Miracle-dz/UniFAR-FTUs huggingface dataset:
Graphene-SGX: A Practical Library OS for Unmodified Applications on SGX

Intel SGX hardware enables applications to protect themselves from potentially-malicious OSes or hypervisors. In cloud computing and other systems, many users and applications could benefit from SGX. Unfortunately, current applications will not work out-of-the-box on SGX. Although previous work has shown that a library OS can execute unmodified applications on SGX, a belief has developed that a library OS will be ruinous for performance and TCB size, making application code modification an implicit prerequisite to adopting SGX. This paper demonstrates that these concerns are exaggerated, and that a fully-featured library OS can rapidly deploy unmodified applications on SGX with overheads comparable to applications modified to use "shim" layers. We present a port of Graphene to SGX, as well as a number of improvements to make the security benefits of SGX more usable, such as integrity support for dynamically-loaded libraries, and secure multiprocess support. Graphene-SGX supports a wide range of unmodified applications, including Apache, GCC, and the R interpreter. The performance overheads of Graphene-SGX range from matching a Linux process to less than 2× in most single-process cases; these overheads are largely attributable to current SGX hardware or missed opportunities to optimize Graphene internals, and are not necessarily fundamental to leaving the application unmodified. Graphene-SGX is open-source and has been used concurrently by other groups for SGX research.
Salivary and lacrimal gland dysfunction (sicca syndrome) after radioiodine therapy.

UNLABELLED Salivary gland dysfunction has been described in patients undergoing radioiodine therapy but associated lacrimal gland dysfunction (sicca syndrome) has never been reported. We conducted a prospective cohort study with follow-up for up to 3 y in a tertiary care university center to determine the prevalence of sicca syndrome in patients after high-dose radioiodine treatment. METHODS From January 1990 to December 1995, all patients undergoing radioiodine therapy (n = 79) with a standard dose of 925 MBq to 18.5 GBq (25-500 mCi) were interviewed using a standardized questionnaire to determine subjective ocular and oral dryness and were examined for objective lacrimal and salivary gland dysfunction. RESULTS After radioiodine treatment, 32.9% of the patients reported subjective xerostomia and 25.3% reported subjective xerophthalmia in the first year of follow-up. Xerostomia persisted to the second year of follow-up in 20.3% of cases and was still present >3 y after the last dose of radioiodine in 15.2% of cases. Xerophthalmia persisted to the second year of follow-up in 17.7% of cases and was still present in the third year of follow-up in 13.9% of cases. Severe xerostomia occurred in 4 patients. Reduced salivary and lacrimal gland function was documented in 40 (50.6%) and 14 (17.7%) of the 79 cases, respectively, in the first year of follow-up. Objective xerostomia persisted in 13.9% of cases to the second year of follow-up and was still present in all patients >3 y after the last radioiodine application. Keratoconjunctivitis sicca persisted in 11 patients (13.9%) to the second year of follow-up but was only present in 6 patients (7.6%) >3 y after the last radioiodine application. Additionally, 28/79 patients (35.4%) who had a normal salivary gland scintigraphy previously showed reduced salivary gland function in the third year of follow-up. No significant dependence on cumulative treatment was found for objective xerostomia or xerophthalmia, but doses >11.1 GBq (300 mCi) were related to stage 3 dysfunction on salivary gland scintigraphy. CONCLUSION Salivary and lacrimal gland dysfunction (sicca syndrome) is relatively frequent after radioiodine therapy. In most cases this is a transient side effect, but in some patients it may persist for a long period or appear late.
Evaluation of grading systems in stage I lung adenocarcinomas: a retrospective cohort study

Aims There is no internationally accepted grading system for lung adenocarcinoma despite the new WHO classification. The architectural grade, the Kadota grade and the Sica score were evaluated and compared with overall (OS) and disease-free survival (DFS). Methods Comprehensive histological subtyping was used in a series of resected stage I lung adenocarcinoma to identify subtypes of adenocarcinomas, the architectural grade, the Kadota grade, the Sica grade, the mitotic count, nuclear atypia, the presence of lymphovascular, vascular and airway propagation, necrosis, and micropapillary or solid growth pattern in any percentage. Statistical models fitted included Kaplan-Meier estimates and Cox proportional hazard regression models. Results 261 stage I adenocarcinomas were included. The 5-year survivals of different subtypes were as follows: lepidic (n=40, OS: 92.5%; DFS 91.6%), acinar (n=54, OS: 81.8%; DFS: 68.6%), papillary (n=49, OS: 73.6%; DFS: 61.0%), solid (n=95, OS: 64.7%; DFS: 57.8%) and micropapillary (n=23, OS: 34.8%; DFS: 33.5%). Concerning the architectural grade, there were significant differences between OS and DFS of low and intermediate (pOS=0.005, pDFS<0.001), low and high (pOS<0.001, pDFS<0.001) and intermediate and high grades (pOS=0.002, pDFS<0.001). Low-grade and intermediate grade tumours did not differ in survival according to Kadota grade and Sica grade. In the multivariable model, architectural grade was found to be an independent prognostic marker. In another model, architectural pattern proved to be superior to architectural grade. Conclusions Of the three grading systems compared, the architectural grade makes the best distinction between the outcome of low-grade, intermediate-grade and high-grade stage I adenocarcinomas.
Posttransplant Lymphoproliferative Disease in Children: Correlation of Histology to Clinical Behavior

Purpose To determine whether the morphologic features of posttransplant lymphoproliferative disease (PTLD) correlated to a response to therapy. Patients and Methods We reviewed our experience with PTLD in the pediatric population. We identified 32 patients with a total of 36 episodes of PTLD. The diagnosis was confirmed by tissue examination and classified according to the degree of monomorphic features of the lesion. Thirty-four of 36 episodes were managed with immunosuppression reduction, and the patients were assessed for their response to this strategy. Chemotherapy was used to treat 10 of 15 patients who had progressive disease, and their subsequent course was also analyzed. Results Sixteen of 17 (94%) patients with polymorphic morphology responded to immunosuppression reduction compared with only 5 of 17 (29%) patients with monomorphic features (P < 0.001). All of the patients with progressive disease who did not receive additional therapy died. Standard chemotherapy regimens for lymphoma were administered to 10 patients with progressive disease, with a high response rate (90%), durable remissions, and acceptable toxicity. Conclusions We conclude that the morphologic characteristics of PTLD provide information to potentially help guide treatment strategies in the management of this disease. Standard chemotherapy regimens for malignant lymphoma appear to be a viable treatment option for patients with progressive disease, although further investigation is needed.
Outcome of Escherichia coli and/or Klebsiella Bloodstream Infection in Children With Central Venous Catheters

We conducted a retrospective cohort study of children with catheter-associated bloodstream infections (BSIs) due to Escherichia coli and/or Klebsiella. Risk factors for poor outcome (ie, death or recurrence of infection) were receipt of mechanical ventilation (adjusted odds ratio [aOR], 4.6 [95% confidence interval {CI}, 1.39-16.30]) and receipt of total parenteral nutrition (aOR, 3.5 [95% CI, 1.1-10.8]). A significant proportion of children with catheter-associated BSI were treated successfully without catheter removal.
Langerhans cells in the development of skin cancer: A qualitative and quantitative comparison of cell markers in normal, acanthotic and neoplastic ovine skin

Summary The distribution of Langerhans cells in normal, acanthotic and neoplastic ovine epithelium was examined using the enzyme marker Acetylcholinesterase (AchE) and monoclonal antibodies (MoAb) to CD1 (20.27) and MHC Class II (49.1 and 28.1) molecules. In normal skin, where Langerhans cells were regularly spaced within the basal layer, qualitative observations and direct pairwise testing showed that AChE was superior to the MoAb in detecting these cells. Significantly more (P < 0.01) dendritic cells were also detected with MoAb 49.1 than MoAb 20.27 or 28.1, suggesting differential expression of MHC Class II subsets and the presence of CD1− MHC Class II+ granule− dendritic cells in sheep analogous to indeterminate cells of man. In acanthotic skin, compared to normal skin, Langerhans cells were less numerous, irregular and more suprabasal in distribution and their morphology was occasionally swollen and indistinct. No difference was seen in the ability of AChE and MoAb in detecting Langerhans cells, however pairwise testing of markers did demonstrate that significantly more (P<0.05) cells without dendritic processes were stained with MoAb 49.1 than with 20.27 or 28.1. In all squamous cell carcinomas examined dendritic cells that stained for AChE, CD1 or MHC Class II antigens were concentrated at the peripheral areas of neoplastic epithelium. Many dendritic cells were detected with MoAb to MHC Class II antigens, whereas CD1 and AChE positive dendritic cells were rare in tumor bearing tissue. The quantitative differences in the immunohistochemical staining of Langerhans cells between normal, acanthotic and neoplastic epithelium were consistent with ultrastructural studies. When compared with those of a newborn lamb, which had had very little exposure to antigens or ultraviolet radiation (UVR), the Langerhans cells of the aged sheep were deformed and contained far fewer Birbeck granules. The abnormalities were progressively more severe in acanthotic and neoplastic skin. These observed changes may have resulted from UVR induced damage and may be indicative of impaired function involved in the development of skin cancer.
Understanding physicians’ skills at providing end-of-life care

BACKGROUND: A framework for understanding and evaluating physicians’ skills at providing end-of-life care from the perspectives of patients, families, and health care workers will promote better quality of care at the end of life.OBJECTIVE: To develop a comprehensive understanding of the factors contributing to the quality of physicians’ care for dying patients.DESIGN: Qualitative study using focus groups and content analysis based on grounded theory.SETTING: Seattle, Washington.PARTICIPANTS: Eleven focus groups of patients with chronic obstructive pulmonary disease, AIDS, or cancer (79 patients); 3 groups of family members who had a loved one die of chronic disease (20 family members); 4 groups of nurses and social workers from hospice or acute care settings (27 health care workers); and 2 groups of physicians with expertise in end-of-life care (11 physicians). RESULTS: We identified 12 domains of physicians’ skills at providing end-of-life care: accessibility and continuity; team coordination and communication; communication with patients; patient education; inclusion and recognition of the family; competence; pain and symptom management; emotional support; personalization; attention to patient values; respect and humility; and support of patient decision making. Within these domains, we identified 55 specific components of physicians’ skills. Domains identified most frequently by patients and families were emotional support and communication with patients. Patients from the 3 disease groups, families, and health care workers identified all 12 domains. Investigators used transcript analyses to construct a conceptual model of physicians’ skills at providing end-of-life care that grouped domains into 5 categories.CONCLUSIONS: The 12 domains encompass the major aspects of physicians’ skills at providing high-quality end-of-life care from the perspectives of patients, their families, and health care workers, and provide a new framework for understanding, evaluating, and teaching these skills. Our findings should focus physicians, physician-educators, and researchers on communication, emotional support, and accessibility to improve the quality of end-of-life care.
Use of Natural Latex as a Biomaterial for the Treatment of Diabetic Foot — A New Approach to Treating Symptoms of Diabetes Mellitus

In this chapter, we present the results of a study on factors that contribute to the prevention and treatment of diabetic foot ulcers using natural latex biomaterials made from Hevea brasiliensis, in the form of biomaterials applied to humans (in this case, in direct contact with the human skin). The chapter is organized in the following way: in section 2, it is defined what a diabetic foot is, to provide the context for addressing the problem. The use of natural latex biomaterials made from Hevea brasiliensis is discussed in the context of biotechnology, wherein Hevea brasiliensis is used as a raw material in the prevention and treatment of diabetic foot. In section 3, the diabetic foot is described by a mathematical model and it is presented how the use of biomaterial latex acts as modifier of the dynamics of the system to believe this application as a minor theory and/or auxiliary hypothesis in the biotechnological process as it applies to humans. In section 4 and 5 the chapter closes with a presentation of a "natural latex insole" prototype capable of preventing and treating diabetic foot ulcers.
Independence of visual awareness from attention at early processing stages

According to a widely accepted idea, only the results of attentional selection reach visual awareness. A competing model postulates that awareness is independent of attentional selection: contents of subjective visual experience may also exist without the contribution of attention. We tested these competing models by tracking the independent contributions of selective attention and awareness to electrophysiological brain responses. Our results showed that the earliest effects of visual awareness emerged earlier than the effects of attention and regardless of the presence or absence of attention. The early effects of attention were elicited regardless of the presence or absence of awareness. The results suggest that visual awareness and selective attention are initially independent of each other.
Biphalangia of the lateral toes. A study on the incidence in a Swedish population together with some observations on digital sesamoid bones in the foot.

The incidence of a two-phalangeal fifth toe in a Swedish population has been investigated in a series of 496 persons. The incidence is about 35% without significant differences between sexes or between age groups. The figure coincides with that found in studies on German, English and Danish populations but differs from that of American and that of Japanese populations. It is concluded that the cause of this anomaly is genetic and that the two-phalangeal fifth toe may be an important parameter in racial studies and for the identification of an individual. Each phalanx in the two-phalangeal toe is on the average almost 5 mm longer than its counterpart in the three-phalangeal variety, resulting in the paradoxic fact that the three-phalangeal toe is shorter on the average than the two-phalangeal one. The numbers of sesamoid bones in various locations of the toes are presented.
Samarium-153 treatment of bone pain in patients with metastatic prostate cancer.

INTRODUCTION Painful bone metastases are common in advanced prostate cancer. We report the clinical outcome after administration of Samarium-153 ((153)Sm), an emitter of beta-particles that concentrates in the areas of enhanced osteoblastic activity. METHODS Twenty-two patients (median age 73 years) with metastatic, hormone-refractory prostate cancer received a single bolus infusion of (153)Sm (37 MBq/kg). All patients had painful bone metastases to more than one anatomical region, and most had inadequate pain relief to narcotic analgesics. Bone specific pain, analgesic score according to WHO, ECOG performance status, and blood count were evaluated before and up to 28 weeks after treatment. RESULTS Median follow-up was six weeks (mean 14 weeks). Eleven patients died within the 28 week observation period (ten from terminal disease), and four patients had their observation period truncated. Median pain score was 56.3%, 50.0%, and 50.0% of baseline values at week 4 (n = 20), 16 (n = 10), and 28 (n = 7), respectively. A reduction of baseline pain score by 50% or more was observed in 50%, 70% and 71% of patients at week 4, 16, and 28, respectively. Hematological toxicity was mild and reversible in most cases. CONCLUSION Administration of (153)Sm to prostate cancer patients with painful bone metastases offered clinical relevant pain relief with tolerable hematological toxicity.
Transparency in Buyer‐Determined Auctions: Should Quality be Private or Public?

We study buyer‐determined procurement auctions where both price and non‐price characteristics of bidders matter for being awarded a contract. Although, in scoring auctions bidders perfectly know how price and non‐price attributes determine the awarding of the contract, this remains uncertain in buyer‐determined auctions where the buyer is free to choose once all bids have been submitted. We analyze the impact of information bidders have with respect to the buyer's awarding decision. As we show theoretically whether it is in the buyer's interest to conceal the impact of non‐price characteristics depends on how important the quality aspects of the procured good are to the buyer: The more important quality aspects are, the more interesting concealment becomes. In a counterfactual analysis using data from a large European procurement platform, we analyze the reduction of non‐price information available to the bidders. Confirming our hypothesis, for auction categories where bidders’ non‐price characteristics strongly influence buyers’ decisions concealment of non‐price information leads to an increase in buyers’ surplus of up to 15% due to higher competitive pressure and lower bids. Conversely, for categories where bidders’ non‐price characteristics are of little importance concealment of non‐price information leads to a decrease in buyers’ surplus of up to 6%.
Multiple Facial Image Editing Using Edge–Aware PDE Learning

This paper introduces a novel facial editing tool, called edge‐aware mask, to achieve multiple photo‐realistic rendering effects in a unified framework. The edge‐aware masks facilitate three basic operations for adaptive facial editing, including region selection, edit setting and region blending. Inspired by the state‐of‐the‐art edit propagation and partial differential equation (PDE) learning method, we propose an adaptive PDE model with facial priors for masks generation through edge‐aware diffusion. The edge‐aware masks can automatically fit the complex region boundary with great accuracy and produce smooth transition between different regions, which significantly improves the visual consistence of face editing and reduce the human intervention. Then, a unified and flexible facial editing framework is constructed, which consists of layer decomposition, edge‐aware masks generation, and layer/mask composition. The combinations of multiple facial layers and edge‐aware masks can achieve various facial effects simultaneously, including face enhancement, relighting, makeup and face blending etc. Qualitative and quantitative evaluations were performed using different datasets for different facial editing tasks. Experiments demonstrate the effectiveness and flexibility of our methods, and the comparisons with the previous methods indicate that improved results are obtained using the combination of multiple edge‐aware masks.
Ensuring bidirectional cavotricuspid isthmus conduction block during ablation for typical atrial flutter—A new twist on an old problem

This editorial will review the new pacing method described by the authors in this issue of the journal that they propose to ensure bi-directional cavo-tricuspid isthmus (CTI) conduction block after radiofrequency catheter ablation in patients with CTI dependent atrial flutter. This article is protected by copyright. All rights reserved.
Adaptive rejection of disturbances having two sinusoidal components with close and unknown frequencies

The paper considers the problem of rejecting disturbances composed of two sinusoidal signals with frequencies that are close to each other. A natural approach consists in treating the two components separately. However, when the frequencies are close and unknown, the convergence of a double frequency estimator is typically slow, due to the difficulty in distinguishing the components. The alternative approach taken in this paper consists in representing the disturbance signal as a single sinusoid with time-varying magnitude and phase. The theoretical basis and the limitations of such a representation are first discussed. Then, an adaptive disturbance rejection algorithm is proposed and the resulting nonlinear system is analyzed using various approximations. Simulation results show that the proposed algorithm has better convergence properties than an algorithm designed to cancel the two frequency components separately. In some cases, however, the cost is a small residual error.
Eating disorders in patients with obsessive-compulsive disorder: prevalence and clinical correlates.

OBJECTIVE The objective is to evaluate the prevalence and associated clinical characteristics of eating disorders (ED) in patients with obsessive-compulsive disorder (OCD). METHOD This is a cross-sectional study comparing 815 patients with OCD. Participants were assessed with structured interviews and scales: SCID-I, Y-BOCS, Dimensional Y-BOCS, BABS, Beck Depression and Anxiety Inventories. RESULTS Ninety-two patients (11.3%) presented the following EDs: binge-eating disorders [= 59 (7.2%)], bulimia nervosa [= 16 (2.0%)], or anorexia nervosa [= 17 (2.1%)]. Compared to OCD patients without ED (OCD-Non-ED), OCD-ED patients were more likely to be women with previous psychiatric treatment. Mean total scores in Y-BOCS, Dimensional Y-BOCS, and BABS were similar within groups. However, OCD-ED patients showed higher lifetime prevalence of comorbid conditions, higher anxiety and depression scores, and higher frequency of suicide attempts than did the OCD-Non-ED group. Primarily diagnosed OCD patients with comorbid ED may be associated with higher clinical severity. DISCUSSION Future longitudinal studies should investigate dimensional correlations between OCD and ED.
Effect of calcitonin on the rates of bone formation and resorption in the rat.

The rates of matrix and bone formation and bone resorption were measured histologically in the tibial diaphysis of thyroparathyroidectomized rats. Compared to control animals, the rates of matrix and bone formation and bone resorption both were decreased significantly in rats given 3 Hirsch units of calcitonin every 8 hr for 6 days. The magnitude of the decrease of resorption was 68%, that of bone formation was 24%, and that of matrix formation was 22%. (Endocrinology 84: 261, 1969)