Miracle-dz/UniFAR-FTUs huggingface dataset:
Using the refined ICF Linking Rules to compare the content of existing instruments and assessments: a systematic review and exemplary analysis of instruments measuring participation

Abstract Background: Existing instruments measuring participation may vary with respect to various aspects. This study aimed to examine the comparability of existing instruments measuring participation based on the International Classification of Functioning, Disability and Health (ICF) by considering aspects of content, the perspective adopted and the categorization of response options. Methods: A systematic literature review was conducted to identify instruments that have been commonly used to measure participation. Concepts of identified instruments were then linked to the ICF following the refined ICF Linking Rules. Aspects of content, perspective adopted and categorization of response options were documented. Results: Out of 315 instruments identified in the full-text screening, 41 instruments were included. Concepts of six instruments were linked entirely to the ICF component Activities and Participation; of 10 instruments still 80% of their concepts. A descriptive perspective was adopted in most items across instruments (75%), mostly in combination with an intensity rating. An appraisal perspective was found in 18% and questions from a need or dependency perspective were least frequent (7%). Conclusion: Accounting for aspects of content, perspective and categorization of responses in the linking of instruments to the ICF provides detailed information for the comparison of instruments and guidance on narrowing down the choices of suitable instruments from a content point of view. Implications for Rehabilitation For clinicians and researchers who need to identify a specific instrument for a given purpose, the findings of this review can serve as a screening tool for instruments measuring participation in terms of the following: • Their content covered based on the ICF. • The perspective adopted in the instrument (e.g., descriptive, need/dependency or appraisal). • The categorization of their response options (e.g., intensity or frequency).
More than Just Worksheets?: A Study of the Confidence of Newly Qualified Teachers of English in Teaching Personal, Social and Health Education in Secondary Schools

Abstract This paper addresses concerns regarding the preparedness of newly qualified teachers to deliver Personal, Social and Health Education (PSHE) in the United Kingdom in relation to the training received during Initial Teacher Education and through early Continuing Professional Development. The paper is situated not only within a context where OfSTED has questioned the adequacy of some non-specialist PSHE teachers but also one where, due to a range of social and health concerns centred on young people, schools and teachers are being expected to play an increasingly important role in the social and health education of their pupils. As such, PSHE is increasingly seen as important across all curriculum areas. This paper relates specifically to the confidence of trainee and newly qualified teachers of English in teaching PSHE in secondary schools in the United Kingdom. Drawing on questionnaire data collected from recent Professional Graduate Certificate in Education graduates, the paper suggests that trainee and newly qualified teachers have the skills and knowledge drawn from their main subject (English) to deliver PSHE; however, many lack confidence and awareness to acknowledge these skills. The paper suggests that this situation may be addressed through increased opportunity to deliver and receive feedback on PSHE teaching during initial teacher training.
Expression of NeuGc on Pig Corneas and Its Potential Significance in Pig Corneal Xenotransplantation

Purpose: Pigs expressing neither galactose-&agr;1,3-galactose (Gal) nor N-glycolylneuraminic acid (NeuGc) take xenotransplantation one step closer to the clinic. Our aims were (1) to document the lack of NeuGc expression on corneas and aortas and cultured endothelial cells [aortic endothelial cells (AECs); corneal (CECs)] of GTKO/NeuGcKO pigs, and (2) to investigate whether the absence of NeuGc reduced human antibody binding to the tissues and cells. Methods: Wild-type (WT), GTKO, and GTKO/NeuGcKO pigs were used for the study. Human tissues and cultured cells were negative controls. Immunofluorescence staining was performed using anti-Gal and anti-NeuGc antibodies, and human IgM and IgG binding to tissues was determined. Flow cytometric analysis was used to determine Gal and NeuGc expression on cultured CECs and AECs and to measure human IgM/IgG binding to these cells. Results: Both Gal and NeuGc were detected on WT pig corneas and aortas. Although GTKO pigs expressed NeuGc, neither humans nor GTKO/NeuGcKO pigs expressed Gal or NeuGc. Human IgM/IgG binding to corneas and aortas from GTKO and GTKO/NeuGcKO pigs was reduced compared with binding to WT pigs. Human antibody binding to GTKO/NeuGcKO AECs was significantly less than that to GTKO AECs, but there was no significant difference in binding between GTKO and GTKO/NeuGcKO CECs. Conclusions: The absence of NeuGc on GTKO aortic tissue and AECs is associated with reduced human antibody binding, and possibly will provide a better outcome in clinical xenotransplantation using vascularized organs. For clinical corneal xenotransplantation, the absence of NeuGc expression on GTKO/NeuGcKO pig corneas may not prove an advantage over GTKO corneas.
Long‐term prognostic impact of the use of erythropoietic‐stimulating agents in patients with chronic myeloid leukemia in chronic phase treated with imatinib

Anemia is a frequent side effect of imatinib in patients with chronic myeloid leukemia (CML). Erythropoietic‐stimulating agents have been used for treatment of imatinib‐induced anemia. There are no data on long‐term safety of erythropoietic‐stimulating agents in CML patients.
Malnutrition identification, diagnosis and dietetic referrals: Are we doing a good enough job?

Aim: To determine the prevalence and diagnosis, documentation and referral rates for malnutrition among hospitalised patients and to ascertain potential shortfalls in financial reimbursement to a hospital as a result of malnutrition misdiagnosis. Methods: The Subjective Global Assessment tool was used to assess the nutritional status of 275 randomly selected inpatients on admission over a five-week period across the acute care wards of a metropolitan tertiary teaching hospital. A retrospective audit of malnourished patients' medical histories was performed to assess diagnosis, documentation and dietetic referral rates for malnutrition. Where malnutrition was not included in the coding of an admission, that admission was hypothetically recoded to determine whether it changed the Diagnosis Related Group and subsequently the payment allocated for that admission. Results: Prevalence of malnutrition was 23%. Malnourished patients had significantly longer lengths of stay by 4.5 days compared with well-nourished patients (P < 0.001). Only 15% of malnourished patients were correctly identified and documented as such in the medical histories. A dietitian was involved in 45% of malnutrition cases, but only documented 29% of such cases as malnourished. Forty-eight of 53 (91%) audited cases did not have the corresponding malnutrition code included in their Diagnosis Related Group, resulting in a shortfall of AU$27 617 to the hospital in reimbursements, and AU$1 850 540 when extrapolated across the financial year. Conclusion: Malnutrition is highly prevalent in the acute hospital setting, yet remains poorly identified and formally documented. Many patients are not referred for dietetic intervention, thus compromising their clinical outcomes. Poor documentation of malnutrition can further result in financial shortfalls to the hospital.
Activation of the phosphoinositide‐3‐kinase and mammalian target of rapamycin signaling pathways are associated with shortened survival in patients with malignant peritoneal mesothelioma

Malignant peritoneal mesothelioma (MPM) is a rare malignancy of the serosal membranes of the abdominal cavity. This cancer is ultimately fatal in almost all afflicted individuals; however, there is marked variability in its clinical behavior: Some patients die rapidly, and others survive for many years. In the current study, the authors investigated the molecular nature of MPM to obtain insights into the heterogeneity of its clinical behavior and to identify new therapeutic targets for intervention.
In the Eye of the Beholder—Skin Rejuvenation Using a Light‐Emitting Diode Photomodulation Device

BACKGROUND A light‐emitting diode (LED) photomodulation system can produce pulses of amber light expected to induce structural skin changes and reverse the effects of photoaging. OBJECTIVE To reproduce the encouraging results already published. METHODS AND MATERIALS Facial skin was exposed to pulses of 588±10‐nm‐wavelength light from a photomodulation device for 40 seconds once a week for 8 weeks. Photographs, clinical assessment, and a subjective questionnaire were taken at baseline, at the last follow‐up, and 1 month after that. Thirty‐six patients' pre‐ and post‐treatment photos were arbitrarily scrambled, and 30 independent blinded observers were asked to pick the post‐treatment photo. Two time‐point comparisons were evaluated. RESULTS For every facial characteristic studied and for both time‐point comparisons, patients reported highly statistically significant improvements. In extremely sharp contrast, neither the physician's assessment nor the independent observers' evaluation indicated any improvement. CONCLUSION Although subjective findings are comparable between studies, we were unable to reproduce the objective results of efficacy previously reported. Patients genuinely believed that several of their facial features had improved, even though there was no detectable objective change. Our data therefore suggest that the LED photomodulation treatment from the device tested is a placebo. The authors have indicated no significant interest with commercial supporters.
Randomized controlled trial of a web-based multi-modal therapy program for executive functioning in children and adolescents with unilateral cerebral palsy

Abstract Purpose state: Determine the efficacy of Move-it-to-improve-it (Mitii™), a multi-modal web-based program, in improving Executive Function (EF) in children with unilateral cerebral palsy (UCP). Method: Participants (n = 102) were matched in pairs then randomized to: intervention (Mitii™ for 20 weeks; n = 51; 26 males; mean age = 11 years 8 months (SD = 2 years 4 months); Full Scale IQ = 84.65 (SD = 15.19); 28 left UCP; GMFCS-E&R (I = 20, II = 31) or waitlist control (n = 50; 25 males; mean age = 11 years 10 months (SD = 2 years 5 months); Full Scale IQ = 80.75 (SD = 19.81); 20 left UCP; GMFCS-E&R (I = 25, II = 25). Mitii™ targeted working memory (WM), visual processing (VP), upper limb co-ordination and physical activity. EF capacity was assessed: attentional control (DSB; WISC-IV); cognitive flexibility (inhibition and number-letter sequencing DKEFS); goal setting (D-KEFs Tower Test); and information processing (WISC-IV Symbol Search and Coding). EF performance was assessed via parent report (BRIEF). Groups were compared at 20 weeks using linear regression (SPSS 21). Results: There were no significant between group differences in attentional control (DSB; p = 0.20;CI= −0.40,1.87); cognitive flexibility (Inhibition, p = 0.34; CI= −0.73,2.11; number/letter sequencing, p = 0.17; CI= −0.55,2.94); problem solving (Tower; p = 0.28; CI= −0.61,2.09), information processing (Symbol; p = 0.08; CI= −0.16, 2.75; Coding; p = 0.07; CI= −0.12,2.52) or EF performance (p = 0.13; CI= −10.04,1.38). Conclusion:In a large RCT, MitiiTM did not lead to significant improvements on measures of EF or parent ratings of EF performance in children with UCP. Implications for rehabilitation A large RCT of the multi-modal web based training; Move It to Improve It (MitiiTM) improves motor processing, visual perception, and physical capacity but does demonstrate statistically significant improvements or clinical significance in executive function in children with mild to moderate unilateral cerebral palsy (UCP). MitiiTM training completed by an intervention group was highly variable with few children reaching the target dosage of 60 h. Technical issues including server and internet connectively problems lead to disengagement with the program. Web-based training delivered in the home has the potential to increase therapy dose and accessibility, however, MitiiTM needs to be tailored to include tasks involving goal-setting, more complex problem solving using multi-dimensional strategies, mental flexibility, switching between two cognitively demanding tasks, and greater novelty in order to increase the cognitive component and challenge required to drive changes in EF.
Changes in return to work among patients in vocational rehabilitation: a self-determination theory perspective

Abstract Purpose: The aim of the current study was to examine whether patient perceptions of autonomy support from the treatment team in a vocational rehabilitation program will be associated with change (increase) in need satisfaction, autonomous motivation, perceived competence, well-being, physical activity, and return to work (RTW), and whether the self-determination theory (SDT) Model of Health Behavior will provide adequate fit to the data. Method: A total of 90 participants were enrolled in a longitudinal study and completed measures at four time points over 15 months. Results: Participants reported increases in all variables, and in general these changes were maintained at six weeks post-rehabilitation and at 15 months post-baseline. As well, the SDT Model of Health Behavior provided adequate fit to the data. Conclusions: These results underscore the importance of health care practitioners’ providing support for their patients’ autonomy, competence, and relatedness to improve well-being, physical activity, and RTW in the context of vocational rehabilitation. Implications for Rehabilitation Vocational rehabilitation that emphasizes physical activity is associated with increases in patients’ well-being, physical activity, and return to work (RTW). It is important for health care practitioners to provide support for their patients’ autonomy, competence, and relatedness in the context of vocational rehabilitation, as doing so is associated with increases in patients’ autonomous motivation, perceived competence, and psychosocial outcomes.
Risk factors for failure to enter vocational rehabilitation services among individuals with disabilities

Abstract Purpose: To investigate the risk factors for failure of individuals with disabilities to enter the vocational rehabilitation (VR) programme, including the cases where they had been formally accepted but were yet to receive any service. Methods: We used prospective cohort data from a Midwestern US state, and analysed 126,251 and 94,517 individuals, respectively, for acceptance and admission into VR services. Statistical analysis was conducted using Poisson regression models with robust variance estimator. Results: Individuals with blind/visual disability, had prior history of employment, and who received public support tended to have lower risks of non-acceptance and non-admission. Being non-White, at higher education, ever/currently married, and with physical/orthopaedic disability appeared to increase the risks of both outcomes. The adjusted relative risk of non-acceptance was 0.58 (95% confidence interval: 0.52, 0.64) if the individuals had 4 or more functional limitations as compared with those with fewer limitations. This factor was not significant for VR admission. Conclusion: Disability factors, demographic determinants, and certain miscellaneous characteristics were associated with the risks of non-acceptance and non-admission into VR. Implications for Rehabilitation Individuals with disabilities are more likely to be unemployed than the population without disabilities, and they are thus more prone to adverse health effects of unemployment. Vocational rehabilitation (VR) is a proven intervention to improve employment outcomes among individuals with disabilities. Our study indicates that the complexity of the selection process for entering VR and various factors beyond disability may prevent individuals to benefit from the VR programme. Rehabilitation programme authorities need to monitor and simplify the selection process into VR services and, together with rehabilitation practitioners, promote a selection process that pays careful attention on the factors that are related to individual risk of failure for entering VR.
The Jacket Test for assessing people with chronic stroke

Abstract Purpose: (1) To examine the intra-rater, inter-rater and test–retest reliability of Jacket Test times with 28 people with chronic stroke. (2) To determine the correlation of Jacket Test time with stroke-specific impairments. (3) To construct the optimal cutoff time for the Jacket Test that best discriminated 28 people with stroke from 30 healthy older adults. Methods: The Jacket Test completion times were measured along with the Fugl–Meyer Upper Extremity Assessment, hand grip strength, 5-times Sit-to-stand test, Berg Balance Scale and timed “up and go” test, and Community Integration Measure using the cross-sectional design. Results: The Jacket Test completion times showed excellent intra-rater, inter-rater and test–retest reliability (Intra-class Correlation Coefficient = 0.781–1.000). The unaffected-side Jacket Test times were significantly correlated with FMA-UE score, affected hand grip strength, Berg Balance Scale score, timed “up and go” test times and Community Integration Measure score. The affected-side Jacket Test times significantly correlated with affected hand grip strength. The cutoff time of 18.33s in affected side and 18.38s for unaffected side (sensitivity 96.7%; specificity 85.7–96.4%) was used to best discriminate the subjects with stroke and healthy older adults. Conclusion: The Jacket Test is a reliable and valid measure tool in clinic to evaluate the upper extremity function in people with chronic stroke. Implication for rehabilitation The Jacket Test completion times has excellent intra-rater, inter-rater and test–retest reliabilities in patients with chronic stroke. The Jacket Test completion times significantly correlated with motor functions of the upper limbs. The Jacket Test completion times of 18.33s in affected side and 18.38s for unaffected side (sensitivity 96.7%; specificity 85.7%-96.4%) was found to be the most representative for discriminating chronic stroke survivors and healthy older adults. The Jacket Test is a reliable and valid measuring tool to evaluate the upper extremity function of people with chronic stroke.
MicroRNA‐137 promoter methylation is associated with poorer overall survival in patients with squamous cell carcinoma of the head and neck

The overall 5‐year survival rate of approximately 60% for head and neck cancer patients has remained essentially unchanged over the past 30 years. MicroRNA‐137 (miR‐137) plays an essential role in cell‐cycle control at the G1/S‐phase checkpoint. However, the aberrant miR‐137 promoter methylation observed in squamous cell carcinoma of the head and neck (SCCHN) suggests a tumor‐specific molecular defect that may contribute to disease progression.
The Orthodontist's Role in 21st Century Periodontic-Prosthodontic Therapy

Often orthodontists can be of considerable assistance in periodontal and prosthodontic treatment. The orthodontists' principle periodontal objective with so-called facilitative care is to reduce or prevent excessive periodontal surgery by establishing a physiologic alveolar crestal topography. This can be done by recognizing the effect of orthodontic tooth movement (OTM) on the alveloar topography and engineering the desired contour with selective force gradients in concert with minor periodontal surgery.With this synergistic orchestration between specials the prosthetic foundation is more stable, the esthetic contour of the gingiva is improved and, most important, unnecessary removal of alveolar bone is avoided because pathologic contours due to tooth malalignment are eliminated prior to osseous surgery. Case studies are integrated herein with emerging 21st century concepts of periodontal tissue engineering
Perinatal Education Needs of Spanish-Speaking Parents in a Family Services Program in the United States

Techniques for teaching Spanish-speaking parents are of great interest in the United States and around the world. This journal issue’s “Tools for Teaching” column is written with the intent of bringing greater understanding to the teaching of Spanish-speaking parents and includes some techniques used by Teresa Visoso-Rangel in her work with this population through the Healthy Start/Healthy Families Oakland program in Pontiac, Michigan.
“Whenever I can I push myself to go to work”: a qualitative study of experiences of sickness presenteeism among workers with rheumatoid arthritis

Abstract Purpose: UK government policy emphasizes the importance of continuing to work for recovery from poor health, yet sickness presenteeism (going to work whilst ill) is commonly regarded as having negative consequences for organizations and individuals. Our study explores experiences of working after onset of rheumatoid arthritis (RA), a chronic musculoskeletal disorder characterized by high rates of work disability. Materials and methods: An exploratory qualitative study consisting of in-depth interviews and six-month follow-up with 11 men and women with RA employed at disease onset. Results: We expand upon previous models of sickness presenteeism by distinguishing between presenteeism that occurs voluntarily (wanting to work despite illness) and involuntarily (feeling pressured to work when ill). RA onset affected participants’ ability to work, yet motivation to remain working remained high. The implementation of workplace adjustments enabled participants to stay working and restore their work capacity. Conversely, managers’ misinterpretation of organizational sickness absence policies could lead to involuntary presenteeism or delayed return to work, conflicting with the notion of work as an aid to recovery. Conclusion: Workplace adjustments can facilitate voluntary sickness presenteeism. To reduce work disability and sickness absence, organizational policies should be sufficiently flexible to accommodate the needs of workers with fluctuating conditions. Implications for rehabilitation Individuals with rheumatoid arthritis (RA) are at high risk of work disability. Individuals’ motivation to remain in work following onset of RA remains high, yet sickness presenteeism (working while ill) has received largely negative attention. It is important to distinguish between voluntary and involuntary forms of sickness presenteeism. Workplace adjustments facilitate voluntary sickness presenteeism (wanting to work despite illness) and improve job retention and productivity among workers with RA. Involuntary presenteeism (feeling pressured to work while ill) may occur if organizational policies are not sufficiently flexible to accommodate the needs of workers with RA.