Miracle-dz/UniFAR-FTUs huggingface dataset:
Endoscopic Versus Conventionanl Septoplasty: Our Institutional Experience

Purpose: To assess advantages and disadvantages of endoscopic septoplasty and to compare post-operative results and complications of endoscopic with conventional septoplasty. Materials and Methods: A total of 50 (fifty) patients with symptomatic deviated nasal septum were prospectively studied. Patients were divided into two equal groups. One group underwent endoscopic septoplasty and the other group underwent traditional septoplasty under general anaesthesia. A detailed history and thorough examinations were carried out on all selected patients, using a pre-designed proforma. Subjective and objective assessments were done both pre- and post-operatively. Patients were followed upto three months post-operatively. Comparisons were made for relief of symptoms of nasal obstruction, headache, recurrent rhinorrhoea,hyposmia and post nasal drip after the surgery in both the groups under study and also postoperative complaints like haemorrhage, facial swelling, nasal pain and duration of hospital stay in both the study groups. Appropriate statistical tools were used for analysis of datas. Results: In the study, there were 38 males (76%) and 12 females (24%). The most commonly affected subjects belonged to the 2nd and 3rd decade of life. The mean age was 28.00yrs with a Std. Deviation ± 8.64. In the study subjects, the most common pre-operative complaint was nasal obstruction (86%) followed by anterior nasal discharge (52%), headache (36 %), post nasal drip (44%) and hyposmia (14%). Subjectively 90% of patients who underwent endoscopic septoplasty (ES) and 82.60% of those who underwent traditional septoplasty (TS) were relieved of nasal obstruction while headache was relieved in 87.50 % of ES group and 60% of TS group. Rhinorrhoea, postnasal drip and hyposmia were relieved in 75%, 80% and 66.66% of ES group respectively, while these were relieved in 85.71%, 75% and 50% of TS group. The differences of symptomatic relief in both groups were statistically not significant (p> 0.05). Immediate complications like nasal bleeding, nasal pain, facial swelling and septal perforation following surgery were higher in traditional septoplasty group, but these were not statistically significant (p>0.05). Patients who underwent traditional septoplasty had longer hospital stay (>48 hrs) as compared to those who underwent endoscopic septoplasty (p 0.05). However, there was statistically significant residual posterior deviation and persistent spur between the groups (p<0.05). Synechia developed in 5(20%) of traditional group and none in endoscopic group, which was significant(p<0.05). Similar results were found during objective assessment at 03 month postoperatively.
Ultrasonic interferometry and X-ray measurements on MgO in a new diamond anvil cell

Abstract The compressional sound wave velocity, vp, of synthetic MgO in the (100) direction and the unitcell parameter have been measured up to a maximum pressure of 6.1 GPa using a new type of diamond-anvil cell. The main feature of the cell is the transverse access of the X-ray beam into the sample chamber. This allows us to undertake single crystal X-ray measurements while the ultrasonic attachment is mounted on the diamond-anvil cell. The sound velocity and the elastic parameter c11 have been determined from these measurements; the variation with pressure can be described by მc11/მp = 9.35(13), in good agreement with previous studies.
Platinum-based chemotherapy in triple-negative breast cancer.

1090 Background: There is increasing evidence that DNA repair defects characteristic of BRCA1-related cancers and triple negative breast cancer (TNBC) confer sensitivity to certain chemotherapeutic agents, such as platinums. However, prospective and retrospective studies comparing the efficacy of these agents versus conventional treatment in TNBC are lacking. The aim of this study was to evaluate the efficacy of platinum-based chemotherapy (PBC) in metastatic TNBC in terms of median duration of treatment and overall-survival (OS) and compare it to patients treated with conventional chemotherapy. METHODS We performed a retrospective chart review of patients with metastatic TNBC who received PBC from January 2007 to June 2010 treated at the Sunnybrook Odette Cancer Center. A case-control study was designed, with 3 controls per case matched by age, comprising metastatic TNBC treated with conventional agents. RESULTS A total of 116 patients were analyzed: 29 treated with PBC and 87 managed with conventional treatment. Median age at diagnosis was 47 years and distant disease-free interval was 27 months (m) for both groups. Patients treated with PBC had more sites of disease (100% vs. 70%, p<0.0001) and a worse performance status (ECOG 2 21% vs. 6%, p=0.034), respectively. Of the 29 patients treated with PBC, 79% received a combination regimen, most commonly weekly cisplatin and gemcitabine in 62% of patients. The median number of cycles delivered was 4 (2-11). 31% received PBC as first-line treatment, 35% as second-line, 28% as third-line and 7% as fifth-line. Only 2 patients discontinued PBC secondary to toxicity. The median time on treatment in first, second and third-line therapy was longer for the PBC group (5 vs. 2 m, p=0.225; 3 vs. 2 m, p=0.063; and 4 vs. 1 m, p=0.009). Patients treated with PBC had a longer OS compared to those managed conventionally (18 vs. 13 m, p=0.025). CONCLUSIONS PBC appears to improve clinical outcomes in patients with metastatic TNBC compared to those treated with conventional chemotherapy regimens. Although this is a retrospective study with its obvious limitations, it adds to the growing body of literature, suggesting the benefit of PBC in TNBC. Prospective trials are needed to confirm this benefit.
Characterization of Disability in Canadians with Mental Disorders Using an Abbreviated Version of a DSM-5 Emerging Measure: The 12-Item WHO Disability Assessment Schedule (WHODAS) 2.0

Objective: The World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) is a disability scale included in Section 3 of the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) as a possible replacement for the Global Assessment of Functioning Scale (GAF). To assist Canadian psychiatrists with interpretation of the scale, we have conducted a descriptive analysis using data from the 2012 Canadian Community Health Survey–Mental Health component (CCHS-MH). Methods: The 2012 CCHS-MH was a cross-sectional survey of the Canadian community (n = 23,757). The survey included an abbreviated 12-item version of the WHODAS 2.0. Mental disorder diagnoses were assessed for schizophrenia, other psychosis, major depressive episode (MDE), generalized anxiety disorder (GAD), bipolar I disorder, substance abuse/dependence, and alcohol abuse/dependence. Results: Mean scores ranged from 14.2 (95% CI, 14.1 to 14.3) for the overall community population to 23.1 (95% CI, 19.5 to 26.7) for those with schizophrenia, with higher scores indicating greater disability. Furthermore, the difference in scores between those with lifetime and past-month episodes suggests that the scale is sensitive to changes occurring during the course of these disorders; for example, scores varied from 23.6 (95% CI, 22.2 to 25.1) for past-month MDE to 14.4 (95% CI, 14.2 to 14.7) in the lifetime MDE group without a past-year episode. Conclusion: This analysis suggests that the WHODAS 2.0 may be a suitable replacement for the GAF. As a disability measure, even though it is not a mental health–specific instrument, the 12-item WHODAS 2.0 appears to be sensitive to the impact of mental disorders and to changes over the time course of a mental disorder. However, the clinical utility of this measure requires additional assessment.
Okul Müdürlerinin Örgüt Kültürü Algılarının İncelenmesi

Bu calismada, okul mudurlerinin okul kulturu algilarinin demografik degiskenlere bagli olup olmadigi sorusuna yanit aranmistir. Yontem olarak iliski arayici betimsel tarama modeli kullanilmistir. Arastirmanin calisma evrenini Gaziantep’teki tum resmi okullar olusturmaktadir, orneklemi ise rastlantisal kura yontemi ile belirlenen 144 okuldur. Okul mudurlerine Kreitner ve Kinicki (2001) tarafindan hazirlanan ve Kilic (2006) tarafindan gelistirip Turkceye uyarlanan ‘Cok Boyutlu Okul Kulturu Olcegi’ uygulanmistir. Arastirma sonucunda okul mudurleri algilarina gore okul oncesi okul mudurlerinin, lise ve ilkogretim mudurlerine gore daha az saldirgan savunmaci orgut kulturune sahip oldugu gorulmustur. 11 yil ve uzeri deneyime sahip okul mudurlerinin bulundugu okullarda orgut kulturlerinin, 5 yil ve alti deneyime sahip okul mudurlerinin bulundugu okullarin orgut kulturlerine gore fazla pasif savunmaci oldugu gozlenmistir
Student-facilitators' roles in moderating online discussions

Intellectual, social, managerial and technical are four commonly reported categories of facilitation in online discussions. The purpose of this study was to investigate whether these four broad categories of facilitation were equally applied in online discussions and which specific skills were perceived to be more important. In this study, students were facilitators of online discussions. Each student-facilitator led a group discussion and participated in two additional discussions moderated by other student-facilitators. Three groups of students were selected for data collection. Results indicated that the intellectual, social and managerial categories of facilitation were highly applied, while technical facilitation was less used in the online discussions. Also, summarising discussions was perceived to be the top facilitation skill. This paper presents findings of the study and discusses issues involved in the study. [ABSTRACT FROM AUTHOR]
A Novel Role of DNA Polymerase η in Modulating Cellular Sensitivity to Chemotherapeutic Agents

Genetic defects in polymerase η (pol η; hRad30a gene) result in xeroderma pigmentosum variant syndrome (XP-V), and XP-V patients are sensitive to sunlight and highly prone to cancer development. Here, we show that pol η plays a significant role in modulating cellular sensitivity to DNA-targeting anticancer agents. When compared with normal human fibroblast cells, pol η–deficient cells derived from XP-V patients were 3-fold more sensitive to β-d-arabinofuranosylcytosine, gemcitabine, or cis-diamminedichloroplatinum (cisplatin) single-agent treatments and at least 10-fold more sensitive to the gemcitabine/cisplatin combination treatment, a commonly used clinical regimen for treating a wide spectrum of cancers. Cellular and biochemical analyses strongly suggested that the higher sensitivity of XP-V cells to these agents was due to the inability of pol η–deficient cells to help resume the DNA replication process paused by the gemcitabine/cisplatin-introduced DNA lesions. These results indicated that pol η can play an important role in determining the cellular sensitivity to therapeutic agents. The findings not only illuminate pol η as a potential pharmacologic target for developing new anticancer agents but also provide new directions for improving future chemotherapy regimen design considering the use of nucleoside analogues and cisplatin derivatives. (Mol Cancer Res 2006;4(4):257–65)
Analysis of Slow Partial Halo CME Events with Velocity of 100-200 km/s: An Observation through CALLISTO System

Halo event of coronal mass ejections (CMEs) had been once in a while reported in coronagraph observations of the Sun before the Solar and Heliospheric Observatory (SOHO) mission has been carried out. However, since mid-1996 the SOHO Large Angle Spectrometric Coronagraph (LASCO) instruments have observed numerous halo or partial-halo CMEs. Partial halo is when CMEs aimed at Earth which is called as "halo events" because of the way they look in coronagraph images. As the expanding cloud of an Earth-directed CME becomes larger and it appears to envelop the Sun, forming a halo around our star. Statistical interpretation states that most of the halos CMEs occur at average speed of ~957 km/s. In 2015, eight (8) halo CMEs events were detected accompanied by slow partial halo CMEs. Sunspot number, solar radio flux and solar wind involves in interpreting the slow movements of halo CMEs. In this paper, we study partial halo CME events with slow velocity and we discussed the slow partial halo CMEs which is due to the weak magnetic fields affect from low solar radio flux and solar wind fluctuation. The slow halo CME events were observed through CALLISTO System and compare it with database from CACTUS. As a result, we found that there are slow halo CMEs occur with velocity as low as 100- 200km/s.
Antithrombotic effects of recombinant human soluble thrombomodulin (rhs‐TM) on arteriovenous shunt thrombosis in rats

We examined the antithrombotic effect of recombinant human soluble thrombomodulin (rhs‐TM) using an arteriovenous shunt thrombosis model and its influence on hemostasis in rats. Intravenous administration of rhs‐TM (0.5–4 mg/kg) significantly inhibited thrombus formation and prolonged ex vivo activated partial thromboplastin time (APTT) in a dose‐dependent manner. Thrombus formation was inhibited to the same extent in animals treated with heparin (25–200 U/kg) and in those treated with rhs‐TM (0.5–4 mg/kg), but heparin had a much stronger effect on prolonging APTT. In the hemorrhagic study using the rat template bleeding time method, rhs‐TM exhibited the prolongation of the bleeding time only at the highest effective dose (rhs‐TM; 4 mg/kg) of the thrombosis experiments. Thus, rhs‐TM exhibits the inhibitory effect on thrombus formation with less APTT prolongation in comparison with heparin and without significant pertubation of hemostasis. © 1994 Wiley‐Liss, Inc.
Influence of Flow Velocity on Tsunami Loss Estimation

Inundation depth is commonly used as an intensity measure in tsunami fragility analysis. However, inundation depth cannot be taken as the sole representation of tsunami impact on structures, especially when structural damage is caused by hydrodynamic and debris impact forces that are mainly determined by flow velocity. To reflect the influence of flow velocity in addition to inundation depth in tsunami risk assessment, a tsunami loss estimation method that adopts both inundation depth and flow velocity (i.e., bivariate intensity measures) in evaluating tsunami damage is developed. To consider a wide range of possible tsunami inundation scenarios, Monte Carlo-based tsunami simulations are performed using stochastic earthquake slip distributions derived from a spectral synthesis method and probabilistic scaling relationships of earthquake source parameters. By focusing on Sendai (plain coast) and Onagawa (ria coast) in the Miyagi Prefecture of Japan in a case study, the stochastic tsunami loss is evaluated by total economic loss and its spatial distribution at different scales. The results indicate that tsunami loss prediction is highly sensitive to modelling resolution and inclusion of flow velocity for buildings located less than 1 km from the sea for Sendai and Onagawa of Miyagi Prefecture.
Cyclosporin increases the density of angiotensin II subtype 1 (AT1) receptors in mouse medullary thick ascending limb cells.

BACKGROUND Cyclosporin A (CsA), a potent immunosuppressive agent, can be nephrotoxic. Because clinical studies have suggested that the intrarenal renin-angiotensin system may be involved in the mechanism responsible for CsA nephrotoxicity, we have analysed the effects of CsA on angiotensin II (Ang II) receptors in medullary thick ascending limb (mTAL) cells known to be sensitive to the action of CsA. METHODS Experiments were carried out on subcultured mouse mTAL cells. The expression of mRNA of Ang II subtype 1 and 2 (AT(1) and AT(2)) receptors was investigated using reverse transcription-polymerase chain reaction (RT-PCR). [(3)H]Ang II was used for radioligand and binding studies. Fluorimetric recordings using the fluorescent dye fura-2/AM were performed to determine the effect of CsA on the intracellular calcium ([Ca(2+)]i) content of untreated and Ang II-treated mTAL cells. RESULTS Subcultured mTAL cells expressed AT(1) and AT(2) Ang II receptor mRNAs, and binding studies revealed that the AT(1) receptors were the predominant Ang II receptor subtype ( approximately 90%) in mTAL cells. CsA (100 ng/ml, 24 h) increased (1.7-fold) the number of Ang II receptors (untreated, 315.8; +CsA, 543.6 fmol/mg protein) without altering the K(D) (untreated, 7.16; +CsA, 7.06 nM). CsA also significantly increased the level of [Ca(2+)]i measured in cultured mTAL cells both in the basal state (-CSA, 72.2; +CsA, 93.4 nM/10(6) cells) and in the presence of Ang II (-CSA, 97.8; +CsA, 206.3 nM/10(6) cells). CONCLUSIONS These findings suggest that the increase in Ang II AT(1) receptors and [Ca(2+)]i caused by CsA may be involved in the mechanism(s) responsible for CsA nephrotoxicity.
What drives cell morphogenesis: A look inside the vertebrate photoreceptor

Vision mediating photoreceptor cells are specialized light‐sensitive neurons in the outer layer of the vertebrate retina. The human retina contains approximately 130 million of such photoreceptors, which enable images of the external environment to be captured at high resolution and high sensitivity. Rod and cone photoreceptor subtypes are further specialized for sensing light in low and high illumination, respectively. To enable visual function, these photoreceptors have developed elaborate morphological domains for the detection of light (outer segments), for changing cell shape (inner segments), and for communication with neighboring retinal neurons (synaptic terminals). Furthermore, rod and cone subtypes feature unique morphological variations of these specialized characteristics. Here, we review the major aspects of vertebrate photoreceptor morphology and key genetic mechanisms that drive their formation. These mechanisms are necessary for cell differentiation as well as function. Their defects lead to cell death. Developmental Dynamics 238:2115–2138, 2009. © 2009 Wiley‐Liss, Inc.
Well-Conditioned Nyström Discretization of the Volume Integral Equation for Eddy Current Analysis

A well-conditioned, high-order Nyström discretization of a volume integral equation for quasi-magnetostatic, time-harmonic eddy current analysis of magnetic-conducting materials is presented. Good conditioning is contingent on augmenting the system with a charge neutrality constraint. Two forms of the continuity constraint are discussed. An iterative diagonal preconditioning scheme is applied to greatly improve the condition number. Results are presented for canonical problems and the TEAM Workshop Problem 7.
[Expression of HSP27 in colorectal carcinoma and its relationship with lymphatic metastasis].

OBJECTIVE To investigate the relationship between heat shock protein 27 (HSP27) expression and lymphatic metastasis of colorectal carcinoma (CRC). METHODS Immunohistochemistry was used to detect HSP27 expression in 68 specimens of human CRC. The expression of HSP27 mRNA and protein was also detected in two colorectal carcinoma cell lines with different lymphatic metastasis potentials by RT-PCR, Western blotting and immunohistochemistry. RESULTS HSP27 expression was not related to such clinicopathological factors as the patient's age, gender, histological grade, lymphatic metastasis or clinical stages (P>0.05), but overexpression of HSP27 showed significant inverse correlation to lymphatic metastasis of CRC (P=0.035). HSP27 mRNA and protein were expressed at low levels in SW620 cells with high potentials for lymphatic metastasis, and at high levels in SW480 cells that had low lymphatic metastasis potentials. CONCLUSION HSP27 expression can be inversely correlated to metastatic behavior of CRC cells, and may play a role in suppressing the metastasis of CRC.
Interferon‐γ cooperates with retinoic acid and phorbol ester to induce differentiation and growth inhibition of human neuroblastoma cells

The prognosis of patients with advanced stages of neuroblastoma with N‐myc amplification remains poor despite escalated therapy, a situation that has called for alternative therapeutic approaches. Neuroblastoma cells, which represent immature peripheral neuronal cells, treated with certain physiologic and nonphysiologic agents such as retinoic acid (RA), phorbol esters and interferons (IFN) in vitro undergo cellular differentiation and stop to divide, a process that mimics normal neuronal development. Such “differentiation therapy” using RA after autologous bone marrow transplantation has recently given encouraging results in neuroblastoma patients with advanced disease. Considering approaches for improved differentiation therapy, we investigated possible synergistic effects of combining agents known to influence neuroblastoma growth and differentiation in vitro. Our results show that combined treatment with IFN‐γ and RA or the phorbol ester 12‐O‐tetradecanoyl‐phorbol acetate (TPA) had synergistic or enhancing effects on morphologic differentiation and neurite outgrowth in 5 of 5 neuroblastoma cell lines, 3 of which expressed very high levels of N‐myc mRNA due to N‐myc amplification. The combinations RA+IFN‐γ or TPA+IFN‐γ also enhanced induced growth inhibition in all 5 cell lines, in several cases resulting in complete growth arrest under conditions where cells stimulated with either agent alone continued to grow. The phenotypic effects of the combined RA+IFN‐γ or TPA+IFN‐γ treatments were in most, but not all, investigated cases accompanied by moderate reductions in N‐myc expression, suggesting that the cooperative signals may counteract N‐Myc activity at several levels. The cooperativity between IFN‐γ and other differentiation signals may be relevant for approaches to improve the therapy for high‐risk neuroblastoma with N‐myc‐amplification. © 2001 Wiley‐Liss, Inc.
Abnormal Patella Height Based on Insall-Salvati Ratio and its Correlation with Patellar Cartilage Lesions: An Extremity-Dedicated Low-Field Magnetic Resonance Imaging Analysis of 1703 Chinese Cases

Background and aims: Diagnostic performance of patellar position for patellar cartilage lesions remains unclear. The aim of this study was to assess the abnormal patella height and its correlation with chondral lesions of the patellofemoral joint in China. Material and methods: A total of 1703 consecutive patients who performed knee joint examination using an extremity-dedicated low-field magnetic resonance imaging were enrolled in this study. Patellar cartilage lesions were diagnosed based on the result of magnetic resonance imaging and clinical data. Patella height was defined as the ratio of patellar tendon length to patellar length according to Insall-Salvati index. Patella alta and infera were defined as tendon length/patellar length >1.2 and <0.8, respectively. Results: The total prevalence of patellar cartilage lesions was 38.0%. The prevalence in females was significantly higher than that in males (46.4% vs 28.8%, p < 0.001). Age notably increased the incidence of patellar cartilage lesions (p < 0.001). Logistic regression analysis showed that tendon length/patellar length ratio was significantly correlated with patellar cartilage lesions (odds ratio = 6.380, p < 0.001). Furthermore, patients with cartilage lesions showed significantly higher rates of patella alta and infera (p < 0.001). In addition, receiver operating characteristic curve analysis demonstrated that abnormal patella height had statistical significance in diagnosing cartilage lesions (p < 0.001). However, the area under the curve (0.596; 95% confidence interval: 0.568–0.624) and sensitivity (47.0%) were relatively low, while the specificity was 72.2%. Conclusions: Patients with patellar cartilage lesions have an increased tendon length/patellar length ratio. The abnormal patella height is significantly correlated with chondral lesions and can be used as a potential diagnostic marker.