Miracle-dz/UniFAR-FTUs huggingface dataset:
The Extent and Determinants of Tax Gap in the Informal Sector: Evidence from Ghana: Extent and Determinants of Tax Gap in the Informal Sector

In this paper, we attempt to estimate the tax gap in the informal sector as well as the contributing factors of the tax losses in SSA countries using Ghana as a case study. Using micro data on non‐farm household enterprises obtained from the sixth round of the Ghana Living Standards Survey as well as data on quarterly tax payable by specified small scale enterprises derived from the Small Tax Payer office of the Ghana Revenue Authority, the findings show that the national potential and actual taxes in the informal sector are US$ 81 974 846 and US$ 25 023 273, respectively, reflecting an estimated national tax gap or loss of approximately US$ 56 951 573. Firm level variables such as type of business, urban location and experience of the firm significantly increase the propensity to pay tax and reduce the tax gap. Copyright © 2018 John Wiley & Sons, Ltd.
ER quality control of immune receptors and regulators in plants

Like in animals, cell surface and intracellular receptors mediate immune recognition of potential microbial intruders in plants. Membrane‐localized pattern recognition receptors (PRRs) initiate immune responses upon perception of cognate microbe‐associated molecular patterns (MAMPs). MAMP‐triggered immunity provides a first line of defence that restricts the invasion and propagation of both adapted and non‐adapted pathogens. The Leu‐rich repeat (LRR) receptor protein kinases (RKs) define a major class of trans‐membrane receptors in plants, of which some members are engaged in MAMP recognition and/or defence signalling. The endoplasmic reticulum (ER) quality control (QC) systems monitor N‐glycosylation and folding states of the extracellular, ligand‐binding LRR domains of LRR‐RKs. Recent progress reveals a critical role of evolutionarily conserved ERQC components for different layers of plant immunity. N‐glycosylation appears to play a role in ERQC fidelity rather than in ligand binding of LRR‐RKs. Moreover, even closely related PRRs show receptor‐specific requirements for N‐glycosylation. These findings are reminiscent of the earlier defined function of the cytosolic chaperon complex for LRR domain‐containing intracellular immune receptors. QC of the LRR domains might provide a basis not only for the maintenance but also for diversification of recognition specificities for immune receptors in plants.
Trade Linkages and Output‐Multiplier Effects: a Structural VAR Approach with a Focus on Asia

This paper develops a structural VAR model to measure how a shock to one country affects other countries' GDP. It uses trade linkages to estimate the multiplier effects as a shock is transmitted through output fluctuations and introduces a new specification strategy that reduces the number of unknowns and allows cross-country relationships to vary over time. This model is used to examine the impact of shocks to 11 Asian countries, the US, and the rest of the OECD. Impulse-response matrices suggest that these multiplier effects are large and can transmit shocks in very different patterns than predicted from a bilateral-trade matrix. Copyright Blackwell Publishing Ltd 2005.
Prospective evaluation of 99mTc-IDA cholescintigraphy and gray-scale ultrasound in the diagnosis of acute cholecystitis.

Prospective analysis of the efficacy of 99mTc-IDA cholescintigraphy and cholecystosonography showed that both are excellent techniques for assessing patients with suspected acute cholecystitis (accuracy 84.7% and 88.1% respectively). Consequently, the choice of tests selected to evaluate patients with suspected acute cholecystitis depends on several factors including; (a.) quality of equipment available; (b.) capability of the technologist performing the examination; (c.) relative experience of the physician supervising the examination; and (d.) willingness of the surgical consultant to accept a positive examination as sufficient evidence to perform emergency surgery. The authors feel that cholecystosonography should be used to assess the presence of acute cholecystitis in jaundiced patients because of its capability in the assessment of bile duct dilatation, and because of the lower reliability of cholescintigraphy when bile duct obstruction is possible (i.e., in jaundice). Ancillary findings in cholecystosonography and cholescintigraphy can aid in the differential diagnosis of acute right upper quandrant pain syndromes.
Political Institutions, State Capabilities, and Public Policy: An International Dataset (2014 Update)

The Database of Political Institutions presents institutional and electoral results data such as measures of checks and balances, tenure and stability of the government, identification of party affiliation and ideology, and fragmentation of opposition and government parties in the legislature, among others. The current version of the database, which is now hosted at the IDB, expands its coverage to about 180 countries for 40 years, 1975-2015. Researchers at the World Bank Development Research Group first compiled the database in 2000 (see citation information below). It has become one of the most cited databases in comparative political economy and comparative political institutions. Almost 3000 studies have used this database so far as a source of institutional and political data in their empirical analysis.
The impact of herbal remedies on adverse effects and quality of life in HIV-infected individuals on antiretroviral therapy.

INTRODUCTION Use of herbal remedies among HIV-infected individuals in Africa increased in the past decade, mainly due to traditional beliefs and at times inconsistent access to antiretroviral drugs. In Zimbabwe, accessibility and availability of antiretroviral drugs has increased in recent years; however, the use of herbal remedies remains high. This study was conducted to determine the impact of concomitant use of herbal remedies with antiretroviral drugs on adverse events and on quality of life. METHODOLOGY A convenient sample of HIV positive patients at Parirenyatwa group of hospitals' Family Care Clinic (Harare, Zimbabwe) was enrolled. A questionnaire was used to collect data on the adverse event experiences of the patients using herbal remedies for their HIV, as well as the types of herbal remedy used. Quality of life index was measured using an HIV/AIDS targeted quality of life (HAT-QOL) tool developed by the World Health Organization. RESULTS Abdominal pain (odds ratio = 2.7, p-value = 0.01) and rash (odds ratio = 2.5, p-value = 0.02) had significant associations with using herbal remedies during antiretroviral therapy. Improved quality of life index was not significantly associated with herbal remedy use during antiretroviral therapy. CONCLUSIONS There is evidence to suggest that some traditional herbal remedies used in Zimbabwe may increase incidence of certain types of adverse events when used in combination with antiretroviral drugs. Use of herbal drugs in combination with antiretroviral therapy does not significantly improve quality of life index in comparison to antiretroviral drug use only.
[Herpes labialis and genitalis in general medicine].

OBJECTIVE The purpose of this study was to determine the respective importance of herpes labialis and genitalis in patients consulting general practitioners and ascertain their knowledge and opinions concerning herpes labialis and genitalis in order to analyze patient behavior in case of flare-ups. PATIENTS AND METHOD A questionnaire was proposed to a representative sample of patients aged 15 years and older seen at consultation by 49 general practitioners participating in the General Medicine Observatory of the French Society of General Practitioners. RESULTS Among the 4,403 patients who responded, a known history of herpes labialis was reported by 39. 9 p.100 and of herpes genitalis by 2.5 p.100. Their answers to the questions demonstrated insufficient knowledge of avoidable risks of herpes as a sexually transmitted disease, with very significant misunderstanding by men. Among the 1,711 patients who had experienced herpes labialis, 62.9 p.100 initiated self-medication, 29 p.100 preferred to wait and see and 7.5 p.100 sought medical assistance. Among the 108 patients who had experienced herpes genitalis, at the last flare-up 40 p.100 initiated self-medication, 7.5 p.100 preferred to wait and see and 52 p.100 sought medical assistance. The general practitioner was the first physician consulted for both types of herpes. DISCUSSION This study illustrates the importance of herpes infections in the general medicine patients. It also confirms that new interventional strategies are needed both for health care and for health education.
Immunization status and birth order.

OBJECTIVE To determine whether an association exists between immunization status and birth order. DESIGN Medical record review of immunization dates for matched siblings. SETTING Pediatric clinic at a university medical center. SUBJECTS A total of 892 children (446 sibling pairs of firstborn and secondborn children) born between 1983 and 1991 who received regular pediatric care at the clinic. OUTCOME MEASURES Median ages at which firstborn children and their secondborn siblings had been immunized with the initial four doses of diphtheria and tetanus toxoids and pertussis vaccine (DTP1, DTP2, DTP3, and DPT4) and the initial dose of measles-mumps-rubella vaccine; point prevalences of firstborn and secondborn children up-to-date with all immunizations at each month of life to 2 years of age. RESULTS Between 5 and 12 months of life, the percentage of secondborn children who were fully immunized was significantly lower than the percentage of fully immunized firstborn children (P values ranging from < .0001 to < .05). Firstborn children were much more likely than their secondborn siblings to have been immunized on time with DTP2 (z = 3.80, P = .0001) and DTP3 (z = 3.31, P = .0009). Overall, DTP2 immunizations were given at median ages 10 days later, and DTP3 immunizations, 20 days later to secondborn children than to their firstborn siblings. In addition, late immunization of a firstborn child was found to increase the risk that a secondborn sibling would also be immunized late. CONCLUSIONS Secondborn children are likely to be immunized later than firstborn children. Secondborn children with an older sibling who was immunized late are at particular risk for delayed immunizations.
Development of Tight Junction Molecules in Blood Vessels of Germinal Matrix, Cerebral Cortex, and White Matter

Tight junction (TJ) molecules confer cell-to-cell adhesion to endothelial cells and, thus, provide structural integrity to blood vessels. Therefore, decreased expression of these molecules may be a cause of germinal matrix (GM) fragility and their propensity to hemorrhage in premature infants. The objective of this study was to compare the expression of endothelial TJ molecules, including claudin-5, occludin, and junction adhesion molecules (JAM), among blood vessels of GM, cortex, and white matter for fetuses and premature infants of gestational age 16–40 wk, and to examine their maturational changes with advancing gestational age. We measured the expression of claudin-1, claudin-5, occludin, and JAM in GM, cortex, and white matter in postmortem brain samples. We performed immunohistochemical staining on brain sections and Western blot to quantify these molecules. We found that claudin-5, occludin, and JAM-1 were expressed as early as 16 wk in GM, cortex, and white matter. Claudin-1, JAM-2, and JAM-3 were not detected in the GM, cortex, and white matter. Claudin-5, occludin, and JAM-1 did not change significantly as a function of gestational age. There was no significant difference in the expression of these molecules in the vasculature of GM compared with cortex and white matter. Because the primary endothelial TJ molecules, including claudin-5, occludin, and JAM-1, are expressed as early as 16 wk in the blood brain barrier and since as they are not decreased in GM vasculature compared with cortex and white matter, they are unlikely to be responsible for GM fragility and vulnerability to hemorrhage in premature infants.
Diabetic peripheral neuropathy and depressive symptoms: the association revisited.

OBJECTIVE We examined the association between severity of diabetic peripheral neuropathy and depressive symptoms and investigated the potential mediators of this association. RESEARCH DESIGN AND METHODS The Hospital Anxiety and Depression Scale (HADS) was used to assess depressive symptoms in 494 patients (mean age 62 years; 70% male; 72% type 2 diabetic) with diabetic neuropathy diagnosed by the Neuropathy Disability Score (NDS) and the Vibration Perception Threshold (VPT). Diabetic neuropathy symptoms, activities of daily living (ADLs), and social self-perception were measured by the neuropathy and foot ulcer-specific quality-of-life instrument, NeuroQoL; perceptions of diabetic neuropathy symptom unpredictability and the lack of effective treatment were assessed by the revised Illness Perception Questionnaire. RESULTS Both the NDS and VPT were significantly associated with the HADS after controlling for demographic and disease variables. Although diabetic neuropathy symptoms mediated this association, with unsteadiness being most strongly associated with HADS, the relationship between foot ulceration and depression was nonsignificant. The association between diabetic neuropathy symptoms and HADS was partially mediated by two sets of psychosocial variables: 1) perceptions of diabetic neuropathy symptom unpredictability and the lack of treatment control and 2) restrictions in ADLs and changes in social self-perception. CONCLUSIONS These findings establish the association between diabetic neuropathy and depressive symptoms and identify potential targets for interventions to alleviate depressive symptoms in persons affected by diabetic peripheral neuropathy.
Desflurane: A clinical update of a third‐generation inhaled anaesthetic

Available volatile anaesthetics are safe and efficacious; however, their varying pharmacology provides small but potentially clinically important differences. Desflurane is one of the third‐generation inhaled anaesthetics. It is the halogenated inhaled anaesthetic with the lowest blood and tissue solubilities, which promotes its rapid equilibration and its rapid elimination following cessation of administration at the end of anaesthesia. The low fat solubility of desflurane provides pharmacological benefits, especially in overweight patients and in longer procedures by reducing slow compartment accumulation. A decade of clinical use has provided evidence for desflurane's safe and efficacious use as a general anaesthetic. Its benefits include rapid and predictable emergence, and early recovery. In addition, the use of desflurane promotes early and predictable extubation, and the ability to rapidly transfer patients from the operating theatre to the recovery area, which has a positive impact on patient turnover. Desflurane also increases the likelihood of patients, including obese patients, recovering their protective airway reflexes and awakening to a degree sufficient to minimise the stay in the high dependency recovery area. The potential impact of the rapid early recovery from desflurane anaesthesia on intermediate and late recovery and resumption of activities of daily living requires further study.
Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A

Improved protein-based vaccines should facilitate the goal of effective vaccines against HIV and other pathogens. With respect to T cells, the efficiency of immunization, or “immunogenicity,” is improved by targeting vaccine proteins to maturing dendritic cells (DCs) within mAbs to DC receptors. Here, we compared the capacity of Langerin/CD207, DEC205/CD205, and Clec9A receptors, each expressed on the CD8+ DC subset in mice, to bring about immunization of microbial-specific T cells from the polyclonal repertoire, using HIV gag-p24 protein as an antigen. α-Langerin mAb targeted splenic CD8+ DCs selectively in vivo, whereas α-DEC205 and α-Clec9A mAbs targeted additional cell types. When the mAb heavy chains were engineered to express gag-p24, the α-Langerin, α-DEC205, and α-Clec9A fusion mAbs given along with a maturation stimulus induced comparable levels of gag-specific T helper 1 (Th1) and CD8+ T cells in BALB/c × C57BL/6 F1 mice. These immune T cells were more numerous than targeting the CD8− DC subset with α-DCIR2-gag-p24. In an in vivo assay in which gag-primed T cells were used to report the early stages of T-cell responses, α-Langerin, α-DEC205, and α-Clec9A also mediated cross-presentation to primed CD8+ T cells if, in parallel to antigen uptake, the DCs were stimulated with α-CD40. α-Langerin, α-DEC205, and α-Clec9A targeting greatly enhanced T-cell immunization relative to nonbinding control mAb or nontargeted HIV gag-p24 protein. Therefore, when the appropriate subset of DCs is targeted with a vaccine protein, several different receptors expressed by that subset are able to initiate combined Th1 and CD8+ immunity.
The obese brain: Association of body mass index and insulin sensitivity with resting state network functional connectivity

Obesity is a key risk factor for the development of insulin resistance, Type 2 diabetes and associated diseases; thus, it has become a major public health concern. In this context, a detailed understanding of brain networks regulating food intake, including hormonal modulation, is crucial. At present, little is known about potential alterations of cerebral networks regulating ingestive behavior. We used “resting state” functional magnetic resonance imaging to investigate the functional connectivity integrity of resting state networks (RSNs) related to food intake in lean and obese subjects using independent component analysis. Our results showed altered functional connectivity strength in obese compared to lean subjects in the default mode network (DMN) and temporal lobe network. In the DMN, obese subjects showed in the precuneus bilaterally increased and in the right anterior cingulate decreased functional connectivity strength. Furthermore, in the temporal lobe network, obese subjects showed decreased functional connectivity strength in the left insular cortex. The functional connectivity magnitude significantly correlated with body mass index (BMI). Two further RSNs, including brain regions associated with food and reward processing, did not show BMI, but insulin associated functional connectivity strength. Here, the left orbitofrontal cortex and right putamen functional connectivity strength was positively correlated with fasting insulin levels and negatively correlated with insulin sensitivity index. Taken together, these results complement and expand previous functional neuroimaging findings by demonstrating that obesity and insulin levels influence brain function during rest in networks supporting reward and food regulation. Hum Brain Mapp, 2011. © 2011 Wiley‐Liss, Inc.
Parenting stress and children with heart disease.

INTRODUCTION Whereas the stress precipitated by the diagnosis of an infant's congenital abnormality is well recognized, this study examined parenting stress reported by parents of children older than 2 years with heart disease. METHOD Abidin's Parenting Stress Index was administered to parents of children ages 2 to 12 years with known heart disease during a cardiology outpatient clinic visit. RESULTS Parents of children with heart disease were more likely than the normative population to report excessive parenting stress, especially related to characteristics of the child that make them difficult to parent. Approximately 1 in 5 parents expressed clinically significant levels of stress. These parents expressed difficulty with setting limits or discipline of the child with heart disease. Parenting stress was not related to the severity of the child's heart disease, family socioeconomic status, or time since most recent surgery. Older age of the child was associated with higher parenting stress scores. DISCUSSION Clinicians must assess parenting stress at each health care visit to provide appropriate support and anticipatory guidance to families of children with heart disease.
Physiology of Cold Hardiness, Seasonal Fluctuations, and Cryoprotectant Contents in Overwintering Adults of Hypera postica (Coleoptera: Curculionidae)

Abstract The alfalfa weevil, Hypera postica (Gyllenhal), is widely distributed in various alfalfa-growing regions in the world. Adults enter the field gradually from hibernation places and overwinter in a nondiapausing state, exhibiting feeding, mating, and oviposition over autumn and winter whenever the weather permits. In this study, the variability of supercooling point (SCP) and cold hardiness in alfalfa weevil was investigated. Adults were collected monthly from alfalfa fields in Karaj, Iran, during autumn, winter, and spring in 2011–2012. Supercooling points and LT50 (exposure at subzero temperatures from -5 to -13 °C for 24h and 50% death of the sample) were studied. The average SCP varied from -14.4 ± 0.7 °C inOctober to -8.7 ± 0.4 °C in May. Mean SCPs were significantly lower during autumn (-13.4 °C) than winter months (-8.6 °C). The frequency distribution of SCPs in individuals in autumn was bimodal and in winter was unimodal. Insects could survive after exposure to -5 °C in all months, but mortality increased with cold intensity. Percent mortality at -11 °C was ∼89% in November and December and then increased to 100% in January and February. The approximate LT50 values were -5.7 °C and -6 °C in January and February, respectively. Seasonal changes in sorbitol, glycerol, glucose, and trehalose were consistent with a role in freeze protection. However, microhabitat may also play an important role in protecting insects from cold weather and allowing them to tolerate low temperatures and increase their population.
A canonical formulation for analyzing multielement unstable resonators

A simple but general formulation for the unified analysis of many different varieties of unstable optical resonators is obtained by expressing the round-trip Huygens' integral for the resonator in terms of the round-trip paraxial ray matrix. Complicated multielement resonators, ring resonators, and unstable resonators with variable-reflectivity output mirrors are thereby all reduced to a single equivalent collimated-beam diffraction problem. Essential assumptions in the analysis are that all elements in the resonator obey paraxial ray theory and that there is only one significant output coupler or limiting aperture per round trip inside the resonator. The only parameters needed to describe an arbitrary unstable resonator in this formulation are the round-trip magnificationMand either the equivalent Fresnel number Neqor else an equivalent collimated Fresnel numberN_{c} = [2M^{2}/(M^{2} - 1)] N_{eq}, plus for variable-reflectivity mirrors a specification of the mirror reflectivity profile.