Miracle-dz/UniFAR-FTUs huggingface dataset:
Does residual cement around implant-supported restorations cause peri-implant disease? A retrospective case analysis.

OBJECTIVES The purpose of this study was to determine the relationship between patients with a history of periodontitis and development of cement-related peri-implant disease. MATERIALS AND METHODS Seventy-seven patients with 129 implants for this retrospective analysis were selected from completed implant cases that were scheduled for regular maintenance or had experienced mechanical or biological complications between years 2006 and 2011 in private practice. Implants with extracoronal residual cement and implants without cement remnants were analyzed. The selected cases were further divided into two groups--implants in patients with history of periodontitis (1) and implants in periodontitis-free individuals (2). The selection of these groups was made on the basis of treatment history and orthopantomograph. As a control group, a set of 238 screw-retained implant restorations, delivered to 66 patients during the same period of time was examined. The incidence of peri-implant disease among implants in all groups was calculated. RESULTS Peri-implant disease was evident in 62 of 73 implants with cement remnants (85%). All implants in group 1 developed peri-implantitis--4 early and 35 delayed disease cases. In the periodontally healthy group, 20 of 31 implants were diagnosed with peri-implant mucositis, 3 implants had early peri-implantitis, and 11 implants with cement remnants did not develop biological complications. In the group of implants without cement remnants, peri-implant disease was diagnosed in 17 of 56 cases (30%). In contrast, only two occurrences of peri-implant disease were registered in the control group of screw-retained restorations (1.08%). CONCLUSIONS Implants with cement remnants in patients with history of periodontitis may be more likely to develop peri-implantitis, compared with patients without history of periodontal infection.
Circulating relaxin acts on subfornical organ neurons to stimulate water drinking in the rat

Relaxin, a peptide hormone secreted by the corpus luteum during pregnancy, exerts actions on reproductive tissues such as the pubic symphysis, uterus, and cervix. It may also influence body fluid balance by actions on the brain to stimulate thirst and vasopressin secretion. We mapped the sites in the brain that are activated by i.v. infusion of a dipsogenic dose of relaxin (25 μg/h) by immunohistochemically detecting Fos expression. Relaxin administration resulted in increased Fos expression in the subfornical organ (SFO), organum vasculosum of the lamina terminalis (OVLT), median preoptic nucleus, and magnocellular neurons in the supraoptic and paraventricular nuclei. Ablation of the SFO abolished relaxin-induced water drinking, but did not prevent increased Fos expression in the OVLT, supraoptic or paraventricular nuclei. Although ablation of the OVLT did not inhibit relaxin-induced drinking, it did cause a large reduction in Fos expression in the supraoptic nucleus and posterior magnocellular subdivision of the paraventricular nucleus. In vitro single-unit recording of electrical activity of neurons in isolated slices of the SFO showed that relaxin (10−7 M) added to the perfusion medium caused marked and prolonged increase in neuronal activity. Most of these neurons also responded to 10−7 M angiotensin II. The data indicate that blood-borne relaxin can directly stimulate neurons in the SFO to initiate water drinking. It is likely that circulating relaxin also stimulates neurons in the OVLT that influence vasopressin secretion. These two circumventricular organs that lack a blood–brain barrier may have regulatory influences on fluid balance during pregnancy in rats.
Comparison of Basic Direct Torque Control Designs for Permanent Magnet Synchronous Motor

Basic PMSM-DTC drive controller consists of flux and torque hysteresis comparators and switching table. In the literature, three different designs have been reported. This paper investigates the three designs and compares their performance. The study aims to trace the reasons behind the recommendation of avoiding zero voltage states for PMSM- DTC reported in some studies. The system which avoids the zero states is compared with two systems include the zero states in their switching tables. The three systems are compared in their response time, switching losses, torque and flux ripples with three different input commands. The results as well as the theoretical discussion, show that the zero states should not be excluded from the switching table. The study concludes that the two level torque comparator, eight-state table design is suitable for two quadrant drives, while the three-level comparator, eight-state table is the most suitable for the four-quadrant drives.
Diagnostic Usefulness of Ribosomal Protein L7/L12 for Pneumococcal Pneumonia in a Mouse Model

ABSTRACT The capsular antigen detection (CAD) kit is widely used in clinics to detect Streptococcus pneumoniae infection from urine, because it is rapid, convenient, and effective. However, there are several disadvantages, including false-positive results in children colonized with S. pneumoniae and prolonged positive readings even after the bacteria have been cleared. RP-L7/L12 is a component of the 50S ribosome that is abundant in all bacteria and is specific for each bacterial species. We investigated whether RP-L7/L12 could be used to accurately diagnose pneumococcal pneumonia infection in mouse models of pneumonia and colonization generated by infecting CBA/JN or CBA/N mice, respectively, with S. pneumoniae strain 741. RP-L7/L12 detection by enzyme-linked immunosorbent assay accurately assessed active lung infection, as RP-L7/L12 levels decreased simultaneously with the bacterial lung burden after imipenem administration in the pneumonia mouse model. Based on the data, antibodies detecting RP-L7/L12 were applied to rapid immunochromatographic strips (ICS) for urine sample testing. When we compared the ICS test with the CAD kit in the pneumonia model, the results correlated well. Interestingly, however, when the lung bacterial burden became undetectable after antibiotic treatment, the ICS test was correspondingly negative, even though the same samples tested by the CAD kit remained positive. Similarly, while the ICS test exhibited negative results in the nasal colonization model, the CAD kit demonstrated positive results. Bacterial RP-L7/L12 may be a promising target for the development of new methods to diagnose infectious disease. Further studies are warranted to determine whether such a test could be useful in children.
Quality of Life in Contemporary Nursing Theory

A critical appraisal of the concept, quality of life, as used in nursing theories, is presented in a historically situated context. This approach to concept analysis was selected to illuminate the subjective, contextual, and fluid nature of the concept. Based on this review, quality of life is defined as an intangible, subjective perception of one's lived experience. From a review of Peplau's, Rogers', Leininger's, King's, and Parse's conceptualizations of quality of life, it is concluded that it may be viable to replace health with quality of life as a metaparadigm concept for nursing.
The Human Candidate Tumor Suppressor Gene HIC1 Recruits CtBP through a Degenerate GLDLSKK Motif

ABSTRACT HIC1 (hypermethylated in cancer) and its close relative HRG22 (HIC1-related gene on chromosome 22) encode transcriptional repressors with five C2H2 zinc fingers and an N-terminal BTB/POZ autonomous transcriptional repression domain that is unable to recruit histone deacetylases (HDACs). Alignment of the HIC1 and HRG22 proteins from various species highlighted a perfectly conserved GLDLSKK/R motif highly related to the consensus CtBP interaction motif (PXDLSXK/R), except for the replacement of the virtually invariant proline by a glycine. HIC1 strongly interacts with mCtBP1 both in vivo and in vitro through this conserved GLDLSKK motif, thus extending the CtBP consensus binding site. The BTB/POZ domain does not interact with mCtBP1, but the dimerization of HIC1 through this domain is required for the interaction with mCtBP1. When tethered to DNA by fusion with the Gal4 DNA-binding domain, the HIC1 central region represses transcription through interactions with CtBP in a trichostatin A-sensitive manner. In conclusion, our results demonstrate that HIC1 mediates transcriptional repression by both HDAC-independent and HDAC-dependent mechanisms and show that CtBP is a HIC1 corepressor that is recruited via a variant binding site.
Fixed rate universal block source coding with a fidelity criterion

A unified theory is developed for fixed rate block source encoding subject to a fidelity criterion in incompletely or inaccurately specified stationary statistical environments. Several definitions of universal encoding are given and compared, and the appropriate theorems are stated and proved for each. The new results and approaches are compared and contrasted with earlier related results of Ziv.
Amino Acid Exchanges in the Putative Nuclear Export Signal of Adenovirus Type 5 L4-100K Severely Reduce Viral Progeny due to Effects on Hexon Biogenesis

ABSTRACT The adenovirus type 5 nonstructural L4-100K protein is indispensable for efficient lytic infection. During the late phase, L4-100K promotes selective translation of viral late transcripts and mediates the trimerization of the major capsid protein hexon. In the present study, the role of a potential nuclear export signal in L4-100K was investigated. Intriguingly, amino acid substitutions in this sequence resulted in severely diminished progeny virus production, seemingly by precluding proper hexon biogenesis.
Callous-Unemotional Traits Moderate Genetic and Environmental Influences on Rule-Breaking and Aggression: Evidence for Gene × Trait Interaction

Previous behavioral genetic research in children has found that conduct problems in the presence of high CU traits are more heritable than conduct problems in the presence of low CU traits—a gene × trait interaction. The current study replicates and extends this finding using a sample of adolescent twins from the Texas Twin Project, who were assessed for rule-breaking and aggression. We find evidence that genetic influences on CU traits contribute to genetic liability for both rule-breaking and aggressive behavior. CU traits moderate genetic influences on aggressive behavior, such that the heritability of aggression is higher among youth with high levels of CU traits. However, we do not find evidence that CU traits moderate genetic influences on rule-breaking behavior. The continuum of callous-unemotionality and the aggression versus rule-breaking distinction continues to be meaningful and intersecting methods for characterizing heterogeneity in the etiology of antisocial behavior.
Upper Steptoean (Upper Cambrian) Trilobites from the Mckay Group of Southeastern British Columbia, Canada

An abundant and well preserved trilobite fauna is described from Upper Cambrian calcareous mudstones of the McKay Group, near Cranbrook in southeastern British Columbia. The trilobites are mostly articulated, consisting of similar numbers of molts and carcasses. They are representative of a new deep water biofacies, the Wujiajiania Biofacies, and a new Wujiajiania sutherlandi Fauna of late Steptoean age. The trilobites were collected from a narrow interval (<20 m thick) of richly fossiliferous strata, in a thick sequence of unfossiliferous to sparsely fossiliferous strata of similar lithology. The fauna includes fourteen species, six of which are new: Aciculolenus palmeri, Burnetiella leechi, Hedinaspis canadensis, Labiostria westropi, Pterocephalia norfordi, and Wujiajiania sutherlandi.
Fundamentals of tracer kinetics for dynamic contrast‐enhanced MRI

Tracer kinetic methods employed for quantitative analysis of dynamic contrast‐enhanced (DCE) magnetic resonance imaging (MRI) share common roots with earlier tracer studies involving arterial‐venous sampling and other dynamic imaging modalities. This article reviews the essential foundation concepts and principles in tracer kinetics that are relevant to DCE MRI, including the notions of impulse response and convolution, which are central to the analysis of DCE MRI data. We further examine the formulation and solutions of various compartmental models frequently used in the literature. Topics of recent interest in the processing of DCE MRI data, such as the account of water exchange and the use of reference tissue methods to obviate the measurement of an arterial input, are also discussed. Although the primary focus of this review is on the tracer models and methods for T1‐weighted DCE MRI, some of these concepts and methods are also applicable for analysis of dynamic susceptibility contrast‐enhanced MRI data. J. Magn. Reson. Imaging 2011;. © 2011 Wiley Periodicals, Inc.
Involvement of the Renin–Angiotensin System in Ischemic Damage and Reperfusion Arrhythmias in the Isolated Perfused Rat Heart

We have investigated the contribution of the renin–angiotensin system to the damage caused by 40-min global ischemia in the isolated rat heart. A converting enzyme inhibitor, enalaprilat (70 nM). an angiotensin II receptor antagonist, compound 89 (2 μM), and an inhibitor of rat renin, CGP 44099A (20 nM), given before ischemia reduced the median duration of ventricular fibrillation on reperfusion to a similar extent (5.53, 5.72, and 5.14 min, respectively, compared to 13.98 min in the control group) but had no effect on creatine phosphokinase release (22.2 ± 2.6, 22.1 ± 6.8, and 24.1 ± 3.6, IU/30 min, respectively, compared to 19.9 ± 1.9 IU/30 min) or recovery of left ventricular developed pressure (67 ± 6, 73 ± 7 and 71 ± 6%, respectively, compared to 66 ± 30 after 30 min reperfusion). The increase in coronary resistance and left ventricular diastolic pressure on reperfusion was not affected by any of the agents. All three agents also tended to reduce the duration of ventricular fibrillation when given only on reperfusion. We conclude that angiotensinogen is present in the rat heart and it is converted to angiotensin I by a renin or a renin-like aspartic proteinase. The angiotensin I is converted to angiotensin II by converting enzyme. The angiotensin II formed is an important mediator of postreperfusion ventricular fibrillation in the isolated rat heart but does not contribute to the reduction in mechanical function produced by global ischemia in this preparation.
Effects of Mycotoxins on Ruminal Bacteria and Animal Performance

Dairy producers have a difficult task when attempting to assess the possible exposure of their animals to mycotoxins. Information gleaned from the scientific literature suggests signs and symptoms for toxins which may actually not be likely to appear in a herd. Also, that same literature suggests concentrations at which the toxin exerts its effects. Those concentrations may have little meaning in a production setting in which multiple mycotoxins, as well as other production stresses, are at work. We do know, however, that mycotoxins do pass through the dairy cow’s rumen intact, although clearly some microbial metabolism can and does take place. At the same time, the mycotoxins may produce adverse affects on key rumen bacteria. Therefore, we cannot count on rumen microbiology to protect the dairy animal. Predicting signs which might occur in the herd exposed to mycotoxins is also futile. Such signs are generally not unique to particular mycotoxins if to toxic compounds at all. Changes in productivity, in reproductive capacity, in general health, behavior, etc. may all signal the presence of mycotoxins, although other causes may be equally to blame. The present report discusses some of these factors and suggests the approach dairy farmers may find most productive in dealing with the issue of mycotoxin contamination on their farms.
Does differential adhesion govern self-assembly processes in histogenesis? Equilibrium configurations and the emergence of a hierarchy among populations of embryonic cells.

The differential adhesion hypothesis attributes sorting-out behavior of embryonic cells to differences in the strengths of their intercellular adhesions. It suggests that cells in mixed populations rearrange themselves to minimize their total adhesive free energy. The final configuration adopted is viewed as approaching a moststable or equilibrium configuration, with the less cohesive cell/population tending to envelop the more cohesive one. The hypothesis enables two predictions to be made. First, if the final configuration adopted by a mixed cell population indeed approximates an equilibrium configuration, the same final configuration should be approached irrespective of the starting configuration. Second, comparison of the equilibrium configurations for all possible pair-combinations of a series of cell populations of different types should reveal a hierarchy of “preference” for the internal position, reflecting a hierarchy of cellular cohesiveness. These predictions have been tested and confirmed. First, any particular pair of tissues approaches the same final configuration, irrepective of whether the cells are initially randomly intermixed or tissue fragments are laterally joined. Second, the predicted hierarchy of preference for the internal position has been found, consistent with a hierarchy of cellular cohesiveness. An effort has been made to clarify confusions that have arisen concerning the differential adhesion hypothesis. It is particularly stressed that the hypothesis offers an explanation for cell population behavior in terms of relative strengths of cell adhesions and makes no proposals concernnig the chemistry of adhesion. However, the value of equilibrium configurations in guiding biochemical investigations of cell surface adhesives is pointed out, as is the relevance of the present observations to natural morphogenetic events.
Exercise and Healthy Eating Intentions and Behaviors among Normal Weight and Overweight/Obese Adults

Strong evidence suggests that exercise and eating behaviours are strongly linked. Theory of Planned Behaviour is a theoretical framework that has been successfully used to explain and predict both behaviours. The aim of the present study is to explore the constructs of Theory of Planned Behavior (TPB) that better predicts exercise and healthy eating: a) intentions and b) self- reported behaviors among normal weight and overweight/obese adults. Participants were 361 adults in Greece (women: N = 152). According to their BMI scores, they have been grouped into normal weight and overweight/obese. Data were collected with an online questionnaire assessing variables of the theory of planned behavior (TPB) toward exercise and healthy eating intentions and behaviors. Correlations between the variables of TPB and behaviors (healthy eating and exercise) were higher in the normal weight group than in the overweight/obese group. The strongest predictor of intention to exercise was perceived behavioral control for both groups with the overweight/obese group showing higher values in comparison to normal weight group values. The same associations emerged for the prediction of intention for healthy eating behavior. The attitude was also a statistically significant predictor for both groups with higher values in normal weight group. The strongest predictor of exercise behavior was the intention, whereas for eating behavior significant predictors were attitudes, intentions and perceived behavioral control. TPB framework explained both intentions and behaviors for exercise and healthy eating of normal weight and overweight/obese adults. Initial information on which TPB constructs explain better intentions and behaviors by group implied that normal weight group has more positive exercise and healthy eating attitudes and intentions than the overweight/obese group; the behaviors of the overweight/obese group were explained better by perceived behavioral control. The above information can be used to design more effective interventions that aim to produce changes in both behaviors.
Phonological Skills and Learning to Read

Phonological Awareness and Reading. How Children Read Words. Spelling and Phonological Awareness. How Children Read and Write New Words. Comparisons with Backward Readers and Spellers. Correlations and Longitudinal Predictions. Teaching Children About Sound. Do Children Read and Fail to Learn to Read in Different Ways from Each Other. Theories About Learning to Read.
The role of family firm image perception in host-guest value co-creation of hospitality firms

ABSTRACT Customers value the services and products of family firms. Especially the rural hospitality industry is dominated by family firms and shaped by high-contact services, where hosts and guests co-create value. Hypothesizing that behavioural and relational qualities of family firms are a central source for value co-creation and that a perceived family firm image (FFI) affects guests in co-creating value, this study investigates the effect of three relevant principles (trust, relationship commitment, social interaction ties) on value co-creation under the influence of FFI perception. The model is tested on a sample of 331 guests of Austrian rural hospitality firms. Findings show that relationship commitment and social interaction ties influence value co-creation, and a perceived FFI in particular strengthens the effect of social interaction ties on value co-creation. Implications suggest installing facilitators of value co-creation, enhancing the FFI via social capital and further investigating the customer perception of family firms in the rural hospitality industry and beyond.
Fast Dissolving Oral Films: A Review

Buccal drug delivery has lately become an important route of drug administration. But many of the patients (pediatric and geriatric) are unwilling to take solid preparations due to fear of choking. This has made the pharmaceutical industry look for alternative routes of drug delivery like film drug delivery. Fast dissolving oral drug delivery systems have started gaining popularity and acceptance as new drug delivery systems, because they are easy to administer, better patient compliance, rapid drug absorption and sudden-onset of drug action with instant bioavailability is possible. So, now-a-days, most of the pharmaceutical companies adopted various technologies to manufacture fast dissolving oral films in large scale despite of several limitations as an alternative to traditional over-the-counter medicine forms such as tablets, capsules etc. This review reflects information regarding formulation ingredients, technologies and evaluation tests employed in the preparation of fast dissolving oral films.