Miracle-dz/UniFAR-FTUs huggingface dataset:
Adipose tissue-derived omentin-1 attenuates arterial calcification via AMPK/Akt signaling pathway

Adipose tissue-derived adipokines mediate various kind of crosstalk between adipose tissue and other organs and thus regulate metabolism balance, inflammation state as well as disease progression. In particular, omentin-1, a newly found adipokine, has been reported to exhibit anti-calcification effects in vitro and in vivo. However, little is known about the function of endogenous adipose tissue-derived omentin-1 in arterial calcification and the detailed mechanism involved. Here, we demonstrated that global omentin-1 knockout (omentin-1-/-) resulted in more obvious arterial calcification in 5/6-nephrectomy plus high phosphate diet treated (5/6 NTP) mice while overexpression of omentin-1 attenuated attenuates osteoblastic differentiation and mineralisation of VSMCs in vitro and 5/6 NTP-induced mice arterial calcification in vivo. Moreover, we found that omentin-1 induced AMPK and Akt activation while inhibition of AMP-activated protein kinase (AMPK) and Akt signaling reversed the anti-calcification effect induced by omentin-1 both in vitro and in vivo. Our results suggest that adipose tissue-derived omentin-1 serves as a potential therapeutic target for arterial calcification and cardiovascular disease.
Oral Candidiasis in Cancer Patients undergoing chemotherapy

Background: Within the past two decades, Candida species have emerged as major human pathogens and are currently the fourth most common cause of nosocomial infection. Propose of this study was to determine the occurrence of oral Candidiasis among cancer patients at Tikrit Teaching Hospital. Methodology: 102 cancer patients were examined for oral candidiasis. For all patients, the clinical diagnosis had to be confirmed microbiologically by the presence of yeasts and / or hyphae or pseudohyphae on potassium hydroxide– treated smears of oral swabs. Oral samples were obtained and cultured on Sabouraud's dextrose agar and BCG agar. Results: 102 patients 45% positive culture, increasing incidence oral candidiasis with increasing age high results in over 60 years old, 67.3% were femeales and 32.7% were males, type of cancers 88.8% were hematological tumor and 40.8% were solid tumor. From these patients, 46 Candida spp were isolated; 63.3 % episodes of thrash. For C. albicans isolates, and 36.7% non-albicans candida( C. parapsolisis 7% , C. tropicalis 8.4% , C. glabrata 6% and C. krusei 5% ) . Conclusion: the finding of our study strongly suggest that oral candidiasis is a frequent complication among cancer patients, being C. albicans the main etiological agent
Effectiveness and acceleration of bone repair in critical‐sized rat calvarial defects using low‐level laser therapy

Tissue regeneration remains a challenge for orthopedic and craniomaxillofacial surgery to treat bone loss. The use of low‐level laser therapy suggests a promise on this road with positive results for narrow defects. However, temporal and quantitative evaluations are required to understand the healing process of large injuries. The aim of this study was to investigate the repair of critical‐size bone defects in rat calvaria using a GaAlAs laser.
Automated Classification of Overfitting Patches With Statically Extracted Code Features

Automatic program repair (APR) aims to reduce the cost of manually fixing software defects. However, APR suffers from generating a multitude of overfitting patches, those patches that fail to correctly repair the defect beyond making the tests pass. This paper presents a novel overfitting patch detection system called ODS to assess the correctness of APR patches. ODS first statically compares a patched program and a buggy program in order to extract code features at the abstract syntax tree (AST) level, for the single programming language Java. Then, ODS uses supervised learning with the captured code features and patch correctness labels to automatically learn a probabilistic model. The learned ODS model can then finally be applied to classify new and unseen program repair patches. We conduct a large-scale experiment to evaluate the effectiveness of ODS on patch correctness classification based on 10,302 patches from Defects4J, Bugs.jar and Bears benchmarks. The empirical evaluation shows that ODS is able to correctly classify 71.9 percent of program repair patches from 26 projects, which improves the state-of-the-art. ODS is applicable in practice and can be employed as a post-processing procedure to classify the patches generated by different APR systems.
Deletion of the middle region of the transcription factor ClrB in Penicillium oxalicum enables cellulase production in the presence of glucose

Enzymes that degrade lignocellulose to simple sugars are of great interest in research and for biotechnology because of their role in converting plant biomass to fuels and chemicals. The synthesis of cellulolytic enzymes in filamentous fungi is tightly regulated at the transcriptional level, with the transcriptional activator ClrB/CLR-2 playing a critical role in many species. In Penicillium oxalicum, clrB overexpression could not relieve the dependence of cellulase expression on cellulose as an inducer, suggesting that clrB is controlled post-transcriptionally. In this study, using a reporter gene system in yeast, we identified the C-terminal region of ClrB/CLR-2 as a transcriptional activation domain. Expression of clrBID, encoding a ClrB derivative in which the DNA-binding and transcriptional activation domains are fused together to remove the middle region, led to cellulase production in the absence of cellulose in P. oxalicum. Strikingly, the clrBID-expressing strain produced cellulase on carbon sources that normally repress cellulase expression, including glucose and glycerol. Results from deletion of the carbon catabolite repressor gene creA in the clrBID-expressing strain suggested that the effect of clrBID is independent of CreA's repressive function. A similar modification of clrB in Aspergillus niger resulted in the production of a mannanase in glucose medium. Taken together, these results indicate that ClrB suppression under noninducing conditions involves its middle region, suggesting a potential strategy to engineer fungal strains for improved cellulase production on commonly used carbon sources.
Experimental Characterization of Polymer Surfaces Subject to Corona Discharges in Controlled Atmospheres

Polymeric dielectrics are employed extensively in the power transmission industry, thanks to their excellent properties; however, under normal operating conditions these materials tend to degrade and fail. In this study, samples of low-density polyethylene, polypropylene, polymethyl methacrylate, and polytetrafluorethylene were subjected to corona discharges under nitrogen and air atmospheres. The discharges introduced structural modifications over the polymer surface. From a chemical perspective, the alterations are analogous among the non-fluorinated polymers (i.e., polyethylene (PE), polypropylene (PP), and polymethyl methacrylate (PMMA)). A simulation of the corona discharge allowed the identification of highly reactive species in the proximity of the surface. The results are consistent with the degradation of insulating polymers in high-voltage applications due to internal partial discharges that ultimately lead to the breakdown of the material.
Debriefing for cardiac arrest

Early data from North America supports the use of educational cardiac arrest debriefing as a strategy to improve the quality of cardiopulmonary resuscitation (CPR) in the hospital setting. As some debriefing approaches are challenging to deliver in the NHS setting, there was a need to develop debriefing approaches that are both effective and suited to NHS working practices. This thesis is modelled on the Medical Research Council framework for the development and evaluation of complex interventions. Undertaken between October 2011 and January 2015, it describes the development and feasibility assessment of three cardiac arrest debriefing approaches, which were specifically designed to be deliverable in NHS hospitals. Development work comprised three work packages (systematic review, process evaluation, qualitative study). These studies provided evidence to support the use of cardiac arrest debriefing, but showed that weekly group debriefing is undeliverable in many NHS hospitals. Through qualitative work, I identified six distinct mechanisms by which debriefing may affect clinical practice. Synthesis of these data led to the development of three cardiac arrest debriefing approaches (monthly group debriefing, individual oral debriefing, written feedback). We tested the feasibility of delivering these interventions by implementing them in three NHS hospitals (one intervention per hospital). In a before/after study, it was demonstrated that, despite practical challenges, interventions were deliverable in NHS hospitals. However, they were found to have no effect on either CPR quality or patient outcome. This finding was attributed to high performance in study hospitals at baseline. This thesis demonstrates that the developed cardiac arrest debriefing interventions are deliverable in NHS hospitals. It has also generated important new theory about the mechanisms by which debriefing may affect clinical practice. This thesis lays the foundation for future work to evaluate the clinical and cost-effectiveness of these cardiac arrest debriefing interventions.
The foraging ecology of male and female squirrel monkeys (Saimiri collinsi) in Eastern Amazonia, Brazil

Sex di erences in foraging behaviors of wild primates may be caused by sex di erences in energetic requirements due to reproduction, body size or by di erences in social behaviors. I investigated the feeding ecology of squirrel monkeys (Saimiri collinsi) in Eastern Amazonia during a 12 month period. Sex di erences in behavior were investigated in relation to seasonal changes in food availability and reproductive events. e wet season corresponded to birth and lactation and the dry season corresponded to mating and gestation. Data were collected on adult males and females in two groups of squirrel monkeys using focal animal samples and intensive sampling of foraging bouts. Insects were the most common dietary item for both sexes (76% of feeding time), followed by the mesocarp of the palm Attalea maripa (28% of plant-feeding time). Sex di erences in activity budgets and foraging success were signi cant throughout the year. Females ate more than males in the wet season. In the dry season, females foraged signi cantly more than adult males but did not eat more. Males were signi cantly more e cient at obtaining insects (0.72 captures/ attempts vs. 0.35 for females). No di erences existed in palm feeding rates. During fruit foraging, however, females stayed in closest proximity to other females and juveniles, whereas adult males foraged alone. ese sex di erences in foraging are best explained by di ering reproductive investment of males and females, and by the female-dominant social structure of Saimiri troops. Resumo Ecologia alimentar de macacos-de-cheiro machos e fêmeas (Saimiri collinsi) na Amazonia Oriental, Brasil Diferenças sexuais na ecologia alimentar de primatas podem ser causadas por diferenças em requerimentos energéticos referentes à reprodução, ao tamanho corporal ou a diferenças em comportamentos sociais de machos e fêmeas. Neste estudo, investiguei a ecologia alimentar de macacos-de-cheiro (Saimiri collinsi) na Amazônia Oriental durante um período de 12 meses. As diferenças comportamentais entre os sexos foram investigadas em relação a mudanças na disponibilidade de recursos alimentares e aos eventos reprodutivos. O comportamento de machos e fêmeas adultos de dois grupos sociais foi estudado pelo método animal-focal e em amostras intensivas de sessões de forrageio. O item mais comum na dieta de ambos os sexos foram insetos (76% do tempo
Boundary Layer Flow of a Nanofluid and Heat Transfer over an Exponentially Shrinking Sheet: Copper-Water

An analysis is carried out to investigate the steady two-dimensional boundary layer flow of a nanofluid and heat transfer over an exponentially shrinking sheet in a water-based copper (Cu). The model used for the nanofluid incorporates the effect of the nanoparticles volume fraction. The governing partial differential equations are converted into a system of nonlinear ordinary differential equations using a similarity transformation, before being solved numerically by using a shooting method. Results for the skin friction coefficient, local Nusselt number, velocity as well as the temperature are presented for different values of the governing parameters. It is found that when the mass suction parameters exceeds a certain critical value, steady flow is possible. Dual solutions for the velocity and temperature distributions are obtained. With increasing values of the nanoparticles volume fraction, the skin friction and heat transfer coefficient increase. Key-Words: Boundary layer, Exponentially shrinking sheet, Heat transfer, Dual solutions, Nanofluid
QUANTITATION AND HPLC IDENTIFICATION OF FLAVONOIDS AND PHENOLICS OF FICUS RACEMOSA (L.) BUTANOL FRACTION AND IN VIVO ASSESSMENT OF ITS HYPOLIPIDEMIC AND HEPATOPROTECTIVE ACTIVITIES IN RATS

Ficus racemosa Linn. belongs to family Moraceae is used as herbal medicine from ancient times. Total phenolic and flavonoid contents of the dried powdered leaves were quantitated and exhibited 15.17% and 18.72%, respectively. Moreover, different extracts; (Distilled water, 70% ethanol and 95% ethanol) of F. racemosa (L.) leaves had been In Vitro assessed as antioxidants. The 95% ethanolic extract gave promising result, consequently, it was fractionated by solvents of increasing polarity and each fraction was screened as well. The butanol fraction was the most bioactive fraction (98.40%). High Performance Liquid Chromatography (HPLC) was used to identify and quantify the flavonoids and phenolics present in it. Further In Vivo assessment against Hyercholesterelemia and liver fibrosis in rats had been done. The butanol fraction exhibited higher antioxidant, hepatoprotective and hypocholesterolemia activities than the standard drugs. These observations were confirmed by the histopathological observation.
Interactive comment on “A Lagrangian view of convective sources for transport of air across the Tropical Tropopause Layer: distribution, times and the radiative influence of clouds” by A. Tzella and B. Legras

The paper by A. Tzella and B. Legras presents a diabatic back trajectory study for transport across the Tropical Tropopause Layer (TTL) from the point of detrainment from deep tropical convection into the upper TTL. Main results are the distribution of convective sources for tropical upward transport and its seasonal dependence and degree of localisation, as well as time-scales for transport. The paper is well written and makes a valuable contribution to research in this key region of the atmosphere, improving our understanding of the interaction of high-reaching tropospheric convection with the upwelling branch of the stratospheric Brewer-Dobson (BD) circulation.
An Axiomatic Account of Similarity

Although computing similarity is one of the fundamental challenges of Information Access tasks, the notion of similarity is not yet completely understood from a formal, axiomatic perspective. In this paper we show how axiomatic explanations of similarity from other fields (i.e. Tversky’s axioms from the point of view of cognitive sciences, and metric spaces from the point of view of algebra) do not completely fit the problem of similarity in Information Access, and we propose a new set of axioms which can be synthesized into a single Similarity Information Monotonicity axiom (SIM). Directly grounded on SIM, we then introduce a new similarity model, the Information Contrast Model, which generalizes both Tversky’s linear contrast model and Pointwise Mutual Information, and, unlike previous similarity models, satisfies the SIM axiom for a certain range of values of its parameters.
Public ownership, entry regulation and TFP growth within a productivity convergence model: Industry level evidence from south European countries

In this paper, we investigate whether the degree of entry liberalization and public ownership is associated with higher industry level total factor productivity (TFP) growth of south European economies. We first estimate relative TFP levels and TFP growth rates across manufacturing and service industries of Greece, Italy and Spain, by using a standard growth accounting framework. Then, we estimate the TFP growth impact of entry liberalization and degree of public ownership, within a productivity convergence framework. To this end, we employ panel data econometric techniques. The empirical results indicate that a higher degree of entry regulation and public ownership is significantly associated with lower TFP growth only for Spanish industries. The empirical results for Italy and Greece do not provide us with any evidence for a statistically significant impact of these variables on TFP growth. We attribute the mixed nature of our results to the fact that south European economies still operate below the productivity frontier and are still considered as relatively more
Mechanical and Physical Properties of Polyester Reinforced Glass Fibre/Orange Peel Particulate Hybrid Composite

This study was focused on the development of hybrid composed using orange peel particulate dispersed in an unsaturated polyester resin reinforced with chopped strands of E-glass fibers. Orange peel particulate of about 350µm sieve size, of varying weight percentage (3, 6, 9,12 and 15) wt. % and E-glass fiber of constant weight percentage 25.1wt% was used as reinforcements in a polyester matrix. The effect of the orange peel particulate on the physical and mechanical properties of the resulting composite such as tensile strength, bending strength, impact strength and hardness strength was investigated. The results showed remarkable improvement in mechanical properties with increase in percentage of particulate reinforcement. Tensile strength varies from 50.0 to 62.6 MPa, Hardness values varies between 28.6 and 40.8HRB, Impact energy at room temperature, varies between 5.0 to 7.4 Joules, as a function of fiber weight fractions and the flexural strength varies from 74.0 to 85.2 MPa. The best mechanical properties were obtained at 15 Wt. % particulate reinforcements. The results of the physical tests show that the water absorption increases as the weight percentage of the particulate reinforcement increases and the same condition also holds for the density.
Gluten-free cheese bread from frozen dough: effect of modified cassava starch

Gluten-free (GF) cheese bread is very popular in some countries of South America (Colombia and Brazil) and is marketed in United States, England, Otaly, Portugal, Spain, Argentina and Paraguay (Rodriguez-Sandoval et al., 2014; Silva et al., 2017). GF cheese bread is made by mixing cheese with modified cassava starch, water or milk, salt, sugar and fat. This product is not undergone yeast fermentation before baking, and it is baked immediately once the dough is made. Ots rise while baking does not imply a protein-gluten network or the production of carbon dioxide by yeast (Rodriguez-Sandoval et al., 2014). The dough expansion of the GF cheese bread while baking involves the formation of a foam structure with separate gas cells within a sponge structure with interconnected (Bertolini et al., 2001). Thus, this GF product has a spongy texture and low density. The shelf-life of GF cheese bread is short (less than 3 days) due to its physical and sensory properties, especially its rapid increase in hardness (López-Tenorio et al., 2015).
Short- and long-term results after surgical treatment of an ununited anconeal process in the dog

Summary In a prospective trial over seven years (1993-1999), 44 joints from 41 dogs with an ununited anconeal process are reported. The average age of the animals was 23 weeks. With regard to breed distribution, the German Shepherd was most frequently represented with 29 animals. In 35 joints, the anconeal process was stabilised with lag screw and pin, as there was no fibrous connection between the anconeal process and the ulna. Additionally, in all cases an ulna ostectomy was performed. In nine joints, the connection of the anconeal process to the olecranon was firm and only a proximal ulna ostectomy was performed. The patients were rechecked clinically and radiologically, at an average of 13 weeks post operation. With one exception, in all of the cases the apophysis was closed. The implants were removed in 25 patients. The surgical results were examined once more after an average of 20 months in 43 joints (40 dogs). 83.7% of the cases (n = 36) did not show any lameness after the combined therapy with fixation of the isolated anconeal process and osteotomy of the ulna (n = 28) or ulna ostectomy only (n = 8) and were assessed as ‘good’. Six dogs (five with fixation, one with ostectomy) showed some degree of lameness after heavy strain and were only evaluated as ‘satisfactory’. One dog still had a striking low to medium grade lameness, so that the result was regarded as ‘unsatisfactory’. With regard to the development of arthrosis, only nine of the 30 joints (30%) examined radiographically showed a mild increase of the arthroses during later examinations. In many cases excision of the ununited anconeal process leads to unsatisfactory long-term results. Frequently surgical treatment does not lead to fusion. This paper describes a concept for treatment of an ununited anconeal process and the short- and long-term results. Proximal ostectomy of the ulna was performed, as a single measure, when the anconeal process was tightly in place. In joints with a loose anconeal process, the piece of bone was stabilised with implants, in addition to an ostectomy of the ulna. After an average of three months, the anconeal process had fused with the ulna, in all hut one case. In long-term follow-ups, after an average of 20 months, most of the dogs did not show any lameness, even after exercise. In only a few joints was a minor increase of arthrosis noted. The technique described is considered to be useful to treat the ununited anconeal process in young dogs.
The Effect of Female Health Volunteers Education on knowledge and Attitude of Urban Population about Mental Health in Isfahan province

Introduction: One of the challenges of medical universities is to deliver medical and health instructions and the related concepts from the higher university levels to the basic levels of the society. The absolute need to have a communicating bridge between the universities and the urban society, has led to more attention to community health volunteers as the potential source for such a link. This study attempted to determine the effect of female health volunteer education on the knowledge and attitude towards mental health in urban
3 D ec 2 01 4 Hamiltonian chordal graphs are not cycle extendable

In 1990, Hendry conjectured that every Hamiltonian chordal graph is cycle extendable; that is, the vertices of any non-Hamiltonian cycle are contained in a cycle of length one greater. We disprove this conjecture by constructing counterexamples on n vertices for any n ≥ 15. Furthermore, we show that there exist counterexamples where the ratio of the length of a non-extendable cycle to the total number of vertices can be made arbitrarily small. We then consider cycle extendability in Hamiltonian chordal graphs where certain induced subgraphs are forbidden, notably Pn and the bull.