Miracle-dz/UniFAR-FTUs huggingface dataset:
Oral Academic Discourse Socialization of an ESL Chinese Student: Cohesive Device Use

Framed in language socialization theory, this study examines the longitudinal cohesive device development of an ESL Chinese graduate student over time during his discourse socialization by focusing on his oral presentations through a systemic functional linguistics approach. The study found that the participant improved in his use of textual resources as he continued his discourse socialization in the academic community that he had joined. Yet the problems and challenges the participant faced during his development of cohesive devices also illustrated the complexity and non-linear characteristics of academic discourse socialization. The study contributes to language socialization research by employing a systemic functional linguistics approach as an analysis tool for longitudinal linguistic discourse development. The findings inform second language curriculum and instruction, particularly oral language instruction.
Changes in the connective tissue of corpus and cervix uteri during ripening and labour in term pregnancy

The composition of the connective tissue of human cervix and corpus uteri was studied in tissue specimens from seven nonpregnant women and 14 pregnant women, delivered at term by section, to examine spontaneous cervical ripening and labour‐induced changes in both the uterine and the cervical connective tissue. The main finding in both the cervix and the corpus was a large (40–60%) decrease of the collagen concentration. The collagen extractability, obtained by pepsin digestion, was increased twofold, suggesting a change of the organization of the collagen fibrils. This reorganization process could also be demonstrated by a large increase of the collagenolytic activity demonstrated with an artificial DNP‐peptide substrate. The concentrations of sulphated glycosaminoglycans was lower in pregnant women than in non‐pregnant women. The results show that both the cervix and the corpus uteri contain substantial amounts of connective tissue components (collagen, sulphated glycosaminoglycans and hyaluronic acid) and that during ripening, reconstruction of the connective tissue components occurs in both sites. This indicates that the cervical state reflects that of the myometrium.
Chlamydiae and Atherosclerosis: Can Psittacine Cases Support the Link?

Abstract Atherosclerosis is a common disease in pet birds, particularly in psittacines. Little is known about the role of risk factors predisposing birds to this disease. In our study, we tried to detect chlamydiae in formalin-fixed and paraffin-embedded atherosclerotic tissue from 103 pet birds to clarify their role in atherosclerosis. Methods used were polymerase chain reaction (PCR), sequencing, and immunohistochemistry. Histopathologic examination served to classify the extent of atherosclerotic lesions. In the PCR, 4 (3.9%) of 103 cases, all of them with advanced stages of atherosclerosis, were positive. Subsequent sequence analysis revealed high identities (94%–100%) with Chlamydophila psittaci in three cases. Interestingly, two of these birds came from C. psittaci–infected populations. Because of the low incidence (3.9%), the occurrence only in advanced stages, and the association with C. psittaci–infected avian populations, a causal relationship between chlamydiae and atherosclerosis in pet birds is rather improbable.
Radiofrequency Ablation of Metastases from Osteosarcoma in Patients Under 25 Years: The SCFE Experience

Background: Radiofrequency ablation (RFA) has demonstrated its effectiveness in controlling metastases measuring less than 3 cm in several adult malignancies but not yet in osteosarcoma. We report our experience of RFA in the treatment of metastases in adolescents and young adults (AYA) with osteosarcoma. Procedure: Sixteen patients treated for osteosarcoma in French Society of Childhood Cancer centers had undergone an RFA procedure between 2006 and 2012. Results: Thirteen sessions were performed in 10 patients to treat 22 lung metastases. Seven patients were in complete remission at last follow up (range 19–51 months; median, 24 months after RFA). None had a recurrence at RFA sites. We report three cases each of hemoptysis and pneumothorax. Eight sessions were performed in seven patients to treat bone lesions. Procedure was intended as: curative for a small metastatic lesion (n = 3, all in remission more than 3 years after); local control of small bone lesions in multi-metastatic diseases (n = 3); analgesia (n = 1). Complications included one first-degree burn, one fracture, and one soft tissue infection. Conclusions: RFA is feasible in AYA with osteosarcoma. It efficiently achieved local control of small peripheral lung metastases. Its role in the curative care of small secondary bone lesions remains to be confirmed.
Abnormalities in Event‐Related Potentials, N100, P200, P300 and Slow Wave in Schizophrenia

Abstract: Event‐related potentials were recorded in 54 schizophrenics and 88 age‐matched controls during a two‐tone discrimination (odd ball) task. All the subjects were free from medication. In the schizophrenics, the mean amplitudes of the N100, P300 and Slow Wave latency ranges were decreased, and the amplitude of the P200 latency range was greater than that for the controls. These reductions and the increase were found both for the ERPs elicited by rare target stimuli and for those elicited by frequent nontarget stimuli. The peak latency of N200 to rare stimuli was more prolonged in the schizophrenics than in the controls. This finding confirms the prolongation of N200 latency that Brecher et al. (1987) found for a different visual stimuli task. Neither the N100 nor P300 latency differed between the two groups.
Breastfeeding in mothers with systemic lupus erythematosus

Introduction Breastfeeding is known to improve the well-being of a mother and her infant, and about half of all new mothers breastfeed, but it is unknown how breastfeeding is pursued in systemic lupus erythematosus (SLE; lupus) patients. We sought to determine the rate of breastfeeding and the factors influencing this among women with lupus. In addition, we reassessed the current safety data in lactation of lupus medications. Methods Data were collected from lupus patients enrolled in a prospective registry who fulfilled the 2012 SLICC criteria, had a live birth, and for whom postpartum breastfeeding status was known. Data included physician assessments of lupus activity and medications, breastfeeding intentions during pregnancy and practice following pregnancy. The safety of medications in breastfed infants was assessed through a comprehensive review of LactMed, a national database about medications in lactation. Results A total of 51 pregnancies in 84 women with lupus were included in the study. Half of the lupus patients (n = 25, 49%) chose to breastfeed. The rate of breastfeeding was not significantly affected by socioeconomic factors. In contrast, low postpartum lupus activity, term delivery, and a plan to breastfeed early in pregnancy were significantly associated with breastfeeding in lupus patients. In reviewing the most up-to-date data, the majority of lupus medications appear to have very minimal transfer into breast milk and are likely compatible with breastfeeding. Conclusion Half of women with lupus breastfed and most desire to breastfeed. Hydroxychloroquine, azathioprine, methotrexate, and prednisone have very limited transfer into breast milk and may be continued while breastfeeding.
Malcolm Baldrige National Quality Award leadership model

In this study, a Malcolm Baldrige National Quality Award (MBNQA) criteria‐based survey was used to assess the quality status of organizations that employ quality professionals. The objective was to focus on the relationship between leadership (LS), information and analysis, human resource planning, process quality, and customer focus. The result was the development of an MBNQA‐based model that demonstrated the relationship between executive LS and the MBNQA factors.
Characterization of Blue-light and Developmental Regulation of the Photolyase gene phr1 in Trichoderma harzianum

Abstract Blue light and development regulate the expression of the phr1 gene of the filamentous fungus Trichoderma harzianum. The predicted product of phr1, the DNA repair enzyme photolyase, is likely to help protect Trichoderma, which grows in the soil as a mycoparasite or saprophyte, from damage upon emergence and exposure to ultraviolet-c. phr1 is transiently expressed in mycelium and conidiophores after illumination. phr1 mRNA also accumulates in conidiophores during development and spore maturation. As no other genes displaying rapid, direct light regulation have been described previously in this organism, we have characterized the fluence and time dependence of phr1 induction, and its relation to sporulation and photoreactivation. Induction is transient following a pulse, and, with slower decay, in continuous light. This implies that the photoreceptor, transducers or response are capable of adaptation. About two-fold more light is required to induce phr1 than conidiation, but this difference is modest, so both responses could use the same or similar chromophore. Adenosine 3′:5′-cyclic monophosphate bypasses the requirement for light for sporulation, while atropine prevents sporulation even after photoinduction. Light regulation of phr1, however, is indifferent to both these effectors. Induction of photolyase expression behaves as a direct, rapid response to light, independent of the induction of sporulation. Indeed, illumination of mature spores increases their capacity for photoreactivation. Blue light seems to warn the organism against the harmful effects of short wavelengths, inducing phr1 expression and sporulation by pathways that are, at least in part, distinct.
Molecular Evolution Perspectives on Intraspecific Lateral DNA Transfer of Topoisomerase and Gyrase Loci in Streptococcus pneumoniae, with Implications for Fluoroquinolone Resistance Development and Spread

ABSTRACT Fluoroquinolones are an important class of antibiotics for the treatment of infections arising from the gram-positive respiratory pathogen Streptococcus pneumoniae. Although there is evidence supporting interspecific lateral DNA transfer of fluoroquinolone target loci, no studies have specifically been designed to assess the role of intraspecific lateral transfer of these genes in the spread of fluoroquinolone resistance. This study involves a comparative evolutionary perspective, in which the evolutionary history of a diverse set of S. pneumoniae clinical isolates is reconstructed from an expanded multilocus sequence typing data set, with putative recombinants excluded. This control history is then assessed against networks of each of the four fluoroquinolone target loci from the same isolates. The results indicate that although the majority of fluoroquinolone target loci from this set of 60 isolates are consistent with a clonal dissemination hypothesis, 3 to 10% of the sequences are consistent with an intraspecific lateral transfer hypothesis. Also evident were examples of interspecific transfer, with two isolates possessing a parE-parC gene region arising from viridans group streptococci. The Spain 23F-1 clone is the most dominant fluoroquinolone-nonsusceptible clone in this set of isolates, and the analysis suggests that its members act as frequent donors of fluoroquinolone-nonsusceptible loci. Although the majority of fluoroquinolone target gene sequences in this set of isolates can be explained on the basis of clonal dissemination, a significant number are more parsimoniously explained by intraspecific lateral DNA transfer, and in situations of high S. pneumoniae population density, such events could be an important means of resistance spread.
Homocysteine and the vascular endothelium.

Obstruction to the circulation has catastrophic consequences. On the high-flow arterial side acknowledged risk factors include dyslipidaemia, smoking, poorly controlled hypertension and renal disease. Additionally, venous thrombosis correlates with obesity, hormonal imbalance and reduced mobility especially when this is combined with dehydration, for example in long-distance air travel. Superimposed upon such environmental predictors of hypercoagulability is an impressively expanding list of genetic determinants that impair functional integrity of intimal cells, and this happens irrespective of anatomical site. Among these are reduced levels of antithrombin III, protein C or S and mutations in factor II or V, with the latter giving rise to resistance in protective effects of activated protein C. Furthermore there is an increasing awareness of the adverse effects that follow sustained elevation in plasma homocysteine levels. This may be hereditary and so explain the familial occurrence of premature vascular disease whether in the cerebral, coronary or peripheral circulations, but an abundance of data document the comparable hazard that is acquired with renal or hepatic failure or with use of many drugs. 1
BCL2 mutations do not confer adverse prognosis in follicular lymphoma patients treated with rituximab

BCL2 mutations have been suggested to confer an adverse prognosis to follicular lymphoma (FL) patients, but their prognostic value has not been assessed in patients treated with a rituximab‐containing regimen. Here we evaluated the prognostic value of BCL2 mutations in a large prospective cohort of 252 patients with FL treated with immunochemotherapy in the PRIMA randomized trial. Using a DNA‐targeted sequencing approach, we detected amino acid altering mutations in 135 patients (54%) and showed that these mutations were probably mediated by the over‐activation of AICDA (activation‐induced cytidine deaminase) in the context of the t(14;18) translocation. The BCL2 variants identified in PRIMA patients affected the BH1, BH2, and BH3 functional motifs at a lower frequency than the N‐terminus and flexible loop domain, with mostly conservative aminoacid changes. With a median follow‐up of 6.7 years, we did not observe any impact of BCL2 mutations either on overall survival or progression‐free survival.
CYCLIC ADENOSINE 3′,5′‐MONOPHOSPHATE CONTENT AND BRONCHIAL SMOOTH MUSCLE CONTRACTILITY OF HYPER‐ AND HYPOTHYROID LUNGS

1. Male Sprague‐Dawley rats were made either hyper‐ or hypothyroid with thyroxine or 4‐methyl‐2‐thiouracil, respectively. Bronchial smooth muscle (BSM) contractility and lung cyclic adenosine 3′,5′‐monophosphate (cAMP) content were measured in both conditions.
A novel back gated GaN/AlGaN HEMT structure for biological sensing applications

In this paper, a novel back gated AlGaN/GaN High Electron Mobility Transistor (HEMT) structure is proposed for detection of biological molecules such as nucleic acids (DNAs, RNAs). The proposed device consists of a thin film layer of AlGaN on top of a GaN thin film layer grown on a substrate such as sapphire or silicon, wherein the substrate is completely back etched exposing the GaN surface for attachment of nucleic acid molecules. Numerical study of this proposed device was carried out using TCAD Silvaco ATLAS to study the effect of attachment of nucleic acid molecules on the GaN surface. As the single-stranded and double-stranded DNA and RNA molecules are negatively charged, their attachment on the GaN surface leads to a variation of 2DEG gas on the AlGaN/GaN interface and therefore on the drain current. The performance of this structure is compared with an equivalent silicon MOS transistor and also with a conventional front gated HEMT structure. The proposed device shows a better sensitivity to presence of nucleic acid molecules in both the cases.
Friends Like Me: Associations in Overweight/Obese Status among Adolescent Friends by Race/Ethnicity, Sex, and Friendship Type.

BACKGROUND Little is known about how interpersonal friend relationships are associated with obesity in young people, particularly with regard to how race/ethnicity, type of friendship, and sex affect the association between friends' and adolescents' weight status. This study examined associations in weight status among adolescents and their friends, exploring magnitudes of associations across friendship type, sex, and race/ethnicity. METHODS As part of EAT-2010 (Eating and Activity in Teens), friend nominations and anthropometrics were obtained from adolescents (n = 2099: 54% female; 80% nonwhite; mean age: 14.2 ± 1.9 years). Generalized estimating equation logistic regression models were used to test associations between adolescents' overweight/obese status and friends' (i.e., friend group, female friends, male friends, female best friends, and male best friends) overweight/obese status. Interactions by adolescent race/ethnicity were examined. RESULTS The majority of significant associations were observed among white female adolescents' who had a 22-40% higher prevalence of overweight/obesity if their friends were overweight compared to white females whose friends were not overweight. In contrast, there were few significant differences for other adolescent female and male racial/ethnic groups for girls and boys. Results for friend groups and best friends were generally similar to one another. CONCLUSIONS The association between friend and adolescent overweight/obese status depended on adolescents' sex, race/ethnicity, and friendship type. Given the similarities among friends, obesity interventions targeting youth, especially white females, should consider involving friends.
The Effects of Hypnosis on Anxiety, Depression, Fatigue, and Sleepiness in People Undergoing Hemodialysis: A Clinical Report

Abstract This study investigated the effect of hypnosis on anxiety, depression, fatigue, and sleepiness in hemodialysis patients. Twenty-nine patients participated in the 15-day study. A single hypnosis session was performed on Day 8. Anxiety, depression, fatigue, and sleepiness were measured at baseline, on Day 8, and on Day 15 (HADS, MFI, ESS). Daily fatigue was also measured numerically. Anxiety, depression, and sleepiness significantly decreased after hypnosis. Weekly measures of fatigue remained stable; however, daily fatigue decreased.
PARAFUNCTIONAL HABITS, NIGHTGUARDS, AND ROOT FORM IMPLANTS

Occlusal schemes and designs of fixed and removable implant prostheses must satisfy requirements for the innocuous vertical loading of root form implants. Parafunctional habits (clenching, bruxing, or engaging) can transmit forces to the supporting bone that may result in destructive lateral stresses and overloading. Most nocturnal parafunctional habits can be ameliorated by acrylic resin nightguards. (Implant Dent 1994;3:261–263)
Personal Image Generasi Millennial Korban Cyberbullying Pada Akun Instagram dan Ask Fm Di Jakarta

Media sosial seperti Instagram dan Ask Fm dapat diakses oleh siapa saja, termasuk kaum millennial. Apalagi keadaan dan situasi pergaulan generasi millennial sekarang mendukung mereka untuk terpaksa mengikuti perkembangan zaman. Hal ini mendekatkan mereka ke dalam kasus cyberbullying. Terkait dengan ini, peneliti tergerak untuk mengetahui personal branding para korban cyberbullying di media sosial mereka masing-masing dalam memperbaiki serta mempertahankan citra diri. Selain itu, hambatan dan solusi generasi millennial korban cyberbullying juga akan menjadi topik utama dalam pembahasan ini. Penelitian dijalankan dengan menggunakan metode deskriptif kualitatif studi kasus, melalui wawancara mendalam. Dari analisis menggunakan Miles & Huberman, ditemukan bahwa personal branding dalam mempertahankan citra diri yang terbentuk dalam sosial media, baik itu Instagram dan Ask Fm para korban tidak selalu dapat diterima oleh masyarakat sekitar. Karena masyarakat selalu memiliki persepsi dan ekspektasi yang berbeda-beda terhadap pribadi masing-masing korban cyberbullying. Hambatan para korban cyberbullying disini adalah mendapatkan kepercayaan kembali dari masyarakat (social pressure) dalam memperbaiki citra diri mereka. Solusi yang ditemukan adalah dengan cara memperbanyak kegiatan positif dan memfilter unggahan ke dalam sosial media mereka.
Combinations of the presence or absence of cerebral microbleeds and advanced white matter hyperintensity as predictors of subsequent stroke types.

BACKGROUND AND PURPOSE Previous studies have shown microbleeds to be a risk factor for intracerebral hemorrhage and white matter hyperintensity (WMH) to be a risk factor for ischemic stroke. This study was performed to determine whether combinations of the presence or absence of microbleeds and advanced WMH are risk factors for subsequent recurrent stroke types. METHODS In 266 patients with stroke, microbleeds on T2*-weighted MR images were counted, and WMH on T2-weighted images was graded. Patients were divided into 4 groups by the combinations of the presence or absence of microbleeds and advanced WMH and were followed up for stroke recurrence. RESULTS During a mean follow-up period of 564.8 +/- 220.5 days, 26 patients developed recurrent strokes, including 10 intracerebral hemorrhages and 16 ischemic strokes. Patients with microbleeds without advanced WMH (n = 42) developed only intracerebral hemorrhages (n = 8), and the recurrence rate of intracerebral hemorrhage in those patients estimated by the Kaplan-Meier method was the highest in the 4 groups (14.3% in 1 year and 21.2% in 2 years). In contrast, patients with advanced WMH without microbleeds (n = 39) developed only ischemic strokes (n = 6), and the estimated recurrent rate of ischemic stroke in those patients was the highest in the 4 groups (10.5% in 1 year and 17.4% in 2 years). Cox proportional hazards regression analysis revealed that microbleeds were associated with intracerebral hemorrhage (hazard ratio [HR], 85.626; 95% confidence interval [CI], 6.344-1155.649) and that advanced WMH was negatively associated with intracerebral hemorrhage (HR, 0.016; 95% CI, 0.001-0.258). Advanced WMH was associated with ischemic stroke (HR, 10.659; 95% CI, 2.601-43.678). CONCLUSION It appears that patients at high risk of subsequent intracerebral hemorrhage or ischemic stroke can be identified by combinations of the presence or absence of microbleeds and advanced WMH.
VlabEmbed - the New Plugin Moodle for the Chemistry Education

Research goals: The necessity of developing a plugin for Moodle, which is used to support the activities of experimental chemistry are substantiated. Description of created VlabEmbed plugin and the process of installing and configuring VlabEmbed plugin in system Moodle are reviewed. Object of research: Moodle plugins for chemistry education. Subject of research: VlabEmbed – the new plugin Moodle for the chemistry education. Research methods: review and analysis of scientific publications and Moodle plugins for the chemistry education. Results of the research: VlabEmbed plugin in system Moodle are created.