Miracle-dz/UniFAR-FTUs huggingface dataset:
Tubulin and CRMP‐2 complex is transported via Kinesin‐1

The transport of tubulin and microtubules in a growing axon is essential for axonal growth and maintenance. However, the molecular mechanism underlying the linkage of tubulin and microtubules to motor proteins is not yet clear. Collapsin response mediator protein‐2 (CRMP‐2) is enriched at the distal part of growing axons in primary hippocampal neurons and plays a critical role in axon differentiation through its interaction with tubulin dimer and Numb. In this study, we show that CRMP‐2 regulates tubulin transport by linking tubulin and Kinesin‐1. The C‐terminal region of CRMP‐2 directly binds to the tetratricopeptide repeat domain of kinesin light chain 1 (KLC1). Soluble tubulin binds to the middle of CRMP‐2 and forms a trimeric complex with CRMP‐2/KLC1. Furthermore, the movement of GFP–tubulin in the photobleached area is weakened by knockdown of KLCs or CRMP‐2. These results indicate that the CRMP‐2/Kinesin‐1 complex regulates soluble tubulin transport to the distal part of the growing axon.
Does a Satisfied Customer Care about Price? The Link between Customer Satisfaction and Price Sensitivity in the Commercial Martial Arts Industry

ABSTRACT Extensive research has shown that customer satisfaction is an important driver of profitability. However, academic understanding of pricing outcomes associated with customer satisfaction evaluations is limited. The purpose of this study was to investigate the relationship between customer satisfaction and price sensitivity, while also examining the moderating effects of gender and participation frequency. Results indicated that four dimensions of customer satisfaction have an inverse effect on customer price sensitivity. Results also showed that there were significant differences on the linkage between customer satisfaction and price sensitivity across gender and participation frequency groups. These findings illuminate concerns among martial arts consumers which are most likely to prompt an exploration of alternative purchase choices in attempt to seek fairer pricing. They also identify individual characteristics among martial arts segments which can be used to build pricing strategy.
Improved 3D spiral imaging for coronary MR angiography

Thin‐slab 3D spiral imaging has been used for MR angiography to image selected coronary arteries. Improved scan efficiency was achieved using a train of multiple spiral interleaves within each single R‐R interval acquired in the late diastole. Data acquisition was performed during free breathing, using navigator gating. Additionally, prospective slice tracking was applied to further reduce the sensitivity to motion. The application of a T2‐preparation pulse and fat suppression increased the contrast between blood and myocardium. Experiments performed on healthy volunteers are presented to show the feasibility of this approach, which allows coronary artery imaging of selected vessels within a few minutes. Magn Reson Med 45:172–175, 2001. © 2001 Wiley‐Liss, Inc.
Loss factors for learning Boosting ensembles from imbalanced data

Class imbalance is an issue in many real world applications because classification algorithms tend to misclassify instances from the class of interest when its training samples are outnumbered by those of other classes. Several variations of AdaBoost ensemble method have been proposed in literature to learn from imbalanced data based on re-sampling. However, their loss factor is based on standard accuracy, which still biases performance towards the majority class. This problem is mitigated using cost-sensitive Boosting algorithms, although it can be avoided at the outset by modifying the loss factor calculation. In this paper, two loss factors, based on F-measure and G-mean are proposed that are more suitable to deal with imbalanced data during the Boosting learning process. The performance of standard AdaBoost and of three specialized versions for class imbalance (SMOTEBoost, RUSBoost, and RB-Boost) are empirically evaluated using the proposed loss factors, both on synthetic data and on a real-world face re-identification task. Experimental results show a significant performance improvement on AdaBoost and RUSBoost with the proposed loss factors.
From China with Love: The Role of FDI from Third Countries on EU Competition and R&D Activities

This report presents empirical analysis on the linkage between mergers and acquisition FDI and acquirer innovation efforts. The data indicates that acquisitions tend to result in a spike in research in the two following years. This impact, however, is contingent on industrial linkages between target and acquirer. In particular, nonmanufacturing targets appear to have the largest impact. Further investigation using input-output linkages finds that acquirer R&D increases more when the target is a primary source of inputs for the acquirer. These effects, however, are smaller for Chinese acquirers, suggesting that concerns over whether acquisition of foreign technology is spurring faster Chinese technological growth may be misguided. Finally, these effects are smaller in more concentrated industries, suggesting the need to consider industry concentration when projecting the R&D implications of cross-border mergers.
Monolithic mode-locked erbium-doped LiNbO3 waveguide laser with dielectric multilayer mirror

We fabricated a diode-pumped mode-locked Ti-diffused Er-doped LiNbO3 (Ti:Er:LN) laser with a SiO2/TiO2 dielectric multi-layered mirror. The lasing threshold power was 70mW at 1484nm, and the slope efficiency was 1.48%. Stable optical pulses with a width of 10.86ps were measured by driving the phase modulator at 13.575GHz.
Assessing eLearning Systems Success in Nigeria: An Application of the DeLone and McLean Information Systems Success Model

Aim/Purpose: This study is based on the DeLone and McLean's Information Systems Success (D & M ISS) model, which was modified to determine the success factors re-sponsible for the acceptance of an e-learning system called Canvas by students of a Nigerian University. Background: The adoption of eLearning has been under studied within the context of devel-oping countries. There have been calls in the literature for further research from a developing country perspective. This study attempts to fill this knowledge gap by investigating the factors responsible for students' adoption of eLearning in a Nigerian University. Methodology: The study was built on the premise that system quality (SQ), service quality (ServQ) and information quality (IQ) are determinants of behavioral intention to use Canvas and user satisfaction of Canvas, both of which in turn influence the actual usage of Canvas. Responses from 366 students were analyzed with AMOS 22 using structural equation model (SEM) to test the relationships be-tween the constructs of the proposed model. Contribution: The study contributes to the research gap about the paucity of studies in the adoption of eLearning in developing countries that have placed emphasis on the use of eLearning systems or on the software quality attributes of the sys-tems under investigation. Findings: The results partially supported the effect of the quality antecedents on behav-ioral intention and user satisfaction of students. There was full support for the relationship between behavioral intention and user satisfaction of students on their actual usage of Canvas. Recommendations for Practitioners: The level of significance of the constructs identified in the study will guide the formulation of strategies and methods that could further enhance the adoption of eLearning systems in developing countries, specifically Nigeria. Recommendation for Researchers: Theoretically, the study contributes to the body of knowledge on eLearning adoption by empirically validating the DeLone and McLean model in a different context, specifically sub-Saharan Africa. Future Research: Future research could investigate the factors that influence instructors' behav-ioral intentions to use eLearning applications and also the effect that the in-structors have on students' adoption of eLearning.
Exploring Relationships Between Customer Satisfaction and Customer Attitude from Customer Relationship Management Viewpoint: An Empirical Study of Leisure Travellers

In the business world, customer relationship management (CRM) has emerged as the main marketing activity of the service firms. Organizations thrive to maintain long-lasting relationships with their customers. The priority of the firms is to maximize the relationship share (RS) with profitable customers. The current study aims at identifying determinants of RS for hotels leisure travellers. The findings indicate that customer satisfaction (CS) and attitude towards the hotel in the relationship are major predictors of RS. Besides, CS indirectly affects RS through customer’s attitude towards the hotel. The findings of the present study will help the practitioners to design CRM programme better and reap its maximum benefits.
Lipiodol accumulation and transarterial chemoembolization efficacy for HCC patients.

BACKGROUND/AIMS To elucidate the prognostic factors for hepatocellular carcinoma (HCC) patients treated with transarterial chemoembolization (TACE). METHODOLOGY We studied 85 TACE-treated HCC patients, including 117 lesions, who fulfilled the Milan criteria. The area of iodized poppy-seed oil (lipiodol) accumulation on CT immediately after TACE was classified into three groups, by comparing with the area of HCC detected by CT during hepatic arteriography; accumulation surrounding the HCC lesion (group I), accumulation involving the entire area of the HCC lesion (group II), and accumulation that covered a portion of the HCC lesion (group III). RESULTS Among 85 patients, the 1- and 2-year disease free survival (DFS) rates were 67% and 50% in group I, 49% and 29% in group II and 29% and 15% in group III. DFS rate was higher in group I than in groups II and III (p=0.016 and p<0.001). Difference in DFS by lipiodol accumulation pattern was evident in patients aged 75 or younger. CONCLUSIONS Lipiodol accumulation pattern as evaluated by CT immediately after TACE may be a powerful indicator of the therapeutic efficacy of TACE in HCC patients.
CV2/CRMP5-antibody-related Paraneoplastic Optic Neuropathy Associated with Small-cell Lung Cancer

A 61-year-old woman who had smoked for 41 years developed subacute dizziness, ataxic gait, opsoclonus, and right visual impairment. She had right optic disc swelling and optic nerve gadolinium enhancement on magnetic resonance imaging. She had small-cell lung cancer (SCLC), with CV2/collapsin response mediator protein (CRMP)5 and HuD antibodies in her serum and cerebrospinal fluid. She was diagnosed with paraneoplastic optic neuropathy (PON) accompanied by paraneoplastic opsoclonus-ataxia syndrome. Her symptoms improved after removing the SCLC. Classical PON is rare in Japan. We recommend assaying for CV2/CRMP5 antibodies and searching for cancer in elderly patients with subacute painless visual impairment.
Chronic Fatigue Self-Management in Primary Care: A Randomized Trial

Objective To assess the efficacy of brief fatigue self-management (FSM) for medically unexplained chronic fatigue (UCF) and chronic fatigue syndrome (CFS) in primary care. Methods A randomized controlled design was used wherein 111 patients with UCF or CFS were randomly assigned to two sessions of FSM, two sessions of symptom monitoring support (attention control; AC), or a usual care control condition (UC). Participants were assessed at baseline and at 3 and 12 months after treatment. The primary outcome, the Fatigue Severity Scale, measured fatigue impact on functioning. Analysis was by intention to treat (multiple imputation) and also by per protocol. Results A group × time interaction across the 15-month trial showed significantly greater reductions in fatigue impact in the FSM group in comparison with the AC group (p < .023) and the UC group (p < .013). Medium effect sizes for reduced fatigue impact in the FSM group were found in comparison with the AC group (d = 0.46) and the UC group (d = 0.40). The per-protocol analysis revealed large effect sizes for the same comparisons. Clinically significant decreases in fatigue impact were found for 53% of participants in the FSM condition, 14% in the AC condition, and 17% in the UC condition. Dropout rates at the 12-month follow-up were high (42%–53%), perhaps attributable to the burden of monthly telephone calls to assess health care use. Conclusion A brief self-management intervention for patients with UCF or CFS seemed to be clinically effective for reducing the impact of fatigue on functioning. Trial Registration clinicaltrials.gov Identifier: NCT00997451.
Visual word learning in skilled readers of English

Three experiments are reported analysing the processes by which adult readers of English learn new written words. Visual word learning was simulated by presenting short (four-letter) and longer (seven-letter) nonwords repeatedly and observing the reduction in naming latencies and the convergence in reaction times (RTs) to shorter and longer items that are the hallmarks of visual word learning. Experiment 1 presented nonwords in ten consecutive blocks. Naming latencies reduced over the first four or five presentations. The effect of length on naming RTs was large in block 1 but non-significant after four or five presentations. Experiment 2 demonstrated some reduction in RTs to untrained nonwords following practice on a trained set, but the reduction was less than for the trained items and RTs to shorter and longer nonwords did not converge. Experiment 3 included a retest after seven days which showed some slowing of RTs compared with the end of the first session but also considerable retention of learning. We conclude that four to six exposures to novel words (nonwords) are sufficient to establish durable lexical representations that permit parallel processing of newly-learned words. The results are discussed in terms of theoretical models of reading and word learning.
Influence of Leadership Style on Performance of Construction Projects: a Case of Housing Projects in Westlands Sub-county, Nairobi Kenya.

xi CHAPTER ONE INTRODUCTION . 1 1.1 Background to the Study . 1 1.2 Problem statement . 2 1.3 Purpose of the Study . 4 1.4 Objectives of the study . 4 1.5 Research Questions . 4 1.6 Significance of Study . 4 1.7 Basic Assumptions . 5 1.8 Limitations of Study . 5 1.9 Delimitations of the Study. 6 1.10 Definition of Significant Terms. 6 1.11 Organization of the study . 7 CHAPTER TWO LITERATURE REVIEW . 8 2.
BIOSORPTION FOR METAL IONS REMOVAL FROM AQUEOUS SOLUTIONS: A REVIEW OF RECENT STUDIES

The presence of metal ions in aqueous solutions represents a major environmental problem. These inorganic species are persistent and non-biodegradable pollutants that should be eliminated from water. In the recent years biosorption have emerged as an economical and environmental friendly method for the decontamination of polluted water. The present work represents a review of the recently published literature discussing the use of non-modified biosorbents for the removal of metal ions from aqueous solution. In this review the main classes of biomass materials used as biosorbents are discussed along with the principle factors affecting the biosorption process such as: solution pH, biomass dose, metal ion concentration and contact time. The potential health and environmental hazards of metal ions in addition to the kinetic and isothermal models usually assessed to fit the biosorption experimental data were also reviewed.
Methodological Assumptions of DETE Project Revisited: Association-based Learning Requires Complex Architectures

Taylor & Francis makes every effort to ensure the accuracy of all the information (the “Content”) contained in the publications on our platform. However, Taylor & Francis, our agents, and our licensors make no representations or warranties whatsoever as to the accuracy, completeness, or suitability for any purpose of the Content. Any opinions and views expressed in this publication are the opinions and views of the authors, and are not the views of or endorsed by Taylor & Francis. The accuracy of the Content should not be relied upon and should be independently verified with primary sources of information. Taylor and Francis shall not be liable for any losses, actions, claims, proceedings, demands, costs, expenses, damages, and other liabilities whatsoever or howsoever caused arising directly or indirectly in connection with, in relation to or arising out of the use of the Content.
Downstream factor of beef cattle company economic sustainability

Article history: Received 24 September 2018 Received in revised form 15 February 2019 Accepted 1 April 2019 The purpose of this study is to examine the index of each application aspect or dimension that is an indicator of the sustainability of beef cattle business in hopes of providing solutions for the beef cattle industry to increase production and income. This study uses a mixed method approach by collecting data through interviews and questionnaires. This research was conducted in one district in Indonesia. The results of the study show that there are several things that have become recommendations in this study in their efforts to maintain the sustainability of beef cattle business, namely. Aspects of the application of the marketing mix are still weak, so it needs to be well organized, especially for marketing and promotion and services. Also, product readiness must always be available in a certain amount for customer satisfaction to achieve economic benefits. In the management aspects of a professional organization, it is recommended that improvements be made in and need to complete deficiencies and also need restructuring and need to recruit experts and place them in accordance with their expertise.
Modified GPSR Based Optimal Routing Algorithm for Reliable Communication in WSNs

Geographic routing is one of the most widely used routing strategies in large-scale wireless sensor networks (WSN). With location-based routing, small, cheap and resource constrained nodes can perform the routing function without the need of complex computations and large amount of memory space. In the traditional approach, nodes advertise their availability to update the routing table. We eliminate this to reduce energy consumption. We introduce Modified Greedy Perimeter Stateless Routing (GPSR) routing protocol for efficient communication among sensor nodes, which identifies optimal route based on energy utilization. The implementation of GPSR in sensor networks faces many challenges due to limited memory and battery energy on each node, frequent change of network topology and unreliable infrastructure. Our Modified-GPSR approach results in near-optimal communication cost across the network. The simulation results prove that the energy and delay in minimized and substantially increases the network lifetime of sensor node. The proposed protocol outperforms the existing routing protocol for WSNs.
Genital herpes in a sexually-transmitted infection clinic in Singapore: a 1-year retrospective study.

INTRODUCTION This study describes the clinical features of genital herpes seen in a sexually-transmitted infection (STI) clinic in Singapore and the characteristics of the affected population. The distribution of herpes simplex virus (HSV) subtypes within the population, correlation of HSV culture result with duration of disease and prescribing habits of doctors were also examined. MATERIALS AND METHODS This is a retrospective study of cases of genital herpes seen at the Department of Sexually-transmitted Disease Control (DSC) clinic over a 1-year period. All records of clinically diagnosed HSV genital infections at the DSC clinic in 2001 were retrieved and reviewed and the data collated. RESULTS There were 324 cases of genital herpes, of which 153 (47.2%) were first-episode and 171 (52.8%) were recurrent HSV infections. There were 259 males and 65 females; their mean age was 35.2 years (range, 17 to 75 years). Of the 241 cases with positive culture results, 28 (11.6%) tested positive for herpes simplex virus type 1 (HSV-1) and 213 (88.4%) were positive for herpes simplex virus type 2 (HSV-2). HSV-1 accounted for 19.3% of first-episode and 4.7% of recurrent infections. HSV-2 accounted for 80.7% of first-episode and 95.3% of recurrent infections. Cultures taken from lesions < or = 4 days, between 5 and 7 days and > 7 days of onset were positive in 79.2%, 75.7% and 75% of cases, respectively. Oral acyclovir was prescribed more commonly in females (53.8%) than in males (21.6%). CONCLUSION Genital herpes is a common STI seen at the DSC clinic. HSV-2 is the most common cause of genital herpes and accounts for most of the recurrent cases seen.
Wavelet-OFDM versus filtered-OFDM in power line communication systems

Filtered orthogonal frequency division multiplexing (filtered-OFDM) and wavelet-OFDM are two modulation methods that have been proposed by the IEEE P1901 working group for data transmission over power lines. The filtered-OFDM is a modified version of the conventional OFDM that is designed to avoid the AM and amateur radio bands effectively. Although OFDM is a matured technology and thus it might be a preferred technology for most of the PLC industry (e.g., HomePlug Powerline Alliance), the acceptance of wavelet-OFDM as an alternative technology is because of a number of appealing advantages that it offers. The goal of this paper is to provide a bandwidth efficiency comparison of filtered-OFDM and wavelet-OFDM.
Thalidomide inhibits lipoarabinomannan-induced upregulation of human immunodeficiency virus expression

Mycobacterium tuberculosis accelerates the progression of human immunodeficiency virus type 1 (HIV-1) infection. The results of this study, which show that thalidomide inhibits the upregulation of HIV-1 expression in U1 cells stimulated with mycobacterial lipoarabinomannans, support the rationale behind conducting controlled trials of this immunodeficiency agent with patients dually infected with HIV-1 and M. tuberculosis.
Minimax Search Algorithms With and Without Aspiration Windows

Investigation of several algorithms for computing exact minimax values of game trees (utilizing backward pruning) are discussed. The focus is on trees with an ordering similar to that actually found in game playing practice. The authors compare the algorithms using two different distributions of the static values, the uniform distribution and a distribution estimated from practical data. A systematic comparison of using aspiration windows for all of the usual minimax algorithms is presented. The effects of aspiration windows of varying size and position are analyzed. Increasing the ordering of moves to near the optimum results in unexpectedly high savings. Algorithms with linear space complexity benefit most. Although the ordering of the first move is of predominant importance, that of the remainder has only second-order effects. The use of an aspiration window not only makes alpha-beta search competitive, but there also exist dependencies of its effects on certain properties of the trees. >