Miracle-dz/UniFAR-FTUs huggingface dataset:
Insurance Coverage and Health Care Consumers' Use of Emergency Departments

Abstract How successful has managed care been in controlling costs and consumers' inappropriate use of health care services? This study compares national data from 1992 and 1996 to determine the effect of managed care on appropriateness of ED utilization. ED utilization was described in two ways as defined in Gooding, Smith, and Peyrot (1996): (1) urgency of visit (urgent vs. non-urgent), and (2) appropriateness of visit taking into account the care provided upon visits (including treatment and diagnostic procedures) and disposition of visit (admit, transfer, and discharge against medical advice). Potentially appropriate visits were the non-urgent cases at which treatment procedures and/or non-routine diagnostic procedures were performed. All urgent visits were defined as appropriate. Study results reveal that consumers' ED misuse changed in complex ways over the period examined. Contrary to our assumptions based on earlier research, the pattern of change was not the same for the two different measures of misuse. Non-urgent use decreased, as hypothesized, but there was an increase in non-urgent use which we have defined as inappropriate (i.e., no treatment and no non-routine diagnostic tests). ED misuse did not decrease more for insured than uninsured consumers, nor more for managed care than fee-for-service consumers. These findings bring into question the efficacy of efforts to address rising health care costs through controlling consumer utilization of services via managed care, efforts mirrored by many fee-for-service indemnity plans. Future research is needed to determine why this consumer misuse of the ED appears to continue and how the recent increase in the marketing of ED services may exacerbate this problem.
Recent advances in plant hepatoprotectives: A chemical and biological profile of some important leads

Medicinal plants have been traditionally used for treating liver diseases since centuries. Several leads from plant sources have been found as potential hepatoprotective agents with diverse chemical structures. Although, a big list of hepatoprotective phytomolecules was reported in the scientific literature, only a few were potent against various types of liver damages. Of which, silymarin, andrographolide, neoandrographolide, curcumin, picroside, kutkoside, phyllanthin, hypophyllanthin, and glycyrrhizin have largely attracted the scientific community. This review focuses discussion on the chemistry, biological activity, mode of action, toxicity, and future prospects of these leads. © 2007 Wiley Periodicals, Inc. Med Res Rev, 28, No. 5, 746–772, 2008
Data-Based Meridional Overturning Streamfunctions for the Global Ocean

Abstract The meridional overturning circulation for the Atlantic, Pacific, and Indian Oceans is computed from absolute geostrophic velocity estimates based on hydrographic data and from climatological Ekman transports. The Atlantic overturn includes the expected North Atlantic Deep Water formation (including Labrador Sea Water and Nordic Sea Overflow Water), with an amplitude of about 18 Sv through most of the Atlantic and an error of the order of 3–5 Sv (1 Sv ≡ 106 m3 s−1). The Lower Circumpolar Deep Water (Antarctic Bottom Water) flows north with about 8 Sv of upwelling and a southward return in the South Atlantic, and 6 Sv extending to and upwelling in the North Atlantic. The northward flow of 8 Sv in the upper layer in the Atlantic (sea surface through the Antarctic Intermediate Water) is transformed to lower density in the Tropics before losing buoyancy in the Gulf Stream and North Atlantic Current. The Pacific overturning streamfunction includes 10 Sv of Lower Circumpolar Deep Water flowing north in.
Molecular Characterization of Potential Microcystin-Producing Cyanobacteria in Lake Ontario Embayments and Nearshore Waters

ABSTRACT The distribution and genotypic variation of potential microcystin (MC) producers along the southern and eastern shores of Lake Ontario in 2001 and 2003 were examined using a suite of PCR primers. Cyanobacterial, Microcystis sp. , and Microcystis-specific toxin primer sets identified shoreline distribution of cyanobacterial DNA (in 97% of the stations) and MC synthetase genes (in 50% of the stations). Sequence analysis of a partial mcyA amplicon targeting Microcystis, Anabaena, and Planktothrix species indicated that the Microcystis sp. genotype was the dominant MC genotype present and revealed a novel Microcystis-like sequence containing a 6-bp insert. Analysis of the same samples with genus-specific mcyE primers confirmed that the Microcystis sp. genotype was the dominant potential MC producer. Genotype compositions within embayments were relatively homogenous compared to those for shoreline and tributary samples. MC concentrations along the shoreline exhibited both temporal and spatial differences as evidenced by the protein phosphatase inhibition assay, at times exceeding the World Health Organization guideline value for drinking water of 1.0 μg MC-LReq liter−1. MC genotypes are widespread along the New York State shoreline of Lake Ontario, appear to originate nearshore, and can be carried through the lake via wind and surface water current patterns.
An Eye-tracking Study of Named Entity Annotation

Utilising effective features in machine learning-based natural language processing (NLP) is crucial in achieving good performance for a given NLP task. The paper describes a pilot study on the analysis of eye-tracking data during named entity (NE) annotation, aiming at obtaining insights into effective features for the NE recognition task. The eye gaze data were collected from 10 annotators and analysed regarding working time and fixation distribution. The results of the preliminary qualitative analysis showed that human annotators tend to look at broader contexts around the target NE than recent state-of-the-art automatic NE recognition systems and to use predicate argument relations to identify the NE categories.
Conserved anterior boundaries of Hox gene expression in the central nervous system of the leech Helobdella.

Molecular developmental studies of fly and mouse embryos have shown that the identity of individual body segments is controlled by a suite of homeobox-containing genes called the Hox cluster. To examine the conservation of this patterning mechanism in other segmented phyla, we here describe four Hox gene homologs isolated from glossiphoniid leeches of the genus Helobdella. Based on sequence similarity and phylogenetic analysis, the leech genes Lox7, Lox6, Lox20, and Lox5 are deemed to be orthologs of the Drosophila genes lab, Dfd, Scr, and Antp, respectively. Sequence similarities between Lox5 and Antp outside the homeodomain and phylogenetic reconstructions suggest that the Antennapedia family of Hox genes (as defined by Bürglin, 1994) had already expanded to include at least two discrete Antp and Ubx/abdA precursors prior to the annelid/arthropod divergence. In situ hybridization reveals that the four Lox genes described in this study are all expressed at high levels within the segmented portion of the central nervous system (CNS), with variable levels of expression in the segmental mesoderm. Little or no expression was seen in peripheral ectoderm or endoderm, or in the unsegmented head region (prostomium). Each Lox gene has a distinct anterior expression boundary within one of the four rostral segments, and the anterior-posterior (AP) order of these expression boundaries is identical to that reported for the orthologous Hox gene products in fly and mouse. This finding supports the idea that the process of AP axis differentiation is conserved among the higher metazoan phyla with respect to the regional expression of individual Hox genes along that axis. One unusual feature of leech Hox genes is the observation that some genes are only expressed during later development -- beginning at the time of terminal cell differentiation -- whereas others begin expression at a much earlier stage, and their RNA ceases to be detectable shortly after the onset of expression of the 'late' Hox genes. The functional significance of this temporal disparity is unknown, but it is noteworthy that only the two 'early' Hox genes display high levels of mesodermal expression.
EVIDENCE THAT IMIDAZOL(ID)INE‐ AND SULPHONYLUREA‐BASED ANTAGONISTS OF CROMAKALIM ACT AT DIFFERENT SITES IN THE RAT THORACIC AORTA

1. Ring segments of rat thoracic aorta were suspended in organ baths to record isometric tension. Tissues were precontracted with K+ (20 mmol/ L), and full concentration—relaxation curves constructed to cromakalim (0,01–30 μmol/L) in the absence and presence of increasing concentrations of glibenclamide, glipizide, tolbutamide (the sulphonylureas), alinidine (an imidazolidine), phentolamine (an imidazoline), and chlorpromazine (the phenothiazine derivative). Whereas the active sulphonylureas, glibenclamide and glipizide, displayed classical competitive antagonism, the remaining compounds (alinidine, phentolamine and chlorpromazine) caused shifts in the cromakalim concentration—effect curves associated with a reduction in the slope and maximum response.
Geyser model with real-time data collection

The physical model of geyser oscillations presents a challenge to experts, even under controlled conditions met in a laboratory experiment. Despite complex dynamics some qualitative analysis can be made on an introductory physics level using observations and real-time data measurements. By varying the system parameters, one can achieve different behaviour from the hot spring to the geyser-like. We present a laboratory experiment of geyser eruptions and its analysis with real-time temperature and pressure monitoring combined with video recording. The presented geyser model proved to be useful as a student project that offers several new open-ended problems.
Factors influencing malnutrition among young children in a rural community of Sarawak

Introduction: This study aimed to determine the prevalence of malnutrition and factors influencing malnutrition among children aged five years and below in Serian District of Sarawak, a district where the majority of people are indigenous. Methods: Using a cross-sectional method, a total of 177 children were randomly selected and assessed, and their mothers or caregivers were interviewed. Data were collected using a pretested questionnaire; anthropometric measurements were also taken. Data were analysed using SPSS version 17.0. Results: The prevalence of underweight, stunting and wasting in children aged five years and below was 20.9%, 11.9% and 10.2% respectively. The results suggest that the significant factors contributing to underweight are birth weight, frequency of child visit to the clinic, and individual insecurity. Only age, when complementary diet was introduced, was found to be significantly associated with stunting. For wasting, individual insecurity, duration of family planning and met recommended protein intake per day were found to be significant factors. Conclusion: The prevalence of malnutrition in children 5 years and below in Serian District of Sarawak is high compared to state figures. The major contributing factors were found to be manifested at the individual and family level. There is a need for appropriate public health promotion and socioeconomic improvement interventions towards improving the nutritional status and health of children in Serian District.
Associations between glucosamine and chondroitin supplement use and biomarkers of systemic inflammation.

OBJECTIVES Glucosamine and chondroitin supplements have been shown to have anti-inflammatory properties in both in vitro studies and animal models; however, little is known about these relationships in humans. The VITamins and Lifestyle (VITAL) biomarker study evaluated the associations between use of these supplements and a panel of circulating inflammatory biomarkers. DESIGN Study participants included 217 men and women age 50-75 years living in the Seattle metropolitan area. Use of glucosamine and chondroitin supplements was ascertained by home interview/supplement inventory. Inflammation was assessed by using blood and urine collected at the time of home interview. Measures of systemic inflammation included plasma high-sensitivity C-reactive protein (hsCRP), interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor (TNF)-α, soluble TNF receptors I and II, and urinary prostaglandin E2-metabolite (PGE-M). Multivariate-adjusted linear regression was used to evaluate the associations between supplement use and biomarkers of inflammation. RESULTS High users (14 or more pills/week) of chondroitin had 36% lower hsCRP (ratio, 0.64; 95% confidence interval [CI], 0.39-1.04; p for trend=.03) and 27% lower PGE-M (ratio, 0.73; 95% CI, 0.5-0.98; p for trend=.07) than nonusers. Compared with nonusers, high users of glucosamine had 28% lower hsCRP (ratio, 0.72; 95% CI, 0.47-1.08; p for trend=.09) and 24% lower PGE-M (ratio, 0.76; 95% CI, 0.59-0.97; p for trend=0.10). Use of glucosamine and chondroitin supplements was not associated with the other markers of inflammation. CONCLUSIONS These results support prior research suggesting that use of glucosamine and chondroitin is associated with reduced hsCRP and PGE2, but further work is needed to more definitively evaluate the anti-inflammatory potential of these supplements.
One century of vegetation change on Isla Persa, a nunatak in the Bernina massif in the Swiss Alps

Abstract Question: How did the vascular plant species composition of a nunatak in the alpine vegetation belt change over a time span of 100 years? Location: A 5.6-ha nunatak, Isla Persa in the Swiss Alps, that remained ice-free during the last maximum glacier advance in the 1850s and is today partly covered with climactic alpine grassland and dwarf heath shrubs. Methods: Floristic inventories in 1906, 1927, 1972, 1995, 2003 and 2004 and a comparative analysis of the species composition over the period 1906–2004. Results: 31 species that were not recorded in the first inventory were found in the following surveys. However, among them only six were common by 2004. Generally, the new species prefer warmer conditions than those previously present and most newcomers are associated with montane or sub-alpine grasslands and woodlands. In particular, the observed increase of Vaccinium myrtillus and the arrival of shrub and tree species further substantiate a trend towards vegetation composition of the lower altitudinal belt. Ferns represented 26% of the newcomers, probably due to the high dispersal ability of their lightweight spores. The observed species enrichment was globally small compared to previously inventoried summits. Conclusion: Floristic change strongly suggests warmer climatic conditions as the main factor contributing to species compositional change. The relative stability of species richness may be explained by several factors: the isolation of the nunatak and the difficulties for plants to reach the site, the colder local climate, a limited available species pool and interactions of established alpine plants with newly immigrating taxa. Supplementary data collected at a similar altitude would be necessary to better understand the influence of climate change on alpine grasslands. Nomenclature: Aeschimann et al. (2004).
Biological and environmental correlates of developmental outcome of prematurely born infants in early adolescence.

Examined the role of biological factors (birth weight and perinatal medical complications) and psychosocial factors (maternal attitudes, paternal involvement, mother's personal state, marital adjustment, family relations, and socioeconomic status) in predicting long-term outcome of 90 Israeli adolescents born prematurely at very low birth weight (VLBW). As compared with 90 adolescents born full-term at normal birth weight (NBW), the VLBW children scored lower on all measures except reading comprehension. IQ, visual-motor coordination, and hyperactive behavior were predicted by both biological and psychosocial variables, visual memory by biological variables, and reading comprehension by psychosocial variables. The findings support chiefly the main effects model of developmental psychopathology (i.e., biological and psychosocial variables are additive in predicting outcomes), but also the interactional model (e.g., SES was influential in predicting visual-motor coordination and hyperactive behavior in the VLBW group but not in the NBW group).
Autocratic Elections: Stabilizing Tool or Force for Change?

Do elections reduce or increase the risk of autocratic regime breakdown? This article addresses this contested question by distinguishing between election events and the institution of elections. The authors propose that elections stabilize autocracies in the long term but at the price of short-term instability. Elections are conducive to regime survival in the long run because they improve capacities for co-optation and repression but produce short-term instability because they serve as focal points for regime opposition. Drawing on data from 259 autocracies from 1946 to 2008, the authors show that elections increase the short-term probability of regime failure. The estimated effect is retained when accounting for the endogeneity of autocratic elections; this finding is critical, since some autocrats may or may not hold elections because of perceived effects on regime survival. The authors also find that this destabilizing effect does not operate in the long term. They find some, although not as strong, evidence that elections stabilize autocratic regimes in the medium to long term, despite their destabilizing immediate effects. These temporal effect patterns are present for both executive and legislative elections, and they are robust to using different measures, control variable strategies, and estimation techniques. In line with expectations, both effect patterns are much clearer for multiparty autocratic elections than for completely uncontested elections.
Changes in antipsychotics and other psychotropic drugs during a 30-month lifestyle intervention among outpatients with schizophrenia

Abstract Background: Patients with schizophrenia have high risk of early death from diabetes and cardiovascular diseases, partly because of poor lifestyle and partly because of long-lasting exposure to antipsychotic treatment. Aims: To investigate the influence of a lifestyle intervention program on changes in psychotropic medication in a non-selected cohort of patients with schizophrenia. Methods: Observational study of outpatients in the Central Denmark Region during a 30-month lifestyle program. Results: One hundred and thirty-six patients were enrolled and 130 were available for analysis. Median follow-up time was 15.9 months (range 1–31 months). Nineteen patients (15%) were not treated with antipsychotic drugs during the study period. 54% of the 111 patients exposed to antipsychotics were subject to monotherapy at index and at follow-up. The median defined daily dose (DDD) of antipsychotics was 1.33 at index (interquartile range (IQR) 0.67–2.00) and 1.07 at follow-up (IQR 0.40–1.50). 52% of the patients experienced a decrease in DDD during the study period (median change 0.33; IQR 1.00–0.43). There were no significant differences between the patients with decreased, stable or increased DDD with regard to age, sex, follow-up time and time since diagnosis. The number of prescriptions was significantly higher in the patients who decreased their DDD and the proportion of antipsychotic depot formulation was higher in those who increased their DDD. Conclusions: Most patients decreased or stabilized their total dose of antipsychotic medication during the study period. Many patients were subject to antipsychotic polypharmacy. The extent of participation in the lifestyle intervention program did not correlate with the changes in dosing of antipsychotic medication.
Embedded systems for prototyping underwater acoustic networks: The DESERT Underwater libraries on board the PandaBoard and NetDCU

In this paper, we consider underwater network prototyping using the network simulation engine NS-Miracle, and investigate different embedded computer boards that can be employed for this task. In particular, we consider two embedded platforms with considerably different capabilities: the PandaBoard (a powerful platform that does not require any cross-compilation effort) and version 5.2 of the NetDCU board, which is much more constrained in terms of computational power, RAM and storage space. After describing the steps required to install NS-Miracle and the DESERT Underwater libraries on board these platforms, we report on the field experiments conducted to test the corresponding prototypes. Our results include a comparison between the two investigated platforms in terms of resources required (e.g., memory occupancy and energy expenditure) and performance in the execution of real-time software (e.g., delays introduced within the simulation framework). We believe that our work represents an interesting step towards the realization of underwater network prototypes made of heterogeneous nodes.
Assessment of knowledge, attitude and practice among diabetic patients attending a health care facility in North India

Background: Diabetes mellitus (DM) is a chronic disease that occurs either when the pancreas does not produce enough insulin or when the body cannot effectively use the insulin it produces. It is an important risk factor for blindness, vascular disease, brain diseases renal failure, and limb amputations. DM is increasing in developing countries due to unhealthy lifestyle, rapid westernization, and poor knowledge and practice of disease. Objectives: To study the knowledge, attitude and practice of diabetic patients attending Urban Health and Training Centre (UHTC). Methodology: An Out Patients Department based, descriptive, observational study was carried out among adult diabetic patients attending UHTC. Detailed history and physical examination was done. Level of knowledge, attitude and practice towards diabetes mellitus was assessed. Results: Total 124 Diabetes mellitus Type 2 patients were included in the study. 62.13% were males and 37.9% were females. Majority of patients (52.4%) were in the age group of 50 – 59 years. 22.6% were illiterate. 16.1% of patients were unemployed or unskilled workers. 34.7% were from middle socio economic class. 75 (60.5%), 88 (71.0%), and 98 (79.0%) had poor score of knowledge, attitude and practice of diabetes respectively. Conclusion: Adequate knowledge, positive attitude and good practices are important for effective control of diabetes mellitus. Patients require continuous support from family members to bring about a change in lifestyle. Also, people have to be educated through mass media on diabetes mellitus and its risk factors for its effective control in the community.