Miracle-dz/UniFAR-FTUs huggingface dataset:
Evidence of transcription from the late region of the integrated simian virus 40 genome in transformed cells: location of the 5' ends of late transcripts in cells abortively infected and in cells transformed by simian virus 40

By means of S1 mapping, we observed that spliced 16S and 19S viral late mRNAs--in addition to early mRNAs--were present in cytoplasmic polyadenylated RNA preparations from simian virus 40-transformed cell lines of rat or mouse origin containing no detectable amount of free viral DNA. The amounts of early and late virus-specific mRNAs in these lines were quantified by hybridization of radioactive cytoplasmic polyadenylated RNA with cloned region-specific restriction fragments. The relative amount of late viral mRNA produced in these transformed cells was found to be of the same order as that produced in simian virus 40-infected, nonpermissive baby mouse kidney cells. Moreover, by using the S1 nuclease protection method, we compared the 5' ends of late mRNAs produced (i) in transformed cells, (ii) in abortively infected mouse cells, and (iii) in the late phase of the lytic cycle. The 5' ends of late mRNAs both in abortively infected and in transformed cells were less heterogeneous than the 5' ends of late mRNAs produced during the lytic cycle; however, they were a subset of the 5' ends of late transcripts produced in the lytic cycle.
The impact of physical therapy on functional outcomes after stroke : what ’ s the evidence ?

RPS Van Peppen Department of Physical Therapy, VU University Medical Center, Amsterdam, G Kwakkel Department of Physical Therapy, VU University Medical Center, Amsterdam and Center of Excellence for Rehabilitation Medicine ‘de Hoogstraat’, Utrecht, The Netherlands, S Wood-Dauphinee School of Physical and Occupational Therapy, Department of Epidemiology and Biostatistics, McGill University, Montreal, Canada, HJM Hendriks Dutch Institute of Allied Health Care (Npi), Amersfoort and Maastricht University, Department of Epidemiology, Maastricht, PhJ Van der Wees Royal Dutch Society for Physical Therapy (KNGF), Amersfoort and J Dekker Institute for Research in Extramural Medicine (EMGO Institute), Department of Rehabilitation Medicine, VU University Medical Center, Amsterdam, The Netherlands
The effectiveness of psychodynamic therapy and cognitive behavior therapy in the treatment of personality disorders: a meta-analysis.

OBJECTIVE The authors conducted a meta-analysis to address the effectiveness of psychodynamic therapy and cognitive behavior therapy in the treatment of personality disorders. METHOD Studies of psychodynamic therapy and cognitive behavior therapy that were published between 1974 and 2001 were collected. Only studies that 1) used standardized methods to diagnose personality disorders, 2) applied reliable and valid instruments for the assessment of outcome, and 3) reported data that allowed calculation of within-group effect sizes or assessment of personality disorder recovery rates were included. Fourteen studies of psychodynamic therapy and 11 studies of cognitive behavior therapy were included. RESULTS Psychodynamic therapy yielded a large overall effect size (1.46), with effect sizes of 1.08 found for self-report measures and 1.79 for observer-rated measures. For cognitive behavior therapy, the corresponding values were 1.00, 1.20, and 0.87. For more specific measures of personality disorder pathology, a large overall effect size (1.56) was seen for psychodynamic therapy. Two cognitive behavior therapy studies reported significant effects for more specific measures of personality disorder pathology. For psychodynamic therapy, the effect sizes indicate long-term rather than short-term change in personality disorders. CONCLUSIONS There is evidence that both psychodynamic therapy and cognitive behavior therapy are effective treatments of personality disorders. Since the number of studies that could be included in this meta-analysis was limited, the conclusions that can be drawn are only preliminary. Further studies are necessary that examine specific forms of psychotherapy for specific types of personality disorders and that use measures of core psychopathology. Both longer treatments and follow-up studies should be included.
Properties of Spray Pyrolysied Copper Oxide Thin Films

Copper oxide (CuO) thin films were deposited on well cleaned glass substrates by spray pyrolysis technique (SPT) from cupric acetate (Cu(CH3COO)2.H2O) precursor solutions of 0.05 – 0.15 M molar concentrations (MC) at a substrate temperature of 350 °C and at an air pressure of 1 bar. Effect of varying MC on the surface morphology, structu6ral optical and electrical properties of CuO thin films were investigated. XRD patterns of the prepared films revealed the formation of CuO thin films having monoclinic structure with the main CuO (111) orientation and crystalline size ranging from 8.02 to 9.05 nm was observed. The optical transmission of the film was found to decrease with the increase of MC. The optical band gap of the thin films for 0.10 M was fond to be 1.60 eV. The room temperature electrical resistivity varies from 31 and 24 ohm.cm for the films grown with MC of 0.05 and 0.10 M respectively. The change in resistivity of the films was studied with respect to the change in temperature was shown that semiconductor nature is present. This information is expected to underlie the successful development of CuO films for solar windows and other semi-conductor applications including gas sensors.
Management of advanced cervical metastasis using intraoperative radiotherapy

Seventy‐five patients who had advanced cervical metastasis with possible invasion of the deep muscles or carotid artery were approached with aggressive resection and intraoperative radiotherapy (IORT). All metastatic nodes were greater than 3 cm, 65% were fixed on clinical examination, and 35% involved the carotid artery. Forty‐six (61%) of the patients had previously received irradiation. Fifteen of the patients required extended neck dissections with carotid resections and grafting. After the resection an average single dose of 2000 cGy of electron beam IORT was delivered.
Hispanic Intermarriage in New York City: New Evidence from 1991 1

This study replicates research on Hispanic intermarriage by Fitzpatrick (1966) and Gurak and Fitzpatrick (1982) using 1991 marriage records from New York City. It examines trends in marital assimilation among Puerto Ricans and the non-Puerto Rican Hispanic population. The prevalence of intermarriage varies among the six Hispanic national-origin groups. Changes in intermarriage patterns since 1975 are documented. Results show very high rates of intermarriage with non-Hispanics among Cubans, Mexicans, Central Americans, and South Americans. Considerable intermarriage among Hispanics of different national origins is characteristic of all Hispanics. Finally, Puerto Ricans and Dominicans have distinct patterns of intermarriage, characterized by high rates of intermarriage with each other, lower rates of intermarriage with non-Hispanics, no intergenerational increase in exogamy, and higher rates of nonmixed ancestry among the second generation. Implications of these trends are discussed.
Inherited Thrombocytopenias with Predisposition the Hematological Malignancies

Inherited thrombocytopenias (IT) are rare, clinically and genetically heterogeneous diseases caused by mutations in more than 30 genes. Mutations of three of these genes, RUNX1, ANKRD26, and ETV6, cause Familial Platelet Disorder with propensity to Acute Myelogenous Leukemia (FPD/AML), ANKRD26-related thrombocytopenia (ANKRD26-RT), and ETV6-related thrombocytopenia (ETV6-RT), respectively. They are similar forms characterized by moderate thrombocytopenia with platelets of normal size. In addition to mild bleeding tendency, individuals affected with these forms of IT have an increased risk of developing hematological neoplasms, including myelodysplastic syndrome, acute myeloid leukemia, and acute lymphoblastic leukemia. The pathogenic mechanisms responsible for these ITs are partially known, likely resulting in defects of a pathway controlling the expression of ANKRD26 in hematopoietic cells. Due to their rarity, FPD/AML, ANKRD26RT, and ETV6-RT are still poorly defined diseases, requiring extensive genetic analysis and clinical characterization. Considering the increased risk of leukemia, improvement of our knowledge of these ITs would be of fundamental importance in recognizing affected individuals.
Dasatinib treatment for Philadelphia chromosome‐positive leukemias

Dasatinib is a highly potent Bcr‐Abl inhibitor that is approved for the treatment of imatinib‐resistant or ‐intolerant chronic myeloid leukemia (CML) and Philadelphia chromosome‐positive acute lymphoblastic leukemia. Across a series of phase 2 and 3 trials, dasatinib was associated with durable treatment responses in all phases of the disease and was well tolerated. For this article, the authors reviewed available information on specific side effects associated with the use of dasatinib. On the basis of more than 2 years' experience of dasatinib treatment during clinical trials, they provide practical recommendations for side‐effect management. Cancer 2009. © 2009 American Cancer Society.
Bilateral peroneal spastic flat feet associated with congenital fusion of the navicular and talus. A case report.

Ainonnalies of the tan-sal bones am-c quite fn-eqnmenmt. Since I 948, when Han-n-is arid Beath first stressed the significance of these annomnnalies inn the c’aimsationi (If symptoinnatic flat feet, miunncm-ous articles 3,5,6,7,8 have appeaned inn which the various annornalies-oSseous, fibrous, arid cartilaginous, eitherpartial om (‘onnplctc-werc descrihed amid the symnnptonns amid significance dis(’uisse(l. The case t(I be reporte(1 desen-ibes a patient with bilateral talonmavidulan fusion
Inferring Work Task Automatability from AI Expert Evidence

Despite growing alarm about machine learning technologies automating jobs, there is little good evidence on what activities can be automated using such technologies. We contribute the first dataset of its kind by surveying over 150 top academics and industry experts in machine learning, robotics and AI, receiving over 4,500 ratings of how automatable specific tasks are today. We present a probabilistic machine learning model to learn the patterns connecting expert estimates of task automatability and the skills, knowledge and abilities required to perform those tasks. Our model infers the automatability of over 2,000 work activities, and we show how automation differs across types of activities and types of occupations. Sensitivity analysis identifies the specific skills, knowledge and abilities of activities that drive higher or lower automatability. We provide quantitative evidence of what is perceived to be automatable using the state-of-the-art in machine learning technology. We consider the societal impacts of these results and of task-level approaches.
Serum Nitric Oxide and Glutathione Levels in Preeclamptic and Normotensive Women during Labor

This study was performed on 38 preeclamptic women, including 26 severely preeclamptic and eclamptic cases, as well as 50 normotensive pregnant controls. Twenty cases in the preeclamptic group and 34 cases in the control group were in labor. Serum nitric oxide levels were measured as total nitrites after reduction of nitrates to nitrites. Among the control subjects, nitric oxide levels were significantly lower in the cases in labor when compared to those not in labor (p < 0.05), but glutathione levels were not significantly different (p >0.05). Among the preeclamptic patients, although nitric oxide levels were not significantly different between the cases in and not in labor (p > 0.05), glutathione levels were significantly higher in the latter group (p < 0.05). Thus, in preeclamptic patients there might be a compensatory increase in nitric oxide production during labor in order to maintain the systemic circulation. Glutathione levels might also be increased to compensate for the marked oxidative stress.
COMPARATIVE PERFORMANCE OF DIFFERENT VARIETIES OF CHICKEN UNDER BACKYARD SYSTEM OF REARING IN TRIBAL AND RURAL AREAS OF WEST GODAVARI DISTRICT ,

Rural families rear Desi type chicken with low egg and meat production in backyard system. For developing the rural poultry farming, improved backyard poultry birds rearing is of utmost important. These improved birds can rear in both intensive and free ranging system. The growth and production performance of three chicken varieties were evaluated in the present study by KVK, Venkataramannagudem in rural and tribal areas. 1500 birds of these three breeds were supplied to rural and tribal families as demonstration and for nutritional security among the rural and tribal families during 2014-15 and 2015-16. The body weights were significantly varied in Vanaraja, Gramapriya and Aseel chicken varieties. The body weights were significantly higher in Vanaraja and Gramapriya than Aseel chicken. The comparative estimate of egg production revealed that egg production for Gramapriya is comparatively higher than Vanaraja followed by Aseel chicken. Performance of Vanaraja and Gramapriya under tropical condition of the West Godavari was found satisfactory and the birds are well adapted to local agro-climatic condition under free range system of production. The backyard poultry farming with improved birds provide a solution to food security to the needy villagers paving a way for sustainable livestock in rural areas of India.
Emotional and Behavioral Characteristics Over a Six-Year Period in Youths With Persistent and Nonpersistent Dyscalculia

The authors examined behavior problems in a matched sample of 58 youths with persistent dyscalculia (PD) and nonpersistent dyscalculia (NPD). Participants were classified as having dyscalculia at age 10—11 years. Parents completed the Child Behavior Checklist for their children at ages 10—11, 13—14, and 16—17 years, while the youths did so at the last two age periods. Only at age 16—17 years were there significantly more problems, particularly attention problems and externalizing problems, reported by parents for PD youths compared to NPD youths. A higher percentage in the PD group than in the NPD group received scores in the clinical range for externalizing problems. However, the mean levels of behavior problems at this age and the earlier ages were within the normal range for both groups. For youth-reported problems, the only significant difference was for attention problems at 16—17 years. Therapeutic interventions should focus on the academic domain and improving and altering behavioral patterns.
Numerical Simulation and Experimental Study for Magnetic Pulse Welding Process on AA 6061-T 6 and Cu 101 Sheet

Magnetic Pulse Welding (MPW) is a collision welding process, similar to Explosive/impact Welding (EXW), but it utilizes electromagnetic force as the acceleration mechanism. Therefore, the available energy is much lower than EXW and it makes the process safer and more reproducible for sheet seam welding. However, the available energy must be better focused and controlled. In the sheet seam MPW process, a flyer sheet is driven and collides with a target sheet. True metallic bonding is achieved at the mating interface if contact takes place above a critical impact velocity at an appropriate impact angle. The impact velocity and angle are determined by the primary and induced electromagnetic fields. Both of them are strongly related to the geometry of the electromagnetic actuator and the discharge characteristics. An MPW launch system that will robustly provide bonding can either be developed empirically or through simulation. Here we attempt to provide the basis for a simulation-based approach to system design. The oblique MPW impact of AA606-T61 and Cu101 were analyzed using the newly available Electromagnetism (EM) module in LS-DYNA. This module allows performing coupled mechanical/thermal/electromagnetic simulations. The simulation can predict the impact velocities and the temperature distribution along the mating interface. The simulation results were validated with measurement by Photon Doppler Velocimetry (PDV) measurement. Additionally, the simulation results also indicated rapid thermal cycling on the mating interface.
Magnetostriction Measurement of a Ferromagnetic Thin Film Using Digital Holographic Microscope

Magnetostrictive Fe<sub>62</sub>Co<sub>19</sub>Ga<sub>19</sub> films deposited on Si(100) substrates were used as test samples in this paper: the length (L) is parallel to the x-axis and the width (w) parallel to the y-axis. The conventional magnetostriction measurement includes measuring the free end deflection (Δz) of the cantilevered film-substrate system as a function of the external field (H). In addition, we also used a digital holographic microscope (DHM) to map out the 2-D or 3-D magnetostriction deflection profile, i.e., the deflection, Δz, at any location (x, y) on the film plane, due to H<sub>∥</sub> (the longitudinal field) or H<sub>⊥</sub> (the transverse field). We have compared the saturation magnetostriction (λ<sub>s</sub>) data of the test samples, with different w/L ratios, measured by the conventional as well as the DHM method. There are three advantages of the DHM method. First, we could see the deflection motions directly. Second, we could examine the transverse-edge boundary effect on λ<sub>s</sub> of the test sample. Third, in agreement with the Saint-Venant's principle, we could study the effect of clamping on λ<sub>s</sub>.
Induction of type I interferon by adenovirus-encoded small RNAs

Transduction with replication-incompetent recombinant adenovirus (Ad) vectors results in a rapid activation of innate immune responses, such as inflammatory cytokine production and subsequent tissue damage. The precise mechanisms of the innate immune responses induced by Ad vectors remain to be clarified. Possible components of Ad vectors that activate innate immune responses are the capsid protein, the viral genome (DNA), and viral transcripts. In the present study, we demonstrate that virus-associated RNAs (VA-RNAs), which are small RNAs transcribed by RNA polymerase III, induce the production of type I IFN (IFN-α and IFN-β), but they do not induce the production of inflammatory cytokines (IL-6 and IL-12), in mouse embryonic fibroblasts (MEFs) and granulocyte-macrophage colony-stimulating factor–generated bone marrow-derived dendritic cells (GM-DCs). We also show that IFN-β promoter stimulator-1 is involved in VA-RNA–dependent IFN-β production in MEFs and is partially involved in type I IFN production in GM-DCs. This study provides important insight into the mechanisms of Ad vector-triggered innate immune responses, which may lead to more advanced and rational Ad vector designs for gene therapies and vaccine applications.
Variations in Orthotropic Elastic Constants of Green Chinese Larch from Pith to Sapwood

Full sets of elastic constants of green Chinese larch (Larix principis-rupprechtii Mayr) with 95% moisture content at four different cross-section sampling positions (from pith to sapwood) were determined in this work using three-point bending and compression tests. Variations in the material constants of green Chinese larch from pith to sapwood were investigated and analyzed. The results showed that the sensitivity of each elastic constant to the sampling position was different, and the coefficient of variation ranged from 4.3% to 48.7%. The Poisson’s ratios νRT measured at four different sampling positions were similar and the differences between them were not significant. The coefficient of variation for Poisson’s ratio νRT was only 4.3%. The four sampling positions had similar Poisson’s ratios νTL, though the coefficient of variation was 11.7%. The Poisson’s ratio νLT had the greatest variation in all elastic constants with a 48.7% coefficient of variation. A good linear relationship was observed between the longitudinal modulus of elastic EL, shear modulus of elasticity GRT, Poisson’s ratio νRT, and sampling distance. EL, GRT, and νRT all increased with sampling distance R. However, a quadratic relationship existed with the tangential modulus of elasticity ET, radial modulus of elasticity ER, shear modulus of elasticity GLT, and shear modulus of elasticity GLR. A discrete relationship was found in the other five Poisson’s ratios. The results of this study provide the factual changes in the elastic constants of green wood from pith to sapwood for numerical modelling of stress wave propagation in trees or logs.
Catheter-associated urinary tract infection in a surgical intensive care unit.

BACKGROUND/AIM Because patients in intensive care units usully have an urinary catheter, the risk of urinary tract infection for these patients is higher than in other patients. The aim of this study was to identify risk factors and causative microrganisms in patients with catheter-associated urinary tract infection (CAUTI) in the Surgical Intensive Care Unit (SICU) during a 6-year period. METHODS All data were collected during prospective surveillance conducted from 2006 to 2011 in the SICU, Military Medical Academy, Belgrade, Serbia. This case control study was performed in patients with nosocomial infections recorded during surveillance. The cases with CAUTIs were identified using the definition of the Center for Disease Control and Prevention. The control group consisted of patients with other nosocomial infections who did not fulfill criteria for CAUTIs according to case definition. Results. We surveyed 1,369 patients representing 13,761 patient days. There were a total of 226 patients with nosocomial infections in the SICU. Of these patients, 64 had CAUTIs as defined in this study, and 162 met the criteria for the control group. Multivariate logistic regression analysis identified two risk factors independently associated to CAUTIs: the duration of having an indwelling catheter (OR = 1.014; 95% CI 1.005-1.024; p = 0.003) and female gender (OR = 2.377; 95% CI 1.278-4.421; p = 0.006). Overall 71 pathogens were isolated from the urine culture of 64 patients with CAUTIs. Candida spp. (28.2%), Pseudomonas aeruginosa (18.3%) and Klebsiella spp. (15.5%) were the most frequently isolated microorganisms. CONCLUSIONS The risk factors and causative microrganisms considering CAUTIs in the SICU must be considered in of planning CAUTIs prevention in this setting.
Rise of circulating thrombopoietin following cardiothoracic surgery is potentiated in patients with coronary atherosclerosis: correlation with a preceding increase in levels of interleukin-6

Summary Thrombopoietin (TPO) is the major regulator of platelet production. Plasma levels of TPO are thought to be regulated by its binding to platelets and megakaryocytes. Here we have used a model of cardiac surgery with cardiopulmonary bypass (CBP) to test the possibility that changes in TPO levels are influenced by the presence of coronary artery disease (CAD) and by changes in interleukin-6 (IL-6). After surgery patients with CAD (n = 22) or with normal coronary arteries (n = 11) showed a significant thrombocytopaenia followed by a reactive thrombocytosis. The platelet recovery was preceded by a significant rise in TPO (from 62.6 ± 9.4 pg/ml at baseline to 129.2 ± 19 pg/ml at 60 h, P <0.001), which in turn was preceded by, and was positively correlated with, a marked increase in circulating IL-6 (from 1.5 ± 0.3 pg/ml at baseline to 269.3 ± 30.6 pg/ml at 3-12 h, P <0.001). The rise of both IL-6 and TPO was significantly larger in patients with CAD. No correlation was found between the post-operative drop in platelet mass and changes in either the TPO or IL-6 levels. These findings suggest that in man circulating TPO levels, besides being controlled by changes in platelet mass, are influenced by inflammatory processes, including the presence of coronary atherosclerosis.