Miracle-dz/UniFAR-FTUs huggingface dataset:
Analyse morphométrique des molaires déciduales et définitives dans le genre Homo : perspectives phylogénétiques et biogéographiques

Les travaux concernant la phylogenie des hominides se heurtent au probleme de la representativite de registre fossile. Les restes dentaires presentent alors un grand interet car ce sont les elements anatomiques les mieux preserves. La morphologie des couronnes des molaires definitives et deciduale dans le genre Homo a ainsi ete analysee par une methode de morphometrie geometrique : les transformees de Fourier radiales. L'originalite de la morphologie des molaires chez les Neandertaliens est de��montree par cette approche, ainsi que leur proximite morphologique avec des fossiles europeens plus anciens. Ces resultats permettent d'envisager une differenciation morphologique des le debut du Pleistocene moyen, voir plus ancienne, en Europe. Par ailleurs, une analyse de la variabilite neandertalienne a permis de mettre en evidence une correlation entre distances morphologiques et geographiques pour les premieres molaires superieures.
CD19 Signaling Pathways Play a Major Role for Murine AIDS Induction and Progression

Infection of genetically susceptible mice with the LP-BM5 mixture of murine leukemia viruses including an etiologic defective virus (BM5def) causes an immunodeficiency syndrome called murine AIDS (MAIDS). The disease is characterized by interactions between B cells and CD4+ T cells resulting in polyclonal activation of both cell types. It is known that BM5def is expressed at highest levels in B cells and that B cells serve as viral APC. The CD19-CD21 complex and CD22 on the surface of B cells play critical roles as regulators of B cell responses to a variety of stimuli, influencing cell activation, differentiation, and survival. CD19 integrates positive signals induced by B cell receptor ligation by interacting with the protooncogene Vav, which leads to subsequent tyrosine phosphorylation of this molecule. In contrast, CD22 negatively regulates Vav phosphorylation. To analyze the role of CD19, CD21, Vav, and CD22 in MAIDS, we infected mice deficient in CD19, CD21 (CR2), Vav-1, or CD22 with LP-BM5 murine leukemia viruses. Infected CR2−/− mice developed MAIDS with a time course and severity indistinguishable from that of wild-type mice. In contrast, CD19 as well as Vav-1 deficiency restricted viral replication and suppressed the development of typical signs of MAIDS including splenomegaly, lymphadenopathy, and hypergammaglobulinemia. Finally, CD22 deficiency was found to accelerate MAIDS development. These results provide novel insights into the B cell signaling pathways required for normal induction and progression of MAIDS.
Dense-Caption Matching and Frame-Selection Gating for Temporal Localization in VideoQA

Videos convey rich information. Dynamic spatio-temporal relationships between people/objects, and diverse multimodal events are present in a video clip. Hence, it is important to develop automated models that can accurately extract such information from videos. Answering questions on videos is one of the tasks which can evaluate such AI abilities. In this paper, we propose a video question answering model which effectively integrates multi-modal input sources and finds the temporally relevant information to answer questions. Specifically, we first employ dense image captions to help identify objects and their detailed salient regions and actions, and hence give the model useful extra information (in explicit textual format to allow easier matching) for answering questions. Moreover, our model is also comprised of dual-level attention (word/object and frame level), multi-head self/cross-integration for different sources (video and dense captions), and gates which pass more relevant information to the classifier. Finally, we also cast the frame selection problem as a multi-label classification task and introduce two loss functions, In-andOut Frame Score Margin (IOFSM) and Balanced Binary Cross-Entropy (BBCE), to better supervise the model with human importance annotations. We evaluate our model on the challenging TVQA dataset, where each of our model components provides significant gains, and our overall model outperforms the state-of-the-art by a large margin (74.09% versus 70.52%). We also present several word, object, and frame level visualization studies.
La satisfacción de los usuarios: un determinante de la calidad asistencial

El termino "calidad" se ha convertido en una constante al hablar de salud y asistencia sanitaria. La necesidad de proporcionar un servicio de calidad surge desde el mismo instante en que se plantea la prestacion de dicho servicio. El conocimiento del grado de satisfaccion del usuario sobre los servicios de atencion enfermera, adquiere una gran importancia de cara a la optimizacion de una futura asistencia. En este trabajo se analiza el concepto de calidad asistencial y se reflexiona sobre como la satisfaccion de los usuarios es un determinante valido para su evaluacion, siempre y cuando se valoren sus multiples factores. Asimismo, ya que se trata de evaluar la calidad del servicio enfermero, se ofrece una definicion de este termino.
Reproductive status, endocrine physiology and chemical signaling in the Neotropical, swarm-founding eusocial wasp Polybia micans

In the evolution of caste-based societies in Hymenoptera, the classical insect hormones juvenile hormone (JH) and ecdysteroids were co-opted into new functions. Social wasps, which show all levels of sociality and lifestyles, are an ideal group in which to study such functional changes. Virtually all studies on the physiological mechanisms underlying reproductive division of labor and caste functions in wasps have been done on independent-founding paper wasps, and the majority of these studies have focused on species specially adapted for overwintering. The relatively little-studied tropical swarm-founding wasps of the Epiponini (Vespidae) are a diverse group of permanently social wasps, with some species maintaining caste flexibility well into the adult phase. We investigated the behavior, reproductive status, JH and ecdysteroid titers in hemolymph, ecdysteroid content of the ovary and cuticular hydrocarbon (CHC) profiles in the caste-monomorphic, epiponine wasp Polybia micans Ducke. We found that the JH titer was not elevated in competing queens from established multiple-queen nests, but increased in lone queens that lack direct competition. In queenless colonies, JH titer rose transiently in young potential reproductives upon challenge by nestmates, suggesting that JH may prime the ovaries for further development. Ovarian ecdysteroids were very low in workers but higher and correlated with the number of vitellogenic oocytes in the queens. Hemolymph ecdysteroid levels were low and variable in both workers and queens. Profiles of P. micans CHCs reflected caste, age and reproductive status, but were not tightly linked to either hormone. These findings show a significant divergence in hormone function in swarm-founding wasps compared with independently founding ones.
CsrA Regulates Translation of the Escherichia coli Carbon Starvation Gene, cstA, by Blocking Ribosome Access to the cstA Transcript

ABSTRACT CsrA is a global regulator that binds to two sites in the glgCAP leader transcript, thereby blocking ribosome access to the glgC Shine-Dalgarno sequence. The upstream CsrA binding site (GCACACGGAU) was used to search the Escherichia coli genomic sequence for other genes that might be regulated by CsrA. cstA contained an exact match that overlapped its Shine-Dalgarno sequence. cstA was previously shown to be induced by carbon starvation and to encode a peptide transporter. Expression of a cstA′-′lacZ translational fusion in wild-type and csrA mutant strains was examined. Expression levels in the csrA mutant were approximately twofold higher when cells were grown in Luria broth (LB) and 5- to 10-fold higher when LB was supplemented with glucose. It was previously shown that cstA is regulated by the cyclic AMP (cAMP)-cAMP receptor protein complex and transcribed by Εσ70. We investigated the influence of σS on cstA expression and found that a σS deficiency resulted in a threefold increase in cstA expression in wild-type and csrA mutant strains; however, CsrA-dependent regulation was retained. The mechanism of CsrA-mediated cstA regulation was also examined in vitro. Cross-linking studies demonstrated that CsrA is a homodimer. Gel mobility shift results showed that CsrA binds specifically to cstA RNA, while coupled-transcription-translation and toeprint studies demonstrated that CsrA regulates CstA synthesis by inhibiting ribosome binding to cstA transcripts. RNA footprint and boundary analyses revealed three or four CsrA binding sites, one of which overlaps the cstA Shine-Dalgarno sequence, as predicted. These results establish that CsrA regulates translation of cstA by sterically interfering with ribosome binding.
An Lrp-like Transcriptional Regulator from the ArchaeonPyrococcus furiosus Is Negatively Autoregulated*

The archaeal transcriptional initiation machinery closely resembles core elements of the eukaryal polymerase II system. However, apart from the established basal archaeal transcription system, little is known about the modulation of gene expression in archaea. At present, no obvious eukaryal-like transcriptional regulators have been identified in archaea. Instead, we have previously isolated an archaeal gene, the Pyrococcus furiosus lrpA, that potentially encodes a bacterial-like transcriptional regulator. In the present study, we have for the first time addressed the actual involvement of an archaeal Lrp homologue in transcription modulation. For that purpose, we have produced LrpA in Escherichia coli. In a cell-free P. furiosus transcription system we used wild-type and mutated lrpA promoter fragments to demonstrate that the purified LrpA negatively regulates its own transcription. In addition, gel retardation analyses revealed a single protein-DNA complex, in which LrpA appeared to be present in (at least) a tetrameric conformation. The location of the LrpA binding site was further identified by DNaseI and hydroxyl radical footprinting, indicating that LrpA binds to a 46-base pair sequence that overlaps the transcriptional start site of its own promoter. The molecular basis of the transcription inhibition by LrpA is discussed.
Intelligent Seven-DoF Robot With Dynamic Obstacle Avoidance and 3-D Object Recognition for Industrial Cyber–Physical Systems in Manufacturing Automation

In this paper, a service-oriented multiagent system (SoMAS) for the control and analysis of the cyber-physical system (CPS) in manufacturing automation utilizing a noncontact dynamic obstacle avoidance seven-DoF robot arm is presented. The interfaces of the services which the robot arm subsystem should provide to fully exploit its capability are identified. Specifically, the services of moving, object recognition, object fetching, and safety of human-robot interaction are considered as the fundamental functionalities that the robot arm should provide. The way to evaluate the quality of services (QoS) for the robot arm subsystem is also explained. To build such a robot arm subsystem, the system architecture is proposed. Also, implementation for the subsystem which includes: 3-D model-based object recognition, grasp database for object fetching, and online noncontact obstacle avoidance for the safety of human-robot interaction is provided. The experimental results demonstrate that the capability of 3-D model-based object recognition, object fetching, and dynamic collision avoidance are successfully implemented.
Does Regular Breakfast Cereal Consumption Help Children and Adolescents Stay Slimmer? A Systematic Review and Meta-Analysis

Objective: To review systematically the evidence on breakfast cereal consumption and obesity in children and adolescents and assess whether the regular consumption of breakfast cereals could help to prevent excessive weight gain. Methods: A systematic review and meta-analysis of studies relating breakfast cereal consumption to BMI, BMI z-scores and prevalence of obesity as the outcomes. Results: 14 papers met the inclusion criteria. The computed effect size for mean BMI between high consumers and low or non-consumers over all 25 study subgroups was -1.13 kg/m2 (95% CI -0.81, -1.46, p < 0.0001) in the random effects model, which is equivalent to a standardised mean difference of 0.24. Adjustment for age and publication bias attenuated the effect sizes somewhat but they remained statistically significant. The prevalence and risk of overweight was lower in children and adolescents who consume breakfast cereals regularly compared to those who consume them infrequently. Energy intakes tended to be higher in regular breakfast cereal consumers. Conclusion: Overall, the evidence reviewed is suggestive that regular consumption of breakfast cereals results in a lower BMI and a reduced likelihood of being overweight in children and adolescents. However, more evidence from long-term trials and investigations into mechanisms is needed to eliminate possible confounding factors and determine causality.
Cortisol and testosterone in Filipino young adult men: Evidence for co‐regulation of both hormones by fatherhood and relationship status

Although cortisol (CORT) may suppress testosterone (T) production under stress, in many species males' T and CORT are co‐elevated during mate acquisition or conspecific competition. It is presently unknown how CORT co‐varies with T in relation to fatherhood/relationship status in men. Here we evaluate associations between waking (AM) and pre‐bed (PM) salivary CORT and T, and with plasma total T and luteinizing hormone. We also test whether co‐elevationor co‐downregulation of CORT and T are present in men who are mating‐oriented (non‐pairbonded, non‐fathers) and parenting‐oriented (pairbonded and/or fathers), respectively.
Determinants of CD4+ T cell recovery during suppressive antiretroviral therapy: association of immune activation, T cell maturation markers, and cellular HIV-1 DNA.

BACKGROUND Suboptimal CD4+ T cell recovery during antiretroviral therapy (ART) is a common clinical dilemma. METHODS We analyzed viral and immunologic predictors of CD4+ T cell recovery in 116 human immunodeficiency virus type 1 (HIV-1)-infected subjects who had suppressed viremia (< or = 50 copies/mL) while receiving ART. Successive measurements of T cell immunophenotypes and cellular HIV-1 DNA levels were obtained before and during receipt of ART. On the basis of increases in the CD4+ T cell count, subjects were classified as immunologically concordant (demonstrating an increase of > or = 100 CD4+ T cells/mm3) or discordant (demonstrating an increase of <100 CD4+ T cells/mm3) after 48 weeks of ART. RESULTS In adjusted analyses, CD4+ and CD8+ T cell activation at baseline was negatively associated with immunologic concordance at week 48 of ART (odds ratio [OR], 0.80 [P = .04] and 0.67 [P = .02], respectively). High memory (CDRA(-)CD62L-) CD8+ T cell counts at baseline (OR, 0.33 [P = .05]) predicted less CD4+ T cell recovery, whereas increased naive CD4+ T cell counts were associated with higher increases in CD4+ T cells (OR, 1.19 [P = .052]). Neither the cell-associated HIV-1 DNA level at baseline (P = .32) nor the cell-associated HIV-1 DNA level at week 48 of ART (P = .42) was associated with immunologic concordance during ART. CONCLUSIONS These results support the potential clinical usefulness of the baseline determination of immune activation and maturation subsets in the prediction of CD4+ T cell recovery during viral suppression. Furthermore, identification of individuals with reduced potential for CD4+ T cell recovery during ART may provide a rationale for the initiation of early therapy for some patients.
Women in Ireland’s Information Industry: Voices from Inside

during the past three decades Ireland has been undergoing signiWcant change. In the economic realm, makers of industrial policy have attempted to move the economy away from dependence upon agriculture and toward the development of new, growth industries identiWed as chemicals, pharmaceuticals, and information technology.1 The information technology industry—the focus of this article—consists of Wrms engaged in the manufacture of computer and telecommunications equipment, the development of computer software and information systems, and the provision of computer-related services. Because such highly industrialized countries as the United States were far ahead of Ireland in this industry, Irish policy-makers adopted a outward-looking strategy to help the country catch up. Beginning in the early 1970s the Industrial Development Authority began to invite multinational information technology companies to Ireland. Generous Wnancial incentives were oVered to attract these companies, especially to regions in the West. Two types of beneWts were expected to result from this strategy. The Wrst expected beneWt would be immediate. The Irish economy would improve as the unemployment and emigration rates declined through this infusion of new jobs. The second beneWt would be longer term. By working in these foreign Wrms, it was believed that Irish information technology workers would develop the business knowledge and technical expertise needed to establish their own Irish Wrms.
A prospective study of association of herpes simplex virus and human papillomavirus infection with cervical neoplasia in women exposed to diethylstilbestrol in utero

One thousand one hundred thirty‐four women, enrolled in a prospective study of the development of cervical neoplasia in women exposed to diethylstilbestrol (DES) in utero, were examined at least once a year. Twenty‐three women developed cervical intraepithelial neoplasia (CIN) of different degrees during the 7‐year follow‐up period and were matched with women who did not develop CIN during the study period. Serum samples were obtained at the time of entry into the study and at the time of diagnosis of neoplasia. In the control group, a second serum sample was obtained close to the time when CIN was diagnosed in the other group of women. The sera were studied for antibodies to both types of herpes simplex virus (HSV) by microneutralization assay and by a radioimmunoassay using, as antigens, glycoproteins VPI23 for HSV type I and VPII9 for HSV type 2. Women who developed CIN had, in the enrolment specimen which preceded the neoplasia, a higher rate of antibodies to HSV‐1 than did the matched controls (22%), while the two groups did not differ in frequency of antibodies to HSV‐2 (9%). Similar differences were observed in the samples drawn at the time of diagnosis of CIN. Women who later developed CIN and had, at the time of entry into the study, cervical epithelial changes associated with DES exposure, were infected with HSV‐1 at a higher rate than women who remained free of neoplasia or women with CIN but without DES‐associated cervical epithelial changes. Morphologic evidence of associated papillomavirus (HPV) infection was observed in 74% of CIN cases and no such observation was made in biopsy specimens taken prior to development of CIN. Morphologic evidence of HPV infection was found in a woman of the control group having squamous metaplasia. HPV structural antigens were found in 3 of 10 CIN I and CIN II cases, and none in the CIN III specimens. The possible role of the HSV and HPV infection in the pathogenesis of cervical neoplasia is discussed.
NEMATODE PARASITES FROM BURCHELL'S ZEBRAS IN SOUTH AFRICA

Twenty-five Burchell's zebras (Equus burchelli antiquorum) which were culled at monthly intervals in the Kruger National Park were examined for helminths. Twenty-nine species of nematodes belonging to the families Atractidae, Habronematidae, Onchocercidae, Oxyuridae, Strongylidae, Strongyloididae and Trichostrongylidae were recovered. The cyathostomes (small strongyles) most abundant were Cyathostomum tetracanthum, Cylicostephanus calicatus, Cylindropharynx sp. (? C. intermedia Theiler, 1923) and Cylicocyclus auriculatus. Cyathostomum alveatum, Cyathostomum montgomeryi, Cylicostephanus calicatus and Cylindropharynx sp. (? C. intermedia Theiler, 1923) were the most prevalent cyathostomes (small strongyles) while Craterostomum acuticaudatum was the most prevalent of the large strongyles. Of all the species recovered those most abundant were Crossocephalus viviparus and Probstmayria vivipara with intensities of 100 to 3,857,772 and 18,400 to 104,120,467, respectively. Four new species, two Triodontophorus spp. (Strongylidae) and two Habronema spp. (Habronematidae) were identified. Furthermore, this study furnishes a first report of Triodontophorus minor in zebras. The fourth stage cyathostomes as well as the adults of 11 of the 14 species were present in significantly greater intensities in autumn and winter.
Comparison of Bos taurus-Bos indicus breed crosses with straightbred Bos indicus breeds of cattle for maternal and individual traits.

Data were analyzed to compare crossbred females produced by crossing exotic Angus and Red Poll males to indigenous Ankole, Boran and Small East African Zebu (Zebu) females with straightbred females of the Ankole, Boran and Zebu breeds at the Ruhengere Field Station in the Ankole District of Southwestern Uganda. Progeny of the straightbred and crossbred dams were by Friesian, Brown Swiss and Simmental sires. Crossbred exotic X indigenous dams were favored over straightbred indigenous dams by 13.7% (P less than .01) in calf birth weight and by 14.8% (P less than .01) in calf weaning weight. Cross-bred cows exceeded (P less than .01) straightbred cows by 61.9% (48.5 kg) in calf weight weaned per cow exposed to breeding. Crossbred cows weighed 37, 46 and 42 kg more (P less than .01) than straightbred cows at parturition, weaning and cow mean weight, respectively. Angus X Boran and Red Poll X Boran crossbred dams were compared specifically with straightbred Boran dams. Exotic (Angus, Red Poll) X Boran crossbred dams exceeded straightbred Boran dams by 27.0% (P less than .05) in calf crop born, by 8.3% (P less than .05) in progeny birth weight and by 14.7% (P less than .01) in progeny weaning weight. Weight of calf weaned per cow exposed to breeding favored (P less than .01) the Angus X Boran and Red Poll X Boran crossbred dams over the straightbred Boran dams by 50.5% (50 kg). (ABSTRACT TRUNCATED AT 250 WORDS)
Ectopically Expressed Human Tumor Biomarker MutS Homologue 2 Is a Novel Endogenous Ligand That Is Recognized by Human γδ T Cells to Induce Innate Anti-tumor/Virus Immunity*

Background: Ectopically expressed hMSH2 is a tumor biomarker; however, the mechanism of its recognition is unclear. Results: hMSH2 interacted with both TCRγδ and NKG2D on Vδ2 T cells, resulting in Vδ2 T cell activation. Its expression was up-regulated by EBV infection. Conclusion: hMSH2 is a ligand for TCRγδ and NKG2D. Significance: Recognition of hMSH2 by γδ T cells induces innate anti-tumor/virus immunity. Human (h) MutS homologue 2, a nuclear protein, is a critical element of the DNA mismatch repair system. Our previous studies suggest that hMSH2 might be a protein ligand for TCRγδ. Here, we show that hMSH2 is ectopically expressed on a large panel of epithelial tumor cells. We found that hMSH2 interacts with both TCRγδ and NKG2D and contributes to Vδ2 T cell-mediated cytolysis of tumor cells. Moreover, recombinant human MSH2 protein stimulates the proliferation and IFN-γ secretion of Vδ2 T cells in vitro. Finally, hMSH2 expression is induced on the cell surface of Epstein-Barr virus-transformed lymphoblastoid cell lines, and the induction increases the sensitivity of these lymphoblastoid cell lines to γδ T cell-mediated cytolysis. Our data suggest that hMSH2 functions as a tumor-associated or virus infection-related antigen recognized by both Vδ2 TCR and NKG2D, and it plays a role in eliciting the immune responses of γδ T cells against tumor- and virus-infected cells. The recognition of ectopic surface-expressing endogenous antigen by TCRγδ and NKG2D may be an important mechanism of innate immune response to carcinogenesis and viral infection.