Miracle-dz/UniFAR-FTUs huggingface dataset:
Use of Different Methods of Intramedullary Nailing for Fixation of Distal Radius Fractures: A Retrospective Analysis of Clinical and Radiological Outcomes

Background We aimed to evaluate the clinical and radiologic outcomes of using Sonoma WRx versus Micronail intramedullary nailing for the fixation of distal radius fractures. Material/Methods A total of 68 patients with primarily extra-articular and simple intra-articular fractures of the distal radius who underwent intramedullary distal radius fixation using Sonoma WRx (n=39) or Micronail (n=29) intramedullary nails were enrolled in the study. The clinical outcome measures included the range of motion (ROM), visual analog scale (VAS), functional outcomes (patient-reported Disabilities of the Arm, Shoulder and Hand [DASH] score and clinician-based Gartland-Werley score), radiographic scores (Stewart score), and parameters related to the quality of radiographic reduction and complications (radial inclination, volar tilt, radial height, and radio-ulnar variance). Results Significantly higher DASH (15.0±3.3 vs. 8.3±1.5, p<0.001) and Gartland-Werley (4.9±5.4 vs. 2.9±4.2, p=0.029) scores, longer scopy time (21.0±3.9 min vs. 15.8±2.5 min, p<0.001), lower ROM for wrist extension (69.5±4.4° vs. 77.1±7.6°, p<0.001), higher ROM for wrist supination (81.9±5.1° vs. 78.7±3.1°, p<0.001), and higher complications rates (37.9% vs. 15.4%, p=0.034) were noted in the Micronail group compared to those in the Sonoma WRx group. Conclusions Our findings revealed that Sonoma WRx and Micronail implants were equally effective and useful minimally invasive options for treating distal radius fractures. Further, we consider Sonoma WRx superior in terms of shorter operative time, lower complication rates, and better functional outcome scores.
Increases in quantities consumed in drinking occasions in New Zealand 1995-2004.

INTRODUCTION AND AIMS Significant changes have occurred in the alcohol environment in New Zealand recently and there has been debate about how trends in alcohol consumption may currently look. This paper reports trends in drinking over three general population samples in New Zealand. DESIGN AND METHODS Three nationally representative comparable surveys were analysed for trends in: prevalence of drinking, typical occasion quantity, annual frequency and heavier drinking (5+ drinks). Analyses assessed the mean difference of the measures at each year point. Adjustments for multiple comparisons were made. Analysis was undertaken for age and separately for gender. RESULTS Increases in quantities consumed on a typical occasion occurred for the majority of age groups between 1995 and 2000. Women were as likely as men to increase the quantities they consumed. Observing differences between age groups found that young people tended to show the greatest increases in quantity (including heavier drinking) and frequency of consumption between 1995 and 2000. Drinking levels remained relatively stable between 2000 and 2004 with the exception of increases in abstention for some of the younger groups and increases in quantities consumed and heavier drinking among some of the older men. DISCUSSION AND CONCLUSIONS Increases in quantities consumed per occasion have occurred almost across the board between 1995 and 2000 in New Zealand. Women were as likely as men to increase the quantities they consumed. Young people tended to show the greatest increases in quantity (including heavier drinking) and frequency of consumption between 1995 and 2000. Drinking remained relatively stable between 2000 and 2004.
Accurate Calorimetric Switching Loss Measurement for 900 V 10 m $\Omega$ SiC mosfets

This letter presents and evaluates three accurate (<inline-formula><tex-math notation="LaTeX">$\pm$</tex-math> </inline-formula>20 %) calorimetric switching loss measurement methods, which are capable of measuring hard- and soft-switching losses at high speed (20–25 min/point) compared to other calorimetric methods. A comprehensive switching loss measurement data accuracy analysis is done, setting the benchmark for the accuracy analysis of switching loss data. The high accuracy in the switching loss data is obtained by a high ratio of switching losses to total measured losses in the Device Under Test. This is achieved by using a full-bridge configuration, where the conduction losses are reduced up to 80% in the Device Under Test by utilizing the duty cycle as an additional degree of freedom compared to a half-bridge configuration. Furthermore, the proposed calorimetric methods yield more reliable switching loss data than electrical methods, particularly than the double pulse test. Switching loss data are presented for the 900 V, 75 A, 10 m<inline-formula><tex-math notation="LaTeX">$\Omega$ </tex-math></inline-formula> SiC <sc>mosfet</sc>s from CREE, that are one of the first discrete SiC <sc>mosfet</sc>s to come with a TO-247-4 package.
Four Years Old Children's Sleep: What can we obtain by using wearable measuring devices at their home?

We have developed a sleep measuring system which can measure any subject at any pace. This system is consisted with wearable (size: 40×39×8mm, weight: 14g) acceleration and ECG measuring device and data analyzing software which able to output times in bed, sleep duration, NREM sleep proportion, sleep posture distribution and changing times, measures of autonomic system's activity, frequency of respiration and its variation, and results of sleep apnea detection. In this paper, we had measured 4 y.o. children and analyzed their sleep at home.
Human herpesvirus-6 infection after lung and heart-lung transplantation: a prospective longitudinal study

Background. Although human herpesvirus (HHV)-6 is now recognized as a frequent pathogen after transplantation, the real impact of this infection in patients undergoing transplantation remains unclear. Methods. During 27 months, 30 consecutive heart–lung- and lung-transplant recipients were included on the day of transplantation and prospectively followed during 100 days for HHV-6 infection. Results. HHV-6 infection occurred in 20 (66%) patients after a median delay of 18 days after transplantation. The virus was detected by polymerase chain reaction or culture, or both, in 15.7 % of blood specimens, in 14.5% of bronchoalveolar lavage fluids, and in many organs at postmortem examination; it was found by culture in eight patients. No clinical manifestations could clearly be associated with HHV-6 alone. However, patients with HHV-6 infection had a higher mortality rate than patients without HHV-6 infection (7 of 20 vs. 0 of 10; P =0.04), and all the deceased patients died during periods of HHV-6 infection. We did not observe higher incidence of infectious or graft-rejection episodes in HHV–6-positive patients. However, eight of nine viral or fungal infections occurred during HHV-6 infection and three were directly responsible for death. Conclusion. Although frequently detected after transplantation, HHV-6 was not associated with any specific clinical manifestation. The higher mortality rate observed in patients with HHV-6 infection was not related to a higher incidence of bacterial infections or graft rejection but might be associated with more viral and fungal infections.
Checkpoint Ensembles: Ensemble Methods from a Single Training Process

We present the checkpoint ensembles method that can learn ensemble models on a single training process. Although checkpoint ensembles can be applied to any parametric iterative learning technique, here we focus on neural networks. Neural networks' composable and simple neurons make it possible to capture many individual and interaction effects among features. However, small sample sizes and sampling noise may result in patterns in the training data that are not representative of the true relationship between the features and the outcome. As a solution, regularization during training is often used (e.g. dropout). However, regularization is no panacea -- it does not perfectly address overfitting. Even with methods like dropout, two methodologies are commonly used in practice. First is to utilize a validation set independent to the training set as a way to decide when to stop training. Second is to use ensemble methods to further reduce overfitting and take advantage of local optima (i.e. averaging over the predictions of several models). In this paper, we explore checkpoint ensembles -- a simple technique that combines these two ideas in one training process. Checkpoint ensembles improve performance by averaging the predictions from "checkpoints" of the best models within single training process. We use three real-world data sets -- text, image, and electronic health record data -- using three prediction models: a vanilla neural network, a convolutional neural network, and a long short term memory network to show that checkpoint ensembles outperform existing methods: a method that selects a model by minimum validation score, and two methods that average models by weights. Our results also show that checkpoint ensembles capture a portion of the performance gains that traditional ensembles provide.
Olfactory Functions in Asymptomatic Carriers of the Huntington Disease Mutation

Huntington's disease (HD) is a neurodegenerative disorder initially affecting the basal ganglia and especially the head of the caudate nucleus. Neuropsychological research has indicated that olfactory dysfunction may appear early in HD, prior to the onset of significant motor or cognitive dysfunction. The aim of this study was to examine whether asymptomatic carriers of the Huntington disease mutation also exhibit olfactory dysfunction. To address this issue we presented an extensive olfactory test battery comprising tasks assessing olfactory sensitivity, intensity discrimination, quality discrimination, episodic odor memory, and odor identification, to a group of gene carriers and nonmutation carriers of the disease. The results showed that gene carriers were selectively impaired in discriminating odor quality, although performance did not differ from noncarriers across the other tasks. The role played by striatum and then in particular the caudate nucleus for olfactory processing in general, and for odor quality discrimination in particular, is discussed.
Acute Acne Flare following Isotretinoin Administration: Potential Protective Role of Low Starting Dose

E-Mail karger@karger.ch www.karger. com flammatory flares may occur during the first 3–5 weeks of treatment [5] . The flares manifest by paradoxical aggravation of acne, notably of the inflammatory component. As a rule, mild forms of flare resolve spontaneously and do not require change or discontinuation of treatment. Sometimes, inflammatory flare-up can be particularly severe and may distress the patient. These severe flares must be distinguished from acne fulminans, which is accompanied by systemic signs, articular symptoms and biochemical signs of inflammation [6] . Severe inflammatory acne deterioration may lead to scar development. In severe cases, systemic steroid therapy and either reduction or discontinuation of isotretinoin are necessary. The actual responsibility of oral isotretinoin in the extent of these flares is not proven. However, improvements usually occur upon discontinuation of isotretinoin, while increases in dosage can aggravate the inflammation. In order to avoid acne flares, many authors suggest to start oral isotretinoin treatment with a dose of no more than 0.5 mg/kg/ day for the first month, and then to increase the daily dosage to 1 mg/kg [7] . With the present observational study, we wanted to assess whether initial daily doses ! 0.5 mg/kg can further reduce the occurrence of flares during the first month of isotretinoin administration. Between October 2002 and October 2007, 132 acne patients (67 males and 65 females, mean age 20.3 years) whose clinical features are reported in table 1 , group 1, were treated with oral isotretinoin at an initial daily dose ̂ 0.2 mg/kg. The dosage was subsequently increased by 5 mg every 2 weeks, until the maximum tolerated dose (between 0.5 and 1 mg/kg of body weight) was reached. All patients were treated until acne clearing, without exceeding a total cumulative dose of 150 mg/kg. With the aim of
Serum testosterone in women as measured by an automated immunoassay and a RIA.

Taieb et al. (1) in their recent report in Clinical Chemistry described the relationship of serum testosterone concentrations measured by 10 immunoassays and by isotope-dilution gas chromatography–mass spectrometry (ID/GC-MS). Automated immunoassays fared badly, but RIAs agreed well with the ID/GC-MS. In contrast to our findings, Taieb et al. (1) reported, in women, increased serum testosterone as assayed in the AutoDelfia immunoassay system (Perkin-Elmer). Between November 1, 2002, and February 28, 2003, we found for 2057 women a mean (median) testosterone of 2.1 (1.6) nmol/L by AutoDelfia, similar to the values of 1.7 (1.4) nmol/L for 2180 different female samples assayed consecutively in our routine using the Orion Diagnostica RIA between November 1, 2001, and February 28, 2002. By contrast, Taieb et al. (1) reported mean concentrations of ∼5 nmol/L in the female samples measured by the AutoDelfia. In the same time periods, consecutive male samples had mean (median) values of 16.7 (14.8) nmol/L by AutoDelfia (n = 1447) and 13.9 (12.9) nmol/L by the Orion (n = 1505). Again, the difference between the automated … [↵][1]aAuthor for correspondence. Fax 33-1-4249-4280; e-mail philippe.boudou{at}sls.ap-hop-paris.fr. [1]: #xref-corresp-2-1
Toxoplasma gondii Prevents Chromatin Remodeling Initiated by TLR-Triggered Macrophage Activation1

Macrophages infected with the opportunistic protozoan Toxoplasma gondii are unable to up-regulate many proinflammatory cytokine genes, including TNF (TNF-α), upon stimulation with LPS and other TLR ligands. In this study, we examined the influence of T. gondii on transcription factors associated with TNF-α transcription, as well as phosphorylation and acetylation of histone H3 at distal and proximal regions of the TNF-α promoter. During LPS stimulation, we found that Toxoplasma blocks nuclear accumulation of transcription factor c-Jun, but not that of cAMP response element-binding protein or NF-κB. However, chromatin immunoprecipitation studies revealed that binding of all of these transcription factors to the TNF promoter was decreased by T. gondii infection. Furthermore, the parasite blocked LPS-induced Ser10 phosphorylation and Lys9/Lys14 acetylation of histone H3 molecules associated with distal and proximal regions of the TNF-α promoter. Our results show that Toxoplasma inhibits TNF-α transcription by interfering with chromatin remodeling events required for transcriptional activation at the TNF promoter, revealing a new mechanism by which a eukaryotic pathogen incapacitates proinflammatory cytokine production during infection.
Training impulsive children in the use of more efficient scanning techniques.

EGELAND, BYRON. Training Impulsive Children in the Use of More Efficient Scanning Techniques. CHILD DEVELOPMENT, 1974, 45, 165-171. Impulsive second-grade, inner-city children were trained to improve their search strategies on match-to-sample visual discrimination exercises. A second group of impulsives, using the same materials, was taught to delay their responses. Both groups showed significant increases in response time and decreases in errors on the Matching Familiar Figures test given immediately after training. While the group trained to delay responses showed an increase in errors on a delayed posttest given 2 months after training, the group trained to improve search strategies continued to maintain a low level of error responses. A control group did not show any change in error or latency scores. Both training groups showed improved performance on the vocabulary subtest of the Gates-MacGinitie Reading Test, and the group trained to improve search strategies also showed improvement on the comprehension subtest.
Collective Bargaining, Transfer Rights, and Disadvantaged Schools

Collective bargaining is common in American public education, but its consequences are poorly understood. We focus here on key contractual provisions—seniority-based transfer rights—that affect teacher assignments, and we show that these transfer rights operate to burden disadvantaged schools with higher percentages of inexperienced teachers. We also show that this impact is conditional: It is substantial in large districts, where decisions are likely to follow rules, but it is virtually zero in small districts, where decisions tend to be less formal and undesirable outcomes can more easily be avoided. The negative consequences are thus concentrated on precisely those districts and schools—large districts, high-minority schools—that have been the nation’s worst performers and the most difficult to improve.
Effect of patient decision aid was influenced by presurgical evaluation among patients with osteoarthritis of the knee.

BACKGROUND Decision aids help patients make total joint arthroplasty decisions, but presurgical evaluation might influence the effects of a decision aid. We compared the effects of a decision aid among patients considering total knee arthroplasty at 2 surgical screening clinics with different evaluation processes. METHODS We performed a subgroup analysis of a randomized controlled trial. Patients were recruited from 2 surgical screening clinics: an academic clinic providing 20-minute physician consultations and a community clinic providing 45-minute physiotherapist/nurse consultations with education. We compared the effects of decision quality, decisional conflict and surgery rate using Cochran-Mantel-Haenszel χ2 tests and the Breslow-Day test. RESULTS We evaluated 242 patients: 123 from the academic clinic (61 who used the decision aid and 62 controls) and 119 from the community clinic (59 who used the decision aid and 60 controls). Results suggested a between-site difference in the effect of the decision aid on the patients' decision quality (p = 0.09): at the academic site, patients who used the decision were more likely to make better-quality decisions than controls (54% v. 35%, p = 0.044), but not at the community site (47% v. 51%, p = 0.71). Fewer patients who used decision aids at the academic site than at the community site experienced decisional conflict (p = 0.007) (33% v. 52%, p = 0.05 at the academic site and 40% v. 24%, p = 0.08 at the community site). The effect of the decision aid on surgery rates did not differ between sites (p = 0.65). CONCLUSION The decision aid had a greater effect at the academic site than at the community site, which provided longer consultations with more verbal education. Hence, decision aids might be of greater value when more extensive total knee arthroplasty presurgical assessment and counselling are either impractical or unavailable.
Teacher Identity from a Bourdieuian Perspective

This paper draws on the work of Pierre Bourdieu to understand the resistance of teacher education graduates to their University learning and the alignment with the field of education. This is a perplexing and perennial problem in teacher education. Bourdieu’s theory offers concepts that allow this situation to be theorized through notions of identity and the wider social, cultural arena within which identity can be construed.
Reduction of P/Q‐type calcium channels in the postmortem cerebellum of paraneoplastic cerebellar degeneration with Lambert‐Eaton myasthenic syndrome

The aim of this study was to clarify whether autoimmunity against P/Q‐type voltage‐gated calcium channels (VGCCs) in the cerebellum was associated with the pathogenesis of paraneoplastic cerebellar degeneration (PCD) with Lambert‐Eaton myasthenic syndrome (LEMS). We used human autopsy cerebellar tissues from three PCD‐LEMS patients and six other disease patients including one with LEMS as the controls. We compared cerebellar P/Q‐type VGCC in these patients and controls for the amount and ratio of autoantibody‐channel complex using an 125I‐ω‐conotoxin MVIIC‐binding assay with Scatchard analysis, and their distribution using autoradiography. The quantity of cerebellar P/Q‐type VGCC measured by Scatchard analysis were reduced in PCD‐LEMS patients (63.0 ± 7.0fmol/mg, n = 3), compared with the controls (297.8 ± 38.9fmol/mg, n = 6). The ratio of autoantibody‐VGCC complexes to total P/Q‐type VGCCs measured by immunoprecipitation assay were increased in PCD‐LEMS patients. We analysed cerebellar specimens by autoradiography using 125I‐ω‐conotoxin MVIIC, which specifically binds to P/Q‐type VGCCs. In PCD‐LEMS cerebellum, the toxin binding sites of P/Q‐type VGCCs were markedly reduced compared with controls, especially in the molecular layer, which is the richest area of P/Q‐type VGCCs in the normal cerebellum. This suggests that P/Q‐type VGCCs of the cerebellar molecular layer is the immunological target in developing PCD‐LEMS.
Substrate integrated waveguide textile antennas as energy harvesting platforms

Textile multi-antenna systems are key components of smart fabric and interactive textile (SFIT) systems, as they establish reliable and energy-efficient wireless body-centric communication links. In this work, we investigate how their functionality can further be extended by exploiting their surface as an energy harvesting and power management platform. We provide guidelines for selecting an appropriate antenna topology and describe a suitable integration procedure. We demonstrate this approach by integrating two flexible solar cells, a micro-energy cell and a flexible power management system onto a well-chosen wearable substrate integrated waveguide cavity-backed textile slot antenna, without affecting its performance, to enable energy harvesting from solar and artificial light. In addition, the compact and highly-integrated harvesting module provides a terminal for connecting a thermoelectric generator, enabling thermal body energy harvesting. Measurements in a realistic indoor environment have demonstrated that this hybrid energy harvesting approach leverages a more continuous flow of scavenged energy, enabling energy scavenging in most of the indoor and outdoor scenarios.
Substitution of Conserved Residues within the Active Site Alters the Cleavage Religation Equilibrium of DNA Topoisomerase I*

Eukaryotic DNA topoisomerase I (Top1p) catalyzes the relaxation of supercoiled DNA and constitutes the cellular target of camptothecin (CPT). Mutation of conserved residues in close proximity to the active site tyrosine (Tyr727 of yeast Top1p) alters the DNA cleavage religation equilibrium, inducing drug-independent cell lethality. Previous studies indicates that yeast Top1T722Ap and Top1N726Hp cytotoxicity results from elevated levels of covalent enzyme-DNA intermediates. Here we show that Top1T722Ap acts as a CPT mimetic by exhibiting reduced rates of DNA religation, whereas increased Top1N726Hp·DNA complexes result from elevated DNA binding and cleavage. We also report that the combination of the T722A and N726H mutations in a single protein potentiates the cytotoxic action of the enzyme beyond that induced by co-expression of the single mutants. Moreover, the addition of CPT to cells expressing the double top1T722A/N726H mutant did not enhance cell lethality. Thus, independent alterations in DNA cleavage and religation contribute to the lethal phenotype. The formation of distinct cytotoxic lesions was also evidenced by the different responses induced by low levels of these self-poisoning enzymes in isogenic strains defective for the Rad9 DNA damage checkpoint, processive DNA replication, or ubiquitin-mediated proteolysis. Substitution of Asn726 with Phe or Tyr also produces self-poisoning enzymes, implicating stacking interactions in the increased kinetics of DNA cleavage by Top1N726Hp and Top1N726Fp. In contrast, replacing the amide side chain of Asn726 with Gln renders Top1N726Qp resistant to CPT, suggesting that the orientation of the amide within the active site is critical for effective CPT binding.