Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficacy of Cognitive-Behavioral Therapy for Comorbid Panic Disorder With Agoraphobia and Generalized Anxiety Disorder

The goal of this study was to evaluate the efficacy of cognitive-behavioral therapy for comorbid panic disorder with agoraphobia (PDA) and generalized anxiety disorder (GAD) by combining treatment strategies for both disorders. A single-case, multiple-baseline design across participants was used. Three participants with primary PDA and secondary GAD took part in the study. The efficacy of the treatment was assessed by means of a structured interview, self-administered questionnaires, and daily self-monitoring measures. After treatment, 2 of the 3 participants achieved high end-state functioning and maintained this level of functioning at 3-, 6-, and 12-month follow-ups. The third participant also improved but only reached high end-state functioning at 6-month follow-up. It therefore appears that the combined treatment is relatively effective for PDA–GAD comorbidity. Possible avenues for improving the treatment are suggested.
Ross Kemp On Afghanistan

Ross Kemp risks all to tell the story of the British soldier in "Ross Kemp on Afghanistan". He has played an East End hardman, an SAS soldier and investigated vicious world gangs. Now Ross Kemp is taking on perhaps his hardest assignment of all - the Taliban. In order to prepare for this life-threatening ordeal, Ross Kemp trains with the First Battalion Royal Anglians in England's subzero temperatures, practicing firing SA 80 rifles and . 50 calibre machine guns, getting to know the soldiers and learning the tactics they use to stay alive. Sent with them to Camp Bastion in Afghanistan's Helmand province, he immerses himself fully: he endures the stifling heat, the constant threat of snipers, RPG attacks, suicide bombers and land mines. In short, he discovers first hand what it's like to fight on the frontline. It's the closest he's ever come to dying - bullets fizzing inches from his head as they hit the ground on either side of him. After two harrowing and arduous months Ross returns to England, but there is little relief to be had as he meets the mothers of soldiers killed in the conflict. Then in September 2008 he goes back to the war zone, to see how the men he grew so close to are faring, to check how many of them are still alive. "Ross Kemp on Afganistan" is a fascinating, horrifying and often moving insight into the brutal reality ordinary soldiers have to face in one of the world's most dangerous and volatile regions. Ross Kemp was born in Essex in 1964, to a father who was a senior detective with the Metropolitan Police and had served in the army for four years. He is a BAFTA award-winning actor, journalist and author, who is best known for his role of Grant Mitchell in "Eastenders". His award-winning documentary series "Ross Kemp on Gangs" led to his international recognition as an investigative journalist.
Organisation des assemblages demersaux dans le golfe du lion : structures spatiales et stabilite temporelle

L'analyse de l'organisation des assemblages demersaux du golfe du lion, a plusieurs echelles spatiales et temporelles, s'appuie sur les resultats de deux series de campagnes de chalutages d'evaluation directe entreprises entre 1983 et 1992. La mise en oeuvre de techniques recentes d'analyses de donnees multivariees, peu employees en ecologie, a permis une etude detaillee des structures spatiales et de leur stabilite dans le temps. Nos resultats montrent que les assemblages demersaux du golfe du lion presentent une forte structuration spatiale, principalement orientee selon un gradient d'eloignement a la cote. La grande stabilite temporelle des principales structures spatiales, observee a plusieurs echelles, suggere un fort determinisme de l'organisation de ces assemblages d'especes. Les facteurs d'origine abiotique (bathymetrie, caracteristiques de l'habitat, influence rhodanienne, upwellings) semblent jouer un role preponderant dans la formation et le maintien des assemblages demersaux de cette region. De plus, la mise en evidence d'une organisation spatiale simple et tres stable peut contribuer a alleger les plans d'echantillonnage, et a reduire le cout des campagnes d'evaluation directe. Enfin, en proposant une technique couplant les logiques de l'analyse des correspondances (afc) et celle de statis, cette etude a permis d'enrichir le champ d'application de la famille des analyses a tableaux multiples. Cette technique fournit une representation synthetique de la dynamique spatio-temporelle des assemblages d'especes. Elle rend possible l'apprehension simultanee, dans un referentiel unique, des notions de persistance, de resistance, de resilience et de variabilite, des populations et des peuplements.
The assessment of body image investment: an extensive revision of the appearance schemas inventory.

OBJECTIVE The Appearance Schemas Inventory (ASI) is a 14-item instrument that assesses body image investment in relation to certain beliefs or assumptions about the importance, meaning, and influence of appearance in one's life. Despite empirical support of the ASI, critical examination evinces several limitations of this assessment. These problems entail the inclusion of explicitly self-evaluative items and social stereotypes, few behavioral items, and a repeated failure to find expected gender differences on the ASI. METHOD We initially constructed a 45-item measure (40 new items plus 5 original items) and administered it, along with the original ASI and other validational assessments, to 603 college students (468 women and 135 men). RESULTS The end result was a 20-item revision of the inventory (ASI-R), which included two factors: Self-Evaluative Salience and Motivational Salience. For both genders, the composite ASI-R and its two factors had high internal consistency and were significantly convergent with other pertinent measures of body image and psychosocial functioning. The ASI-R and its two subscales showed significant gender differences, whereas the original ASI did not. We also examined racial differences on the ASI-R, its correlations with body mass, and its unique contribution to the prediction of disturbed eating attitudes. DISCUSSION We offer this measure as an improved, psychometrically sound replacement for the ASI.
Comparison of the nutritive value for laying hens of diets containing azolla ( Azolla pinnata ) based on formulation using digestible protein and digestible amino acid versus total protein and total amino acid

Azolla (Azolla pinnata) was assessed for nutrient content and feeding value in laying hen diets. Proximate analysis, together with the estimates of digestible protein, ADF, NDF and metabolizable energy indicated that it was a fair source of plant protein (285.4 g kgÿ1) with a digestible protein value of 219.8 g kgÿ1 and a metabolizable energy value of 7.59 MJ kgÿ1 (906 g kgÿ1 DM). The feeding value of azolla in laying hens was studied in two feeding trials of 16 and 8 weeks duration, respectively. Azolla meal was included at a level of 50 or 100 g kgÿ1 diet at the expense of sesame meal in diets formulated on a total protein and total amino acid, or digestible protein and digestible amino acid basis (Trial 1). In Trial 2, 150 and 200 g kgÿ1 azolla meal was included in diets formulated using a total protein and total amino acid, or digestible protein and digestible amino acid basis. L-lysine HCl and DL-methionine were added to the diets formulated using digestible nutrients to adjust the digestible lysine and methionine contents to those in the wheat sesame meal based control diet. It was found that azolla meal could replace sesame meal on a digestible protein and digestible amino acid basis up to 200 g kgÿ1 diet with egg production as the parameter, while it could replace only up to 150 g kgÿ1 sesame meal in the diet based on total protein and total amino acids. Egg mass output and feed conversion ratio were significantly better with up to 200 g kgÿ1 azolla meal in the diet when included on a digestible protein and digestible amino acid basis but not when the diets were formulated on a total protein and total amino acid basis. Feeding azolla on a digestible protein Animal Feed Science and Technology
Tumor Localization of 16β-18F-Fluoro-5α-Dihydrotestosterone Versus 18F-FDG in Patients with Progressive, Metastatic Prostate Cancer

This trial was an initial assessment of the feasibility, in vivo targeting, and biokinetics of 16β- 1 8 F-fluoro-5α-dihydrotestosterone ( 1 8 F-FDHTI PET in patients with metastatic prostate cancer to assess androgen receptor expression. Methods: Seven patients with progressive clinically metastatic prostate cancer underwent 1 8 F-FDG and 1 8 F-FDHT PET scans in addition to conventional imaging methods. Three patients had their studies repeated 1 mo later, 2 while on testosterone therapy, and the third after treatment with 17-allylamino-17-demethoxygeldanamycin (17-RAG). High-pressure liquid radiochromatography was used to separate 1 8 F-FDHT from radiolabeled metabolites. Lesion-by-lesion comparisons between the 1 8 F-FDHT, 1 8 F-FDG, and conventional imaging methods were performed. Results: Metabolism of 1 8 F-FDHT was rapid, with 80% conversion within 10 min to radiolabeled metabolites that circulated bound to plasma proteins. Tumor uptake was rapid and tumor retention was prolonged. Fifty-nine lesions were identified by conventional imaging methods. 1 8 F-FDG PET was positive in 57 of 59 lesions (97%), with an average lesion maximum standardized uptake value (SUV m a x ) = 5.22. 1 8 F-FDHT PET was positive in 46 of 59 lesions (78%), with the average positive lesion SUV m a x = 5.28. Treatment with testosterone resulted in diminished 1 8 F-FDHT uptake at the tumor site. Conclusion: 1 8 F-FDHT localizes to tumor sites in patients with progressive clinically metastatic prostate cancer and may be a promising agent to analyze antigen receptors and their impact on the clinical management of prostate cancer.
COLLECTIVE SHAME AND THE POSITIONING OF GERMAN NATIONAL IDENTITY

Uno de los temas centrales de la identidad en los jovenes alemanes es el sentimiento de culpa o verguenza colectiva por los crime­nes del Tercer Reich. Un estudio en la ante­rior Alemania Oriental y Occidental revelan un modelo complejo de aceptacion y rechazo de este pasado historico. Para examinar la relacion de la tercera generacion con el pasado Nazi se propuso un modelo teorico de verguenza colectiva. La experiencia de verguenza de­pen­de de los efectos de audiencia y se in­terpretaba como una forma de posicionamiento de identidad. La verguenza se relaciono negativamente con distintos indicadores de identidad nacional y autoestima co­lectiva, y positivamente con el deseo de re­parar el pasado. En conjunto, los analisis de ecuacion estructural indican que la autoestima colectiva (o identidad social) mas que la verguenza colectiva era la fuerza impulsora que marca el modelo global de relaciones entre las variables. Los resultados se interpretan desde la teoria de la identidad social para proporcionar un marco de comprension del posicionamiento histo­rico de la identidad nacional, autoestima colectiva y verguenza de colectividad.
Control functions of adenovirus transformation region E1A gene products in rat and human cells

Altered control of the rat cell cycle induced by adenovirus requires expression of transformation region E1A, but not of E1B, E2A, E2B, or late genes. We show here that neither E3 nor E4 is required, so the effect results directly from an E1A product. Mutants with defects in the 289-amino-acid (aa) E1A product had little or no effect on the rat cell cycle even at 1,000 IU per cell. A mutant (pm975) lacking the 243-aa E1A product altered cell cycle progression, but less efficiently than did wild-type virus. The 289-aa E1A protein is therefore essential for cell cycle effects; the 243-aa protein is also necessary for the full effect but cannot act alone. Mutants with altered 289-aa E1A proteins showed different extents of leak expression of viral early region E2A as the multiplicity was increased; each leaked more in human than in rat cells. dl312, with no E1A products, failed to produce E2A mRNA or protein at 1,000 IU per cell in rat cells but did so in some experiments in human cells. There appears to be a very strict dependence of viral early gene expression on E1A in rat cells, whereas dependence on E1A is more relaxed in HeLa cells, perhaps due to a cellular E1A-like function. Altered cell cycle control is more dependent on E1A function than is early viral gene expression.
Spontaneous axial myopia and emmetropization in a strain of wild-type guinea pig (Cavia porcellus).

PURPOSE To describe a wild-type guinea pig strain with an incidence of spontaneous axial myopia, minimal pupil responses, lack of accommodation, and apparently normal spatial vision. Such a strain is of interest because it may permit the exploration of defective emmetropization and mapping of the underlying quantitative trait loci. METHODS Twenty-eight guinea pigs were selected from 220 animals based on binocular myopia (exceeding -1.50 diopter [D]) or anisometropia (difference between both eyes exceeding 10 D) at 4 weeks of age. Refractions and pupil responses were measured with eccentric infrared photoretinoscopy, corneal curvature by modified conventional keratometer, and axial lengths by A-scan ultrasonography once a week. Twenty-one guinea pigs were raised under a normal 12-hour light/12-hour dark cycle. From a sample of 18 anisometropic guinea pigs, 11 were raised under normal light cycle and 7 were raised in the dark to determine the extent to which visual input guides emmetropization. Spatial vision was tested in an automated optomotor drum. RESULTS In 10 guinea pigs with myopia in both eyes, refractive errors ranged from -15.67 D to -1.50 D at 3 weeks with a high interocular correlation (R = 0.82); axial length and corneal curvature grew almost linearly over time. Strikingly, two patterns of recovery were observed in anisometropic guinea pigs: in 12 (67%) anisometropia persisted, and in 6 (33%) it declined over time. These ratios remained similar in dark-reared guinea pigs. Unlike published strains, all guinea pigs of this strain showed weak pupil responses and no signs of accommodation but up to 3 cyc/deg of spatial resolution. CONCLUSIONS This strain of guinea pigs has spontaneous axial refractive errors that may be genetically or epigenetically determined. Interestingly, it differs from other published strains that show no refractive errors, vivid accommodation, or pupil responses.
Study of Improved RSS Algorithm for Ultrasonic Array Applied to PD Location in Transformer

An improved rotated sub-space (RSS) algorithm is proposed for the application of array technology in partial discharge (PD) location in transformer. The algorithm is based on classic RSS algorithm and high-order cumulants, and it is studied through numerical simulation and experimental tests. Based on an L-shaped and a cross-shaped array, the simulation of single and multiple PD source direction is carried out to compare the classic RSS algorithm with improved RSS algorithm. The results confirm the processing capacity in wideband focus, aperture expansion, enhance of directing, and noise suppression of improved RSS algorithm. Moreover, both algorithms are used for PD location experiments, showing that the error of improved RSS algorithm is ~3°. Improved RSS algorithm solves the problem of wideband focusing in PD location, enhances the performance of the array aperture and directing, achieves the effect of the array consists of much more elements with a virtual expansion, simplifying the follow-up circuit.
Replica exchange with nonequilibrium switches

We introduce a replica exchange (parallel tempering) method in which attempted configuration swaps are generated using nonequilibrium work simulations. By effectively increasing phase space overlap, this approach mitigates the need for many replicas. We illustrate our method by using a model system and show that it is able to achieve the computational efficiency of ordinary replica exchange, using fewer replicas.
Prescribed Performance Output Feedback Control: An approximate passivation approach

In this paper we address the Prescribed Performance Control problem for uncertain MIMO systems, through output feedback. In order to do so, we exploit the feedback passivation approach according to which a system is rendered passive with the use of an output feedback control law. Using a two phase controller design procedure we guarantee convergence of the output tracking error to a predefined arbitrarily small residual set, with rate no less than a prespecified value, exhibiting a maximum overshoot less than a sufficiently small constant. Moreover, all other signals in the closed loop are kept bounded. To avoid possible division by zero, the output feedback passivation controller is of switching type.
Synaptic evidence for the efficacy of spaced learning

The superiority of spaced vs. massed training is a fundamental feature of learning. Here, we describe unanticipated timing rules for the production of long-term potentiation (LTP) in adult rat hippocampal slices that can account for one temporal segment of the spaced trials phenomenon. Successive bouts of naturalistic theta burst stimulation of field CA1 afferents markedly enhanced previously saturated LTP if spaced apart by 1 h or longer, but were without effect when shorter intervals were used. Analyses of F-actin-enriched spines to identify potentiated synapses indicated that the added LTP obtained with delayed theta trains involved recruitment of synapses that were “missed” by the first stimulation bout. Single spine glutamate-uncaging experiments confirmed that less than half of the spines in adult hippocampus are primed to undergo plasticity under baseline conditions, suggesting that intrinsic variability among individual synapses imposes a repetitive presentation requirement for maximizing the percentage of potentiated connections. We propose that a combination of local diffusion from initially modified spines coupled with much later membrane insertion events dictate that the repetitions be widely spaced. Thus, the synaptic mechanisms described here provide a neurobiological explanation for one component of a poorly understood, ubiquitous aspect of learning.
A Review of Measles

Measles, once a common childhood illness that many older school nurses could recognize without difficulty, needs review again after reemerging from Europe and other continents. A highly contagious disease, which has been referenced since the seventh century, the virus can cause serious illness and death, despite the fact that it is vaccine preventable. School nurses are wise to review the pathogenesis, occurrences, incubation, and communicability as well as methods to diagnose and treat measles in order to prevent an outbreak.
Pretreatment of isolated adult islets with antibody. Effect on survival in allogeneic hosts.

les cellules β pancreatiques ne presentant pas d'antigenes de classe II, le traitement des ilots par anticorps anti-classe II ne deteriore pas ces cellules. Les ilots traites par ces anticorps et par serum anti-lymphocytes avant d'etre transplantes chez un hote allogenique survivent un peu plus longtemps et leur rejet est plus tardif
Loss of single immunoglobulin interlukin-1 receptor-related molecule leads to enhanced colonic polyposis in Apc(min) mice.

BACKGROUND & AIMS Commensal bacteria can activate signaling by the Toll-like and interleukin-1 receptors (TLR and IL-1R) to mediate pathogenesis of inflammatory bowel diseases and colitis-associated cancer. We investigated the role of the single immunoglobulin IL-1 receptor-related (SIGIRR) molecule, a negative regulator of TLR and IL-1R signaling, as a tumor suppressor to determine whether SIGIRR controls cell-cycle progression, genetic instability, and colon tumor initiation by modulating commensal TLR signaling in the gastrointestinal tract. METHODS We analyzed adenomatous polyposis coli (Apc)min/+/Sigirr-/- mice for polyps, microadenomas, and anaphase bridge index. Commensal bacteria were depleted from mice with antibiotics. Akt, mammalian target of rapamycin (mTOR), and beta-catenin pathways were examined by immunoblotting and immunohistochemistry. Loss of heterozygosity of Apc and expression of cytokines and proinflammatory mediators were measured by nonquantitative or quantitative polymerase chain reaction. RESULTS Apcmin/+/Sigirr-/- mice had increased loss of heterozygosity of Apc and microadenoma formation, resulting in spontaneous colonic polyposis, compared with Apcmin/+/Sigirr+/+ mice. The increased colonic tumorigenesis that occurred in the Apcmin/+/Sigirr-/- mice depended on the presence of commensal bacteria in the gastrointestinal tract. Cell proliferation and chromosomal instability increased in colon crypt cells of the Apcmin/+/Sigirr-/- mice. Akt, mTOR, and their substrates were hyperactivated in colon epithelium of Apcmin/+/Sigirr-/- mice in response to TLR or IL-1R ligands. Inhibition of the mTOR pathway by rapamycin reduced formation of microadenomas and polyps in the Apcmin/+/Sigirr-/- mice. CONCLUSIONS SIGIRR acts as a tumor suppressor in the colon by inhibiting TLR-induced, mTOR-mediated cell-cycle progression and genetic instability.
Does job crafting assist dealing with organizational changes due to austerity measures? Two studies among Greek employees

ABSTRACT In this paper, we focussed on Greek employees that are heavily affected by austerity-led organizational changes, and studied whether job crafting (defined as seeking resources, seeking challenges, reducing demands) helps them deal with these changes. In the first, cross-sectional study we examined whether job crafting relates to adaptive performance, and whether individuals’ assessment of changes moderates this relationship. The results showed that the relationship between reducing demands and adaptive performance was positive for those assessing the changes more positively, and negative for those assessing them more negatively. This interaction was replicated in the second, quasi-experimental field study, where we examined the effects of an intervention designed to help employees deal with organizational changes and increase their well-being, adaptive performance and openness to such changes by stimulating job crafting behaviours. Participants received training and worked for 3 weeks on self-set job crafting goals. The intervention was effective in increasing reducing demands, positive affect and openness to change. Moreover, it had a positive effect on openness to change and adaptive performance through positive effect, but a negative effect on adaptive performance through reducing demands. Thus, the intervention facilitated to some extent employee functioning under unfavourable working conditions that result from austerity measures.
The IRM Fluxgate Magnetometer

This report describes the three-axis fluxgate magnetometer instrument on board the AMPTE IRM spacecraft. Important features of the instrument are its wide dynamic range (0.1-60 000 nT), a high resolution (16-bit analog to digital conversion) and the capability to operate automatically or via telecommand in two gain states. In addition, the wave activity is monitored in all three components up to 50 Hz. Inflight checkout proved the nominal functioning of the instrument in all modes.