Miracle-dz/UniFAR-FTUs huggingface dataset:
The effectiveness of STEM mentoring program in promoting interest towards STEM

STEM mentoring program were introduced in order to overcome the declining interest in STEM subjects in schools. This study aims to measure the effectiveness of STEM mentoring programs on the students’ interest towards STEM. Comparisons between girls and boys on their interest towards STEM were also conducted. The STEM Mentoring programs in this study consisted of an array of the program from various faculties namely (i) BITARA STEM and STEM Career Interest from Faculty of Education (FPEND), (ii) CRYSTAL from Faculty of Engineering and Built Environment (FKAB), and (iii) Science Camp and SEE Nature from the Faculty of Science and Technology (FST). This study used post-test control group design involved 198 students in one of the states in Malaysia. Data garnered from the study was described by means of descriptive analysis, which later followed by inferential analysis using independent sample t-test. Overall, the findings revealed that there is significant difference between girls in treatment group in interest towards mathematics. This study showed that research should be done more thoroughly on mentoring program, need to find out the suitable framework in implementing STEM mentoring programs and possible implementation of Blended Mentor Mentee programs for further research to get a corroborative evidence.
Exploring Native-English-Speaking EFL Teacher Classroom Observations : Perspectives and Expectations

education observational process and indicate emphasizes corrective along with the development of competence. Limitations of the study are the nature of its small scale and confinement to a workplace, but for all those involved, it points to the need for organizational change, and initially, the development of a focus group to advance such changes and explore the issues further.
Problematic Alcohol Use and Acute Intoxication Predict Anger-Related Attentional Biases: A Test of the Alcohol Myopia Theory

Previous research has demonstrated a significant association between alcohol and aggression. However, the precise mechanisms underlying this relationship have yet to be fully elucidated. In the present study, we examined alcohol’s effects on an attentional bias toward aggressogenic cues as the first step in a possible mediation model of alcohol-facilitated intimate partner aggression. More specifically, we tested an interactive effect of problematic alcohol use and acute alcohol intoxication on an attentional bias toward anger words. Participants in this study were 249 male and female heavy drinkers from the community with a history of past-year intimate partner aggression perpetration who participated in an alcohol-administration laboratory study assessing the effect of alcohol intoxication on cognitive biases. Multiple linear regression was used to test the proposed moderation model. Acute alcohol intoxication moderated the effect of problematic alcohol use on an attentional bias toward anger, with this effect being stronger for individuals in the alcohol compared to no-alcohol control condition. These findings suggest that problematic drinkers may be more likely to attend to aggressogenic stimuli while acutely intoxicated, relative to when they are sober.
Effect of CTLA4‐Ig (abatacept) treatment on T cells and B cells in peripheral blood of patients with polymyositis and dermatomyositis

We aimed to evaluate in vivo effects of abatacept on phenotypes of T and B cells in the circulation of myositis patients in a sub‐study of the ARTEMIS trial. Twelve patients with paired frozen PBMCs before and after 6‐month abatacept treatment were included in this sub‐study where mass cytometry (CyTOF) was chosen as a technology to be tested for its utility in a real‐life clinical immune monitoring setting. Using CyTOF, the peripheral T cell phenotypes demonstrated considerable variation over time and between individuals precluding the identification of treatment‐specific changes. We therefore conclude that studies of patient cohorts displaying wide clinical heterogeneity using mass cytometry must be relatively large in order to be suited for discovery research and immune monitoring. Still, we did find some correlations with functional muscle outcome, namely positive correlations between the ratio of CD4+ T cells and CD8+ T cells (CD4/CD8) in peripheral blood samples both at baseline and after treatment with muscle endurance improvement as assessed by the functional index‐2 (FI‐2) test. Our data suggest that the CD4/CD8 ratio in circulation at time of active disease may be a predictor of treatment efficacy in myositis patients.
Investigating Window Segmentation on Mental Fatigue Detection Using Single-Channel EEG

Mental fatigue condition can be a serious problem if it is not handled properly. It also has a correlation with acute or chronic illness. Many research has been done to detect mental fatigue condition using several methods. The Physiological method is proved as a robust indicator, one of which is electroencephalogram (EEG). EEG is the most widely used as a physiological indicator in the few decades. However, most of the research in mental fatigue detection based on EEG used long time segment and complex computation method. In this paper, a window segmentation was employed to investigate mental fatigue information that might contain in a specific segment. Power percentage feature was extracted from each segment. The detection of mental fatigue employs three classifiers, LDA, QDA, and SVM. According to our experiment, LDA yields the highest performance with 92.82 % of accuracy. This result obtained from 30s length window segment which contains only the first and the last segment of the EEG signal data points. This result showed that information of mental fatigue in EEG signal may be better detected in short time segment and can be found in specific window segment.
Modulation of Fear and Arousal Behavior by Serotonin Transporter (5-HTT) Genotypes in Newly Hatched Chickens

The serotonin transporter (5-HTT) plays a key role in regulating serotonergic transmission via removal of serotonin (5-hydroxytryptamine, 5-HT) from synaptic clefts. Alterations in 5-HTT expression and 5-HT transmission have been shown to cause changes to adult behavior including fear. The objective of the present study was to investigate the 5-HTT role in fear in birds at the very early stages of post-hatching life. Using an avoidance test with an elevated balance beam, which was based on depth perception and the respective fear of heights, we assessed fear-related avoidance behaviors of newly hatched chicks of the three functional 5-HTT genotypes W/W, W/D and D/D. Newly hatched chicks of the genotype D/D, which was linked to high 5-HTT expression, showed less intensive avoidance responses as measured by decreased latency to jump than W/W and W/D chicks. Further, significantly fewer D/D hens than W/W hens showed fear-like behavior that resembled a freezing response. Furthermore, in an arousal test the arousal reaction of the chicks in response to an acute short-term visual social deprivation in the home compartment was assessed 5 weeks after hatching, which also revealed that D/D chicks exhibited decreased arousal reaction, compared to W/W chicks. Thus, the results indicate that fear responses differ in D/D chicks in the early post-hatching periods, possibly due to the different expression of 5-HTT respectively 5-HT levels in this strain.
Osteogenic differentiation of Wharton’s jelly-derived mesenchymal stem cells cultured on WJ-scaffold through conventional signalling mechanism

Abstract Wharton’s jelly-derived extracellular matrix (WJ-ECM) has attracted researcher’s attention for its biomedical applications. Previously, we fabricated a biomimetic spongy scaffold from decellularized WJ-ECM and, in this study, we sought to examine the osteogenic inductive potential of this scaffold and its underlying mechanism. To address this question, mesenchymal stem cells (MSCs) were isolated from WJ using a mechanical method and cultured on the scaffold, under dynamic condition, for over 21 days in the presence or absence of osteogenic medium. The status of signalling pathways involved in the osteogenic differentiation and the expression profile of integrins in the WJ-derived MSCs (WJ-MSCs) were examined. WJ-MSCs displayed differentiation capacities and expressed surface antigens, characteristics of MSCs. Histologically, WJ-MSCs seeded on the scaffold showed a proper cellular attachment, penetration and migration. They also exhibited a higher degree of alkaline phosphatase activity, calcium deposition and osteogenic gene expression, than those cultured in 2D condition. The expression of Wnt, BMP and TGF-β signalling target genes together with that of α2, αv and β1 integrins was increased in WJ-MSCs in both presence and absence of osteogenic induction medium. Taken together, our results demonstrate that WJ-derived scaffold induces osteogenic differentiation of WJ-MSCs, possibly through activating integrins and subsequently conventional intracellular signalling pathways.
Grief and Post-traumatic Growth Following Miscarriage: The Role of Meaning Reconstruction and Partner Supportive Communication

Abstract This study used the meaning reconstruction model of bereavement and the theory of conversationally induced reappraisals to investigate factors that influence the association between grief following a miscarriage and post-traumatic growth. Participants included 298 women who had experienced a miscarriage within the previous year. As predicted, a moderate level of grief corresponded with the most post-traumatic growth among bereaved mothers and meaning reconstruction and partner supportive communication moderated this association. The results clarify how grief is integral to post-traumatic growth in the aftermath of a miscarriage and how intrapersonal and interpersonal coping resources can foster post-traumatic growth in the face of grief.
Bacterial Metabolism During Biofilm Growth Investigated by 13C Tracing

This study investigated the metabolism of Pseudomonas aeruginosa PAO1 during its biofilm development via microscopy imaging, gene expression analysis, and 13C-labeling. First, dynamic labeling was employed to investigate glucose utilization rate in fresh biofilms (thickness 40∼60 micrometer). The labeling turnover time of glucose-6-P indicated biofilm metabolism was substantially slower than planktonic cells. Second, PAO1 was cultured in continuous tubular biofilm reactors or shake flasks. Then 13C-metabolic flux analysis of PAO1 was performed based on the isotopomer patterns of proteinogenic amino acids. The results showed that PAO1 biofilm cells during growth conserved the flux features as their planktonic mode. (1) Glucose could be degraded by two cyclic routes (the TCA cycle and the Entner-Doudoroff-Embden-Meyerhof-Parnas loop) that facilitated NAD(P)H supplies. (2) Anaplerotic pathways (including pyruvate shunt) increased flux plasticity. (3) Biofilm growth phenotype did not require significant intracellular flux rewiring (variations between biofilm and planktonic flux network, normalized by glucose uptake rate as 100%, were less than 20%). (4) Transcription analysis indicated that key catabolic genes in fresh biofilm cells had expression levels comparable to planktonic cells. Finally, PAO1, Shewanella oneidensis (as the comparing group), and their c-di-GMP transconjugants (with different biofilm formation capabilities) were 13C-labeled under biofilm reactors or planktonic conditions. Analysis of amino acid labeling variances from different cultures indicated Shewanella flux network was more flexibly changed than PAO1 during its biofilm formation.
New resources and ideas for semantic parser induction

In this thesis, we investigate the general topic of computational natural language understanding (NLU), which has as its goal the development of algorithms and other computational methods that support reasoning about natural language by the computer. Under the classical approach, NLU models work similar to computer compilers (Aho et al., 1986), and include as a central component a semantic parser that translates natural language input (i.e., the compiler’s high-level language) to lower-level formal languages that facilitate program execution and exact reasoning. Given the difficulty of building natural language compilers by hand, recent work has centered around semantic parser induction, or on using machine learning to learn semantic parsers and semantic representations from parallel data consisting of example text-meaning pairs (Mooney, 2007a). One inherent difficulty in this data-driven approach is finding the parallel data needed to train the target semantic parsing models, given that such data does not occur naturally “in the wild” (Halevy et al., 2009). Even when data is available, the amount of domainand language-specific data and the nature of the available annotations might be insufficient for robust machine learning and capturing the full range of NLU phenomena. Given these underlying resource issues, the semantic parsing field is in constant need of new resources and datasets, as well as novel learning techniques and task evaluations that make models more robust and adaptable to the many applications that require reliable semantic parsing. To address the main resource problem involving finding parallel data, we investigate the idea of using source code libraries, or collections of code and text documentation, as a parallel corpus for semantic parser development and introduce 45 new datasets in this domain and a new and challenging text-to-code translation task. As a way of addressing the lack of domainand language-specific parallel data, we then use these and other benchmark datasets to investigate training semantic parsers on multiple datasets, which helps semantic parsers to generalize across different domains and languages and solve new tasks such as polyglot decoding and zero-shot translation (i.e., translating over and between multiple natural and formal languages and unobserved language pairs). Finally, to address the issue
Improving the quality of care for inflammatory bowel disease

Great strides have been achieved in the development of quality-of-care measures and standards for inflammatory bowel disease (IBD) over the last decade. The central structural component of care in IBD revolves around the multidisciplinary team, which should be equipped with the necessary resources to operate and implement decisions. Process measures have been defined by interest groups and can be adapted into process tools for the delivery of care for various patient subgroups and clinical scenarios. The emerging treat-to-target approach to IBD management may be used to achieve optimal long-term and holistic patient-centred outcomes, such as survival, control of inflammation and disease progression, symptomatic remission, quality of life and complications. Other important quality-of-care outcome measures for IBD include disutility of care, healthcare utilization and other patient-reported outcomes such as nutritional status and impact of fistulae. The current challenge for healthcare providers and health systems is the integration of quality-of-care structures and processes into clinical practice, and the consistent delivery of updated evidence-based quality IBD care to various patient populations by individual health care providers. Finally, the awareness and appreciation for quality of care in IBD is increasing in Asia, and Asian healthcare institutions should be encouraged to take the lead in improving the quality of care in IBD.
Long-term low salt diet increases blood pressure by activation of the renin-angiotensin and sympathetic nervous systems

ABSTRACT Background The aim of this study was to investigate the effect of long-term low salt diet on blood pressure and its underlying mechanisms. Methods Male Sprague-Dawley (SD) rats were divided into normal salt diet group (0.4%) and low salt diet group (0.04%). Blood pressure was measured with the non-invasive tail-cuff method. The contractile response of isolated mesenteric arteries was measured using a small vessel myograph. The effects on renal function of the intrarenal arterial infusion of candesartan (10 μg/kg/min), an angiotensin II receptor type 1 (AT1R) antagonist, were also measured. The expressions of renal AT1R and mesenteric arterial α1A, α1B, and α1D adrenergic receptors were quantified by immunoblotting. Plasma levels of angiotensin II were also measured. Results Systolic blood pressure was significantly increased after 8 weeks of low salt diet. There were no obvious differences in the renal structure between the low and normal salt diet groups. However, the plasma angiotensin II levels and renal AT1R expression were higher in low than normal salt diet group. The intrarenal arterial infusion of candesartan increased urine flow and sodium excretion to a greater extent in the low than normal salt diet group. The expressions of α1A and α1D, but not α1B, adrenergic receptors, and phenylephrine-induced contraction were increased in mesenteric arteries from the low salt, relative to the normal salt diet group. Conclusion Activation of the renin-angiotensin and sympathetic nervous systems may be involved in the pathogenesis of long-term low salt diet-induced hypertension.
Decreased Pituitary Height and Stunted Linear Growth After Radiotherapy in Survivors of Childhood Nasopharyngeal Carcinoma Cases

To examine the morphological changes of the pituitary glands and linear growth of childhood nasopharyngeal carcinoma (NPC) cases who accepted radiotherapy. A total of 90 children (i.e., age less than 18 years) who were diagnosed as NPC at Sun Yat-sen University Cancer Center from January 2009 to January 2016 were identified by reviewing medical records. Two radiologists reviewed and measured the pre-radiation, post-radiation, and the latest available pituitary gland heights independently. Patients' current height information was collected by telephone interviews. We compared the pituitary height differences using paired t-tests and estimated the pituitary height trajectories within each sex by mixed regression models. Height-for-age Z-score was calculated for each patient using the WHO growth reference data for 5–19 years as reference. Most of the included participants were of male sex (75.6%) and over half were diagnosed at stage IV (58.4%). Among the 90 included participants, 89 had one repeated measurement of the pituitary height and 79 had two repeated measurements of the pituitary height. Seventy six of the 89 childhood NPC participants had reduced pituitary heights after radiation and accounted for 85.4% of the whole population. The means of the pituitary heights before and after radiotherapy were 6.4 ± 1.3 mm and 5.6 ± 1.2 mm (P < 0.001), respectively. The mean of height-for-age Z-score for childhood NPC cases was significantly below zero (−0.54, 95% CI = −0.74, −0.34). We concluded that childhood NPC cases had decreased pituitary heights and stunted linear growth after radiotherapy.
Disease or not, aging is easily treatable

Is aging a disease? It does not matter because aging is already treated using a combination of several clinically-available drugs, including rapamycin. Whether aging is a disease depends on arbitrary definitions of both disease and aging. For treatment purposes, aging is a deadly disease (or more generally, pre-disease), despite being a normal continuation of normal organismal growth. It must and, importantly, can be successfully treated, thereby delaying classic age-related diseases such as cancer, cardiovascular and metabolic diseases, and neurodegeneration.
Review of treatment methods of patients with uncomplicated teeth fractures.

OBJECTIVE Introduction: Taking into consideration the high prevalence of dental trauma, the issue dental trauma management in the frontal dentition is relevant, considering the principles of biological, economical feasibility and clinical features of each case. The aim: The purpose of this review article is to draw dentists' attention to the high prevalence of uncomplicated fractures of teeth (without pulp chamber exposure) and to highlight the most effective methods for their managment. PATIENTS AND METHODS Materials and methods: We have processed about 50 scientific sources devoted to the treatment of traumatic lesions of teeth. Among them are articles, scientific researches, clinical cases, laboratory researches. CONCLUSION Conclusions: The most appropriate method for teeth restoration in a case of uncomplicated fracture is to preserve the fragment of the tooth with its further reattachment applying an adhesion protocol with the preliminary preparation of hard tissues of teeth. To achieve the best aesthetic results and increase the endurance of restoration it is expedient to cover the repartitioned fragment of a tooth with ceramic veneers.
Potential of Curcumin as Antiproliferative Drug for Developing Drug Eluting Stent: A Brief Review

Curcumin is a medicinal substance that has been extensively used for long time in biomedical applications by various ways, having many important characteristics such as anticoagulation, anti-inflammatory and anti-proliferation. These traits make curcumin a great potential for use in the development of drug coated stents to prevent in-stent restenosis subsequently stent installed in the blood vessel. This paper reviews a number of studies that attempt to develop drug eluting stents by using curcumin or ginseng as an anti-proliferation agent.
Spatiotemporal Expression of GRP78 in the Blood Vessels of Rats Treated With 3-Nitropropionic Acid Correlates With Blood–Brain Barrier Disruption

Glucose-regulated protein (GRP78) or BiP, a 78-kDa chaperone protein located in the endoplasmic reticulum (ER), has recently been reported to be involved in the neuroglial response to ischemia-induced ER stress. The present study was designed to study the expression patterns of this protein and the cell types involved in the induction of GRP78 expression in rats treated with the mitochondrial toxin 3-nitropropionic acid (3-NP). GRP78 immunoreactivity was almost exclusively localized to striatal neurons in saline-treated controls, but GRP78 expression was induced in activated glial cells, including reactive astrocytes and activated microglia/macrophages, in the striata of rats treated with 3-NP. In the lesion core, increased GRP78 immunoreactivity was observed in the vasculature; this was evident in the lesion periphery of the core at 3 days after lesion induction, and was evenly distributed throughout the lesion core by 7 days after lesion induction. Vascular GRP78 expression was correlated, both temporally and spatially, with infiltration of activated microglia into the lesion core. In addition, this was coincident with the time and pattern of blood–brain barrier (BBB) leakage, detected by the extravasation of fluorescein isothiocyanate-albumin, an established BBB permeability marker. Vascular GRP78-positive cells in the lesion core were identified as endothelial cells, smooth muscle cells, and adventitial fibroblast-like cells, in which GRP78 protein was specifically localized to the cisternae of the rough ER and perinuclear cisternae, but not to other organelles such as mitochondria or nuclei. Thus, our data provide novel insights into the phenotypic and functional heterogeneity of GRP78-positive cells within the lesion core, suggesting the involvement of GRP78 in the activation/recruitment of activated microglia/macrophages and its potential role in BBB impairment in response to a 3-NP-mediated neurotoxic insult.