Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Forearm vs. Leg Submersion in Work Tolerance Time in a Hot Environment While Wearing Firefighter Protective Clothing

This study compared physiological responses and total work tolerance time following forearm submersion (FS) or leg submersion (LS) in cool water, after performing work in a hot environment while wearing fire fighting protective clothing (FPC). Participants walked at 3.5 mph on a treadmill in a hot environment (WBGT 32.8 ± 0.9°C) until a rectal temperature (Trec) of 38.5°C was reached. Participants were then subjected to one of two peripheral cooling interventions, in a counterbalanced order. Forearms or lower legs were submerged in water (16.9 ± 0.8°C) for a total of 20 min, followed by a work tolerance trial. Results indicated no significant difference (p = 0.052) between work tolerance time (LS = 21.36 ± 5.35 min vs. FS = 16.27 ± 5.56 min). Similarly, there was no significant difference for Trec (p = 0.65), heart rate (HR) (p = 0.79), mean skin temperature (Tsk) (p = 0.68), and rating of perceived exertion (RPE) (p = 0.54). However, LS ratings of thermal comfort (RTC) at Minute 14 (p = 0.03) were significantly lower for LS (10 ± 1) vs. FS (12 ± 1). Results indicate little difference between FS and LS for physiological measures. Despite a lack of statistical significance a 5-min (24%) increase was found during the work tolerance time following LS.
Compute-Compress-and-Forward: New Results

In this paper, we consider the design of compression functions for compute-and-forward (CF) based relaying. We develop a general compressing framework, termed generalized compute-compress-and-forward (GCCF), where the compression function involves multiple quantization- and-modulo lattice operations. We show that GCCF achieves a broader compression rate region than CCF. We also compare our compression rate region with the fundamental Slepian-Wolf (SW) region. We show that GCCF is optimal in the sense of achieving the minimum total compression rate. We also establish the criteria under which GCCF achieves the SW region. In addition, we consider a two-hop relay network employing the GCCF scheme. Numerical results are presented to demonstrate the performance superiority of GCCF over other schemes.
Comparison of a new, minimally invasive strabismus surgery technique with the usual limbal approach for rectus muscle recession and plication

Aim: To present a novel, minimally invasive strabismus surgery (MISS) technique for rectus muscle operations. Methods: In this prospective study with a non-concurrent, retrospective comparison group, the first 20 consecutive patients treated with MISS were matched by age, diagnosis and muscles operated on, with 20 patients with a limbal opening operated on by the same surgeon at Kantonsspital, St Gallen, Switzerland. A total of 39 muscles were operated on. MISS is performed by applying two small radial cuts along the superior and inferior muscle margin. After muscle separation from surrounding tissue, a recession or plication is performed through the resulting tunnel. Alignment, binocular single vision, variations in vision, refraction, and number and types of complications during the first 6 postoperative months were registered. Results: Visual acuity decreased at postoperative day 1 in both groups. The decrease was less pronounced in the group operated on with MISS (difference of decrease 0.14 logMAR, p<0.001). An abnormal lid swelling at day 1 was more frequent in the control group (21%, 95% confidence interval (CI) 9% to 41%, 5/24 v 0%, 95% CI 0 to 13%, 0/25, p<0.05). No significant difference was found for final alignment, binocular single vision, other visual acuities, refractive changes or complications (allergic reactions, dellen formation, abnormal conjuctival findings). A conversion to a limbal opening was necessary in 5% (95% CI 2% to 17%, 2/39) of muscles. Conclusions: This study shows that this new, small-incision, minimal dissection technique is feasible. The MISS technique seems to be superior in the direct postoperative period as better visual acuities and less lid swelling were observed. Long-term results did not differ in the two groups.
Relationship between the prostatic tissue components and natural history of benign prostatic hyperplasia.

OBJECTIVE Few reports have been published on the relationship between prostatic tissue components and the natural history of benign prostatic hyperplasia (BPH). The present study was undertaken to evaluate this relationship. STUDY DESIGN Forty-nine patients with BPH who underwent suprapubic prostatectomy were studied. Six infant prostates and 10 non-BPH specimens were obtained from autopsy. Specimens were stained with antibodies to alpha-smooth muscle actin, and the mean ratio of the stroma was determined with computer image analysis. Stromal ratios were evaluated according to resected prostate weight and age. RESULTS The stroma comprised 82.6 +/- 8.4% of the prostate area at 0-1 year of age and 43.7 +/- 5.1% at 15-28 years of age. In BPH, the stromal proportion increased to 55.9 +/- 10.2%, but decreased with increases in prostate weight and/or age. CONCLUSION The stromal component increased in patients with BPH and decreased with increased prostate weight and/or age, comprising approximately 42-47% of the prostate area, as in the non-BPH prostate, indicating a balance in prostatic tissue components in both patients with BPH and the non-BPH prostate.
In vivo glucocorticoid effects on porcine natural killer cell activity and circulating leukocytes.

Porcine natural killer (NK) cell cytotoxicity, plasma cortisol, total white blood cells (WBC), neutrophil:lymphocyte ratio (N:L), and circulating blood leukocytes were examined from pigs injected i.v. with either saline, ACTH, cortisol, or treated with metyrapone. Plasma cortisol increased (P < .05) after ACTH and cortisol treatments and decreased (P < .05) after metyrapone treatment; thus, treatments had the intended effects on in vivo cortisol concentrations. In Exp. 1, pigs were injected with either saline or ACTH at 0600 after the initial blood samples were taken (time 0). The ACTH had no effect (P > .10) on NK cytotoxicity. Pigs injected i.v. with ACTH had fewer lymphocytes and more neutrophils (P < .05) than control pigs. The N:L ratio was greater (P < .05) among ACTH-injected than among control pigs. In Exp. 2, pigs were injected i.v. with either saline or 40 or 400 micrograms of cortisol at 0600 after the initial blood samples were obtained (time 0). Cortisol at 40 micrograms had no effect (P > .10) on NK cytotoxicity. However, a 400-micrograms bolus of cortisol reduced (P < .05) NK cytotoxicity (control = 39.5, cortisol = 28.3% cytotoxicity, SEM = 3.7). Each dose of cortisol reduced (P < .05) circulating blood lymphocyte numbers. In Exp. 3, pigs were fed 1 g of metyrapone or no metyrapone the night before sampling. Blood samples were obtained at 0600, 0700, and 0800. Metyrapone reduced (P < .05) NK cytotoxicity (control = 28.6, metyrapone = 11.8%, SEM = 1.9). Pigs treated with metyrapone had greater (P < .05) numbers of neutrophils than control pigs. Numbers of lymphocytes were greater (P < .05) among control than among treated pigs. Pigs treated with metyrapone had a greater (P < .05) N:L ratio than control pigs. In conclusion, normal physiological concentrations or moderately increased blood cortisol concentrations did not influence NK activity, although leukocyte distributions were changed. We conclude that greatly increased or greatly decreased circulating concentrations of cortisol reduced NK cytotoxicity.
A second-order Nyström-type discretization for the early-exercise curve of American put options

It is well known that the value of an American option can be expressed as the sum of the corresponding European option and a premium, which reflects the additional right of early exercise. Based on this expression, it is possible to derive an integral equation for the early-exercise curve. Because the early-exercise curve is not sufficiently smooth at expiry, an ad hoc Nyström discretization of high order for solving the integral equation is not guaranteed. In this paper, we present a Nyström-type discretization, which uses an adequate integral transformation to circumvent the non-sufficient smoothness at expiry and results in a method of second order.
Decision of response timing for incremental speech recognition with reinforcement learning

In spoken dialog systems, it is important to reduce the delay in generating a response to a user's utterance. We investigate the use of incremental recognition results which can be obtained from a speech recognition engine before the input utterance ends. To enable the system to respond correctly before the end of the utterance, it is desired to utilize the incremental results effectively, although they are not reliable enough. We formulate this problem as a decision making task, in which the system makes choices iteratively either to answer based on previous observations, or to wait until the next observation. The reinforcement learning can be applied to the problem. As the results of experiments, the users highly evaluate the proposed method which estimate completion time of a user's utterance by using the results of speech recognition based on mora units.
Site of penetrating brain lesions causing chronic acquired stuttering

Ten subjects exhibited acquired stuttering that had persisted for 10 to 15 years following penetrating missile wounds sustained during the Vietnam War. None had a history of developmental or chronic adult stuttering. In comparison with other head‐injured subjects and normal control subjects, the subjects with acquired stuttering had significant deficits in skilled rapid hand movements and oral and speech movements, suggesting a motor control disorder. The identified brain lesions of the acquired stuttering group were on the right in 5 subjects, on the left in 4, and bilateral in 1. The internal and external capsules, the frontal white matter, and the striatum were more frequently involved in the acquired stuttering group than in other head‐injured subjects (p ≤ 0.05). This speech rhythm and rate disorder was not associated with evident cortical lesions in either hemisphere but with predominantly unilateral lesions of the subcortical pyramidal and extrapyramidal systems.
Left atrial function as a reliable predictor of exercise capacity in patients with recent myocardial infarction.

STUDY OBJECTIVE To examine the relation between left atrial (LA) function and exercise performance. DESIGN AND SETTING Retrospective study at a referral cardiopulmonary exercise laboratory in a university hospital. PATIENTS Forty-one patients with recent myocardial infarction. INTERVENTIONS M-mode echocardiography and cardiopulmonary exercise testing combined with radionuclide ventriculography. MEASUREMENTS AND RESULTS Hemodynamic measurements were obtained at rest and peak exercise. LA fractional shortening at rest was used as an index of global LA function. LA fractional shortening had fair correlations with peak oxygen consumption (r=0.67, p<0.01) and exercise duration (r=0.71, p<0.01). Although there were no significant relations between LA fractional shortening and hemodynamic measurements at rest, LA fractional shortening was positively related to peak cardiac output (r=0.61, p<0.01) and peak stroke volume (r=0.57, p<0.01), and negatively related to peak pulmonary arterial wedge pressure (r=-0.44, p<0.05). In addition, LA fractional shortening correlated significantly with an increase in left ventricular (LV) end-diastolic volume from rest to peak exercise (r=0.48, p<0.02), but did not correlate with the changes in ejection fraction and end-systolic volume during exercise. An increase in LV end-diastolic volume during exercise was significantly related to peak oxygen consumption (r=0.46, p<0.02), peak cardiac output (r=0.60, p<0.01), and peak stroke volume (r=0.53, p<0.01), whereas the changes in ejection fraction and end-systolic volume during exercise were not related to these indexes. CONCLUSIONS Exercise capacity and LV performance during exercise were mainly dependent on LV diastolic filling rather than systolic contraction during exercise. LA fractional shortening at rest reflected LV diastolic filling during exercise and, therefore, predicted cardiac output and stroke volume responses to exercise and exercise capacity in patients with recent myocardial infarction.
Phospholipase D and Its Product, Phosphatidic Acid, Mediate Agonist-dependent Raf-1 Translocation to the Plasma Membrane and the Activation of the Mitogen-activated Protein Kinase Pathway*

The primary known function of phospholipase D (PLD) is to generate phosphatidic acid (PA) via the hydrolysis of phosphatidylcholine. However, the functional role of PA is not well understood. We report here evidence that links the activation of PLD by insulin and the subsequent generation of PA to the activation of the Raf-1-mitogen-activated protein kinase (MAPK) cascade. Brefeldin A (BFA), an inhibitor of the activation of ADP-ribosylation factor proteins, inhibited insulin-dependent production of PA and MAPK phosphorylation. The addition of PA reversed the inhibition of MAPK activation by BFA. Overexpression of a catalytically inactive variant of PLD2, but not PLD1, blocked insulin-dependent activation of PLD and phosphorylation of MAPK. Real time imaging analysis showed that insulin induced Raf-1 translocation to cell membranes by a process that was inhibited by BFA. PA addition reversed the effects of BFA on Raf-1 translocation. However, PA did not activate Raf-1 in vitro or in vivo, suggesting that the primary function of PA is to enhance the recruitment of Raf-1 to the plasma membrane where other factors may activate it. Finally, we found that the recruitment of Raf-1 to the plasma membrane was transient, but Raf-1 remained bound to endocytic vesicles.
Adiponectin attenuates human eosinophil adhesion and chemotaxis: implications in allergic inflammation

Abstract Objective: Growing evidence has shown an association between obesity and asthma. Adiponectin, an adipocyte-derived cytokine, is known to have anti-inflammatory effects with reduced concentrations in obese subjects. Recent findings raised the intriguing possibility that adiponectin might play a role in allergic inflammation, although the mechanistic basis for their relationship remains unclear. The purpose of this study was to examine whether adiponectin might affect functions of eosinophils, which play an important role in the pathogenesis of asthma. Methods: Human peripheral blood eosinophils were purified to study expression of adiponectin receptors AdipoR1 and AdipoR2 using RT-PCR and flow cytometry. The effect of adiponectin on eosinophil survival was investigated using annexin V and propidium iodide staining. Eotaxin-induced cell adhesion was investigated using ICAM-1-coated plates. A Boyden chamber and real-time horizontal migration system were used for eotaxin-directed chemotaxis assay. Expression of eotaxin receptor CCR3 and intracellular calcium influx were assessed by flow cytometry. Results: AdipoR1 and AdipoR2 were expressed in human eosinophils. Adiponectin did not affect eosinophil survival or CCR3 expression; however, eotaxin-enhanced adhesion was inhibited by pretreatment with adiponectin. Adiponectin also diminished eotaxin-directed chemotactic responses by disturbing both velocity and directionality. Calcium influx in response to eotaxin was attenuated by adiponectin. Conclusions: These results indicate that adiponectin attenuates the eosinophil functions induced by eotaxin without affecting cell viability. The inhibitory effect was associated with diminished calcium signaling rather than altering of surface receptor expression. Increasing circulating adiponectin might be a novel therapeutic modality for treatment of asthma, especially in obese asthmatics.
Power and area efficient comb-based decimator for Sigma-Delta ADCs with high decimation factors

This paper introduces a power and area efficient comb-based decimation structure, particularly suited for high values of decimation factors which are a power of two. The proposed topology has two stages, where the first stage is in a non-recursive form and the second one is in a recursive form (CIC filter). Moreover, a slight modification of the proposed decimator structure is presented in order to obtain an improved alias rejection. Simulation results are shown to validate the proposed approach.
Prospective association between β2-microglobulin levels and ischemic stroke risk among women

Objective: To determine whether elevated β2-microglobulin (B2M) levels were associated with an increased risk of incident ischemic stroke events among women. Methods: We performed a nested case-control study among women enrolled in the Nurses' Health Study who provided blood samples between 1989 and 1990 and were free of prior stroke and cancer. We measured B2M levels in 473 ischemic strokes cases confirmed by medical record review and in 473 controls matched 1:1 to the cases on age, race, date of blood collection, menopausal status, postmenopausal hormone use, and smoking status. We analyzed the association between B2M and ischemic stroke using multivariable conditional logistic regression to adjust for traditional stroke risk factors. Results: Median levels of B2M were higher among cases (1.86 mg/L) than controls (1.80 mg/L, p = 0.009, Wilcoxon rank-sum test). Women in the highest B2M quartile had a multivariable-adjusted increased risk of ischemic stroke compared to those in the lowest quartile (odds ratio [OR] 1.56, 95% confidence interval [CI] 1.02–2.39). Results were similar when restricted to those without evidence of chronic kidney disease (estimated glomerular filtration rate ≥60 mL·min−1·1.73 m−2) (OR 1.49, 95% CI 1.08–2.06). In an exploratory analysis, the association between B2M and thrombotic stroke was similar to the overall ischemic stroke results, but no association was observed for embolic stroke risk. Conclusion: High levels of B2M were associated with an increased risk of ischemic stroke among women.
Feedback on Trait or Action Impacts on Caudate and Paracingulum Activity

There is a general conception that positive associations to one’s trait, e.g. ‘I’m clever’, are beneficial for cognitive performance. Scientific evidence shows that this is a simplification. In this functional magnetic resonance imaging (fMRI) study we used written trial-based trait feedback ‘you are clever’, or task feedback ‘your choice was correct’, on each correct response of a rule-switching task, to investigate how the character of positive self-associations influences performance outcome. Twenty participants took part in this crossover design study. We found that trait feedback was less beneficial for motivation and performance improvement, and resulting in enhanced neural activation on more difficult bivalent rule trials. This indicates that the task was treated as more complex in this condition. For example, ‘you are clever’ feedback led to enhanced activation in anterior caudate nucleus, an area known to process uncertainty. We further observed that activation in anterior paracingulate cortex was sensitive to whether self-reflection was imposed by external feedback or generated from internal processes, where the latter activation correlated positively with performance when following after task feedback. Our results illustrate how feedback can evoke self-reflections that either help or hinder motivation and performance, most likely by impacting on processes of uncertainty. The results support social psychological models stipulating that trait focus take resources away from task focus.
Neural correlates of stress-induced and cue-induced drug craving: influences of sex and cocaine dependence.

OBJECTIVE Although stress and drug cue exposure each increase drug craving and contribute to relapse in cocaine dependence, no previous research has directly examined the neural correlates of stress-induced and drug cue-induced craving in cocaine-dependent women and men relative to comparison subjects. METHOD Functional MRI was used to assess responses to individualized scripts for stress, drug/alcohol cue and neutral-relaxing-imagery conditions in 30 abstinent cocaine-dependent individuals (16 women, 14 men) and 36 healthy recreational-drinking comparison subjects (18 women, 18 men). RESULTS Significant three-way interactions between diagnostic group, sex, and script condition were observed in multiple brain regions including the striatum, insula, and anterior and posterior cingulate. Within women, group-by-condition interactions were observed involving these regions and were attributable to relatively increased regional activations in cocaine-dependent women during the stress and, to a lesser extent, neutral-relaxing conditions. Within men, group main effects were observed involving these same regions, with cocaine-dependent men demonstrating relatively increased activation across conditions, with the main contributions from the drug and neutral-relaxing conditions. In men and women, subjective drug-induced craving measures correlated positively with corticostriatal-limbic activations. CONCLUSIONS In cocaine dependence, corticostriatal-limbic hyperactivity appears to be linked to stress cues in women, drug cues in men, and neutral-relaxing conditions in both. These findings suggest that sex should be taken into account in the selection of therapies in the treatment of addiction, particularly those targeting stress reduction.
A Serenitatis origin for the Imbrian grooves and South Pole‐Aitken thorium anomaly

The northwest corner of the Moon's South Pole-Aitken (SPA) basin contains a high abundance of thorium and a unique Imbrian aged geomorphologic unit that consists of “grooves and mounds” (referred to here as the Imbrian grooves). Because the location of these features are almost antipodal to the Imbrium basin, where high-thorium ejecta and seismic energy are expected to have converged, an Imbrium origin for these units has long seemed certain. By modeling the deposition of impact ejecta on the Moon, we have investigated whether the convergence of Imbrium's ejecta at its antipode could be the origin of both the Imbrian grooves and SPA thorium anomaly. As a result of the Moon's rotation, our results show that ejecta from this basin should converge more than 12° west of its antipode. Both the Imbrian grooves and thorium anomaly within SPA, however, reside slightly to the east of Imbrium's antipode. In an attempt to reconcile this disparity, the effects of a putative oblique Imbrium impact have been qualitatively investigated. While this model can distribute ejecta in the general vicinity of the Imbrian grooves, the planform of our modeled antipodal ejecta is distinctly different from that which is observed. As an alternative explanation for the origin of these features, we find that the modeled distribution of ejecta from an oblique Serenitatis impact is surprisingly similar to the planform of the Imbrian grooves, with the exception that it is offset directly to the east. This eastward offset is likely to be an artifact of our not being able to properly include the effects of the Moon's rotation in our oblique impact models. We conclude that the Imbrium grooves and SPA thorium anomaly are most consistent with having an origin from the convergence of ejecta antipodal to the Serenitatis basin. If this conclusion can be substantiated once quantitative ejecta scaling relations for oblique impacts are determined, then this implies that (1) the Serenitatis target contained a high abundance of thorium and (2) the convergence of seismic energy at the antipodes of either the Imbrium or Serenitatis basin was not sufficient to cause substantial surface modification. Extrapolating this result to Mercury suggests that the “hilly and lineated” terrain antipodal to the Caloris basin was formed by the convergence of ejecta, and not seismic waves.