Miracle-dz/UniFAR-FTUs huggingface dataset:
Randomized Crossover Trial of the Impact of Morning or Evening Dosing of Antihypertensive Agents on 24-Hour Ambulatory Blood Pressure: The HARMONY Trial

Some data suggest that nocturnal dosing of antihypertensive agents may reduce cardiovascular outcomes more than daytime dosing. This trial was designed to evaluate whether ambulatory blood pressure monitoring levels differ by timing of drug dosing. Patients aged 18 to 80 years with reasonably controlled hypertension (⩽150/⩽90 mm Hg) on stable therapy of ≥1 antihypertensive agent were recruited from 2 centers in London and Thessaloniki. Patients were randomized to receive usual therapy either in the morning (6 AM–11 AM) or evening (6 PM–11 PM) for 12 weeks when participants crossed over to the alternative timing for a further 12 weeks. Clinic blood pressures and a 24-hour recording were taken at baseline, 12, and 24 weeks and routine blood tests were taken at baseline. The study had 80% power to detect 3 mm Hg difference in mean 24-hour systolic blood pressure (&agr;=0.05) by time of dosing. A 2-level hierarchical regression model adjusted for center, period, and sequence was used. Of 103 recruited patients (mean age, 62; 44% female), 95 patients (92%) completed all three 24-hour recordings. Mean 24-hour systolic and diastolic blood pressures did not differ between daytime and evening dosing. Similarly, morning and evening dosing had no differential impact on mean daytime (7 AM–10 PM) and nighttime (10 PM–7 AM) blood pressure levels nor on clinic levels. Stratification by age (⩽65/≥65 years) or sex did not affect results. In summary, among hypertensive patients with reasonably well-controlled blood pressure, the timing of antihypertensive drug administration (morning or evening) did not affect mean 24-hour or clinic blood pressure levels. Clinical Trial Registration— URL: http://www.clinicaltrials. gov. Unique identifier: NCT01669928.
A Biosignal Based Driving Experience Analysis for Curved Road: An Initial Implementation*

This study presents a biosignal based driving experience analysis of an actual-vehicle experiment. A total of 10 subjects were enrolled during the experimental study. Based on their driving mileages per year, subjects were divided into novice and skilled ones at first, and then electromyography (EMG) signals of upper trapezius and sternocleidomastoid muscles were acquired continuously to evaluate a subject response to dynamic motions of the vehicle during the curve, with a driving speed of 30, 40 and 50 km/h respectively. Meanwhile, an EMG evaluation index of a normalized root mean square (RMS) was proposed to reflect the variance of EMG signals. From the experimental results, the RMS based evaluation of right upper trapezius muscle were significantly different between novice and skilled drivers, while driving with a higher speed on curve road. In addition, the RMS based evaluation of right sternocleidomastoid muscle were significantly different between novice and skilled drivers, while driving with a higher or a lower speed on curved road. It indicate that the skilled driver may have a better driving experience than that of novice ones for most curve driving conditions.
Diurnal Variation of Short-Term Repetitive Maximal Performance and Psychological Variables in Elite Judo Athletes

Objectives: The aim of this study was to examine the effect of time of day on short-term repetitive maximal performance and psychological variables in elite judo athletes. Methods: Fourteen Tunisian elite male judokas (age: 21 ± 1 years, height:172 ± 7 cm, body-mass: 70.0 ± 8.1 kg) performed a repeated shuttle sprint and jump ability (RSSJA) test (6 m × 2 m × 12.5 m every 25-s incorporating one countermovement jump (CMJ) between sprints) in the morning (7:00 a.m.) and afternoon (5:00 p.m.). Psychological variables (Profile of mood states (POMS-f) and Hooper questionnaires) were assessed before and ratings of perceived exertion (RPE) immediately after the RSSJA. Results: Sprint times (p > 0.05) of the six repetition, fatigue index of sprints (p > 0.05) as well as mean (p > 0.05) jump height and fatigue index (p > 0.05) of CMJ did not differ between morning and afternoon. No differences were observed between the two times-of-day for anxiety, anger, confusion, depression, fatigue, interpersonal relationship, sleep, and muscle soreness (p > 0.05). Jump height in CMJ 3 and 4 (p < 0.05) and RPE (p < 0.05) and vigor (p < 0.01) scores were higher in the afternoon compared to the morning. Stress was higher in the morning compared to the afternoon (p < 0.01). Conclusion: In contrast to previous research, repeated sprint running performance and mood states of the tested elite athletes showed no-strong dependency of time-of-day of testing. A possible explanation can be the habituation of the judo athletes to work out early in the morning.
Relationship between procedural characteristics and cerebrovascular events after transcatheter aortic valve replacement

Objectives The objective was to assess the impact of procedural characteristics on risk of stroke or transient ischaemic attack (TIA) after transcatheter aortic valve replacement (TAVR). Methods We included 370 consecutive patients who underwent balloon-expandable TAVR from 1 November 2008 to 30 June 2014. Procedural characteristics that may be associated with stroke/TIA were assessed. The primary outcome was stroke/TIA at 30 days. A propensity score was constructed using a logistic regression model with 29 parameters. Cox proportional hazards models were used with a propensity score covariate. Results Mean age was 80.9±7.9 years and mean Society of Thoracic Surgeons score was 8.3±5.0. The total number of balloon dilations ranged from 2 to 7. Out of 370 patients, 13 patients (3.5%) suffered stroke/TIA in the first 30 days after TAVR. In univariate analysis, postdeployment balloon dilation (PD) (HR 3.8, 95% CI 1.24 to 11.61; p=0.02) and emergent cardiopulmonary bypass (CPB) (HR 9.66, 95% CI 2.66 to 35.15; p<0.001) were significantly associated with 30-day stroke/TIA. In the multivariable Cox-proportional hazards model, PD (HR 4.95, 95% CI 1.02 to 24.03; p=0.04) and emergent CPB (HR 7.15, 95% CI 1.39 to 36.89; p=0.02) were independently associated with increased risk of 30-day stroke/TIA after adjusting for propensity score, total number of balloon dilations and periprosthetic regurgitation. Conclusion Postdilation as compared with total number of dilations, and emergent CPB were independently associated with increased risk of clinical neurological events in the first 30 days after TAVR. Reduction in balloon postdilation with appropriate valve sizing may reduce the risk of stroke or TIA after TAVR.
Non-cardiac chest pain: prognosis and secondary healthcare utilisation

Objective Presentations of non-cardiac chest pain (NCCP) to the emergency department (ED) are increasing. More knowledge of prognosis and healthcare utilisation of patients with NCCP is necessary to optimise their management. Methods This study is a prospective, observational, prevalence-based cohort study conducted from September 2015 to February 2016 with 1-year follow-up including all patients 18 years and older referred to the ED with chest pain. Discharge diagnoses, mortality, major adverse cardiac events (MACE), re-presentations to the ED, hospitalisations, cardiac interventions and outpatient monitoring were assessed. Results More than 60% of the 1239 patients presenting with chest pain were discharged with NCCP. The all-cause 1-year mortality rate of patients with NCCP was 2.3% compared with 7.2% in patients with cardiac chest pain (CCP) (p<0.001) and the occurrence of MACE was 5.1% vs 8.3%, respectively (p=0.026). Previous history of coronary artery disease (CAD) in patients with NCCP was identified as a predictive factor for MACE (OR 4.30 (95% CI 1.24 to 14.89), p=0.021). Patients with NCCP had more non-invasive interventions than patients with CCP (proportion of 0.225 vs 0.165 per patient, p<0.001) and 13.7% of patients with NCCP re-presented at the ED within 1 year. Conclusion The majority of patients referred to the ED with chest pain are discharged with NCCP. The prognosis of patients with NCCP is better than patients with CCP; however, they are at risk for MACE due to a history of CAD. Patients with NCCP moreover use a substantial amount of medical resources, stressing the importance of good triage to minimise unnecessary healthcare utilisation while still preventing MACE.
Multiple tumor suppressors regulate a HIF-dependent negative feedback loop via ISGF3 in human clear cell renal cancer

Whereas VHL inactivation is a primary event in clear cell renal cell carcinoma (ccRCC), the precise mechanism(s) of how this interacts with the secondary mutations in tumor suppressor genes, including PBRM1, KDM5C/JARID1C, SETD2, and/or BAP1, remains unclear. Gene expression analyses reveal that VHL, PBRM1, or KDM5C share a common regulation of interferon response expression signature. Loss of HIF2α, PBRM1, or KDM5C in VHL-/-cells reduces the expression of interferon stimulated gene factor 3 (ISGF3), a transcription factor that regulates the interferon signature. Moreover, loss of SETD2 or BAP1 also reduces the ISGF3 level. Finally, ISGF3 is strongly tumor-suppressive in a xenograft model as its loss significantly enhances tumor growth. Conversely, reactivation of ISGF3 retards tumor growth by PBRM1-deficient ccRCC cells. Thus after VHL inactivation, HIF induces ISGF3, which is reversed by the loss of secondary tumor suppressors, suggesting that this is a key negative feedback loop in ccRCC.
RESTRIÇÃO FINANCEIRA E AGRESSIVIDADE FISCAL NAS EMPRESAS BRASILEIRAS DE CAPITAL ABERTO

O objetivo da pesquisa e inferir se as empresas brasileiras de capital aberto que enfrentam situacoes de restricoes financeiras sao mais agressivas tributariamente. Por hipotese presume-se que as empresas que enfrentam restricoes financeiras, se deparam com fontes de financiamentos tradicionais mais onerosas e/ou mais dificeis de serem obtidas. A relevância do presente estudo esta em evidenciar um possivel incentivo a agressividade tributaria fruto da carencia de fontes de financiamento. Usando tres proxies de agressividade fiscal, os testes realizados parecem indicar que as empresas restritas financeiramente tendem a ser mais agressivas tributariamente para gerar caixa adicional para fazer frente as suas dificuldades financeiras. Os resultados apresentados sao consistentes com a teoria existente, a qual preve uma associacao significativa entre restricao financeira e agressividade tributaria.
Prebiotics, Probiotics, and Acetate Supplementation Prevent Hypertension in a Model of Obstructive Sleep Apnea

Disruption of the gut microbiota, termed gut dysbiosis, has been described in animal models of hypertension and hypertensive patients. We have shown that gut dysbiosis plays a causal role in the development of hypertension in a rat model of obstructive sleep apnea (OSA). Functional analysis of the dysbiotic microbiota in OSA demonstrates a loss of short chain fatty acid–producing bacteria. However, measurements of short chain fatty acid concentrations and testing of their role in blood pressure regulation are lacking. We hypothesized that reduced short chain fatty acids in the gut are responsible for OSA-induced hypertension. OSA significantly increased systolic blood pressure at 7 and 14 days (P<0.05), an effect that was abolished by the probiotic Clostridium butyricum or the prebiotic Hylon VII. The 16S rRNA analysis identified several short chain fatty acid–producing bacteria that were significantly increased by Cbutyricum and Hylon treatment. Acetate concentration in the cecum was decreased by 48% after OSA (P<0.05), an effect that was prevented by Cbutyricum and Hylon. Cbutyricum and Hylon reduced OSA-induced dysbiosis, epithelial goblet cell loss, mucus barrier thinning, and activation of brain microglia (P<0.05 for each). To examine the role of acetate in OSA-induced hypertension, we chronically infused acetate into the cecum during 2 weeks of sham or OSA. Restoring cecal acetate concentration prevented OSA-induced gut inflammation and hypertension (P<0.05). These studies identify acetate as a key player in OSA-induced hypertension. We demonstrate that various methods to increase cecal acetate concentrations are protective from the adverse effects of OSA on the microbiota, gut, brain, and blood pressure.
Factors influencing temporal patterns in crime in a large American city: A predictive analytics perspective

Background Improving the accuracy and precision of predictive analytics for temporal trends in crime necessitates a good understanding of the how exogenous variables, such as weather and holidays, impact crime. Methods We examine 5.7 million reported incidents of crime that occurred in the City of Chicago between 2001 to 2014. Using linear regression methods, we examine the temporal relationship of the crime incidents to weather, holidays, school vacations, day-of-week, and paydays. We correct the data for dominant sources of auto-correlation, and we then employ bootstrap methods for model selection. Importantly for the aspect of predictive analytics, we validate the predictive capabilities of our model on an independent data set; model validation has been almost universally overlooked in the literature on this subject. Results We find significant dependence of crime on time of year, holidays, and weekdays. We find that dependence of aggressive crime on temperature depends on the hour of the day, and whether it takes place outside or inside. In addition, unusually hot/cold days are associated with unusual fluctuations upwards/downwards in crimes of aggression, respectively, regardless of the time of year. Conclusions Including holidays, festivals, and school holiday periods in crime predictive analytics software can improve the accuracy and precision of temporal predictions. We also find that including forecasts for temperature may significantly improve short term crime forecasts for the temporal trends in many types of crime, particularly aggressive crime.
A New and Simple Risk Predictor of Contrast-Induced Nephropathy in Patients Undergoing Primary Percutaneous Coronary Intervention: TIMI Risk Index

Background The thrombolysis in myocardial infarction risk index (TRI) was developed to estimate prognosis at the initial contact of the healthcare provider in coronary artery disease patients without laboratory parameters. In this study, we aimed to investigate the relationship of the baseline TRI and contrast-induced nephropathy (CIN) in patients with ST-elevation myocardial infarction (STEMI). Methods A total of 963 consecutive STEMI diagnosed patients who underwent primary percutaneous intervention were included in the study. TRI was calculated using the formula “heart rate × (age/10) 2/SBP” on admission. CIN was defined as an increase in serum creatinine concentration ≥25%, 48 hours later over the baseline. Results Of the total of 963 patients, CIN was observed in 13% (n=128). TRI was significantly higher in the CIN (+) group compared with the CIN (−) group (32.9 ± 18.8 vs 19.9 ± 9.9, P < 0.001). There was a stronger correlation between CIN and age, diastolic blood pressure, heart rate, Killip class, left ventricular ejection fraction, amount of contrast media, and diabetes mellitus. The amount of contrast media (OR 1.010, 95% CI 1.007–1.012, P < 0.001) and TRI (OR 1.047, 95% CI 1.020–1.075, P=001) were independent predictors of CIN. The best threshold TRI for predicting CIN was ≥25.8, with a 67.1% sensitivity and 80.4% specificity (area under the curve (AUC): 0.740, 95% CI: 0.711–0.768, P < 0.001). Conclusion TRI is an independent predictor of CIN, and it may be used as a simple and reliable risk assessment of CIN in STEMI patients without the need for laboratory parameters.
Placement and Routing by Overlapping and Merging QCA Gates

The QCA gate-level design introduces new challenges to the traditional mapping, placement, and routing flow. First, the wires consume more than 90% of total area. In addition, even a combinational circuit requires a clock scheme, and all internal paths should be balanced. This work proposes a novel approach to automatically map a gate-level circuit onto a QCA layout by using a merge overlapping approach, and a universal clock scheme to provide scalability. First, the circuit is decomposed into a set of overlapping subgraph partitions. This decomposition is guided by reconvergent paths. For each subgraph, more than one customized QCA layout cell is generated on-the-fly. During the last step, a merge overlapping algorithm rebuilds the entire circuit to produce the final layout. All inter and intra-partition wires should be balanced according to the adopted clock scheme. Our approach reduces the total area in more than 50% in comparison to a previous approach based on standard-cell QCA libraries. Finally, all layouts were validated on QCADesigner simulator to verify the design rules.
Parcellation of the Human Cerebral Cortex Based on Molecular Targets in the Serotonin System Quantified by Positron Emission Tomography In vivo

Abstract Parcellation of distinct areas in the cerebral cortex has a long history in neuroscience and is of great value for the study of brain function, specialization, and alterations in neuropsychiatric disorders. Analysis of cytoarchitectonical features has revealed their close association with molecular profiles based on protein density. This provides a rationale for the use of in vivo molecular imaging data for parcellation of the cortex with the advantage of whole-brain coverage. In the current work, parcellation was based on expression of key players of the serotonin neurotransmitter system. Positron emission tomography was carried out for the quantification of serotonin 1A (5-HT1A, n = 30) and 5-HT2A receptors (n = 22), the serotonin-degrading enzyme monoamine oxidase A (MAO-A, n = 32) and the serotonin transporter (5-HTT, n = 24) in healthy participants. Cortical protein distribution maps were obtained using surface-based quantification. Based on k-means clustering, silhouette criterion and bootstrapping, five distinct clusters were identified as the optimal solution. The defined clusters proved of high explanatory value for the effects of psychotropic drugs acting on the serotonin system, such as antidepressants and psychedelics. Therefore, the proposed method constitutes a sensible approach towards integration of multimodal imaging data for research and development in neuropharmacology and psychiatry.
Sex Differences in Renal Inflammation and Injury in High-Fat Diet–Fed Dahl Salt-Sensitive Rats

We examined the impact of sex on high-fat diet (HFD)–induced renal alterations in Dahl salt-sensitive and Sprague Dawley rats. In Dahl rats, HFD (60% kcal from fat for 24–26 weeks starting at weaning) significantly and equally increased blood pressure in males and females when compared with rats fed a control diet (10% kcal from fat). Male Dahl rats on HFD exhibited progressive renal histological injury and moderately increased renal macrophage infiltration at 10 and 24 weeks of feeding when compared with males on control diet. Female Dahl rats had lower grade renal injury and less macrophage infiltration (except at 17 weeks) than males regardless of diet. Male Dahl rats on both diets showed progressively increasing numbers of renal T-cells, a pattern not observed in females. HFD per se did not significantly affect renal T-cell number. Male Dahl rats had lower renal regulatory T-cells cell ratio than females at 24 weeks. Renal macrophage and T-cell infiltrations were highly correlated to final mean arterial pressure levels in males but not in females. Sprague Dawley rats fed HFD were normotensive without significant renal injury/inflammation after 24 weeks of feeding. In summary, HFD feeding fails to increase arterial blood pressure in Sprague Dawley rats but strongly promotes hypertension in both male and female Dahl salt-sensitive rats. Only Dahl males, however, exhibited blood pressure-associated renal inflammation and injury. Maintenance of regulatory T-cells ratio may protect against hypertension-associated renal injury/inflammation but not HFD-induced hypertension.
To Fuse or Not to Fuse.

During development, remodeling of the vasculature is critical for embryonic survival such that mouse embryos cannot live past embryonic days (E) 9.5 to 10.5 if they fail to remodel their blood vessels. Vascular fusion is the process by which vessels enlarge during early development to establish vascular networks and larger vessels, for example, the aorta. Vascular fusion begins with the reduction of the avascular region between 2 vessels subsequently bringing 2 neighboring small caliber vessels close to one another. When these vessels come into contact, the endothelial cells reorganize their cell-cell junctions to create one larger vessel with one common lumen. The molecular signaling events governing this process have not been fully identified.
Social Reactions to Intimate Partner Violence Disclosure Among Low-Income, Ethnically Diverse Community Women

Friends and family members’ reactions to intimate partner violence (IPV) disclosure play an important role in social support because disclosure often precedes requests for support. Perceptions of social reactions to IPV disclosure are likely to vary by context. Yet, research is limited on the role of ethnicity and severity of physical violence in perceptions of social reactions. We examined perceptions of social reactions to IPV disclosure using data from Wave 6 interviews for Project HOW: Health Outcomes of Women. Participants (N = 201) were asked proportionately how many friends and family reacted positively and negatively to IPV disclosure. MANOVAs revealed significant differences in perceptions of positive social reactions by ethnicity and severity.
Industrial IoT Monitoring: Technologies and Architecture Proposal

Dependability and standardization are essential to the adoption of Wireless Sensor Networks (WSN) in industrial applications. Standards such as ZigBee, WirelessHART, ISA100.11a and WIA-PA are, nowadays, at the basis of the main process-automation technologies. However, despite the success of these standards, management of WSNs is still an open topic, which clearly is an obstacle to dependability. Existing diagnostic tools are mostly application- or problem-specific, and do not support standard-based multi-network monitoring. This paper proposes a WSN monitoring architecture for process-automation technologies that addresses the mentioned limitations. Specifically, the architecture has low impact on sensor node resources, uses network metrics already available in industrial standards, and takes advantage of widely used management standards to share the monitoring information. The proposed architecture was validated through prototyping, and the obtained performance results are presented and discussed in the final part of the paper. In addition to proposing a monitoring architecture, the paper provides an in-depth insight into metrics, techniques, management protocols, and standards applicable to industrial WSNs.