Miracle-dz/UniFAR-FTUs huggingface dataset:
Object-Centric Auto-Encoders and Dummy Anomalies for Abnormal Event Detection in Video

Abnormal event detection in video is a challenging vision problem. Most existing approaches formulate abnormal event detection as an outlier detection task, due to the scarcity of anomalous data during training. Because of the lack of prior information regarding abnormal events, these methods are not fully-equipped to differentiate between normal and abnormal events. In this work, we formalize abnormal event detection as a one-versus-rest binary classification problem. Our contribution is two-fold. First, we introduce an unsupervised feature learning framework based on object-centric convolutional auto-encoders to encode both motion and appearance information. Second, we propose a supervised classification approach based on clustering the training samples into normality clusters. A one-versus-rest abnormal event classifier is then employed to separate each normality cluster from the rest. For the purpose of training the classifier, the other clusters act as dummy anomalies. During inference, an object is labeled as abnormal if the highest classification score assigned by the one-versus-rest classifiers is negative. Comprehensive experiments are performed on four benchmarks: Avenue, ShanghaiTech, UCSD and UMN. Our approach provides superior results on all four data sets. On the large-scale ShanghaiTech data set, our method provides an absolute gain of 8.4% in terms of frame-level AUC compared to the state-of-the-art method.
Can solid-phase assays replace immunofluorescence for ANA screening?

The paper by Pisetsky et al 1 has stimulated a timely and interesting debate on a focal point in the diagnosis of autoimmune rheumatic diseases, that is, the accuracy of the antinuclear antibody (ANA) test and the reliability of the results provided by this test. The data produced by Pisetsky et al once more demonstrate the poor standardisation of the ANA assay when performed by the indirect immunofluorescence (IIF) method and the enormous difference that exists between different ANA-IIF kits. However, issues are related to intermethods variability and to the intrinsic limitations of the IIF method. Whatever title is chosen, it entails either a relevant loss of diagnostic specificity or sensitivity. This raises the question of whether IIF on HEp-2 cell substrates should be still considered the gold standard for ANA detection as stated almost 10 years ago by the American College of Rheumatology (ACR). The reasons that led the ACR to take this position were related to the insufficient diagnostic sensitivity of emerging alternative methods to IIF. These alternative methods, which were then almost exclusively made up of immunoenzymatic assays (ELISA), were spreading in clinical laboratories as substitutes of the manual IIF method to overcome known IIF limitations and for their higher throughput. …
The Effect of Berberine on Polycystic Ovary Syndrome Patients with Insulin Resistance (PCOS-IR): A Meta-Analysis and Systematic Review

Purpose To evaluate the effect of berberine (BBR) on polycystic ovary syndrome (PCOS) patients with insulin resistance (IR). Methods PubMed (in English), Medline (in English), Embase (in English), CNKI (in Chinese), WanFang DATA (in Chinese), and VIP (in Chinese) were searched for randomized controlled trials in human beings with the search terms including “polycystic ovary syndrome /PCOS” and “berberine/BBR/Huang liansu (in Chinese)/ Xiao bojian (in Chinese)” till July 2018. Relevant indices were collected and analyzed by Stata 13.0. Results A total of 9 randomized controlled trials were included. Limited data demonstrated the results as follows: No significant difference was found between berberine (BBR) and metformin (MET) on alleviating insulin resistance, improving glycolipid metabolism, or reproductive endocrine condition. MET combined with BBR was not superior to MET alone, but cyproterone acetate (CPA) combined with BBR was superior to CPA alone in improving some of the reproductive endocrine indices. The combination of BBR and Chinese herbs also showed positive effect. However there are insufficient data to make any conclusions on the effect of BBR on PCOS-IR. Conclusion BBR showed a promising prospect in treating PCOS-IR. But its mechanisms are still unclear, and more properly designed, randomized, double-blind, placebo-controlled trials are needed to further confirm its effect and safety.
Bidirectional type checking for relational properties

Relational type systems have been designed for several applications including information flow, differential privacy, and cost analysis. In order to achieve the best results, these systems often use relational refinements and relational effects to maximally exploit the similarity in the structure of the two programs being compared. Relational type systems are appealing for relational properties because they deliver simpler and more precise verification than what could be derived from typing the two programs separately. However, relational type systems do not yet achieve the practical appeal of their non-relational counterpart, in part because of the lack of a general foundation for implementing them. In this paper, we take a step in this direction by developing bidirectional relational type checking for systems with relational refinements and effects. Our approach achieves the benefits of bidirectional type checking, in a relational setting. In particular, it significantly reduces the need for typing annotations through the combination of type checking and type inference. In order to highlight the foundational nature of our approach, we develop bidirectional versions of several relational type systems which incrementally combine many different components needed for expressive relational analysis.
Deciphering global gene expression and regulation strategy in Escherichia coli during carbon limitation

Despite decades of studies meant to analyse the bacterial response to carbon limitation, we still miss a high‐resolution overview of the situation. All gene expression changes observed in such conditions cannot solely be accounted for by the global regulator Crp either free or bound to its effector, cyclic AMP. Here, for the first time, we evaluated the response of both CDS (protein‐coding sequence) and ncRNA (non‐coding RNA) genes to carbon limitation, revealed cellular functions of differentially expressed genes systematically, quantified the contribution of Crp‐cAMP and other factors to regulation and deciphered regulation strategies at a genomewide scale. Approximately one‐third of the differentially expressed genes we identified responded to Crp‐cAMP via its direct or indirect control, while the remaining genes were subject to growth rate‐dependent control or were controlled by other regulators, especially RpoS. Importantly, gene regulation mechanisms can be established by expression pattern studies. Here, we propose a comprehensive picture of how cells respond to carbon scarcity. The global regulation strategies thus exposed illustrate that the response of cell to carbon scarcity is not limited to maintaining sufficient carbon metabolism via cAMP signalling while the main response is to adjust metabolism to cope with a slow growth rate.
Predator stress-induced depression is associated with inhibition of hippocampal neurogenesis in adult male mice

Stress has been suggested to disturb the 5-hydroxytryptamine system and decrease neurogenesis, which contribute to the development of depression. Few studies have investigated the effect of predator stress, a type of psychological stress, on depression and hippocampal neurogenesis in adult mice; we therefore investigated this in the present study. A total of 35 adult male Kunming mice were allocated to a cat stress group, cat odor stress group, cat stress + fluoxetine group, cat odor stress + fluoxetine group, or a control group (no stress/treatment). After 12 days of cat stress or cat odor stress, behavioral correlates of depression were measured using the open field test, elevated plus maze test, and dark-avoidance test. The concentrations of hippocampal 5-hydroxytryptamine and 5-hydroxyindoleacetic acid were measured using high-performance liquid chromatography-electrochemical detection. Neurogenesis was also analyzed using a bromodeoxyuridine and doublecortin double-immunostaining method. Cat stress and cat odor stress induced depression-like behaviors; this effect was stronger in the cat stress model. Furthermore, compared with the control group, cat stress mice exhibited lower 5-hydroxytryptamine concentrations, higher 5-hydroxyindoleacetic acid concentrations, and significantly fewer bromodeoxyuridine+/doublecortin+-labeled cells in the dentate gyrus, which was indicative of less neurogenesis. The changes observed in the cat stress group were not seen in the cat stress + fluoxetine group, which suggests that the effects of predator stress on depression and neurogenesis were reversed by fluoxetine. Taken together, our results indicate that depression-like behaviors induced by predator stress are associated with the inhibition of hippocampal neurogenesis.
Influence of inflammatory disorders on pharmacokinetics of lisofylline in rats: implications for studies in humans

Abstract 1. Despite the number of favourable properties of lisofylline (LSF), clinical trials on this compound have not yielded the expected results yet. 2. The aims of this study were to evaluate the pharmacokinetics of LSF enantiomers in rats following intravenous, oral and subcutaneous administration of (±)-LSF and to assess the influence of experimental inflammatory disorders, such as multiple organ dysfunction syndrome and severe sepsis on LSF pharmacokinetics. 3. In addition, based on the results obtained an attempt was made to elucidate the possible reasons for the failure of LSF therapy in clinical trials carried out in patients with severe inflammatory disorders. 4. A subcutaneous route of (±)-LSF administration to rats is more favourable than an oral one due to a high bioavailability and a fast absorption of both LSF enantiomers. Pharmacokinetics of LSF in rats is significantly influenced by inflammatory diseases. Too low LSF serum levels might have been one of the reasons for clinical trial failures. A long-term i.v. infusion of LSF seems to be more effective compared to short-term multiple infusions that were used in clinical trials, as it may provide concentrations above IC50 for inhibition of both TNF-alpha release and cAMP degradation in serum for a longer period of time.
Hypoglycemic Interactive Effects of Ginger Eextract and Eendurance Training in Diabetic Rats

Article Type Original Research Authors Hosseini S.A. * PhD, Nemati J.1 PhD, Ranjbar M.2 MSc, Edalatmanesh M.A.3 PhD, Zar A.4 PhD How to cite this article Hosseini S A, Nemati J, Ranjbar M, Edalatmanesh M A, Zar A. Hypoglycemic Interactive Effects of Ginger Eextract and Eendurance Training in Diabetic Rats. Horizon of Medical Sciences. 2017;23(4) :325-330. Copyright© 2017 ASP Ins. This open-access article is published under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License which permits Share (copy and redistribute the material in any medium or format) and Adapt (remix, transform, and build upon the material) under the Attribution-NonCommercial terms. ٣٢٦ س ی لعد ی سح ی ن ی مه و ناراک ــــــــــــــــــــــ ـــــــــــ ــ ـــــــــــــــــــ ــــــــــــــ ـــــــــــــــ ــ ـــــــــــ ــ ـــــــــ ــــــــ ــــــــ ــــــــــــــــــــــــــــــــــــ ـــــــــــــــــــــــــــــــــــــــــــ لصف همان یملع یشهوژپ شناد قفا هرود ٢٣ هرامش ، ٤ ، زییاپ ١٣٩٦ یلماعت تارثا کیمسیلاگوپیه هراصع و لیجنز یتماقتسا نیرمت رب صخاش یدنق یاه شوم یاه
Simulating Liquids on Dynamically Warping Grids

We introduce dynamically warping grids for adaptive liquid simulation. Our primary contributions are a strategy for dynamically deforming regular grids over the course of a simulation and a method for efficiently utilizing these deforming grids for liquid simulation. Prior work has shown that unstructured grids are very effective for adaptive fluid simulations. However, unstructured grids often lead to complicated implementations and a poor cache hit rate due to inconsistent memory access. Regular grids, on the other hand, provide a fast, fixed memory access pattern and straightforward implementation. Our method combines the advantages of both: we leverage the simplicity of regular grids while still achieving practical and controllable spatial adaptivity. We demonstrate that our method enables adaptive simulations that are fast, flexible, and robust to null-space issues. At the same time, our method is simple to implement and takes advantage of existing highly-tuned algorithms.
Combined treatment with systemic resveratrol and resveratrol preconditioned mesenchymal stem cells, maximizes antifibrotic action in diabetic cardiomyopathy

Wnt/β‐catenin signaling pathway plays a crucial role in diabetic cardiomyopathy (DCM), thus we aimed at investigating the effect of one therapeutic approach with resveratrol (RSV) given systemically and combined treatment of RSV with mesenchymal stem cells (MSCs) that was either RSV‐preconditioned or not on Wnt/β‐catenin signaling pathway in streptozotocin‐induced DCM, and to evaluate effects of RSV preconditioning on MSCs therapeutic potential. The rats were divided into control (C, n = 8), diabetic (DM, n = 8), diabetic treated with systemic RSV (DM‐RSV, n = 8), diabetic treated with RSV and nonconditioned MSCs (DM‐RSV‐MSCs, n = 8), diabetic treated with RSV and RSV‐incubated with MSCs (DM‐RSV‐MSCc, n = 8) and diabetic treated with RSV‐conditioned MSCs (DM‐MSCc, n = 8). Echocardiography (Echo) showed significant improvement of cardiac functions in all groups treated with RSV either systemic or added in culture media. Data of ejection fraction (EF%) of DM‐RSV‐MSCc (81.50; interquartile range [IQR], 80.00–83.00) was comparable to both DM‐RSV‐MSCs (77.50; IQR, 71.50–79.00), and DM‐MSCc (71.50; IQR, 70.00–74.50). Histological examination of the left ventricles was performed for all groups. DM group revealed significant myocardial hypertrophy, apoptosis, interstitial fibrosis, and microvascular affection. All treated groups were associated, in variable degrees, with attenuation of cardiac hypertrophy and fibrosis, decreased area% for cardiac immunostaining of secreted frizzled‐related protein (sFRP2) and Wnt/β‐catenin and improvement of the microvasculature. In conclusion, MSCs pretreated with resveratrol for 7 days showed increased 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay, and combined use of RSV (systemically and in culture media) significantly could improve cardiac remodeling capacity of MSCs via attenuation of sFRP2‐mediated fibrosis and the downstream Wnt/β‐catenin pathway.
Clinical benefit of high resolution anorectal manometry for the evaluation of anal function after intersphincteric resection

Intersphincteric resection (ISR) is an advanced anus‐preserving operation for treating low rectal cancer while avoiding colostomy. High‐resolution anorectal manometry (HR‐ARM) allows objective and accurate evaluation of anal function. However, correlations between anal function after ISR and HR‐ARM parameters are unknown. The aim of the study was to evaluate HR‐ARM for objective evaluation of anal function after ISR.
Association between breast arterial calcifications found on mammography and coronary artery calcifications in asymptomatic Saudi women

BACKGROUND Currently, there are no data on the prevalence of breast arterial calcification (BAC) in Saudi women. Furthermore, there are no data on the relationship between BAC and coronary artery calcium score (CACS) as a coronary artery disease (CAD) risk factor in Saudi women who undergo mammography. OBJECTIVE Examine the role of BAC as a potential female-specific risk factor for CAD in Saudi women in order to investigate the relationship between BAC and CACS in women who undergo a screening mammography, and study the relationship between BAC and CAD risk factors, including age, diabetes mellitus, hypertension, chronic kidney disease (CKD), dyslipidemia, and family history of CAD. DESIGN Retrospective, medical records review. SETTING Single tertiary care center. PATIENTS AND METHODS The study cohort included women who had mammograms and a CACS scan, and for whom data on CAD risk stratification and CAD risk factors had been collected within one year of each other from 2014 to 2017. Women with CAD were excluded from the study. MAIN OUTCOME MEASURES Breast arterial calcification as a marker for coronary artery disease. SAMPLE SIZE 307 Saudi women. RESULTS BAC was found in 142 (46%) patients in the study population. BAC+ women were significantly older than the BAC− women (P=.001), and a strong association was found between BAC and CACS (P=.0001), diabetes (P=.0001), hypertension (P=.021), and CKD (P=.0031). However, no association was found between BAC and tobacco smoking, dyslipidemia, and family history of CAD. In addition, a strong correlation was found between CACS and the components of the BAC score (P<.001). Multivariate linear regression analysis revealed that age, CAC, and CKD are the only strong predictors of BAC. CONCLUSIONS The proportion of BAC in Saudi women is 46%, and there may be a strong association between BAC and CAC, age, hypertension, and CKD. A large-scale prospective research study is necessary to validate the role of BAC on screening mammography as a CAD risk stratification tool and before routine reporting of BAC on a mammography report. LIMITATIONS Because this was a retrospective study, patient selection bias cannot be excluded.
Evaluation of a high‐sensitivity cardiac troponin I assay compared to a first‐generation cardiac troponin I assay in Doberman Pinschers with and without dilated cardiomyopathy

Background Echocardiography and 24‐hour ECG are the gold standard tests to diagnose dilated cardiomyopathy (DCM) in Doberman Pinschers (DP), but myocardial damage might be detected earlier using a high‐sensitivity cardiac troponin I (hs‐cTnI) assay. Objective To evaluate and compare an hs‐cTnI assay (Advia Centaur TnI‐Ultra assay) with a conventional cTnI assay in DP with different stages of DCM and in healthy DP. Animals Three hundred forty‐five examinations from 162 DP with and 179 DP without DCM. Methods Prospective longitudinal study. Dogs were allocated into 6 groups based on echocardiographic and 24‐hour ECG criteria: (1) healthy group (179 dogs), (2) last‐normal group (29 dogs), which included dogs that were considered to be healthy at the time of their examination but were assigned to the last‐normal group retrospectively when DCM was diagnosed at their next examination within 1.5 years, (3) only arrhythmias (45 dogs, 119 examinations), (4) only echocardiographic changes (24 dogs, 61 examinations), (5) echocardiographic changes with ventricular premature complexes (41 dogs, 100 examinations), and (6) decompensated (23 dogs, 36 examinations). Hs‐cTnI and conventional cTnI concentration measurements were performed and compared. Results A cutoff value of hs‐cTnI concentration >0.113 ng/mL had a sensitivity of 81.2% and a specificity of 73.2% to identify the presence of DCM. The conventional cTnI assay showed a similar test performance, but the hs‐cTnI assay identified more dogs (21/29 dogs, 72%) in the last‐normal group compared to the conventional cTnI test (18/29 dogs, 62%). Conclusions and Clinical Importance The hs‐cTnI is an additional test with good potential to identify early DCM.
The most mentioned neurointervention articles in online media: a bibliometric analysis of the top 101 articles with the highest altmetric attention scores

Background and purpose Alternative metrics (altmetrics), based on mentions in online media, is a new tool that can help to identify the most influential articles to diverse public audiences. This article aimed to determine the 100 most mentioned articles in the field of neurointervention and to analyze their characteristics. Materials and methods We selected the 808 journals that were considered journals potentially publishing articles on neurointervention. We also selected articles using keywords. Using the Altmetric.com search tool, we identified the 101 most mentioned neurointervention articles based on the highest altmetric attention scores (AASs) within selected journals and articles. Each article was evaluated for several characteristics including AAS, number of citations, journal title, journal category, impact factor of the journal, year of publication, authorship, country, type of document, and topic. Results The AASs for the top 101 articles ranged from 1586 to 39. Stroke published the largest number of articles (19.8%) followed by the New England Journal of Medicine (17.8%). The majority of articles were published in multidisciplinary journals (38.6%), were published in 2017–2018 (43.6%), originated from the USA (54.5%), were original articles (66.3%), and dealt with intra-arterial thrombolysis or thrombectomy for acute ischemic stroke (58.4%). Tudor G Jovin was the most prolific author, authoring 18 of the most mentioned neurointervention articles Conclusions This study presents a detailed list of the 101 most mentioned neurointervention articles in online media, thus providing useful information on the dissemination of neurointervention research to the general public.
Na+/Ca2+ Exchanger 1 in Airway Smooth Muscle of Allergic Inflammation Mouse Model

Cytosolic free Ca2+ ([Ca2+]cyt) is essential for airway contraction, secretion and remodeling. [Ca2+]cyt homeostasis is controlled by several critical molecules, one of which is the Na+/Ca2+ exchanger 1 (NCX1) in the plasma membrane. Since little is currently known about NCX1 in the airway smooth muscle and its involvement in airway diseases, the present study was designed to investigate the expression and function of NCX1 in normal airway smooth muscle and its relevance to airway inflammation. Western blot analysis, tracheal smooth muscle contraction, and [Ca2+]cyt measurements were performed in mouse tracheal smooth muscle tissues and primary airway smooth muscle cell cultures. Additional studies were performed in a mouse model of allergic airway inflammation. Our data showed that NCX1 proteins were expressed in the human bronchial smooth muscle cells (HBSMCs), murine airway and whole lung. Carbachol raised [Ca2+]cyt in mouse tracheal smooth muscle cells and induced murine tracheal contraction, all of which were significantly attenuated by KB-R7943, a selective NCX inhibitor. Removal of extracellular Na+ increased [Ca2+]cyt in HBSMCs and mouse tracheal SMCs, which was dependent on extracellular Ca2+ and sensitive to KB-R7943. TNF-α treatment of HBSMCs significantly upregulated mRNA and protein expression of NCX1 and enhanced NCX activity. Finally, KB-R7943 abolished the airway hyperresponsiveness to methacholine in an ovalbumin-induced mouse model of allergic airway inflammation. Together, these findings indicate that NCX1 in airway smooth muscle may play an important role in the development of airway hyperresponsiveness, and downregulation or inhibition of NCX1 may serve as a potential therapeutic approach for asthma.