Miracle-dz/UniFAR-FTUs huggingface dataset:
Expression of CD163 (Hemoglobin Scavenger Receptor) in Normal Tissues, Lymphomas, Carcinomas, and Sarcomas Is Largely Restricted to the Monocyte/Macrophage Lineage

CD163, a hemoglobin scavenger receptor, is expressed in monocytes and macrophages. We tested the expression of the CD163 protein in 1,105 human malignancies and normal tissues using tissue microarrays and conventional paraffin-embedded tissue sections. Besides staining nonneoplastic monocytes and histiocytes (tissue macrophages), membranous/cytoplasmic staining for CD163 was primarily limited to neoplasms with monocytic/histiocytic differentiation. CD163 reactivity was not observed in normal tissues, lymphomas, carcinomas, and in a majority of mesenchymal neoplasms, including follicular dendritic cell tumors (0 of 4), although it stained admixed histiocytes. Staining for CD163 was seen in Rosai-Dorfman disease (5 of 6), histiocytic sarcoma (3 of 4), littoral cell angioma (6 of 6), and Langerhans cell histiocytosis (3 of 5). A subset of atypical fibrous histiocytomas (9 of 16), benign fibrous histiocytomas (6 of 9), and atypical fibroxanthomas (1 of 3) also showed CD163 staining. Our studies also confirm earlier work showing that CD163 is expressed in acute myeloid leukemia with monocytic differentiation (AML, FAB subtype M5) (2 of 6), as well as a majority of giant cell tenosynovial tumors (7 of 8). Its limited range of expression and tissue specificity indicate that CD163 may have significant diagnostic utility in separating specific tumors with monocytic and histiocytic derivation from other entities in their differential diagnosis.
The determinants of corporate hedging for U.S. and U.K. non-financial firms

Empirical studies show that the use of derivative instruments has been increasing during the last decade, making it an important part of the firm’s overall risk management profile. Financial theory suggests that risk management decisions only matter when markets are imperfect. The standard view is that firms will benefit from hedging, because hedging reduces the variability of the costs of financial distress, agency costs, and the expected tax liabilities. This thesis attempts to provide evidence on these hypotheses. This study investigates the determinants of corporate hedging by using a comprehensive dataset of US and UK non-financial firms. The two countries are of particular research interest since they have almost similar legal system for the conduct of business and their market-based financial systems and equity markets are well developed with good investor protection. The study focuses on the decision of whether or not non-financial firms from both countries benefit from corporate hedging during the period 2002-2011. The study is motivated by the idea of whether or not the hedging policies of non-financial firms depend on the financial characteristics of those firms and the strength of their corporate governance. Indeed, our empirical results show that corporate hedging decision is closely associated with firms’ financial characteristics and the strength of their corporate governance. In particular, firms are more like to engage in hedging if they have high expected tax liabilities, high expected cost of financial distress, and high expected agency costs. Firms choose to hedge to reduce the variability of cash flows in order to protect growth opportunities. More interestingly, US firms provide stronger evidence in support of for corporate hedging when the overinvestment problem exists, while UK firms provide stronger evidence for the underinvestment problem. Hedgers tended to be high-rated firms and larger firms which have a cost advantage in hedging due to economies of scale. This finding provides an explanation of why the small firms, which have more volatile cash flows, higher costs of bankruptcy, more growth opportunities, tend not to engage in hedging. We believe that this is very informative as it suggests the costs of hedging and market price dynamics alter the optimal hedging policies of those firms. Hedging is more costly for small firms; so they have different hedging policies and respond differently to hedging. We also find that the board structure influence hedging decisions and a large board tend to be negatively associated with corporate hedging. The tendency to hedge increases as the number of non-executives grows. In addition, firms with strong corporate governance tend to hedge to reduce the variability of cash flows and the costs of financial distress. These results have theoretical and practical implications.
Longitudinal course of pharmacotherapy in obsessive–compulsive disorder

BackgroundAlthough data fully support the use of serotonin reuptake inhibitors (SRIs) in the treatment of obsessive–compulsive disorder (OCD), investigations on pharmacotherapy discontinuation during the course of OCD are lacking. This 5-year prospective study sought to better understand the long-term course of SRI utilization among individuals with OCD. MethodsA total of 252 adult outpatients with Diagnostic and Statistical Manual of Mental Disorders, 4th ed. OCD, treated with medication in the community, were examined for discontinuation and resumption of SRIs. Data on weekly OCD symptoms, medications, and dosage changes were obtained annually using the Longitudinal Interval Follow-up Evaluation. ResultsDuring the 5-year follow-up period, 151 patients had at least one trial of an SRI for 12 weeks or more. A total of 110 patients (43.7%) discontinued their medication (i.e. ceased taking medication for ≥4 weeks) at least once during the follow-up period. In patients symptomatic at the time of discontinuation, the cumulative incidence of worsening of OCD after SRI discontinuation was 9.8%, whereas in patients in partial or full remission at the time of discontinuation, the corresponding cumulative incidence was 33.3%. Among patients with worsening of OCD upon SRI discontinuation, the median time to worsening was 39 weeks. ConclusionThis first longitudinal study on the use of SRIs in OCD found that patients who had achieved partial or full remission on SRIs were less likely to discontinue medication, and the cumulative incidence of worsening of OCD after discontinuation was negatively associated with OCD severity at the time of SRI discontinuation.
NUCLEAR HYPERSEGMENTATION IN MYELOMA CELLS

Kontoghiorghes. G.J. (1986) Orally active a-ketohydroxypyridme iron chelators: studies in mice. Molecular Pharmacology. 30, 670673. Kontoghiorghes, G.J., Sheppard. L. HoRbrand, A.V. Charalambus. J., Tikerpae. J. & Pippard. M.J. (1987) Iron chelation studies using desferrioxamine and the potential oral chelator 1.2dimethyl-3hydroxypyrid-4-one, in normal and iron overloaded rats. journal of Clinical Pathology. 40, 404-408. tau, E.H. Cemy, E.A. Wright, B.J. & Rahman, Y.E. (1983) Improvement of iron removal from the reticuloendothelial system by liposome encapsulation of N.N’-bis( 2-hydroxybenzyl)ethylenediamine-N.N’diacetic acid (HBED). journal of Laboratory and Clinical Medicine. 101, 806-816. Rahrnan. Y.E. , Cerny. E.A. , tau, E.H. & Cames, B.A. (1983) Enhanced iron removal from liver parenchymal cells in experimental iron overload: liposome encapsulation of HBED and phenobarbital administration. Blood. 62, 209-2 13. Venkatararn. S. & Rahman. Y.E. (1990) Studies of an oral iron chelator: 1.2-dimethyI-3-hydroxypyrid-4-one. 1. Iron excretion in rats: development of a new rapid microware method for iron analysis in faeces. British journal of Haematology. 75, 274-277.
Which UGC features drive web purchase intent? A spike-and-slab Bayesian Variable Selection Approach

– The purpose of this paper is to identify user-generated content (UGC) features that determine web purchase decision making. , – The authors embed a spike-and-slab Bayesian variable selection mechanism into a logistic regression model to identify the UGC features that are critical to web purchase intent. This enables us to make a highly reliable analysis of survey data. , – The results indicate that the web purchase decision is driven by the relevance, up-to-dateness and credibility of the UGC information content. , – The results show that the characteristics of UGC are seen as positive and the medium enables consumers to sort information and concentrate on aspects of the message that are similar to traditional word-of-mouth (WOM). One important implication is the relative importance of credibility which has been previously hypothesized to be lower in the electronic word-of-mouth (e-WOM) context. The results show that consumers consider credibility important as the improved technology provides more possibilities to find out about that factor. A limitation is that the data are not fully representative of the general population but our Bayesian method gives us high analytical quality. , – The study shows that UGC impacts consumer online purchase intentions. Marketers should understand the wide range of media that provide UGC and they should concentrate on the relevance, up-to-dateness and credibility of product information that they provide. , – The analytical quality of the spike- and- slab Bayesian method suggests a new way of understanding the impact of aspects of UGC on consumers.
Impact of a Three Amino Acid Deletion in the CH2 Domain of Murine IgG1 on Fc-Associated Effector Functions1

Four murine IgG subclasses display markedly different Fc-associated effector functions because of their differential binding to three activating IgG Fc receptors (FcγRI, FcγRIII, and FcγRIV) and C1q. Previous analysis of IgG subclass switch variants of 34-3C anti-RBC monoclonal autoantibodies revealed that the IgG1 subclass, which binds only to FcγRIII and fails to activate complement, displayed the poorest pathogenic potential. This could be related to the presence of a three amino acid deletion at positions 233–235 in the CH2 domain uniquely found in this subclass. To address this question, IgG1 insertion and IgG2b deletion mutants at positions 233–235 of 34-3C anti-RBC Abs were generated, and their ability to initiate effector functions and their pathogenicity were compared with those of the respective wild-type Abs. The insertion of amino acid residues at positions 233–235 enabled the IgG1 subclass to bind FcγRIV but did not improve the binding to C1q. Accordingly, its pathogenicity was enhanced but still inferior to that of IgG2b. In contrast, the IgG2b deletion mutant lost its ability to bind to FcγRIV and activate complement. Consequently, its pathogenicity was markedly diminished to a level comparable to that of IgG1. Our results demonstrated that the initiation of FcγR- and complement-mediated effector functions of IgG2b was profoundly affected by the three amino acid deletion at positions 233–235, but that this natural three amino acid deletion could only partially explain the poor binding of IgG1 to FcγRIV and C1q. This indicates the lack in the IgG1 subclass of as yet unknown motifs promoting efficient interaction with FcγRIV and C1q.
PROMIS Physical Function Correlation With NDI and mJOA in the Surgical Cervical Myelopathy Patient Population

Study Design. Retrospective review. Objective. To determine the correlation of Patient-Reported Outcomes Measurement Information System (PROMIS) physical function with Neck Disability Index (NDI) and Modified Japanese Orthopedic Association (mJOA) scores in the surgical cervical myelopathy patient population. Summary of Background Data. Outcome measures such as NDI and mJOA are essential for analyzing treatments for cervical myelopathy. Administrative burdens impose limits on completion of these measures. The PROMIS group developed an outcome measure to improve reporting of patient symptoms and function and to reduce administrative burden. Despite early success, NDI and mJOA have not been compared with PROMIS in patients with cervical myelopathy. This study determines the correlation of NDI and mJOA with PROMIS in surgical patients with cervical myelopathy. Methods. A total of 60 patients with cervical myelopathy undergoing surgery were included. PROMIS, NDI, and mJOA were collected preoperatively, and in the first 6 months postoperatively. Correlations between NDI, mJOA, and PROMIS were quantified using Pearson correlation coefficients. Students t tests were used to test significance. Results. All 60 (100%) of patients completed preoperative questionnaires. Fifty-five (92%) of patients completed initial follow-up questionnaires within the first 6 months. PROMIS physical function and NDI demonstrated a strong negative correlation at baseline and in initial follow-up (R = −0.69, −0.76). PROMIS and mJOA demonstrated a strong positive correlation at baseline and in initial follow-up (R = 0.61, 0.72). Conclusion. PROMIS physical function has a strong negative correlation with NDI and a strong positive correlation with mJOA at baseline and in the early postoperative course in patients undergoing surgery for cervical myelopathy. Surgeons may factor these outcomes into the delivery and interpretation of patient-reported outcome measures in this population. Use of PROMIS may improve completion of outcome measures in the office and reduce administrative burden while still providing reliable outcomes data. Level of Evidence: 3
Co-Determination as a Path to Goal Commitment: Managing Danish Upper Secondary Schools

Abstract Performance management systems that include goal setting have become a widespread instrument in public management, intended to ensure that the entire organization is working to meet the same goals. One key question, however, is how public managers can ensure their employees’ commitment to the goals that management has chosen to prioritize. This article examines the importance of “co-determination” for the relationship between managers’ goal prioritization and the goal commitment of the employees in upper secondary schools in Denmark. Co-determination has the potential to create a common direction and committed employees, thereby rendering it a valuable tool for public managers in goal setting processes. Analysis of ten qualitative interviews with teachers and principals provides rich insight into the concept of co-determination in the context of Danish education, and a quantitative analysis of two parallel questionnaires with 73 principals and 1353 teachers reveals how co-determination has a positive impact on the association between a school principal’s prioritization of the goal of achieving a high completion rate and the teachers’ commitment to the goal.
Sedimentary geology.

Above: key component of understanding impacts to arid regions. Our research focuses on the physical mechanisms that shape ecological responses, providing a foundation for understanding the effects of local and regional extreme events in a changing climate. of galaxies in low density environments Measuring the masses of black holes using the variability of the central region in Seyfert galaxies and quasars. spectral and brigtness measurements
Integrated farming System: Profitable farming to small farmers

Indian Scenario 80% of Small and Marginal farmers out of 115 operational land holding growing monocarp or commercial crop having less profitable due many constraints. From field study conducted on performance of integrated farming system over farmers practice system for one ha. Area at Agricultural Research Station, Hagari, Ballari, Karnataka for four successive years of 2010-11 to 2013-14 in deep black soils to explore the productivity and profitability under irrigated condition. Among the system evaluated integrated farming system has recorded higher average net returns (Rs. 64380) and benefit cost ratio (10.35) over the conventional method. Higher Profitability and productivity with lesser cost of cultivation of integrated farming system when compared to farmers practice.
The Determinant of Banking Efficiency in Indonesia (DEA Approach)

This research is aimed to analyze efficiency performance in banking industries in Indonesia within 2012-2014 period. Data Envelopment Analysis method was used to find determinant in Tobit regression model. Purposive sampling was used to determine samples with the number of companies up to 89 banks consist of 5 different groups. Those are 26 state and local government own enterprises, 6 foreign banks, 11 mixed banks, 19 BUSN Devisa, 27 BUSN non Devisa. Based on analysis result, obtained that the foreign banks has the efficiency the highest compared to a group of banks BUMN/BUMD ( the government banks), BUSN non-foreign exchange , BUSN foreign exchange , and a group of banks a mixture. Efficiency in banking influenced by return on assets (ROA). The higher roa will be able to improve the efficiency banks in indonesia . Keywords: DEA, Tobit, ROA, CAR, NPL
Children with severe early childhood caries: pilot study examining mutans streptococci genotypic strains after full-mouth caries restorative therapy.

PURPOSE Genotypic strains of mutans streptococci (MS) may vary in important virulence properties and be differentially affected by specific components of full-mouth caries restorative therapy. The purpose of this pilot study was to identify mutans streptococci strains that predominate following caries restorative therapy. METHODS Plaque from 7 children with severe early childhood caries was collected before and following therapy. MS isolates (N=828) were subjected to polymerase chain reaction (PCR) and arbitrarily primed-PCR (AP-PCR) for assignment within MS strains. Determining the longitudinal changes in MS strain distribution over time within each patient required the isolation of larger numbers of isolates per patient, but from fewer patients. RESULTS Up to 39 genotypic strains of Streptococcus mutans and Streptococcus sobrinus, and 7 genotypic strains of non-MS streptococci were identified by AP-PCR and 16S ribosomal rRNA gene sequencing. The number of MS strains isolated from each patient were 3 to 7 prior to treatment, diminishing to 1 to 2 dominant MS strains in most patients 6 months following therapy. CONCLUSIONS Caries restorative therapy resulted in shifts of specific mutans streptococcus and non-mutans streptococcus strains. The implications are that caries restorative therapy affects the distribution of MS strains, and that well-accepted practices for caries prevention should be more closely examined for efficacy.
A technology-fashion collaborative product: Its impact on consumer attitudes and purchase intention

Abstract This study seeks to investigate consumers’ willingness to adopt a collaborative product by answering three research questions: (1) how do two types of innovativeness (i.e. technology innovativeness and fashion innovativeness) influence perceived product innovativeness, (2) how do the two types of consumer innovativeness affect utilitarian and hedonic attitudes toward a technology-fashion collaborative product, and (3) how do these effects cooperate to influence consumers to purchase the collaborative product? Data were collected from 339 respondents and structural equation modeling was employed to test the proposed model. Of most interest is that consumers’ utilitarian attitudes toward the product do not influence purchase intentions, whereas consumers’ hedonic attitudes lead to purchase intention of the technology-fashion collaborative product. This study’s findings provide the bases for making suggestions to marketers who are planning to work with another industry regarding whether and how they can provide synergy between two product types.
PREDICTION OF CANCER MORTALITY BY EVALUATION OF ASBESTOS FIBERS CONCENTRATIONS IN AN ASBESTOS-CEMENT PRODUCTS FACTORY

Although the asbestos application is band in most developed countries but it is still used in many developing countries, escalating the mortality rate due to cancer among the workers exposed to asbestos fibers. In the present work, occupational exposure to airborne asbestos fibers in production line of an asbestos-cement products manufacturing factory were assessed, using OSHA method ID-160. For this purpose, 106 personal air samples were collected from breathing zones of workers in various processes of the factory. Cancer-related mortalities were also predicted by extrapolation of OSHA risk assessment data to the data obtained from the factory in question. The results revealed that physically disturbing processes such as mills, drilling and cutting are the most deadly processes. It was also shown that mills have the highest mortality rate due to asbestos fibers exposure, expecting 1198 deaths per 100,000 workers after one year exposure and 14665 deaths per 100,000 workers after 20 years occupational exposure. Relative risk (RR) of lung cancer after 1, 20 and 45 years working in the factory in question versus public community of Iran would be 11.6, 206.5 and 324, respectively. Cancer-related mortality predicted for dry cutting process was more than wet cutting process(RR=3.6). Finally it was recommended that job rotation and isolation of high risk operations could lead to lower cancer-related mortality due to occupational exposure to asbestos airborne fibers.
Regionally Specific Effects of BDNF on Oligodendrocytes

To define the effects of neurotrophins on oligodendrocytes, we monitored NGF, BDNF and NT-3 actions on basal forebrain (BF) and cortical populations. NGF, BDNF and NT-3 applied to BF oligodendrocytes elicited increases in expression of myelin basic protein (MBP) and enhanced the numbers of MBP+ cells, without affecting total cell numbers. In the cortex, however, while NGF and NT-3 influenced MBP expression, BDNF was without effect. To explore this apparent regional difference in BDNF action, we compared expression of the neurotrophin receptors trkA, trkB and trkC. While BF cells expressed all three trks, cortical cells did not express the full-length BDNF receptor, trkB. Interestingly, in no case was any receptor expressed by all oligodendrocytes, indicating that oligodendrocytes may be heterogeneous within a brain region. The data suggest that BF oligodendrocytes are influenced by BDNF to express MBP and are distinct in this ability from cortical cells.
Ondansetron plus metopimazine compared with ondansetron alone in patients receiving moderately emetogenic chemotherapy.

BACKGROUND AND METHODS The serotonin (5-hydroxytryptamine3) antagonists have improved the treatment of acute chemotherapy-induced nausea and vomiting, but their ability to prevent delayed nausea and vomiting seems less pronounced. The results of a preliminary open trial suggested that the addition of a selective dopamine D2 antagonist could improve the antiemetic efficacy of the serotonin antagonists. In a randomized, double-blind, crossover trial, we compared oral treatment with ondansetron (8 mg twice a day) and the dopamine D2 antagonist metopimazine (30 mg four times a day) with treatment with ondansetron alone for three days in 30 patients who had vomited during the previous cycle of chemotherapy. All the patients received moderately emetogenic chemotherapy. RESULTS Combination treatment with ondansetron and metopimazine significantly reduced the incidence of acute (P = 0.006) and delayed (P = 0.02) nausea and acute (P = 0.02) and delayed (P = 0.006) vomiting, as compared with treatment with ondansetron alone. Patients had significantly fewer days of nausea (P = 0.03) and vomiting (P = 0.003) if they received combination therapy. Sixty-seven percent of the patients preferred ondansetron and metopimazine, and 33 percent favored ondansetron alone (P = 0.10). Adverse reactions were mild with both regimens. With the exception of constipation, which was reported more frequently with combination therapy (P = 0.03), there were no significant differences in adverse reactions. CONCLUSIONS Ondansetron plus metopimazine is a highly effective and safe antiemetic regimen that is markedly superior to treatment with ondansetron alone in patients receiving moderately emetogenic chemotherapy.