Miracle-dz/UniFAR-FTUs huggingface dataset:
Female boxing in Italy: 2002–2007 report

Objective To collect medical data on women's boxing. Design Cross-sectional and longitudinal study. Setting Medical examinations requested by Italian laws. Participants A retrospective study was conducted on all female boxing competitions in Italy from April 2001 to December 2007. Sixty-one amateur female boxers were evaluated longitudinally. Interventions (1) Retrospective study: All pre-/postmatch medical reports were analysed. (2) Prospective study: Breast, gynaecologic, brain, eyes, ear, nose and throat examinations were carried out. Main outcome measurements (1) Retrospective study: Any injury assessed before/after the match. (2) Prospective study: Health problems which could be related to boxing activity. Results (1) Retrospective study: Data from 5600 examinations were collected. Precompetition, a medical problem was recorded in three athletes (one conjunctiva hyperemia, one zygomatic bruise, one eyelid haematoma). Post competition, 51/2800 medical checks showed mild common injuries, such as soft tissue facial lesions, epistaxis and hand-wrist problems. Only one concussion was recorded with hospitalisation (for a thorough evaluation). Another athlete was hospitalised for a nasal fracture. (2) Prospective study: Two fibroadenomas, three ovarian cysts and one intramural uterine myoma were diagnosed. In four boxers, non-specific electroencephalographic abnormalities were detected, however, with a normal brain MRI in three (the fourth is still waiting for the radiologic procedure). Nasal septum deviation was common (42.6%) and a transmissive hypoacusia was observed in two athletes. No major eye injuries were reported. Conclusions Female boxing seems to be a safe sport with a very low incidence of events requiring hospitalisation. No specific diseases in female boxers could be observed, in particular regarding the breast and reproductive system.
Anaemia characterises patients with myelofibrosis harbouring MplW515L/K mutation

The clinical and haematological phenotype of patients with myelofibrosis harbouring MPLW515L/K mutation has not been thoroughly investigated. Of 217 myelofibrosis subjects, 18 (8·2%) had an MPL mutation, four of which (22%) co‐existed with JAK2V617F mutation. When compared with MPL wild‐type patients, irrespective of JAK2V617F status, those with MPLW515L/K, were more frequently female, were older (61 years vs. 57 years; P = 0·02), presented with more severe anaemia (haemoglobin, 101 g/l vs. 121 g/l; P = 0·002) and were more likely to require regular transfusional support (P = 0·012). These data indicate that MPL mutation in myelofibrosis characterises patients with more severe anaemic phenotype.
Cognition and performance: anxiety, mood and perceived exertion among Ironman triathletes

Objective The authors examined the changing patterns of mood before and after an Ironman triathlon, and the relationships between expected performance outcomes, perception of effort and pacing. Design Twelve participants in the 2008 Ironman Austria triathlon competition were studied before, during and after the event. Each participant completed measures of mood, anxiety and perceived exertion, while pacing was calculated from official race timings at various points on the course. Results Positive correlations were found between distance covered and rating of perceived exertion (RPE) during each of the individual disciplines, and also between RPE and the percentage of overall race time completed (r=0.826, p<0.001). A negative correlation was found between average speed and distance covered during the run segment (r=−0.911, p<0.005) with pace gradually declining. Differences occurred in the profile of mood states mood subscales of tension and fatigue between the baseline, prerace and postrace trials. Somatic anxiety was higher before the race compared with baseline measures. Discussion RPE followed a linear progression of RPE during each discipline followed by a re-setting of the perception of effort at the start of the next discipline. The increase in RPE for the entire event followed a linear increase. The linear decline in run pace is consistent with a recent model in which expected RPE is used to modulate pacing. Anxiety and mood responses of participants in this study indicate that the emotional response of athletes before and after ultra-endurance exercise is closely aligned with their conscious thoughts.
Risk of injury on third-generation artificial turf in Norwegian professional football

Background Artificial turf is used extensively in both recreational and elite football in areas with difficult climatic conditions. Objective To compare the risk for acute injuries between natural grass (NG) and third-generation artificial turf (3GAT) in male professional football. Study design Prospective cohort study. Methods All injuries sustained by players with a first-team contract were recorded by the medical staff of each club, from the 2004 throughout the 2007 season. An injury was registered if the player was unable to take fully part in football activity or match play. Results A total of 668 match injuries, 526 on grass and 142 on artificial turf, were recorded. The overall acute match injury incidence was 17.1 (95% CI 15.8 to 18.4) per 1000 match hours; 17.0 (95% CI 15.6 to 18.5) on grass and 17.6 (95% CI 14.7 to 20.5) on artificial turf. Correspondingly, the incidence for training injuries was 1.8 (95% CI 1.6 to 2.0); 1.8 (95% CI 1.5 to 2.0) on grass and 1.9 (95% CI 1.5 to 2.2) on artificial turf respectively. No significant difference was observed in injury location, type or severity between turf types. Conclusion No significant differences were detected in injury rate or pattern between 3GAT and NG in Norwegian male professional football.
Phase I/II study of vemurafenib in patients with unresectable or recurrent melanoma with BRAFV600 mutations

We investigated the efficacy and safety of vemurafenib in Japanese patients with unresectable or recurrent melanoma with BRAFV600 mutations. This was a two‐step open‐label multicenter phase I/II study. Step 1 evaluated the initial safety of vemurafenib 960 mg administrated p.o. twice daily in three patients. In step 2, eight patients received vemurafenib 960 mg administrated p.o. twice daily for 28‐day treatment cycles; the primary outcome measure was response rate, as determined by independent review committee using Response Evaluation Criteria in Solid Tumors version 1.1. Adverse events (AE) experienced by five or more patients were arthralgia (n = 10), myalgia (n = 8), alopecia (n = 7), and rash, maculopapular rash and decreased appetite (n = 5 each). Three patients had grade 3 AE. One serious AE occurred in one patient (abnormal hepatic function). Six patients required dose reduction because of AE. One patient died within 28 days after the last dose, but death was caused by disease progression and not associated with the study drug. In the eight patients in step 2, overall response rate was 75.0%, none had a complete response and six had a partial response (75.0%). Median response duration was 240.0 days, disease control rate 87.5%, median progression‐free survival 416.0 days and median overall survival 443.0 days. In conclusion, vemurafenib treatment resulted in an overall response rate of 75% in Japanese patients with metastatic melanoma with BRAFV600 mutations. All toxicities were manageable.
Head-to-head comparison between echocardiography and cardiac MRI in the evaluation of the athlete's heart

Objective Echocardiographic cut-off values are often used for cardiac MRI in athletic persons. This study investigates the difference between echocardiographic and cardiac MRI measurements of ventricular and atrial dimensions and ventricular wall thickness, and its effect on volume and wall mass prediction in athletic subjects compared with non-athletic controls. Methods Healthy non-athletic (59), regular athletic (59) and elite athletic (63) persons, aged 18–39 years and training 2.5±1.9, 13.0±3.0 and 25.0±5.4 h/week, respectively (p<0.001), underwent echocardiography and cardiac MRI consecutively. Left ventricular (LV) and right ventricular (RV) dimensions were measured on both modalities. LV and RV end-diastolic and end-systolic volumes and LV wall mass were determined on cardiac MRI. Echocardiographic M-mode LV volumes (Teichholz formula) and LV wall mass (American Society of Echocardiography formula) were calculated. Results LV and RV dimensions were smaller on echocardiography (p<0.001), and although the correlation with the cardiac MRI volume was good (p<0.01), the difference in volume was large (LV end-diastolic volume difference 93±32 g, p<0.001). LV wall thickness and calculated wall mass were significantly (p<0.001) larger on echocardiography (wall mass difference −101±34 g, p<0.001). Differences in absolute dimensions did not change significantly between non-athletic and athletic persons; however, the difference in echocardiographic estimations of LV volumes and wall mass did increase significantly with the larger athlete's heart, requiring possible correction of the standard echocardiographic formulas. Conclusions Echocardiography shows systematically smaller atrial and ventricular dimensions and volumes, and larger wall thickness and mass, compared with cardiac MRI. Correction for the echocardiographic formulas can facilitate better intertechnique comparability. These findings should be taken into account in the interpretation of cardiac MRI findings in athletic subjects in whom cardiomyopathy is suspected on echocardiography.
The additional effect of orthotic devices on exercise therapy for patients with patellofemoral pain syndrome: a systematic review

The aim of the study is to determine “the additional effect of. function” for patellofemoral pain syndrom (PFPS). The additional effect of orthotic devices over exercise therapy on pain and function. A systematic literature search was conducted in MEDLINE, CINAHL, EMBASE, Cochrane and PEDro. Randomised controlled trials and controlled clinical trials of patients diagnosed with PFPS evaluating a clinically relevant outcome were included. Treatment had to include exercise therapy combined with orthotics, compared with an identical exercise programme with or without sham orthotics. Data were summarised using a best evidence synthesis. Eight trials fulfilled the inclusion criteria, of which three had a low risk of bias. There is moderate evidence for no additive effectiveness of knee braces to exercise therapy on pain (effect sizes (ES) varied from −0.14 to 0.04) and conflicting evidence on function (ES −0.33). There is moderate evidence for no difference between knee braces and exercise therapy versus placebo knee braces and exercise therapy on pain and function (ES −0.1–0.10). More studies of high methodological quality are needed to draw definitive conclusions.
Vascular endothelial growth factor inhibition is not an effective therapeutic strategy for relapsed or refractory multiple myeloma: a phase 2 study of pazopanib (GW786034).

To the editor: Vascular endothelial growth factor (VEGF) stimulates plasma cell proliferation and migration in vitro, and preclinical studies have demonstrated that these effects can be blocked by inhibition of VEGF receptors (VEGFRs) in multiple myeloma (MM) cell lines. [1][1] Pazopanib (GW786034
Creativity and Madness: New Findings and Old Stereotypes

Albert Rothenberg has devoted the major part of a distinguished psychiatric career to a broad program of research on creativity. In this excellent, concise volume, he reports his current views on this fascinating subject. The book is by no means confined to the limited topic implied by its title; it addresses itself to the effects on creative endeavors of a variety of adaptive disturbances and also deals with nonpathological aspects. Creativity and Madness is written for a nonspecialist readership; most of its chapters were previously published in journals for the laity and do not include the apparatus of comprehensive scholarly references or even the full research data on which Rothenberg's conclusions are based. Although it is, as a consequence, a very personal statement of the author's views in a field still lacking wide consensus, it is well argued and judicious and, therefore, a useful introduction to the domain of creativity
Perceptual cues in the regulation of exercise performance – physical sensations of exercise and awareness of effort interact as separate cues

It has been argued that the physical sensations induced by exercise, measured as the ratings of perceived exertion (RPE), are distinct from the sense of effort. This study aimed to determine whether a new measure of task effort – the Task Effort and Awareness (TEA) score – is able to measure sensations distinct from those included in the conventional RPE scale. Seven well-trained cyclists completed a maximal effort 100 km time trial (TT) and a submaximal trial at 70% of the power sustained during the TT (70% TT). Five maximal 1 km sprints were included in both trials. Both the RPE related solely to physical sensation (P-RPE) and the TEA score increased during the TT and were linearly related. During the 70% TT, both P-RPE and TEA scores increased, but TEA increased significantly less than P-RPE (p<0.001). TEA scores reached maximal values in all 1 km sprints in both the maximal TT and 70% TT, whereas the RPE increased progressively, reaching a maximal value only in the final 1 km sprints in both the TT and the 70% TT. These results indicate that the physical sensations of effort measured as the P-RPE act as the template regulating performance during exercise and that deviation from that template produces an increase in the sense of effort measured by the TEA score. Together, these controls ensure that the chosen exercise intensity does not threaten bodily homeostasis. Our findings also explain why submaximal exercise conducted within the constraints of the template P-RPE does not produce any conscious awareness of effort.
Incidence of midportion Achilles tendinopathy in the general population

Background Achilles tendon disorders, like Achilles tendinopathy, are very common among athletes. In the general population, however, knowledge about the incidence of Achilles tendinopathy is lacking. Design Cross-sectional study. Methods In a cohort of 57.725 persons registered in primary care, the number of patients visiting the general practitioner (GP) with diagnosis of mid-portion Achilles tendon problems was counted using computerised registration networks of GPs in 2009. Subsequently, the authors assessed associations of these rates with demographic characteristics. Results The incidence rate of Achilles tendinopathy is 1.85 per 1,000 Dutch GP registered patients. In the adult population (21–60 years), the incidence rate is 2.35 per 1,000. In 35% of the cases, a relationship with sports activity was recorded. Conclusion This is the first report on incidence rates of mid-portion Achilles tendinopathy in general practice. With an incidence of 1.85 per 1,000 registered persons, Achilles tendinopathy is frequently seen by GPs. The actual incidence might even be higher due to study limitations. More research on the frequency of this injury is required.
SEMINARS IN RESPIRATORY MEDICINE—VOLUME 14, NUMBER 2, MARCH 1993 Pulmonary Response to Exercise in Health and Disease

During the rising metabolic demands of exercise, an increase in delivery of oxygen and removal of excess carbon dioxide are required for the skeletal muscles to perform effectively. The pulmonary system, together with the cardiovascular, peripheral vascular, neurologic, and hematologic systems, must be able to meet these two demands for efficient exercise to occur. The pulmonary system works as a single cog in this complex physiologic design, as depicted in Figure 1. Its role is to transfer oxygen into the blood at a rate equal to its utilization in the mitochondrial electron transport system, and to clear carbon dioxide from the body at a rate that maintains acid-base balance. , 3 The metabolic demands of the muscles during exercise are met by specific ventilatory, gas exchange, and pulmonary circulatory responses. The purpose of this article is to characterize each of these three functions of the respiratory system in healthy individuals and demonstrate the responses to exercise in patients with chronic airflow limitation. Defining a "normal" response is a difficult task and is dependent on the population studied. "Normal" subjects range from athletes to healthy sedentary people. With exercise, an athlete will perform differently from a sedentary individual, yet responses of both should be interpreted as normal. An individual's exercise tolerance can also change and improve over time. In addition, alterations in performance are rarely secondary to a disorder in a single mechanism. Therefore when interpreting a subject's physiologic limitations during exercise, it is important not to dwell on the specific numerical values, but rather the general patterns and trends of the responses. NORMAL PATTERN OF VENTILATION DURING EXERCISE
Can a single question provide an accurate measure of physical activity?

Objective The ‘single-item measure’ was developed as a short self-report tool for assessing physical activity. The aim of this study was to test the criterion validity of the single-item measure against accelerometry. Design Participants (n=66, 65% female, age: 39±11 years) wore an accelerometer (ActiGraph GT3X) over a 7-day period and on day 8, completed the single-item measure. The number of days of ≥30 min of accelerometer-determined moderate to vigorous intensity physical activity (MVPA) were calculated using two approaches; first by including all minutes of MVPA and second by including only MVPA accumulated in bouts of ≥10 min (counts/min ≥1952). Associations between the single-item measure and accelerometer were examined using Spearman correlations and 95% limits of agreement. Percent agreement and κ statistic were used to assess agreement between the tools in classifying participants as sufficiently/insufficiently active. Results Correlations between the number of days of ≥30 min MVPA recorded by the single-item and accelerometer ranged from 0.46 to 0.57. Participants underreported their activity on the single-item measure (−1.59 days) when compared with all objectively measured MVPA, but stronger congruence was observed when compared with MVPA accumulated in bouts of ≥10 min (0.38 days). Overall agreement between the single-item and accelerometry in classifying participants as sufficiently/insufficiently active was 58% (k=0.23, 95% CI 0.05 to 0.41) when including all MVPA and 76% (k=0.39, 95% CI 0.14 to 0.64) when including activity undertaken in bouts of ≥10 min. Conclusions The single-item measure is a valid screening tool to determine whether respondents are sufficiently active to benefit their health.
The effects of a congested fixture period on physical performance, technical activity and injury rate during matches in a professional soccer team

Background In modern professional soccer, the ability to recover from official match-play and intense training is often considered a determining factor in subsequent performance. Objective To investigate the influence of playing multiple games with a short recovery time between matches on physical activity, technical performance and injury rates. Methods The variation of physical (overall distance, light-intensity, low-intensity, moderate-intensity and high-intensity running) and technical performance (successful passes, balls lost, number of touches per possession and duels won) of 16 international players was examined during three different congested periods of matches (six games in 18 days) from the French League and Cup (n=12), and the UEFA Champions’ League (n=6) during the 2011–2012 season and compared with that reported in matches outside these periods. Data were collected using a computerised match analysis system (Amisco). Injury rate, time loss injuries, as well as the mechanism, circumstances and severity of the injury were also analysed. Results No differences were found across the six successive games in the congested period, and between no congested and the three congested periods for all the physical and technical activities. The total incidence of injury (matches and training) across the prolonged congested periods did not differ significantly to that reported in the non-congested periods. However, the injury rate during match-play was significantly higher during the congested period compared with the non-congested period (p<0.001). The injury rate during training time was significantly lower during the congested period compared with the non-congested periods (p<0.001). The mean lay-off duration for injuries was shorter during the congested periods compared with the non-congested periods (9.5±8.8 days vs 17.5±29.6 days, respectively p=0.012, effect sizes=0.5). Conclusions Although physical activity, technical performance and injury incidence were unaffected during a prolonged period of fixture congestion, injury rates during training and match-play and the lay-off duration were different to that reported in matches outside this period.
Sport injuries and illnesses during the first Winter Youth Olympic Games 2012 in Innsbruck, Austria

Background Data on the injury and illness risk among young elite athletes are of utmost importance, because injuries and illnesses can counter the beneficial effects of sports participation at a young age, if children or adolescents are unable to continue to participate because of residual effects of injury or chronic illness. Objective To analyse the frequencies and characteristics of injuries and illnesses during the 2012 Innsbruck Winter Youth Olympic Games (IYOG). Methods We employed the International Olympic Committee (IOC) injury surveillance system for multisport events, which was updated for the Winter Olympic Games in Vancouver 2010. All National Olympic Committees (NOCs) were asked to report the daily occurrence (or non-occurrence) of newly sustained injuries and illnesses on a standardised reporting form. In addition, information on athletes treated for injuries and illnesses by the Local Organizing Committee medical services was retrieved from the medical centre at the Youth Olympic Village and from the University hospital in Innsbruck. Results Among the 1021 registered athletes (45% women, 55% men) from 69 NOCs, a total of 111 injuries and 86 illnesses, during the IYOG, were reported, resulting in an incidence of 108.7 injuries and 84.2 illnesses per 1000 registered athletes, respectively. Injury frequency was highest in skiing in the halfpipe (44%) and snowboarding (halfpipe and slope style: 35%), followed by ski cross (17%), ice hockey (15%), alpine skiing (14%) and figure skating (12%), taking into account the respective number of participating athletes. Knee, pelvis, head, lower back and shoulders were the most common injury locations. About 60% of injuries occurred in competition and about 40% in training, respectively. In total, 32% of the injuries resulted in an absence from training or competition. With regard to illnesses, 11% of women and 6% of men suffered from an illness (RR=1.84 (95% CI 1.21 to 2.78), p=0.003). The respiratory system was affected most often (61%). Conclusions Eleven per cent of the athletes suffered from an injury and 9% from illnesses, during the IYOG. The presented data constitute the basis for future analyses of injury mechanisms and associated risk factors in Olympic Winter sports, which, in turn, will be essential to develop and implement effective preventive strategies for young elite winter-sport athletes.