Miracle-dz/UniFAR-FTUs huggingface dataset:
Disability Behavior: Delayed Recovery in Employees with Work Compensable Injuries

The strong influence of social and psychological rather than medical factors affect delayed recovery in employees with work compensable Injuries. Several authors have noted that social factors are considered much more important than medical tactors to determine disability behavior (Derebery & TUllis, 1983; Weinstein, 1978; Yelln, Meenan, Nevitt, & Epstein, 1980). Attention has shitted from functional limitations due to disease entities to the psychosocial teetors associated with the accident or illness.The same Impairment will produce very different behavior in two different people (Brodsky,1983b; Derebery & Tullis, 1983; Larson & Sprietzer, 1970). Disability behavior is therefore learned, and there are many factors which influence the learning of this disabled role.
Does obstetric brachial plexus injury influence speech dominance?

Right‐handedness and left‐sided language lateralization is an unresolved mystery with unknown cause/effect relations. Most studies suggest that the language lateralization is related to a fundamental brain asymmetry: right‐handedness may be secondary. We analyzed the possibility of an opposite cause/effect relation: whether asymmetric hand usage (as a cause) can influence language lateralization (as a consequence).
Large eddy simulation of stably stratified open channel flow

Large eddy simulation has been used to study flow in an open channel with stable stratification imposed at the free surface by a constant heat flux and an adiabatic bottom wall. This leads to a stable pycnocline overlying a well-mixed turbulent region near the bottom wall. The results are contrasted with studies in which the bottom heat flux is nonzero, a difference analogous to that between oceanic and atmospheric boundary layers. Increasing the friction Richardson number, a measure of the relative importance of the imposed surface stratification with respect to wall-generated turbulence, leads to a stronger, thicker pycnocline which eventually limits the impact of wall-generated turbulence on the free surface. Increasing stratification also leads to an increase in the pressure-driven mean streamwise velocity and a concomitant decrease in the skin friction coefficient, which is, however, smaller than in the previous channel flow studies where the bottom buoyancy flux was nonzero. It is found that the tur.
Acute megakaryoblastic leukemia in Down syndrome

Children with Down syndrome (DS) have a 10‐ to 20‐fold increased risk of developing acute leukemia. An estimated 10% of newborns with DS develop Transient Myeloproliferative Disease (TMD) or Transient Leukemia (TL), a clonal accumulation of megakaryoblasts that resolves spontaneously within months. Acute megakaryoblastic leukemia (AMKL) develops in approximately 20% of cases of TMD/TL by 4 years of age. Both the blasts of AMKL and TMD/TL in DS harbor somatic mutations of GATA1, an essential transcriptional regulator of megakaryocytic differentiation. The distinct phenotypes of megakaryoblastic leukemia in DS are a unique biological model of the incremental process of leukemic transformation. Pediatr Blood Cancer 2007;49:1066–1069. © 2007 Wiley‐Liss, Inc.
Changes in the Compressive Nonlinearity of the Cochlea During Early Aging: Estimates From Distortion OAE Input/Output Functions

Objectives: The level-dependent growth of distortion product otoacoustic emissions (DPOAEs) provides an indirect metric of cochlear compressive nonlinearity. Recent evidence suggests that aging reduces nonlinear distortion emissions more than those associated with linear reflection. Therefore, in this study, we generate input/output (I/O) functions from the isolated distortion component of the DPOAE to probe the effects of early aging on the compressive nonlinearity of the cochlea. Design: Thirty adults whose ages ranged from 18 to 64 years participated in this study, forming a continuum of young to middle-age subjects. When necessary for analyses, subjects were divided into a young-adult group with a mean age of 21 years, and a middle-aged group with a mean age of 52 years. All young-adult subjects and 11 of the middle-aged subjects had normal hearing; 4 middle-aged ears had slight audiometric threshold elevation at mid-to-high frequencies. DPOAEs (2f1 − f2) were recorded using primary tones swept upward in frequency from 0.5 to 8 kHz, and varied from 25 to 80 dB sound pressure level. The nonlinear distortion component of the total DPOAE was separated and used to create I/O functions at one-half octave intervals from 1.3 to 7.4 kHz. Four features of OAE compression were extracted from a fit to these functions: compression threshold, range of compression, compression slope, and low-level growth. These values were compared between age groups and correlational analyses were conducted between OAE compression threshold and age with audiometric threshold controlled. Results: Older ears had reduced DPOAE amplitude compared with young-adult ears. The OAE compression threshold was elevated at test frequencies above 2 kHz in the middle-aged subjects by 19 dB (35 versus 54 dB SPL), thereby reducing the compression range. In addition, middle-aged ears showed steeper amplitude growth beyond the compression threshold. Audiometric threshold was initially found to be a confound in establishing the relationship between compression and age; however, statistical analyses allowed us to control its variance. Correlations performed while controlling for age differences in high-frequency audiometric thresholds showed significant relationships between the DPOAE I/O compression threshold and age: Older subjects tended to have elevated compression thresholds compared with younger subjects and an extended range of monotonic growth. Conclusions: Cochlear manifestations of nonlinearity, such as the DPOAE, weaken during early aging, and DPOAE I/O functions become linearized. Commensurate changes in high-frequency audiometric thresholds are not sufficient to fully explain these changes. The results suggest that age-related changes in compressive nonlinearity could produce a reduced dynamic range of hearing, and contribute to perceptual difficulties in older listeners.
Implementing the Kidney Disease: Improving Global Outcomes/acute kidney injury guidelines in ICU patients

Purpose of reviewAcute kidney injury (AKI) is a frequent finding in critically ill patients and is associated with adverse outcomes. With the purpose of improving outcome of AKI, the Kidney Disease: Improving Global Outcomes (KDIGO) group, a group of experts in critical care nephrology, has presented a set of guidelines in 2012, based on the evidence gathered until mid 2011. This review will update these guidelines with recent evidence. Recent findingsEarly application of a set of therapeutic measures – a bundle – is advised for the prevention and therapy of AKI. Hemodynamic optimization remains the cornerstone of prevention and treatment of AKI. Fluid resuscitation should be with isotonic crystalloids. Recent evidence demonstrated a higher risk for renal replacement therapy (RRT) and mortality in hydroxyethyl starch-exposed patients. Further, blood pressure should be maintained by the use of vasopressors in vasomotor shock. Nephrotoxic drugs should be avoided or stopped when possible. Contrast-associated AKI should be prevented by prehydration with either NaCl 0.9% or a bicarbonate solution. Other therapies, including intravenous N-acetylcysteine and hemofiltration are not recommended. Optimal timing of RRT remains controversial. Fluid overload remains an important determinant for the initiation of RRT. Continuous therapies are preferred in hemodynamically unstable patients; otherwise, choice of modality does not impact on outcomes. SummaryThe KDIGO guidelines as presented in 2012 provide guidelines on the domain of definition of AKI, prevention and treatment, contrast-induced AKI and dialysis interventions for AKI. Especially, early application of a set of measures, the AKI bundle, may prevent AKI and improve outcome.
Expression of Serine Protease Matriptase in Renal Cell Carcinoma: Correlation of Tissue Microarray Immunohistochemical Expression Analysis Results with Clinicopathological Parameters

Serine protease matriptase (matriptase) cleaves and activates proteins implicated in the progression of cancer and represents a potential therapeutic target. Immunohistochemical analysis of matriptase was performed in tissue microarrays of 168 renal cell carcinomas (RCCs). All subtypes of RCC showed significant immunohistochemical expression of matriptase. In contrast, no expression occurred in areas of RCC with sarcomatous differentiation (SRCC) and in normal collecting tubules. The matriptase scores were significantly higher in papillary RCC (341) and clear cell RCC with granular cell differentiation (GRCC; 324) than in other histologic subtypes of RCC. In GRCC, matriptase scores were correlated with TNM staging and nuclear grading. Matriptase was overexpressed in all subtypes of RCC, and matriptase scores could distinguish between conventional clear cell RCC, GRCC, and SRCC.
Tobacco, Marijuana, and Alcohol Use in University Students: A Cluster Analysis

Abstract Objective: Segmentation of populations may facilitate development of targeted substance abuse prevention programs. The authors aimed to partition a national sample of university students according to profiles based on substance use. Participants: The authors used 2008–2009 data from the National College Health Assessment from the American College Health Association. The sample consisted of 111,245 individuals from 158 institutions. Methods: The sample was partitioned using cluster analysis according to current substance use behaviors. The association of cluster membership with individual and institutional characteristics was examined. Results: Cluster analysis yielded 6 distinct clusters. Three individual factors—gender, year in school, and fraternity/sorority membership—were the most strongly associated with cluster membership. Conclusions: In a large sample of university students, the authors were able to identify 6 distinct patterns of substance abuse. It may be valuable to target specific populations of college-aged substance users based on individual factors. However, comprehensive intervention will require a multifaceted approach.
The contribution of MRI in assessing cognitive impairment in multiple sclerosis

Cognitive impairment affects a large proportion of patients with multiple sclerosis (MS) and has a profound impact on their daily-life activities. Improving the knowledge of the pathophysiology of cognitive impairment in MS and of the mechanisms responsible for its evolution over time might contribute to development of better outcome measures and targets for innovative treatment strategies. Due to their ability to detect MS-related abnormalities, MRI techniques are a valuable tool to achieve these goals. Following an updated overview of the assessment methods and profile of cognitive impairment in patients with MS, this review provides a state-of-the-art summary of the main results obtained from the application of conventional and modern magnetic resonance– based techniques to quantify MS-related damage, in terms of macroscopic lesions, as well as involvement of the normal-appearing white matter and gray matter and their association with cognitive impairment. The possible role of brain cortical reorganization in limiting the clinical consequences of disease-related damage is also discussed. Finally, the utility of the previous techniques to monitor the progression of cognitive deficits over time and the efficacy of possible therapeutic strategies is considered.
Surgical Repair of Complete Proximal Hamstring Tendon Rupture *

Background: Complete proximal hamstring tendon rupture is a rare injury associated with significant functional loss. Nonoperative treatment has proven inadequate in returning patients to their previous activity level. Purpose: We wanted to describe the outcome of primary surgical repair of the proximal hamstring tendon avulsion. Study Design: Retrospective cohort study. Methods: Between 1994 and 1999, 11 patients (4 women and 7 men) with an average age of 41.5 years (range, 21 to 51) had a diagnosis of complete proximal hamstring tendon rupture based on mechanism of injury, physical examination, and radiographic assessment. All underwent a single operation followed by standard postoperative physical therapy. At the latest follow-up (average, 34 months), patients completed a questionnaire regarding such outcome parameters as pain, function, leg control, stiffness, return to activity, and overall satisfaction. Results: Isokinetic muscle testing revealed an overall average of 91% return of hamstring muscle strength. Ten of 11 patients were satisfied with the result, and 7 of 9 athletically active patients were able to return to sport an average of 6 months (range, 3 to 10) after surgery. No difference between early and late repairs was identified in regard to functional outcome or return to sport. Conclusions: Satisfactory results can be achieved with both early and late hamstring tendon repairs in a majority of cases with surgical repair.
Green revolutions and miracle economies: Agricultural innovations, trade and growth

Abstract The purpose of this paper is to develop a simple model of an economy in which growth is driven by a combination of exogenous technical change in agriculture and a rising world demand for labor-intensive manufactured exports. We explore the relative roles of an exogenous agricultural productivity shock and rising export demand in a model with two traded industrial goods and a non-traded agricultural good, food. When the non-traded sector uses a specific factor, we show that technical change in agriculture may be the key to factor migration into industry, in particular driving intersectoral labor migration. A key assumption is a less than unitary price elasticity of demand for food. Our results could form a crucial link in capturing the story of labor-abundant economies which experienced structural transformation and growth through labor-intensive manufactured exports, without prior technology breakthroughs in industry. They contribute to explaining the massive growth in factor accumulation which shows up in some growth accounting studies: they may also imply that some of the contribution of ‘technical progress’ is mistakenly attributed solely to factor accumulation.
Cytologic and Functional Alterations of Nasal Mucosa in Smokers

Objective Tobacco smoke is a significant risk factor for respiratory diseases. The purpose of this study is to analyze the cytologic and functional features of nasal mucosa in smokers, nonsmokers, and ex-smokers to evaluate if nasal alterations in smokers are permanent or reversible conditions after smoking cessation. Study Design Case series with planned data collection. Setting University medical center. Subjects and Methods Ninety healthy volunteers recruited from the staff of Alfredo Fiorini Hospital, Sapienza University of Rome, were enrolled in this prospective study from October to November 2013. We divided the cases according to smoking habits (smokers, nonsmokers, ex-smokers). Each group was composed of 30 subjects. Cytologic features of nasal mucosa and effectiveness of nasal mucociliary clearance were studied, focusing on 4 parameters: (1) nasal mucociliary clearance, assessed by saccharin nasal transit time; (2) ratio between the number of ciliated cells and goblet cells, analyzed by microscopic observation of cytologic specimens of nasal mucosa that had undergone May Grunwald Giemsa staining; (3) evaluation of ciliary motility; and (4) time of ciliary movement of ciliated cells analyzed by phase-contrast microscopy. Results All parameters were significantly reduced in the smokers compared to the nonsmokers. There were no statistically significant differences between the nonsmoker and ex-smoker groups. Conclusion Cigarette smoking causes cytologic modifications of nasal mucosa that influence the effectiveness of mucociliary clearance. Our preliminary study suggests that these changes are not permanent and that nasal mucosa of ex-smokers recovers normal cytologic and functional features.
Influence of melatonin implantation on sperm quality, biochemical composition of the seminal plasma and plasma testosterone levels in rams

SUMMARY Influence of the melatonin implantation on sperm quality, plasma testosterone levels and biochemical composition of the seminal plasma was evaluated in rams in the breeding and non-breeding season. Melatonin administration during the non-breeding season improved progressive motility and morphologically normal sperm rates. The mean plasma testosterone level was significantly higher in melatonin treated animals compared to untreated ones. Fructose, sodium, calcium, magnesium levels, and aspartate aminotransferase and lactate dehydrogenase activity in the seminal plasma were similar in melatonin treated and control rams. In contrast, melatonin administration during the breeding season did not enhance spermatologic parameters and plasma testosterone levels. Biochemical composition of the seminal plasma was also comparable in melatonin treated and untreated control groups. In conclusion, melatonin administration during the breeding season did not influence sperm quality, plasma testosterone levels and biochemical parameters evaluated in this study.
Rothberger's property and partition relations

Let X be an infinite but separable metric space. An open cover of X is said to be large if for each x ϵ X the set {U ϵ : x ϵ U} is infinite. The symbol Λ denotes the collection of large open covers of X. An open cover of X is said to be an ω-cover if for each finite subset F of X there is a U ϵ such that F ⊆ U, and X is not a member of , X is said to have Rothberger's property if there is for every sequence (n : n = 1,2,3,…) of open covers of X a sequence (Un : n = 1,2,3,…) such that: (1) for each n, Un is a member of n, and (2) {Un: n = 1,2,3,…} is a cover of X. Rothberger introduced this property in his paper [2]. For convenience we let denote the collection of all open covers of X. In [3] it was shown that X has Rothberger's property if, and only if, the following partition relation is true for large open covers of X: This partition relation means: for every large cover of X, for every coloring such that for each U ϵ and each large cover there is an i with a large cover of X, either there is a large cover such that f({A, B}) = 0 whenever {A,B} ϵ , or else there is a which is not point–finite such that f{{A, B}) = 1 whenever {A, B} ϵ .
Trends in Doctor Consultations, Antibiotic Prescription, and Specialist Referrals for Otitis Media in Children: 1995–2003

BACKGROUND. Reported trends regarding the incidence of otitis media and antibiotic prescription rates are inconsistent. OBJECTIVE. Our goal was to assess changes in incidence of consultation rates, antibiotic prescription, and referral rates for otitis media in children over the years 1995–2003. METHODS. A cohort study including all children aged 0 to 13 years within the research database of the Netherlands University Medical Center Utrecht Primary Care Network covering the period 1995–2003. Otitis media diagnoses were recorded according to the International Classification of Primary Care codes and antibiotic prescription according to the Anatomic Therapeutic Chemical Classification System codes. Otitis media incidence rates were calculated as episodes per 1000 person-years. Antibiotic prescription and referral rates were calculated per 100 otitis media episodes. RESULTS. From 1995 to 2003, the overall general practitioner consultation rates for acute otitis media and otitis media with effusion declined by 9% and 34%, respectively. In children aged 2 to 6 years and those aged 6 to 13 years, the incidence rates of acute otitis media and otitis media with effusion declined by 15% and 41% and 40% and 48%, respectively. In children <2 years of age, the incidence rates of acute otitis media and otitis media with effusion increased by 46% and 66%, respectively. Antibiotic prescription rates for acute otitis media and otitis media with effusion increased by 45% and 25%, respectively. The referral rate for acute otitis media did not change, whereas the referral rate for otitis media with effusion increased by 45%. CONCLUSIONS. Consultation rates for otitis media have changed considerably over the last decade, and so have antibiotic prescriptions and specialist referrals. The rising antibiotic prescription rate for otitis media causes concern, because this may induce increasing medical costs and antibiotic resistance.
Transient Inhibition of Translation Initiation by Osmotic Stress*

Cells respond and adapt to changes in the environment. In this study, we examined the effect of environmental stresses on protein synthesis in the yeast Saccharomyces cerevisiae. We found that osmotic stress causes irreversible inhibition of methionine uptake, transient inhibition of uracil uptake, transient stimulation of glucose uptake, transient repression of ribosomal protein (RP) genes such as CYH2 andRPS27, and the transient inhibition of translation initiation. Rapid inhibition of translation initiation by osmotic stress requires a novel pathway, different from the amino acid-sensing pathway, the glucose-sensing pathway, and the TOR pathway. The Hog1 MAP kinase pathway is not involved in the inhibition of either methionine uptake or translation initiation but is required for the adaptation of translation initiation after inhibition and the repression of RP genes by osmotic stress. These results suggest that the transient inhibition of translation initiation occurs as a result of a combination of both acute inhibition of translation and the long-term activation of translation by the Hog1 pathway.
Proportional Integral Derivative Charts for Process Monitoring

We introduce a new class of monitoring procedures based on the relationship between a proportional integral derivative (PID) feedback control scheme and the corresponding prediction scheme. The charts are obtained by applying the PID predictor to the autocorrelated data to get residuals and then monitoring the residuals. This class of procedures includes as special cases several charts that have been recently proposed in the literature and thus provides a unifying framework. The PID charts have three parameters that can be suitably tuned to achieve good average run length (ARL) performance for large or small mean shifts. Methods for determining chart parameters to obtain good ARL performance are discussed. Simulation studies for autoregressive moving average (1, 1) models show that PID charts are competitive with the special cause charts of Alwan and Roberts for detecting large shifts and perform better in detecting small to moderate shifts. The effects of model parameter misspecification and bias in estimating the variance of the residuals are investigated in a robustness study.