Miracle-dz/UniFAR-FTUs huggingface dataset:
A delayed diagnosis of X-linked hyper IgM syndrome complicated with toxoplasmic encephalitis in a child

Introduction: The X-linked hyper-immunoglobulin M syndrome (XHIGM) is an uncommon primary combined immunodeficiency disease caused by CD40L gene mutations. A delayed or missed diagnosis of XHIGM is common and concerning, owing to atypical immunoglobulin profile and phenotype of some patients, low recognition, and limited knowledge of clinicians on XHIGM in some underdeveloped areas. Opportunistic infections are a prominent clinical feature of XHIGM. However, toxoplasma encephalitis occurs sporadically and is extremely rare in patients with XHIGM. Diagnostic and therapeutic procedure: A 2 years and 10 months’ old male suffered from 3 times of serious infection since 1 year and 4 months of age. Although with history of recurrent respiratory infections, protracted diarrhea, persistent or intermittent neutropenia companioned with oral ulcer, and a typical immunoglobulin profile during his second disease attack, the consideration of XHIGM was still completely ignored because of our low recognition and limited knowledge of this disorder. The diagnosis of XHIGM was ultimately confirmed by detection of elevated serum IgM concentration, decreased serum IgG and IgE concentration, and identification of a mutation c.654C>A (p.C218X) in CD40L gene. Given clinical manifestation of lethargy, uncontrollable somnolence and ataxia, a cat/dog exposure history, positive serum Toxoplasma gondii (T gondii) IgM, positive cerebrospinal fluid T gondii PCR results, and typical characteristics of brain magnetic resonance imaging as multiple rings liked nodules lesions in bilateral cerebral hemisphere cortex, bilateral basal ganglia, and dorsal thalamus, the diagnosis of toxoplasmic encephalitis was considered during his third disease attack. Thereafter, oral administration of sulfadiazine and azithromycin, intravenous immunoglobulin, and subcutaneous injection of G-CSF were initiated. Regrettably, the patient abandoned the treatment because of economic factor and died 3 months after discharge. Conclusions: A more thorough clinical history and some features like recurrent respiratory infections, protracted diarrhea, and persistent or intermittent neutropenia companioned with oral ulcer could increase clinical suspicion of XHIGM. Cerebral toxoplasmosis is rare in patients with XHIGM, but still should be considered. The present study firstly reported a delayed diagnosed case of XHIGM with CD40L gene c.654C>A (p.C218X) mutant complicated with toxoplasma encephalitis in Chinese population, which highlighted the importance of CD40-CD40L interaction in cell-mediated immunity against T gondii.
Scanning tunneling microscopy imaging of organic layers on graphite

Organic monolayers of dotriacontane and tetracosanoic acid physisorbed on graphite have been studied by scanning tunneling microscopy at the liquid-solid interface. A high degree of two-dimensional ordering appeared for both the organic compounds observed : the molecules were arranged on graphite in stripelike lamellae of various shape and length. Experimental conditions for high contrast imaging are discussed.
Quantifying repetitive hand activity for epidemiological research on musculoskeletal disorders – Part II: comparison of different methods of measuring force level and repetitiveness

This paper focuses on comparisons between the different methods of assessing repetitive hand activities. Various methods were used to measure hand force and repetitiveness of hand activities on 733 subjects in the study described by Bao et al. (2006). Two definitions of repetitiveness were used in analysis of detailed time studies of repetitive hand activities and four parameters of the American Conference of Governmental Industrial Hygienists (ACGIH) hand activity level (HAL) and the Strain Index methods were estimated by ergonomists and used to quantify repetitiveness. Hand forces were measured or estimated using three different methods: 1) measured with a force gauge or mimicked on a force gauge (force matching); 2) estimated by ergonomists using rating scales; 3) self-reports by subjects. The jobs were also evaluated using the ACGIH HAL and Strain Index methods when different repetitiveness quantification methods were used. Results showed that different definitions of repetitive exertion might lead to measuring different physical exposure phenomena and produce very different results. There were poor correlations between the measures of repetitiveness estimated by the different methods. Correlations between force quantifications using different methods were also poor. This suggests that parameters measured by different methods might not be interchangeable. Both the ACGIH HAL and Strain Index methods identified more ‘hazardous’ jobs when repetitiveness was estimated by ergonomists than when it was calculated by detailed time studies of forceful hand exertions. The Strain Index method identified more ‘hazardous’ jobs than the ACGIH HAL method. Overall, the between-methods agreements were found to be moderate to substantial.
Colonic Stents for the Palliation of Malignant Colonic Obstruction

Colorectal self-expanding metal stents have revolutionized the palliative treatment of patients with advanced malignancies and those patients who present with acute colon obstruction and who were previously treated with emergent surgical decompression via formation of colostomy. The placement of stents can be fluoroscopically or non-fluoroscopically guided. The use of stents is associated with significant reduction in hospital duration, mortality and medical complications compared to surgery. The most frequent complications are stent malposition and migration, bleeding, colonic perforation and tumor ingrowth and/or overgrowth.
RNA solvation: A molecular dynamics simulation perspective

With the availability of accurate methods to treat the electrostatic long‐range interactions, molecular dynamics simulations have resulted in refined dynamical models of the structure of the hydration shell around RNA motifs. The models reviewed here range from basic Watson–Crick to more specific noncanonical base pairs, from “simple” double helices to RNA molecules displaying more complex tertiary folds, and from DNA/RNA hybrid double helices to RNA hybrids formed with a chemically modified strand. © 2001 John Wiley & Sons, Inc. Biopolymers (Nucleic Acid Sci) 56: 266–274, 2001
Radical Versus Incremental Innovation: The Importance of Key Competences in Service Firms

Today, innovation often takes place using open practices and relies on many sources for knowledge and information. The purpose of this article is to study how different knowledgebased antecedents influence the ability of service organizations to innovate. Using data about the Norwegian service sector from the 2010 Community Innovation Survey, we examined how three types of competence, namely R&D activities, employee-based activities, and customer-related activities, influence the propensity of firms to introduce radical or incremental innovations. The results show that R&D-based competence is important for service firms when pursuing radical innovations, whereas employee-based activities such as idea collaboration are only found to influence incremental innovations. The use of customer information was found to be an important driver for both radical and incremental innovations. The findings points to managerial challenges in creating and balancing the types of competence needed, depending on type of innovation targeted by an organization. A manager is responsible for the application and performance of knowledge.
The contribution of field-induced morphological change to the electrical aging and breakdown of polyethylene

A brief review of the early literature is given which provides evidence that electrically-induced mechanical stresses make an important contribution to the electrical breakdown of solid dielectrics. Special attention is given to polyethylene and the manner in which this semi-crystalline polymer yields under mechanical stress by microvoid, crack and craze development in the amorphous phase between the lamellar crystallites. The nature of the forces induced by an electrical field is considered and it is shown that a significant component of tensile stress is generated in a direction orthogonal to the field and can become large as breakdown is approached. This suggests a correlation between the responses of the polymer to mechanical and electrical stresses and consequently the importance of morphology in determining the latter. The likely effect of field-induced morphological change on charge transport and electrode processes is described and its underlying contribution to possible aging markers for polyethylene, such as high field conduction, electroluminescence, space charge and charge packets is considered.
Acceptance and Commitment Therapy delivered in a dyad after a severe traumatic brain injury: A feasibility study

Objective: There is a high prevalence of complex psychological distress after a traumatic brain injury but limited evidence of effective interventions. We examined the feasibility of Acceptance and Commitment Therapy after a severe traumatic brain injury using the criteria, investigating a therapeutic effect, and reviewing the acceptability of measures, treatment protocol, and delivery method (in a dyad of two clients and a therapist). Method: Two male outpatients with severe traumatic brain injury and associated psychological distress jointly engaged in a seven session treatment program based on Acceptance and Commitment Therapy principles. Pre- and post-treatment measures of mood, psychological flexibility, and participation were taken in addition to weekly measures. Results: The intervention showed a therapeutic effect with one participant, and appeared to be acceptable for both participants with regard to program content, measures, and delivery mode by in a dyad. One participant showed both significant clinical and reliable change across several outcome measures including measures of mood and psychological flexibility. The second participant did not show a reduction in psychological inflexibility, but did show a significant drop in negative affect. Significant changes pre- to post-treatment for measures of participation were not indicated. Qualitatively, both participants engaged in committed action set in accordance with their values. Conclusions: This study suggests that Acceptance and Commitment Therapy may be feasible to be delivered in a dyad with individuals who have a severe traumatic brain injury. A further test of its potential efficacy in a phase II clinical trial is recommended.
A Narrative View of Art Therapy and Art Making by Women with Breast Cancer

Art therapy (with an art therapist) and art making (without an art therapist) show promise as avenues for psychosocial support for women with breast cancer. The purpose of this study was to gain an in-depth understanding of how 17 women with breast cancer in Canada and the USA used art therapy and their own art making to address their psychosocial needs, focusing particularly on meaning making. Narrative analysis of interviews yielded four storylines: Art and Art Therapy as a Haven; Getting a Clearer View; Clearing the Way Emotionally; and Enhancing and Enlivening the Self. The storylines show existence being affirmed, confirmed and proclaimed through visual artistic expression and meaning making being achieved through physical acts of making.
Comparison of intramuscular methotrexate and gold sodium thiomalate in the treatment of early erosive rheumatoid arthritis: 12 month data of a double-blind parallel study of 174 patients.

The objective was to compare the safety and efficacy of methotrexate (MTX) and gold sodium thiomalate (GSTM) in patients with early erosive rheumatoid arthritis (RA). A total of 174 patients with active early erosive RA without deformities were enrolled in a 12 month, two-centre double-blind randomized trial. They received a weekly i.m. dose of 15 mg MTX (n = 87) or 50 mg GSTM (n = 87), respectively. Clinical and laboratory evaluations were carried out every 3 months in all patients, including the withdrawals. Ten patients (11.5%) in the MTX group and 21 patients (24.1%) in the GSTM group achieved a clinical remission of the disease [no swollen joints, erythrocyte sedimentation rate (ESR) < 20 mm, no steroids] within the study period (P < 0.05). An at least marked improvement (> 50% reduction of the number of swollen and tender joints and the ESR) was assessed in 59/87 (68%) and 66/87 (76%) patients treated with MTX or GSTM, respectively (P > 0.05). Significantly more patients in the GSTM group were withdrawn due to toxicity (six MTX/32 GSTM). A total of 126 patients (73 on MTX and 53 on GSTM) completed 12 months on their original medication. In the completers, a significant improvement of > 50% compared to baseline was noted in all six clinical variables [morning stiffness, joint count of swollen and tender joints, Lansbury index, grip strength and activities of daily living (ADL) score], the ESR and the C-reactive protein, without intergroup differences. The number of patients taking prednisone was reduced from 21 to 7% in the MTX group and from 15 to 4% in the GSTM group. While significantly more patients achieved a clinical remission with GSTM treatment, tolerability was significantly better with MTX.
Foreign body in the nasopharynx; masquerading as pharyngotonsillitis

: Foreign body (FB) in the aerodigestive tracts has been commonly reported but findings of impacted foreign bodies in the nasopharynx following inhalation/ingestion are very rare. Most of the FB gets lodged as a result of forceful vomiting, coughing,and digital manoeuvres for removal of FB in the oropharynx. Several objects have been identified lodged in the nasopharynx. No age group is spared although most victims are children under 10 years of age. Foreign bodies in the nasopharynx can be uneventful or potentially dangerous depending on type, size and location as it may cause sudden airway obstruction, or local pressure necrosis of alimentary or respiratory tract or both. Presentation in children is usually with a history of swallowed FB which may not be witnessed in children, choking, cough, bluish discolouration, breathlessness, drooling of saliva, halitosis, rhinorrhoea, snoring, stridor, dysphagia, vomiting and dysphonia. A foreign body in the nasopharynx is a challenge to patient, parents, the physician and the ENT surgeon, as it may be miss-diagnosed, in the index case, as Pharyngotonsilitis. The index patient, a 14 month child,was presented with a two days history of fever, drooling of saliva, mouth breathing, and digital manipulation. Lateral imaging of the post nasal space following initial treatment with antibiotics, aided the diagnosis of a periwinkle shell in the nasopharyngx that was removed during a nasopharyngoscopy under general anaesthesia without complication and subsequently discharged home. This emphasizes a high index of suspicion for FB in the nasopharynx in children with history of missing foreign body, digital manipulation, drooling of saliva and mouth breathing. Lateral X-ray of the postnasal space, neck, chest and abdomen should be the minimum investigation required.
Mental Disorder and Season of Birth—A Southern Hemisphere Study

Summary Studies on the relationship between season of birth and mental disorder have been substantially confined to northern hemisphere regions. Such studies have generally found an excess of winter births of schizophrenics, and variably an excess of winter births of manic-depressive and mentally retarded patients. In the present study information on sex, diagnosis and date of birth was obtained on all 20,358 patients first admitted to psychiatric facilities in New South Wales between July 1970 and June 1974 and born in New South Wales. The collective 1962–71 monthly live-births for New South Wales were used as a control. A significant winter excess was found for the female schizophrenic group, while a significant spring excess was found for neurotic patients, most marked in those with anxiety neurosis. It is hypothesized that the relationship between schizophrenia and winter birth is consequent upon a greater sensitivity of schizophrenics to those physiological factors which determine conception in the general population.
Fiscal Deficits Financing: Implications for Monetary Policy Formulation in Uganda

The relationship among budget deficit, money creation and inflation in Uganda is analyzed using a triangulation of Vector Error Correction model (VECM) and pair-wise Engel-Granger non- causality test techniques over the period 1999Q4 - 2012Q3. Results suggest that fiscal deficits do not seem to necessarily trigger inflation in the short-run, but in the long-run. Also, unidirectional causality running from inflation to the fiscal deficit, from money supply to the fiscal deficit, and a feedback causal effect between money supply and inflation in the short-run are found. Thus, in the short-term, contractionary monetary policy to reduce inflation in Uganda need not focus on budget deficit reduction, but rather on other macroeconomic determinants of inflation, and inflation should be contained to mitigate its effect on the budget deficit.
Coping specificity: The case of women coping with infertility treatments

Customizing the measurement of coping to a specific situation can answer some of the concerns regarding its measurement by checklist. A context-specific measure of coping with infertility was developed on the basis of theoretical principles of coping, interviews with women and providers, and existing findings. Data on the resulting Coping with Infertility questionnaire was collected from 652 Israeli women undergoing treatment and meta-strategies of coping were identified on the basis of a hierarchical structure of the coping subscales. About half of the women also filled in adjustment measures and findings showed differential associations of coping strategies to negative and positive indicators of psychological adjustment. Taking into account coping specificity can highlight strategies that function in ways that are unique to the context. This approach could be useful as a step in the assessment and understanding of coping with a specific health threat, which can guide further research and interventions designed to improve coping effectiveness.
Cultural Predictors of Caregiving Burden of Chinese-Canadian Family Caregivers*

ABSTRACT The growth of research knowledge on culturally diverse family caregivers for the aging population lags behind the increase of culturally diverse populations in Canada. This study examines the effects of culture, as manifested through cultural variables, on the caregiving burden of family caregivers in a Chinese-Canadian community. A random sample of 339 Chinese-Canadian caregivers for elderly relatives completed a telephone survey. Results of hierarchical stepwise multiple regression analysis reported the predicting effects of culture-related variables on caregiving burden. The findings indicated that being an immigrant, having a Western or non-Western religion as compared to having no religion, and having a lower level of filial piety, predicted a higher level of caregiving burden. Chinese tradition does not exempt the caregivers from being burdened. Policies and practices should address the needs of family caregivers according to the intra-cultural variations identified in this study. RÉSUMÉ Les communautés culturelles se font de plus en plus nombreuses au Canada, tandis que les connaissances sur la prestation de soins familiaux auprès des personnes âgées dans ces milieux ethniques différents stagnent. l'étude examine l'influence de la culture, qui s'exprime par certains paramètres, sur le fardeau des dispensateurs de soins familiaux dans une communauté canadienne d'origine chinoise. l'échantillon tiré au hasard comprend 339 Canadiens d'origine chinoise, dispensateurs de soins auprès d'un proche âgé, qui ont répondu à un sondage téléphonique. l'analyse de régression multiple hiérarchique rend compte de l'effet des paramètres culturels sur la lourdeur du fardeau des soins. Selon les constatations, le fait d'être un immigrant, de religion occidentale ou non, plutôt qu'athée, éprouvant peu de piété filiale sont des indicateurs prévisionnels d'un très lourd fardeau de soins. La tradition chinoise n'exempte pas le dispensateur de soins de son fardeau. Les politiques et les pratiques devraient combler les besoins des dispensateurs de soins familiaux en fonction des facteurs intraculturels précisés dans l'étude.
SUFFICIENT CONDITIONS FOR THE T (T0)-SOLVABILITY OF FINITE GROUPS

Let G be a finite group. We say that G is a T0-group if its Frattini quotient group G/Φ(G) is a T -group, where by a T -group we mean a group in which every subnormal subgroup is normal. In this paper, we investigate the structure of the group G if G is the product of two solvable T -groups (T0-groups) H and K such that H permutes with every subgroup of K and K permutes with every subgroup of H (that is, H and K are mutually permutable) and that (|G : H|, |G : K|) = 1. Some structure theorems are also discussed.
Bayesian model of the dynamics of motion integration in smooth pursuit and plaid perception

In this thesis, a model of motion integration is described which js based on a recursive Bayesian estimation process. The model displays a dynamic behaviour qualitatively similar to the dynamics of the motion integration process observed experimentally in smooth eye pursuit and plaid perception. The computer simulations of the model applied to smooth pursuit eye movements confirm the psychophysical data both in humans and monkeys, and the physiological data in monkeys. TTie temporal dynamics of motion integration is demonstrated together with its dependence on contrast, size of the stimulus and added noise. A new theoretical approach to explaining piaid perception has been developed, based on both the application of the model and a novel geometrical analysis of the plaid's pattern. It is shown that the results from simulating the model are consistent with the psychophysical data about the plaid motion. Furthermore, by formulating the model as an approximate version of a Kaiman fiher algorithm, it is shown (bat the model can be put into a neurally plausible, distributed recurrent form which coarsely coiresponds to the recurrent circuitiy of visual cortical areas VI and MT. TTie model thus provides further support for the notion that the motion integration process is based on a form of Bayesian estunation, as has been suggested by many psychophysical studies, and moreover suggests that the observed dynamic properties of this process are the resuh of the recursive nature of the motion estimation. List of
Chapter 2 Mechanisms of Cerebral Edema Leading to Early Seizures After Traumatic Brain Injury

Epidemiological data support a link between traumatic brain injury (TBI) and seizures. TBI accounts for approximately 16 % of acute symptomatic seizures which usually occur in the first week after trauma. Children are at higher risk for posttraumatic seizures than adults and experience greater morbidity and mortality from cerebral edema (CE). CE is responsible for half of the mortality associated with TBI. A recent book chapter summarizes the most important features of posttraumatic seizure. In this chapter we will summarize features relevant to the link between cerebral edema, cerebrovascular events and seizures after TBI. In addition, we will discuss the potential autoimmune implications of TBI.