Miracle-dz/UniFAR-FTUs huggingface dataset:
Feature selection using genetic algorithms for fetal heart rate analysis

The fetal heart rate (FHR) is monitored on a paper strip (cardiotocogram) during labour to assess fetal health. If necessary, clinicians can intervene and assist with a prompt delivery of the baby. Data-driven computerized FHR analysis could help clinicians in the decision-making process. However, selecting the best computerized FHR features that relate to labour outcome is a pressing research problem. The objective of this study is to apply genetic algorithms (GA) as a feature selection method to select the best feature subset from 64 FHR features and to integrate these best features to recognize unfavourable FHR patterns. The GA was trained on 404 cases and tested on 106 cases (both balanced datasets) using three classifiers, respectively. Regularization methods and backward selection were used to optimize the GA. Reasonable classification performance is shown on the testing set for the best feature subset (Cohen's kappa values of 0.45 to 0.49 using different classifiers). This is, to our knowledge, the first time that a feature selection method for FHR analysis has been developed on a database of this size. This study indicates that different FHR features, when integrated, can show good performance in predicting labour outcome. It also gives the importance of each feature, which will be a valuable reference point for further studies.
Blood Pressure Variability and Organ Damage in a General Population: Results from the PAMELA Study

In hypertensive patients, 24-hour blood pressure (BP) variability (V) shows a positive relationship with organ damage, organ damage progression, and cardiovascular morbidity. The clinical relevance of BPV in the population has never been investigated. In a sample of 3200 individuals, randomly selected from the general population of Monza (Milan, Italy), we evaluated BP by an automatic oscillometric device every 20 minutes for 24 hours and left ventricular mass index (LVMI) by echocardiography. In each subject, individual systolic and diastolic BP readings were averaged to obtain a 24-hour mean. Systolic BPV was obtained by calculating (1) the standard deviation of the 24-hour mean, which was taken as the overall BPV, (2) the cyclic components (Fourier spectral analysis) that in the population as a whole explained >95% of the overall BPV, and (3) the fraction of the overall BPV that in each subject was not accounted for by the 2 cyclic components, termed individual residual BPV. A similar procedure was used for diastolic BP and heart rate. Participation rate was 64.1%. Patients receiving antihypertensive therapy (n=403) were excluded from the analysis, which was therefore limited to 1648 participants. In the population as a whole, LVMI significantly related to 24-hour systolic and diastolic BP mean (&bgr;=0.40 and &bgr;=0.37, respectively, P <0.001 for both) but not to the 2 cyclic components that accounted for most of the BPV. On the other hand, the individual residual BPV (which accounts on average for about 50% of overall BPV) showed a significant positive relationship with LVMI (&bgr; =0.38 and &bgr;=0.88 for systolic and diastolic BP, respectively, P <0.05 and P <0.01). No relationship was found between LVMI and heart rate values. These findings provide evidence that there is a relationship between LVMI and 24-hour average BP values in the population. They also provide the first demonstration that in the population there is also a positive independent association between LVMI and BPV. This association, however, can be exclusively seen with the BPV component that has an erratic rather than a cyclic nature.
A Potential Role for Human Cohesin in Mitotic Spindle Aster Assembly*

The cohesin multiprotein complex containing SMC1, SMC3, Scc3 (SA), and Scc1 (Rad21) is required for sister chromatid cohesion in eukaryotes. Although metazoan cohesin associates with chromosomes and was shown to function in the establishment of sister chromatid cohesion during interphase, the majority of cohesin was found to be off chromosomes and reside in the cytoplasm in metaphase. Despite its dissociation from chromosomes, however, microinjection of an antibody against human SMC1 led to disorganization of the metaphase plate and cell cycle arrest, indicating that human cohesin still plays an important role in metaphase. To address the mitotic function of human cohesin, the subcellular localization of cohesin components was reexamined in human cells. Interestingly, we found that cohesin localizes to the spindle poles during mitosis and interacts with NuMA, a spindle pole-associated factor required for mitotic spindle organization. The interaction with NuMA persists during interphase. Similar to NuMA, a significant amount of cohesin was found to associate with the nuclear matrix. Furthermore, in the absence of cohesin, mitotic spindle asters failed to form in vitro. Our results raise the intriguing possibility that in addition to its well demonstrated function in sister chromatid cohesion, cohesin may be involved in spindle assembly during mitosis.
Right prefrontal cortex transcranial direct current stimulation enhances multi-day savings in sensorimotor adaptation.

We have previously reported that visuospatial working memory performance and magnitude of activation in the right dorsolateral prefrontal cortex predict the rate of visuomotor adaptation. Recent behavioral studies suggest that sensorimotor savings, or faster relearning on second exposure to a task, are due to recall of these early, strategic components of adaptation. In the present study we applied anodal transcranial direct current stimulation to right or left prefrontal cortex or left motor cortex. We found that all groups adapted dart throwing movements while wearing prism lenses at the same rate as subjects receiving sham stimulation on day 1 On test day 2, which was conducted a few days later, the right prefrontal and left motor cortex groups adapted faster than the sham group. Moreover, only the right prefrontal group exhibited greater savings, expressed as a greater difference between day 1 and day 2 errors, compared with sham stimulation. These findings support the hypothesis that the right prefrontal cortex contributes to sensorimotor adaptation and savings. NEW & NOTEWORTHY We have previously reported that visuospatial working memory performance and magnitude of activation in the right dorsolateral prefrontal cortex predict the rate of manual visuomotor adaptation. Sensorimotor savings, or faster adaptation to a previously experienced perturbation, has been recently linked to cognitive processes. We show that facilitating the right prefrontal cortex with anodal transcranial direct current stimulation enhances sensorimotor savings compared with sham stimulation.
The coxibs, selective inhibitors of cyclooxygenase-2.

Nonsteroidal antiinflammatory drugs (NSAIDs) are widely used to treat arthritis, menstrual pain, and headache. Although they are effective, their long-term use is limited by gastrointestinal effects such as dyspepsia and abdominal pain and, less often, gastric or duodenal perforation or bleeding. Development of the coxibs, a new group of antiinflammatory drugs, represents a response to the unsatisfactory therapeutic profile of NSAIDs. Both groups of drugs inhibit prostaglandin G/H synthase, the enzyme that catalyzes the transformation of arachidonic acid to a range of lipid mediators, termed prostaglandins and thromboxanes (Figure 1). However, whereas NSAIDs inhibit the two recognized forms of the .
Managing commitment in the personal care service industry: the special case of hairdressing services

Since its inception, the concept of customer commitment has been extensively researched, especially in the field of relationship marketing. It is therefore not surprising to find that the concept of commitment has been applied to various industries, both on an academic and practical level. However, the same cannot be said about the personal care service industry, which refers to industries that are characterised by high levels of customer interaction during the service delivery process. These industries include the hairdressing, legal services and medical services industries. This study focuses on the management of customer commitment from a personal care service perspective. The specific context of the study is the hairdressing industry. The study applies Meyer and Allen? s well-documented three-component model of commitment, and investigates the management of affective, calculative and normative commitment in the hairdressing industry. A quantitative approach was used to analyse the perceptions of 270 Generation Y respondents. Generation Y, also known as the millennials, refers to people who were born in the 1980s and 1990s. The data were analysed in SPSS version 25, and a regression analysis was used to assess the statistical significance of the hypothesised relationships. The results of the study indicate that satisfaction, social bonds, attractiveness of alternatives, relationship benefits and communication are significant antecedents of customer commitment in the hairdressing industry. The primary contribution of the study lies in the fact that it provides both theoretical insights and practical recommendations on how customer commitment in this relatively under-researched context should be managed.
Transfusion-Related Acute Lung Injury: Current Concepts for the Clinician

The leading cause of transfusion-related morbidity and mortality in the United States is transfusion-related acute lung injury (TRALI). Diagnostic criteria for TRALI have recently been developed and primarily consist of hypoxia and bilateral pulmonary edema occurring during or within 6 h of a transfusion in the absence of cardiac failure or intravascular volume overload. The primary differential diagnosis is transfusion-associated circulatory overload and differentiation can be difficult. Treatment is supportive with oxygen and mechanical ventilation. Diuresis is not indicated and the role of steroids is unproven. Patients typically recover within a few days. All types of blood products have been associated with TRALI, however, the plasma-rich components, such as fresh frozen plasma and apheresis platelets, have been most frequently implicated. The pathogenesis of TRALI is not completely understood. Leukocyte antibodies in donor plasma have been implicated in most cases with antibodies directed at human leukocyte antigen (HLA) class I, HLA class II or neutrophil-specific antigens, particularly HNA-3a. Activation of pulmonary endothelium is important in the development of TRALI and may account for most cases being observed in surgical or intensive care unit patients. Transfused leukoagglutinating antibodies bind to recipients’ neutrophils localized to pulmonary endothelium resulting in activation and release of oxidases and other damaging biologic response modifiers that cause capillary leak. In a minority of TRALI cases, no antibodies are identified and it is postulated that neutrophil priming factors in the transfused component can mediate TRALI in a patient with pulmonary endothelial activation, the so called “two hit” mechanism. Recognition of the role of anti-leukocyte antibodies has led to new strategies to reduce the risk of TRALI. Female blood donors with a previous pregnancy frequently have HLA antibodies with an overall prevalence of 24% and increasing prevalence related to the number of previous pregnancies. Since HLA antibodies have been implicated in TRALI, blood centers have adopted policies to produce plasma components primarily from male donors. Strategies to reduce the risk from apheresis platelets are problematic and are likely to involve testing female apheresis platelet donors for HLA antibodies. Much more research is needed to understand the blood component and patient risk factors for TRALI so that novel strategies for treatment and additional measures to reduce the risk of TRALI can be developed.
Blood pressure–controlling behavior in relation to educational level and economic status among hypertensive women in Ghana

Objective To explore the association between economic status and educational level with self-management behavior (medication adherence, controlling body weight, reducing salt intake, performing physical exercise, reducing alcohol consumption, abstaining from smoking, increasing fruit and vegetable consumption) among hypertensive women in Ghana. Methods Cross-sectional data on 598 women were collected from the Ghana Demographic and Health Survey of 2014. The association between economic status and educational level with self-management behavior was measured by logistic regression methods. Results Mean systolic blood pressure and diastolic blood pressure were 131.4 and 86.58 mm Hg, respectively. With regard to self-management behavior, 81.8% of women reported taking medication to control high blood pressure, 44.4% reported controlling body weight, 22.5% reported reducing salt intake, 48.3% reported performing physical exercise, 74.2% reported reducing alcohol consumption, 74.2% reported abstaining from alcohol and smoking, and 20.2% reported consuming more fruits and vegetables. Women living in the wealthiest households had significantly higher odds of maintaining healthy weight, reducing salt intake, and exercising. Conclusion The findings imply that socioeconomic factors may play important roles in women’s adherence to blood pressure–controlling behavior. It is therefore suggested that policy makers focus on improving women’s economic status as a strategy to encourage cardiovascular health–promoting behavior. Significance statement This is the first study to assess the effect of socioeconomic status on blood pressure–controlling behavior among adult women with hypertension in Ghana. The findings could be of crucial importance to health and social policy makers who are working toward reducing the burden of heart diseases and promoting healthy behavior among adult women in Ghana as well as in neighboring countries.
Conceptual Framework of Corporate Culture Influenced on Employees Commitment to Organization

Based on analyzing to some previous research, this study is developed by using constructs to explain how the dimension of corporate culture impacts employees commitment. This study uses examination model based on the literature reviews of previous research and then the hypotheses were be expended as a methodology. The result of the study shows that the employee commitment to organization can be improved through corporate culture that consists of teamwork, communication, training development and reward-recognition. To maintain efficiency, effectivity and organization productivity could be conducted by optimizing employee commitment to organization by creating and implementing corporate culture consistently. The concept of employee commitment to organization is described with causal relation toward corporate culture which is decomposed into the dimension of teamwork, communication, training development and reward-recognition.
Somatosensory areas engaged during discrimination of steady pressure, spring strength, and kinesthesia

The aim of this study was to locate neuronal populations in the somatosensory areas engaged during discrimination of differences in: (1) static sustained pressure on the distal phalanx (PRESS); (2) spring strengths (SSTIFF) during active flexion of the right index finger; and (3) the change in position of a limb with contracting muscles, i.e., kinesthesia (KIN), during active flexion of the right index finger. The stimuli used were spring‐loaded cylinders. The regional cerebral blood flow (rCBF) was measured with positron emission tomography (PET). The active fields were related to cytoarchitectonic areas of the somatosensory cortex (areas 3a, 3b, 1, and 2) and the primary motor cortex (areas 4a and 4p). We hypothesized that SSTIFF and KIN would activate areas 3a and 2. All three conditions, when contrasted against a rest condition, activated cytoarchitectural areas 3b, 1, and 2, and presumptive somatosensory areas in the left parietal operculum and right supramarginal gyrus in accordance with these areas receiving information from cutaneous mechanoreceptive afferents. Area 3a was only activated in SSTIFF and KIN, consistent with observations in monkeys and cats, showing that afferents from muscle receptors project to area 3a, and indicating that a similar arrangement seems to be apparent in humans. SSTIFF and KIN activated the right anterior lobe of the cerebellum, the left area 4a and left area 2 more than did PRESS, likely due to a combination of active movements and muscle receptor feed‐back. Hum. Brain Mapp. 20:103–115, 2003. © 2003 Wiley‐Liss, Inc.
The use of piezoelectric ceramics for electric power generation within orthopedic implants

This paper presents the results of tests that demonstrate the feasibility of using piezoelectric (PZT) ceramics to generate in vivo electrical energy for orthopedic implants. Sensors encapsulated within implants could provide in vivo diagnostic capabilities such as the monitoring of implant duty (i.e., walking) cycle, detecting abnormally asymmetric or high forces, sensing misalignment and early loosening, and early detection of wear. Early diagnosis of abnormalities or impending failure is critical to minimize patient harm. However, the routine use of sensors and microprocessors embedded within orthopedic implants for diagnostic and monitoring purposes has been limited by the lack of a long-term self-contained power source capable of lasting the expected 20-year implant lifetimes. By embedding PZT materials within orthopedic implants, a small amount of the mechanical energy generated during normal physical activity can be converted into useful electrical energy. This in vivo energy source can power embedded microprocessors and sensors for a broad range of biomedical uses. The current work investigates the application of this technology to total knee replacement (TKR) implants, but it is applicable to many other implanted biomedical devices.
The National Site Licensing of Electronic Resources: An Institutional Perspective

While academic libraries in most countries are struggling to negotiate with publishers and vendors individually or collaboratively via consortia, a few countries have experimented with a different model, national site licensing (NSL). Because NSL often involves government and large-scale collaboration, it has the potential to solve many problems in the complex licensing world. However, not many nations have adopted it. This study uses historical research approach and the comparative case study research method to explore the seemingly low level of adoption. The cases include the Canadian National Site Licensing Project (CNSLP), the United Kingdom’s National Electronic Site Licensing Initiative (NESLI), and the United States, which has not adopted NSL. The theoretical framework guiding the research design and data collection is W. Richard Scott's institutional theory, which utilizes three supporting pillars-regulative, normative, and cultural-cognitive-to analyze institutional processes. In this study, the regulative pillar and the normative pillar of NSL adoption-an institutional construction and change-are examined. Data were collected from monographs, research articles, government documents, and relevant websites. Based on the analysis of these cases, a preliminary model is proposed for the adoption of NSL. The factors that support a country's adoption of NSL include the need for new institutions, a centralized educational policy-making system and funding system, supportive political trends, and the tradition of cooperation. The factors that may prevent a country from adopting NSL include decentralized educational policy and funding, diversity and the large number of institutions, the concern for the ”Big Deal,” and the concern for monopoly.
A Comparative Study of Financial Literacy and Financial Needs of Unbanked and Under Banked Population

This paper assumes an estimation of economical research of rapidly improving body on financial literacy. We begin with a synopsis of academic research, which emit financial learning as a structure interest in human capital. Development of financial learning has significant implication for benefit; also policies planned to increase levels of financial information in the well-built inhabitants. After that, we depict on topical surveys to ascertain how many numbers of people knows and categorize the least financial aptitude population subgroups. Though the narrative is still undeveloped, conclusions may perhaps strain on the subject of the effects and consequences of financial illiteracy, to work for answering these research gaps. A concluding part suggests a view on what remains to be educated, if researchers are to be improved to inform academic and experimental models with public policy.
Short Androgen Suppression and Radiation Dose Escalation for Intermediate- and High-Risk Localized Prostate Cancer: Results of EORTC Trial 22991.

PURPOSE Up to 30% of patients who undergo radiation for intermediate- or high-risk localized prostate cancer relapse biochemically within 5 years. We assessed if biochemical disease-free survival (DFS) is improved by adding 6 months of androgen suppression (AS; two injections of every-3-months depot of luteinizing hormone-releasing hormone agonist) to primary radiotherapy (RT) for intermediate- or high-risk localized prostate cancer. PATIENTS AND METHODS A total of 819 patients staged: (1) cT1b-c, with prostate-specific antigen (PSA) ≥ 10 ng/mL or Gleason ≥ 7, or (2) cT2a (International Union Against Cancer TNM 1997), with no involvement of pelvic lymph nodes and no clinical evidence of metastatic spread, with PSA ≤ 50 ng/mL, were centrally randomized 1:1 to either RT or RT plus AS started on day 1 of RT. Centers opted for one dose (70, 74, or 78 Gy). Biochemical DFS, the primary end point, was defined from entry until PSA relapse (Phoenix criteria) and clinical relapse by imaging or death of any cause. The trial had 80% power to detect hazard ratio (HR), 0.714 by intent-to-treat analysis stratified by dose of RT at the two-sided α = 5%. RESULTS The median patient age was 70 years. Among patients, 74.8% were intermediate risk and 24.8% were high risk. In the RT arm, 407 of 409 patients received RT; in the RT plus AS arm, 403 patients received RT plus AS and three patients received RT only. At 7.2 years median follow-up, RT plus AS significantly improved biochemical DFS (HR, 0.52; 95% CI, 0.41 to 0.66; P < .001, with 319 events), as well as clinical progression-free survival (205 events, HR, 0.63; 95% CI, 0.48 to 0.84; P = .001). In exploratory analysis, no statistically significant interaction between treatment effect and dose of RT could be evidenced (heterogeneity P = .79 and P = .66, for biochemical DFS and progression-free survival, respectively). Overall survival data are not mature yet. CONCLUSION Six months of concomitant and adjuvant AS improves biochemical and clinical DFS of intermediate- and high-risk cT1b-c to cT2a (with no involvement of pelvic lymph nodes and no clinical evidence of metastatic spread) prostatic carcinoma, treated by radiation.