Miracle-dz/UniFAR-FTUs huggingface dataset:
iont with a Drastically Reduced Genome

Atsushi Nakabachi,1,2,* Reiko Ueoka,3,4 Kenshiro Oshima,6 Roberta Teta,7 Alfonso Mangoni,7 Mihaela Gurgui,5 Neil J. Oldham,8 Gerhild van Echten-Deckert,5 Keiko Okamura,1 Kohei Yamamoto,1 Hiromitsu Inoue,9 Moriya Ohkuma,2 Yuichi Hongoh,10 Shin-ya Miyagishima,11 Masahira Hattori,6 Jörn Piel,3,4 and Takema Fukatsu12 1Electronics-Inspired Interdisciplinary Research Institute (EIIRIS), Toyohashi University of Technology, Toyohashi 441-8580, Japan 2Japan Collection of Microorganisms, RIKEN BioResource Center, Tsukuba 305-0074, Japan 3Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, 8093 Zurich, Switzerland 4Kekulé Institute of Organic Chemistry and Biochemistry 5LIMES Institute forMembraneBiology and Lipid Biochemistry at the Kekulé Institute University of Bonn, 53121 Bonn, Germany 6Graduate School of Frontier Sciences, University of Tokyo, Kashiwa 277-8561, Japan 7Dipartimento di Farmacia, Università di Napoli Federico II, 80131 Napoli, Italy 8School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UK 9Citrus Research Division, National Institute of Fruit Tree Science, Kuchinotsu 859-2501, Japan 10Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Tokyo 152-8550, Japan 11Center for Frontier Research, National Institute of Genetics, Mishima 411-8540, Japan 12Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba 305-8566, Japan
Efficacy of Topical and Systemic Vitamin E in Preventing Chemotherapy-Induced Oral Mucositis

Background: There is still no consensus regarding the optimum treatment of chemotherapy-induced oral mucositis and its management is still mainly supportive. Vitamin E has been shown to be effective in reducing the symptoms of oral mucositis. Objectives: Aim of this study was to assess the efficacy of prophylactic systemic and topical vitamin E in reducing the signs and symptoms of oral mucositis in patients receiving chemotherapy. Patients and Methods: We conducted a placebo-controlled randomized clinical trial among 76 patients with a hematologic malignancy treated with chemotherapy. Patients were randomly assigned into three groups: supplementation with vitamin E paste (group 1) and 200 mg/d vitamin E pills (group 2). Group 3 received placebo paste, identical in appearance and taste to the vit E paste, but consisting of the vehicle only. Patients were advised to use the administered medication from two days before each cycle of chemotherapy till at least 20 days after completion of each cycle. Oral exam was performed 10-14 days after each cycle of chemotherapy. Results: Patients in group 2 and 3 did not show any difference in degree of mucositis or severity of pain. However, after the second cycle, patients who were treated with topical vitamin E showed significantly less oral pain, and had fewer cases of severe mucositis compared to groups 2 and 3. Conclusions: Topical vitamin E could be beneficial in reducing the severity of oral mucositis, but no therapeutic gain would be achieved by using systemic vitamin E in this regard.
Engset loss models for an OBS/OPS node with shared wavelength conversion

Asynchronous bufferless OBS/OPS core nodes behave as loss systems and therefore, widely analyzed under traditional Erlang and Engset loss models. Additionally, it has been shown that the Engset traffic assumptions are more realistic with a correction in the offered load. This correction is proposed due to the fact that in case of loss, the source cannot offer a new packet while the input wavelength is busy in transmitting a lost packet. This effect is more evident in OBS switches which deals with large burst lengths compared with packets. In this study, Engset traffic model with and without correction in the offered load is used to analyze a switch using the shared wavelength conversion. We show that the degree of wavelength conversion also effect the blocking of the switch significantly and in the switches with small and medium port counts the effect of blocked inputs due to packets/bursts should not be ignored. Continuous time Markov chains have been used for analysis and expressions have been derived to evaluate the time, traffic and call blocking.
Physiological and catecholamine response to sympathetic stimulation in turner syndrome

Objective Women with Turner syndrome have increased heart rate and high blood pressure (BP), and have been described as having high tolerance for emotional stress. We hypothesized that women with Turner syndrome have reduced catecholaminergic and physiological response to sympathetic stimulation, and that changes in BP and heart rate are related to their catecholamine response to sympathetic stimulation.
Looking Back Towards the Future: Is It Time to Change the DSM Approach to Psychiatric Disorders? The Case of Depression

Abstract With plans underway for the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM), the debate between proponents of an atheoretical, descriptive approach of mental disorders versus an etiologically based classification system has been revitalized. This paper critically reviews findings from three related research areas that have begun to question the atheoretical, descriptive approach to mental disorders of DSM–III and its successors: (a) research concerning the underlying assumptions of DSM, (b) findings from treatment research, and (c) recent biopsychosocial research. Research on depression is used as a paradigmatic example, but the extent to which these findings may generalize to other disorders is also discussed. Strengths and weaknesses of the current DSM approach versus a more etiologically based classification system are considered. This review shows that although an etiologically based classification system of mental disorders seems more promising than a purely descriptive approach, the time seems not yet ripe for such a radical shift in psychiatric diagnosis. Further research oriented towards developing a more etiologically based approach to diagnosis is urgently needed, taking into account research, clinical, and policy implications that such a change in the diagnosis of mental disorders would bring.
The effects of local scattering on direction of arrival estimation with MUSIC and ESPRIT

In wireless communication scenarios, multipath propagation from local scatterers in the vicinity of mobile sources may cause angular spreading as seen from a base station antenna array. This paper studies the effects of such local scattering on direction of arrival (DOA) estimation with the MUSIC and ESPRIT algorithms. Previous work has considered rapidly time-varying scenarios, and concluded that local scattering has a minor effect on DOA estimation in such scenarios. This work considers the case in which the channel is time-invariant during the observation period. The distribution of the DOA estimates is derived, and the results show that local scattering has a significant impact on DOA estimation in the time-invariant case. In addition, numerical examples are included to illustrate the analysis, and to demonstrate that the results may be used to formulate simple estimators of angular spread.
An activity-based freight mode choice microsimulation model

Abstract This study embarked upon the development of a nationwide freight activity microsimulation as an acceptable analysis tool for policy assessments. Mode choice component of a large-scale behavioral microsimulation framework, named Freight Activity Microsimulation Estimator (FAME) was developed and validated in this study. The results of a nationwide establishment survey, discussed in earlier studies, are used to develop the mode choice model for the entire US. Despite many previous freight mode choice models, the proposed model works at the disaggregate level of firm-to-firm. A new concept for firm-types is implemented in FAME to keep the computational burden at a reasonable level and to diminish the need for highly disaggregated data. A total of 45 206 firm-types were synthesized in the US, among which more than 14·8 billion tonnes of domestic shipments were simulated. Total tonnage, value, and tonne-mile of commodities for each mode were obtained as the final output, which showed a satisfactory match with public freight data in the US.
Soluble membrane‐type 1 matrix metalloproteinase (MT1‐MMP) and gelatinase A (MMP‐2) in induced sputum and bronchoalveolar lavage fluid of human bronchial asthma and bronchiectasis

The aim of this study was to investigate the involvement of the MT1‐MMP/MMP‐2 cascade in induced sputum (IS) and bronchoalveolar lavage fluid (BALF) from bronchial asthma (BA) and bronchiectasis (BE) patients and healthy controls. The molecular forms and cellular origins of MT1‐MMP and MMP‐2 were determined by Western immunoblotting, immunohistochemistry and in situ hybridization. Elevated levels of soluble activated and autocatalyzed MT1‐MMP species as well as activated forms of MMP‐2 in IS and BALF samples from BA and BE patients were evidenced. The activation degrees of soluble MT1‐MMP and MMP‐2 were significantly correlated in BA and BE IS and BALF. Only low levels of both these MMPs were observed in healthy control IS and BALF. The co‐expression of MMP‐2 with MT1‐MMP was evidenced by double immunostaining in bronchial epithelial cells, submucosal glandular cells, smooth muscle cells and monocyte/macrophages. The MT1‐MMP/MMP‐2 cascade is present and active in human inflammatory lung disease fluid and tissue samples. This cascade seemingly reflects the active destructive phases of these chronic lung diseases.
Diversity of Potassium Channels in Human Umbilical Artery Smooth Muscle Cells

Through their control of cell membrane potential, potassium (K+) channels are among the best known regulators of vascular tone. This article discusses the expression and function of K+ channels in human umbilical artery smooth muscle cells (HUASMCs). We review the bibliographic reports and also present single-channel data recorded in freshly isolated cells. Electrophysiological properties of big conductance, voltage- and Ca2+-sensitive K+ channel and voltage-dependent K+ channels are clearly established in this vessel, where they are involved in contractile state regulation. Their role in the maintenance of membrane potential is an important control mechanism in the determination of the vessel diameter. Additionally, small conductance Ca2+-sensitive K+ channels, 2-pore domains K+ channels and inward rectifier K+ channels also appear to be present in HUASMCs, while intermediate conductance Ca2+-sensitive K+ channels and ATP-sensitive K+ channels could not be identified. In both cases, additional investigation is necessary to reach conclusive evidence of their expression and/or functional role in HUASMCs. Finally, we discuss the role of K+ channels in pregnancy-related pathologies like gestational diabetes and preeclampsia.
Predictor variables for and complications associated with Streptococcus equi subsp equi infection in horses.

OBJECTIVE To evaluate predictor variables for and complications associated with Streptococcus equi subsp equi infection (strangles) in horses. DESIGN Retrospective case-control study. ANIMALS 108 horses with strangles (cases) and 215 horses without strangles (controls). PROCEDURES Medical records from January 2005 through July 2012 were reviewed. Cases were defined as horses with clinical signs of strangles (pyrexia, retropharyngeal lymphadenopathy, and mucopurulent nasal discharge) that were associated with a confirmed strangles outbreak or had positive results for S equi on PCR assay or bacteriologic culture. Controls were defined as horses with pyrexia that did not meet the other criteria for cases. Data compared between cases and controls included signalment, clinical signs, diagnostic test results, and disease complications and outcome. Logistic regression was used to identify variables associated with strangles and its complications. RESULTS Clinical signs of strangles were not evident in 12 of 25 cases classified as S equi carriers (infected > 40 days). Predictor variables associated with strangles included mucopurulent nasal discharge and external abscesses in the pharyngeal region. Strangles was more likely to be diagnosed in the spring than in the summer. Cases with anemia were more likely to develop purpura hemorrhagica than were cases without anemia. No risk factors were identified for the development of guttural pouch empyema or metastatic abscesses. CONCLUSIONS AND CLINICAL RELEVANCE Results indicated that not all horses infected with S equi develop clinical signs of strangles. We recommend that guttural pouch endoscopy and lavage with PCR assay of lavage fluid samples be performed to identify S equi carrier horses.
A Clinical Research about the Intermittent Medication Treatment on the Female Urogenital Tract Mycoplasma Infection

Object: To explore a better treatment on the female urogenital tract mycoplasma infection so as to ensure the health of female reproduction. Method: 115 female patients with urogenital tract mycoplasma infection are selected, including 63 patients acted as a group for intermittent medi- cation treatment; that is to say, the ones that are confirmed to be sensitive drugs to those 63 pa- tients are chosen, and let them take this medication for 15 days and stop taking it for 7 days and after that continue to take it for 10 days. The other 52 patients in the other group which acts as a contrast to the former group are cured with a course of conventional treatment for 15 - 21 days. Results: As to those 115 female patients with urogenital tract mycoplasma infection, 43 patients get relapsed, and 27 patients of them are in the contrast group and 16 patients are in the treat- ment group. There is obvious difference on the contrast of relapse rate between the treatment group and contrast group, and they are P < 0.01. But as to the sensitive testing results of 10 com- mon antibiotic medicines, there are cases of illness of relapse in those 2 groups, and the rate of drug sensitivity in the treatment group is higher than that of the contrast group. Between treat- ment group and contrast group, there is obvious difference in the sensitivity of the drugs, P < 0.05 average. Conclusion: When the female patients with urogenital tract mycoplasma infection are cured with a traditional treatment, because of the side effects of drugs, they are not likely to take medicines that are required to making the cure rate become lower and the relapse rate become higher. But intermittent medication is designed with the half-life period of medicine, which makes the medicine can be digested and absorbed easily, and the cure rate is high and the relapse rate is low. With this research we found a more effective method of the treatment on the female uroge- nital tract mycoplasma infection and showed the clinical significance in intermittent medication. * Corresponding author.
Configural Algorithms of Patient Satisfaction, Participation in Diagnostics, and Treatment Decisions' Influences on Hospital Loyalty

Purpose – This empirical study aims to explore sufficiency conditions for patient loyalty to a hospital. Design/methodology/approach – The study collected 645 self-administered questionnaires from patients in a major medical center in Taiwan and applied fuzzy set qualitative comparative analysis (fs/QCA) to explore the sufficiency conditions for patient loyalty. Findings – The findings support the conclusion that the three conditions (patient satisfaction, patient participation in the process of diagnosis, and patient participation in treatment decision-making) in combination are sufficient for high patient loyalty to the hospital but high patient satisfaction alone is insufficient. While the three conditions in configural algorithm are sufficient, this expression is not necessary, which means the findings do not reject possible alternative conditions for high patient loyalty. Research limitations/implications – The study applies a relatively new method, fuzzy set qualitative comparative analysis (fs/QCA).
Affect Regulation, Brain Development, and Behavioral/Emotional Health in Adolescence

Abstract This paper addresses the importance of affect regulation (AR) in relation to a broad range of behavioral and emotional health problems that emerge during adolescence. AR is defined as the adaptive modulation of emotional experience to serve a goal or purpose. This conceptualization of AR emphasizes the use of cognitive skills to guide, inhibit, or modify emotion and behavior, including the expression of emotional responses, in learned, strategic ways—skills that ultimately underpin adult levels of social maturity and the ability to show “responsible” behavior across a range of emotional situations. Neurobehavioral systems that subserve these AR skills include areas of the inferior and orbital prefrontal cortex (PFC), with rich interconnections to several limbic structures and other cortical areas, including the dorsolateral PFC. Adolescence represents an important developmental period in the functional maturation of adult AR skills; it is also a critical time in the development of clinical disorders of AR (eg, rates of depression increase dramatically and gender differences in depression emerge). Maturational changes in AR that occur during adolescence—particularly with respect to the role of emotions influencing responsible decision making—are also relevant to understanding key aspects of the developmental pathways of some behavioral health problems, such as alcohol use and nicotine dependence. A strong case is made for developmental research in affective neuroscience aimed at this important maturational period, particularly the kind of transdisciplinary research leading toward mechanistic understanding of the development of adolescent-onset disorders. Improving understanding in these areas could ultimately lead to the development of early interventions in targeted high-risk populations, and has enormous clinical and social policy relevance.
Fish Oil Decreases Oxidative DNA Damage by Enhancing Apoptosis in Rat Colon

Abstract: To determine if dietary fish oil protects against colon cancer by decreasing oxidative DNA damage at the initiation stage of colon tumorigenesis, oxidative DNA damage, proliferation, and apoptosis were assessed by colonic crypt cell position using quantitative immunohistochemical analysis of 8-hydroxydeoxyguanosine (8-OHdG), Ki-67, and TUNEL assay, respectively. Sixty rats were provided one of two diets (corn oil or fish oil) and dextran sodium sulfate (DSS, an inducer of oxidative DNA damage) treatments (no DSS, 3% DSS, or DSS withdrawal). Fish oil feeding resulted in lower 8-OHdG levels (P = 0.038), higher levels of apoptosis (P = 0.035), and a lower cell proliferative index (P = 0.05) compared with corn oil feeding. In the top third of the crypt, fish oil caused an incremental stimulation of apoptosis with increased DNA damage (P = 0.043), whereas there was no such relationship with corn oil. Because polyps and tumors develop from DNA damage that leads to loss of growth and death control, the significant difference in fish oil vs. corn oil on these variables may account, in part, for the observed protective effect of fish oil against oxidatively induced colon cancer.
In vivo quantification and parametric images of the cardiac beta-adrenergic receptor density.

UNLABELLED Previous studies showed that the in vivo concentration of beta-adrenergic receptor sites can be estimated by PET using (-)-4-((S)-3-tert-butylamino-2-hydroxypropoxy)-1,3-dihydrobenzoimidazol-2-one (CGP 12177), a hydrophilic ligand. A graphic method was previously proposed and used by several groups. However, this approach was not completely validated. The purpose of this study was to improve and confirm the validity of this approach through a better knowledge of the associated ligand-receptor model, estimated for the first time using the multiinjection approach. METHODS The concentration of beta-adrenergic receptor sites was estimated for mini pigs using 2 methods. The first was the usual multiinjection approach, which permits estimation of all model parameters, including receptor concentration. However, this approach needs a complex protocol, including blood sampling, thereby making it difficult to use for studies on patients. The second method was the CGP 12177 graphic method. This approach permits the estimation of only receptor concentration but has the advantage of not requiring blood sampling. Another advantage is the ability to generate parametric images easily. RESULTS Using the multiinjection approach, we obtained for the first time a complete model describing interactions between CGP 12177 and beta-adrenergic receptors. Knowledge of all parameters of this model permitted good validation of the assumptions included in the graphic method. The concentration of beta-adrenergic receptor sites in mini pigs was estimated at 15.2 +/- 3.4 pmol/mL. CONCLUSION The graphic method has been improved by taking into account various phenomena, such as protein binding and the nonlinearity between plasma concentration and injected dose. This method is now usable for patient studies and offers the ability to estimate the beta-adrenergic receptor concentration from a single PET experiment without blood sampling. Parametric imaging will enable screening of the receptor site location and observation of potential anomalies in patients.
Electrified free-surface flow of an inviscid liquid past topography

The flow of an electrified liquid layer moving over a prescribed topography is studied with the aim of determining the shape of the free surface. The steady flow is assumed to be inviscid, incompressible, and irrotational. The liquid is assumed to act as a perfect conductor and the air above the layer is assumed to act as a perfect dielectric. The electric field is produced by placing one or more charged electrodes at a distance above the free surface. A weakly nonlinear one-dimensional analysis is used to classify the possible solutions and nonlinear solutions are obtained numerically by boundary integral equation methods. It is found that the shape of the liquid layer's surface can be manipulated (using charged electrodes) to become wave-free.
On the Preparata-like codes 1

A class of Preparata-like group codes is considered. It was suggested by Baker, van Lint and Wilson and re-stated in a different form by Ericson. We show that all such codes are inside the Hamming code providing its partition into the cosets of the Preparata-like codes. This partition induces 2-resolvable Steiner quadruple systems.