Miracle-dz/UniFAR-FTUs huggingface dataset:
Ratio of total sulfur amino acids to lysine for finishing pigs.

We conducted two experiments to determine the optimum ratio of total sulfur amino acids (TSAA) to Lys for late finishing pigs. In Exp. 1, 50 barrows and 50 gilts were allotted to treatments with three replicates of three or four pigs per replicate in a randomized complete block (RCB) design within a split-plot arrangement of treatments. Sex was the whole plot and TSAA:Lys ratio was the subplot. Average initial and final BW were 77 and 111 kg. Barrows and gilts were fed diets formulated to contain . 55 and . 65% Lys, respectively. The ratios of TSAA:Lys were . 50, . 55, . 60, . 65, and . 70. Diets met or exceeded an ideal amino acid pattern for all indispensable amino acids (except TSAA), and all diets were isonitrogenous and equal in electrolyte balance. In Exp. 2, 60 gilts were allotted to five treatments with four replicates of three gilts each in a RCB design. Average initial and final BW were 74 and 110 kg. Gilts were fed diets formulated to contain . 65% Lys. The ratios of TSAA:Lys were . 35, . 425, . 50, . 575, and . 65. In Exp. 1, there were no TSAA:Lys ratio effects (P > .10) for ADG, final BW, percentage muscle, longissimus muscle area, carcass length, percentage fat-free lean (PFFLEAN), lean gain per day (LGD), total fat (TOFAT), percentage TOFAT (PTOFAT), fat gain per day (FGD), lean:fat, retained energy in TOFAT as ether extractable lipid (RE-F), retained energy (RE), or serum urea N (SUN). Feed intake (ADFI) was greater (quadratic, P < .05) for pigs fed . 70 TSAA:Lys than for pigs fed any other treatment. Hot carcass weight, psoas muscle weight, 10th rib fat thickness, dressing percentage, fat-free lean (FFLEAN), and retained energy in FFLEAN as protein (RE-P) responded inconsistently to TSAA:Lys ratio, resulting in cubic (P < .09) effects. In Exp. 2, ADFI (linear, P < .08), TOFAT (linear, P < .05), PTOFAT (linear, P < .07), FGD (linear, P < .05), RE-F (linear, P < .05), RE (linear, P < .05), and SUN (linear, P < .02; quadratic, P < .01) decreased as TSAA:Lys ratio increased. Also, gain:feed (GF) (linear, P < .01; quadratic, P < .04), PFFLEAN (linear, P < .04), and lean:fat (linear, P < .04) increased as TSAA:Lys ratio increased. One-slope, broken-line regression models estimated required ratios of TSAA:Lys of . 44 (SUN), . 40 (ADG), . 47 (ADFI), . 45 (GF), . 45 (FFLEAN), . 44 (LGD), . 65 (TOFAT), . 65 (FGD), . 44 (RE-P), . 65 (RE-F), . 65 (RE), and . 57 (lean:fat). Thus, for growth and muscling traits of late finishing pigs, the optimum ratio of TSAA:Lys is less than the current proposed ratio (.65), but to minimize fat accretion, the ratio is . 65.
Rural urban differences of cardiovascular disease risk factors in adult Asian Indians

The prevalence of cardiovascular disease (CVD) risk factors in “People of Indian Origin” (PIO) is exceedingly high and strong relationships among elevated blood pressure, increased levels of lipoproteins, visceral obesity, physical inactivity and subsequent high occurrence of coronary heart disease, type 2 diabetes mellitus etc., were evident in many studies. Increasing urbanization with effective changes in lifestyles could be attributed to explain this exaggerated rate. The present community based cross‐sectional investigation was aimed to identify rural‐urban differences in prevalence of risk factors of CVD in the adult Asian Indians. A total of 350 adult (30 years and above) individuals (184 males and 166 females) belong to urban (n = 193, males = 104, and females = 89) and rural (n = 157, males = 80, and females = 77) areas participated in the study. Anthropometric measures, lipids profiles, fasting blood glucose and blood pressure measures were obtained from participants. The mean body mass index (kg/m2) for male and female was 22.37 ± 4.09 and 23.20 ± 4.37, respectively. There existed significant differences for anthropometric, metabolic, and blood pressure variables between rural and urban areas. Habitat (rural vs. urban) had significant impact on central adiposity, lipids, lipoproteins, and blood pressure measures even after adjusted for age and sex. Overall, 84.3% of females had lower HDL level compared with only 20.1% in males. It was also observed that the prevalence of metabolic syndrome was 56.2% in urban females compared with 36.4% in rural females. Effective urbanization and or modernization seem to influence CVD risk factors and warrants intervention as early as adulthood to check this menace. Am. J. Hum. Biol., 2008. © 2008 Wiley‐Liss, Inc.
Gearbox monitoring by using the stray flux in an induction machine based electromechanical system

The aim of this paper is to analyze experimentally the stray flux spectrum of a three phase induction machine in an electromechanical system, in order to show how it is influenced by the gearbox behavior. The mechanical monitoring in the electromechanical systems has been mainly studied using vibration signals. Recently, some works have been performed in order to monitor the mechanical part by using the stator current spectrum. In this paper the effect of the gearbox behavior is observed in the stray flux by using the spectral signature given by the stator current which is produced by the torsional vibrations induced by the gearbox in normal operation. This study is performed on two different induction machines (squirrel-cage and wound rotor) sharing the same mechanical system.
Antiapoptotic potential of herbal drugs in cardiovascular disorders: An overview

Cardiomyocyte apoptosis has been reported in a number of cardiovascular disorders, including myocardial infarction, ischemia–reperfusion, end-stage heart failure, arrhythmogenic right ventricular dysplasia, and adriamycin-induced cardiomyopathy. Prevention of myocyte apoptosis has emerged as a potential new target in a multimodel therapeutic approach to cardiac disease. Herbal therapy may be an alternative strategy for the prevention and treatment of heart disease. The present review summarizes the list of plants/herbal formulations studied for their antiapoptotic activity in cardiovascular disorders. However, despite extensive positive research data from experimental studies for herbal drugs in cardiovascular disorders, and the anecdotal clinical experience of many practitioners and patients, its potential in the field of cardiac apoptosis remains largely untapped, and large scale clinical trials are needed to explore the potential of herbal medicines as a new treatment regime for targeting cardiovascular apoptosis.
Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial.

CONTEXT Docosahexaenoic acid (DHA) is the most abundant long-chain polyunsaturated fatty acid in the brain. Epidemiological studies suggest that consumption of DHA is associated with a reduced incidence of Alzheimer disease. Animal studies demonstrate that oral intake of DHA reduces Alzheimer-like brain pathology. OBJECTIVE To determine if supplementation with DHA slows cognitive and functional decline in individuals with Alzheimer disease. DESIGN, SETTING, AND PATIENTS A randomized, double-blind, placebo-controlled trial of DHA supplementation in individuals with mild to moderate Alzheimer disease (Mini-Mental State Examination scores, 14-26) was conducted between November 2007 and May 2009 at 51 US clinical research sites of the Alzheimer's Disease Cooperative Study. INTERVENTION Participants were randomly assigned to algal DHA at a dose of 2 g/d or to identical placebo (60% were assigned to DHA and 40% were assigned to placebo). Duration of treatment was 18 months. MAIN OUTCOME MEASURES Change in the cognitive subscale of the Alzheimer's Disease Assessment Scale (ADAS-cog) and change in the Clinical Dementia Rating (CDR) sum of boxes. Rate of brain atrophy was also determined by volumetric magnetic resonance imaging in a subsample of participants (n = 102). RESULTS A total of 402 individuals were randomized and a total of 295 participants completed the trial while taking study medication (DHA: 171; placebo: 124). Supplementation with DHA had no beneficial effect on rate of change on ADAS-cog score, which increased by a mean of 7.98 points (95% confidence interval [CI], 6.51-9.45 points) for the DHA group during 18 months vs 8.27 points (95% CI, 6.72-9.82 points) for the placebo group (linear mixed-effects model: P = .41). The CDR sum of boxes score increased by 2.87 points (95% CI, 2.44-3.30 points) for the DHA group during 18 months compared with 2.93 points (95% CI, 2.44-3.42 points) for the placebo group (linear mixed-effects model: P = .68). In the subpopulation of participants (DHA: 53; placebo: 49), the rate of brain atrophy was not affected by treatment with DHA. Individuals in the DHA group had a mean decline in total brain volume of 24.7 cm(3) (95% CI, 21.4-28.0 cm(3)) during 18 months and a 1.32% (95% CI, 1.14%-1.50%) volume decline per year compared with 24.0 cm(3) (95% CI, 20-28 cm(3)) for the placebo group during 18 months and a 1.29% (95% CI, 1.07%-1.51%) volume decline per year (P = .79). CONCLUSION Supplementation with DHA compared with placebo did not slow the rate of cognitive and functional decline in patients with mild to moderate Alzheimer disease. TRIAL REGISTRATION clinicaltrials.gov Identifier: NCT00440050.
Identification and validation of mixed anxiety–depression

Background. Mixed anxiety–depression (MAD) has been under scrutiny to determine its potential place in psychiatric nosology. The current study sought to investigate its prevalence, clinical characteristics, course and potential validators. Method. Restricted latent-class analyses were fit to 12-month self-reports of depression and anxiety symptom criteria in a large population-based sample of twins. Classes were examined across an array of relevant indicators (demographics, co-morbidity, adverse life events, clinical significance and twin concordance). Longitudinal analyses investigated the stability of, and transitions between, these classes for two time periods approximately 1.5 years apart. Results. In all analyses, a class exhibiting levels of MAD symptomatology distinctly above the unaffected subjects yet having low prevalence of either major depression (MD) or generalized anxiety disorder (GAD) was identified. A restricted four-class model, constraining two classes to have no prior disorder history to distinguish residual or recurrent symptoms from new onsets in the last year, provided an interpretable classification: two groups with no prior history that were unaffected or had MAD and two with prior history having relatively low or high symptom levels. Prevalence of MAD was substantial (9–11%), and subjects with MAD differed quantitatively but not qualitatively from those with lifetime MD or GAD across the clinical validators examined. Conclusions. Our findings suggest that MAD is a commonly occurring, identifiable syndromal subtype that warrants further study and consideration for inclusion in future nosologic systems.
In‐Depth Analysis of Hyaline Fibromatosis Syndrome Frameshift Mutations at the Same Site Reveal the Necessity of Personalized Therapy

Hyaline fibromatosis syndrome is an autosomal recessive disease caused by mutations in ANTXR2, a gene involved in extracellular matrix homeostasis. Sixty percent of patients carry frameshift mutations at a mutational hotspot in exon 13. We show in patient cells that these mutations lead to low ANTXR2 mRNA and undetectable protein levels. Ectopic expression of the proteins encoded by the mutated genes reveals that a two base insertion leads to the synthesis of a protein that is rapidly targeted to the ER‐associated degradation pathway due to the modified structure of the cytosolic tail, which instead of being hydrophilic and highly disordered as in wild type ANTXR2, is folded and exposes hydrophobic patches. In contrast, one base insertion leads to a truncated protein that properly localizes to the plasma membrane and retains partial function. We next show that targeting the nonsense mediated mRNA decay pathway in patient cells leads to a rescue of ANTXR2 protein in patients carrying one base insertion but not in those carrying two base insertions. This study highlights the importance of in‐depth analysis of the molecular consequences of specific patient mutations, which even when they occur at the same site can have drastically different consequences.
Measurement-based stochastic models for channel transition in underground subway environments

In this contribution, a recently conducted measurement campaign in underground subway environments is introduced. The downlink signals in an in-service UMTS network are collected in the subway carriage by using an Universal Software-defined Radio Peripheral (USRP) equipment and used to extract the channel impulse responses (CIRs) between a user equipment and UMTS stations. A high-resolution parameter estimation algorithm derived based on the SAGE principle is applied to estimate the delays, Doppler frequencies and complex attenuations of multiple propagation paths from the CIRs. Based on the multipath parameter estimates, the composite delay and Doppler frequency spreads are calculated. Significant transitions are observed for the channels when the subway increases its speed moving from a platform to a tunnel. The statistics of the time-variations of the aforementioned parameters during the transitions are extracted which constitute a stochastic model for channel transitions in underground subway environments.
Guinea Pig Allergy Tests: an Overview

Allergenicity testing is needed to reduce the hazard of occupational and consumer exposure to new chemicals and products which may come in contact with the skin. The magnitude of the contact allergy problem is seen in epidemiological investigations, which have shown different figures due to variations in methodology. Skin diseases make up about half of the reported industrial diseases in the United States, and contact dermatitis was the most prevalent diagnosis, accounting for 32% of dermatological occupational diseases in New York (Johnson et al., 1979). In Denmark, 7% of patients seeking outpatient dermatological care had contact dermatitis (Christoffersen, 1984). Topical drugs and cosmetics were frequent causes of allergic contact dermatitis (Andersen and Maibach, 1983; Rudzki and Zakrzewski, 1975). However, dermatological studies underestimate the frequency of adverse reactions from cosmetics, because most problems are solved by consumers themselves by discontinuing the use of a product or by other trial-and-error methods (Eiermann et al., 1982).
Veltuzumab (humanized anti-CD20 monoclonal antibody): characterization, current clinical results, and future prospects

Veltuzumab is a humanized, anti-CD20 monoclonal IgG1 antibody (MAb), constructed recombinantly on the framework regions of epratuzumab, with complementarity-determining regions (CDRs) identical to rituximab, except for a single amino acid in CDR3 of the variable heavy chain. Veltuzumab showed anti-proliferative, apoptotic, and antibody-dependent cellular cytotoxicity effects in vitro similar to rituximab, but with significantly slower off-rates and increased complement-dependent cytotoxicity in several human lymphoma cell lines. In addition, very low doses of veltuzumab, given either intravenously or subcutaneously, depleted B cells in normal cynomolgus monkeys, and controlled tumor growth in mice bearing human lymphomas. Clinically, veltuzumab has been studied in > 150 patients with lymphomas and autoimmune diseases. In non-Hodgkin lymphoma (NHL), infusions of 80–750 mg/m2 were well tolerated when given once-weekly for four doses, with the only toxicity being transient mild–moderate infusion reactions. Objective tumor responses, including durable complete responses, occurred at all dose levels. Subcutaneous injections of low doses (80–320 mg) have also proved to be safe and pharmacologically active, producing objective responses, including durable complete responses, at rates comparable to those reported with rituximab, in patients with NHL and immune thrombocytopenia.
Procarbazine carcinogenicity in methotrexate-treated or lipotrope-deficient male rats.

Procarbazine hydrochloride (PCZ), a chemotherapeutic agent used extensively to treat Hodgkins disease and other tumors, induces leukemia, lymphoma, mammary gland and other solid tumors in rodents and non-human primates and is strongly implicated as a leukemogen in humans. Lipotrope (choline and methionine) deficiency is a powerful potentiator of chemical carcinogenesis in liver and, under some conditions, in other tissues in rodents. Methotrexate (MTX), another commonly used chemotherapeutic agent, interferes with one-carbon metabolism and limits availability of lipotropes. Studies of PCZ carcinogenesis in lipotrope-deficient or MTX-treated male rats are reported, showing that both deficiency and MTX increased PCZ carcinogenicity in the mammary gland. In addition, PCZ was found to induce abnormalities of hepatic choline metabolism. Weanling male Sprague-Dawley rats were fed control (C) or lipotrope-deficient (D) diet. After 3 weeks, C and D rats were given PCZ, MTX, the two drugs together or 0.9% saline by i.p. injection. Doses were 0.2 or 0.5 mg MTX/kg or 25 mg PCZ/kg, given 2 or 3 days per week for 5 or 14 weeks. After 5 weeks of drug treatment livers were assayed for choline, phosphatidylcholine, phosphocholine (PCho), glycerophosphocholine and betaine. PCZ perturbed choline metabolism, increasing hepatic choline and PCho in deficient or MTX-treated rats and, to a smaller extent, in rats fed control diet. MTX markedly enhanced the effect of PCZ on choline metabolism. PCZ-induced mammary tumor incidence was increased 50-70% by lipotrope deficiency or by MTX. In PCZ-treated rats, cumulative probability of bearing a mammary tumor was significantly increased by lipotrope deficiency (P = 0.05), and was increased similarly but not significantly by MTX (P = 0.1). Cumulative tumor numbers per group in PCZ-treated rats were significantly greater in both deficient and MTX-treated rats compared to rats fed control diet (P less than 0.005). Incidences of leukemia, lymphoma and Zymbal's gland tumors induced by PCZ were not significantly altered by diet or MTX.
The relationship between self-regulatory efficacy and writing achievement in English

The thesis study aims to explore whether students‟ writing self-regulatory efficacy contributes to their writing achievement in English, investigating the probable relationship between these components. In addition, it is aimed to examine whether students‟ department, gender and type of high school they graduated have a role in their writing self-regulatory efficacy and writing achievement in English. This study was designed as a quantitative research. The participants of the study were 171 Preparatory Class students of English Translation and Interpretation (ETI) and English Language Teaching (ELT) Departments at The School of Foreign Languages, Trakya University in 2011-2012 Academic Year. In the study, The Writing Self-Regulatory Efficacy Scale by Zimmerman and Bandura (1994) was used as the data collection instrument to assess students‟ writing self-regulatory efficacy. Students‟ writing achievement was determined by their end-of-the-year grades in Writing Course. The data gathered was statistically analyzed by SPSS 17.0. According to the results, Preparatory Class students of ETI and ELT Departments at Trakya University were observed to be moderately efficacious in regulating their writing process. Moreover, a moderate positive relationship, which was statistically significant, was revealed between students‟ writing self-regulatory efficacy and their writing achievement in English. This result indicated that writing achievement is related to writing self-regulatory efficacy, and students with higher writing selfregulatory efficacy tend to have better writing achievement. However, no significant difference was found in students‟ writing self-regulatory efficacy and writing achievement in terms of their gender, department and type of high school. Thus, this study highlighted the significance of writing self-regulatory efficacy for writing achievement in English, displaying the positive relationship between these elements.
The role of intracavernosal injection therapy and the reasons of withdrawal from therapy in patients with erectile dysfunction in the era of PDE5 inhibitors

There has been little data regarding the role of intracavernosal injection (ICI) treatment, its discontinuation rate and the reasons of withdrawal in patients with erectile dysfunction (ED) in the era of phosphodiesterase type 5 (PDE5) inhibitors. The aim of this study was to investigate the rate of withdrawal and its associated reasons in patients undergoing ICI therapy. Patients who were prescribed with ICI treatment two times or more were included since the introduction of sildenafil in Korea in 1999. Telephone surveys were performed to evaluate intercourse rates, withdrawal rates and their associated reasons, adverse events and the patients' satisfaction with their sex lives after the ICI treatments. Two hundred and ninety‐four men were contacted by telephone. The mean age was 61.8 ± 7.9 years with a follow‐up duration of 25.6 ± 32.1 months. At the last follow‐up, 79.9% had discontinued the treatment. Most patients had previously failed PDE5 inhibitor treatment prior to the ICI therapy, and more than half had two or more risk factors of ED. Adequate penile rigidity after ICI therapy was restored in 60.2% of patients. The reasons for discontinuation of ICI were poor response (43.1%), inconvenience of use (18.3%), switch to other treatments (10.7%), loss of libido (6.7%), adverse events (5.5%) and return of spontaneous erection (2.8%). Pain was the most common adverse event in the withdrawal group, whereas prolonged erection was most common in the continuing group. Following ICI treatment, PDE5 inhibitors were the most common therapeutic option (63.1%). The overall satisfaction rate regarding sex life was significantly high in the treatment‐continuing group. In conclusion, patients on ICI treatment had severe ED and high withdrawal rates in the era of PDE5 inhibitors. The most common reason for treatment discontinuation was poor response. Before initiating ICI treatments, sufficient counselling is necessary.
Gliadin, endomysial and thyroid antibodies in patients with latent autoimmune diabetes of adults (LADA)

Latent autoimmune diabetes of adults (LADA) manifested after the age of 35 is characterized by the presence of disease‐specific autoantibodies (anti‐glutamate decarboxylase GADAb, anti‐IA2Ab). However, autoimmunity in Type 1 diabetes mellitus is not targeted only to pancreatic beta‐cells. No data have so far been published concerning the antibodies associated with other autoimmune disease in LADA patients. The presence of anti‐thyroglobulin (TGAb), anti‐thyroid peroxidase (TPOAb), anti‐gliadin IgA (AGAAb) and IgG (AGGAb) and endomysial antibodies (EMAb) in sera of 68 diabetics typed as LADA was compared with the antibody presence in sera of 85 patients with Type 2 diabetes. We found a significantly higher occurrence of gliadin antibodies in LADA patients: the rate of AGGAb was 19·1% in comparison with 3·5% in the T2DM group (P = 0·0026), the rate of AGAAb was 13·2% in comparison with 3·5% (P = 0·035). The prevalence of EMAb was very low in both groups (1·5% and 0). The two groups differed significantly in the TPOAb rate: 22·1% in LADA compared to 9·4% in T2DM (P = 0·04), whereas no significant difference was found in the presence of TGAb (8·8% and 3·5%, P = 0·187). In comparison with T2DM patients, LADA patients were found to express higher antibody activity against gluten‐related antigens and against TPO.