Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of Gabapentin and Baclofen on Histology Study in Neuropathic Pain

Neuropathic pain resulted from injury to nerves is often resistant to current treatments and can seriously cause chronic pain if no appropriate treatment is given. This study was designed to prove the effectiveness of gabapentin and baclofen in increasing latency time toward thermal stimulus and recovering the morphology of dorsal horn of spinal cord in neuropathic-induced chronic pain. Forty mice were divided into 8 groups i.e sham, negative control, gabapentin at three different doses (10, 30, 100 nmol) and baclofen at three different doses (1, 10, 30 nmol). Neuropathic condition was induced by ligation of sciatic nerve with Partial Sciatic Nerve Ligation (PSNL) method. Gabapentin and baclofen were administrated intrathecally once a day for seven days, a week after neuropathic induction. Latency time toward thermal stimulus was measured on days 0, 1, 3, 5, 7, 8, 10, 12 and 14 after induction. Histology of the dorsal horn of spinal cord tissue was examined by haematoxylline-eosin staining. The results showed that intrathecal injection of gabapentin and baclofen significantly increased latency time of mice toward thermal stimulus compared with negative control. Gabapentin and baclofen are effective as treatment for neuropathic pain. They can also help the recovery process of the histology in dorsal horn in neuropathic pain. Keywords: Baclofen, dorsal horn, gabapentin, neuropathic pain, PSNL Efek Gabapentin dan Baclofen terhadap Studi Histologi pada Nyeri Neuropati Nyeri neuropati berasal dari luka pada saraf yang umumnya sulit diterapi sehingga menyebabkan nyeri kronik bila tanpa managemen terapi yang tepat. Tujuan penelitian ini adalah membuktikan efektivitas gabapentin dan baclofen dalam meningkatkan waktu ketahanan terhadap panas dan memperbaiki morfologi dorsal horn dari spinal cord pada keadaan nyeri kronik yang disebabkan neuropati. Empat puluh mencit terbagi ke dalam delapan kelompok, yaitu sham, kontrol negatif, gabapentin (dosis 10, 30 dan 100 nmol) serta baclofen (dosis 1, 10 dan 30 nmol). Nyeri neuropati diinduksi menggunakan metode Partial Sciatic Nerve Ligation (PSNL). Gabapentin dan baclofen diberikan secara intratekal satu kali sehari selama tujuh hari pada satu minggu setelah induksi nyeri neuropati. Waktu ketahanan terhadap stimulus panas diamati pada hari ke-0, 1, 3, 5, 7, 8, 10, 12, dan 14 setelah induksi. Histologi dorsal horn dari spinal cord mencit diamati menggunakan pewarnaan haematoxylline-eosin. Injeksi intratekal gabapentin dan baclofen meningkatkan waktu ketahanan terhadap stimulus panas secara signifikan dibandingkan kontrol negatif. Gabapentin dan baclofen efektif sebagai terapi nyeri neuropati. Keduanya juga dapat memperbaiki histologi dorsal horn pada kondisi nyeri neuropati. Kata kunci: Baclofen, dorsal horn, gabapentin, nyeri neuropati, PSNL
Exploring distributed leadership: Solving disagreements and negotiating consensus in a ‘leaderless’ team

This article explores how leadership is done in a ‘leaderless’ team. Drawing on a corpus of more than 120 hours of audio-recorded meetings of different interdisciplinary research groups and using a discourse analytic framework and tools, we examine how leadership is enacted in a team that does not have an assigned leader or chair. Our specific focus is the discursive processes through which team members conjointly solve disagreements and negotiate consensus – which are two activities associated with leadership. More specifically, we analyse how meaning is collaboratively constructed and how team members arrive at a solution in those instances where there is some kind of disagreement, or even conflict, among team members. This discourse analytic study thus contributes to leadership research in two ways: i) by exploring some of the discursive processes through which leadership is actually performed in a ‘leaderless team’; and ii) by looking at a largely under-researched leadership constellation, namely distributed leadership. We thereby illustrate some of the benefits that discourse analytical approaches offer to an understanding of the specific processes that are involved in the complexities of leadership performance.
General aspects of plant thioredoxins

Chloroplast is the organelle for photosynthesis in eukaryotic cells. In it the presence of a light-dependent ferredoxin/thioredoxin system (FTS) and a NADPH-dependent thioredoxin reductase C (NTRC), have been implicated in plant defense response and at the same time constitute important redox mechanism to provide reducing power to thioredoxins. This organelle also has a critical role in plant innate immunity against pathogen infection, where thioredoxins are the major responsible of to maintain proteins in their reduced state. The present work present a review of the scientific literature about some important aspects of plant thioredoxins.
Financing high-potential entrepreneurship

Entrepreneurship is essential to job creation and to productivity growth and therefore is an important matter for government policy. However, policymakers face a difficult challenge because successful growth for a few firms—which cannot easily be identified in advance—is accompanied by widespread failure for most other new firms. Predicting which firms will fail and which will succeed is nearly impossible. Instead of futilely trying to pick winners, governments can play a useful role in facilitating the growth of the most promising firms by setting the conditions for efficient trial-and-error experimentation across firms.
Tax Planning of R&D Intensive Multinationals

The allocation of management and control in the business decision process finds expression in the coordination intensity between agents in the firm. We develop and test a theory, based on the organizational design literature, for the intensity in which the tax department strives to coordinate with managers from other business units in order to intervene in investment decisions. Our theoretical considerations predict that R&D intensity is an important determinant of the tax department's role. Using data from a confidential survey taken in 2012 of top financial and tax managers of very large multinational companies, representing 8% of business R&D spending in the OECD, we indeed find supporting evidence that in R&D intensive multinational firms the tax department operates more as a controller than as a manager. In particular, tax departments of R&D intensive firms make less tax planning effort, are less ambitious to minimize the tax burden of the firm, are later involved in the decision-making process of a new investment project, but are more likely to have a veto right in the decision on a new investment project as compared to less R&D intensive firms. Conditional on R&D intensity, however, the level of intangible assets in the firm is associated with more tax planning efforts and ambitions. Our results are statistically significant and robust towards several sensitivity checks.
Simposium Nasional Akuntansi XV

During Asian financial crisis in 1997, some Indonesian public listed companies suffered by decreasing firm value and poor performance. The dominant factors that contributed to Asian financial crisis are poor corporate governance and lack of transparency. As attempt to improve corporate governance practice of Indonesian corporation, some reforms have been conducted by Indonesian regulatory authorities such as issued the code of good corporate governance with the objective to maximize shareholder and firm value by enhancing transparency, accountability, reliability, responsibility, and fairness. This study examined the relationship between those corporate governance attributes and corporate transparency of indonesian public listed companies By exploring the purposive sampling method, 88 companies were selected as the sample of this study. The finding of this study showed that board size and proportion of independent member on board positively affect corporate transparency. It means the corporate transparency will increase since the companies have large board and higher proportion of independent member on boards. In contrast, the proportion of board of directors who have family relationship is negatively associated with corporate transparency. It implies that family boards tend to advise management to disclose less information to public (less transparent) since they can get the informational benefit by transferring that information to their family. Meanwhile, the influence of family ownership, institutional ownership, management ownership, and foreign ownership on corporate transparency was not be supported by this study.
Effet de l'incorporation des protéines du lactosérum dénaturées et microparticulées dans le cheddar jeune

EtTect of incorporation of denatured and microparticulated whey protein in young Cheddar cheese. Two whey protein concentrates (WPC) heat-denatured at pH 4.2 (WPC 4.2) and at pH 6.7 (WPC 6.7) and microparticulated were used for the production of Cheddar cheese. Three micro-productions of Cheddar were made in triplicate: one with a control milk and the other two with milks in which the WPC 4.2 and WPC 6.7 ingredients were respectively added. The total amount of proteins was increased by 0.5 kgflOO kg of milk (0.5%). The expe- rimental cheeses had a significant higher yield, i.e., 4.3% with WPC 4.2 and 5.2% with WPC 6.7, than the control cheese, at a 37% constant moisture. Cheeses manufactured under these procedures were lower in fat and had a higher moisture content than the control chee se. Electronic micro- scopy shows that the control cheese had a more compact structure than the experimental cheeses. © InralElsevier, Paris. denaturation / whey protein / microfluidization / cheese yield
Impact of Spirituality and Political Skills on Transformational Leadership

The impact of spirituality and political skills on transformational leadership was studied using a 2 x 2 experimental design. Spirituality was operationalized as oneness, keeping in mind the context of the Indian culture. The sample consisted of 81 employees working in a public sector services organization in India. Results of analysis of variance show that transformational leadership is enhanced by spirituality but not by political skills. However, when used in combination with political skills, the impact of spirituality on transformational leadership is significantly lowered. This is perhaps because human beings are essentially spiritual in nature and not what the organizational context demands from them as political beings. Hence, this paper focuses on the essentialness of people to behave in ways not in basic contradiction with their fundamental nature if they wish to enhance their transformational leadership.
Intumescent silicone-based coatings for the fire protection of carbon fiber reinforced composites

The application of carbon fiber reinforced polymer (CFRP) in aircraft structure has introduced potential fire threats and fire protection must be provided. In this paper, intumescent silicone based-coatings (low and high intumescing coatings) are evaluated on CFRP using a bench developed in the laboratory mimicking a jet fuel fire occurring at high heat flux (200 kW/m2). It is shown the development of large intumescence (high intumescing coating) associated with appropriate thermal properties of the coating (heat conductivity measured as low as 0.3 W/m.K) provides efficient protection for the CFRP at the jet fire test. On the other hand, the formation of cohesive ceramic (low intumescing coating) with low heat conductivity (constant heat conductivity as a function of temperature of 0.35 W/m.K) also provides protection but its efficiency is lower than that of intumescent char. It is evidenced that intumescent silicone-based coatings are materials of choice for protecting CFRP in the case of jet fuel fire.
Personal, physical and socioeconomic factors affecting farmers' adoption of land consolidation.

Ownership of agricultural land is very fragmented in Turkey, as is the case in countries within central Europe. This prevents agricultural efficiency from reaching desired levels. Land consolidation involves redistributing land ownership so that individual farmers own fewer, larger, more compact and more contiguous land parcels. In Turkey, generally voluntary land consolidation projects are performed, while some financial limitations and political conditions prevent land consolidation reach to its desired level. For this reason, only 2.2% of the agricultural areas have been consolidated so far. Ideally, farmers adopt consolidation and are pleased by its results; this helps maintain the sustainability of the land structure formed by consolidation and accelerate acceptance of consolidation in other areas. In this study, the factors that are effective on farmers’ adopting land consolidation and their contentment were investigated. For this purpose, the results of the survey carried out in the selected villages within the Bursa- Karacabey plain were assessed using a logit model. According to the results obtained from this consolidation study, the criteria farmers value are the utilization of the irrigation system, reduction of inter-farmer conflicts, shaping parcels into a form proper for mechanized agriculture, and forming parcels of large dimensions by consolidating parcels. A higher level of contentment was observed among the farmers who were provided with above mentioned factors. Additional key words: evaluation, land fragmentation, land re-allotment, rural development.
ANTIOXIDANT ACTIVITY AND BIOGENIC SYNTHESIS OF SELENIUM NANOPARTICLES USING THE LEAF EXTRACT OF ALOE VERA

Objective: The objective of this present study were to the biogenic synthesis of selenium nanoparticles using Aloe vera extract and check it’s antioxidant potential by ABTS, DPPH and FRAP assays. Methods: In this study we investigated the clove of Aloe vera , which is used for the synthesis of selenium nanoparticles were characterized by using UV-Visible (UV-VIS) spectrophotometer, Transmission electron microscopy (TEM), Fourier transform spectroscopy (FTIR) and Energy dispersive X-Ray spectroscopy (EDAX) and ABTS, DPPH and FRAP assays for checked it’s antioxidant potential. Results: The present study was carried out to synthesis of Selenium nanoparticles using extract of Aloe vera . UV-Vis Spectra at 350 nm with Aloe vera extract and observed as hollow and spherical particles in size ranging 7-48 nm which is found more stable more than two months. EDAX analysis was carried out to check the presoak of Selenium in nanoparticles. Results of EDAX, confirmed its present. TEM and SEAD represented addition evidence of formation of nanoparticles whereas SEAD indicates the particles were crystalline in nature. FT-IR analysis was carried out to identify the possible bio molecules and Aloe vera extract-metal ions interaction responsible for formation and stabilization of selenium nanoparticles. FRAP, ABTS and DPPH assay results sequester that Selenium nanoparticles prepared using Aloe vera extract possess more activity than extract alone. Conclusion: The bio molecules of Aloe vera extract acted as stabilizing as well as capping agent leading to the formation of Selenium nanoparticles. Selenite has been proven to have antioxidant activity and is being used as chemoprevention agent in cancer diagnosis but same time it is toxic also. Elemental Selenium i.e. Selenium nanoparticles are less toxic form of selenium.
Modern regularization methods for inverse problems

Regularization methods are a key tool in the solution of inverse problems. They are used to introduce prior knowledge and allow a robust approximation of ill-posed (pseudo-) inverses. In the last two decades interest has shifted from linear to nonlinear regularization methods, even for linear inverse problems. The aim of this paper is to provide a reasonably comprehensive overview of this shift towards modern nonlinear regularization methods, including their analysis, applications and issues for future research. In particular we will discuss variational methods and techniques derived from them, since they have attracted much recent interest and link to other fields, such as image processing and compressed sensing. We further point to developments related to statistical inverse problems, multiscale decompositions and learning theory.
EMOTION REGULATION AND ACADEMIC PERFORMANCE AMONG IIUM STUDENTS: A PRELIMINARY STUDY

Emotion regulation and academic performance are two important domains in achieving students’ life’s goals and objectives. It is crucial for students to have the right attitude and be fortified with effective emotion regulation strategies to handle the difficulties of daily life. Thus, a study to investigate the relationship between emotion regulations strategies, namely cognitive reappraisal and expressive suppression, and academic performance was carried out. Participants of the study comprised of 127 Psychology students, between the age of 21 to 25 years old, from international Islamic University Malaysia. A survey adapted from Emotion Regulation Questionnaires (ERQ) by Gross (2011) was distributed to the participants.Academic performance measures was derived from demographic background and students’ CGPA. Results revealed that there are different findings between the two emotion regulation strategies. This study found there is a significant relationship between Expressive Suppression and CGPA ; however, no significant relationship existed between Cognitive reappraisal and CGPA. Regression model revealed that both cognitive reappraisal and expressive suppression did not predict students’ academic performance.
The growth of Finnish software companies in 2008-2011 : empirical investigation of financial ratios as the determinants of growth

The purpose of this study is to examine the relation of growth and the financial ratios of a company. The theoretical portion of the study focuses on the concept of growth in entrepreneurship theory. The empirical portion consists of examination of the financial ratios of 162 Finnish software companies in 2008-2011 by means of quantitative analysis methods. Statistical analysis methods, including analysis of variance, correlation and regression analysis, are used in the analysis. The objective of the study is to reveal how growth affects the financial ratios of a company and which ratios can be used to predict growth. The effects of companies’ age, geographical location and industrial classification on their financial ratios are also examined. The findings of this study reveal that the Finnish software industry inhabits a considerably high amount of growth companies. Younger companies were found to exhibit higher growth rates and absolute profitability than older ones. The findings suggest that a heightened level of cash is tied to the operations of companies exhibiting an especially slow or fast rate of growth. Companies exhibiting high growth were found to produce high levels of return on investment, but high growth was also found to put a company’s short term profitability and liquidity at risk. Only weak correlations were found between growth and the financial ratios of a company. The regression analysis revealed that a model combining 10 financial ratios may be used to predict the net sales growth of a company. Implications and future research proposals are provided.
Re-evaluation of Mature Seed-derived Callusing and Regeneration Potential of Nine Orchardgrass (Dactylis golomerata L.) Cultivars

A suitable callus induction and efficient regeneration protocol for orchardgrass (Dactylis golomerata L.) was developed. It consisted of 3 mg/l 2,4-D + 0.1 mg/l BA + 1 g/l CH + 300 mg/l L-proline + 40 mg/l L-cysteine + 30 g/l sucrose in MS showed the highest percentage of callus induction. Maltose exhibited better in regeneration than other types of carbon sources. Highest (71%) regeneration was obtained from N6 medium containing 1 mg/l 2,4-D + 3 mg/l BA + 1 g/l CH + 300 mg/l L-proline + 40 mg/l L-cysteine + 30 g/l maltose. Among the nine cultivars of orchardgrass (Dactylis golomerata L.), genotypic variation was observed in both callus induction and regeneration. Overall callus induction and regeneration rates were 23 - 73 and 17 - 71%, respectively.
Inducer Design to Avoid Cavitation Instabilities

Three inducers were designed to avoid cavitation instabilities. This was accomplished by avoiding the interaction of tip cavity with the leading edge of the next blade. The first one was designed with extremely larger leading edge sweep, the second and third ones were designed with smaller incidence angle by reducing the inlet blade angle or increasing the design flow rate, respectively. The inducer with larger design flow rate has larger outlet blade angle to obtain sufficient pressure rise. The inducer with larger sweep could suppress the cavitation instabilities in higher flow rates more than 95% of design flow coefficient, owing to weaker tip leakage vortex cavity with stronger disturbance by backflow vortices. The inducer with larger outlet blade angle could avoid the cavitation instabilities at higher flow rates, owing to the extension of the tip cavity along the suction surface of the blade. The inducer with smaller inlet blade angle could avoid the cavitation instabilities at higher flow rates, owing to the occurrence of the cavity first in the blade passage and its extension upstream. The cavity shape and suction performance were reasonably simulated by three dimensional CFD computations under the steady cavitating condition, except for the backflow vortex cavity. The difference in the growth of cavity for each inducer is explained from the difference of the pressure distribution on the suction side of the blades.
Laptops and Fourth-Grade Literacy: Assisting the Jump over the Fourth-Grade Slump.

School districts throughout the country are considering how to best integrate technology into instruction. There has been a movement in many districts toward one-to-one laptop instruction, in which all students are provided a laptop computer, but there is concern that these programs may not yield sufficiently improved learning outcomes to justify their substantial cost. And while there has been a great deal of research on the use of laptops in schools, there is little quantitative research systematically investigating the impact of laptop use on test outcomes, and none among students at the fourth-to-fifth grade levels. This study investigated whether a one-to-one laptop program could help improve English language arts (ELA) test scores of upper elementary students, a group that often faces a slowdown of literacy development during the transition from learning to read to reading to learn known as the fourth-grade slump. We explore these questions by comparing changes in the ELA test scores of a group of students who entered a one-to-one laptop program in the fourth grade to a similar group of students in a traditional program in the same school district. After two years’ participation in the program, laptop students outperformed non-laptop students on changes in the ELA total score and in the three subtests that correspond most closely to frequent laptop use: writing strategies, literary response and analysis, and reading comprehension.