Miracle-dz/UniFAR-FTUs huggingface dataset:
Virulence Genotypes and Phylogenetic Background of Escherichia coli Serogroup O6 Isolates from Humans, Dogs, and Cats

ABSTRACT Molecular evidence is limited for the hypothesis that humans, dogs, and cats can become colonized and infected with similar virulent Escherichia coli strains. To further assess this possibility, archived E. coli O6 isolates (n = 130) from humans (n = 55), dogs (n = 59), and cats (n = 16), representing the three main H (flagellar) types within serogroup O6 (H1, H7, and H31), were analyzed, along with selected reference strains. Isolates underwent PCR-based phylotyping, multilocus sequence typing, PCR-based detection of 55 virulence-associated genes, and XbaI pulsed-field gel electrophoresis (PFGE) profiling. Three major sequence types (STs), which corresponded closely with H types, accounted for 99% of the 130 O6 isolates. Each ST included human, dog, and cat isolates; two included reference pyelonephritis isolates CFT073 (O6:K2:H1) and 536 (O6:K15:H31). Virulence genotypes overlapped considerably among host species, despite statistically significant differences between human and pet isolates. Several human and dog isolates from ST127 (O6:H31) exhibited identical virulence genotypes and highly similar PFGE profiles, consistent with cross-species exchange of specific E. coli clones. In conclusion, the close similarity in the genomic backbone and virulence genotype between certain human- and animal-source E. coli isolates within serogroup O6 supports the hypothesis of zoonotic potential.
Endogenous Social Interactions: Which Peers Matter?

This paper compares endogenous social interactions models to determine which one fits the classroom reality best. The analysis uses data from German 9th-graders and considers the effect of the best and worst peers scores, the peers sum and peers average scores on own achievement. Although each model seems plausible when estimated separately, comparison and a selection test point to the classmates average model, meaning that group-based policies are effective. The worst peers model comes second, followed by the best peers and the sum of peers models. Examination of different-ability students responses to increases of average peer achievement reveals either competition for the first place or last-place aversion. Conditional on own course preferences, own and peer characteristics, spillovers transmit only through cognitive ability. Therefore, regrouping on the basis of characteristics such as immigration background is obsolete. Policies should aim at low achievers in small enough classrooms because only then single-student influences can change the social norm. By improving the average through the worst, the best become even brighter.
Efficacy of kinesiotape on functional disability of women with postnatal back pain: A randomized controlled trial.

BACKGROUND Postpartum low back pain harmfully affects all parts of women's life. OBJECTIVE To investigate the effect of kinesiotape on women with postnatal backache. METHODS Thirty participants were randomly allocated to either group (A; n= 15), treated by kinesiotape with exercise program, or the group (B; n= 15), treated by exercise program. Visual analogue scale (VAS) and Back Pain Function Scale (BPFS) were evaluated.at baseline and after 2 weeks of intervention. RESULTS There were no statistically significant changes between group A and group B for baseline characteristics (p> 0.05). After two-week intervention, within group analyses revealed that VAS decreased (p< 0.05), with significant increase in BPFS (p> 0.05) in the two groups. Between group analyses showed that there was significant reduction of VAS (p< 0.05) and significant increase of BPFS (p< 0.05) in favor to group A than group B. CONCLUSIONS Kinesiotape and postural correction exercises can be recommended as effective treatment methods for women's postnatal back pain with better effect of kinesiotape and postural correction exercises than exercise alone.
Don't know responses to cognitive and affective risk perception measures: Exploring prevalence and socio‐demographic moderators

OBJECTIVES Many people report uncertainty when appraising their risk of cancer and other diseases, but prior research about the topic has focused solely on cognitive risk perceptions. We investigated uncertainty related to cognitive and affective risk questions. We also explored whether any differences in uncertainty between cognitive and affective questions varied in magnitude by item-specific or socio-demographic characteristics. DESIGN Secondary analysis of data collected for a 2 × 2 × 3 full-factorial risk communication experiment (N = 835) that was embedded within an online survey. METHODS We investigated the frequency of 'don't know' responses (DKR) to eight perceived risk items that varied according to whether they assessed (1) cognitive versus affective perceived risk, (2) absolute versus comparative risk, and (3) colon cancer versus 'any exercise-related diseases'. Socio-demographics were as follows: sex, age, education, family history, and numeracy. We analysed the data using multilevel logistic regression. RESULTS The odds of DKR were lower for affective than cognitive perceived risk (OR = 0.64, p < .001). This difference occurred for absolute but not comparative risk perceptions (interaction effect, p = .004), but no interactions for disease type or demographic characteristics were found (ps > .05). CONCLUSIONS Lower uncertainty for affective (vs. cognitive) absolute perceived risk items is consistent with research stating: (1) Risk perceptions are grounded in people's feelings about a hazard, and (2) feelings are easier for people to access than facts. Including affective perceived risk items in health behaviour surveys may reduce missing data and improve data quality. Statement of contribution What is already known on this subject? Many people report that they don't know their risk (i.e., risk uncertainty). Evidence is growing for the importance of feelings of risk in explaining health behaviour. Feelings are easier for people to access than facts. What does this study add? Don't know responding is higher for absolute cognitive than absolute affective risk questions. This difference does not vary in magnitude by demographic characteristics. Affective perceived risk questions in surveys may reduce missing data and improve data quality.
Locally produced xenin and the neurotensinergic system in pancreatic islet function and β-cell survival

Abstract Modulation of neuropeptide receptors is important for pancreatic β-cell function. Here, islet distribution and effects of the neurotensin (NT) receptor modulators, xenin and NT, was examined. Xenin, but not NT, significantly improved glucose disposal and insulin secretion, in mice. However, both peptides stimulated insulin secretion from rodent β-cells at 5.6 mm glucose, with xenin having similar insulinotropic actions at 16.7 mm glucose. In contrast, NT inhibited glucose-induced insulin secretion. Similar observations were made in human 1.1B4 β-cells and isolated mouse islets. Interestingly, similar xenin levels were recorded in pancreatic and small intestinal tissue. Arginine and glucose stimulated xenin release from islets. Streptozotocin treatment decreased and hydrocortisone treatment increased β-cell mass in mice. Xenin co-localisation with glucagon was increased by streptozotocin, but unaltered in hydrocortisone mice. This corresponded to elevated plasma xenin levels in streptozotocin mice. In addition, co-localisation of xenin with insulin was increased by hydrocortisone, and decreased by streptozotocin. Further in vitro investigations revealed that xenin and NT protected β-cells against streptozotocin-induced cytotoxicity. Xenin augmented rodent and human β-cell proliferation, whereas NT displayed proliferative actions only in human β-cells. These data highlight the involvement of NT signalling pathways for the possible modulation of β-cell function.
Regulating approaches to learning: Testing learning strategy convergences across a year at university

BACKGROUND Contemporary models of student learning within higher education are often inclusive of processing and regulation strategies. Considerable research has examined their use over time and their (person-centred) convergence. The longitudinal stability/variability of learning strategy use, however, is poorly understood, but essential to supporting student learning across university experiences. AIMS Develop and test a person-centred longitudinal model of learning strategies across the first-year university experience. METHODS Japanese university students (n = 933) completed surveys (deep and surface approaches to learning; self, external, and lack of regulation) at the beginning and end of their first year. Following invariance and cross-sectional tests, latent profile transition analysis (LPTA) was undertaken. RESULTS Initial difference testing supported small but significant differences for self-/external regulation. Fit indices supported a four-group model, consistent across both measurement points. These subgroups were labelled Low Quality (low deep approaches and self-regulation), Low Quantity (low strategy use generally), Average (moderate strategy use), and High Quantity (intense use of all strategies) strategies. The stability of these groups ranged from stable to variable: Average (93% stayers), Low Quality (90% stayers), High Quantity (72% stayers), and Low Quantity (40% stayers). The three largest transitions presented joint shifts in processing/regulation strategy preference across the year, from adaptive to maladaptive and vice versa. CONCLUSIONS Person-centred longitudinal findings presented patterns of learning transitions that different students experience during their first year at university. Stability/variability of students' strategy use was linked to the nature of initial subgroup membership. Findings also indicated strong connections between processing and regulation strategy changes across first-year university experiences. Implications for theory and practice are discussed.
The Relationship between Hardiness, Supervisor Support, Group Cohesion, and Job Stress as Predictors of Job Satisfaction

Purpose. This study tested a conceptual model based on research supporting the relationship between the predictors of hardiness, supervisor support, and group cohesion and the criterions of job stress and job satisfaction and between the predictor of job stress and the criterion of job satisfaction. Design. The study employed a cross-sectional research design. Survey data were collected as part of the baseline measures assessed prior to an organizational hardiness intervention. Setting. Worksite of Dell Computer Corporation in Austin, Texas. Subjects. The subjects included 160 full-time Dell employees recruited from a convenience sample representing nine work groups (response rate = 90%). Measures. Hardiness was measured using the Dispositional Resilience Scale (DRS), job stress was measured using the Perceived Work Stress Scale (PWSS), and supervisor support, group cohesion, and job satisfaction were measured using a proprietary employee attitude survey. Results. In the proposed model, high hardiness, supervisor support, and group cohesion were related to lower levels of job stress, which in turn was related to higher levels of job satisfaction. The model also proposed direct paths from hardiness, supervisor support, and group cohesion to job satisfaction. Path analysis was used to examine the goodness of fit of the model. The proposed model was a good fit for the data (χ2[1, N = 160] = 1.85, p = .174) with the exception of the direct path between group cohesion and job satisfaction. Substantial portions of the variances in job stress (R2 = .19) and job satisfaction (R2 = .44) were accounted for by the predictors. Conclusion. Implications for targeted worksite health promotion efforts to lower job stress and enhance job satisfaction are discussed.
Fracture Resistance of Titanium‐Based Lithium Disilicate and Zirconia Implant Restorations

PURPOSE To evaluate the fracture resistance of a newer lithium disilicate abutment material. MATERIALS AND METHODS A premolar-shaped implant crown was designed using CAD/CAM software, and four groups of implant and crown combinations were milled: (1) lithium-disilicate hybrid-abutment crown; (2) "screwmentable" lithium-disilicate hybrid abutment/lithium-disilicate crown with screw channel; (3) lithium-disilicate hybrid abutment/lithium-disilicate crown; and (4) zirconia hybrid abutment/lithium-disilicate crown (control). The specimens were cemented to a titanium-base implant system, subjected to thermocycling and cyclic loading, and fractured in a material testing device. RESULTS The lithium-disilicate hybrid-abutment crown had significantly greater fracture load than all the other groups, which were not significantly different from each other. CONCLUSIONS Based on fracture load, the new lithium-disilicate hybrid-abutment material may serve as a viable alternative to the use of zirconia as a hybrid-abutment material.
Complication Rates and Short-Term Outcomes After Operative Hammertoe Correction in Older Patients

Background: Hammertoe deformities are the most common lesser toe deformity. To date, no studies have looked at outcomes of operative management in the geriatric population, which may be at greater risk for complications or functional compromise because of comorbidities. Methods: Data on 58 patients undergoing operative correction of hammertoe deformities were prospectively collected. Clinical outcomes were assessed using preoperative and postoperative visual analogue scale (VAS) and Short Form Health Survey (SF-36) scores with a minimum of 6-month follow-up. Patients were divided into 2 groups on the basis of age at the time of surgery: younger than 65 and 65 and older. Complication rates and mean VAS and SF-36 improvement were compared. Forty-seven patients met inclusion criteria (7 men, 40 women), with 26 patients (37 toes) in the younger cohort and 21 patients (39 toes) in the older cohort. Results: Overall, patients demonstrated significant improvement from baseline to 6 and 12 months postoperatively in VAS (P < .001 and P < .001) and SF-36 (P < .001 and P < .001) scores. Mean improvement in VAS and SF-36 scores was not significantly different between the groups at 6 and 12 months postoperatively. Complications occurred in 13.5% and 10.3% of patients in the younger and older cohorts, respectively. Conclusions: Outcomes of operative correction of hammertoe deformities in older patients were similar to outcomes in younger patients after greater than 6 months of follow-up. Overall improvement in VAS and SF-36 was statistically significant for both cohorts. There was no associated increase in complications for older patients. Level of Evidence: Level, III comparative series.
Assessment of static flood modeling techniques: application to contrasting marshes flooded during Xynthia (western France)

Abstract. This study aims to assess the performance of raster-based flood modeling methods on a wide diversity of coastal marshes. These methods are applied to the flooding associated with the storm Xynthia, which severely hit the western coast of France in February 2010. Static and semi-dynamic methods are assessed using a combination of LiDAR data, post-storm delineation of flooded areas and sea levels originating from both tide gauge measurements and storm surge modeling. Static methods are applied to 27 marshes showing a wide geomorphological diversity. It appears that these methods are suitable for marshes with a small distance between the coastline and the landward boundary of the marsh, which causes these marshes to flood rapidly. On the contrary, these methods overpredict flooded areas for large marshes where the distance between the coastline and the landward boundary of the marsh is large, because the flooding cannot be considered as instantaneous. In this case, semi-dynamic methods based on surge overflowing volume calculations can improve the flooding prediction significantly. This study suggests that static and semi-dynamic flood modeling methods can be attractive and quickly deployed to rapidly produce predictive flood maps of vulnerable areas under certain conditions, particularly for small distances between the coastline and the landward boundary of the low-lying coastal area.
Effect of atmospheric organic complexation on iron-bearing dust solubility

Abstract. Recent studies reported that the effect of organic complexation may be a potentially important process to be considered by models estimating atmospheric iron flux to the ocean. In this study, we investigated this process effect by a series of dissolution experiments on iron-bearing dust in the presence or the absence of various organic compounds (acetate, formate, oxalate, malonate, succinate, glutarate, glycolate, lactate, tartrate and humic acid as an analogue of humic like substances, HULIS) typically found in atmospheric waters. Only 4 of tested organic ligands (oxalate, malonate, tartrate and humic acid) caused an enhancement of iron solubility which was associated with an increase of dissolved Fe(II) concentrations. For all of these organic ligands, a positive linear dependence of iron solubility to organic concentrations was observed and showed that the extent of organic complexation on iron solubility decreased in the following order: oxalate >malonate = tartrate > humic acid. This was attributed to the ability of electron donors of organic ligands and implies a reductive ligand-promoted dissolution. This study confirms that among the known atmospheric organic binding ligands of Fe, oxalate is the most effective ligand promoting dust iron solubility and showed, for the first time, the potential effect of HULIS on iron dissolution under atmospheric conditions.
Physical Factors and Glomerulosclerosis

Glomerulosclerosis (GS) designates a pathological process within the glomerulus of some and perhaps all mammalian species. Laboratory rats and man have been the most studied. GS is characterized at the outset by increase in volume of the glomerular matrix of one, several or many lobules of the tuft of glomerular capillaries. This process progresses usually in association with proliferation of the mesangial cells of the affected glomerulus. The process ends with collapse of the glomerular capillaries and obliteration of Bowman’s space. In the absence of other pathology GS progresses relatively slowly, becoming evident first in a few glomeruli, the numbers increasing until as many as half or more may be found in various stages of sclerosis in the mature or old animal. Proteinuria is present and proportional to the number of affected glomeruli and the intensity of involvement.
Numerical simulation of particulate removal efficiency in venturi scrubber

Coal power plants are used extensively worldwide for electricity production due to its cheap rate. The major demerit is its adverse affect on the environment through emissions. The particulates and pollutant gases are the major ones, emitted by coal power plants. Venturi scrubber is one of those technologies that assist in simultaneous removal of particulates and toxic gases. To correctly understand and design these equipments, it is necessary to visualize the fluid dynamics inside these devices. In this regard, a numerical simulation is performed in ANSYS-CFX by using Eulerian-Lagrangian method to estimate particulate collection efficiency in the venturi scrubber. The collection efficiency is investigated at different gas and water mass flow rates. The potassium oxide (K2O) particles of one micron size with 2.35 g/cm3 density is used in simulation. Droplet diameter is also calculated in simulation by means of Cascade Atomization Breakup (CAB) model. Proper selection of breakup regime for droplet deformation in CAB model is determined by calculation of gas Weber and Ohnesorge number. Grade efficiency is calculated for throat gas velocity of 32 m/s with liquid to gas ratio of 7 l/m3. The affect of liquid to gas ratio at specific throat gas velocities on particulates removal efficiency and droplets diameter are also examined. The results shows that the increase in particulates removal efficiency occurred by increasing gas mass flow rate and liquid to gas ratio at particular gas velocities. The decrease in droplet size is observed during accession in liquid to gas ratio. Particulate removal efficiency of 99 % can be achieved at higher gas mass flow rates due to high inertial impaction parameter.
The role and relevance of mast cells in urticaria

This review presents evidence that the skin mast cell, in particular the MCTC subtype, is the primary effector cell in urticaria. Mast cells are located in the upper dermis, the ideal situation for wheal formation and sensory nerve stimulation. Increased numbers of mast cells are found in both lesional and non‐lesional skin in CSU and inducible urticaria. Mast cell degranulation in the area of wheals has been demonstrated repeatedly by light and electron microscopy. Histamine, PGD2 and tryptase are found in the venous blood draining wheal formation. The last 2 are specific for mast cells rather than basophils. Mast cell reactivity is increased in active urticaria by local inflammatory cytokines and neuropeptides. Mast cell cytokines and neuropeptides, particularly nerve growth factor, induce a Th2 type inflammation that is particularly obvious at the sites of whealing. In conclusion, autoimmunity, either of Type 1 viz. IgE antibodies to local autoallergens, or Type 2b, viz. IgG autoantibodies to IgE or its receptor, are considered to be the most frequent causes of CSU. In both cases, the mast cell is likely to be the axial cell in producing the wheals.
Intracochlear Pressure Transients During Cochlear Implant Electrode Insertion

Hypothesis: Cochlear implant (CI) electrode insertion into the round window induces pressure transients in the cochlear fluid comparable to high-intensity sound transients. Background: Many patients receiving a CI have some remaining functional hearing at low frequencies; thus, devices and surgical techniques have been developed to use this residual hearing. To maintain functional acoustic hearing, it is important to retain function of any hair cells and auditory nerve fibers innervating the basilar membrane; however, in a subset of patients, residual low-frequency hearing is lost after CI insertion. Here, we test the hypothesis that transient intracochlear pressure spikes are generated during CI electrode insertion, which could cause damage and compromise residual hearing. Methods: Human cadaveric temporal bones were prepared with an extended facial recess. Pressures in the scala vestibuli and tympani were measured with fiber-optic pressure sensors inserted into the cochlea near the oval and round windows, whereas CI electrodes (five styles from two manufacturers) were inserted into the cochlea via a round window approach. Results: Pressures in the scala tympani tended to be larger in magnitude than pressures in the scala vestibuli, consistent with electrode insertion into the scala tympani. CI electrode insertion produced a range of pressure transients in the cochlea that could occur alone or as part of a train of spikes with equivalent peak sound pressure levels in excess of 170 dB sound pressure level. Instances of pressure transients varied with electrode styles. Conclusion: Results suggest electrode design, insertion mechanism, and surgical technique affect the magnitude and rate of intracochlear pressure transients during CI electrode insertion. Pressure transients showed intensities similar to those elicited by high-level sounds and thus could cause damage to the basilar membrane and/or hair cells.