Miracle-dz/UniFAR-FTUs huggingface dataset:
A Survey of the Criminal Careers of Hospital Order Patients

Summary All men receiving hospital orders (Section 60) in the UK in the year 1963–64 (excluding those receiving restriction orders (Section 60/65)) were followed up over 15 years with regard to (1) subsequent offences and convictions, (2) hospital admissions, and (3) death. Nine per cent of the patients involved could not be traced. Sixteen per cent had died by 1978, a quarter of them by suicide. Of the mentally ill only 4 per cent subsequently committed serious offences (manslaughter, wounding, GBH, robbery, rape or arson), although a further 4 per cent committed assaults repeatedly. Sex crimes were uncommon. Among the mentally subnormal, 7 per cent committed serious sex crimes subsequent to committal. A further 9 per cent were considered to be persistent sex offenders and another 9 per cent were judged to be persistently violent. In general the mentally subnormal were much younger and were detained for much longer than the mentally ill. Since 1964 the use of hospital orders for the detention of such people has become much less frequent. The best predictor of subsequent offences was found by multiple regression analysis to be the number of previous offences: this was especially true for acquisitive offences committed by the young. The mentally ill were less often reconvicted than the mentally subnormal.
Binding of Selenoprotein P to Heparin: Characterization with Surface Plasmon Resonance

Abstract The binding of selenoprotein P to glycosaminoglycans using heparin as a model compound was studied by surface plasmon resonance. It was found that heparin contains two binding sites for selenoprotein P, a highaffinity, lowcapacity site (K[tilde operator]1n) and a lowaffinity, highcapacity site (K [tilde operator] 140n). Binding at both sites is sensitive to pH and ionic strength, and the highaffinity site is abolished by histidine carbethoxylation with diethylpyrocarbonate. The pH and salt dependence of binding suggests electrostatic interactions with heparin. The concentrations of selenoprotein P in plasma ([tilde operator]50n) are sufficiently high to facilitate binding of selenoprotein P to proteoglycans on the vascular endothelium, and this may contribute to the formation of a protective barrier against oxidants such as peroxynitrite or hydroperoxides.
Poor Teenagers'Religion

Empirical research has ignored the effects of poverty on adolescent religion even though children are far more likely than adults to live in poverty in the United States. The current research demonstrates considerable differences in the religious activities and religious viewpoints of poor and non-poor, American teenagers. Analysis of National Study of Youth and Religion survey data shows that while poor teenagers are especially likely to pray, read religious scriptures, and report high levels of personal faith, they are unlikely to regularly participate in organized religious activities. Other findings include poor teenagers’ emphasis on role reversal in the afterlife, their apparently conventional levels of interaction with secular society, and their low likelihood of reporting the types of emotional religious experiences that are commonly associated with lower class religion. The findings highlight the important role poverty plays in shaping the religious outlooks and activities of adolescents, as well as the need for researchers to consider the role of social class when analyzing Americans’ religious beliefs and activities.
Natural history of COPD: Focusing on change in FEV1

The natural history of chronic obstructive pulmonary disease (COPD) is usually described with a focus on change in forced expiratory volume in 1 s (FEV1) over time as this allows for exploration of risk factors for an accelerated decline—and thus of developing COPD. From epidemiological studies we have recognized important risk factors such as smoking, exposure to biomass and occupational exposures, but we have also learnt about features such as chronic bronchitis, airway hyper‐responsiveness and asthma that seem to accelerate decline in FEV1 independent of exposures. In addition we are gradually beginning to better link early life events to subsequent risk of disease in adulthood. Although more complicated, our current understanding of COPD has come a long way from being a simple image of smoking leading to poor lungs.
Prognostic significance of surface marker expression on blasts of patients with de novo acute myeloblastic leukemia.

The prognostic significance of the expression of surface membrane antigens on the blasts of 123 consecutive patients with de novo acute myeloblastic leukemia (AML) was evaluated. For this purpose, reactivity of monoclonal antibodies (mAbs) CLB-ERY3 (antiblood-group H antigen), VIM-D5 (CD15), WT1 (CD7), MY7 (CD13), MY9 (CD33), VID-1 (antihuman leukocyte antigen locus DR [anti-HLA DR]), VIM-2 (CDw65L), VIM-13 (CD14), 63D3 (CD14) and anti-TdT with leukemic blast cell populations was prospectively analyzed with respect to the rates of complete remission (CR), continuous complete remission (CCR), and survival. The overall rate of CR was 65%, the 6-year rates of overall CCR and survival were 23% and 13%, respectively (median period of patient observation, 30 months). Of all Abs tested, four (CLB-ERY3, MY7, anti-TdT, and VIM-D5) were found to be of prognostic value. Reactivity of CLB-ERY3, MY7, and anti-TdT was predictive for CR (CLB-ERY3+, 43% v CLB-ERY3-, 73%, P less than .02; MY7+, 59% v MY7-, 91%, P less than .003; TdT+, 28% v TdT-, 71%, P less than .001, respectively) and probability of survival (significantly lower survival rates: CLB-ERY3+, P less than .02; MY7+, P less than .03; and TdT+ cases, P less than .001, respectively). Reactivity of VIM-D5 was significantly associated with a higher probability of CCR (P less than .01). Our results confirm earlier reports on the prognostic significance of expression of CD13 and TdT in AML and indicate CLB-ERY3 (antiblood-group H antibody) and VIM-D5 (CD15) as further markers predictive for the clinical outcome in patients with de novo AML.
In Vivo Radioprotection by 5-Androstenediol: Stimulation of the Innate Immune System

Abstract Whitnall, M. H. , Inal, C. E. , Jackson, W. E. , III, Miner, V. L. , Villa, V. and Seed, T. M. In Vivo Radioprotection by 5-Androstenediol: Stimulation of the Innate Immune System. Radiat. Res. 156, 283–293 (2001). We showed previously that 5-androstenediol stimulates myelopoiesis, increases the numbers of circulating neutrophils and platelets, and enhances resistance to infection in γ-irradiated mice. We have extended those studies to include monocytes, natural killer (NK) cells, eosinophils and basophils, and we have measured the activation marker CD11b using flow cytometry. Androstenediol (160 mg/kg) was administered subcutaneously to female B6D2F1 mice 24 h before whole-body γ irradiation. Androstenediol treatments increased the blood levels of neutrophils, monocytes and NK cells in unirradiated animals; decreased the numbers of circulating eosinophils; and ameliorated radiation-induced decreases in neutrophils, monocytes, NK cells, erythrocytes and platelets. The androstenediol treatments had no significant effect on the numbers of circulating B cells or T cells. CD11b labeling intensity on monocytes was decreased slightly after androstenediol treatment. In contrast, radiation or androstenediol alone caused increases in CD11b labeling intensity on NK cells. Androstenediol and radiation combined caused a marked increase in NK cell CD11b. The results indicate that androstenediol increases the numbers of the three major cell types of the innate immune system (neutrophils, monocytes and NK cells), that androstenediol-induced changes in blood elements in irradiated animals persist for at least several weeks, and that there is a significant positive interaction between radiation and administration of androstenediol in the activation of NK cells.
Differential DNA methylation associated with hepatitis B virus infection in hepatocellular carcinoma

Gene inactivation through DNA hypermethylation plays a pivotal role in carcinogenesis. This study aimed to profile aberrant DNA methylation in different stages of liver disease, namely noncirrhosis, cirrhosis and hepatocellular carcinoma (HCC), and also to clarify the influence of hepatitis B virus (HBV) infection on the aberrant DNA methylation in HCCs. Promoter methylation in p14ARF, p16INK4a, O6‐methylguanine‐DNA methyltransferase (MGMT), glutathione S‐transferase pi (GSTP1) and E‐cadherin (E‐Cad) genes of 58 HCCs paired with adjacent nontumorous tissues was assayed by methylation‐specific PCR. HBV infection was determined using a hepatitis B virus surface antigen (HBsAg) serological assay. The frequency of p16INK4a promoter methylation increased from noncirrhotic, cirrhotic, to HCC tissues (noncirrhotic vs. HCC, p < 0.001), while that of GSTP1 promoter methylation increased in cirrhotic tissues compared to noncirrhotic ones (p = 0.029). The frequency of GSTP1 promoter hypermethylation is significantly higher in HCC than in nontumorous tissues (p = 0.022) from HBsAg‐positive patients, but not the HBsAg‐negative controls (p = 0.289). While the frequency of E‐Cad promoter hypermethylation remained high in both nontumorous tissues and HCCs from HBsAg‐positive patients (p = 0.438), it was lower in HCCs than in nontumorous tissues from HBsAg‐negative patients (p = 0.002). In contrast, the frequency of p16INK4a, MGMT and p14ARF promoter hypermethylation in HCCs was unrelated to HBsAg status. In conclusion, aberrant DNA methylation may begin at different stages of liver disease in a gene‐dependent manner. Moreover, HBV infection may enhance or maintain GSTP1 and E‐Cad promoter methylation and thereby affect hepatocarcinogenesis. © 2007 Wiley‐Liss, Inc.
Comparative Evaluation of the Depth of Cure and Degree of Conversion of Two Bulk Fill Flowable Composites.

INTRODUCTION Since the development of resin based composites, several improvements have been made to improve their physical and chemical properties. In an attempt to fasten and simplify the restoration process, a new class of resin based composite materials, called the bulk fill resin based composites have been introduced, which has been claimed to achieve a depth of cure of 4 mm without affecting the properties of the material. AIM To comparatively evaluate the depth of cure of two different bulk fill flowable composite resins by ISO 4049 method and to evaluate the degree of conversion of the same composite resins with Fourier Transform Infrared (FTIR) spectroscopy method. MATERIALS AND METHODS Composite resin specimens (n=10) per group were prepared with bulk fill flowable composites, Surefil SDR flow (Dentsply Caulk, Milford, DE, USA) designated as Group A and Filtek bulk fill (3M ESPE, St.Paul, MN, USA) designated as Group B. Depth of cure was determined according to "ISO 4049; Depth of Cure" method, and FTIR spectroscopy method was used to estimate the degree of conversion of both the bulk fill flowable composites. The degree of conversion of monomer to polymer was estimated individually in coronal half (Group A1 and B1) and pulpal half (Group A2 and Group B2) by dividing each specimens into two halves. The data were analysed using Student's unpaired t-test at 5% level of significance. RESULTS The mean depth of cure of Group A was 3.89 mm (±0.103) and for Group B was 3.54 mm (±0.129). The degree of conversion percentage for Group A1=78.51 (±47.8), Group A2= 31.9 (±22.4), Group B1=39.8 (±5.2), Group B2=37.4 (±6.4). Statistical analysis revealed significant difference in the depth of cure between the two bulk fill flowable composites with Group A higher than Group B. The degree of conversion of the coronal half of Group A1 was significantly higher when compared to Group B1. CONCLUSION Surefil SDR bulk fill resin has better depth of cure and degree of conversion compared to Filtek bulk fill composites.
Urinary Prostaglandin D Synthase (β-Trace) Excretion Increases in the Early Stage of Diabetes mellitus

Objective: Circulating levels of lipocalin-type prostaglandin D synthase (L-PGDS)/β-trace reportedly increase in renal failure as well as in cardiovascular injuries. We investigated the alterations of L-PGDS in urine and plasma in the early stage of type-2 diabetic patients. Method: Thirty-six type-2 diabetic patients and 29 normal subjects were studied. Overnight spot urine and plasma samples were obtained in the morning. L-PGDS was measured by ELISA method using anti-L-PGDS antibody. Variables indicating renal function were determined. Results: Plasma L-PGDS concentration was slightly higher in the patients with diabetes mellitus than in the control subjects, whereas the urinary L-PGDS excretion almost doubled in the diabetic patients as compared with that in the control subjects. Plasma L-PGDS was determined by plasma creatinine (Cr) concentration while urinary L-PGDS excretion was correlated solely with urinary protein excretion. There was no relationship between plasma L-PGDS concentration and urinary L-PGDS excretion. The averaged plasma concentration of L-PGDS in the diabetics with a normal Cr level in plasma, corresponding to that in the controls, was determined by the plasma Cr concentration. On the other hand, the urinary L-PGDS excretion was determined by the amount of proteinuria and greater in the diabetics with a normal Cr level in plasma than in the controls even when the patients exhibited urinary protein excretion equal to that in the control subjects. Conclusions: Urinary L-PGDS excretion increased in the early stage of kidney injury in patients with type-2 diabetes mellitus. The urinary excretion was correlated independently with urinary protein excretion even when there was no difference in urinary protein or albumin excretions, thereby suggesting that urinary L-PGDS excretion is possibly a more sensitive indicator of renal injuries than proteinuria. Urinary L-PGDS may thus predict the progression of renal injuries in diabetic patients.
Eigenvector-Based Speech Mask Estimation Using Logistic Regression

In this paper, we use a logistic regression to learn a speech mask from the dominant eigenvector of the Power Spectral Density (PSD) matrix of a multi-channel speech signal corrupted by ambient noise. We employ this speech mask to construct the Generalized Eigenvalue (GEV) beamformer and a Wiener postfilter. Further, we extend the beamformer to compensate for speech distortions. We do not make any assumptions about the array geometry or the characteristics of the speech and noise sources. Those parameters are learned from training data. Our assumptions are that the speaker may move slowly in the nearfield of the array, and that the noise is in the far-field. We compare our speech enhancement system against recent contributions using the CHiME4 corpus. We show that our approach yields superior results, both in terms of perceptual speech quality and speech mask estimation error.
Dermatologic manifestations in HIV-infected patients: a primary care perspective.

OBJECTIVE To document the prevalence of dermatologic manifestations in patients infected with the human immunodeficiency virus (HIV) on presentation to primary medical care. DESIGN Prospective consecutive case series evaluated between June and November 1995. SETTING The HIV intake clinic at an urban hospital. SUBJECTS AND METHODS Ninety-five individuals initiating HIV-related primary care. RESULTS Dermatologic manifestations were found in 82 patients (86%). The most common conditions were dermatophytosis in 32 patients (34%), oral hairy leukoplakia in 22 (23%), and folliculitis in 18 (19%). Well-described HIV-associated dermatologic manifestations such as Kaposi sarcoma, herpes zoster, and psoriasis were uncommon. CONCLUSIONS The high prevalence of treatable skin disorders found in HIV-infected patients underscores the importance of careful and complete skin examination as a fundamental aspect of the initial clinical evaluation in this population.
Efavirenz 600 mg/day versus efavirenz 800 mg/day in HIV-infected patients with tuberculosis receiving rifampicin: 48 weeks results

The potential of drug–drug interaction between efavirenz and rifampicin is a major concern in the treatment of HIV and tuberculosis. The optimal efavirenz dosage is still unclear. Our randomized control trial study recently reported the similar efavirenz level between efavirenz 600 and 800 mg/day in HIV-infected patients receiving rifampicin. We report the similar virological and immunological outcomes at 48 weeks between the two groups. Efavirenz 600 mg/day should be sufficient for concurrent use with rifamipicin.
Keeping linked open data caches up-to-date by predicting the life-time of RDF triples

Many Linked Open Data applications require fresh copies of RDF data at their local repositories. Since RDF documents constantly change and those changes are not automatically propagated to the LOD applications, it is important to regularly visit the RDF documents to refresh the local copies and keep them up-to-date. For this purpose, crawling strategies determine which RDF documents should be preferentially fetched. Traditional crawling strategies rely only on how an RDF document has been modified in the past. In contrast, we predict on the triple level whether a change will occur in the future. We use the weekly snapshots of the DyLDO dataset as well as the monthly snapshots of the Wikidata dataset. First, we conduct an in-depth analysis of the life span of triples in RDF documents. Through the analysis, we identify which triples are stable and which are ephemeral. We introduce different features based on the triples and apply a simple but effective linear regression model. Second, we propose a novel crawling strategy based on the linear regression model. We conduct two experimental setups where we vary the amount of available bandwidth as well as iteratively observe the quality of the local copies over time. The results demonstrate that the novel crawling strategy outperforms the state of the art in both setups.
Effect of 1-(1-naphthylmethyl)-piperazine, a novel putative efflux pump inhibitor, on antimicrobial drug susceptibility in clinical isolates of Enterobacteriaceae other than Escherichia coli.

OBJECTIVES 1-(1-Naphthylmethyl)-piperazine (NMP) has been shown to reverse multidrug resistance (MDR) in Escherichia coli overexpressing RND type efflux pumps, but there is no data on its activity in Enterobacteriaceae other than E. coli. METHODS The antimicrobial susceptibilities of laboratory strains and 167 clinical isolates of Enterobacteriaceae to a variety of antimicrobial agents were determined in the absence and presence of NMP and, for comparison, of Phe-Arg-beta-naphthylamide (PAbetaN), another putative efflux pump inhibitor (EPI). A 4-fold or greater reduction of the MIC after EPI addition was considered significant. RESULTS NMP consistently reduced the MIC of linezolid in Citrobacter freundii, Enterobacter aerogenes and Klebsiella pneumoniae clinical isolates. Significant effects of NMP addition in >50% of tested isolates were also seen for levofloxacin, tetracycline and chloramphenicol in E. aerogenes, and for levofloxacin and tetracycline in K. pneumoniae, whereas no or minor effects were observed in Serratia marcescens. MDR reversal by NMP was more likely in isolates with decreased susceptibility to fluoroquinolones. In most fluoroquinolone-resistant strains the activity was sufficient to render isolates drug-susceptible at clinically achievable concentrations. The activity of PAbetaN was different from that of NMP, suggesting different modes of action of the two putative EPIs. CONCLUSION NMP has moderate activity in reversing MDR in many but not all members of the Enterobacteriaceae family including clinical isolates. Its effects on resistance reversal depend on bacterial species and drug, and are different from those seen with PAbetaN.
Limited Investor Attention and Stock Market Misreactions to Accounting Information

We provide a model in which a single psychological constraint, limited investor attention, explains both under- and over-reaction to different earnings components. Investor neglect of information in current-period earnings about future earnings induces postearnings announcement drift, the strength of which is increasing with the persistence of earnings. Neglect of earnings components causes accruals and cash flows to predict abnormal returns. We derive new untested empirical implications relating the strength of the drift, accruals, and cash flow anomalies to the quality of earnings, to the number of distracting events, and to the volatilities of and correlation between accruals and cash flows.
Motion compensation with one-axis gyroscope and two-axis accelerometer for automotive SAR

On the basis of a previous one-axis accelerom-eter motion compensation system for automotive SAR, an updated scheme is presented in this paper, which contains a one-axis gyroscope and two-axis accelerometer. The requirement for extra Degrees of Freedom (DoF) leads to a new motion signal model. The complete procedure of calculating motion deviation in image display plane (IDP) from the raw roll angle rate and accelerations measured in body frame has been presented. The requirement for the Inertial Measurement Unit (IMU) has been analyzed quantitatively. According to the out-field measurements, the improved motion compensation system can cope with worse road conditions.
Percutaneous transpedicular vertebroplasty with calcium phosphate cement in the treatment of osteoporotic vertebral compression and burst fractures.

OBJECT Osteoporotic vertebral fractures occasionally lead to late-onset collapse, kyphosis, persistent back pain, and disability. The authors describe a series of patients in whom they performed percutaneous vertebroplasty by using calcium phosphate cement (CPC) to obtain early pain relief and improve the integrity of the osteoporotic vertebral body (VB). METHODS Between August 2000 and February 2001, they performed 17 percutaneous transpedicular CPC-assisted vertebroplasty procedures in 16 patients who harbored thoracic or lumbar osteoporotic vertebral fractures. Following repositioning and curettage of the pathological soft tissues, CPC-assisted vertebroplasty was percutaneously performed in four patients with osteoporotic burst fracture and pseudarthrosis (Procedure A). In situ CPC-assisted vertebroplasty was performed in 12 patients with fresh vertebral compression fractures due to osteoporosis (Procedure B). Back pain and low-back pain were evaluated using a visual analog scale (VAS). The deformity index of the VB was measured on a lateral radiograph as the ratio of the VB's height (sum of measurements at anterior, middle, and posterior regions) to its longitudinal diameter. Based on VAS scores, pain was decreased in all patients immediately after surgery, and pain relief was maintained at the last follow up. The mean preoperative deformity index score of the VB was 1.43 in Procedure A and 1.67 in Procedure B; postoperatively scores improved to 1.59 and 1.93, respectively. At the 6-month follow-up examination, the mean deformity index score rebounded to 1.52 in Procedure A and 1.79 in Procedure B. Bone union was documented in all patients. Complications, such as a temporary respiratory insufficiency and a small amount of CPC leakage into the spinal canal, were observed in patients who underwent Procedure B. CONCLUSIONS Percutaneous transpedicular CPC-assisted vertebroplasty is a minimally invasive procedure that provides early relief of pain and prevents vertebral collapse and pseudarthrosis in patients with osteoporotic vertebral fracture.