Miracle-dz/UniFAR-FTUs huggingface dataset:
Electrophysiological correlates of memory-based visual change detection in humans

In the oddball condition a frequently presented stimulus (standard) is occasionally replaced by a different stimulus (deviant) when at least in the auditory modality mismatch negativity (MMN) response is elicited to the deviant one. The aim of this study was to clarify if there is visual counterpart to auditory MMN, and if so what kind of a stimulus is able to elicit it. Event-related potentials (ERPs) were recorded from the human scalp from midline electrodes while the subjects listened to a story and concentrated to an auditory task. Three stimulus conditions, the oddball-condition, a deviant-alone condition and a condition in which standard and deviant stimuli were shown equally often, were presented in random order in the experiments. Two different kinds of stimulus pairs were used in this study, one of which stimulated the retina specifically (chessboard figure) and the other universally (color light). The visual counterpart to auditory MMN was not found in this study while early positive-going memory based response was elicited in both experiments in the oddball condition. This response did not emerge in the deviant-alone condition, in which standards were removed from the series. Thus, according this study the visual modality detects changes automatically very early but the mechanism may be different from the auditory modality.
Advice Provided in British Community Pharmacies: What People Want and What They Get

Objectives: This study explored advice-giving behaviour in community pharmacies in order to understand the nature and process of pharmaceutical consultations and consumers' views of the advice-giving role. Method: An ethnographic research strategy was used, combining patient interviews with non-participant observation of interactions between consumers and pharmacy staff. One week was spent in each of 10 pharmacies. Results: The study demonstrated that the advice given in a community pharmacy is almost wholly focused on product recommendation and use. Advice-giving varies according to whether consultations concern prescription or non-prescription medicines. When the latter are involved, advice-giving is mostly consumer-led. Consumers' major ‘need’ for pharmacy services appears to be for information about the effectiveness of products they buy, whilst pharmacists and pharmacy assistants concentrate on providing advice on the safety of medicines. Conclusion: The notion of pharmacists as general health advisors does not appear to be shared by the public and may be at odds with how the public view and use pharmacies. Protocols to guide staff may be improved by including the consumer perspective. Most consumers have previous experience of their ailments and use pharmacies as one of several resources available to them to treat their minor illness, having made their own diagnosis and assessment before entering the pharmacy. The scope for giving new advice is therefore limited. The broader role of community pharmacies merits further attention.
Face Concerns in Interpersonal Conflict

This study sought to test the underlying assumption of the face-negotiation theory that face is an explanatory mechanism for culture’s influence on conflict behavior. A questionnaire was administered to 768 participants in 4 national cultures (China, Germany, Japan, and the United States) asking them to describe interpersonal conflict. The major findings of this study are as follows: (a) cultural individualism-collectivism had direct and indirect effects on conflict styles, (b) independent self-construal related positively with self-face and interdependent self-construal related positively with other-face, (c) self-face related positively with dominating conflict styles and other-face related positively with avoiding and integrating styles, and (d) face accounted for all of the total variance explained (100% of 19% total explained) in dominating, most of the total variance explained in integrating (70% of 20% total explained), and some of the total variance explained in avoiding (38% of 21% total explained) when considering face concerns, cultural individualismcollectivism, and self-construals.
What Affects Facing Direction in Human Facial Profile Drawing? A Meta-Analytic Inquiry

Two meta-analyses were conducted to examine two potential sources of spatial orientation biases in human profile drawings by brain-intact individuals. The first examined profile facing direction as function of hand used to draw. The second examined profile facing direction in relation to directional scanning biases related to reading/writing habits. Results of the first meta-analysis, based on 27 study samples with 4171 participants, showed that leftward facing of profiles (from the viewer's perspective) was significantly associated with using the right hand to draw. The reading/writing direction meta-analysis, based on 10 study samples with 1552 participants, suggested a modest relationship between leftward profile facing and primary use of a left-to-right reading/writing direction. These findings suggest that biomechanical and cultural factors jointly influence hand movement preferences and in turn the direction of facing of human profile drawings.
Infectious tolerance and the long‐term acceptance of transplanted tissue

Summary: Short courses of antibody treatment aimed at blocking the coreceptors CD4 and CD8 and/or costimulatory molecules such as CD40L are able to bring about long‐term acceptance and tolerance of allogeneic transplants. This tolerant state is operational, in that potential effector cells remain but are tightly regulated through the induction of antigen‐specific CD4+ regulatory T cells (Tregs). CD4+CD25+FoxP3+ Tregs appear to play a prominent role, although other categories of Tregs have been documented. Transforming growth factor β (TGFβ) has been found to play a major role in the induction of the tolerant state with therapeutic antibodies as well as promoting the induction of FoxP3+ T cells from naïve populations. The observation that Tregs can be found in tolerated grafts has led to the idea that they may interact with the grafted tissue to establish a state of acquired privilege symmetrical with a similar privileged microenvironment around antigen‐presenting cells in lymphoid tissues. Dampening of aggressive immune responses by Tregs allows antigen to persist and be presented in an innocuous way to promote tolerance in new cohorts of T cells throughout the life of the tolerated graft. Regulation may operate at many stages of an immune response, even as a censor at the terminal differentiation stages of effector function.
Method for analyzing complex two‐dimensional forms: Elliptical Fourier functions

A generalized procedure, elliptical Fourier analysis, for accurately characterizing the shape of complex morphological forms of the type commonly encountered in the biological sciences, is described. Elliptical Fourier functions are derived as a parametric formulation from conventional Fourier analysis, i.e., as a pair of equations that are functions of a third variable. The use of elliptical Fourier functions circumvents three restrictions that have limited conventional Fourier analysis to certain classes of shapes. These restrictions are (1) equal divisions over the interval or period; (2) dependency on the coordinate system, i.e., conventional Fourier functions are not “coordinate free”; and (3) the presence of shapes with outlines that curve back on themselves, a common occurrence. These three limitations are effectively removed with the utilization of elliptical Fourier functions, facilitating the analysis of a much larger class of two‐dimensional forms.
The Normative Nature of Depression Among Impoverished Mothers of Color: “. . .going around this big old circle . . . it always remain the same”

Perinatal depression among impoverished mothers adds an enormous burden to their family responsibilities, which are often further stressed by living in high-crime communities. Thirty impoverished mothers of color living with depression were interviewed about the difficulties they face raising their children. Qualitative interviews about living with depression revealed four themes: recognizing their own depression, feeling isolated, experiencing violence, and living with depression. This article examines how neighborhood and relationship violence, intermittently involved fathers, and isolation contribute to the mothers’ depression. Social workers working with depressed, low-income mothers of color can benefit from understanding the mothers’ lived experience and the barriers the mothers face while trying to achieve well-being for themselves and their children. This study fits within the “Close the Health Gap” area of the Grand Challenges for Social Work.
Cognitive-behavioural therapy v. social activity therapy for people with psychosis and a history of violence: randomised controlled trial.

BACKGROUND Aggression and violence are serious problems in schizophrenia. Cognitive-behavioural therapy (CBT) has been shown to be an effective treatment for psychosis although there have been no studies to date evaluating the impact of CBT for people with psychosis and a history of violence. AIMS To investigate the effectiveness of CBT on violence, anger, psychosis and risk outcomes with people who had a diagnosis of schizophrenia and a history of violence. METHOD This was a single-blind randomised controlled trial of CBT v. social activity therapy (SAT) with a primary outcome of violence and secondary outcomes of anger, symptoms, functioning and risk. Outcomes were evaluated by masked assessors at 6 and 12 months (trial registration: NRR NO50087441). RESULTS Significant benefits were shown for CBT compared with control over the intervention and follow-up period on violence, delusions and risk management. CONCLUSIONS Cognitive-behavioural therapy targeted at psychosis and anger may be an effective treatment for reducing the occurrence of violence and further investigation of its benefits is warranted.
Clinical assessment compared with breathalyser readings in the ER: concordance of ICD-10 Y90 and Y91 codes

Clinical assessment of the amount of alcohol that has been consumed by a patient presenting to the emergency department is notoriously difficult. How should the caring professions respond to the “Epidemic of Binge Drinking in the United Kingdom (UK)”? 1 Alcohol is a drug like any other, which depresses inhibitions initially, but is legal and used by 90% of society, including the medical profession.2 This paper, a work from twelve countries, defines the accuracy of clinical assessment (ICD-10 Y91) by comparison with alcohol breathalyser readings (ICD-10 Y90). It is well worked, multinational, with robust methodologies supported by the World Health …
Pitch, consonance, and harmony.

Comparison of recent psychoacoustic data on consonance with those on roughness reveals that “psychoacoustic consonance” merely corresponds to the absence of roughness and is only slightly and indirectly correlated with musical intervals. Thus, psychoacoustic consonance cannot be considered as the basis of the sense of musical intervals. The basis of that sense seems to be provided by the concept of virtual pitch. This concept is introduced with a model. The concept accounts for many psychoacoustic and musical phenomena as, e.g., the ambiguity of pitch of complex tones, the “residue,” the pitch of inharmonic signals, the dominance of certain harmonics, pitch shifts, the sense for musical intervals, octave periodicity, octave enlargement, “stretching” of musical scales, and the “tonal meaning” of chords in music.
Intensive care unit versus non–intensive care unit postoperative management of head and neck free flaps: Comparative effectiveness and cost comparisons

Despite its widespread use, there is no consensus on the postoperative management in patients undergoing free flap reconstructions. We report the largest study comparing flap outcomes, morbidity, and cost in patients with head and neck cancer free flaps who recovered in the intensive care unit (ICU) versus a “specialty floor” setting.
Structure and stability of the C‐terminal helical bundle of the E. coli mechanosensitive channel of large conductance

The crystal structure of the cytoplasmic domain (CTD) from the mechanosensitive channel of large conductance (MscL) in E. coli has been determined at 1.45 Å resolution. This domain forms a pentameric coiled coil similar to that observed in the structure of MscL from M. tuberculosis and also found in the cartilage oligomeric matrix protein (COMPcc). It contains canonical hydrophobic and atypical ionic interactions compared to previously characterized coiled coil structures. Thermodynamic analysis indicates that while the free EcMscL‐CTD is less stable than other coiled coils, it is likely to remain folded in context of the full‐length channel.
Heartwood extract of Acacia catechu induces apoptosis in human breast carcinoma by altering bax/bcl-2 ratio

Background: The heartwood extract of A. catechu, called pale catechu or “Katha” in Hindi has been widely used in traditional Indian medicinal system. Although various pharmacological properties of this plant had been reported previously, only a few were concerned with the anticancer activity of this plant. Objective: The objective was to assess the in vitro anticancer and apoptosis inducing effect of 70% methanolic extract of “Katha” (ACME) on human breast adenocarcinoma cell line (MCF-7). Materials and Methods: MCF-7 cell line was treated with increasing concentrations of ACME and cell viability was calculated. Flow cytometric methods were used to confirm the apoptosis promoting role of ACME. Morphological changes were then analysed using confocal microscopy. Western blotting was then performed to investigate the expression of apoptogenic proteins and to analyse the activation of caspases. Results: ACME showed significant cytotoxicity to MCF-7 cells with an IC50 value of 288.85 ± 25.79 μg/ml. Flow cytometric analysis and morphological studies confirmed that ACME is able to induce apoptosis in MCF-7 cells. Furthermore, immunoblot results suggested the pathway of apoptosis induction by increasing Bax/Bcl-2 ratio which results in the activation of caspase-cascade and ultimately leads to the cleavage of Poly adeno ribose polymerase (PARP). Conclusion: These results provide the evidence that ACME is able to inhibit the proliferation of MCF-7 cells by inducing apoptosis through intrinsic pathway.
Game-Theoretic Analysis for Power Allocation in Frequency-Selective Unlicensed Bands

Power allocation is an important issue for spectrum sharing of unlicensed bands, in which multiple unlicensed systems may coexist and operate. Recently some works have been reported on game theoretical analysis for multiple systems cooperating in frequency-flat unlicensed bands. However, there has not been much work on the cooperative and competitive strategic behavior of multiple mutually interfering systems in frequency-selective unlicensed bands. In this paper, we construct a game theoretical framework for multiple selfish systems on frequency-selective Interference Channels (IC). This framework enables us to utilize existing protocols designed for frequency-flat ICs in frequency-selective scenarios and can be regarded as an extension of previous results for frequency-flat scenarios.
A model based on oscillatory threshold and build-up of a developmental substance explains gating of adult emergence in Drosophila melanogaster

SUMMARY Adult emergence (eclosion) of fruit flies Drosophila melanogaster under constant laboratory conditions follows a circadian pattern with bouts of eclosion recurring at approximately 24 h intervals. Under periodic light:dark (LD) cycles, adults emerge only during a specific time of the day followed by little or no emergence for the rest of the day. This phenomenon is therefore equated to a gate of emergence that, when open, allows adults to emerge and when closed, no emergence takes place. In this study, we attempt to understand the mechanism underlying adult emergence rhythm in D. melanogaster using a model based on interplay between developmental and circadian clock systems. The model is composed of an oscillatory threshold of a substance that builds up during pre-adult development. Computer simulations based on this model enabled us to make specific predictions about the ‘gate width’ of the adult emergence rhythm under conditions of fast/slow pre-adult development and short/long circadian periods, which we subsequently tested empirically. The main predictions from the simulations are: (1) flies with faster development have greater gate width and vice versa, and (2) flies with faster circadian clocks have shorter gate width and vice versa. To empirically validate these predictions, we carried out experiments on D. melanogaster populations known to have fast/slow pre-adult development, short/long circadian periods and narrow/wide gate width. Additionally, we manipulated the rate of pre-adult development of the above flies by increasing/decreasing ambient temperature to further examine the influence of developmental rates on gate width of adult emergence rhythm by a complementary approach. The results show that gate width is greatly influenced by the duration of pre-adult development and the length of circadian cycles. This suggests that the adult emergence rhythm of D. melanogaster may be based on mechanisms involving oscillatory threshold and build-up of a developmental substance.
Multiresistant Shigella species from African AIDS patients: antibacterial resistance patterns and application of the E-test for determination of minimum inhibitory concentration.

The antibacterial resistance pattern and minimum inhibitory concentrations (MIC) of 25 Shigella flexneri, 5 S. boydii, 8 S. sonnei, and 3 strains of S. dysenteriae type 2 isolated from Kenyan prostitutes with bacillary dysentery and AIDS were determined, and the applicability of the E-test for MIC determination evaluated. All strains were resistant to > or = 3 of 9 different antibacterial agents tested. All strains were resistant to tetracycline and erythromycin, 95% to trimethoprim/sulfonamide, 93% to streptomycin, 54% to ampicillin, 39% to chloramphenicol, 2% to nalidixic acid and none to gentamicin and ciprofloxacin. Six different resistance patterns were observed. The most common pattern was resistance to tetracycline, erythromycin, trimethoprim/sulfa and streptomycin (39%). The E-test was shown to be well-suited for susceptibility testing of multiresistant Shigella spp. ; the reproducibility was excellent and the correlation with the microtiter dilution method and the disk diffusion method were 98% in both instances. The MIC measured with E-test and the microdilution method were within +/- 1 dilution step for 94.4% of the combinations tested.
Bifidobacterium animalis subsp. lactis BB-12 in reducing the risk of infections in infancy

The impact of controlled administration of Bifidobacterium animalis subsp. lactis BB-12 (BB-12) on the risk of acute infectious diseases was studied in healthy newborn infants. In this double-blind, placebo-controlled study, 109 newborn 1-month-old infants were assigned randomly to a probiotic group receiving a BB-12-containing tablet (n 55) or to a control group receiving a control tablet (n 54). Test tablets were administered to the infants twice a day (daily dose of BB-12 10 billion colony-forming units) from the age of 1–2 months to 8 months with a novel slow-release pacifier or a spoon. Breastfeeding habits, pacifier use, dietary habits, medications and all signs and symptoms of acute infections were registered. At the age of 8 months, faecal samples were collected for BB-12 determination (quantitative PCR method). The baseline characteristics of the two groups were similar, as was the duration of exclusive breastfeeding. BB-12 was recovered (detection limit log 5) in the faeces of 62 % of the infants receiving the BB-12 tablet. The daily duration of pacifier sucking was not associated with the occurrence of acute otitis media. No significant differences between the groups were observed in reported gastrointestinal symptoms, otitis media or use of antibiotics. However, the infants receiving BB-12 were reported to have experienced fewer respiratory infections (65 v. 94 %; risk ratio 0·69; 95 % CI 0·53, 0·89; P = 0·014) than the control infants. Controlled administration of BB-12 in early childhood may reduce respiratory infections.
Ovarian Follicle Apoptosis in Bovine Growth Hormone Transgenic Mice1

Abstract Growth hormone directly or via insulin like-growth factor-I has been shown to inhibit preovulatory follicle apoptosis, which is the underlying mechanism of follicular atresia. We studied the levels of apoptosis in the ovaries of transgenic mice expressing bovine growth hormone. Female bovine growth hormone transgenic mice (n = 10) and nontransgenic litter mates (n = 8) were killed at early proestrus. Ovaries were collected, sectioned, and processed using a nonradioactive in situ method for apoptosis detection. Follicles were classified and counted on the basis of size and level of apoptosis. Our results demonstrate that the percentage of ovarian follicles containing apoptotic cells was lower in transgenic versus normal mice (30% vs. 46%; P < 0.05). The percentage of follicles undergoing heavy apoptosis was lower (P < 0.05) in transgenic versus control animals in preovulatory and early antral follicles, but it was not different in preantral follicles. The percentage of healthy preovulatory follicles was also higher in transgenic versus normal mice (7.4% vs. 4.3%; P < 0.05). These results indicate that growth hormone overexpression in transgenic mice significantly decreases follicle apoptosis, and thus atresia in the mouse ovary, therefore leading to increased propensity for ovulation in these animals.