Miracle-dz/UniFAR-FTUs huggingface dataset:
Walnuts (Juglans regia) Chemical Composition and Research in Human Health

Walnuts are among the most widely consumed commercially grown tree nuts in the world. Many health benefits have been claimed for the consumption of these, including reduced risk of cardiovascular disease, coronary heart disease, type II diabetes treatment, and prevention and treatment of certain cancers, and the lessening of symptoms attributed to age-related and other neurological disorders. The health-promoting benefits of walnut consumption are ascribed to its fatty acid profile, which is rich in polyunsaturated fatty acids with a particularly high ω3:ω6 ratio—the highest among all the tree nuts. The content of polyphenols and other phytochemicals in walnuts, with their claimed cytotoxic properties, also make them an attractive candidate for research for the prevention of free radical-induced nucleic acid damage. Research of walnut consumption in humans and animals employing a range of data sets and statistical methods suggest that walnuts may be considered a safe potential nutraceutical or possibly pharmaceutical substance. Nevertheless, few reviews of scientific research on the proposed benefits of these nuts exist, in spite of the numerous claims attributed to them in the lay media. This brief review article attempts to disseminate much of the information surrounding walnut consumption, and human health benefits, to other scientists and the interested general reader.
Feeding ecology of the fish ectoparasite Gnathia sp. (Crustacea: Isopoda) from the Great Barrier Reef, and its implications for fish cleaning behaviour

The feeding rate of a parasitic gnathiid isopod on fish was examined. Individual fish, Hemigymnus melapterus, were exposed to gnathiid larvae and sampled after 5, 10, 30, 60, and 240 min. I recorded whether larvae had an engorged gut, an engorged gut containing red material, or had dropped off the fish after having completed engorgement; variation among sampling times and larval stages was analyzed using generalized linear mixed model analyses. The likelihood that larvae had an engorged gut increased with time and varied with larval stage. First stage ( 1.45 mm) larvae. After 30 min, however, most (>93%) larvae had an engorged gut regardless of their larval stage. The likelihood of red material in the gut of third stage larvae increased over time (46% after 30 min, 70% after 60 min, and 86% after 240 min) while that of first and second stage larvae remained relatively low (<27%) at all times. First and second stage larvae left the fish at a higher rate (approximately 23% after 30 min and 81% after 60 min) than third stage larvae (3% after 30 min and 26% after 60 min). After 60 min, however, the likelihood that larvae dropped off fish did not change. The variation in feeding behaviour with larval stage is likely due to variation in their diet and gut volume. The rapid feeding rate of gnathiid larvae suggests that their turnover rate on fish is high. This may explain why some fish species seek cleaner fish, which eat many gnathiid larvae, so often. By repeatedly visiting cleaner fish, gnathiids may also be removed from hosts before the parasites become fully engorged.
Effectiveness and safety of new oxycodone/acetaminophen formulations with reduced acetaminophen for the treatment of low back pain.

OBJECTIVE To evaluate the analgesic effectiveness/safety of the new oxycodone 7.5- and 10-mg/acetaminophen 325-mg (Percocet) formulations in patients with low back pain (LBP) suboptimally responsive to nonsteroidal anti-inflammatory drugs, muscle relaxants, tramadol, cyclo-oxygenase-2 inhibitors, and/or prn opioids. DESIGN Prospective, open-label, nonrandomized, 4-week trial. SETTING Multicenter. PATIENTS Thirty-three men and women (mean age: 52.2 years) with LBP (mean duration: 10.9 years). INTERVENTIONS All prior analgesics were discontinued, and oxycodone/acetaminophen was dosed three times a day (TID), titrated to clinically meaningful pain relief. Initial oxycodone/acetaminophen dose: 2.5/325 mg TID; maximum: 20/650 mg TID. OUTCOME MEASURES Effectiveness: Brief Pain Inventory (BPI) and Neuropathic Pain Scale 4 score (sharp, hot, dull, and deep pain). Quality of life: BPI and North American Spine Society Lumbar Spine questionnaire. SAFETY Adverse events, physical/neurologic examinations, vital signs, and clinical laboratory tests. RESULTS In all, 28 of 33 patients (85%) completed the study; discontinuations were for adverse events (N=3), patient choice (N=1), and lack of effectiveness (N =1). The mean oxycodone/acetaminophen dose at the end of treatment was 8.2/325 mg TID. After 4 weeks, treatment significantly reduced BPI pain intensity and improved pain relief (P < 0.0005), improved Neuropathic Pain Scale 4 score (P =0.007), reduced pain interference with quality of life (P < 0.0004), and reduced disability (P < 0.0001). Treatment was found to be safe and well tolerated. Adverse events were those most commonly expected from an opioid, and most were of mild-to-moderate intensity. CONCLUSIONS The primary purpose of this study was to preliminarily test the effectiveness of the new formulations of oxycodone/acetaminophen with reduced acetaminophen in the clinical practice setting. The results from this trial suggest that these formulations are effective in the treatment of moderate-to-severe chronic LBP. Most patients (67%) reported significant pain relief/tolerable side effects with a TID dosing frequency or less (mean: 3.04 doses/day), suggesting chronic pain patients can experience meaningful pain relief with around-the-clock dosing of oxycodone/acetaminophen and minimal risk of hepatotoxicity. Further long-term, controlled studies of the efficacy/safety of the new formulations of oxycodone/acetaminophen in LBP are warranted to fully characterize efficacy in this patient population and corroborate the findings from our study.
A literature review of the individual and systems factors that contribute to medication errors in nursing practice.

AIM This paper reports a review of the empirical literature on factors that contribute to medication errors. BACKGROUND Medication errors are a significant cause of morbidity and mortality in hospitalized patients. This creates an imperative to reduce medication errors to deliver safe and ethical care to patients. METHOD The databases CINAHL, PubMed, Science Direct and Synergy were searched from 1988 to 2007 using the keywords medication errors, medication management, medication reconciliation, medication knowledge and mathematical skills, and reporting medication errors. RESULTS Contributory factors to nursing medication errors are manifold, and include both individual and systems issues. These include medication reconciliation, the types of drug distribution system, the quality of prescriptions, and deviation from procedures including distractions during administration, excessive workloads, and nurse's knowledge of medications. IMPLICATIONS FOR NURSING MANAGEMENT It is imperative that managers implement strategies to reduce medication errors including the establishment of reporting mechanisms at international and national levels to include the evaluation and audit of practice at a local level. Systematic approaches to medication reconciliation can also reduce medication error significantly. Promoting consistency between health care professionals as to what constitutes medication error will contribute to increased accuracy and compliance in reporting of medication errors, thereby informing health care policies aimed at reducing the occurrence of medication errors. Acquisition and maintenance of mathematical competency for nurses in practice is an important issue in the prevention of medication error. The health care industry can benefit from learning from other high-risk industries such as aviation in the prevention and management of systems errors.
Malate Dehydrogenase Isozymes Provide a Phylogenetic Marker for the Piciformes (Woodpeckers and Allies)

HOWARTH, B. 1971. Transport of spermatozoa in the reproductive tract of turkey hens. Poultry Sci. 50: 84-89. LAKE, P. 1975. Gamete production and the fertile period with particular reference to domesticated birds. Symp. Zool. Soc. London 35: 225-244. MERO, K. N. , • F. X. OGASAWARA. 1970. Dimensions of uterovaginal sperm-storage tubules of the chicken and their possible significance in sperm release. Poultry Sci. 49: 1304-1308. PAL, D. 1977. Histochemistry of the utero-vaginal junction with special reference to the sperm-host glands in the oviduct of the domestic duck. Folia Histochem. Cytochem. 15: 235-242. VAN DRIMMELEN, G. C. 1946. "Spermnests" in the oviduct of the domestic hen. J. S. African Vet. Med. Assoc. 17: 43-52.
Gene expression profiling identifies responsive patients with cancer of unknown primary treated with carboplatin, paclitaxel, and everolimus: NCCTG N0871 (alliance).

BACKGROUND Carboplatin (C) and paclitaxel (P) are standard treatments for carcinoma of unknown primary (CUP). Everolimus, an mTOR inhibitor, exhibits activity in diverse cancer types. We did a phase II trial combining everolimus with CP for CUP. We also evaluated whether a gene expression profiling (GEP) test that predicts tissue of origin (TOO) could identify responsive patients. PATIENTS AND METHODS A tumor biopsy was required for central confirmation of CUP and GEP. Patients with metastatic, untreated CUP received everolimus (30 mg weekly) with P (200 mg/m(2)) and C (area under the curve 6) every 3 weeks. The primary end point was response rate (RR), with 22% needed for success. The GEP test categorized patients into two groups: those having a TOO where CP is versus is not considered standard therapy. RESULTS Of 45 assessable patients, the RR was 36% (95% confidence interval 22% to 51%), which met criteria for success. Grade ≥3 toxicities were predominantly hematologic (80%). Adequate tissue for GEP was available in 38 patients and predicted 10 different TOOs. Patients with a TOO where platinum/taxane is a standard (n = 19) tended to have higher RR (53% versus 26%) and significantly longer PFS (6.4 versus 3.5 months) and OS (17.8 versus 8.3 months, P = 0.005), compared with patients (n = 19) with a TOO where platinum/taxane is not standard. CONCLUSIONS Everolimus combined with CP demonstrated promising antitumor activity and an acceptable side-effect profile. A tumor biomarker identifying TOO may be useful to select CUP patients for specific antitumor regimens. CLINICALTRIALSGOV NCT00936702.
P‐glycoprotein activity in human Caucasian male lymphocytes does not follow its increased expression during aging

P‐glycoprotein (P‐gp) is a transmembrane protein that mediates the efflux of innumerous structurally unrelated compounds. It was initially found over‐expressed in tumor cells, associated to a multidrug resistance phenotype (MDR). Then, P‐gp was found constitutively expressed in excretory cells/tissues and in circulating cells, such as lymphocytes. Considering the importance of this transporter in the establishment of therapeutic protocols and the existence of contradictory results, this study aimed at evaluating the influence of aging in the expression and function of P‐gp in human lymphocytes, comparing two different methodologies to assess both parameters. P‐gp activity and expression were evaluated in lymphocytes isolated from whole blood samples of 65 healthy caucasian male donors, divided into two groups according to age (group 1: under 30‐years old; group 2: above 60‐years old). P‐gp expression was assessed using the anti‐P‐gp monoclonal antibody, UIC2, in the presence and in absence of vinblastine (Vbl). P‐gp activity was evaluated measuring the efflux rate of the fluorescent P‐gp substrate rhodamine 123 (Rho 123) and also using UIC2 shift assay. Flow cytometric analysis was performed to assess all the proceedings. Furthermore, P‐gp expression and each of the P‐gp activity determination methods were compared, through correlation analysis and linear regression models. We observed a significant age‐dependent increase in mean P‐gp expression (p = 0.029), which was not reflected in the transporter's activity (p > 0.050). Statistical analysis allowed selection of UIC2 shift assay over Rho 123 efflux assay as a more selective method to assess P‐gp activity. Despite the significant correlation between P‐gp expression and P‐gp activity found in lymphocytes (Gp1(group 1)—r = 0.609, p < 0.001; Gp2—r = 0.461, p = 0.012), using UIC2 shift assay, these data reinforce the need for P‐gp activity assessment, rather than P‐gp expression determination alone, when starting new therapeutic regimens with P‐gp substrates, especially in men older than 60 years of age. © 2011 International Society for Advancement of Cytometry
Amelioration of Glomerulosclerosis by Satureja khozestanica Essential Oil in Alloxan-Induced Diabetic Rats

Article history: Received: 10 Mar 2013 Accepted: 28 May 2013 Available online: 25 Nov 2013 ZJRMS 2014 Oct; 16(10): 23-26 Background: Satureja khuzestanica, an endemic plant of Iran, has been reported to be used traditionally to treat diabetes. We examined possible protective effect of Satureja khozestanica essential oil (SKE) on glomerulosclerosis in alloxan-induced type 1 diabetic rats. Materials and Methods: In this experimental study, 30 Sprage-dawley male rats were divided into 3 groups randomly; group 1 as control, group 2 diabetic untreated, and group 3 treatments with SKE by 500 ppm in drinking water, respectively. Diabetes was induced in the second and third groups by alloxan injection subcutaneously. After 8 weeks, animals were anaesthetized; livers and kidneys were then removed immediately. Kidney paraffin sections were prepared and stained by periodic acid Schiff method. Glomerular volume and leukocyte infiltration were estimated by stereological rules and glomerular sclerosis was studied semi-quantitatively. Results: Flow treatment of diabetic animals with SKE could significantly inhibit glomerular hypertrophy (22%) leukocyte infiltration (31%) and glomerulosclerosis (20%) in comparison with the diabetic untreated group. Conclusion: The findings showed that SKE alleviates loss of glomerular volume, leukocyte infiltration, and glomerulosclerosis and exerts beneficial effects on the lipid peroxidation in alloxan-induced type 1 diabetic rats. Copyright © 2014 Zahedan University of Medical Sciences. All rights reserved.
A PLL-Based Multirate Structure for Time-Varying Power Systems Harmonic/Interharmonic Estimation

This paper describes a phase-locked-loop (PLL)-based power systems harmonic estimation algorithm, which uses an analysis filter bank and multirate processing. The filter bank is composed of bandpass filters. The initial center frequency of each filter is purposely chosen to be equal to harmonic frequencies. However, an adaptation strategy makes it possible to track time-varying frequencies as well as interharmonic components. A downsampler device follows the filtering stage, reducing the computational burden, especially because undersampling operations are performed. Finally, the last stage is composed of a PLL estimator which provides estimates for amplitude, phase, and frequency of the input signal. The proposed method improves the accuracy, computational effort, and convergence time of the previous harmonic estimator based on cascade PLL configuration.
Rubinstein–Taybi syndrome type 2: report of nine new cases that extend the phenotypic and genotypic spectrum

Rubinstein–Taybi syndrome (RTS) is an autosomal dominant neurodevelopmental disorder characterized by growth deficiency, broad thumbs and great toes, intellectual disability and characteristic craniofacial appearance. Mutations in CREBBP account for around 55% of cases, with a further 8% attributed to the paralogous gene EP300. Comparatively few reports exist describing the phenotype of Rubinstein–Taybi because of EP300 mutations. Clinical and genetic data were obtained from nine patients from the UK and Ireland with pathogenic EP300 mutations, identified either by targeted testing or by exome sequencing. All patients had mild or moderate intellectual impairment. Behavioural or social difficulties were noted in eight patients, including three with autistic spectrum disorders. Typical dysmorphic features of Rubinstein–Taybi were only variably present. Additional observations include maternal pre-eclampsia (2/9), syndactyly (3/9), feeding or swallowing issues (3/9), delayed bone age (2/9) and scoliosis (2/9). Six patients had truncating mutations in EP300, with pathogenic missense mutations identified in the remaining three. The findings support previous observations that microcephaly, maternal pre-eclampsia, mild growth restriction and a mild to moderate intellectual disability are key pointers to the diagnosis of EP300-related RTS. Variability in the presence of typical facial features of Rubinstein–Taybi further highlights clinical heterogeneity, particularly among patients identified by exome sequencing. Features that overlap with Floating–Harbor syndrome, including craniofacial dysmorphism and delayed osseous maturation, were observed in three patients. Previous reports have only described mutations predicted to cause haploinsufficiency of EP300, whereas this cohort includes the first described pathogenic missense mutations in EP300.
A short‐term sublethal in situ toxicity assay with hediste diversicolor (polychaeta) for estuarine sediments based on postexposure feeding

This study evaluated a short‐term sublethal endpoint for in situ toxicity assays for estuarine sediments, based on postexposure feeding of the polychaete Hediste (Nereis) diversicolor Müller. A method for precisely quantifying postexposure feeding rates of H. diversicolor was established under laboratory conditions using Artemia franciscana Kellog nauplii. The sensitivity of the postexposure feeding response to copper was investigated by comparing postexposure feeding rates to growth and lethality. The 48‐h and 96‐h median lethal concentration (LC50) of copper were 241 and 125 μg/L, respectively, whereas the 48‐h median inhibitory concentration (IC50) for postexposure feeding and the 20‐d IC50 for growth were 52 and 25 μg/L of copper, respectively. The influence of different exposure conditions (substrate, temperature, salinity, food availability, and light) on H. diversicolor postexposure feeding was assessed; temperature and salinity were found to influence significantly postexposure feeding. The effectiveness of the proposed in situ assay was investigated by deploying it at two reference and six contaminated Portuguese estuaries. A 48‐h exposure period was followed by a 1‐h postexposure feeding period. High organism recoveries (89–100%) were obtained. Postexposure feeding was depressed significantly (17–90%) at all contaminated sites relatively to reference sites. The proposed in situ assay with H. diversicolor was shown to be a potential useful tool for estuarine sediment toxicity testing.
Divergent Role of Gamma Interferon in a Murine Model of Pulmonary versus Systemic Klebsiella pneumoniae Infection

ABSTRACT Klebsiella pneumoniae is a leading cause of both community-acquired and nosocomial gram-negative-bacterial pneumonia. A further clinical complication of pulmonary K. pneumoniae infection is dissemination of bacteria from the lung into the peripheral blood, resulting in bacteremia concurrent with the localized pulmonary infection. Here, we report studies detailing the divergent role of gamma interferon (IFN-γ) in pulmonary versus systemic K. pneumoniae infection. Intratracheal inoculation of IFN-γ knockout mice resulted in significantly increased mortality compared to that observed for wild-type infected animals. Increased mortality correlated with a 100-fold increase in pulmonary bacteria within 2 days postinfection and upregulation of lung-associated interleukin-10 (IL-10) mRNA. Interestingly, IFN-γ knockout mice had a twofold reduction in plasma aminospartate transferase activity, indicating diminished liver injury following peripheral blood bacterial dissemination. To study the host response towards blood-borne bacteria in the absence of the ongoing pulmonary infection, intravenous inoculation studies were initiated. IFN-γ knockout mice were no more susceptible to intravenous infection than their wild-type counterparts. The consistent observation in IFN-γ knockout mice was for improved survival correlating with increased clearance of blood- and liver-associated bacteria. Intravenous inoculation resulted in a two- to threefold increase in hepatic IL-10 production 24 and 48 h postinfection. Liver injury was also significantly reduced in IFN-γ knockout mice. These data indicate that IFN-γ secretion is a critical mediator in the resolution of localized gram-negative pulmonary pneumonia. Surprisingly, host responses towards systemic infection with the same bacteria appear to be IFN-γ independent.
Electromagnetic Design of a 15 MW-Class HTS Flux Switching Synchronous Generator considering Mechanical Stress of the Rotor Core

This paper introduces a novel flux switching synchronous generator (FSSG) using high-temperature superconducting (HTS) field coils. Unlike conventional superconducting synchronous generators, the HTS field coils in the proposed FSSG are mounted in the stator and do not rotate during operation. Therefore, the design and fabrication of the cooling and excitation systems for HTS field coils are easier than those for the conventional superconducting synchronous generator. To verify the feasibility of the structure, a 15 MW-class FSSG was designed using a fundamental design methodology considering the mechanical stress of the rotor core. The design methodology uses mechanical and electromagnetic equations. It defines the size of the rotor first using mechanical equations for the rotor and designs the HTS field winding and armature winding using the electromagnetic equations and an FEM analysis. In addition, the operational characteristics of the FSSG were analyzed by a transient motion analysis using the FEM program. This paper could be utilized to develop superconducting synchronous generators.
Water Balance Estimates of Evapotranspiration Rates in Areas with Varying Land Use

In the continental United States, approximately 2/3 of all rainfall delivered is lost to evapo‐ transpiration (ET; US Water Resource Council, 1978). It follows that the ET rate, representing the combined processes of physical evaporation and biological transpiration, is essential for predicting water yields, designing irrigation and supply projects, managing water quality, quantity, and associated environmental concerns, and negotiating disputes, contracts, or treaties involving water. Water fluxes in catchments are controlled by these physical and biological processes as well as by hydrogeologic properties that are complex, heterogeneous, and poorly characterized by field and laboratory measurements. As a result, practical theories of ET rates and their impact on runoff generation and catchment hydrology remain elusive.