Miracle-dz/UniFAR-FTUs huggingface dataset:
Antidepressants and ABCB1 Gene C3435T Functional Polymorphism: A Naturalistic Study

Introduction: Pharmacogenetic factors may explain some of the interindividual variability of response to antidepressants in depressed patients. We focused on P-glycoprotein (P-GP), whose expression depends on a functional polymorphism of the ABCB1 gene (C3435T variants: dbSNP: rs1045642), the 3435CC genotype being linked to a high level of P-GP expression. Acting as an efflux pump at the blood-brain barrier, P-GP reduces the intracellular penetration of many drugs. Little is known about the interaction between P-GP and response to antidepressants. The objective of this study is to assess whether the response to antidepressants in depression differs in patients with the 3435CC genotype as compared to patients with the 3435CT and 3435TT genotypes. Methods: 117 in-patients with a major depressive episode requiring a new antidepressant treatment were enrolled in this prospective naturalistic 4-week study. Response to antidepressants was assessed using the Hamilton Depression Rating Scale, the Beck Depression Inventory, the Clinician Global Impression Improvement and Therapeutic Index, and weight change. ABCB1 genotyping was performed using the Taqman method. Clinical assessment was performed blind from genotypes. Results: We failed to show any significant effect of the ABCB1 polymorphism in position 3435 on antidepressant efficacy or tolerance. Discussion: While some in vitro studies showed an influence of P-GP on cerebral concentrations of antidepressants, our results do not support the hypothesis that the C3435T polymorphism is involved in therapeutic response and safety of antidepressants in naturalistic clinical conditions, confirming results of previous studies on efficacy. Nonetheless, some methodological limitations may explain our negative results.
Tumor necrosis factor‐α regulates secretion of the adipocyte‐derived cytokine, leptin

The seminal observation that secretion of the adipocyte‐derived hormone leptin was induced by inflammatory challenge has been expanded upon to demonstrate the importance of the pro‐inflammatory cytokines, especially tumor necrosis factor (TNF)‐α, in inflammatory hyperleptinemia. Initially, it was thought that cytokine‐induced hyperleptinemia might somehow be involved in the anorexia and cachexia that often accompany chronic infectious, neoplastic, and autoimmune disease. While the role of leptin in disease‐associated anorexia and cachexia appears tenuous in light of recent findings, there is evidence that the hyperleptinemia induced by cytokines is an integral part of the acute phase response and necessary for comprehensive immunocompetence. This hints at the existence of an integrated communication network, wherein the energy status of the animal impacts its ability to fight pathogens. Microsc. Res. Tech. 50:209–215, 2000. © 2000 Wiley‐Liss, Inc.
Effect of impact on chondrocyte viability during insertion of human osteochondral grafts.

BACKGROUND Osteochondral grafts, used to treat chondral and osteochondral defects, require high insertional forces that may affect the viability of chondrocytes in the graft. The objectives of this study were to (1) measure the loading impact during insertion of osteochondral grafts, (2) evaluate the effect of insertional loading on chondrocyte viability, and (3) assess this effect on chondrocyte apoptosis and activation of caspase-3. METHODS The distal parts of twelve fresh femora from six adult human cadavers were harvested within seventy-two hours after the death of the donor. From each femur, four 15-mm-diameter cylindrical osteochondral grafts were isolated; two of these grafts (a total of twenty-four grafts in the study) were transplanted with standard impact insertion into recipient sockets in the other condyle of the ipsilateral femur. The other two grafts served as unloaded controls. Loads were measured during the insertion of ten of the twenty-four transplanted grafts. Full-thickness cartilage disks were then removed from the grafts, incubated for up to forty-eight hours, and analyzed for cell viability, TUNEL (terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling)-positive reactivity, and caspase-3 activation, each as a function of the depth from the articular surface. RESULTS The insertion of an osteochondral graft was characterized, on the average (and standard deviation), by 10 +/- 4 impacts, each generating 2.4 +/- 0.9 kN of load and 13.3 +/- 4.9 MPa of stress for a duration of 0.57 +/- 0.13 ms with a 0.62 +/- 0.25 N.s impulse. Impact insertion increased cell death in the superficial 500 mum to 21% at one hour (p < 0.001) and 47% at forty-eight hours (p < 0.001) and also increased cell death in deeper layers at forty-eight hours. Some cell death was due to apoptosis, as indicated by an increase in caspase-3 activation at eight hours (p < 0.01) and TUNEL-positive cells at forty-eight hours (p < 0.05) in the superficial 500 mum of impacted cartilage. CONCLUSIONS Impact insertion of osteochondral grafts generates damaging loads that cause chondrocyte death, particularly in the superficial zone, mainly as a result of apoptosis mediated by the activation of caspases. CLINICAL RELEVANCE Chondrocyte death that occurs during impact insertion of osteochondral grafts may lead to compromised function. Understanding the mechanisms and consequences of such impact loading may provide insights into potential therapeutic interventions, or lead to changes in the insertion technique, to decrease the cell injury associated with impact loading.
N Demand and the Regulation of Nitrate Uptake

Uptake of nitrate by root cells followed by reduction and assimilation in plant tissues is the main route by which mineral N is converted into organic N by living organisms. Like photosynthesis, these are life-dependent processes that members of the animal kingdom are unable to perform for themselves. Nitrate and other mineral nutrients required for optimal plant growth and development frequently exist at relatively low concentrations in soil. To thrive on these dilute nutrients, plants have developed high-performance uptake systems in their root cells. To cope with wide variations in mineral concentrations in soil, plants have evolved mechanisms to regulate the activity of uptake systems so that net intake of a nutrient depends on the plant's need for this element rather than its concentration in the rooting medium. Indeed, uptake rates of most ions are seemingly controlled by specific demand-driven regulatory mechanisms. Such processes set the uptake rate of a given element to match the plant's current growth rate and developmental stage. Nitrate uptake is of special interest because nitrate is absorbed at a relatively high rate and because compounds that function as uptake sensors may have been identified. This paper focuses on whole-plant signaling processes involved in the regulation of nitrate uptake by N demand.
Low-frequency sound sources in high-speed turbulent jets

An analysis of the sound radiated by three turbulent, high-speed jets is conducted using Lighthill's acoustic analogy (Proc. R. Soc. Lond. A, vol. 211, 1952, p. 564). Computed by large eddy simulation the three jets operate at different conditions: a Mach 0.9 cold jet, a Mach 2.0 cold jet and a Mach 1.0 heated jet. The last two jets have the same jet velocity and differ only by temperature. None of the jets exhibit Mach wave characteristics. For these jets the comparison between the Lighthill-predicted sound and the directly computed sound is favourable for all jets and for the two angles (30° and 90°, measured from the downstream jet axis) considered. The momentum (ρuiuj) and the so-called entropy [p − p∞ − a∞2(ρ − ρ∞)] contributions are examined in the acoustic far field. It is found that significant phase cancellation exists between the momentum and entropy components. It is observed that for high-speed jets one cannot consider ρuiuj and (p′ − a∞2ρ′)δij as independent sources. In particular the ρ′ūxūx component of ρuiuj is strongly coupled with the entropy term as a consequence of compressibility and the high jet velocity and not because of a linear sound-generation mechanism. Further, in more usefully decoupling the momentum and entropic contributions, the decomposition of Tij due to Lilley (Tech. Rep. AGARD CP-131 1974) is preferred. Connections are made between the present results and the quieting of high-speed jets with heating.
Hidradenitis suppurativa: the role of immune dysregulation

Hidradenitis suppurativa (HS) is a chronic relapsing inflammatory disease of follicular occlusion characterized by boils, sinus tracts, fistulae, and scarring. It has a significant underestimated morbidity. Antimicrobial, immunosuppressive, anti‐androgenic, and surgical approaches have been used with varying results. Knowledge of the pathogenesis of HS is fragmented, and treatment choices have hitherto been empiric without an exact understanding of the scientific basis for their use. Tumor necrosis factor‐α inhibitors have shown promise in the treatment of HS in recent years, and the concept of HS as an immunological condition has come to the fore. The focus of this review is to discuss the immunological abnormalities underpinning HS as elucidated to date.
The Delivery of Pediatric Diabetes Care: Who is in Control?

Background: The morbidity and mortality associated with diabetes can be significantly reduced by timely and effective treatment. However, unless patients with diabetes have access to this treatment, and resources to utilize it, outcomes will not meet goals. We wanted to explore the impediments to effective care for the pediatric diabetes population. However, most studies evaluating diabetes care delivery have focused on the adult diabetes population, who tend to have different problems and a different constellation of providers. Evaluating the delivery of care for pediatric diabetes remains a challenging topic due to many medical, social, and economic factors. Methods: We began by surveying 100 families with diabetic children in our university practice, seeking their opinions about the delivery of diabetes care. In a confidential questionnaire, we asked about family demographics, family experiences relating to accessibility of care, freedom to choose facility, funding, and unmet healthcare needs. Results: Based on our pilot survey, it seems that families still have control in choosing a pediatric endocrinologist for diabetes care of their children. A reasonably high rate of second opinion visits suggests that families still have this choice. There is also evidence that physical distance to the practice is not a deterring factor from making clinic visits. Dissatisfaction with insurance companies’ understanding the funding that is needed for diabetes care of children has been also noted. The survey found a desire for psychological support of children with diabetes. Discussion: Based on this survey we can design a larger enquiry and suggest revisions in care design. It is very important to recognize and address psychological needs for family and children with diabetes. Finally, the multidisciplinary approval seems to be the key of success in providing diabetes care.
A Modified Neighborhood Similar Pixel Interpolator Approach for Removing Thick Clouds in Landsat Images

Thick-cloud contamination is a common problem in Landsat images, which limits their utilities in various land surface studies. This letter presents a new method for removing thick clouds based on a modified neighborhood similar pixel interpolator (NSPI) approach that was originally developed for filling gaps due to the Landsat ETM+ Scan Line Corrector (SLC)-off problem. The performance of the proposed method was evaluated with both simulated and real cloudy images and compared with that of a contextual multiple linear prediction (CMLP) method. The results show that the modified NSPI approach can greatly reduce the edge effects by CMLP. The reflectance restored by the modified NSPI approach is more accurate than that by CMLP, especially when the cloud-free auxiliary and cloudy images are acquired from different seasons and have different spectral characteristics.
Members’ Attendance Rates and Outcomes of Relationship Education Groups: A Consensus-Dispersion Analysis

Relationship education programs (REPs) are an effective way to enhance relationship communication, prevent relational distress, and increase relationship quality. Most REPs are delivered in a group format; however, there is little known about the influence of group processes on outcomes for these programs, such as group members’ attendance. Therefore, the current study applied a dispersion-consensus model to test the impact of attendance at the member and group levels on group members’ REP outcomes. In a sample of 558 lower income, primarily African American participants, we examined whether individual and group attendance rates influenced posttreatment communication patterns and relationship quality. Results indicated that an individual group member’s attendance was significantly and positively related to their posttreatment relationship quality, although this relationship is complex. Specifically, this relationship was stronger in groups with higher levels of attendance as well as groups with more attendance variability. In addition, results indicated that group members reported better posttreatment relationship quality in groups with less variability in members’ attendance. However, we found a significant interaction between attendance consensus and variability, and an individual group member’s posttreatment relationship quality, suggesting that group members report higher levels of relationship quality in groups where the attendance of the group as a whole is lower yet more consistent. No significant relationships were found for group member’s posttreatment communication patterns. Our findings suggest that the rate and variability in the group’s attendance, as well as an individual group member’s own attendance significantly impacts their posttreatment relationship quality in complex ways.
Cardiac Arrest Survival Is Rare Without Prehospital Return of Spontaneous Circulation

Abstract Background. Emergency medical services (EMS) are crucial in the management of out-of-hospital cardiac arrest (OHCA). Despite accepted termination-of-resuscitation criteria, many patients are transported to the hospital without achieving field return of spontaneous circulation (ROSC). Objective. We examine field ROSC influence on OHCA survival to hospital discharge in two large urban EMS systems. Methods. A retrospective analysis of prospectively collected data was conducted. Data collection is a component of San Antonio Fire Department's comprehensive quality assurance/quality improvement program and Cincinnati Fire Department's participation in the Cardiac Arrest Registry to Enhance Survival (CARES) project. Attempted resuscitations of medical OHCA and cardiac OHCA for San Antonio and Cincinnati, respectively, from 2008 to 2010 were analyzed by city and in aggregate. Results. A total of 2,483 resuscitation attempts were evaluated. Age and gender distributions were similar between cities, but ethnic profiles differed. Cincinnati had 17% (p = 0.002) more patients with an initial shockable rhythm and was more likely to initiate transport before field ROSC. Overall survival to hospital discharge was 165 of 2,483 (6.6%). More than one-third (894 of 2,483, 36%) achieved field ROSC. Survival with field ROSC was 17.2% (154 of 894) and without field ROSC was 0.69% (11 of 1,589). Of the 11 survivors transported prior to field ROSC, nine received defibrillation by EMS. No asystolic patient survived to hospital discharge without field ROSC. Conclusion. Survival to hospital discharge after OHCA is rare without field ROSC. Resuscitation efforts should focus on achieving field ROSC. Transport should be reserved for patients with field ROSC or a shockable rhythm.
Sensorineural hearing loss in patients with large vestibular aqueduct

In examining 181 patients (327 ears) with sensorineural hearing loss of unknown etiology and 25 people (50 ears) with normal hearing by high‐resolution computed tomography (CT), the image of the large vestibular aqueduct (VA) was defined as being a visible large aperture (≥4 mm), and small distance between vestibule and traceable part of the VA nearest to the vestibule (≥1 mm). The large VA was found in 13 patients (23 ears, 7.0%); it was relatively frequent following hypoplastic cochlea (33 ears, 10.1%) in all the inner ear anomalies detected. In patients with large VA, high‐frequency hearing was affected more than low frequency, and history of sudden hearing loss was observed frequently (61% of ears with large VA), which was found to be triggered by characteristic episodes such as minor head trauma, etc. Those clinical features were observed more in those without cochlear anomaly than in those accompanying cochlear anomaly. Pathogenesis of sensorineural hearing loss and characteristic fluctuation of hearing in those patients are discussed.
Influence of vitamin D receptor genotype on bone mineral density in postmenopausal women: a twin study in Britain

Abstract Objectives: To investigate the possible association between vitamin D receptor genotype and bone mineral density in a large group of postmenopausal twins. Design: Cross sectional twin study. Setting: Twin population based in Britain. Subjects: 95 dizygotic (non-identical) pairs of twins and 87 monozygotic (identical) pairs of twins aged 50-69 years, postmenopausal, and free of diseases affecting bone, recruited from a national register of twins and with a media campaign. Main outcome measures: Bone mineral density measured at the hip, lumbar spine, forearm, and for the whole body by dual energy x ray absorptiometry in relation to differences in the vitamin D receptor genotype. Results: At all sites the values of bone density among dizygotic twins were more similar in those of the same vitamin D receptor genotype than in those of differing genotype, and the values in the former were closer to the correlations seen in monozygotic twins. Women with the genotype that made them at risk of osteoporotic fracture had an adjusted bone mineral density that was significantly lower by SD 0.5 to 0.6 at the hip, lumbar spine, and for the whole body. The results could not be explained by differences in age, weight, years since menopause, or use of hormone replacement therapy. Conclusions: The findings that in postmenopausal women in Britain bone density—particularly at the hip and spine—is genetically linked and specifically associated with the vitamin D receptor genotypes should lead to novel approaches to the prevention and treatment of osteoporosis. Key messages Key messages Vitamin D has an important role in the metabolism of calcium and bone, mediated through its receptor Common variants of the vitamin D receptor gene are responsible for 7-10% of the difference in bone density between women after the menopause This genetic marker is important because of its potential role in identifying individual women at increased risk of fracture before menopause and in selecting optimal treatment
The circumstances of falls among people with Parkinson's disease and the use of Falls Diaries to facilitate reporting

Purpose. Falls are common in Parkinson's disease (PD). Falls Diaries are one way of recording fall frequency and the surrounding circumstances; completing them encourages recall, and their content focuses intervention. We reviewed the diaries completed by people with PD during a randomized controlled trial (RCT) of fall prevention to ascertain the key circumstances surrounding falls. Method. We asked independently mobile, cognitively intact people with a diagnosis of PD to maintain a Falls Diary throughout a six-month RCT. We sent monthly diary sheets on which to answer questions about the ‘Location’, ‘Fall-related activity’, ‘Perceived cause’, ‘Landing’ and ‘Consequences’ of every fall. We coded responses and counted frequencies. Results. Of the 142 RCT participants (mean age 72 years; mean years since diagnosis 8), 135 completed the trial and their diary. We excluded 11 (8%) for missing data and/or unintelligible writing. The 124 remaining diaries recorded 639 falls: 80% happened at home, commonly in bedrooms, living areas, kitchens and gardens. Fallers had been ambulant in 45% of events, standing in 32% and transferring in 21%. Six ‘activity-cause combinations’ accounted for 55% of falls (tripping 13%; freezing, festination and retropulsion 11%; and postural instability when bending or reaching 9%, transferring 8%, walking 7% and washing or dressing 7%). Misjudgement and distraction played a part in 12% of falls described. Conclusions. Of over 600 falls surveyed, most happened at home, provoked by postural instability, tripping and freezing. Environmental adaptation and cognitive training should be trialled in falls prevention in PD, plus or minus traditional movement rehabilitation. Most participants completed Falls Diaries successfully. We advocate diary use, with follow-up interviews, in research and clinically. People with handwriting difficulty may require a typed diary, proxy diarist or interview.
Practices of place-making through locative media artworks

Abstract In recent years, the vast increase in information flows has made it possible to instantly connect location-dependent information with physical spaces. These technologies have provided new forms of the representation of space as much as new forms of perception through tools and techniques used in land surveying, remote sensing, etc. From a critical point of view, pervasive computing, location-based applications, or, in other words, “locative media” provide an interesting framework to understand how these technologies relate to our understanding of space and place. Concretely, we want to examine how the uses of locative media in social-oriented artworks interact with people's sense of place. This article therefore discusses contemporary theories on space related to media and technology with a specific focus on the conceptualization of the notion of place. It also relates these theories to the study of different locative media artworks: Canal Accessible (2006), Bio Mapping (2004), Disappearing Places (2007), and Coffee Deposits (2010). We contend that locative media artworks act upon distinctive ways to understand the mediation of technology in current place-making practices.
Recipient and Donor Body Mass Index as Important Risk Factors for Delayed Kidney Graft Function

Background. Obesity is increasingly impacting the overall health status and the global costs for health care. The increase in body mass index (BMI) is also observed in kidney allograft recipients and deceased organ donors. Methods. In a retrospective single-center study, we analyzed 1132 deceased donor kidney grafts, transplanted at our institution between 2000 and 2009 for recipient and donor BMI and its correlation with delayed graft function (DGF). Recipients/donors were classified according to their BMI (<18.5, 18.5–24.9, 25–29.9, and >30 kg/m2). DGF was defined as requirement for one dialysis within the first week after transplantation. Results. Overall DGF rate was 32.4%, mean recipient BMI was 23.64±3.75 kg/m2, and mean donor BMI was 24.69±3.44 kg/m2. DGF rate was 25.2%, 29.8%, 40.9%, and 52.6% in recipients with BMI less than 18.5, 18.5 to 24.9, 25 to 29.9, and more than 30 kg/m2, respectively (P<0.0001). Donor BMI less than 18.5, 18.5 to 24.9, 25 to 29.9, more than 30 kg/m2 resulted in a DGF rate of 22.5%, 31.0%, 37.3%, and 51.2% (P<0.0001). Multivariate analysis revealed recipient BMI and dialysis duration as independent risk factors for DGF. DGF results in inferior 1- and 5-year graft and patient survival. Conclusion. Recipient and donor BMI correlate with the incidence of DGF. Awareness thereof should have an impact on peri- and posttransplant measures in renal transplant recipients.