Miracle-dz/UniFAR-FTUs huggingface dataset:
Chloride intracellular channel 1 regulates prostate cancer cell proliferation and migration through the MAPK/ERK pathway.

UNLABELLED Abstract Aims: To investigate the effect of chloride intracellular channel 1 (CLIC1) on the proliferation, migration, and apoptosis of prostate cancer cell lines PC-3 and DU145 and the possible molecular mechanisms. MATERIALS AND METHODS Using the technique of RNA interference, the expression of CLIC1 was downregulated in the PC-3 and DU145 cell lines. MTT assay, Transwell chamber, and flow cytometry were used to determine the effect of CLIC1 on the proliferation, migration, and apoptosis ability of PC-3 and DU145 cells. The levels of phosphorylated extracellular signal-regulated kinase 1/2 (p-ERK1/2), ERK1/2, matrix metalloproteinase (MMP)-2, and MMP-9 were examined by western blotting. RESULTS The results showed that the knockdown of CLIC1 exerts inhibitory effects on the proliferation and migration of PC-3 and DU145 cells. At the same time, the authors found that the knockdown of CLIC1 has no effect on the apoptosis in PC-3 and DU145 cells. Meanwhile, the levels of p-ERK1/2, MMP-2, and MMP-9 were decreased in the CLIC1 small interfering RNA (siRNA) group compared with the control and vector groups. CONCLUSION These results indicate that CLIC1 could regulate prostate cancer cell proliferation and migration by regulating the mitogen-activated protein kinase (MAPK)/ERK pathway and offers a candidate molecular target for prostate cancer prevention and therapy.
THE ECOLOGY OF GREEN SEA TURTLES

Many green sea turtle populations are slowly recuperating from a recent severe decline due to anthropogenic factors including human consumption and mortality related to the fishing industry. Despite being charismatic animals that have been extensively studied, there is still a limited understanding of their feeding strategies and diet plasticity. This research explores the use of hydrogen isotopes in marine ecosystems to better understand green sea turtle ecology. This study is presented in two chapters: I first examined the trophic discrimination factor (D2HNET) for hydrogen isotope (d2H) as a tool to correct hydrogen isotope data for wild populations, and next explored the use of hydrogen isotopes in conjunction with nitrogen and carbon isotopes to study green sea turtle diet and habitat use in Baja California Sur. Together, this research was used to (a) differentiate feeding strategies and habitat use for wild green sea turtles living in different habitats (open ocean versus lagoon) along the Pacific coast of Baja California Sur and (b) determine the utility of hydrogen isotopes to trace regional migration and trophic level patterns in wild sea turtle populations. Results from these studies provide additional evidence of wide feeding plasticity in green sea turtles as has been reported in previous
Recent results on structure functions

Significant progress has been made in recent years in both unpolarized structure functions of the nucleon as well as polarized structure functions. More recently, both experimental and theoretical studies of the structure of the nucleon have advanced beyond the one-dimensional collinear approximation, and three-dimensional descriptions of the nucleon structure both in momentum space, and longitudinal momentum-transverse space are becoming active areas of research. In this talk, I will review recent results on structure functions of the nucleon.
An Analysis of the Determinants of Corporate Social Responsibilty of Brazilian Firms

This work makes an analysis of the determinants of Corporate Social Responsibility (CSR) of Brazilian firms, as proxied by firm membership of the ISE Index of BM&FBOVESPA. Besides other proposed determinants of CSR present in the literature (firm size, profitability, growth opportunities), the work examines ownership concentration and the persistence on CSR status. Logit regression estimates have been run for a sample of 1649 firm-year observations in the period 2006-2011. The findings show that CSR of Brazilian firms is inversely correlated to its ownership concentration indicating that controlling voting shareholders may not see social concerns as a priority. Besides, firms tend to maintain their present CSR status. The results also indicate that leading CSR firms are larger, face more growth opportunities, and are persistent in their superior CSR situation.
MUTAGENIC STRAIN IMPROVEMENT OF ASPERGILLUS NIGER ( MBL-1511 ) AND OPTIMIZATION OF CULTURAL CONDITIONS FOR BOOSTED LIPOLYTIC POTENTIAL THROUGH SUBMERGED FERMENTATION

In present study an isolated hyper producer of Aspergillus niger (MBL-1511) was treated for sodium azide mutagenesis. Results showed 147.27 % enhanced extracellular lipase activity after 150 minutes of sodium azide treatment. Wild and mutant hyper lipase producer strains were exploited to submerged fermentation (SmF). Brassica meal as an additive agro waste product to the basal medium was optimized. Experimental conditions optima were 10% inoculum size, 30C temperature, 96 h rate of fermentation and pH 6 for maximum lipases production. Molasses and Ammonium nitrate were optimized as the best carbon and nitrogen sources (0.6% and 0.4%) w/v respectively and sunflower oil 1% (v/v) as better inducer. Finally, an effective mutant [MBL-1511(150 min)] having of 176.10% enhanced extracellular lipases production over wild (MBL-1511) strain was acquired.
Accuracy of genomic selection in dual purpose Fleckvieh cattle using three types of methods and phenotypes

Genomic selection (Meuwissen et al. (2001)) predict s breeding values estimated from effects of genome wide dense genetic markers to select youn g bulls. The development of high throughput genotyping of many thousands of single n ucleotide polymorphisms (SNPs) enabled the rapid implementation of genomic selecti on in cattle breeding programs. An Interbull survey on genomic selection reported a va riety of methods and phenotypes that are being used in genomic predictions all around the wo rld (Loberg and Dürr (2009)). In this study we compared conventional breeding values, deregressed breeding values, and daughter yield deviations as phenotypes using three diff rent methods to predict direct genomic breeding values for one production and two fertility traits in the Fleckvieh breed.
Agoraphobia and Interpersonal Relationships: Theory and Research

The present study examined the quality of the marital relationships of agoraphobic individuals as compared to a sample of nonclinical subjects. Comparisons between the agoraphobic group and the control group were also made on one’s gender-role concept and the degree of interpersonal dependency on others. Forty-six agoraphobic subjects and 50 nonclinical control subjects completed self-report measures. Interpersonal dependency was assessed using the Interpersonal Dependence Inventory's three subscales: emotional reliance on others, lack of self-confidence, and assertion of autonomy. Quality of the significant relationship was measured with the Quality of Relationships Inventory subscales that assess the degree of social support from significant other, amount of conflict in relationship, and depth of significant relationship. The Personal Attributes Questionnaire evaluated gender-role stereotyping in subjects' selfconcept with scales of Agency (masculinity) and Communion (femininity). Multivariate and univariate analyses indicated significantly higher scores for the agoraphobic group on emotional reliance on others, £(1,70) = 15.22, £<. 001. The mean score for selfconfidence was significantly lower for the agoraphobic group, £(1,70) = 22.97, £<. 001. The agoraphobic group's mean Agency (masculinity) score was significantly lower than the control group's score, £(1,70) = 14.85, £<. 001. Agoraphobic subjects' mean score for social support from significant other was significantly lower, £(1,70) = 17.862, £<. 001. Agoraphobic subjects had a significantly higher mean score on level of conflict in the significant relationship, £(1,70) = 26.672, £<. 001. The agoraphobic group scored significantly lower on depth of the significant relationship, £(1,70) = 4.542, £<. 05. These results support spousal involvement in treatment programs for agoraphobia, and demonstrate gender role perspectives and personality characteristics that need to be addressed when treating the agoraphobic individual.
SME development strategy and product/service innovation intention: A NCaRBS analysis of the role of uncertainty

Small and medium-sized enterprises (SME) are tasked with driving economic recovery globally, in terms of contribution to economic growth. Understanding the determinants of SME innovation is essential in clarifying this phenomena. This study investigates the link between SME strategies and intention to undertake future innovation, using Federation of Small Businesses data. The analysis employs the novel N-State Classification and Ranking Belief Simplex (NCaRBS) technique, investigating relationships between changes in SME strategies, including staffing levels, importing/exporting and client base, and future (including uncertain) innovation intentions. NCaRBS can analyse an incomplete data set, with missing values in the considered characteristic variables, without the need to manage their presence. NCaRBS can also generate results providing insights into SME behaviour regarding strategy and innovation, while also increasing learning about potential reasons behind SMEs uncertainty regarding innovation intention. The study provides novel perspectives into how SMEs develop innovation intentions and the strategies required to support/exploit such intentions, of value to academia, enterprise support agencies and policymakers.
Forward Neutral-Pion Transverse Single-Spin Asymmetries in p þ p Collisions at 200 GeV

We report precision measurements of the Feynman x ( x F ) dependence, and ﬁrst measurements of the transverse momentum ( p T ) dependence, of transverse single-spin asymmetries for the production of (cid:1) 0 mesons from polarized proton collisions at ﬃﬃﬃ s p ¼ 200 GeV . The x F dependence of the results is in fair agreement with perturbative QCD model calculations that identify orbital motion of quarks and gluons within the proton as the origin of the spin effects. Results for the p T dependence at ﬁxed x F are not consistent with these same perturbative QCD-based calculations.
On the origin of the Norwegian lemming

The Pleistocene glacial cycles resulted in significant changes in species distributions, and it has been discussed whether this caused increased rates of population divergence and speciation. One species that is likely to have evolved during the Pleistocene is the Norwegian lemming (Lemmus lemmus). However, the origin of this species, both in terms of when and from what ancestral taxon it evolved, has been difficult to ascertain. Here, we use ancient DNA recovered from lemming remains from a series of Late Pleistocene and Holocene sites to explore the species' evolutionary history. The results revealed considerable genetic differentiation between glacial and contemporary samples. Moreover, the analyses provided strong support for a divergence time prior to the Last Glacial Maximum (LGM), therefore likely ruling out a postglacial colonization of Scandinavia. Consequently, it appears that the Norwegian lemming evolved from a small population that survived the LGM in an ice‐free Scandinavian refugium.
SIMULATION OF A PORTUGUESE LIMESTONE MASONRY STRUCTURE SUBMITTED TO FIRE: 3D ULTRASONIC TOMOGRAPHY APPROACH

A multianalytical approach combining 3D ultrasonic tomography, FESEM, capillary absorption coefficient, open porosity and elastic constants (σ, E, μ and K) has been applied to characterize the extent and severity of Lioz limestone decay processes induced by fire, as well as the performance of two consolidants (ethyl silicate and nanolime). Samples (15 cm × 3 cm × 3 cm) were partially buried in fine sand (to mimic the real situation of stone blocks in masonry structures) and a section of 15 cm × 3 cm × 0.5 cm was exposed to direct heat (600oC). The region directly exposed to heat exhibited lower P-wave velocity and more intense fissuration whereas the areas more protected showed thermal etch pits structures. Ethyl silicate showed better performance than nanolime and 3D ultrasonic tomography allowed estimating the depth reached by this consolidant.
Incidence of mycotic gastritis in calves up to 30 days of age.

MYCOTIC GASTRITIS in the bovine species has been described primarily in animals over 30 days of age (1, 4, 9, 10, 14, 18, 19, 20). There are few reports of the condition in nursing calves younger than 30 days of age; the most common causative agents incriminated in such young calves are Candida albicans (3, 9, 12, 13, 21) and phycomycetes (1, 6). The purpose of this study was to determine the incidence of mycotic gastritis in young calves submitted for necropsy to the Department of Veterinary Pathology, Western College of Veterinary Medicine, Saskatoon, Saskatchewan, Canada, from July 1, 1971 to June 30, 1972. Causes of death other than mycotic gastritis are briefly reported as well, in order to provide the necessary background information.
Biological Suppression of Coconut Black Headed Caterpillar Opisina arenosella Outbreak in East Godavari District of Andhra Pradesh-Eco Friendly Technology

The leaf eating black headed caterpillar Opisina are­ nosella is a serious pest of coconut palm causing significant yield I ss in aU the coconut growing tracts of India. Du.ring 2015-16, a high infestation of black headed caterpiUar was observed in all the coastal dis­ tricts of Andhra Pradesh, and an incidence ranging froD 42.82% to 62.86% was recorded. From October 2015 to April 201 6 inundative releases of about 3,788,000 larval parasitoids Bracon hebetor and Goni­ ozus neph(l1Itidis were carried out in pest affected gar­ dens in Allavaram and Uppalaguptam mandals of East Godavari. To study the impact of the parasitoid releases, 10 leaflets/palm were randomly collected from ·10 sample gardens in seven villages of these mandals and the pest population recorded. After three months of parasitoid release, the larval population of O. arenosella decreased by 34.08-75.88%, pupal popu­ lation 'Jy 33.33-94.52%, and the paralysed larval pop­ ulation recovered was 8.30-26.92%. After six months, the larval population decreased by 59.65-100%, the pupal population up to 92.77-100% and the paralysed larval population recovery was also high, ranging from 18.68% to 34.61 % . The impact of inundative release of bio agents for suppression of le.af eating caterpillar was prominent, after six months providing impetus to the role of biological control in pest man­ agement. The assumed overall economic loss prevented due to this intervention was 192.6 million rupees.
The Role and Perspectives of Administrators in the Schools of Orang Asli Students : A Case Study in the State of Pahang

This study discusses the role and perspectives of administrators towards the schools and education of ‘Orang Asli’ (Original People) students. This case study was carried out regarding to the problems related to the role played by school administrators that give implications for the quality of Orang Asli education. Two primary school administrators involved in the semi-structured interview to answer the focused questions on seven modified aspects of GPILSEO Model. The interview was audio-taped, transcribed and checked for content based on predetermined themes. The findings showed that school administrators have moderate targets in improving the achievements of Orang Asli students, encouraging fun method of teaching and learning, and stated the equipments needed by the school were sufficient but in a sorry state. The findings also showed they carried out assessments for teachers and students as scheduled and helped to distribute assistance from government in the forms of money and materials to the students. The final finding showed that the school administrators and their teacher were highly committed in managing the school of Orang Asli. This gives a major implication that the school administrators should play a role as an agent planning to increase the achievement of Orang Asli students in education.
EXPERIMENTAL STUDY ON WEAR OF MIXED CERAMIC TOOL AND CORRELATION ANALYSIS BETWEEN SURFACE ROUGHNESS AND CUTTING TOOL RADIAL VIBRATIONS DURING HARD TURNING OF AISI 52100 STEEL

Wear investigation has been conducted on mixed ceramic cutting tool (70% Al2O3 + 30% TiC) when machining hardened AISI 52100 steel (66 HRC). Experimental planning method has been used to assess the relationship between radial cutting vibrations and surface roughness as a function of the machining conditions. First, wear results show that when the cutting speed is increased 3.78 times, tool life drops of 8.75 times. When increasing the feed rate by a factor of 2.75 tool life decreases by a factor of 1.4. Then, the effect of cutting parameters (speed, feed and depth) on one hand surface roughness (Ra) and in the other hand radial tool vibrations has been determined using the multiple regression models with a coefficient of determination R2 equal to respectively 95.5% and 89.3%. With regards to surface roughness, ANOVA analyses reveal that feed rate contributes of about 84% in the surface roughness. Meanwhile, looking at the vibration phenomena, the cutting speed has the most significant effect on the values of radial tool vibrations comparing to depth and feed rate effect. Finally the correlation between surface roughness and tool radial vibrations has been analyzed through the linear and nonlinear correlation coefficients. The values of Pearson and Spearman coefficient were respectively low 0.465 and 0.554 showing that above 1000 rpm of cutting speed, the machining system is no more stable generating a great effect of cutting vibrations.
A Preliminary Survey on Awareness of Periodontal Risk and Oral Health Practices among Diabetic Patients in Hospital Kuala

Aim. To determine the level of awareness on periodontal disease risk andthe oral health practice among diabetic patients in Hospital Kuala Lumpur and the source of information they receive regarding the periodontal risk among diabetic patients. Materials and Methods. This cross-sectional study was conducted among confirmed diabetic patients (n=110) through convenient sampling at the Specialist Medical Clinic and Out-patient Department of Hospital Kuala Lumpur. A selfadministered questionnaire was constructed incorporating tenitems related to sociodemographic data, awareness on periodontal risk and the need for good oral health care.Sources of information regarding periodontal disease risk and their oral health practice were also included. Results. The response rate for this study was high (93%). Only 26.5% and 19.6% of respondents were aware of the risk of developing periodontal disease and the need for good oral health practice among diabetic patientsrespectively. Less than a third (25.9%) of the respondent claimed to obtain the information on periodontal risk from their dentists.Eighty percent of patients brushed twice or more a day and only 7% of themused floss for interdental cleaningOne thirdof respondents visited their dentists for the last 1-2 years. There was asignificantly higher proportion of regular attendees who were aware of periodontal risk amongst diabetics as compared to irregular attendees (p<0.05). Conclusion. Level of awareness on periodontal disease risk and the need for good oral health care was low among diabetics.Eventhough good toothbrushing frequency was found, the importance of interdental cleaning must be emphasized to diabetic patients. Dentistsshould play more active roles in informing diabetic patients of their periodontal risk and the needs for good oral health practice.
Postoperative Telemonitoring Following Kidney Transplantation : Effects on Early Hospital Readmissions and Graft Outcomes

Background: Telemonitoring has been recently shown to improve outcomes and reduce hospital admission rate in cardiac patients. Effect of telemonitoring on early hospital readmission and graft outcomes in kidney transplant population is not well studied. Methods: In this retrospective observational study, we compared 167 kidney transplant recipients who were discharged with telemonitoring to 191 historic controls with no telemonitoring. All telemonitored patients were monitored with the use of CardioCom device, by a registered nurse trained in transplant and home care. To assess the impact of the telemonitoring on readmission rate, logistic regression analysis was performed. Survival analysis was conducted to assess impact on one-year graft and patient survival. Results: Of 358 total patients, 32.1% (n=115) had early readmission. Of these, 56 of the 167 patients (33.5%) with telemonitoring experienced early readmission, compared to 59 of 191 controls (30.9%). Telemonitoring was associated with slightly higher early readmission compared to control group, which was not statistically significant (OR=1.13, 95% CI=0.72-1.76, p=0.59). Telemonitored and control patients had comparable one-year graft and patient survival, 97% vs. 94.2% (HR: 0.51; 95 CI: 0.18-1.48, p=0.22) and 98% vs. 96.3% (HR: 0.32; 95 CI: 0.07-1.55, p=0.14) respectively. Conclusions: Early post kidney transplant telemonitoring did not show significant reduction in early hospital admission rate or improvement in 1-year patient/ graft survival.
Hospital-based palliative care consultation: effects on hospital cost.

CONTEXT Palliative care consultation teams in hospitals are becoming increasingly more common. Palliative care improves the quality of hospital care for patients with advanced disease. Less is known about its effects on hospital costs. OBJECTIVE To evaluate the relationship between palliative care consultation and hospital costs in patients with advanced disease. DESIGN, SETTING, AND PATIENTS An observational study of 3321 veterans hospitalized with advanced disease between October 1, 2004 and September 30, 2006. The sample includes 606 (18%) veterans who received palliative care and 2715 (82%) who received usual hospital care. October 1, 2004 and September 30, 2006. MAIN OUTCOME MEASURES We studied the costs and intensive care unit (ICU) use of palliative versus usual care for patients in five Veterans Affairs hospitals over a 2-year period. We used an instrumental variable approach to control for unmeasured characteristics that affect both treatment and outcome. RESULTS The average daily total direct hospital costs were $464 a day lower for the 606 patients receiving palliative compared to the 2715 receiving usual care (p < 0.001). Palliative care patients were 43.7 percentage points less likely to be admitted to ICU during the hospitalization than usual care patients (p < 0.001). COMMENTS Palliative care for patients hospitalized with advanced disease results in lower costs of care and less utilization of intensive care compared to similar patients receiving usual care. Selection on unobserved characteristics plays an important role in the determination of costs of care.