Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of Interleukin‐6 in Stress Response in Normal and Tumorous Adrenal Cells and during Chronic Inflammation

Abstract: Interleukin‐6 (IL‐6) is the end‐product of a cytokine signaling cascade and is secreted by specialized immune cells during inflammation. It has a great influence on many functions, including differentiation, stimulation, and activation of immune cells, or other cells of neuroendocrine origin. Thus, IL‐6 serves as a key messenger in its communication with the neuroendocrine system, and serves as a potent activator of the hypothalamic‐pituitary‐adrenal axis at all levels. Changes in the levels of expression of this cytokine and its receptor have been observed during chronic inflammatory disease, and have been associated with tumorigenesis. Therefore, we studied the effect of IL‐6 on normal and adenomatous human adrenal cells in vitro. The expression of IL‐6 receptor mRNA was quantified within the same tissue. IL‐6 potently stimulated cortisol secretion from dispersed normal human adrenal cells. We found immunoreactivity for the IL‐6 receptor on cultured cells and paraffin‐embedded sections of adrenal tissues. Further, there was a more pronounced expression of IL‐6 mRNA in adrenal adenomas of patients with Cushing's syndrome, compared to normal human adrenals. Despite this fact, the sensitivity of cells of adenomatous adrenal glands to IL‐6 was significantly decreased relative to cells from normal controls. These results were confirmed employing the permanent adrenocortical cancer cell line model NCI‐H295. We infer that the loss of responsivity of tumorous adrenal cells to IL‐6, and in part corticotropin, is an important step in the process of adrenal tumorigenesis by which regulation by differentiating proteins is bypassed.
Efficacy of Pentax airway scope versus Macintosh laryngoscope when used by novice personnel: A prospective randomized controlled study

Objective To determine whether intubation education using the Pentax Airway Scope (AWS) in normal airways is more useful than direct laryngoscopy (Macintosh laryngoscope) in novice personnel. Methods Eleven intern doctors without intubation experience performed 60 sequential intubations with each device on a manikin and 10 sequential intubations in adult patients. The time required for successful intubation, percentage of glottic opening (POGO) score, number of intubation attempts, and number of dental injuries were analyzed for each intubation technique. Results The mean (standard deviation) time required for successful intubation decreased as the number of intubations increased and was significantly shorter with the Pentax AWS than direct laryngoscope [22.6 (7.3) vs. 29.6 (10.0) and 33.0 (8.0) vs. 44.7 (5.6) s, respectively] in both the manikin and clinical studies. The Pentax AWS was also associated with higher POGO scores than the direct laryngoscope [81.7 (8.9) vs. 55.1 (13.2) and 80.9 (9.7) vs. 49.6 (16.5), respectively] and fewer intubation attempts. Fewer dental injuries occurred with the Pentax AWS in the manikin study. Conclusions Novices performed intubation more rapidly and easily with an improved laryngeal view using the Pentax AWS. We suggest that intubation education with video laryngoscopy should be mandatory along with direct laryngoscope training.
Penerapan Digital Marketing sebagai Strategi Komunikasi Pemasaran Terpadu produk Usaha Kecil dan Menengah (UKM) Pahlawan Ekonomi Surabaya

Tren pemasaran beralih dari konvensional (offline) menjadi digital (online). Konsep digital marketing bagi para pelaku usaha yaitu dapat memasarkan produknya dari mana saja dan kapan saja melalui internet. Fokus masalah yang diangkat, yaitu : (1) bagaimana strategi komunikasi pemasaran melalui digital marketing yang dilakukan oleh pelaku usaha kecil dan menengah (UKM) Pahlawan Ekonomi Surabaya dalam memasarkan produknya (2) bagaimana kendala dan manfaat penerapan digital marketing bagi pelaku usaha kecil dan menengah (UKM) Pahlawan Ekonomi Surabaya. Untuk mengungkapkan persoalan tersebut penelitian ini menggunakan jenis penelitian kualitatif yang berguna untuk memberikan fakta dan data mengenai penerapan digital marketing produk Usaha Kecil dan Menengah (UKM) Pahlawan Ekonomi Surabaya kemudian data tersebut dianalisis dengan pendekatan grounded theory yang memberikan pengembangan terhadap bidang kajian penelitian. Kemudian teknik pengumpulan data menggunakan teknik wawancara, dokumentasi, dan observasi. Teknik analisis data dengan reduksi data, penyajian data dan penarikan kesimpulan. Sedangkan teori yang digunakan dalam penelitian ini adalah teori komunikasi pemasaran terpadu. Dari hasil penelitian ditemukan bahwa strategi komunikasi melalui digital marketing kedua pelaku usaha yaitu penyampaian positioning statement di setiap postingan Facebook dan Instagram serta menjalin hubungan dengan pelanggan secara fast respond (cepat tanggap) di media sosial. Kendala dan manfaat penerapan digital marketing berkaitan dengan bauran pemasaran—4P (product, price, place, dan promotion). Saran bagi pelaku usaha yakni tetap menjalankan aktivitas pemasaran, baik konvensional maupun digital dengan konsisten, terutama mengenai digital marketing bisa dikembangkan lagi dalam pengelolaannya, karena selama ini masih dimanajemen sendiri oleh masing-masing pelaku usaha.
Variability in Platelet-Derived Growth Factor Receptor Alpha Antibody Specificity May Impact Clinical Utility of Immunohistochemistry Assays

Aberrant regulation of the receptor tyrosine kinase platelet-derived growth factor alpha (PDGFRα) is implicated in several types of cancer. Inhibition of the PDGFRα pathway may be a beneficial therapy, and detection of PDGFRα in tumor biopsies may lead to insights about which patients respond to therapy. Exploratory or clinical biomarker use of PDGFRα IHC has been frequently reported, often with polyclonal antibody sc-338. An sc-338-based assay was systematically compared with anti-PDGFRα rabbit monoclonal antibody D13C6 using immunoblot profiling and IHC in formalin-fixed and paraffin-embedded human tumor cell lines. Application of sc-338 to blots of whole cell lysates showed multiple bands including some of unknown origin, whereas application of D13C6 resulted in a prominent band at the expected molecular mass of PDGFRα. The IHC assay using D13C6 showed appropriate staining in cell lines, whereas the assay using sc-338 suggested nonspecific detection of proteins. An optimized IHC assay using D13C6 showed a range of staining in the tumor stromal compartment in lung and ovarian carcinomas. These observations suggest that use of clone sc-338 produced unreliable results and should not be used for an IHC research grade assay. In addition, this precludes its use as a potential antibody for a clinical diagnostic tool.
Employee perceptions of service quality based on hospital quality improvement strategy

Following reforms in the Taiwanese healthcare system, hospitals are facing an increasingly competitive healthcare market. Hospital administrators, in response to this competition, are placing increasing importance on improving the quality of healthcare in order to ensure patient satisfaction. How can service quality (SQ) be improved in healthcare settings? This study explored how total quality management (TQM) influences employee perceptions of SQ. A cross-sectional study was performed, for which a sample was drawn from five regional hospitals in central Taiwan. This study used questionnaires to investigate employee perceptions of TQM and SQ in five regional teaching hospitals in Central Taiwan. A total of 300 questionnaires were distributed, of which 226 valid questionnaires were returned. The findings of this study revealed that TQM influenced employee perceptions of SQ. Therefore, hospital managers should use TQM strategy to influence employee perceptions of SQ. When promoting a TQM strategy, hospital managers should develop a clear vision for quality management within their organizations combined with distinct quality improvement policies and initiatives.
Analysis of Accounting Information System Using Hot Fit Model Method in Indonesia Islamic Micro Financial Institutions

Financial institutions need to provide technology-based services that facilitate access to information for communities in remote areas. This research aims first, reviewing the use of mobile banking in improving the quality of reporting and expanding the reach of financial services; second, the practice of utilizing mobile banking for Islamic microfinance institutions in Indonesia; third, evaluating the implementation of the Islamic microfinance information system in Indonesia. The research method used in this study is descriptive quantitative, with a sample of 100 accountants. Descriptive analysis was aided by SPSS 21.0 software for Windows. The results of this study indicate that; first, Mobile banking is the right mechanism to improve the quality of reporting and make the services of Islamic microfinance institutions accessible to the poor in remote areas of Indonesia. Second, the practice of utilizing accounting information systems in Islamic microfinance institutions is already good. Third, Overall, the application of accounting information systems at Islamic microfinance institutions in Indonesia can have a positive effect on improving the services of Islamic microfinance institutions both individually accountants and organizations.
Reduced Oral Bioavailability and Altered Pharmacokinetics of Saquinavir by Co-administration with Biochanin A in Rats

Abstract The study was aim to assess the impact of biochanin A on the oral bioavailability and pharmacokinetics (PK) of saquinavir (SQV), a substrate of P-glycoprotein (P-gp), in rats. 10 male rats were randomized into 2 groups of equal size, and administered orally 30 mg/kg SQV with or without 20 mg/kg biochanin A. The PK of SQV was assessed using non-compartmental analysis. Results revealed that the area under the plasma concentration-time curve of SQV from time zero to time infinity (AUC0-∞) was reduced by 51.39% by biochanin A (P=0.038); while the apparent systemic clearance (CL/F) was increased by 87.62% (P=0.028). Double peak phenomenon was observed in the plasma SQV profiles. Biochanin A increased the first peak, yet decreased the second peak of plasma SQV levels. Our study demonstrates that biochanin A can significantly reduce SQV oral bioavailability and alter SQV PK profiles in rats. Findings in this study suggest a precaution in the clinic when SQV is administered with dietary/herbal supplements that contain biochanin A.
Optical and Structural Properties of SnO2-Based Sol-Gel Thin Films

SnO2 thin films have been deposited on glass from Sn (II)-2-ethylhexanoate precursor using the dip-coating sol-gel method. Based on spectroscopic ellipsometry (SE) measurements optical and structural properties of the SnO2 films have been obtained. It was found that the concentration of tin oxide sols used for deposition strongly influences the thickness and the optical properties of the film, such as optical constants (n and k) or optical conductivity (sigma)
INCIDENCE ETIOLOGY AND TREATMENT OF ALVEOLAR OSTEITIS 1

Alveolar osteitis is the most common post operative sequel to tooth extraction. It occurs despite the most exacting operative technique, aseptic procedure and regardless of the ability of surgeons. Various packing materials are available for topical treatment of alveolar osteitis. Purpose: The present study was conducted to evaluate and compare the effectiveness of Zinc Oxide Eugenol dressing, alvogyl dressing and platelet rich fibrin dressing in the treatment of dry socket. Materials: This study comprised 60 patients of dry socket in the span of 5 years. The patients were randomly divided into three groups on the basis of treatments: Group A (zinc oxide eugenol group), Group B (alvogyl group), and Group C (platelet rich fibrin group). The clinical progress was noted at 1 and 7 day of treatment. Results: Socket healing was faster and better in group C than in group A and B but symptomatic pain relief was faster in group A and group B. Conclusion: According to this study PRF might be a superior treatment of choice in the management of dry socket.
Genomic cloning and complete sequence analysis of a highly divergent African human immunodeficiency virus isolate

Analysis of the complete sequence of a human immunodeficiency virus (HIV) isolate (Ant70) obtained from a Cameroonian patient indicates that this virus is the most divergent strain within the HIV-1 family hitherto described. Comparison of the Pol protein, usually highly conserved within the HIV-1 family, shows only about 73% similarity with the HIVmm isolate, whereas for the more variable proteins such as envelope, similarities of 50% or lower are found. The principal neutralizing determinant (V3 loop) and the immunodominant region within gp41 also contain some unusual substitutions, which may have implications for protein function as well as for serological assays based on these regions. Phylogenetic analyses show that this isolate occupies a unique position relative to the human HIV-1 isolates and the recently described SIVcpz virus, indicating that this Cameroonian isolate may provide us with new insights into the origins of the HIV-1 family.
Upper-Body Strength Measures and Pop-Up Performance of Stronger and Weaker Surfers.

The primary purpose of this study was to investigate the reliability of the isometric push-up (IPU), dynamic push-up (DPU), and force plate pop-up (FP POP) as measures of upper-body isometric and dynamic strength qualities in surfing athletes. Furthermore, the study aimed to compare pop-up performance between stronger and weaker surfers. Eighteen female (n=9) and male (n=9) surfers (age=28.1±6.4 yrs, mass=69.6±10.4 kg, height=172.5±6.7 cm) completed a battery of upper-body strength assessments, of which exhibited high between-day reliability: (IPU, (CV%=4.7, ICC=0.96), DPU (CV%=5.0, ICC=0.90), FP POP (CV%=4.4, ICC=0.90). Participants were subsequently split into stronger (n=9) and weaker (n=9) surfers based on normalized peak force (PF) attained in the IPU. Pop-up performance was measured both in the water and during the FP POP, and was referred to as time to pop (TTP). Significant between group differences were observed for normalized PF during IPU (d=1.59, p<0.01) and DPU (d=0.94 p=0.04). Although not significant, there was a large magnitude difference in FP POP (d=0.80, p=0.08) and FP TTP (d=0.85, p=0.07). Significant correlations were identified between normalized IPU PF and normalized DPU FP (r=0.69, p=0.03) and FP TTP (r=0.73, p=0.02) in the stronger group. The weaker group exhibited a significant inverse correlation between normalized IPU PF and in water TTP (r=-0.77, p<0.01). The results suggest improvements in pop-up performance may be elicited by improving dynamic strength for stronger surfers, whereas pop-up performance in weaker surfers may be elicited by improving maximum strength. The upper-body strength assessments provided a novel insight into strength qualities that are associated with in water performance of surfers (TTP).
An exploratory study of Internet of Things (IoT) adoption intention in logistics and supply chain management - a mixed research approach

Purpose The Internet of Things (IoT) envisions a global infrastructure of networked physical objects that render radical transparency to supply chain management. Despite the perceived advantages of IoT, industry has still not widely adopted IoT-enabled logistics and supply chain management. The purpose of this paper is to understand the incentives and concerns behind firms’ decisions to adopt IoT, explore the determinant factors affecting IoT adoption in logistics and supply chain management. Design/methodology/approach This study uses mixed methods research to explore the determinants of IoT adoption intention in logistics and supply chain management. Qualitative analysis using the Grounded Theory methodology reveals the underlying perceptions regarding logistic innovation with IoT. Quantitative hypotheses are then developed based on qualitative investigation and adoption literature. Survey data were collected from the managerial staff of Taiwanese firms across various industries. Structural equation modeling with partial least square is used for data analysis. Findings The results of the qualitative study identify uncertainties and issues regarding firms’ intention to accept or reject IoT technology in logistics and supply chain management, including the benefit and cost aspects of adopting IoT, uncertainties about the trustworthiness of IoT technology, and the external motivating force to embrace IoT. The resulting quantitative model shows that perceived benefits, perceived costs, and external pressure are significant determinants of IoT adoption intention, while technology trust is not. However, technology trust does indirectly influence IoT adoption intention through perceived benefits. Practical implications The empirical findings of this study provide some guidelines for logistics and supply chain managers to evaluate IoT adoption in their firms. Likewise, IoT solution providers can also benefit from this study by improving their solutions to mitigate the IoT adoption concerns addressed herein. Originality/value This paper is among the first known to examine IoT adoption intention in logistics and supply chain management using mixed methods research. The mixed methods approach offers a better insight in understanding incentives behind firms’ decisions to adopt IoT vs the use of either a qualitative or quantitative method alone.
Automation of glucose measurement using ortho-toluidine reagent: comparison of values determined by automated ferricyanide and ortho-toluidine methods.

The measurement of plasma or serum glucose with ortho-toluidine reagent [ortho-toluidine (6% v/v) in concentrated glacial acetic acid, stabilized with thiourea (0.15% w/v)] has been automated using Technicon Corporation's AutoAnalyzer equipment. The extreme sensitivity of this reagent permitted a large reagent-to-sample volume ratio (22.5:1) which effectively eliminated assay interference by protein. Removal of protein by precipitation or by in-line dialysis or correction of results for a “sample blank” was, therefore, unnecessary. Optimal speed, precision, and accuracy were defined and assay results compared with results from standard technics. For 202 random plasma specimens, glucose values determined by the automated ortho-toluidine procedure averaged 10 mg. per 100 ml. less than values determined simultaneously by the automated alkaline ferricyanide procedure. Oral glucose tolerance test plasma specimens showed an analogous bias which appeared to be more strongly influenced by absolute glucose concentration or elapsed time since dosage. For 42 random plasma specimens the automated ortho-toluidine values averaged 3% lower, manual ortho-toluidine values averaged 1.5% lower, and automated ferricyanide values averaged 7% higher than glucose values determined enzymatically by hexokinase-glucose-6-phosphate dehydrogenase. The automated ortho-toluidine procedure approaches the ferricyanide procedure in economy, approaches the enzymatic methods in specificity, and exceeds both methods in convenience and reliability because of the minimal number of steps involved in the assay procedure.
Can green human resource management attract young talent? An empirical analysis

Purpose The purpose of this paper is to examine the effect of perceived green human resource management (GHRM) on job pursuit intention (JPI) of prospective employees. In addition, an attempt was made to unfurl the underlying psychological mechanisms and illuminate the boundary conditions of the aforementioned relationship by proposing organizational prestige (OP) as mediator and environmental orientation (EO) and gender as moderators. Design/methodology/approach In total, 172 undergraduate engineering students of a reputed engineering institute in India constituted the sample for this scenario-based study. Direct, mediation, moderation and moderated mediation hypotheses were tested using hierarchical linear regression analysis and bootstrapping procedures in SPSS. Findings GHRM was found to relate significantly with JPI of prospective applicants and OP mediated the above linkage. EO was found to significantly moderate the association of GHRM with JPI. However, gender failed to add to the understanding of the above relationship. Practical implications By providing evidence on the psychological processes which the applicants engage in during employer selection, organizations will be able to form appropriate strategies for attracting talent to their organizations. Originality/value The study addresses the call for research to integrate the diverse disciplines of environmental management and human resource management and provides additional insights into human aspect of environmental sustainability. It advances the sustainable HRM literature by providing comprehensive understanding of how and when GHRM influences prospective employee outcomes.
Cardiovascular Risks of Dipping Status and Chronic Kidney Disease in Elderly Japanese Hypertensive Patients

Chronic kidney disease (CKD) increases the risk of cardiovascular events and is often associated with the nondipping pattern of blood pressure (BP). We evaluated ambulatory BP, CKD, and the incidence of cardiovascular events in 811 older hypertensive patients. CKD and the dipping pattern increased the risk of cardiovascular events independent of the 24‐hour systolic BP level (CKD: hazard ratio [HR], 2.37; 95% confidence interval [CI], 1.24–4.54; nondippers: HR, 2.16; 95% CI, 1.19–3.91; extreme dippers: HR, 2.38; 95% CI, 1.17–4.83). However, after adjustment for covariates that included CKD, the risk in nondippers was insignificant (HR, 1.83; 95% CI, 0.998–3.34; P=.051), while the risk in extreme dippers remained (HR, 2.59; 95% CI, 1.26–5.32; P=.009) (CKD: HR, 1.81; 95% CI, 0.93–3.54; P=.081). Patients with CKD have an increased risk of cardiovascular events. CKD and other cardiovascular risk factors may account for some of the increased risk in nondippers, but it does not explain the higher risk in extreme dippers.
Human papillomavirus in sinonasal papillomas and squamous cell carcinoma

The diagnostic and prognostic relevance of human papillomavirus (HPV) types 6, 11, 16, and 18 in squamous papilloma, inverted papilloma, and squamous carcinoma of the sinonasal epithelium was examined using the polymerase chain reaction (PCR) technique. Four (15%) of 26 squamous papillomas, 7 (24%) of 29 inverted papillomas, and 1 (4%) of 24 squamous carcinomas were positive for HPV when examined using the PCR amplification technique.
Health and voice quality in smokers: An exploratory investigation

Thirty-two adults (20 smokers and 12 non-smokers) were examined to determine the effects of cigarette smoking on health (diseases and larynx histology), on fundamental frequency (regularity and jitter) and stress level. The examination consisted of nasovideostroboscopy analysis, history case, electrolaryngography assessment for different task performance and self-assessment of stress. Although not statistically different, results indicate that smokers in comparison to non-smokers show: 1) slightly more health problems; 2) histological larynx changes; 3) a higher level of stress; 4) a lower mean F0 for all speech tasks. A statistically significant difference for percentage jitter was found according to voice status for: 1) vowel [a] (the group with voice problems show higher levels of jitter than both groups without voice problems); 2) vowel [i] (the smokers with voice problems show higher levels of jitter than the smokers without voice problems).