Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of the vertical emission profiles on background gas-phase pollution simulated from the EMEP emissions over Europe

Abstract. Five one-year air quality simulations over a domain covering Europe have been performed using the CHIMERE chemistry transport model and the EMEP emission dataset for Europe. These five simulations differ only by the representation of the effective emission heights for anthropogenic emissions: one has been run using the EMEP standard recommendations, three others with vertical injection profiles derived from the EMEP recommendations but multiplying the injection height by 0.75, 0.50 and 0.25, respectively, while the last one uses vertical profiles derived from the recent literature. It is shown that using injection heights lower than the EMEP recommendations leads to significantly improved simulation of background SO 2 , NO 2 and O 3 concentrations when compared to the Airbase station measurements.
Impaired lymphocyte proliferation in human acute pancreatitis.

PURPOSE We evaluated the proliferative response of lymphocytes to phytohemagglutinin P (PHA P), concanavalin A (Con A), and pokeweed mitogen (PWM) during the course of acute pancreatitis. PATIENTS AND METHODS Sixty consecutive patients with acute pancreatitis were studied within 48 h of the onset of pain, and 16 of them were also studied 1 month after complete recovery. According to the Atlanta criteria, 21 patients had severe disease and 39 had mild disease. Fifteen healthy subjects and 11 patients with nonpancreatic acute abdomen were studied as controls. In 12 patients with acute pancreatitis the lymphocyte proliferation after stimulation with the three mitogens was also assessed in autologous and heterologous plasma. RESULTS The lymphocyte proliferative response to optimal doses of PHA P, Con A, and PWM was significantly lower (p < 0.001) in acute pancreatitis patients (mean +/- SD; PHA P 74,310 +/- 22,960 cpm; Con A 64,669 +/- 20,188 cpm; PWM 26,714 +/- 6,436 cpm) than in healthy subjects (PHA P 111,316 +/- 12,044 cpm; Con A 96,276 +/- 12,327 cpm; PWM 33,957 +/- 3,601 cpm). Patients with nonpancreatic acute abdomen had a significantly higher lymphocyte proliferative response to PHA P and Con A than acute pancreatitis patients (PHA P p < 0.002; Con A p < 0.01; PHA P 91,116 +/- 22,995 cpm; Con A 77,879 +/- 19,083 cpm). In patients with acute pancreatitis, lymphocyte proliferation stimulated with PHA P and Con A was significantly lower (PHA P p < 0.005; Con A p < 0.001) in those with severe disease (PHA P 63,190 +/- 15,157 cpm; Con A 52,813 +/- 13,324 cpm) than in those with mild disease (PHA P 80,298 +/- 24,340 cpm; Con A 71,052 +/- 20,490 cpm). In the group of 16 patients studied during the initial phase of acute pancreatitis and 1 month after recovery, lymphocyte proliferation significantly improved after remission of the disease but remained impaired compared with that of healthy subjects. No difference was found in the lymphocyte proliferation of the 12 patients with acute pancreatitis assayed in autologous and heterologous plasma. CONCLUSIONS The peripheral lymphocyte proliferative response to mitogen stimulation in patients with acute pancreatitis was decreased during the early phases of the disease.
ChREBP Rather than SHP Regulates Hepatic VLDL 2 Secretion 3

The regulation of hepatic very-low-density lipoprotein (VLDL) secretion plays an 12 important role in the pathogenesis of dyslipidemia and fatty liver diseases. VLDL is controlled by 13 hepatic microsomal triglyceride transfer protein (MTTP). Mttp is regulated by carbohydrate 14 response element binding protein (ChREBP) and small heterodimer partner (SHP). However, it is 15 unclear whether both coordinately regulate Mttp expression and VLDL secretion. Here, adenoviral 16 overexpression of ChREBP and SHP in rat primary hepatocytes induced and suppressed Mttp 17 mRNA, respectively. However, Mttp induction by ChREBP was much more potent than 18 suppression by SHP. Promoter assays of Mttp and the liver type pyruvate kinase gene revealed that 19 SHP and ChREBP did not affect the transactivity of each other. Mttp mRNA and protein levels of 20 Shp/– mice were similar to those of wild-type; however, those of Chrebp–/–Shp–/– and Chrebp–/– mice 21 were much lower. Consistent with this, the VLDL particle number and VLDL secretion rates in Shp– 22 /–mice were similar to wild-type, but were much lower in Chrebp–/– and Chrebp–/–Shp–/–mice. These 23 findings suggested that ChREBP rather than SHP regulates VLDL secretion and that ChREBP and 24 SHP do not affect the transactivities of each other. 25
Elevated erythropoietin levels in cord blood of newborns with Down's syndrome.

Plasma erythropoietin (Ep) was determined in umbilical cord blood in 18 infants with Down's syndrome. The 16 infants with Down's syndrome who were delivered after labor had significantly elevated plasma Ep levels compared to 36 control infants born after labor (p < 0.001). Six of the ten infants with Down's syndrome who had their packed cell volume (PCV) measured in the first 24 h of life were polycythemic based on a PCV of > or = 0.65. The presence of congenital heart disease in 9 of the 18 infants with Down's syndrome was not associated with a higher plasma Ep or PCV levels. Plasma Ep was correlated with neonatal PCV in the combined group of control and Down's syndrome infants (p = 0.003). Increased plasma Ep levels observed in infants with Down's syndrome suggested chronic fetal hypoxemia as a likely explanation for the high incidence of neonatal polycythemia observed in this group.
Space-Time Signal Optimization for SWIPT: Linear Versus Nonlinear Energy Harvesting Model

In simultaneous wireless information and power transfer systems, optimization of transmit signals is critical to system performance. Although the optimization problem can be efficiently solved under a linear energy harvesting model, the obtained solution may not work well in practice, since the energy harvester contains nonlinear elements, such as diodes. On the other hand, while a nonlinear model can be used to capture the dynamics of energy harvesting circuits, it introduces additional complexity at the optimization stage. Specifically, under a nonlinear model, traditional convex optimization is not applicable, since the energy harvesting function is fractional. To address this challenge, this letter first derives an optimal solution for static channels by introducing pseudo-inverse of the nonlinear model. Then, an iterative algorithm that converges to a sub-optimal solution is proposed for time varying channels. With the developed methods, the performance-complexity tradeoff between linear and nonlinear models is illustrated.
Hypogonadism in male thalassemia major patients: pathophysiology, diagnosis and treatment

Failure of pubertal growth, delay or absence of sexual development, infertility and sexual dysfunction due to hypogonadism and defective spermatogenesis are frequent and well recognized disturbances among male patients with transfusion dependent (TD) thalassaemia major (β-thal). These problems are attributed mainly to the damage caused by chronic anaemia and the deposition of excess iron in the pituitary gland and testicles. This is a short review of male pubertal disorders in patients with β-thal written by pediatric endocrinologists and haematologists with an interest and active involvement, in the diagnosis and management of these complications in this group of patients. A vigilant clinical evaluation of growth and puberty, as well as an appropriate hormonal evaluation in poly-transfused (TD β-thal) patients is strongly recommended for early detection and treatment of endocrine dysfunction. Of crucial importance also, is the implementation of an efficient chelation regime from early life, to prevent severe iron load and permanent damage to the endocrine glands, particularly those responsible for gonadal function. (www.actabiomedica.it)
miRNA-convergent gene fusions

ABSTRACT In a recent study published in Nature Communications, we showed that intron-encoded microRNA genes (miRNA) are frequent partners of fusion genes in the cancer genome. Analyzed from a functional rather than structural perspective, these rearrangements represent a new class of fusions we called “miRNA-convergent fusions”.
A Rare Insertion Site for Abductor pollicis longus and Extensor pollicis brevis Muscles

During an investigation performed on cadaver forearms in the anatomy department, an unusual insertion of the abductor pollicis longus (APL) muscle together with the extensor pollicis brevis (EPB) muscle was encountered unilaterally in a 40-year-old male cadaver forearm. APL originated from the posterior ulnar surface distal to the anconeus, the adjoining interosseous membrane and middle third of the posterior radial surface. It lay distal to the supinator muscle and close to the EPB, while the EPB arose from the posterior radial surface and from the adjacent interosseous membrane. These muscles were inserted to the palmar side of the base of the first metacarpal bone together. To our knowledge, this variation has not been cited in recent medical literature.
Olive Oil Supplementation in Healthy Adults: Effects in Cell Membrane Fatty Acid Composition and Platelet Function

Ten healthy volunteers were given a daily supplement of 30 g olive oil for 6 weeks in order to evaluate how it would affect cell membrane composition and ultimately platelet function. Fasting blood and cheek cell samples were taken before commencing the study, after 21 and 42 days of supplementation and also at 30 days after finishing the supplement (washout). C18:1n-9 was significantly increased (p < 0.01) in platelet and cheek cell phospholipids. Erythrocytes were not good markers for C18:1n-9 intake and no significant change was found in this tissue. There was a small nonsignificant decrease in platelet phospholipid 20:4n-6 after the supplementation, in accordance with previously published results. C18:1n-9 did not persist in platelet membranes after the volunteers stopped consuming the olive oil supplement, but in erythrocytes a significant increase (p < 0.05) was found after the washout period. None of these changes in fatty acid composition in the different tissues were related to significant changes in serum cholesterol-related variables or in clotting factors or adenosine diphosphate-induced platelet aggregation.
Lesions of the afferent catecholaminergic pathways inhibit the temporal activation of the CRH and POMC gene expression and ACTH release induced by human interleukin-1beta in the male rat.

A number of recent studies have suggested that interleukin-1beta (IL-1beta) is a major mediator contributing to the recruitment of the hypothalamo-pituitary-adrenal (HPA) axis following infectious aggressions. Central catecholamines modulate the response of the HPA axis. To investigate the importance of the afferent catecholaminergic pathways in a pathophysiological situation, we used the intraperitoneal (i.p.) IL-1beta injection (mimicking peripheral infections) and we investigated the effects on the HPA responses to IL-1beta of bilateral neurotoxic (6-OHDA) deletion of the ventral noradrenergic ascending bundle (VNAB-X). The VNAB is an essential stimulating pathway linking the brainstem and the paraventricular nucleus (PVN). We determined the time courses of a number of HPA variables up to 240 min after i.p. injection of IL-1beta. We followed: plasma ACTH and corticosterone (CORT) concentrations, AP POMC nuclear primary RNA transcripts, AP POMC nuclear intermediate transcript RNA, AP POMC cytoplasmic mRNA, and hypothalamus (HT) CRH cytoplasmic mRNA. Compared to sham-lesioned male rats, VNAB-X animals displayed: (1) a reduced increase in plasma ACTH, and to a lesser extent in CORT throughout the experimental period with a 85% inhibition at the peak (90 min); (2) an increase in AP POMC primary nuclear transcript and in AP POMC nuclear intermediate transcript RNAs which last 60 min, instead of sustained significantly higher levels up to 240 min; (3) a similar, although reduced inhibition in the corresponding POMC cytoplasmic mRNA; (4) an almost complete abolishment of the marked biphasic rise in HT CRH mRNA. In conclusion, activation of the HPA axis by peritoneal IL-1beta challenge involves CRH-producing neurons, and afferent catecholaminergic innervation of the PVN plays a crucial role in the signaling machinery linking the peritoneal aggression to the HPA axis.
Hepatoprotective, Hypoglycemic, and Hypolipidemic Effect of Chokeberry Pomace on Polish Merino Lambs*

ABSTRACT To properly understand the biological effect of polyphenol compounds, it should not be assumed that they are generally bioavailable and are reaching tissues as expected. It is important to fully understand how polyphenol compounds are absorbed, metabolized, and finally eliminated from the organism. Most polyphenol compounds occur in the forms that cannot be absorbed in their primary form. Sheep make compounds bioavailable due to their unique digestive system properties. Despite this, several species of ruminants likely to serve as an experimental model were considered. However, due to the high costs for cattle and low popularity in the region of goats, sheep were selected as the experimental model. In the study, 24 Polish Merino lambs were randomly divided into a control and two experimental groups. The experimental groups were administered diets with the addition of 150 or 300 g of chokeberry pomace per each kg of complete feed mixture. Phenolics present in the chokeberry pomace were found to modulate biochemical blood parameters, resulting in hypoglycemic and hypolipidemic effects. Finally, the increase in total phenolics in the serum and liver of lambs induced a health-promoting effect on liver metabolic profile parameters.
Sleep Duration and Sleep Quality: Associations With Depressive Symptoms Across Adolescence

This study explored whether short sleep duration and sleep quality mediate the relationship between age and depressive symptoms. For comparison, we also explored whether depressive symptoms mediate the relationship between age and short sleep duration and sleep quality. The sample comprised 741 adolescents (63.5% female, mean age 15.78 years, range 11.92–19.67 years) in grades 7–12 from 11 secondary schools in metropolitan Melbourne, Australia. Students completed the Pittsburgh Sleep Quality Index (PSQI) and Center for Epidemiologic Studies Depression Scale (CES-D). Path analyses suggested that short sleep duration significantly mediated the relationship between age and depressive symptoms. Poor sleep quality also significantly mediated this relationship when sleep quality was defined by subjective judgement, but not sleep disturbance, sleep efficiency, or sleep onset latency. Depressive symptoms significantly mediated the relationship between age and short sleep duration and sleep quality (subjective judgement, sleep disturbance, sleep efficiency, and sleep onset latency). These findings suggest that the population-wide increase in depressive symptoms across adolescence is partially mediated by sleep-related developmental changes. They also highlight the importance of examining specific sleep problems when investigating the relationship between sleep and mood in this age group.
A Mendelian Randomization Study of the Effect of Type‐2 Diabetes and Glycemic Traits on Bone Mineral Density

Type‐2 diabetes (T2D) is associated in observational studies with both higher bone mineral density (BMD) and higher fracture risk for given BMD. These relationships may however be confounded by factors such as body mass index (BMI). Here we used Mendelian randomization (MR) to obtain non‐confounded estimates of the effect of T2D and glycemic traits on BMD. We identified genetic variants strongly associated with T2D risk (34,840 T2D cases and 114,981 controls) and fasting glucose (133,010 nondiabetic individuals), but not associated with BMI, and determined the effects of these variants on BMD (up to 83,894 individuals). Using these variants as instrumental variables, we found that a genetically‐increased risk of T2D increased femoral neck BMD (+0.034 SD in BMD per unit increase in log‐odds of T2D [95% CI, 0.001 to 0.067; p = 0.044]). Genetically‐increased fasting glucose also increased femoral neck BMD (+0.13 SD in BMD per mmol/L increase in fasting glucose [95% CI, 0.01 to 0.25; p = 0.034]). Similar nonsignificant trends were observed for the effects of T2D and fasting glucose on lumbar spine BMD. Our results indicate that both genetically‐increased T2D risk and genetically‐increased fasting glucose have weak positive effects on BMD. © 2016 American Society for Bone and Mineral Research.
Effects of Ovariectomy in an hSOD1-G93A Transgenic Mouse Model of Amyotrophic Lateral Sclerosis (ALS)

Background Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder characterized by progressive muscular dystrophy and paralysis; most ALS patients die from respiratory failure within 3 to 5 years, and there is currently no effective treatment. Some studies have indicated sex differences in the incidence of ALS, and evidence suggests a neuroprotective role for estrogen. Material/Methods We used human Cu/Zn superoxide dismutase (hSOD1-G93A) transgenic mice to determine the effects of ovariotomy on the onset of disease and behavior; we also used Western blotting to measure the expression of aromatase and estrogen receptors, as well as the inflammatory cytokines and apoptosis markers, in the lumbar spinal cord to determine the mechanism of estrogen-mediated neuroprotection. Results Ovariectomy advanced the onset of disease, down-regulated aromatase and estrogen receptor alpha (ER-α) expression, and inhibited expression of the anti-inflammatory factors arginase-1 and the anti-apoptotic factor B-cell lymphoma-2 (Bcl-2) in the lumbar spinal cord of hSOD1-G93A transgenic mice. Conclusions Ovariectomy resulted in earlier disease onset and attenuated the anti-inflammatory and anti-apoptotic actions of estrogen in hSOD1-G93A transgenic mice. Therefore, estrogen may play an important role in protecting spinal cord motor neurons.
Investigation of Extracts from Tunisian Ethnomedicinal Plants as Antioxidants, Cytotoxins, and Antimicrobials.

OBJECTIVE To determine the medicinal potential of various plants and their parts extracted with different solvents. METHODS The total phenolic content of acetonitrile/water (60%-40%) (ACN/W) and aqueous (W) extract fractions was determined by high-performance liquid chromatography (HPLC), and terpenic compounds were detected by gas chromatography/mass spectrometry (GC/MS). Antioxidant activity of the samples was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay and β-carotene bleaching method. Cell viability was investigated by thiazolyl blue tetrazolium bromide [3-(4,5-dimethylthiazol)-2-yl 2,5-diphenyltetrazolium bromide] (MTT) assay. The mechanisms involved in cytotoxic activity were investigated in a murine macrophage cell line (RAW 264.7) and cancer lines. RESULTS Our findings show that 11 plant species exhibited biological activity. In addition, moderate antibacterial activity was reported against one or more of the tested bacterial strains at two concentrations: 300 μg and 3 mg/disc. Furthermore, our data reveal that among all plants investigated, some extract and hydrophobic fractions were potent scavengers of the DPPH radical (6.78 μg/mL < EC50 < 8.55 μg/mL). Taken together, our results show that Nerium oleander (NOACN/W) and Pituranthos tortuosus (PTACN/W) were highly cytotoxic against RAW 264.7 cells with IC80 values of 0.36, and 1.55 μg/mL, respectively. In contrast, murine macrophage cell lines had low growth and were significantly sensitive to water extracts of Thymus hirtus sp. algeriensis (THW), Lavandula multifida (LMW), and ACN/W extract of Erica multiflora (EMACN/W) at doses > 400, 47.20, and 116.74 μg/mL, respectively. The current work demonstrates that RAW 264.7 cell proliferation was inhibited by samples in a dose-dependent manner. CONCLUSION Our findings, validated through free radical scavenging activity, agar diffusion assay, and cytotoxicity of essential oils towards cancer cells, show that ethnomedicinal plants used in this work have a novel application as a tumor suppressor.
Use of Language Sample Analysis by School-Based SLPs: Results of a Nationwide Survey.

PURPOSE This article examines use of language sample analysis (LSA) by school-based speech-language pathologists (SLPs), including characteristics of language samples, methods of transcription and analysis, barriers to LSA use, and factors affecting LSA use, such as American Speech-Language-Hearing Association certification, number of years' experience, and caseload characteristics. METHOD School-based SLPs responded to an invitation to complete an electronic survey related to LSA. RESULTS One third of respondents indicated they did not use LSA during the 2012-2013 school year. SLPs who served middle and high school students were less likely to use LSA. Most respondents reported using conversation to analyze fewer than 10 samples and transcribing in real time. Additional analyses revealed that SLPs who had 3 or fewer years of experience and who analyzed fewer than 20 language samples per year were statistically less likely to report using real-time transcription. The most frequently cited barrier to using LSA was "LSA is too time-consuming. " CONCLUSION Many school-based SLPs do not routinely use LSA. Further, many did not report engaging in evidence-based practices, such as recording samples, using established protocols, or using tasks designed to elicit complex syntax. These results indicate a continued need for professional development regarding evidenced-based practices relative to LSA use.
Instagram online shop's comment classification using statistical approach

Instagram is one of the currently popular social medias in Indonesia. Some online shop owners use Instagram to show their products and also use its comment section to communicate with their customers. A system that can classify Instagram comment automatically based on its response surely will help online shop owners to respond all various comments without having to read all of the comments. Thus, this study was conducted to find the best method to classify Instagram comment using statistical approach. In general, the system created in this study is divided into 4 components namely pre-process, feature extraction, feature selection, and classification. We compared several techniques in each component. In feature extraction, we compared lexical approaches (unigram) and word embedding approaches. As for the learning algorithm, we compared support vector machine (SVM) and convolutional neural network (CNN). The effect of pre-process and feature selection is also investigated in this study. The preprocess done in this study is basic pre-process, mention conversion, punctuation conversion, emoticon conversion, number conversion, formalization and region name conversion. The data used in this study is 2810 Instagram comments which have been labelled with 3 kinds of responses namely “answered”, “read”, and “ignored”. Using 10-fold cross validation, we conducted 3 experiment types, such as the baseline, pre-process, and word embedding. Baseline was done by using SVM as learning algorithm and unigram as feature. Pre-process experiment was done by adding pre-processing and feature selection to baseline. Word embedding experiment was done by using word embedding as feature and SVM or CNN as learning algorithm. The best result in this study was obtained from word embedding experiment using word embedding as feature representation, CNN as learning algorithm, and pre-processed model data with accuracy of 84.23%.