Miracle-dz/UniFAR-FTUs huggingface dataset:
Modeling Growth Response of Broiler Chicken to Feed Consumption Using Linear Data Based Model Structure

2 Abstract: Data on body weight and feed intake were obtained from broiler chickens raised at the University of Benin Farm Project to model growth response of broilers to feed consumption using a linear data based model structure. The birds were given four treatments based on the frequency of change of four commercial feed brands (A, B, C and D). In treatment 1, only feed A was given. Treatment 2 consist of changing all feed brands weekly, changing at interval of every 4 days (treatment 3) and at an interval of every 2 days (treatment 4). Highest growth response was observed in week 7 for combined feeds and week 8 for sole feeding. Peak feed efficiency was also observed a week lower than this ages resulting to predicted body weight of 1874.46g, 1984.54g 2148.55g and 2502.05g for treatments 1, 2, 3 and 4 respectively. Estimated mean relative prediction error (MRPE) were 4.90%, 8.05%, 5.42% and 6.99% were obtained for treatments 1, 2, 3 and 4 respectively. Feed efficiency and cumulative feed consumption showed similar trend over time with peak feed efficiency at week 7 and drastic change in feed consumption starting at week 3. The results of this study indicated similar trend in response thus implying that the growth trajectories for the treatments are nearly the same.
Can Reduced Intake Associated with Downsizing a High Energy Dense Meal Item be Offset by Increased Vegetable Variety in 3–5-year-old Children?

Large portions of energy dense foods promote overconsumption but offering small portions might lead to compensatory intake of other foods. Offering a variety of vegetables could help promote vegetable intake and offset the effect of reducing the portion size (PS) of a high energy dense (HED) food. Therefore, we tested the effect on intake of reducing the PS of a HED unit lunch item while varying the variety of the accompanying low energy dense (LED) vegetables. In a within-subjects design, 43 3–5-year-old pre-schoolers were served a lunch meal in their nursery on 8 occasions. Children were served a standard (100%) or downsized (60%) portion of a HED sandwich with a side of LED vegetables offered as a single (carrot, cherry tomato, cucumber) or variety (all 3 types) item. Reducing the PS of a HED sandwich reduced sandwich (g) (p < 0.001) and total meal intake (kcal) consumption (p = 0.001) without an increased intake of other foods in the meal (LED vegetables (p = 0.169); dessert (p = 0.835)). Offering a variety of vegetables, compared with a single vegetable, increased vegetable intake (g) (p = 0.003) across PS conditions. Downsizing and variety were effective strategies individually for altering pre-schoolers’ intakes of HED and LED meal items, however, using variety to offset HED downsizing was not supported in the present study.
Advances in Prostatic Diagnostics in Dogs: The Role of Canine Prostatic Specific Esterase in the Early Diagnosis of Prostatic Disorders

HIGHLIGHTSCanine Prostatic Specific Esterase (CPSE) is a suitable biomarker to include in a preventive screening for prostate health program in dog.CPSE is the major androgen‐dependent secretory product of canine prostatic gland.Canine CPSE was widely compared to human prostatic specific antigen.Higher CPSE was reported in dogs suffering from several prostatic diseases.CPSE is a very promising non‐invasive tool to early diagnose prostatic diseases in dogs. ABSTRACT In last years, following the increased canine life expectancy and the rising attention pet‐owners devote to their animals, several authors have carried on investigations concerning new techniques to early identify canine prostatic disorders that might affect the dog's quality of life. Prostatic disorders often have an asymptomatic onset and their early diagnosis is difficult: hence, they are usually identified at an advanced stage, only. Traditionally, the diagnosis of prostatic disorders is based on noninvasive tools, such as transrectal and abdominal palpation, seminal or prostatic fluid evaluation, and urinalysis and imaging. On the other hand, a definite diagnosis of prostatic abnormalities could be achieved through prostatic parenchyma Fine Needle Aspiration (FNA) or biopsy. However, these investigations are performed rarely because of their invasiveness. Thus, several authors investigated canine serum biomarkers in order to achieve an earlier diagnostic timing and to apply therapeutic strategies for better outcomes. The Canine Prostatic Specific Esterase (CPSE) has been identified as a suitable biomarker to be included in a prostate health screening program, following the model of prostate‐specific antigen (PSA) in human medicine. A higher CPSE in dogs suffering from several prostatic diseases, such as benign prostatic hyperplasia, bacterial prostatitis, or prostatic carcinoma, was reported in literature. Thanks to the potential usefulness in clinical practice, further studies should investigate the potential role of CPSE in monitoring the medical treatment success in the male reproductive system. Moreover, the spreading availability of serum biomarkers, easily carried out on blood samples in clinical practice, could assure a more accurate evaluation of the actual prevalence of prostatic disorders. The CPSE is actually recognized as a promising diagnostic tool for the detection of prostatic disorders in a "prostate health screening program," in order to properly select those patients requiring further more accurate and expensive diagnostic investigations.
Strategies for reducing treatment default in drug-resistant tuberculosis: systematic review and meta-analysis [Review article].

BACKGROUND Scaling up treatment for multidrug-resistant tuberculosis is a global health priority. However, current treatment regimens are long and associated with side effects, and default rates are consequently high. This systematic review aimed to identify strategies for reducing treatment default. METHODS We conducted a systematic search up to May 2012 to identify studies describing interventions to support patients receiving treatment for multidrug-resistant tuberculosis (MDR-TB). The potential influence of study interventions were explored through subgroup analyses. RESULTS A total of 75 studies provided outcomes for 18 294 patients across 31 countries. Default rates ranged from 0.5% to 56%, with a pooled proportion of 14.8% (95%CI 12.4-17.4). Strategies identified to be associated with lower default rates included the engagement of community health workers as directly observed treatment (DOT) providers, the provision of DOT throughout treatment, smaller cohort sizes and the provision of patient education. CONCLUSION Current interventions to support adherence and retention are poorly described and based on weak evidence. This review was able to identify a number of promising, inexpensive interventions feasible for implementation and scale-up in MDR-TB programmes. The high default rates reported from many programmes underscore the pressing need to further refine and evaluate simple intervention packages to support patients.
Expression of Metallothionein I/II and Ki-67 Antigen in Graves' Disease

Background/Aim: The expression of metallothionein I/II (MT-I/II) was examined in thyroids of Graves' disease (GD) and nodular goiter (NG) patients to determine its role as a potential marker of proliferation and autoimmune inflammation in the thyroid. Patients and Methods: MT-I/II and Ki-67 antigen expression was studied using immunohistochemistry in 72 GD and 24 NG patients. Results: MT-I/II expression was noted in the cytoplasm and nuclei of thyrocytes of GD and NG patients. Cytoplasmic and nuclear MT-I/II expression correlated strongly with GD (r=0.51; p<0.0001) and NG (r=0.50; p=0.0137). Cytoplasmic MT-I/II expression was significantly higher in GD (mean IRS 9.24±2.36) than in NG (mean IRS 7.13±2.51; p=0.0006) and correlated positively with Ki-67 antigen expression (r=0.28; p=0.0165). Nuclear MT-I/II expression was elevated in GD (mean 3.53±0.65) in comparison to NG (mean 2.96±0.86; p=0.028). Conclusion: MT-I/II may be a potential marker of GD in the thyroid and may be potentially involved in thyrocytes' proliferation.
The Development of the Life-worldly Communication Scale for Older Adults in Home Care

In an aging society, health care for older adults has been shifting from facility to home-based care, giving caregivers a larger role in older adult’s everyday life. Therefore, communication plays an important role in creating, maintaining, and developing relationships between older people and caregivers. This study aims to create and verify the Life-worldly Communication Scale (LWCS), to measure the types of communication in older adults in a home care setting. Cronbach’s alpha reliability coefficient was used to confirm the LWCS internal consistency and analyze stability. Validity of LWCS was assessed by principal component analysis, and by correlation with Activities of Daily Living (ADL), dementia, and depression scales. A total of 24 older adults, with an average age of 82.96 years were included. Seven participants suffered from dementia (HDSR ≤ 20), and 4 were Classified with Depression (CESD Score ≥ 16). The status of ADL was: 15 independent, 7 required assistance, and 2 participants needed complete support. LWCS question items had a Cronbach’s alpha of 0.87. The theoretical construct of LWCS was supported by factor analysis. Criterion-related validity was confirmed by a significant correlation between LWCS and actual communication utterance duration by IC recorder. LWCS was found to be useful in assessing the amount of communication between older adults and their caregivers. Frequent communication from caregivers might positively affect mental activity in older adults.
Determination of IL-1B (rs16944) and IL-6 (rs1800796) genetic polymorphisms in IgA nephropathy in a northwest Chinese Han population

IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide, but etiology and pathogenesis continue to be poorly understood. Polymorphisms in the cytokine genes may play a role in the etiology and pathogenesis of IgAN. The incidence of different between diverse ethnic groups suggested important genetic influences on its pathogenesis. We genotype 10 single nucleotide polymorphisms (SNPs) in IL-1B and IL-6 gene using Sequenom Mass-ARRAY technology from 417 IgAN patients and 463 healthy controls of the Chinese Han population. We evaluated these SNPs associated with IgAN utilising the chi-square tests and genetic model analysis. We identified that the minor alleles of rs16944 (“A”), rs1800796 (“G”) in IL-1B, IL-6 were involved in an increasingly risk of IgAN in allelic model analysis, respectively. The rs16944 in IL-1B and rs1800796 in IL-6 were associated with 1.23-fold (95% CI, 1.02-1.48, P = 0.031) and 1.33-fold (95% CI, 1.11-1.66, P = 0.003) increases in the risk of developing IgAN, respectively. There was only rs1800796 still correlated with IgAN in the allelic model after adjustment by age and gender and the Bonferroni correction. In addition, Haplotype Grs1800796A rs2069837G rs2069840 (P = 0.037) and G rs1800796A rs2069837C rs2069840 (P = 0.042) in IL-6were considered to be associated with increased IgAN risk. This study verified the IL-6, IL-1B genetic variants polymorphisms contributed to IgAN susceptibility in a Chinese Han population. Although we identified SNPs susceptibility, however, replication studies and functional research are required to confirm the genetic contribution in IgAN.
Semiparametric estimation for a class of time-inhomogenous diffusion processes

We develop two likelihood-based approaches to semiparametrically estimate a class of time-inhomogeneous diffusion processes: log penalized splines (Psplines) and the local log-linear method. Positive volatility is naturally embedded and this positivity is not guaranteed in most existing diffusion models. We investigate different smoothing parameter selections. Separate bandwidths are used for drift and volatility estimation. In the log P-splines approach, different smoothness for different time varying coefficients is feasible by assigning different penalty parameters. We also provide theorems for both approaches and report statistical inference results. Finally, we present a case study using the weekly three-month Treasury bill data from 1954 to 2004. We find that the log P-splines approach seems to capture the volatility dip in mid-1960s the best. We also present an application to calculate a financial market risk measure called Value at Risk (VaR) using statistical estimates from log P-splines.
Efficacy of dual antiplatelet therapy for preventing recurrence of arterial thrombosis in patients with antiphospholipid syndrome.

OBJECTIVE Warfarin is regarded as the standard treatment for preventing thrombotic events in APS, but the recurrence rate is still high. Dual antiplatelet therapy (DAPT) has been shown to be effective for the prevention of acute coronary syndrome or stroke. The objective of this study was to evaluate the efficacy of DAPT for the prevention of thrombosis recurrence in APS patients with history of arterial thrombosis. METHODS This retrospective cohort study of APS patients was conducted at Hokkaido University Hospital between 1990 and 2016. The secondary prophylactic effects and safety of warfarin monotherapy (Wf), antiplatelet monotherapy (AP), warfarin and antiplatelet combination therapy (Wf + AP) and DAPT were evaluated. The primary endpoints were set as thrombosis-free and adverse events-free survival period. Adverse events were defined as severe bleeding and death. RESULTS A total of 90 APS patients were enrolled. Thrombotic recurrence was found in 40 patients (35 arterial and 5 venous thromboses) and serious adverse events in 20 patients (9 severe bleeding events and 14 deaths). Kaplan-Meier analysis demonstrated a 10-year recurrence-free survival rate of 62%. The recurrence rate per 100 patient-years was as follows: Wf: 11.6, AP: 5.5, Wf: + AP: 3.7, DAPT: 1.8. We demonstrated that DAPT significantly reduced the rate of recurrence compared with Wf (log-rank P = 0.001). There were no significant differences in the rate of serious adverse events among the groups. CONCLUSION DAPT might be considered as an effective and safe option for the prophylaxis of recurrent arterial thrombosis in APS.
Equilibrium Exchange Rate of Asian Currencies: the Chinese Renminbi *

Abstract We estimate the equilibrium exchange rate (EER) of the Chinese renminbi (RMB) vis-a-vis the U.S. dollar from 1992 to 20098. In contrast to the recent empirical studies on the EER employing a large cross-country analysis, we focus on the supply side real factors in estimating the EER by extending the Yoshikawa (1990) model. To better reflect China's processing exports in the context of growing intra-regional trade in Asia, we incorporate in the empirical analysis the source country breakdown data on import prices and input coefficients of intermediate inputs by constructing an annual new International Input-Output (IIO) table for the period from 1992 to 20098. The results show that the EER of Chinese RMB appreciates sharply from 2005 to 20098, suggesting that the current RMB exchange rate has been substantially undervalued and should be revalued by 4665 percent as of 2009 compared tofrom the year 20004 level. Such sharp appreciation of the EER corresponds to the dramatic increase in China's current account surplus from the mid-2000s, especially against the United States, which is ascribed to the significant improvement of both labor and intermediate input coefficients in China.
Valuing Ecosystem Services as Productive Inputs

"This paper explores two methods for valuing ecosystems by valuing the services that they yield to various categories of user and that are not directly valued in the market, and illustrates the usefulness of these methods with an application to the valuation of mangrove ecosystems in Thailand. The first method is known as the production function approach and relies on the fact that ecosystems may be inputs into the production of other goods or services that are themselves marketed, such as fisheries. I discuss issues that arise in measuring the input into fisheries, particularly those due to the fact that the fishery stock is changing over time, and the shadow value of the ecosystem consists in its contribution to the maintenance of the stock as well as its contribution to current output. The second method is known as the expected damage approach and is used to value the services of storm protection in terms of the reduction in expected future storm damage that the ecosystem can provide. These two methods are shown to yield very different valuations of ecosystems from those that would be derived by the methods typically used in cost-benefit analyses. I argue that they represent a significant improvement on current practice. " Copyright (c) CEPR, CES, MSH, 2007.
Why are there so many mimicry rings? Correlations between habitat, behaviour and mimicry in Heliconius butterflies

Abstract In the new world tropics there is an extravagant array of sympatric butterfly mimicry rings. This is puzzling under strictly coevolutionary (Mullerian) mimicry: all unpalatable species should converge as ‘co-mimics’ to the same pattern. If mimicry has usually evolved in unpalatable species by one-sided (Batesian) evolution, however, it is easy to see that mimicry rings centred on different models could remain distinct. If mimicry rings were also segregated by habitat, a diversity of mimicry rings could be stabilized. In this paper we report correlations between behaviour and mimicry of nine unpalatable Heliconius species. It is already known that co-mimics fly in similar habitats, and non-mimics fly in different habitats, although there is much overlap. Contrary to a previous report, we find little difference in flight heights of heliconiine mimicry rings; all species fly from ground level to the canopy. However, co-mimics roost at night in similar habitats and at similar heights above the ground, but in different habitats and at different heights from species in other mimicry rings. Heliconius (especially the erato taxonomic group) are renowned for roosting gregariously; and co-mimics roost gregariously with each other more often than with non-mimics. Gregarious roosting is therefore common between species, as well as within species. There are thus strong links between mimicry and behavioural ecology in Heliconius. The paradoxical correlation between nocturnal roosting and visual mimicry is presumably explained by bird predation at dusk when roosts are forming, or at dawn before they have disbanded. Direct evidence of predation is lacking, but there are high rates of disturbance by birds at these times. These results, together with knowledge of the phylogeny of Heliconius, suggest that species from the melpomene -group of Heliconius have radiated to occupy mimetic niches protected by model species in the Ithomiinae and the erato -group of Heliconius. A variety of sympatric mimicry rings is apparently maintained because key models fail to converge, while more rapidly-evolving unpalatable mimics evolve towards the colour patterns of the models. The maintenance of mimetic diversity would be aided by the habitat and behavioural differences between mimicry rings revealed here, provided that different predators are found in different habitats. This explanation for the maintenance of multiple mimicry rings is more plausible for Heliconius mimicry than alternatives based on visual mating constraints, thermal ecology, or camouflage.
Belief in memories may be relinquished as often for adulthood as for childhood events, but for different reasons

ABSTRACT The age distribution of nonbelieved memories (NBMs) reported by young and older adults typically reflects a large proportion of events dated to childhood. The present study aimed to further investigate the age of origin of NBMs by using instructions that include an NBM related to adulthood. Participants aged from 40 to 80 years were asked to describe an NBM, to explain why they had stopped believing their memory, and to rate its phenomenal characteristics. Participants also described and rated an age-matched believed memory (BM). The results revealed a similar proportion of nonbelieved events experienced in childhood and adulthood, thus calling into question the hypothesis that NBMs are mainly related to childhood events. We also found that NBMs might emerge for different reasons depending on the time of events. Additional analyses indicated that, overall, the influence of temporal distance on the ratings of phenomenal characteristics was similar for BMs and NBMs.
Long‐range projections from sparse populations of GABAergic neurons in murine subplate

The murine subplate contains some of the earliest generated populations of neurons in the cerebral cortex, which play an important role in the maturation of cortical inhibition. Here we present multiple lines of evidence, that the subplate itself is only very sparsely populated with GABAergic neurons at postnatal day (P)8. We used three different transgenic mouse lines, each of which labels a subset of GABAergic, ganglionic eminence derived neurons. Dlx5/6‐eGFP labels the most neurons in cortex (on average 11% of NEUN+ cells across all layers at P8) whereas CGE‐derived Lhx6‐Cre::Dlx1‐Venusfl cells are the sparsest (2% of NEUN+ cells across all layers at P8). There is significant variability in the layer distribution of labeled interneurons, with Dlx5/6‐eGFP and Lhx6‐Cre::R26R‐YFP being expressed most abundantly in Layer 5, whereas CGE‐derived Lhx6‐Cre::Dlx1‐Venusfl cells are least abundant in that layer. All three lines label at most 3% of NEUN+ neurons in the subplate, in contrast to L5, in which up to 30% of neurons are GFP+ in Dlx5/6‐eGFP. We assessed all three GABAergic populations for expression of the subplate neuron marker connective tissue growth factor (CTGF). CTGF labels up to two‐thirds of NEUN+ cells in the subplate, but was never found to colocalize with labeled GABAergic neurons in any of the three transgenic strains. Despite the GABAergic neuronal population in the subplate being sparse, long‐distance axonal connection tracing with carbocyanine dyes revealed that some Gad65‐GFP+ subplate cells form long‐range axonal projections to the internal capsule or callosum.