Miracle-dz/UniFAR-FTUs huggingface dataset:
TenniSet: A Dataset for Dense Fine-Grained Event Recognition, Localisation and Description

This paper introduces a new video understanding dataset which can be utilised for the related problems of event recognition, localisation and description in video. Our dataset consists of dense, well structured event annotations in untrimmed video of tennis matches. We also include highly detailed commentary style descriptions, which are heavily dependent on both the occurrence as well as the sequence of particular events. We use general deep learning techniques to acquire some initial baseline results on our dataset, without the need for explicit domain-specific assumptions.
[Scoliosis screening using plantar pressure analysis].

UNLABELLED Earlier scoliosis detection is one of the orthopedics and family doctor challenge. Normally, the first observation about a child deformity should be done by the family doctor in order to announce or not the need of special investigations by a specialist. Usually, the so called idiopathic scoliosis is determined by some factor that interfere during the growing period and most of the time a wrong body attitude static and dynamic during daily activities (learning, sleeping, playing, sitting) and/or angular discrepancy or limb length discrepancy. MATERIAL AND METHOD All those factors effects can be seen in a plantar pressure analysis evaluation witch soft give us information about the center of gravity of the body and the pressure on the foot that can be correlate in order to discover any articulation imbalance, even the spine deformity. RESULTS It has been demonstrated through algorithms and case studies that a specific pattern of the plantar pressure analysis image is characteristic for the scoliotic persons.
Neocortical epileptogenesis in vitro: studies with N-methyl-D-aspartate, phencyclidine, sigma and dextromethorphan receptor ligands.

Slices of rat neocortex have been used to study the role of N-methyl-D-aspartate (NMDA) receptors in the induction of epileptiform activity. The NMDA antagonist potency of a range of compounds with putative anticonvulsant activity has been compared with their ability to reduce epileptiform activity in this tissue. Epileptiform activity was induced by the omission of magnesium from the bathing medium. Competitive and noncompetitive phencyclidine-like NMDA antagonists reduced such spontaneous and stimulus-evoked epileptiform bursts and after potentials. Similar epileptiform activity induced by the addition of proconvulsant drugs, e.g. gamma-aminobutyric acidA antagonists, potassium channel blockers or carbachol was reduced by ketamine and/or D-2-amino-5-phosphonovaleric acid. In magnesium-free medium, the frequency of spontaneous bursts and the number of afterpotentials per burst were reduced in parallel. There was a good correlation (r greater than 0.9) between their potencies against NMDA depolarizations and against epileptiform bursts (MK-801 [(+)-5-methyl-10,11- dihydro-5H-dibenzvo[a,d]cyclohepten-5,10-imine] greater than thienylcyclohexylpiperidine phencyclidine greater than 3-(2-carboxypiperazine-4-yl)propyl-1-phosphonic acid greater than cyclazocine greater than D-2-amino-5-phosphonovaleric acid greater than dextrorphan greater than SKF10,047 (N-allylnormetazocine) greater than ketamine greater than dextromethorphan = or greater than pentazocine). Sigma and dextromethorphan receptor ligands (e.g. ditolyguanidine, carbetapentane and phenytoin), whereas inactive as NMDA antagonists, reduced epileptiform activity by decreasing the number of afterpotentials per burst with less effect on the burst frequency. The quisqualate/kainate antagonist, FG9041 (6,7-dinitro-quinoxaline-2,3-dione), only reduced spontaneous bursts at doses which also reduced NMDA. Our results imply a central role for NMDA receptors in epileptogenesis in neocortical slices.
Analysis of ER–mitochondria contacts using correlative fluorescence microscopy and soft X-ray tomography of mammalian cells

ABSTRACT Mitochondrial fission is important for organelle transport, quality control and apoptosis. Changes to the fission process can result in a wide variety of neurological diseases. In mammals, mitochondrial fission is executed by the GTPase dynamin-related protein 1 (Drp1; encoded by DNM1L), which oligomerizes around mitochondria and constricts the organelle. The mitochondrial outer membrane proteins Mff, MiD49 (encoded by MIEF2) and MiD51 (encoded by MIEF1) are involved in mitochondrial fission by recruiting Drp1 from the cytosol to the organelle surface. In addition, endoplasmic reticulum (ER) tubules have been shown to wrap around and constrict mitochondria before a fission event. Up to now, the presence of MiD49 and MiD51 at ER–mitochondrial division foci has not been established. Here, we combine confocal live-cell imaging with correlative cryogenic fluorescence microscopy and soft x-ray tomography to link MiD49 and MiD51 to the involvement of the ER in mitochondrial fission. We gain further insight into this complex process and characterize the 3D structure of ER–mitochondria contact sites. Highlighted Article: Confocal live-cell imaging combined with correlative cryogenic fluorescence microscopy and soft X-ray tomography provide new insights into the complex process of mitochondrial fission in mammalian cells.
Screening of antimicrobial activity of Cistus ladanifer and Arbutus unedo extracts

In this work, the in vitro antimicrobial activity of different crude extracts obtained from Cistus ladanifer L. and Arbutus unedo L. was investigated. The ethanol, methanol and acetone/water extracts of Cistus ladanifer and Arbutus unedo were prepared using different extraction methods and their antimicrobial activities against reference strains, including three Gram-positive, five Gram-negative and three yeasts, and against clinical isolates of Helicobacter pylori and methicillin-resistant Staphylococcus aureus, were investigated. All the extracts inhibited more than one microorganism; moreover all of them presented antimicrobial activity against the Gram-positive bacteria, Klebsiella pneumonia, Candida tropicalis and Helicobacter pylori. It is noteworthy that the most considerable in vitro effect was observed against Helicobacter pylori. These inhibitory effects can be considered relevant to the development of new agents for inclusion in the treatment or prevention of infections by the tested strains.
HIGH-RESOLUTION SIMULATIONS OF THE REIONIZATION OF AN ISOLATED MILKY WAY–M31 GALAXY PAIR

We present the results of a set of numerical simulations aimed at studying reionization at the galactic scale. We use a high-resolution realization of the formation of the Milky Way (MW)–M31 system to simulate the reionization of the Local Group. The reionization calculation was performed with the post-processing radiative transfer code ATON and the underlying cosmological simulation was performed as part of the CLUES project (http://www.clues-project.org). We vary the source models to bracket the range of source properties used in the literature. We investigate the structure and propagation of the galactic ionization fronts by a visual examination of our reionization maps. Within the progenitors, we find that reionization is patchy and proceeds locally inside-out. The process becomes patchier with decreasing source photon output. It is generally dominated by one major H ii region and one to four additional isolated smaller bubbles, which eventually overlap. Higher emissivity results in faster and earlier local reionization. In all models, the reionization of the MW and M31 are similar in duration, i.e., between 203 Myr and 22 Myr depending on the source model, placing their zreion between 8.4 and 13.7. In all models except the most extreme, the MW and M31 progenitors reionize internally, ignoring each other despite being relatively close to each other, even during the epoch of reionization. Only in the case of strong supernova feedback suppressing star formation in halos less massive than 109 M☉, and using our highest emissivity, do we find that the MW is reionized by M31.
Identification of a Candidate Streptococcus pneumoniae Core Genome and Regions of Diversity Correlated with Invasive Pneumococcal Disease

ABSTRACT Streptococcus pneumoniae is a leading cause of community-acquired pneumonia and gram-positive sepsis. While multiple virulence determinants have been identified, the combination of features that determines the propensity of an isolate to cause invasive pneumococcal disease (IPD) remains unknown. In this study, we determined the genetic composition of 42 invasive and 30 noninvasive clinical isolates of serotypes 6A, 6B, and 14 by comparative genomic hybridization. Comparison of the present/absent gene matrix (i.e., comparative genomic analysis [CGA]) identified a candidate core genome consisting of 1,553 genes (73% of the TIGR4 genome), 154 genes whose presence correlated with the ability to cause IPD, and 176 genes whose presence correlated with the noninvasive phenotype. Genes identified by CGA were cross-referenced with the published signature-tagged mutagenesis studies, which served to identify core and IPD-correlated genes required for in vivo passage. Among these, two pathogenicity islands, region of diversity 8a (RD8a), which encodes a neuraminidase and V-type sodium synthase, and RD10, which encodes PsrP, a protein homologous to the platelet adhesin GspB in Streptococcus gordonii, were identified. Mice infected with a PsrP mutant were delayed in the development of bacteremia and demonstrated reduced mortality versus wild-type-infected controls. Finally, the presence of seven RDs was determined to correlate with the noninvasive phenotype, a finding that suggests some RDs may contribute to asymptomatic colonization. In conclusion, RDs are unequally distributed between invasive and noninvasive isolates, RD8a and RD10 are correlated with the propensity of an isolate to cause IPD, and PsrP is required for full virulence in mice.
Caring for others: Internet video-conferencing group intervention for family caregivers of older adults with neurodegenerative disease.

PURPOSE The aim of this pilot feasibility study was to evaluate the effects of an innovative, Internet-based psychosocial intervention for family caregivers of older adults with neurodegenerative disease. DESIGN AND METHODS After receiving signed informed consent from each participant, we randomly assigned 66 caregivers to an Internet-based intervention or to a no-intervention control group. The intervention group received computers and training in order to access a password-protected Web site with links to information, e-mail, and threaded discussion. Unique to the Web site was a video-conferencing link that supported caregivers' participation in a 10-session, manual-guided psychosocial support group, followed by 12 additional online sessions facilitated by a group member. Participants completed health-status and stress-response measures at baseline and 6-month follow-up. RESULTS Content analysis of archived video sessions showed (a) reliable adherence to the manual-guided support-group intervention and (b) online group discussion themes similar to those in face-to-face caregiver support groups. Analyses of stress-response outcome data showed significant between-group differences, with the intervention group experiencing a decline in stress compared with an escalation in stress for the control group. IMPLICATIONS Despite the limitations of this pilot study in terms of limited sample size and 54% dropout of control participants at 6-month follow-up, the results provide preliminary supportive evidence for a technology-based psychosocial intervention for family caregivers of individuals with neurodegenerative disease.
[Alcohol and other psychoactive substances addiction risk assessment among chosen high school students test group].

UNLABELLED Use of nicotine, alcohol and other psychoactive substances plays an important role in youth death rate and incidence proportion. The probability of accidents, risky sexual behaviors or interpersonal aggression rises when young people are under the influence of alcohol or other drugs. In all the developed countries alcohol and other psychoactive substances are the main risk factors leading to youth death caused by traffic accidents, murders and suicides. That is the reason why the popularization of a simple and effective screening tool that would allow choosing the high risk youth group and implementing early intervention program is so important to conduct in Poland. AIM Alcohol and other psychoactive substances addiction risk assessment within the chosen test group of high school youth attending different types of schools in a medium size city. MATERIAL AND METHODOLOGY Study was conducted in February 2014 in three high schools - public high school, catholic high school and technical high school, located in Stalowa Wola reaching 119 students from 3rd grade (18-19 years old). Study utilized CRAFFT test (Alcohol and Other Drug Screening Test). RESULTS Within the past 12 months previous to the screening 92.4% of tested students drunk alcohol, 26.1% smoked marihuana and 10.9% used other psychoactive substances. One fourth of students admitted to driving or riding the car with the driver who was under the influence of alcohol or other drug. One half of the students ad. mitted drinking alcohol or using drugs to relax, improve the mood or to fit in. One in five students was confronted by friends or family members and asked to limit use of alcohol or drugs. CONCLUSION Based on CRAFFT test results over a half of students (53.6%) may be diagnosed with significant psychoactive substances addiction risk and should be promptly subjected to preventive actions.
Pulmonary thromboembolism in American Indians and Alaskan Natives.

BACKGROUND The rate of diagnosis of deep venous thrombosis and/or pulmonary embolism (collectively, venous thromboembolism: VTE) among patients discharged from Indian Health Service hospital care from 1980 through 1996 was considerably lower than rates reported in African Americans or whites. Expansion of the national census in 1990 to include American Indians and Alaskan Natives permits a more in-depth examination of this issue. METHODS Combined data from the National Hospital Discharge Survey (nonfederal hospitals) and the Indian Health Service (federal hospitals) from 1996 through 2001 were used to evaluate the rate of diagnosis of VTE in American Indians and Alaskan Natives. RESULTS The diagnosis of VTE in American Indians and Alaskan Natives, based on combined data from the National Hospital Discharge Survey and the Indian Health Service was 71 per 100,000 per year compared with 155 per 100,000 per year in African Americans (P<.001) and 131 per 100,000 per year in whites (P<.001). The rate ratio comparing the rate of diagnosis of VTE in American Indians and Alaskan Natives with African Americans was 0.46 (95% confidence interval, 0.45-0.47) and comparing American Indians and Alaskan Natives with whites it was 0.54 (95% confidence interval, 0.53-0.55). CONCLUSIONS The observed relatively low incidence of VTE in American Indians and Alaskan Natives would seem to be due to as yet undetermined genetic factors. The possibility that American Indians and Alaskan Natives have different lifestyles that affect the rate of diagnosis of VTE cannot be excluded.
Cathepsin L in metastatic bone disease: therapeutic implications

Abstract Cathepsin L is a lysosomal cysteine proteinase primarily devoted to the metabolic turnover of intracellular proteins. However, accumulating evidence suggests that this endopeptidase might also be implicated in the regulation of other important biological functions, including bone resorption in normal and pathological conditions. These findings support the concept that cathepsin L, in concert with other proteolytic enzymes involved in bone remodeling processes, could contribute to facilitate bone metastasis formation. In support of this hypothesis, recent studies indicate that cathepsin L can foster this process by triggering multiple mechanisms which, in part, differ from those of the major cysteine proteinase of osteoclasts, namely cathepsin K. Therefore, cathepsin L can be regarded as an additional target in the treatment of patients with metastatic bone disease. This review discusses the clinical and therapeutic implications related to these findings.
Stability of the sense of coherence in adolescence

UNLABELLED The aim of this prospective study was to explore the stability of sense of coherence (SOC) in adolescents from the age of 15 to 18 years. METHODS A prospective population-based follow-up study of 1294 first-born children was started in 1986. When the children were 15 (N = 846) and 18 (N = 792) years old, SOC was measured using questionnaires filled out at home. RESULTS The mean change in SOC scores (0.10, SD 10.2; in percentages 1.98%, SD 18.4) in the whole sample between the ages of 15 and 18 years was negligible and non-significant (p = .788). At the individual level, some changes were seen in the scores. The SOC scores of boys at the ages of 15 and 18 years were significantly higher than those of girls (mean 65.4 vs. 60.8 and 65.4 vs. 61.7, respectively). The SOC scores of adolescents living with both parents were higher than those with one parent or other guardian (mean 64.5 vs. 59.9), and the difference was significant in both age groups (p < .001). CONCLUSION Contrary to assumptions made in Antonovsky's theory, we found no significant change in SOC between the ages of 15 to 18 years, and coherence stability did not depend on the initial SOC. Some fluctuation in SOC scores was seen at the individual level. For planning of interventions, it is important to know that SOC seems to be reasonably stabilized before the age of 15 years.
Service providers’ perspectives and residents’ experiences with the implementation of “Housing First” program in the city of London, Ontario, Canada

ABSTRACT Housing First (HF) is now an internationally promoted community housing model for long-term homeless individuals who have mental health difficulties including substance abuse issues. This study aimed to understand the perspectives and experiences of service providers and residents associated with the London CAReS program, an HF program currently operating in the city of London, Ontario, Canada. London CAReS was designed to transition homeless individuals off the street and into housing with consumer-driven supports. This empirical analysis is a response to the need to capture the perspectives and experiences of service providers and residents associated with HF projects, particularly as they reflect areas of policy intervention. Analysis of semi-structured qualitative interviews with five service providers suggests that London CAReS is a more effective approach to housing homeless individuals than previous Treatment First services. Service providers noted that key strengths of the project are access to stable housing, availability of ongoing support, community integration, and the opportunity to build sustained relationships with participants. Similarly, 65 residents interviewed for this study expressed a high level of satisfaction with the program. In contrast to the system that had “previously failed them,” residents noted that the CAReS program provided improvement in their health status, access to independent apartment, continuous support from London CAReS workers, choices in services, and the opportunity to build trusting relationships with support staff. Despite the positive experiences of service providers and residents, the interviews revealed several critical implementation challenges. The study points to relevant areas of policy intervention.
Sensitivity and Specificity of Urinary Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 for the Diagnosis of Renal Cell Carcinoma

Background/Aims: Neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) are urinary biomarkers of diagnostic relevance in a wide variety of acute and chronic kidney diseases. Their diagnostic sensitivity and specificity for kidney cancer are largely unknown and therefore the subject of this investigation. Methods: A prospective cohort study was performed to evaluate urine biomarkers for clear-cell and papillary subtypes of renal cancer (67 patients undergoing nephrectomy) and 55 control patients undergoing non-kidney surgery. Urinary KIM-1 and NGAL concentrations were determined by sensitive and specific ELISAs. Results: In renal cancer patients, median NGAL excretion was 0.52 (1st to 3rd quartiles: 0.28–0.82) ng/mg urinary creatinine (UCr) before nephrectomy compared to 0.15 (0.04–0.31) ng/mg UCr in controls (p < 0.001), and there was a modest decrease of 30% after nephrectomy (p < 0.008). NGAL was not correlated to tumor size (r = 0.19, p = 0.27) or stage. Before nephrectomy, KIM-1 excretion was 0.68 (0.40–1.12) ng/mg UCr compared to 0.03 (0.01–0.06) in controls (p < 0.001). There was a linear correlation between KIM-1 excretion before nephrectomy and tumor size (Spearman’s r = 0.66, p < 0.001), tumor stage, and a 50% decrease in median KIM-1 concentration 1 month following tumor excision (p < 0.01). Biomarker concentration ranges for renal cancer patients and controls overlapped substantially for NGAL but not KIM-1. Conclusion: NGAL is not a sensitive or specific urinary biomarker of kidney cancer. Although KIM-1 had diagnostic sensitivity for kidney cancer, it is well known to reflect many types of kidney injuries, thus limiting its specificity as a diagnostic biomarker for renal cancer.
Targeting delivery of simvastatin using ICAM-1 antibody-conjugated nanostructured lipid carriers for acute lung injury therapy

Abstract Acute lung injury (ALI) is a critical illness without effective therapeutic modalities currently. Recent studies indicated potential efficacy of statins for ALI, while high-dose statins was suggested to be significant for attenuating inflammation in vivo. Therefore, a lung-targeted drug delivery system (DDS) delivering simvastatin (SV) for ALI therapy was developed, attempting to improve the disease with a decreased dose and minimize potential adverse effects. SV-loaded nanostructured lipid carriers (SV/NLCs) with different size were prepared primarily. With particle size increasing from 143.7 nm to 337.8 nm, SV/NLCs showed increasing drug-encapsulated efficiency from 66.70% to 91.04%. Although larger SV/NLCs exhibited slower in vitro cellular uptake by human vascular endothelial cell line EAhy926 at initial stage, while in vivo distribution demonstrated higher pulmonary accumulation of the larger ones. Thus, the largest size SV/NLCs (337.8 nm) were conjugated with intercellular adhesion molecule 1 (ICAM-1) antibody (anti-ICAM/SV/NLCs) for lung-targeted study. The anti-ICAM/SV/NLCs exhibited ideal lung-targeted characteristic in lipopolysaccharide-induced ALI mice. In vivo i.v. administration of anti-ICAM/SV/NLCs attenuated TNF-α, IL-6 and inflammatory cells infiltration more effectively than free SV or non-targeted SV/NLCs after 48-h administration. Significant histological improvements by anti-ICAM/SV/NLCs were further revealed by H&E stain. Therefore, ICAM-1 antibody-conjugated NLCs may represent a potential lung-targeted DDS contributing to ALI therapy by statins.
The Psychosocial Impact of Cancer on the Elderly: A Comparison with Younger Patients

This report examines the psychosocial impact of cancer in 240 men according to age using a recently developed cancer‐specific survey instrument. Overall, younger patients experienced more frequent or severe psychosocial and treatment‐related problems than the older patients, especially in relation to work and chemotherapy. In addition, younger patients experienced more difficulty dealing with the health care setting. The authors conclude that the elderly cancer patient experiences less psychosocial disruption from cancer than do younger individuals. J Am Geriatr Soc 33:429, 1985