Miracle-dz/UniFAR-FTUs huggingface dataset:
Oxidation of Fe(II) leads to increased C‐2 methylation of pentacyclic triterpenoids in the anoxygenic phototrophic bacterium Rhodopseudomonas palustris strain TIE‐1

Hopanoids are among the most widespread biomarkers of bacteria that are used as indicators for past and present bacterial activity. Our understanding of the production, function, and distribution of hopanoids in bacteria has improved greatly, partly due to genetic, culture‐independent studies. Culture‐based studies are important to determine hopanoid function and the environmental conditions under which these compounds are produced. This study compares the lipid inventory of Rhodopseudomonas palustris strain TIE‐1 under anoxic photoautotrophic conditions using either H2 or Fe(II) as electron donor. The high amount to which adenosylhopane is produced irrespective of the used electron donor suggests a specific function of this compound rather than its exclusive role as an intermediate in bacteriohopanepolyol biosynthesis. C‐2 methylated hopanoids and tetrahymanol account for as much as 59% of the respective C‐2 methylated/non‐methylated homologs during growth with Fe(II) as electron donor, as compared with 24% C‐2 methylation for growth with H2. This observation reveals that C‐2 methylated hopanoids have a specific function and are preferentially synthesized in response to elevated Fe(II) concentrations. The presence of C‐2 methylated pentacyclic triterpenoids has commonly been used as a biosignature for the interpretation of paleoenvironments. These new findings suggest that increased C‐2 methylation may indicate anoxic ferrous conditions, in addition to other environmental stressors that have been previously reported.
An empirical research on E-recruitment systems base on the technology acceptance model

This paper empirically studies factors determining the use of E-recruitment systems. The Technology Acceptance Model(TAM)is used as the main framework and combines with other three factors. Firstly, a hypothetical model was given, which was derived from the integration of TAM, subjective norm, perceived risk, perceived expenses, job pressure. Secondly, the structural equation modeling(SEM) technique was used to evaluate the causal model and confirmatory factor analysis was applied to examine the reliability and validity of the measurement model by collected data. Job pressure has significantly effect behavioral intention on e-recruitment. Finally, discussion and explanation about the result was put forward.
The influence of epidural volume extension on spinal block with hyperbaric or plain bupivacaine for Caesarean delivery.

BACKGROUND AND OBJECTIVE Epidural volume extension via a combined spinal-epidural is the enhancement of a small-dose intrathecal block by an epidural injection of physiological saline solution. We evaluated the effect of epidural volume extension on the combined spinal-epidural technique of providing spinal anaesthesia for Caesarean section with hyperbaric or plain 0.5% bupivacaine. METHODS Patients (n = 240) with height >163 cm received 9 mg and patients <163 cm received 8 mg of bupivacaine. Each study drug was combined with 20 mug fentanyl. Using the combined spinal-epidural technique, Group A (n = 60) received hyperbaric bupivacaine, and Group B (n = 60) received hyperbaric bupivacaine and 10 mL saline epidurally 5 min after subarachnoid injection. Group C (n = 60) received plain bupivacaine and Group D (n = 60) received plain bupivacaine and 10 mL saline epidurally 5 min after subarachnoid injection. An anaesthetist blinded to the anaesthetic solution injected examined the level of analgesia by the pinprick method and motor block with the modified Bromage scale for 30 min after subarachnoid injection, during the intraoperative period and subsequently every 15 min for 135 min during the recovery period. RESULTS Time to reach a sensory block at T4 was significantly shorter in Groups C and D than in Groups A (P = 0.003 and 0.017) and B (P = 0.006 and 0.048), respectively. During the intraoperative period, sensory block levels were significantly higher in Group C than in Group A. Recovery was similar in all groups; only onset was faster in Groups C and D. CONCLUSION There was no effect of epidural volume extension on the profile of spinal anaesthesia with the combined spinal-epidural technique for Caesarean section using hyperbaric or plain bupivacaine.
Hormonal imbalance and the sarcomata.

A series of 11 patients suffering front sarcoma of either soft tissues or bone, and of various ages (2–92 years), has been studied in our Unit. It was observed that in the majority of the postpubertal patients the serum level of human growth hormone (HGH, STH, somatotrophin) was elevated above the mean figure for the Australian population, estimated by radio-immuno-assay. This figure is 2.4 γγ/ml serum, with a range of 0.3–7.7 γγ/ml (Lazarus). In the sarcomatous patients, this level was exceeded in six of the nine postpubertal adults, but not in the prepubertal children, or in the very aged, or in those with quiescent lesions. Clinical improvement varying from regression to total disappearance was observed when the raised serum level was promptly reduced to lower levels.
THE RETINAL PULSE

IT is extraordinary how little is known on the subject of the retinal pulse. The textbook statements on the subject are meagre, and much that has been written is inaccurate. Bailliart's writings have recently stimulated an interest in the, subject, especially in France. Under the spell of this work, the writer has recently endeavoured to study the subject more closely than he had done before, and to strive to obtain some accurate and reliable information on-points 'which have hitherto.been nebulous and vague.
Pharmacokinetics and pharmacodynamics of bococizumab, a monoclonal antibody to PCSK9, after single subcutaneous injection at three sites [NCT 02043301]

AIM To characterize the single-dose pharmacokinetics (PK) and pharmacodynamics (PD) of bococizumab, a monoclonal antibody inhibiting proprotein convertase subtilisin/kexin type 9 (PCSK9), administered subcutaneously (s.c.) to the abdomen, thigh, or upper arm (NCT02043301). METHODS Seventy-five adults with low-density lipoprotein cholesterol (LDL-C) ≥130 mg/dL and not on background lipid-lowering therapy were randomized (1:1:1) to a single 150-mg s.c. dose of bococizumab administered to the abdomen, thigh, or upper arm. Blood samples for bococizumab and lipids were collected for 12 weeks postdose. RESULTS Plasma bococizumab concentration-time profiles and PK parameters were generally similar across injection sites. Mean maximum observed concentration (Cmax ) ranged from 8.14 to 11.9 μg/mL, and area under the concentration-time curve (AUCinf ) ranged from 160.3 to 198.9 µg∙day/mL. The median time to Cmax (Tmax ) ranged from 4.25 to 6.93 days. Similar LDL-C concentration-time profiles were observed across injection sites, with mean (% coefficient of variation) maximum reductions in LDL-C of -57.5% (15.8), -57.0% (25.9), and -55.0% (24.1) for the abdomen, thigh, and upper arm, respectively. Adverse events (AEs) were mostly mild and generally similar across injection sites. Commonly reported AEs were upper respiratory tract infection (9.3%), headache (6.7%), and injection site reaction (6.7%). One serious AE was reported (ischemic colitis), which was not considered related to study drug. CONCLUSIONS Similar PK profiles and robust LDL-C reductions were observed following a single 150-mg s.c. injection of bococizumab administered to the abdomen, thigh, or upper arm in untreated subjects with LDL-C ≥130 mg/dL. Bococizumab was generally well tolerated following a single 150-mg s.c. administration in this subject population.
Structure of the Methanococcus jannaschii Mevalonate Kinase, a Member of the GHMP Kinase Superfamily*

The mevalonate-dependent pathway is used by many organisms to synthesize isopentenyl pyrophosphate, the building block for the biosynthesis of many biologically important compounds, including farnesyl pyrophosphate, dolichol, and many sterols. Mevalonate kinase (MVK) catalyzes a critical phosphoryl transfer step, producing mevalonate 5′-phosphate. The crystal structure of thermostable MVK from Methanococcus jannaschii has been determined at 2.4 Å, revealing an overall fold similar to the homoserine kinase from M. jannaschii. In addition, the enzyme shows structural similarity with mevalonate 5-diphosphate decarboxylase and domain IV of elongation factor G. The active site of MVK is in the cleft between its N- and C-terminal domains. Several structural motifs conserved among species, including a phosphate-binding loop, have been found in this cavity. Asp155, an invariant residue among MVK sequences, is located close to the putative phosphate-binding site and has been assumed to play the catalytic role. Analysis of the MVK model in the context of the other members of the GHMP kinase family offers the opportunity to understand both the mechanism of these enzymes and the structural details that may lead to the design of novel drugs.
Moderators of response to sertraline versus placebo among recently abstinent, cocaine dependent patients: A retrospective analysis of two clinical trials

BACKGROUND AND OBJECTIVES Moderators of treatment response to serotonin reuptake inhibitor sertraline (SRT) for cocaine dependence were assessed in two randomized, double blind, placebo-controlled clinical trials. METHODS Generalized estimating equation modeling was performed on data from cocaine-dependent volunteers randomized to receive SRT or placebo (N = 126) who completed >2-week drug-free residential portions of the 12-week trials, in which subsequent outpatient treatment (weeks 3-12) included weekly cognitive behavioral therapy and thrice-weekly supervised urine toxicology. PRIMARY OUTCOME MEASURE Relapse (2 consecutive cocaine-positive or missing urines) following residential stay. Potential moderators included treatment, sex, age, race, depression measures, baseline cocaine urine result, and alcohol dependence diagnosis (ADDx). RESULTS Odds ratios (OR) for relapse showed placebo-treated participants were significantly more likely to relapse than SRT participants. Regardless of treatment condition, participants more likely to relapse were male, and those with lower Hamilton depression ratings, or baseline cocaine-negative urines. Older subjects or those with current ADDx had higher relapse risk than those without ADDx; however, treating older or ADDx participants with SRT reduced cocaine relapse more than placebo. DISCUSSION AND CONCLUSIONS Women or those with more severe cocaine use or depressive symptoms may have fewer cocaine relapses regardless of medication treatment. SRT at 200 mg reduced cocaine relapse more than placebo, especially in older participants or in those with comorbid ADDx. SCIENTIFIC SIGNIFICANCE SRT may be efficacious to support relapse prevention among cocaine-dependent patients in the context of brief residential followed by outpatient treatment, especially in older participants or those with comorbid alcohol/cocaine dependence. (Am J Addict 2017;26:807-814).
A Minimally Invasive Technique (“Healing Response”) to Treat Proximal ACL Injuries in Skeletally Immature Athletes

This study documents outcomes of athletically active, skeletally immature patients with proximal anterior cruciate ligament (ACL) tears treated with a non-reconstructive technique to promote healing ("healing response"). Between 1992 and 1998, 13 skeletally immature athletes with proximal ACL tears underwent a healing response procedure. Patients with previous ACL injury, other concurrent ligament pathology, and/or complete mid-substance ACL tears were excluded. Average preoperative KT-1000 arthrometer manual maximum difference for all patients was 5 mm (range: 3-10 mm). Preoperatively, all patients had a 1+ or 2+ pivot shift, and all patients reported knee function as abnormal or severely abnormal. Patients were followed prospectively with clinical examinations, KT-1000 testing, and subjective questionnaires. Three (23%) patients had a re-injury 30 to 55 months after the healing response and underwent subsequent ACL reconstruction. Subjective follow-up on the remaining 10 patients at an average of 69 months (range: 26-113 months) postoperatively indicated no patients experienced pain or giving way, and all considered their knee function normal. Average Lysholm score was 96, Tegner score was 8.5 (range: 7-10), and patient satisfaction at follow-up was 9.9 (1=very dissatisfied and 10=very satisfied). Clinical examination at least one year postoperatively was performed on 7 of 10 patients at 35 months (range: 12-63 months). Five patients had a negative pivot shift and 2 had a 1+ pivot shift. KT-1000 measurements improved to 2 mm (range: 0-3 mm). In the athletically active, skeletally immature patient, the healing response procedure can restore stability and knee function, with proper patient selection. In this study group, patients were very satisfied with the procedure and returned to a high level of sports and activities.
A study on variation-specific disputes that arise in road projects in Sri Lanka: a qualitative approach

Abstract With the rapid development in Sri Lanka, a number of highway projects are on the increase. Quite often, these projects suffer cost and time overruns predominantly because of variations. Although many studies have done on the root causes of variations, they have not been focused on proximate factors of variations that lead to disputes in Sri Lankan road projects. This study while taking a qualitative approach included a literature survey, a document review and 15 semi structured interviews with the use of three case studies on Grade 3 Road Projects administered by ICTAD Publication No. ICTAD/SBD/02, Second Edition January 2007, Standard Bidding Document for Procurement of Works. Findings were validated via three expert interviews. By analyzing data using content analysis, 16 root causes, 23 proximate causes and 10 major effects of variations were identified. Although disputes are inevitable, there are measures that can be employed to manage the disputes. The study recommends a best practice guideline with 15 approaches so as to reduce the number of variations which inter-alia include the preparation of proper documentation, reviewing of design and establishment of a proper mechanism itself for processing and evaluating variations.
Speech audibility for listeners with high-frequency hearing loss.

This study investigated whether there are limitations on the benefit of providing audible speech information to listeners with high-frequency hearing loss. In a group of 10 listeners with various degrees of high-frequency hearing loss, speech recognition was tested across a wide range of presentation levels. For each of these listeners with hearing loss, recognition performance reached an asymptote of < 100%. When the spectrum of the speech for this asymptotic performance level was compared with the listener's pure-tone thresholds, it was seen that providing audible speech to high-frequency regions (> or = 3000 Hz), where hearing loss exceeds 55 dB HL, tended to produce little or no improvement in recognition scores. In contrast, providing audible speech to lower frequency regions for a listener with a flat, severe-to-profound hearing loss did show improvement with increasing speech audibility, despite this listener's thresholds being greater than 55 dB HL. The present study adds further support to the idea that attempting to provide amplification to regions with severe high-frequency hearing loss (> or = 3000 Hz) may not necessarily benefit many individuals with hearing loss.
Tingkat Kepuasan Pasien terhadap Pelayanan Kefarmasian di RSUD Dr. Murjani Sampit

Good pharmaceutical services are directly oriented services in the drug use process aimed at ensuring the safety, effectiveness, and rationality of drug use by applying science and function in patient care. Consumer satisfaction is the response of customer or service user for each service provided. The purpose of this study was to determine the level of patient satisfaction with pharmaceutical service in RSUD Dr. Murjani Sampit. This study was conducted using the descriptive method. The level of satisfaction was measured by the five dimensions of service quality and was analyzed using percentage and Likert scale. The results showed the average percentage of interpretation score of 68% which means included in the category of satisfaction.
Implementasi Pemenuhan Hak bagi Penyandang Disabilitas Ketenagakerjaan di Semarang

Penelitian ini bertujuan untuk mengetahui tentang implementasi pemenuhan hak bagi penyandang disabilitas di bidang ketenagakerjaan di Kota Semarang berdasarkan Pasal 53 UU No. 8/2016 tentang Penyandang Disabilitas. Metode penelitian yang digunakan dalam penelitian ini adalah yuridis empiris. Hasil penelitian ditemukan bahwa Pertama, implementasi pemenuhan hak bagi penyandang disabilitas di bidang ketenagakerjaan di Semarang belum sepenuhnya berjalan sebagaimana mestinya. Kedua, terdapat beberapa faktor yang menjadikan Pemerintah Kota Semarang belum cukup dalam mengim-plementasi pemenuhan hak bagi penyandang disabilitas ketenagakerjaan di Semarang. Implementation of the Fullfilment of Rights for People with Disability in the Employment in Semarang This study aims to find out examine the implementation of the fulfillment of rights for people with disabilities in the employment field in Semarang based on Article 53 the Law Number 8 year 2016 on People with Disability. This research used empirical juridical method. The results study found that First, the implementation of the fulfillment of rights for disabilities in Semarang has not been fully implemented properly. Secondly, there are several factors that make the Government of Semarang has not properly implemented the rights for people with disabilities in Semarang.
Central venous catheterization via the external jugular vein. A technique employing the J-WIRE.

CENTRAL venous pressure (CVP) measurement provides valuable clinical data during the perioperative period. A variety of routes and techniques for obtaining CVP data have been described. Cannulation of the antecubital vein is easy, but passage of a long catheter to a central location from the antecubital site is frequently difficult and unsuccessful. Cannulation of the subclavian or internal jugular vein provides reliable and accurate CVP, but is technically demanding and has resulted in severe complications. Peripheral venous pressure measurement from the external jugular vein can accurately reflect CVP, but is position-dependent and often unreliable. Passage of a catheter into a central venous position via the external jugular vein is very difficult with present methods. This study was designed to evaluate an easy, dependable, and safe method of catheter placement in the superior vena cava via the external jugular vein, employing a flexible angiographic wire catheter guide (J-wire). Methods A pilot
Building Healthy Community Relationships Through Food Security and Food Sovereignty

Food insecurity disproportionately affects Indigenous Peoples and is linked to poor health outcomes. Indigenous Peoples’ food systems once sustained their thriving societies; however, colonial policies of displacement and imposed assimilation severed connections to Indigenous food systems and lands, disrupting identity, culture, and well-being.In this article we share a grass-roots designed program that addresses food security and heeds Haudenosaunee teachings. The Story of Creation, the Great Law, and Ohénton Karihwatéhkwen (the words that come before all else) were the basis of the framework. The program acknowledges and uses community strengths and skills to enhance social connections and links with land and creation.The program brought together interested and knowledgeable community members and stakeholders to discuss and better understand food security in the community. This group formed as an advisory group called Ieiénthos Akotióhkwa – ‘Planting Group’ who shaped the food security activities.The program delivered workshops to build skills and share knowledge about food production and preparation. It targeted diverse participant interests and needs within an environment meant to nurture social connections. The program planted food-bearing trees and plants and created a seed library to create edible landscapes. We invited a broad scope of community knowledge- and skill-holders to share their talents with the community, to reinforce positive connections with each other, and to carry on cultural practices.Challenges included program sustainability linked to short-term funding and personnel turnover. Strengths involved using a culturally based framework that enhanced program coherence, and facilitated collaboration with local initiatives focused on well-being, practicing culture, and respecting the environment. Haudenosaunee teachings hold values and principles for a society that provides food for all. These teachings are a framework for a culturally rich program to support food security skills and resources, but also Indigenous cultural identity and practices.
A trial comparing noninvasive ventilation strategies in preterm infants.

BACKGROUND To reduce the risk of bronchopulmonary dysplasia in extremely-low-birth-weight infants, clinicians attempt to minimize the use of endotracheal intubation by the early introduction of less invasive forms of positive airway pressure. METHODS We randomly assigned 1009 infants with a birth weight of less than 1000 g and a gestational age of less than 30 weeks to one of two forms of noninvasive respiratory support--nasal intermittent positive-pressure ventilation (IPPV) or nasal continuous positive airway pressure (CPAP)--at the time of the first use of noninvasive respiratory support during the first 28 days of life. The primary outcome was death before 36 weeks of postmenstrual age or survival with bronchopulmonary dysplasia. RESULTS Of the 497 infants assigned to nasal IPPV for whom adequate data were available, 191 died or survived with bronchopulmonary dysplasia (38.4%), as compared with 180 of 490 infants assigned to nasal CPAP (36.7%) (adjusted odds ratio, 1.09; 95% confidence interval, 0.83 to 1.43; P=0.56). The frequencies of air leaks and necrotizing enterocolitis, the duration of respiratory support, and the time to full feedings did not differ significantly between treatment groups. CONCLUSIONS Among extremely-low-birth-weight infants, the rate of survival to 36 weeks of postmenstrual age without bronchopulmonary dysplasia did not differ significantly after noninvasive respiratory support with nasal IPPV as compared with nasal CPAP. (Funded by the Canadian Institutes of Health Research; NIPPV ClinicalTrials.gov number, NCT00433212; Controlled-Trials.com number, ISRCTN15233270.).