Miracle-dz/UniFAR-FTUs huggingface dataset:
Applying Learning-to-Rank to Human Resourcing's Job-Candidate Matching Problem: A Case Study.

A challenge that every company or organization will continue to face regularly is the task of recruiting people that will perfectly fit their vacant jobs. This is especially vital for companies in the Human Resourcing industry, like employment agencies and secondment companies, whose livelihood depend on selecting the right candidates. This selection process is currently performed by Human Resourcing professionals. The first step commonly consists of manually searching through the available applicants, eventually producing a list of suitable candidates that get invited to the next phase of the application process. This already labor intensive process has been made even more challenging with the advent of online job recruitment. This made finding and posting vacancies simpler, but also increased the number of applicants. However, the digitization of recruitment can alleviate this information overload by, for example, providing the Human Resourcer with an ordering of the applicants, based on their estimated suitability for a given position. For the NCIM-Group, a secondment company near Leidschendam, Learningto-Rank, a type of Machine Learning, was applied to automatically induce a way to do just this: to order a list of candidates based on a given job offer. The ranking model was learned from the company’s historical placement data. There are many ways of solving the learning-to-rank problem. Three stateof-the-art models, each one exemplifying one of the three common approaches, the pointpairand list-wise approach, have been implemented to identify which one is best suited for this problem. Specifically, a Gradient Boosted Regression Trees (GBRT) model (a point-wise method), a LambdaMART model (a pairwise method) and a SmoothRank model (a list-wise method) were applied. Their performance, plus a baseline Best-Single-Feature model, were compared with the existing Evolutionary Algorithm model on two common rank-based evaluation measures: Mean Average Precision (MAP) and mean Normalized Discounted Cumulative Gain (NDCG). All three methods improved the performance significantly compared to the existing algorithm, with an increase in MAP score up to 59.7% (GBRT-model vs. Evo.-model, p = 0.0001). Additional results indicate that adding Manifold Regularization, a semisupervised technique, to SmoothRank may improve its performance slightly by 6% (although not statistically significant).
Comparative Life Cycle Assessment of Rapeseed Oil and Biodiesel from Winter Rape Produced in Romania

The environmental performance of rapeseed oil (RO) and rapeseed methyl ester (RME) from winter rape as fuels produced in Romanian agroclimate is analyzed in this paper. The proposed methodology is life cycle assessment (LCA) and takes into consideration the influence of grain production and agroclimatic conditions. This study shows favorable results first for RO and then for RME. When compared to diesel fuel, both studied biofuels show better results in the following impact categories: Abiotic depletion potential (ADP), Ozone layer depletion (ODP) and Photochemical ozone creation potential (POCP). Furthermore, the environmental performance of the two biofuels studied can be improved by changing the type of fertilizer used and also by using biofuels instead of diesel in the field works. Keywords—Biodiesel, life cycle assessment, rapeseed oil.
RAD51 and XRCC3 Gene Polymorphisms and the Risk of Developing Acute Myeloid Leukemia

RAD51 (Rec A homolog of E.coli) is a polymorphic gene and one of the central proteins in homologous recombination-DNA-double-stand breaks (HR-DNA-DSB) repair pathway, which is vital in maintaining genetic stability within a cell. The x-ray repair cross complementing (XRCC3) protein also functions in HR-DNA-DSB repair pathway and directly interacts with and stabilizes RAD51 and the closely related RAD51C. The aim of this study was to determine the prevalence of the RAD51 and XRCC3 repair gene polymorphisms among acute myeloid leukemia (AML) patients and to define their role in development of AML and its correlation with the clinical presentation, laboratory data as well as treatment outcome using polymerase chain reaction-restriction fragment length polymorphism assay in 50 de novo AML patients as well as 30 healthy subjects as a control group. Our study revealed that RAD51 G135C and XRCC3 Thr241Met alleles were associated with increased risk of AML with odds ratio (OR) of 2.833 and 2.909 and 95% confidence interval (CI) of 1.527 to 8.983 and 1.761 to 9.788, respectively. Moreover, when combining the 2 genes polymorphisms, a significant elevation of the risk of AML was found with OR of 3.124 and 95% CI of 1.872 to 11.243. As regards treatment outcome, a highly statistical significant difference was found between XRCC3 genotypes with P value of 0.001, whereas no significant difference was present between RAD51 genotypes with P value of 0.29. This clarifies that XRCC3 gene polymorphisms was found to have a significant impact on the risk of treatment failure with OR of 3.560 and 95% CI of 1.167 to 10.875; however, RAD51 gene polymorphism was not found to have an equivalent effect with OR of 2.813 and 95% CI of 0.933 to 10.828. So XRCC3 gene polymorphism might be considered as a prognostic marker in AML. In conclusion, RAD51 and XRCC3 genes polymorphisms may play an important role in the development of AML.
Influence of stressors on breast cancer incidence in the Women's Health Initiative.

OBJECTIVE To examine associations among life events stress, social support, and breast cancer incidence in a cohort of postmenopausal women. DESIGN AND MAIN OUTCOME MEASURE: Women's Health Initiative observational study participants, breast cancer free at entry, who provided assessment of stressful life events, social support, and breast cancer risk factors, were prospectively followed for breast cancer incidence (n = 84,334). RESULTS During an average of 7.6 years of follow-up, 2,481 invasive breast cancers were diagnosed. In age-adjusted proportional hazards models, 1 stressful life event was associated with increased risk, but risk decreased with each additional stressful life event. After adjustment for confounders the decreasing risk was not significant. Stressful life events and social support appeared to interact in relation to breast cancer risk such that women who had greater number of stressful life events and low social support had a decreased risk of breast cancer. CONCLUSIONS This study found no independent association between stressful life events and breast cancer risk. The results are compatible with a more complex model of psychosocial factors interacting in relation to breast cancer risk.
Onlay versus Sublay Mesh Repair for Ventral Hernia

Introduction: Ventral hernia repair is among the most common surgical operations performed worldwide and the two operative techniques most frequently used in case of ventral hernia are the onlay and sublay repair. However, it remains unclear which technique is superior. The aim of this study was to compare the outcome of the onlay versus sublay mesh repair for ventral hernia. Patients and Methods: A total of 200 patients with paraumbilical, epigastric and supraumbilical incisional hernias were divided into main two groups; A; onlay mesh repair and B; sublay mesh repair. End Points:The primary end point of the study was recurrence of the hernia, defined as a clinically detectable characteristic swelling and diagnosed by the two authors. The secondary end points were operative time, drainage time, seroma formation and purulent wound infection. Results: The mean operative time for onlay repair was 67.04 ± 13.19 minutes while in sublay group was 93.26 ± 24.94 minutes ranged from 60 to 140 minutes. As regard the drainage time, the mean total time in days was 7.47 ± 1.7 days in onlay repair while in sublay group was 4.5 ± 1.1 days. Seroma formation after suction drain removal was observed in 6% patients in group A and in 2% in group B. Purulent wound infection was observed in 8% and 4% patients in group A and B respectively treated with dressing and proper antibiotic according to culture tests. Disease recurrence was observed in 8 % and 3 % patients of group A and B respectively. Conclusion: Sublay mesh repair is a good alternative to onlay mesh repair that may be applicable to all forms of ventral hernia. The mesh related overall complication rate is low such as drainage time, seroma formation and wound infection as well as the low recurrence rate. The authors concluded for trials on sublay mesh repair with a large number of cases and a longer period of follow-up.
Anti-Influenza Serum and Mucosal Antibody Responses After Administration of Live Attenuated or Inactivated Influenza Vaccines to HIV-Infected Children

Background:Live-attenuated influenza vaccine (LAIV) prevents more cases of influenza in immune-competent children than the trivalent inactivated vaccine (TIV). We compared the antibody responses to LAIV or TIV in HIV-infected children. Methods:Blood and saliva obtained at enrollment, 4 and 24 weeks postimmunization from 243 HIV-infected children randomly assigned to TIV or LAIV were analyzed. Results:Both vaccines increased the anti-influenza neutralizing antibodies at 4 and 24 weeks postimmunization. At 4 weeks postimmunization, TIV recipients had 2-fold to 3-fold higher neutralizing antibody titers than LAIV recipients, but the proportions of subjects with protective titers (≥1:40) were similar between treatment groups (96%-100% for influenza A and 81%-88% for influenza B). Both vaccines increased salivary homotypic IgG antibodies, but not IgA antibodies. Both vaccines also increased serum heterosubtypic antibodies. Among HIV-specific characteristics, the baseline viral load correlated best with the antibody responses to either vaccine. We used LAIV-virus shedding as a surrogate of influenza infection. Influenza-specific humoral and mucosal antibody levels were significantly higher in nonshedders than in shedders. Conclusions:LAIV and TIV generated homotypic and heterosubtypic humoral and mucosal antibody responses in HIV-infected children. High titers of humoral or mucosal antibodies correlated with protection against viral shedding.
Limited prognostic value of tissue protein expression levels of BCl‐2 in Danish ovarian cancer patients: from the Danish ‘MALOVA’ ovarian cancer study

Høgdall EVS, Christensen L, Kjaer SK, Blaakaer J, Christensen IJ, Høgdall CK. Limited prognostic value of tissue protein expression levels of BCl‐2 in Danish ovarian cancer patients. APMIS 2010; 118: 557–64.
Diagnosis of infections caused by Enterocytozoon bieneusi and Encephalitozoon intestinalis using polymerase chain reaction in stool specimens

Objective:To study the usefulness of polymerase chain reaction (PCR) for the species identification of microsporidia in stool specimens obtained from HIV- infected patients with Enterocytozoon bieneusi or Encephalitozoon intestinalis infections. Setting:Infectious disease clinic in a university hospital. Patients:Thirty-seven stool specimens from 29 HIV-infected patients with microsporidiosis were tested. The diagnosis of microsporidian infection was made by light microscopy of stool specimens and species identification was made by transmission electron microscopy of duodenal biopsies. Sixty-one stool specimens from 45 HIV-infected patients without microsporidiosis served as controls. Methods:PCR was performed using DNA extracted from stools with two primers sets, one specific for E. bieneusiand one specific for E. intestinalis. Results:A 1265 base-pair fragment of the small subunit ribosomal RNA (rrs) gene could be amplified from all 31 stool specimens infected with E. bieneusi. In addition, a 930 base-pair fragment of the rrs gene could be amplified from all six stool specimens infected with E. intestinalis. The 61 control stools were negative with both primers. Conclusions:These results suggest that a PCR-based assay using species-specific primers sets can be used successfully for microsporidian species differentiation from stool specimens, thus obviating the need for invasive biopsy procedures.
Gastrointestinal , Hepatobiliary and Pancreatic Pathology Human Intestinal Ischemia-Reperfusion – Induced Inflammation Characterized Experiences from a New Translational Model

Human intestinal ischemia-reperfusion (IR) is a frequent phenomenon carrying high morbidity and mortality. Although intestinal IR-induced inflammation has been studied extensively in animal models, human intestinal IR induced inflammatory responses remain to be characterized. Using a newly developed human intestinal IR model, we show that human small intestinal ischemia results in massive leakage of intracellular components from ischemically damaged cells, as indicated by increased arteriovenous concentration differences of intestinal fatty acid binding protein and soluble cytokeratin 18. IR-induced intestinal barrier integrity loss resulted in free exposure of the gut basal membrane (collagen IV staining) to intraluminal contents, which was accompanied by increased arteriovenous concentration differences of endotoxin. Western blot for complement activation product C3c and immunohistochemistry for activated C3 revealed complement activation after IR. In addition, intestinal IR resulted in enhanced tissue mRNA expression of IL-6, IL-8, and TNF, which was accompanied by IL-6 and IL-8 release into the circulation. Expression of intercellular adhesion molecule-1 was markedly increased during reperfusion, facilitating influx of neutrophils into IR-damaged villus tips. In conclusion, this study for the first time shows the sequelae of human intestinal IR-induced inflammation, which is characterized by complement activation, production and release of cytokines into the circulation, endothelial activation, and neutrophil influx into IRdamaged tissue. (Am J Pathol 2010, 176:2283–2291; DOI: 10.2353/ajpath.2010.091069)
Hereditarily finite Finsler sets

Hereditarily finite sets are sets which are finite, whose members are finite, the members of whose members are finite, and so on. In ZF there are but countably many such sets; they constitute Vω. Were ZF to lose its axiom of regularity, however, one could not guarantee that the number of hereditarily finite sets would remain countable. In Mostowski set theory, in which atomic sets are permissible, each atom, in isolation, would form a hereditarily finite collection. The number of hereditarily finite sets could be anything one should choose. Even in a world that did not permit the free adjunction of arbitrary, meaningless atoms, the number of hereditarily finite sets could remain large. In Finsler set theory, it is shown as Theorem 22, below, that there are uncountably many hereditarily finite sets. The reader who is interested in this paradoxical sounding fact can turn directly to §4 after grasping these introductory concepts. §3 is an exhaustive list of the smallest Finsler sets; it is hoped that this list will prove useful in checking future attempts to classify the finite Finsler sets. Finsler set theory is not a firmly axiomatized theory. It is, at its present stage, a family of theories undergoing evolution. It permits the usual mathematical operations with sets. One can employ ordinal numbers, cardinal numbers, and the usual methods of Cantorian set theory freely. But there is a somewhat different interpretation attached to the concept “set” than one is used to in Zermelo-Fraenkel set theory, ZF.
Articular cartilage: a review and scanning electron microscope study. II. The territorial fibrillar architecture.

Until comparatively recently, the Transmission Electron Microscope (TEM) was the only tool available for studying the finer morphology of the fibrillar structures in articular cartilage. With the advent of the Scanning Electron Microscope (SEM) (McCall, 1968) many more research possibilities have been opened up in this field (Gardner & Woodward, 1969; Inoue, Kodama & Fujita, 1969; Okuda, 1970; Ohnsorge, Schutt & Holm, 1970; Evans & Clarke, 1971; Puhl, Dustmann & Schulitz, 1971; Highton, 1971; Zimny & Redler, 1972). However, it is unfortunate that much of the SEM data has not been integrated with that obtained previously by TEM and light microscopy. Only by such critical reviewing can we begin to discriminate between artefacts and real structures (Clarke, 1971 a). The main objective in this present study of the pericellular fibrillar structures in articular cartilage was to compare the SEM data with those derived from TEM studies.
Comparison of pelvic floor muscle training, electromyography biofeedback, and neuromuscular electrical stimulation for bladder dysfunction in people with multiple sclerosis: A randomized pilot study

Bladder dysfunction affects up to 90% of the multiple sclerosis (MS) population. Interventions such as Pelvic Floor Training and Advice (PFTA), Electromyography (EMG) Biofeedback, and Neuromuscular Electrical Stimulation (NMES) have received limited research attention within this population. This study aimed to determine the effectiveness of a combined programme of PFTA, EMG Biofeedback, and NMES for bladder dysfunction in MS.
High-sensitivity brain SPECT system using cadmium telluride (CdTe) semiconductor detector and 4-pixel matched collimator

For high-sensitivity brain imaging, we have developed a two-head single-photon emission computed tomography (SPECT) system using a CdTe semiconductor detector and 4-pixel matched collimator (4-PMC). The term, ‘4-PMC’ indicates that the collimator hole size is matched to a 2 × 2 array of detector pixels. By contrast, a 1-pixel matched collimator (1-PMC) is defined as a collimator whose hole size is matched to one detector pixel. The performance of the higher-sensitivity 4-PMC was experimentally compared with that of the 1-PMC. The sensitivities of the 1-PMC and 4-PMC were 70 cps/MBq/head and 220 cps/MBq/head, respectively. The SPECT system using the 4-PMC provides superior image resolution in cold and hot rods phantom with the same activity and scan time to that of the 1-PMC. In addition, with half the usual scan time the 4-PMC provides comparable image quality to that of the 1-PMC. Furthermore, 99mTc-ECD brain perfusion images of healthy volunteers obtained using the 4-PMC demonstrated acceptable image quality for clinical diagnosis. In conclusion, our CdTe SPECT system equipped with the higher-sensitivity 4-PMC can provide better spatial resolution than the 1-PMC either in half the imaging time with the same administered activity, or alternatively, in the same imaging time with half the activity.
Gemcitabine inhibits the micrometastasis of non-small cell lung cancer by targeting the EpCAM-positive circulating tumor cells via the HGF/cMET pathway.

Recurrence and metastasis are responsible for the death of non-small cell lung cancer (NSCLC) patients. Circulating tumor cells (CTCs) in the metastatic pathway have proven to be essential. This pilot study evaluated the sensitivity of gemcitabine in micrometastasis and CTCs from NSCLC patients. EpCAM-positive CTCs were detected in forty patients with NSCLC at treatment initiation and disease evaluation time-points. EpCAM-positive CTCs were defined as EpCAM-positive and CD45-negative. Total RNA was isolated from EpCAM-enriched CTCs and cytokeratin levels were detected by PCR. The HGF/cMET pathway was evaluated in CTCs from patients with different treatments and in A549 cells. The EMT-related markers were analyzed by IHC. We further explored the predictive value of baseline CTCs in patients that were receiving different treatments. The median number of CTCs in NSCLC patients was 65 CTCs/ml more than in the healthy 23? fold (median, 5.2 CTCs/ml). The mean change in cell count was significantly different for patients with gemcitabine compared to patients with non-gemcitabine treatments (-86.28 vs. -15.23/ml; P<0.05). A significant decrease was noted in the expression of cytokeratin in the CTCs of the two groups (P<0.05). The HGF/cMET pathway was inactivated in CTCs and A549 cells treated with gemcitabine, and the cell migration and invasion abilities were inhibited by gemcitabine via the HGF/cMET pathway. Furthermore, the decreased cell migration and invasion abilities may also be involved in the inhibition of the epithelial-mesenchymal transition (EMT) by gemcitabine. At a median follow-up of 36 months, the CTC count was confirmed to be a robust prognostic marker in the NSCLC population (CTCs >151, median: 15.0 months and CTCs <151, median: 32.0 months). Additionally, the survival rate in the gemcitabine group (24 months) was better than in non-gemcitabine group (21 months), suggesting a therapeutic benefit for NSCLC patient survival with the common therapy plus gemcitabine. Gemcitabine treatment decreased EpCAM-positive CTCs in NSCLC patients and inhibited EMT by the HGF/cMET pathway.
Challenging construction project management institutions: the role and agency of BIM actors

Abstract The use of building information modelling (BIM) has opened up for new roles. Previous studies on BIM roles focused on their duties, formal responsibilities and legitimacy, but few studies pay attention to how BIM actors (BIM coordinators and strategists) act to support increased BIM usage. Applying the theoretical construct of institutional work, this paper aims to create an understanding of the role and agency of BIM actors. Based on observations and semi-structured interviews with BIM actors and managers, the findings show: (1) purposive actions of BIM actors to promote and diffuse new BIM practices; (2) tensions between creating new BIM practices and maintaining existing construction management institutions; (3) BIM actor as an interface between the BIM technology and its users. Focusing on the BIM actor’s role and agency gives insights into the hard process of changing and/or disrupting traditional construction management institutions and creating new practices arising from increased digitalization.
Interrelationships of protein and DNA syntheses during replication of mammalian cells

During the replication of chromatin, the syntheses of the histone protein and DNA components are closely coordinated but not totally linked. The interrelationships of total protein synthesis, histone protein synthesis, DNA synthesis, and mRNA levels have been investigated in Chinese hamster ovary cells subjected to several different types of inhibitors in several different temporal combinations. The results from these studies and results reported elsewhere can be brought together into a consistent framework which combines the idea of autoregulation of histone biosynthesis as originally proposed by W. B. Butler and G. C. Mueller (Biochim. Biophys. Acta 294:481-496, 1973] with the presence of basal histone synthesis and the effects of protein synthesis on DNA synthesis. The proposed framework obviates the difficulties of Butler and Mueller's model and may have wider application in understanding the control of cell growth.
Path following for a car-like robot using transverse feedback linearization and tangential dynamic extension

This article proposes a path following controller for the two input kinematic model of a car-like robot. A smooth dynamic feedback control law is designed to make the car's position follow a large class of curves with the desired speed along the curve. The controller guarantees the property of path invariance. The controller is designed by characterizing the path following manifold when one input is fixed. Once the path following manifold is found we apply dynamic extension to increase its dimension. We refer to this process as tangential dynamic extension. We then find a physically meaningful differentially flat output for the extended system which allows us to easily solve the path following problem.