Miracle-dz/UniFAR-FTUs huggingface dataset:
Loss of follow-up in transition to adult CHD: a single-centre experience

Abstract Lapses in care during transition in adult CHD patients lead to increased morbidity and mortality. Previous studies have investigated predictors of poor follow-up in universal healthcare paradigms and select American populations. We studied patients with a wide spectrum of CHD severity within a single American centre to identify factors associated with successful internal transition and maintenance of care. Loss of follow-up was defined as no documented cardiac follow-up for ⩾3 years. Ambulatory cardiology patients aged 16–17 years with CHD were retrospectively enrolled and contacted. A survey assessing demographics, patients’ understanding of their CHD, medical status, and barriers to care was administered. On the basis of chart review of 197 enrolled patients, 74 demonstrated loss of follow-up (37.6%). Of 78 successfully contacted patients, 58 were surveyed, of whom a minority had loss of follow-up (n=16). The status of most patients with loss of follow-up was not known. Maintenance of care was associated with greater complexity of CHD (p<0.01), establishment of care with an adult CHD provider (p<0.001), use of prescription medications (p<0.001), and receipt of education emphasising the importance of long-term cardiac care (p<0.003). Insurance lapses were not associated with loss of follow-up (p=0.08). Transition and maintenance of care was suboptimal even within a single centre. Over one-third of patients did not maintain care. Patients with greater-complexity CHD, need for medications, receipt of transition education, and care provided by adult CHD providers had superior follow-up.
Object detection in sports videos

Object detection is commonly used in many computer vision applications. In our case, we need to apply the object detector as a prerequisite for action recognition in handball scenes. Object detection, to be successful for this task, should be as accurate as possible and should be able to deal with a different number of objects of various sizes, partially occluded, with bad illumination and deal with cluttered scenes. The aim of this paper is to provide an overview of the current state-of-the-art detection methods that rely on convolutional neural networks (CNNs) and test their performance on custom video sports materials acquired during handball training and matches. The comparison of the detector performance in different conditions will be given and discussed.
Ethological observations of social behavior in the operating room

Significance Hierarchy and gender composition affect the balance of cooperation and conflict on surgical teams. In this investigation, behavior was quantified with methods traditionally used to study nonhuman primate groups. Observers used an ethogram to timestamp 6,348 spontaneous social interactions from 200 surgical procedures. Conflict and cooperation in the operating room showed a significant interaction effect with regard to professional roles (e.g., conflict was initiated mostly down the hierarchy between individuals several ranks apart) and by gender interaction (e.g., cooperation was better if the attending surgeon’s gender differed from that of the team majority). These findings may inform ongoing and future interventions designed to improve team performance and patient safety. Operating rooms (ORs) are inhabited by hierarchical, mixed-gender clinical teams that are often prone to conflict. In evolutionary terms, one expects more within- than between-gender rivalries, especially since the OR is a place where all sorts of social interactions occur, not merely technical communications. To document the full range of behavior, the present study used ethological observation techniques, recording live all social behavior by the team. Using an ethogram, 6,348 spontaneous social interactions and nontechnical communications were timestamped during 200 surgical procedures. Cooperation sequences (59.0%) were more frequent than conflict sequences (2.8%), which ranged from constructive differences of opinion to discord and distraction that could jeopardize patient safety. Behavior varied by clinical role and with the gender composition in the OR. Conflict was initiated mostly down the hierarchy between individuals several ranks apart. Cooperation tended to increase with a rising proportion of females in the OR, but the most pronounced effect concerned the interaction between both genders. If the attending surgeon’s gender differed from that of the majority of other personnel in the OR, cooperation was significantly more common.
A Potential Golden Age to Come—Current Tools, Recent Use Cases, and Future Avenues for De Novo Sequencing in Proteomics

In shotgun proteomics, peptide and protein identification is most commonly conducted using database search engines, the method of choice when reference protein sequences are available. Despite its widespread use the database‐driven approach is limited, mainly because of its static search space. In contrast, de novo sequencing derives peptide sequence information in an unbiased manner, using only the fragment ion information from the tandem mass spectra. In recent years, with the improvements in MS instrumentation, various new methods have been proposed for de novo sequencing. This review article provides an overview of existing de novo sequencing algorithms and software tools ranging from peptide sequencing to sequence‐to‐protein mapping. Various use cases are described for which de novo sequencing was successfully applied. Finally, limitations of current methods are highlighted and new directions are discussed for a wider acceptance of de novo sequencing in the community.
Using the Memory Validity Profile (MVP) to detect invalid performance in youth with mild traumatic brain injury

Abstract Performance validity tests (PVT) should be used when assessing youth with mild traumatic brain injury (MTBI). The goal of this study was to derive a new cutscore for determining invalid performance on the Memory Validity Profile (MVP) in youth with MTBI. Children and adolescents (N = 92; mean age =14.8 years, SD = 2.3, range =8–18) on average six months (SD = 3.6) post-MTBI were administered the MVP as part of their assessment. Two validated PVTs [Test of Memory Malingering (TOMM) and Medical Symptom Validity Test (MSVT)] were administered and used to group the sample into valid (n = 73, neither TOMM/MSVT failed) and invalid (n = 19, both TOMM/MSVT failed). New cutscores for the MVP to determine invalid performance in this sample were established using failure on both TOMM/MSVT as the criterion. MVP performance correlated significantly with failure on TOMM/MSVT. Youth with invalid performance had significantly lower MVP total scores and area under the curve was . 80, suggesting good separation of groups. A cutscore of 31 or less on the MVP provided sensitivity of 63% for detecting invalid performance with 93% specificity. This study yields a promising new cutscore for the MVP that has good sensitivity and strong specificity for detecting invalid performance in youth with MTBI.
Ergosterol and its derivatives from Grifola frondosa inhibit antigen-induced degranulation of RBL-2H3 cells by suppressing the aggregation of high affinity IgE receptors

ABSTRACT Grifola frondosa is an edible mushroom consumed as a health food and/or traditional medicine in Asia. However, the anti-allergic effects of G. frondosa are not yet understood. In this study, we demonstrated the effects of G. frondosa extract (GFE) on IgE-mediated allergic responses, using antigen-stimulated RBL-2H3 cells. Three active compounds: ergosterol, 6β-methoxyergosta-7,22-dien-3β,5α-diol (MEDD), and 6-oxoergosta-7,22-dien-3β-ol (6-OXO) were isolated from GFE and shown to inhibit the antigen-induced release of β-hexosaminidase and histamine. Among the three active components, we focused on ergosterol because of its high content in GFE. Ergosterol inhibited the aggregation of high-affinity IgE receptor (FcεRI), which is the first step in the activation of mast cells and antigen-induced tyrosine phosphorylation. Furthermore, ergosterol suppressed antigen-increased IL-4 and TNF-α mRNA. Taken together, our findings suggest that G. frondosa, including ergosterol and its derivatives as active components, has the potential to be a novel functional food that prevents type I allergies. Graphical Abstract
Redundancy in synaptic connections enables neurons to learn optimally

Significance Humans and animals are capable of rapid learning from a small dataset, which is still difficult for artificial neural networks. Recent studies further suggest that our learning speed is nearly optimal given a stream of information, but its underlying mechanism remains elusive. Here, we hypothesized that the elaborate connection structure between presynaptic axons and postsynaptic dendrites is the key element for this near-optimal learning and derived a data-efficient rule for dendritic synaptic plasticity and rewiring from Bayesian theory. We implemented this rule in a detailed neuron model of visual perceptual learning and found that the model well reproduces various known properties of dendritic plasticity and synaptic organization in cortical neurons. Recent experimental studies suggest that, in cortical microcircuits of the mammalian brain, the majority of neuron-to-neuron connections are realized by multiple synapses. However, it is not known whether such redundant synaptic connections provide any functional benefit. Here, we show that redundant synaptic connections enable near-optimal learning in cooperation with synaptic rewiring. By constructing a simple dendritic neuron model, we demonstrate that with multisynaptic connections synaptic plasticity approximates a sample-based Bayesian filtering algorithm known as particle filtering, and wiring plasticity implements its resampling process. Extending the proposed framework to a detailed single-neuron model of perceptual learning in the primary visual cortex, we show that the model accounts for many experimental observations. In particular, the proposed model reproduces the dendritic position dependence of spike-timing-dependent plasticity and the functional synaptic organization on the dendritic tree based on the stimulus selectivity of presynaptic neurons. Our study provides a conceptual framework for synaptic plasticity and rewiring.
Pilot evaluation of a web-based acceptance and commitment therapy program to promote mental health skills in university students.

OBJECTIVE This study evaluated a 4-week web-based acceptance and commitment therapy (ACT) mental health promotion program called YOLO (You Only Live Once) for university students. METHOD A total of 130 participants were randomized to one of three intervention groups investigating varied program delivery methods. Primary outcomes assessed: depression, anxiety, stress, well-being, self-compassion, alcohol use, and life satisfaction. ACT processes assessed: acceptance, cognitive fusion, education values, valued living, and mindfulness. RESULTS Improvement on the primary outcomes and ACT processes did not differ among the three intervention groups. Analyses showed significant improvements on all primary outcomes (except alcohol use), and on all ACT processes. All ACT processes mediated changes on one or more primary outcomes in the intent-to-treat sample. Intervention effects were consistent on most primary outcomes and ACT processes across three sample groupings. CONCLUSIONS These preliminary findings provide support for a web-based ACT mental health promotion program for university students.
RESOLUTION, DEPTH OF FIELD, AND PHYSICIAN SATISFACTION DURING DIGITALLY ASSISTED VITREORETINAL SURGERY.

PURPOSE To evaluate depth of field, lateral resolution, and image quality of a heads-up 3D visualization system for vitreoretinal surgery using physician survey and optical measurement outcomes. METHODS Depth of field and lateral resolution were compared between the standard ocular viewing system and the digital 3D system at ×5, ×13, and ×18 magnification by 6 retinal surgeons. Optical techniques were used as well as a survey of surgeon impression. Surgeon impression surveys were performed after 6 weeks of surgical use of the device. RESULTS Physician questionnaire survey scores for depth of field at high magnification were better for the digital 3D system and equivalent for all other categories. Measured lateral resolution was 36.7 mm and 16.6 mm at ×5 magnification (P < 0.001), 14.3 mm and 6.4 mm at ×13 magnification (P < 0.001), and 9.8 mm and 4.2 mm (P < 0.001) at ×18 magnification for the digital 3D and oculars, respectively. Measured depth of field was 4.00 mm and 6.78 mm at ×5 magnification (P = 0.027), 0.72 mm and 0.86 mm at ×13 (P = 0.311), and 0.28 mm and 0.40 mm at ×18 magnification (P = 0.235) for the oculars and digital 3D, respectively. CONCLUSION Lateral resolution of the digital 3D system was half that of the ocular viewing system and there was some improvement in depth of field with the digital system. Surgeon impression suggested that the digital system was superior when evaluating depth of field at high magnification.
Comparative analysis of blockchain consensus algorithms

Cryptocurrencies have seen a massive surge in popularity and behind these new virtual currencies is an innovative technology called the blockchain: a distributed digital ledger in which cryptocurrency transactions are recorded after having been verified. The transactions within a ledger are verified by multiple clients or “validators,” within the cryptocurrency's peer-to-peer network using one of many varied consensus algorithms for resolving the problem of reliability in a network involving multiple unreliable nodes. The most widely used consensus algorithms are the Proof of Work (PoW) algorithm and the Proof of Stake (PoS) algorithm; however, there are also other consensus algorithms which utilize alternative implementations of PoW and PoS, as well as other hybrid implementations and some altogether new consensus strategies. In this paper, we perform a comparative analysis of typical consensus algorithms and some of their contemporaries that are currently in use in modern blockchains. Our analysis focuses on the algorithmic steps taken by each consensus algorithm, the scalability of the algorithm, the method the algorithm rewards validators for their time spent verifying blocks, and the security risks present within the algorithm. Finally, we present our conclusion and some possible future trends for consensus algorithms used in blockchains.
Macroscopic and Microscopic Properties of Some Surfactants and Biosurfactants

The adsorption of surfactants at the water-air and solid-water interfaces and their wetting properties decide their practical applications. Therefore the adsorption of monorhamnolipid, surfactin, n-octyl-β-d-glucopyranoside, n-dodecyl-β-d-glucopyranoside, n-dodecyl-β-d-maltoside, sucrose monodecanoate, sucrose monododecanoate, Tween 20, Tween 60, and Tween 80 at the water-air, polytetrafluoroethylene-water, polyethylene-water, poly(methyl methacrylate)-water, polyamide-water, and quartz-water interfaces, their tendency to form micelles as well as their wetting properties, were considered in the light of their microscopic properties. For this purpose, the components and parameters of the surfactant tail and head, water and solids surface tension, and surfactant contactable area with adherent medium were applied for prediction of surfactant-surfactant and surfactant-solid interactions through the water phase with regard to their adsorption, micellization, and wetting processes. Next, the Gibbs free energy of interactions was compared to the Gibbs free energy of surfactant adsorption at the water-air and solid-water interfaces as well as the micellization. It appeared that from the surfactant-surfactant and surfactant-solid interactions through the water phase determined on the basis of the tail and head of surfactant surface tension, it is possible to predict the surfactant tendency to adsorb at the water-air and solid-water interfaces, as well as to form micelles.
Rural-Urban Differences in Human Immunodeficiency Virus Testing Among US Adults: Findings From the Behavioral Risk Factor Surveillance System

Individuals in rural areas of the United States face barriers to human immunodeficiency virus (HIV)-related health care. We aim to assess differences in frequency of lifetime and past-year HIV testing, and differences in testing site location between rural and urban residents of the United States. Methods Data from the Behavioral Risk Factor Surveillance System 2015 were analyzed on 250,579 respondents 18 years or older. Weighted multinomial logistic regression analyses compared urban/rural differences in lifetime and past-year HIV testing. Weighted multinomial logistic regression compared urban/rural differences in HIV testing site. Results Overall, 26.9% of urban residents and 21.5% of rural residents reported testing for HIV in their lifetime. Of urban residents, 24.5% reported receiving an HIV test in the past year compared with 20.2% of rural residents. Living in a rural area was associated with lower odds of lifetime (odds ratio [OR], 0.85; 95% confidence interval [CI], 0.81–0.90) and past-year HIV testing (OR, 0.84; 95% CI, 0.74–0.95) compared with not testing. Rural residents had higher odds of receiving an HIV test at the hospital or emergency room (adjusted OR, 1.41; 95% CI, 1.23–1.62) or clinic (adjusted OR, 1.21; 95% CI, 1.02–1.24) than a doctor's office. Conclusions This study highlights significant rural health disparities in rates of lifetime and past-year HIV testing. Targeted interventions are needed to remove structural barriers in rural communities, such as long distances to clinics and low availability of free HIV testing at clinics serving the uninsured or underinsured. Furthermore, rural providers should be encouraged to routinely offer HIV screening to their patients.
Autologous transplantation improves survival rates for follicular lymphoma patients who relapse within two years of chemoimmunotherapy: a multi-center retrospective analysis of consecutively treated patients in the real world

Abstract Although chemoimmunotherapy improves outcomes for patients with follicular lymphoma (FL), approximately 20% of patients experience early disease progression within two years of treatment and subsequently poor median survival. We conducted a retrospective study to evaluate survival rates of patients with early relapse who were treated with or without autologous transplantation. Of 517 patients with FL and who received chemoimmunotherapy, 152 relapsed and survived a minimum of four months after progression, including 84 (55.3%) with early relapse ≤2 years following initial therapy and 68 (44.7%) with later relapse. Five-year survival was superior for patients who received autologous transplantation compared to non-transplanted patients within the early relapse group (85.4% vs 57.9%, p = .001), but not within the late relapse group (p = .64). Given the limitations of a retrospective study, our study may suggest that the use of autologous transplantation for FL patients who relapse within two years of initial chemoimmunotherapy is associated with improved survival.
High Neutrophil-to-Lymphocyte Ratio Predicts Stroke-Associated Pneumonia

Background and Purpose— Although there are a variety of risk factors and predictive models for stroke-associated pneumonia (SAP), more objective and easily accessible markers are still needed. In this study, we evaluated the relationship between the neutrophil-to-lymphocyte ratio (NLR) and SAP in patients with acute ischemic stroke. Methods— We assessed 1317 consecutive patients with acute ischemic stroke. SAP was defined according to the modified Centers for Disease Control and Prevention criteria. The severity of pneumonia was rated using scores from the Pneumonia Severity Index, the quick Sequential Organ Failure Assessment, and the Acute Physiology and Chronic Health Evaluation II. The NLR was calculated after dividing absolute neutrophil counts by absolute lymphocyte counts. Results— Among the total patients, SAP occurred in 112 (9.0%) patients. Using a multivariable analysis, the NLR (adjusted odds ratio=1.55; 95% confidence interval, 1.15–2.11; P=0.005) remained significant after adjusting for confounders. In addition, age, atrial fibrillation, previous stroke history, initial National Institutes of Health Stroke Scale score, and high-sensitivity C-reactive protein were also significant, independent of NLR. The NLR was higher in the severe pneumonia group when it was assessed by Pneumonia Severity Index (P<0.001), quick Sequential Organ Failure Assessment (P<0.001), and Acute Physiology and Chronic Health Evaluation II scores (P=0.004). Furthermore, patients who had SAP had worse clinical outcomes both during hospitalization and after discharge. Conclusions— We demonstrated that a higher NLR predicted SAP in patients with acute ischemic stroke. The NLR may help to identify high-risk patients in time and provide clues for further studies about preventive antibiotic therapy.
Changes in Couple Relationship Dynamics among Low-Income Parents in a Relationship Education Program Are Associated with Decreases in Their Children’s Mental Health Symptoms

Witnessing intimate partner violence (IPV) among parents negatively impacts millions of children in the United States each year. Low-income families are disproportionately affected by IPV compared to middle- and high-income individuals, and are beginning to be the focus of IPV secondary prevention interventions, including relationship education programs. Despite these developments, few studies have examined changes in psychosocial functioning among children of parents participating in relationship education programs. The current study examined the extent to which changes in specific couple dynamics among individuals from low-income backgrounds participating in a couple relationship education program, Within My Reach, were associated with changes in child mental health symptoms. A second purpose of this paper is to examine whether changes in parent⁻child relationship quality mediates the association between changes in couple dynamics and changes in child mental health difficulties. Participants (n = 347) were parents who participated in Within My Reach as part of programming offered at a large community agency. Decreases in negative couple conflict behaviors, including conflict engagement, withdrawal and compliance, over the course of the program were linked to decreases in child mental health difficulties. In addition, increases in parent⁻child relationship quality partially mediated the associations between decreases in compliance, as well as increase in overall couple relationship quality, and decreases in child symptoms. Community-based couple relationship education programs for low-income families can potentially have multiple positive impacts throughout the family system, including for children.