Miracle-dz/UniFAR-FTUs huggingface dataset:
Presence of the Metabolic Syndrome in Obese Children at Prepubertal Age

Background/Aims: There is a strong debate on the diagnosis and early phenotypic expression of the metabolic syndrome in children. The aim of the present study was to examine the frequency of the metabolic syndrome using various definitions in obese prepubertal and pubertal children. Methods: 478 (213 females and 265 males) obese children were recruited in three provinces of Spain. Blood pressure (BP), waist circumference, and weight and height were measured, and body mass index was calculated. Glucose, insulin, high-density lipoprotein cholesterol and triacylglycerols were determined. We classified the children according to seven different proposed definitions of the metabolic syndrome. Results: Regardless of the definition used, the prevalence of the metabolic syndrome (8.3–34.2%) was relatively high in obese children in the prepubertal period as well as in pubertal children (9.7–41.2%). We performed a principal-factor analysis to explain correlations among features of the metabolic syndrome and found that glucose metabolism (factor 1), dyslipidemia (factor 2) and obesity/BP (factor 3) explained 72% of the total variance. Conclusion: Irrespective of the classification used, the metabolic syndrome is not only present in pubertal but also in prepubertal children. International definitions of the metabolic syndrome should also consider criteria specific for children in the prepubertal period, i.e. children aged <10 years.
Pro-Competitive Effect of Trade and Non-Decreasing Price-Cost Margins

This study surveys the empirical evidence on the pro-competitive effect of international trade and analyses the determinants of price-cost margins for OECD countries between 1970 and 2003. The main objective was to focus on the quantification of the impact of imports on margins, and understand why, despite trade liberalization, price-cost margins have not fallen overall. On average, imports would have contributed to a large decrease of five percentage points in the price-cost margins. However, these effects seem to have been partially counterbalanced by the impacts of financial deepening and disinflation.
What is in a surname? The role of ethnicity in economic decision making

This article reports results from two experiments that investigate possible incidence of discrimination against people with foreign backgrounds in Sweden. In the first experiment, participants played the trust game and the dictator game with co-players of different ethnic affiliation. The family name of the players was exposed to their co-players. Results for the trust game showed no significant discrimination against co-players with foreign backgrounds. On the other hand, the results for the dictator game showed a statistically significant discriminatory behaviour by men against co-players with non-European backgrounds. The discriminatory behaviour was solely a male phenomenon. In the second experiment, the dictator game was replicated to check the stability of the results in the first experiment. The second experiment also examined whether people with foreign backgrounds discriminate against other people with foreign backgrounds; that is, the purpose was to discover whether discrimination is systematic. The observations in the second experiment underlined the results found in the first experiment: foreign co-players are discriminated against by Swedish players. However, we did not find that people with foreign backgrounds discriminated against other people with foreign backgrounds.
The impact of trading commission incentives on analysts' stock coverage decisions and earnings forecasts

In this paper, I consider how security analysts' incentives to generate trading commissions affect the accuracy and availability of their reports. I model the interaction between an analyst and an investor who holds an initial endowment of a risky asset and must pay a commission to a brokerage firm in order to buy or sell shares of the asset. The investor bases his decision on information provided by the analyst, who is in turn employed by the brokerage. The analyst's decision about how much information to gather about the asset is driven by his expectations of the commissions to be generated from that information. I find that the analyst's incentives to gather information are strongest for stocks that are expected to perform well; consequently, reports (i.e., forecasts) for these stocks are likely to be more accurate than forecasts
Hybrid memory cube new DRAM architecture increases density and performance

Multi-core processor performance is limited by memory system bandwidth. The Hybrid Memory Cube is a three-dimensional DRAM architecture that improves latency, bandwidth, power and density. Through-silicon vias (TSVs), 3D packaging and advanced CMOS performance enable a new approach to memory system architecture. Heterogeneous die are stacked with significantly more connections, thereby reducing the distance signals travel.
‘Greening’ the 2010 FIFA World Cup: Environmental Sustainability and the Mega-Event in South Africa

Event greening of major spectacles such as the Olympics, World Cups and large international conferences are increasingly common. The 2010 South African World Cup sought to develop a ‘Green Goal 2010’ programme that would mitigate some of the environmental impacts of the event, as well as secure a positive social, economic and environmental legacy. While the content of the Green Goal programmes varied between host cities, some innovative and significant projects were implemented, ranging from waste management and recycling, to biodiversity protection and city beautification, to public transport upgrades and energy efficiency measures at the stadiums. In the broader context of the most carbon-intensive World Cup ever, however, such mitigation efforts were relatively piecemeal. The greatest opportunity the World Cup provided was for its visibility, branding and communication potential to catalyse greater environmental awareness and a stronger commitment to ecological modernization. Due to lack of coordination and national leadership, this opportunity was largely missed. The article concludes by recommending a number of core lessons, as well as some further opportunities, that can be taken from the South African 2010 experience.
Trading with Asymmetric Volatility Spillovers

We study the profitability of trading strategies based on volatility spillovers between large and small firms. By using the Volatility Impulse-Response Function of Lin (1997) and its extensions, we detect that any volatility shock coming from small companies is important to large companies, but the reverse is only true for negative shocks coming from large firms. To exploit these asymmetric patterns in volatility, different trading rules are designed based on the inverse relationship existing between expected return and volatility. We find that most strategies generate excess after-transaction cost profits, especially after "very bad news" and "very good news" coming from large or small firm markets. These results are of special interest because of their implications for risk and portfolio management. Copyright 2007 The Authors Journal compilation (c) 2007 Blackwell Publishing Ltd.
Escitalopram in the treatment of major depressive disorder: a meta-analysis.

OBJECTIVE To assess the relative antidepressant efficacy of escitalopram and comparator antidepressants. RESEARCH DESIGN AND METHODS A meta-analysis was performed using studies in major depressive disorder (MDD) comparing escitalopram with active controls, including selective serotonin reuptake inhibitors [SSRIs] (citalopram, fluoxetine, paroxetine, sertraline) and serotonin/noradrenaline reuptake inhibitors [SNRIs] (venlafaxine, duloxetine). Adult patients had to meet DSM-IV criteria for MDD. MAIN OUTCOME MEASURES The primary outcome measure was the treatment difference in Montgomery-Asberg Depression Rating Scale (MADRS) total score at week 8. Secondary outcome measures were response and remission (MADRS total score < or = 12) rates. RESULTS Individual patient data (N = 4549) from 16 randomized controlled trials were included in the analyses (escitalopram n = 2272, SSRIs n = 1750, SNRIs n = 527). Escitalopram was significantly more effective than comparators in overall treatment effect, with an estimated mean treatment difference of 1.1 points on the MADRS (p < 0.0001), and in responder (63.7 vs. 58.3%, p < 0.0001) and remitter (53.1 vs. 49.4%, p < 0.0059) analyses. Escitalopram was significantly superior to SSRIs, with an estimated difference in response of 62.1 vs. 58.4% and remission of 51.6 vs. 49.0%. In comparison to SNRIs, the estimated difference in response was 68.3 vs. 59.0% (p = 0.0007) and for remission the difference was 57.8 vs. 50.5% (p = 0.0088). These results were similar for severely depressed patients (baseline MADRS > or = 30). Sensitivity analyses were performed with data from articles reporting Hamilton Rating Scale for Depression (HAMD) scores. The 8-week withdrawal rate due to adverse events was 5.4% for escitalopram and 7.9% for the comparators (p < 0.01). This difference was accounted for by statistically significant higher attrition rates in the SNRI comparisons. This work may be limited by the clinical methodology underlying meta-analytic studies, in particular, the exclusion of trials that fail to meet predetermined criteria for inclusion. CONCLUSIONS In this meta-analysis, superior efficacy of escitalopram compared to SSRIs and SNRIs was confirmed, although the superiority over SSRIs was largely explained by differences between escitalopram and citalopram.
Conformational Differences between Two Amyloid β Oligomers of Similar Size and Dissimilar Toxicity*

Background: The Alzheimer Aβ peptide assembles into multiple small oligomers that are cytotoxic. Results: Increased solvent exposure of hydrophobic residues within non-fibrillar Aβ oligomers of similar size increases cytotoxicity. Conclusion: Aβ non-fibrillar oligomers display size-independent differences in toxicity that are strongly influenced by oligomer conformation. Significance: Identifying the conformational determinants of Aβ-mediated toxicity is critical to understand and treat Alzheimer disease. Several protein conformational disorders (Parkinson and prion diseases) are linked to aberrant folding of proteins into prefibrillar oligomers and amyloid fibrils. Although prefibrillar oligomers are more toxic than their fibrillar counterparts, it is difficult to decouple the origin of their dissimilar toxicity because oligomers and fibrils differ both in terms of structure and size. Here we report the characterization of two oligomers of the 42-residue amyloid β (Aβ42) peptide associated with Alzheimer disease that possess similar size and dissimilar toxicity. We find that Aβ42 spontaneously forms prefibrillar oligomers at Aβ concentrations below 30 μm in the absence of agitation, whereas higher Aβ concentrations lead to rapid formation of fibrils. Interestingly, Aβ prefibrillar oligomers do not convert into fibrils under quiescent assembly conditions but instead convert into a second type of oligomer with size and morphology similar to those of Aβ prefibrillar oligomers. Strikingly, this alternative Aβ oligomer is non-toxic to mammalian cells relative to Aβ monomer. We find that two hydrophobic peptide segments within Aβ (residues 16–22 and 30–42) are more solvent-exposed in the more toxic Aβ oligomer. The less toxic oligomer is devoid of β-sheet structure, insoluble, and non-immunoreactive with oligomer- and fibril-specific antibodies. Moreover, the less toxic oligomer is incapable of disrupting lipid bilayers, in contrast to its more toxic oligomeric counterpart. Our results suggest that the ability of non-fibrillar Aβ oligomers to interact with and disrupt cellular membranes is linked to the degree of solvent exposure of their central and C-terminal hydrophobic peptide segments.
Theory of Planned Behavior: Potential Travelers from China

Tourist behavior theories have been the focus of research in many tourism studies, but how travelers’ behavioral intention in choosing a travel destination is developed has rarely been investigated. This study tested the fit of the theory of planned behavior (TPB) with potential travelers from Mainland China to Hong Kong as the sample (n = 328). Results showed that data fitted the TPB model moderately well and explained respondents’traveling intention. Attitude, perceived behavioral control, and past behavior were found to be related to respondents’travel intention. Recommendations were provided for government and tourism bodies to market Hong Kong as a destination for Mainland Chinese travelers.
‘O convergence, where art thou?’ Regional growth and industrialization in Italy 1

Abstract This paper shows that the Italian economy has two long-run equilibria, which are due to the different level of industrialization between the centre-north and the south of the country. These equilibria converge until 1971 but diverge afterwards; the end of the convergence process coincides with the slowing down of Italy's industrialization policy in the South. In this paper we argue that to address this problem effectively, an economic policy completely different from that in place in needed. However, such a policy is unlikely to be implemented given the scarcity of resources and the short run nature of the political cycle.
A function for live weight change between two calvings in dairy cattle

A function to describe live-weight changes of dairy cows between two calvings is constructed. The following measurements were used: live-weight level (scale), pregnancy parameter, maximum decrease of live weight during the lactation and the time during lactation at which minimum live weight occurred. An analysis was carried out for each of 71 dairy cows of two genotypes, Dutch Friesian and Holstein Friesian crossbreds, given a high or a low concentrate diet. Data set 1 contained data of 40 weeks lactation and data set 2 data from calving to calving. The mean residual standard deviation per genotype-diet group ranged from 11 to 14 kg. The mean R2 ranged over the subgroups in data set 1 from 0·715 to 0·792 and in data set 2 from 0·857 to 0·906. Diet had a significant influence on the magnitude of the decrease in live weight during the lactation (71 v. 46 kg) and the mean time during the lactation at which minimum live weight occurred. The latter time ranged from day 58 to 100 over the four groups and a diet effect existed. The pregnancy parameter could not be estimated accurately based on measurements during the first 40 weeks of lactation. The correlation coefficient between the pregnancy parameter in data sets 1 and 2 ranged from +0·13 to +0·78. The other parameters showed coefficients from +0·82 to +0·99.
Comparison of Short Questionnaires on Alcohol Drinking Behavior in a Nonclinical Population of 36-Year-Old Men and Women

Little is known on the diagnostic characteristics of brief questionnaires on alcohol drinking behaviors. This report investigates the determinants of three short alcohol questionnaires and investigates their diagnostic utility as screening tools for alcohol-related problems in a general population from The Netherlands. This report uses cross-sectional data obtained in the year 2000 from 36-year-old healthy male (N = 166) and female (N = 165) volunteers who reported to drink alcohol at least occasionally. Since they were 13-years-old these volunteers have been members of the Amsterdam Growth And Health Longitudinal Study, which started as a school-based study in 1977. Among many other variables, quantity–frequency questions (QF), the CAGE questionnaire, and a question on the highest number of alcoholic units consumed on one occasion during the previous month (MAX) were asked. The sensitivity, specificity, Cohen's kappa, and diagnostic odds ratio of QF, CAGE, MAX, and combinations of these three brief questionnaires were calculated using a 7-item questionnaire on alcohol-related problems as reference. Both in women and men, the prevalence of most alcohol-related problems and of a high QF, CAGE, and MAX was low. QF, CAGE, and MAX, as well as all possible combinations of the three questionnaires, were poor in detecting last-year alcohol-related problems. The CAGE appeared to perform worse than the even shorter and easier-to-interpret QF and MAX. In this healthy population of 36-year-old men and women, using the QF, MAX, and especially the CAGE questionnaire as screening instruments for alcohol-related problems resulted in many false positive and false negative classifications.
History of Astroparticle Physics and its Components

This article gives an outline of the historical events that led to the formation of contemporary astroparticle physics. As a starting point for analyzing the history of astroparticle physics this article will review the various, yet scattered pieces of historical work that have been done so far. To make the picture more complete it will then give a brief survey of the most important fields that have played a role in the development of astroparticle physics as we know it today. It will conclude with an overview of the historical questions that are still open and the rich philosophical implications that lie behind those questions.
Stable transfection of the human parasite Leishmania major delineates a 30-kilobase region sufficient for extrachromosomal replication and expression

To delineate segments of the genome of the human protozoan parasite Leishmania major necessary for replication and expression, we developed a vector (pR-NEO) which can be reproducibly introduced into L. major. This DNA was derived from a 30-kilobase extrachromosomal amplified DNA bearing the dihydrofolate reductase-thymidylate synthase gene, with the coding region for neomycin phosphotransferase substituted for that of dihydrofolate reductase-thymidylate synthase and a bacterial origin of replication and selectable marker added. G418-resistant lines were obtained at high efficiency by electroporation of pR-NEO (approaching 10(-4) per cell), while constructs bearing an inverted neo gene or lacking Leishmania sequences did not confer resistance. pR-NEO replicated in L. major and gave rise to correctly processed transcripts bearing the trans-spliced miniexon. Molecular karyotype analysis showed that in some lines pR-NEO DNA exists exclusively as an extrachromosomal circle, a finding supported by the rescue of intact pR-NEO after transformation of Escherichia coli. These data genetically localize all elements required in cis for DNA replication, transcription, and trans splicing to the Leishmania DNA contained within pR-NEO DNA and signal the advent of stable transfection methodology for addressing molecular phenomena in trypanosomatid parasites.
Teacher Evaluation as Policy Target: Viable Reform Venue or Just Another Tap Dance?

In this No Child Left Behind era of renewed emphasis on the search for the “highly qualified” teacher, governors, legislators, and state department of education officials have an incentive to focus on improving teacher quality through teacher evaluation. While teacher evaluation practices have been traditionally problematic “based on procedural reviews and infrequent classroom observation by often untrained and overtaxed school administrators,” (Goldrick, 2002, p. 2) some hope that recent efforts will “revolutionize” and “transform” the ways evaluation is conducted, and thus, be linked to student achievement (The Commission for No Child Left Behind, 2007).
Vaccinia virus E3L protein is an inhibitor of the interferon (i.f.n.)-induced 2-5A synthetase enzyme.

Induction of apoptosis in mammalian cells by double-stranded (ds) RNA-dependent enzymes, protein kinase (PKR), and 2-5A-synthetase/RNase L (referred to as the 2-5A system) might be a mechanism mediating anticellular and antiviral actions of interferon (i.f.n.). To counteract the effect of i.f. n. , animal viruses have acquired genes that block specific i.f. n. pathways. Among poxviruses, vaccinia virus (VV) encodes E3L, a dsRNA-binding protein, which inhibits activation of i.f. n. -induced PKR. It has been proposed that E3L might also block activation of the 2-5A system, but direct proof is lacking. To establish if E3L inhibits the 2-5A system, we have developed a method to assay apoptosis induced by increased production of enzymes in the 2-5A pathway, as well as of their putative modulators. This assay is based on the use of cells derived from homozygous PKR knockout mice (Pkr-/-) infected with a VV mutant lacking E3L (delta E3L) and transiently transfected with a luciferase reporter gene together with plasmid vectors expressing 2-5A-synthetase, RNase L, or E3L, all controlled by the same inducible promoter. We found that expression of 2-5A-synthetase inhibited luciferase activity in a dose-response manner, reaching inhibition values of 80% relative to transfections with control plasmids. Similar results were obtained by transfection with an RNase L vector, although in this case the extent of inhibition was further enhanced upon coexpression of 2-5A-synthetase and RNase L. Inhibition of protein synthesis mediated by the 2-5A system correlated well with induction of apoptosis. Transfection of cells with a plasmid vector expressing E3L together with 2-5A-synthetase completely prevented apoptosis induced by this enzyme. We conclude that VV E3L acts as an inhibitor of the i.f. n. -induced 2-5A-synthetase enzyme.
Household responses to public health services : cost and quality tradeoffs

The effectiveness of government investments in health care depends on the public's response to price and quality as well as on whether these expenditures actually improve health outcomes. Consumers, even those in low-income households, are willing to pay fees for better health care if the fees translate into improved access and reliability. But when prices rise without a concomitant improvement in services, malnutrition and child mortality rates increase. The availability of basic health care has a relatively greater impact on households with low incomes or low education, or both, than does the provision of more specialized services. This article describes the types of services for which households indicate they are willing to pay increased fees. It also indicates the potential gains from improving these services, as well as the consequences of moving faster on cost recovery than on providing improved or better-targeted services. Copyright 1996 by Oxford University Press.
Party Systems and Government Stability in Central and Eastern Europe

After two decades of parliamentary democracy, the countries of Central and Eastern Europe (CEE) have quite different records of government stability. At the same time there continues to be turbulent fluctuation within the individual countries. To explain this variation, the authors draw on characteristics of parties and party systems for 138 governments in 12 CEE countries. The analysis is structured by two distinct logics that underlie the effect of party-related attributes on government survival: the logic of internal friction within the government and the logic of external pressure from the opposition. The authors argue that in the "difficult" contexts of postcommunist party systems, these two logics do not operate independently of each other. Instead, they suggest that standard theory needs to be revised to account for the interactions of government and opposition characteristics. Their model of these interactions not only includes standard numeric and ideological variables but also integrates specificities of the postcommunist context: the regime divide and the low degree of party-system consolidation. Quantitative and qualitative findings demonstrate that government stability in CEE is interactively determined by whole constellations of party attributes.