Miracle-dz/UniFAR-FTUs huggingface dataset:
Difference Approximations of the Neumann Problem for the Second Order Wave Equation

Stability theory and numerical experiments are presented for a finite difference method that directly discretizes the Neumann problem for the second order wave equation. Complex geometries are discretized using a Cartesian embedded boundary technique. Both second and third order accurate approximations of the boundary conditions are presented. Away from the boundary, the basic second order method can be corrected to achieve fourth order spatial accuracy. To integrate in time, we present both a second order and a fourth order accurate explicit method. The stability of the method is ensured by adding a small fourth order dissipation operator, locally modified near the boundary to allow its application at all grid points inside the computational domain. Numerical experiments demonstrate the accuracy and long-time stability of the proposed method.
Simply distracting learners is not enough: More evidence for the learning benefits of an external focus of attention

This experiment followed up on previous studies showing learning benefits of instructions directing the performers' attention to the effects of their movements (external focus) relative to instructions directing attention to the movements themselves (internal focus). The main purpose was to determine whether similar advantages could be achieved by preventing learners from focusing on their movements through the use of an attention-demanding secondary task. Participants practiced balancing on a stabilometer. External and internal focus group participants were instructed to focus on markers attached to the balance platform or on their feet, respectively. A third group was required to shadow a story presented to them while balancing. In addition, a control group without attentional focus instructions or a secondary task was included. The external focus group showed more effective balance learning than the other groups. The results provide evidence for the learning benefits of external focus instructions. In addition, they show that similar advantages cannot be achieved by simply preventing learners from focusing on the task to be learned.
Mobile App and App Store Analysis, Testing, and Optimisation

This talk presents results on analysis and testing of mobile apps and app stores, reviewing the work of the UCL App Analysis Group (UCLappA) on App Store Mining and Analysis. The talk also covers the work of the UCL CREST centre on Genetic Improvement, applicable to app improvement and optimisation.
From art to project: the cross-border diffusion of a social innovation on the Belgian labor market

Social innovation has been the focus of an increasing scholarly attention over the last decade (Howaldt & Schwarz 2010; Moulaert et al. 2013). This literature, however, has struggled with definitional problems and has remained rather descriptive and under-theorized, with only limited connections with broader theories in organization studies (Nicholls & Murdock 2012). Typically, it has been suggested that social innovation is characterized by specific diffusion (or “scaling up”) mechanisms that aim for wide replication and adoption, rather than control and profits for the pioneer innovators (Mulgan et al. 2007; Murray et al. 2010). Besides a lack of empirical validation, this hypothesis has also insufficiently been connected with theories that precisely focus on how new institutional arrangements emerge, are diffused and impact the broader institutional landscape, i.e. institutional entrepreneurship (Dorado 2005; Garud et al. 2002; Leca et al. 2008; Maguire et al. 2004) and more broadly institutional work (Lawrence & Suddaby 2006; Lawrence et al. 2009). This gap is even more surprising that most social innovations precisely aim to solve a social problem by challenging extant institutional arrangements, at least through discursive work theorizing intended institutional changes.
Be successful, take a hostage or "outsourcing the outsourcing Manager"

Working on a project where the work is distributed across the globe need not be a dreadful experience. It is possible to set up a distributed team so that the regular team members are not affected by the issues pertaining to the aspects of the global setup. This paper sheds some light on the problems discovered , analyzes what often goes wrong and suggests one of many possible solutions. Take the "full service" approach; outsource the management of the outsourced project. Using an example of a project done between the USA West Coast and Slovakia advantages of the proposed solution are evident.
The negative regulator Opi1 of phospholipid biosynthesis in yeast contacts the pleiotropic repressor Sin3 and the transcriptional activator Ino2

Structural genes of phospholipid biosynthesis in the yeast Saccharomyces cerevisiae are transcriptionally co‐regulated by ICRE (inositol/choline‐responsive element) promoter motifs. Gene activation by an ICRE is mediated by binding of the Ino2/Ino4 transcription factor, whereas repression in the presence of high concentrations of inositol and choline (IC) requires an intact Opi1 repressor. However, the mechanism of specific repression and the functional interplay among these regulators remained unclear from previous work. Using in vivo as well as in vitro interaction assays, we show binding of the pleiotropic repressor Sin3 to the pathway‐specific regulator Opi1. The paired amphipathic helix 1 (PAH1) within Sin3 and OSID (Opi1–Sin3 interaction domain) in the N‐terminus of Opi1 were mapped as contact sites. The regulatory significance of the Opi1–Sin3 interaction was shown by the obvious deregulation of an ICRE‐dependent reporter gene in a sin3 mutant. Opi1 also interacts with a newly identified functional domain of the transcriptional activator Ino2 (RID, repressor interaction domain). These results define the molecular composition of the transcription complex mediating control of ICRE‐dependent genes and allow a hypothesis on the flow of regulatory information in response to phospholipid precursors.
Computational site‐directed mutagenesis studies of the role of the hydrophobic triad on substrate binding in cholesterol oxidase

Cholesterol oxidase (ChOx) is a flavoenzyme that oxidizes and isomerizes cholesterol (CHL) to form cholest‐4‐en‐3‐one. Molecular docking and molecular dynamics simulations were conducted to predict the binding interactions of CHL in the active site. Several key interactions (E361‐CHL, N485‐FAD, and H447‐CHL) were identified and which are likely to determine the correct positioning of CHL relative to flavin‐adenine dinucleotide (FAD). Binding of CHL also induced changes in key residues of the active site leading to the closure of the oxygen channel. A group of residues, Y107, F444, and Y446, known as the hydrophobic triad, are believed to affect the binding of CHL in the active site. Computational site‐directed mutagenesis of these residues revealed that their mutation affects the conformations of key residues in the active site, leading to non‐optimal binding of CHL and to changes in the structure of the oxygen channel, all of which are likely to reduce the catalytic efficiency of ChOx. Proteins 2017; 85:1645–1655. © 2017 Wiley Periodicals, Inc.
Biotoxic effects of the herbicides on growth, seed yield, and grain protein of greengram

We studied the effects of atrazine, isoproturon, metribuzin and sulfosulfuron on plant vigour, nodulation, chlorophyll content, seed yield and protein content in seeds, in greengram inoculated with Bradyrhizobium sp. (vigna ). The pre-emergence application of the four herbicides at 400 µg kg -1 of soil adversely affected the measured parameters. The average maximum increase of 10 % in seed yield occurred at 200 µg kg-1 of sulfosulfuron, while atrazine at 200 and 400 µg kg -1 of soil decreased the seed yield by 25 % and 40%, respectively. The average maximum chlorophyll content of 1.2 mg g -1 was obtained at 200 µg kg -1 of sulfosulfuron which declined consistently for all herbicides and increasing dose rates. Sulfosulfuron at 200 µg kg -1 increased the number of nodules found per plant by 7 % at 45 days after seeding the greengram. In contrast, the tested dose rates of atrazine, isoproturon and metribuzin significantly reduced the nodulation (nodule number and dry mass). The average maximum grain protein of 182 mg g -1 was obtained for sulfosulfuron at 400 µg kg-1, while minimum grain protein was obtained at 400 µg kg -1 - of isoproturon (124 mg g -1 ) and atrazine (125 mg g -1 ) application. Among the herbicides tested, atrazine and metribuzin showed a large degree of phytotoxicity to the crop, inhibiting its vegetative growth and was thus incompatible with greengram. Journal of Applied Sciences and Environmental Management Vol. 10(3) 2006: 141-146
Polysaccharide vaccines as probes of antibody repertoires in man

Summary: Antibodies specific for capsular polysaccharide epitopes mediate immunity to encapsulated bacterial pathogens, and accordingly, vac‐cine development has focused upon the induction of these specificities. Efficacious vaccines, consisting of either polysaccharide alone or polysaccharide coupled to protein carriers, have been developed for a number of pathogens. Their clinical importance not with standing, these vaccines serve as model antigens to study the genetic and somatic forces molding adaptive immunity in man. In this article we review progress aimed at delineating the structure and dynamics of the human antibody repertoire to the Hoemophilus influenzoe type b poiysaccharide (Hib PS), a system which has been studied from infancy to old age. Collectively, the data reveal a repertoire which is encoded by a relatively iarge number of germline variable (V) region gene segments, but which is typically expressed within individuals as a markedly restricted, oligoclonal population. One particular V domain has attained canonical status because of its high penetrance at the population level and its predominance in individual repertoires, Although this combining site is assembled in early infancy and retains its prominence throughout life, its frequency of expression, affinity and protective function are dictated by the molecular form of the Hib PS immunogen (vaccine). The determinants of Hib PS binding affinity can include both germline and somatically‐acquired V region polymorphisms. We discuss how these properties of the Hib PS repertoire could impact immunity to Htb, and we consider the implications of these findings towards understanding die evolution of immunoglobulin germline V genes.
Research data management and openness: The role of data sharing in developing institutional policies and practices

Purpose – The purpose of this paper is to investigate the relationship between research data management (RDM) and data sharing in the formulation of RDM policies and development of practices in Higher Education Institutions (HEIs). Design/methodology/approach – Two strands of work were undertaken sequentially: first, content analysis of 37 RDM policies from UK HEIs; and second, two detailed case studies of institutions with different approaches to RDM based on semi-structured interviews with staff involved in the development of RDM policy and services. The data are interpreted using insights from Actor Network Theory. Findings – RDM policy formation and service development has created a complex set of networks within and beyond institutions involving different professional groups with widely varying priorities shaping activities. Data sharing is considered an important activity in the policies and services of HEIs studied, but its prominence can in most cases be attributed to the positions adopted by larg.
Frequent side chain methyl carbon‐oxygen hydrogen bonding in proteins revealed by computational and stereochemical analysis of neutron structures

The propensity of backbone Cα atoms to engage in carbon‐oxygen (CH···O) hydrogen bonding is well‐appreciated in protein structure, but side chain CH···O hydrogen bonding remains largely uncharacterized. The extent to which side chain methyl groups in proteins participate in CH···O hydrogen bonding is examined through a survey of neutron crystal structures, quantum chemistry calculations, and molecular dynamics simulations. Using these approaches, methyl groups were observed to form stabilizing CH···O hydrogen bonds within protein structure that are maintained through protein dynamics and participate in correlated motion. Collectively, these findings illustrate that side chain methyl CH···O hydrogen bonding contributes to the energetics of protein structure and folding. Proteins 2015; 83:403–410. © 2014 Wiley Periodicals, Inc.
Bilateral subthalamic nucleus stimulation and quality of life in advanced Parkinson's disease

We examined the impact of the subthalamic nuclei (STN) deep brain stimulation (DBS) on the health‐related quality of life (QoL) of patients with advanced Parkinson's disease (PD). Seventeen consecutive patients with refractory motor fluctuations and dyskinesia were included in the study (mean age, 60.9 ± 7.7 years [range, 43–74 years]; disease duration, 16.4 ± 8.5 years [range, 7–38 years]; mean off‐medication Hoehn and Yahr stage, 4.23 ± 0.66 [range, 2.5–5]). Each patient's assessment was carried out using common rating scales, following the Core Assessment Program for Intracerebral Transplantation (CAPIT) protocol. Dyskinesia and emotional state were evaluated through the Abnormal Involuntary Movement Scale (AIMS) and the Hospital Anxiety and Depression Scale (HAD). QoL was assessed by means of the Parkinson's Disease Questionnaire Spanish version (PDQ‐39). Significant benefit was obtained in the motor manifestations and complications of disease, as well as in the functional state and mood (P < 0.001). Some QoL dimensions (mobility and activities of daily living) and the PDQ‐39 Summary Index (PDQ‐39SI) showed a significant improvement (P < 0.001). Benefit was modest (P < 0.05) for three other domains (emotional well‐being, stigma, bodily discomfort) and nil for the rest. There was no correlation between the change obtained in the QoL (PDQ‐39SI) and in the other variables. As measured by the PDQ‐39, STN‐DBS significantly improves important aspects of QoL in patients with advanced PD. © 2002 Movement Disorder Society.
Concern for a lack of comprehensive assessment in the identification of reading disabilities is compounded by the current movement in the school psychology field toward the RTI model

Response to intervention (RTI) must be combined with comprehensive cognitive assessment to identify children with learning disabilities. This article presents the Cognitive Hypothesis Testing (CHT) model for integrating RTI and comprehensive evaluation practices in the identification of children with reading disabilities. The CHT model utilizes a scientific method approach for interpreting cognitive and neuropsychological processes together with evaluation of ecological and treatment validity data to develop targeted interventions for students who do not respond to standard academic interventions. A case study highlights how CHT practices can lead to effective interventions for a child who did not respond to a phonologically based reading intervention. In addition, discriminant analyses of 128 children with reading disabilities revealed the presence of Global, Phonemic, Fluency-Comprehension, and Orthographic subtypes. Results suggest subtypes show disparate cognitive profiles that differentially impact their reading achievement, supporting our contention that individual assessment of cognitive processing strengths and weaknesses is not only necessary for identifying children with reading disabilities but also can lead to individualized interventions designed to meet their unique learning needs. © 2006 Wiley Periodicals, Inc.
Linköping University Post Print Industrial-scale deposition of highly adherent CN x films on steel substrates

Abstract Highly adherent carbon nitride (CN x ) films were deposited using a novel pretreatment with two high power impulse magnetron sputtering (HIPIMS) power supplies in a master-slave configuration: one to establish the discharge and one to produce a pulsed substrate bias. During the pretreatment, SKF3 (AISI 52100) steel substrates were pulse-biased in the environment of a HIPIMS Cr plasma in order to sputter clean the surface and to implant Cr metal ions. Subsequently, CN x films were prepared at room temperature by DC unbalanced magnetron sputtering from a high purity graphite target in a N 2 /Ar discharge at 3 mTorr. All processing was done in an industrial CemeCon CC800 system. A series of depositions were obtained with samples at different bias voltages (DC and pulsed) in the range 0-800 V. Scanning transmission microscopy (STEM) and high resolution transmission electron microscopy (HRTEM) show the formation of an interface comprising a polycrystalline Cr layer of 100 nm and an amorphous transition layer of 5 nm. The adhesion of CN
Activation of Transferrin Receptor 1 by c-Myc Enhances Cellular Proliferation and Tumorigenesis

ABSTRACT Overexpression of transferrin receptor 1 (TFRC1), a major mediator of iron uptake in mammalian cells, is a common feature of human malignancies. Therapeutic strategies designed to interfere with tumor iron metabolism have targeted TFRC1. The c-Myc oncogenic transcription factor stimulates proliferation and growth by activating thousands of target genes. Here we demonstrate that TFRC1 is a critical downstream target of c-Myc. Using in vitro and in vivo models of B-cell lymphoma, we show that TFRC1 expression is activated by c-Myc. Chromatin immunoprecipitation experiments reveal that c-Myc directly binds a conserved region of TFRC1. In light of these findings, we sought to determine whether TFRC1 is required for c-Myc-mediated cellular proliferation and cell size control. TFRC1 inhibition decreases cellular proliferation and results in G1 arrest without affecting cell size. Consistent with these findings, expression profiling reveals that TFRC1 depletion alters expression of genes that regulate the cell cycle. Furthermore, enforced TFRC1 expression confers a growth advantage to cells and significantly enhances the rate of c-Myc-mediated tumor formation in vivo. These findings provide a molecular basis for increased TFRC1 expression in human tumors, illuminate the role of TFRC1 in the c-Myc target gene network, and support strategies that target TFRC1 for cancer therapy.
Residual disease at the end of induction therapy as a predictor of relapse during therapy in childhood B-lineage acute lymphoblastic leukemia.

PURPOSE More than 95% of children with B-lineage acute lymphoblastic leukemia (ALL) achieve a clinical remission after the induction phase of chemotherapy (first 28 days) as evaluated by morphologic criteria. However, relapse occurs in approximately 30% of these children. The objective of this study was to determine whether the outcome of patients in clinical remission at the end of induction therapy could be predicted using a highly sensitive method to detect residual disease. PATIENTS AND METHODS All children diagnosed with B-lineage ALL at the Children's Hospital of Philadelphia during a 2-year period were eligible. The extent of residual leukemia was quantitated in remission marrow samples obtained at the end of induction therapy in 44 children using a phage clonogenic assay in association with complementarity-determining-region 3 (CDR3)-polymerase chain reaction (PCR). RESULTS Residual disease was a significant predictor of outcome independent of WBC count, age, or sex. The estimated relapse-free survival (RFS) during therapy was 50.4% (+/- 12.6%) for patients with high residual disease (> or = 0.6% leukemia cells among total marrow B cells) versus 91.9% (+/- 5.5%) for those with lower levels (P < .002). There were no significant differences in off-treatment RFS between patients with high or low residual disease who completed therapy in continuous remission (P = .82). The overall estimated RFS was 32.3% (+/- 11.6%) for patients with high residual disease versus 62.6% (+/- 10.7%) for patients with lower levels of residual leukemia cells, with a median follow-up of 5.3 years for patients in continuous remission (P < .008). CONCLUSION PCR detection of high residual disease at the end of induction therapy identifies patients at increased risk for relapse during therapy.
Nanomagnetic Logic: Demonstration of directed signal flow for field-coupled computing devices

In Nanomagnetic Logic (NML), computing operations are performed by non-volatile, field-coupled nanomagnets. For information propagation in nanomagnetic wires between logic gates, directed signal flow has to be implemented in the field-coupled devices. In this paper we present the solution for directed information propagation in a wire realized in NML with perpendicular magnetization. For the first time, non-reciprocal signal flow is experimentally demonstrated for field-coupled nanomagnets and homogeneous clocking fields. Micromagnetic simulations are performed and field-coupled nanomagnets are fabricated by focused ion beam (FIB) lithography and ion beam etching. Partial irradiation with a FIB is investigated to tailor the switching behavior of the nanomagnets. Three coupled nano-magnets in a wire are measured to verify the simulation results. Non-reciprocal field-coupling of the nanomagnets is proven by experiments within a nanomagnetic wire.
Mitigation of Multipath Fading Effects to Improve Indoor RSSI Performance

Received signal strength indicator (RSSI) is not suitable for fine-grained indoor applications because of imprecise and unreliable readings caused by multipath fading. This paper presents a simple and robust mechanism to improve RSSI by mitigating multipath fading effects in an indoor environment. Signal analysis is provided to explain the rationale of this method. The proposed method provides instantaneous solution, thus it is compatible with time-series filters and can be cascaded as additional improvement. The contributions of this proposal are the ease of implementation and its excellent output performance. The results show that it is able to eliminate unwanted noisy components caused by multipath fading, and thus obtain more reliable and stable RSSI readings.
Signal diversification in Oecanthus tree crickets is shaped by energetic, morphometric, and acoustic trade‐offs

Physiology, physics, and ecological interactions can generate trade‐offs within species, but may also shape divergence among species. We tested whether signal divergence in Oecanthus tree crickets is shaped by acoustic, energetic, and behavioral trade‐offs. We found that species with faster pulse rates, produced by opening and closing wings up to twice as many times per second, did not have higher metabolic costs of calling. The relatively constant energetic cost across species is explained by trade‐offs between the duration and repetition rate of acoustic signals—species with fewer stridulatory teeth closed their wings more frequently such that the number of teeth struck per second of calling and the resulting duty cycle were relatively constant across species. Further trade‐offs were evident in relationships between signals and body size. Calling was relatively inexpensive for small males, permitting them to call for much of the night, but at low amplitude. Large males produced much louder calls, reaching up to four times more area, but the energetic costs increased substantially with increasing size and the time spent calling dropped to only 20% of the night. These trade‐offs indicate that the trait combinations that arise in these species represent a limited subset of conceivable trait combinations.