Miracle-dz/UniFAR-FTUs huggingface dataset:
Readmissão Hospitalar por Insuficiência Cardíaca em um Hospital de Ensino do Interior do Estado de São Paulo-SP*

Estudo descritivo retrospectivo de pacientes readmitidos por insuficiencia cardiaca cronica, com o objetivo de quantificar as taxas de readmissao hospitalar nao planejada em ate 30 dias e fatores possivelmente associados a readmissao. As taxas de readmissao hospitalar em 2010 e 2011 foram de 3,91% e 2,41%, respectivamente, sendo a media de tempo ate a readmissao de 14,5±7,1 dias. A etiologia mais frequente da insuficiencia cardiaca foi a doenca valvar, seguida da hipertensao arterial. As mulheres foram mais acometidas e 96% dos pacientes foram readmitidos em decorrencia da persistencia ou recorrencia do episodio que motivou a admissao inicial. Nao foram obtidos dados satisfatorios quanto as possiveis causas que teriam levado a persistencia ou recorrencia do episodio de doenca.
Hoxa5 Promotes Adipose Differentiation via Increasing DNA Methylation Level and Inhibiting PKA/HSL Signal Pathway in Mice

Background/Aims: Impaired adipogenesis may be the underlying cause in the development of obesity and type II diabetes. Mechanistically, the family of Homeobox transcription factors is implicated in the regulation of adipocyte fate. Hoxa5 is highly expressed in adipocytes, and its mRNA expression is decreased during differentiation. However, the function of Hoxa5 in adipose tissue has been poorly understood. The aim of this study is to unveil the role of Hoxa5 on adipocyte differentiation and its underlying mechanisms. Methods: Quantitative real-time PCR (qPCR) and western blot were performed to determine Hoxa5 expression in primary adipocytes and in adipose tissues from mice. Lipid accumulation was evaluated by bodipy staining. Dual luciferase assay was applied to explore the transcription factor of Hoxa5 and the transcriptional target gene modulated by Hoxa5. All measurements were performed at least for three times at least. Results: A significant reduction of Hoxa5 expression was observed in adipose tissue of High Fat Diet (HFD) induced obesity mice. We determined Hoxa5 increased adipocytes differentiation and mitochondrial biogenesis in adipocytes in vitro. CEBPβ was determined a transcription factor of Hoxa5 and inhibited methylation level of Hoxa5 by combining on the promoter of Hoxa5. Importantly, we found Fabp4, a known positive regulator of adipocytes differentiation, was transcriptional activation by Hoxa5. In addition, Hoxa5 promotes adipocytes differentiation by inhibiting PKA/HSL pathway. Conclusion: Our study demonstrated the promoting role of Hoxa5 in adipocytes differentiation and therefore bringing a new therapeutic mean to the treatment of obesity and type II diabetes.
Degree of synovitis on MRI is correlated with histological and macroscopic features of synovial tissue inflammation in knee osteoarthritis

Background and objectives Synovitis is often present on MRI of OA knees and is an important determinant of pain. To better understand the nature of synovitis seen on MRI the authors compared microscopic and macroscopic features of synovial tissue inflammation with synovitis grade on contrast enhanced (CE) MRI. Methods and methods Twenty-two patients (mean age 61±7 years, 73% women, mean BMI 30±5 kg/mm2) with symptomatic radiographic knee OA attending the rheumatology outpatient clinic were included. Arthroscopy of the index knee was performed and macroscopic features (neovascularisation, villi, fibrin and hyperplasia) were scored (0–4). Furthermore, 15–20 synovial biopsies per knee were obtained. After H&E staining, synovial tissue samples were microscopically scored on features: synovial lining layer hyperplasia/enlargement, activation of resident cells/stroma and degree of inflammatory infiltrates. Each feature was scored from 0–3 and a total sum score per patient was devised. Mean total scores (0–9) by three observers were used. Saggital and axial T1-weighted CE MRI images (3T) were used to semi quantitatively score synovitis at 11 different sites according to Guermazi et al, ranging from 0–22.1 Self reported pain was assessed by visual analogue scale (VAS, 0–100). Pearson correlations adjusted for age were used for correlation between total histology synovitis score and total MRI score. Spearman ρ correlations were used for correlation between total histology score and macroscopic features. Both were calculated by SPSS 16.0. Results The mean (SD) synovitis score on MRI was 7.8 (3.9), representing a mild synovitis and mean (SD) histology score was 2.1 (1.5). Median (range) score of macroscopic features (0–4) were 2.0 (1.0–4.0) for neovascularisation, 1.0 (0.0–3.0) for hyperplasia, 2.0 (0.0–4.0) for villi and 2.0 (0.0–3.0) for fibrin. Synovitis score on MRI correlated significantly with microscopic synovitis score (r=0.5, p=0.019] and macroscopic neovascularisation score (r=0.6, p=0.002) and hyperplasia (r=0.4, p=0.40). Furthermore statistically significant correlation between microscopic synovitis score and macroscopic neovascularisation (r=0.5, p=0.012) existed. No significant correlations with VAS pain were seen. Conclusions Synovitis severity on T1 weighted CE MRI images is significantly correlated with both macroscopic and microscopic features of synovitis in patients with knee OA. No association with severity of pain was seen. Therefore, CE MRI evaluation is a reliable, non invasive way to determine synovitis severity in OA patients.
Response to O’Connell and Colleagues

In our prospective study of 31 lung-transplanted patients, we found a decline in measured glomerular function of 35% and 47% 1 and 12 weeks posttransplantation, respectively. Risk factors for this rapid decline were time and acute renal failure within 2 weeks posttransplant, perioperative use of heart and lung machine, use of ephedrine and older age. These changes were found in all patients and 50% of all observations were very close to the mean values. The limited number of CF patients (n = 7) did not allow for any comparisons with non-CF patients (3). In our previous longitudinal study of renal function of 390 lung-transplanted patients with the same accurate isotope method, we found that the CF patients experienced a more rapid decline at 6 months posttransplantation compared with patients with chronic obstructive pulmonary disease and alpha-1-antitrypsin deficiency. We also demonstrated that the onset of K/DOQI Stage 5 Chronic Kidney Disease was associated with a significant increase in the risk of death posttransplantation. However, when we analyzed the patients receiving pretransplant antihypertensive or insulin therapy then 75% of the patients receiving insulin were CF patients (4). This is in agreement with other groups (1,5) indicating that the association of CF with a decline in renal function may have masked the importance of pretransplant diabetes as a risk factor for a more rapid decline. This is therefore an important factor to include in the assessment of the accelerated decline in renal function in these vulnerable patients and the importance of glycemic and blood pressure control and treatment should be an essential part of the posttransplant monitoring.
Oral Toxicity of 1,2-Dithiole-3-Thione, a Potential Cancer Chemopreventive Agent, in the Rat

This study examined the toxicity of 1,2-dithiole-3-thione (D3T) in rats following 14 days of daily oral (gavage) administration. D3T, an extensive inducer of hepatic phase II drug-metabolizing enzymes, has demonstrated cancer preventive efficacy in rodent models of tumorigenesis and is a candidate drug for cancer prevention. Male and female CD rats (5/sex/dose group) received D3T at dose levels of 0 (corn oil vehicle control), 2, 6, 20, and 60 mg/kg/day. Oral administration of D3T for 14 days at 20 mg/kg/day resulted in decreased activity, lethargy, rough coat, and piloerection, and toxicologically significant lesions in the stomach, characterized by apoptotic necrosis and hyperplasia of the glandular mucosa. Administration of D3T at 60 mg/kg/day produced anemia in females, decreased body weight gain in males, and increased vacuolation of adrenal cortical cells. Increased liver weights, vacuolation of hepatocytes, and serum chemistry changes, indicative of altered liver function, were observed at 6 mg/kg/day, which were likely due to a pharmacologic effect of D3T on the liver and not considered to be toxicologically significant. Under the conditions of the study, the no-observed-adverse effect level (NOAEL) was 6 mg/kg/day.
Good intentions: teaching and specialist support staff perspectives of student disclosure of mental health issues in post-secondary education

This article reports findings from a qualitative case study, as part of which staff perspectives of student disclosure of mental health issues in an Australian post-secondary vocational education setting were explored. Twenty teaching and specialist support staff from four vocational education and training institutions participated in individual semi-structured interviews. Institutional policies and practices related to the management of disability at each site provided contextual information relevant to the staff experience. All data were analysed thematically. Staff participants strongly supported student disclosure of mental health issues. Staff linked the likelihood of course success for students experiencing mental illness with disclosure and the implementation of educational supports. Findings draw attention to subtle differences in constructions of student disclosure reported by the specialist support staff and the teachers: differences in perspective which were consistent across locations. This study highlights the influence of personal experience of mental illness and institutional processes for educational adjustment on staff perspectives of student disclosure. Implications of the current practices in post-secondary education student support services are discussed. Further research on disclosure beliefs among teachers and specialist support staff, in a wider range of educational settings, would allow for a deeper exploration of issues raised by this study.
Predicting Participation in Psychiatric Randomized Controlled Trials: Insights From the STEP-BD.

OBJECTIVE Differences between patients who do and do not participate in randomized controlled trials (RCTs) could diminish the generalizability of results. This study examined whether RCT participants differ from non-RCT participants who are recruited from the same patient and provider population. METHODS The Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) was an observational study in which participants also could enroll in an RCT during exacerbations of acute depression. The odds that a patient was enrolled in the STEP-BD acute depression RCTs (pharmacotherapy or psychotherapy) were estimated by fitting logistic regression models to STEP-BD participants with acute bipolar depression (total N=2,222; RCT, N=413; observational arm, N=1,809). Predictor variables included demographic characteristics, clinical information (including severity scales and comorbidities), and study site. The extent to which site determined RCT participation was estimated by using the area under the receiver operating characteristic curve (AUC). RESULTS RCT participation was associated with having no insurance (odds ratio [OR]=1.58, 95% confidence interval [CI]=1.16-2.15), a Clinical Global Impression score indicating greater severity (severe versus mild: OR=1.52, CI=1.08-2.15), and site (predicted probability range 8%-31%). Site was the most significant predictor of RCT enrollment (model excluding site, AUC=.61, CI=.58-.64; full model, AUC=.70, CI=.67-.73). CONCLUSIONS STEP-BD RCT participants differed from those in the observational arm in few clinical or demographic characteristics. Site was the strongest predictor of RCT participation. Future study is needed to understand site characteristics associated with RCT participation and whether these characteristics are associated with patient outcomes and to test these findings in usual-care settings.
A Dangerous Variant Causing Retropharyngeal Space Enlargement, Retropharyngeal Internal Carotid Artery: a case report

Aberrant internal carotid artery is a rare situation which may cause retropharyngeal space enlargement. We present an 88-year-old male patient with dysphagia and parapharyngeal mass related to this rare variant diagnosed by multi-slice computed tomography (CT) with clear multi-planar images and CT angiography.
Nicotinamide Cooperates with Retinoic Acid and 1,25-Dihydroxyvitamin D3 to Regulate Cell Differentiation and Cell Cycle Arrest of Human Myeloblastic Leukemia Cells

Nicotinamide, the amide derivative of vitamin B3, cooperates with retinoic acid (RA), a form of vitamin A, and 1,25-dihydroxyvitamin D3 (D3), to regulate cell differentiation and proliferation of human myeloblastic leukemia cells. In human myeloblastic leukemia cells, RA or D3 are known to cause MAPK signaling leading to myeloid or monocytic differentiation and G0 cell cycle arrest. In this process, RA or D3 induces the early expression of CD38, a receptor that causes ERK signaling and propels further differentiation. Our study demonstrates that nicotinamide in combination with RA or D3 affected induced expression levels of CD38, CD11b and CD14, suggesting a cooperative function of nicotinamide and RA or D3. Nicotinamide transiently retarded the initial RA- or D3-induced expression of CD38, which subsequently reached the same nearly 100% expression. Nicotinamide induced ERK activation and further enhanced the RA-induced ERK activation, but the D3-induced ERK activation was diminished by nicotinamide, although levels still exceeded those induced by RA, suggesting lineage-specific nicotinamide responses. Nicotinamide enhanced both RA- and D3-induced CD11b expression, inducible oxidative metabolism, and G0 cell cycle arrest, accelerating their induced occurrence in all instances. Consistent with this, the RA- or D3-induced downregulation of PARP was enhanced by nicotinamide. Nicotinamide thus regulated RA- or D3-induced differentiation and G0 arrest, causing a transient delay in certain early aspects of the progression to terminal differentiation but ultimately accelerating the occurrence of terminally, functionally differentiated G0 cells.
Avrupa Birliği Eğitim Programlarından Erasmus Programına Katılan Akademisyenlerin İzlenimleri

Bu calismanin amaci Cumhuriyet Universitesinde, Avrupa Birligi (AB) egitim programlarindan Erasmus’a katilan ogretim elemanlarinin izlenimlerini ortaya koymaktir. Bu calismayla ogretim elemanlarinin bu programlara katilma nedenleri, katilim surecinde yasadiklari sorunlar, kendi algilarina gore elde ettikleri kazanimlar ve ulkemiz ile ev sahibi ulkelerin egitim sistemleri arasindaki farkliliklar belirlenmeye calisilmistir. Calismada nitel arastirma yontemi kullanilmistir. Veriler, arastirmaci tarafindan hazirlanan gorusme formlari araciligiyla, 2006–2010 yillari arasinda Erasmus programina katilan 14 ogretim elemaniyla yari yapilandirilmis gorusmeler yoluyla ve Cumhuriyet Universitesi Dis Iliskiler biriminin sagladigi dokumanlarin analizinden elde edilmistir. Veriler icerik analizi teknigi ile analiz edilerek yorumlanmistir. Elde edilen bulgular; katilimcilarin Erasmus programinda yer alma nedenleri, bu surecte yasadiklari guclukler, kendi algilarina gore elde ettikleri kazanimlar ve bulunduklari ulke ile ulkemiz yuksekogrenim sistemi arasinda yaptiklari karsilastirmalar cercevesinde analiz edilerek, alt basliklar altinda sunulmustur. Calismanin bulgulari Erasmus programinin tum katilimcilar icin yararli oldugunu ve Avrupa Birligi egitim programlarinin amaclarina uygun olarak ileri duzeyde sonuclar elde edildigini ortaya koymustur. Anahtar Sozcukler: Akademik Hareketlilik, AB Egitim Programlari, Erasmus Programi ve Turkiye, Erasmus Programina iliskin Izlenimler This study aims at determining the implications of academic staff that joined the Erasmus program from Cumhuriyet University, in the frame of academic mobility. Several people and institutions in our country have benefited from the EU education programs since 2005. University students and academic staff have been important ones among them. Cumhuriyet University is also one of these universities whose staff and students have been increasingly attending those programs. Yet, the benefits and outcomes of joining these programs are not searched or evaluated in terms of academic concerns. So this study attempts to find out the reasons why academicians take place in these programs, the problems they encounter during the application and participation period, the benefits and outcomes according to their own perceptions and also the similarities and differences between our university and the visited one. Qualitative method was preferred for the study. Data were gathered from selected participant academicians who have joined any of Erasmus programs between the years 2006-2010. Semi-structured interview forms were prepared and used by the researcher. Also, data were supplied from CU International Office documents. Data were analyzed with content analysis techniques and evaluated. Results showed that all participants benefited from the program and they had a good experience. The results also show that the general objectives of those programs are realized in terms of several dimensions. Key Words: Academic mobility, EU education programs, Erasmus program and Turkey, Implications on Erasmus programs
A multicenter study on the audiometric findings of styrene-exposed workers

Abstract Objective: The objective of this study was to evaluate hearing loss among workers exposed to styrene, alone or with noise. Design: This cross-sectional study was conducted as part of NoiseChem, a European Commission 5th Framework Programme research project, by occupational health institutes in Finland, Sweden, and Poland. Study sample: Participants’ ages ranged from 18–72 years (n = 1620 workers). Participants exposed to styrene, alone or with noise, were from reinforced fiberglass products manufacturing plants (n = 862). Comparison groups were comprised of workers noise-exposed (n = 400) or controls (n = 358). Current styrene exposures ranged from 0 to 309 mg/m3, while mean current noise levels ranged from 70–84 dB(A). Hearing thresholds of styrene-exposed participants were compared with Annexes A and B from 2. Results: The audiometric thresholds of styrene exposed workers were significantly poorer than those in published standards. Age, gender, and styrene exposure met the significance level criterion in the multiple logistic regression for the binary outcome ‘hearing loss’ (P = 0.0000). Exposure to noise (<85 dBA p = 0.0001; ≥85 dB(A) p = 0.0192) interacted significantly with styrene exposure. Conclusions: Occupational exposure to styrene is a risk factor for hearing loss, and styrene-exposed workers should be included in hearing loss prevention programs. Sumario Objetivo: El objetivo de este estudio fue evaluar la pérdida auditiva en trabajadores expuestos a estireno, aisladamente o con ruido. Diseño: Se realizó este estudio transversal como parte del NoiseChem, Comisión Europea del 5°. Proyecto Marco de investigación, en institutos de salud ocupacional de Finlandia, Suecia y Polonia. Muestra de estudio: La edad de los participantes fue de 18–72 a os (N = 1,620 trabajadores). Los trabajadores (n = 862) estuvieron expuestos a estireno, solo o con ruido, en plantas de fabricación de productos de fibra de vidrio reforzada. Los grupos de comparación fueron trabajadores expuestos a ruido (n = 400) y los de un grupo control (n = 358). Las exposiciones reales a estireno variaron de 0 a 309 mg/m3, mientras que los niveles reales de ruido, variaron de 80–84 dB(A). Se compararon los niveles de audición de los participantes expuestos a estireno con los de los anexos A y B de 2. Resultados: Los umbrales audiométricos de los trabajadores expuestos a estireno, fueron significativamente más pobres que los que se han publicado como estándar. La edad, el género y la exposición a estireno, cubrieron los criterios de niveles de significatividad de la regresíón logística múltiple para los resultados binarios de la “perdida auditiva” (P = 0.0000). La exposición a ruido (<85 dB(A) p = 0.0001; ≥85 dB(A) p = 0.0192) interactu significativamente con la exposición a estireno. Conclusiones: La exposición ocupacional a estireno es un factor de riesgo de pérdida auditiva por lo que los trabajadores expuestos a estireno deben ser incluidos en programas de prevención de pérdidas auditivas.
An investigation on cephalometric parameters in Iranian population

Anthropometry is the biological science of human body measurement. Anthropometry is applied in medical profession such as maxillofacial surgery, growth and development studies, plastic surgery, bioengineering and non-medical branches such as like shoe-making and eye-glasses industries. The aim of this study was to determine Iranian cephalometric parameters and cranial and facial anthropometric ratios. This cross sectional analytical study was done randomly on 137 people from Nikshahr (Iran) with normal face patterns. Facial and cranial ratios was estimated and compared. Data was analyzed by SPSS software. The regression line and the growth coefficient were determined for each Parameter. Finally, the mean values of these parameters were determined. At birth, Iranian population have hypereuryprosopic face and hypercephalic cranium form. While getting older, the midface height increased, face became more prominent, chin became shorter and face and cranium changed to eurycephalic and hyperleptoprosopic forms, respectively. Due to the wide racial combinations in Iran, more studies, with wider sample size, should be conducted among different Iranian race. Key words: Anthropometry, craniofacial, Nikshahr.
Extracellular S100A9 Protein in Bone Marrow Supports Multiple Myeloma Survival by Stimulating Angiogenesis and Cytokine Secretion

In mouse multiple myeloma, treatment with the small molecule ABR-238901 interfered with calcium-binding protein S100A9, affected cytokine secretion and angiogenesis, and reduced tumor load. Results improved further when ABR-238901 was delivered in combination with the proteasome inhibitor bortezomib. Dysregulated expression of S100 protein family members is associated with cancer proliferation, invasion, angiogenesis, and inflammation. S100A9 induces myeloid-derived suppressor cell (MDSC) accumulation and activity. MDSCs, immunosuppressive cells that contribute to tumor immune escape, are the main producers of S100A9. In this study, we evaluated the role of extracellular S100A9 and the therapeutic relevance of S100A9 inhibition in multiple myeloma (MM), using the immunocompetent murine 5T33MM model. We demonstrated the presence of S100A9 and its receptor TLR4 in both monocytic and granulocytic MDSCs in human and mouse samples. We showed that S100A9 acted as a chemoattractant for MM cells and induced MDSCs to express and secrete inflammatory and pro-myeloma cytokines, including TNFα, IL6, and IL10. Blocking S100A9 interactions in vivo with the small molecule ABR-238901 did not directly affect MDSC accumulation but did reduce IL6 and IL10 cytokine expression by MDSC. ABR-238901 treatment in vivo reduced angiogenesis but had only minor effects on tumor load as single agent (6% reduction). However, ABR-238901 treatment in combination with bortezomib resulted in an increased reduction in tumor load compared with single treatments (50% relative reduction compared with bortezomib alone). Our data suggest that extracellular S100A9 promotes MM and that inhibition of S100A9 may have therapeutic benefit. Cancer Immunol Res; 5(10); 839–46. ©2017 AACR.