Miracle-dz/UniFAR-FTUs huggingface dataset:
Not All Sounds Have Negative Effects on Children Undergoing Cardiac Surgery.

OBJECTIVE This study was designed to evaluate the role of music therapy on the level of stress in children undergoing repair of congenital heart disease. DESIGN Prospective, randomized, double-blind, controlled clinical trial. SETTING Children's university hospital. PARTICIPANTS Fifty children aged 4 to 12 years undergoing repair of congenital heart disease. INTERVENTIONS Patients were randomized into 2 equal groups (control group and music group); in the control group, patients listened to a blank CD, and in the music group, patients listened to a recorded CD of music and songs preferred by the child. Demographic data, clinical data, and preoperative vital signs were recorded. Baseline stress markers (blood glucose and cortisol levels) were sampled. Patients were assessed intraoperatively until extubation for vital signs and stress markers and after extubation for pain and sedation scales. An interview was conducted within the first postoperative week with the patients and their parents for assessment of post-traumatic stress disorder and negative postoperative behavior changes. MEASUREMENTS AND MAIN RESULTS There were no significant differences in demographic characteristics, clinical data, vital signs, preoperative and at-extubation blood glucose levels, and preoperative blood cortisol levels between groups. Significant differences were found between groups in blood glucose levels and cortisol levels at all intraoperative times, but only in cortisol blood levels at extubation. Significant differences were found in pain score, sedation score, occurrence of child post-traumatic stress disorder, and occurrence of negative postoperative behavior. CONCLUSION Listening to favorable music by children undergoing repair for congenital heart disease resulted in less stress and more relaxation.
Long-term follow-up CT scan evaluation in patients with pulmonary sarcoidosis.

OBJECTIVES The aim of the present study was to determine how the pattern and extent of sarcoidosis changes over time on serial high-resolution CT (HRCT) scans and to identify CT scan findings that might be helpful in predicting the prognosis of patients with the disease. METHODS The initial and last HRCT scan findings of 40 patients with pulmonary sarcoidosis during a mean follow-up period of 7.4 years (range, 3 to 18 years) were evaluated retrospectively. HRCT scan findings then were correlated with the pulmonary function tests. RESULTS Parenchymal abnormalities in most patients with a predominant nodular pattern (18 patients) and multiple large nodular pattern (8 patients) disappeared or decreased in size on long-term follow-up CT scans. A conglomeration pattern (five patients) shrank and evolved into bronchial distortion. The shrinkage of the conglomeration pattern correlated with a decline of FEV1/FVC ratio, despite an improvement in FVC. A ground-glass opacity pattern (five patients) and a consolidation pattern (three patients) evolved into honeycombing. The evolution of the ground-glass opacity and consolidation patterns into honeycombing occurred along with a decline in FVC, although the parenchymal abnormalities became smaller. CONCLUSION Patients with a predominantly ground-glass opacity pattern and consolidation pattern seen on the initial CT scan had a worse prognosis and were susceptible to developing severe respiratory insufficiency. The predominant patterns seen on the initial HRCT scan may be helpful in predicting the outcomes of patients with sarcoidosis.
Cell Division in a Species of Erwinia IX. Electron Microscopy of Normally Dividing Cells

Grula, E. A. (Oklahoma State University, Stillwater), and Gerald L. Smith. Cell division in a species of Erwinia. IX. Electron microscopy of normally dividing cells. J. Bacteriol. 90:1054–1058. 1965. —Cells of an Erwinia species (an Enterobacteriaceae) divide by concomitant invagination of the cell wall and membrane. It is concluded that the process is initiated and sustained by the cell membrane.
Theoretical investigation on heats of formation for derivatives of 1,2,4-triazole

Heats of formation (HOFs) for the derivatives of 1,2,4-triazole in gas at 298 K were determined for the first time using isodesmic reactions at B3P86/6-311G** level. The performance of employed theory level and isodesmic reactions for calculating HOFs was first verified to be accurate to within 1.6 kcal mol−1 by a test molecule system. The data of HOFs indicate that energetic materials with high positive HOFs can be obtained by introducing nitro, nitroamino group substituting at N atom.
Selective optogenetic activation of arcuate kisspeptin neurons generates pulsatile luteinizing hormone secretion

Significance The mammalian reproductive system is critically dependent upon pulsatile gonadotropin hormone release driven by a small population of gonadotropin-releasing hormone neurons in the brain. However, the mechanisms underlying the episodic activation of the gonadotropin-releasing hormone neurons to drive pulsatile hormone release are unknown. We report here that, using optogenetics in vivo, the synchronous activation of a population of kisspeptin neurons located in the hypothalamic arcuate nucleus is remarkably potent at generating pulsatile gonadotropin secretion. This system exhibits major sex differences and is modulated by the gonadal steroid environment of the organism. These results provide an important insight into the brain mechanism underlying gonadotropin pulsatility in mammalian reproductive biology. Normal reproductive functioning in mammals depends upon gonadotropin-releasing hormone (GnRH) neurons generating a pulsatile pattern of gonadotropin secretion. The neural mechanism underlying the episodic release of GnRH is not known, although recent studies have suggested that the kisspeptin neurons located in the arcuate nucleus (ARN) may be involved. In the present experiments we expressed channelrhodopsin (ChR2) in the ARN kisspeptin population to test directly whether synchronous activation of these neurons would generate pulsatile luteinizing hormone (LH) secretion in vivo. Characterization studies showed that this strategy targeted ChR2 to 70% of all ARN kisspeptin neurons and that, in vitro, these neurons were activated by 473-nm blue light with high fidelity up to 30 Hz. In vivo, the optogenetic activation of ARN kisspeptin neurons at 10 and 20 Hz evoked high amplitude, pulse-like increments in LH secretion in anesthetized male mice. Stimulation at 10 Hz for 2 min was sufficient to generate repetitive LH pulses. In diestrous female mice, only 20-Hz activation generated significant increments in LH secretion. In ovariectomized mice, 5-, 10-, and 20-Hz activation of ARN kisspeptin neurons were all found to evoke LH pulses. Part of the sex difference, but not the gonadal steroid dependence, resulted from differential pituitary sensitivity to GnRH. Experiments in kisspeptin receptor-null mice, showed that kisspeptin was the critical neuropeptide underlying the ability of ARN kisspeptin neurons to generate LH pulses. Together these data demonstrate that synchronized activation of the ARN kisspeptin neuronal population generates pulses of LH.
Cognitive impairment 18 years before clinical diagnosis of Alzheimer disease dementia

Objective: To examine the relation of performance on brief cognitive tests to development of clinically diagnosed Alzheimer disease (AD) dementia over the following 18 years in a sample of African Americans and European Americans. Methods: A composite cognitive test score based on tests of episodic memory, executive function, and global cognition was constructed in a prospective population-based sample of 2,125 participants (55% African American and 61% female) aged 65 years and older residing in 4 Chicago neighborhoods. Time before AD dementia diagnosis was categorized into 6 groups corresponding to data collection periods: 0.1–0.9, 1.0–3.9, 4.0–6.9, 7.0–9.9, 10.0–12.9, and 13.0–17.9 years. Results: Of 2,125 participants without clinical AD dementia, 442 (21%) developed clinical AD dementia over 18 years of follow-up. Lower composite cognitive test scores were associated with the development of AD dementia over the duration of the study. The magnitude of association between composite cognitive test score and development of AD dementia increased from an odds ratio of 3.39 (95% confidence interval 1.72, 6.67; p < 0.001) at 13.0–17.9 years to 9.84 (95% confidence interval 7.41, 13.06; p < 0.001) at 0.1–0.9 years, per SD increment. These associations were consistently larger among European Americans than among African Americans. Performance on individual cognitive tests of episodic memory, executive function, and global cognition also significantly predicted the development of AD dementia, with associations exhibiting a similar trend over 18 years. Conclusions: Our findings suggest that cognitive impairment may manifest in the preclinical phase of AD dementia substantially earlier than previously established.
Infusional floxuridine‐based therapy for patients with metastatic renal cell carcinoma

The treatment of patients with metastatic renal cell carcinoma (RCC) continues to pose a major clinical challenge. Previous studies have suggested that infusional floxuridine (FUDR) has antitumor efficacy and is well tolerated. To the authors knowledge the combination of infusional FUDR with biologic response modifiers (BRMs) has not been evaluated extensively in patients with metastatic RCC.
Dreams In Jungian Psychology: The use of Dreams as an Instrument For Research, Diagnosis and Treatment of Social Phobia.

BACKGROUND The significance of dreams has been explained in psychoanalysis, depth psychology and gestalt therapy. There are many guidelines in analytic psychology for dream interpretation and integration in clinical practice. The present study, based on the Jungian analytic model, incorporated dreams as an instrument for assessment of aetiology, the psychotherapy process and the outcome of treatment for social phobia within a clinical case study. METHOD This case study describes the use of dream analysis in treating a female youth with social phobia. RESULTS The present findings supported the three stage paradigm efficiency in the Jungian model for dream working within a clinical setting, i.e. written details, reassembly with amplification and assimilation. It was indicated that childhood and infantile traumatic events, psychosexual development malfunctions, and inefficient coping skills for solving current life events were expressed in the patient's dreams. CONCLUSION Dreams can reflect a patient's aetiology, needs, illness prognosis and psychotherapy outcome. Dreams are an instrument for the diagnosis, research and treatment of mental disturbances in a clinical setting.
Cross-Cultural Adaptation of an Intimate Partner Violence Questionnaire

The aim of this study was to describe the translation and the cross-cultural adaptation process of questionnaire about intimate partner violence (IPV). IPV is a serious threat to women’s health. There is a need for instruments to measure the results of educational interventions. The Violence Against Women Health Care Provider Survey was found suitable for translation and adaptation to the Swedish cultural context. A five-step process according to Guillemin et al. was followed: (a) translation by independent translators, (b) back translation of each translation independently from each other, (c) committee review with multidisciplinary members produces the final version, and (d) pretesting to ensure equivalence between source and final version, and (e) weighting scores. The Swedish version consisted of the same number of items as the original. The results indicated that the questionnaire can be used in Sweden to measure the effectiveness of IPV training programs.
Predicting the Onset of Emotional Recovery Following Nonmarital Relationship Dissolution: Survival Analyses of Sadness and Anger

Event onset modeling was used to investigate the time course of breakup-related affective processes. Daily emotion data were collected for 4 weeks from 58 young adults who recently experienced the dissolution of a serious romantic relationship. Using baseline data obtained from individuals in intact dating relationships, sadness and anger recovery were defined as points in time and then modeled as a function of theoretically relevant predictors using Cox’s survival analysis. Acceptance of relationship termination mediated the association between attachment security and sadness recovery. Greater levels of love, anger, and attachment preoccupation were associated with a decreased probability of sadness recovery during the study period. Attachment security was associated with an increased probability of anger recovery, whereas ongoing sadness decreased the probability of this event. Discussion centers on the differential functioning of sadness and anger as well as the need to consider emotional change as a multicomponent process.
Solitary fibrous tumors of the pleura

Purpose of review Solitary fibrous tumor of the pleura (SFTP) is a rare neoplasm of the pleura. Although an increasing number of case series have been reported in recent years, so far clinical behavior is still unpredictable. The following article presents a detailed review of the recent larger series of SFTP with particular attention to the clinical presentation, pathologic characteristics and surgical features in order to define more precisely the long-term outcome after treatment of this rare entity. Recent findings Usually, after a complete surgical resection a very long survival could be expected in almost all cases. However, the preoperative detection and management of malignant SFTPs are still challenging issues. Summary SFTP remains an enigmatic tumor. Clinical and radiological assessment is often unsatisfactory to obtain a definitive diagnosis. Benign SFTPs are almost always cured with complete surgical resection, and in cases of recurrence the re-do resection of benign recurrences is usually curative. Long-term survivals are also possible for malignant SFTPs, although a higher recurrence rate and higher tumor-related mortality can be expected in these cases. Histologic characteristics distinguishing benign from malignant variants are crucial in estimating the risk of recurrence and planning adjuvant therapies.
Reports of Head Injury and Symptom Knowledge Among College Athletes: Implications for Assessment and Educational Intervention

ObjectiveTo identify the prevalence of head injuries and related symptoms among college athletes and examine knowledge of head injury consequences and behavioral tendencies of athletes in the presence of symptoms. DesignRetrospective survey. ParticipantsA total of 461 male and female athletes beginning competitive play at the University of Akron (Akron, OH) during the years 1995 to 2001. Main Outcome MeasuresResponses to survey questions were analyzed to determine the frequency of concussions and injury-related symptoms (eg, dizziness, headache, nausea or vomiting) in addition to behavioral responses in the presence of certain symptoms (eg, playing with headache, failure to report symptoms while playing). Written responses to queries regarding symptom knowledge were analyzed for thematic content and were used to identify deficiencies in signs and symptoms of concussion. ResultsNearly 32% of all athletes had experienced a blow to the head causing dizziness, with over 1/4 confirming various somatic symptoms following a blow to the head (eg, seeing stars, nausea or vomiting, head pain). Continuing to play despite symptom presence was noted (eg, dizziness, 28.2%; headache, 30.4%), with 19.5% reporting a concussion diagnosis. Knowledge of head injury consequences was found to be deficient, with 56% indicating no knowledge of the possible consequences following a head injury. Of those providing responses, the majority reflected awareness of cognitive (eg, memory problems) and physical (eg, brain damage) consequences. ConclusionsA sizable number of athletes may enter collegiate play with a previous concussion diagnosis, and many more are likely to have experienced symptoms suggestive of a mild head injury. Of considerable concern is the tendency to play while symptomatic (eg, headache, dizziness) and the failure to report symptoms while playing—especially among football players (25.2%). The apparent deficiency in athlete knowledge of head injury consequences raises concern regarding athlete recognition of potentially problematic symptoms and represents an important area for educational intervention.
Performance Evaluation of an Agro Waste Based Biofilter Treating Toluene Vapours

Biodegradation of toluene vapour was investigated for 162 days in a laboratory scale biofilter packed with maize waste. Inlet concentration of toluene was varied from 2.86 to 5.79 g m−3 and the volumetric flow rate of toluene loaded air from 0.09 to 0.3 m3h−1. The media bed height used in the study was 0.63 m. Plug flow behaviour of the bed was confirmed by RTD experiments. The steady state was achieved in 18 days. Depending upon initial loading rates, removal efficiency ranging from 54.5 to 85.3 % and elimination capacity ranging from 43.47 to 174.6 g h−1m−3 were observed during steady state operation. The dynamic behaviour of the biofilter was evident from response to change in process conditions. The stability of the biomass was evident from the fast response of the biofilter to shutdown and restart operations. High value of carbon recovery confirms the effective biodegradation in the biofilter. In the startup period, the pressure drop in the bed increased for some time after that it tended towards a constant value.
Human oocyte cryopreservation as an adjunct to IVF-embryo transfer cycles.

BACKGROUND The purpose of this work was to develop methods for successful cryopreservation of human oocytes. METHODS Two cryopreservation procedures were used. Method 1 involved use of 1.5 mol/l propanediol (PrOH)-0.1 mol/l sucrose with medium containing sodium (Na) as cryoprotectant medium, seeding at -7 degrees C, and stepwise dilution of cryoprotectant post-thaw. Method 2 used Na-depleted media with 1.5 mol/l PrOH-0.2 mol/l sucrose for freezing, seeding at -6 degrees C, and use of high sucrose (0.5 and 0.2 mol/l) for cryoprotectant removal. RESULTS The first method was used in seven patients, and gave poor (12.3%) survival results and no pregnancies. The second method was used in 15 patients (16 cycles), and yielded good survival and fertilization rates (74.4 and 59% respectively), with four pregnancies and five healthy infants born to 11 women receiving an embryo transfer. CONCLUSIONS Using Na-depleted media along with other alterations in freezing and thawing procedures, human oocyte cryopreservation can provide excellent survival and pregnancy rates.
GABA and Its Agonists Improved Visual Cortical Function in Senescent Monkeys

Human cerebral cortical function degrades during old age. Much of this change may result from a degradation of intracortical inhibition during senescence. We used multibarreled microelectrodes to study the effects of electrophoretic application of γ-aminobutyric acid (GABA), the GABA type a (GABAa) receptor agonist muscimol, and the GABAa receptor antagonist bicuculline, respectively, on the properties of individual V1 cells in old monkeys. Bicuculline exerted a much weaker effect on neuronal responses in old than in young animals, confirming a degradation of GABA-mediated inhibition. On the other hand, the administration of GABA and muscimol resulted in improved visual function. Many treated cells in area V1 of old animals displayed responses typical of young cells. The present results have important implications for the treatment of the sensory, motor, and cognitive declines that accompany old age.
Invariant Domains Preserving Arbitrary Lagrangian Eulerian Approximation of Hyperbolic Systems with Continuous Finite Elements

A conservative invariant domain preserving arbitrary Lagrangian Eulerian method for solving nonlinear hyperbolic systems is introduced. The method is explicit in time, works with continuous finite elements, and is first-order accurate in space. One original element of the present work is that the artificial viscosity is unambiguously defined irrespective of the mesh geometry/anisotropy and does not depend on any ad hoc parameter. The proposed method is meant to be a stepping stone for the construction of higher-order methods in space by using appropriate limitation techniques.
Delayed Chemotherapy-induced Nausea and Vomiting in Autologous Hematopoietic Cell Transplant Patients: An Exploratory Analysis

Purpose Delayed chemotherapy-induced nausea and vomiting (CINV) continues to be a problem in patients undergoing a hematopoietic cell transplant (HCT) despite progress in antiemetic prophylaxis. This study investigated the clinical course of nausea and vomiting (NV) and retching over the 5 days following an autologous HCT in a transplant setting. Methods This longitudinal observational study was an exploratory analysis of data from a trial that assessed the efficacy of aroma in preventing NV related to dimethyl sulfoxide in 69 autologous HCT patients undergoing highly emetogenic chemotherapy (HEC; n = 56) or moderately emetogenic chemotherapy (MEC; n = 13). Results Nausea started to increase on the second day after reinfusion, with a peak between 72 and 96 hours, and decreased on the fifth day. The pattern for vomiting was similar, while retching episodes remained unchanged after the third day following transplant. Nausea and emesis were observed in 73% (n = 41) and 64% (n = 36) of HEC patients, respectively, and in 85% (n = 11) and 62% (n = 8) of MEC patients, respectively. Conclusions Uncontrolled delayed CINV is still a challenge for autologous HCT patients. Nausea, vomiting and retching are 3 different symptoms that should be assessed and managed separately in routine clinical practice.
Effects of Polysaccharide Fucoidin on Cerebrospinal Fluid Interleukin-1 and Tumor Necrosis Factor Alpha in Pneumococcal Meningitis in the Rabbit

ABSTRACT The inflammatory response in bacterial meningitis is mediated by cytokines, such as tumor necrosis factor alpha (TNF-α) and interleukin-1 (IL-1), which are produced in the subarachnoid space by different cells, e.g., leukocytes, astrocytes, and microglia. The recruitment of leukocytes into the cerebrospinal fluid (CSF) has been shown to contribute to the neurological damage in this disease, a process which could be enhanced by treatment with antibiotics. In this study, we have used a rabbit meningitis model for two sets of experiments with intracisternal (i.c.) injections ofStreptococcus pneumoniae. First, pneumococcal cell wall (PCW) components were injected i.c. , inducing an inflammatory response with pleocytosis and increased levels of CSF TNF-α) and IL-1 at 6 and 12 h after PCW injection. Treatment with fucoidin, known to inhibit leukocyte rolling, abolished pleocytosis and inhibited the release of TNF-α and IL-1. In the second experiment, live pneumococcal bacteria were injected i.c. and treatment with one dose of ampicillin (40 mg/kg of body weight intravenously) was given 16 h after induction of meningitis, causing a sevenfold increase in CSF leukocytes over a 4-h period. CSF IL-1 levels at 16 h were high but did not increase further at 20 h. Also, CSF TNF-α levels were high at 16 h and tended to increase at 20 h. Fucoidin treatment prevented the antibiotic-induced increase of CSF leukocytes but had no effect on the TNF-α and IL-1 levels. Taken together, fucoidin reduced CSF TNF-α and IL-1 levels in acute bacterial meningitis induced by PCW fragments but had no effect later in the course of the disease, when live bacteria were used and an inflammatory increase was caused by a dose of antibiotics.