Miracle-dz/UniFAR-FTUs huggingface dataset:
The Demand for Off-grid Solar Power : Evidence from Rural India ’ s Surprisingly Competitive Retail Power Market ∗

Over a billion people, nearly all in South Asia and Sub-Saharan Africa, do not have electricity in their homes. Solar technology has advanced and panels have come down sharply in price, making off-grid, distributed solar systems a feasible alternative to grid electrification. What has been the value of this wave of solar innnovation for the poor? This paper reports the results of a randomized-control trial that offered off-grid solar systems at varying prices in one hundred sparsely electrified villages in Bihar, one of India’s poorest states. We find that demand for solar is highly price elastic and is near zero at un-subsidized 2013 prices. The high price elasticity appears to be due to a surprisingly competitive retail market where the grid and diesel generator operators compete with offgrid solar. To value solar in this competitive landscape and under counterfactual supply conditions, we estimate a discrete choice demand system for electricity sources using the experimental variation in solar prices. We find that the average household (solar user) is willing to pay USD 2 (USD 6) per year for solar if the grid is absent and USD 0.20 (USD 2) if the grid is present. The willingness to pay for off-grid solar is therefore ten times as large if the grid is not available as a substitute.
Reactive Oxygen Species Deficiency Due to Ncf1-Mutation Leads to Development of Adenocarcinoma and Metabolomic and Lipidomic Remodeling in a New Mouse Model of Dextran Sulfate Sodium-Induced Colitis

Inflammatory bowel disease is characterized by chronic relapsing idiopathic inflammation of the gastrointestinal tract and persistent inflammation. Studies focusing on the immune-regulatory function of reactive oxygen species (ROS) are still largely missing. In this study, we analyzed an ROS-deficient mouse model leading to colon adenocarcinoma. Colitis was induced with dextran sulfate sodium (DSS) supplied via the drinking water in wild-type (WT) and Ncf1-mutant (Ncf1) B10.Q mice using two different protocols, one mimicking recovery after acute colitis and another simulating chronic colitis. Disease progression was monitored by evaluation of clinical parameters, histopathological analysis, and the blood serum metabolome using 1H nuclear magnetic resonance spectroscopy. At each experimental time point, colons and spleens from some mice were removed for histopathological analysis and internal clinical parameters. Clinical scores for weight variation, stool consistency, colorectal bleeding, colon length, and spleen weight were significantly worse for Ncf1 than for WT mice. Ncf1 mice with only a 7-day exposure to DSS followed by a 14-day resting period developed colonic distal high-grade dysplasia in contrast to the low-grade dysplasia found in the colon of WT mice. After a 21-day resting period, there was still β-catenin-rich inflammatory infiltration in the Ncf1 mice together with high-grade dysplasia and invasive well-differentiated adenocarcinoma, while in the WT mice, high-grade dysplasia was prominent without malignant invasion and only low inflammation. Although exposure to DSS generated less severe histopathological changes in the WT group, the blood serum metabolome revealed an increased fatty acid content with moderate-to-strong correlations to inflammation score, weight variation, colon length, and spleen weight. Ncf1 mice also displayed a similar pattern but with lower coefficients and showed consistently lower glucose and/or higher lactate levels which correlated with inflammation score, weight variation, and spleen weight. In our novel, DSS-induced colitis animal model, the lack of an oxidative burst ROS was sufficient to develop adenocarcinoma, and display altered blood plasma metabolic and lipid profiles. Thus, oxidative burst seems to be necessary to prevent evolution toward cancer and may confer a protective role in a ROS-mediated self-control mechanism.
Re-examining power and privilege in collective impact

Abstract The dual purpose of this article is to deconstruct the collective impact approach’s treatment of power and privilege while reconstructing the model’s potential to encourage equity agendas in community change. Drawing on discourse analysis of three articles describing collective impact and case studies of two equity-oriented partnerships, analyses explore entry points for framing collective impact in ways that encourage equity as a foundation to partnership practices. Analyses suggest that the original descriptions of the approach referenced by community partners promote the marketization of change and a universal view of success, which mask opportunities to draw on the strengths of individuals and address the distribution of resources. However, partners in two communities in the US were able to use shared measurement practices to layer equity agendas onto the approach. Partners in these cases went beyond the guidance provided through the collective impact approach’s tenets at the advice of funders and community partners.
Biogeochemical Approaches to Assess PAH Pollution in an Urban Waterway

Biogeochemical approaches were applied to enhance the study on polycyclic aromatic hydrocarbon (PAH) pollution in an urban waterway. Chemical characterizations of PAHs in the studied area were identified, geochemical factors were revealed, and related mechanisms were discussed. It was found that, during summer, an early diagenetic process in the sediment could play a major role for the existence of high PAH concentrations, especially high molecular weight PAHs (≥4 rings), in the water column and sediment porewater. This effect could vary with tidal cycling, and higher PAH concentration in the water column would be expected during low tide. Other potential pollution sources were also evaluated in the studied creek. Results showed that pyrogenic sources dominated in the creek, generally. Nevertheless, petroleum products from a metal recycling plant could be an important point source to the waterway during wet weather. Comparing with previous studies in other waterways of the same watershed and published literature suggested that the limited toxicity to the ecosystem was only detected in sediments. More information needs to be collected during low tide for a more objective evaluation of PAH toxicity in the creek.
Reduced lattice thermal conductivity of Fe‐bearing bridgmanite in Earth's deep mantle

Complex seismic, thermal, and chemical features have been reported in Earth's lowermost mantle. In particular, possible iron enrichments in the large low shear‐wave velocity provinces (LLSVPs) could influence thermal transport properties of the constituting minerals in this region, altering the lower mantle dynamics and heat flux across core‐mantle boundary (CMB). Thermal conductivity of bridgmanite is expected to partially control the thermal evolution and dynamics of Earth's lower mantle. Importantly, the pressure‐induced lattice distortion and iron spin and valence states in bridgmanite could affect its lattice thermal conductivity, but these effects remain largely unknown. Here we precisely measured the lattice thermal conductivity of Fe‐bearing bridgmanite to 120 GPa using optical pump‐probe spectroscopy. The conductivity of Fe‐bearing bridgmanite increases monotonically with pressure but drops significantly around 45 GPa due to pressure‐induced lattice distortion on iron sites. Our findings indicate that lattice thermal conductivity at lowermost mantle conditions is twice smaller than previously thought. The decrease in the thermal conductivity of bridgmanite in mid‐lower mantle and below would promote mantle flow against a potential viscosity barrier, facilitating slabs crossing over the 1000 km depth. Modeling of our results applied to LLSVPs shows that variations in iron and bridgmanite fractions induce a significant thermal conductivity decrease, which would enhance internal convective flow. Our CMB heat flux modeling indicates that while heat flux variations are dominated by thermal effects, variations in thermal conductivity also play a significant role. The CMB heat flux map we obtained is substantially different from those assumed so far, which may influence our understanding of the geodynamo.
Coevolution of Mobile Malware and Anti-Malware

Mobile malware is one of today’s greatest threats in computer security. Furthermore, new mobile malware is emerging daily that introduces new security risks. However, while existing security solutions generally protect mobile devices against known risks, they are vulnerable to as yet unknown risks. How anti-malware software reacts to new, unknown malicious software is generally difficult to predict. Therefore, anti-malware software is in continuous development in order to be able to detect new malware or new variants of existing malware. Similarly, as long as anti-malware software develops, malware writers also develop their malicious code by using various evasion strategies, such as obfuscation and encryption. This is the lifecycle of malicious and anti-malware software. In this paper, the use of evolutionary computation techniques are investigated, both for developing new variants of mobile malware which successfully evades anti-malware systems based on static analysis and for developing better security solutions against them automatically. A coevolutionary arms race mechanism has always been considered a potential candidate for developing a more robust system against new attacks and for system testing. To the best of the authors’ knowledge, this paper is the first application of coevolutionary computation to address this problem.
Seismic and Geodetic Evidences of a Hydrothermal Source in the Md 4.0, 2017, Ischia Earthquake (Italy)

Seismic events characterize active hydrothermal and volcanic areas and may be due to magma/fluid migration, hydrothermal pressurization, gravitational instability, and local tectonics. On 21 August 2017, an Md 4.0 earthquake occurred at Ischia volcanic island (Italy), within an active hydrothermal system. We analyze seismic, Global Positioning System, and interferometric synthetic aperture radar data to shed light on the source mechanism of such an event. The low‐frequency content (2 Hz), the low stress drop (0.01 MPa), and a low S/P spectral ratio suggest the involvement of fluids in the source mechanism. The focal mechanism suggests a mixed shear‐tensile (opening) rupture with the P first arrivals showing up movements in the nearest stations. Geodetic data describe an E‐W elongated area of coseismic subsidence overlapping a WSW‐ENE fault bounding the hydrothermal reservoir at depth. The modeled deformation field is consistent with a two‐source model consisting of a WSW‐ESE striking, north dipping normal fault, and a closing subhorizontal crack. This closure immediately followed an initial opening related to a fluid pressurization event responsible for the earthquake. We show that moderate magnitude earthquakes in active hydrothermal areas may be associated with the pressurization/depressurization cycles of a hydrothermal reservoir due to self‐sealing processes and not to the arrival of new fluids from depth. Other events like that recorded at Ischia, which have affected the island in historical times, are not necessarily associated with ‘volcanic unrest’ episodes and imply the occurrence of fault‐valve mechanisms. Therefore, the dynamics of hydrothermal systems must be taken into account in the seismic hazard evaluation.
Increased expression of G9A contributes to carcinogenesis and indicates poor prognosis in hepatocellular carcinoma

Euchromatic histone-lysine N-methyltransferase (G9A), the primary histone methyltransferase for histone H3 Lys9, has been identified to be upregulated in numerous types of cancer. The aim of the present study was to analyze the clinical significance of G9A, and preliminarily explore its function in hepatocellular carcinoma (HCC). An increased expression level of G9A was demonstrated in the HCC samples and also in 5 publically available datasets. By analyzing GSE14520, it was revealed that its expression level was significantly associated with serum α-fetoprotein level of patients with HCC, and may serve as a potential prognostic indicator for patients with multinodular HCC. Bioinformatics tools were utilized to predict the potential function of G9A, and the results indicated that G9A may modulate gene sets involved in RNA processing and DNA replication. G9A inhibition may suppress cell proliferation by arresting cells in G1 phase and increasing the expression level of microtubule-associated protein light chain 3β (MAP1LC3B) in Huh7 and HepG2 cells. In addition, an inverse association between the expression of G9A and LC3B was demonstrated in HCC tumor samples in the publically available GSE14520 dataset, which indicated that G9A may also have the potential to regulate MAP1LC3B expression in HCC tumor tissues. The results of the present study led to hypothesis that the G9A expression level may be of assistance in diagnosing HCC, and be a potential therapeutic target for HCC. The results provided novel evidence for additional understanding of the crucial role of G9A in tumorigenesis.
Relationships Between Self‐Reported and Observed Parenting Behaviour, Adolescent Disordered Eating Attitudes and Behaviours, and the 5‐HTTLPR Polymorphism: Data From the Australian Temperament Project

This study examined whether self-reported and observationally measured parental behaviours were associated with disordered eating, and investigated possible moderation by a serotonin-transporter polymorphism (5-HTTLPR). Study 1 included 650 adolescents from the Australian Temperament Project who completed the Eating Disorder Inventory-2 Drive for Thinness and Bulimia scales at 15/16 years and were genotyped for 5-HTTLPR. Parents completed an Australian Temperament Project-devised measure of parental warmth and harsh punishment. Study 2 included a subgroup of 304 participants who also engaged in a video-recorded family interaction, with observed parental warmth and hostility coded by the Iowa Family Interaction Rating Scale. Greater self-reported parental warmth was associated with lower bulimia scores. Conversely, observationally measured parental warmth was associated with lower drive for thinness, but not bulimia. Self-reported parental harsh punishment was associated with bulimia only, with observed parental hostility associated with neither outcome. 5-HTTLPR genotype did not moderate the relationship between parent behaviours and adolescent disordered eating. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association.
Single-cell whole-genome sequencing identifies human papillomavirus integration in cervical tumour cells prior to and following radiotherapy

Single-cell sequencing technology is a promising systematic and comprehensive approach to delineate clonal associations between cells. The present study collected 13 and 12 cervical cells from fresh tumour tissue prior to and following radiotherapy, respectively, from a 46-year-old female patient with exogenous-type cervical carcinoma. Next, single-cell whole-genome sequencing analysis was performed on each cell. Examination revealed that normal cells could be clearly distinguished from tumour cells among the 25 cells. Tumour cells prior to and following radiotherapy almost represented two independent clones, with the main subpopulation prior to radiotherapy being killed and the minor subpopulation prior to radiotherapy becoming the main subpopulation following radiotherapy. A human papillomavirus (HPV) integration site was detected in POU class 5 homeobox 1B (POU5F1B) in tumour cells following radiotherapy, which has been reported to be a frequent HPV integration site in cervical carcinoma. These results indicate that tumour cells with HPV integration in POU5F1B survive radiotherapy, and that tumour cells prior to and following radiotherapy exhibit distinct characteristics.
Effects of Chitosan on the Secretion of Cytokines and Expression of Inducible Nitric Oxide Synthase mRNA in Peritoneal Macrophages of Broiler Chicken

An in vitro experiment was conducted to study the effects of chitosan on the secretion of cytokines and expression of inducible nitric oxide synthase mRNA in peritoneal macrophages of broiler chicken. In the experiment, peritoneal macrophages were incubated for 24 h in culture medium supplemented with 0 (control), 40, 80, 160 and 320 µg/mL chitosan. The results showed that chitosan tended to increase quadratically the levels of interleukin-1 (P = 0.093) and interleukin-2 (P = 0.106) in the culture fluid of peritoneal macrophage. Chitosan also significantly enhanced inducible nitric oxide synthase mRNA expression of peritoneal macrophage in a quadratic dose-dependent manner (P < 0.05) and tended to promote quadratically the secretion of nitric oxide (P = 0.053) and inducible nitric oxide synthase (P = 0.157) in peritoneal macrophages. This result implied that one of the mechanisms by which chitosan modulated immune functions in chickens might be chitosan activating expression of inducible nitric oxide synthase and then improving the secretion of nitric oxide.
Preoperative predictive model for acute kidney injury after elective cardiac surgery: a prospective multicenter cohort study.

BACKGROUND Predictive models of acute kidney injury after cardiac surgery (CS-AKI) include emergency surgery and patients with hemodynamic instability. Our objective was to evaluate the performance of validated predictive models (Thakar and Demirjian) in elective cardiac surgery and to propose a better score in the case of poor performance. METHODS A prospective, multicenter, observational study was designed. Data were collected from 942 patients undergoing cardiac surgery, after excluding emergency surgery and patients with an intra-aortic balloon pump. The main outcome measure was CS-AKI defined by the composite of requiring dialysis or doubling baseline creatinine values. RESULTS Both models showed poor discrimination in elective surgery (Thakar's model, AUC=0.57, 95% CI: 0.50-0.64 and Demirjian's model, AUC=0.64, 95% CI: 0.58-0.71). We generated a new model whose significant independent predictors were: anemia, age, hypertension, obesity, congestive heart failure, previous cardiac surgery and type of surgery. It classifies patients with scores 0-3 as at low risk (<5%), patients with scores 4-7 as at medium risk (up to 15%), and patients with scores >8 as at high risk (>30%) of developing CS-AKI with a statistically significant correlation (P<0.001). Our model reflects acceptable discriminatory ability (AUC=0.72, 95% CI: 0.66-0.78) which is significantly better than Thakar and Demirjian's models (P<0.01). CONCLUSIONS We developed a new simple predictive model of CS-AKI in elective surgery based on available preoperative information. Our new model is easy to calculate and can be an effective tool for communicating risk to patients and guiding decision-making in the perioperative period. The study requires external validation.
Informality and Flexible Specialization: Labour Supply, Wages, and Knowledge Flows in an Indian Artisanal Cluster

Artisanal industrial clusters, geographical agglomerations of small or micro, â€˜flexibly-specializedâ€™ enterprises, are an important component of the informal sector from employment generation, poverty alleviation, as well as export promotion perspectives. Two theoretical paradigms have commonly been employed to analyse such clusters: informality and flexible specialization. The first paradigm emphasizes precarious work, surplus labour, and low wages; the second, skilled labour, agglomeration economies, and fashion-sensitive products. This study brings these two perspectives together to address how informal institutions enable clusters to function and how they shape the distribution of risks and gains that accompany flexible specialization. Focusing on the artisanal weaving cluster in the city of Banaras, in North India, I examine the putting-out (subcontracting) system, the system of family-based apprenticeships, and the transfer of fabric designs between firms. In each case, I show how informality and flexible specialization complement and contradict each other.
Transplant Glomerulopathy: Morphology, Associations and Mechanism

Transplant glomerulopathy (TG) is a lesion with specific morphology and strong evidence of an immune mechanism. The incidence of TG is approximately 20% by 5 years after transplantation. TG is characterized by proteinuria, hypertension and declining graft function. Appearances on light microscopy include thickened capillary walls and double contours, with reduplication or lamination of the glomerular basement membrane on electron microscopy. TG is associated with acute rejection, the antibody status before transplantation and de novo HLA antibodies. HLA class II and/or donor-specific antibodies incur additional risks. Desensitization protocols do not always prevent the development of TG in highly sensitized individuals. Associations between TG, past or current C4d and the presence of alloantibodies are recognised, however, C4d in the peri-tubular capillaries or glomeruli is not a prerequisite at the time of diagnosis. Clinical observation and animal models suggest that TG arises as a consequence of chronic endothelial cell (EC) injury by the humoral arm of the immune system. In some cases, this follows a period of EC accommodation after an episode of acute injury. Proposed treatments include augmentation of background immunosuppression, and trials of monoclonal therapies targeted at CD20-positive B cells are underway.
A note on rate of eating in sheep

Sheep ate significantly faster during the first 30 min after being offered fresh food when they were fed on ground, pelleted dried grass than when fed on long hay; chopped dried grass was eaten at an intermediate speed. Rate of eating of the unground diets was negatively related to mean retention time and positively related to total voluntary intake. In a second experiment, rate of eating during the 30 min after feeding was significantly faster when hay was fed at two-thirds of the ad libitum rate than when it was fed ad libitum , irrespective of whether penning was individual or in groups of six.
Development, Characterization and Transdermal Delivery of Dapsone and an Antibiotic Entrapped in Ethanolic Liposomal Gel for the Treatment of Lapromatous Leprosy

Received: November 30, 2017 Revised: April 5, 2018 Accepted: April 16, 2018 Abstract: Background and Objective: Applying Ethosomal Gels (EGs) in transdermal drug delivery systems has evoked considerable interest because of their good watersolubility and biocompatibility. The aim of present study was to prepare and characterize ethosomes of antileprotic drug Dapsone (DAP) together with an antibiotic Cloxacillin Sodium (CLXS) which may deliver these drugs to targeted site more efficiently than marketed gel preparation of DAP and also overcome the problems related with oral administration of CLXS.