Miracle-dz/UniFAR-FTUs huggingface dataset:
EVIDENCE FOR THE PRESENCE OF LIPOFIBROBLASTS IN HUMAN LUNG

The lipid-containing alveolar interstitial fibroblast (lipofibroblast) is known to be critically involved in rodent lung development, homeostasis, and injury/repair. However, there is lack of information on their presence and function in the human lung. Based on a number of morphological (lipid staining), molecular (presence of characteristic lipogenic and absence of myogenic markers), and functional (triglyceride uptake) characteristics that are the hallmarks of the rodent lung lipofibroblast, using human lung fibroblasts of embryonic (WI-38) and adult origin and lung tissue from human autopsy specimens, the authors for the first time clearly demonstrate the presence of lipofibroblasts in the human lung.
Measurement of Deep Tissue Implanted Antenna Efficiency Using a Reverberation Chamber

We investigate the use of a reverberation chamber for the experimental measurement of deep implant antenna radiation efficiency. The technique was able to measure the extremely low efficiencies associated with deep implant antennas inside a muscle tissue-mimicking liquid phantom. Results were obtained for a range of insulated and un-insulated antennas with efficiencies as low as 0.06%. Analysis showed that while measurement errors were dominated by positioning variability, spurious feed cable radiation is still a significant factor that must be considered. Depending on the radiation characteristics of the antenna under test and the feed cable routing within the phantom, cable radiation could lead to errors of up to 4.5 dB.
Factors Contributing to Kidney Allograft Loss and Associated Consequences among Post Kidney Transplantation Patients

Background: Progress has been made in the multifactorial field of kidney transplantation over the last two decades. However, the survival of kidney allografts continues to be short for most recipients due to several factors that contribute to kidney allograft loss. This presents with detrimental effects on the outcome of post kidney transplant patients. Objectives: The objective of the review is to highlight factors contributing to kidney allograft loss and associated consequences among post kidney transplant patients. Methods: The following databases provided literature through online search: CINAHL, EBSCO, Google Scholar, PubMed and grey search. This study included English written articles that are published between 2001 and 2017 with the full text identified using the keywords: Contributing factors to graft loss, associated consequences of graft loss, Kidney transplantation, kidney rejection, kidney allograft loss, Transplant rejection, post kidney, transplantation patients. Results: The identified factors contributing to kidney allograft loss are patient related, donor related, physiological related, therapy related and socioeconomic factors. The identified consequences include Back to Dialysis, High Mortality Rate, Re-transplantation, Lower Quality of Life and Higher Health Care Expenditure. Conclusion: Contributing factors to kidney allograft loss are multifactorial. Therefore, identification of these factors and associated consequences related to kidney allograft loss will assist in identifying gaps in transplant management and consequently improve on long-term graft survival.
THE BACTERIOLOGY OF ACNE.

A total of 175 acne lesions, including comedones, papules, pustules, and cysts were examined bacteriologically by smear and culture. The bacteriology of acne is simple. Two organisms, Corynebacterium acnes and Staphylococcus albus , usually in combination, occupy the various types of acne lesions almost exclusively. Both are regarded as contributors to pathogenesis by secondary infection.
Effect of Dipeptidyl Peptidase-4 Inhibitors on Bone Metabolism and the Possible Underlying Mechanisms

Diabetes mellitus has been demonstrated to be closely associated with osteoporosis. Accordingly, hypoglycemic therapy is considered effective in treating metabolic bone disease. Recently, the effects of dipeptidyl peptidase-4 (DPP-4) inhibitors, a new type of antidiabetic drug, on bone metabolism have been widely studied. This review mainly describes the effects of DPP-4 inhibitors on bone metabolism, including their effects on bone mineral density, bone quality, and fracture risk. In addition, the potential underlying mechanisms are discussed. Based on the current progress in this research field, DPP-4 inhibitors have been proved to reduce fracture risk. In addition, sitagliptin, a strong and highly selective DPP-4 inhibitor, showed its beneficial effects on bone metabolism by improving bone mineral density, bone quality, and bone markers. With regard to the potential underlying mechanisms, DPP-4 inhibitors may promote bone formation and reduce bone resorption through DPP-4 substrates and DPP-4-related energy metabolism. Vitamin D and other related signaling pathways also play a role in affecting bone metabolism. Although these assumptions are controversial, they provide a translational pharmacology approach for the clinical use of DPP-4 inhibitors in the treatment of metabolic diseases. Prior to the use of these drugs in clinic, further studies should be conducted to determine the appropriate type of DPP-4 inhibitor, the people who would benefit the most from this therapy, appropriate dose and duration, and the effects of the treatment.
Is cognitive behavioural therapy effective in reducing suicidal ideation and behaviour when delivered face-to-face or via e-health? A systematic review and meta-analysis

Abstract Cognitive Behavioural Therapy (CBT) is a widely used psychotherapeutic intervention for suicide prevention despite its efficacy for suicide prevention in adults remaining ambiguous. Reluctance or inability to access face-to-face help suggests that e-health delivery may be a valuable resource for suicidal people. The aim of this study was to systematically review and conduct meta-analysis on research assessing the efficacy of CBT delivered via face-to-face and e-health for suicidal ideation and behaviour. A comprehensive literature search of MEDLINE, PsycINFO, Scopus, PubMed and The Cochrane Central Register of Controlled Trials was conducted. From 764 identified articles, 26 met the inclusion criteria for investigating CBT for suicidal ideation and behaviours in adult populations. Data were extracted on study characteristics and meta-analysis was performed where possible. There was a statistically significant, small to medium effect for face-to-face delivered CBT in reducing suicidal ideation and behaviour although there was significant heterogeneity between the included studies. CBT delivered via e-health was not found to be efficacious for reducing suicidal ideation and behaviour in adults though the number of studies reviewed was small.
Automated stroke volume and pulse pressure variations predict fluid responsiveness in mechanically ventilated patients with obstructive jaundice.

BACKGROUND AND OBJECTIVES Stroke volume variation (SVV) and the pulse pressure variation (PPV) have been found to be effective in prediction fluid responsiveness especially in high risk operations. The objective of this study is to validate the ability of SVV obtained by FloTrac/Vigileo system and PPV obtained by IntelliVue MP System to predict fluid responsiveness in patients with obstructive jaundice during mechanical ventilation. METHODS Twentyfive patients with obstructive jaundice (mean serum total bilirubin 175.0 ± 120.8 μmol/L), who accepted volume expansion and were hemodynamically stable after induction of anesthesia, were included in the study. SVV and PPV were recorded simultaneously before and after an intravascular volume expansion. Patients with a stroke volume index (SVI) increase of more than 10% after volume expansion were considered as responders. RESULTS The agreement (mean bias ± SD) between SVV and PPV was -0.2% ± 1.56%. Before volume expansion, SVV and PPV were significantly higher in responders compared to non-responders (P<0.001, P<0.001). Significant correlation was observed between the baseline value of SVV and PPV and the percent change in SVI after fluid expansion (r=0.654, P<0.001; r=0.592, P=0.002). Area under the receiver operating characteristic curves of SVV (0.955) and PPV (0.875) were comparable (P=0.09). The optimal threshold values in predicting fluid responsiveness were 10% for SVV and 8% for PPV. CONCLUSION In conclusion, SVV obtained by FloTrac/Vigileo system and PPV obtained by IntelliVue MP System was able to predict fluid responsiveness in patients with obstructive jaundice.
Modeling and Design Considerations of a Novel High-Gain Peak Current Control Scheme to Achieve Adaptive Voltage Positioning (AVP) for DC Power Converters

Peak current control (PCC) can be used to achieve adaptive voltage positioning (AVP) in DC power converters for CPU power applications. However, PCC is seldom used because of the problem with output voltage offset from the target load line. A novel high-gain PCC (HGPCC) AVP scheme was recently reported to correct the aforementioned offset problem while retaining the advantages of PCC, such as easy phase-current balancing, inherently cycle-to-cycle protection, and good stability margin. Without an analytical model, however, it is very hard to achieve prescribed characteristics using this complicated scheme. In this paper, a control model and design considerations will be presented for this scheme. Key equations for converter feedback performance and rules for compensating the feedback loop will be presented. The proposed model was experimentally verified.
Differential Transcriptome Analysis of Diabetes-Resistant and -Sensitive Mouse Islets Reveals Significant Overlap With Human Diabetes Susceptibility Genes

Type 2 diabetes in humans and in obese mice is polygenic. In recent genome-wide association studies, genetic markers explaining a small portion of the genetic contribution to the disease were discovered. However, functional evidence linking these genes with the pathogenesis of diabetes is scarce. We performed RNA sequencing–based transcriptomics of islets from two obese mouse strains, a diabetes-susceptible (NZO) and a diabetes-resistant (B6-ob/ob) mouse, after a short glucose challenge and compared these results with human data. Alignment of 2,328 differentially expressed genes to 106 human diabetes candidate genes revealed an overlap of 20 genes, including TCF7L2, IGFBP2, CDKN2A, CDKN2B, GRB10, and PRC1. The data provide a functional validation of human diabetes candidate genes, including those involved in regulating islet cell recovery and proliferation, and identify additional candidates that could be involved in human β-cell failure.
Topical tacrolimus 0.1% ointment (Protopic®) reverses nickel contact dermatitis elicited by allergen challenge to a similar degree to mometasone furoate 0.1% with greater suppression of late erythema

The aim of this study was to evaluate the ability of topical tacrolimus 0.1% under occlusion for 48 h to suppress nickel‐elicited allergic contact dermatitis in a randomized, petrolatum‐ and mometasone furoate 0.1% ointment‐controlled double‐blind, intra‐individual study which included 28 women volunteers. 3 closed patch tests (Finn Chambers® on Scanpor, Epitest Ltd Oy, Tuusula, Finland) containing 0.1 ml of 5% nickel sulfate in petrolatum were applied on day 0. After removal on day 2, the study compounds were applied under occlusion for 48 h. The eczema reaction and the degree of erythema were evaluated clinically and by reflectance spectrophotometry at days 4 and 7, respectively. Mean visual scores corresponding to petrolatum‐treated sites were significantly higher than those corresponding to both mometasone furoate and tacrolimus at days 4 (P < 0.001) and 7 (P < 0.001). In both tacrolimus‐ and mometasone furoate‐treated sites, there was a significant decrease in visual scores with time (P < 0.001) from day 2 to day 7, and the corresponding mean decreases in scores were 0.73 and 1.04, respectively. The difference between both was 0.30 in favour of tacrolimus (95% confidence intervals, −0.04 and 0.65), although this did not reach statistical significance (P = 0.084). Mean erythema index values were similar at day 2. Significant differences among treatment sites were seen at days 4 (P < 0.001) and 7 (P < 0.001). The decrease was significantly more pronounced on day 7 in patches where tacrolimus had been supplied (P < 0.5). This method might provide useful means to compare different concentrations and/or presentations of tacrolimus or other calcineurin inhibitors and topical anti‐inflammatory agents.
Neuroprotective Effects of Riluzole and Ketamine during Transient Spinal Cord Ischemia in the Rabbit

BackgroundMassive release of central excitatory neurotransmitters is an important initial step in ischemic neuronal injury, and modification of this process may provide neuroprotection. We studied the protective effects of the voltage-dependent sodium channel antagonist riluzole and the N-methyl-d-aspartate receptor antagonist ketamine on hind limb motor function and histopathologic outcome in an experimental model of spinal cord ischemia. MethodsTemporary spinal cord ischemia was induced by 29 min of infrarenal balloon occlusion of the aorta in 60 anesthetized New Zealand white rabbits. Animals were randomly assigned to one of four treatment groups (n = 15 each): group C, saline (control); group R, riluzole, 8 mg/kg intravenously; group K, ketamine, 55 mg/kg intravenously; group RK, riluzole and ketamine. After reperfusion, riluzole treatment was continued with intraperitoneal infusions. Normothermia (38°C) was maintained during ischemia, and rectal temperature was assessed before and after intraperitoneal infusions. Neurologic function, according to Tarlov’s criteria, was evaluated every 24 h, and infarction volume and the number of eosinophilic neurons and viable motoneurons in the lumbosacral spinal cord was evaluated after 72 h. ResultsNeurologic outcome was better in groups R and RK than in groups C and K. All animals in group C (100%) and all animals but one in group K (93%) were paraplegic 72 h after the ischemic insult versus 53% in group R and 67% in group RK (P < 0.01 each). More viable motoneurons were present in groups R and RK than in controls (P < 0.05). ConclusionsThe data indicate that treatment with riluzole can increase the tolerance of spinal cord motoneurons to a period of normothermic ischemia. Intraischemic ketamine did not provide neuroprotection in this model.
MRI findings in Susac’s syndrome

To the Editor: We read with interest the article by Susac et al.1 describing the MRI findings in Susac syndrome (SS). Recently, we saw a 26-year-old man whose MRI findings were typical of SS (figure 1), and in whom the diagnosis of demyelinating disease was considered. However, on diffusion-weighted MRI (DWI), the lesions were hyperintense (figure 2), and this prompted a successful clinical review for the triad of SS and the correct diagnosis. The DWI appearance of SS may not have been described before, but our findings would be consistent with the pathologic process of small arteriolar occlusion and microinfarction of the brain.2 The MRI pattern and ophthalmic findings in SS are similar to our prior experience with Nipah virus encephalitis, a rare pig-borne infection that also resulted in branch retinal artery occlusion and identical small DWI lesions within the white matter, including corpus callosum.3 Our observation of DWI abnormalities in both SS and Nipah virus infection probably reflects similar ischemic pathology.4 Although hyperintense lesions on DWI are typical of acute cerebral infarction, they are not common in multiple sclerosis (MS). This distinction may be clinically relevant as typical MRI findings in SS are often misinterpreted as MS. DWI may be useful in the differential diagnosis of SS, especially among patients in whom the triad is absent.
Is dedicated extremity 1.5-T MRI equivalent to standard large-bore 1.5-T MRI for foot and knee examinations?

OBJECTIVE The purpose of this study was to prospectively compare dedicated extremity MRI and standard large-bore MRI of the lower extremities in the same patients. SUBJECTS AND METHODS Sixty-nine patients (27 feet and 42 knees) were examined both with extremity 1.5-T MRI and standard 1.5-T MRI. Scanning duration was measured, and patients completed a detailed questionnaire after each examination (4-point scale). Two readers assessed image quality parameters. Data were analyzed with the paired Student t test, Wilcoxon signed rank test, and chi-square test. RESULTS Scanning duration was significantly longer for extremity MRI (foot, 29.9±5.5 minutes; knee, 30.4±5.6 minutes) than for standard MRI (foot, 21.9±5.0 minutes; knee, 20.5±3.9 minutes) (p<0.001 for all comparisons). Acoustic noise reported by the patient was significantly lower on extremity MRI (foot, 1.9±0.9; knee, 2.1±0.7) compared with standard MRI (foot, 2.9±1.0; knee, 2.9±0.8) (p<0.001 for all). Patient satisfaction for both systems was high (1.4-1.6 for all, p=0.2-1.0). Image quality and fat suppression were equally good for both scanners for foot examinations (p≥0.48). Knee examinations generally featured good image quality on both systems, but standard MRI had superior image quality (p≤0.01) and fat suppression (p≤0.001) compared with extremity MRI. More motion artifacts were present on extremity MRI than on standard MRI, which was significant for the knee (p≤0.04) but not for the foot (p≥0.32). CONCLUSION Extremity MRI featured less acoustic noise than standard MRI, but examination duration was longer on extremity MRI. Patient satisfaction was high for both scanners. For foot examinations, image quality on extremity MRI was equivalent to standard MRI. Image quality for knee examinations was better on standard MRI compared with extremity MRI, but overall it was good on both systems.
Sequestrate species of Agaricus and Macrolepiota from Australia: new species and combinations and their position in a calibrated phylogeny

Australian collections of sequestrate Agaricaceae were examined with morphological and molecular data (nuclear DNA from ITS and LSU), and the majority were found to belong to the genera Agaricus and Macrolepiota. Previously described Australian species of Endoptychum are transferred to the appropriate agaricoid genera and several new combinations proposed. Descriptions and illustrations are provided for these and eight new species: Agaricus eburneocanus sp. nov., A. chartaceus sp. nov., A. erythrosarx sp. nov., A. inilleasper sp. nov., A. pachydermus sp. nov., Macrolepiota gasteroidea sp. nov., M. vinaceofibrillosa sp. nov. and M. turbinata sp. nov. The sequestrate genus Barcheria is retained as a distinct taxon. Timing of evolution of sequestrate sporocarp forms in Macrolepiota, Chlorophyllum and Agaricus seems to have occurred in the past 15 000 000 y, and a stem age is approximately 65 000 000 y for Barcheria.
Resistance to phytopathogens e tutti quanti: placing plant quantitative disease resistance on the map.

Plant disease resistance can be seen as a process of a dual nature: both qualitative and quantitative.The nature of non-self molecules perceived by plants has led to the depiction of plant immunity as a two-layer defence system. The first layer is mediated by cell surface and intracellular pattern recognition receptors (PRRs) which perceive conserved microbial elicitors, termed pathogenassociated molecular patterns (PAMPs). The perception of these conserved elicitors initiates cascades of signalling and transcription events, known as PAMP-triggered immunity (PTI). Adapted pathogens secrete effector molecules able to suppress PTI, but which may also be recognized by plant intracellular resistance (R) proteins. This initiates effector-triggered immunity (ETI), the second layer of plant defence. ETI typically yields complete disease resistance phenotypes against pathogens containing the recognized effector, a process designated as qualitative resistance. By contrast, perception of a single PAMP typically has a weaker contribution to overall plant resistance. More generally, in the absence of qualitative resistance, an incomplete resistance phenomenon is often observed, leading to a reduction rather than absence of disease. This is usually referred to as quantitative disease resistance (QDR). The definition of QDR varies in the literature according to the interests of the authors, so that the QDR concept may be puzzling. We settled to define QDR based on the simultaneous occurrence of two observations: (i) the disease resistance phenotype follows a continuous distribution from susceptibility to resistance in host populations, as opposed to the ‘susceptibility or resistance’ binary phenotype observed in qualitative resistance (Fig. 1A); and (ii) the disease resistance phenotype is determined by multiple quantitative trait loci (QTLs) as revealed by crossing host parents with contrasted phenotypes. As a consequence, full disease resistance can be achieved by the introduction of a single R gene, but not by the introduction of a single QDR gene, in a susceptible genetic background. Based on this definition, the molecular architecture of QDR can be hypothesized as an intricate network integrating multiple response pathways to several pathogen molecular determinants and environmental cues (Fig. 1B). THE QUALITATIVE–QUANTITATIVE DUALITY OF PLANT DISEASE RESISTANCE
Partial characterization of hormone-mediated inhibition of embryo development in rabbit oviduct fluid.

In vitro studies were conducted to confirm the deleterious effect of exogenous estrogen in vivo on rabbit embryo cleavage. Pronuclear rabbit zygotes were cultured in oviduct fluid and in serum obtained under varying hormonal conditions. 27% of the zygotes cultured in estrogen-influenced oviduct fluid and 24% of those in serum developed normally to the morula stage. Conversely when oviduct fluid and serum were influenced by progesterone the rates of normal development were 74% and 85% respectively. Pharmacological doses of estradiol or progesterone in serum from ovariectomized animals did not inhibit embryo development which suggests that the effects are not direct but are hormonally mediated. Estrogen-mediated inhibition of embryo growth was abolished upon dialysis against control medium. Nonetheless the addition of all cofactors and amino acids in control medium to inhibitory oviduct fluid inhibited normal embryo development. The results suggest the existence of an estrogen-mediated low molecular weight inhibitor of embryo growth in oviduct fluid.
Point‐of‐care testing shows clinically relevant variation in the degree of inhibition of platelets by standard‐dose abciximab therapy during percutaneous coronary intervention

Administration of GP IIb/IIIa inhibitors during percutaneous coronary intervention (PCI) has proven clinical benefit, but is administered at a dose allowing for the patients' weight but not other variables. This study of 75 patients evaluated platelet inhibition achieved by standard‐dose abciximab therapy during PCI as measured by two point‐of‐care (POC) instruments, Plateletworks (PW) and whole blood aggregation (WB). Results were related to the decrease of platelet activation produced as well as patients' return of angina within 30 days. Flow cytometric measurement showed abciximab suppressed platelet‐monocyte aggregates (P < 0.001) and activated glycoprotein IIb/IIIa (P < 0.001) but not P‐selectin. Greater POC‐measured inhibition corresponded to less postabciximab expression of platelet‐monocyte aggregates (P < 0.01). Patients above the lowest quartile of POC inhibition with PW demonstrated a relative risk of experiencing return of angina within 30 days of 0.48 (0.23–0.99). In conclusion, POC measurements reflect platelet activation suppression, higher PW measurements being associated with a decreased risk of return of angina. Catheter Cardiovasc Interv 2004;62:150–154. © 2004 Wiley‐Liss, Inc.