Miracle-dz/UniFAR-FTUs huggingface dataset:
Crosstalk between Cytokine RANKL and AhR Signalling in Osteoclasts Controls Bone Homeostasis

The aryl hydrocarbon receptor (AhR), which acts as a transcription factor when bound by a ligand, regulates a variety of physiological processes, most notably cellular activities related to immune responsivity. Observations of disrupted bone tissue healing and slowed endochondral ossification in AhR−/− mice indicate strongly that AhR also modulates skeletal remodeling, though the signaling mechanism through which AhR affects osteoclastogenesis remains to be resolved. Recent studies have shown that receptor activator of nuclear factor kappa-B ligand (RANKL) causes rapid upregulation of AhR expression in bone marrow-derived osteoclasts. Ligand activated AhR by the smoke toxin BaP increased osteoclast differentiation in a receptor AhR-dependent manner. Mitochondrial biogenesis in osteoclasts is subject to regulation by AhR. AhR involvement in osteoclastogenesis makes AhR a potential therapeutic target for the treatment of inflammatory and metabolic bone diseases. The present review highlights the recently uncovered critical role that RANKL–AhR–c-Fos signaling plays in osteoclastogenesis.
Multiporosity flow in fractured low‐permeability rocks

A multiporosity extension of classical double and triple‐porosity fractured rock flow models for slightly compressible fluids is presented. The multiporosity model is an adaptation of the multirate solute transport model of Haggerty and Gorelick (1995) to viscous flow in fractured rock reservoirs. It is a generalization of both pseudo steady state and transient interporosity flow double‐porosity models. The model includes a fracture continuum and an overlapping distribution of multiple rock matrix continua, whose fracture‐matrix exchange coefficients are specified through a discrete probability mass function. Semianalytical cylindrically symmetric solutions to the multiporosity mathematical model are developed using the Laplace transform to illustrate its behavior. The multiporosity model presented here is conceptually simple, yet flexible enough to simulate common conceptualizations of double and triple‐porosity flow. This combination of generality and simplicity makes the multiporosity model a good choice for flow modelling in low‐permeability fractured rocks.
Imaging the Dead Sea Transform with scattered seismic waves

SUMMARY With controlled seismic sources and specifically designed receiver arrays, we image a subvertical boundary between two lithological blocks at the Arava Fault (AF) in the Middle East. The AF is the main strike-slip fault of the Dead Sea Transform (DST) in the segment between the Dead Sea and the Red Sea. Our imaging (migration) method is based on array beamforming and coherence analysis of P to P scattered seismic phases. We use a 1-D background velocity model and the direct P arrival as a reference phase. Careful resolution testing is necessary, because the target volume is irregularly sampled by rays. A spread function describing energy dispersion at localized point scatterers and synthetic calculations for large planar structures provides estimates of the resolution of the images. We resolve a 7 km long steeply dipping reflector offset roughly 1 km from the surface trace of the AF. The reflector can be imaged from about 1 km down to 4 km depth. Previous and ongoing studies in this region have shown a strong contrast across the fault: low seismic velocities and electrical resistivities to the west and high velocities and resistivities to the east of it. We therefore suggest that the imaged reflector marks the contrast between young sedimentary fill in the west and Precambrian rocks in the east. If correct, the boundary between the two blocks is offset about 1 km east of the current surface trace of the AF.
Male Partner Participation in Preventing Mother-to-Child Transmission of Human-Immunodeficiency Virus (PMCHT) and its Predictive Factors in Bishoftu, Central Ethiopia

Background & aim: Globally, human-immunodeficiency virus (HIV) is threating the lives of human being. Despite the several programs supporting male partner involvement in the prevention of mother-to-child HIV transmission (PMCHT), only few male partners have accepted and involved in this process. Regarding this, the present study aimed to assess male partner involvement in the PMCHT and its associated factors in Bishoftu, Central Ethiopia Methods: This cross-sectional study was conducted on 405 male partners whose mates gave birth in Bishoftu during June, 2016. The study population was selected using simple random sampling technique. Data collection was performed by means of a self-administered interview questionnaire. The data were analyzed in SPSS software (version 20) using Chi-square test and t-test. P-value less than 0.05 was considered statistically significant. Results: A total of 405 male partners participated in this study with a response rate of 96.2%. The mean age of the participants was 34.03±5.8 years. Spousal participation index in the PMCHT service in Bishoftu town was obtained as 211 (52.1%). The significant predictors of male partner participation in the PMCHT programs included low knowledge about PMCHT services (adjusted odds ratio [AOR]=2.27, 95% CI: 1.12-4.57), negative attitude towards these programs (AOR=2.09, 95% CI: 1.23-3.67), unawareness about the provision of PMCHT services in the public health facilities (AOR=2.41, 95% CI: 1.27-4.95), and perceiving attending antenatal care and PMCHT program as only women’s responsibility (AOR=3.96, 95% CI: 2.00-7.81). Conclusion: As the findings indicated, male partner participation in the PMCHT service was not at a satisfactory level. Consequently, it is highly recommended to equip the male partners with knowledge, as well as positive attitude and perception towards these services.
Application of stakeholder theory to corporate environmental disclosures

Ullmann's (1985) three-dimensional model of social responsibility disclosure is tested to determine whether it can be operationalized to help explain the quantity and quality of environmental disclosures in Australian annual reports. The stakeholder power dimension of Ullmann's framework is significant in explaining environmental disclosures while content of the mission statement and existence or otherwise of environmental or social responsibility committees also find strong statistically significant support in the results. Ullmanns' stakeholder theory has previously been applied to explain social disclosures in general (Roberts, 1992) and is an important theory because it introduces a measure of strategy. The current paper demonstrates how this theory can be applied to a specific social disclosure using variables that are idiosyncratically applicable to the types of disclosures.
Evidence that the AGN dominates the radio emission in z ~ 1 radio-quiet quasars

This document is the Accepted Manuscript version of the following article: Sarah V. White, Matt J. Jarvis, Eleni Kalfoutnzou, Martin J. Hardcastle, Aprajita Verma, Mose M. Cao Orjales, and Jason Stevens, 'Evidence that the AGN dominates the radio emission in z ~ 1 radio quiet quasars', Monthly Notices of the Royal Astronomical Society, first published online 3 February 2017, DOI: https://doi.org/10.1093/mnras/stx284 Key results are presented in Table 4 and Figure 7, which illustrates where the RQQs lie in relation to the far-infrared--radio correlation © 2017 The Authors. Published by Oxford University Press on behalf of the Royal Astronomical Society.
Stacking Faults in Kaolin-Group Minerals in the Light of Real Structural Features

A comparison of the structural characteristics of the kaolin-group minerals, mainly kaolinite and dickite, shows that they differ in both the two-dimensional periodicity in the 1:1 layers and the rotation angles of the polyhedra. Distortions in a real 1:1 layer, compared with an idealized layer, do not allow such stacking faults as ± 120° layer rotations and vacancy displacements, because the second layer is incommensurable with the first. The 1:1 layer structure and the fact that the unit cell is symmetrical with respect to the plane passing through the long diagonal of the unit cell suggest the possibility of defects resulting from the two stacking sequences for the same layers. For a regular alternation of translations, a halloysite-like structure should be the end-member of such a series of defect kaolinite types.The formation of layers having vacant octahedral C-sites is another possible type of fault. Because of the minor dilference between γ and 90°, dickite-like layers should exist. A regular alternation of B and C layers yields dickite as the end-member structure. In materials containing few defects, stacking faults of both types lead to similar X-ray powder diffraction patterns. Thus, the nature of the stacking faults is difficult to determine experimentally. In materials containing many defects, however, the two models lead to different calculated diffraction patterns. Therefore, only a study of defect-rich types of kaolinite can determine which types of defects exist in natural kaolinite samples. РезюмеСравнение структурных характеристик минералов каолиновой группы, в основном као- линита и диккита, показало, что они различаются как в отношении двумерной периодичности их 1: 1 слоев, так и углами разворота полиэдров. Искожения реальных 1:1 слоев по сравнению с идеали- зированными не позволяют реализоваться таким дефектам упаковки, как вращние на ± 120° и смена положения вакансии, поскольку второй слой сказался бы несоразмерным с первым. Строение 1:1 слоя и элементарной ячейки, будучи симметричны относительно плоскости, проходящей через длин- ную диагональ элементарной ячейки, предопределяют возможность возникновения дефектов упа- ковки, вызванных двумя способами наложения однотипных смежных слоев, в случае их регулярного чередования конечным членом такого ряда дефектных каолинитов была бы структура галлуазитового типа. Возникновение слоев с вакантной с позицией представляется другим допустимым типом ошибок. Вследствие малого отклонения угла гамма от 90° могли бы встречаться диккито-подобные встройки, давая при упорядоченном чередовании слоев в и с диккит как конечный член ряда, в образцах с низкми содержанием дефектов оба типа ошибок приводят к близкому профилю рентгеновской ди- фракции и природу ошибок экспериментально установить сложно, в образцах с высокой концентра- цией дефектов две модели ведут к различным дифракционным картинам, поэтому изучение сильно дефетных каолинитов может ответить на вопрос, какой тип дефектов встречается в природный образ- цах.
GLUTENIN COMPOSITION OF WINTER WHEAT VARIETIES BRED IN DOBRUDZHA AGRICULTURAL INSTITUTE

ATANASOVA, D. , N. TSENOV, I. TODOROV and I. IVANOVA, 2009. Glutenin composition of winter wheat varieties bred in Dobrudzha agricultural institute. Bulg. J. Agric. Sci., 15: 9-19 A total of 70 bread wheat varieties bred in Dobrudzha Agricultural Institute (DAI), Bulgaria were characterized for the composition of high-molecular-weight and low-molecular-weight glutenin subunits (HMW-GS and LMW-GS, respectively) using SDS-PAGE. Twenty-five different HMW-GS patterns were observed. The most frequent combination was 2*, 7+9, 5+10 (23.76%) and N, 7+9, 5+10 (14.85%). Twenty-eight different LMW-GS patterns were established as Glu-A3c, Glu-B3b, Glu-D3c and Glu-A3e, Glu-B3b, Glu-D3c being the most frequent. The average Glu-score of the investigated wheat varieties was comparatively high (8.0). One of the reasons for the high score was the gradually removing of subunit 2+12 at locus Glu-D1, which effect on bread making quality was negative. The potential of locus Glu-D1 was still unused for improving end-use quality of wheat and for broadening the genetic diversity of germplasm. The established database describing the HMW and LMW-GS of DAI bread wheat varieties may be useful for breeders who want to use Bulgarian germplasm in their breeding programs.
Evaluation of single-kernel density of scab-damaged winter wheat

Evaluation of single-kernel density of scab-damaged winter wheat Measurements of single-kernel mass and volume made on healthy (control) and scab-damaged samples of grain of three winter wheat varieties never resulted in lower values of mean single-kernel density for scab-damaged grain. This finding, contrary to common opinion, can be explained as being a result of the comparable magnitude of relative decrease (due to infestation) of two features (mass and volume) that define single-kernel density. The discrepancy between results presented in this paper (kernel volume was determined with an air pycnometer) and the results in some other reports (liquid pycnometers used) can result from the different methods applied for kernel volume measurements: when a liquid medium is used the surface tension effect tends to overestimate the volume, especially for scabby kernels that are known to be shrivelled ie possessing voids and pores at the surface that the liquid cannot penetrate. As a consequence kernel density of scabby kernels can be significantly underestimated.
The human follicle stimulating hormone (hFSH) keeps the normal ultrastructure of caprine preantral follicles cultured in vitro

O objetivo desse estudo foi investigar os efeitos do FSH humano (hFSH) no cultivo in vitro de foliculos pre-antrais caprinos. Fragmentos do cortex ovariano de caprinos foram cultivados em ? -MEM+ suplementado com 0, 10, ou 50 ng/mL de hFSH por um ou sete dias. Pequenos fragmentos de tecido ovariano cultivado e nao cultivados, foram processados por histologia classica e microscopia eletronica de transmissao. Os testes estatisticos utilizados na pesquisa foram Lilliefors, Cochran, e Tukey’s (caso significância - PROC ANOVA; SAS). Os resultados mostraram uma reducao no percentual de foliculos normais, apos um ou sete dias de cultivo em todas as condicoes de tratamento. As taxas de sobrevivencia folicular foram semelhantes entre si, dentro de cada dia de cultivo. O meio contendo 10 ng/mL de hFSH reduziu a percentagem de foliculos primordiais no dia um e sete de cultivo, e nao aumentou a percentagem dos foliculos em desenvolvimento. O diâmetro folicular de tecido ovariano cultivado em meio ? -MEM+ e meio suplementado com 10 ng/mL de hFSH nao alterou, quando comparado com o controle (nao cultivado). As analises ultraestruturais confirmaram a integridade de foliculos cultivados por sete dias em meio contendo 10 ng/mL de hFSH. Em conclusao, o hFSH (10 ng/mL) e capaz de promover a ativacao de foliculos primordiais e manter a integridade ultraestrutural de foliculos preantrais caprinos cultivados in vitro por ate sete dias.
A NEW METHOD FOR THE DETERMINATION OF [ H 3 O + ] ION IN ORGANIC ACIDS VIA 532 NM SOLID STATE LASER DIODE WITH CONTINUOUS FLOW INJECTION

The new method is rapid, sensitive and simple for the determination of Hydronium ion in organic acids using 532nm solid state laser diode with continuous flow injection analysis and using laser dye (Rhodamine6G) as a fluorescent host . The method was based on quenching of fluorescence for Rhodamine6G via organic acid. A liner range of organic acid was 7-2000mMol.L-1forascorbic acid (C6H8O6),7-1000mMol.Lfor tartaric acid (C4H6O6)and 10-1800mMol.L-1for citric acid(C6H8O7),with correlation coefficient r= 0.9758, 0.9756 and 0.9802, successively the limit of detection(LOD)was323.356,344.450and 352. 732μg/sample based on gradual dilution of lowest concentration in calibration graph. The new method can be accepted as an alternative analytical method.
International Journal of Human Capital Management, Vol. 2 (2), December 2018

This study examined the effect of conflict on employee output, absenteeism and turnover. The study was quantitative, and the design was a descriptive survey. The population for the study was stratified, and the study participants were selected randomly. The instrument was a questionnaire, and the IBM SPSS version 22 was used to generate the results for discussion. The study revealed that conflict adversely influences employee performance and accounts for frequent absenteeism, low output and turnover. One implication for leadership from the study is that workplace conflicts significantly affect employee output, absenteeism and turnover. Each employee faces different conflicts that must be understood and resolved. By implication, organisational leaders must design jobs appropriately for employees to prevent duplications and foster peaceful collaboration among employees. This will help them build trust among themselves at the workplace. This will reduce interpersonal, relationship and task-related conflicts within the organisation. This will also minimise conflict and its dysfunctional consequences on the employees and the organisation. Literature on the conflict in higher institutions appears to be scarce in Ghana. This study is different as it examines the relationship between conflict and employee performance using work output, absenteeism and turnover in technical universities in Ghana.
Studies on Phytocides II. Tests of Chlorinated Aryloxymethylphosphonous and Phosphonic Acids As Poisons and Auxins

Tests were made on pea epicotyls or oat coleoptiles with o-chloro-, p-chloro-, 2,4-dichloro-, and 2,4,5-trichlorophenoxymethylphosphonous acids. The first compound behaved like a weak auxin, the third like an inactive substance or antiauxin (depending on the test), and the remainder like anti-auxins. The compounds usually showed some toxicity, which was far less than that of the corresponding carboxylic acids.
Ambivalent Professionalisation and Autonomy in Workers’ Collective Projects: The Cases of Sex Worker Peer Educators in Germany and Sexual Assistants in Switzerland

Drawing on participant methodologies this article examines two cases of workers’ self-organised projects oriented to improving the quality of sex work and to ‘professionalisation’. The first case is a group of sexual assistants for people with disabilities, who have organised meetings and training for sexual assistants in a medium-sized city in Switzerland. The second is a group of peer sex worker educators offering workshops to people who sell sex in various industry sectors in a large German city. We argue that these activist interventions may represent a resource for identifying crucial aspects of work-quality and professionalisation in sex work and for making sense of some apparent contradictions of sex workers’ organising. Indeed, through ongoing conversations and recommendations about working practices and ethics, our participants develop situated views of what is better sex work and they originally engage with key conceptual areas, such as consent, autonomy, standardisation, income and professional identity. They do so by comparing a variety of experiences in sex industries, as well as discussing similarities with other jobs such as body work, care work, and psychotherapy.
Synthesis, characterization, thermal behavior, and biological activity of ozonides from vegetable oils

In this work, we have synthesized ozonides from sunflower, flaxseed and baru oils. In addition, ozonolysis reaction of sunflower oil in the presence of water was performed, and the product obtained had high viscosity and a gel-like appearance. The ozonated products were investigated for their antimicrobial activity and cytotoxicity. The oleogel, with an MIC ≤ 3 mg mL−1, exhibited excellent antimicrobial activity against standard and clinical strains. All products showed no cytotoxicity when tested against NIH/3T3 murine fibroblast cells. Effects of ozonation time on the oils were analyzed by IR, 1H and 13C NMR spectroscopy. DSC analysis shows that the ozonides of vegetable oils decompose with a peak at about 150 °C and with a broad exotherm. The decomposition enthalpy is proportional to the degree of ozonation reached.
Vacuum-Cavitation Therapy Versus Liposuction on Lipoedema in Female

This study had been conducted to evaluate the efficacy of the vacuum-cavitation therapy versus liposuction on lipoedema in female. Methods of evaluation (Measurement of the thigh circumference and thigh skin fold), Forty female patients with lipoedema in their thighs, were divided into two groups. Group (A) received the vacuum-cavitation therapy in addition to the routine medical and nursing care as well as the routine physical therapy. Group (B) underwent liposuction in addition to the routine medical and nursing care as well as the routine physical therapy; Measurements were conducted before starting the treatment as a first record and at the end of the third month of treatment as a second (final) record. Results showed that both vacuumcavitation therapy and liposuction were effective but vacuum-cavitation therapy was more fruitful and beneficial in decreasing lipoedema in females.
OTT_A_206180 7993..8002

Department of Breast and Thyroid Surgery, Affiliated Jining No. 1 People’s Hospital of Jining Medical University, Jining Medical University, Jining, Shandong 272011, People’s Republic of China Background/purpose: Cell adhesion molecule 1 (CADM1) functions as a tumor suppressor and has been identified to be frequently inactivated in breast cancer, and closely associated with patients’ poor prognosis and advanced TNM stage. However, the mechanisms underlying CADM1 in breast cancer progression remains incompletely clear. miR-155, a predicted modulator of CADM1 was reported to be overexpressed in breast cancer, and its high expression level was closely related to the malignant progression of breast cancer. The present study aimed to explore whether miR-155-3p could modulate CADM1 expression and then involved in the progression of breast cancer. Methods: The expression patterns of miR-155-3p in breast cancer tissues and cell lines were determined by RT-PCR technology. The relationship between CADM1 and miR-155-3p were determined by the luciferase gene reporter and Western Blot (WB) assays. Cell proliferation, apoptosis rates and tumorigenesis were determined by CCK-8, flow cytometry and in vivo xenotransplanation experiments, respectively. Results: miR-155-3p was up-regulated in breast cancer tissues and cells when compared to the adjacent normal tissues and normal breast MCF 10A cells. The mRNA and protein levels of CADM1 showed opposite expression patterns to that of miR-155-3p expression detected, and miR-155-3p could negatively regulate CADM1 expression in breast cancer MCF-7 cells. Moreover, gain-of function assay showed that overexpression of miR-155-3p promoted cell proliferation, tumorigenesis and repressed cell apoptosis, but these effects were all significantly impaired when the cells were simultaneously transfected with OE-CADM1, the overexpressing vector of CADM1. Conclusion: This study revealed that miR-155-3p could accelerate the progression of breast cancer via down-regulation of CADM1 expression.