Miracle-dz/UniFAR-FTUs huggingface dataset:
ADXS11-001 immunotherapy targeting HPV-E7: Preliminary survival data from a P2 study in Indian women with recurrent/refractory cervical cancer.

5529 Background: ADXS11-001 immunotherapy is a live attenuated Listeria monocytogenes (Lm) bioengineered to secrete a HPV16-E7 fusion protein targeting HPV transformed cells. The Lm vector serves as its own adjuvant and infects APC where it naturally cross presents, stimulating both MHC class 1 and 2 pathways resulting in specific T-cell immunity to tumors. Here we describe the preliminary survival data associated with ADXS11-001 administration in Lm-LLO-E7-015, a randomized P2 study being conducted in India in 110 patients with recurrent/refractory cervical cancer who have been treated previously with chemotherapy, radiotherapy or both. Methods: Patients were randomized to either 3 doses of ADXS11-001 at 1 x 109 cfu or 4 doses of ADXS11-001 at 1 x 109cfu with cisplatin chemotherapy. Naprosyn and oral promethazine were given as premedications and a course of ampicillin was given 72h after infusion. Patients received CT scans at baseline and 3, 6, 9, 12 and 18 months. The primary endpoint is overall surviv.
Understanding of Diabetes among Nurses in a Teaching Hospital of Bangladesh

Objective: Diabetes mellitus is a growing public health problem in the world. Health education by health workers is a key factor in the prevention of this chronic disease. The objective of the study was to determine nurses understanding of diabetes mellitus.Methodology: This was a cross-sectional descriptive study carried out at Rajshahi Medical College hospital from August 2010 to February 2011. Registered nurses were questioned about the clinical features, diagnosis, complications and management of diabetes mellitus. The results were analyzed using appropriate statistical method.Results: A total of 86 nurses completed the questionnaire. Majorities were below 50 years and were ward nurses. About 97.7% correctly identified the definition of diabetes mellitus (p < 0.01) and 94.2% identified <7mmol/l as the fasting plasma glucose diagnostic cut off for DM. Cent percent agreed that DM is a chronic disease (p < 0.01). Polyuria (90.3%) and polydypsia (63.7%) were the commonest clinical features of DM identified. Insulin therapy was the most common form of management identified by 67.9% of the subjects. Majority (83.2%) agreed that weight reduction is useful. About two-thirds (67.2%) identified two oral hypoglycaemic drugs while 25 (22.1%) could not identify any type of insulin. Most subjects (94.7%) could correctly identify treatment for hypoglycaemia, with 7.1% of the nurses saying that insulin can be used to treat hypoglycaemic coma. The eye (82.3%) was the most common organ identified as being complicated with DM. Less than half of the nurses could identify the symptoms of diabetic ketoacidosis while about half (50.9%) of the nurses could identify at least one symptom of diabetic ketoacidosis.Conclusion: Nurses knowledge of diabetes mellitus in Rajshahi medical college hospital is good; however, there are deficits in certain aspects of diabetes management. Organization of regular diabetes educational programmes for nurses will improve these deficiencies of knowledge.TAJ 2016; 29(1): 10-15
Microaggression Detection Measurement Impact on White College Students’ Colorblindness

Racial microaggressions can unduly tax people of color. To combat their impact, people need an increased awareness and ability to detect microaggressions when they occur. The present study examined White individuals’ ability to accurately detect microaggressions across 3 conditions with varied exposure to knowledge about microaggressions (control, low-exposure, high-exposure) at preto postintervention. Undergraduate university students (N = 103) were recruited from 2 predominantly White universities. At preand postintervention, participants watched a set of video clips, some of which contained racial microaggressions, answered a series of questions regarding the content of the videos, and completed the Colorblind Racial Attitudes Scale (CoBRAS). Participants watched a 1 hr video on racial microaggressions, read an article on microaggressions, or read an article on positive psychology. CoBRAS total score from pre(M = 62.23, SD = 15.39) to postintervention (M = 61.67, SD = 15.66), t(102) = 3.26, p = . 002, d = . 32, indicated a significant decrease in overall colorblindness and a significant increase in awareness of racial privilege scores from pre(M = 26.67, SD = 7.51) to postintervention (M = 25.51, SD = 7.87), t(102) = 3.28, p = . 001, d = . 32. Awareness of institutional discrimination and blatant racial discrimination did not shift significantly. Results suggest that repeated exposures to videos of microaggressions had a significant effect in increasing awareness of participants’ racial privilege and decreasing colorblind attitudes. This has implications for interventions and future research.
Safety aspects of mobilising acutely ill inpatients

As impaired mobility is an almost inevitable sequelae for patients who are admitted to hospital with an acute life-threatening illness, the physiotherapy management of these patients will often include treatment aimed at maximising mobility and independence. There are many factors that can affect the ability of acutely ill inpatients to tolerate mobilisation, such as their medical background, cardiovascular stability, and respiratory status. Other parameters including haemoglobin, platelet count, white cell count, and more subjective factors, such as the patient's appearance, level of pain, and fatigue, also should be considered. The aim of this article is to provide physiotherapists with comprehensive guidelines regarding safety issues that should be considered prior to and while mobilising acutely ill patients.
The impact of intellectual capital on firms financial performance and market value: Empirical evidence from Italian listed firms

The purpose of this paper is to extend the understanding of Intellectual Capital (IC) in the context of Italian listed firms. In this study, the Valued Added Intellectual Coefficient (VAIC) is employed as a measure of IC to investigate the relationship between IC, firms’ financial performance and market value. The empirical investigation is developed by using data drawn from a sample of 135 Italian listed companies for the period from 2008 to 2017 and performing different Ordinary Least Squares (OLS) regression models. The findings suggest that, when taken in its aggregated form, IC exerts a positive impact on firms’ financial performance measured as firms’ profitability and growth in revenues as well as on market value. However, when considering its components, only Human Capital efficiency shows a positive effect on firms’ financial performance while Structural Capital efficiency and Capital Employed efficiency exhibit a negative effect. Astonishingly, each of the individual IC components negatively influences firms’ market value. Key words: Intellectual capital, intangible assets, valued added intellectual coefficient (VAIC), Italian listed firms, market value, financial performance.
Reducing the dropout rate in a state alcohol rehabilitation facility.

REDUCING THE DROPOUT RATE IN A STATE ALCOHOL REHABILITATION FACILITY SEPTEMBER 1988 SHIRLEY WOOD SNITZER, B.A., UNIVERSITY OF CHICAGO M.S., SARGENT COLLEGE, BOSTON UNIVERSITY Ed.D. , UNIVERSITY OF MASSACHUSETTS Directed by: Professor Sheryl Riechmann Hruska Alcoholism is a pervasive problem affecting one out of three American families. Of the approximately 300,000 alcoholics in the Commonwealth, less than 1 out of 10 will seek alcohol services in 1990. The problem has been both to get clients into treatment and to keep them there. Dropout rates may be 80% for outpatient treatment and more than 30% for inpatient programs. The purpose of this study was to identify some of the sociodemographic and personality characteristics of dropouts and to assess whether an occupational therapy program would help keep more clients in treatment. Eight facilities having 30 day intensive treatment programs were approached in the Spring of 1985 to research the use of occupational therapy in reducing the
Tracing the Origins of Place Branding Research: A Bibliometric Study of Concepts in Use (1980–2018)

Place branding is seriously studied in various academic disciplines. Its impact on strategic development plays a vital role in processes of sustainable urban transformation. Place branding originated in tourism management and over time its research focus spilled over and evolved in environmental science, urban studies and public administration. Scholars and policy makers are currently faced with a myriad of concepts in place branding research, which show considerable overlap but should be carefully distinguished from each other. To increase our understanding of this body of research, this article observes a strong pattern of the concepts in use, in their references to location types (i.e., urban, city, destination, place) and broadcasting activities (branding, marketing, promotion). It builds on this observation by collecting studies from the Scopus database by location type and broadcasting activities (LT–BA) reference pairs and systematically analysing and reviewing these from 1980 to 2018. A total of 2665 articles and reviews were identified and analysed based on (1) occurrences per reference pair, (2) co-occurrences per reference pair, and (3) co-occurrences for each reference pair with other concepts. On that basis, the origin and evolution of the research field including multiple reference pairs in use is explored and described.
Active exploration of training data for improved object detection

This book concerns the problem of object detection, which is defined as finding all instances of an object class of interest and fitting each of them with a tight bounding window. This seemingly easy task for humans is still extremely difficult for machines. However, recent advances in object detection have enabled machines to categorize many classes of objects. Statistical models are often used for representing an object class of interest. These models learn from extensive training sets and generalize with low error rates to unseen data in a highly generic manner. But, these statistical methods have a major drawback in that they require a large amount of training data. We approach this problem by making the process of acquiring labels less tedious and less costly by reducing human labelling effort. Throughout this book, we explore means of efficient label acquisition for realizing cheaper training, faster development time, and higher-performance of object detectors.
Staphylococcus aureus and Staphylococcus epidermidis Strain Diversity Underlying Pediatric Atopic Dermatitis

AL Byrd, Deming, SKB Cassidy; NISC Comparative Sequencing Program. Sci Transl Med. 2017;9(397):eaal4651 Atopic dermatitis (AD) is a complex and multifactorial disease. Authors of previous studies have used traditional typing methods on cultivated isolates or have sequenced a bacterial marker gene to study the skin microbial communities of patients with AD. A shotgun metagenomic sequencing analysis provides greater resolution, elucidating multiple levels of microbial community assembly. Eleven children with moderate to severe AD and 7 healthy children were recruited to the National …
The Phenomenon of Tax Planning in Indonesia: Effect of aggressive tax planning and audit quality on tax shelter

The increasing number of taxpayers who are set to do tax shelters is due to a planned aggressive action to report a lower amount of tax payable. The release of the International Standard on Auditing (ISA) has a major impact on the audit process in Indonesia. ISA No. 240 states that an auditor has a duty to provide directive guidance regarding the responsibility to detect fraud. Therefore, this study aims to look Aggressive Tax Planning whose influence can be minimized by a good quality audit so as to reduce the number of taxpayers who are set to do tax shelter. This research was conducted at companies under manufacturing industry and is listed in Indonesia Stock Exchange. The study population are 402 companies listed in 2011 to 2013. By using a logit regression analysis, this study is not managed to prove that the influence of Aggressive Tax Planning on Tax Shelter will be reduced by the effect of a good quality audit. This study also aims to look at the effect of book tax difference on audit quality in companies that are likely to conduct a tax shelter. The results showed that a high-quality audit is able to reduce the number of book tax difference. Keywords—aggressive tax planning; audit quality; fraudulent tax; tax shelter
Educational Supervision in Public Health Specialty Training: Through the eyes of specialty registrars.

Background: Expectations for the roles and responsibilities of educational and clinical supervisors are set out in General Medical Council and Health Education England guidance documents. Models of supervision vary across regional training programmes in The UK. Registrars were surveyed on their expectations for the supervision relationship as part of a new model of supervision for public health specialty registrars in the East of England. Methods: Registrars were asked to complete an online survey to comment on key areas of the supervision relationship such as operational issues, expectations of the educational supervisor role, registrar responsibilities in the supervision process, and expectations of the relationships between educational and clinical supervisors and the registrar. Results: Fifteen of the 43 registrars in the region responded to the survey. Educational supervisor responsibilities cited by respondents were sign-off of learning outcomes, review of educational progress and feedback, and assistance with identifying new learning opportunities, within and outside the workplace settings. The value of pastoral support, support with conflict resolution, and the importance of consistency among supervisors across the region was also cited. Conclusion: There is a wide variation in registrar expectations of educational (and clinical) supervisor roles, potentially related to registrar seniority and competence progression. Expectations include pastoral support and guidance for personal development, in addition to supervision of training progress. Though it is acknowledged that individual relationships are built mutually by supervisors and registrars, registrars need to own the supervision process to drive trainee-led training. There is a need for consistency in approach to assessment and sign-off of learning outcomes by supervisors.
An OCaml Implementation of Binary Sessions

In this chapter we describe FuSe, a simple OCaml module that implements binary sessions and enables a hybrid form of session type checking without resorting to external tools or extensions of the programming language. The approach combines static and dynamic checks: the former ones are performed at compile time and concern the structure of communication protocols; the latter ones are performed as the program executes and concern the linear usage of session endpoints. We recall the minimum amount of theoretical background for understanding the essential aspects of the approach (Section 11.1) and then describe the API of the OCaml module throughout a series of simple examples (Section 11.2). In the second half of the chapter we detail the implementation of the module (Section 11.3) and discuss a more complex and comprehensive example, also arguing about the effectiveness of the hybrid approach with respect to the early detection of protocol violations (Section 11.4). We conclude with a survey of closely related work (Section 11.5). The source code of FuSe, which is partially described in this chapter and can be used to compile and run all the examples given therein, can be downloaded from the second author’s home page.
Using Social Media to Detect Socio-Economic Disaster Recovery

There has been growing interest in harnessing Artificial Intelligence (AI) to improve situational awareness for disaster management. However, to the authors’ best knowledge, few studies have focused on socio-economic recovery. Here, as a first step toward investigating the possibility of developing an AI-based method for detecting socio-economic recovery, this study provides fundamental insights about the correlations between public sentiment on social media and socio-economic recovery activities as reflected in market data. Our result shows multiple correlations between sentiment on social media and the socio-economic recovery activities involved in restarting daily routines. Conventional socio-economic recovery indicators, such as governmental statistical data, have a significant time lag before publishing. Therefore, by taking advantages of the real timeliness and the effectiveness of seizing communication trends of massive social media data, using public sentiment on social media can improve situational awareness in recovery operations.
Shareholders return and value of manufacturing firms listed on the Nigerian stock exchange

The attainment of going concern concept of an entity relies heavily on its ability to maximize the wealth of its shareholders and value. The prospect of a firm to investors is a function of return, which signals to the market its good governance. The study examined the influence of shareholders’ return on the value of manufacturing firms listed on Nigerian Stock Exchange using annual reports and accounts of 36 selected firms for a period of twenty years, between 2007 and 2016 (720 firm year observations). The results of the multivariate regression analysis (fixed effect) revealed that past dividend, agency cost, debt-equity ratio, and size have significant positive effect on market capitalization of listed manufacturing firms in Nigeria; while earnings per share and sales growth have insignificant negative influence on value of a firm though, the magnitude is immaterial. The study concluded that managers should look beyond the signaling effect of dividend, but place the interests of the key stakeholders (shareholders, management, employees, and loan holders) as well as the growth and expansion of the business at the centre of their decision-making. Especially on the proportion of earnings to be paid as dividend and the nature of dividend policy to be adopted to enhance its value. Key words: Past dividend, earnings, agency cost, market capitalization, stakeholders.
Cultural Content Analysis of Iranian ELT Coursebooks: A Comparison of Vision I & II with English for Pre-University students I & II

This study was conducted to evaluate the cultural contents and cultural elements represented in Vision (I & II) and Pre-University English (I & II). This study also aimed at determining if there were significant differences between these series in terms of cultural content and cultural element representation. To this end, the two ELT coursebook series were selected and analyzed based on Cortazzi and Jin’s (1999) framework and the framework proposed by Adaskou, Britten, and Fahsi (1990). The results revealed that there were significant differences between these two series in terms of cultural contents and cultural elements. While the Vision series contained more L1 and Neutral-cultural contents, Pre-University series showed tendency to contain L2 and L1 cultural contents. With respect to the cultural elements, both series contained more esthetic and semantic cultural elements. This study has implications for EFL curriculum designing in Iran and can make Iranian EFL instructors familiar with the importance of culture as an indispensable part of language.
Improving hand function in cerebral palsy : theory, evidence and intervention

Clinics in Developmental Medicine No. 178 For most children with cerebral palsy, the extent to which they can use their hands is critical to their overall development. Over the last two decades there have been major advances in the understanding of hand function. Particularly in children with cerebral palsy, assessment of hand function has become more exact and the range of possible interventions has expanded. Changes in treatment approaches can be seen in neurorehabilitation, orthopaedic management, developmental pediatrics and rehabilitation including occupational and physical therapy practices. In this book, selected experts from around the world in the fields of neuroimaging, neurology, orthopaedics, anatomy, motor control and motor learning provide fundamental theoretical information for the development of hand function in children with cerebral palsy. The book also shows how theory can be translated into practice by clinicians who provide assessment and intervention services to improve hand use in this population in sections written by researchers in occupational and physical therapy. Linking different fields of knowledge, this book highlights new perspectives and provides the best evidence for different types of intervention. By focusing only on hand function this essential book highlights new concepts for clinicians and others working towards the overall well-being of children with cerebral palsy.
Assessing the organisational climate for creativity in a UK Public Library Service: a case study

The study aims to investigate for the first time library staff's individual perceptions of their work environment with regard to creativity. It uses the conceptual model designed by Amabile et al. (1996) as a framework in order to establish to what extent the internal climate factors that are conducive or deterrent to creativity are identified by library staff in one UK Public Library service. This research is based on a case study and can constitute a benchmark for other library services. The ability to develop a culture that nurtures creativity is crucial and does not occur spontaneously: library managers need to take responsibility to establish the right work environment as well as to incorporate an innovation strategy for the new ideas to be implemented into value-added services for the library users.
Understanding contextual factors affecting the adoption of energy-efficient household products in Jordan

Purpose This paper aims to examine contextual factors affecting intention to purchase energy-saving products (ESPs), via a research model integrating environmental awareness, perceived performance risk and perceived financial risk with the theory of reasoned action (TRA). Design/methodology/approach In total, 474 targeted Jordanian householders completed a structured survey, providing data for exploratory and confirmatory factor analyses and for structural path analysis to test the research model and hypotheses. Findings Attitude most strongly predicts purchase intention. Environmental awareness positively influences subjective norms and reduces perceived performance and financial risks, which are related to purchase intention. Research limitations/implications This research examines perceived performance and financial risks. Others including social and physical risks have research potential. Future research on international marketing strategy and cross-cultural consumer behavior could compare Jordan with its oil-producing neighbors. Practical implications Environmental awareness affects ESP purchase intention. Marketing strategy should focus on reducing perceived functional and financial risks while enhancing subjective norms by encouraging positive word of mouth. Social implications The findings enhance environmental sustainability by indicating ways of reducing energy consumption and increasing the usage of environmentally friendly products. The study addresses behavioral and social aspects of green products, whereas most ESP suppliers focus on technology. Originality/value The study’s major theoretical contribution is incorporating perceived risk and environmental awareness into the TRA to better understand intention to purchase ESPs. Empirically, it conceptualizes and tests an integrated model of determinants of attitudes and intentions with new insights from an emerging market.