Miracle-dz/UniFAR-FTUs huggingface dataset:
Factors influencing pediatric nephrology trainee entry into the workforce.

BACKGROUND AND OBJECTIVES Emerging needs in pediatric nephrology (PN) have made the number of nephrologists entering the workforce of critical importance. This study aimed to discern factors that influence PN fellows to choose their career path and decide to enter the PN workforce. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS A survey was sent to the American Society of Pediatric Nephrology list of PN fellows (n = 103) in 2008. The 57 fellows (55%) who completed the survey were representative of the group. RESULTS The majority decided on a career in PN as senior residents, most commonly due to their interest in renal physiology and academics. They felt residents chose other fields due to lack of interest/exposure to PN, financial constraints, and perceived PN workload. Fellows identified workload and their perception of faculty dissatisfaction as important concerns with PN. None of the respondents planned to leave fellowship, but 21% have considered this. Twenty-eight percent knew a PN fellow who resigned, thought to be due to workload, personal conflicts, and perceived faculty dissatisfaction. CONCLUSIONS Exposing residents to PN earlier in training and emphasizing positive features may create greater interest in PN. PN programs should be cognizant of workload and the influence of faculty dissatisfaction. Ongoing evaluation of PN fellow perceptions can assist in efforts to enhance recruitment and retention.
On and O ff Contract Remedies ∗

A party dissatisfied with the contractual performance of a counterparty is typically able to pursue a variety of legal recourses. Within this apparent variety lurk two fundamental alternatives. The aggrieved party may (i) “affirm” the contract and seek money damages or specific performance; or (ii) “disaffirm” the contract with the remedy of rescission and restitution. This simple dichotomy of contract remedies applies broadly in both common law and civil law practice. We show here that this remedial regime allows parties to write simple contracts that induce first-best cooperative investments.
The relationship between right ventricular pacing and atrial fibrillation burden and disease progression in patients with paroxysmal atrial fibrillation: the long-MinVPACE study.

AIMS In patients requiring permanent pacemaker implantation for sinus node disease (SND) or atrioventricular (AV) block, right ventricular (RV) pacing has been demonstrated to increase the risk of developing atrial fibrillation (AF). The effects of RV pacing in patients with paroxysmal AF are less well defined. Short- and medium-term studies have suggested no significant correlation between RV pacing and atrial fibrillation burden (AFB) measurement; we sought to assess for an effect in the long-term. METHODS AND RESULTS Sixty-six patients were randomized to receive either conventional dual chamber pacing (DDDR, n = 33), or dual chamber minimal ventricular pacing (MinVP, n = 33), for a period of at least 1 year. Patients were reviewed every 6 months and all pacemaker data were downloaded. The primary outcome measures were device-derived AFB and progression to persistent AF. The mean duration of study follow-up was 1.4 ± 0.6 years. Mean ventricular pacing was less in the MinVP cohort compared with the DDDR cohort (5.8 vs. 74.0%, P < 0.001). At follow-up, the device-derived AFB was significantly lower in the MinVP cohort when compared with the DDDR cohort (12.8 ± 15.3% vs. DDDR 47.6 ± 42.2%, P < 0.001). Kaplan-Meier estimates of time to onset of persistent AF showed significant reductions in the rates of persistent AF for MinVP pacing (9%) when compared with conventional DDDR pacing (42%), P = 0.004. CONCLUSION Right ventricular pacing induces increased AFB in patients with paroxysmal AF in the long term. Dual chamber MinVP algorithms result in reduced AFB and reduced disease progression from paroxysmal to persistent AF in the long term.
Do Economists Play Well with Others? Experimental Evidence on the Relationship Between Economics Education and Pro-Social Behavior

Does an economics education affect an individual's behavior? It is unclear whether differences in behavior are due to the education or whether those who choose to study economics are different. This issue is addressed using experimental evidence from the Trust Game where trusting and reciprocating behaviors can be measured. First, it is shown that economics students provide greater trusting investments and reciprocate more. Accounting for the selection effect, these effects are explained by those who choose to study economics and not directly from the education being provided. Thus, economists play well with others and these social preferences are not taught in the classroom.
Waixenicin A Inhibits Cell Proliferation through Magnesium-dependent Block of Transient Receptor Potential Melastatin 7 (TRPM7) Channels*

Background: TRPM7 channels are key regulators of cell growth and proliferation. Results: A natural compound from a Hawaiian soft coral blocks TRPM7 currents and inhibits proliferation. Conclusion: Waixenicin A represents the first potent and relatively specific inhibitor of TRPM7 ion channels. Significance: Waixenicin A or structural analogs may have cancer-specific therapeutic potential. Transient receptor potential melastatin 7 (TRPM7) channels represent the major magnesium-uptake mechanism in mammalian cells and are key regulators of cell growth and proliferation. They are expressed abundantly in a variety of human carcinoma cells controlling survival, growth, and migration. These characteristics are the basis for recent interest in the channel as a target for cancer therapeutics. We screened a chemical library of marine organism-derived extracts and identified waixenicin A from the soft coral Sarcothelia edmondsoni as a strong inhibitor of overexpressed and native TRPM7. Waixenicin A activity was cytosolic and potentiated by intracellular free magnesium (Mg2+) concentration. Mutating a Mg2+ binding site on the TRPM7 kinase domain reduced the potency of the compound, whereas kinase deletion enhanced its efficacy independent of Mg2+. Waixenicin A failed to inhibit the closely homologous TRPM6 channel and did not significantly affect TRPM2, TRPM4, and Ca2+ release-activated Ca2+ current channels. Therefore, waixenicin A represents the first potent and relatively specific inhibitor of TRPM7 ion channels. Consistent with TRPM7 inhibition, the compound blocked cell proliferation in human Jurkat T-cells and rat basophilic leukemia cells. Based on the ability of the compound to inhibit cell proliferation through Mg2+-dependent block of TRPM7, waixenicin A, or structural analogs may have cancer-specific therapeutic potential, particularly because certain cancers accumulate cytosolic Mg2+.
Clinical outcomes of endovascular treatments for critical limb ischemia with chronic total occlusive lesions limited to below-the-knee arteries

Background Diabetes mellitus tends to have the greatest impact on the smaller vessels and contributes significantly to occlusive disease from the popliteal artery distally. Purpose To evaluate the clinical outcomes after a balloon angioplasty with or without stent placement in diabetic patients with critical limb ischemia (CLI) by chronic total occlusion (CTO) limited to below-the-knee (BTK) arteries. Material and Methods From August 2005, patients who presented CLI and CTO limited to the BTK arteries, and who underwent endovascular treatment, were included in this study. The primary endpoints evaluated were technical success, limb salvage, and primary patency. The secondary endpoints evaluated were 30-day access site, intervention site, and systemic complications. Patency and limb salvage were evaluated using the Kaplan-Meier method and compared using Fisher's exact test. Results The BTK endovascular treatment (EVT) was performed on 64 limbs. Technical success rate was 93.8% and limb salvage rate was 90.6%. Three of four limbs with technical failure and three of 60 limbs with technical success underwent BTK amputation and the comparison of these rates were significantly different (75% vs. 5%, P = 0.002). Primary patency rates for the limbs were 75% and 59.1% at 6-month and 12-month follow-up, respectively. Minor complications disappeared through the follow-up periods and there was no 30-day complication or systemic adverse events for the treated vessel. Conclusion Even though EVT for CLI in patients with diabetes and CTO in isolated BTK arteries does not have comparable primary patency, it can lead to a very high rate of limb salvage. This result can accentuate the importance of more blood flow to the foot by means of successful revascularization using EVT rather than long-term patency in CTO of isolated BTK arteries.
Forecasting of Multivariate Time Series via Complex Fuzzy Logic

Multivariate time series consist of sequential vector-valued observations of some phenomenon over time. Time series forecasting (for both univariate and multivariate case) is a well-known, high-value machine learning problem, in which the goal is to predict future observations of the time series based on prior ones. Several learning algorithms based on complex fuzzy logic have recently been shown to be very accurate and compact forecasting models. However, these models have only been tested on univariate and bivariate datasets. There has as yet been no investigation of more general multivariate datasets. We report on the extension of the adaptive neuro-complex-fuzzy inferential system learning architecture to the multivariate case. We investigate single-input-single-output, multiple-input-single-output, and multiple-input-multiple-output variations of the architecture, exploring their performance on four multivariate time series. We also explore modifications to the forward- and backward-pass computations in the architecture. We find that our best designs are superior to the published results on these datasets, and at least as accurate as kernel-based prediction algorithms.
The Therapeutic Efficacy of Environmental Enrichment and Methylphenidate Alone and in Combination after Controlled Cortical Impact Injury.

Environmental enrichment (EE) and methylphenidate (MPH) independently confer significant benefit to behavioral recovery after controlled cortical impact (CCI) injury. Given that combinational therapies may be more clinically translatable than monotherapies, the aim of the current study was to test the hypothesis that a combined treatment regimen of EE and MPH would provide greater therapeutic efficacy than either one alone. Anesthetized adult male rats received either a CCI of moderate severity or sham injury and were then randomly assigned to EE or standard (STD) housing where they received either intraperitoneal (ip) MPH (5 mg/kg) or vehicle (VEH; 1.0 mL/kg; ip) beginning 24 h after injury and once daily for 19 days. Motor and cognitive assessments were conducted on post-injury days 1-5 and 14-19, respectively. No differences were observed in sham controls regardless of treatments, and thus their data were pooled. The traumatic brain injury (TBI)+EE+VEH and TBI+EE+MPH groups exhibited enhanced beam balance and beam walk performance relative to the TBI+STD+VEH group (p < 0.05), but did not differ from one another (p > 0.05). No effect of MPH treatment alone was observed in either motor task. In contrast, MPH improved spatial learning and memory when presented alone and also when combined with EE relative to VEH-treated STD controls (p < 0.05). In addition, both EE groups performed significantly better than the TBI+STD+MPH group (p < 0.05), but did not differ from one another (p > 0.05). These data replicate previous findings that both EE and MPH confer cognitive benefits after TBI and extend the findings by revealing that combining EE and MPH does not produce effects greater than either treatment alone, which does not support the hypothesis. The lack of an additive effect may be because of the robustness of the EE.
An automatic thermal cycling based test platform for thermoelectric generator testing

Thermoelectric (TE) modules are solid-state devices that convert directly thermal energy in electrical energy. However, they can undergo performance degradation due to thermal cycling. In the present study, a control-based test platform that is capable to apply specific thermal cycling pattern at periodic intervals is presented in order to evaluate performance degradation that influence the TE module lifetime. Using this test platform, some parameters and the figure of merit ZT of a commercial TE module are measured before and after thermal cycling application. An important feature of the proposed platform is that the applied thermal cycling is bipolar, that is, it is possible to apply positive or negative temperature difference and, through this, performance degradation would be observed after only 548 thermal cycles much lower than previous works.
Lumbopelvic muscle activation patterns in adolescent fast bowlers

Abstract Introduction: Adolescent fast bowlers are prone to sustaining lumbar injuries. Numerous components have been identified as contributing factors; however, there is limited empirical evidence outlining how the muscles of the lumbopelvic region, which play a vital role in stabilising the spine, function during the bowling action and the influence of such activation on injuries in the fast bowler. Methods: Surface electromyography was utilised to measure the function of the lumbar erector spinae, lumbar multifidus, gluteus medius and gluteus maximus muscles bilaterally during the fast bowling action in a group of 35 cricket fast bowlers aged 12–16 years. Results: Two prominent periods of activation occurred in each of the muscles examined. The period of greatest mean activation in the erector spinae and multifidus occurred near back foot contact (BFC) and within the post-ball-release (BR) phase. The period of greatest mean activation for the gluteus medius and gluteus maximus occurred during phases of ipsilateral foot contact. Discussion: The greatest periods of muscle activation in the paraspinal and gluteal muscles occurred at times where vertical forces were high such as BFC, and in the phases near BR where substantial shear forces are present. Conclusion: The posterior muscles within the lumbopelvic region appear to play a prominent role during the bowling action, specifically when compressive and shear forces are high. Further research is required to substantiate these findings and establish the role of the lumbopelvic muscles in the aetiology of lumbar injury in the cricket fast bowler.
Projected changes in daily fire spread across Canada over the next century

In the face of climate change, predicting and understanding future fire regimes across Canada is a high priority for wildland fire research and management. Due in large part to the difficulties in obtaining future daily fire weather projections, one of the major challenges in predicting future fire activity is to estimate how much of the change in weather potential could translate into on-the-ground fire spread. As a result, past studies have used monthly, annual, or multi-decadal weather projections to predict future fires, thereby sacrificing information relevant to day-to-day fire spread. Using climate projections from the fifth phase of the Coupled Model Intercomparison Project (CMIP5), historical weather observations, MODIS fire detection data, and the national fire database of Canada, this study investigated potential changes in the number of active burning days of wildfires by relating ‘spread days’ to patterns of daily fire-conducive weather. Results suggest that climate change over the next century may have significant impacts on fire spread days in almost all parts of Canada’s forested landmass; the number of fire spread days could experience a 2-to-3-fold increase under a high CO2 forcing scenario in eastern Canada, and a greater than 50% increase in western Canada, where the fire potential is already high. The change in future fire spread is critical in understanding fire regime changes, but is also imminently relevant to fire management operations and in fire risk mitigation.
OXYGEN AND HYDROGEN ISOTOPES IN THE HYDROLOGIC CYCLE

Changes of the isotopic composition of water within the water cycle provide a recognizable signature, relating such water to the different phases of the cycle. The isotope fractionations that accompany the evaporation from the ocean and other surface waters and the reverse process of rain formation account for the most notable changes. As a result, meteoric waters are depleted in the heavy isotopic species of H and O relative to ocean waters, whereas waters in evaporative systems such as lakes, plants, and soilwaters are relatively enriched. During the passage through the aquifers, the isotope composition of water is essentially a conservative property at ambient temperatures, but at elevated temperatures, interaction with the rock matrix may perturb the isotope composition. These changes of the isotope composition in atmospheric waters, surface water, soil, and groundwaters, as well as in the biosphere, are applied in the characterization of hydrological system as well as indicators of paleo-climatological conditions in proxy materials in climatic archives, such as ice, lake sediments, or organic materials.
Comparison of Contrast Agents for Atherosclerosis Imaging Using Cultured Macrophages: FDG Versus Ultrasmall Superparamagnetic Iron Oxide

Various noninvasive imaging methods have been developed to evaluate atherosclerotic plaques. Among them, 18F-FDG PET and MR imaging with ultrasmall superparamagnetic iron oxide particles (USPIO) have been used to quantify plaque inflammation. Both methods are based on the efficient uptake of FDG and USPIO by macrophages in atherosclerotic lesions. Differently polarized macrophages have been reported to have different characteristics that are involved in the pathologic development of atherosclerosis. M1 polarized macrophages are considered the more proatherogenic phenotype than M2 polarized macrophages. However, little is known regarding the association between macrophage polarization and FDG or USPIO accumulation. In this study, we investigated intracellular FDG and USPIO accumulation in M1 and M2 polarized macrophages. Methods: THP-1 macrophages were differentiated into M1 and M2 polarized macrophages. Under optimal glucose conditions, we investigated the 3H-labeled FDG uptake in M1 and M2 polarized macrophages. We then investigated intracellular USPIO uptake by M1 and M2 macrophages. Results: We found that M1 polarization, compared with M2 polarization, results in increased intracellular accumulation of FDG. To elucidate the mechanism by which FDG was preferentially accumulated in M1 macrophages, we examined messenger RNA expressions of glucose transporters (GLUTs) and hexokinases, which have pivotal roles in glucose uptake, and glucose-6-phosphatase (G6Pase), which catalyzes the reverse reaction of hexokinase. In M1 macrophages, GLUT-1, GLUT-3, hexokinase 1, and hexokinase 2 were upregulated and G6Pase was downregulated. In contrast to FDG, M1 polarization resulted in decreased intracellular accumulation of USPIO. We found that scavenger receptor A and CD11b, which are involved in USPIO binding and uptake, were significantly downregulated by M1 polarization. Conclusion: Compared with M2, proatherogenic M1 macrophages preferentially accumulated FDG but not USPIO, suggesting that FDG PET is a useful method for the detection of proinflammatory M1 macrophages.
Does the Fama and French Five‐Factor Model Work Well in Japan?

In this study, we investigate whether the five-factor model by Fama and French (2015) explains well the pricing structure of stocks with long-run data for Japan. We conduct standard cross-section asset pricing tests and examine the additional explanatory power of the new Fama and French factors; robust-minus-weak profitability factor and conservative-minus-aggressive investment factor. We find that robust-minus-weak and the conservative-minus-aggressive factors are not statistically significant when we conduct generalized method of moments (GMM) tests with the Hansen–Jagannathan distance measure. Thus, we conclude that the original version of the Fama and French five-factor model is not the best benchmark pricing model for Japanese data during our sampling period from the year 1978 to the year 2014.
Physiological Response Properties of Cat Retinal Ganglion Cells Projecting to Suprachiasmatic Nucleus

The aim of this experiment was to characterize the physiological properties of cat retinal ganglion cells that project to the suprachiasmatic nucleus (SCN). Retrogradely labeled SCN-projecting ganglion cells were recorded extra-cellularly in vitro. For the first time, this study provides crucial information on visual response properties of ganglion cells in the entrainment circuitry. All recorded cells gave sustained responses (n = 9). Although most of the cells (n =8) had an “on” center receptive field, one cell showed “on-off” center receptive field properties. The range of receptive field sizes was 2 to 5 deg. For most of the cells tested, the spectral wavelength that evoked peak responses was 500 nm (3 out of 5 cells). All recorded cells (n = 9) preferred still or extremely slow-moving stimuli (3.3 deg/s). These results indicate that cat SCN-projecting cells receive inputs from conventional photoreceptors. The hypothesis that both conventional and cryptochromic photoreceptors are involved in transferring photic signals is discussed.
Evolution of tacrolimus blood levels and concentration‐dose ratios in patients who develop new onset diabetes mellitus after kidney transplantation

New onset diabetes mellitus (NODM) affects kidney transplantation outcome. Several risk factors, including immunosuppressive drug levels, are related with NODM development. This analysis evaluates the incidence and risk factors of NODM in kidney transplant patients receiving tacrolimus, taking into account 6‐month blood levels and concentration‐dose ratios (CDRs). Seventy‐six patients under tacrolimus therapy who received a cadaveric renal transplant in our centre and with graft survival higher than 1 year were included in the study. NODM was defined as two fasting plasma glucose values ≥126 mg/dl or symptoms of diabetes plus casual plasma glucose concentrations ≥200 mg/dl throughout the first year. We examined previously reported variables related with NODM development. The incidence of NODM at 12 months was 27.6%. Risk factors for NODM included older age, higher first tacrolimus level, higher body mass index and lower first year weight gain. In multivariate analysis, the first year occurrence of NODM was significantly determined by the first tacrolimus blood level >20 ng/ml and age older than 50 years. CDR remains significantly higher in NODM throughout the 6 months. Older age and a high first tacrolimus blood level are associated with the development of NODM during the first year after kidney transplantation. NODM patients show higher CDR during the first 6 months.