Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparison of DSM‐III Personality Disorders in Recovered Depressed and Panic Disorder Patients

A previous report using non-DSM-III measures indicated that recovered panic disorder and recovered major depressive patients have similar personality traits. To replicate this finding on DSM-III measures, 57 recovered panic, 19 recovered depressed, and 40 normal subjects were compared on standardized DSM-III personality measures. Virtually no differences were found between recovered major depression and recovered panic disorder patients. However, these two groups did differ from normal subjects in that they were more socially insecure and dependent.
The Disabilities of Chronic Schizophrenia—their Nature and the Factors Contributing to their Development

Summary Five hundred and ten patients receiving long-term in-patient care for schizophrenia were examined in terms of their current mental state, cognitive functioning, neurological status and behavioural performance. The abnormalities of these areas of their present state were related to historical factors, personal details, the features of the illness at its worst and physical treatment received. Significant associations between the present state and historical factors were few and mainly concerned time and the features of the illness at its worst. Current abnormalities were not related to past physical treatment, but highly significant correlations were found between the impairments of the four areas of the present state. It is concluded that these impairments are likely to be an integral part of the disease.
Percutaneous coronary intervention versus coronary-artery bypass grafting for severe coronary artery disease.

BACKGROUND Percutaneous coronary intervention (PCI) involving drug-eluting stents is increasingly used to treat complex coronary artery disease, although coronary-artery bypass grafting (CABG) has been the treatment of choice historically. Our trial compared PCI and CABG for treating patients with previously untreated three-vessel or left main coronary artery disease (or both). METHODS We randomly assigned 1800 patients with three-vessel or left main coronary artery disease to undergo CABG or PCI (in a 1:1 ratio). For all these patients, the local cardiac surgeon and interventional cardiologist determined that equivalent anatomical revascularization could be achieved with either treatment. A noninferiority comparison of the two groups was performed for the primary end point--a major adverse cardiac or cerebrovascular event (i.e., death from any cause, stroke, myocardial infarction, or repeat revascularization) during the 12-month period after randomization. Patients for whom only one of the two treatment options would be beneficial, because of anatomical features or clinical conditions, were entered into a parallel, nested CABG or PCI registry. RESULTS Most of the preoperative characteristics were similar in the two groups. Rates of major adverse cardiac or cerebrovascular events at 12 months were significantly higher in the PCI group (17.8%, vs. 12.4% for CABG; P=0.002), in large part because of an increased rate of repeat revascularization (13.5% vs. 5.9%, P<0.001); as a result, the criterion for noninferiority was not met. At 12 months, the rates of death and myocardial infarction were similar between the two groups; stroke was significantly more likely to occur with CABG (2.2%, vs. 0.6% with PCI; P=0.003). CONCLUSIONS CABG remains the standard of care for patients with three-vessel or left main coronary artery disease, since the use of CABG, as compared with PCI, resulted in lower rates of the combined end point of major adverse cardiac or cerebrovascular events at 1 year. (ClinicalTrials.gov number, NCT00114972.)
Title : Stress and Burnout in Forensic Community Mental Health Nurses : an investigation of its causes and effects

The increasing development of forensic services has seen the numbers of Forensic Community Mental Health Nurses (FCMHNs) mushroom. Community mental health nursing (CMHNs) has been found to be a stressful occupation. FCMHNs have largely been ignored in research into occupational stress. The current study identified and surveyed all FCMHNs (n=104) in England and Wales who were attached to NHS Medium Secure Units using measures of occupational stress. A response rate of 76.9% was achieved. Findings from this study showed that a substantial portion (44.3%) of FCMHNs were experiencing high burnout in relation to emotional exhaustion. 31.2% of FCMHNs reached or exceeded the threshold for psychiatric caseness on one measure. Concerns of FCMHNs included “not having facilities in the community to refer patients on to” and “interruptions in the office”. Dealing with violent patients did not feature in the top ten stressors although dealing with suicidal patients did. As a group FCMHNs appear to feel supported by their managers and colleagues.
Orientation of the femoral component in surface arthroplasty of the hip. A biomechanical and clinical analysis.

BACKGROUND Although the orientation of the femoral component has been shown to influence the outcome of total hip replacement, its effect on the clinical outcome of surface arthroplasty has not been studied, to our knowledge. The purpose of this study was to examine the relationship between femoral component positioning and the outcome of a surface arthroplasty of the hip. METHODS We reviewed the results of ninety-four hybrid metal-on-metal surface arthroplasties in patients who were forty years old or younger at the time of the operation and were followed for a minimum of two years or until the prosthesis failed. Measurements of the hip reconstruction were made on the anteroposterior pelvic radiograph. The correlation between the orientation of the femoral component and the outcome of the arthroplasty was evaluated, as were stresses within the resurfaced femoral head as a function of the orientation of the femoral component. RESULTS The mean duration of follow-up was 4.2 years. Thirteen hips had an adverse outcome, defined as conversion to a total hip replacement, radiolucency of >1 mm in thickness adjacent to the femoral stem, or narrowing of the femoral neck of >10%. The mean femoral stem-shaft angle in the coronal plane was 138 degrees, with the hips that had an adverse outcome having a significantly lower mean angle than the rest of the cohort (133 degrees compared with 139 degrees, p = 0.03). Hips with an angle of <or=130 degrees had an increase in the relative risk of an adverse outcome by a factor of 6.1 (p < 0.004). In the entire cohort, stresses in the superior aspect of the resurfaced femoral head were substantially lower during slow walking than they were during fast walking (7.1 N/mm(2) compared with 14.2 N/mm(2)). CONCLUSIONS Optimizing the femoral stem-shaft angle toward a valgus orientation during the preparation of the femoral head is important when a hip is being reconstructed with a surface arthroplasty because the resurfaced hip transmits the load through a narrow critical zone in the femoral head-neck region and the valgus angulation may reduce these stresses.
Uses and risks of microblogging in organisational and educational settings

Purpose The paper aims to clarify the relationship between organisational and educational use of microblogging. Although enterprise and education are very different sectors of activity and have diverse research traditions, this review argues that there is a benefit to be derived from comparing research work across the two settings. Design/methodology/approach The paper conducted a thematic analysis of research literature on microblogging for the two fields. The collection comprised around 30 papers on enterprise microblogging ( EMB), defined as use of microblogging primarily with internal organisational audiences behind the firewall. Twenty-five research papers on microblogging in higher education ( MIHE) made up the rest of the corpus. A generic framework of uses and risks of microblogging was produced and it is the main contribution of the paper. Findings The comparison of the literature on microblogging in the two sectors has led to the development and evaluation of a generic framework, which graphically presents its use and risks. The paper has introduced some ideas about how microblogging is used and they are potentially useful for the other context, for instance, the concept of awareness from the organisational literature. While the organisational literature has a major focus on risk, this appreciation is far less developed in the educational context; increasing such an emphasis would improve employability. Research limitations/implications Most of the research on EMB to date has been about uses of microblogging in large organisations, often information technology based. Research on MIHE has been experiments on the effect of microblogging in learning and classroom activities. Therefore, there is room to expand research beyond these settings. Practical implications The developed framework can be a useful guide for other researchers to explore issues around microblogging in different settings, such as educators using microblogging for research or use in other contexts. It is helpful to researchers to see how different theoretical concepts and research methods might be deployed in another context. The framework might also be used for comparing other technologies apart from Web 2.0/microblogging. Originality/value The paper has been the first review that we are aware of that has concentrated on the uses and risks of microblogging technologies in these particular contexts, organisation and education. [ABSTRACT FROM AUTHOR]
Clinical Evaluation of Acuvue Contact Lenses with UV Blocking Characteristics

Background. In response to increasing scientific evidence which indicates that ultraviolet radiation (UVR) is a potential threat to ocular health, Acuvue contact lenses (Vistakon, Johnson & Johnson Vision Products Inc., Jacksonville, Florida) have been developed which incorporate an ultraviolet (UV) blocker within the lens polymer. Data are presented for the first clinical evaluation of Acuvue lenses with UV blocking characteristics. Method. A doublemasked, multicenter, prospective clinical trial involving 94 subjects was conducted. The study followed a randomized, parallel group design and consisted of 3 months of daily wear with two-weekly lens replacement. Two thirds of the subjects (61) wore the test lenses (Acuvue with UV blocker) and the remaining subjects (33) wore conventional Acuvue lenses (without UV blocker). Results. Biomicroscopic evaluations indicated that the performance of the test and control lenses was clinically similar. No clinically relevant differences between the test and control lenses were noted in the subjective assessments of vision, comfort, or handling. In addition, no differences were shown for surface deposition, lens durability, visual acuity, and subjective symptoms. Conclusion. The study findings indicate that the addition of a UV blocker to Acuvue contact lenses has been achieved without affecting daily wear clinical performance. Because there is increasing evidence to suggest that the ocular tissues may be damaged by UVR, it is prudent for eye care practitioners to prescribe contact lenses that offer the benefits of both regular replacement and UV protection.
Gravimetric determination of tannins and their correlations with chemical and protein precipitation methods

Abstract. A method for gravimetric determination of tannins based on binding with insoluble polyvinylpyrrolidone (PVP) is presented. The gravimetric method gives the absolute amount of tannins and avoids problems of standards associated with spectrophotometric methods. The method was applied to nine browse and tree leaves. The values obtained correlate significantly with tannins determined spectrophotometrically, protein precipitation capacities and protein precipitable phenotics. This method together with other tannin assays will be useful in nutritional studies. The present study also demonstrates the different behaviour of tannic acids from different commercial sources towards PVP suggesting the presence of different moieties in tannic acids from different commercial sources and even among batches from the same source thereby affecting the results obtained using the spectrophotometric methods. Use of well-defined tannic acid as a standard in spectrophotometric methods is suggested which will allow meaningful comparison of values obtained from different laboratories.
Photodynamic Therapy for Solid Tumor Therapy: No Longer Restricted by Hypoxia

Photodynamic therapy (PDT), a minimally invasive treatment modality for cancer, involving the formation of reactive oxygen species (ROS) and subsequently eradication of the tumorous cells, has received a great attention. However, its oxygen-dependent nature to certain degree limits PDT from achieving satisfactory outcomes in solid tumors because of the frequent hypoxia circumstances. To alleviate hypoxia, efforts have been made through diversified strategies, e.g., delivery of ecdemic oxygen and intracellular replenishment of oxygen during PDT. In this mini review, we further elaborate on the details of these strategies and corresponding mechanisms for better therapy efficacy.
Pricing Behaviour and the Response of Hours to Productivity Shocks

Recent contributions have suggested that technology shocks have a negative impact on hours, contrary to the prediction of standard flexible-price models of the business cycle. Some authors have interpreted this finding as evidence in favour of sticky-price models, while others have either extended flexible-price models or disputed the empirical finding itself. In this paper we estimate a variety of alternative TFP measures for a representative sample of Italian manufacturing firms and on average find a negative effect of productivity shocks on hours. Using the reported frequency of price reviews, we show that the contractionary effect is stronger for firms with more flexible prices. Price stickiness remains a crucial factor in the response of hours even if product storability or market power are allowed for. Our results hold under alternative assumptions for the stationarity of hours per capita.
Vibrio cholerae RND Family Efflux Systems Are Required for Antimicrobial Resistance, Optimal Virulence Factor Production, and Colonization of the Infant Mouse Small Intestine

ABSTRACT Vibrio cholerae is a gram-negative human intestinal pathogen that causes the diarrheal disease cholera. Humans acquire cholera by ingesting V. cholerae-contaminated food or water. Upon ingestion, V. cholerae encounters several barriers to colonization, including bile acid toxicity and antimicrobial products of the innate immune system. In many gram-negative bacteria, resistance to the antimicrobial effects of these products is mediated by RND (resistance-nodulation-division) family efflux systems. In this study we tested the hypothesis that the V. cholerae RND efflux systems are required for antimicrobial resistance and virulence. The six V. cholerae genes encoding RND efflux pumps were deleted from the genome of the O1 El Tor strain N16961, resulting in the generation of 14 independent RND deletion mutants, including one RND-null strain. Determination of the antimicrobial susceptibilities of the mutants revealed that the RND efflux systems were responsible for resistance to multiple antimicrobial compounds, including bile acids, antimicrobial peptides, and antibiotics. VexB (VC0164) was found to be the RND efflux pump primarily responsible for the resistance of V. cholerae to multiple antimicrobial compounds in vitro. In contrast, VexD (VC1757) and VexK (VC1673) encoded efflux pumps with detergent-specific substrate specificities that were redundant with VexB. A strain lacking VexB, VexD, and VexK was attenuated in the infant mouse model, and its virulence factor production was unaffected. In contrast, a V. cholerae RND-null strain produced significantly less cholera toxin and fewer toxin-coregulated pili than the wild type and was unable to colonize the infant mouse. The decreased virulence factor production in the RND-null strain was linked to reduced transcription of tcpP and toxT. Our findings show that the V. cholerae RND efflux systems are required for antimicrobial resistance, optimal virulence factor production, and colonization of the infant mouse.
STUDIES OF PPLO INFECTION

Extracts of five arginine-utilizing mycoplasmas inhibit PHA-induced lymphocyte mitosis, while extracts of five glucose-utilizing mycoplasmas do not. Evidence is presented supporting the view that the inhibitory factor is the enzyme arginine deiminase. This enzyme inhibits the reactions of human lymphocytes to antigens as well as PHA, and the secondary production of antibody by rabbit lymph node fragments in vitro. Addition of enzyme to the cells several days after the initial mitotic or antigenic stimulus reduces, but does not abolish, further cellular activity. The production of serum proteins by hepatoma cells is totally unaffected by the mycoplasmal extract. It is concluded that arginine is an essential amino acid for the small lymphocyte, but not for the transformed cell nor for a number of other cell types. Suggestive evidence has been obtained that other enzymes similarly affect lymphocyte reactions.
Radiographic, clinical, and prognostic features of complicated and uncomplicated community-acquired lobar pneumonia in children.

BACKGROUND AND PURPOSE The incidence of community-acquired lobar pneumonia in conjunction with either necrosis or empyema in children has rapidly increased in recent years. This study aimed to evaluate the radiographic, clinical, and predicted factors of complicated and uncomplicated lobar pneumonia in children. METHODS This retrospective study included 131 patients younger than 18 years of age with community-acquired lobar pneumonia treated between January 2002 and March 2005. Multiple logistic regression analysis was performed to demonstrate the risk factors of complicated lobar pneumonia. RESULTS The proportion of children with lobar pneumonia in children increased dramatically from 7% in 2002 to 19% in 2004. Analysis revealed the presence of elevated C-reactive protein level (>12 mg/dL) [odds ratio (OR), 3.51; 95% confidence interval (CI), 1.61-7.66], persistent fever for more than 1 week before admission (OR, 1.14; 95% CI, 1.04-1.26), and multilobar (> or =2 lobes) confluent lung opacity on chest radiographs (OR, 2.83; 95% CI, 1.27-6.33) were independent predictors of the occurrence of complicated lobar pneumonia. A progressive increase in the number of penicillin-non-susceptible Streptococcus pneumoniae isolates was found during the study period. Prolonged fever was a common clinical feature of hospitalized children with lobar pneumonia. Failure of consolidative pneumonia to respond to appropriate antibiotic treatment within 4.4 days was associated with the development of necrosis or empyema. CONCLUSIONS Complicated and uncomplicated lobar pneumonia are difficult to distinguish based on clinical symptoms at the time of admission. The presence of the above risk factors can help in the early diagnosis of complicated lobar pneumonia.
Analysis of dispersion characteristic of substrate integrated waveguide based on mode matching method

In this paper, β-ω of substrate integrated waveguide is studied. First, a unit cell of the whole structure is analyzed by mode matching technique. Then by applying Floquet theory into the solution process, dispersion characteristic of the periodic structure is obtained and effects of various parameters of the structure on the response are described. Finally, proposed method is validated by comparing our results with other published results and Ansoft's HFSS.
Epidemiology of Diaphyseal and Distal Femoral Fractures in Rochester, Minnesota, 1965–1984

Over the 20-year period from 1965 to 1984, 370 residents of Rochester, Minnesota experienced 402 femoral fractures exclusive of the hip, giving an overall incidence rate of 37.1 per 100,000 person-years (95% confidence interval, 33.4–40.8). Of these, 54 were subtrochanteric and 210 were diaphyseal, while 123 involved the distal femur and 15 were at unspecified femoral sites. Fifty-eight percent of these fractures were caused by severe trauma. The incidence of femoral fractures due to severe trauma was greatest in young patients, especially for diaphyseal fractures, and showed a male excess. One-third of the fractures were associated with moderate trauma and were responsible for the rising incidence rates with age at all three fracture sites. These increases were greater in women. Eighty percent of patients 35 years of age or older with fractures due to moderate trauma had prior evidence of generalized os-teopenia or a condition likely to cause localized osteopenia in the fractured femur. These data confirmed similar findings from Sweden, providing evidence for a relationship between osteoporosis and femoral fractures distal to the hip.
Radiobiological effects of altering dose rate in filter-free photon beams

To validate that altering radiotherapy dose rate through either changing pulse repetition frequency or instantaneous dose rate does not have an effect on cell survival, two human carcinoma and a hamster lung cell line were irradiated with various beam settings. Varian TrueBeam linac with a flattening filter free mode of operation was used for all experiments. The results obtained indicate that either method of changing dose rate has no effect on cell survival in the three cell lines studied. Filtered and filter free modes were also compared in treatments with protracted dose delivery which significantly increases overall treatment time. Cell survival indicated no difference between filter and filter free beam delivery in any of the protraction schemes. An increase in survival was seen in both modes upon protracting dose delivery to 15, 30 or 60 min rather than delivering acutely. Further, analysis of induced DNA double-strand breaks via the γH2AX assay showed no difference between filtered and unfiltered beams. The following study suggests that increasing dose rate is an acceptable manner of decreasing radiotherapy treatment time that does not have any detrimental effects on in vitro cell eradication.
Editorial: Can we afford to overlook hand hygiene again?

L'accès à l'eau potable et fiable et à l'assainissement, Objectif 7 du Millénaire pour le Développement, cible 7c, est essentiel pour la santé et le bien‐être et est reconnu comme un droit humain. L'hygiène offre de nombreux avantages pour la santé, liés à l'eau et à l'assainissement et pourtant elle est encore absente des Objectifs du Millénaire pour le Développement. En 2013, l'Assemblée Générale des Nations Unies se réunira pour convenir des objectifs et cibles de développement durable postérieurs à 2015. La santé ne devrait pas être mise à l’écart de ce processus.
Introduction to the special issue on memory-based language processing

Memory-based language processing (MBLP) views language processing as being based on the direct reuse of previous experience rather than on the use of rules or other structures extracted from that experience. In such a framework, language acquisition is modelled as the storage of examples in memory,and language processing as analogical or similarity-based reasoning. We briefly discuss the properties and origins of this family of techniques, and provide an overview of current approaches and issues.
Can hsp90α-Targeted siRNA Combined With TMZ Be a Future Therapy for Glioma?

ABSTRACT Hsp90α's vital role in cell cycle progression and apoptosis together with its presence in gliomas and absence in normal tissue, make it a credible target for cancer therapy. Three sets of dsRNA oligos designed to align different regions of the hsp90α sequence were used to downregulate hsp90α. SiRNA 1, 2, and 3 resulted in significant levels of silencing of hsp90α after 48 hr treatment (p < .0001). Concurrent treatment of the glioma cell line U87-MG with siRNA 1 and temozolomide (TMZ) resulted in a 13-fold reduction in the dose of TMZ required to achieve a similar effect if TMZ was used alone.