Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessment of explosive strength-endurance in volleyball players through vertical jumping test

Rev Bras Med Esporte _ Vol. 13, No 3 – Mai /Jun, 2007 1. Faculdade de Educação Física – PUC-Campinas – Campinas, São Paulo (SP), Brasil. 2. Faculdade de Educação Física – UNICAMP – Campinas, São Paulo (SP), Brasil. Approved in 29/11/06. Correspondence to: Jefferson Eduardo Hespanhol, Rua Buarque de Macedo, 101, apto. 14, bloco-3, Guanabara – 13073-010 – Campinas, SP, Brazil. Tel. : (19) 3212-0408. E-mail: Jeffehespa@hotmail.com Assessment of explosive strength-endurance in volleyball players through vertical jumping test
Is serum transferrin receptor useful for detecting iron-deficiency in anaemic patients with chronic inflammatory diseases?

We investigated whether determination of serum transferrin receptor (TfR) is useful for detecting iron-deficiency in patients with chronic inflammatory diseases and for differentiating between iron-deficiency anaemia and anaemia of inflammation. Using an immunofluorometric assay, serum TfR was measured in 34 anaemic patients. Of these patients, 23 had a chronic rheumatic disease, 13 with both inflammation and iron-deficiency and 10 with anaemia of inflammation only; the other 11 patients had iron-deficiency anaemia and no evidence of inflammation. Serum TfR concentrations were lower in patients with anaemia of inflammation (2.6 +/- 0.2 mg/l, mean +/- S.E.M.) than in patients with iron-deficiency anaemia (6.7 +/- 1.1 mg/l, P < 0.01) or those with both inflammation and iron deficiency (5.8 +/- 1.0 mg/l, P < 0.01). Among patients with inflammatory disease, correlations between TfR and ferritin concentrations (r = -0.62, P < 0.05) and TfR and erythropoietin concentrations (r = 0.69, P < 0.001) were observed in iron-deficient subjects only. TfR, though not superior to serum ferritin, can help to distinguish between anaemia of inflammation and iron-deficiency anaemia and to identify iron-deficiency in subjects with chronic inflammation.
An upstream repressor element plays a role in Igf2 imprinting

The imprinted Igf2 gene is associated with a small upstream region that is differentially methylated on the active paternal allele. We have identified a repressor element within this sequence and shown that repression is probably mediated through a trans‐ acting factor, GCF2. DNA methylation of this site abrogates both protein binding and repressor activity. Targeting experiments demonstrate that this element plays a role in the repression of the maternal Igf2 gene in vivo.
DNA: Web-based content posting interaction in pervasive display

In the case of natural disaster, there is a need for an integrated information presentation system. The increasing number of public display could be used as a medium for that system. But currently, public display is developed as a closed system. Where only display owner could post content on it. It needs to move to a more open system that allows people contribution beyond display owner. In this paper, we proposed an interaction flow that could foster posting content activity in a system called DNA (Digital Notice Area). We tried to be similar to posting content activity in the traditional “Public Notice Areas”. From our preliminary research, we found that our proposed interaction has a SUS score of 69.25. Which means that it is acceptable but still need improvement.
Mathematical Analysis of Glioblastoma Invasion Models from in Vitro Experiment

Stein et al. proposed a continuum mathematical model describing Glioblastoma invasion ob-served in their experiments on the patterns of growth and dispersion of U87MG tumour spheroids in a three-dimensional collagen-I gel. They identify and characterise discrete cellular mechanisms underlying invasive cell motility from the experimental data. However in their experiments it is observed micro-scopically that the U87MG invasive cells often exhibit more complicated and irregular behaviour than expressed by their model. We propose a mathematical model by generalising the radially biased motility term in their model based on the mechanism govering the behaviour of U87MG cell in the experiment. We show a rigorous mathematical analysis of our model and give computer simulations of the experiment based on our mathematical model.
Pioneer colonizer microorganisms in biofilm formation on galvanized steel in a simulated recirculating cooling‐water system

Some bacteria have a higher tendency to produce biofilm than others. Especially, Pseudomonas and Aeromonas strains are acknowledged to be pioneer colonizers and are predominant in biofilm formation. We examined biofilm formation and first attachment maintance of biofilms of Pseudomonas spp. , Pseudomonas aeruginosa, Aeromonas spp, sulphate reducing bacteria and filamentous fungi. A simulated recirculating cooling‐water system was used. Heterotrophic bacteria counts on galvanized steel and glass surfaces rose during the tidy period of 720 hours. In addition, we determined that although Pseudomonas spp. , Pseudomonas aeruginosa and Aeromonas spp. were the pioneer colonizers, they surprisingly could not be determined in the biofilms on both types of surface after 456 hours. Sulphate reducing bacteria were observed in biofilms on both surfaces from the outset of the experiments. Filamentous fungi were seen on the galvanized steel and glass surfaces after 0.5 h. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Intracapsular Organization of Ciliary Zonules in Monkey Eyes

Ciliary zonules are responsible for changing the curvature of a lens in the dioptric focus of an eye. Present established theory is based on the relaxation of zonular superficial fasciculi affixed to the capsular surface, thereby inducing the change of anterior‐ and posterior lens curvature causing spontaneous liquid movement of lens material. To achieve precise focusing at any distance, a more active functional organization should exist. The present studies were performed to determine not only the surface attachment but also the intracapsular affix of zonules on monkey eyes. In addition, the development of focusing in newborn and presbyopia is analyzed. Histology was prepared by conventional and molecular immunofluorescence stainings on the compositions of zonules with fibrillin‐1 (FBN 1) and lens capsule with collagen IV (COL IV), and in situ hybridization (ISH) analyses on frozen sections. Superficial circumferential attachments of zonule were found radially oriented between ciliary processes and anterior/posterior lens capsules forming a triangular figure. Two functional intralayer integrations were found above them; anterior‐posterior crossed fibers over the equator and radial fibers distributed toward the anterior or posterior polar areas. These fibers were bound tightly to the deep layer connective tissues close to the lens epithelium. Fine zonular fibers were aggregated, gradually forming bundles and bifurcated again on the way to the capsule. The lateral striped staining pattern in bundles suggested their elastic nature. Response of α‐helixes of collagen IV immunostaining was more positive on α‐1,2,4 than α‐3,5,6 on anterior‐ and posterior lens capsules. Newborn eyes revealed not fascicular but fine membranous zonules on the lens surface and small ciliary processes. ISH analysis revealed high synthetic expression of FBN 1 mRNA in cytoplasm of nonpigmented epithelial cells of ciliary processes. The synthetic expression of FBN 1 declined with aging. According to the mechanism of accommodation, active dynamic movement of anterior or posterior capsules play the main role of changing the lens configuration by two intralayer zonular integrations, including anterior‐posterior crossed fibers over the equator and radial fibers toward anterior or posterior polar areas acting with coordinated contraction of circular or longitudinal ciliary muscles. The developmental change on focusing is brought about by synthesis of FBN 1 in the newborn eye. Anat Rec 293:1797–1804, 2010. © 2010 Wiley‐Liss, Inc.
Listening and Learning: Cognitive Contributions to the Rehabilitation of Older Adults With and Without Audiometrically Defined Hearing Loss

Here, we describe some of the ways in which aging negatively affects the way sensory input is transduced and processed within the aging brain and how cognitive work is involved when listening to a less-than-perfect signal. We also describe how audiologic rehabilitation, including hearing aid amplification and listening training, is used to reduce the amount of cognitive resources required for effective auditory communication and conclude with an example of how listening effort is being studied in research laboratories for the purpose(s) of informing clinical practice.
Some glial progenitors in the neonatal subventricular zone migrate through the corpus callosum to the contralateral cerebral hemisphere

The great majority of glial cells of the mammalian forebrain are generated in the perinatal period from progenitors in the subventricular zone (SVZ). We investigated the migration of progenitors from the neonatal (postnatal day 0, P0) rat forebrain SVZ by labeling them in vivo with a green fluorescence protein (GFP) retrovirus and monitoring their movements by time‐lapse video microscopy in P3 slices. We identified a small number of progenitors that migrated tangentially within the corpus callosum (CC) and crossed the midline. These cells retained a relatively uniform morphology: the leading process was extended toward the contralateral side but showed no process branching or turning away from the migratory direction. Net migration requires the elongation of the leading process and nuclear translocation, and the migrating cells in the CC showed both modes. We confirmed the presence of unmyelinated axon bundles within the P3 CC, but failed to detect any radially directed glial processes (vimentin‐ or GLAST‐immunolabeled fibers) spanning through the CC. Confocal images showed a close proximity between neurofilament‐immunolabeled axons and the leading process of the GFP‐expressing progenitors in the CC. The destination of the callosal fibers was examined by applying DiI to the right cingulum; the labeled fibers ran throughout the CC and reached the left cingulate and motor areas. The distribution and final fates of the retrovirus‐labeled cells were examined in P28 brains. A small proportion of the labeled cells were found in the contralateral hemisphere, where, as oligodendrocytes and astrocytes, they colonized predominantly the cortex and the underlying white matter of the cingulate and secondary motor areas. The distribution pattern appears to coincide well with the projection direction of the callosal fibers. Thus, glial progenitors migrate across the CC, presumably in conjunction with unmyelinated axons, to colonize the contralateral hemisphere. J. Comp. Neurol. 458:381–388, 2003. © 2003 Wiley‐Liss, Inc.
Beyond the numbers: Mining the Annual Reports for Hidden cues Indicative of Financial Statement Fraud

Unlike previous fraud detection research, a vast majority of which has focused primarily on the use of quantitative financial information to predict fraud, in this study we examine qualitative textual content in annual reports to predict fraud and see whether there are discernible differences in the writing and presentation style between companies that committed fraud and those that did not. We believe that while numeric financial information in the annual reports can hide details of fraud, textual information relating to writing and presentation styles in such reports provides valuable clues pertaining to the existence of fraud. In this study we use the chi-square test to analyse our data and test hypotheses about predictors of fraud that may explain linguistic feature variations in fraudulent and nonfraudulent annual reports. We provide new results on the usefulness of the qualitative content of annual reports in detecting fraud. Copyright © 2012 John Wiley & Sons, Ltd.
Birth cohort analysis of changing suicide risk by sex and age in Sweden 1952 to 1981

ABSTRACT: The study aims at exploring the sex and age shift in suicide in Sweden. Data from the Causes of Death Register comprising suicides occurring in 1952 to 1981 among persons born in 1877 to 1966 were included. Analysis of linear regression of cumulative suicide incidence in successive birth cohorts yielded a shift toward younger ages and a general increase in female suicide risk. The statistical suicide risk in the 20 to 24 male age group has increased 3.6 times. The male to female suicide risk sex ratio has decreased for those older than 45, while it has increased among young adults. There is an urgent need of explanatory studies.
CERT Mediates Intermembrane Transfer of Various Molecular Species of Ceramides*

Ceramide produced at the endoplasmic reticulum is transported to the Golgi apparatus for conversion to sphingomyelin. The main pathway of endoplasmic reticulum-to-Golgi transport of ceramide is mediated by CERT, a cytosolic 68-kDa protein, in a nonvesicular manner. CERT contains a domain that catalyzes the intermembrane transfer of natural C16-ceramide. In this study, we examined the ligand specificity of CERT in detail by using a cell-free assay system for intermembrane transfer of lipids. CERT did not mediate the transfer of sphingosine or sphingomyelin at all. The activity of CERT to transfer saturated and unsaturated diacylglycerols, which structurally resemble ceramide, was 5–10% of the activity toward C16-ceramide. Among four stereoisomers of C16-ceramide, CERT specifically recognized the natural d-erythro isomer. CERT efficiently transferred ceramides having C14, C16, C18, and C20 chains, but not longer acyl chains, and also mediated efficient transfer of C16-dihydroceramide and C16-phyto-ceramide. Binding assays showed that CERT also recognizes short chain fluorescent analogs of ceramide with a stoichiometry of 1:1. Moreover, (1R,3R)-N-(3-hydroxy-1-hydroxymethyl-3-phenylpropyl)dodecamide, which inhibited the CERT-dependent pathway of ceramide trafficking in intact cells, was found to be an antagonist of the CERT protein. These results indicate that CERT can mediate transfer of various types of ceramides that naturally exist and their close relatives.
Review Article: A comparison of flood and earthquake vulnerability assessment indicators

In a cross-disciplinary study, we carried out an extensive literature review to increase understanding of vulnerability indicators used in the disciplines of earthquake- and flood vulnerability assessments. We provide insights into potential improvements in both fields by identifying and comparing quantitative vulnerability indicators grouped into physical and social categories. Next, a selection of index- and curve-based vulnerability models that use these indicators are described, comparing several characteristics such as temporal and spatial aspects. Earthquake vulnerability methods traditionally have a strong focus on object-based physical attributes used in vulnerability curve-based models, while flood vulnerability studies focus more on indicators applied to aggregated land-use classes in curve-based models. In assessing the differences and similarities between indicators used in earthquake and flood vulnerability models, we only include models that separately assess either of the two hazard types. Flood vulnerability studies could be improved using approaches from earthquake studies, such as developing object-based physical vulnerability curve assessments and incorporating time-of-the-day-based building occupation patterns. Likewise, earthquake assessments could learn from flood studies by refining their selection of social vulnerability indicators. Based on the lessons obtained in this study, we recommend future studies for exploring risk assessment methodologies across different hazard types.
Optimal adaptive sequential designs for crossover bioequivalence studies

In prior works, this group demonstrated the feasibility of valid adaptive sequential designs for crossover bioequivalence studies. In this paper, we extend the prior work to optimize adaptive sequential designs over a range of geometric mean test/reference ratios (GMRs) of 70–143% within each of two ranges of intra‐subject coefficient of variation (10–30% and 30–55%). These designs also introduce a futility decision for stopping the study after the first stage if there is sufficiently low likelihood of meeting bioequivalence criteria if the second stage were completed, as well as an upper limit on total study size. The optimized designs exhibited substantially improved performance characteristics over our previous adaptive sequential designs. Even though the optimized designs avoided undue inflation of type I error and maintained power at ≥ 80%, their average sample sizes were similar to or less than those of conventional single stage designs. Copyright © 2015 John Wiley & Sons, Ltd.
Self–Regulation and Well–Being: The Influence of Identity and Motives

The relationship between self–regulatory capacities and self–esteem as well as well–being is examined by a mediation model that views self–regulation as promoting the development of identity achievement which, in turn, is expected to be associated with well–being. Among secondary school students (Study 1) identity achievement mediated the association between the self–regulatory capacity of attention control and self–esteem. In Study 2 (university students), the mediational effect of identity achievement was found for the relationship between the self–regulatory capacity of action control and well–being. Explicit motives moderated this association. In sum, a firm identity enhances well–being by lending a sense of continuity to one's life. However, explicit motives have a substitution effect by giving direction to life when lacking firm identity commitments. Copyright © 2010 John Wiley & Sons, Ltd.
An Efficient Robust Solution to the Two-Stage Stochastic Unit Commitment Problem

This paper provides a reformulation of the scenario-based two-stage unit commitment problem under uncertainty that allows finding unit-commitment plans that perform reasonably well both in expectation and for the worst case. The proposed reformulation is based on partitioning the sample space of the uncertain factors by clustering the scenarios that approximate their probability distributions. The degree of conservatism of the resulting unit-commitment plan (that is, how close it is to the one provided by a purely robust or stochastic unit-commitment formulation) is controlled by the number of partitions into which the said sample space is split. To efficiently solve the proposed reformulation of the unit-commitment problem under uncertainty, we develop two alternative parallelization and decomposition schemes that rely on a column-and-constraint generation procedure. Finally, we analyze the quality of the solutions provided by this reformulation for a case study based on the IEEE 14-node power system and test the effectiveness of the proposed parallelization and decomposition solution approaches on the larger IEEE 3-Area RTS-96 power system.
Evolutionary history of HIV-1 subtype B and F infections in Brazil

Objective:To reconstruct the onset date of the HIV-1 B and F epidemics in Brazil based on virus diversification over time. Design:We studied HIV-1 env V3 sequences (210nt) with a known sampling year isolated from HIV-1 positive patients from Brazil between 1989 and 1997: 101 subtype B sequences and 41 subtype F sequences. Methods:HIV-1 V3 env sequences were grouped by year of collection and the relationship between the sampling years of HIV-1 sequences and their genetic distance to the reconstructed common ancestor (intra-population divergence) or to other sequences from the same year (intra-population diversity) was examined by using linear regression analysis. Results:Regression analysis of nucleotide distances, revealed a highly significant positive correlation between sampling years of subtype B and F V3 sequences and their intra-population divergence (P < 0.001) or diversity (P < 0.0001). In both subtype populations, the divergence and diversity increased at a rate of 0.5 and 0.9% per year, respectively. Considering these evolutionary rates, we estimate the onset of the subtype B and F HIV-1 epidemics in Brazil during early 1970s and early 1980s, respectively. Conclusions:The consistent correlation between divergence and diversity of the V3 sequences with their sampling years indicates that the molecular clock is operational in the evolution of the HIV-1 in Brazil's epidemic, and show that subtypes B and F are evolving at a similar rate over time. The dating results suggest a discontinuous introduction of these subtypes in the Brazilian population.
FOXP1: a potential therapeutic target in cancer

Forkhead Box P1 (FOXP1) is a member of the FOX family of transcription factors which have a broad range of functions. Foxp1 is widely expressed and has been shown to have a role in cardiac, lung and lymphocyte development. FOXP1 is targeted by recurrent chromosome translocations and its overexpression confers a poor prognosis in a number of types of lymphomas, suggesting it may function as an oncogene. In contrast, FOXP1 localises to a tumour suppressor locus at 3p14.1 and loss of FOXP1 expression in breast cancer is associated with a worse outcome, suggesting FOXP1 may function as a tumour suppressor in other tissue types. These data suggest that FOXP1 may not only be useful in prognosis but also may be used to develop FOXP1-directed therapeutic strategies.
Effect of heliox breathing on dynamic hyperinflation in COPD patients.

BACKGROUND and objective: Patients with COPD exhibit increased inspiratory work and dyspnea due to dynamic hyperinflation caused by expiratory flow limitation. Helium-oxygen mixtures (ie, heliox) have been used in treating these patients on the assumption that, by lowering airway resistance, they might be beneficial. METHODS In 22 patients with COPD, the presence of expiratory flow limitation was assessed with patients in the sitting and supine positions using the negative expiratory pressure technique, and the effects of heliox (80% He, 20% O2) on breathing pattern, expiratory flow limitation, and dynamic hyperinflation, evaluated from the change in inspiratory capacity (IC), were measured at rest and were compared with those due to inhaled salbutamol. RESULTS During air breathing, 13 patients experienced flow limitation while in the sitting position and 18 experienced flow limitation while in the supine position. Neither heliox nor salbutamol therapy changed the breathing pattern in any of the patients, regardless of posture and the presence or absence of expiratory flow limitation. However, in both positions IC increased significantly in most flow-limited patients after bronchodilator administration, but not after heliox administration. CONCLUSIONS Since heliox had no effect on dynamic hyperinflation, the use of this gas mixture, which is costly and cumbersome, does not appear to be beneficial in stable patients with COPD breathing at rest.