Miracle-dz/UniFAR-FTUs huggingface dataset:
A Computer Aided System to Measure Mandibular Cortical Width on Dental Radiograph in Prediction of Osteoporosis

Osteoporosis is a musculoskeletal disorder affecting the population in millions all over the globe. It is an epidemic and mainly under diagnosed in the most developing nations. The association between oral and bone health has been well researched and accepted. The aim of the study is to develop a computer-aided system to diagnose osteoporosis from digital dental panoramic radiograph (DPR) in an economical manner. DPR was obtained from older women aged greater than 40 with an informed consent in their own language for 22 females under consideration. The DPR was taken using X MIND PANO D+ scanner and Bone mineral density (BMD) assessment at skeletal sites (forearm, heel) using p-DXA system (OsteoSys EXA 3000). The WHO classification scheme was adopted to classify the subjects as normal and osteoporotic groups. The ROI was manually marked size of $256 \times 256$ pixels around the mental foramen and the acquired DPR were preprocessed by means of contrast stretching, histogram equalization thresholding and high pass filtering to attain the foreground information. The cortical bone boundaries were determined by means of active contour. The distance between the lower and the upper border of mandible was determined by Euclidean distance approach and designated as Mandibular cortical width (MCW). It was found that the MCW measured using the proposed system could exhibit appreciable results in comparison with the measurement made with the MCW determined using the manual approach. The results of the study infer that MCW measured from DPR could be useful in diagnosing Osteoporosis.
A Label-Free Quantitative Proteomic Analysis of Mouse Neutrophil Extracellular Trap Formation Induced by Streptococcus suis or Phorbol Myristate Acetate (PMA)

Streptococcus suis (S. suis) ranks among the five most important porcine pathogens worldwide and occasionally threatens human health, particularly in people who come into close contact with pigs or pork products. An S. suis infection induces the formation of neutrophil extracellular traps (NETs) in vitro and in vivo, and the NET structure plays an essential role in S. suis clearance. However, the signaling pathway by which S. suis induces NET formation remains to be elucidated. In the present study, we used a label-free quantitative proteomic analysis of mouse NET formation induced by S. suis or phorbol myristate acetate (PMA), a robust NET inducer. Greater than 50% of the differentially expressed proteins in neutrophils infected by S. suis showed similar changes as observed following PMA stimulation, and PKC, NADPH oxidase, and MPO were required for NET formation induced by both stimuli. Because PMA induced robust NET formation while S. suis (MOI = 2) induced only weak NET formation, the association between the inducer and NET formation was worth considering. Interestingly, proteins involved in peptidase activity showed significant differential changes in response to each inducer. Of these peptidases, MMP-8 expression was obviously decreased in response to PMA, but it was not significantly changed in response to S. suis. A subsequent study further confirmed that MMP-8 activity was inversely correlated with NET formation induced by both stimuli. Therefore, the present study provides potentially important information about the manner by which neutrophils responded to the inducers to form NETs.
Projection Mapping for Enhancing the Perceived Deliciousness of Food

The perceived deliciousness of a food item is highly related to its appearance. Image processing has been widely used to make food images more appealing to the public, such as when capturing and posting images on social networking sites. This paper proposes a methodology and a system to enhance the degree of subjective deliciousness perceived by a person based on the appearance of a real-food item by changing its appearance in a real environment. First, an online questionnaire survey was conducted to analyze the appearance factors that make food look delicious by using various food images. Based on this knowledge, a prototype system, which projects a computer-generated image onto the food item, was constructed for enhancing its subjective degree of deliciousness based on its appearance at a pixel level. Finally, a user study was conducted in which the subjective degree of deliciousness based on the food appearance was compared under various appearance modification conditions. The results show that appropriate chroma and partial-color modifications highly increase this degree of deliciousness, thus implying that the proposed system can successfully be used to improve the appearance of food to make it look more delicious.
New Alternatives to Optimize Policy Classifiers

Growing expressiveness of services increases the size of a manageable state at the network data plane. A service policy is an ordered set of classification patterns (classes) with actions; the same class can appear in multiple policies. Previous studies mostly concentrated on efficient representations of a single policy instance. In this work, we study space efficiency of multiple policies, cutting down a classifier size by sharing instances of classes between policies that contain them. In this paper we identify conditions for such sharing, propose efficient algorithms and analyze them analytically. The proposed representations can be deployed transparently on existing packet processing engines. Our results are supported by extensive evaluations.
Analysis of the Technology Acceptance Model (TAM) on Survey System Based Smartphone by the National Population and Family Planning Indonesia

There is a change in the technique or method of collecting and processing data on the Performance Monitoring Accountability (PMA) 2020 Survey by the National Population and Family Planning Indonesia, from a paper-based system to electronic-based which paperless system, one of the tools called Open Data Kit. This study was therefore aimed at identifying the users' perception and attitude towards the application of the new technology in this survey in Indonesia. One of the methods to determine the extent to which the users' acceptance of the application of a new technology is to use the Technology Acceptance Model. Data analysis was performed using the Structural equation Modelling with Analysis of Moment Structure software. The analysis results prove that out of six hypotheses, only one hypothesis is rejected. The results suggest that the application of a new technology system is acceptable and has no resistance from the supervisors and enumerators as the of smartphone-based surveys users. In conclusion, this technology is possible to apply in other surveys in Indonesia.
Early Onset Scoliosis: Is there an Improvement in Quality of Life With Conversion From Traditional Growing Rods to Magnetically Controlled Growing Rods?

Background: Modern treatment of early onset scoliosis (EOS) includes implantation of traditional growing rods (TGR) or magnetically controlled growing rods (MCGR) for posterior-based distraction if nonoperative treatment plans failed. The recent MCGR innovation has largely been expected to improve patient and family burden by avoiding frequent return to the operating room. At least one study has shown no HRQoL difference between TGR and MCGR, but none have specifically investigated a cohort of conversion patients whose families have experienced both. Methods: An EOS database was queried for all patients treated with TGR, MCGR, and those converted from TGR to MCGR who had at least 1 pretreatment and 1 posttreatment HRQoL assessment (EOSQ-24). Data on demographics, diagnoses, and major curve size, as well as EOSQ-24 domain scores were studied. Results: There were 156 TGR, 114 MCGR, and 32 conversion patients, with an average of 2.0 years between first and final EOSQ-24 surveys. There was no significant difference in outcome in any EOSQ-24 domain between the converts and the other 2 treatment groups. There was a significant post-op improvement in MCGR versus TGR in transfers and energy level (P=0.01; P=0.01). Conclusions: Although patient families and their surgeons may subjectively report improved HRQoL after conversion from TGR lengthenings to in-office MCGR lengthenings, these improvements were seen in transfer and fatigue domains, not burden or satisfaction. Although the EOSQ-24 is a well-validated EOS metric, it may not be sensitive enough to overcome the QoL floor-effect associated with the diagnosis itself, or perhaps the improvement in QoL must be assessed over a longer interval to assess meaningful change. Level of Evidence: Level III—retrospective comparative study.
STA: Spatial-Temporal Attention for Large-Scale Video-based Person Re-Identification

In this work, we propose a novel Spatial-Temporal Attention (STA) approach to tackle the large-scale person reidentification task in videos. Different from the most existing methods, which simply compute representations of video clips using frame-level aggregation (e.g. average pooling), the proposed STA adopts a more effective way for producing robust clip-level feature representation. Concretely, our STA fully exploits those discriminative parts of one target person in both spatial and temporal dimensions, which results in a 2-D attention score matrix via inter-frame regularization to measure the importances of spatial parts across different frames. Thus, a more robust clip-level feature representation can be generated according to a weighted sum operation guided by the mined 2-D attention score matrix. In this way, the challenging cases for video-based person re-identification such as pose variation and partial occlusion can be well tackled by the STA. We conduct extensive experiments on two large-scale benchmarks, i.e. MARS and DukeMTMCVideoReID. In particular, the mAP reaches 87.7% on MARS, which significantly outperforms the state-of-the-arts with a large margin of more than 11.6%.
A 28 GHz Low Phase-Noise Colpitts VCO with Wide Tuning-Range in SiGe Technology

A fully integrated low phase-noise and wide tuning-range differential Colpitts voltage-controlled-oscillator (VCO) designed and fabricated in 0.13um SiGe BiCMOS technology at 28 GHz for 5G wireless communications is presented. The proposed VCO utilizes inductive emitter degeneration and resistive tail bias to achieve low phase noise and wide tuning range. The measured phase noise is about −109.1 dBc/Hz at 1 MHz offset at a center frequency of 27.6 GHz and the measured tuning range is from 25.1 GHz to 29.9 GHz (17.3%). The measured output power delivered by the VCO is +6.5 dBm. Both the phase noise and the tuning range of this work are comparable with other silicon-based VCOs around 28 GHz.
Over-the-scope-clips as primary and rescue therapy for non-variceal gastrointestinal bleeding: a systematic review and meta-analysis.

INTRODUCTION Endoscopic hemostasis in patients with non-variceal bleeding (NVGIB) with standard therapy has improved outcomes. However, persistent bleeding and re-bleeding continues to drive morbidity and mortality. Use of over-the-scope clips (OTSC) is an emerging treatment modality for managing gastrointestinal (GI) bleeding. We performed a systematic review and meta-analysis to evaluate the ability of OTSC to achieve primary hemostasis and re-bleeding rates as primary therapy and rescue endoscopic interventions in patients with NVGIB. EVIDENCE ACQUISITION We searched articles in PubMed, Ovid Medline In- Process & Other Non-Indexed Citations, Embase, Ovid Cochrane Central Register of Controlled Trials, Ovid Cochrane Database of Systematic Reviews, and Scopus from inception to July 2017 using keywords such as "OTSC" and "NVGIB. " EVIDENCE SYNTHESIS A total of 16 studies which involved 475 patients met the inclusion criteria. 288 patients were treated with OTSC as primary therapy while 187 patients were treated with OTSC as rescue therapy. Primary hemostasis rate achieved with primary endoscopic therapy with OTSC was 0.93 (95% CI: 0.89-0.96). Similarly, primary hemostasis rate achieved with rescue endoscopic therapy with OTSC was 0.91 (95% CI: 0.84-0.95). Re-bleeding rates after primary endoscopic therapy with OTSC was 0.21 (95% CI:0.08-0.43) and 0.25 (95% CI:0.17-0.34) with rescue therapy. There was a decreased risk of re-bleeding in patients treated with OTSC as primary therapy versus rescue therapy. RR=0.52 (95% CI: 0.31-0.89). CONCLUSIONS This meta-analysis demonstrates success on the use of OTSC as primary and rescue therapy in the management of NVGIB. Further trials should clarify the ideal setting for the use of OTSC and assess the cost of these devices as compared to standard therapy.
NLP-Enriched Automatic Video Segmentation

E-learning environments are heavily dependent on videos as the main media to deliver lectures to learners. Despite the merits of video-based lectures, new challenges can paralyze the learning process. Challenges that deal with video content accessibility, such as searching, retrieving, explaining, matching, organizing, and even summarizing these contents, significantly limit the potential of video-based learning. In this paper, we propose a novel approach to segment video lectures and integrate Natural Language Processing (NLP) tasks to extract key linguistic features exist within the video. We exploit the benefits of visual, audio, and textual features in order to create comprehensive temporal feature vectors for the enhanced segmented video. Afterwards, we apply an NLP cosine similarity to the cluster and identify the various topics presented in the video. The final product would be an indexed, vector-based searchable video segments of a specific topic/subtopic
Short-term outcome of the second twin during vaginal delivery is dependent on delivery time interval but not chorionicity

Abstract The decrease in pH in monochorionic (MC) second twin may exceed that of dichorionic (DC) second twin during vaginal twin delivery. The aim of this study was to investigate the effect of chorionicity on the umbilical artery pH of the second twin in relation to increased twin-to-twin delivery time interval (DTI) from 30 weeks of gestation. A hospital based cohort of all twin deliveries after 30 completed weeks of gestation with the first twin delivered vaginally between 2007 and 2012 in four delivery units in Stockholm county was conducted. The changes of umbilical pH in MC twins compared to DC twins in relation to twin-to-twin DTI was studied using linear regression. The predictors for acidosis (pH ≤ 7.10) in the second twin were studied by logistic regression. The cohort included 681 DC and 186 MC twin pairs. There was a correlation between the umbilical pH and the twin-to-twin DTI but independent of the chorionicity, the pH decreased in average by 0.0012 units/min (p < .001). Twin-to twin DTI was a predictor for acidosis of the second twin (p < .01). IMPACT STATEMENT What is already known on this subject? Vaginal twin deliveries are a major obstetrical challenge because of the increased risk for the second twin after the delivery of the first twin, and are suggested to increase among premature second twins. Previous studies report a continuous decline in the pH of the second twin during the second stage of labour, with an increased risk for acidosis (pH < 7.10) and Apgar scores <7 for twin-to-twin delivery time interval (DTI) as short as 15–30 min. Major studies have not discriminated between MC and DC vaginally delivered twins and the question rise if there is a reason for different delivery guidelines for MC diamniotic second twin compared to DC second twin. What do the results of this study add? The results of the present study show a correlation between umbilical pH and twin-to-twin DTI, but independent of chorionicity, from gestational week 30 to term. A main predictor for acidosis (pH ≤ 7.10) is the twin-to-twin DTI. What are the implications of these findings for clinical practice and/or future research? In cases of uneventful MC pregnancies, we find no support to suggest different vaginal delivery guidelines for MC diamniotic twins compared to DC twins. The risk for acidosis in the second twin increased with 1%/min during the second stage. Active management may be recommended after 15–30 min.
Analisa Faktor-Faktor yang Mempengaruhi Proses Belajar Guru-Guru Sekolah Dasar

The purpose of this research is to know and describe factors influencing elementary school teachers in Biak Numfor District, and efforts made by elementary school teachers of Biak and suggestions for the development of education especially in Biak Numfor District. The method used in this research is descriptive. The research subjects were elementary school teachers in Biak Numfor District. Data obtained by distributing instrument in the form of Questionnaire. The results of a questionnaire that was distributed to 31 elementary school teachers in Biak Numfor district showed that many of the obstacles experienced by teachers. Obstacles experienced by elementary school teachers in Biak Numfor district are teachers experiencing obstacles in preparing the lesson, teachers experience barriers in determining methods and media used in learning, teachers experience barriers in determining the evaluation used in learning. Efforts by teachers to overcome these obstacles are many students who do not have a handbook then the teachers, and teachers use the media in school. Teachers hope the attention of local governments need to be improved again.
The Development of an AAV-Based CRISPR SaCas9 Genome Editing System That Can Be Delivered to Neurons in vivo and Regulated via Doxycycline and Cre-Recombinase

The RNA-guided Cas9 nuclease, from the type II prokaryotic clustered regularly interspersed short palindromic repeats (CRISPR) adaptive immune system, has been adapted by scientists to enable site specific genome editing of eukaryotic cells both in vitro and in vivo. Previously, we reported the development of an adeno-associated virus (AAV)-mediated CRISPR Streptococcus pyogenes (Sp) Cas9 system, in which the genome editing function can be regulated by controlling the expression of the guide RNA (sgRNA) in a doxycycline (Dox)-dependent manner. Here, we report the development of an AAV vector tool kit utilizing the Cas9 from Staphylococcus aureus (SaCas9). We demonstrate in vitro genome editing in human derived 293FT cells and mouse derived Neuro2A (N2A) cells and in vivo in neurons of the mouse brain. We also demonstrate the ability to regulate the induction of genome editing temporally with Dox and spatially with Cre-recombinase. The combination of these systems enables AAV-mediated CRISPR/Cas9 genome editing to be regulated both spatially and temporally.
Comparison of Biomechanical Properties and Microstructure of Trabeculae Carneae, Papillary muscles, and Myocardium in Human Heart.

Trabeculae carneae account for a significant portion of human ventricular mass, despite being considered embryologic remnants. Recent studies have found trabeculae hypertrophy and fibrosis in hypertrophied left ventricles with various pathological conditions. The objective of this study was to investigate the passive mechanical properties and microstructural characteristics of trabeculae carneae and papillary muscles compared to the myocardium in human hearts. Uniaxial tensile tests were performed on samples of trabeculae carneae and myocardium strips, while biaxial tensile tests were performed on samples of papillary muscles and myocardium sheets. The experimental data were fit to a Fung-type strain energy function and material coefficients were determined. The secant moduli at given diastolic stress and strain levels were determined and compared among the tissues. Following the mechanical testing, histology examinations were performed to investigate the microstructural characteristics of the tissues. Our results demonstrated that the trabeculae carneae were significantly stiffer (Secant modulus SM2=80.06±10.04 KPa) and had higher collagen content (16.10±3.80%) than the myocardium (SM2=55.14±20.49 KPa, collagen content=10.06±4.15%) in the left ventricle. The results of the present study improve our understanding of the contribution of trabeculae carneae to left ventricular compliance and will be useful for building accurate computational models of human hearts.
Mixed effects of restriction strategies in antimicrobial stewardship programs on antimicrobial use in 121 tertiary hospitals in China, 2013–2017

ABSTRACT Background: The research evaluated the impact of intravenous antimicrobial restriction strategy (IARS) on different types of hospitals in China for evidence-based management, for outpatients implemented in 2016. Methods: Based on panel data on antimicrobial use in 121 tertiary hospitals in Zhejiang, China, segmented regression analysis was used to evaluate the impact of IARS in children’s hospitals (CHs), obstetrics and gynecology hospitals (OGHs), women’s and children’s hospitals (WCHs), traditional Chinese medicine hospitals (TCMHs) and general hospitals (GHs). Antimicrobial use was measured using the percentage of total encounters with prescribing and the percentage of total drug expenditure relating to antimicrobials (APP and AEP). Results: There was a downward baseline slope of APP in all types of hospitals and AEP in WCHs, TCMHs and GHs (P < 0.01). After IARS, a level reduction in AEP in CHs (−3.14%, 95% CI = −6.21 to 0.06), WCHs (−1.33%, 95% CI = −2.44 to 0.22) and TCMHs (−0.85%, 95%CI = −1.51 to 0.18). After IARS, the slope of AEP changed significantly in OGHs (−0.42%, 95%CI = −0.81 to 0.03) and WCHs (0.29%, 95% CI = 0.08 to 0.49), and the slope of APP changed significantly in CHs (2.35%, 95%CI = 1.20 to 3.49). Conclusions: IARS had the mixed effects including positive effect in AEP and no significant change in APP, and an unexpected rise in APP in CHs needs further study.
An Improved Particle Swarm Algorithm for Constrained Optimization Problem

Particle swarm optimization is a global random search algorithm that is simulated by mimicking the behavior of migration and aggregation of birds. In order to improve the global search ability of the algorithm, this paper proposes a new inertia weight. For the constrained optimization problem, this paper controls the number of particles that violate the constraint conditions, and proposes a new particle selection method to improve the ability of the particle swarm algorithm to search for boundaries. Finally, experiments were performed using three benchmark functions, and the results show that the optimization speed of the improved particle swarm algorithm has been greatly improved.