Miracle-dz/UniFAR-FTUs huggingface dataset:
NEW YOUNG STAR CANDIDATES IN THE TAURUS–AURIGA REGION AS SELECTED FROM THE WIDE-FIELD INFRARED SURVEY EXPLORER

The Taurus Molecular Cloud subtends a large solid angle on the sky, in excess of 250 deg2. The search for legitimate Taurus members to date has been limited by sky coverage as well as the challenge of distinguishing members from field interlopers. The Wide-field Infrared Survey Explorer has recently observed the entire sky, and we take advantage of the opportunity to search for young stellar object (YSO) candidate Taurus members from a ∼260 deg2 region designed to encompass previously identified Taurus members. We use near- and mid-infrared colors to select objects with apparent infrared excesses and incorporate other catalogs of ancillary data to present a list of rediscovered Taurus YSOs with infrared excesses (taken to be due to circumstellar disks), a list of rejected YSO candidates (largely galaxies), and a list of 94 surviving candidate new YSO-like Taurus members. There is likely to be contamination lingering in this candidate list, and follow-up spectra are warranted.
Reducing the Impact of Ethnic Tensions on Economic Growth – Economic or Political Institutions ?

We use a standard growth regression model and show that ethnic tensions reduce per capita growth rates. We also find evidence that “good” economic and political institutions improve per capita growth rates. More importantly, good economic institutions mitigate the effect of ethnic tensions on per capita growth while good political institutions do not. Consequently, it is foremost capitalist freedom that promotes peace and development. JEL Classification Codes
Treatment of elderly institutionalized bipolar patients with clozapine.

In an open trial, clozapine was used to treat 3 elderly (mean age 72 +/- 2.5 years) institutionalized male patients with bipolar I disorder, most recent episode manic, severe with psychotic features. All patients were refractory or intolerant of treatment with lithium, valproate, benzodiazepines, and traditional neuroleptics both alone and in combination. Response to clozapine was determined using the Severity of Illness score on the Clinical Global Impression (CGI) scale (1 = normal, not at all ill, 7 = among the most extremely ill). Pre-clozapine severity of illness scores on the CGI averaged 6.33 +/- 0.6; post-clozapine CGI scores averaged 2.0 +/- 1.0 (t = 13.00, df = 2, p < .01). The therapeutic dosage of clozapine varied (range = 25-112.5 mg/day). There were no significant drops in granulocyte counts. Followup revealed sustained improvement over an average of 11 months. These dramatic results suggest that clozapine may be an effective alternative treatment for similar patients and that prospective trials are warranted.
Job satisfaction and organizational commitment for nurses.

OBJECTIVE The purpose of this study is to find out the extent to which nurses in public hospitals are satisfied with their jobs and committed to their hospitals. Also, it is intended to assess the relationship between job satisfaction and organizational commitment, as well as to examine the effect of nurses' demographic factors on these 2 variables. METHODS Two-hundred and ninety nurses working in a number of public hospitals are the sample size. The measures of the study are already tested for validity and reliability. In this study, they are also examined and found to be valid and reliable. The method of data collection used was the questionnaire to include a large sample. RESULTS The means and standard deviations show that nurses are satisfied with their jobs to some extent, and they are slightly committed to their hospitals. A strong positive correlation between job satisfaction and organizational commitment was found at 0.59 (p <.01). Also, age is significantly correlated with satisfaction and commitment, but experience is correlated only with the latter. Moreover, analysis of variance shows that nurses differ in their degree of commitment in terms of their marital status and nationality, whereas they differ in their degree of satisfaction only with regard to their nationality. CONCLUSION This study found that nurses in public hospitals are slightly satisfied and committed to their hospitals. Besides, satisfied nurses tend to have a higher degree of commitment than less satisfied ones. However, further research is needed to examine this result before a generalization is made.
Autoimmune Hepatitis Triggered by Treatment With Pegylated Interferon α-2a and Ribavirin for Chronic Hepatitis C

Hepatitis flare is rarely observed during treatment with pegylated interferon alpha for hepatitis C virus (HCV) infection. A 49-year-old man receiving pegylated interferon α-2a for HCV infection had icterus and hyperbiliru-binemia in the 14th week of therapy, with HCV RNA undetectable after the 12th dose. Liver biopsy was suggestive of chronic hepatitis with cirrhosis without interface pattern. Pegylated interferon was discontinued; a few weeks later, his aminotransferases and immunoglobulin levels increased significantly. Antibody to cytosolic liver antigen-1 was positive, and liver biopsy revealed lymphoplasmacytic infiltrate with intense interface hepatitis, consistent with autoimmune hepatitis.
Effects of Soil Moisture and Nickel Contamination on Microbial Respiration Rates in Heavy Metal-Polluted Soils

Soil microorganisms may be both sensitive and resilient to various disturbances. The effects of a single stressor on soil microorganisms have been well studied, but only limited research has been carried out to test the effects of simultaneous action of diverse stressors. Soil samples were collected from a long-term polluted zinc and lead site and an unpolluted site. Modeling studies assumed spiking soils with five different concentrations of nickel (400, 800, 1.600, 3.200, and 6.400 mg Ni·kg -1 dry weight soil) and their incubation under different humidity conditions (10%, 75%, and 120% of water holding capacity). We wanted to test if additional environmental disturbances have a different effect on microorganisms from polluted and unpolluted soils. The study showed that after 30 and 120 days of incubation, increasing Ni pollution inhibited microbial respiration rate (R), both in unpolluted and long-term metal polluted soils, irrespective of soil moisture. After 30 days of the experiment, microbial communities in both soils demonstrated a similar response to the additional toxicant. However, after 120 days of exposure to Ni, microbial communities from the unpolluted soil showed much higher inhibition of R than microbes from the polluted soils (p<0.001). The results might suggest that Ni co-tolerance mechanisms occurred in long-term metal polluted microbial communities.
[Expression of DUOX2 in psoriasis and atopic dermatitis lesion].

OBJECTIVE To investigate the expression of dual oxidase 2 (DUOX2) in psoriasis vulgaris lesions, atopic dermatitis (AD) lesions and normal skin and its role in cutaneous anti-inflammation. METHODS Tissue samples were harvested from psoriasis lesion area, psoriasis non-lesion area, AD lesion area and AD non-lesion area, as well as normal skin, the expression level of DUOX2 protein was detected by immunohistochemical staining. The mRNA level of DUOX2 was detected by reverse transcription polymerase chain reaction (RT-PCR) analysis. RESULTS The expression of DUOX2 protein was observed in all groups which mainly located in basal layer, spinous layer and dermal papilla layer. Compared with the psoriasis non-lesion group and normal skin group, the expression level of DUOX2 protein in psoriasis lesion group was significant higher (P<0. 01). The expression of DUOX2 protein in AD lesion group was stronger than that in AD non-lesion group and normal skin group (P<0. 01). In addition, the expression level of DUOX2 protein in AD lesion group was significant higher than that in psoriasis lesion group (P<0. 01). RT-PCR test revealed DUOX2 mRNA was expressed positively in psoriasis and AD lesions. CONCLUSION The strong expression of DUOX2 in psoriasis vulgaris lesion and AD lesion suggested that DUOX2 may play an important role in the mechanisms of cutaneous anti-inflammation.
A helix-to-coil transition at the ε-cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis

Processing of amyloid precursor protein (APP) by γ-secretase is the last step in the formation of the Aβ peptides associated Alzheimer's disease. Solid-state NMR spectroscopy is used to establish the structural features of the transmembrane (TM) and juxtamembrane (JM) domains of APP that facilitate proteolysis. Using peptides corresponding to the APP TM and JM regions (residues 618–660), we show that the TM domain forms an α-helical homodimer mediated by consecutive GxxxG motifs. We find that the APP TM helix is disrupted at the intracellular membrane boundary near the ε-cleavage site. This helix-to-coil transition is required for γ-secretase processing; mutations that extend the TM α-helix inhibit ε cleavage, leading to a low production of Aβ peptides and an accumulation of the α- and β-C-terminal fragments. Our data support a progressive cleavage mechanism for APP proteolysis that depends on the helix-to-coil transition at the TM-JM boundary and unraveling of the TM α-helix.
Image Charge and Dipole Combination Model for the Schottky Barrier Tuning at the Dopant Segregated Metal/Semiconductor Interface

First-principle-based calculations are given to explain the Schottky barrier height (SBH) modifications of nickel silicide/silicon contacts by dopant atoms. Dopant atoms, including B, Al, In, Mg, P, As, Sb, and S, are placed near the NiSi2/Si interface, and a systematic study of their effects on the band structure is considered. A new image charge and dipole combination model is proposed to explain the SBH tuning by these atoms, which is in good agreement with experimental observations. Both image charge and dipole moment provide the same p-SBH lowering direction for B atom and the same n-SBH lowering direction for Sb atom. Therefore, the total lowering of the SBH is enhanced for B and Sb; thus, they are good candidates for SBH modifications of nickel silicide/silicon contacts in CMOS applications.
Comparative Analysis of the Financial System in Croatia and the Financial Systems in Advanced Transition Economies

The Croatian financial system has entered a new phase of its development. As a result of the important and deep changes that have altered the image of the banking system, the conditions for more dynamic development of non-banking intermediaries and capital markets have been created. In order to assess the achieved level of financial development, the Croatian financial system is compared with the financial systems of advanced transition economies. The analysis is based on the standard indicators of size and activity of banking and non-banking intermediaries as well as of those of capital markets. The results of the analysis show that the size and activity of Croatian banking system is comparable to that of the banking systems of advanced transition economies. However, the achieved level of development of non-banking intermediaries and the capital market is still below that of other advanced transition economies. It is expected that Croatian financial system will fill this gap relatively quickly since activities of pension funds, investment funds and bond markets are growing quickly.
Clinical and prognostic role of annexin A 2 in multiple myeloma

1Medizinische Klinik V, Universitätsklinikum Heidelberg, Heidelberg, Germany; 2Nationales Centrum für Tumorerkrankungen, Heidelberg, Germany; 3Centre Hospitalier Universitaire Montpellier, Institute for Research in Biotherapy, Hôpital Saint-Eloi, Montpellier, France; 4Inserm U1040, Montpellier, France; 5Orthopädische Klinik, Universitätsklinikum Heidelberg, Heidelberg, Germany; 6Klinik und Poliklinik für Unfallchirurgie, Universitätsklinikum Gie en und Marburg GmbH, Justus-Liebig-Universität Gie en, Gie en, Germany; 7Klinik und Poliklinik für Kinder und Jugendmedizin, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; and 8Institut für Humangenetik, Universität Heidelberg, Heidelberg, Germany
Emdros: a text database engine for analyzed or annotated text

Emdros is a text database engine for linguistic analysis or annotation of text. It is appliccable especially in corpus linguistics for storing and retrieving linguistic analyses of text, at any linguistic level. Emdros implements the EMdF text database model and the MQL query language. In this paper, I present both, and give an example of how Emdros can be useful in computational linguistics.
Nicotine depedence and salivary cotinine concentration in daily smokers

There is scant information on nicotine dependence in smokers not seeking cessation treatment. This study analyses the relationship between nicotine dependence, measured by the Fagerström Test for Nicotine Dependence (FTND), and salivary cotinine concentration in a sample of smokers from the general population. We conducted a cross-sectional study (2004–2005) of a representative sample of the general population of Barcelona, Spain (n=1245). The analysis included 196 daily smokers aged more than 16 years. Information on smoking was obtained by questionnaire and cotinine concentration was determined in saliva. Geometric means of cotinine concentration by every single FTND item were computed, and multivariate linear regression was used to explore the relationship among these variables. Participants smoked a mean of 17.0 cigarettes per day, and the mean FTND score was 3.27 (95% confidence interval: 2.92–3.61). Around 17% of subjects (95% confidence interval: 12.0–22.5%) had high nicotine dependence. Cotinine concentration differed significantly by nicotine dependence levels. In a multiple linear regression model including the sum of the FTND items 2, 3, and 6, and the single FTND items 1, 4, and 5, adjusted for sex, the time to first cigarette after waking up (item 1), the number of cigarettes smoked daily (item 4), and smoking more in the first hours of the day (item 5) were significantly related to salivary cotinine concentration (R2=0.414). Salivary cotinine levels were associated with nicotine dependence as measured by the FTND, especially with the items on daily tobacco consumption, time to first cigarette after waking up, and smoking more in the first hours of the day.
VORTEX RINGS PINNING FOR THE GROSS-PITAEVSKII EQUATION IN THREE DIMENSIONAL SPACE

We construct traveling wave solutions possessing multiple stationary vortex rings with neighboring interaction to the problem iût = ε 2 4 û + ( Ṽ − |û| ) û, û ∈ H(R), where the unknown function û is defined as û : R3 ×R→ C, ε is a small positive parameter and Ṽ is a smooth potential. We first consider the case for two rings lying the same plane in a such way that they have interaction in the normal direction, which will be balanced by the role of trap potential. We also construct two parallel vortex rings which are trapped by the potential Ṽ so that they have balance of interaction in the binormal direction.
Vascular‐selective Effect of Lercanidipine and other 1,4‐Dihydropyridines in Isolated Rabbit Tissues

The aim of this study was to characterize the in‐vitro vasoselectivity of lercanidipine (in comparison with lacidipine, amlodipine, nitrendipine and felodipine) by evaluating its functional calcium antagonistic activity on rabbit vascular (aorta) and cardiac tissues (heart ventricle).
Interleukin‐8 production in response to tumor necrosis factor‐alpha by cholesteatoma keratinocytes in cell culture

Keratinocytes harvested from acquired cholesteatoma and grown in cell culture will demonstrate increased interleukin‐8 (IL‐8) production in response to tumor necrosis factor (TNF)‐alpha as compared with a control keratinocyte cell line. Immunohistochemical studies have identified IL‐8 and TNF‐alpha, mediators of bony destruction, in tissue samples of cholesteatoma. TNF‐alpha stimulates IL‐8 production in healthy epidermal keratinocyte cell lines. It is not known whether TNF‐alpha stimulates IL‐8 production in cultured cholesteatoma keratinocytes.
Solitary trichoepithelioma: clinical, dermatoscopic and histopathological findings.

UNLABELLED Trichoepithelioma is part of the adnexal carcinomas. It is a benign, small tumor, usually under a centimeter in diameter, which develops in the basal cells of the hair follicle. CASE REPORT We present the case of a 30-year-old female patient, from rural area, which was hospitalized in the Clinic of Dermatology, Emergency County Hospital, Craiova, Romania, in March 2015, for the presence of a skin tumor, with round-oval shape, 0.5 cm in diameter, brownish colored, located on the left cervical region. The patient had no past medical history. The skin tumor appeared two years ago, and it was slowly increasing in size. Physical examination was in normal ranges. The dermatoscopic examination reveal a pearly white background covered with tumor islands that were oval shaped, with hyperpigmentation, centered by keratin cysts and surrounded by collagen. During hospitalization, we performed tumor biopsy. The histopathological examination showed microscopic structure of trichoepithelioma. After history taking, physical examination, dermatoscopic examination and histopathological result, our diagnosis was left cervical trichoepithelioma. CONCLUSIONS Trichoepithelioma is a rare trichogenic tumor, which appears at any age, including newborns, with potential for local recurrence. Our case report represents a classic dermatoscopic aspect of trichoepithelioma, that can have close resemblance to basal cell carcinoma and other skin adnexal tumors, clinically, dermatoscopic and histopathological.
Aging is associated with hypermethylation of autophagy genes in macrophages

ABSTRACT Autophagy is a biological process characterized by self-digestion and involves induction of autophagosome formation, leading to degradation of autophagic cargo. Aging is associated with the reduction of autophagy activity leading to neurodegenerative disorders, chronic inflammation, and susceptibility to infection; however, the underlying mechanism is unclear. DNA methylation by DNA methyltransferases reduces the expression of corresponding genes. Since macrophages are major players in inflammation and defense against infection we determined the differences in methylation of autophagy genes in macrophages derived from young and aged mice. We found that promoter regions of Atg5 and LC3B are hypermethylated in macrophages from aged mice and this is accompanied by low gene expression. Treatment of aged mice and their derived macrophages with methyltransferase inhibitor (2)-epigallocatechin-3-gallate (EGCG) or specific DNA methyltransferase 2 (DNMT2) siRNA restored the expression of Atg5 and LC3 in vivo and in vitro. Our study builds a foundation for the development of novel therapeutics aimed to improve autophagy in the elderly population and suggests a role for DNMT2 in DNA methylation activities.
Altered Frontal and Temporal Brain Function during Olfactory Stimulation in Adult Attention-Deficit/Hyperactivity Disorder

Objective: Olfactory processing depends on dopamine metabolism and orbitofrontal cortex functioning, both known to be disturbed in attention-deficit/hyperactivity disorder (ADHD). Some investigations suggested alterations in olfactory processing (identification and sensitivity) in childhood and adult ADHD. Methods: In the present study we investigated olfactory function (Sniffin’ Sticks) of 29 adult patients with ADHD (17 combined, 11 inattentive, and 1 hyperactive/impulsive subtype) and 29 controls matched for sex, handedness, age, intelligence, and education. Additionally, we measured frontal, temporal, and somatosensory cortical activity during olfactory perception. This was performed with functional near-infrared spectroscopy (fNIRS) during presentation of 2-phenylethanol (olfactory stimulant) and linalool (mixed olfactory/trigeminal stimulant) in two concentrations each. Results: Adult patients with ADHD and controls did not differ in sensitivity for and discrimination and identification of olfactory stimuli. Functional brain imaging measures with fNIRS generally revealed diminished activation in olfaction-associated brain regions in patients with ADHD. Only for a high concentration of linalool, oxygenated haemoglobin (O2Hb) concentrations in patients were similar to controls (significant increase in the temporal, somatosensory, and inferior-frontal cortex). O2Hb concentrations in active brain regions positively correlated with ADHD symptoms during childhood and trait impulsivity. These effects were carried for the subgroup with combined subtype. Conclusions: Although we could not replicate altered clinical performance in ADHD, our fNIRS findings suggest an association of cortical olfactory processing with hyperactivity and impulsivity in adult ADHD.
Knowledge of alpha-1 antitrypsin deficiency among internal medicine house officers and respiratory therapists: results of a survey.

BACKGROUND Alpha-1 antitrypsin deficiency is a common genetic condition that predisposes to emphysema and liver disease. Alpha-1 antitrypsin deficiency is under-recognized, so affected individuals often experience long delays in diagnosis and visits to multiple physicians before correct diagnosis. Reasoning that inadequate knowledge about alpha-1 antitrypsin deficiency could contribute to this under-recognition, we designed this study to evaluate internal medicine house officers' and respiratory therapists' (RTs) knowledge of alpha-1 antitrypsin deficiency. METHODS We evaluated knowledge of alpha-1 antitrypsin deficiency with a Web-based test containing 30 multiple-choice questions. Invitations to take the test were sent via e-mail to all internal medicine house officers and RTs at The Cleveland Clinic main campus hospital. We assessed test scores by profession, years of training/experience, and self-assessed knowledge of alpha-1 antitrypsin deficiency. RESULTS Of 332 invitees, 202 (61%) responded, of whom 165 (50%) provided complete responses (99 RTs, 66 physicians). The mean scores (percent of correct answers) were 54% and 52% for physicians and RTs, respectively (P = .25). The scores did not differ among the physicians when examined by subspecialty (pulmonary/critical care vs other) or post-graduate education level (P = .94). RTs who had graduated from a 4-year respiratory therapy program had a higher mean score than those who had graduated from a 2-year program (56% vs 50%, P = .02). Respondents' whose self-assessment of their knowledge about alpha-1 antitrypsin deficiency was "somewhat knowledgeable" had higher test scores than any other self-assessed knowledge level, regardless of profession. CONCLUSIONS These results indicate a generally low level of knowledge about alpha-1 antitrypsin deficiency among physicians and RTs. Causes of under-recognition of alpha-1 antitrypsin deficiency, including the possibility of poor knowledge as a contributor, warrant further study.