Miracle-dz/UniFAR-FTUs huggingface dataset:
Determination of Tear and Serum Inflammatory Cytokines in Patients with Rosacea Using Multiplex Bead Technology

Abstract Purpose: To compare serum and tear inflammatory and anti-inflammatory cytokine levels of rosacea patients with the healthy controls and evaluate the correlation of tear cytokine levels with tear function parameters. Methods: Tear and serum interleukin (IL)-1α, IL-6, IL-8, IL-10, monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein-1α (MIP-1α), epidermal growth factor (EGF), and vascular endothelial growth factor (VEGF) levels were measured using multiplex bead (Luminex) technology in 12 rosacea patients without ocular involvement (group 1), 20 rosacea patients with ocular involvement (group 2), and 22 healthy subjects (group 3). The correlation of the cytokines with tear function parameters was analyzed using Spearman correlation test. Results: Tear IL-10 and VEGF levels were significantly lower in group 1 (median: 35.78 pg/mL and 427.29, respectively) and group 2 (median: 26.25 pg/mL and 348.31, respectively) than in group 3 (median: 75.96 pg/mL and 480.12, respectively) (p < 0.05). Mean serum IL-8 level was significantly lower in group 2 (median = 0) compared to group 3 (median = 3.98) (p = 0.02). Tear breakup time was found to be positively correlated with IL-10 (r = 0.46, p = 0.013) and inversely correlated with MCP-1 (r = −0.52, p = 0.004). Conclusions: Tear and serum levels of cytokines and growth factors measured with Luminex technology showed a large variation in rosacea and healthy subjects. Decreased levels of tear IL-10, an anti-inflammatory cytokine, may lead to an inflammatory ocular surface environment, exacerbate ocular surface inflammation, and deteriorate tear function tests. A bigger sample size, including rosacea patients with corneal involvement, is needed to confirm the role of cytokines in the pathogenesis of rosacea-associated ocular inflammation.
Learning text patterns to detect opinion targets

Exploiting sentiment relations to capture opinion targets has recently caught the interest of many researchers. In many cases target entities are themselves part of the sentiment lexicon creating a loop from which it is difficult to infer the overall sentiment to the target entities. In the present work we propose to detect opinion targets by extracting syntactic patterns from short-texts. Experiments show that our method was able to successfully extract 1,879 opinion targets from a total of 2,052 opinion targets. Furthermore, the proposed method obtains comparable results to SemEval 2015 opinion target models in which we observed the syntactic structure relation that exists between sentiment words and their target.
Prevalence and Correlates of Missed First Appointments among Outpatients at a Psychiatric Hospital in Nigeria

Background: Missed appointments are common in psychiatric practice. It compromises quality of care, results in poor treatment outcomes and drains financial resources. In Nigeria, where mental health services are poorly organized, missed appointments and its resultant consequences may be burdensome. Aim: This study sought to determine the prevalence and factors (sociodemographic and clinical) associated with missed clinic appointments at a regional psychiatric hospital. Subjects and Methods: A study on a cohort of patients attending the Outpatient Clinics for the first time between June and September 2011 was conducted. We interviewed each participant at their first presentation then tracked through case records to determine adherence to scheduled first clinic appointments after 4 weeks. A questionnaire was used in eliciting sociodemographic characteristics, clinical variables, and patient/caregiver satisfaction with treatment. Descriptive statistics were used to summarize the data and inferential statistics to test associations using the SPSS 16. Results: Three hundred and ten patients were recruited over the study period. The prevalence of missed first appointment was 32.6% (101/310). Participants who were single (P = 0.04), living alone (P < 0.01) or aggressive (P < 0.01) were more likely to miss their first appointment. However, having received previous treatment for a psychiatric illness (P = 0.02) and having comorbidity (P = 0.05) was associated with less likelihood to miss a first appointment. A binary logistic regression analysis showed that having received previous treatment independently predicted a less likelihood to miss first appointment (P = 0.03). Conclusion: Quite a proportion (32.6%) of patients attending outpatient clinics miss scheduled clinic appointments. Receiving previous psychiatric care predicted adherence to scheduled appointment.
Early Detection of Acute Rhinovirus Infections by a Rapid Reverse Transcription-PCR Assay

ABSTRACT The development of a rhinovirus (RV)-RNA-specific reverse transcription (RT)-PCR assay is complicated by the close homology between the RV and enterovirus (EV) genomes in the highly conserved 5′-noncoding region, which is chosen for primer design in most RT-PCR assays. We have developed a sensitive, rapid, and RV-specific nested RT-PCR assay and have used it to test nasopharyngeal aspirates from 556 patients presenting with acute respiratory tract infections. RV RNA was detected by nested RT-PCR not only in all of 52 samples that were RV positive by virus isolation methods but also in 124 of 367 samples that were negative by virus isolation methods and enzyme-linked immunosorbent assay (ELISA). In addition, in 23 of 137 samples that were positive for a different respiratory virus by virus isolation and/or ELISA, RV RNA was detected by RT-PCR. EVs, adenoviruses, respiratory syncytial viruses, coronaviruses, and influenza and parainfluenza viruses, including clinical isolates as well as stock viruses, were not amplified in our RV-specific RT-PCR assay, indicating that this assay was highly specific. The processing time was less than 2 days for the RT-PCR, as opposed to up to 2 weeks for virus isolation. These results indicate that nested RT-PCR is more sensitive than conventional methods for the detection of RV in patients experiencing acute respiratory tract infections and represents the only reliable tool for the early laboratory diagnosis of RV infections. This is especially important in light of new opportunities for therapy currently being developed.
The merit factor of Legendre sequences

Turyn has shown by numerical computation that the merit factor of long Legendre sequences offset by a quarter of their length has in all likelihood the asymptotic value 6 . The ergodicity postulate is used in this correspondence to calculate that the merit factor F of a Legendre sequence offset by a fraction f of its length has an asymptotic value given by 1/F=(2/3)-4|f|+8f^{2}, |f|\leq 1/2 , which gives F=6 for |f|=1/4 .
Effective stateless model checking for C/C++ concurrency

We present a stateless model checking algorithm for verifying concurrent programs running under RC11, a repaired version of the C/C++11 memory model without dependency cycles. Unlike most previous approaches, which enumerate thread interleavings up to some partial order reduction improvements, our approach works directly on execution graphs and (in the absence of RMW instructions and SC atomics) avoids redundant exploration by construction. We have implemented a model checker, called RCMC, based on this approach and applied it to a number of challenging concurrent programs. Our experiments confirm that RCMC is significantly faster, scales better than other model checking tools, and is also more resilient to small changes in the benchmarks.
Cytogenetic abnormalities in myelodysplastic syndrome: an overview

Abstract The myelodysplastic syndromes (MDS) are clonal disorders of haematopoietic stem cells characterized by ineffective haematopoiesis leading to blood cytopenias and by high incidence of progression to acute myeloid leukaemia (AML). These disorders generally arise de novo, but may also occur years after exposure to mutagenic chemotherapy. Clonal cytogenetic abnormalities are detected in about 30–50% de novo cases, whereas more than 80% of therapy-related forms harbour such markers. Although in the Western countries, MDS cases are mainly reported in the elderly population and rarely in the paediatric age group; this disease is increasingly seen in young adults in India. Cytogenetic study plays an important role in the diagnosis and is useful for prediction of individual prognosis using the international prognostic scoring system. Specific chromosomal abnormalities, such as −5/5q-, −7/7q-, and complex abnormalities, play an important role in the development of new therapeutic options and clinical management of MDS. In this review, we summarize the cytogenetic abnormalities in MDS from various parts of the world.
Observation of an oxygen isotope effect in superconducting (Y1-xPrx)Ba2Cu3O7- delta.

The oxygen isotope effect was studied in the system (Y{sub 1{minus}{ital x}}Pr{sub {ital x}})Ba{sub 2}Cu{sub 3}O{sub 7{minus}{delta}} for {ital x}=0.2, 0.3, 0.4, and 0.5. It is found that the oxygen isotope exponent {alpha} increases with increasing {ital x} and therefore decreasing transition temperature {ital T}{sub {ital c}}. For the highest Pr concentrations {alpha} tends toward {alpha}=0.5. The value of the isotope exponent depends on the concentration of mobile holes. The lower this concentration is, the larger becomes the isotope exponent.
Spatial Concentration of the Informal Small and Cottage Industry in Indonesia

This paper discusses the spatial concentration of the small and cottage industry without legal entity in Indonesia. The study period is 1998-2004 or a period after economic crisis which commonly known as the ‘era reformasi’ (reformation era). By employing the Herfindahl index, this study found an increase in the spatial concentration of the informal small and cottage industry during this period. It argues that reformation tend to increase the spatial concentration of the informal small and cottage industry. Beside the economic crisis that have suffered urban and Java areas, other possible explanation on the connection between trend of the concentration and the reformation is what commonly known as the cost of formality.
Mon2 is a negative regulator of the monomeric G protein, Arl1.

Using site-directed mutants of ARL1 predicted to alter nucleotide binding, we examined phenotypes associated with the loss of ARL1 , including effects on membrane traffic and K (+) homeostasis. The GTP-restricted allele, ARL[Q72L] , complemented the membrane traffic phenotype (CPY secretion), but not the K (+) homeostasis phenotypes (sensitivity to hygromycin B, steady-state levels of K (+) , and accumulation of (86) Rb (+) ), while the XTP-restricted mutant, ARL1[D130N] , complemented the ion phenotypes, but not the membrane traffic phenotype. A GDP-restricted allele, ARL1[T32N] , did not effectively complement either phenotype. These results are consistent with a model in which Arl1 has three different conformations in vivo. We also explored the relationship between ARL1 and MON2 using the synthetic lethal phenotype exhibited by these two genes and demonstrated that MON2 is a negative regulator of the GTP-restricted allele of ARL1 , ARL1[Q72L] . Finally, we constructed several new alleles predicted to alter binding of Arl1 to the sole GRIP domain containing protein in yeast, Imh1, and found that ARL1[F52G] and ARL1[Y82G] were unable to complement the loss of ARL1 with respect to either the membrane traffic or K (+) homeostasis phenotypes. Our study expands understanding of the roles of Arl1 in vivo.
H6 Transformerless Full-Bridge PV Grid-Tied Inverters

Transformerless inverters are widely used in grid-tied photovoltaic (PV) generation systems, due to the benefits of achieving high efficiency and low cost. Various transformerless inverter topologies have been proposed to meet the safety requirement of leakage currents, such as specified in the VDE-4105 standard. In this paper, a family of H6 transformerless inverter topologies with low leakage currents is proposed, and the intrinsic relationship between H5 topology, highly efficient and reliable inverter concept (HERIC) topology, and the proposed H6 topology has been discussed as well. One of the proposed H6 inverter topologies is taken as an example for detail analysis with operation modes and modulation strategy. The power losses and power device costs are compared among the H5, the HERIC, and the proposed H6 topologies. A universal prototype is built for these three topologies mentioned for evaluating their performances in terms of power efficiency and leakage currents characteristics. Experimental results show that the proposed H6 topology and the HERIC achieve similar performance in leakage currents, which is slightly worse than that of the H5 topology, but it features higher efficiency than that of H5 topology.
In-vitro comparison of fondaparinux, unfractionated heparin, and enoxaparin in preventing cardiac catheter-associated thrombus

BackgroundThe Organization to Assess Strategies in Acute Ischemic Syndromes trials showed that fondaparinux (fonda) is at least as effective and safe as unfractionated heparin (UFH) and enoxaparin (enoxa) in acute coronary syndromes. Unexpectedly, there was an increase in catheter-related thrombus formation during percutaneous coronary interventions in fonda-treated patients. MethodsTen healthy male volunteers were pretreated with aspirin 500 mg 2 h before venesection of 50 ml of blood. Eight groups of anticoagulant (combinations) were tested and volunteers donated blood eight times, thus, acting as their own controls. The groups were UFH, UFH+eptifibatide, enoxa, enoxa+eptifibatide, fonda, fonda+eptifibatide, fonda+(half-therapeutic) UFH, and fonda+eptifibatide+(half-therapeutic) UFH. The blood/anticoagulant mix was kept at 37°C and continuously circulated through a guiding catheter for 60 min or until the catheter became blocked with thrombus. Thrombus development was assessed by weighing each catheter before and after the procedure. Electron microscopy of the catheter lining was used to quantify the degree of erythrocyte and fibrin deposition. ResultsDespite fonda anticoagulation, catheters were invariably occluded by thrombus before the 60 min perfusion period had elapsed. Thrombotic catheter occlusion occurred even with higher fonda concentrations and combined fonda/eptifibatide use. All other combinations (including fonda and half-therapeutic UFH) ensured catheter patency for 60 min. Furthermore, thrombus weight and the cell/fibrinogen counts were significantly increased in fonda and fonda+eptifibatide compared with other treatment groups. ConclusionTreatment with fonda, even in combination with eptifibatide, was not sufficient to prevent cardiac catheter thrombus development in our in-vitro study. However, the combination of fonda with ‘half’ therapeutic dosages of UFH were as efficient as other treatment strategies in preventing thrombus formation.
Interactions with titin and myomesin target obscurin and obscurin-like 1 to the M-band – implications for hereditary myopathies

Obscurin, a giant modular muscle protein implicated in G-protein and protein-kinase signalling, can localize to both sarcomeric Z-disks and M-bands. Interaction of obscurin with the Z-disk is mediated by Z-disk titin. Here, we unravel the molecular basis for the unusual localization of obscurin, a Z-disk-associated protein, to the M-band, where its invertebrate analogue UNC-89 is also localized. The first three domains of the N-terminus of obscurin bind to the most C-terminal domain of M-band titin, as well as to the M-band protein myomesin. Both proteins also interact with the N-terminal domains of obscurin-like 1 (Obsl1), a small homologue of obscurin. Downregulation of myomesin by siRNA interference disrupts obscurin–M-band integration in neonatal cardiomyocytes, as does overexpression of the binding sites on either myomesin, obscurin or Obsl1. Furthermore, all titin mutations that have been linked to limb-girdle muscular dystrophy 2J (LGMD2J) or Salih myopathy weaken or abrogate titin-obscurin and titin-Obsl1 binding, and lead to obscurin mislocalization, suggesting that interference with the interaction of these proteins might be of pathogenic relevance for human disease.
Development of a data-based short food frequency questionnaire for assessing nutrient intake by middle-aged Japanese.

OBJECTIVE Development of a data-based short food frequency questionnaire (FFQ) for evaluating intake of nutrients by middle-aged Japanese. METHODS Of 102 foods listed in the formerly developed semi-quantitative FFQ, foods having similar nutrient contents were combined into 72 foods/food groups by research dietitians. Nutrient contents were computed by multiplying the weight of foods consumed and its nutrient contents. Next, a cumulative multiple regression coefficient up to 0.85 was applied, and 47 foods/food groups were chosen for a brief FFQ for assessing intake of 21 nutrients including energy, protein, fat, carbohydrate, vitamins, minerals, and dietary fibers. RESULTS The 47 foods/food groups comprised rice, bread and noodles (3), margarine/butter (2), eggs (1), milk and dairy products (2), soybean and soybean products (3), miso-soup (1), meat including beef, pork and chicken (4), fish (3), other fish, shellfish and fish products (4), green-yellow vegetables (5), other vegetables and mushrooms (3), edible roots (4), seaweeds (1), mayonnaise (1), fried dishes (2), seeds (1), fruit (2), beverages, including alcohol (3), and confectioneries (2). CONCLUSIONS The evidence-based short FFQ efficiently covered the intake of 21 nutrients, and may be competent to rank the middle-aged general public Japanese according to intake of nutrients.
Sociolinguistic and Contact-induced Variation in Hungarian Language Use in Subcarpathia, Ukraine

In addition to showing regional and social variation, the language use of the minority Hungarians of Subcarpathia, Ukraine, also presents a reflection of the region’s complex linguistic history and its effects from contact with Russian and Ukrainian. On the basis of quantitative empirical findings, this study shows Subcarpathian Hungarians to be a sociolinguistically stratified group of speakers whose Hungarian language use varies in a systematic manner according to sex, age, level of education, and place of residence. The paper also outlines some of the main differences in the language use of Hungarians in Subcarpathia and Hungary which are manifested in statistically significant ways.
Diffusion in simple fluids

Computed self diffusion coefficients for the Lennard-Jones and hard sphere fluids are related by where σB=σLJ(2/[1+ⅈ(1+2k B T/e)])1/6, the effective hard sphere diameter, is the (average) distance of closest approach in collisions between molecules which interact with the positive part of the LJ potential, and the Arrhenius term reflects the influence of the negative part. σLJ and ϵ are the size and well depth parameters. Measured diffusion coefficients of the halomethane liquids are reproduced by the equation over wide ranges of temperature and density and do not reveal any influence of the inelastic effects associated with molecular anisotropy.
SMALL AND UGLY? PHYLOGENETIC ANALYSES OF THE “SELFING SYNDROME” REVEAL COMPLEX EVOLUTIONARY FATES OF MONOMORPHIC PRIMROSE FLOWERS

One of the most common trends in plant evolution, loss of self‐incompatibility and ensuing increases in selfing, is generally assumed to be associated with a suite of phenotypic changes, notably a reduction of floral size, termed the selfing syndrome. We investigate whether floral morphological traits indeed decrease in a deterministic fashion after losses of self‐incompatibility, as traditionally expected, using a phylogeny of 124 primrose species containing nine independent transitions from heterostyly (heteromorphic incompatibility) to homostyly (monomorphic self‐compatibility), a classic system for evolution of selfing. We find similar overall variability of homostylous and heterostylous species, except for diminished herkogamy in homostyles. Bayesian mixed models demonstrate differences between homostylous and heterostylous species in all traits, but net effects across species are small (except herkogamy) and directionality differs among traits. Strongly drift‐like evolutionary trajectories of corolla tube length and corolla diameter inferred by Ornstein–Uhlenbeck models contrast with expected deterministic trajectories toward small floral size. Lineage‐specific population genetic effects associated with evolution of selfing may explain that reductions of floral size represent one of several possible outcomes of floral evolution after loss of heterostyly in primroses. Contrary to the traditional paradigm, selfing syndromes may, but do not necessarily evolve in response to increased selfing.
The influence of golf club shaft stiffness on clubhead kinematics at ball impact

The role of shaft stiffness on the golf swing is not well understood. Studies in which golfers hit balls with clubs of varying shaft flex have reported changes in ball distance. The results of mathematical models suggest that shaft stiffness affects only the orientation of the clubhead at impact, not the speed of the clubhead, but there are no experimental results validating these findings. The purpose of this study was therefore to experimentally examine the influence of shaft stiffness on clubhead kinematics at ball impact. Forty golfers hit 10 balls with each of five drivers varying in shaft stiffness from ‘Ladies’ to ‘Extra-Stiff,’ in a double-blind study design. The motions of three reflective markers attached to the clubhead were captured with a high-speed motion analysis system. At ball impact, shaft stiffness had a statistically significant influence on clubhead speed for 27 subjects, on loft angle for 11 subjects, and on lie angle for all 40 subjects. No effect was observed on face angle, in to out path angle, or attack angle. These results show that shaft stiffness can affect ball launch conditions by altering clubhead speed and/or loft angle.
Characteristics of prisoners with intellectual disabilities

BACKGROUND Previous studies have found high rates of intellectual disabilities (ID) in prison. However, little is understood about prisoners with ID. This study aimed to identify prisoners with ID and compare their characteristics with prisoners without neurodevelopmental disorders with regard to demographic profile, mental health, suicide risk and offences. METHOD This was a descriptive, cross-sectional study carried out using face-to-face interviews with 240 participants in a London Category C prison. Standardised tools were used to assess prisoners for ID and mental disorder. RESULTS The study identified 18 prisoners as having ID. Participants with ID were less likely to be from a black or minority ethnic background, be over 35 years of age or have any qualifications. They were more likely to have been single, homeless or unemployed before coming into prison. Prisoners with ID were significantly more likely to have mental health problems and 25% had thought about suicide in the last month and 63% had attempted suicide in the past. Prisoners with ID were also more likely to be housed in the vulnerable prisoners' wing and significantly more likely to have committed robbery than other prisoners. CONCLUSIONS The findings confirm the presence of significant numbers of people with ID with high levels of mental illness in a male prison. Services across the CJS are required for this group, specifically, there is a need for raised awareness among those working in prison about ID and improved skills to recognise offenders with ID and address major gaps in current healthcare provision in prison.