Miracle-dz/UniFAR-FTUs huggingface dataset:
Osteochondritis Dissecans of the Patellofemoral Joint

Osteochondritis dissecans of the patellofemoral joint is an uncommon condition that may be the cause of anterior knee pain or crepitus. We present the clinical features of 37 patients with osteochondritis dissecans lesions of the patellofemoral joint (24 on the patella, 13 on the trochlear groove), including two patients with medial trochlear groove lesions, which have not, to our knowledge, been previously reported. The osteochondral lesions involved the convex articular surfaces. The median age of patients when first examined was 15 years, and 54% of patients had open epiphyses. These lesions were more common in male patients than in female patients (four-to-one ratio). Osteochondritis dissecans of the patellofemoral joint can be overlooked unless quality radiographs are viewed with care and, at arthroscopy, both the patella and trochlear groove are assessed. Treatment depends on the symptoms, site, and nature of the lesion and the patient's age. Nonoperative management includes patellar taping and vastus medialis obliquus muscle exercises. Operative intervention is indicated for patients with mechanical symptoms and includes arthroscopy, consisting of chondroplasty and removal of loose bodies, and lateral retinacular release. In this study treatment generally improved the symptoms, but patients with articular cartilage loss had persistent patellofemoral crepitus and discomfort.
Changes in the Angular Vestibulo‐Ocular Reflex after a Single Dose of Intratympanic Gentamicin for Ménière's Disease

Meniere’s disease is an inner ear disorder that causes episodic vertigo, hearing loss, tinnitus, and fullness in the ear. The clinical disorder has been associated with hydrops, a distension of the endolymphatic fluid compartment of the inner ear. The majority of patients can successfully control their attacks of vertigo with diuretics and restriction of sodium intake. However, about 30% of patients with Meniere’s disease have intractable vertigo that does not respond to these measures. The intratympanic (middle ear) injection of gentamicin is now an alternative to ablative surgery for these patients. Gentamicin is an aminoglycoside antibiotic that is toxic to the hair cells of the inner ear, with somewhat greater vestibular toxicity than cochlear toxicity. We have treated 102 patients with unilateral Meniere’s disease with intratympanic gentamicin. Attacks of vertigo have been completely controlled in 83%, and substantially controlled (>60% reduction in frequency) in 12%. Profound hearing loss occurred as a result of treatment in only 2%, and the overall rate at which hearing declined after treatment (19%) did not differ from the expected decline in hearing with active Meniere’s disease. Recent evidence suggests that a single dose of intratympanic gentamicin can be effective in controlling vertigo in Meniere’s disease. 1 This study was undertaken to determine the effect of a single intratympanic injection of gentamicin on the function of the human angular vestibulo-ocular reflex (AVOR) in subjects with Meniere’s disease.
stroke in persons with type 2 diabetes mellitus : a systematic review and The effect of intensive glucose control on all-cause and cardiovascular mortality , myocardial

We performed a meta-analysis of studies evaluating the effect of intensive glucose control on major adverse cardiovascular events in patients with type 2 diabetes from 1990 to 2009. A search of the published literature and the Cochran Central Register for Controlled Trials was performed using pre-specified inclusion criteria consisting of randomised controlled trials evaluating intensive glycaemic control and reporting the individual endpoints of all-cause mortality, nonfatal myocardial infarction, and non-fatal stroke. Incident rate ratios for these endpoints were calculated using standard meta-analytic techniques of pooled data from eligible trials. Six reports from four randomised trials including 27,544 patients met the pre-specified inclusion criteria. Mean follow-up was 5.4 years; haemoglobin A1C at study end was 6.6% vs. 7.4% in patients randomised to intensive compared with conventional glucose control. Intensive glucose control did not affect the incident rate ratio for all-cause mortality (1.01, 95% confidence interval 0.86–1.18, p=0.54) or stroke (1.02, 95% confidence interval 0.88–1.20, p=0.62). However, there was a statistically significant 14% reduction in nonfatal myocardial infarction in patients randomised to intensive glucose control (0.86, 95% confidence interval 0.77–0.97, p=0.015). Although intensification of glucose control did not affect mortality or non-fatal stroke, the risk for non-fatal myocardial infarction was significantly reduced in patients with type 2 diabetes.
Behavioral traits predicting alcohol drinking in outbred rats: an investigation of anxiety, novelty seeking, and cognitive flexibility.

BACKGROUND Most adults in Western society consume alcohol regularly without negative consequences. For a small subpopulation, however, drinking can quickly progress to excessive and chronic intake. Given the dangers associated with alcohol abuse, it is critical to identify traits that may place an individual at risk for developing these behaviors. To that end, we used a rat model to determine whether anxiety-related behaviors, novelty seeking, or cognitive flexibility predict excessive alcohol drinking under both limited and continuous access conditions. METHODS Adult male rats were assessed in a series of behavioral tasks (elevated plus maze [EPM], locomotor activity, and discrimination/reversal learning in a Y-maze) followed by 6 weeks of daily, 1-hour access to alcohol in a free-choice, 2-bottle paradigm (10% alcohol vs. tap water). Next, subjects were given the opportunity to consume alcohol for 72 hours in drinking chambers that permit separate measures of each drinking bout. Half of the animals experienced a 2-week deprivation period between the limited and continuous access sessions. RESULTS Time spent on the open arms of the EPM, but not novelty seeking or discrimination/reversal learning, predicted alcohol consumption during limited, 1-h/d access sessions to alcohol. Anxiety-related behavior also predicted the escalation of intake when animals were given 72 hours of continuous access to alcohol. Bout size, but not frequency, was responsible for the increased consumption by high-anxiety subjects during this period. Finally, intake during limited access sessions predicted intake during continuous access, but only in subjects with low intake during limited access. CONCLUSIONS These findings confirm that preexisting anxiety-related behavior predicts alcohol intake under several schedules of alcohol access. Moreover, when access is unlimited, the high-anxiety-related group exhibited an increase in bout size, but not frequency, of drinking. In addition, we show that modest intake when alcohol is restricted may or may not progress to excessive intake when the drug is freely available.
Effect of Thickness on Structural and Electrical Properties of CuAlS2 Thin Films Grown by Two Stage Vacuum Thermal Evaporation Technique

: This work studies the effect of thickness on structural and electrical properties of CuAlS2 thin films grown by two stage vacuum thermal evaporation technique. CuAlS2 thin films of thicknesses 50nm, 100nm and 200nm were deposited on suitably cleaned corning 7059 glass substrate at room temperature (RT). In the first stage Cu-Al precursors were grown at room temperature by thermal evaporation and in the second stage Cu-Al precursors were converted to CuAlS2 thin films by sulfurisation under sulfur atmosphere at the temperature of 673K. The structural properties of the films were examined by X-ray diffraction (XRD) technique while electrical properties of the specimens were studied using four point probe method. The XRD studies revealed that the films are of crystalline in nature having tetragonal structure. The variations of the micro-structural parameters, such as crystallite size (D), dislocation density ( ), and micro-strain ( ), with film thickness were investigated. The results showed that the crystallite sizes increase as the thickness of the film increases. The dislocation density and micro-strain decreases as the thickness increases. The resistivity (  ) of CuAlS2 film is found to decrease with increase in film thickness, which is related to the increase of carrier concentration with film thickness. Thus thicker films exhibit the lowest resistivity and high carrier concentration, implying these are the most conductive films. Low electrical resistivity and high carrier concentration are widely used as the essential components in various optoelectronic devices such as light-emitting diode and photovoltaic cells.
Demonstration of “naturally occurring mitochondrial antibodies” in family members of patients with primary biliary cirrhosis

Sera from 81 healthy family members (including husbands) of 13 patients with primary biliary cirrhosis were tested by Western blotting against the antigen fractions M9 and M2 derived respectively from rat liver and beef heart mitochondria. Fifty‐eight (70%) were positive and recognized four major (molecular weights 98 kD, 65 kD, 61 kD, 58 kD) and eight minor determinants (85 kD, 81 kD, 78 kD, 54 kD, 48 kD, 45 kD, 40 kD, 30 kD) labeled α‐my. Each of the 58 sera recognized at least one of the four major polypeptides. In contrast, only 6% of 80 primary biliary cirrhosis patients had antibodies against one of these epitopes. Sera from 25 patients with different infectious disorders previously shown to react with submitochondrial particles by enzyme‐linked immunosorbent assay also recognized at least one of the four major determinants.
CONTINUING CHALLENGES IN THE MANAGEMENT OF RETINOBLASTOMA WITH CHEMOTHERAPY

Summary: The management of retinoblastoma has gradually changed over the past 10 years. Over 95% of children with retinoblastoma in the United States are cured with modern techniques. The challenge remains, however, in maintaining the eye and vision. There is a trend away from enucleation and external beam radiotherapy toward focal conservative treatments involving primary chemoreduction in conjunction with thermotherapy and cryotherapy. This is related to earlier detection of the disease, recognition of more effective chemotherapeutic agents, more focused local treatment modalities, and, most importantly, knowledge of the long-term risks of external beam radiotherapy. Enucleation is still preferable for retinoblastoma that fills most of the eye, especially when the disease is unilateral or when there is concern for tumor invasion into the optic nerve, choroid, or orbit. The orbital integrated implant is placed after enucleation and provides acceptable prosthesis motility and appearance. External beam radiotherapy is still vital for treating advanced retinoblastoma, especially when there is diffuse vitreous or subretinal seeding after failure of other methods and preservation of vision is a priority. The most important recent advance in the management of retinoblastoma is the use of intravenous chemotherapy for tumor reduction, a technique of neoadjuvant chemotherapy termed “chemoreduction. ” This is followed by tumor consolidation with focal measures such as thermotherapy, cryotherapy, and plaque radiotherapy. This strategy provides reduced tumor volume and often permits consolidation with methods other than radiotherapy. It appears that vision can be preserved in some cases with these methods, avoiding some of the local complications like radiation cataract or macular edema that have been found with radiotherapy techniques. External beam radiotherapy and enucleation can now be avoided in most cases of Reese–Ellsworth groups I (minimal disease) through IV (moderate disease) retinoblastoma. The most advanced stage of retinoblastoma, Reese–Ellsworth group V, continues to provide the greatest difficulty for management, and external beam radiotherapy and enucleation are often employed in addition to chemoreduction to save the child’s life. A collaborative prospective study in North America is currently under way to further study the benefits and risks of chemoreduction for minimal, moderate, and advanced retinoblastoma.
Internalizing disorders in child psychiatric patients across time: Diagnoses and causes for referral

With regard to internalizing disorders we wanted to describe: 1) a possible change in diagnoses over time; 2) a possible corresponding change in causes for referral; 3) correspondence of hospital diagnosis with causes for referral. For 70 randomly selected records/year (n=560), referral papers were examined and compared with register-data on all 8–13-year-old children examined in the study period (1995–2002). The hospital-based frequency increased for depressive disorders and obsessive–compulsive disorder (OCD) and decreased for anxiety disorders. A corresponding increase occurred for depressive and OCD symptoms as cause for referral. Agreement between referral causes and subsequent clinical diagnoses was modest. In most cases (68%) referred for internalizing symptoms, a clinical diagnosis within the internalizing spectrum was given. The increase in the diagnoses of depressive disorder and OCD seems partly due to an increase in patients referred for these disorders. Referrers identify internalizing disorders reliably but child psychiatric examination leads to more precise diagnoses.
Recursos tecnológicos en contextos educativos

En esta obra se pretende ofrecer una vision general de los fundamentos pedagogicos para una adecuada integracion de los recursos tecnologicos en educacion con temas como: modelos didactico-tecnologicos para la innovacion, competencias TIC en diferentes contextos, estrategias didacticas con TIC, el educador social como investigador en la practica y los entornos personales de aprendizaje. Asi mismo se abordan distintos recursos TIC desde una perspectiva descriptiva y aplicativa: recursos educativos en abierto, elearning, web 2.0, redes sociales, videojuegos y recursos moviles. Como material complementario se incluyen experiencias tecnopedagogicas que ilustran la aplicacion de las TIC en distintos contxtos educativos.
Tales of Time, Terms, and Patient Information-Seeking Behavior—An Exploratory Qualitative Study

This study explores patients' and physicians' perceptions of the use of medical terminology in patient–physician communication. Perceptions of time emerge as an overarching theme and the relationships between perceived time pressures and medical terms are analyzed. Data for this qualitative exploratory study were collected in 28 semistructured interviews with native and nonnative English-speaking physicians and patients. Interviews were recorded, transcribed and analyzed in NVivo 8, applying principles from grounded theory. Participants commonly perceived time pressures on consultations. Findings indicate that together, perceived time pressures and medical terminology influence patient participation and the development of rapport in medical encounters. Patient information-seeking behavior was reported to be lower in short, terminology-dense consultations and increased in longer, terminology-sparse consultations. Data suggest that monitoring the use of medical terms in combination with taking time to provide appropriate explanations can function as a partnership-building strategy. Physicians who adopt this strategy could foster better patient–physician relationships and facilitate increased patient information-seeking behavior.
Changes in nutritional status and body composition during enzyme replacement therapy in adult‐onset type II glycogenosis

Background: In adult glycogen storage disease type II (GSDII), a single‐gene mutation causes reduction of the lysosomal enzyme acid alpha‐glucosidse. This produces a chronic proximal myopathy with respiratory involvement. Enzyme replacement treatment (ERT) has recently become available and is expected to improve muscle strength. This should result in increased lean body mass. In this study we evaluate body composition and nutritional status in GSDII, and assess whether these parameters changed during treatment.
Molecular diagnosis of ewing family tumors: too many fusions... ?

In the field of sarcoma molecular diagnosis, the "test" most frequently requested is for the gene fusions generated by the chromosomal translocations in Ewing family tumors (EFTs). Of note, this test is perhaps the most complicated of all of the molecular assays in the sarcoma diagnostic toolbox. Starting with the frequent 11;22 translocation involving the EWS gene on chromosome 22 and the FLI1 gene on chromosome 11, the chromosome breakpoints are spread among four introns in the EWS gene and six introns in the FLI1 gene to give a large number of possible EWS-FLI1 fusion products.1 The size of the fusion transcripts can vary over a 700-bp range, thereby necessitating cautious investigation of a large range of product sizes in diagnostic reverse transcription-polymerase chain reaction (RT-PCR) assays. To increase the complexity further, a relatively frequent variant 21;22 chromosomal translocation generates a fusion of EWS to ERG, which encodes an ETS domain-containing transcription factor highly related to FLI1 with a comparable distribution of chromosomal breakpoints.1 Next, as described in the article by Wang and associates in this issue of The Journal of Molecular Diagnostics,2 the complexity continues to rise as there are three additional translocations [t(2;22), t(7;22), and t(17;22)] that juxtapose EWS to genes, encoding three additional members of the ETS transcription factor family (FEV, ETV1, and E1AF, respectively) in small numbers of EFT cases. In addition to these rare variant fusions, there is also a second set of rare variants involving the FUS gene, which encodes an RNA-binding protein highly related to EWS. This second set includes a 16;21 translocation in which FUS is juxtaposed to ERG,3 which was found in a small group of cases and, as described by Ng and colleagues4 also in this issue of the JMD, a FUS-FEV fusion resulting from a novel 2;16 translocation found in a single case. Based on these collective findings, a definitive investigation of the gene fusions associated with EFT is, to put it simply, a daunting task.
iTrack: instrumented mobile electrooculography (EOG) eye-tracking in older adults and Parkinson’s disease

Detection of saccades (fast eye-movements) within raw mobile electrooculography (EOG) data involves complex algorithms which typically process data acquired during seated static tasks only. Processing of data during dynamic tasks such as walking is relatively rare and complex, particularly in older adults or people with Parkinson’s disease (PD). Development of algorithms that can be easily implemented to detect saccades is required. This study aimed to develop an algorithm for the detection and measurement of saccades in EOG data during static (sitting) and dynamic (walking) tasks, in older adults and PD. Eye-tracking via mobile EOG and infra-red (IR) eye-tracker (with video) was performed with a group of older adults (n = 10) and PD participants (n = 10) (⩾50 years). Horizontal saccades made between targets set 5°, 10° and 15° apart were first measured while seated. Horizontal saccades were then measured while a participant walked and executed a 40° turn left and right. The EOG algorithm was evaluated by comparing the number of correct saccade detections and agreement (ICC2,1) between output from visual inspection of eye-tracker videos and IR eye-tracker. The EOG algorithm detected 75–92% of saccades compared to video inspection and IR output during static testing, with fair to excellent agreement (ICC2,1 0.49–0.93). However, during walking EOG saccade detection reduced to 42–88% compared to video inspection or IR output, with poor to excellent (ICC2,1 0.13–0.88) agreement between methodologies. The algorithm was robust during seated testing but less so during walking, which was likely due to increased measurement and analysis error with a dynamic task. Future studies may consider a combination of EOG and IR for comprehensive measurement.
Glucocorticoid replacement therapy in patients with Addison’s disease

One hundred and fifty years ago, Thomas Addison published his classic paper on the ‘Constitutional and Local Effects of Disease of the Supra-renal Capsules’, in which he described 11 patients with the disorder that would come to bear his name. Adrenal insufficiency is a rare disease, but its prevalence is increasing. The most frequent causes of adrenal insufficiency in western countries are autoimmune adrenalitis, but other causes include, tuberculosis systemic fungal infections, AIDS, metastatic carcinoma and isolated glucocorticoid deficiency. It is clear that autoimmunity precedes overt Addison’s disease by years, as in many autoimmune endocrine disorders 1, 2, 3. Adrenocortical function is lost over a period of years as it progresses to overt Addison’s disease. This editorial discusses the controversial glucocorticoid replacement therapy in patients with Addison’s disease, and aims to provide a good review of literature and suggested guidelines for appropriate treatment of this disease.
Effects of coumestrol administration to pregnant and lactating mice on intestinal alkaline phosphatase activity

The present study was conducted to clarify the effects of coumestrol administration on Ca metabolism during pregnancy and in lactating mice. From 6.5 to 16.5 days post coitus (dpc), pregnant mice were administered coumestrol at 200 µg/kg body weight/day. The duodenum, jejunum and blood samples were obtained at 17.5 dpc or 10 days after parturition (dap). Coumestrol administration decreased alkaline phosphatase (ALP) activity and mRNA expression of IAP and estrogen responsive genes, c‐fos and vascular endothelial growth factor (VEGF), in the duodenum and jejunum of pre‐delivery mice. In lactating mice, the ALP activity and mRNA expression of IAP were not changed, although coumestrol administration decreased mRNA expression of c‐fos in the duodeum and VEGF in the jejunum. Coumestrol did not affect serum Ca and the expression of vitamin D receptor protein in the duodenum and jejunum. Thus, coumestrol administration during pregnancy may decrease the mRNA expression of IAP and the ALP activity in the intestine of the pre‐delivery mice through ERα, but coumestrol had little effect on intestinal ALP activity at 10 days after parturition. Copyright © 2010 John Wiley & Sons, Ltd.