Miracle-dz/UniFAR-FTUs huggingface dataset:
A case of silent colonic lesions associated with streptococcus gallolyticus, bacteremia and endocarditis

We present a clinical case of synchronous colonic lesions, histologically different, associated with streptococcus gallolyticus subsp. gallolyticus (Sgg)/ Streptococcus bovis biotype I, bacteremia and infective endocarditis. A 53-year-old female, without history of CRC in her family, known with total hysterectomy for uterine fibromatosis, presents to Emergency Department for marked asthenia, nausea, weight loss (10 kgs in the last month), febrile episode associated with severe anemia, symptomatology that has increased in the last two weeks. The patient was admitted in the Internal Medicine Department for further investigations, under the suspicion of sepsis of unknown cause. On blood cultures grew Sgg bacteria. Both transthoracic echocardiography and transesophageal echocardiography were performed and diagnosed infective endocarditis with vegetations of the mitral and aortic valves. Antibiotics treatment was initiated, with ceftriaxone and gentamycin, according to antibiogram results. Severe hypochromic, microcytic anemia, and lack of an infective origin site required digestive endoscopic evaluation, and showed gastritis, ulcerovegetative tumor of the ascending colon and polyp in the rectosigmoid. Resection of rectosigmoid polyp was performed through colonoscopy, and, also, right hemicolectomy with ileo-transverse anastomosis for the ascending colon cancer. Post-operative evolution was favorable. Histological result showed mucinous adenocarcinoma of the ascending colon and tubulovillous adenoma, with moderate dysplasia, in the rectosigmoid. At 6-month, endoscopic evaluation showed normal aspect of anastomosis without presence of other colonic lesions.
Pronunciation Myths: Applying Second Language Research to Classroom Teaching

This volume was conceived as a "best practices" resource for pronunciation and speaking teachers in the way that "Vocabulary Myths" by Keith S. Folse is one for reading and vocabulary teachers. Like others in the "Myths "series, this book combines research with good pedagogical practices.The book opens with a Prologue by Linda Grant (author of the "Well Said "textbook series), which reviews the last four decades of pronunciation teaching, the differences between accent and intelligibility, the rudiments of the English sound system, and other factors related to the ways that pronunciation is learned and taught.The myths challenged in this book are: Once you ve been speaking a second language for years, it s too late to change your pronunciation. (Derwing and Munro) Pronunciation instruction is not appropriate for beginning-level learners. (Zielinski and Yates) Pronunciation teaching has to establish in the minds of language learners a set of distinct consonant and vowel sounds. (Field) Intonation is hard to teach. (Gilbert) Students would make better progress if they just practiced more. (Grant) Accent reduction and pronunciation instruction are the same thing. (Thomson) Teacher training programs provide adequate preparation in how to teach pronunciation (Murphy). The book concludes with an Epilogue by Donna M.Brinton, who synthesizes some of the best practices explored in the volume. "
Avaliação da atenção em diabetes mellitus em uma unidade básica distrital de saúde

The objective of this cross-sectional quantitative study is to evaluate the structure and process components in Diabetes Mellitus user care given in a Basic Health District of Ribeirao Preto, SP, Brazil. We analyzed 138 medical records from users with Diabetes Mellitus in 2008. As a methodological reference, we used the Health Care Assessment using structure and process as the cut. A questionnaire containing 24 closed questions was used to collect data. Concerning the structure, the results showed that physical and material resources were adequate. As for the process, the actions implemented in assisting users with Diabetes Mellitus were fragmented. It follows that we must rethink the way such work is organized, helping health actions become committed to a fair quality practice, which promotes communication among the various professionals involved in Diabetes care and full compliance with their duties and responsibilities DESCRIPTORS: Health evaluation. Diabetes mellitus. Nursing. Human resources.
Pharmacokinetic/pharmacodynamic relationship of pulmonary administration methods for milrinone : a translational approach

127 Introduction . 128 Material and Methods. 130 Results and Discussion . 135 Conclusion . 138 Tables . 139 Figures . 141 References . 145 CHAPTER 11. Manuscript #3: Use of nebulized milrinone in cardiac surgery; Comparison of vibrating mesh and simple jet nebulizers. 148 Abstract . 149 Introduction . 150 Material and methods. 152 Results . 160 Discussion . 163 Conclusion . 170 Tables . 171 Figures . 173 References . 178. 149 Introduction . 150 Material and methods. 152 Results . 160 Discussion . 163 Conclusion . 170 Tables . 171 Figures . 173 References . 178
Interleukin‐4 and interferon‐gamma production in atopic and non‐atopic children with ashma

Previous studies have demonstrated increased production of interleukin‐4 (IL‐4) and reduced production of interferon (IFN)‐γ in stimulated peripheral blood mononuclear cell cultures from children and adults with atopic dermatitis, however, it is unclear whether such an imbalance of cytokine production relates to other childhood atopic diseases such as asthma, and in particular to the presence of the atopic state per se. The production of IL‐4 and IFNγ in phytohaemagglutin‐ (PHA)‐stimulated peripheral blood mononuclear cell (PBMC) cultures from atopic and non‐atopic children with moderately severe chronic persistent asthma, and a group of age‐matched non‐atopic controls who did not have asthma was examined. Atopic children with asthma produced significantly more IL‐4 and less IFNγ than non‐atopic children with asthma and non‐atopic controls who did not have asthma. There was no significant difference in IL‐4 or IFNγ production between non‐atopic children with asthma and controls. These findir. 3 demonstrate that an imbalance of IL‐4 and IFNγ production is present in atopic asthma as previously documented in atopic dermatitis, therefore suggesting that it is a feature of the atopic state per se.
The true absorption of cyst(e)ine from the ovine small intestine

1. Na234SO4 was infused into the rumen of a sheep fed a dried grass diet. 2. The digesta at the pylorus which contained 35S-labelled cyst(e)ine synthesized by the rumen microflora was collected and mixed with chromium EDTA. This material was infused into the duodenum of 35S free sheep. 3. Ileal digesta was subsequently collected and analysed for cyst(e)ine 35S and Cr. 4. The proportion of the labelled cyst(e)ine truly absorbed from the small intestine was 0.72±0.004.
A Versatile Program for the Analysis of Electromyographic Data

Ergonomists and researchers often utilize electromyographic (EMG) recordings to produce estimates of muscular work load in occupational exposure assessment. Prolonged measurements, possible with recent technological advances in portable data acquisition and compact memory storage technologies, require efficient data reduction methods not always available in commercial software packages. The Iowa EMG Analysis Program (IEAP) was created to provide researchers the means to incorporate multiple processing techniques suited for the analysis of prolonged EMG measurements. IEAP currently includes subroutines to calculate the amplitude probability distribution function, exposure variation analysis, clustered exposure variation analysis, and gaps analysis profiles for up to four channels of root-mean-square processed EMG data. Data management functions include the creation of customized hypertext markup language (HTML) documentation and text files able to seamlessly incorporate analysis results into existing statistical software packages. IEAP is a powerful EMG analysis tool ideally suited for ergonomists and researchers involved in occupational ergonomics studies.
The effects of general anaesthesia on memory recall following day-case knee arthroscopy

Declaration: The authors would like to declare that this study has not been published or being reviewed by other journals. Retention of new information may be impaired during recovery from general anaesthesia. Patients are likely to be anxious if they cannot recall information conveyed at the surgeons’ postoperative visit. Previous studies have shown evidence of short-term memory impairment after GA. Patients undergoing day case knee arthroscopy under general anaesthesia were told five random words and three diagnostic findings from their operation, by the surgeon prior to discharge. The patients were telephoned the following day to test their recall of words and diagnostic findings, with a maximum possible score of eight. 96 patients were available for the telephone follow-up. The patients were grouped according to the interval between the end of anaesthesia and the time the information was given to them. For knee arthroscopy day cases it appears that, allowing as much time as possible after anaesthesia, at least two hours if possible, before reviewing a patient in the recovery area will likely enhance his/her later recall of the clinical information, potentially setting patient expectations at the appropriate level and improving compliance with postoperative rehabilitation. For the surgeons’ post-operative visit to be valuable to the patient, it should take place at least two hours following cessation of anaesthesia. It is advisable to endorse verbal communication with written information.
Evaluation of autism education trust training hubs programme : interim report - results from the L2 and L3 pilot training sessions and views of hub leads

The Autism Education Trust’s (AET) training hubs programme comprises the development and delivery of three levels of training (Level 1 awareness raising; Level 2 for individual staff working with pupils with autism; Level 3 for those in leadership roles able to influence whole school practices), as well as the development and roll-out of national Standards and a Competency Framework. This Interim Report focuses on results from the Level 2 (L2) and Level 3 (L3) pilot training sessions (to end September 2012), as well as presenting the views of the seven hub leads on the AET Programme as a whole. It follows earlier reports of the Level 1 training sessions to end June 2012.
Catchment dynamics and social response during flash floods: the potential of radar rainfall monitoring for warning procedures

The objective of this paper is to examine how current techniques for flash‐flood monitoring and forecasting can meet the needs of the population at risk to evaluate the flood severity and anticipate its danger. To this end, the social response time for different social actions in the course of two well studied flash flood events which occurred in France and Italy is identified. The event management activities are broadly characterized into three types according to their main objective (information, organisation and protection). The activities are also classified into three other types according to the scale and nature of the human group involved (individuals, communities and institutions). The conclusions reached relate to (1) the characterisation of the social responses according to watershed scale and to the information available, and (2) to the appropriateness of the existing surveillance and forecasting tools to support the social responses. Results suggest that representing the dynamics of the social response with just one number representing the average time for warning a population is an oversimplification. It appears that the social response time exhibits a parallel with the hydrological response time, by diminishing in time with decreasing size of the relevant watershed. A second result is that the human groups have different capabilities of anticipation, apparently based on the nature of information they use. Comparing watershed response times and social response times shows clearly that at scales of less than 100 km2, a number of actions were taken with response times comparable to the catchment response time. The implications for adapting the warning processes to social scales (individual or organisational scales) are considerable. At small scales, and for the implied anticipation times, the reliable and high‐resolution description of the actual rainfall field becomes the major source of information for decision‐making processes such as deciding between evacuations or advising to stay home. This points to the need to improve the accuracy and quality control of real time radar rainfall data, especially for extreme flash flood‐generating storms. Copyright © 2009 Royal Meteorological Society
Comparison of Digitized Images for Cephalometric Analysis from Scanner and Digital Cameras

Objective: The aim of the study was to compare the manual tracing of lateral cephalometric radiographs with the use of cephalometric software obtained by 2 methods: use of a scanner and use of cameras to test the accuracy of measurement for clinical orthodontic diagnosis. Material and Methods: The original method of manual tracing was compared to 2 radiographic digitization methods: A) captured from a scanner, B) captured from digital cameras applied to 40 randomly selected cephalograms of orthodontic patients at Mahidol University. The digital images from cameras and scanner were analyzed with image processing software (CephSmile). The repeatability test was obtained for all methods, and the paired t-test determined the statistical significance between digitized images and original manual tracings for thirty-four measurements. Results: The paired t-test showed no significant differences among all 34 variables. Most mean differences were less than 0.25 mm and 0.25 degrees. Conclusion: The results demonstrated that there were no significant differences on measurement parameters for cephalometric analysis among manual tracing and computerized digital images from scanner and cameras.
A Profile of Central Corneal Thickness (CCT) in Primary Open Angle Glaucoma in Trinidad and Tobago and the Implications

INTRODUCTION It is well documented that both the prevalence and progression of glaucoma have greater tendencies in patients of Caribbean Descent (1, 2). Primary open angle glaucoma (POAG) occurs 10 years earlier, progresses faster and treatment modalities are less efficacious in our ethnicity (1). Thin corneas have been demonstrated as a strong independent predictor for the development of glaucomatous optic neuropathy following multivariate analysis (3, 4). The risk of developing POAG doubled for every 40 μm decrease in central corneal thickness (CCT) from the overall mean of 573.3 μm (5, 6). The aim of the study was to profile the central corneal thickness within our patient population, assess the risk and outline the implications.
Prevalence Of Thrombophilic Mutations In Ischemic Stroke Patients In Isparta, Turkey

Ad dress for Cor res pon den ce/Ya z›fl ma Ad re si: Nilgün Erten MD, Giresun University Faculty of Medicine, Department of Neurology, Giresun, Turkey Phone: +90 454 310 10 00 E-mail: nderten@hotmail.com Re cei ved/Ge lifl Ta ri hi: 01.09. 2014 Ac cep ted/Ka bul Ta ri hi: 11.03. 2015 Objective: The present study aimed to investigate whether the frequency of factor V, methylenetetrahydrofolate reductase (MTHFR), prothrombin, β-fibrinogen gene mutations, and human platelet alloantigens (HPA), plasminogen activator inhibitor 1 (PAI1), apolipoprotein E (APOE), and angiotensin converting enzyme (ACE) gene polymorphisms in stroke patients is higher than that in normal individuals. Materials and Methods: Two hundred twelve patients with cerebral infarction and 238 individuals of similar age and gender with no history of stroke were included. Demographics and risk factors for cerebrovascular disease of all individuals were determined. Biochemical parameters were analyzed in serum, and electrocardiography was performed. Factor V, MTHFR, prothrombin, β-fibrinogen mutations and HPA, PAI, APOE, and ACE polymorphisms were investigated. Data were analyzed with SPSS 15.0 software using descriptive statistics, chi-square, independent two-group t-test, and logistic regression tests. Statistically significant differences in independent variables were further analyzed by logistic regression. Results: HPA, PAI, APO, and ACE polymorphism frequency was not significantly different between the stroke and control groups. Factor V H1299R, factor V Leiden, and β fibrinogen -455GA mutation frequencies were significantly higher in the stroke than the control group in the chi-square test, but not in logistic regression analysis. Conclusion: Stroke etiopathogenesis is multifactorial, and prothrombin gene mutations increase the impact of existing risk factors when other risk factors are considered. (Turkish Journal of Neurology 2015; 21:42-8)
Predictive role of plasmatic biomarkers in advanced non-small cell lung cancer (NSCLC) treated with nivolumab (nivo).

Background: Nivolumab (nivo) is an anti-PD1 antibody, used in second line treatment in non-small cell lung cancer (NSCLC). We investigated the potential interest of immune-related blood markers in patients with advanced NSCLC treated with nivo. Patients and methods: Plasma samples of 43 consecutive patients were prospectively collected at the time of diagnosis of cancer, at the initiation of nivo and at the first tumour evaluation (2 months). Concentrations of soluble PD-L1 (sPD-L1), soluble PD-L2 (sPD-L2), Interleukine-2 (Il-2), Interferon-gamma (IFN-γ), and Granzyme B (GranB) were quantified by ELISA. Plasmatic miRNA screening was also performed at the initiation of nivo. Expression of PD-L1 on tumour biopsies was evaluated by immunohistochemistry (IHC) using E13LN. Tumour response was evaluated by iRECIST. Results: High sPD-L1 at 2 months and increase of sPD-L1 concentrations at the beginning of nivo treatment were associated with poor response and tumour progression within 6 months of treatment. sPD-L1 concentrations at diagnosis were not correlated with PD-L1 expression on corresponding tumour samples. Low GranB at nivo initiation was also associated with poor response. High sPD-L1 and low GranB were associated with poor progression-free survival (PFS) and overall survival (OS). Low sPD-L2, low Il-2 and high IFN-γ were associated with grade 3-4 toxicities. miRNA screening showed that patients with long-term clinical benefit (n=9) had down-expression of miRNA-320b and -375 compared to patients with early progression at 2 months (n=9). Conclusion: Our results showed the predictive value of circulating biomarkers in patients with NSCLC treated with nivo.
Dead Ringer? Visitors' Understanding of Taxidermy as Authentic and Educational Museum Exhibits

ABSTRACT Museum professionals value authentic museum specimens because they are believed to promote inspirational and educational experiences for visitors; however, limited research has tested whether visitors value museum specimens in these ways. In this study, 4- to 10-year-olds and adults (n = 228), who were visiting the Oxford University Museum of Natural History, were asked to explain whether a taxidermied rabbit belonged in a museum and could help museum visitors learn about rabbits. Participants responded about a taxidermied rabbit that was presented either as a touchable object, inside an exhibition case, or alongside a realistic soft toy rabbit because this was expected to provide a useful context to support children's responses. As expected, the number of visitors who thought that the taxidermied rabbit belonged in a museum and could help visitors learn about rabbits increased with age and was greater when it was presented alongside the toy rabbit. Visitors explained their decisions by referring to the stillness of the taxidermied animal that permitted detailed study, its authentic features, and its previous status as a living animal. Implications for promoting visitors' understanding of taxidermy are discussed.
Older African American Men’s Perspectives on Factors That Influence Type 2 Diabetes Self-Management and Peer-Led Interventions

Older African American men are at increased risk of Type 2 Diabetes (T2D) but demonstrate high rates of poor illness management. They also participate in interventions targeting illness management at extremely low rates and are at high risk for dropout from clinical trials. One modifiable factor that has been identified in the literature that contributes to these disparities is health beliefs particular to men. Yet, despite the fact that illness management interventions have been developed to meet the needs of African Americans, none have followed recommendations to use gender-sensitive programming to meet the needs of men. The primary aim of this study was to advance our understanding of the intersection of age, race/ethnicity and gender on T2D self-management among older African American men, and to explore their preferences for a peer-led T2D self-management intervention. Two focus groups were conducted with older African American men (n = 12) over a 6-month period. Sessions lasted 90 min, were audiotaped, and analyzed using thematic content analysis techniques. The most prominent themes included: (a) the influence of gendered values and beliefs on health behavior; (b) quantity and quality of patient-provider communication; (c) social and structural barriers to T2D self-management; and (d) preferences for peer-led T2D self-management interventions. Results suggest that these themes may be particularly salient for T2D self-management in older African American men, and that this population may be receptive to a peer-led T2D self-management intervention.
THYROID DYSFUNCTION IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AT TERTIARY CARE CENTRE

Background: The aim of the present study was to find the prevalence of thyroid dysfunction in patients with type 2 diabetes mellitus (type 2 DM) attending an outpatients department and medical wards in Dr D Y Patil Medical College and Hospital. Materials and Methods: Data of 50 diabetic and 50 non diabetic patients who attended OPD and admitted in medical wards of Dr D Y Patil Medical College and Hospital, pimpri, pune from September 2012 to September 2013. These subjects were investigated for total triidothyronine (T3), total thyroxin (T4), thyroid stimulating hormone (TSH), Fasting Blood Sugar(FBS), glycosylated hemoglobin (HbA1c), serum cholesterol, serum triglycerides, high density lipoprotein(HDL), low densit lipoprotein(LDL), very low density lipoprotein(VLDL), blood urea, serum creatinine. Results: The level of T3and T4were significantly lower while the level of TSH was significantly higher in type 2 diabetics as compared to non-diabetics. From the 50diabetic subjects studied, 30% showed abnormal thyroid hormone levels (22 % had hypothyroidism and 8 % had hyperthyroidism). Significantly higher levels of FPG, HbA1c, serum cholesterol, serum triglyceride, LDL, VLDL, blood urea, creatinine, and significantly lower level of HDL was observed in diabetics as compared to non-diabetics subjects. Conclusion: The prevalence of thyroid dysfunction among type 2 DM patients is very high (30 %) with subclinical hypothyroidism is being most common. All patients with type 2 DM should be screened for thyroid dysfunction to reduce the mortality rate.
Peer Comment: Films, digs and death: a review of the Project Eliseg videos

In this review I evaluate the article by Tong et al. on the use of video of archaeological fieldwork during the Project Eliseg excavations. To understand the context of this study, I briefly survey how video is discussed by archaeologists in blog posts, conference presentations and scholarly articles. I then assess the aims, structure, content and technique of the videos produced by Project Eliseg. Finally, I analyse the strengths and weaknesses of their use of video using a model of public engagement.