Miracle-dz/UniFAR-FTUs huggingface dataset:
Elevated levels of von Willebrand Factor in cirrhosis support platelet adhesion despite reduced functional capacity

Cirrhosis of the liver is frequently accompanied by complex alterations in the hemostatic system, resulting in a bleeding tendency. Although many hemostatic changes in liver disease promote bleeding, compensatory mechanisms also are found, including high levels of the platelet adhesive protein von Willebrand Factor (VWF). However, conflicting reports on the functional properties of VWF in cirrhosis have appeared in literature. We have measured a panel of VWF parameters in plasma from patients with cirrhosis of varying severity and causes. Furthermore, we assessed the contribution of VWF to platelet adhesion, by measuring the ability of plasma from patients with cirrhosis to support adhesion of normal or patient platelets under flow conditions. VWF antigen levels were strongly increased in patients with cirrhosis. In contrast, the relative collagen binding activity, as well as the relative ristocetin cofactor activity, was significantly lower in patients as compared with controls, indicating loss of function. Accordingly, patients had a reduced fraction of high‐molecular‐weight VWF multimers. Both strongly elevated and reduced activity and antigen levels of the VWF cleaving protease ADAMTS13 were found in individual patients. Adhesion of either normal or patient platelets to a collagen surface was substantially increased when these platelets were resuspended in plasma of patients with cirrhosis, as compared with control plasma. In conclusion, highly elevated levels of VWF in patients with cirrhosis contribute to the induction of primary hemostasis despite reduced functional properties of the molecule. This phenomenon might compensate for defects in platelet number and function in patients with cirrhosis. (HEPATOLOGY 2006;44:53–61.)
Higher order aberrations in normal eyes measured with three different aberrometers.

PURPOSE To assess the repeatability of measurements of higher order aberrations using three different aberrometers and to compare higher order aberration measurements between optical path difference (OPD) scanning and the Hartmann-Shack method. METHODS Wavefront aberration data obtained using the NIDEK OPD-Scan, Bausch & Lomb Zywave wavefront aberrometer, and VISX CustomVue wavefront analyzer were compared. A total of 19 subjects were included in the study. The repeatability in each machine was assessed by calculating the difference between measurements and the mean of three consecutive measurements in the same eye. Subsequent analysis of the distribution of these differences yields the mean difference, the standard deviation of the differences, and the 95% confidence interval for repeated measurements, also termed the "repeatability coefficient". RESULTS Repeatability errors in all three machines were found to be low, suggesting that all three machines are reliable in their repeated measurements. Significant differences were demonstrated between OPD scanning and Hartmann-Shack aberrometers. All three machines showed statistically significant differences in several higher order aberration parameters when compared to each other. CONCLUSIONS The three different aberrometers provided repeatable measurements but statistical differences were noted in the measurement of higher order aberrations when comparing the machines. No instrument was superior over the other and all three were reliable.
Low-Absorbing and Thermally Stable Industrial Silicon Nitride Films With Very Low Surface Recombination

Amorphous silicon nitride has become the state-of-the-art antireflection coating for silicon solar cells. Optimization of silicon nitride films requires consideration of both the film's optical and electrical properties. It is commonly assumed that silicon-rich silicon nitride films (films with high refractive index) provide better surface passivation, compared to that obtained by films with lower indices. However, silicon-rich films are usually very absorptive in the short (and even medium) wavelength range. Development of low absorption silicon nitride films, that provide good surface passivation, is therefore highly valuable. In this study we compare nine different industrial silicon nitride films, all with similarly low refractive index of 2.09 ± 0.01 measured at 633 nm. We demonstrate that these films exhibit very different electrical, chemical, and optical properties despite their similar refractive index values and correlate these differences with the specific deposition conditions. As a result of this investigation, we have developed industrial thermally stable low-absorbing silicon nitride films that provide excellent surface passivation, with surface saturation current density of 7 fA/cm2 on both n- and p-type wafers. We demonstrate that the developed low absorption films provide surface passivation with equal quality to that obtained by industrial silicon-rich silicon nitride films.
Comparison of slow inactivation in human heart and rat skeletal muscle Na+ channel chimaeras

1 Voltage‐gated Na+ channels undergo two types of inactivation in response to depolarization. One type, fast inactivation, occurs with a time scale of milliseconds. The other, slow inactivation, occurs over seconds to minutes. In addition, these two processes appear to be distinct at the molecular level. However, the molecular mechanism of Na+ channel slow inactivation is unknown. 2 We used patch clamp techniques to study slow inactivation, activation and fast inactivation in α‐subunit cDNA clones for wild‐type human heart Na+ channels (hH1) and rat skeletal muscle Na+ channels (μ1) transiently expressed in human embryonic kidney (HEK) cells. Our experiments showed that the Na+ channel slow inactivation phenotype (development, steady state and recovery) differed dramatically between hH1 and μ1. Slow inactivation in μ1 had a faster onset, a steeper voltage dependence, and was more complete compared with hH1. In addition, recovery from slow inactivation was much slower for μ1 than for hH1. Activation and fast inactivation kinetics were also different in hH1 and μ1. In hH1, fast inactivation was slower and V½ values of activation and steady‐state fast inactivation (h∞) were more negative than in μ1. 3 To better understand the molecular basis of Na+ channel slow inactivation, Na+ channel chimaeras were constructed with domains from hH1 and μ1. The slow inactivation phenotype in the chimaeras (domains denoted by subscripts) μ1(1)hH1(2,3,4), μ1(1,2)hH1(3,4) and μ1(1,2,3)hH1(4) was intermediate compared with that of wild‐type. However, the chimaera μ1(1)hH1(2,3,4) was more like wild‐type hH1, while the chimaeras μ1(1,2)hH1(3,4) and μ1(1,2,3)hH1(4) were more similar to wild‐type μ1. In the chimaeras, activation resembled that of μ1, fast inactivation resembled that of hH1, and steady‐state fast inactivation fell between that of hH1 and μ1. 4 The data demonstrate that all four domains can modulate the Na+ channel slow inactivation phenotype. However, domains D1 and D2 may play a more prominent role in determining Na+ channel slow inactivation phenotype than D3 and D4. The results also support previous conclusions that D3 and D4 (and the D3–D4 linker) play an important role in Na+ channel fast inactivation, and that activation may require non‐equivalent contributions from all four domains.
Complementary currency systems and their ability to support economic and social changes

Complementary Currency Systems (CCS) are accounting systems that define local monetary spaces created by non-bank actors to pay for exchange of goods and services inside a trading network. This article aims to investigate the capability of complementary currency systems to foster social and economic changes. The authors use an analysis of the literature to examine the nature and diversity of CCS in terms of objectives, forms, modes of governance, and degrees of connection with political authorities and economic structures. They also assess the potential of CCS to support local economies based on social and environmental values, working to combat economic vulnerability and social exclusion, and examine how CCS challenge the conventional perception of money. The article ends by summarizing the challenges facing CCS, inquiring into the potential problems and benefits that a change of this sort could entail.
Short- and long-term follow-up of percutaneous coronary intervention for chronic total occlusion through transradial approach: tips for successful procedure from a single-center experience.

BACKGROUND There are limited data regarding transradial percutaneous coronary intervention (PCI) for chronic total occlusion (CTO). OBJECTIVE To assess the feasibility and safety of transradial coronary intervention (TRI) for CTO lesions, we analyzed our experience in PCI treatment of CTO lesion through transradial approach for the past 6 years. METHODS From January 2003 to May 2009, among 134 CTO lesions, on which we performed PCI, 120 lesions were performed from transradial approach. RESULTS Technical success for transradial CTO was 80%. Complication of access bleeding was zero. The most commonly selected guiding wire was Wave 3 for right coronary artery (RCA) lesions (82%) and Voda left for Left Coronary Artery (LCA) lesions (91%). The average number of wires used during procedure was 2.2 ± 0.8. Tapered wire was used in 8% of the cases, Rotablator was performed in 4.1% of cases, and Tornus catheter was performed in 12.5% of cases. The mean procedure time was 83 ± 39 minutes. The mean volume of contrast medium used was 228 ± 92 mL. There were two coronary artery perforations during procedure and one in-hospital cardiac death. Patients were followed up for 36 ± 21 months; restenosis rate was 19.5%-26.7% for bare metal stent (BMS) and 9.8% for drug-eluting stents (DES). Overall major adverse cardiac events (MACE) rate was 11.7%. CONCLUSION It was demonstrated that transradial PCI for CTO lesions is safe, minimizing vascular complications without increasing procedural time and contrast use.
Tooth loss and obesity in a defined Swedish population

Aims: To explore the association between tooth loss and obesity in an adult Swedish population, and to investigate the influence of socioeconomy, life-style, and co-morbidity. Methods: A cross-sectional population health survey conducted in 2001—2005 in 2816 randomly selected Swedish men and women (age: 30—74 years; participation rate 76%). Main measures were; tooth loss: < 20 remaining teeth (self-reported), general obesity: BMI≥30 kg m-2, abdominal obesity: waist circumference >88 in women and >102 cm in men. Adjustments were made for socioeconomy, life-style, and co-morbidity. Results: 420 individuals (21.2%) had < 20 remaining teeth: 30—59 years 6.0%, 60—74 years 53.5%. Mean BMI was similar in men and women (26.9 kg m-2), however, both general and abdominal obesity was still more frequent among women (both p < 0.001). There was a significant interaction between age and tooth loss in the association with both general (p = 0.004) and abdominal obesity (p < 0.011) in men. In participants below 60 years of age, the association between tooth loss and general obesity (OR 2.17 [95% CI 1.51 — 3.12]) and abdominal obesity (2.23 [1.58 — 3.15]), respectively, was statistically significant independent of age and gender, and remained so also when accounting for differences in socioeconomy, life-style, and co-morbidity. There was no similar association in those 60 years or older. The findings in men and women were robust and concordant. Conclusions: Common mechanisms for oral health and obesity should be explored more also including longitudinal designs. The findings are important for targeting comprehensive interventions against obesity and tooth loss, especially among younger adults.
Characterization of Trp(+) reversions in Escherichia coli strain WP2uvrA.

The Escherichia coli strain WP2uvrA is widely used in general mutagenicity screening tests because of its high sensitivity to many kinds of mutagens and it serves as a supplement to the standard Salmonella typhimurium tester strains. In contrast to Salmonella His(+) revertants, E.coli Trp(+) revertants have not been characterized at the molecular level. In this study we found that in the trpE65 allele of WP2uvrA the triplet that codes for the fourth amino acid from the N-terminus of anthranilate synthetase was an ochre stop codon (TAA) instead of a glutamine codon (CAA). In spontaneous Trp(+) revertants the ochre codon had been changed to glutamine (CAA), lysine (AAA), glutamic acid (GAA), leucine (TTA), serine (TCA) or tyrosine (TAC, TAT). Since tryptophan prototrophy could also be restored by ochre suppressor mutations at the anticodon sites in the genes for tRNA(Glu) (glnU), tRNA(Lys) (lysT) and tRNA(Tyr) (tyrT, tyrU), the Trp(+) reversion system with E.coli WP2uvrA detected five types of base substitutions, A.T-->T.A, A.T-->C.G, A.T-->G.C, G.C-->A.T and G.C-->T.A. About 30-50% of Trp(+) revertants induced by N-ethyl-N'-nitro-N-nitrosoguanidine, captan and angelicin plus UVA irradiation were attributable to reversion at the trpE65 ochre locus; the others were attributable to suppressor mutations. In contrast, almost all revertants induced by N-methyl-N'-nitro-N-nitrosoguanidine, 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone and furylfuramide were caused by suppressor mutations. Thus, the high mutagen sensitivity of WP2uvrA is due to several target sites consisting of A.T base pairs (trpE65, lysT) and G.C base pairs (glnU, tyrT, tyrU).
The Roles of Reactive Oxygen Metabolism in Drought: Not So Cut and Dried[1][C][W]

Reactive oxygen metabolism affects physiology during drought, with implications for the potential roles of antioxidant systems in restricting oxidative stress and in transmitting oxidative stress signals in these conditions. Drought is considered to cause oxidative stress, but the roles of oxidant-induced modifications in plant responses to water deficit remain obscure. Key unknowns are the roles of reactive oxygen species (ROS) produced at specific intracellular or apoplastic sites and the interactions between the complex, networking antioxidative systems in restricting ROS accumulation or in redox signal transmission. This Update discusses the physiological aspects of ROS production during drought, and analyzes the relationship between oxidative stress and drought from different but complementary perspectives. We ask to what extent redox changes are involved in plant drought responses and discuss the roles that different ROS-generating processes may play. Our discussion emphasizes the complexity and the specificity of antioxidant systems, and the likely importance of thiol systems in drought-induced redox signaling. We identify candidate drought-responsive redox-associated genes and analyze the potential importance of different metabolic pathways in drought-associated oxidative stress signaling.
Mitochondrial respiratory activity is altered in osteoarthritic human articular chondrocytes.

OBJECTIVE Osteoarthritis (OA) is a degenerative rheumatic disease that is associated with extracellular matrix degradation and chondrocyte apoptosis in the articular cartilage. The role of mitochondria in degenerative diseases is widely recognized. We undertook this study to evaluate mitochondrial function in normal and OA chondrocytes and to examine age-related changes in mitochondria. METHODS Mitochondrial function was evaluated by analyzing respiratory chain enzyme complexes and citrate synthase (CS) activities as well as changes in mitochondrial membrane potential (Delta Psi m). The activities of mitochondrial respiratory chain complexes (complex I: rotenone-sensitive NADH-coenzyme Q(1) reductase; complex II: succinate dehydrogenase; complex III: antimycin-sensitive ubiquinol cytochrome c reductase; and complex IV: cytochrome c oxidase) and CS were measured in human articular chondrocytes isolated from OA and normal cartilage. Delta Psi m was measured by JC-1 using flow cytometry. Statistical analysis was performed using the Mann-Whitney U test and Student's t-test as well as several models of multiple linear regression. RESULTS OA articular chondrocytes had reduced activities of complexes II and III compared with cells from normal cartilage. However, the mitochondrial mass was increased in OA. Cultures of OA chondrocytes contained a higher proportion of cells with de-energized mitochondria. We found no relationship between mitochondrial function and donor age either in normal or in OA chondrocytes. CONCLUSION These findings suggest the involvement of mitochondrial function in the pathophysiology of OA. Cartilage degradation by OA and cartilage aging may be two different processes.
“Conflict Management” and “Conflict Resolution” are Not Synonymous Terms

Robbins sees functional conflict as an absolute necessity within organizations and explicitly encourages it. He explains: "Survival can result only when an organization is able to adapt to constant changes in the environment. Adaption is possible only through change, and change is stimulated by conflict. " Robbins cites evidence indicating that conflict can be related to increased productivity and that critical thinking encourages well-developed decisions. He admits, however, that not all conflicts are good for the organization. Their functional or dysfunctional nature is determined by the impact of the conflict on the objectives of the organization. The author identifies several factors underlying the need for conflict stimulation: (1) managers who are surrounded by "yes men"; (2) subordinates who are afraid to admit ignorance or uncertainty; (3) decision-makers' excessive concern about hurting the feelings of others; or (4) an environment where new ideas are slow in coming forth. He suggests techniques for stimulating conflict; manipulating the communication channels (i.e., repression of information); changing the organizational structure (i.e., changes in size or position); and altering personal behavior factors (i.e., role incongruence). Robbins stresses that the actual method to be used in either resolving or stimulating conflict must be appropriate to the situation.
Corticosterone, Reproductive Status, and Body Mass in a Cooperative Breeder, the Florida Scrub-Jay (Aphelocoma coerulescens)

In the cooperatively breeding Florida scrub-jay, nonbreeders are subordinate to the breeders with which they share a territory. Corticosterone is secreted in response to a wide range of stressors, including social stress, and suppresses reproductive and territorial behaviors in several taxa; thus, elevated baseline levels of corticosterone might be a causal mechanism of reproductive suppression. To test the hypothesis that nonbreeder Florida scrub-jays are reproductively suppressed through the actions of corticosterone, we compared corticosterone levels of nonbreeders and breeders and found no differences. However, baseline corticosterone levels only provide information about a bird's current hormonal status. Virtually all species exhibit a rapid rise in glucocorticoids in response to an acute stressor. If the adrenocortical response of nonbreeders is greater than that of breeders, this might be a mechanism whereby nonbreeders remain reproductively quiescent. We compared the responses of breeders and nonbreeders to the acute stress of being captured and held for 1 h. Both exhibited significant but equivalent increases in corticosterone titers. Because in some species heavier or fatter individuals have reduced glucocorticoid responses to stressors, we examined whether body mass was correlated with corticosterone titers. Both baseline and maximum corticosterone levels covaried with body mass, and the effect of body mass on corticosterone levels explained the increase due to capture and handling. Our data do not support the hypothesis that Florida scrub-jay nonbreeders are reproductively suppressed through the actions of corticosterone.
Linking innovation personnel: international networks among scientists

Innovation ultimately depends on people with innovation skills. The mobility of scientific and technological personnel is becoming a major mechanism for technology transfer via research networks and international collaborations, often between more and less developed regions and countries. These networks and collaborations develop their full potential through the mobility of scientific personnel and the links they create as they pursue their careers. This paper reports data from a recent study concerning more than 10,000 scientists currently working in Asian countries and Australia but who are also developing links with Africa, the Middle East, Latin America and Pacific countries. The paper focuses on joint publications as a way of indicating developing linkages. The focus is Asia but the study has relevance to other areas of the world and could be taken as a model for investigating and highlighting developing knowledge hubs in Africa and indicates areas for further public policy attention.
Orthodontic Apps for Smartphones

Background The increasing use of technology is rapidly changing our personal and professional lives. Smartphones allow users to access information in ways previously not possible and our patients may be accessing apps to source information about orthodontics and help them through their treatment. Aim To provide an overview of the orthodontic apps currently available on four of the main operating systems with emphasis on those apps targeted towards new and existing orthodontic patients as well as practising clinicians. Method Four mobile devices were used to search four mobile operating systems (Android, Apple, Blackberry and Windows) using the key words ‘braces’, ‘orthodontist’, ‘orthodontic’ and ‘orthodontics’. Results Android and Apple operating systems derived all of the apps considered relevant to orthodontic clinicians and patients. Clinician apps (11) related to orthodontic meetings (3), publications (3), products (3) and tooth ratio calculators such as Bolton (2). Patient apps (8) related to reminding patients about elastic wear (2) and aligner wear (2), dealing with orthodontic emergencies (2), orthodontic products (1) and a progress tracker of treatment (1). Conclusions Apps are available for both orthodontic clinicians and patients; however, much of the information contained within them is often not independent and even more often not validated. Patients are increasingly likely to access apps and clinicians should direct patients to those that are most appropriate and useful.
Recursive co integration analysis of foreign exchange market stability: An application for ASEAN countries

Professor, Department of Finance, National Kaohsiung University of Applied Sciences, 415 Chien Kung Road, Kaohsiung, Taiwan Tel. : 886-7-3814526 ext. 6353 Fax: 886-7-3814526 Email: cms@kuas.edu. tw Te-Chung Hu Department of Finance, National Kaohsiung University of Applied Sciences, 415 Chien Kung Road, Kaohsiung, Taiwan Meng-Huei, Su Graduate Student, Department of Finance, National Kaohsiung University of Applied Sciences 415 Chien Kung Road, Kaohsiung, Taiwan
Customer behavioural intentions towards mobile money services adoption in Ghana

ABSTRACT This study examined the determinants of mobile money service usage intentions and assessed the effect of social influence (SI) on mobile money services adoption and behavioural intentions (BIs). The sample of the study comprised 300 mobile money service users in Ghana. Guided by the conceptual framework and two theories identified to have an effect on technology adoption and consumer behaviour, eight hypotheses were developed and tested using Structural Equation Modelling Techniques. It is discovered that perceived ease of use, perceived usefulness, perceived trust and perceived cost of use have a strong influence on mobile money service usage. The study found SI to have a significant effect on the adoption and BI. Providers ensure that their mobile application services are simple to operate, fulfil specific consumers’ needs, protect consumers’ accounts to ensure trust and are affordable, hence positively influencing consumers’ adoption of services.