Miracle-dz/UniFAR-FTUs huggingface dataset:
Distributed Control of Power System Oscillations under Communication and Actuation Constraints

A distributed Model Predictive Control design is presented for inter-area oscillation damping in power systems under two critical cyber-physical constraints namely, communication constraints that lead to sparsification of the underlying communication network, and actuation constraints on excitation controllers. Currently damping controllers are usually executed over fixed communication topologies that are agnostic of the magnitude and location of the incoming disturbance. In contrast, the communication topology for our controller is selected in real-time after a disturbance event, based on event-specific correlations of the generator states with the dominant oscillation modes. The design is validated using a 140-bus power system model.
Relative potency and effectiveness of flunitrazepam, ethanol, and beta-CCE for disrupting the acquisition and retention of response sequences in rats

Despite the knowledge that gamma-aminobutyric acidA modulators can affect learning and memory, their capacity for disrupting each of these complex processes is rarely compared, and often mistakenly assumed to occur with identical potency. For these reasons, the effects of flunitrazepam (0.056–3.2 mg/kg), ethanol (0.25–1.5 g/kg), and ethyl-&bgr;-carboline-3-carboxylate (&bgr;-CCE; 1–17.8 mg/kg) were compared in groups of rats responding under baselines that assessed learning and memory separately. The first baseline was a multiple schedule of repeated acquisition and performance of tandem response sequences, whereas the second baseline was a retention or memory procedure where a tandem response sequence was acquired and then retested after a 30-min delay. Under both procedures, responding was maintained under a second-order fixed-ratio-2 schedule of food reinforcement, and incorrect responding (errors) produced a 5-s timeout. With regard to the effects of the three drugs on sequence acquisition (learning), all three drugs dose dependently decreased the overall response rate and increased the percentage of errors. Both flunitrazepam and &bgr;-CCE affected accuracy more potently than response rate, whereas ethanol was equipotent in affecting these two dependent measures. With regard to the effects of these drugs on sequence retention (memory), both flunitrazepam and ethanol dose dependently decreased retention at doses that had little or no effect on sequence acquisition under the multiple schedule, whereas &bgr;-CCE decreased retention and sequence acquisition similarly at the doses tested. Together, these data show that drugs with differing capacities for altering the function of gamma-aminobutyric acidA receptors differ in their capacity for disrupting the acquisition and retention of response sequences and that positive modulation of this receptor complex may be more predictive of disruptions in memory than disruptions in learning.
NCX-1000, a NO-releasing derivative of ursodeoxycholic acid, selectively delivers NO to the liver and protects against development of portal hypertension

Portal hypertension resulting from increased intrahepatic resistance is a common complication of chronic liver diseases and a leading cause of death in patients with liver cirrhosis, a scarring process of the liver that includes components of both increased fibrogenesis and wound contraction. A reduced production of nitric oxide (NO) resulting from an impaired enzymatic function of endothelial NO synthase and an increased contraction of hepatic stellate cells (HSCs) have been demonstrated to contribute to high intrahepatic resistance in the cirrhotic liver. 2-(Acetyloxy) benzoic acid 3-(nitrooxymethyl) phenyl ester (NCX-1000) is a chemical entity obtained by adding an NO-releasing moiety to ursodeoxycholic acid (UDCA), a compound that is selectively metabolized by hepatocytes. In this study we have examined the effect of NCX-1000 and UDCA on liver fibrosis and portal hypertension induced by i.p. injection of carbon tetrachloride in rats. Our results demonstrated that although both treatments reduced liver collagen deposition, NCX-1000, but not UDCA, prevented ascite formation and reduced intrahepatic resistance in carbon tetrachloride-treated rats as measured by assessing portal perfusion pressure. In contrast to UDCA, NCX-1000 inhibited HSC contraction and exerted a relaxing effect similar to the NO donor S-nitroso-N-acetylpenicillamine. HSCs were able to metabolize NCX-1000 and release nitrite/nitrate in cell supernatants. In aggregate these data indicate that NCX-1000, releasing NO into the liver microcirculation, may provide a novel therapy for the treatment of patients with portal hypertension.
Maternal blood superoxide dismutase in Down syndrome

Hackshaw AK, Wald NJ, Haddow JE. 1996. Down's syndrome screening with nuchal translucency. Lancet 348: 1740. Hook EB, Cross PK, Schreinemachers DM. 1983. Chromosomal abnormality rates at amniocentesis and in live-born infants. J Am Med Assoc 249: 2034±2038. Hook EB, Topol BB, Cross PK. 1989. The natural history of cytogenetically abnormal fetuses detected at midtrimester amniocentesis which are not terminated electively: new data and estimates of the excess and relative risk of later fetal death associated with 47, +21 and some other abnormal karyotypes. Am J Hum Genet 45: 855±861. Morris JK, Wald NJ, Watt HC. 1999. Fetal loss in Down syndrome pregnancies. Prenat Diagn 19: 142±145. Sherod C, Sebire NJ, Soares W, Snijders RJM, Nicolaides KH. 1997. Prenatal diagnosis of trisomy 18 at the 10±14 week ultrasound scan. Ultrasound Obstet Gynecol 10: 387±390. Tul N, Spencer K, Noble P, Chan C, Nicolaides K. 1999. Screening for trisomy 18 by fetal nuchal translucency and maternal serum free b-hCG and PAPP-A at 10±14 weeks of gestation. Prenat Diagn 19: 1035±1042. Wald NJ, Hackshaw AK, Watt H. 1999. Nuchal translucency and trisomy 18. Prenat Diagn 19: 995±996.
Light habitats and the role of polarized iridescence in the sensory ecology of neotropical nymphalid butterflies (Lepidoptera: Nymphalidae)

SUMMARY The exploitation of polarized light may increase perceived visual contrast independent of spectrum and intensity and thus have adaptive value in forest habitats, where illumination varies greatly in brightness and spectral properties. Here we investigate the extent to which Costa Rican butterflies of the family Nymphalidae exhibit polarized wing reflectance and evaluate the types of habitats in which the trait is commonly found. We also examine the degree of polarized reflectance of wing patterns in representative species belonging to the nymphalid subfamilies Charaxinae, Heliconiinae, Morphinae and Nymphalinae. Polarized reflectance was evaluated using museum specimens illuminated with a light source that simulated the spectrum of ambient sunlight and viewed through a polarized filter. Of the 144 species examined, 75 species exhibited polarized reflectance patterns. These species were significantly more likely to occupy forest habitats than open habitats. A concentrated changes test performed on a phylogeny of the Nymphalidae, with the Papilionidae as an outgroup, provides further support for the correlated evolution of polarized iridescence and life in a forest light environment. These results are consistent with the hypothesis that the production and detection of polarized light may have adaptive communicative value in those species inhabiting forest habitats with complex light conditions. The potential utility of polarized iridescence and iridescent wing coloration within differing ambient spectral environments is discussed to provide a basis for future investigation of the polarized light ecology of butterflies.
Application of satellite image time series and texture information in land cover characterization and burned area detection

Land cover is critical information to various land management and scientific applications, including biogeochemical and climate modeling. In addition, fire is an essential factor in shaping of vegetation structures, as well as for the functioning of savanna ecosystems. Remote sensing has long been an important and effective means of mapping and monitoring land cover and burned area over large areas in a consistent and robust way. Owing to the free and open Landsat archive and the increasing availability of high spatial resolution imagery, seasonal features from the temporal domain and the use of texture features from the spatial domain create new opportunities for land cover characterization and burned area detection. This thesis examined the application of satellite image time series and texture information in land cover characterization and burned area detection. First, the utility of seasonal features derived from Landsat time series (LTS) in improving accuracies of land cover classification and attribute prediction in a savanna area in southern Burkina Faso was studied. Then, the temporal profiles from LTS were explored for mapping burned areas over a 16 year period, and MODIS burned area product was used for comparison. Finally, the application of texture features derived from high spatial resolution data in land cover classification and attribute predictions was investigated in a savanna area of Burkina Faso and an urban fringe area in Beijing. According to the results, firstly, seasonal features from LTS based on all available imagery during one year as input led to a significant increase in land cover classification accuracy in comparison to the dry and wet season single date imagery. The harmonic model used for time series modeling provided a robust method for extracting seasonal features, and the influence of burned pixels on seasonal features could be considered simultaneously. Secondly, the annual burned area mapping based on a harmonic model and breakpoint identification with LTS was capable of detecting small and patchy burn scars with higher accuracy than MODIS burned area product. The approach demonstrated the potential of LTS for improving burned area detection in savannas, and was robust against data gaps caused by clouds and Landsat 7 missing lines. Thirdly, predictive models of tree crown cover (CC) using RapidEye and LTS imagery achieved similar accuracy, indicating the importance of texture and seasonal features from RapidEye and LTS imagery, respectively. Predictions of aboveground carbon and tree species richness, which were strongly correlated with CC, were promising using RapidEye and LTS imagery. Finally, the optimized window size texture classification improved classification accuracy in comparison to the classifications with single window size texture features and multiple window size texture features in an urban fringe area in Beijing, indicating the importance of multiscale texture information.
Impact of Livestock Grazing on Abundance of Miridae and Reduviidae (Hemiptera) in Crested Wheatgrass Pastures

Abstract Miridae of the genera Labops and Irbisia, collectively referred to as “black grass bugs,” can cause significant damage to wheatgrasses (Poaceae) of several genera on western North American rangeland. Another mirid in the same area, Capsus cinctus (Kolenati), causes damage to bluegrass (Poa spp.). Previous studies suggest that grazing management may reduce mirid populations on rangeland by eliminating preferred oviposition sites and reducing accumulations of litter that provide diurnal refuges for nymphs. We tested the hypothesis that grazing reduces mirid populations, along with those of Reduviidae, during a controlled grazing experiment. Densities of mirids and reduviids declined with increasing intensity of grazing, even though grazing occurred after the peak of mirid abundance each year. This suggests that declines in hemipteran densities resulted from grazing that occurred during previous years, perhaps because the most heavily grazed plots had the least plant litter. The results further confirm that grazing has the potential to control black grass bug populations, although the benefits could be potentially offset by negative impacts on beneficial insects such as reduviids.
Description and genetic analysis of three sets of monozygotic twins resulting from transfers of single embryos to recipient mares.

CASE DESCRIPTION 3 sets of monozygotic twins resulting from transfers of single embryos to recipient mares were examined. CLINICAL FINDINGS In all 3 recipient mares with twin pregnancies, only 1 embryonic vesicle was detected before day 25 of gestation. In 1 recipient mare, 2 apparent adjacent vesicles, each containing an embryo with a heartbeat, were visualized on ultrasonographic examination on day 37 of gestation. The other 2 recipient mares underwent ultrasonographic examination on day 30 of gestation, at which time only 1 vesicle and embryo was identified. In these latter 2 recipient mares, however, a thorough ultrasonographic examination for a second conceptus on day 30 had not been performed, as only 1 embryo had been transferred and visualized on early ultrasonographic examination. TREATMENT AND OUTCOME All twin pregnancies resulted in death of both fetuses. Genetic analysis confirmed that each set of monozygotic twins originated from the transferred embryo. CLINICAL RELEVANCE Monozygotic twin pregnancy may occur after embryo transfer; thus recipient mares should be examined thoroughly for multiple conceptuses, especially between 25 and 30 days of gestation. At this time, the allantoides of monozygotic twins should be visible ultrasonographically and effective management may still be possible.
Patterns of activity and use of time in rural Bangladesh: class, gender, and seasonal variations.

Tarapur is a village in the district of Rajshahi, Bangladesh, covering an area of 821.05 acres. 342 households with a total population of 1981 were identified in the village by the 1985 census. The author investigated the use of time during 1984 and 1985 in busy, intermediate, and slack seasons among the village population to examine the variation in time use by gender and social class. Activity patterns were found to vary from one season to another, and also across social classes. The study highlights the need to refine some of the conceptual and methodological issues in the collection of data on women and work. The study also presents useful data on home-based production and market-oriented work. It could be useful to adopt an anthropological approach in order to understand the allocation of time by men and women from the perspective of household production and the local economy and culture. Study findings focus upon the following policy issues: the need for a better understanding and recognition of the significant role of women in field agriculture and postharvest processing, creation of further nontraditional employment and business opportunities for poor women in rural areas, and consciousness-raising and the challenge of cultural barriers affecting women. Rural women, especially those in need of employment and involved in market-oriented production, should be the target of mainstream development activities in future planning.
GJB2 and hearing impairment: promoter defects do not explain the excess of monoallelic mutations

The report by Matos et al 1 brings up an issue of an excessive frequency of patients with hearing impairment (HI) in whom only monoallelic GJB2 mutations are identified by commonly used testing strategies. Interestingly, Matos et al suggest that these patients could harbour mutations in promoter of GJB2 which therefore should be included in the routine screening.1 This conclusion was supported by a novel sequence variant (−3438T→C) affecting GJB2 promoter function and found in a Portuguese patient in trans with a coding region mutation.1 The relatively high frequency of genotypes with monoallelic GJB2 mutations, such as the 35delG mutation, among the patients has indeed been noted previously2 3 although the exact size of this effect in relation to the generally high frequency of 35delG in Caucasians (carrier rates reaching 4%)4 has not been estimated. Although screening of promoter regions is clearly an attractive option in patients with monoallelic GJB2 defects, before it can be included in routine testing it should be shown that the −3438T→C or similar alteration(s) do indeed occur with an appreciable frequency. Given the report of Matos et al ,1 we were interested to find out: (1) whether there is an excess of monoallelic GJB2 mutations among patients with HI from our centre and if so, what is its magnitude, and (2) what is the frequency of GJB2 promoter mutations such as −3438T→C among such patients. Owing to the high frequency …
Candidate Genes for Oral-Facial Clefts in Guatemalan Families

Nonsyndromic cleft lip ± cleft palate (CL/P) is a complex trait of unknown etiology. Most genetic studies of CL/P define affection status in a way that ignores subtle subclinical manifestations, resulting in a potential loss of statistical power. This study investigated 10 candidate genes in 155 individuals from 25 Guatemalan CL/P families. High-resolution ultrasound images of the orbicularis oris (OO) muscle were obtained. CL/P was present in 28 family members; an additional 10 had subcutaneous OO muscle defects. Family-based association studies were performed for both narrow (CL/P only) and broad (CL/P plus OO muscle defects) definitions of affection status. PVRL1 was significantly associated under both definitions (P = 0.04, narrow; P = 0.02, broad). Association with JAG2 improved from P = 0.09 under the narrow definition to P = 0.04 under the broad definition. Broadening the oral-facial cleft phenotype to include subclinical variants may improve power in genetic studies.
Evoked slow muscarinic acetylcholinergic synaptic potentials in rat hippocampal interneurons

The hippocampus receives an extensive cholinergic input from the medial septal nucleus that ramifies throughout all layers and plays a pivotal modulatory role in cognitive function. Although the pharmacological effects of exogenous application of cholinergic agonists have been extensively studied in hippocampal neurons, much less is known about the effects of synaptically released acetylcholine (ACh). In this respect, most studies have focused on the cholinergic afferent input to pyramidal neurons that produces a characteristically slow depolarizing synaptic response mediated by activation of muscarinic ACh receptors (mAChRs). Here we report that cholinergic afferent stimulation also elicits atropine‐sensitive synaptic potentials in hippocampal CA1 interneurons but, in contrast to synaptic responses in pyramidal neurons, these are highly diverse in waveform, although can still be classified into five distinct subtypes. The most common response type (i) 64% of cells) consisted of a slow sustained membrane potential depolarization. The other 36% of responses could be subdivided into responses comprising of (ii) a biphasic membrane potential change in which an initial slow hyperpolarization subsequently transforms into a slow depolarization (20%), (iii) a pure, slow hyperpolarization (13%), and (iv) an oscillatory response persisting for several seconds (2%). Interestingly, there were also interneurons totally insensitive to both synaptic and pharmacological cholinergic challenge. Morphological investigation of recorded cells revealed no obvious correlation between responsiveness to cholinergic afferent stimulation and dendritic and axonal arborization. The current study suggests that synaptic release of ACh results in a complex and differential mAChR‐mediated modulation of cellular excitability within the hippocampal interneuron population. © 2006 Wiley‐Liss, Inc.
Age-related alterations of NMDA-receptor properties in the mouse forebrain: partial restoration by chronic phosphatidylserine treatment.

The effect of aging on the properties of N-methyl-D-aspartate (NMDA) receptors in the forebrain of female NMRI mice was investigated using the antagonist [3H]MK-801 as radioligand. Compared to young (3 months) mice, aged (20 months) mice showed changes of the properties of the NMDA receptor at three different levels: (1) the density was reduced by about 35%; (2) the efficacy of L-glutamate and glycine for stimulating specific [3H]MK-801 binding was enhanced, probably because more NMDA receptor-associated ion channels are closed under baseline conditions in the aged brain; (3) the affinity of L-glutamate and glycine to its binding sites at the NMDA receptor complex was also enhanced. Chronic treatment of aged mice with phosphatidylserine (20 mg/kg, i.p., once daily) for three weeks completely normalized enhanced efficacy and affinity of L-glutamate and glycine and elevated NMDA receptor density by approximately 25%. These findings are consistent with the assumptions that deficits of the NMDA receptor are one of the mechanisms of age-related cognitive impairment and that the beneficial effects of phosphatidylserine treatment on cognitive deficits of aged individuals might be partially due to the effects of this drug on age-related NMDA receptor deficits.
Striatal function in relation to negative symptoms in schizophrenia

Background Previous studies have suggested that motivational aspects of executive functioning, which may be disrupted in schizophrenia patients with negative symptoms, are mediated in part by the striatum. Negative symptoms have been linked to impaired recruitment of both the striatum and the dorsolateral prefrontal cortex (DLPFC). Here we tested the hypothesis that negative symptoms are associated primarily with striatal dysfunction, using functional magnetic resonance imaging (fMRI). Method Working-memory load-dependent activation and gray matter volumes of the striatum and DLPFC were measured using a region-of-interest (ROI) approach, in 147 schizophrenia patients and 160 healthy controls. In addition to testing for a linear relationships between striatal function and negative symptoms, we chose a second, categorical analytic strategy in which we compared three demographically and behaviorally matched subgroups: patients with a high burden of negative symptoms, patients with minimal negative symptoms, and healthy subjects. Results There were no differences in striatal response magnitudes between schizophrenia patients and healthy controls, but right DLPFC activity was higher in patients than in controls. Negative symptoms were inversely associated with striatal, but not DLPFC, activity. In addition, patients with a high burden of negative symptoms exhibited significantly lower bilateral striatal, but not DLPFC, activation than schizophrenia patients with minimal negative symptoms. Working memory performance, antipsychotic exposure and changes in gray matter volumes did not account for these differences. Conclusions These data provide further evidence for a robust association between negative symptoms and diminished striatal activity. Future work will determine whether low striatal activity in schizophrenia patients could serve as a reliable biomarker for negative symptoms.