Miracle-dz/UniFAR-FTUs huggingface dataset:
Serendipitous Treatment of Tularemia in Pregnancy

Abstract We present a young pregnant woman who developed ulceroglandular tularaemia following a bite wound from a kitten. She grew Francisella tularensis from the ulcer. While awaiting bacterial culture results and serology for Bartonella, she was treated with azithromycin, with resolution of fever and axillary tenderness. Treatment recommendations for tularemia are either gentamicin or doxycycline, both of which can be perilous to the fetus. A Centers for Disease Control and Prevention report on the macrolide susceptibility of North American isolates of this organism has been underappreciated. The unanticipated result from this patient may give another potential option for treatment of tularemia in pregnancy.
PDLM: Privacy-Preserving Deep Learning Model on Cloud with Multiple Keys

Deep learning has aroused a lot of attention and has been used successfully in many domains, such as accurate image recognition and medical diagnosis. Generally, the training of models requires large, representative datasets, which may be collected from a large number of users and contain sensitive information (e.g., users’ photos and medical information). The collected data would be stored and computed by service providers (SPs) or delegated to an untrusted cloud. The users can neither control how it will be used, nor realize what will be learned from it, which make the privacy issues prominent and severe. To solve the privacy issues, one of the most popular approaches is to encrypt users’ data with their public keys. However, this technique inevitably leads to another challenge that how to train the model based on multi-key encrypted data. In this paper, we propose a novel privacy-preserving deep learning model, namely PDLM, to apply deep learning over the encrypted data under multiple keys. In PDLM, lots of users contribute their encrypted data to SP to learn a specific model. We adopt an effective privacy-preserving calculation toolkit to achieve the training process based on stochastic gradient descent (SGD) in a privacy-preserving manner. We also prove that our PDLM can achieve users’ privacy preservation and analyze the efficiency of PDLM in theory. Finally, we conduct an experiment to evaluate PDLM over two real-world datasets and empirical results demonstrate that our PDLM can effectively and efficiently train the model in a privacy-preserving way.
Mothers’ Knowledge of Health Caring for Premature Infants after Discharge from Neonatal Intensive Care Units in the Gaza Strip, Palestine

Background: Preterm labor is one of the most public health problems related to neonates admitted to Neonatal Intensive Care Unit (NICU). Poor knowledge among mothers about the care requirements of a preterm neonate is immediate cause for post-discharge medical problems in premature and neonates readmission to NICU. Hence, this study aims to evaluate mothers’ knowledge of caring for premature infants post-discharge from Neonatal Intensive Care Units in the Gaza strip. Methods: A Quantitative-based cross-sectional designs study was used to survey 120 mothers of preterm neonates at the time of preterm neonates discharge by face-to-face interview at Al-Shifa medical complex and Nasser hospital between February and June 2018. Results: The results showed that only about 58.4% of mothers of premature babies had good knowledge about health care needed for premature infants after discharge from NICU. Furthermore, there was no statistically significant difference between the level of knowledge and mother’s sociodemographic characteristics (P-values > 0.05). Conclusion: Mothers’ knowledge of premature infants care was not at the optimal level, which might put the newborns at risk. Therefore, the study emphasizes the necessity of thoughtful exchange of health information between team members and mothers and establishing pre- and post-discharge plans with mothers to start their healthy transition of preterm neonate to home and to ameliorate family concerns.
COMPARISON OF TRIGGER POINT THERAPY AND CONVENTIONAL PHYSICAL THERAPY IN TENSION TYPE HEADACHES

Objective: To compare the effectiveness of trigger point release and conventional physical therapy in tension type headaches. Materials & Methods: Randomized controlled trial (RCT) conducted from 18th February 2017 to 13 July 2018, at Isra institute of Rehabilitation Sciences (IIRS) Isra University, Islamabad Campus, Pakistan. A total of n=31 healthy individuals with tension type headache below the age of 50 years, were selected through non probability convenient sampling technique and randomly divided into conventional physical therapy and trigger point therapy group. The pain and Headache disability index data was compared at baseline and during and after the intervention while quality of life was measured pre and post the sessions. For within the groups changes RM-ANOVA was used and for between the groups differences independent sample t-test was used. Results: The results showed that pain was significantly reduced at the end of intervention in conventional physical therapy group as compare to trigger point therapy group (1.31±0.47 ver. 2.13±0.64, p<0.001). Regarding headache disability index, at the end of intervention trigger point therapy group show better results as compare to conventional physical therapy group (32.75±12.83 ver. 53.27±26.57, p=0.01). While comparing quality of life between the groups, no significant difference was observed after intervention. Conclusion: It was concluded that both conventional physical therapy and trigger point therapy are effective in the management of tension type headache. It decreased pain and disability caused by headache but no effect on quality of life due to shorter duration of study. Keywords: Tension type headache, trigger point therapy, stretching exercises.
Assessment of the Thickness of the Roof of the Glenoid Fossa Using Cone Beam Computed Tomography in Asymptomatic Korean Adult Patients

Received September 3, 2019 Revised September 4, 2019 Accepted September 4, 2019 Purpose: The aim of this study was to assess the thickness of the roof of the glenoid fossa (RGF) in Korean adult population without symptoms of temporomandibular disorder (TMD) using cone-beam computed tomography (CBCT). Methods: CBCT Data from 111 Korean adult patients aged ≥25 years (55 males and 56 females) without signs and symptoms of TMD were analyzed retrospectively in this study. The thickness of the RGF was determined as the perpendicular distance between the ‘glenoid fossa line’ and ‘middle cranial fossa line’ on parasagittal and paracoronal reconstructions, respectively. The thickness of the RGF according to sex and age was analyzed using t-tests (p<0.05). Differences were also examined between the right and left sides, and between the paracoronal and parasagittal sides. Results: The mean thickness of the RGF in all subjects was 0.75±0.39 mm; there was no significant difference in thickness between male (0.78±0.36 mm) and female (0.72±0.30 mm). We found no correlation between age and the mean thickness of the RGF, when age was grouped by decade. However, when subjects were divided into >40 years and ≤40 years age groups, the thickness of the RGF was significantly different between the groups. Conclusions: We found that the thickness of the RGF did not differ by sex, but might be affected by aging. Further studies with larger numbers of subjects are needed to confirm the results of this study.
Subclinical ochronosis features in alkaptonuria: a cross-sectional study

Background Alkaptonuria (AKU) is present from birth, yet clinical effects are considered to appear later in life. Morbidity of AKU, considered irreversible, is secondary to ochronosis. Age of ochronosis onset is not clearly known. Nitisinone profoundly lowers homogentisic acid (HGA), the metabolic defect in AKU. Nitisinone also arrests ochronosis and slows progression of AKU. However, tyrosinaemia post-nitisinone has been associated with corneal keratopathy, rash and cognitive impairment in HT 1. The optimal time to start nitisinone in AKU is unknown. Methods In an open, cross-sectional, single-site study, 32 patients with AKU were to be recruited. The primary outcome was presence of ochronosis in an ear biopsy. Secondary outcomes included analysis of photographs of eyes/ears, serum/urine HGA, markers of tissue damage/inflammation/oxidation, MRI imaging, gait, quality of life and Alkaptonuria Severity Score Index (qAKUSSI). Results Thirty patients, with mean age (SD) 38 (14) years, were recruited. Percentage pigmentation within ear biopsies increased with age. Ear pigmentation was detected in a 20-year-old woman implying ochronosis can start in patients before the age of 20. Gait and qAKUSSI were outside the normal range in all the patients with AKU. Conclusions Ochronosis can be present before age 20 years.
Surgically-oriented anatomical study of mandibular premolars: A CBCT study

Background The knowledge of root canal anatomy and of the anatomical relationship should be considered mandatory when planning surgical endodontics. The aim of the study was to investigate the anatomical features of mandibular premolars, evaluating their relationship with mental nerve. Material and Methods CBCT scans were evaluated recording the number of roots, root canal configuration and the relationship with mental nerve of 100 mandibular premolars. After simulating a resection of 3 mm of the root, the shape and the number of canals, and the distance to the buccal and lingual bone plate and to the mental foramen was evaluated. Results The one root - one canal configuration was the most common configuration. The mental foramen was located at the level of MSPs in 40% cases, and it was between MSP and MFP in 46% of cases. The distance between the apex and the vestibular plate was lower than the distance to the lingual one. Conclusions We found a significant heterogeneity in the anatomy of mandibular premolars. CBCT could be considered important when planning surgical endodontics in this region. Key words:Cone-Beam Computed Tomography, bicuspid, root canal, root canal therapy, apicoectomy, mandibular nerve.
Delay Discounting and Cannabinoid Enzyme Inhibitors

Delay Discounting and Cannabinoid Enzyme Inhibitors Devin Andrew Galdieri Delay discounting is a measure of impulsive choice that is correlated with maladaptive behavior and psychological disorders. Disruptions to serotonin and dopamine pathways can cause changes in delay discounting, as can lesions to the prefrontal cortex and nucleus accumbens. The endocannabinoid system modulates other neurotransmitter systems, including dopamine and serotonin pathways. Cannabinoid receptors type 1 are found in relatively high concentrations in the nucleus accumbens and the prefrontal cortex. These receptors are activated by endogenous cannabinoids, which are synthesized on demand and broken down by catabolic enzymes. The action of these enzymes can be inhibited by a class of drugs known as cannabinoid enzyme inhibitors, which ultimately produce higher levels of endogenous cannabinoids by preventing their catabolic degradation. The present study examined effects of two cannabinoid enzyme inhibitors, URB597 and JZL195, on delay discounting in rats. Delay discounting was measured at baseline and after drug administration. Area under the curve and indifference points were not affected by any dose of either drug, but 7.5 mg/kg of JZL195 decreased percent larger-reinforcer choice at the lowest delay value and increased it at the highest delay value. URB597 increase percent larger-reinforcer choice only at one intermediate delay value. JZL195 increased response latencies at the 7.5 mg/kg dose. No systematic, dose-dependent effect of either drug on measures of delay discounting was observed.
Effects of functional appliance treatment on pharyngeal airway passage dimensions in Class II malocclusion subjects with retrognathic mandibles: A systematic review

The objective of this study was to assess the pharyngeal airway passage (PAP) dimension changes following functional appliance treatment in Class II malocclusion subjects with retrognathic mandibles.Two authors independently searched various electronic databases such as PubMed, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Scopus, NCBI, and Google Scholar for the available literature within the period from January 1, 2001, to December 31, 2018. On the basis of population, intervention, comparison, and outcome, “changes in PAP dimensions following functional appliance therapy in skeletal Class II malocclusion subjects associated with mandibular retrusion” was considered as search question of the study. After the selection and removal of duplicate articles, assessment for risk of bias was calculated and the data from the included articles were extracted by two authors independently.From six databases and additional hand searching, a total of 5784 articles were extracted. Of 5784 articles, 3754 articles were screened after removal of 2030 duplicates. After going through the title and abstract, 3197 articles were excluded and 40 articles were assessed for full text. From these 40 articles, eight articles fulfilled our inclusion and exclusion criteria for the qualitative synthesis review.The correction of mandibular deficiency by functional appliances has minimum effect on the nasopharynx. Functional appliance treatment has a significant effect on the improvement of the oropharyngeal airway. Changes of hypopharyngeal airway passage need to be studied further among Class II malocclusion subjects with retrognathic mandibles.
Comparative Analysis of Parathyroid Functions among Sub-total Thyroidectomy Patients after Ligation of Inferior Thryoid Artery

Background: Thyroid surgery commonly in developing countries. Hyperparathyroidism is major issue after surgery. The objective of study is to compare the occurrence of hyperparathyroidism after sub-total thyroidectomy with truncal ligation versus non-ligation of inferior thyroid artery. Methods: Study design was randomized clinical trial. Study was conducted in public sector hospital. Surgical patients who were admitted to hospital for thyroid surgery. Participants were divided into two groups through random allocation, thyroid surgery with and without the ligation of inferior thyroid artery Thyroid surgery for group A with ligation and group B without ligation of Original Research Article Iqbal et al.; AJRS, 2(1): 1-8, 2019; Article no.AJRS. 50466 2 inferior thyroid artery. Serum PTH levels were measured on 3rd post-operative day. The group A and B were compared for level of for the frequency of transient hyperparathyroidism. Results: Mean age in group A was 40.83 yrs (SD = 9.9) and in group B it was 41.34 yrs (SD=8.73). Transient hyperparathyroidism was observed in 6.10% of patients in group A and 7.32% patients in group B and this difference was found to be statistically significant (p=0.02). Conclusion: Result showed that ligation of artery decreased the risk of transient hyperparathyroidism after sub-total thyroidectomy.
A New Floating Memristor Based on CBTA with Grounded Capacitors

This paper presents a new floating memristor emulator (FME) consisting of only a single current backward transconductance amplifier (CBTA) as the active element and two grounded capacitors. The proposed FME-based on CBTA enjoys some advantages that include minimum active and passive elements without using an analog multiplier circuit and grounded passive elements which are attractive for the integrated circuit. In addition, excluding the DC power supply voltage, it does not use bias voltage and/or bias current. The designed memristor circuit provides incremental and decremental characteristics without changing circuit topology or using a switching mechanism and it is implemented with a minimum of circuit elements. All simulation results for the memristor emulator were obtained as expected when compared with fabricated memristors.
Portage de bactéries multirésistantes en structures d'accueil pour personnes âgées : évaluation d'une politique de dépistage cible en fonction des facteurs de risque

A l’heure actuelle, la resistance des bacteries aux antibiotiques est un probleme majeur deSante Publique. Malgre la lutte contre les BMR et les infections nosocomiales qui s’organiseen France et les recommandations officielles en matiere d’hygiene hospitaliere, la situationdans les etablissements d’accueil pour personnes âgees reste preoccupante. En effet lapopulation est fragile et la transmission des germes y est frequente. Pourtant aucunerecommandation ne prevoit le depistage systematique des residents porteurs de BMR, etdonc potentiellement a risque de transmission, a leur arrivee dans la structure. Le cout et lacharge de travail qu’occasionnerait un tel depistage est egalement un frein a sa realisationpour de nombreux etablissements.Ce travail a pour objectif d’identifier les facteurs de risque de portage de BMR afin derestreindre la population a depister lors des admissions en EHPAD.Des prelevements bacteriologiques de diagnostic ou de depistage ont ete realises chez 193residents d’EHPAD du Lunevillois entre 2012 et 2014. Les donnees administratives,cliniques et microbiologiques ont ete recueillies pour chacun des residents. Au total, quatrefacteurs de risque sont apparus significativement associes au portage de BMR. Il s’agit dusondage urinaire, des infections urinaires recidivantes, d’une antibiotherapie anterieure ainsique des antecedents de portage ou de colonisation par BMR.Malgre des resultats encourageants, notre etude manque de sensibilite et ne permet pas demettre au point un depistage cible applicable en l’etat dans les EHPAD.
PHARMACOEPIDEMIOLOGY AND PRESCRIPTION Purchases of medical therapy recommended for coronary artery disease before and after elective revascularisation

Aims We studied the purchases of medical therapy recommended for coronary artery disease patients before and after elective revascularisation (percutaneous coronary intervention (PCI) or coronary bypass grafting (CABG)). Methods All patients who underwent an elective PCI (N = 1557) or CABG (N = 1768) at the Heart Center, Kuopio University hospital between 2007 and 2014 were included. Data were collected from the hospital’s coronary register and national registers, and obtained for 3 years before and 1 year after the revascularisation. Results Altogether 85.2% of PCI patients and 88.1% of CABG patients had purchased lipid-modifying agents before the procedure, and 94.9% and 96.8% during the post-procedure follow-up year, respectively. Betablocking agents were purchased by 84.9% of PCI patients before and by 87.9% after the procedure and by 86.3% of CABG patients before and 97.1% after the operation. Of PCI patients, 64.3% had purchased organic long-acting nitrates before the procedure and 54.4% also after the procedure. Among CABG patients, the purchase of organic long-acting nitrates fell from 59.7% before to 10.1% after the operation. The use of ADP receptor blocking agents increased in PCI patients (26.3 to 83.9%) and the use of warfarin in CABG patients (9.4 to 21.3%). Medication purchases were more common among those who had greater use of hospital services before and after the procedures. Conclusions In both PCI and CABG patients, the use of medical therapy before and after revascularisation procedure complied with current guidelines. Purchases of long-acting nitrates were common in the PCI group even after the procedure.
Determination of Electroacupuncture Effects on circRNAs in Plasma Exosomes in Diabetic Mice: An RNA-Sequencing Approach

circRNAs are involved in diabetes mellitus pathogenesis. Electroacupuncture (EA) is an effective therapeutic strategy for diabetes mellitus. However, whether the mechanism of action of EA on diabetes mellitus is related to altered circRNAs is unclear. The aim of this study was to reveal the effect of EA on circRNA expression in plasma exosomes and the underlying signaling pathway in mice with type 2 diabetes mellitus (T2DM). In total, 10 mice were randomly categorized into a normal group and 20 mice were used for the T2DM model preparation and randomly divided into the model and model + EA groups. Mice in the model + EA group were administered EA treatment. Changes in the fasting blood glucose (FBG) level and islet structure were evaluated. Plasma exosomes were subjected to RNA sequencing, and then bioinformatics analysis and real-time quantitative PCR (qPCR) verification were performed. EA treatment reduced the FBG level, preserved the islet structure, and reduced the islet β cell apoptotic rate in T2DM mice. After EA treatment, 165 differentially expressed circRNAs were found. GO and KEGG analyses revealed that thyroid hormone signaling was actively regulated by EA. circRNA/miRNA interaction analysis revealed mmu-mir-7092-3p to be closely associated with circINPP4B, suggesting that the phosphatidylinositol signaling pathway may be affected by EA. qPCR confirmed that 12 circRNAs had significant differences. These findings suggested that EA intervention can significantly protect islet function and improve the FBG level in T2DM, possibly via regulation of thyroid hormone and phosphatidylinositol signaling.
Prevalence and presentation of hyperdontia in a non-syndromic, mixed Nigerian population

Background Although there have been studies on the prevalence and pattern of hyperdontia in sub-Saharan African subjects with similar cultural backgrounds, based on our search, none have been able to consider these epidemiological parameters in a multiethnic black population, which is expected to add substantial knowledge to what is available. Material and Methods This is a retrospective study on the panoramic radiographs of subjects who presented at two dental centres in Abuja, Nigeria between June 2013 and June 2018. Radiographic interpretations were carried out by three independent observers, trained on computer assisted radiographic image interpretation. Data were collected and analyzed using Statistical package for the Social sciences (SPSS) version 22 (IBM Corp, Armonk, USA). Results One thousand eight hundred and thirty seven (1837) panoramic radiographs were studied. Subject comprised males and females between ages 12 – 95 years with an average of 35.0 years. The prevalence of unilateral hyperdontia was 1.47% while an occurrence rate of 0.27 was observed for bilateral and multiple hyperdontia. For maxillary hyperdontia, a prevalence of 1.09% was recorded which was significantly more common than the mandibular type (0.65). Of note is that all the supernumerary teeth types were commonly observed in the maxilla except the parapremolar type, with a mandibular occurrence rate of 76.9%. Conclusions From this study, we can conclude that the prevalence of hyperdontia (across different black ethnicities) is low. Although, follicular epithelium around the tooth and root resorption of the enlargement around the adjacent teeth was observed, most were asymptomatic (87.0%) and required no intervention. Key words:Hyperdontia, panoramic radiographs, Sub-Saharan Africa, supernumerary teeth.