Miracle-dz/UniFAR-FTUs huggingface dataset:
Nocturnal Cloud Systems and the Diurnal Variation of Clouds and Rainfall in Southwestern Amazonia

Abstract This paper examines the origins of a secondary nocturnal maximum in cloudiness and precipitation in southwestern Amazonia, a diurnal feature observed previously by many investigators. Analysis is based on satellite, radar, sounding, and profiler observations of precipitating systems and cloudiness from the Tropical Rainfall Measuring Mission Large-Scale Biosphere–Atmosphere (TRMM-LBA) and the coincident Wet-Season Atmospheric Mesoscale Campaign (WETAMC) field programs during the early 1999 wet season. The general finding is that following the collapse of the nearly ubiquitous and locally generated afternoon (“noon balloon”) convection, organized deep convection contributes to a postmidnight maximum in raining area and high cloudiness, and to a lesser extent rainfall. Nocturnal convective systems have the effect of weakening and delaying the onset of the following afternoon's convection. Many of these nocturnal convective events are traced to large- scale squall lines, which propagate westward tho.
Seismoelectric wave propagation modeling for typical laboratory configurations: A numerical validation

The seismoelectric effect can be of importance for hydrocarbon exploration as it is complementary to conventional seismics. Besides enabling seismic resolution and electromagnetic sensitivity at the same time, the seismoelectric method can also provide us with additional, high-value information like porosity and permeability. However, very little is still understood of this complex physical phenomenon. Therefore, it is crucial to be able to perform numerical modeling experiments to carefully investigate the effect and the parameters that play a role. Over the last couple of years, several seismoelectric laboratory experiments have been carried out in an attempt to validate the underlying theory of the phenomenon and to better understand this complex physical phenomenon. We have recently extended our analytically based, numerical seismoelectric modeling code ’ESSEMOD’ to be able to model seismoelectric wave propagation in arbitrarily layered Earth geometries with fluid / porous medium / (fluid) interfaces. In this way, we are capable of effectively simulating full seismoelectric wave propagation, i. e. all existing seismoelectric and electroseismic source-receiver combinations, in typical laboratory configurations. We present the underlying theory that is required for the extension towards arbitrary fluid / porous medium / (fluid) geometries and an effective way to incorporate this in a general seismoelectric layered Earth modeling code. We then validate the underlying global reflection scheme by comparing it with an independently developed layered Earth modeling code for purely electromagnetic fields. The results show a perfect match in both amplitude and phase, indicating that ESSEMOD is correctly modeling the electromagnetic parts of the seismo-electric wave propagation in horizontally layered media with fluid / porous medium / fluid transitions. We finalize with a seismoelectric reciprocal modeling experiment, proving that also the full seismoelectric wave propagation through fluid / porous medium transitions is modeled consistently.
A comparative analysis of the performance of conventional and Islamic unit trust companies in Malaysia

Purpose - The purpose of this paper is to investigate the efficiency of selected conventional and Islamic unit trust companies in Malaysia during the period 2002 to 2005. Design/methodology/approach - The paper adopts Data Envelopment Analysis (DEA) to investigate efficiency, as measured by the Malmquist index, which is decomposed into two components: efficiency change and technical change indexes. Findings - The study indicates that technical efficiency is the main contributor to enhancing the efficiency of the Malaysian unit trust industry. In addition, the larger the size of the unit trust companies, the more inefficient the performance. In comparing the efficiency of unit trust companies, the study finds that some of the Islamic unit trust companies perform better than their conventional counterparts. Research limitations/implications - The study is limited to five Islamic unit trust companies. Thus, the findings of this study are indicative, but inconclusive for the unit trust industry as a whole. Practical implications - The results have two important implications for both conventional and Islamic unit trust companies in Malaysia. First, the deterioration of total factor productivity (TFP) in the unit trust industry in Malaysia is due to the deficiency of innovation in technical components. Second, the size of the unit trust companies has an adverse effect on the TFP performance. Originality/value - The contribution of this study is that it analyzes the efficiency of the two types of unit trust industry which are important and relevant for Malaysia. This significance arises from the dual financial system, in which the Islamic unit trust companies operate in parallel with their conventional counterparts. The comparison sheds some light on the performance of the Islamic unit trust companies, whose operations are based on profit-sharing, in contrast to the conventional unit trust companies.
Negative Association of Proton Pump Inhibitors With Subsequent Development of Breast Cancer: A Nationwide Population‐Based Study

Although current evidence suggests potential antitumor activity of proton pump inhibitors (PPIs), there is no population‐based evidence of an association between PPI use and subsequent breast cancer risks. We used an observational case‐control study to examine the association between prior PPI use and breast cancer occurrence. Additional analysis examined dose‐response and age‐stratified associations of PPIs with breast cancer. This study used data from the Taiwan National Health Insurance Research Dataset. A total of 64,234 women diagnosed with breast cancer between 2004 and in 2013 were selected as cases. Controls were 64,234 women without cancer who were selected by matching them with cases on the basis of sociodemographic characteristics and widely prevalent comorbidities. Each study subject's claims data were tracked back for 5 years to determine precancer prescriptions of PPIs. Logistic regression modeling was used for the analysis. A total of 11,871 (9.24%) women had used PPIs within the prior 5 years, 8.06% and 10.42% among cases and controls, respectively. Breast cancer patients were 25% less likely to have had prior PPI exposure after adjustment for comorbidities that predispose to PPI exposure (95%CI 0.72‐0.78) in the risk of breast cancer occurrence. A dose‐response effect was also detected, with the highest effect, 35% lower PPI odds (95%CI 0.61‐0.70) among patients in the highest exposure category. Our findings may suggest that women at a higher‐than‐average risk of breast cancer may benefit from PPI prescriptions if they have medical conditions that could benefit from PPIs.
Long-term social mobility in Sweden: A three-generation approach

Most research on social and economic mobility assumes a two-generation approach, studying the correlations between the socioeconomic status of, for example, fathers and sons. Much less attention has been given to transmissions of status beyond two generations, and whether social mobility between two generations is maintained also in the third. This issue is of considerable relevance both for our understanding of societal openness and the stability of class structures. In this paper we look at social mobility across three generations in Sweden in the period 1815-1990. Using longitudinal micro-level data from the Scanian Economic-Demographic Database, we identify three-generation genealogies (grandfather, father, son) for which we have full information on social class in prime working ages. We use the EGP occupational class scheme, finding that the major part of the grandfather’s influence on the grandson is cancelled out when the impact from father to son is taken into account. Despite this, we find strong indications of status persistence among individuals whose grandfathers were in the highest social class, exercising a significant and positive influence on the grandson’s probability to end up in the same class. The results also support a regression towards the mean, where upward (downward) intergenerational mobility experienced by the previous generation was strongly associated with downward (upward) mobility in the next.
The accuracy of static computer‐aided implant surgery: A systematic review and meta‐analysis

OBJECTIVES To assess the literature on the accuracy of static computer-assisted implant surgery in implant dentistry. MATERIALS AND METHODS Electronic and manual literature searches were conducted to collect information about the accuracy of static computer-assisted implant systems. Meta-regression analysis was performed to summarise the accuracy studies. RESULTS From a total of 372 articles. 20 studies, one randomised controlled trial (RCT), eight uncontrolled retrospective studies and 11 uncontrolled prospective studies were selected for inclusion for qualitative synthesis. A total of 2,238 implants in 471 patients that had been placed using static guides were available for review. The meta-analysis of the accuracy (20 clinical) revealed a total mean error of 1.2 mm (1.04 mm to 1.44 mm) at the entry point, 1.4 mm (1.28 mm to 1.58 mm) at the apical point and deviation of 3.5°(3.0° to 3.96°). There was a significant difference in accuracy in favour of partial edentulous comparing to full edentulous cases. CONCLUSION Different levels of quantity and quality of evidence were available for static computer-aided implant surgery (s-CAIS). Based on the present systematic review and its limitations, it can be concluded that the accuracy of static computer-aided implant surgery is within the clinically acceptable range in the majority of clinical situations. However, a safety marge of at least 2 mm should be respected. A lack of homogeneity was found in techniques adopted between the different authors and the general study designs.
Microservices migration patterns

Microservices architectures are becoming the defacto standard for building continuously deployed systems. At the same time, there is a substantial growth in the demand for migrating on‐premise legacy applications to the cloud. In this context, organizations tend to migrate their traditional architectures into cloud‐native architectures using microservices. This article reports a set of migration and rearchitecting design patterns that we have empirically identified and collected from industrial‐scale software migration projects. These migration patterns can help information technology organizations plan their migration projects toward microservices more efficiently and effectively. In addition, the proposed patterns facilitate the definition of migration plans by pattern composition. Qualitative empirical research is used to evaluate the validity of the proposed patterns. Our findings suggest that the proposed patterns are evident in other architectural refactoring and migration projects and strong candidates for effective patterns in system migrations.
Anatomical and morphological study of the kidneys of the breeding emu(Dromaius novaehollandiae)

Katarzyna MICHAŁEK*, Danuta SZCZERBIŃSKA, Marta GRABOWSKA, Danuta MAJEWSKA, Maria LASZCZYŃSKA Department of Physiology, Cytobiology, and Proteomics, Faculty of Biotechnology and Animal Husbandry, West Pomeranian University of Technology in Szczecin, Szczecin, Poland Department of Poultry and Ornamental Bird Breeding, West Pomeranian University of Technology in Szczecin, Szczecin, Poland Department of Histology and Developmental Biology, Pomeranian Medical University, Szczecin, Poland
Effect of stocking density and sex on growth performance, meat quality, and intestinal barrier function in broiler chickens

ABSTRACT The objective of the current experiment was to investigate the effect of stocking density and sex on growth performance, meat quality, and intestinal barrier function in broiler chickens. The experiment was conducted in a completely randomized design with a 2 × 4 factorial arrangement consisting of sex and four different stocking densities in battery cages. A total of 540 1‐d‐old Ross 308 broiler chickens were allotted to one of eight treatments with five replicates. Within each sex, birds were raised at four different stocking densities of 15.2, 20.2, 25.3, or 30.4 birds/m2 from 1 to 28 d of age. Different stocking densities were achieved by raising a different number of birds per battery cage with identical floor size (0.76 m × 0.78 m). At the end of the experiment, two birds per replicate were euthanized by CO2 asphyxiation to collect tissue samples for further analyses. Results indicated that no interactions between sex and stocking density were observed for all measurements except for serum lipopolysaccharide (LPS) concentrations. Increasing stocking density decreased (linear, P < 0.01) body weight gain and feed intake, but had no negative effects on meat quality. Trans‐epithelial electrical resistance values, a measure of intestinal permeability, were decreased (linear, P < 0.01) with increasing stocking density, regardless of sex. Accordingly, serum LPS concentrations were increased (linear, P < 0.01) with increasing stocking density. However, increasing stocking density increased serum LPS concentrations in male broiler chickens, but had no effects on female broiler chickens, showing an interaction (P < 0.01). The expression of zonula occludens‐1 (ZO‐1) and junctional adhesion molecule B (JAM‐2) was decreased (linear, P < 0.05) with increasing stocking density. In conclusion, increasing stocking density decreases broiler performance regardless of sex and this negative effect is likely associated with decreased intestinal barrier function.
Altering Physical Activity Influences Insulin Responses to Glucose Ingestion in Healthy Adults

Abstract This study determined if varying physical activity (PA) the day prior to an oral glucose tolerance test (OGTT) differentially influenced postprandial glucose and insulin kinetics. Fifteen healthy, young adults participated in three OGTT trials the morning after performing 50% (LOW), 100% (HABITUAL), or 150% (HIGH) of their habitual PA (determined by 7-day pedometry). Trials were randomized and separated by at least 1-wk. For each OGTT trial, blood glucose and insulin were measured after an overnight fast and at 30-min intervals for 2 h following ingestion of the glucose beverage. Between-trial differences were analyzed using a general linear model with repeated measures. Subjects successfully achieved the desired percentage of habitual steps prior to each trial: LOW: 51±5%, HABITUAL: 99±6%, and HIGH: 149±9%. Fasting blood glucose and glucose total area under the curve (AUC) did not differ between trials. Serum insulin AUC was lower (p<0.05) following the HIGH (34,158±8,786 pmol·min·L−1) compared to the LOW (40,738±9,276 pmol·min·L−1) trial. No differences were observed when the LOW and HIGH trials were compared to HABITUAL. These data suggest that varying the PA level (from 50 to 150% of habitual PA) the day prior to an OGTT influences the insulin (but not blood glucose) response to an OGTT.
Ubiquitin specific protease-13 independently regulates parkin ubiquitination and alpha-synuclein clearance in alpha-synucleinopathies

Ubiquitin specific proteases (USPs) are de-ubiquitinases (DUBs) that control protein ubiquitination cycle. The role of DUBs is poorly understood in neurodegenerative diseases. We found that USP13 is overexpressed in post-mortem Parkinson's disease (PD) brains. We investigated whether changes in USP13 levels can affect two molecules, parkin and alpha-synuclein, that are implicated in PD pathogenesis. Parkin is an E3 ubiquitin ligase that is regulated by ubiquitination and targets certain proteins for degradation, and alpha-synuclein may be ubiquitinated and recycled in the normal brain. We found that USP13 independently regulates parkin and alpha-synuclein ubiquitination in models of alpha-synucleinopathies. USP13 shRNA knockdown increases alpha-synuclein ubiquitination and clearance, in a parkin-independent manner. Furthermore, USP13 overexpression counteracts the effects of a tyrosine kinase inhibitor, Nilotinib, while USP13 knockdown facilitates Nilotinib effects on alpha-synculein clearance, suggesting that alpha-synuclein ubiquitnation is important for its clearance. These studies provide novel evidence of USP13 effects on parkin and alpha-synuclein metabolism and suggest that USP13 is a potential therapeutic target in the alpha-synucleinopathies.
MiRNA-335-5p negatively regulates granulosa cell proliferation via SGK3 in PCOS

Polycystic ovary syndrome (PCOS) is a major cause of infertility in women of reproductive age. However, its exact etiology remains unknown. In this study, we sequenced miRNAs in human follicular fluid and identified 16 downregulated and 3 upregulated miRNAs in PCOS group compared with non-PCOS group. Among the differential expressed miRNAs, miR-335-5p was verified lower abundance in PCOS than non-PCOS group using quantitative real-time PCR. Besides, miR-335-5p negatively correlated with antral follicle count, anti-Müllerian hormone and total testosterone. Bioinformatics analysis identified serum/glucocorticoid-regulated kinase family member 3 (SGK3) as a potential target gene of miR-335-5p. SGK3 is involved in protein kinase B-mammalian target of rapamycin kinase (AKT-mTOR) signaling pathway and cell proliferation. Western blotting and cell counting kit-8 assays demonstrated that miR-335-5p mimic reduced, while miR-335-5p inhibitor increased, SGK3 abundance, AKT-mTOR pathway and cell proliferation in human granulosa-like tumor KGN cells. Dual-luciferase reporter assays showed that miR-335-5p binds to the 3′ untranslated region of SGK3 mRNA. Furthermore, miR-335-5p was decreased and SGK3 was elevated in human granulosa cells obtained from PCOS patients as compared with non-PCOS controls. These findings suggested that miR-335-5p is involved in granulosa cells proliferation by reducing SGK3 expression, which might provide a molecular target to improve dysfunctional granulosa cells in patients with PCOS.
Predicting distribution patterns and recent northward range shift of an invasive aquatic plant: Elodea canadensis in Europe

Climate data and distribution data for the Canadian waterweed Elodea canadensis Michx. from North America, whole Europe and Finland were used to investigate the ability of bioclimatic envelope models to predict the distribution range and recent northward range shift of the species in Europe. Four diff erent main types of models were developed using the North American data, including either three ‘baseline’ climate variables (growing degrees days, temperature of the coldest month, water balance) or an extended set of seven climate variables, both averaged either over a 30 year time slice or a longer 90 year time slice. Ten diff erent random selections of pseudo-absences were generated from the North American data, on the basis of which ten separate generalized additive models (GAMs) were developed for each main model type. All the 40 developed GAMs were applied fi rst to North America and then transferred to whole Europe and Finland. All the models showed a statistically highly signifi cant accuracy in the three study areas. Although the diff erences among the four main model types were only minor, the two extended model types showed on average statistically better performance than the two baseline models based on Bayesian information criterion (BIC) values, the amount of deviance explained by the models, resubstitution validation and four-fold cross-validation in North America. Th ey also provided slightly more accurate predictions of climatically suitable area for Elodea canadensis in Finland both in 1961–1984 and 1985–2006. However, the projections from the individual extended models were more variable than projections from the baseline models. Th us model predictions based on a variety of predictor variables but only one selection of pseudo
Depressive symptoms and mental health-related quality of life in adolescence and young adulthood after early parental death

Aims: Little is known about long-term mental health in young adults who participate in ongoing grief counseling programs after early parental death in childhood, adolescence or young adulthood. The purpose of this study was to examine mental health in young adults according to early parental death and participation in grief counseling. Methods: In a cross-sectional, questionnaire-based study, we included three samples of young adults age 18–41 years. One sample who had lost a parent between age 0 and 30 years and who had participated in grief counseling identified through four Danish grief-counseling organizations, and two registry-based samples of young adults included parentally bereaved and non-bereaved young adults. Multivariate-adjusted regression analyses were performed to characterize risk of depressive symptoms and mental health-related quality of life (HQoL) according to early parental death and participation in grief counseling. Results: A total of 2467 (45%) young adults participated. Bereaved young adults reported significantly more depressive symptoms (p<0.0001) and lower mental HQoL (p<0.0001) than non-bereaved young adults and than general population levels for both depressive symptoms (p<0.0001) and HQoL (p<0.0001). Bereaved young adults who had participated in grief counseling reported significantly more depressive symptoms (p<0.0001) and lower mental HQoL (p<0.0001) than bereaved persons who did not participate in grief counseling. Conclusions: Bereaved young adults report more mental health problems than non-bereaved young adults, and also after participation in grief counseling the death of a parent may be accompanied by subsequent mental health problems.
Accuracy of linear measurements on CBCT images related to presurgical implant treatment planning: A systematic review

OBJECTIVE The aim of this systematic review was to identify, review, analyze, and summarize available evidence on the accuracy of linear measurements when using maxillofacial cone beam computed tomography (CBCT) specifically in the field of implant dentistry. MATERIAL AND METHODS The search was undertaken in April 2017 in the National Library of Medicine database (Medline) through its online site (PubMed), followed by searches in the Cochrane, EMBASE, ScienceDirect, and ProQuest Dissertation and Thesis databases. The main inclusion criterion for studies was that linear CBCT measurements were performed for quantitative assessment (e.g., height, width) of the alveolar bone at edentulous sites or measuring distances from anatomical structures related to implant dentistry. The studies should compare these values to clinical data (humans) or ex vivo and/or experimental (animal) findings from a "gold standard. " RESULTS The initial search yielded 2,516 titles. In total, 22 studies were included in the final analysis. Of those, two were clinical and 20 ex vivo investigations. The major findings of the review indicate that CBCT provides cross-sectional images that demonstrate high accuracy and reliability for bony linear measurements on cross-sectional images related to implant treatment. A wide range of error has been reported when performing linear measurements on CBCT images, with both over- and underestimation of dimensions in comparison with a gold standard. A voxel size of 0.3 to 0.4 mm is adequate to provide CBCT images of acceptable diagnostic quality for implant treatment planning. CONCLUSIONS CBCT can be considered as an appropriate diagnostic tool for 3D preoperative planning. Nevertheless, a 2 mm safety margin to adjacent anatomic structures should be considered when using CBCT. In clinical practice, the measurement accuracy and reliability of linear measurements on CBCT images are most likely reduced through factors such as patient motion, metallic artefacts, device-specific exposure parameters, the software used, and manual vs. automated procedures.