Miracle-dz/UniFAR-FTUs huggingface dataset:
Drinking course through midlife based on diagnostic versus quantity-frequency indices.

BACKGROUND Prior efforts to examine the course of drinking from onset to midlife have been limited to analyses of year-to-year changes in alcohol dependence (AD). The current investigation sought to examine the course of drinking over this time frame using consumption-based measures of drinking and evaluate the degree of comparability in trajectories estimated from diagnostic and quantity-frequency data. METHODS Participants included 420 men with a lifetime history of AD who were drawn from the Vietnam Era Twin Registry and administered the Lifetime Drinking History, which provided person-year (retrospective) data on patterns of consumption and diagnostic symptoms from drinking onset to participants' current age. Consumption-based data were aggregated into age categories that ranged from "up to age 20" to "ages 54 to 56" and analyzed separately as a dichotomous measure of "heavy drinking (HD)" and continuous quantity-frequency index (QFI) scores. RESULTS Using latent growth mixture modeling, trajectories based on the HD measure were moderately concordant with those based on changes in AD that were previously identified in this sample, whereas trajectories based on QFI scores were only weakly related to those based on AD diagnoses. Moreover, examination of the degree of concordance between AD- and QFI-derived trajectories revealed that measures of consumption (and potentially other continuous indices of drinking) may qualify past interpretations of various developmental trajectories that have been discussed in the alcoholism typology literature (particularly "Late Onset" alcoholism). CONCLUSIONS Collectively, the findings highlight the importance of integrating repeated measures of alcohol consumption in future efforts to describe the course of drinking across the life span.
A study of the condition number of various finite element matrices involved in the numerical solution of Maxwell's equations

We consider the solution of the time-harmonic Maxwell's equations inside a bounded domain on the boundary of which various conditions are prescribed, including a perfectly matched layer (PML) termination. This problem arises when, e.g., the electromagnetic fields scattered from an inhomogeneous penetrable structure are computed by using a hybrid finite element (FE) and integral equation method in conjunction with a domain decomposition technique. In each of the subdomains, the discretization process leads to a linear system, and an iterative solver may be advantageously utilized when the number of unknowns is large. In this case, the number of iterations and, hence, the computational time required to achieve a given numerical accuracy are known to increase with the condition number /spl kappa/ of the FE matrix. In this paper, we attempt to draw the rules that govern the behavior of /spl kappa/. To this effect, an eigenmodes technique is proposed that allows to dissociate the influence of the FE mesh and FE basis functions from the one of the actual physical cavity. Numerical examples are provided for one- and three-dimensional problems that illustrate the results so obtained.
Structure, fragmentation patterns, and magnetic properties of small cobalt oxide clusters.

The favorable stoichiometry of Co(n)O(m)(+) clusters has been recently determined by means of multiphoton dissociation of oxide cluster beams coming from laser evaporation of metal rods seeded with 0.5-5% oxygen and selected by time of flight mass spectroscopy. It was observed that the prominent stoichiometry is n = m, and that the preferred dissociation channel is the loss of O2 molecules. The Co4O4(+) cluster is found to be particularly abundant, an indication of its high stability. In this work we present density functional calculations, within the generalized gradient approximation, for the geometric, electronic, and magnetic properties of neutral and cationic Co(n)O(m)(0/+) clusters with n = 3-8 and m = 1-10. The ionic structures were determined after optimizing several initial geometries selected from previous calculations of pure Co clusters, with consecutive adsorbed oxygen atoms, as well as geometries constructed by assembling several CoO units and adding subsequent oxygen atoms. The fragmentation patterns were studied by comparing the energy separation of O2, CoO, Co2O, CoO2, and Co fragments. We obtain that the preferred fragmentation channel is the loss of O2, that the favourable stoichiometry is 1 : 1, and that Co4O4(+) is especially stable, in full agreement with the experiments. In addition the magnetic properties related to spin isomeric configurations of (CoO)n(+) clusters are studied in detail.
Using Stacking to Average Bayesian Predictive Distributions (with Discussion)

The widely recommended procedure of Bayesian model averaging is flawed in the M-open setting in which the true data-generating process is not one of the candidate models being fit. We take the idea of stacking from the point estimation literature and generalize to the combination of predictive distributions, extending the utility function to any proper scoring rule, using Pareto smoothed importance sampling to efficiently compute the required leave-one-out posterior distributions and regularization to get more stability. We compare stacking of predictive distributions to several alternatives: stacking of means, Bayesian model averaging (BMA), pseudo-BMA using AIC-type weighting, and a variant of pseudo-BMA that is stabilized using the Bayesian bootstrap. Based on simulations and real-data applications, we recommend stacking of predictive distributions, with BB-pseudo-BMA as an approximate alternative when computation cost is an issue.
Quantifying the strength of the associations of prototype perceptions with behaviour, behavioural willingness and intentions: a meta-analysis

Prototypes (i.e., social images representing perceptions of typical persons engaging in or refraining from certain behaviour) have been shown to explain health-related behaviours. The present meta-analysis quantified the strength of the associations of prototype perceptions with health motivation and behaviour. Specifically, the analysis addressed (i) the relationship of prototype favourability (i.e., degree of likability) and similarity (i.e., perceived resemblance to the self) with behaviour, willingness and intentions; (ii) the effect of the interaction between favourability and similarity; and (iii) the extent to which health-risk and health-protective prototypes differed in their association with these outcomes. A total of 80 independent studies were identified based on 69 articles. The results indicated that prototype favourability and similarity were related to behaviour, intentions and willingness with small-to-medium effect sizes (r+ = 0.12–0.43). Direct measures of prototype perceptions generally produced larger effects than indirect measures. The interaction between favourability and similarity produced small-to-large effect sizes (r+ = .22–.54). The results suggest that both health-risk and health-protective prototypes might be useful targets for interventions (r+ = .22–.54). In order to increase health-protective behaviours, intentions and behaviour could be targeted by increasing similarity to health-protective prototypes. Health-risk behaviour might be decreased by targeting willingness by modifying health-risk prototype favourability and similarity.
Immunohistochemical analysis of sustentacular cells in the adrenal medulla, carotid body and sympathetic ganglion of mice using an antibody against brain‐type fatty acid binding protein (B‐FABP)

Little attention has been paid to adrenal sustentacular cells, and several major histology textbooks do not even describe them. This study presents a detailed morphological description of sustentacular cells using immuno‐light microscopy and an antibody against brain‐type fatty acid‐binding protein. The immunopositive sustentacular cells and processes formed lattices with holes of various sizes and compactnesses or openness. In addition, weakly immunostained sheet‐like structures with ill‐defined contours were often associated with the processes and lattices. In the carotid body, which has traditionally been classified under the name of paraganglia in common with the adrenal medulla, immunostained sustentacular cell processes formed lattices in association with the weakly immunostained sheet‐like structures, but the lattices with sheets were more compact and rigid than the adrenal medulla, and appeared like individually distinct compartments. In the ganglion, the immunostained satellite cell processes with the sheets tightly enclosed individual neurons. As a result, the immunostained sheet‐like structures were regarded as en‐face views of thinly flattened sustentacular cytoplasmic envelopes partially covering the chromaffin cells in the adrenal medulla, and widely in the carotid body in a way rather similar to the satellite cells in the ganglion. In brief, the terminal enclosing portions of adrenal sustentacular cell processes, in cut‐views, were too thin/flat to be recognized as distinct lines in immuno‐light microscopy because of its resolution limit. They are recognized in en‐face views as entities of a substantially spacious extension in immuno‐light microscopy.
Evidence for a cannabinoid receptor in sea urchin sperm and its role in blockade of the acrosome reaction

Delta‐9‐tetrahydrocannabinol ((−)δ9 THC), the primary psychoactive cannabinoid in marihuana, reduces the fertilizing capacity of sea urchin sperm by blocking the acrosome reaction that normally is stimulated by a specific ligand in the egg's jelly coat. The bicyclic synthetic cannabinoid [ H]CP‐55,940 has been used as a ligand to demonstrate the presence of a cannabinoid receptor in mammalian brain. We now report that [ H]CP‐55,940 binds to live sea urchin (Strongylocentrotus purpuratus) sperm in a concentration, sperm density, and time‐dependent manner. Specific binding of [ H]CP‐55,940 to sperm, defined as total binding displaced by (−)δ9 THC, was saturable: KD 5.16 ± 1.02 nM; Hill coefficient 0.98 ± 0.004. This suggests a single class of receptor sites and the absence of significant cooperative interactions. Sea urchin sperm contain 712 ± 122 cannabinoid receptors per cell. Binding of [ H]CP‐55,940 to sperm was reduced in a dose‐dependent manner by increasing concentrations of CP‐55,940, (−)δ9 THC, and (+)δ9 THC. The rank order of potency to inhibit binding of [ H]CP‐55,940 to sperm and to block the egg jelly stimulated acrosome reaction was: CP‐55,940 > (−)δ9THC > (+)δ9THC. These findings show that sea urchin sperm contain a stereospecific cannabinoid receptor that may play a role in inhibition of the acrosome reaction. The radioligand binding data obtained with live sea urchin sperm are remarkably similar to those previously published by other investigators using [ H]CP‐55,940 on mammalian brain and nonneural tissues. The cannabinoid binding properties of this receptor appear to have been highly conserved during evolution. We postulate that the cannabinoid receptor may modulate cellular responses to stimulation. © 1993 Wiley‐Liss, Inc.
Economic Implications

The policies of the Standard Oil Company (New Jersey) are headline news. The fact that Standard's policies are not spoken of as “public” policies is little more than an accident of terminology; certainly they are public in their sweep and import, and certainly in their impact upon the public mind. The policies and actions of Standard (New Jersey) are not alone in these respects. Standard is a giant corporation; there are other giant corporations and there are more in the making.
Hydrogen Peroxide Triggers Nuclear Export of Telomerase Reverse Transcriptase via Src Kinase Family-Dependent Phosphorylation of Tyrosine 707

ABSTRACT The regulation of telomerase reverse transcriptase (TERT) plays an important role in the proliferative capacity and survival of cells. Here, we report that exogenously as well as endogenously induced oxidative stress leads to translocation of endogenous as well as overexpressed human TERT from the nucleus into the cytosol. TERT is transported through the nuclear pores in a leptomycin-sensitive and Ran GTPase-dependent process. H2O2-induced nuclear export of TERT is preceded by TERT tyrosine phosphorylation at position 707 and prevented by the Src kinase family inhibitor PP1. Oxidative stress-induced nuclear export of TERT depends on association with the Ran GTPase. In contrast, mutation of tyrosine 707 inhibits phosphorylation induced by oxidative stress and prevents association with Ran and nuclear export of TERT. Moreover, inhibition of tyrosine phosphorylation at 707 increases the antiapoptotic capacity of TERT. Taken together, depletion of nuclear TERT by tyrosine phosphorylation-dependent nuclear export of TERT is a novel mechanism for regulation of TERT localization, which reduces the antiapoptotic activity of TERT.
A New Model of Identifying Differentially Expressed Genes via Weighted Network Analysis Based on Dimensionality Reduction Method

As a method to identify Differentially Expressed Genes (DEGs), Non- Negative Matrix Factorization (NMF) has been widely praised in bioinformatics. Although NMF can make DEGs to be easily identified, it cannot provide more associated information for these DEGs. The methods of network analysis can be used to analyze the correlation of genes, but they caused more data redundancy and great complexity in gene association analysis of high dimensions. Dimensionality reduction is worth considering in this condition. In this paper, we provide a new framework by combining the merits of two: NMF is applied to select DEGs for dimensionality reduction, and then Weighted Gene Co-Expression Network Analysis (WGCNA) is introduced to cluster on DEGs into similar function modules. The combination of NMF and WGCNA as a novel model accomplishes the analysis of DEGs for cholangiocarcinoma (CHOL). Some hub genes from DEGs are highlighted in the co-expression network. Candidate pathways and genes are also discovered in the most relevant module of CHOL. The experiments indicate that our framework is effective and the works also provide some useful clues to the reaches of CHOL.
The Antecedents of Individual Innovative Behaviour in Temporary Group Innovation

This study examines the antecedents of individual innovative behaviour in short-term innovation camp conditions. Innovation is increasingly a joint activity conducted in various kinds of temporary settings that collect widely diverse people together for a brief time to work on a particular problem. As innovativeness of interplaying individuals is key for the success of collaborative innovation, it is important to study what factors enhance individual innovative behaviour in temporary settings. Data from 103 innovation camp participants were the basis of PLS-SEM analysis. Results show that individual creative self-efficacy, perceived task orientation and experimentation have significant effects on individual innovative behaviour. In contrast, participative safety, support for innovation, and vision are not associated with individual innovativeness. These findings suggest that the antecedents of individual innovativeness in temporary settings differ from those identified in conventional groups, pointing to a new field for future research.
Developmental regulation of neuron‐specific P2X3 receptor expression in the rat cochlea

ATP‐gated ion channels assembled from P2X3 receptor (P2X3R) subunits contribute to neurotransmission and neurotrophic signaling, associated with neurite development and synaptogenesis, particularly in peripheral sensory neurons. Here, P2X3R expression was characterized in the rat cochlea from embryonic day 16 (E16) to adult (P49–56), using RT‐PCR and immunohistochemistry. P2X3R mRNA was strongly expressed in the cochlea prior to birth, declined to a minimal level at P14, and was absent in adult tissue. P2X3R protein expression was confined to spiral ganglion neurons (SGN) within Rosenthal's canal of the cochlea. At E16, immunolabeling was detected in the SGN neurites, but not the distal neurite projection within the developing sensory epithelium (greater epithelial ridge). From E18, the immunolabeling was observed in the peripheral neurites innervating the inner hair cells but was reduced by P6. However, from P2–8, immunolabeling of the SGN neurites extended to include the outer spiral bundle fiber tract beneath the outer hair cells. This labeling of type II SGN afferent fiber declined after P8. By P14, all synaptic terminal immunolabeling in the organ of Corti was absent, and SGN cell body labeling was minimal. In adult cochlear tissue, P2X3R immunolabeling was not detected. Noise exposure did not induce P2X3R expression in the adult cochlea. These data indicate that ATP‐gated ion channels incorporating P2X3R subunit expression are specifically targeted to the afferent terminals just prior to the onset of hearing, and likely contribute to the neurotrophic signaling which establishes functional auditory neurotransmission. J. Comp. Neurol. 484:133–143, 2005. © 2005 Wiley‐Liss, Inc.
High bax expression is a good prognostic indicator in acute myeloid leukaemia

Most cytotoxic drugs kill cells by instigating the process of apoptosis and it has been suggested that apoptotic markers may provide an indication of tumour chemosensitivity. The aim of this study was to determine if such a relationship exists in acute myeloid leukaemia (AML). The levels of spontaneous apoptosis, bcl‐2 and bax were evaluated in 56 newly diagnosed AML patients to determine if they correlated with a response to cytotoxic therapy. Spontaneous apoptosis was lower, but bcl‐2, bax and the bcl‐2/bax ratio were higher in AML compared with normal individuals. AML patients with high bax expression at diagnosis had significantly better prognosis for disease‐free survival, event‐free survival and overall survival (P = 0·016). In the standard risk group, high bax expression was in keeping with significantly improved survival. Multivariate analysis revealed bax to be an independent predictor of survival. There was a significant reduction in bcl‐2 and bax expression when AML patients entered complete remission and also in relapsed AML patients who entered a second remission. This study suggests that bax is a useful prognostic indicator in AML and may assist with therapeutic decision‐making for patients in the standard risk category.
Community size and sport participation across 22 countries

The objective of this study was to examine, across 22 countries, the association between community size and individual sport, team sport, and exercise participation. Hierarchal non‐linear Bernoulli modeling is used to examine the association between community size (100 000–10 000; <10 000) and (a) individual sport, (b) team sport, and (c) exercise participation. After controlling for country‐level clustering and demographic variables, those residing a community with between 100 000 and 10 000 residents are more likely to participate in individual sport [odds ratio (OR) = 1.14; 95% confidence interval (CI) = 1.05–1.23] while residing in a community with less than 10 000 residents is unrelated (OR = 1.06; 95% CI = 0.96–1.19). Those residing in communities with between 100 000 and 10 000 residents were more likely to participate in team sport (OR = 1.21; 95% CI = 1.01–1.45) while residing in a community with less than 10 000 residents is unrelated (OR = 1.02; 95% CI = 0.88–1.18). Residing in a community with between 100 000 and 10 000 residents is unrelated to exercise participation (OR = 0.97; 95% CI = 0.89–1.7), while residing in a community with less than 10 000 residents is negatively related to exercise participation (OR = 0.86; 95% CI = 0.79–0.93). These findings provide novel evidence that communities between 100 000 and 10 000 residents are related to increased sport participation, particularly team sport participation.
[Fear and anxiety].

By means of a phenomenologic-existential approach, the author presents a summarized study on anguish, taking into account the descriptions Schelling, Kierkegaard and Heidegger wrote about. He considers that, inspired by different problematics and thanks to their respective investigations, those philosophers represent a comprehensive 'model' for the clinico-psychological and psychiatric understanding of every kind of development where anguish is the 'axial' symptom.
LISA capture sources: Approximate waveforms, signal-to-noise ratios, and parameter estimation accuracy

Captures of stellar-mass compact objects (COs) by massive ($\sim 10^6 M_\odot$) black holes (MBHs) are potentially an important source for LISA, the proposed space-based gravitational-wave (GW) detector. The orbits of the inspiraling COs are highly complicated; they can remain rather eccentric up until the final plunge, and display extreme versions of relativistic perihelion precession and Lense-Thirring precession of the orbital plane. The strongest capture signals will be ~10 times weaker than LISA's instrumental noise, but in principle (with sufficient computing power) they can be disentangled from the noise by matched filtering. The associated template waveforms are not yet in hand, but theorists will very likely be able to provide them before LISA launches. Here we introduce a family of approximate (post-Newtonian) capture waveforms, given in (nearly) analytic form, for use in advancing LISA studies until more accurate versions are available. Our model waveforms include most of the key qualitative features of true waveforms, and cover the full space of capture-event parameters (including orbital eccentricity and the MBH's spin). Here we use our approximate waveforms to (i) estimate the relative contributions of different harmonics (of the orbital frequency) to the total signal-to-noise ratio, and (ii) estimate the accuracy with which LISA will be able to extract the physical parameters of the capture event from the measured waveform. For a typical source (a $10 M_\odot$ CO captured by a $10^6 M_\odot$ MBH at a signal-to-noise ratio of 30), we find that LISA can determine the MBH and CO masses to within a fractional error of $\sim 10^{-4}$, measure $S/M^2$ (where $S$ and $M$ are the MBH's mass and spin) to within $\sim 10^{-4}$, and determine the sky location of the source to within $\sim 10^{-3}$ stradians.
Transforming our World:Literacy for Sustainable Development

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