Miracle-dz/UniFAR-FTUs huggingface dataset:
Intraoperative radiation for limb sparing of the distal aspect of the radius without transcarpal plating in five dogs.

OBJECTIVES To evaluate intraoperative irradiation (IORT) as a method of limb spare with preservation of the radiocarpal joint. STUDY DESIGN Prospective case series. ANIMALS Dogs (n=5) with stage II sarcoma of the distal aspect of the radius. METHODS A bone segment containing the tumor was isolated surgically, treated by IORT, reimplanted, and secured by internal fixation. In 1 dog, the postradiation tumor bed was curetted and filled with bone cement. Dogs were administered alternating adriamycin and carboplatin starting 2 weeks after IORT and monitored at regular intervals. RESULTS Four dogs had osteosarcoma and 1 had undifferentiated sarcoma. Implant failure (n=3), deep tissue infection (3), and pathologic fracture (3) resulted in amputation (3) or pancarpal plating (2). The dog with undifferentiated sarcoma was euthanatized because of suspected tumor recurrence 4 months postoperatively. Osteotomy healing was documented by radiography (1), histopathology (2), or by direct observation (2). CONCLUSIONS A technique for limb-sparing surgery of the distal portion of the radius in dogs using IORT had advantages include healing of the autograft and a source for a perfectly fitting autograft but did not appear to offer any advantage with respect to infection rate. Long-term preservation of the radiocarpal joint was not successful. CLINICAL RELEVANCE It was not possible to preserve the function of the radiocarpal joint and so this technique cannot be recommended currently. Further study is needed to evaluate whether or not IORT can be considered in combination with pancarpal plating and possibly curettage and cementation of the tumor to prevent subchondral bone collapse.
Double contrast barium enema sensitivity: a comparison of studies by radiographers and radiologists.

PURPOSE A retrospective study of histologically proven cases of colorectal cancer (CRC) was performed to assess whether the sensitivity of the radiographer-performed double contrast barium enema (DCBE) differed from that of the radiologist-performed study. MATERIALS AND METHODS Histologically proven cases of CRC were reviewed over a 3-year period to ascertain whether: the diagnosis had been made by DCBE in the 3 years before histological diagnosis; the lesion had been correctly diagnosed; the examination had been performed by a radiologist or radiographer. RESULTS In the 3-year period there were 478 cases with histologically proven CRC. Of these, 239 (50%) had undergone DCBE as the initial radiological investigation of the colon. Sixty-four examinations had been performed by radiographers. A correct diagnosis was made in 58 cases (90.6%), the report was equivocal in one case (1.6%), there were four false-negatives (6.25%), and one case was abandoned (1.6%). One hundred and seventy-five examinations were performed by radiologists. A correct diagnosis was made in 157 cases (89.7%), the report was equivocal in one case (0.6%), there were 16 false-negatives (9.1%), and one case was abandoned (0.6%). CONCLUSION A sensitivity of 90.6% for radiographer-performed studies compared favourably with 89.7% for radiologist-performed studies and supports the practice of radiographers undertaking barium enemas.
ESG integration: value, growth and momentum

This study provides finer-grained results on the financial effectiveness of ESG integration for mainstream active investment styles. We account for firm size, industry and country effects within ESG scores and introduce the concept of ESG risk materiality. Empirical evidence shows that US and European investors can raise their portfolio’s ESG level and increase risk-adjusted performance at the same time. Therefore, we add to the growing demand for sustainable products in the traditional investment industry and overcome the notion of ESG integration being a burden to traditional investment strategies.
Perniosis in Association With Anorexia Nervosa

Abstract: Several dermatologic abnormalities have been described In anorexia nervosa, but only rare associations have been made with pernlosis. We recently saw two teenage girls and one woman with anorexia nervosa who had symptoms of perniosis. We suggest that altered ther moregulation and a hyperreactive peripheral vascular response to cold in anorexia nervosa may predispose these patients to permiosis.
Multimodal therapy of word retrieval disorder due to phonological encoding dysfunction

Objective: To determine whether phonological multimodal therapy can improve naming and communication in a patient showing a lexical phonological naming disorder. This study employed oral and written learning tasks, using an error reduction procedure. Methods: A single-case design computer-assisted treatment was used with a 52 year-old woman with fluent aphasia consecutive to a cerebral infarction. The cognitive analysis of her word retrieval disorder exhibited a phonological encoding dysfunction. Thus, a phonological procedure was designed addressing the output phonological lexicon using computer analysis of spoken and written words. The effects were tested for trained words, generalization to untrained words, maintenance and specificity. Transfer of improvement to daily life was also assessed. Outcomes and results: After therapy, the verbal naming of both trained and untrained words was improved at p < 0.001. The improvement was still maintained after 3 months without therapy. This treatment was specific since the word dictation task did not change. Communication in daily life was improved at p < 0.05. Conclusions: This study of a patient with word retrieval disorder due to phonological encoding dysfunction demonstrated the effectiveness of a phonological and multimodal therapeutic treatment.
The Hip Functional Retrieval after Elective Surgery May Be Enhanced by Supplemented Essential Amino Acids

It is not known whether postsurgery systemic inflammation and plasma amino acid abnormalities are still present during rehabilitation of individuals after elective hip arthroplasty (EHA). Sixty subjects (36 females; age 66.58 ± 8.37 years) were randomized to receive 14-day oral EAAs (8 g/day) or a placebo (maltodextrin). At admission to and discharge from the rehabilitation center, serum C-reactive protein (CRP) and venous plasma amino acid concentrations were determined. Post-EHA hip function was evaluated by Harris hip score (HHS) test. Ten matched healthy subjects served as controls. At baseline, all patients had high CRP levels, considerable reduction in several amino acids, and severely reduced hip function (HHS 40.78 ± 2.70 scores). After treatment, inflammation decreased both in the EAA group and in the placebo group. Only EAA patients significantly improved their levels of glycine, alanine, tyrosine, and total amino acids. In addition, they enhanced the rate of hip function recovery (HHS) (from baseline 41.8 ± 1.15 to 76.37 ± 6.6 versus baseline 39.78 ± 4.89 to 70.0 ± 7.1 in placebo one; p = 0.006). The study documents the persistence of inflammation and plasma amino acid abnormalities in post-EHA rehabilitation phase. EAAs enhance hip function retrieval and improve plasma amino acid abnormalities.
Utilization of oral health care services among adults attending community outreach programs.

INTRODUCTION Good oral health is a mirror of overall health and well-being. Oral health is determined by diet, oral hygiene practices, and the pattern of dental visits. Poor oral health has significant social and economic consequences. Outreach programs conducted by dental schools offer an opportunity for early diagnosis and treatment, dental health education, and institution of preventive measures. OBJECTIVE To assess the utilization of oral healthcare services among adults attending outreach programs. MATERIALS AND METHODS This study included 246 adults aged 18-55 years attending community outreach programs in and around Bangalore. Using a questionnaire we collected data on dental visits, perceived oral health status, reasons for seeking care, and barriers in seeking care. Statistical significance was assessed using the Chi-square test. RESULTS In this sample, 28% had visited the dentist in the last 12 months. Males visited dentist more frequently than females. The main reason for a dental visit was for tooth extraction (11%), followed by restorative and endodontic treatment 6%. The main barriers to utilization of dental services were high cost (22%), inability to take time off from child care duties (19.5%), and fear of the dentist or dental tools (8.5%). CONCLUSION The utilization of dental services in this population was poor. The majority of the dental visits were for treatment of acute symptoms rather than for preventive care. High cost was the main barrier to the utilization of dental services. Policies and programs should focus on these factors to decrease the burden of oral diseases and to improve quality of life among the socioeconomically disadvantaged.
Liberalizing markets, liberalizing welfare? Economic reform and social regulation in the EU's electricity regime

ABSTRACT This article argues that the European Union (EU) is promoting a liberal model of welfare through social regulation. Focusing on the liberalization and regulation of the electricity sector, the article asks how and for what reasons social protection of vulnerable consumers was introduced into this sector, and what kind of welfare policy this represents. This article shows that social measures grew substantially between the second and third directives on electricity sector liberalization (2005–2009), advanced by the European Parliament and reluctantly adopted by the Commission. This development runs counter to our understanding of electricity sector reform as focused primarily on liberalization, competition and efficiency. It is argued that the introduction of social protection advanced the process of economic reform, even when the measures introduced were in themselves inefficient. This social regulation, however, not only reflects a liberal, targeted and minimal understanding of welfare, but also pushes social policy in member states in this same direction.
Phase composition of lipoprotein SM/cholesterol/PtdCho affects FA specificity of sPLA2s This work was supported in part by grants-in-aid from the Heart and Stroke Foundation of Ontario, Canada. Published, JLR Papers in Press, June 27, 2008.

We have previously reported preferential release of polyunsaturated FAs during hydrolysis of lipoprotein phosphatidylcholine (PtdCho) by group X secretory phospholipase A2 (sPLA2) and preferential release of oligounsaturated FAs during hydrolysis of lipoprotein PtdCho by group V sPLA2, but the mechanism of this selectivity has remained unknown. We now show that the rate and specificity of hydrolysis are affected by relative increases in endogenous SM and free cholesterol (FC) during the lipase digestion. The highest preference for arachidonate release from LDL and HDL by group X sPLA2 was observed for residual SM/PtdCho molar ratio of 1.2 and 0.4, compared with the respective starting ratios of 0.4 and 0.2, as measured by liquid chromatography/electrospray ionization-mass spectrometry. Group V sPLA2 showed preferential release of linoleate from LDL and HDL at SM/PtdCho ratio 1.5 and 0.6, respectively. We have attributed the change in FA specificity to segregation of molecular species of PtdCho and of sPLA2s between disordered and ordered SM/FC/PtdCho lipid phases. The increases in SM and FC during digestion with group IIA sPLA2 were more limited, and a preferential hydrolysis of any FAs was not observed. The significance of SM and FC SM and FC accumulation during sPLA2 hydrolysis of lipoprotein PtdCho has been previously overlooked.
Design and Performance Analysis of Nonlinearity Preprocessors in an Impulsive Noise Environment

This paper discusses a practical design of nonlinearity preprocessors to be used in a receiver for mitigating performance degradation in an impulsive noise environment. A simple method is proposed for a blanker and a soft limiter to calculate a blanking and a clipping threshold, respectively. In addition, to evaluate the bit error performance of a receiver with the proposed nonlinearity preprocessors, this paper introduces an approach using a periodic pulse train function and Fourier series. When a nonlinearity preprocessor is used, since the output samples show a truncated probability density function, it is generally difficult to evaluate the bit error performance of a receiver. Analytical and simulation results show that the thresholds computed by the proposed method are near optimal in terms of efficacy function and that the error performance of the proposed nonlinearity preprocessors matches well with that of the ideal design of nonlinearity preprocessors with optimal thresholds.
Murine Immune Response to a Chronic Staphylococcus aureus Biofilm Infection

ABSTRACT Staphylococcus aureus has reemerged as an important human pathogen in recent decades. Although many infections caused by this microbial species persist through a biofilm mode of growth, little is known about how the host's adaptive immune system responds to these biofilm infections. In this study, S. aureus cells adhered to pins in culture and were subsequently inserted into the tibiae of C57BL/6 mice, with an infecting dose of 2 × 105 CFU. This model was utilized to determine local cytokine levels, antibody (Ab) function, and T cell populations at multiple time points throughout infection. Like human hosts, S. aureus implant infection was chronic and remained localized in 100% of C57BL/6 mice at a consistent level of approximately 107 CFU/gram bone tissue after day 7. This infection persisted locally for >49 days and was recalcitrant to clearance by the host immune response and antimicrobial therapy. Local inflammatory cytokines of the Th1 (interleukin-2 [IL-2], IL-12 p70, tumor necrosis factor alpha [TNF-α], and IL-1β) and Th17 (IL-6 and IL-17) responses were upregulated throughout the infection, except IL-12 p70, which dwindled late in the infection. In addition, Th1 Ab subtypes against a biofilm antigen (SA0486) were upregulated early in the infection, while Th2 Abs and anti-inflammatory regulatory T cells (Tregs) were not upregulated until later. These results indicate that early Th1 and Th17 inflammatory responses and downregulated Th2 and Treg responses occur during the development of a chronic biofilm implant infection. This unrestrained inflammatory response may cause tissue damage, thereby enabling S. aureus to attach and thrive in a biofilm mode of growth.
Performance of the classification criteria in patients with late-onset axial spondyloarthritis

Abstract Aim: To evaluate the performance of four different classification criteria for spondyloarthritis (SpA) in patients with late-onset symptoms and to compare the clinical, laboratory and radiographic outcomes among the patients with symptoms before and after 45 years of age. Patients and methods: A total of 329 patients with SpA were enrolled in this prospective cohort. Patients with psoriatic arthritis, reactive arthritis, colitis associated arthritis and peripheral or undifferentiated SpA were excluded. The remaining individuals were divided into two groups based on their ages at the time of onset of symptoms: from 16 to 45 years of age (adult-onset, A-O) and after 45 years of age (late-onset, L-O). The clinical data were collected, including BASDAI, BASFI, BASMI, mSASSS, ASDAS, as were concomitant diseases and medications, efficacy and safety data. The performance of four SpA classification criteria, including modified New York, ESSG, Amor and ASAS, was evaluated in both groups. p value <. 05 was considered as significant. Results: Thirty-two patients (9.72%) had L-O axial SpA. Mean age of diagnosis and symptoms were 57.6 (8.0) years and 7.6 (5.1) years, respectively. L-O patients had statistically worse functional impairment and higher disease activity. However, they had lower radiographic sacroiliac and spine damage (p < .001). Conclusion: Our data showed that almost 10% of the patients with SpA had late-onset of symptoms. Moreover, they had higher disease activity, worse physical function and lower spine radiographic damage than A-O SpA patients. Additionally, the ASAS classification criteria had the best performance and might be used in clinical practice.
Cloning and sequence of cymA, a gene encoding a tetraheme cytochrome c required for reduction of iron(III), fumarate, and nitrate by Shewanella putrefaciens MR-1

The cymA gene, which encodes a tetraheme cytochrome c, was cloned from Shewanella putrefaciens MR-1. This gene complemented a mutant which had a TnphoA insertion in cymA and which was deficient in the respiratory reduction of iron(III), nitrate, fumarate, and manganese(IV). The 561-bp nucleotide sequence of cymA encodes a protein of 187 amino acids with a predicted molecular mass of 20.8 kDa. No N-terminal signal sequence was readily apparent; consistent with this, a cytochrome with a size of 21 kDa was detected in the wild type but was absent in the insertional mutant. The cymA gene is transcribed into an mRNA; the major transcript was approximately 790 bases, suggesting that it is not part of a multicistronic operon. This RNA transcript was not detected in the cymA mutant. The CymA protein was found in the cytoplasmic membrane and soluble fraction of MR-1, and it shares partial amino acid sequence homology with multiheme c-type cytochromes from other bacteria. These cytochromes are ostensibly involved in the transfer of electrons from the cytoplasmic membrane to acceptors in the periplasm. The localization of the fumarate and iron(III) reductases to the periplasm and outer membrane of MR-1, respectively, suggests the possibility of a similar electron transfer role for CymA.
Service Lifetime, Storage Time, and Disposal Pathways of Electronic Equipment: A Swiss Case Study

Product lifetime is an essential aspect of dynamic material flow analyses and has been modeled using lifetime distribution functions, mostly average lifetimes. Existing data regarding the lifetime of electronic equipment (EE) are based on diverging definitions of lifetime as well as different temporal and regional scopes. After its active use, EE is often not disposed of immediately, but remains in storage for some time. Specific data on the share of EE that is stored and the time they remain in storage are scarce. This article investigates the service lifetime, storage time, and disposal pathways of ten electronic device types, based on data from an online survey complemented by structured interviews. We distinguish between new and secondhand devices and compute histograms, averages, and medians of the different lifetimes and their change over time. The average service lifetime varies from 3.3 years for mobile phones to 10.8 years for large loudspeakers, the average storage time from 0.8 years for flat panel display televisions to 3.6 years for large loudspeakers. Most service lifetime histograms are positively skewed and show substantial differences among device types. The storage time histograms, being more similar to one another, indicate that the storage behavior is similar for most device types. The data on disposal pathways show that a large proportion of devices are stored and reused before they reach the collection scheme.
Environmental noise reduction configuration: Effects on preferences, satisfaction, and speech understanding

Abstract The effects of four configurations of an environmental noise reduction (ENR) algorithm on preferences, speech understanding, and satisfaction were investigated. The gain reduction at 0 dB modulation depth was either 10 dB in all channels (ENR StrongFlat) or shaped from 2–10 dB across channels according to a speech importance function (ENR MildSII). This gain reduction was either invariant (ENR Constant) or varied with (ENR Variable) the noise level. Ten hearing-impaired participants blindly compared pairs of configurations in real-world situations and recorded their preferences. Sentence reception thresholds (SRTs) were measured in quiet and noise, and satisfaction was rated with speech in noise. Half of the participants preferred ENR MildSII and half preferred ENR StrongFlat. All preferred ENR Variable to ENR Constant. Overall, the preferred ENR configuration was preferred to ENR off in 90% of responses. No statistically significant effect on SRTs was found, but a clinically significant effect of up to 2 dB could not be ruled out from the available data. ENR significantly improved satisfaction for listening comfort, ease of speech understanding, and sound quality. Sumario Se investigaron los efectos de cuatro configuraciones de un algoritmo de reduction del ruido ambiental (ENR) sobre preferencias, comprensión del lenguaje y satisfactión. La reductión de la ganancia con 0 dB de profundidad de modulatión fue tanto de 10 dB en todos los canales (ENR StrongFlat) como conformada de 2–10 dB en todos los canales de acuerdo con la funcion de importancia del lenguaje (ENR MildSII). Esta reduccion de ganancia fue tanto invariable (ENR constante) como variable (ENR variable) con el nivel del ruido. Diez participantes hipoacusicos compararon a ciegas pares de configuraciones, en situaciones reales, y registraron sus preferencias. Los umbrales de reception de oraciones (SRTs) se midieron con y sin ruido y se calificó la satisfactión con lenguaje en ruido. La mitad de los participantes prefirieron ENR MildSII y la mitad pre-firieron ENR StrogFlat. Todos prefirieron la ENR variable frente a la ENR constante. Globalmente, la configuratión preferida de ENR fue la de ENRoff en el 90% de las respuestas. No se encontró un efecto estadistico significativo en los SRTs, y no puede estable-cerse un efecto clinicamente significativo por encima de 2 dB, con los datos disponibles. El ENR mejoró significativamente la satisfaction en cuanto a la comodidad para oir, la facilidad para la comprensión del lenguaje y la calidad del sonido.
Characterization of Tn3000, a Transposon Responsible for blaNDM-1 Dissemination among Enterobacteriaceae in Brazil, Nepal, Morocco, and India

ABSTRACT In Enterobacteriaceae, the blaNDM genes have been found in many different genetic contexts, and a wide diversity of plasmid scaffolds bearing those genes has been found. In August 2013, we identified NDM-1-producing Escherichia coli and Enterobacter hormaechei strains from a single rectal swab sample from a patient hospitalized in Rio de Janeiro, Brazil, who had no history of travel abroad. Complete DNA sequencing using the Illumina platform and annotation of the two plasmids harboring the blaNDM-1 gene, one from each strain, showed that they belonged to incompatibility groups IncFIIK and IncX3 and harbored a novel transposon named Tn3000. Similar genetic structures have been identified among other isolates in Brazil but also on plasmids from other continents. Our findings suggest that the blaNDM-1 gene may be transmitted by Tn3000 in different parts of the world.