Miracle-dz/UniFAR-FTUs huggingface dataset:
Metachronous Gastric Cancer Following Curative Endoscopic Resection of Early Gastric Cancer

This review article summarizes knowledge about metachronous gastric cancer (MGC) occurring after curative endoscopic resection (ER) of early gastric cancer (EGC), treatment outcomes of patients who developed MGC, and efficacy of Helicobacter pylori eradication to prevent MGC. The incidence of MGC following curative ER increases over time and is higher than in patients undergoing gastrectomy. Increasing age and multifocal EGC are independent risk factors for developing MGC. An MGC following curative ER is usually a small (<20 mm) and differentiated intramucosal cancer. Most MGC lesions are found at an early stage on semiannual or annual surveillance endoscopy and are successfully treated by further ER, with excellent long-term outcomes. Eradication of H. pylori may reduce the risk of MGC following ER of EGC, but further prospective studies with long-term outcomes are required. Surveillance endoscopy following gastric ER should be continued indefinitely, due to the risk of MGC even after successful H. pylori eradication. Risk stratification and tailored endoscopic surveillance schedules need to be developed.
Organizations' Information Security Policy Compliance: Stick or Carrot Approach?

Companies' information security efforts are often threatened by employee negligence and insider breach. To deal with these insider issues, this study draws on the compliance theory and the general deterrence theory to propose a research model in which the relations among coercive control, which has been advocated by scholars and widely practiced by companies; remunerative control, which is generally missing in both research and practice; and certainty of control are studied. A Web-based field experiment involving real-world employees in their natural settings was used to empirically test the model. While lending further support to the general deterrence theory, our findings highlight that reward enforcement, a remunerative control mechanism in the information systems security context, could be an alternative for organizations where sanctions do not successfully prevent violation. The significant interactions between punishment and reward found in the study further indicate a need for a more comprehensive enforcement system that should include a reward enforcement scheme through which the organizational moral standards and values are established or reemphasized. The findings of this study can potentially be used to guide the design of more effective security enforcement systems that encompass remunerative control mechanisms.
A consistent prepositional logic without any finite models

Some propositional logics (e.g. the classical system) can be characterized by a finite model, while others (e.g. Heyting's) which have the finite model property (FMP) can be characterized by an infinite set of finite models. Still others (e.g. certain extensions of Heyting's logic) which lack the FMP can only be characterized by a set of models, at least one of which is infinite. Yet all these logics admit finite models even though they may not be characterized by them. (For example, they all admit the 2-element Boolean algebra as a model in the sense that all their theorems are valid on that algebra when the propositional connectives are interpreted in the usual manner.) The object of the present paper is to give a (not too artificial) example of a propositional logic which is consistent and which admits only infinite models. It therefore lacks the FMP in a very strong sense. Such a propositional logic, I shall call hyperinfinite. The existence of hyperinfinite logics was already plausible from a result in abstract algebra which says that there are varieties of algebras of which the only finite element is the trivial algebra (see [3]). I wish to thank Professor A. S. Troelstra, Amsterdam, for comments on an early version of this paper. The constructive criticism of two anonymous referees has also been useful. The hyperinfinite propositional logic to be described is obtained from Positive Logic—the negative-free part of Heyting's logic—by adjoining certain axioms which govern the use of a unary modal connective.
Intraductal Tubulopapillary Neoplasms of the Pancreas Distinct From Pancreatic Intraepithelial Neoplasia and Intraductal Papillary Mucinous Neoplasms

We have encountered cases of unusual intraductal pancreatic neoplasms with predominant tubulopapillary growth. We collected data on 10 similar cases of “intraductal tubulopapillary neoplasms (ITPNs)” and analyzed their clinicopathologic and molecular features. Tumor specimens were obtained from 5 men and 5 women with a mean age of 58 years. ITPNs were solid and nodular tumors obstructing dilated pancreatic ducts and did not contain any visible mucin. The tumor cells formed tubulopapillae and contained little cytoplasmic mucin. The tumors exhibited uniform high-grade atypia. Necrotic foci were frequently observed, and invasion was observed in some cases. The ITPNs were immunohistochemically positive for cytokeratin 7 and/or cytokeratin 19 and negative for trypsin, MUC2, MUC5AC, and fascin. Molecular studies revealed abnormal expressions of TP53 and SMAD4 in 1 case, but aberrant expression of β-catenin was not observed. No mutations in KRAS and BRAF were observed in the 8 cases that were examined. Eight patients are alive without recurrence, 1 patient died of liver metastases, and 1 patient is alive but had a recurrence and underwent additional pancreatectomy. The mitotic count and Ki-67 labeling index were significantly associated with invasion. All the features of ITPN were distinct from those of other known intraductal pancreatic neoplasms, including pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasm, and the intraductal variant of acinar cell carcinoma. Intraductal tubular carcinomas showed several features that were similar to those of ITPN, except for the tubulopapillary growth pattern. In conclusion, ITPNs can be considered to represent a new disease entity encompassing intraductal tubular carcinoma as a morphologic variant.
Laxative management in ambulatory cancer patients on opioid therapy: a prospective, open-label investigation of polyethylene glycol, sodium picosulphate and lactulose.

Constipation and the laxatives polyethylene glycol (PEG), sodium picosulphate (SPS) and lactulose (L) were investigated in outpatients with cancer and on opioid therapy. Randomly selected patients were enrolled in a prospective, controlled, open-label trial. Endpoints were number of patients taking laxatives >28 days, number of patients with a stool-free interval >72 h (sfi72), dosage, numerical rating scale (NRS) for constipation, and European Organization for Research and Treatment of Cancer (EORTC) Quality of Life (QoL) questionnaire scores. The 348 patients had comparable demographic and medical data. In this ambulatory population, mobility scores remained unaffected. Constipation incidence was 5.7%, with sfi72 42, mean NRS 2.3557 and mean QoL 2.1. A total of 53.2% discontinued their laxative medication. Laxative use correlated with higher opioid usage (morphine-equivalent mg/day: no laxative 98.2, SPS 128.2, PEG 139.9, L 154.5). PEG was the most frequently prescribed laxative (PEG 27.3%, SPS 10.3%, L 9.2%). PEG (sfi72 12.6%, NRS 2.2, QoL 2.1) and SPS (sfi72 11.1%, NRS 2.7, QoL 2.2) proved more effective than L (sfi72 15.5%, NRS 3.8, QoL 2.5). In spite of opioid therapy, the incidence of constipation was low in these ambulatory cancer pain patients at an early disease stage. For prevention of constipation, PEG or SPS is recommended instead of L.
phiC31 Integrase-Mediated Site-Specific Recombination in Barley

The Streptomyces phage phiC31 integrase was tested for its feasibility in excising transgenes from the barley genome through site-specific recombination. We produced transgenic barley plants expressing an active phiC31 integrase and crossed them with transgenic barley plants carrying a target locus for recombination. The target sequence involves a reporter gene encoding green fluorescent protein (GFP), which is flanked by the attB and attP recognition sites for the phiC31 integrase. This sequence disruptively separates a gusA coding sequence from an upstream rice actin promoter. We succeeded in producing site-specific recombination events in the hybrid progeny of 11 independent barley plants carrying the above target sequence after crossing with plants carrying a phiC31 expression cassette. Some of the hybrids displayed fully executed recombination. Excision of the GFP gene fostered activation of the gusA gene, as visualized in tissue of hybrid plants by histochemical staining. The recombinant loci were detected in progeny of selfed F1, even in individuals lacking the phiC31 transgene, which provides evidence of stability and generative transmission of the recombination events. In several plants that displayed incomplete recombination, extrachromosomal excision circles were identified. Besides the technical advance achieved in this study, the generated phiC31 integrase-expressing barley plants provide foundational stock material for use in future approaches to barley genetic improvement, such as the production of marker-free transgenic plants or switching transgene activity.
Liver enzymes and trace elements in the acute phase of sickle cell anaemia.

BACKGROUND Trace elements are required for the performance of numerous functions of immune cells. It is not clear whether levels of trace elements are elevated and whether there is a relationship between the levels of liver enzymes and trace elements in patients with sickle cell anaemia in crisis. OBJECTIVE To compare the plasma levels of liver enzymes and trace elements in non sickle cell anaemia (NSCA), sickle cell anaemia subjects in the steady state (SCASS) and sickle cell anaemia patients in crisis (SCAC). METHODS Haematological parameters, liver enzymes and trace elements were determined in 20 NSCA subjects, 20 SCASS subjects and 18 SCAC subjects. Variables studied included aspartate aminotransferase (AST) , alanine aminotransaminase (ALT), alkaline phosphatase (ALP), and the trace elements copper, zinc, and manganese. RESULTS Levels of liver enzymes were higher in the SCAC subjects than in the NSCA or SCASS subjects (p<0.001). Plasma Cu++, Zn++ and Mn++ were also higher in the SCAC subjects than in the NSCA or SCASS subjects (p<0.001). Correlationships were high and strong between AST and ALT (r=+0.7; p=0.03), AST and ALP (r=+0.9; p=0.001), Zn++ and Fe++ (r=+0.9; p=0.001) in SCAC. CONCLUSION During crisis in sickle cell anaemia, liver enzymes, as well as the trace elements of Cu++, Zn++ and Mn++ are increased; levels of aspartate aminotransaminase are strongly correlated with those of ALT and ALP. Levels of liver enzymes do not appear to be related to those of the trace elements in painful sickle cell crisis.
Hierarchical Structure and Search in Complex Organizations

Organizations engage in search whenever they perform nonroutine tasks, such as the definition and validation of a new strategy, the acquisition of new capabilities, or new product development. Previous work on search and organizational hierarchy has discovered that a hierarchy with a central decision maker at the top can speed up problem solving, but possibly at the cost of solution quality compared with results of a decentralized search. Our study uses a formal model and simulations to explore the effect of an organizational hierarchy on solution stability, solution quality, and search speed. Three insights arise on how a hierarchy can improve organizational search: (1) assigning a lead function that “anchors” a solution speeds up problem solving; (2) local solution choice should be delegated to the lowest level; and (3) structure matters little at the middle management level, but it matters at the front line; front-line groups should be kept small. These results highlight the importance for every organization of adapting its hierarchical structure to its search requirements.
Spatial Variability in a Successional Plant Community: Patterns of Nitrogen Availability

We examined the spatial variability of N mineralization, nitrification, and denitrification at a resolution of 1 m over a 0.5-ha portion of an old field in southeast Michigan. Net mineralization and nitrification rates were estimated from changes in am- monium and nitrate during 45-d laboratory incubations of soil from >300 individual sample locations. Denitrification was estimated from nitrous oxide accumulation rates during 24-h incubations of intact cores (n = 252) under acetylene atmospheres at a pressure of 10 kPa. We used geostatistical procedures to characterize the spatial distributions of these and other soil variates. Semivariograms for all three N transformations showed a high degree of spatial de- pendence among points sampled within 1-40 m of one another. Nugget variances were 27-37% of structural variances, indicating that most of the variation within the sample populations for these rates could be attributed to spatial autocorrelation at a scale > 1 m. Isopleths calculated using punctual kriging algorithms show a nonuniform distribution of these transformations across the field. High rates of all processes occurred in swales on the northern edge of the sample area, but also occurred elsewhere in the field on drier, more level sites. These results indicate that spatial characteristics of the measured nitrogen transfor- mations in this old field are complex, and that only some of this complexity is associated with surface topography. Whether spatial complexity affects or mainly reflects plant com- munity structure is not known, but this small-scale heterogeneity may influence existing plant and microbial population dynamics and should be considered by those attempting to understand community dynamics or to quantify ecosystem-level nutrient fluxes.
N-Glycopeptide Profiling in Arabidopsis Inflorescence*

This study presents the first large-scale analysis of plant intact glycopeptides. Using wheat germ agglutinin lectin weak affinity chromatography to enrich modified peptides, followed by electron transfer dissociation (ETD)1 fragmentation tandem mass spectrometry, glycan compositions on over 1100 glycopeptides from 270 proteins found in Arabidopsis inflorescence tissue were characterized. While some sites were only detected with a single glycan attached, others displayed up to 16 different glycoforms. Among the identified glycopeptides were four modified in nonconsensus glycosylation motifs. While most of the modified proteins are secreted, membrane, endoplasmic reticulum (ER), or Golgi-localized proteins, surprisingly, N-linked sugars were detected on a protein predicted to be cytosolic or nuclear.
Inhibitory Mechanisms of Neural and Cognitive Control: Applications to Selective Attention and Sequential Action

This paper discusses the role of inhibition in neural and cognitive control, in particular its role in selective processes in perception and action. We first review neuroanatomical and physiological evidence that cortical control is mediated by a variety of local-circuit inhibitory neurons, distributed throughout all layers and areas of the cortex. We then consider the use of inhibition in control processes in behavioral neural network models, focusing on two areas: selective attention and sequential action. Relations between the architecture and dynamics of these models and relevant neurological findings are discussed. We conclude that a full understanding of inhibitory control of mental functioning will require the integration of data from both the behavioral and neural levels, and that formal neural network models can play an important role in bridging this epistemological divide.
Anorexia nervosa and gender identity disorder in biologic males: a report of two cases.

UNLABELLED Gender identity disorder is a rare disorder of uncertain etiology. The emphasis on body shape in this disorder suggests that there may be an association with anorexia nervosa. METHOD We report two cases of anorexia nervosa and gender identity disorder in biologic males who presented to an eating disorders service. RESULTS One was treated successfully as an outpatient and subsequently underwent gender reassignment surgery. The other patient required admission and prolonged psychotherapy. DISCUSSION Differences between the two cases are discussed. Issues of gender identity should be considered in the assessment of male patients presenting with anorexia nervosa.
The effects of heavy-duty machinery on the formation of pseudo-knapping debitage in Stone Age cultural landscapes

Abstract The risk to surface archaeological sites posed by heavy machinery has grown significantly, and stone-tool assemblages are particularly susceptible to alteration that may be difficult to recognise. Indeed, the impact of industrial machines on surface scatters of lithic material has not yet been explored. Here, an analytical experiment is used to explore the ways in which machine action can affect a test assemblage resembling a typical Stone Age scatter. The results demonstrate that while formal tool types are not easily replicated through machine action, the creation of assemblages that resemble archaeological debitage poses a much greater challenge for archaeologists.
Increased IRP1 and IRP2 RNA binding activity accompanies a reduction of the labile iron pool in HFE‐expressing cells *

Iron regulatory proteins (IRPs), the cytosolic proteins involved in the maintenance of cellular iron homeostasis, bind to stem loop structures found in the mRNA of key proteins involved iron uptake, storage, and metabolism and regulate the expression of these proteins in response to changes in cellular iron needs. We have shown previously that HFE‐expressing fWTHFE/tTA HeLa cells have slightly increased transferrin receptor levels and dramatically reduced ferritin levels when compared to the same clonal cell line without HFE (Gross et al., 1998 , J Biol Chem 273:22068‐22074). While HFE does not alter transferrin receptor trafficking or non‐transferrin mediated iron uptake, it does specifically reduce 55Fe uptake from transferrin (Roy et al., 1999 , J Biol Chem 274:9022–9028). In this report, we show that IRP RNA binding activity is increased by up to 5‐fold in HFE‐expressing cells through the activation of both IRP isoforms. Calcein measurements show a 45% decrease in the intracellular labile iron pool in HFE‐expressing cells, which is in keeping with the IRP activation. These results all point to the direct effect of the interaction of HFE with transferrin receptor in lowering the intracellular labile iron pool and establishing a new set point for iron regulation within the cell. J. Cell. Physiol. 190: 218–226, 2002. © 2002 Wiley‐Liss, Inc.
Methods for Estimating the Critical Shear Stress of Individual Fractions in Mixed-Size Sediment

Two methods are commonly used to estimate the critical shear stress of individual fractions in mixed-size sediment, one using the largest grain displaced, the other using the shear stress that produces a small value of transport rate for each fraction. The initial-motion results produced by the two methods are typically different: largest-grain critical shear stresses vary with roughly the square root of grain size, and reference transport critical shear stresses show little variation with grain size. Comparison of the two methods is seldom possible because both methods can rarely be applied to the same data. The one case known for which both methods can be used suggests that the typical differences in initial-motion results reflect more methodological influence than real differences in the initial motion of different sediments. Although the two classes of methods may not be directly compared, a general definition of initial-motion in mixed-size sediment is presented that allows the characteristic differences between the results to be explained in terms of sampling and scaling considerations inherent in the mixed-size initial-motion problem. The initial-motion criterion defined also provides a rational basis for collecting comparable and reproducible data using the two classes of method.
A Multicenter Outcomes Analysis of Children With Severe Rhino/Enteroviral Respiratory Infection*

Objectives: To investigate the impact of human rhino/enteroviruses on morbidity and mortality outcomes in children with severe viral respiratory infection. Design: Retrospective cohort study. Setting: The ICU, either PICU or cardiac ICU, at three urban academic tertiary-care children’s hospitals. Patients: All patients with laboratory-confirmed human rhino/enteroviruses infection between January 2010 and June 2011. Interventions: We captured demographic and clinical data and analyzed associated morbidity and mortality outcomes. Measurements and Main Results: There were 519 patients included in our analysis. The median patient age was 2.7 years. The median hospital and ICU lengths of stay were 4 days and 2 days, respectively. Thirty-four percent of patients had a history of asthma, and 25% of patients had a chronic medical condition other than asthma. Thirty-two percent of patients required mechanical ventilation. Eleven patients (2.1%) did not survive to hospital discharge. The rate of viral coinfection was 12.5% and was not associated with mortality. Predisposing factors associated with increased mortality included immunocompromised state (p < 0.001), ICU admission severity of illness score (p < 0.001), and bacterial coinfection (p = 0.003). Conclusions: There is substantial morbidity associated with severe respiratory infection due to human rhino/enteroviruses in children. Mortality was less severe than reported in other respiratory viruses such as influenza and respiratory syncytial virus. The burden of illness from human rhino/enteroviruses in the ICU in terms of resource utilization may be considerable.
Car Accident Detection and Notification System using Smartphone

Every day around the world, a large percentage of people die from traffic accident injuries. An influential indicator of survival rates after detecting the accident is the time between the occurrence of the accident and the arrival of emergency responders to the scene. Reductions in this time, in turn, may affect the numbers of fatalities, and this is achieved through using automatic traffic accident detection and notification systems which are either built-in the modern vehicles or available in the roads. This book highlights the state of arts for the existing automatic traffic accident detection and notification systems and reviews smartphone's interesting features that are motivated the researchers to develop smartphone based accident detection and notification systems, to provide an efficient solution in case the lack, complexity, cost, and the maintenance of other automatic accident detection systems. Most of the smartphone based accident detection systems rely on the high speed of the vehicle and the G-Force value to detect an accident. Hence, in addition to the high speed accident detection, this book concentrated on low speed car accident detection also.
Cellular parkin mutants are soluble under non-stress conditions

The parkin gene encodes an E3 ubiquitin ligase and loss of function mutations herein are the most frequent cause of early-onset Parkinson's disease. Reports have suggested that aggregation of mutant protein is the cause of the loss of function. We established stably transfected SH-SY5Y dopaminergic cell lines expressing wild-type and mutant parkin proteins. All the mutant proteins were soluble but could be rendered insoluble by subjecting the cellsto stress by proteasomal inhibition, treatment with oxidants and upon transient expression of the mutant proteins. A functional assay demonstrated that the R42P mutant retained functional activity in contrast to the W453stop mutant. Accordingly, the functional impairment by the mutations is not simply caused by turning the proteins insoluble.