Miracle-dz/UniFAR-FTUs huggingface dataset:
Accumulating Evidence About What Prospective Memory Costs Actually Reveal

Event-based prospective memory (PM) tasks require participants to substitute an atypical PM response for an ongoing task response when presented with PM targets. Responses to ongoing tasks are often slower with the addition of PM demands (“PM costs”). Prominent PM theories attribute costs to capacity-sharing between the ongoing and PM tasks, which reduces the rate of processing of the ongoing task. We modeled PM costs using the Linear Ballistic Accumulator and the Diffusion Decision Model in a lexical-decision task with nonfocal PM targets defined by semantic categories. Previous decision modeling, which attributed costs to changes in caution rather than rate of processing (Heathcote et al., 2015; Horn & Bayen, 2015), could be criticized on the grounds that the PM tasks included did not sufficiently promote capacity-sharing. Our semantic PM task was potentially more dependent on lexical decision resources than previous tasks (Marsh, Hicks, & Cook, 2005), yet costs were again driven by changes in threshold and not by changes in processing speed (drift rate). Costs resulting from a single target focal PM task were also driven by threshold changes. The increased thresholds underlying nonfocal and focal costs were larger for word trials than nonword trials. As PM targets were always words, this suggests that threshold increases are used to extend the time available for retrieval on PM trials. Under nonfocal conditions, but not focal conditions, the nonword threshold also increased. Thus, it seems that only nonfocal instructions cause a global threshold increase because of greater perceived task complexity.
Comparison of central corneal thickness measured with Orbscan and Pentacam.

PURPOSE To compare central corneal thickness measurements obtained with Orbscan II using the acoustic equivalent correction factor (CF) and Pentacam in eyes screened for refractive surgery. METHODS Central corneal thickness in 91 eyes of 51 volunteers with a spherical equivalent refraction ranging from -17.00 to +5.50 diopters (D) (mean: -3.75+/-4.19 D) was measured with both Orbscan II (CF) and Pentacam prior to refractive surgery. RESULTS Central comeal thickness measurements ranged from 438 to 610 microm with Orbscan II (CF) and from 472 to 634 microm with Pentacam. The differences between Pentacam and Orbscan II (CF) measurements ranged from -43 to +52 microm (mean: -13.98+/-14.79 microm); these differences were statistically significant (P<.0001). No correlation was found between the difference in central corneal thickness and refractive error. CONCLUSIONS These results suggest measurements obtained with the Orbscan II (CF) are thinner than those obtained with the Pentacam. Further studies are needed to determine which instrument is more accurate in measuring central corneal thickness.
Calcitonin Administration in a Rabbit Distraction Osteogenesis Model

The effect of salmon calcitonin on the maturation of the regenerate bone was assessed in an experimental model in rabbits. Twenty-six New Zealand White male rabbits, approximately 5 months old and weighing 3 to 3.5 kg, were subjected to a middiaphyseal tibial osteotomy. After 5 days, the right tibia was lengthened gradually at a rate of 0.375 mm every 12 hours, for 10 days. Ten international units of salmon calcitonin were administered daily subcutaneously to the study group (14 animals), whereas the animals of the control group (12 animals) were injected with a placebo, for the duration of the experiment. The bone mineral density of the regenerate bone was assessed on Days 20, 35, 45, and 55 of the experiment, in both groups, using dual energy xray absorptiometry. No statistical significant difference was found in the dual energy xray absorptiometry measurements between the study and control groups regarding the change of the bone mineral density of the new bone relative to a preoperative baseline measurement. Characteristic time-related changes were observed in the bone mineral density of the regenerate bone during its maturation, which proved to be identical in both groups. It seems that the administration of calcitonin does not enhance regenerate bone mineralization rate and tendency during bone lengthening.
Mongols and Mamluks: The Mamluk-Ilkhanid War, 1260–1281

Introduction 1. The historical background 2. The battle of 'Ayn Jalut 3. The formation of anti-Ilkhanid policy 4. The search for a second front 5. Military and diplomatic skirmishing 6. The secret war 7. Baybars' intervention in Seljuq Rum 8. Baybars' posthumous victory: the second battle of Homs 9. The Mamluk-Ilkhanid frontier 10. Mamluks versus Mongols: an overview.
Comparative efficacy of adjuvant chemotherapy in patients with Dukes' B versus Dukes' C colon cancer: results from four National Surgical Adjuvant Breast and Bowel Project adjuvant studies (C-01, C-02, C-03, and C-04)

PURPOSE Although the benefit from adjuvant chemotherapy has been clearly established in patients with Dukes' C colon cancer, such benefit has been questioned in patients with Dukes' B disease. To determine whether patients with Dukes' B disease benefit from adjuvant chemotherapy and to evaluate the magnitude of the benefit, compared with that observed in Dukes' C patients, we examined the relative efficacy of adjuvant chemotherapy according to Dukes' stage in four sequential National Surgical Adjuvant Breast and Bowel Project trials (C-01, C-02, C-03, and C-04) that compared different adjuvant chemotherapy regimens with each other or with no adjuvant treatment. PATIENTS AND METHODS The four trials included Dukes' B and C patients and were conducted between 1977 and 1990. The eligibility criteria and follow-up requirements were similar for all four trials. Protocol C-01 compared adjuvant semustine, vincristine, and fluorouracil (5-FU) (MOF regimen) with operation alone. Protocol C-02 compared the perioperative administration of a portal venous infusion of 5-FU with operation alone. Protocol C-03 compared adjuvant 5-FU and leucovorin (LV) with adjuvant MOF. Protocol C-04 compared adjuvant 5-FU and LV with 5-FU and levamisole (LEV) and with the combination of 5-FU, LV, and LEV. RESULTS Forty-one percent of the patients included in these four trials had resected Dukes' B tumors. In all four studies, the overall, disease-free, and recurrence-free survival improvement noted for all patients was evident in both Dukes' B and Dukes' C patients. When the relative efficacy of chemotherapy was examined, there was always an observed reduction in mortality, recurrence, or disease-free survival event, irrespective of Dukes' stage, and in most instances, the reduction was as great or greater for Dukes' B patients as for Dukes' C patients. When data from all four trials were examined in a combined analysis, the mortality reduction was 30% for Dukes' B patients versus 18% for Dukes' C patients. The mortality reduction in Dukes' B patients occurred irrespective of the presence or absence of adverse prognostic factors. CONCLUSION Patients with Dukes' B colon cancer benefit from adjuvant chemotherapy and should be presented with this treatment option. Regardless of the presence or absence of other clinical prognostic factors, Dukes' B patients seem to benefit from chemotherapy administration.
Adjuvant chemotherapy versus chemotherapy plus pelvic irradiation for high-risk cervical cancer patients after radical hysterectomy and pelvic lymphadenectomy (RH-PLND): a randomized phase III trial.

OBJECTIVE To compare the clinical efficacy of adjuvant chemotherapy a lone vs chemotherapy plus whole pelvic radiation therapy (RT) on recurrence rates, patterns of recurrence, and survival of patients post-RH-PLND for cervical cancer at high risk for recurrence. METHODS Prospective multicenter randomized Phase III trial. Patients with Stage IB-IIA cervical cancer undergoing RH-PLND were eligible. Risk factors include deep cervical invasion, tumor > or = 4 cm, parametrial involvement, nonsquamous histology, and/or pelvic lymph node metastasis. Chemotherapy consisted of cisplatin and bleomycin, alone or in combination with whole pelvic RT. Survival was determined by Kaplan-Meier estimate. RESULTS Eighty-nine patients were entered from 1987 to 1994. Seventy-five patients had a Stage IB cancer and 14 patients had Stage IIA. Twenty-five patients had > or = 3 risk factors. Forty-four patients received chemotherapy alone vs 45 patients treated with chemotherapy and RT. Nineteen patients had recurrences and 16 patients have died. Nine of 44 (20%) patients receiving chemo alone recurred compared to 10/45 (22%) patients receiving chemo and RT (P=ns). Patterns of recurrence were statistically similar between the two treatment arms, even among the subgroup of patients with > or = 3 risk factors. Both regimens were well tolerated. CONCLUSION CT + RT did not prove a superior adjuvant therapy for patients at high risk of recurrence after RH-PLND for early cervical cancer in this limited trial. Recurrence rates and patterns of recurrences (local, regional, or distant) were not influenced by the addition of RT.
[Effects of different dosages of cyclosporine A on the semen parameters of renal transplant patients].

OBJECTIVES To evaluate the effects of different dosages of cyclosporine A (CsA) on the main semen parameters and sperm morphology of the patients after renal transplantation. METHODS The semen of 18 patients after renal transplantation treated with different dosages of CsA was analyzed and the semen parameters and sperm morphology were compared with those of 12 normal volunteers. RESULTS There was not significant difference between the main parameters of the patients treated with 1.5-3.0 mg.Kg-1.d-1 of CsA and 3.1-5.5 mg.Kg-1.d-1 of CsA and those of the volunteers (P > 0.05), but the rate of normal sperm morphology was significantly different between the two groups(P < 0.05). CONCLUSIONS Different therapeutic dosages of CsA did not have any effect on most of the semen parameters of the patients after renal transplantation, but did affect the sperm morphology.
Use of flow cytometry (Sysmex® UF-100) to screen for positive urine cultures: in search for the ideal cut-off

Abstract Background: Cultures for urinary tract infections (UTI) constitute a large workload in the clinical microbiology laboratory, although up to 80% are usually negative. Several automated methods are available to screen urines for UTI, one being the flow cytometry-based Sysmex® UF-100. Methods: The performance of the UF-100 was evaluated over a 16-month period using urine culture as the reference method. Results: During this period, a total of 5356 urine samples were studied (469 children; 3229 women and 1658 men), of which 706 were culture positive (593 grew Gram negative bacilli). Receiver operating characteristics (ROC) curve analysis showed an area under the curve (AUC) of 0.83 for leukocytes and 0.85 for bacterial count. Applying cut-off values reported in the literature gave sensitivities ranging from 75% to 90%, resulting in 73–174 false negatives (FN). Using a logical combination (leukocytes ≥15×106/L OR bacteria ≥500×106/L) gave a sensitivity of 98%. However, the specificity dropped to 25%, resulting in 15 FN. Conclusions: Screening urine samples for UTI detects a large number of culture positive samples. However, the rather large number of FN observed precludes the use of the UF-100 as a routine screening method to exclude urine samples from culture. Clin Chem Lab Med 2010;48:289–92.
Increased anxiety-like behavior and ethanol self-administration in dependent rats: reversal via corticotropin-releasing factor-2 receptor activation.

BACKGROUND Corticotropin-releasing factor (CRF) has been hypothesized to be one of the main regulators of the stress response observed during alcohol withdrawal. The CRF receptor subtypes seem to have a differential role in the regulation of stress-related behavior. Given the behavioral characterization of these receptors, the objective of the following experiments was to characterize the role of CRF2 receptors in the interaction between alcohol and stress by examining the effects of CRF2 receptor activation in the behavioral stress response and ethanol self-administration during early ethanol withdrawal in dependent rats. METHODS Male Wistar rats were made dependent on ethanol via chronic exposure to an ethanol containing liquid diet. Behavior in the elevated plus maze and ethanol self-administration were measured at 2 hr after removal of the diet. The role of the CRF2 receptor in the regulation of these behaviors during the early stages of withdrawal was examined via central injection of the highly selective CRF2 receptor agonist urocortin 3. RESULTS Rats showed decreased exploration of the open arms of the elevated plus maze, an indication of a heightened behavioral stress response, after chronic ethanol exposure. This effect was attenuated by central injection of urocortin 3. In addition, urocortin 3 injections reversed the increase in ethanol self-administration observed during early withdrawal in dependent rats. CONCLUSIONS Reversal of the increased stress-related behavior in the elevated plus maze observed after injections of urocortin 3 indicates that the decreased responding for ethanol also seen after urocortin 3 administration is likely due to a diminished anxiety-like state. These data suggest that activation of the CRF2 receptor may provide a novel target in the attenuation of the stress response characteristic of the early stages of ethanol withdrawal.
Extending the Time Limit for Starting the Yuzpe Regimen of Emergency Contraception to 120 Hours

OBJECTIVE Current protocols state that the Yuzpe regimen of emergency contraception can be initiated up to 72 hours after unprotected intercourse. The purpose of this study was to determine whether the window for emergency hormonal contraception can be extended to 120 hours. METHODS In an observational study, we tracked 111 women who requested emergency contraception between 72 and 120 hours after unprotected sex but refused postcoital copper intrauterine devices (IUDs), preferring instead the Yuzpe regimen. We compared failure rates for this group with rates among 675 otherwise similar women who started the same therapy within 72 hours. RESULTS Both perfect use (1.9%) and typical use (3.6%) failure rates were low among women presenting between 72 and 120 hours after unprotected intercourse. These rates did not statistically differ from failure rates for the standard Yuzpe regimen (2.0% during perfect use and 2.5% during typical use). Our small sample size of 111, however, gave us just 25% power to detect a doubling in the failure rates (2% to 4%) and 59% power to detect a tripling in the failure rates (2% to 6%). CONCLUSION The 72-hour cutoff for the Yuzpe regimen of emergency contraception appears needlessly restrictive. Women who request this therapy more than 72 hours after unprotected sex should be allowed to receive it, particularly if they decline postcoital insertion of a copper IUD and would otherwise have no options for reducing pregnancy risk.
Modeling Contrast-Imaging-Assisted Optimal Targeted Drug Delivery: A Touchable Communication Channel Estimation and Waveform Design Perspective

To maximize the effect of treatment and minimize the adverse effect on patients, we propose to optimize nanorobots-assisted targeted drug delivery (TDD) for locoregional treatment of tumor from the perspective of touchable communication channel estimation and waveform design. The drug particles are the information molecules; the loading/injection and unloading of the drug correspond to the transmitting and receiving processes; the concentration-time profile of the drug particles administered corresponds to the signaling pulse. Given this analogy, we first propose to use contrast-enhanced microwave imaging (CMI) as a pretherapeutic evaluation technique to determine the pharmacokinetic model of nanorobots-assisted TDD. The CMI system applies an information-theoretic-criteria-based algorithm to estimate drug accumulation in tumor, which is analogous to the estimation of channel impulse response in the communication context. Subsequently, we present three strategies for optimal targeted therapies from the communication waveform design perspective, which are based on minimization of residual drug molecules at the end of each therapeutic session (i.e., inter-symbol interference), maximization of duration when the drug intensity is above a prespecified threshold during each therapeutic session (i.e., non-fade duration), and minimization of average rate that a therapeutic operation is not received correctly at tumor (i.e., bit error rate). Finally, numerical examples are applied to demonstrate the effectiveness of the proposed analytical framework.
Daytime variability of baroreflex function in patients with obstructive sleep apnoea: implications for hypertension

Obstructive events during sleep in patients with obstructive sleep apnoea (OSA) cause large alterations in blood pressure, and this may lead to changes in baroreflex function with implications for long‐term blood pressure control. This study examined the daytime variations in the responses to carotid baroreceptor stimulation in OSA patients. We determined the cardiac and vascular responses every 3 h between 09.00 and 21.00 h in 20 patients with OSA, using graded suctions and pressures applied to a neck collar. These responses were plotted against estimated carotid sinus pressures and, from these plots, baroreflex sensitivities and operating points were taken as the maximal slopes and the corresponding carotid sinus pressures, respectively. We found that at 09.00 h, sensitivity for the control of vascular resistance was at its lowest (−1.2 ± 0.2% mmHg−1, compared with −1.9 ± 0.3% mmHg−1 at 12.00 h, P < 0.02) and operating point for control of mean arterial pressure was at its highest (101.1 ± 5.8 mmHg, compared with 94.1 ± 5.8 mmHg at 12.00 h, P < 0.05). This is in contrast to previous data from normal subjects, in whom sensitivity was highest and operating point lowest at 09.00 h. We suggest that the higher baroreflex sensitivity and lower operating point seen in the mornings in normal subjects may provide a protective mechanism against hypertension and that this protection is absent in patients with OSA. It is possible that the reduced reflex sensitivity and increased operating point in the mornings may actually promote hypertension.
Endemic pemphigus foliaceus over a century: Part I

Background: Endemic pemphigus foliaceus (EPF) is the only known autoimmune disease presenting in circumscribed geographic areas. Aim: We aim to provide information concerning the natural course of EPF, including systemic compromise in the presteroid era, which has been largely unavailable in the current medical literature. Material & Methods: By a retrospective review of the literature we aim to compile and compare the focus of EPF and the current knowledge about them. The main aim of this review is to summarize our current knowledge of EPF, including data described almost one century ago; and, to include several unindexed reports, which may have not been available to many current scientists and health care personnel. Results: Foci of EPF have been described in several Central American and South American countries, affecting predominately young people and Amerindians, with an additional female predilection. Although most cases have occurred in Brazil, some cases have been reported in Peru, Paraguay, El Salvador, and Venezuela. Another variant of EPF has been described in El Bagre, Colombia, affecting older men and a few post-menopausal females. Finally, another type of EPF was described in nomadic tribes affecting females of child bearing age in Tunisia, Africa. Conclusion: Our understanding of EPF has been hampered by a lack of government attention to these diseases, especially in some South and Central American countries. Other factors that have made past studies of EPF difficult include 1) that the disease foci are often located in rural areas bordering the rain forest of underdeveloped countries; and 2) military conflicts in some of these areas.
Nurse-led clinics as an effective service for cardiac patients: results from a systematic review.

AIM The article summarises results of a systematic review on the effectiveness of nurse-led clinics for patients with coronary heart disease. The objective was to present the best available evidence related to effective interventions in nurse-led cardiac clinics including patient education, risk factor assessment and continuity of care. METHODS Following the principles of the Cochrane Collaboration for systematic reviews on effectiveness, this is an update to a previously published review. Thirty databases, relevant journals and hand searching of reference lists were the basis for a comprehensive literature search for the period September 2002 to March 2008. Assessment of methodological quality, data extraction and synthesis was undertaken using a systematic review management tool (JBI-SUMARI). When possible, data was pooled in a meta-analysis. RESULTS The systematic review is based on seven randomised controlled trials. Inconsistencies of interventions executed in nurse-led clinics and various effects on the outcomes make a comparison difficult. The major nurse-led intervention applied in the clinics consisted of health education, counselling behaviour change and promotion of a healthy lifestyle. There were no harmful effects on patients with coronary heart disease identified when exposed to a nurse-led clinic. A few risk factors were significantly reduced in the short term by attending nurse-led clinics, but long-term changes were less apparent. The success of modifying behaviour such as smoking cessation and diet adherence was limited. However, nurse-led clinics may positively influence perceived quality of life and general health status. CONCLUSION The results indicated that care was equivalent to non-nurse-managed clinics, and there was no greater risk of poorer outcomes in the nurse-led clinics. The effectiveness of clinics might be dependent on the intensity of the nursing support. Before establishing a nurse-led clinic appropriate qualification and responsibilities, as well as the particular structure of the healthcare system and funding possibilities have to be considered. The combination of counselling and regular assessment of risk factors and health status delivered at nurse-led clinics is supported by the available research, and given that outcomes were in general equivalent between nurse-led and other clinics, further research should investigate the cost-effectiveness of the different models of care.