Miracle-dz/UniFAR-FTUs huggingface dataset:
Olfactory ensheathing cells (OECs) and the treatment of CNS injury: advantages and possible caveats

One of the main research strategies to improve treatment for spinal cord injury involves the use of cell transplantation. This review looks at the advantages and possible caveats of using glial cells from the olfactory system in transplant‐mediated repair. These glial cells, termed olfactory ensheathing cells (OECs), ensheath the axons of the olfactory receptor neurons. The primary olfactory system is an unusual tissue in that it can support neurogenesis throughout life. In addition, newly generated olfactory receptor neurons are able to grow into the CNS environment of the olfactory bulb tissue and reform synapses. It is thought that this unique regenerative property depends in part on the presence of OECs. OECs share some of the properties of both astrocytes and Schwann cells but appear to have advantages over these and other glial cells for CNS repair. In particular, OECs are less likely to induce hypertrophy of CNS astrocytes. As well as remyelinating demyelinated axons, OEC grafts appear to promote the restoration of functions lost following a spinal cord lesion. However, much of the evidence for this is based on behavioural tests, and the mechanisms that underlie their potential benefits in transplant‐mediated repair remain to be clarified.
Control of Nutrient-Sensitive Transcription Programs by the Unconventional Prefoldin URI

Prefoldins (PFDs) are members of a recently identified, small–molecular weight protein family able to assemble into molecular chaperone complexes. Here we describe an unusually large member of this family, termed URI, that forms complexes with other small–molecular weight PFDs and with RPB5, a shared subunit of all three RNA polymerases. Functional analysis of the yeast and human orthologs of URI revealed that both are targets of nutrient signaling and participate in gene expression controlled by the TOR kinase. Thus, URI is a component of a signaling pathway that coordinates nutrient availability with gene expression.
Body Posture as an Indicator of Workload in Mental Work

Objective: For this article, the relationships between body posture and workload for four mental tasks simulated on a computer were studied. Background: Human behaviors are observable during work and are related to human mental activities. A novel supplementary method, based on human behavior but not directly related to task execution, is proposed to assess the workload in mental work situations. Method: Body posture was quantitatively analyzed with the use of a video-based analysis system. The distance between a participant’s head and the display, the distance between the shoulder and the hip, and the trunk angle of the shoulder and the hip with respect to the gravitational field were calculated. Results: The various tasks affected the distance between the head and the display (p < .001) and the trunk angle (p < .001). The distance between the head and the display decreased with increasing workload (p = .007). Conclusion: These results indicate that body posture can be used as an indicator for overall workload assessment. Application: The proposed method of workload may be useful for real-time observations or the monitoring of mental states in mental work environments (e.g., rail traffic dispatching, air traffic control).
Corporate Governance, Innovation and Firm Age: Insights and New Evidence

This paper investigates the relationship between corporate governance (CG) and innovation according to firms’ age by combining insights from the recent strand of contributions analysing CG and innovation with the lifecycle literature. We find a negative relationship between CG and innovation which is stronger for young firms than for mature ones. The empirical analysis is carried out on a sample of firms drawn from the ISSR isk Metrics database and observed over the period 2003 -2008. The parametric methodology provides results that are consistent with the literature and supports the idea that mature firms are better off than young ones. We check for possible non-linearities by implementing a non-parametric analysis and suggest that the negative relationship between CG and innovation is mostly driven by higher values of CG.
Craniofacial morphology in prematurely born children.

OBJECTIVE To test the null hypothesis that there is no difference between the craniofacial morphology of prematurely born children and that of matched full-term born controls. MATERIALS AND METHODS White children 8 to 10 years of age, born at the University Hospitals of Lund and Malmö and living in the same part of Sweden, were included. One group consisted of 36 very preterm children, born during gestational weeks 29 to 32; the other group included 36 extremely preterm children, who were born before the 29th gestational week. Subjects were compared with a control group of 31 full-term children, who were matched for gender, age, nationality, and living area. One lateral head radiograph was taken for each child, and the cephalometric analysis included 15 angular and 11 linear variables. Also, the height, weight, and head circumference of each child were registered. RESULTS A significantly shorter anterior cranial base and a less convex skeletal profile were found among extremely preterm children, and significantly shorter maxillary length was noted in both extremely preterm and very preterm groups as compared with full-term children. The lower incisors were significantly more retroclined and retruded in the extremely preterm group compared with the very preterm group and the full-term control group. Extremely preterm children were significantly shorter, and both extremely preterm and very preterm children had significantly lower weight and smaller head circumference compared with full-term children. CONCLUSION The null hypothesis was rejected because several craniofacial parameters differed significantly between preterm and full-term born control children.
New methods of teaching and learning mathematics involved by GeoGebra

Archimedes drew his figures on beach sand, mud or ash on a floor or put on his body, previously anointed with oil; on his body the figures were drawn with nails. When the Roman general Marcellus conquered in 212 BC Siracusa in Sicily, the city of Archimedes, a Roman soldier came across this genius contemplating his drew circles on the sand. "Nolite turbare circulos meos! " (Do not break my circles) Archimedes told to the soldier, but this, irritated, stabbed him with the sword, killing him. Today the place of the geometric constructions is on dynamic platforms supported by specialized software. One of these platforms is GeoGebra software. As the inventor stated, GeoGebra is a dynamic mathematics software for all levels of education that joins arithmetic, geometry, algebra and calculus. It offers multiple representations of objects in its graphics, algebra, and spreadsheet views that are all dynamically linked. While other interactive software (e.g. Cabri Geometry, Geometer's Sketchpad) focus on dynamic manipulations of geometrical objects, the idea behind GeoGebra is to connect geometric, algebraic, and numeric representations in an interactive way. You can do constructions with points, vectors, lines, conic sections as well as functions and change them dynamically afterwards. Furthermore, GeoGebra allows you to directly enter and manipulate equations and coordinates. Thus you can easily plot functions, work with sliders to investigate parameters, find symbolic derivatives, and use powerful commands like Root or Sequence, (www.geogebra.org). Because some of us (teachers of different subjects), see the computers in terms of "IT specialist", producers of software and not as a user, we propose this ongoing project in order to bring the computer in the context of approaching successful teaching. We believe that the teacher, regardless of the specialty they teach, shouldn’t know what's in the magic box (called generic computer), but he’ll have to know that the magic box will help him to assist the student to learn, the route to knowledge becoming pleasant! This paper is an invitation to solve math problems in a natural didactic way using the GeoGebra platform.
A Study on the Magma Origin of the Changbai Mountain Volcano Based on Lithological Analysis

Changbai Mountain Volcano is a Cenozoic volcano in the northeastern part of the Asian continental plate. It is located about 1000 km away from the subduction trench, underlain by the stagnant western Pacific slab. The magma origin of the Changbai mountain volcano is obviously different from tranditional arc volcano. Occurrence of the partial melting due to dehydration of the deep stagnant Pacific slab is one of the most favorite explanations of the Changbai mountain volcano origin. However, the evidence is still lacking or deficient, especially the geological one. In our study in this paper Lithological analysis is implemented to determine the magma origin of the Changbai Mountain Volcano. According to the lithological analysis result, we present a geo-dynamic model of the magma origin of the Changbai Mountain Volcano.
Short-Term Clinical Benefit of Sirolimus-Eluting Stents Compared to Bare Metal Stents for Patients with Acute Myocardial Infarction

Sirolimus-eluting stents (SES) have been recently proven to reduce restenosis and reintervention compared with bare metal stents (BMS). However, the effectiveness of SES in acute myocardial infarction (AMI) remains uncertain. The aim of this study was to evaluate the efficacy of SES implantation in patients with AMI compared with that of BMS. From January 2003 to April 2004, angioplasty with SES was performed in 76 patients (82 lesions) with AMI and the result was compared with that of 106 patients (113 lesions) treated with BMS. The incidence of major adverse cardiac events (death, nonfatal myocardial infarction, and target lesion revascularization) and binary angiographic restenosis were evaluated. Antiplatelet therapies included aspirin with clopidogrel, or cilostazole. follow-up angiography was performed at sixth month. Baseline demographic characteristics and the incidence of short term adverse events were similar between both SES and BMS groups. At follow-up angiography, SES group showed the significantly lower incidences in adverse events (8.2% vs. 39.3%, p<0.01). late loss (0.38 ± 0.54 mm vs 1.34 ± 0.96 mm, p<0.01) and restenosis (5.9% vs. 35.6%, p<0.01) comparing to BMS group. Therefore, SES implantation could be a safe and effective strategy for the treatment in patients with AMI.
2nd Southeastern Europe FLUENT Users Group Meeting

The influence of the blade passage in the vicinity of a HAWT tower is investigated numerically with FLUENT and experimentally in wind tunnel. Attention is focused in the velocity and unsteady pressure fields Around the blade. For simplicity the flip type 2–D case is considered, where the blade (2−D wing with NACA 63 215 profile) is stationary while the tower (a circular cylinder) is rotated. The conditionally averaged magnitudes of wake velocities and blade lifts are in good agreement with those calculated by FLUENT. It is also encouraging that the phase positions of the experimental velocity and lift overshoot correspond to the calculated ones.
Successful Allogeneic Hematopoietic Stem Cell Transplantation in XIAP Deficiency Using Reduced‐Intensity Conditioning

Hematopoietic stem cell transplantation (HSCT) is currently the only available curative therapy for X‐linked inhibitor of apoptosis (XIAP) deficiency. Myeloablative conditioning regimens are associated with high mortality rates. Reduced‐intensity conditioning (RIC) is recommended in order to decrease treatment‐related toxicities, but RIC regimens increase the risk for mixed donor‐recipient chimerism that may progress to graft loss. We report our experience with a patient with XIAP deficiency who was successfully treated with allogeneic HSCT using a RIC protocol. Post‐transplant chimerism was vigilantly monitored and maintained with donor lymphocyte infusions and a stem cell boost to a level that prevented hemophagocytic lymphohistiocytosis recurrence. Pediatr Blood Cancer © 2015 Wiley Periodicals, Inc.
Influence of 90 Years of Protection From Grazing on Plant and Soil Processes in the Subalpine of the Wasatch Plateau, USA

Abstract Human communities in the Intermountain West depend heavily on subalpine rangelands because of their importance in providing water for irrigation and forage for wildlife and livestock. In addition, many constituencies are looking to managed ecosystems to sequester carbon in plant biomass and soil C to reduce the impact of anthropogenic CO2 on climate. This work builds on a 90-year-old grazing experiment in mountain meadows on the Wasatch Plateau in central Utah. The purpose of this study was to evaluate the influence of 90 years of protection from grazing on processes controlling the input, output, and storage of C in subalpine rangelands. Long-term grazing significantly reduced maximum biomass in all years compared with plots within grazing exclosures. For grazed plots, interannual variability in aboveground biomass was correlated with July precipitation and temperature (R2 = 0.51), while there was a weak correlation between July precipitation and biomass in ungrazed plots (R2 = 0.24). Livestock grazing had no statistically significant impacts on total soil C or particulate organic matter (POM), although grazing did increase active soil C and decrease soil moisture. Grazing significantly increased the proportion of total soil C pools that were potentially mineralizable in the laboratory, with soils from grazed plots evolving 4.6% of total soil C in 1 year while ungrazed plots lost 3.3% of total soil C. Volumetric soil moisture was consistently higher in ungrazed plots than grazed plots. The changes in soil C chemistry may have implications for how these ecosystems will respond to forecast climate change. Because grazing has resulted in an accumulation of easily decomposable organic material, if temperatures warm and summer precipitation increases as is anticipated, these soils may become net sources of CO2 to the atmosphere creating a positive feedback between climate change and atmospheric CO2.
Does Emotional Intelligence Assist in the Prediction of Academic Success?

Some authors have claimed that emotional intelligence predicts success at work, at school, and in relationships, as well as or better than IQ. Little research exists to support or refute this claim at present. In this study, the ability of emotional intelligence to predict academic achievement was examined in a sample of undergraduate psychology students, using year-end grades as the criterion. The predictive validity of emotional intelligence was compared with the predictive validity of traditional cognitive abilities and the Big Five dimensions of personality. In addition, the incremental predictive validity of each of these three domains was assessed. In this setting, only some measures of Emotional Intelligence predicted academic success, and none of these measures showed incremental predictive validity for academic success over and above cognitive and personality variables. It may be that the overlap between many emotional intelligence measures and traditional measures of intelligence and personality limits their incremental predictive validity in this context.
Affective symptoms associated with the onset of major depression in the community: findings from the US National Institute of Mental Health Epidemiologic Catchment Area Program

This study examined the strength of relationships between forms of depressive symptoms over a one‐year period and the onset of major depression. The data analyzed were collected in 4 sites of the US National Institute of Mental Health Epidemiologic Catchment Area Program (NIMH‐ECA, 1981–1985). The Diagnostic Interview Schedule's specifications of DSM‐III criteria for major depression were employed. Overall, the results indicated a strong positive association between an onset episode and the following depressive symptoms over 1 year: diminished sexual drive, feelings of worthlessness or excessive guilt and trouble concentrating or thinking. Sleep disturbance among women and fatigue among males were also significantly associated with experiencing an onset of major depression. The implications of the findings for secondary prevention efforts are explored.
Functional specialization of duplicated AP3-like genes in Medicago truncatula.

The B-class of MADS box genes has been studied in a wide range of plant species, but has remained largely uncharacterized in legumes. Here we investigate the evolutionary fate of the duplicated AP3-like genes of a legume species. To obtain insight into the extent to which B-class MADS box gene functions are conserved or have diversified in legumes, we isolated and characterized the two members of the AP3 lineage in Medicago truncatula: MtNMH7 and MtTM6 (euAP3 and paleoAP3 genes, respectively). A non-overlapping and complementary expression pattern of both genes was observed in petals and stamens. MtTM6 was expressed predominantly in the outer cell layers of both floral organs, and MtNMH7 in the inner cell layers of petals and stamens. Functional analyses by reverse genetics approaches (RNAi and Tnt1 mutagenesis) showed that the contribution of MtNMH7 to petal identity is more important than that of MtTM6, whereas MtTM6 plays a more important role in stamen identity than its paralog MtNMH7. Our results suggest that the M. truncatula AP3-like genes have undergone a functional specialization process associated with complete partitioning of gene expression patterns of the ancestral gene lineage. We provide information regarding the similarities and differences in petal and stamen development among core eudicots.
Sociocultural Determinants of Breast and Cervical Cancer Screening Adherence: An Examination of Variation among Immigrant Latinas by Country of Origin

This paper seeks to examine differences in sociodemographic characteristics and culturally-relevant psychosocial and interpersonal factors across four sub-groups of immigrant Latinas, and how these factors are associated with adherence to age-specific breast and cervical cancer screening. Data come from a baseline survey using an electronic audience response system from a randomized controlled trial to test the effectiveness of a cancer screening program in New York and Arkansas (n=1,548). Mexican women were least likely to be adherent to cancer screening tests (clinical breast exam, mammogram, or Pap test). Mexican women also differed from the other sub-groups in terms of sociodemographics, barriers, and interactions within the health care system. Correlates of screening adherence differed by country of origin, with the exception of spouse/partner attendance at the program, which was negatively associated with adherence across several sub-groups. Findings provide important information about Latina sub-group variability that can help inform the development of breast and cervical cancer screening interventions.
Medición de las capacidades tecnológicas en la industria mexicana

Este trabajo realiza una aportacion metodologica y analitica a la linea de investigaciones abocadas a construir indices representativos de las capacidades tecnologicas de las empresas manufactureras mexicanas. Asimismo, examina la distribucion de estas capacidades en una muestra de estos establecimientos y su asociacion con variables de desempeno con base en una muestra de 1.818 empresas. Mediante el analisis factorial se identificaron cuatro factores que expresan las principales fuentes de aprendizaje en la empresa manufacturera: i); politica de formacion de personal, ii); innovacion de mejora continua, iii); sistemas de informacion y documentacion, y iv); inversion en nuevas tecnologias. El analisis de agrupamientos permitio identificar cuatro grupos de empresas en funcion de los puntos obtenidos por factor y examinar sus indicadores de desempeno. Se observo que hay una asociacion positiva entre capacidades tecnologicas y desempeno en tres de los cinco indices: el margen de ganancia, la productividad laboral y el cambio tecnico.
Las consonantes fricativas de la lengua gallega

El inventario de sonidos fricativos de la lengua gallega abarca un amplio rango de zonas articulatorias, desde los labios a la glotis. Si bien la variedad estandar recoge unicamente las fricativas anteriores [] [] y medias  []1, otras -como las sibilantes dental [ y laminal [s]- son propias de areas dialectales del oeste de Galicia. Por otra parte, y tambien en las provincias occidentales del pais gallego, se producen una serie de realizaciones fricativas posteriores, entre las cuales la faringea   -mayoritaria- alterna con la velar [x], uvular   e incluso glotal  . En este articulo analizaremos las propuestas descriptivas de los diferentes autores y las contrastaremos con los resultados de las investigaciones en torno a la acustica de estos sonidos. Podremos ver asi hasta que punto la descripcion articulatoria queda confirmada por los analisis acusticos.
Effect of inhibition of nitric oxide formation on coronary blood flow during exercise in the dog.

OBJECTIVE The aim was to test the hypothesis that nitric oxide (or a related compound) contributes to the coronary vasodilatation during physiological increases of myocardial O2 consumption that occur with exercise. METHODS Active hyperaemia associated with graded treadmill exercise and coronary reactive hyperaemia were examined in chronically instrumented awake dogs during control conditions and after administration of the nitric oxide synthase inhibitor, N-nitro-L-arginine (LNNA). RESULTS LNNA blunted the response to intracoronary acetylcholine, with an 80(SEM 6)% decrease in the maximum acetylcholine induced coronary vasodilatation, but did not alter the response to sodium nitroprusside. Increases of myocardial oxygen requirements during treadmill exercise were associated with progressive increases of coronary blood flow. LNNA caused a significant increase in arterial pressure at rest and during exercise, and this was associated with slightly but significantly higher myocardial oxygen consumption. Coronary blood flow-during exercise was also slightly higher after LNNA, while coronary vascular resistance was unchanged. Coronary sinus PO2 was slightly but significantly lower during exercise after LNNA, indicating that coronary vasodilatation in response to the increased myocardial oxygen demands during exercise was slightly blunted by LNNA. LNNA did not alter the peak increase in blood flow during reactive hyperaemia following a 15 s coronary occlusion, but decreased the duration of the response and decreased reactive hyperaemia debt repayment from 300(56)% during control conditions to 182(36)% after LNNA (p < 0.01). CONCLUSIONS LNNA antagonised coronary vasodilatation in response to acetylcholine and blunted coronary reactive hyperaemia, but did not substantially impair the coronary vasodilatation associated with increased myocardial oxygen requirements produced by exercise. These findings fail to support an essential role for nitric oxide in coronary resistance vessel dilatation during exercise in the dog.