Miracle-dz/UniFAR-FTUs huggingface dataset:
South Asian Ethnicity and Cardiovascular Risk

South Asians (SAs), in their countries or after migration, are at high risk of coronary artery disease (CAD) and mortality compared to other ethnic groups. It has been shown that >90% of CAD global risk could be attributed to 9 modifiable risk factors (RFs) worldwide. However, these conventional RFs may not fully explain this high risk of CAD among SAs. Therefore, attention has been directed toward nonconventional RFs. In this narrative review, we evaluate the conventional and emerging cardiovascular RFs characterizing SAs. These factors may explain the high morbidity and mortality among SAs. Further prospective studies are urgently needed to set algorithms for the optimal management of these RFs in high-risk populations like SAs.
Macrocerebellum: Neuroimaging and Clinical Features of a Newly Recognized Condition

Other than hamartomatous enlargement of the cerebellum as in Lhermitte-Duclos syndrome, diffuse enlargement of the cerebellum is not clearly described. We report four patients (ages 9 months to 2 years) with diffusely enlarged cerebelli as identified by measurement of the cerebellum and comparison to age appropriate normal values. The cerebellar measurements were determined in absolute numbers and expressed as ratios of cerebellum to whole brain and supratentorial brain. The clinical features of these four children (3 boys, 1 girl) consistently include global developmental delay, tone abnormalities, preserved reflexes, delayed or abnormal maturation of the visual system (oculomotor apraxia), and deficient or delayed myelination of cerebral white matter. The etiology of the macrocerebellum is unknown but we propose that the cerebellum is responding to the elaboration of growth factors intended to augment the slow development of cerebral structures. Regardless of the etiology, the finding of a macrocerebellum appears to allow the clinician to predict the clinical features of the patient and probably represents a marker for disturbed cerebral development. (J Child Neurol 1997;12:365-368).
A Case Report of Acute Transverse Myelitis Following Novel Coronavirus Infection

Introduction During the coronavirus disease 2019 (COVID-19) pandemic, emergency providers are not only seeing an increasing number of patients with COVID-19 infections, but also associated complications and sequelae of this viral illness. Case Report We present the case of a 28-year-old female patient who presented after a confirmed COVID-19 infection with lower back pain, bilateral symmetric upper and lower extremity numbness, and urinary retention. The patient was diagnosed with acute transverse myelitis. She required intravenous corticosteroids and plasma exchange with significant improvement in symptoms and minimal residual effects. Conclusion This case illustrates the importance of prompt recognition and treatment of sequelae of COVID-19 infections.
How should we manage fibromyalgia?

Dual energy x ray absorptiometry (DXA) is the most commonly used method of measuring bone mineral density (BMD); it has been shown to be a good predictor of the future risk of fracture.1Unfortunately, the generalised use of DXA is limited as it is expensive and time consuming, is not portable, and is available only in specialised clinics. Computed digital absorptiometry (CDA) of the hand is a new bone densitometry technique, designed to assess the BMD of the middle phalanx of the third finger using a direct, automated measurement of x ray attenuation.2This technique is similar to radiographic absorptiometry but provides immediate results; in current radiographic absorptiometry, radiographs are sent to an off site processing centre and the results are received a few days later. CDA is cheap and quick. Its precision and accuracy seem to be acceptable, but its ability to discriminate between patients with osteoporosis and normal subjects, to predict risk of …
A case report of mumps keratitis.

A case of mumps keratitis with iritis is presented illustrating the rapid recovery that can occur with this entity. Report of Case A 14-year-old white female was seen at the Bascom Palmer Eye Institute complaining of hazy vision in the left eye of two days' duration. Two days prior to admission, the patient awoke and noted that the left eye was "bloodshot. " As the day progressed, vision in the left eye became hazy. There was no pain. Tearing and photophobia were present but were not marked. Five days prior to the onset of eye symptoms, the patient was seen by her physician because of rhinorrhea and a painless swelling in the region of the left submaxillary gland. The swelling subsided in two days. There was no history of eye trauma or familial disease. Positive physical findings were limited to the eyes. The right eye was completely normal. The left eye
Drosophila DBT Lacking Protein Kinase Activity Produces Long-Period and Arrhythmic Circadian Behavioral and Molecular Rhythms

ABSTRACT A mutation (K38R) which specifically eliminates kinase activity was created in the Drosophila melanogaster ckI gene (doubletime [dbt]). In vitro, DBT protein carrying the K38R mutation (DBTK/R) interacted with Period protein (PER) but lacked kinase activity. In cell culture and in flies, DBTK/R antagonized the phosphorylation and degradation of PER, and it damped the oscillation of PER in vivo. Overexpression of short-period, long-period, or wild-type DBT in flies produced the same circadian periods produced by the corresponding alleles of the endogenous gene. These mutations therefore dictate an altered “set point” for period length that is not altered by overexpression. Overexpression of the DBTK/R produced effects proportional to the titration of endogenous DBT, with long circadian periods at lower expression levels and arrhythmicity at higher levels. This first analysis of adult flies with a virtual lack of DBT activity demonstrates that DBT's kinase activity is necessary for normal circadian rhythms and that a general reduction of DBT kinase activity does not produce short periods.
Adjusting for the Confounding Effects of Treatment Switching-The BREAK-3 Trial: Dabrafenib Versus Dacarbazine.

BACKGROUND Patients with previously untreated BRAF V600E mutation-positive melanoma in BREAK-3 showed a median overall survival (OS) of 18.2 months for dabrafenib versus 15.6 months for dacarbazine (hazard ratio [HR], 0.76; 95% confidence interval, 0.48-1.21). Because patients receiving dacarbazine were allowed to switch to dabrafenib at disease progression, we attempted to adjust for the confounding effects on OS. MATERIALS AND METHODS Rank preserving structural failure time models (RPSFTMs) and the iterative parameter estimation (IPE) algorithm were used. Two analyses, "treatment group" (assumes treatment effect could continue until death) and "on-treatment observed" (assumes treatment effect disappears with discontinuation), were used to test the assumptions around the durability of the treatment effect. RESULTS A total of 36 of 63 patients (57%) receiving dacarbazine switched to dabrafenib. The adjusted OS HRs ranged from 0.50 to 0.55, depending on the analysis. The RPSFTM and IPE "treatment group" and "on-treatment observed" analyses performed similarly well. CONCLUSION RPSFTM and IPE analyses resulted in point estimates for the OS HR that indicate a substantial increase in the treatment effect compared with the unadjusted OS HR of 0.76. The results are uncertain because of the assumptions associated with the adjustment methods. The confidence intervals continued to cross 1.00; thus, the adjusted estimates did not provide statistically significant evidence of a treatment benefit on survival. However, it is clear that a standard intention-to-treat analysis will be confounded in the presence of treatment switching-a reliance on unadjusted analyses could lead to inappropriate practice. Adjustment analyses provide useful additional information on the estimated treatment effects to inform decision making. IMPLICATIONS FOR PRACTICE Treatment switching is common in oncology trials, and the implications of this for the interpretation of the clinical effectiveness and cost-effectiveness of the novel treatment are important to consider. If patients who switch treatments benefit from the experimental treatment and a standard intention-to-treat analysis is conducted, the overall survival advantage associated with the new treatment could be underestimated. The present study applied established statistical methods to adjust for treatment switching in a trial that compared dabrafenib and dacarbazine for metastatic melanoma. The results showed that this led to a substantially increased estimate of the overall survival treatment effect associated with dabrafenib.
A Survey

: As Cloud computing turns out to be more prominent, comprehension the financial aspects of Cloud computing turns out to be basically critical. To amplify the benefit, an administration supplier ought to comprehend both administration charges and business costs, and how they are dictated by the qualities of the applications and the arrangement of a multi-server framework. The issue of ideal multi-server setup revenue driven augmentation in a Cloud computing environment is considered. Our valuing model takes such figures contemplations as the measure of an administration, the workload of an application situation, the setup of a multi-server framework, the service-level agreement, the fulfillment of a buyer, the nature of an administration, the punishment of a low-quality administration, the expense of leasing, the expense of vitality utilization, and an administration supplier's edge and benefit. Our methodology is to regard a multi-server framework as a M/M/m lining model, such that our streamlining issue can be figured and illuminated logically. Two server speed and power utilization models are considered, to be specific, the unmoving pace model and the consistent pace model. The likelihood thickness capacity of the waiting time of a newly arrived service request is derived. The expected service charge to a service request is calculated.
Health Outcomes of International HIV-infected Adoptees in the US

Background: International adoption of HIV-infected children is becoming increasingly common. Their health has not yet been described. Methods: HIV-infected international adoptees or refugees in foster care aged 0–20 years followed at Seattle Children’s Hospital or Children’s Hospital Colorado between January 1, 2004 and May 31, 2013 were included. Parameters were collected through retrospective chart review of baseline (first 6 months at study site) and annual follow-up visits. Results: Africa (90%) was the primary region of origin for the 79 children who met inclusion criteria. Median follow-up was 3 years (range: 0–7). At baseline, acute malnutrition was uncommon (8%); however, stunting occurred in 32%. Most stunting resolved during the study period. The most common medical issues at baseline were dermatologic (Tinea and Molluscum contagiosum) and gastrointestinal (parasites and diarrhea). Almost half (48%) had either mental health issues or behavioral problems. Educational delays (50%) were also common. Upon adoption, only 1% was severely (CD4% < 15%) immunosuppressed. Fifty-nine (75%) were on antiretroviral therapy (ART); 45 of these (76%) had suppressed viral load (VL). Of 14 children on ART with detectable VL, 11 (79%) demonstrated non-nucleoside reverse transcriptase inhibitor resistance and 1 (7%) protease inhibitor resistance. Conclusions: In this cohort of HIV-infected international adoptees, severe immunosuppression was uncommon. Most medical issues were mild. Stunting was common at baseline but largely resolved. Mental health issues, behavioral problems, and educational delays were common. Most children were on ART at adoption and most of these showed suppressed VL. Non-nucleoside reverse transcriptase inhibitor mutations were present in most viremic children.
Sensorimotor pathways involved in interjoint reflex action of an insect leg.

Coordination of motor output between leg joints is crucial for the generation of posture and active movements in multijointed appendages of legged organisms. We investigated in the stick insect the information flow between the middle leg femoral chordotonal organ (fCO), which measures position and movement in the femur-tibia (FT) joint and the motoneuron pools supplying the next proximal leg joint, the coxa-trochanteral (CT) joint. In the inactive animal, elongation of the fCO (by flexing the FT joint) induced a depolarization in eight of nine levator trochanteris motoneurons, with a suprathreshold activation of one to three motoneurons. Motoneurons of the depressor trochanteris muscle were inhibited by fCO elongation. Relaxation signals, i.e., extension of the FT joint, activated both levator and depressor motoneurons; i.e., both antagonistic muscles were coactivated. Monosynaptic as well as polysynaptic pathways contribute to interjoint reflex actions in the stick insect leg. fCO afferents were found to induce short latency EPSPs in levator motoneurons, providing evidence for direct connections between fCO afferents and levator motoneurons. In addition, neuronal pathways via intercalated interneurons were identified that transmit sensory information from the fCO onto levator and/or depressor motoneurons. Finally, we describe two kinds of alterations in interjoint reflex action: (a) With repetitive sensory stimulation, this interjoint reflex action shows a habituation-like decrease in strength. (b) In the actively moving animal, interjoint reflex action in response to fCO elongation, mimicking joint flexion, qualitatively remained the same sign, but with a marked increase in strength, indicating an increased influence of sensory signals from the FT joint onto the adjacent CT joint in the active animal.
Enhanced ultraviolet cancellations in N = 5 supergravity at four loops

We show that the four-loop four-point amplitudes of N = 5 supergravity are ultraviolet finite in four dimensions, contrary to expectations based on supersymmetry and duality-symmetry arguments. We explain why the diagrams of any covariant local formalism cannot manifestly exhibit the necessary cancellations for finiteness but instead require a new type of nontrivial ultraviolet cancellation that we call "enhanced cancellations". We also show that the three-loop four-point amplitudes in N = 4 and N = 5 supergravity theories display enhanced cancellations. To construct the loop integrand, we use the duality between color and kinematics. We apply standard methods for extracting ultraviolet divergences in conjunction with the FIRE5 integral reduction program to arrive at the four-loop results.
Intravenous Propafenone Versus Intravenous Amiodarone in the Management of Atrial Fibrillation of Recent Onset: A Placebo‐Controlled Study

The efficacy and safety of intravenous propafenone, amiodarone, or placebo were compared in the treatment of atrial fibrillation (AF) of recent onset (duration ≤ 48 hours). Methods: 143 patients (77 men, mean age 63 ± 12 years) were studied, of whom 46 received propafenone (2 mg/kg over 15 minutes followed by 10 mg/kg over the next 24 hours), 48 received amiodarone (300 mg intravenously over 1 hour, followed by 20 mg/kg over the next 24 hours, plus 1,800 mg/day orally, in 3 divided doses), and 49 received placebo (the equivalent amount of saline IV over 24 hours). Digoxin was administered to all patients who had not previously received it. Results: Conversion to normal sinus rhythm occurred in 36 of 46 patients (78.2%) receiving propafenone, in 40 of 48 patients (83.3%) receiving amiodarone, and in 27 of the 49 (55.10%) controls (P < 0.02, drug vs placebo, between drugs NS). The mean time to conversion was 2 ± 3 hours for propafenone, 7 ± 5 hours for amiodarone, and 13 ± 9 for placebo (P < 0.05). Patients who converted had smaller atria than those who did not (diameter: 42.7 ± 5 vs 47.2 ± 7 mm, P < 0.001 for all). Treatment was discontinued in one patient in the amiodarone group because of an allergic reaction and in two patients in the propafenone group because of excessive QRS widening. No side effects were observed in the placebo group. Conclusions: Both drugs tested intravenously were equally effective and safe for the rapid conversion of recent‐onset atrial fibrillation to sinus rhythm. However, propafenone offered the advantage of more rapid conversion than amiodarone.
Thalassemia β0 due to an identical frameshift mutation, codon 15 (−T) in both parents

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Altered bile acid profiles in duodenal bile and urine in diabetic subjects

Abstract. The bile acid composition in duodenal bile was analysed in 22 diet‐treated and 11 insulin‐treated middle‐aged patients with diabetes mellitus and in 20 normoglycaemic controls. In 10 subjects with diabetes mellitus the bile acid profile in urine was also investigated. In the non‐insulin‐dependent diabetic patients the percentage of cholic acid was reduced and that of deoxycholic acid increased. As a highly significant finding there was a three‐fold increase of the percentage of 12‐ketolithocholic acid in duodenal bile in non‐insulin‐dependent diabetics, whereas the bile acid composition in insulin‐dependent diabetics was similar to that in a control group.
Measuring Abdominal Adipose Tissue: Comparison of Simpler Methods with MRI

Objective: This cross-sectional study compares the relationship of visceral and total abdominal adipose tissue (VAT and TAAT) measurements obtained with magnetic resonance imaging (MRI) and a range of ‘simpler’ techniques suitable for field or bedside use: BMI, waist circumference (WC), bioelectrical impedance (BIA) devices and dual X-ray absorptiometry (DXA). Method: 120 participants were recruited, stratified by gender and BMI (20 men and 20 women within each group: lean, overweight and obese). Measurements included height, weight, WC (at midpoint), DXA L2-L4 fat, and BIA (two whole-body and one abdominal device). MRI was used as the reference. Results: MRI data showed that men have more VAT than women, (mean 147 vs. 93 cm2) despite less TAAT (362 vs. 405 cm2). Correlations of simpler abdominal fat measures showed significantly higher correlations with TAAT than with VAT in men and women. Similarly, trunk and whole-body fat measures were significantly more strongly correlated with TAAT than with VAT. Conclusion: None of the simpler techniques show strong correlations with VAT measured by MRI, but WC, abdominal BIA ‘visceral fat level’ and DXA L2-L4 fat all show similar and strong correlations with TAAT and may be useful in large scale surveys.
Manipulating space: modelling the role of transient dynamics in inattentional blindness

According to Noë’s enactive theory of perception, sensorimotor knowledge allows us to predict the sensory outcomes of our actions. This paper suggests that tuning input filters with such predictions may be the cause of sustained inattentional blindness. Most models of learning capture statistically salient regularities in and between data streams. Such analysis is, however, severely limited by both the problem of marginal regularity and the credit assignment problem. A neurocomputational reservoir system can be used to alleviate these problems without training by enhancing the separability of regularities in input streams. However, as the regularities made separable vary with the state of the reservoir, feedback in the form of predictions of future sensory input can both enhance expected discriminations and hinder unanticipated ones. This renders the model blind to features not made separable in the regions of state space the reservoir is manipulated towards. This is demonstrated in a computational model of sustained inattentional blindness, leading to predictions about human behaviour that have yet to be tested.
Vitamin D and autoimmunity

Objectives: To review and evaluate the role of vitamin D in autoimmune diseases based on current studies. Method: We searched PubMed using keywords such as ‘vitamin D’, ‘autoimmune disease’, and ‘autoimmunity’. We compiled and reviewed various studies including prospective cohorts, cross-sectional studies, longitudinal evaluations, genetic studies, and experimental models that investigated the role of vitamin D in autoimmune diseases. Results: There is evidence based on these various studies that several key autoimmune diseases are modulated by vitamin D. These diseases include, but are not limited to, multiple sclerosis (MS), scleroderma or systemic sclerosis (SSc), autoimmune thyroid diseases, rheumatoid arthritis (RA), and primary biliary cirrhosis (PBC). Conclusions: Although there is evidence for vitamin D as a factor in the pathophysiology of autoimmune diseases, the mechanism for this association has yet to be elucidated. Additional data are needed to corroborate these findings.
Bronchogenic carcinoma: utility of CT in the evaluation of patients with suspected lesions.

PURPOSE To assess the utility of computed tomography (CT) in the evaluation of suspected bronchogenic carcinoma. MATERIALS AND METHODS CT scans were reviewed of 362 patients who had undergone CT for suspected bronchogenic carcinoma. RESULTS CT findings of 275 patients were consistent with bronchogenic carcinoma. Sixty-five tumors were deemed unresectable on the basis of CT findings, 21 were deemed unresectable on the basis of CT findings and poor surgical risk, 26 proved to be benign, six were metastatic disease from an extrathoracic primary tumor, and 157 were potentially resectable bronchogenic carcinoma. Surgical mediastinal nodal sampling enabled documentation of metastases in 60 of 159 patients. According to nodal station, the sensitivity of CT for metastases was 67% for nodes measured in the long axis and 58% for nodes measured in the short axis; specificity was 56% and 86%, respectively. CONCLUSION CT can be used to confirm or exclude the presence of bronchogenic carcinoma and to obviate thoracotomy. The specificity of CT is limited, and a histologic diagnosis or follow-up evaluation is necessary. CT has limited value in staging mediastinal lymph nodes.