Miracle-dz/UniFAR-FTUs huggingface dataset:
Management of patients with patellofemoral pain syndrome using a multimodal approach: a case series.

STUDY DESIGN A case series of consecutive patients referred to physical therapy with patellofemoral pain syndrome (PFPS). BACKGROUND Physical therapists often treat patients with PFPS, yet there is currently no consensus as to the most effective management strategies. The purpose of this case series is to describe the outcomes of patients referred to physical therapy with PFPS who were treated with a multimodal approach. CASE DESCRIPTION Five patients were treated with a combination of thrust and nonthrust manipulation directed at the joints of the lower quarter, trunk and hip stabilization exercises, patellar taping, and foot orthotics. Outcome measures used to capture change in patient status included the Numeric Pain Rating Scale, the Kujala Anterior Knee Pain Scale, the Lower Extremity Functional Scale, and the Global Rating of Change. OUTCOMES Five patients (median age, 15 years; range, 14-50 years) with a median duration of knee pain for 8 months (range, 3-24 months) were included in this prospective case series. Four (80%) of the 5 patients demonstrated decreased pain and a clinically significant improvement in function. These gains in function were maintained at a 6-month follow-up. DISCUSSION Although a cause-and-effect relationship cannot be inferred from a case series, the outcomes achieved by the patients are consistent with studies incorporating manual physical therapy, exercise, patellar taping, and orthotic prescription to the management of conditions of the lower extremity. Further randomized controlled trials should be performed to determine the effectiveness of this multimodal approach for the management of individuals with PFPS.
Moderate renal insufficiency and the risk of cardiovascular mortality: results from the NHANES I.

BACKGROUND Conflicting evidence exists concerning whether renal insufficiency is an independent risk factor for cardiovascular disease in the general population. The objective of this study was to determine whether moderate renal insufficiency was associated with total and cardiovascular mortality, independent of traditional cardiovascular risk factors, in a community sample representative of the U.S. general non-institutionalized population. METHODS Participants in the U.S. First National Health and Nutrition Examination Survey (NHANES I, 1974-1975) and NHANES I Epidemiologic Follow-up Study (NHEFS, 1992, 18 year follow-up) were evaluated. The primary analysis was limited to 2352 adults with complete data, and no baseline cardiovascular disease. A creatinine of 104 to 146 micromol/L in women, and 122 to 177 micromol/L in men (approximate glomerular filtration rate of 30 to 60 mL/min/1.73 m2) was defined as moderate renal insufficiency. Supplementary analyses included participants with marked renal impairment and baseline cardiovascular disease. RESULTS The unadjusted hazard ratio for moderate renal insufficiency compared to preserved renal function was significant for total mortality (hazard ratio 1.7; 95% confidence interval 1.3 to 2.2), and for cardiovascular mortality (2.2; 1.5 to 3.1). After adjustment for traditional cardiovascular risk factors, there was no independent association between moderate renal insufficiency and total mortality (1.0; 0.8 to 1.4), or cardiovascular mortality (1.2; 0.8 to 1.8). These results were consistent in supplementary analyses. CONCLUSIONS These results do not support moderate renal insufficiency as an independent risk factor for cardiovascular disease in the general population. The association between moderate renal insufficiency and cardiovascular disease, demonstrated in other epidemiologic studies, appears to be due to co-occurrence of renal insufficiency with traditional cardiovascular risk factors.
Maternal Serum Adiponectin at 11–13 Weeks of Gestation in Preeclampsia

Objective: To determine whether the maternal serum levels of adiponectin in the first trimester of pregnancy are altered in cases that develop preeclampsia (PE) and whether the levels are related to pregnancy-associated plasma protein-A (PAPP-A) and uterine artery pulsatility index (PI). Methods: Serum adiponectin, PAPP-A and uterine artery PI were measured at 11–13 weeks in 90 cases that developed PE, including 30 that required delivery before 34 weeks (early PE) and 300 unaffected controls. The median adiponectin, PAPP-A and uterine artery PI multiple of the unaffected median (MoM) in the outcome groups were compared. Results: In both early PE and late PE, compared to controls, uterine artery PI MoM was increased (1.32 and 1.05 vs. 1.02) and PAPP-A MoM was decreased (0.61 and 0.84 vs. 1.00), whereas adiponectin MoM was increased in early PE but not in late PE (1.32 and 1.05 vs. 1.02). In the PE group, there was no significant association between adiponectin and PAPP-A or uterine artery PI. Serum adiponectin did not improve the performance of screening for PE provided by a combination of the maternal factors, uterine artery PI and serum PAPP-A. Conclusion: Serum adiponectin levels at 11–13 weeks are increased in women that develop early PE by a mechanism unrelated to impaired placentation.
‘ART’ A Computer Code To Assist The Design Of Refrigeration and A/C Equipment

In this paper a new computer code: ART (Advanced Refrigeration Technologies), recently developed at the Universidad Politecnica de Valencia is presented. The main features of the program are fast calculation and accurate evaluation of the refrigeration unit performance. The paper describes the main characteristics of the global model and of the submodels of the main components considered in ART, as well as of the concerned numerical strategies, showing the capabilities of the code to assist the design of refrigeration equipment. The model takes into account all the components of the system: compressor, HEs, piping and accessories. For the main components different submodels with different levels of accuracy are included in order to allow the user to concentrate in the optimization of the desired component. ART is able to calculate a complete refrigeration system, including the detailed modeling of the HEs, in less than 20s. Once minimally adjusted, typical predicted results show a good agreement with experimental results with maximum deviations around 5%.
Targeted massively parallel sequencing of angiosarcomas reveals frequent activation of the mitogen activated protein kinase pathway

Angiosarcomas are rare malignant mesenchymal tumors of endothelial differentiation. The clinical behavior is usually aggressive and the prognosis for patients with advanced disease is poor with no effective therapies. The genetic bases of these tumors have been partially revealed in recent studies reporting genetic alterations such as amplifications of MYC (primarily in radiation-associated angiosarcomas), inactivating mutations in PTPRB and R707Q hotspot mutations of PLCG1. Here, we performed a comprehensive genomic analysis of 34 angiosarcomas using a clinically-approved, hybridization-based targeted next-generation sequencing assay for 341 well-established oncogenes and tumor suppressor genes. Over half of the angiosarcomas (n = 18, 53%) harbored genetic alterations affecting the MAPK pathway, involving mutations in KRAS, HRAS, NRAS, BRAF, MAPK1 and NF1, or amplifications in MAPK1/CRKL, CRAF or BRAF. The most frequently detected genetic aberrations were mutations in TP53 in 12 tumors (35%) and losses of CDKN2A in 9 tumors (26%). MYC amplifications were generally mutually exclusive of TP53 alterations and CDKN2A loss and were identified in 8 tumors (24%), most of which (n = 7, 88%) arose post-irradiation. Previously reported mutations in PTPRB (n = 10, 29%) and one (3%) PLCG1 R707Q mutation were also identified. Our results demonstrate that angiosarcomas are a genetically heterogeneous group of tumors, harboring a wide range of genetic alterations. The high frequency of genetic events affecting the MAPK pathway suggests that targeted therapies inhibiting MAPK signaling may be promising therapeutic avenues in patients with advanced angiosarcomas.
Motor unit activation strategy during a sustained isometric contraction of finger flexor muscles in elite climbers

Abstract The aim of the study was to evaluate, by an electromyographic (EMG) and mechanomyographic (MMG) combined approach, whether years of specific climbing activity induced neuromuscular changes towards performances related to a functional prevalence of fast resistant or fast fatigable motor units. For this purpose, after the maximum voluntary contraction (MVC) assessment, 11 elite climbers and 10 controls performed an exhaustive handgrip isometric effort at 80% MVC. Force, EMG and MMG signals were recorded from the finger flexor muscles during contraction. Time and frequency domain analysis of EMG and MMG signals was performed. In climbers: (i) MVC was higher (762 ± 34 vs 512 ± 57 N; effect size: 1.64; confidence interval: 0.65–2.63; P < 0.05); (ii) endurance time at 80% MVC was 43% longer (34.2 ± 3.7 vs 22.3 ± 1.5 s; effect size: 1.21; confidence interval: 0.28–2.14; P < 0.05); (iii) force accuracy and stability were greater during contraction (P < 0.05); (iv) EMG and MMG parameters were higher throughout the entire isometric effort (P < 0.05). Collectively, force, EMG and MMG combined analysis revealed that several years of specific climbing activity addressed the motor control system to adopt muscle activation strategies based on the functional prevalence of fast resistant motor units.
Fledgling Psychopathy in the Classroom: ADHD Subtypes, Psychopathy, and Reading Comprehension in a Community Sample of Adolescents

The current study explores characteristics that are associated with fledgling psychopathy and educational outcomes relating to reading comprehension performance in a community sample of 432 middle school students. Latent class analysis (LCA) produced a four-class solution. Class 1 was a large (71.5% of sample) ‘‘control’’ group of youths with no attention/hyperactivity deficits and the highest reading comprehension scores. Class 2 was 11.6% of the sample and was consistent with traits associated with attention deficit hyperactivity disorder (ADHD) predominantly inattentive type. Class 3 was 7.4% of the sample and was consistent with traits associated with ADHD predominantly hyperactive—impulsive type. Class 4 was 9.5% of the sample and was consistent with traits associated with ADHD combined type. Classes 2 and 4 were characterized by elevated levels of psychopathic and callous-unemotional (CU) traits and lower educational performance. This study extends the utility of fledgling psychopathy to educational outcomes, which has broad implications for adolescent development, delinquency, and youth violence.
INCAPACIDADE FUNCIONAL EM IDOSOS INSTITUCIONALIZADOS

Os objetivos do estudo foram caracterizar o grau de incapacidade funcional para a realizacaode atividades basicas da vida diaria e determinar a prevalencia e os fatores associadosa incapacidade funcional em idosos institucionalizados. Realizou-se estudo transversal dotipo censo das instituicoes de longa permanencia para idosos de Pelotas, Rio Grande doSul. O desfecho, incapacidade funcional, foi avaliado pelo Indice de Katz, e definido comoa necessidade de ajuda parcial ou total para cada uma das seis atividades basicas da vidadiaria investigadas. As exposicoes avaliadas foram sexo, idade, escolaridade e nivel de atividadefisica. Empregou-se o modelo de regressao de Poisson com variância robusta nas analisesbruta e ajustada. A amostra foi composta por 393 sujeitos com idade igual ou superiora 60 anos. A prevalencia de incapacidade funcional em, no minimo, uma atividade da vidadiaria foi de 79,4% (IC95%: 75,4; 83,4), sendo que, 10,9% apresentaram incapacidade emapenas uma atividade basica, 28,5% tiveram de duas a quatro atividades com incapacidadefuncional e 40,0% relataram cinco ou seis atividades basicas com incapacidade funcional.Os idosos apresentaram maior percentual de independencia para comer (73,3%) e menorpercentual de independencia para tomar banho (26,7%). Na analise ajustada, mulheres,idosos com menor escolaridade, idades avancadas e inativos fisicamente apresentarammaior numero medio de atividades da vida diaria acumuladas com incapacidade funcional.Observou-se alta prevalencia de incapacidade funcional entre idosos institucionalizados. Ainatividade fisica foi o fator mais fortemente associado a incapacidade funcional.
Percepção Materna sobre a higiene bucal de Bebês: Umestudo no Hospital Alcides Carneiro, Campina Grande-PB

A magnitude e severidade da carie dentaria em dentes deciduos constituem-se ainda em grave problema de saude e necessita receber atencao especial. Reconhecendo a importância dos pais na prevencao da carie dentaria, este trabalho objetivou verificar o conhecimento e percepcao que um grupo de maes tem sobre a higiene bucal de seus bebes. Foi realizado um estudo observacional, com abordagem indutiva, sendo a amostra foi composta por um grupo de 80 maes cujos filhos eram atendidos no Hospital Alcides Carneiro em Campina Grande-PB. Elaborou-se um questionario especifico contendo os dados socio-demograficos e questoes relativas a higiene bucal em bebes. Dentre os principais resultados observou-se que apenas 32, 5 porcento das maes tinha recebido informacoes sobre a higiene bucal do seu filho, sendo o pediatra a principal fonte de informcoes. A higiene bucal era realizada po r73, 8 porcento das maes e 50, 8 porcento iniciaram antes da erupcao do primeiro dente deciduo (AU)
Bioequivalence evaluation of two brands of enalapril 20mg tablets (narapril and renitec) in healthy human volunteers

The bioequivalence of two brands of enalapril 20 mg tablets was demonstrated in 24 healthy human volunteers after a single oral dose in a randomized cross‐over study, conducted at IPRC, Amman, Jordan. Reference (Renitec, MSD, Netherlands) and test (Narapril, Julphar, UAE) products were administered to fasted male volunteers; blood samples were collected at specified time intervals, plasma separated and analysed for enalapril and its active metabolite (enalaprilat) using a validated LC‐MS/MS method at Cartesius Analytical Unit, Institute of Biomedical Sciences, USP, Sao Paulo, Brazil. The pharmacokinetic parameters AUC0−t, AUC0−∝, Cmax,Tmax,T1/2 and elimination rate constant were determined from plasma concentration‐time profile for both formulations and were compared statistically to evaluate bioequivalence between the two brands, using the statistical modules recommended by FDA. The analysis of variance (ANOVA) did not show any significant difference between the two formulations and 90% confidence intervals fell within the acceptable range for bioequivalence. Based on these statistical inferences it was concluded that the two brands exhibited comparable pharmacokinetic profiles and that Julphar's Narapril is bioequivalent to Renitec of MSD, Netherlands. Copyright © 2003 John Wiley & Sons, Ltd.
Experimental determination of the equilibria: rutile + magnesite = geikielite + CO2 and zircon + 2 magnesite = baddeleyite + forsterite + 2 CO2

Abstract The P-T conditions of both equilibria were determined precisely by reversal experiments in a piston-cylinder apparatus. On the basis of 8 experiments, brackets for the rutile-magnesite-geikielite equilibrium are 7.0-7.1 kbar at 800 °C, 8.6-8.7 kbar at 850 °C, and 10.5-10.7 kbar at 900 °C. On the basis of 9 experiments, brackets for the zircon-magnesite-baddeleyite-forsterite equilibrium are 7.1- 7.7 kbar at 800 °C, 9.2-9.4 kbar at 850 °C, and 10.7-10.9 kbar at 900 °C. Considering experimental uncertainties in P (±300 bars) and T (±3 °C), equilibrium curves calculated from both the Berman and the Holland and Powell databases pass through all brackets. Molar Gibbs free energy of formation from the elements at 1 bar and 298 K for geikielite and zircon, derived from the experiments and consistent with the Berman database, are -1481.94 ± 0.67 kJ and -1917.54 ± 1.25 kJ, respectively. Corresponding values consistent with the Holland and Powell database are -1479.30 ± 0.74 kJ and -1918.47 ± 1.49 kJ. Application of the two equilibria indicate that: (1) the mole fraction of CO2 in fluid was 0.54-1.00 when geikielite and baddeleyite formed during contact metamorphism of siliceous dolomites in the Ballachulish aureole, Scotland; (2) the activity of CO2 could have been as low as 2.10-5 during ultra-high pressure metamorphism of magnesite-bearing ecologites; and (3) the activity of CO2 was <0.18 during one instance of mantle metasomatism.
[Type of syndrome, location, size and etiology of capsular lacunar infarction].

We investigated the types of clinical syndrome, location, sizes and presumed causes of 49 patients with capsular lacunar infarction. Clinical syndromes were classified according to Fisher's criteria into pure motor hemiparesis (PM), sensorimotor stroke (SM) and ataxic hemiparesis (AH) including dysarthria clumsy hand syndrome. Cases who had higher brain dysfunctions or brainstem syndromes were excluded. The size of infarcts was expressed as the volume on brain CT. All patients underwent 12-lead ECG and 2-dimension echocardiography. Twenty three patients (47%) underwent angiography or carotid ultrasonography. Lesion sites on CT were divided into three groups, i.e., perforating branch of ACA (PACA), perforating branch of MCA (PMCA) and anterior choroidal artery (AC). Lesion sizes of AH were significantly smaller than those of SM and tended to be smaller than those of PM. In AH patients, no cardioembolic sources nor large arterial lesions could be detected, whereas 40% in SM patients and 30% in PM patients had cardioembolic sources and 33% in SM patients and 75% of PM patients had large arterial lesions. The lesion volume was classified into two groups, larger and smaller than 1 ml. The larger volume group had more frequent cardioembolic sources than the small volume group (42% and 17% respectively, p less than 0.05), but no significant difference in frequency of large artery lesions was found among the two groups. Patients with "large striatocapsular infarct" had frequent cardiac and arterial lesions (60% and 40% respectively). Patients with AC territory infarction had more infrequent but not significant cardiac and arterial lesions than patients with PMCA territory infarction. All patients with PACA territory infarction presented PM. (ABSTRACT TRUNCATED AT 250 WORDS)
Vivencias da gravidez relatadas por mulheres com anemia falciforme : um estudo clinico-qualitativo

As propostas de politicas de saude para a populacao negra tem uma historia recente no cenario politico brasileiro, com um destaque especial para o Programa Nacional de Anemia Falciforme. A anemia falciforme e a doenca hereditaria mais comum no Brasil e constitui um problema de saude publica. Alguns trabalhos buscaram destacar a relevância do enfoque epidemiologico da anemia falciforme entre as mulheres e suas repercussoes na saude reprodutiva dessa populacao. Mulheres portadoras de anemia falciforme apresentam maior risco de abortamento e complicacoes durante o parto, fatos que geram repercussoes emocionais na gestante. O objetivo desta pesquisa foi conhecer significados das vivencias da gravidez relatados por mulheres portadoras de anemia falciforme. Utilizamos o metodo clinico-qualitativo, tendo sido a amostra fechada por saturacao das informacoes, composta por nove pacientes acompanhadas no Ambulatorio de Alto Risco e na enfermaria de patologias obstetricas do Centro de Atencao Integral a Saude da Mulher (CAISM). Suas idades variaram de 19 a 35 anos de idade, com periodos gestacionais entre 16 e 30 semanas. Foram realizadas entrevistas semidirigidas com questoes abertas, gravadas, transcritas e submetidas a analise qualitativa de conteudo. Os resultados foram categorizados em topicos, dos quais elegemos dois para discussao neste trabalho: (1) o significado da maternidade parece permitir que o desejo de ser mae se manifeste mais forte do que sentimentos comuns de medo relacionados a doenca e os seus agravamentos; (2) a presenca da doenca no cotidiano dessas mulheres, as varias complicacoes e internacoes foram percebidas de maneira ambivalente, como um ? mal necessario? Como esperado, o apoio de familiares e de profissionais da saude foram cruciais para que a gestacao dessas mulheres fosse enfrentada de forma mais tranquila. O estudo sugere que apesar da vivencia de angustias existenciais e psicologicas que envolvem normalmente a gravidez, das limitacoes da doenca para o desempenho de funcoes profissionais e sociais e do conhecimento das possibilidades de complicacoes clinicas para a mae e/ou para o bebe, estes sentimentos nao interferiram na manifestacao do desejo do exercicio da maternidade Abstract
Isolation of Microorganisms from Antarctic Soils and Their Use as Possible Corrosion Inhibitors

In this study microorganisms from Antarctic soils were isolated using different selective nutrient media. The soils were collected from different habitats of Livingston Island. The microorganisms were isolated and purified to pure culture. The isolated microorganisms were micro-morphologically and macromorphologically characterized. The results obtained suggested that despite the extreme Antarctic environment the diversity of soil microorganisms was considerably high. Some of the isolated microorganisms were able to protect corrosion. The effect of the studied microorganisms on the corrosive stability of steel samples was studied by micrometer method. The corrosive activity was confirmed by microscopic pictures of the treated steel samples.
Relación del autoconcepto físico con las conductas de consumo de alcohol y tabaco en adolescentes

El pr oposito de este estudio ha sido comprobar la relacion del genero, el consumo de tabaco y alcohol y la practica fisico-deportiva en el autoconcepto fisico en estudiantes adolescentes espanoles de educacion fisica. La muestra estuvo compuesta por 1.008 alumnos (M edad = 15.94, DT = .89) a los que se les paso el cuestionario de autoconcepto fisico (PSQ). Tras distintos analisis de correlacion, univariantes, multivariantes y de regresion, los resultados revelaron que el autoconcepto fisico presentaba relaciones con el genero, el consumo de tabaco y alcohol y la practica fisico-deportiva. La mejor percepcion de la imagen corporal se observo en las mujeres que no fumaban y los no practicantes de actividad fisico-deportiva. Por otro lado, el ser varon y practicar deporte fue lo que mas predecia el autoconcepto fisico, entendiendo por este la autovaloracion fisica. Como conclusion, este estudio muestra la relevancia que tiene el resultado de que la accion de fumar se asocia con una buena imagen corporal y que la practica del deporte se realiza para fomentar una apariencia fisica mas positiva y acorde con los canones de belleza establecidos en nuestra sociedad actual.
Investigating Children's Passwords using a Game-based Survey

This work describes how a simple Android game was used to study password and username creation with children aged 7 and 8. Children answered questions, made a username and password, and then later used these to log in. The novelty is in the use of the approach as well as in the findings. The findings confirm earlier work in regards to password length, suggesting six characters as adequate, and provide preliminary evidence that most children use familiar items in password and especially username creation.