Miracle-dz/UniFAR-FTUs huggingface dataset:
An EEG-Based Cognitive Load Assessment in Multimedia Learning Using Feature Extraction and Partial Directed Coherence

Assessing cognitive load during a learning phase is important, as it assists to understand the complexity of the learning task. It can help in balancing the cognitive load of postlearning and during the actual task. Here, we used electroencephalography (EEG) to assess cognitive load in multimedia learning task. EEG data were collected from 34 human participants at baseline and a multimedia learning state. The analysis was based on feature extraction and partial directed coherence (PDC). Results revealed that the EEG frequency bands and activated brain regions that contribute to cognitive load differed depending on the learning state. We concluded that cognitive load during multimedia learning can be assessed using feature extraction and measures of effective connectivity (PDC).
Assessing Value in Organizational Knowledge Creation: Considerations for Knowledge Workers

To maintain competitive advantage, a firm's investment decisions related to knowledge creation are likely to be strategic in nature. However, strategic investments usually have an element of risk linked to uncertain and deferred investment benefits. To date, such investment decisions relating to knowledge workers have not been extensively researched. In this paper, we explore the following research question: How do we strategically assess knowledge creation over time giving consideration to complex decision criteria in order to improve organizational value? We develop a model based on economic and organization theory for assessing organizational value with regard to knowledge creation investments. Our model prototype provides managers with a learning tool relating to the timing and selection of knowledge creation investments. Our own use of the tool in simulation experiments yielded several insights which suggest that the decisions typically made by managers may dilute knowledge creation investments. Our results demonstrate that the organizational benefit of knowledge creation processes should be well aligned with near-term tasks. Under instances of high knowledge depreciation, however, it is unlikely that individual workers can optimize knowledge creation process decisions without organizational involvement in matching skills to task complexities. The organizational benefits of consistent and frequent knowledge creation process participation increase over time as the match of skills and task complexities improve.
Partial reversal of conduction slowing during repetitive stimulation of single sympathetic efferents in human skin.

AIMS To describe and identify the function of a class of human C fibre with an unusual response to repetitive electrical stimulation. Other C fibres slow progressively at 2 Hz (type 1), reach a latency plateau (type 2) or hardly slow at all (type 3). METHODS C fibres innervating hairy skin were recorded by microneurography in the superficial peroneal nerves of 19 healthy volunteers. Baseline electrical stimulation of the skin was at 0.25 Hz, and activity-dependent slowing recorded during stimulation at 2 Hz for 3 min and after a 3-min pause in stimulation. RESULTS In 41 units, there was a partial recovery of latency during repetitive stimulation. These were classified as 'type-4' units, and identified as sympathetic efferents, since they exhibited spontaneously activity, which was enhanced by manoeuvres that increase sympathetic outflow (15 of 16 cases) and/or suppressed by a proximal anaesthetic block (eight of eight cases). The peak slowing during 2 Hz trains averaged 6.47 +/- 2.06% (mean +/- SD, n=41), but after 3 min the slowing had reduced to 4.90 +/- 2.20%, which was less than in all type 1 (nociceptor) fibres but similar to that in type 2 (cold) fibres. Compared with cold fibres, type-4 sympathetic fibres slowed more after the first 10 impulses at 2 Hz (2.57 +/- 0.45%) and also after a pause in stimulation (1.66 +/- 0.51%). CONCLUSIONS The distinctive activity-dependent slowing profiles of these type-4 sympathetic C units may help identification in vitro, and suggest that hyperpolarization-activated channels have a particularly prominent role in the axonal membrane.
Design, Fabrication and Connectorization of High-Performance Multimode Glass Waveguides for Board-Level Optical Interconnects

Fiber fly-overs are deployed for on-board optical interconnects in combination with on-board optical engines in different products such as high-performance switches for data centers. Polymer waveguides are a promising next step technology solution for integrated board-level optical connectivity to increase the interconnection density, their drawback is the high optical loss at key optical wavelengths around 1310 nm and 1550 nm where promising low-cost silicon photonic transceivers will operate. Glass waveguides fabricated by silver ion-exchange in glass panels have attracted significant interest as a cost-effective candidate due to their very low optical loss at key wavelengths and efficient coupling to optical fiber. The glass waveguide technology and board integration of glass waveguides have been demonstrated for multimode waveguides. Still, the performance of glass waveguides can be optimized by adjusting the refractive index profile for the specific requirements of complex circuits with small pitch, high-number of crossings and tight bends. Low insertion and cross-talk losses are important requirements. For off board communication a reliable connector solution is required for multi-fiber interconnection.
Annexin V inhibits phosphatidylserine-induced intrauterine growth restriction in mice.

To investigate the role of phosphatidylserine (PS) derived from the activated platelets in placental circulation, we established an artificial PS-induced intrauterine growth restriction (IUGR) model in mice and examined whether annexin V, a PS-binding anticoagulant protein, could prevent the development of IUGR in the animal experiments. The ICR mice were injected in the tail vein on days 8, 11 and 14 of pregnancy with filtered PS/phosphatidylcholine (PC) microvesicles (<0.3 microm in maximal diameter). The microvesicles have a procoagulant activity which was inhibited by annexin V in a dose-dependent fashion. The mice were killed on day 18 of pregnancy and the placental and fetal weights were measured. The placental tissue specimens were examined microscopically. PS/PC vesicles induced significant reductions in fetal weights compared with PC vesicles alone. The placental tissue revealed severe congestion with fibrin depositions although the lung and kidney tissue specimens showed minimal histological changes. PS/PC microvesicles with recombinant annexin V showed no significant reductions in fetal weights in mice with PS/PC vesicles alone. These results suggest that PS from the activated platelets induces IUGR by enhancing the coagulation cascade in the placental circulation and that annexin V from the villous trophoblast prevents the development of IUGR.
The Electrical Restitution Curve Revisited:

The electrical restitution curve (ERC) traditionally describes the recovery of action potential duration (APD) as a function of the interbeat interval or, more correctly, the diastolic interval (DI). Often overlooked in modeling studies, the normal ventricular ERC is triphasic, starting with a steep initial recovery at the shortest DIs, a transient decline, and a final asymptotic rise to a plateau phase reached at long DIs. Recent studies have proposed that it would be advantageous to lower the slope of the ERC by drug intervention, as this might reduce the potential for electrical alternans and ventricular fibrillation. This review discusses the pros and cons of a flat versus steep slope of the ERC and draws attention to mechanisms that justify the (physiologically) steep slope, rather than a flat slope, as a better design against arrhythmias. Five potential mechanisms are discussed, which allows for a different interpretation of the effect of the slope on arrhythmogenicity. The most important appears to be the physiologic rate adaptive shortening of APD that, by reciprocal lengthening of the DI, allows the subsequent APD to move more quickly from the steep initial ERC phase onto the flat phase. A less steep initial ERC phase would protract the transition toward more fully recovered APD and, in fact, may perpetuate electrical alternans. The triphasic ERC time course in normal myocardium cannot be explained by or fitted to single exponentials or single ion channel recovery kinetics. A simple tri‐ionic model is suggested that may help explain the shape of the ERC at various repolarization levels and place APD recovery into perspective with intracellular calcium recycling and recovery of contractile force. (J Cardiovasc Electrophysiol, Vol. 14, pp. S140‐S147, October 2003, Suppl.)
Identification of Nudix Hydrolase Family Members with an Antimutator Role in Mycobacterium tuberculosis and Mycobacterium smegmatis

ABSTRACT Mycobacterium tuberculosis and Mycobacterium smegmatis MutT1, MutT2, MutT3, and Rv3908 (MutT4) enzymes were screened for an antimutator role. Results indicate that both MutT1, in M. tuberculosis and M. smegmatis, and MutT4, in M. smegmatis, have that role. Furthermore, an 8-oxo-guanosine triphosphatase function for MutT1 and MutT2 is suggested.
Improving Speech Recognition in Noise: Directional Microphone and FM Systems

Recent estimates suggest that over 29 million individuals in the United States exhibit some degree of hearing impairment (National Institutes of Deafness and Communication Disorders (NIDCD). A major consequence of sensorineural hearing loss (SNHL) is communicative difficulty, especially with the addition of noise and/or reverberation (Dubno, Dirks and Morgan 1984; Hawkins and Yacullo 1984; Suter 1985; Helfer and Wilber 1990; Crandell 1991; Helfer and Huntley 1991; Needleman and Crandell 1995; Killion 1997a; Moore 1997). Unfortunately, conventional amplification with omnidirectional microphone technology may provide little or no improvement to the signal-to-noise ratio (SNR) in adverse listening environments (Duquesnoy and Plomp 1983; Plomp 1986; Crandell and Smaldino 2000; 2001). In fact, a lack of perceptual improvement in noisy listening environments is one of the major reasons why individuals with SNHL report dissatisfaction with and reject amplification (Kochkin 1994). At present, there are various technologies that have been shown to improve speech recognition in poor listening environments. These technologies include directional microphones and personal frequency modulation (FM) systems (Hawkins and Yacullo 1984; Hawkins 1984; Fabry 1994; Valente, Fabry and Potts 1995; Gravel, Fausel, Liskow and Chobot 1999; Kuk, Kollofski, Brown, Melum and Rosenthal 1999; Pittman, Lewis, Hoover and Stelmachowicz, 1999; Preves, Sammeth and Wynne 1999; Ricketts and Dhar, 1999; Pumford Seewals, Scollie and Jenstad
Comparison of Tibial Rotation Strength in Patients’ Status After Anterior Cruciate Ligament Reconstruction With Hamstring Versus Patellar Tendon Autografts

Objective:To determine if there are tibial rotational strength deficits in individuals treated with a semitendinosus/gracilis or bone-patella tendon-bone (BTB) autografts for ACL reconstruction. Design:Retrospective. Setting:Clinical practice and nonprofit research site. Patients:102 subjects—34 treated with BTB autograft, 34 treated with a hamstring autograft, and 34 matched controls—were evaluated at an average of 53.1 ± 36.0 months postoperatively. Main Outcome Measurements:Isokinetic examination at 60, 120, and 180°/s to assess internal (IT) and external tibial (ET) rotation peak torque of the operated knee and contralateral knee. Internal and external tibial rotation peak torque values were evaluated for differences between gender and surgery type (2 × 3 ANOVA). Results:Contrasts of IT torque across groups revealed that surgery type exhibited a significant main effect (P < 0.0001), but gender did not (P = 0.07), and there was no interaction of surgery and gender (P = 0.64). The hamstring group was weaker in IT rotation compared with the BTB and control groups (P < 0.05). No difference was noted in IT rotation torque between BTB and control groups at all test velocities. Contrasts of ET rotation torque across groups revealed that surgery type exhibited a significant main effect (P < 0.0001), but gender did not (P = 0.48). There was no interaction of surgery and gender (P = 0.98). The BTB group was significantly weaker compared with the hamstring group (P < 0.001) and the control group (P < 0.001) in ET at all test velocities. Conclusions:Residual strength deficits in IT and ET rotation following hamstring graft and BTB graft ACL reconstruction are apparent.
Cerebral hemispherectomy in pediatric patients with epilepsy: comparison of three techniques by pathological substrate in 115 patients.

OBJECT Cerebral hemispherectomy for intractable seizures has evolved over the past 50 years, and current operations focus less on brain resection and more on disconnection. In addition, cases involving cortical dysplasia and Rasmussen encephalitis are being identified and surgically treated in younger individuals. Few studies have been conducted to compare whether there are perioperative differences based on hemispherectomy technique and/or pathological substrate in pediatric patients with epilepsy. METHODS In this study the authors compared, stratified by disease, anatomical (37 cases) and Rasmussen functional hemispherectomy (32 cases) with a new modified lateral hemispherotomy (46 cases). Pathological processes included cortical dysplasia (55 cases), Rasmussen encephalitis (21 cases), infarction/ischemia (27 cases), and other/miscellaneous (12 cases). The authors found differences in perioperative clinical factors based on operative technique and/or pathological substrate. In terms of technique, the lateral hemispherotomy was associated with the least intraoperative blood loss, shortest intensive care unit stay, and lowest complication rate. The anatomical hemispherectomy was associated with the longest hospital stay, delayed oral food intake, highest postsurgery fevers, and the highest incidence of shunt requirement. The functional hemispherectomy was associated with the highest reoperation rate for recurrent seizures (25%). In terms of pathology, patients with cortical dysplasia were the youngest at surgery, suffered the greatest amount of blood loss, and required the longest operative/anesthesia times compared with the other pathologically defined groups. Postoperative seizure control (range 0.5-2 years) was not statistically different according to technique or disease process and was similar to that in cases of pediatric temporal lobe epilepsy. CONCLUSIONS The authors found differences in perioperative risks and hospital course but not postsurgery seizure control, which vary by hemispherectomy technique and/or disease process. The modified lateral hemispherotomy approach offers various advantages related to operative blood loss and reoperation compared with anatomical and functional hemispherectomies that are especially relevant in younger patients with cortical dysplasia and Rasmussen encephalitis with small and/or malformed ventricles.
Risk factors for cerebral edema in children with diabetic ketoacidosis. The Pediatric Emergency Medicine Collaborative Research Committee of the American Academy of Pediatrics.

BACKGROUND Cerebral edema is an uncommon but devastating complication of diabetic ketoacidosis in children. Risk factors for this complication have not been clearly defined. METHODS In this multicenter study, we identified 61 children who had been hospitalized for diabetic ketoacidosis within a 15-year period and in whom cerebral edema had developed. Two additional groups of children with diabetic ketoacidosis but without cerebral edema were also identified: 181 randomly selected children and 174 children matched to those in the cerebral-edema group with respect to age at presentation, onset of diabetes (established vs. newly diagnosed disease), initial serum glucose concentration, and initial venous pH. Using logistic regression we compared the three groups with respect to demographic characteristics and biochemical variables at presentation and compared the matched groups with respect to therapeutic interventions and changes in biochemical values during treatment. RESULTS A comparison of the children in the cerebral-edema group with those in the random control group showed that cerebral edema was significantly associated with lower initial partial pressures of arterial carbon dioxide (relative risk of cerebral edema for each decrease of 7.8 mm Hg [representing 1 SD], 3.4; 95 percent confidence interval, 1.9 to 6.3; P<0.001) and higher initial serum urea nitrogen concentrations (relative risk of cerebral edema for each increase of 9 mg per deciliter [3.2 mmol per liter] [representing 1 SD], 1.7; 95 percent confidence interval, 1.2 to 2.5; P=0.003). A comparison of the children with cerebral edema with those in the matched control group also showed that cerebral edema was associated with lower partial pressures of arterial carbon dioxide and higher serum urea nitrogen concentrations. Of the therapeutic variables, only treatment with bicarbonate was associated with cerebral edema, after adjustment for other covariates (relative risk, 4.2; 95 percent confidence interval, 1.5 to 12.1; P=0.008). CONCLUSIONS Children with diabetic ketoacidosis who have low partial pressures of arterial carbon dioxide and high serum urea nitrogen concentrations at presentation and who are treated with bicarbonate are at increased risk for cerebral edema.
Physician Career Satisfaction: Examining Perspectives of the Working Environment

Abstract The author examined the relationship among factors influencing the career satisfaction of 2,105 physicians. Data from the 2005 Community Tracking Study Physician Survey were used to obtain 5 latent factors. Structural equation modeling was then applied to extract information on factor interrelationships with physician satisfaction. The main results indicate that underinsurance is negatively associated with physician career satisfaction. Thus, spillover effects that are related to decreased physician satisfaction may increase with greater proportions of underinsurance.
On Representing Information: A Characterization of the Analog/Digital Distinction

The common account of the analog vs digital distinction is based on features of physical systems, being related to the usage of continuous vs discrete supports respectively. It is proposed here to alternatively characterize the concepts of analog and digital as related to coding systems, of which a formal definition is given, by suggesting that the distinction refers to the strategy adopted to define the coding function: extensional in digital systems, isomorphic intensional in analog systems. This thesis is supported by examples, in particular of analog systems exploiting discrete supports, and is discussed to explain why digital coding is currently so widespread in technological and social practice.
Screening for alcohol problems in the U.S. general population: comparison of the CAGE, RAPS4, and RAPS4-QF by gender, ethnicity, and service utilization. Rapid Alcohol Problems Screen.

BACKGROUND The purpose of this study was to compare the performance (sensitivity and specificity) of two brief screening instruments, CAGE and the Rapid Alcohol Problems Screen 4 (RAPS4), against ICD-10 and DSM-IV criteria for alcohol dependence and abuse in a representative sample of the U.S. adult household population by gender, ethnicity, and service utilization (emergency room and primary care) in the last year. METHODS Data are from the Alcohol Research Group's 2000 National Alcohol Survey (n = 7612), which is a computer-assisted telephone interview survey of the U.S. general population 18 and over in all 50 U.S. states and the District of Columbia. RESULTS Sensitivity of the RAPS4 (0.86) was better than the CAGE (0.67) given similar specificity (0.95 vs. 0.98) and outperformed the CAGE for alcohol dependence across all gender, ethnic, and service utilization groups, except among blacks and Hispanics. The RAPS4 also performed equally well for females and males (0.88 vs. 0.85), whereas sensitivity of the CAGE was lower for females. Although sensitivity of the RAPS4 was better than the CAGE for alcohol abuse, sensitivity was low for both (0.56 and 0.36, respectively). When quantity-frequency (QF) questions (drinking five or more drinks on at least one occasion during the last year and drinking as often as once a month during the last year) were added to the RAPS4, the RAPS4-QF performed significantly better for alcohol abuse and outperformed the CAGE at a cut point of one across all gender, ethnic, and service utilization groups. The RAPS4-QF appeared to be most sensitive for alcohol abuse among both males and females reporting emergency room use (0.90). CONCLUSIONS The data suggest that the RAPS4 outperforms the CAGE in this general population sample. The addition of a QF question to the RAPS4 improves performance in relation to sensitivity for alcohol abuse, and the RAPS4 and RAPS4-QF may be the instruments of choice in brief screening for alcohol use disorders. Additional research is needed to further explore these issues.
Genetic analysis of somatic cell score and udder type traits in South African Holstein cows

Selection accuracy for resistance to mastitis may be increased by combining somatic cell score (SCS) and udder type into an udder health index, using genetic parameter estimates among them. A multi-trait animal model was used to estimate genetic parameters among lactation average SCS and udder type traits in South African Holstein cattle, through REML procedures. Data comprised records on 22 999 Holstein cows in 722 herds, collected through the National Milk Recording Scheme from 1996 to 2002. Average SCS in the first three lactations (SCS1, SCS2, SCS3) were considered as different traits and the udder type traits were fore udder attachment (FUA), rear udder height (RUH), udder cleft (UC), udder depth (UD), fore teat length (FTL) and fore teat placement (FTP). Heritability estimates for SCS were 0.19 ± 0.02, 0.17 ± 0.02 and 0.19 ± 0.02, respectively for SCS1, SCS2 and SCS3. Udder type traits had heritability estimates ranging from 0.13 ± 0.01 for UC to 0.34 ± 0.01 for FTL. The genetic correlations between lactation SCS ranged from 0.82 ± 0.04 to 0.99 ± 0.03 for correlations of SCS3 with SCS1 and SCS2, respectively. Genetic correlations between SCS and udder type traits were in the range -0.01 ± 0.07 between FUA and SCS3 to -0.38 ± 0.04 between UD and SCS1 and SCS2. Slow genetic progress is expected when selection is applied independently on SCS and udder type traits, due to the generally low heritability estimates. Low, shallow udders with narrowly placed teats are associated with low SCS in the South African Holstein population. Keywords : Genetic parameters, mastitis, selection accuracy, udder health South African Journal of Animal Science Vol. 38 (1) 2008: pp. 1-11