Miracle-dz/UniFAR-FTUs huggingface dataset:
Patient-specific prediction of functional recovery after stroke

Background and aims Clinical predictive models for stroke recovery could offer the opportunity of targeted early intervention and more specific information for patients and carers. In this study, we developed and validated a patient-specific prognostic model for monitoring recovery after stroke and assessed its clinical utility. Methods Four hundred and ninety-five patients from the population-based South London Stroke Register were included in a substudy between 2002 and 2004. Activities of daily living were assessed using Barthel Index) at one, two, three, four, six, eight, 12, 26, and 52 weeks after stroke. Penalized linear mixed models were developed to predict patients’ functional recovery trajectories. An external validation cohort included 1049 newly registered stroke patients between 2005 and 2011. Prediction errors on discrimination and calibration were assessed. The potential clinical utility was evaluated using prognostic accuracy measurements and decision curve analysis. Results Predictive recovery curves showed good accuracy, with root mean squared deviation of 3 Barthel Index points and a R2 of 83% up to one year after stroke in the external cohort. The negative predictive values of the risk of poor recovery (Barthel Index <8) at three and 12 months were also excellent, 96% (95% CI [93.6–97.4]) and 93% [90.8–95.3], respectively, with a potential clinical utility measured by likelihood ratios (LR+:17 [10.8–26.8] at three months and LR+:11 [6.5–17.2] at 12 months). Decision curve analysis showed an increased clinical benefit, particularly at threshold probabilities of above 5% for predictive risk of poor outcomes. Conclusions A recovery curves tool seems to accurately predict progression of functional recovery in poststroke patients.
Novel Sensitive Real-Time PCR for Quantification of Bacterial 16S rRNA Genes in Plasma of HIV-Infected Patients as a Marker for Microbial Translocation

ABSTRACT We developed a real-time PCR to quantify 16S rRNA gene levels in plasma from HIV-infected patients as a marker of microbial translocation. The assay uses shrimp nuclease (SNuc) to eliminate DNA contamination, giving high sensitivity and low variability. The 16S rRNA gene levels measured in plasma from HIV patients correlated significantly with lipopolysaccharide levels.
Smart Household Operation Considering Bi-Directional EV and ESS Utilization by Real-Time Pricing-Based DR

As the smart grid solutions enable active consumer participation, demand response (DR) strategies have drawn much interest in the literature recently, especially for residential areas. As a new type of consumer load in the electric power system, electric vehicles (EVs) also provide different opportunities, including the capability of utilizing EVs as a storage unit via vehicle-to-home (V2H) and vehicle-to-grid (V2G) options instead of peak power procurement from the grid. In this paper, as the main contribution to the literature, a collaborative evaluation of dynamic-pricing and peak power limiting-based DR strategies with a bi-directional utilization possibility for EV and energy storage system (ESS) is realized. A mixed-integer linear programming (MILP) framework-based modeling of a home energy management (HEM) structure is provided for this purpose. A distributed small-scale renewable energy generation system, the V2H and V2G capabilities of an EV together with two-way energy trading of ESS, and different DR strategies are all combined in a single HEM system for the first time in the literature. The impacts of different EV owner consumer preferences together with the availability of ESS and two-way energy trading capabilities on the reduction of total electricity prices are examined with case studies.
Orthopaedic shoulder clinic diagnosis and treatment plan audit

Purpose – The orthopaedic consultants at East Kent Hospitals NHS Trust had questioned whether the Extended Scope Practitioners (ESPs) and consultants were forming a comparable diagnosis and treatment plan. This audit aims to identify what percentage of patients received a comparable diagnosis from the ESPs and the orthopaedic consultant and to find out what percentage of patients referred from the ESP to the orthopaedic consultant for a surgical opinion underwent surgery.Design/methodology/approach – The medical notes of a sample of patients from the ESP clinic who had been referred to the orthopaedic consultant were reviewed retrospectively and the following information was documented in a table: the ESP's diagnosis, the consultant's diagnosis and whether the patient underwent surgery.Findings – The audit found a 31 per cent partially and 65 per cent fully comparable diagnosis rate between the consultant and the ESPs, and the ESPs predicted which patient would undergo surgery in 86 per cent of cases. The.
Selection and Counterselection of the rtI233V Adefovir Resistance Mutation during Antiviral Therapy

ABSTRACT Recently, we reported on three patients with chronic hepatitis B virus (HBV) infection for whom adefovir (ADF) therapy virologically failed, most likely due to a preexisting rtI233V HBV polymerase mutation. Here, we describe two further patients with chronic HBV infection who were found to develop the rtI233V mutation after initiation of ADF therapy. These patients represent the first cases known so far in which the rtI233V ADF resistance mutation evolved under persistent HBV replication during HBV therapy with ADF. Interestingly, one of the previously described patients, who was initially successfully switched from ADF to tenofovir (TDF) and became virologically suppressed subsequently, experienced a moderate but remarkable rebound of HBV viremia after switching from TDF to entecavir, due to the emergence of renal toxicity. Thus, we provide evidence for the selection and counterselection of the rtI233V ADF resistance mutation during antiviral therapy.
Renal replacement therapy in Scottish critical care units: A national audit of practices

Large randomised controlled trials show no benefit of high intensity renal replacement therapy compared to lower intensity regimens. Previous data suggest large variation in practice. This audit evaluated practices in relation to intensity of replacement therapy in critical care units across the Scottish National Health Service over a 28-day period. The mean delivered weight-adjusted effluent flow rates for continuous veno-venous haemofiltration were 29.1 (8.1 SD) ml kg−1 h−1 which was 89% of that prescribed. For continuous veno-venous haemodiafiltration, the mean delivered dose was 41.3 (7.9) ml kg−1 h−1 which was 88.4% of that prescribed. Of the eight patients undergoing intermittent haemodialysis, seven had daily treatments, whilst the eighth had four treatments in five days. The prescription and delivery of renal replacement therapy within Scottish critical care units are routinely performed at an intensity that is higher than necessary. Avoidance of excessive dose could provide important cost savings.
Two-stage repair of low anorectal malformations in girls: is it truly a setback?

Background/purposeAnorectal malformations (ARMs) affect 1 in 4000–5000 births. Low ARMs are nowadays treated in the first stage rather than at second or third stages. However, reports suggest problems with continence in these children because of wound dehiscence and infection; thus, protective colostomy may still be recommended. Colostomies do have complications, but the question is whether these disadvantages outweigh the protective effect on wound healing after anal reconstruction. The aim of this study was to define whether two-stage repair of low ARMs in girls is truly a setback or whether it is beneficial. Patients and methodsDuring the period of June 2008–June 2012, 30 female patients suffering from low ARMs were admitted to Mansoura University Children Hospital. Their ages at the time of surgery ranged from 3 to 11 months (mean age 6.2) and they were divided into two equal groups. The fistula location was defined either anocutaneous or anovestibular according to the Pena classification. The choice of management was totally randomized; thus, patients of group A underwent a two-stage posterior sagittal anorectoplasty and group B patients underwent a one-stage posterior sagittal anorectoplasty operation. Data recorded included age, fistula location, associated anomalies, operation performed, operative time, length of hospital stay, approximate cost, and postoperative complications. ResultsA comparison of data showed that treatment of patients of group A involved more time and money and they had a longer duration of hospital stay than did patients of group B. Seven patients (47%) in group A and nine patients (60%) in group B showed postoperative complications. Wound infection occurred in three patients (20%) of group A and in eight patients (53%) of group B. More importantly, two (13%) wound disruptions occurred among the three cases with wound infection in group A, whereas six (40%) disruptions occurred among the eight patients (53%) with wound infections in group B. The incidence of redo operation in group B was found to be significantly higher than in group A. Mucosal prolapse occurred in only one patient (7%) of group B. Complications related to colostomy occurred in group A only; five patients (33%) suffered skin excoriation around the stoma and one patient (7%) showed a prolapsed distal stoma loop. Constipation was noted during follow-up in five patients (33%) of group A and in six patients (40%) of group B. ConclusionTwo-stage repair of low ARM in girls is truly beneficial, as we could perform a successful operation and achieve continence in the child regardless of the complications of colostomy, which are temporary and tolerable.
The health benefits and cost effectiveness of the radon mitigation programme in NHS properties in Northamptonshire

A comprehensive radon remediation programme in NHS properties in Northamptonshire, where 11 100 staff are employed working on 83 separate sites, has been in progress since 1992, and has resulted in many locations with raised radon levels being identified and remediated. This paper considers the dose saving achieved and costs of the remediation to derive a value for the cost-effectiveness of the programme. A value of £184 000 per Man-Sievert of annual dose reduction was obtained, which is around half the figure calculated by the NRPB in its recent initiative to reduce patient doses from dental x-rays in the UK, based on cost-benefit analysis. Thus similar comprehensive radon remediation programmes in any workplace in Radon Affected Areas can be justified. The cost of this workplace programme is, however, a factor of about 4 times more expensive than the theoretical estimates for domestic radon mitigation programmes found in the literature, and the reasons for this difference are considered.
Two Mutations Associated with Macrolide Resistance in Treponema pallidum in Shandong, China

We read with interest the report by Wu et al. ([1][1]) showing that none of the 211 Treponema pallidum strains examined exhibited 23S rRNA mutations (i.e., A2058G and A2059G) associated with resistance to macrolides. Their finding suggests that azithromycin remains an appropriate alternative
Adult Invasive and Noninvasive Infections Due to Streptococcus dysgalactiae subsp. equisimilis in France from 2006 to 2010

ABSTRACT We characterized 182 Streptococcus dysgalactiae subsp. equisimilis isolates and analyzed the epidemiological data on the corresponding infections. stG6, stG485, and stG6792 were the 3 most prevalent invasive emm types among the 27 different emm types recovered. High rates of antimicrobial resistance were observed for macrolides (26.4%) and tetracycline (34.6%).
Formative Evaluation and Three-Month Follow-Up of an Online Personalized Assessment Feedback Intervention for Problem Drinkers

Background In recent years, online services for problem drinkers have been developed. This paper describes ongoing efforts to improve one of these services, the Alcohol Help Center. Objective This report summarizes new modules added to the Check Your Drinking (CYD) screener, a component of the Alcohol Help Center, to make the CYD screener more useful to periodic heavy drinkers, as well as to regular alcohol consumers. Participants’ initial reactions to the CYD screener and the changes in their drinking habits at a three-month follow-up are presented. Methods The CYD screener provides a free personalized Final Report that compares the user’s drinking to that of others in the general population of the same age, gender, and country of origin. Current alcohol consumption and demographic characteristics are collected as part of the CYD screening process. After users were presented with a customized Final Report, they were hot-linked to a volunteer feedback survey. The voluntary feedback survey asked about impressions of the CYD Final Report. Respondents agreeing to participate were sent a follow-up survey after three months. Results We recruited 388 volunteers (69% female) who were registered users of another free-to-consumer online eHealth service. Of the 343 respondents agreeing to participate in the three-month follow-up, 138 accessed the survey, and 97 provided complete data (participation rate = 40%; completion rate = 70%). Compared to moderate drinkers, current problem drinkers judged the Final Report to be more useful (34% vs. 69%, χ21 = 41.5, P < .001) and accurate (43% vs. 76%, χ21 = 36.0, P < .001). Respondents who participated in the three-month follow-up displayed reductions in drinking compared to baseline (F4,76 = 12.2, P = .001). Conclusions Improvements can still be made to make the CYD screener more relevant to specific populations, particularly periodic heavy drinkers. There is a need to further tailor algorithms that can present questions only relevant to specific populations. There also appears to be a need to further customize the Final Report for respondents who identify themselves as infrequent heavy drinkers. These improvements will be made, and a randomized controlled trial is planned to conduct a rigorous evaluation of the CYD screener as an intervention to help problem drinkers.
Nutritional Considerations in Cystic Fibrosis

Patients with cystic fibrosis (CF) have been characterized in the literature as having voracious appetites yet remaining markedly underweight for height and age. Recently, it has been recognized that the voracious appetite usually had been described at the time of diagnosis of CF and during an evaluation for failure to thrive. Calculations derived from dietary records of CF patients from various clinics have indicated that many CF patients do not maintain the voracious appetite as their disease progresses.
Evaluation of Simple and Looped Suture and New Material for Flexor Tendon Repair

Flexor tendon repair strength is proportional to the number of suture strands crossing the repair site but it is not clear if each strand needs to result from a separate pass through the tendon. We examined whether one throw of looped suture across a repair site equals two separate throws of suture and whether fewer passes with stronger material such as Fiberwire is equivalent to more passes with a comparatively weaker material such as Supramid. When evaluating the repairs for force required to generate a 2 mm gap and for gap formed at the instant prior to failure, looped suture cannot substitute for two separate passes of suture (Supramid Kessler looped vs. separate passes, 14 N vs. 35 N and 8.8 mm vs. 4.1 mm, respectively; Fiberwire Kessler looped vs. separate passes, 25 N vs. 43 N and 7.6 mm vs. 4.6 mm, respectively; all p<0.05). Two-stranded Fiberwire Kessler repair equalled four-stranded cruciate repair with Supramid for all tested parameters (force at 2 mm gap: 17 N vs. 22 N, respectively; force at failure: 42 N vs. 46 N; and gap formed prior to instant of failure: 6.9 mm vs. 5.6 mm; all p>0.05).
Screening of a Large Global Aspergillus fumigatus Species Complex Collection by Using a Species-Specific Microsphere-Based Luminex Assay

ABSTRACT A microsphere-based Luminex assay was developed and validated for rapid identification of Aspergillus fumigatus from the other species within the A. fumigatus species complex (section Fumigati). This molecular tool was then employed to screen 499 clinical A. fumigatus species complex isolates collected from multiple medical centers throughout the world with results demonstrating the exclusive presence of A. fumigatus.
Intra-articular distal ulnar fractures associated with distal radial fractures in older adults: early experience in fixation of the radius and leaving the ulna unfixed

There is no clear consensus about the best management of intra-articular distal ulnar fractures associated with distal radial fractures in older adults. We describe a treatment wherein the distal radial fractures were securely fixed with a palmar plate, leaving the associated ulnar fractures unfixed. The wrists of 14 patients with a mean age of 74 years were reviewed at an average of 18 months after surgery. The results were excellent in 11 cases and good in three, according to the modified Gartland and Werley score. All fracture sites displayed union, and there was no instability of the distal radioulnar joint. A widening of the distal radioulnar joint space was present in one wrist. Angular deformity of the distal ulnar metaphysis was seen in five wrists. This treatment could be an alternative to open reduction with internal fixation for intra-articular distal ulnar fractures in older adults.
PrefixSpan,: mining sequential patterns efficiently by prefix-projected pattern growth

Sequential pattern mining is an important data mining problem with broad applications. It is challenging since one may need to examine a combinatorially explosive number of possible subsequence patterns. Most of the previously developed sequential pattern mining methods follow the methodology of A priori which may substantially reduce the number of combinations to be examined. Howeve6 Apriori still encounters problems when a sequence database is large andor when sequential patterns to be mined are numerous ano we propose a novel sequential pattern mining method, called Prefixspan (i.e., Prefix-projected - Ettern_ mining), which explores prejxprojection in sequential pattern mining. Prefixspan mines the complete set of patterns but greatly reduces the efforts of candidate subsequence generation. Moreover; prefi-projection substantially reduces the size of projected databases and leads to efJicient processing. Our performance study shows that Prefixspan outperforms both the Apriori-based GSP algorithm and another recently proposed method; Frees pan, in mining large sequence data bases.
New Methods for Detection of Campylobacters in Stool Samples in Comparison to Culture

ABSTRACT Campylobacter species, especially Campylobacter jejuni and Campylobacter coli, are a major cause of human bacterial enteritis. Current detection in stools is done essentially by culture on selective and nonselective media with filtration. These methods were compared to 2 molecular biology methods, an in-house real-time PCR and a multiplex PCR named Seeplex Diarrhea ACE Detection, and 3 immunoenzymatic methods, Premier Campy, RidaScreen Campylobacter, and ImmunoCard Stat! Campy. Out of 242 stool specimens tested, 23 (9.5%) fulfilled the positivity criteria, i.e., they were positive by one or both culture methods or, in case of a negative culture, by a positive molecular method and a positive immunoenzymatic method. The striking feature of this study is the low sensitivity of culture, in the range of 60%, in contrast to immunoenzymatic and molecular tests.
Language models for information retrieval

One of the major challenges in the field of information retrieval (IR) is to specify a formal framework that both describes the important processes involved in finding relevant information, and successfully predicts which techniques will provide good effectiveness in terms of accuracy. A recent approach that has shown considerable promise uses generative models of text (language models) to describe the IR processes. We briefly review the major variations of the language model approach and how they have been used to develop a range of retrieval-related language technologies, including cross-lingual IR and distributed search. We also discuss how this approach could be used with structured data extracted from text.
Evidence for Clonal Dissemination of the Serotype K1 Klebsiella pneumoniae Strain Causing Invasive Liver Abscesses in Korea

ABSTRACT Seventy-three liver abscess isolates of serotype K1 Klebsiella pneumoniae from a nationwide collection in Korea were genotypically characterized using pulsed-field gel electrophoresis and multilocus sequence typing. We found that serotype K1 K. pneumoniae strains that caused liver abscesses in Korea were genotypically related and that most were sequence type 23.
Presence of Genes Encoding the Panton-Valentine Leukocidin Exotoxin Is Not the Primary Determinant of Outcome in Patients with Complicated Skin and Skin Structure Infections Due to Methicillin-Resistant Staphylococcus aureus: Results of a Multinational Trial

ABSTRACT The role of Panton-Valentine leukocidin (PVL) in determining the severity and outcome of complicated skin and skin structure infections (cSSSI) caused by methicillin (meticillin)-resistant Staphylococcus aureus (MRSA) is controversial. We evaluated potential associations between clinical outcome and PVL status by using MRSA isolates from patients enrolled in two large, multinational phase three clinical trials assessing telavancin for the treatment of cSSSI (the ATLAS program). MRSA isolates from microbiologically evaluable patients were genotyped by pulsed-field gel electrophoresis (PFGE) and PCR for pvl and 31 other putative virulence determinants. A single baseline pathogen of MRSA was isolated from 522 microbiologically evaluable patients (25.1%) among 2,079 randomized patients. Of these MRSA isolates, 83.2% (432/519) exhibited the USA300 PFGE genotype and 89.1% (465/522) were pvl positive. Patients with pvl-positive MRSA were more likely than those with pvl-negative MRSA to be young, to be North American, and to present with major abscesses (P < 0.001 for each). Patients were significantly more likely to be cured if they were infected with pvl-positive MRSA than if they were infected with pvl-negative MRSA (91.6% versus 80.7%; P = 0.015). This observation remained statistically significant after adjustment for presence of abscess, fever, or leukocytosis; infection size; diabetes; patient age; and study medication received. The fnbA, cna, sdrC, map-eap, sed, seg, sei, sej, SCCmec type IV, and agr group II genes were also associated with clinical response (P < 0.05). This contemporary, international study demonstrates that pvl was not the primary determinant of outcome in patients with MRSA cSSSI.
A lactoferrin-derived peptide (PXL01) for the reduction of adhesion formation in flexor tendon surgery: an experimental study in rabbits

Injuries to flexor tendons can lead to loss of finger function after healing due to adhesion formation. The aim of this study was to assess the efficacy and safety of the new peptide, PXL01, in the prevention of peritendinous adhesions. The effect of a single intraoperative administration of PXL01 in sodium hyaluronate on mobility of the affected digit after surgery was assessed in a rabbit model by measuring total active motion, metatarsophalangeal–claw distance and resistance to bending the digits. Load-to-failure testing was done in the same specimens to assess tendon healing. The results demonstrated that a single application of PXL01 in sodium hyaluronate significantly improved mobility of the treated digits compared with the digits in which the same surgery was carried out but no treatment was provided. No negative effects on tendon healing were observed in connection with the treatment.