Miracle-dz/UniFAR-FTUs huggingface dataset:
Apprentissage d'environnement : approches cognitives et comportementales

Nos travaux se concentrent sur l'apprentissage d'environnement qui est un moyen de rendre les systemes autonomes plus adaptatifs. Dans un premier temps, nous avons employe une approche cognitive qui a debouche sur une nouvelle methode pour la construction et la mise a jour d'un modele geometrique du monde. Partant de deux modeles assez frustres du monde, notre algorithme introduit une methodologie de fusion composee d'une suite d'operations simples. Notre methode aboutit a un modele du monde comparable, en precision et en robustesse, aux modeles classiquement construits par un fitrage numerique de Kalman. Notre approche est cependant plus flexible - il suffit par exemple d'utiliser des modeles de base differents - ce qui permet de concevoir des systemes plus autonomes. Neanmoins, seul un traitement de plus en plus complexe et specifique des informations manipulees par notre modele peut encore augmenter son utilite et son adaptabilite, ce qui, finalement, nuit au caractere autonome d'un robot. Nous pensons que cette critique se generalise a l'approche classique de la robotique mobile. Nous nous sommes donc tournes, dans un deuxieme temps, vers l'apprentissage de comportements. Pour cela, nous avons developpe un nouvel algorithme d'apprentissage par renforcement pour des problemes de decisions markoviens partiellement observes. Nous avons formalise le cadre applicatif de notre algorithme, c'est-a-dire l'observabilite d'ordre fini du processus markovien, puis nous l'avons valide par des simulations. Ces simulations montrent en outre sa robustesse sur des problemes sortant du cadre theorique de convergence.
ASEAN Tourism Destination: A Strategic Plan

This is a preliminary research to explore the construction of ASEAN tourism promotion via @goaseantv images for the period January until December 2016. This research shows the promotion activities from the regional destination management organization to develop the image of ASEAN tourism destination. These activities were observed from the marketing communication conducted via Twitter. Thr research conducted on a content analysis for each image posted on @goaseantv. These images were analyzed and categorized in reference to the image linked to the website or other social media. Images were categorized into the following types: whether the image was natural or edited, the number of the objects displayed, the type of view, the type of objects displayed, the number of humans displayed, the animal species displayed, the type of lodging and accommodation, the dominant color, the art and culture, the food, the souvenir, the country of origin, as well as the type of the activities displayed. A total of 255 photos were analyzed and the results show that the majority of the images uploaded to Facebook, displayed natural imagery rather than edited imagery, consisted of a single picture, the focus was on panoramic views, and most views displayed the sea.
Nonparathyroid humoral hypercalcemia in patients with neoplastic diseases.

Abstract Eleven patients had hypercalcemia and hypophosphatemia associated with various nonparathyroid neoplasms in the absence of bony metastases (pseudohyperparathyroidism). In nine patients surgical ablation or other antitumor therapy resulted in remission of the biochemical abnormalities. Parathyroid hormone was undetectable both in peripheral blood and in tumor tissue from all patients when assessed with multiple immunoassays that detect not only intact parathyroid hormone but proparathyroid hormone and biologically active and inactive parathyroid hormone fragments in addition. However, extracts of tissues caused active calcium resorption from bone in vitro. The chemical nature of the presumed humoral substance (or substances) is unknown. The findings suggest that in many patients with neoplasms and clinical and biochemical features typical of pseudohyperparathyroidism some humoral substance other than parathyroid hormone must be responsible for hypercalcemia and other features of their disease. (N E.
Technopreneur Based Entrepreneurship Development Program as an Effort to Realize the Nationality of Nations in Politeknik Negeri Batam

The Entrepreneurship Development Program (PPK) program is a place for students and alumnus in entrepreneurship. The Entrepreneurship Program implemented comes from the DRPM Ristek Dikti. The Entrepreneurship Development Program is a realization of the commitment of the Batam State Polytechnic in developing entrepreneurship. The Entrepreneurship Development Program at Batam State Polytechnic is an entrepreneurial program with the aim of producing new entrepreneurs who are independent based on science and technology. There is a series of activities in the process of recruiting tenants until the selection of candidates who have criteria has the right to participate in the program of entrepreneurship development. The method of implementing entrepreneurship development program activities through the Capacity Building with an approach in the context of empowering potential tenants using the PALS method (Participatory Action Learning System). The PALS method emphasizes the existing activities to be attempted to be brought to the condition of students through entrepreneurial awareness phase, capacity building and mentoring phase. The PALS method in the form of skills and management training is carried out with the aim of providing knowledge and understanding of entrepreneurship, encourage innovative ideas motivation, as well as to increase understanding in the management of business organization, the production of the operation, business financial, as well as making business and marketing business plan. The incubation activity in the Entrepreneurship Development Program received 41 candidates who were selected according to the criteria and then produced 25 tenants. At the end of the program the development of entrepreneurship has succeeded in producing new independent entrepreneurs who are ready to go to the community. Research paper Keywords: Science and technology, Entrepreneurship, Tenants, Capacity building, Business management, Skills Reference to this paper should be made as follows: Hati, S. W. , Hidayat, R. , Kartikaningdiyah, E. , & Gunawan, H. (2018). Technopreneur Based Entrepreneurship Development Program as an Effort to Realize the Nationality of Nations in Politeknik Negeri Batam, Journal of Entrepreneurship, Business and Economics , 6 (2), 101–114.
Impact of Human Capital Management Practices on Employees’ Job Performance

This paper aims to analyze the relationship between the human capital management (HCM) practices which include training and development, recruitment and selection, Performance appraisal and employee’s job performance in the telecom sector of Pakistan. To find the influence of HCM practices on employees job performance within telecom sector of Pakistan. This is a survey based research study. The sample of the study is employees’ who are working in public and private sector telecommunication companies in Pakistan. Data are collected through questionnaires. Sample size was (n=272); therefore, descriptive statistics, correlation and regression analysis have been used. The overall results support that HCM practices have prominent and indispensable role in the performance level of employees; knowledge and skill through training and development, compatibility & competence through recruitment and selection, confidence and morale through performance appraisal. HCM practices are highly correlated with each other and also correlated with employee’s job performance.
Skipped Spawning in Fishes: More Common than You Might Think

Abstract The traditional view of iteroparity in fishes is one of an annual reproductive cycle that culminates each year in spawning. More recently, a more flexible view of fish reproduction has been adopted, including the potential for mature fish to skip spawning. Here, we review the abundance of recent research on skipped spawning, covering a broad range of fishes with diverse life history strategies. Evidence for skipped spawning has been collected by use of traditional histological techniques as well as modern technological advances, such as satellite tags and the ability to track fish movements based on elemental and isotope signatures. Skipped spawning is most commonly attributed to deficient diet and poor nutritional condition. Advances made in this field of study in recent years include descriptions of hormonal changes that precede and perhaps initiate skipped spawning, the development of life history models that incorporate the potential for skipped spawning, and estimates of the degree to which skipped spawning influences the reproductive potential of fish populations. In addition to summarizing this new research, we attempt to advance current knowledge by (1) providing the first review discussion of skipped spawning in males, (2) exploring skipped spawning in anadromous fishes by using the Atlantic salmon Salmo salar as an example, and (3) discussing the potential for and difficulties in identifying skipped spawning in species with indeterminate fecundity.
FK506-binding proteins 12 and 12.6 (FKBPs) as regulators of cardiac Ryanodine Receptors: Insights from new functional and structural knowledge

ABSTRACT Ryanodine Receptors (RyRs) are intracellular Ca2+ channels that mediate Ca2+ flux from the sarco(endo)plasmic reticulum in many cell types. The interaction of RyRs with FK506-binding proteins (FKBPs) has been proposed as an important regulatory mechanism, where the loss of this interaction leads to channel dysfunction. In the heart, phosphorylation of RyR has been suggested to disrupt the RyR-FKBP interaction promoting altered Ca2+ signaling, heart failure and arrhythmias. However, the functional result of FKBP interaction with RyR and how this interaction is regulated remains highly controversial. Recently, high resolution structures of RyR have provided novel aspects to the ongoing debate. This review will discuss the most recent functional data in light of these new structures.
Axonal stratification patterns and glutamate‐gated conductance mechanisms in zebrafish retinal bipolar cells

1 Whole‐cell patch recording and puff pipette techniques were used to identify glutamate receptor mechanisms on bipolar cell (BC) dendrites in the zebrafish retinal slice. Recorded neurons were stained with Lucifer Yellow, to correlate glutamate responses with BC morphology. 2 BC axon terminals (ATs) consisted of swellings or varicosities along the axon, as well as at its end. AT stratification patterns identified three regions in the inner plexiform layer (IPL): a thick sublamina a, with three bands of ATs, a narrow terminal‐free zone in the mid‐IPL, and a thin sublamina b, with two bands of ATs. BCs occurred with ATs restricted to sublamina a(Group a), sublamina b(Group b) or with ATs in both sublaminae (Group a/b). 3 OFF‐BCs belonged to Group aor Group a/b. These cells responded to glutamate or kainate with a CNQX‐sensitive conductance increase. Reversal potential (Erev) ranged from ‐0.6 to +18 mV. Bipolar cells stimulated sequentially with both kainate and glutamate revealed a population of glutamate‐insensitive, kainate‐sensitive cells in addition to cells sensitive to both agonists. 4 ON‐BCs responded to glutamate via one of three mechanisms: (a) a conductance decrease with Erev≈ 0 mV, mimicked by L‐(+)‐2‐amino‐4‐phosphonobutyric acid (APB) or trans‐1‐amino‐1,3‐cyclopentanedicarboxylic acid (trans‐ACPD), (b) a glutamate‐gated chloride conductance increase (IGlu‐like) characterized by Erev≥ECl (where ECl is the chloride equilibrium potential) and partial blockade by extracellular Li+/Na+ substitution or (c) the activation of both APB and chloride mechanisms simultaneously to produce a response with outward currents at all holding potentials. APB‐like responses were found only among BCs in Group b, with a single AT ramifying deep within sublamina b; whereas, cells expressing IGlu‐like currents had one or more ATs, and occurred within Groups b or a/b. 5 Multistratified cells (Group a/b) were common and occurred with either ON‐ or OFF‐BC physiology. OFF‐BCs typically had one or more ATs in sublamina a and only one AT in sublamina b. In contrast, multistratified ON‐BCs had one or more ATs in sublamina b and a single AT ramifying deep in sublamina a. Multistratified ON‐BCs expressed the IGlu‐like mechanism only. 6 Visual processing in the zebrafish retina involves at least 13 BC types. Some of these BCs have ATs in both the ON‐ and OFF‐sublaminae, suggesting a significant role for ON‐ and OFF‐inputs throughout the IPL.
Relationship between job stress, temperament and depressive symptoms in female nurses

ObjectivesA casual relationship between temperament, job stress and depressive symptoms has not been established yet. The purpose of this study was to assess the relationships between job stress, temperament and depressive symptoms in female nurses at a Japanese general hospital.Material and MethodsA self-report survey was conducted among 706 nurses. We measured job stress, temperament, and depressive symptoms using the Brief-Job Stress Questionnaire, the TEMPS-A and a screening scale of items from the Ministry of Health, Labour and Welfare of Japan. In order to examine the causal relationship between the measures the stepwise multiple regression and path analyses were used. Results: Depressive symptoms were modestly correlated with job stress (γ = −0.23–0.30). Except for hyperthymic temperament measures, the correlations between depressive symptoms and temperament types were significant and moderate (γ = 0.36–0.50). Overtime, job control as well as depressive and cyclothymic types of temperament were significantly correlated with depressive symptoms (β = 0.15, p < 0.05; β = 0.19, p < 0.01; β = 0.26, p < 0.001; β = 0.32, p < 0.001, respectively). Path-analysis revealed that depressive and cyclothymic types of temperament influenced depressive symptoms both directly (β = 0.67, p < 0.001) and indirectly via job stress (β = 0.35, p < 0.001 from temperament to job stress; β = 0.20, p < 0.05 from job stress to depressive symptoms). Irritable and anxious types of temperament and quantitative job overload did not contribute to the path-analytic model.ConclusionsHealth care professionals should consider temperament, especially depressive and cyclothymic types, in order to help employees cope better with job stress factors. We need further research about the effective intervention to help employees better cope with their job stress.
Increased driving accident frequency in Danish patients with epilepsy

Objective: To determine driving accident frequency in a cohort of patients with epilepsy. Methods: A 10-year historical cohort register study of 159 subjects with epilepsy and 559 controls individually matched for age, gender, place of residence, and exposure period was carried out. All had nonprofessional driver’s licenses without restrictions. Persons with recorded diagnoses of other neurologic diseases, diabetes, psychoses, seizures, abuse, or poisoning of any kind were not included. The outcome measure was treatment at the casualty department after an accident as a car driver. Results: Ten patients with epilepsy and five controls had been treated at the casualty department, the rate per 1,000 person-years with exposure being seven times higher (CI 2.18 to 26.13) in those with epilepsy than in the control cohort. Conclusions: Drivers with epilepsy are more likely than healthy controls to be treated at a casualty department after having a motor vehicle accident.
Elevated copper in the amyloid plaques and iron in the cortex are observed in mouse models of Alzheimer's disease that exhibit neurodegeneration.

BACKGROUND In Alzheimer's disease (AD), alterations in metal homeostasis, including the accumulation of metal ions in the plaques and an increase of iron in the cortex, have been well documented but the mechanisms involved are poorly understood. OBJECTIVE In this study, we compared the metal content in the plaques and the iron speciation in the cortex of three mouse models, two of which show neurodegeneration (5xFAD and Tg-SwDI/NOS2-/- (CVN) and one that shows very little neurodegeneration (PSAPP). METHODS The Fe, Cu, and Zn contents and speciation were determined using synchrotron X-ray fluorescence microscopy (XFM) and X-ray absorption spectroscopy (XAS), respectively. RESULTS In the mouse models with reported significant neurodegeneration, we found that plaques contained ~25% more copper compared to the PSAPP mice. The iron content in the cortex increased at the late stage of the disease in all mouse models, but iron speciation remains unchanged. CONCLUSIONS The elevation of copper in the plaques and iron in the cortex is associated with AD severity, suggesting that these redox-active metal ions may be inducing oxidative damage and directly influencing neurodegeneration.
The long sea level record at Cadiz (southern Spain) from 1880 to 2009

[1] Mean sea level observations from an historical tide gauge located in Cadiz (Southern Spain) spanning the period 1880–1924 were recovered from national archives. Daily sea level averages stored in handwritten log books were digitized, quality controlled, and referred to the same benchmark. A careful analysis of all the high precision leveling surveys available in the area of the tide gauge enabled the establishment of a common datum with a modern record starting in 1961 from another tide gauge located only 2.5 km apart, with accuracy better than 5 mm. As a result, a consistent daily mean sea level record from 1880 to 2009 was constructed. The 20th century relative mean sea level rise in Cadiz is 0.7 ± 0.1 mm yr−1, which becomes 1.0 ± 0.2 mm yr−1 once corrected for vertical land movement with high precision GPS data, in agreement with nearby records. The analysis of the seasonal sea level cycle indicated that the amplitude of the annual cycle has increased during the 20th century. This work evidences the significance of sea level data rescue for present-day climate research.
Use of Estrogens among Middle-Aged Massachusetts Women

This study describes estrogen use among 45- to 55-year-old white women in Massachusetts from 1981 to 1987. In a 1981 cross-sectional survey, 7705 white women (77 percent response rate) returned a questionnaire or were interviewed by phone. Premenopausal women were invited into a 4.5-year follow-up study including telephone interviews every nine months, and 2236 (approximately 91 percent of the eligible women) had a complete follow-up. In the cross-sectional survey, 7.9 percent had used oral estrogens in the last two weeks, but most (77 percent) had had a hysterectomy; use varied notably from one area to another. Vaginal estrogens were used by 2.9 percent. Users and nonusers of oral estrogens were quite similar in regard to sociodemographic background. Data from the follow-up surveys showed that estrogen use increased throughout the study period and by the final follow-up women with higher education status reported more estrogen use than those with lower education status. Most women used estrogens only for a short time.
Relationship of preoperative serum CA-125 to survival in epithelial ovarian carcinoma.

BACKGROUND Epithelial carcinoma of the ovary has the highest death rate of any gynecologic malignancy in the developed world. The antigen CA-125 has been used over the past decade as a tumor marker for epithelial ovarian cancer and other cancers of coelomic epithelium. The object of this study was to see if the degree of elevation of preoperative CA-125 was related to length of survival in patients with epithelial ovarian carcinoma. METHODS Eighty-two consecutive patients diagnosed with epithelial ovarian carcinoma were evaluated for their initial preoperative CA-125 level, time to recurrence, length of survival and level of primary debulking as well as International Federation of Gynecologists and Obstetricians stage, grade and histology. Ovarian tumors of low malignant potential were not included in the study. All patients had their initial surgery performed by one surgeon. RESULTS Decreased length of survival was related to the degree of elevation of CA-125 prior to initial exploratory laparotomy (P = .047). The mean initial CA-125 for patients surviving five years or more (15 patients) was 899 U/mL, with an SD of +/- 1,880 U/mL, while the CA-125 for patients surviving less than five years (67 patients) was 1,978 U/mL, with an SD of +/- 1,852 U/mL (P = .02). Increased stage of disease at initial laparotomy showed a relationship to increased CA-125 (P < .0001). CONCLUSION In epithelial ovarian carcinoma, high preoperative serum levels of CA-125 predict decreased length of survival.
The Impact Of Place-Based Determinants Of Health On Utilization Of Emergency Department Services

The purpose of the study is to investigate whether higher prevalence of place-based structural determinants of health inequity is directly associated with frequent utilization of services in the emergency department. Chi-square and t-test analyses found that compared to non-frequent ED users, frequent ED users were older (mean age 43.18 vs. 35.23, p<0.001), more commonly Black or African American (65.13% vs. 52.36%, p<0.001), more commonly covered by public insurance [Medicaid (50.62% vs. 36.66%, p<0.001) or Medicare (15.45% vs. 11.41%, p<0.001)] and more commonly unemployed (41.04% vs. 33.09%, p<0.001). Multivariate logistic regression analysis demonstrated that several person-level factors, age of sixty years and older (OR: 3.57; CI [3.38-3.77]), female gender (OR: 1.40; CI [1.32-1.48]), and history of chronic pain (OR: 1.30; CI [1.13-1.50]) significantly increased the likelihood of being diagnosed in the ED with an ACSC (Table 9). Finally, multivariate logistic regression analysis also demonstrated that both person-level factors—homelessness (OR: 3.74; CI [2.35-5.95]), history of abuse (OR: 1.79; CI [1.54-2.09]), and history of substance use disorder (OR: 1.53; CI [1.371.69])—and place-level factors with housing instability (1.36; CI [1.33-1.39]) were associated with frequent ED utilization. Using multilevel analysis, compared to within census tracts, the variance between census tracts was found to be greater (3.29 vs. 0.046). In conclusion, there is some evidence that residing in an area with greater prevalence of a social need domain, specifically housing instability, is associated with increased utilization of ED services. Acknowledgements The student author of this thesis is grateful for all the guidance and support provided by both faculty and community mentors. She is thankful for the time of Mark Abraham, Executive Director of DataHaven, who expressed faith in this project and its potential to inform subsequent initiatives in community-based interventions targeting structural determinants of health in the Greater New Haven area. She is also appreciative of the unwavering optimism and patience provided by Elizabeth Samuels, MD, MPH from the conception of this project. The author is grateful for the guidance and time of her thesis advisor, Brita Roy, MD, MPH, MHS, throughout the entire process of working on this thesis. Research reported in this publication was supported by National Heart, Lung And Blood Institute of the National Institutes of Health. The content is solely the responsibility of the author’s and does not necessarily represent the official views of the National Heart, Lung, and Blood Institute or the National Institutes of Health under Award Number T35HL007649. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Table of