Miracle-dz/UniFAR-FTUs huggingface dataset:
Increasing multilingualism in schoolscapes

In this qualitative research study, we examine changes made in 23 New York City schools that participated in a project for which participating schools were asked to regard bilingualism as a resource in instruction and develop a multilingual linguistic landscape. Findings document efforts made by schools to change their linguistic landscape in ways that recognize students’ many languages and cultures, significant corresponding ideological shifts by school leaders from monolingual to multilingual views of language and language learning, educators’ incorporation of students’ home languages in instruction, and new formal language education policies resulting from these efforts. We document the impact of all of these changes on students and their families and suggest that research on linguistic landscape conducted in schools should consider not only the physical landscape but also its connections to pedagogy, programming, and language policies.
Evidence for a role of virulent human immunodeficiency virus (HIV) variants in the pathogenesis of acquired immunodeficiency syndrome: studies on sequential HIV isolates

Sequential human immunodeficiency virus (HIV) isolates, recovered from a panel of longitudinally collected peripheral blood mononuclear cells obtained from 20 initially asymptomatic HIV-seropositive homosexual men, were studied for differences in replication rate, syncytium-inducing capacity, and host range. Eleven individuals remained asymptomatic; nine progressed to acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC) at the time point at which the last HIV isolate was obtained. In 16 individuals, only non-syncytium-inducing (NSI) isolates, with a host range restricted to mononuclear cells, were observed. From four individuals, high-replicating, syncytium-inducing (SI) isolates that could be transmitted to the H9, RC2A, and U937 cell lines were recovered. From two of these four individuals, SI isolates were obtained throughout the observation period. In the two others, a transition from NSI to SI HIV isolates was observed during the period of study. Three of these four individuals developed ARC or AIDS 9 to 15 months after the first isolation of an SI isolate. With the exception of the two individuals in whom a transition from NSI to SI isolates was observed, within a given individual the replication rate of sequential HIV isolates was constant. A significant correlation was found between the mean replication rate of isolates obtained from an individual and the rate of CD4+ cell decrease observed in this individual. In individuals with low-replicating HIV isolates, no significant CD4+ cell loss was observed. In contrast, recovery of high-replicating isolates, in particular when these were SI isolates, was associated with rapid decline of CD4+ cell numbers and development of ARC or AIDS. These findings indicate that variability in the biological properties of HIV isolates is one of the factors influencing the course of HIV infection.
Decolonizing the Way Libraries Organize

Knowledge organization systems (KOSs) are social constructs that represent the needs and knowledge of specific communities at specific times and places (Olsen, 1998; Svenonius, 2000; Hunter, 2009). Libraries use knowledge organization systems like cataloging codes, classification schemes, and languages of aboutness to describe the information objects they hold. These structures are central to library cataloging (Farnel, 2017). Because library KOSs reflect the biases of the time periods and places they were created, applications of these systems outside of those contexts are potentially problematic in terms of gender, culture, and ethnic exclusion (Olsen, 1998; Alemu & Stevens, 2015). Many of the systems used in libraries throughout the world originated in the United States or Europe. It is time to consider the impact that these systems have outside of their designated contexts and how to integrate other perspectives. The purpose of this paper is to question the cultural suitability of the systems and procedures libraries have in place to organize materials. As stated by Berman, the systems and approaches that catalogers adhere to are “so slavish” (Berman & Gross, 2017). When librarians talk about changes to codes and standards that are currently in use, it is often at the micro-level. These micro-level changes include submitting a term addition or term change request to the Library of Congress Subject Headings; or adding/revising a rule to Resource Description and Access. What may be needed are not these micro-level changes, but changes at the macro-level. Librarians need to feel empowered to go beyond the Euro-American models of library cataloging work, without feeling that they are violating the integrity of their relationships with networks and consortia. Structures need to be in place to allow libraries and catalogers to vary the way they apply the necessary guidelines. Specific examples—with an emphasis on Southeast Asia -- is presented to argue these points.
Randomized phase II window trial of two schedules of irinotecan with vincristine in patients with first relapse or progression of rhabdomyosarcoma: a report from the Children's Oncology Group.

PURPOSE To compare response rates for two schedules of irinotecan with vincristine in patients with rhabdomyosarcoma at first relapse or disease progression. PATIENTS AND METHODS Patients with first relapse or progression of rhabdomyosarcoma and an unfavorable prognosis were randomly assigned to one of two treatment schedules of irinotecan with vincristine: regimen 1A included irinotecan 20 mg/m(2)/d intravenously for 5 days at weeks 1, 2, 4, and 5 with vincristine 1.5 mg/m(2) administered intravenously on day 1 of weeks 1, 2, 4, and 5; regimen 1B included irinotecan 50 mg/m(2)/d intravenously for 5 days at weeks 1 and 4 with vincristine as in regimen 1A. Disease response was assessed at week 6. Those with responsive disease continued to receive 44 weeks of multiagent chemotherapy that incorporated the assigned irinotecan-vincristine regimen. RESULTS Ninety-two eligible patients were randomly assigned (1A, 45; 1B, 47). Response could be assessed in 89 patients (1A, 42; 1B, 47). There were five complete responses and six partial responses on regimen 1A (response rate, 26%; 95% CI, 16% to 42%) and 17 partial responses on regimen 1B (response rate, 37%; 95% CI, 25% to 51%; P = .36). Neutropenia was less common on regimen 1A (P = .04). One-year failure-free and overall survival rates for regimen 1A were 37% (95% CI, 23% to 51%) and 55% (95% CI, 39% to 69%), respectively, and for 1B, they were 38% (95% CI, 25% to 53%) and 60% (95% CI, 44% to 72%). CONCLUSION There was no difference in the response rates between the two irinotecan-vincristine schedules. We recommend the shorter, more convenient regimen (1B) for further investigation.
Similar Time Course Changes in Striatal Levels of Glutamic Acid Decarboxylase and Proenkephalin mRNA Following Dopaminergic Deafferentation in the Rat

Abstract: The time course changes in levels of mRNA encoding glutamic acid decarboxylase (GAD) and proenkephalin (PPE) was analyzed in the rat striatum following unilateral lesion of substantia nigra with 6‐hydroxydopamine. The levels of both GAD and PPE mRNAs increased after the dopaminergic deafferentation, reaching concomitantly a maximal twofold increase on day 25. Thereafter, the mRNA levels declined; at 4 months, the amount of PPE mRNA remained slightly elevated whereas GAD mRNA had returned to the control value, suggesting the action of a compensatory mechanism. We also observed a rise of glial fi‐brillary acidic protein mRNA level which reflects a reactive astrocytosis. In contrast, α‐tubulin mRNA level remained unchanged, indicating that no significant synaptogenesis occurs in this experimental situation. No obvious modification in mRNA levels was detected in the striatum contralateral to the lesion. These results highlight the role of the modulation of gene expression in adaptive processes to dopamine deficiency in striatal efferent pathways. Its relevance to the pathophysiology of Parkinson's disease is discussed.
Integrating phylogeography and paleoecology to investigate the origin and dynamics of hybrid zones: insights from two widespread North American firs

Secondary contact between closely related taxa routinely occurs during postglacial migrations. After initial contact, the location of hybrid zones may shift geographically or remain spatially stable over time in response to various selective pressures or neutral processes. Studying the extent and direction of introgression using markers having contrasted levels of gene flow can help unravel the historical dynamics of hybrid zones. Thanks to their contrasted maternal and paternal inheritance, resulting in different levels of gene flow for mitochondrial and chloroplast DNA (mtDNA and cpDNA), the Pinaceae stand out as a relevant biological model for this purpose. The objective of the study was to assess whether the hybrid zone between Abies balsamea and Abies lasiocarpa (two largely distributed Pinaceae) has moved or remained stable over time by analysing the distribution of cytoplasmic DNA variation as well as published palaeobotanical data. Interspecific gene flow was higher for cpDNA than mtDNA markers; hence, the geographic distribution of mitotypes was more congruent with species distributions than chlorotypes. This genetic signature was contrary to expectations under a moving hybrid zone scenario, as well as empirical observations in other conifers. Genetic evidence for this rare instance of stable hybrid zone was corroborated by the colonization chronology derived from published fossil data, indicating that the two fir species initially came into contact in the area corresponding to the current sympatric zone 11 kyr ago. While an explanatory analysis suggested the putative influence of various environmental factors on the relative abundance of cytoplasmic genome combinations, further research appears necessary to assess the role of both demographic history and selective factors in driving the dynamics of hybrid zones.
The Theory of the Labor‐Managed Firm: Past, Present, and Future

The economic theory of the labor-managed firm dates back 60 years. Here I review the intellectual history of this field, with critical remarks and proposals for future development. The decades of the 1960sâ€“1980s saw a burst of theoretical speculation that generally did not hold up well under empirical scrutiny. By the 1990s, progress on the mainstream theory of the firm was overtaking some of this early research. At the same time, a growing body of econometric work on labor-managed firms was providing new stylized facts for theorists to explain. While the earlier period was characterized by an excess supply of theories relative to facts, more recently the balance has begun to tip in the opposite direction. I close by suggesting new theoretical directions that might shed light on the empirical asymmetries between capital-managed and labor-managed firms.
Acute exercise and skeletal muscle antioxidant and metabolic enzymes: effects of fiber type and age.

Inhibition of metabolic enzyme activity has been associated with free radical stress in locomotor muscle with prolonged or intense exercise. However, it is not known whether such alterations with acute exercise in skeletal muscle are influenced by muscle fiber type or age. Twenty 4-mo-old and twenty 24-mo-old female Fischer-344 rats were divided at random into young exercised (YE; n = 10), old exercised (OE; n = 10), young control (YC; n = 10), and old control (OC; n = 10) groups. Animals in both YE and OE groups ran on a treadmill (10% uphill grade) for 40 min at approximately 75% of each age-group's maximal O2 consumption. Immediately after the treadmill run, white gastrocnemius (WG), red gastrocnemius (RG), and soleus (SOL) muscles were removed and quick-frozen in liquid nitrogen. Malondialdehyde was significantly increased (P < 0.05) in RG of YE vs. YC rats. Glutathione peroxidase activity was significantly elevated (P < 0.05) in the WG of YE rats. Analysis of variance revealed a significant over-all increase in superoxide dismutase activity with exercise. Activities of phosphofructokinase (PFK), citrate synthase, succinate dehydrogenase, and 3-hydroxyacyl-CoA dehydrogenase were unchanged (P > 0.05) with acute exercise in the SOL. However, PFK activity was decreased in the WG by 60% in OE but only 33% in YE, and in the RG by 41% in OE but only 21% in YE. We conclude that maximal glycolytic flux in the gastrocnemius may be adversely affected by acute exercise, and this effect was more pronounced in the 24-mo-old group.
Effect Of Chronic Lithium Administration On Endothelium‐Dependent Relaxation In Rat Aorta

1. The effects of chronic lithium administration on the relaxant responses of rat thoracic aortic rings in the presence of indomethacin (a cyclo‐oxygenase inhibitor) and/or NG‐nitro‐L‐arginine (L‐NOARG; a nitric oxide synthase inhibitor) to acetylcholine (ACh) or sodium nitroprusside were investigated in the present study.
State Collective Bargaining Laws and Public-Sector Pay

Using the Public Use Microdata Sample from the 2005 to 2015 American Community Survey, the authors provide new evidence on how state collective bargaining laws affect public-sector wages. To isolate the causal effect of bargaining laws on public-sector pay, they examine wage differentials between otherwise similar public- and private-sector employees located in the same local labor market. They estimate difference-in-differences (DD) models that exploit two sources of plausibly exogenous variation: 1) policy discontinuities along state borders and 2) variation within states in collective bargaining laws in states where the majority of public workers are without collective bargaining rights. Findings show that mandatory collective bargaining laws increase public-sector wages by approximately 5 to 8 percentage points. Results therefore suggest that mandatory collective bargaining laws provide a formal mechanism through which public-sector workers are able to bargain for increased compensation.
Study of the comparative activity of piperacillin/tazobactam with currently available antibiotics against 8206 aerobic isolates.

OBJECTIVES To compare the activity of piperacillin-tazobactam with piperacillin and other parenterally administered antibiotics against aerobic Gram-negative bacilli and Gram-positive cocci isolated from across Canada, and to determine the prevalence of resistance mediated by extended-spectrum cephalosporinases. METHODS Sixty-one laboratories participated. Disk diffusion testing was performed in accordance with methods outlined by the National Committee for Clinical Laboratory Standards. Susceptibilities were performed on 8206 strains. Escherichia coli and Klebsiella pneumoniae with reduced susceptibilities to third-generation cephalosporins were screened for extended-spectrum beta-lactamases (ESBLs). RESULTS Piperacillin-tazobactam was active against 92% of the strains, piperacillin against 81% and ticarcillin-clavulanic acid against 88%. Few differences were observed in the relative susceptibility of strains from teaching or community hospitals, from different anatomic sites or from different regions of the country. Aerobic Gram-negative bacilli tested tended to be more susceptible to all the agents than was recently reported in a similar American study. Only 43% of Enterococcus faecium were susceptible to ampicillin and 42% to piperacillin piperacillin with and without tazobactam. Only two enterococcal strains were resistant to vancomycin, and 19 had intermediate zone sizes. Of the 10 strains of E coli and eight strains of K pneumoniae with reduced susceptibility to extended spectrum cephalosporins, only one demonstrated typical ESBL activity. CONCLUSIONS Canadian aerobic Gram-positive cocci and Gram-negative bacilli remain highly susceptible to many currently available antibiotics. The findings confirm a broad spectrum of activity of piperacillin-tazobactam and indicate that the pattern of susceptibility is quite uniform from different body sites, in both teaching and community hospitals, and across the country.
Assessing Plasma Total Homocysteine in Patients with End-Stage Renal Disease

Elevated plasma total homocysteine (tHcy) is a risk factor for cardiovascular disease; however, in light of several recent randomized trials, the issue of causality has been cast into doubt. Patients with end-stage renal disease are particularly interesting as they consistently have elevated tHcy and their leading causes of morbidity and mortality are related to cardiovascular disease. In the present article, we review the early evidence for the homocysteine theory of atherosclerosis, homocysteine metabolism, mechanisms of toxicity, and pertinent available clinical investigations. Where appropriate, the sparse evidence of homocysteine in peritoneal dialysis is reviewed. We conclude by addressing the difficulties associated with lowering plasma tHcy in patients with end-stage renal disease and suggest some novel methods for lowering tHcy in this resistant population. Finally, to address the issue of causality, we recommend that clinicians and scientists await the results of the FAVORIT trial before abandoning homocysteine as a modifiable risk factor for cardiovascular disease, as this study has recruited patients from a population with consistently elevated plasma tHcy who are known to respond to vitamin therapy.
A collaborative approach to the treatment alliance in bipolar disorder.

OBJECTIVES The treatment alliance is the arena in which psychopharmacological and other therapeutic interventions occur. The nature and quality of the treatment alliance may affect adherence to treatment and the realization of the benefits of effective pharmacological treatment in clinical practice. It is an area that has attracted little systematic study, despite the available evidence suggesting that it plays a measurable role in clinical outcomes. METHODS A literature search was undertaken using Medline, Ovid, Psychinfo and Science Direct from 1975 to 2004. The following key words were used: bipolar disorder, patient adherence, non-adherence to medication, compliance, doctor-patient relationship, doctor-patient communication, treatment alliance, therapeutic alliance, chronic illness management, collaborative care, self-management, health beliefs, self-efficacy, self-determination, autonomy support, motivational interviewing. RESULTS Psychosocial interventions have demonstrated positive effects on adherence problems. Studies of the impact of the treatment alliance on outcomes in mental illness highlight the possibilities of fruitful research in this area in bipolar disorder. Different theoretical models of changing health related behaviour may inform approaches to the treatment alliance. CONCLUSIONS Results suggest the usefulness of a collaborative approach to the treatment alliance. Attention needs to be given to developing intervention models that target modifiable risk factors for non-adherence and address patient, clinician and illness related variables to enhance medication adherence in the treatment alliance. Refinement of these models through controlled evaluation in real world settings may lead to integration in health care delivery systems.
Integrating a Hybrid Back Propagation Neural Network and Particle Swarm Optimization for Estimating Soil Heavy Metal Contents Using Hyperspectral Data

Soil heavy metals affect human life and the environment, and thus, it is very necessary to monitor their contents. Substantial research has been conducted to estimate and map soil heavy metals in large areas using hyperspectral data and machine learning methods (such as neural network), however, lower estimation accuracy is often obtained. In order to improve the estimation accuracy, in this study, a back propagation neural network (BPNN) was combined with the particle swarm optimization (PSO), which led to an integrated PSO-BPNN method used to estimate the contents of soil heavy metals: Cd, Hg, and As. This study was conducted in Guangdong, China, based on the soil heavy metal contents and hyperspectral data collected from 90 soil samples. The prediction accuracies from BPNN and PSO-BPNN were compared using field observations. The results showed that, 1) the sample averages of Cd, Hg, and As were 0.174 mg/kg, 0.132 mg/kg, and 9.761 mg/kg, respectively, with the corresponding maximum values of 0.570 mg/kg, 0.310 mg/kg, and 68.600 mg/kg being higher than the environment baseline values; 2) the transformed and combined spectral variables had higher correlations with the contents of the soil heavy metals than the original spectral data; 3) PSO-BPNN significantly improved the estimation accuracy of the soil heavy metal contents, with the decrease in the mean relative error (MRE) and relative root mean square error (RRMSE) by 68% to 71%, and 64% to 67%, respectively. This indicated that the PSO-BPNN provided great potential to estimate the soil heavy metal contents; and 4) with the PSO-BPNN, the Cd content could also be mapped using HuanJing-1A Hyperspectral Imager (HSI) data with a RRMSE value of 36%, implying that the PSO-BPNN method could be utilized to map the heavy metal content in soil, using both field spectral data and hyperspectral imagery for the large area.
Nonlinear elimination and hepatic concentration of conjugation‐ metabolite of valproate in guinea‐pigs

The plasma clearance and metabolic rate characteristics of valproic acid (VPA) were studied using guinea‐pigs placed on various (0.08‐9 μmol ml−1 = 11–1303 μg ml−1) steady‐state plasma concentrations (Css) by constant intravenous (i.v.) infusion. The total clearance (CL) was significantly decreased at plasma concentration of 0.61 μmol ml−1 (88 μg ml−1). The metabolic clearance of VPA was apparently biphasic. The maximum metabolic rate (Vmax) and the Michaelis‐Menten constant (Km) for the primary (Vmaxl, Kml) and the secondary (Vmax2, Km2) pathways were Vmaxl = 1.52 μmol min −1kg−1, Kml = 0.15 μmol ml−1, Vmax2 = 24.98 μmol min −1 kg−1 and Km2 = 11.70 μmol ml−1, respectively. The Kml value was within clinical therapeutic concentration range. The formation of conjugated VPA (cjVPA) metabolite in liver was shown to be saturable. Plasma protein binding of VPA was also nonlinear. The dose‐dependent decrease in metabolic clearance was counterbalanced by the increased unbound fraction (fu), resulting in a relatively constant apparent clearance of VPA over a wide concentration range. The hepatic concentration of VPA was not significantly different from the plasma unbound concentration, again over a wide concentration range. The biliary and hepatic concentrations of VPA were not significantly different; but the concentration ratio of cjVPA in bile compared with that of VPA in liver decreased against hepatic concentration of VPA, which suggests a saturable conjugation rate. The Km value estimated from hepatic cjVPA production as a function of plasma VPA concentration was comparable with the Kml value. These results implied that the primary metabolic parameters may describe the conjugation pathway which is nonlinear within the clinical therapeutic concentration range.