Miracle-dz/UniFAR-FTUs huggingface dataset:
Do sex or race differences influence strength training effects on muscle or fat?

PURPOSE To examine the influence of sex and race on the effects of strength training (ST) on thigh muscle volume (MV), midthigh subcutaneous fat (SCF), and intermuscular fat (IMF). METHODS One hundred eighty-one previously inactive healthy Caucasian (N = 117) and African American (N = 54) men (N = 82) and women (N = 99), aged 50-85 yr, underwent about 10 wk of unilateral knee extension ST. Ten subjects were neither Caucasian nor African American and were, therefore, not included in the race analysis. Quadriceps MV and midthigh SCF and IMF cross-sectional area were measured with computed tomography before and after ST. Sex and race comparisons were made with a 2 x 2 (sex by race) analysis of covariance. RESULTS Training-induced increases in absolute MV were significantly greater (P < 0.001) in men than in women, though both sex groups increased MV significantly with ST (P < 0.001), and the relative (%) increases were similar. There were significant increases in MV within race groups (P < 0.001), but no significant differences between races. There were no significant changes in SCF or IMF, whether sex and racial groups were separated or combined. In addition, there was no sex by race interaction for changes in MV, SCF, or IMF with ST. CONCLUSION Strength training does not alter subcutaneous or intermuscular fat, regardless of sex or racial differences. Although men exhibit a greater muscle hypertrophic response to strength training than do women, the difference is small. Race does not influence this response.
Pathologic and biochemical studies of juvenile parkinsonism linked to chromosome 6q

We report the results of pathologic and biochemical studies in a patient with 6q-linked autosomal recessive juvenile parkinsonism (AR-JP). Neuronal loss and gliosis were restricted to the substantia nigra and the locus ceruleus. No Lewy bodies were found, but neurofibrillary tangles and argyrophilic astrocytes were seen in the cerebral cortex and brainstem nuclei. The later findings, which have not been reported previously in AR-JP, suggest the pathologic heterogeneity of 6q-linked AR-JP.
Review of varicella zoster seroepidemiology in India and South‐east Asia

Summary Varicella zoster virus (VZV) predominantly affects children in temperate countries, with near‐universal seroconversion occurring by late childhood. However, in tropical regions, VZV infection is common in adolescents and adults. This review identifies age‐related VZV seroprevalence patterns in a number of Asian countries which indicate that seroconversion in tropical countries occurs at a later age than in temperate countries. Seasonal and regional variations in acute disease within some Asian countries suggest that temperate climates might favour transmission of the varicella virus, with incidence peaking during cooler months and in cooler, more temperate regions. VZV infection is often more severe in adults than in children, suggesting that tropical countries may be at risk of greater morbidity and mortality as a result of later‐age seroconversion. Susceptibility of pregnant women and their infants, and of people infected with HIV/AIDS is also cause for concern. Vaccination may be beneficial in reducing the impact of VZV in Asian populations.
Air pollution and emergency admissions in Boston, MA

Study Objective: Many studies have shown that ambient particulate air pollution (PM) is associated with increased risk of hospital admissions and deaths for cardiovascular or respiratory causes around the world. In general these have been analysed in association with PM10 and ozone, whereas PM2.5 is now the particle measure of greatest health and regulatory concern. And little has been published on associations of hospital admissions and PM components. Design: This study analysed hospital admissions for myocardial infarction (15 578 patients), and pneumonia (24 857 patients) in associations with fine particulate air pollution, black carbon (BC), ozone, nitrogen dioxide (NO2), PM not from traffic, and carbon monoxide (CO) in the greater Boston area for the years 1995–1999 using a case-crossover analysis, with control days matched on temperature. Main results: A significant association was found between NO2 (12.7% change (95% CI: 5.8, 18)), PM2.5 (8.6% increase (95% CI: 1.2, 15.4)), and BC (8.3% increase (95% CI: 0.2, 15.8)) and the risk of emergency myocardial infarction hospitalisation; and between BC (11.7% increase (95% CI: 4.8, 17.4)), PM2.5 (6.5% increase (95% CI: 1.1, 11.4)), and CO (5.5% increase (95% CI: 1.1, 9.5)) and the risk of pneumonia hospitalisation. Conclusions: The pattern of associations seen for myocardial infarction and pneumonia (strongest associations with NO2, CO, and BC) suggests that traffic exposure is primarily responsible for the association with heart attacks.
Caring for children with disabilities in a foreign land: Experiences and perceptions of a group of Korean parents and professionals

INTRODUCTION: This article aims to provide an overview of the experiences of Korean immigrant parents raising children with disabilities in Aotearoa New Zealand, primarily focusing on their experience of disability services and systems. METHODS: As the present exploratory study aimed to gain a deeper understanding of immigrant parents’ experiences and perceptions, a qualitative approach was employed to collect rich and lived information from participants. Ten participants were recruited and interviewed among Korean parents of children with disabilities and professionals working with those families. FINDINGS: Lack of trust among Korean parents living in Aotearoa New Zealand was frequently discussed by the participants in the present study. Lack of information around available services and alternative support and cultural barriers were often identified to have a significant impact on Korean parents’ experiences with services. A sense of obligation to integrate into the host society and the services provided was also evident. Further, there was a contradictory perception between parents and associated professionals in relation to services’ expectations of Korean parents. CONCLUSIONS: From analysis of the findings, three main themes emerged: experiences of services and its relations with trust, cultural values and expectations, and looking to the future. The study suggests that there is a need for professionals, service providers and government to consider ways to build trusting relationships with Korean parents and their children with disabilities, and makes a number of recommendations.
Airy point process at the liquid-gas boundary

Domino tilings of the two-periodic Aztec diamond feature all of the three possible types of phases of random tiling models. These phases are determined by the decay of correlations between dominoes and are generally known as solid, liquid and gas. The liquid-solid boundary is easy to define microscopically and is known in many models to be described by the Airy process in the limit of a large random tiling. The liquid-gas boundary has no obvious microscopic description. Using the height function we define a random measure in the two-periodic Aztec diamond designed to detect the long range correlations visible at the liquid-gas boundary. We prove that this random measure converges to the extended Airy point process. This indicates that, in a sense, the liquid-gas boundary should also be described by the Airy process.
Fruit and Vegetable By-Products to Fortify Spreadable Cheese

In this work, spreadable cheese was enriched with flours from by-products (red and white grape pomace, tomato peel, broccoli, corn bran, and artichokes) as sources of fibres and antioxidant compounds. The physicochemical and the sensory properties of all the cheese samples were analysed. Results revealed that total phenolic content, flavonoids, and antioxidant activity of samples containing grape pomace significantly increased, followed by broccoli, artichoke, corn bran, and tomato peel by-products, compared to the control cheese. Specifically, cheeses containing white and red grape pomace recorded high phenolic content (2.74 ± 0.04 and 2.34 ± 0.15 mg GAEs/g dw, respectively) compared to the control (0.66 mg GAEs/g dw).
Agriscience Education Through Inquiry-Based Learning: Investigating Factors that Influence the Science Competence of Middle School Students

Inquiry-based teaching methods have been found to enhance students’ abilities to understand the process of scientific inquiry. The purpose of this study was to determine if middle school students taught through an inquiry-based teaching approach consisting of scientific skill development, scientific knowledge, and scientific reasoning were more likely to meet their respective science grade level expectation. Participants consisted of predominantly Hispanic sixth and eighth grade students enrolled in school enrichment programs through the MMSAEEC. Inquiry-based instruction was integrated within science classes using lessons in soil pH and water quality. Overall, sixth grade students scored highest on items related to science skill, while the eighth grade students scored highest on the science knowledge portion of the instrument. Regarding the sixth grade students, science reasoning and science skill were found to be significant predictors of grade level expectation, while science skill was significant for the eighth grade data. It is recommended that teachers incorporate inquiry-based learning strategies into their classrooms to encourage students to ask questions and refine their ability to think critically and solve problems. Further research is needed to clarify the role of science comprehension and the associated sub-dimensions with the ability to predict grade level expectation.
Water molecule reorganization in cytochrome c oxidase revealed by FTIR spectroscopy

Although internal electron transfer and oxygen reduction chemistry in cytochrome c oxidase are fairly well understood, the associated groups and pathways that couple these processes to gated proton translocation across the membrane remain unclear. Several possible pathways have been identified from crystallographic structural models; these involve hydrophilic residues in combination with structured waters that might reorganize to form transient proton transfer pathways during the catalytic cycle. To date, however, comparisons of atomic structures of different oxidases in different redox or ligation states have not provided a consistent answer as to which pathways are operative or the details of their dynamic changes during catalysis. In order to provide an experimental means to address this issue, FTIR spectroscopy in the 3,560–3,800 cm-1 range has been used to detect weakly H-bonded water molecules in bovine cytochrome c oxidase that might change during catalysis. Full redox spectra exhibited at least four signals at 3,674(+), 3,638(+), 3,620(−), and 3,607(+) cm-1. A more complex set of signals was observed in spectra of photolysis of the ferrous-CO compound, a reaction that mimics the catalytic oxygen binding step, and their D2O and H218O sensitivities confirmed that they arose from water molecule rearrangements. Fitting with Gaussian components indicated the involvement of up to eight waters in the photolysis transition. Similar signals were also observed in photolysis spectra of the ferrous-CO compound of bacterial CcO from Paracoccus denitrificans. Such water changes are discussed in relation to roles in hydrophilic channels and proton/electron coupling mechanism.
Hippocampal and amygdalar volumes in psychotic and nonpsychotic unipolar depression.

OBJECTIVE The limbic system is thought to underlie dysfunctional affective and cognitive processes in individuals with depression. Neuroanatomical studies of subjects with depression have often examined hippocampal and amygdalar structures, since they are two key structures of the limbic system. Research has often but not always found reduced hippocampal volume in patients with major depression. The purpose of the present study was to examine differences in hippocampal and amygdalar volumes in patients with depression subtypes relative to healthy comparison subjects. METHOD Participants were 1) patients with major depression with psychosis, 2) patients with major depression without psychosis, and 3) healthy comparison subjects. To examine hippocampal and amygdalar volumes, all participants underwent structural magnetic resonance imaging (MRI). The authors further examined the effects of clinical and chronicity data on these two brain structures. RESULTS After age, gender, and total brain volume were controlled, depressed patients with psychosis had a significantly smaller mean amygdala volume relative to depressed patients without psychosis and healthy comparison subjects. There were no differences between depressed patients without psychosis and healthy comparison subjects. Correlational analyses suggested that age of depression onset was strongly associated with amygdala volume. No group differences in hippocampal volume were found. CONCLUSIONS There were no differences between depressed patients and healthy comparison subjects in hippocampal volume. However, psychotic but not nonpsychotic depression was associated with reduced amygdala volume. Reduced amygdala volume was not associated with severity of depression or severity of psychosis but was associated with age at onset of depression. Smaller amygdala volume may be a risk factor for later development of psychotic depression. In addition, chronicity of depression and depression subtype might be two important factors associated with hippocampal and amygdalar volumes in depression.
Overview of obesity in Mainland China

This overview describes the study of obesity issues over the last 8 years in Mainland China. A disease risk‐based body mass index classification for Chinese adults was developed and verified by the results of the 2002 China Nationwide Nutrition and Health Survey. Age and gender‐specific BMI cut‐offs for Chinese children and adolescents aged 7–18 years were also developed. As the first step in the obesity control effort, the public health implications of the prevalence of overweight and obesity were set out and publicized by the government of China. The overweight prevalence in 2002 was 22.8% and for obesity 7.1%, these having increased by 40.7% and 97.2%, respectively, since 1992. In children, dramatic increases in overweight/obesity have occurred with a two‐ to threefold increase in Beijing and Shanghai between 1985 and 1995; the prevalence of overweight plus obesity in 7‐ to 12‐year‐old boys approached 29% in 2000 and in girls 15–17%. The rapid development of overweight/obesity in China will undoubtedly push up the prevalence of chronic disease. The relative risk for adult hypertension and diabetes in the overweight and obese populations was 2–5 in 2002. In adolescents, the relative risk of hypertension in the overweight was 3.3 and in the obese 3.9, with a clustering of cardiovascular risk factors in the obese Chinese children of whom 90.5% had evidence of abdominal obesity. Even the overweight group had 15.8% with abdominal obesity. Based on the population attributable risks of overweight and obesity in 2002 and data on the direct medical costs of hypertension, diabetes, stroke and coronary heart disease, 25% of these comorbidity costs could be attributed to overweight and obesity. As the improvement in linear growth of young children is usually slower than their improvements in weight during the economic development of China, the long‐term adult implications of having a problem of ‘Stunted obesity’ rather than simple obesity in young children are raised. Analysis of the associations between adult obesity with the individuals' fetal and early nutrition highlights the need for further investigation.
Early posttransplant hepatic venous outflow obstruction: Long‐term efficacy of primary stent placement

Although balloon angioplasty has been accepted as the safe and effective initial treatment to manage hepatic venous outflow abnormalities, it may induce rupture of the fresh anastomosis but also may be ineffective to eliminate various etiologies of venous outflow abnormalities in the early post‐transplant period. Therefore, we performed primary stent placement in 108 patients to treat early‐onset (≤4 weeks) post‐transplant hepatic venous outflow abnormality. The following parameters were documented retrospectively: technical success and complications: clinical success; recurrence; and patency of stent‐inserted hepatic veins.
Tobacco Cessation Scenarios Among Healthcare Profession Students: A Multidisciplinary Study

Background: It is acknowledged that the most effective means to contain the tobacco epidemic is to involve healthcare providers across various disciplines. The present study was undertaken to gain a comprehensive insight into various factors that determine the efficacy of multidisciplinary approaches in tobacco control. Methods: A cross sectional study design using a structured, pretested and self-administered questionnaire was employed in the present study, conducted among medical and dental interns and final year nursing students. Respondent demographics, knowledge, attitude, behaviour, perceived effectiveness and barriers, and willingness to participate in tobacco cessation were assessed. Results: A total of 268 subjects participated, with mean knowledge, attitude, behaviour, perceived effectiveness and barrier scores of 69. 7%, 89.0%, 72.0%, 80.6% and 88.6% respectively. There were significant differences among the mean scores of the study domains across the 3 disciplines. The majority (92.91%) of the respondents were willing to participate in tobacco cessation activities, but only 14.2% had previously received relevant training. Regression analysis revealed that the significant predictors of behaviour scores were gender, course, attitude and perceived effectiveness; those for willingness to undertake tobacco cessation activities were course, attitude, behaviour and perceived barriers. Conclusions: The study highlighted the willingness but low previous training among the participants and also identified factors that determine t behaviour and willingness to undertake tobacco cessation activities. The study emphasizes the need for modification in the policies pertaining to curricula of medical, dental and nursing training programs.
Restriction of Viral Replication by Mutation of the Influenza Virus Matrix Protein

ABSTRACT The matrix protein (M1) of influenza virus plays an essential role in viral assembly and has a variety of functions, including association with influenza virus ribonucleoprotein (RNP). Our previous studies show that the association of M1 with viral RNA and nucleoprotein not only promotes formation of helical RNP but also is required for export of RNP from the nucleus during viral replication. The RNA-binding domains of M1 have been mapped to two independent regions: a zinc finger motif at amino acid positions 148 to 162 and a series of basic amino acids (RKLKR) at amino acid positions 101 to 105, which is also involved in RNP-binding activity. To further understand the role of the RNP-binding domain of M1 in viral assembly and replication, mutations in the coding sequences of RKLKR and the zinc finger motif of M1 were constructed using a PCR technique and introduced into wild-type influenza virus by reverse genetics. Altering the zinc finger motif of M1 only slightly affected viral growth. Substitution of Arg with Ser at position 101 or 105 of RKLKR did not have a major impact on nuclear export of RNP or viral replication. In contrast, deletion of RKLKR or substitution of Lys with Asn at position 102 or 104 of RKLKR resulted in a lethal mutation. These results indicate that the RKLKR domain of M1 protein plays an important role in viral replication.
Neural dynamics underlying emotional transmissions between individuals

Abstract Emotional experiences are frequently shaped by the emotional responses of co-present others. Research has shown that people constantly monitor and adapt to the incoming social–emotional signals, even without face-to-face interaction. And yet, the neural processes underlying such emotional transmissions have not been directly studied. Here, we investigated how the human brain processes emotional cues which arrive from another, co-attending individual. We presented continuous emotional feedback to participants who viewed a movie in the scanner. Participants in the social group (but not in the control group) believed that the feedback was coming from another person who was co-viewing the same movie. We found that social–emotional feedback significantly affected the neural dynamics both in the core affect and in the medial pre-frontal regions. Specifically, the response time-courses in those regions exhibited increased similarity across recipients and increased neural alignment with the timeline of the feedback in the social compared with control group. Taken in conjunction with previous research, this study suggests that emotional cues from others shape the neural dynamics across the whole neural continuum of emotional processing in the brain. Moreover, it demonstrates that interpersonal neural alignment can serve as a neural mechanism through which affective information is conveyed between individuals.
Criticism of neo-colonialism: clarification of Sino-African cooperation and its implication to the west

ABSTRACT This paper examines whether the claims regarding the nature of the Sino-African relations can be qualified or categorised as a neo-colonialism approach. Additionally, the paper analyses the Western perception and implication towards the Sino-African geopolitical cooperation and clarifies whether China is taking advantage of the weak African states in the name of South–South cooperation or playing the role of a contemporary proxy of the old colonial system and re-partitioning Africa. The relation between China and Africa simultaneously presents both challenges and opportunities for either of them. This study argues that the criticism that China is invading the continent and practicing neo-colonialism is just a speculation or Sino-phobia. In fact, the Chinese have no gene in their blood to invade Africa and it is crystal clear that unlike China, the Western world has had an influential history in the African continent. The African government and their societies have the ability to address the issues of Sino-African relations. This paper additionally provides a theoretical analysis of China’s enthusiastic involvement and contribution to the international aid operations and its presence and contribution in Africa.