Miracle-dz/UniFAR-FTUs huggingface dataset:
Dynamic Linkages Between Macroeconomic Factors and Islamic Stock Indices in a Non-Islamic Country India

The interaction between macroeconomic variables and share returns has been a debatable topic since decades. Much of the earlier studies have talked about significant relationships between stock market and macroeconomic indicators. In recent years Islamic finance has shown persistent growth worldwide. India has approximately 177 million Muslims, accounting for 12% of India's total population. Islamic finance differs from conventional investing in different ways like prohibition of gambling, pork, alcohol, entertainment, tobacco, profiting from interest rates etc. This paper aims to explore the long run and short run relationships of macroeconomic indicators and stock returns in the Indian context. The study is unique as it employs Shariah compliant indices to check on the stock market in India, a non - Islamic country. Data spans the period from January 2006 to July 2015. Monthly data is used and the selected macroeconomic variables are inflation rate (wholesale price index), interest rate (365 day government of India T-bill rate), money supply (M3) and exchange rate (US Dollar/Indian Rupee). 'Dow Jones Islamic Market India Total Return Index' is considered to track for the Shariah compliant stock index in Indian equity market. The study employs Johansen's co-integration and VECM to check for long run and short run equilibrium relationships. We check for long run equilibrium relationships through co-integration analysis. Johansen's test is a preferable multivariate cointegration test as it accounts for more than one cointegrating relationships. Granger causality is applied to check for the direction of causality. Variance decomposition in VAR system dynamics is also analyzed. Study reports the presence of a long run equilibrium relation between macroeconomic indicators and Dow Jones Islamic India market index. We are getting a positive and statistically significant relationship between WPI and stock returns as well as money supply and stock returns. Interest rate is showing negative and statistically significant relation with stock returns. Further uni-directional causality is observed from money supply and exchange rate to Dow Jones Islamic India market index. We can say that exchange rate as well as money supply granger causes Dow Jones Islamic India Market Index. Variance decomposition of exchange rate shows that 21.66% of variance in exchange rate is explained by Dow Jones index. Variance decomposition of Dow Jones index shows that money supply M3 explains 16.01% of variation in Dow Jones index. India's Islamic capital markets are showing signs of market inefficiency because of long run equilibrium relationships. This paper caters to the needs of Islamic investors and also to the policy makers as it provides a broad understanding of dynamic relationships between Shariah compliant stock returns and macroeconomic factors in India.
Relationship between Brain Blood Flow and Carotid Arterial Flow in the Sheep Fetus

ABSTRACT: The present study investigates whether changes in total brain blood flow can be reliably estimated by changes in carotid arterial blood flow in fetal and perinatal lambs. We therefore compared carotid arterial blood flow, measured with implanted transit-time ultrasound transducers, with brain blood flow, measured by radioactive microspheres in fetal lambs during normal oxygenation and during pulmonary ventilation with oxygen, with Po: ranging from levels normal for the healthy fetus to levels normally seen postnatally. Cerebral perfusion pressure was modified over a wide range to alter brain blood flow: it was decreased by balloon occlusion of the brachiocephalic trunk and increased by a balloon occluder around the aortic isthmus. Carotid arterial blood flow and brain blood flow were closely related (r = 0.97, p < 0.0001). The relationship was not altered at different levels of oxygenation. However, measurements during higher cerebral perfusion pressures, obtained during aortic isthmus occlusion, had a negative influence on the agreement between carotid arterial blood flow and brain blood flow. When excluding values obtained by aortic isthmus occlusion, changes of 20% or more in brain blood flow could be predicted with carotid arterial blood flow within a confidence limit of 95%. Blood flow measurements in the carotid artery may be useful to estimate changes in brain perfusion.
Relationship of anthropometric measures with bone mineral density in postmenopausal non-osteoporotic, osteopenic and osteoporotic women.

Background and objectives Body mass index (BMI) has been shown to be a more important predictor of bone mineral density (BMD). The objective of this study was to investigate the relationship of anthropometric measures including body mass index with bone mineral density in postmenopausal non-osteoporotic, osteopenic and osteoporotic women. METHODS In this cross sectional study postmenopausal females between 50-70 years of age were recruited and divided into three groups: non-osteoporotic (n=52), osteopenic (n=69) and osteoporotic females (n=47). Anthropometric measures and bone mineral density were assessed. ANOVA was applied to compare groups while Post hoc Tuckey's test was used for multiple comparisons between the groups. Spearman's rho correlation was used to establish correlations. RESULTS Body mass index (p = 0.034) and hip circumference (p = 0.013) were significantly higher in osteopenic as compared to osteoporotic females and waist to hip ratio was significantly higher (p = 0.005) in osteoporotic as compared to non-osteoporotic females. Significant positive correlation of body mass index was found with T-score (p = 0.022) and ultrasound bone profile index (p< 0.001) in postmenopausal females. CONCLUSIONS High body mass index is associated with high bone mineral density and reduced fracture risk in postmenopausal females. Increasing age and high waist to hip ratio can also lead to reduced bone mineral density in postmenopausal females.
Adipose-derived mesenchymal stem cells alleviate experimental colitis by inhibiting inflammatory and autoimmune responses.

BACKGROUND & AIMS Crohn's disease is a chronic disease characterized by severe T-helper (Th)1 cell-driven inflammation of the colon partially caused by a loss of immune tolerance against mucosal antigens. Mesenchymal stem cells were recently described to suppress effector T-cell responses and have therapeutic effects in some immune disorders. Here, we investigated the potential therapeutic effects of human adipose-derived mesenchymal stem cells (hASCs) in a model of inflammatory bowel disease. METHODS Mice with trinitrobenzene sulfonic acid-induced colitis were treated with hASCs after onset of disease and clinical scores were evaluated. Inflammatory response was determined by measuring the levels of different inflammatory mediators in colon and serum. Th1-mediated effector responses were evaluated by determining the proliferation and cytokine profile of activated mesenteric lymph node cells. The number of regulatory T cells and the suppressive capacity on Th1 cell responses was determined. RESULTS Systemic infusion of hASCs or murine ASCs ameliorated the clinical and histopathologic severity of colitis, abrogating body weight loss, diarrhea, and inflammation and increasing survival (P < .001). This therapeutic effect was mediated by down-regulating both Th1-driven autoimmune and inflammatory responses. ASCs decreased a wide panel of inflammatory cytokines and chemokines and increased interleukin-10 levels (P < .001), directly acting on activated macrophages. hASCs also impaired Th1 cell expansion and induced/activated CD4(+)CD25(+)FoxP3(+) regulatory T cells with suppressive capacity on Th1 effector responses in vitro and in vivo (P < .001). CONCLUSIONS hASCs emerge as key regulators of immune tolerance and as attractive candidates for a cell-based therapy for Crohn's disease.
Childhood Sexual Abuse in Adolescents Adjudicated for Sexual Offenses: Mental Health Consequences and Sexual Offending Behaviors

Most studies on the mental health consequences of childhood sexual abuse (CSA) focus predominantly on CSA survivors who do not commit sexual offenses. The current study examined the effects of CSA on 498 male adolescents adjudicated for sexual offenses who represent the small portion of CSA survivors who engage in sexual offenses. The prevalence of internalizing symptoms, parental attachment difficulties, specific sexual offending behaviors, and risk for sexually offending were compared among participants with and without a history of CSA. Results indicated that participants with a history of CSA were more likely to be diagnosed with major depression and posttraumatic stress disorder than those who did not report a history of CSA. A history of CSA was also positively correlated with risk for sexually offending and with specific offense patterns and consensual sexual behaviors. No significant differences emerged on parental attachment difficulties. These results highlight that adolescents adjudicated for sexual offenses with a history of CSA present with differences in sexual and psychological functioning as well as markedly different offending patterns when compared with those without a CSA history. Clinical implications and future directions are discussed.
Multifunctional Mitochondrial Epac1 Controls Myocardial Cell Death

Rationale: Although the second messenger cyclic AMP (cAMP) is physiologically beneficial in the heart, it largely contributes to cardiac disease progression when dysregulated. Current evidence suggests that cAMP is produced within mitochondria. However, mitochondrial cAMP signaling and its involvement in cardiac pathophysiology are far from being understood. Objective: To investigate the role of MitEpac1 (mitochondrial exchange protein directly activated by cAMP 1) in ischemia/reperfusion injury. Methods and Results: We show that Epac1 (exchange protein directly activated by cAMP 1) genetic ablation (Epac1−/−) protects against experimental myocardial ischemia/reperfusion injury with reduced infarct size and cardiomyocyte apoptosis. As observed in vivo, Epac1 inhibition prevents hypoxia/reoxygenation–induced adult cardiomyocyte apoptosis. Interestingly, a deleted form of Epac1 in its mitochondrial-targeting sequence protects against hypoxia/reoxygenation–induced cell death. Mechanistically, Epac1 favors Ca2+ exchange between the endoplasmic reticulum and the mitochondrion, by increasing interaction with a macromolecular complex composed of the VDAC1 (voltage-dependent anion channel 1), the GRP75 (chaperone glucose-regulated protein 75), and the IP3R1 (inositol-1,4,5-triphosphate receptor 1), leading to mitochondrial Ca2+ overload and opening of the mitochondrial permeability transition pore. In addition, our findings demonstrate that MitEpac1 inhibits isocitrate dehydrogenase 2 via the mitochondrial recruitment of CaMKII (Ca2+/calmodulin-dependent protein kinase II), which decreases nicotinamide adenine dinucleotide phosphate hydrogen synthesis, thereby, reducing the antioxidant capabilities of the cardiomyocyte. Conclusions: Our results reveal the existence, within mitochondria, of different cAMP–Epac1 microdomains that control myocardial cell death. In addition, our findings suggest Epac1 as a promising target for the treatment of ischemia-induced myocardial damage.
Heparin‐induced thrombocytopenia: a prospective study on the incidence, platelet‐activating capacity and clinical significance of antiplatelet factor 4/heparin antibodies of the IgG, IgM, and IgA classes

Summary. Introduction: Platelet‐activating antiplatelet factor 4/heparin (anti‐PF4/heparin) antibodies are the major cause of heparin‐induced thrombocytopenia (HIT). However, the relative utility of functional (platelet activation) vs. antigen [enzyme‐immunoassay (EIA)] assays, and the significance of assay discrepancies remain unresolved.Methods: Consecutive patient sera (n = 1650) referred for diagnostic HIT testing were screened prospectively by both the heparin‐induced platelet activation (HIPA) test and anti‐PF4/heparin EIA – including individual classes (IgG, IgA, IgM) – with clinical correlations studied. Platelet microparticle and annexin‐V‐binding properties of the sera were also investigated.Results: Only 205 (12.4%) sera tested positive in either the HIPA and/or EIA: 95 (46.3%) were positive in both, 109 (53.1%) were only EIA‐positive, and, notably, only one serum was HIPA‐positive/EIA‐negative. Of 185 EIA‐positive sera, only 17.6% had detectable IgM and/or IgA without detectable IgG. Among sera positive for EIA IgG, optical density values were higher when the sera were HIPA‐positive (1.117 vs. 0.768; P < 0.0001), with widely overlapping values. Two HIPA‐positive but EIA‐IgG‐negative sera became HIPA‐negative following IgG depletion, suggesting platelet‐activating antibodies against non‐PF4‐dependent antigens. Clinical correlations showed that HIPA‐negative/EIA‐positive patients did not develop thrombosis and had reasons other than HIT to explain thrombocytopenia. IgM/A antibodies did not increase microparticle penetration, but increased annexin‐V binding.Conclusions: The anti‐PF4/heparin EIA has high (∼99%) sensitivity for HIT. However, only about half of EIA‐positive patients are likely to have HIT. Anti‐PF4/heparin antibodies of IgM/A class and non‐PF4‐dependent antigens have only a minor role in HIT.
Programming Unplugged: Bridging CS Unplugged Activities Gap for Learning Key Programming Concepts

Computer Science (CS) unplugged is a set of learning activities designed to explain CS concepts without using a computer. These activities have been used globally especially during CS outreach programs. It was used during these programs to attract middle and high school students to major in CS. With this knowledge in mind, we initiated a summer camp program involving local middle and high school girls using newly developed CS unplugged activities. The aim of these activities was to teach and simplify key programming concepts, we named these activities Programming Unplugged (PU). The set of activities developed focused on simplifying programming for newcomers. We had measured the success of the activities and the camp using surveys, and projects developed by the students. The result shows that the students have enjoyed the camp and will likely recommend it to their friends. Also, we noticed that most of the CS concepts introduced during PU activities were used in the student's projects.
Modeling Joint Defaults in Correlation-Sensitive Instruments

This paper presents a simple model for joint defaults and shows how it can be applied to pricing and risk-managing instruments that are sensitive to credit correlation, from simple repos to collateralized debt obligations. The model relies on a conservative and intuitive representation of a systematic factor as a chain of dependencies running through the whole economy. This allows capturing the concentration of defaults in time and endogenously produces dynamics of default correlation as the model output rather than its input.
Leisure time physical activity and health-related behaviours after liver transplantation: a prospective, single-centre study

Introduction Leisure time physical activity is of proven significance in surveys of fitness levels in various patient groups. Low physical functioning may affect recovery after liver transplantation (LTx). Aim To assess patients’ leisure time activity and health-related habits after transplantation. Material and methods One hundred and seven patients after LTx were included. They were divided into groups depending on aetiology of liver problem and the period after LTx. Minnesota Leisure Time Physical Activity Questionnaire (MILTPAQ) and Health Behaviour Inventory (HBI) were applied. Results Neither the primary indication for the procedure nor the period after surgery had a significant relationship with physical activity assessed with MILTPAQ; however, activity was lower in females than males (1804.3 ±1848.9 vs. 2619.9 ±2067; p = 0.03). Age at survey/surgery was inversely associated with higher activity (p = 0.02 and p = 0.03, respectively). Health Behaviour Inventory analysis showed a correlation between all four of its domains and age at transplantation/survey (p < 0.001 for both). There was a negative correlation between positive mental attitude and body mass index (BMI). Conclusions The primary indications for grafting and, surprisingly, the period after surgery did not seem to be related to the patients’ physical activity in leisure time. Younger and leaner patients appeared to understand the standards of healthy behaviour better and implement them in their daily activities. As higher BMI are associated with a negative mental attitude in patients after LTx, a particular emphasis should be placed on proper counselling in this subgroup of patients.
Thermal infrared remote sensing of mineral dust over land and ocean: a spectral SVD based retrieval approach for IASI

Abstract. From the high spectral resolution thermal infrared observations of the Infrared Atmospheric Sounding Interferometer (IASI) mineral dust AOD (transferred from thermal infrared to 0.5 μm) is retrieved using a Singular Vector Decomposition of brightness temperature spectra. As infrared retrieval based on 8–12 μm observations, dust observation with IASI is independent from solar illumination. Through the linear combinations of suitable independent singular vectors weighted by their contribution to the observed signal, and a projection of different a-priori dust spectra on the resulting signal the dust can be well distinguished from the influence of surface emissivity and gas absorption. In contrast to lookup-table based single-channel retrievals this method takes advantage of the spectral shape of dust extinction and surface and atmosphere influence over the total 8–12 μm window band. Using different a-priori spectra for dust extinction allows also for an estimation of dust particle size in terms of effective radius based on the respective dust model size distributions. These dust models are also used for the transfer of infrared AOD to 0.5 μm. Four months of IASI observations covering Northern Africa and Arabia are used for evaluation. Two large scale dust events, one covering the Arabian Peninsula and adjacent parts of the Indian Ocean, the other over the Atlantic Ocean off the coast of West-Africa, are analysed and compared with other satellite images. They also show the good suitability of IASI data for dust observation at day and night. Monthly means derived from IASI observations represent well the known seasonal cycles of dust activity over Northern Africa and Arabia. IASI Dust AOD0.5 μm and AERONET coarse mode AOD0.5 μm are reasonably well (linearly) correlated with ρ=0.623. Moreover, comparison of time series of AERONET and IASI observations shows that the evolution of dust events is very well covered by the IASI observations. Rank correlation between dust effective radius and AERONET Angstrom exponent is −0.557 indicating the general capability of (qualitative) dust particle size information being provided by this method.
The Impact of Performance-Based Grants Management on Performance: The Centers for Disease Control and Prevention’s National Breast and Cervical Cancer Early Detection Program

Performance-based grants management is a strategy used by public agencies to improve performance and strengthen accountability by connecting annual award amounts to performance information. This study evaluates the impacts of a performance-based grants management process implemented by the U.S. Centers for Disease Control and Prevention to strengthen the effectiveness of its National Breast and Cervical Cancer Early Detection Program. The study uses panel data and interrupted time-series analysis over 10 years for 51 grantees. Results show partial and conditional effectiveness of the performance-based grants management process in strengthening performance. In particular, the implementation of the performance-based grants management system consistently improved the performance of those grantees for whom the targets were challenging. While prior research has found, in some cases, evidence of a positive impact of performance management practices in improving programs delivered directly by public organizations at the local level, this study examines the performance management–performance relationship in a more challenging context of a federal grants program delivered through a highly decentralized system.
Cortical bone stress distribution in mandibles with different configurations restored with prefabricated bar-prosthesis protocol: a three-dimensional finite-element analysis.

PURPOSE To evaluate stress distribution in different horizontal mandibular arch formats restored by protocol-type prostheses using three-dimensional finite element analysis (3D-FEA). MATERIALS AND METHODS A representative model (M) of a completely edentulous mandible restored with a prefabricated bar using four interforaminal implants was created using SolidWorks 2010 software (Inovart, São Paulo, Brazil) and analyzed by Ansys Workbench 10.0 (Swanson Analysis Inc., Houston, PA) to obtain the stress fields. Three mandibular arch sizes were considered for analysis, regular (M), small (MS), and large (ML). Three unilateral posterior loads (L) (150 N) were used: perpendicular to the prefabricated bar (L1); 30° oblique in a buccolingual direction (L2); 30° oblique in a lingual-buccal direction (L3). The maximum and minimum principal stresses (σ(max), σ(min)), the equivalent von Mises (σ(vM)), and the maximum principal strain (σ(max) ) were obtained for type I (M.I) and type II (M.II) cortical bones. RESULTS Tensile stress was more evident than compression stress in type I and II bone; however, type II bone showed lower stress values. The L2 condition showed highest values for all parameters (σ(vM), σ(max), σ(min), ɛ(max)). The σ(vM) was highest for the large and small mandibular arches. CONCLUSION The large arch model had a higher influence on σ(max) values than did the other formats, mainly for type I bone. Vertical and buccolingual loads showed considerable influence on both σ(max) and σ(min) stresses.
Which states enroll their Medicaid-eligible, citizen children with immigrant parents?

OBJECTIVE To identify which states achieve comparable enrollment rates for Medicaid-eligible, citizen children with immigrant and nonimmigrant parents. DATA SOURCE A total of 810,345 Medicaid-eligible, citizen children drawn from the 2008-2010 American Community Survey. STUDY DESIGN This study estimates a state fixed-effects probit model of uninsured status for Medicaid-eligible, citizen children. State and immigrant family interaction variables test whether citizen children in immigrant families have a higher probability of remaining uninsured compared to children in nonimmigrant families. Simulations predict the uninsured rates for Medicaid eligible children in immigrant and nonimmigrant families and rank states by the differences between the two groups. PRINCIPAL FINDINGS While some states have insignificant and near zero differences in predicted uninsured rates, many states have enrollment disparities reaching 20 percent points between citizen children with immigrant and nonimmigrant parents. CONCLUSIONS Many states have large differences in enrollment rates between their Medicaid-eligible, citizen children with immigrant and nonimmigrant parents. Addressing these enrollment disparities could improve the health status of citizen children in immigrant families and earn Children's Health Insurance Program Reauthorization Act bonus payments for many states.