Miracle-dz/UniFAR-FTUs huggingface dataset:
cAb-Rep: A Database of Curated Antibody Repertoires for Exploring Antibody Diversity and Predicting Antibody Prevalence

The diversity of B cell receptors provides a basis for recognizing numerous pathogens. Antibody repertoire sequencing has revealed relationships between B cell receptor sequences, their diversity, and their function in infection, vaccination, and disease. However, many repertoire datasets have been deposited without annotation or quality control, limiting their utility. To accelerate investigations of B cell immunoglobulin sequence repertoires and to facilitate development of algorithms for their analysis, we constructed a comprehensive public database of curated human B cell immunoglobulin sequence repertoires, cAb-Rep (https://cab-rep.c2b2.columbia.edu), which currently includes 306 immunoglobulin repertoires from 121 human donors, who were healthy, vaccinated, or had autoimmune disease. The database contains a total of 267.9 million V(D)J heavy chain and 72.9 million VJ light chain transcripts. These transcripts are full-length or near full-length, have been annotated with gene origin, antibody isotype, somatic hypermutations, and other biological characteristics, and are stored in FASTA format to facilitate their direct use by most current repertoire-analysis programs. We describe a website to search cAb-Rep for similar antibodies along with methods for analysis of the prevalence of antibodies with specific genetic signatures, for estimation of reproducibility of somatic hypermutation patterns of interest, and for delineating frequencies of somatically introduced N-glycosylation. cAb-Rep should be useful for investigating attributes of B cell sequence repertoires, for understanding characteristics of affinity maturation, and for identifying potential barriers to the elicitation of effective neutralizing antibodies in infection or by vaccination.
Progressive Advance in Supply chain management of Regional Socio-Economic Development: Conceptual Framework and Evaluation Mechanism

At present, a large number of methodologies have been developed aimed at assessing and forecasting the potential of the socio-economic development of certain regions. It should be noted that human and social capabilities as the key elements of regional development are currently the least studied issues. Therefore, in this work, along with economic factors, considerable attention is paid to the assessment of human potential and the social component of the workforce. Unlike political, economic and investment factors, these elements are subject to changes in the short-run, and are engines of regional development and the most promising of its components. The purpose of the study is to develop a mechanism for assessing the level of regional development and identifying factors affecting this process. The implementation of this procedure in practice is especially significant when planning and adjusting activities related to regional management. Deepening and developing previous studies, in this paper we synthesize known approaches to assessing regional socio-economic development, offer our own set of criteria for evaluating advancements and test the developed approach as exemplified by the regions of the Central Federal District in Russia. The scientific novelty of the study is that to assess the regional socio-economic development we propose evaluation of the level of advancement. To do this, all the indicators included in the model are considered dynamically and are evaluated by the corresponding indices. Such an approach will make it possible to assess the prospects for the development of the factor under study and make timely adjustments to the regional policy. The objects of research in this paper are the regions of the Central Federal District in Russia. The subjects of the study are the factors that cause advancements in regional economic development. The following research methods are used: retrospective analysis, statistical observation method, correlation analysis, principles and methods of system analysis and, computational procedures based on the use of financial mathematics and financial management tools.
The effect of inspired oxygen concentration on postoperative pulmonary atelectasis in obese patients undergoing laparoscopic cholecystectomy: a randomized-controlled double-blind study

Introduction Atelectasis is the most important postoperative pulmonary complication in obese patients following general anaesthesia. The study aimed to determine the effect of inspired high versus low oxygen concentration on pulmonary atelectasis in obese patients undergoing laparoscopic cholecystectomy. Patients and methods A total of 60 patients, American Society of Anesthesiologists I–II, of both sexes, aged 20–60 years, BMI more than 30 kg/m2 and scheduled for elective laparoscopic cholecystectomy were randomly assigned to group I inspired 40% oxygen and group II inspired 90% oxygen after endotracheal intubation and for 2 h postoperatively. The effect of inspired oxygen concentration on atelectasis approved by computed tomographic scan and radiography was determined 24 h after surgery. Oxygen saturation, the partial pressure of arterial oxygen and carbon dioxide, tension, pulmonary functions and haemodynamic parameters were also recorded. Results Atelectasis was detected by computed tomography scans of the chest performed in the first postoperative day in 60% of patients in group I, whereas it was detected in 76.7% of patients in group II without significant difference between the groups, and it was determined in 33% of patients in group I compared with 46% of patients in group II, without significant difference between the two groups by radiographic examination. Postoperative forced vital capacity and forced expiratory volume in 1 s were significantly reduced in the two groups compared with the preoperative values in both groups without significant difference between the two groups. The intraoperative partial pressure of arterial oxygen values showed an insignificant change in the postoperative measurements between the groups. Conclusion Administration of low percentage of oxygen concentration (40%) was associated with decreased incidence of atelectasis without worsening of pulmonary function.
Quality of Institutions and the Allocation of Talent: Cross‐National Evidence

Strong institutions attract talent to productive activities, whereas weak ones raise the appeal of redistribution. We find a strong positive cross&#8208;country association between the quality of institutions and graduation of university students in science, and an even stronger negative correlation with graduation in law. These findings are robust to various specifications of empirical models. We also demonstrate that institutions dominate other factors affecting the allocation of talent. Finally, we present direct evidence that (mis)allocation of talent between productive and unproductive activities driven by institutional quality explains the discrepancy between private and public returns to education.
Enteral feeding is associated with longer survival in the advanced stages of prion disease

Abstract To report the frequency, complications, survival and motivations for enteral feeding in UK patients with prion diseases. We analysed data from an ongoing prospective observational cohort study of UK patients with prion diseases (n = 635). Gastrostomy-treated cases were matched by age, gender, disease aetiology, severity, duration and a genetic predictor of survival (ratio 1:3.1). The main outcome was survival (unadjusted log-rank test); secondary outcomes were future functional impairments, complications and retrospective carer interviews to determine qualitative benefits and motivations. Enteral feeding is uncommon in UK patients with prion diseases (n = 26/635; 4.1%), but more frequent in acquired (7/41, 17.1%) and inherited (7/128, 5.5%) compared with sporadic disease (12/466, 2.6%; P = 3 × 10−5 chi-squared), and used mostly at advanced stages. Enteral feeding was complicated by infection and the need for reinsertions, but associated with markedly longer survival at advanced neurodisability (median 287 days, range 41–3877 versus 17 days, range 0–2356; log-rank test in three aetiologies each P < 0.01). Interviews revealed different motivations for enteral feeding, including perceived quality of life benefits. We provide Class II evidence that enteral feeding prolongs the akinetic-mute phase of all aetiological types of prion disease. These data may help support decision making in palliative care. Enteral feeding is an important potential confounder in prion disease clinical trials that use survival as an endpoint.
MHC Class I Molecules Exacerbate Viral Infection by Disrupting Type I Interferon Signaling

MHC class I molecules are key in the presentation of antigen and initiation of adaptive CD8+ T cell responses. In addition to its classical activity, MHC I may possess nonclassical functions. We have previously identified a regulatory role of MHC I in TLR signaling and antibacterial immunity. However, its role in innate antiviral immunity remains unknown. In this study, we found a reduced viral load in MHC I-deficient macrophages that was independent of type I IFN production. Mechanically, MHC I mediated viral suppression by inhibiting the type I IFN signaling pathway, which depends on SHP2. Cross-linking MHC I at the membrane increased SHP2 activation and further suppressed STAT1 phosphorylation. Therefore, our data revealed an inhibitory role of MHC I in type I IFN response to viral infection and expanded our understanding of MHC I and antigen presentation.
Findings of the WMT 2019 Shared Task on Automatic Post-Editing

We present the results from the 5th round of the WMT task on MT Automatic Post-Editing. The task consists in automatically correcting the output of a “black-box” machine translation system by learning from human corrections. Keeping the same general evaluation setting of the previous four rounds, this year we focused on two language pairs (English-German and English-Russian) and on domain-specific data (In-formation Technology). For both the language directions, MT outputs were produced by neural systems unknown to par-ticipants. Seven teams participated in the English-German task, with a total of 18 submitted runs. The evaluation, which was performed on the same test set used for the 2018 round, shows a slight progress in APE technology: 4 teams achieved better results than last year’s winning system, with improvements up to -0.78 TER and +1.23 BLEU points over the baseline. Two teams participated in theEnglish-Russian task submitting 2 runs each. On this new language direction, characterized by a higher quality of the original translations, the task proved to be particularly challenging. None of the submitted runs improved the very high results of the strong system used to produce the initial translations(16.16 TER, 76.20 BLEU).
Mangrove Productivity Estimation using Modelling Approach and Tree Parameters Assessment

This study used productivity models and above ground biomass to investigate productivity in different sites of MMFR. Ninety Rhizophora apiculata leaf samples were collected from different compartments (18, 31, 71, 74, 42 and 55) based on tree age and management. For biomass calculation, tree height and diameter were measured in plot of 10m x 10m in compartment 18, 31, 71, 74 and 67. The age of the trees were as follows: compartment 18 and 31 with 15-year-old, compartment 71 and 74 with 25-year-old and compartment 67 with 30-year-old mangrove trees. Compartment 42 and 55 are classified as virgin jungle reserve (VJR). Compartment 67 was not taken as a sample site due to technical reason and compartments in VJR were not considered for biomass estimation. Sixteen variables; stable isotopes (δ13C, δ15N), macronutrients (C, N, P), cations (Ca, Mg, Na, K) and trace elements (Cd, Cu, Fe, Mn, Pb, Zn) were analyzed. Productivity models and calculated biomass for investigated compartments showed similar trends. In 15-year age group; compartment 18 showed higher productivity than in 31. For the 25-year age group; compartment 74 had higher productivity than 71. No prominent increase was observed in biomass between 15-year old and 30-year old trees. Furthermore, with moderate N and δ15N loading input, compartments showed more productivity. The results conclude that MMFR is a sustainably managed mangrove forest and its productivity could be monitored using nutrient productivity models.
Biodentine™ Partial Pulpotomy of a Young Permanent Molar with Signs and Symptoms Indicative of Irreversible Pulpitis and Periapical Lesion: A Case Report of a Five-Year Follow-Up

The purpose of this paper was to report the five-year success of Biodentine™ partial pulpotomy in a young permanent molar, with signs and symptoms indicative of irreversible pulpitis and periapical lesion, in a nine-year-old girl. Preoperative clinical examination revealed a large carious lesion of the left mandibular permanent first molar. The patient reported pain on percussion. The tooth responded positively to the electric pulp test and had lingering pain after cold testing. A periapical radiograph showed a deep carious lesion and periapical lesion. Based on the clinical and radiographical examination, the tooth had signs and symptoms indicative of irreversible pulpitis and periapical lesion. During caries removal, pulp exposure occurred, and 2-3 mm in depth of pulp tissue at the exposure site was removed. Haemorrhage was controlled within four minutes with 2.5% sodium hypochlorite-moistened cotton pellets. Biodentine™ was then applied as both a pulp dressing and a temporary restoration. At the following visit, composite resin was placed over the Biodentine™ as a final restoration. During a five-year follow-up, the tooth was asymptomatic, had positive responses to sensibility tests, and had no discolouration. Follow-up radiographs showed a dentine bridge and periapical healing.
Glutamine Metabolism Is Essential for Stemness of Bone Marrow Mesenchymal Stem Cells and Bone Homeostasis

Skeleton has emerged as an endocrine organ which is both capable of regulating energy metabolism and being a target for it. Glutamine is the most bountiful and flexible amino acid in the body which provides adenosine 5′-triphosphate (ATP) demands for cells. Emerging evidences support that glutamine which acts as the second metabolic regulator after glucose exerts crucial roles in bone homeostasis at cellular level, including the lineage allocation and proliferation of bone mesenchymal stem cells (BMSCs), the matrix mineralization of osteoblasts, and the biosynthesis in chondrocytes. The integrated mechanism consisting of WNT, mammalian target of rapamycin (mTOR), and reactive oxygen species (ROS) signaling pathway in a glutamine-dependent pattern is responsible to regulate the complex intrinsic biological process, despite more extensive molecules are deserved to be elucidated in glutamine metabolism further. Indeed, dysfunctional glutamine metabolism enhances the development of degenerative bone diseases, such as osteoporosis and osteoarthritis, and glutamine or glutamine progenitor supplementation can partially restore bone defects which may promote treatment of bone diseases, although the mechanisms are not quite clear. In this review, we will summarize and update the latest research findings and clinical trials on the crucial regulatory roles of glutamine metabolism in BMSCs and BMSC-derived bone cells, also followed with the osteoclasts which are important in bone resorption.
Improving diagnosis and treatment of neuropathic pain in patients with cancer: The quality of national guidelines in Europe

In Europe, from 19 to 39% of the patients with cancer pain suffer from neuropathic pain. This pain is difficult to relieve and needs a specific management. To guide practitioners, clinical practice guidelines (CPGs) can be proposed. The aim of this thesis is 1) to assess the quality of development of these European CPGs, 2) to compare diagnosis and treatment between CPGs with their evidence and 3) to evaluate the applicability of these CPGs in practice. All European CPGs about the management of neuropathic cancer pain were collected and assessed with AGREE II instrument to evaluate the quality development. Each reference mentioned in CPGs was registered and each recommendation was compared between CPGs. A case vignette on neuropathic cancer pain was proposed to evaluate the applicability of CPGs. Nine CPGs met the criteria in Europe. Applicability, rigor of development and editorial independence were low. Only 18% of the references collected concerned cancer population. No consensus was found about the diagnosis. Six of the 9 CPGs extrapolated results from non-cancer to cancer patients without reservations. Only 54% of the French pain specialists diagnosed and treated neuropathic pain in a case vignette on cancer. We advise more international central cooperation (clinicians and methodologists) for the development of a European CPG on neuropathic pain in cancer patients: it would help to pool resources into a high quality guideline module.
Financial Structure and Economic Growth Nexus Revisited

Abstract This paper empirically reassesses the long-debated relationship between the financial structure and economic growth. Specifically, we examine whether the effect of financial structure on economic growth is affected by the occurrence of banking crisis and economic volatility, the level of financial development, and the financial structure disproportion. We employ the generalized method of moments estimation to a panel of 99 countries over the 1971–2015 period. Although the main result supports the market-based view, the positive effect of the securities market development relative to the banking system weakens significantly if the financial structure is unbalanced. Our findings are robust to a variety of sensitivity checks, including different measures of financial structure, time periods, and model specifications.
Issues, benefits and challenges of original cataloguing versus copy cataloguing: The experience at the Lagos State University

Copy catalogue has long been underutilized. Plagued by insufficient bibliographic control throughout most of the twentieth century, information resource centers especially the library have started to use Online Computer Library Center (OCLCs) a standard bibliographic rules. However, through a piecemeal effort, many bibliographic records have been entered into OCLCs by a number of libraries. In this study, descriptive survey method was adopted; the target population is all cataloguers who are currently serving or have served in the cataloguing section of the Lagos State University (LASU) library. Sample consisted of thirty-seven (37) cataloguers purposively selected. Questionnaire was used to collect data; major findings from the study reveal that there is a remarkable change in copy catalogue over original catalogue practices among cataloguers under study. The study also revealed that funding is a major challenge confronting Lagos State University library. Key words: Original cataloguing, copy cataloguing, bibliographic records, metadata, online computer library center (OCLC), Lagos State University Library.
Four targeted genes for predicting the prognosis of colorectal cancer: A bioinformatics analysis case

The molecular mechanisms underlying the development and progression of colorectal cancer (CRC) have not been clarified. The purpose of the present study was to identify key genes that may serve as novel therapeutic targets or prognostic predictors in patients with CRC using bioinformatics analysis. Four gene expression datasets were downloaded from the Gene Expression Omnibus database, which revealed 19 upregulated and 34 downregulated differentially expressed genes (DEGs). The downregulated DEGs were significantly enriched in eight pathways according to Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis. A protein-protein interaction network was constructed with 52 DEGs and 458 edges. Ten key genes were identified according to the degree value, betweenness centrality and closeness centrality. Survival analysis revealed that low expression of four of the ten genes, carcinoembryonic antigen related cell adhesion molecule 7 (CEACAM7), solute carrier family 4 member 4 (SLC4A4), glucagon (GCG) and chloride channel accessory 1 (CLCA1) genes, were associated with unfavorable prognosis in CRC. Furthermore, gene set enrichment analysis revealed that two pathways were significantly enriched in the CEACAM7 low-expression group. Thus, CEACAM7, SLC4A4, GCG and CLCA1 may be prognostic markers or therapeutic targets of CRC. Low CEACAM7 expression may be associated with the activation of glycosaminoglycan biosynthesis-chondroitin sulfate and extracellular matrix receptor interaction pathways and may affect the prognosis of CRC.
Minding the Baby: The challenges of implementing a reflective functioning programme with high-risk families

Part 1: Literature Review: This section consists of a meta-analytic review examining the efficacy of video-feedback interventions aimed at promoting parental sensitivity and infant attachment. Outcomes from 18 RCTs contributing 20 intervention effects were examined. Results indicated that video-feedback interventions are efficacious in promoting parental sensitivity, infant attachment security and preventing infant attachment disorganisation. These findings suggest that video-feedback interventions may offer exciting potential for clinical practice. Part 2: Empirical Paper: The empirical paper reports on a qualitative study examining the challenges of implementing ‘Minding the Baby’ (MTB), a preventative parenting programme developed explicitly to promote secure parent-child attachment relationships. Semi-structured interviews were conducted with 13 practitioners delivering the programme. Transcripts were analysed thematically and themes were organised into two domains relating to the challenges of implementation and the components of MTB which practitioners identified as being crucial in engaging mothers in reflective work. Results highlight the importance of designing and delivering services which support mentalisation throughout. In addition, a strong therapeutic relationship was identified to be crucial in engaging mothers in reflective work and in responding to the challenges of implementing a mentalisation-based parenting intervention. The study was conducted in collaboration with another UCL Clinical Psychology doctoral student, whose thesis examines parents’ experiences of the therapeutic process in MTB (Burns, 2014).
THE IMPACT OF SERVICE QUALITY ON CUSTOMER LOYALTY WITH MODERATING EFFECT OF CUSTOMER SATISFACTION IN DITLANTAS POLDA NTB

The purpose of this study are: to determine the significance impact of the Quality Service on Customer Loyalty; to determine the significance impact of Quality Service on customer loyalty through moderation of Customer Satisfaction at Ditlantas Polda NTB. The research method is a causal research. The data collection is done by using questionnaires given to 150 respondents. The analysis of data is using Moderated Regression Analysis (MRA). The result showed that (1) Quality Service has a positive and significant impact on Customer Loyalty, (2) Quality Service has a significant impact on Customer Loyalty through moderation of Customer Satisfaction at Ditlantas Polda NTB. Researcher recommended to policy holders to take attention on the Quality Service and the level of Customer Satisfaction about the product. Quality Service could be increased by upgrading resources to new technology, involving BABINKAMTIBMAS and also socialization to school around NTB province, this method seems to be very effective because it could be touched people directly. Ditlantas Polda NTB needs to start utilizing print and electronic media to introduce their product with the principle of regulation and law which exist in Indonesia so that customers could know and understand the products well.