Miracle-dz/UniFAR-FTUs huggingface dataset:
High prevalence of mixed genotype infections in hepatitis B virus infected intravenous drug users

The clinical relevance of hepatitis B virus (HBV) genotypes has been documented; however, the prevalence of mixed HBV genotype infections in at‐risk groups remains controversial. The HBV genotypes were determined in 325 HBV‐infected intravenous drug users (IVDU) who were at a greater risk of multiple exposures to different HBV genotypes by using a newly developed line probe assay. The distribution of HBV genotype was as follows: genotype A alone in 2 (0.6%); genotype B alone in 256 (78.8%); genotype C alone in 10 (3.1%); mixed genotype A and B in 18 (5.5%); genotype B and C in 30 (9.2%); genotype B and D in 1 (0.3%); genotype A and C in 1 (0.3%); and mixed infections of genotype A, B, and C in 3 (0.9%). Clonal analysis confirmed further the existence of mixed genotype infection and recombination between different genotypes. Compared with our previous data, the line probe assay seemed more sensitive than polymerase chain reaction (PCR)‐restriction fragment length polymorphism (RFLP) assay in identifying HBV genotype (98.8% vs. 65.0%) and detecting mixed genotype infections (16.3% vs. 0%). In conclusion, the prevalence of mixed HBV infections is substantially higher in IVDU in endemic areas, and the line probe assay is a useful method for rapid genotyping of HBV, with particular reference to the detection of mixed genotype infections. J. Med. Virol. 74:536–542, 2004. © 2004 Wiley‐Liss, Inc.
The Global Dimension of Inflation – Evidence from Factor‐Augmented Phillips Curves

We examine the global dimension of inflation in 24 OECD countries between 1980 and 2007 in a traditional Phillips curve framework. We decompose output gaps and changes in unit labor costs into common (or global) and idiosyncratic components using a factor analysis and introduce these components separately in the regression. Unlike previous studies, we allow global forces to affect inflation through (the common part of) domestic demand and supply conditions. Our most important result is that the common component of changes in unit labor costs notably affects inflation. We also find evidence that movements in import price inflation have small effects on CPI inflation while the impact of movements in the common component of the output gap is unclear. A counterfactual experiment illustrates that the common component of unit labor cost changes and non-commodity import price inflation have held down overall inflation in many countries in recent years. Our results imply that monetary policy makers need to carefully monitor global forces when assessing and predicting inflation. In analogy to the Phillips curves, we estimate monetary policy rules with common and idiosyncratic components of inflation and the output gap included separately. Central banks have indeed reacted to the global components.
ZONE‐TARGETING MONETARY POLICY PREFERENCES AND FINANCIAL MARKET CONDITIONS: A FLEXIBLE NON‐LINEAR POLICY REACTION FUNCTION OF THE SARB MONETARY POLICY

Based on a representation of policymaker’s preferences that capture inflation zone targeting behaviors, we estimate a flexible model of the monetary policy reaction function of the South African Reserve Bank (SARB). To address the current debate on the importance of financial asset prices in monetary policy decision making, we augment the analysis to allow for responses to financial market conditions over and above prices and output stabilisation. The main findings are that the monetary authorities’ response towards inflation is zone symmetric. Secondly, the monetary authorities’ response towards output is asymmetric with increased reaction during business cycle downturns versus upturns. Thirdly, the monetary authorities’ pay close attention to financial conditions index. They place the same weight on financial market booms and recessions so that their response is symmetric.
Teacher Preparedness for a Changing Demographic of Language Learners

English-language learners (ELLs) are becoming common in classrooms with Ontario’s escalating immigration trends. Elementary school teachers are increasingly becoming responsible for meeting the needs of linguistically diverse children. This qualitative study explores current teacher preparation practices through preservice teachers’ (PT) perspectives and explores how prepared primary-junior PTs are to teach ELLs in southwestern Ontario. Through a structured interview, six certified graduates shared descriptive experiences, knowledge, and beliefs. Findings indicate that although moving toward greater ELL awareness and inclusive mindsets, there is evidence that well-intentioned teachers lack the competence necessary for effective classroom practice.
Inactivation of transmissible degenerative encephalopathy agents: A review.

The unconventional agents that cause transmissible degenerative encephalopathies, such as bovine spongiform encephalopathy, scrapie, and Creutzfeldt-Jakob disease (CJD), are relatively resistant to inactivation by standard decontamination procedures. The only methods that appear to be completely effective under worst-case conditions are strong sodium hypochlorite solutions or hot solutions of sodium hydroxide. Other procedures that result in significant degrees of inactivation are described. The infectivity levels in histologically-fixed tissue can be reduced substantially by treatment with concentrated formic acid without adversely affecting the microscopic quality of the tissue.
Diagnosing cultural barriers to knowledge management

Executive Overview Organizational culture is increasingly recognized as a major barrier to leveraging intellectual assets. This article identifies four ways in which culture influences the behaviors central to knowledge creation, sharing, and use. First, culture—and particularly subcultures—shape assumptions about what knowledge is and which knowledge is worth managing. Second, culture defines the relationships between individual and organizational knowledge, determining who is expected to control specific knowledge, as well as who must share it and who can hoard it. Third, culture creates the context for social interaction that determines how knowledge will be used in particular situations. Fourth, culture shapes the processes by which new knowledge—with its accompanying uncertainties—is created, legitimated, and distributed in organizations. These four perspectives suggest specific actions managers can take to assess the different aspects of culture most likely to influence knowledge-related behaviors.
Heligmosomoides polygyrus inhibits established colitis in IL‐10‐deficient mice

Inflammatory bowel disease (IBD) is prevalent in industrialized countries, but rare in less‐developed countries. Helminths, common in less‐developed countries, may induce immunoregulatory circuits protective against IBD. IL‐10–/– mice given piroxicam develop severe and persistent colitis. Lamina propria mononuclear cells from colitic IL‐10–/– mice released IFN‐γ and IL‐12. The ongoing piroxicam‐induced colitis could be partially blocked with anti‐IL‐12 monoclonal antibody suggesting that the inflammation was at least partly IL‐12 dependent. Colonization of piroxicam‐treated colitic IL‐10–/– mice with Heligmosomoides polygyrus (an intestinal helminth) suppressed established inflammation and inhibited mucosal IL‐12 and IFN‐γ production. H. polygyrus augmented mucosal IL‐13, but not IL‐4 or IL‐5 production. Transfer of mesenteric lymph node (MLN) T cells from IL‐10–/– animals harboring H. polygyrus into colitic IL‐10–/– recipients inhibited colitis. MLN T cells from worm‐free mice did not. Foxp3 (scurfin) drives regulatory T cell function. H. polygyrus enhanced Foxp3 mRNA expression in MLN T cells that had regulatory activity. This suggests that H. polygyrus inhibits ongoing IL‐10–/– colitis in part through blocking mucosal Th1 cytokine production. Resolution of inflammation is associated with increased IL‐13 production and can be adoptively transferred by MLN T cells.
Ontario's Principal Scarcity: Yesterday's Abdicated Policy Responsibility—Today's Unrecognised Challenge

This article highlights the principal recruitment problem in Ontario. It suggests that the problem is closely associated with the retirement plans of principals which is resulting in a significant loss of human capital; poorly planned implementation of policy changes which presents problems at the school level and discourages potential leaders from pursuing the principalship; and a lengthy and burdensome certification process. The article concludes that leadership succession planning and development in Ontario represents a major policy challenge to government and school boards alike.
Where on Earth is Everybody? The Evolution of Global Bilateral Migration 1960-2000

Global matrices of bilateral migrant stocks spanning 1960-2000 are presented, disaggregated by gender and based primarily on the foreign-born definition of migrants. More than one thousand census and population register records are combined to construct decennial matrices corresponding to the five census rounds between 1960 and 2000. For the first time, a comprehensive picture of bilateral global migration over the second half of the 20th century emerges. The data reveal that the global migrant stock increased from 92 million in 1960 to 165 million in 2000. Quantitatively, migration between developing countries dominates, constituting half of all international migration in 2000. When the partition of India and the dissolution of the Soviet Union are accounted for, migration between developing countries is remarkably stable over the period. Migration from developing to developed countries is the fastest growing component of international migration in both absolute and relative terms. The United States has remained the most important migrant destination in the world, home to one fifth of the world's migrants and the top destination for migrants from some 60 sending countries. Migration to Western Europe has come largely from elsewhere in Europe. The oil-rich Persian Gulf countries emerge as important destinations for migrants from the Middle East and North Africa and South and Southeast Asia. Finally, although the global migrant stock is predominantly male, the proportion of female migrants increased noticeably between 1960 and 2000. The number of women rose in every region except South Asia.
Determinants of ambulatory blood pressure response to physical activity

Objectives Previous studies reported that the association between physical activity, measured with a wrist-worn accelerometer, and ambulatory blood pressure is rather weak and that the inter-individual variation in the degree of association is high. The aim of the present study was to quantify the responses of ambulatory blood pressure (BP) and heart rate (HR) to physical activity, and to determine the effect of age, gender, body mass index, mean BP and HR level and the use of antihypertensive medication on these responses. Patients and methods Twenty-seven subjects (24 hypertensive) underwent 24-h ambulatory monitoring of BP, HR and physical activity. Physical activity was measured with four accelerometers mounted on the trunk and legs. The daytime BP and HR responses to physical activity and the possible modulating effects of the various subject characteristics on these responses were estimated with Random Regression Models. Results Increasing physical activity from a very low level (e.g. watching television) to a moderate level (e.g. shopping) caused an average response of systolic blood pressure (SBP) of 11.6 mmHg, of diastolic blood pressure (DBP) of 7.0 mmHg and of HR of 16.1 beats/min. The SBP response to activity was about 2 mmHg larger for the overweight subjects than for subjects with normal weight, and the SBP, DBP and HR responses increased about 0.8 mmHg, 0.6 mmHg and 0.7 beats/min, respectively, with every 10 years increase in age. The between-subjects variances in estimated responses were low and were almost completely explained by differences in overweight and age between subjects. The average within-subject variances, however, were high. Conclusions Normal daily physical activity explains only a small part of the BP and HR variability. The BP and HR responses to activity are modestly affected by age. Overweight has a small effect on the SBP response to activity.
Studies on essential oils: Part 10; Antibacterial activity of volatile oils of some spices

The essential oils extracted from the seeds of seven spices, Anethum graveolens, Carum capticum, Coriandrum sativum, Cuminum cyminum, Foeniculum vulgare, Pimpinella anisum and Seseli indicum have been studied for antibacterial activity against eight pathogenic bacteria, causing infections in the human body. It has been found that the oil of C. capticum is very effective against all tested bacteria. The oil of C. cyminum and A. graveolens also gave similar results. These oils are equally or more effective when compared with standard antibiotics, at a very low concentration. Copyright © 2002 John Wiley & Sons, Ltd.
Fertility parameters of dairy cows with cystic ovarian disease after treatment with gonadotrophin-releasing hormone

Fertility data were collected every four weeks for 10 years from 40 herds of Holstein-Friesian dairy cattle. The data collected during 925 lactations from cows with cystic ovarian disease which were treated with 500 μg gonadorelin were compared with data from a control group of 13,869 normal lactations. The intervals between parturition and first insemination and between parturition and conception were significantly shorter (P<0.001) in the normal cows, but the interval between first insemination and conception was not. The overall conception rate tended to be higher (P<0.10) in the normal cows, but the conception rate after the first insemination was significantly higher (P<0.001) and the number of services per conception was significantly lower (P=0.008) in the normal cows.
P53 and proliferating cell nuclear antigen (PCNA) expression in non‐tumoral liver diseases

The tumor suppressor gene p53 is known to be involved in the negative regulation of cell growth. Proliferating cell nuclear antigen (PCNA), which is a nuclear protein and a component of the DNA replication process, is also involved in growth regulation. Both have been studied as progression markers in various tumors including hepatocellular carcinoma. In the present study, the aberrant p53 protein and PCNA expressions in non‐tumoral liver diseases were investigated. Using monoclonal antibodies anti‐p53 (D07‐DAKO) and anti‐PCNA (PC10‐DAKO), 149 samples were stained, including 10 normal and 10 tumoral control liver tissues. p53 Overexpression was detected in 52 specimens (35%) whereas PCNA positivity was found in 96 (64%). There were 21 different pathological entities but most of the positive samples could be grouped into four types of diseases; namely, non‐specific reactive hepatitis, steatohepatitis, chronic hepatitis and cirrhosis. Statistical analyses performed on these groups revealed that p53 positivity was found to be significantly higher in steatohepatitis (P < 0.05), while PCNA positivity did not show any statistical significance. The number of samples showing both p53 and PCNA positivity was 42 but their coexistence was not found to be significant. Certain cytological alterations like nuclear pleomorphism, steatosis and cholestasis, in addition to necroinflammatory activity, were evaluated for their possible impact on p53 and/or PCNA positivity. Necroinflammatory activity in steatohepatitis and steatosis in chronic hepatitis was found to be significant for p53 positivity (P < 0.05). In contrast, nuclear pleomorphism in non‐specific reactive hepatitis was found to be significant for PCNA positivity (P < 0.05).
An Institutional Economic Analysis of Labor Unions

This paper uses institutional economic theory in the line of Commons and Coase to examine the purposes, economic effects, and social welfare consequences of labor unions. Cross‐discipline and cross‐national principles of the institutional paradigm are described, the American and European literatures are briefly juxtaposed, and the subject of unions is placed in a larger paradigm context. Relative to previous studies, this paper presents the most formal and analytically developed application of institutional theory to the subject of unions. A number of new or revisionist implications are developed, as are contrasts with neoclassical‐based models.
Sources of volatility during four oil price crashes

Abstract Previous sharp oil price declines have been accompanied by elevated ex-post volatility. In contrast, volatility was much less elevated during the oil price crash in 2014/15. We provide evidence that oil prices declined in a relatively measured manner during 2014/15, with a dispersion of price changes that was considerably smaller than comparable oil price declines. This finding is robust to using both descriptive and GARCH measures of volatility. Further, the US dollar appreciation exerted a strong influence on volatility during the recent crash; in contrast, the impact of equity market shocks was muted.
Technological leadership and sectorial employment growth: A spatial econometric analysis for U.S. counties

This paper investigates the determinants of technological catch-up and examines at a refined level of spatial and sectoral aggregation to what extent geographical and/or technological proximity to the technology leader impact regional employment growth. Technological progress is endogenously determined and depends on specialization, competition and diversity. We also allow technological progress to depend on agglomeration economies in proximate regions, and model technological progress by means of a hierarchical process of catch-up to the technology leader. Results indicate that human capital plays a crucial role in promoting sectoral employment growth. The effect of technological distance varies, depending on which sector is considered. Technological distance to the leader shows a positive and significant effect on employment growth in the sectors Construction & Manufacturing, Information & Utilities, and Services. No effect of technological distance was found for Finance & Management, Transportation & Trade, and Natural Resources. The effect of geographical distance to the technology leader on employment growth also varies across sectors. A negative effect is observed for Construction & Manufacturing and Finance & Management, while the effect is positive for Natural Resources and Transportation & Trade, and statistically not different from zero for Information and Utilities and Services.
External Auditor Evaluations of Outsourced Internal Auditors

SUMMARY: In the last decade internal auditing services has been a significant area of growth for public accounting firms. Unlike the provision of external audits, the provision of outsourced internal audit services does not prohibit accounting firms from providing the client with additional services. This study investigates some implications of an outsourced internal auditor providing nonaudit services. Specifically, 89 experienced external auditors completed an experiment to investigate whether external auditors will evaluate and rely on an outsourced internal auditor’s work differently when the internal auditor also provides nonaudit services. Results indicate that evaluations of the outsourced internal auditors’ objectivity were negatively affected by the provision of nonaudit services. Further, the differences in objectivity perceptions are tempered by the use of different personnel to provide consulting services. Competence perceptions were not affected. Results also indicate that external auditor re.
Will institutional reform enhance bilateral trade flows? Analyses from different reform aspects

This paper examines the effect of various types of institutional reforms in enhancing bilateral trade flows. We examine three types of institutional reforms – democratic political system, legal, and administrative reforms – and distinguish an initial effect from a permanent effect on bilateral trade. Using a panel of 62 countries over 1980–2008, we find that all three types of reforms are important in enhancing bilateral trade flows, but their positive effects are only observed when the reforms are permanent. Our study concludes that permanent improvement in domestic institutions should be an important objective for policy makers to pursue in promoting trade.
Audit Office Size, Audit Quality and Audit Pricing

SUMMARY: Using a large sample of U.S. audit client firms over the period 2000–2005, this paper investigates whether and how the size of a local practice office within an audit firm (hereafter, office size) is a significant, engagement-specific factor determining audit quality and audit fees over and beyond audit firm size at the national level and auditor industry leadership at the city or office level. For our empirical tests, audit quality is measured by unsigned abnormal accruals, and the office size is measured in two different ways: one based on the number of audit clients in each office and the other based on a total of audit fees earned by each office. Our results show that the office size has significantly positive relations with both audit quality and audit fees, even after controlling for national-level audit firm size and office-level industry expertise. These positive relations support the view that large local offices provide higher-quality audits compared with small local offices, and that s.
The Effect of Changes in State and Federal Policy For Nonprescription Access to Emergency Contraception On Youth Contraceptive Use: A Difference‐In‐Difference Analysis Across New England States

type="main" xml:id="coep12081-abs-0001"> One of the more contentious policy changes in the past decade in the United States involves the decisions by several state legislatures and the Food and Drug Administration (FDA) to permit sales of emergency contraception on a nonprescription basis. We took advantage of a set of natural experiments to estimate the impact of changes in state and federal level nonprescription emergency contraception access on the probability of high-school students' sexual and contraceptive behaviors. We extracted data from the Youth Risk Behavioral Survey for New England states that had data about contraceptive use (Maine, New Hampshire, Rhode Island, and Vermont) from 2003 to 2009. We combined this student-level data with information on when states and the FDA began allowing nonprescription sales of emergency contraceptives. We estimated a series of difference-in-difference models on the impact of these policies on the probability that students were sexually active and on the probability of condom or hormonal birth control use conditional on sexual activity. We found that switching emergency contraception to a nonprescription status had no systematic effect on the probability of sexual activity or the conditional probability of hormonal birth control use, but that it significantly reduced the probability that public school students used condoms by between 5.2% and 7.2% . ( JEL I18, I12, I29)