Miracle-dz/UniFAR-FTUs huggingface dataset:
C-reactive protein, procalcitonin, interleukin-6, vascular endothelial growth factor and oxidative metabolites in diagnosis of infection and staging in patients with gastric cancer.

AIM The current study was to determine the serum/plasma levels of VEGF, IL-6, malondialdehyde (MDA), nitric oxide (NO), PCT and CRP in gastric carcinoma and correlation with the stages of the disease and accompanying infection. METHODS We examined the levels of serum VEGF, IL-6, PCT, CRP and plasma MDA, NO in 42 preoperative gastric cancer patients and 23 healthy subjects. There were infection anamneses that had no definite origin in 19 cancer patients. RESULTS The VEGF levels (mean+/-SD; pg/mL) were 478.05+/-178.29 and 473.85+/-131.24 in gastric cancer patients with and without infection, respectively, and these values were not significantly different (P>0.05). The levels of VEGF, CRP, PCT, IL-6, MDA and NO in cancer patients were significantly higher than those in healthy controls and the levels of CRP, PCT, IL-6, MDA and NO were statistically increased in infection group when compared with non-infection group (P<0.001). CONCLUSION Although serum VEGF concentrations were increased in gastric cancer, this increase might not be related to infection. CRP, PCT, IL-6, MDA and NO have obvious drawbacks in the diagnosis of infections in cancer patients. These markers may not help to identify infections in the primary evaluation of cancer patients and hence to avoid unnecessary antibiotic treatments as well as hospitalization. According to the results of this study, IL-6, MDA, NO and especially VEGF can be used as useful parameters to diagnose and grade gastric cancer.
Effect of a change in selection year on success in male soccer players

Since 1997 and following the guidelines of the International Football Association, the Belgian Soccer Federation has used January 1st as the start of the selection year. Previously, August 1 was the start. This shift prompted an investigation of changes in birth‐date distributions throughout youth categories for 1996–1997 compared to the 1997–1998 competitive years. Birth dates were considered for national youth league players, ages 10–12, 12–14, 14–16, and 16–18 years. Kolmogorov Smirnov tests assessed differences between observed and expected birth‐date distributions. Regression analyses examined the relationship between month of birth and number of participants both before and after the August to January shift. Results indicated that from 1996 to 1997, youth players born from January to March (the early part of the new selection year) were more likely to be identified as “talented” and to be exposed to higher levels of coaching. In comparison, players born late in the new selection year (August to October) were assessed as “talented” in significantly lower proportions. Specific suggestions are presented to reduce the relative age effect. Am. J. Hum. Biol. 12:729–735, 2000. © 2000 Wiley‐Liss, Inc.
Predicting hydrophobic solvation by molecular simulation: 1. Testing united‐atom alkane models

We present a systematic test of the performance of three popular united‐atom force fields—OPLS‐UA, GROMOS and TraPPE—at predicting hydrophobic solvation, more precisely at describing the solvation of alkanes in alkanes. Gibbs free energies of solvation were calculated for 52 solute/solvent pairs from Molecular Dynamics simulations and thermodynamic integration making use of the IBERCIVIS volunteer computing platform. Our results show that all force fields yield good predictions when both solute and solvent are small linear or branched alkanes (up to pentane). However, as the size of the alkanes increases, all models tend to increasingly deviate from experimental data in a systematic fashion. Furthermore, our results confirm that specific interaction parameters for cyclic alkanes in the united‐atom representation are required to account for the additional excluded volume within the ring. Overall, the TraPPE model performs best for all alkanes, but systematically underpredicts the magnitude of solvation free energies by about 6% (RMSD of 1.2 kJ/mol). Conversely, both GROMOS and OPLS‐UA systematically overpredict solvation free energies (by ∼13% and 15%, respectively). The systematic trends suggest that all models can be improved by a slight adjustment of their Lennard‐Jones parameters. © 2016 Wiley Periodicals, Inc.
Control of insulin granule dynamics by AMPK dependent KLC1 phosphorylation

The movement of insulin granules along microtubules, driven by kinesin-1/Kif5B, is essential for glucose-stimulated insulin secretion from pancreatic β-cells. 5΄AMP-activated protein kinase (AMPK) is a heterotrimeric serine/threonine kinase, which is activated in β-cells at low glucose concentrations, but inhibited as glucose levels increase. AMPK activation blocks glucose-stimulated recruitment of secretory granules to the cell surface and insulin secretion, suggesting motor proteins may be targets for this kinase. Whilst both kinesin-1/Kif5B and kinesin light chain-1 (KLC1) contain consensus AMPK phosphorylation sites only a peptide corresponding to Ser520 in mouse KLC1 and purified recombinant GST-KLC1 were phosphorylated by purified AMPK in vitro. To test the hypothesis that phosphorylation at this site may modulate kinesin-1-mediated granule movement, we developed a novel approach to study the dynamics of the granules within a cell in three-dimensions using Nokigawa spinning disc confocal microscopy. This cell-wide approach revealed that the number of longer excursions (>10 µm) increased significantly in response to elevated glucose concentration (30 vs 3 mM) in control MIN6 cells. However, similar changes were seen in cells over-expressing wild-type KLC1, phosphomimetic (S517/520D) or non-phosphorylatable (S517/520A) mutants of KLC1. Moreover, no evidence for a change in the phosphorylation state of KLC1 at Ser520 after AMPK activation was obtained using an anti-phospho Ser520-specific antibody. Thus, changes in the phosphorylation state of KLC1 at Ser517/520 are unlikely to affect motor function. In conclusion, we describe a new three-dimensional cell wide approach for the analysis of secretory granule dynamics in living β-cells.
l-Arginine Consumption by Macrophages Modulates the Expression of CD3ζ Chain in T Lymphocytes1

l-Arginine plays a central role in the normal function of several organs including the immune system. It is metabolized in macrophages by inducible nitric oxide synthase to produce nitric oxide, important in the cytotoxic mechanisms, and by arginase I (ASE I) and arginase II (ASE II) to synthesize l-ornithine and urea, the first being the precursor for the production of polyamines needed for cell proliferation. l-Arginine availability can modulate T cell function. Human T cells stimulated and cultured in the absence of l-arginine lose the expression of the TCR ζ-chain (CD3ζ) and have an impaired proliferation and a decreased cytokine production. The aim of this work was to test whether activated macrophages could modulate extracellular levels of l-arginine and alter T cell function, and to determine which metabolic pathway was responsible for this event. The results show that macrophages stimulated with IL-4 + IL-13 up-regulate ASE I and cationic amino acid transporter 2B, causing a rapid reduction of extracellular levels of l-arginine and inducing decreased expression of CD3ζ and diminished proliferation in normal T lymphocytes. Competitive inhibitors of ASE I or the addition of excess l-arginine lead to the re-expression of CD3ζ and recovery of T cell proliferation. In contrast, inducible nitric oxide synthase or ASE II failed to significantly reduce the extracellular levels of l-arginine and modulate CD3ζ expression. These results may provide new insights into the mechanisms leading to T cell dysfunction and the down-regulation of CD3ζ in cancer and chronic infectious diseases.
A Discovery of Multiple Levels of Open Innovation in Understanding the Economic Sustainability. A Case Study in the Manufacturing Industry

The aim of this paper is twofold: firstly, investigate the theory of governance and open innovation by adding the process of value creation and value capture; secondly, to discuss the potential link between open innovation and economic sustainability. With the current emphasis of the literature being on either the value creation or value capture processes, the phenomenon of open innovation is only partially understood. To help broaden this understanding, we conducted an in-depth case study of the processes behind the transformation of governance structures at Iran Khodro Company (IKCO), which led to the emergence of both value creation and capture processes. A multi project analysis (from 1994 to 2012) has point out that IKCO have created and developed a formal value creation and capture processes from the part level through to the architectural level, allowing a gradual openness at those levels and at the same time ensuring a greater economic sustainability of the IKCO business. These findings reveal the existence of four unique levels of open innovation in product development architecture. Practical implications are also provided relating the impact that each of these levels can have on the economic sustainable model of the firms in the manufacturing sector.
Serum Adiponectin and Leptin Concentrations in Patients With Chronic Pancreatitis of Alcoholic and Nonalcoholic Origin

Objective: The aim of this study was to assess serum adiponectin and leptin concentrations in patients with chronic pancreatitis of alcoholic and nonalcoholic origin. Methods: Forty-four male patients with chronic pancreatitis of alcoholic origin and 10 patients of nonalcoholic origin as well 16 healthy subjects were examined. Fasting blood samples were collected. Serum adiponectin, leptin, and insulin concentrations were determined by radioimmunoassay methods. Results: Patients with chronic pancreatitis had lower body mass index values compared with those of control. Nonetheless, there were no differences in serum adiponectin concentration between pancreatitis patients and healthy controls. Pancreatitis patients had lower serum leptin and insulin concentrations than healthy subjects. No difference in serum leptin and insulin concentrations between patients with chronic pancreatitis of alcoholic and nonalcoholic origin was observed. The serum adiponectin/leptin concentration ratio was higher in chronic pancreatitis patients than in control subjects. Conclusions: Chronic pancreatitis in humans (a) is associated with the decrease in serum leptin and insulin concentrations, (b) does not affect serum adiponectin concentration but increases serum adiponectin/leptin concentration ratio, and (c) alters the interrelationship between serum adiponectin and insulin concentrations. Moreover, these results suggest that changes in serum leptin and insulin concentrations are independent on the etiology of chronic pancreatitis.
Creation and Validation of the Critical Thinking about Sustainability Scale

Alexander, Vivian G. Ph.D., Purdue University, December 2015. Creation and Validation of the Critical Thinking about Sustainability Scale. Major Professor: Yukiko Maeda. Critical thinking and Sustainability are both key topics of interest to higher education institutions. Over the decades, researchers have sought to measure undergraduate students’ critical thinking ability as well as their understanding of sustainability. However, while researchers acknowledge the importance of critical thinking to approaching the subject of sustainability in undergraduate students, they have given little attention to measuring undergraduate students’ ability to think critically about sustainability. Therefore, this study utilizes a sequential mixed-methods design to create and validate a scale to measure undergraduate engineering students’ ability to think critically about sustainability called the Critical Thinking about Sustainability Scale (CTSS).
The attachment script representation procedure in an Italian sample: Associations with adult attachment Interview scales and with maternal sensitivity

Abstract This study provides data supporting the reliability and validity of an Italian version of the adult attachment script representation task, designed by Waters & Rodrigues-Doolabh (2004). Specifically, we tested hypotheses concerning positive relations between attachment scriptedness scores and two other representational measures, derived from the Adult Attachment Interview (AAI). In addition, we tested the hypothesis that secure base script scores should predict maternal sensitivity in the context of mother – infant interaction. Thirty-one mothers completed narrative protocols and received scriptedness scores using the Waters & Rodrigues-Doolabh (2004) criteria. Prior to the attachment script assessment, mothers had been assessed using the AAI and had been observed in the context of infant – mother interactions to assess maternal sensitivity. Assessment of instrument reliability was satisfactory (Cronbach's α >.70) and both hypotheses were supported; the attachment scriptedness score (based on 4 attachment narratives) was positively and significantly associated with the AAI coherence score, the continuous security score derived from the AAI State of Mind scales, and with maternal sensitivity. These data extend to another socio-cultural milieu, previous findings supporting reliability, convergent, and predictive validity of the attachment script representation task as a measure of adult attachment.
The Games They Will Play: Tax Games, Roadblocks, and Glitches Under the 2017 Tax Legislation

The 2017 tax legislation brought sweeping changes to the rules for taxing individuals and business, the deductibility of state and local taxes, and the international tax regime. The complex legislation was drafted and passed through a rushed and secretive process intended to limit public comment on one of the most consequential pieces of domestic policy enacted in recent history. This Article is an effort to supply the analysis and deliberation that should have accompanied the bill’s consideration and passage and describes key problem areas in the new legislation. Many of the new changes fundamentally undermine the integrity of the tax code and allow well-advised taxpayers to game the new rules through strategic planning. These gaming opportunities are likely to worsen the bill’s distributional and budgetary costs beyond those expected in the official estimates. Other changes will encounter legal roadblocks, while drafting glitches could lead to uncertainty and haphazard increases or decreases in taxes. This Article also describes reform options for policymakers who will inevitably be tasked with enacting further changes to the tax law in order to undo the legislation’s harmful effects on the fiscal system.
Total Natural Resources Rent Relation with Economic Growth: The Case of Pakistan and India

The GDP per capita are some of the most important parts of today’s global economy. In world all countries depend on GDP per capita for economic growth and indeed, the role of total natural resources rent are very important in development of economic growth. This study is about the total natural resources rent relationship with economic growth in case of Pakistan and India. In this investigation utilized forty five years annually information and secondary time series data is used and test period from January 1970 to December 2017. ADF test is used to check the integration level of variables. And then for to check the relationship co-integration, regression, and VECM tests are used. The study concluded that total natural resources have positive and significant effect on Pakistan and India GDP per capita. Co-integration analysis depict there are 2 co-integrated equation of relationship between variables.
Expression of Class II MHC Antigens in Murine Pancreas After Streptozocin-Induced Insulitis

In this study, most class II antigen expression during streptozocin-induced insulitis was associated with the mononuclear cells infiltrating the pancreas. During the early stages of the insulitis response, phagocytic cells expressing class II antigens and containing β-cell debris were often observed. Although there was de novo expression of class II antigens by ductular epithelium associated with the exocrine portion of the pancreas and transient expression by vascular endothelial cells, the endocrine cells of the islets remained devoid of class II antigens throughout the period of observation (42 days).
Stock Name Changes and Abnormal Returns:An empirical study of the Chinese stock market

Recently, in the Chinese stock market, changing stock names has become a popular investment trend. Some Chinese listed companies change their stock names in attempt to increase company’s value. In order to find the correlation between stock name changes and abnormal returns, we select 97 listed companies in both Shanghai and Shenzhen Stock Exchanges from 2011 to 2014 and sort the companies according to the reasons of stock name changes. Name changes are classified into five categories according to motivations: subjective wills, future development, main business changes, asset reorganization and other reasons. The first two categories are defined as subjective reasons and others are objective reasons. We test the significance of average and cumulative average abnormal returns by using market adjusted model. We find that there are abnormal returns and overreactions in the Chinese stock market. Regression analyses are made to examine the different impact on cumulative abnormal returns for subjective reasons and objective reasons. We observe that no dummy variable is significant, which means that subjective reasons and objective reasons do not have significantly different impact on cumulative abnormal returns.
Forest understory plant and soil microbial response to an experimentally induced drought and heat‐pulse event: the importance of maintaining the continuum

Drought duration and intensity are expected to increase with global climate change. How changes in water availability and temperature affect the combined plant–soil–microorganism response remains uncertain. We excavated soil monoliths from a beech (Fagus sylvatica L.) forest, thus keeping the understory plant–microbe communities intact, imposed an extreme climate event, consisting of drought and/or a single heat‐pulse event, and followed microbial community dynamics over a time period of 28 days. During the treatment, we labeled the canopy with 13CO2 with the goal of (i) determining the strength of plant–microbe carbon linkages under control, drought, heat and heat–drought treatments and (ii) characterizing microbial groups that are tightly linked to the plant–soil carbon continuum based on 13C‐labeled PLFAs. Additionally, we used 16S rRNA sequencing of bacteria from the Ah horizon to determine the short‐term changes in the active microbial community. The treatments did not sever within‐plant transport over the experiment, and carbon sinks belowground were still active. Based on the relative distribution of labeled carbon to roots and microbial PLFAs, we determined that soil microbes appear to have a stronger carbon sink strength during environmental stress. High‐throughput sequencing of the 16S rRNA revealed multiple trajectories in microbial community shifts within the different treatments. Heat in combination with drought had a clear negative effect on microbial diversity and resulted in a distinct shift in the microbial community structure that also corresponded to the lowest level of label found in the PLFAs. Hence, the strongest changes in microbial abundances occurred in the heat–drought treatment where plants were most severely affected. Our study suggests that many of the shifts in the microbial communities that we might expect from extreme environmental stress will result from the plant–soil–microbial dynamics rather than from direct effects of drought and heat on soil microbes alone.
Persistence of adhesive properties in Vibrio cholerae after long-term exposure to sea water.

The effect of exposure to artificial sea water (ASW) on the ability of classical Vibrio cholerae O1 cells to interact with chitin-containing substrates and human intestinal cells was studied. Incubation of vibrios in ASW at 5 degrees C and 18 degrees C resulted in two kinds of cell responses: the viable but non-culturable (VBNC) state (i.e. <0.1 colony forming unit ml-1) at 5 degrees C, and starvation (i.e. maintenance of culturability of the population) at 18 degrees C. The latter remained rod shaped and, after 40 days' incubation, presented a 47-58% reduction in the number of cells attached to chitin, a 48-53% reduction in the number of bacteria adhering to copepods, and a 48-54% reduction in the number of bacteria adhering to human cultured intestinal cells, compared to control cells not suspended in ASW. Bacteria suspended in ASW at 5 degrees C became coccoid and, after 40 days, showed 34-42% fewer cells attached to chitin, 52-55% fewer adhering to copep-ods, and 45-48% fewer cells adhering to intestinal cell monolayers, compared to controls. Sarkosyl-insoluble membrane proteins that bind chitin particles were isolated and analysed by SDS-PAGE. After 40 days incubation in ASW at both 5 degrees C and 18 degrees C vibrios expressed chitin-binding ligands similar to bacteria harvested in the stationary growth phase. It is concluded that as vibrios do not lose adhesive properties after long-term exposure to ASW, it is important to include methods for VBNC bacteria when testing environmental and clinical samples for purposes of public health safety.
Factors affecting social entrepreneurship intentions among agricultural university students in Taiwan

Taiwan’s agriculture is again generating local interest after years of decline as awareness of problems facing development and food safety grows. Agriculture-related social entrepreneurship is seen as a crucial solution to the challenges faced and has gradually become part of mainstream business in rural areas. This study examined whether empathy, social responsibility, social capital and support, and social entrepreneurial self-efficacy affect social entrepreneurial intentions. Through an online and offline survey, a sample of Taiwanese agricultural college students (n=464) were recruited for analysis. The factor analyses supported previous studies and proved that the factor structures of subscales used in this study were stable, with the exception of social entrepreneurial self-efficacy. Multiple regression analysis results indicated that management efficacy was the most prominent factor affecting social entrepreneurial conviction, followed by stakeholder perspective and communication efficacy. In addition, management efficacy was the strongest factor affecting social entrepreneurial preparation, followed by stakeholder perspective and affective empathy. Notably, cognitive empathy was revealed to be negatively associated with social entrepreneurial preparation. Social capital and support were found to have no association with social entrepreneurial intentions.