Miracle-dz/UniFAR-FTUs huggingface dataset:
Post-fire effects in xylem hydraulics of Picea abies, Pinus sylvestris and Fagus sylvatica.

Recent studies on post-fire tree mortality suggest a role for heat-induced alterations of the hydraulic system. We analyzed heat effects on xylem hydraulics both in the laboratory and at a forest site hit by fire. Stem vulnerability to drought-induced embolism and hydraulic conductivity were measured in Picea abies, Pinus sylvestris and Fagus sylvatica. Control branches were compared with samples experimentally exposed to 90°C or damaged by a natural forest fire. In addition, xylem anatomical changes were examined microscopically. Experimental heating caused structural changes in the xylem and increased vulnerability in all species. The largest shifts in vulnerability thresholds (1.3 MPa) were observed in P. sylvestris. F. sylvatica also showed heat-induced reductions (49%) in hydraulic conductivity. At the field site, increased vulnerability was observed in damaged branches of P. sylvestris and F. sylvatica, and the xylem of F. sylvatica was 39% less conductive in damaged than in undamaged branches. These results provide evidence for heat-induced impairment of tree hydraulics after fire. The effects recorded at the forest fire site corresponded to those obtained in laboratory experiments, and revealed pronounced hydraulic risks in P. sylvestris and F. sylvatica. Knowledge of species-specific hydraulic impairments induced by fire and heat is a prerequisite for accurate estimation of post-fire mortality risks.
The development of non-melanocytic skin cancers in people with a history of skin cancer.

OBJECTIVE To determine the incidence of new skin cancer formation in people who have had skin cancer removed. STUDY DESIGN A prospective study of Melbourne out-patients with histologically confirmed non-melanoma skin cancer (NMSC). All patients with NMSC seen by one author (D.C.) between November 1988 and November 1989 were entered into the study and reviewed regularly. New skin cancers were removed and recorded. RESULTS Four hundred and eighty-one patients were entered and 420 followed for at least 3 years. New NMSC developed in 60% (adjusted for losses) by the end of 3 years. A multivariate analysis determined that the main risk factor for new NMSC formation was the number of previous skin cancers that a patient had. Those who had had multiple skin cancers (3 or more) were at significantly greater risk than those with less than 3. Age, sex and type of NMSC were not risk factors for new skin cancer formation. CONCLUSION Patients with NMSC require long-term follow-up because of the risk of new skin cancer formation. Those with multiple NMSC need more careful follow-up, and possibly more frequent examinations, because they are at greater risk.
You can go your own way: effectiveness of participant-driven versus experimenter-driven processing strategies in memory training and transfer

ABSTRACT Cognitive training programs that instruct specific strategies frequently show limited transfer. Open-ended approaches can achieve greater transfer, but may fail to benefit many older adults due to age deficits in self-initiated processing. We examined whether a compromise that encourages effort at encoding without an experimenter-prescribed strategy might yield better results. Older adults completed memory training under conditions that either (1) mandated a specific strategy to increase deep, associative encoding, (2) attempted to suppress such encoding by mandating rote rehearsal, or (3) encouraged time and effort toward encoding but allowed for strategy choice. The experimenter-enforced associative encoding strategy succeeded in creating integrated representations of studied items, but training-task progress was related to pre-existing ability. Independent of condition assignment, self-reported deep encoding was associated with positive training and transfer effects, suggesting that the most beneficial outcomes occur when environmental support guiding effort is provided but participants generate their own strategies.
Stereotactic ablative radiotherapy for hepatocellular carcinoma: History, current status, and opportunities

A variety of surgical and other local‐regional approaches to the management of hepatocellular carcinoma (HCC) are in clinical use. External beam radiation therapy is a relative newcomer to the portfolio of treatment options. Advances in planning and delivery of radiation therapy, developing in parallel with and inspiring changing paradigms of tumor management in the field of radiation oncology, have led to growing interest in radiation therapy as a viable treatment option for HCC as well as other liver tumors. In this review, we discuss these advances, current trends in liver radiotherapy, as well as avenues of future clinical and basic research. Liver Transplantation 24 420–427 2018 AASLD.
Effect of Dietary Intake on Urinary Oxalate Excretion in Calcium Oxalate Stone Formers in Their Forties

Purpose: To examine the influence of dietary intake on urinary oxalate excretion in calcium oxalate stone formers in their forties.Patients and Methods: Dietary intake was recorded by using the dietary–record method in 58 idiopathic stone formers in their forties. The patients collected their urine for 24 h at home and their urinary oxalate excretion was measured. The relationship between the dietary intake of various nutrients and urinary oxalate excretion was examined by mono– and multivariate analysis.Results: The intake of animal fat was correlated with urinary oxalate excretion by monovariate analysis, but that of total protein, animal protein, calcium and carbohydrate were not. By multivariate analysis, the intake of animal fat was correlated with urinary oxalate excretion and the intake of calcium was inversely correlated with urinary oxalate excretion.Conclusion: The intake of animal fat was positively and the intake of calcium was negatively correlated with the urinary oxalate excretion in stone formers in their forties. It was shown that animal fat plays an important role in urinary oxalate excretion.
Minimal preparation CT: A literature review of a minimally invasive imaging technique for colorectal cancer in a frail, aged population

Colorectal cancer (CRC) is a common malignancy with increased incidence in the elderly. When CRC is suspected, patients are typically evaluated with optical colonoscopy (OC) or CT Colonography (CTC). Unfortunately, in the frail and elderly patient, these investigations can be difficult to perform and are often not tolerated. Minimal preparation computed tomography (MPCT) is a CT technique to evaluate the colon. Although protocols vary, typically, no preparation is required apart from administration of oral contrast for faecal tagging. The patient is scanned in the supine position only and without colonic insufflation. The study is reserved for ‘old‐old’ frail patients with clinically suspected CRC who cannot tolerate or have failed OC or CTC. In the context of an ageing population, MPCT provides a simple, minimally invasive, readily available and well‐tolerated test that is able to demonstrate clinically relevant disease. We review the literature on MPCT and discuss the benefits and limitations of this investigation.
The temperature of storage of a batch of wheat distillers dried grains with solubles samples on their nutritive value for broilers

ABSTRACT 1. A batch of wheat distillers dried grains with solubles (DDGS) was obtained immediately after production and was separated into 5 equal parts and placed in woven polypropylene sacks. The samples were stored under 5 different temperature conditions for 1 year as follows: kept at a constant −20°C; kept at −20°C for 24 h period and after that kept at a constant +4°C; kept at a constant +4°C only; kept at a constant +15°C; stored at ambient temperature (range of weekly mean temperatures was from +4 to +22°C). 2. Each of the 5 wheat DDGS samples was included (200 g/kg) in a nutritionally complete diet and fed to broiler chickens from 7 to 21 d of age. The chemical composition of the DDGS samples was determined at the beginning and at the end of the 1-year storage period. 3. The nitrogen corrected apparent metabolisable energy (AMEn) and the nutrient availability of each sample was measured using a total collection technique. The growth performance of birds was also determined. 4. The DDGS samples kept at a constant −20°C had higher dry matter, lower oxidation value and lower antioxidant contents. The DDGS sample that was stored at ambient temperatures had a higher AMEn than the rest of the DDGS samples. 5. The results of this experiment have shown that there can be changes in the AMEn of wheat DDGS during storage at ambient temperatures. In general, there were no serious effects of storage of DDGS on its feeding value to broiler chickens.
Quantitative CrAssphage real‐time PCR assay derived from data of multiple geographically distant populations

After its computational inference from human stool metagenomes, the CrAssphage has proven to be the most prevalent phage in the human gut, with presumably very wide geographic distribution. The currently available molecular assays do not sufficiently reflect the CrAssphage sequence variability. Here, we report a novel real‐time PCR assay whose primers and probes are derived from data of multiple CrAssphage strains obtained from gut viral metagenomes of European, Asian, and African subjects. This assay can be useful in analyses of putative bacterial host co‐occurence, and in association studies of non‐infectious diseases where the phage may modify the content of gut bacteriomes.
Monitoring Asthma Severity and Response to Treatment

Guidelines for the management of asthma rely on various methods of assessing severity and how it changes in order to select the appropriate treatment. These methods have been developed from the basic clinical skills of history taking and physical examination to which attempts at improving objectivity have been added, such as the use of asthma diaries, the home recording of peak expiratory flow (PEF) or measurements of bronchial reactivity. The present review was an attempt to determine to what extent monitoring asthma by various techniques is justified. Unfortunately, diaries and home recording of PEF are easily faked and generally unreliable while objective tests, such as the measurement of bronchial reactivity or studies of induced sputum cannot be undertaken often enough for monitoring, and there is certainly the need for prospective longitudinal controlled studies.
Sparrow Nest Survival in Relation to Prescribed Fire and Woody Plant Invasion in a Northern Mixed-Grass Prairie

Prescribed fire is used to reverse invasion by woody vegetation on grasslands, but managers often are uncertain whether influences of shrub and tree reduction outweigh potential effects of fire on nest survival of grassland birds. During the 2001–2003 breeding seasons, we examined relationships of prescribed fire and woody vegetation to nest survival of clay-colored sparrow (Spizella pallida) and Savannah sparrow (Passerculus sandwichensis) in mixed-grass prairie at Des Lacs National Wildlife Refuge in northwestern North Dakota, USA. We assessed relationships of nest survival to 1) recent fire history, in terms of number of breeding seasons (2, 3, or 4–5) since the last prescribed fire, and 2) prevalence of trees and tall (>1.5 m) shrubs in the landscape and of low (≤1.5 m) shrubs within 5 m of nests. Nest survival of both species exhibited distinct patterns related to age of the nest and day of year, but bore no relationship to fire history. Survival of clay-colored sparrow nests declined as the amount of trees and tall shrubs within 100 m increased, but we found no relationship to suggest nest parasitism by brown-headed cowbirds (Molothrus ater) as an underlying mechanism. We found little evidence linking nest survival of Savannah sparrow to woody vegetation. Our results suggest that fire can be used to restore northern mixed-grass prairies without adversely affecting nest survival of ≥2 widespread passerine species. Survival of nests of clay-colored sparrow may increase when tall woody cover is reduced by fire. Our data lend support to the use of fire for reducing scattered patches of tall woody cover to enhance survival of nests of ≥1 grassland bird species in northern mixed-grass prairies, but further study is needed that incorporates experimental approaches and assessments of shorter term effects of fire on survival of nests of grassland passerines. © 2017 This article is a U.S. Government work and is in the public domain in the USA.
Interleukin-6 Concentrations in Cervical Secretions in the Prediction of Intrauterine Infection in Preterm Premature Rupture of the Membranes

The objective of this study was to determine the value of interleukin-6 (IL-6) in cervical secretion to diagnose microbial invasion of the amniotic cavity in patients with premature rupture of the membranes. Cervical secretions were sampled immediately before amniocentesis in 124 patients with singleton pregnancies and preterm premature rupture of the membranes. Gestational age ranged between 24 and 32 weeks. Amniotic fluid was cultured and IL-6 measured in amniotic fluid and cervical secretions. A total of 33.8% (21/124) of the amniotic fluid cultures had positive results. In cervical secretions the median concentration of IL-6 was 672 pg/ml (range 5–1,250) in the presence of intra-amniotic infection in contrast to 95.5 pg/ml (range 12–640) in women with negative amniotic fluid culture (p ≤0.001). There were no differences between IL-6 concentrations in the cervical secretions of patients with or without obvious leakage of amniotic fluid. A significant relationship was found between IL-6 levels in amniotic fluid and in cervical secretions (ρ = 0.74, p ≤0.001). An IL-6 level in cervical secretions >200 pg/ml had a sensitivity of 78.5%, a specificity of 73.1% and a relative risk of 4.6 for intra-amniotic infection. Receiver-operator characteristics curve analysis showed that IL-6 assay in cervical secretions is comparable to IL-6 assay in amniotic fluid in predicting intra-amniotic infection (p = 0.468). In conclusion, intra-amniotic infection is associated with increased levels of IL-6 and concentrations in cervical secretions are related to amniotic levels. The measurement of IL-6 in cervical secretions may help to noninvasively identify intra-amniotic infection among pregnancies with preterm premature rupture of membranes.
SIENA‐XL for improving the assessment of gray and white matter volume changes on brain MRI

In this article, SIENA‐XL, a new segmentation‐based longitudinal pipeline is introduced, for: (i) increasing the precision of longitudinal volume change estimation for white (WM) and gray (GM) matter separately, compared with cross‐sectional segmentation methods such as SIENAX; and (ii) avoiding potential biases in registration‐based methods when Jacobians are used, with a smoothing extent larger than spatial scale between tissue‐interfaces, which is where atrophy usually occurs. SIENA‐XL implements a new brain extraction procedure and a multi‐time‐point intensity equalization step before performing the final segmentation that also includes separate segmentation of deep GM structures by using FMRIB's Integrated Registration and Segmentation Tool. The detection of GM and WM volume changes with SIENA‐XL was evaluated using different healthy control (HC) and multiple sclerosis (MS) MRI datasets and compared with the traditional SIENAX and two Jacobian‐based approaches, SPM12 and SIENAX‐JI (a version of SIENAX including Jacobian integration ‐ JI). In scan‐rescan data from HCs, SIENA‐XL showed: (i) a significant decrease in error, of 50–70% when compared with SIENAX; (ii) no significant differences in error when compared with SIENAX‐JI and SPM12 in a scan‐rescan HC dataset that included repositioning. When tested in a HC dataset with scan‐rescan both at baseline and after 1 year of follow‐up, SIENA‐XL showed: (i) significantly higher precision (P < 0.01) than SIENAX; (ii) no significant differences to SIENAX‐JI and SPM12. Finally, in a dataset of 79 MS patients with a 2 years follow‐up, SIENA‐XL showed a substantial reduction of sample size, by comparison with SIENAX, SIENAX‐JI, and SPM12, for detecting treatment effects of 25, 30, and 50%. Hum Brain Mapp 39:1063–1077, 2018. © 2017 Wiley Periodicals, Inc.
CrossTalk proposal: an important astrocyte‐to‐neuron lactate shuttle couples neuronal activity to glucose utilisation in the brain

The astrocyte-to-neuron lactate shuttle (ANLS) hypothesis was proposed based on glutamate experiments with cultured cells (Pellerin & Magistretti, 1994). Later on, comparative NMR spectroscopy confirmed that cultured astrocytes are more glycolytic than neurons (Bouzier-Sore et al. 2006), a metabolic divergence that has later been explained by constitutive inhibition of phosphofructokinase in neurons but not in astrocytes, which diverts the neuronal glucose flux towards the pentose phosphate pathway (Herrero-Mendez et al. 2009). Since then, other neuronal signals have been found to be capable, like glutamate, of commanding the production and/or
The Impact of Depressive Symptoms and Traumatic Experiences on Quality of Life in Adults With ADHD

Objective: We assessed factors influencing quality of life (QoL) in adults with ADHD. Method: QoL, traumatic childhood experiences, and depression were assessed using the Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q), Childhood Trauma Questionnaire (CTQ), and Beck Depression Inventory (BDI), respectively, in 60 adult ADHD outpatients and 60 age- and gender-matched controls. Results: Emotional neglect or abuse had occurred significantly more often during childhood in adults with ADHD. Depressive symptoms were rated significantly higher by ADHD patients. QoL was significantly lower in adults with ADHD, and the variables depression, ADHD symptom severity, and traumatic load, accounted for ~60% of variance in overall QoL. Conclusion: QoL is significantly reduced in adult ADHD patients. Depressive symptoms and traumatic childhood experiences influence QoL. Treatment for adult ADHD patients should take the high interdependence of depressive symptoms, childhood trauma, and QoL into consideration.
Challenges in the diagnosis of acute cyanide poisoning

Abstract Objective: The aim of this systematic review was to identify isolated acute cyanide poison cases and to identify reported signs, symptoms, and laboratory findings. Methods: We searched MEDLINE, Cochrane Reviews, and Web of Science case reports and series using a number of MeSH descriptors pertaining to cyanide, toxicity, and poisonings. We excluded studies on plants, laboratory analyses, smoke inhalation poisonings, animals as well as non-English language articles and those in which data were not available. Data extracted included demographics, exposure characteristics, acute signs/symptoms, and medical management and outcome. Results: From the initial 2976 articles retrieved, 65 articles (52 case reports, 13 case series) met inclusion criteria and described 102 patients. Most patients were unresponsive (78%), hypotensive (54%), or had respiratory failure (73%); other signs and symptoms included cardiac arrest (20%), seizures (20%), cyanosis (15%), cherry red skin (11%), and had an odor present (15%). Medical management included cyanide antidote kit (20%), sodium thiosulfate (40%), and hydroxocobalamin (29%). The majority of cases (66%) required intubation with mechanical ventilation and a substantial number (39%) developed refractory hypotension requiring vasopressor support. Conclusions: Contrary to general reviews published on cyanide toxicity, reports of cherry red skin and bitter almond odor were rare among published cyanide cases. Consistent with other studies, metabolic acidosis with significant lactic acidosis were the laboratory values consistently associated with cyanide toxicity. Healthcare providers may overlook cyanide toxicity in the differential diagnosis, if certain expected characteristics, such as the odor of almonds or a cherry red color of the skin are absent on physical examination.
Understanding Teacher Change: A National Survey of U.S. Physical Educators

ABSTRACT Physical education is critical to addressing childhood obesity, yet many school-based programs do not meet established quality standards and teachers are called upon to change. Little is known about how change is initiated and its associated internal and external factors. Purpose: The purpose of this study was to investigate physical education teacher change that was self-initiated and externally initiated and to examine dispositions toward the change process relative to initiation. Method: A random national sample of physical educators representing each SHAPE America – Society of Health and Physical Educators regional district participated in a survey measuring past programming changes, primary initiators of change, and teachers’ dispositions toward change. In total, 2,423 teachers (46% response rate) completed electronic, paper, or telephone questionnaires. Results: Teachers most often made minor curriculum changes, and they added/subtracted student assessments (primarily informal assessments) least often. Self-initiated (bottom-up) change was most frequently (83.1% of the time) reported. Externally initiated (top-down) changes were less frequent and were most often associated with professional development. Teachers reported principals’ involvement in both top-down and bottom-up change processes was minimal. Teachers who were more disposed to making future changes reported making significantly (p < .01, η2 = .046–.119) more past changes than those who were less disposed to change. Conclusions: Physical education teachers primarily self-initiated minor programming changes without involvement from administration. Externally initiated change was infrequent and mostly involved professional development. Dispositions toward change were individual and enduring such that teachers who had made more past changes were more likely to also make future changes.
Spectroscopic investigation on interaction of biogenic, Croton bonplandianum leaves extract mediated potential bactericidal silver nanoparticles with human hemoglobin and human serum albumin

The green synthesis of nanoparticles has received increasing attention due to the growing demand to produce safe, cost-effective, and eco-friendly technology for nanomaterials synthesis. We report on the use of aqueous Croton bonplandianum (Family: Euphorbiaceae, Genus: Croton) leaves extract for the preparation of silver nanoparticles (AgNPs) without using any external reducing and stabilizing agent. Ultraviolet–visible spectroscopy showed maximum absorbance at 446 nm due to surface plasmon resonance of AgNPs. Energy dispersive X-ray spectra also supported the existence of AgNPs. An average diameter (d = ~17.4 nm) of the spherical AgNPs was determined from the transmission electron microscopic images. Hydrodynamic size (d = ~21.1 nm) was determined by dynamic light scattering. Fourier transform infrared analysis designed that the functional groups like O–H, N–H, , CONH2, and COOH participated in the AgNPs formation. The negative zeta potential value (−19.3 mV) of the AgNPs indicated its dispersion and stability. The AgNPs exhibited strong antibacterial activity against Escherichia coli ATCC 25922 and 1.5 nM proved to be minimum inhibitory concentration for it. Hemolysis assay demonstrated the blood compatibility of the AgNPs toward human RBCs. The binding affinity of the AgNPs toward human hemoglobin and human serum albumin (HSA) was also determined by means of fluorescence spectroscopy. The circular dichroism spectroscopy revealed that the native structures of human hemoglobin and HSA remain unchanged, but its secondary structures were slightly changed upon interaction with AgNPs. Overall, it can be concluded that the AgNPs may be applied in the area of nanomedicines.