Miracle-dz/UniFAR-FTUs huggingface dataset:
Interpretation of Galileo's Io plasma and field observations: I0, I24, and I27 flybys and close polar passes

[1] We interpret plasma and magnetic field observations taken during the Galileo spacecraft Io flybys I0 in December 1995, I24 in October 1999, and I27 in February 2000, and we give predictions for a generic pass over Io's northern pole with a three-dimensional, two-fluid plasma model. We show that all previous field and plasma observations by the Galileo spacecraft can be explained without the assumption of an internal magnetic field of Io in contrast to claims by Kivelson et al. [1996a, 1996b] and Khurana et al. [1997]. We are also able to reproduce both the magnitude and the structure of the double-peak magnetic field signature of the I0 flyby. The origin of this structure can be attributed to diamagnetic and inertia currents. Observations by a polar flyby should answer Io's internal magnetic field question decisively. We also study the effect of different neutral atmosphere models on Io's electrodynamic interaction. Our analysis suggests that Io's atmosphere is longitudinally asymmetric with the scale height on the upstream side smaller than on the downstream side due to the drag force of the flowing plasma on Io's atmosphere. We also show how the Hall effect in Io's ionosphere generates rotated Alfven wings. In addition, the high-energy electrons observed by Williams et al. [1996, 1999] and Frank and Paterson [1999] might play an important role for the formation of Io's downstream wake.
Levels of processing: Past, present... and future?

In this article I first briefly survey some enduring legacies of the Craik and Lockhart (1972) article on levels of processing (LOP) and address some common criticisms. In the next section I discuss whether memory can be regarded as “pure processing”, the role of short-term memory in an LOP framework, measurement of “depth” in LOP, encoding-retrieval interactions, the concept of consolidation, and the reality of “levels” of processing. In the final section I offer some speculations on future directions, discussing the notion of levels of representation and a possible continuing role for LOP in memory research.
Accelerated hyperfractionated total-lymphoid irradiation, high-dose chemotherapy, and autologous bone marrow transplantation for refractory and relapsing patients with Hodgkin's disease.

PURPOSE To evaluate the feasibility and therapeutic effect of accelerated hyperfractionated total-lymphoid irradiation (TLI), high-dose chemotherapy, and autologous bone marrow transplantation (AuBMT) in patients with relapsing or chemotherapy-resistant Hodgkin's disease (HD). PATIENTS AND METHODS Forty-seven patients with HD who either relapsed after chemotherapy (n = 19), or failed to respond (n = 28) to at least two regimens of combination chemotherapy were studied. No patient received prior radiation therapy (RT). Treatment started with reinduction with standard-dose chemotherapy, followed by involved-field irradiation (15 Gy) to areas of relapsed or persistent disease and TLI (20.04 Gy given in 1.67 Gy fractions three times per day for 4 days). Subsequently, patients received etoposide and high-dose cyclophosphamide, followed by infusion of unpurged autologous bone marrow. All surviving patients had a minimum follow-up duration of 1 year. The median follow-up duration for survivors was 40+ months, and the maximum follow-up duration was 80+ months. RESULTS Of the 47 patients treated, eight (17%) died of toxicity during the peritransplant period. Twenty-nine of the remaining 39 assessable patients (74%) attained a complete response (CR), while 10 remained with residual disease and progressed early after AuBMT. Four of the CR patients (14%) relapsed and 25 patients remained alive and free of disease. The actuarial disease-free survival (DFS) rate for the entire group at 6.5 years was 50%. Patients who received the protocol for relapsing HD had a significantly better DFS rate (79%) compared with patients treated for continuous refractory disease (DFS, 33%; P < .03). CONCLUSION Previously unirradiated patients with relapsing or chemotherapy-resistant HD who have exhausted conventional chemotherapy may still respond to an aggressive therapeutic approach consisting of accelerated hyperfractionated TLI, high-dose chemotherapy, and AuBMT rescue. This program offers a potential for long-term DFS to approximately one half of patients who would otherwise have a dismal prognosis with standard-dose salvage therapy.
Activation and clustering of a Plasmodium falciparum var gene are affected by subtelomeric sequences

The Plasmodium falciparum var multigene family encodes the cytoadhesive, variant antigen PfEMP1. P. falciparum antigenic variation and cytoadhesion specificity are controlled by epigenetic switching between the single, or few, simultaneously expressed var genes. Most var genes are maintained in perinuclear clusters of heterochromatic telomeres. The active var gene(s) occupy a single, perinuclear var expression site. It is unresolved whether the var expression site forms in situ at a telomeric cluster or whether it is an extant compartment to which single chromosomes travel, thus controlling var switching. Here we show that transcription of a var gene did not require decreased colocalisation with clusters of telomeres, supporting var expression site formation in situ. However following recombination within adjacent subtelomeric sequences, the same var gene was persistently activated and did colocalise less with telomeric clusters. Thus, participation in stable, heterochromatic, telomere clusters and var switching are independent but are both affected by subtelomeric sequences. The var expression site colocalised with the euchromatic mark H3K27ac to a greater extent than it did with heterochromatic H3K9me3. H3K27ac was enriched within the active var gene promoter even when the var gene was transiently repressed in mature parasites and thus H3K27ac may contribute to var gene epigenetic memory.
Quality assured efficient engineering of feedforward neural networks with supervised learning (QUEEN) evaluated with the"pima indians diabetes database"

The QUEEN method is based on four main concepts: 1 The QUEEN phase model is derived from the spiral model for the evaluation of the constructed neural network; 2. An overall strategy for the development process enables a continuous supervision, assessment and quality assurance of each step, from the collection of the examples to the evaluation of the constructed neural network. For the assessment of the quality achieved in the development process, a novel quality indicator is introduced. This indicator gives a measure of the complexity of a task in a given representation. This strategy of QUEEN involves the stepwise simplification of the task; 3. The development of the neural networks is structured by the definition of an order over neural networks. The order takes into account the complexity of the interpretation of the neural network by an expert of the application domain. To yield easily interpretable neural networks, and also to get simple models that enable the detection of data artefacts, the development is started with the simplest adequate neural network; 4. The developer is provided with a set of diagnostic methods and tools that will identify and eliminate reasons for difficulties. The novel quality indicator for example, provides the developer with a diagnostic tool that will identify situations where a representation or a network is unnecessarily complex. QUEEN was developed and successfully evaluated in more than 20 projects mostly in the medical application domain. The paper presents the concepts of QUEEN and describes how QUEEN was applied to set-up a feedforward neural network on the pima indians diabetes database, a database that has been used as a benchmark in several studies, QUEEN highlighted several severe data artefacts in this database.
Stimulating citizenship or expanding entertainment? The effect of Facebook on adolescent participation

Over the past decade, Internet and politics scholarship has been concerned with the effects of the Internet on forms of civic and political participation. Recent research has moved on to examine the effects of social networking sites like Facebook. Although past studies have generally found positive – albeit weak or moderate – relationships between social networking sites use and civic and political participation, reliance on cross-sectional surveys has not produced conclusive evidence of the direction of causality. We use a two-wave panel survey of 15- and 16-year-olds to examine how Facebook use affects various forms of political and non-political entertainment-oriented participation (both online and offline). We find that Facebook use is positively related to civic and entertainment-oriented, but not to online or offline political, participation. Further analysis using structural equation modelling shows that prior levels of civic participation have a stronger effect on Facebook use than Facebook use has on civic participation. Facebook use only leads clearly to entertainment-oriented participation. The implications of these findings are discussed.
Understanding vaccination rates and attitudes among patients with rheumatoid arthritis.

OBJECTIVES Appropriate vaccinations are important for patients with rheumatoid arthritis (RA), who are often treated with highly immunosuppressive therapies that increase their risk of infection. However, rates of vaccination among patients with RA are below optimal levels. STUDY DESIGN We conducted a patient survey to assess self-reported vaccination status and to compare that status with electronic health record (EHR) data. METHODS We recruited randomly selected patients with RA in an academic practice in 2013. Eligible participants had a diagnosis of RA, at least 1 visit to a rheumatology clinic in each of the previous 2 years, were 18 years or older, and had English listed as their preferred language. The survey included the following domains: a) patient self-reported receipt of influenza, pneumococcal (PNVX), and herpes zoster (HZVX) vaccinations; b) attitudes about these vaccines, including reasons for unvaccinated status, if applicable; and c) provider recommendations about these vaccines. RESULTS Based on participants' self-report, we found a high vaccination rate for influenza during the previous season (79.4%), a moderate rate of any previous vaccination for pneumococcus (53.9%), and a very low rate of any previous vaccination for herpes zoster (7.8%). If we assume that all self-reports are accurate and we include vaccinations recorded in the EHR that were not reported by patients, the vaccination rates were approximately 8% to 9% higher for PNVX and HZVX. CONCLUSIONS Vaccination rates are low among patients with RA based on self-report data. Further research is needed to investigate system-level barriers to vaccination and the impact of evidence-based, provider-level interventions on vaccination rates.
Unusual, rapidly growing ulcerative genital mass due to herpes simplex virus in a human immunodeficiency virus‐infected woman

SIR, Mycosis fungoides (MF) is characterized by clonal helper ⁄ memory (CD4+ CD45RO+) T-cells in the epidermis, whereas follicular mucinosis or alopecia mucinosis has perifollicular T-cell infiltrates and may clinically resemble alopecia areata. Bexarotene is the first retinoid X receptor (RXR)-selective retinoid shown to be effective for cutaneous T-cell lymphoma. Bexarotene has recently been shown to induce T-cell apoptosis in vitro. Although bexarotene oral and topical gel are effective for MF, this is the first report, to our knowledge, of reversal of associated alopecia. Five patients with alopecia secondary to MF or follicular mucinosis were observed among a cohort of over 90 patients receiving bexarotene therapy at the M.D. Anderson Cancer Center. Their demographic data, degree of hair loss, skin biopsy results and drug administration are shown in Table 1. The location of the hair loss was confined to the scalp in four patients and to the extremities in a fifth. All of the skin biopsy specimens revealed atypical CD4+ CD8+ perifollicular lymphocytic infiltrates, and two showed mucin deposits consistent with follicular mucinosis. Three patients had scaling with negative fungal cultures. Patients with early stage MF were treated with topical bexarotene therapy and advanced stage patients with oral bexarotene. The MF as well as the alopecia improved in all five patients, irrespective of the route of delivery. Hair regrowth began within 2–9 months and full regrowth was evident by 1Æ5 years. Patient 1. A 77-year-old Native American woman presented with a 3-month history of a single patch of alopecia accompanied by pruritus and mild tenderness, generalized xerosis, fatigue and a 4Æ5-kg unintentional weight loss. Asthma and childhood eczema were noted. There was a 4 · 5 cm alopecia areata-like lesion with scaling on the scalp (Fig. 1a) and macular erythema of less than 1%. An atypical CD4+ CD8– clonal lymphocytic infiltrate and mucin deposits were present in the follicular epithelium. After applying 1% bexarotene gel daily to the leg and scalp lesions, partial hair regrowth was present at 3 months (Fig. 1b), with full regrowth of terminal grey hair covering the former patch of alopecia at 5 months (Fig. 1c). Patient 2. A 64-year-old Hispanic man with dermatitis for 30 years developed generalized exfoliative erythroderma, patchy alopecia, and a skin biopsy consistent with MF. He had increased fatigue, chills, night sweats and intense pruritus. On examination, he had generalized exfoliative erythroderma and lymphadenopathy. On the scalp, multiple round alopecia areata lesions, patches of white hair, and exclamation point hairs were observed (Fig. 2a,b). An atypical CD4+ CD8+ dermal infiltrate with epidermotropism and a clonal T-cell receptor gene rearrangement were observed in
Relationship between mean platelet volume and ischemic stroke in patients with patent foramen ovale.

OBJECTIVE Patent foramen ovale (PFO) is commonly encountered in patients with cryptogenic stroke. Mean platelet volume (MPV), an indicator of platelet reactivity, has been reported in recent trials to be higher in patients with PFO than in normal population. The aim of this study was to investigate whether there is a difference in MPV between patients with PFO and stroke or transient ischemic attack (TIA) and that of patients with asymptomatic PFO. METHODS Patients with PFO who were younger than 55 years of age were enrolled in this retrospective study. Hemogram parameters of patients with ischemic stroke or TIA (symptomatic group) were obtained during hospitalization once they had stable clinical status. RESULTS Total of 108 patients, 51 of whom were symptomatic, were included in the study. MPV was determined to be higher in symptomatic group compared with asymptomatic group (median 10.0 fl [25th-75th percentile: 9.0-11.0] vs median 8.56 fl [25th-75th percentile: 8.0-9.0], respectively; p<0.001,. Cut-off point of 9.0 fl for MPV had 70% sensitivity and 86% specificity in predicting symptomatic PFO patients. CONCLUSION MPV is higher in symptomatic than in asymptomatic PFO patients. This finding may be a subsidiary risk factor to identify patients with PFO and high risk of cardioembolic stroke.
Isolation of pheromone precursor genes of Magnaporthe grisea.

In heterothallic ascomycetes one mating partner serves as the source of female tissue and is fertilized with spermatia from a partner of the opposite mating type. The role of pheromone signaling in mating is thought to involve recognition of cells of the opposite mating type. We have isolated two putative pheromone precursor genes of Magnaporthe grisea. The genes are present in both mating types of the fungus but they are expressed in a mating type-specific manner. The MF1-1 gene, expressed in Mat1-1 strains, is predicted to encode a 26-amino-acid polypeptide that is processed to produce a lipopeptide pheromone. The MF2-1 gene, expressed in Mat1-2 strains, is predicted to encode a precursor polypeptide that is processed by a Kex2-like protease to yield a pheromone with striking similarity to the predicted pheromone sequence of a close relative, Cryphonectria parasitica. Expression of the M. grisea putative pheromone precursor genes was observed under defined nutritional conditions and in field isolates. This suggests that the requirement for complex media for mating and the poor fertility of field isolates may not be due to limitation of pheromone precursor gene expression. Detection of putative pheromone precursor gene mRNA in conidia suggests that pheromones may be important for the fertility of conidia acting as spermatia.
Challenging HIV vulnerability discourse: the case of professional and entrepreneurial women in Dar Es Salaam, Tanzania

Abstract A poverty-HIV narrative has dominated many HIV prevention strategies in Africa despite epidemiological data showing higher prevalence of infection among educated and wealthier women in several African countries. This paper examines the perspectives of professional and entrepreneurial women on HIV risk and vulnerability based on their knowledge and lived experiences, comparing this to the HIV discourse evident in five strategic documents that shape intervention in Tanzania. The purpose is to uncover the confluence and dissonance between the discourses of government and those of professional women themselves. Qualitative research methods included critical discourse analysis of five strategic documents and thematic analysis of 37 in-depth interviews with women. The findings challenge fixed representations of women and notions of vulnerability embedded in the poverty-HIV discourse. Women described using their sexuality and sexual agency as a means to elevate their position in ways that made them vulnerable to sexual harassment and coercion. This is explored through two intersecting themes: non-marital sexual exchanges to gain an education or employment, and marriage. The intersecting social positions and constructions of female sexuality and agency expressed by the women in this study provide insights into other avenues and forms of HIV vulnerability.
Strategies and Challenges for Systematically Mapping Biologically Significant Molecular Pathways Regulating Carcinoma Epithelial-Mesenchymal Transition

Enormous progress has been made towards understanding the role of specific factors in the process of epithelial-mesenchymal transition (EMT); however, the complex underlying pathways and the transient nature of the transition continues to present significant challenges. Targeting tumour cell plasticity underpinning EMT is an attractive strategy to combat metastasis. Global gene expression profiling and high-content analyses are among the strategies employed to identify novel EMT regulators. In this review, we highlight several approaches to systematically interrogate key pathways involved in EMT, with particular emphasis on the features of multiparametric, high-content imaging screening strategies that lend themselves to the systematic discovery of highly significant modulators of tumour cell plasticity.
Multivariable analysis of DNA ploidy, p53, and HER‐2/neu as prognostic factors in endometrial cancer

Background. Several molecular‐genetic alterations in endometrial cancers, including aneuploidy and aberrant expression of p53 and HER‐2/neu, have been associated with poor prognosis. To determine the importance of molecular‐genetic factors relative to more traditional surgical‐pathologic prognostic factors, a multivariable analysis was performed.
Fragile‐to‐Strong Crossover in Supercooled Liquid Ag‐In‐Sb‐Te Studied by Ultrafast Calorimetry

Phase‐change random‐access memory relies on the reversible crystalline‐glassy phase change in chalcogenide thin films. In this application, the speed of crystallization is critical for device performance: there is a need to combine ultrafast crystallization for switching at high temperature with high resistance to crystallization for non‐volatile data retention near to room temperature. In phase‐change media such as nucleation‐dominated Ge2Sb2Te5, these conflicting requirements are met through the highly “fragile” nature of the temperature dependence of the viscosity of the supercooled liquid. The present study explores, using ultrafast‐heating calorimetry, the equivalent temperature dependence for the growth‐dominated medium Ag‐In‐Sb‐Te. The crystallization shows (unexpectedly) Arrhenius temperature dependence over a wide intermediate temperature range. Here it is shown that this is evidence for a fragile‐to‐strong crossover on cooling the liquid. Such a crossover has many consequences for the interpretation and control of phase‐change kinetics in chalcogenide media, helping to understand the distinction between nucleation‐ and growth‐dominated crystallization, and offering a route to designing improved device performance.
Chronic bronchopulmonary disease and gastroesophageal reflux in children

Fifty‐four children who had chronic bronchopulmonary disease (CBPD) were investigated for the incidence of gastroesophageal reflux (GER). An activity score for CBPD and a numerical reflux score using criteria from a pH probe study were established. Results of barium esophagography, endoscopy, and prolonged esophageal pH probe monitoring were abnormal in 67, 78, and 53% of the patients, respectively. A significant relationship was found between the CBPD activity score and the reflux score; this strongly suggests that, in the patients studied, GER was responsible for the bronchopulmonary symptoms. Antireflux therapy resulted in an improvement of the CBPD activity score in all patients who had abnormal reflux scores. The mean CBPD activity score was 4.4 and 1.3 before and after antireflux therapy, respectively (P < 0.01). Most patients who had normal reflux scores did not improve on antireflux therapy.
Human immature dental pulp stem cells’ contribution to developing mouse embryos: production of human/mouse preterm chimaeras

Objectives: In this study, we aimed at determining whether human immature dental pulp stem cells (hIDPSC) would be able to contribute to different cell types in mouse blastocysts without damaging them. Also, we analysed whether these blastocysts would progress further into embryogenesis when implanted to the uterus of foster mice, and develop human/mouse chimaera with retention of hIDPSC derivates and their differentiation.
Multilevel social spaces: The network dynamics of organizational fields

Abstract In this paper, we seek to advance an updated concept of social space that integrates the multilayer and dynamic statistical network methods currently at the disposal of social network researchers. We demonstrate the analytic value of the new concept of social space that we propose with the help of an illustrative analysis of an organizational field involving organizations' external and internal decisions that congeal into a multilevel system of action that shapes the space of possibilities for other participants in the field. Through these internal and external decisions, organizations seek certain positions in their social space while simultaneously modifying that social space over time. We conclude by arguing that network researchers' choices of goodness-of-fit statistics should reflect a consideration about the dimensions of social space of most interest to the nodes involved.