Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of (3′,4′‐dichloro‐2‐(2‐imidazolin‐2‐yl‐thio)‐acetophenone hydrobromide) (DITA) on pulmonary and systemic arterial blood pressure: a comparison with diethylpropion

The use of the anorexigenic drug aminorex has been associated with a high incidence of progressive pulmonary hypertension (Gurtner, Gertsch & others, 1968), so too has chlorphentermine (Rau, 1969; Paeprer, 1970). As a result, anorexigenic drugs are suspected of causing pulmonary hypertension. We have compared the effects of the repeated acute administration of the anorexigenic agents DITA (3',4'-dichloro-2-(2-imidazolin-2-yl-thio)-acetophenone hydrobromide, Abdallah & White, 1974) and diethylpropion on the systemic and pulmonary arterial blood pressure of anaesthetized dogs. Mongrel dogs of either sex, 7 to 24 kg, were anaesthetized with pentobarbitone sodium (32.5 mg kg-', i.p.). Pulmonary arterial blood pressure was recorded by catheterization of either the femoral or jugular vein. The position of the tip of the catheter was verified by monitoring the changes in blood pressure as the catheter was advanced. The system was filled with a 0.9 % solution of sodium chloride (saline) which contained 10 units ml-' of heparin. Systemic arterial pressure was measured from a femoral artery cannulated with plastic tubing and attached to a pressure transducer. Mean pulmonary and systemic arterial blood pressures were recorded directly. Dogs were heparinized with 500 units kg-l (i.v.). A femoral vein was cannulated for the administration of drugs which were dissolved in saline shortly before use. (No change in blood pressure was observed on injection of vehicle alone). Each dog received one dose (2,4 or 8 mg kg-l) of the anorexigenic compound every 30min for 5 doses and 3 dogs were
Genetic Determinants of Clozapine-Induced Metabolic Side Effects

Objective: Atypical antipychotics are linked to a higher incidence of metabolic side effects, including weight gain, dyslipidemia, and diabetes. In this study, we examined the prevalence and potential genetic predictors of metabolic side effects in 60 adult patients on clozapine. Method: Genetic variants of relevance to clozapine metabolism, clearance, and response were assessed through targeted genotyping of cytochrome P450 enzymes CYP1A2 and CYP2C19, the efflux transporter ABCB1, the serotonin receptor (HTR2C), leptin (LEP), and leptin receptor (LEPR). Clozapine levels and other potential confounders, including concurrent medications, were also included in the analysis. Results: More than half of the patients were obese (51%), had metabolic syndrome (52.5%), and 30.5% were overweight. There was a high prevalence of antipsychotic polypharmacy (61.9%). With multivariable linear regression analysis, LEP –2548G>A, LEPR c.668A>G, and HTR2C c.551-3008 C>G were identified as genetic predictors of body mass index (BMI) after considering effects of clozapine dose, blood level, and concurrent medications (adjusted R2 = 0.305). Metabolic syndrome was found to be significantly associated with clozapine level and CYP2C19*2 and LEPR c.668 G alleles. Clozapine levels in patients with metabolic syndrome were significantly higher compared to those without metabolic syndrome (1886 ± 895 vs. 1283 ± 985 ng/mL, P < 0.01) and were associated with the CYP2C19*2 genotype. No association was found between the genetic variants studied and lipid or glucose levels. Conclusion: This study confirms a high prevalence of metabolic side effects with clozapine and suggests higher clozapine level and pharmacogenetic markers in CYP2C19, LEP, LEPR, and HTR2C receptors as important predictors of BMI and metabolic syndrome.
Differential Survival of Lyme Borreliosis Spirochetes in Ticks That Feed on Birds

ABSTRACT The abilities of the most common European genospecies of Borrelia burgdorferi sensu lato to survive blood meals taken by ticks feeding on birds were analyzed. A pattern of differential survival of the spirochetes in feeding ticks was observed. The result is consistent with the concept of selective transmission of Lyme borreliosis spirochetes.
The role of epilepsy surgery in southern Africa

Epilepsy surgery plays an important role in the management of patients with medically refractory temporal lobe epilepsy and lesional epilepsies. When performed early in the course of the illness, surgery can render many patients seizure‐free and greatly improve their quality of life. In southern Africa, as in many developing nations, thousands of patients could benefit from epilepsy surgery, but inequalities in healthcare provision mean that ready access to surgical facilities is largely restricted to those with private healthcare insurance. Over the past 5 years, more than 250 patients have had epilepsy surgery in Cape Town; the cause of epilepsy in six of these individuals was neurocysticercosis resulting from central nervous system infection by the larval stage of the pork tapeworm (Taenia solium), which is a common cause of epilepsy in the tropics. In all cases, surgery was successful, with patients becoming seizure‐free and reporting a much improved quality of life.
Cloning and Characterization of Two Human Isozymes of Mg2+-independent Phosphatidic Acid Phosphatase*

We obtained two human cDNA clones encoding phosphatidic acid phosphatase (PAP) isozymes named PAP-2a (M r = 32,158) and -2b (M r = 35, 119), both of which contained six putative transmembrane domains. Both enzymes were glycosylated and cleaved by N-glycanase and endo-β-galactosidase, thus suggesting their post-Golgi localization. PAP-2a and -2b shared 47% identical sequence and were judged to be the human counterparts of the previously sequenced mouse 35-kDa PAP(83% identity) and rat Dri42 protein (94% identity), respectively. Furthermore, the sequences of both PAPs were 34–39% identical to that of DrosophilaWunen protein. In view of the functions ascribed to Wunen and Dri42 in germ cell migration and epithelial differentiation, respectively, these findings unexpectedly suggest critical roles of PAP isoforms in cell growth and differentiation. Although the two PAPs hydrolyzed lysophosphatidate and ceramide-1-phosphate in addition to phosphatidate, the hydrolysis of sphingosine-1-phosphate was detected only for PAP-2b. PAP-2b was expressed almost ubiquitously in all human tissues examined, whereas the expression of PAP-2a was relatively variable, being extremely low in the placenta and thymus. In HeLa cells, the transcription of PAP-2a was not affected by different stimuli, whereas PAP-2b was induced (up to 3-fold) by epidermal growth factor. These findings indicate that despite structural similarities, the two PAP isozymes may play distinct functions through their different patterns of substrate utilization and transcriptional regulation.
Domestic Violence, Alcohol Consumption and Depression in Criminal Population

The objective of this research was to determine the differences in levels of domestic violence, alcohol and depression by type of crime committed on 259 men and 200 women inmates of the Centre for Social Rehabilitation in Mexico. To assess alcohol consumption indicators were adapted from the National Addiction Survey, the CES-D was used to measure depressive symptoms and in terms of domestic violence, we designed a 16-reactive scale evaluating: verbal aggression, physical aggression, humiliation and respect. The results showed significant differences not by gender but by type of crime committed, specifically on domestic violence, in which was found that women had higher scores than men. Furthermore, the analysis by type of crime committed found a higher number of subjects with severe consumption that health damages and homicides. Regarding depressive symptoms, the results showed that women had higher scores than men; however, these differences were not significant. In conclusion, data indicate relevant differences by gender in terms of domestic violence, depressive symptoms and substance use, but not so, on the type of crime by substance consumption, depression or family violence.
Remission of diabetes mellitus in cats cannot be predicted by the arginine stimulation test.

BACKGROUND Cats with diabetes mellitus frequently achieve clinical remission, suggesting residual β-cell function. Responsiveness of β-cells to arginine persists the longest during diabetes progression, making the intravenous arginine stimulation test (IVAST) a useful tool to assess residual insulin and glucagon secretion. HYPOTHESIS Diabetic cats with and without remission will have different arginine-induced insulin or glucagon response. ANIMALS Seventeen cats with diabetes, 7 healthy cats. METHODS Blood samples collected on admission and during subsequent IVAST. Glucose, insulin, and glucagon were measured. Response to IVAST was assessed by calculating the insulin and glucagon area under the curve (AUC) and the AUC glucagon-to-insulin ratio. Diabetic cats were treated with insulin and were followed for 18 weeks. Remission was defined as normoglycemia and disappearance of clinical signs of diabetes for ≥4 weeks, without requiring insulin. RESULTS Seven diabetic cats (41%) achieved remission. On admission, blood glucose concentration was significantly lower in cats with remission (median, 389 mg/dL; range, 342-536 mg/dL) than in those without remission (median, 506 mg/dL; range, 266-738 mg/dL). After IVAST, diabetic cats with remission had higher AUC glucagon-to-insulin ratios (median, 61; range, 34-852) than did cats without remission (median, 26; range, 20-498); glucose, insulin, and glucagon AUCs were not different. Diabetic cats had lower insulin AUC than did healthy cats but comparable glucagon AUC. CONCLUSIONS AND CLINICAL IMPORTANCE Diabetic cats with and without remission have similar arginine-stimulated insulin secretion on admission. Although cats with remission had lower blood glucose concentrations and higher AUC glucagon-to-insulin ratios, large overlap between groups prevents use of these parameters in clinical practice.
Intense vascular sprouting from rat femoral vein induced by prostaglandins E1 and E2

The formation of new capillaries from the rat femoral vein was specifically explored to assess whether venous vessels of this caliber may participate in the process of angiogenesis. Prostaglandins of the E series (PGE1 and PGE2) were administered into the soft connective tissue surrounding the rat femoral vessels as angiogenic inducers. In these conditions, between 2 and 7 days, a great number of new capillaries were observed in the media of the femoral vein, arising from the endothelial cells (EC) in the intima. The events of the capillary growth from the femoral vein included EC activation, local degradation of the basal membrane followed by migration and proliferation of EC, solid sprout formation with posterior canalization, development of a new basal membrane, and appearance of pericytes around the new capillary. Although numerous vascular buds were also observed arising from the small venules and capillaries in the periadventitial tissues, they were separated at first from those in the media of the femoral vein by the venous adventitia. Later, connections were observed between both newly formed microcirculations. The present study shows the capacity of PGE1 and PGE2 in the extravascular position of inducing capillary sprouting from veins. Furthermore, the observations provide greater evidence that vessels with characteristics similar to those of the rat femoral vein may contribute to angiogenesis, on occasion with an intense neovascularization. This fact may be of interest for the establishment of a functional circulation after angiogenesis by anastomoses of the new capillaries with those arising from pre‐existing vessels of greater caliber than the venules. © 1994 Wiley‐Liss, Inc.
Nominative-Genitive Conversion and ItsTransitivity Restriction in Child Japanese

Nominative-Genitive Conversion (NGC) in Japanese, which is also called Ga/No Conversion, is one of the most well-studied phenomena in Japanese syntax (see Harada 1971, 1976, Bedell 1972, Shibatani 1975, Nakai 1980, Saito 1983, 2004, Miyagawa 1993, to appear, Watanabe 1996, Hiraiwa 2001, 2005, and Ochi 2001, to appear, among many others). NGC is a Case alternation phenomenon in which the nominative Case marker ga on the subject DP is “converted” into the genitive Case marker no within a prenominal sentential modifier, as illustrated in (1).
A specific closed percutaneous technique for reduction of Jeffery type II lesion

Open reduction is commonly recommended in Jeffery type II fractures. Attempts to reduce these fractures percutaneously were reported as unsafe and unreliable. We revisited this technique and used a specific percutaneous reduction that turned out to be successful in two cases. Instead of lifting the radial head as described in leverage maneuver, we use a pushing-back procedure to reduce the fracture. The maneuver aims at suppressing the capitellum interposition between the head fragment and the metaphysis by reproducing the reversed trajectory of trauma. This reduction is made possible because of the posterior periosteal attachment of the radial head. A few weeks after the procedure, the two patients remained painless, recovered a complete range of motion in prono-supination and returned to sports. In these two cases, the procedure used led to a prompt recovery and provided a much better outcome than described with the classic open approach.
Diagnostic criteria for obstructive sleep apnea syndrome in children

The 1990 International Classification of Sleep Disorders Diagnostic and Coding Manual (hereinafter referred to as the ICSD) is the standard reference, world-wide, for clinical features and diagnostic criteria of sleep disorders including breathing disorders occurring during sleep. It was produced by an international committee, according to its introduction, “primarily for diagnostic and epidemiological purposes. ”’ It includes specific diagnostic criteria, which are intended for clinical and research use and are supposed to “allow for the unequivocal diagnosis of a particular disorder. ”’ The lCSD also contains a glossary of terms that are intended to be “widely used and standardized. ’” Unfortunately, these commendable goals are not yet realized with respect to childhood obstructive sleep apnea syndrome (OSAS). The purpose of this communication is to bring to light problems with the present criteria for OSAS (Table 1) as they relate to children. Clinicians and researchers should be aware of the limitations when attempting to apply these criteria in a pediatric setting.
Putting the Emotion Back: Exploring the Role of Emotion in Disengagement

Abstract This chapter explores the nature of disengagement and the role played by emotions while disentangling the overlapping theories and definitions of both engagement and disengagement. We carried out two related studies exploring engagement and disengagement in 10 large UK public and private sector organisations. Both studies used an interpretive approach involving 75 managers and employees. The chapter suggests that emotions play a mediating role in the process of disengagement and the emotional reaction involved provides a distinction to being ‘not engaged’. It highlights the confusion that different approaches bring to distinguishing engagement and disengagement from other job attitudes.
A self-adaptive variable impedance actuator based on intrinsic non-linear compliance and damping principles

Despite the growing focus on the design of compliant mechanisms for robotics actuators that manifest several advantages in terms of robustness and interaction-related characteristics, the incorporation of elasticity in the actuation drive renders under-damped vibration modes and reduces the bandwidth of the system. The addition of damping principles into compliant systems can address such impediments to accuracy and stability, and enhance the passivity characteristics of the controlled compliant actuator. However, passive damping mechanisms integrated into compliant systems to exhibit user-defined passive dissipation profiles have not been realized. This paper proposes a non-linear stiffness compliant module, and introduces a novel non-linear damper which complements the elastic element. The cam-follower mechanism was employed for rendering the user-defined non-linear behaviour. While the passive compliance of the module is replicated using a curved leaf spring, the passive damping is generated by rolling/sliding motion of a rigid cylinder on an elastomer. The design of the module is described, the theoretical modelling is presented, and experimental results validating the functionality of the proposed design in dissipating under-damped oscillations are demonstrated.
Role of breast tomosynthesis in diagnosis of breast cancer for Japanese women.

INTRODUCTION Mammography is the most basic modality in breast cancer imaging. However, the overlap of breast tissue depicted on conventional two-dimensional mammography (2DMMG) may create significant obstacles to detecting abnormalities, especially in dense or heterogeneously dense breasts. In three-dimensional digital breast tomosynthesis (3DBT), tomographic images of the breast are reconstructed from multiple projections acquired at different angles. It has reported that this technology allows the generation of 3D data, therefore overcoming the limitations of conventional 2DMMG for Western women. We assessed the detectability of lesions by conventional 2DMMG and 3DBT in diagnosis of breast cancer for Japanese women. METHODS The subjects were 195 breasts of 99 patients (median age of 48 years, range 34~82 years) that had been pathologically diagnosed with breast cancer from December 20, 2010 through March 31, 2011. Both conventional 2DMMG and 3DBT imaging were performed for all patients. Detectability of lesions was assessed based on differences in category class. RESULTS Of the affected breasts, 77 (75.5%) had lesions assigned to the same categories by 2DMMG and 3DBT. For 24 (23.5%) lesions, the category increased in 3DBT indicating improvement in diagnostic performance compared to 2DMMG. 3DBT improved diagnostic sensitivity for patients with mass, focal asymmetric density (FAD), and architectural distortion. However, 3DBT was not statistically superior in diagnosis of the presence or absence of calcification. CONCLUSIONS In this study, 3DBT was superior in diagnosing lesions in form of mass, FAD, and/or architectural distortion. 3DBT is a novel technique that may provide a breakthrough in solving the difficulties of diagnosis caused by parenchyma overlap for Japanese women.
Effect of month of birth on hip dysplasia in labrador retrievers and Gordon setters

Recent studies have proposed selective breeding policies for preventing or controlling hip dysplasia, based upon the relationships between the hip scores of the offspring and their parents. However, these studies have ignored the possible effects on an animal's hip score of its age when it was examined and the month in which it was born. This paper describes the results of statistical analyses of large data sets of Kennel Club-registered labrador retrievers and Gordon setters. Regression modelling showed that an animal's hip score depended significantly upon the hip score of its sire and dam, and upon its month of birth. Enlarging the model by including its age when examined made it possible to quantify the significant genetic parental effects and the effects of the animal's month of birth and its age when examined.
When self-help materials help: Examining the effects of self-discrepancy and modes of delivery of positive self-statements

Self-help materials inculcating individuals with positive self-statements are popular in recent years, although the effectiveness of such self-statements on improving individuals’ psychological well-being has not yet been confirmed. Using a control-group pre-test/post-test design, we examined how positive self-statements may or may not benefit individuals’ mood. Individual characteristics and modes of delivery were found to moderate mood changes resulting from positive self-statements. Specifically, we found that participants experienced negative mood change after reading positive self-statements, if they have low level of need satisfaction. However, we also found that participants experienced a mood boost after listening to positive self-statements, and this effect was unrelated to self-esteem or need satisfaction. These findings suggest that self-help materials with a focus on positive self-statements should be used with caution.
TALOS: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial to Test the Effects of Citalopram in Patients with Acute Stroke

Rationale Selective Serotonin Reuptake Inhibitors (SSRI) are effective in the treatment of post-stroke depression and may have potential neuroprotective and vascular effects. Data from registry studies have further indicated a protective effect against recurrent ischemic events, but also an increased risk of bleeding in patients with ischemic stroke. Therefore, prospective studies are needed to determine the effects of SSRI treatment after acute ischemic stroke. Aims and design TALOS is an investigator-initiated, national multicenter randomized- and placebo-controlled, double-blind trial testing citalopram in acute ischemic stroke. We hypothesize that citalopram treatment initiated in the acute phase after ischemic stroke will improve outcome assessed by the modified Rankin Score (mRS) and reduce the risk of death from vascular causes, transient ischemic attack (TIA)/stroke and myocardial infarction. Study outcomes There are two co-primary effect variables: (i) Functional status at six-months, measured by the modified Rankin Scale, and (ii) Vascular death, TIA/stroke and myocardial infarction. Secondary effect variables include: (i) Single primary outcomes; (ii) The Barthel Index; (iii) Mini Mental State Examination at six-months; (iv) Final infarct size (Magnetic Resonance Imaging). Discussion SSRI treatment is well tolerated and overall beneficial in the wake of stroke; it may also be neuroprotective and prevent new vascular events.
Helper-Dependent Adenovirus Vectors Elicit Intact Innate but Attenuated Adaptive Host Immune Responses In Vivo

ABSTRACT Helper-dependent adenovirus (HD-Ad) vectors with all adenoviral genes deleted mediate very long-term expression of therapeutic transgenes in a variety of animal models of disease. These vectors are associated with reduced toxicity and improved safety relative to traditional early region 1 deletion first-generation Ad (FG-Ad) vectors. Many studies have clearly demonstrated that FG-Ad vectors induce innate and adaptive immune responses in vivo; however, a comprehensive analysis of host immune responses to HD-Ad vectors has not yet been performed. In DBA/2 mice, intravenous injection of HD-Ad vectors encoding LacZ (HD-AdLacZ) or a murine secreted alkaline phosphatase (HD-AdSEAP) induced an early expression of inflammatory cytokine and chemokine genes in the liver, including interferon-inducible protein 10, macrophage inflammatory protein 2, and tumor necrosis factor alpha, and were expressed in a pattern similar to that induced by FG-Ad vectors encoding AdSEAP. Like AdSEAP, and consistent with the pattern of cellular gene expression, HD-AdLacZ and HD-AdSEAP induced the recruitment of CD11b-positive leukocytes to the transduced liver within hours of administration. AdSEAP also induced a second phase of liver inflammation, consisting of inflammatory gene expression and CD3-positive lymphocytic infiltrates 7 days posttransduction. In contrast, beyond 24 h no infiltrates or expression of inflammatory genes was detected in the livers of mice receiving HD-AdSEAP. Despite the lack of liver inflammation at 7 days, Ad-specific cytotoxic T lymphocytes could be detected in mice receiving HD-AdSEAP. This lack of liver inflammation was not due to reduced transduction since levels of transgene expression and the amounts of vector DNA in the liver were equivalent in mice receiving HD-AdSEAP and AdSEAP. These results demonstrate that HD-Ad vectors induce intact innate but attenuated adaptive immune responses in vivo.