Miracle-dz/UniFAR-FTUs huggingface dataset:
Development , Elder Abuse and Quality of Life : Older women in Urban India

Often, ‘development’ is simplistically equated to economic growth, however, philosophically it has a deeper meaning that points towards improvement of humankind. The implicit meaning entailed in ‘improvement of mankind’ is ‘increasing the lifespan’ as well as ‘quality of life’ of people. With economic development and technological advancements, life expectancy at birth in India has almost doubled in the last five decades and continues to increase. However, with the changing socio-cultural context and weakening inter-generational bonds, the value system of filial piety is rapidly fading. These changes have led to increased incidence of elder abuse and neglect, especially within the family, that adversely affects the quality of lives of older persons, more so, for older women. Older women are more vulnerable due to inadequate access to resources, and dependence on their spouse and family to meet their basic needs during their life course. This paper highlights the types of abuse experienced by older women in an urban context in India, and its influence on various dimensions and overall quality of their life. The data from a cross-sectional survey conducted in suburbs of Mumbai, India, has been used to meet the objectives of this study in addition to review from other empirical studies in Indian context. The findings show a high incidence of elder abuse and family members being the main perpetrators. Elder abuse had a significantly negative impact on all dimensions of quality of life of older women reflecting an urgent need for change in social attitude coupled with policy and programmatic interventions.
Strain Adaptive Bone Remodelling in Total Joint Replacement

Histomorphologic analyses of artificial joint components implanted into bone need special technology for processing and for documentation; published histological work systematically done therefore is rare. The histopathology, three-dimensionally analyzed in a complete sequence of sections is, however, the only precise answer in terms of biocompatibility and bone response. A complete analysis allows a type-related predictable prognosis of an implantation that is at least comparable to a finite element analysis with respect to load transfer to host bone. The histopathologic collection of the ZOW Munich is comprised of more than 5000 nondemineralized bone and joint specimens and more than 500 artificial joint components implanted in the human skeleton for up to 25 years. Fifty-nine implant-bone specimens without signs of loosening already have been processed and analyzed systematically. According to the strain-adapted bone remodelling, different types of anchorage clearly were differentiated and their morphologic substrate could be worked out. Based on that, the cemented standard anchorage could be distinguished histologically from the cemented press-fit procedure, and the noncemented press-fit from the porous ingrowths pattern. In terms of the topography of the bony integration, the proximal and distal press-fit and ingrowth pattern were analyzed; beside that, the cemented and noncemented epiphyseal resurfacings could be defined histologically. In all histologic specimens the remodelling appeared as a result of stress-related strain, reflecting stiffness of the implant and the resistance of bone to deformation. It clearly was worked out that all success of cemented components is based on preserved cancellous bone honeycombs stiffened by bone cement, representing an adaptation of bone in terms of stiffness to the stiff implants.
Self-directed Learning and English Proficiency by Korean Learners* 1

Korean The study investigates to what extent a commitment to and a self-evaluation of a specific self-directed learning activity explain Korean college students’ EFL proficiency (using TOEIC reading scores). Of the Korean college students who participated, 52 completed log writing of self-directed learning activities, and 44 completed a self-evaluating survey and submitting a TOEIC reading score. Through statistical analyses, including correlations and regressions, the study finds that the number of minutes spent on reading aloud explained 10% of the variances of participants’ TOEIC reading scores. Another finding of the study is that perceived effectiveness of note-taking for grammar learning on listening and perceived manageability of reading aloud explained 21% of the variances in TOEIC reading scores. On the basis of these results, the study proposes that commitment to reading aloud and learner-perceived effectiveness of note-taking for grammar learning on listening can function as significant predictors for EFL reading proficiency. Several practical suggestions are provided for EFL instructors and researchers for the more effective use of self-directed learning activities and self-evaluation results. in self-reflection.
Children ’ s Knowledge of Conventional Implicatures : Evidence from the Mandarin lian ... dou Construction

Children’s understanding of conversational implicatures, scalar implicature in particular, has been extensively investigated (see Papafragou & Skordos 2016 for a recent comprehensive review). It has been reported that children do not often have adult-like pragmatic inferences in dealing with tasks that involve information strength in uncontrolled experimental environments. However, little has been shown about children’s knowledge of conventional implicatures that arise from the semantic meanings of particular words, such as even. In Karttunen and Peters’ (1979) analysis, even can trigger two implicatures, one an existential implicature (that alternatives exist), and one a scalar implicature 1(that the mentioned alternative is the least likely). This study focuses on the lian.dou construction in Mandarin, which can be used in two distinct contexts. In one context (the two-implicature context), it is equivalent to an English even-sentence, where even is considered to be the focus marker and the whole sentence sometimes indicates certain unexpectedness or surprise. In general, the comprehension of such unexpectedness or surprise requires the listener to generate both the existential implicature and the scalar implicature. In the other context (the one-implicature context), lian.dou only gives rise to the existential implicature. By comparing the two uses of lian.dou, the scalar implicature can be isolated from the existential implicature, and allows an investigation of their development in child language.
Probing quasifission in reactions forming 210 Rn nucleus

A. Shamlath∗,1, E. Prasad1,†, N. Madhavan2, P. V. Laveen1, J. Gehlot2, A. K. Nasirov3,‡, G. Giardina4, G. Mandaglio5,§, S. Nath2, Tathagata Banerjee2, A. M. Vinodkumar6, M. Shareef1, A. Jhingan2, T. Varughese2, DVGRKS Kumar7, P. Sandya Devi7, Khushboo8, P. Jisha6, Neeraj Kumar8, M. M. Hosamani9, and S. Kailas10 1Department of Physics, School of Physical Sciences, Central University of Kerala, Kasaragod
Revision 1 1 Equation of state of the high-pressure Fe 3 O 4 phase and a new structural 2 transition at 70 GPa 3

10 We have investigated the high-pressure behavior of Fe3O4 by in situ X-ray diffraction 11 measurements from 11 to 103 GPa. Up to 70 GPa, the previous observed high-pressure Fe3O4 12 phase (h-Fe3O4) is stable, with a CaTi2O4-type structure. The compression curve shows an 13 abnormal volume contraction at about 50 GPa, likely associated with the magnetic moment 14 collapse observed at that pressure. Fitting the compression data up to 45 GPa to the Birch15 Murnaghan equation of state yields a bulk modulus, KT0= 172 GPa, and V0 = 277 Å, with 16 fixed K’ = 4. At a pressure between 64 and 73 GPa, a new structural transition was observed 17 in Fe3O4, which can be attributed to a martensitic transformation as described by Yamanaka et 18 al. (2008) for post-spinel structural transition. The diffraction data can be best fitted with a 19 Pnma space group. No breakdown of Fe3O4 was observed up to at least 103 GPa. The new 20 high-pressure polymorph is about 6% denser than the h-Fe3O4 phase at 75 GPa. 21
Semantic bias in the acquisition of relative clauses in Japanese*

ABSTRACT This study analyzes the acquisition of relative clauses in Japanese to determine the semantic and functional characteristics of children's relative clauses in spontaneous speech. Longitudinal data from five Japanese children are analyzed and compared with English data (Diessel & Tomasello, 2000). The results show that the relative clauses produced by Japanese children predominantly have stative/attributive predicates. Additionally, early relative clauses in Japanese are often used to identify a referent that is not present in the context of interaction. These findings contrast with Diessel & Tomasello's (2000) English data, and possible explanations include the input that children are exposed to, which reflects typological characteristics of noun modification in Japanese.
Surfing the internet with a BCI mouse

In this paper, we present a new web browser based on a two-dimensional (2D) brain–computer interface (BCI) mouse, where our major concern is the selection of an intended target in a multi-target web page. A real-world web page may contain tens or even hundreds of targets, including hyperlinks, input elements, buttons, etc. In this case, a target filter designed in our system can be used to exclude most of those targets of no interest. Specifically, the user filters the targets of no interest out by inputting keywords with a P300-based speller, while keeps those containing the keywords. Such filtering largely facilitates the target selection task based on our BCI mouse. When there are only several targets in a web page (either an original sparse page or a target-filtered page), the user moves the mouse toward the target of interest using his/her electroencephalographic signal. The horizontal movement and vertical movement are controlled by motor imagery and P300 potential, respectively. If the mouse encounters a target of no interest, the user rejects it and continues to move the mouse. Otherwise the user selects the target and activates it. With the collaboration of the target filtering and a series of mouse movements and target selections/rejections, the user can select an intended target in a web page. Based on our browser system, common navigation functions, including history rolling forward and backward, hyperlink selection, page scrolling, text input, etc, are available. The system has been tested on seven subjects. Experimental results not only validated the efficacy of the proposed method, but also showed that free internet surfing with a BCI mouse is feasible.
Srs2 DNA helicase is involved in checkpoint response and its regulation requires a functional Mec1‐dependent pathway and Cdk1 activity

In Saccharomyces cerevisiae the rate of DNA replication is slowed down in response to DNA damage as a result of checkpoint activation, which is mediated by the Mec1 and Rad53 protein kinases. We found that the Srs2 DNA helicase, which is involved in DNA repair and recombination, is phosphorylated in response to intra‐S DNA damage in a checkpoint‐dependent manner. DNA damage‐induced Srs2 phosphorylation also requires the activity of the cyclin‐dependent kinase Cdk1, suggesting that the checkpoint pathway might modulate Cdk1 activity in response to DNA damage. Moreover, srs2 mutants fail to activate Rad53 properly and to slow down DNA replication in response to intra‐S DNA damage. The residual Rad53 activity observed in srs2 cells depends upon the checkpoint proteins Rad17 and Rad24. Moreover, DNA damage‐induced lethality in rad17 mutants depends partially upon Srs2, suggesting that a functional Srs2 helicase causes accumulation of lethal events in a checkpoint‐defective context. Altogether, our data implicate Srs2 in the Mec1 and Rad53 pathway and connect the checkpoint response to DNA repair and recombination.
Fascin expression predicts lymph node metastasis and worse survival in small intestinal carcinoma

Summary Fascin expression has been associated with clinicopathological parameters and clinical outcome in many carcinomas. The aim of this study was to evaluate the prognostic impact of fascin expression in small intestinal carcinomas (SICs). We constructed tissue microarrays for evaluation of immunohistochemical expression of fascin in a total of 194 SICs. Fascin was expressed in 47 (24.2%) of the 194 SICs, and fascin expression showed an association with poorly and undifferentiated histology (p < 0.001) and lymphatic invasion (p = 0.019). No fascin expression was observed in tumour cells of metastatic lymph nodes in cases of SIC without fascin expression (p < 0.001). Patients with fascin expression showed significantly shorter overall survival compared to patients without expression (p = 0.001). In multivariate analysis, fascin expression was an independent prognostic factor in SIC patients (p = 0.043). Fascin expression showed significant correlation with lack of differentiation and lymphatic invasion, and may be a useful predictive marker for lymph node metastasis. Fascin expression in SICs showed an association with poor overall survival and was an independent poor prognostic factor.
Genome Analysis of a Mycoplasma hyorhinis Strain Derived from a Primary Human Melanoma Cell Line

ABSTRACT The complete genome of Mycoplasma hyorhinisstrain MCLD has been sequenced and annotated. This genome differs by the inversion of a 14.4-kb and a 3.7-kb fragment and the deletion of a 9.9-kb fragment from M. hyorhinisstrain HUB-1, isolated from swine respiratory tract. The genome revealed 778 coding sequences (CDSs), with a limited number of vlpgenes encoding variable surface lipoproteins.
Chromosomal translocations and karyotype complexity in chronic lymphocytic leukemia: A systematic reappraisal of classic cytogenetic data

The significance of chromosomal translocations (CTRAs) and karyotype complexity (KC) in chronic lymphocytic leukemia (CLL) remains uncertain. To gain insight into these issues, we evaluated a series of 1001 CLL cases with reliable classic cytogenetic data obtained within 6 months from diagnosis before any treatment. Overall, 320 cases were found to carry ≥1 CTRAs. The most frequent chromosome breakpoints were 13q, followed by 14q, 18q, 17q, and 17p; notably, CTRAs involving chromosome 13q showed a wide spectrum of translocation partners. KC (≥3 aberrations) was detected in 157 cases and significantly (P < 0.005) associated with unmutated IGHV genes and aberrations of chromosome 17p. Furthermore, it was identified as an independent prognostic factor for shorter time‐to‐first‐treatment. CTRAs were assigned to two categories (i) CTRAs present in the context of KC, often with involvement of chromosome 17p aberrations, occurring mostly in CLL with unmutated IGHV genes; in such cases, we found that KC rather than the presence of CTRAs per se negatively impacts on survival; (ii) CTRAs in cases without KC, having limited if any impact on survival. On this evidence, we propose that all CTRAs in CLL are not equivalent but rather develop by different processes and are associated with distinct clonal behavior. Am. J. Hematol. 89:249–255, 2014. © 2013 Wiley Periodicals, Inc.
Protein Kinase C is a Target for Diverse Developmental Neurotoxicants : Transcriptional Responses to Chlorpyrifos , Diazinon , Dieldrin and Divalent Nickel in PC 12 Cells

Unrelated developmental neurotoxicants can elicit similar functional outcomes, whereas agents in the same class may differ. We compared two organophosphate insecticides (chlorpyrifos, diazinon) with an organochlorine (dieldrin) and a metal (Ni2+) for similarities and differences in their effects on gene expression encoding subtypes of protein kinase C and their modulators, a cell signaling cascade that integrates the actions of neurotrophic factors involved in brain development. We conducted evaluations in PC12 cells, a model for neuronal development, with each agent introduced at 30 μM for 24 or 72 hr, treatments devoid of cytotoxicity. Chlorpyrifos evoked by far the largest effect, with widespread upregulation of multiple genes; the effects were greater during neurodifferentiation than when cells were exposed prior to differentiation. Diazinon had smaller and less widespread effects, consistent with its lesser long-term impact on synaptic function and behavior noted for in vivo exposures in developing rats. Surprisingly, the effects of diazinon, dieldrin and Ni2+ showed basic similarities despite the fact that all three come from different classes of toxicants. Our findings provide some of the first evidence for a specific mechanistic cascade contributing to the cholinesterase-independent developmental neurotoxicant actions of chlorpyrifos and its differences from diazinon, while at the same time identifying mechanistic convergence between otherwise unrelated toxicants that provide predictions about common neurodevelopmental outcomes. These results further show how combined use of cell cultures and microarray technology can guide future in vivo work on diverse developmental neurotoxicants.
Is α‐Methyl‐l‐Tryptophan a Good Tracer for Brain Serotonin Synthesis Measurements, and Does the Lumped Constant Vary in Different Structures of the Rat Brain?

To the Editors: We have read with great interest the recent article by Gharib et al. (1999) published in this journal. Their experiments replicate and extend earlier findings related to the use of labeled a-methyl-L-tryptophan (a-MTrp) as the tracer for measuring rates of 5hydroxytryptamine (serotonin; 5-HT) synthesis in brain. Gharib et al. (1999), however, calculated the lumped constant ( LC) differently from how it had been proposed in the original model (Vanier et al., 1995), and, as a consequence, their LC and rates of 5-HT synthesis differ from previous reports (see, e.g., Nagahiro et al., 1990; Tsuiki et al., 1995; Vanier et al., 1995; Mu ̈ck-Šeler and Diksic, 1996; Mu ̈ck-Šeler et al., 1996; Okazawa et al., 1999). Once the apparent difference in theLC is corrected for (see below), the rates of 5-HT synthesis presented by Gharib et al. (1999) in Table 4 are very similar to those reported by us. These results are also similar to those obtained using labeled tryptophan (Trp) as a tracer (Table 3 in Vanier et al., 1995). This suggests that estimates of 5-HT synthesis obtained by different approaches agree well with those reported by us using labeled a-MTrp as a tracer. The a-MTrp model, as originally proposed (Diksic et al., 1990; Vanier et al., 1995), assumes the transfer of labeleda-MTrp and/or its metabolite into an irreversible compartment, not necessarily a biochemical conversion to labeleda-methylserotonin ( a-M5HT). Any conversion of the tracer toa-M5HT is greatly hindered by the facts that theKm for Trp is lower than that ofa-MTrp (Gal and Christiansen, 1975; Schirlin et al., 1988) and that the tracer’s concentration in brain is ;1,900 less than that of Trp (Gharib et al., 1999). Consequently, our model has been derived to measure the transfer of labeleda-MTrp to an irreversible tissue compartment ( K; in ml/g/min) and uses the LC to convertK to the transfer constant for Trp via the 5-HT biosynthetic pathway ( K; in ml/g/min) (Vanier et al., 1995). The latter is then used in the calculation of 5-HT synthesis rates (Diksic et al., 1990; Nagahiro et al., 1990). We have definedLCv (Vanier et al., 1995) as a ratio betweenK and K (uptake constants for a-MTrp and Trp, respectively). As Gharib et al. (1999) note, the free fractions of the tracer for a-MTr ( f ) and Trp (f ) in the plasma differ substantially. Unlike for Gharib et al. (1999), however, this difference in protein binding is implicitly included in our calculation of theLCv. This can be seen from our formulation of LCv, assuming for simplicity in this derivation no difference in the plasma free Trp concentration between experiments with Trp anda-MTrp.
Demographic Characteristics of Punching Glass Patients ’ and Related to Weather Conditions

ÖZ Objective: The aim of the present study was to determine the preventive effects of piracetam on testes against to oxidative damage which induced by ischemia/reperfusion. Material and Methods: The rats randomly divided to 4 groups. Group 1 was considered as control/sham, Group 2 was I/R (Ischemia/Reperfusion), Group 3 was piracetam (250 mg/kg; i.p.) + I/R and Group 4 was piracetam (500 mg/kg; i.p.) + I/R. Piracetam was given intraperitoneally (i.p) after 60 mins of testicular torsion. In all 4 groups, the ipsilateral (left testis) and contralateral testes (right testis) of rats were excised 6 hours after beginning of the procedure. Results: Piracetam administration significantly increased total antioxidant capacity and decreased oxidative stress index. There was no statistically difference according to Johnsen’s scoring system among the groups in the ipsilateral or contralateral testes. Conclusion: Piracetam administration decreased oxidative damage which induced by ischemia/reperfusion in testes via increasing antioxidant activity and decreasing oxidative stres scores. However, the treatment was not induced alteration in histopathological examination and spermatogenesis scores. Amaç: Çalışmamızda amacımız, testiste iskemi/reperfüsyon (I/R) etkisi ile oluşan oksidatif hasar üzerine pirasetamın koruyucu etkilerini araştırmaktır. Gereç ve Yöntemler: Ratlar rastgele 4 gruba ayrıldı. Grup 1= sham (kontrol), Grup 2=I/R (iskemi/reperfüsyon), Grup 3=I/R+pirasetam (250 mg/kg; i.p.) ve Grup 4=I/R+pirasetam (500 mg/kg; i.p.). Pirasetam intraperitoneal yolla testis torsiyonunu takiben 60. dakikada verilmiştir. Her 4 grupta işlemin başlangıcından 6 saat sonra ipsilateral sol testis ve kontralateral sağ testisler çıkarılmıştır. Bulgular: Pirasetam uygulaması total antioksidan kapasiteyi istatistiksel olarak anlamlı biçimde arttırırken, oksidatif stres indeks oranını da istatistiksel olarak anlamlı biçimde azaltmıştır. İpsilateral ve kontralateral testis grupları arasında Johnsen skorlama sistemine göre istatistiksel farklılık saptanmamıştır. Sonuç: Pirasetam uygulaması, testislerde iskemi reperfüzyon ile oluşan oksidatif hasarı antioksidan kapasiteyi arttırarak ve oksidatif stres skorlarını düşürerek azaltmıştır; ancak, histopatolojik incelemede ve spermatogenes skorlarında bir değişime neden olmamıştır.
Informational Herding by Institutional Investors : Evidence from Analyst Recommendations

We study daily institutional herding levels around the release of sell-side analyst recommendations. Such recommendations are forward-looking and indicate unambiguous direction of trades thus providing a good scenario to investigate informational herding behavior. We find that institutional herding on the recommendation release date is short-lived and specific to high turnover stocks suggesting that institutional investors herd during periods of significant disagreement. We do not find that institutional herding around recommendations destabilizes prices, but rather herding helps to speed up the information incorporated into stock prices. Consistent with investigative herding models, our results suggest that institutional investors herd upon the arrival of correlated information signals, and that such action improves market efficiency. This is in clear contrast with non-informational herding models, which are associated with subsequent return reversals.