Miracle-dz/UniFAR-FTUs huggingface dataset:
A2-Nets: Double Attention Networks

Learning to capture long-range relations is fundamental to image/video recognition. Existing CNN models generally rely on increasing depth to model such relations which is highly inefficient. In this work, we propose the "double attention block", a novel component that aggregates and propagates informative global features from the entire spatio-temporal space of input images/videos, enabling subsequent convolution layers to access features from the entire space efficiently. The component is designed with a double attention mechanism in two steps, where the first step gathers features from the entire space into a compact set through second-order attention pooling and the second step adaptively selects and distributes features to each location via another attention. The proposed double attention block is easy to adopt and can be plugged into existing deep neural networks conveniently. We conduct extensive ablation studies and experiments on both image and video recognition tasks for evaluating its performance. On the image recognition task, a ResNet-50 equipped with our double attention blocks outperforms a much larger ResNet-152 architecture on ImageNet-1k dataset with over 40% less the number of parameters and less FLOPs. On the action recognition task, our proposed model achieves the state-of-the-art results on the Kinetics and UCF-101 datasets with significantly higher efficiency than recent works.
Regulatory T Cells Suppress Effector T Cell Proliferation by Limiting Division Destiny

Understanding how the strength of an effector T cell response is regulated is a fundamental problem in immunology with implications for immunity to pathogens, autoimmunity, and immunotherapy. The initial magnitude of the T cell response is determined by the sum of independent signals from antigen, co-stimulation and cytokines. By applying quantitative methods, the contribution of each signal to the number of divisions T cells undergo (division destiny) can be measured, and the resultant exponential increase in response magnitude accurately calculated. CD4+CD25+Foxp3+ regulatory T cells suppress self-reactive T cell responses and limit pathogen-directed immune responses before bystander damage occurs. Using a quantitative modeling framework to measure T cell signal integration and response, we show that Tregs modulate division destiny, rather than directly increasing the rate of death or delaying interdivision times. The quantitative effect of Tregs could be mimicked by modulating the availability of stimulatory co-stimuli and cytokines or through the addition of inhibitory signals. Thus, our analysis illustrates the primary effect of Tregs on the magnitude of effector T cell responses is mediated by modifying division destiny of responding cell populations.
Rapid quantitative analysis of etoricoxib in human plasma by UPLC-MS/MS and application to a pharmacokinetic study in Chinese healthy volunteers.

A selective and sensitive liquid chromatography-tandem mass spectrometry method was developed for simultaneous determination of etoricoxib in human plasma. Chromatography was performed on an Acquity UPLC HSS T3 column (1.8 μm, 50 × 2.1 mm), with a flow rate of 0.600 mL/min, using a gradient elution with acetonitrile and water which contained 2 mm ammonium acetate as the mobile phase. Detection was carried out on Triple QuadTM 5500 mass spectrometer under positive-ion multiple reaction monitoring mode. The respective mass transitions used for quantification of etoricoxib and etoricoxib-d3 were m/z 359.0 → 280.1 and m/z 362.0 → 280.2. Calibration curves were linear over the concentration range of 5-5000 ng/mL. The validated method was applied in the pharmacokinetic study of etoricoxib in Chinese healthy volunteers under fed and fasted conditions. After a single oral dose of 120 mg, the main pharmacokinetic parameters of etoricoxib in fasted and fed groups were respectively as follows: peak concentration, 2364.78 ± 538.01 and 1874.55 ± 367.90 ng/mL; area under the concentration-time curve from 0 to 120 h, 44,605.53 ± 15,266.66 and 43,516.33 ± 12,425.91 ng h/mL; time to peak concentration, 2.00 and 2.50 h; and half-life, 24.08 ± 10.06 and 23.64± 6.72 h. High-fat food significantly reduced the peak concentration of etoricoxib (p = 0.001) but had no effect on the area under the concentration-time curve.
Propiedades psicométricas de una versión en español del Experiences in Close Relationships-Revised (ECR-R)

El objetivo de esta investigación fue explorar las evidencias de validez de estructura interna y convergente, así como la confiabilidad de la escala Experiences in Close Relationships-Revised (ECR-R) en estudiantes universitarios peruanos. Para ello, se realizó de manera secuencial del análisis factorial exploratorio y del análisis factorial confirmatorio en dos subgrupos aleatoriamente determinados (n = 289, n = 301). El análisis paralelo de Horn y los resultados del análisis factorial exploratorio realizado con el primer subgrupo encontró una estructura de tres factores reproduciendo las dimensiones de ansiedad y evitación medida de manera directa y de manera inversa. El análisis factorial confirmatorio realizado con el segundo subgrupo confirmó la existencia de un modelo de tres factores con índices de ajuste aceptables. Cada una de las dimensiones demostró consistencia interna adecuada de acuerdo con el alfa de Cronbach. Los resultados apoyan parcialmente la validez convergente del ECR-R con el Relationship Questionnaire. Al final de los análisis realizados, se presenta una versión de 27 ítems con evidencias aceptables de validez de estructura interna y convergente.
Effect of Artificial LED Light and Far Infrared Irradiation on Phenolic Compound, Isoflavones and Antioxidant Capacity in Soybean (Glycine max L.) Sprout

The effect of light emitting diode (LED) light and far infrared irradiation (FIR) on total phenol, isoflavones and antioxidant activity were investigated in soybean (Glycine max L.) sprout. Artificial blue (470 nm), green (530 nm) LED and florescent light (control) were applied on soybean sprout, from three to seven days after sowing (DAS) in growth chamber. The photosynthetic photon flux density (PPFD) and photoperiod was 150 ± 5 μmol m−2s−1 and 16 h, respectively. The FIR was applied for 30, 60 and 120 min at 90, 110 and 130 °C on harvested sprout. Total phenolic content (TP) (59.81 mg/g), antioxidant capacity (AA: 75%, Ferric Reduction Antioxidant Power (FRAP): 1357 µM Fe2+) and total isoflavones content (TIC) (51.1 mg/g) were higher in blue LED compared to control (38.02 mg/g, 58%, 632 µM Fe2+ and 30.24 mg/g, respectively). On the other hand, TP (64.23 mg/g), AA (87%), FRAP (1568 µM Fe2+) and TIC (58.98 mg/g) were significantly increased by FIR at 110 °C for 120 min among the treatments. Result suggests that blue LED is the most suitable light to steady accumulation of secondary metabolites (SM) in growing soybean sprout. On the other hand, FIR at 110 °C for 120 min is the best ailment to induce SM in proceed soybean sprout.
First Monte Carlo Global QCD Analysis of Pion Parton Distributions.

We perform the first global QCD analysis of parton distribution functions (PDFs) in the pion, combining πA Drell-Yan data with leading neutron electroproduction from HERA within a Monte Carlo approach based on nested sampling. Inclusion of the HERA data allows the pion PDFs to be determined down to much lower values of x, with relatively weak model dependence from uncertainties in the chiral splitting function. The combined analysis reveals that gluons carry a significantly higher pion momentum fraction, ∼30%, than that inferred from Drell-Yan data alone, with sea quarks carrying a somewhat smaller fraction, ∼15%, at the input scale. Within the same effective theory framework, the chiral splitting function and pion PDFs can be used to describe the d[over ¯]-u[over ¯] asymmetry in the proton.
Persistent or recurrent symptoms after arthroscopic surgery for femoroacetabular impingement: A review of imaging findings

Hip arthroscopy is one of the most rapidly growing and evolving orthopaedic subspecialties. With the recent dramatic increase in the volume of hip arthroscopy performed there has been an increase in the number of symptomatic patients following arthroscopy for femoroacetabular impingement. Imaging has a key role in determining the need for revision surgery and in preoperative planning. Although the revision rate for hip arthroscopy is 3–9%, little has been published about the imaging findings associated with unsatisfactory treatment outcomes. This review discusses the significance of pre‐existing osteoarthritis and underlying hip dysplasia and describes the causes of persistent symptoms. Recent literature on extra articular impingement and causes of microinstability are presented. Post‐operative appearances are described focussing on the clinically relevant imaging findings. The challenges of evaluating the labrum after repair and specific findings associated with anchor failure and iatrogenic chondrolabral injury are discussed. The purpose of this article is to review the causes of unsatisfactory treatment outcomes after hip arthroscopy, role of imaging and indications for revision arthroscopy.
Funding and policy incentives to encourage implementation of point-of-care C-reactive protein testing for lower respiratory tract infection in NHS primary care: a mixed-methods evaluation

Objectives Utilisation of point-of-care C-reactive protein testing for lower respiratory tract infection has been limited in UK primary care, with costs and funding suggested as important barriers. We aimed to use existing National Health Service funding and policy mechanisms to alleviate these barriers and engage with clinicians and healthcare commissioners to encourage implementation. Design A mixed-methods study design was adopted, including a qualitative survey to identify clinicians’ and commissioners’ perceived benefits, barriers and enablers post-implementation, and quantitative analysis of results from a real-world implementation study. Interventions We developed a funding specification to underpin local reimbursement of general practices for test delivery based on an item of service payment. We also created training and administrative materials to facilitate implementation by reducing organisational burden. The implementation study provided intervention sites with a testing device and supplies, training and practical assistance. Results Despite engagement with several groups, implementation and uptake of our funding specification were limited. Survey respondents confirmed costs and funding as important barriers in addition to physical and operational constraints and cited training and the value of a local champion as enablers. Conclusions Although survey respondents highlighted the clinical benefits, funding remains a barrier to implementation in UK primary care and appears not to be alleviated by the existing financial incentives available to commissioners. The potential to meet incentive targets using lower cost methods, a lack of policy consistency or competing financial pressures and commissioning programmes may be important determinants of local priorities. An implementation champion could help to catalyse support and overcome operational barriers at the local level, but widespread implementation is likely to require national policy change. Successful implementation may reproduce antibiotic prescribing reductions observed in research studies.
Egocentric bias across mental and non-mental representations in the Sandbox Task

In the Sandbox Task, participants indicate where a protagonist who has a false belief about the location of an object will look for that object in a trough filled with a substrate that conceals the hidden object’s location. Previous findings that participants tend to indicate a location closer to where they themselves know the object to be located have been interpreted as evidence of egocentric bias when attributing mental states to others. We tested the assumption that such biases occur as a result of reasoning about mental states specifically. We found that participants showed more egocentric bias when reasoning from a protagonist’s false belief than from their own memory, but found equivalent levels of bias when they were asked to indicate where a false film would depict the object as when they were asked about a protagonist’s false belief. Our findings suggest that that egocentric biases found in adult false belief tasks are more likely due to a general difficulty with reasoning about false representations than a specialised difficulty with reasoning about false mental states.
Learning to Actively Learn Neural Machine Translation

Traditional active learning (AL) methods for machine translation (MT) rely on heuristics. However, these heuristics are limited when the characteristics of the MT problem change due to e.g. the language pair or the amount of the initial bitext. In this paper, we present a framework to learn sentence selection strategies for neural MT. We train the AL query strategy using a high-resource language-pair based on AL simulations, and then transfer it to the low-resource language-pair of interest. The learned query strategy capitalizes on the shared characteristics between the language pairs to make an effective use of the AL budget. Our experiments on three language-pairs confirms that our method is more effective than strong heuristic-based methods in various conditions, including cold-start and warm-start as well as small and extremely small data conditions.
Mediating Factors in Early Diagnosis of Breast Cancer: from Initial Changes in Health to Breast Cancer Detection

Background: Breast cancer is one of the most frequently occurring cancers in women throughout the world. In Iran, according to available reports, 70% of patients with breast cancer are detected at the advanced stages of the disease. Materials and Methods: This study is of descriptive-analytic cross-sectional type.160 female patients was selected. The data in this study was collected via face to face interview using a questionnaire based on the Anderson’s delay model. Data were analyzed using SPSS 22 and the significance level was considered to be 0.05. Results: The results showed that presence of mass was the first symptom in many of women, i.e., 76 cases (47.5%). not only the presence of mass in the breast, but also any other symptom, hadn’t been taken as a serious problem initially by women. Non-improvement of the symptoms and exacerbation of the symptoms was considered as a symptom of illness by patients. After considering the changes as the symptoms of illness, patients had tried to treat the disease through different methods of self-treatment. The failure of the self-treatment in controlling the symptoms, had directed the patients toward seeking for medical services. Out of 160 patients, 49 patients (39.6%) changed the time of their appointment with doctor. 110 cases (68%) out of 160 patients, rather than initiating relevant diagnostic procedure related to the disease, had received non-specific and non-related therapeutic measures. Conclusion: Pondering on the results yields that patient-related delays, resulting from their lack of awareness of the disease, cultural factors, and fear, can only play an important role in postponement of visiting a physician, but in the diagnosis of disease it is the inability of general practitioners in performing differential diagnoses, and making request for related diagnostic measures which can significantly increase the lag time until the onset of the main treatment.
Commonsense Knowledge Base Completion and Generation

This study focuses on acquisition of commonsense knowledge. A previous study proposed a commonsense knowledge base completion (CKB completion) method that predicts a confidence score of for triplet-style knowledge for improving the coverage of CKBs. To improve the accuracy of CKB completion and expand the size of CKBs, we formulate a new commonsense knowledge base generation task (CKB generation) and propose a joint learning method that incorporates both CKB completion and CKB generation. Experimental results show that the joint learning method improved completion accuracy and the generation model created reasonable knowledge. Our generation model could also be used to augment data and improve the accuracy of completion.
Fast strategies in biased Maker-Breaker games

We study the biased $(1:b)$ Maker--Breaker positional games, played on the edge set of the complete graph on $n$ vertices, $K_n$. Given Breaker's bias $b$, possibly depending on $n$, we determine the bounds for the minimal number of moves, depending on $b$, in which Maker can win in each of the two standard graph games, the Perfect Matching game and the Hamilton Cycle game.
Hyperbaric oxygen affects endothelial progenitor cells proliferation in vitro

Hyperbaric oxygen is a clinical treatment that contributes to wound healing by increasing fibroblasts proliferation, collagen synthesis, and production of growth factors, inducing angiogenesis and inhibiting antimicrobial activity. It also has been shown that hyperbaric oxygen treatment (HBO), through the activation of nitric oxide synthase promotes an increase in the nitric oxide levels that may improve endothelial progenitor cells (EPC) mobilization from bone marrow to the peripheral blood and stimulates the vessel healing process. However, cellular mechanisms involved in cell proliferation and activation of EPC after HBO treatment remain unknown. Therefore, the present work aimed to analyze the effect of HBO on the proliferation of pre‐treated bone marrow‐derived EPC with TNF‐alpha. Also, we investigated the expression of ICAM and eNOS by immunochemistry, the production of reactive species of oxygen and performed an in vitro wound healing. Although 1h of HBO treatment did not alter the rate of in vitro wound closure or cell proliferation, it increased eNOS expression and decreased ICAM expression and reactive oxygen species production in cells pre‐treated with TNF‐alpha. These results indicate that HBO can decrease the inflammatory response in endothelial cells mediated by TNF‐alpha, and thus, promote vascular recovery after injury.
Respiratory Sinus Arrhythmia Quantified with Linear and Non-Linear Techniques to Classify Dilated and Ischemic Cardiomyopathy

In congestive heart failure (CHF), dilated cardiomyopathy (DCM) and ischemic cardiomyopathy (ICM) are two highly related pathologies that are not fully characterized. The aim of this study is to assess respiratory sinus arrhythmia (RSA) index of the parasympathetic system, in order to discriminate between both pathologies, DCM and ICM. For this, ECG-signals of 49 subjects (12 DCM patients, 21 ICM patients, 6 ICM patients with diabetes mellitus (DM) type II and 10 control subjects) from the database HERIS II and of 173 subjects (50 DCM, 50 ICM, 15 DCM with DM type II, 15 ICM with DM type II and 47 control subjects) from the database MUSIC2 were analyzed. The RSA was quantified using linear and non-linear analysis methods (fractal dimension and entropy). The results showed a significant difference between ICM and DCM subjects (p=0.013) with a sensitivity of 83% and specificity of 90%. Decreasing RSA values were present in CHF patients, especially in ICM patients, in comparison with healthy subjects. Alterations in the parasympathetic system due to DM were also identified.
Classification of sEMG Signals for the Detection of Vocal Fatigue based on VFI Scores

In this new research, we expand on our previous system for vocal fatigue detection by adding five new features in the classifier. We also perform further testing on 37 test subjects. The goals were: 1) to classify subjects performing normal versus simulated pressed vocal gestures; 2) to distinguish vocally healthy from vocally fatigued subjects as determined by VFI score on factor 1; and 3) to determine the validity of the labels vis-a-vis the choice of this same VFI-factor-1 boundary. As the results demonstrated, the choice of classifier and the new features were quite appropriate, while there is margin for better choices of the VFI-factor-1 boundary.
Placebo Effect in Obsessive-Compulsive Disorder (OCD). Placebo Response and Placebo Responders in OCD: The Trend Over Time

Background Placebo response appears to be increasing in antidepressant, antipsychotic and various internal medicine trials. A similar trend has been reported for OCD during 1989-1999. Placebo response is generally considered as the extent to which placebo treatment is associated with core symptom improvement. In this analysis, we used Joinpoint regression to assess the time trend of both placebo response and placebo responder rates according to the year of publication with no time restriction in OCD drug trials. Method We included drug and/or psychotherapy trials vs. placebo from PubMed, Embase, CINAHL, and PsycINFO retrieved through the search (placebo OR sham) AND (obsessive* OR OCD). We included studies through investigator consensus. We then performed on data of included studies log-linear joinpoint segmented regression models using a p<0.05 cutoff. Results We included 113 studies from 112 published papers. Placebo mean annual response rates in OCD studies significantly increased from 1991 to 2017 with an annual percent change (APC) of 0.66%, while placebo mean annual responder rates also significantly increased from 2010 to 2017, with an APC of 5.45%. Drug mean annual response rates in OCD studies significantly increased from 1987 to 2012 with an APC of 0.72%, while the corresponding responder rates did not show statistically significant APC changes between 1984 and 2017. Conclusion We observed a tendency for placebo to increase both measures of response in OCD clinical drug trials through the years that tend to approximate the responses shown by drugs. Changes in the type of study (moving from classical head to head comparisons to add-on studies in treatment-resistant populations) and countries involved in experimentation may partially account for some portion of these results. It appears that placebo effects are becoming more elusive and out of control.
Antibodies reacting to mimotopes of Simian virus 40 large T antigen, the viral oncoprotein, in sera from children

Recent data indicate that the Simian virus 40 (SV40) infection appears to be transmitted in humans independently from early SV40‐contaminated antipolio vaccines. Serum antibodies against SV40 large T antigen (Tag) were analyzed in children/adolescents and young adults. To investigate antibodies reacting to SV40 Tag antigens, serum samples ( n = 812) from children and young adults were analyzed by indirect ELISAs using specific SV40 Tag mimotopes. Mimotopes were synthetic peptides corresponding to SV40 Tag epitopes. In sera ( n = 412) from healthy children up to 17 years old, IgG antibodies against SV40 Tag mimotopes reached an overall prevalence of 15%. IgM antibodies against SV40 Tag were detected in sera of children 6–8 months old confirming and extending the knowledge that SV40 seroconversion occurs early in life. In children/adolescents affected by different diseases ( n = 180) SV40 Tag had a prevalence of 18%, being the difference no significant compared to healthy subjects ( n = 220; 16%) of the same age. Our immunological data indicate that SV40 circulates in children and young adults, both in healthy conditions and affected by distinct diseases. The IgM detection in sera from healthy children suggests that the SV40 infection/seroconversion occurs early in life (>6 months). Our immunological data support the hypothesis that SV40, or a closely related still unknown polyomavirus, infects humans. The SV40 seroprevalence is lower than common polyomaviruses, such as BKPyV and JCPyV, and other new human polyomaviruses. In addition, our immunological surveillance indicates a lack of association between different diseases, considered herein, and SV40.