Miracle-dz/UniFAR-FTUs huggingface dataset:
MicroRNA profiling in canine multicentric lymphoma

Lymphoma is the most common hematopoietic tumour in dogs and is remarkably similar to the human disease. Tumour biomarker discovery is providing new tools for diagnostics and predicting therapeutic response and clinical outcome. MicroRNAs are small non-coding RNAs that participate in post-transcriptional gene regulation and their aberrant expression can impact genes involved in cancer. The aim of this study was to characterize microRNA expression in lymph nodes and plasma from dogs with multicentric B or T cell lymphoma compared to healthy control dogs. We further compared expression between lymph nodes and corresponding plasma samples and assessed changes in expression at relapse compared to time of diagnosis. Lastly, we investigated microRNAs for association with clinical outcome in patients treated with CHOP chemotherapy. A customized PCR array was utilized to profile 38 canine target microRNAs. Quantification was performed using real time RT-qPCR and relative expression was determined by the delta-delta Ct method. In lymph nodes, there were 16 microRNAs with significantly altered expression for B cell lymphoma and 9 for T cell lymphoma. In plasma, there were 15 microRNAs altered for B cell lymphoma and 3 for T cell lymphoma. The majority of microRNAs did not have correlated expression between lymph node and plasma and only 8 microRNAs were significantly different between diagnosis and relapse. For B cell lymphoma, 8 microRNAs had differential expression in the non-remission group compared to dogs that completed CHOP in complete remission. Four of these microRNAs were also altered in patients that died prior to one-year. Kaplan-Meier survival curves for high versus low microRNA expression revealed that 10 microRNAs were correlated with progression-free survival and 3 with overall survival. This study highlights microRNAs of interest for canine multicentric lymphoma. Future goals include development of microRNA panels that may be useful as biomarkers with the intent to provide improved outcome prediction to veterinary cancer patients.
Computer Mediated Conferencing, E-Mail, Telephone

Abstract Following an introduction to computer mediated conferencing (CMC), the use of CC in nan online orientation for Ph.D. candidates in a dispersed residency institution is described. Although psychology faculty moderate the forum, the librarian plays an active role, by invitation of the chair and faculty of the psychology program. The librarian's interaction with students begins with the CMC forum but e-mail messages, telephone calls, and face-to-face consultation become part of the communication network. Both instructional and social objectives are detailed.
Mid-trimester Genetic Amniocentesis: GATA Experience

OBJECTIVE: To ev aluate the data about amniocenteses those were perf ormed in our department and to compare indications, procedure related losses and pregnancy outcomes. STUDY DESIGN: The study was carried out at the Department of Obstetrics and Gy necology, Faculty of Medicine, Gulhane Military Medical Academy retrospectively. We studied amniocenteses for chromosomal analysis between 2002 and 2004. The data of the patients were obtained from their records. RESULTS: The mean (±SD) gestational age at amniocentesis was 17.9±1.3 weeks (range 16-22 weeks). The most common primary indications for amniocentesis were advanced maternal age (37.0%) and positiv e screening test result (36.5%). In 1452 of the procedures (99.7%), amniotic f luid was obtained by a single puncture. A chromosomal abnormality was detected in 47 women (3.2%) who pref erred termination of pregnancy. The total f etal loss rate was 0 in 1456 (0.0%) within two weeks f ollowing amniocentesis CONCLUSION: Amniocentesis is a saf e and reliable technique with low f etal loss rates in complicated and uncomplicated pregnancies in our study group.
Revisiting Validation Theory: Theoretical Foundations, Applications, and Extensions

Laura I. Rendon (1994) introduced validation theory with particular applicability to lowincome, first-generation students enrolled in higher education. Validation theory was offered as a new way to theorize how these students might find success in college, especially those who found it difficult to get involved, had been invalidated in the past, or had doubts about their ability to succeed. This article gives special attention to: 1) how the theory was developed, including the theoretical foundations of the theory; 2) how the theory has been employed as the foundation to frame studies, discuss student success, improve pedagogy, foster student development, and frame institutional strategies; 3) which theoretical perspectives overlap with validation theory; 4) epistemological and ontological assumptions in validation theory; and 5) future directions that could enhance the theory, as well as advance the future research and practice of validation.
Differentiated approach and indications for optimization of agomelatine therapy for endogenous depression

Objective: to develop and justify differentiated indications for the use of agomelatine (valdoxan) to treat the typological variants of endogenous depressions with varying severity on the basis of an analysis of its therapeutic efficacy.Patients and methods. An open prospective study was conducted using the clinical, psychopathological, and psychometric rating scales: the Hamilton Depression Rating Scale (HAMD-21); Udvalg for Kliniske Undersњgelser Scale (UKU); the Snaith-Hamilton Pleasure Scale (SHAPS) for assessing anhedonic disorders, and statistical methods. Examinations were made in 56 patients (mean age, 34.9 years) with moderate and severe endogenous depression within affective psychosis (n=42) and shift-like schizophrenia (n=14) (ICD-10 items F31.3–4; F32.1–2, and F33.1–2). The patients received a cycle treatment with agomelatine (valdoxan) 25–50 mg once a day in the evening for 4–8 weeks. The patients' status was evaluated over time on fixed days from a reduction in the mean total score (MTS) of the respective scales as insignificant (less than 19% reduction in disorders), moderate (20–49%), good (50–69%), and excellent (70% or more) effects. The effect of agomelatine was analyzed in two patient groups. The specific features of the antidepressive effect and its dynamics in the presence of endogenous depressions of different typologies (melancholic, anxious, and adynamic depressions) were studied in Group 1 (n=26); the effect of agomelatine on anhedonic endogenous depressions and manifestations of anhedonia in different mental activity areas (interests, social activity, emotional engagement and eating/drinking) was investigated in Group 2 (n=30). Results and discussion. There was a good tolerance and a high antidepressant activity of agomelatine during its treatment cycle for moderate and severe endogenous depressions. A significant improvement (an 84.4% reduction in HAMD-21 MTS) was noted in patients at 3 and 4 weeks of the treatment cycle and consistently persisted at a subsequent follow-up. Agomelatine showed a good effect (a 50% or more reduction in HAMD-21 MTS) just at 14 days of therapy. The drug was observed to have a balanced antidepressant effect, significant thymoleptic, stimulant, anxiolytic, and antianhedonic activities (reductions in the MTS of depressive disorders by 90.83, 84.9, 82.39, and 78.9%, respectively). Conclusion. The universal spectrum of the antidepressive effect of agomelatine, its good tolerability, high efficacy, and rapid improvement makes it the drug of choice in treating a wide range of psychopathological endogenous depressions: melancholic, apatho-adynamic, anxious, and anhedonic ones.
Retrograde Placement of Nasointestinal Tubes in Ivor-lewisEsophagectomy

Background: Placing nasointestinal tubes (NITs) is an important procedure during Ivor-Lewis esophagectomy. This study aims to compare two methods of NITs placement in Ivor-Lewis esophagectomy. Methods: A retrospective analysis was performed on 106 patients with middle and lower esophageal carcinoma who has undergone Ivor-Lewis esophagectomy in the First Affiliated Hospital of Nanjing Medical University from January 2016 to April 2017. These cases were divided into two groups: anterograde placement of NITs (n=53) and retrograde placement (n=53). Time-consuming, success rate of the NIT placement, postoperative complications and the effect of nutritional support were compared. Results: All surgery was successfully completed. Compared with antegrade method, retrograde placement of NITs was associated with less time-consuming (14 ± 11 min vs. 5 ± 1 min; P<0.001), higher success rate (88.7% vs. 100%; P=0.027) and smaller effect on circulation system (13.2% vs. 0; P=0.013). There were no differences between two group in serum albumin and prealbumin on postoperative day 1/7 (P>0.05). Incidence rates of postoperative complications and pulmonary infection were no differences between two group (P>0.05). Conclusion: Retrograde placement of NITs is a convenient method with shorter time, higher success rate and less intraoperative complications, which should be popularized during Ivor-Lewis procedure.
A clinico-epidemiological analysis of subclinical hypothyroidism in a tertiary care health center

Background: Subclinical hypothyroidism (SCH) is defined by increase in serum thyroid stimulating hormone (TSH) and free thyroxine (FT4) and free triiodothyronine (FT3) levels within normal range, coupled with absence of typical clinical symptoms. The present study was undertaken to analyse the SCH associated comorbidities, especially lipid disturbances, thyroid autoantibodies, etc.Methods: The present study was retrospective observational study, which was carried out at a tertiary health care center.Results: Out of the 100 patients, majority were in the age group 21 to 30 years (31 patients), followed by 26 patients in age group >51 years and least in age group 41 to 50 years. Prevalence showed female predilection, with female: male ratio of 1.9:1. Most common symptom reported was general fatigue, which was encountered in 40 patients, followed by weight gain, menstrual abnormalities, and constipation. 10 patients were asymptomatic. Serum TSH range in the patients was 5 to 21.1 µIU/l, while mean TSH was 10.9 µIU/l. 20 patients were found to have serum TSH>10.Conclusions: Despite high prevalence, detection rate of subclinical hypothyroidism is very low. Carrying out epidemiological study on national scale is need of the hour, as lack of typical clinical features makes the detection less likely and it has numerous complications, if untreated.
Epidemiology and outcome of burn injuries- A prospective study

Burns are injuries produced by application of dry heat such as flame, radiant heat or some heated solid substance like metal or glass to the body. Local injury to the body by heat may result from dry heat, application of hot bodies, licking by flames resulting in simple burns, moist heat leading to scalds, corrosive poisons resulting in corrosive burns. This was a prospective study carried out at Sri Aurobindo Medical College and Post Graduate Institute, Indore during March 2014 to June 2015 involving all cases admitted in burn ward and post mortem examination done in Department of Forensic Medicine and Toxicology. A total number of 120 cases were taken which included 88 patients who died and a detailed post mortem examination was done. Females outnumbered males as there were 66 (55.0%) females and 54 (45.0%) males. Maximum incidence was in the young adults between the age group of 21-40 years, comprising of 89 (74.17%) cases. Dowry deaths, curse to our so-called modern society are still prevalent, in spite of stringent laws and amendments in the acts. Accidental burn injuries can be reduced by bringing about regulations to develop safer cooking appliances, promoting less inflammable fabrics to be worn at home and educating the community especially women. Keywords: Burn, Autopsy, Inquest, Accidental, Homicidal Burn, Housewives
New Zealand nurses use of humour in surgical nursing practice

ii DEDICATION . iii ACKNOWLEDGEMENTS . iv TABLE OF CONTENTS . vi List of Tables . ix List of Figures . ix CHAPTER ONE: INTRODUCTION . 1 1.1 Nursing practice and humour . 1 1.1.1 Humour within nurse-patient interactions. 2 1.2 Researcher introduction . 4 1.3 Thesis structure . 4 CHAPTER TWO: LITERATURE REVIEW . 6 2.
Evaluation of the Clinical Performance of Nurses Employed in the Neonatal Intensive Care Units

Introduction: Nurses are as the most important health care providers who require extensive knowledge and skills in this field. Despite the high importance of the issue, our knowledge of the current status of clinical performance and levels of nursing skills in the neonatal intensive care units is very low. The present study was done with the aim of determining the status of clinical performance of neonatal nurses in the NICU. Methods: The present research is a descriptive study, through which the clinical performances of 96 neonatal nurses were observed in eight areas. Data collection was done using a researcher-made Scale. The data were analyzed with SPSS version 21. Results: The neonatal nurses’ clinical performances were acceptable (69.74%) in all the areas which includes vital signs control, daily cares, respiratory cares, infants feed, vessels' access, medicine prescription, phototherapy and using required equipment for neonates (such as warmer, Infusion pump, Defibrillator, Incubator, Ventilator and Phototherapy). The highest and lowest practices were assessed in the fields of infant nutrition (84.11%) and equipment utilized (51.93%), respectively. Conclusions: The nursing skills in the study areas seems within an acceptable range, which could be due to the NICU nurses’ interests in this field. In order to improve the performance of nurses in areas where there is a weakness, we suggest considering the importance of these care and disadvantages due to negligence.
Predictors of Urinary Tract Infection and Their Diagnostic Performances among Cameroonian Under-five

ABSTRACT Objective: Urinary tract infection (UTIs) in child is serious public health problem especially in developing countries. This aimed at identifying factors associated with urinary tract infection and determining their diagnosis performances as well as resulting algorithms among Cameroonian under-five. Methods: A descriptive and analytical cross sectional study took place from May 2013 to March 2014 at Pediatrics Department of the Bonassama District hospital in the town of Douala. Urine samples were collected dependent on the age of children and its aptitude to micturate. Ten microliters (10 µL) of urine specimen were cultured at 37°C for 24-48 hours. In addition, sociodemographic, anthropometric, clinic and biological information of each child were documented. Results: The prevalence of UTI was 32.2% (129/400) which was mainly caused by Escherichia coli (41.1%). A total of four risk factors for UTI were found after adjustment for all pertinent characteristics of children. These included female gender (ARR= 0.55; p= 0.0046), presence of fever (ARR = 1.83; p= 0.0426), trouble urine (ARR = 1.36; p= 0.0063) and presence of nitrites in urine (ARR = 1.09; p= 0.0001). Presence of nitrites was the most discriminant parameter based on specificity (98.1%), positive predictive value (95.4%) and negative predictive value (90.1%). The diagnosis performances have gradually improved with the increasing number of parameters. Conclusion: This study reported four factors associated with increased risk for UTI. This also outlined that the presence of nitrites in urine had best diagnosis performances and different predictors-based clinical algorithms could be helpful especially in the identification of UTI-negative children. J Microbiol Infect Dis 2019; 9(2):68-77.
Ad hoc wireless routing schemes based on adaptive modulation in OFDM broadband networks

In order to facilitate communication within an ad hoc wireless network, a routing protocol is required to route data between nodes. The primary goal of such routing protocol is correct and efficient information exchange between the nodes. This paper addresses such routing issue from the Physical Layer perspective of an Orthogonal Frequency Division Multiplexing (OFDM) broadband ad hoc wireless network. Two wireless routing schemes, namely, the Adaptive-All and Adaptive-Select Routing Scheme were proposed, based on the Channel Impulse Response (CIR) of the wireless channel. Extensive simulation results show that both of the schemes are efficient in reducing the error rate and increasing the data throughput.
High Prevalence of Anal and Oral High-Risk Human Papillomavirus in Human Immunodeficiency Virus–Uninfected French Men Who Have Sex With Men and Use Preexposure Prophylaxis

Abstract Background We assessed the prevalence and risk factors of anal and oral high-risk (HR) human papillomavirus (HPV) infection in human immunodeficiency virus–uninfected men who have sex with men (MSM) and take preexposure prophylaxis (PrEP) in France. Methods Anal and oral samples were screened by multiplex real-time polymerase chain reaction (Anyplex II HPV 28; Seegene) for HPV DNA. Results A total of 61 unvaccinated MSM (mean age, 36.1 years) were enrolled. Anal HPV and HR-HPV prevalences were 93.4% and 81.9%, respectively, and oral HPV and HR-HPV prevalences, 33.9% and 19.6%, respectively. HR-HPV type 33 was the most detected genotype, in both anal and oral samples. Among MSM, 68.8% carried ≥1 anal HPV type targeted by the 9-valent Gardasil-9 vaccine; all oral HPV-positive samples carried ≥1 strain included in the vaccine. Condomless receptive anal intercourse and history of anal gonorrhea were the main factors associated with increased risk for anal HPV infection (adjusted odds ratio, 10.4) and anal infection with multiple HR-HPV genotypes (5.77), respectively. Conversely, having had <10 partners in the last 12 months was associated with decreased risk for anal carriage of both multiple HPV (adjusted odds ratio, 0.19) and HR-HPV (0.17) types. Conclusion French MSM using PrEP are at high risk for both anal and oral carriage of HR-HPV that could lead to HPV-related cancers.
The Cancer Burden and Patterns of Erythropoiesis-stimulating Agent Use Among End-stage Renal Disease Patients on Hemodialysis

ANNE MOBLEY BUTLER: The cancer burden and patterns of erythropoiesis-stimulating agent use among end-stage renal disease patients on hemodialysis (Under the direction of M. Alan Brookhart) Patients with end-stage renal disease (ESRD) receiving dialysis have been reported to have increased risk of cancer. Yet, contemporary cancer burden estimates in this population are sparse, and estimates that account for the high competing risk of death in this population are nonexistent. In addition, erythropoiesis-stimulating agents (ESAs) and blood transfusion are commonly used to treat anemia in both ESRD and cancer, however, anemia treatment patterns have not been described among ESRD patients undergoing hemodialysis with concurrent cancer, especially in the recent era of ESA-related safety concerns. Using data from Medicare’s ESRD program, we conducted a retrospective cohort study of hemodialysis patients to describe trends in overall and site-specific cancer incidence rates (1996-2009). We estimated the 5-year cumulative incidence of cancer since dialysis initiation, using competing risk methods. Among hemodialysis patients with incident cancer, we used multivariable generalized linear models to estimate temporal trends in ESA use, epoetin alfa (EPO) dose, transfusion use, and resulting hemoglobin levels (2000-2010). We observed a constant rate of incident cancers for all sites combined, but identified increasing and decreasing rates for some common site-specific cancers. The 5-year cumulative incidence of any cancer was substantially lower in the analysis that did not censor deaths compared to the analysis that censored deaths (9.48% vs. 13.86%). Accounting for case-mix characteristics and the competing risk of death, the 5-year cumulative incidence of any cancer varied by demographic and clinical characteristics. Among hemodialysis patients with incident cancer, ESA use was extremely high and constant whereas transfusion use became increasingly frequent. EPO dose and hemoglobin
Numerical Simulation of Extreme Free Surface Waves

In traditional coastal and offshore engineering design, physical experiments and potential flow solvers are commonly used to investigate wave loading on structures. However, most potential flow models cannot deal with extreme free surface problems including wave breaking or splashing over the structure. Further, physical experiments easily become very complex and scaling issues arise. In these cases, an approach that includes the viscous effects models both water and air and fully couples the wave and structure is needed. This paper deals with the generation of waves close to the breaking point using two commercial software packages. These may be used to generate an extreme design wave to investigate the survivability of offshore wave energy converters or other devices operating in such a challenging environment. Regular and focused wave results are presented and compared with physical experiments and potential flow calculations.
CONCEPTUAL AND PROCEDURAL ABILITIES OF ENGINEERING STUDENTS IN INTEGRATION

The main objective of this study was to examine concept-based instruction of definite integrals and its impact on the conceptualization of integrals in first year engineering students. This study adopted quasi-experimental teaching methods. Research tools included questionnaires and concept-based teaching models. Subjects for this study were 203 first-year engineering students who had just finished studying the concept of differential. Results of this study revealed that students who received concept-based instruction showed higher levels of comprehension, integration, and the ability to apply learned concepts than students who had received procedure-based teaching.
Molecular detection and characterisation of sapoviruses and noroviruses in outpatient children with diarrhoea in Northwest Ethiopia

Abstract Childhood morbidity and mortality of diarrhoeal diseases are high, particularly in low-income countries and noroviruses and sapoviruses are among the most frequent causes worldwide. Their epidemiology and diversity remain not well studied in many African countries. To assess the positivity rate and the diversity of sapoviruses and noroviruses in Northwest Ethiopia, during November 2015 and April 2016, a total of 450 faecal samples were collected from outpatient children aged <5 years who presented with diarrhoea. Samples were screened for noroviruses and sapoviruses by real-time RT-PCR. Partial VP1 genes were sequenced, genotyped and phylogenetically analysed. Norovirus and sapovirus stool positivity rate was 13.3% and 10.0%, respectively. Noroviruses included GII.4 (35%), GII.6 (20%), GII.17 (13.3%), GII.10 (10%), GII.2 (6.7%), GII.16 (5%), GII.7 (3.3%), GII.9, GII.13, GII.20 and GI.3 (1.7% each) strains. For sapoviruses, GI.1, GII.1 (20.0% each), GII.6 (13.3%), GI.2 (8.9%), GII.2 (11.1%), GV.1 (8.9%), GIV.1 (6.7%), GI.3 and GII.4 (2.2% each) genotypes were detected. This study demonstrates a high genetic diversity of noroviruses and sapoviruses in Northwest Ethiopia. The positivity rate in stool samples from young children with diarrhoea was high for both caliciviruses. Continued monitoring is recommended to identify trends in genetic diversity and seasonal variations.