Miracle-dz/UniFAR-FTUs huggingface dataset:
THE DERIVED MCKAY CORRESPONDENCE IN DIMENSION 2

When I first started in algebraic geometry, my first task was to understand the proof of the derived McKay correspondence (Theorem 1.1 below) in order to become more familiar with the foundations of my interests. At the time I knew only a little representation theory (mostly of Lie algebras), could give the definition and sketch of the construction of the Hilbert scheme, and knew only vague generalities about derived categories of sheaves. To remedy this I began to take notes on what I read (as I find this is to be very helpful for both understanding and recollection); and at the encouragement of a few others I put them together in this note for people to read at their leisure. These notes also help fill a gap which I found disturbingly present throughout the literature. Namely the subject of equivariant derived categories and their most famous application (the derived McKay correspondence) is alluded to in many sources, but no introductory account of the proof (at least for C) seems to exist. This material seems to be well known among experts, but has no discussion in the literature besides very general accounts ([2]). As such I decided to make this available with the goal of revealing as many secrets of the trade as I was able, assuming only basic algebraic geometry at the level of Hartshorne’s text [20]. Hopefully I have managed that much. It should be clear that none of the following is original work, merely the contribution has only been to collect the pieces scattered throughout the literature and assemble them into a (hopefully readable) exposition.
Retina Regional Patterns of Retinal Oxygen Saturation and Microvascular Hemodynamic Parameters Preceding Retinopathy in Patients With Type II Diabetes

Julia Hafner, Laurin Ginner, Sonja Karst, Rainer Leitgeb, Michael Unterluggauer, Stefan Sacu, Christoph Mitsch, Christoph Scholda, Eleonore Pablik, and Ursula Schmidt-Erfurth Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria Center of Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria Christian Doppler Laboratory for Innovative Optical Imaging and its Translation to Medicine, Medical University of Vienna, Vienna, Austria CeMSIIS, Institute for Medical Statistics, Medical University of Vienna, Vienna, Austria
Incorporating InStream Nutrient Uptake into River Management : Gipuzkoa Rivers ( Basque Country , North Spain ) as a Case Study

Gipuzkoa (Basque Country, North Spain) is an industrial region where investments in sanitation and wastewater treatment have improved water quality and partially recovered river biological communities. However, further technological improvements are unlikely. Our objective was to assess whether in-stream self-purification may contribute to improvement of the trophic state of rivers. We propose an integrative approach to assessing river water quality, which diagnoses problems, identifies likely causes and prescribes solutions. We first analysed the loads of nutrients transported by Gipuzkoa rivers and compared them with the potential nutrient uptake rates (estimated from published empirical regressions). In reaches where both of them were within one order of magnitude, we considered that the self-purification capacity of river channels may influence nutrient concentrations. Then, we selected some river reaches where no other water quality problems beyond nutrient concentrations occurred and ran the expert system STREAMES 1.0 to diagnose the problems and detect their causes. The studied reaches differed in their problems and in their potential solutions. We empirically determined nutrient retention in two streams by means of mass balances and slug nutrient additions. We detected large differences in retention capacity between reaches and siltation as one of the main problems affecting the self-purification capacity of the study streams. Finally, we used STREAMES 1.0 to identify potential solutions to specific river sections. The results obtained so far point towards an important potential of in-stream bioreactive capacity to reduce nutrient loads and to specific restoration activities that may improve the functionality and trophic status of the streams in Gipuzkoa.
Reduced Nrf2 activation in PI3K phosphorylation‐impaired vitiliginous keratinocytes increases susceptibility to ROS‐generating chemical‐induced apoptosis

Keratinocytes in affected epidermis of vitiligo patients are known to have impaired activation of the PI3K/AKT pathway. Based on critical roles of keratinocytes and oxidative stress in vitiligo development, this study examined whether keratinocytes with impaired PI3K activation were more vulnerable to apoptosis caused by oxidative stress from phenolic compounds, p‐tert‐butylphenol (4‐TBP) and hydroquinone (HQ). Cell viability assay, FACS analysis, ELISA for TNF‐α or IL‐1a, ROS assay, Western blot analysis for Nrf2 expression, and confocal microscopy with anti‐Nrf2 and phospho‐PI3K antibodies were done on primary cultured normal human keratinocytes with or without PI3K knockdown in the presence or absence of chemical treatment or antioxidant. Immunofluorescence staining using anti‐Nrf2, phospho‐PI3K, TNF‐ɑ, and IL‐1ɑ antibodies, ROS assay using dihydroethidium, and TUNEL assay were performed on sets of depigmented and normally pigmented skin from vitiligo patients. Results showed that 4‐TBP or HQ treatment increased apoptosis and the expression levels of TNF‐ɑ, IL‐1ɑ, and ROS in PI3K‐knockdown keratinocytes which reduced Nrf2 nuclear translocation compared to control keratinocytes. These changes were significantly recovered by an antioxidant treatment. Depigmented epidermis of vitiligo patients also showed lower levels of Nrf2 and phospho‐PI3K but higher levels of ROS, TNF‐ɑ, IL‐1ɑ, and ROS with more TUNEL‐positive cells. Therefore, impaired PI3K activation in keratinocytes in depigmented epidermis of vitiligo patients are vulnerable to apoptosis caused by ROS‐generating chemicals due to reduced Nrf2 activation.
SOL-GEL/HYDROTHERMAL SYNTHESIS OF MIXED METAL OXIDE OF TITANIUM AND ZINC (TiO /ZnO) NANOCOMPOSITES THROUGH DIRECT

Mixed metal oxides of titanium and zinc nanocomposites were prepared through sol-gel method under hydrothermal condition using titanium oxy-(1, 2 pentadione) and zinc acetate without hazardous additives. The resulting composites were characterized by X-Ray Diffractometer (XRD), Scanning Electron Microscope (SEM) and the optical property was determined from the ultraviolet/visible spectrum. The reactions were
Aalborg Universitet Does a tow-bar increase the risk of neck injury in rear-end collisions ?

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Glycaemic efficacy of glucagon‐like peptide‐1 receptor agonists and dipeptidyl peptidase‐4 inhibitors as add‐on therapy to metformin in subjects with type 2 diabetes—a review and meta analysis

Aims: During recent years, two strategies of incretin‐based therapy [glucagon‐like peptide‐1 (GLP‐1) receptor agonism and dipeptidyl peptidase‐4 (DPP‐4) inhibition] have entered the market for pharmacological management of type 2 diabetes. A main indication for this therapy is as add‐on to on‐going metformin therapy in subjects with type 2 diabetes who have insufficient glycaemic control with metformin alone. The aim of this study was to compare improvements in glycaemic control and changes in body weight, as well as adverse events, in comparable studies with incretin‐based therapy as add‐on to metformin.
Market power across the Channel: Are Continental European gas markets isolated ?

This paper examines the efficiency of the arbitrages performed between two regional markets for wholesale natural gas linked by a capacity-constrained pipeline system. We develop a switching regime specification to (i) detect if the observed spatial arbitrages satisfy the integration notion that all arbitrage opportunities between the two markets are being exploited, and (ii) decompose the observed spatial price differences into factors such as transportation costs, transportation bottlenecks, and the oligopolistic behavior of the arbitrageurs. Our framework incorporates a test for the presence of market power and it is thus able to distinguish between the physical and behavioral constraints to marginal cost pricing. We use the case of the “Interconnector” pipeline as an application, linking Belgium and the UK. Our empirical findings show that all the arbitrage opportunities between the two zones are being exploited but confirm the presence of market power.
Area prioritization for insect pollinator communities on an Oceanic Island

Conservation studies usually assess the effectiveness of protected areas and draft proposals on the inclusion of new areas to gain legal protection status, paying little attention to the unprotected surrounding matrix of the respective protected areas network. By combining species distribution modeling and a site selection method, we aim to quantify the contribution of different land uses to insect pollinator conservation on a small oceanic island i.e. Terceira Island (Azores, Portugal). Our results showed that, in addition to well preserved and protected native forest in Terceira, other land uses, such as naturalized vegetation areas, exotic forests, and semi-natural pastures, could serve as a continuum for the protected areas network. This result suggests that protecting marginal non-natural areas may also be important, especially when areas with wellpreserved natural habitats are scarce. This spatial planning approach can be easily applied to other islands in the archipelago and any similar island systems, to better plan conservation efforts (such as habitat restoration) and to design specific buffer zones around a protected areas network.
SCREENED POISSON FOR PHOTOREALISTIC STYLE TRANSFER 3 seems like the use of deep feature space in order to transfer image properties gives a notable gain in this task

Recent work has shown impressive success in transferring painterly style to images. These approaches, however, fall short of photorealistic style transfer. Even when both the input and reference images are photographs, the output still exhibits distortions reminiscent of a painting. In this paper we propose an approach that takes as input a stylized image and makes it more photorealistic. It relies on the Screened Poisson Equation, maintaining the fidelity of the stylized image while constraining the gradients to those of the original input image. Our method is fast, simple, fully automatic and shows positive progress in making a stylized image photorealistic. Our results exhibit finer details and are less prone to artifacts than the state-of-the-art.
Egg of the Karner Blue butterfly (Lycaeides melissa samuelis): Morphology and elemental analysis

Most insect eggshells are ornately sculptured; that of the Karner Blue butterfly, Lycaeides melissa samuelis, exhibits a series of interwoven ridges and depressions. Scanning electron microscopic views of the shell show that the patterning resides in the outer chorion, while the inner vitelline membrane is relatively flat and featureless. We here describe the morphology of the egg and introduce a physical technique, use of a Dynamitron accelerator, to identify and localize elements in the eggshell. Most elements present are represented in the chorion, but sulfur appears restricted to the vitelline membrane. The micropyle is particularly rich in calcium and, in unhatched eggs, phosphorus as well. J. Morphol. 251:140–148, 2002. © 2002 Wiley‐Liss, Inc.
Contribution of Fas to diabetes development

Fas (Tnfrsf6, Apo-1, CD95) is a death receptor involved in apoptosis induced in many cell types. Fas have been shown to be expressed by insulin-producing beta cells in mice and humans. However, the importance of Fas in the development of autoimmune diabetes remains controversial. To further evaluate the importance of Fas in pathogenesis of diabetes, we generated NOD mice (nonobese diabetic mice developing spontaneous autoimmune diabetes) with beta cell-specific expression of a dominant-negative point mutation in a death domain of Fas, known as lprcg or Fascg. Spontaneous diabetes was significantly delayed in NOD mice expressing Fascg, and the effect depended on the expression level of the transgene. However, Fascg-bearing mice were still sensitive to diabetes transferred by splenocytes from overtly diabetic NOD mice. At the same time, Fascg expression did neutralize the accelerating effect of transgenic Fas-ligand expressed by the same beta cells. Thus, both Fas-dependent and -independent mechanisms are involved in beta cell destruction, but interference with the Fas pathway early in disease development may retard or prevent diabetes progression.
Relationship Between Decrements in Glucose Level and Metabolic Response to Hypoglycemia in Absence of Counterregulatory Hormones in the Conscious Dog

To determine the relationship between decreases in glucose and metabolic regulation in the absence of counterregulatory hormones, we infused overnight-fasted, conscious, adrenalectomized dogs (lacking cortisol and EPI) with somatostatin (to eliminate glucagon and growth hormone) and intraportal insulin (30 pmol · kg−1 · min−1), creating arterial insulin levels of ∼2000 pM. Glucose was infused during one 120-min period, two 90-min periods, and one 45-min period to establish levels of 5.9 ± 0.1, 3.4 ± 0.1, 2.5 ± 0.1, and 1.7 ± 0.1 mM, respectively. NE levels were 1.24 ± 0.23, 1.85 ± 0.27, 2.04 ± 0.26, and 2.50 ± 0.20 nM, respectively. During the euglycemic control period, the liver took up glucose (7.5 ± 1.9 μmol · kg−1 · min−1), but hypoglycemia triggered successively greater rates of net hepatic glucose output (3.0 ± 0.7, 4.6 ± 0.9, and 6.9 ± 1.4 μmol · kg−1 · min−1). Total gluconeogenic precursor uptake by the liver increased with hypoglycemia. Intrahepatic gluconeogenic efficiency rose progressively (by 106 ± 42,199 ± 56, and 268 ± 55%). Both glycerol and NEFA levels rose, indicating lipolysis was enhanced. Net hepatic NEFA uptake and ketone production increased proportionally, but the ketone level rose only with severe hypoglycemia. In conclusion, despite marked hyperinsulinemia and the absence of glucagon, EPI, and cortisol, we observed that lipolysis and glucose and ketone production increase in response to decreases in glucose. This suggests that neural and/or autoregulatory mechanisms can play a role in combating hypoglycemia.
Normal Conjunctival Flora in the North American Opossum (Didelphis virginiana) and Raccoon (Procyon lotor)

We documented the normal conjunctival bacterial flora from 17 opossums (Didelphis virginiana) and 10 raccoons (Procyon lotor) trapped in Manhattan, Kansas (USA) from November 1999 to January 2000. Both raccoons and opossums were free of apparent ocular disease. The inferior conjunctival sacs of each animal were swabbed for aerobic bacterial and Mycoplasma culture and polymerase chain reaction (PCR) for Mycoplasma and Chlamydia detection. All conjunctival samples were positive for one or more species of aerobic bacteria. The most common isolate from opossums was Staphylococcus spp. Other isolates included Streptococcus spp. , Bacillus spp. , Corynebacterium spp. , and Enterococcus faecalis. The most common isolate in raccoons was Bacillus spp. Other isolates included Streptococcus spp. , Staphylococcus spp. , non-hemolytic Escherichia coli, and Enterococcus faecalis. Mycoplasma culture was negative in samples from opossums and raccoons. Evidence of Mycoplasma and Chlamydia presence was detected by PCR.
Chaotic Hopfield Neural Network Swarm Optimization and Its Application

A new neural network based optimization algorithm is proposed. The presented model is a discrete-time, continuous-state Hopfield neural network and the states of the model are updated synchronously. The proposed algorithm combines the advantages of traditional PSO, chaos and Hopfield neural networks: particles learn from their own experience and the experiences of surrounding particles, their search behavior is ergodic, and convergence of the swarm is guaranteed. The effectiveness of the proposed approach is demonstrated using simulations and typical optimization problems.
A Comparative Study of Thyroid Function in Non-Severe and Severe Preeclampsia in a Hospital Based Study in Manipur

DOI: 10.21276/sjams.2018. 6.1. 45 Abstract: Several studies from different parts of India reported increased TSH in preeclampsia and variable FT3 and FT4 levels. Also, the association between thyroid hormones and severity of preeclampsia are less well studied. This case control study aims to measure thyroid hormones level in non-severe and severe preeclampsia in RIMS, Manipur on 45 diagnosed case of preeclampsia and 46 healthy normotensive pregnant women in the age group of 18-40 years and >20 weeks gestation. Preeclamptic women were grouped as non-severe (n=23) and severe (n=22). Thyroid hormone assay was done by ELISA. Comparison was done by unpaired t-test and correlation by Pearson correlation test. A p-value less than 0.05 were considered significant. The TSH level in severe preeclampsia (6.49±3.24) compared to non-severe preeclampsia (4.46±2.71)(p=0.02) was significantly higher and FT4 (0.80±0.31 vs 1.09±0.53)(p=0.02) was significantly lower in severe preeclampsia. FT3 (1.61±0.82 vs 1.82±0.90) (p=0.43) of severe preeclampsia was non-significantly lower compared to non-severe preeclampsia. The TSH level in preeclamptic patients were significantly higher (5.50 ± 3.12 mIU/L) compared to normotensive pregnancy (2.03 ± 0.78 mIU/L)(p=0.0001). FT4 (0.94 ± 0.45ng/dl, 0.94 ± 0.34 ng/dl) (p=0.99) showed no change in preeclampsia and FT3 (1.71 ± 0.86 pg/ml, 1.73 ± 0.83 pg/ml) (p=0.92) was non-significantly lower in preeclampsia compared to normal pregnancy. This suggests the role of TSH in the pathogenesis and development of severity of preeclampsia. Early detection of thyroid abnormalities may help in better management of the disease in established preeclamptic women.
PUB TYPE EDRS PRICE DESCRIPTORS IDENTIFIERS DOCUMENT RESUME SP 022 210

This paper is focused on a relatively new emphasis in educalion research: the nature of academic work contained in the currirUlum of elementary and secondary schools, how that work is organized and accomplished in classrooms, and what modifigations in academic work are likely to increase student achievement. The paper is divided into two major sections. The first section is devoted to an analysis of the intellectual demands inherent in different forms of academic work. Of special importance in this section is the recent work on cognitive processes which underlie school tasks. The second section is directed to studies of how academic work is carried on in classroom environments. Particular attention in this section is given to the ways in which social and evaluative conditions in classrooms affect students' reactions to wbrk. Each section contains an analysis of implications for improving the quality of academic work in classrooms and thus increasing student achievement. Also present is an extensive bibliography (21 pages). (JM) *********************************************************************** * Reproductions supplied by EDRS are the best that can be made * from the original document. * *********************************************************************** This publication was prepared with funding from the U.S. hepartment of ECoication, under contrac Contractors undertaking such projects under government sponsorship are encouraged to express freely their judgement in professional and technical matters. Points of view or opinions do not necessarily represent those of the U.S. Department of Education.
Publication information Ninth International Workshop on Large-Scale Integration of Wind Power into Power Systems as well as on Transmission Networks for Offshore Wind Plants, Québec

Title Analysis of the voltage control capability of energy harvesting networks Authors(s) Cuffe, Paul; Smith, Paul; Keane, Andrew Publication date 2010-10 Publication information Ninth International Workshop on Large-Scale Integration of Wind Power into Power Systems as well as on Transmission Networks for Offshore Wind Plants, Québec City,Québec, Canada, 18-19 October Conference details Paper presented at the 9th International Workshop on Large-Scale Integration of Wind Power into Power Systems, 18-19 October 2010, Québec, Canada Publisher Energynautics Item record/more information http://hdl.handle. net/10197/3277
Frequency, Impedance Characteristics and HF Converters of Two-Coil and Four-Coil Wireless Power Transfer

Magnetically coupled wireless power transfer (WPT) can be roughly divided into two kinds of inductively coupled and strongly coupled magnetic resonances. In this paper, the frequency characteristics, impedance characteristics and high frequency (HF) converters of two-coil and four-coil magnetically coupled WPT are outlined between inductively coupled power transfer (ICPT) and resonant coupling WPT. First, the frequency bifurcation in ICPT and frequency splitting in resonant coupling WPT are analyzed, and the natural similarities are explained, which have not been pointed out before. Second, the differences of the conventional two-coil (often used in ICPT) and four-coil WPT are analyzed by their input impedance characteristics. The results show that the two-coil WPT is appropriate for short-range and the four-coil WPT suitable for mid-range applications. In the end, as one of the most important parts of magnetically coupled WPT systems, HF converters used in WPT systems are summarized and a new soft-switched converter is put forward, which has 70% efficiency though it is not precisely designed.
Essential Functions of C Terminus of Drosophila Topoisomerase IIIα in Double Holliday Junction Dissolution♦

Background: Topoisomerase IIIα (Top3α) and Blm dissolve Holliday junctions into non-crossover products. Results: The Top3α C terminus binds to Blm and DNA substrates and is important in vivo. Conclusion: The C-terminal domain of Top3α is required for dissolution and cellular functions. Significance: The Top3α C terminus is an essential component of the dissolvasome complex. Topoisomerase IIIα (Top3α) is an essential component of the double Holliday junction (dHJ) dissolvasome complex in metazoans, along with Blm and Rmi1/2. This important anti-recombinogenic function cannot be performed by Top3β, the other type IA topoisomerase present in metazoans. The two share a catalytic core but diverge in their tail regions. To understand this difference in function, we investigated the role of the unique C terminus of Top3α. The Drosophila C terminus contains an insert region not conserved among metazoans. This insert contributes an independent interaction with Blm, which may account for the absence of Rmi1 in Drosophila. Mutant Top3α lacking this insert maintains the ability to perform dHJ dissolution but only partially rescues a top3α null fly line, indicating an in vivo role for the insert. Truncation of the C terminus has a minimal effect on the type IA relaxation activity of Top3α; however, dHJ dissolution is greatly reduced. The Top3α C terminus was found to strongly interact with both Blm and DNA, which are critical to the dissolution reaction; these interactions are greatly reduced in the truncated enzyme. The truncation mutant also cannot rescue the viability of top3α null flies, indicating an essential in vivo role. Our data therefore suggest that the Top3α C terminus has an important role in dHJ dissolution (by providing an interaction interface for Blm and DNA) and an essential function in vivo.