Miracle-dz/UniFAR-FTUs huggingface dataset:
PREVENTION OF BONE LOSS AND FRACTURE AFTER LUNG TRANSPLANTATION: A PILOT STUDY

Background. Osteoporotic fracture is a significant source of morbidity after lung transplantation. Therapies to prevent posttransplant fracture are largely untested among lung transplant recipients. Methods. In this prospective uncontrolled study, lung transplant referrals were assessed for bone health with metabolic, radiographic, and bone mineral density measurements. Transplant recipients were treated with an antiresorptive regimen that included a bisphosphonate starting before or after transplantation. One year after transplantation, the fracture rate and bone density of patients in each group were reassessed and compared to historical controls. Between January 1996 and August 1999, 45/50 (90%) lung transplant referrals underwent bone health assessment. Transplant candidates received calcium, vitamin D, and hormone replacement therapy as indicated for hypogonadism. After July 1998, bisphosphonate therapy was added for candidates with osteopenia or osteoporosis (T score <1). After transplantation, all patients received 90 mg of pamidronate i.v. every 12 weeks, regardless of pretransplant bone density. Radiologic evaluation was performed for clinical suspicion of fracture. Bone density was remeasured 1 year after transplantation. Results. Most transplant referrals suffered from osteopenia or osteoporosis, and 29% of transplant referrals had prevalent vertebral compression fractures. Hypogonadism was untreated in 50% of men and 20% of women, and 15% of patients had hypovitaminosis D. Of the 21 patients assessed 1 year after transplantation, new fractures occurred in 4% of these patients. Lateral lumbar spine and hip bone density remained stable or improved in 65% and 86% of patients, respectively. Most of those who lost bone density had started bisphosphonate therapy after transplantation. Conclusions. Antiresorptive therapy with a bisphosphonate decreases the fracture rate and preserves bone mass 1 year after lung transplantation. In end-stage lung disease patients with osteopenia or osteoporosis, bisphosphonate therapy should be initiated before transplant surgery is contemplated.
Sudden Deaths: Taking Stock of Geographic Ties

Abstract Analysis of a worldwide sample of sudden deaths of politicians reveals a market-adjusted 1.7% decline in the value of companies headquartered in the politician's hometown. The decline in value is followed by a drop in the rate of growth in sales and access to credit. Our results are particularly pronounced for family firms, firms with high growth prospects, firms in industries over which the politician has jurisdiction, and firms headquartered in highly corrupt countries.
Mixotrophic Activity and Diversity of Antarctic Marine Protists in Austral Summer

Identifying putative mixotrophic protist species in the environment is important for understanding their behavior, with the recovery of these species in culture essential for determining the triggers of feeding, grazing rates and overall impact on bacterial standing stocks. In this project, mixotroph abundances determined using tracer ingestion in water and sea ice samples collected in the Ross Sea, Antarctica during the summer of 2011 were compared with data from the spring (Ross Sea) and fall (Arctic) to examine the impacts of bacterivory/mixotrophy. Mixotrophic nanoplankton were usually less abundant than heterotrophs, but consumed more of the bacterial standing stock per day due to relatively higher ingestion rates (1-7 bacteria mixotroph-1 h-1 vs. 0.1-4 bacteria heterotroph-1 h-1). Yet, even with these high rates observed in the Antarctic summer, mixotrophs appeared to have a smaller contribution to bacterivory than in the Antarctic spring. Additionaly, putative mixotroph taxa were identified through incubation experiments accomplished with bromodeoxyuridine labeled bacteria as food, immunoprecipitation (IP) of labeled DNA, and amplification and high throughput sequencing of the eukaryotic ribosomal V9 region. Putative mixotroph OTUs were identified in the IP samples by taxonomic similarity to known phototroph taxa. OTUs that had increased abundance in IP samples compared to the non-IP samples from both surface and chlorophyll maximum (CM) depths were considered to represent active mixotrophy and include ones taxonomically similar to Dictyocha, Gymnodinium, Pentapharsodinium and Symbiodinium. These OTUs represent target taxa for isolation and laboratory experiments on triggers for mixotrophy, to be combined with qPCR to estimate their abundance, seasonal distribution and potential impact.
A Monte Carlo pharmacokinetic/pharmacodynamic simulation to evaluate the efficacy of minocycline, tigecycline, moxifloxacin, and levofloxacin in the treatment of hospital-acquired pneumonia caused by Stenotrophomonas maltophilia

Abstract Background: Stenotrophomonas maltophilia has emerged as an important opportunistic pathogen in recent years. Increasing antimicrobial resistance and other contraindications have greatly compromised trimethoprim/sulfamethoxazole (SXT) as the first-line therapeutic option. The objective of this study was to explore other options for treating hospital-acquired pneumonia (HAP) caused by S. maltophilia. Methods: A total of 102 strains of S. maltophilia were isolated from sputum and bronchoalveolar lavage (BAL) specimens of patients with HAP in our institution. The minimum inhibitory concentration (MIC) values of minocycline, tigecycline, moxifloxacin, and levofloxacin were determined by the agar dilution method. Based on the MICs and the population pharmacokinetic parameters of the investigated antimicrobials, a Monte Carlo simulation was performed to simulate the pharmacokinetic/pharmacodynamic (PK/PD) indices of different regimens. The probability of target attainment (PTA) was estimated at each MIC value and the cumulative fraction of response (CFR) was calculated to evaluate the efficacy of these regimens. Results: The susceptibility rates to minocycline, tigecycline, moxifloxacin, and levofloxacin were 96.1%, 80.4%, 74.5%, and 69.6%, respectively. The estimated CFRs were 96.2% for minocycline 100 mg twice daily; 50.8%/67.1%/75.4% for tigecycline 50/75/100 mg twice daily; 34.3%/48.0%/56.6% for levofloxacin 500/750/1000 mg once daily; and 45.7% for moxifloxacin 400 mg once daily. Conclusions: The simulation results suggest that minocycline may be a proper choice for treatment of HAP caused by S. maltophilia, while tigecycline, moxifloxacin, and levofloxacin may not be optimal as monotherapy.
Diacetonitrile[N,N′-bis(3,4,5-trimethoxybenzylidene)ethylenediamine]copper(I) perchlorate

In the title compound, [Cu(C2H3N)2(C22H28N2O6)]ClO4, the Cu atom is coordinated by two N atoms from one bidentate Schiff base ligand and two N atoms from two acetonitrile groups. The Cu atom adopts a tetrahedral geometry. The Cu—N(ligand) distances are 2.076 (3) and 2.089 (3) Å, and the Cu—N(acetonitrile) distances are 1.964 (4) and 1.975 (4) Å.
Metabolic rate, cardiac response, and aerobic capacity in fibromyalgia: a case–control study

Objectives: Several studies report reduced aerobic capacity in patients with fibromyalgia (FM). The purpose of our study was to investigate whether a reduction in aerobic capacity in these patients is accompanied by alterations in metabolic rate and heart rate (HR) response. Method: Twelve women with FM and 12 healthy controls (HCs) matched on sex and age, and with similar leisure time physical activity, participated in the study. All subjects performed an incremental submaximal cycle ergometer test to anaerobic threshold [AT; i.e. blood lactate concentration (bLa) ≥ 4 mmol/L], followed by a stepwise test to exhaustion to estimate maximal oxygen consumption (VO2max). Results: Oxygen consumption and workload were lower among patients than HCs both at AT and at termination of the VO2max test (p < 0.011 for all comparisons). Two patients (18%) and nine HCs (75%) reached VO2max criteria. The relationship between metabolic rate and workload did not differ between groups at exercise below AT. At exercise above AT, the metabolic rate increased disproportionally to workload in the patients. Although the patients had a higher anaerobic contribution to the total metabolic rate at the end of the submaximal test, the anaerobic contribution at the end of the maximal test did not differ between groups. HR responses were largely similar between groups. Conclusions: The current study indicates that patients with FM have similar metabolic and cardiovascular responses to submaximal exercise as HCs. However, these patients have reduced ability to reach VO2max and a possible deficit in the metabolic system when exercising above the AT.
Application of Protection Motivation Theory to Adoption of Protective Technologies

While most technology adoption models have focused on beneficial technologies, Protection Motivation Theory (PMT) is a potentially valuable model for predicting adoption of protective technologies, which help users avoid harm from a growing number of negative technologies, such as malware. We present a PMT-based model of users' intentions to adopt anti-spyware software and test the model on undergraduate student computer users. Results show that perceived vulnerability, perceived severity, response efficacy, and response cost influence behavioral intention to use anti-spyware software as a protective technology. Maladaptive coping was affected to a much lesser degree by these variables, although it did have its own significant effect on behavioral intention. Results are compared to the small but growing number of promising PMT-based research models investigating technology adoption.
Problems of undergraduate medical education in Saudi Arabia

Throughout the world there are problems associated with undergraduate medical education, and likewise in Saudi Arabia. In this paper, some of these problems are discussed and solutions suggested, in the context of a survey conducted at the Faculty of Medicine of King Abdulaziz University with fourth‐year medical students dealing with the language of medical instruction.
Multifunctional CD4+ T cells correlate with active Mycobacterium tuberculosis infection

Th1 CD4+ T cells and their derived cytokines are crucial for protection against Mycobacterium tuberculosis. Using multiparametric flow cytometry, we have evaluated the distribution of seven distinct functional states (IFN‐γ/IL‐2/TNF‐α triple expressors, IFN‐γ/IL‐2, IFN‐γ/TNF‐α or TNF‐α/IL‐2 double expressors or IFN‐γ, IL‐2 or TNF‐α single expressors) of CD4+ T cells in individuals with latent M. tuberculosis infection (LTBI) and active tuberculosis (TB). We found that triple expressors, while detectable in 85–90%TB patients, were only present in 10–15% of LTBI subjects. On the contrary, LTBI subjects had significantly higher (12‐ to 15‐fold) proportions of IL‐2/IFN‐γ double and IFN‐γ single expressors as compared with the other CD4+ T‐cell subsets. Proportions of the other double or single CD4+ T‐cell expressors did not differ between TB and LTBI subjects. These distinct IFN‐γ, IL‐2 and TNF‐α profiles of M. tuberculosis‐specific CD4+ T cells seem to be associated with live bacterial loads, as indicated by the decrease in frequency of multifunctional T cells in TB‐infected patients after completion of anti‐mycobacterial therapy. Our results suggest that phenotypic and functional signatures of CD4+ T cells may serve as immunological correlates of protection and curative host responses, and be a useful tool to monitor the efficacy of anti‐mycobacterial therapy.
Effect of hyperbarism on radiofrequency ablation outcome.

OBJECTIVE Our objective was to investigate whether increases in atmospheric or local tissue pressure would affect the outcome of radiofrequency ablation procedures and the size of the created thermal lesions. MATERIALS AND METHODS Thermal lesions were produced in specimens of explanted bovine liver inside a hyperbaric chamber at 101 (atmospheric), 141, 202, 273, and 364 kPa using radiofrequency power settings of 20, 30, 40, and 50 W. In subsequent in vivo experiments, thermal lesions were produced in the livers of anesthetized pigs with or without occlusion of the hepatic vein draining the ablation site. RESULTS At each radiofrequency power setting, progressive increases in applied pressure were paralleled by decreases in minimum impedance and increases in maximum tissue temperatures at the electrode tip (reflecting tissue-fluid boiling points), delivery time, total energy delivered, and thermal lesion volumes. Similar increases were observed in radiofrequency ablation procedures performed in vivo under occlusion of the vein draining the ablation site. CONCLUSION By elevating the tissue-fluid boiling point, increased pressure delays the desiccation of tissue in contact with the radiofrequency electrode tip and the related sharp increase in impedance. The result is prolonged delivery of larger amounts of radiofrequency energy and larger thermal lesions.
Distribution of corticotropin‐releasing factor (CRF) receptor binding in the mouse brain using a new, high‐affinity radioligand, [125I]‐PD‐Sauvagine

The corticotropin‐releasing factor (CRF) family of peptides includes CRF and three urocortins, which signal through two distinct G‐protein coupled receptors, CRF1 and CRF2. Although the cellular distribution of CRF receptor expression has been well characterized at the mRNA level, the localization of receptor protein, and, by inference, of functional receptors, has been limited by a lack of reliable immunohistochemical evidence. Recently, a CRF‐related peptide, termed PD‐sauvagine, was isolated from the skin of the frog, Pachymedusa dacnicolor, and validated as a high‐affinity ligand for CRF receptor studies. A radiolabeled analog, [125I]‐PD‐sauvagine, with high signal‐to‐noise ratio, was used in autoradiographic studies to map the distribution of CRF receptor binding sites in the mouse brain. Through the use of receptor‐deficient mice and subtype‐specific antagonists, CRF1 and CRF2 binding sites were isolated, and found to be readily reconcilable with regional patterns of mRNA expression. Binding site distributions within a given structure sometimes differed from mRNA patterns, however, particularly in laminated structures of the isocortex, hippocampus, and cerebellum, presumably reflecting the trafficking of receptors to their operational homes on neuronal (mostly dendritic) processes. Binding patterns of [125I]‐PD‐sauvagine provided independent assessments of controversial receptor localizations, failing to provide support for CRF1 expression in central autonomic components of the limbic forebrain, the locus coeruleus and cerebellar Purkinje cells, or for CRF2 in any aspect of the cerebellar cortex. Though lacking in ideal resolution, in vitro binding of the PD‐sauvagine radioligand currently provides the most sensitive and accurate available tool for localizing CRF receptors in rodent brain.
ICT solutions for the informal sector in developing economies: What can one expect?

In the dominant policy discourses, the informal sector is often treated as composed of millions of entrepreneurs who are stuck at small scales of business with low levels of productivity and incomes because of market imperfections, institutional rigidities, or regulatory bias. Technological inclusion is often considered a solution to the problem of institutional exclusion that the informal business owners face. Such policies are often based on the assumption that informal business owners behave like entrepreneurs. However, there is also an alternative view that informal business owners are forced to run businesses on their own account because they cannot find decent jobs in the formal or organized modern sector. Their skills and attitudes towards risk are very different from what we associate with entrepreneurs. Technology solutions in general—and information and communication technology (ICT) solutions in particular—are more likely to be effective in their developmental objectives, if a more nuanced and disaggregated view of the informal economy is adopted.
Protective effect of caffeine on streptozotocin‐induced beta‐cell damage in rats

Many epidemiological studies have shown that coffee consumption reduces the risk of type 2 diabetes mellitus (T2D), although the reasons as to why remain unclear. In this study we investigated the effect of caffeine on pancreatic beta‐cell damage in rats using the diabetogenic agent, streptozotocin (STZ). Wistar rats were given intraperitoneal injections of saline or caffeine (10, 50 or 100 mgkg−1). After 15 min, the rats were injected with a citrate buffer or 65 mgkg−1 STZ. Three days after injection, an oral glucose tolerance test (OGTT) was performed on the rats. Furthermore, three days after the OGTT, the pancreas was isolated and homogenized, followed by determination of insulin content. STZ treatment significantly increased the plasma glucose level compared with the control at all times during the OGTT, which was significantly diminished by caffeine pretreatment at all doses. STZ treatment significantly decreased the plasma insulin level, however, which was not recovered by caffeine pretreatment. Pancreatic insulin content was significantly reduced by STZ treatment compared with the control, which was significantly recovered by caffeine pretreatment at a dose of 100 mgkg−1 (P < 0.01). We showed that caffeine protects pancreatic beta‐cells against STZ toxicity. Further investigation will be required to understand the protective effect of caffeine against beta‐cell destruction in T2D.
The Impact of Auditor Quality, Financial Stability, and Financial Target for Fraudulent Financial Statement

This study analyzes the influence of financial stability, financial targets and the role of the quality of auditors against fraud measures financial statements. This study using purposive sampling and use of the 21 companies that commit fraud recorded in the financial statements of the Financial Services Authority and 21 companies did not commit fraud which includes compass 100 in the Indonesia Stock Exchange using logistic regression analysis. The study found a positive effect of variable quality auditor against fraudulent financial reports, found a negative influence financial stability and financial variables against the target of fraudulent financial statements. Limitation of this study are limited variables and proxy variables used to measure financial targets, further research is recommended to add the variables that affect the occurrence of acts of fraud financial statements, and look for a proxy for a target financial variables.
The Effects of Venlafaxine on Cortical Motor Area Activity in Healthy Subjects: A Pilot Study

Abstract In the study, we used functional magnetic resonance imaging associated with behavioral assessment to observe the effects of venlafaxine on the modulation of human motor cortex activation and to provide preliminary data for further assessing its influence on motor functional reorganization after stroke injury. In a randomized, double-blind, crossover study, 8 right-handed subjects received 75 mg of either venlafaxine or a placebo daily over a period of 7 days separated by 3 washout days. The volunteers were asked to execute motor tasks, which included the dynamometer and finger-tapping test. In addition, laboratory tests and functional magnetic resonance imaging examination, before the start of the experiment and after administration of placebo and venlafaxine, were performed. It was shown that the finger-tapping rate of each hand in the venlafaxine stage was significantly improved compared with that observed in the placebo stage (n = 8, Fleft hand = 57.69, Fright hand = 184.48, P < 0.001). The changes in the recorded grip strengths of both hands were not significant between the stages (n = 8, F = 2.63, P > 0.05). In the venlafaxine stage, the activations of the contralateral primary sensorimotor cortex, contralateral premotor cortex, and contralateral supplementary motor area were enhanced significantly, whereas the activation of the bilateral parietal cortices was decreased when compared with the placebo stage. Meanwhile, the enhancement of contralateral primary sensorimotor cortex activation had a positive correlation with the improvement of the finger-tapping rate. It was concluded that venlafaxine could modulate the cortical excitability and improve finger dexterity and reaction speed, which greatly related to the increase of contralateral motor cortical excitability.
Accuracy of peripheral nerve assessment in junior medical staff: is our knowledge of anatomy sufficient for practice?

Orthopaedic injuries are a frequent cause of emergency department visits, and essential to their evaluation is the peripheral nerve examination. Altered neurology can influence the urgency of orthopaedic assessment and management. Unrecognized neurology can have serious consequences, and lack of anatomical knowledge in junior doctors has an association with medico-legal liability and litigation. A recent shift in teaching methods towards problem-based learning (PBL) has resulted in substantial changes to anatomy education. Since this transition, there has been an 80% reduction in basic anatomy teaching across Australasian medical schools. Concern regarding this trend is growing, with 61% of UK consultants believing the standard of anatomy teaching is now below an acceptable level for safe practice. Junior doctors share similar concerns, indicating that a much greater emphasis should be placed on this aspect of the medical curriculum. Our primary aim was to assess the knowledge of peripheral nerve function in junior medical staff. This has not been previously examined. Our secondary aim was to assess participant’s satisfaction with medical school anatomy teaching.
Clinicopathologic correlations of renal pathology in Spain.

BACKGROUND There are not enough large epidemiologic population-based studies of biopsy-proven nephropathies with detailed clinicopathologic correlations. METHODS The Glomerulonephritis Registry of the Spanish Society of Nephrology has obtained data from 9378 cases with native biopsy-proven renal diseases and well-known clinical syndrome between 1994 and 2001, investigating clinicopathologic correlations. Patients were divided in three groups according to age: children (<15 years old), adults (15 to 65 years), and elderly (>65 years). RESULTS The most common clinical syndrome at any age is nephrotic syndrome (35.5%), followed by asymptomatic urinary abnormalities (25.9%), acute renal failure (12.9%), chronic renal failure (12.1%), nephritic syndrome (4.5%), macroscopic haematuria (4.5%), and arterial hypertension (3.0%). A male predominance is observed at any age (3:2). The frequencies of histologic findings are statistically different in all syndromes according to age. Minimal change disease is the most frequent finding in children with nephrotic syndrome (39.5%), whereas in adults and elderly, membranous nephropathy is the most prevalent (24.2% and 28.0%, respectively). Ig A nephropathy (IgAN) is the most frequent glomerulonephritis in patients with asymptomatic urinary abnormalities at any age. Acute renal failure is an important cause for performing a kidney biopsy in elderly and vasculitis is the main histologic finding. The clinical manifestations of focal segmental glomerulosclerosis, non-IgA mesangial nephropathy, lupus nephritis, vasculitis, and nephroangiosclerosis are statistically different according to age. CONCLUSION The findings of clinicopathologic correlations obtained from the Spanish Registry of Glomerulonephritis on native biopsy-proven renal diseases add valuable information to previous reports and it can be the initial step for follow-up and prospective studies.