Miracle-dz/UniFAR-FTUs huggingface dataset:
Organizational Design For Business Units

This paper studies empirical differences across decentralized firms with respect to the allocation of tasks from the parent firm to its business units and the level of compensation risk imposed on business unit managers. We structure our empirical analysis around two hypothesized determinants of these organizational structure decisions: the parent firm's task expertise relative to that of the business unit's and the relative importance of the business unit to the performance of the parent firm. We develop a principal-agent model of the task allocation and compensation risk decisions as a function of these two determinants, and test several research hypotheses suggested by this model. In our analysis, we use the term relative expertise to refer to the competence of the parent, relative to the business unit manager, to make the division's operating decisions. Relative task expertise can be characterized in several ways; we consider three such characterizations and, using our model, find that they have different implications for the allocation of tasks and the imposition of compensation risk in decentralized firms.1 We label our three characterizations of relative expertise as follows: Cost
Treatment of Wilson disease with ammonium tetrathiomolybdate: IV. Comparison of tetrathiomolybdate and trientine in a double-blind study of treatment of the neurologic presentation of Wilson disease.

OBJECTIVE To compare tetrathiomolybdate and trientine in treating patients with the neurologic presentation of Wilson disease for the frequency of neurologic worsening, adverse effects, and degree of neurologic recovery. DESIGN A randomized, double-blind, controlled, 2-arm study of 48 patients with the neurologic presentation of Wilson disease. Patients either received 500 mg of trientine hydrochloride 2 times per day or 20 mg of tetrathiomolybdate 3 times per day with meals and 20 mg 3 times per day between meals for 8 weeks. All patients received 50 mg of zinc 2 times per day. Patients were hospitalized for 8 weeks, with neurologic and speech function assessed weekly; discharged taking 50 mg of zinc 3 times per day, and returned annually for follow-up. SETTING A university hospital referral setting. PATIENTS Primarily newly diagnosed patients with Wilson disease presenting with neurologic symptoms who had not been treated longer than 4 weeks with an anticopper drug. INTERVENTION Treatment with either trientine plus zinc or tetrathiomolybdate plus zinc. MAIN OUTCOME MEASURES Neurologic function was assessed by semiquantitative neurologic and speech examinations. Drug adverse events were evaluated by blood cell counts and biochemical measures. RESULTS Six of 23 patients in the trientine arm and 1 of 25 patients in the tetrathiomolybdate arm underwent neurologic deterioration (P<.05). Three patients receiving tetrathiomolybdate had adverse effects of anemia and/or leukopenia, and 4 had further transaminase elevations. One patient receiving trientine had an adverse effect of anemia. Four patients receiving trientine died during follow-up, 3 having shown initial neurologic deterioration. Neurologic and speech recovery during a 3-year follow-up period were quite good. CONCLUSION Tetrathiomolybdate is a better choice than trientine for preserving neurologic function in patients who present with neurologic disease.
Controversy and Conflict in the Treatment of Acute Decompensated Heart Failure: Nesiritide as Evidence‐Based Treatment

Acute decompensated heart failure poses a complex clinical challenge for the health care community. Evolving concepts of the pathophysiology and lack of consensus on appropriate outcome measures for drug approval underlie some of the current controversies about nesiritide. We outline the major controversies from the viewpoint that nesiritide should continue to be used judiciously by following its package insert recommendations and the Heart Failure Society of America's 2006 Comprehensive Heart Failure Practice Guidelines.
Multi‐scale network regression for brain‐phenotype associations

Complex brain networks are increasingly characterized at different scales, including global summary statistics, community connectivity, and individual edges. While research relating brain networks to demographic and behavioral measurements has yielded many insights into brain-phenotype relationships, common analytical approaches only consider network information at a single scale, thus failing to incorporate rich information present at other scales. Here, we designed, implemented, and deployed Multi-Scale Network Regression (MSNR), a penalized multivariate approach for modeling brain networks that explicitly respects both edge- and community-level information by assuming a low rank and sparse structure, both encouraging less complex and more interpretable modeling. Capitalizing on a large neuroimaging cohort (n = 1, 051), we demonstrate that MSNR recapitulates interpretable and statistically significant association between functional connectivity patterns with brain development, sex differences, and motion-related artifacts. Notably, compared to single-scale methods, MSNR achieves a balance between prediction performance and model complexity, with improved interpretability. Together, by jointly exploiting both edge- and community-level information, MSNR has the potential to yield novel insights into brain-behavior relationships.
Effect of physical activity and muscle morphology on endothelial function and arterial stiffness

Physically active persons have a reduced risk of atherosclerotic disease. Arterial stiffness and endothelial dysfunction are important risk factors for cardiovascular disease. A high proportion of type I (slow‐twitch) muscle fibers in skeletal muscle is associated with a favorable cardiovascular risk profile. We tested physical activity and muscle fiber‐type distribution as determinants of endothelial function and arterial stiffness in middle‐aged men. Fifty‐four men (median age 58) who underwent a muscle biopsy in 1984 were re‐studied in 2003. Aortic pulse wave velocity (PWV) and pulse wave reflection were assessed by applanation tonometry. Endothelial function was tested by examining the effects of salbutamol and nitroglycerin on pulse wave reflection. In multiple regression analyses aortic PWV (R2=0.51) correlated positively with age (P=0.017), BMI (P=0.001), and systolic blood pressure (P=0.004). A high augmentation index (R2=0.33) was associated with smoking (P<0.001), high LDL cholesterol (P=0.02), and elevated diastolic blood pressure (P=0.03). Impaired endothelial function (R2=0.37) was associated with high age (P=0.04), high LDL cholesterol (P=0.017), high triglycerides (P=0.027), and high physical activity (P=0.005). Muscle fiber‐type distribution is not a determinant of arterial stiffness or endothelial function. Impaired endothelial function was observed in physically active men, underlining the need for further research.
Failure to detect bovine immunodeficiency virus contamination of stud bull spermatozoa, blood leukocytes, or semen leukocytes in samples supplied by artificial insemination centers.

OBJECTIVE To determine whether bovine immunodeficiency virus (BIV) infection could be detected in spermatozoa, blood leukocytes, or semen leukocytes from stud bulls in artificial insemination centers. ANIMALS 30 bulls at 3 artificial insemination centers. PROCEDURE Polymerase chain reaction testing that used 3 sets of primer pairs targeting pol and env regions of the BIV proviral genome was performed on DNA extracted from semen leukocytes, spermatozoa, and blood leukocytes from each bull. Southern blot analysis was performed to increase sensitivity of detection. Western blot analysis of plasma samples was used to detect antibodies against BIV. RESULTS BIV provirus was not detected in DNA samples obtained from semen leukocytes, spermatozoa, or blood leukocytes, and antibodies against BIV were not detected. CONCLUSIONS AND CLINICAL RELEVANCE Contrary to our report of high point prevalence of BIV contamination of semen from a single artificial insemination center, bulls of the study reported here did not appear to be infected. Maximum risk of BIV infection in similar bulls was estimated at 10% with a confidence level of 95%.
Agency costs, executive incentives and corporate financial decisions

This paper investigates the roles of executive incentive structures in creating and mitigating investment-related agency costs. A model is developed which shows that underinvestment and overpayment of dividends are always expected to prevail when managers are offered short-term incentives, while overinvestment and underpayment of dividends are likely to exist when managers are offered long-term incentives. Using a large sample of non-financial US-listed firms over the period 1992–2009, it is found that managers underinvest and overpay dividends when offered vested stocks, but overinvest and underpay dividends when offered option incentives. An increase in these incentives, however, mitigates these problems. The results also suggest that, if properly constructed, long-term incentives might be superior to short-term incentives, and should be used alone in designing the optimal incentive package under certain conditions.
Pioneers of Financial Economics: Das Adam Smith Irrelevanzproblem?

This paper is a contribution to the debate surrounding the steady decline in importance of the history of economic thought within the economics curriculum. The relevance of the history of financial economics to this debate is examined and a ‘histories of economic thought’ strategy is suggested to improve the future prospects of the subject. In the process, Das Adam Smith Irrelevanzproblem is identified and discussed. Das Irrelevanzproblem is concerned with the question: why do Adam Smith and other classical political economists continue to play such a central role in traditional thought when the relevance of these thinkers to modern economics, particularly new additions such as financial economics, is so limited? This paper demonstrates that the history of financial economics commences at least a century prior to The Wealth of Nations and is largely independent of the traditional thought which commences with the role of Adam Smith as the leading Enlightenment thinker on issues relevant to political economy.
DISTRIBUTION OF INCOMES OF CORPORATIONS AMONG DIVIDENDS, RETAINED EARNINGS AND TAXES

Distribution of Incomes of Corporations Among Dividens, Retained Earnings, and Taxes Author(s): John Lintner Source: The American Economic Review, Vol. 46, No. 2, Papers and Proceedings of the Sixtyeighth Annual Meeting of the American Economic Association, (May, 1956), pp. 97-113 Published by: American Economic Association Stable URL: http://www.jstor. org/stable/1910664 Accessed: 26/06/2008 14:06
Metabolic Cost of Rope Training

Abstract Fountaine, CJ and Schmidt, BJ. Metabolic cost of rope training. J Strength Cond Res 29(4): 889–893, 2015—Rope training, consisting of vigorously undulating a rope with the upper body, has become a popular cardiovascular training choice in fitness centers and athletic performance enhancement facilities. Despite widespread use and growing popularity, little is known about the metabolic demands of rope training. Therefore, the purpose of this study was to quantify the cardiovascular and metabolic cost from an acute 10-minute bout of rope training. Eleven physically active participants used a 15.2-m rope anchored by a post, resulting in the participant holding 7.6 m of rope in each hand. The 10-minute protocol consisted of 15 seconds of vertical double-arm waves followed by 45 seconds of rest for 10 total repetitions. The metabolic cost was estimated from heart rate, lactate, resting O2 uptake, exercise O2 uptake, and excess postexercise O2 consumption measurements. The average heart rate for the workout was 163 ± 11 b·min−1 with peak of 35.4 ± 5.4 mL·kg−1·min−1, and peak METs were 10.1 ± 1.6. Total energy expenditure was 467.3 ± 161.0 kJ. When expressed per unit of time, EE was 41.3 ± 14.1 kJ·min−1. The results of this study suggest an acute 10-minute bout of rope training in a vigorous-intensity workout, resulting in high heart rates and energy expenditure, which meet previously established thresholds known to increase cardiorespiratory fitness.
Master Plan UMKM Berbasis Perikanan untuk Meningkatkan Pengolahan Produk Ikan yang Memiliki Nilai Tambah Tinggi

This research aims to generate a Master plan of fisheries-based SME development concept in Bali region, in order to build Bali as the centre for production and processing of fishery products in the Coridor of Bali-Nusa Tenggara. In Year-1 of the study period, the research activities carried out includes three processes, including analysis of the potensial of SMEs, analyzes the business cycle, and identification of barriers and chalenges. By using the method of linear regression analysis, Geographic Information System (GIS) and Analytical Hierarchy Process (AHP), the study result in Year-1, obtained some information about characteristics of fisheries based SMEs Bali, consisting of: 1) there is positive effect between GDP growth and energy work on the level of productivity (output value) of SMEs; 2) the need for development of fisheries-based SMEs in Bali include some operational, capital, and market access aspects. To the Bali Provincial Government, SMEs and the poblic are expected to synergize themselves, in term of institutionally, improving the quality of human recources, empowering financial institutions at the local level, as well as active participation in marketing access to the international level.
Free‐floating cryostat sections for immunoelectron microscopy: Bridging the gap from light to electron microscopy

Frozen skin sections are routinely used for light microscopic immunohistochemical study of the skin basement membrane zone for two reasons: some skin basement membrane zone proteins are labile to routine chemical fixation, and skin is not amenable to vibratome sectioning. However, inherent limitations of conventional frozen sections, including compromised morphology and a requirement for glass slide‐mounting, usually limit immunohistochemical study to the light microscopy level. In the present study, we introduce use of unfixed, free‐floating cryostat sections for characterization of immunolocalizations of selected skin basement membrane proteins at both the light and electron microscopy level. The new procedure employs free‐floating cryostat sections that can be processed as routine tissue specimens and can be subjected to a variety of special staining procedures including immunohistochemistry. Especially useful is the ease of progressive processing of the same tissue specimen from light microscopy to electron microscopy. In this regard, the method renders itself useful when results of immunolabeling experiments need to be elucidated quickly at histological and ultrastructural levels as required for diagnostic and accelerated investigative strategies. Microsc. Res. Tech. 54:246–253, 2001. © 2001 Wiley‐Liss, Inc.
Mapping Deforestation in North Korea Using Phenology-Based Multi-Index and Random Forest

Phenology-based multi-index with the random forest (RF) algorithm can be used to overcome the shortcomings of traditional deforestation mapping that involves pixel-based classification, such as ISODATA or decision trees, and single images. The purpose of this study was to investigate methods to identify specific types of deforestation in North Korea, and to increase the accuracy of classification, using phenological characteristics extracted with multi-index and random forest algorithms. The mapping of deforestation area based on RF was carried out by merging phenology-based multi-indices (i.e., normalized difference vegetation index (NDVI), normalized difference water index (NDWI), and normalized difference soil index (NDSI)) derived from MODIS (Moderate Resolution Imaging Spectroradiometer) products and topographical variables. Our results showed overall classification accuracy of 89.38%, with corresponding kappa coefficients of 0.87. In particular, for forest and farm land categories with similar phenological characteristic (e.g., paddy, plateau vegetation, unstocked forest, hillside field), this approach improved the classification accuracy in comparison with pixel-based methods and other classes. The deforestation types were identified by incorporating point data from high-resolution imagery, outcomes of image classification, and slope data. Our study demonstrated that the proposed methodology could be used for deciding on the restoration priority and monitoring the expansion of deforestation areas.
Carbonic anhydrase inhibitors: in vitro inhibition of α isoforms (hCA I, hCA II, bCA III, hCA IV) by flavonoids

A series of flavonoids, such as quercetin, catechin, apigenin, luteolin, morin, were investigated for their inhibitory effects against the metalloenzyme carbonic anhydrase (CA). The compounds were tested against four α-CA isozymes purified from human and bovine (hCA I, hCA II, bCA III, hCA IV) tissues. The four isozymes showed quite diverse inhibition profiles with these compounds. The flavonoids inhibited hCA I with KI-s in the range of 2.2–12.8 μM, hCA II with KI-s in the range of 0.74–6.2 μM, bCA III with KI-s in the range of 2.2–21.3 μM, and hCA IV with inhibition constants in the range of 4.4–15.7, with an esterase assay using 4-nitrophenyl acetate as substrate. Some simple phenols/sulfonamides were also investigated as standard inhibitors. The flavonoids incorporate phenol moieties which inhibit these CAs through a diverse, not yet determined inhibition mechanism, compared to classic inhibitors such as the sulfonamide/sulfamate ones.
An In Vitro Rapid-Turnover Assay for Human Immunodeficiency Virus Type 1 Replication Selects for Cell-to-Cell Spread of Virus

ABSTRACT We have developed a rapid-turnover culture system where the life span of a human immunodeficiency virus type 1-infected cell is controlled by periodic addition of a cytotoxic agent, mitomycin C. These mitomycin C-exposed cells are cocultured with a constant number of uninfected cells as new targets for the virus. Passage of the virus-infected cells under these conditions led to the emergence of a viral variant that was able to replicate efficiently in this culture system. After biologic and molecular cloning, we were able to identify a single frameshift mutation in the vpu open reading frame that was sufficient for growth of the mutant virus in the rapid-turnover assay. This virus variant spread more efficiently by cell-to-cell transfer than the parental virus did. Electron micrographs of cells infected with the Δvpu virus revealed a large number of mature viral capsids attached to the plasma membrane. The presence of these mature virus particles on the cell surface led to enhanced fusion and formation of giant syncytia with uninfected cells. Enhanced cell-to-cell transfer of the Δvpu virus provides an explanation for the survival of this mutant virus in the rapid-turnover culture system. The in vitro rapid-turnover culture system is a good representation of the in vivo turnover kinetics of infected cells and their continual replacement by host lymphopoietic mechanisms.
Species limits in Rhizobium populations that nodulate the common bean (Phaseolus vulgaris)

Evolutionary genetic relationships among 146 bean-nodulating Rhizobium strains, including 94 field isolates from three localities in Colombia and 36 strains from Mexico, were examined by multilocus enzyme electrophoresis and restriction fragment length polymorphism analysis of a PCR-amplified 260-bp segment of the 16S rRNA gene. Seventy-five electrophoretic types (ETs), corresponding to multilocus enzyme genotypes, were identified, including a genotypically diverse group of 18 ETs in Colombia that is strongly differentiated from the ETs of R. etli, which occur in Mexico, Colombia, and Brazil. Most strains of the distinctive Colombian ETs carried the same 16S rRNA allele as did strains of R. etli, but, surprisingly, 17 isolates of two of these ETs had the allele that is characteristic of R. leguminosarum, and strains of two other divergent groups of ETs were also polymorphic for the two alleles. No fully satisfactory explanation for the occurrence of the R. leguminosarum 16S rRNA allele in three distantly related groups of strains is available, but horizontal transfer and recombination of the gene, in whole or in part, would seem to be more plausible than convergence in nucleotide sequence.
Prediction of drug-related problems in diabetic outpatients in a number of hospitals, using a modeling approach

Objective Drug-related problems (DRPs) are considered a serious, expensive, and important undesirable complication of health care. However, as current health care resources are limited, pharmacist DRP services cannot be provided to all patients. Using a modeling approach, we aimed to identify risk factors for DRPs so that patients for DRP-reduction services can be better identified. Methods Patients with diabetes from outpatient clinics from five key university-affiliated and public hospitals in Jordan were assessed for DRPs (drug without an indication, untreated indication, and drug efficacy problems). Potential risk factors for DRPs were assessed. A logistic regression model was used to identify risk factors using a randomly selected, independent, nonoverlapping development (75%) subsample from full dataset. The remaining validation subsample (25%) was reserved to assess the discriminative ability of the model. Results A total of 1,494 patients were recruited. Of them, 81.2% had at least one DRP. Using the development subsample (n=1,085), independent risk factors for DRPs identified were male gender, number of medications, prescribed gastrointestinal medication, and nonadherence to self-care and non-pharmacological recommendations. Validation results (n=403) showed an area under the receiver operating characteristic curve of 0.679 (95% confidence interval=0.629–0.720); the model sensitivity and specificity values were 65.4% and 63.0%, respectively. Conclusion Within the outpatient setting, the results of this study predicted DRPs with acceptable accuracy and validity. Such an approach will help in identifying patients needing pharmacist DRP services, which is an important first step in appropriate intervention to address DRPs.