Miracle-dz/UniFAR-FTUs huggingface dataset:
Complete or ultraconservative removal of decayed tissue in unfilled teeth.

BACKGROUND The treatment of deep dental decay has traditionally involved removal of all the soft demineralised dentine before a filling is placed. However this has been challenged in three groups of studies which involve sealing soft caries into the tooth. The three main groups either remove no caries and seal the decay into the tooth, remove minimal (ultraconservative) caries at the entrance to a cavity and seal the remaining caries in, or remove caries in stages over two visits some months apart to allow the pulp time to lay down reparative dentine (the stepwise excavation technique). OBJECTIVES To test the null hypothesis of no difference in the incidence of damage or disease of the nerve of the tooth (pulp), progression of decay and longevity of restorations irrespective of whether the removal of decay had been minimal (ultraconservative) or complete. SEARCH STRATEGY The Cochrane Oral Health Group Trials Register, Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, PubMed and EMBASE databases were searched. The reference lists in relevant papers were checked. SELECTION CRITERIA Randomised controlled trials and controlled clinical trials comparing minimal (ultraconservative) caries removal with complete caries removal in unrestored permanent and deciduous teeth. DATA COLLECTION AND ANALYSIS Outcome measures recorded were exposure of the nerve of the tooth (pulp) during caries removal, patient experience of symptoms of pulpal inflammation or necrosis, progression of caries under the filling, time until the filling was lost or replaced. Due to the heterogeneity of the included studies the overall estimate of effect was calculated using a random-effects model. MAIN RESULTS Four studies met the inclusion criteria; two stepwise excavation studies and two ultraconservative caries removal studies. Partial caries removal in symptomless, primary or permanent teeth reduces the risk of pulp exposure. We found no detriment to the patient in terms of pulpal symptoms in this procedure and no reported premature loss or deterioration of the restoration. AUTHORS' CONCLUSIONS The results of this systematic review reject the null hypothesis of no difference in the incidence of damage or disease of the nerve of the tooth (pulp) irrespective of whether the removal of decay had been minimal (ultraconservative) or complete and accepts the null hypothesis of no difference in the progression of decay and longevity of restorations. However, the number of included studies is small and differ considerably. Partial caries removal is therefore preferable to complete caries removal in the deep lesion, in order to reduce the risk of carious exposure. However, there is insufficient evidence to know whether it is necessary to re-enter and excavate further but studies that have not re-entered do not report adverse consequences.
The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development

Background: During development, the homeobox gene Cdx2 exerts a homeotic function, providing the positional information necessary for correct specification of the midgut endoderm. This is illustrated by the non-neoplastic gastric-type heteroplasias present at birth in the pericaecal region of Cdx2+/− mice. Furthermore, intestinal expression of Cdx2 continues throughout life but diminishes in colorectal cancers compared with adjacent normal tissue, suggesting a role in tumorigenesis. Aim: To investigate the consequence of altered Cdx2 expression on colon tumour initiation and/or progression. Methods: Heterozygous Cdx2+/− mice were analysed for spontaneous malignant tumours and for tumour development after treatment with a DNA mutagen, azoxymethane. Results:Cdx2+/− mice did not spontaneously develop malignant tumours. After azoxymethane treatment, the gastric-like heteroplasias in the pericaecal region did not evolve into cancer indicating that they are not precancerous lesions. However, azoxymethane treated Cdx2+/− mice developed tumours specifically in the distal colon 12 weeks after azoxymethane treatment whereas no tumours were found in wild-type littermates at this stage. Histopathological and molecular analyses indicated that these tumours were invasive adenocarcinomas that recapitulated the malignant sequence observed in the majority of sporadic colorectal cancers in human. In addition, we found that the colonic epithelium was less sensitive to radiation induced apoptosis in Cdx2+/− than in wild-type mice. Conclusion: This study provides the first experimental evidence that Cdx2 is a tumour suppressor gene involved in cancer progression in the distal colon. This action in adults is functionally and geographically distinct from its homeotic role during gut development.
Neonatal hypothyroidism causes delayed sertoli cell maturation in rats treated with propylthiouracil: Evidence that the sertoli cell controls testis growth

Background: The testes of rats treated neonatally with propylthiouracil (PTU) grow to almost twice their normal size. The cause of testicular enlargement has been suggested to be the result of delayed maturation of Sertoli cells, allowing Sertoli cell division to occur beyond the 15th postnatal day, the commonly recognized cutoff date for Sertoli cell divisions. It has been shown that an increased population of Sertoli cells in postnatal development supports increased numbers of germ cells in adult animals. After examining developing rats treated neonatally with PTU, we hypothesized that an approximate 10‐day delay in maturation was occurring and proceeded to test this hypothesis experimentally. Thus the purpose of this report was to determine if a 10‐day delay in maturation could explain the increased numbers of Sertoli cells and increased testis size in PTU‐treated animals.
Categorization of somaesthetic stimuli: sensorimotor performance and neuronal activity in primary somatic sensory cortex of awake monkeys.

We used psychometric techniques to study the sensorimotor performance of four monkeys trained to classify the speed of moving tactile stimuli. Animals performed the task by pressing one of two target switches to indicate whether the speed of probe movement across the glabrous skin of the hand was low or high. Psychometric curves indicated that animals classified the stimulus speeds irrespective of which finger was stimulated, traverse distance and direction. The mean values of the reaction (RT) and movement (MT) times during the correct categorization of low and high stimulus speeds were similar. However, a slight increase was detected in the mean values of the RT during the incorrect categorization but not in the MT. During the task, activity of single neurones (n = 45) was recorded in primary somatic sensory (SI) cortex. The results indicate that a class of neurones (n = 12) of SI cortex increased their impulse rates as a function of the stimulus speeds. However, the magnitude of their responses was similar during the correct and incorrect categorizations of stimuli. The same neurones also responded when the same set of stimuli used in the categorization task were delivered passively. Neurones of SI cortex responded with a latency of 25.8 +/- 0.6 ms (+/- s.e.m.) relative to the beginning of the moving tactile stimuli during the categorization task. The same neurones (n = 17) also responded with a similar latency (24.6 +/- 4.0 ms) when the stimuli were delivered passively. These results may suggest that, although this evoked neuronal activity may be important for the perception of the moving tactile stimuli, more central structures associated with SI cortex may determine the performance of this learned somaesthetic task.
Echocardiographic Evaluation of Patent Foramen Ovale and Atrial Septal Defect

Patent foramen ovale (PFO) is a common variant present in up to 25% of the population. Atrial septal defect (ASD) is a direct communication between the 2 atrial chambers, of which the ostium secundum variety is the most common. This manuscript is an in depth review of the complex atrial septation, the diagnosis of PFO and ASD and its clinical and therapeutic implications.
Dynamic Monte Carlo study of isolated-gate InAs/AlSb HEMTs

In this work, by means of Monte Carlo simulations, the static and dynamic behavior of isolated-gate InAs/AlSb high electron mobility transistors (Sb-HEMTs) has been studied and compared with experimental results. The influence of the existence of a native oxide under the gate, the value of the surface charges in the gate recess and the possible variation of electron sheet carrier density, ns, have been studied. A decrease in the gate-source capacitance, transconductance and intrinsic cutoff frequency is observed because of the presence of the native oxide, while changes in the value of the surface charges in the recess only introduce a threshold voltage shift. The increase of ns shifts the maximum of the transconductance and intrinsic cutoff frequency to higher values of drain current and improves the agreement with the experimental results.
Influence of Physical Activity in Different Age and Life Periods on the Risk of Breast Cancer

We conducted a population-based case-control study of 1,237 incident breast cancer cases and 1,241 controls in Alberta between 1995 and 1997 to examine the effect of physical activity performed at different ages and life periods on breast cancer risk. In this study, we measured all types of physical activity done throughout life with a questionnaire developed and tested specifically for this study. We found that breast cancer risk was most associated with a risk reduction for activity done later in life, particularly between menopause and the reference year, for which we observed an odds ratio of 0.70 (95% confidence interval = 0.52–0.95). We also stratified the study participants into four categories according to their patterns of physical activity performed before and after menopause. For the women who sustained physical activity throughout life vs those who were never active, we found an odds ratio of 0.58 (95% confidence interval = 0.41–0.83). This study suggests that sustained activity throughout life and particularly activity done later in life may have the most benefit in reducing breast cancer risk.
Mechanisms Affecting Population Density in Fragmented Habitat

We conducted a factorial simulation experiment to analyze the relative importance of movement pattern, boundary-crossing probability, and mortality in habitat and matrix on population density, and its dependency on habitat fragmentation, as well as inter-patch distance. We also examined how the initial response of a species to a fragmentation event may affect our observations of population density in post-fragmentation experiments. We found that the boundary-crossing probability from habitat to matrix, which partly determines the emigration rate, is the most important determinant for population density within habitat patches. The probability of crossing a boundary from matrix to habitat had a weaker, but positive, effect on population density. Movement behavior in habitat had a stronger effect on population density than movement behavior in matrix. Habitat fragmentation and inter-patch distance may have a positive or negative effect on population density. The direction of both effects depends on two factors. First, when the boundary-crossing probability from habitat to matrix is high, population density may decline with increasing habitat fragmentation. Conversely, for species with a high matrix-to-habitat boundary-crossing probability, population density may increase with increasing habitat fragmentation. Second, the initial distribution of individuals across the landscape: we found that habitat fragmentation and inter-patch distance were positively correlated with population density when individuals were distributed across matrix and habitat at the beginning of our simulation experiments. The direction of these relationships changed to negative when individuals were initially distributed across habitat only. Our findings imply that the speed of the initial response of organisms to habitat fragmentation events may determine the direction of observed relationships between habitat fragmentation and population density. The time scale of post-fragmentation studies must, therefore, be adjusted to match the pace of post-fragmentation movement responses.
A Pilot Study of the Effect upon Multiple Sclerosis of the Menopause, Hormone Replacement Therapy and the Menstrual Cycle

A questionnaire enquiring about changes in severity of symptoms of multiple sclerosis with the menstrual cycle, menopause and use of hormone replacement therapy was answered retrospectively by 11 premenopausal and 19 postmenopausal women. Eighty-two per cent of menopausal women reported an increase in severity premenstrually. Of the postmenopausal women 54% reported a worsening of symptoms with the menopause, and 75% of those who had tried hormone replacement therapy reported an improvement. The results of this pilot study indicate the need for further research to clarify the effects of the menopause and hormone replacement therapy upon multiple sclerosis.
A new pregnane glycoside from Gomphocarpus fruticosus growing in Egypt

Abstract Phytochemical investigation of Gomphocarpus fruticosus (L.) Ait. of Egyptian origin afforded the new pregnane glycoside lineolon-3-O-[β-D-oleandropyranosyl-(1–4)-β-D-cymaropyranosyl-(1–4)-β-D-cymaropyranoside], along with six known compounds. The structures of the isolated compounds were elucidated on the basis of extensive spectroscopic evidences derived from 1D, 2D NMR experiments, mass spectrometry and by comparing their physical and spectroscopic data to literature. These included the triterpenoids 3β-taraxerol, 3β-taraxerol acetate and betulinic acid, which are identified for the first time in G. fruticosus and the cardenolides uzarigenin, gomphoside and calotropin.
Beta-Thromboglobulin During Normal Pregnancy, LABOR, and Puerperium1

Platelet activation has been implicated in the pathogenesis of several obstetrical conditions such as preeclampsia and intrauterine growth retardation. Plasma beta-thromboglobulin (BTG) concentration is an index of in vivo platelet activation. The purpose of this study was to establish normal values of plasma BTG during pregnancy, labor and puerperium. Plasma BTG concentrations were determined from 121 uncomplicated pregnant women, 20 women in labor, 20 puerperal women, and a control group of 28 healthy non-pregnant volunteers. There was no significant difference in plasma BTG concentrations between non-pregnant and pregnant women. Gestational age, labor, and puerperium did not affect plasma BTG concentrations.
The effect of Remin Pro® on bleached enamel hardness: an in-vitro study.

INTRODUCTION Remineralization as a treatment procedure has received a lot of attention both from clinicians as well as researchers. The objective of this study was to assess the effect of Remin Pro® on enamel microhardness after bleaching the teeth with McInnes bleaching agent using Vickers microhardness tester. MATERIALS AND METHODS In this study, freshly extracted ten central incisors were taken which were subjected to baseline indentation by using Vickers microhardness indenter and then McInnes bleaching solution was applied for 5 min to demineralize these teeth. Remin Pro a newer remineralizing agent was applied for 7 days, which showed an increase in microhardness at the end of 7 days. RESULTS The values were subjected for statistical analysis using paired t-test. All the samples showed a decrease in the microhardness after bleaching with McInnes solution. The decrease in mean hardness from baseline to demineralization was found to be statistically significant (P < 0.001). However, remineralizing the same tooth with Remin Pro for 7 days, showed an increase in hardness, which was found to be statistically significant (P < 0.05). CONCLUSION McInnes bleaching agent decreases the microhardness of enamel and Remin Pro® used in the study causes an increase in the microhardness of bleached enamel.
Process strategies to enhance pyruvate production with recombinant Escherichia coli: From repetitive fed‐batch to in situ product recovery with fully integrated electrodialysis

Using the pyruvate production strain Escherichia coli YYC202 ldhA::Kan different process alternatives are studied with the aim of preventing potential product inhibition by appropriate product separation. This strain is completely blocked in its ability to convert pyruvate into acetyl‐CoA or acetate, resulting in acetate auxotrophy during growth in glucose minimal medium. Continuous experiments with cell retention, repetitive fed‐batch, and an in situ product recovery (ISPR) process with fully integrated electrodialysis were tested. Although the continuous approach achieved a high volumetric productivity (QP) of 110 g L−1 d−1, this approach was not pursued because of long‐term production strain instabilities. The highest pyruvate/glucose molar yield of up to 1.78 mol mol−1 together with high QP 145 g L−1 d−1 and high pyruvate titers was achieved by the repetitive fed‐batch approach. To separate pyruvate from fermentation broth a fully integrated continuous process was developed. In this process electrodialysis was used as a separation unit. Under optimum conditions a (calculated) final pyruvate titer of >900 mmol L−1 (79 g L−1) was achieved. © 2004 Wiley Periodicals, Inc.
Adenocarcinoma of the Endometrium — The Art of Its Diagnosis

The diagnostic process begins at the first meeting with the patient, where we must relate the symptoms and signs associated with endometrial disease. Communication skills are fundamental for excellence in medical care. Even with the development and improve‐ ment of new technologies in recent decades, be it endoscopy, ultrasound, computed to‐ mography or magnetic resonance imaging, the communication is also essential. We must have skills to recognize and elucidate a wide variety of signs and symptoms when we take a history and do a physical examination of the patient, where abnormal uterine bleeding is the first main sign that can lead to an early diagnosis of endometrial cancer. The endometrium, as every target organ of steroid hormones, shows involutional changes during ovarian failure. In peri-menopause, however, tissue hyperactivity stages occur with some frequency, showing a marked endometrial sensitivity to hormonal fluc‐ tuations, whether on an absolute or relative level. Irregular blood loss occurs in many women during this period, and although being most times of functional origin, it requires investigation. It is noteworthy that the most frequent cause of abnormal bleeding of or‐ ganic origin in menopause is endometrial. Endometrial pathologies appear with advanc‐ ing age. Therefore an appropriate workup should diagnose or rule out disease at this site. Thus, preventive measures should be adopted, such as screening and early diagnosis, and the best treatment for the patient should be established.
Evaluation of density of Langerhans cells in human cervical intraepithelial neoplasia

Objective. To compare the number of Langerhans cells in areas of CIN 3 and in areas without histopathological alteration adjacent to CIN 3 with those found in histologically normal control cases. Material and methods. Specimens were obtained from 46 normal cervixes from women undergoing hysterectomies due to uterine leiomyomata and 71 from conization specimens for CIN 3. The identification of the Langerhans cells was performed by immunohistochemical analysis, using antibodies to S‐100 protein. The number of intraepithelial Langerhans cells was counted at a 400× magnification under light microscope and a 10 field count was performed in areas of epithelium of the normal cervix (group A), areas of CIN 3 in the conization specimens (group B), and areas of epithelium without histopathologic alteration adjacent to CIN 3 (group C). Results were expressed as number of cells per square millimeter of epithelium. Results. Comparing groups A and B, we observed that the number of Langerhans cells was significantly higher in the latter group; between groups A and C, the number of cells was significantly lower in the second group. The number of Langerhans cells was also compared between groups B and C and it was significantly lower in the latter, independent of smoking habits. Conclusions. We theorize that the increase in the population of Langerhans cells in areas of CIN 3 could be explained by migration of these cells from adjacent areas without histopathologic alterations in order to act in the restraint of the development of neoplasia; cigarette smoking did not influence this migration.
Stereotactic Brainstem Biopsy Is Indicated for the Diagnosis of a Vast Array of Brainstem Pathology

Background/Aims: A meta-analysis of thirteen studies performing stereotactic biopsy of brainstem lesions is combined with our recent series of 12 patients with brainstem lesions comparing MRI findings to biopsy histopathology to determine whether these lesions could have been diagnosed radiographically. Methods: 12 consecutive stereotactic biopsies and literature analysis were performed to analyze clinical, radiographic and histopathologic data. Results: Stereotactic biopsy of lesions in the brainstem was in 96% diagnostic. There was one mortality (3% of cases) and 4% morbidity associated with the procedure. Pathology showed that half of the adult brainstem intrinsic lesions were gliomas, 10% were metastases, and the remainder were hematomas, vascular malformations, lymphomas, demyelination, cysts, radiation necrosis, abscesses, vasculitis, infarcts, leukemia, cryptococcus, or granulomas. Conclusions: Empiric treatment of adult brainstem lesions is not prudent because there is a wide spectrum of diverse pathology in this location. Stereotactic biopsy is a safe and effective method for determining histopathology.
Sensory Innervation of the Female Human Umbilical Skin: Morphological Studies

Background: Sensory stimuli are conducted by several cutaneous sensory nerves and tactile corpuscles. The latter are specialized sensory organs that represent the starting point of many afferent sensory pathways. To date, our knowledge about the distribution of the sensory innervation in the umbilical skin of females is incomplete. Aim of the study: To elucidate the morphology of the cutaneous innervation of the normal female umbilical skin. Materials and methods: Biopsies of normal umbilical skin were obtained from female patients undergoing umbilical hernial repair. The specimens were processed for both immunohistological (antibodies against PGP9.5, pan-neuronal marker, and S-100 protein, marker of Schwann cells) and ultrastructural (transmission electron microscopy) examinations. Results: The authors found abundant genital end-bulb-like structures, numerous epidermal and dermal Merkel cells, Meissner and Ruffini corpuscles, intraepidermal nerve terminals, and multiple free nerve endings surrounding the ducts and acini of the sweat glands. Conclusions: The umbilical skin of females has abundant sensory innervation similar to that of the glans penis.
CONSISTENCY OF AUDITORY DETECTION JUDGMENTS.

An observer's decision in a psychoacoustic detection experiment is governed by two broad classes of determinants: (1) external determinants, such as the likelihood of a particular waveform being a signal in noise, and (2) internal determinants, the momentary state of the observer's nervous system, his response biases, or biases as to certain sequences of responses. The aim of the study was to determine, via a measure of the observer's consistency, the relative contribution of these factors. To achieve this end, the audio information presented during a sequence of two‐alternative forced‐choice trials was taped and repeated to the observer at a later time. The consistency of the observer's judgments was measured by determining a percent agreement score: the percent of times the subject agreed with his previous response on those special trials of the sequence in which no signal occurred on either interval of the forced‐choice trial. Percent agreements range between 80% and 55%, depending on the observer and,.