Miracle-dz/UniFAR-FTUs huggingface dataset:
Review of Prognostic Indicators Head and Neck Mucosal Malignant Melanoma : Clinicopathologic Correlation With Contemporary

Unlike their cutaneous counterparts, head and neck mucosal malignant melanomas (HNMM) behave much more aggressively and their prognostic markers have not been fully elucidated. Therefore, the aim of this study was to review the clinicopathologic features of a contemporary series of primary HNMM, retrieved from archival material of 2 large medical centers, and to explore the association, if any, between these variables, the clinical features, and outcomes. The clinicopathologic, radiographic, and follow-up information as well as the dominant histologic pattern, mitotic rate, presence/absence of pigmentation, necrosis, ulceration, vascular invasion, and host-associated lymphocytic response were retrieved and recorded. Twenty cases were identified including 1 melanoma in situ. Eight-five percent of tumors arose in the sinonasal tract and 3 (15%) in the oral cavity. After a median follow-up of 25 months, all patients with invasive melanoma developed recurrence and/or metastasis. Local recurrences occurred in 82% of the patients after a median of 12 months, and distant metastasis occurred in 71% of the patients after a median of 13 months. Of those with adequate follow-up, 82% died with disease, and the remaining 3 had recurrent or metastatic disease. Fourth-seven percent of tumors were pigmented, 89% showed at least focal necrosis, and 93% demonstrated ulceration. Sixth-eight percent showed vascular invasion and 63% had a brisk host lymphocytic response. Mitotic rates ranged from 2 to 60/10 high-power fields. The absence of an invasive component might be associated with a better prognosis but other clinical and pathological features that predict outcome, and/or could influence therapy, remain to be determined in HNMM.
Intercalation of urea into kaolinite for preparation of controlled release fertilizer

Urea was intercalated between layers of kaolinite by dry grinding technique to be used for preparation of controlled release fertilizer. X-ray powder diffraction (XRPD)patterns confirmed the intercalation of urea into kaolinite by the significant expansion of the basal spacing of kaolinite layers from 0.710 to 1.090 nm. Fourier transform infrared spectroscopy (FT-IR) also confirmed the hydrogen bonding between urea and kaolinite. Based on CHNS elemental analysis, 20 wt. % urea was intercalated between kaolinite layers. The urea-inter-calated kaolinite was mixed with hydroxypropyl methylcellulose (HPMC) binder and was granulated to prepare the nitrogen-based controlled release fertilizer. To study the nitrogen release behavior of granules, ultraviolet/visible (UV-Vis) spectroscopy was used through the diacetyl monoxime (DAM) colorimetric method. The result of UV-Vis spectroscopy showed that intercalation of urea into kaolinite decreased the nitrogen release from 25.50 to 13.66% after 24 h and from 98.15 to 70.01% after 30 days of incubation in water. According to the results, the prepared controlled release fertilizer (CRF) behaved according to the standard for CRFs.
No Occasion for Pleasure: The Self-Worth Contingency of a Setback and Coping With Humor

Whether or not one uses humor to cope with a setback may depend on the idiosyncratic relation of the setback to feeling of self-worth. All people pursue the higher order goal of self-validation, but people differ in what domains of life their self-worth is contingent upon and to what extent. In this article based on an incongruity theory of humor we argue that the use of humor in coping with a highly self-worth-contingent setback may be impeded by two cognitive-motivational processes: goal-driven activation and goal shielding. From the outlined theory we derived the hypothesis that the more a domain is contingent upon self-worth, the less likely a person will be to use humor to deal with a setback in that domain. We tested this hypothesis in two studies employing two forms of self-report, i.e., ratings of reaction likelihood to setbacks described at an abstract domain level (Study 1), and ranking of reaction likelihood to concrete setbacks from different domains (Study 2). The hypothesis was affirmed in different domains of self-worth contingency controlling for the influence of habitual coping with humor, coping by disengagement, and global self-esteem.
Different Physiologic Pathways Trichostatin A and Ascorbic Acid Assist in the Development of Porcine Handmade Cloned Embryos via

The objective was to determine the effects of ascorbic acid (AA), trichostatin A (TSA), and their combined treatment (TA) on reprogramming and development of cloned porcine embryos. Embryos treated with AA (50 and 100 mg/mL) had a higher blastocyst rate than controls (49.6% and 44.0% vs 30.7%, P < .05). Blastocyst rates of handmade cloned (HMC) embryos were nearly 60% in both the 30 and 40 nmol/L TSA treatment groups, which were higher (P < .05) than the control (29.4%). The TA treatment groups had a higher blastocyst rate compared with the AA treatment alone (58.9% vs 43.5%, P < .05). Histone acetylation was much higher in the TSA and TA treatments (primarily in 2and 4-celled embryos) but was not significantly different between AA-treated and untreated embryos. Both AA and TA treatments reduced apoptotic rates of blastocysts. In conclusion, AA supplementation improved blastocyst development in porcine HMC embryos mainly by a traditional antioxidant pathway rather than by cellular reprogramming.
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Background: We aimed to gain new insights into the pathogenesis of sporadic ALS (sALS) through a comprehensive proteomic analysis. Methods: Protein profiles of the anterior and posterior horn in post-mortem spinal cord samples of 10 ALS patients and 10 controls were analysed using 2D-differential gel electrophoresis. The identified protein spots with statistically significant level changes and a spot ratio42.0 were analysed by LC-MS/MS. Results: In the posterior horn only 3 proteins were differentially expressed. In the anterior horn, 16 proteins with increased levels and 2 proteins with decreased levels were identified in ALS compared to controls. The identified proteins were involved in mitochondrial metabolism, calcium homeostasis, protein metabolism, glutathione homeostasis, protein transport and snRNP assembly. The two proteins with decreased levels, ATP5D and calmodulin, were validated by Western blot and immunostaining. Immunohistochemical and immunofluorescent double staining of ATP5D and synaptophysin showed that the reduction of ATP5D was most pronounced at synapses. Conclusions: We speculate that mitochondrial dysfunction in synaptic clefts could play an important role in sALS pathogenesis. A similar approach revealed decreased calmodulin expression mainly in the neuronal body and dendrites of ALS patients. These findings contribute to a deeper understanding of the disease process underlying ALS.
XMMFITCAT: The XMM-Newton spectral-fit database

The XMM-Newton spectral-fit database (XMMFITCAT) is a catalogue of spectral fitting results for the source detections within the XMM-Newton Serendipitous source catalogue with more than 50 net (background-subtracted) counts per detector in the 0.5-10 keV energy band. Its most recent version, constructed from the latest version of the XMM-Newton catalogue, the 3XMM Data Release 4 (3XMM-DR4), contains spectral-fitting results for $\gtrsim$ 114,000 detections, corresponding to $\simeq$ 78,000 unique sources. Three energy bands are defined and used in the construction of XMMFITCAT: Soft (0.5-2 keV), Hard (2-10 keV), and Full (0.5-10 keV) bands. Six spectral models, three simple and three more complex models, were implemented and applied to the spectral data. Simple models are applied to all sources, whereas complex models are applied to observations with more than 500 counts (30%). XMMFITCAT includes best-fit parameters and errors, fluxes, and goodness of fit estimates for all fitted models. XMMFITCAT has been conceived to provide the astronomical community with a tool to construct large and representative samples of X-ray sources by allowing source selection according to spectral properties, as well as characterise the X-ray properties of samples selected in different wavelengths. We present in this paper the main details of the construction of this database, and summarise its main characteristics.
Severity Scores Performance in Neurocritical Care: A Retrospective Cohort Study

Severity scores have wide spread use in intensive care as surrogate markers of disease severity, benchmarking and resource allocation. They are derived from certain cohorts and should go a validation process before their general use in other populations. Nevertheless, they may loss accuracy and prognosis predictability overtime and in different settings. Therefore, constant assess of score’s performance is crucial. In this study, we evaluated APACHE II, SAPS 3 and SOFA discrimination and calibration for mortality in a cohort of neurosurgical and neurological patients. Although all have showed good discrimination, APACHE II had a better calibration compared to the others. Hence, our data suggests that APACHE II is a good prognostic model for neurocritical patients.
Messenger RNA in Human Breast Cancer Cells Bcl-2 The Nucleolin Targeting Aptamer AS 1411 Destabilizes

We sought to determine whether nucleolin, a bcl-2 mRNAbinding protein, has a role in the regulation of bcl-2 mRNA stability in MCF-7 and MDA-MB-231 breast cancer cells. Furthermore, we examined the efficacy of the aptamer AS1411 in targeting nucleolin and inducing bcl-2 mRNA instability and cytotoxicity in these cells. AS1411 at 5 Mmol/L inhibited the growth of MCF-7 and MDA-MB-231 cells, whereas 20 Mmol/L AS1411 had no effect on the growth rate or viability of normal MCF-10A mammary epithelial cells. This selectivity of AS1411 was related to a greater uptake of AS1411 into the cytoplasm of MCF-7 cells compared with MCF-10A cells and to a 4-fold higher level of cytoplasmic nucleolin in MCF-7 cells. Stable siRNA knockdown of nucleolin in MCF-7 cells reduced nucleolin and bcl-2 protein levels and decreased the halflife of bcl-2 mRNA from 11 to 5 hours. Similarly, AS1411 (10 Mmol/L) decreased the half-life of bcl-2 mRNA in MCF-7 and MDA-MB-231 cells to 1.0 and 1.2 hours, respectively. In contrast, AS1411 had no effect on the stability of bcl-2 mRNA in normal MCF-10A cells. AS1411 also inhibited the binding of nucleolin to the instability element AU-rich element 1 of bcl-2 mRNA in a cell-free system and in MCF-7 cells. Together, the results suggest that AS1411 acts as a molecular decoy by competing with bcl-2 mRNA for binding to cytoplasmic nucleolin in these breast cancer cell lines. This interferes with the stabilization of bcl-2 mRNA by nucleolin and may be one mechanism by which AS1411 induces tumor cell death. [Cancer Res 2008;68(7):2358–65]
Internet Financial Reporting and Corporate Governance in Malaysia

This paper examined the association between corporate governance mechanisms, ownership structures, Internet visibility and Internet financial reporting. This paper argues that the adoption of technological-based innovation may involve more complex factors than considered by agency theory. Institutional theory was used to generate hypotheses about factors specific to Malaysia context, since the companies may adopt technological-based innovation when seeking for legitimacy during the increasing institutionalization process. The researcher examined the contents of listed companies' Web sites by adapting the richer and more comprehensive disclosures/attributes index from FASB (2000). The results in the regression model show Internet financial reporting is positively significantly related to independent non-executive directors, directors with accounting and business qualification, board size and shareholders numbers. Audit committee with financial and accounting qualification is also positively significantly associated with Internet visibility. These findings show that competent directors and accounting professional are establishing good reporting practices to create homogeneous organizational practices in response to uncertainty in technology. This process is in line with the argument of mimetic isomorphisms under the institutional theory. Following the corporate governance reforms, the companies are facing pressure and almost obliging them to disseminate information by Internet in seeking organizational legitimacy, so that capital market does not interpret the absence of information as a sign of lack of accountability and transparency. In addition, Malaysia is an emerging economy nation, which, on the global state, is under coercive pressure, normative and mimetic, institutionalizing expectation from the global capital markets. All these pressures can be identified as determinants that have affected the adoption of Internet reporting. The level of adoption for Internet reporting at the organizational level will be affected by the regulatory system's effectiveness and organizations' willingness to make a positive response to institutional pressure. This paper highlights important policy implications by showing the applicability of institutional theory in the contexts that have limited studies previously.
A study on students ’ satısfactıon based on qualıty standards of accedıtatıon ın hıgher educatıon

Quality standards are evaluated by the Higher Educational Institutions by self evaluation at different levels and are also assessed by external agencies. Application of quality standards in administrative practices have been associated with the quality of higher education. To improve the quality of administrative practices, evaluation scales are applied and the outcomes in terms of Quality perceived by the students and the higher level of satisfaction is evaluated. It is observed that the quality of ımplementation of standards and administrative practices adopted in various institutions needs care and consideration. There is lack of quality because all the policies and standards are adopted to the maximum in terms of mission and vision and the process of quality achieved is not adequate and permanent. Even-though accreditation provides quality assurance that the academic aims and objectives of the institution are honestly pursued and effectively achieved by the resources available, and the institutions may demonstrate the capabilities of ensuring effectiveness of the educational standards during the validity period, the lack of quality in terms of satisfactory level of students is observed in appropriate scales. In this paper findings of quality are evaluated using the same common factors used by accreditation.
The Potency of Trigona ’ s Propolis Extract in Diabetic Mice 263 2 . 2 . 2 Alloxan Monohydrate

Hyperglycemia has been proven to increase oxidative stress due to the production of reactive oxygen species (ROS) that exceed the capabilities of the natural antioxidant defenses, causing a deficiency in insulin receptors and insulin resistance. In this study, the effect of propolis on ROS was observed. Fifty five (55) male mice (Mus musculus SW.) were divided into 5 groups, i.e. KN (normal control), KDM (diabetes control), and P1, P2, P3. Propolis solution 50, 100 and 175 mg/kg bw was given to groups P1, P2 and P3 respectively, while distilled water was given to groups KN and KDM by oral gavage for 21 days. Density of ROS was measured every 7 days, while measurement of plasma insulin was carried out every 3 days. The results show that the density of ROS in the groups treated with propolis was lower than in the KDM group. However, the plasma insulin levels in the propolis groups were higher than in the KDM group. It was concluded that propolis can decrease ROS density and causes an increase in plasma insulin levels.
Maturity of Strategic Management in Organizations

There is some ambivalence with regard to how to improve strategic management of organizations. On the one hand, the example of big companies emphasizes the need for formalization and good organization of strategic management process. On the other hand, the example of small companies draws attention to such qualities as entrepreneurship, flexibility and adaptability. The concept of strategic management maturity embraces both of these priorities. In this paper, a framework for strategic management maturity has been designed. Strategic management maturity was defined as a resultant of: strategic management process maturity and leadership maturity. Theoretical framework was tested on a sample of 150 Polish enterprises.
Determination of concentration of heavy metals in fish from sea port of Zanzibar by energy dispersive x-ray fluorescence (EDXRF)

Seafood is the major source of food for a large number of people residing in the coastal areas of Zanzibar. It has been reported that the seafood are a connecting link for the transfer of toxic heavy metals in human beings. The present study assessed the metal concentration upon sample species of fish along the coast Sea Port of Zanzibar. Fish samples (namely changu, sardine, baracout and tuna fish) were the ideal species for the assessment study on effects of heavy metal contamination in aquatic organisms. They were collected at the Sea Port and the concentrations of the assessed metals were determined using Energy Dispersive X-ray Fluorescence (EDXRF). Concentrations of Fe, Pb, Cr, Ni, As, Cu and Zn were found to be higher in sardine whilst Hg was found to be higher in changu specie. Concentrations of Cd and Mn were found to be below the detection limits in all sample species but higher in mussels. Whereas Hg was only detected in changu species. Comparing the data from this study to data from other studies in other regions, the concentrations of Fe, Cr and As in different species of fishes collected was quite higher than the values reported in the literature. The results of this study indicated that As, Hg and Cr were higher in fish than WHO/FAO (2004). Keywords: EDXRF, X-Rays, Fish, Pollution studies, Environment
formaldehyde in cosmetic industry Assessment of lipid peroxidation and p 53 as a biomarker of carcinogenesis among workers exposed to

Despite the wide use of cosmetic products, they exert a number of health effects on tissues ranging from irritation to cancer. Our study aimed at assessing the effect of formaldehyde on lipid peroxidation and verifying the susceptibility to carcinogenesis using p53 as a biomarker among workers exposed to formaldehyde in cosmetic industry. Our entire exposed group (n1⁄4 40) and the controls (n1⁄4 20) were subjected to estimation of formate in urine, serum malondialdehyde (MDA), and p53. Also, complete blood picture, liver, and kidney function tests were carried out. The study revealed significant increase in the levels of formate, MDA, and p53 in the exposed group compared with their control group. Our results showed that workers in cosmetic industry had significant exposure to formaldehyde. Furthermore, the study pointed to the negative impact of formaldehyde as a cause of oxidative stress and suspicious carcinogen.
Food and Feeding Habits of Two-Bar Seabream, Acanthopagrus bifasciatus (Forsskål, 1775) from Southern Red Sea, Egypt

Seabreams (Sparidae) are common coastal fish specie inhabiting tropical and temperate waters throughout the world. Up to date, 117 of 15 genera have been ascribed to this family (Chiba et al., 2009; Iwatsuki and Heemstra, 2011 a,b). Seabreams represent one of the most important fish families in the Red Sea. Its ARTICLE INFO Article History: Received: April. 2017 Accepted: April. 2017 Available online: May 2017
Prevalence of Metabolic Syndrome in Adult Population of District of Tetovo in the Northwest Region of the Republic of Macedonia

Objective: To estimate the prevalence of metabolic syndrome (MetS) and its separate components in the adult population of the district of Tetovo. Methods: Total of 630 subjects aged over 18 years were selected at random, from the primary healthcare register, to constitute a representative sample of a population in the district of Tetovo, adjusted for age and sex. MetS is defined according to the definition of the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATPIII). Results: The prevalence of MetS in the district of Tetovo was 28.25%. It was significantly higher in women than in men (34.06% versus 22.26%, p=0.004). The largest number of people with MetS living in rural areas (31.32% versus 23.60%, p=0.002). Of the particular components of MetS, 52.06% of the population had increased arterial blood pressure, 46.35% reduced values of high-density lipoprotein cholesterol (HDL-C) and 43.17% abdominal adiposity (AA). In women population, more dominated was abdominal adiposity (59.38% and 26.54%, p=0.000), in men more dominated was increased arterial blood pressure (53.44% and 50.65%, p=0.48). Conclusion: The prevalence of MetS in our population is high, particularly in women. The prevalence rates for arterial hypertension and abdominal obesity are among the highest reported for the region. Advice on diet and change in lifestyles, in addition to the pharmacological treatment of this category, would contribute to the prevention of cardiovascular disease, type II diabetes and complications from these diseases.
The Effect of Dietary Supplementation of Feather Meal on the Performance and Muscular Taurine Contents in Growing-finishing Pigs

An experiment was conducted to investigate the effects of dietary supplementation of feather meal (FM) on the performance of pigs and taurine content in pork. A total of 135 cross-bred (L×Y×D) pigs, weighing an average 46 kg, were assigned to five dietary treatments; Control, 3% FM supplemented diet (3% FM), 3% FM and 10 ppm pyridoxin supplemented diet (3% FM- pyridoxin), 6% FM supplemented diet (6% FM) and 6% FM and 10 ppm pyridoxine supplemented diet (6% FM-pyridoxin). Each treatment had 3 replications of 9 pigs (4 gilts and 5 barrows) each. Pigs were fed for 11 weeks under a phase feeding program which consisted of grower (0-3 week), grow-finisher (4-8 week) and finisher (9-11 week) periods. During the whole feeding period, ADG and ADFI of pigs fed FM treatments tended to increase in general compared to the control. Feed conversion ratio (feed/gain) of the control was significantly (p<0.05) lower than FM treatments. Taurine content of the control was highest in heart muscle (1,393.8 ppm) followed by liver (647.3 ppm), tenderloin (601.2 ppm), ham (462.4 ppm) and loin (375.8 ppm). Taurine contents of heart, tenderloin, ham and loin were significantly (p<0.05) increased by FM treatments. Taurine content was highest in the 6% FM-pyridoxin treatment. Taurine content of heart, tenderloin, ham and loin on 6% FM-pyridoxin supplementation were increased by 91%, 23%, 27% and 29%, respectively, compared with the control. Sensory tests of the pork showed that there was no consistent response among the treatments. In conclusion, supplementation of FM and pyridoxin to a pig diet can increase taurine content of the pork. (Key Words : Taurine, Feather Meal, Pyridoxin, Pork)