Miracle-dz/UniFAR-FTUs huggingface dataset:
Small Diameter Acetabulum and Femoral Head in Total Hip Arthroplasty for Developmental Dysplasia of the Hip, with no Femoral Osteotomy

We present the results of 66 total hip arthroplasties in 62 patients of mean age 46 years (24-74 years), with developmental dysplasia of the hip. In all cases the centre of rotation of the new hip was positioned at the site of the true acetabulum. In all patients cementless press fit acetabular components of small diameter (42-44 mm) were used, articulating exclusively with a 22.25 mm modular metal femoral head, without the use of bone grafts or shortening osteotomies of the femur. Despite the use of small diameter femoral heads the rate of dislocation was 3%. After an average follow-up period of 9 years (4-18 years), no revisions were required for infection, loosening or wear or implant migration. Osteolytic lesions were seen in the periacetabular region in 3 patients who were symptom free. A total of 2 revisions were required for instability and 2 patients had the wires of their trochanteric osteotomy removed because of bursitis. Leg length inequality was improved in 55% of the patients and one postoperative transient sciatic nerve lesion settled within 4 months. We believe that in patients with painful dysplastic hips, the use of small diameter implants with the centre of rotation at the true acetabulum, can give very satisfactory results, without any supplementary procedures.
Effect of nasal antifungal therapy on nasal cell activation markers in chronic rhinosinusitis.

OBJECTIVE To examine the effect of nasal antifungal treatment on eosinophil cationic protein (ECP) and tryptase levels in samples of nasal lavage fluid from patients with chronic rhinosinusitis and nasal polyps. DESIGN Prospective double-blind placebo-controlled clinical trial. SETTING Tertiary surgical center. PATIENTS Subjects with severe chronic rhinosinusitis and nasal polyps. Of 120 screened patients, 76 were eligible. Six patients withdrew because of minor adverse events, and 10 dropped out for other reasons. In total, 60 patients completed the study according to the study protocol. INTERVENTIONS Nasal treatment with amphotericin B or saline control for 8 weeks. MAIN OUTCOME MEASURES Nasal lavages were performed before and after treatment. Fungal elements were assessed by culture and with different polymerase chain reaction assays. Levels of ECP and tryptase were determined by fluorescent enzyme immunoassay. RESULTS No correlation between cell activation markers and fungus detection was observed before treatment (all P>.20). Nasal amphotericin B treatment had no effect on levels of ECP (P = .17) or tryptase (P = .09) in nasal lavage samples. Moreover, successful fungus eradication, defined as fungus detection before but not after treatment, did not influence nasal ECP or tryptase levels (all P>.40). CONCLUSION Neither topical amphotericin B therapy nor fungal state before and after treatment had any significant influence on activation markers of nasal inflammatory cells in chronic rhinosinusitis.
Adding ultrasound in the management of soft tissue disorders of the shoulder: a randomized placebo-controlled trial.

BACKGROUND AND PURPOSE There is still a lack of evidence about the beneficial effects of ultrasound (US) intervention for the management of soft tissue problems. Thus, this study was designed to assess the effectiveness of US over a placebo intervention when added to other physical therapy interventions and exercise in the management of shoulder disorders. SUBJECTS AND METHODS Forty patients who were diagnosed by ultrasonography or magnetic resonance imaging to have a periarticular soft tissue disorder of the shoulder were randomly assigned to either a group that received true US (n=20; mean time since onset of pain=8.7 months, SD=8.8, range=1-36) or a group that received sham US (n=20; mean time since onset of pain=8.1 months, SD=10.8, range=1-42). Besides true or sham US (10 minutes), superficial heat (10 minutes), electrical stimulation (15 minutes), and an exercise program (15-30 minutes) were administered to both groups 5 days each week for 3 weeks. RESULTS Subjects showed within-group improvements in pain, range of motion, Shoulder Disability Questionnaire scores, and Health Assessment Questionnaire scores with the intervention, but the differences did not reach significance when compared between the groups. DISCUSSION AND CONCLUSION The results suggest that true US, compared with sham US, brings no further benefit when applied in addition to other physical therapy interventions in the management of soft tissue disorders of the shoulder.
Reliability practice in Aerospace Zero-defect Systems Engineering Management

The Aerospace Zero-defect Systems Engineering Management (AZDSEM) is the managerial system and methodology currently applied in Chinese aerospace industries. Its key elements are to make ‘doing things right at first time’ as the target and require various tasks to be successfully and reliably implemented; to ensure excellent quality of the products and accurate operation in various R&D, manufacturing and service processes under aerospace projects. This paper provides a comprehensive overview of AZDSEM in a reliability perspective. By summarizing the current practice and analyzing its managerial system structure, elements and analysis method, some suggestions for further improving AZDSEM are proposed in the aspects of developing its corresponding quality strategy, training and audit programs.
Toddlers' transitions on non-verbal false-belief tasks involving a novel location: A constructivist connectionist model

Some argue that children learn a Theory of Mind (ToM), the understanding that others have mental states, at around 3.5 years. This is evidenced by their transition from failure to success on verbal false-belief tasks, when they begin to verbally predict an actress will search for a toy where she falsely believes it to be, rather than in its actual location. However, nonverbal measures have recently been used to show that children in their second year of life may already have some understanding of others' false beliefs. We present a Sibling-Descendant Cascade-Correlation neural-network model of one study that found 25-month-old toddlers correctly anticipated an actress would search according to her false belief. Networks were trained on true- and false-belief search patterns, simulating toddlers' everyday experience with true and false beliefs, and then tested on nonverbal true- and false-belief tasks involving a novel location. Networks transitioned from incorrectly predicting true-belief searches in both true- and false-belief tasks to making correct predictions in both tasks. Our model thus (1) reproduced the transition that has been observed in older children and (2) generalized its learning to a novel location. The model can be used to refine our understanding of the transitions while again demonstrating the usefulness of SDCC as an algorithm for modeling cognitive development.
Patient outreach to promote colorectal cancer screening among patients with an expired order for colonoscopy: a randomized controlled trial.

BACKGROUND Targeted interventions to promote colorectal cancer screening among specific populations could increase screening rates. Patients with an expired order for screening colonoscopy might be persuaded to follow through with screening by such an intervention. METHODS We conducted a randomized controlled trial of a combined reminder/outreach intervention among patients in a large general internal medicine practice. Participants included 628 patients aged 50 to 79 years with an expired order for screening colonoscopy. Patients were stratified based on receipt of any previous colorectal cancer screening and randomly assigned either to (1) an intervention group that received a mailing containing a reminder letter from their primary care physician, a brochure and digital video disc about colorectal cancer and colorectal cancer screening, and a follow-up telephone call or (2) a usual care control group. The primary outcome was receipt of fecal occult blood testing, sigmoidoscopy, or colonoscopy within 3 months of randomization. Screening outcomes were observed for an additional 3 months (6 months from randomization). RESULTS Screening rates at 3 months were 9.9% (31 of 314 patients) in the intervention group and 3.2% (10 of 314 patients) in the control group (rate ratio, 3.1; 95% confidence interval, 1.5-6.2; P = .001). At 6 months, rates were 18.2% (57 of 314 patients) and 12.1% (38 of 314 patients), respectively (rate ratio, 1.5; 95% confidence interval, 1.03-2.2; P = .03). CONCLUSION Patient outreach to individuals with an expired order for colonoscopy may be an effective tool to modestly increase short-term completion of colorectal cancer screening. TRIAL REGISTRATION clinicaltrials.gov Identifier: NCT00793455.
Lower cervical rheumatoid subluxation with tetraplegia.

1. Four patients with tetraplegia from rheumatoid subluxation occurring in the lower cervical spine are described and the common features are noted. 2. Compression appeared to be responsible for the cord damage, although it was not necessarily directly related to vertebral subluxation. The lesions causing the compression were varied. 3. Forcible attempts to reduce vertebral subluxation may be harmful. Two patients were improved by posterior decompression. 4. A suggested programme for the treatment of such patients is outlined.
Perceived Mentoring Relationships and Career Outcomes—Results from the Indian Power Sector

There has been a growing realization among the organizations for nurturing their workforce through mentoring programmes. The role of mentoring has been found to be highly crucial in influencing the employee’s career outcomes. This study examined the impact of perceived mentoring relationships on the career outcomes of career satisfaction and career commitment. The participants consisted of 124 managers from the Indian power sector organizations. Results depicted that in the Indian power sector, managers only perceived psychosocial mentoring support acted as a significant predictor of career outcomes of career satisfaction and career commitment. However, perceived career mentoring was not found to have any significant impact on career outcomes. Overall, this research contributed in mapping the scenario of perceived mentoring relationships from the employee’s perspective and their linkage with career commitment and career satisfaction in the Indian power sector context. Further, discussion on managerial implications and future directions was also provided.
Saccharomyces cerevisiae Porin Pore Forms Complexes with Mitochondrial Outer Membrane Proteins Om14p and Om45p

Background: Currently, no information is available about the association of the mitochondrial porin pore with the major outer membrane proteins Om14p and Om45p. Results: Por1p forms complexes with Om14p and Om45p. Conclusion: Molecular organization of the porin pore and its interaction with the inner membrane is influenced by Om14p and Om45p. Significance: The newly identified protein complex improves the understanding of mitochondrial transport processes. Numerous transport processes occur between the two mitochondrial (mt) membranes due to the diverse functions and metabolic processes of the mt organelle. The metabolite and ion transport through the mt outer membrane (OM) is widely assumed to be mediated by the porin pore, whereas in the mt inner membrane (IM) specific carriers are responsible for transport processes. Here, we provide evidence by means of Blue Native (BN)-PAGE analysis, co-immunoprecipitation, and tandem affinity purification that the two mt OM proteins Om14p and Om45p associate with the porin pore. Porin molecules seem to assemble independently to build the core unit. A subpopulation of these core units interacts with Om14p and Om45p. With preparative tandem affinity purification followed by MS analysis, we could identify interaction partners of this OM complex, which are mainly localized within the mt IM and function as carriers for diverse molecules. We propose a model for the role of the two OM proteins in addressing the porin pore to bind to specific channels in the mt IM to facilitate transport of metabolites.
Integration of computer and Internet-based programmes into psychiatric out-patient care of adolescents with depression

The aim of this explorative study was to describe nurses' opportunities to integrate computer and Internet-based programmes in psychiatric out-patient care among adolescents with depression. Therefore, nurses' daily computer use and possible problems related to it were investigated. The data were collected by conducting focus group interviews with Finnish registered nurses (n = 12) working at the out-patient clinics of two university central hospitals. The data were analysed using inductive content analysis. The analysis showed that nurses used the computer and Internet in their daily work for data transmission and informal interaction with adolescents. Findings revealed that nurses have good computer skills, a positive attitude towards using the computer and Internet and were motivated to make use of both on a daily basis. Problems faced in daily computer use were a lack of instructions and education, and lack of help and support. We can conclude that nurses have good opportunities to implement computer and Internet-based programmes in adolescent out-patient care. These results are encouraging keeping in mind that adolescents are the most active Internet users in society.
Efficacy of skin barrier creams (IV). The repetitive irritation test (RIT) with a set of 4 standard irritants

An improved human model for the quantification of skin barrier creams (BCs) is described. In contrast to the previously published procedure, the back, instead of the forearm, and a total of 4 irritants are used. Due to the larger area, 3 BC formulations can be simultaneously compared to the control field, which receives the irritant only, without BC‐pretreatment. On 10 human volunteers, the irritants 10% sodium lauryl sulfate (SLS), 1% sodium hydroxide (NaOH), 30% lactic acid (LA) and undiluted toluene (TOL) were applied via large Finn Chambers for 30 min, 5 × during the 1st week and 4 × during the 2nd week. Taktosan Salbe (water‐in‐oil emulsion) and RAWI Speerschutzcreme (oil‐in‐water emulsion) were applied 30 min before contact with the irritants. In order to asses reproducibility and interindividual variation, the BC RAWI was tested in duplicate. Irritant cutaneous reactions were quantified by 4 parameters: erythema score, transepidermal water loss, blood flow volume and stratum corneum hydration by measuring capacitance. The results showed marked differences in efficacy. Taktosan significantly suppressed irritation by SLS, NaOH and LA, which was apparent in nearly all parameters. RAWI caused significant inhibition of SLS irritation, and a positive trend against NaOH and LA was observed. Both BCs failed against TOL. The results of duplicate testing with RAWI showed good reproducibility. The dogma that oil‐in‐water emulsions are primarily effective against lipophilic irritants, and water‐in‐oil emulsions against hydrophilic irritants, needs to be re‐evaluated on the basis of our findings. This model seems to have potential for further studies on BCs and might elucidate the complex interaction of BCs with irritants.
Effects of bile reflux and intragastric microflora changes on lesions of remnant gastric mucosa after gastric operation.

AIM To investigate the effects of bile reflux and intragastric microflora changes on lesions of remnant gastric mucosa after gastric operation. METHODS Concentration of bile acid and total bacterial counts (TBC) in gastric juice were measured in 49 patients with peptic ulcer before and after gastrectomy. One year after the operation, sample of gastric mucosa taken from all the patients were used for histological examination. RESULTS The concentration of gastric bile acid was significantly increased in group B-I, or B-II and SV+A than that in group HSV (P<0.05-0.01). The abnormal histological changes in the remnant gastric mucosa were more common in the first 2 groups than in the last group. CONCLUSION The type of gastrectomy can affect bile reflux. The abnormal histological changes in the remnant gastric mucosa are closely related to the elevation of bile acid concentration and increase of TBC in gastric juice. HSV can effectively prevent bile reflux and keep the gastric physiological functions stable.
Clinical value and safety of liver biopsies in patients transplanted for hepatitis C virus‐related end‐stage liver disease

Hepatitis C is the leading indication for liver transplantation. Differentiation between recurrent graft hepatitis C (RGH‐C) and graft rejection (GR) is challenging. Liver biopsy is standard to diagnose both conditions; however, little information is available regarding this procedure in hepatitis C virus (HCV)‐infected liver transplant recipients.
Wheat acreage detection by extended support vector analysis with multi-temporal remote sensing images

An Extended Support Vector Machine (ESVM), which could improve the conventional change detection methods by purifying thematic classification results and neglecting of the side effect by mixed pixel, is proposed for crop acreage measurement by multi-temporal remote sensing land cover change. The ESVM method combines the concept of hard and soft classification and divides the study objects into winter wheat, non-winter wheat and transitional areas. A case study was conducted at DaXing district of Beijing, China, and two remote sensing images from HJ-1/CCD were utilized in ESVM and conventional SVM methods to extract winter wheat area. The results showed that the crop distribution derived from the ESVM reflects reality more accurately than that from SVM. Crops acreage classified from ESVM gave lower RMSE than that from SVM in all window size. This research is therefore demonstrated a new winter wheat detection method which combines hard and soft classification with multi-temporal images.
Empiric radioactive iodine dosing regimens frequently exceed maximum tolerated activity levels in elderly patients with thyroid cancer.

UNLABELLED Although 131I-iodine (RAI) therapy is a mainstay in the treatment of metastatic thyroid cancer, there is controversy regarding the maximum activity that can safely be administered without dosimetric determination of the maximum tolerable activity (MTA). At most institutions, a fixed empiric dosing strategy is often used, with administered activities ranging from 5.55 to 9.25 GBq (150-250 mCi). In our experience with dosimetry, we have observed that this empiric dosing strategy often results in administered RAI activities exceeding the MTA safety limit of 200 cGy (rads) to the blood or bone marrow in many patients with metastatic thyroid cancer. METHODS We retrospectively analyzed 535 hypothyroid dosimetry studies performed as part of routine clinical care in 328 patients with apparently normal renal function. RESULTS The MTA was less than 5.18 GBq (140 mCi) in 3%, less than 7.4 GBq (200 mCi) in 8%, and less than 9.25 GBq (250 mCi) in 19%. Analysis of MTA values by age at the time of dosimetry revealed little change in the MTA until the age of 70 y, when a significant decrease occurred. An empiric administered activity of 7.4 GBq (200 mCi) would exceed the MTA in 8%-15% of patients less than 70 y old and 22%-38% of patients 70 y old or older. However, administration of 9.25 GBq (250 mCi) would exceed the MTA in 22% of patients less than 70 y old and 50% of patients 70 y old or older. Factors associated with a lowering of MTA to less than 9.25 GBq (250 mCi) were age at dosimetry greater than 45 y, the female sex, subtotal thyroidectomy, and RAI-avid diffuse bilateral pulmonary metastases. CONCLUSION Administered RAI activities of less than 5.18 GBq (140 mCi) rarely exposed blood to more than 200 cGy except in the very elderly. However, administered activities of 7.4-9.25 GBq (200-250 mCi) frequently exceeded the calculated MTA in patients 70 y old or older. Therefore, dosimetry-guided RAI therapy may be preferable to fixed-dose RAI treatment strategies in older patients with thyroid cancer and in patients with RAI-avid diffuse bilateral pulmonary metastases, even when renal function is normal.
Enhanced prostaglandin E2 production by monocytes in atopic dermatitis (AD) is not accompanied by enhanced production of IL‐6, IL‐10 or IL‐12

AD is associated with a bias of the T helper cells to show increased IL‐4 and reduced interferon‐gamma (IFN‐γ) production. The production of IFN‐γ and IL‐4 and the development of Th cells into either high IFN‐γ or high IL‐4 producers is strongly influenced by factors produced by antigen‐presenting cells (APC), like IL‐12 and prostaglandin E2 (PGE2). IL‐12 selectively enhances IFN‐γ production and favours the development of IFN‐γ‐producing Th cells, whereas PGE2 selectively inhibits IFN‐γ production by Th cells. The aim of this study was to test whether the increased IL‐4/IFN‐γ production ratio by Th cells in AD can be explained by an increased PGE2/IL‐12 production ratio by the APC. Monocytes were used as APC source. PGE2 and IL‐12 production by lipopolysaccharide (LPS)‐stimulated monocytes from 12 AD patients and 12 non‐atopic controls was determined using two complementary experimental systems, whole blood cultures and purified monocytes. In addition, we determined IL‐6 production as a measure of monocyte activation, and IL‐10 production because IL‐12 production by monocytes is highly influenced by endogenously produced IL‐10. The monocytes from AD patients showed normal production levels of IL‐6 and IL‐10, a two‐fold, but non‐significant decrease in IL‐12 production, and a significantly (three‐fold) higher PGE2 production than those from non‐atopic controls. Here we show for the first time that enhanced PGE2 production by monocytes in AD is not accompanied by a general rise in cytokine production. We conclude that AD is indeed associated with an increased PGE2/IL‐12 production ratio by monocytes.
The chronology of depression and distress in men with Peyronie's disease.

INTRODUCTION For the practicing clinician, appreciating Peyronie's disease (PD) significant negative psychological impact is apparent. Despite this, there exists not a single study using validated instruments assessing this issue. AIMS To document the effect of PD on the psychosocial status of men. MAIN OUTCOME MEASURES The Center for Epidemiological Studies Depression scale (CES-D) for evaluation of depression and the SF-36 for quality of life assessment. METHODS Men (N = 92; 54 +/- 11 years of age) presenting for PD evaluation completed the CES-D, Short Form-36 (SF-36), and an inventory regarding PD. Partners were not assessed. RESULTS A vast majority of men (88%) had a partner with a mean partner age of 49 +/- 11 years. The median duration of PD at presentation was 12 (1-360) months. As a whole, 48% were classified as depressed on the CES-D (26% moderate, 21% severe). These subjects were then placed into groups according to the length of time since diagnosis of PD. Length-of-time groups were: 0-6 months, 6-12 months, 12-18 months, and >18 months. The percent of men scoring above the CES-D cutoff for depression remained consistently high with no significant difference across time since diagnosis groups. These results are supported by data from the Mental Health subscale (MHS) of the SF-36 (lower scores indicate lower mental heath). For the entire sample, the MHS standardized mean of 46.80 was significantly lower (P < 0.05) than the general male population standardized mean of 50. The MHS means stayed consistently low (no statistical difference) across time since diagnosis groups. CONCLUSIONS Using validated instruments, we have demonstrated that 48% of men with PD have clinically meaningful depression that would warrant medical evaluation. This high level of depression stayed consistent across time since diagnosis. These data suggest that most men do not psychologically adjust to their diagnosis of PD and all men with PD should be considered appropriate mental health screening.