Miracle-dz/UniFAR-FTUs huggingface dataset:
The Relationship between Scores on Ryle's Marital Patterns Test and Independent Ratings of Marital Quality

Summary This study concerns 250 marriages of 40–49 year-old women from a psychiatric patient and general population series. Psychiatric patients' marriages involved less exchange of affection, were husband-dominated, and were of poor quality. In general population marriages, poor quality was related to wife domination. Affection given (AG) and affection received (AR) scores were significantly associated, being high in good marriages and low in bad ones. Zero or near-zero domination was associated with high AG and AR scores and with good quality marriages. Husband domination was linked with wives having high (MMPI) dependency scores. Terminated marriages, compared with bad but non-terminated marriages, had significantly lower AR scores.
Is a Potential Therapeutic Strategy of Periodontal Intervention on Cardiovascular Disease, Yes or No?

Aims: Cardiovascular disease (CVD) and periodontitis are both chronic inflammatory disorders which are highly prevalent in populations. Bacteria involved in the periodontal disease have been found to be cardiovascular risk markers. Periodontal pathogens may contribute to the atheroma pathogenesis. Severe periodontitis is correlated with the prevalence of bacteraemia, and poor periodontal status is an important risk factor for CVD. However, the association is unclear. If the association is causal, the periodontal therapy will lead to an attenuation of the effects on CVD. The study aimed to study if the periodontal intervention therapy presented therapeutic effects on CVD. Methods: English language literature on periodontal intervention therapy on CVD is causal or not. The literature revealed 62 papers associated with this study to investigate the relationship between periodontitis and CVD. Results: The literature supported the idea that periodontal infections had been associated with CVD. Certain periodontal therapy is associated with bacteraemia, and the prevalence of bacteraemia may arise from periodontal therapy and poor oral hygiene practices. Periodontal therapy not only presented therapeutic effects by reducing cytokine activity and C-response protein (CRP), but also caused bacteraemia transitorily. Effective antibiotic prophylaxis pre- or post-periodontal therapy presented some beneficial effects on bacteraemia or CVD. Conclusion: Severe periodontitis causes systemic inflammation and endothelial dysfunction, and goes beyond the oral cavity. Periodontal intervention would contribute to the prevention of atherosclerosis, and antibiotic prophylaxis would be helpful to decrease bacteraemia and reduce the onset of CVD.
Claudin-6, -10d and -10e contribute to seawater acclimation in the euryhaline puffer fish Tetraodon nigroviridis

Expression profiles of claudin-6, -10d and -10e in the euryhaline teleost fish Tetraodon nigroviridis revealed claudin-6 in brain, eye, gill and skin tissue, while claudin-10d and -10e were found in brain, gill and skin only. In fishes, the gill and skin are important tissue barriers that interface directly with surrounding water, but these organs generally function differently in osmoregulation. Therefore, roles for gill and skin claudin-6, -10d and -10e in the osmoregulatory strategies of T. nigroviridis were investigated. In the gill epithelium, claudin-6, -10d and -10e co-localized with Na+-K+-ATPase immunoreactive (NKA-ir) ionocytes, and differences in sub-cellular localization could be observed in hypoosmotic (freshwater, FW) versus hyperosmotic (seawater, SW) environments. Claudin-10d and -10e abundance increased in the gills of fish acclimated to SW versus FW, while claudin-6 abundance decreased in the gills of fish acclimated to SW. Taken together with our knowledge of claudin-6 and -10 function in other vertebrates, data support the idea that in SW-acclimated T. nigroviridis, these claudins are abundant in gill ionocytes, where they contribute to the formation of a Na+ shunt and ‘leaky’ epithelium, both of which are characteristic of salt-secreting SW fish gills. Skin claudin-10d and -10e abundance also increased in fish acclimated to SW versus those in FW, but so did claudin-6. In skin, claudin-6 was found to co-localize with NKA-ir cells, but claudin-10d and -10e did not. This study provides direct evidence that the gill epithelium contains salinity-responsive tight junction proteins that are abundant primarily in ionocytes. These same proteins also appear to play a role in the osmoregulatory physiology of the epidermis.
Investigating communicating sequential processes for Java to support ubiquitous computing

Ubiquitous Computing promises to enrich our everyday lives by enabling the environment to be enhanced via computational elements. These elements are designed to augment and support our lives, thus allowing us to perform our tasks and goals. The main facet of Ubiquitous Computing is that computational devices are embedded in the environment, and interact with users and themselves to provide novel and unique applications. Ubiquitous Computing requires an underlying architecture that helps to promote and control the dynamic properties and structures that the applications require. In this thesis, the Networking package of Communicating Sequential Processes for Java (JCSP) is examined to analyse its suitability as the underlying architecture for Ubiquitous Computing. The reason to use JCSP Networking as a case study is that one of the proposed models for Ubiquitous Computing, the ? -Calculus, has the potential to have its abstractions implemented within JCSP Networking. This thesis examines some of the underlying properties of JCSP Networking and examines them within the context of Ubiquitous Computing. There is also an examination into the possibility of implementing the mobility constructs of the ? -Calculus and similar mobility models within JCSP Networking. It has been found that some of the inherent properties of Java and JCSP Networking do cause limitations, and hence a generalisation of the architecture has been made that should provide greater suitability of the ideas behind JCSP Networking to support Ubiquitous Computing. The generalisation has resulted in the creation of a verified communication protocol that can be applied to any Communicating Process Architecture.
An Investigation of the Onsets of the 1999 and 2000 Monsoons in Central Nepal

Abstract The Marsyandi River basin in the central Nepalese Himalayas is a topographically complex region, with strong spatial gradients of precipitation over various timescales. A meteorological network consisting of 20 stations was installed at a variety of elevations (528–4435 m) in this region, and measurements of rainfall were made during the 1999 and 2000 summer monsoons. The onsets of the 1999 and 2000 monsoons in central Nepal were examined at different spatial scales by using a combination of rain gauge, Meteosat-5, Tropical Rainfall Measuring Mission (TRMM), ECMWF analysis, and Indian radiosonde data. At the network, the onsets manifested themselves as multiday rain events, which included a mixture of stratiform and convective precipitation. Moist and unstable upslope flow was associated with the occurrence of heavy rainfall. During each onset, 2-day rainfall reached as high as 462 mm, corresponding to 10%–20% of the monsoon rainfall. Differences among rain gauges were up to a factor of 8, reflec.
The American Statistical Association statement on P-values explained

421 For better or worse, Null Hypothesis Significance Testing (NHST) with its associated “P” values has become the standard for most published medical literature. However, “P” values are difficult to understand and interpret, even for established researchers. This has led to a lot of unfavorable attention to this issue in the recent past,[1] especially in the context of research misconduct. It has become the perennial butt of scientific cartoonists such as Randall Munroe at http:// xkcd.com [Figure 1]. [2] It is in this background that for the first time in its 177 year history, the American Statistical Association released a “Statement on Statistical Significance and P-values” with six principles. Wasserstein and Lazar have explained the context, process, and purpose of this statement in The American Statistician. [3]
Newborn Hearing Screening: Effectiveness, Importance of High-Risk Factors, and Characteristics of Infants in the Neonatal Intensive Care Unit and Well-Baby Nursery

Background: In contrast to the recommendations of the Joint Committee on Infant Hearing, neonatal hearing screening programs are still not universally available, and many countries implement elective screening in high-risk newborns. Objective: To assess the failure rates of neonates in hearing screening and the relative importance of risk factors for hearing impairment, both in neonatal intensive care units and in well-baby nursery neonates. The impact on cost-effectiveness is also evaluated. Subjects: In the current study, 25,288 newborns were assessed; 23,574 were full-term newborns in the well-baby nursery and 1,714 neonates were in neonatal intensive care units. Methods: All neonates had a general examination (including assessment for congenital anomalies and related history) and were assessed using transient evoked otoacoustic emissions. All newborns were older than 36 weeks at examination and thus had reliable transient evoked otoacoustic emissions. Results: From the 23,574 full-term neonates in the well-baby nursery, 23,123 (98.1%) passed the test and 451 failed (1.9%). Fifty-three of the 23,574 neonates (0.2%) had a risk factor for hearing impairment; 44 (83%) passed the test and 9 failed (17%). Family history of congenital hearing loss and congenital anomalies were the most frequent risk factors for hearing loss. From the 1,714 neonates in neonatal intensive care units, 1,590 (93%) passed the test and 124 failed (7%). Two hundred thirty-two of the 1,714 neonates (14%) had a risk factor for hearing impairment; 205 (88%) passed the test and 27 failed (12%). In neonatal intensive care unit neonates, toxic levels of ototoxic drugs, mechanical ventilation for more than 24 hours, prematurity, and low birth weight were the most frequent risk factors for hearing loss. Congenital anomalies/syndromes were the most important risk factors for failing screening in both the neonatal intensive care unit and the well-baby nursery, as they showed the highest risk of failing hearing screening. The second most important factor in neonatal intensive care unit newborns was low birth weight, and the third was prematurity in relation to the possibility of failing hearing screening. Conclusion: The present study found 575 neonates failing hearing screening of 25,288 tested newborns (2.3%). The fact that 78% of newborns who failed hearing screening were in the well-baby nurseries further supports the necessity of universal hearing screening instead of selective screening in neonatal intensive care units, even with the obvious impact on cost-effectiveness. Even if limited funding lead to selective screening in neonatal intensive care units, this should not be applied to high-risk newborns but to all neonatal intensive care unit neonates. Continuous assessment of risk factors and the related possibility of failing hearing screening are of paramount importance in designing hearing screening programs and refining the respective criteria.
The influence of environmental factors on rugby football injuries

The aim of this study was to establish the influence of weather and pitch conditions on the frequency and nature of rugby injuries. Observers at 26 senior rugby clubs in the Borders District of the Scottish Rugby Union reported all injuries to 1169 (96%) registered players at Saturday home and away matches during the 1993-94 season (August 1993 to April 1994). Weather and pitch conditions at 112 grounds were recorded on 605 occasions; 1268 Borders teams played at these grounds,with 344 injury episodes being sustained. Matches were played in dry weather for three-quarters of these occasions. There was a moderate association between weather and the state of the pitch (Spearman's rank correlation, r = -0.46, P ≪ 0.001), with heavier pitches occurring in wetter weather. Logistic regression revealed that there were significant month-of-season (P = 0.003), wind strength (P = 0.008) and temperature (P = 0.011) effects on the risk of injury. On four of five occasions when matches were played in a downpour of rain, at least one injury episode occurred. Our results show that the month of the season and the weather may influence the occurrence of rugby injuries, but that the state of the pitch does not. Further studies are required to investigate these factors in more detail.
Keep Using My Health Apps: Discover Users' Perception of Health and Fitness Apps with the UTAUT2 Model.

BACKGROUND Health and fitness applications (apps) are one of the major app categories in the current mobile app market. Few studies have examined this area from the users' perspective. This study adopted the Extended Unified Theory of Acceptance and Use of Technology (UTAUT2) Model to examine the predictors of the users' intention to adopt health and fitness apps. MATERIALS AND METHODS A survey (n=317) was conducted with college-aged smartphone users at a Midwestern university in the United States. RESULTS Performance expectancy, hedonic motivations, price value, and habit were significant predictors of users' intention of continued usage of health and fitness apps. However, effort expectancy, social influence, and facilitating conditions were not found to predict users' intention of continued usage of health and fitness apps. CONCLUSIONS This study extends the UTATU2 Model to the mobile apps domain and provides health professions, app designers, and marketers with the insights of user experience in terms of continuously using health and fitness apps.
Seroprevalence and Risk Factors of Sexually Transmitted Infections (HIV, HBV and Syphilis) Among Pregnant Women Provided Health Care Services, Addis Ababa, Ethiopia

Globally the burden of HIV, HBV and Syphilis infections are common problem of pregnant women where its complication isn’t only restricted to the pregnant women rather they are a serious issue for their newborn infants. Compared to developed country, developing countries including Ethiopia have been seriously influenced by such kinds of infections. Therefore this study have designed to determine the sero-prevalence and identify the possible risk factors of HIV, HBV and Syphilis infections in pregnant women providing health care services at Gandhi Memorial Hospital Addis Ababa, Ethiopia from January to April 2014. A Cross sectional study design has used and data on socio-demographic characteristics and possible risk factors have collected through pre-tested and structured questionnaire. After that blood have collected and screened for hepatitis B surface antigen using rapid cassette device and the final positive sample for HBsAg have confirmed by enzyme linked immunosorbent assay (ELISA). Antibodies to HIV-1/2 have tested based on the national testing algorism and Trepollema pallidum antibodies have tested by using Syphilis Rapid Test Strip (Quick Test™ Syphilis Serum/ Plasma/Whole Blood Strip). After the data have entered to Epi Info version 3.5. 1 and exported to SPSS version 16 for validation and analysis, the overall prevalence of HIV-1/2 and HBsAg was 5.2%, 5% respectively while co-infection of HIV-HBV was 9.5% but no cases of Syphilis detected positive. In relation to the risk factors; history of sex with multiple sexual partners, pre-exposure to STI and low level of monthly income were significant risk factors for both HBV and HIV, while each infection found to have additional different risk factors; these includes: receiving of blood through donation, ear piercing and history of abortion for HBV infection while sharing different sharp materials and contact history with infected person for HIV infection alone. Therefore; intensified prevention activities in antenatal care targeting this population will have vital impact in halting the spread of the infections.
Production of transgenic pigs that express porcine endogenous retrovirus small interfering RNAs

Abstract: Background: The presence of multiple copies of porcine endogenous retrovirus (PERV) within the pig genome, and the demonstration that replication competent PERV, that infect human cells in culture, can be isolated from pig cells, directly impacts the drive towards the development of pigs for xenotransplantation. The development of technology to produce pigs that do not propagate PERV has the potential to facilitate the development of xenotransplantation products for human use, and as such, is the focus of this investigation. The shear number of PERV loci, most of which are defective or pseudogenes, renders conventional gene targeting impractical, if not impossible, to inactivate all PERV provirus within the pig genome, including potential replication competent PERV arising from spontaneous recombination. The recently developed RNA interference (RNAi) technology to knockdown/silence post‐transcriptional gene expression, offers a promising alternative to achieving this goal.
ETDM Transmitter Module for 100-Gb/s Ethernet

Performance of a packaged distributed-feedback travelling-wave electroabsorption modulator module for data transmission at 100 Gb/s is presented for the first time. Clearly open eye diagrams at 80 Gb/s with an extinction ratio (ER) of 4.9 dB and 100 Gb/s with ER 4.2 dB (limited by measurement setup) are demonstrated together with data transmission over 100-m-long standard single-mode fiber and over dispersion-compensated 10-km fiber link.
The Economic Impact of Immigration on the Labor Market of Host Countries - Meta-Analytic Evidence

The number of immigrants across the world has doubled since 1980. The estimates of the impact of immigration on wages and employment in host countries are quantitatively small but vary widely. We use meta-regression analysis to show how the estimates vary with definitions of the labor market, the extent of substitutability of foreign and native workers, and controls for endogeneity of immigrant settlement. On average, the impact on employment of the native born is smaller than on wages, and impacts are generally smaller in the U.S. than in other countries studied to date. From the policy perspective, attention must now focus on distributional and long-run productivity effects.
A Self-Adaptive Inertia and Damping Combination Control of VSG to Support Frequency Stability

In the virtual synchronous generator (VSG) field, the traditional methods, such as the constant parameters control method and the self-adaptive inertia control method, always neglect the effect of the damping factor. This letter proposes a self-adaptive inertia and damping combination control method to improve the frequency stability with an interleaving control technique. Tests on the MATLAB/Simulink VSG model demonstrate the effectiveness of the proposed method.
Molecular and Cellular Pathobiology Pancreatic Ductal Adenocarcinoma Mice Lacking Mucin 1 have a Profound Defect in Tumor Growth and Metastasis

MUC1 is overexpressed and aberrantly glycosylated in more than 60% of pancreatic ductal adenocarcinomas. The functional role of MUC1 in pancreatic cancer has yet to be fully elucidated due to a dearth of appropriate models. In this study, we have generated mouse models that spontaneously develop pancreatic ductal adenocarcinoma (KC), which are either Muc1-null (KCKO) or express human MUC1 (KCM). We show that KCKO mice have significantly slower tumor progression and rates of secondary metastasis, compared with both KC and KCM. Cell lines derived from KCKO tumors have significantly less tumorigenic capacity compared with cells from KCM tumors. Therefore, mice with KCKO tumors had a significant survival benefit compared with mice with KCM tumors. In vitro, KCKO cells have reduced proliferation and invasion and failed to respond to epidermal growth factor, platelet-derived growth factor, or matrix metalloproteinase 9. Further, significantly less KCKO cells entered the G2–M phase of the cell cycle compared with the KCM cells. Proteomics and Western blotting analysis revealed a complete loss of cdc-25c expression, phosphorylation of mitogen-activated protein kinase (MAPK), as well as a significant decrease in nestin and tubulin-a2 chain expression in KCKO cells. Treatment with a MEK1/2 inhibitor, U0126, abrogated the enhanced proliferation of the KCM cells but had minimal effect on KCKO cells, suggesting that MUC1 is necessary for MAPK activity and oncogenic signaling. This is the first study to utilize a Muc1-null PDAmouse to fully elucidate the oncogenic role of MUC1, both in vivo and in vitro. Cancer Res; 71(13); 4432–42. 2011 AACR.
Rare complement factor H variant associated with age-related macular degeneration in the Amish.

PURPOSE Age-related macular degeneration is the leading cause of blindness among the adult population in the developed world. To further the understanding of this disease, we have studied the genetically isolated Amish population of Ohio and Indiana. METHODS Cumulative genetic risk scores were calculated using the 19 known allelic associations. Exome sequencing was performed in three members of a small Amish family with AMD who lacked the common risk alleles in complement factor H (CFH) and ARMS2/HTRA1. Follow-up genotyping and association analysis was performed in a cohort of 973 Amish individuals, including 95 with self-reported AMD. RESULTS The cumulative genetic risk score analysis generated a mean genetic risk score of 1.12 (95% confidence interval [CI]: 1.10, 1.13) in the Amish controls and 1.18 (95% CI: 1.13, 1.22) in the Amish cases. This mean difference in genetic risk scores is statistically significant (P = 0.0042). Exome sequencing identified a rare variant (P503A) in CFH. Association analysis in the remainder of the Amish sample revealed that the P503A variant is significantly associated with AMD (P = 9.27 × 10(-13)). Variant P503A was absent when evaluated in a cohort of 791 elderly non-Amish controls, and 1456 non-Amish cases. CONCLUSIONS Data from the cumulative genetic risk score analysis suggests that the variants reported by the AMDGene consortium account for a smaller genetic burden of disease in the Amish compared with the non-Amish Caucasian population. Using exome sequencing data, we identified a novel missense mutation that is shared among a densely affected nuclear Amish family and located in a gene that has been previously implicated in AMD risk.
Pituitary adenylate cyclase-activating polypeptide (PACAP) ameliorates experimental autoimmune encephalomyelitis by suppressing the functions of antigen presenting cells

Pituitary adenylate cyclase-activating polypeptide (PACAP), a 38-amino acid neuropeptide belonging to the secretin-glucagon-vasoactive intestinal peptide (VIP) family, performs a variety of functions in both the nervous and immune systems. In this study, we examined the effects of PACAP on experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice. When administrated intraperitoneally every other day after immunization with myelin oligodendrocyte glycoprotein (MOG) peptide 35 -55, PACAP ameliorated both the clinical and pathological manifestations of EAE. Ex vivo examination revealed a significant inhibition of MOG35 55-specific Th1 response in mice treated with PACAP.In vitro analysis revealed that PACAP suppressed the production of inflammatory cytokines, including TNF-a, IL-1b, and IL-12, and expression of the costimulatory factor B7-2 on macrophage and microglia, which may function as antigen presenting cells (APC) in the CNS. While PACAP suppressed the differentiation of MOG35 55-specific T cells into Th1 effectors upon restimulation with MOG35 55-expressing APC, it did not affect interferon (IFN)-g production by MOG35 55-specific T cells stimulated with anti-CD3 and anti-CD28. These observations suggested that PACAP suppressed induction of EAE primarily via suppression of APC function and inflammatory cytokine production. PACAP may be useful in the future treatment of Th1-mediated autoimmune diseases, such as multiple sclerosis.