Miracle-dz/UniFAR-FTUs huggingface dataset:
HARNESSING VIRTUAL TEAM PERFORMANCE BY MANAGING CONFLICT

This paper reports on a qualitative case study on conflict management in virtual ten the software industry of South Africa. Virtual teams are common in the software industry, a main contributor to wealth creation. Failure is common, with conflict cited as a contributing factor. A purposive sample was selected, while data were collected through an electronic questionnaire and analyzed by means of content analysis. Empirical evidence suggested that conflict, with positive and negative consequences was managed within the team, preventing disharmony and supporting constructive disagreements between members; thus, facilitating team performance and competitiveness This study contributes to the emerging body of knowledge on the effective functioning of virtual teams
Does the Epileptic Side (Left, Right, Bilateral) Differently Impair the Cognitive Functioning in Patients with Benign Childhood Epilepsy with Centro-Temporal Spikes (BECTS)? A Literature Review

In Canada, Epilepsy affects approximately 3 to 6 per 1000 children between the ages of 0 and 15. Of these children, 15-25% suffer from benign epilepsy with centro-temporal spikes (BECTS), making BECTS the most common benign childhood focal epileptic syndrome. Impact of the side of epileptic foci on cognitive development however remains unclear. Among 269 articles from 1806 to 2016 reviewed, 17 articles have specifically addressed the impact of the side of epileptic foci on the cognitive functioning. Our review suggests that the epileptic side is more deleterious to cognitive functions specifically sub served by the same hemisphere. However, for reasons that remain unclear, other cognitive functions may also be affected. We recommend that these children benefit from a neuropsychological follow-up.
Beden Eğitimi Öğretmen Adaylarının Fiziksel Benlik Algıları ve Öğretmenlik Mesleğine Yönelik Tutumlarının Analizi

The purposes of this study were to determine the physical self perceptions of the physical education teacher candidates and their attitudes toward teaching profession on the basis of gender, grade and active participation in sport. Eight hundred and fourteen physical education teacher candidates from six different universities participated in this study. Data concerning physical self perception were collected by using Physical Self-Description Questionnaire (PSDQ). Data concerning attitudes toward profession of teaching were also collected by Attitude Scale Toward Teaching Profession. Analysis demonstrated that candidates at lower levels had attitudes towards teaching profession at a moderate level; and females, lower-year students, and physically active students had higher attitude scores compared to males, upper year students and inactive students. Physical self perceptions of the physically active teacher candidates were higher than the inactive candidates. A significant increase was observed in PSDQ subscales of sports competence and appearance as a result of the progression of the program; but decrease was observed in body fat and global physical self-concept (p<0.05). Additionally, a significant and positive relationship was found especially between the senior teacher candidates’ global physical self-concept (r= .403, p<0.01) and self-esteem (r= .395, p<0.01) and their attitudes towards teaching.
Gastroesophageal Reflux Disease (GERD) in the East—Same as the West

Gastroesophageal reflux disease (GERD) is basically the same disease in the East as in the West. Although it is one of the most common illnesses in Western patients, GERD is still comparatively uncommon in the East. Furthermore, Asian patients with GERD often exhibit milder disease with lower prevalence of complications including Barrett esophagus. Recent data, however, indicate that it is an emerging disease in Asia and its increase in prevalence seem to be a time lag phenomenon when compared with the West. Pathophysiologic factors in Asian patients have been noted to be the same as in Western patients except on a lower magnitude. A lower acid secreting capacity has been reported in Chinese patients and low dietary fat and reduced obesity may account for better gastric emptying and decreased transient lower sphincter relaxations. The high Helicobacter pylori prevalence in the East may also account for lower acid secretion and consequent milder GERD. Heartburn, which is the cardinal symptom of GERD in the West may not be present in Asian patients who may in fact, complain with nonspecific chest discomfort and labeled as having noncardiac chest pains. Extra esophageal manifestations in Asian patients have not been well studied but available data suggest that it is not uncommon. Treatment practices in the East are similar to the West. Proton pump inhibitors are widely prescribed, but its use is often limited by cost as patients are often not insured and are “self paying. ” Surgery and endoscpic therapy for GERD are not commonly carried out.
A Good Death: Conversations with East Londoners

care issues and a wider range of professional concerns. The paper from Jecker and Self, for example, explores the care-cure debate and the relationship between medicine and nursing, but as an attempt to address wider concerns it is insufficient. There is mention in the introduction of the development of caring ethics, but there is no real contribution on this theoretical approach. The book looks impressive and well prcsented, but first impressions give way to some irritation at the presentation of the content. Many of the chaptcrs have simply been photocopied from the original journal and then presented as camera ready copy; some of these copies appear not to have been of the highest quality. Each chapter thus has a different appearance, with different fonts, some in columns and some not. Each page is numbered sequentially throughout the book, but also has the page number of the original journal. The book has a name index, but no subject index, which somewhat detracts from the book's usefulness as a reference work.
Knowledge and attitude toward vasectomy among antenatal clinic attendees in a tertiary health facility in Nigeria

Background: Nigeria is the most populous nation in Africa and has a high fertility rate and low contraceptive prevalence. Various strategies have been developed to reduce the fertility rates, all aimed toward increasing contraceptive prevalence. Male sterilization is a safe, cheap, and effective method of contraception, but female perception and awareness of vasectomy may greatly affect its utilization. Objective: To determine the knowledge and attitude of antenatal patients in a Nigerian tertiary health facility toward vasectomy. Subjects and Methods: A cross-sectional study was conducted among antenatal clinic attendees. The participants were selected via systematic random sampling technique and a structured pretested questionnaire was used to assess their knowledge and attitude toward vasectomy. Data analysis was done using SPSS version 17 statistical software for windows XP and results were expressed in percentages. Results: One hundred and fifty respondents participated in the study, 83 (55.3%) were aware of vasectomy, 59 (71.08%) accepted it as a method of male contraception, and only 23 (38.98%) approved its use for their spouse. The main source of information on vasectomy was from health workers 53 (63.86%). Almost half of the women (47.8%) who accepted vasectomy did so because they felt men should also participate in family planning. Most of the women who disapproved of vasectomy cited it as an unpopular method. Conclusion: The approval of use of vasectomy by female partners is poor. Majority of these patients would not recommend it to their spouse as they have wrong perception of the procedure. Re-education of medical workers and wider public education through mass media may improve the approval of vasectomy by women for their spouses.
Children with disabilities and their families : team working and the role of the key worker

The unique nature of the needs of children with disabilities and the varied dynamics of family life mean that service provision cannot be boxed neatly into the individual arenas of health, education or social care. These children and their families’ present service providers with complex challenges that often test the system. The co-ordination of, and communication between, members of the team around the child often falls to the parent.
Efficacy of the PARP inhibitor (PI) ABT-888 (veliparib [vel]) either with carboplatin (carb) or as a single agent followed by post-progression therapy in combination with carb in patients (pts) with BRCA1- or BRCA2- (BRCA)-associated metastatic breast cancer (MBC).

520 Background: Based on the concept of synthetic lethality combining platinum agents and PIs should benefit patients (pts) with BRCA-associated MBC. We report mature outcomes with vel alone, or with carb. Methods: Pts with germline BRCA-associated MBC, ECOG performance status of ≤ 2, without prior PI treatment were included. In phase I the maximum tolerated dose (MTD) of carb (AUC of 5) IV every 21 days, and vel 150 mg BID were defined. In phase II, pts received vel 400 mg BID and upon progression, carb and vel at the MTD. Results: Between 6/2010 and 4/2014, 72 evaluable pts (28 in phase I, 44 in phase II) with BRCA1 (34 patients) or BRCA2 (37 patients) mutations (1 pt had both) and with MBC were enrolled. The median age was 44-years (range; 28-68); 49% of pts had hormone receptor + MBC. Pts received a median of 1 (0 – 5) prior chemo-regimen for MBC. Response rate (RR) for the 28 pts in phase I was 50% [CR rate 18%] and 2 pts remain in CR at 43+ and 34+ cycles, both are on vel maintenance, alone; median .
Hanging by a thread: Topic development and death in an online discussion of breaking news

This project analyzes messages generated for an online discussion group and the topics of conversation that guide responses and prompt participants to introduce new threads for discussion. Data for this project are more than 300 postings to an unmoderated public electronic discussion group, OKLABOMB, established one day after the April 19, 1995, bombing of a federal building in Oklahoma City. Selected for analysis because it started as a dynamic forum for up-to-minute information, this list within a few days had degenerated away from its original purpose into a forum dominated by a handful of participants posting on marginally-related topics. Ethnographic observation of these messages coupled with conversation analysis focused on topic development revealed (often hostile) strategies used by dominant participants to bring about topic shifts. The results provide one linguistic measure of the ways in which powerful and/or persistent language users control conversation online and challenge the notion that computer-mediated discourse is democratic (cp. Herring, 1993). More generally, the results shed light on how conversational topics come alive and die in a multi-participant online environment.
Reply to T. Komiya et al

Komiya et al raise an important point that many so-called targeted drugs in fact inhibit multiple related proteins. Crizotinib is an effective inhibitor of multiple kinases including mesenchymal-epithelial transition (MET), v-ros avian UR2 sarcoma virus oncogene homolog 1 (ROS1), RON, and anaplastic lymphoma kinase (ALK), and thus one must be careful in asserting the identification of the single important target in individual samples. Extrapolating the preclinical results of single cell lines is even more dangerous; unfortunately, we have been limited to the HCC78 line as the single ROS1-rearranged line currently available. The data we have so far, acknowledging these caveats, indicate that ROS1 rearrangement is the major driver of events in these tumors and the major correlate of crizotinib sensitivity. More than 25 of the patient samples we have identified with ROS1 fusions have been tested for MET gene amplification, and all were negative for MET amplification. This includes more than 10 ROS1-positive patients treated to date on the phase I study of crizotinib. The preliminary response rate (complete or partial responses) to single-agent crizotinib has been 55% to 60% in this population, which is as good as has been observed in ALK-positive patients on crizotinib. In addition, TAE684, which is an effective ALK and ROS1 kinase inhibitor with negligible MET activity (micromolar range IC50) still effectively inhibits HCC78 growth. Interestingly, the HCC78 line seems only moderately sensitive to crizotinib, whereas the responses in patients have been impressive. Other pathway activation, such as MET activation as Komiya et al suggested, may be partially responsible for the relatively poor sensitivity of HCC78 to crizotinib. We know that the activation of other kinases, such as epidermal growth factor receptor (EGFR), can mediate the development of resistance to crizotinib in patients with ALKpositive lung cancer. We also know that MET amplification can mediate resistance to EGFR inhibitors in EGFR-mutant lung cancers. Thus, it would not be surprising that another kinase such as MET could become activated in a subset of ROS1-positive patients who develop resistance to crizotinib. So although the presence of MET protein activation is certainly a possibility in ROS1-rearranged tumors, we find that the presence of ROS1-rearrangement by itself is a strong predictor of crizotinib response and most certainly represents the major driver gene in these tumors.
A study of clinical and hematological profile of children with sickle cell disease in a tertiary care hospital, Valsad, India

Background: Sickle cell disease is commonly seen in rural population of south part of Gujarat in India. It is one of the common causes of recurrent hospitalization, morbidity and mortality in pediatric population. This study was therefore undertaken to evaluate the clinical profile of sickle cell disease in a tertiary care hospital. Methods: This was the prospective observational study done from November 2015 to October 2016. All the hospitalized diagnosed case of sickle cell disease and trait in age group of 6 months to 14 years were taken in this study. Sickle cell disease with some genetic or metabolic disease and sickle-beta-thalassemia patients were not included in this study. Results: Total 61 patients were admitted over a one year of study period, out of which 47 were sickle cell disease and 14 sickle cell trait patients. Morbidity events were commonly observed in 5-12 years of age groups (68.85%). Seasonal variation also observed, 47.54% of total cases are seen in winter season. Pain (60.65%) was the most common presenting symptom. Severe pallor (39.34%) and splenomegaly (24.59%) was the most common sign in both groups. Vaso-occlusive crisis (59.01%) was the most common morbidity event observed, of which abdominal pain was the most common site of pain involvement. On laboratory analysis, there was statistically significant difference observed in disease and trait. In patients with sickle cell disease acute painful crisis (59.57%) was the common morbidity event observed while in sickle cell trait patient’s acute febrile illness (71.42%) observed. Conclusions: Vaso-occlusive crisis is the commonest manifestation in pediatric age group. Comprehensive medical care and management is required to decrease the morbidity and mortality.
The experience of mesothelioma in northern England.

Mesothelioma is a potentially preventable fatal disease causing almost 2000 deaths/year in the UK, increasing in incidence, and lacking effective treatments. ‘The Experience of Mesothelioma in Northern England’ is a community-based, mixed methods, case study in four parts, conducted in Barrow-in-Furness, Leeds and Doncaster. The study investigates the experience of pleural mesothelioma for patients and their families, and for healthcare professionals and service providers. Mesothelioma is experienced as a devastating disease that carries a severe burden in physical, psychological, and social domains. Breathlessness, usually due to recurrent pleural effusions, and/or pain occur in >90% cases and may be refractory. Psychosocial aspects relate to causation, latency, rapid decline in health, helplessness regarding severe symptoms, and impending death. The erratic trajectory is unusual in malignancy. Disease burden is high in terms of multiple invasive investigations and emergency admissions and is reflected in service usage: 2 or 3 hospital admissions, 5 outpatient appointments and 11 GP consultations, 4 of these at home, occurred on average in the last year of life. Median survival was 294 days and 45% died in hospital, 30% in hospice, and 14% at home. Patients tend to react with stoicism and patients (and relatives) adopt a ‘coping narrative’ which may prevent timely access to supportive services. Bereaved relatives’ emotional accounts reflect witnessing severe suffering, express anger and blame around the potentially avoidable asbestos exposure, and present the deaths due to mesothelioma as ‘mass murder’. State benefits and civil compensation procedures, and the Coroner’s investigation, create additional distress. Severe bereavement reactions have features of ‘tragic grief’. In spite of the severe symptom burden, less than half of the patients were referred to palliative care and there was no systematic approach to care and support of either patients or their relatives. The study has implications for research and service provision.
Beyond Models and Decisions: Situating Design through generative functions

This paper aims to situate Design by comparison to scientific modeling and optimal Decision. We introduce " generative functions " characterizing each of these activities. We formulate inputs, outputs and specific conditions of the generative functions corresponding to modeling (G m), Optimization (G o) and Design (G d): G d follows the classic view of modeling as a reduction of observed anomalies in knowledge by assuming the existence of unknown objects that may be observed and described with consistency and completeness. G o is possible when free parameters appear in models. Gd bears on recent Design theory, which shows that design begins with unknown yet not observable objects to which desired properties are assigned and have to be achieved by design. On this basis we establish that: i) modeling is a special case of Design; ii) the definition of design can be extended to the simultaneous generation of objects (as artifacts) and knowledge. Hence, the unity and variety of design can be explained, and we establish Design as a highly general generative function that is central to both science and decision. Such findings have several implications for research and education.
Long-Term Results of Charnley Low Friction Arthroplasty for Ankylosing Spondylitis

The authors determined the long-term results of 95 Charnley low friction arthroplasties performed on 58 patients with ankylosing spondylitis. The average age at the time of operation was 39.7 years (range, 19 - 70 years) and average duration of follow-up was 19 years (range, 10–30 years). All patients had substantial relief of pain, improvement of function, and range of motion of the joint, and 55 patients (95%) were completely free of pain. Twelve acetabular and nine femoral components were revised for aseptic loosening at an average of 13.9 years (range, 4.2 - 20 years) with 79 original femoral components (83%) and 78 acetabular components (82%) remaining in situ. Six femoral and eight acetabular components were radiologically loose and a total of 20 acetabular components (21%) and 15 femoral implants (16%) had loosened aseptically. There was no heterotopic ossification in 71 hips (75%), with 22 hips (23%) having minor changes (Brooker Class I or 2), two hips (2%) having clinically important ossification (Class 3) and none having reankylosis. Survivorship of the acetabular component (with 95% confidence intervals) was 92% at 10 years (87% - 98%), 85% at 15 years (77% - 93%), and 77% at 25 years (67% - 87%). Femoral implant survivorship at the same time intervals was 90% (84% - 96%), 87% (79% - 94%), and 77% (80% - 99%), respectively. Charnley low friction arthroplasty provided good long-term results in this series of young and active patients, without the increased risk of the development of heterotopic ossification and reankylosis that has been reported previously.
Comparative in Vitro Activity of Tobramycin, Gentamicin, Kanamycin, Colistin, Carbenicillin, and Ticarcillin on Clinical Isolates of Pseudomonas aeruginosa: Epidemiological and Therapeutic Implications

: The susceptibility of clinical isolates of Pseudomonas aeruginosa to six antibiotics was related to the epidemiologic knowledge yielded by serotyping. The agar dilution method for determination of minimal inhibitory concentrations (MICs) and the Habs serotyping system were used. Effectiveness of each agent ranked highest to lowest as follows: tobramycin, colistin, ticarcillin, carbenicillin, gentamicin, and kanamycin. For many isolates, the MICs of gentamicin were close to the peak level in serum. Susceptibility to carbenicillin and to ticarcillin were highly correlated, with MICs of ticarcillin half those of carbenicillin. Similary, susceptibility to gentamicin and to tobramycin were correlated. For susceptible strains, MICs of gentamicin were two to four times greater than those of tobramycin. However, strains resistant to gentamicin were clearly in one of two groups: susceptible to tobramycin or resistant to the drug. Most strains resistant to both gentamicin and tobramycin were serotype 11, whereas those resistant gentamicin and kanamycin only were nonagglutinable.
Plasma levels of copper, iron and zinc in healthy primary school children from rural communities of Ebonyi State, South Eastern Nigeria

Plasma copper, iron and zinc were determined in 295 primary school children; mean age = 8.81 ± 2.07 years from rural communities in Ebonyi State, Southeastern Nigeria using atomic absorption spectrophotometers. Copper and zinc deficiencies were found in 4.1% and 6.1% respectively while inadequate plasma iron and anaemia were found in 21.4% and 20%, respectively. Significantly, higher prevalence of zinc deficiency was observed in females (8.8% vs. 3.4%; p = 0.047) and copper deficiency in males (6.1% vs. 2.0%; p = 0.043). Although, plasma copper and zinc decrease with pupils’ age, only copper was found to be statistically significant (r = –0.121, p = 0.038). Data suggest that copper and zinc malnutrition may not be of concern among rural primary school children however, sustenance of functional health facilities and public health education on food diversification and good personal and environmental hygiene are advocated.
The effect of orthographic regularity on children’s handwriting production

Ce travail etudie comment l’irregularite orthographique des mots influence l’organisation graphomotrice de l’ecriture. Des enfants de CP et CE1 ont ecrit des mots reguliers et irreguliers sur une tablette digitalisante. L’irregularite pouvait se trouver en debut, milieu et fin de mots acquis tot et tard. Les resultats montrent que les durees de production etaient plus importantes pour les mots irreguliers que pour les mots reguliers. Toutefois, les differences n’etaient significatives que pour les mots acquis tard. Les mots reguliers et irreguliers acquis tot, seraient donc actives directement du lexique orthographique. Les mots acquis tard seraient traites par application de regles de recodage phonologique. L’ecriture de mots reguliers serait satisfaisante. L’ecriture de mots irreguliers necessiterait la memorisation de l’orthographe du mot entier ainsi que le rappel de l’identite et de la localisation de l’irregularite orthographique. Cette operation constituerait une surcharge cognitive resultant en une augmentation de la duree de production.