Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of efficacy of community‐based vs. institutional‐based direct observed short‐course treatment for the control of tuberculosis in Kilombero district, Tanzania

Tuberculosis (TB) has reappeared as a serious public health problem. Non‐compliance to antituber‐culous drug treatment is cited as one of the major obstacles to the containment of the epidemic. Compliance may be optimized by Directly Observed Treatment (DOT) and short‐course treatment regimens. Since 1986, Tanzanian TB patients have received daily DOT at health facilities for the first 2 months of the treatment course. However, adherence and cure rates have been falling as the number of TB cases continues to increase and the burden on already stretched health facilities threatens to become unmanageable. We used an open cluster randomized controlled trial to compare community‐based DOT (CBDOT) using a short‐course drug regimen with institutional‐based DOT (IBDOT). A total of 522 (301 IBDOT and 221 CBDOT) patients with sputum‐positive TB were recruited. Overall, there was no significant difference in conversion and cure rates between the two strategies [M‐H pooled odds ratio (OR) 0.62; 95% confidence interval (CI) 0.23, 1.71 and OR = 1.58; 95% CI 0.32, 7.88, respectively] suggesting that CBDOT may be a viable alternative to IBDOT. CBDOT may be particularly useful in parts of the country where people live far from health facilities.
Realized volatility of CO2 futures

The EU Emission Trading System (EU ETS) was created to reduce the CO2 and other greenhouse gas emissions at the lowest economic cost. In reality market participants are faced with considerable uncertainty due to price changes and require price and volatility estimates and forecasts for appropriate risk management, asset allocation and volatility trading. Although the simplest approach to estimate volatility is to use the historical standard deviation, realized volatility is a more accurate measure for volatility, since it is based on intraday data. Besides the stylized facts commonly observed in financial time series, we observe long-memory properties in the realized volatility series, which motivates the use of Heterogeneous Autoregressive (HAR) class models. Therefore, we propose to model and forecast the realized volatility of the EU ETS futures with HAR class models. The HAR models outperform benchmark models such as the standard long-memory ARFIMA model in terms of model fit, in-sample and out-of-sample forecasting. The analysis is based on intraday data (May 2007-April 2012) for futures on CO2 certificates for the second EU-ETS trading period (expiry December 2008-2012). The estimation results of the models allow to explain the volatility drivers in the market and volatility structure, according to the Heterogeneous Market Hypothesis as well as the observed asymmetries. We see that both speculators with short investment horizons as well as traders taking long-term hedging positions are active in the market. In a simulation study we test the suitability of the HAR model for option pricing and conclude that the HAR model is capable of mimicking the long-term volatility structure in the futures market and can be used for short-term and long-term option pricing.
Differential Expression Analysis on RNA-Seq Count Data Based on Penalized Matrix Decomposition

With the development of deep sequencing, vast amounts of RNA-Seq data have been generated. It is crucial how to extract and interpret the meaningful information contained in deep sequencing data. In this paper, based on penalized matrix decomposition (PMD), a novel method, named PMDSeq, was proposed to analyze RNA-seq count data. Firstly, to obtain the differential expression matrix, the matrix of RNA-seq count data was normalized. Secondly, the differential expression matrix was decomposed into three factor matrices. By imposing appropriate constraint on factor matrices, the PMDSeq method can highlight the differentially expressed genes. Thirdly, the proposed method can identify the differentially expressed genes based on the scaled eigensamples. Finally, we used gene ontology tools to check these differentially expressed genes. The experimental results on simulation and three real RNA-seq count data sets demonstrated the effectiveness of our method.
The role of the antioxidant vitamin supplementation in the prevention of cardiovascular diseases

Industrial and technological revolutions have resulted in dramatic shifts in the diseases that are responsible for illness and death. In particular, cardiovascular disease (CVD) has emerged as the dominant chronic disease in many parts of the world. Diet, tobacco smoking, physical inactivity, obesity, lipid levels, hypertension and diabetes mellitus have contributed to their wide diffusion. Oxidative damage and the production of free radicals in the endothelium are two of the main factors involved in the pathogenesis of the atherosclerotic process that causes CVD. One of the more important results of basic research on dietetic regimes has shown that people who consume large amounts of fruits and vegetables have a lower incidence of CVD, stroke and tumours, but the specific mechanisms of these foods (which have an apparently protective effect) are still not completely clear. Possible reasons could include a greater consumption of fruit and vegetables, and an increased consumption of dietetic fibres. Recently, it been proposed that micronourishments with an antioxidant activity could be responsible for the reduction of chronic diseases. Research supplies a hypothetical mechanism by which antioxidant substances may be reducing the risk of atherosclerosis through the inhibition of oxidative damage. Appropriate nutritional practices are of central importance in managing risk and treatment of CVD; in fact, many current guidelines for a healthy general population contain nutritional recommendations to reduce the risk of these diseases. A large number of descriptive and case-control studies suggests that the consumption of many antioxidant vitamins (A, C and E) reduces the risk of CVD. Such data raises the following problem of whether supplementation of vitamins A, C and E emerges as being useful in the primary prevention of CVD. Many important studies involving a great number of participants have not confirmed this hypothesis and the results are often contradictory. This review examines the studies published in the literature that document the effect of supplementation with antioxidant vitamins (A, C and E) in the primary and secondary prevention of CVD due to an atherosclerosis process.
Estimating the tourism induced environmental Kuznets curve in France

Abstract France has retained its position as the world’s favourite tourism destination. Accounting for around 83 million visitors and 4.2% of the total employment, the tourism sector in France contributes to nearly 9% of the total GDP. However, as reported by the World Tourism Organization, road and air travel related to tourism activities account for approximately 10% of the total CO2 emissions in the atmosphere, thereby contributing to severe air pollution. Thus, initiatives are necessary to prevent environmental damage that could have a corresponding detrimental effect on the tourism industry itself and slow down the country’s economic growth. This study utilises a vector error correction model (VECM) to investigate the relationship between polluting emissions, GDP levels, and tourism flows in France to test the validity of the environmental Kuznets curve (EKC) hypothesis for the period 1995–2014. Additionally, based on a joint analysis of long-run parameters and causality links, appropriate policy strategies are proposed to promote robust and sustainable long-run economic growth.
Effects of candesartan, an angiotensin II type 1 receptor blocker, on diabetic nephropathy in KK/Ta mice.

BACKGROUND Although therapeutic effects of angiotensin II type 1 receptor blocker (ARB) on renal injury in non-insulin dependant diabetes mellitus (NIDDM) have been demonstrated, the beneficial effects and their mechanisms in diabetic nephropathy have not been well evaluated. METHODS KK/Ta mice were divided into three groups according to the treatment: candesartan 4 mg/kg/day from 6 to 28 weeks of age (group I; early treatment); from 12 to 28 weeks of age (group II; late treatment); only vehicle (group III). BALB/c mice treated with vehicle were used as controls (group IV). Body weight (BW), systolic blood pressure (SBP), blood glucose, urinary type IV collagen and albumin excretion were measured every 4 weeks. Morphometry and immunohistology of albumin, transforming growth factor-beta1 (TGF-beta1) and Smad7 were performed in all groups. RESULTS BW and blood glucose were higher in groups I, II and III than in group IV from 8 weeks. SBP was markedly reduced in groups I and II compared with group III (p < 0.05, p < 0.005). Urinary type IV collagen and albumin excretion were increased in group III compared to group IV (p < 0.05, p < 0.005), whereas they were reduced in groups I and II when compared to group III (p < 0.05). Morphometric analysis revealed that the whole glomerular area (WGA), glomerular tuft area (GTA), extracellular matrix area (ECMA) and intraglomerular cell nuclei number (NIGCN) were significantly reduced in groups I, II and IV compared to group III at 28 weeks. In immunohistochemistry, TGF-beta1 expression in both glomeruli and tubules of groups I and II decreased compared to that of group III at 28 weeks, while Smad7 in group III glomeruli was reduced compared to that in groups I and II. CONCLUSIONS It appears that candesartan reduced urinary type IV collagen and albumin excretion, and attenuated glomerular hypertrophy and mesangial matrix accumulation by the TGF-betaS/Smad signaling pathway in KK/Ta mice with diabetic nephropathy.
A survey of British rheumatologists' DMARD preferences for rheumatoid arthritis.

OBJECTIVE To determine the current disease-modifying anti-rheumatic drug (DMARD) preferences of UK consultant rheumatologists. METHODS A questionnaire was sent in May 2002. We asked which DMARD(s) was most frequently preferred first and sought the most typical sequence of DMARDs, including DMARD combinations. Also we determined the extent to which prognostic and other factors influenced treatment choices. Comments were invited, written responses abstracted and key themes identified. RESULTS After two mailings, 331 (of 460; 72%) suitable questionnaires were returned. Ninety-five per cent (315/331) preferred methotrexate (154, 46.5%) or sulphasalazine (144, 43.5%) or either of these two (17, 5%) as first-choice agent. Of those who chose methotrexate first, 80% (123/154) ranked sulphasalazine second, 45% (55/123) combined sulphasalazine and methotrexate and 49% (27/55) then added hydroxychloroquine to this combination, in active disease. Of those who chose sulphasalazine first, 95% (137/144) ranked methotrexate second, 75% (113/150) preferring methotrexate monotherapy and 12% (18/150) the combination with sulphasalazine. Rheumatologists who preferred sulphasalazine first more commonly used subsequent DMARDs singly than those who started with methotrexate (P < 0.0001). Leflunomide was more commonly preferred than intramuscular gold as third choice (52/145 vs 29/145; P < 0.003). The most popular sequence of DMARDs was methotrexate or sulphasalazine, singly or in combination, leflunomide, intramuscular gold and anti-tumour necrosis factor therapy. Poor prognostic factors influenced DMARD choice, but patient occupation and drug costs did not. CONCLUSION Methotrexate has displaced other DMARDs, especially sulphasalazine, as agent of first choice and newer agents have displaced older DMARDs. Whether the expressed preference for particular DMARDs accurately reflects actual use, and is optimal in rheumatoid arthritis, remains to be determined.
Regulation and expression of bba66 encoding an immunogenic infection‐associated lipoprotein in Borrelia burgdorferi

When Borrelia burgdorferi (Bb) is transmitted from a tick vector to a mammalian host the spirochaete alters gene expression, allowing for adaptation to the new host. We evaluated the regulation of paralogous gene family (pgf) 54 members in response to environmental cues and focused our efforts on determining the molecular mechanisms influencing bba66 expression. By qRT‐PCR, bba65, bba66, bba71 and bba73 displayed regulation similar to ospC under mammalian‐like conditions. Of the pgf 54 members, bba66 demonstrated the greatest and second greatest change in expression in response to pH or temperature shift respectively. Furthermore, Bb‐infected mice and patients with early disseminated Lyme disease produced detectable antibodies to BBA66. A protein(s) active in Bb at pH 7 was able to interact with the bba66 upstream region and was specific as bba64 and ospC promoters were unable to out‐compete for binding. bba66 promoter mapping revealed putative σ70 and σS consensus sequences, enabling us to narrow the protein binding site to a region within an imperfect inverted repeat upstream of the −35 region. Moreover, BBA66 production is associated with an infectious phenotype, and loss of either σN or σS resulted in loss of BBA66. Promoter‐GFP fusion analysis indicated that the σ70 and/or σS consensus sequences alone were not sufficient to initiate transcription and a portion of the upstream inverted repeat was required. These results suggest a primary role for BBA66 in Bb transmission and infection.
The relationship of disease duration to foot function, pain and disability in rheumatoid arthritis patients with foot complaints.

OBJECTIVE To assess the relationship between disease duration and foot function (expressed as pressure and gait parameters), foot pain and disability, in patients with foot complaints secondary to rheumatoid arthritis (RA). METHODS Sixty-two patients with RA-related foot complaints were included. Disease duration was defined as the time since RA was diagnosed. A pressure platform was used to measure both pressure parameters (i.e. pressure-time integrals and peak pressures in the forefoot) and gait parameters (i.e. total loading time and loading time in different foot regions). In addition, measurements of foot pain, disability (i.e. walking time and self reported disability), forefoot joint damage and disease activity were obtained. Data were analysed using partial correlations (Spearman), correcting for age. RESULTS Disease duration was significantly correlated with the maximum pressure-time integral (PTI) measured under the forefoot (r = 0.330, p = 0.01). Disease duration was also significantly correlated with gait parameters, i.e. total loading time (r = 0.265, p = 0.04), duration of heel loading and duration of toe loading (r = 0.326, p = 0.01 and r = -0.288, p = 0.03 respectively), and walking time (r = 0.297, p = 0.02). Disease duration did not correlate with self-reported foot pain or disability. CONCLUSION In patients with RA-related foot complaints, longer disease duration is associated with impaired foot function and reduced walking speed. These findings are interpreted as an alteration in pressure distribution and gait pattern during the course of disease, with a shift from a heel-to-toe roll-over process to a more shuffling gait.
MicroRNA-139-5p Inhibits Cell Proliferation and Invasion by Targeting RHO-Associated Coiled-Coil-Containing Protein Kinase 2 in Ovarian Cancer

Increasing evidence indicates that the dysregulation of microRNAs is associated with the development and progression of various cancers. MicroRNA-139-5p (miR-139-5p) has been reported to have a tumor suppressive role in many types of cancers. The role of miR-139-5p in ovarian cancer (OC) is poorly understood. The purpose of the present study was to explore the expression of miR-139-5p and its function in OC. The results showed that miR-139-5p expression was markedly downregulated in OC tissues and cell lines. In addition, underexpression of miR-139-5p was significantly associated with FIGO stage, lymph mode metastasis, and poor overall survival of OC patients. Functional analyses indicated that overexpression of miR-139-5p significantly inhibited proliferation, colony formation, migration, and invasion of OC cells. Rho-associated coiled-coil-containing protein kinase 2 (ROCK2) was identified as a direct target of miR-139-5p using luciferase reporter assays, qualitative real-time reverse transcriptase PCR (qRT-PCR), and Western blot. In addition, ROCK2 expression was upregulated and was inversely correlated with miR-139-5p levels in OC tissues. Rescue experiments showed that overexpression of ROCK2 effectively reversed the inhibitory effect of OC cells induced by miR-139-5p. Most interestingly, in vivo studies indicated that miR-139-5p markedly suppressed the growth of tumors by repressing ROCK2 expression in nude mice. Taken together, these findings demonstrated that miR-139-5p plays an important tumor suppressor role in OC by directly binding to ROCK2, providing a novel target for the molecular treatment of OC.
Occupational Exposure to Formaldehyde and Genetic Damage in the Peripheral Blood Lymphocytes of Plywood Workers

Occupational Exposure to Formaldehyde and Genetic Damage in the Peripheral Blood Lymphocytes of Plywood Workers: Dafeng LIN, et al. Institute of Occupational Medicine and the Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, China—
Colonial Deindustrialisation of India

While it is quite well accepted that the British rule imposed a heavy cost on India in terms of financial and industrial losses, the economic impact of the Company rule is still far from settled. Rule of the British East India Company (BEIC), and later the crown, has the scholars divided on whether the colonial India suffered a systematic draw down of its economic resources—the so-called drain theory. While the British version underplays or denies such a drain, the nationalists suggest it was a major long-term damage. This article reviews and critiques the economic policies of the British Raj in detail to know whether there was at all a drain of resources out of India and, if yes, to what extent. It was found that while the nationalists exaggerated effects of the drain, their arguments hold significant value. Finally, drain theory is assessed in the backdrop of the theory of unequal exchange.
The Effect of Accommodation on Ocular Shape

Purpose. Ocular shape is altered in myopia, and accommodation during nearwork is a proposed risk factor for myopia. Using relative peripheral refractive error (RPRE), ocular shape was assessed before, during, and after a period of sustained nearwork to determine whether accommodation affects ocular shape. Methods. Measurements of RPRE at 30° in the nasal visual field were obtained using the spherical equivalent calculated from Canon R-1 autorefraction. The RPRE of 41 young adults was measured on two separate occasions separated by at least 1 week to assess RPRE repeatability. Later, the RPRE of 22 young adults was measured at a 0 D accommodative stimulus and then at a 3 D stimulus level at 0, 1, and 2 h during which subjects performed sustained nearwork at 33 cm. After 2 h of nearwork, subjects had RPRE measured at prescribed time intervals over a 1-h period in which they looked in the distance (0 D stimulus). Results. The measurement of RPRE had adequate repeatability (mean difference ± SD, −0.05 ± 0.35 D) with ±0.68 D as the 95% limits of agreement. The onset of accommodation produced an immediate hyperopic shift of RPRE relative to baseline (+0.37 ± 0.44 D; p = 0.0007), indicating that ocular shape had become more prolate. This shape remained unchanged after 1 h of sustained accommodation (RPRE difference from baseline, +0.25 ± 0.55 D; p = 0.04) and then returned to baseline dimensions after 2 h of accommodation (RPRE difference from baseline, +0.11 ± 0.39 D; p = 0.21). At the 0 D stimulus level one minute after the period of nearwork, RPRE became more myopic relative to baseline (RPRE difference from baseline, −0.28 ± 0.50 D; p = 0.016). Ocular shape returned to baseline dimensions after 45 min of accommodative relaxation. Conclusions. Accommodation induced the ocular shape to become more prolate. The opposite occurred after accommodation was relaxed, namely a change toward a more oblate ocular shape. The transient nature of these changes suggests that tension on the choroid and choroidal hysteresis may play a role in influencing ocular shape.
Potential of entomopathogenic nematodes for the control of the banded fruit weevil, Phlyctinus callosus (Schönherr) (Coleoptera: Curculionidae)

Abstract Entomopathogenic nematodes (EPN) were evaluated for their potential use as biological control agents against Phlyctinus callosus, the banded fruit weevil (BFW). The susceptibility of larvae and adults to EPN was evaluated using 400 infective juveniles (IJ) per insect after 4 days in 24-well bioassay trays. The nematode isolates used were all able to infect BFW, although the larvae were found to be more susceptible than were the adults. The percentage mortality for BFW larvae ranged from 41 to 73% and for BFW adults from 13 to 45%. The most effective isolate, SF41 of Heterorhabditis zealandica, was used to investigate the effect of vertical movement of nematodes in sand and sandy loam soil, at specified concentration and temperature. A higher (82.2 ± 0.084%) percentage mortality rate was obtained with the sandy loam soil, than with the use of sand (67.5 ± 0.12%). The LD50 and LD90 values after 4 days of incubation were 96 and 278 IJ/50 μl, respectively. Nematodes were inactive below 15°C, with the highest mortality of 74 ± 0.081% for BFW larvae recorded at 25°C. Heterorhabditis zealandica was able to complete its life cycle successfully in sixth-instar BFW larvae after a period of 22 days. The study showed BFW larvae not to be as susceptible to nematode infection as they need a high concentration (400 IJ/larva) and 4 days to give effective control.
Investment in Research and Development Compared to Military Expenditure: Is Research Worthwhile?

Abstract Both research and development (R&D) and military expenditure are pivotal areas for any country’s economy. However, most countries tend to spend more on military because of global insecurity and power politics. Nevertheless, this study shows the merit of R&D investment and how it contributes to the national human capital. An analysis was undertaken on the gap between R&D and military expenditure considering the Human Development Index (HDI) and Gross Domestic Product (GDP) of 76 countries for a period of 15 years (2000–2014). Mixed effect models were applied to adjust the effect of six different continents. The results showed that HDI has a positive bi-directional significant relationship with higher R&D investment. National spending on R&D builds human capital, which in turn contributes to public development over the years, unlike military expenditure that only marginally contributes towards GDP and makes no contribution to HDI.
American Sign Language recognition by using 3D geometric invariant feature and ANN classification

Communication between normal and disabled person has been developed in several researches. The hand gesture is one of important communication for the deaf, especially American Sign Language (ASL) which is used in order to represent each alphabet (A-Z). This paper aims to translate ASL from static postures. Besides, this research also designs the glove with six different colored markers and develops algorithm for alphabet classification. Moreover the system is set by two cameras in order to extract 3D coordinate points from each marker. There are three main important processes for algorithm consisting of marker detection by using Circle Hough Transform, computation of all feasible triangle area patches constructed from 3D coordinate triplet that is novel feature, and feature classification using feedforward backpropagation of Artificial Neural Network. The experimental result shows average of accuracy is 95 percent that is high performance and feasibility for proposed method.