Miracle-dz/UniFAR-FTUs huggingface dataset:
Metastatic melanoma in a 95 years old patient responding to treatment with talimogene laherparepvec followed by nivolumab

thrombosis and bile duct stenosis after stereotactic body radiation therapy for hepatocellular carcinoma. Hepatol Res. 2014;44:E278. [11] Nery F, Chevret S, Condat B, et al. Causes and consequences of portal vein thrombosis in 1,243 patients with cirrhosis: results of a longitudinal study. Hepatology. 2015;61:660–667. [12] Harding DJ, Perera MT, Chen F, et al. Portal vein thrombosis in cirrhosis: controversies and latest developments. World J Gastroenterol. 2015;21:6769. [13] Seppenwoolde Y, Wunderink W, Wunderink-van Veen SR, et al. Treatment precision of image-guided liver SBRT using implanted fiducial markers depends on marker-tumour distance. Phys Med Biol. 2011;56:5445. [14] Chan MKH, Lee V, Chiang CL, et al. Lipiodol versus diaphragm in 4D-CBCT-guided stereotactic radiotherapy of hepatocellular carcinomas. Strahlenther Onkol. 2016;192:92–101. [15] Szeto A, Chin L, Whelan P, et al. Image-guided radiation therapy using surgical clips for localization of colonic metastasis from thyroid cancer. Radiat Oncol. 2014;9:298. [16] Anantharaju A, Van Thiel DH. Liver transplantation for alcoholic liver disease. Alcohol Res Health. 2003;27:257–268.
Surgical Versus Endovascular Reconstruction for Chronic Mesenteric Ischemia: A Contemporary UK Series

Objective: To assess the outcome of surgical (SR) and endovascular (ER) reconstruction for chronic mesenteric ischemia (CMI). Methods: Retrospective review of consecutive patients who underwent SR or ER for CMI in 3 UK vascular surgery units between 1996 and 2006. Early (<30 days; technical success, morbidity, mortality, length of hospital stay) and late (>30 days) outcomes (symptom recurrence, vessel/graft patency, reintervention, mortality) were assessed. Results: A total of 27 patients underwent 32 reconstructions (SR = 17, ER = 15). A total of 44 of 56 (79%) diseased arteries underwent SR (n = 26; bypass = 24, reimplantation = 2; occlusion = 16, stenosis = 10) or ER (n = 18; stenosis = 16, occlusion = 2). Perioperative mortality for SR and ER was 6% and 0%, respectively (P ≥ .99). Hospital stay was shorter following ER (mean, 4.3 vs. 14.2 days, P = .0003). Mean (range) follow-up for SR and ER was 34 (1-94) and 34 (0-135) months, respectively. At 2 years, SR demonstrated superior secondary patency (100% vs. 65%) and clinical patency (100% vs. 73%). Conclusions: Surgical mesenteric reconstruction is associated with significantly longer hospital stay, but superior long-term outcome compared to endovascular reconstruction.
WHAT: A novel routing metric for multi-hop cognitive wireless networks

In this paper, we study how to select a high performance end-to-end path in multi-hop cognitive wireless networks. Due to the time-varying spectrums and undetermined activity of primary users, path selection in cognitive wireless networks is much harder than that of traditional wireless networks. To attack this problem, we propose a novel routing metric, called WHAT (Weighted Hop, spectrum-Awareness, and sTability), which takes not only opportunistic spectrum access into account, but also path stability. WHAT synthesizes channel switching frequency, usage of licensed channels, and length of path together to evaluate the overall quality of an end-to-end path. In addition, different from some existing routing metrics, WHAT has two key properties of routing metric: isotonicity and monotonicity. The theoretical analysis and simulation results show that WHAT can improve the network performance (TCP throughput) profoundly and ensure routing protocols operate correctly.
A taxometric investigation of the latent structure of social anxiety disorder in outpatients with anxiety and mood disorders

The latent structure of social phobia was examined in a sample of 2,035 outpatients with anxiety and mood disorders to determine whether the disorder operates in a categorical or dimensional fashion. We performed three mathematically distinct taxometric procedures—MAMBAC, MAXEIG, and L‐Mode—using five indicators constructed from clinical interview ratings and questionnaire measures of social anxiety symptoms. Results from screening analyses and simulated comparison data consistently indicated that the data were suitable for taxometric analysis. The collective results across procedures, consistency tests, and analysis of simulated comparison data produced converging evidence in support of the conclusion that the latent structure of social phobia is dimensional. Depression and Anxiety 23:190–199, 2006. © 2006 Wiley‐Liss, Inc.
Recombination Is Surprisingly Constructive for Artificial Gene Regulatory Networks in the Context of Selection for Developmental Stability

Recombination is ubiquitous in multicellular plants, animals and even fungi. Many studies have shown that recombination can generate a great amount of genetic innovations, but it is also believed to damage well-adapted lineages, causing debates over how organisms cope with such disruptions. Using an established model of artificial gene regulatory networks, here we show that recombination may not be as destructive as expected. Provided only that there is selection for developmental stability, recombination can establish and maintain lineages with reliably better phenotypes compared to asexual reproduction. Contrary to expectation, this does not appear to be a simple side effect of higher levels of variation. A simple model of the underlying dynamics demonstrates a surprisingly high robustness in these lineages against the disruption caused by recombination. Contrary to expectation, lineages subject to recombination are less likely to produce offspring suffering truncation selection for instability than asexual lineages subject to simple mutation. These findings indicate the fundamental differences between recombination and high mutation rates, which has important implications for understanding both biological innovation and hierarchically structured models of machine learning.
Sirolimus in pediatric patients: Results in the first 6 months post‐renal transplant

Abstract: We report our experience with sirolimus in children during the first 6 months after renal transplantation. From July 2000 to January 2004, 66 children received 33 deceased donor and 33 living donor transplants. Maintenance immunosuppression included sirolimus 3 mg/m2 in addition to prednisone and tacrolimus or cyclosporine. Patient survival was 100% and graft survival was 65 of 66. Seven children experienced acute rejection episodes. All were reversible with increased doses of corticosteroid. One case of graft failure was caused by ischemic renal injury. Adverse events included Epstein–Barr viremia (8 patients) with three cases of post‐transplant lymphoproliferative disease (PTLD), cytomegalovirus viremia (4 patients), poor wound healing (4 patients), pneumonitis (3 patients), nephrotic syndrome (3 patients), perinephric abscess (1 patient) and insulin‐dependant diabetes (2 patients). Sirolimus was discontinued in 13 children for adverse events predominantly for wound dehiscence and pneumonitis. Cholesterol levels >200 mg/dL were observed in 33 children. Thrombocytopenia (platelet count <140 000) was not observed. We concluded that early outcomes with sirolimus were acceptable with 98% graft survival and 11% incidence of acute rejection. Medication was discontinued in 20% for adverse events which included poor wound healing and non‐infectious pneumonitis. Infections with cytomegalovirus and Epstein–Barr virus, and PTLD were also significant early complications. Therefore, a sirolimus‐based regimen that is combined with both an interleukin‐2 receptor antibody and a calcineurin inhibitor may be excessive immunosuppression for pediatric renal transplant recipients.
The Real Estate Risk Premium Puzzle: A Solution 1

For decades, performance comparisons between real estate and financial assets have repeatedly indicated that private real estate investment exhibits significantly higher risk-adjusted returns than publicly traded financial assets such as common stocks. That is, there is an apparent “real estate risk premium puzzle. ” In this paper, we find that the seemingly superior risk-adjusted returns of real estate may be caused by inappropriate adoption of the conventional risk measure to real estate, a measure that completely ignores the non-i.i. d. nature of the asset’s return distribution, as well as its illiquidity risk. We develop a modified performance measure—a Sharpe ratio for real estate—to capture the time-dependent nature of real estate risk by incorporating illiquidity risk in a closed-form formula. Our finding shows that, once the real estate risk is properly measured, the longstanding “real estate risk premium puzzle” no longer exists. Our approach also shows that real estate price risk over time can be accurately obtained through empirical estimation without relying on a simplification assumption of a particular distribution like the i.i. d. assumption.
Genetic Analysis of the Role of Peroxisomes in the Utilization of Acetate and Fatty Acids in Aspergillus nidulans

Peroxisomes are organelles containing a diverse array of enzymes. In fungi they are important for carbon source utilization, pathogenesis, development, and secondary metabolism. We have studied Aspergillus nidulans peroxin (pex) mutants isolated by virtue of their inability to grow on butyrate or by the inactivation of specific pex genes. While all pex mutants are able to form colonies, those unable to import PTS1 proteins are partially defective in asexual and sexual development. The pex mutants are able to grow on acetate but are affected in growth on fatty acids, indicating a requirement for the peroxisomal localization of β-oxidation enzymes. However, mislocalization of malate synthase does not prevent growth on either fatty acids or acetate, showing that the glyoxylate cycle does not require peroxisomal localization. Proliferation of peroxisomes is dependent on fatty acids, but not on acetate, and on PexK (Pex11), expression of which is activated by the FarA transcription factor. Proliferation was greatly reduced in a farAΔ strain. A mutation affecting a mitochodrial ketoacyl-CoA thiolase and disruption of a mitochondrial hydroxy-acyl-CoA dehydrogenase gene prevented growth on short-chain but not long-chain fatty acids. Together with previous results, this is consistent with growth on even-numbered short-chain fatty acids requiring a mitochondrial as well as a peroxisomal β-oxidation pathway. The mitochondrial pathway is not required for growth on valerate or for long-chain fatty acid utilization.
Automatic assessment of children speech to support language learning

Focus of this work are pattern recognition related aspects of computer assisted pronunciation training (CAPT) for second language learning. An overview of commercial systems shows that pronunciation training is being addressed by the growing eld of computer assisted language learning only to a small extend, although in the state-of-the-art section a number of such approaches for automatic assessment can already be presented. In the present thesis di erent approaches are extended and combined. In particular a large set of nearly 200 pronunciation and prosodic features is developed. By this approach pronunciation scoring is regarded as classi cation task in high-dimensional feature space. Automatic speech recognition is the basis of most pronunciation scoring algorithms. In this thesis a system is presented, which supports second language learning in school, i.e. the target users are children. For this reason a state-of-the-art speech recognition engine is adapted to children speech, since young speakers are only hardly recognised by automatic systems. Phonetically motivated rules for typical mispronunciation errors are integrated into the system to make it suitable for pronunciation scoring. Evaluating an algorithm for pronunciation assessment is more di cult than simply counting the correctly recognised mistakes, since there exists no objective ground truth. This can be shown by evaluating the annotations of 14 teachers. However, with di erent measures it can be veri ed that the accuracy of the system (in comparison with teachers) thoroughly reaches the agreement among teachers. The evaluation is conducted with native German speakers learning English.
Algebraic solution for the vector potential in the Dirac equation

The Dirac equation for an electron in an external electromagnetic field can be regarded as a singular set of linear equations for the vector potential. Radford’s method of algebraically solving for the vector potential is reviewed, with attention to the additional constraints arising from non-maximality of the rank. The extension of the method to general spacetimes is illustrated by examples in diverse dimensions with both c- and a-number wavefunctions. PACS numbers: 0350D, 0210, 0220, 0365P, 1130P
Relationships of barriers and facilitators to breast self‐examination, mammography, and clinical breast examination in a worksite population

The American Cancer Society recommends a regimen for breast cancer screening that includes mammograms, clinical breast examination, and breast self-examination. Compliance with breast cancer screening guidelines has been linked to a number of barriers and facilitators. These barriers and facilitators seem to lie within the cognitive framework and generalized beliefs of women, and in the situational contexts in which they lead their lives. A comprehensive study was designed to investigate variables related to breast cancer screening behaviors (breast self-examination, mammography, and clinical breast examination) of working women ≥ 35 years of age at their worksite environments. A factor analysis identified similar sets of composite variables related to each of the screening modalities, and a discriminant analysis was performed for each screening technique to identify those variables that were most significant in predicting compliance with screening guidelines. The variables discomfort, perceived efficacy, and desire for control over health were significant for all three screening behaviors. Perceived importance was identified as a fourth variable for mammography and clinical breast examination, and lack of knowledge was a fourth variable for breast self-examination. Effective breast cancer screening programs involve all three screening techniques. In the design of education and intervention programs at worksites, it is critical to emphasize the commonalities of the variables that emerged in this study as important for each screening technique.
A Provably Secure, Efficient, and Flexible Authentication Scheme for Ad hoc Wireless Sensor Networks

In 2014, Turkanovic et al. proposed a smart card-based authentication scheme for heterogeneous ad hoc wireless sensor network. This scheme is very efficient since it employs only hash function and XOR operation. However, we found that Turkanovic et al.'s scheme is vulnerable to impersonation attack with node capture, stolen smart card attack, sensor node spoofing attack, stolen verifier attack, and fails to ensure backward secrecy. We propose an efficient scheme to overcome all those weaknesses. Moreover, we also propose an advanced scheme, which provides perfect forward secrecy without much modification from the first proposed scheme.
Solubility of Budesonide , Hydrocortisone , and Prednisolone in Ethanol + Water Mixtures at 298 . 2 K

Address: 1Institute of Pharmaceutical Innovation, University of Bradford, Richmond Rd., Bradford, BD7 1DP, U.K., 2Department of Pharmaceutics, Pharmacy Faculty, Assiut University, Assiut 71515, Egypt, 3Biotechnology Research Center and Pharmacy, Faculty and Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz 51664, Iran, 4Department of Chemistry, University of North Texas, Denton, Texas 76203-5070, 5Pharmacy Faculty and Drug Applied Research Center, Tabriz University
Helical computed tomography of bowel and mesenteric injuries.

BACKGROUND The role of computed tomography in diagnosing hollow viscus injury after blunt abdominal trauma remains controversial, with previous studies reporting both high accuracy and poor results. This study was performed to determine the diagnostic accuracy of helical computed tomography in detecting bowel and mesenteric injuries after blunt abdominal trauma in a large cohort of patients. METHODS One hundred fifty patients were admitted to our Level I trauma center over a 4-year period with computed tomographic (CT) scan or surgical diagnosis of bowel or mesenteric injury. CT scan findings were retrospectively graded as negative, nonsurgical, or surgical bowel or mesenteric injury. The CT scan diagnosis was then compared with surgical findings, which were also graded as negative, nonsurgical, or surgical. RESULTS Computed tomography had an overall sensitivity of 94% in detecting bowel injury and 96% in detecting mesenteric injury. Surgical bowel cases were correctly differentiated in 64 of 74 cases (86%), and surgical mesenteric cases were correctly differentiated from nonsurgical in 57 of 76 cases (75%). CONCLUSION Helical CT scanning is very accurate in detecting bowel and mesenteric injuries, as well as in determining the need for surgical exploration in bowel injuries. However, it is less accurate in predicting the need for surgical exploration in mesenteric injuries alone.
Low concentration of lipopolysaccharide acts on MC3T3‐E1 osteoblasts and induces proliferation via the COX‐2‐independent NFκB pathway

The translocations of lipopolysaccharide (LPS) from the gut and its effects on bone healing are usually of clinical interest during bone fracture. As already widely stuided, Cyclooxygenase‐2 (COX‐2) is a key enzyme for prostaglandin E2 (PGE2) production, which induces the nuclear factor kappa B (NFκB) activation and is beneficial to fracture healing. In order to know their roles in skeletal regeneration, mouse MC3T3‐E1 osteoblasts were treated with NFκB inhibitor BAY 11‐7082 and sc791 (a selective COX‐2 inhibitor), in the presence of LPS. Interestingly, LPS could induce osteoblasts proliferation through increasing NFκB activation and translocation. This induction was not related to COX‐2 expression, suggesting that LPS‐induced NFκB activiation is independent of COX‐2. It is possible that low concentration of LPS can act as a stimulating factor of the NFκB pathway in nonstimulated cells such as osteoblasts. COX‐2 is not necessary for the NFκB pathway during LPS‐induced proliferation of osteoblasts since sc791 had no effects on this induction. These studies provide insight into a potential mechanism by which LPS can affect bone tissue repair in the initial phase of inflammation. Copyright © 2009 John Wiley & Sons, Ltd.
Institutional profile: University of Florida and Shands Hospital Personalized Medicine Program: clinical implementation of pharmacogenetics.

The University of Florida and Shands Hospital recently launched a genomic medicine program focused on the clinical implementation of pharmacogenetics called the Personalized Medicine Program. We focus on a pre-emptive, chip-based genotyping approach that is cost effective, while providing experience that will be useful as genomic medicine moves towards genome sequence data for patients becoming available. The Personalized Medicine Program includes a regulatory body that is responsible for ensuring that evidence-based examples are moved to clinical implementation, and relies on clinical decision support tools to provide healthcare providers with guidance on use of the genetic information. The pilot implementation was with CYP2C19–clopidogrel and future plans include expansion to additional pharmacogenetic examples, along with aiding in implementation in other health systems across Florida.
S-Nitrosylating Agents: A Novel Class of Compounds That Increase Cystic Fibrosis Transmembrane Conductance Regulator Expression and Maturation in Epithelial Cells

The endogenous bronchodilator, S-nitrosoglutathione (GSNO), increases expression, maturation, and function of both the wild-type and the ΔF508 mutant of the cystic fibrosis transmembrane conductance regulatory protein (CFTR). Though transcriptional mechanisms of action have been identified, GSNO seems also to have post-transcriptional effects on CFTR maturation. Here, we report that 1) GSNO is only one of a class of S-nitrosylating agents that, at low micromolar concentrations, increase ΔF508 and wild-type CFTR expression and maturation; 2) NO itself (at these concentrations) and 8-bromocyclic GMP are minimally active on CFTR; 3) a novel agent, S-nitrosoglutathione diethyl ester, bypasses the need for GSNO bioactivation by γ-glutamyl transpeptidase to increase CFTR maturation; 4) surprisingly, expression—but not S-nitrosylation—of cysteine string proteins (Csp) 1 and 2 is increased by GSNO; 5) the effect of GSNO to increase full maturation of wild-type CFTR is inhibited by Csp silencing (si)RNA; 6) proteins relevant to CFTR trafficking are SNO-modified, and SNO proteins traffic through the endoplasmic reticulum (ER) and Golgi after GSNO exposure; and 7) GSNO alters the interactions of ΔF508 CFTR with Csp and Hsc70 in the ER and Golgi. These data suggest that GSNO is one of a class of S-nitrosylating agents that act independently of the classic NO radical/cyclic GMP pathway to increase CFTR expression and maturation. They also suggest that the effect of GSNO is dependent on Csp and on intracellular SNO trafficking. We speculate that these data will be of relevance to the development of NO donor-based therapies for CF.
The plasmasphere and advances in plasmaspheric research

A review is made of recent major advances in plasmaspheric research; important results have emerged from those concerning a variety of plasmasphere features. Both experiments and modeling e orts have progressed. A number of unknowns still persist, however, but research is underway toward their clari cation. These clari cations are essential for obtaining a predictive capability of the near-Earth space weather in the plasmasphere region. c © 2000 Published by Elsevier Science Ltd. All rights reserved.
Feedback Phosphorylation of an RGS Protein by MAP Kinase in Yeast*

Regulators of G protein signaling (RGS proteins) are well known to accelerate G protein GTPase activity in vitro and to promote G protein desensitization in vivo. Less is known about how RGS proteins are themselves regulated. To address this question we purified the RGS in yeast, Sst2, and used electrospray ionization mass spectrometry to identify post-translational modifications. This analysis revealed that Sst2 is phosphorylated at Ser-539 and that phosphorylation occurs in response to pheromone stimulation. Ser-539 lies within a consensus mitogen-activated protein (MAP) kinase phosphorylation site, Pro-X-Ser-Pro. Phosphorylation is blocked by mutations in the MAP kinase genes (FUS3, KSS1), as well as by mutations in components needed for MAP kinase activation (STE11, STE7, STE4, STE18). Phosphorylation is also blocked by replacing Ser-539 with Ala, Asp, or Glu (but not Thr). These point mutations do not alter pheromone sensitivity, as determined by growth arrest and reporter transcription assays. However, phosphorylation appears to slow the rate of Sst2 degradation. These findings indicate that the G protein-regulated MAP kinase in yeast can act as a feedback regulator of Sst2, itself a regulator of G protein signaling.