Miracle-dz/UniFAR-FTUs huggingface dataset:
Outpatient treatment of patients with deep-vein thrombosis or pulmonary embolism

There have been a large number of randomized trials comparing standard unfractionated intravenous heparin with low–molecular-weight heparin for the treatment of deep-vein thrombosis, but only two of these have looked at outpatient therapy. There have been only two randomized trials including patients with symptomatic pulmonary embolism, and neither of these provided outpatient therapy. Postmortem and clinical studies have shown a strong association between pulmonary embolism and the presence of venous thrombosis in the lower limbs. Based on similar rates of venous thromboembolic recurrence and death, these studies suggest that initial treatment should be the same for deep-vein thrombosis and pulmonary embolism. The feasibility of providing outpatient care to many patients seeking treatment for deep-vein thrombosis or acute pulmonary embolism at certain tertiary care hospitals has become evident, but the data suggest that the proportion of eligible patients is institution dependent and may vary from 18% to 91%. In the author's institution, approximately 50% of patients with pulmonary embolism could be treated as outpatients, but there have been no other reports on outpatient therapy for patients with pulmonary embolism. If patients with pulmonary embolism meet criteria demonstrated to result in a higher risk of death, it is, of course, reasonable to not treat such patients on an outpatient basis. Low–molecular-weight heparin followed by oral anticoagulant therapy provides adequate therapy in most patients with deep-vein thrombosis or pulmonary embolism, and many patients can be treated as outpatients.
Ultra low power fault tolerant neural inspired CMOS logic

We present a new defect/fault tolerant ultra low power CMOS circuit exploiting low level redundancy. We show that wiring and transistors may be damaged while the functionality is still kept. We also demonstrate a new full adder based on the basic building block, capable of sub fJ power-delay-product for supply voltages below 100 mV, in a 120 nm process. The power-delay-product is reduced by about 50 % compared to the best previously published FA based on a 6 transistor reconfigurable subthreshold NOR-3, MAJ-3, NAND-3 circuit. Transistors are exploited as four terminal devices operating in subthreshold and DC characteristics for a threshold element is demonstrated by chip measurements.
Shading effects in back-junction back-contacted silicon solar cells

One of the most often mentioned advantages of back-junction back-contacted silicon solar cells is that this cell structure has no shading losses, because metallization fingers and busbars are both located on the rear side of the solar cell. However, this is only true if only optical shading losses are regarded. In this work electrical shading losses due to recombination in the region of base busbar and fingers are analyzed using two-dimensional numerical device and network simulations. The base doping dependence of these effects is investigated as well as the influence of the rear side passivation. The results of the simulations are compared with EQE maps of back-junction solar cells. The influence of the busbars is quantified and the influence on the overall cell performance is discussed.
Treatment of hodgkin's disease and other malignant lymphomas

Considerable progress has been made in the treatment of Hodgkin's disease and the other lymphomas during the past 15 years. The present paper summarizes, in part, studies which our department has conducted or in which we have participated during this period. Studies of chlorambucil, prednisone, mitorgen mustard, vinblastine, cytoxan, and vincristine used as single agents have shown the efficacy of these drugs in the treatment of particular lymphomas. Our patients with late stage Hodgkin's disease have been treated in protocols of the Acute Leukemia Group B in which various types of combination chemotherapy, with or without maintenance therapy, have been and are being explored. In our studies, combination chemotherapy has shown no better results than single agent induction followed by oral maintenance therapy with chlorambucil or cytoxan in treating lymphosarcoma. Treatment of reticulum cell sarcoma remains discouraging.
Effects of choice making on the serious problem behaviors of students with severe handicaps.

This study assessed the impact of choice making on the serious problem behaviors of 3 students with severe autism and/or mental retardation. In the context of within-subject reversal designs, the results showed consistently reduced levels of problem behaviors (e.g., aggression) when the students were given opportunities to make choices among instructional tasks and reinforcers. Additional data showed no systematic differences in the rate of correct responding between the two conditions. The results are discussed in relation to the continuing search for effective, nonintrusive solutions to the occurrence of serious problem behavior.
mutations origin an update of gaucher mutations distribution in the ashkenazi Jewish Population : Prevalence and country of origin of the mutation r 496 H

Background: Gaucher disease is the most prevalent inherited disorder among Ashkenazi Jews (carrier frequency of about 6%) and six mutations account for about 96% of their mutant alleles. Two mutations, N370S and R496H, have been reported only in mildly affected or asymptomatic patients. Due to the rarity of R496H, it was recommended that it be excluded from screening programs. objectives: To verify the frequency and trace the origin of Gaucher mutations in screened individuals whose Ashkenazi ethnicity was confirmed by the birthplace of their grandparents. methods: We conducted a retrospective analysis of the screened results for the period 2006–2011. Mutations were identified by restriction analysis, Tag-ItTM detection system, Pronto® diagnostic kit and Nanogen technology (NanoChip® 400). results: The heterozygote frequency of eight mutations was estimated in a cohort of 16,910 alleles. Two mutations, N370S and R496H, were the most frequent in our population. However, while the occurrence of N370S carriers was similar to other reports (1:19.4), that of R496H carriers was considerably elevated (1:207). Examination of the screened individuals’ ethnicity showed a significant difference in the distribution pattern of the country of origin between the carriers of these two mutations. conclusions: The origin pattern differences between the two groups of heterozygotes might reflect a separate geographic region of introduction for various mutations. As a result, secondary subgroups could be formed within the Ashkenazi population. This might clarify the dissimilarities in the occurrence of R496H mutation reported by various centers.
Re-Examining the Factor Structure of the California Critical Thinking Disposition Inventory

This study re-examined the factor structure of the California Critical Thinking Disposition Inventory developed by Facione and colleagues. Analysis showed that the four factors had some cross-validity with four factors in Walsh and Hardy's 1997 study. The results suggest the possibility of developing a more efficient short version of the inventory and calls for further improvement.
A Multilevel Analysis of Gatekeeper Characteristics and Consistent Condom Use Among Establishment-Based Female Sex Workers in Guangxi, China

Background: Multilevel analytical techniques are being applied in condom use research to ensure the validity of investigation on environmental/structural influences and clustered data from venue-based sampling. The literature contains reports of consistent associations between perceived gatekeeper support and condom use among entertainments establishment-based female sex workers (FSWs) in Guangxi, China. However, the clustering inherent in the data (FSWs being clustered within establishment) has not been accounted in most of the analyses. We used multilevel analyses to examine perceived features of gatekeepers and individual correlates of consistent condom use among FSWs and to validate the findings in the existing literature. Methods: We analyzed cross-sectional data from 318 FSWs from 29 entertainment establishments in Guangxi, China in 2004, with a minimum of 5 FSWs per establishment. The Hierarchical Linear Models program with Laplace estimation was used to estimate the parameters in models containing random effects and binary outcomes. Results: About 11.6% of women reported consistent condom use with clients. The intraclass correlation coefficient indicated 18.5% of the variance in condom use could be attributed to their similarity between FSWs within the same establishments. Women's perceived gatekeeper support and education remained positively associated with condom use (P < 0.05), after controlling for other individual characteristics and clustering. Conclusions: After adjusting for data clustering, perceived gatekeeper support remains associated with consistent condom use with clients among FSWs in China. The results imply that combined interventions to intervene both gatekeepers and individual FSW may effectively promote consistent condom use.
Tissue Activity and Cellular Localization of Human Semicarbazide-sensitive Amine Oxidase

SUMMARY Semicarbazide-sensitive amine oxidase (SSAO), widely distributed in highly vascularized mammalian tissues, metabolizes endogenous and xenobiotic aromatic and aliphatic monoamines. To assess whether its physiological role in humans is restricted to oxidation, we used an immunohistochemical approach to examine the cellular localization of SSAO in human peripheral tissues (adrenal gland, duodenum, heart, kidney, lung, liver, pancreas, spleen, thyroid gland, and blood vessels) and also analyzed its subcellular localization. The results are in agreement with the specific activities also determined in the same samples and are discussed with reference to the tissue distribution of monoamine oxidase A and B. Together with the oxidative deamination of monoamines, SSAO cellular localization indicates that, in most human peripheral tissues, it might participate in the regulation of physiological processes via H2O2 generation. (J Histochem Cytochem 49:209–217, 2001)
Data sets matter, but so do evolution and ecology

In a recent paper, Peterson & Nakazawa (2008) (hereafter PN) contest key findings in our study (Fitzpatrick et al ., 2007) that suggest that Solenopsis invicta (hereafter the fire ant) underwent a niche shift upon its invasion of North America. Using niche-based models, we proposed that the fire ant established in environments similar to those found in its native range but subsequently spread into environments unlike those found within its native range – a pattern strikingly similar to that suggested by Broennimann et al . (2007) for spotted knapweed ( Centaurea maculosa ). PN counter that our findings are simply an artefact of the environmental variables we used to model the fire ant’s distributions and suggest instead that selection of alternative variables can produce a more correct prediction of the fire ant’s invasion. PN conclude that the biological explanations offered in Fitzpatrick et al . (2007) for the non-predictivity between the fire ant’s native and invaded distributions, namely enemy release, genetic founder effects and hybridization, are not necessary. Here we respond to PN’s criticisms. We disagree with the contentions outlined in PN on the grounds that the authors (1) subjectively consider what represents a ‘correct’ prediction of the fire ant’s niche, (2) do not discuss the potential for niches to be conserved along some environmental axes but not others and, most significantly, (3) do not adequately represent our original analyses in Fitzpatrick et al . (2007) by not testing the ability of the fire ant’s invaded distribution to predict its native range using their alternative data sets. We demonstrate, using the procedures outlined in Fitzpatrick et al . (2007) and the set of environmental variables in PN that represents a subset of the variables used in Fitzpatrick et al . (2007), that the results from our original study stand. Issue 1: subjective consideration of what constitutes a ‘correct’ prediction
The Effect of Saliva on the Formation of KOH-Soluble Fluoride after Topical Application of Amine Fluoride Solutions of Varying Fluoride Concentration and pH

The effect of saliva on the amount of KOH-soluble fluoride formed on a sound enamelsurface after application of amine fluoride solution of varying fluoride concentrations (1, 0.5 and 0.25% F) and pH (5.3, 4.5 and 4.0) was examined in an in vitro study. The saliva pretreatment increased the amount of KOH-soluble fluoride at the highest pH value. For any given fluoride concentration, the presence of saliva did not influence the amount of KOH-soluble fluoride. These data suggest that saliva could enhance the amount of KOH-soluble fluoride if the topical fluoride preparations are not highly acid.
Circularly polarized reconfigurable patch antenna using Y-branched feed circuit

This paper is devoted to a circularly polarized patch antenna with the Y-branch feeding structure for switching circular polarization (CP) between left-hand CP (LHCP) and right-hand CP (RHCP). In this structure, the feed circuit is installed behind the ground plane because the electromagnetic distribution on the feeding line has no effect on the radiation pattern. In addition, the slot coupled structure is adopted to avoid a complicated manufacturing process like via-hole structures resulting in ease of fabrication of multi-layered structure. This provides an interest for us in the effect of the slot structure on cross-polarization discrimination (XPD) because we need two adjacent slots in the present structure.
Use of Ligasure Sealing Versus Conventional Suture - Ligation in Total Thyroidectomy

Introduction: Effective vessel haemostasis can be achieved by suture knot tying technique or newer techniques of vessel haemostasis like ligasure as an alternative bipolar surgical diathermy system. Various diathermy techniques have been proposed to reduce intraoperative blood loss in surgery and the new electrothermal bipolar tissue sealing system (Ligasure) has been applied in various specialties of surgery. The objective of this randomized study was to compare the outcome of ligasure versus conventional clamping and tie in total thyroidectomy for benign thyroid diseases. Patients and Methods: A total of 200 patients diagnosed to have bilateral BMNG were subjected to primary total thyroidectomy and divided into two main groups Ligasure (L) and Suture-Ligation (SL). For detection of laryngeal nerves status, vocal cords were checked immediately postoperatively by laryngoscope and at the day 10 of postoperative period to assess the status of both laryngeal nerves. The function of the parathyroids was checked by detecting the serum calcium concentration and parathyroid hormone level. The following parameters were measured to compare the effect of ligasure versus conventional suture-ligation technique in decreasing the operative blood loss, operative time, securing laryngeal nerves and parathyroids, postoperative drainage and postoperative wound infection. Results: There was no statistical difference between the two groups regarding age, sex and body mass index and also there was no operative mortality. As regard the operative time, in ligasure group it was 115.54 ±15.35 minutes while in suture-ligation group was 127.1 ±7.95 minutes and intraoperative blood loss in group A was 62.06 ± 7.34 and in group B was 75.84± 9.21. Temporary RLN injury was detected in 3 patients (3%) in group A and in 5 patients in group B (5%). No permanent hypoparathyroidism was seen in group A patients but in one patient (1%) of group B, transient hypoparathyroidism occurred in 2 patients (2%) of both groups. The amount of fluid drained in group A was 54.16 ±9.21 and 66.28 ±8.99 in group B. Conclusion: The use of the Ligasure sealing system in total thyroidectomy is proved safe and effective in reducing the operative time, intraoperative blood loss together with reduction in postoperative fluid drainage. Owing to the ability to reduce energy spread profile, use of Ligasure sealing system is accompanied with better outcome regarding the function of laryngeal nerves and parathyroids.
Cooperativity in ionic liquids.

Cooperativity in ionic liquids is investigated by means of static quantum chemical calculations. Larger clusters of the dimethylimidazolium cation paired with a chloride anion are calculated within density functional theory combined with gradient corrected functionals. Tests of the monomer unit show that density functional theory performs reasonably well. Linear chain and ring aggregates have been considered and geometries are found to be comparable with liquid phase structures. Cooperative effects occur when the total energy of the oligomer differs from a simple sum of monomer energies. Cooperative effects have been found in the structural motifs examined. A systematic study of linear chains of increasing length (up to nine monomer units) has shown that cooperativity plays a more important role than expected and is stronger than in water. The Cl.H distance of the chloride to the most acidic proton increases with an increasing number of monomer units. The average bond distance approaches 218.9 pm asymptotically. The dipole moment grows almost linearly and the dipole moment per monomer unit reaches the asymptotic value of 16.3 D. The charge on the chloride atoms decreases with an increasing chain length. In order to detect local hydrogen bonding in the clusters a new parametrization of the shared-electron number method is introduced. We find decreasing hydrogen bond energies with an increasing cluster size for both the first hydrogen bond to the most acidic proton and the average hydrogen bond.
Does Reinsurance Need Reinsurers?

The reinsurance market is the secondary market for insurance risks. It has a very specific organization. Direct insurers rarely trade risks with each other. Rather, they cede part of their primary risks to specialized professional reinsurers who have no primary business. This article offers a model of equilibrium in reinsurance and capital markets in which professional reinsurers arise endogenously. Their role is to monitor primary insurers credibly, so that insurers can raise capital more easily. In equilibrium, the financial structure of primary insurers consists of a mix of reinsurance and outside capital. The comparative statics yield empirical predictions which are broadly in line with a number of stylized facts from the reinsurance market.
Extracting phonon thermal conductance across atomic junctions: Nonequilibrium Green’s function approach compared to semiclassical methods

The thermal conductance of nanoscale phonon modes is typically calculated using the Boltzmann transport equation. A particular implementation of this method is the acoustic mismatch model (AMM) that compares impedance ratios at a mathematically abrupt transition between two equilibrium regions. The shortcomings of this model can be rectified by starting from a microscopic physics based equation describing the propagation of phonon waves across an extended junction, with carefully computed thermal boundary conditions on either side. The resulting nonequilibrium Green’s function (NEGF) formalism provides an accurate yet physically transparent machinery to calculate energy transfer, especially in nanosystems where the concept of thermal equilibrium breaks down readily. The purpose of this paper is to establish the NEGF formalism of thermal conductivity with a few simple examples and illustrate its particular strengths compared to the AMM.
Immunoreactivity of Cyclin D1/cdk4 in Neurons and Oligodendrocytes After Focal Cerebral Ischemia in Rat

We investigated the expression of cyclin D1 and its kinase, cdk4, after induction of focal cerebral ischemia in the rat. Brain from rats (n = 6) subjected to 2 hours of transient middle cerebral artery occlusion and 46 hours of reperfusion, and control sham-operated (n = 3) and normal (n = 2) rats were processed for dual label immunohistochemical study for cellular identification of the expression of these cell cycle proteins. Antibodies raised against microtubule-associated protein 2 and neuronal specific enolase for neurons, glial fibrillary acidic protein for astrocytes, myelin basic protein for oligodendrocytes and lectin histochemical study with the B4-isolectin for microglia were used for cell type identification. Double staining for DNA fragmentation detection (TUNEL) and expression of cyclin D1 and cdk4 also was performed. Cyclin D1 and cdk4 were selectively expressed in morphologically intact or altered neurons and oligodendrocytes localized to the ischemic tissue. Apoptotic cells were not immunoreactive to cyclin D1 and cdk4 at 46 hours after 2 hours of middle cerebral artery occlusion. The selective expression of cell cycle proteins observed in nonapoptotic ischemic postmitotic neurons and oligodendrocytes suggests a role for these proteins in cell survival after transient focal cerebral ischemia.
Reliability of fine needle aspiration biopsy in large thyroid nodules.

OBJECTIVE Fine needle aspiration biopsy provides one of the most important data that determines the treatment algorithm of thyroid nodules. Nevertheless, the reliability of fine needle aspiration biopsy is controversial in large nodules. The aim of this study was to evaluate the adequacy of fine needle aspiration biopsy in thyroid nodules that are four cm or greater. MATERIAL AND METHODS We retrospectively examined 219 patients files who underwent thyroidectomy for thyroid nodules that were greater than four centimeter between May 2007 and December 2012. Seventy-four patients with hyperthyroidism, and 18 patients without preoperative fine needle aspiration cytology were excluded from the study. Histopathologic results after thyroidectomy were compared with preoperative cytology results, and sensitivity and specificity rates were calculated. RESULTS False-negativity, sensitivity and specificity rates of fine needle aspiration biopsy of thyroid nodules were found to be 9.7%, 55.5%, and 85%, respectively. Within any nodule of the 127 patients, 28 (22.0%) had thyroid cancer. However, when only nodules of at least 4 cm were evaluated, thyroid cancer was detected in 22 (17.3%) patients. CONCLUSION In this study, fine needle aspiration biopsy of large thyroid nodules was found to have a high false-negativity rate. The limitations of fine-needle aspiration biopsy should be taken into consideration in treatment planning of thyroid nodules larger than four centimeters.
Depression Diagnoses and Fundamental Frequency-Based Acoustic Cues in Maternal Infant-Directed Speech

F0-based acoustic measures were extracted from a brief, sentence-final target word spoken during structured play interactions between mothers and their 3- to 14-month-old infants and were analyzed based on demographic variables and DSM-IV Axis-I clinical diagnoses and their common modifiers. F0 range (ΔF0) was negatively correlated with infant age and number of children. ΔF0 was significantly smaller in clinically depressed mothers and mothers diagnosed with depression in partial remission, relative to nondepressed mothers, mothers diagnosed with depression in full remission, and those diagnosed with depressive disorder not otherwise specified. ΔF0 was significantly lower in mothers experiencing their first major depressive episode relative to mothers with recurrent depression. Deficits in ΔF0 were specific to diagnosed clinical depression, and were not well predicted by elevated self-report scores only or by diagnosed anxiety disorders. Mothers with higher ΔF0 had infants with reportedly larger productive vocabularies, but depression was unrelated to vocabulary development. Implications for cognitive-linguistic development are discussed.