Miracle-dz/UniFAR-FTUs huggingface dataset:
Risk of second primary malignancy after non-small cell lung cancer: a competing risk nomogram based on the SEER database.

Background With the improvement of survival for non-small cell lung cancer (NSCLC), research focused on second primary malignancy (SPM) in NSCLC survivors is becoming urgent. This study aimed to estimate the risk of SPM in NSCLC patients. Methods We retrospectively analysed NSCLC patients diagnosed between 2004 and 2010 in SEER database. We firstly evaluated the crude and cumulative incidence of SPM. SPM incidence in NSCLC survivors compared to that in the reference population was calculated as standardized incidence ratio (SIR). A competing risk nomogram was also built, to predict the incidence of SPM. Results The crude and 10-year cumulative incidences of SPM were 4.04% and 5.05%, respectively, while the SIR was 1.62. The nomogram was well calibrated and had good discriminative ability, with c-index of 0.80. It showed a significantly wide interval of SPM cumulative incidence between the first and tenth-decile according to the risk model (1.04% vs. 16.70%, P<0.05). The decision curve analysis indicated that the clinical net benefit of risk model was larger than that in other scenarios (all-screening or no-screening) in a range of threshold probabilities (1% to 20%). Conclusions Our study firstly performed a systematic estimation of the incidence of SPM in NSCLC, which implied the necessity of a risk predicting model. We developed the first competing risk nomogram to predict the risk of SPM, which performed well in the evaluation and might be helpful for individualized SPM screening.
An investigation of the relationship of beliefs, values and technological pedagogical content knowledge among teachers

ABSTRACT The purpose of this study was to investigate the relationship among student-centred beliefs, technology value beliefs and technological pedagogical content knowledge (TPACK) in junior high school mathematics teachers. A survey was administered to 408 teachers in Taiwan. Regression analysis results showed that teachers’ student-centred beliefs and technology values were significantly correlated with TPACK. MANOVA results found that teachers with high student-centred pedagogical beliefs may not have high technology values, and teachers with lower student-centred pedagogical beliefs may not have lower TPACK. Implications for professional development and suggestions regarding teachers’ beliefs and TPACK are discussed.
Adverse drug reactions of antineoplastic and immunomodulating agents reported to the Egyptian Pharmaceutical Vigilance Center

The aim of this study was to evaluate the pattern of Adverse Drug Reactions (ADRs) related to antineoplastic and immunomodulating agents in Egypt. We extracted all ADR reports of antineoplastic and immunomodulating agents (Anatomical Therapeutic Chemical (ATC) code L) that were reported to Egyptian Pharmaceutical Vigilance Center (EPVC) from January 2011 to December 2015 using VigiLyze TM. Afterwards, these reports were analyzed and categorized by age, sex, reporter qualification, seriousness, type of ADRs, medications, indications of use and causality. During the study period, 1905 reports related to antineoplastic and immunomodulating agents were received; 44.6% of which were reported by consumers and 56.8% by health care professionals. ADRs were serious in 13.3% and 65.1% of the cases reported by consumers and healthcare professionals, respectively. Approximately half (52.5%) of the reported ADRs occurred in females and only 8.4% occurred in children. Half of the reported ADRs ( 51.5%) occurred in middle aged group (45- 64 years). The most reported classes at the therapeutic level were immunostimulants (ATC code L03) and antineoplastic agents (ATC code L01). The most frequently reported medication was peg-interferon alfa-2a. The majority of ADRs were of the type "general disorders and administration site conditions" and "gastrointestinal disorders". In conclusion, ADRs caused by immunostimulants especially interferons have higher tendency to be reported in Egypt especially in the middle-aged group. Additionally, the study has shown that serious ADRs of antineoplastic and immunomodulating agents were more likely to be reported by healthcare professionals rather than consumers.
A systematic review of interventions for supporting partners of military Veterans with PTSD

Introduction: Partners of military Veterans with post-traumatic stress disorder (PTSD) and other mental health difficulties can themselves develop difficulties with stress, well-being, and secondary trauma. Various interventions exist which involve partners of military personnel, but very few with an explicit focus on the partners’ well-being. This article aims to conduct a systematic review of these interventions and outline the range of interventions and the outcomes measured. Methods: We conducted a systematic literature search, from which 25 papers were reviewed. Papers were included if they described any form of intervention in which a partner was involved, where the Veteran was described as having PTSD, and where the aim of the intervention was aimed at least partly at improving the well-being of partners. Results: We found various types of interventions, such as group-based interventions, residential retreats, couples therapies, Internet-based interventions, and family-based interventions. Of the 25 studies reviewed, 21 reported on well-being outcomes, either via randomized controlled trials (RCTs), evaluations, or case studies. In most cases, interventions reported improvements in the well-being of partners, although there were very few controlled studies. Only a small number of interventions were aimed solely at partners. The most common feature of interventions was psychoeducation on topics such as communication, problem solving, and emotion regulation. Many papers described the advantages of group processes such as social support and normalization, gained from partners sharing experiences with one another. Discussion: A wide range of formats exist of interventions for improving the well-being of military partners. The literature would benefit from more robust experimental research into their effectiveness, and exploration of interventions aimed directly at the well-being of partners.
Validation of a New Point Shear-Wave Elastography Method for Noninvasive Assessment of Liver Fibrosis: A Prospective Multicenter Study

Objective To validate the diagnostic value of a new point shear-wave elastography method, S-shearwave elastography (S-SWE; Samsung Medison Co., Ltd.), in noninvasive assessment of liver fibrosis. Materials and Methods In this prospective multicenter study, liver stiffness (LS) measurements for 600 participants were obtained with both S-SWE and transient elastography (TE). The rates of unsuccessful LS measurements in S-SWE and TE were compared, and correlations between S-SWE and TE measurements were assessed. In 107 patients with histologic reference data, the optimal LS cut-off values for predicting severe fibrosis and cirrhosis on S-SWE were determined using receiver operating characteristic (ROC) curve analysis. The LS cut-off values in S-SWE were then validated in 463 patients without histologic reference data by using TE values as the reference standard, and the sensitivity and specificity of the cut-off values for predicting severe fibrosis and cirrhosis were calculated. Results The frequency of unsuccessful LS measurements on TE (4.5%, 27/600) was significantly higher than that (0.7%, 4/600) on S-SWE (p < 0.001). LS measurements on S-SWE showed a significant correlation with TE values (r = 0.880, p < 0.001). In 107 patients with histological reference data, the areas under the ROC curves on S-SWE were 0.845 and 0.850, with optimal cut-offs of 7.0 kilopascals (kPa) and 9.7 kPa, for the diagnosis of severe fibrosis and cirrhosis, respectively. Using these cut-off values, S-SWE showed sensitivities of 92.9% and 97.4% and specificities of 89.5% and 83.1% in TE-based evaluations of severe fibrosis and cirrhosis, respectively. Conclusion LS measurements on S-SWE were well correlated with those on TE. In addition, S-SWE provided good diagnostic performance for staging of hepatic fibrosis, with a lower rate of unsuccessful LS measurements compared with TE.
Insects in food and feed – allergenicity risk assessment and analytical detection

Abstract Insects and insect‐based food products have entered in the European market, carrying along issues of safety and the need of establishing a new legal framework. The consumption of massively reared insects can pose chemical and microbiological risks, and insect proteins are likely to represent a hazard for a subpopulation of allergic individuals. All insect‐based products are considered ‘Novel Food’ and fall under EU regulation 2015/2283, according to which a specific application to the European Commission, followed by EFSA scientific evaluation, is needed before the product is put on the market. The recent EU Regulation 2017/893, entered into force on 1 July 2017, allowed a shortlist of seven insect species to be included in the formulation of feeds for aquaculture. Previously, the addition of any insect to any feed for farmed animals was not allowed, due to the risk of prion‐derived diseases. The introduction of this new Regulation raises the issue to switch from a classical detection method based on microscopy to a more sophisticated and species‐specific method. The overall aims of this EU‐FORA project were (i) to set up a new next generation sequencing (NGS)‐based molecular method for the identification of insect DNA in feeds for aquaculture; and (ii) to carry out a conceptual work on a probabilistic quantitative risk assessment focused on the allergenicity of yellow mealworm (Tenebrio molitor) employed in foods.
The Role of Matrix Metalloproteinase-2 Expression in Gastric Cancer Susceptibility: A Systematic Review

Context: Gastric carcinoma (GC) is the most commonly diagnosed cancer that has been one of the main causes of cancer death worldwide. The matrix metalloproteinase-2 (MMP2) gene was expressed in the gastric cancer tissues compared to the matched normal tissues that are associated with the metastasis of gastric cancer cells. Objectives: This systematic review was performed to investigate the role of MMP-2 in gastric cancer among the different population. Evidence Acquisition: We searched on electronic databases such as PubMed, Scopus, Science Direct and Cochrane Library Database without any language restriction for relevant publications which were published until April 2019. Results: Thirty two original and relevant studies that evaluate the association between gastric cancer and MMP-2 were included. This systematic review indicated that increased MMP-2 expression has been seen in gastric cancer. MMP-2 over-expression may play a crucial role in degrading extracellular matrix as well as stimulate angiogenesis. Conclusions: MMP2 over-expression can play a critical role in tumor metastasis, tumor size, invasion, and lymph node invasion in GC.
The inflammatory potential of diet and bladder cancer risk: results from a prospective cohort study.

With an estimated 430,000 new diagnoses and 165,000 deaths per year worldwide (1) and per patient treatment costs of over 100,000 US dollars (2), bladder cancer represents a major burden for patients and society. From a public health perspective, it would be desirable to identify preventable risk factors.
Clinicopathological spectrum of patients with lupus nephritis in a tertiary care hospital

aim: The aim is to determine the distribution of different classes of lupus nephritis based on renal biopsy and to correlate it with serum creatinine and proteinuria. Objectives: To study the prevalence of different classes of systemic lupus erythematosus (SLE) using the International Society of Nephrology/Renal Pathology Society (ISN/RPS) 2003 classification in our facility, and to determine the correlation between the histopathological features of different classes of lupus nephritis and the clinical and laboratory parameters. Material and methods: Renal biopsy specimens with a clinical diagnosis of SLE by ARA criteria in a period of 3 years received in the laboratory were included in the study and were classified according ISN/RPS 2003 classification. The clinical and laboratory data were obtained from patient files. results: Out of 40 patients, 35 (88%) were females and 5 (12%) were male patients. Mean age was 32.7±10.7 years. Majority of patients belong to class IV (53%) followed by class III (22%). conclusion: In this study the commonest class of International Society of Nephrology (ISN)/Renal Pathology Society (RPS) classification is class IV and there is significant correlation between 24 h proteinuria with ISN/ RPS classes.
Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) Combined with Aerobic Exercise on the Recovery of Motor Function in Ischemic Stroke Rat Model

The therapeutic benefits of repetitive transcranial magnetic stimulation (rTMS) combined with rehabilitation therapy on recovery after stroke have not been fully elucidated. This study aimed to explore the therapeutic effects of rTMS followed by aerobic exercise on neuroplasticity and recovery of motor function in a rat model of permanent middle cerebral artery occlusion (MCAO). Rats were randomized into sham operation (N = 10, sham op), MCAO (N = 10, control group), rTMS (N = 10, MCAO and rTMS therapy), and combination groups (N = 10, MCAO and combination therapy). High-frequency rTMS (10 Hz) was applied on the ipsilesional forepaw motor cortex, and aerobic exercise training on the rotarod was performed for two weeks. The rotarod and Garcia tests were conducted to evaluate changes in behavioral function. Motor evoked potentials (MEPs) were used to evaluate electrophysiological changes. Stroke severity was assessed using infarction volume measurement. Neuronal recovery was explored with western blot for brain-derived neurotrophic factor (BDNF) pathway proteins. Compared with control therapy, combination therapy was significantly more effective than rTMS therapy for improving function on the rotarod test (p = 0.08), Garcia test (p = 0.001), and MEP amplitude (p = 0.001) In conclusion, combination therapy may be a potential treatment to promote recovery of motor function and neuroplasticity in stroke patients.
Cumulative dietary exposure assessment of pesticides that have acute effects on the nervous system using SAS ® software

Abstract Retrospective dietary exposure assessments were conducted for two groups of pesticides that have acute effects on the nervous system: brain and/or erythrocyte acetylcholinesterase inhibition, and functional alterations of the motor division. The pesticides considered in this assessment were identified and characterised in the scientific report on the establishment of cumulative assessment groups of pesticides for their effects on the nervous system. The exposure assessments used monitoring data collected by Member States under their official pesticide monitoring programmes in 2014, 2015 and 2016 and individual food consumption data from 10 populations of consumers from different countries and from different age groups. Exposure estimates were obtained for each group of pesticides by means of a 2‐dimensional Monte Carlo simulation, which was implemented in SAS ® software. Results were validated against exposure estimates obtained by the Dutch National Institute for Public Health and the Environment (RIVM) using the Monte Carlo Risk Assessment (MCRA) software. Both tools produced nearly identical results and minor differences were mainly attributed to the random effect of probabilistic modelling. The exposure estimates obtained in this report are used in the final scientific report on the cumulative dietary risk characterisation of pesticides that have acute effects on the nervous system. The latter combines the hazard assessment and exposure assessment into a consolidated risk characterisation including all related uncertainties.
Anxiety and cortisol levels during circumcision

DOI: 10.4328/JCAM.6106 Received: 08.12. 2018 Accepted: 25.01. 2019 Published Online: 29.01. 2019 Printed: 01.01. 2020 Ann Clin Anal Med 2020;11(1):24-27 Corresponding Author: Duygu Kara, Anesthesiology and Reanimation Unit, Palandoken Government Hospital, Postal Zip Code: 06230, Erzurum, Turkey. GSM: +905069288141 T. : +90 4422325000 F. : +90 4422325000 E-Mail: drduygukara@yahoo.com ORCID ID: https://orcid.org/0000-0003-3325-2565 Abstract Aim: In this study, we aimed to investigate whether circumcision is a stressor ambulatory surgical intervention for children and demonstrate the relationship between preand post-operative anxiety levels, blood cortisol levels (BCL), and salivary cortisol levels (SCL) in these children. Material and Method: Boys aged between 5 and 17 years, with a plan of circumcision, were prospectively included. Their preoperative anxiety levels, salivary cortisol levels (SCL), and blood total cortisol levels (BCL) were measured. After the operation, the same parameters were measured and preoperative values were compared with postoperative values. Also, the correlation between anxiety scores, SCL, and BCL was assessed. The Yale Preoperative Anxiety Scale was used to calculate the anxiety scores. Results: The mean age of 81 patients was 6.62 ± 1.40 years. The preoperative anxiety scores, SCL, and BCL were significantly lower than post-operative values (p<0.001 for each). The preoperative SCL were positively correlated with BCL and anxiety scores. Postoperative SCL were positively correlated with BCL and anxiety scores. Discussion: Circumcision is a cause of increment in anxiety, serum, and salivary cortisol levels in children. Salivary cortisol levels were correlated with simultaneously drawn serum cortisol levels. The preoperative and postoperative anxiety scores were correlated with BCL and SCL in children with circumcision operation.
Phonological Awareness and Rapid Automatized Naming as Longitudinal Predictors of Reading in Five Alphabetic Orthographies with Varying Degrees of Consistency

ABSTRACT Although phonological awareness (PA) and rapid automatized naming (RAN) are confirmed as early predictors of reading in a large number of orthographies, it is as yet unclear whether the predictive patterns are universal or language specific. This was examined in a longitudinal study across Grades 1 and 2 with 1,120 children acquiring one of five alphabetic orthographies with different degrees of orthographic complexity (English, French, German, Dutch, and Greek). Path analyses revealed that a universal model could not be confirmed. When we specified the best-fitting model separately for each language, RAN was a consistent predictor of reading fluency in all orthographies, whereas the association between PA and reading was complex and mostly interactive. We conclude that RAN taps into a language-universal cognitive mechanism that is involved in reading alphabetic orthographies (independent of complexity), whereas the PA–reading relationship depends on many factors like task characteristics, developmental status, and orthographic complexity.
Handling missing continuous outcome data in a Bayesian network meta-analysis

Background: A Bayesian network meta-analysis (NMA) model is a statistical method aimed at estimating the relative effects of multiple interventions against the same disease. The method has recently gained prominence, leading to the synthesis of the evidence regarding rank probabilities for each treatment. In several cases, an NMA is performed excluding incomplete data of studies retrieved through a systematic review, resulting in a loss of precision and power. Methods: There are several methods for handling missing or incomplete data in an NMA framework, especially for continuous outcomes. In certain cases, only baseline and follow-up measurements are available; in this framework, to obtain data regarding mean changes, it is necessary to consider the pre-post study correlation. In this context, in a Bayesian setting, several authors suggest imputation strategies for pre-post correlation. In other cases, a variability measure associated with a mean change score might be unavailable. Different imputation methods have been suggested, such as those based on maximum standard deviation imputation. The purpose of this study is to verify the robustness of Bayesian NMA models concerning different imputation strategies through simulations. Results: Simulation results show that the bias is notably small for every scenario, confirming that rankings provided by models are robust concerning different imputation methods in several heterogeneity-correlation settings. Conclusions: This NMA method seems to be more robust to missing data imputation when data reported in different studies are generated in a low-heterogeneity scenario. The NMA method seems to be more robust to missing value imputation if the expectation of the prior distribution, defined on the heterogeneity parameter, approaches the true value of the variability across studies.
IV. Influence of ingestion of cholesterol in the form of eggs on the composition of bile in healthy subjects

The fact that ingestion of cholesterol in an easily absorbable form such as egg yolk tends to increase serum cholesterol in man is well established (1), but the possible influence of dietary cholesterol on the composition of human bile does not seem to have been examined. The experiments described in the present paper were carried out in order to ascertain whether daily intake of a substantial amount of cholesterol in the form of whole eggs markedly influences the composition of bile in healthy subjects especially with respect to the molar percentages of each of the main bile acids in the total bile acids and the molar ratios between total bile acids and cholesterol, between lipidsoluble phosphorus and cholesterol, and between total bile acids and lipid-soluble phosphorus.
Polyhedral Compilation: Applications,Approximations and GPU-specific Optimizations

Polyhedral compilation has been successful in analyzing, optimizing, automatically parallelizing a�ne computations for modern heterogenous target architectures. Many of the tools have been developed to automate the process of program analysis and transformations for a�ne control parts of programs including widely used open-source and production compilers such as GCC, LLVM, IBM/XL. This thesis makes contribution to the polyhedral model in three orthogonal dimensions as follows: • Applications: Applies polyhedral loop transformations on Deep learning computation kernel to demonstrate the e�ectiveness of complex loop transformations on these kernels. • Approximations: Developes two efficient algorithms to over-approximate convex polyhedra into U-TVPI polyhedra having applications in polyhedral compilation as well as automated program verification. • GPU-Specific Optimizations: Builds end-to-end fully automatic compiler framework to generate cache optimized CUDA code begining from sequential C program by using polyhedral modelling techniques. x