelial cells toward a mesenchymal phenotype during neoplasia and fibrosis. Whether Snail1 also regulates the behavior of terminally differentiated mesenchymal cells remains unexplored. Using a Snai1 conditional knockout model, we now identify Snail1 as a regulator of normal mesenchymal cell function. Snail1 expression in normal fibroblasts can be induced by agonists known to promote proliferation and invasion in vivo. When challenged within a tissue-like, three-dimensional extracellular matrix, Snail1-deficient fibroblasts exhibit global alterations in gene expression, which include defects in membrane type-1 matrix metalloproteinase (MT1-MMP)-dependent invasive activity. Snail1-deficient fibroblasts explanted atop the live chick chorioallantoic membrane lack tissue-invasive potential and fail to induce angiogenesis. These findings establish key functions for the EMT regulator Snail1 after terminal differentiation of mesenchymal cells.
THE INFLUENCE OF MATERNAL CARE IN SHAPING HUMAN SURVIVAL AND FERTILITY

Abstract The influence of maternal care on child survival has evolved throughout human history due to variation in altriciality, allocare, and maternal behaviors. Here, we study the impact of these factors on the force of selection acting on age-specific survival and fertility (measured with elasticity analysis) in a model that incorporates the dependence of child survival on maternal survival. Results reveal life-history changes that cannot be elucidated when considering child's survival independent of maternal survival: decrease of late fertility and increase of late survival, and concomitant decrease of early and late fertility. We also show that an increase of child altriciality in early humans might explain the main human life-history traits: a high life expectancy and postreproductive life; a long juvenile period and a higher, and narrowed, fertility at the peak of the reproductive period.
Dorsal finger texture recognition: Investigating fixed-length SURF

We seek to create fixed-length features from dorsal finger skin images extracted by the SURF interest point detector to combine it in the privacy enhancing helper data scheme. The source of the biometric samples is the GUC45 database which features finger vein, fingerprint and dorsal finger skin images for modality fusion. First, the region of interest (ROI) is extracted, after which SURF features are extracted, and finally two different approaches for creating fixed length feature vectors are applied. SURF performance on the ROI is comparable to the PolyU database reported in the literature, namely an equal error rate of 0.74%. Of the two explored approaches for fixed-length features creation, averaging the descriptor components proved the most successful, achieving an equal error rate of 11.72%. Potential run-time performance increases were discovered as a side-effect. Without changing the complexity of the SURF matching scheme, a reduction in run-time of 75%-80% has been achieved, with only minimal precision loss; EER increases from 0.74% to 1%. The complexity of the matching can be reduced from O(n2) to constant time, but at a higher precision cost and resulting in an EER of 16.51%.
Universal scheduler design on uniprocessors in supervisory control of discrete-event systems framework

This paper presents a framework for designing universal schedulers for real-time systems on uniprocessors based on supervisory control theory (SCT) for discrete-event systems. A universal scheduler nondeterministically selects a task for execution in such a way that all timing constraints are met in a minimally restrictive fashion, while it contains all feasible deterministic scheduling policies
Comparison between Caprini and Padua risk assessment models for hospitalized medical patients at risk for venous thromboembolism: a retrospective study.

OBJECTIVES This study aimed to evaluate the validity of the risk assessment model (RAM) of Caprini and Padua in identifying venous thromboembolism (VTE) among hospitalized medical patients. METHODS This retrospective study reviewed a total of 320 VTE and 320 non-VTE patients. Baseline demographics and clinical data of these patients were all recorded. The Caprini and Padua RAMs were implemented and the individual scores of each risk factor were summed to generate a cumulative risk score. Meanwhile, the sensitivity, specificity, and positive and negative predictive values of these two models were analysed. Receiver operating characteristic (ROC) curve was plotted to calculate the area under the curve (AUC) and the Youden index. RESULTS Significant differences were observed in risk factors between VTE and non-VTE patients. More VTE patients were classified into the high-superhigh risk level by the Caprini RAM than the Padua RAM (70.9 vs 23.4%, P < 0.01). The sensitivity and positive and negative predictive values in the Caprini RAM were higher than those in the Padua RAM (P < 0.05). However, the specificity of the Caprini RAM was lower than that of the Padua RAM (P < 0.01). The AUC and the Youden index were higher in the Caprini RAM than in the Padua RAM (P < 0.01), whereas the Youden index in the Padua RAM at critical point 4 was lower than that at critical point 3 (0.010 vs 0.140, P < 0.05). CONCLUSIONS The Caprini RAM was suggested to be more effective than the Padua RAM for identification of hospitalized medical patients at risk for VTE.
Socioeconomic and demographic differences in exposure to environmental tobacco smoke at work: the Scania Public Health Survey 2000

Background: A study was undertaken to investigate the sociodemographic distribution of workplace exposure to environmental tobacco smoke (ETS) in a Swedish working population sample. Methods: 8,270 individuals were assessed by questionnaire in the Scania Public Health Survey. The influence of sociodemographic factors on ETS exposure at work was investigated by multivariable regression analysis. Results: Individuals under 25 years old were at highest risk of ETS exposure. Male skilled manual workers and female unskilled manual workers had higher adjusted odds ratios (OR 4.0, 95% CI: 3.1 - 5.3 and OR 3.2, 95% CI: 2.2 - 4.7, respectively) of ETS exposure than non-manual high-level employees. Conclusions: ETS should be recognized as a factor contributing to health inequalities. Women of childbearing age need protective strategies.
An intracranial aneurysm in one identical twin, but no aneurysm in the other

Only seven pairs of identical twins with intracranial aneurysms have been reported in the literature. In six of these, both twins had aneurysms, but in one pair only one twin had an aneurysm. We present another such pair of identical twins 21 years of age of whom only one twin had an aneurysm. She presented with a subarachnoid haemorrhage. Four-vessel angiography showed one aneurysm on the internal carotid artery; the aneurysm was clipped. Four-vessel angiography in her identical twin sister revealed no aneurysms. We have reviewed the seven previous reports of identical twins with intracranial aneurysms. We conclude that in case of an aneurysm in one identical twin, the other twin should be examined.
Building Change-Readiness Capabilities in the IS Organization: Insights From the Bell Atlantic Experience

Change-readiness is the ability of an information systems (IS) organization to deliver strategic IT applications within short development cycle times by utilizing a highly skilled internal IS workforce. This paper examines two important questions: What are the design elements of a change-ready IS organization? How can transformations to such designs be effectively managed? Insights to these questions are generated through a case study of the conceptualization and implementation of an innovative organization design within a large IS unit at Bell Atlantic, a Regional Bell Operating Company. First, a rich description is provided of the components (strategy, structure, processes, people skills, reward systems) of a centers of excellence (CoE) design that has yielded measurable gains in IS performance. Then, an analysis of the two-year implementation of this CoE design is provided in terms of anticipated and unanticipated change actions, as well as a summary of "lessons learned. " The conclusion describes the design as a model worthy of consideration by other IS managers for developing change-readiness IT capabilities. Comparisons with other models for the IS organization are then drawn.
Pharmacokinetics and Pharmacodynamics of Drugs Commonly Used in Pregnancy and Parturition

The majority of pregnant women will be treated with a medication other than a vitamin supplement during their pregnancy. Almost half of these medications will be category C or D according to the former US Food and Drug Administration classification system, indicating a lack of human studies with animal studies suggesting adverse fetal effects (category C) or evidence of risk in humans (category D). Changes in maternal physiology alter drug bioavailability, distribution, clearance, and thus the drug half-life in often unpredictable ways. For many drugs, good pharmacokinetic and pharmacodynamic data in pregnancy and parturition are lacking. For other drugs, recent studies demonstrate major pharmacokinetic or pharmacodynamic changes that require dose adjustment in pregnancy, but current dosing guidelines do not reflect these data. In this review, we address the principles that underlie changes in pharmacology and physiology in pregnancy and provide information on drugs that anesthesiologists commonly encounter in treating pregnant patients.
Heterotopic gastric mucosa: A significant clinical entity

Objective. Despite the apparent lack of clinical interest in the inlet patches of heterotopic gastric mucosa (HGM) in the upper esophagus, the literature contains reports of complications associated with HGM. The aim of this study was to determine the prevalence and clinical importance of HGM in patients referred for upper gastrointestinal endoscopy (UGE). Material and methods. A total of 1033 consecutive outpatients referred for UGE were prospectively evaluated. Clinical, endoscopic and histologic findings were analyzed and 24-h double-channel pH-metry was performed on 20 patients with HGM. Results. Fifty-three patients (5.1%) had HGM lesions. Dysphagia was significantly more frequent in HGM patients (21% versus 4%; p<0.001). Five of the 20 patients who underwent pH-metry presented with acid secretion from HGMs. These five patients had inlet patches of greater size. Conclusions. HGMs of the upper esophagus are not infrequent, although generally small and asymptomatic. In cases of large HGMs, acid secretion capacity may cause upper esophageal disorders.
Using Just-in-Time Teaching and Peer Instruction in a Residency Program’s Core Curriculum: Enhancing Satisfaction, Engagement, and Retention

Purpose To assess use of the combined just-in-time teaching (JiTT) and peer instruction (PI) instructional strategy in a residency program’s core curriculum. Method In 2010–2011, JiTT/PI was piloted in 31 core curriculum sessions taught by 22 faculty in the Northwestern University Feinberg School of Medicine’s general surgery residency program. JiTT/PI required preliminary and categorical residents (n = 31) to complete Web-based study questions before weekly specialty topic sessions. Responses were examined by faculty members “just in time” to tailor session content to residents’ learning needs. In the sessions, residents answered multiple-choice questions (MCQs) using clickers and engaged in PI. Participants completed surveys assessing their perceptions of JiTT/PI. Videos were coded to assess resident engagement time in JiTT/PI sessions versus prior lecture-based sessions. Responses to topic session MCQs repeated in review sessions were evaluated to study retention. Results More than 70% of resident survey respondents indicated that JiTT/PI aided in the learning of key points. At least 90% of faculty survey respondents reported positive perceptions of aspects of the JiTT/PI strategy. Resident engagement time for JiTT/PI sessions was significantly greater than for prior lecture-based sessions (z = –2.4, P = .016). Significantly more review session MCQ responses were correct for residents who had attended corresponding JiTT/PI sessions than for residents who had not (chi-square = 13.7; df = 1; P < .001). Conclusions JiTT/PI increased learner participation, learner retention, and the amount of learner-centered time. JiTT/PI represents an effective approach for meaningful and active learning in core curriculum sessions.
Exchange of Lipooligosaccharide Synthesis Genes Creates Potential Guillain-Barré Syndrome-Inducible Strains of Campylobacter jejuni

ABSTRACT Human ganglioside-like structures, such as GM1, found on some Campylobacter jejuni strains have been linked to inducing the Guillain-Barré Syndrome (GBS). This study shows that a C. jejuni strain without GM1-like molecules acquired large DNA fragments, including lipooligosaccharide synthesis genes, from a strain expressing GM1-like molecules and consequently transformed into a number of potential GBS-inducible transformants, which exhibited a high degree of genetic and phenotypic diversity.
Dynamical Electron Backscatter Diffraction Patterns. Part I: Pattern Simulations

Abstract A new approach for the simulation of dynamic electron backscatter diffraction (EBSD) patterns is introduced. The computational approach merges deterministic dynamic electron-scattering computations based on Bloch waves with a stochastic Monte Carlo (MC) simulation of the energy, depth, and directional distributions of the backscattered electrons (BSEs). An efficient numerical scheme is introduced, based on a modified Lambert projection, for the computation of the scintillator electron count as a function of the position and orientation of the EBSD detector; the approach allows for the rapid computation of an individual EBSD pattern by bi-linear interpolation of a master EBSD pattern. The master pattern stores the BSE yield as a function of the electron exit direction and exit energy and is used along with weight factors extracted from the MC simulation to obtain energy-weighted simulated EBSD patterns. Example simulations for nickel yield realistic patterns and energy-dependent trends in pattern blurring versus filter window energies are in agreement with experimental energy-filtered EBSD observations reported in the literature.
Vancomycin Versus Linezolid in the Treatment of Methicillin-Resistant Staphylococcus aureus Nosocomial Pneumonia: Implications of the ZEPHyR Trial

In 2003, a retrospective trial comparing linezolid versus vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) showed improved survival in the linezolid group. This ted to the ZEPHyR (Linezolid in the Treatment of Subjects with Nosocomial Pneumonia Proven to Be Due to Methicillin-Resistant Staphylococcus aureus) trial comparing linezolid versus vancomycin for MRSA pneumonia, which showed a benefit for linezolid with respect to clinical response but without a survival advantage. Limitations of the study included unbalanced treatment groups at baseline and number of patients excluded to reach the per-protocol group. Results of the ZEPHyR trial do not support routine use of linezolid for the treatment of MRSA pneumonia
Pentoxifylline does not decrease short-term mortality but does reduce complications in patients with advanced cirrhosis.

BACKGROUND & AIMS Pentoxifylline, an inhibitor of tumor necrosis factor-alpha, is given to patients with liver diseases, but its effects in patients with advanced cirrhosis are unknown. We performed a randomized, placebo-controlled, double-blind trial of its effects in patients with cirrhosis. METHODS A total of 335 patients with cirrhosis (Child-Pugh class C) were assigned to groups given either pentoxifylline (400 mg, orally, 3 times daily; n = 164) or placebo (n = 171) for 6 months. The primary end point was mortality at 2 months. Secondary end points were mortality at 6 months and development of liver-related complications. RESULTS By 2 months, 28 patients in the pentoxifylline group (16.5%) and 31 in the placebo group (18.2%) had died (P = .84). At 6 months, 50 patients in the pentoxifylline group (30.0%) and 54 in the placebo group (31.5%) had died (P = .75). The proportions of patients without complications (eg, bacterial infection, renal insufficiency, hepatic encephalopathy, or gastrointestinal hemorrhage) were higher in the pentoxifylline group than in the placebo group at 2 months (78.6% vs 63.4%; P = .006) and 6 months (66.8% vs 49.7%; P = .002). The probability of survival without complications was higher in the pentoxifylline group than in the placebo group at 2 and 6 months (P = .04). In multivariate analysis, the factors associated with death were age, the Model for End-Stage Liver Disease score, and presence of early-stage carcinoma. Treatment with pentoxifylline was the only factor associated with liver-related complications. CONCLUSIONS Although pentoxifylline does not decrease short-term mortality in patients with advanced cirrhosis, it does reduce the risk of complications.
Functional performance of young children after traumatic brain injury: a 6-month follow-up study.

OBJECTIVES A follow-up study is reported of 40 children between the ages of 1 month and 5.6 years who had sustained a brain injury either with (n = 11) or without (n = 29) additional injuries. METHOD Children and their families were assessed at both 1 and 6 months after hospital discharge with standardized measures of functional performance and family functioning, including the Child Behavior Checklist, the Pediatric Evaluation of Disability Inventory, and the Impact on Family Scale. In addition to within-group analyses, functional outcome was compared to that of a group of 17 children who had sustained non-central nervous system injuries. RESULTS Mean scores for both groups of injured children were within the average range at both 1-month and 6-month follow-up testing. There was a general trend toward improved performance across the follow-up period, although only a few of these changes reached statistical significance. The effect of the injury as reported by the family was significantly associated with children's function as reflected by number of behavior problems and increased need for caregiver assistance. CONCLUSION Results point to the need for systematic follow-up of young children after brain injury using sensitive measures to enable early identification of children whose further development may be at risk and to provide support to families whose children are displaying changes in functional behavior.
A longer tracheal occlusion period results in increased lung growth in the nitrofen rat model

Prenatal tracheal occlusion (TO) promotes lung growth and is applied clinically in fetuses with severe congenital diaphragmatic hernia. Limited data are available regarding the effect of duration of TO on lung development. Our objective was to evaluate the effects of long (2 and 2.5 days) versus short (1 day) TO on lung development in rats with nitrofen‐induced diaphragmatic hernia.
Patterns of Gastroesophageal Reflux in Health and Disease

Twenty-four-hour pH monitoring of the distal esophagus quantitates gastroesophageal reflux in a near physiologic setting by measuring the frequency and duration of acid exposure to the esophageal mucosa. Fifteen asymptomatic volunteers were studied with 24-hour pH and esophageal manometry. The normal cardia was more competent supine than in the upright position. Physiologic reflux was unaffected by age, rarely occurred during slumber, and was the rule after alimentation. One hundred symptomatic patients with an abnormal 24-hour pH record (2 S.D. above the mean of controls) could be divided into three patterns of pathological reflux: those who refluxed only in the upright position (9), only in the supine position (37), and in both positions (54). Upright differed from supine refluxers by excessive aerophagia causing reflux episodes by repetitive belching. Compared to controls, they had excessive post-prandial reflux, lower DES pressure, and less DES exposed to the positive pressure of the abdomen. Supine differed from upright refluxers by having a higher incidence of esophagitis and an inability to clear the esophagus of acid after a supine reflux episode. Compared to controls, they had only a lower DES pressure. Combined refluxers had a higher incidence of esophagatis than supine refluxers. Stricture (15%) was seen only in this group. They were similar to supine refluxers in their inability to clear a supine reflux episode. Compared to controls, they had a lower DES pressure and less DES exposed to the positive pressure of the abdomen. Forty of the 100 patients had an antireflux procedure (4 upright, 8 supine, 28 combined). The most severe postoperative flatus and abdominal distention was seen in the upright refluxers. It is concluded that minimal reflux is physiological. Patients with pathological reflux all have lower DES pressure. Patients with upright reflux have less of their DES exposed to the positive pressure environment of the abdomen. Patients with supine reflux have an inability to clear the esophagus of reflux acid and are prone to develop esophagitis. Patients with both upright and supine reflux have the most severe disease and are at risk in developing strictures. In patients with only upright reflux, aerophagia and delayed gastric emptying may be an important etiological factor.
An audit of completeness of HIV clinical histories: before and after introduction of an HIV proforma

Summary The completeness of a ‘first consultation’ human immunodeficiency virus (HIV) clinical history before and after the introduction of an HIV proforma was audited by a retrospective case notes review. Twenty key variables considered essential to every history were assessed. There was a significant improvement in the documentation of 14 of the 18 items for men and 14 of the 20 items for women post-proforma with no deterioration in documentation of any of the variables. Our study supports the introduction of a structured ‘first consultation’ notes proforma for use during consultations with both newly diagnosed HIV-positive patients and those transferring their care from other centres.