Miracle-dz/UniFAR-FTUs huggingface dataset:
THE PREVALENCE OF MYOPIA VIS-À-VIS THE TYPE OF DIET IN YOUNG ADULTS IN INDIA

Nurture’ and ‘nature’ interact to produce myopia. This study probed the relation of myopia with the type of diet i.e. vegetarian or non-vegetarian, in young adults in India. One hundred forty eight young adults were tested for myopia and the odds of the vegetarian and non-vegetarian participants being affected were calculated. These were subjected to test of statistical significance. We report a trend of vegetarian participants having a higher prevalence of myopia, though not reaching the level of statistical significance. Available evidence on the role of various components of diet has been compiled and
Nanozeolite‐driven approach for enrichment of secretory proteins in human hepatocellular carcinoma cells

Given the importance of secreted proteins as a source for early detection and diagnosis of disease, secreted proteins have been arousing considerable attention. However, the analysis of secreted proteins represents a challenge for current proteomic techniques. One of the difficulties in secretomic study is to concentrate proteins from large volume of growth media, particularly, the low abundant and low molecular weight proteins (molecular weight <30 kDa). Herein, we describe a novel strategy for harvesting secretory proteins. In this approach, proteins secreted from the human hepatocellular carcinoma cell line were enriched by zeolite LTL nanocrystals, followed by 1‐D SDS‐PAGE for protein fractionation and then by LC‐ESI‐MS/MS for protein identification. In total, 1474 unique proteins were confidently identified, including 505 low molecular weight proteins, and covered a broad range of pI and molecular weight. Furthermore, this study not only offered an efficient and powerful method for the enrichment of secretory proteins but also allowed in‐depth study of secretome of hepatocellular carcinoma cells. The reported work is expected to represent one of the most comprehensive secretomic analyses so far.
ANALISIS PENGARUH OPINI AUDIT, UKURAN KANTOR AKUNTAN PUBLIK (KAP), UKURAN PERUSAHAAN KLIEN, DAN KEPEMILIKAN MANAJERIAL TERHADAP AUDITOR SWITCHING (Studi Empiris Pada Perusahaan Manufaktur Subsektor Makanan dan Minuman, Farmasi, Rokok yang Terdaftar di Bu

Penelitian ini bertujuan untuk menguji faktor–faktor yang mempengaruhi auditor switching. Faktor-faktor tersebut adalah opini audit, ukuran KAP, ukuran perusahaan klien dan kepemilikan manajerial. Penelitian sebelumnya terdiri dari : (1) Andri Prastiwi (2009), (2) Ni Wayan Ari Juliantari (2013), (3) I Made Agus Setiawan (2014). Populasi pada penelitian ini adalah perusahaan manufaktur subsektor makanan dan minuman, farmasi dan rokok yang terdaftar di Bursa Efek Indonesia tahun 2009-2013. Total sampel dalam penelitian ini adalah 11 perusahaan menggunakan metode purposive sampling . Analisis data menggunakan regresi logistik dengan bantuan SPSS 19. Hasil penelitian menunjukkan bahwa ukuran KAP berpengaruh secara signifikan terhadap auditor switching . Sedangkan, opini audit, ukuran perusahaan klien dan kepemilikan manajerial tidak berpengaruh secara siginifikan terhadap auditor switching .
Cannabinoids disrupt hippocampal sharp wave‐ripples via inhibition of glutamate release

Cannabis consumption results in impaired learning. The proper synchronization of neuronal activity in the mammalian hippocampus gives rise to network rhythms that are implicated in memory formation. Here, we have studied the impact of cannabinoids on hippocampal sharp waves and associated ripple oscillations using field‐ and whole‐cell voltage‐clamp recordings. We demonstrate that the activation of cannabinoid receptor 1 suppresses sharp wave‐ripples (SWRs) in mice in vivo and in vitro. This suppression was paralleled by a selective reduction of SWR‐associated inward but not outward charge transfer, demonstrating an impairment of excitation due to cannabinoid exposure. Adenosine, a presynaptic modulator of glutamate release, mimicked and occluded the observed consequences of cannabinoids on SWRs. We conclude that inhibition of glutamatergic feed‐forward excitation can explain cannabinoid‐mediated disruption of SWRs and may account for cannabinoid‐induced impairment of hippocampus‐dependent memory. © 2011 Wiley Periodicals, Inc.
Positive control for cytotoxicity evaluation of dental vinyl polysiloxane impression materials using sodium lauryl sulfate

Abstract Objectives. Vinyl polysiloxane (VPS) is elastomeric dental impression material which, despite having very few reports of adverse reactions, has shown high levels of cytotoxicity that is difficult to be interpreted without referencing to the positive control material. Therefore, in this study, positive control VPS was developed using sodium lauryl sulfate (SLS) for the reference of cytotoxicity test. Materials and methods. The positive control VPS with SLS was formed with a different proportion of SLS (0, 1, 2, 4, 8 and 16 wt%) added to the base. The cytotoxicity test was then carried out using the extractions or dilutions of the extractions from each of the test samples using murine fibroblast cells (L929). Results. The final product of positive control VPS behaved similar to commercially available VPS; being initially liquid-like and then becoming rubber-like. Ion chromatography showed that the level of SLS released from the product increased as the proportion of added SLS increased, consequently resulting in an increased level of cytotoxicity. Also, the commercially available VPS was less cytotoxic than the positive control VPS with more or equal to 2 wt% of SLS. However, even the VPS with the highest SLS (16 wt%) did not cause oral mucosa irritation during the animal study. Conclusions. The positive control VPS was successfully produced using SLS, which will be useful in terms of providing references during in vitro cytotoxicity testing.
HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone‐fold proteins

Chromatin remodelling complexes containing the nucleosome‐dependent ATPase ISWI were first isolated from Drosophila embryos (NURF, CHRAC and ACF). ISWI was the only common component reported in these complexes. Our purification of human CHRAC (HuCHRAC) shows that ISWI chromatin remodelling complexes can have a conserved subunit composition in completely different cell types, suggesting a conserved function of ISWI. We show that the human homologues of two novel putative histone‐fold proteins in Drosophila CHRAC are present in HuCHRAC. The two human histone‐fold proteins form a stable complex that binds naked DNA but not nucleosomes. HuCHRAC also contains human ACF1 (hACF1), the homologue of Acf1, a subunit of Drosophila ACF. The N‐terminus of mouse ACF1 was reported as a heterochromatin‐targeting domain. hACF1 is a member of a family of proteins with a related domain structure that all may target heterochromatin. We discuss a possible function for HuCHRAC in heterochromatin dynamics. HuCHRAC does not contain topoisomerase II, which was reported earlier as a subunit of Drosophila CHRAC.
FEEDING THE SOW : COMPARISON OF GESTATIONAL AND LACTATION PROGRAMS

There are a number of reasons that sow nutritional performance during lactation is of great interest to producers. In a series of extension articles, Flowers (2002a,b) indicated that, when troubleshooting reproductive problems in sows, a key event to investigate carefully is feed intake during previous lactation. Besides the reproductive performance of the sow, piglet performance is also intrinsically associated with the nutritional status and, as a result, milk production, of its dam (Noblet and Etienne, 1989). Piglets that are weaned greater than 3.5 kg have a 3x more chance of surviving to market and an 8.5x chance of not being lightweight at 10 weeks of age (Larriestra et al. 2005).
Mitochondrial genome of the Shorthead catfish (Pelteobagrus eupogon)

The complete mitochondrial genome of Shorthead catfish (Pelteobagrus eupogon) was obtained by DNA sequencing based on the PCR fragments. The entire genome was 16,562 bp in length, with a gene content of 13 protein-coding, 2 ribosomal RNA, and 22 transfer RNA genes, and order identical to that observed in most other vertebrates. Those genes are arranged compactly with no introns and few intergenic nucleotides. Molecular data here presented provide a useful toll for evolutionary as well as population genetic studied.
Depression, Anxiety, Hopelessness, and Social Support Levels of the Parents of Children With Cancer

When a child is diagnosed with cancer, family members are affected both socially and psychologically. This study was conducted to determine the depression, anxiety (state and trait), hopelessness, and perceived social support levels of 94 parents of children with cancer followed up at a university hospital. Data were collected using a questionnaire form and included descriptive characteristics, Beck Depression Inventory, Multidimensional Scale of Perceived Social Support, State—Trait Anxiety Inventory, and The Hopelessness Scale. A positive relationship was found between depression and hopelessness scores and between state and trait anxiety scores for both mothers and fathers. Also, a negative relationship was found between social support and depression scores and between hopelessness and social support scores. Apart from fathers, a positive relationship between depression and trait anxiety scores and a negative relationship between state anxiety and hopelessness scores were found in mothers. Based on these results, it seems that it would be highly beneficial to provide psychological and social support and social support groups to help parents cope with these problems.
Ownership Structure and Corporate Performance of Multinational Banks: Evidence from Nigeria

This study investigated whether a significant relationship exists between ownership concentration and corporate performance of Nigerian multinational banks. The corporate annual reports for the periods 2010-2014 were utilised as the main source of secondary data. In testing the research hypotheses, the study adopted the use of panel least square regression method to analyse the data collected from annual reports of the Nigerian multinational banks. Also, the study made use of correlational research design for testing the expected relationship between the variables. Findings revealed a significant negative relationship between ownership concentration and corporate performance of Nigerian multinational banks. In addition, an insignificant positive impact of foreign ownership on corporate performance exists. We also found a significant negative impact of domestic ownership on corporate performance. The study recommends that Nigerian multinational banks should reduce ownership concentration and domestic ownership in order to increase the level of corporate performance. In addition, foreign ownership should be encouraged as a result of its technical expertise and financial support that improve corporate performance.
A decision support system for demand and capacity modelling of an accident and emergency department

ABSTRACT Accident and emergency (A&E) departments in England have been struggling against severe capacity constraints. In addition, A&E demands have been increasing year on year. In this study, our aim was to develop a decision support system combining discrete event simulation and comparative forecasting techniques for the better management of the Princess Alexandra Hospital in England. We used the national hospital episodes statistics data-set including period April, 2009 – January, 2013. Two demand conditions are considered: the expected demand condition is based on A&E demands estimated by comparing forecasting methods, and the unexpected demand is based on the closure of a nearby A&E department due to budgeting constraints. We developed a discrete event simulation model to measure a number of key performance metrics. This paper presents a crucial study which will enable service managers and directors of hospitals to foresee their activities in future and form a strategic plan well in advance.
Insulin resistance in migraineurs: Results from a case-control study

Objectives: Several studies have suggested an association between migraine and insulin resistance (IR) without adequately addressing the issue according to migraine type. We assessed IR in subjects with migraine with aura (MwA) and migraine without aura (MwoA) to estimate the consistency of the possible association. Methods: In a case-control study we included case subjects with MwA and MwoA, who were consecutively selected from those referred to our Regional Headache Center from September 2011 to February 2013, and age-matched control subjects selected using general practitioners’ databases. IR was calculated by means of the homeostatic model assessment of IR (HOMA-IR), β-cell function (HOMA-B), and the quantitative insulin sensitivity check index (QUICKI) measuring glucose and insulin values in a blood sample collected in the morning after overnight fasting. Data regarding anthropometric measures, comorbidity risk factors, and migraine characteristics were also recorded. Results: We recruited 50 case subjects with MwA (38 women) and 50 with MwoA (40 women) and 50 control subjects (40 women). Proportions of arterial hypertension, cigarette smoking, hypercholesterolemia, use of oral contraceptives, and mean values of the body mass index (BMI) were similar in the three groups. We found significantly different glucose values among and within groups considering case subjects with MwA and MwoA and control subjects (4.9 ± 0.6 vs 4.7 ± 0.5 vs 4.6 ± 0.5 mmol/l; p = 0.018) in the absence of any difference in insulin (53.1 ± 24.0 vs 56.7 ± 34.4 vs 53.8 ± 24.4 pmol/l; p = 0.811), HOMA-IR (1.6 ± 0.8 vs 1.7 ± 1.0 vs 1.6 ± 0.7; p = 0.765), HOMA-B (121.4 ± 71.1 vs 149.2 ± 93.8 vs 162.8 ± 109.7; p = 0.107), and QUICKI (0.36 ± 0.03 vs 0.37 ± 0.03 vs 0.37 ± 0.03; p = 0.877) values. The logistic regression model showed increased odds of MwA in subjects exposed to the highest tertile of glucose values. This association was confirmed in the adjusted model, in which case subjects with MwA were compared with those with MwoA but not with control subjects. Conclusions: In contrast to what has been shown by the majority of the available studies, the results of our study do not support the association of migraine with IR. As our study was not population-based and several patients had low disease activity, these findings need further confirmation.
Predicting Participation in Ultrasound Hip Screening From Message Framing

The use of ultrasound (US) screening for developmental dysplasia of the hip (DDH) is an innovation in preventive child health care in the Netherlands. What is not known is whether parents will accept this screening method and will actually participate in it. It is widely known that health behaviors can be influenced by the framing of information. The objective of this study was to examine the influence of a gain- versus loss-framed brochure on parental participation in US screening for DDH. In total, 4150 parents of infants born between August 2007 and December 2008 received either a gain-framed or a loss-framed brochure. Parents could participate in the screening when their infant was 3 months old. The participation rate in the US screening was 74.3%. In contrast to the predictions of prospect theory, the results indicated that parents who had received the gain-framed message were more likely to participate in the screening compared to parents who had received the loss-framed message. This effect may be explained by the low risk perception of parents and by the possibility that the screening was perceived as a health-affirming behavior rather than an illness-detecting behavior. To increase participation rates, it is recommended that parents be informed about the positive aspects of partaking in screening for DDH.
Variant TREM2 as risk factor for Alzheimer's disease.

Current knowledge about the pathogenic mechanism of Alzheimer's disease is based mainly on rare, high-penetrance variants in genes encoding amyloid precursor protein, presenilin 1, and presenilin 2, which result in familial early-onset Alzheimer's disease. However, Alzheimer's disease is predominantly a sporadic late-onset disease with exponentially increasing prevalence starting at the age of 65 years. Genomewide association studies have recently identified several risk variants for late-onset Alzheimer's disease, but aside from the well-known e4 allele of apolipoprotein E, these variants are generally associated with very low risk; in addition, such variants are noncoding and more challenging to link to molecular function.
The Flash Crash: High-Frequency Trading in an Electronic Market

We study intraday market intermediation in an electronic market before and during a period of large and temporary selling pressure. On May 6, 2010, U.S. financial markets experienced a systemic intraday event, known as the Flash Crash, when a large automated sell program was rapidly executed in the E-mini S&P 500 stock index futures market. Using audit trail transaction-level data for the E-mini on May 6 and the previous three days, we find that the trading pattern of the most active non-designated intraday intermediaries (classified as High Frequency Traders) did not change when prices fell during the Flash Crash.
Dynamical properties of a hole in a Heisenberg antiferromagnet.

The {ital t}-{ital J} model in the large-{ital t}/{ital J} and low-doping limit is approximated by an effective Hamiltonian that treats spin degrees of freedom within the linear-spin-wave approximation and the hole-hopping term with a hole-spin interaction vertex that is linear in the spin-wave operators. The Dyson's equation for the single-hole Green's function is solved numerically on finite- but sufficiently large-size square lattices. Our calculation is based on an approximate equation for the hole motion that has been obtained using a self-consistent perturbation approach where crossing diagrams are neglected. We have studied the contribution of vertex corrections and found that the leading two-loop crossing diagram is exactly zero. Thus, the leading nonzero contribution to the proper self-energy from crossing diagrams is a three-loop correction. In two dimensions, it is possible to solve Dyson's equation numerically including these three-loop corrections. The results demonstrate that the contribution of such vertex corrections is indeed small. Our solution for the hole spectral function, obtained by neglecting such small contributions from vertex corrections, shows that most features describing the hole motion are in close agreement with the results of the exact diagonalization on the 4{sup 2} lattice in the region of {ital J}/{ital t}{le}0.2. Themore » results obtained on sufficiently large-size lattices suggest that certain important features of the spectral function remain while others change due to finite-size effects. In particular, we find well-defined peaks above the lowest-energy peak that survive in the thermodynamic limit. We analyze these higher-energy peaks of the spectral functions and find that they can be understood as string'' excitations, which are created by the hole moving in a nearly linear potential. « less
Vitamin D – binding protein and pancreatic cancer : a nested case-control study 1 – 5

Background: Vitamin D–binding protein (DBP) is the primary carrier of 25-hydroxyvitamin D [25(OH)D] in the circulation. One prospective study in male smokers found a protective association between DBP and pancreatic cancer, particularly among men with higher 25(OH)D concentrations. Objective: The objective was to examine the association between DBP and pancreatic cancer risk in an American population. Design: We conducted a nested case-control study in the Prostate, Lung, Colorectal, and Ovarian Cancer screening trial cohort of men and women aged 55–74 y at baseline. Between 1993 and 2010, 295 incident pancreatic adenocarcinoma cases were reported (follow-up to 15.1 y). Two controls (n = 590) were matched to each case by age, race, sex, and month of blood draw. We calculated smokingand diabetes-adjusted ORs and 95% CIs with the use of conditional logistic regression. Results: DBP concentration was not significantly associated with pancreatic cancer overall [highest ($7149.4 nmol/L) vs. lowest (,3670.4 nmol/L) quintile; OR: 1.75; 95% CI: 0.91, 3.37; P-trend = 0.25]. For serum 25(OH)D compared with the referent (50 to ,75 nmol/L), individuals in the highest group had a significantly higher risk ($100 nmol/L; OR: 3.23; 95% CI: 1.24, 8.44), whereas those in the lowest group had no significant association (,25 nmol/L; OR: 2.50; 95% CI: 0.92, 6.81). Further adjustment for DBP did not alter this association. Conclusion: Our results do not support the hypothesis that serum DBP or 25(OH)D plays a protective role in pancreatic cancer. This trial was registered at clinicaltrials.gov as NCT00339495. Am J Clin Nutr doi: 10.3945/ajcn.114. 096016.
The Effect of Business Intelligence and Intellectuals Capital of Company Value Moderated by Management of Profit Riil

The research purposes to analyze the influence of business intelligence and intellectual capital on firm value, and also the role of real earnings management as moderated variable. This research used annual report as secondary data. The number of beginning samples were 420 manufacturing firms. The final samples were 284 samples had a positive cash flow, because this study did not use samples with negative cash flow. This research uses moderated multiple regression and treat real earnings management as pure moderated variables. The results showed that business intelligence and intellectual capital had positive effects on firm value. Moreover, real earnings management significantly moderated the relationship between business intelligence, intellectual capital and firm value. The implication of the research showed that the company must give attention to business intelligence, intellectual capital and real earnings management. All independent variables can explain 86% of the variation in firms value.
Meeting the training needs for knowledge and content management Specialists: Case study of Southern African Universities

Information professionals have been in the information provision business for long period of time. Along the way, approaches to information provision have been dynamic owing to the advent of the knowledge era. As need to offer information and knowledge services via variety of skills intensifies, institutions imparting information provision skills must respond to the demand. However, the extent to which such demands for contemporary skills in information provision have been satisfied still remains unknown, more so within the Southern African Region. In view of the above, this study investigated changes in curricular for LIS departments towards imparting contemporary skills for effective knowledge and content management in Southern African Universities. The study used a qualitative approach for data collection and analysis. The study revealed, among other things, the status in terms of courses offered by the Universities with regard to imparting contemporary information and knowledge provision and management skills, necessary for knowledge and content management work in organisations.