Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparison of ovarian response between PCOS and Non-PCOS patients undergoing ICSI with antagonist protocol

Antagonists have been shown to be better than agonists in general and in the PCOS infertility with lower rate of OHSS. This study is a retrospective observational study and patient record review of PCOS and Non-PCOS groups of patients who entered ART over a duration of 3 years. On comparison of ovarian response in both groups, the mean number of oocytes obtained was more in the PCOS group but the number of mature oocytes obtained was significantly less. A higher fertilization rate and cleavage rate was observed in the nonPCOS patients i.e. 82.3% and 73.2% respectively versus 71% and 58.7% in the PCOS group which was statistically significant. There were no patients with OHSS in the nonPCOS group, whereas in the PCOS group we had 10 patients with mild OHSS, 4 (6%) patients with moderate OHSS and only 1 (1%) patient with severe OHSS. In conclusion the pregnancy rate was comparable in patients with PCOS undergoing GnRH antagonist ovarian stimulation compared with non-PCOS patients in whom the same controlled ovarian stimulation was used. Of importance is the fact that there was only one case of severe ovarian hyperstimulation syndrome in the PCOS group, making the use of the GnRH antagonist an attractive option in this high-risk group of patients.
PSMA-Based Radioligand Therapy for Metastatic Castration-Resistant Prostate Cancer: The Bad Berka Experience Since 2013

A potential milestone in personalized nuclear medicine is theranostics of metastatic castration-resistant prostate cancer (mCRPC) based on molecular imaging using PET/CT with 68Ga-labeled prostate-specific membrane antigen (PSMA) ligands and molecular radiotherapy using PSMA-targeted radioligand therapy (PRLT) with 177Lu-PSMA ligands. 68Ga-PSMA PET/CT enables accurate detection of mCRPC lesions with high diagnostic sensitivity and specificity and provides quantitative and reproducible data that can be used to select patients for PRLT and therapeutic monitoring. Our comprehensive experience over the last 3 years using different radioligands indicates that PRLT is highly effective for the treatment of mCRPC, even in advanced cases, and potentially lends a significant benefit to overall and progression-free survival. Additionally, significant improvement in clinical symptoms and excellent palliation of pain can be achieved.
MARKET TIMING : SIN A LITTLE RESOLVING THE VALUATION TIMING PUZZLE

Successful market timing is a tantalizing holy grail for investors, especially when there seems to be persuasive evidence that simple valuation measures can predict subsequent market performance. But, as both researchers and investors have discovered, outperforming a passive buy-and-hold approach is harder than it might seem. Is market timing a useful source of added value or a sin to be avoided? In this paper we explore the difference between the encouraging in-sample long-horizon evidence and directionally right but weak and disappointing out-of-sample performance. We propose an interpretation that offers a practical enhancement to value timing strategies: adding a dose of momentum.
Pharmacodynamics of doxorubicin in human prostate tumors.

The pharmacodynamics of doxorubicin in human prostate tumors were studied using histocultures of radical prostatectomy specimens. Drug treatment lasted 96 h. The antiproliferative effect was measured by the inhibition of DNA precursor ([3H]thymidine) incorporation, and the cytotoxic effect was measured by monitoring cells with fragmented DNA, as indicated by the terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling assay. The average [3H]thymidine labeling index in 17 tumors was 39% (range, 20-56%). The antiproliferative and cytotoxic effects were concentration dependent and reached 100% at 6 and 17 microM doxorubicin. The cytotoxic concentrations were significantly higher than the antiproliferative concentrations, indicating that prostate tumors were more sensitive to the antiproliferative effect than they were to the cytotoxic effect of doxorubicin. The antiproliferative effect was inversely correlated with patient's age (P < 0.02) and weakly correlated with LI and Gleason grade (P = 0.07 and 0.06, respectively), but it was not correlated with clinical stage, prostate-specific antigen secretion, or race of patients (P > 0.12). In contrast, the cytotoxic effect was positively correlated with Gleason grade (P < 0.05) and weakly correlated with stage (P < 0.08), but it was not correlated with the other parameters (P > 0.18). The opposite correlations between the two effects with tumor grade suggest that the two effects are not coupled. A comparison of the drug concentrations required to produce 50% antiproliferative (0.06 microM) and cytotoxic (2 microM) effects and the literature data on plasma drug concentrations derived from systemic treatment suggest that there are minimal drug effects at the clinically achievable drug concentrations and that regional delivery of doxorubicin to the prostate may be necessary to provide adequate concentrations to produce antiproliferative and cytotoxic effects.
A Tunable 5–7 GHz Distributed Active Quasi-Circulator With 18-dBm Output Power in CMOS SOI

Circulators and quasi-circulators (QCs) have a tradeoff between maximum isolation and bandwidth. We present a tunable distributed active circuit to achieve high isolation over a wide frequency range. The reported QC provides more than 40-dB suppression between transmit (TX) output signal at the antenna and TX leakage into the receive (RX) port over a tuning range of 5.3–7.3 GHz in small-signal operation. Large-signal TX-RX suppression is optimized across power level. The TX output achieves peak power of 18 dBm and 12% power-added efficiency at 6.3 GHz. The QC is designed in a high-resistivity 45-nm CMOS silicon-on-insulator process and occupies an area of <inline-formula> <tex-math notation="LaTeX">$1.62~ \text {mm} \times 0.97~ \text {mm}$ </tex-math></inline-formula>.
Matrix Operations Using Arrays with Reconfigurable Optical Buses*

This paper examines the possibility of implementing matrix operations on an array with reconfigurable optical buses (AROB). The AROB combines some of the advantages and characteristics of reconfigurable meshes and meshes with optical pipelined buses. This model is extremely flexible, as demonstrated by its ability to efficiently simulate CREW PRAMs and reconfigurable networks. A number of applications arc investigated and it is shown that many matrix operations can be implemented efficiently, reducing the time complexity and/or the cost of existing algorithms which are given for other models of parallel computation.
[Acupoint sticking therapy for treatment of bronchial asthma: a multicenter controlled randomized clinical trial].

OBJECTIVE To observe the effect of acupoint sticking on clinical symptoms and life quality in patients with bronchial asthma. METHODS Multicenter randomized double-blind clinical trial was done, one hundred and eighty-eight cases were divided into a medication acupoint sticking group (125 cases) and a placebo group (63 cases). Dazhui (GV 14), Feishu (BL 13), Tiantu (CV 22), etc. were selected in both groups. The medication cakes were made of grinding pepper, brassica alba seeds, asarum, etc. into fine powder mixed with ginger oil and ginger juice, applied on acupoints in the acupoint sticking group. While another compound cakes made of powder of red rice, black rice, maize mixed with small amount of ginger juice, were used in the placebo group. Asthma Quality of Life Questionnaire(AQLQ), symptom scores during the day and night, scores of self effect, and the value of lung function were observed. RESULTS The value of daily behavior and environmental factors of AQLQ, total scores of AQLQ, daytime symptoms and scores of self effect in the medication acupoint sticking group, were significantly improved compared to those of placebo group (all P<0.05). The lung function of forced expiratory volume in one second (FEV1) and the percentage of forced expiratory volume in one second in predicted value (FEV1/FVC) had no significant diffrence between two groups (both P>0.05). CONCLUSION The acupoint sticking therapy can significantly improve clinical symptoms of patients with bronchial asthma, and can improve life quality of the patients.
Telomeric lengths and telomerase activity in liposarcomas

To assess the role of telomerase in the development of liposarcomas, we measured telomerase activity in 36 malignant and seven benign lipomatous neoplasias from 34 patients. A sensitive polymerase chain reaction–based telomerase assay (the telomeric repeat amplification protocol) was applied. Shortening or elongation of telomeric repeat fragment lengths, as measured by using hybridization with a telomere‐specific oligonucleotide probe, was correlated with the presence of telomerase activity. The latter was demonstrable in 69% of malignant tumors. Benign tumors can be distinguished from malignant neoplasias on the basis of telomerase activity. However, telomerase expression seems to be characteristic of poorly differentiated liposarcomas. Myxoid/round cell liposarcomas exhibited a higher telomerase activity level than the classical low‐grade variants. Telomerase activity was not correlated with age at the time of diagnosis or with sex. In most cases, telomerase‐positive tumors showed higher proliferation indices than did neoplasias lacking telomerase. All eight recurrences expressed telomerase activity, reflecting a close association of telomerase with the biological behavior of liposarcomas. Our findings suggest that telomerase may play a key role in the establishment and progression of malignant lipomatous tumors. Mol. Carcinog. 24:144–151, 1999. © 1999 Wiley‐Liss, Inc.
Factors Affecting the Adoption of Information and Communication Technologies: Small Hotels and Tour Operators in Addis Ababa, Ethiopia

Abstract In Africa the adoption of Information and Communication Technologies (ICTs) varies considerably from one country to another, for example between Kenya and Tanzania on the one hand and Ethiopia on the other. In Kenya and Tanzania telecommunications systems have been liberalized, while in Ethiopia all ICT infrastructures and services are provided by one single telecommunications operator – one that is owned and run by the government. ICT plays a significant role in poverty reduction and empowerment of the disadvantaged, but this requires that ICT has first to be adopted by them. The main research question is: what are the factors affecting the adoption of ICT in the small hotel and tour operator sector? The purpose of this paper is to examine the factors that affect the adoption of ICT in small hotels and tour operators in Ethiopia’s capital city, Addis Ababa. The sector was chosen because, driven by demand from customers, it uses ICT more than many other sectors, and because the government requires hoteliers to use a particular software for tax purposes. During the course of several visits between 2009 and 2013 data were collected from hoteliers and tour operator owners/managers. Sixteen hoteliers who had adopted ICT in their businesses were interviewed. One hundred and twenty-eight hoteliers and 57 tour operators responded to a questionnaire. Analysis of the findings indicates that factors affecting the adoption of ICT in these organizations can be arranged according to three levels: individual, organizational and national. The major factors that affect the adoption arise from the national level factors: the political, socio-economic, technological and legal factors that play a critical role in the adoption or rejection of ICT in this sector. This paper provides insights into the impact a monopolized telecommunications service can have on the adoption of ICT.
The natural history of cytogenetically abnormal fetuses detected at midtrimester amniocentesis which are not terminated electively: new data and estimates of the excess and relative risk of late fetal death associated with 47,+21 and some other abnormal karyotypes.

We report the results of an ongoing survey of rates of spontaneous death of fetuses with chromosome abnormalities detected at second-trimester amniocentesis in which the mother did not elect abortion. Estimated excess risks (and conservative 90% confidence intervals) of spontaneous fetal death for various cytogenetic abnormalities are as follows: 47,+21, 25.6% (18.0%-34.0%); 47,+18, 63.8% (49.3%-79.8%); 47,+13, 36.5% (11%-69.7%); 45,X, 65.3% (41.0%-84.2%); and mosaic 45,X/46,XX, 10.8% (1.0%-26.8%). There is little evidence for an excess risk of fetal death, at least following amniocentesis, for 47,XXX, 47,XXY, or 47,XYY. The excess risks of fetal death were adjusted for the likelihood that a fetus of normal karyotype would undergo spontaneous fetal death in a population of older maternal age similar to that in which prenatal cytogenetic diagnosis is undertaken. The absolute fetal death rates when this factor is ignored are about 3.5% higher (i.e., may be derived by adding 3.5% to the values given). The excess risks are those which are most appropriate for use in estimating the contribution of chromosome abnormalities to spontaneous fetal death.
Neurofibrillary tangle formation in the nucleus basalis of meynert ipsilateral to a massive cerebral infarct

Two cases of massive cerebral infarct in the territory of the middle cerebral artery on one side of the brain are presented, in which many (Patient 1) or several (Patient 2) neurofibrillary tangle‐bearing neurons were observed in the nucleus basalis of Meynert (nbM), ipsilateral to the infarcts. Tangles were absent or rare in the opposite nbM or in other areas of the brain. Considering the widespread projection of nbM axons to the ipsilateral cerebral cortex, this suggests that formation of neurofibrillary tangles can occur as a retrograde reaction of nbM neurons secondary to massive, old cerebral infarction.
Proposed methodology for earthquake-induced loss assessment of instrumented steel frame buildings: building-specific and city-scale approaches

The performance-based earthquake engineering framework utilizes probabilistic seismic demand models to obtain accurate estimates of building engineering demand parameters. These parameters are utilized to estimate earthquake-induced losses in terms of probabilistic repair costs, life-safety impact, and loss of function due to damage to a wide variety of building structural and non-structural components and content. Although nonlinear response history analysis is a reliable tool to develop probabilistic seismic demand models, it typically requires a considerable time investment in developing detailed building numerical model representations. In that respect, the challenge of city-scale damage assessment still remains. This paper proposes a simplified methodology that rapidly assesses the story-based engineering demand parameters (e.g., peak story drift ratios, residual story drift ratios, peak absolute floor accelerations) along the height of a steel frame building in the aftermath of an earthquake. The proposed methodology can be employed at a city-scale in order to facilitate rapid earthquake-induced loss assessment of steel frame buildings in terms of structural damage and monetary losses within a region. Therefore, buildings within an urban area that are potentially damaged after an earthquake event or scenario can be easily identified without a detailed engineering inspection. To illustrate the methodology for rapid earthquake-induced loss assessment at the city-scale we employ data from instrumented steel frame buildings in urban California that experienced the 1994 Northridge earthquake. Maps that highlight the expected structural and nonstructural damage as well as the expected earthquake-induced monetary losses are developed. The maps are developed with the geographical information system for steel frame buildings located in Los Angeles.
Progressive reduction in treatment‐related deaths in Medical Research Council childhood lymphoblastic leukaemia trials from 1980 to 1997 (UKALL VIII, X and XI)

In the last 20 years, the survival rate for children with acute lymphoblastic leukaemia (ALL) has markedly improved, largely owing to a decrease in relapses. However, children still die from complications of treatment and these are potentially preventable. We have analysed data from three large consecutive national protocols for ALL from 1980 to 1997 [Medical Research Council United Kingdom ALL (MRC UKALL) trials VIII, X and XI] to compare the incidence and causes of treatment‐related deaths (TRD). The percentage of TRD has fallen from 9% to 2% (UKALL VIII to XI), largely as a result of a decrease in fatal infections. Deaths during induction have fallen from 3% to 1%, the main causes of death being bacterial, followed by fungal infection, while other causes, chiefly haemorrhage, have not declined. Remission deaths also decreased from 6% to 1%, particularly those deaths due to measles and pneumocystis carinii. More guidelines for surveillance and treatment of infections have been included within progressively more intensive protocols. Risk factor analysis showed increased TRD in patients with Down's syndrome, high leucocyte count and older age in UKALL XI. In contrast, the introduction of blocks of intensification was not associated with an increased death rate. While improved supportive care has reduced the incidence of TRD, there is still scope for further reduction by prompt treatment of suspected infection. Maintenance of herd immunity remains of vital importance in avoiding deaths from measles.
Prospective randomized study of carotid endarterectomy with polytetrafluoroethylene versus collagen-impregnated Dacron (Hemashield) patching: perioperative (30-day) results.

PURPOSE Several studies have reported that carotid endarterectomy (CEA) with patch angioplasty has results that are superior to primary closure. Polytetrafluoroethylene (PTFE) patching has been shown to have results comparable with autogenous vein patching; however, it requires a prolonged hemostasis time. Therefore, many surgeons are using collagen-impregnated Dacron patching (Hemashield [HP]). This study is the first prospective randomized trial comparing CEA with PTFE patching versus HP patching. METHODS Two hundred CEAs were randomized into two groups, 100 PTFE and 100 HP patching. All patients underwent immediate postoperative and 1-month postoperative color duplex ultrasound scanning studies. Demographic and clinical characteristics were similar in both groups, including the mean operative diameter of the internal carotid artery. RESULTS The perioperative stroke rates were 0% for PTFE, versus 7% for HP (4 major and 3 minor strokes, P =.02). The combined perioperative stroke and transient ischemic attack rates were 3% for PTFE, versus 12% for HP (P =.047). The operative mortality rate for PTFE was 0%, versus 2% for HP (P =.477). Five perioperative carotid thromboses were noted in patients undergoing HP patching, versus none in patients undergoing PTFE patching (P =.07). After 1 month of follow-up, 2% of patients in the PTFE group had a 50% or more restenosis, versus 12% of patients in the HP group (P =.013). The mean operative time for PTFE patching was 119 minutes, versus 113 minutes for HP patching (P =.081). The mean hemostasis time was significantly higher for PTFE patching than for HP patching, 14.4 versus 3.4 minutes (P <.001). CONCLUSION CEA with HP patching had a higher incidence of perioperative strokes, carotid thrombosis, and 50% or more early restenosis than CEA with PTFE patching. However, the mean hemostasis time was higher for PTFE patching than for HP patching.
Wavelet noise

Noise functions are an essential building block for writing procedural shaders in 3D computer graphics. The original noise function introduced by Ken Perlin is still the most popular because it is simple and fast, and many spectacular images have been made with it. Nevertheless, it is prone to problems with aliasing and detail loss. In this paper we analyze these problems and show that they are particularly severe when 3D noise is used to texture a 2D surface. We use the theory of wavelets to create a new class of simple and fast noise functions that avoid these problems.
Formation of UV‐induced apoptosis relates to the cell cycle

The relationship of the rate of epidermal proliferation to ultraviolet (UV)‐induced cell death, namely sunburn cell (SC) formation, was investigated in vivo using the guinea‐pig model. The number of SCs was correlated with (1) cellophane tape stripping which stimulates the proliferation rate and (2) treatment with antimitotic and antimetabolic agents which suppress the proliferation rate. The tape stripping performed 14 h before UV irradiation significantly increased the number of SCs counted 24 h after UV irradiation from a mean of 17.4 to 62.6 per section, and the tritiated thymidine (TdR‐3H)‐labelling index (LI) increased from a mean of 8.1 to 27.4%. SC counts and LI were markedly decreased by the intradermal injection of colchicine, methotrexate, hydroxyurea or 5‐fluorouracil given once immediately after the tape stripping. The autoradiographic study showed that 23.2% of SCs were labelled when TdR‐3H was given intradermally 1 h before UV exposure, while no SCs were labelled when TdR‐3H was given immediately after UV exposure. The labelled SC count (23.2%) which presumably represents S phase cells at the time of UV exposure, was higher than the LI (mean 8.1%). These results suggest that proliferating cells, possibly S phase cells, may be responsible for SC formation.