Miracle-dz/UniFAR-FTUs huggingface dataset:
Therapeutic angiogenesis in patients with systemic sclerosis by autologous transplantation of bone-marrow-derived cells

We examined the efficacy and safety of autologous transplantation of bone-marrow-derived cells in patients with intractable ulcers caused by systemic sclerosis. Eight patients with ulcers resistant to treatment were enrolled. Bone marrow cells were gathered from the bilateral iliac crests with multiple repositioning bone marrow needles, and bone-marrow-derived mononuclear cells were isolated and injected into skeletal muscles of the ischemic limb. Visual analog scale (VAS), Sclerosis Health Assessment Questionnaire (SHAQ), modified Rodnan total skin score (mTSS), and the size and depth of the ulcer were examined. Thermography, capillaroscopy, intra-arterial digital subtraction angiography (IA-DSA), and laser Doppler flowmetry were also examined before and after transplantation. In all patients, reduction of ulcer size and improvement of VAS were observed after treatment. Elevation of surface temperature, increase of blood flow volume, and new capillaries of the nail bed were also found after our treatment. There were no major adverse effects of this treatment. Autologous transplantation of bone-marrow-derived cells was shown to be a novel and useful approach to intractable ulcers in systemic sclerosis.
Hazards Assessment of Radon Exhalation Rate and Radium Content in the Soil Samples in Iraqi Kurdistan Using Passive and Active Detecting Methods

— This study aims to assess the environmental hazards from radon exhalation rate in the soil samples in selected locations in Iraqi Kurdistan, using passive (CR-39NTDs) and active (RAD7) detecting method. Radon concentration, effective radium content and radon exhalation rate were estimated in soil samples that collected at the depth level of 30 cm inside 124 houses. The results show that the emanation rate for radon gas was variation from location to other, depending on the geological formation. Most health risks come from emanation of radon and its daughter due to its contribution for indoor radon, so the results showed that there is a linear relationship between the ratio of soil and indoor radon concentration (C Soil Rn222 / C indoor Rn222 ) and the effective radium content in soil samples. The results show that radon concentration has high and low values in Hajyawa city and Er. Tyrawa Qr, respectively. A comparison between our results with that mentioned in international reports was done.
The Relationship between Serum Cholesterol and Serum Thyroid Hormones in Male Patients with Suspected Hypothyroidism

The relationship between serum cholesterol, thyrotropin, thyroxine and triiodothyronine was investigated in 456 male patients with suspected hypothyroidism. The correlation between serum cholesterol and serum thyroxine (r = 0·0572) and between serum cholesterol and serum triiodothyronine (r = 0·1136) were not significant but the correlation between serum cholesterol and TSH (r = 0·0376) was significant (P< 0·001). The mean serum cholesterol was only significantly increased in the patient groups with a serum TSH greater than 20 mU/L. In 26 patients treated for hypothyroidism with thyroxine replacement there was a significant correlation between the decrease in serum cholesterol and the decrease in serum TSH (r = 0·5334, P<0·01) but there was poor correlation between the decrease in cholesterol and either the increase in serum triiodothyronine or the increase in serum thyroxine.
The essential function of Not1 lies within the Ccr4-Not complex.

The five Saccharomyces cerevisiae Not proteins are associated with the Ccr4 and Caf1 proteins in 1.2 MDa and 2 MDa complexes. The Not proteins have been proposed to repress transcription of promoters that do not contain a canonical TATA sequence, while the Ccr4 and Caf1 proteins are required for non-fermentative gene expression. The mechanism of transcriptional regulation by the Ccr4-Not complex is unknown and the role of its different components is unclear. Only Not1p is essential for yeast viability.Here, we show that most strains carrying combinations of two null alleles of the non-essential CCR4-NOT genes are non-viable. This would suggest that the Ccr4-Not complex is essential. We find that Not1p consists of at least two domains, a C-terminal domain that is essential for yeast viability, and a N-terminal domain that is dispensable but required for yeast wild-type growth. The essential C-terminal domain of Not1p can associate with Not5p, and both proteins are present in 1.2 and 2 MDa complexes in the absence of the N-terminal Not1p domain. In contrast, in the absence of the N-terminal domain of Not1p, Ccr4p does not efficiently associate in large complexes nor with the C-terminal domain of Not1p. Healthy growth is observed when both domains of Not1p are expressed in trans, and is correlated with their physical association, together with Ccr4p, in large complexes. These results are consistent with the essential function of Not1p lying within the Ccr4-Not complex.
Looking Forward

Over the past quarter century, researchers have developed a body of parent training programs that have proven effective in reducing child behavior problems, but few of these have made their way into routine practice. This article describes the long and winding road of implementation as applied to children’s mental health. Adopting Rogers’ (1995) diffusion framework and Fixsen and colleagues’ implementation framework (Fixsen, Naoom, Blase, Friedman, & Wallace, 2005), we review more than a decade of research on the implementation of Parent Management Training—Oregon Model (PMTO). Data from U.S. and international PMTO implementations are used to illustrate the payoffs and the challenges of making empirically supported interventions routine practice in the community. Technological advances that break down barriers to communication across distances, the availability of efficacious programs suitable for implementation, and the urgent need for high quality mental health care provide strong rationales for prioritizing implementation. Over the next quarter of a century, the challenge is to reduce the prevalence of children’s psychopathology by creating science-based delivery systems to reach families in need, everywhere.
The mRNA export machinery requires the novel Sac3p–Thp1p complex to dock at the nucleoplasmic entrance of the nuclear pores

Yra1p and Sub2p are components of the TREX complex, which couples transcription elongation with nuclear export of mRNAs. Here, we report a genetic interaction between Yra1p and a conserved protein Sac3p, which previously was found to interact with Sub2p. In vivo, Sac3p forms a stable complex with Thp1p, which was reported to function in transcription elongation. In addition, Sac3p binds to the mRNA exporter Mex67p–Mtr2p and requires the nucleoporin Nup1p to dock at the nuclear side of the nuclear pore complex (NPC). Significantly, mutations in Sac3p or Thp1p lead to strong mRNA export defects. Taken together, our data suggest that the novel Sac3p–Thp1p complex functions by docking the mRNP to specific nucleoporins at the nuclear entrance of the NPC.
Nouns in early lexicons: evidence, explanations and implications

ABSTRACT Many theories of grammatical and lexical acquisition assume that children learn predominantly nouns, and specifically names of objects, when they first begin to acquire words in the second year. We show that the noun bias in early vocabularies is far from universal, and that it rests only in part on the acquisition of object names. An analysis of vocabulary composition from 45 children at 1;8 indicates that more nouns are acquired than all other word classes, but that of the nouns acquired only about half are the names of basic level object classes (BLOCS). An examination of the use of nouns in mother-child discourse shows that non-object words referencing locations, actions and events, for example, are used in distinctive pragmatic and grammatical contexts which might enable a child to grasp the word's use and eventually its meaning. It is concluded that a theory of lexical acquisition in discourse context is required to explain word learning at all levels and for all word types. Implications for semantic bootstrapping theories are considered.
Relationship between Class I and II HLA Antigens in Schizophrenia and Eye Movement Disturbances: A Preliminary Study

The region coding human leukocyte antigen (HLA) on chromosome 6q21 was shown to be associated with both the vulnerability to schizophrenia and presence of eye movement disturbances (EMD). The aim of this preliminary study was to investigate how individual class I and II HLA antigens in schizophrenic patients may be related to schizophrenia and to the intensity of two kinds of EMD: fixation and smooth pursuit. The incidence of HLA antigens was compared between 40 schizophrenic patients (17 male, 23 female) and 198 healthy control subjects (112 male, 86 female). In schizophrenic patients, the intensity of EMD assessed by infrared reflectometry and quantified on a scale from 0 to 3 was correlated with the incidence of HLA antigens. A number of differences regarding HLA antigens were found between schizophrenic patients and healthy subjects. Significant correlation was also obtained between some EMD and a number of HLA antigens. Antigens A24 and A28 were found to occur in different frequencies in schizophrenic patients and healthy control subjects. They also correlated with EMD on the fixation and smooth pursuit tests. The results obtained show an association between HLA antigens and EMD as an endophenotypic marker of schizophrenia, and may add to other findings on susceptibility loci for schizophrenia on chromosome 6p21. A limitation of this study is a small number of investigated patients with schizophrenia.
Transfusion of Platelet Concentrates Prepared from Acidified Platelet‐Rich Plasma *

With the use of Aster's and excess ACD solutions, the recovery of chromium51‐labeled platelets was greater, and the sequestration phenomenon decreased in patients without hematologic disease, compared with preparations collected in the normal amounts of ACD as the anticoagulant. Analysis of platelet counts following transfusions of platelet concentrates demonstrated a significant increase of platelets in transfused leukemic patients using acidified preparations as compared with those collected in normal amounts of ACD. The use of additional ACD solution which is routinely available in the blood bank appears to be a satisfactory method to prepare the acidified platelet concentrates.
Treated wastewater irrigation effects on soil hydraulic conductivity and aggregate stability of loamy soils in Israel

Abstract The use of treated wastewater (TWW) for agricultural irrigation becomes increasingly important in water stressed regions like the Middle East for substituting fresh water (FW) resources. Due to elevated salt concentrations and organic compounds in TWW this practice has potential adverse effects on soil quality, such as the reduction of hydraulic conductivity (HC) and soil aggregate stability (SAS). To assess the impact of TWW irrigation in comparison to FW irrigation on HC, in-situ infiltration measurements using mini disk infiltrometer were deployed in four different long-term experimental orchard test sites in Israel. Topsoil samples (0-10 cm) were collected for analyzing SAS and determination of selected soil chemical and physical characteristics. The mean HC values decreased at all TWW sites by 42.9% up to 50.8% compared to FW sites. The SAS was 11.3% to 32.4% lower at all TWW sites. Soil electrical conductivity (EC) and exchangeable sodium percentage (ESP) were generally higher at TWW sites. These results indicate the use of TWW for irrigation is a viable, but potentially deleterious option, as it influences soil physical and chemical properties.
Preparation and Characteristics of Biomass Char

Rice husk and sawdust were selected as the raw materials for a study of biomass char yield in the range of 600 to 900 °C. It was found that temperature was the primary factor affecting the biomass char yield. The yield of the rice husk and sawdust chars decreased significantly with increasing temperature. As the residence time increased, the biomass char yield decreased. The smaller the size of the biomass particles, the higher the char yield. When the temperature exceeded 800 °C, the difference in the char yield was only slight. Given this finding, the surface morphologies of rice husk, sawdust, and their respective chars were investigated under various conditions via scanning electron microscopy. The effects of temperature on the pore structures were investigated by the Accelerated Surface Area and Porosimetry System. There were more holes in the biomass char, and the specific surface area was increased significantly as the temperature increased. The specific surface areas of rice husk and sawdust chars prepared at 900 °C were 320 and 1140 m2/g, respectively.
Diagnostic Errors in a PICU: Insights From the Morbidity and Mortality Conference*

Objectives: To describe diagnostic errors identified among patients discussed at a PICU morbidity and mortality conference in terms of Goldman classification, medical category, severity, preventability, contributing factors, and occurrence in the diagnostic process. Design: Retrospective record review of morbidity and mortality conference agendas, patient charts, and autopsy reports. Setting: Single tertiary referral PICU in Baltimore, MD. Patients: Ninety-six patients discussed at the PICU morbidity and mortality conference from November 2011 to December 2012. Interventions: None. Measurements and Main Results: Eighty-nine of 96 patients (93%) discussed at the PICU morbidity and mortality conference had at least one identified safety event. A total of 377 safety events were identified. Twenty patients (21%) had identified misdiagnoses, comprising 5.3% of all safety events. Out of 20 total diagnostic errors identified, 35% were discovered at autopsy while 55% were reported primarily through the morbidity and mortality conference. Almost all diagnostic errors (95%) could have had an impact on patient survival or safety. Forty percent of errors did not cause actual patient harm, but 25% were severe enough to have potentially contributed to death (40% no harm vs 35% some harm vs 25% possibly contributed to death). Half of the diagnostic errors (50%) were rated as preventable. There were slightly more system-related factors (40%) solely contributing to diagnostic errors compared with cognitive factors (20%); however, 35% had both system and cognitive factors playing a role. Most errors involved vascular (35%) followed by neurologic (30%) events. Conclusions: Diagnostic errors in the PICU are not uncommon and potentially cause patient harm. Most appear to be preventable by targeting both cognitive- and system-related contributing factors. Prospective studies are needed to further determine how and why diagnostic errors occur in the PICU and what interventions would likely be effective for prevention.
No Significant Difference Phenomenon

The No Significant Difference Phenomenon (NSDP) is designed and arranged differently from other monographs or books. NSDP contains a compilation of briefly described research findings related to the effective use of technology, chiefly distance learning, compared to alternative methods or techniques of teaching. The annotated studies are arranged chronologically by year beginning in 1928 and ending in 1998. There are 355 research reports, summaries, and papers cited in which no significance difference was reported between the variables compared.
The Effect of Temperature, pH, and Food additives on Tomato Product Volatile Levels

Temperature, NaCl, pH, pectin, protein, sucrose, and oil were varied in tomato juice, as a model for flavored tomato sauces, to determine the effect on volatile levels. The headspace concentrations of different tomato juice samples were measured by selected ion flow tubemass spectrometry (SIFT-MS). Temperature produced the greatest increase, followed by the addition of NaCl. pH and pectin produced no significant difference, while protein, sucrose, and oil decreased volatile levels. Sensory testing showed that NaCl, control, and sucrose had the highest aroma intensity and consumer preference followed by pectin and milk protein and finally oil. In general, the higher the volatile concentration, the stronger the preference, without an indication that any change in volatile ratios produced a detectible off-odor.
Effectiveness of a Cloud-Based EHR Clinical Decision Support Program for Body Mass Index (BMI) Screening and Follow-up

The effectiveness of a clinical decision support (CDS) program encouraging clinicians to record patient's Body Mass Index (BMI) and document appropriate follow-up plans is evaluated. Test (4,987 practices, 33,445 clinicians) and control groups (881 practices, 6,316 clinicians) were selected using stratified random sampling. Three CDS alerts for BMI screening and follow-up based on evidence based clinical quality guidelines were displayed at the point of care in a cloud-based EHR. The effectiveness of the CDS program was measured over 4 months by tracking recorded BMI and documented follow-up plans. Over the program, BMI recording increased minimally and documentation of follow-up plans increased 5-fold (p=0.05) compared to the control group. The overweight test group patients (18- 64yo) gained less weight (p=0.06) than the control group and underweight patients gained more weight (p<0.01) during the program period. Outcome studies with longer follow-up periods are needed to further confirm positive outcomes.
Role of estrogen deficiency in the formation and progression of cerebral aneurysms. Part II: experimental study of the effects of hormone replacement therapy in rats.

OBJECT The increased incidence of cerebral aneurysms in postmenopausal women appears to be related to low levels of circulating estrogen. Using a rat model of aneurysm induction, the authors found that oophorectomy increased the incidence of experimental cerebral aneurysms (Part I in this issue). In the current study they examined the effects of hormone replacement therapy (HRT) on the formation of cerebral aneurysms in rats. METHODS Forty-five female Sprague-Dawley rats were divided into three equal groups. The animals in Groups A and B were subjected to a cerebral aneurysm induction procedure (renal hypertension and right common carotid artery ligation) followed 1 month later by bilateral oophorectomy. After an additional week the rats in Group A received 17beta estradiol continuous-release pellets. The rats in Group C served as controls. Three months after the aneurysm induction procedure, all the rats were killed and vascular corrosion casts of their cerebral arteries were prepared and checked for aneurysmal changes. Using a scanning electron microscope, the authors recorded aneurysmal changes as endothelial changes alone (Stage I), endothelial changes with intimal pad elevation (Stage II), and saccular aneurysm formation (Stage III). Aneurysmal changes (Stages I, II, and III) occurred in one third of rats that had undergone oophorectomy and were receiving HRT (Group A), compared with 87% of the rats that had undergone oophorectomy but did not receive HRT (Group B). Although most of the aneurysmal changes identified in Group A rats were limited to Stage I or II, most changes in Group B animals were identified as saccular dilation (Stage III). CONCLUSIONS The findings demonstrated the significant protective role of estrogen against the formation and progression of cerebral aneurysms. It appears to be related to the beneficial effects of estrogen on the function and growth of endothelial cells, which play a major role in preserving the integrity of the vascular wall.
Optimal ventilator settings in acute lung injury and acute respiratory distress syndrome

Despite recent advances in intensive care medicine, acute lung injury and its more severe form, acute respiratory distress syndrome pose major therapeutic problems. While mechanical ventilation is integral to the care of these patients, its adverse consequences including ventilator‐induced lung injury are determinants of disease progression and prognosis. Among several important ventilator parameters, the use of low tidal volumes is probably the most important feature of lung‐protective mechanical ventilation. Intensivists should be trained to recognize acute lung injury and acute respiratory distress syndrome and encouraged to use low‐tidal‐volume ventilation in clinical practice. Alternative modes of ventilation such as high‐frequency ventilation and prone position should be reserved for selected patients in whom conventional lung‐protective ventilation strategies have failed.
Reconstruction of the posterior cruciate ligament. Indications and results.

©2004 British Editorial Society of Bone and Joint Surgery doi:10.1302/0301-620X.86B4. 15010 $2.00 J Bone Joint Surg [Br] 2004;86-B:480-91. Renewed interest in injuries to the posterior cruciate ligament (PCL) and its associated structures has resulted in an increasing number of reports on the anatomy, biomechanics, diagnosis and treatment. However, set against our knowledge of the management of injuries to the anterior cruciate ligament, that of injuries to the PCL is less clear. There are many reasons for this. Injuries to the PCL are much less common; an individual surgeon will see very few each year and his experience will be limited. Acute cases are often missed, either from lack of experience of the original examiner or because the patient does not realise the severity of the injury and does not seek medical help at the acute stage. Attempts at treatment in the past have produced relatively poor results and the indications for surgery are unclear. With increasing knowledge the situation is improving. Methods of diagnosis from clinical examination and special investigations are becoming more widely known and these, together with a high index of suspicion, should lead to the identification of a greater number of these injuries. Until recently, the natural history of isolated PCL injuries was unclear. The literature contained many retrospective studies with small numbers of cases and a varied aetiology. Their conclusions led to confusion. More recent prospective papers have aided clarification. The importance of the posterolateral corner in relation to PCL injuries has been increasingly understood both from original biomechanical studies and clinical observation. Without attention to injuries to this site the treatment of rupture of the PCL may be compromised and failure almost inevitable. Injuries to the PCL may be associated with multiple damage to other ligaments of the knee including dislocation. The management of complex injuries is beyond the scope of this review, but the basic principles will be described including the importance of injury to the PCL. Early surgical treatment has been advocated by most experienced surgeons, but few comparative studies of conservative versus operative treatment are available. While there have been many reports of methods of reconstruction of the PCL and associated structures, few long term results are available. Future knowledge and understanding will depend on prospective studies on specific forms of treatment allowing the surgeon to make an objective assessment and be armed with accurate information to provide the best treatment.