Miracle-dz/UniFAR-FTUs huggingface dataset:
Fluctuations of tidewater glaciers in Hornsund Fjord (Southern Svalbard) since the beginning of the 20th century

Significant retreat of glaciers terminating in Hornsund Fjord (Southern Spits− bergen, Svalbard) has been observed during the 20 th century and in the first decade of the 21 st century. The objective of this paper is to present, as complete as possible, a record of front positions changes of 14 tidewater glaciers during this period and to distinguish the main factors influencing their fluctuations. Results are based on a GIS analysis of archival maps, field measurements, and aerial and satellite images. Accuracy was based on an as− sessment of seasonal fluctuations of a glacier's ice cliff position with respect to its mini− mum length in winter (November-December) and its maximum advance position in June or July. Morphometric features and the environmental setting of each glacier are also pre− sented. The total area of the glacier cover in Hornsund Fjord in the period of 1899-2010 diminished approximately 172 km 2 , with an average areal retreat rate of 1.6 km 2 a −1 . T he recession rate increased from ~1 km 2 a −1 in first decades of the 20 th century up to ~3 km 2 a −1 in years 2001-2010. The latest period was more thoroughly studied using optical satellite images acquired almost every year. The importance of glacier morphology and hypso− metry, as well as fjord bathymetry and topography is analyzed. Large glacier systems with low slopes terminating in deeper waters are retreating faster than small steep glaciers ter− minating in shallower water. A relation between mean annual air temperature and aerial retreat rate of tidewater glaciers was found for long time scales. A sudden temperature in− crease, known as the early 20 th century warming in Svalbard, and an increase in tempera− tures during recent decades are well reflected in deglaciation rate. Influence of sea water temperatures on calving and retreat of glaciers was considered and is significant in short−time intervals of the last decade. Surge events are non−climatic factors which com− plicate the record. They are reflected in front advance or fast retreat due to a massive calv− ing depending on the relation between ice thickness and water depth. Despite the influ− ence of many factors, the response of tidewater glaciers to climate change is evident. The average linear retreat rate of all the tidewater glaciers in Hornsund amounted to ~70 ma −1 in 2001-2010 and was higher than the average retreat of other Svalbard tidewater glaciers (~45 ma −1 ). Thus, glaciers of this basin can be considered as more sensitive to climate than glaciers of other regions of the archipelago.
The cyclin-dependent kinase inhibitor flavopiridol (alvocidib) inhibits metastasis of human osteosarcoma cells

Osteosarcoma is the most common primary malignant neoplasm of bone and typically occurs in children and young adults. As a highly metastatic malignancy, 15–20% of osteosarcoma patients are diagnosed after the tumor has already metastasized (typically to the lungs), which translates to 5-year survival rates of <40%. Here, we tested the effect of the cyclin-dependent kinase (CDK) inhibitor flavopiridol (alvocidib) in U2OS, SaOS-2, SJSA-1, and 143B osteosarcoma tumor cells in vitro and in vivo. Our results show that flavopiridol can drastically decrease survival in these osteosarcoma cell lines at nanomolar concentrations and induce mitotic catastrophe in p53-null osteosarcomas. We also performed transcriptome analysis (RNA-seq) of flavopiridol-treated osteosarcoma cells, which revealed significant changes in genes coding for proteins involved in cell-cell and cell-matrix adhesions, including cadherin 3 (CDH3) and 4 (CDH4). These transcriptional changes translated to a striking reduction in the ability of osteosarcoma cells to migrate and invade in vitro. Further, in vivo assessment of the effects of flavopiridol on osteosarcoma metastasis resulted in a significant reduction in the number of lung metastases in mice treated with flavopiridol at concentrations that are physiologically tolerable. This study suggests that flavopiridol, likely in combination with other cytotoxic chemotherapeutic agents, may be a promising drug for the treatment of osteosarcoma.
Protein Deiminase 4 and CR3 Regulate Aspergillus fumigatus and β-Glucan-Induced Neutrophil Extracellular Trap Formation, but Hyphal Killing Is Dependent Only on CR3

Neutrophil extracellular trap (NET) formation requires chromatin decondensation before nuclear swelling and eventual extracellular release of DNA, which occurs together with nuclear and cytoplasmic antimicrobial proteins. A key mediator of chromatin decondensation is protein deiminase 4 (PAD4), which catalyzes histone citrullination. In the current study, we examined the role of PAD4 and NETosis following activation of neutrophils by A. fumigatus hyphal extract or cell wall β-glucan (curdlan) and found that both induced NET release by human and murine neutrophils. Also, using blocking antibodies to CR3 and Dectin-1 together with CR3-deficient CD18−/− and Dectin-1−/− murine neutrophils, we found that the β-glucan receptor CR3, but not Dectin-1, was required for NET formation. NETosis was also dependent on NADPH oxidase production of reactive oxygen species (ROS). Using an antibody to citrullinated histone 3 (H3Cit) as an indicator of PAD4 activity, we show that β-glucan stimulated NETosis occurs in neutrophils from C57BL/6, but not PAD4−/− mice. Similarly, a small molecule PAD4 inhibitor (GSK484) blocked NET formation by human neutrophils. Despite these observations, the ability of PAD4−/− neutrophils to release calprotectin and kill A. fumigatus hyphae was not significantly different from C57BL/6 neutrophils, whereas CD18−/− neutrophils exhibited an impaired ability to perform both functions. We also detected H3Cit in A. fumigatus infected C57BL/6, but not PAD4−/− corneas; however, we found no difference between C57BL/6 and PAD4−/− mice in either corneal disease or hyphal killing. Taken together, these findings lead us to conclude that although PAD4 together with CR3-mediated ROS production is required for NET formation in response to A. fumigatus, PAD4-dependent NETosis is not required for A. fumigatus killing either in vitro or during infection.
Profiling the Urinary Microbiota in Male Patients With Bladder Cancer in China

Mounting evidence indicates that microbiome plays an important role in the development and progression of cancer. The dogma that urine in healthy individuals must be sterile has been overturned. Dysbiosis of the urinary microbiome has been revealed responsible for various urological disorders, including prostate cancer. The link between chronic inflammation, microbiome and solid tumors has been established for various neoplastic diseases. However, a detailed and comprehensive analysis of urinary microenvironment of bladder cancer has not been yet reported. We performed this study to characterize the potential urinary microbial community possibly associated with bladder cancer. Mid-stream urine was collected from 31 male patients with bladder cancer and 18 non-neoplastic controls. DNA was extracted from urine pellet samples and processed for high throughput 16S rRNA amplicon sequencing of the V4 region using Illumina MiSeq. Sequencing reads were filtered using QIIME and clustered using UPARSE. We observed increased bacterial richness (Observed Species, Chao 1 and Ace indexes; cancer vs. control; 120.0 vs. 56.0; 134.5 vs. 68.3; and 139.6 vs. 72.9, respectively), enrichment of some bacterial genera (e.g., Acinetobacter, Anaerococcus, and Sphingobacterium) and decrease of some bacterial genera (e.g., Serratia, Proteus, and Roseomonas) in cancer group when compared to non-cancer group. Significant difference in beta diversity was found between cancer and non-cancer group, among different risk level, but not among different tumor grade. Enrichment of Herbaspirillum, Porphyrobacter, and Bacteroides was observed in cancer patients with high risk of recurrence and progression, which means these genera maybe potential biomarkers for risk stratification. The PICRUSt showed that various functional pathways were enriched in cancer group, including Staphylococcus aureus infection, glycerolipid metabolism and retinol metabolism. To our knowledge, we performed the most comprehensive study to date to characterize the urinary microbiome associated with bladder cancer. A better understanding of the role of microbiome in the development and progression of bladder cancer could pave a new way for exploring new therapeutic options and biomarkers.
Predictors of surgical outcomes and survival in rectal cancer patients undergoing laparoscopic total mesorectal excision after neoadjuvant chemoradiation therapy: the interest of pelvimetry and restaging magnetic resonance imaging studies

Background Locally advanced rectal cancer (LARC) requires a multimodal therapy tailored to the patient and tumor characteristics. Pretreatment magnetic resonance imaging (MRI) is necessary to stage the primary tumor, while restaging MRI, which is not systematically performed, may be of interest to identify poor responders to neoadjuvant chemoradiation therapy (NCRT), and redefine therapeutic approach. The EuMaRCS study group aimed to investigate the role and accuracy of pretreatment (including pelvimetry) and restaging MRIs in predicting surgical difficulties and surgical outcomes in LARC therapy. Methods Patients with mid or low LARC who were administered NCRT, who underwent laparoscopic total mesorectal excision, and for whom pretreatment and restaging MRIs were available, were included. Results MRIs of 170 patients (median age: 61 years) were reanalyzed by the same radiologist. Pelvimetry differed significantly between males and females, but no gender difference was noted in the clinical and tumor characteristics. Tumor volume and tumor height assessed on the restaging MRI were associated, respectively, with operative time and estimated blood loss. Conversion was predicted by tumor volume, interischial distance and pubic tubercle height. The quality of the surgical resection was found to be a predictor of overall and disease-free survival. The sensitivity and specificity of tumor regression grade 1 to identify a pathologic complete response were 76.9% and 89.3%, respectively. Conclusions In LARC management, pelvimetry and restaging MRI may be useful to predict surgical difficulties and surgical outcomes. However, the main independent predictor of patient survival appears to be the achievement of a successful surgical resection.
Area of and volume enclosed by digital and triangulated surfaces

We demonstrate that the volume enclosed by triangulated surfaces can be computed efficiently in the same elegant way the volume enclosed by digital surfaces is computed by digital surface integration. Although digital surfaces are good for visualization and volume measurement, their drawback is that surface area measurements are inaccurate. On the other hand, triangulated surfaces give more accurate surface area measurements, but volume measurements and visualization are less efficient. The T-shell data structure previously proposed retains advantages and overcomes difficulties of both the digital and the triangulated approaches. We create a lookup table with area and volume contributions for each of the 256 Marching Cubes configurations. When scanning the shell (e.g., while creating it), the surface area and volume are incrementally computed by using the lookup table and the current x co-ordinate, where the sign of the x component of the triangle normal indicates the sign of the volume contribution. We have computed surface area and volume for digital and triangulated surfaces for digitized mathematical phantoms, physical phantoms, and real objects. The computations show that triangulated surface area is more accurate, triangulated volume follows digital volume closely, and that the values get closer to the true value with decreasing voxel size.
The Dynamics of Mobile Learning Utilization in Vocational Education: Frame Model Perspective Review.

This study aimed to describe the dynamics of content aspects, user aspects and social aspects of mobile learning utilization (m-learning) in vocational education from the FRAME Model perspective review. This study was quantitative descriptive research. The population in this study was teachers and students of state vocational school and private school in Makassar, Indonesia. Samples of the study were 103 teachers and 320 students, determined by a proportional random sampling technique. Data collection techniques were questionnaires. Data analysis uses descriptive analysis techniques. The results showed that the available content on the internet and accessed by teachers were relevant to the major, whereas students stated them relevantly less to their majors, so the value and substance of the utilization of m-learning content were still less relevant. The user aspect showed that teachers and students utilized mobile devices for vocational learning purposes, so the value and substance of m-learning could be still maintained. The social aspect showed that teachers and students expressed sociocultural support influenced the utilization of m-learning, so that the value and substance of m-learning in vocational education could be continually maintained. So the value and substance of m-learning in these three aspects could be maintained and improved, this study showed alternative model of utilization and development of m-learning that were appropriate for vocational education.
Recent advances in the understanding and management of cystic fibrosis pulmonary exacerbations

Pulmonary exacerbations are common events in cystic fibrosis and have a profound impact on quality of life, morbidity, and mortality. Pulmonary exacerbation outcomes remain poor and a significant proportion of patients fail to recover their baseline lung function despite receiving aggressive treatment with intravenous antibiotics. This focused review provides an update on some of the recent advances that have taken place in our understanding of the epidemiology, pathophysiology, diagnosis, and management of pulmonary exacerbations in cystic fibrosis as well as direction for future study.
Quantum Advantage from Conjugated Clifford Circuits

A well-known result of Gottesman and Knill states that Clifford circuits - i.e. circuits composed of only CNOT, Hadamard, and $\pi/4$ phase gates - are efficiently classically simulable. We show that in contrast, "conjugated Clifford circuits" (CCCs) - where one additionally conjugates every qubit by the same one-qubit gate U - can perform hard sampling tasks. In particular, we fully classify the computational power of CCCs by showing that essentially any non-Clifford conjugating unitary U can give rise to sampling tasks which cannot be simulated classically to constant multiplicative error, unless the polynomial hierarchy collapses. Furthermore, we show that this hardness result can be extended to allow for the more realistic model of constant additive error, under a plausible complexity-theoretic conjecture.
The Effect of Single and Multiple SERAT Mutants on Serine and Sulfur Metabolism

The gene family of serine acetyltransferases (SERATs) constitutes an interface between the plant pathways of serine and sulfur metabolism. SERATs provide the activated precursor, O-acetylserine for the fixation of reduced sulfur into cysteine by exchanging the serine hydroxyl moiety by a sulfhydryl moiety, and subsequently all organic compounds containing reduced sulfur moieties. We investigate here, how manipulation of the SERAT interface results in metabolic alterations upstream or downstream of this boundary and the extent to which the five SERAT isoforms exert an effect on the coupled system, respectively. Serine is synthesized through three distinct pathways while cysteine biosynthesis is distributed over the three compartments cytosol, mitochondria, and plastids. As the respective mutants are viable, all necessary metabolites can obviously cross various membrane systems to compensate what would otherwise constitute a lethal failure in cysteine biosynthesis. Furthermore, given that cysteine serves as precursor for multiple pathways, cysteine biosynthesis is highly regulated at both, the enzyme and the expression level. In this study, metabolite profiles of a mutant series of the SERAT gene family displayed that levels of the downstream metabolites in sulfur metabolism were affected in correlation with the reduction levels of SERAT activities and the growth phenotypes, while levels of the upstream metabolites in serine metabolism were unchanged in the serat mutants compared to wild-type plants. These results suggest that despite of the fact that the two metabolic pathways are directly connected, there seems to be no causal link in metabolic alterations. This might be caused by the difference of their pool sizes or the tight regulation by homeostatic mechanisms that control the metabolite concentration in plant cells. Additionally, growth conditions exerted an influence on metabolic compositions.
Prevalence, awareness, treatment, control, and risk factors of hypertension among adults: a cross-sectional study in Iran

OBJECTIVES Hypertension (HTN) is an important risk factor for cardiovascular disease. Considering the importance of this disease for public health, this study was designed in order to determine the prevalence, awareness, treatment, control, and risk factors of HTN in the Iranian adult population. METHODS This cross-sectional study was conducted among 2,107 residents of Isfahan, Iran. Samples were selected through multi-stage random cluster sampling in 2015-2016. The outcome variable was HTN, determined by measuring blood pressure in the right arm via a digital arm blood pressure monitor. Awareness, treatment, and control of HTN were assessed by a validated and reliable researcher-developed questionnaire. Other demographic and clinical variables were assessed via a demographic questionnaire. RESULTS The overall prevalence of HTN was 17.3% (18.9 and 15.5% in men and women, respectively). The prevalence of HTN increased in both genders with age. The prevalence of awareness of HTN among people with HTN was 69.2%, of whom 92.4 and 59.9% were taking medication for HTN and had controlled HTN, respectively. Logistic regression identified age, body mass index, having diabetes and hyperlipidemia, and a positive family history of HTN as determinants of awareness of HTN. CONCLUSIONS The results showed that HTN was highly prevalent in the community, especially in men and in middle-aged and older adults. Approximately 30.8% of patients were unaware of their disease, and there was less awareness among younger adults. Despite the high frequency of taking medication to treat HTN, it was uncontrolled in more than 40.1% of patients. Health policy-makers should therefore consider appropriate preventive and therapeutic strategies for these high-risk groups.
EVOLUTIONARY RELATIONSHIP OF NUCLEAR GENES ENCODING MITOCHONDRIAL PROTEINS ACROSS FOUR GRASS SPECIES AND ARABIDOPSIS THALIANA

Comparative genomics studies across taxa provide basic understanding of genome evolution. This study focused on nuclear genes encoding mitochondrial proteins across Arabidopsis and several grass species. Two different mitochondria-related gene sets, one rice-de- rived and another Arabidopsis-derived, were used in our analysis. Eleven of the rice-derived genes, from a 6.85 Mb region of chromosome 10, were physically mapped using radiation hybrid (RH) approach on chromosome 1D of wheat. Based on the comparative analysis of these 11 genes, genomes of wheat and maize shared more compa- rable pattern of conservation than wheat and rice. Addi- tionally, rice, revealed to have perfectly conserved colin- earity with Brachypodium, whereas, wheat and Brachy- podium showed less preserved synteny. This was surpris- ing since previous studies have estimated that Brachy- podium was evolutionarily closer to wheat than rice when comparing their divergence times. Some rearrangements in studied regions of wheat and maize genomes may indi- cate a relaxation of evolutionary pressure on gene order in polyploid as compared with diploid species. Addition- ally, our cluster analysis on chromosome 10 of rice identi- fied two mitochondria-related gene clusters, one contain- ing seven and another one two genes. Analysis of Ara- bidopsis-derived set of 473 genes showed 14 to 16% con- servation in rice, maize, Brachypodium, and wheat. Forty five genes showed to be conserved in representatives of monocots as well as in Arabidopsis which underlies the significance of their conservation for survival of plant mi- tochondria. Moreover, observed clustering of the mito- chondria-related nuclear genes on chromosome 10 of rice indicates that the gene clustering might be one of the ways to preserve crucial genes from major rearrange- ments or recombination events that could compromise their function.
Deep Generative Models for Distribution-Preserving Lossy Compression

We propose and study the problem of distribution-preserving lossy compression. Motivated by recent advances in extreme image compression which allow to maintain artifact-free reconstructions even at very low bitrates, we propose to optimize the rate-distortion tradeoff under the constraint that the reconstructed samples follow the distribution of the training data. The resulting compression system recovers both ends of the spectrum: On one hand, at zero bitrate it learns a generative model of the data, and at high enough bitrates it achieves perfect reconstruction. Furthermore, for intermediate bitrates it smoothly interpolates between learning a generative model of the training data and perfectly reconstructing the training samples. We study several methods to approximately solve the proposed optimization problem, including a novel combination of Wasserstein GAN and Wasserstein Autoencoder, and present an extensive theoretical and empirical characterization of the proposed compression systems.
Tetrahedral meshing in the wild

We propose a novel tetrahedral meshing technique that is unconditionally robust, requires no user interaction, and can directly convert a triangle soup into an analysis-ready volumetric mesh. The approach is based on several core principles: (1) initial mesh construction based on a fully robust, yet efficient, filtered exact computation (2) explicit (automatic or user-defined) tolerancing of the mesh relative to the surface input (3) iterative mesh improvement with guarantees, at every step, of the output validity. The quality of the resulting mesh is a direct function of the target mesh size and allowed tolerance: increasing allowed deviation from the initial mesh and decreasing the target edge length both lead to higher mesh quality. Our approach enables "black-box" analysis, i.e. it allows to automatically solve partial differential equations on geometrical models available in the wild, offering a robustness and reliability comparable to, e.g., image processing algorithms, opening the door to automatic, large scale processing of real-world geometric data.