Miracle-dz/UniFAR-FTUs huggingface dataset:
Lysophosphatidic Acid Stimulates Prostaglandin E2 Production in Cultured Stromal Endometrial Cells Through LPA1 Receptor

Lysophosphatidic acid (LPA) has been shown to be a potent modulator of prostaglandin (PG) secretion during the luteal phase of the estrous cycle in the bovine endometrium in vivo. The aims of the present study were to determine the cell types of the bovine endometrium (epithelial or stromal cells) responsible for the secretion of PGs in response to LPA, the cellular, receptor, intracellular, and enzymatic mechanisms of LPA action. Cultured bovine epithelial and stromal cells were exposed to LPA (10−5–10−9 M), tumor necrosis factor α (TNFα; 10 ng/mL) or oxytocin (OT; 10−7 M) for 24 h. LPA treatment resulted in a dose-dependent increase of PGE2 production in stromal cells, but not in epithelial cells. LPA did not influence PGF2α production in stromal or epithelial cells. To examine which type of LPA G-protein–coupled receptor (LP-GPCR; LPA1, LPA2, or LPA3) is responsible for LPA action, stromal cells were preincubated with three selected blockers of LPA receptors: NAEPA, DGPP, and Ki16425 for 0.5 h, and then stimulated with LPA. Only Ki16425 inhibited the stimulatory effect of LPA on PGE2 production and cell proliferation in the stromal cells. LPA-induced intracellular calcium ion mobilization was also inhibited only by Ki16425. Finally, we examined whether LPA-induced PGE2 synthesis in stromal cells is via the influence on mRNA expression for the enzymes responsible for PGE2 synthesis—PGE 2 synthase (PGES) and PG-endoperoxide synthase 2 (PTGS2). We demonstrated that the stimulatory effect of LPA on PGE2 production in stromal cells is via the stimulation of PTGS2 and PGES mRNA expression in the cells. The overall results indicate that LPA stimulates PGE2 production, cell viability, and intracellular calcium ion mobilization in cultured stromal endometrial cells via Ki16425-sensitive LPA1 receptors. Moreover, LPA exerts a stimulatory effect on PGE2 production in stromal cells via the induction of PTGS2 and PGES mRNA expression.
Personal Costs and Benefits of Employee Intrapreneurship: Disentangling the Employee Intrapreneurship, Well-Being, and Job Performance Relationship

Ample studies have confirmed the benefits of intrapreneurship (i.e., employee behaviors that contribute to new venture creation and strategic renewal activities) for firm performance, but research on the personal costs and benefits of engaging in intrapreneurial activities for employees is lacking. Building on job demands–resources and reinforcement sensitivity theories, we examined how employees’ reinforcement sensitivity qualified the relationship among their intrapreneurial behavior, subjective well-being, and other-rated job performance. Using a sample of 241 employee dyads, the results of moderated mediation analyses confirmed that employee intrapreneurship related positively to work engagement for employees high (vs. low) in sensitivity to rewards (behavioral approach system), which subsequently related positively to innovativeness and in-role performance and negatively to work avoidance. In contrast, employee intrapreneurship related positively to exhaustion for employees high (vs. low) in sensitivity to punishments (behavioral inhibition system), which subsequently related positively to work avoidance and negatively to in-role performance (but not to innovativeness). Theoretical and practical implications are discussed.
Bronchial colonization and postoperative respiratory infections in patients undergoing lung cancer surgery.

STUDY OBJECTIVES To evaluate the risk factors associated with postoperative respiratory infection in patients undergoing lung cancer surgery, with special emphasis on the perioperative pattern of airway colonization. DESIGN Prospective cohort study. SETTING Department of Pneumology and Thoracic Surgery of a tertiary hospital. PATIENTS Seventy-eight consecutive patients undergoing lung cancer surgery were evaluated. Patients were followed up until hospital discharge or death. INTERVENTIONS Fiberoptic bronchoscopies with bilateral protected specimen brush or bronchial aspirates were performed during anesthesia prior to the initiation of the surgical procedure. RESULTS Sixty-five patients (83%) had perioperative bronchial colonization by either potentially pathogenic microorganisms (PPMs) [28 patients, 36%] or non-potentially pathogenic microorganisms (56 patients, 72%). The 24 patients (31%) with a postoperative respiratory infection (pneumonia, purulent tracheobronchitis, or pleural empyema) had significantly higher perioperative bronchial colonization by PPMs (15 patients [63%] vs 13 patients [24%], p = 0.003) and a higher bacterial index (mean +/- SD, 3.6 +/- 3.3 vs 0.9 +/- 1.4; p = 0.003), compared to patients without infection. The agreement between pathogens found in perioperative evaluation and during postoperative infection was total in 5 patients (21%), partial in 5 patients (21%), and no concordance in 14 patients (58%). In the multivariate analysis, the presence of perioperative airway colonization by a PPM (odds ratio [OR], 6.9; p = 0.001) and a higher postoperative pain score (OR, 4.1; p = 0.014) were independent predictors of postoperative respiratory infection. CONCLUSION Adequate control of postoperative pain, as well as the conditions that potentially cause airway colonization by PPMs, could be beneficial in preventing postoperative respiratory infections after lung cancer surgery.
Test-Retest Reliability of a Novel Isokinetic Squat Device With Strength-Trained Athletes

Abstract Bridgeman, LA, McGuigan, MR, Gill, ND, and Dulson, DK. Test-retest reliability of a novel isokinetic squat device with strength-trained athletes. J Strength Cond Res 30(11): 3261–3265, 2016—The aim of this study was to investigate the test-retest reliability of a novel multijoint isokinetic squat device. The subjects in this study were 10 strength-trained athletes. Each subject completed 3 maximal testing sessions to assess peak concentric and eccentric force (N) over a 3-week period using the Exerbotics squat device. Mean differences between eccentric and concentric force across the trials were calculated. Intraclass correlation coefficients (ICCs) and coefficients of variation (CVs) for the variables of interest were calculated using an excel reliability spreadsheet. Between trials 1 and 2 an 11.0 and 2.3% increase in mean concentric and eccentric forces, respectively, was reported. Between trials 2 and 3 a 1.35% increase in the mean concentric force production and a 1.4% increase in eccentric force production was reported. The mean concentric peak force CV and ICC across the 3 trials was 10% (7.6–15.4) and 0.95 (0.87–0.98) respectively. However, the mean eccentric peak force CV and ICC across the trials was 7.2% (5.5–11.1) and 0.90 (0.76–0.97), respectively. Based on these findings it is suggested that the Exerbotics squat device shows good test-retest reliability. Therefore practitioners and investigators may consider its use to monitor changes in concentric and eccentric peak force.
Diagnosis and treatment of cervical cancer during pregnancy.

CONTEXT AND OBJECTIVE One third of all cervical carcinomas occur during the reproductive period. Cervical carcinoma is the second greatest cause of death due to cancer during this phase. The estimated frequency of cervical cancer during pregnancy is one case for every 1,000 to 5,000 pregnancies. The aim here was to provide information about the difficulties in diagnosing and managing cervical neoplasia during pregnancy. MATERIALS A systematic review of the literature was undertaken through the PubMed, Cochrane, Excerpta Medica (Embase), Literatura Latino Americana e do Caribe em Ciências da Saúde (Lilacs) and Scientific Electronic Library Online (SciELO) databases, using the following words: pregnancy, cervical cancer, diagnosis and management. RESULTS There was a consensus in the literature regarding diagnosis of cervical carcinoma and management of preneoplastic lesions during pregnancy. However, for management of invasive carcinoma, there was great divergence regarding the gestational age taken as the limit for observation rather than immediate treatment. CONCLUSION All patients with cytological abnormalities should undergo colposcopy, which will indicate and guide biopsy. Conization is reserved for patients with suspected invasion. High-grade lesions should be monitored during pregnancy and reevaluated after delivery. In cases of invasive carcinoma detected up to the 12th week of pregnancy, patient treatment is prioritized. Regarding diagnoses made during the second trimester, fetal pulmonary maturity can be awaited, and the use of chemotherapy to stabilize the disease until the time of delivery appears to be viable.
Total serum testosterone and gonadotropins in workers exposed to dioxin.

Human reproductive endocrine data may be an important source of epidemiologic information in regard to the toxic potential of 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin). The association of serum dioxin with total serum testosterone, luteinizing hormone, and follicle-stimulating hormone was examined in 248 chemical production workers from New Jersey and Missouri plants and 231 nonexposed neighborhood referents who participated in a medical evaluation in 1987. In linear regression analyses, current serum dioxin was positively and significantly related to luteinizing hormone and follicle-stimulating hormone and inversely related to total testosterone after adjustment for potential confounders (p < 0.05). These trends were also apparent in logistic regression analyses, in which the authors examined the odds ratios of high luteinizing hormone (> 28 IU/liter), high follicle-stimulating hormone (> 31 IU/liter), and low testosterone (< 10.4 nmol/liter) by serum dioxin quartiles. There was a greater prevalence of high luteinizing hormone among workers in the second (odds ratio (OR) = 1.9, 95% confidence interval (CI) 0.7-5.5), third (OR = 2.5, 95% CI 0.9-7.3), and fourth (OR = 1.9, 95% CI 0.7-5.0) quartiles of serum dioxin compared with referents. For follicle-stimulating hormone, the authors observed a greater prevalence of high follicle-stimulating hormone among workers in the fourth quartile (OR = 2.0, 95% CI 0.7-5.6) compared with referents. Similarly, the prevalence of low testosterone was two to four times greater among workers in the second (OR = 3.9, 95% CI 1.3-11.3), third (OR = 2.7, 95% CI 0.9-8.2), and fourth quartiles (OR = 2.1, 95% CI 0.8-5.8) than among referents. The trends observed in these data offer human evidence of alterations in male reproductive hormone levels associated with dioxin exposure. The results support the animal literature in which dioxin-related effects have been observed on the hypothalamic-pituitary-Leydig-cell axis and on testosterone synthesis.
Population-Based Study on the Practice of Breastfeeding in Children Born with Cleft Lip and Palate

Objective To investigate the practice of breastfeeding and related difficulties in children born in Porto Alegre, Brazil, with cleft lip, cleft palate, and cleft lip with cleft palate. Design Cohort, observational, and population-based study. Population and Sample Mothers of all children born in 2001 and 2002 with cleft lip and palate in the city of Porto Alegre, Brazil (n = 31), were interviewed in their homes. From the information collected, the frequencies of breastfeeding and exclusive breastfeeding in the first year of life were estimated and the median duration was computed according to the type of cleft. A descriptive analysis was used to study the difficulties. Main Indicators Initiation rate, pattern, duration, and difficulties of breastfeeding and exclusive breastfeeding. Results The initiation rate of breastfeeding was 100% and its median duration was 42.5 days. Exclusive breastfeeding was initiated by 67.7% of the sample and maintained for 15 days (median). The breastfeeding duration was significantly higher in the presence of cleft lip, being equal or even superior to (in the case of exclusive breastfeeding) the median of Porto Alegre's general population. The most frequently mentioned difficulties were weak suction, difficulty attaching to the breast, and breast milk escaping through the nostrils. Conclusions In spite of the diverse difficulties reported and the lack of professional support after discharge from the maternity wards, the initiation rate and the duration of breastfeeding of children with cleft lip and palate found in this study reinforce the theory that this malformation, especially cleft lip, is compatible with successful breastfeeding.
Systematic evolution of temperature-dependent resistivity in La2-xSrxCuO4.

The in-plane resistivity (ρ ab ) of La 2-x Sr x CuO 4 has been studied over a wide temperature (4-1000 K) and composition range (0 0.2), ρ ab follows a novel power-law dependence, ρ∞T 1.5 , over the entire temperature range up to 1000 K
Determination of farm-level risk factors for abnormalities observed during post-mortem meat inspection of lambs: a feasibility study

To investigate the feasibility of using information about the health and management of lambs on farms to predict the risk of gross abnormalities at post-mortem meat inspection, 6732 lambs from 30 different farms in Great Britain were followed through to slaughter in 1995/6. The farm-level data were collected during farm visits at the beginning of the study. Routine meat inspection findings for the lambs were obtained from the 10 participating abattoirs. The most common abnormalities found during post-mortem inspection were pneumonia/pleurisy (53% of cohorts), lungworm (40%), abscesses (30%), liver fluke (27%) and nephritis/nephrosis (27%). The farm-level risk factors associated with abnormalities at slaughter varied with the type of lesion. The most significant risk factor was the age of the lambs at slaughter. Lambs slaughtered at an older age were more likely to have an abnormality, especially pneumonia, abscesses and liver fluke. After age, environmental factors appeared to be better predictors of those cohorts that would have lesions at slaughter than health and disease control variables. However, a much larger study would be required to identify a set of farm-level factors that adequately discriminated between lambs with high and low risks of lesion at slaughter. At the end of the study, the farmers were informed of the meat inspection findings for their lambs and a third indicated that they would improve their animal husbandry as a result of the information.
A Patient with Synchronous Follicular ( Hurthle Cell ) , Papillary , and Medullary Thyroid Carcinomas : A Case Report with Literature Review on Possible Incidence and Pathogenesis

This case report is the fourth case documented of a patient with synchronous Follicular, Papillary, and Medullary Thyroid Carcinoma. There have been several case series in the last two decades that include either concurrent papillary-medullary or follicular-medullary thyroid carcinoma, but only three cases documented for all three of these types of thyroid carcinomas occurring in the same patient. There has been conflicting research on whether the pathogenesis of such synchronicity is coincidental or molecular/genetically linked. Advances in molecular/genetic detection in the last five years has elucidated new evidence that synchronous occurrence of MTC, PTC, and FTC may be coincidental.
Deep Learning for Optical Vehicular Communication

In this paper, we consider the current status and technical issues involved in the use of optical camera communication (OCC)/visible light communication (VLC) technologies in vehicular communication systems. Hybrid spatial phase-shift keying was introduced in IEEE 802.15. 7-2018 as the standard hybrid modulation scheme for vehicular OCC/VLC systems. We herein propose a functional communication system architecture for vehicular systems based on this hybrid waveform, and we also present state-of-the-art research work on an artificial intelligence (AI)-based vehicular OCC system. Every AI module within the proposed system architecture is discussed in detail. Finally, our experimental procedures and results are analyzed to evaluate the performance of the proposed system over a complex channel model in a vehicular environment. We effectively employed the popular You Only Look Once version 2 object detection algorithm for real-time region-of-interest tracking in city driving (at a vehicular velocity of around 30 km/h and highway night driving (at a vehicular velocity of > 60 km/h) scenarios. Moreover, our novel neural-network-based decoder and AI-based error correction proved effective in improving the data decoding accuracy, resulting in a best-case reduction of 2.2 and 9.0 dB, respectively, in the signal-to-noise ratio needed to achieve the desired bit error rate of 10−4 in a vehicular OCC/VLC system.
Facultative Mate Choice Drives Adaptive Hybridization

Mating with another species (hybridization) is often maladaptive. Consequently, females typically avoid heterospecifics as mates. Contrary to these expectations, female spadefoot toads were more likely to choose heterospecific males when exposed to environmental conditions that favor hybridization. Indeed, those females with phenotypic characteristics for which hybridization is most favorable were most likely to switch from choosing conspecifics to heterospecifics. Moreover, environmentally dependent mate choice has evolved only in populations and species that risk engaging in, and can potentially benefit from, hybridization. Thus, when the benefits of mate choice vary, females may radically alter their mate selection in response to their own phenotype and their environment, even to the point of choosing males of other species.
Dissonance and Importance: Attitude Change Effects of Personal Relevance and Race of the Beneficiary of a Counterattitudinal Advocacy

The authors asked or instructed White college students to write an essay advocating a large tuition hike to increase scholarships for either students in general or Black students (yielding low or high racial symbolism, respectively) that would take effect in the near or far future (yielding high or low personal relevance, respectively). Especially when high-choice participants wrote highly compliant (i.e., unqualified) essays, attitude change was greater when the advocacy had either high (vs. low) personal relevance or high (vs. low) racial symbolism. Yet there was no attitude change when both symbolism and relevance were high. They may increase dissonance by making the dissonant elements more important and numerous. The coupling of relevance and symbolism, however, may link the attitude so strongly to personal values and self-concept that attitude change becomes untenable as a mode of dissonance reduction.
Malignant catatonia secondary to sporadic encephalitis lethargica

Catatonia is a neuropsychiatric syndrome characterised by a combination of psychosocial withdrawal and various movement disorders. Kahlbahm first described this syndrome in 1868 when he noted this condition of “profound mental anguish”. In 1893, Kraeplin limited catatonia to a subtype of dementia praecox, later redefined by Bleuler in 1906 as catatonic schizophrenia. Since then, it has become increasingly apparent that the catatonic syndrome can be seen not just in schizophrenia, but in affective disorders as well as secondary to various underlying medical conditions, leading the DSM-IV to broaden its categorisation of catatonia to include these other entities. In the early 1900s, a condition known variously as epidemic encephalitis, encephalitis lethargica, or Von Economo's disease was described, affecting more than 65 000 patients from 1919 to 1929.1Case descriptions reported during this time bear striking similarities to our modern definitions of catatonia. Throughout recent years, isolated cases of encephalitis lethargica have been reported.2 3 We present a patient with features of sporadic encephalitis lethargica and discuss management of this entity in the context of catatonia. The patient was a 22 year old previously psychologically and neurologically healthy woman who was transferred to the Barrow Neurological Institute after a 4 week stay in hospital for progressive immobility, mutism, posturing, and tremor. Initial evaluation had shown a CSF lymphocytosis, increased …
French future: Exploring the future ratification hypothesis

The paper proposes a unified account of the systematic polysemy of French future (FUT) that does not uniquely rely on Aktionsart. It explains the predominant preference for the temporal interpretation of FUT, appealing to the ‘future ratification hypothesis’. This is a felicity condition that can be satisfied to different degrees and among competing interpretations the one that satisfies it to the highest degree is preferred. The paper also shows that FUT does not convey uncertainty at utterance time (tu), and can be used when the attitude holder knows at tu that the embedded proposition is true.
Barriers and perceptions regarding different contraceptives and family planning practices amongst men and women of reproductive age in rural Pakistan: A qualitative study

Objectives: To understand the perceptions and barriers towards different contraceptives and to gauge knowledge and attitudes regarding family planning practices amongst men and women in rural Pakistan. Materials and Methods: A qualitative study was conducted using content analysis based on data from eight focus group discussions with men and women of reproductive age (15-49 years). Men and women were grouped separately for the focus group discussions. Results: Sufficient knowledge of both traditional and modern contraceptives exists amongst all groups; however, their usage was low. Furthermore, traditional method usage was high amongst user ; nevertheless adopting a modern method without any contrivance e.g (IUD) was preferred. In addition, personal, social factors such as limited mobility and side effects were seen as barriers to contraceptive use by majority of women whereas most male respondents perceived money and religio-cultural factors as barriers. In addition, most participants believed that size would bring more finances and a prosperous future compared to the health and child rearing benefits of a smaller family. Generally, any cost-effective, easily accessible, and easily administered modern method was preferred by the majority; however, males exclusively favored methods that would not impede their climax. The quality of services offered by private clinics was found satisfactory; although perceived very expensive by majority of the male and female participants as compared to the public sector which was termed unsatisfactory. According to the majority of the men, affordability and willingness to pay took precedence over quality services. On the contrary, women’s desire of local integrated services and satisfaction of the treatment took precedence over economy especially for contraception and to reduce stigma. Conclusions: Efforts aimed at promoting modern contraceptive use in rural Pakistan must address issues of affordability, accessibility, quality of care, and ease of use. However, the research clearly suggests that solely focusing on supply-side issues will be of limited success. Socio-cultural beliefs regarding the benefits of large family size, as well as common perceptions regarding side effects and the impact of certain contraceptive methods on the quality of one’s sexual experiences must be explicitly addressed in order to achieve higher family planning uptake in rural communities.