Miracle-dz/UniFAR-FTUs huggingface dataset:
Insulin resistance in patients with rheumatoid arthritis: effect of anti‐TNFα therapy

Objectives: We undertook this study to test the hypotheses that patients with active rheumatoid arthritis (RA) are insulin resistant and that anti‐tumour necrosis factor‐α (TNFα) therapy improves not only the clinical state of these patients but also their glucose metabolism. Methods: Nine RA patients with active disease and nine healthy subjects, matched for sex, age, and body mass index (BMI), underwent a hyperinsulinaemic euglycaemic clamp. The RA patients received anti‐TNFα therapy with Humira®(adalimumab) and had the insulin clamp re‐evaluated after 8 weeks of treatment. Results: Patients with RA had marked insulin resistance (glucose infusion rate (GIR) area under the curve (AUC) was 499±55 mg/kg in the RA group compared to 710±77 mg/kg in the control group; p<0.05). However, insulin sensitivity did not differ before and after 8 weeks of adalimumab therapy. The RA patients demonstrated a reduction in C‐reactive protein (CRP) and interleukin‐6 (IL‐6) levels after the therapy as compared to pretreatment values, but there was no concomitant effect on plasma levels of TNFα. Conclusion: RA patients with active disease showed marked insulin resistance that was not influenced by anti‐TNFα therapy despite a reduction in systemic inflammation during the treatment.
Hypercholesterolemia Induces Side-Specific Phenotypic Changes and Peroxisome Proliferator–Activated Receptor-&ggr; Pathway Activation in Swine Aortic Valve Endothelium

Background—The endothelium of healthy aortic valves expresses different phenotypes on the aortic and ventricular sides. On the aortic side, which is susceptible to aortic valve sclerosis, there is a balanced coexpression of both propathological and protective pathways. Side-specific global gene expression can address endothelial phenotype balance in early aortic valve sclerosis. Methods and Results—Adult male swine were fed a hypercholesterolemic or an isocaloric normal diet for 2-week and 6-month periods. Hypercholesterolemia induced localized lipid insudation confined to the aortic side of the leaflet. Transcript profiling of valve endothelial populations showed that the susceptible aortic side was more sensitive to 2-week hypercholesterolemia than the ventricular side (1,325 vs 87 genes were differentially expressed). However, greater sensitivity was not evidence of a dysfunctional phenotype. Instead, pathway analyses identified differential expression of caspase 3–, peroxisome proliferator–activated receptor &ggr;–, TNF-&agr;–, and nuclear factor-&kgr;B–related pathways that were consistent with a protective endothelial phenotype. This was confirmed at the protein level at 2 weeks and persisted at 6 months. Conclusions—In a large animal model at high spatial resolution, endothelium on the pathosusceptible side of the aortic valve leaflet is responsive to hypercholesterolemia. Transcript profiles indicative of a protective phenotype were induced and persisted on the side prone to aortic valve sclerosis.
Improved off-current and subthreshold slope in aggressively scaled poly-Si TFTs with a single grain boundary in the channel

A polycrystalline-silicon thin-film transistor (TFT), with a single grain boundary (GB) present in the channel, is simulated using two-dimensional numerical simulation, which includes a model of deep trap states at GBs. It is observed that the potential barrier resulting from a GB in the channel acts to suppress current flowing through the channel when the barrier height is greater than the thermal voltage. The conduction mechanism in the subthreshold regime is clarified. The turn-on characteristics of the device are controlled primarily by gate-induced grain barrier lowering as opposed to modulation of carriers in the channel by the gate voltage. In the negative bias region it is found that suppression of the off current is aided by the GB potential barrier. Scaling of the various geometrical parameters of the device are investigated. Improved subthreshold characteristics, compared to an equivalent silicon-on-insulator (SOI) structure, are found for aggressively scaled devices, due to the presence of a GB in the channel.
In Search of the Architect of Learning

In this article, I accept Stone's invitation to reevaluate the metaphor of scaffolding, building on his helpful analysis. Specifically, I identify what has been appealing about the scaffolding metaphor by describing how, as an intervention researcher working with students with learning disabilities, I have used the metaphor to describe a specific instructional approach in my own research. Then, I revisit and critique scaffolding as an instructional metaphor. I also comment on Stone's assertion that a more explicit description of communicative interchanges is required to more clearly describe instructional scaffolding. Finally, I conclude that the scaffolding metaphor is fundamentally flawed and advance an alternative view that may more successfully promote correspondence between instructional activities and our emerging vision of the dynamics of teaching and learning.
Validity and Entailment in Modal and Propositional Dependence Logics

The computational properties of modal and propositional dependence logics have been extensively studied over the past few years, starting from a result by Sevenster showing NEXPTIME-completeness of the satisfiability problem for modal dependence logic. Thus far, however, the validity and entailment properties of these logics have remained mostly unaddressed. This paper provides a comprehensive classification of the complexity of validity and entailment in various modal and propositional dependence logics. The logics examined are obtained by extending the standard modal and propositional logics with notions of dependence, independence, and inclusion in the team semantics context. In particular, we address the question of the complexity of validity in modal dependence logic. By showing that it is NEXPTIME-complete we refute an earlier conjecture proposing a higher complexity for the problem.
Monitoring of Hypercoagulability by Thromboelastography in Bariatric Surgery

Background Obesity is known as a major risk factor for postoperative vein thrombosis. Thromboelastography (TEG) is used to monitor viscoelastic features of blood clots. The aim of this study was to determine hypercoagulable states in patients undergoing bariatric surgery and to assess dynamics of coagulation parameters in the perioperative setting using TEG. Material/Methods We included 60 consecutive patients undergoing bariatric surgery. TEG alterations were assessed at 4 time points: at baseline, after the surgery, and on postoperative day 1 (POD1) and 2 (POD2). Hypercoagulable state was defined when patients showed clot strength (G) of ≥11 dynes/cm2 or maximum amplitude (MA) ≥68 mm. Results Fourteen patients (23.3%) out of 60 showed hypercoagulability prior to surgery on TEG. Fibrinogen levels were significantly higher in the G ≥11 group compared to the G <11 group, at 4.2 and 3.8 g/l, respectively (p=0.02). Seventeen patients (28.3%) had MA ≥68 mm at baseline. Fibrinogen levels increased significantly from 3.90 at baseline to 4.16 g/l in POD2 (p<0.001). There was an increase in mean reaction time from baseline (6.74 s) to POD2 (7.43 s, p=0.022). We found a correlation between baseline fibrinogen levels and MA (R=0.431, p=0.001) or G (R=0.387, p=0.003). ROC curve analysis showed that fibrinogen levels can predict clot strength (G) ≥11 dynes/cm2 with AUC=0.680 (p=0.044). Conclusions A considerable proportion of patients referred to bariatric surgery show a trend towards hypercoagulability on TEG. This study shows the potential of hypercoagulation monitoring by TEG in the perioperative setting of bariatric surgery.
A bubble-powered micro-rotor: conception, manufacturing, assembly and characterization

A steady fluid flow, called microstreaming, can be generated in the vicinity of a micro-bubble excited by ultrasound. In this paper, we use this phenomenon to assemble and power a microfabricated rotor at rotation speeds as high as 625 rpm. The extractible power is estimated to be of the order of a few femtowatts. A first series of experiments with uncontrolled rotor shapes is presented, demonstrating the possibility of this novel actuation scheme. A second series of experiments with 65 µm rotors micromanufactured in SU-8 resin is then presented. Variables controlling the rotation speed and rotor stability are investigated, such as the bubble diameter, the acoustic excitation frequency and amplitude and the rotor geometry. Finally, an outlook is provided on developing this micro-rotor into a MEMS-based motor capable of delivering tunable, infinitesimal rotary power at the microscale.
Reproduction phase‐related variations in neuropeptide Y immunoreactivity in the olfactory system, forebrain, and pituitary of the female catfish, Clarias batrachus (Linn.)

The aim of this study was to determine whether neuropeptide Y (NPY) immunoreactivity in the cells and fibers in the forebrain and pituitary of Clarias batrachus is linked to the annual reproductive cycle. A steady rise in luteinizing hormone (LH) immunoreactivity was seen in the pituitary through preparatory (February–April) and prespawning (May–June) phases; it was greatly reduced during spawning (July–August; P < 0.001) and partially replenished during postspawning (September–November; P < 0.01) through resting (December–January) phases. Although NPY immunoreactivity in olfactory receptor neurons and olfactory nerve layer in olfactory bulb was gradually augmented during resting through prespawning phases (P < 0.001), attaining a peak in spawning phase (P < 0.001), a dramatic decline was encountered during postspawning phase (P < 0.001). A similar pattern was also observed in NPY‐containing fibers of the medial olfactory tract (MOT) and pituitary. However, a different pattern of NPY immunoreactivity was observed in the neurons of nucleus entopeduncularis (NE) and nucleus preopticus periventricularis (NPP). Whereas these neurons and fibers in the forebrain showed significant augmentation during the resting through prespawning phases (P < 0.001), the immunoreactivity dramatically declined during spawning (P < 0.001) and was partially replenished in the postspawning phase. Testosterone injection of juveniles significantly augmented (P < 0.001) NPY immunoreactivity in NE neurons. We suggest that NPY cells of NE and NPP, and related fiber systems, might be involved in processing of sex steroid‐borne information and regulation of the gonadotropin‐releasing hormone‐LH axis. J. Comp. Neurol. 504:450–469, 2007. © 2007 Wiley‐Liss, Inc.
TEMPERATURE-INDUCED SAP FLOW IN EXCISED STEMS OF ACER.

The flow of sap from openings in the stems of Acer and some other woody genera has for many years received considerable attention and study. In maple, the flow is induced by temperature changes and a review of the literature indicates that practically all of the experimental work has been conducted in the field. It seemed desirable therefore to investigate some aspects of the flow mechanism in the laboratory where temperatures could be controlled.
The Effects of Undergarment Composition Worn Beneath Hockey Protective Equipment on High-Intensity Intermittent Exercise

Abstract Noonan, B and Stachenfeld, N. The effects of undergarment composition worn beneath hockey protective equipment on high intensity intermittent exercise. J Strength Cond Res 26(9): 2309–2316, 2012—The purpose of this study was to examine the impact of undergarment composition worn beneath ice hockey protective equipment on thermal homeostasis and power output, during a cycle ergometer exercise protocol designed to simulate the energy expenditure of a hockey game. We hypothesized that the layers of protective equipment would negate the potential thermoregulatory benefits from synthetic “wicking” undergarments but that subjects may feel more comfortable because of the inherent low moisture retention of these fabrics. Eight men (age, 25.4 ± 1.3 year) performed a repeated sprint test before and after a simulated game under typical hockey conditions (12°C; 82% relative humidity). This test was completed twice while wearing full protective equipment and either synthetic (SYN) or cotton (COT) full-length undergarments. During the simulated game, skin temperatures (34.22 ± 0.20°C vs. 34.46 ± 0.16°C) and core temperatures (37.50 ± 0.13°C vs. 37.59 ± 0.14°C) were similar between SYN and COT, respectively. There were also no significant differences found in sweat loss as a percent of body mass, heart rate, plasma lactate, sprint power, or ratings of perceived exertion between SYN and COT, respectively. The SYN retained less water than COT (140 ± 30 vs. 310 ± 30 g; p < 0.05); however, clothing and protective equipment weight gains as a whole were unaffected by the fabric worn (470 ± 110 vs. 590 ± 80 g) for SYN and COT, respectively. There were minimal differences in thermal sensation and undergarment wetness ratings during the simulated game. Thermoregulation and performance was driven more by properties of the layered protective equipment with minimal effects from undergarment composition.
GEOMETRICAL EFFICIENCY OF PLANE-PARALLEL IONIZATION CHAMBERS IN PROTON SCANNING BEAM

For commissioning of a proton therapy unit depth dose distributions must be determined and introduced into the Treatment Planning System. In pencil beam scanning (PBS) technique, integral depth dose (IDD) acquisition should be performed with detector large enough to ensure entire beam laterally broadened by scattered and secondary contributions. The purpose of this article is to quantify, using measurements and Monte Carlo transport calculations, the ionization chamber's (IC) geometrical efficiency versus the chamber radius and proton beam energy. The geometrical efficiency of 0.99 was determined for energies up to 160 and 190 MeV for 4.08 and 6 cm radius IC. Much lower geometrical efficiency was obtained for the energy of 226.08 MeV and results in charge loss of 5.8 and 3.6%, respectively. Relative IDD differences between IC 4.08 and 6 cm in radius increase with proton energy and reach 2.4% at the mid-range depth for 226.08 MeV.
Shift work, Job Stress, and Late Fetal Loss: The National Birth Cohort in Denmark

Objective: The Danish National Birth Cohort (DNBC) was used to examine whether shift work or job stress correlate with late fetal loss. Methods: We identified 33,694 pregnancies of daytime workers and 8,075 pregnancies of shift workers in women recruited to the DNBC between 1998 and 2001. Pregnancy outcomes were obtained by linkages to the national registers. Hazard ratios of fetal loss were calculated by using Cox regressions with left truncation. Results: Fixed night work was associated with fetal loss (hazard ratio = 1.85, 95% confidence interval = 1.00–3.42). No high risk of fetal loss was seen for other types of shift work. Job stress, as measured in our study, was not associated with fetal loss. Conclusions: Our results suggest that fixed night work during pregnancy increases the risk of late fetal loss.
Low-frequency repetitive transcranial magnetic stimulation for patients with aphasia after stoke: A meta-analysis.

OBJECTIVE To perform a meta-analysis of studies investigating the effects of low-frequency repetitive transcranial magnetic stimulation on post-stroke aphasia. DATA SOURCES Studies were identified by performing a search of electronic databases (MEDLINE, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Knowledge) for articles published until June 2014. STUDY SELECTION Randomized controlled trials (RCTs) reporting treatments with low-frequency repetitive transcranial magnetic stimulation in patients with post-stroke aphasia were included. The outcomes included naming, repetition, comprehension, changes in brain excitability, and adverse events. DATA EXTRACTION Two independent reviewers extracted the data. Study quality was evaluated with the PEDro scale. DATA ANALYSIS Of the 879 articles identified, 4 RCTs were included in the final analysis. Data synthesis showed that low-frequency repetitive transcranial magnetic stimulation was beneficial for post-stroke patients in terms of naming (standard mean difference (SMD) 0.51; 95% confidence interval (95% CI) 0.16-0.86) and changes in brain excitability (7.6 ± 33.55; 95% CI -10.7-26.20). However, the changes in repetition (SMD 0.31; 95% CI -0.04-0.65) and comprehension (SMD 0.31; 95% CI -0.14-0.75) after stimulation were not significant. No adverse effects were reported. The included studies were of high methodological quality. CONCLUSION These findings indicate that low-frequency repetitive transcranial magnetic stimulation is an effective treatment for recovery of naming. In addition, this treatment favours reorganization of the left-hemispheric language networks.
Cost‐effectiveness of KRAS testing in metastatic colorectal cancer patients in the United States and Germany

The objective of this study was to determine the cost‐effectiveness of testing for KRAS mutations before administering EGFR inhibitors such as cetuximab and panitumumab for patients with advanced metastatic colorectal cancer (mCRC) in the United States and Germany. We developed a lifetime Markov model of costs and survival associated with treating mCRC patients to assess the impact of KRAS testing before administering EGFR inhibitor‐containing chemotherapy regimens. Overall, combination therapies involving cetuximab plus irinotecan/FOLFIRI had a better life expectancy (25.83 weeks) than cetuximab or panitumumab alone. Use of KRAS testing (assuming KRAS mutant patients receive only irinotecan) was equally effective and saved $12,428 per patient in the United States. When KRAS mutant patients received best supportive care, the life expectancy decreased slightly (24.26 weeks vs. 25.83 weeks) and the costs decreased by $13,501 in the United States and €9,560 in Germany. For patients treated with cetuximab alone, use of KRAS testing to identify mutations lowered costs by $8,040 per patient in the U.S. analysis and €3,856 per patient in the German analysis. For patients treated with panitumumab alone, use of KRAS testing to identify mutations lowered costs by $7,546 per patient in the U.S. analysis and €4,612 per patient in the German analysis. Model results were sensitive to the cost of chemotherapy regimens and the prevalence of KRAS mutations in the population. Under most scenarios, using KRAS testing to select patients for EGFR inhibitor therapy saved $7,500–$12,400 per patient in the United States and €3,900–€9,600 per patient in Germany with equivalent clinical outcomes.
Efficacy and Safety of Salmeterol/fluticasone Combination Therapy in Infants and Preschool Children with Asthma Insufficiently Controlled by Inhaled Corticosteroids

Abstract Background: Clinical evidences of inhaled salmeterol/fluticasone propionate combination (SFC) therapy are insufficient in early childhood asthma. Objectives: To examine the effects of SFC50, a combination product of salmeterol xinafoate (50 μg/day) and fluticasone propionate (100 μg/day), in infants and preschool children with asthma. Methods: The study was conducted at 31 sites in Japan. 35 patients (6 months to 5 years old) with asthma insufficiently controlled by inhaled corticosteroids (100 μg/day) were initiated to treat with SFC50 twice a day for 12 weeks with pressurized metered dose inhalers. The efficacy of SFC50 was assessed using nighttime sleep disorder score as the primary endpoint and the other efficacy measurements. The safety measurement included the incidences of adverse event (AE). Results: Mean patient age was 3.1 years, and 94.2% had mild-to-moderate persistent asthma (atopic type: 65.7%). Nighttime sleep disorder scores, assessed by a nighttime sleep diary, significantly decreased after treatment with SFC50 throughout the study period (p<0.01). SFC50 also significantly improved other efficacy outcomes including asthma symptom score, frequency of short-acting beta-agonist treatment, frequency of unscheduled visits to clinic, frequency of exacerbation due to virus infection, asthma control score and patient QOL score (p<0.01). AEs of cold, upper respiratory inflammation and asthmatic attack occurred in each of the 3 patients (8.6%); however, these were not regarded as treatment-related AEs. Conclusions: SFC50 improved nighttime sleep disorder score and other efficacy outcome measures with no safety concerns. The results suggest that SFC50 treatment is useful to control the mild-to-moderate asthma in infant and preschool-aged children.
Inorganic anions in goat and ovine milk from Calabria (Italy) by suppressed ion chromatography

Forty-seven samples of milk taken from goat and ovine farms in Calabria (southern Italy) between April and May 2010 were analysed. Analyses were carried out by ion chromatography (ICS 1000; Dionex). For method validation, RSDs (%) on retention times and on peak area were determined by considering a mixture of standard anions at the concentration level of 0.1–30 mg l−1 for chloride, bromide, nitrite, nitrate, sulfate and phosphate. The higher RSDs were 1.4% and 2.2% for retention times and 2.4% and 3.7% for areas for intra- and inter-day repeatability, respectively. Good linearity was observed in each concentration range, with linear correlation coefficients (R 2) better than 0.987. The LODs and LOQs were calculated experimentally as signal-to-noise ratios of 3 and 10, respectively. Analysis of the results obtained indicated that phosphates were the most abundant anion (1409–3050 mg l−1) followed by chloride (679–2568 mg l−1) and sulfates (25–341 mg l−1). Nitrates were found to be lower at 146 mg l−1 (the maximum value observed). The values of anions found in this work are in agreement with those reported in the literature for cow's milk. There are no significant differences between ovine and goat's milk samples. The method used for this analysis of anions combines rapidity with high precision, accuracy and sensitivity; therefore, it is suitable for routine analysis. Moreover, one of the most obvious advantages of this technique is that multiple elements can be determined in one sample with no serial dilutions and the complete analysis can be performed by using only one instrument.
Effect of antiarrhythmic drugs on the premature action potential duration in canine cardiac Purkinje fibers.

We studied the effect of six class I antiarrhythmic drugs, i.e., quinidine (5 micrograms/ml), disopyramide (10 micrograms/ml), procainamide (30 micrograms/ml), flecainide (4 micrograms/ml), lidocaine (4 micrograms/ml) and mexiletine (4 micrograms/ml), on the durations of the basic action potential (APDb) at a cycle length of 500 ms and on the premature APD (APDt) elicited at progressively increasing diastolic intervals (DI) in canine Purkinje fibers. The difference between APDt elicited at diastolic intervals of 100 msec and the earliest APDt elicited at the onset of effective refractory period was defined as the range of APDt. In control this range was 98 +/- 1.8 ms (n = 59). Disopyramide and procainamide did not change the range significantly but the other four drugs decreased it significantly (P less than .01) as follows: quinidine by 50.2%, lidocaine by 60.2%, mexiletine by 61.6% and flecainide by 61.4%. The following four factors contributed to this decrease in range of APDt: shorter duration of APDb, increased effective refractory period/APD ratio, slower kinetics of APD restitution, and shift of normalized restitution curve toward longer APDt values. The magnitude of the contribution made by each of the above factors varied with different drugs. The greatest contributing factor for quinidine was an increased effective refractory period/APD ratio, for lidocaine a slower restitution and for flecainide and mexiletine the shift of the restitution curve. We concluded that antiarrhythmic drugs belonging to the same class have different effects on the range of premature APD and that these effects cannot be predicted from the effect of the drug on APDb alone.