Miracle-dz/UniFAR-FTUs huggingface dataset:
Tsunami-driven rafting: Transoceanic species dispersal and implications for marine biogeography

Long-distance life rafting When coastal ecosystems are affected by storms or tsunamis, organisms can be rafted across oceans on floating debris. However, such events are rarely observed, still less quantified. Carlton et al. chart the rafting journeys of coastal marine organisms across the Pacific Ocean after the 2011 East Japan earthquake and tsunami (see the Perspective by Chown). Of the nearly 300 mainly invertebrate species that reached the shores of the U.S. Pacific Northwest, most arrived attached to the remains of manmade structures. Science, this issue p. 1402; see also p. 1356 Two hundred seventy-nine coastal marine species have been recorded crossing the Pacific by rafting after the 2011 East Japan tsunami. The 2011 East Japan earthquake generated a massive tsunami that launched an extraordinary transoceanic biological rafting event with no known historical precedent. We document 289 living Japanese coastal marine species from 16 phyla transported over 6 years on objects that traveled thousands of kilometers across the Pacific Ocean to the shores of North America and Hawai‘i. Most of this dispersal occurred on nonbiodegradable objects, resulting in the longest documented transoceanic survival and dispersal of coastal species by rafting. Expanding shoreline infrastructure has increased global sources of plastic materials available for biotic colonization and also interacts with climate change–induced storms of increasing severity to eject debris into the oceans. In turn, increased ocean rafting may intensify species invasions.
Modulation of Platelet Activation in Chronic Kidney Disease Patients on Erythropoiesis-Stimulating Agents

Background: Clinical trials demonstrate either no benefit or increased risk of cardiovascular events and mortality in patients with chronic kidney disease (CKD) targeted for higher hemoglobin levels, who are treated with erythropoiesis-stimulating agents (ESAs). The mechanism underlying this observation remains unexplained. Methods and Results: We assessed platelet activation by measuring soluble P-selectin (sPsel), CD40 ligand (CD40L), and circulating microparticles (CMP) in patients with CKD. Higher hemoglobin levels were associated with increased Psel levels in patients on ESAs but not in ESA-naïve anemic and nonanemic patients. Psel positively correlated with CMP and CD40L in both anemic and nonanemic patients. Multivariate linear regression analysis revealed an association between increased Psel levels and hemoglobin concentration in patients receiving ESAs. Conclusions: Anemic CKD patients on ESAs demonstrate increased levels of markers of platelet activation. These observations suggest a potentially complex interplay between platelet activation, impaired kidney function, and treatment of CKD anemia with ESAs.
An Efficient SVD-Based Method for Image Denoising

Nonlocal self-similarity of images has attracted considerable interest in the field of image processing and has led to several state-of-the-art image denoising algorithms, such as block matching and 3-D, principal component analysis with local pixel grouping, patch-based locally optimal wiener, and spatially adaptive iterative singular-value thresholding. In this paper, we propose a computationally simple denoising algorithm using the nonlocal self-similarity and the low-rank approximation (LRA). The proposed method consists of three basic steps. First, our method classifies similar image patches by the block-matching technique to form the similar patch groups, which results in the similar patch groups to be low rank. Next, each group of similar patches is factorized by singular value decomposition (SVD) and estimated by taking only a few largest singular values and corresponding singular vectors. Finally, an initial denoised image is generated by aggregating all processed patches. For low-rank matrices, SVD can provide the optimal energy compaction in the least square sense. The proposed method exploits the optimal energy compaction property of SVD to lead an LRA of similar patch groups. Unlike other SVD-based methods, the LRA in SVD domain avoids learning the local basis for representing image patches, which usually is computationally expensive. The experimental results demonstrate that the proposed method can effectively reduce noise and be competitive with the current state-of-the-art denoising algorithms in terms of both quantitative metrics and subjective visual quality.
Mean Platelet Volume and Related Factors in Patients at Different Stages of Diabetic Nephropathy

Introduction: Mean platelet volume (MPV) is an independent cardiovascular disease predictor, and characteristics of MPV in patients with diabetic nephropathy (DN) are not well known. Aim: To determine the MPV levels in patients at different stages of DN. Patients and Methods: The MPV levels were investigated in healthy participants (group 1, n = 157), patients with type 2 diabetes mellitus without complication (group 2, n = 160), diabetic patients with clinical proteinuria (group 3, n = 144), and in patients with chronic kidney disease due to DN (group 4, n = 160). Findings: The MPV level was higher in all diabetic patients than that in normal participants (P < .05). The MPV values had a positive correlation with the serum creatinine and proteinuria, and a negative correlation with the glomerular filtration rate ([GFR] P < .001 for all, r values; .72, and .82, and −.92, respectively). Conclusion: The MPV values were higher in diabetic groups than that in normal participants. Both GFR and proteinuria were the most powerful determinants of MPV.
Hyperhomocysteinemia and Methylenetetrahydrofolate Reductase C677T Polymorphism in Cerebral Veno-sinus Thrombosis

There is limited data on the role of hyperhomocysteinemia as a risk factor for cerebral veno-sinus thrombosis (CVT) in Indians. We examined the association between plasma homocysteine (Hcy), methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, and CVT in 185 patients with aseptic CVT (puerperal 80 and nonpuerperal 105) and 248 healthy controls (puerperal 67 and nonpuerperal 181). Fasting Hcy was higher in patients compared to controls (20.25 ± 5.97 vs 9.81 ± 5.19 μmol/L, P < .001) and associated with 4.54-fold (95% confidence interval [CI]: 2.74-7.53) increase in risk of CVT. Risk was higher in puerperal (odds ratio [OR]: 8.7, 95% CI: 2.73-26.91) compared to nonpuerperal CVT (OR: 3.82, 95% CI: 2.09-6.96). Plasma Hcy was higher in MTHFR 677TT compared to 677CT and 677CC genotypes (34.44 ± 32.8 vs 25.81 ± 33.3 vs 18.50 ± 23.7 μmol/L, respectively, P < .001), but the risk associated with MTHFR 677TT was insignificant (OR: 1.91, 95% CI: 0.53-7.06). We conclude that hyperhomocysteinemia is a risk marker for Indian patients with aseptic CVT. MTHFR 677TT genotype is not linked with CVT but is a determinant of plasma Hcy.
Mean Platelet Volume Associated With Aortic Distensibility, Chronic Inflammation, and Diabetes in Patients With Stable Coronary Artery Disease

We aimed to assess the effective factors on high mean platelet volume (MPV) in patients with stable coronary artery disease (CAD). A total of 411 patients (247 males and 164 females; mean age: 61.7 ± 9.9 years) with angiographically proven CAD were included. The patients were divided into 2 groups according to the median MPV value (MPVlow group <9.5 fL and MPVhigh group ≥9.5 fL). The SYNTAX score, high sensitive C-reactive protein (hsCRP) levels, and frequencies of diabetes and hypertension were higher in MPVhigh group compared to MPVlow group. Aortic distensibility (AD) and platelet count of patients in MPVhigh group were lower than patients in MPVlow group (P < .05, for all). Multivariate linear regression analysis showed that MPV was independently related with diabetes (β = 0.135, P = .007), hsCRP (β = 0.259, P < .001), platelet count (β = −0.144, P < .001), and AD (β = −0.425, P < .001). High MPV value is independently related to AD, as well as diabetes, hsCRP, and platelet count in patients with stable CAD.
Anticoagulation in Patients With Left Ventricular Systolic Dysfunction and Sinus Rhythm

Left ventricular (LV) systolic dysfunction and chronic systolic heart failure (HF) predispose to intraventricular thrombus formation and embolization resulting in stroke. Current guideline recommends the use of oral anticoagulants in patients with atrial fibrillation and history of previous thromboembolism. However, anticoagulant treatment in patients with LV systolic dysfunction with sinus rhythm and without history of previous thromboembolism is still on debate. Recent epidemiologic date has reported increased stroke rate in patients with systolic HF shortly after diagnosis. This review focuses on the possible causes of increased stroke rate shortly after the diagnosis of HF and subsequently suggests a rationale for the use of oral anticoagulant in these patient groups.
SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway

SAMTOR joins the family The amino acid methionine is widely appreciated to have interesting effects on animal physiology. Diets low in methionine increase longevity and overall health, particularly glucose homeostasis. Gu et al. describe a potential molecular link between the effects of methionine restriction and the growth controller mTOR complex 1 (mTORC1), a well-validated regulator of life span and health span in many organisms. They identify a protein that they named SAMTOR as a component of the nutrient-sensing pathway upstream of mTORC1. SAMTOR directly binds S-adenosylmethionine (SAM), a metabolite made from methionine, and is necessary for regulating mTORC1 in response to methionine. Science, this issue p. 813 SAMTOR is a SAM sensor that links methionine and one-carbon metabolism to mTORC1 signaling. mTOR complex 1 (mTORC1) regulates cell growth and metabolism in response to multiple environmental cues. Nutrients signal via the Rag guanosine triphosphatases (GTPases) to promote the localization of mTORC1 to the lysosomal surface, its site of activation. We identified SAMTOR, a previously uncharacterized protein, which inhibits mTORC1 signaling by interacting with GATOR1, the GTPase activating protein (GAP) for RagA/B. We found that the methyl donor S-adenosylmethionine (SAM) disrupts the SAMTOR-GATOR1 complex by binding directly to SAMTOR with a dissociation constant of approximately 7 μM. In cells, methionine starvation reduces SAM levels below this dissociation constant and promotes the association of SAMTOR with GATOR1, thereby inhibiting mTORC1 signaling in a SAMTOR-dependent fashion. Methionine-induced activation of mTORC1 requires the SAM binding capacity of SAMTOR. Thus, SAMTOR is a SAM sensor that links methionine and one-carbon metabolism to mTORC1 signaling.
Superpixel-Based Face Sketch–Photo Synthesis

Face sketch–photo synthesis technique has attracted growing attention in many computer vision applications, such as law enforcement and digital entertainment. Existing methods either simply perform the face sketch–photo synthesis on the holistic image or divide the face image into regular rectangular patches ignoring the inherent structure of the face image. In view of such situations, this paper presents a novel superpixel-based face sketch–photo synthesis method by estimating the face structures through image segmentation. In our proposed method, face images are first segmented into superpixels, which are then dilated to enhance the compatibility of neighboring superpixels. Each input face image induces a specific graphical structure modeled by Markov networks. We employ a two-stage synthesis process to learn the face structures through Markov networks constructed from two scales of dilation, respectively. Experiments on several public databases demonstrate that our proposed face sketch–photo synthesis method achieves superior performance compared with the state-of-the-art methods.
Colossal grain growth yields single-crystal metal foils by contact-free annealing

Turning many into one Single-crystal metal foils are valuable for their surface properties that allow for synthesis of materials like graphene. Jin et al. present a strategy for creating colossal single-crystal metal foils called “contact-free annealing” (see the Perspective by Rollett). The method relies on hanging and heating commercially available, inexpensive, cold-rolled metal foils. Almost as if by magic, the polycrystalline grains rotate and anneal into a large single-crystal sheet with a specific crystal orientation. The strategy allows for the creation of much larger and much cheaper single-crystal metal foils. Science, this issue p. 1021; see also p. 996 Contact-free annealing allows for the synthesis of large single-crystal metal foils. Single-crystal metals have distinctive properties owing to the absence of grain boundaries and strong anisotropy. Commercial single-crystal metals are usually synthesized by bulk crystal growth or by deposition of thin films onto substrates, and they are expensive and small. We prepared extremely large single-crystal metal foils by “contact-free annealing” from commercial polycrystalline foils. The colossal grain growth (up to 32 square centimeters) is achieved by minimizing contact stresses, resulting in a preferred in-plane and out-of-plane crystal orientation, and is driven by surface energy minimization during the rotation of the crystal lattice followed by “consumption” of neighboring grains. Industrial-scale production of single-crystal metal foils is possible as a result of this discovery.
Social place-cells in the bat hippocampus

The representation of others in space Different sets of neurons encode the spatial position and orientation of an organism. However, social animals need to know the position of other individuals for social interactions, observational learning, and group navigation. Surprisingly, very little is known about how the position of other animals is represented in the brain. Danjo et al. and Omer et al. now report the discovery of a subgroup of neurons in hippocampal area CA1 that encodes the presence of conspecifics in rat and bat brains, respectively. Science, this issue p. 213, p. 218 A subpopulation of bat hippocampal CA1 neurons represents the spatial position of another bat. Social animals have to know the spatial positions of conspecifics. However, it is unknown how the position of others is represented in the brain. We designed a spatial observational-learning task, in which an observer bat mimicked a demonstrator bat while we recorded hippocampal dorsal-CA1 neurons from the observer bat. A neuronal subpopulation represented the position of the other bat, in allocentric coordinates. About half of these “social place-cells” represented also the observer’s own position—that is, were place cells. The representation of the demonstrator bat did not reflect self-movement or trajectory planning by the observer. Some neurons represented also the position of inanimate moving objects; however, their representation differed from the representation of the demonstrator bat. This suggests a role for hippocampal CA1 neurons in social-spatial cognition.
Evaluation of 2 Nomogram-Based Strategies for Dosing Argatroban in Patients With Known or Suspected Heparin-Induced Thrombocytopenia

No study has compared 2 different dosing strategies for argatroban titration nor has any published nomogram demonstrated improvement in outcomes. This study was conducted to evaluate the effectiveness of 2 argatroban nomograms on reaching therapeutic anticoagulation. Patients treated with argatroban were separated into 2 sliding scale groups, percentage adjustments (PAs) and predefined dose increments (PDIs). The primary outcome was the time to reach a therapeutic activated partial thromboplastin time (aPTT). The average initial dose and dose to achieve a therapeutic aPTT were similar between the groups. There was also no difference in the number of dose changes. The time to reach a therapeutic aPTT was 2 hours shorter in the PDI compared to the PA group, 8 ± 4 hours versus 10 ± 4 hours, P = . 015. This study demonstrates a significant time advantage associated with a PDI nomogram compared to a PA nomogram but no difference with respect to the number of rate changes.
Sex Differences in Depressive Symptoms and Their Correlates After Mild-to-Moderate Traumatic Brain Injury

The purpose of this secondary data analysis, guided by allostatic load theory, was to compare depressive symptoms and their correlates in men and women following mild or moderate traumatic brain injury (n = 159). Using general linear modeling procedures in the Statistical Analysis Software, women reported significantly higher Center for Epidemiological Studies-Depression scores compared with men. According to the Neurobehavioral Functioning Inventory subscales, women also reported higher somatic and motor symptoms and difficulties with memory and cognition. Further, women within the first 6 months of their injury reported higher levels of depressive and depressive-somatic symptoms, perceived chronic stress, pain, memory difficulties, and somatic symptoms. These findings were no longer present at the 6- to 12-month or >12-month cutoffs. Women's depressive symptoms during the early recovery period are explained by higher symptom loads and perceived stress, yet mechanisms responsible for these differences remain to be elucidated. Future research is needed to describe hormonal, perceptual, or brain structure differences that may account for these findings. Findings from such research will most likely to contribute to our understanding of postconcussion syndrome.
Evaluation of Pediatric Bleeding Questionnaire in Turkish Children With Von Willebrand Disease and Platelet Function Disorders

The diagnosis of mild bleeding disorders is not easy as most of the “healthy” individuals also report bleeding symptoms. In order to get a precise bleeding history, Pediatric Bleeding Questionnaire (PBQ) has been developed. In our study, Turkish children diagnosed with Von Willebrand disease (VWD), platelet function defect (PFD), and healthy children without any symptoms (control group 1) and healthy children with symptoms but found hemostatically normal (control group 2) were analyzed with PBQ. The cut off level for “positive bleeding score” was found to be ≥2 (area under the curve [AUC]: 0.785, 95% confidence interval [CI]: 0.718-0.852). The sensitivity, specificity, positive predictive value, and negative predictive value of PBQ to define VWD versus control group 1 was 100%, 97.4%, 96.4%, and 100%; VWD versus control group 2 was 100%, 53.1%, 64.3%, and 100%; PFD versus control group 1 was 93.3%, 53.1%, 73.7%, and 85%; and PFD versus control group 2 was 93.3%, 53.1%, 73.7%, and 85%, respectively.
Video Stabilization for Strict Real-Time Applications

Offline or deferred solutions are frequently employed for high quality and reliable results in current video stabilization. However, neither of these solutions can be used for strict real-time applications. In this paper, we propose a practical and robust algorithm for real-time video stabilization. To achieve this, a novel and efficient motion model based on inter-frame homography estimation is proposed to represent the video motion. An important feature of the proposed motion model is that it updates at each frame input to reduce the accumulation errors caused by parallax or scene changes. We also propose a novel Kalman filter for the motion smoothing and a unique mosaic algorithm for the video completion. The proposed Kalman filter and mosaic algorithm enable the development of a practical real-time video stabilizer that not only produces steady video but also retains the full resolution of the original video. We verify the proposed algorithm through a broad range of video sequences that demonstrate that the proposed algorithm is computationally efficient while being able to robustly stabilize videos with various challenges.
Work-related Musculoskeletal Disorders among mail sorting officers in Sri Lanka: a cross sectional study

Background: Mail sorting requires repetitive movements of the upper limbs, target oriented tasks, long term standing or sitting, concentration and a good memory. The extent of musculoskeletal disorders (MSDs) among mail sorting officers (MSOs) is not known. This study was conducted to determine the prevalence and associated factors with work-related MSDs among MSOs in Sri Lanka. Methods : 250 randomly selected MSOs who were attached to the Central Mail Exchange, Colombo, were administered a pre-tested questionnaire after obtaining informed written consent. Information on demographic characteristics, musculoskeletal symptoms of the different body parts, job tasks, work history, job satisfaction, sick leave, feelings of job security, and personal perceptions of musculoskeletal symptoms during the past month were obtained. Data were analyzed using SPSS (version 16). Descriptive analyses were used to describe variables and chi-square tests were used to determine associations between pain symptoms and associated variables. Results: The prevalence of backache was highest (38.4%), followed by shoulder pain (27.6%), knee pain (21.2%), neck pain (16.4%), wrist and arm pain (11.2%) and elbow pain (10%). 59.6% of MSOs had experienced at least one MSDs sometime during the past 12 months. Mail sorting activities involved repetitive hand and wrist movements for more than four hours a day (n=239), repetitive bending and straightening of elbow more than one hour a day (n=239), keeping the hand above shoulder height for more than one hour a day (n=239) and climbing up and down more than 30 steps (n=218) a day. Height was significantly associated with shoulder pain (OR=1.056, 95% CI=1.069-3.577). Pain in all of the other sites was not associated with known risk factors in other studies. Conclusion: The predominant ergonomic problem in mail sorters in Sri Lanka are in the lower back, shoulder and neck areas. Although there is a high prevalence of some musculoskeletal symptoms in MSOs, most of the known risk factors identified in other studies such as age, right or left handedness, years of experience in current job, smoking habit and job satisfaction etc., were not significantly associated with MSDs in this population. Other physical, psychosocial and environmental factors need to be investigated. DOI: http://dx.doi. org/10.4038/jccpsl.v17i1. 4933 Journal of the College of Community Physicians of Sri Lanka Vol.17(2) June 2012 43-50
Direct Oral Anticoagulants and Their Use in Treatment and Secondary Prevention of Acute Symptomatic Venous Thromboembolism

Direct oral anticoagulants (DOACs) have been compared with standard therapy in large phase III studies to assess their safety and efficacy in the treatment of deep vein thrombosis and/or pulmonary embolism and in the secondary prevention of recurrent venous thromboembolism. Although the mean population age and the gross inclusion and exclusion criteria were similar across these studies, they differed in other aspects such as overall study design and acute treatment strategies. The 4 DOACs examined in phase III trials (apixaban, edoxaban, rivaroxaban, and dabigatran) showed noninferiority compared with standard therapy for the treatment of deep vein thrombosis and/or pulmonary embolism and for the prevention of recurrent venous thromboembolism. Furthermore, these DOACs exhibited a similar safety profile to standard therapy, with the risk of major bleeding significantly reduced in some of these studies. Rivaroxaban and apixaban were tested as a single-drug approach, whereas in the dabigatran and edoxaban studies, initial bridging with parenteral agents was employed. The purpose of this review is to compare the phase III studies of DOACs in this indication, to highlight the differences, and to discuss a series of clinically relevant issues, including the management of key patient subgroups (eg, fragile patients, those with cancer or renal impairment), extended treatment, use of comedications, heparin pretreatment versus a single-drug approach, and the bleeding profiles of the DOACs.