Miracle-dz/UniFAR-FTUs huggingface dataset:
Serum electrolyte imbalance and prognostic factors of postoperative death in adult traumatic brain injury patients

Abstract Electrolyte imbalances are common in traumatic brain injury. It shares the cause of perioperative morbidity and mortality. Types of intravenous fluid resuscitation, osmotic diuretics, massive blood loss, and intracranial pathology were considered as the potential factors to worsen electrolyte abnormalities in these patients. The aims of this study were to report the incidence of electrolyte imbalance in traumatic brain injured patients and to assess the association between electrolyte imbalance and other prognostic factors to death within 24 hours of the injury. The study was carried out in the northern university, tertiary-care hospital of Thailand. The patients aged from 18 to 65 years old, presented with traumatic brain injury, and needed for emergency craniotomy were included. We excluded the patients who had minor neurosurgical procedures, pregnancy, and undergone cardiopulmonary resuscitation from the Emergency Department. Among 145 patients recruited, 101 (70%) had Glasgow Coma Scale (GCS) score ⩽ 8, 25 (17%) had GCS score 9 to 12, and 19 (13%) had GCS score 13 to 15. The most common diagnosis were subdural hematoma and epidural hematoma, 51% and 36%, respectively. Hypokalemia was the most common electrolyte imbalance at 65.5%. The results of the use of a multivariable logistic regression model show that the odds of postoperative death in TBI patients were increased with high levels of blood glucose, hypernatremia, and acidosis. Hypokalemia was the most common electrolyte imbalance in TBI patients. Hypernatremia, acidosis, and hyperglycemia significantly increased the odds ratio of death in the first 24 hours post TBI.
Successful Aging in Colombia: The Role of Disease

Objective: This study aimed to determine the prevalence of successful aging (SA) and identify its predictive factors in a cohort of older people in the Colombian Andes Mountain. Method: Data were drawn from a prospective longitudinal study of community-dwelling elderly people in Manizales. SA encompassed indicators in four domains: physical, cognitive, emotional, and social functioning. Results: The prevalence of SA was 24.4%. The independent predictors were good and very good self-rated health, middle–high/high-income level, absence of chronic conditions, married status, high educational level, and very high spirituality. Discussion: The prevalence of SA was low: One of 10 people older than 65 years showed SA when presence of diseases was included in the criteria, compared with one of four when such an item was excluded. The identification of predictive factors allows distinguishing this population in primary care services and promoting strategies that ensure high functionality levels for as long as possible.
Structured Turbo Compressed Sensing for Downlink Massive MIMO-OFDM Channel Estimation

Compressed sensing has been employed to reduce the pilot overhead for channel estimation in wireless communication systems. Particularly, structured turbo compressed sensing (STCS) provides a generic framework for structured sparse signal recovery with reduced computational complexity and storage requirement. In this paper, we consider the problem of massive multiple-input multiple-output (MIMO) orthogonal frequency division multiplexing (OFDM) channel estimation in a frequency division duplexing (FDD) downlink system. By exploiting the structured sparsity in the angle-frequency domain (AFD) and angle-delay domain (ADD) of the massive MIMO-OFDM channel, we represent the channel by using AFD and ADD probability models and design message-passing-based channel estimators under the STCS framework. Several STCS-based algorithms are proposed for massive MIMO-OFDM channel estimation by exploiting the structured sparsity. We show that, compared with other existing algorithms, the proposed algorithms have a much faster convergence speed and achieve competitive error performance under a wide range of simulation settings.
Effects of Maternal and Post-Weaning High-Fat Diet on Leptin Resistance and Hypothalamic Appetite Genes in Sprague Dawley Rat Offspring

The defective satiation signaling may contribute to the etiology of obesity. We investigated how dietary modification during maternal (pregnancy and lactation) and post-weaning affects obesity, insulin resistance (IR) and hypothalamic appetite responses in offspring in adulthood. Pregnant female SD rats were randomly allocated to either maternal high-fat diet (43% energy from fat) or control diet (12% energy from fat) until the end of suckling. After weaning for additional 4 weeks, half of the offsprings were continuously fed the same diet as the dam (C-C and H-H groups); the remainder received the counterpart diet (C-H and H-C groups). The long-term high-fat diet during maternal and post-weaning period (H-H group) led to susceptibility to obesity and IR through the significant increases of hypothalamic orexigenic genes compared to the maternal and post-weaning control diet group (C-C group). In contrast, the hypothalamic expression levels of anorexigenic genes, apolipoprotein E, leptin receptor, and activated signal transducer and activator of transcription protein 3 were significantly lower in H-H group with elevations in circulating insulin and leptin and body fat mass. However, dietary changes after weaning (H-C and C-H groups) partially modified these conditions. These results suggest that maternal and post-weaning diet conditions can potentially disrupt hypothalamic neuronal signal irrelevantly, which is essential for leptin's regulation of energy homeostasis and induce the risk of offspring to future metabolic disorders.
Gestational age‐dependent gene expression profiling of ATP‐binding cassette transporters in the healthy human placenta

The ATP‐binding cassette (ABC) transporters control placental transfer of several nutrients, steroids, immunological factors, chemicals, and drugs at the maternal‐fetal interface. We and others have demonstrated a gestational age‐dependent expression pattern of two ABC transporters, P‐glycoprotein and breast cancer resistance protein throughout pregnancy. However, no reports have comprehensively elucidated the expression pattern of all 50 ABC proteins, comparing first trimester and term human placentae. We hypothesized that placental ABC transporters are expressed in a gestational‐age dependent manner in normal human pregnancy. Using the TaqMan® Human ABC Transporter Array, we assessed the mRNA expression of all 50 ABC transporters in first (first trimester, n = 8) and third trimester (term, n = 12) human placentae and validated the resulting expression of selected ABC transporters using qPCR, Western blot and immunohistochemistry. A distinct gene expression profile of 30 ABC transporters was observed comparing first trimester vs. term placentae. Using individual qPCR in selected genes, we validated the increased expression of ABCA1 (P < 0.01), ABCA6 (P < 0.001), ABCA9 (P < 0.001) and ABCC3 (P < 0.001), as well as the decreased expression of ABCB11 (P < 0.001) and ABCG4 (P < 0.01) with advancing gestation. One important lipid transporter, ABCA6, was selected to correlate protein abundance and characterize tissue localization. ABCA6 exhibited increased protein expression towards term and was predominantly localized to syncytiotrophoblast cells. In conclusion, expression patterns of placental ABC transporters change as a function of gestational age. These changes are likely fundamental to a healthy pregnancy given the critical role that these transporters play in the regulation of steroidogenesis, immunological responses, and placental barrier function and integrity.
Liver Fibrosis Markers Improve Prediction of Outcome in Non‐Acetaminophen‐Associated Acute Liver Failure

A prognostic system for acute liver failure (ALF) with a higher predictive value is urgently needed. The role of extracellular matrix (ECM) remodeling in ALF has not been fully elucidated. We hypothesized that serologic fibrosis markers, which reflect ECM remodeling, are predictive of ALF outcome at first presentation. This observational study included 110 patients with acute liver dysfunction, of which 73 had non‐acetaminophen‐associated ALF (NAA‐ALF). We evaluated serum levels of hyaluronic acid, 7S domain of type IV collagen (4COL7S), and Wisteria floribunda agglutinin‐positive Mac‐2‐binding protein at first presentation to a tertiary center. Serologic fibrosis markers were significantly higher in NAA‐ALF compared with acute hepatitis. Elevated hyaluronic acid and 4COL7S levels at first presentation correlated significantly with worse clinical outcomes. 4COL7S, along with age, ammonia, and the Model for End‐Stage Liver Disease (MELD) score, was a significant prognostic factor in multivariate analysis; 4COL7S correlated significantly with coagulopathy, decreased hepatic synthetic functions, advanced hepatic encephalopathy, and liver atrophy and also predicted 180‐day transplant‐free survival. Cox regression models incorporating 4COL7S with the MELD system had profoundly improved predictive values that significantly surpassed the MELD system alone. Conclusion: Elevation of serologic fibrosis markers reflecting ECM remodeling in NAA‐ALF predicted a worse clinical outcome. Incorporation of 4COL7S at first presentation to a transplant center improves the specificity while retaining the sensitivity of the MELD system. External validation of a fibrosis marker as part of a clinical prediction tool in ALF warrants further investigation.
ORTAOKUL ÖĞRENCİLERİNİN ELEŞTİREL OKUMA ÖZYETERLİKLERİ

Bu arastirmanin amaci ortaokul ogrencilerinin elestirel okuma ozyeterliklerini belirlemektir. Arastirma tarama yontemi ile yapilmistir. Arastirmaya Bartin’da, 3 ortaokulda 5. , 6. , 7. ve 8. siniflarda okuyan 378 ogrenci katilmistir. Veri toplama araci olarak Elestirel Okuma Olcegi kullanilmistir. Arastirma sonucunda ogrencilerin elestirel okuma ozyeterliklerinin orta duzeyde oldugu, cinsiyete gore anlamli fark olmadigi, anne ve baba egitim durumu yuksek olan ogrencilerin lehine ve sinif duzeyine gore 5. siniflar lehine anlamli farklar oldugu gorulmustur. Ayrica aylik gelir, bir yilda okunan ders disi kitap sayisi ve Turkce dersi basari notu ile elestirel okuma ozyeterligi arasinda olumlu yonde anlamli iliskiler belirlenmistir. Arastirmanin en cok dikkat ceken bulgusu 5. siniflarin elestirel okuma ozyeterliginin ust siniflardan fazla olmasidir. Oysa elestirel okuma becerisinin surec icinde gelismesi beklenir. Bu sonuc ogrencilerin ders disi okumalari ilkokulda daha cok yapmalari ve sinif duzeyi arttikca ders disi okumanin azalmasi ile iliskili gorunmektedir. Turkce haftalik ders saatleri azaldikca ogretmenler bilgi aktarimina odaklanmakta ve okumanin niteliginden uzaklasmaktadir. Ogretmenlerin konuyla ilgili yetkinligini artirmak icin hizmet ici egitimler verilmelidir. Ailenin sosyoekonomik durumundan cocuklarin olumsuz etkilenmemesi icin ebeveynlere cocuklara nasil destek olabilecekleri konusunda bilgi verilmelidir.
Closed-Form Solution of Rough Conductor Surface Impedance

This paper presents a closed-form solution of rough conductor surface impedance in terms of material DC conductivity and RMS roughness. Surface roughness is modeled by position-dependent conductivity at conductor-dielectric boundary to account for protrusion of rough conductor into dielectric, which was first proposed in the Gradient model. Analytic solution is obtained by approximating the Gauss cumulative distribution function, used to model the position-dependent conductivity in the Gradient model, with a square of hyperbolic tangent. Closed-form solutions are compared with numerical solutions of the Gradient model and are in good agreement up to a frequency of 100 GHz. Derived surface impedance is causal, which has been shown by numerical Hilbert transform.
DNN-Based Near- and Far-Field Source Separation Using Spherical-Harmonic-Analysis-Based Acoustic Features

We propose the combination of a physical-model-based and a deep-learning (DL)-based source separation for near- and far-field source separation. The DL-based near- and far-field source separation method uses spherical-harmonic-analysis-based acoustic features. Deep learning is a state-of-the-art technique for source separation. In this approach, a deep neural network (D NN) is used to predict a time-frequency (T-F) mask. To accurately predict a T-F mask, it is necessary to use acoustic features that have high mutual information with the oracle T-F mask. However, the effective acoustic features to separate near- and far-field sources are unknown. In this study, low-frequency-band near- and far-field sources are estimated based on spherical harmonic analysis and used as acoustic features. Subsequently, a DNN predicts a T-F mask to separate all frequency bands. Our experimental results show that the proposed method improved the signal-to-distortion-rate by 6–8 dB compared to the harmonic-analysis-based method.
Predictors of mortality in patients with COPD after 9 years

Background COPD is one of the leading causes of morbidity and mortality in the world; however, the most varied amounts of clinical and laboratory characteristics acts in different ways in the mortality among over time. Therefore, this study aimed to evaluate the predictors of mortality in patients with COPD after 9 years. Patients and methods One hundred and thirty-three patients with COPD were assessed at baseline by spirometry, pulse oximetry (SpO2), body composition, intensity of dyspnea, distance walked in the 6-minute walk test (6MWT), and Charlson Comorbidity Index (CCI). Results After 9 years, it was not possible to identify the lifetime of 4 patients who died and of 19 patients who stopped follow-up; thus, 110 patients were included in the analysis of predictors of mortality (67% male, 65±9 years old, and FEV1: 52.5 [40%–73%]). Male sex, age, SpO2, Body mass index, airway Obstruction, Dyspnea, and Exercise capacity (BODE) index, and frequency of exacerbations in the first 3 years of follow-up were considered in the model. Patients classified at baseline with BODE class 2 (HR: 2.62, 95% CI: 1.36–5.04; P=0.004), BODE class 3 (HR: 2.54, 95% CI: 1.15–5.61; P=0.02), and BODE class 4 (HR: 15.35, 95% CI: 3.11–75.75; P=0.001) showed increased risk of death compared to those with BODE class 1. The CCI (HR: 1.29, 95% CI: 1.00–1.68; P=0.04) and the number of exacerbations in the first 3 years (HR: 1.32, 95% CI: 1.00–1.76; P=0.04) also showed increased risk of death. By replacing the BODE index for the variables that compose it, those with body mass index ≤21 kg/m2 showed increased risk of death compared to those with body mass index (BMI)>21 kg/m2 (HR: 2.70, 95% CI: 1.38–5.25; P=0.003). Conclusion After 9 years, we identified that those with high BODE index, greater CCI, greater frequency of exacerbations in the first 3 years, and BMI ≤21 kg/m2 showed increased risk of death.
18F-PET/CT imaging of metastasis to the thyroid gland: Imaging findings and effect on patient management.

Purpose While metastasis to the thyroid from a primary cancer remote to the thyroid is uncommon, current imaging techniques have improved detection of these intrathyroid metastases. The purpose of this study was to evaluate the 18F-PET/CT appearance of intrathyroid metastases and assess the impact of detection on patient management. Methods The 18F-PET/CT appearance of intrathyroid metastasis, including standardized uptake value (SUV), disease extent, and the effect on patient management following diagnosis were retrospectively reviewed. Inclusion criteria included 18F-PET/CT imaging and diagnosis of the intrathyroid metastasis matching the remote primary tumor. Results Intrathyroid metastasis were detected in 24 patients. The intrathyroid metastases presented on 18F-PET/CT as focal nodular uptake (n = 21), multiple nodular uptake (n = 2), or diffuse uptake/infiltration of the thyroid gland (n = 1). The SUV ranged between 3.9 and 42 (median 12.5 ± 7.5); in 2 patients, the FDG-avidity was minimal. On 18F-PET/CT, distant metastases were present outside the neck (n = 18), or limited to the neck (n = 6). In 2 of these 6 patients, the thyroid was the only site of metastatic disease. Due to the metastatic disease, the therapy was changed in 23 of 24 patients; 1 patient was lost to follow-up. Conclusion In any patient with a previous or current history of an extrathyroid malignancy, an 18FDG-avid thyroid mass or diffuse infiltration of the thyroid on 18F-PET/CT should be considered a potential intrathyoid metastasis until proven otherwise. Knowledge of an intrathyroid metastasis may impact patient management, especially if the thyroid or neck are the only sites of metastatic disease.
PENGARUH KOMPENSASI, MOTIVASI DAN DISIPLIN KERJA TERHADAP KINERJA KARYAWAN UNIVERSITAS MURIA KUDUS

This study aims to examine the influence of Compensation, Work Motivation and Discipline to Performance Employee in Muria Kudus University.The research was conducted by using survey methods to Employees Administrative in Muria Kudus University and analyzed by using regression analysis. The samples in this study were taken 45 people with a view to facilitate researchers in conducting research. While sampling technique used in this study using purposive sampling technique in which the sample collection elements are included in the sample was done on purpose, provided that the sample is representative or representative of the population. The results showed that the variable compensation, motivation and discipline work simultaneously positive and significant influence on employee performance. This is evidenced by the value (Fhitung = 23.705)> (F table = 2.84) and the value of [pvalue (Sig.) = 0.000)] <0.05. based this conclusion it is suggested that leaders can manage the three variables toward the repair or improvement of employee performance.
Review of the Amphibian Immune Response to Chytridiomycosis, and Future Directions

The fungal skin disease, chytridiomycosis (caused by Batrachochytrium dendrobatidis and B. salamandrivorans), has caused amphibian declines and extinctions globally since its emergence. Characterizing the host immune response to chytridiomycosis has been a focus of study with the aim of disease mitigation. However, many aspects of the innate and adaptive arms of this response are still poorly understood, likely due to the wide range of species' responses to infection. In this paper we provide an overview of expected immunological responses (with inference based on amphibian and mammalian immunology), together with a synthesis of current knowledge about these responses for the amphibian-chytridiomycosis system. We structure our review around four key immune stages: (1) the naïve immunocompetent state, (2) immune defenses that are always present (constitutive defenses), (3) mechanisms for recognition of a pathogen threat and innate immune defenses, and (4) adaptive immune responses. We also evaluate the current hot topics of immunosuppression and immunopathology in chytridiomycosis, and discuss their respective roles in pathogenesis. Our synthesis reveals that susceptibility to chytridiomycosis is likely to be multifactorial. Susceptible amphibians appear to have ineffective constitutive and innate defenses, and a late-stage response characterized by immunopathology and Bd-induced suppression of lymphocyte responses. Overall, we identify substantial gaps in current knowledge, particularly concerning the entire innate immune response (mechanisms of initial pathogen detection and possible immunoevasion by Bd, degree of activation and efficacy of the innate immune response, the unexpected absence of innate leukocyte infiltration, and the cause and role of late-stage immunopathology in pathogenesis). There are also gaps concerning most of the adaptive immune system (the relative importance of B and T cell responses for pathogen clearance, the capacity and extent of immunological memory, and specific mechanisms of pathogen-induced immunosuppression). Improving our capacity for amphibian immunological research will require selection of an appropriate Bd-susceptible model species, the development of taxon-specific affinity reagents and cell lines for functional assays, and the application of a suite of conventional and emerging immunological methods. Despite current knowledge gaps, immunological research remains a promising avenue for amphibian conservation management.
Chapitre 11. Fond pédogéochimique et cartographie des pollutions des sols à Lubumbashi

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Fond pédogéochimique et cartographie des pollutions des sols à Lubumbashi Mylor Shutcha, Robert-Prince Mukobo, Donato Kaya Muyumba, Michel Mpundu, Michel-Pierre Faucon, Tolérant Lubalega, Ludovic Andres, Annabelle John, Nathan Vandenheede, Olivier Pourret, et al.
Reformulated mineral trioxide aggregate components and the assessments for use as future dental regenerative cements

Mineral trioxide aggregate, which comprises three major inorganic components, namely, tricalcium silicate (C3S), dicalcium silicate (C2S), and tricalcium aluminate (C3A), is promising regenerative cement for dentistry. While mineral trioxide aggregate has been successfully applied in retrograde filling, the exact role of each component in the mineral trioxide aggregate system is largely unexplored. In this study, we individually synthesized the three components, namely, C3S, C2A, and C3A, and then mixed them to achieve various compositions (a total of 14 compositions including those similar to mineral trioxide aggregate). All powders were fabricated to obtain high purity. The setting reaction of all cement compositions was within 40 min, which is shorter than for commercial mineral trioxide aggregate (~150 min). Over time, the pH of the composed cements initially showed an abrupt increase and then plateaued (pH 10–12), which is a typical behavior of mineral trioxide aggregate. The compression and tensile strength of the composed cements increased (2–4 times the initial values) with time for up to 21 days in an aqueous medium, the degree to which largely depended on the composition. The cell viability test with rat mesenchymal stem cells revealed no toxicity for any composition except C3A, which contained aluminum. To confirm the in vivo biological response, cement was retro-filled into an extracted rat tooth and the complex was re-implanted. Four weeks post-operation, histological assessments revealed that C3A caused significant tissue toxicity, while good tissue compatibility was observed with the other compositions. Taken together, these results reveal that of the three major constituents of mineral trioxide aggregate, C3A generated significant toxicity in vitro and in vivo, although it accelerated setting time. This study highlights the need for careful consideration with regard to the composition of mineral trioxide aggregate, and if possible (when other properties are satisfactory), the C3A component should be avoided, which can be achieved by the mixture of individual components.