Miracle-dz/UniFAR-FTUs huggingface dataset:
Surgical options of the breast and clinical outcomes of breast cancer patients after neoadjuvant chemotherapy: A single-center retrospective study

Background Neoadjuvant chemotherapy (NAC) has evolved significantly and has been widely accepted for downstaging disease in early-stage and locally advanced breast cancer patients. Since the optimal surgical intervention for patients receiving NAC remains controversial, we aim to investigate the survival outcome of patients treated with different surgical management. Methods A retrospective, nested case-control study was conducted in patients with invasive breast cancer that underwent NAC at Fudan University Shanghai Cancer Center from January 2010 to June 2019. Based on surgical intervention, patients were divided into mastectomy and breast conservation groups. Patients were matched on age at diagnosis, menopausal status, the year of the surgery, post neoadjuvant therapy pathological tumor (ypT) stage, post neoadjuvant therapy pathological node (ypN) stage, molecular subtypes, and axillary surgery by propensity score matching. Results A total of 2080 patients were enrolled in this study. Among them, 1819 (87.5%) patients were categorized as mastectomy group, and 261 (12.5%) patients were classed as breast conservation group. Over 9-years of research, the proportion of breast conservation steadily increased in patients after NAC. Data showed that younger (P<0.001) and pre-menopausal (P<0.001) patients with normal BMI (P=0.022) were more likely to receive breast conservation. Patients at advanced ypT stage (P<0.001), ypN stage (P<0.001), and clinical TNM stage (P<0.001) were more often to undergo mastectomy, while breast conservation rate was significantly higher in patients with triple-negative tumors (P=0.023). Compared with the mastectomy group, significant benefits in overall survival were observed in patients who received breast conservation (Hazard ratio 0.41, [95% confidence interval: 0.18-0.97]; p=0.049) in the matched cohort. There was no statistical difference between groups related to disease-free survival and locoregional recurrence. Conclusions Tumor biology can significantly impact the surgical decision in patients administrated with NAC. Breast conservation was a safe alternative for mastectomy in the NAC setting without compromising survival outcomes and locoregional control.
The metropolitan production of “urban” sustainability: Exploring industrial regionalism across the Puget Sound

This article engages governance visions for green urbanism and sustainability through the concept of “industrial regionalism”. Bringing together emerging research on the importance of manufacturing to inclusive economies and critiques of “methodological cityism”, we explore the relational production of the iconic “green city” of Seattle. Here we consider how secondary cities, suburbs, and other peripheral spaces get subsumed within the metropolitan production of “urban” sustainability in ways that go unacknowledged and underappreciated. By absorbing tasks of production and social reproduction, such peripheral spaces may enable primate cities like Seattle to claim the mantle of sustainability, highlighting the rain gardens, bike lanes, urban green spaces, and other infrastructures that score high on walkability indices. In contrast, the working-class livelihoods on the periphery are often marginalized from sustainability discourses, if not actively disparaged for their inability to measure up to the green city ideal. This paper aims to offer a corrective by exploring how peripheral spaces are involved in the production of primate city sustainability. Employing the concept of intra-regional relationality, and drawing from census and geospatial data as well as regional planning analyses and reports, we illustrate that “urban” sustainability is produced regionally and relationally. The aim here is to consider how the “industrial region” might gain purchase as an important component of the governance of urban sustainability.
Quantitative collateral score for the prediction of clinical outcomes in stroke patients: Better than visual grading

Objectives To identify preoperative prognostic factors for acute ischemic stroke (AIS) patients receiving mechanical thrombectomy (MT) and compare the performance of quantitative collateral score (qCS) and visual collateral score (vCS) in outcome prediction. Methods Fifty-five patients with AIS receiving MT were retrospectively enrolled. qCS was defined as the percentage of the volume of collaterals of both hemispheres. Based on the dichotomous outcome assessed using a 90-day modified Rankin Scale (mRS), we compared qCS, vCS, age, sex, National Institute of Health stroke scale score, etiological subtype, platelet count, international normalized ratio, glucose levels, and low-density lipoprotein cholesterol (LDL-C) levels between favorable and unfavorable outcome groups. Logistic regression analysis was performed to determine the effect on the clinical outcome. The discriminatory power of qCS, vCS, and their combination with cofounders for determining favorable outcomes was tested with the area under the receiver-operating characteristic curve (AUC). Results vCS, qCS, LDL-C, and age could all predict clinical outcomes. qCS is superior over vCS in predicting favorable outcomes with a relatively higher AUC value (qCS vs. vCS: 0.81 vs. 0.74) and a higher sensitivity rate (qCS vs. vCS: 72.7% vs. 40.9%). The prediction power of qCS + LDL-C + age was best with an AUC value of 0.91, but the accuracy was just increased slightly compared to that of qCS alone. Conclusion Collateral scores, LDL-C and age were independent prognostic predictors for patients with AIS receiving MT; qCS was a better predictor than vCS. Furthermore, qCS + LDL-C + age offers a strong prognostic prediction power and qCS alone was another good choice for predicting clinical outcome.
User‐stakeholders' responsiveness: A necessary input for achieving in e‐governance transformation in developing countries

e‐Government is a social innovation phenomenon in the contemporary times, with extensive promises for social livelihood progress in developing counties. e‐Government has opened up potentials and opportunities for the operationalization of information and communication technologies (ICTs) for human development goals in the socioeconomic fields. e‐Government has unveiled political playgrounds for the citizens such as the Diasporas, who can participate in their home countries political processes through electronic voting for instance. e‐Government is a tool for the realization and strengthening of good governance processes. With such relevance in the background, there is always a gap for contribution in that context of technology and society relationships, through investigation of areas for implementation, improvement, or effective practicing of e‐government. In the implementation of e‐government, Tanzania is said to be evolving through the digital presence–interaction–transaction–transformation stages of e‐government maturity models (eGMMs). We are of the opinion that transformation for e‐government cannot be achieved in the pragmatics of eGMMs framework. We suggest the adoption of information systems project framework (ISPF) to enhance focusing on “user‐stakeholders” as strategic components for e‐governance effectiveness towards transformation, and that the responsiveness of user‐stakeholders at different levels of e‐government operations is potentially important in the phenomenon.
Factors Affecting Adoption and Use of Mobile Banking Services in Zambia Based on TAM Model

The aim of the study was to identify the factors that affect the adoption and use of mobile banking services in Zambia based on the Technology Acceptance Model. Mobile banking a product offered under electronic banking services was the focus of the study. A quantitative research design was used, with a sample size of 384 respondents who held retail savings and current accounts that were eligible for mobile banking services in three commercial banks. A survey questionnaire was used as the primary data collection tool and the data collected was analysed using the IBM SPSS statistics. The results of study were that there is a significant positive relationship between perceived ease of use, perceived usefulness, user attitude, external variables, user intention and system use. The regression results further showed that, the independent variables in the TAM model, perceived ease of use, perceived usefulness, external factors, user attitude and user intention account for 47% of the variance in the factors that determine the use of electronic banking technologies such as mobile banking. The study recommends that commercial banks and the providers of mobile banking services need to improve the perceived ease of use, perceived usefulness, external factors; and promote positive user attitude and user intention. This would result in improved adoption and use of mobile banking services. They should also provide information on how to access and use these services.
A CONCEPTUAL PAPER ON WORKING CAPITAL MANAGEMENT THEORIES

Diverging from the underpinning of prominent decision-making in the corporate finance (e.g. investments, capital structure, dividends and corporate valuation) which possess the nature of long-term time period, working capital management (WCM) which monitoring and controlling the effectiveness of short-term assets and liabilities has deprived of decent attention from top management (PWC, 2017). Likewise, prior empirical findings have attested WCM as one of the most prominent yet least apprehend drivers (Losbichler & Mahmoodi, 2012). The prominent of WCM is evidenced having significant impact irrespective of the firms’ size, sector, industry, country as well as nature of the economy (Bhatia & Srivastava, 2016; Padachi, 2006). On the other hand, Palombini and Nakamura (2012) point out that the lacking of robust and well-adopted theories that are adequately comprehensive in explaining WCM. This paper stipulates essential working capital components (i.e. inventories, accounts receivable & accounts payable) which have been scrutinised to represent the length of cash conversion cycle as well as the level of working capital requirements. The organisation of this study is initiated with the delineation of theories that are pertaining to the management of elements of short-term assets as well as liabilities, following by the depiction of the linkage between theorem and WCM components, in pursuance of the dual objectives i.e. profitability and liquidity.
PENGUATAN HUMAN CAPITAL DALAM PEMBERDAYAAN EKONOMI MASYARAKAT LOKAL DI DISTRIK TANAH MIRING KABUPATEN MERAUKE

Tujuan dari penelitian ini untuk menganalisis penguatan human capital dapat mendukung pemberdayaan ekonomi masyarakat lokal Di Distrik Tanah Miring Kabupaten Merauke. Metode yang digunakan untuk mencapai tujuan adalah dengan melakukan edukasi kepada masyarakat tani dengan berbasiskan pada kelompok usaha tani. Penelitian menggunakan pendekatan kualitatif, sedangkan teknik pengumpulan data terdiri dari studi pustaka dan studi lapangan melalui pengamatan, wawancara. Proses analisis data meliputi reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukan bahwa penguatan human capital bagi masyarakat local di Distrik Tanah Miring masih rendah, hal ini akan berdampak pada peningkatan ekonomi masyarakat local itu sendiri yang secara tidak langsung akan memberikan dampak pada tingkat kesenjangan ekonomi antara masyarakat local dan masyarakat transmigrasi. Pola pelatihan yang diberikan dari berbagai pihak belum berdasarkan analisis kemampuan masyarakat local yang masih terbatas baik dari segi pengetahuan maupun tingkat pemahamannya karena proses pertanian masyarakat local masih bersifat tardisional dan masih bergantung kuat pada alam, dilain pihak pelatihan yang diberikan belum diimbangi dengan pendampingan langsung kepada masyarakat untuk memperaktikan secara langsung kepada masyarakat yang sudah menerima pelatihan, karena masyarakat local akan mudah memahami suatu hal yang diberikan dengan cara memperaktikan secara langsung yang dilakukan secara rutinitas. Kata Kunci: Penguatan human capital masyarakat local; Pemberdayaan ekonomi masyarakat local
DETERMINANTS OF THE INTENTION OF MUZAKKI TO PAY PROFESSIONAL ZAKAT

The objective of this study is to empirically explore the effect of reputation, transparency, accountability of LAZ (Lembaga Amil Zakat or institutions that collect zakat which is a kind of Islamic tithe or alms), the religiosity of muzakki (communities who are obliged to pay zakat), and the trust of muzakki in LAZ on the strength of the intention of muzakki to pay professional zakat through amil (collectors). In addition, this study also attempts to empirically investigate the factors influencing the reputation of LAZ and the trust of muzakki in LAZ. The population of this study is civil servants in Pati District, Central Java, who already have an obligation to pay zakat. The sample of this study is determined by the incidental method and has produced 73 respondents. Data analysis uses the Structural Equation Model with the WarpPLS tool. Research showed empirically that the reputation of LAZ is positively influenced by the transparency and accountability of LAZ. The trust of muzakki in LAZ is influenced by the reputation of LAZ and the religiosity of muzakki. Furthermore, the strength of the intention of muzakki to pay zakat is influenced by the reputation of LAZ, the transparency of LAZ, the religiosity of muzakki, and the trust of muzakki in LAZ. The potential of zakat can be increased by improving LAZ performance (reputation, transparency) and the religiosity of muzakki. ==============================================================================================Determinan Intensi Muzakki dalam Membayar Zakat Penghasilan. Penelitian ini secara empiris bertujuan untuk mengeksplorasi pengaruh reputasi, transparansi, akuntabilitas Lembaga Amil Zakat (LAZ), religiusitas muzakki, dan kepercayaan muzakki pada LAZ terhadap besaran keinginan muzakki untuk membayar zakat penghasilan melalui LAZ. Selain itu, penelitian ini juga bermaksud untuk secara empiris melakukan investigasi terhadap faktor-faktor yang mempengaruhi reputasi LAZ dan kepercayaan muzakki terhadap LAZ. Yang menjadi populasi dalam penelitian ini adalah para pegawai negeri sipil di Kabupaten Pati, Jawa Tengah, yang sudah sampai nishab zakat. Sampel untuk penelitian berjumlah 73 orang yang ditentukan dengan metode insidental sampling. Data lapangan kemudian dianalisis dengan Structural Equation Model dengan WarpPLS tool. Hasil kajian menunjukkan bahwa secara empiris reputasi LAZ secara positif dipengaruhi oleh transparansi dan akuntabilitas LAZ itu sendiri. Sedangkan kepercayaan muzakki terhadap LAZ dipengaruhi oleh reputasi LAZ dan religiusitas muzakki. Selanjutnya, besaran keinginan muzakki untuk membayar zakat dipengaruhi oleh reputasi, transparansi LAZ, religiusitas muzakki, dan kepercayaan muzakki terhadap LAZ. Potensi zakat bisa dimaksimalkan dengan meningkatkan kinerja LAZ (reputasi, transparansi), dan religiusitas muzakki.
The effects of supplementation of probiotics, prebiotics, or synbiotics on patients with non-alcoholic fatty liver disease: A meta-analysis of randomized controlled trials

Background Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease. Research on the efficacy of probiotics, prebiotics, and synbiotics on NAFLD patients continues to be inconsistent. The purpose of this study is to evaluate the effectiveness of these microbial therapies on NAFLD. Methods Eligible randomized-controlled trials reporting the effect of probiotics, prebiotics, or synbiotics in NAFLD were searched in PubMed, Web of Science, Embase, Google scholar, and CNKI databases from 2020 to Jul 2022. The changes in the outcomes were analyzed using standard mean difference (SMD) and 95% confidence intervals (CIs) with a random- or fixed-effects model to examine the effect of microbial therapies. Subgroup analysis, influence and publication bias analysis were also performed. The quality of the eligible studies was evaluated using the Cochrane Risk of Bias Tool. Results Eleven studies met the inclusion criteria involving 741 individuals. Microbial therapies could improve liver steatosis, total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL-c), alanine aminotransferase (ALT), alkaline phosphatase (ALP), glutamyl transpeptidase (GGT), and homeostasis model assessment-insulin resistance (HOMAI-R) (all P < 0.05). But microbial therapies could not ameliorate body mass index (BMI), energy, carbohydrate, fat intake, fasting blood sugar, HbA1c, insulin, high-sensitivity C-reactive protein (hs-CRP), and hepatic fibrosis of patients with NAFLD. Conclusion Probiotics, prebiotics, and synbiotics supplementation can potentially improve liver enzymes, lipid profiles, and liver steatosis in patients with NAFLD.
Antecedents of Adoption of Virtual Reality in Experiencing Destination: A Study on the Indian Consumers

ABSTRACT This study has examined the antecedents of adoption of Virtual Reality (VR) among the Indian tourists using the Technology Acceptance Model (TAM). Perceived enjoyment and perceived immersion have been added to the TAM model as two additional antecedents, and their interrelationships and impacts on tourist's intention to adopt VR were examined. Structural equation modelling was used to analyze the responses obtained from 259 respondents. This study has contributed to the literature by establishing interrelationships among the proposed constructs. Further, this study has advanced the TAM in the context of the adoption of VR by Indian tourists while selecting a tourist place.
Molecular interplays of the Entamoeba histolytica endosomal sorting complexes required for transport during phagocytosis

Entamoeba histolytica, the causative agent of human amoebiasis, exhibits a continuous membrane remodelling to exert its virulence properties. During this dynamic process, the Endosomal Sorting Complexes Required for Transport (ESCRT) machinery is a key player, particularly in phagocytosis, a virulence hallmark of this parasite. In addition to ESCRT, other molecules contribute to membrane remodelling, including the EhADH adhesin, EhRabs, actin, and the lysobisphosphatidic acid (LBPA). The endocytosis of a prey or molecules induces membrane invaginations, resulting in endosome and multivesicular bodies (MVBs) formation for cargo delivery into lysosomes. Alternatively, some proteins are recycled or secreted. Most of these pathways have been broadly characterized in other biological systems, but poorly described in protozoan parasites. Here, we encompass 10 years of ESCRT research in E. histolytica, highlighting the role of the ESCRT-I and ESCRT-III components and the EhADH and EhVps4-ATPase accessory proteins during phagocytosis. In particular, EhADH exhibits a multifunctional role along the endocytic pathway, from cargo recognition to endosome maturation and lysosomal degradation. Interestingly, the interaction of EhADH with EhVps32 seems to shape a concurrent route to the conventional one for MVBs biogenesis, that could optimize their formation. Furthermore, this adhesin is secreted, but its role in this event remains under study. Other components from the endosomal pathway, such as EhVps23 and LBPA, are also secreted. A proteomic approach performed here, using an anti-LBPA antibody, revealed that some proteins related to membrane trafficking, cellular transport, cytoskeleton dynamics, and transcriptional and translational functions are secreted and associated to LBPA. Altogether, the accumulated knowledge around the ESCRT machinery in E. histolytica, points it out as a dynamic platform facilitating the interaction of molecules participating in different cellular events. Seen as an integrated system, ESCRTs lead to a better understanding of E. histolytica phagocytosis.
Modern family planning use among people living with HIV/AIDS: a facility based study in Ethiopia

Introduction Despite increasing efforts to address the reproductive health needs of persons living with Human Immuno-Deficiency Virus (HIV), a high unmet need for contraception exists among HIV+ women in sub-Saharan Africa. Currently, Ethiopia promotes integration of family planning (FP) services in to HIV chronic care. Yet the contraceptive prevalence rate among clients remains low. The objective of the study was to assess the role of socio-cultural factors on modern family planning use among HIV+ clients attending Anti-Retroviral Therapy clinics in Addis Ababa sub-cities. Methods The study involved a facility based cross sectional survey. The ten sub cities were initially categorized/stratified into 5 based on direction (East, West, South, North and Central) and from each category one sub city was randomly selected. The total sample size was proportionally allocated to the selected health facilities according to previous monthly average client load per health center. Participants were selected using simple random sampling technique during their routine visit at the health centers. Data were collected through a semi-structured interviewer administered questionnaire. Both descriptive and inferential statistics were generated and results considered significant at 95% confidence level using STATA version 14.0. Results Six hundred and thirty-six clients participated in the study. Majority of them were age between 30-39 years. Though majority, 607 (95.4%) participants approved the use of modern FP method, current use rate stood at 39%. Condom was the most (14.5%) commonly used single method. The odds of FP use by participants who disclosed their HIV status were almost twice that of their counterparts (AOR= 1.84; 95% CI: 1.14, 2.95). Participants who held discussion with their spouse/partners concerning FP, irrespective of the frequency had an odd of more than four when using FP than their counterparts (AO= 4.35; 95% CI: 2.69, 7.04). Conclusion This study revealed that 6 out of every 10 HIV+ clients are not currently using FP methods. Disclosure of HIV status as well as open discussion with spouse/partner were positively associated with family planning use. These study findings call for comprehensive and client focus FP education and counseling in line with disclosure of HIV status and dialogue with spouse/partner in order to increase uptake and utilization of FP among clients. Partners have a great influence on the use and choice of FP methods, so their views are paramount.