Miracle-dz/UniFAR-FTUs huggingface dataset:
Unsupervised Perceptual Rewards for Imitation Learning

Reward function design and exploration time are arguably the biggest obstacles to the deployment of reinforcement learning (RL) agents in the real world. In many real-world tasks, designing a reward function takes considerable hand engineering and often requires additional sensors to be installed just to measure whether the task has been executed successfully. Furthermore, many interesting tasks consist of multiple implicit intermediate steps that must be executed in sequence. Even when the final outcome can be measured, it does not necessarily provide feedback on these intermediate steps. To address these issues, we propose leveraging the abstraction power of intermediate visual representations learned by deep models to quickly infer perceptual reward functions from small numbers of demonstrations. We present a method that is able to identify key intermediate steps of a task from only a handful of demonstration sequences, and automatically identify the most discriminative features for identifying these steps. This method makes use of the features in a pre-trained deep model, but does not require any explicit specification of sub-goals. The resulting reward functions can then be used by an RL agent to learn to perform the task in real-world settings. To evaluate the learned reward, we present qualitative results on two real-world tasks and a quantitative evaluation against a human-designed reward function. We also show that our method can be used to learn a real-world door opening skill using a real robot, even when the demonstration used for reward learning is provided by a human using their own hand. To our knowledge, these are the first results showing that complex robotic manipulation skills can be learned directly and without supervised labels from a video of a human performing the task. Supplementary material and data are available at this https URL
'High and Dry': the Liquidity and Credit of Colonial and Foreign Government Debt in the London Stock Exchange (1880-1910)

We gather the most comprehensive database of government bonds for the first globalisation era to date to conduct the first historically informed study of the importance of liquidity for colonial and sovereign yield spreads. Considering both liquidity and credit shows that the two markets were segmented: credit was the most important factor in the pricing of sovereign debt, but liquidity predominated in the colonial market, explaining 10% to 39% of colonial yield spreads. This reflected both different market microstructures and bond clienteles, themselves influenced by heterogeneous political, institutional and financial arrangements. The flows from the colonies to British ‘ordinary’ investors in the form of illiquidity premia should be taken into account in future studies of the political economy of empire.
Androgen-IndependentMolecular Imaging Vectors to Detect Castration-Resistant and Metastatic Prostate Cancer

Prostate-specific promoters are frequently employed in gene-mediated molecular imaging and therapeutic vectors to diagnose and treat castration-resistant prostate cancer (CRPC) that emerges from hormone ablation therapy. Many of the conventional prostate-specific promoters rely on the androgen axis to drive gene expression. However, considering the cancer heterogeneity and varying androgen receptor status, we herein evaluated the utility of prostate-specific enhancing sequence (PSES), an androgen-independent promoter in CRPC. The PSES is a fused enhancer derived from the prostate-specific antigen (PSA) and prostate-specific membrane antigen gene regulatory region. We augmented the activity of PSES by the two-step transcriptional amplification (TSTA) system to drive the expression of imaging reporter genes for either bioluminescent or positron emission tomography (PET) imaging. The engineered PSES–TSTA system exhibits greatly elevated transcriptional activity, androgen independency, and strong prostate specificity, verified in cell culture and preclinical animal experimentations. These advantageous features of PSES–TSTA elicit superior gene expression capability for CRPC in comparison with the androgen-dependent PSA promoter–driven system. In preclinical settings, we showed robust PET imaging capacity of PSES–TSTA in a castrated prostate xenograft model. Moreover, intravenous administrated PSES–TSTA bioluminescent vector correctly identified tibial bone marrow metastases in 9 of 9 animals, whereas NaFand FDG-PET was unable to detect the lesions. Taken together, this study showed the promising utility of a potent, androgen-independent, and prostate cancer–specific expression system in directing gene-based molecular imaging in CRPC, even in the context of androgen deprivation therapy. Cancer Res; 71(19); 1–11. 2011 AACR.
Racial/ethnic differences in activities of daily living disability in older adults with arthritis: a longitudinal study.

OBJECTIVE To investigate racial/ethnic differences in disability onset among older Americans with arthritis. Factors amenable to clinical and public health intervention that may explain racial/ethnic differences in incident disability were examined. METHODS We analyzed longitudinal data (1998-2004) from a national representative sample of 5,818 non-Hispanic whites, 1,001 African Americans, 228 Hispanics interviewed in Spanish (Hispanic/Spanish), and 210 Hispanics interviewed in English (Hispanic/English), with arthritis and age >or=51 years who did not have baseline disability. Disability in activities of daily living (ADL) was identified from report of inability, avoidance, or needing assistance to perform >or=1 ADL task. RESULTS Over the period of 6 years, 28.0% of African Americans, 28.5% of Hispanic/Spanish, 19.1% of Hispanic/English, and 16.2% of whites developed disability. The demographic-adjusted disability hazard ratios (AHR) were significantly greater among African Americans (AHR 1.94, 95% confidence interval [95% CI] 1.51-2.38) and Hispanic/Spanish (AHR 2.03, 95% CI 1.35-2.71), but not significantly increased for Hispanic/English (AHR 1.41, 95% CI 0.82-2.00) compared with whites. Differences in health factors (comorbid conditions, functional limitations, and behaviors) explained over half the excess risk among African Americans and Hispanic/Spanish. Medical access factors (education, income, wealth, and health insurance) were substantial mediators of racial/ethnic differences in all minority groups. CONCLUSION Racial/ethnic differences in the development of disability among older adults with arthritis were largely attenuated by health and medical access factors. Lack of health insurance was particularly problematic. At the clinical level, treatment of comorbid conditions, functional limitations, and promotion of physical activity and weight maintenance should be a priority to prevent the development of disability, especially in minority populations.
Emotion differentiation dissected: between-category, within-category, and integral emotion differentiation, and their relation to well-being

ABSTRACT Emotion differentiation, the ability to describe and label our own emotions in a differentiated and specific manner, has been repeatedly associated with well-being. However, it is unclear exactly what type of differentiation is most strongly related to well-being: the ability to make fine-grained distinctions between emotions that are relatively closely related (e.g. anger and irritation), the ability to make larger distinctions between very distinct emotions (e.g. anger and sadness), or the combination of both. To determine which type of differentiation is most predictive of well-being, we performed a comprehensive meta-analysis across six datasets. We examined the correlations between these three types of differentiation and several indicators of well-being (depression, emotional clarity, and self-esteem). Results showed that individuals differentiated most between very distinct emotions and least between more related emotions, and that an index computed across emotions from both the same and different emotion categories was most strongly associated with well-being indicators.
Stability of asymmetric Hopfield networks

In this paper, we discuss dynamical behaviors of recurrently asymmetrically connected neural networks in detail. We propose an effective approach to study global and local stability of the networks. Many of well known existing results are unified in our framework, which gives much better test conditions for global and local stability. Sufficient conditions for the uniqueness of the equilibrium point and its stability conditions are given, too.
Effects of a DVD-based seated dual-task stepping exercise on the fall risk factors among community-dwelling elderly adults.

OBJECTIVE The purpose of this randomized control trial study was to evaluate the effectiveness of a digital video disc (DVD)-based seated dual-task (DT) stepping exercise to improve the DT walking capability in elderly people. In the DT exercise, participants were asked to perform a verbal fluency task while stepping as quickly as possible. METHODS Eight clusters (n=93) randomized into a DVD group (4 clusters, n=48) and a nonexercise control group (4 clusters, n=45) participated in this trial. In the DVD group, participants received 20 min of group training twice a week for 24 weeks. The exercise class used an exercise DVD that included a 15-min basic exercise and a 5-min DT exercise. No exercise program was prescribed for the control group. The measurements were based on the difference in physical function, including DT walking, between the DVD and control groups. In the DT walking test, participants walked individually at a comfortable speed while carrying a ball on a tray. The relative DT lag was calculated by using simple walking as the comparison condition. The Timed Up and Go test and the 5-chair stand test were also performed. RESULTS The median relative adherence to the study was 87.5% (25th-75th percentile, 83.3%-95.8%) in the DVD group. The outcome measurements, including the DT walking time and DT time lag (p<0.05), among participants in the DVD group were significantly improved. However, other outcome measurements were not significantly different between the two groups (p>0.05). CONCLUSION The current study reports the effectiveness of a DVD-based exercise for the improvement of the DT walking capability. A larger study is needed to confirm the present results. Study of a Web-based exercise regime would be valuable to identify the most effective exercise for prevention of falls and fall-related fractures.
Damage localization of closing cracks using a signal decomposition technique

Fatigue cracks are a common occurrence in engineering structures subjected to dynamic loading and need to identify at its earliest stage before it leads to catastrophic failure. The presence of fatigue-breathing crack or closing cracks is usually characterised by the presence of sub, super-harmonics, and inter-modulation in the response of the structure subjected to harmonic excitation. It should be mentioned here that the amplitude of nonlinear harmonics are of very less order in magnitude when compared to linear or excitation component. Further, these nonlinear components often get buried in noise as both are having matched (low) energy levels. The present work attempts to decompose the acceleration time history response using singular spectrum analysis and propose a strategy to extract the nonlinear components from the residual noisy time history component. A new damage index based on these extracted nonlinear features is also proposed for closing crack localization. The effectiveness of the proposed closing crack localization approach is illustrated using detailed numerical studies and validated with lab level experimentation on the simple beam-like structure. It can be concluded from the investigations that the proposed signal decomposition based damage localization technique can detect and locate more than one crack present in the structure.
High risk for bilateral Warthin tumor in heavy smokers – review of 185 cases

Conclusions. We identified smoking as a significant risk factor for multilocular Warthin tumor development. Therefore, we recommend taking history of smoking into account when making the decisions for surgical strategy. Objectives. Warthin tumor is a common benign neoplasm of the parotid gland. Risk factors for multilocular development have not been defined. Patients and methods. A total of 185 consecutive patients treated for Warthin tumor were included. Charts were reviewed for symptoms, risk factors, and diagnostic and surgical procedures. Patients were followed for facial function and recurrence. Risk factors were evaluated. Results. Overall, in 203 parotid operations, a lateral parotidectomy (77%) was performed in most cases; 94% were primary surgery and 6% were revision surgery. In 89% of patients swelling was the only symptom. Bilateral Warthin tumor was seen in 17% of patients. Of these cases synchronous and metachronous bilateral tumors were observed in 61% and 39%, respectively. The median time period for second contralateral tumor development was 7 years. Postoperative transient facial dysfunction was observed in 31%, which recovered within 3 months in all cases. Evaluation of risk factors revealed that 89% of the subjects were smokers and 66% were heavy smokers. The risk for bilateral Warthin tumors correlated significantly with the amount of nicotine intake (p=0.003).
Hint for association of single nucleotide polymorphisms and haplotype in SPINK5 gene with atopic dermatitis in Koreans

Abstract: Clinical studies, including twin studies, support the concept that the risk of atopic dermatitis (AD) may be mediated through skin‐specific genes, rather than simply through systemic immune or atopy risk genes. The SPINK5 gene is expressed on epithelial surfaces and may provide protection against other allergenic serine proteases. Mutations in the SPINK5 gene result in Netherton syndrome, a disorder characterised by AD, ichthyosis, and elevated serum IgE levels. We genotyped 21 single nucleotide polymorphisms (SNPs) from the SPINK5 gene for 1090 case–control samples (631 patients with AD and 459 normal controls) and analysed the SNPs and haplotypes in this gene and also searched for gene–gene interactions between SPINK5 and the DEFB1 gene that we previously reported. Six SNPs [rs17718511 (P = 0.026), rs17860502 (P = 0.024), KN0001820 (P = 0.045), rs60978485 (P = 0.007), rs17718737 (P = 0.02), and rs1422985 (P = 0.038)] and the haplotype TAA (rs60978485, rs6892205, rs2303064; P = 0.023) in the SPINK5 gene showed significant different allelic or genotypic distributions between the AD group and the control group. We also found that four SNPs [rs17718511 (P = 0.033), rs17860502 (P = 0.031), rs60978485 (P = 0.005), rs17718737 (P = 0.023)] and the haplotype TAA (P = 0.02) in the SPINK5 gene showed associations with the susceptibility of the allergic type of AD (ADe). In addition to this finding, we speculate that the SNPs from DEFB1 and SPINK5 affect the individual susceptibility to development of ADe in an additive manner. This study provides evidence for a significant interaction between allergens and the SPINK5 gene that may contribute to ADe susceptibility.
Macroeconomic Stability, Financial Risks and Market Eciency: Evidence for a Small and Open Economy

We analyze whether changes in external macroeconomic conditions are associated with changes in the dynamics of risk and changes in the degree of informativeness of the price system for the Chilean economy. By focusing our analysis in Chile, we hope to isolate the effect of external macroeconomic volatility from the effects that weak institutions or a poor rule of law might have over domestic markets performance. We find that the dynamics of local financial risks is associated with the evolution of the overall economic conditions of the country, with a strong reduction in idiosyncratic and systematic risks during periods of stable macroeconomic conditions. Since the level and composition of financial risks can affect the net benefits of acquiring and trading on private information, we conjecture that external economic conditions can also affect the informativeness of domestic stock prices. We find that the ability of domestic stock prices to reflect fundamentals information improves during times of stable external conditions. In spite of this, we provide evidence that traditional measures of informationally market efficiency in the R2 literature fail to detect such changes and attempt to explain the reason behind the inability of these measures to properly proxy for stock price informativeness.
The impact of meaningful high school computer science experiences in the Chicago Public Schools

We report on initial outcomes of the Taste of Computing project, under which a meaningful computer science course has been initiated in many high schools of the Chicago Public Schools system. Surveys of students have shown that they attribute high value to the course and have experienced increases in their understanding and interest regarding the computing field. Data was also collected from teachers participating in professional development regarding their preparation and confidence in teaching the new course. We report on the strengths of various survey responses and their relationships, and we compare student responses by race and gender. The data provide a good basis for exploring the impact of meaningful computer science instruction on students from groups under represented in computing; of several hundred students surveyed, nearly half were female, and over half were Hispanic or African-American.
Intra-aortic balloon pump combined with mechanical ventilation for treating patients aged > 60 years in cardiogenic shock: Retrospective analysis

Objective To examine if mechanical ventilation with positive end-expiratory pressure (PEEP) combined with intra-aortic balloon pump (IABP) provided a better outcome than IABP alone for the treatment of cardiogenic shock after acute myocardial infarction in patients aged > 60 years. Methods This was a retrospective analysis of data from patients in cardiogenic shock, refractory to pharmacological therapy and treated at a geriatric coronary care unit. Results Sixty-two patients were eligible for study inclusion: 33 received IABP alone; 29 received IABP combined with mechanical ventilation. Patients in the IABP + mechanical ventilation group had lower mean arterial blood pressure (BP), systolic BP and partial pressure of oxygen compared with the IABP group, indicating worse cardiac and pulmonary function. In addition, higher rates of pulmonary infection and renal insufficiency were observed in the IABP + mechanical ventilation group than in the IABP group. A statistically significant improvement of left ventricular function before and after treatment was observed in the IABP + mechanical ventilation group, but not in the IABP group. Pulmonary infection and renal insufficiency were risk factors for all-cause in-hospital mortality; successful revascularization was a negative risk factor. There was no between-group difference in survival. Conclusion Mechanical ventilation with an appropriate level of PEEP appears to enhance the beneficial effects of IABP on left ventricular function for patients in cardiogenic shock.
The aid-income link revisited. How plausible and robust are the results?

This study provides a re-examination of the aid-income link based on a panel data set which is downloadable at the Canadian Journal of Economics 45(1), 2012 issue. Longer time series data are available for a group of 58 countries and run from 1960 to 2007. In particular, the study aims at justifying the use of time series techniques and re-investigating whether the more recent finding that aid has an insignificant impact on per capita income is plausible and robust. Plausibility is checked by looking at the transmission channels of aid and by testing the direction of causality between aid and income and robustness is checked by investigating sub-samples of the 58 countries and by refining the model. In particular, we allow for threshold effects of aid, considering that aid might become effective after certain threshold values of other growth-determining factors have been achieved. Overall, we find that the result of an insignificant impact of aid on per capita income is robust taking a long-run perspective. Not being able to establish a significant impact of aid on income in the long run does not rule out that in the short to medium run significant positive (or negative) effects of aid can appear and, therefore, a positive short-run contribution of aid is a possible result and no counter-evidence for the findings related to the long run. In addition, we do not find any evidence that would justify the use of a model with interaction terms or with thresholds.
Vascular endothelial growth factor administration in chronic myocardial ischemia.

Vascular endothelial growth factor (VEGF) is a potent mitogen capable of stimulating angiogenesis. We examined the effect of VEGF administration in a model of chronic porcine myocardial ischemia. Nineteen pigs were instrumented with proximal left circumflex coronary artery (LCX) Ameroid constrictors. In eight animals VEGF (2 microgram) with heparin (50 U) was administered extraluminally to the LCX myocardium with an osmotic pump for 4 wk and 11 other animals served as controls. VEGF-treated animals demonstrated higher flow in the LCX territory during both rest and pacing compared with untreated controls (rest: 1.35 +/- 0.1 vs. 0.80 +/- 0.09 ml.min-1.g-1; pacing; 2.01 +/- 0.37 vs. 1.01 +/- 0.07 ml.min-1.g-1, P < 0.05, VEGF vs. controls). The observed improvement in regional coronary flow in VEGF-treated animals resulted in better preservation of endothelium-dependent microvessel relaxation as well as fractional LV shortening in the LCX territory during pacing in the VEGF-treated than in control animals (controls: 7.1 +/ 2.6 vs. 3.6 +/- 2.0%, rest vs. pacing; VEGF: 6.9 +/- 2.9 vs. 6.3 +/- 2.9%, rest vs. pacing). We conclude that VEGF administration in a gradual coronary occlusion model in pigs results in improvement of coronary flow and preservation of regional hemodynamics in the compromised myocardium.
High Omega-3 Fat Intake Improves Insulin Sensitivity and Reduces CRP and IL6, but does not Affect Other Endocrine Axes in Healthy Older Adults

Aging diminishes hormone secretion and target cell responsiveness, possibly due to loss of cell membrane fluidity or alteration of membrane phospholipids affecting signal transduction. We investigated whether a high omega-3 polyunsaturated fatty acid diet would improve endocrine function in 6 men and 6 women aged over 60 years. Subjects first ate an isocaloric control diet for 6 weeks, followed by an 8-week experimental diet, which included 720 g of fatty fish weekly plus 15 ml of sardine oil daily. In the last week, we measured RBC membrane fatty acids on each diet, performed pituitary, adrenal, hepatic, and Leydig cell endocrine provocative testing, and assayed selected cytokines. We also assessed insulin sensitivity utilizing octreotide insulin suppression testing and assessed free fatty acid (FFA) responses to isoproteronol. Insulin sensitivity increased significantly after 8 weeks on the omega-3 diet and FFA responses trended lower. Serum C-reactive protein was significantly reduced and a trend towards lower IL-6 was noted. No differences were found in other metabolic parameters, adiponectin levels, or hormone responses. We conclude that, in older people, high omega-3 consumption increases insulin sensitivity, may reduce FFA mobilization by catecholamines, and reduces inflammatory markers, but did not alter endocrine responsiveness after 8 weeks.