Miracle-dz/UniFAR-FTUs huggingface dataset:
Azidothymidine steady-state pharmacokinetics in patients with AIDS and AIDS-related complex.

Azidothymidine (AZT, 3'-azido-3'-deoxythymidine, zidovudine) is a thymidine analogue that has in vitro activity against human immunodeficiency virus (HIV). AZT is a selective inhibitor and substrate of the reverse transcriptase of HIV [1, 2]. AZT is incorporated into the HIV DNA strand that is being synthesized. Because AZT lacks the 3'-hydroxy group required for DNA elongation, AZT is a chain terminator [2]. The pharmacokinetics of AZT were studied during the initial phase I study [3, 4]. The drug is rapidly eliminated from the body (clearance of 1,900 mL/min) by both renal excretion and metabolism of AZT to 5'-glucuronyl azidothymidine (GAZT). GAZT is the major metabolite of AZT and lacks antiviral activity. In a double-blind, randomized, placebo-controlled trial, AZT was shown to be of therapeutic benefit in patients with symptomatic HIV infections [5]. It prolongs survival and decreases the incidence of opportunistic infections in patients who have AIDS or AIDS-related complex with significant symptom progression. Unfortunately, neutropenia or anemia or both are seen in \40% of patients [6]. After termination of the controlled trial, all patients were allowed to continue to receive open-label AZT, 200 mg every 4 h. We studied the pharmacokinetics of AZT at steady-state in six of these patients.
Response of Polypoidal Choroidal Vasculopathy Subtypes in a Multicenter , Randomized Controlled Trial

Citation: Tan CS, Lim LW, Ngo WK, Lim TH; for the EVEREST Study Group. EVEREST report 5: clinical outcomes and treatment response of polypoidal choroidal vasculopathy subtypes in a multicenter, randomized controlled trial. Invest Ophthalmol Vis Sci. 2018;59:889–896. https:// doi.org/10.1167/iovs.17-22683 PURPOSE. The purpose of this study was to describe the characteristics of polypoidal choroidal vasculopathy (PCV) subtypes among patients from a multicenter randomized controlled trial and to determine the impact of PCV subtypes on clinical outcomes.
A Phase-Contrast MRI Study to Investigate the Interaction of the CSF Dynamic with the Intracranial CSF Distribution

PURPOSES: Cine PC-MRI has shown that CSF oscillations increase with age, while the ratio between the CSF Oscillation in the aqueduct and the spinal canal is constant. Our aim was to test whether the CSF hydrodynamic can bring complementary information to study pediatric population with an increase of the CSF volume. Material and Method: Forty three patients, newborns and children (mean age: 31 ± 32 months; 5 days - 111 months) with an intracranial CSF volume increase (ventricular or/and subarachnoid spaces) underwent a morphological MRI along with cine PC-MRI to quantify CSF oscillations. We defined a ratio of the ventricular area to that of the intracranial subarachnoid spaces (CSFratio). We also determined an index called CSFdynamic, which equals the CSF aqueduct stroke volume (SVAq) divided by the cervical stroke volume (SVC2C3) at the level C2C3 in the spine. RESULTS: Twenty-three patients presented only ventricular dilatation: CSFdynamic = 20 ± 25; CSFratio: 120 ± 151; with no significant correlation, (rs = 0.152, p = 0.48). Sixteen patients presented both ventricular and subarachnoid space dilations: CSFdynamic = 18 ± 17; CSFratio = 1.67 ± 0.81; with significant positive correlation (rs = 0.5911 p = 0.016). CONCLUSIONS: In pediatric population, the absence of correlation between the dynamic of the CSF and its volume shows that the CSF oscillation does not result only of the size of the ventricles and/or the subarachnoid spaces. The CSF oscillations bring complementary information concerning the active aspect of the CSF.
Use of nutritional supplements by Danish elite athletes and fitness customers

The nutritional supplement (NS) industry is one of the fastest growing in the world, and NS use in Denmark is among the highest in Europe. However, the exact use in elite athletes and fitness customers targeted for doping control is unknown. Information from 634 doping control forms obtained in 2014 was evaluated (elite athletes: n = 361; fitness customers: n = 273). The majority of female (92.6%) and male (85.0%) elite athletes and female (100.0%) and male (94.0%) fitness customers declared using one or more NS. The use of non‐ergogenic NS was more prevalent in women than in men and in younger (15–34 years) compared with older (35–49 years) subjects, but it was less prevalent in intermittent compared with endurance and power/strength sports. Additionally, fitness customers who tested positive for doping also reported using more NS than subjects testing negative, indicating an association between NS and doping abuse. The present results demonstrate a very high prevalence of NS usage in both elite athletes and fitness customers. This highlights the importance of a strong national regulation of NS to avoid contamination of NS with doping substances.
Probabilistic topic models for sentiment analysis on the Web

Sentiment analysis aims to use automated tools to detect subjective information such as opinions, attitudes, and feelings expressed in text, and has received a rapid growth of interest in natural language processing in recent years. Probabilistic topic models, on the other hand, are capable of discovering hidden thematic structure in large archives of documents, and have been an active research area in the field of information retrieval. The work in this thesis focuses on developing topic models for automatic sentiment analysis of web data, by combining the ideas from both research domains. One noticeable issue of most previous work in sentiment analysis is that the trained classifier is domain dependent, and the labelled corpora required for training could be difficult to acquire in real world applications. Another issue is that the dependencies between sentiment/subjectivity and topics are not taken into consideration. The main contribution of this thesis is therefore the introduction of three probabilistic topic models, which address the above concerns by modelling sentiment/subjectivity and topic simultaneously. The first model is called the joint sentiment-topic (JST) model based on latent Dirichlet allocation (LDA), which detects sentiment and topic simultaneously from text. Unlike supervised approaches to sentiment classification which often fail to produce satisfactory performance when applied to new domains, the weakly-supervised nature of JST makes it highly portable to other domains, where the only supervision information required is a domain-independent sentiment lexicon. Apart from document-level sentiment classification results, JST can also extract sentiment-bearing topics automatically, which is a distinct feature compared to the existing sentiment analysis approaches. The second model is a dynamic version of JST called the dynamic joint sentimenttopic (dJST) model. dJST respects the ordering of documents, and allows the analysis of topic and sentiment evolution of document archives that are collected over a long time span. By accounting for the historical dependencies of documents from the past epochs in the generative process, dJST gives a richer posterior topical structure than JST, and can better respond to the permutations of topic prominence. We also derive online inference procedures based on a stochastic EM algorithm for efficiently updating the model parameters.
Archaeological and Paleoethnobotanical Investigations in Salts Cave, Mammoth Cave National Park, Kentucky

Abstract Reconnaissance, surface collecting, and test excavation were carried on in Salts Cave in August, 1963, by a joint Illinois State Museum-Cave Research Foundation expedition in cooperation with the National Park Service. Various analyses and secondary investigations have continued since then. The main upper passages of the cave were extensively visited during the last millennium B.C. by a prehistoric people who are probably to be assigned to the Early Woodland culture grouping. They were exploiting the mineral resources of the cave, primarily sulfate crystalline deposits, at least one of which is cathartic. Some individuals penetrated nearly two miles into the cave, using cane torches. Quantities of prehistoric, dried human feces are available and are yielding important dietary information. The people were apparently cultivating some plant species, including sunflower (Heliarn thus annus) and two members of the classic tropical horticultural complex, squash and gourd (Cucurbita pepo and Lagenarid siceraria). There is as yet no evidence that they grew or used maize (Zea mays).
An Efficient Multi-Message Multi-Receiver Signcryption Scheme with Forward Secrecy on Elliptic Curves

Secure multicast communication has application in growing number of applications. Forward secrecy is of prime importance and insures message con dentiality even long-term private key compromised. We present an e¢ cient construction of multi message multi receiver signcryption with forward secrecy on elliptic curves. It provides con dentiality, integrity, authenticity, non-repudiation, public veri ability, unforgeability and forward secrecy of multi message multicast. It is e¢ cient in computation cost and communication overhead and suitable for resource constrained IP-based secure multi message multicast systems.
Effect of hepatitis C infection and renal transplantation on survival in end-stage renal disease 1

Effect of hepatitis C infection and renal transplantation on survival in end-stage renal disease. Hepatitis C virus (HCV) infection is common among patients with end-stage renal disease (ESRD). However, the effect of HCV infection on survival among ESRD patients, and the impact of renal transplantation on the course of HCV infection has not been adequately defined. Sera from patients on the renal transplant waiting list at the New England Organ Bank between November 1986 and June 1990 were tested for anti-HCV using a third generation ELISA. All anti-HCV positive patients and a 1:1 ratio of randomly selected anti-HCV negative patients comprised the study sample. Duration of follow-up was calculated from the date of the first available serum specimen until death, loss to follow-up or December 31, 1995, whichever occurred earlier. Multivariate analysis of risk factors for mortality was performed using a Cox proportional hazards model which included anti-HCV as a time-independent (baseline) variable, transplantation as a time-dependent (follow-up) variable, and independently significant baseline covariates. Anti-HCV was detected in 287 (19%) of 1544 patients in whom sera were available, and 286 anti-HCV negative patients served as controls. Complete information was available in 496 (87%) of these 573 patients. Median follow-up was 73 months (range 1 to 110 months), during which time 302 (61%) patients underwent renal transplantation and 154 (31%) patients died. For antiHCV positive patients compared to anti-HCV negative patients, the relative risk of death (and 95% confidence intervals) from all causes was 1.41 (1.01 to 1.97) and due to liver disease or infection was 2.39 (1.28 to 4.48). For patients who underwent transplantation compared to those who remained on dialysis, the relative risk of death from all causes between 0 to 3 months, 3 to 6 months, seven months to four years, and after four years was 4.75 (2.76 to 8.17), 1.76 (0.75 to 4.13), 0.31 (0.18 to 0.54) and 0.84 (0.51 to 1.37), respectively. There was no interaction between the effect of anti-HCV status at baseline and subsequent transplantation (P 5 0.93), meaning that the association between treatment modality and survival was similar among anti-HCV positive and negative patients, at all intervals after transplantation. We conclude that HCV infection at the time of referral for transplantation is associated with an increased risk of death, irrespective of whether patients remain on dialysis or undergo transplantation. Transplantation has a beneficial rather than adverse effect on long-term survival in anti-HCV positive patients. Hence, antiHCV positive status alone is not a contraindication for renal transplantation.
Japanese Lung Cancer Registry Study of 11,663 Surgical Cases in 2004: Demographic and Prognosis Changes Over Decade

Background: The Japan Lung Cancer Society, the Japanese Association for Chest Surgery, and the Japanese Respiratory Society jointly established the Japanese Joint Committee for Lung Cancer Registration, which has regularly conducted lung cancer registries for surgical cases in 5-year periods. We analyzed data obtained in these registries to reveal the most recent surgical outcomes and trends related to lung cancer surgery in Japan. Methods: Using data from the registry in 2010 for cases of surgery performed in 2004, demographics, surgical results, and stage-specific prognoses were analyzed. In addition, trends for those parameters over 10 years were assessed. Results: The 5-year survival rate for all cases (n = 11,663, 7369 males, mean age 66.7 years) was 69.6%. The 5-year survival rates by c-stage and p-stage were as follow: IA, 82.0% (n = 6295) and 86.8% (n = 4978); IB, 66.8% (n = 2339) and 73.9% (n = 2552); IIA, 54.5% (n = 819) and 61.6% (n = 941); IIB, 46.4% (n = 648) and 49.8% (n = 848); IIIA, 42.8% (n = 1216) and 40.9% (n = 1804); IIIB, 40.3% (n = 90) and 27.8% (n = 106); and IV, 31.4% (n = 256) and 27.9% (n = 434), respectively. The percentages of female patients, cases with adenocarcinoma, stage I or II disease, and tumors sized less than 2 cm were increased, while those of operative and hospital deaths were decreased. Furthermore, the prognoses of all cases and cases in each stage improved over the decade. Conclusion: In Japanese cases of lung cancer surgery, demographics, surgical results, and stage-specific prognoses changed over the 10-year study period, while the 5-year survival rate for surgical cases improved to 69.6% in 2004.
Understanding Animate Agents

How people understand the actions of animate agents has been vigorously debated. This debate has centered on two hypotheses focused on anatomically distinct neural substrates: The mirror-system hypothesis proposes that the understanding of others is achieved via action simulation, and the social-network hypothesis proposes that such understanding is achieved via the integration of critical biological properties (e.g., faces, affect). In this study, we assessed the areas of the brain that were engaged when people interpreted and imagined moving shapes as animate or inanimate. Although observing and imagining the moving shapes engaged the mirror system, only activation of the social network was modulated by animacy.
Effect of soluble receptors to interleukin-1 and tumor necrosis factor alpha on experimentally induced root resorption in rats.

OBJECTIVE In this study, the role of the inflammatory cytokines interleukin-1 (IL-1) and tumor necrosis factor alpha (TNFalpha) in the course of mechanically induced root resorption was investigated. METHODS Mechanical induction of root resorption was performed on the upper left first molars in 18 male Wistar rats according to the method of Nakane and Kameyama. Starting on day minus 1, six animals received daily intraperitoneal injections of 2 ml of 1 micro g/ml soluble receptors to IL-1 (sIL-1RII) and another six animals were administered the same dose of soluble receptors to TNFalpha (sTNFalpha-RI). Six animals served as a control. On d 7 the left maxillae were prepared for histological and morphometric analysis of the extent of the root resorption that had developed. RESULTS The qualitative and quantitative results demonstrated that in both receptor groups the amount of root resorption was significantly reduced. Especially following systemic application of sTNFalpha-RI, root resorption was nearly completely prevented. CONCLUSIONS Our results indicate that IL-1 and more particularly TNFalpha are important for the induction and the further process of mechanically induced root resorption in the rat.
Gender Bias in Theiler’s Virus-Induced Demyelinating Disease Correlates with the Level of Antiviral Immune Responses1

Multiple sclerosis is an immune-mediated disease of the CNS and shows a sex-biased distribution in which 60–75% of all cases are female. A mouse model of multiple sclerosis, Theiler’s murine encephalomyelitis virus (TMEV)-induced demyelinating disease, also displays a gender bias. However, in the C57L/J strain of mice, males are susceptible to disease whereas females are completely resistant. In this study we determined the gender differences in the TMEV-specific immune response, which may be responsible for the gender bias in clinical disease. Our data clearly demonstrate that female C57L/J mice induce significantly higher levels of TMEV-specific neutralizing Ab as well as a stronger peripheral T cell response throughout the course of viral infection. In contrast, male mice have a higher level of TMEV-specific CD4+ and CD8+ T cell infiltration into the CNS as well as viral persistence. These results suggest that a higher level of the initial antiviral immune response in female mice may be able to effectively clear virus from the periphery and CNS and therefore prevent further disease manifestations. Male mice in contrast do not mount as effective an immune response, thereby allowing for eventual viral persistence in the CNS and continuous T cell expansion leading to clinical symptoms.
Delayed plasticity of inhibitory neurons in developing visual cortex

During postnatal development, altered sensory experience triggers the rapid reorganization of neuronal responses and connections in sensory neocortex. This experience-dependent plasticity is disrupted by reductions of intracortical inhibition. Little is known about how the responses of inhibitory cells themselves change during plasticity. We investigated the time course of inhibitory cell plasticity in mouse primary visual cortex by using functional two-photon microscopy with single-cell resolution and genetic identification of cell type. Initially, local inhibitory and excitatory cells had similar binocular visual response properties, both favoring the contralateral eye. After 2 days of monocular visual deprivation, excitatory cell responses shifted to favor the open eye, whereas inhibitory cells continued to respond more strongly to the deprived eye. By 4 days of deprivation, inhibitory cell responses shifted to match the faster changes in their excitatory counterparts. These findings reveal a dramatic delay in inhibitory cell plasticity. A minimal linear model reveals that the delay in inhibitory cell plasticity potently accelerates Hebbian plasticity in neighboring excitatory neurons. These findings offer a network-level explanation as to how inhibition regulates the experience-dependent plasticity of neocortex.
Hyperglycaemic effects of Hartmann's solution during surgery in patients with maturity onset diabetes.

The metabolic effect of infusing 1.0-1.5 litre of Hartmann's solution to normal subjects and those with maturity onset diabetes has been studied during surgery. It was found that the use of Hartmann's solution after operation was associated with a 7.5 mmol litre-u increase in plasm glucose concentration compared with an increase of 2.1 mmol litre-1 in diabetic patients who received no i.v. fluids. In non-diabetic subjects who received Hartmann's solution the increase was 2.5 mmol litre-1. It is suggested that Hartmann's solution may be metabolically disadvantageous in diabetic patients.
Adolescent and Young Adult (AYA) Oncology in the United States: A Specialty in Its Late Adolescence

Over the last 30 years, it has become apparent that oncology patients ages 15 to 39 have not reaped the same rewards of improved survival that we have seen in younger and older patients. As a result, in 2006 the Adolescent and Young Adult (AYA) Oncology Progress Review Group convened and examined the factors that impact the care of the 70,000 new cases per year (approximately 7% of all new cases) in the United States and published their findings. The reasons for inferior survival gains are of course multiple and include the settings in which patients are cared for, clinical trial enrollment, insurance coverage, varied treatment of sarcomas, varied treatment of acute lymphoblastic leukemia, the psychosocial impact of cancer and cancer survivorship. A new area of a yet-to-be completely defined subspecialty was born out of this meeting: AYA oncology. As a medical community we realized that these patients do not fit neatly into the pediatric nor adult world and, therefore, require a unique approach which many individuals, oncology centers, advocacy groups, and cooperative trial groups have started to address. This group of dedicated providers and advocates has made strides but there is still much work to be done on the local, national, and international level to make up for shortcomings in the medical system and improve outcomes. We review key components of AYA cancer care in 2015 that all providers should be aware of, how far we have come, where this movement is headed, and the obstacles that continue to stand in the way of better cure rates and quality of life after cure for this unique group of patients. Like an adolescent maturing into adulthood, this movement has learned from the past and is focused on moving into the future to achieve its goals.
Practices and opinions of pediatric and general dentists in Connecticut regarding the age 1 dental visit and dental care for children younger than 3 years old.

PURPOSE This study aimed to determine the percentage of general and pediatric dentists in Connecticut that were aware of, and practice, the current AAPD guidelines for the age one dental visit and to determine the services they provide to 0-2-yr-old patients. METHODS A survey was mailed to Connecticut general and pediatric dentists seeking information on practice type, years in practice, training, ages of children seen, procedures performed and opinions regarding the age one dental visit. RESULTS The response rate was 42% for general dentists and 84% for pediatric dentists, giving a sample of 113 and 60 dentists, respectively. All responding pediatric dentists reported seeing 0-2-yr-olds as compared to 42% of general dentists. Although not statistically significant, general dentists who were female or in practice less than 10 years were more likely to see 0-2-yr-olds. The majority of pediatric dentists reported performing all procedures surveyed, however, only just over half of general dentists provided topical fluoride or restorative care. Among pediatric dentists, 98% were aware of the AAPD guidelines and 92% agreed with them compared to 41% and 45% of general dentists respectively. CONCLUSIONS Nearly all Connecticut pediatric dentists are caring for 0-2-yr-olds compared to 42% of Connecticut general dentists.