Miracle-dz/UniFAR-FTUs huggingface dataset:
User satisfaction with orthotic and prosthetic devices and services of a single clinic

Purpose: To evaluate the user satisfaction with orthotic and prosthetic (O & P) devices and services of a single clinic. Method: In this survey, 293 volunteer users of a private O & P facility (172 women, 121 men) in Iran were participated. User satisfaction was evaluated with the O & P Users’ Survey. Results: For device satisfaction, the highest satisfaction was for well fitting of device (2.6 ± 0.8) and the lowest satisfaction was for the appearance of the device (1.6 ± 1.4). For service satisfaction, the highest satisfaction was for being shown an appropriate level of courtesy and respect by staff (3.3 ± 0.7), and the lowest satisfaction was for coordination between O & P staff and the users’ therapists and doctors (1.2 ± 1.3). Conclusions: Most of patients agreed that their devices were fitted well and the higher concerns were related to the appearance, durability, wear and tear of the cloths, and price of their devices. Users agreed that they were treated with a high level of courtesy and respect by O & P staff, but that the staff did not coordinate services adequately with their therapists and doctors. User participation in the decision-making process was also rated as poor. Our findings may represent valuable information which can be applied to improve O & P facilities in developing countries. Implications for Rehabilitation Evaluation of user satisfaction widely uses in variety of health care systems to show the effectiveness of the system. The current study clearly showed the strengths and weaknesses of Iranian orthotic and prosthetic therapy. Findings of the current study, represent valuable information which can be applied to improve the quality of devices and services offered by orthotic and prosthetic facilities in developing countries.
Cloning and Molecular Characterization of the Basic Peroxidase Isoenzyme from Zinnia elegans, an Enzyme Involved in Lignin Biosynthesis1[w]

The major basic peroxidase from Zinnia elegans (ZePrx) suspension cell cultures was purified and cloned, and its properties and organ expression were characterized. The ZePrx was composed of two isoforms with a Mr (determined by matrix-assisted laser-desorption ionization time of flight) of 34,700 (ZePrx34.70) and a Mr of 33,440 (ZePrx33.44). Both isoforms showed absorption maxima at 403 (Soret band), 500, and 640 nm, suggesting that both are high-spin ferric secretory class III peroxidases. Mr differences between them were due to the glycan moieties, and were confirmed from the total similarity of the N-terminal sequences (LSTTFYDTT) and by the 99.9% similarity of the tryptic fragment fingerprints obtained by reverse-phase nano-liquid chromatography. Four full-length cDNAs coding for these peroxidases were cloned. They only differ in the 5′-untranslated region. These differences probably indicate different ways in mRNA transport, stability, and regulation. According to the kcat and apparent KmRH values shown by both peroxidases for the three monolignols, sinapyl alcohol was the best substrate, the endwise polymerization of sinapyl alcohol by both ZePrxs yielding highly polymerized lignins with polymerization degrees ≥87. Western blots using anti-ZePrx34.70 IgGs showed that ZePrx33.44 was expressed in tracheary elements, roots, and hypocotyls, while ZePrx34.70 was only expressed in roots and young hypocotyls. None of the ZePrx isoforms was significantly expressed in either leaves or cotyledons. A neighbor-joining tree constructed for the four full-length cDNAs suggests that the four putative paralogous genes encoding the four cDNAs result from duplication of a previously duplicated ancestral gene, as may be deduced from the conserved nature and conserved position of the introns.
Link to Leeds Beckett Repository record:

The Extra Load Index (ELI) has been proposed as a suitable method of assessing the relative economy of load carriage systems. The purpose of this study was to determine, based on empirical evidence, that the ELI can accommodate variations in both body composition and added load. Thirty women walked carrying loads of up to 70% BM at self selected walking speeds whilst expired air was collected. In addition each of the women had body composition assessed via DXA. Results show that the ELI is independent of body composition variables, the magnitude of additional loads and the speed of progression. Consequently it is suggested that it represents an appropriate method of comparing load carriage systems in both scientific and commercial arena.
Donor origin of de novo hepatocellular carcinoma in hepatic allografts

Background. Hepatocellular carcinomas (HCC) that originate de novo in liver transplants without preceding HCC in the explanted organ have only rarely been reported. Because recent data demonstrated a mixed hepatocellular chimerism caused by the integration of host-derived stem cells, a study was conducted on the origin of tumor cells in de novo HCC. Methods. From two cases of de novo HCC arising in liver transplants after hepatitis B reinfection, tumor cells and non-neoplastic liver cells from the patient’s own liver and donor liver were isolated by laser microdissection, and highly polymorphic short tandem DNA repeats (STR) were investigated. Results. Isolated tumor cells revealed donor-specific STR genotypes that could clearly be discriminated from the genotype of the host. Conclusions. Hepatitis B virus-associated de novo HCC in liver transplants is of donor but not of host origin. The new technique described here can also discriminate between true recurrence of the original tumor and new recipient tumors.
INFORMATION COMMUNICATION TECHNOLOGIES EXPORT and ECONOMIC GROWTH RELATIONSHIP: AN ANALYSIS on SELECTED COUNTRIES

Purpose- The purpose of this study is to analyze the effects on economic growth of export in the leading countries ICT exports. In this context, the relationship between information communication technology exports and economic growth of 7 selected countries using annual data between 2000-2015 was investigated with the help of panel data analysis. Methodology- The relationship between information communication technology exports and economic growth of 7 selected countries using annual data between 2000-2015 was investigated with the help of panel data analysis. Findings- The existence of cross section dependency and the slope coefficients are homogeneous. According to the analysis of causality, there is a bi-directional causality relation from export of information technologies to economic growth. Conclusion- This result reveals the importance of information and communication technologies’ export to support economic growth. As a result of policies to be implemented in this direction, the growing sector can make a significant contribution to growth by creating production and export increases.
Shear wave elastography results correlate with liver fibrosis histology and liver function reserve.

AIM To evaluate the correlation of shear wave elastography (SWE) results with liver fibrosis histology and quantitative function reserve. METHODS Weekly subcutaneous injection of 60% carbon tetrachloride (1.5 mL/kg) was given to 12 canines for 24 wk to induce experimental liver fibrosis, with olive oil given to 2 control canines. At 24 wk, liver condition was evaluated using clinical biochemistry assays, SWE imaging, lidocaine metabolite monoethylglycine-xylidide (MEGX) test, and histologic fibrosis grading. Clinical biochemistry assays were performed at the institutional central laboratory for routine liver function evaluation. Liver stiffness was measured in triplicate from three different intercostal spaces and expressed as mean liver stiffness modulus (LSM). Plasma concentrations of lidocaine and its metabolite MEGX were determined using high-performance liquid chromatography repeated in duplicate. Liver biopsy samples were fixed in 10% formaldehyde, and liver fibrosis was graded using the modified histological activity index Knodell score (F0-F4). Correlations among histologic grading, LSM, and MEGX measures were analyzed with the Pearson linear correlation coefficient. RESULTS At 24 wk liver fibrosis histologic grading was as follows: F0, n = 2 (control); F1, n = 0; F2, n = 3; F3, n = 7; and F4, n = 2. SWE LSM was positively correlated with histologic grading (r = 0.835, P < 0.001). Specifically, the F4 group had a significantly higher elastic modulus than the F3, F2, and F0 groups (P = 0.002, P = 0.003, and P = 0.006, respectively), and the F3 group also had a significantly higher modulus than the control F0 group (P = 0.039). LSM was negatively associated with plasma MEGX concentrations at 30 min (r = -0.642; P = 0.013) and 60 min (r = -0.651; P = 0.012), time to ½ of the maximum concentration (r = -0.538; P = 0.047), and the area under the curve (r = -0.636; P = 0.014). Multiple comparisons showed identical differences in these three measures: significantly lower with F4 (P = 0.037) and F3 (P = 0.032) as compared to F0 and significantly lower with F4 as compared to F2 (P = 0.032). CONCLUSION SWE LSM shows a good correlation with histologic fibrosis grading and pharmacologic quantitative liver function reserve in experimental severe fibrosis and cirrhosis.
Stigma, Body Image, and Quality of Life in Women Seeking Orthognathic Surgery

Background: Orthognathic surgery has been increasingly performed in the authors' country. To ascertain the increased satisfaction that comes with surgery, it is necessary to evaluate the patient's motivation for surgery. Methods: Seventy-four female patients were evaluated before surgery. The control group consisted of 124 female patients. All participants completed the measures of perception of appearance, body image, stigma, and quality of life on an individual basis. These measures were tested, with satisfactory reliability and validity. Results: Patients scored significantly lower than the control group on the measures for perception of appearance, stigma of surgery, and quality of life, but higher on appearance orientation and stigma of deformity. Correlation analyses revealed various patterns of intercorrelations of subscales of stigma and body image in both groups. Regression analysis yielded three significant predictors for surgery motivation (i.e., satisfaction of facial areas, stigma of surgery, and appearance orientation), altogether accounting for 46.2 percent of the total variance. Conclusions: Given the broadly known importance of body image in seeking surgery, it may be equally important to take stigma into consideration of the patient's motivation. Further investigations are needed.
Undetectable postoperative cortisol does not always predict long‐term remission in Cushing’s disease: a single centre audit *

objective An undetectable postoperative serum cortisol has been regarded as a definition of cure in Cushing’s disease. However, we noted disease recurrence amongst patients with Cushing’s disease despite undetectable postoperative cortisol levels, and this led us to audit our data. We have also previously assessed surgical outcome for acromegaly and microprolactinoma for a single surgeon. The aims of this study were two‐fold: (i) to investigate the treatment and surgical outcome of patients with Cushing’s disease. In particular, we wished to compare the data with outcome for other pituitary tumours in our centre; and (ii) to determine whether undetectable cortisol following surgery is predictive of long‐term cure for Cushing’s disease.
Transformational Leadership in Nursing Service A Test of Theory

What are the leadership dimensions that result in low turnover or work satisfaction? Intellectual stimulation, charisma, and individual consideration constitute aspects of transformational leadership that are suggested to enhance retention and staff satisfaction. In this study, the authors tested transformational leadership theory in one nursing department with an executive, 11 midlevel administrators, and 77 staff registered nurses. Findings support the predictions. Composed of teachable components, transformational factors are similar to leadership qualities described in magnet hospitals, offering positive implications for nursing administration and professional nursing practice.
Sites That Direct Nuclear Compartmentalization Are near the 5′ End of the Mouse Immunoglobulin Heavy-Chain Locus

ABSTRACT VDJ rearrangement in the mouse immunoglobulin heavy chain (Igh) locus involves a combination of events, including a large change in its nuclear compartmentalization. Prior to rearrangement, Igh moves from its default peripheral location near the nuclear envelope to an interior compartment, and after rearrangement it returns to the periphery. To identify any sites in Igh responsible for its association with the periphery, we systematically analyzed the nuclear positions of the Igh locus in mouse non-B- and B-cell lines and, importantly, in primary splenic lipopolysaccharide-stimulated B cells and plasmablasts. We found that a broad ∼1-Mb region in the 5′ half of the variable-gene region heavy-chain (Vh) locus regularly colocalizes with the nuclear lamina. The 3′ half of the Vh gene region is less frequently colocalized with the periphery, while sequences flanking the Vh gene region are infrequently so. Importantly, in plasmacytomas, VDJ rearrangements that delete most of the Vh locus, including part of the 5′ half of the Vh gene region, result in loss of peripheral compartmentalization, while deletion of only the proximal half of the Vh gene region does not. In addition, when Igh-Myc translocations move the Vh genes to a new chromosome, the distal Vh gene region is still associated with the nuclear periphery. Thus, the Igh region that interacts with the nuclear periphery is localized but is likely comprised of multiple sites that are distributed over ∼1 Mb in the 5′ half of the Vh gene region. This 5′ Vh gene region that produces peripheral compartmentalization is the same region that is distinguished by requirements for interleukin-7, Pax5, and Ezh2 for rearrangement of the Vh genes.
E-Learning Success Model: An Extention of DeLone & McLean IS' Success Model

Learning by using e-learning system at this time become an important part of university to carrying out the education. Learning by e-learning system is very supportive to conventional learning, so it is necessary to measure the success of e-learning implementation. In this article, the research model was developed by integrating. DeLone& McLean IS concept of success model and adoption model of e-learning success. The variables that used in this research is technical system quality, service quality, content and information quality, use, user perceived satisfaction, and individual impact. Data collection is by conducting surveys to e-learning users which is lecturers and students. To test the model that has been developed, conducted a survey on UPN "Veteran" Jakarta with the total number of respondents as many as 180 respondents and obtained 157 respondents who fill the questionnaire correctly. This research, shows both the use and satisfaction of e-learning system have an impact for individual performance. This research also found that educational system quality and technical quality are the main factors that encourage user satisfaction with e-learning system, while the use of e-learning system that influenced by content & information quality, also user perceived satisfaction for e-learning system.
Self-efficacy and smoking cessation: a meta-analysis.

According to relapse models, self-efficacy (SE), or confidence in one's ability to abstain, should predict the outcome of an attempt to quit smoking. We reviewed 54 studies that prospectively examined this relationship. The relationship between SE and future smoking depended upon the population studied and the timing of the SE assessment. The relationship between SE and future smoking was modest when SE was assessed prior to a quit attempt; SE scores were . 21 standard deviation units (SD) higher for those not smoking at follow-up than for those who were smoking. The relationship was stronger (.47 SD) when SE was assessed post-quit. However, this effect was diminished when only abstainers at the time of the SE assessment were included in analysis (.28 SD). Controlling for smoking status at the time of SE assessment substantially reduced the relationship between SE and future smoking. Although SE has a reliable association with future abstinence, it is less robust than expected. Many studies may overestimate the relationship by failing to appropriately control for smoking behavior at the time of the SE assessment. (PsycINFO Database Record (c) 2009 APA, all rights reserved).
A Separate Circadian Oscillator Controls Nocturnal Migratory Restlessness in the Songbird Sylvia borin

When confined to a cage, migratory songbirds exhibit nocturnal migratory restlessness (also called Zugunruhe) during the spring and autumn migratory periods, even though these birds are exclusively diurnal during the remainder of the year. Zugunruhe, which has been demonstrated to be under the direct control of a circannual timer, is characterized by a stereotypic “wing-whirring” behavior while the bird is perched. To elucidate the role played by the circadian system in the regulation of Zugunruhe, the authors studied the activity of garden warblers (Sylvia borin), long-distance nocturnal migrants, under skeleton photoperiods of different lengths and under constant dim light. In 11.5D:1L:10.5D:1L skeleton photoperiods, the authors found that Zugunruhe free-ran in a substantial proportion of birds, while their normal daily activities (e.g., feeding and preening) remained synchronized to 24 h. Some birds expressing Zugunruhe under constant dim light continued to show 2 distinct bouts of activity: one corresponding to daily activities, the other to wing-whirring. In some cases, these 2 bouts crossed while free-running with different periods. Birds expressing Zugunruhe also had significantly longer free-running periods than birds that did not. The study data suggest that the seasonal appearance of Zugunruhe is the result of the interactions of at least 2 circadian oscillators and that it is the phase relationship of these 2 oscillators that determines when nocturnal migratory restlessness is expressed. Furthermore, these data are consistent with the previously proposed internal coincidence hypothesis as a model for the ontogeny of circannual rhythms.
Information We Collect: Surveillance and Privacy in the Implementation of Google Apps for Education

The aim of this study is to show how Google’s business model is concealed within Google Apps for Education (GAFE) as well as how such a bundle is perceived within one educational organisation, consisting of approximately 30 schools. The study consists of two parts: 1) a rhetorical analysis of Google policy documents and 2) an interview study in a Swedish educational organisation. By making an implicit demarcation between the two concepts (your) ‘data’ and (collected) ‘information’ Google can disguise the presence of a business model for online marketing and, at the same time, simulate the practices and ethics of a free public service institution. This makes it problematic for Swedish schools to implement Google Apps for Education, bearing in mind Google’s surveillance practices for making profits on pupil’s algorithmic identities. From a front end viewpoint of Google Apps for Education, the advantages of the services are evident to the users, and emerge in the study, whereas back end strategies are relatively hidden.
Interrogating a statistic: HIV prevalence rates in PNG

This discussion paper interrogates recent estimates of HIV prevalence in PNG and explores the relevance of international conceptualisations of HIV epidemics to the situation in PNG. It contributes to the quest to ‘Know your epidemic, know your response’, in particular in PNG contexts (UNAIDS 2007a: 10). The global endeavour to better ‘know your epidemic, know your response’ constitutes recognition that there are many diverse HIV epidemics and many different ways of responding to them. No single account captures their diversity. No single response keeps them at bay. Our understanding of an epidemic needs to guide us towards effective responses. So far this has not happened to any great extent. In 2007 globally some 2.5 million people became newly infected (UNAIDS 2007b: 1).
The cardiovascular and subjective effects of intravenous cocaine and morphine combinations in humans.

Intravenous cocaine (COC) and morphine (MOR) combinations ("speedballs") were administered to nine research volunteers during 12 daily experimental sessions. During each session, a single dose of MOR sulfate (0, 5 and 10 mg/70 kg) was administered i.v. in combination with a single dose of COC hydrochloride (0, 8, 16 and 32 mg/70 kg). All possible COC-MOR combinations were each tested once. Measures of subjective effects were obtained repeatedly, heart rate, diastolic and systolic blood pressure were sampled every 2 min and blood levels of COC and MOR were obtained at three time points. Both COC and MOR alone significantly increased peak heart rate, diastolic pressure and systolic pressure. The cardiovascular effects of COC were larger and longer in duration than morphine, as indicated by larger area under the curve measures compared to MOR. COC alone increased visual analog scales ratings of "stimulated" and A scores of the Addiction Research Center Inventory, whereas MOR alone increased opiate symptoms and ratings of "sedated" and both drugs increased ratings of "high. " For the most part, the cardiovascular effects of COC-MOR combinations could be predicted by the effects of COC alone, and the subjective effects of the combinations could be predicted by either drug alone. The drug combination produced increases in cardiovascular and subjective effects that were less than predicted by an effect addition model of drug interaction. The disposition of both COC and MOR was unaffected by the presence of the other drug. These results suggest that the self-administration of this drug combination may be related to a unique profile of opiate and stimulant effects instead of an alteration in the effects produced by either drug alone.
Fine Tuning and Cross-talking of TGF-β Signal by Inhibitory Smads

Transforming Growth Factor (TGF)-β family, including TGF-β, bone morphorgenic protein (BMP), and activn, plays an important role in essential cellular functions such as proliferation, differentiation, apoptosis, tissue remodeling, angiognesis, immune responses, and cell adhesions. TGF-β predominantly transmits the signals through serine/ threonine receptor kinases and cytoplasmic proteins called Smads. Since the discovery of TGF-β in the early 1980s, the dysregulation of TGF-β/Smad signaling has been implicated in the pathogenesis of human diseases. Among signal transducers in TGF-β/Smad signaling, inhibitory Smads (I-Smads), Smad6 and Smad7, act as major negative regulators forming autoinhibitory feedback loops and mediate the cross-talking with other signaling pathways. Expressions of I-Smads are mainly regulated on the transcriptional levels and post-translational protein degradations and their intracellular levels are tightly controlled to maintain the homeostatic balances. However, abnormal levels of I-Smads in the pathological conditions elicit the altered TGF-β signaling in cells, eventually causing TGF-β-related human diseases. Thus, exploring the molecular mechanisms about the regulations of ISmads may provide the therapeutic clues for human diseases induced by the abnormal TGF-β signaling.