Miracle-dz/UniFAR-FTUs huggingface dataset:
Haematopoietic toxicity of radium-223 in patients with high skeletal tumour burden

Summary In patients with metastasized, castration resistant prostate cancer (mCRPC) treatment with radium-223 (Xofigo) is an attractive therapeutic option. In particular, patients with high tumour load seem to profit from this treatment in regard of survival and quality of live. Aim of this study was to stratify mCRPC patients according to a quantitative imaging marker derived from routine bone scans (EXINI bone) and analyze haematopoietic toxicity of Xofigo in these patients. Patients, methods: Toxicity and oncologic outcome were investigated in a cohort of 14 patients with high tumour load. Additionally, based on a web survey, experience of toxicity in 41 high tumour load patients in Germany in 2014 was collected. Results: In patients with a bone scan index (BSI) greater than 5, significant toxicity occurred in more patients than expected from the ALSYMPCA trial. This was associated with application of fewer cycles. Similar experiences have been made in other centers in Germany. Approximately 7% of these patients will need very long time or will not recover from grade ≥ 3 toxicity. Conclusion: Close follow-up of haematopoietic indices and, in case of toxicity, early termination of therapy is in particular necessary in late stage disease where limited bone marrow reserve is likely.
Chronic migraine in the population

Objective: To evaluate the disability profile and patterns of treatment and health care use for chronic migraine (CM) in the general population, in contrast to episodic migraine. Methods: We identified 24,000 headache sufferers, drawn from more than 165,000 individuals representative of the US population. This sample has been followed up with annual surveys using validated questionnaires for the diagnosis of episodic migraine and CM. As a part of the survey, subjects were asked to report the specific medications currently used for their most severe headaches, as well as level of satisfaction with treatment. Results: Our sample consisted of 520 individuals with CM and 9,424 with episodic migraine. Over a 3-month period, more than half of the individuals with CM missed at least 5 days of household work, compared with 24.3% of those with episodic migraine (p < 0.001). Reduced productivity in household work for at least 5 days over 3 months was reported by 58.1% and 18.2% (p < 0.001); at least 5 days of missed family activities was reported by 36.9% and 9.5% (p < 0.001). The majority of the CM sufferers (87.6%) had previously sought care to discuss their headaches with a health professional. Migraine-specific acute treatments were used by 31.6% of respondents with CM and 24.8% with episodic migraine. Around 48% of the individuals with CM were satisfied with their acute therapies. Just 33.3% of those with CM were currently using preventive medications. Conclusion: Chronic migraine (CM) is more disabling than episodic migraine in the population. Although most individuals with CM sought medical care for this disorder, the majority did not receive specific acute or preventive medications.
Regulation of CD 4 + NKG 2 D + Th 1 cells in patients with metastatic melanoma treated with Sorafenib : role of IL-15 R α and NKG 2 D triggering

1 Cancer Institute Gustave Roussy, Villejuif, France 2 INSERM, U1015, Villejuif, France 3 Center of Clinical Investigations CBT507, Biotherapy, Villejuif, France 4 INSERM, U892, Institut de Recherche Thérapeutique, Nantes, France 5 INSERM, U1016, Saint Vincent de Paul Hospital, Paris, France 6 INSERM U1016, CNRS UMR8104, Cochin Institute, Paris, France 7 Department of Epidemiology and Statistics, Cancer Institute Gustave Roussy, Villejuif, France 8 Department of BioPathology, Translational Research Laboratory and Biobank, Institut Gustave Roussy, Villejuif,
β-Carotene Uptake and Bioconversion to Retinol Differ Between Human Melanocytes and Keratinocytes

β-Carotene is one of the carotenoids that has been considered to play a role in the natural defense against ultraviolet-induced skin cancer. It is not known whether epidermal cells are able to accumulate β-carotene and, subsequently, convert it to vitamin A. We used normal cultured human keratinocytes and melanocytes to study the uptake, and possible bioconversion to retinol, of authentic or [14C]β-carotene. The uptake was much higher in melanocytes than in keratinocytes, corresponding to a fivefold difference in the intracellular fraction after two days of incubation. An increased level of cellular retinol was noted after one day of β-carotene incubation. The conversion of [C]β-carotene to [14C]retinol peaked at 24 hours of incubation in keratinocytes and melanocytes. The results suggest that β-carotene can function as a local supply of vitamin A in the skin and that melanocytes are especially likely to store β-carotene.
Vanishing White Matter Disease Associated With Ptosis and Myoclonic Seizures

A 5-year-old boy who presented with progressive ataxia, neuroregression, and worsening with febrile illnesses is described. He also had myoclonic jerks and ptosis. His elder sister had died of a similar illness. Serial magnetic resonance imaging of the brain demonstrated extensive abnormality of the cerebral white matter with rarefaction and cystic degeneration, suggestive of vanishing white matter disease. The patient was found to be compound heterozygous for 2 new mutations in the gene EIF2B5, confirming the diagnosis.
Simultaneous detection of hepatitis C virus core antigen and antibodies in Saudi drug users using a novel assay

Drug users and particularly, injecting drug users, are at increased risk for infection with hepatitis C virus (HCV). The aims of the study were to simultaneously detect HCV core antigen and specific antibodies in sera from Saudi drug users using the new HCV combination assay and to compare this data with HCV core antigen, anti‐HCV antibodies and HCV RNA data from the same patients. A total of 297 patients who are followed up or admitted to a drug rehabilitation hospital over a period of 3 years were included in this study. Samples were analyzed using the new HCV Ag/Ab combination assay (Meurex), HCV core Ag assay, HCV antibodies and with the HCV RNA assay. Out of the 297 samples from Saudi drug users, 111 samples (37.4%) have detectable HCV core Ag, 112 samples (37.7%) have detectable HCV antibodies, 118 have detectable HCV RNA, and 116 samples were positive by the HCV Ag/Ab combination assay (39.1%). Out of the 116 samples, HCV core Ag was detected in 110 samples (94.8%), HCV antibodies were detected in 111 (95.7%) samples and HCV RNA was detected in 114 samples (98.3%). In the control group (n = 305), only 2 (0.66%) blood donor were positive by HCV antibodies assay, HCV RNA assay as well as HCV Ag/Ab combination assay. The new HCV Ag/Ab combination assay may well improve the overall quality of diagnosis of HCV infection especially in high risk population such as drug users that necessitates rigorous testing. J. Med. Virol. 80:603–606, 2008. © 2008 Wiley‐Liss, Inc.
Linear association between maternal age and spontaneous breech presentation in singleton pregnancies after 32 weeks gestation

Abstract Purpose: To investigate the association between maternal age and spontaneous breech presentation. Material and methods: Fifteen-year observational study over (2001–2015). All consecutive singleton births delivered at the Centre Hospitalier Universitaire Sud Reunion’s maternity. The only single exclusion criterion was uterine malformations (N = 123) women. Results: Of the 60,963 singleton births, there was a linear association (χ2 for linear trend, p< 0.0001) between maternal age and spontaneous breech presentation. Overall rate of breech presentation was 2.7% in deliveries over 32 weeks gestation, while it was 1.9% in women aged 15 to 19 years and 4.0% in women aged 45+, with a linear progression for each 5-year age category. This linearity remained significant controlling for early prematurity (<33 weeks) and severe fetal malformations (χ2 for linear trend = 64, p < 0.0001). Controlling in a multiple logistic regression model for other major risk factors gestational age, female sex, primiparity, maternal age remained significantly an independent risk factor, p < 0.0001. Conclusion: Maternal age (x) is an independent factor for breech presentation in singleton pregnancies after 32 weeks gestation with a linear association that may be approximated at y = 0.1x. (y: incidence, percent).
Defects in Transient tRNA Translocation Bypass tRNA Synthetase Quality Control Mechanisms*

Quality control mechanisms during protein synthesis are essential to fidelity and cell survival. Leucyl-tRNA synthetase (LeuRS) misactivates non-leucine amino acids including isoleucine, methionine, and norvaline. To prevent translational errors, mischarged tRNA products are translocated 30Å from the canonical aminoacylation core to a hydrolytic editing-active site within a completely separate domain. Because it is transient, the tRNA translocation mechanism has been difficult to isolate. We have identified a “translocation peptide” within Escherichia coli LeuRS. Mutations in the translocation peptide cause tRNA to selectively bypass the editing-active site, resulting in mischarging that is lethal to the cell. This bypass mechanism also rescues aminoacylation of an editing site mutation that hydrolyzes correctly charged Leu-tRNALeu. Thus, these LeuRS mutants charge tRNALeu but fail to translocate these products to the hydrolytic site, where they are cleared to guard against genetic code ambiguities.
Journal club as a method for nurses and nursing students' collaborative learning: a descriptive study

Background: Nurses and nursing students need competence to produce evidence based care. Journal clubs have been suggested as learning methods for promoting these competences. There is a lack of knowledge about journal clubs implemented for nurses’ and nursing students’ collaborative learning. Aim: The aim of the present study was to explore nurses’ and nursing students’ experiences of journal clubs implemented as learning methods for collaborative learning. Method and material: A six-phased journal club model was used in this study. The journal clubs (n=41) were implemented in 2010-2011. The population consisted of nurses at psychiatric, geriatric, surgical or internal disease wards and students attending geriatric, psychiatric, medical nursing, health psychology or home care study modules. The sample consisted of nurses (n=216) and students (n=235). The data was collected using a semi-structured questionnaire. Results: Nurses (90%) experienced the journal clubs to be advantageous, to meet their expectations and facilitate discussion regarding the implementation of research into clinical practice. Nurses (80%) gained new knowledge and would utilise the knowledge in their work. Students (75%) experienced their competences to search, evaluate and communicate scientific knowledge to improve and the collaboration with the nurses to be advantageous. Students, however, experienced journal clubs as demanding and several developmental needs were reported. Conclusion: Journal clubs support competences and discussion required for producing evidence based care and can be recommended as learning methods for nurses’ and nursing students’ collaborative learning. Further research is needed to assess the effects of journal clubs on learning as well as clinical nursing outcomes.
Soil organic phosphorus in tropical forests: an assessment of the NaOH–EDTA extraction procedure for quantitative analysis by solution 31P NMR spectroscopy

The extraction of soil organic phosphorus by the NaOH–EDTA procedure was assessed in detail for a tropical forest soil (clay‐loam, pH 4.3, total carbon 2.7%). Optimum conditions for the quantification of soil organic phosphorus and characterization of its composition by solution 31P NMR spectroscopy were extraction in a solution containing 0.25 m NaOH and 50 mm Na2EDTA in a 1:20 solid to solution ratio for 4 hours at ambient laboratory temperature. Replicate analyses yielded a coefficient of variation of 3% for organic phosphorus as a proportion of the spectral area. There was no significant difference in total phosphorus extraction from fresh and air‐dried soil, although slightly more organic phosphorus and less paramagnetic ions were extracted from dried soil. The procedure was not improved by changing the concentration of NaOH or EDTA, extraction time, or solid to solution ratio. Pre‐extraction with HCl or Na2EDTA did not increase subsequent organic phosphorus extraction in NaOH–EDTA or improve spectral resolution in solution 31P NMR spectroscopy. Post‐extraction treatment with Chelex resin did not improve spectral resolution, but removed small concentrations of phosphorus from the extracts. Increasing the pH of NaOH–EDTA extracts (up to 1.0 m NaOH) increased the concentration of phosphate monoesters, but decreased DNA to an undetectable level, indicating its hydrolysis in strong alkali. The standardized NaOH–EDTA extraction procedure is therefore recommended for the analysis of organic phosphorus in tropical forest soils.
Blood-brain barrier disturbance following localized hyperthermia in rats.

We investigated the morphological effect of hyperthermia on the blood-brain barrier (BBB). The heads of rats were heated locally using flood-lamps. BBB changes were assessed morphologically with horseradish peroxidase (HRP). Histological examinations were carried out 2 and 6 h, 1 and 3 days, and 1 week after the hyperthermia. The acute thermal lesions had three zones, i.e. a necrotic zone, a reactive zone and a permeable zone of viable brain tissue. HRP extravasation was seen in the necrotic zone and the permeable zone. Electron micrographic observation revealed HRP had entered the CNS through damaged endothelial cells and disruption of the tight junctions in the necrotic zone, and through numerous pinocytotic vesicles in the permeable zone. BBB opening to HRP was observed from 6 h to 3 days after hyperthermia.
Personality Disorder and Psychiatric Illness in General Practice

In a one-year prevalence study of conspicuous psychiatric morbidity in two group general practices, one urban and the other rural, personality disorder was diagnosed in 5.3% by the GP and in 5.6% by the psychiatrist, but this increased to 28% when personality disorder was assessed using a structured interview. The prevalence of personality disorder was higher in the urban practice than in the rural one but there was no consistent association between personality disorder and mental state disorder, with the exception of alcohol abuse and dependence. The high rate of personality disorder found using the interview schedule is likely to be a true finding, and failure to recognise this hidden morbidity is important in both general and psychiatric practice.
Cerebral edema following carotid artery ligation in the gerbil.

The mongolian gerbil has an anomalous circle of Willis, lacking a major posterior communicating artery. Fatal cerebral infarction followed unilateral carotid artery ligation in the neck in 60% of the cases studied. This mortality was reduced by large intraperitoneal injections of dexamethasone. Evidence is presented that this reduction in mortality is associated with a significant reduction in cerebral edema in the infarcted hemisphere.
Key words: Children: Active gaming: Energy intake: Physical activity: Appetite

Title: Acute effects of active gaming on ad-libitum energy intake and appetite sensations of 8-to-11 year-old boys. Abstract 28 The present study examined the acute effects of active gaming on energy intake (EI) and 29 appetite responses in 8-11 y boys in a school-based setting. Using a randomized crossover design, 30 21 boys completed four individual 90 min gaming bouts, each separated by 1 week. The gaming 31 bouts were 1) seated gaming no food or drink; 2) active gaming no food or drink; 3) seated gaming, 32 food and drink offered ad-libitum and 4) active gaming, food and drink offered ad-libitum. In the 33 two gaming bouts during which foods and drinks were offered, EI was measured. Appetite 34 sensations; hunger, prospective food consumption and fullness were recorded using visual analogue 35 scales (VAS) during all gaming bouts at 30 min intervals and at two 15 min intervals post-gaming. 36 In the two bouts with food and drink, no significant differences were found in acute EI (MJ) 37 ( p =0.238). Significant differences were detected in appetite sensations for hunger, prospective food 38 consumption and fullness between the four gaming bouts at various time-points. The relative energy 39 intake calculated for the two gaming bouts with food and drink (active gaming 1.42±0.28 MJ; 40 seated gaming 2.12±0.25 MJ) was not statistically different. Acute EI in response to active gaming 41 was no different to seated gaming and appetite sensations were influenced by whether food was 42 made available during the 90 min gaming bouts. 43 = moderate effect, and ≥0.80 = large effect (40) . Statistical significance was set at p < 0.05 for all analyses.
Day ahead hourly electricity price prediction in ISO new england market using neuro-fuzzy systems

Electricity price forecasting is a potential challenge for market participants and managers due to the high volatility of electricity prices. Price forecasting is also considered as an important management goal for market participants since it forms the basis of maximizing profits. These markets are usually organized in power pools and administrated by the independent system operator (ISO). The aim of this study is to examine the performance of asymmetric neuro-fuzzy network models for day-ahead electricity price forecasting in the ISO New England market. The implemented model has been developed with two alternative defuzzification models. The first model follows the Takagi-Sugeno-Kang scheme, while the second follows the traditional centre of average method. A clustering scheme is utilised as a pre-processing step to derive the necessary number of clusters and eventually the number of fuzzy rules in the network. Simulation results corresponding to the minimum and maximum electricity price indicate that the proposed network architectures could provide a considerable improvement for the forecasting accuracy compared to alternative learning-based schemes.
Reproductive Outcome in Women with Congenital Uterine Anomalies

Background: Mullerian duct malformations delineate a group of congenital anomalies that result from arres-ted development, or incomplete fusion of the mesone-phric ducts. In many patients, uterine anomalies have been related with infertility, recurrent pregnancy loss, prematurity and other obstetric complications which increase perinatal morbidity and mortality rates, where as in others these malformations are asymptomatic and have normal reproductive performance. Purpose: To determine the reproductive outcome in women with congenital uterine anomalies. Design: Descriptive cross sectional survey. Main Outcome Measures: Miscarriages, Preterm delivery, Ecotpic pregnancy, Term delivery. Material and Methods: A total of 1600 infertile women in the age group of 25 - 35 years were rec-ruited in the outpatient department of Gynae and Obs-tetrics in Sharif Medical City Hospital from June, 2008 to June, 2009. The patients included in study were the women presenting with either primary or secondary infertility, bad obstetrical history, recurrent miscar-riage, preterm deliveries, and ectopic pregnancies. Combined finding of trans-vaginal ultrasonography and hysterosalpingography were used to diagnose con-genital uterine anomalies. 48 women were diagnosed with congenital uterine anomalies. Eight patients of primary infertility with uterine anomalies were excluded. The retrospective analysis of 40 cases with secon-dary infertility and uterine anomalies was done for reproductive performance. Results: Among 1600 infertile women, the average age of the study group was 30 years ± SD 4.77. Forty eight patients were diagnosed with congenital uterine abnormalities. Among infertile population the most frequent uterine anomalies was bicornuate uterus (45.83%) followed by arcuate uterus (33.33%). The overall frequency of congenital uterine anomalies was 3%. Women with secondary infertility (83.3%) had higher frequency of mullerian duct anomalies in com-parison to women with primary infertility (16.7%). In all these abnormalities, miscarriages (25%) and pre-term delivery (22.5%) were quite common. ( P <.0750). The reproductive potential of the bicornuate uterus showed a live birth rate of (67%) and, arcuate uterus of (42.8%). Unicornuate and Septate uterus were associ-ated with poor obstetrical outcome. Conclusion: Congenital uterine anomalies are rela-tively frequent among infertile population and are associated with higher miscarriages and preterm births but may be compatible with normal reproductive out-come. Key Words: Uterine anomalies, preterm birth, mis-carriages.
Effects of overlearning on the retention of a gross motor skill.

Abstract Four groups of 20 subjects each practiced the skill of balancing on a stabilometer to a learning criterion and then received either 0, 50, 100 or 200 percent overlearning practice. One-half of the subjects in each of the four groups returned for retention testing after one week while the other half returned after one month. Absolute and relative retention scores were calculated for each subject and then statistically analyzed. The results showed that immediate recall of the skill following the two retention intervals was facilitated by overlearning, 50% overlearning proving, in most instances, as effective as 100 and 200 percent. Relative retention scores were not significantly better after one week and one month for those subjects receiving 50 and 100 percent overlearning; however, the subjects who received 200% overlearning had significantly better retention than the subjects who had 0% overlearning following the one-month retention interval. Further analysis of retention scores revealed that d.
Sleep Apnea

Background: Sleep apnea is a condition that interrupts breathing while sleeping, usually caused by an obstruction blocking the back of the throat so that the air cannot reach the lungs. The brief cessation in breath automatically forces individuals to wake up and restart breathing. This can happen many times during the night, making it hard for the body to get enough oxygen, and impacts the sleep quality. It is the most common type of sleep disorder breathing. Objectives: The present study was designed to investigate the effects of obstructive sleep apnea (OSA) on different mental, physical and nervous disorders which are manifested in such patients. This study would not only benefit in ascertaining the causes of OSA through assessment of higher mental functions of autonomic and peripheral nervous systems but also in the development of algorithm for estimation of degree of damage to the nervous system with severity of OSA. Methods: The cohort by the of snoring and daytime of BMI, and circumference, clinical data as of insomnia, coronary overnight polysomnography cognitive function of mini-mental state the depression questionnaire self report The autonomic function tests were performed. Variabilities in heart rate were determined. Brain natriuretic peptide (BNP) levels in the blood were measured. Results: The study group had of while the differences