Miracle-dz/UniFAR-FTUs huggingface dataset:
Implementation Strategies to Increase Uptake of Hester Davis Tool Tailoring of Fall Prevention Interventions

Introduction. Falls are the most common cause of injury to patients in acute care hospitals globally and higher incidences of falls with injury are reported in the hospitalized elderly. Falls can result in physical and emotional injury, long-term pain, functional impairment, disability, loss of income, increased hospital stay and mortality. Research demonstrates individualized, multifactorial fall prevention interventions are most beneficial in preventing falls and related injuries. This paper reports whether accurate fall risk assessment using the Hester Davis, proactive use of 5T’s (toileting, tolerating pain, tidy, turn, technology), appropriate gait belt use, individualized interventions and intentional toileting for patients with altered mental status and impaired mobility reduce falls in the neuroscience (NS) unit. Methods. The Promoting Action on Research in Health Sciences framework guided the project in a 22 bed NS settings at a large Midwestern hospital. Staff (N= 40), received education with pre-/post-tests. A multi-faceted evidenced based fall prevention intervention was implemented. Results. A significant improvement in fall prevention knowledge was identified. One fall occurred in the six weeks post-implementation; a clinically meaningful reduction in falls. There was no difference in the number of call light/bed alarms. Conclusion. Accurate fall assessment, along with providing 5T’s, appropriate gait belt use and intentional toileting decreases falls. Further audits are necessary to evaluate improvements and sustained benefits. Implications. Patient safety is the number one priority in hospitals. Multifactorial individualized fall prevention interventions reduce incidence of falls in hospitals.
Research on Personalized Recommendation Algorithm Based on Ontological User Interest Model

A user interest model based on user interest ontology is proposed to deal with the lack of semantic information and the user interest changing over time of user model in personalized recommendation system nowadays. The automatically updating procedure and algorithm of user interest model is described in detail based on Spreading Activation Theory. Using the ontological user interest model in the collaborative recommendation, the target user’s similar neighbors are selected by calculating the semantic similarity of user’s interest models, not referring to the rating of candidate items, and generate personalized recommendation items with the opinions of neighbors. Using movie rating data from Movielens, experiment results demonstrate that this recommendation algorithm offers improved MEA, recommendation diversity and cold-start performance. Finally, the stability of user interest model is analyzed
Dietary Intake, D3Cr Muscle Mass, and Appendicular Lean Mass in a Cohort of Older Men.

BACKGROUND We examined cross-sectional associations between dietary patterns, macronutrient intake, and measures of muscle mass and lean mass in older men. METHODS Participants in the Osteoporotic Fractures in Men (MrOS) cohort (n = 903; mean ± SD age 84.2 ± 4 years) completed brief Block food frequency questionnaires (May 2014-May 2016); factor analysis was used to derive dietary patterns. The D3-creatine (D3Cr) dilution method was used to measure muscle mass; dual-energy x-ray absorptiometry (DXA) was used to measure appendicular lean mass (ALM). Generalized linear models were used to report adjusted means of outcomes by dietary pattern. Multiple linear regression models were used to determine associations between macronutrients and D3Cr muscle mass and DXA ALM. Multivariable models were adjusted for age, race, clinic site, education, depression, total energy intake, height, and percent body fat. RESULTS Greater adherence to a Western dietary pattern (high factor loadings for red meat, fried foods, and high-fat dairy) was associated with higher D3Cr muscle mass (p-trend = .026). Adherence to the Healthy dietary pattern (high factor loadings for fruit, vegetables, whole grains, and lean meats) was not associated with D3Cr muscle mass or DXA ALM. Total protein (β = 0.09, 95% CI = 0.03, 0.14) and nondairy animal protein (β = 0.16, 95% CI = 0.10, 0.21) were positively associated with D3Cr muscle mass. Nondairy animal protein (β = 0.06, 95% CI = 0.002, 0.11) was positively associated with DXA ALM. Associations with other macronutrients were inconsistent. CONCLUSIONS Nondairy animal protein intake (within a Western dietary pattern and alone) was positively associated with D3Cr muscle mass in older men.
Significance of the PIK3CA mutations in the differential diagnosis of ovarian epithelial carcinoma.

Background: Ovarian carcinoma, one of the most common gynecological malignancies in Central and Eastern Europe, is characterized by a clinical and genetic heterogeneity with a distinct molecular signature for each histologic subtype. Materials and methods: Here, we established the frequency of the PIK3CA mutations and amplifications in 100 FFPE tissues with the initial diagnosis of serous ovarian carcinoma. Accordingly, the diagnostic value of combining morphology with genetic and immunohistochemical testing was estimated in this cohort. Results: The PIK3CA mutations and amplifications were found in 4.1% (4/97) and 7.2% (7/97) of samples, respectively with a higher prevalence in low-grade tumors (p=0.0121). All identified variants were classified as pathogenic missense mutations, located within the PIK3CA mutational hotspots. In the light of the molecular and immunohistochemical results, two tumors with the somatic PIK3CA mutations and strongly positive expression for PI3K and hNF1β were eventually re-classified from serous to clear cell carcinomas after pathological re-evaluation. Conclusions: These findings demonstrate that the PIK3CA mutational screening facilitated establishing an accurate diagnosis of ovarian carcinomas and, more importantly, might allow for personalized treatment optimization. As the PIK3CA mutations result in the PI3K/AKT pathway deregulation, the individuals with the somatic PIK3CA variants may be eligible for personalized targeted therapies with PI3K inhibitors.
Nursing intervention with hospitalized children mediated by therapeutic toys

To know the opinion of the nursing team professionals about the importance of therapeutic toys as a strategy of humanization in the nursing intervention with hospitalized children. Action research with mixed approach developed in a pediatric public hospital in Imperatriz, Maranhão, Brazil, in July 2016 with the nursing team. All professionals like working with kids and find the use of therapeutic toys important to nursing care. They believe toys represent a tool that humanizes care, because they facilitate the service, help improving communication, lessen trauma/fear and promote security. Some problems were identified: these included the lack of material, insufficient staff size, high demand of patients, there is little time available and inadequate environment. The use of Therapeutic Toys by the Nursing team transforms their professional practice; nurses believe in the use of the technique as allied to their plans of care and as a tool to humanize it.
APPLICATION OF THE JOINT MODELLING OF SERIAL ANTHROPOMETRIC MEASURES AND MORTALITY AMONGST CHILDREN FOLLOWING HOSPITALIZATION WITH A COINCIDENT ACUTE INFECTIOUS DISEASE IN ADDITION TO SEVERE ACUTE MALNUTRITION

Background: Malnutrition continues to be a major health burden in developing countries. It is globally the most important risk factor for illness and death, with hundreds of millions of young children particularly affected. The mid-upper arm circumference (MUAC) and the standardized weight-for- length Z-score (WFLz) are two anthropometric measures that are used for the diagnosis of malnutrition. The two anthropometric measures have poor correlation in terms of their predictive capabilities. Design: A joint model was applied to data collected recently in a randomized, double blind, placebo-controlled trial to see which of these two anthropometric measures would be the better predictor of mortality in infants who were admitted to hospital with severe acute malnutrition and later discharged and followed up for one year. Typically longitudinal measures and event time data are modelled jointly by introducing shared random effects or by considering conditional distributions together with marginal distributions. Participants: The study population comprised of 1781 children admitted to hospital with evidence of an acute infectious disease and with severe malnutrition and who had care initiated and were stabilized. Results: Joint modelling showed that While WFLz was not significantly associated with mortality (p=0.202); MUAC had a high association with mortality (p=0.014) and was a predictor of children at risk of post-discharge mortality. Conclusion: Using joint modelling approach, MUAC was identified as superior predictor of mortality amongst children treated for complicated SAM.
The Relation of Left Ventricular Diastolic Dysfunction and Increased Left Ventricular Mass with Blood Pressure Variability in Non-Established Hypertensive Patients

Background: long term high blood pressure is a major risk factor for coronary artery disease, stroke, heart failure, peripheral vascular disease, vision loss and chronic kidney disease.Objective: the aim of this study is to demonstrate the relation between left ventricular diastolic dysfunction, increased left ventricular mass and ambulatory blood pressure recording in subjects not known to be hypertensive. Patients and Methods: this study is cross sectional study that was carried out on (100) normotensive patients in Cardiology Department Clinic at Matrouh Specialized Cardiothoracic and Interventional Catheterization Center from October, 2017 to January 2019. Results: significantly marked difference in left ventricular (LV) mass between two groups (normal blood pressure and latent hypertension) and significantly marked difference in diastolic dysfunction. According to (normal circadian and impaired circadian) there is significant difference between the two major groups in sex wheremale >female and marked difference in LV mass between the two groups (normal circadian and impaired circadian) and in smoking. Conclusion: ambulatory blood pressure (AMBP) plays an important role as a predictor to estimate prevalence of hypertension based on diastolic dysfunction and increased left ventricular mass in persons with normal blood pressure measures at office specially masked hypertension in white coat hypertensive patients.
Using a computer simulation to enhance students' conceptual development : a pilot study

Within Higher Education (HE) the ability to understand, interpret and evaluate quantitative research findings is an essential skill. Students need to understand how data are gathered and analysed, how results and findings are derived and how to analyse and critically evaluate their own research findings and those from the literature. In Sports Studies, as in most disciplines, research methods and statistics are core components of undergraduate courses. Anecdotally, and from the author’s own experience, modules with a perceived high level of mathematics content (e.g. research methods and biomechanics) are considered by students as difficult. This perception may, in part, be due to the varied mathematical background of the student intake, a contention supported by research (Crawford et al, 1998). Furthermore, earlier results by the same authors (1994) indicated that, “over 75% of students conceive of mathematics as a fragmented body of knowledge and learn it using repetitive and surface approaches”. It is well documented (Biggs, 1979; Entwistle & Ramsden, 1983; Marton & Saljo, 1976) that students whose learning occurs through making abstractions or connections in order to derive meaning concerning reality are likely to adopt "deep" approaches to study, while students who conceive of learning in terms of discrete increases in the knowledge base are likely to adopt a "surface" approach.
The Role of T Cells in Muscle Damage Protective Adaptation

The Role of T Cells in Muscle Damage Protective Adaptation Michael Roger Deyhle Department of Exercise Sciences, BYU Doctor of Philosophy Skeletal muscle is prone to damage from a range of stimuli. The muscle repair process that ensues is complex, involving several phases and requiring the participation of many different cell types. Among the cells involved are various immune cells including neutrophils, macrophages, monocytes, and eosinophils. More recently, T cells were added to this list of immune cells known to participate in effective muscle repair from traumatic injuries in mice. We recently published data showing that T cells also accumulate in human muscle following contraction-induced damage. These data suggested that T cells might be involved an adaptation known as the repeated bout effect that renders muscle protected from future damage after an initial exposure. This document contains research on the role of the immune system, particularly T cells, in the “repeated bout effect. ”
Role of Various Mediators in Inflammation of Asthmatic Airways

The degree of airway inflammation is directly related to asthma severity and associated hyper-responsiveness. Airway inflammation is categorized into three types: (a) acute asthmatic inflammation featured by early recruitment of cells into the airways, (b) subacute asthmatic inflammation involving activation of recruited cells in continual inflammation, and (c) chronic inflammation characterized by cellular damage. T-helper lymphocytes, the key factor in the pathogenesis of bronchial asthma, induce B cells to synthesize and secrete IgE through production of IL-4 and induce eosinophil-mediated inflammation. Mediators such as histamine, PG, leukotrienes, and kinins contract airway smooth muscle, increase microvascular leakage, increase airway mucus secretion, and attract other inflammatory cells into airway epithelia that initiate mucociliary clearance signaling pathways through special Toll-like receptor 4 expressed on epithelial cells activated by allergic and infectious triggers. These cells form barrier against mechanical stress, oxidant stress, allergens, pollutants, infectious agents, and leakage of endogenous solutes. Various adhesion molecules and costimulatory factors also promote infiltration of inflammatory cells at the site of inflammation.
An Unusually Large Fibroepithelial Polyp of Uterine Cervix: Case Report and Review of Literature

BACKGROUND: Fibroepithelial cervical polyps (FEPs) are benign growths protruding from the inner surface of the cervix. They are typically asymptomatic, but a very small minority can undergo malignant change. Giant cervical polyps with a size greater than 4 cm are rare entities with only 23 reported cases in the literature. Cervical polyps develop as a result of focal hyperplasia of the columnar epithelium of the endocervix. CASE PRESENTATION: We present the case of a giant fibroepithelial polyp measuring approximately 11 x 6 x 4 cm which was protruding from the anterior lip of the uterine cervix in a 51-year-old woman who clinically presented vaginal bleeding. She was nulligravida and doesn’t have a child. The speculum examination revealed a soft, mobile, painless irregular cerebriform mass on the cervix, protruding through the vagina. The polyp was excised using a scalpel, and the pedicle was sutured using the Vicryl 1-0 under short-term intravenous anaesthesia. Histopathological examination revealed a polypoidal tumour mass composed of cellular fibrovascular stroma covered with stratified squamous epithelium. Three months after the initial surgery, there was no recurrence seen. CONCLUSION: Cervical giant polyps are rare entities and occur mostly in perimenopausal women. Transvaginal polypectomy, as performed for this patient followed by histopathological examination is an adequate procedure for these lesions.
Epidemiology of Mesothelioma

Since 1973 the International Agency for Research on Cancer has classified asbestos as a certain carcinogen, but today it is still used in several countries. To date, mesothelioma risk is certainly linked not only to occupational exposures but also to environmental exposures. The incidence and mortality are increasing worldwide, especially in developing countries where asbestos is still often used without adequate measures for worker safety. The epidemiological surveillance systems of related asbestos diseases are instruments of public health adopted internationally. The experience and the operating methodology of the Italian mesothelioma registry and the data produced from 1996 to 2015 highlight how in countries where the asbestos ban has been active for over 20 years the risk of asbestos remains present, especially in the construction sector as well as for the environmental exposures of the resident population near companies that used asbestos in their production cycle. Worldwide, it is necessary to introduce the ban on the extraction, processing, and marketing of asbestos as claimed by the international scientific community.
Oxycodone versus Fentanyl for Intravenous Patient-Controlled Analgesia after Laparoscopic Gynecologic Surgery

Objective: Oxycodone, a semi-synthetic thebaine derivative opioid, is commonly used for treating moderate to severe pain. The aim of this study was to compare the efficacy and side effects of oxycodone and fentanyl used for treating postoperative pain with intravenous patient-controlled analgesia (IV-PCA) after laparoscopic gynecologic surgery. Methods: A total of 122 patients were randomized to receive postoperative pain treatment with either oxycodone (n= 62, group O) or fentanyl (n= 60, group F). Patients received 7.5 mg oxycodone and 150 mcg fentanyl with ketorolac 30 mg at the end of anesthesia, and then continued with IV-PCA (conversion dose ratio, 50:1) for 48 hours postoperatively. A blinded observer assessed postoperative pain based on a numerical rating scale, postoperative nausea and vomiting and other side effects, infused PCA dose, patient satisfaction, and sedation level. Results: No significant differences were observed in patient satisfaction according to the analgesic used during the 48 hours postoperative period. Conclusion: Oxycodone showed similar efficacy for pain relief compared to fentanyl when used at a conversion dose ratio of 50:1. Therefore, oxycodone may be useful as an alternative to fentanyl for IVPCA after laparoscopic gynecologic surgery.
Recurrent Aspiration Pneumonia in a Missed Case of Broncho-Esophageal Fistula with Repaired Esophageal Atresia: Usefulness of Fiberoptic Bronchoscopy: A Case Report

: Broncho-esophageal fistula (BEF) is a rare congenital anomaly affecting the respiratory and upper gastrointestinal tract. The rarity makes its timely diagnosis very challenging. This study presents a rare case of missed congenital BEF in a six-year-old girl with repaired esophageal atresia in the neonatal period suffering from recurrent respiratory symptoms, choking, and respiratory distress following eating, resulting in vomiting or regurgitation for three years before admission. While the contrast esophagography and endoscopy had failed to diagnose her problem, the methylene blue test via an esophageal catheter observed by fiberoptic bronchoscopy could detect the presence of BEF reliably in the present case. Presenting this case can raise physicians’ knowledge of the diagnostic role of methylene blue test via fiberoptic bronchoscopy.
Circulating microRNAs and liquid biopsy: murine xenograft models for technical validation of clinical protocols

In oncology, liquid biopsy is applied to detect with high efficiency clinically relevant analytes, such as tumor cells, cell-free nucleic acids, and exosomes in peripheral blood and other body fluids of cancer patients. Liquid biopsy is considered one of the most advanced non-invasive diagnostic systems useful, in the next future, for enabling personalized treatments in precision medicine. Medical actions include, but are not limited to, early diagnosis, staging, prognosis, anticipation (lead time) and prediction of therapy responses, as well as follow up. Experimental system for validation of the proposed liquid biopsy approaches is highly needed. In this review article we will discuss the establishment of xenotransplanted mouse model systems for the validation of liquid biopsy protocols aimed to identify changes in the miRNA plasma content. Human colon cancer HT-29 and LoVo cells have been xenotransplanted and miR-221-3p and miR-222-3p have been comparatively analyzed in cultured HT-29 and LoVo cells, xenotransplants and plasma samples.
High Hepatitis E virus (HEV) Positivity Among Domestic Pigs and Risk of HEV Infection of Individuals Occupationally Exposed to Pigs and Pork Meat in Hanoi, Vietnam

Abstract Background Hepatitis E virus (HEV) infection can occur through consumption of undercooked pork meat or exposure to animal feces. Because there are scarce data only in developing countries, we assessed whether pigs might be a potential source of human HEV infections in Vietnam. In addition, we determined anti-HEV seroprevalences in the general population and in individuals professionally exposed to pigs and pork meat. Methods The study took place in Hanoi, Vietnam. Liver tissues from domestic pigs (n = 210) and serum samples obtained from individuals occupationally exposed to pigs and pork meat (n = 283) and from unexposed healthy controls (n = 168) were screened for HEV-ribonucleic acid (RNA) by reverse-transcription polymerase chain reaction. The exposed group was divided into pork meat vendors (n = 81), pig farmers (n = 96), and slaughterers (n = 106). Serum samples were subjected to HEV immunoglobulin (Ig)G and IgM enzyme-linked immunosorbent assays. The HEV genotypes were assessed by direct sequencing, followed by phylogenetic analyses. Results Hepatitis E virus seroprevalence was higher among persons occupationally exposed to pigs/pork meat compared with unexposed individuals (anti-HEV IgM 11% vs 6%, P = .07; anti-HEV IgG 53% vs 31%, P < .0001). Positivity of anti-HEV IgG among slaughterhouse staff was 66%, followed by 51% in pig-farmers and 38% in pork meat vendors (P = .00073). A similar trend was observed for IgM positivity. Of the pig liver tissues, 26 of 210 (12.4%) were positive for HEV-RNA and assessed to be HEV genotype 3. Conclusions Hepatitis E virus circulates in domestic pigs in Hanoi and constitutes a permanent zoonotic disease risk. The high HEV seroprevalence among occupationally exposed individuals indicates an associated risk of HEV infection.
Maize-crotalaria intercropping systems

The objective of this study was to identify a maize-crotalaria intercropping system feasible for producing straw while maintaining maize yield. A study with a completely randomized block design was performed in 2015 and 2016, with 7 × 2 + 1 split plot and three replications in a clayey Red Oxisol. Seven intercropping systems were allocated to each plot, and two crotalaria species (Crotalaria spectabilis and C. ochroleuca) cultivated with maize in monoculture were allocated to each subplot. Crotalaria yield, total chlorophyll content, nitrogen content, plant height, plant dry matter, thousand grain mass, and corn grain yield were evaluated. C. spectabilis was more sensitive to water level variations during the crop cycle than C. ochroleuca. Crotalaria sown before maize planting with maize seeds incorporated in the soil presented a relatively higher phytomass but decreased corn grain yield. The management system in which crotalaria was sown in the inter-row with a ridge planter at the time of maize planting and the system in which crotalaria was sown in the maize sowing furrow were feasible for straw production because they did not decrease corn grain yield and did not affect maize harvesting operations.