Miracle-dz/UniFAR-FTUs huggingface dataset:
Variance and covariance components for weaning weight for Herefords in three countries.

Records from the Hereford Associations of the United States (USA), Canada, and Uruguay were used to estimate genetic and phenotypic variances and covariances for weaning weight. Estimation was done using a complete animal model, relatively large data sets, and the same methodology for the three countries in order to determine whether genetic parameters for weaning weight were homogeneous across environments. Data were composed of 2,322,722, 487,661, and 102,986 edited weaning weight records for USA, Canada, and Uruguay, respectively. Ten samples were obtained from each country by eliminating data from small herds with fewer than 500 records, selecting herds at random from the entire data set after removing the small herds, and then retaining the direct-sire-connected contemporary groups within each sample. The final sample sizes ranged from 9,832 to 46,377 records. An accelerated EM-REML algorithm was used in estimating the (co)variance components in each sample. The estimates were pooled by calculating the arithmetic mean of the 10 samples from within each country. Direct and maternal (in parentheses) heritability estimates were . 24 (.16), . 20 (.16), and . 23 (.18) for USA, Canada, and Uruguay, respectively. Maternal heritabilities reported here are nearly 50% smaller than the values currently used in national genetic evaluation for the breed, which were estimated using sire-maternal grandsire models. Covariance between direct and maternal was negative in all countries, accounting for 6, 8, and 10% of the total phenotypic variation, and the total dam effect was 32.5, 37.0, and 34.0% in USA, Canada, and Uruguay, respectively. Total heritabilities were similar among the countries, with values of . 19, . 19, and . 17 for the three respective countries. The similarity of genetic and environmental parameters across the three countries suggests that joint genetic evaluation is feasible across environments provided that the genotype x environment interaction is negligible and can be ignored.
Dexmedetomidine and clonidine inhibit ventricular tachyarrhythmias in a rabbit model of acquired long QT syndrome.

BACKGROUND Agents with α-2 adrenoreceptor (AR) agonistic action have reportedly suppressed tachyarrhythmias. METHODS AND RESULTS We hypothesized that α-2 AR agonists would have an inhibitory effect on abnormal repolarization-related ventricular tachyarrhythmias (VTs). To test this hypothesis, the effects of 2 clinically available α-2 AR agonists (dexmedetomidine and clonidine) on the occurrence of VTs were assessed in a methoxamine-sensitized rabbit model of acquired long QT syndrome (Study 1: n=45). In control rabbits, administration of methoxamine and nifekalant almost invariably caused VTs (14/15). In contrast, incidence of VT significantly decreased during the treatment with dexmedetomidine (1μg·kg(-1)·min(-1): 5/12 [P<0.01 vs. control]) or with clonidine (33.3μg·kg(-1)·min(-1): 10/18 [P<0.01]). To verify that VTs in this animal model are triggered by early afterdepolarization (EAD), the monophasic action potential on the left ventricular surface was recorded in 28 open-chest rabbits (Study 2). EAD-like hump was less frequently detected during treatment with clonidine or dexmedetomidine (2/14) than in saline-treated rabbits (9/10, P<0.005). Presence of a hump was significantly related to the advent of VTs (P<0.05). CONCLUSIONS Agents with α-2 AR agonistic action have an inhibitory effect on VTs in a rabbit model of long QT syndrome. Alpha-2 AR agonists, especially dexmedetomidine, may be a therapeutic choice for abnormal repolarization-related VTs that are resistant to conventional treatment.
Short hydration in chemotherapy containing cisplatin (≥75 mg/m2) for patients with lung cancer: a prospective study.

OBJECTIVE We previously reported that 22% of lung cancer patients experienced a Grade 2 or 3 elevation in creatinine after chemotherapy containing cisplatin. We conducted a Phase II trial to evaluate the safety and efficacy of short hydration. METHODS The major eligibility criteria included patients with lung cancer for whom a ≥75 mg/m(2) cisplatin-based regimen was indicated and adequate organ function. Cisplatin was administered with pre- and post-hydration containing 10 mEq of potassium chloride in 500 ml of fluid over a 60-min period. Immediately before the administration of cisplatin, mannitol (20%, 200 ml) was administered as forced diuresis over 30 min. And magnesium sulfate (8 mEq) was added to pre-hydration. RESULTS Forty-four patients were enrolled between April and December 2011. The patients included 29 men and 15 women with a median (range) age of 64 (42-74) years. Twenty patients received cisplatin and pemetrexed as their most frequent regimen and 38 patients received three to four cycles of chemotherapy. The median (range) duration and volume of the chemotherapies were 4.0 (3.3-6.8) h and 1600 (1550-2050) ml, respectively. Of the 44 patients, 43 (97.8%) completed the cisplatin-based chemotherapy without Grade 2 or higher renal dysfunction. The only patient who had Grade 2 elevation in creatinine (maximum value 1.7 mg/dl) had prompt improvement in creatinine levels and completed four cycles of chemotherapy. CONCLUSIONS The short hydration is safe without severe renal toxicities in regimens containing cisplatin (≥75 mg/m(2)) for patients with lung cancer.
The effect of deprivation on the developmental activities of adolescent rugby union players in Wales

ABSTRACT The developmental activities of rugby union players and their interaction with deprivation remain to be elucidated. Five-hundred and ninety elite junior rugby union players (14.8 ± 0.5 years) were split into deprivation quintiles. These players subsequently completed a participant history questionnaire to record their involvement in rugby and other sports. Players accumulated 1987 ± 1297 h in rugby between 6 and 15 years of age. During the mini rugby stage (6–10 years of age), players accumulated an average of 113 ± 105, 89 ± 69 and 43 ± 19 h per year in rugby play, practice and competition, respectively. Moreover, 461 players engaged in an average of two other sports during the mini rugby stage. During the junior rugby stage (11–15 years of age), players accumulated 179 ± 98, 115 ± 90 and 64 ± 26 h per year in rugby practice, play and competition, respectively, and 538 players took part in three other sports. Players who were more deprived accumulated less rugby hours and participated in fewer other sports, but age milestones were not different between deprivation quintiles. There were no differences within developmental activities in rugby between deprivation groups.
Functions of AMP‐activated protein kinase in adipose tissue

AMP‐activated protein kinase (AMPK) is involved in cellular energy homeostasis. Its functions have been extensively studied in muscles and liver. AMPK stimulates pathways which increase energy production (glucose transport, fatty acid oxidation) and switches off pathways which consume energy (lipogenesis, protein synthesis, gluconeogenesis). This has led to the concept that AMPK has an interesting pharmaceutical potential in situations of insulin resistance and it is indeed the target of existing drugs and hormones which improve insulin sensitivity. Adipose tissue is a key player in energy metabolism through the release of substrates and hormones involved in metabolism and insulin sensitivity. Activation of AMPK in adipose tissue can be achieved through situations such as fasting and exercise. Leptin and adiponectin as well as hypoglycaemic drugs are activators of adipose tissue AMPK. This activation probably involves changes in the AMP/ATP ratio and the upstream kinase LKB1. When activated, AMPK limits fatty acid efflux from adipocytes and favours local fatty acid oxidation. Since fatty acids have a key role in insulin resistance, especially in muscles, activating AMPK in adipose tissue might be found to be beneficial in insulin‐resistant states, particularly as AMPK activation also reduces cytokine secretion in adipocytes.
Understanding adjustment to disfigurement: the role of the self-concept

The objective of this study was to determine whether variation in psychological adjustment to physically disfiguring conditions is related to organisation of the content of appearance-related information in the self-concept. A cross-sectional design was employed, using 70 participants with a range of appearance problems recruited from support groups and the NHS. A postal paper and pencil task was completed by participants which assessed the level of their adjustment using the Derriford Appearance Scale, and measured the three self-concept variables – differential importance, compartmentalisation and complexity. Regression analyses showed that poor adjustment to disfigurement is related to greater differential importance of appearance-related self-aspects, greater compartmentalisation of appearance-related information and greater self-concept complexity. No moderating effects were found between these independent variables. The results have implications for psychological treatment strategies, particularly cognitive behavioural therapeutic interventions.
Stress before and after the 2002 Denali fault earthquake

Spatially averaged, absolute deviatoric stress tensors along the faults ruptured during the 2002 Denali fault earthquake, both before and after the event, are derived, using a new method, from estimates of the orientations of the principal stresses and the stress change associated with the earthquake. Stresses are estimated in three regions along the Denali fault, one of which also includes the Susitna Glacier fault, and one region along the Totschunda fault. Estimates of the spatially averaged shear stress before the earthquake resolved onto the faults that ruptured during the event range from near 1 MPa to near 4 MPa. Shear stresses estimated along the faults in all these regions after the event are near zero (0 ± 1 MPa). These results suggest that deviatoric stresses averaged over a few tens of km along strike are low, and that the stress drop during the earthquake was complete or nearly so.
Inducible expression of ribosomal clindamycin resistance in Bacteroides vulgatus

The abilities of erythromycin and clindamycin to act as inducers of clindamycin resistance in the strain Bacteroides vulgatus RYC18F6 is evaluated in vivo (efficiency of plating of inhibitory clindamycin concentrations) and in vitro [efficiency of poly(U)-directed polypeptide synthesis by ribosomes]. Uninduced cells failed to grow during the first 72 h, even at a very low clindamycin concentration (0.1 microgram/ml); after induction with erythromycin or clindamycin, cells were able to form colonies at 32 micrograms/ml after 48 h. The in vitro polymerization test with B. vulgatus RYC18F6 ribosomes (S-30 extract) showed that ribosomes from uninduced cells were fully sensitive to the inhibitory effect of clindamycin. Ribosomes obtained from erythromycin- or clindamycin-induced cells presented a reduced sensitivity to clindamycin inhibition. These results show that resistance to clindamycin in B. vulgatus RYC18F6 is an inducible phenomenon involving a ribosomal modification, probably similar to that previously described for gram-positive bacteria.
Programming of Endocrine Mechanisms of Cardiovascular Control and Growth

Several epidemiologic studies have linked size at birth to health in adult life. One school of thought centers on the part that periconceptual or intrauterine events play in this relationship. The idea is that an event, or several events, during critical periods of development can program, or permanently alter, fetal physiology resulting in altered size at birth and subsequent adult disease, including that of the cardiovascular system. Maternal diet or body composition at the time of conception can influence placental development and subsequent transfer of nutrients and substrates to the fetus. Alterations to the maternal diet or body composition throughout gestation are then seen as challenges that are superimposed on this backdrop of periconceptual events. One task is to find an animal model that replicates the major features of the epidemiologic data:for adult cardiovascular disease this would be alteredfetal size and the development of postniatal hypertension. In addition, a critical issue is to investigate the mechanisms underlying this Fetal Origins of Adult Disease hypothesis. The multiple mechanisms that constitutefetal cardiovascular responses to hypoxia in lategestation at neuronal, endocrine, and local tissue levels have been studied extensively, and there is evidence from several diferent experimental paradigms that these control mechanisms can be progranmmed by intrauterine challenges. This review synthesizes the current knowledge in this area and considers how the programming of cardiovascular control relates to fetal growth.
Functional organization of the brain with malformations of cortical development

We examined the localization of cerebral functions in 28 patients with focal epilepsy and malformations of cortical development (MCDs). Polymicrogyria occurred in nine, hemimegalencephaly in four, heterotopia in eight, and focal cortical dysplasia (FCD) in nine cases. We used simple (sensomotor, visual) or complex (language, memory) functional magnetic resonance imaging (fMRI) paradigms. Two thirds of MCDs were activated by simple fMRI paradigms, whereas they less frequently showed activity during complex cognitive fMRI paradigms. During simple paradigms, all disturbances of cortical organization (polymicrogyria, schizencephaly, and mild‐type FCD) showed activity, whereas other MCDs (disturbances of earlier steps of cortical development: hemimegalencephaly, Taylor‐type FCD, and heterotopia) showed activity in only 44% (p < 0.01). The association between the pathophysiology and morphology of MCDs confirms the recently proposed classification system. Both focal neurological signs (p < 0.05) and focal electroencephalogram slowing (p < 0.05) independently correlated with MCD inactivity, confirming that fMRI showed neuronal functions of MCDs. Conclusively, fMRI visualizes the MCD functions and their relationship to the eloquent cortex, providing useful information before epilepsy surgery. Surgery of cortical organization disturbances should be cautiously performed because these malformations may participate to some degree in brain functions. Ann Neurol 2003;53:759–767
A photoelastic substrate technique for dynamic measurements of forces exerted by moving organisms

The forces produced by small moving organisms have been quantitatively measured by having the organisms move on a polymeric substrate which transduces the applied stress into an optical birefringence signal (photoelastic effect). The optical signal can be rigorously interpreted to give static force measurements, and by calibrating the substrate empirically, dynamic measurements are obtained. The technique measures stresses, forces applied to an area, so it is not possible to determine ultimate sensitivity of the technique for measurements of forces without regard to area. The technique is especially useful when small forces are exerted over very small areas as, for example, may be the situation with moving tissue cells. The technique is noninvasive, requires minimal equipment, and is easily performed on microscopes adapted for polarized light measurements. Gelatin has the highest sensitivity and adaptability as a photoelastic substrate.
Stop Using That: Expressing Definiteness in Korean

Definiteness is visibly expressed by definite articles in English, but some languages such as Korean lack this morphological exponent. However, speakers of such languages still mark definiteness in different ways. In this proposal, we lay out a study that examines the (re)assembly required by L1-English L2-Korean learners where the formal feature of definiteness in the L1 has to be readjusted to indirect expressions in the L2. In particular, we propose to examine how L1-English learners distinctly interpret and produce the feature [definite] that has been coded overtly (demonstrative determiners) and covertly (word order change) in Korean. The participants’ use of demonstrative and word order will be examined by using elicited production tasks and forced-choice selection tasks. We predict that the participants will perform more accurately on the demonstratives. We further hope to gain insights into how much detection, mapping, and reassembly of the linguistic feature have progressed through the experiments.
Combined effects of oligofructose and Bifidobacterium animalis on gut microbiota and glycemia in obese rats

Prebiotics and probiotics may be able to modify an obesity‐associated gut microbiota. The aim of this study was to examine the individual and combined effects of the prebiotic oligofructose (OFS) and the probiotic Bifidobacterium animalis subsp. lactis BB‐12 (BB‐12) on gut microbiota and host metabolism in obese rats.
Oxygen Desaturation and Nursing Practices in Critically Ill Patients

Background: With the goal of optimizing tissue perfusion and maintaining adequate oxygen delivery, nurses play an important role in monitoring oxygenation and ventilation. Nursing practices may affect oxygen saturation in critically ill patients. Aim of study was to determine the relationship between nursing practices and oxygen desaturation in critically ill patients. Design: A descriptive research design was used in this study. Setting: The study was conducted at the Critical Care Units (CCUs) of two selected Hospitals at Makah AlMukaramah, KSA. Subjects; a convenience sample of 100 newly admitted critically ill patients were included in the study. Tool of data collection was the relationship between nursing practices and oxygen desaturation in critically ill patients’ tool. It consists of two parts: Part 1; nursing practices observation checklists and part 2; oxygen saturation monitoring record. Results: It was noted that in 67% of observations, patients had their position changed by nurses once per shift, no patients had hyperoxygenation during suctioning. In addition, there were significant correlation between oxygen desaturation during, and after bathing (r .403, p.000, r .342, p .000). Conclusion; nursing practices mainly suctioning, positioning and bathing affect oxygen desaturation in critically ill patients. There were significant relationships between oxygen desaturation and the procedures performed as oxygen saturation decreased during and after certain performed procedures especially suctioning. Recommendations: Protocols should be developed regarding oxygen desaturation in critically ill patients. Adequate supervision should be provided on nurses during their practice.
Frequency, associated factors, and treatment of breaststroker's knee in competitive swimmers

Thirty-six competitive breaststroke swimmers were in terviewed and examined for knee pain specifically re lated to the breaststroke kick. Eighty-six percent of the subjects had a history of at least one episode of breast stroke knee pain, while 47.2% had breaststroke knee pain that occurred at least once a week. There was a significant relationship between more frequent knee pain and increasing swimmer's age, increasing years of competitive swimming, increasing breaststroke train ing distance, and decreasing warm-up distance. The subjects with frequent knee pain were found to have less internal rotation at the hip joint. The most common site of breaststroke knee pain was the medial portion of the knee, with specific sites differing among the individuals. The medial synovial plica syndrome may be a cause of breaststroke knee pain, since 47% of subjects with weekly knee pain had tender, thickened medial plicae. Palpation of those pli cae produced pain similar to that experienced with the breaststroke kick. The findings in this study suggest that reducing or eliminating breaststroke training distance should be an initial measure in treatment. Applications of ice, changes in kick technique, stretching exercises to in crease hip rotation, and administration of aspirin may also be effective. The breaststroke training distance should be increased very gradually in the early season, and warm-up distance should be adequate to help prevent the symptoms of breaststroker's knee.
Calcitonin-negative neuroendocrine tumor of the thyroid: a distinct clinical entity.

BACKGROUND Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor (NET) that arises from the parafollicular cells (C-cells) of the thyroid gland which produces calcitonin (CT) and is, therefore, a serum and immunohistochemical biomarker of MTC. Here, we describe a patient with another form of NET arising with the thyroid gland. PATIENT FINDINGS This is a forty-year-old woman who underwent total thyroidectomy for a thyroid nodule that had features of an NET on fine needle aspiration. Her serum CT and carcinoembryonic antigen were normal. Surgical pathology showed a well-differentiated NET with immunohistochemical stains positive for markers of follicular cells (thyroglobulin and synaptophysin), positive for neuroendocrine markers (neuron specific enolase and chromogranin A), but negative for CT, the defining marker of MTC. CONCLUSIONS We describe a rare case of a nonmedullary NET of the thyroid gland arising from thyroid follicular cells, not parafollicular cells. We suggest that calcitonin-negative neuroendocrine tumor of the thyroid gland (CNNETT) may be an entity that has not been recognized in the literature. This distinction between MTC and CNNETT may be important, as the treatment and prognosis may differ.
Biokinetic food chain modeling of waterborne selenium pulses into aquatic food chains: Implications for water quality criteria

We evaluated the use of biokinetic models to predict selenium (Se) bioaccumulation into model food chains after short‐term pulses of selenate or selenite into water. Both periphyton‐ and phytoplankton‐based food chains were modeled, with Se trophically transferred to invertebrates and then to fish. Whole‐body fish Se concentrations were predicted based on 1) the background waterborne Se concentration, 2) the magnitude of the Se pulse, and 3) the duration of the Se pulse. The models were used to evaluate whether the US Environmental Protection Agency's (USEPA's) existing acute Se criteria and their recently proposed intermittent Se criteria would be protective of a whole‐body fish Se tissue‐based criterion of 8.1 μg g‐1 dry wt. Based on a background waterborne Se concentration of 1 μg L‐1 and pulse durations of 1 d and 4 d, the Se pulse concentrations predicted to result in a whole‐body fish Se concentration of 8.1 μg g‐1 dry wt in the most conservative model food chains were 144 and 35 μg L‐1, respectively, for selenate and 57 and 16 μg L‐1, respectively, for selenite. These concentrations fall within the range of various acute Se criteria recommended by the USEPA based on direct waterborne toxicity, suggesting that these criteria may not always be protective against bioaccumulation‐based toxicity that could occur after short‐term pulses. Regarding the USEPA's draft intermittent Se criteria, the biokinetic modeling indicates that they may be overly protective for selenate pulses but potentially underprotective for selenite pulses. Predictions of whole‐body fish Se concentrations were highly dependent on whether the food chain was periphyton‐ or phytoplankton‐based, because the latter had much greater Se uptake rate constants. Overall, biokinetic modeling provides an approach for developing acute Se criteria that are protective against bioaccumulation‐based toxicity after trophic transfer, and it is also a useful tool for evaluating averaging periods for chronic Se criteria. Integr Environ Assess Manag 2016;12:230–246. © 2015 SETAC