Miracle-dz/UniFAR-FTUs huggingface dataset:
Acute poisoning among children admitted to a regional university hospital in Northern Greece.

OBJECTIVES The aim of our study was to elucidate the current pattern of acute poisoning among children admitted to a regional University Hospital in the prefecture of Evros in Northern Greece. We also compared the obtained findings with those of two previous studies performed in the same region. METHODS Demographic and clinical data, management, and outcome of children with acute poisoning were recorded in our region, during the past 5-years (2005-2009, period C) and compared to similar studies carried out in the periods 1985-1989 (period A) and 1995-1999 (period B). RESULTS Comparison between the three periods showed that in period Athe lower incidence of children's acute poisoning (CAP) was observed. Also this revealed a 20%-reduction in the frequency of poisoning over the past 5-years (period C) compared to period B (p = 0.219), a significant increase in tobacco intoxication over the years (in the order A-C; p < 0.001 for comparisons of periods A and B, and periods B and C), while poisoning from insecticides-pesticides decreased (p < 0.001). The incidence of poisoning via salicylates significantly reduced from 9.7% in period A to 6.2% in period B, and further to 4.7% in period C (p = 0.016), whereas during the same periods poisoning via paracetamol increased from 2.3% to 5.1% and then to 10.4%, respectively (p < 0.001). Atrend toward a higher incidence of suicide attempt via poisoning was found during the three periods (from 3.0% in period A to 4.7% and 6.6%, in periods B and C, respectively; p = 0.049). CONCLUSIONS The frequency of acute poisoning among children has decreased over the past 5 years. The incidences of poisoning via paracetamol and tobacco, and attempted suicide have increased in recent years. Targeted and continuous educational preventive programs are mandatory.
Development of high efficiency rectification circuit for mW-class rectenna

For applications of the microwave power transmission technology, it is necessary to realize high efficiency rectennas or rectification circuits. Especially, RF-ID's or ubiquitous power sources demand high RF-DC conversion efficiency for below mW microwave inputs. However, almost all past rectennas or rectification circuits were designed for over 100mW rectifying and the RF-DC conversion efficiencies were less than 20% at 1mW microwave input. In this paper, we investigate rectification circuits for developing mW-class rectennas. Discussing diode mount structures in order to increase the efficiency below 10mW microwave input, we succeeded in developing a rectification circuit whose efficiency is 62.8% for a 10mW microwave input. We also find that approximately 30% of the input microwave power is consumed by the diode in the rectification circuit.
Independence of pituitary tumor-mediated suppression of growth hormone secretion and cyclic 3',5'-adenosine monophosphate production.

Summary Cyclic adenosine 3′,5′-monophosphate (cyclic AMP) increases the in vitro release of growth hormone by normal pituitary glands. Growth hormone-secreting pituitary tumors in rats are known to inhibit synthesis of growth hormone by the pituitary glands of the hosts. Studies were initiated to determine whether the tumors exerted their effects on the glands by a mechanism involving cyclic AMP. No difference in adenyl cyclase was found between the glands of tumor-bearing animals and those of normal animals. When adenyl cyclase was measured in the presence of 10 mm NaF, enzyme activity in both normal glands and glands of tumor animals was stimulated 500%. Cyclic AMP phosphodiesterase activity in the glands of rats bearing hormone-secreting tumors was significantly greater than in control glands, but no differences in cyclic AMP levels were found in the glands. Dibutyryl cyclic AMP stimulated the in vitro release of newly synthesized growth hormone from glands of both normal and tumor-bearing animals. Similarly, the in vitro release of growth hormone by control glands and by glands of tumor animals was stimulated by the presence of 0.1 µm prostaglandin E 1 . It is concluded that growth hormone-secreting pituitary tumors exert their effects on the pituitary glands of the host animals by mechanisms that are independent of cyclic AMP production.
K-means clustering based filter feature selection on high dimensional data

With hundreds or thousands of features in high dimensional data, computational workload is challenging. In classification process, features which do not contribute significantly to prediction of classes, add to the computational workload. Therefore the aim of this paper is to use feature selection to decrease the computation load by reducing the size of high dimensional data. Selecting subsets of features which represent all features were used. Hence the process is two-fold; discarding irrelevant data and choosing one feature that representing a number of redundant features. There have been many studies regarding feature selection, for example backward feature selection and forward feature selection. In this study, a k-means clustering based feature selection is proposed. It is assumed that redundant features are located in the same cluster, whereas irrelevant features do not belong to any clusters. In this research, two different high dimensional datasets are used: 1) the Human Activity Recognition Using Smartphones (HAR) Dataset, containing 7352 data points each of 561 features and 2) the National Classification of Economic Activities Dataset, which contains 1080 data points each of 857 features. Both datasets provide class label information of each data point. Our experiment shows that k-means clustering based feature selection can be performed to produce subset of features. The latter returns more than 80% accuracy of classification result.
Biological Effectiveness of Ionizing Radiation : Acute vs . Protracted Exposures

This letter refers to the current discussion around re-evaluation of the dose and dose rate effectiveness factor (DDREF) equal to 2, presently recommended by the International Commission on Radiological Protection. The topics of the threshold, hormesis and DDREF are interrelated with the linear no-threshold theory (LNT). The LNT does not take into account that DNA damage and repair are permanent processes in dynamic equilibrium. Given the evolutionary prerequisite of best fitness, it would be reasonable to assume that living organisms have been adapted by the natural selection to the background levels of ionizing radiation. Accordingly, there must be an optimal exposure level, as it is for many environmental factors. Several studies cited in the literature in support of the LNT and lowering of the DDREF down to 1 are discussed here. In the author’s opinion, the dose-effect relationships with non-neoplastic diseases found in certain exposed populations call in question dose-effect relationships with cancer. Self-selection and other biases in epidemiological studies are discussed. The dose-response relationships should be clarified in largescale experiments involving different animal species. In conclusion, the LNT and under-estimation of DDREF tend to exaggerate radiationrelated health risks at low radiation doses and dose rates.
EFFECT OF ICE BAG, DYNAMIC STRETCHING AND COMBINED TREATMENTS ON THE PREVENTION AND TREATMENT OF DELAY ONSET MUSCLE SORENESS

ABSTRACTINTRODUCTION Address for correspondence: Dr. Warin Krityakiarana, PhD, PT. Division of Physical Therapy, Facultyof Health Science, Srinakharinwirot University, Ongkharak, Nakhon-Nayok, 26120. Thailand. Phone:(+66) 02649 5447-9 ext 234, Fax: (+66) 02649 5450 E-Mail: warink@swu.ac. th International Journal of Physiotherapy and Research,Int J Physiother Res 2014, Vol 2(6):799-05. ISSN 2321-1822DOI: 10.16965/ijpr.2014. 696 EFFECT OF ICE BAG, DYNAMIC STRETCHING AND COMBINEDTREATMENTS ON THE PREVENTION AND TREATMENT OF DELAYONSET MUSCLE SORENESS Delayed onset muscle soreness (DOMS) is aphenomenon that arises from physical exertionand described as unpleasant sensation or painafter unaccustomed strenuous exercise. Sportsmedicine professionals use various forms of coldapplication and stretching on a daily basis toprevent and treat DOMS. The onset of DOMSoccurs 8 to 24 hours post-exercise. It is essen-tial that these clinicians know about thephysiologic effects of cold and stretching inorder to provide the most appropriateapplication protocols for athletes. Thephysiologic effects of cryotherapy are decreasesin metabolism, inflammation, pain, and musclespasm
GIC in Future Large-Scale Power Grids: An analysis of the problem.

The power grid is the spine of the energy revolution and social progress. With microgrid technology gradually coming into maturity and offshore wind power continuously developing, the development of the future power grid will be the result of the combination of an ultralarge-scale backbone grid and distributed microgrids. Microgrids will be the power supplies for families, schools, and tourism areas, while the large-scale grid will be responsible for the power supply for industrial areas, large- and medium-sized cities, and large areas with developed economies.
Mechanism of Resveratrol-mediated Suppression of Tissue Factor Gene Expression

Summary Tissue factor (TF) is a cell surface receptor for factor VII(a), and the binding of factor VII(a) to TF initiates the coagulation cascade. Inappropriate in vivo expression of TF in vascular cells has been shown to be responsible for thrombotic disorders associated with a variety of pathological conditions, including gram-negative sepsis, cancer and atherosclerosis. A number of epidemiological studies suggest that moderate consumption of red wine provides protective effects against coronary heart disease mortality. Recently, we have shown that resveratrol, a polyphenolic compound found in wine, inhibited the induction of TF expression in endothelial cells and mononuclear cells (Pendurthi UR, Williams JT, Rao LVM. Arterioscler Thromb Vasc Biol 1999; 19: 419-426). In the present study, we examined the mechanism by which resveratrol inhibits the expression of TF in monocytes by using a monocytic cell line, THP-1, as a model cell. Northern blot analysis, gel mobility shift assays and transfection studies with various TF promoter constructs, as well as other transcription regulatory constructs, were used to elucidate the inhibitory mechanism of resveratrol. The data show that resveratrol inhibited lipopolysaccharide (LPS)-induced expression of TF in human monocytes and monocytic cell line, THP-1 in a dose dependent manner. Resveratrol did not significantly alter the binding of various transcription factors involved in TF gene expression to DNA. However, resveratrol suppressed the transcription of cloned human TF promoter. Further experiments revealed that resveratrol reduced κB- but not AP-1-driven transcriptional activity. Additional experiments showed that resveratrol suppressed the phosphorylation of p65 and its transactivation. In summary, our results indicate that resveratrol does not inhibit the activation or translocation of NF-κB/Rel proteins but inhibits NF-κB/Rel-dependent transcription by impairing the transactivation potential of p65.
Emerging Roles of Ruk/CIN85 in Vesicle‐Mediated Transport, Adhesion, Migration and Malignancy

Ruk/CIN85 is an adaptor protein. Similar to many other proteins of this type, Ruk/CIN85 is known to take part in multiple cellular processes including signal transduction, vesicle‐mediated transport, cytoskeleton remodelling, programmed cell death and viral infection. Recent studies have also revealed the potential importance of Ruk/CIN85 in cancer cell invasiveness. In this review we summarize the various roles of this protein as well as the potential contribution of Ruk/CIN85 to malignancy and the invasiveness of cancer cells. In the last section of the paper we also speculate on the utility of Ruk/CIN85 as a target for novel anti‐cancer therapies.
RENAL FUNCTION IN MICE POISONED WITH ORAL URANIUM AND TREATED WITH ETHANE-1-HYDROXY-1,1-BISPHOSPHONATE (EHBP)

Abstract— Exposure to uranium is a risk for the workers involved in uranium mining, purification, and manufacture, principally by its ingestion or inhalation. It is also a risk for the population at large in case of intake of contaminated water or food. Uranium induces nephropathy that is characteristic of heavy metals, which can lead to death. The toxic effects of uranium can be prevented by a biphosphonate, ethane-1-hydroxy-1,1-bisphosphonate (bisodic etidronate), administered orally or subcutaneously. Employing bisodic etidronate, our laboratory obtained satisfactory results in terms of survival in adult mice, adult rats, and suckling rats. The aim of the present study was to evaluate the efficacy of bisodic etidronate for preventing renal dysfunction induced by a lethal dose of uranyl nitrate, employing serum levels of urea and creatinine as end-points. Two experiments were performed over different time periods, i.e., Experiment A: 48 h, Experiment B: 14 d. Each experiment was performed with 4 groups of 20 male Balb/c mice each, 25 g average body weight. Three of these groups received 350 mg kg−1 of body weight of uranyl nitrate by gavage (forced oral administration). Two of the three exposed groups were treated with bisodic etidronate either by gavage in a dose of 500 mg kg−1 body weight or with a subcutaneous injection of 50 mg kg−1 body weight. The fourth group served as control. Survivors of the experimental groups were sacrificed at the end of the experiment by overdose of inhalation anesthetic (ether). The kidneys were routinely processed for histological analysis. Blood samples were taken by cardiac puncture to assess urea and creatinine serum levels. Urea and creatinine serum levels were markedly lower at 48 h in exposed animals treated with bisodic etidronate than in untreated exposed animals. On day 14 these values in exposed and treated animals did not differ significantly from control values. The renal function of animals treated with orally or subcutaneous bisodic etidronate that survived uranyl nitrate exposure was markedly improved compared to the controls of untreated exposed animals at 48 h. At 14 days, treatment with bisodic etidronate averted renal damage. At this time, the histologic study of kidneys showed images of tissue recovery. These results suggest that the use of EHBP may be of great value in reducing the renal damage.
Effect of different positively charged amino acids, C-terminally of the signal peptidase cleavage site, on the translocation kinetics of a precursor protein in Escherichia coli K-12.

Introduction of positively charged amino acids immediately downstream of the signal sequence in prokaryotic precursor proteins is known to affect the export process. However, it is not clear whether different positively charged amino acids affect the export process similarly. To investigate this, the glutamate at position +2 of outer membrane protein PhoE was substituted by arginine, lysine or histidine. Pulse-chase experiments revealed that the Lys and Arg residues at position +2 caused a reduced processing rate, and that the effect was markedly more severe in the case of the Arg residue. Trypsin accessibility experiments revealed that the accumulated precursors were present in the cytoplasm. Since the degree of the inhibitory effect corresponded to the pKa of the different positively charged amino acids, this suggests that the positively charged residues must be deprotonated during the secretory process.
TRIM family proteins: emerging class of RING E3 ligases as regulator of NF‐κB pathway

The nuclear factor κB (NF‐κB) transcription factor family plays a key role in regulation of the inflammatory pathway in response to different physiological stimuli starting from development to ageing. The dysregulation of NF‐κB has been associated with many pathological conditions like inflammatory diseases, neurodegeneration, metabolic diseases and various kinds of malignancies. The NF‐κB pathway is regulated by number of post‐translational modifications, including phosphorylation and ubiquitination. Ubiquitin (Ub) E3 ligases are key regulators of the process of ubiquitination and provide specificity to the pathway as they recognise the substrate and determine the topology of ubiquitination. TRIMs, members of RING family of Ub E3 ligases, are characterised by the presence of three conserved domains, RING, B‐Box and coiled‐coil (RBCC). Emerging evidence suggests that TRIMs regulate innate immune signalling during infection and different pathological conditions. The studies have demonstrated the role of TRIMs in regulation of inflammatory pathways including NF‐κB. Recent reports suggest that TRIMs play a critical role in regulation of the NF‐κB pathway by ubiquitinating proteins at different steps. In the current review, we discuss the role of TRIMs as novel NF‐κB regulators and their role in different pathophysiological conditions.
Effect of Dual Blockade of Renin-Angiotensin Aldosterone System On Proteinuria In Patients With Diabetic Nephropathy and Advanced Azotemia

Purpose : To investigate the dual effect of angiotensin blockade by irbesartan and enalapril on proteinuria in diabetic patients with azotemia. Methods : Patients with diabetes of > 5 years duration, proteinuria at a nephrotic level and serum creatinine > 1.5 mg/dL were enrolled in the study. Forty-five enrolled patients were divided into three groups, those receiving enalapril , irbesartan, or enalapril plus irbesartan, respectively, over a period of 24 weeks. Urinary protein excretion and serum level of albumin, creatinine, potassium were measured before and after treatment Results : In patients receiving enalapril, irbesartan, and both drugs concomitantly, mean urinary protein excretion level decreased significantly at the end of 6 months from 6.46 ± 4.66 to 3.36 ± 1.60, 5.89 ± 5.34 to 3.22 ± 1.72 and 5.99 ± 3.77 to 2.10 ± 2.22 g/day, respectively (p = 0.001). Decrease in proteinuria in the group receiving the combined therapy was more significant than the other two groups (p = 0.025). During the period of therapy, serum albumin increased and mean arterial pressure decreased significantly (p = 0.02 and p = 0.002, respectively) but serum creatinine and potassium and creatinine clearance values showed insignificant increases (p = 0.28 and p = 0.57, respectively). Conclusion : The combined use of enalapril and irbesartan, in patients with diabetic nephropathy associated with azotemia, is more effective in decreasing proteinuria without causing any substantial increase in serum potassium levels. The combined use of these two drugs shows a more pronounced anti-proteinuric effect. Keywords : Angiotensin-converting enzyme inhibitor, Angiotensin receptor blocker, Diabetic nephropathy, Azotemia, Proteinuria, Aldosterone, Renin, Blood pressure
Do Narcissism and Emotional Intelligence Win Us Friends? Modeling Dynamics of Peer Popularity Using Inferential Network Analysis

This research investigated effects of narcissism and emotional intelligence (EI) on popularity in social networks. In a longitudinal field study, we examined the dynamics of popularity in 15 peer groups in two waves (N = 273). We measured narcissism, ability EI, and explicit and implicit self-esteem. In addition, we measured popularity at zero acquaintance and 3 months later. We analyzed the data using inferential network analysis (temporal exponential random graph modeling, TERGM) accounting for self-organizing network forces. People high in narcissism were popular, but increased less in popularity over time than people lower in narcissism. In contrast, emotionally intelligent people increased more in popularity over time than less emotionally intelligent people. The effects held when we controlled for explicit and implicit self-esteem. These results suggest that narcissism is rather disadvantageous and that EI is rather advantageous for long-term popularity.
An ER packaging chaperone determines the amino acid uptake capacity and virulence of Candida albicans

The Candida albicans CSH3 gene encodes a functional and structural homologue of Shr3p, a yeast protein that is specifically required for proper uptake and sensing of extracellular amino acids in Saccharomyces cerevisiae. A Candida csh3Δ/csh3Δ null mutant has a reduced capacity to take up amino acids, and is unable to switch morphologies on solid and in liquid media in response to inducing amino acids. CSH3/csh3Δ heterozygous strains display normal amino acid induced morphological switching. However, although heterozygous cells apparently sense and properly react to amino acid induced signals they cannot take up amino acids at wild‐type rates. Strikingly, both CSH3/csh3Δ heterozygous and csh3Δ/csh3Δ homozygous strains are unable to efficiently mount virulent infections in a mouse model. The haploinsufficiency phenotypes indicate that both CSH3 alleles contribute to maintain high‐capacity amino acid uptake in wild‐type strains. These results strongly suggest that C. albicans cells use amino acids, presumably as nitrogen sources, during growth in mammalian hosts.
Recapitulation of Embryological Programmes in Renal Fibrosis – The Importance of Epithelial Cell Plasticity and Developmental Genes

Chronic fibrosis represents the final common pathway in progressive renal disease. Myofibroblasts deposit the constituents of renal scar, thus crippling renal function. It has recently emerged that an important source of these pivotal effector cells is the injured renal epithelium. This review concentrates on the process of epithelial-mesenchymal transition (EMT) and its regulation. The role of the developmental gene, gremlin, which is reactivated in adult renal disease, is the subject of particular focus. This member of the cysteine knot protein superfamily is critical to the process of nephrogenesis but quiescent in normal adult kidney. There is increasing evidence that gremlin expression reactivates in diabetic nephropathy, and in the diseased fibrotic kidney per se. Known to antagonize members of the bone morphogenic protein (BMP) family, gremlin may also act downstream of TGF-β in induction of EMT. An increased understanding of the extracellular modulation of EMT and, in particular, of the gremlin-BMP axis may result in strategies that can halt or reverse the devastating progression of chronic renal fibrosis.
Legal Work and the Glass Cliff: Evidence that Women are Preferentially Selected to Lead Problematic Cases

Recent archival and experimental research by Ryan and Haslam has revealed the phenomenon of the glass cliff whereby women are more likely than men to be appointed to risky or precarious leadership positions in problematic organizational circumstances. This paper extends research on the glass cliff by examining the precariousness of the cases women are assigned in a legal context. An experimental study conducted with law students (N = 114) investigated the appointment of a candidate to lead a legal case that was defined as either low-risk or high-risk. Commensurate with patterns observed in other domains, results indicated that a male candidate was as likely as a female to be selected as lead counsel for a low-risk case but that there was a strong preference for a female rather than a male appointment for a high-risk case. The study also examines the way in which participants' evaluations of candidates and their perceptions of risk and opportunity related to candidate selection. Implications and directions for future research are discussed.