Miracle-dz/UniFAR-FTUs huggingface dataset:
Therapies for bleomycin induced lung fibrosis through regulation of TGF‐β1 induced collagen gene expression

This review describes normal and abnormal wound healing, the latter characterized by excessive fibrosis and scarring, which for lung can result in morbidity and sometimes mortality. The cells, the extracellular matrix (ECM) proteins, and the growth factors regulating the synthesis, degradation, and deposition of the ECM proteins will be discussed. Therapeutics with particular emphasis given to gene therapies and their effects on specific signaling pathways are described. Bleomycin (BM), a potent antineoplastic antibiotic increases TGF‐β1 transcription, TGF‐β1 gene expression, and TGF‐β protein. Like TGF‐β1, BM acts through the same distal promoter cis‐element of the COL1A1 gene causing increased COL1 synthesis and lung fibrosis. Lung fibroblasts exist as subpopulations with one subset predominately responding to fibrogenic stimuli which could be a specific cell therapeutic target for the onset and development of pulmonary fibrosis. J. Cell. Physiol. 211: 585–589, 2007. © 2007 Wiley‐Liss, Inc.
Marbling Texture’s Effects on Beef Palatability 1

The objective of this study was to evaluate the effects of marbling texture on consumer and trained sensory panel ratings of beef strip loin steaks from 3 USDA quality grades. Beef strip loins (n = 117) were selected from 3 quality grades [Top Choice (Modest00 – Moderate100 marbling), Low Choice (Small00 – Small100 marbling), and Select (Slight00 – Slight100 marbling)] to equally represent three different marbling texture groups: fine, medium, and coarse, via visual appraisal. There were no quality grade × texture interactions (P > 0.05) for all of the traits evaluated. Consumers (n = 104) rated all marbling texture groups similar (P > 0.05) for tenderness, juiciness, flavor, and overall liking, as well as rated a similar (P > 0.05) percentage of samples from each marbling texture group acceptable for each palatability trait. Moreover, consumers indicated no preference (P > 0.05) among marbling texture groups for visual desirability or likelihood to purchase. However, trained sensory panelists rated coarse marbled steaks higher (P 0.05) among marbling texture groups for Warner-Bratzler shear force, slice shear force, and pressed juice percentage. Low Choice steaks were rated higher (P 0.05) to Top Choice. Results from this study indicate marbling texture had no impact on consumer evaluations of eating quality and only minimal effects on trained sensory panel palatability ratings and therefore provides no palatability-based evidence for the exclusion of coarse marbled carcasses from current and future branded beef programs.
Collection and incineration of particulate matters from the diesel engine by charged dielectric surface and dielectric barrier discharge

The flue gas emission from combustion systems such as coal or oil fuel boiler, incinerator or diesel engine contains particulate matters composed mainly of carbon. Since these particles are proved to have an impact of human respiratory systems, they must be removed from the flue gas and treated effectively. However, in general their low electrical conductivity prevents electrostatic precipitation from collection with high efficiencies because of the re-entrainment of the collected particles. In this work, dielectric surface charged in advance was used to collect diesel particles and subsequent dielectric barrier discharge was tested to incinerate them collected on the surface to create another electrostatic collection system more effective than conventional ones.
Corporate Social Responsibility and Financial Performance: An Examination of the Dow Jones Sustainability North American Index

of Thesis Corporate Social Responsibility and Financial Performance: An Examination of the Dow Jones Sustainability North American Index This thesis explores the topic of corporate social responsibility (CSR) and the relationship between CSR and corporate profitability. This thesis includes a literature review which traces the history of CSR from 1920s through current theoretical positions. The thesis then examines the relationship between financial gain and CSR as defined by the sustainability parameters set by the Dow Jones Sustainability Index North America. Results from analysis performed show that corporations which practice CSR may benefit from increased stability compared to other index performance criteria, but improved financial performance as measured by stock price is inconclusive. _________________________________ Elizabeth A. Fides
The Color of Support: The Effect of Sponsor–Team Visual Congruence on Sponsorship Performance

Brand sponsorship connects brands with large, passionate audiences. The sponsorship literature emphasizes the importance of brand sponsor–team congruence; however, prior research has largely focused on the relevance of the brand to the sport or geographic area. This article offers the first real-world empirical investigation of the effects of visual congruence through color matching on sponsorship performance. A wide-scale study of 703 Major League Baseball fans’ evaluations of their team’s sponsors, merged with real stadium signage data, offers evidence of the benefits of visual congruence. Two experiments in the contexts of product packaging and online advertising provide converging evidence of the positive effects of created visual congruence on attitudes toward the sponsorship, brand attitudes, and intentions. Brands without an inherent match to a team can enjoy enhanced sponsorship benefits with little additional costs simply by adopting the team’s colors in visual displays. However, the viewer’s motivation (fan status), opportunity (fan exposure), and ability (lack of color blindness) to process visual congruence moderates its effectiveness. By using the proposed framework, managers can maximize the value of their sponsorship rights.
Adoption of Recommended Technologies by Sericulture Farmers in Krishnagiri District

Sericulture is an expanding industry in India. Among the sericulture developing country India stands second in the production of silk next to China. Sericulture plays a major role in the upliftment of rural population both socially and economically (Sreenivasa and Hiriyanna, 2014). Improved rearing techniques have been popularized on a large scale during the past 30 years in South India. As a result, it has been possible for the sericulturists adopting the new technique to step up the average yield from the earlier level of 40 kgs to 70 kgs/100 dfls at present. Also, total loss of one crop out of every 4-5 crop experienced earlier has been considerably reduced. Although, to a large extent, the new techniques have been fairly understood and practiced by most of the sericulturists today, the need still exists to educate them further and also others who are yet to take it, so that the average crop yield could be further improved to the level of 80 kgs/dfls. International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 8 Number 02 (2019) Journal homepage: http://www.ijcmas. com
A new model for customer purchase intention in e-commerce recommendation agents

Recommender systems were introduced to improve the online shopping experience by recommending appropriate products and services to customers according to their preferences. This research develops a new model by identifying the factors that influence customers’ purchase intention in recommender systems. The research model of this study was developed by reviewing the previous studies on web-based information systems, e-commerce and recommender systems. Quantitative data was collected from questionnaires Received: April, 2018 1st Revision: September, 2018 Accepted: November, 2018 Journal of International Studies S ci en ti fi c P a pe rs © Foundation of International Studies, 2018 © CSR, 2018 Journal of International Studies Vol.11, No.4, 2018 238 conducted among the customers of online shopping websites. The questionnaires was adopted from the previous researches, and validated by the experts in the fields of information systems and recommender systems. Descriptive and hypotheses’ analyses were performed on the collected data using statistical analysis software and Partial Least Squares Structural Equation Modeling. The results reveal that Accuracy, Diversity, Ease of Use, Recommendation Quality, Satisfaction, Trust and Usefulness have significant influence on customers’ intention to purchase a product recommended by the recommender systems. The developed model and the findings of this research will help e-commerce websites’ developers and e-commerce providers to enhance the recommender systems based on the factors that contribute to their quality.
Suppression of the persistent spin Hall current by defect scattering

We study the linear response spin Hall conductivity of a two-dimensional electron gas (2DEG) in the presence of the Rashba spin orbit interaction in the diffusive transport regime. When defect scattering is modeled by isotropic short-range potential scatterers the spin Hall conductivity vanishes due to the vertex correction. A non-vanishing spin Hall effect may be recovered for dominantly forward defect scattering.
Histomorphological and anatomical analysis of primary extra nodal non-Hodgkin lymphoma – ten years study from a tertiary cancer centre in South India

A substantial percentage of non-Hodgkin lymphomas (NHL) arise from tissue other than lymph nodes and even from sites which normally contain no lymphoid tissue. These forms are referred to as primary extranodal lymphomas (pENL). From January 2006 to December 2015, a total number of 1529 cases of NHL diagnosed definitely with lymphoma were included. Clinical information including demographics (age, gender) and initial site of involvement was collected. Out of 1529 cases 335 cases were of extranodal origin. This study was undertaken to ascertain the prevalence, anatomical distribution, and histological subtypes of extranodal non-Hodgkin lymphoma (NHL). This is one of the largest data from a single institution from a tertiary referral hospital in Southern India. Extranodal lymphomas constituted 335/1529 (21.9%) of all NHL. These included 209 males and 126 females (M: F= 1.65:1) and peak incidence was during the 4th to 5th decade of life. 296/335 (88.5%) of pENL had B immunophenotype whereas T cell phenotype was observed in only 39/335 patients (11.5%). GIT was the most common site of extranodal lymphomas in our study constituting 32% followed by head and neck 27.5%, CNS 8%, bone 7.5%, skin 7%, mediastinum 5%, testis 4%, soft tissue 3.8%, breast 1.49% and ovary 1%. The least common sites being kidney, urinary bladder, lung/pleura, primary liver and primary spleen. Diffuse large B-cell lymphoma, not otherwise specified (DLBCL) was the most common histological type observed in 172/286 (60%), followed by extranodal marginal zone lymphoma of MALT type 43/286 (15%). The most common histological subtype in children (age<18) was Burkitt lymphoma 20/49(41%) followed by DLBCL 10/49(20%). In adults stomach was the commonest site with DLBCL as frequent histomorphology while in paediatric population it was ileocaecum with Burkitt lymphoma. The incidence of pENL in Indian subcontinent is low compared to data from other parts of the world. Gastrointestinal tract and head and neck were the two most common extra nodal sites observed. The commonest site of involvement was GIT (32%). This is similar to the data from western studies, but differs from the other Indian studies in which head and neck lymphomas and PCNSL were the commonest. Head and neck was the second most common in our study, the reason being Waldeyer's ring and tonsils, were considered as nodal and were excluded from the study. However in many respects, historically they have been included among the extranodal types. Follicular lymphomas were conspicuously very low in the extranodal sites. Compared to published series, no difference was noted in regard to gender predilection and morphology.
The effects of topical doxepin on responses to histamine, substance P and prostaglandin E2 in human skin

The tricyclic antidepressant, doxepin, is known to have H1 and H2 antihistaminic effects. Recently, 5% doxepin cream has been marketed in the U.S.A. for treatment of eczematous dermatoses. We investigated the effects of topical doxepin treatment on histamine‐, substance P‐and prostaglandin E2‐(PGE2) induced responses in the skin of normal and atopic subjects. We compared the effects of topical doxepin with those of the oral antihistamine terfenadine. The weal volume and flare area responses to histamine were significantly reduced by treatment with topical doxepin or oral terfenadine in both normal and atopic subjects (P<0·05). The mean ±SEM percentage reduction in flare area for 10μ/site of histamine in non‐atopics and atopics was 48±8% and 60±17% with terfenadine, and 54 ± 12% and 81 ± 4% with topical doxepin, respectively. The mean percentage reduction in weal volume for the same dose of histamine in non‐atopics and atopics was 70 ± 9% and 63 ± 16% with terfenadine, and 96 ± 2% and 89 ± 6% with topical doxepin, respectively. The flare but not the weal response to substance P was inhibited by both treatments in all subjects (P<0·05). The mean ±SEM percentage reduction in flare area for 200 pmol/site of substance P in non‐atopics and atopics was 53 ± 10% and 73 ±4% with terfenadine, and 74 ± 7% and 75 ± 4% with topical doxepin, respectively. The cutaneous responses to PGE2 were not affected by either drug. The inhibitory effects of doxepin were as great as those of terfenadine, and doxepin had a significantly greater effect than terfenadine in inhibiting the weal response to histamine and flare response to substance P in normal volunteers (P<0·05). There was no significant difference between atopics and non‐atopics in the percentage reduction of cutaneous responses by oral terfenadine or topical doxepin. Marked sedation occurred in three of the first 10 subjects treated with topical doxepin, necessitating a reduction in dosage for the remaining six subjects. In summary, topical doxepin was as effective as, and sometimes more effective than, a standard dose of oral terfenadine in the inhibition of histamine‐induced and axon‐reflex‐mediated cutaneous responses. The marked sedative effect may limit its clinical use in some patients.
Biochemical Evidence That phaZ Gene Encodes a Specific Intracellular Medium Chain Length Polyhydroxyalkanoate Depolymerase in Pseudomonas putida KT2442

Polyhydroxyalkanoates (PHAs) can be catabolized by many microorganisms using intra- or extracellular PHA depolymerases. Most of our current knowledge of these intracellular enzyme-coding genes comes from the analysis of short chain length PHA depolymerases, whereas medium chain length PHA (mcl-PHA) intracellular depolymerization systems still remained to be characterized. The phaZ gene of some Pseudomonas putida strains has been identified only by mutagenesis and complementation techniques as putative intracellular mcl-PHA depolymerase. However, none of their corresponding encoded PhaZ enzymes have been characterized in depth. In this study the PhaZ depolymerase from P. putida KT2442 has been purified and biochemically characterized after its overexpression in Escherichia coli. To facilitate these studies we have developed a new and very sensitive radioactive method for detecting PHA hydrolysis in vitro. We have demonstrated that PhaZ is an intracellular depolymerase that is located in PHA granules and that hydrolyzes specifically mcl-PHAs containing aliphatic and aromatic monomers. The enzyme behaves as a serine hydrolase that is inhibited by phenylmethylsulfonyl fluoride. We have modeled the three-dimensional structure of PhaZ complexed with a 3-hydroxyoctanoate dimer. Using this model, we found that the enzyme appears to be built up from a coreα/β hydrolase-type domain capped with a lid structure with an active site containing a catalytic triad buried near the connection between domains. All these data constitute the first biochemical characterization of PhaZ and allow us to propose this enzyme as the paradigmatic representative of intracellular endo/exo-mcl-PHA depolymerases.
CR1 is associated with amyloid plaque burden and age‐related cognitive decline

Recently, genome‐wide association studies have identified 3 new susceptibility loci for Alzheimer's disease (AD), CLU, CR1, and PICALM. We leveraged available neuropsychological and autopsy data from 2 cohort studies to investigate whether these loci are associated with cognitive decline and AD neuropathology.
“ONE MORE WAY TO SELL NEW ORLEANS”: AIRBNB AND THE COMMODIFICATION OF AUTHENTICITY THROUGH LOCAL EMOTIONAL LABOR

OF THESIS “ONE MORE WAY TO SELL NEW ORLEANS”: AIRBNB AND THE COMMODIFICATION OF AUTHENTICITY THROUGH LOCAL EMOTIONAL LABOR Since 2014, Airbnb has been the poster-child for an impassioned debate over how to best regulate short-term home rentals (STR’s) in New Orleans, Louisiana. As critical perspectives toward on-demand economic practice become increasingly common, it is important to understand how the impacts of STR platforms like Airbnb extend beyond the realm of what is traditionally conceptualized as the economic (i.e., pressure on housing markets). In this thesis, I explore the ways in which Airbnb recalibrates the spatial and temporal rhythms of everyday neighborhood life for people external to the formal trappings of an STR contract. Drawing in particular on theories of authenticity and feminist political economy, I argue that locals’ emotional labor of “playing host” is necessarily enrolled into the creation of value for Airbnb, and is essential to the reproduction of the platform’s business model and marketing rhetoric.
Molecular biology of endometrial carcinoma prognostic factors

The term tumour is understood as a general denomination for newly formed tissue formation or cell populations in an organism that do not develop as a physiological response to external or internal stimuli, show abnormality signs and more or less escape the regulatory influence of the surrounding cells and organism. Currently, a general opinion has been accepted that tumours result from congenital or acquired genetic damage. Thus, the spectrum of formerly suggested theories of carcinogenesis has narrowed down to a single genetic theory. It is therefore necessary to emphasize that regardless of malignant growth being sporadic for the individual or recurrent for many family members as a hereditary trait, it is clearly a genetic disease.
The Impacts of Sharia Bank Customers’ Awareness and Attitudes towards Islamic Working Capital Financing Use in Indonesia

The high Gini Index of Indonesia indicates that the economic growth is not accompanied by equal incomedistribution. This study aimed to determine the awareness and attitudes of the Muslim consumers of sharia banks this study was developed based on AIDA’s hierarchy of effects model and the theory of planned behavior. Structural variables. The primary data collection was performed through self-administered questionnaire with 125 Muslim consumers of sharia banks in Indonesia who own business. The main result suggests that to increase the market share of sharia banking in Indonesia, and eventually to reduce poverty rate and income inequality, is to increase the initiative should begin with simultaneous paradigm shift from all parties involving the Muslim community, sharia banking, and government. The required paradigm shift refers to making sharia banking as the way of life of Muslims
Neonatal cutaneous fungal infections

Purpose of review Cutaneous fungal infections are not uncommon in newborns and are seen in premature or otherwise immunocompromised neonates as well as in healthy full-term neonates. Healthy newborns can develop clinical manifestations as a result of infection with Candida species or as a result of skin colonization with Malassezia species; cutaneous infection with other fungal pathogens is rare. Immunocompromised and premature neonates, however, are susceptible to infection with opportunistic pathogens and are also at higher risk for invasive infection with common pathogens such as Candida. This review discusses the fungal species associated with cutaneous fungal infection in neonates, emphasizes the relevant clinical features, and also reviews the use of newer antifungal agents, including lipid-associated amphotericin B, voriconazole, and caspofungin. Recent findings Neonatal cutaneous infections with opportunistic fungal pathogens, including Aspergillus and the Zygomycetes, have been reported with increasing frequency as advances in neonatal care have improved the survival rate in very low birthweight neonates. Although these infections are frequently fatal, survival in some neonates has been reported with the use of aggressive surgical debridement and systemic antifungal therapy. Newer antifungal agents, including voriconazole and caspofungin, show promise in the treatment of potentially fatal fungal infections in neonates. Summary Cutaneous fungal infections in neonates range from generally benign conditions such as congenital candidiasis and neonatal cephalic pustulosis to potentially fatal infections with opportunistic pathogens in very low birthweight or immunocompromised neonates. The prompt recognition and appropriate treatment of cutaneous fungal disease in neonates is critical to the prevention of adverse outcomes.
Barriers to environmental sustainability of construction projects

Purpose The construction industry plays an important role in the achievement of the 11th and 15th of the Sustainable Development Goals. Efforts have been made by most developing and developed economies toward the achievement of these goals. Despite the efforts being made by the construction industry toward the achievement of these goals, there are still barriers that prevent built environment consultants from advancing environmental sustainability (ES) of construction projects. The purpose of this paper is to identify barriers to ES of construction projects. Design/methodology/approach An extensive literature review on barriers to the adoption of ES was conducted and face-to-face semi-structured interviews of purposively selected built environment consultants in Ghana were carried out. Thematic template analysis of qualitative data was conducted. Findings The key findings from the study include perceived initial costs, lack of knowledge on ES, technological difficulties, external pressures in adopting ES practices and environmental conditions in developing countries. Originality/value The outputs of this study offer strategies which are very significant to the construction industry in embracing ES. Further, the findings contribute to knowledge on achieving the sustainable development agenda.