Miracle-dz/UniFAR-FTUs huggingface dataset:
Asymmetric Dimethylarginine Levels and Enhances Angiogenesis Overexpression of Dimethylarginine Dimethylaminohydrolase Reduces Tissue

Copyright © 2005 American Heart Association. All rights reserved. Print ISSN: 0009-7322. Online 72514 Circulation is published by the American Heart Association. 7272 Greenville Avenue, Dallas, TX DOI: 10.1161/01.CIR. 0000158487.80483. 09 2005;111;1431-1438 Circulation John P. Cooke Dayoub, Bingyin Wang, Andrew J. Patterson, Masumi Kimoto, Helen M. Blau and Johannes Jacobi, Karsten Sydow, Georges von Degenfeld, Ying Zhang, Hayan Asymmetric Dimethylarginine Levels and Enhances Angiogenesis Overexpression of Dimethylarginine Dimethylaminohydrolase Reduces Tissue http://circ.ahajournals. org/cgi/content/full/111/11/1431 located on the World Wide Web at: The online version of this article, along with updated information and services, is
Studies on fatty acid oxidation. VI. The effects of fatty acids on the metabolism of Ehrlich ascites carcinoma cells.

Summary 1.Octanoic and higher fatty acids inhibited the respiration of tumor slices. The inhibitory effect of glucose on respiration was not apparent in the presence of fatty acids. 2.The general effect of these fatty acids on Ehrlich ascites carcinoma cells was similar to that of dinitrophenol (DNP). In the presence of glucose, both decanoate and DNP finally abolished the respiratory activity of ascites cells. 3.The effects of decanoate were probably consequences of its capacity to uncouple oxidation from phosphorylation which, in turn, leads to a stimulation of lactic acid production by aerobic glycolysis and a sharp fall in pH. This fall in pH may be delayed in the presence of extra phosphate buffer. This accounts for the erroneous conclusion that phosphate reverses the Crabtree Effect. 4.The effects of octanol and guanidine, which also stimulate aerobic glycolysis, were considered.
Essential Oil Compositions of Three Lantana Species from Monteverde, Costa Rica

The leaf essential oils of three species of Lantana from Monteverde, Costa Rica (L. camara, L. velutina, and L. hirta) were obtained by hydrodistillation and the chemical compositions determined by GC-MS analysis. The principal components of L. velutina were limonene (21.4%), (E)-caryophyllene (23.4%) and bicyclogermacrene (8.2%). The leaf oil composition of L. hirta was relatively simple, containing mostly 1-octen-3-ol (64.6%), germacrene D (24.5%), and (E)-caryophyllene (10.9%). Two different samples of L. camara, however, yielded vastly different leaf oil compositions; one was dominated by sesquiterpenes, (E)-caryophyllene (30.3%), γ-muurolene (27.2%), bicyclogermacrene (24.4%) and β-elemene (14.2%); the second sample, on the other hand, was composed largely of fatty acid-derivatives, (Z)-3-hexenol and 1-octen-3-ol. The very different compositions for L. camara are consistent with the wide diversity of chemical compositions observed in previous reports for this species.
Effects of somatostatin on lipid metabolism of larvae and metamorphosing landlocked sea lamprey, Petromyzon marinus.

This study was designed to examine the role of somatostatin in regulating changes in lipid metabolism of larvae and metamorphosing landlocked sea lamprey, Petromyzon marinus. Larvae and animals in late metamorphosis (stage 6 on a 7-stage scale) were injected intraperitoneally once per day for 2 days with either saline (0.6%) or somatostatin-14 (SS-14; 500 ng/g body wt). Injection of SS-14 into larval and stage 6 metamorphosing animals resulted in elevated plasma fatty acids levels. In larvae, SS-14-induced hyperlipidemia was supported by enhanced lipolysis, as indicated by increased triacylglycerol lipase (TGL) activity in the liver and kidney. Mobilization of larval renal lipid was accompanied by reduced TG synthesis, as indicated by decreased diacylglycerol acyltransferase (DGAT) activity. In stage 6 metamorphosing lamprey, SS-14 did not significantly affect TGL activity; however, SS-14 significantly reduced fatty acid synthesis, as measured by acetyl-CoA carboxylase activity, in kidney, liver, and muscle, as well as muscular TG synthesis. SS-14-stimulated lipid depletion is reminiscent of the pattern of lipid metabolism displayed by P. marinus during their spontaneous metamorphosis-an observation which suggests that somatostatin may play a role in metamorphosis-associated changes in lipid metabolism in this species.
Nursing students’ perceptions of patient dignity

Background: Respecting patients’ dignity has been described as a fundamental part of nursing care. Many studies have focused on exploring the concept of patients’ dignity from the patient and nurse perspective, but knowledge is limited regarding students’ nursing perceptions and experiences. Objective: To explore the issue of patients’ dignity from the perspective of nursing students. Research design: A qualitative study was employed with the formation of four focus groups and the participation of nursing students. Data were analysed via a thematic content analysis of the discussions. Participants and research context: Thirty-four nursing students of a Cyprus University participated in the four focus groups. Each group was homogenous in terms of the year of study and heterogeneous in terms of clinical practice in various wards. Ethical consideration: The study’s protocol was reviewed and approved by the Cyprus National Bioethics Committee. Ethical standards were followed throughout the study. Findings: Several factors that maintain or compromise patients’ dignity emerged. These factors were grouped into five themes: (a) patients’ preferences, verbal abuse and regarding a patient as a unique person; (b) privacy and confidentiality; (c) loss of autonomy and need for help; (d) discrimination and (e) attribution and reciprocity. Discussion: Different understandings of the perceived concept of dignity and the factors that maintain or compromise patient’s dignity were expressed through the eyes and the feelings of nursing students. Students highlighted the importance of promoting patient dignity as an important component of nursing care. Conclusion: Nurse educators can use the findings of this study in order to tailor nursing programmes to emphasise the importance of respecting patients’ dignity. In addition, nurse ward managers can use the findings as means for persuading nurses to change current behaviour.
Dual Stochastic Dominance and Related Mean-Risk Models

We consider the problem of constructing mean-risk models which are consistent with the second degree stochastic dominance relation. By exploiting duality relations of convex analysis we develop the quantile model of stochastic dominance for general distributions. This allows us to show that several models using quantiles and tail characteristics of the distribution are in harmony with the stochastic dominance relation. We also provide stochastic linear programming formulations of these models.
Immunophenotypic profiles of peripheral blood lymphocytes on the day of embryo transfer in women undergoing in vitro fertilization.

UNLABELLED Evaluation of different types of lymphocyte subpopulations in the peripheral blood has unknown and controversial significance in diagnosis of infertility. The aim of the study was to evaluate selected blood lymphocytes in patients treated with intracytoplasmic sperm injection (ICSI). MATERIALS AND METHODS women were divided into three groups: (1) control fertile group (n=18), (2) infertile women that achieved (n=32), and (3) did not achieve a pregnancy after ICSI (n=26). The following types of leukocytes were analyzed by three-colour flow cytometry by detection of specific CD antigens: lymphocytes T (CD3+), B (CD19+ and CD5+CD19+), T and B (CD5+), NK cells (CD56+CD16-, CD56-CD16+, CD56+CD16+, CD56brightCD16-, CD56dimCD16+). Additionally, the antigen of early activation (CD69) was evaluated on T, B and NK cells. The results were presented as a percentage and total counts of all lymphocytes. RESULTS The percentage of total NK cells (CD56+CD16+, CD56+CD16- and CD56-CD16+) did not differ between pregnant and non pregnant women and was lower comparing to control group. Fractions of CD56-CD16+ cells were higher in pregnant vs. non-pregnant women. The percentages of CD56brightCD16- NK cells were higher in control group comparing to both ICSI treated groups. Other fractions of lymphocyte subpopulations, including activated cells (with CD69 expression) did not differ between the analyzed groups. Total counts of CD56-CD16+ cells were higher in pregnant vs. non-pregnant group, and the CD56brightCD16- cells was more abundant in control group vs. women with unsuccessful ICSI. CONCLUSIONS Testing of peripheral blood NK cells and the others lymphocytes has limited value as a prognostic factor in ICSI treated patients. The antigen of early lymphocytic activation (CD69) has not any predictive value in prognosis of ICSI outcome.
Prostanoid receptor antagonists: development strategies and therapeutic applications

Identification of the primary products of cyclo‐oxygenase (COX)/prostaglandin synthase(s), which occurred between 1958 and 1976, was followed by a classification system for prostanoid receptors (DP, EP1, EP2 …) based mainly on the pharmacological actions of natural and synthetic agonists and a few antagonists. The design of potent selective antagonists was rapid for certain prostanoid receptors (EP1, TP), slow for others (FP, IP) and has yet to be achieved in certain cases (EP2). While some antagonists are structurally related to the natural agonist, most recent compounds are ‘non‐prostanoid’ (often acyl‐sulphonamides) and have emerged from high‐throughput screening of compound libraries, made possible by the development of (functional) assays involving single recombinant prostanoid receptors. Selective antagonists have been crucial to defining the roles of PGD2 (acting on DP1 and DP2 receptors) and PGE2 (on EP1 and EP4 receptors) in various inflammatory conditions; there are clear opportunities for therapeutic intervention. The vast endeavour on TP (thromboxane) antagonists is considered in relation to their limited pharmaceutical success in the cardiovascular area. Correspondingly, the clinical utility of IP (prostacyclin) antagonists is assessed in relation to the cloud hanging over the long‐term safety of selective COX‐2 inhibitors. Aspirin apart, COX inhibitors broadly suppress all prostanoid pathways, while high selectivity has been a major goal in receptor antagonist development; more targeted therapy may require an intermediate position with defined antagonist selectivity profiles. This review is intended to provide overviews of each antagonist class (including prostamide antagonists), covering major development strategies and current and potential clinical usage.
Ultrasound measurement of biparietal diameter and umbilical artery blood flow in the normal fetal guinea pig.

BACKGROUND AND PURPOSE Measurement of the biparietal diameter (BPD) by use of B-mode ultrasound provides a useful means for assessment of gestational age and brain growth in humans during pregnancy. Recording of flow velocity waveforms from the umbilical artery, using Doppler ultrasound, is used to assess development of the fetal placental circulation. We sought to measure these ultrasound parameters during normal pregnancy in the guinea pig and develop normative data. METHODS Measurements of BPD were made on 205 fetuses of various gestational ages; 114 fetuses had 2 or more serial studies performed (total n = 474). RESULTS BPD increased from 0.806cm at 22 to 26 days, to 1.922cm at term (69 days), (y = -0.00043x2 + 0.06881x - 0.75941, with an r value of 0.995, where x = days' gestation, y = biparietal diameter [cm]). Umbilical artery flow velocity waveform resistance index (RI) decreased as gestation advanced (y = -0.012x + 1.294 with an r value of 0.887, where x = days gestation, y = RI) reflecting expansion of the placental vascular bed. CONCLUSIONS It is possible to use ultrasound to study pregnancy in the guinea pig. The BPD may be used to estimate gestational age. Resistance to blood flow in the placenta may be assessed using the RI derived from the umbilical artery flow velocity waveform.
Uncoupled IP3 receptor can function as a Ca2+‐leak channel: cell biological and pathological consequences

Ca2+ release via intracellular release channels, IP3Rs (inositol 1,4,5‐trisphosphate receptors) and RyRs (ryanodine receptors), is perhaps the most ubiquitous and versatile cellular signalling mechanism, and is involved in a vast number of cellular processes. In addition to this classical release pathway there is limited, but yet persistent, information about less well‐defined Ca2+‐leak pathways that may play an important role in the control of the Ca2+ load of the endo(sarco)plasmic reticulum. The mechanisms responsible for this ‘basal’ leak are not known, but recent data suggest that both IP3Rs and RyRs may also operate as Ca2+‐leak channels, particularly in pathological conditions. Proteolytic cleavage or biochemical modification (such as hyperphosphorylation or nitrosylation), for example, occurring during conditions of cell stress or apoptosis, can functionally uncouple the cytoplasmic control domains from the channel domain of the receptor. Highly significant information has been obtained from studies of malfunctioning channels in various disorders; for example, RyRs in cardiac malfunction or genetic muscle diseases and IP3Rs in neurodegenerative diseases. In this review we aim to summarize the existing information about functionally uncoupled IP3R and RyR channels, and to discuss the concept that those channels can participate in Ca2+‐leak pathways.
Defective Regulation and Action of Atrial Natriuretic Peptide in Type 2 Diabetes

Increased plasma atrial natriuretic peptide (ANP) levels and impaired ANP action have been reported in patients with diabetes or insulin resistance. The aim of this study was to assess the interaction between insulin and ANP in type 2 diabetes. In 12 normotensive, normoalbuminuric type 2 diabetics, we infused insulin at a high (6.6 pmol/min/kg) or, on a different day, at a low rate (0.6 pmol/min/kg) during 4 hours of isoglycemia under isovolumic, isoosmolar conditions. The normal response was established in 12 healthy volunteers using an identical protocol. Despite higher baseline ANP levels (17.7 +/- 2.8 vs. 10.8 +/- 1.8 pg/ml, p = 0.04), urinary sodium excretion was similar in diabetics and controls (113 +/- 8.5 vs. 102 +/- 8.8 mEq/24 hours, p = ns). In both groups, hyperinsulinemia caused a decrease in blood volume (0.33 +/- 0.10 l, p < 0.01), diastolic blood pressure (6 %, p < 0.02), and natriuresis. However, plasma ANP decreased in controls (from 12.7 +/- 1.9 to 8.6 +/- 1.4 pg/ml, p = 0.01) but not in type 2 diabetics (15.1 +/- 2.7 vs. 17.2 +/- 3.8 pg/ml, p = ns). We conclude that ANP release is resistant to volume stimulation in type 2 diabetic patients, and natriuresis is resistant to ANP action. This dual disruption of ANP control may play a role in blood pressure regulation in diabetes.
Enhancement of post-ischemic myocardial function by chronic 17 beta -estradiol treatment: role of alterations in glucose metabolism.

This study was designed to assess the effects of chronic estrogen replacement therapy on mechanical function and glucose utilization in aerobic and post-ischemic hearts. Ovariectomized female rats were either untreated or were treated subcutaneously with 17 beta -estradiol (0.25 mg 21-day slow release pellets). After 14 days, when serum concentrations of 17 beta -estradiol were 3.8+/-0.8 and 148+/-15 pg/ml, respectively, hearts were isolated and perfused in working mode with Krebs-Henseleit solution containing 1.2 m m palmitate and 11 m m[5-(3)H/U-(14)C]glucose. Hearts were perfused aerobically (60 min) and then subjected to low-flow ischemia (0.5 ml/min, 60 min) followed by reperfusion (30 min). During reperfusion, hearts from rats treated chronically with 17 beta -estradiol had an improved (two-fold) recovery of mechanical function. 17 beta -estradiol (400 p m, 109 pg/ml), when present acutely in heart perfusate during ischemia and reperfusion, did not improve recovery. Chronic 17 beta -estradiol increased glucose oxidation during reperfusion as well as during aerobic perfusion but had no effect on glycolysis. Chronic 17 beta -estradiol also altered post-ischemic glycogen metabolism and increased glycogen content and glycogen synthase activity at the end of reperfusion. As stimulation of glucose oxidation has been shown previously to be cardioprotective, and as the enhanced rate of glucose oxidation was not simply a consequence of enhanced recovery of mechanical function, alterations in glycogen and glucose utilization may contribute to the direct cardioprotective effects of chronic estrogen treatment.
Pedigree Analysis of Familial Primary Concomitant Horizontal Strabismus in Northern India

ABSTRACT Purpose: Familial clustering of common forms of primary strabismus like esotropia (ET) and exotropia (XT) is observed in a proportion of the strabismus cohort. The genetic components of this remain unidentified. Linkage studies have demonstrated susceptibility locus for primary strabismus at the STBMS1 locus on 7p22.1 as well as other loci on 4q28.3 and 7q31.2. Recently next generation sequencing (NGS) technology has emerged as a powerful tool in discovery genomics and a large number of novel disease-causing variants are being reported. In this study, we recruited informative families for subsequent genetic analysis for disease-causing variant identification. Methods: All consecutive families with two or more affected members with primary concomitant horizontal strabismus were prospectively recruited at the ophthalmic outpatients department (OPD) of Lady Hardinge Medical College, New Delhi, from August 2014 to February 2017. Detailed phenotypic evaluation and pedigree documentation was performed. Results: Of the 39 recruited families of north Indian origin, 18 families each had affected family members demonstrating either ET or XT. 100% concordance of the phenotype in the affected family members was observed in these families. While vertical transmission was observed in 17/18 families with XT, 7 with ET had affected members across one generation, 2 demonstrated consanguineous pedigree, and 2 comprised identical twin families. In 3 families, a combination of ET and XT was noted. This comprised one family with the ET and XT patients being from 2 separate arms of the family related by marriage, one family where one sibling had XT and the other had ET, and another family where the maternal aunt of the affected proband with ET had XT. Conclusions: Subjects with familial primary concomitant strabismus recruited in this study may provide a valuable resource to unravel the genetic determinants of this condition, which is a common disorder of early childhood with high ophthalmic morbidity.
Effects of Conditioning on Physical Fitness and Club Head Speed in Mature Golfers

The purpose of this study was to evaluate the effects of an 8-wk. conditioning program on selected measures of physical fitness and golf performance for 12 male and 5 female recreational golfers (M age = 52.4 yr., SD = 6.7 yr.). Measurements were made at baseline and following the intervention. The twice-per-week program consisted of strength training, flexibility, and plyometric exercises. Analysis of the pre- and posttest scores showed that conditioning was associated with significant increases in muscular strength, flexibility, and club head speed. Without a control group, the data suggest conditioning may be a worthwhile activity for mature golfers.
Promotion by Collagen Tripeptide of Type I Collagen Gene Expression in Human Osteoblastic Cells and Fracture Healing of Rat Femur

Peptides produced by the enzymatic degradation of collagens are reported to have various activities of biological and medical interest. The mechanisms underlying their actions are, however, poorly understood. We have produced, by collagenase digestion of type I collagen, a highly purified, non-antigenic, and low allergenic tripeptide fraction (collagen tripeptide, Ctp). We report here the effects of Ctp on the in vivo bone fracture healing and in vitro calcification of osteoblastic cells. An oral administration of Ctp to rats with a femur fracture accelerated the fracture healing. Ctp apparently stimulated the calcification of human osteoblastic cells in culture. This osteotrophic effect was accompanied by a significant increase in type I collagen protein production and its mRNA levels. DNA microarray and quantitative RT-PCR analyses demonstrated that Ctp upregulated the bone-specific transcription factor, Osterix, suggesting that the induction of type I collagen gene expression by Ctp was mediated by upregulation of this factor.
Spectra of spontaneous mutations in Escherichia coli strains defective in mismatch correction: the nature of in vivo DNA replication errors.

We have determined the DNA sequence changes in 487 spontaneous mutations in the N-terminal part of the lacI gene in mutH, mutL, and mutS strains of Escherichia coli. These strains display elevated spontaneous mutation rates because of a deficiency in the process of postreplicative mismatch correction. As a consequence the mutational spectra reveal the nature of spontaneous DNA replication errors. The spectra consist of base substitutions (75%) and single-base deletions (25%). Among the base substitutions, transitions (both A.T----G.C and G.C----A.T) are strongly favored over transversions (96% versus 4%). Large site-to-site differences are observed among identical base substitutions, presumably reflecting the modulating effects of neighboring bases. The single-base-deletion spectrum is dominated by a large hotspot at a run of adjacent identical base pairs, implying a Streisinger-slippage mechanism. The data, when compared to a previously determined wild-type spectrum, also provide information on the specificity of the mismatch repair system.
MANUSIA DAN AGAMA

Kajian tentang manusia dapat dilihat dari berbagai perspektif dan disiplin ilmu, seperti ilmu antropologi, ilmu filosofi, ilmu sosiologi, ilmu psikologi, dan ilmu al -Qur‟an. Tulisan ini mengetengahkan tentang manusia menurut pandangan Islam. Islam berpandangan bahwa manusia itu terdiri dari dua unsur, yaitu unsur materi dan non materi. Ada empat kata yang digunakan al-Qur‟an untuk menunjuk manusia, yaitu al-basyar, al-insān, al-nās, dan banī ādam. Manusia merupakan makhluk yang paling mulia dan sangat unik. Manusia dianugerahi berbagai potensi dan petunjuk kebenaran dalam menjalani kehidupan di dunia dan akhirat. Manusia memiliki potensi dasar yang dapat membedakan dengan makhluk lainnya, yaitu akal, qalbu, dan nafsu. Dalam kehidupan di dunia, selain sebagai hamba Allah, manusia juga diberi tugas men-jadi khalifah di bumi serta mengelola dan memelihara alam.
Enhancing hair follicle regeneration by nonablative fractional laser: Assessment of irradiation parameters and tissue response

Identification of methods to enhance anagen entry can be helpful for alopecia. Recently, nonablative laser has been proposed as a potential treatment for alopecia. However, how the laser parameters affect stem cell activity, hair cycles and the associated side effects have not been well characterized. Here we examine the effects of irradiation parameters of 1,550‐nm fractional laser on hair cycles.