Miracle-dz/UniFAR-FTUs huggingface dataset:
Do Physical Therapy Interventions Improve Urinary Incontinence and Quality of
Life in patient with Multiple Sclerosis: A systematic Literature Review

Background: Multiple sclerosis (MS) presents with many symptoms, including urinary incontinence (UI) that physical therapy can play very important role, which is widely prevent, but the physical therapy management for UI in MS population lacks consensus. We analyzed the current evidence for effectiveness of physical therapy to decrease UI and improve quality of life (QOL) in population with MS. Purpose: To systematically review the literature and present the best available evidence for the efficacy and effectiveness of physical therapy intervention in treating the urinary incontinence for MS population and improve QOL. Data Source: Pub Med, Cochrane library, BMJ Group, BioMed Central, Wiley online library, Cumulative Index to Nursing and Allied Health Literature, and PEDro. Study Selection: 5 randomized, control trials (RCTs) and one clinical trial published in English from 2006- May 2019. Data Extraction: Any study concentrated on surgical or pharmaceutical treatment interventions, focused on bowel incontinence or were not within the physical therapy scope of practice. Data Synthesis: The study focuses on physical therapy intervention for MS patients with UI and randomized control study. Limitation of the Study: The reviewed study is limited to 6 randomized control trials. Conclusion: There is significant evidence that physical therapy interventions in MS patients with urinary incontinence are very effective and had significant change in reducing UI and increasing QOL.
RGC 32 deficiency protects against high-fat diet-induced obesity and insulin resistance in mice

Obesity is an important independent risk factor for type 2 diabetes, cardiovascular diseases and many other chronic diseases. Adipose tissue inflammation is a critical link between obesity and insulin resistance and type 2 diabetes and a contributor to disease susceptibility and progression. The objective of this study was to determine the role of response gene to complement 32 (RGC32) in the development of obesity and insulin resistance. WTand RGC32 knockout (Rgc32 (Rgcc)) mice were fed normal chow or high-fat diet (HFD) for 12 weeks. Metabolic, biochemical, and histologic analyses were performed. 3T3-L1 preadipocytes were used to study the role of RGC32 in adipocytes in vitro. Rgc32 mice fed with HFD exhibited a lean phenotype with reduced epididymal fat weight compared with WT controls. Blood biochemical analysis and insulin tolerance test showed that RGC32 deficiency improved HFD-induced dyslipidemia and insulin resistance. Although it had no effect on adipocyte differentiation, RGC32 deficiency ameliorated adipose tissue and systemic inflammation. Moreover, Rgc32 induced browning of adipose tissues and increased energy expenditure. Our data indicated that RGC32 plays an important role in diet-induced obesity and insulin resistance, and thus it may serve as a potential novel drug target for developing therapeutics to treat obesity and metabolic disorders.
Bayesian inference of earthquake rupture models using polynomial chaos expansion

Abstract. In this paper, we employed polynomial chaos (PC) expansions to understand earthquake rupture model responses to random fault plane properties. A sensitivity analysis based on our PC surrogate model suggests that the hypocenter location plays a dominant role in peak ground velocity (PGV) responses, while elliptical patch properties only show secondary impact. In addition, the PC surrogate model is utilized for Bayesian inference of the most likely underlying fault plane configuration in light of a set of PGV observations from a ground-motion prediction equation (GMPE). A restricted sampling approach is also developed to incorporate additional physical constraints on the fault plane configuration and to increase the sampling efficiency.
Antibiotic Resistance Profiles of Haemophilus influenzae Isolates from Children in 2016: A Multicenter Study in China

Background and Objective Haemophilus influenzae (HI) is a common cause of community-acquired pneumonia in children. In many countries, HI strains are increasingly resistant to ampicillin and other commonly prescribed antibiotics, posing a challenge for effective clinical treatment. This study was undertaken to determine the antibiotic resistance profiles of HI isolates from Chinese children and to provide guidelines for clinical treatment. Methods Our Infectious Disease Surveillance of Pediatrics (ISPED) collaboration group includes six children's hospitals in different regions of China. The same protocols and guidelines were used by all collaborators for the culture and identification of HI. The Kirby–Bauer method was used to test antibiotic susceptibility, and a cefinase disc was used to detect β-lactamase activity. Results We isolated 2073 HI strains in 2016: 83.9% from the respiratory tract, 11.1% from vaginal secretions, and 0.5% from blood. Patients with respiratory isolates were significantly younger than nonrespiratory patients (P < 0.001). Of all 2073 strains, 50.3% were positive for β-lactamase and 58.1% were resistant to ampicillin; 9.3% were β-lactamase-negative and ampicillin-resistant. The resistance rates of the HI isolates to trimethoprim-sulfamethoxazole, azithromycin, cefuroxime, ampicillin-sulbactam, cefotaxime, and meropenem were 71.1%, 32.0%, 31.2%, 17.6%, 5.9%, and 0.2%, respectively. Conclusions More than half of the HI strains isolated from Chinese children were resistant to ampicillin, primarily due to the production of β-lactamase. Cefotaxime and other third-generation cephalosporins could be the first choice for the treatment of ampicillin-resistant HI infections.
Production Performance in Russian Regions : Farm Level Analysis

The Russian agricultural sector has experienced many problems since the beginning of the 1990s that resulted in a fall in farm output. Employing a production function approach and, unlike other studies, farm-level data on more than 20,000 Russian large-scale farms for the period 1995-2000, this study analyzes the impact of both production (land, labour, capital, materials) and financial (debts and budget transfers) determinants on the productivity. Interregional differences such as weather conditions and farm-specific features such as geographical location, management and soil quality are taken into account employing the fixed-effect estimation. The findings show that Russian farms operate under liquidity constraints that lower their productivity.
The preventive effects of Chlorhexidine mouth wash on alpha- hemolytic Streptococci and Staphylococcus aureus

Dents1390@gmail.com Abstract Background and objectives: The association of oral micro-organisms with infectious diseases such as bacterial endocarditis is a concern in dentistry. Bacterial endocarditis is a serious disease with a mortality rate of 40%. The present study was conducted to investigate the effect of using chlorhexidine mouthwash on concentrations of some groups of bacteria in gingival sulcus, which is the main contact point of oral flora with circulating blood during scaling. Methods: In this Randomized controlled clinical trial, participants were selected among referrals to the department of gingival diseases of Yazd dental school. Participants underwent determining plaque index and after scaling, sampling of the buccal and lingual gingival groove of mandibular central and lateral teeth was performed by paper with walking movement. Results: participants were 53 patients who divided into two groups. Group A consisted of 27 patients (15 women and 12 men) ranging in age from 21 to 54 years mean of 35) who used 50 mL chlorhexidine mouthwash and Group B consisted of 26 patients (13 females and 13 males) ranging in age from 19 to 51 years old with a mean of 35.76 who used 50 mL normal saline before scaling. Study groups were not significantly different in terms of age, sex and plaque index. (P-values= 0.755, 0.348 and 0.708). Mann WhitneyWilcoxon test compared the counted values of Streptococcus viridance and Staphylococcus aureus in control group was significantly higher than the study group. (P-value = 0.000). Conclusion: according to the results of our study chlorhexidine mouthwash prior to scaling teeth significantly reduced Streptococcus viridance and Staphylococcus aureus colony counts and could be recommended as a complementary agent for antibiotic prophylaxis in high risk patients prone to endocarditis, or as the only agent in moderate risk cardiac patients that antibiotic prophylaxis does not been used.
Interleukin-6 and JAK 2 / STAT 3 signaling mediate the reversion of dexamethasone resistance after dexamethasone withdrawal in 7 TD 1 multiple myeloma cells

We previously reported the establishment and characteristics of a DXM-resistant cell line (7TD1DXM) generated from the IL6-dependent mouse B cell hybridoma, 7TD1 cell line. After withdrawing DXM from 7TD1-DXM cells over 90 days, DXM significantly inhibited the cell growth and induced apoptosis in the cells (7TD1-WD) compared with 7TD1-DXM cells. Additionally, IL-6 reversed while IL-6 antibody and AG490 enhanced the effects of growth inhibition and apoptosis induced by DXM in 7TD1-WD cells. Our study demonstrates that 7TD1DXM cells become resensitized to DXM after DXM withdrawal, and IL-6 and JAK2/STAT3 pathways may regulate the phenomenon.
Fatal Avian Influenza A H 5 N 1 in a Dog

H pathogenic avian influenza (HPAI) H5N1 has spread across Asia, Europe, and Africa. Not limited to poultry, the virus has also been shown to cross the species barrier infecting humans (1) and felines, including domestic cats (2) and tigers (3–5). Both cats and tigers were reported as becoming infected after eating poultry carcasses harboring HPAI. Here, we report a case of HPAI H5N1 infection in a domestic dog following ingestion of the carcass of an infected duck.
Carbonatites , isotopes and evolution of the subcontinental mantle : An overview

1 Ottawa-Carleton Geoscience Centre, Department of Earth Sciences, Carleton University, Ottawa, ON, Canada, K1S 5B6 2 Present address: British Columbia Geological Survey, 1810 Blanshard Street, Victoria, BC, Canada V8W 9N3 3 Geological Survey of Canada, 601 Booth Street, Ottawa, ON, Canada, K1A 0E84 4 Present address: Research School of Earth Sciences and Planetary Science Institute, The Australian National University, Canberra ACT0200, Australia a corresponding author: alexei.rukhlov@gov.bc. ca
Title: Diagnosis of Interstitial Cystitis / Bladder Pain Syndrome in Women with Chronic Pelvic Pain: A Prospective Observational Study. Authors:

Introduction and hypothesis: This study assesses the prevalence of interstitial cystitis (IC)/bladder pain syndrome (BPS) in women with chronic pelvic pain (CPP). Methods: A prospective study of 150 women undergoing laparoscopy as investigation for CPP in an Endometriosis and Pelvic Pain unit. Preoperative questionnaires (included demographic details, pelvic pain symptoms, the Pelvic Pain and Urgency/Frequency (PUF) and O'Leary-Sant (OLS) Symptom and Problem Index scores) were completed and concurrent standardised cystoscopy with hydrodistension performed at the laparoscopy. The primary outcome measures the proportion of IC in this group, defined by presence of glomerulations with CPP and urinary symptoms (urinary frequency, nocturia or urgency). The secondary outcome measures the proportion of BPS (defined by the European Society of the Study of Interstitial Cystitis, ESSIC). Results: IC was diagnosed in 48/150 (32%) subjects and 80/150 (53%) had BPS. There were no significant differences in symptomatology or questionnaire results between the groups with and without IC. Women with BPS had higher PUF (17.2 vs 12.9, p<0.001), OLS Symptom (8.2 vs 6.0, p=0.001) and Problem (7.5 vs 4.2, p<0.001) scores and more severe pain symptoms.
Comparative study between the structural and tectonic situation of the Southern Sinai and the Red Sea , Egypt , as deduced from magnetic , gravity and seismic data

The present study is concerned with the analysis of magnetic gravity and seismic data for the regions of the South Sinai and the Red Sea areas aiming to evaluate the subsurface geologic active structures. The magnetic method of prospecting gives an effective presentation of the subsurface structures. Moreover, the wavenumber filtering is carried out utilizing three types of filters with varying wavelengths. The application of these tools on the magnetic and gravity data discriminated the variable sources of specific depth ranges for the residual and regional anomalies, as well as those limited to a certain depth interval. Also it was found that the main tectonic trends have taken the NE–SW and NW–SE directions. A three-dimensional (3D) interpretation of the Bouguer anomaly and aeromagnetic maps of the Gulf of Suez rift and the northern part of the Red Sea rift are presented. A high-resolution 3D model constrained with the seismic results reveals a possible crustal thickness and density distribution of the north Red Sea rift between the sedimentary cover and the mantle.
Screening of probiotics from the digestive tract of gouramy ( Osphronemus goramy ) and their potency to enhance the growth of tilapia ( Oreochromis niloticus )

The aims of this study were to select probiotic candidates from the digestive tract of gouramy (Osphronemus goramy) and to evaluate their potency in improving the growth of tilapia (Oreochromis niloticus). Bacteria were isolated from the digestive tract of gouramy and were selected based on proteolytic, amylolytic and cellulolytic activity, sensitivity to antibiotics, resistance to pH 2.5 and 7.5, antagonistic activity, adhesion ability and pathogenicity test to the host. Further evaluation of probiotics ability in increasing the growth of tilapia had been conducted. The results showed that from 10 isolates obtained, only three isolates were qualified as probiotics (UG3, UG7 and UG8). These probiotic candidates had values of proteolytic index (0.41, 0.24 and 0.43), cellulolytic index (3.4, 4.0 and 3.5) and amylolytic index (0.58, 0.57 and 0.47). Those isolates were sensitive to ampicillin, tetracycline and chloramphenicol, had ability to survive at pH 2.5 and 7.5, and had antagonistic activity against Aeromonas hydrophila with the inhibition zone range around 8-9 mm. These isolates could adhere on a stainless steel plate and were not pathogenic to the fish. In addition, these isolates significantly increased feed efficiency and daily growth rate of tilapia.
Influence of the black-box approach on preservice teachers’ preparation of geometric tasks

The nature of geometric tasks that students engage with in classrooms influences the development of their geometric thinking. Although mathematics standards emphasize formal proofs and mathematical reasoning skills, geometric tasks in classrooms remain focused on students’ abilities to recall mathematical facts and use simple procedures rather than conceptual understanding. In order to facilitate students’ high-level mathematical thinking, teachers need to provide sufficient opportunities for students to engage in cognitively demanding mathematical tasks. The use of dynamic geometry software (DGS) in classrooms facilitates conceptual understanding of geometric proofs. The black box approach is a new type of task in which students interact with pre-constructed figures to explore mathematical relationships by dragging and measuring geometric objects. This approach is challenging to students because it “requires a link between the spatial or visual approach and the theoretical one” (Hollebrands, Laborde, & Sträßer, 2008, p. 172). This study examined how preservice secondary mathematics teachers make choices or create geometric tasks using DGS in terms of cognitive demand levels and how the black box approach influences the way preservice teachers conceptualize their roles in their lesson designs. Three preservice secondary mathematics teachers who took a semester-long mathematics teaching course participated in this qualitative case study. Data include two lesson plans, before and after instructions for geometric DGS tasks, preand post-interview transcripts, electronic files of geometric tasks, and reflection papers from each participant. The Mathematical Task Framework (Stein, Smith, Henningsen, & Silver, 2009) was used to characterize mathematical tasks with respect to level of cognitive demand. A Variety of geometric task types using DGS was introduced to the participants (Galindo, 1998). The
Globally-asynchronous, Locally-synchronous Wrapper Configurations For

Globally-Asynchronous, Locally-Synchronous (GALS) design techniques employ the finer points of synchronous and asynchronous design methods to eliminate problems arising due to clock distribution, power dissipation, and large area over head. With the recent rise in the demand for System-on-a-Chip (SoC) designs, global clock distribution and power dissipation due to clock distribution are inevitable. In order to reduce/eliminate the effects of the global clock in synchronous designs and large area overhead in asynchronous designs, an alternative approach would be to utilize GALS design techniques. Not only do GALS designs eliminate the issue of using a global clock, they also have smaller area overhead when compared to purely asynchronous designs. Among the various GALS design approaches proposed till date, this thesis focuses on the working and implementation of Asynchronous Wrapper designs proposed by Muttersbach et al., in [1, 2]. This thesis specifically addresses different approaches to incorporate the wrappers in VLSI circuits, rather than discussing the efficiency and viability of GALS design techniques over purely synchronous or asynchronous approaches. It has been proven by researchers [3] that GALS design approaches bring down power consumption due to the elimination of the global clock by small amounts, but there is also a drop in performance. Since the goal of this thesis is to introduce the reader to GALS design techniques and not prove their efficiency, it is out of the scope of this thesis to validate the results shown in [3]. In our aim to introduce the reader to GALS design techniques, we first provide a comparison of synchronous and asynchronous design approaches, and then discuss the need for
β 2 integrins are required for skin homing of primed T cells but not for priming naive T cells

β2 integrins are a group of heterodimeric molecules, including LFA-1 (CD11a–CD18), Mac-1 (CD11b–CD18), and p150,95 (CD11c–CD18), which are involved in leukocyte adhesion and in antigen-specific activation of T lymphocytes (1–3). These cell–cell interactions are generally mediated by binding to intercellular adhesion molecule-1 (ICAM-1) and related molecules. In addition, β2 integrins serve as multifunctional receptors for a variety of mammalian and microbial glycoproteins, including serum proteins, lectins, and nucleic acids (4–6). At present, four different β2 integrins have been characterized, all of which are heterodimeric cell-surface molecules consisting of the CD18 molecule and one of the CD11 molecules: CD11a, -b, -c, or -d. CD11a–CD18 is expressed primarily on lymphocytes. CD11b–CD18 is expressed on natural killer cells, monocytes, macrophages, granulocytes, and dendritic cells (DCs). CD11c–CD18 is primarily expressed on DCs, and CD11d–CD18 appears to be expressed on macrophages and lymphocytes (7–9). The human disease known as leukocyte adhesion deficiency type I (LAD I) is characterized by a mutated CD18 molecule, resulting in absent or nonfunctional β2 integrins. Patients suffering from LAD I exhibit leukocytosis, recurrent microbial infections, and defective wound healing (10). We recently generated CD18-deficient mice, which exhibit a phenotype similar to that of LAD I patients and show massive leukocytosis, hyperimmunoglobulinemia, impaired neutrophil extravasation, and spontaneous skin ulcerations. In addition, CD18-deficient mice exhibit defects in formation of aggregates between T cells and antigen-presenting cells (APCs), and in proliferative responses of T cells to alloantigen in vitro (11). Since β2 integrins are involved in various aspects of innate and antigen-specific adaptive immune responses, we were interested in the role of these molecules in antigen-specific, T cell–mediated immune responses in vivo. For this purpose, we investigated the capacity of T cells and DCs to extravasate into inflamed tissue, and used various cutaneous immune responses as experimental models (12). We demonstrate that: (a) T cells from CD18-deficient mice are spontaneously activated in situ; (b) CD18-deficient mice are unable to mount allergic contact dermatitis (ACD) and delayed-type hypersensitivity (DTH) responses, but β2 integrins are not required for priming of naive T cells in vivo; (c) extravasation of T cells and granulocytes, but not of mononuclear cells, into sites of cutaneous inflammation is dependent upon
Enhancing School-Home Communication through Learning Management System Adoption: Parent and Teacher Perceptions and Practices.

Communication is an integral component for establishing a strong school community. Learning management systems (LMSs) present new opportunities for communication and collaboration among teachers, students, and parents. This study examined parents’ and teachers’ perceptions and use of a newly adopted LMS for school–home communication in a rural K–12 school district. Findings indicate that most families have internet access and that parents and teachers are comfortable using digital tools to communicate. Although new tools are available, more traditional resources like email and phones continue to be used most frequently for bidirectional communication. However, results demonstrate that the LMS may provide value as a one-stop location for resources and information.
A Review of the Literature on the Expansion of China’s Firms to Latin America Dr Gaston Fornes University of Bristol (UK) and ESIC Business and Marketing School (Spain)

This paper aims to review and analyse the literature on the expansion of Chinese firms to Latin America. In order to achieve this objective, it first reviews the literature on the internationalisation of Chinese MNCs, the theoretical frameworks discussed in the literature and the principal features of companies from China. Second, it describes the economic and political relations between the countries, specifically the threats and opportunities for Latin America and the trade and investment trends. The review shows that the majority of the current literature on Chinese MNCs has a focus on their expansion to developed countries, on the conceptual framework needed to understand this expansion, and on the competition for foreign investments from developed countries. As a result, the analysis makes evident that research gaps seem to exist in the following areas: (i) the relative value of Chinese companies’ existing advantages, (ii) the sustainability of these advantages once the lead, probably given by OEMs or JVs, had been exhausted, (iii) research works based on quantitative and comparative data, (iv) the motives for FDI, (v) the entry mode, configuration, control and strategy of Chinese companies investing in Latin America, and (vi) the potential opportunities presented to European companies operating in Latin America.