Miracle-dz/UniFAR-FTUs huggingface dataset:
Molecular and Phylogenetic Analyses of the Complete MADS-Box Transcription Factor Family in Arabidopsis Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.011544.

MADS-box transcription factors are key regulators of several plant development processes. Analysis of the complete Arabidopsis genome sequence revealed 107 genes encoding MADS-box proteins, of which 84% are of unknown function. Here, we provide a complete overview of this family, describing the gene structure, gene expression, genome localization, protein motif organization, and phylogenetic relationship of each member. We have divided this transcription factor family into five groups (named MIKC, Mα, Mβ, Mγ, and Mδ) based on the phylogenetic relationships of the conserved MADS-box domain. This study provides a solid base for functional genomics studies into this important family of plant regulatory genes, including the poorly characterized group of M-type MADS-box proteins. MADS-box genes also constitute an excellent system with which to study the evolution of complex gene families in higher plants.
Analysis of Tractor-Related Deaths

ABSTRACT The aim of the study was to evaluate the properties of tractor-related death cases and discuss the precautions in order to prevent such events. For this aim, reports made between 2006 and 2009 by the First Specialty Board of Council of Forensic Medicine (FSBCFM), Turkey, were evaluated retrospectively. Forty-one tractor-related death cases were included in this study. Thirty-five (85.4%) of the cases were male. The mean age was 42.52 ± 25.1 (with a range between 1 and 84 years old). The average time interval between the incident and death was 13.76 ± 33.53 days (range: 0–176 days) and 20 (48.8%) cases died on the incident spot or during transportation to the hospital. Among the cases, 34.1% (n = 14) were drivers, whereas 39.0% (n = 16) were passengers and the remaining were pedestrians (26.9%, n = 11). The accident was caused by the tractor rolling over in 34.1%, the victim being run over in 22.0%, and the victim falling from the tractor or trailer in 22.0% of the cases. Most of the events (56.1%) occurred on the road. In conclusion, tractors must not be used as a transportation vehicle for passengers. Periodic training of drivers can be useful for reducing tractor-related accidents.
The anti-motion sickness mechanism of ginger. A comparative study with placebo and dimenhydrinate.

A controlled, double-blind study was carried out to determine whether nystagmus response to optokinetic or vestibular stimuli might be altered by some agent contained in powdered ginger root (Zingiber officinale). For comparative purposes, the test subjects were examined after medication with ginger root, placebo and with dimenhydrinate. Eye movements were recorded using standard ENG equipment and evaluation was performed by automatic nystagmus analysis. It could be demonstrated that the effect of ginger root did not differ from that found at baseline, or with placebo, i.e. it had no influence on the experimentally induced nystagmus. Dimenhydrinate, on the other hand, was found to cause a reduction in the nystagmus response to caloric, rotatory and optokinetic stimuli. From the present study it can be concluded that neither the vestibular nor the oculomotor system, both of which are of decisive importance in the occurrence of motion sickness, are influenced by ginger. A CNS mechanism, which is characteristic of the conventional anti-motion sickness drugs, can thus be excluded as regards ginger root. It is more likely that any reduction of motion-sickness symptoms derives from the influence of the ginger root agents on the gastric system.
Consumer adoption of technological innovations: Effects of psychological and functional barriers in a lack of content versus a presence of content situation

Purpose – This study seeks to investigate barriers in the consumer adoption process of technological innovations under different contingencies. The paper aims to focus on barriers impeding adoption of technologies characterized by high incompatibility and high uncertainty – i.e. a “lack of content” (LoC) situation – versus technologies characterized by low incompatibility and low uncertainty – i.e. a “presence of content” (PoC) situation.Design/methodology/approach – Based on a literature study, the paper develops hypotheses that distinguish the diverging effects of both psychological and functional barriers on consumer adoption in different situations (LoC versus PoC). Data were collected by means of a survey, resulting in an effective sample of 229 respondents.Findings – In the case of LoC, the value, risk (financial and performance) and image barrier are negatively related to adoption intention, where the latter barrier is significantly stronger for the LoC situation than for the PoC situation. For PoC.
Evidence of a Generalized Defect of Acinar Cell Function in Shwachman-Diamond Syndrome

Background: Because the acinar cells of the exocrine pancreas in patients with Shwachman-Diamond syndrome (SDS) are severely depleted, we hypothesized that a similar deficiency may be present in acinar cells of the parotid gland. Patients and Methods: We determined serum pancreatic isoamylase and parotid amylase activities in 16 patients with SDS, 13 healthy controls, and 13 disease controls (cystic fibrosis or fibrosing pancreatitis). Parotid amylase and electrolyte concentrations were measured in stimulated parotid gland secretions. Starch digestion was assessed by breath hydrogen testing in patients with SDS (with and without enzyme supplements) and healthy controls. Results: Serum pancreatic and parotid isoamylase values were lower in the patients with SDS than in the healthy controls (P < 0.0001 and P = 0.0002, respectively). Serum pancreatic isoamylase, but not parotid isoamylase, was significantly lower in the disease controls than in the healthy controls (P < 0.0001 and P = 0.17, respectively). Secreted parotid gland amylase concentration (units per milligram of protein) in patients with SDS was lower than that in the healthy controls (P = 0.04), whereas the disease controls were comparable to the healthy subjects (P = 0.09). Secreted parotid chloride concentration was inversely correlated with amylase concentration in the patients with SDS (P = 0.01), but no correlation was seen in the healthy controls or disease controls. When patients with SDS ingested starch without enzyme supplementation, their breath hydrogen excretion was significantly higher than that in the healthy controls (P = 0.009). Following starch ingestion with enzymes, breath hydrogen in the patients with SDS was lower (P < 0.05) than with no enzyme treatment, and no different from controls (P = 0.37). Conclusions: Mutations in the SBDS gene cause a generalized functional abnormality of exocrine acinar cells.
A Horizon Decomposition Approach for the Capacitated Lot-Sizing Problem with Setup Times

We introduce horizon decomposition in the context of Dantzig-Wolfe decomposition, and apply it to the capacitated lot-sizing problem with setup times. We partition the problem horizon in contiguous overlapping intervals and create subproblems identical to the original problem, but of smaller size. The user has the flexibility to regulate the size of the master problem and the subproblem via two scalar parameters. We investigate empirically which parameter configurations are efficient, and assess their robustness at different problem classes. Our branch-and-price algorithm outperforms state-of-the-art branch-and-cut solvers when tested to a new data set of challenging instances that we generated. Our methodology can be generalized to mathematical programs with a generic constraint structure.
Relationship Between Sick Building Syndrome With Headache and Drowsiness

Based on previous researches and current research indoor contaminations in most of the time were more than outdoor contaminations. In according to, most of our times have been spent in indoor environments (85-90%), therefore, it is necessary to investigate indoor environments. Symptoms of sick building syndrome are Headache, dizziness, drowsiness. Unknown reasons of disease above mentioned and improvement and Fixing problems have emerged in people after moving from these buildings. In this research, we investigated basic symptoms of syndrome in illnesses of sick buildings. We designed a questionnaire and asked from male of dormitory residence. Questions of the questionnaire were more about known symptoms of buildings (Shortness of breath, inflammation, swelling and burning eyes, runny nose, malaise and fatigue, drowsiness, headache). Results of research indicated that lack of ventilation system, noises, contaminated materials, cars smoke, noses of crowded streets and high humidity are that most important reasons of sick building syndrome respectively.
Clinicopathological Study of Malignant Eyelid Tumours

A retrospective clinicopathological study of malignant eyelid tumors to study various demographic factors, clinical patterns and histopathological variants. Material and methods: Cases presenting to the department of Oculoplastics and Orbital Diseases was done at Sarojini Devi eye hospital, Hyderabad were studied over a period of three years. We analysed and followed 85 histologically proven cases of malignant eye lid tumours during this period. Benign lesions were excluded from the study. In results Females were more commonly affected and people in fifth and seventh decades of life were predominantly affected. Sebaceous cell carcinoma (SbCC) was the commonest tumour accounting for 67.05%, Basal Cell Carcinoma (BCC) for 27.05% and squamous cell carcinoma of lid occurred least frequently. Most of the cases were successfully treated surgically (82 out of 85) by a margin clearance of 4-6mm.The significance of these observations is discussed.
Postnatal Emotional Disorders in Nigerian Women

One hundred and sixty-two women were evaluated for psychiatric morbidity in the second trimester of pregnancy and also six to eight weeks postnatally. A sizeable proportion of the women also had a second prenatal assessment in their third trimester and in the lying-in ward shortly after giving birth. Assessments were conducted with the 28-item GHQ. This was initially validated using a subsample of 106 women, taken from the original group, who were interviewed with the PAS. Thirty per cent of the women were ‘cases' at the first prenatal assessment, while only 14% were ‘cases' six to eight weeks postnatally. Thus, even though there was an overlap between prenatal and postnatal morbidity, there was also substantial difference between the groups that were symptomatic at both periods. This observation was reinforced by the low correlation between the mean GHQ scores at both periods. Both prenatal and postnatal morbidities were associated with recent adverse life events, with the latter more likely to be associated with marital and family events. This observation is in support of the view that neurotic problems, prenatally or postnatally, are caused mainly by psychosocial factors.
Leptin effects on pancreatic beta-cell gene expression and function.

The hormone leptin is secreted from white adipocytes, and serum levels of leptin correlate with adipose tissue mass. Leptin was first described to act on the satiety center in the hypothalamus through specific receptors (leptin receptor [ObR]) to restrict food intake and enhance energy expenditure. Important peripheral actions of leptin involve inhibition of insulin biosynthesis and secretion in pancreatic beta-cells. In turn, insulin stimulates leptin secretion from adipose tissue, establishing a hormonal regulatory feedback loop-the so-called "adipo-insular axis. " Multiple signal transduction pathways are involved in leptin signaling in pancreatic beta-cells. We have identified the proinsulin gene and protein phosphatase 1 gene as leptin repressed genes and the gene for the suppressor of cytokine signaling 3 protein as a leptin-induced gene in pancreatic beta-cells. The molecular effects of leptin culminate to restrict insulin secretion and biosynthesis to adapt glucose homeostasis to the amount of body fat. In most overweight individuals, however, physiological regulation of body weight by leptin seems to be disturbed, representing "leptin resistance. " This leptin resistance at the level of the pancreatic beta-cell may contribute to dysregulation of the adipo-insular axis and promote the development of hyperinsulinemia and manifest type 2 diabetes in overweight patients.
A study of localization in the corticospinal tracts of monkey and rat

Conflicting views and minimal amounts of evidence have been presented for and against localization within the corticospinal tract at levels from internal capsule to spinal cord. A survey of the literature reveals that small circumscribed lesions of the motor areas and adequate Marchi studies at all levels of the nervous system have not been made in any form with the partial exceptions of monkey (Mellus, 1899) and rat (Woodburne, ’39). No photographs of the Marchi preparations of these studies were published. Clinicians have long held to the belief that some type of localization exists in the lateral cortico-spinal tract of man. This belief has varied from the very specific segmental arrangement diagrammed by Foerster (’36) to the cautious statement of Elsberg ( ’41) covering the arrangement in the cord: “There is some probability, although the evidence is by no means conclusive, that in the pyramidal pathways the fibers which supply the muscles of the limbs have a lamellated arrangement the fibers which supply muscles at a higher level lying more mesial than those supplying muscles a t a lower level. ”
Double-blind comparison between zofenopril and lisinopril in patients with acute myocardial infarction: results of the Survival of Myocardial Infarction Long-term Evaluation-2 (SMILE-2) study.

BACKGROUND Angiotensin-converting enzyme (ACE) inhibitors have been reported to be effective in placebo-controlled trials in various subsets of patients with acute myocardial infarction (MI). However, no direct comparisons have been performed between different ACE inhibitors in the same patient population. METHODS This phase III, double-blind, parallel-group, multicenter study compared the safety and efficacy of zofenopril and lisinopril in 1024 thrombolyzed patients with acute MI. Patients, aged 18 to 75 years, were randomized to receive oral zofenopril (30-60 mg/day) or lisinopril (5-10 mg/day), starting within 12 hours of completion of thrombolytic therapy and continuing for 42 days. The primary study end point was the incidence of severe hypotension (systolic blood pressure <90 mm Hg), either cumulative or drug-related. Secondary end points included additional safety and efficacy parameters. RESULTS The overall incidence of severe hypotension was slightly 5 more reduced with zofenopril (10.9%) than with lisinopril (11.7%, P =.38). The incidence of drug-related severe hypotension was slightly but significantly lower with zofenopril than with lisinopril (6.7 vs 9.8%, 2-tailed P =.048). The 6-week mortality rate was 3.2% in the zofenopril group and 4.0% in the lisinopril group (P =.38), and no significant differences were observed in the incidence of major cardiovascular complications or any safety variables between the 2 ACE inhibitors. CONCLUSIONS The SMILE-2 study demonstrates that both zofenopril and lisinopril are safe and associated with a rather low rate of severe hypotension when given in accordance with a dose-titrated scheme to thrombolyzed patients with acute MI. These findings could have a positive clinical impact and increase the proportion of patients with acute MI who can be safely treated with ACE inhibitors.
An Empirical Validation of Fama and French Three-Factor Model (1992, A) On Some US Indices

The study of mean returns of American stocks showed a poor β coefficient of the Sharpe (1964) and Lintner (1965) capital asset pricing model or the consumption coefficient of Breeden (1979); Reinganum (1981) and Breeden et al. (1989) international consumption-oriented capital asset pricing model. In the same line of thinking, capital asset pricing theory is efficient in explaining stocks mean returns. The empirically determined variables include size (ME: stock price multiplied by stocks number), leverage effect, equity divided by price (E⁄P) and the book-to-market ratio (ratio between stock book value and its market value). Banz (1981); Bhandari (1988); Basu (1983) and Rosenberg et al. (1985) have empirically determining these variables. Using the same method of Fama and French (1992a) we studied the joint roles of market β, size, E⁄P, leverage effect and book-to-market ratio in mean returns. They found that using alone or combined with other variables, β (the regression slope of stock return on market return) poorly explains mean returns. Combining size and market-to-book ratio, the two variables seem to absorb the apparent roles of leverage effect and the E⁄P ratio in explaining mean returns. The main result is that the two empirically determined variables (size and book-to-market) explain well mean returns on the ADI, DJI, TDI and DJU during the 2000-2010 period.
Efficacy of Low‐Level Laser Therapy for Chronic Cutaneous Ulceration in Humans: A Review and Discussion

Chronic wounds, particularly venous ulcerations, are notoriously difficult to heal. Because current therapies are variable in their ability to induce complete healing, there remains a need to develop adjunctive treatments that can improve or accelerate the healing process. The use of low-energy lasers to stimulate wound healing has been pursued over many decades in studies of varying quality. This form of treatment has had high appeal due to its novelty, relative ease, and low morbidity profile. The authors reviewed the available published literature on low-level laser technology in an attempt to provide cumulative insight on the effect of this treatment for wound healing.
Phosphodiesterases coordinate cAMP propagation induced by two stimulatory G protein-coupled receptors in hearts

Inflammation is a significant player in the progression of heart failure and has detrimental effects on cardiac function. Prostaglandin (PG)E2, a major proinflammatory prostanoid in the cardiovascular system, is a potent stimulus in inducing intracellular cAMP but minimally affects cardiac contractile function. Here, we show that the PGE2 stimulation attenuates the adrenergic-induced cardiac contractile response in animal hearts. Stimulation with PGE2 leads to stimulatory G protein (Gs)-dependent production of cAMP. However, the induced cAMP is spatially restricted because of its degradation by phosphodiesterase (PDE)4 and cannot access the intracellular sarcoplasmic reticulum (SR) for increasing calcium signaling and myocyte contraction. Moreover, pretreatment with PGE2 significantly inhibits PKA activities at the SR induced by a β-adrenergic agonist, isoproterenol, and subsequently blocks isoproterenol-induced PKA phosphorylation of phospholamban and contractile responses in myocytes. Further analysis reveals that the PGE2-induced cAMP/PKA is sufficient to phosphorylate and activate PDE4D isoforms, which, in turn, spatially inhibits the diffusion of adrenergic-induced cAMP from the plasma membrane to the SR. Inhibition of PDE4 rescues the adrenergic-induced increase in cAMP/PKA activities at the SR, PKA phosphorylation of phospholamban, and contractile responses in PGE2-pretreated myocytes. Thus, this offers an example that one Gs-coupled receptor is able to inhibit the intracellular signaling transduction initiated by another Gs-coupled receptor via controlling the diffusion of cAMP, presenting a paradigm for G protein-coupled receptor (GPCR) signal transduction. It also provides a mechanism for the integration of signaling initiated by different neurohormonal stimuli, as well as long-term effects of chronically circulating proinflammatory factors in myocardium.
The Termination of Joint Ventures

We analyze different modes of terminating international joint ventures, namely closure and acquisition. We find that the antecedents of the joint venture and the contractual arrangements made at its creation affect the likelihood of the venture being terminated by acquisition and the identity of the partner that makes the acquisition. In contrast, the initial decisions regarding asset specificity and the size of the venture affect the likelihood of closure, but not that of acquisition. We use a very flexible statistical methodology that allows accommodating a variety of time patterns, and even the possibility that some joint ventures never confront the chances of terminating under each of the termination modes. We find that the chances of terminating a joint venture first decrease and then increase over time, in particular when the joint venture is terminated by dissolution of the firm or by acquisition by the foreign partner.
Effect of slaughter weight on the carcass value of young crossbred ('Polish Holstein Friesian' × 'Limousin') steers and bulls

Apart from others factors, carcass quality is determined by the animal’s age and body weight (BW) at the end of the fattening period. The aim of this study was to determine the optimum finishing weight of young crossbred ‘Polish Holstein Friesian’ (PHF) × ‘Limousin’ (LIM) steers and bulls, based on their slaughter value. The experimental materials comprised 60 animals, including 30 bulls and 30 steers, fed farm-made feeds. At 2 or 3 wk of age, one half of calves were castrated. Bloodless castration was carried out using a rubber elastrator. Calves were reared under a conventional system, and were fattened semi-intensively. Daily gains ranged from 800 to 950 g. Calves were fattened to 450, 500, 550, or 600 kg BW. Carcass value was estimated after slaughter. Fatty acid profile was determined by gas chromatography in fat extracted from samples of muscle longissimus dorsi (MLD). Bulls, compared with steers, were characterized by a higher slaughter value, including a higher carcass dressing percentage by 1.07-2.60%, higher carcass conformation, and lower carcass fatness. In steers, an increase in live BW was accompanied by a considerable increase in fat content (higher than bulls), as confirmed by a significant (p ≤ 0.01) interaction. The intramuscular fat of bulls was characterized by higher concentrations of fatty acids delivering health benefits, and a more desirable polyunsaturated fatty acids/saturated fatty acids (PUFA/SFA) ratio. Fat from bulls contained higher levels of PUFAs by 2.34 g 100 g -1 on average. Semi-intensive fattening of PHF × LIM bulls to slaughter weight of 600 kg BW is recommended due to an increase in carcass value. Steers should be fattened to slaughter weight of 500-550 kg BW to prevent excessive fat deposition.
Relationship Between Intraocular Pressure and Obesity in Children

PurposeTo establish the relationship between intraocular pressure (IOP) and obesity in children. MethodsSeventy-two obese children (body mass index in the 95th percentile or greater) were compared with 72 age-matched and sex-matched controls (body mass index <95th percentile). Both groups underwent Goldmann applanation tonometry (3 times), blood pressure measurement (3 times), and Hertel exophthalmometry. Paired and unpaired t tests and the Cochran-Mantel-Haenzel statistics were used for statistical analysis. ResultsThe mean IOP between the obese children and controls were significantly different (P<0.0001), even after adjusting for systolic and diastolic blood pressure (P<0.001). Diurnal variation of IOP was higher in obese children (P<0.001). Obese children had higher Hertel values (P<0.001). Sex did not significantly effect IOP in either group (P>0.05). ConclusionsIn addition to its indirect effect on IOP via blood pressure change, obesity is also an independent risk factor for increased IOP.