Miracle-dz/UniFAR-FTUs huggingface dataset:
Interessante Weberknechtfunde aus Polen (Arachnida: Opiliones).

Interesting records of Polish harvestmen (Arachnida: Opiliones). Many new localities for Polish harvestmen are recorded, specifically for species whose ranges do not encompass the whole country. Opilio canestrinii is recorded for the first time in Poland. key words: Arachnida, Opiliones, Poland, faunistics, new records, Opilio canestrinii Seit Erscheinen meiner Monographie der polnischen Weberknechte (STARĘGA 1976) haben sich viele neue Informationen uber deren Verbreitung und Umweltanspruche ergeben. Diese wurden teilweise schon publiziert (STARĘGA 1979, 2001, JĘDRYCZKOWSKI & STARĘGA 1980, CZECHOWSKI et al. 1981, SANOCKA-WOŁOSZYNOWA 1981, SANOCKA 1983, RAFALSKI 1985, SANOCKA & OŚŁIZLO 1986, JĘDRYCZKOWSKI 1995, 1996, ŁĘGOWSKI 1995), andere Daten werden hier erstmals veroffentlicht. Es sind vor allem Angaben uber Arten, die nicht im ganzen Land vorkommen (oder nicht aus dem ganzen Land bekannt sind), uber seltene Arten und letzten Endes uber Opilio canestrinii, der bisher aus Polen „offiziell” nicht bekannt war (zwar von RAFALSKI & STARĘGA 1997 genannt, doch ohne Einzelheiten). Erwahnenswert ist auch die unveroffentlichte Diplomarbeit von OSTRZYCKA (1977), die viele Verbreitungsangaben enthalt von denen hier nur einige zitiert werden konnen. Sofern nicht anders angegeben, handelt es sich um Funde des Autors. Die Belegexemplare befinden sich in folgenden Institutionen: Museum und Institut fur Zoologie der PadW – Warszawa, Institut fur Biologie, Akademia Podlaska – Siedlce, Senckenberg-Museum – Frankfurt/Main und in der Privatsammlung des Verfassers. Alle Fundorte sind mit Koordinaten des UTM-Systems versehen [s. Appendix].
“Good” Firms, Worker Flows, and Local Productivity

This paper is the first to present direct evidence showing how localized knowledge spillovers arise from workers changing jobs within the same local labor market. Using a unique data set combining Social Security earnings records and balance sheet information for the Veneto region of Italy, I first identify a set of highly productive firms, then show that hiring workers with experience at these firms significantly increases the productivity of other firms. My findings imply that worker flows explain around 10% of the productivity gains experienced by incumbent firms when new highly productive firms are added to a local labor market.
Dysarthria and orofacial apraxia in corticobasal degeneration

The authors evaluated dysarthria and orofacial apraxia (OFA) in 10 patients with a clinical diagnosis of corticobasal degeneration (CBD). Nine patients were slightly dysarthric according to the French version of the Frenchay Dysarthria Assessment, which evaluates the motricity of the components of the vocal tract. The severity of dysarthria assessed by an intelligibility score was correlated to the global severity of the disease, but not to the duration of the disease. Voluntary movements of the tongue and the lips were impaired in all patients. OFA, evaluated with simple and sequential gestures, was present in nine patients. Sequential gestures were more frequently impaired. The score of OFA was not correlated to the severity of dysarthria, suggesting independent underlying mechanisms. Thus, when specifically assessed, dysarthria and OFA are more frequent in CBD than usually reported. We propose that the underlying pathophysiology is the result of a deficit in programming and execution of repetitive movements.
Enhanced Proton Conductivity of Graphene Oxide/Nafion Composite Material in Humidity Sensing Application

In this work, we report the performance of graphene oxide (GO) and Nafion composite as highly responsive humidity sensor. GO was synthesized using modified Hummers and Offeman method and was mixed with Nafion ionomer. The hybrid sensing layer was characterized using atomic force microscopy, field emission scanning electron microscopy, energy dispersive X-ray analysis and Fourier transform infrared spectroscopy. GO/Nafion composite solution was drop-casted on patterned gold electrodes on Si/SiO2 substrate to fabricate the sensor. GO/Nafion-based sensor was exposed to six different humidity level (40%-88%) and large response was obtained due to high proton conductivity of GO and Nafion. The sensor response varied from ~1400 times (40% RH) to ~18 000 times (88% RH). Our GO/Nafion based humidity sensor also exhibited very fast response and recovery times with excellent reproducibility and stability. The reported work shows that GO/Nafion is a promising candidate to be used in development of a modern highly sensitive humidity sensor.
Detection of a human melanoma‐associated antigen, p97, in histological sections of primary human melanomas

The unlabelled antibody technique of Sternberger was used to study the localization in histological sections of human melanoma‐associated antigen p97, which is defined by a monoclonal antibody. The antigen was detected in 8 of 10 primary skin melanomas, in 6 of 7 metastatic melanomas and in 2 of 2 compound nevi. It was localized at the cell surface, the cytoplasm and the nucleus always being negative. The antigen was not seen in cells from 3 basal cell carcinomas, I squamous cell carcinoma, I leiomyosarcoma, or in samples of normal skin (including keratinocytes, connective tissue consisting of collagenous and elastic fibers, fibroblasts, sebaceous glands, blood vessels, smooth muscles, or inflammatory cells such as granulocytes, lymphocytes and macrophages), kidney or lung. There was, however, staining of some cells in the secretory segment of eccrine sweat glands from 2 patients, possibly corresponding to myoepithelial cells. Antigen expression was somewhat variable between cells from different melanomas as well as between individual cells from the same melanoma. The possible diagnostic value of this procedure for identification and classification of melanomas is discussed.
Integrating professionalism into the curriculum: AMEE Guide No. 61

Professional values and behaviours are intrinsic to all medical practice, yet remain one of the most difficult subjects to integrate explicitly into a curriculum. Professionalism for the twenty-first century raises challenges not only to adapting the course to changing societal values but also for instilling skills of ongoing self-directed continuous development in trainees for future revalidation. This Guide is based on the contemporary available literature and focuses on instilling Professionalism positively into both undergraduate and postgraduate training deliberately avoiding the more negative aspects of Fitness to Practise. The literature on Professionalism is extensive. An evidence-based approach has been taken throughout. We have selected only some of the available publications to offer practical advice. Comprehensive reviews are available elsewhere (van Mook et al. 2009a–g). This Guide takes a structured stepwise approach and sequentially addresses: (i) agreeing an institutional definition, (ii) structuring the curriculum to integrate learning across all years, (iii) suggesting learning models, (iv) harnessing the impact of the formal, informal and hidden curricula and (v) assessing the learning. Finally, a few well-evaluated case studies for both teaching and assessment have been selected to illustrate our recommendations.
Anatomic Plantar Plate Repair Using the Weil Metatarsal Osteotomy Approach

The purpose of this study was to analyze the early results of a new technique for anatomic plantar plate repair and advancement using a Weil metatarsal osteotomy of the second metatarsal. The authors retrospectively reviewed medical records of 13 consecutive adult patients (15 feet) who underwent this procedure by a single surgeon. The authors recorded visual analog pain scale scores preoperatively and postoperatively and patient-reported clinical outcome measurement surveys during their final follow-up visit. At an average of 22.5 months (range, 13 to 33 months) follow-up, 11 of 13 patients (85%) reported improved function whereas 10 of 13 (77%) were either satisfied or very satisfied with the outcome. Postoperative scores on the American Orthopaedic Foot and Ankle Society Lesser Metatarsophalangeal— Interphalangeal Scale averaged 85.7 on a scale of 100 (SD = 13.1, 95% CI = 79.1-91.5). Patients reported an average preoperative visual analog pain scale of 7.3 (SD = 1.6, 95% CI = 6.4-8.1) versus an average of 1.7 (SD = 1.8, 95% CI = 0.7-2.7) postoperatively. This was a significant reduction in pain rating (P < .0001, t = 8.9, df = 27). Complications included painful hardware and metatarsalgia. There were no cases of dehiscence, malunion, nonunion, or recurrent metatarsophalangeal joint subluxation. This unique surgical technique addresses metatarsal overload and the instability of the second metatarsophalangeal joint while allowing for anatomic repair of the plantar plate pathology.
Control of nitrogenase recovery from oxygen inactivation by ammonia in the cyanobacterium Anabaena sp. strain CA (ATCC 33047)

The control of nitrogenase recovery from inactivation by oxygen was studied in Anabaena sp. strain CA (ATCC 33047). Nitrogenase activity (acetylene reduction) in cultures grown in 1% CO2 in air was inhibited by exposure to 1% CO2-99% O2 and allowed to recover in the presence of high oxygen tensions. Cultures exposed to hyperbaric levels of oxygen in the presence of 10 mM NH4NO3 were incapable of regaining nitrogenase activity, whereas control cultures returned to 65 to 80% of their original activity within about 3 h after exposure to high oxygen tension. In contrast to the regulation of heterocyst differentiation and nitrogenase synthesis, recovery from oxygen inactivation in this organism was shown to be under the control of NH4+ rather than NO3-.
Influence of Garlic Extract on Temporal Characteristics of Lipid Peroxidation Products and Antioxidants in Tumor-Bearing Rats

ABSTRACT Effects of garlic (Allium sativum. L.) extract on the temporal patterns of circulatory lipid peroxidation products and antioxidants during N. -nitrosodiethylamine (NDEA)-induced hepatic tumorigenesis were investigated in Wistar rats. Experimental animals were divided into control, NDEA-treated, NDEA + garlic-treated, and garlic-treated. The characteristics of circadian rhythms (acrophase, amplitude, and mesor) of lipid peroxidation products (thiobarbituric acid reactive substances) and antioxidants (reduced glutathione, glutathione peroxidase, superoxide dismutase, and catalase) were analyzed. Alterations in the temporal characteristics of all variables were observed in NDEA-treated rats when compared to other groups. The alterations in the characteristics of these variables in NDEA-treated and in other groups deserve further investigation for the prognosis and therapeutic efficacy of chronotherapy of cancer.
IL-27 Activates Human Monocytes via STAT1 and Suppresses IL-10 Production but the Inflammatory Functions of IL-27 Are Abrogated by TLRs and p381

IL-27 is a member of the IL-12 family of cytokines that activates the Jak-STAT signaling pathway in a context-dependent manner and has pleiotropic effects on acquired immunity. IL-27 has the capacity to promote early stages of Th1 generation, but recent evidence has suggested a predominant suppressive effect on Th1, Th2, and Th17 differentiation. Although modest suppressive effects of IL-27 on myeloid lineage cells have been observed, there is limited knowledge about the role of IL-27 in the regulation of innate immunity. In this study we report that although in resting murine macrophages IL-27 had minimal if any effects, in resting human monocytes IL-27 had profound proinflammatory functions. IL-27 activated a STAT1-dominant pattern of signaling in human monocytes with the consequent activation of STAT1-dependent inflammatory target genes. IL-27 primed monocytes for augmented responses to TLR stimulation in a STAT1-dependent manner, altered IL-10 signaling, and attenuated IL-10-induced gene expression. Strikingly, IL-27 strongly suppressed TLR-induced IL-10 production in human monocytes. However, the proinflammatory effects of IL-27 on human monocytes were rapidly abrogated by LPS via a p38-mediated mechanism that inhibited IL-27 signaling. Our findings identify a predominantly proinflammatory function for IL-27 in human monocytes and suggest a mechanism by which the activating effects of IL-27 on innate immunity are attenuated as an immune response proceeds and IL-27 transitions to predominantly suppressive effects on acquired immunity.
Investigations of Calsequestrin as a Target for Anthracyclines: Comparison of Functional Effects of Daunorubicin, Daunorubicinol, and Trifluoperazine

Anthracycline therapy is associated with a life-threatening but poorly understood cardiotoxicity. Effects of treatment are consistent with drug-induced disruption of cardiac sarcoplasmic reticulum (SR) calcium homeostasis, including inhibition of calcium release by anthracyclines. This effect, which depends on luminal SR calcium concentration, is hypothesized to involve interactions of anthracyclines with the calcium binding protein calsequestrin (CSQ). This study was designed to test the hypothesis that an interaction between CSQ and anthracyclines could be related to alterations in SR calcium release and cardiac function. The effects of the anthracycline, daunorubicin, and its metabolite daunorubicinol were compared with those of a known CSQ inhibitor, trifluoperazine (TFP). Protein fluorescence quenching studies demonstrated that TFP, daunorubicin, and daunorubicinol bind to CSQ with apparent binding affinities in the low micromolar range. The presence of calcium decreases the drug-dependent fluorescence quenching, probably because of calcium-induced CSQ conformational changes. TFP also inhibited SR calcium release. Although the TFP IC50 value is somewhat larger than for anthracyclines, the TFP effect is also dependent on luminal SR calcium concentration. In a muscle preparation, micromolar TFP decreased cardiac contractility in a manner that implicates the involvement of SR calcium and resembles the effects of anthracyclines. These data are consistent with a mechanism in which TFP or anthracyclines impair SR calcium release and cardiac function through a mechanism involving disruption of CSQ function. Such a mechanism may contribute to anthracycline cardiotoxicity.
Layer Recurrent Neural Networks

In this paper, we propose a Layer-RNN (L-RNN) module that is able to learn contextual information adaptively using within-layer recurrence. Our contributions are three-fold: (i) we propose a hybrid neural network architecture that interleaves traditional convolutional layers with L-RNN module for learning long- range dependencies at multiple levels; (ii) we show that a L-RNN module can be seamlessly inserted into any convolutional layer of a pre-trained CNN, and the entire network then fine-tuned, leading to a boost in performance; (iii) we report experiments on the CIFAR-10 classification task, showing that a network with interleaved convolutional layers and L-RNN modules, achieves comparable results (5.39% top1 error) using only 15 layers and fewer parameters to ResNet-164 (5.46%); and on the PASCAL VOC2012 semantic segmentation task, we show that the performance of a pre-trained FCN network can be boosted by 5% (mean IOU) by simply inserting Layer-RNNs.
Destructive ophthalmic surgical procedures in Onitsha, Nigeria.

OBJECTIVES to determine the incidence, trend and causes for surgical removal of the eyeball at the Guinness Eye Center Onitsha, Nigeria. PATIENTS AND METHODS Case files and theatre records of all patients who had eviscreration, enucleation or exenteration at the Guinness Eye Center Onitsha between 1995 and 2001 were reviewed. Information on age, sex, disease duration before hospital presentation, indication for surgery and the type of surgery were analysed. RESULTS 56 eyes of 56 patients were surgically removed. Patients including some with penetrating eye injuries presented late for treatment; 37.5% and 53.5% had used traditional eye medicines (TEM) and eye drops possibly containing steroids, respectively, prior to hospital consultation. The indications for surgery were severe ocular infections, especially panophthalmitis; severe penetrating eye injuries and orbito-ocular tumours. The annual incidence ranged from 1.9 - 4.2% with an average of 3.4% . The downward trend observed in the later part of the study was associated with reduced incidence of ocular gunshot injuries, which in turn coincided with a reduction in violent crime in Onitsha and its environs. CONCLUSIONS In spite of the observed downward trend in the rate of destructive eye surgery, the incidence of such procedures could be reduced further by timely intervention with modern microsurgical techniques; intraocular antibiotics and radiotherapy. The public should be educated on the harmful effects of TEM and abuse of eye drops. Those with eye problems should seek early hospital treatment.
Mini vs. Standard Implants for Mandibular Overdentures

A mandibular implant-retained overdenture is considered a first-choice treatment for edentulism. However, some aspects limit the use of standard implants—for example, the width of edentulous ridges, chronic diseases, fear, or costs. This randomized trial compared mandibular overdentures retained by 2 or 4 mini-implants with standard implants, considering oral health–related quality of life (OHRQoL), patient satisfaction, and complications such as lost implant. In sum, 120 edentulous men and women (mean age, 59.5 ± 8.5 y) randomly received 4 mini-implants, 2 mini-implants, or 2 standard implants. Participants provided data regarding OHRQoL and satisfaction until 12 mo. Clinical parameters, including implant survival rate, were also recorded. Both 2 and 4 mini-implants led to better OHRQoL, compared with 2 standard implants. Treatment with 4 mini-implants was more satisfying than 2 standard implants, with 2 mini-implants presenting intermediate results. Implant survival rate was 89%, 82%, and 99% for 4 mini-implants, 2 mini-implants, or 2 standard implants, respectively. Overdentures retained by 4 or 2 mini-implants can achieve OHRQoL and satisfaction at least comparable with that of 2 standard implants. However, the survival rate of mini implants is not as high as that of standard implants (ClinicalTrials.gov NCT01411683).
Stability and Performance of a Population Pharmacokinetic Model

This study aimed to determine the stability (in terms of covariate selection) of a population pharmacokinetic model and evaluate its performance in the absence of a test data set. Data from 88 full‐term infants, 11 of whom were human immunodeficiency virus (HIV)–seropositive, taking an antiinfective agent were analyzed using exploratory data analysis methods and the nonlinear mixed‐effects modeling (NONMEM) program to obtain the final population pharmacokinetic model. The stability of the population pharmacokinetic model was tested using the nonparametric bootstrap approach in four steps: 1) with the base pharmacokinetic model, 100 bootstrap replicates of the original data were generated by sampling with replacement; 2) ascertainment that each bootstrap data replicate was described by the basic structural model using the NONMEM objective function; 3) generalized additive modeling (GAM) applied to empiric Bayesian estimates for covariate selection at α = 0.05 and a frequency (f) cutoff value of 0.50; and 4) NONMEM population model building using covariates selected in the third step with α = 0.005. Performance of the population pharmacokinetic model was evaluated using 200 additional bootstrap replicates of the data by fitting the model obtained in step 4 to them. Parameters obtained were compared with those obtained in the model stability step, and improved prediction error, a measure of predictive accuracy as an index of internal validation, was computed. The reciprocal of serum creatinine (RSC; f = 0.73) and HIV (f = 0.70) were selected by GAM as predictors of clearance (Cl). The population pharmacokinetic model obtained without the determination of model stability included RSC as a predictor of Cl, but the final model from the model stability step included both HIV and RSC as predictors of Cl. Final population pharmacokinetic parameters were obtained with this model fitted to the original data; however, the 95% confidence interval on the HIV status regression coefficient included zero, indicating no significance. The mean parameter estimates obtained with the additional 200 bootstrap replicates of data were within 15% of those obtained with the final model at the regression stability step. Bootstrap resampling procedure is useful for evaluating the stability and performance of a population model by repeatedly fitting it to the bootstrap samples when there is no test data set.
Effects of the Breathe Right Nasal Strips on Nasal Ventilation

The Breathe Right nasal strips are more and more commonly used, mainly by athletes, who hope to enhance their physical performance in competition and training. The effect of the device in such situations is uncertain and perhaps somewhat controversial. To investigate the effects of the nasal strips on nasal ventilation, 20 Caucasian individuals were objectively assessed using anterior rhinomanometry and acoustic rhinometry. The results showed a significant increase in all subjects of transnasal airflow and in the average cross-sectional area of the nasal cavity that quantifies objectively the subjective impression of improved nasal breathing. In such patients where an improvement in nasal ventilation is desired, the use of the Breathe Right nasal strips seems to offer a beneficial treatment.
Postictal suppression correlates with therapeutic efficacy for depression in bilateral sine and pulse wave electroconvulsive therapy

Abstract Ictal electroencephalography (EEG) parameters in electroconvulsive therapy (ECT) for depression reportedly correlate with therapeutic response and stimulus dosage, particularly in right unilateral (RUL) ECT. The authors examined ictal EEG parameters as predictors of therapeutic effectiveness in bilateral (BL) sine and pulse wave ECT. A total of 30 consecutive depressed inpatients who had not responded to standard pharmacotherapy were treated using BL ECT given in either sine or pulse wave mode. Ictal EEG parameters (e.g. regularity, postictal suppression) were manually rated by three trained psychiatrists. Polyspike phase duration was significantly longer in sine wave ECT than in pulse wave ECT. Postictal suppression emerged as the only significant predictor of therapeutic outcome when baseline Hamilton Rating Scale for Depression and mode of stimulation were controlled for. Postictal suppression appears to offer a useful predictor of clinical outcome of depression in BL ECT. No EEG parameters were found to be differentially predictive between sine and pulse wave ECT.
PilB and PilT Are ATPases Acting Antagonistically in Type IV Pilus Function in Myxococcus xanthus

ABSTRACT Type IV pili (T4P) are dynamic surface structures that undergo cycles of extension and retraction. T4P dynamics center on the PilB and PilT proteins, which are members of the secretion ATPase superfamily of proteins. Here, we show that PilB and PilT of the T4P system in Myxococcus xanthus have ATPase activity in vitro. Using a structure-guided approach, we systematically mutagenized PilB and PilT to resolve whether both ATP binding and hydrolysis are important for PilB and PilT function in vivo. PilB as well as PilT ATPase activity was abolished in vitro by replacement of conserved residues in the Walker A and Walker B boxes that are involved in ATP binding and hydrolysis, respectively. PilB proteins containing mutant Walker A or Walker B boxes were nonfunctional in vivo and unable to support T4P extension. PilT proteins containing mutant Walker A or Walker B boxes were also nonfunctional in vivo and unable to support T4P retraction. These data provide genetic evidence that both ATP binding and hydrolysis by PilB are essential for T4P extension and that both ATP binding and hydrolysis by PilT are essential for T4P retraction. Thus, PilB and PilT are ATPases that act at distinct steps in the T4P extension/retraction cycle in vivo.