Miracle-dz/UniFAR-FTUs huggingface dataset:
Peroxidase isozyme polymorphism in popular sugarcane cultivars

Peroxidase isozyme was used to identify the variation among popular sugarcane cultivars of South India including the somaclones developed against biotic and abiotic stress tolerance. Electrophoretic polymorphism was surveyed for 12 diverse sugarcane cultivars and 11 somaclones. A total of 145 bands were scored with an average of 6.3 bands per cultivar. Presence of more number of isozymes reflected the genetic complexity of the genus Saccharum, a polyploidy of the tribe Andropogoneae. Variation in some of the somaclones was observed, but it was less polymorphic compared to other sugarcane cultivars studied. Peroxidase isozyme diversity among these variants in terms of similarity indices may be useful in identifying diverse cross-combinations for deriving hybrids of sugarcane.
Discriminative stimulus effects of the mixed-opioid agonist/antagonist dezocine: cross-substitution by mu and delta opioid agonists.

The purpose of this investigation was to evaluate the discriminative stimulus effects of the mixed-opioid agonist/antagonist dezocine. In pigeons trained to discriminate 1.7 mg/kg dezocine from saline, a series of opioids with activity at the mu opioid receptor substituted completely for the dezocine stimulus with a rank order of potency similar to that obtained in other assays sensitive to the effects of mu agonists (i.e., fentanyl >[-]-cyclazocine >buprenorphine = butorphanol >l-methadone >nalbuphine >[-]-metazocine >morphine). (-)-N-allylnormetazocine and (+)-propoxyphene substituted partially for the dezocine stimulus, an effect obtained even when tested up to doses that suppressed responding. Naloxone (0.1 - 10 mg/kg) antagonized the stimulus effects of dezocine, (+)-propoxyphene and fentanyl in a dose-related manner, whereas doses of naloxone that antagonized fentanyl's rate-decreasing effects failed to antagonize the rate-decreasing effects of dezocine and (+)-propoxyphene. A 10-mg/kg dose of the mu-selective, noncompetitive antagonist beta-funaltrexamine was more effective against the stimulus effects of dezocine and nalbuphine than against morphine and fentanyl. As was observed with naloxone, beta-funaltrexamine failed to antagonize dezocine's rate-decreasing effects. The delta agonists BW373U86 and SNC80 substituted partially for the dezocine stimulus, and these effects were reversed by doses of the delta-selective antagonist naltrindole (0.1 and 1.0 mg/kg) that had no effect on the dezocine stimulus. Naltrindole also antagonized the rate-decreasing effects produced by BW373U86 and SNC80, but not those of dezocine. The kappa agonists bremazocine, spiradoline, U50,488 and U69,593 failed to substitute for the dezocine stimulus. The kappa-selective antagonist norbinaltorphimine (1.0 mg/kg) failed to antagonize dezocine's stimulus or rate-decreasing effects. The present findings indicate that dezocine shares similar stimulus effects with both mu and delta agonists, its stimulus effects are reversed by mu-selective antagonists, and its rate-decreasing effects are not mediated by activity at mu, kappa or delta opioid receptors.
Sublingual Hematoma Linked to Uncontrolled Warfarin Use: A Case Report

Anticoagulant treatment is a vital treatment method used in prophylaxis and treatment of tromboembolic diseases. In anticoagulant treatment, the most significant complication that can sometimes threaten patient’s life is hemorrhage. Therefore, planning anticoagulant treatment in a way not to cause thrombosis or bleeding and meticulous clinical and laboratory follow-up is vital. Hemorrhage in sublingual area is very rare. However, warfarin related bleeding in this area is life threatening and it might require securing patient's airway. In its treatment, it is recommended that anticoagulation with vitamin K, pro-thrombin complex concentrate (PCC) and fresh frozen plasma (FFP) be reversed immediately. In this article, a case who developed sublingual hemorrhage caused by prophylactic warfarin intake due to Coronary Artery Bypass Graft (CABG) has been presented.
Vocabulary Image Captioning with Constrained Beam Search

Existing image captioning models do not generalize well to out-of-domain images containing novel scenes or objects. This limitation severely hinders the use of these models in real world applications dealing with images in the wild. We address this problem using a flexible approach that enables existing deep captioning architectures to take advantage of image taggers at test time, without re-training. Our method uses constrained beam search to force the inclusion of selected tag words in the output, and fixed, pretrained word embeddings to facilitate vocabulary expansion to previously unseen tag words. Using this approach we achieve state of the art results for out-of-domain captioning on MSCOCO (and improved results for in-domain captioning). Perhaps surprisingly, our results significantly outperform approaches that incorporate the same tag predictions into the learning algorithm. We also show that we can significantly improve the quality of generated ImageNet captions by leveraging ground-truth labels.
When hearing turns into playing: Movement induction by auditory stimuli in pianists

In this study, pianists were tested for learned associations between actions (movements on the piano) and their perceivable sensory effects (piano tones). Actions were examined that required the playing of two-tone sequences (intervals) in a four-choice paradigm. In Experiment 1, the intervals to be played were denoted by visual note stimuli. Concurrently with these imperative stimuli, task-irrelevant auditory distractor intervals were presented (“potential” action effects, congruent or incongruent). In Experiment 2, imperative stimuli were coloured squares, in order to exclude possible influences of spatial relationships of notes, responses, and auditory stimuli. In both experiments responses in the incongruent conditions were slower than those in the congruent conditions. Also, heard intervals actually “induced” false responses. The reaction time effects were more pronounced in Experiment 2. In nonmusicians (Experiment 3), no evidence for interference could be observed. Thus, our results show that in expert pianists potential action effects are able to induce corresponding actions, which demonstrates the existence of acquired action–effect associations in pianists.
Understanding and engaging families: An education, skills and support program for relatives impacted by borderline personality disorder

Background: Few methodologically sound studies have been conducted to facilitate the understanding of relationships in families with a member suffering from severe personality disorders. Because of severity, symptomatology, and high rates of co-occurring disorders, borderline personality disorder (BPD) particularly affects family members and others in their social environment. However, there are few interventions available to address the needs of these family members. Aim: To report on a replication and extension study of ©Family Connections (FC), a 12-week community-based BPD education program for family members. Method: FC participants (N = 55) were assessed pre, post and at 3-month post program follow-up on: (i) levels of change in family well-being outcomes: burden, grief and empowerment; and (ii) differences between male and female participants in these outcomes. Results: Findings from the original FC study were replicated and extended: Participants showed significant improvements on all well-being variables, including significant reductions in depression. Outcomes for male vs. female participants were comparable at program completion except for grief, on which women remained higher than men despite significant improvements for both. Conclusion: BPD family members experience significant distress but benefited from this semi-structured group program led by family members. Findings support the use of the FC program. Declaration of interest: None.
Conservation of sequence and function between the product of the 52-kilodalton immediate-early gene of herpesvirus saimiri and the BMLF1-encoded transcriptional effector (EB2) of Epstein-Barr virus

We present a sequence of 2,220 nucleotides from a region of the genome of herpesvirus saimiri (HVS) which includes the coding and putative regulatory sequences for the 52-kilodalton (kDa) immediate-early (IE) phosphoprotein of the virus. The amino acid sequence predicted for this protein shows it to be homologous to the EB2 transcriptional effector encoded by the BMLF1 open reading frame of Epstein-Barr virus (EBV), the IE 68-kDa protein of varicella-zoster virus, and the IE 63-kDa (alpha 27) protein of herpes simplex virus (HSV). By measuring the function of the HVS 52-kDa-protein gene in transient expression assays, we also showed that it can substitute with comparable efficiency for the EB2 product of EBV in the EB1-dependent activation of the EBV DR promoter. The alpha 27 gene of HSV was an inefficient trans-activator in similar assays. We conclude that the IE 52-kDa protein of HVS is structurally and functionally more similar to the homologous protein of the human lymphotropic virus, EBV, than to the corresponding proteins from the neurotropic viruses, varicella-zoster virus and HSV.
TA-periodic (“601”-like) centromeric nucleosomes of A. thaliana

The bulk of strong nucleosomes (SNs, with visibly periodic DNA sequences) is described by consensus pattern of 5 or 6 base runs of purines alternating with similar runs of pyrimidines – RR/YY SNs. Yet, the strongest known nucleosome positioning sequence, the 601 clone of Lowary and Widom, is rather periodic repetition of TA dinucleotides following one another every 10 bases. We located “601”-like TA-periodic sequences in the genome of A. thaliana. Several families of such sequences are discovered repeating almost exclusively in centromeres. Thus, while A. thaliana SNs of RR/YY type have strong affinity to pericentromeric regions, as it has been previously found, the SNs of TA periodic type concentrate rather in centromeres.
Evaluation of type 2 diabetes mellitus medication management and control in older adults.

OBJECTIVES The primary aims of this study were to characterize glycemic control and pharmacologic management in older patients and to compare glycemic control and pharmacological management in patients 65 to 79 years of age ("young-old") with those 80 to 89 years of age ("old-old"). We hypothesized that patients 80 to 89 years of age would be prescribed fewer medications and would have higher A1c values compared with younger patients. DESIGN Retrospective medical record review. SETTING This study was conducted in outpatient clinics within a university hospital setting. PATIENTS, PARTICIPANTS This study included 400 adults 65 to 89 years of age with a diagnosis of type 2 diabetes mellitus and at least one A1c measurement over 12 months. MAIN OUTCOME MEASURES A1c measurements and diabetes mellitus medications were assessed in these patients. RESULTS The overall mean A1c was similar in the young-old compared with the old-old (7.1 ± 1.1% vs. 7.0 ± 1.1%; P = NS). There was no difference between groups for any of the A1c ranges studied. Fewer diabetes medications were prescribed in the old-old compared with the young-old (P = 0.003). In the young-old compared with the old-old, metformin (51.0% vs. 33.0%; P < 0.01), glucagon-like peptide-1 agonists (6.7% vs. 0%; P < 0.01), insulin glargine/detemir (24.7% vs. 13.0%; P < 0.05), and short-acting insulin (15.0% vs. 7.0%; P < 0.05) were more frequently prescribed. CONCLUSION Our results indicate that glycemic control was similar between the young-old and old-old. However, the old-old required fewer diabetic medications for this same level of glycemic control.
How are we using systemic drugs to treat psoriasis in children? An insight into current clinical U.K. practice

there was no sign of recurrence at 12 months. Until recently, memory T-cell populations have been categorized as central memory T (TCM) cells, which coexpress CCR7 and CD62L, and effector memory T (TEM) cells, which do not express these molecules. TCM cells are restricted to secondary lymphoid organs and blood, whereas TEM cells circulate between peripheral tissues, blood and the spleen. Recent studies have identified that a third subset of memory T cells, TRM cells, permanently reside in peripheral tissues. The best characterized are CD8 TRM cells that express CD103 and CD69 but stain negative for CCR7 and CD62L, and may provide sitespecific protection against pathogen re-exposure. These cells are sequestered in the skin epidermis and do not recirculate. In contrast, memory CD4 T cells that presumably belong to TEM cells are found within the dermis and at least a proportion of these cells are capable of recirculating. A recent study showed that mycosis fungoides arises from skin-resident CD4 TEM cells, whereas S ezary syndrome arises from CD4 TCM cells. 6 Most CTCLs derive from CD4 T cells, and CD8 CTCLs occur infrequently. With respect to PTCL-NOS, Bekkenk et al. demonstrated that four of 19 cases originated from CD8 T cells. Although PTCL-NOS is considered to have a poor prognosis, several CD8 PTCL-NOS cases exhibiting indolent clinical behaviour without systemic disease have been reported, including a case of CD8 PTCL-NOS in an 18-year-old woman, which we previously reported. No detailed analysis was performed in the cases reported by Khamaysi et al. and Kempf et al., whereas the tumour cells reported by Rosmaninho et al. exhibited abCD3CD8CD27 phenotype, and our case exhibited abCD3CD8CD45RO memory phenotype. As a detailed analysis using the markers for TRM cells was not performed in these cases, it is uncertain whether they are identical to those in the case of CD8 PTCL-NOS in the 96-year-old man reported above. Whether this case should be considered a specific entity of CTCL is currently unknown. However, a distinct set of markers specific for CD8 TRM cells expressed by the tumour cells in this case suggest that there may be a distinct entity of CD8 peripheral T-cell lymphoma, presumably of TRM origin, which may be limited to skin without extracutaneous involvement. Further cases with detailed analyses are needed to confirm this hypothesis.
Reasons to love life. Effects of a suicide-awareness campaign on the utilization of a telephone emergency line in Austria.

BACKGROUND A suicide awareness campaign was initiated in the Austrian federal state of Styria to increase help-seeking behavior in the population. Billboards were shown throughout Styria depicting joyful everyday-life situations with a focus on social and family connectedness, and promoting the Telephone Emergency Service, a crisis hotline. AIMS The present study investigated the impact of this campaign on the utilization of the crisis hotline and on suicide rates. METHOD Phone calls and suicide rates in the study region 3 months before the campaign were compared with rates 3 months after the campaign. The changes were contrasted with the characteristics of phone calls and the suicide rate in a comparable control region. RESULTS There were significantly more phone calls in the study region after the awareness campaign compared to the control region, which was similar to seasonal trends in nonintervention years, and there was no increase of suicide-related phone calls. The proportion of suicide-related phone calls referring to family problems decreased after the initiation of the campaign. Suicide rates did not change. CONCLUSION The campaign may have had some minor immediate impact on the utilization of the Telephone Emergency Service, but it did not seem to motivate suicidal individuals, especially those with family problems, to call.
Making Sense in a Fragmentary World

The communicative capabilities of people with autism are impaired and limited in significant ways. The problems are characterized by a lack of intentionality and symbol formation, which indicates that the deviant development of communication in autism is associated with a specific cognitive style. The central coherence theory can offer insight into the specific communication problems of people with autism, since a weaker drive for central coherence leads to problems in sense-making and, consequently, in communication. In the case of the comorbidity of autism and learning disability, the communication problems are aggravated. The crucial point is the determination of the level of sense-making, taking this comorbidity into account. Assessment and intervention have to be tuned to individual needs, in order to increase the communicative competence of people with autism and learning disability.
A DPA-resistant crypto engine for UHF RFID tag

Differential power analysis (DPA) is a potential threat to the security of radio frequency identification (RFID) system. In this paper, the hardware implementation of a DPA-resistant crypto engine for RFID tag conforming to ISO/IEC 18000-63 protocol is presented. The masking scheme is adopted in the AES crypto engine to protect the tag from DPA attacks. The design is implemented using 0.13 µm CMOS technology. According to simulation results, the DPA-resistant crypto engine occupies 38% more area and consumes 20% more power than the unmasked one. The area of the whole tag baseband including the DPA-resistant crypto engine is about 163,000 µm². The average power consumption during a query round is 21.2 µW under 1 V voltage and 1.28 MHz clock frequency.
A behavioral theory of alliance portfolio reconfiguration: Evidence from pharmaceutical biotechnology

Research summary: Extant research suggests that firms rationally evaluate external and/or internal contingencies when deciding how to reconfigure their alliance portfolios. We advance a behavioral perspective which assumes that managers are boundedly rational and thus rely on behavioral heuristics when making alliance portfolio reconfiguration decisions. In panel data on U.S.-listed biotechnology firms, we find that below-aspiration performance motivates a firm to form alliances with novel partners within the resource scope of its existing alliance portfolio. This effect is weakened by equity ties with existing partners and strengthened by firm-specific uncertainty. Conversely, above-aspiration performance leads to new alliances with existing partners but outside the resource scope of the firm’s existing alliance portfolio. Finally, as organizational slack increases, a firm forms alliances with novel partners focusing on new-to-the-portfolio resources. Managerial summary: We study why and how firms change the configuration of their alliance portfolios over time. We find that actual performance relative to performance objectives, and firms’ excess resources, are important drivers of such change. The more firms fail to meet their performance objectives, the more likely they are to form alliances with novel partners focusing on areas in which they already have one or more alliances with other partners. The more firms exceed their performance objectives, the greater their inclination to form alliances with their existing partners in areas in which they do not yet have alliances. The greater the stock of excess resources, the greater firms’ propensities to form alliances with novel partners focusing on areas in which they do not yet have alliances.
Male circumcision, penile human papillomavirus infection, and cervical cancer in female partners.

BACKGROUND It is uncertain whether male circumcision reduces the risks of penile human papillomavirus (HPV) infection in the man and of cervical cancer in his female partner. METHODS We pooled data on 1913 couples enrolled in one of seven case-control studies of cervical carcinoma in situ and cervical cancer in five countries. Circumcision status was self-reported, and the accuracy of the data was confirmed by physical examination at three study sites. The presence or absence of penile HPV DNA was assessed by a polymerase-chain-reaction assay in 1520 men and yielded a valid result in the case of 1139 men (74.9 percent). RESULTS Penile HPV was detected in 166 of the 847 uncircumcised men (19.6 percent) and in 16 of the 292 circumcised men (5.5 percent). After adjustment for age at first intercourse, lifetime number of sexual partners, and other potential confounders, circumcised men were less likely than uncircumcised men to have HPV infection (odds ratio, 0.37; 95 percent confidence interval, 0.16 to 0.85). Monogamous women whose male partners had six or more sexual partners and were circumcised had a lower risk of cervical cancer than women whose partners were uncircumcised (adjusted odds ratio, 0.42; 95 percent confidence interval, 0.23 to 0.79). Results were similar in the subgroup of men in whom circumcision was confirmed by medical examination. CONCLUSIONS Male circumcision is associated with a reduced risk of penile HPV infection and, in the case of men with a history of multiple sexual partners, a reduced risk of cervical cancer in their current female partners.
Demonstration of cell division by septation in a variety of gram-negative rods

Through use of an initial fixative employing a combination of crotonaldehyde and glutaraldehyde, septa were preserved in thin sections of dividing cells of strains of Pseudomonas aeruginosa, Salmonella typhimurium, Shigella sonnei, and Escherichia coli when grown at 30 C in a dilute basal medium. The same procedures, however, revealed only a constrictive division process in Proteus vulgaris and Erwinia sp. This adds to the evidence that septation, although difficult to demonstrate, is the process of cell division in the enteric gram-negative rods and the pseudomonads and that constriction is a fixation artifact in these organisms.
Pengaruh Jumlah Kunjungan Wisatawan, Lama Tinggal Wisatawan dan Tingkat Hunian Hotel terhadap Pendapatan Asli Daerah dan Kesejahteraan Masyarakat pada Kabupaten/Kota di Provinsi Bali

Bali Province is a that rely on tourism sector as a source of revenue contribute large enough on local revenue and public welfare. The purpose of this research is to analyze the number of tourist visit, remained tourists, and occupancy rate for hotels to community welfare by regional real income on regency/city in Bali Provinces. This reasearch used secondary data the data time series beginning in 2010 - 2015. Data collection is done through observation on publication of the BPS Bali Provinces and of Tourism Bali Province. Analysis techniques that used path analysis. Based on analysis of the obtained the result that the number of visits tourists and occupancy rate for hotels have had a positive impact and significant on local revenue, while remained tourists no effect on local revenue in districts in Bali province. The number of tourist visits, remained tourists, occupancy rate for hotels have had a positive impact and significant in community welfare, while local revenue no effect on the welfare of the community in districts in Bali Province. Local revenue as variable mediation relations the number of tourist visits, remained tourists and occupancy rate for hotels influential in community welfare.