Miracle-dz/UniFAR-FTUs huggingface dataset:
Histologic Examination of the Protective Effect of Vitamin E and C in Cisplatin-Induced Hepatotoxicity

Objectives: We investigated the morphologic changes showing hepatocellular damage caused by the chronic use of cisplatin, an antineoplastic agent, and the protective effect of vitamins E and C. Study Design: Twenty-four Wistar albino male rats were randomly assigned to four groups, equal in number, to receive intravenous 5 mg/kg of cisplatin once a month for three months except for the control rats (group 1). The rats in group 3 and 4 also received daily intramuscular injections of 5 mg/kg of vitamin E and 8 mg/kg of vitamin C, respectively. At the end of three months, the livers were removed for light and electron microscopic examinations. Results: Control rats showed a normal liver tissue structure. Group 2 rats exhibited disorganization of the Remaka#39;s fibers, thickening of the basement membrane together with dilatation of the sinusoids near the centrolobular vein, and lymphocyte infiltration in the portal areas. In vitamin E-treated rats, there was a significant decrease in morphological damage, with disappearance of lymphocyte infiltration in the portal areas. Vitamin C-treated rats manifested the least morphological damage, with a rare infiltration to portal areas and decreased number of infiltration cells. Conclusion: Our findings suggest that the use of antioxidants of different properties may help reduce cisplatin hepatotoxicity, thus contributing to clinical applications. Turkish Baslik: E ve C Vitaminlerinin Cisplatin Hepatotoksisitesini Onlemedeki Etkilerinin Histolojik Olarak Incelenmesi Anahtar Kelimeler: Antineoplastik ajan; cisplatin/toksisite/yan etki; karaciger/ilac etkisi; sican; vitamin C/terapotik kullanim; vitamin E/terapotik kullanim Amac: Bu calismada, bir antineoplastik ajan olan cisplatinin kronik uygulandiginda yol actigi karaciger hasari ve bu hasara karsi E ve C vitaminlerinin ne olcude koruma saglayacagi histolojik olarak incelendi. Calisma Plani: Calismada, 24 adet Wistar albino cinsi erkek sican altisarli dort gruba ayrildi. Kontrol grubu disindaki (grup 1) deneklere uc ay boyunca, ayda bir kez 5 mg/kg cisplatin intravenoz yolla verildi. Grup 3 ve 4a#39;teki deneklere ise ayrica, her gun intramuskuler yolla sirasiyla 5 mg/kg E vitamini ve 8 mg/kg C vitamini verildi. Deney suresinin sonunda, tum deneklerin karaciger materyalleri alinarak isik ve elektron mikroskobisi ile incelendi. Bulgular: Kontrol grubu deneklerde normal yapida karaciger dokusu gozlendi. Ikinci grupta Remak kordonlari nda duzensizlesme, V. centrolobularisa#39;e yakin sinuzoidlerde genisleme ile birlikte bazal membranlarda kalinlasma, portal sahalarda ise lenfosit infiltrasyonu goruldu. Ucuncu grupta morfolojik hasari n buyuk oranda azaldigi, cogu portal sahada lenfosit infiltrasyonunun ortadan kalktigi; dorduncu grupta ise duzelmenin daha da belirginleserek portal saha infiltrasyon bolge sayisinin hem seyreldigi hem de infiltrasyon hucre sayisinin cok azaldigi goruldu. Sonuc: Farkli ozelliklere sahip antioksidanlarin cisplatinin hepatotoksisitesinin azalmasina yardimci olarak klinik uygulamaya katkida bulunacagi sonucuna varildi.
Molecular Pharmacology and Preclinical Studies of Novel Small-molecule Targeted Agents for The Treatment of Hepatocellular Carcinoma

In hepatocellular carcinoma (HCC), the uncontrolled hyperactivity of both Akt and nuclear factor-κB (NF-κB) is commonly associated with tumor development and progression. Indole-3-carbinol, a chemopreventive phytochemical, was used as the base for the synthesis of a novel derivative, [1-(4-chloro3-nitrobenzenesulfonyl)-1H-indol-3yl]-methanol (OSU-A9). OSU-A9 shows a much higher potency than its parent drug in inducing apoptosis in many cancer cell lines by targeting, at least in part, the Akt-NF-κB signaling network. In this study, we aimed to assess the antitumor activity of OSU-A9 using both in vitro and in vivo models of HCC, a malignancy in which the Akt-NF-κB signaling network plays major roles in pathogenesis and therapeutic resistance. Our data show that OSU-A9 was about 100 times more potent than indole-3-carbinol in suppressing the viability of Hep3B, Huh7, and PLC5 cells with IC50 values ranging from 2.8 to 3.2 μM. OSU-A9 interfered with the interaction between Akt and NF-κB mediated oncogenic signaling, leading to changes in the functional status of diverse signaling effectors involved in cell cycle progression, apoptosis, angiogenesis, and metastasis. The 21 in vivo efficacy of OSU-A9 was assessed in nude mice bearing luciferase-expressing Hep3B xenograft tumors. Daily oral treatments with OSU-A9 at 25 or 50 mg/kg for 56 days suppressed tumor growth by 67 and 80%, respectively, which was correlated with changes in intratumoral biomarkers pertinent to Akt-NF-κB signaling inhibition, and without apparent toxicity or evidence of hepatic biotransformation enzyme induction. Together, these findings indicate that OSU-A9 is a potent, orally bioavailable inhibitor of the Akt-NF-κB signaling network with a broad spectrum of antitumor activity that includes targets regulating multiple aspects of HCC pathogenesis and progression.
Doing Educational Research

One day, you will discover a new adventure and knowledge by spending more money. But when? Do you think that you need to obtain those all requirements when having much money? Why don't you try to get something simple at first? That's something that will lead you to know more about the world, adventure, some places, history, entertainment, and more? It is your own time to continue reading habit. One of the books you can enjoy now is doing educational research here.
Influence of the Lumbar Spine Adjustment using the Lumbar Roll Support on Head and Neck Posture in Older Adults

The objective of this study was to identify the effect of lumbar lordotic curve adjustment on head and neck posture in older adults. Methods Twenty healthy older participants (mean age 71.32) were photographed while watching monitor in sitting with or without lumbar roll support(length 28cm, diameter 10cm). The upper cervical angle and lower cervical angle were measured using the NIH ImageJ 1.32. Comparisons between upper and lower cervical angle with or without lumbar roll support were made using paired-t test analysis. Results Subjects demonstrated a significant difference in the mean upper and lower cervical angle. Mean difference of the upper cervical angle was about 2.83° with and without lumbar roll support(p<0.005). Mean difference of the lower cervical angle was about 4.44° with and without lumbar roll support(p<0.0001). Conclusions This study showed that healthy older adults demonstrated more ability to maintain an upright posture of cervical spine during lumbar lordotic curve maintenance with lumbar roll support than without lumbar roll support. When the clinicians consider improvement of the head and neck posture in older adults, they must incorporate adjustment in the lumbar region. ■ keyword :∣Lumbar Lordotic Curve Adjustment∣Head and Neck Posture∣Lumbar Roll Support∣ 접수번호 : #110928-005 접수일자 : 2011년 09월 28일 심사완료일 : 2011년 10월 28일 교신저자 : 윤범철, e-mail : yoonbc@korea.ac. kr 요추 지지대에 의한 노인의 요추만곡 조절이 머리와 목 자세에 미치는 영향 801
A comparison of routing strategies for vehicular ad-hoc networks

On this paper we investigate the use of ad-hoc routing algorithms for the exchange of data between vehicles. There are two main aspects that are of interest in this context: the specific characteristics of ad-hoc networks formed by vehicles and the applicability of existing ad-hoc routing schemes to networks that display these characteristics. In order to address both aspects we generate realistic vehicular movement patterns of highway traffic scenarios using a well validated traffic simulation tool. Based on these patterns we show that the characteristics of vehicular ad-hoc networks are quite different from the frequently used random waypoint model. We then proceed to evaluate the performance of a reactive ad-hoc routing protocol (DSR) and of a position-based approach (greedy forwarding as done in GPSR) in combination with a simple reactive location service. Our analysis suggests that for vehicular networks where communication spans more than 2 or 3 hops position-! based ad-hoc routing has significant advantages over reactive non-position-based approaches both in the number of successfully delivered packets and in routing overhead.
Situation of Artificial Depigmentation among Women in 2016 to Bobo-Dioulasso, Burkina Faso

INTRODUCTION: The artificial depigmentation (DA) is a practice that aims to reduce the natural pigmentation of the skin by the use of depigmenting products (DP). In Burkina Faso, few studies have been made on the issue and the last date of 2003. The objective of the study is to realize an overview of the DA phenomenon in women population in Bobo-Dioulasso City. METHODS: This is a descriptive cross-sectional study held from April 16th to April 30th 2016 including 437 women aged from 13 to 55 years old. A multi-stage random sampling was realized A chi-square test was used to compare groups with significant threshold of 5%. RESULTS: The prevalence of the use of DP (67.28% with IC95 = [63.52 - 71.03]). The mean age of users was 27.5 years old; the typical profile was women from 30 to 35 years old (85.7%), with elementary study level, (73.47%), housewife’s (75.19%) and monogamous (71.98%). the products used was those made of hydroquinone (81.6%), EDTA (8.33%), kojic acid (4.86%), mixtures (11.12%) or unknown products (14.58%). The origin of the product was doubtful for almost all the cases (98.96%). The monthly mean cost of this practice for a single user is 1710 CFA. Complications were reported in 62.5% of users, and the most found was dyschromia (85.87%), acne (17.39%) and burns (10.32%). DISCUSSION: The DA is in great progress in Bobo-Dioulasso (2 out of 3 women) compared to half, thirteen years ago. The hydroquinone was markedly the most frequent DP while there was an apparent lack of corticosteroids and mercuries replaced by the new depigmenting agent such as EDTA and kojic acid. This result contrasted with the classic combination hydroquinone-dermocorticoid-mercuries reported by previous studies. CONCLUSION: The low-cost of DP could explain the magnitude of the artificial depigmentation phenomenon. Other studies should be conducted in order to establish with precision the composition of these products and their causality in the occurrence of common complications. Research in cosmetology should make it possible to provide women with safe products that respect their deep needs.
Milk fluoridation for the prevention of dental caries

The good news is that dental caries is preventable through the effective use of fluoride. WHO emphasizes the importance of automatic admin istration of fluoride as part of public health programmes. Substantial research has provided evidence of the effectiveness of milk fluorida tion in the prevention of dental caries. As milk fluoridation mostly tar gets the child population, such schemes have been established within the context of school health programmes and programmes for healthy diet and nutrition. This publication describes the justification of milk fluoridation as an effective public health measure and experiences from community health programmes are highlighted.
Efficient, Software-Only Data Race Exceptions

Data races complicate programming language semantics, and a data race is often a bug. Existing techniques detect data races and define their semantics by detecting conflicts between synchronization-free regions (SFRs). However, such techniques either modify hardware or slow programs dramatically, preventing always-on use today. This paper describes Valor, a sound, precise, softwareonly region conflict detection analysis that achieves high performance by eliminating costly analysis on each read operation that prior approaches require. Valor instead logs a region’s reads and lazily detects conflicts for logged reads when the region ends. We have also developed FastRCD, a conflict detector that leverages the epoch optimization strategy of the FastTrack data race detector. We evaluate Valor, FastRCD, and FastTrack, showing that Valor dramatically outperforms FastRCD and FastTrack. Valor is the first region conflict detector to provide strong semantic guarantees for data races with under 2X slowdown. We also show that Valor is an effective data race detector, providing an appealing cost‐coverage tradeoff compared with FastTrack. Overall, Valor advances the state of the art in always-on support for strong behavioral guarantees for data races, and in sound, precise race detection.
On Competition and Learning in Cortical Structures

How do our brains make us live our lives? Despite the tremendous progress life sciences have made in the last decades we have no conclusive answer to this question. Today we are, however, able to build machines that outperform us in many ways. We can’t calculate as fast as our machines do, nor can we win against them when playing Backgammon, Chess, or Jeopardy. The paradigms upon which they function are fundamentally different from what we know about neural computation. Not only the computational substrate, but the very nature of human intelligence seems fundamentally different from the artificial intelligence (AI) we put into our machines. Existing computational models can be subdivided in two broad classes: (i) top-down models like the AI examples mentioned above that aim to reproduce high-level abilities, without worrying whether the model is in any way similar to the implementation in our brains, and (ii) bottom-up models that focus on using biologically plausible modules that are based on established neurophysiological and neuroanatomical knowledge. The ultimate goal is to understand the detailed neural correlates of cognition – a goal that is currently out of reach. In the first part of this thesis we use classical models for cortical competition to build adaptive systems that are capable of learning the relation between two input modalities. We go on to show that a similar system can be used to sharpen the connectivity in a network of interconnected areas.
Young people using crack and the process of marginalization

Thirty current and former crack users aged 16–24 years participated in a qualitative study about their crack use and related behaviours. The study investigates the process of marginalization (social relations, sources of income and health situation) before and after the start of crack use. Results show that because many crack users were raised in a problematic home situation and have little education, they were already in a marginal position before they started using crack. However, the use of crack accelerated the process of marginalization, because they experienced a shrinking social network that developed around other users, and because they performed illegal activities to buy crack. As result, many users spent time in prison. Regarding health, they experienced respiratory problems, deteriorating physical fitness, paranoia and heart palpitations. Furthermore, homelessness and crack use are intertwined.
Theorizing liminal cinema: Unsettling the transnational spaces of Italian Indian co-productions

This article seeks to provide a contribution to the contemporary writing on transnational cinema. By acknowledging the prolific literature that characterizes transnational cinema through specific categories of cultural and societal mobilization, and the writing on crossover cinema, this work aims to enter into a dialogue with the respective authors and propose a less structured approach to transnational mobilization. To study such mobilizations and its complex forms, co-production ventures were used as case studies to highlight the efforts of early international joint endeavors, and more recently, those of outsourcing agencies, as being nodes for changing forms of international collaborations. By focusing on Italian-Indian coproduced films, this work situates co-production studies within the literature on transnational cinema, and unsettles fixed cinematic categories in favor of a more mobile and fluid paradigm. Hence, the term Liminal cinema is proposed to critically assess and emphasize the dynamics of the complex phenomenon of transnational cinema-in-motion.
Enabling normal psychophysical development in children with hemophilia: the choice for prophylaxis

Hemophilia A and B, the congenital deficiencies of coagulation factors VIII and IX, are characterized by recurrent joint and muscle bleeding episodes and progressive musculoskeletal damage (hemophilic arthropathy). Primary prophylaxis – that is, the regular infusion of factor concentrates after the first hemarthrosis and/or before 2 years of age – is now recognized as the first-choice treatment for children with severe hemophilia. Preventing bleeding from an early age enables avoidance of the clinical impact of hemophilic arthropathy and the consequences regarding psychosocial development and quality of life for these children. Interestingly, recent data suggest a role for early prophylaxis in also preventing inhibitor development, the most serious complication of treatment in hemophilia. Secondary prophylaxis, initiated after 2 years of age or after two or more joint bleeds, aims to avoid (or delay) the progression of arthropathy. In addition, better outcomes and better quality of life have been reported.
Efficient contactless heartbeat rate measurement for health monitoring

Motivations: Heartbeat Rate (HR) is an important physiological parameter required in health monitoring. Recent methods use videos captured by simple webcams to track subtle periodic changes of facial skin color for contactless HR measurement. These methods denoise the raw Heartbeat Signal (HS) and then transform the signal to frequency domain to measure the HR from the highest frequency component. However, simple denoising does not provide visible heartbeat peaks for analysis, and the highest frequency component does not always represent heartbeat. Thus, we propose a novel way for HS processing, which solves the aforementioned problems and provides a precise measurement of HR for health monitoring. Method: We, first, extract the HS from facial video by tracing the facial color changes. As heartbeats are cyclic, the HS is passed through a Hodrick–Prescott filter to reduce trends. The signal is then decomposed into some Intrinsic Mode Functions (IMF) by employing a Complete Ensemble EMD with Adaptive Noise (CEEMDAN) [1]. As the raw HS from facial video is composed of heartbeat and noise components, the decomposition generates an IMF that keeps the heartbeat peak in an uncontaminated form. We empirically select that IMF and employ a peak detection (local maxima) method to detect the number of heartbeat peaks in a time interval. The number of peaks provides us with the measurement of HR. Results and discussions: We tested a Matlab implementation of the system on the well-known MAHNOB-HCI database [2]. The database has 491 videos, each video longer than 30 seconds which are collected from 23 subjects in realistic scenarios. The proposed method obtained the Root Mean Square Error (RMSE) 8.54 bpm and Mean Error Rate (MER) 11.96% while comparing to the ground truth ECG. In addition, we compared the results of the proposed method with the state-of-the-art-methods proposed in [3]–[5]. The proposed approach outperformed these methods both by RMSE 5.06, 16.56 and 12.46 bpm and MER 1.24%, 11.30% and 8.11%, respectively. The results imply that the proposed method can provide a highly accurate (around 90%) system for HR measurement and can be effectively used for health care and monitoring application.
A Network Perspective of Value Co-Creation in Cross-Border Relationships: Changing from 'One of Them' to 'One of Us'

For SME exporters, developing an effective value co-creation strategy appears to be a good way to overcome resource constraints and other market structural barriers in internationalisation. As an emerging topic in the marketing literature, value co-creation is mainly studied in B2C markets, and the understandings of value co-creation are still quite fragmented and abstract with limited empirical investigations. Inspired by the recent development of the business network theory and S-D logic, my thesis presents a new theoretical framework for value co-creation in cross-border business relationships. Through an in-depth case study, this research confirms ten propositions in relation to the theoretical framework and identifies the most important motives, attributes and outcomes of value co-creation. Some insights in the case are unique to value co-creation, such as hierarchical resource integration. The findings in this research indicate that the co-creation of symbolic value and the emerging value co-creation network will benefit participating firms and also attract more firms to join. Compared with other types of business relationships, the uniqueness of value co-creation is the significant interplay of trust and resource integration. More importantly, this study shows the creation of a novel network, including both B2C and B2B markets, which is wider than the integration of the prior individual networks. Overall, this new value co-creation network is competitive and viable for SME exporters to overcome internationalisation barriers. It also shifts the network position from being ‘one of them’ to becoming ‘one of us’ in the eyes of local network incumbents in the export markets. This is the fundamental goal that a SME exporter may achieve in the export market, for the benefit of long-term survival and growth.
CHILDHOOD ADVERSITY AND ITS EFFECTS ON HEALTH OVER THE LIFESPAN: ANALYSIS OF THE ALLEGHENY COUNTY HEALTH SURVEY

It has been estimated that 75% of the U.S. adult population has experienced some type of childhood adversity (CA), such as child maltreatment, parental divorce or violence and evidence continues to mount that exposure to such adversities can lead to serious mental and physical health consequences that extend well into late life. The life course perspective (LCP) is a theoretical perspective often used to explain how early life exposures influence health and behavior across the lifespan. Using the LCP and secondary data collected from the 2009-2010 Allegheny County Health Survey (N=5442), this study describes the prevalence and disparities in CA in terms of social, demographic, and geographic characteristics. A series of bivariate and multivariate logistic regressions are conducted to determine which adult health indicators (e.g., smoking, perceived social support, serious mental illness, cancer, cardiovascular disease) are most associated with CA and to what extent the prevalence of these health issues could be reduced if CA was prevented or eliminated. Furthermore, social, behavioral, and environmental pathways are evaluated in statistical models to determine which factors moderate and mediate the relationship between CA and adult health and behavior. Results indicate that CA is prevalent in the adult population of Allegheny County, Pennsylvania with an estimated 59.8% reporting at least one adverse childhood event. CA disparities were observed by gender, race, socioeconomic status, unemployment status and disability status. Population Attributable Risk (PAR) fractions were calculated and revealed that approximately 42% of serious mental illness and 26% of cardiovascular disease in the population could be eliminated if ACEs were prevented. Social and behavioral factors that mediate the CA adult health relationships included adult socioeconomic status, social support, smoking, and body mass index. The effects of CA on adult health appeared stronger and more independent for mental health outcomes than physical health outcomes. For those at-risk of and those who have experiencing CA, programs and policies that increase resources, teach positive strategies for coping with stress, and help families to increase their human and social capital may greatly reduce adult morbidly associated with CA and help to reduce current and intergenerational CA disparities by race and socioeconomic status.