Miracle-dz/UniFAR-FTUs huggingface dataset:
Continuous-Time Accelerated Methods via a Hybrid Control Lens

Treating optimization methods as dynamical systems can be traced back centuries ago in order to comprehend the notions and behaviors of optimization methods. Lately, this mindset has become the driving force to design new optimization methods. Inspired by the recent dynamical system viewpoint of Nesterov's fast method, we propose two classes of fast methods, formulated as hybrid control systems, to obtain prespecified exponential convergence rate. Alternative to the existing fast methods, which are parametric-in-time second-order differential equations, we dynamically synthesize feedback controls in a state-dependent manner. Namely, in the first class, the damping term is viewed as the control input, while in the second class the amplitude with which the gradient of the objective function impacts the dynamics serves as the controller. The objective function requires to satisfy the so-called Polyak–Łojasiewicz inequality, which effectively implies no local optima and a certain gradient-domination property. Moreover, we establish that both hybrid structures possess Zeno-free solution trajectories. We finally provide a mechanism to determine the discretization step size to attain an exponential convergence rate.
Cannabidiol as a Therapeutic Alternative for Post-traumatic Stress Disorder: From Bench Research to Confirmation in Human Trials

Post-traumatic stress disorder (PTSD) is characterized by poor adaptation to a traumatic experience. This disorder affects approximately 10% of people at some point in life. Current pharmacological therapies for PTSD have been shown to be inefficient and produce considerable side effects. Since the discovery of the involvement of the endocannabinoid (eCB) system in emotional memory processing, pharmacological manipulation of eCB signaling has become a therapeutic possibility for the treatment of PTSD. Cannabidiol (CBD), a phytocannabinoid constituent of Cannabis sativa without the psychoactive effects of Δ9-tetrahydrocannabinol, has gained particular attention. Preclinical studies in different rodent behavioral models have shown that CBD can both facilitate the extinction of aversive memories and block their reconsolidation, possibly through potentialization of the eCB system. These results, combined with the currently available pharmacological treatments for PTSD being limited, necessitated testing CBD use with the same therapeutic purpose in humans as well. Indeed, as observed in rodents, recent studies have confirmed the ability of CBD to alter important aspects of aversive memories in humans and promote significant improvements in the symptomatology of PTSD. The goal of this review was to highlight the potential of CBD as a treatment for disorders related to inappropriate retention of aversive memories, by assessing evidence from preclinical to human experimental studies.
Hardware Optimizations of Dense Binary Hyperdimensional Computing: Rematerialization of Hypervectors, Binarized Bundling, and Combinational Associative Memory

Brain-inspired hyperdimensional (HD) computing models neural activity patterns of the very size of the brain’s circuits with points of a hyperdimensional space, that is, with hypervectors. Hypervectors are D-dimensional (pseudo)random vectors with independent and identically distributed (i.i.d.) components constituting ultra-wide holographic words: D=10,000 bits, for instance. At its very core, HD computing manipulates a set of seed hypervectors to build composite hypervectors representing objects of interest. It demands memory optimizations with simple operations for an efficient hardware realization. In this article, we propose hardware techniques for optimizations of HD computing, in a synthesizable open-source VHDL library, to enable co-located implementation of both learning and classification tasks on only a small portion of Xilinx UltraScale FPGAs: (1) We propose simple logical operations to rematerialize the hypervectors on the fly rather than loading them from memory. These operations massively reduce the memory footprint by directly computing the composite hypervectors whose individual seed hypervectors do not need to be stored in memory. (2) Bundling a series of hypervectors over time requires a multibit counter per every hypervector component. We instead propose a binarized back-to-back bundling without requiring any counters. This truly enables on-chip learning with minimal resources as every hypervector component remains binary over the course of training to avoid otherwise multibit components. (3) For every classification event, an associative memory is in charge of finding the closest match between a set of learned hypervectors and a query hypervector by using a distance metric. This operator is proportional to hypervector dimension (D), and hence may take O(D) cycles per classification event. Accordingly, we significantly improve the throughput of classification by proposing associative memories that steadily reduce the latency of classification to the extreme of a single cycle. (4) We perform a design space exploration incorporating the proposed techniques on FPGAs for a wearable biosignal processing application as a case study. Our techniques achieve up to 2.39× area saving, or 2,337× throughput improvement. The Pareto optimal HD architecture is mapped on only 18,340 configurable logic blocks (CLBs) to learn and classify five hand gestures using four electromyography sensors.
German Dialect Identification Using Classifier Ensembles

In this paper we present the GDI classification entry to the second German Dialect Identification (GDI) shared task organized within the scope of the VarDial Evaluation Campaign 2018. We present a system based on SVM classifier ensembles trained on characters and words. The system was trained on a collection of speech transcripts of five Swiss-German dialects provided by the organizers. The transcripts included in the dataset contained speakers from Basel, Bern, Lucerne, and Zurich. Our entry in the challenge reached 62.03% F1 score and was ranked third out of eight teams.
Illusory resizing of the painful knee is analgesic in symptomatic knee osteoarthritis

Background Experimental and clinical evidence support a link between body representations and pain. This proof-of-concept study in people with painful knee osteoarthritis (OA) aimed to determine if: (i) visuotactile illusions that manipulate perceived knee size are analgesic; (ii) cumulative analgesic effects occur with sustained or repeated illusions. Methods Participants with knee OA underwent eight conditions (order randomised): stretch and shrink visuotactile (congruent) illusions and corresponding visual, tactile and incongruent control conditions. Knee pain intensity (0–100 numerical rating scale; 0 = no pain at all and 100 = worst pain imaginable) was assessed pre- and post-condition. Condition (visuotactile illusion vs control) × Time (pre-/post-condition) repeated measure ANOVAs evaluated the effect on pain. In each participant, the most beneficial illusion was sustained for 3 min and was repeated 10 times (each during two sessions); paired t-tests compared pain at time 0 and 180s (sustained) and between illusion 1 and illusion 10 (repeated). Results Visuotactile illusions decreased pain by an average of 7.8 points (95% CI [2.0–13.5]) which corresponds to a 25% reduction in pain, but the tactile only and visual only control conditions did not (Condition × Time interaction: p = 0.028). Visuotactile illusions did not differ from incongruent control conditions where the same visual manipulation occurred, but did differ when only the same tactile input was applied. Sustained illusions prolonged analgesia, but did not increase it. Repeated illusions increased the analgesic effect with an average pain decrease of 20 points (95% CI [6.9–33.1])–corresponding to a 40% pain reduction. Discussion Visuotactile illusions are analgesic in people with knee OA. Our results suggest that visual input plays a critical role in pain relief, but that analgesia requires multisensory input. That visual and tactile input is needed for analgesia, supports multisensory modulation processes as a possible explanatory mechanism. Further research exploring the neural underpinnings of these visuotactile illusions is needed. For potential clinical applications, future research using a greater dosage in larger samples is warranted.
One step ahead: timing and sexual networks in population mobility and HIV prevention and care

Population mobility comes in heterogeneous forms and is triggered by many drivers. The diverse contexts of mobility can significantly influence the effectiveness of HIV prevention and care, as the contributions to this volume highlight. Nevertheless, some fundamental concepts are common across various forms of mobility. Two such concepts are time and sexual networks: mobility occurs in a space‐time continuum, and migrants are situated within social and sexual networks. In this viewpoint, we argue that a closer examination of how (1) time scales of mobility and (2) sexual network characteristics of migrants present challenges to effective HIV prevention can help to optimize interventions.
Inhibition of Phosphodiesterase-4 Reverses Aβ-Induced Memory Impairment by Regulation of HPA Axis Related cAMP Signaling

Beta amyloid peptides (Aβ) are found to be associated with dysfunction of hypothalamic-pituitary-adrenal axis (HPA axis) that leads to memory and cognitive deficits in patients with Alzheimer's disease (AD). Phosphodiesterase 4 (PDE4) inhibitors increase the intracellular cAMP activities, which may ameliorate cognitive deficits associated with AD. However, it remains unclear whether PDE4-mediated reversal of cognitive impairment in mouse model of AD is related to HPA axis and downstream cAMP-dependent pathway. The present study investigated the effects of PDE4 inhibitor rolipram on Aβ1-42-induced cognitive dysfunction and its underlying mechanisms. The step-down passive avoidance (PA) and Morris water-maze (MWM) tests were conducted 1 week (1 W), 2 months (2 M), and 6 months (6 M) after intracerebroventricular microjection (i.c.v.) of Aβ1-42. The results suggested that memory impairment emerged as early as 1 W, peaked at 2 M, and lasted until 6 M after injection. Chronic treatment with rolipram (0.1, 0.5, 1.0 mg/kg/d, i.p.) for 2 weeks (i.e., treatment started at 1.5 months after Aβ1-42 microinjection) dose-dependently improved memory performance in both MWM and PA tests. Moreover, rolipram reversed the Aβ-induced increases in serum corticosterone (CORT), corticotropin-releasing factor, and glucocorticoid receptors (CRF-R and GR) levels, whereas it decreases in brain-derived neurotropic factor (BDNF) and the ratio of pCREB to CREB expression. These effects of rolipram were prevented by pre-treatment with PKA inhibitor H89. The findings indicated that the protective effects of rolipram against Aβ1-42-induced memory deficits might involve HPA axis and cAMP-CREB-BDNF signaling.
Perceived Stress and Cognitive Functions Among Chinese Older Adults: The Moderating Role of Health Status

Objective: The primary purposes of the present study are (a) to investigate the stress–cognition relationship among U.S. Chinese older adults and (b) to examine the moderating role of health status on the stress–cognition relationship. Method: Data were drawn from the Population Study of Chinese Elderly in Chicago (PINE), which investigated 3,157 Chinese adults over 60 years old living in Chicago. Participants reported health status and completed the Chinese Perceived Stress Scale. Cognitive functions were measured by the East Boston Memory Test, the Digit Span Backward, the Symbol Digit Modalities Test, and Chinese Mini-Mental State Examination. Results: Controlling for age, sex, education, and income, perceived stress was negatively associated with cognitive functions, whereas health status was positively associated with cognitive functions. In addition, older adults’ health status interacted with stress such that the negative relationships between perceived stress and cognitive functions were more pronounced for those who had poor health than for those who had good health. Conclusion: Findings suggest that physical health is a critical factor moderating the relationship between perceived stress and cognitive functions among U.S. Chinese older adults. Longitudinal research is needed to examine the complex relationships among stress, health, and cognitive functions of U.S. Chinese older adults.
Fever of unknown origin following parathyroidectomy prior to onset of typical polymyalgia rheumatica symptoms: a case report

Polymyalgia rheumatica (PMR) is a disease commonly seen in elderly individuals, however, the etiology has not been reported. Typical clinical features include bilateral shoulder pain and morning stiffness, while serologic autoantibody test findings are negative. Approximately 40%–50% of affected patients present with low-grade fever, fatigue, and appetite loss, which we often experience in the field of general medicine, and thus, the condition should not be given low priority. However, knowledge regarding such constitutional manifestations is also limited. We encountered an elderly woman with a fever of unknown origin that developed following a parathyroidectomy for a single parathyroid adenoma, after which severe shoulder pain and morning stiffness emerged, leading to a diagnosis of PMR. The fever developed several days prior to appearance of severe pain, which is an uncommon presentation in PMR cases. Our patient had low-grade inflammation without pyrexia prior to the surgery, which might have been an important reason for the accelerated immoderate immune activation leading to PMR induced by surgery in this case. Furthermore, she was infected with the influenza A virus 3 weeks before coming to us. Some reports have suggested a relationship between the influenza virus or vaccine and PMR. It is difficult to conclude regarding the definite trigger in our patient, though the details of this case should be helpful for a better understanding of the disease.
Suppression of stress induction of the 78-kilodalton glucose regulated protein (GRP78) in cancer by IT-139, an anti-tumor ruthenium small molecule inhibitor

In many cancers, combination therapy regimens are successfully improving response and survival rates, but the challenges of toxicity remain. GRP78, the master regulator of the unfolded protein response, is emerging as a target that is upregulated in tumors, specifically following treatment, and one that impacts tumor cell survival and disease recurrence. Here, we show IT-139, an antitumor small molecule inhibitor, suppresses induction of GRP78 from different types of endoplasmic reticulum (ER) stress in a variety of cancer cell lines, including those that have acquired therapeutic resistance, but not in the non-cancer cells being tested. We further determined that IT-139 treatment exacerbates ER stress while at the same time suppresses GRP78 induction at the transcriptional level. Our studies revealed a differential effect of IT-139 on chaperone protein family expression at multiple levels in different cancer cell lines. In xenograft studies, IT-139 decreased BRAF inhibitor upregulation of GRP78 expression in the tumor, while having minimal effect on GRP78 expression in the adjacent normal cells. The preferential decrease in GRP78 levels in tumor cells over normal cells, supported by the manageable safety profile seen in the Phase 1 clinical trial, reinforce the value IT-139 brings to combination therapies as it continues its clinical development.
Examining scientific writing styles from the perspective of linguistic complexity

Publishing articles in high‐impact English journals is difficult for scholars around the world, especially for non‐native English‐speaking scholars (NNESs), most of whom struggle with proficiency in English. To uncover the differences in English scientific writing between native English‐speaking scholars (NESs) and NNESs, we collected a large‐scale data set containing more than 150,000 full‐text articles published in PLoS between 2006 and 2015. We divided these articles into three groups according to the ethnic backgrounds of the first and corresponding authors, obtained by Ethnea, and examined the scientific writing styles in English from a two‐fold perspective of linguistic complexity: (a) syntactic complexity, including measurements of sentence length and sentence complexity; and (b) lexical complexity, including measurements of lexical diversity, lexical density, and lexical sophistication. The observations suggest marginal differences between groups in syntactical and lexical complexity.
How Universal Is the General Factor of Personality? An Analysis of the Big Five in Forager Farmers of the Bolivian Amazon

In various personality models, such as the Big Five, a consistent higher order general factor of personality (GFP) can be identified. One view in the literature is that the GFP reflects general social effectiveness. Most GFP studies, however, have been conducted in Western, educated, industrialized, and rich democracies (WEIRD). Therefore, to address the question of the universality of the GFP, we test whether the GFP can also be identified in a preliterate indigenous sample of Tsimane by using self-reports, spouse reports, and interviewer ratings. In the Tsimane, a viable GFP could be identified and the intercorrelations between personality traits were significantly stronger than in samples from industrial countries. The GFP correlated with the ratings of social engagement. In addition, self and spouse ratings of the GFP overlapped. Overall, the findings are in line with the notion that the GFP is a human universal and a substantive personality factor reflecting social effectiveness.
Radiosensitivity enhancement by combined treatment of nimotuzumab and celecoxib on nasopharyngeal carcinoma cells

Introduction In this study, the radiation-enhancing effects of combined treatment with nimotuzumab, a humanized EGFR-blocking antibody, and celecoxib, a COX-2 selective inhibitor, in human nasopharyngeal carcinoma (NPC) cells were investigated. Materials and methods 3-(4,5-Dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide and clonogenic survival assays were done to evaluate the combined cytotoxic and radiosensitizing effects of nimotuzumab or celecoxib or the combination on CNE1 and CNE2 cells. Western blot analysis was performed to identify the effect of nimotuzumab and/or celecoxib with or without irradiation on the cytoplasmic and nuclear EGFR signaling pathways in CNE2 cells. Results Our results demonstrated that concurrent administration of nimotuzumab and celecoxib cooperatively enhanced the cytotoxicity and radiosensitivity of CNE2 cells but not CNE1 cells. The combination of both drugs with or without irradiation also cooperatively inhibited cytoplasmic and nuclear EGFR signaling pathways in CNE2 cells. Conclusion Our results suggest a promising approach for the treatment of poorly differentiated NPC.
Environmental Enrichment and Successful Aging

The human brain sustains a slow but progressive decline in function as it ages and these changes are particularly profound in cognitive processing. A potential contributor to this deterioration is the gradual decline in the functioning of multiple sensory systems and the effects they have on areas of the brain that mediate cognitive function. In older adults, diminished capacity is typically observed in the visual, auditory, masticatory, olfactory, and motor systems, and these age-related declines are associated with both a decline in cognitive proficiency, and a loss of neurons in regions of the brain. We will review how the loss of hearing, vision, mastication skills, olfactory impairment, and motoric decline accompany cognitive loss, and how improved functioning of these systems may aid in the restoration of the cognitive abilities in older adults. The human brain appears to require a great deal of stimulation to maintain its cognitive efficacy as people age and environmental enrichment may aid in its maintenance and recovery.
Event-Related Potentials Measured From In and Around the Ear Electrodes Integrated in a Live Hearing Device for Monitoring Sound Perception

Future hearing devices could exploit brain signals of the user derived from electroencephalography (EEG) measurements, for example, for fitting the device or steering signal enhancement algorithms. While previous studies have shown that meaningful brain signals can be obtained from ear-centered EEG electrodes, we here present a feasibility study where ear-EEG is integrated with a live hearing device. Seventeen normal-hearing participants were equipped with an individualized in-the-ear hearing device and an ear-EEG system that included 10 electrodes placed around the ear (cEEGrid) and 3 electrodes spread out in the concha. They performed an auditory discrimination experiment, where they had to detect an audible switch in the signal processing settings of the hearing device between repeated presentations of otherwise identical stimuli. We studied two aspects of the ear-EEG data: First, whether the switches in the hearing device settings can be identified in the brain signals, specifically event-related potentials. Second, we evaluated the signal quality for the individual electrode positions. The EEG analysis revealed significant differences between trials with and without a switch in the device settings in the N100 and P300 range of the event-related potential. The comparison of electrode positions showed that the signal quality is better for around-the-ear electrodes than for in-concha electrodes. These results confirm that meaningful brain signals related to the settings of a hearing device can be acquired from ear-EEG during real-time audio processing, particularly if electrodes around the ear are available.
Anaphase Chromosomes in Crane-Fly Spermatocytes Treated With Taxol (Paclitaxel) Accelerate When Their Kinetochore Microtubules Are Cut: Evidence for Spindle Matrix Involvement With Spindle Forces

Various experiments have indicated that anaphase chromosomes continue to move after their kinetochore microtubules are severed. The chromosomes move poleward at an accelerated rate after the microtubules are cut but they slow down 1–3 min later and move poleward at near the original speed. There are two published interpretations of chromosome movements with severed kinetochore microtubules. One interpretation is that dynein relocates to the severed microtubule ends and propels them poleward by pushing against non-kinetochore microtubules. The other interpretation is that components of a putative “spindle matrix” normally push kinetochore microtubules poleward and continue to do so after the microtubules are severed from the pole. In this study we distinguish between these interpretations by treating cells with taxol. Taxol eliminates microtubule dynamics, alters spindle microtubule arrangements, and inhibits dynein motor activity in vivo. If the dynein interpretation is correct, taxol should interfere with chromosome movements after kinetochore microtubules are severed because it alters the arrangements of spindle microtubules and because it blocks dynein activity. If the “spindle matrix” interpretation is correct, on the other hand, taxol should not interfere with the accelerated movements. Our results support the spindle matrix interpretation: anaphase chromosomes in taxol-treated crane-fly spermatocytes accelerated after their kinetochore microtubules were severed.