Miracle-dz/UniFAR-FTUs huggingface dataset:
Reproducibility in the Assessment of HER2 DISH in Breast Cancer

OBJECTIVE: HER2 gene status is an important biological marker that determines both the prognosis and response to Trastuzumab in patients with breast cancers. Although FISH assay has long been used to determine the HER2 gene copy number, DISH is gaining popularity since it can be assessed with a conventional microscope. The DISH test relies on an individual inspection however, so inter-observer variation may be an issue. MATERIALS AND METHODS: In the current study, reproducibility in the assessment of HER2 DISH test was evaluated in 69 breast cancer samples with HER2 IHC score 2+ and 3+. Two independent investigators evaluated the digitallycaptured images of DISH, without the knowledge of HER2 IHC status. RESULTS: The HER2/CEP17 ratio obtained from both observers were highly correlated (Rho = 0.883, p < 0.001). Based on the ASCO 2013 guideline, agreement of both investigators for HER2 gene diagnosis was 92.75 % (ĸ = 0.848). The HER2/CEP17 ratio of the discordant cases ranged from 1.6 (non-amplifi ed HER2) to 2.6 (low level of HER2 gene amplifi cation). CONCLUSION: It is concluded that the DISH method produces good reproducibility between independent observers, and the result also implies that the HER2 gene copy number is fairly homogenous across an individual breast cancer sample.
Temporal Specificity of Training: An Update

Temporal Specificity of Training: An Update Although the diurnal variation of physical and mental performances is widely investigated, to date, few studies have investigated the effect of training at a specific time-of-day on sport performances and/ or competitive outcomes. This intra-daily variation of performances suggest that athletes could be better during competitions at a specific time-of-day than at others moments. Generally, physical performances are better in the afternoon/evening (i.e. ~16:00 to 20:00 h) than in the morning suggesting that athletes are advised to train and to compete later in the day. However, due to some factors, e.g., media program, competitions are scheduled at different timeof- day. Therefore, to achieve the optimal performance during competitions, it is interesting to adjust the time-of-day of training according to the competitions scheduling. In this context, previous studies showed that: (i) regular trainings in the morning hours may reduce the morning-afternoon differences of sport performances and (ii) regular training in the afternoon hours may increase the morning-afternoon differences of sport performances. For practical recommendations, when the time of competition is not known or when competitions are scheduled at different time-of-day (e.g., judo: eliminations combats are scheduled in the morning and finals combats are scheduled in the afternoon), athletes should be advised to train in the morning. However, when the time of the competition is known, athletes should be advised to coincide the training hours with the time-of-day of competitions.
Effects of Perceived Collaboration with Nurses and Physicians on Nursing Performance in Perioperative Nurses

Purpose: The aim of this study was to identify effects of perceived nurse-nurse collaboration and nurse-physician collaboration on nursing performance in perioperative nurses. Methods: A cross-sectional survey was used and data were collected in September 2016. Participants were 186 perioperative nurses from three advanced general hospitals and nine general hospitals. Data were analyzed using descriptive statistics, independent t-test, One-way ANOVA, Scheffé test, Pearson correlation coefficients and hierarchical multiple regression with the SPSS/WIN 23.0 program. Results: The mean scores were for nurse-nurse collaboration, 2.92±0.28 out of 4, for nurse-physician collaboration, 3.29±0.65 out of 5, and for nursing performance, 3.85±0.47 out of 5. There were statistically significant positive correlations among nurse-nurse collaboration, nurse-physician collaboration, and nursing performance. Hierarchical multiple regression analysis revealed that nurse-nurse collaboration explained an additional 29%p of nursing performance. Shared processes, conflict management, and professionalism of nurse-nurse collaboration were statistically significant predictors of nursing performance. The nurse-physician collaboration explained an additional 3%p of nursing performance. Sharing of patient information was a statistically significant predictor of nursing performance. Conclusion: Findings indicate that intervention programs that integrate and strengthen shared processes, conflict management, professionalism, and sharing of patient information are useful to enhance nursing performance.
INVESTIGATION OF GREEN TURTLE (CHELONIA MYDAS) CUTANEOUS FIBROPAPILLOMATOSIS RECURRENCE RATES FOLLOWING DIODE LASER SURGERY

&NA; A pilot study was performed to investigate fibropapillomatosis (FP) recurrence rates after 940 nm‐diode laser surgeries. Fifteen animals had a total of 274 tumors removed by diode laser. Cutaneous FP recurrence rates were evaluated during a period of 1‐year. According to tumor sizes classification, 166 tumors (60.6%) were <1 cm, 67 tumors (24.5%) between 1‐4 cm, 31 tumors (11.3%) >4‐10 cm and 10 tumors (3.6%) >10 cm. Seven animals (46.6%) were lightly afflicted, 4 (26.7%) moderately, and 4 (26.7%) heavily afflicted. Thirteen animals (86.7%) did not present tumor regrowth and 2 (13.3%) presented small tumors after 1‐year.
Correlation between Schizas Score, Degree of Disability, and Neurogenic Claudication in Lumbar Spinal Stenosis

Background : Magnetic Ressonance Imaging (MRI) is one of modality to diagnosed lumbar spinal stenosis (LSS) however there were some mismatch between the degree of canal stenosis to functional score of LSS. There are some methods to measure the degree of canal stenosis, on of them is Schizas Score. To asses functional score of patients with LSS, there are some tools can be used. Oswesstry Disability Index (ODI) and Neurogenic Claudication Outcome Score (NCOS) are questionnaire commonly used in LSS. This study aimed to analyze the correlation between the degree of stenosis grading using Schizas Score to the degree of disability using ODI score and Neurogenic Claudication using NCOS. Subjects and Method : This was an analytic observational study conducted at Prof. Dr. R. Soeharso Orthopaedic Hospital, Surakarta, Central Java. A sample of 35 patients with LSS in were assessed by filling ODI and NCOS questionnaire, then evaluate the lumbar axial MRI to identify the Schizas Score. The data were analyzed by Spearman test. Results : There was a significant correlation between Schizas Score to ODI score and NCOS. Schizas score increased ODI score (r= 0.91; p<0.001). Schizas score decreased NCOS (r= -0.90; p<0.001). Conclusion : Schizas score is correlated with ODI score and NCOS. Keywords: lumbar spinal stenosis, Schizas score, ODI, NCOS Correspondence: Arief Indra Perdana Prasetya. Resident of Orthopaedic and Traumatology Specialist Program, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: absolu­telly­darkknight@gmail.com. Indonesian Journal of Medicine (2019), 4(2): 116-121 https://doi.org/10.26911/theijmed.2019. 04.02. 05
Fallen idols, broken noses: Defacement and memory after the Reformation

The Henrician and Edwardian Reformations of the 1530s and 1540s were marked by successive waves of iconoclasm in English churches and cathedrals. Statues, screens, wall paintings, and windows were among the idols targeted. While some objects and artworks were destroyed or effaced entirely, others remained in situ, bearing the marks of iconoclastic violence. Even today, many English cathedrals harbour numerous examples of defaced images which have suffered beheading or scoring of the face and hands, but have been neither repaired nor removed. This article explores how various post-Reformation observers including Protestants, Catholics, antiquaries, and poets understood and responded to defaced images, arguing that traditionalists and reformers found a paradoxical common cause in the curation of iconoclasm.
Therapeutic Na+ channel blockers beneficial for pain syndromes

A variety of drugs are used to prevent or treat pain and many of them are known to inhibit the activity of the voltage‐gated sodium channels (VGSCs) required for neuronal excitability. In this overview, we consider the current status and future prospects for these drugs used in two contexts: local application for acute and prolonged blockade of impulses in peripheral nerve, and systemic administration for the relief of chronic pain of metabolic, neuropathic, or cancer origin. Drug Dev. Res. 54:154–158, 2002. © 2002 Wiley‐Liss, Inc.
The writing performance of elementary students using a digital writing application

Purpose This paper aims to investigate elementary students’ writing experiences using a digital writing application and compares the results to the findings and recommendations of a national survey on instructional practices in writing. Design/methodology/approach Mixed methods were used to assess the quantity and quality of P-5 public school students’ writing over time. Teacher, librarian and student perceptions and experiences were examined and compared to the results and recommendations from a national survey on writing. Findings This paper provides empirical insights into the use of a digital writing application in writing instruction. Findings showed the use of a digital writing application: significantly increased the quantity and improved the quality of student writing; excited and motivated students to write; extended the learning day so more time was spent on writing; and supported students of special populations. Comparison to the recommendations of the national survey showed five of seven recommendations were not met in this study. Research limitations/implications Because of the chosen research approach, the research results may lack generalizability. Therefore, researchers are encouraged to conduct further investigations. Practical implications The paper includes implications for writing instruction using digital applications for teachers, librarians and educators in pre-service teacher and school librarian preparation programs. Originality/value Considering limited growth in national writing scores and the transition to online writing assessments by 2019, this paper addresses the need to integrate technology into writing instruction and offers practical strategies for doing so.
A Descriptive Analysis of Performance Models’ Intonation in a Recorded Excerpt from Suzuki Violin School Volume I

Given the importance of modeling in teaching young students to perform, particularly in the Suzuki approach, as well as the importance of playing in-tune, we studied intonation performances on four recordings of Suzuki Violin School Volume I. These are performances that many string teachers recommend as models for beginning string students. We also asked whether performances conform to a theoretical tuning system such as equal temperament (ET) or Pythagorean tuning. We analyzed the first eight measures and the repeat of Minuet I (Bach) in G-major. Individual note deviations of performers ranged from -17 cents to +26 cents relative to the accompaniment, although most deviations were smaller. Overall, three performers tended to be closer to Pythagorean (which is slightly sharper than ET for most major intervals) while one was closer to ET. However, inspection of individual intervals showed that two of the performers were often sharp relative to both tuning systems, particularly for minor seconds and thirds, and major thirds. No performer consistently conformed to either tuning system across the span of notes in the excerpt.
An 8-year review of major congenital abnormalities in a tertiary hospital in Lagos, Nigeria.

Background : Congenital abnormalities are defects present at birth and are increasingly becoming an important cause of neonatal mortality. They can also result in disability in majority of the survivors. Objective : To describe the pattern and outcome of major congenital abnormalities (MCA) in a tertiary hospital in Lagos, Nigeria. Methods : The labour ward and labour ward theatre delivery records and admission records of the in-born ward of the neonatal unit of a tertiary hospital were reviewed retrospectively from January 2007 to December 2014. The MCA were classified according to the 10th revision of the International Statistical Classification of Diseases and Related Health Problems, (ICD-10). Multiple abnormalities were counted once by the system with the most major anomaly. Abnormalities were grouped according to organ systems, sex and yearly distribution. Statistical analysis was based on systemic type, and neonatal outcome. Results : Out of 14581 deliveries during the study period, 167 had MCA, giving an incidence of 11.5 per 1000 total births; 71 (42.5%) were females, 91 (54.5%) were male and 5(3.0%) had indeterminate sex. There was an increase in the yearly incidence from 2007-2014 The most frequent abnormalities were in the central nervous system (31.7%), musculoskeletal system (18.6%), complex congenital abnormalities group (15.5%) and urogenital system (11.4%). Fifty six (31.8%) infants died in the first week of life contributing 12.6% to the overall early neonatal mortality during the study period. Overall case fatality rate was 42.0%; case fatality was highest in the other abnormalities group, followed by chromosomal, cardiovascular and genitourinary system abnormalities respectively. Conclusion : The incidence of MCA in this study is high especially in the central nervous system. There was a steady increase in the yearly incidence during the study period. The overall case fatality rate was also very high with a high contribution to early neonatal deaths Keywords : Congenital abnormalities;Early neonatal death; Lagos;Nigeria; Teratogens.
Performance Enhancement by Memory Reduction

In this paper, we propose a technique to reduce the virtual memory required to store program data. Specifically, we present an optimal algorithm to combine loop shifting, loop fusion and array contraction to reduce the temporary array storage required to execute a collection of loops. Memory reduction is formulated as a net.work How problem, which is solved by the proposed algorithm in polynomial time. When applied to 20 benchmark programs on two platforms, our technique reduces the memory requirement, counting both the data and the code, by 50% on average. The transformed programs gain a speedup of 1.57 on average, due to the reduced working set and, consequently, the improved data locality. In the best case, a maximum speedup of 41.3 is achieved for one of the bencbmark programs.
Assessment of risk factors for cardiovascular diseases among HIV infected patients attending Muhimbili national hospital care and treatment clinic.

Background Mortality due to cardiovascular disease among HIV patients is a concern in both developed and developing countries. The increased cardiovascular events is suspected to be due to the metabolic complications atributed by HIV virus itself and antiretroviral drugs. The CVD risk factors noted to be increased among HIV patients include dyslipidemia, obesity, hypertension, diabetes,excessive alcohol intake and cigarette smoking. But the data is sparse on the magnitude and distribution of these risk factors among HIV patients in Tanzania. Objective This study was aimed at assesing the risk factors for cardiovascular diseases among HIV infected patients attending Muhimbili National Hospital Care and Treatment Clinic. Methods A hospital based cross sectional study was conducted among HIV patients aged 30 years and above attending MNH Care and Treatment Clinic.The study was conducted between August and December 2011.Interviews were done using a structured questionaire followed by a clinical assessment. Fasting blood samples were collected for determination of fasting blood glucose and lipids parameters. Quantitative CVD risk was calculated using Q risk 2011 mathematical model. Results A total of 370 patients were analysed, with 69% being females. The mean age of the study subjets was 40years ( + 8.13) with range of 30-65 years. Seventy four percent of the patients were on HAART. The overall prevalence of dyslipidemia was 82% . The prevalence of hypertriglyceridemia, hypercholesterolemia, incresed LDL and low HDL were 36% ,42%, 53% and 50% respectively.The prevalence of dysglycermia was 16% with prevalence of impared fasting blood glucose and overt DM at 10% and 7% respectively. HAART use was
Methodological Considerations in Data Collection for Language Learning in a Study Abroad Context.

To the extent that study abroad (SA) programs are intended to enhance the language skills of their participants, the design, implementation, and evaluation of them must address the issue of how best one acquires a second language, which in turn entails other questions: What does it mean to acquire a second language? How is the acquisition of another language measured and/or evaluated? How does the SA experience affect it? At least two factors contribute to the fact that these rich data sources are not exploited for answers to these questions more than they are. First, the range of experiences which fall under the rubric of “study abroad” is so varied and complex that generalizations about optimal learning contexts need to be made with great caution. Second, often those best positioned to study this aspect of the SA experience, namely program administrators and teachers, are trained in disciplines which do not prepare them for this task. The purpose of this paper is to outline a series of factors that together provide a framework for looking at SA and to outline some research approaches, methods and techniques appropriate for examining the language acquisition aspects of this experience. A primary benefit of examining analytically the SA experience from a linguistic perspective is internal. They are a common component of many foreign language programs across the country and need to be eval-1
UNSUPERVISED WINDOW EXTRACTION FROM PHOTOGRAMMETRIC POINT CLOUDS WITH THERMAL ATTRIBUTES

Abstract. The automatic extraction of windows from photogrammetric data has achieved increasing attention in recent times. An unsupervised windows extraction approach from photogrammetric point clouds with thermal attributes is proposed in this study. First, point cloud segmentation is conducted by a popular workflow: Multiscale supervoxel generation is applied to the image-based 3D point cloud, followed by region growing and energy optimization using spatial positions and thermal attributes of the raw points. Afterwards, an object-based feature (window index) is extracted using the average thermal attribute and the size of the object. Next, thresholding is applied to extract initial window regions. Finally, several criterions are applied to further refine the extraction results. For practical validation, the approach is evaluated on an art nouveau building row façade located at Dresden, Germany.
The Research on the Motion State Monitoring of Electromagnetic Valve Train of Engine Based on Internet of Things

Aiming at real-time monitoring of valve motion online in a new engine valve train that replaces the traditional cam with a self-developed new electromagnetic linear actuator, this paper presents a system scheme for motion monitoring of the electromagnetic linear actuators based on the Internet of Things and support vector machine (SVM) algorithm, which can effectively monitor the running state of the electromagnetic linear actuator and the valve. The system uses the lower computer to collect the current of electromagnetic linear actuator, and real-time transmits the data to the upper computer in the monitoring center. The upper computer firstly extracts the eigenvector of the motion state of the actuator by wavelet packet decomposition method, and then uses the artificial bee colony algorithm (ABC) to optimize the model kernel function parameters and penalty factor C of support vector machine, and establishes ABC-SVM electromagnetic linear actuator’s motion state model and training. In this paper, the method is compared with the direct-collected wire-controlled detection method. The results show that the system can accurately and quickly monitor and analyze the electromagnetic linear actuator and engine valve operating state, so it is feasible.
Sport, Masculinities and the Body

1. Introduction: Reflexive Approaches to Sport, Masculinities and the Body 2. Sport and Masculinities 3. Bodies and Masculinities 4. 'Expected Masculine Performances' in Mainstream Sports: Serious Competitors, Natural Athletes and Casual Enthusiasts. 5. Young Bodies, Schools and Sport 6. A Lifetime of Sporting Bodily Practices 7. Non-Heterosexual Sporting Bodies 8. Conclusions: Looking at the Bigger Picture. Appendix.
Specific PGF2α receptor (FP) antagonism and human uterine contractility in vitro

Objective PGF2α acts through its receptor, FP, as an important smooth muscle contractile agent. The aim of this study was to investigate the effects of specific FP antagonism, using the novel‐specific FP non‐competitive antagonist THG113.31, on spontaneous and agonist‐elicited contractions in pregnant and non‐pregnant human myometrium in vitro.
Effect of Halothane on Gαi-3 and Its Coupling to the M2 Muscarinic Receptor

Background:Halothane is an effective bronchodilator and inhibits airway smooth muscle contraction in part by inhibiting intracellular signaling pathways activated by the M2 muscarinic receptor and its cognate inhibitory heterotrimeric guanosine-5′-triphosphate (GTP)–binding protein (G protein), Gi. This study hypothesized that halothane inhibits nucleotide exchange at the α isoform-3 subunit of Gi (Gαi-3), but only when regulated by the M2 muscarinic receptor. Methods:GTP hydrolysis by Gαi-3 and the Gαi-3β1γ2HF heterotrimer expressed in Spodoptera frugiperda cells was measured using a phosphohydrolase assay with [γ32Pi]-labeled GTP. Anesthetic binding to Gαi-3 was measured by saturation transfer difference nuclear magnetic resonance spectroscopy. Gαi-3 nucleotide exchange was measured in crude membranes prepared from COS-7 cells transiently coexpressing the M2 muscarinic receptor and Gαi-3. A radioactive analog of GTP, [35S]GTPγS, was used as a reporter for Gαi-3 nucleotide exchange. Results:Although spectroscopy demonstrated halothane binding to Gαi-3, this binding had no effect on [γ32Pi]-labeled GTP hydrolysis by the Gαi-3β1γ2HF heterotrimer expressed in Spodoptera frugiperda cells, nor basal Gαi-3 nucleotide exchange measured in crude membranes when the muscarinic receptor agonist acetylcholine was omitted from the assay. Conversely, halothane caused a concentration-dependent inhibition of Gαi-3 nucleotide exchange with acetylcholine included in the assay. Conclusion:These data indicate that despite halothane binding to Gαi-3, halothane has no direct inhibitory effect on the intrinsic activity of the Gαi-3β1γ2HF heterotrimer but inhibits M2 muscarinic receptor regulation of the heterotrimer. This novel effect is consistent with the ability of halothane to inhibit airway smooth muscle contraction and bronchoconstriction induced by acetylcholine.
Complexity Of Scattering On A Ring Of Processors

In this paper, we prove that the complexity of scattering in an oriented ring of p processors is (p-1) * (p + L * z) where L is the length of the messages, p the communication startup, and z the elemental propagation time. 1. SCATTERING In a recent paper, Saad and Schultz [SSI study various basic communication kernels in parallel architectures. They point out that interprocessor communication is often one of the main obstacles to increasing performance of parallel algorithms for multiprocessors. They consider the following data exchange operations: (1) One-to-one: moving data from one processor to another.