Miracle-dz/UniFAR-FTUs huggingface dataset:
Research assessment based on infrequent achievements: A comparison of the United States and Europe in terms of highly cited papers and Nobel Prizes

Scientific progress is driven by important, infrequent discoveries that cannot be readily identified and quantified, which makes research assessment very difficult. Bibliometric indicators of important discoveries have been formulated using an empirical approach, based on the mathematical properties of the high‐citation tail of the citation distribution. To investigate the theoretical basis of such formulations this study compares the US/European research performance ratios expressed in terms of highly cited papers and Nobel Prize‐winning discoveries. The research performance ratio in terms of papers was studied from the citation distributions in the fields of chemistry, physics, and biochemistry and molecular biology. It varied as a function of the citation level. Selecting an appropriate high citation level, the ratios in terms of highly cited papers were compared with the corresponding ratios for Nobel Prize‐winning discoveries in Chemistry, Physics, and Physiology or Medicine. Research performance ratios expressed in terms of highly cited papers and Nobel Prize‐winning discoveries are reasonably similar, and suggest that the research success of the United States is almost 3 times that of Europe. A similar conclusion was obtained using articles published in Nature and Science.
Influence of QMix irrigant on the micropush-out bond strength of biodentine and white mineral trioxide aggregate.

PURPOSE To evaluate the effect of QMix and other conventional endodontic irrigants on the micropush-out bond strength of Biodentine (BD) and white mineral trioxide aggregate (WMTA). MATERIALS AND METHODS One hundred eighty midroot dentin slices with a thickness of 1.0 mm were prepared. BD and WMTA were placed inside the lumens of the root slices (n = 90). Then the specimens of each material were divided into 6 groups (n = 15) according to irrigation solution (saline, 5.25% NaOCl, 2% CHX, 17% EDTA, or QMix) immersed in the same for 30 min. For the control group, a wet cotton pellet was placed over the specimen. After that, the micropush-out bond strength was determined using a universal testing machine, and the bond failure mode was determined using a stereomicroscope. The morphological microstructures of specimens were evaluated with scanning electron microscopy (SEM). Data were analyzed using ANOVA and Tukey's post-hoc test. RESULTS BD revealed higher bond strength than WMTA (p < 0.05). WMTA was significantly affected after exposure to 2% CHX solution. QMix irrigant did not compromise the bond strength of BD or WMTA. Most failures for BD were cohesive, while for WMTA, adhesive failures were the predominant type. A substantial change in the microstructure of BD and WMTA occurred after exposure to different irrigation solutions. CONCLUSIONS QMix did not affect the bond strength of BD or WMTA. BD showed higher resistance than WMTA to dislodgement forces from root dentin.
Expletives Deleted : Selected Writings

WITH AN INTRODUCTION BY MICHAEL MOORCOCK Angela Carter was one of the most important and influential writers of our time: a novelist of extraordinary power and a searching critic and essayist.This selection of her writing, which she made herself, covers more than a decade of her thought and ranges over a diversity of subjects giving a true measure of the wide focus of her interests: the brothers Grimm; William Burroughs; food writing, Elizbaeth David; British writing: American writing; sexuality, from Josephine Baker to the history of the corset; and appreciations of the work of Joyce and Christina Stead.
Patient-based and clinical outcomes of implant telescopic attachment-retained mandibular overdentures: a 1-year longitudinal prospective study.

PURPOSE The purpose of this study was to evaluate and compare Oral Health-Related Quality of Life (OHRQoL), denture satisfaction, and masticatory performance in edentulous patients provided with mandibular implant-supported overdentures (ISODs) retained with telescopic attachments and those of conventional complete dentures (CCDs). Peri-implant soft tissue changes were also evaluated at various intervals during a 1-year observation period. MATERIALS AND METHODS Participating patients received new CCDs and later received two mandibular interforaminal implants and had their mandibular CCDs converted into ISODs with telescopic attachments. Questionnaires were used to assess OHRQoL (Shortened Oral Health Impact Profile-14, Malaysian version) and denture satisfaction at different stages of treatment with CCDs and ISODs. Objective masticatory performance with the CCDs and ISODs was recorded with a mixing ability test. Evaluations were carried out at 3 months with the new CCDs, 3 months after mandibular ISOD provision, and 1 year after receiving the ISOD. Peri-implant parameters were additionally assessed at specific intervals during the treatment period. The data obtained were statistically analyzed and compared. RESULTS In the 17 patients who completed the protocol, significant improvements were observed in OHRQoL and patient satisfaction when CCDs were modified to ISODs, after 3 months, and at 1 year. Significantly better mixing ability with the ISOD was noted, with the highest values observed at 1 year. Statistically insignificant differences were observed for all the peri-implant parameters, except for gingival recession, for which significant changes were observed 6 months after ISOD delivery (values had stabilized by 1 year). CONCLUSION Telescopic crown attachment-retained mandibular ISODs improved OHRQoL, dental prosthesis satisfaction, and masticatory performance compared to CCDs. Peri-implant soft tissue response and implant stability were found to be favorable after 1 year.
Prognostic Factors for Risk Stratification of Patients with Recurrent or Metastatic Pancreatic Adenocarcinoma Who Were Treated with Gemcitabine-Based Chemotherapy

Purpose The aim of this study was to verify prognostic factors including sarcopenia in patients with recurrent or metastatic pancreatic cancer receiving gemcitabine-based chemotherapy. Materials and Methods Medical records and computed tomography scan of consecutive patients treated with palliative gemcitabine-based chemotherapy from 2008 to 2014 were reviewed. The lumbar skeletal muscle index at third lumbar spine level was computed, and together with clinicolaboratory factors, univariate and multivariable analyses for overall survival (OS) were performed. Results A total of 88 patients were found. Median age was 65 years, and male patients were predominant (67.0%). Most patients had initially metastatic disease (72.7%), and gemcitabine monotherapy was administered in 29 patients (33.0%) while gemcitabine plus erlotinib was administered in 59 patients (67.0%). Seventy-six patients (86.3%) had sarcopenia. With a median follow-up period of 44.3 months (range, 0.6 to 44.3 months), median OS was 5.35 months (95% confidence interval [CI], 4.11 to 6.59). In univariate and multivariable analysis, high carcinoembryonic antigen level (hazard ratio [HR], 4.18; 95% CI, 1.95 to 8.97; p < 0.001), initially metastatic disease (HR, 3.37; 95% CI, 1.55 to 7.32; p=0.002), sarcopenia (HR, 2.97; 95% CI, 1.20 to 7.36; p=0.019), neutrophilia (HR, 2.94; 95% CI, 1.27 to 6.79; p=0.012), and high lactate dehydrogenase level (HR, 1.96; 95% CI, 1.07 to 3.58; p=0.029) were identified as independent prognostic factors for OS. Conclusion Five independent prognostic factors in patients with recurrent or metastatic pancreatic cancer who received gemcitabine-based chemotherapy were identified. These findings may be helpful in prediction of prognosis in clinical practice and can be used as a stratification factor for clinical trials.
Automatic Change Detection in Synthetic Aperture Radar Images Based on PCANet

This letter presents a novel change detection method for multitemporal synthetic aperture radar images based on PCANet. This method exploits representative neighborhood features from each pixel using PCA filters as convolutional filters. Thus, the proposed method is more robust to the speckle noise and can generate change maps with less noise spots. Given two multitemporal images, Gabor wavelets and fuzzy c-means are utilized to select interested pixels that have high probability of being changed or unchanged. Then, new image patches centered at interested pixels are generated and a PCANet model is trained using these patches. Finally, pixels in the multitemporal images are classified by the trained PCANet model. The PCANet classification result and the preclassification result are combined to form the final change map. The experimental results obtained on three real SAR image data sets confirm the effectiveness of the proposed method.
A bright green perspective on sustainable choices

We present a qualitative study of 35 United States households whose occupants have made significant accommodations to their homes and behaviors in order to be more environmentally responsible. Our goal is to inform the design of future sustainable technologies through an exploration of existing "green" lifestyles. We describe the motivations, practices, and experiences of the participants. The participants had diverse motivations ranging from caring for the Earth to frugal minimalism, and most participants also evidenced a desire to be unique. Most participants actively and consciously managed their homes and their daily practices to optimize their environmental responsibility. Their efforts to be environmentally responsible typically required significant dedication of time, attention, and other resources. As this level of commitment and desire to be unique may not generalize readily to the broader population, we discuss the importance of interactive technologies that influence surrounding infrastructure and circumstances in order to facilitate environmental responsibility.
Validity of Urine Specific Gravity When Compared With Plasma Osmolality as a Measure of Hydration Status in Male and Female NCAA Collegiate Athletes

Abstract Sommerfield, LM, McAnulty, SR, McBride, JM, Zwetsloot, JJ, Austin, MD, Mehlhorn, JD, Calhoun, MC, Young, JO, Haines, TL, and Utter, AC. Validity of urine specific gravity when compared with plasma osmolality as a measure of hydration status in male and female NCAA collegiate athletes. J Strength Cond Res 30(8): 2219–2225, 2016—The purpose of this study was to evaluate the response of urine specific gravity (Usg) and urine osmolality (Uosm) when compared with plasma osmolality (Posm) from euhydration to 3% dehydration and then a 2-hour rehydration period in male and female collegiate athletes. Fifty-six National Collegiate Athletic Association (NCAA) wrestlers (mean ± SEM); height 1.75 ± 0.01 m, age 19.3 ± 0.2 years, and body mass (BM) 78.1 ± 1.8 kg and 26 NCAA women's soccer athletes; height 1.64 ± 0.01 m, age 19.8 ± 0.3 years, and BM 62.2 ± 1.2 kg were evaluated. Hydration status was obtained by measuring changes in Posm, Uosm, Usg, and BM. Male and female subjects dehydrated to achieve an average BM loss of 2.9 ± 0.09% and 1.9 ± 0.03%, respectively. Using the medical diagnostic decision model, the sensitivity of Usg was high in both the hydrated and dehydrated state for males (92%) and females (80%). However, the specificity of Usg was low in both the hydrated and dehydrated states for males (10 and 6%, respectively) and females (29 and 40%, respectively). No significant correlations were found between Usg and Posm during either the hydrated or dehydrated state for males or females. Based on these results, the use of Usg as a field measure of hydration status in male and female collegiate athletes should be used with caution. Considering that athletes deal with hydration status on a regular basis, the reported low specificity of Usg suggests that athletes could be incorrectly classified leading to the unnecessary loss of competition.
Low‐fluence Q‐switched Nd: YAG 1064‐nm laser and intense pulsed light for the treatment of melasma

Low‐fluence Q‐switched Nd:YAG 1064 nm laser (LFQS) and intense pulsed light (IPL) have been shown to be effective in the treatment of melasma. LFQS can target deeper pigment, while IPL can target a wide range of cutaneous structures. However, there is limited information on efficacy and side‐effects of the combined treatment.
Overweight and obesity in infants and pre‐school children in the European Union: a review of existing data

The objective of this study was to synthesize available information on prevalence and time trends of overweight and obesity in pre‐school children in the European Union. Retrieval and analysis or re‐analysis of existing data were carried out. Data sources include WHO databases, Medline and Google, contact with authors of published and unpublished documents. Data were analysed using the International Obesity Task Force reference and cut‐offs, and the WHO standard. Data were available from 18/27 countries. Comparisons were problematic because of different definitions and methods of data collection and analysis. The reported prevalence of overweight plus obesity at 4 years ranges from 11.8% in Romania (2004) to 32.3% in Spain (1998–2000). Countries in the Mediterranean region and the British islands report higher rates than those in middle, northern and eastern Europe. Rates are generally higher in girls than in boys. With the possible exception of England, there was no obvious trend towards increasing prevalence in the past 20–30 years in the five countries with data. The use of the WHO standard with cut‐offs at 1, 2 and 3 standard deviations yields lower rates and removes gender differences. Data on overweight and obesity in pre‐school children are scarce; their interpretation is difficult. Standard methods of surveillance, and research and policies on prevention and treatment, are urgently needed.
Post-LASIK Epithelial Dendritic Defect Associated With Alternaria

Purpose: To report a case of a dendritic epithelial defect with interface inflammation associated with Alternaria sp. after laser in situ keratomileusis (LASIK) surgery. Methods: A case report of a 46-year-old woman who presented with a dendritic epithelial defect and interface inflammation after LASIK surgery. Results: After an apparent post-LASIK herpes simplex keratitis with related interface inflammation failed to respond to medical therapy, cornea culture results were positive for Alternaria fungal sp. 2 weeks and 6 days after presentation. Viral cultures and polymerase chain reaction were negative for herpes simplex virus. Six months after penetrating keratoplasty (and 1 year after LASIK), the patient underwent a cataract extraction OD. Best-corrected visual acuity 18 months after the original LASIK procedure was 20/25 OD. Conclusions: Alternaria keratitis may present with a dendritic epithelial defect with interface inflammation mimicking herpes simplex virus.
La part respective des facteurs hydroclimatiques et anthropiques dans l'évolution récente (1956-2000) de la bande active du Haut Guil, Queyras, Alpes françaises du Sud

L'objectif de l'etude est de quantifier la variabilite spatiale 2D de la bande active du Haut Guil (23,3 km) et de considerer les fluctuations hydroclimatiques et l'artificialisation du fond de vallee comme les deux principaux facteurs potentiellement responsables des changements. L'analyse s'appuie sur quatre-vingt sites selectionnes tous les 250-300 m sur quatre series de photographies aeriennes (1956, 1957, 1999 et 2000). Les variables prises en compte sont la surface et la largeur de la bande active, l'indice de tressage et les infrastructures presentes dans le fond de vallee. Les resultats montrent que la variabilite spatiale de la bande active du Haut Guil est tres forte depuis la seconde partie du XXe siecle. La bande active s'elargit et le tressage se renforce apres le passage des evenements hydroclimatiques haute magnitude-basse frequence de juin 1957 (> Q100) et juin 2000 (Q30). La bande active se contracte et le tressage diminue entre 1957 et 1999 en raison de l'absence d' evenements hydroclimatiques veritablement morphogenes et de la mise en place, dans le fond de vallee, des remblais supportant la route principale Château-Queyras/La Roche Ecroulee. Ce modele d'evolution est original par rapport a certains modeles decrits dans la litterature. Le modele d'evolution des bassins de moyenne altitude ne parait pas etre transposable a celui des hauts bassins montagnards, dans lesquels le calibrage des bandes actives reste beaucoup plus dependant de la variabilite hydroclimatique, en raison de la vigueur des aleas et des difficultes a pouvoir veritablement maitriser leurs effets hydrogeomorphologiques sur tous les segments des cours d'eau.
Barium selenate injections in cattle: effects on selenium concentrations in plasma and liver and residues at site of injection

Twenty Angus cross heifers were fed a complete diet which contained 0.07 mg selenium/kg dry matter. Thirteen were injected subcutaneously with barium selenate at a dose rate of approximately 1 mg selenium/kg bodyweight and seven remained untreated. All the heifers were slaughtered during the following 121 days, the last of the treated group 119 days after injection. Glutathione peroxidase activity in blood increased within four weeks of administration and remained high thereafter. The selenium dependent glutathione peroxidase activity did not increase in liver kidney or muscle. The concentrations of selenium in the blood, liver and muscle were increased significantly from 30 days until 119 days. Between 76 and 99 per cent of the selenium injected remained at the site of injection.
Increased risk of lymphoma among inflammatory bowel disease patients treated with azathioprine and 6-mercaptopurine

Background: Inflammatory bowel disease (IBD) is commonly treated with immunomodulators such as azathioprine and 6-mercaptopurine (6-MP). Studies examining lymphoma risk in IBD patients treated with these medications have been underpowered and have yielded conflicting conclusions. Aims: The purpose of this meta-analysis was to provide a more precise estimate of the relative risk of lymphoma among IBD patients treated with azathioprine or 6-MP. Methods: Studies were included if they were English language, full article, cohort studies specifically designed to evaluate cancer as an adverse outcome of treatment with azathioprine or 6-MP. Pooled standardised incidence ratios were calculated to estimate the relative risk of lymphoma associated with therapy. Heterogeneity was assessed using Poisson regression. Sensitivity analyses examined the influence of individual studies on risk estimate and heterogeneity statistics. Results: Six studies were identified that met our inclusion criteria. When the data were combined across all studies, the pooled relative risk was 4.18 (95% confidence interval 2.07–7.51; 11 observed cases, 2.63 expected). Sensitivity analysis showed that exclusion of any one study had a relatively small effect on the pooled relative risk estimate (range 3.49–5.21) but excluding either the study with the highest or lowest estimated relative risk eliminated the statistically significant heterogeneity. Conclusions: Our data suggest an approximate fourfold increased risk of lymphoma in IBD patients treated with azathioprine/6-MP. The increased risk of lymphoma could be a result of the medications, the severity of the underlying disease, or a combination of the two.
Testing lupus anticoagulants in a real-life scenario - a retrospective cohort study

Introduction Lupus anticoagulant (LAC) testing is challenging. Most data are derived from a well-controlled study environment with potential alterations to daily routines. The aim of this retrospective cohort study was to assess the capacity of various LAC screening tests and derived mixing tests to predict a positive result in subsequent confirmation tests in a large cohort of patients. Materials and methods In 5832 individuals, we retrospectively evaluated the accuracy of the aPTT-A, aPTT-LAscreen, aPTT-FS and dRVVTscreen and of their derived mixing tests in detecting a positive confirmation test result within the same blood specimen. The group differences, degree of correlation and the predictive accuracy of LAC coagulation tests were analysed using the Mann-Whitney U test, the Spearman-rank-correlation and by area under the receiver operating characteristic curve (ROC-AUC) analysis. ROC-AUCs were compared with the Venkatraman´s permutation test. Results The pre-test probability of patients with clinically suspected LAC was 36% in patients without factor deficiency or anticoagulation therapy. The aPTT-LAscreen showed the best diagnostic accuracy with a ROC-AUC of 0.84 (95% CI: 0.82 – 0.86). No clear advantage of the dRVVT-derived mixing test was detectable when compared to the dRVVTscreen (P = 0.829). Usage of the index of circulating anticoagulant (ICA) did not improve the diagnostic power of respective mixing tests. Conclusions Among the parameters evaluated, aPTT-LAscreen and derived mixing test parameters were the most accurate tests. In our study cohort, neither other mixing test nor the ICA presented any further advantage in LAC diagnostics.
Augmented HIV-Specific Interferon-Gamma Responses, But Impaired Lymphoproliferation During Interruption of Antiretroviral Treatment Initiated in Primary HIV Infection

Background:Antiretroviral therapy (ART) introduced during primary HIV infection followed by treatment interruption (TI) is postulated to enhance virologic control through induction of HIV-specific CD4+ T cells, which foster virus-specific CD8+ T cells that suppress virus replication. This hypothesis was evaluated in 21 subjects enrolled in AIDS Clinical Trials Group 709, a substudy of AIDS Clinical Trials Group 371, which prospectively evaluated subjects who received ≥1 year of ART initiated in acute or recent HIV infection followed by TI. Methods:Lymphoproliferation was assessed by [methyl-3H] thymidine incorporation and HIV-specific CD8+ T-cell interferon-gamma responses by enzyme-linked immunospot-forming assays. Virologic success was defined as sustained viral load <5000 copies per milliliter for 24 weeks after TI. Results:HIV-specific lymphoproliferative responses were detected at least once in 5 (24%) of 21 subjects, were generally transient, and were unrelated to HIV-specific interferon-gamma responses (P > 0.4). HIV-specific CD8+ interferon-gamma responses increased after 48 weeks of ART (P = 0.03), but failed to predict virologic success (P = 0.18). Compared with seronegative subjects, lymphoproliferation to Candida, cytomegalovirus, and alloantigens was similar in HIV-infected subjects during ART, but lower during TI (P ≤ 0.04). Conclusions:HIV-specific CD8+ T-cell interferon-gamma responses expand during ART following primary HIV infection, but are not related to HIV-specific lymphoproliferative responses nor virologic success. Impaired non-HIV antigen-specific lymphoproliferation associated with TI suggests this strategy could be deleterious.