Miracle-dz/UniFAR-FTUs huggingface dataset:
The cause of arterial hypoxemia at rest in patients with "alveolarcapillary block syndrome".

Hypoxemia in patients with "alveolar-capillary block syndrome" is believed to be due to a barrier to the diffusion of oxygen caused by thickened alveolar and capillary membranes (1, 2). Theoretical considerations indicate that thickened membranes should not result in a Po2 difference between alveolar gas and pulmonary capillary blood when patients with impaired diffusion breathe 100 per cent 02. Inhalation of 02, therefore, should always correct hypoxemia in patients in whom a barrier to diffusion is the only defect. The reasoning is as follows: inhalation of 02 at sea level raises alveolar Po2 to about 670 mm Hg, and the large initial Po2 difference between alveolar gas and blood entering the pulmonary capillaries (600 to 630 mmHg) causes a rapid diffusion of 02 across even thickened alveolarcapillary membranes and prompt saturation of the hemoglobin (3, 4). After hemoglobin is saturated with 02, the 02 behaves like an inert gas and enters the blood only in physical solution and almost instantaneously, so that blood leaving the pulmonary capillaries is in equilibrium with the Po2 in the alveolar gas. Our original plan was to test this theory by measuring directly the arterial Po2 of patients with "pure" alveolar-capillary block syndrome while they were breathing pure 02. If the theory is correct (and if pulmonary artery-to-vein shunts are not increased in these patients) the arterial Po2 should equal that of healthy subjects breathing pure 02 (620 to 650 mmHg). On analysis of our data we realized that the arterial hypoxemia in patients with alveolar-capillary block syndrome
Quantification of interactions among circadian clock proteins via surface plasmon resonance

Circadian clock is an internal time keeping system recurring 24 h daily rhythm in physiology and behavior of organisms. Circadian clock contains transcription and translation feedback loop involving CLOCK/NPAS2, BMAL1, Cry1/2, and Per1/2. In common, heterodimer of CLOCK/NPAS2 and BMAL1 binds to EBOX element in the promoter of Per and Cry genes in order to activate their transcription. CRY and PER making heterodimeric complexes enter the nucleus in order to inhibit their own BMAL1‐CLOCK‐activated transcription. The aim of this study was to investigate and quantify real‐time binding affinities of clock proteins among each other on and off DNA modes using surface plasmon resonance. The pairwise interaction coefficients among clock proteins, as well as interaction of PER2, CRY2, and PER2 : CRY2 proteins with BMAL1 : CLOCK complex in the presence and absence of EBOX motif have been investigated via analysis of surface plasmon resonance data with pseudo first‐order reaction kinetics approximation and via nonlinear regression curve fitting. The results indicated that CRY2 and PER2, BMAL1, and CLOCK proteins form complexes in vitro and that PER2, CRY2 and PER2 : CRY2 complex have similar affinities toward BMAL1 : CLOCK complex. CRY2 protein had the highest affinity toward EBOX complex, whereas PER2 and CRY2 : PER2 complexes displayed low affinity toward EBOX complex. The quantification of the interaction between clock proteins is critical to understand the operation mechanism of the biological clock and to address the behavioral and physiological disorders, and it will be useful for the design of new drugs toward clock‐related diseases. Copyright © 2014 John Wiley & Sons, Ltd.
Selected Clinical Features and Service Characteristics of Autistic Adults

314 autistic adults were identified as part of an over-all statewide needs assessment of developmentally disabled persons. Most of the adults were mentally retarded, but generally free from physical or sensory disabilities. Manifold language and adaptive skill deficits were noted. Some 59% resided in an institutional setting; the balance were at home or in a community-care setting. Comments underscored difficulties in case finding and the need to anticipate the adult needs of autistic children.
Joint mobility and the oscillation characteristics of muscle

The aim of this study was to investigate which muscle characteristics of oscillation of the lower extremities have influence on trunk forward flexion and knee extension. The frequency and the decrement of damped oscillation of the muscles m. rectus femoris, m. biceps femoris, m. semitendinosus and t. semimembranosus in relaxed, contracted or stretched states were recorded by the myometer among the 22 first‐year male students of the department of physical education. The subjects were divided twice into two groups according to: 1) the values of the trunk forward flexion, and 2) the values of the knee extension range of motion. The oscillation frequency of m. rectus femoris of the groups with high trunk forward flexion and high knee extension range of motion was lower than in groups with less range of motion. The similarity was followed in the decrement of m. semitendinosus. The difference between the decrements of the relaxed and stretched state of m. semitendinosus and the decrement of the relaxed state of the same muscle tendon correlated with the knee extension range of motion (r=0.46 and r=0.48, P<0.05). The relationship between the decrement of the relaxed state of m. biceps femons and the range of motion was r=‐0.51 (P<0.01). The results of this study showed that the characteristics of the damped oscillation as indirect parameters of viscoelastic properties of the muscles were related to the joint mobility.
Arterial Ischemic Stroke in Childhood: Risk Factors and Outcome in Old Versus New Era

Risk factors of children with arterial ischemic stroke were retrospectively evaluated. The children were grouped according to values on developing diagnostic tools: 13 in the old era (1987-1994) and 18 in the new era (1995-2004). The old era battery included 5 tests: protein C, protein S, antithrombin, lupus anticoagulants, and anticardiolipin antibodies. The new era battery added 5 more tests: homocystine level, factor VIII level, mutations for factor V Leiden and prothrombin G20210A, and lipoprotein (a) level. At least 1 risk factor was found in 5 of 13 children (38.5%) in the old era and in 8 of 18 (44.4%) in the new era. The extended battery for prothrombotic disorders revealed 7 risk factors in 4 children (22.2%) in the new era, whereas the limited battery identified a single risk factor in 1 child (7.7%) in the old era. For the correct etiologic identification, prothrombotic risk factors should be extensively evaluated in patients with arterial ischemic stroke.
Taking advantage of load voltage sensitivity to stabilize power system frequency

This paper analyzes the provision of a new dynamic frequency support to isolated power systems using a fast control of the load through the grid voltage. This control has appealing advantages, among which: 1) no impact on customers provided that their voltage remains within admissible limits, 2) the only communication that is required is the grid voltage itself and 3) the response is almost instantaneous. The possible solutions for implementing such a concept in practice are reviewed, and a shortlist of selected options is characterized using dynamic simulations. The results show that it is possible to take advantage of load voltage sensitivity to improve the transient behavior of isolated power systems following major outages. The proposed control can be put in place by adding a new feature to the voltage regulators of conventional generation assets.
Mapping QTL for Heat-Tolerance at Grain Filling Stage in Rice

A mapping population of 98 lines (backcross inbred lines, BILs) derived from a backcross of Nipponbare/Kasalath// Nipponbare was planted at two experimental sites, Nanjing and Nanchang, and treated with high and optimal temperature during grain filling, respectively. The grain weight heat susceptibility index (GWHSI= (grain weight at optimum temperature-grain weight at high temperature) / grain weight at optimum temperature×100) was employed to evaluate the tolerance of rice to heat stress. A genetic linkage map with 245 RFLP markers and a mixed linear-model approach was used to detect quantitative trait loci (QTLs) and their main effects, epistatic interactions and QTL×environment interactions (Q×E). The threshold of LOD score=2.0 was used to detect the significance of association between marker and trait. A total of 3 QTLs controlling heat tolerance during grain filling were detected, on chromosomes 1, 4 and 7, with LOD scores of 8.16, 11.08 and 12.86, respectively, and they explained the phenotypic variance of 8.94, 17.25 and 13.50 %, correspondingly. The QTL located in the C1100-R1783 region of chromosome 4 showed no QTL×environment interaction and epistatic effect, suggesting that it could be stably expressed in different environments and genetic backgrounds, and thus it would be valuable in rice breeding for heat tolerance improvement. This QTL allele, derived from Kasalath reduced 3.31% of the grain weight loss under heat stress. One located between R1613-C970 on chromosome 1 and the other between C1226-R1440 on chromosome 7, with additive effect 2.38 and 2.92%, respectively. The tolerance alleles of both these QTLs were derived from Nipponbare. Both of these QTLs had significant QTL×environment interactions, and the latter was involved in epistatic interaction also. Eight pairs of epistatic effect QTLs were detected, one pair each on chromosomes 1, 2, 3, 5, 7, 8, 10 and 12. The results could be useful for elucidating the genetic mechanism of heat-tolerance and the development of new rice
“RAPID” Team Triage: One Hospital's Approach to Patient-Centered Team Triage

Patients who present to the emergency department want definitive care by a health care provider who can perform an initial assessment, initiate treatment, and implement a disposition plan. The traditional “nurse triage” model often creates barriers to the process of rapidly evaluating patients. Therefore, innovative strategies must be explored to improve the time of patient arrival to the time seen by a qualified provider in order to complete a thorough medical screening examination. One such approach is a rapid team triage system that provides a patient-centered process. This article describes the implementation of a rapid team triage model in an urban community hospital.
In pursuit of a missing transition: the Mesolithic and Neolithic radiocarbon chronology at La Font-aux-Pigeons rockshelter

Abstract The 1950s excavations at Châteauneuf-lès-Martigues—type site of the Late Mesolithic Castelnovian phase—played a significant role in shaping theories about the nature of the Neolithic transition in the western Mediterranean. Results of new AMS dating and Bayesian modelling of extant short life samples now date the Late Mesolithic deposits to c. 6460–6200 cal BC, and the Cardial deposits to c. 5260–4860 cal BC. The long gap within the stratigraphic sequence is interpreted as a consequence of erosion during the mid sixth millennium BC. These results overturn the older argument for Mesolithic–Neolithic continuity at this key site.
A cognitive linguistic approach to the emotion of anger in the Old Testament

This article reviews several approaches to the study of anger in the Old Testament. It focuses on the use of methodology in these trends with specific reference to the common neglect of Classical Hebrew terminology and expressions relating to the emotion of anger. Such styles lead to an impoverished understanding of the ideal cognitive model of anger as reflected in Classical Hebrew. By contrast, the few recent cognitive linguistic studies on the same subject prove to be far more successful in giving a detailed account of the ancient Israelite conceptualisation of this emotion.
Induction by arsenate of cell-type-specific cytotoxic effects in nerve and hepatoma cells

The aim of the study was to compare the effect of sodium arsenate (AsV) on two different cell types: 158N murine oligodendrocytes and HepG2 human hepatoma cells. Exposure of 158N cells to AsV (0.1–400 µM; 48 h) induced a biphasic cytoxic effect defined as hormesis. Thus, low concentrations of AsV stimulate cell proliferation, as shown by phase-contrast microscopy, cell counting with trypan blue, and crystal violet assay, whereas high concentrations induce cell death associated with a loss of cell adhesion. These side effects were confirmed by staining with propidium iodide and cell cycle analysis, characterized by the presence of a subG1 peak, a criterion of apoptosis. The effects of AsV on mitochondrial function, as determined by the 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium (MTT) assay, the measurement of mitochondrial transmembrane potential with 3,3′-dihexyloxacarbocyanine iodide, and the rate of mitochondrial adenosine triphosphate confirm the impact of AsV on the mitochondria. In contrast to 158N cells, HepG2 cells were susceptible to all AsV concentrations as shown by microscopic observations, by counting with trypan blue. However, no alteration is noted in the cell membrane integrity, which indicated an apoptotic mode of cell death, and this side effect is confirmed by the cycle analysis, which revealed a subG1 peak. Of note, there was a loss of MTT, suggesting that AsV induces mitochondrial complex II dysfunction. Altogether, our data show that the cytotoxic characteristics of AsV depend on the cell type considered.
Effects of active alert and relaxation hypnotic inductions on cold pressor pain.

We contrasted relaxation and active alert hypnotic inductions with or without a specific suggestion for cold pressor pain analgesia. Groups of high (n = 38) and low (n = 27) hypnotizable subjects were tested; hypnotizability had been determined from results of the Stanford Hypnotic Susceptibility Scale, Form C. Cold pressor pain data were obtained after counterbalanced exposure to relaxation and active alert inductions. Highly hypnotizable subjects demonstrated lower pain scores than did low hypnotizable ones. Pain reports did not differ between induction conditions. Highly hypnotizable subjects given an analgesic suggestion showed lower pain scores than did those exposed only to hypnosis. The findings, conceptualized within E.R. Hilgard's (1977a) neodissociation theory, show that relaxation is not necessary for hypnotic analgesia.
Recognition of Staphylococcus aureus by the Innate Immune System

SUMMARY The gram-positive bacterium Staphylococcus aureus is a major pathogen responsible for a variety of diseases ranging from minor skin infections to life-threatening conditions such as sepsis. Cell wall-associated and secreted proteins (e.g., protein A, hemolysins, and phenol-soluble modulin) and cell wall components (e.g., peptidoglycan and alanylated lipoteichoic acid) have been shown to be inflammatory, and these staphylococcal components may contribute to sepsis. On the host side, many host factors have been implicated in the innate detection of staphylococcal components. One class of pattern recognition molecules, Toll-like receptor 2, has been shown to function as the transmembrane component involved in the detection of staphylococcal lipoteichoic acid and phenol-soluble modulin and is involved in the synthesis of inflammatory cytokines by monocytes/macrophages in response to these components. Nod2 (nucleotide-binding oligomerization domain 2) is the intracellular sensor for muramyl dipeptide, the minimal bioactive structure of peptidoglycan, and it may contribute to the innate immune defense against S. aureus. The staphylococcal virulence factor protein A was recently shown to interact directly with tumor necrosis factor receptor 1 in airway epithelium and to reproduce the effects of tumor necrosis factor alpha. Finally, peptidoglycan recognition protein L is an amidase that inactivates the proinflammatory activities of peptidoglycan. However, peptidoglycan recognition protein L probably plays a minor role in the innate immune response to S. aureus. Thus, several innate immunity receptors may be implicated in host defense against S. aureus.
Outcome of Tongue-Lip Plication in Patients with Severe Pierre Robin Sequence

Pierre Robin sequence is classically defined as the triad of micrognathia, glossoptosis, and respiratory distress, with most infants (60%– 90%) also having cleft palate. Infants frequently have feeding and respiratory difficulties from posterior displacement of the tongue in the setting of mandibular hypoplasia. Initially, infants can be managed by placement in the prone position and use of gastric lavage feeding tubes. Pasyayan and Lewis reported good results for 25 Pierre Robin sequence patients managed with these conservative measures only. If the infant does not improve with positioning, an oral airway or nasopharyngeal intubation may relieve the distress. In cases of severe respiratory distress or failure to thrive despite these conservative measures, surgical intervention is necessary to relieve obstruction. Tracheostomy can definitively restore the airway but is not without significant morbidity, including hemorrhage, pneumothorax, fistula, tracheitis, and difficulty in decannulation. Recently, mandibular distraction osteogenesis has been advocated as a means to improve airway obstruction and avert tracheostomy. This procedure is rather involved, however, and entails demanding postoperative care. The long-term effects of mandibular distraction on growth and dental development are unknown at this time. Beverly Douglas first proposed glossopexy as a means of relieving airway obstruction in Pierre Robin sequence. This procedure remains a subject of debate, with favorable results countered by reports of complications, including dehiscence, infection, submaxillary duct obstruction, and lip scarring. In this study, we review our experience with tonguelip plication surgery over a 15-year period to determine its clinical usefulness. MATERIALS AND METHODS
[An overview of snow-boarding injuries].

Snowboarding is increasing dramatically in popularity in Switzerland as well as other countries. Work aimed at improving the design of the boards and of the boots and bindings has also increased rapidly during recent years. Most injured snowboarders are fit young men and boys who describe themselves as beginners and have had a minimal amount of instruction at an officially approved training centre. Appropriate snowboard training has mostly been quite inadequate, and protective devices (e.g. waterproofed support gloves). The anatomical distribution and the types of injuries sustained in snowboarding differ from those in alpine skiing. The wrist (and forearm) and the ankle are the most frequent locations of injuries (23%) as against the knee and thumb in alpine skiing. Sprains and strains were the most frequent types of injuries (46%), followed by fractures (28%) and contusions (13.5%). The snowboard injury rate was higher than in alpine skiing (1.7-8/1000 snowboard days versus 2-4/1000 ski days). Falling forward on the slope was the major mechanism of injury (80%), and torsion the next most frequent (20%). Snowboarding injuries were sustained most often on ice and hardpacked snow, compared with soft powder snow for alpine skiing injuries. Appropriate preseason conditioning, snowboarding lessons from a certified instructor, appropriate selection of rigorously tested equipment and use of protective devices are the main steps that must be taken to prevent injuries.
The ultrasonic characteristics of the renal pelvicalyceal echo complex

The pelvicalyceal echo complex has a characteristic appearance as an echo‐filled cylinder in which minimal sonolucency may normally be seen. Alteration in the pelvicalyceal echo complex is a helpful guide in the diagnosis of a variety of pathological processes involving the kidneys. Reliable diagnosis of moderate and marked hydronephrosis may be made by the appearance of uniformly sized, sonolucent collections in the pelvicalyceal echo complex which show communication with the renal pelvis. An adjacent simple renal cyst produces a sharply defined crescent shaped deformity of the pelvicalyceal echo complex, and scalloping is seen with multiple impinging renal cysts. Gross deformity of the central echo complex is seen with polycystic kidney disease, as well as in neoplasia. Edema and infiltrating hypernephroma may result in diminution of the pelvicalyceal echo complex. Amputation or a “V”‐shaped splitting of the pelvicalyceal echo complex may be seen with neoplasia.
Does Agritourism Enhance Farm Profitability

The impacts of agritourism on farm profitability are poorly understood. Using Census of Agriculture records, we employ propensity score matching to estimate the effects of agritourism on the net cash income per acre of New Jersey farms. We find that agritourism has statistically significant and positive effects on farm profitability. Profit impacts are highest among small farms operated by individuals primarily engaged in farming. Positive but smaller effects are observed for lifestyle farms. Profit effects among larger farms are not statistically significant.
TRANSFERRIN RECEPTOR-MEDIATED GENE TRANSFER TO THE CORNEAL ENDOTHELIUM1

Background. The application of gene therapy to prevent allograft rejection requires the development of noninflammatory vectors. We have therefore investigated the use of a nonviral system, transferrin-mediated lipofection, to transfer genes into the cornea with the aim of preventing corneal graft rejection. Methods. Rabbit and human corneas were cultured ex vivo and transfected with either lipofection alone or in conjunction with transferrin. The efficiency of transfection, localization, and kinetics of marker gene expression were determined. Strategies to increase gene expression, using chloroquine and EDTA, were investigated. In addition to a marker gene, a gene construct encoding viral interleukin 10 (vIL-10) was transfected and its functional effects were examined in vitro. Results. Transferrin, liposome, and DNA were demonstrated to interact with each other, forming a complex. This complex was found to deliver genes selectively to the endothelium of corneas resulting in gene expression. Treatment of corneas with chloroquine and EDTA increased the transfection efficiency eightfold and threefold, respectively. We also demonstrated that constructs encoding vIL-10 could be delivered to the endothelium. Secreted vIL-10 was shown to be functionally active by inhibition of a mixed lymphocyte reaction. Conclusions. Our data indicate that transferrin-mediated lipofection is a comparatively efficient nonviral method for delivering genes to the corneal endothelium. Its potential for use in preventing graft rejection is shown by the ability of this system to induce vIL-10 expression at secreted levels high enough to be functional.
Content Aware Music Analysis with Multi-Dimensional Similarity Measure

Music players and cloud solution for music recommendation and automatic playlist creation are becoming increasingly more popular, as they intent to overcome the issue of the difficulty for users to find fitting music, based on context, mood and impression. Much research on the topic has been conducted, which has recommended different approaches to overcome this problem. This paper suggests a system which uses a multi-dimensional vector space, based on the music’s key elements, as well as the mood expressed through them and the song lyrics, which allows for difference and similarity finding to automatically generate a contextually meaningful playlist.