Miracle-dz/UniFAR-FTUs huggingface dataset:
Relationship Between Morphology, Euploidy and Implantation Potential of Cleavage and Blastocyst Stage Embryos

Aim: The aim of this study was to investigate the relationship between the morphology, euploidy and implantation rate of cleavage stage and blastocyst stage embryos. Setting: Institution-based, tertiary care in-vitro fertilization centre. Study Design: This study included a retrospective data analysis of 306 embryos: 154 cleavage stage embryos and 152 blastocysts that underwent biopsy on day 3 and day 5/6, respectively, which were subsequently screened for aneuploidy by array comparative genomic hybridization analysis. Materials and Methods: Both cleavage stage and blastocyst stage embryos were categorized according to their morphology into the following three groups: good, average and poor. In addition, blastocysts were categorized into day 5 and day 6 embryos on the basis of their developmental rate. Results: The euploidy rate was found to be significantly higher for blastocysts with good morphology as compared to those with poor morphology, with 73.2, 50 and 40.5% euploid embryos in the good, average and poor morphology groups, respectively (P = 0.001). No significant association was found between day 3 embryo morphology and euploidy rates with 40.6, 29.3 and 25.8% euploid embryos in the three groups, respectively (P = 0.254). The implantation rates, as per morphology, for the transferred euploid cleavage stage and blastocyst stage embryos were 43.8, 37.5 and 0% (P = 0.354) and 51.7, 71.4 and 66.7% (P = 0.562) in the good, average and poor morphology groups, respectively. The euploidy rate for day 5 blastocysts was significantly higher (70% vs. 34.1%, P < 0.001) than that of day 6 blastocysts, but the implantation rate was similar in both the groups (58.8 and 50%, respectively). The miscarriage rates for the euploid cleavage stage and the blastocysts stage embryos were 18.2 and 8.3% (P = 0.575), respectively. Conclusion: Blastocyst morphology and the rate of development were found to be significantly associated with euploidy, whereas cleavage stage morphology was not. The implantation rates of the good quality, euploid cleavage stage embryos were higher than that of the poor quality embryos. The implantation rates were similar for all transferred euploid blastocysts, irrespective of their morphology or the rate of development.
Efficacy of low level laser therapy and intramuscular electrical stimulation on myofascial pain syndrome.

BACKGROUND Myofascial pain syndrome (MPS) which is an important cause of musculoskeletal pain has shown a dramatic increase in recent years. OBJECTIVES We aimed to evaluate the efficacy of intramuscular electrical stimulation therapy (IMS) and low-level-lasertherapy (LLLT) in patients with MPS. METHODS Patients were randomly divided into three groups. First group were treated with LLLT and stretching exercise. Second group were treated with IMS and stretching exercise. Third group were treated with only stretching exercise. The patients were evaluated through the pain intensity, pain threshold, cervical joint movement range and the neck disability index parameters. RESULTS An improvement was found in all parameters for all groups, except for the pain threshold within the control group at the end of the treatment and one month after the treatment. It was found that pain score was significantly lower in Group 1 and 2 at one month after the treatment compared to Group 3. Similarly, it was found that pain threshold score was significantly higher in Group 2 at one month after the treatment compared to Group 3. CONCLUSIONS In this study we observed that both LLLT and IMS treatments added on to stretching are effective in improving pain parameters in patients with MPS.
Fertility parameters of dairy cows with retained placenta or endometritis treated with intrauterine povidone iodine foam.

The aim of the study was to evaluate the reproductive indices in cows with retained placenta and endometritis in response to D-cloprostenol or povidone iodine (PI) foam treatment, as well as bacterial clearance and histopathological changes after PI foam intrauterine administration. The examinations were performed on a total of 113 Brown Swiss dairy cows. In experiment I, cows with retained placenta (n=42) and endometritis (n=50) were administered randomly with either PI foam (2%) (20-150 ml, intrauterine) or PGF2α (150 µg, i.m.). The uterine microbial flora was also monitored in the cows before and after PI foam administration. In experiment II, 21 cows without reproductive diseases were administered with PI foam (20 ml, intrauterine) 10, 20, and 30 d before slaughtering to evaluate the histopathology of the uterine tissue. In the cows with retained placenta, there were no effects from the treatment on the number of days to 1 st service (d), days open (d), 1 st service conception rate (%), and insemination index, which averaged 100, 124, 28.6, and 2.19, respectively. In the cows with endometritis, PI foam administration decreased the number of days to 1 st service and days open - 13 and 17 d - as compared to PGF2α administration, without altering the 1 st service conception rate (26.4%) and insemination index (2.32). E. coli was the most common bacterium in these cows. On days 5 and 15, relative to PI foam administration, 56 and 100% microbial recovery were achieved. Furthermore, no degenerative changes in the laminal epithelium of uterus were detected upon PI foam administration. In conclusion, the microbial recovery and shortened days to 1 st service and days open may suggest that a low level of PI foam can be considered as a therapeutic agent against retained placenta and endometritis.
Intraictal Activation in the Neocortex: A Marker of the Epileptogenic Region

Summary: During the course of a seizure, subdural recordings often show secondary areas which develop in‐dependent electrographic sequences that may outlast the primary seizure sequence. We reviewed the subdural data on 8 patients with intraictal secondarily activated foci (ISF). In 6 patients, ISFs were documented to be capable of generating independent seizures; ISF seizures occurred during the initial subdural monitoring period in 3, but became ictal generators only after excision of the primary focus in the other 3. Prominent interictal abnormalities were observed at the ISFs in 5 of 8 patients. The ISF in 1 patient correlated with the structural lesion on magnetic resonance imaging (MRI) scan. We believe that ISFs have significant epileptogenicity and should be re‐sected when possible.
Getting Students to Earnestly Do Reading, Studying, and Homework in an Introductory Programming Class

Getting students to read and study before class, to be better prepared for lecture, or to enable a flipped classroom is a long-standing difficulty for teachers of introductory programming classes. Furthermore, getting students to do homework, consisting of small practice problems and questions, is also a long-standing difficulty without massive grading resources. And even then, preventing students from copying others' solutions is difficult as well. Today, the web enables new interactive learning material that is replacing past forms of textbooks and homework assignments, and students today commonly have access to needed devices and the internet. This paper provides data on student reading and homework completion rates for web-based interactive learning material we created that automatically records reading and homework activity by students. The data is for several thousand students at over 10 universities, for introductory programming classes in Java, Python, and C++. The data shows that, with an appropriate amount of awarded points, required-reading completion rate was 84%, and auto-graded homework completion rate was 75%, varying somewhat based on how many course grade points those items were worth. Students on average spent about 10 minutes reading each section, and about 3 minutes per homework problem, both appropriate amounts for those items. Furthermore, we developed measures of whether students were earnestly attempting the reading and homeworks, versus just "cheating the system" to get course grade points. We describe those earnestness measures in this paper. With proper design and amount of assigned work, 80%-90% of students earnestly did the reading and homework activities, even when no penalty existed for cheating the system, and fewer than 3% blatantly cheated the system to get their points.
Outcome Of Conservative Management Of Incomplete 1 st Trimester Miscarriage : Observational Study

256 Abstract Background: The principle of emptying the uterus as quickly and safely as possible remains the corner stone of management of incomplete miscarriage. In many countries surgical uterine evacuation is the standard treatment, expectant management has been advocated as an alternative in several observational studies. Objectives: To evaluate the effectiveness of expectant management of incomplete 1st trimester miscarriage. Study design and setting: Prospective observational study carried out at Babylon hospital for maternity and pediatrics between feb.2009-jan. 2010. Materials and methods: The study involved 120 clinically stable patients with incomplete 1st trimester miscarriage (diagnosed by TVU), those patients subjected to conservative examination treatment (no intervention) and follow up for 2 weeks by clinical examination and transvaginal ultrasound. The main outcome measures were complete miscarriage (absence of vaginal bleeding and endometrial thickness 15 mm by TVU), need for emergency curettage, infection and need for blood transfusion. Result: Successful outcome without surgical intervention was seen in of 85% of cases infection reported in 1.6% of cases, emergency curettage needed for 5 % (1.6% for infection and 3.3% for excessive vaginal bleeding), 10% of cases required elective surgical evacuation (4.1% of them refused follow up >1 week and 5.8% to failed to have complete miscarriage after 2 weeks of observation) without reported complications. Conclusion: Expectant management of clinically stable patients with retained product of conception after 1st trimester incomplete miscarriage is safe, effective and well tolerated. لمحلا نم ىلولأا رهشأ ةثلاثلا يف صقانلا ضاهجلاا تلااح جلاع يف يظفحتلا جلاعلا ةيلاعف ةصلاخلا ةمدقملا : ضاـهجلإا تلااـح ةجلاعم يف ساسلأا رجحلا تافعاضم لقلأاو عرسلأا قرطلاب هتايوتحم نم محرلا غارفإ ةيلمع دعت متت ام ابلاغو صقانلا تافعاضملا نم ولخت لا يتلاو ةيحارجلا قرطلا ةطساوب . جلاـعلا ةيلاعف نايب ةديدع تاسارد تلواح دقو يحارجلا لخادتلا نع هب ةضاعتسلاا ةيناكمإ و يظفحتلا . ةساردلا نم فدهلا : لمحلا نم ىلولأا رهشأ ةثلاثلا يف صقانلا ضاهجلإا تلااح يف يظفحتلا جلاعلا ةيلاعف مييقت Outcome Of Conservative Management Of Incomplete 1st Trimester Miscarriage: Observational Study Asmaa K. Gatea College of Medicine, University of Babylon, Hilla, Babylon, Iraq.
Imidacloprid induced osmotic fragility in erythrocytes of rats: Protective role of vit.C and tea

The present study was undertaken to evaluate the effect in vitro induction of sub-acute oral dose of imidacloprid and ameliorating role of tea and Vit.C on oxidative stress and osmotic fragility of albino wistar rats. On the basis of imidacloprid having LD50 450mg/kg body weight in rats, which exert oxidative stress on mammalian system and is moderately toxic via oral route. We observed a significant alteration in osmotic fragility of rat erythrocytes upon imidacloprid treatment shown by mean erythrocyte osmotic fragility at relatively higher NaCl concentration of (0.45%) as compared to mean erythrocyte fragility(MEF) at 0.40%,0.41% 42%,0.32% and 0.30% NaCl in control, Vit. C, tea, IP+ tea, IP + Vit.C treated groups, respectively. The results suggest that imidacloprid induced toxicity exerts OF in erythrocytes of rats and pretreatment with Vit. C and tea can mitigate to some extent the toxic effects.
Ionic Composition of Endolymph and Perilymph in the Inner Ear of the Oyster Toadfish, Opsanus tau

The concentrations of free Na+, K+, Ca2+, and Cl-in endolymph and perilymph from the inner ear of the oyster toadfish, Opsanus tau, were measured in vivo using double-barreled ion-selective electrodes. Perilymph concentrations were similar to those measured in other species, while endolymph concentrations were similar to those measured previously in elasmobranch fish, though significantly different from concentrations reported in mammals. Perilymph concentrations (mean ± std. dev.) were as follows: Na+, 129 mmol l-1 ± 20; K+, 4.96 mmol l-1 ± 2.67; Ca2+, 1.83 mmol l-1 ± 0.27; and Cl-, 171 mmol l-1 ± 20. Saccular endolymph concentrations were Na+, 166 mmol l-1 ± 22; K+, 51.4 mmol l-1 ± 16.7; Ca2+, 2.88 mmol l-1 ± 0.27; and Cl-, 170 mmol l-1 ± 12; and semicircular canal (utricular vestibule) endolymph concentrations were Na+, 122 mmol l-1 ± 15; K+, 47.7 mmol l-1 ± 13.2; Ca2+, 1.78 mmol l-1 ± 0.48; Cl-, 176 mmol l-1 ± 27. The relatively high concentrations of Ca2+ and Na+ in the endolymph may have significant implications for the physiological function of the mechanoelectrical transduction channels in the vestibular hair cells of fish compared to those of their mammalian counterparts.
Short-Term Decline in All-Cause Acquired Infections With the Routine Use of a Decontamination Regimen Combining Topical Polymyxin, Tobramycin, and Amphotericin B With Mupirocin and Chlorhexidine in the ICU: A Single-Center Experience*

Objectives:In a multicenter, placebo-controlled, randomized, double-blind trial, we showed that acquired infections in intubated patients were reduced by the combination of topical polymyxin plus tobramycin and nasal mupirocin plus chlorhexidine body wash. Because intubated patients are particularly at risk for acquired infections, we reassessed the impact of this protocol as a routine procedure to control acquired infections in the ICU. Design:Nonrandomized study comparing acquired infections in ICU patients during two 1-year periods: the last year before (group A, n = 925) and the first year after the implementation of the protocol (group B, n = 1,022). Acquired infections were prospectively recorded. Setting:Polyvalent medical ICU at a university-affiliated hospital. Patients:All patients admitted to the ICU. Interventions:Administration of polymyxin/tobramycin/amphotericin B in the oropharynx and the gastric tube plus a mupirocin/chlorhexidine regimen in intubated patients and standard care in the other patients. Measurements and Main Results:The comparison of acquired infection rates between groups was adjusted for differences at baseline. Infection rates were lower in group B compared with group A (5.3% vs 11.0%; p < 0.001), as were the incidence rates of total acquired infections (9.4 vs 23.6 per 1,000 patient-days; p < 0.001), intubation-related pneumonia (5.1 vs 17.1 per 1,000 ventilator-days; p < 0.001), and catheter-related bloodstream infections (1.0 vs 3.5 per 1,000 catheter-days; p = 0.03). There were fewer acquired infections caused by ceftazidime-resistant Enterobacteriaceae (0.8‰ vs 3.6‰; p < 0.001), ciprofloxacin-resistant Enterobacteriaceae (0.8‰ vs 2.5‰; p = 0.02), ciprofloxacin-resistant Pseudomonas aeruginosa (0.5‰ vs 1.6‰; p = 0.05), and colistin-resistant Gram-negative bacilli (0.7‰ vs 1.9‰; p = 0.04). Fewer patients got acquired infections due to multidrug-resistant aerobic Gram-negative bacilli (p = 0.008). Conclusions:In intubated patients, the use of topical polymyxin/tobramycin/amphotericin B plus mupirocin/chlorhexidine was associated with the reduction of all-cause ICU-acquired infections. Long-term emergence of multidrug-resistant organisms deserves further investigation.
Comparative Study of Various Regression Methods for Software Effort Estimation

Machine Learning deals with the issue of how to build programs that improve their performance at some task through experience. This paper deals with the subject of applying machine learning methods to software engineering. For effort estimation which not only provide an estimation but also confidence interval for it. The robust confidence intervals do not depend on the form of probability distribution of the errors in the training set. This paper compares various regression methods for software effort estimation with the help of number of experiments performed using NASA datasets and to show that robust confidence intervals can be successfully built.
Generation of the vesicular stomatitis virus nucleoprotein cytotoxic T lymphocyte epitope requires proteasome‐dependent and ‐independent proteolytic activities

The proteasome is involved in the generation of most of the MHC class I antigenic epitopes. However, it is not known if the proteasome generates the exact cytotoxic T lymphocyte (CTL) epitope or only epitope precursors which require further modification by additional proteases. Digestion of the extended vesicular stomatitis virus nucleoprotein epitope 52 – 59 (RGYVYQGL) by the 20S proteasome in vitro shows that the proteasome is capable of generating the correct C terminus but not the exact N terminus of the CTL epitope. This finding suggests that proteolytic activity in addition to the proteasome is required for generation of the CTL epitope. By using the proteasome inhibitor lactacystin we were able to confirm this finding in vivo. Lactacystin prevented the processing of N‐ and C‐terminally extended epitopes, whereas the processing of only N‐terminally extended epitopes was unaffected. Thus, the proteasome is necessary and sufficient for the generation of the exact C terminus of this CTL epitope, whereas the exact N terminus seems to be generated by a different protease.
Leaky characteristics of a new omni-directional periodic rod antenna gloved with A LHM shell

A new omni-directional leaky-wave antenna is proposed in the paper, which is consisted of circular rod corrugations gloved with a left-handed material (LHM) shell. The leaky characteristics of the new antenna are analyzed by improved perturbation method. The electromagnetic fields are described in terms of a radial transmission-line network, which tremendously simplifies the analysis procedure with good calculation accuracy and brings considerable physical insight into the overall behavior of the dielectric grating antenna. The case where the n=-1 space harmonic of TE01 mode radiating into the space is carefully investigated, it is demonstrated that the gloved cylindrical LHM shell greatly enhances the leaky strength of the antenna. As a result, the dimension of the antenna could be largely reduced keeping the radiation efficiency unchanged, which is of practical significance for some applications.
Wordsworth’s Profession: Form, Class, and the Logic of Early Romantic Cultural Production

Introduction 1. Description: picturesque aesthetics and the production of the English Middle Class, 1730-1798 2. Instruction: romantic theories of elemental and cultural literacy and the Lyrical Ballads 3. Vocation: automimesis and the political economy of spirit and body in The Prelude Notes Bibliography Index.
Bronchial Carcinoma Treated with Nitrogen Mustard and Cyclophosphamide

Nitrogen mustard (mustine hydrochloride) has been used in the treatment of lung cancer for 20 years. Lynch, Ware, and Gaensler (1950), Kent and Reh (1950), Levine and Weisberger (1955), Hatch, Bradford, and Ochsner (1956), and Bass (1960) have described their experience with this cytotoxic agent and have reported symptomatic improvement in many patients, but little or no prolongation of life. Since 1958, when cyclo phosphamide was synthesized, it has been widely used for malig nant disease, including lung cancer, both palliatively in advanced inoperable disease (Spear and Patno, 1962 ; Braun-Wotke, 1963), and as cover for operation in patients with less-advanced disease (Poulsen, 1962, 1963). Present Investigation Our primary aim was to assess the objective evidence of improvement in patients with bronchial carcinoma treated with nitrogen mustard and cyclophosphamide and to compare the results of the two agents. The secondary aim was to assess the effect of early " follow-up " treatment on the survival time in the patients who had improved. Selection of Patients. The series ran for two years. At first all patients presenting with bronchial carcinoma at two chest clinics were included. After a short time patients who were suitable for operation were excluded because it was feared that cytotoxic therapy might be lowering the pulmonary diffusing capacity. Later investigations did not confirm this suspicion. There were 88 men and 9 women, and alternate male patients were given nitrogen mustard and cyclophosphamide, except at one peripheral hospital where it was difficult to manage intra venous nitrogen-mustard drips and all five male patients had cyclophosphamide. All female patients had nitrogen mustard. Diagnosis. In 36 out of the 48 patients treated with nitrogen mustard and m 37 out of the 49 having cyclophosphamide,
Phytotoxic Activities of Mediterranean Essential Oils

Twelve essential oils from Mediterranean aromatic plants were tested for their phytotoxic activity, at different doses, against the germination and the initial radicle growth of seeds of Raphanus sativus, Lactuca sativa and Lepidium sativum. The essential oils were obtained from Hyssopus officinalis, Lavandula angustifolia, Majorana hortensis, Melissa officinalis, Ocimum basilicum, Origanum vulgare, Salvia officinalis and Thymus vulgaris (Lamiaceae), Verbena officinalis (Verbenaceae), Pimpinella anisum, Foeniculum vulgare and Carum carvi (Apiaceae). The germination and radicle growth of tested seeds were affected in different ways by the oils. Thyme, balm, vervain and caraway essential oils were more active against both germination and radicle elongation.
Effects of Freemium Strategy in the Mobile App Market: An Empirical Study of Google Play

Abstract This paper examines the effect of the freemium strategy on Google Play, an online marketplace for Android mobile applications. By analyzing a large panel data set consisting of 711 ranked mobile apps, we found that the freemium strategy is positively associated with increased sales of the paid mobile apps. Positive trial experience as represented by high review rating of the free version of a mobile app leads to higher sales of its paid version, whereas high visibility of the free version of a mobile app as represented by its product rank does not have a significant impact on the sales of its paid version. This finding suggests that although offering a free trial version is a viable way to improve the visibility of a mobile app, offering a quality free app is more important in boosting sales of the paid app. Moreover, we found that the impact of review rating is reduced when the free version is offered, or when the mobile app is a hedonic app, because consumers have the ability to experience the app themselves before purchase. These findings extend understanding of the freemium business model to include a market characterized by simultaneous intramarket competition for both the freemium and paid products and demonstrate how such dynamics may influence sales of the paid products.