Miracle-dz/UniFAR-FTUs huggingface dataset:
Influence of Different β-Blockers on Platelet Aggregation in Patients With Coronary Artery Disease on Dual Antiplatelet Therapy

Introduction: The use of β-blockers in the treatment of patients with coronary heart disease is associated with a decrease in the frequency of angina pectoris and mortality of patients. Due to the severity of the disease and previous cardiovascular interventions, many patients with coronary artery disease (CAD) use dual antiplatelet therapy to achieve greater inhibition of platelet aggregation. The influence of β-blockers on platelet aggregation in patients using antiplatelet therapy is not well understood. Objective: To examine the effect of different β-blockers on platelet aggregation in patients on dual antiplatelet therapy. Methodology: The study included 331 patients who were treated at the Department of Cardiology, Clinical Center Kragujevac during 2011. Patients were divided into 4 groups depending on the type of β-blockers that were used (bisoprolol, nebivolol, metoprolol, and carvedilol). Platelet aggregation was measured using the multiplate analyzer and expressed through the value of adenosine diphosphate (ADP) test (to assess the effect of clopidogrel), ASPI test (to assess the effect of acetyl salicylic acid), TRAP test (to assess baseline platelet aggregation), and the ratio of ADP/TRAP and ASPI/TRAP ASPI/TRAP (ASPI - aranchidonic acid induced aggregation, TRAP - thrombin receptor activating peptide) representing the degree of inhibition of platelet aggregation compared to the basal value. In consideration were taken the representation of demographic, clinical characteristics, laboratory parameters, and cardiovascular medications between the groups. Results: Patients who used nebivolol had a significantly lower value of the ratio of ADP/TRAP (0.39 ± 0.30) compared to patients who used bisoprolol (0.48 ± 0.26; P = .038), and trend toward the lower values of ADP test (328.0 ± 197.3 vs 403.7 ± 213.2; P = .059), while there was no statistically significant difference in values of other laboratory parameters of platelet function between other groups. Conclusion: Patients with CAD on dual antiplatelet therapy who used nebivolol had significantly lower levels of residual ADP-induced platelet aggregation compared to baseline than patients who used bisoprolol.
The genetics of skin cancer

Recent advances in molecular genetics have led to a better understanding of the biological underpinnings of skin cancer formation. As with most cancers, the RB, p53, and RAS pathways appear to play prominent roles in the pathogenesis of several skin cancer types. Although various components of these pathways may be differentially altered in squamous cell carcinoma (SCC), basal cell carcinoma (BCC), and cutaneous melanoma, the final biochemical expression of these defects may be the same. With the unraveling of these genetic mechanisms, a more targeted approach to diagnosis and treatment may be possible in the near future. © 2004 Wiley‐Liss, Inc.
The Drivers of Capital Flows in Emerging Markets Post Global Financial Crisis

The paper studies the determinants of various instruments of capital flows, using 34 emerging markets and developing economies over 2009Q3–2015Q4. The regressions are extended to focus on quarters with flows that are one standard deviation above/below mean. Overall, the capital flow slowdown in recent years is due to lower growth prospects of recipient countries and worsening global risk sentiment. However, there are considerable differences across instruments. The sensitivity of some flows, towards push/pull factors, increases during periods of extreme capital flows. The gap between the US long- and short-term maturity bond yields — insignificant during normal times — is important during high capital flow episodes.
Redox regulation of the yeast voltage-gated Ca2+ channel homolog Cch1p by glutathionylation of specific cysteine residues

ABSTRACT Cch1p, the yeast homolog of the pore-forming subunit α1 of the mammalian voltage-gated Ca2+ channel (VGCC), is located on the plasma membrane and mediates the redox-dependent influx of Ca2+. Cch1p is known to undergo both rapid activation (after oxidative stress and or a change to high pH) and slow activation (after ER stress and mating pheromone activation), but the mechanism of activation is not known. We demonstrate here that both the fast activation (exposure to pH 8–8.5 or treatment with H2O2) and the slow activation (treatment with tunicamycin or α-factor) are mediated through a common redox-dependent mechanism. Furthermore, through mutational analysis of all 18 exposed cysteine residues in the Cch1p protein, we show that the four mutants C587A, C606A, C636A and C642A, which are clustered together in a common cytoplasmic loop region, were functionally defective for both fast and slow activations, and also showed reduced glutathionylation. These four cysteine residues are also conserved across phyla, suggesting a conserved mechanism of activation. Investigations into the enzymes involved in the activation reveal that the yeast glutathione S-transferase Gtt1p is involved in the glutathionylation of Cch1p, while the thioredoxin Trx2p plays a role in the Cch1p deglutathionylation. Summary: Cch1p, the yeast homolog of the pore-forming subunit α1 of mammalian VGCCs, is regulated by redox-dependent glutathionylation and deglutathionylation (mediated by Gtt1p, and Grx1p and Trx2p, respectively) of cysteine residues.
[Menarche, early pregnancy, and obesity in selected Brazilian women from a health care center in Belo Horizonte, Minas Gerais, Brazil].

The aim of this study was to investigate obstetric variables potentially associated with obesity among 486 Brazilian childbearing-age women aged 15-59 residing in the municipality of Belo Horizonte, Minas Gerais State. Body fat (BF) was measured through impedance analysis, and obesity was defined as BF > 30%. The association between obstetrics factors and obesity was evaluated through multivariate logistic regression. The following variables remained in the logistic regression after adjustments for total income, smoking, alcohol consumption, and physical activity: age at menarche 30 and 40 years (OR = 3.32; 95% CI: 1.76-6.27), age at first childbirth (OR = 1.99; 95% CI: 1.07-3.68), and the following interaction: age group > 30 and < 39 and age at menarche (OR = 0.27; 95% CI: 0.09-0.83). It appears that obstetric factors affect obesity through a complex network of interrelations that involve the covariates studied above. It is important to support efficient programs to prevent obesity, as well as family planning programs emphasizing a reduction in the prevalence of teenage pregnancies.
Thermoacoustic tomography with integrating area and line detectors

Thermoacoustic (optoacoustic, photoacoustic) tomography is based on the generation of acoustic waves by illumination of a sample with a short electromagnetic pulse. The absorption density inside the sample is reconstructed from the acoustic pressure measured outside the illuminated sample. So far measurement data have been collected with small detectors as approximations of point detectors. Here, a novel measurement setup applying integrating detectors (e.g., lines or planes made of piezoelectric films) is presented. That way, the pressure is integrated along one or two dimensions, enabling the use of numerically efficient algorithms, such as algorithms for the inverse radon transformation, for thermoacoustic tomography. To reconstruct a three-dimensional sample, either an area detector has to be moved tangential around a sphere that encloses the sample or an array of line detectors is rotated around a single axis. The line detectors can be focused on cross sections perpendicular to the rotation axis using a synthetic aperture (SAFT) or by scanning with a cylindrical lens detector. Measurements were made with piezoelectric polyvinylidene fluoride film detectors and evaluated by comparison with numerical simulations. The resolution achieved in the resulting tomography images is demonstrated on the example of the reconstructed cross section of a grape.
A comparative analysis of the risk in Islamic and conventional banks in Kenya

Islamic Banking has grown rapidly throughout the world and has been introduced in more than 60 countries of the world so far However, scepticism still surrounds Islamic Banking keeping into view the earlier demise of other banks Since, Islamic banks can not charge a fixed return unrelated with their client's operations, it may seem that Islamic banks face more risk and hence, will have more volatile returns on their assets as they have to own the asset before they sale or lease it to their clients and take on subject matter risk which conventional banks do not take This study probes into whether Islamic banks are riskier than conventional banks or not The objective of this study is to establish whether Islamic banks in Kenya are riskier than the conventional banks This was a correlational study. The population was 43 commercial banks in Kenya Two purely Islamic banks and two other conventional banks were selected for the study Secondary data was used in this study Data was analysed using descriptive analysis, ttests, correlation analysis, and regression analysis I’he descriptive statistics showed that Islamic banks were riskier than conventional banks in terms o f ROE and operational risk while conventional banks were riskier than the Islamic banks in terms of credit risk and liquidity risk The one-way sample test showed that the overall risk (ROE) was not significantly different across the banks but the differences in credit risk, liquidity risk and operational risks were statistically significant across the banks The regression results showed that bank type has a negative influence on ROE, credit risk and operational risk while a positive effect on liquidity risk None of
Economic Growth, Foreign Investments and Exports in Romania: A VECM Analysis

The present paper deals with the relationship between GDP, FDI and merchandise exports using a vector error-correction model (VECM). The empirical model is based on quarterly data for the period 2005-2014 in Romania. The Granger causality test indicate a positive significant bidirectional relationship and between FDI and GDP and a unidirectional relationship between GDP and exports. The variance decomposition indicates that more than 50% of the fluctuations in FDI are explained by the shocks in GDP, while the influence of shocks in exports is quite low. Fluctuations in GDP are largely explained by the shocks occurring in this variable. As regards exports, 44% of fluctuations are due to FDI, while the impact of GDP reaches 13-15% after 10 quarters.
Use of microcredit for household income and consumption smoothing by low income communities

This paper discusses findings of a study that investigated income, savings and consumption patterns of low income people, and critical factors that influence the use of microcredit- a form of small instant loans targeted for low income people- for household income and consumption smoothing. The sample of the study consisted of households from low income communities living in a lower-middle income country- Sri Lanka. It was found that microcredit borrowers were using the loans for purposes that can be identified as income and consumption smoothing, which is beyond the ideas and intended practice of microcredit. The findings suggests that the consequences of using microcredit for income and consumption smoothing could be costly for households and the society at large. This article is protected by copyright. All rights reserved.
Repeated DNA Vaccinations Elicited Qualitatively Different Cytotoxic T Lymphocytes and Improved Protective Antitumor Effects

The use of DNA vaccines for generating antigen-specific CD8+ T cell responses has been well established. However, little is known about the quantitative and qualitative aspects of CD8+ T cell responses and protective immunity generated after repeated DNA vaccinations. We used human papillomavirus (HPV) type-16 E7 as a model tumor antigen in an E7-expressing tumor model, TC-1, to assess the influence of the frequency of DNA vaccinations on E7-specific immunological and antitumor responses. Mice were vaccinated with 1–4 inoculations of pcDNA3-E7 DNA. Immunological assays and tumor protection experiments were performed to assess the effect of repeated E7 DNA vaccination on E7-specific T cells and E7-expressing tumors. Our results demonstrated that mice receiving an increased number of E7 DNA vaccinations exhibited higher E7-specific CTL activity, a rapid expansion of E7-specific IFN-γ-secreting CD8+ T cells upon stimulation with E7 antigen, and a stronger antitumor effect against an E7-expressing tumor. Furthermore, we found that increasing the number of E7 DNA vaccinations followed by vaccinia booster enhanced the functional avidity of E7-specific CD8+ T cells. Our data suggest that quantitative and qualitative characteristics of antigen-specific CD8 + T cell responses and the ensuing protective antitumor effect can be influenced by the frequency of DNA vaccinations. These results have important clinical implications for the use of naked DNA vaccines in cancer immunotherapy.
CEO Retirement, Corporate Governance and Conditional Accounting Conservatism

Abstract Based on 16,604 observations between 1994 and 2006, this study revisits the ‘horizon problem’ by examining how CEO retirement affects conditional accounting conservatism. We hypothesize and find that firms become less conservative in their financial reporting before the retirement of their CEOs, and that strong corporate governance mitigates the effect of CEO retirement. The literature concerning the horizon problem has suggested that CEOs manipulate earnings to boost short-term performance before they leave their companies (Dechow, P. M., & Sloan, R. G. (1991). Executive incentives and the horizon problem: An empirical investigation. Journal of Accounting and Economics, 14(1), 51–89; Smith, C. W. , & Watts, R. L. (1982). Incentive and tax effects of executive compensation plans. Australian Journal of Management, 7(2), 139–157), but the evidence is mixed. By examining conditional conservatism, we avoid some of the methodological difficulties that confront researchers when examining either real or accrual earnings management. Ours is the first study to provide evidence on how the horizon problem shapes conditional accounting conservatism.
Cultural influence in the ethical decision making process: The perspective of Malaysian managers

This research explores the influence of culture, measured by the two dimensions of GLOBE’s study (InGroup Organization and Power Distance), in the ethical decision-making process. It also examines the relationship among components of the process. A sample of 236 managers from Malaysian large organizations was collected, and Partial Least Square based on Structural Equation Modeling technique was used to test the expected relationships. Results confirm the influence of in-group collectivism on the ethical decision-making process, but power distance was found to be insignificant. Findings also support that components of the ethical decision-making process follows a sequential process. From a theoretical perspective this study provides valuable insight to evaluate the validity of existing theory as proposed in the literature. From a practical perspective the study provides useful recommendations for organizations to develop policies and programs to encourage ethical behavior. Although this study focuses on Malaysian context, it helps global marketers to increase their knowledge of cultural differences and become more sensitive to them.
Topographic Patterns of Small Subcortical Infarcts Associated with MCA Stenosis: A Diffusion‐Weighted MRI Study

Background and Purpose. Small subcortical infarcts (SSI, maximum lesion diameter ≤2.0 cm) are usually considered as infarcts caused by small vessel disease. However, SSI can also be associated with large artery occlusive disease such as middle cerebral artery (MCA) stenosis. We performed a prospective study to investigate the relationship between MCA stenosis and SSI distribution and further to investigate the mechanism of SSI caused by MCA stenosis. Methods. Magnetic resonance angiography (MRA) and diffusion‐weighed MRI (DWI) of consecutive acute ischemic stroke patients with recent SSI were studied. The distribution of acute infarcts on DWI was categorized as cortical infarct (CI), border zone infarct (BI), or perforating artery infarct (PAI). Results. Totally, 93 cases were recruited, among which 12 had single SSI with MCA stenosis (group 1) and 26 patients had multiple SSI with MCA stenosis (group 2), while 55 patients without MCA stenosis had single SSI (group 3). For patients with single SSI and MCA stenosis, 6 had BI and 6 had PAI; for patients with multiple SSI and MCA stenosis, 25 had BI, 4 had PAI and 9 had CI (compared with group1: P= .001); for patients with single SSI but without MCA stenosis, 20 had BI and 35 had PAI (compared with group1: P= .58). Conclusion. Multiple acute infarcts along the border zone are the commonest pattern in small infarcts with MCA stenosis, especially among those with multiple acute infarcts. Our data suggest that hemodynamic compromise and artery‐to‐artery embolism may be both important factors for infarcts in patients with MCA stenosis.
Mechanical Implantation of Urothelium Into Periureteral Soft Tissue: A Series of 4 Cases Mimicking High-stage Urothelial Carcinoma

In the upper genitourinary tract of the ureter and renal pelvis, any invasion of urothelial carcinoma (UC) beyond the thin muscularis is considered pT3 disease, which may prompt adjuvant chemotherapy. Ureteroscopy is commonly used in the workup of these lesions to obtain tissue biopsies and cytology specimens, or to place stents for the relief of obstructive symptoms. The current study describes 4 cases in which the presence of small nests of urothelium in periureteral and peripelvic soft tissue was noted after ureteroscopic instrumentation, mimicking high-stage UC. All 4 cases had a history of ureteral instrumentation with biopsy of the suspected UC. The diagnostic biopsies showed low-grade noninvasive papillary UC (n=2), papillary urothelial neoplasm of uncertain malignant potential (n=1), and benign inverted urothelial papilloma (n=1). In the definitive resection specimens, small nests of bland urothelium were present in the periureteral or peripelvic soft tissue, raising the possibility of pT3 UC. We interpreted these displaced small nests to be the result of mechanical implantation occurring during the ureteroscopic procedure on the basis of the finding of associated linear fibrosis, inflammation, hemorrhage, and foreign body giant cells. In the setting of low-grade or benign urothelial neoplasms in the upper urinary tract, caution is warranted when cytologically bland nests of the urothelium are identified beyond the muscularis that could represent mechanically induced implants as opposed to invasive UC extending into peripelvic or periureteral soft tissue.
The Potential Economic Benefits of Education of Migrants in the EU

While international mobility has developed into a major driver of population change in the European Union, people with immigrant background in the Member States continue to be placed in disadvantaged socio-economic positions. The purpose of this report is to provide an overview about the potential economic returns to education of migrants at the aggregate level. It covers the current state of economics research as regards returns in three different areas: economic output and growth, labour markets, and governmental budgets. The potential economic gains constitute a rationale for devoting public resources to the education of migrants, especially to foster human capital development of socio-economically disadvantaged migrants without sufficient resources.
Quantification of the distribution of the marginating granulocyte pool in man.

The kinetics of autologous granulocytes, separated from whole blood and labelled with 111In-tropolonate with continuous maintenance in plasma, have been studied in man, using a gamma camera and computer, with the aim of quantifying the distribution of the marginating granulocyte pool (MGP). We have used 3 approaches: dynamic gamma camera imaging immediately following i.v. injection of labelled cells, comparison of the activity signal from 111In-granulocytes with that from previously injected 111In-labelled red cells and absolute quantification of 111In present in liver, spleen and blood. Deconvolution analysis of the hepatic and peripheral blood time activity curves indicated that hepatic granulocyte transit time was 2.5 +/- SE 0.14 min. By comparison with 111In red cells, hepatic transit time was calculated to be 7.4 +/- SE 0.82 that of red cells, which, assuming an hepatic red cell content of 6% that of the total red cell mass, is equivalent to a transit time of 1.8 min. By comparison with 111In red cells, lung granulocyte transit time as a factor of red cel transit time was 5.4 +/- SE 0.7 at 5 min and 2.5 +/- SE 0.13 at 40 min after granulocyte injection. Using these kinetic data, in combination with previously published values for splenic granulocyte transit time, it was calculated that, 5 min after injection, the MGP accounted for 54% of the total blood granulocyte pool (TBGP), was 90% filled, and was distributed between spleen (19%), liver (26%), lung (33%) and the remainder of the body (22%). At 40 min, the MGP accounted for 60% of the TBGP, had equilibrated with the circulating granulocyte pool (CGP), and was distributed between the spleen, liver, lung and remainder of the body according to the following respective percentages: 35, 25, 10 and 30. The total granulocyte contents of the spleen and liver calculated on the basis of the kinetic data were 21% and 22% respectively and in broad agreement with the values, 34 and 23% respectively, calculated from quantitative scanning. It was concluded that about 70% of the body's MGP was present in the spleen, liver and lung. If the MGP is itself 60% of the TBGP then only about 18% of the TBGP marginates in extra-hepatosplenopulmonary sites.
5-year survival in patients with relapsed or refractory chronic lymphocytic leukemia in a randomized, phase III trial of fludarabine plus cyclophosphamide with or without oblimersen.

PURPOSE A randomized trial of oblimersen plus fludarabine/cyclophosphamide (OBL-FC; n = 120) versus FC (n = 121) was conducted in patients with relapsed/refractory chronic lymphocytic leukemia (CLL). The primary end point was met: the complete response (CR) rate, defined as complete or nodular partial response, was significantly greater with OBL-FC than with FC (17% v 7%; P = .025). Among patients with CR, response duration was significantly longer with OBL-FC than with FC (median not reached; > 36 months v 22 months; P = .03). Maximum benefit with OBL-FC, including a four-fold increase in CR rate and a survival benefit with 3 years of follow-up (hazard ratio, 0.53; P = .05), was observed in patients with fludarabine-sensitive disease. We evaluated long-term survival and poststudy CLL therapy among all randomly assigned patients. METHODS Poststudy CLL treatment information was collected. Patients were observed for survival for up to 5 years from the date of random assignment. RESULTS Poststudy CLL treatment was balanced between arms. Intent-to-treat analysis of 5-year survival showed no significant between-treatment difference (hazard ratio, 0.87; P = .34). Among the greater than 40% of patients with complete or partial remission, a significant 5-year survival benefit was observed with OBL-FC (hazard ratio, 0.60; P = .038). Among patients with fludarabine-sensitive disease who had previously demonstrated maximum benefit with OBL-FC, the previously observed survival benefit improved: a 50% reduction in the risk of death was observed (P = .004). CONCLUSION In relapsed/refractory CLL, OBL combined with FC offers patients who achieve complete or partial remission, as well as those who have fludarabine-sensitive disease, a significant survival benefit.