Miracle-dz/UniFAR-FTUs huggingface dataset:
Unraveling molecular determinants of manual therapy: an approach to integrative therapeutics for the treatment of fibromyalgia and CFS/ME

Application of protocols without parameter standardization and rigorous controls has led manual therapy (MT) and other physiotherapy approaches to controversial outcomes. Thus, there is an urgency to carefully define standard protocols that elevate physiotherapy treatments to rigorous scientific demands. One way this can be achieved is by studying gene expression and additional physiological changes that associate to particular, parameter-controlled, treatments in animal models and translating this knowledge to properly design objective, quantitatively-monitored clinical trials. Here, we propose a Molecular Physiotherapy Approach (MPTA), requiring multidisciplinary teams, to uncover the scientific reasons behind the numerous reports of MT that historically attribute benefits to these treatments. The review focuses in the identification of MT-induced physiological and molecular responses that could be used for the treatment of fibromyalgia (FM) and CFS/ME. The systemic effect associated to mechanical-load responses is considered of particular relevance as it suggests that defined, low-pain areas could be selected for treatments with overall benefits, an aspect that might result essential to treat FM. Additionally, MT can provide muscle conditioning to sedentary patients without demanding strenuous physical effort, detrimental for CFS/ME patients, placing MT as a real option for integrative medicine programs to treat FM and CFS/ME.
Peripheral Retinal Changes Associated withAge-Related Macular Degeneration inthe Age-Related Eye Disease Study 2

Purpose: To compare rates of peripheral retinal changes in Age-Related Eye Disease Study 2 (AREDS2) participants with at least intermediate age-related macular degeneration (AMD) with control subjects without intermediate age-related changes (large drusen). Design: Cross-sectional evaluation of clinic-based patients enrolled in AREDS2 and a prospective study. Participants: Participants from prospective studies. Methods: The 200 pseudocolor and fundus autofluorescence (FAF) images were captured on the Optos 200 Tx Ultrawide-field device (Optos, Dunfermline, Scotland) by centering on the fovea and then steering superiorly and inferiorly. The montaged images were graded at a reading center with the images divided into 3 zones (zone 1 [posterior pole], zone 2 [midperiphery], and zone 3 [far periphery]) to document the presence of peripheral lesions. Main Outcome Measures: Peripheral retinal lesions: drusen, hypopigmentary/hyperpigmentary changes, reticular pseudodrusen, senile reticular pigmentary changes, cobblestone degeneration, and FAF abnormalities. Results: A total of 484 (951 eyes) AREDS2 participants with AMD (cases) and 89 (163 eyes) controls without AMD had gradable color and FAF images. In zones 2 and 3, neovascularization and geographic atrophy (GA) were present, ranging from 0.4% to 6% in eyes of cases, respectively, and GA was present in 1% of eyes of controls. Drusen were detected in 97%, 78%, and 64% of eyes of cases and 48%, 21%, and 9% of eyes of controls in zones 2 and 3 superior and 3 inferior, respectively (P < 0.001 for all). Peripheral reticular pseudodrusen were seen in 15%. Senile reticular pigmentary change was the predominant peripheral change seen in 48% of cases and 16% of controls in zone 2 (P < 0.001). Nonreticular pigment changes were less frequent in the periphery than in the posterior pole (46% vs. 76%) and negligible in controls. Conclusions: Peripheral retinal changes are more prevalent in eyes with AMD than in control eyes. Drusen are seen in a majority of eyes with AMD in both the mid and far periphery, whereas pigment changes and features of advanced AMD are less frequent. Age-related macular degeneration may be more than a “macular” condition but one that involves the entire retina. Future longitudinal studies of peripheral changes in AMD and their impact on visual function may contribute to understanding AMD pathogenesis. Ophthalmology 2016;-:1e9 Published by Elsevier on behalf of the American Academy of Ophthalmology
Insulin-Like Growth Factor Receptor Signaling in Thyroid Cancers: Clinical Implications and Therapeutic Potential

Human Thyroid Tumors represent a multistage model of epithelial tumorigenesis. Even though a majority of these tumors originate from follicular cells, they exhibit a broad spectrum with different phenotypic characteristics and variable clinical behavior. Our recent studies suggest that numerous growth factors and their receptors may be abnormally overexpressed or constitutively activated in thyroid tumors to influence their biological behavior. In this chapter we review our current understanding of the role of Insulin-like growth factors (IGFs) and their receptors in the pathogenesis of thyroid cancer and how expression of pIGF-IR may be an indicator of their clinical behavior [1]. Mechanistic evidence for direct involvement of IGF-I signaling in metastasis of anaplastic thyroid cancer & on tumor associated angiogenesis [2] is also discussed. Finally, as several small molecular inhibitors of IGF-IR signaling (peptide-based antagonists and monoclonal antibodies) are being tested, we will discuss the potential impact of utilizing IGF-I signaling pathway as a therapeutic target [2, 3] for aggressive thyroid cancers especially in cases where the current therapeutics have failed to show a favorable outcome.
HISTOCOMPATIBILITY AND LIVER TRANSPLANT OUTCOME

An analysis of more than 500 liver transplants has demonstrated that HLA compatibility is associated with diminished allograft survival. Liver transplants with zero mismatches for class I and/or class II HLA antigens have shown significantly lower actuarial survival rates than transplants with one or more mismatches for these loci. In a group of 119 failed liver allografts from pa­ tients undergoing retransplantation, a higher incidence of failure due to rejection correlated with a lower degree of HLA compatibility especially for HLA-DR. In con­ trast, the incidence of liver transplant failures due to primary nonfunction was relatively higher with HLA­ DR compatible transplants. Considering the role of HLA as a restriction element in cellular interactions during the immune response. these findings suggest that HLA compatibility may have a dualistic effect on liver trans­ plant outcome. On one hand, HLA compatibility reduced transplant rejection-and on the other hand, it may enhance other immunological mechanisms leading to al­ lograft dysfunction, particularly in patients at risk of developing recurrent autoimmune diseases or infection. 1 Recipient of a Research Fellowship from the Deutsche Forschungs­
Local electronic signatures of impurity states in graphene

Defects in graphene are of crucial importance for its electronic and magnetic properties. Here impurity effects on the electronic structure of surrounding carbon atoms are considered and the distribution of the local densities of states (LDOS) is calculated. As the full range from near field to the asymptotic regime is covered, our results are directly accessible by scanning tunnelling microscopy (STM). We also include exchange scattering at magnetic impurities and eludicate how strongly spin polarized impurity states arise.
Helicobacter Pylori have positive association in developing peptic ulcers in patients with chronic liver diseases-an experience from Eastern India

H . pylori infection is commonly associated with Peptic Ulcer Disease (PUD). Role of H. pylori in the development of peptic ulcers with Chronic Liver Disease (CLD) is still not clear. The aim of this study is to find out the prevalence of H. pylori infection among the CLD patients and to identify its relationship in development of peptic ulcer among CLD patients. 60 patients were enrolled from Out Patient Department (OPD) of Medical Gastroenterology in a tertiary care hospital, Kolkata. All patients underwent blood tests to evaluate the liver chemistry. To establish the etiology of chronic liver disease, various biochemical parameters were examined. To find presence of peptic ulcer upper gastrointestinal endoscopy, ultrasonography was conducted. For H.pylori infection, Rapid Urease Test (RUT) and serum IgG for H. pylori were conducted. Active peptic ulcers were detected in 15% among study subjects. Among them, 55.5% tested positive for H. pylori where as among non peptic ulcer subjects, 3.9% tested positive for Helicobacter pylori and the difference was statistically significant (p<.001). The prevalence of peptic ulcer according to UGI endoscope was 15% among patients with CLD, found higher than previous studies. The higher statistically significant prevalence of H. pylori infection among CLD patients with peptic ulcer than without peptic ulcer was also supported by different previous studies done in different settings. This study revealed that there was more prevalence of H. pylori infection in peptic ulcers cases among the CLD patients which is statistically significant.
On Harish-Chandra bimodules for rational Cherednik algebras

We study Harish-Chandra bimodules for rational Cherednik algebras $H_{c}(W)$ associated to a complex reflection group $W$ and parameter $c$. Our results allow to partially reduce the study of these to smaller algebras. We use this to classify those pairs of parameters $(c,c')$ for which there exist Harish-Chandra bimodules with full support, and we give a description of the category of all Harish-Chandra bimodules modulo those bimodules with proper support. When $W$ is the symmetric group, we produce an embedding from the category of Harish-Chandra $H_{c}$-bimodules to the category $\cO_{c}$, prove that its image is closed under subquotients, and find the irreducibles in its image. Finally, when $W$ is of cyclotomic type we produce a duality in the category of Harish-Chandra bimodules. We do this in the more general setting of quantized quiver varieties. Our methods are based on localization techniques, the study of partial KZ functors, the action of Namikawa-Weyl groups and restriction functors.
When Overconfident Traders Meet Feedback Traders

In this paper, we develop a model in which overconfident market participants and rational speculators trade against trend-chasers. We show that the growth and the burst of a financial bubble stem from positive feedback trading. However, the presence of overconfident traders and the risk aversion of the informed speculators enhance the strength of bubbles (creation and burst). The positive feedback trading enhances the negative serial correlation of prices and the volatility of prices. We show that positive feedback traders destabilize prices more than their overconfident opponents. Generally, overconfidence increases the volatility of prices and worsens the market efficiency. But, we show that in the presence of positive feedback trading, overconfidence improves the market efficiency and dampens the excess volatility. When negative feedback traders are present most of the comparative statics are reversed. We obtain that negative feedback traders can earn positive expected profit when their number is low enough.
PERSONAL INITIATIVE : AN ACTIVE PERFORMANCE CONCEPT FOR WORK IN THE 21 st CENTURY

This article reports on the development of a concept of personal initiative (PI). Personal initiative is a work behavior defined as self-starting and proactive that overcomes barriers to achieve a goal. It is argued that future workplaces will require people to show more PI than before, and that current concepts of performance and organizational behavior are more reactive than desirable. The facets of PI are developed along the lines of goals, information collection, plans, and feedback. Personal initiative enables people to deal with job di’culties more actively, for example, with stressors, unemployment, career changes, or becoming an entrepreneur High PI changes the work situation of employees and relates to success as an entrepreneur Personal initiative is seen to sharpen and partly modify the concepts of reciprocal determinism, organizational citizenship behavior innovation, entrepreneurship, work per$ormance, intrinsic motivation, and self-regulation. Research in Organizational Behavior, Volume 23, pages 133487. Copyright
Biomarkers and Coronary Atherosclerotic Burden and Activity as Assessed by Coronary Angiography and Intra-Coronary Imaging Modalities

Coronary artery disease (CAD) is one of the leading causes of death worldwide and it is expected that the rate of CAD will accelerate in the next decade due to overall aging of population and increases in the prevalence of cardiovascular risk factors (type 2 diabetes, obesity, metabolic syndrome) in younger generations (Amborsioni et al., 2003). The mortality associated with atherosclerotic disease is mainly related to the acute coronary syndromes (ACS), including acute myocardial infarction (AMI), unstable angina (UA) pectoris and sudden cardiac death. Inflammation plays a central role throughout the entire disease progression, and it lies at the root of atherosclerosis initiation, progression and its complications (Bonow et al., 2002). However, recent data support the notion that plaques within the coronary circulation become “more severe” or at “high-risk” (vulnerable plaque) in response to a wide array of local and systemic influences, both inflammatory and non-inflammatory (Alsheikh-Ali et al., 2010; Finn AV et al., 2010). Indeed, plaques may have similar structural features and morphologic assessment, but may differ in their biology, their activity, and thus their likelihood of advancing toward clinical complications. Advances in the understanding of the pathogenesis of coronary atheroslcerosis have stimulated development of novel biomarkers, and expanded their role in the different spectra of their underlying pathophysiology (Hochholzer et al., 2010). In this regard, an emerging approach is represented by the assessment of plaque burden, morphology, and remodeling with in vivo atherosclerosis imaging and its correlation to novel biomarkers (Prati & Zimarino, 2010). In the past, invasive coronary angiography (CAG) has been the only diagnostic procedure for identifying coronary atherosclerosis. However, newer intracoronary imaging modalities have been developed allowing a more accurate and precise evaluation of coronary atherosclerotic lesions, with regard to specific morphologic criteria, especially concerning vulnerability. Intravascular ultrasound (IVUS) is a catheter-based technology that allows for assessment of vessel wall thickness and structure while coronary angioscopy also allows to visualize the vessel lumen (Kaneda et al., 2010). More recently, optical coherence
Multiple scales analysis of water hammer attenuation

A multiple scales analysis is used to construct a uniformly accurate approximation to water hammer pressure wave attenuation that is initiated by a sudden valve opening. The method of analysis is well suited to the study of a water hammer that possesses several time scales and is applied to a mild generalization of the classical equations. It should prove useful for finding attenuation curves when effects such as unsteady friction and fluid-structure interaction are added. The analytical results are numerically verified using the method of characteristics.
Lightweight conductive graphene/thermoplastic polyurethane foams with ultrahigh compressibility for piezoresistive sensing

Lightweight conductive porous graphene/thermoplastic polyurethane (TPU) foams with ultrahigh compressibility were successfully fabricated by using the thermal induced phase separation (TISP) technique. The density and porosity of the foams were calculated to be about 0.11 g cm−3 and 90% owing to the porous structure. Compared with pure TPU foams, the addition of graphene could effectively increase the thickness of the cell wall and hinder the formation of small holes, leading to a robust porous structure with excellent compression property. Meanwhile, the cell walls with small holes and a dendritic structure were observed due to the flexibility of graphene, endowing the foam with special positive piezoresistive behaviors and peculiar response patterns with a deflection point during the cyclic compression. This could effectively enhance the identifiability of external compression strain when used as piezoresistive sensors. In addition, larger compression sensitivity was achieved at a higher compression rate. Due to high porosity and good elasticity of TPU, the conductive foams demonstrated good compressibility and stable piezoresistive sensing signals at a strain of up to 90%. During the cyclic piezoresistive sensing test under different compression strains, the conductive foam exhibited good recoverability and reproducibility after the stabilization of cyclic loading. All these suggest that the fabricated conductive foam possesses great potential to be used as lightweight, flexible, highly sensitive, and stable piezoresistive sensors.
Interleukin-1β Induction of NFκB Is Partially Regulated by H2O2-mediated Activation of NFκB-inducing Kinase*

Reactive oxygen species (ROS) have been demonstrated to act as second messengers in a number of signal transduction pathways, including NFκB. However, the mechanism(s) by which ROS regulate NFκB remain unclear and controversial. In the present report, we describe a mechanism whereby interleukin-1β (IL-1β) stimulation of NFκB is partially regulated by H2O2-mediated activation of NIK and subsequent NIK-mediated phosphorylation of IKKα. IL-1β induced H2O2 production in MCF-7 cells and clearance of this ROS through the expression of GPx-1 reduced NFκB transcriptional activation by inhibiting NIK-mediated phosphorylation of IKKα. Although IKKα and IKKβ were both involved in IL-1β-mediated activation of NFκB, only the IKKα-dependent component was modulated by changes in H2O2 levels. Interestingly, in vitro reconstitution experiments demonstrated that NIK was activated by a very narrow range of H2O2 (1–10 μm), whereas higher concentrations (100 μm to 1 mm) inhibited NIK activity. Treatment of cells with the general Ser/Thr phosphatase inhibitor (okadaic acid) lead to activation of NFκB and enhanced NIK activity as a IKKα kinase, suggesting that ROS may directly regulate NIK through the inhibition of phosphatases. Recruitment of NIK to TRAF6 following IL-1β stimulation was inhibited by H2O2 clearance and Rac1 siRNA, suggesting that Rac-dependent NADPH oxidase may be a source of ROS required for NIK activation. In summary, our studies have demonstrated that redox regulation of NIK by H2O2 is mechanistically important in IL-1β induction of NFκB activation.
Asking Questions About Behavior: Cognition, Communication, and Questionnaire Construction

Evaluation researchers frequently obtain self-reports of behaviors, asking program participants to report on process and outcome-relevant behaviors. Unfortunately, reporting on one’s behavior poses a difficult cognitive task, and participants’ reports can be profoundly influenced by question wording, format, and context. We review the steps involved in answering a question about one’s behavior and highlight the underlying cognitive and communicative processes. We alert researchers to what can go wrong and provide theoretically grounded recommendations for pilot testing and questionnaire construction.
The Role of Ultrasonographic Monitoring for Hip Joint Changes in Patients with Chronic Renal Failure

Damir Matokovic, Miroslav Haspl, Petar Petric, Sanja Skorvaga,Vlado Drkulec and Goran Santak Department of Orthopaedics, General County Hospital Pozega Special Hospital for Orthopaedics and Traumatology of the Bone and Joint System Akromion, Krapinske Toplice Department of Internal Medicine, General County Hospital Pozega Department of Clinical Biochemistry, General County Hospital Pozega Department of Pediatrics, General County Hospital Pozega Department of Surgery, General County Hospital Pozega Croatia
Anti-Cytosolic 5'-Nucleotidase 1A (cN1A) Positivity in Muscle is Helpful in the Diagnosis of Sporadic Inclusion Body Myositis: A Study of 35 Japanese Patients

Sporadic Inclusion Body Myositis (sIBM) is a refractory myositis developing in the elderly. Recently, anti-cytosolic 5'-nucleotidase 1A (cN1A) antibodies were reported to be present specifically in sIBM. To assess the clinicopathological features and usefulness of anti-cN1A positivity in muscle specimens, we evaluated a group of Japanese patients with sIBM. Among Japanese patients with myositis who underwent a muscle biopsy from 1991 through 2014 in our hospital, we identified cases of sIBM that met the European Neuromuscular Center (ENMC) criteria. We then analyzed clinical course, pathological findings, and treatment response. Of 282 patients with myositis, 35 (12%) were given a diagnosis of sIBM (24 men and 11 women). The median age at onset was 67 ± 7 (55-81) years, and that at diagnosis was 70 ± 7 years. Remarkably, 5 (14%) patients concurrently had hepatitis C virus (HCV) infection and 4 (11%) had heart disease. Pathologically, we found rimmed vacuoles in 32 (91%) patients and anti-cN1A positivity in perinuclear regions and rimmed vacuoles in 31 (89%) patients. Remarkably, anti-cN1A antibody positivity was significantly higher in sIBM than in polymyositis (30%), dermatomyositis (10%), and morphologically normal cases (0%), suggesting its high specificity for sIBM. Twelve (34%) patients received immunosuppressants, 8 (23%) received prednisone, and 5 (14%) received intravenous immunoglobulins (IVIg). Clinical symptoms transiently improved in 5 patients given prednisone and in 4 patients given IVIg, but these treatments failed to be radical therapies. In our study of Japanese patients with sIBM, anti-cN1A antibody positivity in muscle specimens was highly sensitive and specific pathologically. Therefore, the expression of anticN1A antibody may be greatly useful for the diagnosis of sIBM. Although the concurrent presence of HCV infection and heart disease was notable, other epidemiological characteristics were consistent with the results of previous studies.
Growth hormone (GH) initiates many of its growth-promoting actions by binding to GH 37 receptors (GHR) and stimulating the synthesis and secretion of insulin-like growth factor-1 (IGF-

Department of Biological Sciences, North Dakota State University, Fargo, ND 58108, USA 7 8 9 10 11 12 13 14 15 Running Head: Growth hormone signaling 16 17 18 19 20 21 22 23 Address correspondence and send proofs to: 24 Dr. Mark A. Sheridan 25 Department of Biological Sciences 26 North Dakota State University 27 P.O. Box 6050, Dept 2715 28 Fargo, ND 58108-6050 29 Tel: 1-701-231-8110; Fax: 1-701-231-7149 30 E-mail: mark.sheridan@ndsu.edu 31 32 33 34 35 Articles in PresS. Am J Physiol Regul Integr Comp Physiol (April 13, 2011). doi:10.1152/ajpregu.00414. 2010
A Rare Case of Overlapping Syndrome of ANCAAssociated Glomerulonephritis and Systemic Lupus Erythematosus

Introduction: Two very interesting rheumatologic diagnoses include Systemic Lupus Erythematosus (SLE) and Anti-Neutrophil Cytoplasmic Antibody (ANCA)-negative Vasculitis. It is rare to see these two conditions diagnosed in the same patient. This case analyzes the complex interactions between these two disease states. Case: This is the case of a 69 year old female who presented with shortness of breath, hematuria, and renal failure. Lab work was significant for elevated ANA (1:1280), positive double-stranded DNA antibody, normal complement levels and a negative Vasculitis panel. Renal biopsy was consistent with ANCA-associated Vasculitis (AAV). Thus the patient met diagnostic criteria for both SLE and AAV and was treated accordingly. Conclusion: A review of the literature reveals that these typically separate disease entities when diagnosed together may actually represent a completely new, overlapping syndrome. This case is unique in that there have not been any other cases of a simultaneous diagnosis of SLE and ANCA-negative Vasculitis without evidence of lupus nephritis reported in the literature. A deeper understanding of the mechanism driving these rare diseases can lead to improved prognostication and treatment of these conditions.