Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparison of physiological responses to graded exercise test performance in outrigger canoeing

Abstract The aim of this study was to establish a graded exercise test protocol for determining the peak physiological responses of female outrigger canoeists. Seventeen trained female outrigger canoeists completed two outrigger ergometer graded exercise test protocols in random order: (1) 25 W power output for 2 min increasing by 7.5 W every minute until exhaustion; and (2) 25 W power output for 2 min increasing by 15 W every 2 min to exhaustion. Heart rate and power output were recorded every 15 s. Expired air was collected continuously and sampled for analysis at 15-s intervals, while blood lactate concentration was measured immediately after and 3, 5, and 7 min after exercise. The peak physiological and performance variables examined included peak oxygen uptake ([Vdot]O2peak), minute ventilation, tidal volume, ventilatory thresholds 1 and 2, respiratory rate, respiratory exchange ratio, heart rate, blood lactate concentration, power output, performance time, and time to [Vdot]O2peak. There were no significant differences in peak physiological responses, ventilatory thresholds or performance variables between the two graded exercise test protocols. Despite no significant differences between protocols, due to the large limits of agreement evident between protocols for the peak physiological responses, it is recommended that the same protocol be used for all comparison testing to minimize intra-individual variability of results.
O-Phenyl (cyclohexylamido)(p-tolylamido)phosphinate

In the title molecule, C19H25N2O2P, the P atom is bonded in a distorted tetrahedral environment. The dihedral angle between the two phenyl rings is 89.09 (8)°. The methyl H atoms are disordered over two sets of sites with equal occupancy. The O atom of the P=O group acts as a double hydrogen-bond acceptor of the type (N—H)2⋯(O=)P—, forming R 2 2(8) rings which are further linked into chains along [010].
A blood lead benchmark for assessing risks from childhood lead exposure

Lead exposure is an insidious problem, causing subtle effects in children at low exposure levels where clinical signs are not apparent. Although a target blood lead concentration (PbB) of ten micrograms per deciliter (10 μg/dL) has been used as the basis for environmental decision-making in California for nearly two decades, recent epidemiologic evidence suggests a relationship between cognitive deficits and PbB at concentrations < 10 μg/dL. Based on a published meta-analysis of children's IQ scores and their blood lead concentrations, we developed a new blood lead benchmark: an incremental increase in blood lead concentration (ΔPbB) of 1 μg/dL, an increase that we estimate could decrease the IQ score in an average school child in California by up to one point. Although there is no evidence to date for a threshold for the neurobehavioral effects of lead, a one-point IQ decrement was chosen to represent a de minimus change. To safeguard the intellectual potential of all children, additional efforts to reduce or eliminate multiple-source exposures to lead are warranted.
EPILEPTIC SEIZURES IN WOMEN RELATED to PLASMA ESTROGEN and PROGESTERONE DURING the MENSTRUAL CYCLE

Nine periods in seven women with partial epilepsy have been investigated with respect to frequency of fits, and estrogen‐progesterone levels in blood plasma. Six cycles with ovulation showed a positive correlation between the number of secondary generalized seizures and the mean estrogen/progesterone (E/P) ratios and a negative correlation to plasma progesterone levels. Three periods without ovulation showed an increase in the number of fits during days of high estrogen. the number of fits seemed not to be correlated to changes in body weight.
Toward an aesthetic epistemology: Transforming thinking through cybernetic epistemology and anthroposophy

The complexity, subtlety, interlinking, and scale of many problems faced individually and collectively in today’s rapidly changing world requires an epistemology—a way of thinking about our knowing—capable of facilitating new kinds of responses that avoid recapitulation of old ways of thinking and living. Epistemology, which implicitly provides the basis for engagement with the world via the fundamental act of distinction, must therefore be included as a central facet of any practical attempts at self/world transformation. We need to change how we think, not just what we think. The new epistemology needs to be of a higher order than the source of the problems we face. This theoretical, transdisciplinary dissertation argues that such a new epistemology needs to be recursive and process-oriented. This means that the thoughts about thinking that it produces must explicitly follow the patterns of thinking by which those thoughts are generated. The new epistemology is therefore also phenomenological, requiring the development of a reflexivity in thinking that recursively links across two levels of order—between content and process. The result is an epistemology that is of (and for) the whole human being.
Effect of provider and patient reminders, deployment of nurse practitioners, and financial incentives on cervical and breast cancer screening rates.

OBJECTIVE To evaluate the effect of the Provider and Patient Reminders in Ontario: Multi-Strategy Prevention Tools (P-PROMPT) reminder and recall system and pay-for-performance incentives on the delivery rates of cervical and breast cancer screening in primary care practices in Ontario, with or without deployment of nurse practitioners (NPs). DESIGN Before-and-after comparisons of the time-appropriate delivery rates of cervical and breast cancer screening using the automated and NP-augmented strategies of the P-PROMPT reminder and recall system. SETTING Southwestern Ontario. PARTICIPANTS A total of 232 physicians from 24 primary care network or family health network groups across 110 different sites eligible for pay-for-performance incentives. INTERVENTIONS The P-PROMPT project combined pay-for-performance incentives with provider and patient reminders and deployment of NPs to enhance the delivery of preventive care services. MAIN OUTCOME MEASURES The mean delivery rates at the practice level of time-appropriate mammograms and Papanicolaou tests completed within the previous 30 months. RESULTS Before-and-after comparisons of time-appropriate delivery rates (< 30 months) of cancer screening showed the rates of Pap tests and mammograms for eligible women significantly increased over a 1-year period by 6.3% (P < .001) and 5.3% (P < .001), respectively. The NP-augmented strategy achieved comparable rate increases to the automated strategy alone in the delivery rates of both services. CONCLUSION The use of provider and patient reminders and pay-for-performance incentives resulted in increases in the uptake of Pap tests and mammograms among eligible primary care patients over a 1-year period in family practices in Ontario.
Inversion and circularization of the varicella-zoster virus genome

The genome of varicella-zoster virus (VZV) is a linear, double-stranded molecule of DNA composed of a long (L) region covalently linked to a short (S) region. The S region is capable of inverting relative to a fixed orientation of the L region, giving rise to two equimolar populations. We have investigated other forms of the VZV genome which are present in infected cells and packaged into nucleocapsids. That a small proportion of nucleocapsid DNA molecules also possess inverted L regions has been verified by the identification of submolar restriction fragments corresponding to novel joints and novel ends generated by such an inversion. The presence of circular molecules has been investigated by agarose gel electrophoresis. Bands corresponding to circular forms were present in small amounts in both VZV-infected cell DNA and nucleocapsid DNA. Southern blot analysis verified that these bands contained VZV sequences. We therefore conclude that the VZV genome may occasionally contain an inverted L region or exist in a circular configuration.
Aspects of Context in Daily Search Activities - Survey about Nowadays Search Habits

Over almost 70 years of perpetual improvement, Information Retrieval (IR), has had many approaches to satisfy one’s information need. In this paper, we want to put forward and measure the importance of the inclusion of a contextual dimension to enhance the relevance and effectiveness of a search task. Indeed, a search task is no more concerned with a query and a set of documents only, but it is related to a wide range of some extrinsic and intrinsic factors, so called “context”, which became a great challenge these last few years. Besides the emergence and the significance of the use of context in IR, we conducted a survey with 434 internet users to understand their search trends and habits. The results and discussion may contain valuable information for future researchers.
Brand equity and customer behavioral intentions: a mediated moderated model

Purpose The purpose of this paper is to examine the relationship between brand equity and customer behavioral intentions to repeat purchases, willingness to pay a price premium, switch and provide positive word of mouth. It further explores the mediating role of customer satisfaction and the moderating impact of customer age, education and gender on these relationships. Design/methodology/approach Data were collected from 283 banking customers and analyzed with structural equation modeling. Findings The results supported a strong relationship between brand equity and all four measures of behavioral intent with customer satisfaction partially mediating these relationships. In addition, the results supported the moderating effect of customer age and education on the customer satisfaction-switch relationship. Practical implications The study provides a useful perspective on the impact of brand building investments on consumers’ behavioral intentions, which bank managers can use to monitor and evaluate the outcome of branding initiatives and relationship management strategies. Originality/value The study provides a nuanced understanding of the effect of brand equity on consumer behavioral intentions. It also explains the mediating and moderating effects of customer satisfaction and demographical characteristics.
Development of an Orogastrointestinal Mucosal Model of Candidiasis with Dissemination to Visceral Organs

ABSTRACT Studies were done to develop a murine model that mimics the pattern of mucosal candidiasis followed by disseminated disease seen in patients given cytotoxic chemotherapy. Developmental studies showed that suppression of mice with 5-fluorouracil beginning 3 days prior to infection and given every 7 days thereafter necessitated antibacterial treatment but resulted in a reproducible model. Candida albicans given in the drinking water resulted in oral infection by day 3 that significantly increased from days 10 to 15 and mucosal infection with 4 to 7 log10Candida CFU in the esophagus, stomach, small intestine, and cecum. Dissemination to livers occurred and was 100% on days 5 to 15; fewer animals had kidney infection. The median kidney or liver CFU were 2 or 3 log10 CFU, respectively, on day 15; despite this, mortality was low through 21 days of infection. As a demonstration of the utility of the model to test antifungal activity, daily treatment with 10 or 50 mg/kg itraconazole significantly reduced dissemination to the liver and kidneys and reduced tongue CFU compared to controls. Overall, these studies indicate that a nonlethal model of oral and gastrointestinal mucosal candidiasis with dissemination can be established in mice. Drug efficacy in treating localized infection and in preventing or treating disseminated infection can be studied.
Can Your Advertisement Go Abstract Without Affecting Willingness to Pay?

ABSTRACT Advertising can focus on concrete product attributes or on lifestyle expressions and abstract benefits. In the context of print advertising for luxury brands, the authors explored the relationship among advertising style (product-based versus lifestyle-building), advertising language (abstract versus concrete), and consumers' willingness to pay through the lens of construal level theory, which analyzes the way consumers interpret the brand. The study found that lifestyle branding was related to high language abstractness; product-based branding was related to language concreteness; and construal level was a mediator, enhancing willingness to pay when low. The use of abstract language and lifestyle-based advertising therefore requires careful consideration.
Time course of the electrophysiological effects of quinidine on canine cardiac Purkinje fibers: concentration dependence and comparison with lidocaine and disopyramide.

We used standard microelectrode techniques to observe the time course of the appearance and disappearance of the cellular electrophysiologic effects of antiarrhythmic drugs during drug infusion and after washout. The slopes of phases 0 (Vmax), 2(V2) and 3(V3) of the action potential of canine Purkinje fibers were followed during 30 min of infusion of quinidine (0.2 - 1 x 10(-5) M), disopyramide (1 x 10(-5) M) or lidocaine (1 x 10(-5) M) and then during 60 min of washout with drug-free Tyrode's solution. All three drugs significantly reduced V3 and increased V2; quinidine and disopyramide also significantly reduced Vmax. The onset of the effects of quinidine and disopyramide on Vmax, V2 and V3 occurred at similar rates. Both the onset and disappearance of the effects of lidocaine were more rapid than those of quinidine and disopyramide. This may have been related to the greater lipid solubility of lidocaine with a heptane: water partition coefficient of 0.85 for lidocaine compared with 0.16 for disopyramide and 0.06 for quinidine. The effects of quinidine (1 x 10(-5) M) on V3 reversed much more slowly upon washout (T1/257 +/- 12 min, mean +/- S.E.) than the effects of quinidine on Vmax (T1/218 +/- 3 min, P less than .01) and V2 (T1/215 +/- 3 min, P less than .01). Concentration-response data showed that the time course of washout of the effects of quinidine was independent of drug concentration. These data suggest that rapidity of antiarrhythmic drug action is related to lipophilicity and that the effect of quinidine on V3 is due to action at a different cellular site from its effects on Vmax and V2.
In-use product and steel stocks sustaining the urbanization of Xiamen, China

ABSTRACT Introduction: In-use product and material stocks are the amount of concerned manufactured products and materials in active use, and are essential components of urban ecosystem. Methods: This study estimates the dynamic in-use stocks of steel-containing products and steel in the city of Xiamen, China, during 1980–2015 by applying a bottom-up accounting approach. We incorporate 55 categories of steel-containing products that are classified into five end-use sectors (i.e., buildings, infrastructure, transportation equipment, machinery, and domestic appliances). Outcomes and Discussion: In-use stocks of 51% of the studied products kept increasing during 1980–2015, especially after 2000. Steel stocks have grown up to 4.9 ± 1.4 tons per capita (t/cap) in 2015, from 0.5 ± 0.2 t/cap in 1980. Buildings are the largest reservoirs, although its share decreased from 89% in 1980 to 68% in 2015. The dynamic spatial distribution indicates that steel stocks gradually expanded from urban core to suburban areas. Conclusion: Theresults help to explore how a city’s urbanization is sustained by the in-use stocks growth. In-use steel stocks, of which the growth is highly correlated to and probably driven by the population growth, GDP increase, and urban built-up area expansion, may serve as a supplementary indicator for urbanization.
Tacrolimus for the treatment of systemic lupus erythematosus with pure class V nephritis.

OBJECTIVES The treatment of pure membranous (class V) lupus nephropathy remains unsatisfactory. We studied the efficacy and safety of tacrolimus in the treatment of membranous nephritis secondary to SLE. METHODS We recruited 18 consecutive SLE patients (tacrolimus group) with recently confirmed biopsy-proven class V lupus nephritis. They were treated with a tailing dose of oral prednisolone and tacrolimus 0.1-0.2 mg/kg/day for 6 months, followed by maintenance prednisolone and AZA. The rate of resolution of proteinuria and SLEDAI were compared with 19 historical controls treated with oral cyclophosphamide or AZA (control group). All patients were followed for 12 months. RESULTS Baseline clinical characteristics were comparable between the groups. For the tacrolimus group, the complete and partial remission rates were 27.8 and 50.0%, respectively at 12 weeks; for the control group, they were 15.8 and 47.4%, respectively (overall chi-square test, P = 0.5). However, tacrolimus group had faster resolution of proteinuria than the control group by the general linear model with repeated measures (P = 0.032). At 12 weeks, proteinuria was reduced by 76.2 +/- 17.0% for the tacrolimus group and 47.1 +/- 51.1% for the control group (P = 0.028). Serial change in renal function and SLEDAI score did not differ between the groups. During the study period, four patients of the tacrolimus group, and 11 of the control group, developed lupus flare (P = 0.027). There was no serious adverse effect in the tacrolimus group. CONCLUSIONS A 6-month course of tacrolimus is a safe and effective treatment of pure class V (membranous) lupus nephritis. As compared with conventional cytotoxic treatment, tacrolimus possibly results in a faster resolution of proteinuria, and a lower risk of lupus flare within 1 yr. The long-term effect and optimal regimen of tacrolimus require further study.
Sorghum is a suitable break crop to minimise Fusarium pseudograminearum in any location regardless of climatic differences, whereas Gibberella zeae is location and climate specific

The susceptibility of grain sorghum (Sorghum bicolor) to infection and colonisation by Fusarium pseudograminearum and Gibberella zeae was assessed by isolation studies involving plants grown in field plots and commercial fields in New South Wales. F. pseudograminearum was isolated at a low frequency from plants sampled from an experimental trial site at Livingston Farm, Moree where five different residue management practices had been implemented. In this trial site, 1000 plants were analysed at the pre- and post-senescence stages from four replicate plots in each of five residue management treatments. There was an insignificant level of recovery of F. pseudograminearum from sorghum from the different treatments and inoculum levels. No G. zeae was isolated from this trial site. The effect of agro-climate factors on the occurrence of F. pseudograminearum and G. zeae in mature sorghum stems was assessed from 31 commercial sites representing two climatic regions, Goondiwindi/Moree and the Liverpool Plains. F. pseudograminearum was rarely isolated from the commercial crops that were from two different climatic regions. In contrast, G. zeae was isolated at low to medium levels from the Liverpool Plains region as this region has been identified as suitable for survival of this pathogen. The result also indicated that infection and colonisation of G. zeae was dependent on inoculum levels present in the residues of the preceding crop in the field and in the presence of medium to high rainfall distribution in areas that were detrimental to dispersal and initiation of infection. However, G. zeae was not isolated from sorghum stalks from the Goondiwindi/Moree region. In addition, G. zeae was more frequently isolated from sorghum crops where the wheat residues were known to be infested with G. zeae.
Which Aspects of CSR Predict Firm Market Value?

Purpose There is evidence that corporate social responsibility (CSR) practices predict higher firm value, but little evidence on which specific aspects of CSR drive this relationship. The purpose of this paper is to study this question in a sample drawn from 35 countries over 2003-2016. Design/methodology/approach The authors employ a research design that analyzes observational data with panel data methods including ordinary least squares, firm-random effects, and firm-fixed effects. Findings The authors find in a sample drawn from 35 countries over 2003-2016 an economically significant relationship between an overall CSR measure and firm value. The overall CSR score builds on data from Asset4 and is comprised of three indices for environmental, social, and corporate governance aspects of CSR. The authors find that the social index consistently predicts higher market value. The authors also show that the use of particular elements of CSR can lead to substantial omitted variables bias when predicting firm value. The results also suggest a similar bias in studies that focus on a single index, which captures a specific aspect of CSR, but omits the remaining aspects. Research limitations/implications The study is subject to limitations common to observational studies. Practical implications The authors find robust evidence that CSR predicts market value using a country-benchmarked overall CSR index. The power to predict firm value comes solely from the social dimension of this measure, which captures firm-level practices related to treatment of employees and stakeholder relations including those with customers and the broader community. Three elements drive the social index: customer/product responsibility, human rights, and employment quality. None of the remaining 12 elements significantly predicts firm vale in an empirical setting with firm-FE and extensive covariates. The authors also show that omitted aspects of CSR can easily lead to an omitted variable bias and that the magnitude of this bias is potentially greater with an OLS specification. Social implications Among the many dimensions of CSR, only a subset drives firm value. Policies that target to improve the CSR performance of firms adopt a broader definition of CSR. Originality/value The authors provide first-hand evidence on which specific aspects of CSR drive firm market value.