Miracle-dz/UniFAR-FTUs huggingface dataset:
Hydrological time series forecast model based on wavelet de-noising and ARIMA-LSTM

Hydrological time series is affected by many factors and it is difficult to be forecasted accurately by traditional forecast models. In this paper, a hydrological time series forecast model based on wavelet de-noising and ARIMA-LSTM is proposed. The model first removes the interference factors in the hydrological time series by wavelet de-noising, and then uses ARIMA model to fit and forecast the de-noised data to obtain the fitting residuals and forecast results. Then we use the residuals to train LSTM network. Next, the forecast error of the ARIMA model is forecasted by LSTM network and used to correct the forecast result of ARIMA model. In this paper, we use the daily average water level time series of a hydrological station in Chuhe River Basin as the experimental data and compare this model with ARIMA model, LSTM network and BP-ANN-ARIMA model. Experiment shows that this model can be well adapted to the hydrological time series forecast and has the best forecast effect.
Effects of tacrine, velnacrine (HP029), suronacrine (HP128), and 3,4‐diaminopyridine on skeletal neuromuscular transmission in vitro

1 The effects of tacrine (9‐amino‐1,2,3,4‐tetrahydroacridine), velnacrine (HP029, 9‐amino‐1,2,3,4‐tetrahydroacridin‐1‐ol maleate), suronacrine (HP128, 9‐benzylamino‐1,2,3,4‐tetrahydroacridin‐1‐ol maleate), and 3,4‐diaminopyridine on neuromuscular transmission were compared on isolated nerve‐muscle preparations. 2 Tacrine, HP029, and 3,4‐diaminopyridine augmented responses of chick biventer cervicis preparations to nerve stimulation, with tacrine and HP029 increasing responses to exogenously applied acetylcholine. HP128 blocked responses to nerve stimulation and to carbachol, but increased responses to acetylcholine. 3 In mouse diaphragm preparations that were partially paralysed by tubocurarine or low calcium solutions, tacrine, HP029, and 3,4‐diaminopyridine reversed the twitch block. HP128 deepened the block. 4 In mouse triangularis sterni preparations, tacrine and HP029 prolonged the decay phase of endplate potentials and miniature endplate potentials, but had no effect on quantal content at 36°C; above 10 μm, they reduced endplate potential amplitude. 3,4‐Diaminopyridine increased quantal content without affecting the time course of the endplate potentials. HP128 (1–10 μm) had no effect on amplitude or time course of endplate potentials, but reduced their amplitude at higher concentrations. 5 Extracellular recording of nerve terminal currents from triangularis sterni preparations revealed that 3,4‐diaminopyridine and HP128 had a selective blocking action on the waveform associated with K+ currents, tacrine reduced and prolonged the K+‐related waveform, and HP029 had nonselective blocking actions only seen at high concentrations. 6 Tacrine and HP029 behave predominantly as anticholinesterase agents, while HP128 has weaker anticholinesterase actions that are masked by cholinoceptor blockade. Tacrine and HP128, but not HP029, have some blocking actions on K+ currents of mouse motor nerve terminals.
Follicular miniaturization in female pattern hair loss: clinicopathological correlations

Background The pathology of female pattern hair loss (FPHL) is characterized by an increase in the proportion of vellus follicles, manifest as a low terminal/vellus ratio. This is conventionally thought to be due to a progressive miniaturization of terminal hair follicles. There is also a prolongation of the latent period of the hair cycle (kenogen) in both male pattern hair loss and FPHL and follicles in kenogen may be difficult to classify histologically. Therefore, a low terminal/vellus ratio could be due to a preferential increase in the number of terminal follicles in kenogen rather than to a true increase in the number of vellus follicles.
Exploiting Transmission and Caching Diversity in Cache-Enabled User-Centric Network: Analysis and Optimization

User-centric network (UCN) organizes a dynamic base station group (BSG) for each user equipment (UE), consisting of potential base stations (BSs) with caching ability. However, the performance gain brought by the increased BS diversity of potential BSs has not yet been analyzed. Using stochastic geometry, the analytical expression of average outage probability is derived for the cache-enabled UCN, where a practical scenario is considered wherein inter-cache data transfer cannot be performed between BSs and the serving BS must have the requested content. Specifically, the gain of BS diversity within the BSG is characterized, where the UE benefits from transmission resource diversity of the BSG by always connecting to the BS with the best coverage performance among those with the required content, and the increased caching content diversity is utilized by searching the content within the BSG. Based on the analysis, to minimize the lower bound of outage probability, closed-form optimal caching distribution is obtained which is more uniform than the request distribution. Outage probability of the cache-enabled UCN is decreased by 42.1% compared to the case where the UE connects to the nearest BS with the required content. Moreover, the optimal caching distribution decreases outage probability by 28.5% compared to the policy of caching the most popular contents.
On the Influence of Certain Natural Factors on the Sperm Quality and Sexual Behaviour of Rams

— In the Northern hemisphere, sheep reproduction is seasonal (September-November). Among several natural factors influencing the reproduction status of rams, we studied the daylight length and temperature. Rams from different breeds were studied: Merinos de Palas (half-precocious), Karakul de Botosani (half-belated) and Turcana (belated breed, low reproductive plasticity). In Merinos de Palas, ejaculate volume during sexual repose is 51.3% from normal quantity. When autumn climate was experimentally induced, ejaculate volume reached 98.45% (Merinos), 94.97% (Karakul) and 97.59% (Turcana). Semen density increased from 1.031-1.033 till 1.035 after exposition to artificial light and temperature conditions. Spermatozoids mobility and sperm pH improved, passing over 82% and 6.75, values identical to those in the natural reproduction season. Behaviour analysis after photoperiodicity indicated that over 83.3% Merinos and Karakul males and all Turcana rams exteriorised normal and intense sexual reflexes. Certain effort and reduced expenses brought rams in good condition, producing higher quantity and quality sperm.
Maternal and fetal outcome after invasive cervical cancer in pregnancy.

Invasive carcinoma of the cervix is the most common gynecologic malignancy to occur during the reproductive years. To analyze the effects of pregnancy on the course and survival of invasive cervical cancer, we compared 40 women with invasive cervical cancer to 89 nonpregnant controls matched for age, calendric year of diagnosis, stage, and tumor type. Additionally, we compared the distribution of invasive cervical cancer stages among the 40 pregnant women with that among the 1,963 cases of invasive cervical cancer treated during the same 30 years in women less than 45 years of age registered in the same hospital. To evaluate pregnancy outcome, we compared babies born to women with invasive cervical cancer to babies born of women matched for maternal age and not exposed to known teratogens or reproductive risks during pregnancy. Thirty-year survival of pregnant women with invasive cervical cancer was identical to that of their matched controls. Women having invasive cervical cancer were 3.1 times more likely to be diagnosed with stage I disease (95% confidence interval, 1.6 to 6.2). Additionally, they had a significantly lower chance of being diagnosed with stages III and IV (P = .02). Babies born to women with invasive cervical cancer were similar in gestational age and rates of prematurity but had a lower birth weight than the matched controls. There were two stillbirths among the 24 pregnancies that continued to term (8%), not statistically different from the 1.1% rate for Ontario. Our data suggest that pregnancy per se does not adversely affect the survival of women with invasive cervical cancer. However, this study provides evidence that pregnant women are more likely to present with early disease because of regular, pregnancy-related obstetric exams. Moreover, there is an increased risk for stillbirth, which should lead to follow-up of these patients by a high-risk perinatal unit.
A Reconstructing Method of PSWF Pulse Based on Three-valued Walsh Interpolation Functions

Aiming at the problems that currently obtaining prolate spheroidal wave functions (PSWF) is large amount of computation, poor real-time performance, high hardware cost, and low storage efficiency, this paper first studies the reconstructing method of PSWF pulse based on Walsh function system. Secondly, using Walsh function interpolation theory and generalized Walsh function system theory, a reconstruction method of PSWF pulse based on three-valued Walsh interpolation functions is proposed. Finally, through theoretical analysis and simulation, it is considered that comparing with the reconstructing method based on Walsh function system, using this paper’s method can achieve more ideal reconstruction results, although it will pay a small increase in the computational cost. The ideal reconstruction results mainly reflected in: the accuracy of the reconstructed signal is higher, the pulse waveform is relatively smooth, the orthogonality between the reconstructed pulses is more stable, and the frequency domain energy concentration of the reconstructed signal is substantially the same as the original signal. This method provides an effective theoretical reference for the hardware design of PSWF pulse real-time generation.
Efficiency and Crosstalk in Demultiplexing Orbital Angular Momentum Modes using a Geometrical Transformation-based Mode Sorter

There is a continuing growth for reaching higher communication bandwidth and multiplexing the information of independent channels to increase the channel capacity as much as possible. Orbital Angular Momentum (OAM) beams which are a subset of the Laguerre-Gaussian beams can be created by passing Gaussian beam through a Spiral Phase Plates (SPP). Their property that can be harnessed to be a candidate in Mode Division Multiplexing (MDM) systems have gained interest. OAM beams as carriers for multiple streams of input information can enhance the spectral efficiency and system capacity in an optical communication link. Analytical formulas for calculating efficiency and crosstalk of OAM modes passing through an OAM mode sorter is derived. With the help of these metrics, the channel capacity of the system and techniques for increasing it is discussed.
BugsJS: a Benchmark of JavaScript Bugs

JavaScript is a popular programming language that is also error-prone due to its asynchronous, dynamic, and loosely-typed nature. In recent years, numerous techniques have been proposed for analyzing and testing JavaScript applications. However, our survey of the literature in this area revealed that the proposed techniques are often evaluated on different datasets of programs and bugs. The lack of a commonly used benchmark limits the ability to perform fair and unbiased comparisons for assessing the efficacy of new techniques. To fill this gap, we propose BugsJS, a benchmark of 453 real, manually validated JavaScript bugs from 10 popular JavaScript server-side programs, comprising 444k LOC in total. Each bug is accompanied by its bug report, the test cases that detect it, as well as the patch that fixes it. BugsJS features a rich interface for accessing the faulty and fixed versions of the programs and executing the corresponding test cases, which facilitates conducting highly-reproducible empirical studies and comparisons of JavaScript analysis and testing tools.
Efficient Evaluation of Multi-Column Selection Predicates in Main-Memory

Efficient evaluation of selection predicates is a performance-critical task, for instance to reduce intermediate result sizes being the input for further operations. With analytical queries getting more and more complex, the number of evaluated selection predicates per query and table rises, too. This leads to numerous multi-column selection predicates. Recent approaches to increase the performance of main-memory databases for selection-predicate evaluation aim at optimally exploiting the speed of the CPU by using accelerated scans. However, scanning each column one by one leaves tuning opportunities open that arise if all predicates are considered together. To this end, we introduce Elf, an index structure that is able to exploit the relation between several selection predicates. Elf features cache sensitivity, an optimized storage layout, fixed search paths, and slight data compression. In a large-scale evaluation, we compare its query performance to state-of-the-art approaches and a sequential scan using SIMD capabilities. Our results indicate a clear superiority of our approach for queries returning less than 10 percent of all tuples – a selectivity almost one order of magnitude larger than observed for related indexing approaches. For TPC-H queries with multi-column selection predicates, we achieve a speedup between factor five and two orders of magnitude, mainly depending on the selectivity of the predicates. Further scaling experiments reveal that for large data sets, these speedup factors are expected to increase, due to more densely populated data spaces. Finally, our results indicate that using a delta-store like concept to support periodic insertions results in virtually no performance penalty for reasonable sizes of a write-optimized Elf as delta store.
Research on Network Behavior Anomaly Analysis Based on Bidirectional LSTM

With the rapid development of the Internet, the methods of Cyber Attack have become more complex and the damage to the world has become increasingly greater. Therefore, timely detection of malicious behavior on the Internet has become an important security issue today. This paper proposes an Intrusion Detection System based on deep learning, applies Bidirectional Long Short-Term Memory architecture to the system, and uses the UNSW-NB15 data set for training and testing. Experimental tests show that the Intrusion Detection System can effectively detect the known or unknown malicious behavior of the network under the current network environment.
RNA polymerase beta-subunit gene (rpoB) sequence analysis for the identification of Bacteroides spp.

Partial rpoB sequences (317 bp) of 11 species of Bacteroides, two Porphyromonas spp. and two Prevotella spp. were compared to delineate the genetic relationships among Bacteroides and closely related anaerobic species. The high level of inter-species sequence dissimilarities (7.6-20.8%) allowed the various Bacteroides spp. to be distinguished. The position of the Bacteroides distasonis and Bacteriodes merdae cluster in the rpoB tree was different from the position in the 16S rRNA gene tree. Based on rpoB sequence similarity and clustering in the rpoB tree, it was possible to correctly re-identify 80 clinical isolates of Bacteroides. In addition to two subgroups, cfiA-negative (division I) and cfiA-positive (division II), of Bacteroides fragilis isolates, two distinct subgroups were also found among Bacteroides ovatus and Bacteroides thetaiotaomicron isolates. Bacteroides genus-specific rpoB PCR and B. fragilis species-specific rpoB PCR allowed Bacteroides spp. to be differentiated from Porphyromonas and Prevotella spp. , and also allowed B. fragilis to be differentiated from other non-fragilisBacteroides spp. included in the present study.
Intelligent Identification of Microscopic Visible Components in Leucorrhea Routine

Leucorrhea routine is a common way of female physiological examination, which is detected by recognizing and counting the visible components in microscopic images. At present, the research in this field is still blank. Based on the deep learning theory, an improved R-CNN model is proposed to realize the intelligent recognition of the visible components in leucorrhea microscopic images. The detection precision of the algorithm is high, reaching 93.6%, and the detection time is 300 ms. The proposed algorithm provides a theoretical basis for the realization of leucorrhea routine automation and intellectualization.
An inhibitory effect of vitamin A on the induction of tumors of forestomach and cervix in the Syrian hamster by carcinogenic polycyclic hydrocarbons.

SUMMARY The oral administration of 7 , 12-dimethylbenzanthracene (DMBA) or benzo(a) pyrene(Bp) to Syrian hamsters induced dyskeratotic lesions and carcinoma of the forestomach and small intestine but only the DMBA induced dyskeratotic lesions of the esophagus. Painting the uterine cervix of Syrian hamsters with DMBA in duced perineal skin and vaginal carcinoma in 100% of the animals and cervical car cinoma in 22 % of the animals. In animals similarly treated with DMBA or Bp the addition of 0.5 % vitamin Apalmitate to the diet prevented the development of carcinoma of the gastrointestinal tract ; adding the vitamin A-palmitate to the fluid used for painting the cervix pre vented the development of carcinoma of cervix and vagina but did not inhibit the development of carcinoma of the perineal skin. The implication of the inhibitory effect of Vitamin A on the induction of squamous cell carcinoma of the mucous meni branes in the hamster is considered.
Capsule Neural Networks and Visualization for Segregation of Plastic and Non-Plastic Wastes

Building an image processing model for prediction or classification application has to overcome quite a lot of challenges. Convolutional neural network (CNN) is the pillar of image processing in deep learning perspective. In order to bring down the disadvantages and for improving the performance compared to the CNN, a new architecture of CNN had been devised which is known as Capsule neural network (Capsule-Net). By this paper we analyze Capsule-Net for solid waste management which is separation of plastic and non-plastic. This task is viewed as of at most significance in today’s world due to volumes of waste generated and nonavailability of human labor for this work. The capsule-Net is evaluated using 2 different datasets. Dataset 1 represents materials collected from public places and Dataset 2 represents materials collected from private environment. The proposed architecture with capsule-Net gives an accuracy of 96.3% for Dataset 1 and 95.7% for Dataset 2. The necessary hardware setup has been developed and tested. This will be a grace to the society which faces unexplainable difficulty in disposing wastes. It is inexpensive labor free and harmless to health.
Long noncoding RNA BCAR4 promotes glioma cell proliferation via EGFR/PI3K/AKT signaling pathway

Long noncoding RNA Breast Cancer Antiestrogen Resistance 4 (BCAR4) has been identified to be oncogenic in several cancers. In our study, we demonstrated that BCAR4 expression was significantly upregulated in glioma tissues compared with paired nontumor tissues. In addition, higher BCAR4 level was associated with poor overall survival in patients with glioma. Besides, we also discovered that knockdown of BCAR4 inhibited cell proliferation, whereas BCAR4 overexpression promoted this process. Intriguingly, we proved a cellular transformation of normal human astrocyte cells (NHAs) in response to enforced expression of BCAR4. In addition, we revealed that BCAR4 affected cell proliferation in glioma cells by promoting cell cycle progression and inhibiting cell apoptosis. Mechanistically, we uncovered that BCAR4 activated PI3K/AKT signaling pathway in glioma through upregulating EGFR and interacting with it. Moreover, activating PI3K/AKT pathway could reverse the repressive effects caused by BCAR4 silence on the biological behaviors of glioma cells, whereas inhibition of this pathway rescued the impact of BACR4 upregulation in NHAs. These findings disclosed that BCAR4 contributes to glioma progression by enhancing cell growth via activating EGFR/PI3K/AKT pathway, providing potent evidence that BCAR4 could be an effective new target for treatment and prognosis of glioma patients.
THE INHIBITORY EFFECT OF GALLAMINE ON MUSCARINIC RECEPTORS

1 The inhibitory effect of gallamine (1.1 μM‐1.1 mM) on negative inotropic responses to acetylcholine (ACh) or carbachol (CCh) was investigated in isolated electrically stimulated atria of the guinea‐pig. Gallamine caused parallel rightward shifts of the dose‐response curves to the agonists, with no depression of the maximal response. 2 Gallamine (0.11‐1.1 mM) produced a greater degree of antagonism towards CCh than towards ACh. With either agonist, the degree of antagonism produced by gallamine in high concentrations was less than that expected for a competitive antagonist. 3 Similar findings were made when either negative inotropic or chronotropic responses were recorded in spontaneously beating guinea‐pig atria. The inhibitory effect of gallamine against the negative inotropic response to cholinomimetics in electrically stimulated atria was not altered either in the presence of propranolol (17 μM) or in atria obtained from guinea‐pigs pretreated with diisopropylphosphorofluoridate (DFP) (12.5 μmol/kg, in divided doses over 3 days). 4 When ACh was used as the agonist, combination of gallamine with atropine (0.05‐0.4 μM) produced dose‐ratios which were less than expected for combination of two competitive antagonists. The same phenomenon was observed in atria obtained from guinea‐pigs pretreated with DFP. 5 It is suggested that the antagonism produced by gallamine is a type of non‐competitive inhibition, which has been termed ‘metaffinoid antagonism’. An antagonist of this type allosterically alters the affinity of the agonist for its binding site, rather than changing the effectiveness of the agonist‐receptor interaction.
Deterministic Optimality of the Steady-State Behavior of the Kalman–Bucy Filter

In this letter, we provide a deterministic characterization of optimality of the steady-state behavior of the Kalman–Bucy filter, via an inverse optimal control argument. The result is achieved in two steps, both interesting per se. First, a singular linear-quadratic (LQ) optimal control problem is formulated and solved with respect to the innovation term of a classic Luenberger observer, hence yielding a LQ optimal observer. Then, such a construction is employed to interpret the optimality of the steady-state behavior of the celebrated Kalman–Bucy filter in a purely deterministic sense.