Miracle-dz/UniFAR-FTUs huggingface dataset:
Direct numerical Simulation of nonhomogeneous separated fluid flows

For solving of the Navier-Stokes equations describing 3D incompressible viscous fluid flows the Splitting on physical factors Method for Incompressible Fluid flows (SMIF) with hybrid explicit finite difference scheme (second-order accuracy in space, minimum scheme viscosity and dispersion, capable for work in wide range of Reynolds Re and Froude Fr numbers and monotonous) based on Modified Central Difference Scheme and Modified Upwind Difference Scheme with special switch condition depending on the velocity sign and the signs of the first and second differences of transferred functions has been developed and successfully applied (V.A. Gushchin, V.N. Konshin: Computational aspects of the splitting method for incompressible flow with a free surface. Journal of Computers and Fluids , 21 (3) (1992), 345-353). For the visualization of the 3D vortex structures in the fluid flows the isosurfaces of β have been drawing, where β is the imaginary part of the complex-conjugate eigen-values of the velocity gradient tensor. The numerical method SMIF has been successfully applied for solving of the different problems on supercomputers: 2D fluid flows with a free surface, 3D separated homogeneous and stratified fluid flows around a sphere and a circular cylinder; the air, heat and mass transfer in the clean rooms. For example in the case of the homogeneous fluid the detailed formation mechanisms of vortices in the sphere wake at 200 < Re < 1000 have been described in (V.A. Gushchin, P.V. Matyushin: Vortex formation mechanisms in the wake behind a sphere for 200 < Re < 380. Fluid Dynamics , 41 (5) (2006), 795-809). In the case of the stratified fluid the classification of flow regimes around sphere at Fr < 10, Re < 500 has been refined (V.A. Gushchin, P.V. Matyushin: Numerical Simulation and Visualization of Vortical Structure Transformation in the Flow past a Sphere at an Increasing Degree of Stratification. Comput. Math. and Math. Physics , 51 (2) (2011), 251-263). This work has been supported by Russian Foundation for Basic Research (grant 11-01-00764), by the grants from the Presidium of RAS and the Dep. of Mathemat. Sciences of RAS.
Factors Affecting Students’ Attitudes towards E-Learning

E-learning is becoming a widespread method of gaining knowledge in a global environment. Accessibility and variety of online content encourage more people to get involved in learning from digital resources. However, there has been limited research exploring the factors that could influence students’ attitudes regarding e-learning. In this study, field research was conducted to determine which factors affect students’ attitudes towards e-learning. The questionnaire was developed to collect data about factors that influence attitudes towards e-learning. A total of 286 students were the study cohort. Three factors were identified using principal component analysis: e-learning usefulness, ease of use, and content design. Regression analysis was conducted to determine the strength of the factors influencing attitudes towards e-learning. All factors had a significant influence on attitude towards e-learning. Usefulness of e-learning had the strongest impact on students’ e-learning intention. Our study will contribute to the existing work in this field by emphasizing the importance of perception of content design on attitudes towards e-learning.
Longitudinal Change of DAT SPECT in Parkinson's Disease and Multiple System Atrophy.

BACKGROUND Both Parkinson's disease (PD) and multiple system atrophy (MSA) are neurodegenerative disorder affecting striatonigral system. Although various lines of evidence demonstrate that dopaminergic neuron degeneration emerges before the onset of motor symptoms in PD, preclinical/prodromal progression of neurodegeneration is far less understood in MSA. OBJECTIVE The aim of this study was to clarify the difference in the progression of dopaminergic degeneration in MSA and PD using dopamine transporter single-photon emission computed tomography (DAT SPECT). METHODS We analyzed longitudinal data of the specific binding ratio (SBR), a measure of striatal radiotracer uptake, in DAT SPECT from 7 patients with MSA-C, 5 patients with MSA-P, and 18 patients with PD. We performed 2.7±0.7 scans with an interval of 9.85±6.00 months for MSA and 2 scans with an interval of 2.16±0.16 years for PD. RESULTS The rate of SBR decline was faster in both subtypes of MSA compared with PD, but the value was similar between MSA-P and MSA-C. The estimated SBR at the onset of initial motor symptoms was lower in PD and MSA-P than in MSA-C, especially in the predominantly affected side. SBR of the predominantly affected side starts to decrease before the onset of motor symptoms in PD and MSA-P, whereas the initiation of SBR decline is around the onset in MSA-C individuals. The decline of SBR in the less affected side was not clearly shown before the onset in MSA-P or MSA-C. CONCLUSIONS Our results suggest that the SBR in DAT SPECT analysis is an important pathophysiological marker reflecting the disease- and subtype-specific progression of dopaminergic degeneration in MSA and PD.
PA—Precision Agriculture: Convective and Ventilation Transfers in Greenhouses, Part 1: the Greenhouse considered as a Perfectly Stirred Tank

In thispaper, the characterization and modelling of the most relevant convective transferscontributing to the elaboration of the greenhouse climate are reviewed. Convective transfers include heat and mass transfers between air and solid surfaces (walls, roof, leaves) along with air, heat, water vapour and tracer gas transfers to or from the inside air. Adopting the assumption that the greenhouse is a perfectly stirred tank, the specific characterization methods associated with this approach are reviewed. The perfectly stirred tank approach requires the assumption of uniform temperature, humidity and CO2 content inside the greenhouse and uses a ‘big leaf’ model to treat the plant canopy and describe the exchanges of latent and sensible heat with inside air. The simulation of the ventilation processes associated with this simplified approach is based on the Bernoulli equation and on the experimental determination of semi-empirical parameters by means of air exchange rate measurements. The techniques used to measure temperature and air exchange rates measurements pertaining to the whole greenhouse volume are presented. A complete panorama of the studies in relation to the transfer coefficients between the different surfaces together with the ventilation performances of various greenhouse types are also presented. This paper is the first part of a review of the convective transfers in greenhouses and in the second paper, a similar study based on the approach of the distributed climate is presented. # 2002 Silsoe Research Institute.
Preparation and characterization of aceclofenac microspheres

The objective of the present study was to microencapsulate the anti-inflammatory drug (aceclofenac) to provide controlled release and minimizing or eliminating local side effect by avoiding the drug release in the upper gastrointestinal track. The drug was targeted to the colon and their aligned area for their local effect. Aceclofenac was microencapsulated with Eudragit (S 100, RL 100, and RS 100), using an O/W emulsion-solvent evaporation technique. Aceclofenac microspheres were subjected to micromeritic properties including angle of repose, bulk density, tapped density, Carr’s index, Hausner’s ratio, and particle size determination. Microspheres were subjected to drug loading, in vitro drug release as well as for scanning electron microscopy.The prepared microspheres were white, free-flowing, and almost spherical in shape.The drug- loaded microspheres show 60-82% drug entrapment, angle of repose was in the range of 16.13 ± 0.621-24 ± 0.590, bulk and tapped densities respectively were in the range of 0.311 ± 0.006-0.562 ± 0.012 and 0.373 ± 0.01-0.735 ± 0.02, Carr’s index ranges from 14.04 ± 0.026 to 27.25 ± 1.405, Hausner’s ratio was 1.14 ± 0.026-1.37 ± 0.03, and particle size was in the range of 79.7016-144.840 μm. In vitro drug release studies were carried out up to 24 h in three different pH media, i.e., 0.1 N HCl (pH 1.2), phosphate buffer (pH 6.8), and phosphate buffer (pH 7.4). The drug-polymer concentration of dispersed phase influences the particle size and drug release properties. All the formulations at higher pH were followed by the Matrix-Higuchi model.
Effect of phosphorus on the concentrations of arsenic, iron and some other elements in barley grown hydroponically

Abstract Hydroponic barley ( Hordeum vulgare L. cv. minorimugi) was treated with 10 µM arsenic (As) together with 500, 250, 50 and 0 µM phosphorus (P) for 14 days to observe the response of the seedlings. The plants were also treated with 0 µM As + 0 µM P. Iron (Fe)-plaque was visible in the roots under As-treated and P-depleted conditions. The intensity of reddish coloration in the roots decreased with increasing P in the media. However, reddish coloration was not found in the absence of both As and P. The results show that both As and P played a vital role in the formation of Fe-plaque. Additionally, Fe-plaque formation was dependent on the concentration of P in the media. Iron concentration in the roots of the As treated plants without P was higher than that observed in the roots treated with 0 µM As + 0 µM P which suggests that As may have been adsorbed with Fe on the surface of roots, forming Fe-plaque. Arsenic concentration in the shoots and the roots was low under 500 and 250 µM P conditions while high under 50 and 0 µM P conditions. It was found that a higher concentration of P (50 µM; 5 times of As level) was required in the medium to reduce As concentration in the plant tissues.
In vivo uterine local gene delivery system using TAT‐displaying bionanocapsules

The uterus is an organ that is directly accessible via the transvaginal route, whereas the drug delivery system and the gene delivery system (GDS) for the uterus are very limited, even in animal models. In the present study, we optimized a bionanocapsule (BNC) comprising a hepatitis B virus envelope L‐protein particle, for which a structurally similar particle has been used as an immunogen of a conventional HB vaccine worldwide for more than 30 years, as a local uterine GDS using a mouse model.
Wnt Signalling in Acute Myeloid Leukaemia

Acute myeloid leukaemia (AML) is a group of malignant diseases of the haematopoietic system. AML occurs as the result of mutations in haematopoietic stem/progenitor cells, which upregulate Wnt signalling through a variety of mechanisms. Other mechanisms of Wnt activation in AML have been described such as Wnt antagonist inactivation through promoter methylation. Wnt signalling is necessary for the maintenance of leukaemic stem cells. Several molecules involved in or modulating Wnt signalling have a prognostic value in AML. These include: β-catenin, LEF-1, phosphorylated-GSK3β, PSMD2, PPARD, XPNPEP, sFRP2, RUNX1, AXIN2, PCDH17, CXXC5, LLGL1 and PTK7. Targeting Wnt signalling for tumour eradication is an approach that is being explored in haematological and solid tumours. A number of preclinical studies confirms its feasibility, albeit, so far no reliable clinical trial data are available to prove its utility and efficacy.
ENHANCED ADAPTIVE CHOICE-BASED CONJOINT ANALYSIS INCORPORATING ENGINEERING KNOWLEDGE

Conjoint analysis from marketing has been successfully integrated with engineering analysis in design for market systems. The long questionnaires needed for conjoint analysis in relatively complex design decisions can become cumbersome to the human respondents. This paper presents an adaptive questionnaire generation strategy that uses active learning and allows incorporation of engineering knowledge in order to identify efficiently designs with high probability to be optimal. The strategy is based on viewing optimal design as a group identification problem. A running example demonstrates that a good estimation of consumer preference is not always necessary for finding the optimal design and that conjoint analysis could be configured more effectively for the specific purpose of design optimization. Extending the proposed method beyond a homogeneous preference model and noiseless user responses is also discussed.
Safety of Intravenous Thrombolysis for Acute Ischemic Stroke in Patients with Thrombocytopenia

Background: Intravenous thrombolysis with recombinant tissue plasminogen activator (rtPA) is an effective treatment of acute ischemic stroke (AIS). The safety of intravenous rtPA in patients with thrombocytopenia is unclear. This study sought to evaluate the impact of thrombocytopenia on in-hospital outcomes in patients with AIS who received intravenous thrombolysis. Methods: This was a retrospective study using the 2012–2014 National Inpatient Sample (20% stratified sample of US hospitals). The study identified adult patients admitted with AIS who received intravenous rtPA during hospitalization. The identified admissions were stratified into 2 cohorts based on the presence or absence of thrombocytopenia. Multilevel, multivariate regression analysis and propensity matching were performed to evaluate in-hospital mortality, length of stay, and in-hospital complications. Results: Of 101,527 patients admitted for AIS and received intravenous rtPA from 2012 to 2014, 3,520 (3.47%) had thrombocytopenia. In-hospital mortality was 10.8 vs. 6.9% in patients with and without thrombocytopenia in original data, p < 0.001. In-hospital length of stay was significantly higher in the thrombocytopenia group (5.9 vs. 8.2 days, p < 0.001). The differences were significant in both the multivariate regression model and the propensity score matching model. Patients with thrombocytopenia also had a statistically higher incidence of intracranial hemorrhage, postprocedural bleeding, blood transfusion, tracheotomy, and mechanical ventilation. Conclusion: Thrombocytopenia is associated with higher in-hospital mortality, longer length of stay, a higher incidence of intracranial hemorrhage, postprocedural bleeding, and mechanical ventilation in stroke patients who received intravenous rtPA.
Nurses' Evidence-based Practice Knowledge, Attitudes, and Implementation: A Cross-sectional Study.

AIM AND OBJECTIVES To examine the influence of staff nurses' individual factors on knowledge, attitudes, and implementation of evidence-based practice in Saudi Arabia and to identify facilitators and barriers to evidence-based practice implementation. BACKGROUND Evidence-based practice has been considered as a key for health care quality measure. The literature, however, shows that nurses worldwide are not implementing evidence-based practice as expected and recommended by governing agencies. In Saudi Arabia, evidence-based practice implementation has not been addressed sufficiently. DESIGN A cross-sectional, correlational design was used. We have complied with the guidelines of STROBE Checklist in presenting this research. A convenience sample of staff nurses (n = 227) was selected from four hospitals in Riyadh, Saudi Arabia. The survey questions included the Evidence-based Practice Questionnaire and individual factors. Data was analyzed using multiple linear regression models. RESULTS Attitudes toward evidence-based practice had the highest mean followed by evidence-based practice knowledge and implementation means. Evidence-based practice training and research involvement were associated with knowledge in the bivariate and multivariate analyses. None of the individual factors were associated with attitudes. However, knowledge was associated with attitudes. Knowledge and attitudes influenced evidence-based practice implementation positively. Unexpectedly, receiving evidence-based practice training made it more difficult for nurses to participate in evidence-based practice implementation process. We found that attitudes partially mediated the relationship between knowledge and evidence-based practice implementation. CONCLUSION Nurses in Saudi Arabia are willing to be involved in the evidence-based practice process. However, nurses identified that they need to improve their knowledge and skills in order to be active participants in the process. RELEVANCE TO CLINICAL PRACTICE Organizations and nursing leadership may benefit from developing a comprehensive strategy to promote staff nurses' involvement in the evidence-based practice process through providing continuing education and mentoring programs about evidence-based practice.
Ultrastructure of the pollen grains of Withania somnifera (L.) Dunal (Solanaceae), A study from Saudi Arabia

Light microscopy, scanning and transmission electron microscopy were used to study the morphology and theultrastructure of the pollen grains of Withania somnifera (L.) Dunal. Light microscopic examination revealed that thepollen grain is tri- or tetrazonocoplate, approximately as long as broad measuring 29-μm. Scanning electron microscopic observation showed that surface sculpture is scarbate granulate. Ultrathin sections as examined by transmission electron microscope showed that the pollen contained numerous starch grains, liped drops, endoplasmic reticulum and vesicles of dicotysomes. Two layers of pollen wall were also distinguished; the outer wall (exine divided into ektexine and enexine as well as an inner layer (intine). The nutritive values of Withania pollen were discussed. The importance of studying the ultrastructure of pollen grains as a new tool in plant taxonomy was alsodiscussed.
Influence of Work Environment , Motivation and Career Development on the Work Achievement on a Timeless Gift Pt . Aligned

The purpose of this research is to know and test whether there is influence of work environment, career development, and motivation toward accomplishment of work on PT Abadi Sidoarjo Aligned Gifts. The research correlation coefficient Pearson product moment. Sample collection techniques using random sampling techniques of data collection. Used a questionnaire. Data were analyzed using validity test, reliability test, outlier test variation outlier test, test multivariate, normality, data analysis is the path diagram that will make it easier to see the causality to be tested by using SEM (Structural Equation Modeling) Based on the analysis of the data of the research is, it is known that the work environment a positive effect on the work achievement at PT. Gifts Aligned man of Sidoarjo, positive effect on motivation work achievement on a Timeless PT. Gift Aligned Sidoarjo, positive effect on career development achievements work on Eternal PT. Gift Aligned Sidoarjo.
A clinical approach to multidrug-resistant urinary tract infection and subclinical bacteriuria in dogs and cats

ABSTRACT Multidrug-resistant bacteria are increasingly isolated from the urinary tract of pets, particularly those that suffer from concurrent conditions, have been hospitalised, or were treated with antimicrobials in the recent past. Many of the multidrug-resistant bacteria encountered are resistant to all commonly used oral antibiotics. This poses both a therapeutic dilemma in the individual pet and a threat to public health. This article begins with an overview of multidrug resistance in organisms that are commonly isolated from the urinary tract of pets. This is followed by a proposed clinical approach to managing multidrug-resistant urinary bacteria, which summarises current knowledge regarding appropriate sampling and analysis, reviews the current guidelines regarding appropriate antimicrobial use and discusses treatment options that might be considered. The article highlights several shortcomings of the current knowledge to be considered when planning future clinical research and developing policies.
Investigation of Deep Indoor NB-IoT Propagation Attenuation

Reliable connectivity over large distances is one of the main features characterising Low-Power Wide Area Network (LP-WAN) technologies, with Narrowband Internet of Things (NB-IoT) as the most promising one. The advent of such a family of communication standards has attracted attention of the industry, as excellent coverage of LP-WAN potentially enables new opportunities of automation, for instance remote metering or asset tracking. However, telecommunication standardisation bodies are still lacking accurate models of signal attenuation in deep-indoor environments. This work attempts to address this gap by presenting experimental measurements on NB-IoT deep-indoor signal attenuation. The results indicate the differences in signal propagation between underground and above-ground indoor scenarios.
Campylobacter armoricus sp. nov., a novel member of the Campylobacter lari group isolated from surface water and stools from humans with enteric infection.

During a study on the prevalence and diversity of members of the genus Campylobacter in a shellfish-harvesting area and its catchment in Brittany, France, six urease-positive isolates of members of the genus Campylobacter were recovered from surface water samples, as well as three isolates from stools of humans displaying enteric infection in the same period. These strains were initially identified as members of the Campylobacter lari group by MALDI-TOF mass spectrometry and placed into a distinct group in the genus Campylobacter, following atpA gene sequence analysis based on whole-genome sequencing data. This taxonomic position was confirmed by phylogenetic analysis of the 16S rRNA, rpoB and hsp60 (groEL) loci, and an analysis of the core genome that provided an improved phylogenetic resolution. The average nucleotide identity between the representative strain CA656T (CCUG 73571T=CIP 111675T) and the type strain of the most closely related species Campylobacter ornithocola WBE38T was 88.5 %. The strains were found to be microaerobic and anaerobic, motile, non-spore-forming, Gram-stain-negative, spiral-shaped bacteria that exhibit catalase, oxidase and urease activities but not nitrate reduction. This study demonstrates clearly that the nine isolates represent a novel species within the C. lari group, for which the name Campylobacter armoricus is proposed. Here, we present phenotypic and morphological features of the nine strains and the description of their genome sequences. The proposed type strain CA656T has a 1.589 Mbp chromosome with a DNA G+C content of 28.5 mol% and encodes 1588 predicted coding sequences, 38 tRNAs, and 3 rRNA operons.
Ammonium transceptors: Novel regulators of fungal development

Transceptors are nutrient transporters that act as receptors to regulate downstream signaling pathways. Ammonium transceptors regulate fungal morphology in response to limiting levels of ammonium, which is utilized as a nitrogen source. Few studies have addressed to what extent ammonium transceptors are conserved in pathogenic fungi. Plant and animal fungal pathogens undergo a variety of developmental transitions during infection, and work on some plant fungal pathogens establishes the importance of ammonium transporters during host infection [1, 2]. More widespread studies are needed to determine if ammonium transceptors have a general role in regulating the virulence of fungal pathogens.