Miracle-dz/UniFAR-FTUs huggingface dataset:
Occurrence of atopy among Russian and Finnish schoolchildren

Allergic rhinitis is becoming one of the leading factors in the aetiology of Eustachian tube dysfunctions (1). Nasal inflammation due to allergen challenge results in classic signs and symptoms of allergic rhinitis and Eustachian tube dysfunction, leading to increased negative pressure and improper ventilation in the middle ear (2, 3). Those patients who have to undergo middle ear surgery may suffer from allergic rhinitis. An allergic relapse in patients recently submitted to middle ear surgery can have serious consequences, like an increased risk of barotraumas after minimal pressure changes (diving, post-operative air travels) and an operation failure because of recurrent acute or chronic middle ear ventilation impairment (4). Even in the best super-specialized ear clinics, most allergic patients with middle ear diseases undergo middle ear surgery without a complete assessment of the rhino-pharyngeal-tubal unit and possible allergic conditions. We conducted a revision of the most important studies published in the last years on outcomes in middle ear surgery; surprisingly, nobody considered the presence of allergic rhinitis either as an exclusion criteria, or as an influencing factor on middle ear surgery results, or as a pathology to be treated before (5–8). We deem that allergic patients candidate to middle ear surgery have to be followed by an equipe of ENT doctors and allergologists, to prepare them to surgery in order to achieve better results. We know that in the most successful case histories of tympanoplasty, the posttympanoplastic flap takes root at a rate of almost 90%, and the prevalence of allergic rhinitis ranges from 9 to 42% (9). In our experience, most cases of failure occurred in patients with tubal dysfunction for chronic nasal obstruction. Allergic rhinitis is one of the main causes of chronic nasal obstruction. It is possible that most failures in tympanoplasty are due to an underestimated allergic rhinitis, isn’t it?
Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction.

BACKGROUND Type 2 (non-insulin-dependent) diabetes is associated with a marked increase in the risk of coronary heart disease. It has been debated whether patients with diabetes who have not had myocardial infarctions should be treated as aggressively for cardiovascular risk factors as patients who have had myocardial infarctions. METHODS To address this issue, we compared the seven-year incidence of myocardial infarction (fatal and nonfatal) among 1373 nondiabetic subjects with the incidence among 1059 diabetic subjects, all from a Finnish population-based study. RESULTS The seven-year incidence rates of myocardial infarction in nondiabetic subjects with and without prior myocardial infarction at base line were 18.8 percent and 3.5 percent, respectively (P<0.001). The seven-year incidence rates of myocardial infarction in diabetic subjects with and without prior myocardial infarction at base line were 45.0 percent and 20.2 percent, respectively (P<0.001). The hazard ratio for death from coronary heart disease for diabetic subjects without prior myocardial infarction as compared with nondiabetic subjects with prior myocardial infarction was not significantly different from 1.0 (hazard ratio, 1.4; 95 percent confidence interval, 0.7 to 2.6) after adjustment for age and sex, suggesting similar risks of infarction in the two groups. After further adjustment for total cholesterol, hypertension, and smoking, this hazard ratio remained close to 1.0 (hazard ratio, 1.2; 95 percent confidence interval, 0.6 to 2.4). CONCLUSIONS Our data suggest that diabetic patients without previous myocardial infarction have as high a risk of myocardial infarction as nondiabetic patients with previous myocardial infarction. These data provide a rationale for treating cardiovascular risk factors in diabetic patients as aggressively as in nondiabetic patients with prior myocardial infarction.
Antineutrophil cytoplasmic antibody‐associated glomerulonephritis in Taiwanese

Aims: This retrospective study defined the clinical features and outcome of antineutrophil cytoplasmic antibody‐associated glomerulonephritis in 18 seropositive Taiwanese patients (11 male, seven female; median age 64 years; range 21–82 years) with biopsy‐proven pauci‐immune necrotizing crescentic glomerulonephritis.
Advances in Brief Geldanamycin Induces Degradation of Hypoxia-inducible Factor 1 Protein via the Proteosome Pathway in Prostate Cancer Cells 1

Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor composed of and subunits. HIF-1 is critically involved in cellular responses to hypoxia, glycolysis, and angiogenesis. Here, we show that treatment of prostate cancer PC-3 and LNCaP cells with the benzoquinone ansamycin geldanamycin, an Hsp90-specific inhibitor, induced degradation of HIF-1 protein in a doseand time-dependent manner under both normoxia and hypoxia. This inhibition was also shown in other common cancer types tested. Rapid degradation of nuclear HIF-1 protein levels was accompanied by respective inhibition in HIF-1 functional transcription activity of VEGF. No difference between HIF-1 mRNA levels before or after geldanamycin treatment was found. Moreover, [S]methionine pulse-chase analysis revealed that HIF-1 protein halflife was markedly decreased in the presence of geldanamycin compared with that in control. The geldanamycin-induced degradation of HIF-1 was reversed by proteosome inhibitors lactacystin and MG-132. We conclude that geldanamycin induces reduction of HIF-1 levels and its downstream transcriptional activity by accelerating protein degradation independent of O2 tension. Thus, benzoquinone ansamycin drugs and their derivatives, such as 17-allyl-aminogeldanamycin, are excellent candidates as small molecule drug inhibitors of HIF-1 overexpression in cancer cells.
How to make a spaghetti sauce with a dozen small things I cannot name: A review of the impact of semantic-memory deficits on everyday actions

The purpose of this article is to present current evidence regarding the role of semantic memory in everyday actions. First we describe key models of everyday actions. We then discuss current evidence regarding the role of semantic memory in everyday actions. We reviewed articles reporting on the execution and representation of everyday actions in populations with semantic-memory deficits and single-object use in patients with semantic dementia. Although the evidence is sparse, the general conclusion of this review is that semantic memory seems necessary to support everyday actions. Finally, future challenges and research perspectives are discussed.
A study on factors influencing ferroresonance in distribution system

Ferroresonance due to transient impact is a common phenomenon in ungrounded distribution system. It is a great threat to the security of power system. Highly nonlinear magnetizing inductance of the potential transformer and zero sequence capacitance of the system may cause low, high or fundamental frequency resonance. On the basis of analyzing the mechanism of ferroresonance, an equivalent model of a 10kV distribution system is established. A simulation model of the 10kV distribution system is built using saturable transformer model in MATLAB\Simulink. Simulation results reveal as follows: zero sequence capacitance of the system determines types of ferroresonance caused by single phase-to-ground fault; magnetizing resistance, DC resistance of the high-voltage winding and magnetizing characteristic of the potential transformer principally determine whether ferroresonance occurs or not and its amplitude.
Underlying purinergic signaling contributes to T lymphocyte activation in tissue repair. Focus on "shockwaves increase the T-cell proliferation and IL-2 expression through ATP release, P2X7 receptors, and FAK activation".

even though i have worked in the “purinergic field” for a number of years, I continue to be amazed by the range of cellular and tissue systems and experimental settings in which purinergic signaling (i.e., extracellular signaling by ligands such as ATP, ADP, 5′-AMP, and/or adenosine) is
Blood flow velocity measurements: a comparison of 25 clinical ultrasonographic units.

A blood‐mimicking flow phantom was used to evaluate the precision of velocity measurements acquired using 25 pulsed Doppler ultrasonographic units from four vendors. Measurements were made at four constant flow rates (12 to 50 cm/s peak velocity). The average standard deviation values of the peak and time‐averaged velocities among all units and all flow rates were found to be 7 and 9% of the mean, respectively, while the corresponding values for a subgroup of 20 identical units were 5 and 8%. Considered in conjunction with other published data, this suggests that units should be calibrated to an institutional standard at the time of acceptance testing.
In Vitro Activity of Riboflavin against the Human Malaria Parasite Plasmodium falciparum

ABSTRACT The human malaria parasite Plasmodium falciparumdigests hemoglobin and polymerizes the released free heme into hemozoin. This activity occurs in an acidic organelle called the food vacuole and is essential for survival of the parasite in erythrocytes. Since acidic conditions are known to enhance the auto-oxidation of hemoglobin, we investigated whether hemoglobin ingested by the parasite was oxidized and whether the oxidation process could be a target for chemotherapy against malaria. We released parasites from their host cells and separately analyzed hemoglobin ingested by the parasites from that remaining in the erythrocytes. Isolated parasites contained elevated amounts (38.5% ± 3.5%) of oxidized hemoglobin (methemoglobin) compared to levels (0.8% ± 0.2%) found in normal, uninfected erythrocytes. Further, treatment of infected cells with the reducing agent riboflavin for 24 h decreased the parasite methemoglobin level by 55%. It also inhibited hemozoin production by 50% and decreased the average size of the food vacuole by 47%. Administration of riboflavin for 48 h resulted in a 65% decrease in food vacuole size and inhibited asexual parasite growth in cultures. High doses of riboflavin are used clinically to treat congenital methemoglobinemia without any adverse side effects. This activity, in conjunction with its impressive antimalarial activity, makes riboflavin attractive as a safe and inexpensive drug for treating malaria caused by P. falciparum.
Safety and efficacy of the multidrug-resistance inhibitor biricodar (VX-710) with concurrent doxorubicin in patients with anthracycline-resistant advanced soft tissue sarcoma.

PURPOSE Incel (biricodar, VX-710) restores drug sensitivity to P-glycoprotein and multidrug resistance-associated protein-1-expressing cells. This Phase I/II study evaluated the safety/tolerability, pharmacokinetics, and efficacy of VX-710 plus doxorubicin in patients with inoperable, locally advanced or metastatic, anthracycline-resistant/refractory, soft tissue sarcoma. EXPERIMENTAL DESIGN In Phase I, i.v. bolus doxorubicin at 60, 75, or 67.5 mg/m(2) was administered 8 h after initiation of a 72-h continuous i.v. (CIV) infusion of VX-710 (120 mg/m(2)/h) to cohorts of patients to establish a maximum tolerated dose. For efficacy evaluations in Phase II, eligible patients had inoperable, locally advanced or metastatic, anthracycline-resistant/refractory soft tissue sarcoma; < or =225 mg/m(2) cumulative prior doxorubicin; and adequate hematological, liver, and kidney function. Cycles were repeated every 3 weeks. RESULTS Fourteen patients were enrolled in Phase I. Myelosuppression was the dose-limiting toxicity with 75 and then 67.5 mg/m(2) doxorubicin, and the maximum tolerated dose was established at 60 mg/m(2) with VX-710, 120 mg/m(2)/h, 72-h CIV. VX-710 had no apparent effect on doxorubicin pharmacokinetics. Twenty-nine patients enrolled in Phase II were treated with VX-710, 120 mg/m(2)/h 72-h CIV, and 60 mg/m(2) doxorubicin. Among 26 evaluable patients, minimal activity was noted among 11 patients with gastrointestinal stromal tumors (GISTs); however, in 15 patients with anthracycline-resistant sarcomas of other histologies, 2 achieved partial responses and 7 patients had disease stabilization with an overall median progression-free interval of 3.4 months. CONCLUSION Anthracycline resistance in GISTs appears to be independent of P-glycoprotein or multidrug resistance-associated protein-1 resistance mechanisms. However, the combination of VX-710 and doxorubicin resulted in objective responses or disease stabilization in patients with strictly defined anthracycline-refractory non-GIST sarcomas, which warrants further evaluation.
Keck Infrared Observations of Jupiter's Ring System

Abstract We imaged the jovian ring system at a wavelength of 2.27 μm with the 10-m W. M. Keck telescope on August 14 and 15, 1997, when the ring plane was almost edge-on (opening angle β=0.17°) and near opposition (phase angle α≈1.1°). The resolution in the images is 0.6″=0.025 R J . We obtained the first images of the jovian halo and gossamer ring in back-scattered light, and the best ground-based images to date of Jupiter's main ring. The main ring is radially confined between 1.70 and 1.82 R J (where 1 R J =71398 km), with a maximum (after inversion) at 1.79 R J , in agreement with the Voyager findings. The halo extends inward from the main ring (at 1.71 R J ) down to 1.40 R J , apparently bounded by the locations of Lorentz resonances. Roughly 50% of the halo's intensity originates from a region within ∼700 km from the equatorial plane, although it is visible up to ∼10,000 km above and below the plane. Although the vertical extent agrees with Voyager findings, the halo's intensity relative to that of the main ring in the Keck images is much less than in forward-scattered Voyager images, which we attribute to a predominance of micrometer-sized particles, which scatter visible light preferentially in the forward direction. The gossamer ring is found to have two components, with steep dropoffs in brightness at the orbits of Amalthea and Thebe. The first, Amalthea's gossamer ring, is visible between the main ring's periphery and ∼2.55 R J ; it is relatively uniform in brightness and has a vertical thickness (FWHM) of 0.06 R J , clearly broader than the FWHM of the main ring (0.045 R J ) and the image resolution. The other component, Thebe's gossamer ring, is a factor of five fainter than Amalthea's ring and about twice as broad vertically (FWHM≈0.12 R J ). This ring extends outward to 3.11 R J , but additional material is visible, albeit barely, out to ∼3.6 R J , near the edge of our images. The vertical extent of both the Thebe and Amalthea rings decreases with decreasing distance to the planet.
Interleukin 12 in host defense against microbial pathogens.

Interest in microbial pathogenesis has increasingly focused on the interactions of organisms with the innate immune system. Several investigators using different systems have demonstrated the critical role played by cytokines released during the initial contact of pathogens with host macrophages in shaping the subsequent cognate immune response orchestrated by T cells. Recent commentaries have called attention to these developments (1, 2), but two manuscripts (3, 4) appearing in these Proceedings within the past few months have prompted consideration of the role of a relatively recently described cytokine, interleukin 12 (IL-12), in this response. A number of intracellular pathogens have been shown to induce T-cell re-
Study of Oral Acute Toxicity/Pathogenicity of the Tsukamurella paurometabola Active Agent of the Biological Nematicide C-924 (Hebernem®)

The nematodes constitute one of the most phyto-pathogenic species in agriculture, using chemical and biological control agents. The Tsukamurella paurometabola is a bacterial strain with possibilities of being used as a nematicide; thus, it is necessary to evaluate the effect of its administration in lab animals with the objective of estimating its toxicity, infectivity and pathogenicity. To accomplish this aim, it was administered a single dose of 108 ufc/animal with T. paurometabola C-924 in three variants as an active agent, final product (HEBERNEM®) and inactive final product by oral route to Sprague-Dawley rats of both sexes, and their respective placebos. The analyzed variables were: clinical observation, feed and water consumption, body weight, infectivity (tissues, organs and biological fluids), clearing or persistence (faeces collection) and gross and microscopic evaluations of interest organs. The obtained results showed that the administration of this microorganism in their three variants and their placebos, under our experimental conditions, didn’t cause lethality neither influenced on weight, behavior and the physical state in the experimentation animals. The persistence showed that the microorganism was totally eliminated towards the day 15 of the study; likewise the infectivity determinations demonstrated the non-existence of colony formed units of the T. paurometabola in different times of samplings, resulting its inability to invade the guest’s natural barriers, to infect it or to cause pathogenicity. The administration of the T. paurometabola, as an active agent and as final product, didn’t cause signs, infective or pathogenic or toxic reactions in the experimentation animals.
Sociodemographic and geographic correlates of meeting current recommendations for physical activity in middle-aged French adults: the Supplémentation en Vitamines et Minéraux Antioxydants (SUVIMAX) Study.

OBJECTIVE We evaluated the characteristics of French subjects meeting current public health recommendations for physical activity. METHODS We assessed leisure-time physical activity cross-sectionally in 7404 adults aged 45 to 68 years with applied logistic regression models. RESULTS Meeting the recommended physical activity levels was more likely in subjects aged 60 years and older and in women with higher education levels or living in rural areas and was less likely in smokers. No association was found with time spent watching television. The contribution of vigorous activity to total time spent being active was approximately 2 times higher in subjects meeting recommendations. CONCLUSIONS Participation in some vigorous activity may be viewed as a "facilitator" to attain physical activity recommendations. Relationships with physical environment variables in Europe need further investigation.
Evaluating Augmented Reality Applications in Construction - a Cost-Benefit Assessment Framework based on VOFI

Industry 4.0 application scenarios, based on the use of Augmented Reality (AR) in combination with wearable devices like Smart Glasses or Head-Mounted Displays (HMD), offer construction companies several opportunities to better deal with the complexity of the construction environment. Despite the given maturity of AR technology, tools or methods to estimate the costs and benefits associated with its adoption have not been provided to date. In general, high implementation costs and unclear benefits of this technology are considered as barriers to its widespread adoption. Therefore, the primary aim of this paper is to develop an assessment framework for evaluating costs and benefits of information systems (IS) investments based on an AR-based application scenario in the construction domain. By the same token, we intend to demonstrate how a traditional cost-benefit analysis (CBA) can be applied more effectively to assist in the decision-making process. The assessment framework is developed by means of a systematic literature review and evaluated by means of expert interviews as well as a simulation using the appraisal method Visualisation of Financial Implications (VoFI). Additionally, risk considerations are made by conducting a sensitivity analysis and a probability risk analysis.
Evidence for Impaired Encoding and Retrieval Memory Profiles in Parkinson Disease

Objective: The purpose of the study was to determine whether patients with Parkinson disease (PD) demonstrate different memory profiles. Specifically, we sought to ascertain whether the memory performance of PD patients can be categorized as fitting an unimpaired, an impaired retrieval, or an impaired encoding memory profile. Background: Cognitive impairment in PD is usually described as subcortical-frontal in nature. However, neuropathophysiological changes consistent with diffuse cortical disease are also reported. Establishing memory subtypes in PD could potentially assist in reducing the observed heterogeneity of disease presentation, establishing prognosis, making clinical decisions, and defining endpoints in clinical trials. Methods: A sample of 63 PD patients was evaluated with the Hopkins Verbal Learning Test-Revised (HVLT-R). Cluster analysis was used to classify patients into three memory subgroups based on performance on free recall, intrusion errors, and recall enhancement with recognition. Subgroup comparisons were made for demographic and clinical characteristics. Results: An "unimpaired" group (n = 30) demonstrated intact free recall and few intrusion errors. "Impaired retrieval" (n = 22) and "impaired encoding" (n = 11) subgroups with similar impairment on free recall were also identified, but the impaired retrieval group demonstrated greater memory improvement with recognition (P < 0.001) and had fewer intrusion errors (P < 0.001) than the impaired encoding group. Conclusions: A majority of PD patients demonstrate memory impairment, which can be categorized as either a primary retrieval or a primary encoding deficit. Further research is needed to confirm memory subtypes in PD and determine their diagnostic, prognostic, and therapeutic significance.
Action of Penicillin on Bacterial Utilization of Amino Acids and Peptides.

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