Miracle-dz/UniFAR-FTUs huggingface dataset:
The Failure of Success Factors: Lessons from Success and Failure Cases of Enterprise Architecture Implementation [Best Paper Nominee]

Many Enterprise Architecture programmes fail to meet expectations. While much has been written about the factors influencing the success of EA programmes, there are few empirical investigations of the role of critical success factors (CSFs) in the success of EA programmes. This study condensed the very broad literature on CSFs for EA identifying six key CSFs that share a broad consensus in the literature. A qualitative case study was conducted to test the hypothesis that the six key CSFs would distinguish between the successful and the unsuccessful programmes. Analysis of the case study data reveals that three key CSFs associated with the use of EA tools did not distinguish between successful and unsuccessful cases while three key CSFs related to the process of EA programme implementation did so. The study concludes that success in EA programmes comes more from how architecture is practiced than what is practiced. The findings have important implications for EA suggesting that the methodological skills of architects need to be supplemented with an understanding of practice.
Comparison between Intestinal Behçet's Disease and Crohn's Disease in Characteristics of Symptom, Endoscopy, and Radiology

Aim To evaluate different parameters in differentiating intestinal BD from CD. Methods The medical records of inpatients with intestinal BD and CD were retrospectively reviewed. The univariate value of different parameters was analyzed, respectively. A differentiation model was established by pooling all valuable parameters together. Diagnostic efficacy was evaluated, and a receiver operating curve (ROC) was plotted. Results Forty-two BD patients and ninety-seven CD patients were reviewed. Demographic and clinical parameters that showed significant value included diarrhea, fever, perianal disease, oral ulcers, genital ulcers, skin lesions, and musculoskeletal lesions. Endoscopic parameters reaching clinical significance included multiple-site lesions, lesions confined to the ileocecal region, longitudinal ulcers, round or oval ulcers, punch-out ulcers, ulcers with discrete margin, ulcer size > 2 cm, stricture of bowel, and anorectal involvement. Radiologic parameters aiding the differentiation included involvement segments ≤ 3, asymmetrical pattern of involvement, intraluminal pseudopolyp formation, target sign, stricture with proximal dilation, comb sign, and fistula. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of the differentiation model were 90.5%, 93.8%, 92.8%, 86.4%, and 95.8%, respectively. The cutoff value was 0.5 while the area under the ROC curve was 0.981. Conclusion The differentiation model that integrated the various parameters together may yield a high diagnostic efficacy in the differential diagnosis between intestinal BD and CD.
Discriminative stimulus effects of 8-hydroxy-2-(di-n-propylamino)tetralin in pigeons and rats: species similarities and differences.

In this study we examined the effects of 5-HT1A ligands in rats trained to discriminate 0.16 mg/kg i.p. 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) from saline in a two-lever, fixed ratio (FR)10 schedule of food reinforcement, and in pigeons trained to discriminate 0.31 mg/kg i.m. 8-OH-DPAT from saline in a two-key, FR30 schedule of food reinforcement. In both species, 8-OH-DPAT and a variety of structurally unrelated 5-HT1A ligands occasioned dose-related, relatively high levels of drug-appropriate selection (i.e. > or = 67%). A significant positive correlation was found between estimated ED50 values in both species (r = 0.84, P < .001). Further, 5-HT1A antagonists, NAN-190, penbutolol, (-)-pindolol, tertatolol and WAY-100635, produced dose-related decreases in 8-OH-DPAT-appropriate selection, and their potencies for antagonism in rats and pigeons were highly correlated (r = 0.96, P < .01). The potency of WAY 100635 in rats and pigeons was quantified by Schild analysis (apparent in vivo pA2 values: 7.8 vs. 8.3, rat vs. pigeon respectively). Although most 5-HT1A agonists produced similar 8-OH-DPAT-like discriminative stimulus effects in both species, two compounds, lisuride and eltoprazine, occasioned high levels of drug-appropriate selection in pigeons, but not in rats. In contrast, idazoxan, yohimbine, LEK 8804 and BMY 7378 produced greater effects in rats. Among this latter group of compounds, only BMY 7378 blocked the discriminative stimulus effects of 8-OH-DPAT in pigeons, which suggested that intermediate levels of drug-appropriate selection observed with the remaining compounds are not necessarily the result of low intrinsic activity. Overall, these results demonstrate similarities in the discriminative stimulus effects of 8-OH-DPAT in rats and pigeons despite different training conditions (e.g., training dose and route of administration). Even so, the finding that some 5-HT1A ligands did not produce similar effects in rats and pigeons illustrates the need to examine possible 8-OH-DPAT-like discriminative stimulus effects of compounds in both species.
Low pay but still we stay: Retention in early childhood education and care

A professional, skilled and engaged early childhood workforce is critical to economic and social productivity and positive life trajectories for children. Yet high staff turnover, skill loss and unmet standards of staff qualification pervade the sector, limiting optimal outcomes. For many early childhood educators, alternatives of better paid and less challenging sources of employment are available in other employment sectors, a fact that explains turnover rates as high as 30%. However, this study reverses the emphasis on why early childhood educators leave the sector and asks instead ‘Why do so many stay? '. This question is a significant one when it is considered that the remuneration of educators in early childhood barely meets minimum wage thresholds, and that they face challenging working conditions and few opportunities for career progression. The findings of the study contribute to an understanding of retention in early childhood education and care occupations specifically, and in feminised, low-paid occupational groups more broadly. The study also informs policy and strategy responses to low retention in the early childhood sector in Australia and internationally.
Alpha‐glucosidase deficiency and basilar artery aneurysm: Report of a sibship

Glycogen deposition in vascular smooth muscle has been demonstrated previously in alpha‐glucosidase deficiency but has not been clinically significant. Three sons of healthy, nonconsanguineous parents developed progressive proximal muscular weakness secondary to alpha‐glucosidase deficiency. Each patient developed a fusiform basilar artery aneurysm, which was complicated by fatal rupture in two patients and a cerebellar infarction in the third. Postmortem examination demonstrated severe vacuolation of skeletal muscle, liver, and vascular smooth muscle with accumulation of periodic acid‐Schiff–positive, diastase‐sensitive material. In the surviving brother, similar glycogen deposition was demonstrated in the smooth muscle of the superficial temporal artery. Basilar artery aneurysm formation in this sibship may be a consequence of alpha‐glucosidase deficiency.
Cyclooxygenase‐2 inhibition partially protects against 60% O2‐mediated lung injury in neonatal rats

Use of the anti‐inflammatory agent dexamethasone in premature infants with bronchopulmonary dysplasia has been curtailed, and no alternative anti‐inflammatory agents are approved for this use. Our objective was to use a neonatal rat model of bronchopulmonary dysplasia to determine if an highly selective cyclooxygenase‐2 inhibitor, 5,5‐dimethyl‐3‐(3‐fluorophenyl)4‐(4‐methylsulfonyl)phenyl‐2(5H)‐furanone (DFU; 10 µg/g body weight), could prevent inflammatory cell influx and protect against lung injury.
Current challenges in clinical target volume definition: Tumour margins and microscopic extensions

Abstract Determination of optimal clinical target volume (CTV) margins around gross tumour volume (GTV) for modern radiotherapy techniques, requiring more precise target definitions, is controversial and complex. Tumour localisation has been greatly improved using molecular imaging integrated with conventional imaging techniques. However, the exact incidence and extent of microscopic disease, to be encompassed by CTV, cannot be visualised by any techniques developed to date and remain uncertain. As a result, the CTV is generally determined by clinicians based on their experience and patients’ histopathological data. In this article we review histopathological studies addressing the extent of subclinical disease and its possible correlation with tumour characteristics in various tumour sites. The data have been tabulated to facilitate a comparison between proposed margins by different investigations and with current margins generally accepted for each tumour site. It is concluded that there is a need for further studies to reach a consensus on the optimal CTV pertaining to each tumour site.
Tracking of serum cholesterol levels in a multiracial sample of preschool children.

The relation of an initial measurement of serum total cholesterol to subsequent levels over a (mean) 13-month interval was examined in a multiracial (white, Hispanic, American Indian, and black) sample of 1680 one- to four-year-olds. Although the relation of the initial level to the final measurement (r = .54) did not vary by race, sex, relative weight, or changes in relative weight, the association increased with age at the time of the initial measurement (eg, r = .64 among 4-year-olds). Based on the initial and final total cholesterol determinations, the within-person standard deviation was 21 mg/dL and the coefficient of variation was 13%. Although the final total cholesterol level was within 5 mg/dL of the initial level for 18% of the children, the two determinations differed by greater than or equal to 25 mg/dL for about 35% of the children and by greater than or equal to 50 mg/dL for about 8%. Of the 149 children who had an initial cholesterol level greater than or equal to 200 mg/dL, 34% (about five times the expected number) had a follow-up level that was similarly elevated whereas 25% had a subsequent measurement below 170 mg/dL. The results indicate that although an initial cholesterol level in early life is moderately predictive of subsequent levels, it may be difficult to interpret a single total cholesterol determination because of substantial within-person variability.
Knowledge, innovation, internationalisation and performance: insights from the Portuguese footwear industry

This paper seeks to promote a better understanding of the relationships between, and possible effects of strategic knowledge management (SKM), innovation, internationalisation and performance in the Portuguese footwear industry. The rationale for this research is based on the understanding that innovation has played a major role in the recent good performance and internationalisation of this industry - trends that have developed despite Portugal's economic recession. The study used a quali-quantitative methodology, gathering data through semi-structured interviews with chief executive officers of footwear firms and academics specialising in innovation. In addition, a questionnaire was distributed that concentrated on the largest geographical cluster of Portugal's footwear industry. We found support for our initial expectation that SKM is mostly absent from these firms' formal practices: codification is seldom considered, and personalisation tends to be informal. Nevertheless, SKM was found to contribute to innovation, and more innovative firms are more extensively and deeply internationalised.
Efficacy of tiotropium and indacaterol monotherapy and their combination on dynamic lung hyperinflation in COPD: a random open-label crossover study

Background and objective The difference in efficacy of long-acting muscarinic antagonists (LAMAs) and long-acting β2-agonists (LABAs) for dynamic lung hyperinflation (DLH) in COPD is unclear. The purpose of this study was to elucidate the difference in efficacy of LAMA and LABA alone and the combination thereof for DLH. Subjects and methods Thirty stable patients were enrolled and randomly divided into two groups following baseline measurements. One group was treated with 5 μg tiotropium (Respimat inhaler) for 4 weeks following a 4-week treatment with 150 μg indacaterol, while the other group was treated with indacaterol for 4 weeks following a 4-week treatment with tiotropium. For both groups, these treatments were followed by a combination of the two drugs for 4 weeks. Pulmonary function tests, including DLH evaluated by metronome-paced incremental hyperventilation and exercise tolerance evaluated by the shuttle-walk test, were performed at the end of each treatment period. Results In total, 23 patients completed this study. Both tiotropium and indacaterol alone significantly increased forced expiratory volume in 1 second, exercise tolerance, and improved health status. Tiotropium significantly improved DLH, but indacaterol did not. The combination therapy resulted in further improvements in lung function and exercise tolerance, but not in DLH. Conclusion The efficacy of tiotropium in inhibiting DLH following metronome-paced incremental hyperventilation may be superior to that of 150 μg indacaterol, although the effects on airflow obstruction were the same, and the combination therapy showed further improvement in airflow obstruction, but not in DLH.
Shared Advocacy: A Multiple-Case Examination of Practices Supporting Postsecondary Students with Learning and Attention Differences

This multiple-case study examined the practices of academic support providers who offered supplemental services for students with learning or attention differences at postsecondary institutions. Students with learning or attention differences transitioning to postsecondary institutions may need assistance developing self-advocacy through practice. The study employed self-determination theory and positive psychology (Deci & Ryan, 2002; Seligman, 2011), asking the central research question, “How do academic support providers at postsecondary institutions offer shared-advocacy, promoting intrinsic motivation through accommodative intervention strategies for students with learning disabilities and/or ADHD? ” Previously unheard perspectives of academic support providers at five postsecondary institutions presented these insights. Analysis occurred through description, classification, and interpretation of the data collected from interviews, focus groups and supporting documentation. Triangulation of inputs formed a picture of each institution, embedded in the interactions between support providers, the environment, and those they collaborated with to provide support for students with learning and attention differences (Yin, 2014). Cross-case analysis from each of five postsecondary institutions yielded a synthesized understanding of practitioner responses that facilitate selfdetermination. Through analysis, common themes emerged including connectivity, accessibility, eligibility, responsivity, and extended support. Findings described the process for establishing new services, types of accommodations made available, means for disseminating accessibility of new options, effective practices of academic support providers and circumstances that worked in their favor when initiating new support systems.
THE ROLE OF RELIGIOUS INSTITUTIONS FOR CONFLICT MANAGEMENT: EXPERIENCE OF NATIONAL COUNCIL OF CHURCHES OF KENYA

Most of the time, religion viewed as a motive for conflict and has emerged as a key component in many current and past conflicts. However, religion does not always drive violence; it is also an integral factor in the peace building and reconciliation process. So, this paper assessed the peace building contribution role of the National Council of Churches of Kenya (NCCK), following the post-2007 election violence in Kenya. The National Council of Churches of Kenya took instant humanitarian and peace building roles during the 2007 election violence. There was the provision of psychosocial support to address issues of trauma occasioned by loss of lives and infliction of emotional and physical harm. In addition, it also conducted the provision of food and non food items. Moreover, capacity building workshops for church leaders were held to build their capacity in mediation and peace building skills. Furthermore, In addition, ecumenical joint services were held incorporating the Christians, the Muslims and the Hindus. Finally, the Council was involved in influencing the passage of pieces of legislation such as the Truth, Justice and Reconciliation Act , National Cohesion and Integration Act, The Constitutional Review Act of 2008, and the Witness Protection Act in the Kenyan Parliament. In general, The paper deals with issues such as the general background of the role of religion in Africa as both source of conflict and peace building; the cause and impacts of 2007 election violence in Kenya; the background and the role of religious institution (National Council of Churches of Kenya) in the post 2007 election violence in Kenya; and my conclusion is included at last. In short, I tried to assess to what extent religious institutions should play a role in managing conflict based on religious connections in Africa by taking the case study of Kenya.
Detection, purification, and partial characterization of plantaricin C, a bacteriocin produced by a Lactobacillus plantarum strain of dairy origin

A bacteriocin produced by Lactobacillus plantarum LL441 was selected from the inhibitory products of 75 mesophilic lactobacilli because of its potency and broad spectrum. It is a peptide of 3.5 kDa whose amino-terminal sequence is NH2-K-K-T-K-K-N-X-S-G-D-I-. It is bactericidal and, in some cases, bacteriolytic. The peptide, called plantaricin C, retained its activity after boiling, storage, and treatment at different pHs.
Comparative in vitro percutaneous absorption of nonylphenol and nonylphenol ethoxylates (NPE-4 and NPE-9) through human, porcine and rat skin

The purpose of this study was to assess the percutaneous absorption of nonylphenol (NP) and the nonylphenol ethoxylates, NPE-4 and NPE-9, in human, porcine and rat skin. In vitro studies with the NPEs were conducted for 8 h in flowthrough diffusion cells using topical solutions of 0.1, 1.0 and 10% in PEG-400 or 1% in water (NPE-9 only). NP absorption was assessed as a 1% solution in PEG-400. All compounds were 14C ring-labeled and radioactivity in perfusate was monitored over time. Skin deposition was measured at the termination of the experiment. Absorption into perfusate and total penetration (compound absorbed plus compound sequestered in skin) were calculated. Absorption of NPE-4, NPE-9 and NP was similar across all species at less than 1% of the applied dose over 8 h. Penetration was generally below 5% of applied dose, the majority located in the stratum corneum. In all species and for both NPEs, the fraction of dose absorbed was highest for the lowest applied dose. Absorptions expressed as actual mass absorbed over 8 h were similar (approximately 0.3 μg/cm2) across all concentrations. Penetration, but not absorption, was greater from a water vehicle compared to a PEG-400 vehicle, particularly in rat skin. These studies suggest that NP, NPE-4 and NPE-9 were minimally absorbed across skin from all three species. Fractional absorption was concentration-dependent, making the actual absorbed flux constant across all doses.
Optimization-Based Separations for Neural Networks

Depth separation results propose a possible theoretical explanation for the benefits of deep neural networks over shallower architectures, establishing that the former possess superior approximation capabilities. However, there are no known results in which the deeper architecture leverages this advantage into a provable optimization guarantee. We prove that when the data are generated by a distribution with radial symmetry which satisfies some mild assumptions, gradient descent can efficiently learn ball indicator functions using a depth 2 neural network with two layers of sigmoidal activations, and where the hidden layer is held fixed throughout training. By building on and refining existing techniques for approximation lower bounds of neural networks with a single layer of non-linearities, we show that there are $d$-dimensional radial distributions on the data such that ball indicators cannot be learned efficiently by any algorithm to accuracy better than $\Omega(d^{-4})$, nor by a standard gradient descent implementation to accuracy better than a constant. These results establish what is to the best of our knowledge, the first optimization-based separations where the approximation benefits of the stronger architecture provably manifest in practice. Our proof technique introduces new tools and ideas that may be of independent interest in the theoretical study of both the approximation and optimization of neural networks.
Ondansetron hydrochloride: a competitive serotonin 5-HT3 receptor blocker.

The methyl substituted imidazole ring in the title compound, 2-methyl-1-(9-methyl-4-oxo-2,3,4,9-tetrahydro-1H-carbazol-3-yl) imidazol-3-ium chloride dihydrate, C18H20N3O+. Cl-. 2H2O, is approximately perpendicular to the carbazole plane [dihedral angle 87.0(1) degrees]. The water molecules are involved in an elaborate network of hydrogen bonds that reinforce the stability of the dihydrate and the cohesion of the structure.
Longitudinal assessment of medical student attitudes toward older people

Abstract Delivering adequate care to older people requires an increasing number of physicians competent in the treatment of this expanding subpopulation. Attitudes toward older adults are important as predictors of the quality of care of older people and of medical trainee likelihood to enter the geriatrics field. This study assessed the attitudes of 404 US medical students (MS) from the start of medical school to graduation using the University of California, Los Angeles (UCLA) Geriatrics Attitude Scale. It is the first study to utilize a longitudinal design to assess attitudes among students in a medical school with a longitudinal geriatrics clinical experience in the first two years and a required geriatrics clerkship in the third year. Participants’ attitude scores toward older people were found to significantly decrease from 3.9 during the first two years to 3.7 during the final two. Significant differences existed between MS1 and MS3, MS1 and MS4, MS2 and MS3, and MS2 and MS4. Women and older students held significantly more positive attitudes than men and younger students. These results show that planned clinical exposures to older adults may not be sufficient to halt the decline in attitudes in medical school. A comprehensive empathy-building intervention embedded in the curriculum may better prevent this decline.