Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of Response Scenarios to Potential Polio Outbreaks Using Mathematical Models

Appropriate response to polio outbreaks represents an important prerequisite for achieving and maintaining global polio eradication. We use an existing dynamic disease transmission model to evaluate the impact of different aspects of immunization campaigns in response to polio outbreaks occurring in previously polio‐free areas. This analysis yields several important insights about response strategies. We find that delay in response represents a crucial risk factor for occurrence of large outbreaks and we characterize the tradeoffs associated with delaying the initial response to achieve better population coverage. We also demonstrate that controlling most potential outbreaks will likely require at least three immunization rounds, although the impact of the optimal interval between rounds varies. Finally, long after oral poliovirus vaccine cessation the choice of target age groups during a response represents an important consideration.
Local Agenda 21 and Community Participation in Tourism Policy and Planning: Future or Fallacy

Turning from enunciation of sustainability to implementation, this paper focuses on the Local Agenda 21 (LA 21) policy envelope, emanating from the 1992 Rio Earth Summit. Agenda 21 challenges local authorities to adopt policy goals encompassing not only sustainable development but also to incorporate participative, collaborative processes, which involve local communities in defining their own sustainable futures. This can and should include tourism development as a significant environmental, economic and social agent. The impacts LA21 is having on tourism are assessed, using the UK as a case example, but with wider relevance. The paper evidences that while sustainable development in tourism practice is emerging, this remains largely outside the LA21 process, the significance of which and the relevance to tourism has been slow to be recognised. More attention to LA21's relevance to tourism is advocated and quintessentially sustainable forms of tourism development, such as cycle tourism initiatives, are use.
Growth and Technological Leadership in US Industries: A Spatial Econometric Analysis at the State Level, 1963-1997

For several decades, cross-country analyses have dominated the literature on economic growth. Recently, these analyses have been extended to include sectoral variation as well as spatial variation across sub-national regions. This paper investigates economic growth and potential determinants of the process of catch-up to technology leaders for several economic sectors, using data for the lower 48 US states from 1963 through 1997. We analyze the potential influence of factors such as human capital, and geographical distance to the technology leader. A spatially explicit growth model in which technological progress is endogenously determined is used to model productivity growth in nine US industries, ranging from mining to government, and including a combined sector of totals. The results indicate that none of the sectors exhibits convergence, but they all show strong evidence of convergence with a convergence club pattern that is apparent for the wholesale/retail sector. The catch-up effect to the technology leader dominates the growth process in almost all sectors, and it works through the interaction with human capital.
The Tax effects of inflation : depreciation, debt, and Miller's equilibrium tax rates

Indexing historical cost accounting to inflation has received considerable attention in the accounting literature. From a tax perspective, it is often argued that with historical cost accounting, inflation increases effective corporate tax rates, ceteris paribus. (See Davidson and Weil [1978], Williams [1979], Bernard [1981], and Gonedes [1981].)1 A major reason is the failure of historical cost accounting to index the depreciation tax shield to inflation. "But explicit indexation may not be necessary to achieve all the effects of indexation. The same effects can be attained, at least with respect to expected rates of inflation, if nominal interest rates incorporate unbiased forecasts of rates of inflation" (Gonedes [1981, p. 247]). 2 Davidson and Weil [1976] note that price-level adjusting the tax system would increase the depreciation tax shield, but it ". would diminish the tax-saving attribute of debt financing in a period of rising prices" [1976, p. 99].
Sensitization Input Vector Impact on Propagation Delay for Nanometer CMOS ICs: Analysis and Solutions

We report and analyze the dependence of complex gates delay with the sensitization vector and its variation-that gets up to 40% in 65-nm CMOS technologies-and include its effect in the path delay estimation-that can be in the order of 16%. The gate delay is computed from a simple polynomial analytical description that requires a one-time library parameter extraction process, making it highly scalable. An STA tool based on a single-pass true path computation is used to determine the critical path list. Since it does not rely on a two-step process, it can be programmed to find efficiently the N true paths from a circuit. Results from various benchmark circuits synthesized for three commercial technologies (130, 90, and 65 nm) provide better results in number of paths reported and delay estimation for these paths compared to a commercial tool. The impact of delay variation with the sensitization vector for paths with complex gates reveals as a significant mechanism that must be considered as it is comparable to the impact of parameter variations or interconnect-induced delay.
Does Financial Distress Risk Drive the Momentum Anomaly

"This paper brings together the evidence on two asset pricing anomalies-continuation of prior returns (momentum) and the market mispricing of distressed firms-using UK data. Our analysis demonstrates both these effects are driven by market underreaction to financial distress risk. In particular, we find momentum is proxying for distress risk, and is largely subsumed by our distress risk factor. We also find, as with US studies, no evidence that size and book-to-market (B/M) effects in stock returns are linked to financial distress". Copyright (c) 2008 Financial Management Association International.
Imagining penal policy for women: The case for Women's Community Services

The Women’s Community Services (WCSs) established in 2009 in England and Wales were based on the model of one-stop-shop, women-only provision endorsed by the 2007 Corston report. In this paper we discuss the development of WCSs as part of a governmental/voluntary sector initiative that was arguably an attempt to re-imagine penal policy for women offenders in the community, and explore themes emerging from interviews carried out with 30 women attending six WCSs between April 2011–2012. We argue that WCSs have filled a gap in provision for low risk women offenders by providing a range of social capital opportunities that are not available in mainstream, mixed-gender community punishment provision. We highlight the gendered processes of desistance; the understanding of which, we argue, is vital in making provision for women offenders in the new contracting landscape.
Work‐life balance initiatives: implications for women

This article uses evidence from a piece of action research conducted in the UK hospitality industry to explore the effectiveness of work‐life balance initiatives in helping women progress to senior management. It explores the main barriers to women's progression and highlights the long hours associated with managerial roles as a major problem. The article shows that the business case which underpins diversity management and a voluntary approach to work‐life balance may only deliver positive benefits to women when the labour market is tight, and, even then, the benefits for women in management are far from demonstrated. A stronger equal opportunities approach is also shown to be problematic as it draws attention to women's “difference” to men and their need for special treatment. Given the contingent nature of the business case, it is argued that a strong floor of rights is still needed to protect the most vulnerable employees, especially in an industry where trade unions have virtually no “voice”. It is further argued that more work needs to be done with male managers in order to humanise the workplace for men and women who wish to lead rounded lives.
An Exploratory Analysis of Women's Empowerment in India: A Structural Equation Modelling Approach

ABSTRACT The study is an exercise to explore possible directions of causation of level of women's empowerment, a latent variable, with related factors with the view to identify the causes of slow growth of it in India applying the ‘Structural Equation Modelling' (SEM) method to Third National Family and Health Survey data conducted during 2005–2006. The results recognise the inefficiency of education and employment policies formulated in India for women required to bring about behavioural changes among women to fight against the norms of patriarchal society. Significant regional variations are also observed. Priority should be given to an awareness campaigning programme to change social norms and the spread of education and information systems may play a significant role in doing so. The regulatory authority may involve non-governmental organisations (NGOs) in this context.
What Survey Data Reveal About Price and Wage Rigidity in Portugal

This paper exploits the information collected from a survey conducted on a sample of Portuguese firms to study the patterns of firms’ price and wage adjustments and the extent of nominal price and wage rigidities. The evidence shows that the frequency of price changes varies substantially across sectors and depends on the intensity of competition, the share of labor costs and firms’ price reviewing behavior. The results also suggest that the constraint imposed by the presence of downward nominal wage rigidity is less important in firms where the fraction of permanent and high-skilled workers is lower and the share of flexible pay components is higher.
N-Telopeptide of Type I Collagen Long-Term Dynamics in Breast Cancer Patients With Bone Metastases: Clinical Outcomes and Influence of Extraskeletal Metastases.

BACKGROUND Markers of bone metabolism, such as N-telopeptide of type I collagen (NTX), have been demonstrated to be prognostic in previous trials of breast cancer (BC) patients with bone metastases (BMs). In the present study, we tested the survival effect of the NTX response to zoledronic acid (ZA) at 3 and 12 months in a contemporaneous cohort of BC patients with BMs and evaluated the influence of extraskeletal metastatic disease on NTX variation. PATIENTS AND METHODS The present study was a prospective cohort study of consecutive BC patients diagnosed and treated at a single center. Patients presenting with de novo radiological evidence of BMs who started monthly intravenous ZA were included. Urinary NTX was measured at baseline and 1, 3, 6, 9, and 12 months after ZA introduction. RESULTS Overall, 71 patients were enrolled, 32 with BMs and 39 with BMs plus extraskeletal metastases. The proportion of patients with elevated NTX at baseline and 3 and 12 months was 49.3%, 26.6%, and 34.2%, respectively. The variables associated with survival included age at diagnosis, tumor estrogen receptor status, and NTX at 3 and 12 months. Multivariate analysis showed that, in addition to age at diagnosis, only the 3-month NTX level was significantly associated with survival. Patients with BMs plus extraskeletal metastases had an erratic NTX variation pattern, unrelated to survival. CONCLUSION In the present contemporaneous cohort of BC patients with BMs, the NTX response at 3 months was strongly associated with survival. Furthermore, an early response to ZA was strongly associated with long-term NTX control. Finally, patients with BMs plus extraskeletal metastases had an erratic NTX variation. IMPLICATIONS FOR PRACTICE The present study showed that when accommodating recent therapy innovations and longer patient survival, the N-telopeptide (NTX) variation at 3 months is strongly associated with survival. In this setting, in addition to a few other clinicopathological features, NTX is a powerful prognostic marker. Moreover, early NTX correction associates with persistently normal NTX. This might identify a subgroup of patients with a good prognosis who are eligible for premature zoledronic acid (ZA) de-escalation. Finally, patients with bone plus extraskeletal metastases showed an erratic variation of NTX, raising concerns that a single ZA regimen might not fit all patients. Future trials should test its effect according to the presence of extraskeletal involvement.
Caught in an evaluatory trap: a dilemma for public services under NPFM

This paper presents a challenge to public sector managers, policy-makers and interested academics. Drawing on the findings of previous international comparative studies of new public financial management (NPFM) reforms, it concludes that public services and their providers are caught in an ‘evaluatory trap’. The continual promotion of NPFM reforms, despite their evident repeated failure to meet specified achievements, is argued to be generating a cycle of ever-decreasing public services at ever-increasing costs per service unit. As the legitimacy of public services increasingly rests on the need to be seen as efficient and effective and as definitions of efficiency frequently demand adoption of the latest set of NPFM reforms, it follows that the future for public services is in question.
Testing Rational Expectations Hypothesis in the Manufacturing Sector in Malaysia

The application of rational expectations hypothesis (REH) in macroeconomic research has marked a revolution in economic thinking, and the magnitude of its impact on the world of economics is undeniably significant. However, the extent to which REH applies in real-world settings is ambiguous even though the concept of REH is well established in economics literature because empirical evidence from previous studies is clearly mixed. This study used survey data on gross revenue and capital expenditures to examine the validity of REH in Malaysian manufacturing business expectations. Empirical results indicated that the manufacturers’ expectations are being irrationally constructed in terms of gross revenue predictions but comply with REH properties in Muth's sense in the case of capital expenditures forecasts. Therefore, manufacturing firms in Malaysia are encouraged to incorporate more relevant information into their gross revenue predictions to provide more accurate and realistic forecasting.
EMPIRICAL INVESTIGATIONS INTO FIRM TECHNOLOGY ORIENTATION AND ENTREPRENEURIAL ORIENTATION

Entrepreneurship and its relation with technology is studied extensively within organizations and often conceptualized as entrepreneurial orientation (EO) and technology orientation (TO). This paper empirically tests the relationship between these orientations and firm performance by measuring how environmental dynamism and hostility may influence the EO–TO relationship. After providing an overview of the relevant variables, data are collected from 229 firms in Johannesburg, South Africa. Statistical analyses are employed to test the hypothesized associations. Findings reveal robust reliability and validity of scales used, and significant correlations between EO and environment hostility and dynamism are reported.
The Association between Auditor Quality and Auditor Size: An Analysis of Small CPA Firms

Prior research has documented a positive association between audit quality and auditor size. While some studies have used audit fee as a surrogate for audit quality, other studies have employed more direct measures, such as the outcomes of quality control reviews. Those latter studies, however, used samples that suffer from severe geographic or client-type restrictions. Moreover, most studies of the quality-size relationship have focused on relatively large CPA firms. The present study extends this literature by using a nationwide sample of 422 small CPA firms selected from the American Institute of Certified Public Accountants' (AICPA) Private Companies Practice Section peer review program, which provides comprehensive measures of CPA firm quality. This study also investigated (1) whether peer review ratings improve with successive reviews and (2) if oversight organization (the AICPA or state societies of CPAs) systematically affects peer review ratings. The results show that for firms that perform audits, reviews, and compilations (but not for firms that perform reviews and compilations, but no audits) auditor quality is positively associated with firm size, the number of previous reviews, and oversight by state societies. These findings suggest that (1) firm size is a useful quality surrogate only for firms that conduct audits, (2) the AICPA's peer review program has been successful in that firms improved their peer review ratings over time, and (3) state-society-sponsored reviews should be examined to assess if they are conducted with the same rigor and intensity as AICPA-sponsored reviews.
Decoder-side HEVC quality enhancement with scalable convolutional neural network

The latest High Efficiency Video Coding (HEVC) has been increasingly used to generate video streams over Internet. However, the decoded HEVC video streams may incur severe quality degradation, especially at low bit-rates. Thus, it is necessary to enhance visual quality of HEVC videos at the decoder side. To this end, we propose in this paper a Decoder-side Scalable Convolutional Neural Network (DS-CNN) approach to achieve quality enhancement for HEVC, which does not require any modification of the encoder. In particular, our DS-CNN approach learns a model of Convo-lutional Neural Network (CNN) to reduce distortion of both I and B/P frames in HEVC. It is different from the existing CNN-based quality enhancement approaches, which only handle intra coding distortion, thus not suitable for B/P frames. Furthermore, a scalable structure is included in our DS-CNN, suchthat the computational complexity of our DS-CNN approach is adjustable to the changing computational resources. Finally, the experimental results show the effectiveness of our DS-CNN approach in enhancing quality for both I and B/P frames of HEVC.
Development and conflict in the Balkans: Catch-up and military expenditure

This paper analyses the convergence between countries in relation to the catch-up hypothesis concerning the level of total productivity. The catch-up hypothesis claims that poor countries tend to grow faster than rich countries through the international diffusion of knowledge and technology. We test this hypothesis for the Balkan countries and investigate the effect of military expenditure in the region on productivity growth. The aim is to investigate empirically whether productivity growth has been greater in countries with lower military expenditure, in line with theory. The results obtained show that, overall, improvements in technological change co-exist with deteriorating technical efficiency change and that there is a negative correlation between military expenditure and either total productivity growth and technological change, and a positive, but statistically insignificant, relationship with technical efficiency change. We conclude that economic growth is the key to regional development and that too great a diversion of resources to military commitments can lead to overstretch.
Taxation and Excess Burden: A Life-Cycle Perspective

A lifetime perspective is appropriate in assessing the welfare implications of government tax policies. Although a number of attempts have been made to ex- amine the excess burden of taxation in life-cycle models, these have tended to ignore the role of human capital accumulation and/or the leisure-income choice. In this paper, we do numerical simulations with a model that takes both of these phenomena into account. We find that under reasonable assumptions, the failure to take into account distortions of human capital decisions produces substantial underestimates of the excess burden of income taxation. In addition, allowing for the endogeneity of human capital increases the efficiency of a personal consumption tax relative to that of an equal yield income tax.
Automated genome sequence analysis and annotation

MOTIVATION Large-scale genome projects generate a rapidly increasing number of sequences, most of them biochemically uncharacterized. Research in bioinformatics contributes to the development of methods for the computational characterization of these sequences. However, the installation and application of these methods require experience and are time consuming. RESULTS We present here an automatic system for preliminary functional annotation of protein sequences that has been applied to the analysis of sets of sequences from complete genomes, both to refine overall performance and to make new discoveries comparable to those made by human experts. The GeneQuiz system includes a Web-based browser that allows examination of the evidence leading to an automatic annotation and offers additional information, views of the results, and links to biological databases that complement the automatic analysis. System structure and operating principles concerning the use of multiple sequence databases, underlying sequence analysis tools, lexical analyses of database annotations and decision criteria for functional assignments are detailed. The system makes automatic quality assessments of results based on prior experience with the underlying sequence analysis tools; overall error rates in functional assignment are estimated at 2.5-5% for cases annotated with highest reliability ('clear' cases). Sources of over-interpretation of results are discussed with proposals for improvement. A conservative definition for reporting 'new findings' that takes account of database maturity is presented along with examples of possible kinds of discoveries (new function, family and superfamily) made by the system. System performance in relation to sequence database coverage, database dynamics and database search methods is analysed, demonstrating the inherent advantages of an integrated automatic approach using multiple databases and search methods applied in an objective and repeatable manner. AVAILABILITY The GeneQuiz system is publicly available for analysis of protein sequences through a Web server at http://www.sander. ebi.ac. uk/gqsrv/submit
Real Earnings Management and Long-Term Operating Performance: The Role of Reversals in Discretionary Investment Cuts

ABSTRACT: I examine whether a reversal of an abnormal cut in discretionary investments is associated with the degree to which the cut is reflective of real earnings management (REM) and whether and how it predicts future operating performance. I define a reversal as occurring when a firm cuts discretionary investments to a below-expected level in one period and reverts back to at least the expected level of investment during the next period. Unlike accrual earnings management, REM involves deliberately altering the operations of the firm to influence reported accounting numbers. To the extent that such interventions diverge from optimality, they can expose the firm to real economic costs. I find that a reversal of an abnormal cut in discretionary investments in the year after the cut has taken place is indicative of REM. I further find that, on average, reversing cuts are associated with lower future operating performance, but that such results vary significantly depending on the various incentives to eng.