Miracle-dz/UniFAR-FTUs huggingface dataset:
Remission of Endometriosis by Hyperbaric Oxygen Treatment in Rats

We designed this prospective, randomized controlled animal study to determine the effects of hyperbaric oxygen (HBO) on experimentally induced endometriosis in a rat model. Surgical induction of endometriosis was performed in 40, nonpregnant, female, Wistar-Albino rats at the Experimental Medicine Research Center of Istanbul University (DETAE). Four weeks later, the first and second laparotomies for volume measurement and peritoneal fluid (PF) collection were performed, and the rats were divided randomly into the study and control groups. The study group was exposed to HBO treatment for 6 weeks. Then, a third laparotomy was performed on all of the rats. The volume, histopathologic scores, Ki-67 labeling of the endometriotic implants, and the levels of tumor necrosis factor-α (TNF-α) in the PF were measured. The mean volume of the endometriotic implants in the study group was significantly lower than that of the control group at the end of the study (57.4 ± 12.5 vs 94.6 ± 17.2 mm3). The mean histopathological scores (1.60 ± 0.50 vs 2.42 ± 0.51), Ki-67 immunohistochemical scores (1.50 ± 0.51 vs 2.37 ± 0.49) of the endometriotic implants, and the TNF-α levels (5.33 ± 1.02 vs 8.16 ± 1.76 pg/mL) were significantly lower in the study group than in the control group. Hyperbaric oxygen treatment for 2 hours a day for 6 weeks resulted in significant remission of endometriosis in rats.
On Carcinoma Growth and Vascular Supply: A Study of Mouse Mammary Tumor Strain MTG-B 1

Summary The vascular supply of the grossly viable portions of grafts of the MTG-B mouse mammary carcinoma was measured with 59Fe-labeled red cells. The relative vascular space was constant, estimated as 1.5 X 10-2 μl/mg in tumors yielding 50 to 1900 mg of “cleaned” tissue from which necrotic, cystic, or hemorrhagic areas had been removed. We have previously reported that the potential growth rate in the grossly viable portions of MTG-B tumors is also constant from the time tumors are small until near death of the host animals. It is postulated that an equilibrium between the viable portions of such tumors and their vascular supply is established when tumors are small. This equilibrium persists well into the period when tumors are large; and necrosis, hemorrhage, and cysts are common. It is thus further suggested that such degenerative changes become marked when the absolute number of new tumor cells born exceeds the capacity for new vascular tissue formation. However, the functional vascular supply of the regions from which most, if not all, new cells arise in large tumors of this type is apparently adequate to support the same metabolic and proliferative rates as in small tumors, despite the occurrence of widespread degeneration in adjacent areas. Insofar as the response to therapy depends on the relative vascular supply and proliferative rate, the sensitivity per unit viable tissue would be expected to be similar in large and small tumors of this type.
ON an improved delay-dependent robust stability criterion and application to power system statbility analysis with time delays

In this paper, Lyapunov stability theory and linear matrix inequality (LMI) method are used to analyze the delay-dependent robust stability of power systems with multiple time delays. An improved delay-dependent robust stability criterion for power system with multiple time delays is presented. A proper Lyapunov functional is firstly constructed based on Lyapunov-Krasovskii theory. And, in the deduction of its derivative function along the system trajectory, some necessary slack variables are introduced so as to reduce its conservatism. Then the method is applied to the robust stability analysis for power system with time-varying delays and uncertainties. It can be found the present method is correct, effective and with less conservatism.
ADAMTS4 and its proteolytic fragments differentially affect melanoma growth and angiogenesis in mice

The metalloproteinase ADAMTS4 (ADAMTS, a disintegrin‐like and metalloproteinase with thrombospondin motif)/aggrecanase‐1 is highly expressed in cartilage and has been implicated in human arthritis. Although abundantly expressed in many types of cancer, its role in cancer remains unknown. In this work, we demonstrate for the first time that full‐length ADAMTS4 and its catalytically more active N‐terminal 53 kDa autocatalytic fragment both promote B16 melanoma growth and angiogenesis in mice. In contrast, overexpression of its catalytically inactive E362A mutant or truncated fragments containing only the C‐terminal ancillary domains suppresses melanoma growth and angiogenesis under similar conditions. Structure–function mapping revealed that the single thrombospondin‐type 1 repeat domain is essential and sufficient for the antitumorigenic activity displayed by the catalytically inactive ADAMTS4 isoforms. Suppression of tumor growth and angiogenesis in mice is accompanied by a significant increase in tumor cell apoptosis, whereas tumor cell proliferation is not affected. Importantly, we identified and demonstrated the presence of novel proteolytic fragments of ADAMTS4 containing essentially only the C‐terminal ancillary domains in cultured cells, and also in human cancer tissues, coexisting with full‐length and catalytically active N‐terminal fragments. The contrasting functions toward tumor growth in mice by the wild‐type proteinase and its catalytically inactive mutant correlate with their contrasting influences on angiogenesis signaling pathway molecules in B16 melanoma in mice. Our results suggest a complex role for ADAMTS4 in cancer with the functional balance of protumorigenic and antitumorigenic isoforms likely to act as an important parameter in determining the net influence of this metalloproteinase on tumor growth in vivo.
Prevalence of Depression among Undergraduate Students: Gender and Age Differences

Depressive disorders are the most typical disease affecting many different factors of humanity. University students may be at increased risk of depression owing to the pressure and stress they encounter. Therefore, the purpose of this study is comparing the level of depression among male and female athletes and non-athletes undergraduate student of private university in Esfahan, Iran. The participants in this research are composed of 400 male and female athletes as well as no-athletes Iranian undergraduate students. The Beck depression test (BDI) was employed to measure the degree of depression. T-test was used to evaluate the distinction between athletes and non-athletes at P≤0.05. The ANOVA was conducted to examine whether there was a relationship between level of depression among non-athletes and athletes. The result showed that the prevalence rate of depression among non-athlete male undergraduate students is significantly higher than that of athlete male students. The results also presented that level of depression among female students is much more frequent compared to males. This can be due to the fatigue and lack of energy that are more frequent among female in comparison to the male students. Physical activity was negatively related to the level of depression by severity among male and female undergraduate students. However, there is no distinct relationship between physical activity and level of depression according to the age of athlete and non-athlete male and female undergraduate students. This study has essential implications for clinical psychology due to the relationship between physical activity and prevalence of depression.
The Cosmic Evolution Survey (COSMOS): Subaru Observations of the HST Cosmos Field

We present deep optical imaging observations of 2 square degree area, covered by the Cosmic Evolution Survey (COSMOS), made by the prime-focus camera (Supreme-Cam) on the 8.2 m Subaru Telescope. Observations were done in six broadband [B (4459.7 Å), g′ (4723.1 Å), V (5483.8 Å), r′ (6213.0 Å), i′ (7640.8 Å), z′ (8855.0 Å)] and one narrowband (NB816) filters. A total of 106 galaxies were detected to i′ ~ 26.5 mag. These data, combined with observations at u* and K-band are used to construct the photometric catalogs for the COSMOS, to measure their photometric redshifts, multiband spectral energy distributions, and stellar masses, and to identify high-redshift candidates. This catalog provides multi-wave band data for scientific analysis of the COSMOS survey.
Sequence analysis of the major outer membrane protein gene of Chlamydia pneumoniae

Compared with the major outer membrane proteins (MOMPs) of the other chlamydial species, the Chlamydia pneumoniae MOMP appears to be less antigenically complex, and as determined by immunoblot analysis, it does not appear to be the immunodominant antigen recognized during infection. Nucleotide sequence analysis of the C. pneumoniae MOMP gene (ompA) revealed that it consisted of a 1,167-base open reading frame with an inferred 39,344-dalton mature protein of 366 amino acids plus a 23-amino-acid leader sequence. A ribosomal-binding site was located in the 5' upstream region, and two stop codons followed by an 11-base dyad forming a stable stem-loop structure were identified. This sequence shares 68 and 71% DNA sequence homology to the Chlamydia trachomatis serovar L2 and Chlamydia psittaci ovine abortion agent MOMP genes, respectively. Interspecies alignment identified regions, corresponding to the variable domains, which share little sequence similarity with the other chlamydial MOMPs. All seven cysteines conserved in the C. trachomatis and C. psittaci MOMPs, which are involved in the formation of disulfide cross-linkages, are found in the C. pneumoniae MOMP.
Seasonality and histopathology of Trichodina puytoraci Lom , 1962 , a parasite of flathead mullet ( Mugil cephalus ) from Tunisia

Trichodinid Ciliophorans are one of the most common and widely dispersed groups of symbionts as parasites of aquatic invertebrate and vertebrate hosts (VAN AS & BASSON, 1989). The taxonomy of Trichodinids is based on the structure and the appearance of the adhesive disc and number and size of its constituents. All of these features can be revealed only by the silver impregnation technique of Klein (KLEIN, 1958). Consequently, the numerous species identified early without silver techniques are inadequately described (LOM & DYKOVA, 1992). Today, ten genera are described within the family Trichodinidae. The genus Trichodina Ehrenberg, 1838 is the largest of this family; more than 200 species have been described from fish (ASMAT et al., 2005). Trichodinids have During a parasitological survey in Ghar El Melh Lagoon in Tunisia, 108 flathead mullet (Mugil cephalus L., 1758) were investigated for protozoan ectoparasites. Trichodina puytoraci Lom, 1962 infecting the gills of the examined fish were isolated and reported for the first time from this locality. The overall infestation prevalence and mean intensity level were 22.42 % and 70 ± 8.1 trichodinids per fish, respectively. The highest prevalence was observed in spring. The relationship between host’s size and parasite prevalence was significant. The histopathological study revealed that M. cephalus heavily infested by T. puytoraci exhibited serious lesions such as hyperplasia of the epithelial cells, fusion and necrosis of secondary lamellae.
A Novel Full Adder with High Speed Low Area

In most of the digital systems adder lies in the critical path that effects the overall speed of the system. So enhancing the performance of the 1-bit full adder cell is the main design aspect. The paper proposes the novel design of a 3T XOR gate combining complementary CMOS with pass transistor logic. The design has been compared with earlier proposed 4T and 6T XOR gates and a significant improvement in silicon area and power-delay product has been obtained. An eight transistor full adder has been designed using the proposed three transistor XOR gate. Compared to the earlier designed 10, 14, 16 transistor full adder, the proposed adder shows a significant improvement in silicon area and power delay product.
Myosin heavy chain isoform transitions in canine skeletal muscles during postnatal growth

To gain a better understanding of the normal characteristics of developing canine muscles, myosin heavy chain (MHC) isoform expression was analysed in the axial and limb skeletal muscles of 18 young dogs whose ages ranged from the late prenatal stage to 6 months. We compared the results of immunohistochemistry using ten monoclonal antibodies, specific to different MHC isoforms, and enzyme‐histochemical reactions, which demonstrate the activity of myofibrillar ATPase, succinate dehydrogenase (SDH) and α‐glycerophosphate dehydrogenase (α‐GPDH). In the skeletal muscles of fetuses and neonatal dogs the developmental isoforms MHC‐emb and MHC‐neo were prevalent. In all muscles the primary fibres, located centrally in each muscle fascicle, strongly expressed the slow isoform MHC‐I. The adult fast isoform MHC‐IIa was first noted in some of the secondary fibres on fetal day 55. During the first 10 days after birth, the expression of MHC‐emb declined, as did that of MHC‐neo during the second and third weeks. Correspondingly, the expression of MHC‐IIa, and later, of MHC‐I increased in the secondary fibres. Between the sixth week and second month the expression of MHC‐IIx became prominent. The slow rhomboideus muscle exhibited an early expression of the slow isoform in the secondary fibres. Our results indicate that the timing of muscle maturation depends on its activity immediately following birth. The fastest developing muscle was the diaphragm, followed by the fast muscles. A pronounced changeover from developmental to adult isoforms was noted at 4–6 weeks of age, which coincides with the increased physical activity of puppies.
Pharmacokinetics of intravenous/subcutaneous Enoxaparin in patients with acute coronary syndrome undergoing percutaneous coronary interventions

Plasma anti‐Xa activity after Enoxaparin administration in patients with acute coronary syndrome (ACS) undergoing coronary angiography and percutaneous coronary intervention (PCI) has not been well established. Patients presenting with non–ST‐elevation ACS received an initial dose (0.75 mg/kg) of Enoxaparin intravenously (IV), with subsequent doses (1 mg/kg) subcutaneously (SC) beginning 8 hr following the IV dose. Patients who underwent PCI within 4 hr of the IV dose or 8 hr of the SC dose did not receive additional Enoxaparin. All others received 0.3–0.4 mg/kg additional IV Enoxaparin at the time of PCI. All patients undergoing PCI received a glycoprotein IIb/IIIa inhibitor and clopidogrel. Mean plasma anti‐Xa activity (units/ml) 10 min and 2, 4, 6, and 8 hr after IV dose was 2.29 ± 0.39, 0.99 ± 0.29, 0.58 ± 0.14, 0.36 ± 0.13, 0.24 ± 0.11, respectively. Mean Plasma anti‐Xa activity 2, 4, 6, 8, 10, and 12 hr after SC dose was 1.01 ± 0.22, 1.13 ± 0.27, 1.1 ± 0.41, 0.84 ± 0.19, 0.62 ± 0.24, and 0.46 ± 0.21, respectively. Mean plasma anti‐Xa activity at the start and end of PCI was 1.27 ± 0.41 and 1.07 ± 0.42, respectively. In conclusion, adequate anticoagulation with Enoxaparin may be achieved within 10 min after an IV dose of 0.75 mg/kg. High‐risk ACS patients requiring urgent PCI may benefit from this approach. PCI may be performed without additional anticoagulation within 4 hr of IV or 8 hr of SC Enoxaparin. PCI 4–8 hr after IV dose or 8–12 hr after SC dose will require additional IV Enoxaparin 0.3–0.4 mg/kg to ensure therapeutic anti‐Xa activity. Cathet Cardiovasc Intervent 2002;57:187–190. © 2002 Wiley‐Liss, Inc.
Time Difference Estimation Based on Blind Beamforming for Wideband Emitter

SUMMARY In the localization systems based on time di ﬀ erence of ar- rival (TDOA), multipath fading and the interference source will deteriorate the localization performance. In response to this situation, TDOA estima- tion based on blind beamforming is proposed in the frequency domain. An additional constraint condition is designed for blind beamforming based on maximum power collecting (MPC). The relationship between the weight coe ﬃ cients of the beamformer and TDOA is revealed. According to this relationship, TDOA is estimated by discrete Fourier transform (DFT). The e ﬃ ciency of the proposed estimator is demonstrated by simulation results.
Short‐, middle‐ and long‐term safety of superparamagnetic iron oxide‐labeled allogeneic bone marrow stromal cell transplantation in rat model of lacunar infarction

Recently, both basic and clinical studies demonstrated that bone marrow stromal cell (BMSC) transplantation therapy can promote functional recovery of patients with CNS disorders. A non‐invasive method for cell tracking using MRI and superparamagnetic iron oxide (SPIO)‐based labeling agents has been applied to elucidate the behavior of transplanted cells. However, the long‐term safety of SPIO‐labeled BMSCs still remains unclear. The aim of this study was to investigate the short‐, middle‐ and long‐term safety of the SPIO‐labeled allogeneic BMSC transplantation. For this purpose, BMSCs were isolated from transgenic rats expressing green fluorescent protein (GFP) and were labeled with SPIO. The Na/K ATPase pump inhibitor ouabain or vehicle was stereotactically injected into the right striatum of wild‐type rats to induce a lacunar lesion (n = 22). Seven days after the insult, either BMSCs or SPIO solution were stereotactically injected into the left striatum. A 7.0‐Tesla MRI was performed to serially monitor the behavior of BMSCs in the host brain. The animals were sacrificed after 7 days (n = 7), 6 weeks (n = 6) or 10 months (n = 9) after the transplantation. MRI demonstrated that BMSCs migrated to the damage area through the corpus callosum. Histological analysis showed that activated microglia were present around the bolus of donor cells 7 days after the allogeneic cell transplantation, although an immunosuppressive drug was administered. The SPIO‐labeled BMSCs resided and started to proliferate around the route of the cell transplantation. Within 6 weeks, large numbers of SPIO‐labeled BMSCs reached the lacunar infarction area from the transplantation region through the corpus callosum. Some SPIO nanoparticles were phagocytized by microglia. After 10 months, the number of SPIO‐positive cells was lower compared with the 7‐day and 6‐week groups. There was no tumorigenesis or severe injury observed in any of the animals. These findings suggest that BMSCs are safe after cell transplantation for the treatment of stroke.
Three-dimensional effects in hovering flapping flight

Abstract This paper aims at understanding the influence of three-dimensional effects in hovering flapping flight. Numerical simulations at a Reynolds number of 1000 are performed to compare two types of flapping kinematics whose plunging phase is characterized by either a rectilinear translation or a revolving motion. In this way, we are able to isolate the three-dimensional effects induced by the free end condition from that induced by the spanwise incident velocity gradient (and the associated implicit Coriolis and centrifugal effects). In the rectilinear translation case, the analysis of the wake and of the aerodynamic loads reveals that the wingspan can be compartmented into three distinct regions whether it is predominantly subjected to an unstable two-dimensional flow, a stable three-dimensional flow or both two-dimensional and three-dimensional effects. It is found that this partitioning exhibits common features for three different aspect ratios of the wing. In conjunction with the previous results of Ringuette, Milano & Gharib (J. Fluid Mech., vol. 581, 2007, pp. 453–468), this suggests that the influence of the tip vortex over the wingspan is driven by a characteristic length scale. In addition, this length scale matches the position of the connecting point between leading and tip vortices observed in the revolving case, providing insight into the connecting process. In both translating and revolving cases, leading edge vortex attachment and strong spanwise velocities are found to be strongly correlated phenomena. Spanwise velocities (that mostly confine at the periphery of the vortices), together with downward velocities, do not only affect the leading edge vortex but also act as an inhibitor for the trailing edge vortex growth. As a consequence, cross-wake interactions between leading and trailing edge vortices are locally limited, hence contributing to flow stabilization.
The emission line properties of gravitationally lensed 1.5 < z < 5 galaxies

We present and analyse near-infrared spectroscopy for a sample of 28 gravitationally lensed star-forming galaxies in the redshift range 1.5 < z < 5, observed mostly with the Keck II telescope. With typical magnifications of ≃1.5–4 mag, our survey provides a valuable census of star formation rates, gas-phase metallicities and dynamical masses for a representative sample of low-luminosity galaxies seen at a formative period in cosmic history. We find less evolution in the mass–metallicity relation compared to earlier work that focused on more luminous systems with z ~ 2–3, especially in the low mass (~10^9 M_⊙) where our sample is ~0.25 dex more metal-rich. We interpret this offset as a result of the lower star formation rates (typically a factor of ~10 lower) for a given stellar mass in our subluminous systems. Taking this effect into account, we conclude our objects are consistent with a fundamental metallicity relation recently proposed from unlensed observations.
The Changes in Pulse Pressure Variation or Stroke Volume Variation After a “Tidal Volume Challenge” Reliably Predict Fluid Responsiveness During Low Tidal Volume Ventilation*

Objectives: Stroke volume variation and pulse pressure variation do not reliably predict fluid responsiveness during low tidal volume ventilation. We hypothesized that with transient increase in tidal volume from 6 to 8 mL/kg predicted body weight, that is, “tidal volume challenge,” the changes in pulse pressure variation and stroke volume variation will predict fluid responsiveness. Design: Prospective, single-arm study. Setting: Medical-surgical ICU in a university hospital. Patients: Adult patients with acute circulatory failure, having continuous cardiac output monitoring, and receiving controlled low tidal volume ventilation. Interventions: The pulse pressure variation, stroke volume variation, and cardiac index were recorded at tidal volume 6 mL/kg predicted body weight and 1 minute after the “tidal volume challenge. ” The tidal volume was reduced back to 6 mL/kg predicted body weight, and a fluid bolus was given to identify fluid responders (increase in cardiac index > 15%). The end-expiratory occlusion test was performed at tidal volumes 6 and 8 mL/kg predicted body weight and after reducing tidal volume back to 6 mL/kg predicted body weight. Results: Thirty measurements were obtained in 20 patients. The absolute change in pulse pressure variation and stroke volume variation after increasing tidal volume from 6 to 8 mL/kg predicted body weight predicted fluid responsiveness with areas under the receiver operating characteristic curves (with 95% CIs) being 0.99 (0.98–1.00) and 0.97 (0.92–1.00), respectively. The best cutoff values of the absolute change in pulse pressure variation and stroke volume variation after increasing tidal volume from 6 to 8 mL/kg predicted body weight were 3.5% and 2.5%, respectively. The pulse pressure variation, stroke volume variation, central venous pressure, and end-expiratory occlusion test obtained during tidal volume 6 mL/kg predicted body weight did not predict fluid responsiveness. Conclusions: The changes in pulse pressure variation or stroke volume variation obtained by transiently increasing tidal volume (tidal volume challenge) are superior to pulse pressure variation and stroke volume variation in predicting fluid responsiveness during low tidal volume ventilation.