Miracle-dz/UniFAR-FTUs huggingface dataset:
An Alternative, Non-Apoptotic Form of Programmed Cell Death

Traditional thought about cell death focuses on two distinct types of events. Apoptosis is characterized by distinct morphological characteristics and specific genetic events; necrosis is described by different morphological characteristics and a lack of genetic control of the death process. However some forms of cell death, including oncosis and some developmental and neurodegenerative cell deaths, do not fit morphological descriptions of necrosis or apoptosis. The biochemical mechanisms by which these alternative cell deaths occur are unknown. In this study, the authors describe a form of cell death that requires gene expression but does not conform to morphological and biochemical criteria for apoptosis.
A convergence algorithm to help enhance the performance of distributed systems on large networks

The proposed convergence algorithm quickly and accurately predicts the mean message response time and communication channel. From the predicted value the correct window size of the desired percentage of time-out tolerance in message transmission and response can be computed. A correct window size is a necessity for reducing excessive message retransmissions caused by time-outs. The convergence algorithm is particularly useful for enhancing the performance of time-critical distributed applications running on large networks such as the Internet. Prolonged delays in message response in these systems may lend to fatal errors. The discussion in this paper concentrates mainly on the theory and verification of the convergence algorithm. The simulation results have confirmed that the proposed algorithm is indeed a cost/effective solution for enhancing system performance. The simplicity of the convergence algorithm makes it worthwhile for practical implementation in real systems.
National Centre of Competence in Research Financial Valuation and Risk Management

We study a test statistic based on the integrated squared difference between a kernel estimator of the copula density and a kernel smoothed estimator of the parametric copula density. We show for fixed smoothing parameters that the test is consistent and that the asymptotic properties are driven by a U -statistic of order 4 with degeneracy of order 1. For practical implementation we suggest to compute the critical values through a semiparametric bootstrap. Monte Carlo results show that the bootstrap procedure performs well in small samples. In particular size and power are less sensitive to smoothing parameter choice than they are under the asymptotic approximation obtained for a vanishing bandwidth.
Employability of local trained skill labour in construction industry

Development in Malaysia is booming which can be witnessed by the various construction projects that currently in progress, especially in the state of Johor which has the highest value of construction work completed for the third quarter of 2016. This necessarily requires skilled labours in a high number especially among the locals since it has been reported that Malaysia’s construction industry is having problems related to the shortage of local skilled labour. In addition, the local workers have been reported to unable to fulfil the demand of construction market and this have caused the contractor to import foreign workers to meet the needs and requirement of labour market in construction sector. The objectives of this study are to determine the criteria set by the construction company in recruiting local skilled labour and to study the strategies that can attract local skilled labour to join construction industry. Questionnaire has been distributed to G7 contractor in the state of Johor in order to achieve the objectives of this study. Collected data was then evaluated and tested for its reliability using the SPSS 20.0 software before it can be analysed in order to obtain the mean value, frequencies and percentage. The outcome of this study indicates that the prospective employer prefers to work with man and they require young, experienced, knowledgeable and skilled workers in doing the job. Most of the strategies that have been selected are mainly related to money namely salary increment, bonus, allowance and overtime payment, apart from upgrading labours welfare and providing a better accommodation. This study can be a guideline to both skills institution and contractor to improve on what they are lacking in order to encourage the local trained skills labour to join the industry.
Modulatory factors in the effect of energy density on energy intake

The effect of energy density (ED) on energy intake (EI) has been assessed in short-term and long-term experiments. In the short term, it was found that ED affects EI directly in situations when the subjects cannot estimate the ED of the food; then subjects mainly monitor the weight of the food ingested. In the long term, the effects of ED on EI are modulated. Average daily EI appears to be related to ED of the food and drinks when ED is determined by specific macronutrients, but not when ED is only determined by the weight of water. Thus, the short-term effect ED has on EI cannot be extrapolated to the long term, because a possible dominating effect of the weight of water determining ED undoes the relationship of ED with EI. Moreover, in the long-term portion sizes are used to compensate for correctly estimated ED, resulting in less variation in EI than ED alone would imply. Finally, dietary restraint compensates for the effect of a relatively high ED on daily EI, whereas dietary unrestraint compensates for the effect of relatively low ED on daily EI. We conclude that the short-term effect of ED on EI is modulated by the effect of water on ED, and compensated for by the effect of dietary restraint and adapted portion sizes.
Screening for developmental delay among children aged 1-4 years: a systematic review.

BACKGROUND Existing guidelines on screening children less than 5 years of age for developmental delay vary. In this systematic review, we synthesized the literature on the effectiveness and harms of screening for developmental delay in asymptomatic children aged 1-4 years. METHODS We searched MEDLINE, Embase and PsychINFO for relevant articles published to June 16, 2015. We identified studies that included children aged 1-4 years who were not at high risk of developmental delay, screened in a primary care setting. Randomized trials and controlled cohort studies were considered for benefits (cognitive, academic and functional outcomes); no restrictions on study design were imposed for the review of harms. RESULTS Two studies were included. One used the Ages and Stages Questionnaire II for screening and reported significantly more referrals to early intervention in the intervention groups than in the control group (relative risk [RR] 1.95, 95% confidence interval [CI] 1.49-2.54, in the intervention group with office support and RR 1.71, 95% CI 1.30-2.25, in the intervention group without office support). The time to referral was 70% shorter in the intervention group with office support (rate ratio 0.30, 95% CI 0.19-0.48) and 64% shorter in the intervention group without office support (rate ratio 0.36, 95% CI 0.23-0.59), compared with the control group. The other study used the VroegTijdige Onderkenning Ontwikkelingsstoornissen Language Screening instrument to screen children aged 15 months at enrolment for language delay. It reported no differences between groups in academic performance outcomes at age 8 years. INTERPRETATION The evidence on screening for developmental delay in asymptomatic children aged 1-4 years is inconclusive. Further research with longer-term outcomes is needed to inform decisions about screening and screening intervals.
One‐week triple therapy with esomeprazole, clarithromycin and metronidazole provides effective eradication of Helicobacter pylori infection

Aim: To compare the eradication rates of treatment with esomeprazole, metronidazole and clarithromycin (EMC) vs. omeprazole, metronidazole and clarithromycin (OMC), given for 7 days. OMC treatment was followed by 3 weeks of treatment with 20 mg omeprazole alone; the EMC group received placebo.
Concurrent action observation modulates practice‐induced motor memory formation

Motor practice is associated with the formation of elementary motor memories. Here we tested in human subjects the hypothesis that observation of a motor training associated with physical practice will modulate the encoding process of a motor memory relative to physical practice alone. Voluntary thumb motions were practiced (i) alone in a direction opposite to the baseline direction of transcranial magnetic stimulation (TMS)‐evoked movements (physical practice, PP) and in combination with observation of synchronous movements that were either (ii) directionally congruent (same direction, PP + AOc) or (iii) non‐congruent (opposite direction, PP + AOnc) to the practiced ones. We evaluated the following measures of motor memory formation: percentage of TMS‐evoked thumb movements falling in the direction of practiced motions, acceleration of TMS‐evoked movements along the principal movement axis and corticomuscular excitability of training muscles as indexed by motor‐evoked potential amplitudes. Both PP and PP + AOc, but not PP + AOnc, significantly increased the percentage of TMS‐evoked movements falling in the practiced direction, changed the compound acceleration vector into the trained direction and enhanced the motor‐evoked potential amplitudes in the training agonist muscle. The percentage of TMS‐evoked movements falling in the practiced direction increased significantly more after PP + AOc than after PP. Across all measures of motor memory formation, PP + AOc was most efficacious, followed by PP and PP + AOnc. Action observation modulates practice effects on formation of a motor memory. Strengthening of the process of motor memory encoding depends on the directional congruency of the observed model.
Go/No-Go Decision-Making Method on Business Development of Software Development in Indonesia

Entrepreneurs start their business by planning their business either documented or undocumented. The business plan is executed after considering various aspects of the related business has been met. Execution of business plan (Go / No-Go decision) is thought to be a repeating activity by entrepreneurs as well as innovation that always done for developing and sustaining the business. Effective decision-making method of business plan execution are required to generate time, energy and resource efficiency, especially in the business plan execution of the software development field. This research uses qualitative method with sample size of 9 of software development companies in Indonesia, and it is intended to answer research questions: “What method are effective for entrepreneurs / new entrepreneurs in the field of software development to take Go / No-Go decisions from business plans that have been compiled. ” The result of this research is Go / No-Go decision-making method on business development of software development can be decomposed into: Assumption Exploration, assumption selection, assumption testing and take a decision. Some of the main keys are: the business should consider market, product, technology, economy, competition and organization as group of assumptions; and when take a decision, several ways to be taken are: looking at difficulty level and resistance of assumptions, conducting trial and error (doing design fast, and tested to customer), conducting market test and seeing result, and interview with user. Research paper Keywords: Business Development, Decision, Go / No-Go, Method Reference to this paper should be made as follows: Taufik, C. , & Karyadi (2018). Go/No-Go Decision-Making Method on Business Development of Software Development in Indonesia, Journal of Entrepreneurship, Business and Economics , 6 (2), 71–90.
Creating tight proximal contacts for MOD resin composite restorations.

OBJECTIVE The purpose of this study was to compare proximal contact tightness (PCT) of MOD resin composite restorations placed with different matricing protocols. METHODS Forty-five ivorine lower right first molars with standardized MOD cavities were equally divided into three groups according to the restoration protocol. Group 1: Sectional matrix (Standard matrix, Palodent, Dentsply) secured with a wedge (Premier Dental Products Co.) and separation ring (BiTine I, Palodent, Dentsply, York, PA, USA) was used to restore the mesial surface first and then removed and repeated for the distal surface. Group 2: Identical to group 1, but separation rings were placed at both the mesial and distal sides (BiTine I+II, Palodent) prior to restoration. Mesial surface was restored followed by distal. Group 3: Walser matrix (O-form, Dr. Walser Dental GmbH) was used. Following composite resin restoration, PCT was measured using the tooth pressure meter. Data were analyzed using analysis of variance and a Tukey post hoc test (p<0.05). RESULTS PCT values for mesial contacts were 2.99 ± 0.47N for group 1, 4.57 ± 0.36N for group 2, and 3.03 ± 0.79N for group 3. For the distal contacts, the values were 4.46 ± 0.44N for group 1, 5.12 ± 0.13N for group 2, and 0.76 ± 0.77N for group 3. Significantly tighter contacts were obtained for mesial and distal contacts for group 2 compared to groups 1 and 3 (p<0.05). For groups 1 and 3, mesial contacts were not significantly different (p=0.993), while distal contacts for group 1 were significantly tighter (p<0.001). CONCLUSION Within the limitations of this study, tighter contacts can be obtained when sectional matrices and separation rings are applied to both proximal surfaces prior to placement of the resin composite in MOD cavities.
Efficacy and Safety of nadroparin and Unfractionated Heparin for the Treatment of Venous Thromboembolism During Pregnancy and

Gorana Mitić1, Mirjana Kovač2, Ljubica Považan1, Valentina Djordjević3, Vesna Ilić4, Iva Salatić1, Radmila Lazić1, Nebojša Antonijević5, Aleksandra Novakov-Mikić1 1 Clinical Centre of Vojvodina, Novi Sad, Serbia; 2 Blood Transfusion Institute of Serbia, Belgrade, Serbia; 3 Institute of Molecular Genetics and Genetic Engineering, Belgrade, Serbia; 4 Military Medical Academy, Belgrade, Serbia; 5 Institute of Cardiovascular Diseases, Clinical Centre of Serbia, Belgrade, Serbia
In-Vitro Synergistic Effect of Fluconazole with Nonsteroidal Anti-Inflammatory Agents Against Candida albicans Strains

Abstract The In-Vitro interaction and synergistic activity of the combination of fluconazole with some nonsteroidal anti-inflammatory drugs (sodium salicylate, piroxicam, tenoxicam and diclofenac sodium) were investigated in Candida albicans strains (n=7) by the microdilution checkerboard assay. The results were evaluated visually and by a spectrophotometric microplate reader at 492 nm wavelength. Fractional inhibitory index was calculated for every strain and combination according to the minimal inhibitory concentration (MICs). The combination of fluconazole with sodium salicylate, tenoxicam and diclofenac sodium showed synergy against 5, 5 and 3 of the C. albicans strains, respectively. The effect of fluconazole with piroxicam was synergistic against one strain but indifferent/additive against the others. These data suggest that combinations of sodium salicylate, tenoxicam and diclofenac sodium with fluconazole may prove to be useful as chemotherapeutic agents for the treatment of C. albicans infections caused by especially fluconazole-resistant strains. However, additional preclinical work and in vivo studies are necessary to determine their definite clinical use.
A View from the Trenches: A Survey of Canadian Clinicians' Perspectives Regarding the Treatment of Borderline Personality Disorder

Objective The goal of this study was to develop a sense of how borderline personality disorder (BPD) is treated in the community. The focus was on psychotherapeutic treatments. Methods A 13-item online questionnaire was distributed to 291 clinicians in the province of British Columbia, Canada. Participants were asked about treatment provision, their opinion of optimal treatment, and clinician confidence using both fixed and open response questions. Results The response rate was 43%. Of the respondents, 64% indicated that they provided treatment to patients with BPD, although two thirds of those responses indicated use of ill-defined treatment approaches. In the responses that involved what could be described as well-defined treatment approaches, dialectical behavior therapy (DBT) was the most frequently mentioned (20%). Most treatments were offered in an individual therapy format (60%); 38% described providing treatment on a long-term basis. Responses concerning optimal treatment for BPD favored DBT (45%), a combined individual-group therapy format (48%), and long-term duration of treatment (42%). Clinician confidence in treating BPD was low and there was a strong desire for further training. Conclusion The community mental health clinicians who were surveyed were aware of the serious nature of BPD and seek to treat the disorder. However, much of the treatment they provide does not conform to what respondents indicated they considered optimal. Clinicians who responded to the survey seemed relatively unaware of empirically supported psychodynamic treatments for BPD. There is a need for improved training and education regarding BPD and for further dissemination of information concerning empirically supported treatments for BPD. (Journal of Psychiatric Practice 2009;15:449–453)
Noninvasive detection of fetal sex: the laboratory diagnostician's view

Toward the end of the twentieth century it was discovered that cell‐free fetal DNA sequences could be detected in maternal blood plasma. Initially, Y‐chromosome sequences originating from male fetuses were targeted in cell‐free DNA extracted from maternal plasma in order to demonstrate proof of this concept towards the development of noninvasive prenatal diagnosis methods. Clinical application of this approach is now possible. Fetal sex can be detected through a procedure that is noninvasive with respect to the fetus. Specifically, the presence of Y‐chromosome sequences in maternal blood plasma indicates that the fetus is male, whereas lack of a signal will indicate that the fetus is female. Fetal sex can be detected very early, from at least the 7th week of pregnancy (and even earlier, according to several studies), about two months before this information is available through ultrasound scanning.
Intensive care unit outcomes among patients with lung cancer in the surveillance, epidemiology, and end results-medicare registry.

PURPOSE Lung cancer is the leading cause of cancer-related mortality. Intensive care unit (ICU) use among patients with cancer is increasing, but data regarding ICU outcomes for patients with lung cancer are limited. PATIENTS AND METHODS We used the Surveillance, Epidemiology, and End Results (SEER) -Medicare registry (1992 to 2007) to conduct a retrospective cohort study of patients with lung cancer who were admitted to an ICU for reasons other than surgical resection of their tumor. We used logistic and Cox regression to evaluate associations of patient characteristics and hospital mortality and 6-month mortality, respectively. We calculated adjusted associations for mechanical ventilation receipt with hospital and 6-month mortality. RESULTS Of the 49,373 patients with lung cancer admitted to an ICU for reasons other than surgical resection, 76% of patients survived the hospitalization, and 35% of patients were alive 6 months after discharge. Receipt of mechanical ventilation was associated with increased hospital mortality (adjusted odds ratio, 6.95; 95% CI, 6.89 to 7.01; P < .001), and only 15% of these patients were alive 6 months after discharge. Of all ICU patients with lung cancer, the percentage of patients who survived 6 months from discharge was 36% for patients diagnosed in 1992 and 32% for patients diagnosed in 2005, whereas it was 16% and 11% for patients who received mechanical ventilation, respectively. CONCLUSION Most patients with lung cancer enrolled in Medicare who are admitted to an ICU die within 6 months of admission. To improve patient-centered care, these results should guide shared decision making between patients with lung cancer and their clinicians before an ICU admission.
Potential of Heterotopic Cardiac Transplantation in Mice as a Model for Elucidating Mechanisms of Graft Rejection

Cardiac transplantation displays a well established therapeutic procedure for different end-stage heart diseases. Effective immunosuppressive drugs, progress in operative techniques, modern perioperative intensive care, and application of increasingly potent antibiotics in case of postoperative infections led to an improvement in short term outcome of organ transplantation. Nevertheless, achievements in long term transplant results are rare due to rejection of allografts. Chronic graft rejection is the major cause of late transplant failure.
Blockchains, the New Fashion in Supply Chains? - The compatibility of blockchain configurations in supply chain management in the fast fashion industry

Background and Purpose: Blockchain Technology has recently, with its disruptive force and revolutionising ways of improving security and data sharing, gotten a lot of attention in both academics and business. Blockchains can be separated into several configurations of blockchains, which all have different benefits and drawbacks. There is, however, a lack of consensus about these different configurations and the existing literature does not provide any comprehensive compilation. Moreover, blockchains are said to have an especially benefiting value in supply chain management. Despite this, the diffusion of the technology and use cases in the fast fashion industry, which is highly reliant on an efficient supply chain, are still near to non-existent. One of the most important factors affecting the diffusion of new technologies has been said to be compatibility. Hence, this study aims to investigate how compatible the different configurations of blockchains are in the supply chain management in the fast fashion industry. Methodology: The research builds on an extensive literature review of blockchain technology and its different configurations, resulting in a compilation of the characteristics distinguishing the configurations. The literature is then extended and built upon by conducting qualitative semi-structured interviews with blockchain experts about the different configurations. In addition to this, fast fashion companies are interviewed, also by semi-structured interviews, about their perception based on each of the characteristics identified in the literature review. Findings and Conclusions: One of the main findings is that the different configurations of blockchains can be distinguished by four clusters of characteristics and that there are tradeoffs evident between them that affect the compatibility of the different configurations. Based on this, a model has been constructed that was used to assess the compatibility of the blockchains configurations in supply chain management in the fast fashion industry. This resulted in the second main finding of the study, which is that even though it has been discussed that there is a lot of benefits achievable by blockchains, the result indicates that no configuration is fully compatible in this aspect studied. However, each configuration can be compatible to a certain extent and can consequently provide value in different settings. It is also identified that a consortium blockchain is adaptable and has the potential to overcome some of the trade-offs. Furthermore, the study provides four recommendations regarding the adoption of the different configurations of blockchains in supply chain management in the fast fashion industry.