Miracle-dz/UniFAR-FTUs huggingface dataset:
Organoids from colorectal peritoneal metastases as a platform for improving hyperthermic intraperitoneal chemotherapy

Patients with peritoneal metastases from colorectal cancer have a poor prognosis. If the intraperitoneal tumour load is limited, patients may be eligible for cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy (HIPEC). This treatment has improved overall survival, but recurrence rates are high. The aim of this study was to create a preclinical platform for the development of more effective intraperitoneal chemotherapy strategies.
An Ideological and Cultural Study of Taboo Terms Translation in English- Persian Dubbed Movies by IRIB

In our modern life, the introduction of new technologies and subsequent boom in satellites, television, as well as the Internet has made the world a much smaller place allowing different nations, cultures, and languages to interact more frequently. One of the biggest concerns of audiovisual translators is cultural and ideological items which taboo terms are included. This study aims at investigating the strategies applied in the translation of taboo terms, from English into Persian, in five dubbed Hollywood movies broadcast by Islamic Republic of Iran Broadcasting. The original movies were compared with their dubbed Persian versions based on Sharifi and Darchinian’s (2009) strategies. The “Censorship” strategy is the topmost used strategy in the rendition of the taboos with the highest frequency (56%). The second frequent strategy is “Taboo to Taboo” which involves 19%, the third frequent strategy is “Euphemism” with 13%, and the least frequent strategy for dealing with taboos is “Taboo to Non-Taboo” which is 12%. The results of the present study show that considering ideological and cultural aspects of the society, Iranian AV translators attempted to moderate and soften the original taboo terms, which would be considered as taboo by the cultural standards of the Iranian audiences.
Complex Relationships Among Personality Traits, Job Characteristics, and Work Behaviors

The aim of the study was to investigate the additive, mediating, and moderating effects of personality traits and job characteristics on work behaviors. Job applicants (N 5161) completed personality questionnaires measuring extraversion, neuroticism, achievement motivation, and experience seeking. One and a half years later, supervisors rated the applicants’ job performance, and the job incumbents completed questionnaires about skill variety, autonomy, and feedback, work stress, job satisfaction, work self-efficacy, and propensity to leave. LISREL was used to test 15 hypotheses. Perceived feedback mediated the relationship between achievement motivation and job performance. Extraversion predicted work self-efficacy and job satisfaction. Work stress mediated the relationship between neuroticism and job satisfaction. Job satisfaction and experience seeking were related to propensity to leave. Autonomy, skill variety, and feedback were related to job satisfaction.
Evolution and Medical Significance of LU Domain−Containing Proteins

Proteins containing Ly6/uPAR (LU) domains exhibit very diverse biological functions and have broad taxonomic distributions in eukaryotes. In general, they adopt a characteristic three-fingered folding topology with three long loops projecting from a disulfide-rich globular core. The majority of the members of this protein domain family contain only a single LU domain, which can be secreted, glycolipid anchored, or constitute the extracellular ligand binding domain of type-I membrane proteins. Nonetheless, a few proteins contain multiple LU domains, for example, the urokinase receptor uPAR, C4.4A, and Haldisin. In the current review, we will discuss evolutionary aspects of this protein domain family with special emphasis on variations in their consensus disulfide bond patterns. Furthermore, we will present selected cases where missense mutations in LU domain−containing proteins leads to dysfunctional proteins that are causally linked to genesis of human disease.
Antibodies Predict Pegaspargase Allergic Reactions and Failure of Rechallenge.

PURPOSE Pegaspargase (PEG-ASP) has largely replaced native Escherichia coli asparaginase (L-ASP) in the treatment of acute lymphoblastic leukemia because of its longer half-life and lower immunogenicity. Risk factors for allergic reactions to PEG-ASP remain unclear. Here, we identify risk factors for reactions in a front-line acute lymphoblastic leukemia trial and assess the usefulness of serum antibodies for diagnosing allergy and predicting rechallenge outcome. PATIENTS AND METHODS PEG-ASP was administered to 598 patients in St Jude's Total XVI study. Results were compared with Total XV study ( ClinicalTrials.gov identifiers: NCT00549848 and NCT00137111 ), which used native L-ASP. Serum samples (n = 5,369) were analyzed for anti-PEG-ASP immunoglobulin G by enzyme-linked immunosorbent assay. Positive samples were tested for anti-polyethylene glycol (PEG) and anti-L-ASP. We analyzed potential risk factors for reactions and associations between antibodies and reactions, rechallenge outcomes, and PEG-ASP pharmacokinetics. RESULTS Grade 2 to 4 reactions were less common in the Total XVI study with PEG-ASP (81 [13.5%] of 598) than in the Total XV study with L-ASP (169 [41.2%] of 410; P = 1.4 × 10-23). For Total XVI, anti-PEG, not anti-L-ASP, was the predominant component of anti-PEG-ASP antibodies (96%). In a multivariable analysis, more intrathecal therapy (IT) predicted fewer reactions (P = 2.4 × 10-5), which is consistent with an immunosuppressant contribution of IT. Anti-PEG-ASP was associated with accelerated drug clearance (P = 5.0 × 10-6). Failure of rechallenge after initial reactions was associated with anti-PEG-ASP (P = .0078) and was predicted by the occurrence of angioedema with first reaction (P = .01). CONCLUSION Less IT therapy was the only independent clinical risk factor for reactions to PEG-ASP. PEG, and not L-ASP, is the major antigen that causes allergic reactions. Anti-PEG-ASP has utility in predicting and confirming clinical reactions to PEG-ASP as well as in identifying patients who are most likely to experience failure with rechallenge.
Yield, Water Use Efficiency and Physiological Characteristic of “Tommy Atkins” Mango under Partial Rootzone Drying Irrigation System

This study was conducted to evaluate the yield, water use efficiency and physiologic characteristics of “Tommy Atkins” mango under partial rootzone drying. The experiment was carried out in an orchard of mango in the irrigated perimeter of Ceraima, BA. Five treatments and six repetitions were used with one tree per experimental plot: 01—Full Irrigation, 100% of ETc, 02—100% of ETc with frequency of alternance (FA) of 15 days, 03—80% ETc with FA of 15 days, 04—60% of ETc with FA of 15 days, 05—40% ETc with FA of 15 days. The treatments were conductedfrom the beginning of flowering to the harvest of mango in an orchard irrigated by drip. There was no significant reduction in productivity of “Tommy Atkins” mango under PRD up to 40% of ETc and PRD with 40% ETc resulted in greater water use efficiency. There was no significant difference among the averages of photosynthetically active radiation, Qleaf; leaf temperature, Tl; internal CO2 concentration, Ci; transpiration, E; stomatal conductance, gs; photosynthesis, A; carboxylation efficiency, A/Ci; quantum efficiency of photosynthesis, A/Qleaf and instantaneous water use efficiency, A/E between full irrigation and PRD with different water depth. The increase in leaf temperature causes reduction in A/Qleaf and A/E, however, it increases the transpiration. Increased gs results in higher rates of E, A and A/Ci. The use of the PRD with 40% of ETc causes no interference in gas exchange, maintains the yield and increases water use efficiency in “Tommy Atkins” mango tree.
Dynamics of sleep oscillations is coupled to brain temperature on multiple scales

Sleep spindle frequency positively, duration negatively correlates with brain temperature. Local heating of the thalamus produces similar effects in the heated area. Thalamic network model corroborates temperature dependence of sleep spindle frequency. Brain temperature shows spontaneous microfluctuations during both anesthesia and natural sleep. Larger fluctuations are associated with epochs of REM sleep. Smaller fluctuations correspond to the alteration of spindling and delta epochs of infra-slow oscillation.
Participatory On - Farm Evaluation and Demonstration of Improved Legume Forage Species in Benatsemay Woreda of South Omo Zone

Participatory field experiment was conducted at Kako and Chali peasant associations of Bena Tsemay woreda, South Omo Zone in the 2012 to 2013 main cropping seasons under rain fed conditions using the forage legume species to identify adaptable and high biomass yielding forage legume species. The field experiment was laid out in a randomized complete block design /RCBD/ with three replications where trial Agro pastoralists were considered as replications. The forage species used were Lablab intoritum, Lablab purepureus and Cow pea Legume. Each legume was planted in a single plot area of 3 m x 4 m = 12 m 2 . Dry matter production potential of the tested species in kako peasant association is 4.5, 5.6 and 5.20 t/ha and 3.4, 5.0, and 3.68 t/ ha for cropping year one and two respectively and where as the dry matter production potential of tested forage species trial location (Chali) is 5.2, 4.4 and 10 t/ha and 4, 3.2 and 5t/ha in year 2012 and 2013 respectively for Labalab purpureus, Lablab intoritum Cow pea. The result of for dry matter yield (DMY) revealed that there was no significant difference (P > 0.05 ) was observed among the tested forage legume species in the 2012 cropping season in Kako peasant association however, there was significant difference (P < 0.05) declared between Lablab purepureus and Lablab intoritum and Lablab intortum and Cow pea in the second cropping season. Out of the tested forge species over two years, the one which gave consistently the maximum dry matter yield was Lablab intoritum, which gave (10 tones ha -1 ), in the first cropping season and (5 tones ha -1 ) in the second cropping season is advisable for the study areas and their vicinities. Hence, use of the best performing forage species is important in the test community even though further testing is important by including their feeding value under different intervention and chemical composition to put the recommendation on strong basis. Keywords: Cow pea legume, forage dry matter yield, forage species, Lablab intortum, Lablab purepureus.
Effects of Regular Aerobic Exercise and Resistance Training on High-Density Lipoprotein Cholesterol Levels in Taiwanese Adults

Increased levels of high-density lipoprotein cholesterol (HDL-C) can improve endothelial function. This may help reduce cardiovascular risks and mortality. Evidence has been provided on the association between cardiometabolic traits, such as HDL-C and exercise modalities. However, there is the absence of studies investigating this association in Taiwan. We assessed the relationship between exercise type and HDL-C among Taiwanese adults. Data were collected from Taiwan Biobank (TWB), a national biomedical research database that contains the genetic information of ethnic Taiwanese residents gathered from 2008 to 2016. We enrolled 24,856 participants aged 30 to 70 years who completed a questionnaire about their recent health behaviors including smoking, drinking, and exercise. Regular exercise was categorized as non-aerobic exercise (separated as weight training, ball game, and mixed exercise) and strict aerobic exercise. Linear regression models were used to assess the effects of exercise in a questionnaire-based manner. After multivariate adjustments, HDL-C was positively associated with aerobic (β = 1.33748, p < 0.0001) and non-aerobic (β = 2.56210; p < 0.0001) exercise. Positive associations were also found for resistance training (β = 4.01828, p = 0.0020), ballgame (β = 2.43815, p = 0.0001), and mixed exercise (β = 2.47021, p < 0.0001). This study demonstrated that both aerobic and non-aerobic exercise have positive effects on HDL-C among Taiwanese adults. Among the non-aerobic exercise groups, resistance training had the greatest effect.
Integration of physical abuse clinical decision support at 2 general emergency departments

OBJECTIVE The study sought to develop and evaluate an electronic health record-based child abuse clinical decision support system in 2 general emergency departments. MATERIALS AND METHODS A combination of a child abuse screen, natural language processing, physician orders, and discharge diagnoses were used to identify children <2 years of age with injuries suspicious for physical abuse. Providers received an alert and were referred to a physical abuse order set whenever a child triggered the system. Physician compliance with clinical guidelines was compared before and during the intervention. RESULTS A total of 242 children triggered the system, 86 during the preintervention and 156 during the intervention. The number of children identified with suspicious injuries increased 4-fold during the intervention (P < .001). Compliance was 70% (7 of 10) in the preintervention period vs 50% (22 of 44) in the intervention, a change that was not statistically different (P = .55). Fifty-two percent of providers said that receiving the alert changed their clinical decision making. There was no relationship between compliance and provider or patient demographics. CONCLUSIONS A multifaceted child abuse clinical decision support system resulted in a marked increase in the number of young children identified as having injuries suspicious for physical abuse in 2 general emergency departments. Compliance with published guidelines did not change; we hypothesize that this is related to the increased number of children identified with suspicious, but less serious injuries. These injuries were likely missed preintervention. Tracking compliance with guidelines over time will be important to assess whether compliance increases as physician comfort with evaluation of suspected physical abuse in young children improves.
Relationships Between Gravity Waves Observed at Earth's Surface and in the Stratosphere Over the Central and Eastern United States

Observations of tropospheric gravity waves (GWs) made by the new and extensive USArray Transportable Array (TA) barometric network located east of the Rockies, in the central and eastern United States and of stratospheric (30–40 km above sea level) GWs made by the Atmospheric Infrared Sounder (AIRS) are compared over a 5 year time span from 2010 through 2014. GW detections in the period band from 2 to 6 h made at the Earth's surface during the thunderstorm season from May through August each year exhibit the same broad spatial and temporal patterns as observed at stratospheric altitudes. At both levels, the occurrence frequency of GWs is higher at night than during the day and is highest to the west of the Great Lakes. Statistically significant correlations between the variance of the pressure at the TA, which is a proxy for GWs at ground level, with 8.1 μm brightness temperature measurements from AIRS and rain radar precipitation data, which are both proxies for convective activity, indicate that GWs observed at the TA are related to convective sources. There is little, if any, time lag between the two. Correlations between GWs in the stratosphere and at ground level are weaker, possibly due to the AIRS observational filter effect, but are still statistically significant at nighttime. We conclude that convective activity to the west of the Great Lakes is the dominant source of GWs both at ground level and within the stratosphere.
Characteristics of herpes simplex virus infection and pathogenesis suggest a strategy for vaccine development

Herpes simplex virus (HSV) can cause oral or genital ulcerative lesions and even encephalitis in various age groups with high infection rates. More seriously, HSV may lead to a wide range of recurrent diseases throughout a lifetime. No vaccines against HSV are currently available. The accumulated clinical research data for HSV vaccines reveal that the effects of HSV interacting with the host, especially the host immune system, may be important for the development of HSV vaccines. HSV vaccine development remains a major challenge. Thus, we focus on the research data regarding the interactions of HSV and host immune cells, including dendritic cells (DCs), innate lymphoid cells (ILCs), macrophages, and natural killer (NK) cells, and the related signal transduction pathways involved in immune evasion and cytokine production. The aim is to explore possible strategies to develop new effective HSV vaccines.
Urbanization and Economic Growth in China¡ªAn Empirical Research Based on VAR Model

This paper takes the relation between urbanization and economic growth in China as the object of study. By using the time series data ranging from 1982 to 2014 and building VAR model, it analyzes, respectively, the dynamic relations between economic growth and the urbanization rate of resident population, the urbanization rate of land and the quality of urbanization. The paper comes up with the following conclusions: there exists a unidirectional causality between resident population urbanization and Chinai¯s economic growth, the former promoting the long-term growth of the latter; unidirectional causality also exists between land urbanization rate and Chinai¯s economic growth. However, different from resident population urbanization rate, it is the economic growth of China that promotes the increase of land urbanization rate and the increase of land urbanization rate cannot promote Chinai¯s economic growth; the relation between the quality of urbanization and Chinai¯s economic growth is a two-way causality. The improvement of urbanization quality has a cumulative positive effect on the economic growth of China, while economic growth has a negative effect on the improvement of urbanization quality in the short term and positive effect on economic growth in the long term.
Role of Leukotriene B4 Receptor-2 in Mast Cells in Allergic Airway Inflammation

Mast cells are effector cells in the immune system that play an important role in the allergic airway inflammation. Recently, it was reported that BLT2, a low-affinity leukotriene (LT) B4 receptor, plays a pivotal role in the pathogenesis of allergic airway inflammation through its action in mast cells. We observed that highly elevated expression levels of BLT2 are critical for the pathogenesis leading to allergic airway inflammation, and that if BLT2 expression is downregulated by siBLT2-mediated knockdown, allergic inflammation is dramatically alleviated. Furthermore, we demonstrated that BLT2 mediates the synthesis of vascular endothelial growth factor (VEGF) and Th2 cytokines, such as interleukin (IL)-13, in mast cells during allergic inflammation. Based on the critical roles of BLT2 in mast cells in allergic inflammation, anti-BLT2 strategies could contribute to the development of new therapies for allergic airway inflammation.
"Climate Change, Agricultural Productivity and Poverty"

This paper evaluates the impact of climate change on agricultural productivity and poverty. Cross-sectional variation in climate among Brazilian municipios is used to estimate a structural model where geographical attributes determine agricultural productivity and poverty. IPCC predictions based on 20 General Circulation Models (for 2030-2049) are used to simulate the impacts of climate change. Our estimates suggest that the global warming is expected to decrease the agricultural output per hectare in Brazil in 18 JEL Classi cation: R11; Q1; Q5; Q54; D12.
El Bienestar Subjetivo y la Utilización del Tiempo en Profesores Brasileños con Doctorado

The university professor suffers high pressure to achieve productivity and performs under work conditions that are not always satisfactory. This study seeks to analyze the subjective well-being, the time-use strategies, and the satisfaction with their use of time of PhD-holding professors with and without productivity grants from the National Council for Scientific and Technological Development (CNPq). A total of 83 professors participated in the study (48 with productivity grants), with an average age of 50 years. A total of 89% of participants were from public institutions. The majority of the participants exhibited high levels of negative affect and low-average levels of satisfaction with their use of time. There was no difference in the subjective well-being or in the satisfaction with the use of time when comparing professors who had received a CNPq grant with professors who had not received a CNPq grant. The most important reason for dissatisfaction with the use of time was an excess of work, whereas peer recognition was the primary achievement obtained with the work. How work demands and conditions influence the well-being of the professors is discussed in this study.
The Relationship between Social Capital within Its Different Contexts and Adherence to a Mediterranean Diet Among Lithuanian Adolescents

The eating habits of adolescents are a serious current public health problem. Scientists call attention to the availability of social resources for enhancing healthy eating behavior. Social capital defines those resources as trust, reciprocity, social participation, integrity, and coherence, and they are supposed to help people achieve their life goals, in general, and health goals, in particular. Our aim is to investigate the relationship between social capital within its different contexts and adherence to a Mediterranean diet (MD) among Lithuanian adolescents. The nationally representative cross-sectional study included 1863 students (906 boys and 957 girls). The KIDMED index questionnaire (Mediterranean Diet Quality Index in children and adolescents) was used to evaluate the adherence to an MD. Family, neighborhood, and school contexts of social capital were assessed using six items indicating family support, neighborhood trust, social control, vertical trust, horizontal trust, and reciprocity at school. Covariates such as gender, physical activity, parental education, and body mass index were also included in the analysis. Descriptive results showed that only 14% of Lithuanian adolescents followed an MD. Linear regression analysis indicated that family support (β = 0.096) and trust in school teachers (β = 0.074) were related to better rates of adherence, especially regarding the consumption of fruits, vegetables, cereals, fish, and the use of olive oil as a main source of fat. More adolescents who perceived family support and trust in their teachers used these products regularly and were less likely to skip breakfast. These findings could be used as a base for further developing nutrition education programs aimed at enhancing support and trust among families and schoolteachers.
Transitional Dynamics and Long-Run Optimal Taxation under Incomplete Markets ∗

Aiyagari (1995) showed that long-run optimal fiscal policy features a positive tax rate on capital income in Bewley-type economies with heterogeneous agents and incomplete markets. However, determining the magnitude of the optimal capital income tax rate was considered to be prohibitively difficult due to the need to compute the optimal tax rates along the transition path. Contrary to this view, this paper shows that in this class of models, long-run optimal fiscal policy and the corresponding allocation can be studied independently of the initial conditions and the transition path. Numerical methods based on this finding are used on a Ramsey model calibrated to the U.S. economy. I find that the observed average capital income tax rate in the U.S. is too high, the average labor income tax rate and the debt-to-GDP ratio are too low, compared to the long-run optimal levels. The implications of these findings for existing literature on the optimal quantity of debt and constrained efficiency are also adressed.