Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparison of FRAX in postmenopausal Asian women with and without type 2 diabetes mellitus: a retrospective observational study

Objective To compare the fracture risk in postmenopausal Asian women with or without type 2 diabetes mellitus (T2DM). Methods The study cohort comprised data from consecutive postmenopausal women with T2DM that were retrieved from a prospectively maintained institutional database from 2001 to 2009. Postmenopausal women without DM from the Medical Examination Center from 2001 to 2009 formed the control cohort. The primary endpoint was the World Health Organization Fracture Risk Algorithm (FRAX, revised 2013) score. The secondary endpoint was bone mineral density (BMD). Results There were 1014 individuals included for the assessment (T2DM, n=500 and non-DM, n=514). Based on the FRAX model, the risk of major osteoporotic fractures and hip fractures over the next 10 years was higher in the T2DM group compared with the non-DM group. Compared with the T2DM group, the non-DM group had a lower BMD. After adjusting for age, gender, history of alcohol consumption, smoking status, body mass index, and low-density lipoprotein, the differences were statistically significant. Conclusions Compared with postmenopausal women without DM, postmenopausal women with T2DM had a significantly higher fracture risk calculated using the FRAX model. Early intervention for postmenopausal women with T2DM may be necessary, although T2DM is associated with a high BMD.
A Comparative Analysis of Risk Perception and Coping Behaviors among Chinese Poultry Farmers Regarding Human and Poultry Infection with Avian Influenza

Poultry farmers face a dual risk when mutant avian influenza (AI) virus exhibits zoonotic characteristics. A/H5N1 and A/H7N9 are two principal strains of the AI virus that have captured public attention in recent years, as they have both been reported and can infect poultry and humans, respectively. Previous studies have focused either on poultry farmers’ risk perception and biosecurity preventive behaviors (BPBs) against A/H5N1 infection with poultry, or on their risk perception and personal protective behaviors (PPBs) against human infection with A/H7N9, even though these two strains often appear simultaneously. To bridge this research gap, a survey (N = 426) was conducted in the Chinese provinces of Jiangsu and Anhui to assess risk perception and coping behaviors adopted by poultry farmers facing the dual risk of these two viral strains. Paired sample t-tests revealed that farmers’ perceived risk of poultry infection with A/H5N1 was significantly higher than their perceived risk of human infection with A/H7N9, and that their reported frequency of BPBs against A/H5N1 was significantly higher than the frequency of PPBs against A/H7N9. Moreover, farmers were less familiar with AI infection in human beings compared to that in poultry, but they felt a higher sense of control regarding human AI infection. Multivariate regression analyses showed that farm size and perceived risks of both human and poultry infection with AI were positively associated with BPBs and PPBs. The findings of this research suggest that a campaign to spread knowledge about human AI infection among poultry farmers is needed, and that a policy incentive to encourage large-scale poultry farming could be effective in improving implementation of BPBs and PPBs.
Delay in schistosomiasis diagnosis and treatment: a multicenter cohortstudy in Italy.

BACKGROUND Barriers to access to care, different diagnostic strategies, and low awareness remain challenging issues in the fight against schistosomiasis.Our study aims to examine management of schistosomiasis in migrants attending large tertiary hospitals in Italy, in order to call for a comprehensive approach. METHODS A retrospective review of schistosomiasis cases was carried out between January 1, 2016 and December 31, 2017 in five large Infectious Disease Centers in Italy. We included all patients diagnosed with schistosomiasis. We differentiated among i) asymptomatic patients diagnosed by serology either as healthy 'migrant evaluation' or as 'late evaluation' in patients followed because of a different infection and ii) patients tested because of a suggestive clinical presentation. Patients characteristics and clinical data were recorded. RESULTS 149 patients were included, 137 (91.9%) were male, the median age was 26 years and 70% of them came from Sub-Saharan Africa.Thirty-eight asymptomatic patients (25.5%) were diagnosed by serology [15, (10.1%) among 'migrant evaluation' and 23 (15.4%) among 'late evaluation' group] and 111 (74.5%) presented with signs/symptoms.The median diagnostic delay from arrival in Italy was 31 months: 110 for asymptomatic group and 16 months for symptomatic patients. Among the 111 symptomatic patients, 41 individuals were already followed in our Clinics and they never underwent screening before appearance of evident disease. Among patients with positive serology who were tested by microscopy, 32/86 (37.2%) had confirmed diagnosis. Forty-five (37.8%) patients presented radiologic abnormalities. Praziquantel was the treatment of choice (70.1% for 3 days and 29.9% in a single-day dose) and 77 (51.7%) were lost to follow-up. CONCLUSION In our centers, a high proportion of patients were tested late after arrival and most of them presented with clinical apparent disease. Well-defined strategies and implementation of recent guidelines are needed to improve early diagnosis and to overcome heterogeneity of practice.
The Role of Sleep Duration and Sleep Problems During Childhood in the Development of ADHD in Adolescence: Findings From a Population-Based Birth Cohort

Objective: We aimed to investigate the association between sleep in early life and ADHD in adolescence. As a secondary analysis, we tested whether the associations may be specific to ADHD. Method: Data from 3,467 participants of the 2004 Pelotas Birth Cohort were used. Information on their sleep duration and problems was collected at 12, 24, and 48 months of age. ADHD diagnosis and hyperactivity/inattention problems were assessed with the Development and Well-Being Assessment (DAWBA) and the Strengths and Difficulties Questionnaire (SDQ) among participants at 11 years of age. Results: Difficulty going to sleep at 24 months, nightmares at 24 months and at 48 months, and restless sleep at 48 months were consistently associated with ADHD as well as with other mental disorders. Conclusion: The results suggest that sleep disturbances may be more important ADHD predictors than sleep duration or sleep duration trajectories. However, it may also be considered early markers of other mental disorders.
Emerging Roles of Lysyl Oxidases in the Cardiovascular System: New Concepts and Therapeutic Challenges

Lysyl oxidases (LOX and LOX-likes (LOXLs) isoenzymes) belong to a family of copper-dependent enzymes classically involved in the covalent cross-linking of collagen and elastin, a pivotal process that ensures extracellular matrix (ECM) stability and provides the tensile and elastic characteristics of connective tissues. Besides this structural role, in the last years, novel biological properties have been attributed to these enzymes, which can critically influence cardiovascular function. LOX and LOXLs control cell proliferation, migration, adhesion, differentiation, oxidative stress, and transcriptional regulation and, thereby, their dysregulation has been linked to a myriad of cardiovascular pathologies. Lysyl oxidase could modulate virtually all stages of the atherosclerotic process, from endothelial dysfunction and plaque progression to calcification and rupture of advanced and complicated plaques, and contributes to vascular stiffness in hypertension. The alteration of LOX/LOXLs expression underlies the development of other vascular pathologies characterized by a destructive remodeling of the ECM, such as aneurysm and artery dissections, and contributes to the adverse myocardial remodeling and dysfunction in hypertension, myocardial infarction, and obesity. This review examines the most recent advances in the study of LOX and LOXLs biology and their pathophysiological role in cardiovascular diseases with special emphasis on their potential as therapeutic targets.
Nucleation and Growth of Amino-acid and Peptide Supramolecular Polymers through Liquid-liquid Phase Separation.

The transition of peptides and proteins from solution into fibrillar structures is a general phenomenon encountered in functional and aberrant biology and is increasingly exploited in soft materials science. However, the fundamental molecular events underpinning the early stages of their assembly and subsequent growth have remained challenging to elucidate. Here, we show that liquid-liquid phase separation into solute-rich and solute-poor phases is a fundamental step leading to the nucleation of supramolecular nanofibrils from molecular building blocks, including peptides and even amphiphilic amino acids. The solute-rich liquid droplets act as nucleation sites, allowing the formation of thermodynamically favorable nanofibrils following Ostwald's step rule. The solution to liquid droplets transition is entropy driven while the liquid droplets to nanofibrils transition is mediated by enthalpic interactions and characterized by structural reorganization. These findings shed light on how the nucleation barrier toward the formation of solid phases can be lowered through a kinetic mechanism which proceeds through a metastable liquid phase.
Consumer beliefs about healthy foods and diets

Background The U.S. Food and Drug Administration has begun a public process to redefine how companies are allowed to use the term “healthy” on food packages. Although the definition is formulated based on the latest consensus in nutrition and epidemiological research, it is also important to understand how consumers define and understand the term if it is to be behaviorally relevant. This research is an exploratory study designed to provide a descriptive account of consumers’ perceptions of and beliefs about the meaning of “healthy” food. Methods A nationwide U.S. sample of 1,290 food consumers was surveyed in December 2018. Respondents answered 15 questions designed to gauge perceptions of healthy food and to elicit preference for policies surrounding healthy food definitions. Responses are weighted to demographically match the population. Categorical variables have a sampling error of ±2.7%. Exploratory factor analysis is used to determine latent dimensions of health perceptions related to food type. Results Consumers were about evenly split on whether a food can be deemed healthy based solely on the foods’ nutritional content (52.1% believing as such) or whether there were other factors that affect whether a food is healthy (47.9% believing as such). Consumers were also about evenly split on whether an individual food can be considered healthy (believed by 47.9%) or whether this healthiness is instead a characteristic of one’s overall diet (believed by 52.1%). Ratings of individual food products revealed that “healthy” perceptions are comprised of at least three underlying latent dimensions related to animal origin, preservation, and freshness/processing. Focusing on individual macronutrients, perceived healthiness was generally decreasing in a food’s fat, sodium, and carbohydrate content and increasing in protein content. About 40% of consumers thought a healthy label implied they should increase consumption of the type of food bearing the label and about 15% thought the label meant they could eat all they wanted. Conclusions Results suggest consumer’s perceptions of “healthy,” which is primarily based on fat content, partially aligns with the FDA definition but also suggest consumers perceive the word as a broader and more nuanced concept that defies easy, uniform definition. Results highlight areas where nutrition education may be needed and suggest disclosures may need to accompany health claims so that consumers know what, precisely, is being communicated.
Elevated serum procalcitonin level in patients with chronic kidney disease without infection: A case‐control study

Inflammation is a necessary component of chronic kidney disease (CKD) that can be attributed to an accumulation of toxins and a reduced clearance of proinflammatory cytokines. Procalcitonin (PCT) is a widely applied biomarker in the diagnosis of infection, and considering the presence of pre‐existing inflammation in CKD patients, the PCT level could be high in such a population; however, no reference value for PCT in CKD patients has been available to date.
Public health impact of coal-fired power plants: a critical systematic review of the epidemiological literature

ABSTRACT Coal-based energy production is the most utilized method of electricity production worldwide and releases the highest concentration of gaseous, particulate, and metallic pollutants. Toxicological research has shown that coal combustion by-products are carcinogens, endocrine disruptors, and cardiorespiratory toxins. This article aims to systematically review the epidemiological literature on the impact emissions from coal-based power production has on morbidity and mortality worldwide. Two thousand one hundred and fifty-two articles were retrieved based on search criteria. Word search of abstract and article text filtered the results to 95 articles. Forty articles were included after screening. The literature indicates a significant adverse effect from particulate matter and polyaromatic hydrocarbon emissions on morbidity and mortality. There is a lack of consistency of exposure assessment and inadequate control of significant potential confounders such as social economic status. Future research should focus on improving exposure assessment models, specifically source-apportionment and geographic information system methods to model power plant-specific emissions.
Monitoring liver transplant rates in persons diagnosed with hepatitis C: a data linkage study, England 2008 to 2017

Introduction Liver transplantation is an important measure of burden from hepatitis C virus (HCV)-associated liver disease. Aims To describe transplant rates and survival in individuals with HCV infection from 2008 to 2017 in England through data linkage. Methods This is a retrospective observational cohort study. Laboratory reports of HCV infection were linked to the Liver Transplant Registry for individuals aged 15 years and over, first diagnosed between 1998 and 2017. We estimated age-sex standardised incidence rates and used Poisson regression to investigate predictors of liver transplantation and test for a change in incidence after introduction of direct-acting antivirals (DAAs) in 2014. Kaplan-Meier survival analysis was used to calculate post-transplant survival rates. Results Of 124,238 individuals diagnosed with HCV infection, 1,480 were registered and 1,217 received a liver transplant. Of individuals registered, 1,395 had post-HCV cirrhosis and 636 had hepatocellular carcinoma (618 also had post-HCV cirrhosis). Median time from HCV diagnosis to transplant was 3.4 years (interquartile range: 1.3–6.8 years). Liver transplant rates were lower 2014–17 compared with 2011–13 (incidence rate ratio: 0.64; 95% confidence interval: 0.55–0.76). Survival rates were 93.4%, 79.9% and 67.9% at 1, 5 and 10 years, respectively. Data linkage showed minimal under-reporting of HCV in the transplant registry. Conclusion In the post-DAA era, liver transplant rates have fallen in individuals with HCV infection, showing early impact of HCV treatment scale-up; but the short time from HCV diagnosis to liver transplant suggests late diagnosis is a problem.
Handwashing Behavior Change at Scale: Evidence from a Randomized Evaluation in Vietnam

This brief summarizes the results of a gender impact evaluation study, entitled Hand washing behavior change at scale : evidence from a randomized evaluation in Vietnam, conducted in 2010 in Vietnam. The study evaluates a large-scale hand washing campaign in three provinces of Vietnam on the household level. The program did not have an impact on hand washing with soap behavior. Knowledge about the correct way to wash was high at baseline, and some areas of knowledge improved, but it did not have an impact on the already high access to soap within households and modest effects on the self-reported hand washing behavior of mothers. Observed hand washing behaviors remained very low; mostly caregivers wash their hands with water only. Funding for the study derived from the Bill and Melinda Gates Foundation.
Statistical modeling, Sobol sensitivity analysis and optimization of single-tip tool geometrical parameters in the cortical bone machining process

Machining and cutting of cortical bones are very common and important in the field of orthopedic surgeries. Considerable advances in bone machining are obtained by using computer numerical control machines and automatic surgery robots but still, researches are needed to investigate the effects of machining parameters in bone machining. In this article, for the first time, the effect of geometrical parameters of the single-tip tool on cortical bone machining is studied. The machining parameters included in the investigation are rake angle, back rake angle and side cutting edge angle and the response surface methodology is used to analyze the obtained surface quality according to a second-order regression model. The sensitivity of surface quality to the input parameters was measured by applying Sobol sensitivity analysis and the results are optimized by the Derringer algorithm. Finally, the optimum tool is determined as 15° rake angle, −5° back rake angle and 30° side cutting edge angle. Furthermore, the sensitivity of the surface quality to the input parameters is determined as 52% for rake angle, 31% for side cutting edge angle and 17% for back rake angle.
Scenario Modeling of Urbanization Development and Water Scarcity Based on System Dynamics: A Case Study of Beijing–Tianjin–Hebei Urban Agglomeration, China

Due to the accelerated process of urbanization in China, urban agglomerations have become the core areas for human settlement and economic development. High population and economic density has brought great pressure on water supply. Water scarcity is increasingly becoming one of the most important issues for the sustainable and healthy development of China’s urban agglomerations. In this paper, a system dynamics model was constructed to simulate the current conditions and future scenarios of urbanization development and water scarcity in the Beijing–Tianjin–Hebei (BTH) urban agglomeration in 2000–2030, by examining the interaction and feedback between the six major subsystems: water supply, water demand, water pollution, population urbanization, economic urbanization, and land urbanization. It is found that the South-to-North Water Diversion Project and the improved Reclaimed Water Reuse System may greatly increase the water supply. However, the speed of population urbanization and economic growth, the spatial structure of urban agglomeration and the water consumption pattern may determine the water demand. Although all scenarios may risk water scarcity in the future at some point, we could detect a comprehensive and relatively rational scenario to balance water scarcity, regional equity, and efficiency. It might help to synthetically understand the coordinated development mode between urbanization and water resources in Beijing–Tianjin–Hebei (BTH) urban agglomeration, and provide a useful analytical and decision support tool for scientists and policy-makers to achieve the sustainable urbanization development and water resource management.
Systematic revision of the Tubifera casparyi–T. dictyoderma complex: Resurrection of the genus Siphoptychium and introduction of the new genus Thecotubifera

ABSTRACT The genus Siphoptychium is resurrected on the basis of comparative morphology and phylogeny of partial nuc 18S rDNA (18S) and translation elongation factor 1-alpha (EF1A) nucleotide sequences. The genus is characterized by the firm upper surface of the pseudoaethalium, accreted but easily separable sporothecae, a tubular or fibrous columella, and spores with a reticulate ornamentation consisting of 7–9 meshes across the diameter. In addition to the currently known single species S. casparyi (= Tubifera casparyi), two new members of Siphoptychium are described: S. violaceum from coniferous forests of Europe, east Asia, and southeast Asia, and S. reticulatum from temperate and subarctic regions of North America and alpine regions of Europe. A second genus, Thecotubifera, is described to accommodate Tubifera dictyoderma. The fruiting body of this species is transitional between a pseudoaethalium and a true aethalium. It is covered by a contiguous membranous cortex formed by the fused tips of the sporothecae, a feature typical for aethalia. However, the inner portions of sporothecae remain discernible, a feature more typical for pseudoaethalia. Columellae of Th. dictyoderma are formed by perforated plates, and the spores have a reticulate ornamentation consisting of 2–5 meshes across the diameter. For Th. dictyoderma, we could confirm records only for tropical regions and Japan, whereas all studied European specimens, including those mentioned in current monographs, represent species of Siphoptychium.
Quality Management and Formalization in Social Service Organizations - A Survey on Home-Based Family Intervention Services

Although the effects of quality management on social work are still widely unexplored, critics suspect that it will lead to a negative standardization of working conditions, whereas supporters of quality management hope for a greater transparency and effectiveness of service delivery. This article reports on a survey of 30 managers, 261 professionals, and 435 families in 30 family intervention service organizations. It uses cluster analysis to explore the relationship between quality management and different forms of work formalization. Results showed that working conditions generally are enabling for professional practice, but differences exist between what is called here a managerialist machine bureaucracy, an atomistic professional organization, and a collegiate professional organization.
Epigenetic Profiling Identifies LIF as a Super-enhancer-Controlled Regulator of Stem Cell–like Properties in Osteosarcoma

Osteosarcoma is an aggressive malignancy with poor prognosis. Super-enhancers (SE) have been highlighted as critical oncogenic elements required for maintaining the cancer cell characteristics. However, the regulatory role of SEs in osteosarcoma properties has not yet been elucidated. In the current study, we found that osteosarcoma cells and clinical specimens shared a significant fraction of SEs. Moreover, leukemia-inhibitory factor (LIF) was identified as an essential factor under the control of osteosarcoma-specific SE. The expression of LIF was positively correlated with the stem cell core factor genes in osteosarcoma. Furthermore, LIF recombinant protein–treated osteosarcoma cells displayed enhanced stem cell–like characteristics, such as increased sphere-forming potential, stimulated self-renewal, upregulated metastasis ability, and increased stemness-related gene expression. Notably, the histone 3 lysine 27 tri-methylation (H3K27me3) demethylase UTX was found as a key activator of LIF transcription in osteosarcoma. The UTX inhibitor, GSK-J4, induced H3K27me3 accumulation and impaired histone 3 lysine 27 acetylation (H3K27ac) at LIF gene locus, leading to LIF signaling pathway inhibition. GSK-J4 treatment resulted in profound defects in stem cell-like characteristics and stemness-related gene activation in osteosarcoma by modulating the H3K27ac of NOTCH1 signaling pathway gene loci. The NOTCH1 inhibitor Crenigacestat (TargetMol, T3633) repressed LIF-mediated activation of the stemness-related genes in osteosarcoma patient-derived primary tissues. Implications: This study reveals osteosarcoma SE profiles and uncovers a distinct tumor–stemness epigenetic regulatory mechanism in which an osteosarcoma-specific SE-mediated factor, LIF, promotes osteosarcoma stemness gene activation via NOTCH1 signaling pathway.