Miracle-dz/UniFAR-FTUs huggingface dataset:
Rethinking the role of long-acting atypical antipsychotics in the community setting

Schizophrenia is a relapsing and evolving condition, which requires treatment continuity. Increasing evidence shows that antipsychotic discontinuation is associated with relapse in most patients, and that early interventions have a positive impact on long-term outcomes. Poor adherence to antipsychotics is a major factor in the treatment of schizophrenia and a relevant risk factor for relapse. Considerable effort has been made toward improving adherence, including the development of long-acting injectable (LAI) antipsychotics. LAIs have traditionally been reserved for patients with repeated nonadherence; currently, several misconceptions prevent their more widespread use. The recent introduction of LAI formulations of atypical antipsychotics and the encouraging results in terms of the reduction in relapse rates and avoidance of hospitalization warrant a reassessment of the role of LAIs in the management of schizophrenia. This paper presents the position of a panel of nine Italian schizophrenia experts on the use of novel LAI medications, with a focus on community-based services, the prevailing setting of schizophrenia treatment in Italy. The need to change the attitude toward LAIs – no longer a treatment of last resort, but a component of multimodal strategies leading patients to remission and rehabilitation – is emphasized. The paper also presents recommendations for LAI atypical antipsychotic use in the community setting.
Online Versus Offline in the United States: Are the Media Shrinking?

We find that combined revenues for 10 major media in the United States have steadily declined as a proportion of overall economic activity or gross domestic product (GDP) from 1999 to at least 2009 (the latest year for which we have complete data). For individual media, we find a generally consistent pattern in which increasing revenues from Internet distribution are exceeded by declines in revenues from established distribution channels, with the exception of television and video games, whose revenues have so far kept pace with GDP. We also report a marked overall shift from advertiser to direct payment support for the media industries over this period. We consider four possible reasons for these revenue trends: shifts in consumer media usage, reduced appropriability due to more difficult copyright protection, inadequate advertising business models, and reduced costs due to more efficient Internet distribution. Our analysis suggests we may be entering an era of a declining size of media industries in terms of conventional measures, but not necessarily a falling supply of media products themselves.
Towards a less conservative model predictive control based on mixed ℋ2/ℋ ∞ control approach

A novel approach to the design of a less conservative model predictive control is proposed, using mixed ℋ2/ℋ∞ design method for time-invariant discrete-time linear systems. The controller has the form of a state-feedback, satisfies input and state constraints and is constructed from the solution of a set of feasibility linear matrix inequalities. The control law takes into account the disturbances naturally and the input constraint is less conservative in the sense that the full control is used. Numerical examples comparing the proposed algorithm with some existing techniques are provided to demonstrate the applicability and the advantage of the proposed algorithm.
E-Tailing in Kosovo: The Effect of Trust, Satisfaction and Service Quality in Achieving Consumer E-Loyalty

The global e-tailing industry growth in numbers of online consumers has been impressivein recent years. Because of the low entry barriers, this trend is equally evident in the number of providers. Online consumer behaviour has attracted the attention of researchers to investigate this phenomenon, who have identified e-loyalty as the most important source ofbusiness stability and profitability. Among various perspectives, the elements of trust, satisfaction, and service quality have been proposed as originators of e-loyalty. Yet, previous efforts fail to consider the combined effect of these factors, and largely ignore the occurrence of this phenomenon in developing countries. This research deducts the extant theories to develop and empirically test the hypotheses by employing a closed-ended online questionnaire. The findings show a significant positive correlation between the proposed relationships from the perspective of Kosovo online consumers, towards Kosovo e-tailers. The conclusions are drawn and future research directions are identified. DOI: 10.5901/ajis.2015. v4n3s1p502
Towards memory supporting personal information management tools

In this article, the authors discuss reretrieving personal information objects and relate the task to recovering from lapse(s) in memory. They propose that memory lapses impede users from successfully refinding the information they need. Their hypothesis is that by learning more about memory lapses in noncomputing contexts and about how people cope and recover from these lapses, we can better inform the design of personal information management (PIM) tools and improve the user's ability to reaccess and reuse objects. They describe a diary study that investigates the everyday memory problems of 25 people from a wide range of backgrounds. Based on the findings, they present a series of principles that they hypothesize will improve the design of PIM tools. This hypothesis is validated by an evaluation of a tool for managing personal photographs, which was designed with respect to the authors' findings. The evaluation suggests that users' performance when refinding objects can be improved by building personal information management tools to support characteristics of human memory. © 2007 Wiley Periodicals, Inc.
Neuro-Genetic Design Optimization Framework to Support the Integrated Robust Design Optimization Process in CE

This article describes an integrated and optimized product design framework to support the design optimization applications in concurrent engineering (CE). The significant consideration is given to show the effectiveness of hybrid approaches and how they can be used to improve the performance of integrated design optimization applications. The proposed approach is based on two-stages which are (1) the use of neural networks (NNs) and genetic algorithm (GA) with feature technology for integrated design activities and (2) the use of Taguchi’s method and GA for design parameters optimization. The first stage resulted in better integrated design solutions in terms of computational complexity and later resulted in a solution, which leads to better and more robust parameter values for multi-objective shape design optimization. The effectiveness and validity of the proposed approach are evaluated with examples.
Packet-Based Energy Efficiency of MIMO Systems With Interference Avoidance Over Frequency-Selective Fading Channels

In this paper, we analyze packet-based energy efficiencies (EE) of battery-powered multiple-input multiple-output (MIMO) mobile radio communications over frequency-selective fading channels in the presence of cochannel interference (CCI). An efficient interference avoidance (IA) technique is proposed that relies on the conveyance of interference statistics derived at the receiver. Using the IA information, which incurs very small overhead, the transmitter selects the subchannels to be used for communications and on these subchannels, channel state information (CSI) derived from time-division duplexing (TDD) operation is applied in linear precoding strategies to minimize transmit energy consumption. The minimum energy solution is conditioned on various factors such as channel coding characteristics, linear precoding beams, interference avoidance schemes, and channel realizations. A method for identifying the transmit power leading to optimization is derived and simulation results show the effectiveness of the techniques over MIMO fading channels with different CCI conditions.
Postanesthesia Care Unit Recovery Times and Neuromuscular Blocking Drugs: A Prospective Study of Orthopedic Surgical Patients Randomized to Receive Pancuronium or Rocuronium

In this study, we examined the effect of choice of neuromuscular blocking drug (NMBD) (pancuronium versus rocuronium) on postoperative recovery times and associated adverse outcomes in patients undergoing orthopedic surgical procedures. Seventy patients were randomly allocated to a pancuronium or rocuronium group. On arrival to the postanesthesia care unit (PACU) and again 30 min later, train-of-four ratios were quantified by using acceleromyography. Immediately after acceleromyographic measurements, patients were assessed for signs and symptoms of residual paresis. During the PACU admission, episodes of hypoxemia, nausea, and vomiting were recorded. The time required for patients to meet discharge criteria and the time of actual PACU discharge were noted. Forty percent of patients in the pancuronium group had train-of-four ratios <0.7 on arrival to the PACU, compared with only 5.9% of subjects in the rocuronium group (P < 0.001). Patients in the pancuronium group were more likely to experience symptoms of muscle weakness (blurry vision and generalized weakness; P < 0.001) and hypoxemia (10 patients in the rocuronium group versus 21 patients in the pancuronium group; P = 0.015) during the PACU admission. Significant delays in meeting PACU discharge criteria (50 min [45–60 min] versus 30 min [25–40 min]) and achieving actual discharge (70 min [60–90 min] versus 57.5 min [45–61 min]) were observed when the pancuronium group was compared with the rocuronium group (P < 0.001). In conclusion, our study indicates that PACU recovery times may be prolonged when long-acting NMBDs are used in surgical patients.
Cochlear implant in Cogan syndrome

Abstract Conclusions: Despite the need for special fitting strategies, improvements in speech discrimination tests support the use of cochlear implantation (CI) for patients with Cogan syndrome. Adequate preimplant counselling is mandatory, to prevent high expectations and to stress the necessity for bilateral implantation. Objective: In 60% of patients with Cogan syndrome, CI remains the only treatment option. Literature data agree that once the electrode array is properly inserted, functional outcomes are very good. Nevertheless, results may deteriorate due to progressive cochlear ossification. A few studies have documented the outcomes of CI in these patients, but none have reported the long-term results. Methods: This was a retrospective study describing the outcomes of 3 implanted patients with Cogan syndrome – among 300 adult patients who received a cochlear implant, 3 had become deaf due to Cogan syndrome. Results: In one patient the cochlear ossification advanced and the speech perception abilities worsened from the highest category to identification of words in closed set. The second patient complained of an abrupt reduction of loudness at 18 months post-implant, which required an increased electrical stimulation. The third patient reached the identification category probably due to auditory dyssynchrony, as an atypical consequence of the syndrome.
Affective Impressions and Memorability of Color-Form Combinations

In this study the authors investigate how various impressions affect the recognition of color-form pairs. They performed a preliminary study, a main study of impression rating using the semantic differential method, and a recognition experiment. On the basis of the preliminary study, the authors chose 14 appropriate pairs of adjectives and 48 color and form stimuli and used them for the main study. Factor analysis of the main study extracted three factors: Activity, Potency, and Evaluation. In the recognition test, the authors found that color-form pairs with congruent impressions in Activity or Potency were more easily recognized than pairs with incongruent impressions. In contrast, pairs with incongruent impressions in Evaluation were recognized more easily than congruent pairs. These results are discussed in relation to the assumed network representations of affective impressions that have different characteristics depending on the three factors.
Four decades of actualistic carnivore taphonomy in the Southern Neotropics: A state of the art

Fil: Mondini, Nora Mariana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Instituto de Antropologia de Cordoba. Universidad Nacional de Cordoba. Facultad de Filosofia y Humanidades. Instituto de Antropologia de Cordoba; Argentina
Acute Elevation of Blood Lead Levels Within Hours of Ingestion of Large Quantities of Lead Shot

Background: Ingestion of elemental lead foreign bodies is felt to have a low risk of clinically significant lead absorption unless gastrointestinal pathology and/or prolonged transit time are present. We present a case of ingestion of a large quantity of small diameter lead shot accompanied by rapid elevation of blood lead levels. Case Report: A 5½-year-old previously healthy girl was found eating the pellets from an ankle weight. She vomited and complained of abdominal pain. In the emergency department, she had no complaints and normal vital signs. An abdominal X-ray showed thousands of small, round, metallic density objects in the stomach. Her white blood cell count was 14,700/mm3, and the hemoglobin, mean corpuscular volume, free erythrocyte protoporphyrin, zinc protoporphyrin, biochemistry panel 21, and urinalysis were normal. She had no prior lead level for comparison. Whole-bowel irrigation was begun and she passed over 11 stools with pellets as well as other foreign bodies (erasers, bead, etc.) in the first 24 hours. Pellets were still seen on X-ray the following day so she received a high-fiber diet and bisacodyl tablets 10 mg/d. On hospital day 2, her admission blood lead (drawn 13 hours after ingestion) was reported as 57 μg/dL (2.7 μm/L) and chelation was begun with oral 2,3-dimercaptosuccinic acid 10 mg/kg 3x/d for 5 days, then 2x/d for 14 days. Her peak measured lead level was 79 μg/dL approximately 36 hours after ingestion. She excreted 2273 μg lead in the urine during her first 24 hours of chelation. Her blood lead dropped to 14.3 μg/dL by the end of chelation. She did not develop any apparent signs of lead poisoning. Conclusion: Acute elevations of blood lead concentrations may occur rapidly after ingestion of multiple small elemental lead objects.
A thermal broadening analysis of absorption spectra of the D1/D2/cytochrome b-559 complex in terms of Gaussian decomposition sub-bands.

Absorption spectra of the isolated D1/D2/cytochrome b-559 complex have been measured in the temperature range 80-300 K. All spectra were analyzed in terms of a linear combination of Gaussian bands and the thermal broadening data interpreted in terms of a model in which the spectrum of each pigment site is broadened by (a) a homogeneous component due to linear electron-phonon coupling to a low-frequency protein vibration and (b) an inhomogeneous component associated with stochastic fluctuations at each pigment site. In order to obtain a numerically adequate description of the absorption spectra, a minimum number of five sub-bands is required. Further refinement of this sub-band description was achieved by taking into account published data from hole burning and absorption difference spectroscopy. In this way, both a six sub-band description and a seven sub-band description were generated. In arriving at the seven sub-band description, the original five sub-band wavelength positions were essentially unchanged. Thermal broadening analysis of the seven sub-band description yielded data which displayed the closest correspondence with the literature observations. The wavelength positions of the sub-bands were near 661, 667, 670, and 675 nm, with two bands near 680 and 684 nm. The two almost isoenergetic sub-bands near 680 nm, identified as P680 and pheophytin, have optical reorganization energies around 40 and 16 cm-1, respectively. All other sub-bands, identified as accessory pigments, have optical reorganization energies close to 16 cm-1. (ABSTRACT TRUNCATED AT 250 WORDS)
The Psychosocial Impact of Severe Hypoglycemic Episodes on Spouses of Patients With IDDM

OBJECTIVE No previous studies have examined the psychosocial impact of severe hypoglycemic episodes in IDDM patients on their spouses. This study compared spouses of IDDM patients with and without a history of recent severe hypoglycemia (SH) using traditional measures of psychosocial status and marital conflict, as well as diabetes-specific measures. RESEARCH DESIGN AND METHODS A total of 61 nondiabetic spouses (23 wives and 38 husbands) of IDDM patients participated in the study. Spouses completed a battery of traditional psychometric measures (depression, anxiety, marital conflict) and diabetes-specific measures (fear of hypoglycemia, marital conflict over diabetes, sleep disturbance caused by hypoglycemia). Scores of spouses of IDDM patients with and without a recent history of SH were compared with t tests. RESULTS Spouses of IDDM patients with and without a recent history of SH showed no differences on traditional psychometric measures of depression, anxiety, and marital conflict. However, spouses of patients with a recent history of SH showed significantly more fear of hypoglycemia, marital conflict about diabetes management, and sleep disturbances caused by hypoglycemia. Exploratory analyses of variance (ANOVAs) found no differences on psychometric measures between wives and husbands, with the exception that husbands of SH patients reported more sleep disturbance. Nondiabetic spouses, on average, showed greater fear of hypoglycemia than their diabetic partners. CONCLUSIONS Although SH in IDDM patients can have a significant impact on the psychosocial status of their spouses, in this study the negative impact was restricted to areas of life that are directly related to diabetes and its management. Thus, SH per se is not necessarily associated with significant increases in spousal anxiety, depression, or marital conflict, but may be associated with types of diabetes-specific psychosocial distress that are not easily identified by traditional psychometric measures.
Histone deacetylase inhibitors: Understanding a new wave of anticancer agents

Cancer is as much an epigenetic disease as it is a genetic and cytogenetic disease. The discovery that drastic changes in DNA methylation and histone modifications are commonly found in human tumors has inspired various laboratories and pharmaceutical companies to develop and study epigenetic drugs. One of the most promising groups of agents is the inhibitors of histone deacetylases (HDACs), which have different biochemical and biologic properties but have a single common activity: induction of acetylation in histones, the key proteins in nucleosome and chromatin structure. One of the main mechanisms of action of HDAC inhibitors is the transcriptional reactivation of dormant tumor‐suppressor genes, such as p21WAF1. However, their pleiotropic nature leaves open the possibility that their well‐known differentiation, cell‐cycle arrest and apoptotic properties are also involved in other functions associated with HDAC inhibition. Many phase I clinical trials indicate that HDAC inhibitors appear to be well‐tolerated drugs. Thus, the field is ready for rigorous biologic and clinical scrutiny to validate the therapeutic potential of these drugs. Our current data indicate that the use of HDAC inhibitors, probably in association with classical chemotherapy drugs or in combination with DNA‐demethylating agents, could be promising for cancer patients. © 2004 Wiley‐Liss, Inc.
Computer-assisted LISS plate osteosynthesis of proximal tibia fractures: Feasibility study and first clinical results

Fluoroscopy is the most common tool for the intraoperative control of long-bone fracture reduction. Limitations of this technology include high radiation exposure for the patient and the surgical team, limited visual field, distorted images, and cumbersome verification of image updating. Fluoroscopy-based navigation systems partially address these limitations by allowing fluoroscopic images to be used for real-time surgical localization and instrument tracking. Existing fluoroscopy-based navigation systems are still limited as far as the virtual representation of true surgical reality is concerned. This article, for the first time, presents a reality-enhanced virtual fluoroscopy with radiation-free updates of in situ surgical fluoroscopic images to control metaphyseal fracture reduction. A virtual fluoroscopy is created using the projection properties of the fluoroscope; it allows the display of detailed three-dimensional (3D) geometric models of surgical tools and implants superimposed on the X-ray images. Starting from multiple registered fluoroscopy images, a virtual 3D cylinder model for each principal bone fragment is constructed. This spatial cylinder model not only supplies a 3D image of the fracture, but also allows effective fragment projection recovery from the fluoroscopic images and enables radiation-free updates of in situ surgical fluoroscopic images by non-linear interpolation and warping algorithms. Initial clinical experience was gained during four tibia fracture fixations that were treated by LISS (Less Invasive Stabilization System) osteosynthesis. In the cases operated on, after primary image acquisition, the image intensifier was replaced by the virtual reality system. In all cases, the procedure including fracture reduction and LISS osteosynthesis was performed entirely in virtual reality. A significant disadvantage was the unfamiliar operation of this prototype software and the need for an additional operator for the navigation system.
Physical activity level at work and risk of chronic low back pain: A follow-up in the Nord-Trøndelag Health Study

Background Physical activity in leisure time seems to reduce the risk of low back pain, but it is not known whether occupational activity, as recorded in a representative working population, produces a higher or lower risk. Objective To study associations between physical activity level at work and risk of chronic low back pain. Methods Associations were examined in a Norwegian prospective study using data from the HUNT2 and HUNT3 surveys carried out in the whole county of Nord-Trøndelag. Participants were 7580 women and 7335 men who supplied information about physical activity level at work. Levels considered were sedentary work, work involving walking but no heavy lifting, work involving walking and heavy lifting, and particularly strenuous physical work. Nobody in the cohort was affected by chronic low back pain at baseline. After 11 years, participants reported whether they suffered from chronic low back pain. Generalized linear modelling with adjustment for potential confounders was applied to assess associations with risk factors. Results In age-adjusted analyses both women and men showed statistically significant associations between physical activity at work and risk of chronic low back pain, suggesting positive relationships. For particularly strenuous physical work the relative risk of chronic low back pain was 1.30 (95% CI: 1.00–1.71) in women and 1.36 (95% CI 1.17–1.59) in men, compared to sedentary work. Women still showed a general association with activity level after adjustment for education, leisure time physical activity, BMI, smoking and occupational category. In men, the higher risk was only maintained for particularly strenuous work. Conclusion In this cohort, women had a higher risk of chronic low back pain with work involving walking and heavy lifting or particularly strenuous work, compared to sedentary work. Men participating in particularly strenuous work also experienced a higher risk of chronic low back pain.