Miracle-dz/UniFAR-FTUs huggingface dataset:
Suppression of Fluorophenylalanine Resistance by Mutation to Streptomycin Resistance in Pseudomonas aeruginosa

Waltho, Judith A. (University of Melbourne, Victoria, Australia), and B. W. Holloway. Suppression of fluorophenylalanine resistance by mutation to streptomycin resistance in Pseudomonas aeruginosa. J. Bacteriol. 92:35–42. 1966. —Fluorophenylalanine-resistant mutants (fpa-r) of Pseudomonas aeruginosa have been isolated. By cotransduction analysis, the mutations were shown to have at least two chromosomal locations. One locus (fpaA) showed linkage to three other markers, str, try-3bi, and arg-3, and the order of these four linked markers was found to be try-3bi, arg-3, fpaA, str. The linkage relationships of the other fpa loci are not yet known. The phenotypic expression of resistance at the fpaA locus can be suppressed by mutation of the str locus from str-s to str-r, whereas that at an unlinked fpa locus cannot.
Modelling of the dispersed air flotation process applied to dairy wastewater treatment

The aim of this work was to develop a mathematical model for a continuously operating flotation tank to provide the scale-up and optimization of the separation system. The fluid dynamic of the tank was assumed to be a perfect mixture and the flotation kinetics to be a first-order reaction, as suggested by the batch operation. The experiments were carried out in a continuously operating 60 L tank, used in the treatment of a synthetic dairy waste at its isoelectric point. A mathematical model that describes the behavior of a continuously operating flotation tank used in the treatment of a synthetic dairy waste at its isoelectric point is not only proposed, but also validated with experimental data.
Approximating Fixed Points of Weakly Contracting Mappings

Abstract We consider the problem of approximating fixed points of contractive functions whose contraction factor is close to 1. In a previous paper (1993, K. Sikorski et al. , J. Complexity 9 , 181–200), we proved that for the absolute error criterion, the upper bound on the number of function evaluations to compute e -approximations is O( n 3 (ln(1/ e )+ln(1/(1− q ))+ln n )) in the worst case, where 0 q n is the dimension of the problem. This upper bound is achieved by the circumscribed ellipsoid (CE) algorithm combined with a dimensional deflation process. In this paper we present an inscribed ellipsoid (IE) algorithm that enjoys O( n (ln(1/ e )+ln(1/(1− q )))) bound. For q close to 1, the IE algorithm thus runs in many fewer iterations than the simple iteration method, that requires ⌈ln(1/ e )/ln(1/ q )⌉ function evaluations. Our analysis also implies that: (1) The dimensional deflation procedure in the CE algorithm is not necessary and that the resulting “plain” CE algorithm enjoys O( n 2 (log(1/ e )+log(1/(1− q )))) upper bound on the number of function evaluations. (2) The IE algorithm solves the problem in the residual sense, i.e., computes x such that ‖ f ( x )− x ‖⩽ δ , with O( n ln(1/ δ )) function evaluations for every q ⩽1.
Mystical Languages of Unsaying

This text examines a mode of mystical discourse, "apophasis", which literally means "speaking away. " Sometimes translated as "negative theology," apophatic discourse embraces the impossibility of naming something that is ineffable by continually turning back upon its own propositions and names. In this study of apophasis in Greek, Christian and Islamic texts, Michael Sells offers a sustained, critical account of how apophatic language works, the conventions, logic, and paradoxes it employs, and the dilemmas encountered in any attempt to analyze it. This book includes readings of the most rigorously apophatic texts of Plotinus, John the Scot Eriugena, Ibn Arabi, Marguerite Porete, and Meister Eckhart, with comparative reference to important apophatic writers in the Jewish tradition, such as Abraham Abulafia and Moses de Leon. Sells reveals essential common features in the writings of these authors, despite their wide-ranging differences in era, tradition and theology. By showing how apophasis works as a mode of discourse rather than as a negative theology, this work aims to open the subject up for re-evaluation. Sells demonstrates that the more radical claims of apophatic writers - claims that critics have often dismissed as hyperbolic or condemned as pantheistic or nihilistic - are vital to an adequate account of the mystical languages of unsaying. This work also has implications for the relationship of classical apophasis to contemporary languages of the unsayable. Sells challenges many widely circulated characterizations of apophasis among deconstructionists, as well as a number of common notions about medieval thought and gender relations in medieval mysticism.
Serotonergic pathway genes and subtypes of alcoholism: association studies

Disturbances of the serotonergic pathway have been implicated in many psychiatric disorders, including alcoholism, aggression, schizophrenia and depression. The personality dimension of harm avoidance is correlated positively with the activity of mesolimbic serotonergic neurons. The goal of this study was to determine the role of the genes in this pathway in the development of type II alcoholism. A sample of alcoholics and normal controls were screened with the variations in tryptophan hydroxylase (TPH), serotonin receptors (5‐HT2A and 5‐HT2C), serotonin transporter (5‐HTT), and monoamine oxidase A (MAO‐A) genes. The results of association studies for type II alcoholics were the most significant with 5‐HTT (P = 0.011) and MAO‐A (P = 0.029) genes. However, after correction for multiple comparisons, none of the results reached the significance level. These data indicate that the genes in the serotonergic pathway may be involved in the development of type II alcoholism but the gene effects are very small.
Relative accuracy of fine‐needle aspiration and frozen section in the diagnosis of lesions of the parotid gland

Both fine‐needle aspiration (FNA) and frozen section (FS), although useful in preoperative and intraoperative management, have their advantages and pitfalls when used in the diagnosis of salivary gland lesions. The accuracy of each of these modalities has been assessed separately in many studies; a direct comparison of these techniques on a large cohort has not been well studied. Herein, we determine the relative accuracies of both FNA and FS in the diagnosis of salivary gland lesions.
Physical constraints on the likelihood of life on exoplanets

Abstract One of the most fundamental questions in exoplanetology is to determine whether a given planet is habitable. We estimate the relative likelihood of a planet's propensity towards habitability by considering key physical characteristics such as the role of temperature on ecological and evolutionary processes, and atmospheric losses via hydrodynamic escape and stellar wind erosion. From our analysis, we demonstrate that Earth-sized exoplanets in the habitable zone around M-dwarfs seemingly display much lower prospects of being habitable relative to Earth, owing to the higher incident ultraviolet fluxes and closer distances to the host star. We illustrate our results by specifically computing the likelihood (of supporting life) for the recently discovered exoplanets, Proxima b and TRAPPIST-1e, which we find to be several orders of magnitude smaller than that of Earth.
Adverse Effects of Marijuana Use

Marijuana has consistently been reported as the most commonly used illicit substance in the United States each year. Currently, the legalization of marijuana is up for debate across the nation. While marijuana use is prevalent among the adolescent population, research has shown that there can be devastating effects on health and well-being. A review of the literature shows that marijuana use can have a negative impact on physical health, psychological well-being, and multiple psychosocial outcomes. Adolescents who used marijuana more frequently and began using marijuana at an earlier age experienced worse outcomes and long-lasting effects. Lay Summary: This article reviews recent literature regarding adverse effects of marijuana use. Negative effects of marijuana use relating to physical health, psychological well-being, and outcomes such as academic performance are discussed, especially in relation to the adolescent population.
Gender Violence Among Teenagers

This Spanish-based study found that some adolescents link attractiveness with violence. Previous research showed that a socialization process within teenagers' contexts promotes this association. The results suggest that this link is one of the possible causes of the high rates of gender violence among youth. Debates regarding this research already have had political repercussions. Although the 2004 Spanish Act Against Gender Violence—the first of its kind in Europe—acknowledged violence with romantic partners or ex-partners, the 2008 Catalan Act on the Right of Women to Eradicate Chauvinist Violence also recognizes gender violence in dating, and considers preventive socialization as a main measure. This study provides key knowledge to support this purpose.
The formation, structure, and electronic properties of Lansoprazol drug and cucurbit [7]urils complex (Theoretical Study)

The current study deals with host-guest complex formation between cucurbit [7] urils as host and lansoprazole as guesti using PM3 (semi empirical molecules orbital calculations) also DFT calculations. In this complex, the formation of hydrogen bonding may be occurred through portal oxygen atoms(O2) of cucurbit [7] urils and amine groups (NH 2 )of the drug. The energies of HOMO and LUMO orbital’s have been computed for the host guest complex and its components. The result of the stabilization energy explained a complex formation.
Ankle Joint Complex Mobility of Children 7 to 14 Years Old

The ranges of motions of the ankle have been studied only rarely in children. The authors examined the mobility of the ankle joint complex of 245 healthy children. The mean age was 10.2 years. In healthy children ages 7 to 14 years, the variation of the ankle joint complex range of motion was wide. The largest gender-related difference was recorded for passive plantarflexion, which was greater in girls. Other statistically significant gender differences do exist, but they are small and probably lack clinical meaning. Some of the children had remarkable left–right difference in the range of motions of the ankle joint complex. This means that the “healthy ankle” cannot necessarily be used in clinical practice as a reference when evaluating, for example, treatments of foot and ankle injuries in children.
Recognizing Top-Monotonic Preference Profiles in Polynomial Time

We provide the first polynomial-time algorithm for recognizing if a profile of (possibly weak) preference orders is top-monotonic. Top-monotonicity is a generalization of the notions of single-peakedness and single-crossingness, defined by Barbera and Moreno. Top-monotonic profiles always have weak Condorcet winners and satisfy a variant of the median voter theorem. Our algorithm proceeds by reducing the recognition problem to the SAT-2CNF problem.
Secondary metabolites from marine microorganisms: bacteria, protozoa, algae and fungi. Achievements and prospects.

18 Introduction Bacteria (Eubacteria) Actinobacteria Cyanobacteria 0 ther bacteria Archaebacteria Euglenoids (Euglenoidea, Euglenozoa, Protozoa) Dinoflagellates (Dinoflagellatea, Dinozoa, Protozoa) Ciliates (Ciliophora, Protozoa) Chrysophytes (Chrysophyceae, Phaeophyta, Chromista) Diatoms (Bacillariophyceae, Diatomae, Chromista) Eustigmatophytes (Eustigmatophyceae, Phaeophyta, Chromista) Raphidophytes (Raphidophyta, Chromista) Prymnesiophytes (Prymnesiophyta=Haptomonada, Chromista) Cryptophytes (Cryptophyceae, Cryptophyta, Chromista) Prasinophytes or grass-green scaly algae (Prasinophyta, Plantae) Green microalgae (Chlorophyta, Plantae) Red microalgae (Rhodophyta, Plantae) Fungi (Eumycota) True marine ascomycetes True marine deuteromycetes Terrestrial-genera deuteromycetes Products of proven or alleged microbial origin isolated from marine macroorganisms References
HETEROSEXUALSIGNALLING BY THE LIZARD ANOLIS CAROLINENSIS , WITH INTERSEXUAL COMPARISONSACROSS CONTEXTS

We quanti ed the structure and use of signals exchanged by males and females within the female-defencepolygyny of the lizard, Anolis carolinensis. During heterosexual interactions, both sexes performed three kinds of stereotypic headbob displays (A, B, and C) with equal precision. These three display types were essentially identical to A, B, and C display types previously documented for both sexes during consexual contests, and for males when displaying alone (non-directed context). Therefore, there is no courtship-specic headbob display in A. carolinensis. Although interacting males and females displayed at a similar mean frequency (»20 displays/h), signalling was sexually dimorphic in that: (1) males used predominately C displays (89%), whereas females used predominantly A and B displays (48% and 50%, respectively); (2) males extended their dewlaps with almost every display (98%), whereas females extended their dewlaps with few displays (<2%); (3) males sequenced 80% of displays in volleys of two or more displays, whereas females performed only 12% of displays in volleys; and (4) males concluded 22% of displays with shudderbobs (i.e. display modi er composed of shallow, quick, double bobs), whereas females never appended displays with shudderbobs. From  eld and laboratory data on A. carolinensis signal behaviour during other social contexts and the species’ female-defencemating system, we interpret heterosexual signalling from a perspective of intrasexual selection to discuss the: (1) absence
Beam finite-element model of a molecular motor for the simulation of active fibre networks

Molecular motors are proteins that excessively increase the efficiency of subcellular transport processes. They allow for cell division, nutrient transport and even macroscopic muscle movement. In order to understand the effect of motors in large biopolymer networks, e.g. the cytoskeleton, we require a suitable model of a molecular motor. In this contribution, we present such a model based on a geometrically exact beam finite-element formulation. We discuss the numerical model of a non-processive motor such as myosin II, which interacts with actin filaments. Based on experimental data and inspired by the theoretical understanding offered by the power-stroke model and the swinging-cross-bridge model, we parametrize our numerical model in order to achieve the effect that a physiological motor has on its cargo. To this end, we introduce the mechanical and mathematical foundations of the model, then discuss its calibration, prove its usefulness by conducting finite-element simulations of actin–myosin motility assays and assess the influence of motors on the rheology of semi-flexible biopolymer networks.
Prevalence of the Metabolic Syndrome in Latin America and its association with subclinical carotid atherosclerosis : the CARMELA cross sectional study

Background: Metabolic syndrome increases cardiovascular risk. Limited information on its prevalence in Latin America is available. The Cardiovascular Risk Factor Multiple Evaluation in Latin America (CARMELA) study included assessment of metabolic syndrome in 7 urban Latin American populations. Methods: CARMELA was a cross-sectional, population-based, observational study conducted in Barquisimeto, Venezuela; Bogota, Colombia; Buenos Aires, Argentina; Lima, Peru; Mexico City, Mexico; Quito, Ecuador; and Santiago, Chile. The prevalence of metabolic syndrome, defined according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III), and associated carotid atherosclerosis were investigated in 11,502 participants aged 25 to 64 years. Results: Across CARMELA cities, metabolic syndrome was most prevalent in Mexico City (27%) and Barquisimeto (26%), followed by Santiago (21%), Bogota (20%), Lima (18%), Buenos Aires (17%), and Quito (14%). In nondiabetic participants, prevalence was slightly lower but followed a comparable ranking. Overall, 59%, 59%, and 73% of women with high triglycerides, hypertension, or glucose abnormalities, respectively, and 64%, 48% and 71% of men with abdominal obesity, hypertension, or glucose abnormalities, respectively, had the full metabolic syndrome. Prevalence of metabolic syndrome increased with age, markedly so in women. Mean common carotid artery intima-media thickness (CCAIMT) and prevalence of carotid plaque increased steeply with Published: 26 September 2009 Cardiovascular Diabetology 2009, 8:52 doi:10.1186/1475-2840-8-52 Received: 3 August 2009 Accepted: 26 September 2009 This article is available from: http://www.cardiab. com/content/8/1/52 © 2009 Escobedo et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Shuganjieyu capsule increases neurotrophic factor expression in a rat model of depression

Shuganjieyu capsule has been approved for clinical treatment by the State Food and Drug Ad-ministration of China since 2008. In the clinic, Shuganjieyu capsule is often used to treat mild to moderate depression. In the rat model of depression established in this study, Shuganjieyu capsule was administered intragastrically daily before stress. Behavioral results confirmed that depressive symptoms lessened after treatment with high-dose (150 mg/kg) Shuganjieyu capsule. Immunohistochemistry results showed that high-dose Shuganjieyu capsule significantly increased phosphorylation levels of phosphorylation cyclic adenosine monophosphate response element binding protein and brain-derived neurotrophic factor expression in the medial prefrontal cortex and hippocampal CA3 area. Overall, our results suggest that in rats, Shuganjieyu capsule effec-tively reverses depressive-like behaviors by increasing expression levels of neurotrophic factors in the brain.
Identification of acute myeloid leukemia in dogs using flow cytometry with myeloperoxidase, MAC387, and a canine neutrophil-specific antibody.

BACKGROUND Flow cytometry may be used to determine immunophenotype or lineage of leukemic cells, but few antibodies are available that are specific for cells of monocytic and granulocytic lineage. OBJECTIVE The purpose of this study was to evaluate the flow cytometric staining patterns of 3 commercial monoclonal antibodies for monocytes and granulocytes in clinically healthy dogs and in dogs with acute myeloid leukemia (AML). METHODS Mouse antihuman macrophage antibody (MAC387), mouse anti-human myeloperoxidase (MPO), and a canine neutrophil-specific antibody (NSA) were evaluated using flow cytometry on blood from 6 clinically healthy control dogs, and on blood (n = 7) and/or bone marrow (n = 2) from 8 dogs with AML. A diagnosis of acute leukemia was confirmed by >30% blasts in bone marrow or >30% blasts in peripheral blood, together with bi- or pancytopenia, circulating CD34-positive blast cells, and clinical signs of disease. Leukemic samples also were evaluated using a wide panel of monoclonal antibodies. RESULTS MAC387 stained neutrophils and monocytes from control dogs, although the staining profiles for the 2 cell types differed. MPO and NSA resulted in strong positive staining of neutrophils; MPO also stained monocytes weakly. Lymphocytes did not stain with any of the antibodies. One case was classified as AML of granulocytic lineage (AML-M1), 6 cases were classified as acute monocytic leukemia (AML-M5), and 1 case was classified as acute myelomonocytic leukemia (AML-M4). Neoplastic myeloblasts in the dog with granulocytic AML were positive for MPO, NSA, MAC387, and CD4. All monoblasts from the dogs with AML-M5 were positive for CD14, 5 of 6 were positive for MAC387, and 2 were positive for MPO. NSA staining was negative in the 2 dogs with AML-M5 in which it was evaluated. In the dog with AML-M4 variable percentages of blast cells were positive for CD14, MPO, MAC387, CD4, and NSA. CONCLUSIONS Antigens identified by antibodies to MAC387, MPO, and NSA were expressed not just by normal mature neutrophils and monocytes, but also by neoplastic myeloblasts and monoblasts. These 3 antibodies may be useful as part of a wider panel for immunophenotyping AML in dogs.
The practice patterns of recently graduated internal medicine-pediatric hospitalists.

OBJECTIVES To identify the current practice patterns and professional activities of internal medicine-pediatrics (med-peds) hospitalists who have graduated in the past 5 years (June 2009-June 2013). METHODS The national Medicine-Pediatrics Program Directors Association (MPPDA) conducted a cross-sectional survey study of the 79 residency program directors who are members of the MPPDA regarding the practice patterns of recent graduates (from 2009-2013) currently practicing as hospitalists. The survey was distributed in the spring of 2014 on the MPPDA listserv. The survey inquired about time spent caring for hospitalized adults and children, medical school appointments, practice in freestanding children's hospitals, and completion of hospital medicine (HM) fellowships. RESULTS Forty-nine program directors (62%) completed the survey and provided data on 1042 graduates from 46 programs. Of those graduates, 26.4% (n=275) practice as hospitalists, and none had completed an HM fellowship. Approximately two-thirds (65%) of med-peds hospitalists provide care to hospitalized children and adults, with one-third providing care solely to hospitalized adults. Approximately one-half (53.5%) have an appointment with a medical school and roughly one-quarter (28%) practice in a freestanding children's hospital. CONCLUSIONS An increasing percentage of recent med-peds graduates are pursuing careers in HM, and two-thirds are providing care to hospitalized children. As consideration for an accredited pediatric HM fellowship continues, certifying and accrediting bodies should consider how this will impact the med-peds workforce and allow med-peds graduates flexibility in their training requirements that will permit them to acquire the necessary skills to care for hospitalized children and adults.
ETUDE THEORIQUE ET EXPERIMENTALE DE QUELQUES TYPES DE RESSAUTS HYDRAULIQUES DANS UN CANAL TRAPEZOÏDAL

Cette recherche a pour but d’etudier d’une maniere theorique et experimentale les differents types de ressauts hydrauliques evoluant dans un canal trapezoidal. L’objectif principal etant la determination des relations fonctionnelles pratiques permettant le dimensionnement des bassins de dissipation de charge hydraulique a l’aval des barrages, ainsi que le dimensionnement des canaux d’irrigation. En effet, il a ete etudie d’une maniere theorique et experimentale les caracteristiques de deux types de ressauts hydrauliques: le ressaut hydraulique evoluant dans un canal trapezoidal a pente variable et le ressaut hydraulique controle et force par marche positive. Cependant, pour mener a bien cette etude il a ete necessaire de concevoir et realiser a l’echelle du laboratoire un canal de forme trapezoidal.