Miracle-dz/UniFAR-FTUs huggingface dataset:
Developing a Video-Based eHealth Intervention for HIV-Positive Gay, Bisexual, and Other Men Who Have Sex with Men: Study Protocol for a Randomized Controlled Trial

Background Gay, bisexual, and other men who have sex with men (GBMSM) accounted for 67% of new US human immunodeficiency virus (HIV) infections in 2012; however, less than 40% of HIV-positive GBMSM are virally suppressed. Preventing transmission from virally unsuppressed men who have condomless anal sex (CAS) with serodiscordant partners is a public health imperative. New HIV infections in GBMSM are attributed in part to online access to sex partners; therefore, low-cost eHealth interventions are a unique opportunity to reach men where they meet partners. Objective To describe the protocol of a randomized controlled trial evaluating whether video-based messaging delivered online may lead to reductions in serodiscordant CAS and increased HIV disclosure. Methods Sex Positive! [+] is a two-arm, phase III, video-based randomized controlled trial delivered online to GBMSM living with HIV. Participants in the intervention arm receive 10 video vignettes grounded in social learning and social cognitive theories that are designed to elicit critical thinking around issues of HIV transmission and disclosure. Participants in the attention control arm receive 10 video vignettes that focus on healthy living. All videos are optimized for mobile viewing. The study protocol includes five online assessments conducted over a 1-year period among 1500 US white, black, or Hispanic/Latino GBMSM living with HIV who report suboptimal antiretroviral therapy (ART) adherence or a detectable viral load in the past 12 months and recent CAS (past 6 months) with HIV-negative or unknown status male partners. Compared to the control arm, we hypothesize that men who watch the intervention videos will report at 12-month follow-up significantly fewer serodiscordant CAS partners, increased HIV disclosure, and improved social cognition (eg, condom use self-efficacy, perceived responsibility). Results Participant recruitment began in June 2015 and ended in December 2015. Conclusions This protocol describes the underlying theoretical framework and measures, study design, recruitment challenges, and antifraud measures for an online, video-based randomized controlled trial that has the potential to decrease HIV transmission risk behaviors among HIV-positive GBMSM who struggle with ART adherence. The Sex Positive! [+] intervention allows for participation through multiple Internet-based mediums and has the potential to reach and engage a broader population of HIV-positive GBMSM who are virally unsuppressed. ClinicalTrial ClinicalTrials.gov NCT02023580; https://clinicaltrials.gov/ct2/show/NCT02023580 (Archived by WebCite at http://www.webcitation.org/6iHzA8wRG)
How to obtain the confidence interval from a P value

Confidence intervals (CIs) are widely used in reporting statistical analyses of research data, and are usually considered to be more informative than P values from significance tests.1 2 Some published articles, however, report estimated effects and P values, but do not give CIs (a practice BMJ now strongly discourages). Here we show how to obtain the confidence interval when only the observed effect and the P value were reported. The method is outlined in the box below in which we have distinguished two cases. #### Steps to obtain the confidence interval (CI) for an estimate of effect from the P value and the estimate ( Est ) ##### (a) CI for a difference ##### (b) CI for a ratio
Total excision versus non‐resectional methods in the treatment of acute and chronic pilonidal disease

Data from all operations performed for pilonidal abscess and sinus were collected from medical records at this medical centre for the period 1980-1989. In all, 125 consecutive cases were reviewed. Complete follow-up was obtained from 100 patients. In 60 patients follow-up was completed in the surgical clinic, and time until healing was determined by a surgeon. In 40 patients follow-up was performed by telephone. Patients were asked when all symptoms ceased, specifically pain, discomfort and discharge from the wound. Cessation of symptoms was considered to be the point of healing. Follow-up ranged from 3 to 10 years, with a median of 6 years. The sex ratio (male :female) was 69 : 31. Mean (range) age was 25 (14-46) years. Wide local excision was performed with the wound packed open. To perform the Lord technique of excision and brushingz, Lord’s description was followed: the midline pits were excised, leaving only tiny midline wounds. The track was then stretched with tissue forceps, and a bottle brush with nylon bristles inserted and rotated to remove the hairs and debris. If considered necessary, lateral longitudinal wounds were used to achieve better drainage of the deep space.
Genomic Admixture Between Locally Adapted Populations of Arabidopsis thaliana (mouse ear cress): Evidence of Optimal Genetic Outcrossing Distance

Abstract Admixture can break up divergent genetic architectures between populations, resulting in phenotypic novelty and generating raw material for environmental selection. The contribution of admixture to progeny trait variation and fitness varies based on the degree of genetic isolation between the parental populations, for which most studies have used geographic distance as a proxy. A novel approach is to estimate optimal crossing distance using the adaptive genetic distance between mates estimated from loci that contribute directly to local adaptation. Here, we aim to understand the effect of admixture on disrupting local adaptation of ecotypes of Arabidopsis thaliana separated along gradients of geographic, background, and locally adaptive genetic distances. We created experimental F1 hybrids between ecotypes that vary in geographic distance and used SNP data to estimate background (putatively neutral) and adaptive genetic distance. Hybrids were grown under controlled conditions, and fitness, growth, and phenology traits were measured. The different traits measured showed a clear effect of adaptive genetic distance, but not geographic distance. The earliest bolting hybrids were intermediate in the adaptive genetic distance between their parents, and also had higher biomass and fitness in terms of fruit and seed production. Our results suggest that disruption of locally adaptive genomic loci decreases the performance of offspring between distantly related parents, but that crosses between very closely related parents also reduce performance, likely through the expression of deleterious recessive alleles. We conclude that during admixture, selection may have to balance the consequences of disrupting local adaption while also avoiding inbreeding depression.
Association of a functional CD19 polymorphism with susceptibility to systemic sclerosis.

OBJECTIVE CD19 is overexpressed in B cells from patients with systemic sclerosis (SSc), and plays a crucial role not only for autoantibody production, but also for skin fibrosis in mouse models. We previously reported the association of a GT repeat polymorphism in the 3'-untranslated region (3'-UTR) of CD19 with human systemic lupus erythematosus. In this study, we examined whether CD19 polymorphisms are associated with genetic susceptibility to SSc. METHODS A case-control association study was performed for CD19 polymorphisms, -499G>T in the promoter region and a GT repeat polymorphism in the 3'-UTR, in 134 patients with SSc and 96 healthy individuals recruited at Kanazawa University. CD19 expression levels in the peripheral blood naive and memory B cells from SSc patients were examined by 2-color flow cytometry. RESULTS Carrier frequencies of the -499T allele in the promoter (odds ratio [OR] 2.18, 95% confidence interval [95% CI] 1.31-3.86, P = 0.003) and of the (GT)(14) allele in the 3'-UTR (OR 1.86, 95% CI 1.05-3.28, P = 0.03) were significantly increased in SSc patients compared with healthy controls. Association was particularly evident in patients with limited cutaneous SSc with anticentromere antibodies. These alleles were in linkage disequilibrium, but the -499T allele seemed to play a primary role. CD19 expression levels in peripheral blood B cells were significantly elevated in both naive (P = 0.0029) and memory (P = 0.0022) B cells from patients with SSc who had the -499T allele as compared with those without the -499T allele. CONCLUSION The CD19 -499G>T polymorphism is associated with higher CD19 expression in B cells, and with susceptibility to SSc.
Genetic and metabolomic architecture of variation in diet restriction-mediated lifespan extension in Drosophila

In most organisms, dietary restriction (DR) increases lifespan. However, several studies have found that genotypes within the same species vary widely in how they respond to DR. To explore the mechanisms underlying this variation, we exposed 178 inbred Drosophila melanogaster lines to a DR or ad libitum (AL) diet, and measured a panel of 105 metabolites under both diets. Twenty four out of 105 metabolites were associated with the magnitude of the lifespan response. These included proteinogenic amino acids and metabolites involved in α-ketoglutarate (α-KG)/glutamine metabolism. We confirm the role of α-KG/glutamine synthesis pathways in the DR response through genetic manipulations. We used covariance network analysis to investigate diet-dependent interactions between metabolites, identifying the essential amino acids threonine and arginine as “hub” metabolites in the DR response. Finally, we employ a novel metabolic and genetic bipartite network analysis to reveal multiple genes that influence DR lifespan response, some of which have not previously been implicated in DR regulation. One of these is CCHa2R, a gene that encodes a neuropeptide receptor that influences satiety response and insulin signaling. Across the lines, variation in an intronic single nucleotide variant of CCHa2R correlated with variation in levels of five metabolites, all of which in turn were correlated with DR lifespan response. Inhibition of adult CCHa2R expression extended DR lifespan of flies, confirming the role of CCHa2R in lifespan response. These results provide support for the power of combined genomic and metabolomic analysis to identify key pathways underlying variation in this complex quantitative trait.
Las emociones y los valores del profesorado

El autor destaca que las emociones de los docentes son expresion de la interaccion con los alumnos y con los companeros, y que tambien dependen de las demandas y exigencias del sistema educativo. Si el trabajo de los profesores esta lleno de emociones y ocupan un papel determinante en la satisfaccion profesional de los docentes, es necesario preocuparse por su bienestar emocional y considerar el trabajo de los profesores como una profesion moral, que adquiere desde esta perspectiva toda su fuerza motivadora, porque el olvido o la falta de cuidado de esta dimension conduce a la �desmoralizacion� de los docentes, sobre todo cuando los modelos tradicionales estan enfrentados.
External Auditor Selection Choice: A Multinomial Logistic Regression Approach

This research work examines the factors that determine the selection of external auditor among Global Brand listed companies in Nigeria. The variables of Audit Big 4 firms which include Deloitte, Klynveld Peat Marwick Goerdeler, (KPMG) and Price Water House Coopers (PWC) where selected as choice target for this research work. Big four audit firm of Ernst’s & Young (E&Y) was excluded in the sample as it is found not to have provided audit services to any of the selected global brand listed company in Nigeria during the period covered by this study. The study employed the methodology of Multinomial Probit Regression (MPR) analysis in X-raying the data. Empirical evidence shows that there is a significant positive relationship between firm size and choice of external auditor’s selection for the big four audit firms of KPMG and Deloitte. The study also provides a revelation that the relationship between the variable of firm size is negative and statistically significant with audit firm of Price Water House Coopers (PWC). The research work carefully recommends that global brand companies in Nigeria with interest to hire audit services of Deloitte and KPMG must ensure that its total asset is significantly large. But suffice to state here that this may not apply to the audit firm of Price Water House Copper Corporation where the variable of audit fee is a significant determinant in the quest for employing it audit services.
Prospects of Plant-Based Trimethylolpropane Esters in the Biolubricant Formulation for Various Applications: A Review

Biodegradable lubricants from renewable feedstocks have been successfully developed to meet the demands of new machines with stringent requirements of the global standards, which address sustainability and environmental policy. Trimethylolpropane ester (TMPE) has been extensively evaluated as a biolubricant base stock and occasionally used as an additive, due to their low toxicity and excellent biodegradability. The formulation of high-performance TMPE-based lubricants involves addition of surface additives, multifunctional additives, and solid nano particles. This review focuses on the development of plant-based TMPE formulation for various applications, namely food-grade lubricant, engine oil, drilling fluid, insulating fluid, metal working fluid, hydraulic and heat transfer fluids. Even though plant-based TMPE lubricants have huge advantages over mineral oils, they have other challenging issues such as limited load-bearing capacity, hygroscopic properties, and high risk of toxic emission owing to additives selection. The details on the performance characteristics of TMPE as base stocks and additives are discussed, including the current prospects and challenges in the respective areas. This review concludes with a brief discussion on suggestions and recommendations for future advancement in the usage of TMPE and the remaining issues that must be overcome to allow for its full potential to be realized.
Effect of mild dehydration on the lactate threshold in women.

PURPOSE The purpose of this investigation was to examine the effects of dehydration on the lactate threshold and performance time to exhaustion in women. METHODS Seven moderately trained women (age = 23.6 +/- 1.6 yr) performed two graded exercise tests on separate occasions, once in a normally hydrated state (HY) and once in a dehydrated state (DE). Dehydration was achieved by a 45-min submaximal exercise the evening before testing, followed by a 12-h period of fluid restriction. VO2, VCO2, V(E), R-values, blood lactate, and catecholamine concentrations were measured at baseline and during each workload. Plasma volume and plasma osmolality were also determined. Body weight dropped significantly for the dehydrated trial (2.6 +/- 0.7%). RESULTS There was a corresponding decrease in plasma volume measured (3.5 +/- 2.6%). The VO2max (3.1 +/- 0.3 L x min(-1) HY; 3.0 +/- 0.1 L x min(-1) DE) obtained was not significantly different between the hydration and dehydration trial. Plasma norepinephrine, epinephrine, and lactate concentrations were not significantly different at baseline or maximum intensity although epinephrine concentrations were higher for the dehydrated trial during submaximal workloads. Lactate concentrations were highly correlated with epinephrine (r = 0.95 HY; r = 0.97 DE). The lactate threshold occurred at a significantly lower relative percent of VO2max for the dehydrated trial (72.2 +/- 1.1% HY; 65.5 +/- 1.8% DE) as well as a lower absolute power output when compared with that in the hydrated trial. There was a significant decrease in time to exhaustion for the dehydrated trial (17.3 +/- 0.7 min HY; 16.3 + 0.7 min DE). Time to exhaustion for the dehydrated trial was correlated with the % VOmax at which the lactate threshold occurred (r = 0.74). CONCLUSIONS These data indicate that low levels of dehydration induced a shift in the lactate threshold, in part because of elevated epinephrine concentrations. This shift may have been one cause for the decrease in time to exhaustion for the dehydrated trial.
Pengaruh sikap keuangan, pengetahuan keuangan dan pengalaman keuangan terhadap perilaku pengelolaan keuangan keluarga di sidoarjo

Behavior of financial management has become a very important issue at this time. This is related to the behavior of the consumerist society in Indonesia, and included in Sidoarjo. Indonesia society is still not saving to the maximum. The public tend to think short-term and is identical to the implusif shopping practices so often with sufficient revenue they are still having problems because the financial behavioral finance that is less accountable. Based on the feneomena, this research aims to know the influence of financial attitudes, knowledge, and experience of finance finances financial management behavior against family in Sidoarjo with data analysis technique used is MRA. Respondents who made the sample amounted to 150 people by the criteria of the respondent are domiciled in Sidoarjo, a financial manager, and have an income of at least Rp 3.5 million per month. Based on the research results, financial attitude of influential positive significant to financial management. While the financial knowledge and financial experience the positive effect is not significant to financial management behavior. Key Words : Financial Attitude, Financial Knowledge, Financial Experience, Financial Management Behavior.
The The Influence of Audit Tenure and Audit Committee on Earnings Quality

One of the Auditor and Audit committee role is to ensure the quality of corporate financial reporting process. This study aims to test the effect of the length of auditor tenure and audit committee on earning quality measured by the absolute value of discretionary accruals. A sample of 465 companies has been selected and data covering the period 2009-2014 has been collected from these firms, where 2325 observation were used in this analysis. The data collected form CSMAR and analyzed using GLS regression analysis. This study found that the short audit tenure on Chinese listed company in Shenzhen Stock Exchange has a significance negative influence on earning quality, meanwhile this study found that audit committee which is measure by the size of the committee does not has a significance influence on earning quality. This study suggests that auditor should have a longer tenure to gain adequate knowledge of client’s business. Moreover companies should strengthen the role of their audit committee in monitoring financial reporting process by improved their activity and financial knowledge of the member.
Yeasts from the microbiota of bats: a focus on the identification and antimicrobial susceptibility of cryptic species of Candida.

Bats harbour several pathogens that can be disseminated through their faeces, hence becoming important sources of environmental contamination once they are able to fly long distances (Botelho et al., 2012). Yeasts colonize the gastrointestinal tract of different animal species (Brilhante et al., 2013), but reports on the composition and antifungal susceptibility of the yeast microbiota of bats are scarce. Therefore, this study aimed at isolating yeasts from bats and their droppings, investigating the occurrence of the cryptic species Candida albicans–Candida dubliniensis, Candida parapsilosis complex, Candida famata complex and Candida guilliermondii complex and assessing the antifungal susceptibility of the recovered isolates. This project was approved by the Chico Mendes Institute of Biodiversity (licence 45268-1) and the Ethics Committee for the Use of Animals of the State University of Cear a (protocol 4797909/2014). Animals were captured in Fortaleza and Metropolitan Region, state of Cear a, Brazil, from January to April 2015, with mist or dip nets. Bat species were identified according to Reis et al. (2007).
Dentinogênese imperfeita: abordagem clínica e relato de caso na dentição decídua

A dentinogenese imperfeita e uma anomalia do tecido dentinario de carater hereditario que afeta ambas as denticoes deciduas em individuos de uma mesma familia, discutindo os principais aspectos desta patologia bem como sua abordagem clinica.
Polyomavirus Large T Antigen Binds the Transcriptional Coactivator Protein p300

ABSTRACT Using coimmunoprecipitation and glutathioneS-transferase pulldown experiments, we found that polyomavirus large T antigen binds to p300 in vivo and in vitro. The N-terminal region of the viral protein, including the pRB binding motif, was dispensable for this interaction, which involved several regions within the C-terminal half of the large T antigen. Interestingly, anti-T antibody coimmunoprecipitated a subspecies of p300 which has high histone acetyltransferase activity.
Discriminating between different modes of inheritance in genetic disease

A genetics program library (Morton 1969a) was used to study the problem of discrimination between different modes of inheritance in genetic disease. Data were generated on familial frequencies and on the distribution of affected sibships by a two‐allele single‐locus model and the goodness of fit was tested hy a multifactorial model to the data and vice versa.
Degarelix for prostate cancer

The growth of prostate cancer cells is hormone dependent in the majority of patients with the disease. Lowering testosterone either surgically or medically (usually with a gonadotropin releasing hormone (GnRH) agonist) is the standard of care in patients with metastatic prostate cancer. Degarelix is a new GnRH antagonist for the treatment of patients with prostate cancer. In contrast to GnRH agonists, the development of GnRH antagonists was hindered for a long time owing to histamine-releasing activity and lack of potency and water solubility. Recently, however, degarelix has been approved by the FDA for the treatment of advanced prostate cancer. This review summarizes the preclinical and clinical data available for degarelix and describes its potential role in the market of prostate cancer therapeutics.
Maternal concerns about immunization over 0–24 month children: a qualitative research

The purpose of this qualitative study was to determine the concerns of mothers referred to health center in south Tehran, Iran about immunizing children aged 0–24 months. Data were collected using individual semi-structured interviews and analyzed using content analysis. The mothers’ concerns over immunizing their children fell into 5 main categories: (1) “Factors that cause mothers’ concerns,” (2) “Factors that influence mothers’ concerns,” (3) “Information, education, and communication barriers,” (4) “Informational/educational needs and sources,” and (5) “The necessity of childhood vaccinations. ” According to study findings, mothers consider immunizing children important and they have enough trust in the health system. A deep understanding of maternal concerns about immunizing their children at 0–24 months allows nurses to reduce mothers’ concerns by removing communication barriers and providing appropriate and adequate information.