Miracle-dz/UniFAR-FTUs huggingface dataset:
NDT-164579-01Effects of Traditional and Cyber Homophobic Bullying

and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). Neuropsychiatric Disease and Treatment 2018:14 1309–1317 Neuropsychiatric Disease and Treatment Dovepress
New Trends and Issues Proceedings on Humanities and Social Sciences

Implementation of sport in university curricula is an important issue considering its importance in creating a fully developed personality and its impact on participation in sport and physical activity during the entire life. Therefore, At Goce Delcev” University Stip, Macedonia, sport is implemented as obligatory university course, realized in the first academic year at all faculties within the University. Considering the fact that course Sport and recreation is realized as unified curricula at all Faculties, we were interested in possible differences in students preferences toward sport activities and realization of sport and recreation course based on a selected faculty of study – humanities, technical sciences, natural sciences and arts. The research was realized on a sample of 670 respondents, full time students in the first academic year at thirteen faculties at “Goce Delcev” University. Students’ opinions for Sport and recreation were determined using a closed form of questionnaire. Obtained results were processed using basic descriptive statistics parameters and comparative statistics (Chi-square test). The obtained results suggest on differences related to selection of current and preferred activities, number of weekly classes for sport, theoretic lectures. Obtained results suggest the directions and possibilities for future interventions in current course and its design according to the students’ interests and needs.
Early Decompressive Craniectomy after Severe Traumatic Brain Injury

Background: The role of decompressive craniectomy in the management of severe traumatic brain injury is a subject of debate in the present era. Increased intracranial pressure (ICP) can cause brain ischemia and compromised brain oxygen after severe traumatic brain injury (TBI). Decompressive craniectomy (DC) is applied to treat post-traumatic intracranial hypertension (IC H). The purpose of this study is to prove the efficacy of early decompressive craniectomy (DC) in the treatment of elevated ICP and good clinical outcome after severe head injury. Methods: A retrospective study was conducted of 21 patients who underwent cranial decompression after severe head injury. Baseline demographics, neurological examination results, and underlying pathology were reviewed. Clinical outcome was assessed by length of intensive care unit stay, length of hospital stay, and survival at discharge. Control of intracranial hypertension was assessed by intracranial pressure (ICP) monitoring and an ICP therapeutic intensity index. Radiographic outcomes were assessed by comparing preoperative and postoperative CT scans for: 1) postoperative volume of cerebral expansion and brain edema; 2) presence of uncal herniation; 3) intracerebral hemorrhage; 4) Subdural collections, and 5) brain ischemia. The patient's age, six, trauma etiology, GCS and focal neurological deficit at admittance, and associated other injuries were reviewed as well. According to GCS results, the patients were grouped as severe TBI (GCS=3-8), moderate TBI (GCS=9-13) or mild TBI (GCS=14 and 15). Only Severe TBI group are reviewed in this study while other groups are excluded. Results: DC was performed on average 2- 12 hrs after admission. DC was found to immediately reduce ICP about 6-11 mm Hg from 20, 27mmhg to 14-16mmHg). TIL, continued to improve within the postsurgical monitoring period. The duration and severity of CIB were significantly reduced as an effect of DC. The overall mortality rate in the patients was lower than predicted at the time of admission. Conclusion: These results suggest that a DC for increased ICP can reduce the CIB of the brain after severe TBI. We suggest that DC be considered early in a patient's clinical course, particularly when the TIL and ICP are increased. Also large decompressive craniectomy (frontotemproparietal) combined with enlargement of the dura by duraplasty seems to have the most favorable results beside it decrease the risk of several secondary surgical complications. (Omar Abdelhay Eldanasory and Mahmoud Farid B.A. Early Decompressive Craniectomy after Severe Traumatic Brain Injury. Life Sci J 2014;11(9):701-706). (ISSN:1097-8135). http://www.lifesciencesite. com . 106
Exploring reactive access control

As users store and share more digital content at home, effective access control becomes increasingly important. One promising mechanism for helping non-expert users create accurate access policies is reactive policy creation, in which users can update their policy dynamically in response to access requests that cannot otherwise succeed. An earlier study suggested that reactive policy creation may be a good fit for file access control at home. To test this theory, we designed and piloted an experience sampling study in which participants used a simulated reactive access control system for a week. Preliminary results suggest a neutral to positive response to using this kind of system and indicate that reactive policy creation may help meet users' need for dynamic, contextual policy decisions.
Visual Outcomes and Prognostic Factors of Intralenticular Foreign Bodies in a Tertiary Hospital in North China

Purpose The aim of this study is to describe the epidemiological and visual outcomes and to identify the main prognostic factors of intralenticular foreign body (ILFB) injuries. Methods We performed a retrospective review of 21 patients (21 eyes) referred to Hebei Eye Hospital in North China from January 2012 to December 2017, who underwent surgical removal of ILFBs and associated ocular trauma repairs. Data regarding the patient demographics, cause of the injury, nature of the ILFB, clinical features, time interval between the injury and the ILFB removal, time interval between the presentation and the surgery, and the initial and final best-corrected visual acuities (BCVAs) were analyzed, and the main prognostic factors were identified. Results Male adults were most affected by ILFBs (90.5%). The mean age of the patients was 41.5 years (median: 46 years, range: 21 to 60 years). None of the patients were wearing goggles at the time of the injury. The most common ILFB cause was hammering the metal (57.1%), and most of the ILFBs were metallic (71.4%). After medical treatment, the final BCVA was improved significantly (Z = 2.49, P=0.015). There was a significant association between the ILFBs with posterior segment injuries and the final BCVA (χ2 = 10.03, P=0.01). Those factors showing no statistical association with the final BCVA included the age (χ2 = 0.36, P=1.0), gender (χ2 = 0.52, P=1.0), nature of the ILFB (χ2 = 1.11, P=0.54), entrance wound location (χ2 = 2.85, P=0.25), and time interval between the injury and the ILFB removal (χ2 = 1.87, P=0.23). Conclusion This is the first local study to explore the epidemiology of ILFB injuries and to identify the main prognostic factors. There was a significant association between the ILFBs with posterior segment injuries and the final BCVA. Improved public awareness and strengthened education regarding safety are the key approaches to reduce the incidence of eye injuries.
LncRNA LEGLTBC Functions as a ceRNA to Antagonize the Effects of miR-34a on the Downregulation of SIRT1 in Glucolipotoxicity-Induced INS-1 Beta Cell Oxidative Stress and Apoptosis

Type 2 diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose and/or high serum free fatty acids. Chronic hyperlipidemia causes the dysfunction of pancreatic beta cells, which is aggravated in the presence of hyperglycemia (glucolipotoxicity). Long noncoding RNAs (lncRNAs) have been suggested to play key roles in type 1 diabetes mellitus development. However, their roles in glucolipotoxicity-induced beta cell dysfunction are not fully understood. In the present study, we identified the differentially expressed lncRNAs in INS-1 cells exposed to high glucose and palmitate (HG/PA). Among the dysregulated lncRNAs, NONRATT003679.2 (low expression in glucolipotoxicity-treated beta cells (LEGLTBC)) was involved in glucolipotoxicity-evoked rat islet beta cell damage. LEGLTBC functioned as a molecular sponge of miR-34a in INS-1 cells. Additionally, SIRT1 was identified as a target of miR-34a and LEGLTBC promoted SIRT1 expression by sponging miR-34a. The upregulation of LEGLTBC attenuated HG/PA-induced INS-1 cell injury through the promotion of SIRT1-mediated suppression of ROS accumulation and apoptosis. This is the first study to comprehensively identify the lncRNA expression profiling of HG/PA-treated INS-1 beta cells and to demonstrate that LEGLTBC functions as a competing endogenous RNA and regulates miR-34a/SIRT1-mediated oxidative stress and apoptosis in INS-1 cells undergoing glucolipotoxicity.
A Possible Mechanism of Metformin in Improving Insulin Resistance in Diabetic Rat Models

Background Type 2 diabetes has become one of the most common diseases worldwide, causing a serious social burden. As a first-line treatment for diabetes, metformin can effectively improve insulin resistance. It has been reported that 12α-hydroxylated BA (mainly CA) is associated with insulin resistance. The purpose of this study was to analyze the changes in CA and possible signaling mechanisms in diabetic rats after metformin intervention. Methods HepG2 cells were cultured after adding different concentrations of metformin. The cell viability was measured using CCK8 kit, and the expression of FXR, MAFG, and CYP8B1 in cells was detected by WB. The rat models of type 2 diabetes were induced by low-dose streptozotocin by feeding a high-fat diet, and the control rats (CON) were fed on normal food; the diabetic rats (DM) were given a high-fat diet without supplementation with metformin, while the metformin-treated diabetic rats (DM + MET) were given a high-fat diet and supplemented with metformin. Biochemical parameters were detected at the end of the test. Expression levels of FXR, CYP8B1, and MAFG were assessed by WB. Serum CA were measured using an enzyme-linked immunosorbent assay (ELISA). Results In HepG2 cells, metformin dose-dependently enhanced the transcriptional activity of FXR and MAFG and inhibited the expression of CYP8B1. Metformin-treated DM rats showed improved glucose and bile acid metabolism. In addition, significantly increased FXR and MAFG and decreased CYP8B1 were observed in DM + MET rats. At the same time, the CA content of metformin-treated rats was lower than that of diabetic rats. Conclusion Changes in CA synthesis after metformin treatment may be associated with inhibition of CYP8B1. These results may play an important role in improving insulin sensitivity after metformin treatment.
Effect of Fraction 3 of portulaca oleracea on Haematological and Plasma Biochemical Parameters in Male Albino Rats

The effect of oral administration of chromatographic fraction 3 of Portulaca oleracea at doses of 1 mg/kg BW, 2 mg/kg BW and 3 mg/kg BW on haematological and plasma biochemical parameters of albino rats were investigated. The fraction was administered on daily basis for 30 days and blood samples were collected for analyses. Treatment of rats with 3 mg/kg BW of fraction 3 caused significant (p<0.05) decrease in the PCV and RBC values relative to their respective controls, while treatment of rats with 3 mg/kg BW of fraction 3 caused significant (p<0.05) increases in TWBC and platelet counts relative to their respective controls. Treatment of rats with 1 mg/kg BW, 2 mg/kg BW and 3 mg/kg of fraction 3 resulted in significant (p<0.05) increases in the albumin level as well as AST and ALT activities relative to their respective controls. These findings on haematological and plasma biochemical parameters suggest that the possible changes in blood chemistry of the treated rats were due to chromatographic fraction 3 of Portulaca oleracea.
Heart Failure as a Risk Factor for Stroke

According to current estimates, about 1.2 million people in Germany suffer from heart failure (HF). According to data from the German Federal Statistical Office, HF was the second most frequent reason for inpatient treatment in Germany with 432 900 patients treated for HF in 2014 [1]. Chronic HF is also associated with a mortality rate of about 50 % within 5 years [2] and is ranked fourth as the cause of death in the German mortality statistics of 2014 [3]. Besides HF with a reduced ejection fraction (HFrEF, ejection fraction < 40 %, “systolic” heart failure) and HF with preserved ejection fraction (HFpEF; ejection fraction ≥ 50 % “diastolic” heart failure) the current European guidelines introduced the category of heart failure with mid-range ejection fraction (HFmrEF, ejection fraction 40– 49 %) [4]. HF is found in 13–29 % of all patients with acute ischemic stroke and is recognized as the most relevant cardiac cause of ischemic stroke besides atrial fibrillation (AF). This article on the relevance of HF for stroke prevention, acute therapy and prognosis after ischemic stroke is based on a selective literature review and previous publications by the authors [5–7].
Effect of hirsutism on quality of life: a study in Iranian women

Objective To evaluate quality of life (QOL) in hirsute women in southeast Iran. Patients and methods In this cross-sectional study a convenience sample of hirsute females aged at least 18 years attending dermatology clinics of Kerman city, southeast of Iran, in 2005 was assessed. Each person with Ferriman-Gallway (F-G) score ≥8 or one area score equal to 4 was included as a hirsute case. QOL was assessed by self-administrated Dermatology Life Quality Index (DLQI) and SF-36 questioners. Results In this study 96 hirsute females with mean age 27.24 years (range, 18-52 year, SD=6.76) were assessed. The mean F-G score was 13.57±6.83 and the mean DLQI score was 10.95±6.76. Symptoms and feelings had the highest mean score among DLQI sections (2.66±1.51) and limit to work/role due to emotional problems had the lowest mean score in SF-36 sections (52.34± 23.62). Conclusion In our setting, hirsutism had considerable effects on quality of life of the affected women. The most components of the QOL which take effect from the disease are those related to symptoms and feelings.
Impacts of mechanistic changes on HOx formation and recycling

Impacts of mechanistic changes on HOx formation and recycling in the oxidation of isoprene A. T. Archibald, M. C. Cooke, S. R. Utembe, D. E. Shallcross, R. G. Derwent, and M. E. Jenkin School of Chemistry , University of Bristol, Bristol, BS8 1TS, UK rdscientific, Newbury, Berkshire, RG14 6LH, UK Atmospheric Chemistry Services, Okehampton, Devon, EX20 1FB, UK Received: 14 January 2010 – Accepted: 19 February 2010 – Published: 1 March 2010 Correspondence to: M. E. Jenkin (atmos.chem@btinternet.com) Published by Copernicus Publications on behalf of the European Geosciences Union.
Distinct Molecular Phenotype of Sporadic Colorectal Cancers Among Young Patients Based on Multi-omics Analysis.

Paired CRC and mucosa tissues were fresh-frozen during tumor resection for gene expression profiling. 4 Plasma metabolomic profiling (for ColoCare and PRÄVENT participants), antibody microarray proteomics and multiplexed serum-based inflammatory biomarker assays are also previously described and detailed in Supplementary Methods. P-values were adjusted for multiple testing using the Benjamini-Hochberg method.
EV71 infection induces neurodegeneration via activating TLR7 signaling and IL-6 production

As a neurotropic virus, human Enterovirus 71 (EV71) infection causes hand-foot-and-mouth disease (HFMD) and may develop severe neurological disorders in infants. Toll-like receptor 7 (TLR7) acts as an innate immune receptor and is also a death receptor in the central nervous system (CNS). However, the mechanisms underlying the regulation of TLR7-mediated brain pathogenesis upon EV71 infection remain largely elusive. Here we reveal a novel mechanism by which EV71 infects astrocytes in the brain and induces neural pathogenesis via TLR7 and interleukin-6 (IL-6) in C57BL/6 mice and in human astroglioma U251 cells. Upon EV71 infection, wild-type (WT) mice displayed more significant body weight loss, higher clinical scores, and lower survival rates as compared with TLR7-/- mice. In the cerebral cortex of EV71-infected mice, neurofilament integrity was disrupted, and inflammatory cell infiltration and neurodegeneration were induced in WT mice, whereas these were largely absent in TLR7-/- mice. Similarly, IL-6 production, Caspase-3 cleavage, and cell apoptosis were significantly higher in EV71-infected WT mice as compared with TLR7-/- mice. Moreover, EV71 preferentially infected and induced IL-6 in astrocytes of mice brain. In U251 cells, EV71-induced IL-6 production and cell apoptosis were suppressed by shRNA-mediated knockdown of TLR7 (shTLR7). Moreover, in the cerebral cortex of EV71-infected mice, the blockade of IL-6 with anti-IL-6 antibody (IL-6-Ab) restored the body weight loss, attenuated clinical scores, improved survival rates, reduced the disruption of neurofilament integrity, decreased cell apoptotic induction, and lowered levels of Caspase-3 cleavage. Similarly, in EV71-infected U251 cells, IL-6-Ab blocked EV71-induced IL-6 production and cell apoptosis in response to viral infection. Collectively, it’s exhibited TLR7 upregulation, IL-6 induction and astrocytic cell apoptosis in EV71-infected human brain. Taken together, we propose that EV71 infects astrocytes of the cerebral cortex in mice and human and triggers TLR7 signaling and IL-6 release, subsequently inducing neural pathogenesis in the brain.
Zebrafish-Based Discovery of Antiseizure Compounds from the North Sea: Isoquinoline Alkaloids TMC-120A and TMC-120B

There is a high need for the development of new and improved antiseizure drugs (ASDs) to treat epilepsy. Despite the potential of marine natural products (MNPs), the EU marine biodiscovery consortium PharmaSea has made the only effort to date to perform ASD discovery based on large-scale screening of MNPs. To this end, the embryonic zebrafish photomotor response assay and the larval zebrafish pentylenetetrazole (PTZ) model were used to screen MNP extracts for neuroactivity and antiseizure activity, respectively. Here we report the identification of the two known isoquinoline alkaloids TMC-120A and TMC-120B as novel antiseizure compounds, which were isolated by bioactivity-guided purification from the marine-derived fungus Aspergillus insuetus. TMC-120A and TMC-120B were observed to significantly lower PTZ-induced seizures and epileptiform brain activity in the larval zebrafish PTZ seizure model. In addition, their structural analogues TMC-120C, penicisochroman G, and ustusorane B were isolated and also significantly lowered PTZ-induced seizures. Finally, TMC-120A and TMC-120B were investigated in a mouse model of drug-resistant focal seizures. Compound treatment significantly shortened the seizure duration, thereby confirming their antiseizure activity. These data underscore the possibility to translate findings in zebrafish to mice in the field of epilepsy and the potential of the marine environment for ASD discovery.
Hypovitaminosis D in Postherpetic Neuralgia—High Prevalence and Inverse Association with Pain: A Retrospective Study

Hypovitaminosis D (25-hydroxyvitamin D (25(OH)D) <75 nmol/L) is associated with neuropathic pain and varicella-zoster virus (VZV) immunity. A two-part retrospective hospital-based study was conducted. Part I (a case-control study): To investigate the prevalence and risk of hypovitaminosis D in postherpetic neuralgia (PHN) patients compared to those in gender/index-month/age-auto matched controls who underwent health examinations. Patients aged ≥50 years were automatically selected by ICD-9 codes for shingle/PHN. Charts were reviewed. Part II (a cross-sectional study): To determine associations between 25(OH)D, VZV IgG/M, pain and items in the DN4 questionnaire at the first pain clinic visit of patients. Independent predictors of PHN were presented as adjusted odds ratios(AOR) and 95% confidence intervals (CI). Prevalence (73.9%) of hypovitaminosis D in 88 patients was high. In conditional logistic regressions, independent predictors for PHN were hypovitaminosis D (AOR3.12, 95% CI1.73–5.61), malignancy (AOR3.21, 95% CI 1.38–7.48) and Helicobacter pylori-related peptic ulcer disease (AOR3.47, 95% CI 1.71–7.03). 25(OH)D was inversely correlated to spontaneous/brush-evoked pain. Spontaneous pain was positively correlated to VZV IgM. Based on the receiver operator characteristic curve, cutoffs for 25(OH)D to predict spontaneous and brush-evoked pain were 67.0 and 169.0 nmol/L, respectively. A prospective, longitudinal study is needed to elucidate the findings.
Investigating Consumer Attitude and Intention towards Online Food Purchasing in an Emerging Economy: An Extended TAM Approach

Along with the development of the Internet and technology, food retailers have increasingly adopted online channels that enable consumers to buy food products online. This research aims to investigate the factors that influence consumer attitude and intention towards online food purchasing. A research framework was developed by combining the technology acceptance model with website trust, which is an important facilitator of online shopping. Using an online survey, data were obtained from 319 online food shoppers in an Asian emerging economy, i.e., Vietnam. Results from structural equation modeling show that perceived usefulness, perceived ease of use, and website trust are important drivers of attitude towards online food purchasing. Among these drivers, perceived ease of use has the greatest impact on attitude. Additionally, attitude and website trust exert a direct and positive effect on intention towards online food purchasing. Taken together, these findings have important managerial implications for key stakeholders, such as online food retailers, associations, and policy makers. One key implication is that online food sellers must endeavor to make their websites simple to use, easy to navigate, reliable, and secure. Several potential caveats for future research studies are also presented in this paper.
Prevalence and correlates of snoring in medical and nursing students in University Malaysia Sarawak

Using a questionnaire, a snoring study was done in 400 medical and 78 nursing students of University Malaysia Sarawak in 2004 and 2005. The response rates were 72.5% for medical students and 83.3% for nursing students. The habitual snoring percentages for all years, first year and final year medical students were 7.2, 9.9 and 3.6 respectively; and for all years, first year and third year nursing students were 12.3, 13.3 and 8.3. These figures were lower than those found in Hong Kong and Germany, despite similar body mass index (BMI). In the combined group of student, positive correlation with snoring was found in male gender (p=0.011), BMI (p=0.002) and sleep apnoea (p=0.05). For medical students, positive correlation was found in male gender (p<0.0005), weight (p <0.001), height (p <0.001) and sleep apnoea (p<0.001), and for nursing students in BMI (p=0.008) and weight (p=0.033). No significant correlation was found in snoring with Epworth Sleepiness Scale and academic performance.