Miracle-dz/UniFAR-FTUs huggingface dataset:
Quantifying swallowing function after stroke: A functional dysphagia scale based on videofluoroscopic studies.

OBJECTIVE To develop a sensitive, specific scale for quantifying functional dysphagia in stroke patients, using results obtained from videofluoroscopic swallowing studies. DESIGN Data collected from a serial oral and pharyngeal videofluoroscopic swallowing study. SETTING A dysphagia clinic in a department of rehabilitation medicine at a tertiary care university hospital. PARTICIPANTS One hundred three consecutively admitted stroke patients. INTERVENTIONS Videoflurorscopy to measure a scale of 11 variables: lip closure score, bolus formation, residue in oral cavity, oral transit time, triggering of pharyngeal swallow, laryngeal elevation and epiglottic closure, nasal penetration, residue in valleculae, coating of pharyngeal wall after swallow, and pharyngeal transit time. MAIN OUTCOME MEASURES Polychotomous linear logistic regression analysis of videofluoroscopic and aspiration results. Scale sensitivity and specificity, and the correlation between the total score of the scale and aspiration grade were analyzed. RESULTS The scale's sensitivity and specificity for detecting supraglottic penetration and subglottic aspiration were 81%, 70.7%, and 78.1%, 77.9%, respectively. A significant positive correlation was found between the scale's total score and the severity of aspiration (Spearman's r =.58943, p =.00001). CONCLUSION This functional dysphagia scale, which was based on a videofluoroscopic swallowing study in stroke patients, is a sensitive and specific method for quantifying the severity of dysphagia.
Improving LTE throughput with iterative water-filling algorithm

The frequency spectrum is an expensive and limited resource while the massive demand of telecommunication services both of data and number of connection continue to raise. The ordinary network becomes denser to meet the growing needs of the services. It can be done by introducing more cells in the network, with lower coverage than the ones that already exist or simply by splitting the existing cell, to allows a better spatial reuse of the spectrum. However, the introduction of more cells also leads to high-interference between cells (low values of Signal to Interference and Noise Ratios (SINRs)). In order to maximize the use of spectrum, it is necessary to study that behaviour and help to mitigate the interference. The research presented here focus on the use of the iterative water-filling algorithm to improve network cell throughput in LTE network. In the context of spectrum management, iterative water-filling is a technique to adjust power as needed according to the conditions in the environment of interference. The results show that the proposed method can increase the overall cell throughput about 7.56% and average UE throughput 9.53%.
An Organizational Perspective on Patenting and Partnering: Unpacking Capacities to Manage Participation in Patent Pools

In this research, we investigate how firms manage their participation in patent pools, which are private interorganizational arrangements for sharing patents on a large scale. Drawing on the licensing and open innovation literature, we develop a conceptual framework to analyze the organizational capacities that enable firms to manage their participation in patent pools. We illustrate and enrich this conceptual framework through an in‐depth study of Technicolor. Our findings show that the company develops and leverages its patent portfolio to strengthen its positions both as a licensee and licensor vis‐a‐vis the pools' members through two articulated capacities: absorptive and desorptive. We also reveal how the company assesses opportunities to join patent pools and continues to integrate more patents. The organizational perspective articulated in this paper enhances the understanding of patent pools and expands the literature on licensing and open innovation.
Susceptibility and Resilience to Memory Aging Stereotypes: Education Matters More than Age

The authors examined whether the memory performance of young, middle-aged, and older adults would be influenced by stereotype versus counterstereotype information about age differences on a memory task. One hundred forty-nine adults from a probability sample were randomly assigned to a control group or to age-stereotype conditions. As predicted, counterstereotype information was related to higher recall compared to stereotype and control groups. This was true across all age groups, but only for those with more education. Both stereotype and counterstereotype information were related to lower recall compared to the control group across age groups for those with lower education. Results suggest those with more education are more resilient when faced with negative age stereotypes about memory and respond positively to counterstereotype information. In contrast, those with less education show greater susceptibility to the detrimental effects of age stereotypes and respond negatively to both stereotype and counterstereotype information about memory aging.
The molecular basis of alpha-thalassemia in Thailand.

Alpha thalassemia is the most common single gene mutation worldwide. In Thailand there exists 15-30% alpha-thalassemia carriers distributed throughout the country. DNA analysis by Southern blot hybridization reveals that the two major alpha-thalassemia alleles, alpha-thalassemia 1 and alpha-thalassemia 2 have different extents of alpha-globin gene deletion. In alpha-thalassemia 1, approximately 20 kb of DNA including the two linked alpha 1-and alpha 2-genes are removed and only the alpha-globin gene is intact. Total deletion of the alpha-globin gene cluster is rarely observed. In contrast, only one alpha-globin gene is deleted in alpha-thalassemia 2 of which two types have been detected, one involving a deletion of 4.2 kb of DNA (leftward type, -alpha 4.2) and another of 3.7 kb (rightward type, -alpha 3.7); the latter being more common than the former in Thailand. Compound heterozygosity for alpha-thalassemia 1 and alpha-thalassemia 2 results in HbH disease while homozygosity for alpha-thalassemia 1 leads to Hb Bart's hydrops fetalis, the most severe form of thalassemic disease. Three alpha-thalassemic hemoglobinopathies have been detected in Thailand, two of which produce a remarkable reduction in gene product. Upon interacting with alpha-thalassemia 1 gene they can lead to HbH disease. The most common in this group is Hb Constant Spring which arises from mutation of the termination codon in the alpha 2-gene resulting in an elongation of the alpha-globin chain. (ABSTRACT TRUNCATED AT 250 WORDS)
Job Mismatch and On‐the‐job Search Behavior Among University Graduates in Malaysia

This paper examines the incidence and the effects of job mismatch on workers' job search behavior while working in Malaysia. Using the 2007 Graduate Tracer Study (GTSâ€ 07) dataset, approximately 32 percent of workers were deemed mismatched and 52 percent were actively looking for another job. Using a logit model, the risk of being engaged in onâ€ theâ€ job search activity was higher among the mismatched workers and the magnitude of the effects was greater for the severely mismatched than for the moderately mismatched workers. This suggests that the mismatched workers are heterogeneous. This might be due to different traits of workers or there may be unobserved heterogeneity that varies from one mismatched to another mismatched worker.
Familial Aggregation of Nonhematological Malignancies in Relatives of Patients with Hematological Neoplasms

Familial aggregation of nonhematological malignant disorders (NHMD) was compared in 189 families of patients with hematological neoplasms (HN) with a control group of 36 families of patients with benign hematological disorders and a second group of 33 families of patients with diabetes mellitus. A self-administered questionnaire was used requesting from each family a full list of first- and second-degree relatives, their vital status, current age or age at death, and a list of their chronic diseases, including all malignant disorders. There was no evidence of a significantly increased tendency for developing NHMD among relatives of patients with HN as compared to controls (adjusted odds ratio of 0.88; 95% confidence interval 0.61–1.27). Moreover, in the HN group, no significant difference in the frequency of NHMD was found between the families with and without familial aggregation of HN. Based on the present analysis and our previous observations on familial aggregation of HN, we conclude that the increased aggregation of malignant disorders among relatives of patients with HN is unique to the hematopoietic system and might result from a genetic predisposition to HN in these families.
Prognostic significance of sympathetic nervous system activation in pulmonary arterial hypertension.

RATIONALE The sympathetic nervous system has been reported to be activated in pulmonary arterial hypertension (PAH). OBJECTIVES We investigated the prognostic significance of muscle sympathetic nervous system activity (MSNA) in PAH. METHODS Thirty-two patients with PAH were included in the study and underwent a measurement of MSNA over a 6-year period of time. They had undergone a concomitant evaluation of New York Heart Association (NYHA) functional class, a 6-minute walk distance (6MWD), an echocardiographic examination, and a right heart catheterization for diagnostic or reevaluation purposes. The median follow-up time was 20.6 months (interquartile range, 45.8 mo). Clinical deterioration was defined by listing for transplantation or death. MEASUREMENTS AND MAIN RESULTS Seventeen patients presented with clinical deterioration. As compared with the 15 others, they had an increased MSNA (80 +/- 12 vs. 52 +/- 18 bursts/min; P < 0.001) and heart rate (88 +/- 17 vs. 74 +/- 12 bpm; P = 0.01), a lower 6MWD (324 +/- 119 vs. 434 +/- 88 m; P < 0.01) and a deteriorated NYHA functional class (3.6 +/- 0.5 vs. 2.9 +/- 0.8; P < 0.001). The hemodynamic variables were not different. MSNA was directly related to heart rate and inversely to 6MWD. A univariate analysis revealed that increased MSNA and heart rate, NYHA class IV, lower 6MWD, and pericardial effusion were associated with subsequent clinical deterioration. A multivariate analysis showed that MSNA was an independent predictor of clinical deterioration. For every increase of 1 burst/minute, the risk of clinical deterioration during follow-up increased by 6%. CONCLUSIONS Sympathetic nervous system activation is an independent predictor of clinical deterioration in pulmonary arterial hypertension.
DNA transcription and repressor binding affect deletion formation in Escherichia coli plasmids.

Chimeric plasmids containing phage M13 and plasmid pBR322 sequences undergo deletions in Escherichia coli with a high frequency. In all plasmids one deletion endpoint is the M13 replication origin nick site. We examined the effects of transcription on the position of the other deletion end‐point, by inserting in the plasmids an inducible promoter followed by a transcription terminator. Transcription dramatically affected deletions in an orientation‐dependent way, such that greater than 95% of end‐points were localized downstream from the inserted promoter when it faced the major plasmid transcripts. The end‐points were not constrained to the transcribed region and were not affected by the orientation of pBR322 DNA replication. We propose that deletion events occur preferentially in a plasmid domain which is rendered positively supercoiled by convergent transcription. We also show that interaction of LacI repressor with the cognate operator generates a localized deletion hot spot. This hot spot is dependent on pBR322 replication, and therefore probably acts by arresting progression of DNA replication.
In vivo cranial suture function and suture morphology in the extant fish Polypterus: implications for inferring skull function in living and fossil fish

SUMMARY This study describes the mechanical role that cranial sutures play in fish during feeding. The long-term goal of our work is to establish relationships between suture form and function, so that functional inferences can be made from suture morphology in fossil taxa. To this end, strain gauges were surgically implanted across selected sutures in the skull roof of four individuals of Polypterus endlicherii. After surgery, bone and suture strains during feeding were recorded along with high-speed video of the feeding events. Each trial was designated as a suction feeding or biting on prey trial, and neurocranial elevation, hyoid position and gape were quantified to aid in interpreting the strain data. The strains due to suction feeding are different from those observed during biting. Suction feeding results in a fairly stereotyped strain pattern, with the interfrontal and frontoparietal sutures experiencing tension, while the interparietal suture is compressed. Biting causes much more variable strain patterns. However, both suction and biting result in compression in the back of the skull, and tension between the frontals. Peak strains, and the time at which they occur in the feeding cycle, were compared between suction and biting. In general, peak suture strains are higher during suction than during biting, but not all of these differences are significant. Peak suture and bone strains occur at or near maximum gape during both suction and biting, suggesting that these strains are caused by muscle contraction involved in mouth opening and closing. Micro-computed tomography (microCT) scans of the experimental specimens indicate that the interfrontal and frontoparietal sutures, typically loaded in tension, are less interdigitated in cross section than the interparietal suture, which experiences compression. This is consistent with published correlations of suture form and function in mammals, where interdigitated sutures indicate compression and lack of interdigitation is associated with tension.
The Consequences of Uncertainty: Climate Sensitivity and Economic Sensitivity to the Climate

We construct an integrated assessment model with multiple energy sources—two fossil fuels and green energy—and use it to evaluate ranges of plausible estimates for the climate sensitivity, as well as for the sensitivity of the economy to climate change. Rather than focusing explicitly on uncertainty, we look at extreme scenarios defined by the upper and lower limits given in available studies in the literature. We compare optimal policy with laissez faire, and we point out the possible policy errors that could arise. By far the largest policy error arises when the climate policy is overly passive; overly zealous climate policy (i.e., a high carbon tax applied when climate change and its negative impacts on the economy are very limited) does not hurt the economy much as there is considerable substitutability between fossil and nonfossil energy sources.
Increased Thyroid‐Stimulating Hormone Levels Associated with Concomitant Administration of Levothyroxine and Raloxifene

A 47‐year‐old Caucasian woman had a 3.5‐year history of primary hypothyroidism treated with levothyroxine. Her levothyroxine dosage of 0.05 mg/day had been stable for the past 15 months. She was then prescribed raloxifene for prevention of osteoporosis secondary to early menopause. During the next 30 months, her levothyroxine dosage had to be gradually increased. The patient had been taking levothyroxine and raloxifene at the same time each day on an empty stomach. During the months of her levothyroxine dosage changes, however, she separated administration of levothyroxine and raloxifene by 12 hours; the patient then became hyperthyroid. Eventually, her levothyroxine needs decreased, and she returned to the same levothyroxine dosage she had taken before separating administration of the two drugs. These findings suggest that raloxifene decreased the absorption of levothyroxine when the two agents were coadministered. Assessment of causality using the Naranjo adverse drug reaction probability scale resulted in a possible association for this adverse event. Another published case report provides findings similar to our patient's experience. The possibility of a malabsorption interaction between levothyroxine and raloxifene is significant, as hypothyroidism is common among postmenopausal women—the same population that is the target of osteoporosis therapy with agents such as raloxifene. The mechanism by which raloxifene decreases levothyroxine absorption is unknown. Further investigation of this potential interaction is warranted. Until then, clinicians should be alert to the potential for an interaction between raloxifene and levothyroxine.
Pushing the scaling limits of embedded non-volatile memories with high-K materials

In this paper, two alternative cell concepts to overcome these issues were discussed: conventional floating gate cells with high-K inter-poly dielectrics (IPD) and nitride trapping devices with high-K materials. In both concepts, the reduced equivalent oxide thickness (EOT) of the high-K layers helps reducing VPE, whereas the low leakage current ensures a good data retention. In this work, only hafnium based high-K materials were used: hafnium oxide (HfO2) and nitrided hafnium silicate (HfSiON), both deposited by MOCVD. The choice for these materials was based on their expected availability in the sub-45nm CMOS nodes
A modified surgical technique for root coverage with an allograft: a 12-month randomized clinical trial.

BACKGROUND The aim of this randomized controlled clinical study is to investigate whether a modified surgical technique could provide better results for root coverage and greater amounts of keratinized tissue (KT) with the acellular dermal matrix graft (ADMG). METHODS Fifteen bilateral Miller Class I or II gingival recessions (GRs) were selected. The recessions were treated and assigned randomly to the test group (TG), and the contralateral recessions were assigned to the control group (CG). The ADMG was used in both groups with differences in the graft positioning between them. The following clinical parameters were measured before the surgeries and after 12 months: 1) probing depth; 2) relative clinical attachment level; 3) GR; 4) thickness of KT (TKT); and 5) KT width. A new parameter, the GR area (GRA), was measured in standardized photographs using a special device and software. RESULTS There was no significant difference between groups in KT width and TKT parameters at the 12-month postoperative period. However, there was a significant difference between the gains in GR (ΔGR) and GRA (ΔGRA), favoring the TG after 12 months. The TG presented ΔGR = 3.04 ± 0.29 mm and ΔGRA= 38,919 ± 9,238 pixel square values (pix(2)), and the CG presented ΔGR= 2.61 ± 0.41 mm and ΔGRA= 22,245 ± 9,334 pix(2) (P <0.05 and <0.001, respectively). CONCLUSIONS Both techniques were successful. The TG treatment was more effective in reducing GR and GRA. The flap and graft position may be of importance in root coverage procedures outcome.
Stochastic dynamics of the nerve growth cone and its microtubules during neurite outgrowth

The controlled extension of neurites is essential not only for nervous system development, but also for effective nerve regeneration after injury. This process is critically dependent on microtubule assembly since axons fail to elongate in the presence of drugs which disrupt normal assembly dynamics. For this reason, neurite outgrowth is potentially controllable by manipulation of the assembly state of the intracellular array of microtubules. Therefore, understanding how microtubule assembly dynamics and neurite outgrowth are coupled, in the absence of drugs, can lend valuable insight into the control and guidance of the outgrowth process. In the present study we characterized the stochastic dynamics of neurite outgrowth and its corresponding microtubule array, which advances concomitantly with the advance of the nerve growth cone, the highly motile structure at the terminus of the growing neurite, using reported fluorescent microscopic image sequences (Tanaka and Kirschner, 1991, J. Cell Biol. 115:345–363). Although previously modeled as an uncorrelated random walk, the stochastic advance of the growth cone was found to be anticorrelated over a time scale of ∼4 min, meaning that growth cone advances tended to be followed by growth cone retractions ∼4 min later. The observed anticorrelation most likely reflects the periodic stops and starts of neurite outgrowth that have been reported anecdotally. A strikingly similar pattern of anticorrelation was also identified in the advance of the growth cone's microtubule array. Cross‐correlation analysis showed that growth cone dynamics tended to precede microtubule dynamics on a time scale of ∼0–2 min, while microtubules tended to precede growth cone dynamics on a ∼0–20‐s time scale, indicating a close temporal coupling between microtubule and growth cone dynamics. Finally, the scaling of the mean‐squared displacements with time for both the growth cone and microtubules suggested a fractional Brownian motion model which accounts for the observed anticorrelation of growth cone and microtubule advance. © 1996 John Wiley & Sons, Inc.
The importance of quality management for the effectiveness of environmental management: evidence from companies located in Brazil

Recent discussions in the specialised literature support that quality management influences the level and maturity of environmental management practices; however, in searches performed in the ISI Web of Science and Scopus databases, it was verified that there is a need for research to portray this relationship quantitatively, especially when it comes to companies located in Brazil. Thus, this research aims to explore this gap: does quality management positively influence the adoption of environmental practices in companies located in Brazil? Therefore, a conceptual grounding on the aforementioned issues was carried out and, based on this, the questionnaire used for the empirical phase of the research was constructed, being a self-administered e-survey with 104 companies of all sizes and sectors located in Brazil. The results demonstrated that, in fact, quality management positively influences environmental management practices. In addition, it was verified that the size of the companies and ISO 14001 certification are significant to control environmental management practices. To date, it is believed that this is the first study that shows a survey to test the relationship between quality management and environmental management practices in companies in Brazil.