Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of ozone and ND:YAG laser pretreatment on bond strength of self-etch adhesives to coronal and root dentin.

OBJECTIVES The aim of this study was to evaluate the effects of two different disinfection treatments--ozone and Nd:YAG laser application--on shear-bond strength (SBS) of self-etch adhesives to coronal and root dentin. MATERIALS AND METHODS Sixty extracted human canines were ground flat, exposing the coronal and root dentin surfaces, and randomly divided into three groups. The surfaces were untreated (Control) or treated with ozone (HealOzone, KaVo) or Nd:YAG laser (Fidelis III, Fotona). Coronal and root dentins of 10 teeth of each group were treated with a two-step self-etch adhesive (Clearfil SE Bond, Kuraray Medical; SE), whereas the remaining 10 teeth were treated with a one-step self-etch adhesive (Clearfil Tri-S Bond, Kuraray Medical; S3). A resin composite (Clearfil Majesty Esthetics, Kuraray Medical) was then placed, and SBS was tested with a universal testing machine. Failure modes were determined under a stereomicroscope. The mean SBS values of each group were calculated, and data were subjected to statistical analysis (p = 0.05). RESULTS For the coronal dentin, Control/SE showed significantly higher values than Control/S3, Ozone/S3, and Nd:YAG/S3. Although Ozone/SE showed significantly higher values than Nd:YAG/S3 (p < 0.05), the differences within the other groups were not significant for the root dentin (p > 0.05). Comparison of two dentin substrates in each group did not show any significant difference except for Control/SE, in which coronal dentin showed higher SBS. The failure modes of all groups were mainly adhesive. CONCLUSION Pretreatments with Ozone or Nd:YAG laser did not impair the SBS of both of the self-etch adhesives used to coronal and root dentin.
Cord Blood Oxidative Stress Markers Correlate With Birth and Placenta Weight

Background: Oxidative stress injury has been linked with some clinical conditions in newborn. This cannot be readily measured. Measuring placenta and birth weight along with other features may help in predicting likelihood of oxidative stress injury babies have suffered. Aim : to measure birth and placenta weight of new born babies as well as determining cord blood total antioxidant status and malondialdehyde (product of oxidant injury) Methods: Study site was labour ward of Ladoke Akintola University of Teachnology Teaching Hospital, Osogbo, Nigeria. Sixty four term newborn babies were recruited into the study. Plasma extracted from cord blood of subjects was used for the laboratory determination of total antioxidant status, malondialdehyde and uric acid. Total antioxidant status and malondialdehyde were measured using methods of Koracevic et al and Satoh et al respectively. Uric acid was measured by enzymatic method. Results: There were positive correlations between placenta weight and TAS(r=0.115;p>0.05), between placenta weight and Uric acid(r=0.075;p>0.05), between birth weight and TAS(r= 0.233,p=0.064), between birth weight and Uric acid(r=0.172;p>0.05). There were significant negative correlations between placenta weight and MDA(r=-0.25;p
PCAF Interacts with Tax and Stimulates Tax Transactivation in a Histone Acetyltransferase-Independent Manner

ABSTRACT Recent studies have shown that the p300/CREB binding protein (CBP)-associated factor (PCAF) is involved in transcriptional activation. PCAF activity has been shown strongly associated with histone acetyltransferase (HAT) activity. In this report, we present evidence for a HAT-independent transcription function that is activated in the presence of the human T-cell leukemia virus type 1 (HTLV-1) Tax protein. In vitro and in vivo GST-Tax pull-down and coimmunoprecipitation experiments demonstrate that there is a direct interaction between Tax and PCAF, independent of p300/CBP. PCAF can be recruited to the HTLV-1 Tax responsive element in the presence of Tax, and PCAF cooperates with Tax in vivo to activate transcription from the HTLV-1 LTR over 10-fold. Point mutations at Tax amino acid 318 (TaxS318A) or 319 to 320 (Tax M47), which have decreased or no activity on the HTLV-1 promoter, are defective for PCAF binding. Strikingly, the ability of PCAF to stimulate Tax transactivation is not solely dependent on the PCAF HAT domain. Two independent PCAF HAT mutants, which knock out acetyltransferase enzyme activity, activate Tax transactivation to approximately the same level as wild-type PCAF. In contrast, p300 stimulation of Tax transactivation is HAT dependent. These studies provide experimental evidence that PCAF contains a coactivator transcription function independent of the HAT activity on the viral long terminal repeat.
Evaluación de un Detector de Complejo QRS Basado en la Wavelet de Haar, Usando las Bases de Datos MIT–BIH de Arritmias y Europea del Segmento ST y de la Onda T

SE DESARROLLO E IMPLEMENTO COMO FILTRO DIGITAL RECURSIVO PARA SER USADO EN UN MONITOR ELECTROCARDIOGRAFICO DE ISQUEMIA CARDIACA, UN DETECTOR EN LINEA DE COMPLEJOS QRS BASADO EN LA WAVELET DE HAAR. SE DETERMINO EL DESEMPENO DEL DETECTOR USANDO LOS ARCHIVOS DISPONIBLES EN PHYSIONET DE LAS BASES DATOS MIT-BIH DE ARRITMIAS Y EUROPEA DEL SEGMENTO ST Y DE LA ONDA T. EL DETECTOR RESULTANTE ES RAPIDO EN LA EJECUCION, FACIL DE IMPLEMENTAR, NO ACUMULA ERROR Y PRESENTO TASAS DE ERROR DEL 1.19% Y 0.19% AL SER EVALUADO CON LAS BASES MENCIONADAS. MEDIANTE EL COEFICIENTE DE CORRELACION Y LA DIFERENCIA MAXIMA EN AMPLITUD, SE ESTIMO LA DISTORSION CAUSADA POR LOS ERRORES DE DETECCION EN LA MORFOLOGIA DE LATIDOS PROMEDIO. ASI, SE CONCLUYO QUE EL DETECTOR PROPUESTO ES APROPIADO PARA SER USADO EN UN SISTEMA DE MONITOREO DE ISQUEMIA CARDIACA Y, EN GENERAL, EN CUALQUIER SISTEMA BASADO EN LATIDOS PROMEDIO
Becoming Roman, staying Greek: Culture, identity and the civilizing process in the Roman East

The nature, and indeed the reality, of Romanization in the east is controversial. One of the most influential accounts of Romanization in the western provinces notes that ‘by contrast, where Greek was already the language of culture, of government and of inter-regional trade, the Romans carried further the process of Hellenization … in general what was specifically Latin in the common civilization of the empire made little impact in the east’, the exceptions being the influence of Roman law and the popularity of gladiatorial games. That verdict endorsed the view that ‘the emperors made no attempt to romanise the Greek speaking provinces’, which saw the foundation of cities as a continuance of Hellenistic royal practice, and which regarded the establishment of the rare eastern colonies as motivated by practical considerations rather than any attempt at encouraging cultural assimilation. More recently, a fuller survey of exceptions to this general rule nevertheless concluded that ‘On the one hand, the culture and identity of the Greek east remained fundamentally rooted in the Classical past. On the other hand, the visible presence of Rome, outside those zones where the legions were stationed, was extremely slight. ’
Is peritoneal dialysis adequate for hypercatabolic acute renal failure in developing countries?

BACKGROUND Peritoneal dialysis (PD) is a therapeutic option for acute renal failure (ARF) in developing countries, despite concerns about inadequacy. Shorter and more efficient tidal peritoneal dialysis (TPD) was compared with continuous equilibrating peritoneal dialysis (CEPD) therapy in ARF by using their adequacies as accepted standards and analyzing the solute reduction indices (SRI). METHODS A prospective, randomized crossover trial was performed in patients with mild to moderate hypercatabolic ARF who were assigned to CEPD and TPD therapy after an adequate washout period. Solute clearances (Kt/V, normalized creatinine clearances) were compared to NKF guidelines. Potassium and phosphate clearances, dextrose absorption, protein losses and costs were compared. Kt/V was compared to SRIdialysate, SRIKt/V. RESULTS Eighty-seven patients with ARF received 236 sessions of dialysis (118 in each treatment). TPD resulted in higher clearances of solutes than CEPD (creatinine and urea clearances in mL/min of 9.94 +/- 2.93, 6.74 +/- 1.63 and 19.85 +/- 1.95, 10.63+/- 2.62, respectively, P=0.001). TPD and CEPD normalized creatinine clearances (L/week/1.73 m2 BSA) and Kt/V values were 68.5 +/- 4.43, 58.85 +/- 2.57 and 2.43 +/- 0.87, 1.80 +/- 0.32, respectively. CEPD did not meet standards of adequacy. TPD resulted in greater potassium and phosphate clearances, less dextrose absorption and was less expensive. CEPD resulted in less protein loss. Kt/V corresponded to SRIdialysate 0.88 +/- 0.12 (P=0.076). CONCLUSION TPD produced higher solute clearances in less time with greater protein loss. CEPD just fell short to meet the dialysis adequacy standard. However, both TPD and CEPD are reasonable options for mild-moderate hypercatabolic ARF. Kt/V appropriately estimates solute removal in PD.
The Behavioral Immune System

Human psychology is characterized by a motivational system (the “behavioral immune system”) that appears to have evolved as a means of providing prophylactic protection against pathogen infection. This chapter provides an overview of research on the behavioral immune system, describing why it evolved, how it operates, and its many implications—some obvious and some not—for human cognition and human behavior. This overview is presented in the form of 12 “things you need to know” that, collectively, summarize the scope of contemporary research on the behavioral immune system, and provide a foundation for thinking critically about it. Keywords: behavioral immune system; disease; disgust; evolution; social cognition; social interaction
Impact of Magnesium Intake and Supplementation in Improving the Quality of Life in Type II Diabetes Mellitus-Patients

In recent years, it has been widely accepted that people tend to consume diet that has no nutritive value, leading to nutrient deficiencies of which magnesium deficiency seems to hold pole position. This deficiency is associated with various disorders of which diabetes mellitus has recently been gaining importance. Diabetes Mellitus (T2DM )is a complex, heterogeneous and polygenic metabolic disease where the body fails to utilize insulin, leading to an altered glucose homeostasis. Its pathogenesis involves complex interactions between genetic and environmental factors (Gupta, 2012). The paper focuses on assessing the usefulness of intake of magnesium rich foods and its supplementation in delaying the complications of Diabetes Mellitus and improving the quality of life of the patient. Experimental data has been collected from diabetic patients in order to analyse the levels of magnesium. Analysis was done using SPSS version 16.0. There is a positive correlation between Mg intake, suggesting that the Mg supplementation and intake can delay the development of type 2 DM and improve their quality of life.
Movement impairment: Focus on the brain

The saying “mens sana in corpore sano” has a particular resonance these days because, for the majority who have a very sedentary occupation, the everyday rhythms of life do not compel us to do much physical exercise. Recently published data indicate that exercise can counteract the effects of neurological diseases such as Alzheimer's disease and have prompted research on the beneficial effects of movement on the brain and brain neurogenesis. This might lead us to hypothesize that the absence or reduction of movements, especially those with antigravity effects, could induce a deterioration of the brain. This Review discusses current knowledge of the relationship between neurogenic capacity and the lack of motor activity in human and animal models. © 2016 Wiley Periodicals, Inc.
INFLUENCE OF SOME OPERATIVE AND POSTOPERATIVE FACTORS ON CAPSULAR CONTRACTURE AROUND BREAST PROSTHESES

In a follow-up of 490 patients with breast implants, neither the size of the prosthesis nor the nature of the surgical procedure (simple augmentation mammaplasty or after subcutaneous mastectomy) increased the incidence of capsular contracture. Hematoma or infection were followed by a higher incidence of capsular contracture. Drainage with suction and the instillation of steroid around the prostheses seemed to be effective in reducing the incidence of capsular contracture. In the steroid-treated group, the need for open surgical treatment was reduced. The recurrence rate after closed capsulotomy, or open capsulotomy, was not significantly different from that following the more extensive procedure of capsulectomy.
Making a Necessity of Virtue: Aristotle and Kant on Virtue

1. A new dialogue 2. The emotional structure of Aristotelian virtue 3. A brief stoic interlude 4. The passional underpinnings of Kantian virtue 5. The shared voyage 6. Aristotelian particularism 7. Making room for practical wisdom in Kantian ethics 8. Perfecting Kantian virtue: discretionary latitude and superlative virtue.
Assessment of fetal canine cardiac myocyte survival in a dual‐side flow bioreactor with modeled hypoxia/reperfusion injury

The present study introduces a new experimental model of hypoxia/reperfusion injury using a newly developed bioreactor system. The injury is introduced and kept localized via fluid dynamic manipulation. Using low Reynolds number fluid flow, regions of the culture can be injured while maintaining physiological conditions in the remaining culture. This approach enables both normal and injured cells within the same monolayer to be investigated side‐by‐side. The current study evaluated the ability of the model to induce localized reperfusion injury in a monolayer of fetal canine cardiomyocytes (FCCs). Significant apoptosis was found in the hypoxia/reperfusion‐injured but not normal‐flow regions of the myocyte cultures. The model holds the potential to help elucidate the fundamental mechanisms of hypoxic/reperfusion insults in myocardium. Biotechnol. Bioeng. 2009;103: 199–206. © 2008 Wiley Periodicals, Inc.
Iron deficiency anaemia and febrile convulsions: case-control study in children under 2 years

Febrile convulsions are the most common type of seizure and occur in 2-4% of all children.1 A family history of convulsions; maternal smoking; and alcohol consumption during pregnancy have been associated with febrile seizures,2 3 but the risk factors remain largely unknown. Iron is involved in the metabolism of several neurotransmitters, and monoamine and aldehyde oxidase are reduced in iron deficiency anaemia4, which is common during the second and the third year of life and has been associated with behavioural and development disturbances.5 Thus we investigated the association between iron deficiency anaemia and febrile seizures by a case-control study. All 156 children …
Development of a framework for the e-education of educators of special groups aiming to improve their compatibility with their learners

En las sociedades multiculturales modernas la diversidad es una caracteristica que se extiende incuestionablemente a la educacion. Educadores y estudiantes de diferentes culturas y etnias, con diferentes origenes linguisticos y sociales tienen un punto de encuentro e interaccion en los procedimientos educativos. En la educacion multicultural el papel del profesor es primordial para potenciar o no a los estudiantes en la clase, por lo que es muy importante mejorar las capacidades docentes del formador a este respecto si se desea conseguir la igualdad educativa. Esto cobra mayor relevancia aun cuando los educadores se hacen cargo de grupos espaciales, es decir, de cualquier grupo social cuyas caracteristicas (sociales, culturales, etnicas, linguisticas, fisicas, etc) sean causa de exclusion social, marginalizacion o estigmatizacion de sus miembros (inmigrantes, gitanos, ex-convictos, ex-adictos o personas con necesidades especiales). En la educacion de grupos especiales la compatibilidad entre educadores y educandos, o lo que es lo mismo, el nivel de conocimiento y aceptacion del grupo de discentes y la actitud positiva hacia el mismo afecta directamente a la eficiencia y exito del procedimiento educativo. Por otro lado, y dado el auge de las nuevas tecnologias en la educacion con el potencial que esto conlleva, la utilizacion de las mismas para conducir programas educativos personalizados ha llegado a ser una practica globalmente adoptada. Esto permite que la personalizacion se adecue a las necesidades del educador en cualquier momento y lugar y que se puedan reducir costes asociados a la educacion del educador. En este documento se presenta un marco (denominado ESG) para la educacion a traves de medios electronicos de los educadores de grupos especiales para la mejora de su compatibilidad con los educandos. El marco ESG se sustenta tanto en la tecnologia educativa como en la educacion multicultural y la educacion de adultos, combinando elementos necesarios de todos estos campos. El marco ESG esta basado en el modelo de diseno instruccional ADDIE (Analysis, Design, Development, Implementation, Evaluation) con la adicion de una fase nueva: Mantenimiento de la red de la comunidad educativa. El marco ESG proporciona para cada fase directrices dinamicas, flexibles y claras que pueden ser seguidas por disenadores, desarrolladores, administradores y educadores, optimizando el aprendizaje electronico personalizado y dotando de una educacion efectiva a los educadores de grupos especiales. Para validar el marco ESG se ha llevado a cabo una aplicacion piloto con educadores de un grupo de personas de raza gitana en Grecia. La evaluacion del curso piloto ha probado que el marco ESG es eficiente y funcional para la mejora de la compatibilidad entre educadores y estudiantes y que ofrece la posibilidad mediante el uso de tecnologias de e-learning de una personalizacion de los programas educativos de acuerdo a las necesidades del educador independientemente del lugar y momento en el que se requieran las acciones formativas.
Picumeterol: dissociation of improvement in lung function and reduction of airways hyperresponsiveness in asthmatics.

AIMS The new potent and selective beta 2-adrenoceptor agonist, GR 114297A (picumeterol) is the R-enantiomer of the racemic form, GR 63411B. Picumeterol has been shown to produce long-lasting relaxation of airways smooth muscle both in vitro and in vivo. We assessed the intrinsic activity of picumeterol by increasing intracellular levels of c-AMP and compared this with isoprenaline and salbutamol. METHODS In human atopic asthmatics, we have investigated the duration of action and efficacy of picumeterol and GR 63411B with regard to improvement in resting lung function (i.e. FEV1) and airways responsiveness (i.e. PC20) to methacholine (MCh). The study design consists of two clinical parts each for one drug. Different asthmatics participated in the two studies, seven in the first part and eight in the second part. In human bronchial smooth muscle cells in vitro, we have investigated the intrinsic activity of picumeterol in increasing intracellular levels of cyclic AMP and compared it with isoprenaline and salbutamol. RESULTS In vivo, both drugs caused bronchodilatation with similar potency, but, their effects were short-lasting. Despite their bronchodilator activity, neither drug improved PC20, when compared with placebo. In vitro, picumeterol was found have intrinsic activity lower than the other beta 2-adrenoceptor agonists tested. CONCLUSIONS In the clinical studies, the bronchodilator potencies of picumeterol and GR 63411B were similar. However, both drugs were short-acting, which is at odds with their activity in vitro. Our data suggest that these compounds display dissociation between bronchodilator activity and protection against MCh-induced bronchoconstriction. These findings may be explained by low intrinsic activity and need further conformation.
Sermaye Yapisi Ile Isletme Performansi Arasindaki Iliski: Gida Sektorunde Bir Uygulama

Sermaye yapisi kararlari ulkemizde ve tum dunyada isletmeler icin yasamsal kararlari ifade eder. Optimal sermaye bilesimine ulasabilmek icin, isletmeler cesitli analizler yaparak sermaye kombinasyonlari olustururlar. Sermaye yapisi kararlariyla ilgili sorunlar; firmalarin finansal kaynaklarinin turleri, oranlarinin ne olacagi, agirliklarinin zaman icindeki degisimleriyle ilgilidir. Isletmelerin olusturdugu optimal sermaye bilesimleri; firma gelirlerinin artisini, rekabetci ortamlara karsi koyabilmeyi, isletme performansi ve karliliginin yukselisini saglayacaktir. Karlilik, sermaye yapisi bilesimi ve performans iliskisini analiz etmek amaciyla IMKB’da kayitli 22 sirketin 6 yillik bilanco ve gelir tablosu verilerinden yararlanilarak, isletme pasifindeki borclarin ozsermaye karliligi ile iliskisi irdelenerek isletmelerin finansal performanslari arastirilmistir. Modellere iliskin katsayi tahminlerinde Genellestirilmis En Kucuk Kareler Yontemi-GEKK (Generalized Least Square-GLS) benimsenmistir. Arastirmada havuzlanmis (pooled) veri seti kullanildigindan; yatay-kesit verilerinden kaynaklanabilecek degisen varyans sorunu, degiskenlerin kendi standart sapmalarina bolunerek agirliklandirilmasi yoluyla; zaman serisi verilerinden kaynaklanabilecek otokorelasyon sorunu da modellere AR sureci eklenerek giderilmistir.
An unusual variant of multiple endocrine neoplasia syndrome: a case report

A case of multiple endocrine neoplasia syndrome (MEN) in a 57‐year‐old woman with multiple endocrine tumours involving the pancreas, parathyroid and thyroid glands is reported. An unusual feature was the presence of collision tumours in the pituitary and adrenal. In the pituitary there were adenomas and a meningioma whereas in the adrenal there was a carcinoma along with a myelolipoma. Such collision tumours in the pituitary and adrenal as components of MEN syndrome have not been previously described.
Comparative nephrotoxicity of gentamicin and tobramycin: pharmacokinetic and clinical studies in 201 patients

A total of 201 critically ill patients were studied during 267 courses of gentamicin or tobramycin treatment (139 gentamicin courses and 128 tobramycin courses). Of these 267 courses, pharmacokinetic and clinical data were obtained for 240 (120 gentamicin and 120 tobramycin). The data collected for pharmacokinetic analysis included measurements of serial blood and urine levels, urinary excretion of beta 2-microglobulin, protein levels, and granular casts. A two-compartment model was used to assess tissue accumulation, and in 89 courses the predicted accumulation was confirmed by cumulative urine collection or postmortem tissue analysis. As groups, the patients given gentamicin and tobramycin did not differ in age, weight, creatine clearance, total dose given, duration of treatment, initial aminoglycoside through serum levels, number of dosage adjustments, concurrent use of furosemide, or concurrent cephalosporins. Previous aminoglycoside treatment (usually gentamicin) had occurred more frequently in the tobramycin treated patients (P less than 0.01), and more males than females received tobramycin (P less than 0.05). Pharmacokinetic assessments of renal damage were based on both changes in glomerular filtration rate (serum creatinine levels, creatinine clearance) and renal tubular damage (beta 2-microglobin, casts), but only patients with elevated aminoglycoside tissue levels leading to renal tubular damage and subsequent creatinine clearance decreases were considered to have experienced aminoglycoside nephrotoxicity. In the pharmacokinetic analysis of nephrotoxicity, 29 gentamicin courses (24%) and 12 tobramycin courses (10%) were complicated by nephrotoxicity (P less than 0.01). The 201 study patients were also evaluated independently for clinical nephrotoxicity (defined as a serum creatinine level increase of 0.5 mg/dl or more). Clinical nephrotoxicity occurred at rates of 37% in the gentamicin-treated group and 22% in the tobramycin-treated group (P less than 0.02). In these similar groups of critically ill patients, tobramycin was less nephrotic than gentamicin.