Miracle-dz/UniFAR-FTUs huggingface dataset:
Analysis of the e-commerce use behavior on music products

The rapid growth of internet users in Indonesia in the last decade has implications in almost all aspects of life including the growing use of the internet to download music. This phenomenon attracts the attention of music business stakeholders. Many researchers have developed a Technology Adoption Model (TAM) that incorporates aspects beyond the technology into the model, which came to be known as Unified Theory of Acceptance and Use of Technology (UTAUT), and subsequently refined into the UTAUT-2 model. There is a gap between the results of research that is very likely due to differences in the objects studied, differences in moderation variables, and variations of the antecedents themselves. However, there have been no reports of research results using UTAUT-2 model for e-commerce music. The general objective of this research is to propose the appropriate model of UTAUT-2 for music e-commerce, and examine the effect of seven antecedent variables on behavior intention variables and their impact on use behavior. This quantitative research uses SEM techniques with 400 ordinal data taken from survey. Three of seven proposed variables which are accepted as antecedent variables of behavior intention are performance expectation, music piracy judgment and habit. For academics, the results of this research provide an alternative UTAUT model, specifically for music business. While for the online music business, the results of this research provide guidance on how to increase music business that ultimately boosts online music subscription.
Survey Item-Response Behavior as an Imperfect Proxy for Unobserved Ability: Theory and Application

We develop and test an economic model of the cognitive and non-cognitive foundations of survey item-response behavior. We show that a summary measure of response behaviour - the survey item-response rate (SIRR) - varies with cognitive and less so with non-cognitive abilities, has a strong individual fixed component and is predictive of economic outcomes because of its relationship with ability. We demonstrate the usefulness of SIRR, although an imperfect proxy for cognitive ability, to reduce omitted-variable biases in estimated wage returns. We derive both necessary and sufficient conditions under which the use of an imperfect proxy reduces such biases, providing a general guideline for researchers.
Number of harvested lymph nodes is the main prognostic factor in Stage IIa colorectal cancer patients

Current international guidelines on colorectal cancer (CRC) treatment suggest performing adjuvant chemotherapy only in Stage II patients presenting with high‐risk prognostic factors. Aim of the study was to a the impact of these parameters on the survival of Stage IIa CRC patients, focusing on the prognostic value of the number of harvested lymph nodes (NHLN).
A novel fusion of the MALT1 gene and the microtubule‐associated protein 4 (MAP4) gene occurs in diffuse large B‐cell lymphoma

Rearrangements of the MALT1 gene by the t(11;18)(q21;q21) and t(14;18)(q32;q21) are the most frequent structural chromosomal abnormalities in MALT lymphomas. These translocations lead to fusions of BIRC3–MALT1 and IGH–MALT1 respectively, and activate the NF‐κB pathway. Among 122 diffuse large B‐cell lymphomas and 28 Burkitt's lymphomas screened by interphase FISH, we found two cases with a break within MALT1, but without a t(11;18) or a t(14;18). Molecular genetic analyses in one of these cases revealed a novel “in frame” fusion of exon 9 of MALT1 and exon 9 of the microtubule‐associated protein 4 (MAP4) gene. The translocation was accompanied by a deletion of MALT1 sequences distal to the breakpoint including the caspase‐like domain, which is essential for activation of NF‐κB. As a result of the deletion, the reciprocal 5′MAP4‐3′MALT1 transcript was not present, demonstrating that the 5′MALT1‐3′MAP4 fusion represents the pathogenetically relevant transcript. Immunohistochemistry with amino‐terminal and carboxy‐terminal MALT1 antibodies, indicated a strong expression of the chimeric MALT1–MAP4 protein. Moreover, NF‐κB activation was not increased in this case as shown by the levels of IκBα phosphorylation and NEMO ubiquitination. Our data demonstrate that the pathogenetic consequences of the novel MALT1–MAP4 fusion are different from those of the known MALT1‐associated chromosomal rearrangements and do not involve NF‐κB activation. © 2006 Wiley‐Liss, Inc.
Examining the Potential Impact for Interdisciplinary Co-Teaching: An Action Research Study Exploring the Effects of Interdisciplinary Co-Teaching in Middle Grades English Language Arts and Social Studies

SHELOW, GABRIELLA REMINGTON. Examining the Potential Impact for Interdisciplinary Co Teaching: An Action Research Study Exploring the Effects of Interdisciplinary Co-Teaching in Middle Grades English Language Arts and Social Studies. (Under the direction of Carl Young). This study explores the effect on students when English Language Arts and Social Studies are co-taught using an interdisciplinary model. This study was conducted over the course of one school year and examines students’ growth and overall student experience. By looking at multiple data sets including students’ performance on standardized and teacher-made assessments, as well as students attitudes throughout the process, the teacher researcher was able to make conclusions about the effectiveness of the interdisciplinary co-teaching model.
Kinetics of the Interactions between Yeast Elongation Factors 1A and 1Bα, Guanine Nucleotides, and Aminoacyl-tRNA*

The interactions of elongation factor 1A (eEF1A) from Saccharomyces cerevisiae with elongation factor 1Bα (eEF1Bα), guanine nucleotides, and aminoacyl-tRNA were studied kinetically by fluorescence stopped-flow. eEF1A has similar affinities for GDP and GTP, 0.4 and 1.1 μm, respectively. Dissociation of nucleotides from eEF1A in the absence of the guanine nucleotide exchange factor is slow (about 0.1 s–1) and is accelerated by eEF1Bα by 320-fold and 250-fold for GDP and GTP, respectively. The rate constant of eEF1Bα binding to eEF1A (107–108 m –1 s–1) is independent of guanine nucleotides. At the concentrations of nucleotides and factors prevailing in the cell, the overall exchange rate is expected to be in the range of 6 s–1, which is compatible with the rate of protein synthesis in the cell. eEF1A·GTP binds Phe-tRNAPhe with a Kd of 3 nm, whereas eEF1A·GDP shows no significant binding, indicating that eEF1A has similar tRNA binding properties as its prokaryotic homolog, EF-Tu.
Repopulation of Leydig cells in mature rats after selective destruction of the existent Leydig cells with ethylene dimethane sulfonate is dependent on luteinizing hormone and not follicle-stimulating hormone.

After selective destruction of Leydig cells in mature rats with ethylene dimethane sulfonate (EDS), repopulation of Leydig cells occurs. This repopulation process was studied in normal and sterile (prenatally irradiated) rats using morphological and histochemical techniques and by measuring hormone concentrations. Three days after administration of EDS to normal rats, extensive Leydig cell degeneration had occurred, testosterone concentrations were decreased to less than 10% of the normal value, and no 3 beta-hydroxysteroid dehydrogenase activity or pregnenolone production could be detected in isolated interstitial cells. Seven days after EDS administration, no cells with the appearance of Leydig cells were observed, and steroidogenic activities were still absent. After 14 days, single or paired Leydig cells were present again in the interstitium, but only after 21 days an increase in the plasma testosterone concentration and LH-dependent pregnenolone production was observed. On day 35, numerous Leydig cells were present, and testosterone levels were restored to normal. The depletion and repopulation of Leydig cells after administration of EDS to sterile rats showed a somewhat different pattern. Three days after administration of EDS, testosterone concentrations were decreased to less than 10% of the normal value, and isolated interstitial cells showed no steroidogenic activities as in normal rats, but a small number of Leydig cells was still present. A similar picture was observed between 4 and 9 days after EDS administration. This indicates that some Leydig cells from sterile rats, unlike Leydig cells from normal rats, were resistant to EDS. The repopulation of Leydig cells in sterile rats was faster than in normal rats. After 14 days, many groups of Leydig cells were present in the interstitium, and the plasma testosterone concentration and pregnenolone production in vitro were significantly increased. Normal plasma testosterone levels were restored on day 21. Serum LH and FSH were decreased immediately after EDS administration, but during the next days a sharp rise was observed in both normal and sterile rats. The rise in LH correlated with the decrease in testosterone, and restoration of LH levels took place when testosterone levels increased. FSH levels changed similarly, but were delayed, in comparison to LH. In rats with testosterone implants that suppressed LH levels to less than 2 ng/ml and maintained normal FSH levels, ranging from 150-340 ng/ml, as well as in hypophysectomized rats, no repopulation of Leydig cells could be observed until 35 days after EDS treatment. (ABSTRACT TRUNCATED AT 400 WORDS)
MUC4 (Sialomucin Complex) Expression in Salivary Gland Tumors and Squamous Cell Carcinoma of the Upper Aerodigestive Tract

OBJECTIVES: This study investigates MUC4 expression in normal squamous epithelia and squamous cell carcinoma (SCC) of the upper aerodigestive tract (UADT), and in salivary gland neoplasms. STUDY DESIGN: MUC4 antigens in tumor and adjacent normal tissue are localized by immunocytochemical studies. Fresh frozen tissues from surgical resection specimens are further analyzed by Western blot. RESULTS: MUC4 is identified by immunocytochemical staining throughout the normal UADT mucosa, in 34 of 40 primary UADT SCC, and in 11 of 12 metastatic cervical lymph nodes. A trend toward decreased MUC4 staining in moderately and poorly differentiated tumors is noted. Immunoblots show MUC4 in 4 of 5 SCC analyzed. Immunocytochemical staining of MUC4 in 13 major and minor salivary gland neoplasms reveal variable staining of normal and neoplastic tissue. MUC4 is demonstrated in immunoblots of normal parotid tissue and in the single parotid malignancy analyzed, but is not demonstrated in one minor salivary gland malignancy. These findings characterize normal UADT mucosal and salivary MUC4 expression, and MUC4 expression in SCC of the UADT and in salivary gland tumors. SIGNIFICANCE: Correlation of MUC4 expression with clinical outcomes may establish MUC4 as a potential molecular prognostic marker for these tumors.
Peroneal Tendon Abnormalities on Routine Magnetic Resonance Imaging of the Foot and Ankle

Background: Abnormalities of the peroneal tendons can frequently be identified on routine MRI of the foot and ankle. Previous studies in the orthopedic literature have discussed the prevalence of abnormal MRI findings in asymptomatic patients, most notably with regards to the spine and shoulder. The purpose of this study was to determine the prevalence of abnormal findings of the peroneal tendons on MRI in asymptomatic individuals. Methods: We retrospectively reviewed all foot and ankle MRIs from 2 independent time periods that were either performed or reviewed at our institution. Studies were excluded if performed on patients with documented inversion injuries, ankle sprains, or lateral ankle trauma. A total of 294 (of 617) MRIs were eligible for inclusion in this study. A single attending musculoskeletal radiologist reviewed each MRI. Pathologies of the peroneal tendons included tendinosis, tenosynovitis, acute tears, chronic tears, and tendon splits. Additionally, the primary pathology encountered on each MRI was noted. The mean age of the MRIs included in this study was 46.8 years (range 9-82) with 155 females and 139 males. Results: The most commonly occurring primary pathology was Achilles tendinosis/tears (86), followed by posterior tibial tendon dysfunction (43). With regards to the peroneal tendons, 103 of the 294 (35%) MRIs demonstrated some pathology. Conclusion: The results of this study demonstrated that a sizeable percentage of asymptomatic individuals could have peroneal tendon pathology on MRI of the foot and ankle. This study can have important clinical implications for when patients present with concerning MRI findings that do not correlate clinically. Physicians providing musculoskeletal care can counsel and reassure patients who present with peroneal pathology on MRI but an absence of clinical findings. Level of Evidence: Level IV, case series.
Exploring Spatially Varying Influences on Metro-Bikeshare Transfer: A Geographically Weighted Poisson Regression Approach

The primary objective of this study was to explore the factors that influence metro-bikeshare ridership from a spatial perspective. First, a reproducible method of identifying metro-bikeshare transfer trips was derived using two types of smart-card data (metro and bikeshare). Next, a geographically weighted Poisson regression (GWPR) model was established to explore the relationships between metro-bikeshare transfer volume and several types of independent variables, including sociodemographic, travel-related, and built-environment variables. Moran’s I statistic was applied to examine the spatial autocorrelation of each explanatory variable. The modeling and spatial visualization results show that riding distance is negatively correlated with metro-bikeshare transfer demand, and the coefficient values are generally lower at the edge of the city, especially in underdeveloped areas. Moreover, the density of bus, bikeshare, and other metro stations within 2 km of a metro station has different impacts on metro-bikeshare transfer volume. Travelers whose origin or destination is entertainment related tend to choose bikeshare as a feeder mode to metro if this trip mode is available to them. These results improve our understanding of metro-bikeshare transfer spatial patterns, and several suggestions are provided for improving the integration between metro and bikeshare.
A heterotrimer model of the complete Microprocessor complex revealed by single-molecule subunit counting

During microRNA (miRNA) biogenesis, the Microprocessor complex (MC), composed minimally of Drosha, an RNaseIII enzyme, and DGCR8, a double-stranded RNA-binding protein, cleaves the primary-miRNA (pri-miRNA) to release the pre-miRNA stem–loop structure. Size-exclusion chromatography of the MC, isolated from mammalian cells, suggested multiple copies of one or both proteins in the complex. However, the exact stoichiometry was unknown. Initial experiments suggested that DGCR8 bound pri-miRNA substrates specifically, and given that Drosha could not be bound or cross-linked to RNA, a sequential model for binding was established in which DGCR8 bound first and recruited Drosha. Therefore, many laboratories have studied DGCR8 binding to RNA in the absence of Drosha and have shown that deletion constructs of DGCR8 can multimerize in the presence of RNA. More recently, it was demonstrated that Drosha can bind pri-miRNA substrates in the absence of DGCR8, casting doubt on the sequential model of binding. In the same study, using a single-molecule photobleaching assay, fluorescent protein-tagged deletion constructs of DGCR8 and Drosha assembled into a heterotrimeric complex on RNA, comprising two DGCR8 molecules and one Drosha molecule. To determine the stoichiometry of Drosha and DGCR8 within the MC in the absence of added RNA, we also used a single-molecule photobleaching assay and confirmed the heterotrimeric model of the human MC. We demonstrate that a heterotrimeric complex is likely preformed in the absence of RNA and exists even when full-length proteins are expressed and purified from human cells, and when hAGT-derived tags are used rather than fluorescent proteins.
Women Victims of Armed Conflict: Half-widows in Jammu and Kashmir

The armed conflict in Jammu and Kashmir has given rise to a category of women known as ‘half-widows’. These are women whose husbands have gone missing in the on-going armed conflict of over twenty years in the region. The paper presents an analysis of the economic, legal, social, and psychological implications of halfwidowhood in the cultural context of the region. It is based on a study of twelve half-widows using in-depth interviews in 2010. Drawing upon personal accounts of these women, it focuses on their experience of loss, the ostracism and stigma faced by them, and their struggle for survival and justice. It also brings to light their agential aspects in the conflict.
The transcription factor grainyhead-like 2 regulates the molecular composition of the epithelial apical junctional complex

Differentiation of epithelial cells and morphogenesis of epithelial tubes or layers is closely linked with the establishment and remodeling of the apical junctional complex, which includes adherens junctions and tight junctions. Little is known about the transcriptional control of apical junctional complex components. Here, we show that the transcription factor grainyhead-like 2 (Grhl2), an epithelium-specific mammalian homolog of Drosophila Grainyhead, is essential for adequate expression of the adherens junction gene E-cadherin and the tight junction gene claudin 4 (Cldn4) in several types of epithelia, including gut endoderm, surface ectoderm and otic epithelium. We have generated Grhl2 mutant mice to demonstrate defective molecular composition of the apical junctional complex in these compartments that coincides with the occurrence of anterior and posterior neural tube defects. Mechanistically, we show that Grhl2 specifically associates with cis-regulatory elements localized at the Cldn4 core promoter and within intron 2 of the E-cadherin gene. Cldn4 promoter activity in epithelial cells is crucially dependent on the availability of Grhl2 and on the integrity of the Grhl2-associated cis-regulatory element. At the E-cadherin locus, the intronic Grhl2-associated cis-regulatory region contacts the promoter via chromatin looping, while loss of Grhl2 leads to a specific decrease of activating histone marks at the E-cadherin promoter. Together, our data provide evidence that Grhl2 acts as a target gene-associated transcriptional activator of apical junctional complex components and, thereby, crucially participates in epithelial differentiation.
Celiac disease in adults: evaluation with MDCT enteroclysis.

OBJECTIVE The purpose of this article is to present the MDCT enteroclysis features of the multiple complications of celiac disease and illustrate why this technique is helpful to adult patients with celiac disease. CONCLUSION MDCT enteroclysis findings can suggest the diagnosis in adult patients with unknown celiac disease, and many complications of celiac disease can be recognized because of their characteristic appearance. Familiarity with these signs can help in appropriate planning of further diagnostic procedures.
Attention Network Dysfunction and Treatment Response of Geriatric Depression

The Attention Network Test was used to assess the efficiency of the executive, orienting and vigilance attention networks and their association to treatment response in older patients with major depression. There were no significant performance differences between depressives and controls. However, within the depressed group, executive-related performance, but not orienting- or vigilance-related performance was correlated with time to remission. The association of executive-attention network efficiency and antidepressant response provides the background for focused structural and functional neuroimaging studies aimed at identifying the functional neuroanatomy of antidepressant response.
Primary liver transplantation for autoimmune hepatitis: A comparative analysis of the European Liver Transplant Registry

The principal aim of this study was to compare the probability of and potential risk factors for death and graft loss after primary adult and pediatric liver transplantation in patients undergoing transplantation for autoimmune hepatitis (AIH) to those in patients undergoing transplantation for primary biliary cirrhosis (PBC; used as the reference group) or alcoholic cirrhosis (used as an example of a nonautoimmune liver disease). The 5‐year survival of patients undergoing transplantation for AIH (n = 827) was 0.73 [95% confidence interval (CI) = 0.67‐0.77]. This was similar to that of patients undergoing transplantation for alcoholic cirrhosis (0.74, 95% CI = 0.72‐0.76, n = 6424) but significantly worse than that of patients undergoing transplantation for PBC (0.83, 95% CI = 0.80‐0.85, n = 1588). Fatal infectious complications occurred at an increased rate in patients with AIH (hazard ratio = 1.8, P = 0.002 with PBC as the reference). The outcome of pediatric AIH patients was similar to that of adult patients undergoing transplantation up to the age of 50 years. However, the survival of AIH patients undergoing transplantation beyond the age of 50 years (0.61 at 5 years, 95% CI = 0.51‐0.70) was significantly reduced in comparison with the survival of young adult AIH patients (0.78 at 18‐34 years, 95% CI = 0.70‐0.86) and in comparison with the survival of patients of the same age group with PBC or alcoholic cirrhosis. In conclusion, age significantly affects patient survival after liver transplantation for AIH. The increased risk of dying of infectious complications in the early postoperative period, especially above the age of 50 years, should be acknowledged in the management of AIH patients with advanced‐stage liver disease who are listed for liver transplantation. It should be noted that not all risk factors relevant to patient and graft survival could be analyzed with the European Liver Transplant Registry database. Liver Transpl , 2010. © 2010 AASLD.
Sleep Disorders Among Holocaust Survivors: A Review of Selected Publications

Abstract After World War II, traumatic after effects often caused persistent sleep disorders for Holocaust survivors (HSs). This is a review of studies reporting on sleep disturbances and nightmares (as primary or secondary outcomes) among HSs between 1939 and 2015, conducted in various countries and contexts (clinical settings, pension claims, community surveys, sleep laboratories). Most studies revealed various sleep disturbances among HSs. Some studies found those disturbances in the absence of clinical disorders. Both men and women reported similar frequencies of sleep disturbances, although posttraumatic stress disorder and depression were more frequent in women. Sleep laboratory studies provided the single most direct and detailed sources of information. Findings included a) long-standing changes in sleep architecture, for example, decreased rapid eye movement (REM) sleep, and b) contrasting patterns of dreaming and recall among better versus poorly adjusted survivors. These results are of importance to both HSs and their families and for medical and mental health professionals.