Miracle-dz/UniFAR-FTUs huggingface dataset:
Die Lage der Weltwirtschaft und der deutschen Wirtschaft im Herbst 2004

Am 19. Oktober 2004 stellten die sechs Wirtschaftsforschungsinstitute in Berlin ihr Herbstgutachten der Presse vor. Sie kamen zu der Ansicht, dass der Aufschwung in der Weltwirtschaft zwar anhalt, allerdings seit dem Fruhjahr 2004 etwas an Fahrt verliert. Die Abschwachung erklart sich zum Teil aus einer Straffung der bisher sehr expansiven Wirtschaftspolitik. Zwar blieben die monetaren Rahmenbedingungen zumeist ausgesprochen gunstig, aber in den USA liefen finanzpolitische Impulse aus, und in China wurden administrative Masnahmen ergriffen, um die uberschaumende Konjunktur zu zugeln. Die wirtschaftliche Aktivitat wurde zusatzlich von dem starken Anstieg der Roholpreise gedampft, die bis in den Oktober immer neue Rekordhohen erreichten. Der olpreisbedingte Kaufkraftentzug bremste insbesondere den privaten Konsum. Die Unternehmensinvestitionen, die - unterstutzt von der sehr expansiven Geldpolitik im vergangenen Jahr - mehr und mehr Dynamik entfaltet hatten, wurden hingegen weiter zugig ausgedehnt.
An EEMD Aided Comparison of Time Histories and Its Application in Vehicle Safety

In the context of signal processing, the comparison of time histories is required for different purposes, especially for the model validation of vehicle safety. Most of the existing metrics focus on the mathematical value only. Therefore, they suffer the measuring errors, disturbance, and uncertainties and can hardly achieve a stable result with a clear physical interpretation. This paper proposes a novel scheme of time histories comparison to be used in vehicle safety analysis. More specifically, each signal for comparison is decomposed into a trend signal and several intrinsic mode functions (IMFs) by ensemble empirical mode decomposition. The trend signals reflect the general variation and are free from the influence of high-frequency disturbances. With the help of dynamic time warping, the errors of time and magnitude between trends are calculated. The IMFs, which contain high-frequency information, are compared on frequency, magnitude, and local features. To illustrate the full scope and effectiveness of the proposed scheme, this paper provides three vehicle crash cases.
Regulation of Bcl-xL–ATP Synthase Interaction by Mitochondrial Cyclin B1–Cyclin-Dependent Kinase-1 Determines Neuronal Survival

The survival of postmitotic neurons needs continuous degradation of cyclin B1, a mitotic protein accumulated aberrantly in the damaged brain areas of Alzheimer's disease and stroked patients. Degradation of cyclin B1 takes place in the proteasome after ubiquitylation by the anaphase-promoting complex/cyclosome (APC/C)–cadherin 1 (Cdh1), an E3 ubiquitin ligase that is highly active in neurons. However, during excitotoxic damage—a hallmark of neurological disorders—APC/C–Cdh1 is inactivated, causing cyclin B1 stabilization and neuronal death through an unknown mechanism. Here, we show that an excitotoxic stimulus in rat cortical neurons in primary culture promotes cyclin B1 accumulation in the mitochondria, in which it binds to, and activates, cyclin-dependent kinase-1 (Cdk1). The cyclin B1–Cdk1 complex in the mitochondria phosphorylates the anti-apoptotic protein B-cell lymphoma extra-large (Bcl-xL), leading to its dissociation from the β subunit of F1Fo–ATP synthase. The subsequent inhibition of ATP synthase activity causes complex I oxidative damage, mitochondrial inner membrane depolarization, and apoptotic neuronal death. These results unveil a previously unrecognized role for mitochondrial cyclin B1 in the oxidative damage associated with neurological disorders.
THE EFFECT OF ICE ON INTRA-ARTICULAR TEMPERATURE IN THE KNEE OF THE DOG

The effect of surface cooling on intra-articular temperature was examined in dogs' knees. Four treatment protocols were examined: local ice compress application for 5, 15 and 30 min and local ice bath immersion for 15 min. Intraarticular temperatures were recorded using a needle microprobe inserted into the knee and continuous temperature recordings were made before, during and after the treatment. Rectal temperatures were also simultaneously recorded. Intra-articular temperatures rapidly dropped during icing. Five minutes of ice compress application resulted in a 2.2 ± 1.2°C intra-articular temperature drop with no change in rectal temperature. After 15 min of ice compress application, the joint temperature fell 4.1 ± 1.3°C with no change in rectal temperature. Thirty minutes of local ice compress application dropped the knee temperature 6.5 ± 4.0° C with a slight 0.5 ± 0.3° C drop in rectal temperature. Fifteen minutes of ice water immersion caused a much greater drop in intra-articular temperatures (20.2 ± 8.4° C) than could be achieved with ice compress. Rectal temperatures fell slightly during immersion (1.6 ± 0.3°C). After the removal of any type of cryotherapy, intra-articular temperatures continued to drop for several minutes and then a prolonged rewarming period commenced. The mean time required to return to baseline intra-articular temperature varied from 22-60 min, depending on the type and duration of cryotherapy. We conclude that brief periods of topical cold application to a dog's knee can induce significant and long lasting depression of intra-articular temperatures and that this is a local effect not dependent on core temperature cooling.
An LXXLL Motif in the Transactivation Domain of STAT6 Mediates Recruitment of NCoA-1/SRC-1*

Signal transducer and activator of transcription 6 (STAT6) regulates transcriptional activation in response to interleukin-4 (IL-4)-induced tyrosine phosphorylation by direct interaction with coactivators. The CREB-binding protein and the nuclear coactivator 1 (NCoA-1), a member of the p160/steroid receptor coactivator family, bind independently to specific regions of STAT6 and act as coactivators. In this study we show that an LXXLL motif in the STAT6 transactivation domain mediates the interaction with NCoA-1. Peptides representing this motif as well as antibodies generated against this motif inhibited STAT6/NCoA-1 interaction in glutathione S-transferase pulldown assays. Peptides derived from the STAT6 transactivation domain adjacent to the LXXLL motif as well as antibodies against these peptides showed no inhibitory effect. Mutagenesis of the LXXLL motif eliminated the STAT6/NCoA-1 interaction in vitro and in vivo, supporting the specific role of this motif in NCoA-1 binding. Importantly, mutagenesis of the STAT-LXXLL motif strongly diminished the IL-4-regulated activation of the endogenous STAT6 target gene eotaxin-3. Taken together, these results indicate that the STAT6-LXXLL-binding motif mediates the interaction with NCoA-1 in transcriptional activation and represents a new potential drug target for the inhibition of the STAT6 transactivation function in allergic diseases.
Stanford’s Graph-based Neural Dependency Parser at the CoNLL 2017 Shared Task

This paper describes the neural dependency parser submitted by Stanford to the CoNLL 2017 Shared Task on parsing Universal Dependencies. Our system uses relatively simple LSTM networks to produce part of speech tags and labeled dependency parses from segmented and tokenized sequences of words. In order to address the rare word problem that abounds in languages with complex morphology, we include a character-based word representation that uses an LSTM to produce embeddings from sequences of characters. Our system was ranked first according to all five relevant metrics for the system: UPOS tagging (93.09%), XPOS tagging (82.27%), unlabeled attachment score (81.30%), labeled attachment score (76.30%), and content word labeled attachment score (72.57%).
Fate of Fumonisin B1 in Naturally Contaminated Corn during Ethanol Fermentation

Two lots of corn naturally contaminated with fumonisin B1 (15 and 36 ppm) and a control lot (no fumonisin B1 detected) were used as substrates for ethanol production in replicate 8.5-liter yeast fermentations. Ethanol yields were 8.8% for both the control and low-fumonisin corn, while the high-fumonisin corn contained less starch and produced 7.2% ethanol. Little degradation of fumonisin occurred during fermentation, and most was recovered in the distillers' grains, thin stillage, and distillers' solubles fractions. No toxin was detected in the distilled alcohol or centrifuge solids. Ethanol fermentation of fumonisin-contaminated corn coupled with effective detoxification of distillers' grains and aqueous stillage is suggested as a practical process strategy for salvaging contaminated corn.
The natural course of anxiety symptoms in early adolescence: factors related to persistence

ABSTRACT Background and objectives: Anxiety disorders are the most common mental health problems during childhood and adolescence. This study examined the course of anxiety symptoms in early adolescents from the general population over three phases. Design: Prospective cohort study. Methods: Two hundred and forty-two participants (mean-age of 13.52) from a baseline sample of 1514 (mean-age of 10.23) were followed up three times. Of the 1514 children, those with emotional risk and controls without risk constituted the second-phase sample (n = 562; mean-age of 11.25). The Screen for Child Anxiety Related Emotional Disorders-SCARED was administered in all three phases. Results: Fifty-six percent and 32% of respondents showed total scores above the SCARED cutoff point at one and three years follow-up, respectively. Eight percent showed fluctuating symptoms. Fifty-five percent of respondents showed high scores for any subtype of anxiety over three years. Social phobia and generalized anxiety symptoms were the most prevalent and persistent. Participants with persistent separation anxiety showed the highest co-occurrence with symptoms of other psychopathological disorders. Participants with persistent anxiety showed lower academic performance. Being male was a protective factor against persistence. Conclusions: The data support anxiety maintenance during early adolescence. Early adolescence is a critical period which may involve other serious academic, social, and family problems.
Basal dialysate glycerol values and ethanol ratio in control probe , probe with phentolamine alone , or probe associated with propranolol in lean and in overweight subjects 120 min after placebo or tertatolol administration

Cedric Moro, Fabien Pillard, Isabelle de Glisezinski, Eva Klimcakova, Francois Crampes, Claire Thalamas, Isabelle Harant, Marie-Adeline Marques, Max Lafontan, and Michel Berlan Département Obésité et Métabolisme, Institut National de la Santé et de la Recherche Médicale, Unité 858, Institut de Médecine Moléculaire de Rangueil; Faculté de Médecine de Toulouse Service de Pharmacologie, Centre Hospitalier Universitaire; Hôpitaux Purpan et Larrey, Toulouse, France; Institut National de la Santé et de la Recherche Médicale, Franco-Czech Laboratory for Clinical Research on Obesity, Prague, Czech Republic; and Centre d Investigation Clinique, Hôpital Pur pan, Toulouse, France
Seven-year tolerability profile of glucocorticoids use in early rheumatoid arthritis: data from the ESPOIR cohort

Objective To explore the 7-year tolerability profile of glucocorticoids (GC) for early rheumatoid arthritis (RA). Methods We examined data for 602 patients with RA from the early arthritis Etude et Suivi des POlyarthrites Indifférenciées Récentes (ESPOIR) cohort (<6 months disease duration) stratified into two groups: with or without GC treatment at least once during follow-up (median 7 years (IQR 0.038–7.65)). The main outcome was a composite of death, cardiovascular disease (including myocardial ischaemia, cerebrovascular accident and heart failure), severe infection and fracture. Results Among the 602 patients with RA (476 women (79%), mean age 48±12 years), 386 with GC (64.1%) received low-dose prednisone (mean 3.1±2.9 mg/day for the entire follow-up): 263 started GC during the first 6 months (68%), and the mean duration of total GC treatment was 1057±876 days. As compared with patients without GC (216 (35.9%)), those with GC showed greater use of non-steroidal anti-inflammatory drugs, synthetic and biological disease-modifying antirheumatic drugs and had more active disease disability, higher C reactive protein and anticitrullinated protein antibody levels. Among 65 events (7 deaths, 14 cardiovascular diseases, 19 severe infections and 25 fractures), 44 and 21 occurred in patients with and without GC (p=0.520). Infections were more frequent, although not significantly, in patients with than without GC (p=0.09). On weighted Cox proportional-hazards analysis, with use of propensity score and inverse-probability-of-treatment weighting, and including age, gender, history of hypertension and GC treatment, outcomes did not differ with and without GC (p=0.520; HR=0.889; 95% CI 0.620 to 1.273). Conclusions This 7-year analysis of the ESPOIR cohort supports the good safety profile of very low-dose GC for early active RA.
Differences between ethnic and non ethnic-specific clinics for Portuguese-speaking mental health patients explained by providers ORIGINAL RESEARCH

Background: A previous quantitative study conducted in a health care system in a Northeastern U.S. metropolitan area identified greater adequacy of mental health care for Portuguese-speaking patients at a ethnic-specific Portuguese Mental Health Program (PMHP) compared to non ethnic-specific clinics. The objective of the present study was to un derstand, from a provider perspective, the disadvantages and difficulties of treating Portuguese-speaking immigrants with mental illness, and to elicit recommendations for improving care for this population. Methods: We conducted three interviews with providers using a structured interview guide that elicited questions related to the clinic, its patients, provider’s work, and ways in which the providers tailored mental health services to the Portuguese-speaking population. Responses were analyzed using content analysis, recording the frequency and saliency of particular words and phrases, and identifying keywords or repeated ideas. Results: Providers reported that the PMHP clinic is successful because it offers a unique set of services, provides services in the Portuguese language 100% of the time, and has existed for a long time in their community. Important differences between patients from Portugal and patients from Brazil include demographic characteristics, and patients’ and relatives’ feelings about seeking mental health treatment. Conclusion: This study supports policy recommendations to expand the availability of ethnic specific clinics. These clinics may play an especially important role in cost reduction and quality enhancement efforts being undertaken in urban safety net hospitals that serve a large number of individuals of racial/ethnic minority background.
Fundamental analysis of temperature-based transmission capacity constraints with high-penetration of PV generation considering a spatial smoothing effect

With extremely high penetration of intermittent renewable energy sources into power systems, transmission line currents are subject to significant fluctuation. However, in present power systems, the continuously allowable current in the line is generally determined on the basis of a steady-state line current condition. This paper evaluates transmission line capacity based on line conductor temperature and compares this with conventional line current constraints. Particularly, the authors utilize a low-pass filter model based on the transfer hypothesis from synchronized fluctuations to random fluctuations in order to consider the smoothing effect of solar irradiation. Through numerical simulation, we evaluate the influence of the smoothing effect on the difference between the conventional current limit and the proposed temperature-based transmission capacity limit.
[Orthodontic effects of palatal suture expansion].

INTRODUCTION The aim of the work was the determination of the possibility of the palatal suture expansion with an orthodontic method depending on the age of patients, and the assessment of orthodontic treatment results. MATERIAL AND METHODS The examination composed 40 individuals (24 female and 16 male) at the age of 10 and 6 months to 30 years and 1 month. Two groups were formed with regard to age. RESULTS The palatal suture expansion was obtained in 18 individuals (that is 100% of the examined) of the first group at the ages of 10 years and 6 months to 15 years and 5 months and in 12 individuals at the ages of 16 years and 4 months to 30 years and 1 month in the second group, which amounted to 54%. In 10 persons there was no palatal suture expansion. CONCLUSIONS The palatal suture expansion influenced in a statistically significant way an increase in the width of the palate, anterior and posterior width of the upper dental arch and a decrease in the index of the palatal height. The palatal suture expansion had no statistically significant influence on lowering the height of the palate and on the decrease in overbite, or changes in overjet. The age had no statistically significant influence on orthodontic changes. However, the age had a statistically significant influence on orthodontic changes assessed on the basis of the width of diastema.
EFFECTS OF CALCIUM ANTAGONISTS ON THE ALTERNATION OF THE ST‐T COMPLEX AND ASSOCIATED CONDUCTION ABNORMALITIES DURING CORONARY OCCLUSION IN DOGS

1 The effects of Ca2+‐antagonists on the relationships between alternate changes in the ST‐T complex in the epicardial electrogram, ST‐T alternans, and associated excitation‐conduction abnormalities during coronary occlusion were examined in anaesthetized dogs 2 Epicardial unipolar electrograms, bipolar electrograms (BPEG) and monophasic action potentials (MAP) were recorded with unipolar, composite and suction electrodes, respectively 3 ST‐T alternans was associated with serious conduction delay. During the period of ST‐T alternans, the amplitude of MAP changed alternately and the negative deflection of the ST‐T complex was associated with a larger MAP. A depression of the TQ level and decrease in the resting potential of MAP were marked 4 Verapamil (0.2 mg/kg) and diltiazem (0.5 mg/kg) inhibited ST‐T alternans, conduction abnormalities, TQ depression and changes in MAP. However, after these drugs, the TQ depression and the decrease in the resting potential were evident after a longer period of occlusion at a time when ST‐T alternans, conduction abnormalities and alternate changes in MAP were still inhibited. Dipyridamole (0.5 mg/kg) had no effect on either ST‐T alternans or the conduction abnormalities 5 Verapamil and diltiazem inhibited ST‐T alternans and the associated excitation and conduction abnormalities. The effects of these two drugs cannot be explained on the basis of attenuation of the decrease in the resting potential.
Major nutrient contents and their uptake by brinjal as influenced by phosphorus and sulphur

A pot experiment was conducted in the net house of the Department of Agricultural Chemistry, Bangladesh Agricultural University, Mymensingh to evaluate the influence of phosphorus (P) and sulphur (S) on major nutrient contents and their uptake by brinjal (cv. BARI brinjal-8) during the period from October, 2011 to May, 2012. The experiment was laid out in a completely randomized design with 12 treatments and 3 replications using four levels of P (0, 30, 60 and 90 kg P ha-1) and three levels of S (0, 15 and 30 kg S ha-1) along with the basal doses of urea, muriate of potash, boric acid, zinc oxide, cowdung and poultry manure. The study revealed that major nutrient contents and their uptake were significantly influenced by P and S interactions. They had positive significant effects on major nutrient contents and their uptake. Application of P increased N, P, K, Ca, Mg and S contents and their uptake upto 60 kg ha-1 and over the dose the values were reduced or near to control treatment. Similarly, the gradual increases of major nutrient contents and their uptake were found in S application upto 30 kg ha-1. Among the treatments the combination of P @ 60 kg ha-1 and S @ 30 kg ha-1 showed the highest N, P, K, S, Ca and Mg contents and their uptake. The lowest values were found in control treatment. Results showed that an appropriate interaction of P and S increased major nutrient contents of brinjal.
The Effects of Mild Perioperative Hypothermia on Blood Loss and Transfusion Requirement

Background:Anesthetic-induced hypothermia is known to reduce platelet function and impair enzymes of the coagulation cascade. The objective of this meta-analysis and systematic review was to evaluate the hypothesis that mild perioperative hypothermia increases surgical blood loss and transfusion requirement. Methods:The authors conducted a systematic search of published randomized trials that compared blood loss and/or transfusion requirements in normothermic and mildly hypothermic (34–36°C) surgical patients. Results are expressed as a ratio of the means or relative risks and 95% confidence intervals (CI); P < 0.05 was considered statistically significant. Results:Fourteen studies were included in analysis of blood loss, and 10 in the transfusion analysis. The median (quartiles) temperature difference between the normothermic and hypothermic patients among studies was 0.85°C (0.60°C versus 1.1°C). The ratio of geometric means of total blood loss in the normothermic and hypothermic patients was 0.84 (0.74 versus 0.96), P = 0.009. Normothermia also reduced transfusion requirement, with an overall estimated relative risk of 0.78 (95% CI 0.63, 0.97), P = 0.027. Conclusion:Even mild hypothermia (<1°C) significantly increases blood loss by approximately 16% (4–26%) and increases the relative risk for transfusion by approximately 22% (3–37%). Maintaining perioperative normothermia reduces blood loss and transfusion requirement by clinically important amounts.
Past, current, and future fire frequencies in Quebec's commercial forests : implications for the cumulative effects of harvesting and fire on age-class structure and natural disturbance-based management

The past decade has seen an increasing interest in forest management based on historical or natural distur- bance dynamics. The rationale is that management that favours landscape compositions and stand structures similar to those found historically should also maintain biodiversity and essential ecological functions. In fire-dominated land- scapes, this approach is feasible only if current and future fire frequencies are sufficiently low compared with the preindustrial fire frequency, so a substitution of fire by forest management can occur without elevating the overall fre- quency of disturbance. We address this question by comparing current and simulated future fire frequency based on 2 × CO2 and 3×C O2 scenarios to historical reconstructions of fire frequency in the commercial forests of Quebec. For most regions, current and simulated future fire frequencies are lower than the historical fire frequency, suggesting that forest management could potentially be used to maintain or recreate the age-class distribution of fire-dominated preindustrial landscapes. Current even-aged management, however, tends to reduce forest variability by, for example, truncating the natural age-class distribution and eliminating mature and old-growth forests from the landscape. There- fore, in the context of sustainable forest management, silvicultural techniques that retain a spectrum of forest composi- tions and structures at different scales are necessary to maintain this variability and thereby allow a substitution of fire by harvesting. 2744