Miracle-dz/UniFAR-FTUs huggingface dataset:
Robert Working Paper Incentives and the Sorting of Altruistic Agents into Street-Level Bureaucracies

Many street-level bureaucrats (such as caseworkers) have the dual task of helping some clients, while sanctioning others. We develop a model of such a street-level bureaucracy and study the implications of its personnel policy on the self-selection and allocation decisions of agents who differ in altruism towards clients. When bureaucrats are paid flat wages, they do not sanction, and the most altruistic types sort into bureaucracy. Pay-for-performance induces some bureaucrats to sanction, but necessitates an increase in expected wage compensation, which can result in sorting from both the top and bottom of the altruism distribution. We also show how client composition affects sorting and why street-level bureaucrats often experience an overload of clients.
Nitric oxide synthase expression and enzymatic activity in multiple sclerosis

We used post‐mortem magnetic resonance imaging (MRI) guidance to obtain paired biopsies from the brains of four patients with clinical definite multiple sclerosis (MS). Samples were analyzed for the immunoreactivity (IR) of the three nitric oxide (NO) synthase isoforms [inducible, neuronal and endothelial nitric oxide synthase (NOS)], and enzymatic NO synthase activity. MRI guided biopsies documented more active plaques than macroscopic examination, and histological examination revealed further lesions. Inducible NOS (iNOS) was the dominant IR isoform, while reactive astrocytes were the dominant iNOS expressing cells in active lesions. NOS IR expressing cells were widely distributed in plaques, in white and gray matter that appeared normal macroscopically, and on MR. Endothelial NOS (eNOS) was highly expressed in intraparenchymal vascular endothelial cells of MS patients. A control group matched for age and sex showed no such changes. Our data support the hypothesis that NO is a pathogenic factor in MS, and that NOS IR is strongly expressed in brain regions appearing normal by MRI.
O que os empregadores pensam sobre o trabalho da pessoa com deficiência

Este estudo teve o objetivo de identificar o ponto de vista dos empregadores sobre a pessoa com deficiencia, o seu trabalho e a sua admissao como funcionaria da empresa. Os dados foram coletados por meio de entrevista semi-estruturada, junto a seis responsaveis pelo setor de recursos humanos de empresas pertencentes aos ramos de comercio, industria e prestacao de servicos. Os resultados indicaram que essas empresas possuiam funcionarios com diferentes tipos de deficiencia e a sua contratacao ocorreu, predominantemente, pela obrigatoriedade da lei. Os entrevistados acreditavam que as pessoas com deficiencia tinham condicoes de exercer um trabalho, mas apontaram algumas dificuldades em funcao: a) dela propria - falta de escolaridade, de interesse e de preparacao profissional e social; b) da empresa - condicoes inadequadas do ambiente fisico e social, falta de conhecimento sobre a deficiencia; c) das instituicoes especiais - inadequacao dos programas de treinamento profissional e social, falta de contato com as empresas para conhecer as suas necessidades; d) do governo - de proporcionar acesso a escola e ao transporte, falta de incentivo para as empresas promoverem adaptacoes ergonomicas e desenvolverem programas de responsabilidade social. Os cargos que os funcionarios com deficiencia ocupavam exigiam pouca qualificacao e o seu treinamento era realizado no proprio local de trabalho. A concepcao de que as dificuldades desse trabalhador eram decorrentes das suas condicoes orgânicas prevaleceu na fala desses entrevistados.
Infectious and inflammatory disorders of the circulatory system as risk factors for stroke in Saudi children.

OBJECTIVE To report on the role of infectious and inflammatory disorders as risk factors for stroke in a prospective and retrospective cohort of Saudi children. METHODS Children, who presented with stroke, were evaluated at the Division of Pediatric Neurology or admitted to King Khalid University Hospital, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia during the periods July 1992 to February 2001 (retrospective study) and February 2001 to March 2003 (prospective study). Investigations for suspected cases included hemostatic assays, microbiological and serological tests. Neuroimaging included cranial CT, MRI, magnetic resonance angiography (MRA), magnetic resonance venography (MRV) and single photon emission computed tomography (SPECT) brain scan. RESULTS Of the 104 Saudi children with stroke, seen during the combined study periods of 10 years and 7 months, infectious and inflammatory disorders of the circulatory system were the identified risk factor in 18 (17.3%). Five children had stroke following acute bacterial meningitis at ages ranging between 5-21 months. The causative organism was identified in 3 of them and consisted of Haemophilus influenzae (in a 5-month-old girl), Streptococcus pneumoniae (in a 21-month-old girl complicated by subdural empyema and sinovenous thrombosis), and Staphylococcus aureus in a 6-month-old boy who had an underlying chronic granulomatous disease. Unspecified meningitis/meningoencephalitis affected 4 patients, whereas 3 children had an underlying congenital infection as a cause for their stroke. Two of the latter 3 children were diagnosed to have congenital toxoplasmosis, and the third had congenital rubella syndrome. Two girls had stroke following septicemia at ages of one and 2 months. Neurobrucellosis caused stroke in 2 boys at the ages of 4 1/2 and 4 years. In both patients, neuroimaging revealed lacunar and other infarcts involving mainly the deep cerebral nuclei, secondary to occlusion of small penetrating end arteries. Two patients presented with cerebrovascular disease following systemic lupus erythematosus. These were a 12-year-old girl and a 5-year-old boy. CONCLUSIONS Several of the infectious diseases that caused stroke in this cohort of Saudi children are potentially preventable through childhood immunization programs or other maternity health programs. In particular, immunogenic conjugate vaccines against the 3 most common organisms causing acute bacterial meningitis (Haemophilus influenzae type b, Neisseria meningitidis and defined serotypes of Streptococcus pneumoniae) are needed to protect the young (<2 years) who are mostly affected.
Antibody prevalence and immunoglobulin IgG subclass pattern to norwalk virus in Sweden

The antibody prevalence in Sweden to Norwalk virus (NV) was investigated using a baculovirus expressed capsid antigen. One hundred thirty‐two serum samples were examined for IgA, total IgG and IgG subclass antibodies to Norwalk virus. In young children, NV IgG antibody prevalence was higher than the IgA prevalence, whereas no difference was found in individuals older than 21 years. The IgG antibody prevalence was 50% in children below 5 years of age and increased to >8O% in individuals older than 10 years of age. To examine the IgG antibody response in more detail, IgG subclass patterns were characterized. IgG 1 predominated in all age groups. IgG 4, usually detected after repeated exposure to antigen, was the second most prevalent subclass, but was only found in individuals olderthan 21 years of age. IgG 3 subclass antibodies were found in 13% and IgG 2 in 3% of the sera examined. IgG 3 subclass antibodies have been recognized as a marker for recent or ongoing viral infections. © 1995 Wiley‐Liss, Inc.
Potential for erythropoietin synthesis in kidney of uraemic rat alters depending on severity of renal failure

Aim: Renal anaemia is a common early complication of chronic renal failure (CRF) that is characterized by relative erythropoietin (EPO) deficiency. Although a lowered renal function is considered to induce limited EPO production, potential EPO production capacity in CRF remains unclear. The aim of this study was to determine the mechanisms underlying this relative deficiency.
A stochastic SIR model with contact-tracing: large population limits and statistical inference

This paper is devoted to the presentation and study of a specific stochastic epidemic model accounting for the effect of contact-tracing on the spread of an infectious disease. Precisely, one considers here the situation in which individuals identified as infected by the public health detection system may contribute to detecting other infectious individuals by providing information related to persons with whom they have had possibly infectious contacts. The control strategy, which consists of examining each individual who has been able to be identified on the basis of the information collected within a certain time period, is expected to efficiently reinforce the standard random-screening-based detection and considerably ease the epidemic. In the novel modelling of the spread of a communicable infectious disease considered here, the population of interest evolves through demographic, infection and detection processes, in a way that its temporal evolution is described by a stochastic Markov process, of which the component accounting for the contact-tracing feature is assumed to be valued in a space of point measures. For adequate scalings of the demographic, infection and detection rates, it is shown to converge to the weak deterministic solution of a PDE system, as a parameter n, interpreted as the population size, roughly speaking, becomes larger. From the perspective of the analysis of infectious disease data, this approximation result may serve as a key tool for exploring the asymptotic properties of standard inference methods such as maximum likelihood estimation. We state preliminary statistical results in this context. Eventually, relations of the model with the available data of the HIV epidemic in Cuba, in which country a contact-tracing detection system has been set up since 1986, is investigated and numerical applications are carried out.
Characterisation of particle dynamics and turnover in the gastrointestinal tract of Holstein cows fed forage diets differing in fibre and protein contents

An improved understanding of the role of forage quality on the processes of particle dynamics and turnover is important for the development of healthier and cost-effective feeding strategies that aim at lowering the proportions of concentrates in the diets of cattle. The aim of this study was to evaluate the effects of feeding hays of different qualities on particle dynamics, digestion kinetics and turnover in the gastrointestinal tract (GIT). Three non-lactating, rumen fistulated Holstein cows were fed diets consisting exclusively of hay with either low quality [Group LH; 605 ± 12.4 g/kg neutral detergent fibre (NDF) and 63 ± 4.7 g/kg crude protein (CP)] or good quality (Group GH; 551 ± 20.1 g/kg NDF and 116 ± 3.6 g/kg CP). Data showed that in situ dry matter (DM) disappearance of the soluble fraction was greater for Group GH (p < 0.05). Feeding good quality hay also lowered the proportion of particles >1.18 mm particularly during the eating process (p < 0.05). Changes in the particle size occurring afterwards were greater for Group GH as well (p < 0.05); approximately 30% in the comminution in the particle size occurred postruminally. Feeding hay of good quality lowered DM content of solid rumen digesta (p < 0.05), accelerated (p < 0.05) the turnover rate of DM and NDF in the GIT and increased DM intake (p < 0.05). In conclusion, feeding forages of better quality significantly promoted degradation processes and kinetics in the GIT with positive effects on turnover rate of digesta and feed intake in Holstein cows.
The gender gap in student engagement: The role of teachers' autonomy support, structure, and involvement.

BACKGROUND The gender gap in education in favour of girls is a widely known phenomenon. Boys generally have higher dropout rates, obtain lower grades, and show lower engagement. Insight into factors related to these academic outcomes could help to address the gender gap. AIMS This study investigated, for Dutch language classes, (1) how boys and girls differ in behavioural engagement, (2) which teacher support dimensions (autonomy support, structure, involvement) may explain gender differences in engagement (mediation hypothesis), and (3) whether and which of these teacher support dimensions matter more for boys' as opposed to girls' engagement (moderation or differential effects hypothesis). SAMPLE A total of 385 Grade 7 students and their 15 language teachers participated in this study. METHODS Teacher support was assessed through student reports. Student engagement was measured using student, teacher, and observer reports. By means of structural equation modelling, the mediating role of the teacher support dimensions for gender differences in behavioural engagement was tested. The potential differential role of the teacher support dimensions for boys' and girls' engagement was investigated through multigroup analysis. RESULTS Boys were less engaged than girls and reported lower support from their teacher. Autonomy support and involvement partially mediated the relationship between gender and behavioural engagement. Autonomy support was demonstrated to be a protective factor for boys' engagement but not for girls'. Structure and involvement contributed equally to engagement for both sexes. CONCLUSIONS Although involvement and autonomy support partly explained the gender gap in engagement (mediation hypothesis), more support was found for differential effects of autonomy support on boys' versus girls' engagement (differential effects hypothesis).
As in Humans, Pregnancy Increases the Clearance of the Protease Inhibitor Nelfinavir in the Nonhuman Primate Macaca nemestrina

The apparent oral clearance of protease inhibitors (PIs) is increased in pregnant women. Although this phenomenon is reproduced in the mouse, because of the multiplicity of mouse cytochrome P450 isoforms, lack of information on their substrate and inhibitor selectivity, and lack of reagents (e.g., antibodies, purified protein), it is difficult to study the mechanistic basis of this phenomenon in this animal model. To investigate the mechanistic basis of this phenomenon in a more representative model, the nonhuman primate, we first determined whether this phenomenon could be reproduced in Macaca nemestrina, using nelfinavir as a model PI. Consistent with the human and mouse studies, we found that the apparent oral clearance of nelfinavir (NFV) in the macaques was significantly increased (3.14-fold) antepartum (n = 3) versus postpartum (n = 4). This increased apparent oral clearance was a result of an increased systemic clearance (1.9-fold) and a decreased bioavailability (∼45%) during pregnancy. In vitro, pregnancy significantly enhanced the rate of NFV depletion in hepatic, but not intestinal S-9 fractions. Human CYP3A inhibitors erythromycin (0.5 mM), ketoconazole (0.5 μM), and troleandomycin (0.01–1 mM), but not the CYP2C inhibitor, sulfaphenazole (3 μM), significantly inhibited the depletion of NFV in hepatic S-9 fractions and expressed rhesus CYP3A64 enzyme. Based on these data, we conclude that increased hepatic activity of NFV-metabolizing enzymes (perhaps CYP3A enzymes) results in increased clearance of PIs during pregnancy in the macaques. The M. nemestrina should be further investigated as a model to study the mechanisms by which the clearance of PIs is increased during pregnancy.
Performance Assessment of Multi-Source Weighted-Ensemble Precipitation (MSWEP) Product over India

Error characterization is vital for the advancement of precipitation algorithms, the evaluation of numerical model outputs, and their integration in various hydro-meteorological applications. The Tropical Rainfall Measuring Mission (TRMM) Multi-satellite Precipitation Analysis (TMPA) has been a benchmark for successive Global Precipitation Measurement (GPM) based products. This has given way to the evolution of many multi-satellite precipitation products. This study evaluates the performance of the newly released multi-satellite Multi-Source Weighted-Ensemble Precipitation (MSWEP) product, whose temporal variability was determined based on several data products including TMPA 3B42 RT. The evaluation was conducted over India with respect to the IMD-gauge-based rainfall for pre-monsoon, monsoon, and post monsoon seasons at daily scale for a 35-year (1979–2013) period. The rainfall climatology is examined over India and over four geographical extents within India known to be subject to uniform rainfall. The performance evaluation of rainfall time series was carried out. In addition to this, the performance of the product over different rainfall classes was evaluated along with the contribution of each class to the total rainfall. Further, seasonal evaluation of the MSWEP products was based on the categorical and volumetric indices from the contingency table. Upon evaluation it was observed that the MSWEP products show large errors in detecting the higher quantiles of rainfall (>75th and > 95th quantiles). The MSWEP precipitation product available at a 0.25° × 0.25° spatial resolution and daily temporal resolution matched well with the daily IMD rainfall over India. Overall results suggest that a suitable region and season-dependent bias correction is essential before its integration in hydrological applications. While the MSWEP was observed to perform well for daily rainfall, it suffered from poor detection capabilities for higher quantiles, making it unsuitable for the study of extremes.
A cloned avirulence gene from Pseudomonas solanacearum determines incompatibility on Nicotiana tabacum at the host species level

A locus in Pseudomonas solanacearum AW1 responsible for the hypersensitive response (HR) on tobacco was cloned by complementation in the tobacco-pathogenic strain P. solanacearum NC252. The NC252 HR+ transconjugants lost pathogenicity on tobacco, indicating that the cloned locus could restrict the host range of NC252. Restriction enzyme mapping, transposon mutagenesis, and subcloning showed that, at most, 2.0 kilobases of the cloned DNA was required for NC252 transconjugants to elicit HR on tobacco. Site-directed insertional mutagenesis of the wild-type locus in strain AW1 to create AW1-31 eliminated HR activity on tobacco. However, AW1-31 retained pathogenicity on tomato and eggplant, confirming that this locus contains an avirulence gene, designated avrA. In contrast to the wild type, AW1-31 multiplied to almost the same extent as NC252 after infiltration into tobacco leaves. Nevertheless, AW1-31 did not wilt tobacco when stem inoculated, suggesting that additional factors condition host range. AW1 was HR+ on 27 N. tabacum cultivars, whereas AW1-31 was always HR-, strongly suggesting that avrA is specific at the host species level.
Dirofilaria aethiops Webber, 1955, a filarial parasite of monkeys I. The morphology of the adult worms and microfilariae

1. Dirofilaria aethiops Webber, 1955 has been discovered in African monkeys (Cercopithecus aethiops). Adult worms were found in the interfascicular connective tissue, especially in the thighs; microfilariae were found in the blood. 2. The adult worms are morphologically similar to other members of the genus, from which they differ principally in the structure of the spicules of the male worms. The thickening of the left spicule is complex at the twist; the latter is nearer to the proximal than to the distal end. The right spicule is robust and ends in a cap-like structure. 3. The microfilariae are indistinguishable from those of other members of the genus. 4. In Dirofilaria schoutedeni Vuylsteke & Rodhain, 1938 the left spicule is simpler in structure than the left spicule of D. aethiops, and the twist is nearer to the distal end than to the proximal end. The distal part of the right spicule of D. schoutedeni has longitudinal markings but no cap. 5. D. aethiops has been recorded from Tanganyika, Uganda and Gambia, in Cercopithecus and Colobus monkeys. 6. The anatomy of the female D. aethiops, as it is shown in serial sections, is briefly described.
Constitutive and Aging Behavior of Sn3.0Ag0.5Cu Solder Alloy

We describe double-lap shear experiments on Sn3.0Ag0. 5Cu solder alloy, from which fits to Anand's viscoplastic constitutive model, power-law creep model, and to time-hardening primary-secondary creep model are derived. Results of monotonic tests for strain rates ranging from 4.02E-6 to 2.40E-3 s-1, and creep response at stress levels ranging from 19.5 to 45.6 MPa are reported. Both types of tests were conducted at temperatures of 25degC, 75degC , and 125degC. Following an earlier study where Anand model and time hardening creep parameters for Sn3.8Ag0. 7Cu and Sn1.0Ag0. 5Cu solder alloys were reported, here we report power law model parameters so as to enable a comparison between all three alloys. Primary creep in Sn3.0Ag0. 5Cu solder alloy is shown to be significant and are considered in addition to secondary creep and monotonic behavior. Aging influence on behavior is also shown to be significant. On the basis of experimental data, the following four aspects are discussed: 1) difference between testing on bulk versus joint specimen; 2) consistency between the creep and monotonic behaviors; 3) comparison against behaviors of Sn1.0Ag0. 5Cu and Sn3.8Ag0. 7Cu alloys as well as aganist Sn40Pb, 62Sn36Pb2Ag and 96.5Sn3. 5Ag alloys; and 4) comparison of Sn3.0Ag0. 5Cu and Sn3.8Ag0. 7Cu relative to their aging response.
Adaptive Cardinality Estimation

In this paper we address cardinality estimation problem which is an important subproblem in query optimization. Query optimization is a part of every relational DBMS responsible for finding the best way of the execution for the given query. These ways are called plans. The execution time of different plans may differ by several orders, so query optimizer has a great influence on the whole DBMS performance. We consider cost-based query optimization approach as the most popular one. It was observed that cost-based optimization quality depends much on cardinality estimation quality. Cardinality of the plan node is the number of tuples returned by it. In the paper we propose a novel cardinality estimation approach with the use of machine learning methods. The main point of the approach is using query execution statistics of the previously executed queries to improve cardinality estimations. We called this approach adaptive cardinality estimation to reflect this point. The approach is general, flexible, and easy to implement. The experimental evaluation shows that this approach significantly increases the quality of cardinality estimation, and therefore increases the DBMS performance for some queries by several times or even by several dozens of times.