Miracle-dz/UniFAR-FTUs huggingface dataset:
TGF-β signalling-related markers in cancer patients with bone metastasis

Abstract We measured transforming growth factor (TGF)-β-dependent biomarkers in plasma and in peripheral blood mononuclear cells (PBMCs) to identify suitable pharmacodynamic markers for future clinical trials with TGF-β inhibitors. Forty-nine patients with bone metastasis were enrolled in the study, including patients with breast (n=23) and prostate cancer (n=15). Plasma TGF-β1 levels were elevated in more than half of the cancer patients (geometric mean 2.63 ng ml−1) and positively correlated with increased platelet factor 4 (PF4) levels, parathyroid-related protein (PTHrP), von Willebrand Factor (vWF) and interleukin (IL)-10. PBMC were stimulated ex vivo to determine the individual biological variability of an ex vivo assay measuring pSMAD expression. This assay performed sufficiently well to allow its future use in a clinical trial of a TGF-β inhibitor.
Determinants of Responses to Oral Vaccines in Developing Countries

Oral vaccines which are intended for global use do not necessarily induce the same immune responses in all children worldwide. In fact, several vaccines often induce less frequent and lower mean antibody responses in children in developing countries, suggesting that the vaccines may be less protective among children in these areas. Though the reasons for this less vigorous response are not completely understood, it appears that nutrition-related factors, including both protein-calorie and micronutrient malnutrition, are important aspects in understanding the hyporesponsiveness seen in these children. Related issues including breastfeeding, interference from maternal placental antibodies, intestinal parasitic infections, intestinal mucosal damage and possibly maternal malnutrition during pregnancy also appear to be important. Vaccines designed for oral administration will need to be adjusted to these potential problems in order to maximize benefits for all children. Oral vaccines, when given to children in developing countries, may require higher doses of vaccine, booster doses, calorie, micronutrient and vitamin supplements, withdrawal of breast milk before vaccine administration, deworming medications or other measures to realize their full benefit.
KANSEI analysis of dance performance

We propose a method to realize extractions of emotional information from human gestures in real time. The basic ideas of understanding the human motion is based on Rudolf Laban's theoretical work. The system we developed consists of two parts: image processing; and motion analysis. The former part works to obtain human movement by using two color CCD cameras, while the latter is involved in mapping physical parameters onto emotional information. We are trying to realize a sort of "KANSEI extractor" as the last goal. Humans can understand the emotional mode, such as happy, angry and sad, in which mode the actor performs. It seems that human movement carries emotional information although it is difficult to express the emotional effects with particular physical parameters. From this point of view, we aim to extract emotional information in dance performance with the aid of a computer system based on Laban's theory of movement. In our proposed method, human motions are mapped onto low-dimensional parameter space in real time introducing two spaces: the general space- and personal space.
Incidence of Adverse Drug Reactions in Patients on Antiretroviral Therapy: A study of Pharmaceutical Care in HIV Interventions in Nigeria

Background: Over 415,000 HIV-infected patients are receiving antiretroviral therapy (ART) in Nigeria butstudies documenting their adverse reactions are limited. Objectives: This study determined the incidence and type of ADRs of severity grades II to IV in ART patientsfollowing pharmaceutical care directed active ADR surveillance program in Nigeria. Methods: This was a longitudinal study. A study-specific pharmaceutical care daily worksheet and nationalADR reporting form were used for ADR screening and reporting respectively. Study population included73,589 ART patients who were screened for ADR from April 2009 to December 2010 in 69 HIV treatmentcentres. All individual case safety reports (ICSRs) of severity grades II to IV in these patients were collated andanalyzed. Chi-square was used to test the association between groups of variables at 95% ConfidenceInterval. Results: A total of 4600 ICSRs of severity grades II to IV reported were analyzed. Mean age of patients was 35.5(95%CI, 35.2-35.9) years; 68.1% were females; and 7002 ADRs were reported, an average of 1.5 ADR perpatient. ADR incidences were 18.2% for d4T/3TC/EFV, 13.9% for d4T/3TC/NVP, and 4.4% for AZT/3TC/NVPregimens; however overall incidence was 6.3%. Major reported ADRs included skin rash (16.5%); peripheralneuropathy (12.7%); and headache (9.4%). ADR occurrence was associated with specific ART regimens,concomitant medicines and age groups (p<0.05), unlike gender. Lipodystrophy was associated withd4T/3TC/NVP [OR=3.9 (95%CI: 2.2-6.7), p=0.0000] and d4T/3TC/EFV [OR=2.9 (95%CI: 1.1-7.2), p=0.0095]regimens compared with other regimens. Conclusion: There was low incidence of ADRs of severity grades II to IV which was higher in patients whoreceived d4T-based regimen compared to other regimens. Key words: HIV, ART, ADR Active Surveillance, Pharmaceutical Care, Nigeria.
Pengaruh Idealisme, Relativisme dan Materialisme terhadap Pandangan akanPeran Etika dan Tanggung Jawab Sosial Perusahaan (TJSP)

Seiring dengan perkembangan zaman, wacana mengenai peran etika dan tanggung jawab sosial perusahaan semakin marak diperbincangkan oleh para pelaku bisnis, organisasi maupun bidang penelitian dan pendidikan. Etika dan tanggung jawab sosial perusahaan (TJSP) ini diterapkan sehari-hari oleh para karyawan atau sumber daya manusia (SDM) perusahaan. Dengan demikian, penting untuk mengetahui pandangan dari calon-calon SDM, termasuk di dalamnya para mahasiswa. Mengingat bahwa para mahasiswa tersebut adalah calon manajer ataupun calon-calon pemimpin perusahaan di masa yang akan datang dan dipandang sebagai kaum terpelajar, maka pandangan mereka terhadap peran etika dan TJSP memiliki peran penting sebelum nantinya terlibat langsung dalam pelaksanaan. Adapun tujuan dari penelitian ini adalah untuk menganalisis pengaruh dari idealisme, relativisme, dan materialisme terhadap pandangan akan peran etika dan TJSP. Penelitian ini dilakukan dengan menyebarkan kuesioner kepada para mahasiswa bisnis (Akuntansi dan Manajemen) di Universitas Atma Jaya Yogyakarta. Selanjutnya dengan kombinasi teknik convenience sampling dan purposive sampling, kriteria sampel yang ditentukan adalah mahasiswa yang telah mengambil matakuliah etika bisnis. Adapun variabel independen sebagai variabel prediksi dalam penelitian ini adalah idealisme, relativisme, dan materialisme, kemudian pandangan terhadap peran etika dan TJSP adalah variabel dependennya. Regresi linier berganda digunakan untuk menganalisis model pengaruh yang terbentuk dan independent sample T-test digunakan untuk melihat kemungkinan munculnya perbedaan persepsi. Hasil analisis penelitian ini menunjukkan bahwa idealisme memiliki pengaruh positif terhadap pandangan akan peran etika dan TJSP, kemudian relativisme dan materialisme sama-sama memiliki pengaruh negatif terhadap pandangan akan peran etika dan TJSP.
Submitted Article Do Consumer Responses to Media Food Safety Information Last

Using experimental methods with adult subjects from the mid- Atlantic region of the United States, this research examines both the short- and longer-term impacts of media information on consumer purchasing behavior. Subjects in the treatment group were given food safety information about poultry from a popular consumer magazine. Willingness to pay (WTP) estimates were then elicited for two types of chicken breasts: (1) a leading-brand that was identi- fied in the information treatment as having a high incidence of Campylobacter and Salmonella bacteria; and (2) a lesser known brand, which was reported as being relatively free of harmful bacteria. Results indicated that both negative and positive food safety information significantly impacted consumers' WTP for safer chicken compared to the reportedly less-safe leading-brand chicken. These changes in behavior persisted throughout the seven-week study period.
Empiracal Study of Students' Computer Security Practices/Perceptions

For several decades computer security has been gaining in importance to organizations. In today's corporate computing environment with widespread information sharing over the Web, computer security has become an even more vital concern as threats to corporate computers continue to grow. The purpose of this article is to present the results of an empirical study of the security practices and perceptions of the next generation of corporate computer users–undergraduate university students. Specifically, this study surveyed students majoring in Computer Information Systems, Art, and Integrated Science and Technology. The findings relate to the students usage of: antivirus programs; firewalls; opening attachments; password security; and security patches. Student perceptions of computer security and its importance are also reported.
What is the affect of an online orientation course on student satisfaction

What is affect of an online orientation course on student satisfaction? A Chi-Square non-parametric test was utilized to provide a statistical analysis of the participants’ responses. Findings indicated that online students should have a mandatory online orientation in the online environment. Education stakeholders should utilize these findings to develop a policy on mandatory online orientation programs.
HNPCC, Molecular and Clinical Dilemmas

Hereditary non-polyposis colorectal cancer (HNPCC) is the most common genetic susceptibility syndrome for colorectal cancer. HNPCC is most frequently caused by germline mutations in the DNA mismatch repair (MMR) genes MSH2 and MLH1. Recently, mutations in another MMR gene,MSH6 (also known as GTBP), have also been shown to result in HNPCC. Preliminary data indicate that the phenotype related to MSH6 mutations may diVer from the classical HNPCC caused by defects inMSH2 andMLH1. Here, we describe an extended Dutch HNPCC family not fulfilling the Amsterdam criteria II and resulting from aMSH6 mutation. Overall, the penetrance of colorectal cancer appears to be significantly decreased (p<0.001) among the MSH6 mutation carriers in this family when compared with MSH2 and MLH1 carriers (32% by the age of 80 v >80%). Endometrial cancer is a frequent manifestation among female carriers (six out of 13 malignant tumours). Transitional cell carcinoma of the urinary tract is also relatively common in both male and female carriers (10% of the carriers). Moreover, the mean age of onset of both colorectal cancer (MSH6 v MSH2/MLH1 = 55 years v 44/41 years) and endometrial carcinomas (MSH6 v MSH2/MLH1 = 55 years v 49/48 years) is delayed. As previously reported, we confirm that the pattern of microsatellite instability, in combination with immunohistochemical analysis, can predict the presence of a MSH6 germline defect. The detailed characterisation of the clinical phenotype of this kindred contributes to the establishment of genotypephenotype correlations in HNPCC owing to mutations in specific mismatch repair genes. (J Med Genet 2001;38:318–322)
Phase 3 study evaluating efficacy and safety of veliparib (V) plus carboplatin (Cb) or Cb in combination with standard neoadjuvant chemotherapy (NAC) in patients (pts) with early stage triple-negative breast cancer (TNBC).

520Background: Clinical studies suggest that TNBC is sensitive to DNA-damaging agents, including Cb. V is a potent PARP inhibitor that may enhance the antitumor activity of such agents. We present primary response data from a phase 3 randomized, placebo-controlled study (NCT02032277) evaluating the addition of V + Cb or Cb to neoadjuvant paclitaxel (P) followed by doxorubicin + cyclophosphamide (AC). Methods: Pts with histologically confirmed, invasive TNBC (T2–T4 N0–2 or T1 N1–2) amenable to surgical resection were randomized 2:1:1 to (Arm A) P 80 mg/m2 weekly + Cb AUC 6 mg/mL/min q3 weeks + V 50 mg PO BID; (Arm B) P + Cb + PO placebo; or (Arm C) P + IV placebo + PO placebo, for 12 weeks followed by AC (60 mg/m2 or 600 mg/m2 q2 or 3 weeks) × 4. Primary endpoint was pathologic complete response (pCR) in breast and nodes with > 80% power at 2-sided α of 0.05 using pair-wise comparisons for A vs B and A vs C to detect significant treatment effects using Χ2 test; secondary endpoint was rate of conversion to .
The epidemiology of intermediate footrot

Under the Copyright Act 1968 (several provision of which are referred to below), this thesis must be used only under the normal conditions of scholarly fair dealing for the purposes of research, criticism or review. In particular no results or conclusions should be extracted from tt, nor should it be copied or closely paraphrased in whole or in part without the written consent of the author. Proper written acknowledgement should be made for any assistance obtained from this thesis.
Sexual Role and History of Sexual Transmited Infection as a Risk of HIV Seroconversion among Men who have Sex with Men who Attended Bali Medika Clinic Badung, Bali

Background and purpose: HIV prevalence among men who haved sex with men (MSM) increased from 5% on 2007 into 12% on 2011 in Indonesia. High risk sex behaviour was reported associated with HIV seroconversion, however reported research publication about risk factors of HIV seroconvertion among MSM is limited in Indonesia. This study aim to investigate risk factors of HIV seroconversion among MSM.Methods: Case control study was conducted based on cohort data from MSM which repeatetly visit Bali Medika Clinic, Kuta, Badung, Bali Province between 2011-2015. HIV Seroconversion was defined as MSM with a negative HIV status at the beginning of the observation and became positive on the next visit. Data were analyzed using Kaplan Meier and logistic regression method.Results: Median time of HIV seroconversion among MSM was 458 days or 1.2 years (IQR=224-699). Multivariate analysis showed that risk factors of HIV seroconversion were repeated STD's experience in the last 6 months with AOR=8.33 (95%CI: 1.77-89.81); had 1 time STD's history in last 6 months with AOR=1.91 (95%CI: 1.15-3.83); receptive sexual relationship in the last 6 months with AOR=3,45 (95%CI: 1.68-7.11); and versatile sexual relationship in the last 6 months with AOR=2.37 (95%CI: 1.09-5.13). Conclusion: STD's experience, receptive and versatile sexual role was reported as risk factors of HIV seroconversion among MSM.
Solving programming problems in intelligent programming tutors for teaching the object-oriented programming paradigm

This paper basically describes the artificial intelligence structures and techniques used to solve programming problems in a generic architecture for the development of intelligent programming tutors to tutor the object-oriented programming paradigm. Each problem is depicted in terms of a program specification describing the task to be performed, and a knowledge base consisting of conceptual graphs representing the problem application domain. Solving a programming problem essentially involves developing an object-oriented design, developing algorithms for the methods of the classes and the overall program, and implementing these algorithms in a particular language. A description of the artificial intelligence techniques used to generate object-oriented designs and induce the necessary algorithms is provided Finally, the paper describes additional extensions that need to be made to the Expert Module of the architecture for the purpose of problem solving.
The impact of comorbidities on the management and prognosis of oropharyngeal and hypopharyngeal cancer patients in Taiwan

Background: Comorbidity is often associated with negative outcome of prognosis. The aim of this study was to investigate the prevalence and impact of comorbidities in a retrospective nationwide population-based study of patients with oropharyngeal and hypopharyngeal cancers in Taiwan. Materials and Methods: A total of 4733 oropharyngeal and hypopharyngeal cancer patients diagnosed in the period 2007–2010 were identified through the Taiwan Cancer Registry (TCR) database. By linking this data set to the National Health Insurance Research Database (NHIRD) and the Death Registry (DR), information on comorbidity and cause of death was obtained and adapted to the Charlson’s comorbidity index (CCI). The influence of comorbidity on overall survival and cancer-related death was evaluated by Kaplan–Meier estimates and Cox regressions. Results: There were 23.5% of patients with comorbidities during the year before cancer diagnosis. Patients with comorbidities are associated with lower survival rates for stage 3 and for oropharynx. Although there was a tendency that patients with comorbidities received less curative treatment within the same cancer stage, the statistical significance was not reached. The data suggest having a co-morbidity condition had a significant effect on all-cause death (age and gender adjusted hazard ratios = 0.68-0.40) but no significance in cancer-related deaths. Conclusion: The cancer management was not significantly different between patients’ comorbidity conditions. However, the larger differences between all-cause and cancer-specific survival rates in certain treatment groups emphasize the importance of managing other medical conditions in cancer patients.
Confronting the Challenges of Graduate Education in Sub-Saharan Africa and Prospects for the Future

This study examines the current status of graduate education in Sub- Saharan Africa. How has it been affected by the decline in donor funding, economic crises in much of Africa, the phenomenal growth in undergraduate education, and a shortage of faculty members with PhDs. One of the authors suggested in an earlier study that a short-term response to the shortage of high quality graduate education might be regional graduate centers. Has that taken place? To what extent has graduate education improved and expanded? Where has growth taken place? We explore challenges facing the development of high quality graduate education including those of recruitment and retention, efforts to improve the qualifications of faculty members, funding issues, as well as research and publications. Several innovative graduate programs are examined. Finally, we make recommendations for the growth and quality improvement of graduate education including rekindling a culture of research, a focus on quality teaching, and the critical need for major investments in high quality graduate education. Cette analyse s’interesse au statut des etudes de master et de doctorat en Afrique subsaharienne. Comment ont-elles ete affectees par la diminution des dons financiers, les crises economiques dans toute l’Afrique, la croissance phenomenale du nombre d’etudiants en licence, et le manque de professeurs titulaires d’un doctorat ? Un des auteurs a suggere dans de precedents travaux une reponse a court-terme a la penurie de diplomes de master et de doctorat d’excellent niveau : des centres regionaux consacres aux etudes de masters et de doctorat. Ceci a t-il ete mis en place ? Dans quelle mesure les formations de master et de doctorat se sont-elles ameliorees et leur nombre a t-il augmente ? Ou la croissance a t-elle eu lieu ? Nous nous attardons sur les obstacles au developpement de formations de master et de doctorat de qualite, en particulier ceux de recrutement et de retention des etudiants, les efforts pour ameliorer les qualifications des professeurs, la situation financiere ainsi que la recherche et les publications. Plusieurs formations innovantes de master et de doctorat sont examinees. Finalement, nous proposons des recommandations pour la croissance et l’amelioration de la qualite des etudes de master et de doctorat, notamment raviver la culture de recherche, se concentrer sur la qualite de l’enseignement, et le besoin critique d’investissements majeurs dans des masters et doctorats de qualite.
Morphology in language comprehension, production and acquisition

This Special Issue on Morphological Processing is based on the sixth MOrphological PROcessing Conference (MOPROC), which was kept in June 2009 in Turku, Finland. The issue contains 13 articles by leading scholars in the field of morphological processing. These articles investigate the role morphemes play in language comprehension, production and acquisition. Specific questions relate to the time course with which morphemes come available, what factors facilitate their use, the role of orthographic and semantic transparency in complex word processing and how morphology should be incorporated in models of word processing. The papers in this issue provide a wealth of empirical results in several languages obtained with state-of-the-art experimental paradigms and will be an inspiration for further studies in morphological processing.
Theory and Practice in Late Nineteenth-Century Violin Performance: An Examination of Style in Performance, 1850–1900

With most of Western art music, it can be argued that music-making requires performers to interpret a composer's original, notated ideas. Often, an informed and perceptive reading of the score needs to be combined with the inspiration to convey the feelings and emotions intended by the composer. The difficulties inherent in such an undertaking are further heightened when the music was composed several generations ago. In this book, David Milsom argues that in order to convey late 19th-century musical style appropriately, the performer needs to have a grasp of the philosophical orientation of musical thinking at that time. In effect, one must "unlearn" the value systems of the present, in order to assimilate those of the late 19th century. To arrive at a better understanding of performance in this period, the book examines performing style in the German and Franco-Belgian schools of violin playing from c.1850 - c.1900. Milsom explores selected instrumental treatises written by noted players and theorists, together with a number of recorded performances given by celebrated artists in the early years of the 20th century, to review the similarities and differences between theory and practice. An accompanying CD illustrates this relationship.
Poetic Rhythm: An Introduction

Preface Acknowledgments On using this book 1. The rhythms of poetry: a first approach 2. The rhythms of spoken English 3. Dancing language 4. Stress verse and strong-stress verse: counting the beats 5. Syllable-stress verse: versatility and variation 6. Major types of syllable-stress verse 7. Free verse: metrical and rhythmic analysis 8. Phrasal movement Appendix 1. Scansion Appendix 2. Glossary Appendix 3. Sources of examples Appendix 4. Suggested responses to the exercises.
Rehearsal world: programming by rehearsal

A tough, high bulk, flexible fabric is provided which has a grainy wrinkled texture with a multiplicity of transversely discontinuous furrows and ridges. The fabric is somewhat elastic, especially in the machine direction, and comprises a corrugated web of initially alined textile fibers implanted in a continuous thin film of thermoplastic adhesive, the fiber-adhesive web thereafter being corrugated into a multitude of furrows and grooves with irregularly root- and side-connected convolutions. The fabric is produced by implanting the fibers into the thermoplastic adhesive film, adhering the resulting web onto an abherent heated surface, and advancing the surface against a gathering blade to corrugate the web and form irregularly root- and side-connected sinusoidal convolutions.