Miracle-dz/UniFAR-FTUs huggingface dataset:
Systematic review of oncology nurse practitioner navigation metrics.

BACKGROUND Nurse practitioners should become more active in patient navigation and its subcomponent, care coordination, because research has shown that these roles are influential in improving patient care at all levels of an organization. Well-defined process and outcome measures, as well as educational initiatives, are critical to these programs because they serve as the structure for program evaluation. OBJECTIVES This article aims to assess and define metrics that nurse practitioners in the oncology setting can use to evaluate navigation programs, which is essential for the evolution of research pertaining to the navigation field. METHODS The current article is a systematic review that describes oncology nurse practitioner navigation metrics using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) format for the systematic literature review process. These metrics are then compared to current standards of care. FINDINGS Seven studies met the criteria for this review. Research is emerging that shows benefit in using an oncology nurse practitioner navigator for ensuring timely care and patient and staff satisfaction. These metrics are in line with expert consensus recommendations. The need for more research identifying sound research tools that have been rigorously tested has been identified.
Resident and proprietor perspectives on a recovery orientation in community-based housing.

OBJECTIVE Stable housing is a fundamental human right, and an important element for both mental health recovery and social inclusion among people with serious mental illness. This article reports findings from a study on the recovery orientation of structured congregate community housing services using the Recovery Self-Assessment Questionnaire (RSA) adapted for housing (O'Connell, Tondora, Croog, Evans, & Davidson, 2005). METHODS The RSA questionnaires were administered to 118 residents and housing providers from 112 congregate housing units located in Montreal, Canada. RESULTS Residents rated their homes as significantly less recovery-oriented than did proprietors, which is contrary to previous studies of clinical services or Assertive Community Treatment where RSA scores for service users were significantly higher than service provider scores. Findings for both groups suggest the need for improvement on 5 of 6 RSA factors. While proprietors favored recovery training and education, and valued resident opinion and experience, vestiges of a traditional medical model governing this housing emerged in other findings, as in agreement between the 2 groups that residents have little choice in case management, or in the belief among proprietors that residents are unable to manage their symptoms. CONCLUSIONS AND IMPLICATIONS FOR PRACTICE This study demonstrates that the RSA adapted for housing is a useful tool for creating recovery profiles of housing services. The findings provide practical guidance on how to promote a recovery orientation in structured community housing, as well as a novel approach for reaching a common understanding of what this entails among stakeholders. (PsycINFO Database Record
Regional Cerebral Blood Flow and Response to Carbon Dioxide during Controlled Hypotension with Isoflurane Anesthesia in the Rat

Regional (frontal, parietal, occipital, cortical, and basal ganglia) cerebral blood flow (rCBF) was examined at 1.5 and 3.5 MAC inspired isoflurane/O2 anesthesia in the rat using the radioactive microsphere technique to determine the effects of controlled hypotension with deep isoflurane anesthesia on rCBF and the response of rCBF to changes in Paco2 when mean blood pressure (BP) was decreased to levels below the lower limit of the autoregulatory threshold. Four groups of six rats were studied with rCBF 1 determined at 1.5 MAC (mean BP 80–90 mm Hg) followed by two rCBF determinations at 3.5 MAC (mean BP 46–48 mm Hg). For CBF 1 the regional CO2 response was a 3.1–3.9% increase in rCBF/mm Hg increase in CO2- Regional cerebral blood flow (ml/g/min) ranged from 0.64 ± 0.05–0.83 ± 0.15 at Paco2 of 19 mm Hg to 1.34 ± 0.11–1.80 ± 0.33 at Paco2 of 41 mm Hg to 2.61 ± 0.26–3.72 ± 0.37 at Paco2 of 59 mm Hg (mean ± SEM). With controlled hypotension (CBF 2) rCBF was unchanged during normo-carbia, increased 100% during hypocarbia, P < 0.01 vs CBF 1 and decreased 30% during hypercarbia, P < 0.01 vs CBF 1. For rCBF 3 measurements, the BP and inspired concentration of isoflurane were kept constant, while Paco2 was increased in two and decreased in two of the four groups. Within-group comparisons between rCBF 2 and rCBF 3 results demonstrated loss of CO, responsiveness of the rat cerebrovasculature in every region during controlled hypotension to below the autoregulatory threshold at3.5 MAC isoflurane/O2 anesthesia. These results show that rCBF is well maintained in normal cerebral tissue when mean BP is decreased to below the autoregulatory threshold during controlled hypotension with deep isoflurane anesthesia.
Thermal strati " cation produced by plumes and jets in enclosed spaces

The air.ow and thermal strati"cation produced by a localised heat source located at . oor level in a closed room is of considerable practical interest and is commonly referred to as a ‘"lling box’. In rooms with low aspect ratios H=R.1 (room height H to characteristic horizontal dimension R) the thermal plume spreads laterally on reaching the ceiling and a descending horizontal ‘front’ forms separating a stably strati"ed, warm upper region from cooler air below. The strati"cation is well predicted for H=R.1 by the original "lling box model of Baines and Turner (J. Fluid. Mech. 37 (1968) 51). This model represents a somewhat idealised situation of a plume rising from a point source of buoyancy alone—in particular the momentum . ux at the source is zero. In practical situations, real sources of heating and cooling in a ventilation system often include initial . uxes of both buoyancy and momentum, e.g. where a heating system vents warm air into a space. This paper describes laboratory experiments to determine the dependence of the ‘front’ formation and strati"cation on the source momentum and buoyancy . uxes of a single source, and on the location and relative strengths of two sources from which momentum and buoyancy . uxes were supplied separately. For a single source with a non-zero input of momentum, the rate of descent of the front is more rapid than for the case of zero source momentum . ux and increases with increasing momentum input. Increasing the source momentum . ux e;ectively increases the height of the enclosure, and leads to enhanced overturning motions and "nally to complete mixing for highly momentum-driven . ows. Strati"ed . ows may be maintained by reducing the aspect ratio of the enclosure. At these low aspect ratios di;erent long-time behaviour is observed depending on the nature of the heat input. A constant heat . ux always produces a strati"ed interior at large times. On the other hand, a constant temperature supply ultimately produces a well-mixed space at the supply temperature. For separate sources of momentum and buoyancy, the developing strati"cation is shown to be strongly dependent on the separation of the sources and their relative strengths. Even at small separation distances the strati"cation initially exhibits horizontal inhomogeneity with localised regions of warm . uid (from the buoyancy source) and cool . uid. This inhomogeneity is less pronounced as the strength of one source is increased relative to the other. Regardless of the strengths of the sources, a constant buoyancy . ux source dominates after su? ciently large times, although the strength of the momentum source determines whether the enclosure is initially well mixed (strong momentum source) or stably strati"ed (weak momentum source). c © 2001 Elsevier Science Ltd. All rights reserved.
A family 11 carbohydrate-binding module (CBM) improves the efficacy of a recombinant cellulase used to supplement barley-based diets for broilers at lower dosage rates

1. Exogenous microbial β-1,3-1,4-glucanases and hemicellulases contribute to improving the nutritive value of cereals rich in soluble non-starch polysaccharides for poultry. 2. In general, plant cell wall hydrolases display a modular structure comprising a catalytic module linked to one or more non-catalytic carbohydrate-binding modules (CBMs). Based on primary structure similarity, CBMs have been classified in 50 different families. CBMs anchor cellulases and hemicellulases into their target substrates, therefore eliciting efficient hydrolysis of recalcitrant polysaccharides. 3. A study was undertaken to investigate the effects of a family 11 β-glucan-binding domain in the function of recombinant derivatives of cellulase CtLic26A-Cel5E of Clostridium thermocellum that were used to supplement a barley-based diet at lower dosage rates. 4. The results showed that birds fed on diets supplemented with the recombinant CtLic26A-Cel5E modular derivative containing the family 11 CBM or the commercial enzyme mixture Rovabio™ Excel AP tended to display improved performance when compared to birds fed diets not supplemented with exogenous enzymes. 5. It is suggested that at lower than previously reported enzyme dosage (10 U/kg vs 30 U/kg of basal diet), the β-glucan-binding domain also elicits the function of the recombinant CtLic26A-Cel5E derivatives. 6. Finally, the data suggest that exogenous enzymes added to barley-based diets act primarily in the proximal section of the gastrointestinal tract.
Prevalence, distribution, and viral load of human papillomavirus 16 DNA in tonsillar carcinomas

Oncogenic human papillomaviruses (HPV) DNA have repeatedly been observed in many head and neck carcinomas (HNSCCs), and HPV infections are currently considered a possible factor in the etiology of these tumors. However, the reported prevalences of HPV‐DNA in HNSCC are variable. In the current study the authors used highly sensitive polymerase chain reactions (PCRs) to analyze the occurrence of viral sequences in 98 carefully stratified HNSCCs. The authors determined the load and localization of HPV DNA in a subset of tonsillar carcinomas and their metastases.
Sulfite enhancement of diolepoxide mutagenicity: the role of altered glutathione metabolism.

Sulfur dioxide is a cocarcinogen for benzo[a]pyrene in the respiratory tract of rats and hamsters. Sulfur dioxide exists under physiological conditions as the sulfite ion. Sulfite enhances the mutagenic potency of (+-)-7r,8t-dihydroxy-9t,-10t- epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (anti-BPDE) and 7r,8t-dihydroxy-9c10c-epoxy-7,8,9,10-tetrahydrobenzo[a]py ren e (syn-BPDE) in Salmonella typhimurium strains TA98 and TA100. This enhancement of diolepoxide mutagenicity is observed with sulfite concentrations between 1 and 20 mM, and the concentration dependence is identical for the two diolepoxides. Half-maximal enhancement of mutagenicity occurs at approximately 5 mM sulfite. Sulfite is neither toxic nor mutagenic to the bacteria under these conditions. The enhancement of diolepoxide mutagenicity requires that the bacteria be exposed to sulfite prior to the addition of the diolepoxide. Simultaneous addition of sulfite and diolepoxide significantly decreases the enhancing effect, and addition 15 min after the diolepoxide virtually abolishes the effect. This is consistent with sulfite serving to increase the efficiency of processes leading to DNA modification by the diolepoxides, rather than some effect subsequent to DNA adduct formation. Direct evidence for this hypothesis was provided by determining the effect of sulfite on mutagenicity and DNA binding in TA98 using [3H]anti-BPDE. Exposure of the bacteria to 10 mM sulfite for 5 min prior to the addition of the labeled mutagen led to as much as 170% increase in DNA binding levels relative to parallel incubations without sulfite. Corresponding increases in mutagenicity were seen as well. As sulfite can affect the glutathione/glutathione-S-transferase systems, the primary cellular defense against BPDE, the effect of sulfite on these pathways in Salmonella was determined. When strain TA98 was treated with N-acetoxy-2-acetamidofluorene, a direct-acting mutagen not scavenged by glutathione, prior addition of 10 mM sulfite to the bacteria had no effect on resultant viability or mutagenicity. Assessment of the bacterial glutathione levels revealed that 10 mM sulfite treatment results in an 82% decrease in the concentration of the cosubstrate. We were, however, unable to detect diolepoxide-glutathione conjugates in any of our incubations. Moreover, the presence of sulfite leads to significant trapping of the diolepoxide in the form of sulfonate derivatives. Based on these data, we conclude that the depletion of glutathione does indeed play a role in the enhancement of diolepoxide mutagenicity in S. typhimurium. (ABSTRACT TRUNCATED AT 400 WORDS)
Response of cardiac endothelial nitric oxide synthase to plasma viscosity modulation in acute isovolemic hemodilution

Background: Endothelial nitric oxide synthase (eNOS) is generally expressed in endocardial cells, vascular endothelial cells and ventricular myocytes. However, there is no experimental study elucidating the relationship between cardiac eNOS expression and elevated plasma viscosity in low oxygen delivery pathological conditions such as hemorrhagic shock-resuscitation and hemodilution. This study tested the hypothesis that elevated plasma viscosity increases cardiac eNOS expression in a hemodilution model, leading to positive effects on cardiac performance. Materials and Methods: Two groups of golden Syrian hamster underwent an acute isovolemic hemodilution where 40% of blood volume was exchanged with 2% (low-viscogenic plasma expander [LVPE]) or 6% (high-viscogenic plasma expander [HVPE]) of dextran 2000 kDa. In control group, experiment was performed without hemodilution. All groups were performed in awake condition. Experimental parameters, i.e., mean arterial blood pressure (MAP), heart rate, hematocrit, blood gas content and viscosity, were measured. The eNOS expression was evaluated by eNOS Western blot analysis. Results: After hemodilution, MAP decreased to 72% and 93% of baseline in the LVPE and HVPE, respectively. Furthermore, pO 2 in the LVPE group increased highest among the groups. Plasma viscosity in the HVPE group was significantly higher than that in control and LVPE groups. The expression of eNOS in the HVPE group showed higher intensity compared to other groups, especially compared with the control group. Conclusion: Our results demonstrated that cardiac eNOS has responded to plasma viscosity modulation with HVPE and LVPE. This particularly supports the previous studies that revealed the positive effects on cardiac function in animals hemodiluted with HVPE.
The Nucleolar Localization Domain of the Catalytic Subunit of Human Telomerase*

Telomerase is the enzyme essential to complete the replication of the terminal DNA of most eukaryotic chromosomes. In humans, this enzyme is composed of the telomerase reverse transcriptase (hTERT) and telomerase RNA (hTR) subunits. hTR has been found in the nucleolus, a site of assembly of ribosomes as well as other ribonucleoproteins (RNPs). We therefore tested whether the hTERT component is also found in the nucleolus, where it could complex with the hTR RNA to form a functional enzyme. We report here that hTERT does indeed localize to the nucleolus, and we mapped the domain responsible for this localization to the hTR-binding region of the protein by deletion analysis. Substitution mutations in two of the three conserved hTR-binding domains in this nucleolarlocalization domain (NoLD) abolished nucleolar localization. However, another mutation that impeded hTR binding did not alter this subcellular localization. Additionally, wild type hTERT was detected in the nucleolus of cells that failed to express hTR. Taken together, we propose that the nucleolar localization of hTERT involves more than just the association with the hTR subunit. Furthermore, the coincidental targeting of both the hTR and hTERT subunits to the nucleolus supports the premise that the assembly of telomerase occurs in the nucleolus.
Alemtuzumab as compared to alternative contemporary induction regimens

Between 1 January 2002 and 31 December 2007, our center performed 1687 adult renal transplants. A retrospective analysis was performed to compare outcomes between patients receiving alemtuzumab (n = 632) and those receiving either basiliximab (n = 690) or thymoglobulin (n = 125). Patients receiving alemtuzumab were younger (49 vs. 51 years, P = 0.02), had fewer HLA matches (1.7 vs. 2.0, P < 0.0001), were more likely to have a cytomegalovirus (CMV) donor(+)/recipient(−) transplant (22% vs. 17%, P = 0.03) and were less likely to receive a living donor allograft (32% vs. 37%, P = 0.04). Alemtuzumab recipients were less likely to receive tacrolimus (35% vs. 47%, P < 0.0001). The 1‐, 3‐, and 5‐year cumulative incidence of antibody‐mediated rejection (AMR) in alemtuzumab‐treated patients was 19%, 24%, and 27%, vs. 11%, 15%, and 18% for the other group (P < 0.0001). The 1‐, 3‐, and 5‐year allograft survival in the alemtuzumab group was 88%, 75%, and 67%, vs. 91%, 82%, and 74% for the other group (P < 0.0001). Patient survival was equivalent. Alemtuzumab was an independent risk factor for living donor allograft loss (HR 2.0, P = 0.004), opportunistic infections (HR 1.3, P = 0.01), CMV infections (HR 1.6, P = 0.001), and AMR (HR 1.5, P = 0.002). The significantly worse graft survival in the alemtuzumab cohort may be due to the increased rates of AMR and infectious complications.
Esthetic Evaluation of Implant Crowns and Peri-Implant Soft Tissue in the Anterior Maxilla: Comparison and Reproducibility of Three Different Indices.

BACKGROUND A successful implant reconstruction with optimal esthetics consists of a visually pleasing prosthesis and complete and healthy surrounding soft tissue. In the current literature, numerous indices used to qualitatively assess esthetics have been described. However, studies comparing the indices and their reproducibility are scarce. PURPOSE The aim of this study was to compare three different esthetic indices for the evaluation of single implant-supported crowns. MATERIALS AND METHODS A total of 10 prosthodontists (P), 10 orthodontists (O), 10 general dentists (G), and 10 lay people (L) independently performed the same assessment using 30 photographs and corresponding casts with three different esthetic indices (Peri-Implant and Crown Index [PICI], Implant Crown Aesthetic Index [ICAI], "Pink Esthetic Score/White Esthetic Score [PES/WES]) and repeated the evaluations 4 weeks later. RESULTS The PES/WES and the PICI showed significantly higher esthetic scores (pink, white, total) and clinical acceptance compared with the ICAI in all four groups and in both assessments. The highest intraobserver agreement was achieved using the PES/WES and the least with the ICAI. The mean Kappa per group ranged from 0.18 (group L with ICAI) to 0.63 (group G with PICI). CONCLUSION In comparison with the ICAI, the PES/WES and PICI were more reproducible. Therefore, PES/WES and PICI seem to be more suitable as esthetic indices for single implant crowns.
Expression and regulatory role of receptors for vasoactive intestinal peptide in bone cells

An intense network of nerve fibers can be demonstrated in skeletal tissues, not only in the periosteum but also within cortical bone, growth plate, and bone marrow. This neuro‐osteogenic network expresses a restricted number of signalling molecules, including neuropeptides, neurotransmitters, and neurotrophins. Several lines of evidence indicate that receptors for these molecules are present on bone cells and that activation of these receptors leads to changes in bone cell activities. In addition, deletion of signalling molecules has been shown to alter bone metabolism. In the present review, these studies are summarized with a focus on distribution and effects of vasoactive intestinal peptide. Microsc. Res. Tech. 58:98–103, 2002. © 2002 Wiley‐Liss, Inc.
The Role of Innate Immunity in the Pathogenesis of Acne

Acne is a multifactorial disease of the pilosebaceous follicle. The most significant pathogenetic factors of acne are: abnormal ductal keratinization, increased sebum secretion, abnormalities of the microbial flora and inflammation. The pilosebaceous unit is an immunocompetent organ. Keratinocytes and sebocytes may act as immune cells capable of pathogen recognition and abnormal lipid presentation, and they might have an important role in initiating and perpetuating the activation of both innate and adaptive immune responses. The elements of the skin immune system are involved in the development of both noninflammatory and inflammatory acne lesions.
A conceptual model of entrepreneurial reputation from a venture capitalist’s perspective

Research on reputation has mainly focused on established companies ignoring the relevance of reputation for start-ups. However, start-ups also need to consider factors that influence their reputation with regard to different stakeholders, especially potential investors. In this article, we develop a model of the so-called ‘entrepreneurial reputation’ from a venture capitalist’s perspective. For that purpose, the RepTrak® System – a model of corporate reputation developed by the Reputation Institute – is discussed in the context of entrepreneurship. With the help of a literature review, we work out relevant criteria used by venture capitalists in their decision-making process of whether to invest or not to invest in a new venture and integrate these in the RepTrak® System. The following five dimensions appear to be the key drivers of entrepreneurial reputation from a venture capitalist’s perspective: (1) entrepreneur/team, (2) market/industry, (3) products/services, (4) innovation and (5) finance.
Long‐term direct CO2 flux measurements over a boreal lake: Five years of eddy covariance data

Significant amounts of terrestrial carbon are processed in lakes and emitted into the atmosphere as CO2. However, due to lack of appropriate measurements the absolute role of lakes in the landscape as sinks or sources of CO2 is still uncertain. We conducted the first long‐term, ecosystem‐level CO2 flux measurements with eddy covariance technique in a boreal lake within a natural‐state catchment covering 5 years. The aim was to reveal the natural level of CO2 flux between a lake and the atmosphere and its role in regional carbon cycling. On average, the lake emitted ca 10% of the terrestrial net ecosystem production of the surrounding old‐growth forest and the main immediate drivers behind the fluxes were physical rather than biological. Our results suggest that lakes are an integral part of terrestrial carbon cycling.