Miracle-dz/UniFAR-FTUs huggingface dataset:
Cognitive reserve and preinjury educational attainment: effects on outcome of community-based rehabilitation for longer-term individuals with acquired brain injury

The cognitive reserve hypothesis has been proposed to account for the mismatch between brain pathology and its clinical expression. The aim of the current research was to explore, in a longitudinal data set, the effects of level of educational attainment before brain injury (cognitive reserve) and clinical factors on the level of rehabilitation-induced changes in disability and community integration. Participants in receipt of postacute rehabilitation were assessed at induction to the service and again at between 14 and 18 months of follow-up while still in service on changes in aspects of their abilities, adjustment and participation (Mayo Portland Adaptability Indices) and community integration (Community Integration Questionnaire). Controlling for type and severity of injury, age at onset of injury and duration of time since injury, participants with higher previous educational attainment showed significantly greater changes over the course of rehabilitation on adjustment to their injury and participation, but not on abilities, or community integration following postacute rehabilitation. Level of education would appear to be an important element of cognitive reserve in brain injury that serves to aid responses to postacute rehabilitation in terms of an individual’s adjustment to disability and participation.
Combining Search, Social Media, and Traditional Data Sources to Improve Influenza Surveillance

We present a machine learning-based methodology capable of providing real-time (“nowcast”) and forecast estimates of influenza activity in the US by leveraging data from multiple data sources including: Google searches, Twitter microblogs, nearly real-time hospital visit records, and data from a participatory surveillance system. Our main contribution consists of combining multiple influenza-like illnesses (ILI) activity estimates, generated independently with each data source, into a single prediction of ILI utilizing machine learning ensemble approaches. Our methodology exploits the information in each data source and produces accurate weekly ILI predictions for up to four weeks ahead of the release of CDC’s ILI reports. We evaluate the predictive ability of our ensemble approach during the 2013–2014 (retrospective) and 2014–2015 (live) flu seasons for each of the four weekly time horizons. Our ensemble approach demonstrates several advantages: (1) our ensemble method’s predictions outperform every prediction using each data source independently, (2) our methodology can produce predictions one week ahead of GFT’s real-time estimates with comparable accuracy, and (3) our two and three week forecast estimates have comparable accuracy to real-time predictions using an autoregressive model. Moreover, our results show that considerable insight is gained from incorporating disparate data streams, in the form of social media and crowd sourced data, into influenza predictions in all time horizons.
The Vaccinia Virus-Encoded Bcl-2 Homologues Do Not Act as Direct Bax Inhibitors

ABSTRACT Many viruses, including members of several poxvirus genera, encode inhibitors that block apoptosis by simultaneously binding the proapoptotic Bcl-2 proteins Bak and Bax. The Orthopoxvirus vaccinia virus encodes the Bcl-2-like F1 protein, which sequesters Bak but not Bax. However, N1, a potent virulence factor, is reported to be antiapoptotic and to interact with Bax. Here we investigated whether vaccinia virus inhibits Bak/Bax-dependent apoptosis via the cooperative action of F1 and N1. We found that Western Reserve (WR) and ΔN1L viruses inhibited drug- and infection-induced apoptosis equally. Meanwhile, infections with ΔF1L or ΔN1L/F1L virus resulted in similar levels of Bax activation and apoptosis. Outside the context of infection, N1 did not block drug- or Bax-induced cell death or interact with Bax. In addition to F1 and N1, vaccinia virus encodes further structural homologs of Bcl-2 proteins that are conserved in orthopoxviruses, including A46, A52, B14, C1, C6, C16/B22, K7, and N2. However, we found that these do not associate with Bax or inhibit drug-induced cell death. Based on our findings that N1 is not an antiapoptotic protein, we propose that the F1 orthologs represent the only orthopoxvirus Bcl-2 homolog to directly inhibit the Bak/Bax checkpoint.
Frequency of brain injury in a forensic psychiatric population.

OBJECTIVE Over the last years, a growing number of studies involving individual patients and/or populations have demonstrated that Traumatic Brain Injuries (TBI) determine innumerable psychiatric symptoms, including significant alterations which may influence diagnoses, prognosis and treatment, not to mention clear psychosocial implications (both legal and those related to social security). The objectives of this study were 1) to detect the existence of TBI in a forensic psychiatric population before the occurrence of the wrongs; 2) To verify whether or not those injuries had been identified by the experts at the psychiatric institution. METHOD 3,323 records of patients examined by forensic experts at the Forensic Psychiatric Institute Dr. Maurício Cardoso in Porto Alegre were analyzed; the records covered the period between 1995 and 1999. RESULTS in the studied population, there were 133 cases of TBI prior to the wrongs, 39 of which were mild, and 94, moderate or severe. Out of the total number of TBI cases found, 111 cases were not taken into account, many of them having motoric, cognitive, psychic and sensori perception alterations. CONCLUSION the significant number of patients that had had TBI before having committed a wrong - a fact that had not been considered by the experts (neurologists and psychiatrists) at the institution - is a strong indicator of how little attention is paid to the consequences of these injuries. Considering the relevance of the psychosocial aspects, new studies should be conducted in psychiatric populations to increase the knowledge about the consequences of these injuries.
How Close Have Universal Health Systems Come to Achieving Equity in Use of Curative Services? A Systematic Review

Most governments in established market economies have developed universal systems of health care, but these are being increasingly threatened by widespread health sector reforms. Hence, it is more important than ever to monitor the effects of policy changes on the ability of universal systems to achieve their equity goals. This article provides evidence for such monitoring. The authors present the results of a systematic review of equity in use of curative health services in universal systems, together with a critical appraisal of the essential components of studies to address this question. Of the 79 studies identified that addressed the review question, only 26 met the inclusion criteria and adjusted for differential health need across socioeconomic groups. The authors found a pro-rich bias in use of specialist hospital services and a reasonably equitable access to primary health care by different socioeconomic groups. There was a wide inter-study variation in the difference in utilization rates between people of high and low socioeconomic groups. Improvements are needed in the way that equity in universal systems is monitored, with particular attention to how “need” is defined and to the impact on patients of indirect costs.
MORPHOLOGICAL STUDIES OF THE SPLEEN IN IDIOPATHIC PORTAL HYPERTENSION (SO‐CALLED BANTI'S SYNDROME WITHOUT LIVER CIRRHOSIS) USING LIGHT MICROSCOPY, SCANNING ELECTRON MICROSCOPY AND HISTOMETRY

Morphological changes in the spleens of patients with idiopathic portal hypertension (IPH) were studied and compared with the normal spleen. The study used (1) light microscopy with histometry, (2) scanning electron microscopy (SEM) of the splenic tissue with histometry and (3) SEM of the spleen vascular replica. Histometrical studies by light microscopy showed that the volume of red pulp of IPH was increased in a unit area and to a total of 12 times the normal in the whole spleen. The white pulp was scanty of lymphocytes and decreased in a unit area but it was increased in the whole spleen. SEM of the white pulp of IPH demonstrated many channels formed by reticulum cells and running parallel with each other along the central artery. This finding presumably corresponds to periarterial fibrosis in light microscopy. SEM histometry demonstrated that the venous sinuses of IPH were small but increased in number and occupied the same percentage area in a unit red pulp area as in the normal spleen. The Billroth cord of IPH was narrowed and occupied by thickened reticulum cells, which may cause increased pooling and destruction of blood cells in the enlarged spleen (hypersplenism). SEM of the tissue and vascular replica demonstrated open arterial termination in the Billroth cord in the spleen of IPH as well as in the normal spleen. Venous sinuses in the replica of IPH ran parallel with each other forming bundles with fewer intercommunications than normal.
Immunity to rubella among women of child‐bearing age

Summary. The results of testing for rubella antibodies in over 6000 sera from women of child‐bearing age are reported and analysed according to pregnant state, age, country of origin and social class. There was no difference between the rubella seroprevalence rates in women who were pregnant and in those who were contemplating pregnancy in the future. Likewise, women (either pregnant or non‐pregnant) who were young enough to have been offered rubella vaccine at school were not more likely to be immune to rubella than were older women. Rubella seropositivity rates were not influenced by social class but significantly higher rates were found in women born in European or Arabian than in African or Asian countries. We conclude that the national scheme for rubella immunization has not reduced the number of women susceptible to rubella entering pregnancy in this Health District and that greater attention should be paid to immunization of women of child‐bearing age from African or Asian countries.
Hormone profiles and reproductive characteristics in wild female Japanese macaques (Macaca fuscata)

In this study we investigated the reproductive characteristics of wild female Japanese macaques (Macaca fuscata fuscata) in 2 nonconsecutive years using noninvasive methods to monitor physiological events. We detected ovulation dates and ascertained conceptions from fecal hormone profiles. First ovulations occurred from middle October to early November in 1997, and from middle to late November in 1999. Most females conceived during their first ovarian cycle. On average, postconception bleeding occurred 18.4 days after ovulation, and menstruation occurred 13.7 days after ovulation. The average gestation length was 176.3 days. The average degree of facial redness and the percentage of females that copulated synchronously changed across the ovarian cycle and peaked in the periovulatory period. Although prolonged periods of postconception copulation have been reported in previous studies, they did not occur in this study, which suggests that such behavior may not be a species‐typical characteristic. Female fertility varied between the 2 years. The copulation rates of females with no infant <1 year of age were 100% (14/14) in 1997 and 45.5% (5/11) in 1999. The ovulation rates of the female subjects that we chose for hormonal assays were 100% (9/9) in 1997 and 50.0% (3/6) in 1999. Th conception rates of these selected females were 100% (9/9) in 1997 and 16.7% (1/6) in 1999. The birth rates (the number of females that delivered divided by the total number of adult females in the troop) were 73.3% (11/15) in 1998 and 6.7% (1/15) in 2000. The modified birth rates (the number of females that delivered /the number of adult females with no infant <1 year of age) × 100 were 78.6% (11/14) in 1998 and 9.1% (1/11) in 2000. Am. J. Primatol. 64:367–375, 2004. © 2004 Wiley‐Liss, Inc.
Inhibition of R-plasmid transfer in Escherichia coli by 4-quinolones

Inhibition of transfer of four conjugative R plasmids by ciprofloxacin, enoxacin, norfloxacin, ofloxacin, and pipemidic acid was investigated in an Escherichia coli mating system. The absolute concentrations needed for inhibition of conjugation varied from 0.12 microgram/ml for ciprofloxacin to 16 micrograms/ml for pipemidic acid, but the relationship to the MICs for the parent strains was identical for all substrates. Concentrations for a 90% reduction of transconjugants were in the range of one to six times the MIC for the parent strains, which also had lethal effects on donors and recipients. A similar effect on conjugation was found with chloramphenicol. These observations question the specificity of transfer inhibition by quinolones and cast doubt on the clinical importance of such an effect.
Modeling the detectability of vesicoureteral reflux using microwave radiometry

We present the modeling efforts on antenna design, frequency selection and receiver sensitivity estimation to detect vesicoureteral reflux (VUR) using microwave (MW) radiometry as warm urine from the bladder maintained at fever range temperature using a MW hyperthermia device reflows into the kidneys. The radiometer center frequency (fc), frequency band (Δf) and aperture radius (ra) of the physical antenna for kidney temperature monitoring are determined using a simplified universal antenna model with a circular aperture. Anatomical information extracted from the computed tomography (CT) images of children aged 4–6 years is used to construct a layered 3D tissue model. Radiometric antenna efficiency is evaluated in terms of the ratio of the power collected from the target at depth to the total power received by the antenna (η). The power ratio of the theoretical antenna is used to design a microstrip log spiral antenna with directional radiation pattern over fc ± Δf/2. Power received by the log spiral from the deep target is enhanced using a thin low-loss dielectric matching layer. A cylindrical metal cup is proposed to shield the antenna from electromagnetic interference (EMI). Transient thermal simulations are carried out to determine the minimum detectable change in the antenna brightness temperature (δTB) for 15–25 mL urine refluxes at 40–42 °C located 35 mm from the skin surface. Theoretical antenna simulations indicate maximum η over 1.1–1.6 GHz for ra = 30–40 mm. Simulations of the 35 mm radius tapered log spiral yielded a higher power ratio over fc ± Δf/2 for the 35–40 mm deep targets in the presence of an optimal matching layer. Radiometric temperature calculations indicate δTB ⩾ 0.1 K for the 15 mL urine at 40 °C and 35 mm depth. Higher η and δTB were observed for the antenna and matching layer inside the metal cup. Reflection measurements of the log spiral in a saline phantom are in agreement with the simulation data. The numerical study suggests that a radiometer with fc = 1.35 GHz, Δf = 500 MHz and detector sensitivity better than 0.1 K would be the appropriate tool to noninvasively detect VUR using the log spiral antenna.
Activation of the σE-Dependent Stress Pathway by Conjugative TraR May Anticipate Conjugational Stress

ABSTRACT Horizontal gene transfer by conjugation plays a major role in bacterial evolution, allowing the acquisition of new traits, such as virulence and resistance to antibacterial agents. With the increased antibiotic resistance in bacterial pathogens, a better understanding of how bacteria modulate conjugation under changing environments and the genetic factors involved is needed. Despite the evolutionary advantages conjugation may confer, the process can be quite stressful for the donor cell. Here, we characterize the ability of TraR, encoded on the episomal F′ plasmid, to upregulate the σE extracytoplasmic stress pathway in Escherichia coli. TraR, a DksA homolog, modulates transcription initiation through the secondary channel of RNA polymerase. We show here that TraR activates transcription directly; however, unlike DksA, it does so without using ppGpp as a cofactor. TraR expression can stimulate the σE extracytoplasmic stress response independently of the DegS/RseA signal transduction cascade. In the absence of TraR, bacteria carrying conjugative plasmids become more susceptible to external stress. We propose that TraR increases the concentrations of periplasmic chaperones and proteases by directly activating the transcription of σE-dependent promoters; this increased protein folding capacity may prepare the bacterium to endure the periplasmic stress of sex pilus biosynthesis during mating.
Perceived Barriers to Interning Abroad: Perceptions from African American Social Work Students

This qualitative study was conducted at a small historically Black college and university (HBCU) in the southern region of the United States. It explored the perceived barriers to interning abroad for social work students. Twenty (n = 20) full-time students were recruited and data was collected using individual in-depth interviews. Findings from this study shed light on information that might lead to a deeper understanding of some barriers to interning abroad at an HBCU.
Is there a benefit to early angiography in patients with ST-segment depression myocardial infarction? An observational study.

BACKGROUND AND OBJECTIVE Patients with ST-segment depression myocardial infarction (MI) have a similar long-term outcome compared with those who have ST-segment elevation. It remains unclear whether an aggressive treatment approach with very early (<6 hours) angiography and revascularization improves outcome over an early conservative approach. We compared the short-term outcome of patients who received very early (<6 hours) angiography with patients who received early conservative therapy for ST-segment depression MI. METHODS Patients seen within 12 hours with ST-segment depression on the initial electrocardiogram (ECG) were identified from the National Registry of Myocardial Infarction 2 (NRMI) database, which collected information from 1994 to 1998. Those who received very early (<6 hours) angiography were compared with those who received early conservative therapy. The short-term outcomes, including major bleeding episodes, cerebral vascular events, recurrent ischemia and angina, MI, and death, were compared on the basis of the initial therapy received. RESULTS Patients treated with very early angiography (2402) were younger, more likely to be males, smokers, and have less of a cardiac history (angina, MI, congestive heart failure, aortocoronary bypass surgery) and less likely to have diabetes mellitus than those who received early conservative therapy (17,735). Hospital outcome in the very early angiography group was similar to the early conservative therapy group in terms of cerebral vascular events (0.8% vs 1.0%, P =.27), major bleeding events (2.8% vs 2.4%, P =.25), and recurrent MI (2.1% vs 2.3%, P =.57) but was associated with lower recurrent ischemia or angina (11.4% vs 16.7%, P <.001) and improved survival (death, 4.9% vs 7.3%, P <.001). Multivariate analysis suggested that patients receiving very early angiography had lower mortality compared with those receiving early conservative therapy (odds ratio [OR] = 0.76; 95% CI 0.60-0.95). However, comparing patients matched on propensity score (1405) showed mortality was similar in both treatment groups (5.6% vs 5.4%, P =.87), with no significant inhospital mortality benefit of very early angiography (OR = 0.89; 95% CI 0.71-1.13). CONCLUSIONS The apparent mortality benefit of very early angiography in patients with ST-segment depression MI is a reflection of bias by confounding. Controlling for baseline differences using propensity score methods in this observational study indicated no inhospital mortality benefit of a very early aggressive approach compared with a conservative approach.
The Effects of Off‐Farm Work on Fertilizer and Pesticide Expenditures in China

This study examines the effects of participation in off-farm work on farm expenditures on fertilizer and pesticide, using farm household survey data from China. Simple mean value comparisons reveal no statistically significant differences in fertilizer and pesticide expenditures between off-farm work participants and nonparticipants. However, econometric estimation with a treatment effects model shows a negative selection bias. After controlling for this bias, the empirical results show that participation in off-farm work exerts a positive and statistically significant impact on fertilizer and pesticide expenditures. Our findings generally suggest that the income effect of off-farm work stimulates agricultural production by increasing investments in productivity-enhancing inputs.
Within-Plant Distribution of Bemisia tabaci (Homoptera: Aleyrodidae) Adults and Immatures on Greenhouse-Grown Winter Cucumber Plants

Abstract Within-plant distribution of adults, pupae, nymphs, and eggs of Bemisia tabaci (Gennadius) (Homoptera: Aleyrodidae) on leaves of greenhouse-grown winter cucumber, Cucumis sativum L. , plants were studied in field plots for integrated pest management decision making. Distribution of specific life stages depended on the leaf positions. The leaves with most abundance and low or lowest variation of whiteflies were leaves 8–12 for adults, 8–11 for pupae, 6–12 for nymphs, and 6–9 for eggs. In light of the criterion in selecting within-plant sample sites with pest abundance and low variation, these leaves were considered as the most convenient for sampling specific life stages of B. tabaci. Single a and b values for each life stage of the whitefly were calculated by Taylor’s power law and were used to estimate minimum sample sizes at a precision of 0.25 (SE/mean). The minimum sample size decreased with increasing density of adults on leaves 8–12, of nymphs on leaves 7 and 8, and of eggs on leaf 6, but slightly increased with increasing density of pupae on leaves 8–11, of nymphs on leaves 6 and 9–12, and of eggs on leaves 7–9.
The Right Turn in India: Authoritarianism, Populism and Neoliberalisation

ABSTRACT This article argues that the growth of authoritarian forms of politics in India should be seen in the context of a long-term crisis of the state as successive governments have been unable to establish legitimacy for the policies of neoliberalisation that have been pursued since the 1990s. These policies contributed to the fracturing of dominant modes of political incorporation. The previous Congress Party-led government’s mode of crisis management – which it dubbed, inclusive growth – failed to create new forms of political incorporation by addressing long-term structural problems in India’s political economy, such as jobless growth, and gave rise to new problems, such as large-scale corruption scandals. Subsequently, it increasingly developed what Nicos Poulantzas called, “authoritarian statist” tendencies to marginalise dissent within a framework of constitutional democracy. The current Bharatiya Janata Party-led government’s mode of crisis management builds on these authoritarian statist tendencies but has sought to build legitimacy for these tendencies and neoliberalisation through an appeal to authoritarian populism. This seeks to harness popular discontent against elite corruption with majoritarianism to create an antagonism between the “Hindu people” and a “corrupt elite” that panders to minorities.