Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of Contrast-Induced Acute Kidney Injury After Percutaneous Coronary Intervention on Short- and Long-Term Outcomes: Pooled Analysis From the HORIZONS-AMI and ACUITY Trials

Background—Contrast-induced acute kidney injury (CI-AKI), defined as a serum creatinine increase ≥0.5 mg/dL or ≥25% within 72 hours after contrast exposure, is a common complication of procedures requiring contrast media and is associated with increased short- and long-term morbidity and mortality. Few studies describe the effects of CI-AKI in a large-scale acute coronary syndrome population, and the relationship between CI-AKI and bleeding events has not been extensively explored. We sought to evaluate the impact of CI-AKI after percutaneous coronary intervention in patients presenting with acute coronary syndrome. Methods and Results—We pooled patient-level data for 9512 patients from the percutaneous coronary intervention cohorts of the Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) and Acute Catheterization and Urgent Intervention Triage Strategy (ACUITY) multicenter randomized trials. Patients were classified according to CI-AKI development, and cardiovascular outcomes at 30 days and 1 year were compared between groups. A total of 1212 patients (12.7%) developed CI-AKI. Patients with CI-AKI were older, with a more extensive comorbidity profile than without CI-AKI. Multivariable analysis confirmed several previously identified predictors of CI-AKI, including diabetes mellitus, contrast volume, age, and baseline hemoglobin. Mortality rates were significantly higher in the CI-AKI group at 30 days (4.9% versus 0.7%; P<0.0001) and 1 year (9.8% versus 2.9%; P<0.0001), as were rates of 1-year myocardial infarction, definite/probable stent thrombosis, target lesion revascularization, and major adverse cardiac events. Major bleeding (13.8% versus 5.4%; hazard ratio, 2.64; 95% confidence interval, 2.21–3.15; P<0.0001) was also higher in patients with CI-AKI. After multivariable adjustment, results were unchanged. Conclusions—CI-AKI after percutaneous coronary intervention in patients presenting with acute coronary syndrome is independently associated with increased risk of short- and long-term ischemic and hemorrhagic events. Clinical Trial Registration—URL: http://www.clinicaltrials. gov. Unique identifiers: NCT00433966 (HORIZONS-AMI) and ACUITY (NCT00093158).
The Agility total ankle arthroplasty. Seven to sixteen-year follow-up.

BACKGROUND We previously reported the intermediate-term results with the early version of the Agility total ankle replacement, a unique design that takes advantage of arthrodesis of the tibiofibular syndesmosis for tibial component support. The purpose of this study was to report longer-term results of this procedure in the treatment of disabling ankle arthritis. METHODS We conducted an independent review of all Agility total ankle replacements performed by a single surgeon between 1984 and 1994. Follow-up evaluation consisted of completion of a validated ankle osteoarthritis scale and a short questionnaire and a review of the radiographs. All radiographs were evaluated for evidence of the development of progressive hindfoot arthritis, nonunion of the tibiofibular syndesmosis, progressive radiolucent lines, osteolysis, and component subsidence. RESULTS One hundred and thirty-two arthroplasties were performed in 126 patients. After a mean follow-up period of nine years, thirty-three patients (thirty-six implants) had died, fourteen patients (11%) had a revision of the implant or an ankle arthrodesis, and one had the leg amputated because of an unrelated cause. Of the remaining seventy-eight patients (eighty-one ankles), sixty-seven (sixty-nine ankles) were followed clinically. More than 90% of them reported that they had decreased pain and were satisfied with the outcome of the surgery. We found modest differences in a comparison of the pain and disability scores with those of age-matched controls. Of the 117 ankles that had been followed radiographically for a minimum of two years, twenty-two (19%) had progressive subtalar arthritis, seventeen (15%) had progressive talonavicular arthritis, and nine (8%) had a syndesmosis nonunion. Eighty-nine (76%) of the 117 ankles had some evidence of peri-implant radiolucency. CONCLUSIONS Arthrodesis of the tibiofibular syndesmosis impacts the radiographic and clinical outcomes with the Agility total ankle replacement. The relatively low rates of radiographic hindfoot arthritis and revision procedures at an average of nine years after the arthroplasty are encouraging. Agility total ankle replacement is a viable and durable option for the treatment of ankle arthritis in selected patients.
Loss of Rat Glomerular ATP Diphosphohydrolase Activity during Reperfusion Injury Is Associated with Oxidative Stress Reactions

Summary Endothelial cell ATP diphosphohydrolases or ATPDases degrade extracellular inflammatory mediators ATP and ADP, thus inhibiting the formation of platelet thrombi, but the modulation of these ecto-enzymes during vascular injury remains largely undetermined. Renal glomerular ATPDase levels were determined in the rat following ische-mia-reperfusion or systemic complement activation, by direct biochemical methods and histochemistry. Ischemia followed by reperfusion times over 30 min were associated with loss of glomerular ATPDase activity. Cobra Venom Factor (CVF) inhibited ATPDase activity and potentiated the deleterious effects of reperfusion. Treatment with either soluble complement receptor type 1 (sCRl), an inhibitor of complement activation, or antioxidants prior to the ischemia-reperfusion was largely protective. Expression of rat glomerular ATPDase activity appears susceptible to the inflammatory injury associated with systemic complement activation and ischemia/reperfusion processes. Oxidative stress could, at least in part, result in the loss of ATPDase activity and thus thrombotic consequences of vascular injury.
Temperature Dependence of Impact Ionization in Submicrometer Silicon Devices

Photomultiplication, initiated by both pure electron and pure hole injection, has been measured in submicrometer Si p+-i-n+ and n+-i-p+ diodes with intrinsic region thicknesses w between 0.1 and 0.8 mum, at temperatures between 15 and 420 K. A local analysis is used to extract the values of effective ionization coefficients. Values of bulk ionization coefficients, alpha and beta, are then deduced and parameterized in an extended form of Chynoweth's expression to cover their dependence on both electric field and temperature. Multiplication at various temperatures can be recovered from these bulk coefficients by using a simple dead space correction. beta falls faster with temperature than alpha so that the ionization coefficient ratio, k=beta/alpha, decreases with temperature. Decreasing w reduces this temperature sensitivity, which is weaker than in GaAs, possibly because of the softer ionization threshold in Si
Honor and grace in anthropology

List of illustrations Notes on contributors 1. Introduction J. G. Peristiany and Julian Pitt-Rivers 2. Royalty and ritual in the Middle Ages: coronation and funerary rites in France Catherine Lafages 3. The court surrounds the King: Louis XIV, the Palatine Princess, and Saint-Simon Emmanuel Leroy Ladurie 4. Rites as acts of institution Pierre Bourdieu 5. Religion, world views, social classes, and honor during the sixteenth and seventeenth centuries in Spain Julio Caro Baroja 6. The Sophron - a secular saint? Wisdom and the wise in a Cypriot community J. G. Peristiany 7. The Greek hero J. K. Campbell 8. Name, blood, and miracles: the claims to renown in traditional Sicily Maria Pia Di Bella 9. From the death of men to the peace of God: violence and peace-making in the Rif Raymond Jamous 10. Indarra: some reflections on a Basque concept Sandra Ott 11. Postscript: the place of grace in anthropology Julian Pitt-Rivers Index.
Very tight bounds for the capacity of MIMO correlated Rician fading channels

No systematic procedure for tightly bounding the average capacity of MIMO correlated Rician fading channels is available in the literature. The difficulty arises from the complicated non-central Wishart distribution of channel sample matrix, in addition to the involvement of a highly nonlinear log determinant operator in the conditional capacity expression. In this paper, we tackle the problem with arbitrary antenna correlation existing either at the transmitter or at the receiver, but allowing for the numbers of the transmit and receive antennas to be arbitrary. By introducing an exact determinant expansion and by finding the explicit expressions for the expected values of the determinant and log-determinant of the complex non-central Wishart-distributed matrix, we obtain a simple but very tight upper and lower bounds for the average channel capacity. Both bounds are simple, in closed form, easy to be used, and superior in tightness as evidenced by intensive numerical examples.
Epithelial relaxation mediated by the myosin phosphatase regulator Mypt1 is required for brain ventricle lumen expansion and hindbrain morphogenesis

We demonstrate that in the zebrafish hindbrain, cell shape, rhombomere morphogenesis and, unexpectedly, brain ventricle lumen expansion depend on the contractile state of the neuroepithelium. The hindbrain neural tube opens in a specific sequence, with initial separation along the midline at rhombomere boundaries, subsequent openings within rhombomeres and eventual coalescence of openings into the hindbrain ventricle lumen. A mutation in the myosin phosphatase regulator mypt1 results in a small ventricle due to impaired stretching of the surrounding neuroepithelium. Although initial hindbrain opening remains normal, mypt1 mutant rhombomeres do not undergo normal morphological progression. Three-dimensional reconstruction demonstrates cell shapes within rhombomeres and at rhombomere boundaries are abnormal in mypt1 mutants. Wild-type cell shape requires that surrounding cells are also wild type, whereas mutant cell shape is autonomously regulated. Supporting the requirement for regulation of myosin function during hindbrain morphogenesis, wild-type embryos show dynamic levels of phosphorylated myosin regulatory light chain (pMRLC). By contrast, mutants show continuously high pMRLC levels, with concentration of pMRLC and myosin II at the apical side of the epithelium, and myosin II and actin concentration at rhombomere boundaries. Brain ventricle lumen expansion, rhombomere morphology and cell shape are rescued by inhibition of myosin II function, indicating that each defect is a consequence of overactive myosin. We suggest that the epithelium must `relax', via activity of myosin phosphatase, to allow for normal hindbrain morphogenesis and expansion of the brain ventricular lumen. Epithelial relaxation might be a widespread strategy to facilitate tube inflation in many organs.
Screening of Microorganisms Producing Cold-Active Oxidoreductases to Be Applied in Enantioselective Alcohol Oxidation. An Antarctic Survey

Several microorganisms were isolated from soil/sediment samples of Antarctic Peninsula. The enrichment technique using (RS)-1-(phenyl)ethanol as a carbon source allowed us to isolate 232 psychrophile/psychrotroph microorganisms. We also evaluated the enzyme activity (oxidoreductases) for enantioselective oxidation reactions, by using derivatives of (RS)-1-(phenyl)ethanol as substrates. Among the studied microorganisms, 15 psychrophile/psychrotroph strains contain oxidoreductases that catalyze the (S)-enantiomer oxidation from racemic alcohols to their corresponding ketones. Among the identified microorganisms, Flavobacterium sp. and Arthrobacter sp. showed excellent enzymatic activity. These new bacteria strains were selected for optimization study, in which the (RS)-1-(4-methyl-phenyl)ethanol oxidation was evaluated in several reaction conditions. From these studies, it was observed that Flavobacterium sp. has an excellent enzymatic activity at 10 °C and Arthrobacter sp. at 15 and 25 °C. We have also determined the growth curves of these bacteria, and both strains showed optimum growth at 25 °C, indicating that these bacteria are psychrotroph.
Myosin Essential Light Chain Isoforms Modulate the Velocity of Shortening Propelled by Nonphosphorylated Cross-bridges*

The differential effects of essential light chain isoforms (LC17a and LC17b) on the mechanical properties of smooth muscle were determined by exchanging recombinant for endogenous LC17 in permeabilized smooth muscle treated with trifluoperazine (TFP). Co-precipitation with endogenous myosin heavy chain verified that 40–60% of endogenous LC17a could be exchanged for recombinant LC17aor LC17b. Upon addition of MgATP in Ca2+-free solution, recombinant LC17 exchange induced slow contractions unaccompanied by regulatory light chain (RLC) phosphorylation only in TFP-treated, but not in untreated, permeabilized smooth muscle; the shortening velocity and rate of force development were approximately 1.5 and 2 times faster, respectively, in response to LC17a than LC17b. Additional incubation with recombinant, thiophosphorylated RLC increased the shortening velocity, independent of the LC17 isoform exchanged. The LC17-induced contractions of TFP-treated muscles were abolished by prior addition of nonphosphorylated RLC. We suggest that LC17 stiffens the lever arm of myosin and, in the absence of regulation by RLC, permits cross-bridge cycling without requiring RLC phosphorylation. Our results are compatible with nonphosphorylated RLC acting as a repressor and with LC17isoforms modulating the MgADP affinity and, consequently, rate of cooperative cycling of nonphosphorylated cross-bridges.
In Situ Interpretation without Type Mismatches

Quantified DPs are assigned a semantic type ((e,t),t) in which they map properties, denotations of type (e,t), to truth values, denotations of type t. properties are functions from entities to truth values. Ss like (1) are problematic for them since the transitive verb offend has type (e,(e,t)), not the type for properties but rather that of functions from entities to properties. So on H&K’s analysis neither offend nor every linguist is interpreted as a function whose domain contains the denotation of the other, so their interpretative mechanisms “are stuck” (H&K p.179) and cannot assign an interpretation to offend every linguist. H&K adopt a Fregean solution to the problem by changing the syntax of (1) so that offend every linguist is not a logical constituent. Rather the syntactic object which is compositionally interpreted is (2), in which the DP every linguist has been moved:
Gene targets of antisense therapies in breast cancer

Advances in molecular and cell biology have led to further understanding of the mechanisms of malignant growth and metastasis in human breast cancer cells. Initiation and progression of breast cancer results from mutations and the abnormal expression of many genes that control cellular proliferation, differentiation, invasion, metastasis and sensitivity to therapy (chemotherapy and radiation therapy). Inhibition of host immunity also plays a role in breast cancer progression. Many genes have been selected as targets for antisense therapy, including HER-2/neu, PKA, TGF-α, EGFR, TGF-β, IGFIR, P12, MDM2, BRCA, Bcl-2, ER, VEGF, MDR, ferritin, transferrin receptor, IRE, C-fos, HSP27, C-myc, C-raf and metallothionein genes. The strategy behind antisense therapy is the development of specific therapeutic agents that aim to correct the mutations and abnormal expression of cellular genes in breast tumour cells by decreasing gene expression, inducing degradation of target mRNA and causing premature termination of transcription. Many in vitro and in vivo studies have investigated the therapeutic efficacy of oligonucleotides and antisense RNAs. These studies have demonstrated specific inhibition of tumour cell growth by antisense therapy and have shown synergistic inhibitory effects between antisense oligonucleotides or antisense RNA and conventional chemotherapeutic drugs used in the treatment of breast cancer. Antisense oligonucleotides have been modified to improve their ability to penetrate cells, bind to gene sequences and downregulate target gene function. Many delivery systems for antisense RNA and antisense oligonucleotides have been developed, including virus vectors (retrovirus, adenovirus and adeno-associate virus) and liposomes, to carry the antisense RNA or oligonucleotides through the cell membrane into the cytoplasm and nucleus of the tumour cells. However, in order to determine their feasibility antisense therapies need to be further investigated to determine their antitumour activity, pharmacokinetics and toxicity in breast cancer patients.
Cystoscopic removal of a urolith from a pet guinea pig

THE guinea pig ( Cavia porcelles ) is a domesticated monogastric herbivoroushystricomorph rodent originating from South America. Believed to have been domesticated as early as 5000 BC in the Andean region of South America, they were used as a food item, predominately during ceremonial meals ([
Convolutional neural networks for acoustic modeling of raw time signal in LVCSR

In this paper we continue to investigate how the deep neural network (DNN) based acoustic models for automatic speech recognition can be trained without hand-crafted feature extraction. Previously, we have shown that a simple fully connected feedforward DNN performs surprisingly well when trained directly on the raw time signal. The analysis of the weights revealed that the DNN has learned a kind of short-time time-frequency decomposition of the speech signal. In conventional feature extraction pipelines this is done manually by means of a filter bank that is shared between the neighboring analysis windows. Following this idea, we show that the performance gap between DNNs trained on spliced hand-crafted features and DNNs trained on raw time signal can be strongly reduced by introducing 1D-convolutional layers. Thus, the DNN is forced to learn a short-time filter bank shared over a longer time span. This also allows us to interpret the weights of the second convolutional layer in the same way as 2D patches learned on critical band energies by typical convolutional neural networks. The evaluation is performed on an English LVCSR task. Trained on the raw time signal, the convolutional layers allow to reduce the WER on the test set from 25.5% to 23.4%, compared to an MFCC based result of 22.1% using fully connected layers. Index Terms: acoustic modeling, raw time signal, convolutional neural networks
Psoriasis Vulgaris Caused by Ceramic Inserts Used in Total Hip Replacement

Background: Ceramics are inorganic nonmetallic materials and are used as bioinert components in joint replacement surgeries. Ceramics are known to be low allergenic. We experienced a ceramic-induced psoriasis. Objective: We report a first case of possible ceramic-induced psoriasis caused by a ceramic insert. Methods: A 55-year-old female received an implanted ceramic-on-ceramic total hip replacement for osteoarthritis of the right hip joint. Following surgery, she developed psoriatic lesions, which continued for 10 years. We suspected that psoriasis was caused by a ceramic insert and removed it surgically. Results: When the ceramic insert was replaced with a polyethylene-on-metal hip joint, the psoriatic lesions completely disappeared. Conclusion: The pathogenesis of psoriasis is still an enigma, although deregulation of nuclear factor κB signaling and resulting abnormal cytokine secretion are speculated to be involved. Ceramics may affect these signaling events and cause the onset of psoriasis. Renseignements de base: Les céramiques sont des matériaux non métalliques inorganiques et sont utilisées comme composants bio-inertes dans les arthroplasties. Les céramiques sont reconnues pour être peu allergisantes. Nous avons observé un psoriasis provoqué par la céramique. Objectif: Nous exposons un premier cas possible de psoriasis provoqué par la céramique causé par un implant en céramique. Méthodes: Une femme de 55 ans a reçu une prothèse céramique-sur-céramique implantée lors d'une arthroplastie totale de la hanche pour traiter l'arthrose de l'articulation de la hanche droite. Après la chirurgie, elle a développé des lésions psoriasiques dont la manifestation s'est poursuivie pendant 10 ans. Nous avons soupçonné que le psoriasis était causé par l'implant en céramique, et nous l'avons enlevé chirurgicalement. Résultats: Une fois l'implant en céramique remplacé par une prothèse articulaire en polyéthylène-sur-métal, les lésions psoriasiques ont disparu complètement. Conclusion: La pathogenèse du psoriasis demeure une énigme, bien qu'on suppose que la dérégulation de la voie de signalisation NF-κB et que la sécrétion anormale de cytokines résultante soient impliquées. Les céramiques peuvent affecter ces événements de signalisation et provoquer l'apparition du psoriasis.
Too few necropsies.

gratefully) lived through a clinical revolution which enabled us to pick up and lead normal lives. At the time of writing I am, so far as I know, fit and privileged to have benefited from the dedication of those hundreds of tuberculosis specialists who literally nursed us through all the experimental treatments which began the medical revolution in the 1950s and early 1960s. It is probably true that the public at large does not realise the vast change that has occurred. But the patients who survived will never forget it. NEVILLE TAYLOR
A model for autumn outbreaks of Legionnaires' disease associated with cooling towers, linked to system operation and size

Summary Cooling towers have been demonstrated to be amplifiers and disseminators of legionella, the causative organism of Legionnaires' disease. Community outbreaks associated with cooling towers have been reported with several common factors. Small towers (< 300 kW) have predominantly been implicated in outbreaks. Cooling tower-associated outbreaks are most frequent in autumn, and frequently implicated systems have been operated after a period of shutdown. This paper reports field study data relating system operation to legionella colonization of systems. Operating systems have been shown to be more frequently colonized by legionella than shutdown systems. In some cases operation of systems after periods of shutdown raised legionella concentrations from below detection limits to between 50 and 950 c.f. u. /ml within 10 min. These data and previously reported data relating to biofilm and sediment colonization of the systems, and community outbreaks of Legionnaires' disease, have been used to develop a model explaining the seasonal nature of outbreaks associated with irregularly operated, small cooling tower systems.
CONCEPTUALIZING SEGREGATION First

Occupational gender segregation – the tendency for women and men to work in different occupations – is an important feature of all societies, and particularly the wealthy industrialized ones. To understand this segregation, and to explain its signi cance, we need to distinguish between vertical segregation entailing inequality and horizontal segregation representing difference without inequality, with overall segregation being the resultant of these components. Three major theoretical approaches to understanding occupational gender segregation are examined: human capital/rational choice, patriarchy, and preference theories. All are found to be inadequate; they tend to confuse overall segregation with its vertical component, and each entails a number of other faults. It is generally assumed or implied that greater empowerment of women would reduce gender segregation. This is the reverse of what actually happens; in countries where the degree of women’s empowerment is greater, the level of gender segregation is also greater. An alternative theoretical approach based on processes of social reproduction is shown to be more useful.