Miracle-dz/UniFAR-FTUs huggingface dataset:
Award Number: W81XWH-12-1-0139 TITLE: Loss of PEDF: A Novel Mechanism of Antihormone Resistance in Breast Cancer

Introduction: Despite the benefits of endocrine therapies such as tamoxifen and aromatase inhibitors in treating estrogen receptor (ER) alpha-positive breast cancer, many tumors eventually become resistant. The molecular mechanisms governing resistance remain largely unknown. Pigment epithelium-derived factor (PEDF) is a multifunctional secreted glycoprotein that displays broad anti-tumor activity based on dual targeting of the tumor microenvironment (anti-angiogenic action) and the tumor cells (direct anti-tumor action). Recent studies indicate that PEDF expression is significantly reduced in several tumor types, including breast cancer, and that its reduction is associated with disease progression and poor patient outcome. In the current study, we investigated the role of PEDF in the development of endocrine resistance in breast cancer. Methods: PEDF mRNA and protein levels were measured in several endocrine-resistant breast cancer cell lines including MCF-7:5C, MCF-7:2A, and BT474 and in endocrine-sensitive cell lines MCF-7, T47D, and ZR-75-1 using realtime PCR and western blot analyses. Tissue microarray analysis and immunohistochemistry were used to assess the PEDF protein level in tamoxifen-resistant breast tumors versus primary tumors. Lentiviruses were used to stably express PEDF in endocrine-resistant breast cancer cell lines to determine their sensitivity to tamoxifen following PEDF re-expression. Results: We found that PEDF mRNA and protein levels were dramatically reduced in endocrine-resistant MCF-7:5C, MCF-7:2A, and BT474 breast cancer cells compared with endocrine-sensitive MCF-7, T47D, and ZR-75-1 cells, and that loss of PEDF was associated with enhanced expression of pERa and the receptor tyrosine kinase rearranged during transfection (RET). Importantly, we found that silencing endogenous PEDF in tamoxifen-sensitive MCF-7 and T47D breast cancer cells conferred tamoxifen resistance whereas re-expression of PEDF in endocrine-resistant MCF-7:5C and MCF-7:2A cells restored their sensitivity to tamoxifen in vitro and in vivo through suppression of RET. Lastly, tissue microarray studies revealed that PEDF protein was reduced in ~52.4% of recurrence tumors (31 out of 59 samples) and loss of PEDF was associated with disease progression and poor patient outcome. Conclusion: Overall, these findings suggest that PEDF silencing might be a novel mechanism for the development of endocrine resistance in breast cancer and that PEDF expression might be a predictive marker of endocrine sensitivity.
Preparation for motherhood : Home based maternal and newborn care for first time mothers

Mothers may not feel adequately prepared for parenthood if they are situated in an unsupported environment. In the postpartum period, women need more information on the baby and herself care. Community nurses play a critically essential role during the development of mothers' skills. Aim: is to enhance knowledge and skills among first time mothers for caring their-self and their newborn during postnatal period. A quasiexperimental design was conducted at postnatal department, postnatal outpatient clinic in Suez Canal university hospitals, followed by a telephone interview at 2 weeks after birth. Data was collected using structured interview questionnaire sheet, includes socio demographic data, mother's knowledge, and reporting practice regarding self-care and their newborn care during post-partum period before and after educational session. The study is consisted of (103) postnatal women. Results: Concerning post natal self care, 82% of mothers had incorrect knowledge about components of post-partum self-care. Mothers' total self-care and newborn care practices and knowledge during postpartum period were improved after program application Conclusion: First-time mothers whose didn't better prepare for motherhood may be considered a at risk group. Educational session was effective to increase the knowledge and practice regarding maternal and newborn care for first time mothers Recommendation: Conducting an educational program for mothers-especially for first time mothers must be started during late pregnancy to inform primigravida about self-care during postnatal period.
LIMSI-MULTISEM at the IJCAI SemDeep-5 WiC Challenge: Context Representations for Word Usage Similarity Estimation

We present the LIMSI-M ULTI S EM system submitted to the IJCAI-19 SemDeep-5 WiC challenge. The system measures word usage similarity in sentence pairs. We experiment with cosine similarities of word and sentence embeddings of different types, and with features based on in-context substitute annotations automatically assigned to WiC sentence pairs. The model with the highest performance on the WiC development set uses a combination of cosine similarities from different embedding types. It obtains an accuracy of 66.7 on the shared task test set and is ranked third among the participating systems.
Ginger (Zingiber officinale Roscoe) in the Prevention of Ageing and Degenerative Diseases: Review of Current Evidence

Currently, the age of the population is increasing as a result of increased life expectancy. Ageing is defined as the progressive loss of physiological integrity, which can be characterized by functional impairment and high vulnerability to various types of diseases, such as diabetes, hypertension, Alzheimer's disease (AD), Parkinson's disease (PD), and atherosclerosis. Numerous studies have reported that the presence of oxidative stress and inflammation contributes to the development of these diseases. In general, oxidative stress could induce proinflammatory cytokines and reduce cellular antioxidant capacity. Increased oxidative stress levels beyond the production of antioxidant agents cause oxidative damage to biological molecules, including DNA, protein, and carbohydrates, which affects normal cell signalling, cell growth, differentiation, and apoptosis and leads to disease pathogenesis. Since oxidative stress and inflammation contribute to these diseases, ginger (Zingiber officinale Roscoe) is one of the potential herbs that can be used to reduce the level of oxidative stress and inflammation. Ginger consists of two major active components, 6-gingerol and 6-shogaol, which are essential for preventing oxidative stress and inflammation. Thus, this paper will review the effects of ginger on ageing and degenerative diseases, including AD, PD, type 2 diabetes mellitus (DM), hypertension, and osteoarthritis.
Spiritual kinship ( comparatico ) as social capital : a study of Calabrian – Australian families living in Adelaide , South Australia

Introduction Pierre Bourdieu (1986, 1997) has been one of the main contributors to the development of social capital theory. Through his typology of capitals (economic, social, cultural and symbolic), Bourdieu argues that social capital is deployed in the reproduction of social class privilege and inequalities. According to Reynolds (2010), his theory has been particularly instrumental in understanding how individuals belonging to subordinate groups might improve their socio-economic status by deploying and investing in a range of different capitals. This theory has prompted many scholars to explore the relationship between ethnicity and social capital (Cheong 2005; Dwyer 2006; Evergeti and Zontini 2006; Goulbourne and Solomos 2003; Portes 1998; Zontini 2007).
of Managing Projects in Business Public funding , perverse incentives , and counterproductive outcomes

Purpose – The purpose of this paper is to explore the adverse incentives at the front end of governmentfunded projects with concentrated benefits and no liabilities for the privileged groups. In particular, the author discusses the risk of perverse incentives of the types typically found in the development aid sector that results in counterproductive outcomes. Design/methodology/approach – The paper uses a simple conceptual framework based on agency theory. A qualitative, case-based approach with purposive sampling was chosen for the empirical part of the study. Eight Norwegian projects were selected because incentive problems were to be expected, and one development aid project served as a reference case. Findings – The paper finds that low strategic project success corresponded well with the terms of financing. There were clear indications of agency problems, in three cases to the extent that the incentives turned perverse. The paper concludes with a discussion of relevant measures to prevent the emergence of perverse incentives. Originality/value – The paper contributes to an improved understanding of the incentives related to public project initiation and selection, which is an under-researched topic and generally not included in formal project governance schemes. The research should therefore be useful to scholars as well as practitioners within the field of project governance.
Résumé Améliorer l ’ évaluation de l ’ ef cacité des soins in rmiers

Pour établir une solide base de connaissances servant à orienter la pratique, il est essentiel de pouvoir évaluer l’ef cacité des soins in rmiers. Les nombreuses études qui ont été menées sur le sujet visaient à évaluer les interventions en fonction des résultats escomptés. Toutefois, même si les résultats qu’elles présentent sont encourageants, ces études ne fournissent pas un portrait exhaustif et réaliste de l’utilité des soins in rmiers, ni ne tiennent compte des caractéristiques des patients ou de l’exécution des soins. Le choix des résultats ne re ète pas non plus les bienfaits directs découlant des soins in rmiers. Cet article traite des méthodes de recherche évaluative susceptibles de mettre en lumière le rôle unique des soins in rmiers dans un cadre réaliste et quotidien; les auteures fournissent des exemples concrets pour illustrer leur propos.
Effects of Phytoplankton Growth Phase on Settling Properties of Marine Aggregates

Marine snow aggregates often dominate carbon export from the surface layer to the deep ocean. Therefore, understanding the formation and properties of aggregates is essential to the study of the biological pump. Previous studies have observed a relationship between phytoplankton growth phase and the production of transparent exopolymer particles (TEP), the sticky particles secreted by phytoplankton that act as the glue during aggregate formation. In this experimental study, we aim to determine the effect of phytoplankton growth phase on properties related to aggregate settling. Cultures of the diatom Thalassiosira weissflogii were grown to four different growth phases and incubated in rotating cylindrical tanks to form aggregates. Aggregate excess density and delayed settling time through a sharp density gradient were quantified for the aggregates that were formed, and relative TEP concentration was measured for cultures before aggregate formation. Compared to the first growth phase, later phytoplankton growth phases were found to have higher relative TEP concentration and aggregates with lower excess densities and longer delayed settling times. These findings may suggest that, although particle concentrations are higher at later stages of phytoplankton blooms, aggregates may be less dense and sink slower, thus affecting carbon export.
Combined effect of docetaxel and anthocyanins on triple negative breast cancer cells

Anthocyanins are polyphenolic compounds, which can be found in a large number of food and beverages, being an integral part of the human diet. These compounds play an important role in health, specifically in cancer prevention. Therefore, some studies have been focused on the evaluation of anthocyanins selective cytotoxicity on breast cancer, namely on triple negative breast cancer (TNBC). Docetaxel (DT) is a mitotic inhibitor used on the treatment of TNBC and its mechanism of action is similar to the mechanism of anthocyanins on MDA-MB-231 cells (TNBC cell line). The present study aimed to evaluate the isolated anti-proliferative potential of three anthocyanins: cyanidin (C3G), delphinidin (D3G) and malvidin-3-O-glucosides (M3G) and one anthocyanidin, luteolinidin (LT), on MDA-MB-231 cells, as well as, assess the combined effect of the anthocyanins with a dose-effect curve with DT. Cytotoxicity was assessed using the MTT assay. The Chou-Talatay method was used to evaluate the individual and combined effect of these compounds. Of the four anthocyanins tested, D3G was the only one that showed a dose-effect curve. Thus, the remaining anthocyanins were excluded from the combination experiments. D3G-DT combination produced a moderate synergistic effect on MDA-MB-231 cells proliferation when the inhibition concentration was higher. This synergistic effect allows a reduction of the docetaxel concentration. Therefore, D3G may be a possibility to be consider in DT chemotherapy in a combined therapeutic or dietary supplementation to reduce deleterious side effects of DT. However, is still necessary to study the effect of D3G-DT combination on healthy breast cells.
Designing emotion-aware in-car interactions for unlike markets

Interior cameras and other sensors facilitate affective automotive UIs reacting to the driver's detected emotional state and providing customized support. Previous research mainly presents single prototypes designed in western countries. A comprehensive view of relevant use cases and possible cultural differences between markets, however, is missing. This is particularly important as the significance of emotions is quite different between, e.g., western and eastern cultures. We present use case clusters for affective in-car UIs based on ideation workshops with German and Chinese participants. Our focus lies on the requirements arising from cultural differences, such as more rule-consistent driving in Germany or more important social components in China. Our ideation approach aims to enrich use cases for empathetic vehicles with the user's culture in mind. The use case clusters we present can inspire future concepts for improving user experience through affective interaction and for boosting acceptance by observing cultural peculiarities.
Rapid Protocol for in Vitro Multiplication of Citrus limonia Osbeck Rootstock

Rangpur lime (Citrus limonia Osbeck) is the most used rootstock in the world and in India, particularly in the state of Andhra Pradesh on account of its superior performance over other rootstocks. However, plants produced from seedlings are not used in orchards due to variations caused by polyembryony. To overcome such variation, in vitro propagation of Rangpur lime was performed using nodal segments and shoot tips as explants. After surface sterilization, the explants were inoculated on Murashige and Skoog (MS) medium supplemented with 3% sucrose, 100 mg/L benomyl and 250 mg/L streptomycin. The most effective concentrations of auxin ( -naphthalene acetic acid; NAA), cytokinin (6-benzyl adenine; BA) and gibberellic acid (GA3) for in vitro shoot induction and multiplication in Rangpur lime rootstock were determined. Almost all NAA and BA treatments resulted in almost 100% shoot induction except for at 0.0 and 0.1 mg/L NAA and at 1.5 and 2 mg/L BA. Nodal segments induced a higher percentage of explant response with longer shoots in a shorter period of time than shoot tips, which produced more shoots and leaves than nodal segments. The effect of different BA and NAA concentrations on various parameters of proliferation were studied. Full-strength MS medium produced more regenerated shoots and leaves per shoot than half-strength MS medium. In addition, longer shoots formed with 0.1 mg/L GA3 than culture medium without this plant growth regulator. _____________________________________________________________________________________________________________
Bronchoscopic balloon dilatation in the management of bronchial stenosis following lung transplantation

ee front matter & 2006 med.2006. 04.019 ng author. Tel. /fax: +3 ess: jgracia@separ.es (J Summary Background: Bronchial stenosis (BS) is currently found in 7–15% of lung transplantation (LT) recipients. Current treatment strategies have included Nd:Yag laser, cryotherapy, bougie dilatation and stent placement. Bronchoscopic balloon dilatation has been used as alternative treatment in a few cases with controversial results. This is a study to prospectively assess the efficacy of bronchoscopic balloon dilatation as a first step in the management of post-LT BS. Methods: From January 1995 to December 2002, bronchoscopic balloon dilatation was evaluated as first therapeutic option in all consecutive LT patients with BS. Symptoms, pulmonary function tests, airway diameter and use of other therapeutic techniques were evaluated. Results: A total of 10 out of 284 anastomed airways (3.5%) in 9 out of 152 LT patients were included in the study and follow-up lasted from 6 to 81 months. Dilatation of all but one BS met with initial success: increase of both luminal dimensions and forced vital capacity (P 1⁄4 0:01), and relief of symptoms. Bronchoscopic balloon dilatation long-term follow-up showed effective results in 5 out of 10 (50%) bronchial stenoses, after an average of 4 bronchoscopic balloon dilatation procedures (range 1–8). No severe complications were observed. Stent placement was required in the other 5 bronchial stenoses.
Effect of inclusion of sodium butyrate, calcium propionate or sodium monensin in the starter feed on ruminal parameters and forestomach development in dairy calves

The objective of this study was the evaluation of the inclusion of calcium propionate, sodium butyrate and sodium monensin in the starter concentrate on ruminal parameters and forestomach development in dairy calves. Fifteen newborn Holstein calves were rumen cannulated and housed in individual stalls until ten weeks old, with free access to water, fed 4 liters of milk per day, split in two meals, and starter concentrate ad libitum containing sodium butyrate (0.15%), sodium monensin (30 ppm) or calcium propionate (0.15%). Starting at the fourth week of life, before and 2 hours after the morning feeding, ruminal fluid samples were taken weekly to determine the pH, short-chain fatty acids and ammonia-N. After 10 weeks, the animals were slaughtered to assess the forestomach growth. The rumen pH was affected by sampling time and the additives used in the starter concentrate. The total short-chain fatty acids concentration and each fatty acid concentration, were was not affected by the additives. However, except for molar concentration of acetic acid, all rumen fermentation parameters were affected by sampling time. The total forestomach weight and the average weight of each compartment and the maximum reticulum-rumen capacity were not affected by additives supplied in the starter concentrate. No significant effects of the additives were observed on the height, width and number of papillae of the ruminal epithelium. The inclusion of these additives in starter concentrate had no effect on most of the ruminal parameters and forestomach development
Evolutionary Algorithms using Combined Objective and Novelty Search in Unconstrained Space

Novelty search, which incentivizes the evolution of novel rather than fit behaviors, has shown to be effective at solving deceptive problems in constrained behavior spaces. However, in large behavior spaces with a required goal, novelty search can struggle to evolve solutions in a timely manner. We combine novelty search with an objective search to solve deceptive problems in an unconstrained environment. Our experiments add to existing research about the limitations of novelty search and show that a blended objective + novelty search is more efficient than either search alone in unbounded, deceptive behavior spaces.
RELATED HASHTAG COMMUNITY DETECTION

Recently, more and more users would like to collect and provide information about news topics in Twitter, which is one of the most popular microblogging services. Virtual communities defined by hashtags in Twitter are created for exchanging information about the news topic. Finding influential Twitter users in these communities related to a news topic would help us understand why some opinions are popular, and get valuable and reliable information for the news topic. In this paper, we propose a new approach to detect news-topic-related user communities defined by hashtags based on characteristic co-occurrence word detection. We also propose RetweetRank and MentionRank to find two types of influential Twitter users from these news-topic-related communities based on user’s retweet and mention activities. Experimental results show that our characteristic co-occurrence word detection methods could detect words which are highly relevant to the news topic. RetweetRank could find influential Twitter users whose tweets about the news topic are valuable and more likely to interest others. MentionRank could find influential Twitter users who have high authority on the news topic. Our methods also outperform other related methods in evaluations.
EFFECT OF AUSTRIAN PINE ON NATURALNESS AND SUCCESSION OF VEGETATION IN RECLAIMED BAUXITE

Phytosociological and nature conservation assessment of the herb layer of 6-, 15and 20-yearold post-mining Austrian pine stands was conducted in reclaimed bauxite quarries in Hungary. Great differences among the vegetations were found. Disturbance-tolerant species were dominant, subdominant and subordinated in the youngest, middle-aged and oldest pine stand, respectively. In parallel, proportion of the species characteristic for natural habitats increased gradually, leading to growing diversity and naturalness. The increasing pine cover reduced the species number and the coverage of herb layer. Postmining flora differed significantly from both the potential mature oak forest vegetation of the areas and from the associations developed through regenerative succession on clear-cut areas of oak forests. Vegetation of the reclaimed quarries had lower naturalness: relative abundances of disturbance-tolerant and ruderal species were higher, but ratio of natural broad-leaved forest’s species was smaller than in the potential vegetation. Similar differences were shown by comparison of the flora of bauxite quarries with the same-aged stages of regenerative succession of oak forests. In pine stands the repression of weeds parallel to the spreading of natural competitors was slower, and natural geophytes and protected species remained absent. Deficiency of propagule sources in reclaimed areas could contribute to the retentive effect of Austrian pine on vegetation succession.