Miracle-dz/UniFAR-FTUs huggingface dataset:
Lung Injury after In Vivo Reperfusion: Outcome at 27 Hours after Reperfusion

Background:Although short-term findings after lung reperfusion have been extensively reported, in vivo animal studies have not described outcome beyond the immediate time period. Therefore, the authors evaluated lung injury 27 h after reperfusion. They also investigated whether attenuation of lung injury with the A3 adenosine receptor agonist MRS3558 was sustained beyond the immediate time period. Methods:In intact-chest, spontaneously breathing cats in which the left lower lung lobe was isolated and subjected to 2 h of ischemia and 3 h of reperfusion, MRS3558 was administered before reperfusion. Animals were killed 3 or 27 h after reperfusion. Results:When compared with 3 h of reperfusion, at 27 h the left lower lobe showed reduced apoptosis and no change in inflammation, but increased edema. Increased edema of the nonischemic right lung and hypoxemia were observed at 27 h after left lower lobe reperfusion. Increases in phosphorylated p38 levels were found at 3 h of reperfusion compared with control lung, with further increases at 27 h. The attenuation of injury observed with MRS3558 treatment at 3 h of reperfusion was sustained at 27 h. Conclusions:Lung edema may worsen hours after the immediate postreperfusion period, even though lung apoptosis and inflammation are reduced or show no change, respectively. This was associated with further increases in phosphorylated p38 levels. The nonischemic lung may also be affected, suggesting a systemic response to reperfusion. In addition, early attenuation of injury is beneficial beyond the immediate period after reperfusion. Treatment aimed at inhibiting p38 activation, such as A3 receptor activation, should be further studied to explore its potential long-term beneficial effect.
Heterodox Theories of Economic Growth and Income Distribution: A Partial Survey

Heterodox theories of economic growth and income distribution are surveyed, focusing on major theories and recent contributions. First, a general framework for examining growth and distribution is discussed, in terms of which classicalâ€ Marxian and postâ€ Keynesianâ€“Kaleckian and other theories are presented. Since this framework examines how variables are determined in equilibrium, second, dynamics behind equilibria are examined, focusing on goods market and labor market changes. Third, the framework is extended in a variety of ways to examine additional models addressing productivity growth and technical change, money and inflation, finance and debt, additional distributional considerations, multisector issues, open economy questions, and the environment. It is concluded that the literature on heterodox theories of growth and distribution is vibrant, large, and growing, and addresses many issues that are ignored or neglected in orthodox theories, including power, unemployment, and aggregate demand.
Risk factors associated with higher body fat in US Army female soldiers.

UNLABELLED Increased body fat among US Soldiers is a continuing challenge that contributes to increased health risks and decreased combat readiness. Factors contributing to higher body fat among US Army female Soldiers have been minimally investigated. PURPOSE To investigate the risk factors associated with exceeding US Army body fat standards among active duty women in a light infantry brigade. Investigated risk factors include personal characteristics, physical training, physical fitness, and injury history. METHODS Data were obtained by survey from women in 3 US Army infantry brigades. Body fat percentage was calculated, and the women were categorized as either meeting or exceeding the maximum Army body fat standard of 30% for ages 17-20, 32% for ages 21-27, 34% for ages 28-39, and 36% for age 40 years or more. Army Physical Fitness Test (APFT) results were converted into tertiles (T), where T1=lowest 1/3 of performance and T3=highest 1/3 of performance. Odds ratios (OR) and 95% confidence intervals (CI) were calculated from a multivariate analysis assessing risk associated with exceeding the Army body fat standards. RESULTS Among the women surveyed (n=629), 22% exceeded Army body fat standards. Higher risk of being above the Army standard was associated with older age (≥29 years / ≤23 years) (OR=47, 95% CI, 1.24-4.92), and poor aerobic fitness (APFT 2-mile run) (T1/T3) OR=6.11, 95% CI, 2.62-14.24), (T1/T2) OR=2.66, 95% CI, 1.12-6.33). A marginal association was found for poor muscular strength (APFT sit-ups) (T1/T3). CONCLUSION The results suggest that women who are older, and/or have poor aerobic fitness are more likely to exceed the maximum Army body fat standards.
Analytical solutions of optimal portfolio rebalancing

We study optimal portfolio rebalancing in a mean-variance type framework and present new analytical results for the general case of multiple risky assets. We first derive the equation of the no-trade region, and then provide analytical solutions and conditions for the optimal portfolio under several simplifying yet important models of asset covariance matrix: uncorrelated returns, same non-zero pairwise correlation, and a one-factor model. In some cases, the analytical conditions involve one or two parameters whose values are determined by combinatorial, rather than numerical, algorithms. Our results provide useful and interesting insights on portfolio rebalancing, and sharpen our understanding of the optimal portfolio.
Mining Time-Resolved Functional Brain Graphs to an EEG-Based Chronnectomic Brain Aged Index (CBAI)

The brain at rest consists of spatially and temporal distributed but functionally connected regions that called intrinsic connectivity networks (ICNs). Resting state electroencephalography (rs-EEG) is a way to characterize brain networks without confounds associated with task EEG such as task difficulty and performance. A novel framework of how to study dynamic functional connectivity under the notion of functional connectivity microstates (FCμstates) and symbolic dynamics is further discussed. Furthermore, we introduced a way to construct a single integrated dynamic functional connectivity graph (IDFCG) that preserves both the strength of the connections between every pair of sensors but also the type of dominant intrinsic coupling modes (DICM). The whole methodology is demonstrated in a significant and unexplored task for EEG which is the definition of an objective Chronnectomic Brain Aged index (CBAI) extracted from resting-state data (N = 94 subjects) with both eyes-open and eyes-closed conditions. Novel features have been defined based on symbolic dynamics and the notion of DICM and FCμstates. The transition rate of FCμstates, the symbolic dynamics based on the evolution of FCμstates (the Markovian Entropy, the complexity index), the probability distribution of DICM, the novel Flexibility Index that captures the dynamic reconfiguration of DICM per pair of EEG sensors and the relative signal power constitute a valuable pool of features that can build the proposed CBAI. Here we applied a feature selection technique and Extreme Learning Machine (ELM) classifier to discriminate young adults from middle-aged and a Support Vector Regressor to build a linear model of the actual age based on EEG-based spatio-temporal features. The most significant type of features for both prediction of age and discrimination of young vs. adults age groups was the dynamic reconfiguration of dominant coupling modes derived from a subset of EEG sensor pairs. Specifically, our results revealed a very high prediction of age for eyes-open (R2 = 0.60; y = 0.79x + 8.03) and lower for eyes-closed (R2 = 0.48; y = 0.71x + 10.91) while we succeeded to correctly classify young vs. middle-age group with 97.8% accuracy in eyes-open and 87.2% for eyes-closed. Our results were reproduced also in a second dataset for further external validation of the whole analysis. The proposed methodology proved valuable for the characterization of the intrinsic properties of dynamic functional connectivity through the age untangling developmental differences using EEG resting-state recordings.
Drivers and Patterns of Ground-Dwelling Beetle Biodiversity across Northern Canada

Many macroecological patterns of biodiversity, including the relationship between latitude and species richness, are well-described. Data collected in a repeatable, standardized manner can advance the discipline beyond the description of patterns and be used to elucidate underlying mechanisms. Using standardized field methods and a hyper-diverse focal taxon, viz. Coleoptera, we aim to (1) describe large-scale latitudinal patterns of taxonomic diversity, functional diversity, and assemblage structure across northern Canada, and (2) determine which climatic, spatial, and habitat variables best explain these patterns. We collected terrestrial beetles at twelve locations in the three northernmost ecoclimatic zones in North America: north boreal, subarctic, and high arctic (51–81°N, 60–138°W). After identifying beetles and assigning them to a functional group, we assessed latitudinal trends for multiple diversity indices using linear regression and visualized spatial patterns of assemblage structure with multivariate ordinations. We used path analysis to test causal hypotheses for species and functional group richness, and we used a permutational approach to assess relationships between assemblage structure and 20 possible climatic and environmental mechanisms. More than 9,000 beetles were collected, representing 464 species and 18 functional groups. Species and functional diversity have significant negative relationships with latitude, which are likely explained by the mediating effects of temperature, precipitation, and plant height. Assemblages within the same ecoclimatic zone are similar, and there is a significant relationship between assemblage structure and latitude. Species and functional assemblage structure are significantly correlated with many of the same climatic factors, particularly temperature maxima and minima. At a large spatial extent, the diversity and assemblage structure of northern beetles show strong latitudinal gradients due to the mediating effects of climate, particularly temperature. Northern arthropod assemblages present significant opportunities for biodiversity research and conservation efforts, and their sensitivity to climate make them ideal targets for long-term terrestrial diversity monitoring.
Additive genetic relationships between heifer pregnancy and scrotal circumference in Hereford cattle.

The objective of this study was to determine an appropriate method for using yearling scrotal circumference observations and heifer pregnancy observations to produce EPD for heifer pregnancy. We determined the additive genetic effects of and relationship between scrotal circumference and heifer pregnancy for a herd of Hereford cattle in Solano, New Mexico. The binary trait of heifer pregnancy was defined as the probability of a heifer conceiving and remaining pregnant to 120 d, given that she was exposed at breeding. Estimates of heritability for heifer pregnancy and scrotal circumference were . 138+/-. 08 and . 714+/-. 132, respectively. Estimates of fixed effects for age of dam and age were significant for heifer pregnancy and bull scrotal circumference. The estimate of the additive genetic correlation between yearling heifer pregnancy and yearling bull scrotal circumference was . 002+/-. 45. Additional analyses included models with additive genetic groups for scrotal circumference EPD for heifer pregnancy or heifer pregnancy EPD for scrotal circumference to account for a potential nonlinear relationship between scrotal circumference and heifer pregnancy. Results support the development of a heifer pregnancy EPD because of a higher estimated heritability than previously reported. The development of a heifer pregnancy EPD would be an additional method for improving genetic merit for heifer fertility.
Creeping Bentgrass Putting Green Turf Responses to Two Irrigation Practices: Quality, Chlorophyll, Canopy Temperature, and Thatch-Mat

Frequent vs. infrequent irrigation are two common irrigation practices. This fi eld study was conducted on ‘Providence’ creeping bentgrass (Agrostis stolonifera L.) grown on a sand-based rootzone and maintained as a putting green. The objectives of this study were to measure several creeping bentgrass performance and physiological factors as infl uenced by light and frequent (LF) vs. deep and infrequent (DI) irrigation. The LF plots were irrigated daily to moisten the upper 4 to 6 cm of soil, while DI plots were irrigated at leaf wilt to wet soil to a depth of ≥24 cm. The LF-irrigated creeping bentgrass exhibited very good color and quality throughout most of 2006 and 2007, whereas DI-irrigated bentgrass exhibited acceptable quality in 2007 but not in 2006. The DI-irrigated bentgrass had lower chlorophyll levels in leaf and sheath tissue in 2006, but developed better color and quality and had higher chlorophyll levels in late summer of 2007 vs. LF-irrigated bentgrass. Creeping bentgrass subjected to DI irrigation developed a less thick thatch–mat layer that contained less organic matter than that found in LF-irrigated plots. Twice the amount of water was applied to the LF- vs. the DI-irrigated plots.
Digital rectal examination, serum prostate specific antigen, and prostatic ultrasound: How effective is this diagnostic triad?

Ninety‐nine of 105 consecutive men who underwent transrectal prostatic ultrasound (TRUS) at Highland Park Hospital had the results correlated with digital rectal examination (DRE), serum prostate specific antigen (PSA), and biopsy results. Ninety‐six cases had evaluable ultrasound studies. Thirty‐two of the 99 who underwent biopsy had primary carcinoma of the prostate. Prostate volume, predicted PSA, a ratio of observed/predicted PSA, and Gleason score were examined. There was no correlation between age and prostate volume, volume and the presence of carcinoma, or PSA and Gleason score. Thirty‐one point six percent of the abnormal DREs, 36.6% of the abnormal TRUSs, and 40.6% of the elevated PSAs occurred in men with prostatic carcinoma (PCa). If PSA was normal (less than or equal to 4.0 ng/ml) and either DRE or TRUS was abnormal, then the risk of carcinoma was 2.9%. If PSA was elevated, regardless of the other two tests, the risk of finding PCa was at least 38%. If all three tests were abnormal, the risk of carcinoma was 38% in our series and 68% in a meta‐analysis. Many men with PSA values between 4 and 10 ng/ml have benign biopsies. However, close future follow‐up with consideration of repeat biopsy should be strongly considered. © 1994 Wiley‐Liss, Inc.
Mutants of Escherichia coli K-12 exhibiting reduced killing by both quinolone and beta-lactam antimicrobial agents

Norfloxacin, ofloxacin, and other new quinolones, which are antagonists of the enzyme DNA gyrase, rapidly kill bacteria by largely unknown mechanisms. Earlier, we isolated, after mutagenesis, Escherichia coli DS1, which exhibited reduced killing by quinolones. We evaluated the killing of DS1 and several other strains by quinolones and beta-lactams. In time-killing studies with norfloxacin, DS1 was killed 1 to 2 log10 units compared to 4 to 5 log10 units for the wild-type parent strain KL16, thus revealing that DS1 is a high-persistence (hip) mutant. DS1 exhibited a similar high-persistence pattern for the beta-lactam ampicillin and reduced killing by drugs that differed in their affinities for penicillin-binding proteins, including cefoxitin, cefsulodin, imipenem, mecillinam, and piperacillin. Conjugation and P1 transduction studies identified a novel mutant locus (termed hipQ) in the 2-min region of the DS1 chromosome necessary for reduced killing by norfloxacin and ampicillin. E. coli KL500, which was isolated for reduced killing by norfloxacin without mutagenesis, exhibited reduced killing by ampicillin. E. coli HM23, a hipA (34 min) mutant that was isolated earlier for reduced killing by ampicillin, also exhibited high persistence to norfloxacin. DS1 differed from HM23, however, in the map location of its hip mutation, lack of cold sensitivity, and reduced killing by coumermycin. Results of these studies with strains DS1, KL500, and HM23 demonstrate overlap in the pathways of killing of E. coli by quinolones and beta-lactams and identify hipQ, a new mutant locus that is involved in a high-persistence pattern of reduced killing by norfloxacin and ampicillin.
Farmer's lung—a 5‐year follow‐up of eighty‐six patients

We studied the clinical course of eighty‐six patients with fanner's lung for a period of 5 years. The patients were first evaluated at an acute or sub‐acute stage of the disease and 1, 3, 6, 12 and 60 months thereafter. Special attention was paid to the development of lung function and radiological findings with reference to corticosteroid treatment and antigen contact during the follow‐up. Many of the patients were severely ill at the acute stage of the disease. Most of the recovery took place during the first month. Significant improvement of lung function happened up to 6 months, thereafter the improvement was insignificant. After 5 years, respiratory symptoms were reported by 65% and minor respiratory dysfunction (lowered diffusing capacity) was observed in about 40% of the farmers. Thirty‐two per cent of the patients showed diffuse opacities in chest X‐ray. Corticosteroid treatment had no effect on long term prognosis. There was no difference in the recovery of lung function between those who returned to work compared with those who did not. Exacerbations happened in 8% of the patients during the follow‐up. We conclude that respiratory symptoms, minor airway dysfunction and mild radiological fibrosis are common findings after 5 years of an acute or sub‐acute stage of the farmer's lung. However, in Finland two‐thirds of the patients return back to their previous occupation of farming and cattle feeding.
Spontaneous Blink Rate Correlates With Financial Risk Taking

Dopamine has long been thought to play a role in risky decision-making, with higher tonic levels of dopamine associated with more risk seeking behavior. In this work, we aimed to shed more light on this relationship using spontaneous blink rate as an indirect measure of dopamine. In particular we used video recording to measure blink rate and a decision-making survey to measure risk taking in 45 participants. Consistent with previous work linking dopamine to risky decisions, we found a strong positive correlation between blink rate and the number of risky choices a participant made. This correlation was not dependent on age or gender and was identical for both gain and loss framing. This work suggests that dopamine plays a crucial and quite general role in determining risk attitude across the population and validates this simple method of probing dopamine for decision-making research.
Assessing spatial planning strategy in high-speed rail station areas in Spain (1992–2018): towards a sustainable model

ABSTRACT The expansion of new national high-speed rail (HSR) networks, together with the emergence of a new urban paradigm, requires a reﬂection on previous experience, enabling the deﬁnition of better policy proposals for station-area planning. The HSR network in Spain oﬀers one of the world’s longest trajectories but in order to draw lessons from previous experience an appropriate analytical framework must be established, fulﬁlling at least three conditions: (a) inclusion of cases from diﬀerent periods -verifying an evolution or a constant pattern-; (b) basis in quantiﬁable parameters speciﬁc to HSR areas -allowing comparison among cases- and (c) coherence with contemporary planning criteria. With these three premises in mind, this paper builds a methodological framework analyzing parameters related to density, compactness, diversity of uses, public space, centrality and the barrier eﬀect, extracted from the comparative analysis of 12 approved Station-area Plans. The results show a common pattern that reveals a mixed urban model which combines compactness with the creation of large open spaces; as well as a progressive minimization of the barrier eﬀect over the last 25 years. The veriﬁcation of these results reinforces some hypotheses of the literature, but also introduces new criteria for incorporation into policy proposals for HSR stations.
Terrestrial gamma radiation dose study to determine the baseline for environmental radiological health practices in Melaka state, Malaysia

Environmental terrestrial gamma radiation dose rates were measured throughout Melaka, Malaysia, over a period of two years, with the objective of establishing baseline data on the background radiation level. Results obtained are shown in tabular, graphic and cartographic form. The values of terrestrial gamma radiation dose rate vary significantly over different soil types and for different underlying geological characteristics present in the study area. The values ranged from 54 ± 5 to 378 ± 38 nGy h−1. The highest terrestrial gamma dose rates were measured over soil types of granitic origin and in areas with underlying geological characteristics of an acid intrusive (undifferentiated) type. An isodose map of terrestrial gamma dose rate in Melaka was drawn by using the GIS application ‘Arc View’. This was based on data collected using a NaI(Tl) scintillation detector survey meter. The measurements were taken at 542 locations. Three small ‘hot spots’ were found where the dose rates were more than 350 nGy h−1. The mean dose rates in the main population areas in the mukims (parishes) of Bukit Katil, Sungai Udang, Batu Berendam, Bukit Baru and Bandar Melaka were 154 ± 15, 161 ± 16, 160 ± 16, 175 ± 18 and 176 ± 18 nGy h−1, respectively. The population-weighted mean dose rate throughout Melaka state is 172 ± 17 nGy h−1. This is lower than the geographical mean dose rate of 183 ± 54 nGy h−1. The lower value arises from the fact that most of the population lives in the central area of the state where the lithology is dominated by sedimentary rocks consisting of shale, mudstone, phyllite, slate, hornfels, sandstone and schist of Devonian origin which have lower associated dose rates. The mean annual effective dose to the population from outdoor terrestrial gamma radiation was estimated to be 0.21 mSv. This value is higher than the world average of 0.07 mSv.
Effect of Clonidine on Insulin Secretion: A Case Report

We have recently seen a case of non-insulin-dependent diabetes mellitus with hypertension in which chronic treatment with oral clonidine gave rise to elevation of blood glucose and decreased insulin secretion. When the response of insulin secretion to glucose administration during clonidine therapy was compared with that after 12 days of wash-out for clonidine in this patient (who was then receiving phentolamine mesylate), there was a marked suppression of insulin secretion to stimulation by intravenous glucose during oral clonidine therapy. This result indicates that the decreased insulin secretion associated with oral clonidine therapy is very unlikely to be due to any direct action of clonidine on β cells of the pancreatic islets and may be due to suppression of catecholamine release via central α-adrenergic receptor stimulation.