Miracle-dz/UniFAR-FTUs huggingface dataset:
SQUAMOUS-CELL EPITHELIOMA OF THE LIP: A STUDY OF FIVE HUNDRED AND THIRTY-SEVEN CASES

Of all the malignant neoplasms with which man is afflicted, few cause more concern and inconvenience than that of epithelioma of the lip. In the past, pathologists have been content to classify cancer of the lip as cancer, without any distinction as to the degree of malignancy. It is a well established fact that some cancers of the lip are fatal to patients and others are not. There must be a reason for this. One theory is that some persons are resistant to cancer, and this seems to be borne out in a certain percentage of cases. Undoubtedly, a large proportion of cancer cells are destroyed by the defense cells of the body; of these, the fibrous connective tissue cell is the most important, since it cuts off nourishment from the cancer cells. The endothelial leukocyte and lymphocyte evidently also play ah important role in the destruction of cancer cells,
Midodrine and tolvaptan in patients with cirrhosis and refractory or recurrent ascites: a randomised pilot study

Splanchnic arterial vasodilatation and subsequent sodium and water retention play an important role in cirrhotic ascites. Midodrine and tolvaptan have been used separately in these patients. However, there are no reports on the use of combination of midodrine and tolvaptan in the control of ascites. The aim of this study was to evaluate the safety and efficacy of midodrine, tolvaptan and their combination in control of refractory or recurrent ascites in cirrhotics.
Attitudes to service quality – the expectation gap

In the competitive environment in which hospitality businesses exist, the quality of service is a vital mechanism used to achieve a competitive advantage. Quality is a difficult construct to quantify however the ability to measure quality is key to assessing whether or not the industry provides the service consumers desire. Consumers hold the key to business survival and success. The aim of this study was to investigate how closely consumer expectations of service, and manager and staff perceptions of consumer expectations matched. The SERVQUAL model was used to identify those dimensions of service deemed to be important in assessing service quality. The results show that there is a gap between managers’ perceptions of consumers’ expectations and actual consumers’ expectations. The main implication for the hospitality industry is for managers to develop strategies which will meet consumers’ expectations of service quality.
Patterns of recurrence following complete cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in patients with peritoneal carcinomatosis of colorectal cancer

Background and Objectives CytoReductive Surgery (CRS) combined with Hyperthermic IntraPEritoneal Chemotherapy (HIPEC) has an established role in the treatment of peritoneally metastasized colorectal cancer. The aim of the study was to describe the recurrence patterns and to evaluate treatment options and related survival.
Wisteria floribunda agglutinin‐positive human Mac‐2 binding protein predicts the risk of HBV‐related liver cancer development

Wisteria floribunda agglutinin‐positive human Mac‐2 binding protein (WFA+‐M2BP) can be used to assess the degree of liver fibrosis, but few studies have investigated its prognostic utility. We evaluated whether serum WFA+‐M2BP can predict the development of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients.
Cutaneous Pustular Leukemoid Reactions in Trisomy 21

Abstract: We report two neonates with Down syndrome and postnatal leukemoid reactions who developed acute widespread pustular eruptions. The white blood cell (WBC) counts on the first day of life were markedly elevated, with blasts seen on examination of the peripheral blood smear. The skin eruptions progressed and became pustular. Viral and bacterial cultures were negative. Skin examination revealed pustules on an erythematous base on the cheeks, shoulders, trunk, and proximal extremities. Skin biopsy specimens showed an intraepidermal pustule with an inflammatory infiltrate including neutrophils, eosinophils, and mononuclear cells. The mononuclear cells had atypical, immature‐appearing nuclei. In patient 1, these cells were strongly myeloperoxidase positive on immunohistochemistry, indicating myeloid lineage. In patient 2, these cells were CD3‐positive T cells. Patient 1 received a 5‐day infusion of continuous cytarabine (ara‐C) secondary to high WBC counts and symptomatic hyperviscosity. During therapy, the high WBC count and the pustules resolved. The lesions of patient 2 improved with topical mometasone furoate and resolved as her WBC count decreased. Recently, similar cases have been reported. Transient myeloproliferative disorders, or leukemoid reactions, should always be considered when newborns with Down syndrome or trisomy 21 mosaicism develop a pustular eruption.
The role of autonomic dysfunction in predicting 1‐year mortality after liver transplantation

Model for end‐stage liver disease (MELD) score has been extensively used to prioritize patients for liver transplantation and determine their prognosis, but with limited predictive value. Autonomic dysfunction may correlate with increased mortality after liver transplant. In this study, two autonomic biomarkers, complexity and deceleration capacity, were added to the predicting model for 1‐year mortality after liver transplantation.
Pathobiology and Genetics of Neural Tube Defects

Summary: Purpose: Neural tube defects (NTDs), including spina bifida and anencephaly, are common congenital malformations that occur when the neural tube fails to achieve proper closure during early embryogenesis. Based on epidemiological and clinical data obtained over the last few decades, it is apparent that these multifactorial defects have a significant genetic component to their etiology that interacts with specific environmental risk factors. The purpose of this review article is to synthesize the existing literature on the genetic factors contributing to NTD risk.
The in vitro assessment of drug resistant malaria in Makurdi, North Central Nigeria.

Multi-drug resistant malaria parasite strains have spread to new areas that were once free of such strains. This study evaluated the specific in vitro sensitivities of some standard antimalarial drugs, against Plasmodium falciparum isolates in Makurdi, North Central Nigeria. The standard schizonts growth inhibition assays was used to study the in vitro activities of quinine, artesunate, and amodiaquine against 146 isolates in children aged 2-14 years. 100 % of isolates were in vitro sensitive to quinine, geometric mean effective concentration (EC)50 = 241.55 nM, EC90 = 676.08 nM, and EC99 = 993.12 nM; and artesunate, EC50 = 1.05 nM, EC90 = 2.42 nM, and EC99 = 3.16 nM. 1.37 % of isolates were resistant to amodiaquine, EC50 = 22.08 nM, EC90 = 66.22 nM and EC99 = 100.23 nM. Significant in vitro cross resistance was found at EC50 values of quinine-amodiaquine drug pair (r = + 0.342, P 0.05) or artesunateamodiaquine (r = + 0.088, P > 0.05). These results call for constant surveillance, to curb the spread of P. falciparum resistance to amodiaquine in Nigeria. Keywords: Drug resistance, Plasmodium falciparum , Malaria, Nigeria.
BK Polyoma Virus Allograft Nephropathy: Ultrastructural Features from Viral Cell Entry to Lysis

BK virions must enter the host cell and target their genome to the nucleus in order to complete their life cycle. The mechanisms by which the virions accomplish these tasks are not known. In this morphological study we found that BK virions localized beneath the host cell cytoplasmic membrane in 60–70‐nm, smooth (non‐coated) monopinocytotic vesicles similar to, or consistent with, caveolae. In the cytoplasm, the monopinocytotic vesicles carrying virions appeared to fuse with a system of smooth, vesicles and tubules that communicated with the rough endoplasmic reticulum and was continuous with the Golgi system. Membrane‐bound single virions and large tubulo‐reticular complexes loaded with virions accumulated in paranuclear locations. Occasional nuclei displayed virions within the perinuclear cisterna in association to the perinuclear viral accumulations. Tubular cells with mature productive infection had large nuclei, distended by daughter virions, whereas they lacked significant numbers of cytoplasmic virions. In addition to virally induced cell necrosis, there was extensive tubular cell damage (apoptosis and necrosis) in morphologically non‐infected tubules. The observed ultrastructural interactions between the BK virions and host cells are remarkably similar to viral cell entry and nuclear targeting described for SV40 virus.
Detection of the QRS complex, P wave and T wave in electrocardiogram

Electrocardiogram (ECG) provides useful information of the condition of the heart. Most automatic ECG diagnosis techniques require an accurate detection of the QRS complexes. In this project, two QRS detection methods are studied. The first method, the "So and Chan" method (H.H. So and K.L. Chan, 1997), is based on the maximum slope detection with the QRS onset selected when two successive values of the slope exceed the threshold. The second method is developed by J. Pan and W.J. Tompkins (1985). American Heart Association (AHA) ECG data files are used to test these two QRS detection methods. Our results show that the "So and Chan" method performs better than the "Pan and Tompkins" method. Further development continues on the "So and Chan" method. Based on the information of the identified QRS complexes, the P waves and the T waves are also be detected. ECG classification is then carried out using the autocorrelation. The classification algorithm is trained to recognize four types of beat.
Prevention of Programmed Hyperleptinemia and Hypertension by Postnatal Dietary ω-3 Fatty Acids

Fetal programming is now recognized as a key determinant of the adult phenotype, with major implications for adult-onset diseases including hypertension. Two mediators of fetal programming are maternal nutrition and fetal glucocorticoid exposure. Recent studies show that postnatal dietary manipulations can exacerbate programming effects, but whether programming effects can be attenuated by postnatal dietary manipulations, and thus provide a possible therapeutic strategy, is unknown. In this study, we tested the hypothesis that a postnatal diet enriched with long-chain omega-3 fatty acids attenuates programmed hyperleptinemia and hypertension. Pregnant rats were treated with dexamethasone (Dex) from d 13 to term, and offspring were cross-fostered to mothers on either a standard diet or a diet high in omega-3 fatty acids and remained on these diets postweaning. Maternal Dex reduced birthweight and delayed the onset of puberty in offspring. Hyperleptinemia (associated with elevated leptin mRNA expression in adipose tissue) and hypertension were evident in offspring by 6 months of age in Dex-exposed animals consuming a standard diet, but these effects were completely blocked by a high omega-3 diet. These results demonstrate for the first time that manipulation of postnatal diet can limit adverse outcomes of fetal programming, with programmed hyperleptinemia and hypertension prevented by a postnatal diet enriched with omega-3 fatty acids. This raises the possibility that dietary supplementation with omega-3 fatty acids may provide a viable therapeutic option for preventing and/or reducing adverse programming outcomes in humans.
Direct‐acting antiviral therapy decreases hepatocellular carcinoma recurrence rate in cirrhotic patients with chronic hepatitis C

Arrival of direct‐acting antiviral agents against hepatitis C virus with high‐sustained virological response rates and very few side effects has drastically changed the management of hepatitis C virus infection. The impact of direct‐acting antiviral exposure on hepatocellular carcinoma recurrence after a first remission in patients with advanced fibrosis remains to be clarified.
Primer on outcomes research

Outcomes research uses diverse inputs to examine innovative end results aimed to deliver quality patient care. Yet defining “outcomes research” remains a challenge, and its interpretation is often nuanced. In this review, we discuss the definition of outcomes research in the context of its historical evolution along with the rise of other similar types of research. We then discuss key considerations in interpreting the results of outcomes analysis. J. Surg. Oncol. 2014 110:489–493. © 2014 Wiley Periodicals, Inc.
Patient‐reported outcomes in patients co‐infected with hepatitis C virus and human immunodeficiency virus treated with sofosbuvir and velpatasvir: The ASTRAL‐5 study

The fixed‐dose combination of sofosbuvir and velpatasvir (SOF/VEL) is a ribavirin‐free pan‐genotypic regimen with high efficacy. We assessed the impact of SOF/VEL on patient‐reported outcomes (PRO) of HIV‐HCV co‐infected patients.
The Autonomic Nervous System: Morphological, Comparative, Clinical and Surgical Aspects

According to the publisher, this book represents the culmination of 25 years of study and original investigation by the author; indeed, it contains an enormous amount of varied, well-annotated data which undoubtedly will serve as a standard reference for many years to come. Unfortunately, there is little reference to newer physiologic and pharmacologic concepts which are of such great significance and importance to the modern clinician, for the book is constructed upon strong anatomic foundations and will appeal primarily to the student of autonomic anatomy and to the surgeon. A relatively current bibliography, following each of the 28 chapters, and the numerous, superb illustrations, many in color, stand as the outstanding features of the book. The chapters are grouped into four major subdivisions which begin with a splendid historical section, followed by a discussion of the principles of autonomic function based primarily upon older anatomic concepts of classification. Of particular
Algorithm of Golgi protein 73 and liver stiffness accurately diagnoses significant fibrosis in chronic HBV infection

Serum Golgi protein 73 (GP73) is a potential biomarker for fibrosis assessment. We aimed to develop an algorithm based on GP73 and liver stiffness (LS) for further improvement of accuracy for significant fibrosis in patients with antiviral‐naïve chronic hepatitis B virus (HBV) infection.
Hepatitis C elimination among people who inject drugs: Challenges and recommendations for action within a health systems framework

The burden of hepatitis C infection is considerable among people who inject drugs (PWID), with an estimated prevalence of 39%, representing an estimated 6.1 million people who have recently injected drugs living with hepatitis C infection. As such, PWID are a priority population for enhancing prevention, testing, linkage to care, treatment and follow‐up care in order to meet World Health Organization (WHO) hepatitis C elimination goals by 2030. There are many barriers to enhancing hepatitis C prevention and care among PWID including poor global coverage of harm reduction services, restrictive drug policies and criminalization of drug use, poor access to health services, low hepatitis C testing, linkage to care and treatment, restrictions for accessing DAA therapy, and the lack of national strategies and government investment to support WHO elimination goals. On 5 September 2017, the International Network of Hepatitis in Substance Users (INHSU) held a roundtable panel of international experts to discuss remaining challenges and future priorities for action from a health systems perspective. The WHO health systems framework comprises six core components: service delivery, health workforce, health information systems, medical procurement, health systems financing, and leadership and governance. Communication has been proposed as a seventh key element which promotes the central role of affected community engagement. This review paper presents recommended strategies for eliminating hepatitis C as a major public health threat among PWID and outlines future priorities for action within a health systems framework.
TAM Split Ergativity, Part I

This article surveys empirical and theoretical work on Tense-Aspect-Mood (‘‘TAM’’) based split ergativity, and offers an account for how it arises. While these splits are typically assumed to represent a unified phenomenon, I demonstrate that non-ergative portions of split systems exhibit different patterns. I argue that these patterns reflect at least two different triggers of split ergativity: (i) non-perfective aspects are more likely to be built on complex auxiliary constructions, and (ii) imperfectivity is associated with demoted objects or lower transitivity. Both causes trigger the same result: in the ‘‘split’’ portions of the grammar the transitive subject is not marked with ergative case because it is not a transitive subject. This structural account of split ergativity allows us to avoid positing variable feature inventories on the same functional head (cf. Ura 2006), and also provides a straight-forward account of the so-called ‘‘counter-universal’’ splits (Gildea and de Castro Alves 2010), which cause problems for purely functionalist accounts (e.g. DeLancey 1981). Furthermore, it is shown that the factors which trigger these splits are not limited to ergative languages, but are present cross-linguistically—they are not visible in nominative-accusative systems because (by definition) there is no visible difference between transitive and intransitive subjects. The prevalence of splits in ergative systems is thus not taken to reflect any deep instability of ergativity.
RURAL HEALTH IN QUEENSLAND: A CHANGING FOCUS

: This paper describes the development of Queensland's rural health policy approach over the past 5 years. The period is marked by significant political, structural and philosophical changes at state and departmental levels. The regionalisation of Queensland's public health services and introduction of strategic management, a commitment to social justice principles and a social view of health, and the acceptance of ‘rurality’ requiring a special focus have been key factors in the rural health policy arena. Queensland's policy formulation process was also influenced by national developments in the emergence of a national rural health strategy. In addition, the recognition that outcomes for rural communities reflect decisions made by a number of agencies has seen the creation of new and influential rural policy co-ordinating bodies with a total Government focus.
Flavobacterium enshiense sp. nov., isolated from soil, and emended descriptions of the genus Flavobacterium and Flavobacterium cauense, Flavobacterium saliperosum and Flavobacterium suncheonense.

A Gram-negative, strictly aerobic, yellow-pigmented rod, designated DK69(T), was isolated from soil collected from the waste liquid treatment facility of Bafeng Pharmaceutical Company in the city of Enshi, Hubei Province, China. Phylogenetic analysis based on 16S rRNA gene sequences placed strain DK69(T) in the genus Flavobacterium of the family Flavobacteriaceae. The highest 16S rRNA gene sequence similarities were found with Flavobacterium cauense R2A-7(T) (96.9 %), Flavobacterium saliperosum AS 1.3801(T) (96.3 %) and Flavobacterium suncheonense GH29-5(T) (95.7 %). The major fatty acids (≥5 %) were iso-C15 : 0, iso-C17 : 1ω9c, C15 : 0, iso-C17 : 0 3-OH and iso-C15 : 0 3-OH. The major polar lipids were phosphatidylethanolamine, one unidentified aminolipid and one unidentified lipid. The major respiratory quinone was menaquinone-6. The genomic DNA G+C content was 34.4 mol%. Strain DK69(T) represents a novel species of the genus Flavobacterium, for which the name Flavobacterium enshiense sp. nov. is proposed. The type strain is DK69(T) ( = CCTCC AB 2011144(T) = KCTC 23775(T)). Emended descriptions of the genus Flavobacterium and Flavobacterium cauense, Flavobacterium saliperosum and Flavobacterium suncheonense are also proposed.
Effect of Listening to Music on Patient Anxiety and Pain Perception during Urodynamic Study: Randomized Controlled Trial

Urodynamic studies (UDS) include assessments of the physics and physiology of the lower urinary tract (LUT). It is an invasive test and patients can feel fear and anxiety, especially at the beginning of the test. The aim of this study was to determine whether listening to music during urodynamic study decreases patient anxiety and pain.
Dietary Intakes of an Elderly Population in Athens, Greece

Abstract Despite a general agreement on the importance of diet on the health status of the elderly, there is very little information about the dietary intakes and eating habits of the Greek elderly. This study assesses the energy and nutrient intakes of 205 healthy elderly individuals in Athens, Greece. The participating subjects, aged 65-92 years, were divided into free living, home bound and institutionalized, according to their status. Results showed that women had lower energy intakes compared to men. Institutionalized individuals had lower intakes of energy and most nutrients, compared to the other two groups. Energy derived from fat was 36.5 to 40%. Vitamin and mineral intakes were adequate for most nutrients. Lower than recommended intakes were found only for vitamin B6 and zinc. A high mean intake of vitamin C and folic acid was found for all three groups.