Miracle-dz/UniFAR-FTUs huggingface dataset:
Competitive Enzymatic Interactions Determine the Relative Amounts of Prostaglandins E2 and D2

Prostaglandins (PGs) are a family of cellular messengers exerting diverse homeostatic and pathophysiologic effects. Recently, several studies reported significant increases of PGI2 and PGF2α after the inhibition of microsomal PGE synthase-1 (mPGES-1) expression, which indicated that PGH2 metabolism might be redistributed when the PGE2 pathway is blocked. To address the determinants that govern the relative amounts of PGs, we developed an in vitro cell-free method, based on liquid chromatography-tandem mass spectrometry, to measure the exact amounts of these PGs formed in response to the addition of recombinant isomerases and their selective inhibitors. Our in vitro cell-free assay results were confirmed in cells using bone marrow-derived macrophage. Initially, we determined the in vitro stability of PGH2 and noted that there was spontaneous nonenzymatic conversion to PGD2 and PGE2. mPGES-1 markedly increased the conversion to PGE2 and decreased conversion to PGD2. Reciprocally, the addition of hematopoietic or lipocalin PGD synthase resulted in a relative increase of PGD2 and decrease of PGE2. A detailed titration study showed that the ratio of PGE2/PGD2 was closely correlated with the ratio of PGE synthase/PGD synthase. Our redistribution results also provide the foundation for understanding how PGH2 metabolism is redistributed by the presence of distal isomerases or by blocking the major metabolic outlet, which could determine the relative benefits and risks resulting from interdiction in nonrated-limiting components of PG synthesis pathways.
Rising Capital Shares, Risk Taking and The Secular Stagnation

In the last 20 years we have witnessed a decline in the labor shares, low real interest rates and anemic growth in developed economies. Using a neoclassical growth model with Cobb Douglas technology, a capital intensity that fluctuates over time, and a financial frictions, we explore whether changes in the relative productivity of capital can generate these facts through changes in the risk taking behavior of capital holders and what would be the implications for financial regulations. A combination of financial frictions and a persistent change in the capital intensity (decline in the labor share) can account for a decline in the price of risk, and a moderate increase in the dividends of capital firms but cannot account for the decrease in the real rates.
Vaccination with a Recombinant Saccharomyces cerevisiae Expressing a Tumor Antigen Breaks Immune Tolerance and Elicits Therapeutic Antitumor Responses

Purpose:Saccharomyces cerevisiae, a nonpathogenic yeast, has been used previously as a vehicle to elicit immune responses to foreign antigens, and tumor-associated antigens, and has been shown to reduce tumor burden in mice. Studies were designed to determine if vaccination of human carcinoembryonic antigen (CEA)-transgenic (CEA-Tg) mice (where CEA is a self-antigen) with a recombinant S. cerevisiae construct expressing human CEA (yeast-CEA) elicits CEA-specific T-cell responses and antitumor activity. Experimental Design: CEA-Tg mice were vaccinated with yeast-CEA, and CD4+ and CD8+ T-cell responses were assessed after one and multiple administrations or vaccinations at multiple sites per administration. Antitumor activity was determined by tumor growth and overall survival in both pulmonary metastasis and s.c. pancreatic tumor models. Results: These studies demonstrate that recombinant yeast can break tolerance and that (a) yeast-CEA constructs elicit both CEA-specific CD4+ and CD8+ T-cell responses; (b) repeated yeast-CEA administration causes increased antigen-specific T-cell responses after each vaccination; (c) vaccination with yeast-CEA at multiple sites induces a greater T-cell response than the same dose given at a single site; and (d) tumor-bearing mice vaccinated with yeast-CEA show a reduction in tumor burden and increased overall survival compared to mock-treated or control yeast-vaccinated mice in both pulmonary metastasis and s.c. pancreatic tumor models. Conclusions: Vaccination with a heat-killed recombinant yeast expressing the tumor-associated antigen CEA induces CEA-specific immune responses, reduces tumor burden, and extends overall survival in CEA-Tg mice. These studies thus form the rationale for the incorporation of recombinant yeast-CEA and other recombinant yeast constructs in cancer immunotherapy protocols.
SYSTEMIC SAFETY OF RANIBIZUMAB FOR DIABETIC MACULAR EDEMA: Meta-analysis of Randomized Trials

Purpose: To evaluate systemic safety of ranibizumab for diabetic macular edema. Methods: MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov were systematically reviewed. Eligible studies were randomized trials on ranibizumab for diabetic macular edema with observation at least 6 months and ≥80% completion rate that reported systemic adverse events of cerebrovascular accident, myocardial infarction, vascular death, and overall mortality. The numbers of adverse events were compared between patients treated with ranibizumab and those without. Furthermore, dose-dependent effect of ranibizumab was estimated for overall mortality through Poisson meta-regression. Results: Six trials with 2,459 patients were included. All trials had exclusion criteria on systemic vascular conditions for enrollment. Risk ratio for cerebrovascular accident, myocardial infarction, vascular death, and overall mortality were 0.80 (95% confidence interval, 0.37–1.73; P = 0.57), 0.91 (95% confidence interval, 0.46–1.80; P = 0.78), 1.29 (95% confidence interval, 0.58–2.86; P = 0.53), and 1.92 (95% confidence interval, 0.78–4.73; P = 0.16), respectively. Poisson regression model showed a significant dose-dependent increase in overall mortality in the largest randomized trial using monthly ranibizumab (P = 0.04). However, the significance disappeared (P = 0.133) when pooled with other studies using ranibizumab on pro re nata basis. Conclusion: Ranibizumab for diabetic macular edema is considered safe when the patients are carefully selected based on systemic vascular conditions and it is used on pro re nata basis. Further evaluation is necessary on more intensive use or on high-risk patients.
Estrogen Treatment Down-Regulates TNF-α Production and Reduces the Severity of Experimental Autoimmune Encephalomyelitis in Cytokine Knockout Mice1

A shift toward Th2 cytokine production has been demonstrated during pregnancy and high dose estrogen therapy and is thought to be the primary mechanism by which estrogen suppresses the development of experimental autoimmune encephalomyelitis. However, low dose estrogen treatment is equally protective in the absence of a significant shift in cytokine production. In this study cytokine-deficient mice were treated with estrogen to determine whether a shift in Th2 cytokine production was required for the protective effects of hormone therapy. Estrogen effectively suppressed the development of experimental autoimmune encephalomyelitis in IL-4 and IL-10 knockout mice and in wild type littermate mice with a similar potency of protection. Significant disease suppression was also seen in IFN-γ-deficient mice. The decrease in disease severity was accompanied by a concomitant reduction in the number of proinflammatory cytokine- and chemokine-producing cells in the CNS. Although there was no apparent increase in compensatory Th2 cytokine production in cytokine-deficient mice, there was a profound decrease in the frequency of TNF-α-producing cells in the CNS and the periphery. Therefore, we propose that one mechanism by which estrogen protects females from the development of cell-mediated autoimmunity is through a hormone-dependent regulation of TNF-α production.
Economic Consequences of Implementing and Communicating Value Based Management Systems

We study the consequences of implementing and communicating Value Based Management (VBM) systems on information asymmetries and the cost of capital. We analyse the firms’ reporting on internal control systems as the source of information for market participants. In addition, literature posits that improving communications with shareholders by providing additional information on value generation (Value Based Reporting, VBR) is an integral part of implementing VBM. We find that the implementation of VBM and the extent of VBR are, both individually and jointly, significantly related to lower information asymmetries and lower cost of capital. We find a slight moderation of the effect of VBM by VBR. For increasing VBR, we find that information asymmetries and cost of capital decrease more strongly for firms without implemented VBM systems. This indicates that VBR can to some extent substitute VBM. Overall, however, firms using a combination of VBM and VBR attain lower levels of information asymmetry and cost of capital. We provide evidence for the real effects of disclosure, suggesting that disclosures on internal control systems serve as a governance mechanism, reducing information asymmetries and the cost of capital by aligning shareholders’ and managers’ interests.
Culture and school leadership in China: Exploring school leaders' views of relationship- and rule-based governance

Numerous Chinese management studies have demonstrated significant differences between Chinese and Western management. This exploratory paper investigates the impact of Chinese culture and Western traditions on China's contemporary school leaders' views of leadership and management, particularly in the areas of relationship building, delegation, and promotion. Data were drawn from questionnaires completed by school leaders and individual interviews with principals from different parts of China. The findings indicate that the differences between Chinese and Western management practices in Chinese schools are not static and should not be over-stressed. To different extents, the respondent school leaders of China were affected by both Chinese and Western values and practices in school leadership and management. Specifically, they were more influenced by Chinese culture in the areas of school management and organization and by Western values and practices in the areas of relationship building, staff performance, and promotion. Their leadership and management preferences were also influenced by other factors, including gender, domestic politics, and development.
The effect of audit committee effectiveness and audit quality on corporate voluntary disclosure quality

Purpose The purpose of this paper is to examine the linkages between audit committees’ (AC) effectiveness, audit quality and corporate voluntary disclosure quality (VDQ). Design/methodology/approach Empirical tests address 144 firm-year observations drawn from Ghanaian listed companies during 2013–2016. Findings The results document a substitute and complementary effect between the presence of Big Four auditor and effective AC in increasing quality voluntary disclosure. Originality/value This study is one of the few that have examined the effect of AC effectiveness and audit quality on corporate VDQ. The findings lend credence to the belief that AC effectiveness and Big Four auditors complement each other to enhance quality of voluntary information disclosure.
A 0.6-V 38-nW 9.4-ENOB 20-kS/s SAR ADC in 0.18-$\mu{\rm m}$  CMOS for Medical Implant Devices

This paper presents a 10-bit ultra-low power successive approximation register (SAR) analog-to-digital converter (ADC) for implantable medical devices. To achieve the nanowatt range power consumption, a novel switching scheme is proposed, which can accomplish the first three comparisons without consuming any energy and thus improve the energy efficiency significantly. In addition, to boost the offset performance of the comparator working under low supply voltage, a detailed theoretical analysis of comparator offset voltages is made. Based on the analysis, the comparator is optimized by only adjusting transistor sizes without any particular offset cancellation. As a result, when the common-mode input voltage varies from 300 mV to 450 mV at a 0.6 V supply, the 3×σ offset voltage is optimized to be about 6 mV with a fluctuation of only 0.15 mV, as revealed by Monte Carlo simulations. A prototype of the proposed ADC was fabricated in 0.18 μm 1P6M CMOS technology, which occupies an active area of only 380×430 μm2. At a 0.6-V supply and 20 kS/s sampling rate, the ADC achieves an SNDR of 58.3 dB and a power consumption of 38 nW, resulting in a figure of merit (FOM) of 2.8 fJ/conversion-step.
High-risk occupations for breast cancer in the Swedish female working population.

OBJECTIVES The purpose of this study was to estimate, for the period 1971 through 1989, occupation-specific risks of breast cancer among Swedish women employed in 1970. METHODS Age-period standardized incidence ratios were computed. Log-linear Poisson models were fitted, with geographical area and town size taken into account. Risks were further adjusted for major occupational group, used as a proxy for socioeconomic status. Risk estimators were also calculated for women reporting the same occupation in 1960 and 1970. RESULTS Most elevated risks among professionals, managers, and clerks were reduced when intragroup comparisons were carried out, indicating the confounding effect of socioeconomic status. Excess risks were found for pharmacists, teachers of theoretical subjects, schoolmasters, systems analysts and programmers, telephone operators, telegraph and radio operators, metal platers and coaters, and hairdressers and beauticians, as well as for women working in 1960 and 1970 as physicians, religious workers, social workers, bank tellers, cost accountants, and telephonists. CONCLUSIONS While the high risks observed among professional, administrative, and clerical workers might be related to lower birth rates and increased case detection, excess risks found for telephone workers and for hairdressers and beauticians deserve further attention.
The Application of CT to Localize the Upper Airway Obstruction Plane in Patients with OSAHS

Objective To identify a correlation in terms of airway obstruction between awake and sleep apnea using spiral computed tomography (CT). Study Design Case series with planned data collection. Setting College medical center. Methods Sixty-one patients diagnosed with obstructive sleep apnea/hypopnea syndrome (OSAHS) underwent CT scans under 3 conditions: quiet breathing while awake, the end of deep inspiration during wakefulness, and apnea while asleep. The upper airway morphology under the 3 conditions was compared, and the accuracy of the obstructive planes as determined by CT scans under the 2 awake conditions was analyzed while considering the obstructive planes that occurred during apnea as a reference. Results The differences in the anteroposterior diameter, lateral dimension, and cross-sectional area of the retropalatal and retroglossal regions among the 3 states were statistically significant. Obstruction of the retropalatal region occurred in 100%, whereas retroglossal obstruction occurred in 44.3% of the 61 cases during sleep apnea. The coincidence rate between the awake quiet breathing and the sleep apnea was 85.2% in the retropalatal obstruction and 52.5% in the retroglossal obstruction. The coincidence rate between the awake deep inspiration and the sleep apnea was 82.0% in the retropalatal obstruction and 54.1% in the retroglossal obstruction. Conclusion The main obstructive plane in patients with OSAHS was the retropalatal region. An awake upper airway CT scan can properly diagnose palatopharyngeal obstruction; however, it is not suitable for detecting retroglossal obstruction.
The Benefits of Teleworking in the Public Sector: Reality or Rhetoric?

Many public organizations implement teleworking: an organizational innovation expected to improve the working conditions of public servants. However, it is unclear to what extent teleworking is beneficial for public servants. This study adds to the literature by studying the effects of teleworking on a day-to-day basis. We used a daily diary methodology and followed public servants across five consecutive working days. Studies that apply a daily survey method are more accurate than cross-sectional measures because they reduce recall bias. The results highlight that public servants experience quite negative effects from teleworking, including greater professional isolation and less organizational commitment on the days that they worked entirely from home. Contrary to predictions, working from home did not affect work engagement. We also found that higher leader–member exchange (LMX) reduced the impact of teleworking on professional isolation. These findings not only contribute to the literature by showing the unfavorable effects of teleworking but also highlight that LMX can, to some extent, reduce these negative effects.
Organization and Use of the Mental Lexicon by Deaf and Hearing Individuals

Two experiments explored the taxonomic organization of mental lexicons in deaf and hearing college students. Experiment 1 used a single-word association task to examine relations between categories and their members. Results indicated that both groups' lexical knowledge is similar in terms of overall organization, with associations between category names and exemplars stronger for hearing students; only the deaf students showed asymmetrical exemplar-category relations. Experiment 2 used verbal analogies to explore the application of taxonomic knowledge in an academically relevant task. Significant differences between deaf and hearing students were obtained for six types of analogies, although deaf students who were better readers displayed response patterns more like hearing students'. Hearing students' responses reflected their lexical organization; deaf students' did not. These findings implicate the interaction of word knowledge, world knowledge, and literacy skills, emphasizing the need to adapt instructional methods to student knowledge in educational contexts.
Polytherapy, Monotherapy, and Carbamazepine

Summary: Despite the widespread and traditional use of polytherapy in the treatment of epilepsy, there is little evidence of its advantages over monotherapy. Among other undesirable effects, it can produce subtle cognitive and behavioral changes and sometimes even exacerbate the epilepsy. Recent studies provide evidence that in many patients seizures can be controlled by carefully monitored monotherapy: Approximately 75% of newly diagnosed, previously untreated epileptic patients will enter a 2‐year remission with this form of treatment. The theory has even been advanced that early control of seizures may help prevent the evolution of drug‐resistant, chronic epilepsy. In some patients with chronic epilepsy, multiple‐drug therapy can be reduced to single‐drug treatment, usually with an improvement in cognitive function and without increase in seizures. Trials conducted to date have shown no evidence of superiority of any one major antiepileptic drug over another in control of a particular seizure type. The choice of antiepileptic drug for monotherapy may therefore be influenced by differences in toxic effects associated with individual agents. On the basis of clinical and psychometric evidence, carbamazepine has been shown to cause fewer adverse effects than other antiepileptic drugs on cognitive function, mood, and behavior.
Early Childhood Education by Television: Lessons from Sesame Street

We investigate whether preschool-age children exposed to Sesame Street when it aired in 1969 experienced improved educational and labor market outcomes. We exploit geographic variation in broadcast reception derived from technological factors, namely UHF versus VHF transmission. This variation is then related to census data on grade-for-age status, educational attainment, and labor market outcomes. The results indicate that Sesame Street improved school performance, particularly for boys. The point estimates for long-term educational and labor market outcomes are generally imprecise. (JEL I21, I26, J13, J24, L82)
Syndecan-4 core protein is sufficient for the assembly of focal adhesions and actin stress fibers.

The formation of focal adhesions and actin stress fibers on fibronectin is dependent on signaling through (&bgr;)1 integrins and the heparan sulfate proteoglycan syndecan-4, and we have analyzed the requirement of the glycosaminoglycan chains of syndecan-4 during these events. Chinese hamster ovary cells with mutations in key enzymes of the glycanation process do not synthesize glycosaminoglycan chains and are unable to assemble actin stress fibers and focal contacts when cultured on fibronectin. Transfection of the mutant cells with a cDNA that encodes the core protein of chicken syndecan-4 leads to the production of unglycanated core protein. The overexpression of syndecan-4 core protein in these mutant cells increases cell spreading and is sufficient for these cells to assemble actin stress fibers and focal adhesions similar to wild-type cells seeded on fibronectin and vitronectin matrices. Syndecan-4 core protein colocalizes to focal contacts in mutant cells that have been transfected with the syndecan-4 core protein cDNA. These data indicate an essential role for the core protein of syndecan-4 in the generation of signals leading to actin stress fiber and focal contact assembly.
Political Stability in Absence of Violence and Economic Growth in Pakistan

This snapshot of political stability in absence of violence (POLIT) and economic growth (ECG) is analyzed in this study for period 1980-2016. The Ng-Perron is used to determine to order of integration. The findings shows that both series are integrated of order one. The short run impact of political stability in absence of violence on economic growth in Pakistan is determined by using VAR test and long term relationship is determined with help of Johansen Cointegration technique. This test point out that both series are integrated of order one. The impulse response functions show that there is a positive and significant short-run association between economic growth and political stability in absence of violence. Further, analysis Granger causality test showed that there was a unidirectional causality from POLIT to ECG. Policies that will assist in the control of violence and other regulatory measures are recommended to boost up economic growth in Pakistan.
Cumulative Impact of Host and Viral Factors on HIV-1 Viral-Load Control during Early Infection

ABSTRACT In HIV-1 infection, the early set-point viral load strongly predicts both viral transmission and disease progression. The factors responsible for the wide spectrum of set-point viral loads are complex and likely reflect an interplay between the transmitted virus and genetically defined factors in both the transmitting source partner and the seroconverter. Indeed, analysis of 195 transmission pairs from Lusaka, Zambia, revealed that the viral loads in transmitting source partners contributed only ∼2% of the variance in early set-point viral loads of seroconverters (P = 0.046 by univariable analysis). In multivariable models, early set-point viral loads in seroconverting partners were a complex function of (i) the viral load in the source partner, (ii) the gender of the seroconverter, (iii) specific HLA class I alleles in the newly infected partner, and (iv) sharing of HLA-I alleles between partners in a transmission pair. Each of these factors significantly and independently contributed to the set-point viral load in the newly infected partner, accounting for up to 37% of the variance observed and suggesting that many factors operate in concert to define the early virological phenotype in HIV-1 infection.