Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinical Outcomes After Intensifying Antihypertensive Medication Regimens Among Older Adults at Hospital Discharge.

Importance Transient elevations of blood pressure (BP) are common in hospitalized older adults and frequently lead practitioners to prescribe more intensive antihypertensive regimens at hospital discharge than the patients were using before hospitalization. Objective To investigate the association between intensification of antihypertensive regimens at hospital discharge and clinical outcomes after discharge. Design, Setting, and Participants In this retrospective cohort study, patients 65 years and older with hypertension who were hospitalized in Veterans Health Administration national health system facilities from January 1, 2011, to December 31, 2013, for common noncardiac conditions were studied. Data analysis was performed from October 1, 2018, to March 10, 2019. Exposures Discharge with antihypertensive intensification, defined as receiving a prescription at hospital discharge for a new or higher-dose antihypertensive than was being used before hospitalization. Propensity scores were used to construct a matched-pairs cohort of patients who did and did not receive antihypertensive intensifications at hospital discharge. Main Outcomes and Measures The primary outcomes of hospital readmission, serious adverse events, and cardiovascular events were assessed by competing risk analysis. The secondary outcome was the change in systolic BP within 1 year of hospital discharge. Results The propensity-matched cohort included 4056 hospitalized older adults with hypertension (mean [SD] age, 77 [8] years; 3961 men [97.7%]), equally split between those who did vs did not receive antihypertensive intensifications at hospital discharge. Groups were well matched on all baseline covariates (all standardized mean differences <0.1). Within 30 days, patients receiving intensifications had a higher risk of readmission (hazard ratio [HR], 1.23; 95% CI, 1.07-1.42; number needed to harm [NNH], 27; 95% CI, 16-76) and serious adverse events (HR, 1.41; 95% CI, 1.06-1.88; NNH, 63; 95% CI, 34-370). At 1 year, no differences were found in cardiovascular events (HR, 1.18; 95% CI, 0.99-1.40) or change in systolic BP among those who did vs did not receive intensifications (mean BP, 134.7 vs 134.4; difference-in-differences estimate, 0.6 mm Hg; 95% CI, -2.4 to 3.7 mm Hg). Conclusions and Relevance Among older adults hospitalized for noncardiac conditions, prescription of intensified antihypertensives at discharge was not associated with reduced cardiac events or improved BP control within 1 year but was associated with an increased risk of readmission and serious adverse events within 30 days.
Clinicopathological features of Epstein-Barr virus-associated gastric carcinoma: A systematic review and meta-analysis.

PURPOSE The purpose of this meta-analysis was to explore the clinicopathological characteristics of Epstein-Barr virus (EBV)-associated gastric carcinoma (AGC) based on qualified studies. METHODS PubMed, Cochrane and Embase databases updated to November 2017 were searched by the index words to identify relevant studies, including qualified randomized controlled trials, cohort studies or case-control studies. Studies were also identified by tracking reference lists. The meta-analysis included relative risks (RR), mean difference (MD) along with 95% confidence interval (95% CI) to analyze the main outcomes. RESULTS A total of 35 studies were included in this meta-analysis with 7540 cases and 950 Epstein-Barr virus associated gastric cancer (EBVaGC) cases. The results indicated the EBV infection rate was significantly higher in males than in females (OR, 0.42; 95%CI 0.35-0.52), and the EBV infection rate was significantly higher in the diffuse type than in intestinal type (OR, 1.56; 95%CI 1.24-1.97). Besides, there was no marked association of EBV infection rate with lymph node metastasis (OR, 0.73; 95%CI 0.41-1.29), age (OR, 0.78; 95%CI 0.61-1.00) and pathologic tumor stage (OR, 1.11; 95%CI 0.90-1.38). The results of funnel plot, Begg's and Mazumdar's rank test, and Egger's test all showed no significant publication bias. CONCLUSIONS In this meta-analysis, EBV infection rate was significantly higher in males and in diffuse cancer type. However, there was no marked association with lymph node metastasis, age and pathologic tumor stage. Thus, EBV-positive gastric cancer has distinct clinicopathological features.
Effects of dietary inulin supplementation on the composition and dynamics of cecal microbiota and growth-related parameters in broiler chickens

Inulin, a prebiotic, is an attractive alternative to antibiotic growth promoters in chickens. Dietary supplementation with inulin can improve growth performance, carcass yield, immune system activity, and serum biochemical parameters in chickens. A few studies investigated the impact of dietary inulin supplementation on chicken intestinal microbiota. In this study, we investigated how and why dietary supplementation with 1, 2, and 4% inulin can affect body weight gain, feed intake, food conversion rate, immunological parameters, serum biochemical parameters, and composition and dynamics of the cecal microbiota of Tegel broiler chickens using quantitative fluorescence in situ hybridization (qFISH). We showed that inulin inclusion has a negative effect on growth performance parameters before day 21 and a positive effect subsequently up to day 42. Quantitative FISH data revealed an age-dependent change in the cecal microbiota in the control broilers fed no inulin. Thus, relative abundances of Firmicutes and Actinobacteria decreased from 52.8 to 48.3% of total cells and from 8.7 to 1.4% at days 7 and 42, respectively. However, relative abundances of Bacteroidetes and Proteobacteria gradually increased from 9.3 to 26.9% of the total cells and from 10.7 to 21.1%, respectively, over the same periods. Inulin inclusion appeared to lower the relative abundances of Lactobacillus johnsonii and Bifidobacterium species at an early bird age, but it subsequently significantly (P < 0.05) increased their relative abundances. Such increases positively correlated with body weight gain of the birds, determined after day 21. Thus, dietary supplementation with inulin together with the addition of L. johnsonii and Bifidobacterium (B. gallinarum and B. pullorum) cultures at an early age may help overcome its early negative influence on growth performance. We believe that these findings can improve our knowledge on how inulin can change the intestinal microbiota of broiler chickens and help in developing an inulin feeding regime to optimize its beneficial role in chicken development.
Childhood trauma and being at-risk for psychosis are associated with higher peripheral endocannabinoids

Abstract Background Evidence has been accumulating regarding alterations in components of the endocannabinoid system in patients with psychosis. Of all the putative risk factors associated with psychosis, being at clinical high-risk for psychosis (CHR) has the strongest association with the onset of psychosis, and exposure to childhood trauma has been linked to an increased risk of development of psychotic disorder. We aimed to investigate whether being at-risk for psychosis and exposure to childhood trauma were associated with altered endocannabinoid levels. Method We compared 33 CHR participants with 58 healthy controls (HC) and collected information about previous exposure to childhood trauma as well as plasma samples to analyse endocannabinoid levels. Results Individuals with both CHR and experience of childhood trauma had higher N-palmitoylethanolamine (p < 0.001) and anandamide (p < 0.001) levels in peripheral blood compared to HC and those with no childhood trauma. There was also a significant correlation between N-palmitoylethanolamine levels and symptoms as well as childhood trauma. Conclusions Our results suggest an association between CHR and/or childhood maltreatment and elevated endocannabinoid levels in peripheral blood, with a greater alteration in those with both CHR status and history of childhood maltreatment compared to those with either of those risks alone. Furthermore, endocannabinoid levels increased linearly with the number of risk factors and elevated endocannabinoid levels correlated with the severity of CHR symptoms and extent of childhood maltreatment. Further studies in larger cohorts, employing longitudinal designs are needed to confirm these findings and delineate the precise role of endocannabinoid alterations in the pathophysiology of psychosis.
Oleic acid in the absence of a PPARγ agonist increases adipogenic gene expression in bovine muscle satellite cells.

We hypothesized that oleic acid in the absence of a thiazolidinedione (i.e., a synthetic peroxisome proliferator activated receptorγ (PPARγ) agonist) would increase adipogenic gene expression in bovine muscle satellite cells (BSC). The BSC were cultured in differentiation medium containing 10 µM ciglitazone (CI), 100 µM oleic acid (OA), or 100 µM oleic acid plus 10 µM ciglitazone (CI-OA). Control (CON) BSC were cultured only in differentiation media (containing 2% horse serum). The presence of myogenin, desmin, and paired box 7 proteins was confirmed in the BSC by immunofluorescence staining, demonstrating that we had isolated myogenic cells. The OA BSC had lesser paired box 3 (pax3) and myogenic differentiation 1 expression, but greater pax7 and mygogenin (MYOG) expression (P < 0.05), than the CON BSC. The CI BSC had greater pax3, pax7, and MYOG expression than CON BSC (P < 0.05), suggesting that ciglitazone would promote BSC myogenesis under pro-myogenic conditions (i.e., when cultured with horse serum). However, both the OA and CI treatments upregulated the expression of PPARγ, CCAAT/enhancer-binding protein alpha (C/EBPα) and C/EBPß, sterol regulatory element-binding protein 1, lipoprotein lipase, and glycerol-3-phosphate acyltransferase 3 gene expression, as well as media adiponectin concentration (P < 0.05). The CI, OA, and CI-OA treatments also increased triacylglycerol and lipid droplet accumulation, in spite of up-regulation (relative to CON BSC) of AMP-activated protein kinase alpha-1, perilipin 2 (PLIN2), and PLIN3 in BSC and downregulation of G protein-coupled protein receptor 43, acyl-CoA synthetase long chain family member 3, and stearoyl-CoA desaturase (P < 0.05). These results indicate that oleic acid in the absence of a synthetic PPARγ agonist can effectively increase adipogenic gene expression in BSC.
Volumetric Bioprinting of Complex Living‐Tissue Constructs within Seconds

Biofabrication technologies, including stereolithography and extrusion‐based printing, are revolutionizing the creation of complex engineered tissues. The current paradigm in bioprinting relies on the additive layer‐by‐layer deposition and assembly of repetitive building blocks, typically cell‐laden hydrogel fibers or voxels, single cells, or cellular aggregates. The scalability of these additive manufacturing technologies is limited by their printing velocity, as lengthy biofabrication processes impair cell functionality. Overcoming such limitations, the volumetric bioprinting of clinically relevant sized, anatomically shaped constructs, in a time frame ranging from seconds to tens of seconds is described. An optical‐tomography‐inspired printing approach, based on visible light projection, is developed to generate cell‐laden tissue constructs with high viability (>85%) from gelatin‐based photoresponsive hydrogels. Free‐form architectures, difficult to reproduce with conventional printing, are obtained, including anatomically correct trabecular bone models with embedded angiogenic sprouts and meniscal grafts. The latter undergoes maturation in vitro as the bioprinted chondroprogenitor cells synthesize neo‐fibrocartilage matrix. Moreover, free‐floating structures are generated, as demonstrated by printing functional hydrogel‐based ball‐and‐cage fluidic valves. Volumetric bioprinting permits the creation of geometrically complex, centimeter‐scale constructs at an unprecedented printing velocity, opening new avenues for upscaling the production of hydrogel‐based constructs and for their application in tissue engineering, regenerative medicine, and soft robotics.
Proximal Bone Remodeling in Lower Limb Amputees Reconstructed With an Osseointegrated Prosthesis

Mobility outcomes and changes in bone mineral density (BMD) of the spine and femoral necks in response to unilateral osseointegrated implants was investigated over a 3‐year period. A total of 48 unilateral amputees who received an osseointegrated implant, comprising 33 trans‐femoral amputees (TFA) and 15 trans‐tibial amputees (TTA), underwent dual‐energy X‐ray absorptiometry (DXA) scans of the lumbar spine (L2–L4) and femoral necks at baseline, 1‐, and 3‐years follow‐ups. Mobility outcomes, including the Six‐Minute‐Walk Test (6MWT) and Timed‐Up‐and‐Go (TUG), were measured before surgery, at 1 year, and more than 2 years following the osseointegration procedure. We observed a significant increase (p < 0.05) in Z‐score values in the femoral neck of the amputated side in TFA patients without a femoral neck lag screw at the 1‐ and 3‐year follow‐ups, as well as in TFA patients with a lag screw present at 3‐year follow‐up. The BMD at 1‐year follow‐up was found to be positively correlated with pre‐surgery 6MWT values in patients who were mobile using a traditional socket prosthesis before receiving an osseointegrated implant. These results suggest that osseointegrated implants induce a physiological response in the femoral neck of recipients and appear to be evidence of restored biomechanical loading in the proximal femur. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:2524–2530, 2019
Insulin-like growth factor axis in pregnancy and gestational diabetes mellitus.

The insulin-like growth factor (IGF) is involved in the regulation of growth and metabolism. The aim of this study was to determine selected parameters of IGF system at systemic and local levels [subcutaneous (SAT) and visceral adipose tissue (VAT)] to assess its possible role in gestational diabetes mellitus (GDM). 37 pregnant women (21 with GDM and 16 without GDM) and 15 age-matched non-pregnant females were included in the study. Blood samples were taken in 28-32 and 36-38 weeks of gestation and 6-12 months after delivery. SAT and VAT samples were obtained during delivery or surgery. Compared with non-pregnant women, serum IGF-1 and IGFBP-3 were increased in both groups of pregnant women. IGF-2 was elevated only in GDM women from 36 weeks of gestation culminating 6 months after delivery (p=0.003). Serum IGFBP-3 was increased and IGFBP-4 decreased in GDM women vs. pregnant women without GDM during the whole study (IGFBP-3: p<0.001 for GDM vs. non-GDM; IGFBP-4: p=0.004 for GDM vs. non-GDM). Pregnant women with GDM had decreased mRNA expression of IGF-1, IGF-1R and IGF-2R and IGFBP-4 in VAT and IGF-1R in SAT compared to pregnant women without GDM. Changes in local activity of IGF are associated with the development of GDM.
Anthracycline Chemotherapy-Induced Cardiotoxicity in Breast Cancer Survivors: A Systematic Review.

PROBLEM IDENTIFICATION This review identifies specific cardiotoxicity related to anthracycline chemotherapy, specific risk factors related to increased anthracycline chemotherapy-induced cardiotoxicity, and underlying mechanisms of action of anthracycline chemotherapy-induced cardiotoxicity. LITERATURE SEARCH PubMed®, CINAHL®, Embase®, and Web of Science were searched in May 2018 using keywords related to heart diseases, anthracycline chemotherapy, and breast cancer. DATA EVALUATION Data were extracted, and study quality was assessed according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. SYNTHESIS 1,117 articles were identified through the literature search. After a review of the abstracts and articles, 15 clinical studies were identified for the final analysis by using exclusion and inclusion criteria. IMPLICATIONS FOR PRACTICE Nurses should recognize the critical elements for prevention and early detection of anthracycline chemotherapy-induced cardiotoxicity.
Orally administered resveratrol enhances the therapeutic effect of autologous transplanted adipose-derived stem cells on rats with diabetic hepatopathy

ABSTRACT Stem cell therapy is a promising treatment for hepatopathy due to diabetes mellitus (DM); oral resveratrol treatment exhibits protective effects. We investigated whether protective effects could be produced in liver of diabetic rats receiving autologous adipose-derived stem cell transplantation (ADSC) plus oral resveratrol administration. Male rats were divided into four groups: sham group; streptozotocin induced DM group; DM + ADSC group, in which DM rats were treated with 106 stem cells/rat; and DM + R + ADSC group, in which DM rats were treated with ADSC and oral resveratrol. The DM group exhibited apoptosis, inflammation and fibrosis, whereas Sirt-1 and survival signaling were suppressed. Pathological conditions other than survival signaling were improved in the DM + ADSC group. All pathological conditions were improved in the DM + R + ADSC group. Also, the oxidative stress level in the blood was reduced in the DM + R + ADSC group compared to the sham group. Oral resveratrol administration appears to reduce oxidative damage and enhances survival signaling in diabetic liver. The therapeutic response in the DM + R + ADSC group was better than in the DM + ADSC group.
Stevia rebaudiana Bertoni bioactive effects: From in vivo to clinical trials towards future therapeutic approaches

Stevia rebaudiana Bertoni, a plant from South America and indigenous of Paraguay, has shown several biological effects and healthy properties, although it is especially used in South America and some Asiatic regions. In addition, it is a natural sweetener, almost 300 times sweeter than sucrose, being attributed to its phytoconstituents prominent antioxidant, antimicrobial, antidiabetic (antihyperglycemic, insulinotropic, and glucagonostatic), antiplatelet, anticariogenic, and antitumor effects. In this sense, this work aims to provide an extensive overview on the historical practices of stevia and its effects in human health based on its chemical composition and applications for both food and pharmaceutical industries.
Treatment efficacy for adult persistent immune thrombocytopenia: a systematic review and network meta‐analysis

Persistent immune thrombocytopenia (ITP) patients require second‐line treatments, for which information on clinical outcomes are lacking. A systematic review and network meta‐analysis (NMA) were conducted. Only randomised controlled trials (RCT) of second‐line drugs in adult persistent ITP patients with platelet response, platelet count, any bleeding or serious adverse events (SAE) outcome were eligible. Twelve RCTs (n = 1313) were included in NMA. For platelet response outcome, eltrombopag and romiplostin were the best relative to placebo; the former had a non‐significant advantage [risk ratio (RR) = 1·10 (95% confidence interval: 0·46, 2·67)]. Both treatments were superior to rituximab and recombinant human thrombopoietin (rhTPO)+rituximab, with corresponding RRs of 4·56 (1·89, 10·96) and 4·18 (1·21, 14·49) for eltrombopag; 4·13 (1·56, 10·94) and 3·79 (1·02, 14·09) for romiplostim. For platelet count, romiplostim ranked highest, followed by eltrombopag, rhTPO+rituximab, and rituximab. For bleeding, rituximab had lowest risk, followed by eltrombopag and romiplostim. For SAEs, rhTPO+rituximab had highest risk, followed by rituximab, eltrombopag and romiplostim. From clustered ranking, romiplostim had the best balance between short‐term efficacy and SAEs, followed by eltrombopag. In conclusion, romiplostim and eltrombopag may yield high efficacy and safety. Rituximab may not be beneficial due to lower efficacy and higher complications compared with the thrombopoietin receptor agonists. RCTs with long‐term clinical outcomes are required.
Social context and the real-world consequences of social anxiety

Abstract Background Social anxiety lies on a continuum, and young adults with elevated symptoms are at risk for developing a range of psychiatric disorders. Yet relatively little is known about the factors that govern the hour-by-hour experience and expression of social anxiety in the real world. Methods Here we used smartphone-based ecological momentary assessment (EMA) to intensively sample emotional experience across different social contexts in the daily lives of 228 young adults selectively recruited to represent a broad spectrum of social anxiety symptoms. Results Leveraging data from over 11 000 real-world assessments, our results highlight the central role of close friends, family members, and romantic partners. The presence of such close companions was associated with enhanced mood, yet socially anxious individuals had fewer confidants and spent less time with the close companions that they do have. Although higher levels of social anxiety were associated with a general worsening of mood, socially anxious individuals appear to derive larger benefits – lower levels of negative affect, anxiety, and depression – from their close companions. In contrast, variation in social anxiety was unrelated to the amount of time spent with strangers, co-workers, and acquaintances; and we uncovered no evidence of emotional hypersensitivity to these less-familiar individuals. Conclusions These findings provide a framework for understanding the deleterious consequences of social anxiety in emerging adulthood and set the stage for developing improved intervention strategies.
Brokering orientations and social capital: Influencing others' relationships shapes status and trust.

Individuals often influence others' relationships, for better or worse. We conceptualize social influence processes that impact others' social networks as brokering, and advance a multifaceted model that explains how brokering behaviors can create, terminate, reinforce, and modify others' network ties. To empirically study brokering, we introduce and validate the Brokering Orientations Scale (BOS), a multidimensional measure that captures individuals' behavioral tendencies to act as intermediaries, conciliators, and dividers. Six studies (N = 1,723) explored the psychometric properties of the BOS (Studies 1a-c) and investigated the effects of distinct forms of brokering on brokers' social capital (Studies 2-4). The intermediary, conciliatory and divisive brokering orientations related differently to extraversion, agreeableness, perspective-taking, moral identity, and Machiavellianism, among other individual differences. The effects of brokering on social capital varied as a function of the brokering orientation and the aspect of social capital. Intermediary behavior garnered status; conciliatory behavior promoted trust and prestige; and divisive behavior fueled brokers' perceived dominance. Overall, the current article elucidates the concept of brokering orientations, introduces a novel measure of brokering orientations, and explains how brokering behavior shapes brokers' social capital. (PsycINFO Database Record (c) 2019 APA, all rights reserved).