Miracle-dz/UniFAR-FTUs huggingface dataset:
The Influence of Financial and Social Motives in the Sharing Economy: An Empirical Analysis on Airbnb

The motivation to share has lately been investigated in the sharing economy literature. This study extends this literature by exploring the role of economic and social drivers from the accommodation providers’ perspective on the sharing economy platform Airbnb. In doing so, we contribute to the sharing economy literature by compartmentalizing the two-sided consumer market. Furthermore, we respond to the emerging call for understanding the motivational factors under which trust operates in the sharing economy context. Specifically, this article introduces two key moderators, financial motives and social motives, to the relationship between trust and the intention to share an accommodation. Drawing on the theory of trust and based on a dataset of 203 participants, we find that financial motives positively moderate the relationship between trust in renters and the intention to share an accommodation, whereas social motives show no significant influence on the same relationship.
Investigating antecedents and moderating factors of consumer's acceptance and adoption of online-received recommendations on social media: an empirical analysis

The topic of Electronic Word-of-Mouth (eWOM) has received considerable attention in both academia and among business practitioners. Yet, despite an emerging literature on the effectiveness of eWOM communication, 'the scope of published studies on the impact of eWOM communication is rather broad, and the studies appear relatively fragmented and inconclusive'. Integrating the elaboration likelihood model, network theory, and the concept of consumer innovativeness, this study focuses on the topic of 'online-received recommendations' on social media platforms. The theoretical model is then tested using partial least squares method. Based on an online survey distributed on social networks the results indicate that argument quality, perceptual affinity and information usefulness are determinants that influence the adoption of online-received recommendations. Managers can capitalise these results by designing information with a high degree of argument quality in order to enhance the perceived usefulness, thereby triggering the adoption of the information.
Profile of Fishermen Migration in Nigeria and Implications for a Sustainable Livelihood

Limited documentation exists on migrant fishermen, who are indigenous people and mostly Ghanaians fishing in the marine and inland water bodies. This study therefore aims to identify the causes, courses of fishermen migration as well as the demographic characteristics of migrant fishing households in the Nigerian South West coastal fishing communities using the neoclassical economic and network theories. Results reveal that they operate extended family system similar to what operates in their places of origin. The main cause of fishermen migrating from other West African countries to Nigeria is due to seasonal migration of commercial fish species and some of the migrants have permanently settled in the fishing communities. Logit model analysis shows that migrant fishermen are likely to be located in the west coast of Lagos State (p<0.01). Migrant fishermen have fishing as a primary source of income (p<0.05), are members of fishermen cooperatives (p<0.05) and are likely to be literate (p<0.10), but do not use family labour (p<0.05). Due to migration they are confronted with challenges such as declining fish stocks, attitude to management of common property resource, living communities which lack basic infrastructures and the prevalence of HIV/AIDS.
The NF (Nuclear factor)‐κB inhibitor parthenolide interacts with histone deacetylase inhibitors to induce MKK7/JNK1‐dependent apoptosis in human acute myeloid leukaemia cells

Interactions between the nuclear factor (NF)‐κB inhibitor parthenolide and the pan‐histone deacetylase inhibitors (HDACIs) vorinostat and LBH589 were investigated in human acute myeloid leukaemia (AML) cells, including primary AML blasts. Co‐administration of parthenolide blocked HDACI‐mediated phosphorylation/activation of IKK and RelA/p65 in association with increased JNK1 activation in various AML cell types. These events were accompanied by an increase in apoptosis in multiple AML cell lines (e.g. U937, HL‐60, NB4, MV‐4‐11, and MOLM‐13). Significantly, parthenolide also increased HDACI‐mediated cell death in haematopoietic cells transduced with the MLL‐MLLT1 fusion gene, which exhibit certain leukaemia‐initiating cell characteristics, as well as primary AML blasts. Exposure to parthenolide/HDACI regimens clearly inhibited the growth of AML‐colony‐forming units but was relatively sparing toward normal haematopoietic progenitors. Notably, blockade of c‐Jun N‐terminal kinase (JNK) signalling by either pharmacological inhibitors or genetic means (e.g. dominant‐negative JNK1 or JNK1 shRNA) diminished parthenolide/HDACI‐mediated lethality. Moreover, dominant‐negative MKK7, but not dominant‐negative MKK4/SEK1, blocked JNK1 activation and apoptosis induced by parthenolide/HDACI regimens. Together, these findings indicate that parthenolide potentiates HDACI lethality in human AML cells through a process involving NF‐κB inhibition and subsequent MKK7‐dependent activation of the SAPK/JNK pathway. They also raise the possibility that this strategy may target leukaemic progenitor cells.
Acoustic detection and satellite-tracking leads to discovery of rare concentration of endangered North Pacific right whales

The North Pacific right whale, Eubalaena japonica, is one of the most endangered species of whale in the world. On 10 August 2004, two right whales were located in the Bering Sea using headings to right whale calls provided by directional sonobuoys. A satellite-monitored radio tag attached to one of these whales functioned for 40 days. Over the 40-day period, this whale moved throughout a large part of the southeast Bering Sea shelf, including areas of the outer-shelf where right whales have not been seen in decades. In September, multiple right whales were acoustically located and subsequently sighted by another survey vessel approaching a near-real-time position from the tag. An analysis of photographs confirmed at least 17 individual whales (not including the tagged whales). Genetic analysis of biopsy samples identified 17 individuals: 10 males and 7 females. The discovery of seven females was significant, as only one female had been identified in the past. Genetics also confirmed the presence of at least two calves. Although the future of this population is highly uncertain, the discovery of additional females and calves gives some hope that this most critically endangered of all whale populations may still possess the capacity to recover.
Cardiovascular responses to active and passive cycling movements.

Ten healthy subjects were evaluated at rest and at 5 min of unloaded active (AC) and passive (PC) cycling. Passive limb movements were accomplished using a tandem bicycle with a second rider performing the movements. We measured heart rate (HR), mean arterial pressure (MAP), cardiac output (CO), oxygen uptake (VO2), rating of perceived exertion (RPE), and electrical activity (EMG) of lower limbs muscles. Values for stroke volume (SV) and peripheral vascular resistance (PVR) were calculated. EMG, RPE, and VO2 were higher during AC than during PC (P < 0.001). CO increased during both modes of cycling, but during AC it resulted from a HR acceleration (73 +/- 2 at rest to 82 +/- 2 beats.min-1 at 60 rpm; P < 0.001) with no change in SV whereas during PC, SV increased from rest (65 +/- 4 at rest to 71 +/- 3 ml at 60 rpm; P = 0.003) along with no change in HR. PVR remained constant during PC, but decreased by 13% during AC (P < 0.001) and MAP increased only during PC (93 +/- 2 at rest to 107 +/- 2 mm Hg at 60 rpm). These results supports the concept that central command determines the HR response to dynamic exercise. The increase in SV and consequently in MAP during PC was probably due to increased venous return and/or to muscle mechanoreceptor-evoked increased myocardial contractility.
Corporate social responsibilities and marketing

In today's competitive market, Corporate Social Responsibility (CSR) is proposed as one of the main and strategic concepts for several companies so that in recent years, 90% of companies that have been among the top 500 companies of Fortune, have used social-responsibility based activities. As the new paradigms of marketing (including third-generation marketing from Kotler's view), the convergence of marketing thought process toward social marketing and issues related to social responsibility show the aim of third-generation marketing is to change the world to the best place for living. Therefore, in this study, a meta-analysis was provided about the impact of CSR on two main areas of marketing namely consumer behavior and corporate marketing. Concerning the consequences of CSR on consumer behavior, it can be referred to issues such as customer-company identification, customer response, customer satisfaction, positive evaluation of product and company, positive attitude toward product and company, acceptation of suggestions, agree to pay more prices by customers, and loyalty, which play a key and effective role on consumer behavior. Regarding the corporate marketing, it can be referred to issues such as the creation of corporate image, better financial performance, the improvement of corporate reputation, the increase of brand equity and market stock value.
Tumor Necrosis Factor–α Promoter −308/238 Polymorphism Association with Less Severe Disease in Ankylosing Spondylitis is Unrelated to Serum TNF-α and Does Not Predict TNF Inhibitor Response

Objective. Despite the clinical efficacy of tumor necrosis factor inhibitors (TNFi), the manner in which TNF-α contributes to disease in patients with ankylosing spondylitis (AS) remains unresolved. We investigated the relationship between TNF-α gene promoter region polymorphism, serum TNF-α levels, and clinical phenotype. Methods. We did a cross-sectional and longitudinal cohort study in TNFi-naive patients with AS (n = 335). Clinical data and biological samples were collected during a research visit with genotyping for TNF-α −238 A/G and −308 A/G performed by Taqman RT-PCR and TNF levels determined by sandwich ELISA. Longitudinal TNF levels were monitored in unselected patients (n = 61). Results. TNF-α −308 GA/AA genotype was present in 14% and TNF-α −238 GA/AA genotype in 1% of patients. TNF-α −308 GA/AA genotype was associated with a reduced risk of uveitis and better spinal function, while TNF-α −238 GA/AA genotype was associated with later age of onset and lower erythrocyte sedimentation rate (ESR). Serum TNF-α level was lower in patients with AS (151 pg/ml) than in controls (263 pg/ml), because more patients with AS had undetectable serum TNF-α (66 vs 25%, p < 0.001). TNFi treatment did not influence serum TNF-α. There was no effect of TNF-α −308/−238 or HLA-B27 genotype on serum TNF-α or subsequent initiation of TNFi. Conclusion. TNF-α −238 or −308 GA/AA genotypes in patients with AS are associated with signs of less severe disease. Serum TNF-α is, however, undetectable in two-thirds of patients with AS and is not influenced by TNF-α promoter genotype or TNFi therapy. These data suggest a more significant role for TNF-α at local sites of inflammation in AS than through systemic effects.
Pathogenesis of Osteopetrosis: A Comparison of Human and Animal Spectra

The term osteopetrosis was introduced to describe a human condition characterized by generalized sclerosis of the skeleton with multiple fractures [l, 401. Subsequently, several isolated reports have described the clinical spectrum of the human disease, genetic variants, and histological correlates in bone. The occurrence in several animal species of diseases involving increased bone density has suggested that satisfactory models of the human disease might exist which would permit evaluation of pathogenic mechanisms under a variety of experimental conditions. This review compares the human forms of the disease with those animal syndromes which have been termed osteopetrosis on the basis of gross and radiological observations.
Botulinum toxin A and chronic low back pain

Objectives: To investigate the efficacy of botulinum toxin A in chronic low back pain and associated disabilities. Methods: Thirty-one consecutive patients with chronic low back pain who met the inclusion criteria were studied: 15 received 200 units of botulinum toxin type A, 40 units/site at five lumbar paravertebral levels on the side of maximum discomfort, and 16 received normal saline. Each patient’s baseline level of pain and degree of disability was documented using the visual analogue scale (VAS) and the Oswestry Low Back Pain Questionnaire (OLBPQ). The authors reevaluated the patients at 3 and 8 weeks (visual analogue scale) and at 8 weeks (OLBPQ). Results: At 3 weeks, 11 of 15 patients who received botulinum toxin (73.3%) had >50% pain relief vs four of 16 (25%) in the saline group (p = 0.012). At 8 weeks, nine of 15 (60%) in the botulinum toxin group and two of 16 (12.5%) in the saline group had relief (p = 0.009). Repeat OLBPQ at 8 weeks showed improvement in 10 of 15 (66.7%) in the botulinum toxin group vs three of 16 (18.8%) in the saline group (p = 0.011). No patient experienced side effects. Conclusion: Paravertebral administration of botulinum toxin A in patients with chronic low back pain relieved pain and improved function at 3 and 8 weeks after treatment.
Awareness and use of social bookmarking services by final year students in a Nigerian private university

Social computing is one of the renascent features of the web that has made it highly interactive. One of such social tools in the web is the social bookmarking services. It has been reported that social bookmarking services may be the least known social media network by students. Given that social media has been predicted to revolutionize learning it is therefore imperative to study the awareness and use of social media tools like social bookmarking services by undergraduate students. The survey research design was employed and questionnaire used to collect data. Using the SPSS statistical tool, the data were analysed and the result presented in simple percentages. It was found that the students are largely (60.9%) not aware of social bookmarking services. Their familiarity with and usage of the services were very low as very little proportions of the respondents can either “use”, “are using” or “have used” some of the social bookmarking services. With 28%, meeting people with similar research interest is the most beneficial feature of social bookmarking services to the students. But overall, the students (52.2%) agree that social bookmarking services are useful for their academic work. Keywords: social bookmarking, social media, undergraduate students, private university
Sleep duration or bedtime? Exploring the relationship between sleep habits and weight status and activity patterns.

STUDY OBJECTIVES To assess the effects of early and late bedtimes and wake up times on use of time and weight status in Australian school-aged children. DESIGN Observational cross-sectional study involving use of time interviews and pedometers. SETTING Free-living Australian adolescents. PARTICIPANTS 2200 9- to 16-year-olds from all states of Australia INTERVENTIONS NA. MEASUREMENTS AND RESULTS Bedtimes and wake times were adjusted for age and sex and classified as early or late using median splits. Adolescents were allocated into 4 sleep-wake pattern groups: Early-bed/Early-rise; Early-bed/Late-rise; Late-bed/Early-rise; Late-bed/Late-rise. The groups were compared for use of time (screen time, physical activity, and study-related time), sociodemographic characteristics, and weight status. Adolescents in the Late-bed/Late-rise category experienced 48 min/d more screen time and 27 min less moderate-to-vigorous physical activity (MVPA) (P<0.0001) than adolescents in the Early-bed/Early-rise category, in spite of similar sleep durations. Late-bed/Late-rise adolescents had a higher BMI z-score (0.66 vs. 0.45, P=0.0015). Late-bed/Late-rise adolescents were 1.47 times more likely to be overweight or obese than Early-bed/Early-rise adolescents, 2.16 times more likely to be obese, 1.77 times more likely to have low MVPA, and 2.92 times more likely to have high screen time. Late-bed/Late-rise adolescents were more likely to come from poorer households, to live in major cities, and have fewer siblings. CONCLUSIONS Late bedtimes and late wake up times are associated with an unfavorable activity and weight status profile, independent of age, sex, household income, geographical remoteness, and sleep duration.
Supporting Children on the Autism Spectrum in Peer Play at Home and School

The article focuses on integrated play groups (IPGs) as a model to support children with ASD in play with typically developing peers/siblings, and its recent adoption with children in a home and school setting in Taiwan. The first part provides a brief overview of the IPG model and its essential features. The second part reports on a pilot investigation that combined quantitative and qualitative methods to examine the effects of participation in IPGs on the symbolic and social play of two early elementary-aged children with autism. Preliminary findings suggest that each child made notable gains in reciprocal social interaction and symbolic/pretend play while participating in play groups. Implications are discussed in terms of play’s role in enhancing socialization, imagination and peer cultural inclusion.
Diabetes mellitus and its treatment

Diabetes mellitus (DM) is a metabolic disorder resulting from a defect in insulin secretion, insulin action, or both. Insulin deficiency in turn leads to chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism. It is the most common endocrine disorder and by the year 2010, it is estimated that more than 200 million people worldwide will have DM and 300 million will subsequently have the disease by 2025. As the disease progresses tissue or vascular damage ensues leading to severe diabetic complications such as retinopathy, neuropathy, nephropathy, cardiovascular complications and ulceration. Thus, diabetes covers a wide range of heterogeneous diseases. Diabetes mellitus may be categorized into several types but the two major types are type 1 and type 2. Drugs are used primarily to save life and alleviate symptoms. Secondary aims are to prevent long-term diabetic complications and, by eliminating various risk factors, to increase longevity. Insulin replacement therapy is the mainstay for patients with type 1 DM while diet and lifestyle modifications are considered the cornerstone for the treatment and management of type 2 DM. Insulin is also important in type 2 DM when blood glucose levels cannot be controlled by diet, weight loss, exercise and oral medications. Oral hypoglycaemic agents are also useful in the treatment of type 2 DM. Oral hypoglycaemic agents include sulphonylureas, biguanides, alpha glucosidase inhibitors, meglitinide analogues, and thiazolidenediones. The main objective of these drugs is to correct the underlying metabolic disorder, such as insulin resistance and inadequate insulin secretion. They should be prescribed in combination with an appropriate diet and lifestyle changes. Diet and lifestyle strategies are to reduce weight, improve glycaemic control and reduce the risk of cardiovascular complications, which account for 70% to 80% of deaths among those with diabetes. Diabetes is best controlled either by diet alone and exercise (non-pharmacological), or diet with herbal or oral hypoglycaemic agents or insulin (pharmacological). The main side effects are weight gain and hypoglycaemia with sulfonylureas, gastrointestinal (GI) disturbances with metformin, weight gain, GI disturbances and liver injury with thiazolidinediones, GI disturbances, weight gain and hypersensitivity reactions with meglitinides and flatulence, diarrhoea and abdominal bloating with alpha-glucosidase inhibitors. (Int J Diabetes Metab 13:111-134, 2005)
Rescue of CAMDI deletion‐induced delayed radial migration and psychiatric behaviors by HDAC6 inhibitor

The DISC1‐interacting protein CAMDI has been suggested to promote radial migration through centrosome regulation. However, its physiological relevance is unclear. Here, we report the generation and characterization of CAMDI‐deficient mice. CAMDI‐deficient mice exhibit delayed radial migration with aberrant neural circuit formation and psychiatric behaviors including hyperactivity, repetitive behavior, and social abnormality typically observed in autism spectrum disorder patients. Analyses of direct targets of CAMDI identify HDAC6 whose α‐tubulin deacetylase activity is inhibited by CAMDI at the centrosome. CAMDI deficiency increases HDAC6 activity, leading to unstable centrosomes with reduced γ‐tubulin and acetylated α‐tubulin levels. Most importantly, psychiatric behaviors as well as delayed migration are significantly rescued by treatment with Tubastatin A, a specific inhibitor of HDAC6. Our findings indicate that HDAC6 hyperactivation by CAMDI deletion causes psychiatric behaviors, at least in part, through delayed radial migration due to impaired centrosomes.
DESICCATION TOLERANCE AND DNA INTEGRITY IN Eugenia pleurantha O. Berg. (MYRTACEAE) SEEDS 1

The aim of this study was to assess the desiccation tolerance and DNA integrity in Eugenia pleurantha seeds dehydrated to different moisture contents (MCs). Seeds extracted from mature fruits were submmited to drying in silica gel and evaluated at every five percentual points of decrease from the initial MC (35.5%, fresh weight basis). The effects of dehydration on seeds were verified through germination tests and DNA integrity assessment. Undried seeds achieved 87% germination, value reduced to 36% after being dried to 9.8% MC. When dried slightly more, to 7.4% MC, seeds were no longer able to germinate, suggesting an intermediate behavior in relation to desiccation tolerance. It was observed DNA degradation in seeds with 7.4% MC, which might have contributed to the loss of seed germination.
Competition, Value Creation and the Self-Understanding of Business

In defense of his Market Failures Approach to business ethics Joseph Heath relies on an understanding of business as essentially oriented towards competition and profit maximization. In these remarks I defend an alternative understanding of business that is centered on the creation of valuable goods and services. It is preferable because it: (a) creates less pressure to take advantage of vulnerable stakeholders, (b) can readily recognize “beyond compliance” norms that do not relate to efficiency, (c) provides a more meaningful framework for people who work in and with corporations, (d) may mitigate negative moral impacts outside the market, and (e) better captures the range of what actually counts as business activity. JOSEPH HEATH’S MARKET Failures Approach to business ethics (MFA) holds that firms should engage in profit-oriented competition, except when the actual market fails to deliver desired efficiencies. In these cases businesses should engage in self-restraint to not take adUniversity of British Columbia. Email: david.silver@sauder.ubc. ca 1 ____________________________________________ Discuss this commentary at http://bejr.co/2016-0410x Cite as: Bus Ethics J Rev 4(10): 59–65, http://doi.org/10.12747/bejr2016.04. 10 Edited by Chris MacDonald & Alexei Marcoux