Miracle-dz/UniFAR-FTUs huggingface dataset:
Does adenosine prevent myocardial micronecrosis following percutaneous coronary intervention? The ADELINE pilot trial

After successful percutaneous coronary intervention (PCI), 24–44% of patients suffer some myocardial damage as indicated by a significant change in the concentrations of cardiospecific troponin or the MB isoenzyme of creatine kinase (CK-MB). 1,2 Patients with minor increases of these cardiac markers after PCI constitute a population with a worse long term prognosis.3 Preconditioning of human myocardium can be obtained by intracoronary administration of adenosine, as indicated by attenuation of ischaemia and chest pain in patients undergoing PCI.4 In the present trial (ADELINE, does ADEnosine Limit myocardial Necrosis), we investigated the effect of intracoronary administration on chest pain and ischaemia during a 90 second balloon inflation during PCI. In addition, we evaluated the release of cardiac markers after angiographically successful coronary intervention. Patients were eligible when a PCI was planned of a lesion in a primary or secondary branch of either coronary artery, supplying a sizeable area of myocardium. Exclusion criteria were: myocardial infarction during the previous two weeks; use of theophylline preparations, dipyridamole or glibenclamide; bronchial asthma; second or third degree atrioventricular block, and recanalisation of a total occlusion. This study was approved by the institutional review board, and written informed consent was obtained from all patients. In this single centre, single blind study, 32 patients were randomly allocated to a control or an adenosine treated group. One patient was excluded because of occlusion of a major branch during PCI, and three patients were excluded because …
Role of hepatitis C virus infection in malignant lymphoma in Spain

Hepatitis C virus (HCV) has been implicated in the etiology of malignant lymphomas. We estimated the risk of lymphoma associated with detection of HCV infection. Cases (n = 529) were consecutive patients newly diagnosed with a lymphoid malignancy between 1998 and 2002 in 4 centers in Spain. Lymphomas were diagnosed and classified using the WHO Classification. Controls (n = 600) were hospitalized patients matched to the cases by 5‐year age group, gender and study center. Several medical conditions associated with severe immunosuppression precluded the eligibility of controls. Patients underwent a personal interview and blood sampling. HCV positive subjects were considered those with antibody response to third generation ELISA or detection of HCV RNA with Amplicor 2.0. Cases were systematically tested for HIV antibodies. We used the χ2 test and unconditional logistic regression to estimate the odds ratio (OR) and 95% confidence interval (95% CI) for lymphoma associated with HCV. HCV infection was detected in 40 cases (7.5%) and 23 (3.8%) control subjects. Six of 16 patients with HIV‐related lymphomas and 4 of 8 organ‐recipient‐related lymphomas were HCV positive. The analysis, excluding HIV‐infected subjects and organ recipients, led to a prevalence of HCV of 5.9% among cases and 3.8% among controls. The age‐, gender‐ and center‐adjusted OR for all lymphomas was 1.58 (95% CI = 0.89–2.79). Among all lymphoma categories, HCV was associated with an increased risk of low grade B‐cell lymphomas not otherwise specified (NOS) (OR = 35.98, 95% CI = 4.70–275.4). A 2‐fold excess risk associated to HCV was observed for marginal B‐cell lymphomas, diffuse large B‐cell lymphoma and lymphoma B NOS but the associations were not statistically significant. HCV infection is associated with an increased risk of a broad spectrum of lymphoid neoplasms among non severely immunocompromised subjects in Spain. © 2004 Wiley‐Liss, Inc.
Preparation and chemical composition of the cell walls of Streptococcus mutans

Purified cell walls from Streptococcus mutans strain BHT were prepared without the use of proteolytic enzymes in order to retain all cell wall constituents for chemical analysis. Of four methods employed, the Ribi cell fractionator produced disrupted cell suspensions which could be most thoroughly purified on sucrose gradients. Results of chemical analyses on purified cell walls prepared in this 8.9% glycerol teichoic acid, 33.6% non-peptidoglycan polysaccharide, and 49.9% peptidoglycan.
A Review of the Effects and Mechanisms of Polyphenolics in Cancer

This paper is a comprehensive review of the effects of bioactive polyphenolic compounds commonly found in many fruits and vegetables on cancer. These include the pheniolic acids, anthocyanins, catechins, stilbenes and several other flavonoids. We have attempted to compile information from most of the major studies in this area into one source. The review encompasses the occurrence and bioavailability of the polyphenolics, the in vitro and in vivo evidence for their effects on cancer, both positive and negative, and the various mechanisms by which the chemicals may exert their effects. Although most of the work done to date indicates a chemopreventative activity of these compounds, there are some studies that show cancer-inducing or no effects. There are several common mechanisms by which these chemicals exert their effects that could be conducive to additive, synergistic, or antagonistic interactions. These include effects on cellular differentiation, proliferation, and apoptosis, effects on proteins and enzymes that are involved in these processes at a molecular level, and other various effects through altered immune function and chemical metabolism.
The dominant‐negative effect of the Q218K variant of the prion protein does not require protein X

Previous studies identified several single‐point mutants of the prion protein that displayed dominant‐negative effects on prion replication. The dominant‐negative effect was assumed to be mediated by protein X, an as‐yet‐unknown cellular cofactor that is believed to be essential for prion replication. To gain insight into the mechanism that underlies the dominant‐negative phenomena, we evaluated the effect of the Q218K variant of full‐length recombinant prion protein (Q218K rPrP), one of the dominant‐negative mutants, on cell‐free polymerization of wild‐type rPrP into amyloid fibrils. We found that both Q218K and wild‐type (WT) rPrPs were incorporated into fibrils when incubated as a mixture; however, the yield of polymerization was substantially decreased in the presence of Q218K rPrP. Furthermore, in contrast to fibrils produced from WT rPrP, the fibrils generated in the mixture of WT and Q218K rPrPs did not acquire the proteinase K‐resistant core of 16 kDa that was shown previously to encompass residues 97–230 and was similar to that of PrPSc. Our studies demonstrate that the Q218K variant exhibits the dominant‐negative effect in cell‐free conversion in the absence of protein X, and that this effect is, presumably, mediated by physical interaction between Q218K and WT rPrP during the polymerization process.
Women's perspectives on illness when being screened for cervical cancer

Background In Greenland, the incidence of cervical cancer caused by human papillomavirus (HPV) is 25 per 100,000 women; 2.5 times the Danish rate. In Greenland, the disease is most frequent among women aged 30–40. Systematic screening can identify women with cervical cell changes, which if untreated may cause cervical cancer. In 2007, less than 40% of eligible women in Greenland participated in screening. Objective To examine Greenlandic women's perception of disease, their understanding of the connection between HPV and cervical cancer, and the knowledge that they deem necessary to decide whether to participate in cervical cancer screening. Study design The methods used to perform this research were 2 focus-group interviews with 5 Danish-speaking women and 2 individual interviews with Greenlandic-speaking women. The analysis involved a phenomenological-hermeneutic approach with 3 levels of analysis: naive reading, structural analysis and critical interpretation. Results These revealed that women were unprepared for screening results showing cervical cell changes, since they had no symptoms. When diagnosed, participants believed that they had early-stage cancer, leading to feelings of vulnerability and an increased need to care for themselves. Later on, an understanding of HPV as the basis for diagnosis and the realization that disease might not be accompanied by symptoms developed. The outcome for participants was a life experience, which they used to encourage others to participate in screening and to suggest ways that information about screening and HPV might reach a wider Greenlandic population. Conclusion Women living through the process of cervical disease, treatment and follow-up develop knowledge about HPV, cervical cell changes, cervical disease and their connection, which, if used to inform cervical screening programmes, will improve the quality of information about HPV, cervical cancer and screening participation. This includes that verbal and written information given at the point of screening and diagnosis needs to be complemented by visual imagery.
Paraneoplastic Limbic Encephalitis in Hodgkin’s Disease

ABSTRACT: Background: Oat cell carcinoma of the lung is the most common cause of paraneoplastic limbic encephalitis. Association with other malignancies, in particular Hodgkin’s disease, is very rare. Case Report: This 23-year-old male presented with a six month history of progressive alteration in mental status, which consisted of insomnia, short-term memory loss, depression and cognitive impairment. Gadolinium MRI of the head showed intense bilateral contrast enhancement affecting the medial aspects of the temporal lobes in the region of the amygdala and hippocampus. The brain biopsy showed minimal neuronal loss with intense perivascular lymphocytic cuffing and microglia] nodules. Polymerase chain reaction for herpes simplex and cytomegalovirus were negative. With prednisone treatment, the patient’s neurologic status stabilized but did not improve. Four months later, he presented with left axillary lymphadenopathy. Lymph node biopsy was diagnostic of Hodgkin’s disease. During the chemotherapy, his lymphadenopathy subsided and his neurologic and mental status improved. When seen last after completion of his chemotherapy, one year after presentation, he had resumed normal social activities and was enrolled in a university language course. Conclusion: This is the first reported case in the English literature of a biopsy proven paraneoplastic limbic encephalitis associated with Hodgkin’s disease. Hodgkin’s disease should be thought of as a possible cause of paraneoplastic limbic encephalitis in the appropriate clinical setting.
Open-Area Seclusion in the Long-Term Treatment of Aggressive and Disruptive Psychotic Patients, an Introduction to a Ward Procedure

The clinical rationale and procedure of “open-area seclusion” as a treatment modality with psychotic patients is presented. This standard procedure was originally introduced as an alternative to arbitrary measures in response to aggressive and disruptive behavior. The seclusion area is locked, but the patient is never locked up alone in any single room. The method of open-area seclusion is composed of four overlapping phases: (1) assisting the patient to the seclusion area, (2) time for a “calming down” process, (3) debriefing, and (4) reintegration. Verbal confrontation is central in enhancing the secluded patient's reality-testing, for reinforcing responsibility for one's own behavior, and for encouraging alternative problem-solving. A step-by-step description of the procedure of open-area seclusion is presented and illustrated by a case history.
Teori common link G.H.A. Juynboll

Sebagian besar ahli hadis beranggapan bahwa apabila sebuah hadis tertentu yang disandarkan kepada nabi saw. ditemukan dalam koleksi hadis kanonik, lebih-lebih dalam Şaḥīḥ Bukhari dan Muslim, maka dengan sendirinya hadis itu bersumber dari nabi saw. Namun, berdasarkan temuan G.H. A Juynboll (1935-2010 M) dengan menggunakan teori common link, walaupun sebuah hadis tertentu telah direkam dalam al-kutub al-sittah, tetapi hadis itu belum tentu berasal dari nabi saw. Tujuan pertama disertasi ini adalah mengkaji teori common link G.H. A. Juynboll dan implikasinya terhadap persoalan asal-usul dan perkembangan awal hadis. Teori common link yang berpijak pada asumsi yang berbeda dengan asumsi metode kritik hadis di kalangan muḥadditsin pada gilirannya menimbulkan akibat yang cukup mengejutkan ahli hadis pada khususnya dan umat Islam pada umumnya. Tujuan kedua adalah menguji kembali kebenaran teori tersebut dengan cara menerapkannya pada hadis-hadis tentang syahadat dan rukun Islam dan menawarkan penafsiran baru tentang fenomena common link dan fenomena lainnya. Verifikasi teori common link membuktikan bahwa teori ini dapat diterima kebenarannya sebagai sebuah metode untuk menelusuri asal-usul hadis. Teori tersebut dapat memberikan jawaban yang lebih akurat dan memadai mengenai kapan, di mana, dan oleh siapa sebuah hadis mulai disebarkan secara publik. Namun berbeda dengan Juynboll yang menganggap common link sebagai seorang pemalsu (fabricator) hadis yang bertanggungjawab atas perkembangan isnād dan matan hadis dan bahwa bampir tidak pemah seorang sahabat memainkan peranan sebagai common link, studi ini membuktikan bahwa common link adalah seorang periwayat yang menjadi titik pindah dari periode periwayatan hadis secara individual ke periode periwayatan hadis secara publik dan massal. Common link bukanlah seorang pemalsu hadis. Ia adalah orang pertama yang meriwayatkan hadis dengan kata-katanya sendiri, tetapi substansi maknanya tetap memiliki kesinambungan dengan tokoh yang lebih tua daripada dirinya, baik sahabat maupun nabi saw. Studi ini juga menunjukkan bahwa seorang periwayat yang menduduki posisi common link dalam sebuah bundel isnād berasal dari generasi yang beragam: generasi sahabat kecil, tabiin atau tabiit tabiin walaupun sebagian besar periwayat yang menduduki posisi tersebut berasal dari generasi tabiin.
In Vitro Regulation of Enzymes of the Renin-angiotensin-aldosterone System by Isoquercitrin, Phloridzin and their Long Chain Fatty Acid Derivatives

Background: Hypertension is a crucial risk factor for development of cardiovascular and neurological diseases. Flavonoids exhibit a wide range of biological effects and have had increased interest as a dietary approach for the prevention or possible treatment of hypertension. However, continuous efforts have been made to structurally modify natural flavonoids with the hope of improving their biological activities. One of the methods used for the possible enhancement of flavonoid efficacy is enzymatic esterification of flavonoids with fatty acids. Objective: The current study is designed to investigate the antihypertensive activity of isoquercitrin (quercetin-3- O -glucoside, Q3G) and phloridzin (PZ) in comparison to their twelve long chain fatty acid derivatives via enzymatic inhibition of renin angiotensin aldosterone system (RAAS) enzymes. Methods: The novel flavonoid esters were synthesized by the acylation of isoquercitrin and phloridzin with long chain unsaturated and saturated fatty acids (C 18 –C 22 ). These acylated products were then tested for their in vitro angiotensin converting enzyme (ACE), renin and aldosterone synthase activities. Results: The linoleic and α-linolenic acid esters of PZ were the strongest (IC 50 69.9-70.9 µM) while Q3G and PZ (IC 50 >200 µM) were the weakest renin inhibitors in vitro (p≤0.05). The eicosapentaenoic acid ester of PZ (IC 50 16.0 µM) was the strongest inhibitor of ACE, while PZ (IC 50 124.0 µM) was the weakest inhibitor (p≤0.05) among all tested compounds. However, all investigated compounds had low (5.0-11.9%) or no effect on aldosterone synthase inhibition (p≤0.05). The parent compound Q3G and the eicosapentaenoic acid ester of PZ emerged as the strongest ACE inhibitors. Conclusions: The structural modification of Q3G and PZ significantly improved their antihypertensive activities. The potential use of PZ derivatives as natural health products to treat hypertension needs to be further evaluated. Keywords: hypertension, phloridzin, isoquercitrin, flavonoids, ACE, renin, RAAS, acylation, fatty acids
Nonlinear interdependence of the Chinese stock markets

The methodologies and assumptions in financial integration studies are problematic and may lead to spurious empirical results. Using surrogate data analysis and the mutual prediction method of testing for nonlinear interdependence, it is feasible for an analyst, with a scant knowledge of the underlying dynamics of two dynamical systems, to show whether or not the systems are interdependent. This study applies these techniques in testing for nonlinear interdependence of three Chinese stock markets: Shanghai, Shenzhen, and Hong Kong. The empirical results of the present study indicate that the stock market series are nonlinear and that the Chinese stock exchanges are nonlinearly interdependent. Specifically, the evidence indicates that Shanghai and Shenzhen markets are bi-directionally interdependent, while Shanghai and Hong Kong as well as Shenzhen and Hong Kong markets are unidirectionally interdependent, with the direction of interdependence going from the mainland's markets to the Hong Kong market.
Comparative Study of Predictive and Resonant Controllers in Fault-Tolerant Five-Phase Induction Motor Drives

One of the most attractive features of multiphase machines is the fault-tolerant capability due to the higher number of phases. Different postfault control strategies based on hysteresis, proportional integral (PI)-resonant, and predictive techniques have been recently proposed. They all proved their capabilities to withstand fault situations and to preserve the fundamental component of the air-gap field, while achieving minimum losses, maximum torque per ampere, and reducing torque vibrations. Nonetheless, due to their recent introduction, no thorough study has yet appeared comparing the performance of these controllers. In this paper, two open-phase fault-tolerant control schemes are experimentally compared in a real five-phase induction machine. The controllers being compared are based on PI-resonant and predictive control techniques, respectively. The experiments include pre- and postfault situations. Obtained results show that both control methods offer nearly the same performance. When compared, predictive control provides faster control response and superior performance at low-speed operation but is found to be less resilient to fault detection delays and to have higher current ripple. Regarding the controller implementation, it is shown that the transition from prefault to postfault operation involves modeling the nonlinear effects observed when an open-phase fault occurs for the predictive controller and proper retuning of the PI trackers for the PI-resonant controller, to ensure postfault operation.
A comparison between previous and present histologic assessments of chronic hepatitis C viral infections in humans.

AIM:To compare the previously employed classification of liver histology (minimal,chronic persistent hepatitis, chronic active hepatitis and cirrhosis) with a new classification recently described by sheuer et al (activity grade and fibrosis stage) in percutaneous liver biopsies from patients with chronic hepatitis C viral infections.METHODS:Liver biopsies from 79 untreated patients were reviewed. Anti-HCV testing had been performed by ELISA and confirmed by a recombinant immunoblot assay.With respect to the new classification, all the specimens were evaluated using the Knodell score for activity.RESULTS:A good correlation was revealed between the previous and more recent histologic classifica-tions in patients with abnormal liver enzyme tests. However, in 13/15 (87%) of patients with normal aminotransferase values, changes were consistent with chronic persistent hepatitis whereas normal activity and no fibrosis were demonstrated by the Sheuer classifica-tion.CONCLUSION:The old classification is more often mislead-ing but correlates well with the new classification and thereby permits comparisons between historically clinical studies.
Relationship between the big-five personality dimensions and speed of information processing among adolescents

A developmental research of the relationship between the Big-Five and speed of information processing (SIP) was conducted with the aim of considering the personality-intelligence relationship. Personality dimensions were assessed by International Personality Item Pool (IPIP) questionnaire, while SIP and related test errors (Er-SIP) were assessed by Cognitive Abilities (KS2-2) pencil and paper perceptual speed test. The sample consisted of 1063 adolescents (378 males) at the age range from 14 to 18. The preliminary analyses showed that: (1) age related changes of SIP were weak and those of personality dimensions barely existed, (2) modest gender differences are found for all personality dimensions except for Intellect, and they are not found for SIP and Er-SIP, (3) reduced variability and significant distribution skewness systematically appeared only at Er-SIP, and (4) personality dimensions-SIP relationship was not curvilinear. The main analyses showed that: (1) SIP had low positive correlations only with Extraversion and Agreeableness, (2) Er-SIP didn't correlate with personality dimensions at all and (3) personality dimensions-SIP relationship mostly insignificantly depends on age and gender.
Quando o jogo flui: uma investigação sobre a teoria do fluxo no voleibol

As experiencias subjetivas dos atletas geralmente sao negligenciadas nas pesquisas no contexto esportivo devido a uma enfase no desempenho e nos resultados. O fluxo e um conceito de grande importância e relevância direta para o esporte; descreve um estado mental otimo no qual os atletas se tornam completamente absorvidos em suas tarefas, as acoes sao realizadas sem a percepcao de esforco, e a percepcao da passagem do tempo e distorcida. O estado de fluxo pode ocorrer em qualquer nivel de habilidade, desde que haja um equilibrio ideal entre o desafio percebido e o nivel de habilidade. Frequentemente ha um aumento no desempenho durante o estado de fluxo. O objetivo deste estudo e discutir como o conceito do fluxo pode aumentar a compreensao das experiencias subjetivas dos atletas. Questoes conceituais relacionadas a pesquisa sobre o fluxo no esporte sao apresentadas, seguidas por dois estudos realizados visando a compreensao de como este estado ideal e vivenciado por atletas de voleibol. O primeiro estudo, uma pesquisa qualitativa sobre as experiencias de fluxo de atletas, tem como objetivo obter maior conhecimento sobre a natureza do fluxo no voleibol. Doze jogadores foram entrevistados sobre suas experiencias de jogo ideais, e em seguida, questionados extensivamente sobre os fatores que interferem no alcance do estado mental otimo durante o desempenho. Foram encontradas correspondencias entre as dimensoes do fluxo, como descritas por Csikszentmihalyi (1990), e as descricoes dos atletas de suas experiencias de fluxo; algumas dimensoes receberam maior suporte do que outras na analise qualitativa. As dimensoes do fluxo mais citadas pelos atletas foram experiencia autotelica, equilibrio entre desafios e habilidades, percepcao de controle e concentracao total. O segundo estudo investiga a relacao entre fluxo e outras variaveis psicologicas como motivacao, orientacao para as metas, autoeficacia e capacidade percebida. Analises correlacionais foram conduzidas para examinar os correlatos psicologicos do estado de fluxo. Padroes positivos de relacionamento foram encontrados entre o fluxo e a habilidade percebida, a autoeficacia e a orientacao para a tarefa. O entendimento do fluxo e sua relacao com as outras variaveis foram tambem discutidos.