Miracle-dz/UniFAR-FTUs huggingface dataset:
Sarcocephalus latifolius (Sm.) Bruce : études botanique, chimique et pharmacologique

Sarcocephalus latifolius (Sm.) Bruce ou « le pecher africain » est un arbuste de la famille des Rubiaceae poussant principalement dans les regions d'Afrique tropicale subsaharienne. Cet arbuste est connu depuis longtemps en Afrique par les tradipraticiens locaux qui l'administre a leurs patients pour diverses pathologies telles que les infections, la diarrhee, le paludisme, la bilharziose ou encore les douleurs. Les differents organes de cette plante contiennent de nombreux metabolites secondaires tels que des alcaloides, des flavonoides ou encore des tanins responsables des proprietes therapeutiques de cet arbuste. Il a ainsi fait l'objet de nombreuses etudes pharmacologiques qui ont montre qu'il presentait une grande diversite d'actions pharmacologiques : anti-oxydante, hypotensive, hypoglycemiante, antiinflammatoire, antalgique, etc. C'est justement sur cette derniere activite que cette plante a recemment fait parler d'elle dans les medias francais. En effet, en 2013, une equipe francaise de phytochimie s'interessant a l'usage traditionnel de la plante contre les douleurs, a eu la surprise d'isoler a partir des ecorces de racines, un antalgique d'action centrale bien connu et produit par synthese et utilise en therapeutique depuis longtemps, le tramadol. Ainsi, sans le savoir, l'homme avait synthetise un medicament qui existait en realite deja dans la nature. Ce genre de decouverte etait jusqu'a present quasi inedite. Cependant, en 2014, une autre equipe cette fois-ci d'origine allemande, a refait l'experimentation de son cote et a conteste l'origine naturelle du tramadol retrouve dans les racines de S. latifolius. La question de l'origine de ce tramadol effectivement retrouve dans cet arbuste reste donc en suspens en l'attente de nouvelles investigations. Ce memoire permet donc de faire une synthese des connaissances sur l'espece du point de vue botanique, chimique, pharmacologique ainsi que sur son utilisation en medecine traditionnelle.
The relationship between stadium sportscapes dimensions, desire to stay and future attendance : sport participation

Leisure and sport services require spectators to spend extended periods of time in the physical surroundings of the service provider. Servicescapes play an important role in determining whether or not spectators are satisfied, which in turn may influence how long they desire to stay in the facility and whether they intend to re-patronise the leisure facility. Research on servicescapes and to a limited extent on sportscapes has sought to establish the importance of cues in service environments. This study is part of a wider study that examined various dimensions of sportscapes using a quantitative approach in establishing the reliability and validity of a sportscapes scale. Seven sportscapes dimensions were established, namely, scoreboard quality, refreshments, facility aesthetics, space allocation, stadium accessibility, seating comfort and stadium cleanliness. The purpose of the study was to examine the relationship of the identified seven sportscapes dimensions on desire to stay in a sport facility and future attendance. Significant positive correlations were found between the seven sportscape dimensions; desire to stay within a facility and future attendance. The regression analysis reported significant predictive relationships between the stadium sportscapes and desire to stay within the stadia and future attendance. With increasing competition among various sport industries, managers and owners of stadiums need to take cognisance of sportscapes which shape spectators' experience in service provider's environments.
Tailor the adjuvant hormonal manipulation for premenopausal breast cancer patients

The 2016 publication titled “The hormonal manipulation 5-Fluoro-uracil Epirubicin Cyclophosphamide (HMFEC) trial” in the European Journal of Cancer provided an opportunity to revisit the adjuvant HM of premenopausal breast cancer (BC) patients (1). In the HMFEC study, premenopausal BC patients with positive lymph node involvement were randomized in a 2×2 factorial fashion to groups either administered FE50C vs . FE75C followed by HM or no HM. Gonadotrophin-releasing hormone agonists (GnRHa) were used for HM if patients retained menstrual cycle after chemotherapy; for patients became amenorrhea after chemotherapy, tamoxifen was administered. As expected, HM benefit was not seen in ER-negative population. In the ER-positive/ER-unknown subpopulation, the HM provided modest and nonsignificant recurrence reduction [hazard ratio (HR) 0.85, 95% confidence interval (CI) 0.62–1.17, P=0.32] (1).
Absolute and age-dependent elevations of serum calcium and phosphate and their products in clinical opiate dependence

Context: Chronic opiate dependence has been linked with premature appearance of many chronic age-related disorders and blood-borne biomarkers of ageing. Objective: To determine if clinical opiate substance use disorder (SUD) was associated with elevations of serum calcium and phosphate and their various products. Methods: Chemical pathology records were traced retrospectively. Results: A total of 1747 SUD patients were compared with 6454 non-SUD (NSUD) patients. The mean (±SD) ages were 32.06 ± 6.64 and 32.13 ± 8.12 years, respectively (p = 0.74). The two groups were 69.5% and 54.6% male (p < 0.000 1). The mean serum calcium levels were 2.40 ± 0.11 and 2.37 ± 0.10 mmol/l (p < 0.000 1). This significant difference was unrelated to albumin levels, and also occurred for phosphate: 1.17 ± 0.22 and 1.15 ± 0.22 (p < 0.000 1). Both the calcium-phosphate product and the calcium-phosphate solubility product were also elevated. These elevations persisted at multiple regression against age in both additive and interactive models with age (most p < 0.000 1). At age 35, the corrected calcium and phosphate were equivalent to a 75.1% and 13.5% age advancement, respectively. Conclusion: Opiate dependence is associated with significant elevations of calcium and phosphate both in absolute terms, and after correction for serum albumin and age. Their product and their solubility product are similarly elevated.
Assessing Fidelity and Use of Core Implementation Components in the Implementation of a Brief Motivational Intervention to Reduce Binge Drinking Among College Students: A Systematic Review of the Literature

Combating excessive rates of binge drinking and alcohol-related harm among college students continues to pose a challenge for public health practitioners and college administrators. While many interventions to decrease binge drinking have proven effective in research settings, these interventions aren't as effective in non-research settings, such as on college campuses, where rates of binge drinking continue to rise. One such intervention, Brief Alcohol Screening and Intervention for College Students (BASICS), has garnered particular attention in both the research realm and among college health promotion professionals. This brief motivational intervention uses a harm reduction approach to decrease binge drinking behaviors and related consequences among college students who drink heavily. Despite extensive research on its efficacy, there have been no published reports documenting the outcome of BASICS when it has been implemented on college campuses. This thesis addressed this gap in the literature by exploring how BASICS has been applied in campus research settings. Specifically, it focuses on the characteristics of the settings and samples, the extent to which the program maintained fidelity to the original evidence-based BASICS program, and the use of seven core implementation components derived from the field of implementation science. These seven components have been identified as crucial processes in the successful uptake of an evidence-based program like BASICS by an organization, such as a university. A systematic review of the literature revealed that higher levels of program fidelity are associated with positive program outcomes. Additionally, the presence of many or all of the seven core implementation components is associated with higher levels of fidelity and statistically and clinically significant decreases in binge drinking and related harms. Finally, this thesis presents suggestions on how BASICS should be implemented in order to effectively reduce alcohol consumption on college campuses.
Prevalence and Localization of Impacted Canine Teeth in Both Jaws Using Panoramic Radiograph in a Selected Iranian Population, Shiraz, 2012

Background: Since there has been no published report on the impact of permanent canines in Shiraz population, this study was conducted to investigate the prevalence and the location of the impacted permanent canines in patients referred to the Department of Radiology of Shiraz Dental School in 2012.Materials and Methods: This was an analytic cross-sectional study on 1012 panoramic radiographs. For localization, the Canine Incisor Index (CII) was employed.Results: A total number of 28 cases presented with at least one impacted canine. The prevalence of impacted canine (2.8%) was reported not differ significantly between the genders (p>0.05). Fifteen of the total of 28 cases could be included in the method of using CII and 6 were located palatally.Conclusion: According to the results of this study, the prevalence of canine impaction in the selected population is estimated to be 2.8%. Sixty percent of the impacted canines that could be located were in buccal area.
MongoDB: The Definitive Guide

How does MongoDB help you manage a huMONGOus amount of data collected through your web application? With this authoritative introduction, you'll learn the many advantages of using document-oriented databases, and discover why MongoDB is a reliable, high-performance system that allows for almost infinite horizontal scalability. Written by engineers from 10gen, the company that develops and supports this open source database, MongoDB: The Definitive Guide provides guidance for database developers, advanced configuration for system administrators, and an overview of the concepts and use cases for other people on your project. Learn how easy it is to handle data as self-contained JSON-style documents, rather than as records in a relational database. Explore ways that document-oriented storage will work for your project Learn how MongoDBs schema-free data model handles documents, collections, and multiple databases Execute basic write operations, and create complex queries to find data with any criteria Use indexes, aggregation tools, and other advanced query techniques Learn about monitoring, security and authentication, backup and repair, and more Set up master-slave and automatic failover replication in MongoDB Use sharding to scale MongoDB horizontally, and learn how it impacts applications Get example applications written in Java, PHP, Python, and Ruby
MATERNAL HYDRATION AND INFANT WEIGHT: A CASE-CONTROL STUDY IN BREASTFEEDING INFANTS DELIVERED BY CESAREAN SECTION

Growing evidence suggests that infants may experience increased weight loss due to maternal medical interventions during labor such as intravenous fluid hydration. When breast fed infants lose > 7% of their birth weight, formula supplementation is often initiated. Formula supplementation is a variable unequivocally associated with shorter breastfeeding duration. Supplementation should not be initiated if the cause of infant weight loss is unrelated to breastfeeding adequacy. The purpose of this study is to examine the impact of intrapartum maternal hydration and regional anesthesia on infant weight. A retrospective, case-control research study was designed. Data was collected from maternal and infant hospital records. A sample of 272 women and their full-term breastfeeding infants delivered by cesarean section were assigned to either a case (> 8% loss) or control ( 8%. Maternal demographic variables were similar between groups. More mothers in the case group had private insurance (p = .03) and less mothers underwent induction of labor (p = .01). Infants in the case group had heavier birth weights (p = .001). On day four, the exclusive breastfeeding rate had dropped to 53% in the case group compared to 80% in the control group. In the case group infant stools were significantly lower on days two to four and there was a trend toward more voids on day one (p = .09). Maternal IV fluid volume and type of anesthesia were not significantly different between groups. Only 69 (25%) of the women received > 3000 ml of IV fluid. An exploratory analysis of 20 infants whose mothers received > 4000 ml showed that 14 (70%) did experience weight loss > 8%. Epidural anesthesia does not appear to impact infant weight compared to spinal anesthesia. The effects of IV fluid on infant weight remain undetermined. Studies need to examine the impact of maternal IV fluid > 3000 ml on infant weight.
Evaluation of Role of Functional Endoscopic Sinus Surgery in Patients of Sinonasal Diseases & Nasal Polyposis

Introduction: Functional Endoscopic Sinus Surgery has opened up a new horizon in the management of chronic sinonasal (allergic & non allergic) diseases & nasal polyposis. Functional Endoscopic sinus surgery (FESS) is now a days a common and excellent method for the treatment of most of the diseases in the area of nose and paranasal sinuses, like chronic rhinosinusitis with and without nasal polyposis. Materials and Method: In this study we have selected 80 patients of chronic sinonasal (allergic & non allergic) diseases & nasal polyposis attending the department of otorhinolaryngology. All the patients were pre-operatively evaluated clinically, radiologically as well as endoscopically. Diagnostic nasal endoscopy revealed various pathological abnormalities in the middle meatus and anterior ethmoid region. Even after complete pre-operative evaluation, initially patients were managed medically according to their symptoms and were observed for 6 weeks. All 80 patients underwent for functional endoscopic sinus surgery, using the Messerklinger’s approach. Result: The overall result reveal that 85.49% patients considered themselves asymptomatic or improved following surgery. No major complication directly related to FESS occurred in this series. The important finding were, osteomeatal complex obstruction seen in 88.75%, polyp in nose in 46.25% of cases. Radiological evaluation done by coronal section (axial & sagital if needed) CT scanning revealed the maxillary sinus most common site of mucosal involvement 76.25%% followed by anterior ethmoid sinus in 53.75% cases. Frontal and sphenoid sinuses were involved in 26.25% and 15% cases respectively. Conclusion: FESS is highly effective in controlling symptoms of chronic sinonasal diseases with or without polyposis.
Interaction between viruses and prokaryotes in the sea

Tijdens drie expedities in de Atlantisch Oceaan en de Middellandse Zee hebben we onderzoek gedaan naar de verscheidenheid in prokaryoten en de link tussen virussen en prokaryoten over de gehele water column tot en met de abyssopelagische zone (dieper dan 4000 m). Aantallen prokaryoten en virussen in de bathypelagische (1000-4000 m) en de abyssopelagische zone waren erg variabel. Dit betekent dat de heterogeniteit van deze organismen hier hetzelfde was als in de epipelagische zone (0-150 m diepte). Ook was de compositie van de gemeenschap bestaande uit bacterien, archeaebacterien en virussen gestratificeerd over diepte. De contributie van lysogene en/of pseudolysogene virussen in vergelijking tot de totale virus productie neemt toe met diepte en in de nabijheid van meer oligotrofe gebieden. In vergelijking tot de epipelagische zone die gekarakteriseerd wordt door hoge temperaturen and ultraviolette straling kunnen lage temperaturen en dus lager verval in de abyssopelagische zone de oorzaak zijn van de aanhoudende aanwezigheid van infecterende virussen. Concluderend, de resultaten van dit proefschrift laten zien dat in de diepe en donkere oceaan er een hogere dynamiek in virus-gast verhoudingen is dan eerder werd aangenomen en dat deze verhoudingen veranderen ten gevolge van veranderingen in biotische en abiotische variabelen. Verder laten resultaten van een studie uitgevoerd in Arctische kust gebieden zien dat er duidelijke verschillen zijn tussen het actieve gedeelte en de bulk van de bacteriele gemeenschap. Tegenstellingen binnen deze virale en bacteriele gemeenschappen kunnen uitgelegd worden door de invloed van verschillen in UV straling en/of verschillen in de hoeveelheid deeltjes afkomstig van het land op de virale en bacteriele productie.
Mixed silage with Chinese cabbage waste enhances antioxidant ability by increasing ascorbate and aldarate metabolism through rumen Prevotellaceae UCG-004 in Hu sheep

Silage is rich in nutrients, which can make up for the lack of seasonal roughage, and has a certain promotion effect on the intensive feeding of ruminants. In addition, silage can maintain the rumen function of ruminants to a certain extent and reduce the risk of rumen acidosis and abomasum translocation. The purpose of this study was to investigate the effects of the mixed silage of Chinese cabbage waste and rice straw (mixed silage) on antioxidant performance, rumen microbial population, and fermentation metabolism of Hu sheep. The 16 healthy Hu sheep (eight rams and eight ewes, 39.11 ± 1.16 kg, 5.5 months) were randomly divided into two groups (the control group and the mixed silage group) with eight animals (four rams and four ewes) in each group. The control group was fed with farm roughage (peanut seedlings, corn husk, and high grain shell) as forage, and the mixed silage group was fed with the mixed silage as forage. The results showed that the mixed silage had no effect on the growth performance of Hu sheep (p > 0.05). Ruminal butyric acid, total volatile fatty acids (TVFA), and ammonia nitrogen (NH3-N) concentration in the mixed silage group were increased, whereas the pH was decreased (p < 0.05). The blood and rumen total antioxidants capacity (T-AOC) concentration in the mixed silage group was higher, and the malondialdehyde (MDA) content in rumen, serum, liver, and kidney was lower than that in the control group (p < 0.05). PCoA and ANOSIM results of Illumina sequencing indicated that the mixed silage affected the bacterial composition of the rumen microbes. The mixed silage increased the proportion of Prevotellaceae UCG-004 which was in a positive correlation with Vitamin C (Vc). In addition, PICRUSt functional prediction analysis showed that ascorbate and aldarate metabolism were up-regulated in the mixed silage group (p < 0.05). In conclusion, higher contents of VC and acid detergent fiber (ADF) in the mixed silage were beneficial to the growth and reproduction of Prevotellaceae UCG-004, resulting in increased production of the butyric acid significantly upregulated the metabolism of ascorbate and aldarate metabolism, thereby improving the antioxidant properties of Hu sheep.
Effectiveness of closed system manual breast pump versus hand expression on breast engorgement among postnatal mothers admitted in postnatal ward at Government Rajaji Hospital, Madurai

Title: “Effectiveness of closed system Manual Breast pump versus Hand expression on breast engorgement among postnatal mothers”. Objectives: To assess the level of breast engorgement. To evaluate the effectiveness of closed system Manual Breast pump for group-I and Hand expression to group-II on breast engorgement. To compare the effectiveness of closed system Manual Breast pump and Hand expression. To associate the level of breast engorgement score with selected demographical variables. Hypothesis: There is a significant difference between pre and post-test level of breast engorgement. There is a significant difference in post-test level of breast engorgement. There is a significant association in level of breast engorgement among post-natal mothers with their selected socio-demographic variables. Methodology: The conceptual frame work based on modified J.W. Kennys open system Model. Quantitative approach- true experimental comparative research design was adopted. The study was conducted in postnatal ward at Government Rajaji Hospital, Madurai. 60 samples selected by simple random sampling technique. Intervention: Closed system Manual Breast pump for group-1 and Hand expression for group-II. The level of breast engorgement was assessed by 6 point Lactation Consultant scale and Storr scale. Results: Pretest and posttest difference of breast engorgement and pain score in group-I was 28.3%, 32%. In group-II, 38.3%, 40%. The obtained “t” value for group-1 was 6.29 at p= 0.01 level of significant, and for group-II “t”= 10.78 at p=0.001 level of significant. Conclusion: statistical evidence proved that Hand expression of breast milk is more effective than closed system Manual Breast pump in reducing the breast engorgement.
‘No other sign or note than the very order’Francis Willughby, John Ray and the importance of collecting pictures

Describes the collection (Nottingham University Library, MS Mi LM 24) of paintings, drawings, and prints of birds and fishes amassed by two founder-members of the Royal Society and used as a source of illustrations for their publications Ornithologiae libri tres (1676) and De historia piscium libri quartuor (1686). Examines the motivations behind the collection, its arrangement, function, and use, and what this suggests about how natural historians valued pictures and their epistemological significance, especially as signifiers of the structural coherence of nature.
Implementing the reimbursement scheme - views of health and social care staff in six high performing sites

The Community Care (Delayed Discharges) Act 2003 announced a new reimbursement scheme which was intended to accelerate the downward trend in rates of delayed discharges and strengthen joint working between acute health trusts and social services. Under the new scheme hospitals and social services were to agree new inter-agency discharge planning protocols and communication systems, and to operate new legal notification systems that required hospitals to give social services formal notification at least 3 days in advance of a patient’s planned discharge. Agencies were required to agree the numbers of delays each agency was responsible for each week, and acute trusts could charge local authorities for any delays for which they were responsible. Critics warned that the scheme was unsuited to the task, and that its implementation might put partnership working and patient care at risk. This paper explores health and social care staff views on the early working of the reimbursement scheme taken from a broader study of the factors associated with low rates of delays in six sites where performance (in terms of rates of delayed discharge) was exceptionally good. Forty-three qualitative interviews were undertaken between June 2004 and March 2005 with a range of health and social care professionals responsible for, or involved in, discharge arrangements in the six sites. For the majority of staff, the scheme has largely supported joint working; it provided substantial new funding to social services departments for joint commissioning, it has required joint implementation of new interagency notification systems, and close monitoring and interagency communication around delays. Whilst those working with new notification systems have experienced some difficulties with reaching a shared understanding of what is required, the notification system appears to have supported clear and timely communication around discharge between ward and social services staff. Impacts on patients were not clear cut, but there were concerns from some social services staff that, as a result of reimbursement, there was greater likelihood of ‘hurried’ discharges. This paper offers important insights into the early working of the scheme in sites where agencies were already performing well in terms of delayed discharges. It should be of interest to those involved in implementing the reimbursement scheme or with a role in discharge arrangements.