Miracle-dz/UniFAR-FTUs huggingface dataset:
The association between health conditions and cannabis use in patients with opioid use disorder receiving methadone maintenance treatment

Background Cannabis is the most commonly used substance among patients in methadone maintenance treatment (MMT) for opioid use disorder. Current treatment programmes neither screen nor manage cannabis use. The recent legalisation of cannabis in Canada incites consideration into how this may affect the current opioid crisis. Aims Investigate the health status of cannabis users in MMT. Method Patients were recruited from addiction clinics in Ontario, Canada. Regression analyses were used to assess the association between adverse health conditions and cannabis use. Further analyses were used to assess sex differences and heaviness of cannabis use. Results We included 672 patients (49.9% cannabis users). Cannabis users were more likely to consume alcohol (odds ratio 1.46, 95% CI 1.04–2.06, P = 0.029) and have anxiety disorders (odds ratio 1.75, 95% CI 1.02–3.02, P = 0.043), but were less likely to use heroin (odds ratio 0.45, 95% CI 0.24–0.86, P = 0.016). There was no association between cannabis use and pain (odds ratio 0.98, 95% CI 0.94–1.03, P = 0.463). A significant association was seen between alcohol and cannabis use in women (odds ratio 1.79, 95% CI 1.06–3.02, P = 0.028), and anxiety disorders and cannabis use in men (odds ratio 2.59, 95% CI 1.21–5.53, P = 0.014). Heaviness of cannabis use was not associated with health outcomes. Conclusions Our results suggest that cannabis use is common and associated with psychiatric comorbidities and substance use among patients in MMT, advocating for screening of cannabis use in this population. Declaration of interest None.
Comparisons of Rivaroxaban Following Different Dosage Criteria (ROCKET AF or J‐ROCKET AF Trials) in Asian Patients With Atrial Fibrillation

Background The ROCKET AF (Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation) evaluated rivaroxaban (20/15 mg/d) versus warfarin in patients with atrial fibrillation. A separate trial, J‐ROCKET AF (Japanese ROCKET AF), compared rivaroxaban (15/10 mg/d) and warfarin in Japanese patients with atrial fibrillation. Data about rivaroxaban following J‐ROCKET AF criteria compared with warfarin and ROCKET AF dosage were limited. Methods and Results This retrospective study used medical data from a multicenter healthcare provider in Taiwan that included 3162 patients taking rivaroxaban. Among 2320 patients with an estimated glomerular filtration rate (eGFR) ≥50 mL/min per 1.73 m2, 384 and 1936 patients followed the ROCKET AF (20 mg/d) and J‐ROCKET AF (15 mg/d) recommendation, respectively. Among 842 patients with an eGFR <50 mL/min per 1.73 m2, 422 and 420 patients followed the ROCKET AF (15 mg/d) and J‐ROCKET AF (10 mg/d) recommendation, respectively. A total of 2053 patients with atrial fibrillation receiving warfarin were identified. Rivaroxaban following either ROCKET AF or J‐ROCKET AF dosage criteria was associated with a comparable risk of thromboembolism but a lower risk of bleeding than warfarin. For patients with an eGFR ≥50 mL/min per 1.73 m2, risks of clinical events did not differ significantly between the 2 dosage criteria of rivaroxaban. For patients with an eGFR <50 mL/min per 1.73 m2, the ROCKET AF dosage was associated with a higher risk of major bleeding compared with the J‐ROCKET AF dosage (hazard ratio, 2.70; P=0.0445) without significant differences regarding the risk of ischemic events. Conclusions In Asian patients with atrial fibrillation, the J‐ROCKET AF dosage was as effective as the ROCKET AF dosage irrespective of renal function. The risk of major bleeding was lower with the J‐ROCKET AF dosage in patients with an eGFR <50 mL/min per 1.73 m2. Compared with warfarin, rivaroxaban following either dosage criteria was effective and even safer.
Complement C5a Induces Renal Injury in Diabetic Kidney Disease by Disrupting Mitochondrial Metabolic Agility

The sequelae of diabetes include microvascular complications such as diabetic kidney disease (DKD), which involves glucose-mediated renal injury associated with a disruption in mitochondrial metabolic agility, inflammation, and fibrosis. We explored the role of the innate immune complement component C5a, a potent mediator of inflammation, in the pathogenesis of DKD in clinical and experimental diabetes. Marked systemic elevation in C5a activity was demonstrated in patients with diabetes; conventional renoprotective agents did not therapeutically target this elevation. C5a and its receptor (C5aR1) were upregulated early in the disease process and prior to manifest kidney injury in several diverse rodent models of diabetes. Genetic deletion of C5aR1 in mice conferred protection against diabetes-induced renal injury. Transcriptomic profiling of kidney revealed diabetes-induced downregulation of pathways involved in mitochondrial fatty acid metabolism. Interrogation of the lipidomics signature revealed abnormal cardiolipin remodeling in diabetic kidneys, a cardinal sign of disrupted mitochondrial architecture and bioenergetics. In vivo delivery of an orally active inhibitor of C5aR1 (PMX53) reversed the phenotypic changes and normalized the renal mitochondrial fatty acid profile, cardiolipin remodeling, and citric acid cycle intermediates. In vitro exposure of human renal proximal tubular epithelial cells to C5a led to altered mitochondrial respiratory function and reactive oxygen species generation. These experiments provide evidence for a pivotal role of the C5a/C5aR1 axis in propagating renal injury in the development of DKD by disrupting mitochondrial agility, thereby establishing a new immunometabolic signaling pathway in DKD.
Particular issues of public health: vaccination

Public health measures vary greatly in their impact upon individuals. Some measures such as sanitation and water filtration are imposed upon whole populations without adverse effect. Medical interventions such as breast cancer screening are transiently uncomfortable but not invasive. Cervical smear tests are invasive but have no known lasting effects. Other public health measures such as water fluoridation may affect individual recipients, and the dilemma for those responsible for determination of public policy is the extent to which public health benefits justify individual risks. Vaccination is invasive, and involves the administration of pharmaceuticals to people who are well. The benefits of vaccines are prospective and to some extent speculative, and there is concern that they may occasionally have serious permanent adverse effects upon those who receive them.
Linear and nonlinear interrelations show fundamentally distinct network structure in preictal intracranial EEG of epilepsy patients

Resection of the seizure generating tissue can be highly beneficial in patients with drug‐resistant epilepsy. However, only about half of all patients undergoing surgery get permanently and completely seizure free. Investigating the dependences between intracranial EEG signals adds a multivariate perspective largely unavailable to visual EEG analysis, which is the current clinical practice. We examined linear and nonlinear interrelations between intracranial EEG signals regarding their spatial distribution and network characteristics. The analyzed signals were recorded immediately before clinical seizure onset in epilepsy patients who received a standardized electrode implantation targeting the mesiotemporal structures. The linear interrelation networks were predominantly locally connected and highly reproducible between patients. In contrast, the nonlinear networks had a clearly centralized structure, which was specific for the individual pathology. The nonlinear interrelations were overrepresented in the focal hemisphere and in patients with no or only rare seizures after surgery specifically in the resected tissue. Connections to the outside were predominantly nonlinear. In all patients without worthwhile improvement after resective treatment, tissue producing strong nonlinear interrelations was left untouched by surgery. Our findings indicate that linear and nonlinear interrelations play fundamentally different roles in preictal intracranial EEG. Moreover, they suggest nonlinear signal interrelations to be a marker of epileptogenic tissue and not a characteristic of the mesiotemporal structures. Our results corroborate the network‐based nature of epilepsy and suggest the application of network analysis to support the planning of resective epilepsy surgery.
Quantitative assessment of acetabular bone defects: A study of 50 computed tomography data sets

Objectives Acetabular bone defect quantification and classification is still challenging. The objectives of this study were to suggest and define parameters for the quantification of acetabular bone defects, to analyze 50 bone defects and to present the results and correlations between the defined parameters. Methods The analysis was based on CT-data of pelvises with acetabular bone defects and their reconstruction via a statistical shape model. Based on this data, bone volume loss and new bone formation were analyzed in four sectors (cranial roof, anterior column, posterior column, and medial wall). In addition, ovality of the acetabulum, lateral center-edge angle, implant migration, and presence of wall defects were analyzed and correlations between the different parameters were assessed. Results Bone volume loss was found in all sectors and was multidirectional in most cases. Highest relative bone volume loss was found in the medial wall with median and [25, 75]—percentile values of 72.8 [50.6, 95.0] %. Ovality, given as the length to width ratio of the acetabulum, was 1.3 [1.1, 1.4] with a maximum of 2.0, which indicated an oval shape of the defect acetabulum. Lateral center-edge angle was 30.4° [21.5°, 40.4°], which indicated a wide range of roof coverage in the defect acetabulum. Total implant migration was 25.3 [14.8, 32.7] mm, whereby cranial was the most common direction. 49/50 cases showed a wall defect in at least one sector. It was observed that implant migration in cranial direction was associated with relative bone volume loss in cranial roof (R = 0.74) and ovality (R = 0.67). Conclusion Within this study, 50 pelvises with acetabular bone defects were successfully analyzed using six parameters. This could provide the basis for a novel classification concept which would represent a quantitative, objective, unambiguous, and reproducible classification approach for acetabular bone defects.
Effect of thiourea-modified biochar on adsorption and fractionation of cadmium and lead in contaminated acidic soil

Abstract Biochar was obtained through pyrolysis of carrot pulp (CP) and then further modified with thiourea (CH4N2S). We investigated the effect of carrot pulp biochar (CPB) and modified CPB (MCPB) for adsorption and chemical fractionation of cadmium (Cd) and lead (Pb) in contaminated acidic soil. Application of modified biochar significantly (p < 0.05) increased the pH, soil organic carbon (SOC), and cation exchange capacity (CEC) of the soil, especially at the 8% application rate. The adsorption equilibrium data showed that the adsorption behavior of Cd and Pb could be described more reasonably by the pseudo-second-order kinetic model and the Langmuir isotherm model more accurately fitted the experimental data than Freundlich and Temkin isotherm models. The maximum adsorption capacity of soil treated with MCPB at the 8% application rate for Cd and Pb were 4122.7 and 5219.6 mg kg−1, respectively. Sequential chemical extractions revealed that incorporation soil with MCPB induced the transformation of the acid-soluble fraction of Cd to oxidizable and residual fractions, and the acid-soluble fraction of Pb to reducible, oxidizable, and residual fractions. The results demonstrated that the application of MCPB could effectively immobilize Cd and Pb, thereby reducing their mobility in contaminated acidic soil.
Prefrontal Regulation of Threat-Elicited Behaviors: A Pathway to Translation.

Regions of the prefrontal and cingulate cortices play important roles in the regulation of behaviors elicited by threat. Dissecting out their differential involvement will greatly increase our understanding of the varied etiology of symptoms of anxiety. I review evidence for altered activity within the major divisions of the prefrontal cortex, including orbitofrontal, ventrolateral, dorsolateral, and ventromedial sectors, along with the anterior cingulate cortex in patients with clinical anxiety. This review is integrated with a discussion of current knowledge about the causal role of these different prefrontal and cingulate regions in threat-elicited behaviors from experimental studies in rodents and monkeys. I highlight commonalities and inconsistencies between species and discuss the current state of our translational success in relating findings across species. Finally, I identify key issues that, if addressed, may improve that success in the future. Expected final online publication date for the Annual Review of Psychology, Volume 71 is January 4, 2020. Please see http://www.annualreviews. org/page/journal/pubdates for revised estimates.
Curcumin activates the Nrf2 pathway and induces cellular protection against oxidative injury.

Curcumin is a naturally occurring polyphenol which is isolated from the rhizome of Curcuma longa (turmeric). This medicinal compound has different biological activities including antioxidant, antibacterial, antineoplastic, and anti-inflammation. It has also therapeutic effects for cancer, neurodegenerative disorders, renal disorders, and diabetes mellitus. Curcumin is safe and well-tolerated at high concentrations without making toxicity. In the present review, we demonstrated curcumin affects the Nrf2 signaling pathway to exert its therapeutic and biological activities.
Hair Depigmentation and Hair Loss in Advanced Melanoma Treated with Combined Immunotherapy and Targeted Therapy

Journal Compilation © 2020 Acta Dermato-Venereologica. doi: 10.2340/00015555-3355 Immune checkpoint inhibitors (ICIs) and kinase inhibitors (BRAF and MEK inhibitors) have improved clinical outcomes in patients with advanced BRAFV600 mutant melanoma. Preliminary results from ongoing, phase III clinical trials of combined ICIs and kinase inhibitors have shown a manageable safety profile with promising efficacy. However, unbridled activation of the immune system may be associated with a wide spectrum of autoimmune or inflammatory side-effects. We describe here a case of a 62-year-old woman with stage IIID melanoma, treated with anti-PD1, BRAF and MEK inhibitors, which resulted in proximal hair depigmentation of the scalp and patchy hair loss, with complete response (CR) of the disease. It can be hypothesized, that this case represents a clinical example of cross T-cell reactivity against shared antigens between tumour cells and melanocytes on previously protected sites on the hair follicle, which may indicate an anti-tumour efficacy in patients treated with ICI-based therapy.
Sonological evaluation of abdominal organs in sickle cell crisis in Western Orissa

OBJECTIVE : Sickle cell disease (SCD), being prevalent in the western belt of Orissa, the following study was undertaken to evaluate the various spectrum of abdominal sonographic findings involving the liver, spleen, gall bladder and kidneys. MATERIALS AND METHODS : The study included fifty patients of SCD presented with acute symptoms of sickle cell crisis. RESULTS : The most frequent US findings in the study were: hepatomegaly (72 percent), splenomegaly (64 percent) and cholelithiasis (22 percent). 22 percent of patients presented with splenic infarction, 10 percent patients showed splenic calcification. Increased bilateral renal echogenicity was observed in 16 percent of patients. CONCLUSIONS : To conclude ultrasonography is a readily accessible and non invasive method for the evaluation of different abdominal organs.
Relationships between trait emotion dysregulation and emotional experiences in daily life: an experience sampling study

ABSTRACT Few studies have examined how trait emotion dysregulation relates to momentary affective experiences and the emotion regulation (ER) strategies people use in daily life. In the current study, 112 college students completed a trait measure of emotion dysregulation and completed experience sampling and end-of-day surveys over a two- to three-week period, asking about their emotional experiences and ER strategy use. Participants completed a total of 3798 experience sampling (in-the-moment) and 995 nightly diary surveys. We examined the top 40% of each participant’s reported instances of negative affect (to capture times when emotions more likely need regulation). Results indicated that a higher level of trait emotion dysregulation was associated with the following in-the-moment responses: (a) higher level of negative affect; (b) greater desire to change emotions; (c) more attempts to regulate emotion; (d) higher relative endorsements of avoidant (e.g. thought suppression) versus engagement (e.g. acceptance) ER strategy use; and (e) lower perceived effectiveness of ER. Further, individuals with a higher (vs. lower) level of trait emotion dysregulation were less able to identify emotions over the course of the day. Findings demonstrate how trait emotion dysregulation may predict emotional experiences and ER in daily life.
Thermal Transport in a 2D Nanophononic Solid: Role of bi-Phasic Materials Properties on Acoustic Attenuation and Thermal Diffusivity

Nanophononic materials have recently arisen as a promising way for controlling heat transport, mirroring the results in macroscopic phononic materials for sound transmission, filtering and attenuation applications. Here we present a Finite Element numerical simulation of the transient propagation of an acoustic Wave-Packet in a 2D nanophononic material, which allows to identify the effect of the nanostructuration on the acoustic attenuation length and thus on the transport regime for the vibrational energy. Assuming elastic behavior in the matrix and in the inclusions, we find that the rigidity contrast between them not only tunes the apparent attenuation length of the wave packet along its main trajectory, but gives rise to different behaviours, from weak to strong scattering, and waves pinning. As a consequence, different energy transport regimes can be identified in the three-parameter space of the excitation frequency, inclusions size and rigidity contrast, leading to the identification of a combination of parameters allowing for the shortest attenuation distance. These results could have applications both in the field of acoustic insulation, and for the control of heat transfer.
Evaluating the Far-Infrared Radiation Bioeffects on Micro Vascular Dysfunction, Nervous System, and Plantar Pressure in Diabetes Mellitus

The most frequent clinical complication is diabetes. Diabetes is characterized by elevated blood glucose levels resulting in sensory nerve damage or lesions. Diabetic foot wounds are often slow to heal and require medical attention and monitoring. This study evaluates the effect of far-infrared radiation on the microcirculation and plantar pressure in the diabetic foot. Ten diabetics and 4 nondiabetics were recruited in this study. The diabetic group was examined before and after the intervention in each month for 3 consecutive months. Four nondiabetic groups were also measured before and after the intervention for 2 weeks in each month. The surface temperature and blood flow in the diabetic foot was significantly improved (temperature: 32.1 ± 2.3°C vs 33.5 ± 2.2°C, P < .05; blood flow image: 118.3 ± 58.1 PU [perfusion unit] vs 50.4 ± 4.3 PU, P < .05). The sympathetic nerve activity index LF also increased from 40.8 ± 18.6% to 61.8 ± 13.5% (P = .07) in the second month. Plantar pressure tended to increase in the third month. This might indicate that far-infrared radiation could affect the mechanical properties of the plantar foot soft tissue. These results indicated that the effects of far-infrared radiation would improve blood circulation and change the soft tissue properties in the diabetic foot.
Evaluation of Chemical Composition of Two Linseed Varieties as Sources of Health-Beneficial Substances

Linseed (Linum usitatissimum L.) is becoming more and more important in the health food market as a functional food, since its seeds and oil represent a rich source of bioactive compounds. Its chemical composition is strongly correlated with, and dependent on, genetic characteristics. The aim of this study was to evaluate the variation in seed yield, oil content, fatty acid composition and secondary metabolite profiles between a low-linolenic linseed variety, belonging to the Solin-type group (Solal), and a high-linolenic traditional one (Bethune), cultivated, both as spring crops, in open field conditions of Central Italy. The achieved results pointed out the different behavior of the two varieties in terms of growth cycle, oil content, and some important yield components, such as capsule number per plant and thousand seed weight. There were also significant differences in seed composition regarding total phenols, total flavonoids, antioxidant activities as well as in carotenoid, tocopherol, and tocotrienol profiles between the two varieties. In particular, Solal was characterized by the greatest contents of oil, phenols, flavonoids, α- and δ- tocotrienol, together with the highest antioxidant activity. Bethune, on the contrary, showed the highest amounts of carotenoids (lutein and β-carotene). These results indicate a clear effect of the genetic characteristics on the biosynthesis of these secondary metabolites and, consequently, on the related antioxidant activity. Our findings suggest that the mutation process, responsible for the selection of the low-linolenic cultivar, is able to modify the biosynthetic pathways of carotenoids and phenolics.
Risk Factors for Recurrent Community-associated Clostridiodes Difficile Infection in Children.

BACKGROUND Recurrence of community-associated (CA) Clostridiodes difficile infection (CDI) approaches 30%. Studies on risk factors and treatment of choice for pediatric CA-CDI are scarce with variable recommendations. METHODS This was a retrospective cohort study of the electronic health records of children 1-17 years with stool specimens sent for C. difficile at Kaiser Permanente Northern California from January 01, 2012 to December 31, 2016. Children with (1) CA disease, (2) confirmatory C. difficile laboratory testing with no other identified causes of diarrhea and (3) clinical symptoms consistent with CDI were defined as cases. Recurrent CA-CDI was defined using the above-described case criteria and onset of diarrhea within 8 weeks of primary CA-CDI. RESULTS Of the 7350 children with stool samples sent for C. difficile testing, 408 had primary CA-CDI. Forty-five (11%) experienced a recurrence. Using multivariable logistic regression, inflammatory bowel disease [odds ratio (OR) 7.5; 95% confidence interval (CI): 2.6-21.1] and cancer (OR 6.3; 95% CI: 1.6-24.1) diagnoses were risk factors for recurrent disease. Compared with children of Caucasian race, those with multi/other/unknown race had an OR of 3.03 (95% CI: 1.04-8.82) of recurrence. There was no statistically significant difference in the type or duration of therapy as a predictor for recurrent CA CDI. Six percent of children who received metronidazole were switched to vancomycin due to subjective metronidazole allergy or intolerance or metronidazole treatment failure. CONCLUSIONS Recurrent CA-CDI in children in our population is less common than previously reported. This study supports first-line treatment with the standard, short course metronidazole in most cases of primary CA-CDI.