Miracle-dz/UniFAR-FTUs huggingface dataset:
Board financial expertise and dividend-paying behavior of firms

Purpose Numerous researchers have developed theories and studies to uncover the issues pertinent to dividend policy dynamics, but it is still one of the unresolved problems of finance. The purpose of this paper is to focus on a new dimension, i.e., financial expertise on the corporate board for explaining the dividend policy dynamics in the emerging equity markets of China and Pakistan. Design/methodology/approach The study employs static (fixed effect (FE) and random effect (RE)) and dynamic models – two-step generalized method of moments (GMM) estimation techniques by Arellano and Bond (1991) and Arellano and Bover (1995) – during the timespan from 2009 to 2014. Further, this study re-estimated FE, RE and GMM two-step estimation techniques by excluding the non-dividend-paying companies, and also employed instrumental variable regressing by using two instrumental variables – industry average financial expertise of the board and board size – as proxies for board financial expertise to control the possible endogeneity. Findings The study reveals that Chinese firms having more financial expertise on the board do not take dividends as a control mechanism (substitution hypothesis), while Pakistani firms support the compliment hypothesis and use dividends as a control mechanism to mitigate agency conflict to protect shareholders’ interests and keep additional funds from the manager’s opportunism. Further robustness models also confirm the presence of a significant association between dividend policy and board financial expertise in both equity markets. Originality/value This study introduces the financial expertise on a board as a determinant of dividend policy. To the best of the authors’ knowledge, no previous studies have focused on board-level financial expertise as a contributing factor toward dividend policy.
Specific characteristic of radial glia in the human fetal telencephalon

Phenotypic characteristics of cells in the developing human telencephalic wall were analyzed using electron microscopy and immunocytochemistry with various glial and neuronal cell markers. The results suggest that multiple defined cell types emerge in the neocortical proliferative zones and are differentially regulated during embryonic development. At 5–6 weeks gestation, three major cell types are observed. Most proliferating ventricular zone (VZ) cells are labeled with radial glial (RG) markers such as vimentin, glial fibrillary acidic protein (GFAP), and glutamate astrocyte‐specific transporter (GLAST) antibodies. A subpopulation of these RG cells also express the neuronal markers β III‐tubulin, MAP‐2, and phosphorylated neurofilament SMI‐31, in addition to the stem cell marker nestin, indicating their multipotential capacity. In addition, the presence of VZ cells that immunoreact only with neuronal markers indicates the emergence of restricted neuronal progenitors. The number of multipotential progenitors in the VZ gradually decreases, whereas the number of more restricted progenitors increases systematically during the 3‐month course of human corticogenesis. These results suggest that multipotential progenitors coexist with restricted neuronal progenitors and RG cells during initial corticogenesis in the human telencephalon. Since the multipotential VZ cells disappear during the major wave of neocortical neurogenesis, the RG and restricted neuronal progenitors appear to serve as the main sources of cortical neurons. Thus, the diversification of cells in human VZ and overlying subventricular zone (SVZ) begins earlier and is more pronounced than in rodents. © 2004 Wiley‐Liss, Inc.
Case Report: Reconstruction of a Large Maxillary Defect With an Engineered, Vascularized, Prefabricated Bone Graft

The reconstruction of complex midface defects is a challenging clinical scenario considering the high anatomical, functional, and aesthetic requirements. In this study, we proposed a surgical treatment to achieve improved oral rehabilitation and anatomical and functional reconstruction of a complex defect of the maxilla with a vascularized, engineered composite graft. The patient was a 39-year-old female, postoperative after left hemimaxillectomy for ameloblastic carcinoma in 2010 and tumor-free at the 5-year oncological follow-up. The left hemimaxillary defect was restored in a two-step approach. First, a composite graft was ectopically engineered using autologous stromal vascular fraction (SVF) cells seeded on an allogenic devitalized bone matrix. The resulting construct was further loaded with bone morphogenic protein-2 (BMP-2), wrapped within the latissimus dorsi muscle, and pedicled with an arteriovenous (AV) bundle. Subsequently, the prefabricated graft was orthotopically transferred into the defect site and revascularized through microvascular surgical techniques. The prefabricated graft contained vascularized bone tissue embedded within muscular tissue. Despite unexpected resorption, its orthotopic transfer enabled restoration of the orbital floor, separation of the oral and nasal cavities, and midface symmetry and allowed the patient to return to normal diet as well as to restore normal speech and swallowing function. These results remained stable for the entire follow-up period of 2 years. This clinical case demonstrates the safety and the feasibility of composite graft engineering for the treatment of complex maxillary defects. As compared to the current gold standard of autologous tissue transfer, this patient’s benefits included decreased donor site morbidity and improved oral rehabilitation. Bone resorption of the construct at the ectopic prefabrication site still needs to be further addressed to preserve the designed graft size and shape.
An 80-Kilodalton Protein That Binds to the Pre-S1 Domain of Hepatitis B Virus

ABSTRACT It has been suggested that hepatitis B virus (HBV) binds to a receptor on the plasma membrane of human hepatocytes via the pre-S1 domain of the large envelope protein as an initial step in HBV infection. However, the nature of the receptor remains controversial. In an attempt to identify a cell surface receptor for HBV, purified recombinant fusion protein of the pre-S1 domain of HBV with glutathioneS-transferase (GST), expressed in Escherichia coli, was used as a ligand. The surface of human hepatocytes or HepG2 cells was biotinylated, and the cell lysate (precleared lysate) which did not bind to GST and glutathione-Sepharose beads was used as a source of receptor molecules. The precleared lysate of the biotinylated cells was incubated with the GST–pre-S1 fusion protein, and the bound proteins were visualized by Western blotting and enhanced chemiluminescence. An approximately 80-kDa protein (p80) was shown to bind specifically to the pre-S1 domain of the fusion protein. The receptor binding assay using serially or internally deleted segments of pre-S1 showed that amino acid residues 12 to 20 and 82 to 90 are essential for the binding of pre-S1 to p80. p80 also bound specifically to the pre-S1 of native HBV particles. Analysis of the tissue and species specificity of p80 expression in several available human primary cultures and cell lines of different tissue origin showed that p80 expression is not restricted to human hepatocytes. Taken together the results suggest that p80 may be a component of the viral entry machinery.
The Politics of Structural Reform: Why Agencies Are Transformed and Put to Death

The Norwegian bureaucracy is subjected to structural changes on a regular basis. The frequency at which this occurs begs the question: Why does it happen? In the literature, termination (organizational death) has been devoted more attention than other organizational changes. However, such studies have thus far only been carried out in majoritarian systems, and are not immediately transferable to consensus democracies like Norway. This thesis represents an exploratory attempt at adapting theories of termination to a Norwegian context. By running a series of discrete survival regressions on 142 Norwegian agencies between 1980 and 2014 (based on a unique and constructed dataset), I find that agencies are at much higher risk of being terminated after a change in government. While this finding suggests that political executives have considerable influence over government structure, another finding indicates that there are limits to their power. For example, large, geographically dispersed and young agencies seem to at lower risk of being terminated. I find no evidence that fiscal pressure or the attributes of the government matters. Since termination is a disputed concept, I also empirically examine whether terminations are conceptually different from reorganizations. I develop an alternative hypothesis, which argues that they can be merged and referred to collectively as “structural reforms. ” By running the same regressions with reorganizations as a dependent variable, I find that there should be a clear distinction between terminations and reorganizations. First, very few effects are found. Second, large and geographically dispersed agencies are at higher risk of being reorganized, an empirical pattern that is contrary to what termination theory expects. Thus, the viability of structural reform as a fruitful theoretical concept is debunked.
Location and Coverage Analysis of Bike- Sharing Stations in University Campus

Abstract Background: Bike-sharing programmes have become popular in a large number of cities in order to facilitate bicycle use. Determining the location of bike sharing stations is vital to success of these programmes. Objectives: In this paper, a case study is applied to the Gaziantep University campus in order to find possible locations of the stations for users (students). The purpose is to minimize the total walking distance. Methods/Approach: Set and maximal covering mathematical models are considered to decide on coverage capability of determined 20 demand points and 20 potential bike stations. Then, the mathematical models of P-center and P-median are used to build possible stations and to allocate demand points to the opened stations. Finally, an undesirable facility location model is used to find the bike stations, which have the maximum distance from demand nodes, and to eliminate them. Results: In computational results, it is clearly seen that the proposed approaches set the potential bike station covering all demand points. They also provide different solutions for the campus planners. Conclusions: The methodology outlined in this study can provide university administrators with a useful insight into locations of stations, and in this way, it contributes significantly to future planning of bike-sharing systems.
Labour market flexibility and FDI attraction: A macroeconomic analysis

Foreign direct investment is one mode of entry into international markets that can provide important benefits to host economies. For this reason, policymakers have sought to apply policies that attract foreign direct investment. Although there is extensive and relevant literature that explores the determinants of foreign direct investment, few studies exist that focus on the relationship between labour market flexibility and foreign direct investment;furthermore, most of these are firm-level studies and use old data. Thus, this study aims to analyze the influence of labour market flexibility on foreign direct investment based on macroeconomic data for a set of 180 countries and a relatively recent period of analysis (2004-2009). Using econometric techniques with panel data, the results show that labour market flexibility enhances the attraction of foreign direct investment. In particular, the rigidity of working hours is the dimension of labour market regulations that most negatively affects the attraction of foreign direct investment. Based on the control variables used, we found that the economic and financial incentives, trade barriers, the growth and the size of the market and the level of human capital are important determinants in the explanation of foreign direct investment patterns. Keywords: Foreign direct investment, Location determinants, Labour market flexibility, Labour regulations.JEL: F21, J80.
What do we know about urban sustainability? A research synthesis and nonparametric assessment

Urban sustainability has become a burgeoning practical and scholarly enterprise over the last two decades. Yet, there have been few attempts to systematically assess what cumulative knowledge this research is generating. We advance our understanding of urban sustainability by synthesising extant empirical findings to gauge progress made towards developing theoretical insight, and then testing a nonparametric predictive model that helps overcome methodological challenges in this literature. Drawing data from two national surveys of US local governments, we find that although organisational capacity appears to be the most important predictor, the broad range of activities grouped under the banner of ‘urban sustainability’ rely on distinct causal mechanisms, and use of composite models and measures of sustainability may hinder theoretical advancement. Implications for future research are discussed.
RESEARCH ARTICLE: Up‐regulation of Adenosine Receptors in the Frontal Cortex in Alzheimer's Disease

Adenosine receptors are G‐protein coupled receptors which modulate neurotransmitter release, mainly glutamate. Adenosine A1 and A2A receptors were studied in post‐mortem human cortex in Alzheimer's disease (AD) and age‐matched controls. Total adenosine A1 receptor number, determined by radioligand binding assay, using [3H]DPCPX, was significantly increased in AD cases in early and advanced stages without differences with the progression of the disease. A significant increase of A1R (37 kDa) levels was also observed by Western blot in early and advanced stages of AD. In addition, increased numbers of adenosine A2A receptors were observed in AD samples as determined by a binding assay using [3H]ZM 241385 as a radioligand and by Western blot. Increased binding and protein expression levels of adenosine receptors were not associated with increased mRNA levels coding A1 and A2A receptors. Finally, increased A1 and A2A receptor‐mediated response was observed. These results show up‐regulation of adenosine A1 and A2A receptors in frontal cortex in AD, associated with sensitization of the corresponding transduction pathways.
Differences between Patients with TB-Destroyed Lung and Patients with COPD Admitted to the ICU

Background: Although patients with tuberculous-destroyed lung (TDL) account for a significant proportion of those with chronic airflow obstruction, it is difficult to distinguish patients with airway obstruction due to TDL from patients with pure chronic obstructive pulmonary disease (COPD) on initial presentation with dyspnea. We investigated clinical features differing between (i) patients with TDL and airway obstruction and (ii) those with COPD admitted to the intensive care unit (ICU) due to dyspnea. Methods: We reviewed the medical records of patients with TDL who had a forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) of ＜70% on a pulmonary function test (PFT; best value closest to admission) and patients with COPD without a history of pulmonary tuberculosis (TB) who were admitted to the ICU. Ultimately, 16 patients with TDL and 16 with COPD were compared, excluding patients with co-morbidities. Results: The mean ages of the patients with TDL and COPD were 63.7 and 71.2 years, respectively. Mean FVC% (50.4% vs. 71.9%; p＜0.01) and mean FEV1% (39.1% vs. 58.4%; p＜0.01) were significantly lower in the TDL group than in the COPD group. More frequent consolidation with TB (68.8% vs. 31.3%; p=0.03) and more tracheostomies (50.0% vs. 0.0%; p=0.02) were observed in the TDL than in the COPD group. Conclusion: Upon ICU admission, patients with TDL had TB pneumonia more frequently, more diminished PFT results, and more tracheostomies than patients with COPD.
Millennials’ Entrepreneurial Values, Entrepreneurial Symbiosis Network and New Ventures Growth: Evidence From China

The fate of new ventures incubated by the same corporate ecosystem is different. Can entrepreneurs’ ideas affect the way out of incubating companies? Based on self-verification theory and symbiosis theory, we took millennial entrepreneurs as the research object, combined with entrepreneurial enterprises’ data in the makerspace. We analyzed the impact of millennials’ entrepreneurial values on new ventures growth and explored the mediating role of entrepreneurial symbiosis networks. The following conclusions are obtained by analyzing the questionnaire of 191 millennial entrepreneurs: Millennials’ entrepreneurial values significantly promote new ventures growth. The strength and scale of the entrepreneurial symbiosis network have a positive impact on new ventures growth. The entrepreneur symbiosis network acts as an intermediary between the millennials’ entrepreneurial values and new ventures growth.
Cerebral Microbleeds and Depression in Lacunar Stroke

Background and Purpose— Cerebral microbleeds (CMB) are common in stroke survivors and the community-dwelling elderly. The clinical significance of CMB in the development of depression after a stroke is unknown. This study examined the association between poststroke depression (PSD) and CMB. Methods— A cohort of 235 patients with acute lacunar stroke admitted to the stroke unit of a university-affiliated regional hospital in Hong Kong was recruited. Three months after the onset of the index stroke, a research assistant administered the locally validated 15-item Geriatric Depression Scale. PSD was defined as a Genetic Depression Scale score of ≥7. The presence and location of CMB were evaluated with MRI. Results— In comparison with the non-PSD group, PSD patients were more likely to have lobar CMB (33.3% versus 19.9%; P=0.022). Lobar CMB remained an independent predictor of PSD in the multivariate analysis, with an odds ratio of 2.08 (P=0.032). Conclusions— The results suggest that lobar CMB may play a role in the development of PSD. The importance of CMB in the pathogenesis of depression in stroke survivors and the general elderly population warrants further investigation.
[Evaluation of the risk of clonorchiasis inducing primary hepatocellular carcinoma].

OBJECTIVE To explore the relationship between clonorchiasis and primary hepatocellular carcinoma (HCC) and analyze the synergistic actions of HBV infection, alcohol consumption and clonorchiasis on HCC development. METHODS This hospital-based case-control study was conducted among 444 HCC patients (cases) and 500 non tumor patients (controls) to compare the prevalence of clonorchiasis in the cases and the controls. The risk of clonorchiasis and the synergistic actions between HBV infection, alcohol consumption and clonorchiasis on HCC development were analyzed by crossover analysis and multiple logistic regression. RESULTS The prevalence of clonorchiasis in the cases (16.44%) was much higher than that of the controls (2.40%) (X2 = 56.58, P less than 0.01). In the case group, the OR value of those with clonorchiasis was 8.00 (95% CI: 4.34-14.92). The OR value was 4.82 (95% CI: 2.32-10.26) for the subjects whose clonorchiasis was diagnosed less than 10 years before their diagnosis of HCC, and was 17.54 (95% CI: 5.47-57.18) for those whose HCC was diagnosed more than 10 years ago. HBV infection, alcohol consumption and clonorchiasis showed an additive interaction in the development of HCC, with a relative excess risk of interaction of 110.43 and 18.23; attributable proportion of interaction of 0.80 and 0.63; synergy index of 5.18 and 2.84, respectively. CONCLUSION Clonorchiasis could be an important risk factor for HCC. When the course of clonorchiasis is prolonged, the risk of HCC could increase. HBV infection, alcohol consumption and clonorchiasis might have synergistic actions on the development of HCC.
THE DILEMMA OF CRITICISM: DISENTANGLING THE DETERMINANTS OF MEDIA CENSORSHIP IN CHINA

Abstract Recent literature claims that China censors information that has the potential to ignite collective action. This article extends this finding by arguing that Chinese censors respond differently to political challenges than they do to performance challenges. Political challenges call into questioning the Party's leading role, whereas performance challenges are directed at the failures of public goods provisions. A survey experiment of about 60 media professionals finds that censors are inclined to block political challenges and to tolerate criticism of the government's performance. However, when criticism contains both performance and political challenges, censorship is far more likely. By exploring the range of censorship activities, the results suggest that the Chinese regime's reliance on popular support constrains its censorship decisions.
Targeting Extracellular Cyclophilin A Reduces Neuroinflammation and Extends Survival in a Mouse Model of Amyotrophic Lateral Sclerosis

Neuroinflammation is a major hallmark of amyotrophic lateral sclerosis (ALS), which is currently untreatable. Several anti-inflammatory compounds have been evaluated in patients and in animal models of ALS, but have been proven disappointing in part because effective targets have not yet been identified. Cyclophilin A, also known as peptidylprolyl cis-/trans-isomerase A (PPIA), as a foldase is beneficial intracellularly, but extracellularly has detrimental functions. We found that extracellular PPIA is a mediator of neuroinflammation in ALS. It is a major inducer of matrix metalloproteinase 9 and is selectively toxic for motor neurons. High levels of PPIA were found in the CSF of SOD1G93A mice and rats and sporadic ALS patients, suggesting that our findings may be relevant for familial and sporadic cases. A specific inhibitor of extracellular PPIA, MM218, given at symptom onset, rescued motor neurons and extended survival in the SOD1G93A mouse model of familial ALS by 11 d. The treatment resulted in the polarization of glia toward a prohealing phenotype associated with reduced NF-κB activation, proinflammatory markers, endoplasmic reticulum stress, and insoluble phosphorylated TDP-43. Our results indicates that extracellular PPIA is a promising druggable target for ALS and support further studies to develop a therapy to arrest or slow the progression of the disease in patients. SIGNIFICANCE STATEMENT We provide evidence that extracellular cyclophilin A, also known as peptidylprolyl cis-/trans-isomerase A (PPIA), is a mediator of the neuroinflammatory reaction in amyotrophic lateral sclerosis (ALS) and is toxic for motor neurons. Supporting this, a specific extracellular PPIA inhibitor reduced neuroinflammation, rescued motor neurons, and extended survival in the SOD1G93A mouse model of familial ALS. Our findings suggest selective pharmacological inhibition of extracellular PPIA as a novel therapeutic strategy, not only for SOD1-linked ALS, but possibly also for sporadic ALS. This approach aims to address the neuroinflammatory reaction that is a major hallmark of ALS. However, given the complexity of the disease, a combination of therapeutic approaches may be necessary.