Miracle-dz/UniFAR-FTUs huggingface dataset:
Adaptive Error-Prediction Flip-flop for performance failure prediction with aging sensors

This paper presents a new approach on aging sensors for synchronous digital circuits. An adaptive error-prediction flip-flop architecture with built-in aging sensor is proposed, performing on-line monitoring of long-term performance degradation of CMOS digital systems. The main advantage is that the sensor's performance degradation works in favor of the predictive error detection. The sensor is out of the signal path. Performance error prediction is implemented by the detection of late transitions at flip-flop data input, caused by aging (namely, due to NBTI), or to physical defects activated by long lifetime operation. Such errors must not occur in safety-critical systems (automotive, health, space). A sensor insertion algorithm is also proposed, to selectively insert them in key locations in the design. Sensors can be always active or at pre-defined states. Simulation results are presented for a balanced pipeline multiplier in 65 nm CMOS technology, using Berkeley Predictive Technology Models (PTM). It is shown that the impact of aging degradation and/or PVT (Process, power supply Voltage and Temperature) variations on the sensor enhance error prediction.
Primary prevention of type-2 diabetes and heart disease: action research in secondary schools serving an ethnically diverse UK population.

BACKGROUND Escalating rates of childhood obesity are likely to have an impact on the prevalence of coronary heart disease and type-2 diabetes. We aimed to identify barriers to healthy lifestyles and evaluate the effectiveness of an action research approach to lifestyle modification in secondary schools. METHODS An action research partnership between schools and university researchers involved pupils aged 11-15 in five inner-city secondary schools serving a predominantly South Asian population in Leicester, UK. Data collection included baseline and follow-up diet and physical activity questionnaires. Focus groups and observational visits were used to identify barriers, assist with developing tailored interventions and review the impact of the study. RESULTS Working with secondary schools presented challenges but a useful partnership was sustained. Qualitative feedback suggested that this had raised awareness of healthy lifestyle issues in participating schools. Barriers in pupils included low prioritization of health when making lifestyle choices. Sub-optimal diet and activity habits were identified at baseline. Overall, these persisted at follow-up, although some limited positive changes were identified. CONCLUSIONS Using action research methods in this context is challenging but can facilitate useful data collection and may have a modest impact on lifestyle behaviours.
Initial Delay in the Immune Response to Francisella tularensis Is Followed by Hypercytokinemia Characteristic of Severe Sepsis and Correlating with Upregulation and Release of Damage-Associated Molecular Patterns

ABSTRACT “Francisella tularensis subsp. novicida” intranasal infection causes a rapid pneumonia in mice with mortality at 4 to 6 days with a low dose of bacteria (102 bacteria). The short time to death suggests that there is a failure of the innate immune response. As the neutrophil is often the first cell type to infiltrate sites of infection, we focused on the emigration of neutrophils in this infection, as well as cytokines involved in their recruitment. The results indicated that there was a significant delay in the influx of neutrophils into the bronchoalveolar lavage fluid of F. tularensis subsp. novicida-infected mice. The delay in neutrophil recruitment in F. tularensis subsp. novicida-infected mice correlated with a delay in the upregulation of multiple proinflammatory cytokines and chemokines, as well as a delay in caspase-1 activation. Strikingly, the initial delay in the upregulation of cytokines through 1 day postinfection was followed by profound upregulation of multiple cytokines and chemokines to levels consistent with hypercytokinemia described for severe sepsis. This finding was further supported by a bacteremia and the cellular relocalization and release of high-mobility group box-1 and S100A9, both of which are damage-associated molecular pattern molecules and are known to be mediators of severe sepsis.
Long-term follow-up of surgically treated phantosmia.

OBJECTIVES To determine whether transnasal excision of olfactory epithelium is a safe, effective therapy and to learn more of the pathogenesis of phantosmia by studying the histological features of the excised mucosa. DESIGN A retrospective study consisting of a medical record review and telephone survey. Follow-up ranged from 1 to 11 years (average, 5.4 years). Excised tissues were histologically processed and descriptively compared with normal and other abnormal olfactory tissues. SETTING Tertiary university medical referral centers. PATIENTS All patients who presented to the primary author (D.A.L.) from 1988 to 1999 with unremitting phantosmia lasting longer than 4 years. INTERVENTION Olfactory testing and transnasal endoscopic excision of olfactory mucosa. MAIN OUTCOME MEASURES Tested olfactory function, patients' perception of phantom odor resolution, and histological findings. RESULTS Of 8 patients, 7 have complete and permanent resolution of their phantosmia. Postoperatively, the single nostril olfactory ability in the operated-on nostril is decreased in 2 nostrils, remains unchanged in 7, and is improved in 1. The excised olfactory mucosa generally shows a decreased number of neurons, a greater ratio of immature to mature neurons, and disordered growth of axons with some intraepithelial neuromas. CONCLUSIONS Surgical excision of olfactory epithelium is an effective and safe method to relieve phantosmia while potentially preserving olfactory ability. The abnormal histological features of the excised olfactory tissue suggest at least some pathological condition in the peripheral olfactory system. This nasal surgery requires intensive olfactory evaluation and follow-up. It is also extremely difficult with significant risks, and therefore should be limited to specialized centers.
In-Plane Field Effects on the Dynamics of Domain Walls in Ultrathin Co Films With Perpendicular Anisotropy

We studied how the application of an in-plane field affects the asymmetries of the domain nucleation activity and domain wall velocity revealed previously in ultrathin Co films with perpendicular anisotropy. It is established that the asymmetries survive and new effects arise under application of an additional field parallel to the film surface. It is found that the mobility of different parts of a circular domain wall vary drastically under application of additional planar field. The domain wall velocity in ultrathin Co films, unlike that in low-damping garnet films, slows down dramatically upon application of a planar field. The domain wall part that is moving perpendicular to the in-plane field direction decelerates most relative to the other parts of the domain wall. Moreover, domain wall parts moving in the same direction as the in-plane field and in the opposite direction have considerably different velocities. This anisotropy of domain wall velocity rotates with the field as the in-plane field direction is varied. A new asymmetry in the domain wall velocity in the presence of both in-plane and perpendicular fields is observed when the perpendicular field is reversed.
SDZ RAD, a new rapamycin derivative: synergism with cyclosporine.

BACKGROUND SDZ RAD is a new rapamycin analog with potent immunosuppressive activity. Compounds of the rapamycin class differ in their mode of action from cyclosporine, thus providing a rationale for potential synergism of these two potent immunosuppressants. METHODS The two-way mouse mixed lymphocyte reaction (BALB/c-CBA strain combination) was applied. Orthotopic kidney and heterotopic heart allografting was performed in the stringent DA-to-Lewis rat strain combination, with administration of compounds orally as microemulsion preconcentrate (i.e., Neoral in the case of cyclosporine). RESULTS Isobologram analysis of checkerboard titrations of SDZ RAD and cyclosporine in two-way mouse mixed lymphocyte reactions indicates a synergistic interaction in vitro. In vivo, the minimal effective dose of microemulsion cyclosporine giving long-term graft survival was 5.0 mg/kg/day; for SDZ RAD, the minimal effective dose was 5.0 mg/kg/day in kidney transplantation and >5.0 mg/kg/day in heart transplantation. Long-term allograft survival was noted for combinations of microemulsion cyclosporine administered at 1.0 or 2.0 mg/kg/day and SDZ RAD given at between 0.5 and 2.0 mg/kg/day. The index of synergy in different combinations ranged between 0.3 and 0.7. CONCLUSIONS SDZ RAD and cyclosporine show synergism in immunosuppression, both in vitro and in vitro. They form a promising synergistic drug combination in allotransplantation.
Babbling Complexity and Its Relationship to Speech and Language Outcomes in Children With Cochlear Implants

Objective: To investigate if babbling complexity in early childhood is related to speech and language outcomes in later childhood in children with cochlear implants (CIs). Study Design: Retrospective. Setting: Tertiary care hospital. Patients: Nineteen infants with CIs participated. Intervention: Infants received multichannel CIs. Main Outcome Measures: Infant vocal recordings were taken during pre- and post-CI visits up to 13 months post-CI. Vocalizations were measured using a scoring system that takes into account the phonetic complexity of infant vocalizations. Outcome variables included articulation and language measures collected at 4 years of age. Data were analyzed using correlational and regression analyses. Results: For infants with at least 6 to 9 months of CI experience, the phonetic complexity of babbling is significantly correlated with receptive vocabulary, articulation abilities, and global language skills at 4 years of age. Conclusion: The phonetic complexity of prelinguistic vocalizations is related to later speech and language outcomes in children with CIs. This information may be valuable in terms of tracking progress in pediatric CI users.
Mammary epithelial paracellular permeability in atopic and non‐atopic mothers versus childhood atopy

Sodium/potassium (Na/K) ratios are considered to be a marker of mammary epithelial paracellular permeability. The aim of the present study was to investigate the association between maternal atopy and Na/K ratios in breast milk and the association between Na/K ratios in breast milk and the development of atopy in the offspring. Early and mature milk samples were obtained from 30 atopic and 43 non‐atopic women. We found no differences in the Na/K ratios between atopic and non‐atopic women. At 18 months of age, 22 (30%) of the children had a positive skin prick test (SPT) and 26 (36%) had symptoms of atopic diseases. Overall, high levels of Na/K compared with low and slightly raised levels of Na/K in the maternal milk tended to be associated with a positive SPT and atopic disease. However, if the mother was atopic, high levels of Na/K in early or mature milk were associated with a significantly increased risk of a positive SPT or atopic disease in the offspring [RR = 4.8 (1.9–12)] whereas no such association was observed in non‐atopic mothers [RR = 0.8 (0.4–1.7), p for interaction = 0.001]. Thus, high Na/K levels in the breast milk may be associated with the development of atopy and atopic diseases in the offspring of atopic mothers.
Institutional Investor Preferences for Analyst Forecast Accuracy: Does Investment Strategy Matter?

In this study, we separate institutional investors into the categories of transient, dedicated, and quasi-indexer and examine whether the ownership percentages of these different types of institutional investors are associated with the accuracy of analysts’ earnings forecasts. We hypothesize a positive association between ownership by transient investors and earnings forecast accuracy, as forecast accuracy may be a signal of decreased price impact of trades and increased profit trading opportunities. We predict a negative association between ownership by dedicated investors and earnings forecast accuracy because more accurate forecasts eliminate dedicated investors’ informational advantage. Finally, we predict that forecast accuracy is not relevant for the investment decisions of quasi-indexers.Our empirical evidence suggests that transient investors are indeed drawn to companies with lower forecast errors and increase (decrease) their holdings when forecast errors decrease (increase). However, the evidence on the behavior of dedicated investors and quasi-indexers reveals more complex decision pattern, consistent with investment decisions not driven by analysts’ information. Dedicated investors’ ownership decreases with forecast accuracy, especially earnings are lower than forecasts, and are more likely to increase ownership levels when forecast accuracy decreases. Quasi-indexers appear to reduce ownership as forecast accuracy decreases, but only when earnings exceed forecasts.These findings highlight the importance to adjust for investors’ heterogeneity in research models rather than to cast institutional investors as a homogeneous group. Our findings also indicate that attempts to achieve "predictable earnings" appeal primarily to one type of institutional investors: transient.
Association of thyroid gland volume, serum insulin-like growth factor-I, and anthropometric variables in euthyroid prepubertal children.

CONTEXT AND OBJECTIVE Few studies have focused on the interrelation between thyroid size, anthropometric variables, and IGF-I in adults, but such data are lacking for children. We have investigated thyroid gland volume and several hormonal and anthropometric variables in prepubertal children. DESIGN AND PARTICIPANTS A total of 859 prepubertal euthyroid Danish children aged 4-9 yr underwent a thorough clinical investigation, including anthropometrical measurements and determination of TSH, thyroid hormones, autoantibodies, urinary iodine excretion, and thyroid volume (TV) by ultrasound. Longitudinal growth data from birth were available. RESULTS TV increased significantly with age (r = 0.487; P < 0.001). Mean TV +/- sd for different age groups were as follows: 4 yr, 2.2 +/- 1.4 ml; 5 yr, 2.5 +/- 1.3 ml; 6 yr, 2.8 +/- 1.3 ml; 7 yr, 3.2 +/- 1.3 ml; 8 yr, 3.5 +/- 1.3 ml; 9 yr, 3.7 +/- 1.3 ml. We found a significant positive association between IGF-I and TV (P < 0.001). Furthermore, in multiple regression analyses, TSH (P < 0.013), free T(4) (P < 0.001), lean body mass (P < 0.001), and body surface area (P < 0.001) as well as other anthropometrical measurements were identified as factors significantly associated with TV. Family history of thyroid disease and presence of incidental abnormal ultrasound findings were also positively associated with TV (P = 0.025 and 0.022, respectively). CONCLUSIONS In our cohort of prepubertal Danish children, the GH/IGF-I-axis was positively correlated with thyroid size, suggesting a role in the regulation of thyroid growth. Moreover, anthropometric measurements, in particular body surface area, were the best predictors of TV.
Incidence of Haemophilus influenzae type b meningitis in India.

BACKGROUND & OBJECTIVE Vaccine policy depends on locally relevant disease burden estimates. The incidence of Haemophilus influenzae type b (Hib) disease is not well characterized in the South Asian region, home to 30 per cent of the world's children. There are limited data from prospective population incidence studies of Hib in Asia, and no data available from India. We therefore carried out this study to assess the burden of Hib meningitis in India. METHODS A prospective surveillance study was carried out during 1997 and 1999 in hospitals for cases of Hib meningitis from 5 administrative areas of an Indian district (Vellore, Tamil Nadu) with 56,153 children under 5 yr of age, over a 24 month period RESULTS Ninety seven cases of possible meningitis (> 10 WBC/microl in CSF) were reported, an annual incidence of 86 per 100,000 (95%CI 69 to 109) in 0-4 yr old children, and 357 per 100,000 in 0-11 month infants. Eighteen had proven bacterial meningitis, an annual incidence of 15.9 per 100,000. Eight CSF had Hib by culture or antigen testing, an annual incidence of 7.1 per 100,000 (95%CI 3.1 to 14.0) in children 0-59 months. In infants 0-11 months of age, the incidence of Hib meningitis was 32 per 100,000 (95%CI 16 to 67) and in the 0-23 month group it was 19 (95%CI 8 to 37). INTERPRETATION & CONCLUSION Our data are the first minimal estimate of the incidence of Hib meningitis for Indian children. The observed incidence data are similar to European reports before Hib vaccine use, suggest substantial disease before 24 months of age, and provide data useful for policy regarding Hib immunization.
[Identification of subgroups with lower level of stroke knowledge using decision-tree analysis].

PURPOSE This study was performed to explore levels of stroke knowledge and identify subgroups with lower levels of stroke knowledge among adults in Korea. METHODS A cross-sectional survey was used and data were collected in 2012. A national sample of 990 Koreans aged 20 to 74 years participated in this study. Knowledge of risk factors, warning signs, and first action for stroke were surveyed using face-to-face interviews. Descriptive statistics and decision tree analysis were performed using SPSS WIN 20.0 and Answer Tree 3.1. RESULTS Mean score for stroke risk factor knowledge was 7.7 out of 10. The least recognized risk factor was diabetes and four subgroups with lower levels of knowledge were identified. Score for knowledge of stroke warning signs was 3.6 out of 6. The least recognized warning sign was sudden severe headache and six subgroups with lower levels of knowledge were identified. The first action for stroke was recognized by 65.7 percent of participants and four subgroups with lower levels of knowledge were identified. CONCLUSION Multi-faceted education should be designed to improve stroke knowledge among Korean adults, particularly focusing on subgroups with lower levels of knowledge and less recognition of items in this study.
Comparison of corneal flap thickness between primary and fellow eyes using three microkeratomes.

PURPOSE To compare corneal flap thickness created in laser in situ keratomileusis (LASIK) in primary (right) and fellow (left) eyes (same blade for both eyes) using three microkeratomes. METHODS The corneal thickness of 132 eyes (66 patients) was measured preoperatively and intraoperatively after flap creation. Corneal flap thickness was calculated by subtracting stromal bed thickness from total corneal thickness. Three microkeratomes were used: Nidek MK-2000, Bausch and Lomb Surgical Hansatome, and the Chiron Automated Corneal Shaper (ACS). Each patient had both corneas cut by one microkeratome and one blade at the same session. RESULTS Mean corneal flap thickness created in primary eyes was 128.30 +/- 12.57 microm (range 105 to 147 microm) for the ACS (160-microm plate and 8.5-mm ring) and 122.96 +/- 13.30 microm (range 86 to 140 microm) for fellow eyes; Hansatome (160-microm plate and 8.5-mm ring): 141.16 +/- 20.11 microm (range 101 to 169 microm) in primary eyes and 120.95 +/- 26.95 microm (range 107 to 151 microm) in fellow eyes; Nidek (130-microm plate and 8.5-mm ring): 127.25 +/- 4.12 microm (range 116 to 134 microm) in primary eyes and 127.54 +/- 3.7 microm (range 119 to 134 microm) in fellow eyes. The corneal flap in the ACS and Hansatome microkeratomes was always thicker in the primary than the fellow eye, using the same blade for both eyes. No significant difference was found using the Nidek microkeratome. CONCLUSION Corneal flap thickness tended to be thinner in fellow eyes than in primary eyes for the ACS and Hanstome microkeratomes. The Nidek microkeratome results were closer to specified corneal flap thickness than the ACS and Hanstome microkeratomes.
A survey of the emergency department population and their interest in preventive health education.

OBJECTIVE To determine which preventive health information the emergency department (ED) population (patients and visitors) would be most interested in having available to them while they spend time in the waiting area. METHODS This was a prospective survey of consecutive adults seated in the ED waiting area during a representative week on predetermined shifts. The survey asked them to indicate whether they would be interested in obtaining information about the following preventive health issues: breast cancer, prostate cancer, smoking, obesity, stress reduction, exercise programs, alcohol/drugs, HIV, blood pressure screening, immunizations, referrals to primary care physicians, Pap smears, car safety, smoke detectors, domestic and youth violence, depression, gun safety, and safe sex. RESULTS Of the 1284 subjects approached, 878 (68%) made up the study group (56% female, mean age = 44 years, 60% white); 406 refused. The information people were most interested in obtaining was the following: 52% of the respondents were interested in referral to stress reduction programs, 51% in information about exercise programs, 42% in blood pressure screening, 40% in information about breast cancer screening, 33% in depression information/screening, 33% in prostate cancer screening, 26% in immunization against pneumococcus, 24% in immunization against tetanus, 26% in smoking cessation programs, and 26% in safe driving information. Women were most interested in breast cancer screening (64%); and men, in prostate cancer screening (55%). CONCLUSIONS Of the 878 subjects in the study group, 96% were interested in obtaining information about one or more preventive health issues. An opportunity exists to respond to this interest by providing material for public health education in the waiting area of EDs.
The POU domain of SCIP/Tst-1/Oct-6 is sufficient for activation of an acetylcholine receptor promoter

In the PC12 neuroendocrine line, the neuronal nicotinic acetylcholine receptor alpha3 gene promoter is activated by SCIP/Tst-1/Oct-6, a POU domain transcription factor proposed to be important for regulating the development of specific neural cell populations. In this study, we have investigated the SCIP polypeptide domains involved in alpha3 promoter activation. The characteristics of activation by a chimeric effector in which the GAL4 DNA binding domain was substituted for the SCIP POU domain were dramatically different from those of wild-type SCIP. At low effector masses, the chimeric polypeptide weakly activated alpha3 in a GAL4 binding-site-dependent manner but then squelched transcription at higher masses. In contrast, wild-type SCIP activation was not modulated by the presence of multimerized SCIP binding sites, and squelching was not observed. Analysis of wild-type SCIP truncations revealed that deletion of the previously characterized SCIP amino-terminal activation domain did not destroy activity of the factor. Surprisingly, a truncation expressing nothing more than the POU domain was nearly as active as wild-type SCIP. Moreover, cotransfection of a GAL4-VP16 effector with an effector expressing just the SCIP POU domain resulted in synergistic activation of the promoter. Synergistic activation did not depend on an Sp1 motif that is the only functional alpha3 cis element outside the transcription start site region. Our results show that the DNA binding domain of a POU factor is capable of transcriptional activation probably through protein-protein interactions with components of the basal transcription complex.