Miracle-dz/UniFAR-FTUs huggingface dataset:
The value of practice: A critique of interactional expertise

Collins and Evans have proposed a ‘normative theory of expertise’ as a way to solve the ‘problem of demarcation’ in public debates involving technical matters. Their argument is that all citizens have the right to participate in the ‘political’ phases of such debates, while only three types of experts should have a voice in the ‘technical’ phases. In this article, Collins and Evans’ typology of expertise – in particular, the idea of ‘interactional expertise’ – is the focus of a detailed empirical, methodological and philosophical analysis. As a result, we reaffirm the difference between practitioners and non-practitioners, contesting the four central claims about interactional expertise – namely, that (1) the idea of interactional expertise has been proven empirically, (2) it is possible to develop interactional expertise through ‘linguistic socialization alone’, (3) the idea of interactional expertise supports the ‘the minimal embodiment thesis’ that the individual human body or, more broadly, ‘embodiment’ is not as relevant as linguistic socialization for acquiring a language and (4) interactional experts have the same linguistic fluency, understanding and judgemental abilities of practitioners within discursive settings. Instead, we argue, individuals’ abilities and understandings vary according to the ‘type of immersion’ they have experienced within a given practice and whether they bring with them another ‘perspective’. Acknowledging these differences helps with demarcation but does not solve the ‘problem of demarcation’. Every experience is perspectival and cannot handle, alone, the intertwined and complex issues found in public debates involving technical matters. The challenge, then, concerns the ways to mediate interactions between actors with distinct perspectives, experiences and abilities.
Bibliometrics of anaesthesia researchers in the UK.

BACKGROUND Bibliometrics provide surrogate measures of the quality and quantity of research undertaken by departments and individuals. Previous reports have suggested that academic anaesthesia research in the UK is in decline. We wished to provide a comprehensive description of current and historical published output of UK anaesthesia researchers. METHODS Bibliometric indices (Web of Science(®)) were calculated for anaesthesia researchers in the UK for the whole period covered by the database, and for 2004-8. A parallel search was made using the Scholarometer™ tool, which parses output from Google Scholar™. Calculated indices included total number of publications; total number of citations; citations per paper; h-index; g-index; and modified impact index. RESULTS One hundred and four individuals and 23 academic departments were identified. Median values (inter-quartile range) for the indices were: total papers 57 (24-95) (individuals for the whole period), 11 (6-20) (individuals 2004-8), 50 (30-70) (departments 2004-8); total number of citations 571 (175-1328), 93 (38-207), 383 (239-845); h-index 13 (8-20), 6 (3-8), 11 (9-14). Four departments were ranked in the top 5 for all indices. CONCLUSIONS The general distribution of bibliometric data is similar to that seen in other specialities in Europe and North America. Four departments contribute to more than 50% of published anaesthesia research output in this data set. These data provide useful comparative tools for individuals, departments, and national bodies.
The unprecedented coupled ocean-atmosphere summer heatwave in the New Zealand region 2017/18: drivers, mechanisms and impacts

During austral summer (DJF) 2017/18, the New Zealand region experienced an unprecedented coupled ocean-atmosphere heatwave, covering an area of 4 million km2. Regional average air temperature anomalies over land were +2.2 °C, and sea surface temperature anomalies reached +3.7 °C in the eastern Tasman Sea. This paper discusses the event, including atmospheric and oceanic drivers, the role of anthropogenic warming, and terrestrial and marine impacts. The heatwave was associated with very low wind speeds, reducing upper ocean mixing and allowing heat fluxes from the atmosphere to the ocean to cause substantial warming of the stratified surface layers of the Tasman Sea. The event persisted for the entire austral summer resulting in a 3.8 ± 0.6 km3 loss of glacier ice in the Southern Alps (the largest annual loss in records back to 1962), very early Sauvignon Blanc wine-grape maturation in Marlborough, and major species disruption in marine ecosystems. The dominant driver was positive Southern Annular Mode (SAM) conditions, with a smaller contribution from La Niña. The long-term trend towards positive SAM conditions, a result of stratospheric ozone depletion and greenhouse gas increase, is thought to have contributed through association with more frequent anticyclonic ‘blocking’ conditions in the New Zealand region and a more poleward average latitude for the Southern Ocean storm track. The unprecedented heatwave provides a good analogue for possible mean conditions in the late 21st century. The best match suggests this extreme summer may be typical of average New Zealand summer climate for 2081–2100, under the RCP4.5 or RCP6.0 scenario.
Human papillomavirus‐associated plantar epidermoid cyst related to epidermoid metaplasia of the eccrine duct epithelium: a combined histological, immunohistochemical, DNA–DNA in situ hybridization and three‐dimensional reconstruction analysis

Background We recently proposed that certain palmoplantar epidermoid cysts may be related to eccrine ducts and that human papillomavirus (HPV) 60 may play a role in their pathomechanism. However, the origin of palmoplantar epidermoid cysts is still controversial.
Mechanisms of biosorption of different heavy metals by brown marine macroalgae

The biosorption mechanisms of different heavy metallic cations (Cd, Ni, Pb) to active chemical groups on the cell wall matrix of the nonliving brown marine macroalga, Sargassum vulgaris in its natural form, were examined by the following instrumental and chemical techniques: Fourier‐transform infrared (FTIR) analysis, X‐ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), and extraction of alginic acid and sulfated polysaccharides, which act as metal‐binding moieties present in cell wall. From the different techniques used and the known chemical composition of the algal cell wall, it was observed that biosorption of the metallic cations to the algal cell wall component was a surface process. The binding capacities of the different metal cations were between 1 and 1.2 mmol metal/g on a dry weight basis. The main chemical groups involved in the metallic cation biosorption were apparently carboxyl, amino, sulfhydryl, and sulfonate. These groups were part of the algal cell wall structural polymers, namely, polysaccharides (alginic acid, sulfated polysaccharides), proteins, and peptidoglycans. The main cadmium cation sequestration mechanism by the algal biomass was apparently chelation, while the nickel cation sequestration mechanism was mainly ion exchange. Lead cations exhibit higher affinity to the algal biomass, and their binding mechanism included a combination of ion exchange, chelation, and reduction reactions, accompanied by metallic lead precipitation on the cell wall matrix. During the ion exchange process, calcium, magnesium, hydrogen cations, and probably other cations (sodium and potassium) in the algal cell wall matrix were replaced by the tested heavy metals. © 2004 Wiley Periodicals, Inc.
Antitumor activity of water extract of a mushroom, Inonotus obliquus, against HT‐29 human colon cancer cells

In the current study, it was demonstrated that the hot water extract of I. obliquus (IOWE) exerts inhibitory activity against the proliferation of human colon cancer cells (HT‐29). The inhibitory effect of IOWE on the growth of HT‐29 cancer cells was evaluated by treating cells with IOWE at concentrations of 0.25, 0.5 and 1.0 mg/mL for 24 or 48 h. The IOWE inhibited cell growth in a dose‐dependent manner, and this inhibition was accompanied by apoptotic cell death. The maximum inhibitory effect (56%) was observed when IOWE was treated at a concentration of 1.0 mg/mL for 48 h. The apoptotic effect of IOWE on HT‐29 cells was also confirmed by flow cytometric analysis. In addition, the apoptotic cell percentage was closely associated with down‐regulation of Bcl‐2 and up‐regulation of Bax and caspase‐3. The results suggest that IOWE would be useful as an antitumor agent via the induction of apoptosis and inhibition of the growth of cancer cells through up‐regulation of the expression of proapoptotic proteins and down‐regulation of antiapoptotic proteins. Copyright © 2009 John Wiley & Sons, Ltd.
Quality-aware network dimensioning for the VoIP service

Current networks are multi-service packet-switched environments, very often based on Internet Protocol, where the provision of good quality services is a great challenge. The most popular service, offered by almost every network, is voice transmission. As a real-time service, it places high demands on bandwidth and delay. The paper describes selected network dimensioning problems for the voice over IP service. The authors discuss service quality measures in legacy circuit switched networks and the key performance indicators that influence the quality of telephone service in packet networks. The main contribution of the paper is the proposal of utilizing the blocking probability calculation, which is based on the B-Erlang model used in legacy systems, to estimate the average bandwidth needed to handle a number of sources generating voice traffic in IP networks. Taking into account the average bandwidth required to carry out a one voice conversation, the total network capacity was calculated. The authors made analytical calculations which were confirmed by simulation studies. The problem of using different codecs and their influence on bandwidth consumption and overall service quality experienced by a user were also discussed in the paper. At the end of the paper, the authors defined the directions of further research that should be carried out, i.e. the development of dimensioning methods for networks carrying multimedia services with particular attention paid to video transmission and reliable quality assessment.
Functional and Cognitive Impairment, Frailty, and Adverse Health Outcomes in Older Patients Reaching ESRD-A Systematic Review.

BACKGROUND AND OBJECTIVES Older patients reaching ESRD have a higher risk of adverse health outcomes. We aimed to determine the association of functional and cognitive impairment and frailty with adverse health outcomes in patients reaching ESRD. Understanding these associations could ultimately lead to prediction models to guide tailored treatment decisions or preventive interventions. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS We searched MEDLINE, Embase, Web of Science, CENTRAL, CINAHL, PsycINFO, and COCHRANE for original studies published until February 8, 2016 reporting on the association of functional or cognitive impairment or frailty with adverse health outcome after follow-up in patients reaching ESRD either with or without RRT. RESULTS Of 7451 identified citations, we included 30 articles that reported on 35 associations. Mean age was >60 years old in 73% of the studies, and geriatric conditions were highly prevalent. Twenty-four studies (80%) reported on functional impairment, seven (23%) reported on cognitive impairment, and four (13%) reported on frailty. Mortality was the main outcome measure in 29 studies (97%), and one study assessed functional status trajectory. In 34 of 35 (97%) associations reported, functional or cognitive impairment or frailty was significantly and independently associated with adverse health outcomes. The majority of studies (83%) were conducted in selected patient populations, mainly patients on incident dialysis. CONCLUSIONS Functional and cognitive impairment and frailty in patients reaching ESRD are highly prevalent and strongly and independently associated with adverse health outcomes, and they may, therefore, be useful for risk stratification. More research into their prognostic value is needed.
Treatment of deep venous thrombosis with low-molecular-weight heparins. A meta-analysis.

BACKGROUND An intravenous course of unfractionated heparin adjusted on the basis of the activated partial thromboplastin time is the initial treatment of choice for most patients with venous thromboembolism. Recently introduced low-molecular-weight heparin preparations can be administered subcutaneously, once or twice daily, without laboratory monitoring. We quantitatively assessed the relative efficacy and safety of low-molecular-weight heparin vs standard heparin for the initial treatment of deep venous thrombosis. METHODS English-language reports of randomized trials were identified through a MEDLINE search (1984 through 1994) and a complementary extensive manual search. Reasons for exclusion from the analysis were no heparin dosage adjustments, the lack of use of objective tests for deep venous thrombosis, duplicate reports, preliminary reports of data later presented in full, dose-ranging studies that used higher doses of low-molecular-weight heparin than are currently in use, and the failure to provide blind end-point assessment. We assessed the incidence of symptomatic recurrent venous thromboembolic disease, the incidence of clinically important bleeding, and mortality. RESULTS Ten of the 19 identified trials satisfied the predetermined criteria. The relative risk reductions for symptomatic thromboembolic complications (53% [95% confidence interval, 18% to 73%]), clinically important bleeding (68% [95% confidence interval, 31% to 85%]), and mortality (47% [95% confidence interval, 10% to 69%]) were all statistically significantly in favor of low-molecular-weight heparin. CONCLUSIONS Low-molecular-weight heparins administered subcutaneously in fixed doses adjusted for body weight and without laboratory monitoring are more effective and safer than adjusted-dose standard heparin. Since low-molecular-weight heparins may not be interchangeable and the conclusions of our meta-analysis are based mainly on the findings of three trials that used two different low-molecular-weight heparins, definitive randomized controlled trials for the other low-molecular-weight heparins are required.
A comparison of gray and white matter density in patients with Parkinson's disease dementia and dementia with Lewy bodies using voxel‐based morphometry

Despite clinical and neuropsychological similarities between Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB), recent studies have demonstrated that structural and pathological changes are more severe in DLB than in PDD. We used voxel‐based morphometry using a 3‐T MRI scanner to compare gray and white matter densities in 20 patients with probable PDD and 18 patients with probable DLB, who had similar overall severity of dementia and similar demographic characteristics. The gray matter density was significantly decreased in the left occipital, parietal, and striatal areas in patients with DLB compared with patients with PDD. The white matter density was significantly decreased in bilateral occipital and left occipito‐parietal areas in patients with DLB compared with those with PDD. The degree of white and gray matter atrophy was similar in patients with DLB; in contrast, there was markedly less atrophy in the white matter than in the gray matter in patients with PDD. On analyzing the change of WM density relative to that of GM density in patients with DLB compared to those with PDD, the area of WM atrophy in the occipital areas was more extensive than that of GM atrophy. Our data demonstrate that atrophy of both gray and white matter was more severe in patients with DLB and that white matter atrophy relative to gray matter atrophy was less severe in patients with PDD. These data may reflect a difference in the underlying nature of PDD and DLB. © 2009 Movement Disorder Society
Identification of the Most Abundant Lactobacillus Species in the Crop of 1- and 5-Week-Old Broiler Chickens

ABSTRACT Bacteria from crops of 1- and 5-week-old broiler chickens fed with two brands (diets A and B) of wheat-based diets were isolated on Lactobacillus-selective medium and identified (n = 300) based on partial 16S rRNA gene sequence. The most abundant Lactobacillus species were L. reuteri (33%), L. crispatus (18.7%), and L. salivarius (13.3%). Regardless of farm and feed, L. reuteri was the most abundant species (P < 0.005) in the crops of the younger chickens. However, the amount of L. reuteri was significantly reduced in the crops of the 5-week-old chickens regardless of the feed (P = 0.016). The diversity of L. reuteri isolates was studied by fatty acid analysis, and the 94 L. reuteri isolates could be arranged into several clusters. The nisin sensitivities of the L. reuteri isolates were determined because nisin is a candidate coccidiostat. Sensitive isolates were found more frequently in younger chickens (77%) than in 5-week-old chickens (23%), whereas chickens fed with commercial feed B had a higher proportion of nisin-resistant isolates (73%) than did chickens fed with feed A (45%). Nisin-resistant strains are potential candidates for adjunct cultures for maintaining L. reuteri in its natural niche in the crop and are potential targets for genetic engineering with nisin-selectable food-grade vectors. The diversity of the L. reuteri population suggested that one should consider including several strains representing different clusters and nisin resistance phenotypes in candidate probiotic feed supplements for chickens.
Breech delivery at term: A critical review of the literature

Objective: To determine whether planned vaginal or elective cesarean delivery is better for singleton term breech infants. Data sources: Articles that included singleton term pregnancies with breech presentation published in English between 1966 and September 1992 were searched through the Index Medicus, Oxford Database of Perinatal Trials, and MEDLINE. Methods of study selection: We reviewed 24 studies that presented results according to the intended mode of delivery in terms of the following adverse outcomes: perinatal mortality, low 5‐minute Apgar score, traumatic neonatal morbidity, overall short‐term neonatal morbidity, long‐term infant morbidity, and maternal morbidity and mortality. Data extraction and synthesis: The effect of planned vaginal delivery, compared with planned cesarean delivery, for each adverse outcome was determined by calculating a typical odds ratio. Perinatal mortality was higher for the planned vaginal delivery groups than for the elective cesarean groups, with a typical odds ratio of 3.86 (95% confidence interval [CI] 2.22‐6.69). Neonatal morbidity due to trauma was also higher for the planned vaginal delivery groups, with a typical odds ratio of 3.96 (95% CI 2.76‐5.67). Conclusion: The results suggest that planned vaginal delivery may be associated with higher perinatal mortality and morbidity rates than planned cesarean delivery. Because of selection bias in the majority of studies, differences in outcomes may be due to factors other than the planned method of delivery. An appropriately sized, randomized controlled trial is needed to answer this question definitively. (Obstet Gynecol 1993;82:605‐18)
Microsomal and cytosolic biotransformation of aflatoxin B1 in four poultry species

1. This research evaluated differences in hepatic in vitro metabolism of aflatoxin B1 (AFB1) on selected avian species. 2. Microsomal and cytosolic liver fractions were obtained from chickens, ducks, quails and turkeys; eight males and eight females of each. 3. All microsomes studied produced AFB1-8,9-exo-epoxide (AFBO), a metabolite regarded as the active product of AFB1. Turkey microsomes produced 1·8 and 3·5 times more AFBO than quails and chickens microsomes, respectively. 4. Males from evaluated birds produced more AFBO than females, but statistically-significant differences between genders were observed only in ducks and turkeys. 5. The cytosolic fraction from all four species produced aflatoxicol (AFL). Turkey and duck hepatic cytosol produced more AFL than from quail and chickens. 6. It is known that turkeys are very sensitive to AFB1, quails are intermediate and chickens are particularly resistant; the differences in AFBO production shown in our study may help to explain the different in vivo responses among turkeys, quail and chickens. 7. Moreover, AFL may be related to AFB1 toxicity; it was produced in larger amounts by hepatic cytosol from the more susceptible species. 8. Because AFBO production by microsomes in ducks was relatively low, it is possible that other toxicity mechanisms are involved in this highly susceptible species.
Mathematical Model of Acute Myeloblastic Leukaemia: an Investigation of the Relevant Kinetic Parameters

A simple model of acute myeloblastic leukaemia (AML) development is introduced, explicitly including cell growth, cell differentiation and cell‐cell interaction. Each of these processes is described by a single model parameter. It is hypothesized that the leukaemic cell is characterized by an alteration of only one of these processes. the kinetic behaviour of the AML system is examined separately for possible alterations of each of the three parameters describing the three processes involved. It is shown that, on the basis of the existing data on AML kinetics, the alteration of the growth and cell‐cell interaction parameters can be eliminated as a possible source of AML. Thus kinetic data support the modification of the differentiation process as the origin of the AML state. Further, the growth characteristics of normal and leukaemic cells in the presence of each other are analysed. It is shown how the initial growth of leukaemic cells depends on the difference in the differentiation of normal and leukaemic cells and how the same difference determines the decay of normal cells in the presence of the predominantly leukaemic population. Correlations between the kinetic parameters of the normal and leukaemic populations are suggested to characterize the leukaemic state.
Effect of the Use of Multimedia on Students' Performance: A Case Study of Social Studies Class.

The rapidly changing technological developments have affected education as it does every other fields of human endeavor. The number of technology applications used in education increases every day. One of these tools is multimedia. In the studies about the use of multimedia in education, it has been reached that multimedia increases students’ success, affects students’ attitudes in the positive way and makes lessons more enjoyable and understandable. In this study, multimedia tools were used in social studies to contribute to the field. The study aims to outline the effect of multimedia on the academic success of social studies students. Experimental design was used in the study with two sections (both 4th grade – Section I as the control group and Section II as the experimental group) used as the control and experimental study groups of this study. The sample of the study is 67 social studies 4th grade students in Kayseri, Turkey. For data collection, an achievement test which was generated with experts’ opinion and tried as pilot was used. The data from the achievement test was analyzed with SPSS program. At the end of the study, it has been concluded that multimedia technique increased the academic success of students in social studies lesson compared to the traditional classroom. Key words: Multimedia, computer aided education, social studies, technology usage.