Miracle-dz/UniFAR-FTUs huggingface dataset:
Cigarette Smoking during Pregnancy

Objectives To determine: 1. the prevalence of regular smoking in the latter half of pregnancy in a sample of Canadian prenatal patients; 2. the psycho-social and demographic characteristics that differentiate smoking from nonsmoking patients; 3. the characteristics that differentiate prenatal patients who smoke more than 10 cigarettes per day from those who smoke 1 to 10 cigarettes per day; and 4. the psychiatric morbidities or psychological attitudes associated with smoking in pregnancy. Methods Consecutive consenting women 20 or more weeks pregnant were given, at a prenatal clinic, the General Health Questionnaire (GHQ), the Fetal Health Locus of Control (FHLC), and a study questionnaire to complete. Results Five-hundred and forty-five women completed the questionnaires. Eighty-nine (16.3%) women reported regular daily cigarette smoking in the second half of pregnancy, while 43 (7.9%) smoked more than 10 cigarettes per day. Women who smoked were more likely than nonsmokers to be under 21, born in Canada, have only elementary education, be unemployed and unmarried, eat unhealthy diets, drink alcohol, use nonprescription and illicit drugs, have unplanned pregnancies, histories of emotional and physical problems, and have suffered physical abuse before and during pregnancy. Smokers were more likely than nonsmokers to meet case status on the GHQ and on the FHLC to believe “chance” and less likely to believe that “internal control” or “powerful others” affected the health of their fetuses. “Social disorganization”, “health risks”, and “poor health” factors accounted for 83.1% of the total variance. Conclusions Women who smoke in pregnancy have a higher rate than nonsmokers of other health risk behaviours, social disadvantage, and emotional disturbance. Psychiatrists can play an important role in identifying and treating emotional and psychiatric morbidity in women of reproductive age to facilitate a reduction in smoking rates in this high-risk population.
Comparison between bortezomib and rituximab in the treatment of antibody-mediated renal allograft rejection.

BACKGROUND Antibody-mediated rejection (ABMR) following kidney transplantation is associated with poor allograft survival. Conventional treatment based on plasmapheresis (PPH) and the administration of intravenous immunoglobulins (IVIG) is not satisfactory. Two compounds, more specifically targeting B cells and plasma cells, may help to improve the prognosis: rituximab, a B-cell-depleting monoclonal antibody, and bortezomib, a proteasome inhibitor causing apoptosis of plasma cells. METHODS Starting in February 2009, we treated 10 consecutive patients with ABMR according to current Banff criteria with one cycle of bortezomib [1.3 mg/m(2) intravenously (i.v.), Day 1, 4, 8, 11]. This group was compared to a historical control group of patients (n = 9) treated with a fixed single dose of rituximab (500 mg i.v.). All patients received PPH (6×) and IVIG (30 g). Patients with acute ABMR additionally received methylprednisolone (3 × 500 mg i.v.). RESULTS Patient survival in both groups was 100%. At 18 months after treatment, graft survival was 6/10 in the bortezomib group as compared to 1/9 functioning grafts in the rituximab group (P = 0.071). Renal function was superior in patients treated with bortezomib as compared to rituximab-treated patients (serum creatinine at 9 months: 2.5 ± 0.6 versus 5.1 ± 2.1 mg/dL, P = 0.008). Proteinuria was not different between both groups (9 months: 1.3 ± 1.0 versus 1.6 ± 1.6 g/day, P = n.s.). CONCLUSIONS Treatment of ABMR with bortezomib in addition to standard therapy was partially effective, whereas treatment with a fixed dose of rituximab in addition to standard therapy with PPH and IVIG did not result in sufficient long-term graft survival. In the future, new strategies including the combination of both substances and the application of higher doses must be discussed.
Advanced paternal age: How old is too old?

Average paternal age in the UK is increasing. The public health implications of this trend have not been widely anticipated or debated. This commentary aims to contribute to such a debate. Accumulated chromosomal aberrations and mutations occurring during the maturation of male germ cells are thought to be responsible for the increased risk of certain conditions with older fathers. Growing evidence shows that the offspring of older fathers have reduced fertility and an increased risk of birth defects, some cancers, and schizophrenia. Adverse health outcomes should be weighed up against advantages for children born to older parents, mindful that these societal advantages are likely to change over time.
Biodiversity and Biogeography of Rhizobia Associated with Soybean Plants Grown in the North China Plain

ABSTRACT As the putative center of origin for soybean and the second largest region of soybean production in China, the North China Plain covers temperate and subtropical regions with diverse soil characteristics. However, the soybean rhizobia in this plain have not been sufficiently studied. To investigate the biodiversity and biogeography of soybean rhizobia in this plain, a total of 309 isolates of symbiotic bacteria from the soybean nodules collected from 16 sampling sites were studied by molecular characterization. These isolates were classified into 10 genospecies belonging to the genera Sinorhizobium and Bradyrhizobium, including four novel groups, with S. fredii (68.28%) as the dominant group. The phylogeny of symbiotic genes nodC and nifH defined four lineages among the isolates associated with Sinorhizobium fredii, Bradyrhizobium elkanii, B. japonicum, and B. yuanmingense, demonstrating the different origins of symbiotic genes and their coevolution with the chromosome. The possible lateral transfer of symbiotic genes was detected in several cases. The association between soil factors (available N, P, and K and pH) and the distribution of genospecies suggest clear biogeographic patterns: Sinorhizobium spp. were superdominant in sampling sites with alkaline-saline soils, while Bradyrhizobium spp. were more abundant in neutral soils. This study clarified the biodiversity and biogeography of soybean rhizobia in the North China Plain.
A Phase I/II Trial of Pazopanib in Combination with Lapatinib in Adult Patients with Relapsed Malignant Glioma

Purpose: Increased mitogenic signaling and angiogenesis, frequently facilitated by somatic activation of EGF receptor (EGFR; ErbB1) and/or loss of PTEN, and VEGF overexpression, respectively, drive malignant glioma growth. We hypothesized that patients with recurrent glioblastoma would exhibit differential antitumor benefit based on tumor PTEN/EGFRvIII status when treated with the antiangiogenic agent pazopanib and the ErbB inhibitor lapatinib. Experimental Design: A phase II study evaluated the antitumor activity of pazopanib 400 mg/d plus lapatinib 1,000 mg/d in patients with grade 4 malignant glioma and known PTEN/EGFRvIII status not receiving enzyme-inducing anticonvulsants (EIAC). The phase II study used a two-stage Green–Dahlberg design for futility. An independent, parallel phase I component determined the maximum-tolerated regimen (MTR) of pazopanib and lapatinib in patients with grade 3/4 glioma receiving EIACs. Results: The six-month progression-free survival (PFS) rates in phase II (n = 41) were 0% and 15% in the PTEN/EGFRvIII-positive and PTEN/EGFRvIII-negative cohorts, respectively, leading to early termination. Two patients (5%) had a partial response and 14 patients (34%) had stable disease lasting 8 or more weeks. In phase I (n = 34), the MTR was not reached. On the basis of pharmacokinetic and safety review, a regimen of pazopanib 600 mg plus lapatinib 1,000 mg, each twice daily, was considered safe. Concomitant EIACs reduced exposure to pazopanib and lapatinib. Conclusions: The antitumor activity of this combination at the phase II dose tested was limited. Pharmacokinetic data indicated that exposure to lapatinib was subtherapeutic in the phase II evaluation. Evaluation of intratumoral drug delivery and activity may be essential for hypothesis-testing trials with targeted agents in malignant glioma. Clin Cancer Res; 19(4); 900–8. ©2012 AACR.
The Fanconi anemia pathway and ICL repair: implications for cancer therapy

Fanconi anemia (FA) is an inherited disease caused by mutations in at least 13 genes and characterized by genomic instability. In addition to displaying strikingly heterogenous clinical phenotypes, FA patients are exquisitely sensitive to treatments with crosslinking agents that create interstrand crosslinks (ICL). In contrast to bacteria and yeast, in which ICLs are repaired through replication-dependent and -independent mechanisms, it is thought that ICLs are repaired primarily during DNA replication in vertebrates. However, recent data indicate that replication-independent ICL repair also operates in vertebrates. While the precise role of the FA pathway in ICL repair remains elusive, increasing evidence suggests that FA proteins function at different steps in the sensing, recognition and processing of ICLs, as well as in signaling from these very toxic lesions, which can be generated by a wide variety of cancer chemotherapeutic drugs. Here, we discuss some of the recent findings that have shed light on the role of the FA pathway in ICL repair, with special emphasis on the implications of these findings for cancer therapy since disruption of FA genes have been associated with cancer predisposition.
A CATHARSIS OF THE UNITED KINGDOM’S POLITICAL AND ECONOMIC LANDSCAPE: POST BREXIT

This paper provides a critical theoretical review of the political factors, which significantly influenced the June 2016 Brexit decision to leave the European Union (EU). This paper also provides a critical investigation of the likely impact of Brexit on certain social, political and economic aspects of the UK landscape. To this end the paper also analyses the effect EU policies on the economy, migration, sovereignty and democracy had on Brexit views. During the 2014 European Parliament elections, the UK Conservative Party haemorrhaged electoral support to the United Kingdom Independence Party (UKIP). During the 2016 Brexit Referendum campaign, the ruling elite had an unfounded expectation that UK citizens would vote to remain in the EU. Under the policy vacuum of no change, the political mantra of UKIP became appealing to an increasing majority in the UK. The failure to ensure that UK citizens were informed of the finalised EU-UK Brexit deal before the referendum took place (as indicated in David Cameron’s 2013 Bloomberg speech) will prove to be telling. By August 2018 , the rationale that a second referendum should be held was overwhelming. The UK population will experience many of the significant elements of the political threats, which were made during ‘project fear’. The reality of post Brexit for many UK people will be quite different to the panacea they envisaged.
What Drives People to Complain about Environmental Issues? An Analysis Based on Panel Data Crossing Provinces of China

Strengthening public participation has often proven essential for achieving environmental sustainability goals. The “Xinfang”system, through complaint visits and letters, offers institutional channels through which the public’s grievances can be addressed, and where court judgments can be challenged by filing complaints about environmental problems to Environmental Protection Bureaus. Operating under the monopoly of the state Party, the “Xinfang” system provides the political opportunity for pro-environmental values and interests to be voiced and heard by governments. Importantly, comprehending the evolution of public complaints over a prolonged period of time sheds light on various determinants of this public participation program. This paper seeks to better understand environmental degradation caused by unbridled economic growth in China and the efforts that civic environmentalism has made to reduce the problem. More specifically, it uses panel data on 31 Chinese provincial/first level administrative units, collected over a decade, from 2003 to 2015, to analyze how socioeconomic status in the general public and the political and policy structures have shaped civic environmentalism. We use two Ordinary Least Squares (OLS) models to explore how these actors have propelled the public to protect their environment from discharged industrial wastewater, industrial waste gas, and solid wastes.
Eye movement abnormalities correlate with genotype in autosomal dominant cerebellar ataxia type I

We compared horizontal eye movements (visually guided saccades, antisaccades, and smooth pursuit) in control subjects (n = 14) and patients with three forms of autosomal dominant cerebellar ataxias type I: spinocerebellar ataxias 1 and 2 (SCA1, n = 11; SCA2, n = 10) and SCA3/Machado‐Joseph disease (MJD) (n = 16). In SCA1, saccade amplitude was significantly increased, resulting in hypermetria. The smooth pursuit gain was decreased. In SCA2, saccade velocity was markedly decreased. The percentage of errors in antisaccades was greatly increased and was significantly correlated with age at disease onset. In addition, a correlation between smooth pursuit gain and the number of trinucleotide repeats was found. In SCA3, gaze‐evoked nystagmus was often present as was saccade hypometria and smooth pursuit gain was markedly decreased. Three major criteria, saccade amplitude, saccade velocity, and presence of gaze‐evoked nystagmus, permitted the correct assignment of 90% of the SCA1, 90% of the SCA2, and 93% of the patients with SCA3 to their genetically confirmed patient group and, therefore, may help orient diagnose of SCA1, SCA2, and SCA3 at early clinical stages of the diseases.
Detection of abnormalities and electricity theft using genetic Support Vector Machines

Efficient methods for detecting electricity fraud has been an active research area in recent years. This paper presents a hybrid approach towards non-technical loss (NTL) analysis for electric utilities using genetic algorithm (GA) and support vector machine (SVM). The main motivation of this study is to assist Tenaga Nasional Berhad (TNB) in Malaysia to reduce its NTLs in the distribution sector. This hybrid GA-SVM model preselects suspected customers to be inspected onsite for fraud based on abnormal consumption behavior. The proposed approach uses customer load profile information to expose abnormal behavior that is known to be highly correlated with NTL activities. GA provides an increased convergence and globally optimized SVM hyper-parameters using a combination of random and prepopulated genomes. The result of the fraud detection model yields classified classes that are used to shortlist potential fraud suspects for onsite inspection. Simulation results prove the proposed method is more effective compared to the current actions taken by TNB in order to reduce NTL activities.
Reconciling Control of Carbon and Air Pollution with Economic Growth in China

The rapid economic growth in China over the past 30 years brings parallel degradation of the environment. Recently, China has adopted stringent environmental targets under the 11th Five Year Plan (FYP) for 2005-2010. In this paper, we develop links between a multi-sector economic CGE model, a detailed emissions inventory, an advanced atmospheric model (GEO-CHEM model), and a environmental health assessment tool (BenMAP model) to assess the costs and benefits of such 11th FYP policy measures, and then compare them with a hypothetical carbon tax. We find that, the 11th FYP SO2 policy appears to be an effective policy success for SO2 control over the time horizon of our assessment, leading to very large avoided damages to public health, and doing so at a sizable net benefit to Chinese consumption, investment, and GDP. A modest carbon tax, though achieving less SO2 reductions, it would substantially reduce carbon emissions, as well as other local air pollution as a broader multi-pollutant control policy than the11th FYP policies. There is a cost to GDP from a carbon tax policy; however, if the revenue is recycled back by reducing existing tax rates rather than the lump-sum transfer, the negative impact on GDP would be relatively smaller. Keywords: Five Year Plan (FYP), Carbon Tax, CGE Model, GEOS-CHEM, BENMAP JEL Classification Codes: C68; D58; H23; Q28
Differential emotion attribution to neutral faces of own and other races

ABSTRACT Past research has demonstrated differential recognition of emotion on faces of different races. This paper reports the first study to explore differential emotion attribution to neutral faces of different races. Chinese and Caucasian adults viewed a series of Chinese and Caucasian neutral faces and judged their outward facial expression: neutral, positive, or negative. The results showed that both Chinese and Caucasian viewers perceived more Chinese faces than Caucasian faces as neutral. Nevertheless, Chinese viewers attributed positive emotion to Caucasian faces more than to Chinese faces, whereas Caucasian viewers attributed negative emotion to Caucasian faces more than to Chinese faces. Moreover, Chinese viewers attributed negative and neutral emotion to the faces of both races without significant difference in frequency, whereas Caucasian viewers mostly attributed neutral emotion to the faces. These differences between Chinese and Caucasian viewers may be due to differential visual experience, culture, racial stereotype, or expectation of the experiment. We also used eye tracking among the Chinese participants to explore the relationship between face-processing strategy and emotion attribution to neutral faces. The results showed that the interaction between emotion attribution and face race was significant on face-processing strategy, such as fixation proportion on eyes and saccade amplitude. Additionally, pupil size during processing Caucasian faces was larger than during processing Chinese faces.
Crowdsourcing Without Profit: The Role of the Seeker in Open Social Innovation

Crowdsourcing has increasingly been studied as an open innovation (OI) mechanism by which organizations (seekers) engage with an external crowd of potential solvers. Previous crowdsourcing research has focused on solvers and their individual motivations, providing few insights as to why and how seekers use crowdsourcing, and how these choices affect the value that might be realized from these efforts. Prior research has also emphasized profit&#8208;seeking firms, despite the use of OI practices by public sector organizations to achieve societal benefits. This paper examines the organizational and project&#8208;level choices of government agencies that crowdsource from citizens to drive open social innovation, and thus develop new ways to address societal problems, a process sometimes termed &#8216;citizensourcing. &#8217; Using rich data from 18 local government seekers that use the same intermediary, we develop a model of seeker crowdsourcing implementation that links a previously unstudied variance in seeker intent and engagement strategies to differences in project team motivation and capabilities, in turn leading to varying online engagement behaviors and ultimately project outcomes. Our study compares and contrasts governmental and corporate crowdsourcing to reveal that the non&#8208;pecuniary orientation of both seekers and solvers means that the motives of government crowdsourcing are fundamentally different from corporate crowdsourcing, but the process in our sample more closely resembles that of a firm&#8208;sponsored community rather than government sponsored contests. More generally, we show how seeker organizational factors and choices shape project&#8208;level implementation and success of crowdsourcing efforts, as well as provide insights for OI activities of other smaller, geographically bound organizations.
"Do Animals Have Accents?": Talking with Agents in Multi-Party Conversation

In this paper we unpack the use of conversational agents, or so-called intelligent personal assistants (IPAs), in multi-party conversation amongst a group of friends while they are socialising in a café. IPAs such as Siri or Google Now can be found on a large proportion of personal smartphones and tablets, and are promoted as 'natural language' interfaces. The question we pursue here is how they are actually drawn upon in conversational practice? In our work we examine the use of these IPAs in a mundane and common-place setting and employ an ethnomethodological perspective to draw out the character of the IPA-use in conversation. Additionally, we highlight a number of nuanced practicalities of their use in multi-party settings. By providing a depiction of the nature and methodical practice of their use, we are able to contribute our findings to the design of IPAs.
Inflammatory monocytes and Fcγ receptor IV on osteoclasts are critical for bone destruction during inflammatory arthritis in mice

Destruction of bone tissue by osteoclasts represents a severe pathological phenotype during inflammatory arthritis and results in joint pain and bone malformations. Previous studies have established the essential role of cytokines including TNFα and receptor–ligand interactions, such as the receptor activator of nuclear factor-kappa B–receptor activator of nuclear factor-kappa B ligand interaction for osteoclast formation during joint inflammation. Moreover, autoantibodies contribute to joint inflammation in inflammatory arthritis by triggering cellular fragment crystallizable (Fc)γ receptors (FcγR), resulting in the release of proinflammatory cytokines and chemokines essential for recruitment and activation of innate immune effector cells. In contrast, little is known about the expression pattern and function of different FcγRs during osteoclast differentiation. This would allow osteoclasts to directly interact with autoantibody immune complexes, rather than being influenced indirectly via proinflammatory cytokines released upon immune complex binding to other FcγR-expressing innate immune cells. To address this question, we studied FcγR expression and function on osteoclasts during the steady state and during acute joint inflammation in a model of inflammatory arthritis. Our results suggest that osteoclastogenesis is directly influenced by IgG autoantibody binding to select activating FcγRs on immature osteoclasts, resulting in enhanced osteoclast generation and, ultimately, bone destruction.
Small mammals: paratenic hosts for species of Toxocara in eastern Slovakia

Abstract Toxocara spp. , an aetiological agent of a serious helminthozoonosis, is a common roundworm of domestic and wild carnivores worldwide. The study aimed to estimate the seroprevalence of Toxocara in small mammals from different localities in eastern Slovakia. Anti-Toxocara antibodies were detected in 6.4% out of 2140 examined animals trapped in eastern Slovakia. Due to their high density and observed high seroprevalence of toxocariasis, Apodemus agrarius, A. flavicollis, Myodes glareolus and Mus spicilegus (10.9, 4.2, 3.6 and 11.2%, respectively) represent important sources of the infection. A significant correlation between type of food and Toxocara positivity was detected: granivores (7.2%) and invertebratophages (7.1%) were positive more frequently than herbivores (2.1%). In the years monitored, cyclic changes of seroprevalence were observed. A higher prevalence of antibodies in the spring was followed by a decrease in summer. In autumn, seroprevalence started to rise and stayed at a similar level through the winter. Seroprevalence of the examined animals confirms their contact with Toxocara spp. and demonstrates the presence of the aetiological agent in the monitored locality. Areas with a high prevalence of infected animals present constant infectious pressure on definitive hosts, thus also increasing infection risk for humans and paratenic hosts. The study confirmed the contact of small mammals with Toxocara spp. and demonstrated the presence and circulation of an aetiological agent in the localities monitored in eastern Slovakia.