Miracle-dz/UniFAR-FTUs huggingface dataset:
Study of three patients with thrombotic thrombocytopenic purpura exchanged with solvent/detergent‐treated plasma: Is its decreased protein S activity clinically related to their development of deep venous thromboses?

Solvent/detergent treated plasma (S/DP) has reduced protein S activity (about 0.5 units/mL) as compared with fresh frozen plasma (FFP). When used as replacement fluid for repetitive therapeutic plasma exchange (PEX), e.g., in patients with thrombotic thrombocytopenic purpura (TTP), S/DP could lead to lowered protein S levels and, possibly, risk of hypercoagulable complications. We describe three patients with TTP who had low functional protein S (FPS) levels during PEX for TTP. Each developed one or more deep vein thromboses (DVTs) while receiving 100% S/DP or 50% S/DP and 50% cryosupernatant plasma (CSP) as replacement fluid. FPS levels rose when 100% CSP was substituted for S/DP. Our observations suggest that use of S/DP alone or in 50% combination with CSP as replacement fluid in PEX for TTP may lead to difficulty in maintaining safe FPS levels. Determination of risk of resulting clinically significant thrombotic events requires further study. J. Clin. Apheresis 15:169–172, 2000. © 2000 Wiley‐Liss, Inc.
OPEN LABEL TRIAL TO EVALUATE THE EFFICACY AND SAFETY OF YOKUKANSAN, A TRADITIONAL ASIAN MEDICINE, IN DEMENTIA WITH LEWY BODIES

cian’s choice to recommend surgery, taking into consideration the likelihood of perioperative mortality and postoperative complications, but advanced patient age alone should not prevent the surgeon from proceeding to surgery if clinically indicated. In particular, available data support pursuit of elective surgical procedures in nonagenarians and suggest that such procedures in this age group have an acceptable risk of morbidity and mortality. Laparoscopic approaches in nonemergent settings, in carefully selected nonagenarians, may reduce overall morbidity and shorten the recovery period.
PENGARUH FAKTOR-FAKTOR EKSTERNAL DAN INTERNAL TERHADAP KINERJA USAHA KECIL DAN MENENGAH DI JAKARTA

This study aims to analyse: (1) the effect of external factors on internal factors of SMEs; (2) the effect of external factors on SMEs performance; and (3) the effect of internal factors on SMEs performance in Jakarta. The result show that: (1) the external factors has positive and significant impact on internal factors of SMEs, (2) the external factors has positive but unsignificant on SMEs performance, and (3) the internal factors has positive and significant on SMEs performance in Jakarta. Keywords: Small and Medium Enterprises, External factors, Internal factors, SMEs performance
Language runtime support for NVM/DRAM hybrid main memory

Replacing of DRAM in main memory with non-volatile memory (NVM) has several merits. However, NVM under development has some limitations in write operation. To overcome it, some previous researches proposed NVM/DRAM hybrid memory architecture. In the architecture, it needs to determine data placements between NVM and DRAM. In this paper, we advocate that programming language runtimes are useful for management of NVM/DRAM hybrid main memory. In addition, we will propose a method to manage NVM/DRAM hybrid main memory with language runtime support.
Edaravone protects rats against oxidative stress and apoptosis in experimentally induced myocardial infarction: Biochemical and ultrastructural evidence

Objectives: The present study was designed to evaluate the cardioprotective potential of edaravone on oxidative stress, anti-apoptotic, anti-inflammatory and ultrastructure findings in isoproterenol (ISO) induced myocardial infarction (MI) in rats. Methods: Rats were pretreated with edaravone (1, 3, 10 mg/kg body weight-1 day-1) intraperitoneally. MI was induced by subcutaneous administration of ISO (85 mg/kg body weight-1) at two doses with 24h interval. Results: ISO treated rats showed significant increase in the levels of thiobarbituric acid reactive substances (TBARS) and decreased levels of reduced glutathione, glutathione perdoxidase, glutathione reductase and glutathione-S- transferase in the cardiac tissues. Moreover, significant increase in the levels of lactate dehydrogenase (LDH), creatine kinase-MB (CK-MB), C - reactive protein and caspase-3 activity was observed in ISO treated group. Pretreatment of ISO intoxicated rats with edaravone showed significant decrease in the level of TBARS, increased activities of antioxidant enzymes and significantly decreased levels of LDH and CK-MB. Moreover, results also showed decreased C-reactive protein level, caspase-3 activity and maintained ultrastructure of the myocardial cells. Discussion: Our study suggests that edaravone possess strong cardioprotective potential. Edaravone may have exhibited cardioprotective effects by restoring antioxidant defense mechanism, maintaining integrity of myocardial cell membrane, reducing apoptosis and inflammation against ISO induced MI and associated oxidative stress.
The effects of transport and lairage on counts of Escherichia coli O157 in the feces and on the hides of individual cattle.

OBJECTIVES The main objective of this study was to determine the impact of transport and lairage on the isolation rate and the number of Escherichia coli O157 on cattle. MATERIALS Ninety animals, divided into three groups (A, B, and C) of 30 animals each, were used in this study. Individual animals were tagged, and samples were collected from the hides and feces of each at a feedlot and again after slaughter. The carcass of each animal was also sampled. Samples were also collected from the feedlot pens, the sides and floors of the transport trucks, and abattoir holding pens. The isolation rate and the number of E. coli O157 were estimated using a combination of immunomagnetic separation and the Most Probable Number technique. RESULTS Cattle hides were more likely to be contaminated with E. coli O157 at the feedlot (31%) than at the abattoir (4%). E. coli O157 was detected in 18% and 12% of cattle feces collected at the feedlot and after slaughter, respectively. E. coli O157 was isolated from truck floors (26%), truck sides (11%), abattoir pen rails (47%), and pen floors (42%). The mean count of E. coli O157 in positive feces was log(10) 1.17 and 2.37 MPN/g at the feedlot and slaughter, respectively. A 3 log(10) increase in the number of E. coli O157 was observed between the feedlot (2.66 MPN/g) and slaughter (5.66 MPN/g) in the feces of one animal in group B. E. coli O157 was isolated from the hide and carcass of this animal. CONCLUSIONS Transport and lairage did not lead to an increase in the number or isolation rate of E. coli O157 from cattle. APPLICATIONS Intervention strategies for reducing E. coli O157 contamination of cattle carcasses should target mechanisms that limit the impact of animals shedding a high number throughout production and processing.
How Much Can Wi-Fi Offload? A Large-Scale Dense-Urban Indoor Deployment Study

This paper is envisaged to provide a first quantitative study on how much indoor deployed Wi-Fi can offload the operator's 3G HSPA macro cellular networks in a real large-scale dense-urban scenario. Wi-Fi has been perceived as a cost-effective mean of adding wireless capacity by leveraging low-cost access points and unlicensed spectrum. However, the quantitative offloading gain that Wi-Fi can achieve is still unknown. We studied the Wi-Fi offloading gain as a function of access point density, where it is shown that 10 access points/km2 can already boost average user throughput by 300% and the gain increases linearly proportional to the access point density. Indoor Wi-Fi deployment also significantly reduces the number of users in outage, especially for indoor area. A user is considered to be in outage if they have a user throughput less than 512 kbps. We also propose three Wi-Fi deployment algorithms: Traffic-centric, Outage-centric, Uniform Random. Simulation results show that Traffic-centric performs best in boosting average user throughput while Outage-centric performs best in reducing user outage. Finally, Wi-Fi offloading solution is compared with another offloading solution - HSPA Femto cell. We show that Wi-Fi provides both much higher average user throughput and network outage reduction than HSPA Femto cells by exploring 20 MHz unlicensed ISM band.
Point-of-care HbA 1 c tests-diagnosis of diabetes

Most cases (90%) of DM are type 2, which arises from defects in insulin action leading to insulin resistance, often combined with defects in insulin secretion. Circulatory insulin levels therefore may be normal or raised, but it cannot be used effectively. This subtype is predominant in middle-aged overweight patients with a sedentary lifestyle. In 2011 the WHO advocated the use of HbA1c for the diagnosis of type 2 DM and in 2012 UK guidance followed suit (2, 3).
Population‐based incidence and survival figures in essential thrombocythemia and agnogenic myeloid metaplasia: An Olmsted county study, 1976–1995

To provide basic information about occurrence and outcome of essential thrombocythemia (ET) and agnogenic myeloid metaplasia (AMM), we used the Rochester Epidemiology Project medical record linkage system for residents of Olmsted County, Minnesota. We identified all residents who were diagnosed with ET or AMM from 1976 to 1995. Community inpatient and outpatient medical records were reviewed to verify the diagnosis of ET or AMM, and patients were followed passively through their medical records to determine the outcome after diagnosis. We identified 39 cases of ET and 21 of AMM, with age‐ and sex‐adjusted incidence rates of 2.53 and 1.46 cases/100,000 population annually, respectively. The respective median ages at diagnosis were 72 and 67 years. The female‐to‐male ratios were 1.8 and 1.6 for ET and AMM, respectively, and when adjusted for age, there was no difference in risk. The median follow‐up period was 62.9 months for ET and 33.2 months for AMM. Five‐ and 10‐year survivals were 74.4% and 61.3%, respectively, for ET and were significantly lower than expected for age‐matched controls ( P = 0.012). Prognosis was worse for AMM, with a median progression time of 7 months and a 3‐year survival of 52.4%. This was significantly worse than for age‐matched controls (P < 0.001). This study provides population‐based incidence and comparative survival figures in ET and AMM. Am. J. Hematol. 61:10–15, 1999. © 1999 Wiley‐Liss, Inc.
Évolution cosmologique des propriétés physiques des galaxies

L'etude de la formation et de l'evolution des galaxies est une thematique en pleine effeversence. Deux grands releves (2dFGRS, SDSS), portant sur plusieurs millions de galaxies proches, ont permis recemment des avancees importantes dans la comprehension des proprietes physiques des galaxies. D'autre part l'arrivee des telescopes de 8-10m de diametre, equipes de spectroscopes multi-objets (VLT/VIMOS, Keick/DEIMOS, Gemini/GMOS, .), a permis la mise en place de plusieurs nouveaux grands releves portant cette fois sur les galaxies lointaines (VVDS, DEEP2, GDDS, zCOSMOS, .), donc situees dans un univers plus jeune. Ce travail de these porte preferentiellement sur l'etude des relations masse-metallicite ou luminosite-metallicite qui permettent d'etablir un lien entre les deux processus majeurs responsables de l'evolution des galaxies: l'assemblage de la masse stellaire (formation d'etoiles ou fusion de galaxies) et l'enrichissement chimique du milieu interstellaire par les generations d'etoiles successives. Nous montrons que la forme de cette relation est un tres bon test des modeles de formation et d'evolution des galaxies. Nous etudions ensuite la relation luminosite-metallicite de reference obtenue a partir du releve 2dFGRS dans l'Univers local. Puis nous etudions l'evolution en fonction de l'âge de l'univers de la relation luminosite-metallicite a l'aide d'un petit echantillon (LCL05), puis de la relation masse-metallicite a l'aide du grand releve VVDS. Plusieurs resultats obtenus avec ces differents echantillons sont des indices en faveur du modele hierarchique: les galaxies les plus massives se formeraient par fusion progressive de galaxies plus petites. Les proprietes physiques d'un grand nombre de galaxies sont estimees a l'aide d'outils d'analyse automatiques specifiquement developpes, ou adaptes a nos besoins, durant cette these. Comme resultats annexes, de nouvelles calibrations de la classification spectrale ou du taux de formation d'etoiles des galaxies sont obtenues a partir des grands releves de l'univers local (respectivement 2dFGRS et SDSS). Ce travail offre de nombreuses perspectives de par le nombre et la diversite des donnees disponibles.
[Effect of Twin-block appliance in the treatment of Class II and division I malocclusion: a cephalometric study in 12 patients].

PURPOSE To quantitatively evaluate the skeletal and dentoalveolar changes induced by Twin-block appliance for treatment of Class II,division I malocclusions in growing children. METHODS Twelve patients with Class II, division I malocclusions aged 10 to 12 years were investigated. The records were evaluated and compared with an age-matched sample of untreated Class II control subjects. The follow-up period was 12 months. Group t test was used for comparison. RESULTS In the treatment group, the upper incisors retroclination of the upper incisors and the mandibular forward movement contributed more to the overjet reduction. The skeletal and dental effects changes molar correction were almost similar. The mandibular growth in the treatment group was 2.29 mm, greater than that in the control group. The posterior facial height and the anterior lower facial height increased by 2.28 mm and 2.58 mm respectively. On the other hand, unfavorable vertical changes were not observed. CONCLUSIONS The treatment of Class II division I malocclusion with Twin-block appliance was effective in reducing overjet, correcting molar relationship and improving soft tissue profile. It can also enhance mandibular growth.
Maximum weight matching-based algorithms for k-edge-connectivity augmentation of a graph

The subject of the paper is to show that, by utilizing maximum-weight matching algorithms, we obtain heuristic algorithms of high capability for the k-edge-connectivity augmentation problem of graphs. The following points are shown by experimentally comparing the capabilities of eighteen algorithms for 4,175 graphs G' = (V, E') with 10/spl les/|V|/spl les/1400: (1) an existing algorithm, FSM, (previously proposed by us), based on an algorithm for finding a maximum-weight matching, produces the best solutions, while it becomes unrealistic when |V|>1000; (2) by utilizing a 2-approximation algorithm for the maximum-weight matching problem, a promising algorithm, HBD/sub a+/, is proposed, and it is shown that the second best solution (average 1.017 times that of FSM) is obtained in much shorter CPU time (average 0.1 times that of FSM).
Papanicolaou Smears Induce Partial Immunity Against Sexually Transmitted Viral Infections

Background: In a case-control study of hormonal contraceptives and invasive cervical cancer, an unexpected finding was a substantial decline in the prevalence of high-risk human papillomavirus (HPV) infection according to the lifetime number of Pap smears received. Here we assess the risk of 3 sexually transmitted viral infections—herpes simplex virus 2 (HSV2), HPV, and human immunodeficiency virus (HIV) 1 and 2—in relation to the lifetime receipt of Pap smears. Methods: Stored sera taken from 1540 controls were tested for HSV2 and HIV; cervical scrapings were tested for HPV. Confounder-adjusted odds ratios for the lifetime receipt of Pap smears were estimated, relative to never having had a Papanicolau test. Results: For ever-receipt of a Papanicolau test, the odds ratios for HSV2 and HPV were 0.7 (95% confidence interval = 0.5–0.9) and 0.5 (0.3–0.7), respectively, and there were dose-response trends according to the lifetime number of Pap smears received (test for trend P = 0.02 and 0.04, respectively). For HSV2 the odds ratios according to last receipt declined from 0.8 for 10 or more years previously to 0.4 for <1 year previously (trend P = 0.002). For HPV the ORs were 0.4 (0.3–0.7) for last receipt 5–9 years previously and 0.5 (0.4–0.8) for less than 5 years previously; for HIV the odds ratio for last receipt less than 5years previously was 0.4 (0.3–0.9). For HSV2 and HIV the crude odds ratio estimates were systematically lower than the adjusted estimates, and residual confounding cannot be ruled out. In particular, the true number of sexual partners may have been under-reported, and there was no information on the sexual activity of the male partners, or on other health behaviors of the women or their partners. Conclusion: We hypothesize that Pap smears may provoke a short-term immune response against sexually transmitted viral infections.
Treatment Methods in Tibial Condylar Fractures

Abstract: A series of 915 tibial condylar fractures has been analyzed for the type of treatment used and some of the pitfalls encountered with emphasis on preservation of fracture position. The most commonly used treatment methods are discussed in depth, emphasizing the advantages and disadvantages of each and their indications in the various types of tibial condylar fractures. It is concluded that the treatment must be carefully fitted to the type of fracture and to the patient in order to achieve a strong movable knee with good alignment and stability.
Diagnosis of impaired fetal growth in newborn infants.

Measurements of crown-heel length, head circumference, and birth weight were made on a large number of newborn infants. Birth weight by itself was frequently not a valid measure of fetal growth impairment. By including measurements of body length and head size along with birth weight, four distinct patterns of fetal growth impairment were identified. The four patterns included infants who had abnormally short body lengths for dates, infants who had evidence of disproportionate growth between body length and head circumference, infants who accumulated excessive amounts of soft-tissue mass, and infants who accumulated too little soft-tissue mass. Criteria for diagnosing each pattern were obtained prospectively and have been presented with allowances made for the effects of race, sex, fetal age, and parity on each pattern. The separate identification of the four patterns provided a more precise description of fetal growth impairment than could be obtained from birth weight and calculated gestational age.
The Effect of Mesencephalic Lesions on Tyramine and Dopamine in the Caudate Nucleus of the Rat

Abstract: The dopamine (DA)‐containing nerve terminals in the caudate nucleus arise from cell bodies located in the substantia nigra (pars compacta), and it is possible that p‐tyramine‐ and m‐tyramine‐containing neurons may also exist in this nucleus. We have studied the effects of unilateral electrolytic lesions of the pars compacta in rat on levels of DA, p‐tyramine, m‐tyramine, and homovanillic acid in the caudate nucleus after various survival times. At 12 and 24 h following lesioning the ipsilateral level of p‐tyramine was significantly reduced compared with the contralateral side, whereas the concentrations of m‐tyramine, DA, and homovanillic acid were significantly increased. Thus, in the short term, the lesion results in an increase in DA turnover, which is accompanied by an increase in m‐tyramine levels and a decrease in p‐tyramine levels. Similar changes occur following pharmacological treatments (chlorpromazine, d‐amphetamine, l‐DOPA) that increase DA turnover. At survival times of 2, 11, and 25 days, the ipsilateral concentrations of m‐tyramine, DA, and homovanillic acid were reduced along with p‐tyramine. These longer‐term alterations in amine levels are most likely a consequence of degeneration of nigro‐striatal axons. Placement of a lesion 1 mm dorsal to the usual position centering on the pars compacta produced different biochemical changes from those seen after the pars compacta lesion. One day following this lesion the concentration of p‐tyramine was slightly reduced; DA was unaffected, but the concentration of m‐tyramine was profoundly increased, even more so than after the pars compacta lesion. This could indicate the existence of specific m‐tyramine‐containing cell bodies located dorsal to the substantia nigra. The results suggest that p‐ and m‐tyramine in the caudate nucleus originate from neurons in or close to the substantia nigra. The results in the short term following the lesion support the observation that there is an inverse relationship between p‐tyramine concentration and DA turnover in the caudate nucleus.
Internalization of blocking antibodies against mannose‐6‐phosphate specific receptors.

Antibodies against mannose‐6‐phosphate specific receptors inhibit the receptor‐dependent endocytosis of exogenous lysosomal enzymes as well as the sorting of endogenous lysosomal enzymes. This inhibition was correlated with an apparent loss of the receptors. We report here that treatment of cells with the antibody results in the formation of receptor‐antibody complexes that are not extracted by the procedure used for the solubilization of receptors prior to immunoprecipitation and detection of the receptor. The apparent loss of receptors is observed with both native antibody and the F(ab)2 fragments, but not with Fab fragments. In contrast the transport of lysosomal enzymes is inhibited by all three forms of the antibody. The inhibition is ascribed to masking by the antibody of the enzyme‐binding site in the receptor. The inhibition of the sorting of endogenous lysosomal enzymes by antibodies added to the medium indicates that the mannose‐6‐phosphate specific receptors at the sorting site are in dynamic equilibrium with those at the cell surface. The receptor‐antibody complexes formed at the cell surface appear to cycle between the cell surface and intracellular membranes. A fraction of the internalized antibodies dissociates from the receptors and is degraded after transfer into lysosomes. Complexing with Fab increases the concentration of the receptor in the lysosomes and decreases 2‐ to 3‐fold the half‐life of the receptor.
Diabetes Prevalence and Care in the Métis Population of Ontario, Canada

OBJECTIVE The Métis are a distinct Aboriginal people in Canada with a unique history, culture, and language. This study examined diabetes prevalence and care in the Métis of Ontario. RESEARCH DESIGN AND METHODS The 14,480 people in the citizenship registry of the Métis Nation of Ontario were linked with provincial health care databases to determine diabetes prevalence and processes of care. Rates were compared between the Métis and the general Ontario population. RESULTS The age/sex standardized prevalence of diabetes for the Métis was 11.2%, nearly 25% higher than that of the general Ontario population. Métis were more likely to be hospitalized (12.7 vs. 10.7%) or require emergency room visits (36.1 vs. 27.7%). CONCLUSIONS Métis people have an increased burden of diabetes that puts them at risk for complications and morbidity. Ensuring adequate access to and quality of care for diabetes is essential to maintain the health of the Métis people.