Miracle-dz/UniFAR-FTUs huggingface dataset:
Low-Cost Three-Dimensional Navigation Solution for RISS/GPS Integration Using Mixture Particle Filter

Recent technological advances in both GPS and low-cost microelectromechanical-system (MEMS)-based inertial sensors have enabled the monitoring of the location of moving platforms for numerous positioning and navigation (POS/NAV) applications. GPS is presently widely used in land vehicles. However, in some environments, the GPS signal may suffer from signal blockage and multipath effects that deteriorate the positioning accuracy. When miniaturized inside any moving platforms, the MEMS-based inertial navigation system (INS) can be integrated with GPS and enhance the performance in denied GPS environments (like in urban canyons). Targeting a low-cost navigation solution for land vehicles, this paper uses a reduced inertial sensor system (RISS) with MEMS-based inertial sensors. In this paper, the RISS consists of one single-axis gyroscope and a two-axis accelerometer used together with the vehicle's odometer, and the whole system is integrated with GPS to obtain a 3-D navigation solution. The traditional technique for this integration problem is Kalman filtering (KF). Due to the inherent errors of MEMS inertial sensors and the relatively high noise levels associated with their measurements, KF has limited capabilities in providing accurate positioning. Particle filtering (PF) was recently suggested as a nonlinear filtering technique to accommodate arbitrary inertial sensor characteristics, motion dynamics, and noise distributions. An enhanced version of PF is utilized in this paper and is called Mixture PF. The performance of the proposed 3-D navigation solution using Mixture PF for RISS/GPS integration is examined by road-test trajectories in a land vehicle. The proposed method is compared with four other solutions: 1) 3-D solution using KF for full INS/GPS integration; 2) 2-D solution using KF for RISS/GPS integration; 3) 2-D solution using Mixture PF for RISS/GPS integration; and 4) 3-D solution using sampling/importance resampling (SIR) PF for RISS/GPS integration. The experimental results show that the proposed solution outperforms all the compared counterparts.
Intestine-specific ablation of mouse atonal homolog 1 (Math1) reveals a role in cellular homeostasis.

BACKGROUND & AIMS Math1 (Atoh1) is a basic helix-loop-helix transcription factor important for intestinal secretory cell differentiation. We hypothesized that Math1 is important in cell fate commitment, and therefore mediates proliferative homeostasis and the adaptive response following intestinal resection in the adult intestine. METHODS We generated mice with an intestine-specific mosaic deletion of Math1 (Math1(Delta intestine)) using the Cre/loxP system. Histologic analysis in adult Math1(Delta intestine) and wild-type littermates at baseline and following small bowel resection or sham surgery was performed. RESULTS We observed loss of Paneth, goblet, and enteroendocrine cells in Math1-null crypts. In addition, aberrant activation of the Math1 promoter occurred in absorptive enterocytes derived from Math1-null crypts, suggesting a change in cell fate. Proliferation was increased but apoptosis unchanged in Math1-mutant crypts compared to adjacent wild-type crypts. Math1(Delta intestine) mice and wild-type littermates displayed similar physiologic adaptive responses to small bowel resection as measured by changes in body weight and ileal wet weight. In contrast, Math1-mutant crypts displayed a blunted adaptive response compared to adjacent wild-type crypts. CONCLUSIONS We show that Math1 is essential for adult intestinal secretory cell production, and in its absence cells destined to a secretory phenotype instead adopt an absorptive phenotype. Subtle abnormalities of proliferation within Math1-null crypts in Math1(Delta intestine) mice were identified, together with a substantial defect in the adaptive response of Math1-null crypts following small bowel resection. Our results suggest that Math1 is critical for both cell fate determination within the intestinal epithelium and for regulation of the response to intestinal resection.
p16 as a prognostic indicator in ovarian/tubal high‐grade serous carcinoma

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Effect of crude extracts of leaves of S mallanthus sonchifolius ( yacon ) on glycemia in diabetic rats

The present study investigated the effect of crude extracts from yacon leaves, obtained by aqueous cold (YC) or hot (YH) extraction, or hydroethanolic extraction (YE), on glycemia of the diabetic (induced by streptozotocine, 50 mg/kg, ip) and nondiabetic rats. The animals were treated orally with the extracts (400 mg/kg) or water for 3, 7, 10, and 14 days. After this period, the animals were anesthetized and blood samples were collected for measurement of plasmatic glucose and creatinine and activity of the enzymes (AST, ALT, ALP). Also were evaluated the consumption of food, water, urine volume, body weight of the animals and LD50 of YE. Treatment with YE for 14 days reduced glycemia in diabetic and nondiabetic animals. No similar reduction was observed in animals treated with YC or YH. Additionally, YE restored the activity of the plasmatic enzymes that were altered, and improved weight gain in the diabetic animals. These results showed that the effectiveness of the yacon extracts is related to the method of preparation and to the time of treatment. The effect of YE on glycemia in diabetic rats is not related to reduction of food intake or to interference of the extract with intestinal absorption of carbohydrates. *Correspondence:
Growth effects of Rhizobium inoculation in some legume plants

Leguminous crops, possessing root nodules, fix and utilize atmospheric nitrogen. They are thus not dependent on industrially fixed nitrogen but add up to 30 kg of nitrogen / hectare to the soil and improve its fertility. Access to mineral nitrogen often limits plant growth, and so symbiotic relationships have evolved between plants and a variety of nitrogen-fixing organisms. These associations are responsible for reducing 120 million tons of atmospheric nitrogen to ammonia each year. In agriculture, independence from nitrogenous fertilizers expands crop production and minimizes pollution of water tables, lakes and rivers. Two kinds of pulses, Vigna mungo and Vigna radiata were taken for this study to find out the impact of artificial inoculation of Rhizobium japonicum with charcoal carrier on the production of grains over the non inoculated one. The results show that in both V. mungo and V. radiata varieties studied, the inoculated plants possessed greater height, greater fresh weight, greater number of roots, nodules, greater number of leaves, shoots, pods, greater length of pods, greater seed weight, over their respective controls. The percentage increase in all these parameters was statistically significant. Hence it is concluded that the commercial inocula of Rhizobium with charcoal used by as in seed inoculation of the pulses namely Vigna mungo (Linn.) Hepper. T-9 variety and Vigna radiata (Linn.) Wilzek S- 8 variety has resulted in significant increases in growth and yield potential over the respective non inoculated control plants.
D-Amino acid scan of gamma-melanocyte-stimulating hormone: importance of Trp(8) on human MC3 receptor selectivity.

In our search for potent and receptor-selective agonists and antagonists, we report here the results of D-amino acid substitution at each position of the short peptide gamma-melanocyte-stimulating hormone (gamma-MSH). The native gamma-MSH shows weak binding at all three receptors (i.e., the human MC3, MC4, and MC5) and a selectivity of 1-2 orders of magnitude at the MC3R over the MC4R and MC5R. Sequential replacement of each residue in the gamma-MSH sequence with the corresponding D-isomer results in analogues which mostly have weaker binding affinity than the native peptide, except for two analogues. For the DTrp(8) analogue, there is an increase in binding affinity by about 1 order of magnitude (IC(50) = 6 nM) at the MC3R compared with that of the natural molecule and an increase in selectivity for the MC3R by 2 orders of magnitude compared with the activity at the MC4R and MC5R. The DPhe(6) analogue is about 10-fold more potent (IC(50) = 8.8 nM) at the MC3R compared with the native peptide but lacks subtype selectivity. Measurement of the intracellular cAMP accumulation in human MC3R, MC4R, and MC5R revealed that the native peptide shows potent activity at the MC3R (EC(50) = 5.9 nM) and is about 50-100-fold selective at this receptor compared with the MC4R and MC5R. The DArg(10) (EC(50) = 35 nM) and DPhe(11) (EC(50) = 11 nM) analogues are selective for the MC3R by 1 and 2 orders of magnitude compared with the MC4R and MC5R, respectively. The DTrp(8) compound (EC(50) = 0.33 nM) shows about 300- and 250-fold increase in selectivity at the MC3R compared with the MC4R and MC5R, respectively. Finally, the DTyr(1) peptide is selective for the MC3R (EC(50) = 12 nM) by 40-200-fold compared with the MC4R and MC5R. In general, the trend is that D-amino acid substitutions of the aromatic residues 1, 6, 8, and 11 and the basic residue Arg(10), but not Arg(7), result in an increase in MC3R selectivity over the MC4R and MC5R and only agonist activity is observed. Thus, the key residues of gamma-MSH identified in this study include the aromatic residues 1, 6, 8, and 11 and the basic residue Arg(10) (but not Arg(7)), as important for MC3 selectivity over the MC4 and MC5 subtypes. Further, the study reveals the extreme importance of DTrp at position 8 in imparting potency and selectivity since this is the most selective analogue for the human MC3R reported thus far.
Scanning laser ophthalmoscope measurement of local fundus reflectance and autofluorescence changes arising from rhodopsin bleaching and regeneration.

PURPOSE We measured the bleaching and regeneration kinetics of rhodopsin in the living human eye with two-wavelength, wide-field scanning laser ophthalmoscopy (SLO), and investigated the effect of rhodopsin bleaching on autofluorescence intensity. METHODS The retina was imaged with an Optos P200C SLO by its reflectance of 532 and 633 nm light, and its autofluorescence excited by 532 nm light, before and after exposure to lights calibrated to bleach rhodopsin substantially. Bleaching was confined to circular retinal regions of 4.8° visual angle located approximately 16° superotemporal and superonasal to fixation. Images were captured as 12-bit tiff files and postprocessed to extract changes in reflectance and autofluorescence. RESULTS At the locus of bleaching transient increases in reflectance of the 532 nm, but not the 633 nm beam were observed readily and quantified. A transient increase in autofluorescence also occurred. The action spectrum, absolute sensitivity, and recovery of the 532 nm reflectance increase were consistent with previous measurements of human rhodopsin's spectral sensitivity, photosensitivity, and regeneration kinetics. The autofluorescence changes closely tracked the changes in rhodopsin density. CONCLUSIONS The bleaching and regeneration kinetics of rhodopsin can be measured locally in the human retina with a widely available SLO. The increased autofluorescence excited by 532 nm light upon bleaching appears primarily due to transient elimination of rhodopsin's screening of autofluorescent fluorochromes in the RPE. The spatially localized measurement with a widely available SLO of rhodopsin, the most abundant protein in the retina, could be a valuable adjunct to retinal health assessment.
Novel solvent-based method for preparation of alginate beads with improved roundness and predictable size

Attempts to determine conditions or processes within alginate gel beads often suffer from inaccuracies due to an improper roundness of the analysed beads. Therefore, a novel solvent-based method for the preparation of alginate beads with improved shape was developed: An aqueous solution of 2% (w/v) alginate in water was injected into a solvent layering consisting of hexane, n-butanol, n-butanol with 1% (w/v) CaCl2 and finally 2% (w/v) CaCl2 in water. Beads of up to 3.5 mm in diameter obtained with this method had a roundness which was ∼5% better than comparable beads prepared by dropping an alginate solution into a CaCl2-hardening bath. This was determined by a software supported quantitative analysis of bead size and shape. Additionally, the novel solvent-based method allows for highly reproducible preparation of alginate beads with exactly predictable sizes. The biggest beads obtained with this method were 9 mm in diameter. Thus, with the solvent-based preparation of alginate beads it is now possible to easily obtain beads of exactly the type needed for a specific analytical purpose.
Non-recurrent laryngeal nerve related to thyroid surgery: a report of 5 cases and literature review.

BACKGROUND Non-recurrent laryngeal nerve, a rare anomaly, passes transversely into larynx with or without its recurrent branches directly arising from the vagus nerve. The paper investigates clinical significance of non-recurrent laryngeal nerve during thyroid surgery. Clinical data from 5 cases of non-recurrent laryngeal nerve and related literature reviews were made to acknowledge its incidence, variant types and matters concerned during thyroid operations. CASE REPORT 821 recurrent laryngeal nerves were anatomized during 2496 thyroid operations, from which 5 were confirmed to hold non-recurrent laryngeal nerves (0.61%). 3 patients were found to have non-recurrent laryngeal nerves during re-operation because of voice horse after the first operation which improved much after re-operation. The other two patients were recognized during the first operation. All 5 cases were not diagnosed preoperatively. CONCLUSIONS Non-recurrent laryngeal nerve, a rare anomaly, is very vulnerable during thyroid surgery. It is helpful to avoid injuring non-recurrent laryngeal nerve that identification of the non-recurrent laryngeal nerve and its types.
Industrial Estate and Export Decision of Manufacturing Firms in Indonesia

Industrial estates may influence a firm’s decision to export through better facilities and agglomeration economies. This paper investigates whether a firm’s export decision in the industrial estate is better than those outside. We then assess how industrial estate characteristics determine a firm’s decision to export.Treatment effect methods are used to compare a firm’s decision to export for those inside and outside of the industrial estate. A probit model is developed to assess how industrial estate characteristics (port distance, port capacity, electricity, water, number of tenants and fiscal incentive) affect a firm’s decision to export. We conduct a qualitative analysis through in-depth interviews with industrial estate top level managers and related institutions.The results show that a firm’s decision to export in the industrial estate was better. At the national level, industrial estate characteristics that affect firm’s export decision are water sources and fiscal incentives. At the regional level, especially in the Greater Jakarta area, almost all of the characteristics affected a firm’s decision to export. Utilities such as electricity and water sources positively affect a firm’s decision to export. Agglomeration economies which is represented by number of tenants and government fiscal policy is effective in increasing a firm’s decision to export.
The Limited Capacity of Humans to Identify the Components of Taste Mixtures and Taste – Odour Mixtures

The capacity of humans to identify the components of taste mixtures and odour – taste mixtures was investigated in two experiments. Subjects were trained to identify the components presented alone and to use a ‘yes/no’ procedure to identify them in mixtures. All stimuli were presented with a retronasal (by mouth) technique. A maximum of three tastants were identified in both types of mixtures, only one tastant was identified in five-component taste mixtures, and no component was identified in four-component odour – taste mixtures. Importantly, in no instance was the olfactory stimulus identified in any mixture with tastes, including binary mixtures. Loss of identity of the odorant in binary and ternary mixtures may have been due to suppression as a consequence of temporal processing, or to the absence of an association between the odorant and tastants that had established an identifiable percept. In contrast, poor identification of the components of the quaternary odour – taste mixture and quinternary taste mixture is attributed to the limited capacity of working memory. Overall, the poorer ability to identify components in odour–taste mixtures than in taste mixtures indicates that interactions occurred between the two senses, challenging the proposal that odours and tastes are processed independently when present in complex chemosensory stimuli.
Gender bias in the selection of estate surveyors and valuers in Lagos Property Market

The Estate Surveyors and Valuers (ESV) as a real property service provider normally receive instruction/ brief from the clients mostly from property owners for assignments that span through their range of services. In the process, it has been observed that there is gender bias in clients’ selection of whom to give the assignments relating to their property assets. This study identified the proportion of male and female ESV/agents practicing in the study area, measured the selection criterion their clients were biased with, and determined the causes of bias in order to correct gender imbalances in real property market transactions The study methodology adopted survey design in which the target population was the property owners whose properties were being managed by the ESV/agents within Ikeja Local Government Areas (LGAs) of Lagos State, Nigeria. The Year 2014 edition of the Directory of members and registered firms of ESV was used to pick the 64 practicing firms within the LGAs. Two properties owners randomly sampled from each of these ESV firms’ management files. Closeended questionnaire was employed to collect relevant data from the 128 property owners. Data collected were analyzed using weighted mean scores and discriminant function analysis to resolve the study objectives. The findings showed there was higher proportion of male ESV than female, in both staff strength and clients choice. There were bias orchestrated by personal relationship, knowledge and experience. Bias was found to be a function of environmental and natural human tendencies and notion of lack of competence of female than male ESV. The study recommended that female ESV should brace up to compete by exhibiting high level of managerial qualities as good/first impression sustained delivery and performance/success. Keywords: Estate Surveyors and Valuers, Gender Bias, Lagos, Property Market
The intention–behaviour gap in technology usage: the moderating role of attitude strength

Extant theories of information technology (IT) usage present users' behavioural intention as the primary predictor of their IT usage behaviour. However, empirical evidence reveals only a low-to-medium effect size for this association. We call this inconsistency the ‘intention–behaviour gap’, and argue that a clearer understanding of this gap requires a deeper theoretical examination of the conditions under which intentions may or may not influence behaviour. Drawing on recent attitude theoretic research in social psychology, we distinguish between two types of attitudes – strong versus weak – and suggest that the intention–behaviour association may hold for users with strong attitudes but is likely to be weaker for those with weak attitudes. Using the elaboration-likelihood model, we propose two dimensions of attitude strength relevant to the IT usage context – personal relevance and related expertise – and theorise them to moderate the intention–behaviour association in a positive manner. Results from a longitudinal field survey of document management system usage among governmental employees at L'viv City Hall, Ukraine support our theoretical hypotheses. Theoretical and practical implications of our findings are discussed.
Suicidal ideation in family carers of people with dementia

Objective: Two small studies have suggested that family carers of people with dementia may be a high-risk group for suicide. The objective of this study was to further explore the rate of suicidal ideation in a large sample of carers and identify psychosocial risk and protective factors. Method: A cross-sectional survey was conducted with 566 family carers. The survey included measures of suicidality, self-efficacy, physical health, depression, anxiety, hopelessness, optimism, burden, coping strategies, and social support. Results: Sixteen percent of carers had contemplated suicide more than once in the previous year. There were univariate differences between suicidal and non-suicidal carers on self-efficacy, social support, coping, burden, depression, anxiety, hopelessness, optimism, reasons for living, and symptoms of dementia, as well as age and income management. In a multivariate model, age, depression, and reasons for living predicted suicidal ideation. In tests for mediation, satisfaction with social support and dysfunctional coping had indirect effects on suicidal ideation via depression. Conclusion: Family carers of people with dementia have high rates of suicidal ideation, with depression a risk factor and increasing age and reasons for living as protective factors. Depression and reasons for living should be targeted in interventions to reduce suicide risk in dementia carers.