Miracle-dz/UniFAR-FTUs huggingface dataset:
Kinetic Modeling of Incremental Ambulatory Peritoneal Dialysis Exchanges

♦ Background: Incremental peritoneal dialysis (PD), the gradual introduction of dialysate exchanges at less than full-dose therapy, has been infrequently described in clinical reports. One concern with less than full-dose dialysis is whether urea clearance targets are achievable with an incremental regimen. In this report, we used a large database of PD patients, across all membrane transport types, and performed urea kinetic modeling determinations of possible incremental regimens for an individual membrane type. ♦ Methods: Using a modified 3-pore model of peritoneal transport, various incremental manual continuous ambulatory PD (CAPD) exchanges employing glucose and/or icodextrin were evaluated. Peritoneal urea clearances from those simulations were added to residual kidney urea clearance for patients with various glomerular filtration rates (GFRs), and the total weekly urea clearance was then compared to the total weekly urea Kt/V target of 1.7. All 4 peritoneal membrane types were modeled. For each simulated prescription, net ultrafiltration and carbohydrate absorption were also calculated. ♦ Results: Incremental CAPD regimens of 2 exchanges a day met adequacy targets if the GFR was 6 mL/min/1.73 m2 in all membrane types. For regimens employing 3 exchanges a day, Kt/V targets were achieved at GFR levels of 4 to 5 mL/min/1.73 m2 in high transporters to low transporters but higher tonicity 2.5% glucose solutions or icodextrin were required in some regimens. ♦ Conclusions: This work demonstrates that with incremental CAPD regimens, urea kinetic targets are achievable in most new starts to PD with residual kidney function. Incremental PD may be a less intrusive, better accepted initial treatment regime and a cost-effective way to initiate chronic dialysis in the incident patient. The key role of intrinsic kidney function in incremental regimens is highlighted in this analysis and would warrant conscientious monitoring.
Psychometric properties of the dundee ready educational environment measure in a sample of Ghanaian Medical Students

Background: The Dundee Ready Educational Environment Measure (DREEM) has been widely accepted and recognized for the assessment of the educational environment in a variety of health professions education programs. Concerns regarding the psychometric properties of the DREEM have been raised. This study evaluated the psychometric properties of the DREEM in a sample of Ghanaian medical students following a problem-based learning curriculum. Methods: A sample of 234 second to fourth year medical students of the University for Development Studies, School of Medicine and Health Sciences were invited to complete the DREEM questionnaire. Psychometric measures employed included Cronbach's alpha analysis, confirmatory factor analysis and principal component analysis with varimax rotation. Results: The internal consistency for the overall DREEM was 0.92. Apart from two subscales that had Cronbach's alpha values < 0.70, the remainder had values ranging from 0.73 – 0.78. Confirmatory factor analysis did not support the original five factor structure of the DREEM. Large significant correlation coefficients were found between the five factors raising concerns about the independency of the individual subscales. Exploratory factor analysis suggested various factor solutions ranging from 4 to 14 factors. The four factor structure was interpretable and was maintained. All of the four factors achieved eigenvalues > 1, and in total they accounted for 37.6% of the variance. Alpha values for the subscales of the new four factor structure ranged from 0.618 – 0.915. Discussion: The overall internal consistency of the DREEM was found to be excellent. The internal consistency of the individual subscales was variable, as two subscales had alpha values < 0.70 and the remainder exceeding 0.70. The original five factor structure of the DREEM was not supported. Exploratory factor analysis suggested a four factor solution as a possible alternative to the five factor structure of the DREEM.
RNAi technology targeting Pb GP 43 and Pb P 27 in Paracoccidioides brasiliensis

Efficient technologies for gene silencing would be important to carry out functional analysis with P. brasiliensis genes, as well as for a better understanding of the biology and pathogenesis of this pathogenic fungus. Due to the fact that homologous recombination is unusual in P. brasiliensis, the development of knockout isolates is currently non-feasible. The goal of this work was to assess RNA interference (RNAi) technology as an alternative tool for gene silencing previously employed successfully in H. capsulatum. For this purpose, we built different inverted repeat transgenic hairpin constructs to down-regulate the PbGP43 and PbP27 genes known to codify for two fungal immunogenic proteins that elicit a strong immune response during experimental paracoccidioidomycosis. Using the RNAi strategy, a reduction in the mRNA levels of the PbGP43 and PbP27 genes was observed during the first 20 days after selection; however, in the transformed yeast cells, the gene silencing status proved non-stable through the assay. We demonstrated that electrotransformation was suitable to transform P. brasiliensis yeast cells and integrate the hairpin constructions; nonetheless, gene silencing was not stable along the experimental time. A detailed analysis of the underlying molecular RNAi machinery may provide further insights into the intracellular mechanism that governs this reverse genetic tool.
Determination of Rare Earth Elements (REEs) in Airborne Particulate Matter (APM) Collected in Tokyo, Japan, and a Positive Anomaly of Europium and Terbium

The determination of rare earth elements (REEs) in airborne particulate matter (APM) was conducted, and the distribution pattern of atmospheric REEs was evaluated in this study. The APM was collected in the center of Tokyo, Japan, where serious air pollution is always of concern. A cellulose acetate membrane filter was used to collect the APM because Ba and REEs contamination is lower than that in a quartz glass fiber filter. The REEs measurement was conducted by ICP-MS after the digestion of the APM by a microwave acid digestion procedure. The standard reference material (SRM) of NIST 1648 urban particulate matter was used to validate the accuracy of the analytical method. The analytical results for SRM well agreed with those of the reference and reported values. Consequently, the analytical method established in this study was applied to the determination of REEs in APM collected in Tokyo, Japan. The obtained REEs distribution pattern in the APM showed a positive anomaly of Tb and Eu. The La/Sm ratio, which is considered to be as a good indicator of the anthropogenic effect, in size-classified APM showed a high degree of the anthropogenic effect in fine APM with a diameter of <1.1 μm. Emission sources of Tb, Eu and other REEs are discussed.
Relationship of Body Mass Index With Asthma Indicators in Head Start Children

Vargas P, Perry T, Robles E, et al. Ann Allergy Asthma Immunol. 2007;99(1):22–28 PURPOSE OF THE STUDY. To examine the relationship of BMI and asthma in children in the Head Start program in Arkansas. STUDY POPULATION. A group of 213 children aged 3 to 5 years with physician-diagnosed asthma were compared with 816 age-matched peer control subjects from the sample of the National Health and Nutrition Examination Survey (NHANES) and with 1024 children in prekindergarten in Arkansas public schools. METHODS. Caregivers of the children with asthma from the Head Start program were interviewed with a structured questionnaire including the Juniper Asthma Quality of Life Survey, and the children's medical charts were reviewed. One hundred forty-one of the 213 children underwent skin-prick testing. One hundred forty-five of the children had urine cotinine levels measured to determine exposure to environmental tobacco smoke. These data were compared with the 2 reference groups in a cross-sectional analysis. RESULTS. The prevalence of obesity (BMI > 95th percentile) was significantly higher in the Head Start children with asthma compared with the NHANES children (P < .001) and the prekindergarten children (P < .05). Compared with Head Start children with a BMI at <85th percentile, Head Start asthmatic patients with a BMI at >85th percentile reported significantly more school days missed, lifetime hospitalizations, emergency department visits, activity limitations, and oral corticosteroid bursts. No significant differences were observed in rescue and controller medications, environmental tobacco smoke exposure, prick-puncture allergy testing, quality of life, or nighttime symptoms. CONCLUSIONS. Obesity (BMI > 95th percentile) was associated with increased asthma prevalence and morbidity. There was no association with the number or type of asthma medications or atopic status. REVIEWER COMMENTS. This is another study showing the association of obesity and asthma. In this study, 18.8% of the Head Start children with asthma had a BMI at >95th percentile, compared with 10.8% of the NHANES and 14.4% of the prekindergarten general-population children. The mechanisms of association have not been clearly established. Both conditions are characterized by chronic inflammation.
Stroop process dissociations: the relationship between facilitation and interference.

L.L. Jacoby's (1991) "process dissociation procedure" was used to quantitatively estimate the contributions of color-naming and word-reading processes to responding on the Stroop task. The results show that color naming and word reading can operate independently to determine responses. Degrading stimulus colors eliminated the typical asymmetry between Stroop facilitation and interference, as predicted by the equations (Experiments 1 and 2). Degrading stimulus colors reduced the estimated contribution of color naming to responding but had no effect on the estimated contribution of word reading (Experiment 2). In contrast, increasing the proportion of incongruent items reduced the estimated contribution of word reading but had no effect on the estimated contribution of color naming (Experiments 3 and 4). The results indicate that the facilitating and interfering effects of automatic processes cannot be accurately measured in terms of differences from baseline.
Dynamic cell shapes and contacts in the developing Drosophila retina are regulated by the Ig cell adhesion protein hibris

Cell shapes and contacts are dynamically regulated during organogenesis to enable contacts with relevant neighboring cells at appropriate times. During Drosophila larval eye development, an apical contact is established between one pair of non‐neuronal cones cells, precluding contact between the opposing pair. Concurrent with changes in cell shape, these contacts reverse in early pupal life. The reversal in cone cell contacts occurs in a posterior to anterior gradient across the eye, following the developmental gradient established in the larval eye imaginal disc. Hibris (Hbs), an Immunoglobulin cell adhesion molecule homologous to vertebrate Nephrin, is required for cone cell morphogenesis. In hbs null mutants, a majority of cone cells fail to both establish wild‐type contacts and achieve mature cone cell shapes. hbs acts cell autonomously in the cone cells to drive these changes. The work presented here indicates hbs contributes to the remodeling of cell contacts and cell shapes throughout development. Developmental Dynamics 238:2223–2334, 2009. © 2009 Wiley‐Liss, Inc.
The political blog space: A new arena for political representation?

While the academic interest in the political blogosphere has grown exponentially in recent years, existing research is predominantly dedicated to political campaigning. In view of the “diminishing prestige of the electoral process” and the “rise of new forms of legitimacy” a broader political analysis of blogs is called for. This article investigates whether the political blogosphere is an arena for political representation by asking (1) how representatives communicate with citizens through blogging in order to aid central functions of political representation, such as accountability, connectivity, and inquiry, and (2) what strategic, technological, and normative factors explain differences in representatives’ communication with citizens. The empirical analysis, based on a survey questionnaire targeting all Swedish blogging representatives, illuminates four different approaches to blogging, with different drivers and implications for the representative democracy.
Intellectual property rights and knowledge sharing across countries

Purpose – The purpose of this paper is to integrate the empirical and game theoretical approaches to address the strategic interactions among countries in choosing their optimal levels of intellectual property rights (IPRs), and to identify how these countries can reach an efficient and equitable equilibrium.Design/methodology/approach – Because countries' decisions on which IPR standards and protections to implement are interrelated, the authors apply game theory to characterize the scenarios before and after the 1994 Agreement on Trade‐related Intellectual Property Rights (TRIPS) involving developed and developing countries.Findings – The model shows that the pre‐TRIPS equilibrium is comprised of high‐income (H‐I) developed countries which choose a strong IPR protection while the middle‐income (M‐I) and low‐income (L‐I) developing countries choose a weak IPR standard. For countries to move from such an equilibrium to the uniformly strong IPR regime under TRIPS, it is necessary for the H‐I countries to c.
Mushrooming Communities: A Field Guide to Mycology in Community Forests

Forest community connections are crucial to ensure forest stewardship and sustainability. We set to explore the potential of mushrooming to enable such connections in contexts were these were historically broken, alienating local people from forests. Taking the case of the recent devolution of a community forest in central Portugal (baldios) to the local population, the authors present a five-year pilot project to rework mycology from a mushroom-centered approach to a mushroom-in-baldios approach. Mushrooms were used as an entry-point to connect the forest ecology with the challenges of governance and community building. The devised activities provided an opportunity for people inside and outside the local community to adventure into the woods, find about their socio-ecological history, develop communal and convivial relationships and engage in the responsible gathering of wild mushrooms. However, the hosting of mushroomers to know, value and engage with the community forest recovery is constantly worked against the enclosure of mushrooms to provide marketable forms of leisure. The outcome will depend on the relationships established between mushrooms, mycologists, local administrators, commoners and poachers, operating within a framework that favors the eradication of resources instead of the longterm relationships that sustain places.
Welfare Reform, Employment, and Drug and Alcohol Use Among Low‐Income Women

&NA; In 1996 welfare reform legislation transformed income assistance for needy families by imposing work requirements, time‐limited benefits, and explicit provisions allowing states to sanction recipients who fail to meet program requirements. Though they represent a minority of the welfare population, women with substance use disorders (SUDs) experience multiple, and more severe, employment barriers than other Temporary Assistance to Needy Families (TANF) recipients. This review of welfare reform, substance abuse, and employment documents the evidence to date regarding the employment patterns of women with SUDs before and after welfare reform, and proposes several topics for further research. Based on higher rates of unemployment, less work experience, and lower earnings when working, women with SUDs have worse employment records than other TANF recipients. Despite elevated employment barriers, women with SUDs left TANF after 1996 as fast as, or faster than, other women. Since the 1996 welfare reform, women with SUDs have increased their employment and earnings, but by less than similar women without SUDs. Future research should describe how specific state welfare policies relate to employment of low‐income women with SUDs, how the well‐being of these women and their children changes with employment, and how welfare and employment interact to affect access to health insurance among this population.
Corrigendum to “A Comparison of Malicious Interdiction Strategies Against Electrical Networks”

This note is to correct an error in the published manuscript of [1]. Specifically, it appears that one step in preparation of the test systems was not correctly implemented. To quote from Section IV B. System and Load Normalisation: “In each system, where multiple branches connected the same two buses, they were merged. This allows a fairer application of topological measures which don’t consider that edges can have inherent redundancy. The merged line’s impedance and thermal limits were updated to match the electrical characteristics of the multiline parallel combination. ” However, inspection of the original scripts [2] which are meant to implement this step indicates that while such mergings were calculated, they were not appropriately recorded. This means that the test system data available at [3] includes unmerged parallel branches, and this is reflected in the branch counts provided in TABLE I of [1]. For transparency, both the original and corrected versions of the relevant script, BatchNormalizeSystems.m, have been uploaded to the persistent Figshare repository, alongside some other scripts used to produce these results [2]. This error in test system preparation changes the interpretation of [1]’s results. In particular, the topological measures simulated there will perform differently, and likely more effectively, if applied to systems having appropriately merged parallel branches. The author wishes to apologise for this error in test system preparation.
Transient Middle Cerebral Artery Occlusion by Intraluminal Suture: I. Three-Dimensional Autoradiographic Image-Analysis of Local Cerebral Glucose Metabolism—Blood Flow Interrelationships during Ischemia and Early Recirculation

Using autoradiographic image-averaging strategies, we studied the relationship between local glucose utilization (LCMRglc) and blood flow (LCBF) in a highly reproducible model of transient (2-hour) middle cerebral artery occlusion (MCAO) produced in Sprague-Dawley rats by insertion of an intraluminal suture coated with poly-L-lysine. Neurobehavioral examination at 60 minutes after occlusion substantiated a high-grade deficit in all animals. In two subgroups, LCBF was measured with 14C-iodoantipyrine at either 1.5 hours of MCAO, or at 1 hour of recirculation after suture removal. In two other matched subgroups, LCMRglc was measured with 14C-2-deoxyglucose at 1.5 to 2.25 hours of MCAO, and at 0.75 to 1.5 hours of recirculation after 2 hours of MCAO. Average image data sets were generated for LCBF, LCMRglc, and the LCMRglc/LCBF ratio for each study time. Middle cerebral artery occlusion for 2 hours induced graded LCBF decrements affecting ipsilateral cortical and basal ganglionic regions. After 1 hour of recirculation, LCBF in previously ischemic neocortical regions increased by 40% to 200% above ischemic levels, but remained depressed, on average, at about 40% of control. By contrast, frank hyperemia was noted in the previously ischemic caudoputamen. Mean cortical LCBF values during MCAO correlated highly with their respective LCBF values after 1 hour of recirculation (R = 0.93), suggesting that postischemic LCBF recovery is related to the depth of ischemia. Despite focal ischemia, LCMRglc during ~2 hours of MCAO was preserved, on average, at near-normal levels; but following ~1 h of recirculation, LCMRglc became markedly depressed (on average, 55% of control in previously densely ischemic cortical regions). Regression analysis indicated that this depressed glucose utilization was determined largely by the intensity of antecedent ischemia. By pixel analysis, the ischemic core (defined as LCBF 0% to 20% of control) comprised 33% of the ischemic hemisphere, and the penumbra (LCBF 20% to 40%) accounted for 26%. The penumbra was concentrated at the coronal poles of the ischemic lesion and formed a thin shell around the central ischemic core. During 2 hours of MCAO, the LCMRglc/LCBF ratio within the ischemic penumbra was increased four-fold above normal (average, 179 umol/100 mL). In marked contrast, after ~1 h recirculation, this uncoupling had almost completely subsided. The companion study (Zhao et al., 1997) further analyzes these findings in relation to patterns of infarctive histopathology.
Design and simulation of a battery powered electric vehicle implementing two different propulsion system configurations

This paper presents a design and simulation of a powertrain system for battery powered electric vehicle (EV). Two different configurations are used for the EV propulsion system. The rear wheels of EV are driven by one traction motor through a differential system, and the front wheels are driven by two other traction motors coupled directly in-wheels. Permanent magnet synchronous motors (PMSM) are adopted as the traction motors. Rule-based power management and control (PMC) strategy is presented to manage and control the power flow between rear and front drive systems. Simulation of the whole EV model is established using AVL CRUISE. Vehicle performance under the new European driving cycle (NEDC) is calculated and presented in the simulation results to specify the potential of the proposed system.
Molecular cloning of a full-length cDNA for human type 3 adenylyl cyclase and its expression in human islets.

The GK (Goto-Kakizaki) rat is a lean model of type 2 diabetes in which the diabetic state was spontaneously induced. We recently demonstrated the presence in GK rats of two functional point mutations in the promoter region of the type 3 adenylyl cyclase (AC3) gene that resulted in overexpression of AC3 mRNA associated with increased cAMP generation. The AC3 gene promoter mutations are the first molecular changes to be described in any specific gene in the GK rat. Here we report cloning of a full-length cDNA encoding human AC3 from a human fetal brain cDNA library using a PCR-based screening method. This 4142-bp cDNA predicts an open reading frame encoding 1144 amino acids containing putative 12 transmembrane-spanning domains which are typically found in other mammalian AC isoforms. Comparison of the translated amino acid sequence of the AC3 gene between human and rat shows 95% homology. Using RT-PCR, clear AC3 expression was detected in isolated human islets as well as a cDNA panel containing templates from eight different tissues (brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle). This wide distribution of AC3 expression may involve a number of physiological and pathophysiological metabolic processes.