Miracle-dz/UniFAR-FTUs huggingface dataset:
Masked smoking‐related images modulate brain activity in smokers

The questions of whether and how indiscriminate drug‐related stimuli could influence drug‐users are important to our understanding of addictive behavior, but the answers are still inconclusive. In the present preliminary functional magnetic resonance imaging study using a backward masking paradigm, the effect of indiscriminate smoking‐related stimuli on 10 smokers and 10 nonsmokers was examined. The BOLD response showed a significant reduction (P = 0.001) in the right amygdala of smokers when they viewed but did not perceive masked smoking‐related stimuli, while no significant differences were found in the nonsmoker group. More voxels in anterior cingulate cortex were negatively correlated with the amygdala during the masked smoking‐related picture condition in smokers but not in nonsmokers, whereas more positively correlated voxels were observed during the masked neutral condition. The BOLD response in drug‐users indicates the amygdala responds to drug‐related stimuli that are below the perceptual threshold. The functional connectivity data suggest a functional interaction between the amygdala and the anterior cingulate cortex when drug users view 33ms back‐masked drug‐related stimuli. This observation suggests that the amygdala plays an important role in the indiscriminate drug‐related cue process. Hum Brain Mapp, 2009. © 2008 Wiley‐Liss, Inc.
Unsettled weather and the end for thiopental? Obstetric general anaesthesia after the NAP5 and MBRRACE‐UK reports

Late 2014 saw the publication of two major reports that behove anaesthetists to reflect on the current practice of general anaesthesia in obstetrics. The 5th National Audit Project (NAP5) investigated accidental awareness under general anaesthesia and produced some important, if not surprising, results [1–3]. In keeping with the previous two National Audit Projects, the unique challenges of obstetric anaesthesia were underlined. Just a few months later, the Report on Confidential Enquiries into Maternal Deaths – now organised and delivered by a new consortium, MBRRACE-UK (Mothers and Babies: Reducing Risk through Audit and Confidential Enquiries across the UK) – reported its findings for 2009-12 [4, 5]. At first sight, one might think that the two reports have little to do with each other, with one about patients who wake up during anaesthesia and one about patients who don’t wake up at all. But both of these scenarios are common fears of patients undergoing anaesthesia, and whilst the two studies start in very different places, they converge in a number of areas.
Important wheelchair skills for new manual wheelchair users: health care professional and wheelchair user perspectives

Abstract Purpose: The purpose of this project was to identify wheelchair skills currently being taught to new manual wheelchair users, identify areas of importance for manual wheelchair skills' training during initial rehabilitation, identify similarities and differences between the perspectives of health care professionals and manual wheelchair users and use the ICF to organize themes related to rehabilitation and learning how to use a manual wheelchair. Method: Focus groups were conducted with health care professionals and experienced manual wheelchair users. ICF codes were used to identify focus group themes. Results: The Activities and Participation codes were more frequently used than Structure, Function and Environment codes. Wheelchair skills identified as important for new manual wheelchair users included propulsion techniques, transfers in an out of the wheelchair, providing maintenance to the wheelchair and navigating barriers such as curbs, ramps and rough terrain. Health care professionals and manual wheelchair users identified the need to incorporate the environment (home and community) into the wheelchair training program. Conclusions: Identifying essential components for training the proper propulsion mechanics and wheelchair skills in new manual wheelchair users is an important step in preventing future health and participation restrictions. Implications for Rehabilitation Wheelchair skills are being addressed frequently during rehabilitation at the activity-dependent level. Propulsion techniques, transfers in an out of the wheelchair, providing maintenance to the wheelchair and navigating barriers such as curbs, ramps and rough terrain are important skills to address during wheelchair training. Environment factors (in the home and community) are important to incorporate into wheelchair training to maximize safe and multiple-environmental-setting uses of manual wheelchairs. The ICF has application to understanding manual wheelchair rehabilitation for wheelchair users and therapists for improving the understanding of manual wheelchair use.
Long memory in US real output per capita

This article analyses the long memory properties of quarterly real output per capita in the US (1948Q1–2008Q3) using non-parametric, semi-parametric and parametric techniques. The results vary substantially depending on the methodology employed. Evidence of mean reversion is obtained in a parametric context if the underlying disturbances are weakly autocorrelated. We also examine the possibility of a structural break in the data and the results indicate that there is a slight reduction in the degree of persistence after the break that is found to occur in the second quarter of 1978.
Ectopic Prostatic Tissue in the Uterine Cervix: A Report of Four Cases and Review of Ectopic Prostatic Tissue

We report four examples of prostatic tissue occurring in the uterine cervix of patients aged 22, 25, 31, and 77 years. Three were incidental findings in loop excisions (two patients) and cone biopsy (one patient) of the cervix for high-grade squamous dysplasia. One presented as a cervical mass, clinically suspected to represent a fibroid. The prostatic tissue consisted of ducts and acini, some of which had papillary or cribriform patterns. Squamous metaplasia was prominent in all cases. No Wolffian duct tissue was present. The glandular epithelium in all cases was positive for prostatic acid phosphatase and prostate-specific antigen. High molecular weight keratin, performed in two cases, highlighted basal cells in a manner similar to the normal prostate. These unusual cases, only one of which is documented previously, further complicate the often-challenging area of interpretation of benign glandular lesions of the cervix. The unusual phenomenon of ectopic prostate tissue in general is reviewed.
Safety of fluoroquinolones in paediatrics

In the last few years, there has been increasing pressure to use fluoroquinolones in paediatric patients, since these antibiotics offer the advantage of an oral treatment regimen on an out-patient basis. However, even although this class of antibiotics generally remains well-tolerated, the restriction of fluoroquinolone use in children on a compassionate basis, which derives from their potential to cause cartilage toxicity, limits the safety data in this population and suggests a cautious use. This review reports the data of the literature on the safety of fluoroquinolones in different districts, focusing on the side effects in children and drug interactions. Moreover, data available in the literature with regards to side effects in children are reported, with particular attention to their potential in arthropathy.
The Role of Haptic Exploration of Ground Surface Information in Perception of Overhead Reachability

The authors performed an experiment in which participants (N = 24) made judgments about maximum jump and reachability on ground surfaces with different elastic properties: sand and a trampoline. Participants performed judgments in two conditions: (a) while standing and after having recently jumped on the surface in question and (b) while standing on a third control surface, eliminating haptic exploration of the surface in question. There was a high correlation between perceived maximum reachable height and actual maximum reachable height in all conditions. Judging performance on the basis of visual and haptic exploration of ground surface information was slightly overestimated, whereas performance on the basis of visual information alone was underestimated and variable for the different surfaces. The authors discuss possible causes for the observed errors. They emphasize that there is a considerable nonvisual aspect to the nature of the information specifying affordances for overhead reach and jumping and that perceptual performance is degraded when spontaneous exploratory movement is restricted.
Antioxidant activity of the methanol fraction of Pluchea indica root extract

Studies were carried out to evaluate the influence of the methanol fraction of Pluchea indica Less root extract (PIRE), the dual inhibitors (BW 755C and phenidone) and vitamin on both in vivo and in vitro free radical‐scavenging activities, CCl4‐induced lipid peroxidation and the metabolism of arachidonic acid by lipoxygenase. PIRE produced significant antiinflammatory activity against glucose oxidase‐induced paw oedema (in vivo), inhibited hydroxyl radical and superoxide generation, lysis of erythrocytes induced by hydrogen peroxide, CCl4‐induced lipid peroxidation and also dioxygenase activity of lipoxygenase (both in the presence and absence of hydrogen peroxide). Significantly higher free radical‐scavenging activity was observed with BW 755C and phenidone compared with PIRE. However, both BW 755C and phenidone stimulated hydroxyl radical generation compared with the observed inhibitory effects of PIRE and vitamin E. Copyright © 2002 John Wiley & Sons, Ltd.
Multiobjective fuzzy genetics-based machine learning with a reject option

Classifier design for a classification problem with M classes can be viewed as finding an optimal partition of its pattern space into M disjoint subspaces. However, this is not always a good strategy especially when training patterns from different classes are heavily overlapping in the pattern space. A simple but practically useful idea is the use of a reject option. In this case, the pattern space is partitioned into (M+1) disjoint subspace where the classification of new patterns is rejected in the (M+1)th subspace. In this paper, we discuss the design of fuzzy rule-based classifiers with a reject option. The rejection subspace is specified by a threshold value for the difference of a kind of matching degrees between the best matching class and the second best matching class. The important research question is how to specify the threshold value. We examine the following two approaches: One is manual specification after designing a fuzzy rule-based classifier, and the other is simultaneous multiobjective optimization of a threshold value and a fuzzy rule-based classifier. In the latter approach, we use three objectives: maximization of the correct classification, and minimization of the rejection and the complexity of the classifier.
The Biosynthesis of Melanin‐Concentrating Hormone in Trout Kept Under Different Conditions of Background Colour and Stress, as Determined by an in vitro Method

The aim of this study was to develop a method to monitor the synthetic activity of neurons which secrete the neurohypophysial melanin‐concentrating hormone (MCH), a hormone implicated in two separate physiological roles in fish—pigmentary regulation and the response to stress. Trout hypothalamic fragments, containing the MCH neuronal cell bodies, were incubated in vitro in a medium including [35S]methionine. Labelled MCH‐related products were separated by immunoprecipitation. Gel electrophoresis showed that radioactive methionine was incorporated into MCH precursors and into mature MCH, much as in vivo. Thus, de novo hormone synthesis continues in vitro. Trout reared at a fish‐farm and adapted to black or white tanks for 39 days displayed nearly a 2‐fold difference in their rate of methionine incorporation. Transferring fish from a black to a white background also doubled the rate of incorporation within 7 days and this rate increased only very slightly during the following 3 weeks. The rate of methionine incorporation by tissue from trout reared in black tanks was very depressed, and 4‐fold lower than that of fish reared in white tanks, suggesting that very long‐term adaptation to one or other background has increasingly marked effects on the activity and perhaps the number of synthetically active neurons.
Men’s perceptions and attitudes toward their wives experiencing menopause

ABSTRACT In this study, we explore men’s perceptions, experiences, and attitudes toward wives experiencing natural menopause. We interviewed 20 men using the oral history method. Descriptive categories of experiences, such as misconceptions about menopause overcome through coexistence and recognition of women’s perspectives; recognition of women’s needs and efforts to provide support; coping with changes in marital relations and need to start a new time in couple’s life; and existence of several needs as husbands of women experiencing menopause were explored. A better understanding by men about the changes experienced by menopausal women fosters the development of a better emotional support for their wives, which improves the quality of marital relations.
Degradation of STAT1 and STAT2 by the V Proteins of Simian Virus 5 and Human Parainfluenza Virus Type 2, Respectively: Consequences for Virus Replication in the Presence of Alpha/Beta and Gamma Interferons

ABSTRACT Human cell lines were isolated that express the V protein of either simian virus 5 (SV5) or human parainfluenza virus type 2 (hPIV2); the cell lines were termed 2f/SV5-V and 2f/PIV2-V, respectively. STAT1 was not detectable in 2f/SV5-V cells, and the cells failed to signal in response to either alpha/beta interferons (IFN-α and IFN-β, or IFN-α/β) or gamma interferon (IFN-γ). In contrast, STAT2 was absent from 2f/PIV2-V cells, and IFN-α/β but not IFN-γ signaling was blocked in these cells. Treatment of both 2f/SV5-V and 2f/PIV2-V cells with a proteasome inhibitor allowed the respective STAT levels to accumulate at rates similar to those seen in 2fTGH cells, indicating that the V proteins target the STATs for proteasomal degradation. Infection with SV5 can lead to a complete loss of both phosphorylated and nonphosphorylated forms of STAT1 by 6 h postinfection. Since the turnover of STAT1 in uninfected cells is longer than 24 h, we conclude that degradation of STAT1 is the main mechanism by which SV5 blocks interferon (IFN) signaling. Pretreatment of 2fTGH cells with IFN-α severely inhibited both SV5 and hPIV2 protein synthesis. However, and in marked contrast, pretreatment of 2fTGH cells with IFN-γ had little obvious effect on SV5 protein synthesis but did significantly reduce the replication of hPIV2. Pretreament with IFN-α or IFN-γ did not induce an antiviral state in 2f/SV5-V cells, indicating either that the induction of an antiviral state is completely dependent on STAT signaling or that the V protein interferes with other, STAT-independent cell signaling pathways that may be induced by IFNs. Even though SV5 blocked IFN signaling, the addition of exogenous IFN-α to the culture medium of 2fTGH cells 12 h after a low-multiplicity infection with SV5 significantly reduced the subsequent cell-to-cell spread of virus. The significance of the results in terms of the strategy that these viruses have evolved to circumvent the IFN response is discussed.
Gonadal function in young patients successfully treated for Hodgkin disease.

BACKGROUND Gonadal function in pediatric and young adult survivors of Hodgkin disease is not very well defined. This study evaluates the outcome following the Multiple Drug Protocol (MDP) and the results are compared to the published experience. PROCEDURE Ovarian and testicular function was assessed in 65 patients (36 males) with Hodgkin disease in first or second complete remission after treatment with either radiation (RT, n = 13), chemotherapy (CT, n = 9), or both (n = 43). Chemotherapy consisted of six cycles of the MDP (doxorubicin, procarbazine, prednisone, vincristine, and cyclophosphamide). Median age at diagnosis was 13.1 years (range, 2.4-22.6) and median age at evaluation was 22.6 years (range, 15.1-33.7), which was 6.7 years (range, 2.0-19.8) after the completion of all treatments. For the purpose of analysis, patients were divided into three groups: group A, patients who received only RT that did not include the pelvis (8 females, 5 males); group B, patients who received CT but no pelvic RT (15 females, 25 males); and group C, patients who received CT plus pelvic RT (6 females, 6 males). RESULTS All patients progressed spontaneously through puberty and evaluable patients were found to be sexually mature (Tanner stage IV and V). Serum follicle stimulating hormone (FSH) was increased in 0/5, 13/25, and 5/6 and testicular volume was decreased in 1/3, 4/11, and 2/3 group A, B, and C male patients, respectively. Leydig cell dysfunction was uncommon; 91% and 88% of males had normal serum concentrations of luteinizing hormone (LH) and testosterone, respectively. FSH and LH were increased in 0/8, 3/15, and 2/6 group A, B, and C female patients, respectively, at last follow-up, indicating a 17% prevalence of ovarian dysfunction. Serial data in seven females whose initial levels of FSH/LH were elevated revealed normalization in four. Six females delivered eight normal children. CONCLUSIONS The majority of males who received CT +/- RT have evidence of germ cell dysfunction, while Leydig cell function is unaffected in most. In females, although abnormal function early after the end of treatment was observed, ovarian function remained or returned to normal in most young women. Thus, in females the results of hormone testing performed early after treatment may not be predictive of their eventual reproductive potential.
Immunoglobulin concentrations in serum and nasal secretions of calves at the onset of pneumonia.

Immunoglobulin (Ig) concentrations in serum and in nasal secretions were correlated with pneumonia and diarrhea during the first 12 weeks of life in 56 calves. The peak onset of pneumonia occurred between 2 and 4 weeks of age when the calves' serum IgG1, IgG2, and IgA concentrations were lowest. As IgG2 concentrations increased, fewer calves developed pneumonia. Peak onset of pneumonia was also correlated with the lowest IgG and IgA concentrations in the calves' nasal secretions. Most calves developed pneumonia when serum concentrations of IgG1 were less than 1.5 g/dl, IgG2 less than 0.3 g/dl, IgA less than 0.1 g/dl, and IgM less than 0.2 g/dl and when the combined IgG and IgA values in nasal secretions were less than 0.2 mg of Ig/mg of protein. In study A, diarrhea preceded pneumonia in 63% of 56 calves. In study B, 38% of 23 calves had diarrhea and/or hemorrhagic feces before pneumonia. Seemingly, there was a relationship between diarrhea and pneumonia. Furthermore, pneumonia occurred at or just after the time when IgG1, IgG2, and IgA concentrations in serum and the combined IgG and IgA concentrations in nasal secretions were lowest. Pneumonia is a common disease of calves between 1 and 5 months of age, a period coinciding with the usual low point in serum immunoglobulin (Ig) concentrations due to catabolism of passively acquired antibodies. Calves that absorb less than adequate amounts of Ig may be susceptible to pneumonia at approximately 2 months of age, when serum Ig concentrations would be lowest. (ABSTRACT TRUNCATED AT 250 WORDS)
Myxoid variant of malignant fibrous histiocytoma

It has not been generally recognized that malignant fibrous histiocytoma (MFH) may assume a highly myxoid, hypocellular appearance. Eighty cases of malignant fibrous histiocytoma having varying degrees of myxoid change were reviewed. These tumors typically arose on the extremities (leg, 61%; arm, 21%) of adults (peak age incidence, 60–69 years). They were usually attached to fascia (31%) or involved skeletal muscle (51%) and had a mucoid or translucent appearance. The myxoid areas consisted of widely spaced spindled and pleomorphic cells embedded in a matrix of acid mucopolysaccharides. The cellular areas were indistinguishable from those of the typical pleomorphic MFH. The rate of local recurrence of these tumors was 61%, and of metastasis, 23%, but metastasis was less likely when the tumor was small, superficially located, or had a prominent myxoid component. In fact, the degree of myxoid change was inversely related to the rate of metastasis. Therefore, because of the more favorable prognosis of the myxoid variant, it seems appropriate to separate it from the usual nonmyxoid form of MFH. The myxoid variant must also be clearly distinguished from benign myxoid lesions such as myxoma or nodular fasciitis, with which it is often confused.
The History of Atrial Fibrillation: The Last 100 Years

Atrial fibrillation (AF) has had a rich history that has touched the careers of many of the great clinicians and investigators of the 20th century. More recently, there has been an explosion of research into various aspects of the mechanisms and therapy for AF, as evidenced by over 8,000 publications on AF from 2000 to 2007. A century of research and clinical observations, coupled with modern investigative technologies, has enabled modern investigators to have their own “fantastic voyage” as they travel beyond the cell borders into the ionic mechanisms responsible for AF and its many atrial perturbations. One can only imagine the satisfaction of Wenckebach, MacKenzie, and Lewis if they could see how their seeds of wisdom have grown into such sturdy ideas, or how delighted Scherf would be to learn that his ectopic focus theory for AF has been given new life.
Optical Path Cross-Connect System Scale Evaluation Using Path Accommodation Design for Restricted Wavelength Multiplexing

The optical path (OP) technology, which employs both wavelength-division multiplexing and wavelength routing, will be the key to enhanced network integrity and an ubiquitous broadband integrated services digital network (B-ISDN) in the future. To construct the OP network, path accommodation design that can solve simultaneously the problems of path routing and wavelength assignment must be established. Since optical wavelengths are scarce resources, even with state-of-the-art technologies, the available number of wavelengths that can be multiplexed into a fiber is restricted to a relatively small number. This entails space division multiplexing with multiple fibers in the link in order to accommodate the large number of paths within a link. This paper proposes novel OP accommodation design algorithms that can heuristically establish wavelength paths (WPs) or virtual wavelength paths (VWPs) in the network, where each link is composed of multiple fibers. These algorithms minimize the average number of fibers (in other words, cross-connect ports) handled at the WP/VWP cross-connect nodes and enable us to obtain the required OP cross-connect (OPXC) system scale at each node in WP/VWP networks. Algorithms that consider failure restoration are also proposed. Some WP/VWP accommodation designs over a polygrid network are simulated using the proposed algorithms. The difference between the WP and VWP schemes in terms of the required OPXC system scale with and without considering failure restoration is quantitatively evaluated for the first time.
SENSITIVITY AND SPECIFICITY OF BI-RADS SCORING SYSTEM IN CARCINOMA OF BREAST

Mammography, Breast carcinoma, BI-RADS Female patients who presented with clinically palpable breast lumps or nipple discharge in general surgical OPD were examined and referred for mammography. Ultrasound examination was also done where considered necessary. The final diagnosis regarding the lump or nipple discharge as shown in the mammography was made and patients sent for biopsy (FNAC / Trucut / excision biopsy). The mammographic diagnosis was compared with the histopathological report. FARHAT ARSALAN, ANIS SUBHAN, SHAHID RASUL, UZMA JALALI, MAHAM YOUSUF, ZAHID MEHMOOD, ASADULLAH KHAN.