Miracle-dz/UniFAR-FTUs huggingface dataset:
DNA Damage and Oxidative Stress in Patients with Osteoarthritis: a Pilot Study

Objective: We aimed to investigate the effect of osteoarthritis on basal levels of DNA strand breaks and on the oxidative/anti-oxidative status of patients with osteoarthritis, and healthy subjects. Patients and Methods: The study population contained 29 patients with knee osteoarthritis and 26 healthy controls. We used single-cell gel electrophoresis (also called comet assay) to measure DNA strand breaks in peripheral blood mononuclear leukocytes. Plasma levels of total antioxidant status (TAS) and total oxidative status (TOS) were determined, and oxidative stress index OSI was calculated using a novel automated measurement method. Results: The mean values of DNA damage, plasma TOS and OSI were significantly higher in patients with osteoarthritis than in controls (p < 0.001, for all). Plasma TAS level was lower in patients than in healthy controls (p < 0.001). There was a significantly positive correlation between OSI and DNA damage (r = 0.530, p < 0.001). Conclusion: The findings indicated that Reactive Oxygen Species produced in the progression of the disease may induce oxidative damage in normal cells. (Rheumatism 2007; 60-3)
VATS Thymectomy for Nonthymomatous Myasthenia Gravis Standardized Outcome Assessment Using the Myasthenia Gravis Foundation of America Clinical Classification

Objective Video-assisted thoracoscopic (VATS) thymectomy has been practiced in Australia for nearly two decades. Our aim was to assess the complete stable remission and asymptomatic disease rates after VATS thymectomy in nonthymomatous myasthenia gravis. There remains doubt that minimally invasive techniques achieve equal remission rates to open maximal operations. Therefore, we report our outcomes using the Myasthenia Gravis Foundation of America (MGFA) Clinical Classification and Kaplan-Meier analysis and compare the results to the literature. Methods A retrospective analysis of 78 consecutive patients undergoing right VATS thymectomy between April 1994 and March 2007 at two Thoracic Surgery Units in Melbourne, Australia, was undertaken. Patients with thymoma were excluded. Therefore, 57 patients were followed-up for a minimum of 12 months to apply the MGFA Clinical Classification. VATS thymectomy was performed by a three-port right side technique. Results The complete stable remission rate was 15% at 3 years and 28% at 5 years. The asymptomatic disease rate was 59% at 5 years. Median follow-up was 32 months. No prognostic factors for remission were identified. The overall morbidity rate was 14% (8/57). Conclusions Right VATS thymectomy achieves comparable remission and asymptomatic disease rates to other minimally invasive and open techniques when compared with studies using either MGFA or older criteria.
trans-(2,2′-Bipyrimidine)diiodido(isopropoxido)oxidorhenium(V)

In the title compound, [Re(C3H7O)I2O(C8H6N4)], the ReV atom adopts a distorted octahedral ReI2O2N2 geometry, with the O atoms in a trans conformation and the I atoms in a cis conformation. Two intramolecular C—H⋯I contacts occur. The crystal structure is stabilized by intermolecular C—H⋯O, C—H⋯N and C—H⋯I hydrogen bonds.
DAMPAK TEKNOLOGI INFORMASI DAN SUMBER DAYA MANUSIA TERHADAP PENERAPAN E-GOVERNMENT SEBAGAI BENTUK PELAYANAN PUBLIK

ABSTRACT This study aims to determine the Influence of Information Technology and Human Resources on the Application of E-Government as a Public Service (Case study on PT Bank Mandiri Micro Business Cluster Asembagus). This study uses primary data that is the spread of questionnaires on Bank Mandiri employees who numbered 32 Respondents and then from the results of these answers will be managed further to find out the results of these studies. The research method used is multiple linear regression analysis. The results of this study can be seen that the variable of information technology has a positive and significant impact on the implementation of e-government. the higher the level of technology used by employees of Bank Mandiri, the better the implementation of e-government in Bank Mandiri in providing public services to the public. And variable of human resource have positive and significant influence to e-government application. the higher the quality of human resources, the better the application of e-government in the institution. Keywords : information technology, human resources, e-government. Correspondence to : diyahprobowulan@unmuhjember.ac. id ABSTRAK Penelitian ini bertujuan untuk mengetahui Pengaruh Teknologi Informasi dan Sumber Daya Manusia terhadap Penerapan E-Government sebagai Bentuk Pelayanan Publik (Study kasus pada PT Bank Mandiri Micro Business Cluster Asembagus). Penelitian ini menggunakan data primer yaitu penyebaran kuesioner pada karyawan Bank Mandiri yang berjumlaah 32 Responden dan kemudian dari hasil jawaban tersebut akan dikelola lebih lanjut untuk mengetahui hasil penelitian tersebut. Metode penelitian yang digunakan adalah analisis regresi linier berganda.Hasil penelitian ini dapat diketahui bahwa variabel teknologi informasi berpengaruh positif dan signifikan terhadap penerapan e-government. semakin tinggi tingkat teknologi yang digunakan oleh karyawan Bank Mandiri maka semakin baik penerapan e-government dalam Bank mandiri dalam memberikan pelayanan publik kepada masyarakat luas. Dan variabel sumber daya manusia berpengaruh positif dan signifikan terhadap penerapan e-government. semakin tinggi kualitas sumber daya manusia yang dimiliki maka semakin baik penerapan e-government di lembaga tersebut. Kata kunci : teknologi informasi, sumber daya manusia, e-government. Korespondensi : diyahprobowulan@unmuhjember.ac. id
Stress induced defects and transistor leakage for shallow trench isolated SOI

Anomalous leakage currents are observed for shallow trench isolated SOI transistors. The leakage effect is caused by stress induced dislocations in the device silicon islands. These dislocations are observed using cross-sectional TEM analysis. For the shallow trench isolation process employed, the leakage is most pronounced on SIMOX wafers when the buried oxide thickness is scaled down to 100 nm. Limiting fabrication stresses to a minimum is critical for eliminating this leakage defect and in obtaining a robust, high yielding SOI STI process.
The Effect of Entrepreneurial Behavior on Salted Fish Business Performance at Muara Angke

Business performance was one of the benchmarks of entrepreneurial behavior so the concept of entrepreneurial behavior in businessmen is important, because it will impact on business performance. Entrepreneurial behavior is formed by two factors namely individual and environmental factors. The objective of this research were to analyze the effect of individual and environmental factors that influence entrepreneurial behavior and to analyze the influence of entrepreneurial behavior on business performance of Salted fish in Muara Angke. This research used Structural Equation Modeling-Partial Least Square (SEM-PLS) 3.0 for quantitative analysis. The result of this research indicated that individual factor had a positive effect and it was significant on entrepreneurial behavior with coefficient value 0.317 and t-statistics 3.860, while the environmental factor in salted fish business had a positive effect, and it was insignificant on entrepreneurial behavior because the value of t-statistics was 1,262 1.96, which means that any increase of entrepreneurial behavior will improve business performance of salted fish businessmen in Muara Angke. Keywords: entrepreneurial behavior, business performance, salted fish, partial least square
Impact of Dietary Habits and Physical Activity on Bone Health among 40 to 60 Year Old Females at Risk of Osteoporosis in India

Osteoporosis is a disorder of bones with increasing risk among women. However, a number of modifiable factors can help in combating this disorder. Present study examined the relationship of diet and physical activity and risk of osteoporosis through biochemical tests, bone mass density (BMD) scores, and standard questionnaires. Genetic risk for osteoporosis, presence of osteoarthritis, and thyroid problems were found among 8%, 7%, and 3% of participants, respectively; and 78% had onset of menopause between 47 to 55 years of age. Results revealed that less intake of proteins, minerals, and diverse fruit and vegetable consumption was significantly (p ≤ 0.05; 0.01) correlated with decreased BMD score and serum calcium. It was concluded that adequate intake of varied fruits and vegetables, good protein, habit of daily physical activity, adequate sun exposure, and dietary calcium, may play a promising role in decreasing the risk of osteoporosis among women of this age group.
The PDGFRβ–AKT Pathway Contributes to CDDP-Acquired Resistance in Testicular Germ Cell Tumors

Purpose: We examined whether PI3K–AKT or extracellular signal–regulated kinase (ERK) signaling pathways could play a role in the development of cisplatin (CDDP) resistance in testicular germ cell tumor (TGT) cells. Experimental Design: We compared AKT and ERK activation levels in CDDP-sensitive testicular tumor cells and in their corresponding CDDP-resistant–derived cells. We also analyzed these pathways in orthotopic testicular tumors and human patient samples. Results: Our results indicated that there was overactivation of AKT in CDDP-resistant cells compared with sensitive cells, but no effect on activated ERK levels. We observed an increase in mRNA and protein levels for platelet-derived growth factor (PDGF) receptor β and PDGF-B ligand. These were responsible for AKT overactivation in CDDP-resistant cells. When PDGFRβ levels were decreased by short hairpin RNA (shRNA) treatment or its activation was blocked by pazopanib, CDDP-resistant cells behaved like sensitive cells. Moreover, CDDP-resistant cells were more sensitive to incubation with PDGFRβ inhibitors such as pazopanib or sunitinib than sensitive cells, a finding consistent with these cells being dependent on this signaling pathway. We also found overexpression of PDGFRβ and pAKT in CDDP-resistant choriocarcinoma orthotopic tumor versus their CDDP-sensitive counterparts. Finally, we found high PDGFRβ levels in human testicular tumors, and overexpression in CDDP-resistant testicular choriocarcinomas compared with the CDDP-sensitive and nontreated tumors. Conclusions: The PDGFRβ–AKT pathway plays a critical role in the development of CDDP resistance in testicular tumoral cells. Clin Cancer Res; 20(3); 658–67. ©2013 AACR.
Share Repurchases and Stock Option Grants

This paper shows evidence for the hypothesis that the CEO opportunistically times share repurchases around her grants of at-the-money stock options. We find that firms decrease their repurchase activity in the quarter before the stock option grant to the CEO. When the option grant constitutes a larger fraction of the CEO's salary, firms more strongly change their repurchase activity. An alternative hypothesis is that CEOs time stock option grants rather than share repurchases. This hypothesis gives rise to the expectation that the effect is mostly present in unscheduled options. However, we find that the effect is present for both scheduled and unscheduled grants which is not consistent with this alternative hypothesis.
Improving quality of teaching is part of improving retention: A study of first year students in an Australian university.

This study validates Tinto's theory of student departure in a population of continuing first year university students attending an Australian university. Academic and social integration were strongly related to institutional goal commitment in these students who persisted with their university studies. Good Teaching (as measured by the CEQ) showed strong correlations with academic and social integration and satisfaction. Academic and social integration and satisfaction, all contributed to intentions to remain in study. This study indicates that improving the quality of teaching should be one element of approaches to improving first year student retention. The relationships between these dimensions of the student experience warrant further attention, particularly in cross institutional studies and in relation to those who leave study.
Weights of Children with Major Congenital Abnormalities of the Intestinal Tract

It is widely held amongst paediatric surgeons that babies born with major congenital abnormalities remain srnall even after successful surgical treatment. Forshall (1960) showed that many children with certain deformities achieve normal weight after correction; but no systematic study of the pattern of their long-term development appears to have been carried out. The purpose of this investigation was to review the weight gain of 160 children whose congenital abnormalities had been successfully treated by operation in the neonatal period. The conditions selected for review were: oesophageal atresia and tracheo-oesophageal fistula, duodenal atresia, jejunal and ileal atresia, ano-rectal agenesis and exomphalos. The weight of many children was recorded at regular follow-up visits or on readmission for aftertreatment or for some other illness; in the remainder the mothers were asked to weigh the children
Assessment of health-promoting lifestyle behaviors of adults living in the semi-rural area

OBJECTIVE: The aim of the present study was to determine the level of healthy lifestyle behaviors and related factors in the individuals who applied to the primary health-care center. METHODS: The study is a cross-sectional study of adults aged 18 years and over who applied to the primary health-care center. The sample size of the study was calculated as 992 people and 995 participants were accessible. The health-promoting behaviors of the individuals were assessed by the Health-Promoting Lifestyle Profile II (HPLP-II). In the analysis of the data, Mann–Whitney U-test, Kruskal–Wallis tests, and multiple linear regression analysis were used to determine effective variables on scale score. RESULTS: The mean age of the participants was 43.8±17.1. Of the total participants, 45.7% (n=455) of them were female. The median score obtained from the HPLP-II was 132. Health responsibility, nutrition, and interpersonal relations subscale scores of male were lower than female patients, while physical activity subscale scores were higher in male patients. In participants under the age of 48 years in the study, health responsibility, nutrition, interpersonal relations, and stress management subscale scores were higher. The scores of the married participants were higher than the areas out of the stress management subdimension. Stress management subscale scores were higher in individuals with primary and lower education levels in terms of health care, nutrition, and interpersonal relations. Those who had good family income status and health perception scores also received higher scores in terms of all subscale scores. CONCLUSION: Gender, age group, marital status, education level, income level, physician-diagnosed chronic disease history, and perceived health status were found to be related to health-promoting behaviors. Educational programs should be prepared in these issues by determining the issues that individuals are lacking in protecting and developing their health and social needs should be taken into consideration when these programs are being prepared.
A New Model-Free Method for MIMO Systems and Discussion on Model-Free or Model-Based

Current model-free adaptive control (MFAC) can hardly deal with the time delay problem in multiple-input multiple-output (MIMO) systems. To solve this problem, a novel model-free adaptive predictive control (MFAPC) method is proposed. Compared to the current MFAC, i) the proposed method is based on a kind of prediction model which derives from the equivalent-dynamic-linearization model (EDLM) modified with stochastic disturbance; ii) the previous assumptions and applicable range of MFAPC are extended wider. The leading coefficient of the control input vector in system description is no more restricted in the diagonally dominant square matrix; iii) the performance analysis and the issue of how to choose the matrix {\lambda} are completed by an easy manner that is analyzing the function of the closed-loop poles, while both problems may not be realized by the previous contraction mapping method.
Chain-loaded variable resistance warm-up improves free-weight maximal back squat performance

Abstract The acute influence of chain-loaded variable resistance exercise on subsequent free-weight one-repetition maximum (1-RM) back squat performance was examined in 16 recreationally active men. The participants performed either a free-weight resistance (FWR) or chain-loaded resistance (CLR) back squat warm-up at 85% 1-RM on two separate occasions. After a 5-min rest, the participants attempted a free-weight 1-RM back squat; if successful, subsequent 5% load additions were made until participants failed to complete the lift. During the 1-RM trials, 3D knee joint kinematics and knee extensor and flexor electromyograms (EMG) were recorded simultaneously. Significantly greater 1-RM (6.2 ± 5.0%; p < .01) and mean eccentric knee extensor EMG (32.2 ± 6.7%; p < .01) were found after the CLR warm-up compared to the FWR condition. However, no difference (p > .05) was found in concentric EMG, eccentric or concentric knee angular velocity, or peak knee flexion angle. Performing a CLR warm-up enhanced subsequent free-weight 1-RM performance without changes in knee flexion angle or eccentric and concentric knee angular velocities; thus a real 1-RM increase was achieved as the mechanics of the lift were not altered. These results are indicative of a potentiating effect of CLR in a warm-up, which may benefit athletes in tasks where high-level strength is required.
Primary and second primary cancer in 649 patients with malignancies of the maxillofacial region.

AIM The aim of this study was to analyse the outcome of patients with oral and maxillofacial (OMF) cancer. The emphasis was to evaluate the outcome of patients with second primary cancer. PATIENTS AND METHODS A total of 649 patients were retrospectively evaluated (male: 457; female: 192). All patients were treated for a primary cancer at the department of OMF surgery, Eppendorf University Hospital, Germany. All patients were reclassified (UICC TNM-system, 1992). The follow-ups were analysed separately for primary and second primary cancer. RESULTS Seventy-seven of 649 patients developed a second cancer (11.9%; male: 50; female: 27). Second primaries were synchronous (18.2%) or metachronous (76.6%; necropsy: 5.2%). The index tumor was located in the OMF region in 49 patients (63.6%). The incidence of second cancer inside the OMF region was 49 cases (7.5% of all patients). The mean survival differed significantly between patients with one cancer and those with two (127 months vs. 48 months p < 0.001). However, these differences were not significant when survivals were calculated with diagnosis of the index tumor as the reference time-point. About a third of second primaries in the OMF region succeeded a primary of other organs. CONCLUSION Patients who develop second cancer are younger than single OMF cancer patients at the time-point they acquire their index tumor. Successful therapy for a primary cancer that had developed inside or outside the OMF region expands the life-span of cancer patients. These patients are at risk of developing second primaries. Inspection of the upper aerodigestive tract should be included in the follow-up of cancer patients who survive cancer that originated in other organs. Tumor markers are needed to define this subgroup of cancer patients.
Evaluation of a prevention programme efficiency for patients with fixed orthodontic appliances.

BACKGROUND/AIM Orthodontic treatment enables the establishment of functional occlusion and improvement of oral health, however, it increases the risk of periodontal disease development. The aim of this paper was to examine the efficiency of the applied programme for the prevention of gingivitis in children undergoing the fixed orthodontic appliance therapy and to determine the most efficient devices and techniques for maintaining oral hygiene during orthodontic treatment. METHODS The study included 80 patients of both genders--60 patients comprised the experimental group and 20 patients comprised the control group. All of them were patients of the Clinic for Orthodontics at the School of Dentistry in Belgrade, aged between 13 and 18. The Silness-Löe Plaque Index (PI) was utilised for the assessment of oral hygiene quality and Silness-Löe Gingival Index (GI) and Mühlemann Papilla Bleeding Index (PBI) were utilised for the assessment of gingival state. Checkups were conducted as a single-blind study at the beginning and after the first, the third and the sixth month of the preventive and prophylactic programme. RESULTS During the observed period, a statistically significant change in PI, GI and PBI values was noticed (p < 0.005), as well as the difference in the dynamics of value changes during the periods between the observed groups. CONCLUSION The preventive programme, applied to children undergoing the fixed orthodontic appliance therapy, had a positive effect both on oral hygiene quality and gingival state. The values of the examined parameters of the patients from the experimental group were significantly lower in comparison with those of the patients from the control group. The most efficient combination of devices for oral hygiene during orthodontic treatment was: a Curaprox CP5460 toothbrush, CD Ortho 60 orthodontic toothbrush and Curaprox CPS 14 interdental brush.
Validation of an immunoassay for anti-Müllerian hormone measurements and reference intervals in healthy Brazilian subjects

Background Anti-Müllerian hormone is marker of ovarian and testicular reserve. The clinical use of this hormone requires proper standardization of reference intervals. The aims of this study were to validate the Anti-Müllerian hormone Gen II immunoassay, to establish Anti-Müllerian hormone reference intervals in healthy subjects, and to evaluate the influence of hormonal contraceptives, smoking, and body mass index on Anti-Müllerian hormone. Methods The validation of the Anti-Müllerian hormone Gen II assay (Beckman Coulter Company, TX, USA) was performed using a simplified protocol recommended by Clinical Laboratory Standard Institute. One-hundred and thirty-three healthy females and 120 males were prospectively selected for this study. Results The analytical and functional sensitivities of the Anti-Müllerian hormone Gen II immunoassay were 0.02 and 0.2 ng/mL, respectively. Intra-assay coefficients ranged from 5.2 to 9.0%, whereas inter-assay precision ranged from 4.6 to 7.8% at different concentrations. In females, Anti-Müllerian hormone showed progressive decline with increasing age (r = −0.4, p < 0.001), whereas in males, age showed no influence on Anti-Müllerian hormone concentrations. In females, Anti-Müllerian hormone concentrations did not differ between users and non-users of hormonal contraceptives, smokers, and non-smokers and obese and lean individuals. However, there was a negative and significant correlation between Anti-Müllerian hormone and body mass index in males (r = −0.3, p = 0.008). Conclusions Anti-Müllerian hormone Gen II assay was reliable for determining serum Anti-Müllerian hormone concentrations. Anti-Müllerian hormone concentrations declined with aging and presented a wide inter-individual variability. The lack of influence of hormonal contraceptives, smoking, and obesity on Anti-Müllerian hormone in both sexes allowed us to refine the normative concentrations for the Brazilian population.