Miracle-dz/UniFAR-FTUs huggingface dataset:
Regulation of follicle growth through hormonal factors and mechanical cues mediated by Hippo signaling pathway

ABSTRACT The ovary is an interesting organ that shows major structural changes within a short period of time during each reproductive cycle. Follicle development is controlled by local paracrine and systemic endocrine factors. Many hormonal and molecular analyses have been conducted to find the mechanisms underlying structural changes in ovaries, However, exact mechanisms still remain to be determined. Recent development of mechanobiology facilitates the understanding on the contribution of physical forces and changes in the mechanical properties of cells and tissues to physiology and pathophysiology. The Hippo signaling pathway is one of the key players in mechanotransduction, providing an understanding of the molecular mechanisms by which cells sense and respond to mechanical signals to regulate cell proliferation and apoptosis for maintaining optimal organ sizes. Our group recently demonstrated the involvement of the Hippo signaling pathway in the regulation of ovarian follicle development. Fragmentation of ovarian cortex into small cubes changed cytoskeletal actin dynamics and induced disruption of the Hippo signaling pathway, leading to the production of CCN growth factors and anti-apoptotic BIRC. These factors, in turn, stimulated secondary follicle growth in vitro and in vivo. In this review, we summarized hormonal regulation of follicular structural changes and further focused on the role of Hippo signaling in the regulation of follicle development. We also suggest a new strategy of infertility treatments in patients with polycystic ovary syndrome and primary ovarian insufficiency based on mechanobiology.
Serum IL‐6 levels and the risk for hepatocarcinogenesis in chronic hepatitis C patients: An analysis based on gender differences

Interleukin‐6 (IL‐6) may play a role in the pathogenesis of hepatocellular carcinoma (HCC). Recently, it was reported in mouse models that estrogen‐mediated inhibition of IL‐6 production explains the gender disparity in HCC. We conducted a retrospective cohort study to examine whether this hypothesis is applicable to human HCC. We enrolled 330 patients with chronic hepatitis C whose serum samples were collected between January 1994 and December 2002. Serum IL‐6 concentrations were measured and patients were divided into three groups according to IL‐6 levels: low, middle, and high. We evaluated the association between serum IL‐6 levels and the risk of subsequent HCC development, including subgroup analysis on each gender. During the follow‐up period (mean 9.0 yr), HCC developed in 126 patients. The incidence rates differed significantly among the three groups (p = 0.015), increasing in accordance with serum IL‐6 levels. However, unexpectedly, this tendency was significant only in female patients. In a multivariate analysis, higher serum IL‐6 level was an independent risk factor for HCC development in female patients, with a hazard ratio of 1.61. Although female patients showed a weak negative correlation between serum IL‐6 levels and estradiol levels, the lower risk of HCC in female patients cannot be fully explained by estrogen‐mediated inhibition of IL‐6 production. In conclusion, higher serum IL‐6 level was an independent risk factor for HCC development in female but not male chronic hepatitis C patients. Measurement of serum IL‐6 levels may provide useful information for predicting future HCC development in female chronic hepatitis C patients. © 2009 UICC
The Adjustment to Commodity Price Shocks in Chile, Colombia, and Peru

This paper presents a comparative analysis of the macroeconomic adjustment in Chile, Colombia, and Peru to commodity terms-of-trade shocks. The study is done in two steps: (i) an analysis of the impulse responses of key macroeconomic variables to terms-of-trade shocks and (ii) an event study of the adjustment to the recent decline in commodity prices. The experiences of these countries highlight the importance of flexible exchange rates to help with the adjustment to lower commodity prices, and staying vigilant in addressing depreciation pressures on inflation through tightening monetary policies. On the fiscal front, evidence shows that greater fiscal space, like in Chile and Peru, gives more room for accommodating terms-of-trade shocks.
Does R&D, human capital and FDI matter for TFP in OECD countries?

ABSTRACT This study investigates the interplay between research and development (R&D), human capital (HC), foreign direct investment (FDI) and total factor productivity (TFP) in OECD countries. We divide the sample into two sub-groups; the European and the non-European states so as to account for underlying country heterogeneity. The analysis follows a panel data approach over the period 1995–2015, taking into account the modelling on non-stationarity, long-run relationships and short-run dynamics with a panel VAR. Both R&D and HC have a positive effect on TFP, whilst FDI has a positive and significant effect only in the case of non-European countries. Moreover, the contribution of R&D is higher than that of HC and FDI in all cases. Thus, based on these findings, policymakers should design and implement policies to increase resources invested in R&D, with a consistent ongoing spending review, to attract foreign direct investment, especially for the majority of the European and some of the non-European countries and to improve education system on a more productive innovation and research base.
The traditional marketplace: serious leisure and recommending authentic travel

ABSTRACT Services reliant on revenue generated from tourism are often beholden to how authentic visitors perceive their offering to be. From a managerial perspective, this is exacerbated when they serve a dual-purpose, as both actively ingrained in local culture and showcased international tourist attractions. As such, this study contributes to Kolar and Žabkar’s (2010) consumer-based model of authenticity by assessing the relationships between serious leisure, object-based and existential authenticity, and visitor word-of-mouth (WOM) recommendations in Iranian cultural tourism. Utilising partial least-squares structural equation modelling, and drawing upon responses from 615 visitors to the Tabriz Grand Bazaar, it thus extends the model’s applicability to the developing Middle Eastern context. The results extend extant research by emphasising the importance of object-based authenticity, as opposed to existential authenticity, in stimulating positive visitor WOM recommendations. Consequently, this study advances the prevailing understanding of the role of authenticity in stimulating positive behavioural intentions by highlighting how destinations can stimulate visitor recommendations.
Effect of 6-Minute Colonoscopy Withdrawal Time Policy on Polyp Detection Rate in a Community Hospital

In 2002, a U.S. Multi-Society Task Force on colorectal cancer recommended a 6-minute or more withdrawal time as an indicator of a quality colonoscopy. In 2006, Barclay, Vicari, Daughty, Johanson, and Greenlaw (2006) found a correlation between longer withdrawal time and an increased rate in the detection of adenomas. In January 2008, the endoscopy department at our institution adopted the Multi-Society Task Force recommendation. The aim of our study was to evaluate the effect of a minimal 6-minute withdrawal time policy at our institution on polyp detection rate. All colonoscopies performed for screening indications from April 2007 to September 2008 were reviewed retrospectively. Group I (pre-policy) was compared with Group II (post-policy). Data collected included age, gender, indication, polyp detection rate, size, and withdrawal time. Unpaired t tests evaluated pre- and postprocedure results. Fisher's exact tests were used to compare detection rates between withdrawal time less than 6 minutes and more than 6 minutes. Mann–Whitney U Tests were performed to analyze the significance between the number of polyps detected for withdrawal time less than 6 minutes versus more than 6 minutes. A total of 1,342 colonoscopies were available for analysis in Group I and 1,316 in Group II. Polyp detection rate was 46.6% in Group I versus 48.2% in Group II (p = .39), a non-statistically significant difference; however, there was a trend toward identifying small- and medium-sized polyps in Group II. Small polyps can carry a risk of severe dysplasia (Church, 2004). Data were then analyzed for withdrawal time. The polyp detection rate was 20.9 in procedures that took less than 6 minutes versus 48.3 in those that took more than 6 minutes (p ⩽ .01). In this study, a 6-minute or more withdrawal time increased the polyp detection rate by 133% for all polyp sizes, especially small and medium. Small polyps (5 mm or less) should be removed and not ignored. A 6-minute or more withdrawal time should be mandatory in those patients without a previous colon resection.
Musical creativity and the embodied mind

The phenomenon of creativity has received a growing amount of attention from scholars working across a range of disciplines. While this research has produced many important insights, it has also traditionally tended to explore creativity in terms of the reception of products or outcomes, conceiving of it as a cognitive process that is limited to the individual domain of the creative agent. More recently, however, researchers have begun to develop perspectives on creativity that highlight the patterns of adaptive embodied interaction that occur between multiple agents, as well as the broader socio-material milieu they are situated in. This has promoted new understandings of creativity, which is now often considered as a distributed phenomenon. Because music involves such a wide range of socio-cultural, bodily, technological, and temporal dimensions it is increasingly taken as a paradigmatic example for researchers who wish to explore creativity from this more relational perspective. In this article, we aim to contribute to this project by discussing musical creativity in light of recent developments in embodied cognitive science. More specifically, we will attempt to frame an approach to musical creativity based in an 4E (embodied, embedded, enactive, and extended) understanding of cognition. We suggest that this approach may help us better understand creativity in terms of how interacting individuals and social groups bring forth worlds of meaning through shared, embodied processes of dynamic interactivity. We also explore how dynamical systems theory (DST) may offer useful tools for research and theory that align closely with the 4E perspective. To conclude, we summarize our discussion and suggest possibilities for future research.
An empirical investigation on the liquidity effects of monetary policy shocks on exchange rates

This paper examines recent work on the identification of monetary policy disturbances and the effect on the interest rates and exchange rate. A method of identifying monetary policy using non borrowed reserves is proposed. Under this specification, policy has strong persistent liquidity effects in interest and exchange rates. The fluctuation of the liquidity level impacts the level of the interest rates and spills over to the asset prices and to the foreign exchange market.
Cultural competency in the field of instructional leadership

As U.S. school systems are called upon to serve increasingly diverse student populations, school leaders must expand their roles to help teachers meet all students’ academic, social, and cultural needs. The purpose of this study was to examine culturally competent instructional leadership by interviewing principals and assistant principals known for their commitment to culturally responsive supervision. Eleven school leaders from four states participated in this indepth interview study. Using inductive, qualitative analysis, this interpretive study examined how the administrators learned these skills and modeled them for teachers through the practice of instructional supervision. A model was constructed to illustrate the key findings of the study, which were as follows: Leaders encountered inequity and differential treatment early in their lives or as new teachers, and these experiences ultimately shaped who they became as school supervisors. Leaders used culturally responsive pedagogies as teachers, and now build on those skills in their supervision practices. Leaders described what it meant to be culturally competent in their work as K-12 instructional supervisors and practiced awareness as a way to “know” their instructional supervision work. Leaders shared the importance of connecting professionally and
De Novo Truncating Mutations in the Kinetochore‐Microtubules Attachment Gene CHAMP1 Cause Syndromic Intellectual Disability

A rare syndromic form of intellectual disability with impaired speech was recently found associated with mutations in CHAMP1 (chromosome alignment‐maintaining phosphoprotein 1), the protein product of which is directly involved in microtubule‐kinetochore attachment. Through whole‐exome sequencing in six unrelated nonconsanguineous families having a sporadic case of intellectual disability, we identified six novel de novo truncating mutations in CHAMP1: c.1880C>G p.(Ser627*), c.1489C>T; p.(Arg497*), c. 1876_1877delAG; p.(Ser626Leufs*4), c.1043G>A; p.(Trp348*), c.1002G>A; p.(Trp334*), and c. 958_959delCC; p.(Pro320*). Our clinical observations confirm the phenotypic homogeneity of the syndrome, which represents therefore a distinct clinical entity. Besides, our functional studies show that CHAMP1 protein variants are delocalized from chromatin and are unable to bind to two of its direct partners, POGZ and HP1. These data suggest a pathogenic mechanism of the CHAMP1‐associated intellectual disability syndrome mediated by direct interacting partners of CHAMP1, several of which are involved in chromo/kinetochore‐related disorders.
Upregulation of rho A and rho kinase messenger RNAs in the basilar artery of a rat model of subarachnoid hemorrhage.

OBJECT Rho A, a small guanosine triphosphate-binding protein, and rho kinases have been suggested to play an important role in the agonist-induced myofilament Ca++ sensitization and cytoskeletal organization of smooth-muscle cells. To discover their possible roles in the prolonged contraction seen in cerebral vasospasm, the authors investigated the messenger (m)RNA expressions of rho A and rho-associated kinases alpha and beta in the basilar artery (BA) of a rat double cisternal blood-injection model. METHODS An experimental subarachnoid hemorrhage (SAH) was achieved in rats by twice injecting autologous arterial blood into the cisterna magna of each animal. The mRNAs for rho A and rho-associated kinases alpha and beta of the rat BA were analyzed using reverse transcription-polymerase chain reaction (RT-PCR). The cisternal blood injection induced a marked corrugation of elastic lamina and contraction of smooth-muscle cells observed with the aid of light and transmission electron microscopy in the rat BA on Days 3, 5, and 7. Results of the RT-PCR revealed that mRNAs for rho A and rho kinases alpha and beta were expressed in the rat BA and that they were significantly upregulated and reached their peaks on Day 5. CONCLUSIONS The mRNA upregulation of these proteins indicates that activation of rho A/rho kinase-related signal transduction pathways is involved in the development of long-lasting contraction of cerebral arteries after SAH.
Self-organisation in commons-based peer production : Drupal : "the drop is always moving".

Commons-Based Peer Production (CBPP) is a new model of socio-economic production in which groups of individuals cooperate with each other without a traditional hierarchical organisation to produce common and public goods, such as Wikipedia or GNU/Linux. There is a need to understand how these communities govern and organise themselves as they grow in size and complexity. Following an ethnographic approach, this thesis explores the emergence of and changes in the organisational structures and processes of Drupal: a large and global CBBP community which, over the past fifteen years, has coordinated the work of hundreds of thousands of participants to develop a technology which currently powers more than 2% of websites worldwide. Firstly, this thesis questions and studies the notion of contribution in CBPP communities, arguing that contribution should be understood as a set of meanings which are under constant negotiation between the participants according to their own internal logics of value. Following a constructivist approach, it shows the relevance played by less visible contribution activities such as the organisation of events. Secondly, this thesis explores the emergence and inner workings of the socio-technical systems which surround contributions related to the development of projects and the organisation of events. Two intertwined organisational dynamics were identified: formalisation in the organisational processes and decentralisation in decision-making. Finally, this thesis brings together the empirical data from this exploration of socio-technical systems with previous literature on self-organisation and organisation studies, to offer an account of how the organisational changes resulted in the emergence of a polycentric model of governance, in which different forms of organisation varying in their degree of organicity co-exist and influence each other.
‘When he’s up there he’s just happy and content’: Parents’ perceptions of therapeutic horseback riding

Background There is limited global and South African research on parents’ perceptions of therapeutic horseback riding (THR), as well as their perceptions of the effect of the activity on their children with disabilities. Objective To explore and describe parents’ perceptions and experiences of THR as an activity for their children with disabilities. Method Twelve parents whose children attend THR lessons at the South African Riding for the Disabled Association in Cape Town were asked to participate in a semi-structured interview. The qualitative data obtained from the interviews were first transcribed and then analysed using thematic analysis to establish parents’ perceptions of the THR activity. Results The main themes that emerged included parental perceived effects of THR on children, parents’ personal experiences of the services, and parents’ perceived reasons for improvements in the children. The participating parents indicated that THR had had a positive psychological, social and physical effect both on the children participating in the riding, as well as on the parents themselves. Conclusion According to parents, THR plays an important role in the lives of children with various disabilities and in the lives of their parents. The results of the study address the gap in the literature regarding parents’ perceptions of THR.
Pronorm and Antinorm Deviants: A Test of the Subjective Group Dynamics Model

The authors replicated the study by D. Abrams, J. M. Marques, N. Bown, and M. Henson (2000, Study 2), performed to test the subjective group dynamics model (J. M. Marques, D. Abrams, D. Paez, & C. Martinez-Taboada, 1998). Participants were students enrolled in the psychology department at an Italian university. The present study considered the relationship between students and professors, and the attitude object was limited enrollment for admission to the department. Participants evaluated either in-group or out-group members. Findings replicated those of Abrams et al., except the in-group pronorm deviant was perceived to be less typical and evaluated less positively than the normative members. This finding suggests that, during an intergroup conflict, perception of the typicality of deviants exaggerating the in-group norms—and thus their evaluations—may increase as long as deviance is not perceived to be too accentuated.
Effect of surface treatments of zirconia ceramics on the bond strength to resin cement.

PURPOSE The purpose of this in vitro study was to evaluate the bond strength of a resin luting cement to zirconia surfaces that had received two novel surface pretreatment methods: etching of a pre-fired overglaze or paste liner on the zirconia substrate. MATERIALS AND METHODS Fully sintered zirconia disks were assigned to 6 groups according to the surface pretreatment: firing of 2 layers of paste liner which was then etched with hydrofluoric acid and treated with silane (Liner group); firing of 2 layers of overglaze which were then etched with hydrofluoric acid and treated with silane (glaze group); Rocatec treatment and silane application (Rocatec group); Rocatec treatment followed by ultrasonic cleaning and silanization (ultrasonic-Rocatec group); sandblasted with alumina (alumina group); as-sintered with no pretreatment (control group). Twenty composite resin cylinders were bonded to each group with Panavia F 2.0. Each group was further divided into 2 subgroups (n = 10) for 2 different storage conditions: 24 h water storage or 3 weeks water storage plus 6000 thermocycles between 5°C and 55°C. The shear bond strength was then determined. Statistical analyses with two-way ANOVA were conducted; the level of significance was set at p < 0.05. RESULTS At 24 h, the shear bond strength values of all groups except the control showed no statistically significant difference. After artificial aging, the mean bond strength of all groups dropped, but the decrease in the glaze group was not statistically significant. The glaze group showed the highest shear bond strength. However, that was not statistically different from the liner or the Rocatec group without ultrasonic cleaning (p < 0.05). All the control specimens debonded spontaneously after aging. Ultrasonic cleaning after Rocatec treatment caused a reduction in shear bond strength, but the difference was not statistically significant. CONCLUSION Both the fired paste liner and overglazed ceramic treated zirconia surfaces provided a strong and durable bond to resin cement under the conditions tested.
A Phenomenological Study Examining the Journey of Identity Development for Internationally Adopted Adolescents in the United States

The purpose of this transcendental phenomenological study was to understand the perspectives of young adults who were internationally adopted to the United States during their adolescent years and to describe the experiences that contributed to their identity development. Erikson’s psychosocial development theory guided this study as it examined the relationships, roles, and values that humans commit to during the critical period of adolescence. Social identity theory furthered insight as to how individuals have defined themselves and their social categorization within groups, while the multiple dimensions of identity model helped define the key categories, themes, and contextual influences that have contributed to the adoptee’s psychological and social adjustment in their search for self. Thirteen participants were a purposefully selected sample of international adoptees who were ages 12–17 years at the time of adoption and have since graduated from high school or have obtained a General Equivalency Diploma (GED). Individuals were ages 18–26 years at the time of participation and had been residents of the United States for at least five years. Surveys, adoption records, semi-structured interviews, identity models, and advice letters were methods for collecting data of the adoptees’ experiences and perceptions. Significant statements were captured from the data and clustered into themes. The synthesis of textural and structural descriptions provided a basis for understanding the essence of the phenomena (Moustakas, 1994). Through this process, barriers to selfdevelopment, the impact of relationships, the international adoptee’s sense of purpose, as well as the resulting complex identity dimensions they perceive, came to light.