Miracle-dz/UniFAR-FTUs huggingface dataset:
Ruxolitinib as an emerging treatment in myelofibrosis

Correspondence: Ruben A Mesa Division of Hematology and Oncology, Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, AZ, USA Tel +1 480 301 4502 Fax +1 480 301 4675 Email mesa.ruben@mayo.edu Abstract: Essential thrombocythemia, polycythemia vera, and myelofibrosis belong to the class of Bcr-Abl negative hematologic neoplasms, which arise in part from varying Janus kinase-2 (JAK2) cellular deregulation. With the development of novel tyrosine kinase inhibitors capable of successfully inhibiting JAK in vivo, an influx of JAK2 inhibitors has come under clinical investigation. Ruxolitinib (Jakafi; Incyte Corporation, Wilmington, DE, USA) was the first of these compounds to gain US Food and Drug Administration approval in late 2011 for the treatment of intermediateand high-risk myelofibrosis. Two Phase III clinical trials – Controlled Myelofibrosis Study with Oral JAK Inhibitor Treatment-I and -II (COMFORT-I and -II) – played key roles in the US Food and Drug Administration approval of ruxolitinib with successful demonstration of spleen reduction and symptom palliation. Well tolerated in most patients, common side effects include cytopenias and gastrointestinal toxicities. The majority of preliminary data appears to suggest that if administered in a dose-titrated fashion, ruxolitinib can be used safely in a clinical practice setting. Additionally, patients most likely to benefit from ruxolitinib treatment are those with moderate to severe constitutional symptoms or splenomegaly. Future studies are ongoing in applying ruxolitinib to other hematologic and solid tumor malignancies. More clinical experience is recommended before the utility of this medication in a routine clinical practice setting can be fully determined.
Financial Accounting Regulation and Executive Compensation Design

We examine the economic consequences of the recent adoption of SFAS 123(R) in the United States. Consistent with the conjectures of prior research, our results show that the removal of favorable accounting treatment for stock options post SFAS 123(R) results in a switch from stock options to restricted stock. Further analysis shows that this shift is more prominent for high-volatility firms than for low-volatility firms and for low-growth firms than for high-growth firms, a pattern consistent with the implications of the agency theory. This study extends the literature on the economic consequences of financial reporting standards by providing evidence that the leveling of accounting treatment for different forms of equity compensation causes the design of executive compensation to converge to the economically optimal form. By empirically examining the actual consequences of a heavily debated accounting standard change, this study also provides important policy implications that can be helpful in the consideration of future regulatory accounting changes in the United States as well in other accounting jurisdictions.
Value Relevance of Book Value & Earnings Under the Local GAAP and IFRS: Evidence from Turkey

This study examines empirically the impact of International Financial Reporting Standards (IFRS) on the value relevance of accounting information in Turkey. Turkish listed firms on the Istanbul Stock Exchange (ISE) are required to adopt IFRS in the preparation and presentation of their financial statements since 2005. Using the equity valuation model as suggested by Ohlson (1995), firstly, the value relevance of earnings and book values of equity produced under Turkish Local Standards (during 2000-2002) and under IFRS (during 2005-2009) is analyzed. And then, these two periods are compared to investigate whether the mandatory adoption of IFRS has an impact on value relevance of accounting information. The analysis results show that earnings and book value are, jointly and individually, positively and significantly related to stock price under the two different reporting regimes. Additionally, the results provide that book value of equity is more value relevant than earnings. When two different reporting standards are compared, it is found that the adoption of IFRS increased the value relevance of accounting information for Turkish listed firms. This study contributes to the existing literature on the value relevance of accounting information and to the debate over the mandatory adoption of IFRS.
Palmitoleic Acid Infusion Alters Circulating Glucose and Insulin Levels

Objectives: The objectives of these studies are to evaluate: 1) uptake of a pulse dose of 13 C16:1 cis-9 at varying levels into the blood and 2) glucose and insulin changes after pulse dose of 0 or 5 mg C16:1 cis-9/kg body weight (BW) under challenge conditions in obese lambs. Methods: Two experiments were conducted to evaluate uptake of U- 13 C16:1 cis-9 into the blood and changes in glucose and insulin under challenges. In the first experiment, lambs (67.4 ± 1.4 kg BW, n=3) received jugular catheters and were used in a 3 x 3 Latin square. Treatments were 0, 2 or 5 mg/kg BW of U- 13 C16:1 cis-9 in 40% (wt/v) ethanol and blood samples were collected post infusion for glucose, fatty acid and insulin analyses. In the second experiment, lambs (86.7 ± 1.5 kg BW; n=4) received jugular catheters. Treatments were 0 or 5 mg/kg BW of C16:1 in 40% (wt/v) ethanol immediately followed by a glucose (0.25 g/kg) or insulin (0.02 mIU/kg) challenge. Results: Both the 2 and 5 mg/kg BW dose of U- 13 C16:1 cis-9increased (P=0.003) C16:1 cis-9in serum compared to 0 mg/kg BW. The 5 mg/kg BW dose had a greater magnitude of increase for serum C16:1 and resulted in increased whole blood glucose levels for first 60 min and altered insulin levels for first 30 min. During the glucose tolerance test, C16:1bolus infusion increased (P=0.02) peak, overall, and area under the curve for plasma glucose levels. During the insulin challenge, C16:1-treated lambs had increased glucose levels (P=0.04) and peak, overall, and area under the curve plasma insulin (P=0.0001).
BAFF Expression is Increased in Patients with Lupus Nephritis and Associated with Antinucleosome Antibodies , C 1 Inhibitor , Α1-Acid-Glycoprotein and Endothelial Activation Markers

Objectives: B cell activating factor (BAFF) inhibitor therapy has recently been approved for non-renal Systemic Lupus Erythematosus (SLE). While BAFF plays a role in experimental lupus nephritis (LN), its role human LN is not well studied. Methods: Case control study in 102 SLE patients, 30 with LN (+LN) and 72 without LN (-LN) and 31 healthy controls. We analysed BAFF mRNA expression in PBMCs (BAFF-RQ) and serum BAFF (s-BAFF) levels and investigated their relation with clinical, histologicaland additional acute phase proteins. Results: s-BAFF and BAFF-RQ were increased in +LN patients compared to controls, but their expression did not correlate with ISN/RPS class, Activityor Chronicity index on biopsy. s-BAFF correlated with levels of anti-nucleosome antibodies, C1 inhibitor and α-1-acid-glycoprotein (AGP), while BAFF-RQ correlated inversely with Factor VIII. Conclusions: s-BAFF and BAFF mRNA levels are increased in LN patients, but do not reflect histological disease severity. The association of increased BAFF expression with both proand anti-inflammatory markers and reduced endothelial activation suggest that BAFF inhibition in LN may have diverse effects. Citation: Eilertsen GØ, Ghelue MV, Nossent JC (2012) BAFF Expression is Increased in Patients with Lupus Nephritis and Associated with Antinucleosome Antibodies, C1 Inhibitor, Α-1-Acid-Glycoprotein and Endothelial Activation Markers. J Data Mining in Genom Proteomics 3:113. doi:10.4172/2153-0602.1000113
ASSESSMENT OF THE ECOLOGICAL STATE OF SMALL WATER RESERVOIRS IN THE LUBLIN REGION

Summary. The aim of the study was to determine the diversity of ecological state of small reservoirs of hydrogenic landscapes in the Lublin region, varying in size, origin, land usage of adjacent areas, as well as the way of their usage. The research was carried out in 11 water reservoirs situated in different parts of Lublin Region. Examined small water reservoirs were varied in terms of ecological status. The largest group were the reservoirs of moderate natural values – class III. To this group belonged mainly reservoirs with the lowest surrounding valorisation. Huge impact on the natural values of small water reservoirs had use of reservoir and its catchment. Reservoirs of natural origin, not subjected to anthropogenic pressure characterized by the highest values.
Physico-chemical and Biological Variables of Hospitals Wastewater in Erbil City

Three hospitals were chosen(Maternity hospital, Raperin hospital and Rhizgari hospital) for the present survey within Erbil city. Water samples were collected at regular monthly interval periods beginning in January 2012 to December 2012. pH of all the studied sites were found to be up 7. Electrical conductivity ranged from (1318-1790 µs. cm -1
Stock Price Synchronicity and Liquidity

We argue and provide evidence that stock price synchronicity affects stock liquidity. Under the relative synchronicity hypothesis, higher return co-movement (i.e., higher systematic volatility relative to total volatility) improves liquidity. Under the absolute synchronicity hypothesis, stocks with higher systematic volatility or beta are more liquid. Our results support both hypotheses. We find all three illiquidity measures (effective proportional bid-ask spread, price impact measure, and Amihud's illiquidity measure) are negatively related to stock return co-movement and systematic volatility. Our analysis also shows that larger industry-wide component in returns improves liquidity. We find that improvement in liquidity following additions to the S&P 500 Index is related to the stock's increase in return co-movement.
Burial-nutrient feedbacks amplify the sensitivity of atmospheric carbon dioxide to changes in organic matter remineralisation

Abstract. Changes in the marine remineralisation of particulate organic matter (POM) and calcium carbonate potentially provide a positive feedback with atmospheric CO2 and climate change. The responses to changes in remineralisation length scales are systematically mapped with the Bern3D ocean–sediment model for atmospheric CO2 and tracer fields for which observations and palaeoproxies exist. Results show that the "sediment burial-nutrient feedback" amplifies the response in atmospheric CO2 by a factor of four to seven. A transient imbalance between the weathering flux and the burial of organic matter and calcium carbonate lead to sustained changes in the ocean's phosphate and alkalinity inventory and in turn in surface nutrient availability, marine productivity, and atmospheric CO2. It takes decades to centuries to reorganise tracers and fluxes within the ocean, many millennia to approach equilibrium for burial fluxes, while δ13C signatures are still changing 200 000 years after the perturbation. At 1.7 ppm m−1, atmospheric CO2 sensitivity is about fifty times larger for a unit change in the remineralisation depth of POM than of calcium carbonate. The results highlight the role of organic matter burial in atmospheric CO2 and the substantial impacts of seemingly small changes in POM remineralisation.
Environmental constraints on Holocene cold‐water coral reef growth off Norway: Insights from a multiproxy approach

High-latitude cold-water coral (CWC) reefs are particularly susceptible due to enhanced CO2 uptake in these regions. Using precisely dated (U/Th) CWCs (Lophelia pertusa) retrieved during research cruise POS 391 (Lopphavet 70.6°N, Oslofjord 59°N) we applied boron isotopes (δ11B), Ba/Ca, Li/Mg and U/Ca ratios to reconstruct the environmental boundary conditions of CWC reef growth. The sedimentary record from these CWC reefs reveals a lack of corals between ∼ 6.4 and 4.8 ka. The question remains if this phenomenon is related to changes in the carbonate system or other causes. The initial postglacial setting had elevated Ba/Ca ratios, indicative of meltwater fluxes showing a decreasing trend towards cessation at 6.4 ka with a oscillation pattern similar to continental glacier fluctuations. Downcore U/Ca ratios reveal an increasing trend, which is outside the range of modern U/Ca variability in L. pertusa, suggesting changes of seawater pH near 6.4 ka. The reconstructed BWT at Lopphavet reveals a striking similarity to Barent Sea-Surface and sub-Sea-Surface-Temperature records. We infer that meltwater pulses weakened the North Atlantic Current system resulting in southward advances of cold and CO2 rich Arctic waters. A corresponding shift in the δ11B record from ∼ 25.0‰ to ∼ 27.0 ‰ probably implies enhanced pH-up regulation of the CWCs due to the higher pCO2 concentrations of ambient seawater, which hastened Mid-Holocene CWC reef decline on the Norwegian Margin.
Closing the Loop on E‐waste: A Multidisciplinary Perspective

This paper describes the challenges faced, and opportunities identified, by a multidisciplinary team of researchers developing a novel closed loop system to recover valuable metals and reduce e‐waste, focusing on mobile phones as a case study. This multidisciplinary approach is contrasted with current top‐down approaches to making the transition to the circular economy (CE). The aim of the research presented here is to develop a product service system (PSS) that facilitates the recovery of valuable functional components and metals from mobile phone circuit boards. To create a holistic solution and limit unintended consequences, in addition to technological solutions, this paper considers appropriate component lifetimes; the (often ignored) role of the citizen in the circular economy; customer interaction with the PSS; environmental life cycle assessment; and social impacts of the proposed PSS. Development of enabling technologies and materials to facilitate recovery of components and metals and to provide an emotionally durable external enclosure is described. This research also highlights the importance of understanding value in the CE from a multifaceted and interdisciplinary perspective.
Black Hole Masses and Eddington Ratios of AGNs at z < 1: Evidence of Retriggering for a Representative Sample of X-Ray-selected AGNs

We estimated black hole masses and Eddington ratios for a sample of X-ray-selected active galactic nuclei (AGNs) in the fields covered by the Great Observatory Origins Deep Survey (GOODS). The spanned ranges in redshift (0.4 < z < 1) and hard X-ray luminosity (1042 ≲ LX ≲ 4 × 1043 ergs s-1) allow us to study a representative subsample of the main contributors to the 2-10 keV X-ray background. Nuclear and bulge magnitudes in four bands have been measured via a two-dimensional decomposition applied to HST ACS images. Using the black hole versus bulge luminosity relation and the intrinsic nuclear emission, we derived the black hole mass and the AGN bolometric luminosity. We find in our sample that (1) the X-ray-to-optical indices are larger than in optically selected QSOs, as expected due to the X-ray selection); (2) the X-ray bolometric corrections are generally small, suggesting a decrease with the nuclear luminosity; (3) the Eddington ratios are about a factor 10 below the values found at higher redshift and luminosity; (4) the central black holes have rather large masses; and (5) at least for z ≲ 0.8, a scarceness of black holes with mass MBH ≤ 106 M☉ and accretion rate near the Eddington limit: this result could be ascribed to a decline in their number density, or it could suggest a substantial accretion at higher redshift (z ≳ 1) also for these smaller black holes.
Comparison of copper and glass oscillating heat pipes with Fe2O3 under magnetic field.

This paper presents the findings from an experimental investigation on the performance effect of magnetic field when applied to oscillating heat pipes (OHPs) using kerosene with Fe2O3 nanoparticles as the working fluid. Two types of OHPs were used in this investigation: copper surface OHP and glass surface OHP. The temperature distribution and heat transfer rate through the OHPs were monitored and recorded with and without the magnetic field. In addition, the effect of surface condition on heat transfer for the copper and glass OHPs was investigated. The results have shown that the heat transfer performance of the OHPs improved with the addition of nanoparticles. This improvement was greatly enhanced by the application of magnetic field especially at the higher heat load regions and was more superior for the copper OHP with Fe2O3 nanofluid.
Exploring Foreign Direct Investments in Developing African Countries: Their Effects on the Economic Growth in Cameroon (2006-2011)

This study explores Foreign Direct Investment (FDI) and its effects on the economic growth in Cameroon within the period 2006-2011. The purpose of this study is to understand the reason why increased FDI had not led to more economic growth in Cameroon. Aghion’s endogeneity growth theory was used as a guide to data collection and analysis. Research data were collected from 20 investment managers with close relationships with Cameroon. The participants included five from each subgroup of energy, health care, technology, and financial institutions, in the United States. The study participants expressed strong commitment towards economic growth in Cameroon. The responses from the study participants showed inconsistency with the literature review and the belief that FDI generates economic growth in the developing countries. Moreover, the respondents reported bureaucracy and corruption as the possible challenges facing the economic growth in Cameroon. The research participants believed that eco-political factors directly affect the economic growth in Cameroon. Policy implications and recommendations for future studies were stated. It was recommended that the country must improve its financial market by removing financial restraints that hinder Cameroon firms from getting into export markets. In addition, the Cameroon leaders should focus on improving human capital through training and development. Training methods must be improved; a comprehensive plan for training and development must be implemented. Moreover, Cameroon leaders should ensure that their attention to FDI does not overshadow domestic small businesses. The study established that although there were positive relationships between FDI and economic growth in the developing countries such as Cameroon, the findings were inconclusive. Future research should further study the effects of FDI on economic growth using endogeneity growth theory in multi developing countries to determine if the study findings from this dissertation can be supported in other settings.
TRENDS IN CONSUMER ACCEPTANCE AND AWARENESS OF BIOTECHNOLOGY

The promise of agricultural biotechnology has become reality. Foods produced through biotechnology will become increasingly common in the food production and distribution system. Consumer reaction to these foods will be an important factor in determining the ultimate success of the biotechnology enterprise. This paper reviews trends in U.S. consumers' awareness and acceptance of biotechnology. Results of several national surveys show that biotechnology has not been an issue for the vast majority of consumers. Most have a positive attitude about biotechnology. This paper also presents some implications for future research and educational programs.
Channel flow over curved boundaries and a new hydraulic theory

Dressler (1978) derived the St Venant long wave equations for two-dimensional irrotational flow over curved boundaries using orthogonal curvilinear coordinates based on the channel bottom. These equations are considerably more complicated than those in the cartesian system, but they do contain contributions to the pressure and the governing equations from the curvature of the bed, which does not occur in the cartesian formulation at the same level of approximation. Similarly, Chapman and Dressler (1984) obtained the shallow water equations for unsteady shallow groundwater flow with a free surface over a curved impermeable boundary. In both these cases, the flow was assumed to be irrotational, which is well-known to be justified in the case of seepage flow and for wave motion on otherwise quiescent fluid, but not so justified in the case of fast hydraulic flows such as over spillways.
Curbing Creative Accounting: Do Religious Environment and Individual Attribute Matter?

Akuntansi kreatif merupakan dilema etis karena seakan-akan tidak melanggar aturan tetapi menyebabkan pengguna laporan keuangan salah dalam mengambil keputusan. Tujuan penelitian ini: pertama, menguji perbedaan persepsi etis terhadap praktik akuntansi kreatif pada mahasiswa. Kedua, untuk menguji pengaruh atribut individual yaitu moral disengagement pada persepsi etis. Pengumpulan data menggunakan kuesioner, dengan total responden berjumlah 225 dari 2 universitas berbasis keagamaan dan 1 universitas umum. Pengujian hipotesis menggunakan Analysis of Variance (ANOVA). Hasil penelitian menunjukkan: pertama, terdapat perbedaan signifikan persepsi etis antara mahasiswa di universitas berbasis keagamaan dan universitas umum. Mahasiswa di universitas berbasis keagamaan lebih menganggap akuntansi kreatif sebagai praktik yang etis di banding mahasiswa di universitas umum. Kedua, terdapat perbedaan persepsi etis individu yang memiliki moral disengagement tinggi dan rendah. Kata kunci: Persepsi etis, akuntansi kreatif, pendidikan etika, moral disengagement DOI: https://doi.org/10.24843/JIAB.2018. v13.i01. p03 The flexibility of accounting standards is one of the drivers of creative accounting. Creative accounting is an ethical dilemma. It seems that creative accounting does not explicitly violate the rules, but led misinterpretation and misdirection in user’s decisionmaking. The purposes of this study are, to test the differences of ethical perceptions of creative accounting of undergraduate students in religious and public universities; Second, to examine the effects of moral disengagement on ethical perceptions. The data collection method involved a questionnaire to a total of 225 respondents from two religious-based universities and one public university. Analysis of Variance (ANOVA) was used to test the hypothesis. The results show that there is a significant difference in students’ethical perceptions between public university and religious-based universities. Thus, there is a significant difference in students’ ethical perceptions students with high and low level moral disengagement. Educational implication and suggestion for future research are proposed.