Miracle-dz/UniFAR-FTUs huggingface dataset:
Intraperitoneal recombinant gamma-interferon in patients with recurrent ascitic ovarian carcinoma: modulation of cytotoxicity and cytokine production in tumor-associated effectors and of major histocompatibility antigen expression on tumor cells.

Seven patients with advanced epithelial carcinoma and ascites, relapsing after two or more regimens of standard chemotherapy, have been treated with recombinant gamma-interferon (rIFN-gamma) i.p., via a permanent catheter. rIFN-gamma (Immuneron; Biogen; 0.5 mg = 10(7) IU in 2 liters of saline) was administered 3 times a week, on alternate weeks, for a total of nine courses. No major toxicities were observed: mild fever, malaise, and a flu-like syndrome occurred in all patients. The modulation of immunological parameters was studied. Cytotoxic activity of immunocompetent cells against tumor cell lines was measured both in the peritoneal compartment and in peripheral blood mononuclear cells. A significant increase of cytotoxicity of tumor-associated macrophages was observed in 5 of 7 patients and in 4 of 7 patients with tumor-associated peritoneal lymphocytes. Circulating effector cells were only occasionally stimulated. Tumor-associated macrophages isolated from the ascitic fluid and stimulated with lipopolysaccharide produced higher amounts of interleukin 1 in 5 of 6 patients tested, while interleukin 6 production by unstimulated tumor-associated macrophages was augmented in 2 of 2 patients after rIFN-gamma treatment. Freshly isolated ovarian carcinoma cells from the ascitic fluid has a variable, although usually low, expression of HLA-DR antigens. rIFN-gamma treatment caused a marked increase in HLA-DR expression in all patients tested. Expression of HLA class I antigens was negative in 2 of 5 patients and was strongly increased in 1 of the 2 after treatment. The observation that rIFN-gamma administered i.p. activates in situ effector cells and augments major histocompatibility antigen expression in tumor cells, with minimal toxicity, encourages further efforts to investigate its therapeutic potential in ovarian carcinoma.
Chainer : a Next-Generation Open Source Framework for Deep Learning

Software frameworks for neural networks play key roles in the development and application of deep learning methods. However, as new types of deep learning models are developed, existing frameworks designed for convolutional neural networks are becoming less useful. In this paper, we introduce Chainer, a Python-based, standalone open source framework for deep learning models. Chainer provides a ﬂexible, intuitive, and high performance means of implementing a full range of deep learning models, including state-of-the-art models such as recurrent neural networks and variational autoencoders.
Effects of agricultural runoff on native amphibians in the Lower Fraser River Valley, British Columbia, Canada

Hatching success, deformity rates, and survivorship of northern red‐legged frogs (Rana aurora) and northwestern salamanders (Ambystoma gracile) were assessed at three agricultural and three reference sites in the Sumas Prairie, British Columbia, Canada. In 1997 and 1998, eggs of both species and eggs of R. aurora, respectively, were placed in Nytex mesh cages (Irwindale, CA, USA) in roadside ditches at each site. Concurrently in 1997, eggs of R. aurora were reared in the laboratory but were exposed to water samples from each of the study sites. Hatching success was significantly lower at all agricultural sites compared to the reference sites for both species. However, no differences were observed in hatching success among sites for eggs of R. aurora reared in the laboratory. Water chemistry differed among all sites, but the largest differences were between reference and agricultural sites. Ammonia (maximum of 1.27 mg/L), total phosphate (maximum of 8.14 mg/L), and biological oxygen demand (maximum of 79.00 mg/L) were high at some of the agricultural sites during the development period. Results suggest that agricultural runoff may contribute to lower reproductive success and ultimately to reduced population viability of amphibian populations in the Lower Fraser Valley (BC, Canada).
Use of pulsed shortwave diathermy and joint mobilization to increase ankle range of motion in the presence of surgical implanted metal: A case series.

STUDY DESIGN Case series. BACKGROUND Traditionally, all forms of diathermy have been contraindicated over metal implants. There is a lack of research-based evidence for harm regarding the use of pulsed shortwave diathermy (PSWD) over orthopedic metal implants. Because PSWD is an effective modality for deep heating, we investigated whether ankle range of motion (ROM) could improve with the cautious use of PSWD and joint mobilizations, despite orthopedic metal implants being in the treatment field. CASE DESCRIPTIONS Four subjects presented with decreased ankle ROM due to extensive fractures from traumatic injuries. All subjects were postsurgical, with several internal fixation devices. Subjects previously received rehabilitation therapy involving joint mobilizations, therapeutic exercises, moist heat, and ice, but continued to lack 15 degrees to 23 degrees of ankle dorsiflexion. The Human Subjects Review Board of Brigham Young University approved the methods of this case series. Subjects gave written informed consent. Initial dorsiflexion active ROM for each patient was -3 degrees, 0 degrees, 8 degrees, and 5 degrees, respectively. Treatment regime consisted of PSWD to the ankle for 20 minutes at 27.12 MHz, 800 pps, 400 microseconds (48 W). Immediately after PSWD, mobilizations were administered to the joints of the ankle and foot. Ice was applied posttreatment. OUTCOMES Dorsiflexion improved 15 degrees, 15 degrees, 10 degrees, and 14 degrees, respectively, after 8 or 13 visits. All patients returned to normal activities with functional ROM in all planes. Follow-up 4 to 6 weeks later indicated that the subjects maintained 78% to 100% of their dorsiflexion. No discomfort, pain, or burning was reported during or after treatment. No negative effects were reported during the short-term follow-up. DISCUSSION When applied with appropriate caution, we propose PSWD (48 W) may be an appropriate adjunct to joint mobilizations to increase ROM in peripheral joints, despite implanted metal. We continue to advise caution when applying diathermy with machines other than the Megapulse II. Further research is needed to determine the safety parameters of other diathermy machines. As a final caution, we advise that diathermy not be used in the presence of a cardiac pacemaker or neurostimulator.
The Effect of Education on Age-Related Changes in Three Cognitive Domains: A Cross-Sectional Study in Primary Care

The present study aims to investigate the protective effect of formal education on age-related changes in different cognitive domains with the hypothesis that it may attenuate the rate of decline. Individuals aged 50 years or older attending primary care physicians without known brain disease (431 participants, mostly [60.3%] female with 66.3 [±9.1] years of age and 7.7 [±4.1] years of education, on average), were evaluated with a neuropsychological battery including 28 cognitive measures. Cognitive domains identified by factor analysis were subject to repeated multiple regression analyses to determine the variance explained by age and education controlling for gender, depressive symptoms, and vascular risk factors. The slope of the regression equation was compared between two educational groups with an average of 4 years and 11 years of education, respectively. Factors identified corresponded to processing ability (Factor 1), memory (Factor 2), and acquired knowledge (Factor 3). Although education improved performance in Factors 1 and 3, it did not change the slope of age-related decline in any factor. This study suggests that in culturally heterogeneous groups, small increments in education enhance cognition but do not modify the rate of decline of executive functioning with age. These results contradict some clinical findings and need to be confirmed in longitudinal studies.
Carbachol-induced synchronized rhythmic bursts in CA3 neurons of guinea pig hippocampus in vitro.

1. Carbachol effects on CA3 hippocampal cells were studied in the absence of ionotropic glutamatergic and GABAergic transmission with intracellular and extracellular recordings from guinea pig septohippocampal slices. 2. In all experiments the perfusing solution contained ionotropic glutamate and gamma-aminobutyric acid (GABA) receptor blockers [6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, 10-20 microM), 3-((+/-)-2-carboxypiperazin-4-il)propyl-1-phosphonic acid (CPP, 10-20 microM), and picrotoxin (50 microM), respectively]. Under these conditions, the excitatory and early inhibitory postsynaptic potentials, evoked in CA3 pyramidal cells by mossy fiber stimulation before the addition of the blockers, were completely suppressed. 3. Carbachol (50 microM) introduced via bath perfusion or pulse application elicited a series of rhythmic bursts with overriding action potentials. Each rhythmic burst lasted up to 30 s and repeated at intervals of 0.7-6 min. Rhythmic bursts were blocked by atropine (1 microM). 4. At membrane potentials more depolarized than -70 mV, carbachol also elicited a sustained depolarization associated with an increase in membrane input resistance and action-potential firing. This response was blocked by atropine (1 microM). 5. Carbachol can induce both rhythmic bursts and sustained depolarizations in the same cell. Rhythmic bursts were elicited when the membrane potential of the cell was more hyperpolarized than -70 mV; sustained depolarizing responses were activated by carbachol when the cell membrane potential was more depolarized than -70 mV. 6. Extracellular field potential responses in the CA3 region occurred simultaneously with rhythmic bursts, indicating the synchronization of the event in the CA3 field. Dual intracellular recordings confirmed that rhythmic bursts occurred simultaneously in CA3 hippocampal pyramidal cells. (ABSTRACT TRUNCATED AT 250 WORDS)
Hypoxia and Placental Development

Hemochorial placentation is orchestrated through highly regulated temporal and spatial decisions governing the fate of trophoblast stem/progenitor cells. Trophoblast cell acquisition of specializations facilitating invasion and uterine spiral artery remodeling is a labile process, sensitive to the environment, and represents a process that is vulnerable to dysmorphogenesis in pathologic states. Hypoxia is a signal guiding placental development, and molecular mechanisms directing cellular adaptations to low oxygen tension are integral to trophoblast cell differentiation and placentation. Hypoxia can also be used as an experimental tool to investigate regulatory processes controlling hemochorial placentation. These developmental processes are conserved in mouse, rat, and human placentation. Consequently, elements of these developmental events can be modeled and hypotheses tested in trophoblast stem cells and in genetically manipulated rodents. Hypoxia is also a consequence of a failed placenta, yielding pathologies that can adversely affect maternal adjustments to pregnancy, fetal health, and susceptibility to adult disease. The capacity of the placenta for adaptation to environmental challenges highlights the importance of its plasticity in safeguarding a healthy pregnancy. Birth Defects Research 109:1309–1329, 2017. © 2017 Wiley Periodicals, Inc.
Effects of Propranolol on Azygos Venous Blood Flow and Hepatic and Systemic Hemodynamics in Cirrhosis

The effects of propranolol on blood flow through gastroesophageal collaterals and on systemic and hepatic hemodynamies were investigated in 23 cirrhotic patients with portal hypertension. Gastroesophageal collateral blood flow was evaluated by the measurement of azygos venous blood flow by continuous thermal dilution. Azygos venous blood flow was markedly increased in these patients (544 ± 48 ml per min, as compared with 132 ± 18 ml per min in subjects without portal hypertension (p < 0.001).
Factors associated with re-presentation to emergency departments in elderly people with pain.

OBJECTIVES To identify medical, social and demographic factors associated with increased risk of 30-day re-presentation to the emergency department (ED) in elderly people presenting with pain. METHODS We undertook a single site, prospective observational study of all patients aged >65 years discharged from the ED with pain. Data were collected on possible medical, social and demographic predictors of ED readmission. Participants were a subset of all elderly patients presenting to the ED with pain, and received follow-up case management as part of the hospital's rapid response, assessment and care planning program for elderly people. RESULTS Over 8 months, 356 people were eligible for inclusion in the study; of these, 189 consented to case management and to participate in the study. Three factors statistically increased odds of re-presentation to ED within 30 days: (1) prescription of opioids (P=0.003); (2) the presence of Home and Community Care Services (P=0.03); and (3) the absence of a gait aid (P=0.019). Nineteen per cent of eligible patients re-presented to ED within 30 days of initial presentation. CONCLUSION These findings contribute to current debate about opioid prescription and effective pain management in the elderly. The study highlights the need for routine follow-up care of older people discharged from the ED with pain, particularly those discharged home with opioids or with complex care needs.
Dynamic Planning of Facility Locations with Benefits from Multitype Facility Colocation

This article presents a mixed‐integer programming model for a multitype facility colocation problem with capacity expansion over a multiperiod horizon. This problem is motivated by the emerging U.S. biofuel industry that is rapidly expanding its infrastructure facilities to produce bioethanol from agricultural crops. Each type of facility (e.g., corn‐ or cellulose‐based biorefinery) requires a different type of raw material (e.g., corn or perennial grass), but they produce the same final product (e.g., bioethanol), and colocation of multiple types of facilities results in cost‐saving benefits due to complementary production process and byproduct recycling. Multiple solution approaches (i.e., Lagrangian relaxation, Benders decomposition, and accelerated Benders decomposition) are proposed to solve this problem. Numerical experiments show that accelerated Benders decomposition most effectively solves large‐sized problems in a short amount of time. Various managerial insights are also drawn from the computational results.
The Cognitive Style of PowerPoint : A Case Study

One of the most frequently used communication presentation tools is PowerPoint. This tool is widely utilized on all levels in businesses. Students receive lectures made with PowerPoint, and also learn how to use it themselves during their studies. PowerPoint has become a standard tool for presentations and has been criticized by some scientists, such as Tufte (2006). He wrote an essay on this subject called “The Cognitive Style of PowerPoint” [10]. This essay can also be found in his book “Beautiful Evidence” [11], this book contains several articles and essays on evidence presentation. This research will focus on exploring the problems Tufte (2006) describes for using PowerPoint as a business and technical communications tool according. There will also be a comparative case study on the extent of which two IT Consultancy companies actually encounter the problems described by Tufte (2006) on the use of PowerPoint as a business and communications tool.
Effects of pregnanolone and dehydroepiandrosterone on ethanol intake in rats administered ethanol or saline during adolescence.

BACKGROUND Adolescent alcohol use may contribute to long-term changes in the receptors and neuroactive steroids that may mediate its effects and to subsequent alcohol abuse and dependence as an adult. Therefore, in this study, ethanol preference and intake as an adult were examined after adolescent ethanol or saline administration. In addition, ethanol intake in the same groups was examined after administration of 2 neuroactive steroids with modulatory effects at GABA(A) receptors. METHODS Two groups of male Long-Evans rats were administered 15 intraperitoneal (i.p.) injections of either ethanol (2 g/kg, 20% v/v) or saline between postnatal days 35 and 63. Starting on postnatal day 75, both groups were trained to consume 10% ethanol using a saccharin-fading procedure, and ethanol intake and preference were measured after a series of manipulations involving food deprivation, changes in the duration of access to ethanol, and changes in the concentrations of ethanol presented. Following these manipulations, pregnanolone (1 to 10 mg/kg) and dehydroepiandrosterone (DHEA, 1 to 100 mg/kg) were administered prior to preference sessions with an 18% ethanol solution. RESULTS Adult ethanol preference and intake did not differ significantly in subjects treated with either saline or ethanol as adolescents during training, the substitution of other ethanol concentrations (3.2 to 32%), ad-lib feeding, or moderate food deprivation. Pregnanolone administration altered the intake of both adolescent-treated groups after the first injection of 3.2 mg/kg and after repeated injections with 10 mg/kg, a dose that produced sedation. In contrast, multiple doses of DHEA consistently decreased intake of an 18% ethanol concentration in both groups after repeated injections and 3 doses of DHEA (10, 32, and 56 mg/kg) administered with various ethanol concentrations dose-dependently shifted the ethanol-concentration curves for the volume and dosage of ethanol consumed downward. CONCLUSIONS These results indicate that chronic intermittent ethanol (CIE) administration of 2 g/kg during adolescence did not alter preference or overall consumption of ethanol in outbred rats trained to drink ethanol as an adult under the conditions tested, and that DHEA may be more effective than pregnanolone at significantly decreasing ethanol consumption.
Effects of chicory inulin on ruminal fermentation in vitro

Summary: The objective of this study was to investigate the effects of spray dried inulin powder from chicory roots of different origins on in vitro ruminal fermentation. For this purpose, two long-term experiments were made with the Rumen Simulation Technique (Rusitec), in which the fermentation of a mixed ration of hay (5 g/d) and concentrate (4 g/d) was compared with the fermentation of the same diet in the presence of chicory inulin. The Rusitec system consisted of nine vessels (fermenters): three of them received daily 1.5 g of inulin powder from the Netherlands, three vessels received daily 1.5 g of inulin powder from Denmark and three vessels received no additives (control) in experiment I. This experimental setup was repeated in experiment II. However, 1.5 g of inulin from China and 1.5 g inulin from Germany were tested. Compared to control vessels, ruminal pH was significantly lower in the vessels supplemented with Chinese and German inulin. Dutch and Danish inulin had no effect on ruminal pH. Danish and Chinese inulin resulted in an increase of total-SCFA (short-chain fatty acids), acetate, propionate, butyrate, isovalerate and valerate production whereas Dutch inulin led to an increase in butyrate, iso-valerate and valerate production only. Addition of German inulin caused a significant increase in the production of total-SCFA, acetate, butyrate, iso-valerate and valerate in the rumen fluid. Compared to control, all inulin preparations decreased NH3-N concentrations in the fermentation vessels. The digestibility of organic matter was not statistically influenced by Chinese and German inulin. However, Dutch and Danisch inulin decreased significantly the digestibility of organic matter compared to control vessels. These results indicated that, in relation to its origin, inulin stimulated ruminal fermentation and it was especially effective at decreasing ruminal ammonia concentration in vitro.
Foreign Bodies in Sarcoidosis

Sarcoidosis is a multisystem disease of unknown etiology. The demonstration of polarizable foreign bodies in cutaneous granulomas is generally thought to exclude a diagnosis of sarcoidosis. Nevertheless, some investigators have reported systemic sarcoidosis with cutaneous manifestations in which polarizable particles were associated with granuloma formation in the skin. We searched the biopsy specimens of granulomatous lesions from 50 patients with cutaneous sarcoidosis using polarization microscopy to estimate the frequency of polarizable foreign bodies in cutaneous lesions of sarcoidosis. Using electron probe microanalysis, we sought to determine what elements compose these foreign bodies. Polarizable foreign bodies were found in the granulomatous skin lesions of 12 of 50 patients with cutaneous sarcoidosis. All 12 patients also had at least one other granulomatous systemic lesion, and 4 had biopsy specimens of a systemic lesion available for review. Polarizable foreign bodies were found in two cases. The elements identified were calcium, phosphorus, silicon, and aluminum. Polarizable foreign bodies were found in cutaneous sarcoidosis far more often than expected. Foreign bodies were also found in granulomatous systemic lesions. The foreign body may serve as an inciting stimulus for granuloma formation in selected cases of sarcoidosis.
A Systematic Review of the Use of Rituximab for Desensitization in Renal Transplantation

Background Rituximab is a B lymphocyte–depleting agent used to treat lymphoma and autoimmune diseases. Recently, it has been used for desensitization therapy in ABO-incompatible and highly sensitized recipients undergoing renal transplantation. Methods A systematic review was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Four databases and three trial registries were searched for studies comparing rituximab with non-rituximab desensitization protocols. A lack of randomized evidence precluded meta-analysis, and thus a narrative review was conducted. Results Forty-five records met the inclusion criteria, relating to 21 individual studies (two randomized controlled trials and 19 retrospective cohort studies). Ten studies investigated the use of rituximab in ABO-incompatible patients; most found no significant differences in patient and graft outcomes when compared most frequently to splenectomy-based protocols. Nine studies of limited quality focused on highly sensitized recipients (positive cross-match, donor-specific antibody, and elevated panel reactive antibody) and demonstrated some benefits in graft survival, acute and chronic rejection, and sensitization levels with rituximab. The remaining two studies combined ABO-incompatible and highly sensitized recipients and found no statistically significant increase in infectious complications with rituximab. Conclusion Evidence of limited quality was identified to support the use of rituximab desensitization in highly sensitized recipients. Among ABO-incompatible recipients, rituximab was found to be equivalent to splenectomy, indicating that this invasive surgical procedure is not necessary. Further randomized controlled trials are required to better define the efficacy, long-term safety, and optimal dosing regimen of rituximab in this setting.
Mode of Cell Wall Growth of Bacillus megaterium

The growth of the cell wall of Bacillus megaterium KM was examined by labeling the cell wall uniformly with 3H-α, ε-diaminopimelic acid and examining by radioautography the distribution of labeled cell wall material in daughter cells. The results indicate that the label is distributed uniformly to all daughter cells and rule out a single growth point, either central or apical, for these cells. The results strongly suggest that cell wall growth occurs by uniform deposition of new wall over the whole cell surface.