Miracle-dz/UniFAR-FTUs huggingface dataset:
Correlation of blood pressure with cognitive function tests ’ results in older people . Preliminary results of the Train Your Brain Study

Introduction. In healthy organism, BP level in the periphery should not influence on the effectiveness of regulation of intracranial blood pressure (BP) and hemodynamics. However, independence of these mechanisms could be disrupted during aging. Some hypothetical mechanisms describe how prolonged hypertension could affect cognitive functioning deterioration in older people. However, there is little evidence, which would confirm such coexistence between these variables. Aim. The aim of this study is to assess the level of correlation between results of cognitive tests with blood pressure level. Material and methods. In these preliminary studies 128 patients (21 men, mean age: 68.80, age range 58-88) were examined. Cognitive functioning was assessed by Mini–Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA) and Trail Making Test Part B (TMT B). Blood pressure: Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP), Mean Arterial Pressure (MAP) and Pulse Pressure (PP) were examined. Results. DBP, SBP and MAP were significantly and negatively correlated with verbal fluency subtest of MoCA (r = -0.1945, -0,2414 and -0.2373), respectively. In group comparison, normotensive participants pronounced approximately 1.8 words more than their hypertensive counterparts in Verbal Fluency subtest. However, other results were not statistically significant (p > 0.05). Conclusions. In these preliminary studies we examined correlation of blood pressure with cognitive function tests. Only verbal fluency subtest of MoCA results were significantly and negatively correlated with DBP, SBP and MAP. Longitudinal studies on larger samples are needed to estimate the level and direction of hypertension relations with cognitive functioning in older people. Gerontol Pol 2017; 25: 53-59)
REMEDIAL INTERVENTION BASED ON INSTRUCTIONAL MODEL

Remediation for students with learning difficulties in mathematics is commonly based on a behaviourist framework of learning. As a result, these students might acquire procedural knowledge but are weak in process skills and without sufficient conceptual understanding. This study was embarked on investigating teaching and learning process of a mathematics remediation classroom in which a teacher helped his five students to improve mathematical knowledge and process skills through a concrete-representation-abstract sequence. Using a case study research design, qualitative data was collected through observation, interview and students’ work, at a suburban primary school. The teacher encouraged his students to explore mathematical ideas through problem-solving and modelling. Throughout the activities, he used explicit instruction a student who often showed learning difficulties. He also used explicit instruction for other students but he gradually provided prompts to other students to think actively while they were engaged in hands-on activities. Initially, these students had difficulties manipulating objects and drawing due to lacking of conceptual understanding. An indirect approach to instruction motivated them to learn simple reasoning, making connections and representations. However, they did not show any improvement in communication. Hence, a mixed instructional approach might facilitate students in acquiring mathematical knowledge and process skills.
EFFECTS OF SUCROSE AND GROWTH REGULATORS ON THE MICROTUBERIZATION OFCIP POTATO ( SOLANUM TUBEROSUM ) GERMPLASM

The present experiment was aimed to study the effect of sucrose and growth regulators (kinetin and 6benzylaminopurine) on potato microtuber formation. For this purpose the Murashige and Skoog (MS) media, supplemented with different levels of sucrose concentration and growth regulators had been used. The result showed that MS medium with double level (60g) of sucrose without any growth regulator had significantly enhanced the tuber formation but T1 treatment (i.e.100g of sucrose) had no significant effect on tuber formation. It was revealed that sucrose had positive impacts on the microtuberization up to some extent but at very high concentration reduced the microtuber formation. The kinetin and 6benzylaminopurine (BAP) also enhanced the microtuber formation. Early tuber initiation was observed in kinetin treated plants as compared to other treatments and BAP treated plants showed increase in weight of microtubers. The study also revealed that increase in density of plantlets had negatively affected the number of microtuber formation but the kinetin and BAP had positive impacts to enhance the microtuber formation. Dark condition provides better response as compared to light condition. The two explants source (nodal and sprout explants) the nodal explants showed best results as compared sprout explants as tuber initiation and weight of microtuber.
Understanding Value Prediction through Complex Simulations

Through this paper we investigated the value locality degree present in real-worlds program, and extended the value locality concept to all general-purpose registers (MIPS architecture). Also we exploited this concept through a prediction mechanism of load instruction values from two distinct perspectives: producer-centric and memory-centric. To extract the maximum degree of load value locality we performed execution driven simulations on SPEC95 benchmarks with unbounded table sizes. The encouraging obtained results facilitate implementation of much simpler prediction structures (at most 32/64 locations), reducing the hardware cost and complexity.
Characterization of nutritional constituents of Garcinia morella seeds and seed oil

The chemical analysis of Garcinia morella seeds and seed oil have been carried out in order to determine the possibility of using them as a source of food and industrial oil. Proximal analysis showed that the seeds had a high amount of carbohydrates and were rich in oil (38.08 g/100g) but have low protein content. The physical properties of the oil extracts showed the state to be liquid at room temperature (25 ± 1 ̊C) and the colour of the oil, orange yellow. The specific gravity of the oil was 0.89±0.01. Among the chemical properties of the oil extracts, acid value (16.83±0.43 mg NaOH/ g), saponification number (258.06±0.42 mg KOH/ g oil), iodine value (39.89 ± 0.57 mg/100 g), free fatty acid (11.50 ± 0.94%), peroxide value (0.01 ± 0.81 mg/g oil) compared well with those of conventional edible oils. Gas chromatography analysis of the oil revealed the presence of ten different fatty acids such as myristic acid, palmitic acid, palmitoleic acid, stearic acid, oleic acid, linoleic acid, arachidic acid, behenic acid, heptadecanoic acid and the prominent ones were oleic acid (45.38%) and stearic acid (45.95%). Seed oil G. morella could be used as edible oil and also suitable for industrial applications. The oil showed antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa.
ELECTRO-OPTIC BUNCH ARRIVAL TIME MEASUREMENT AT FLASH

Optical synchronization systems, based on mode-locked erbium-doped fiber lasers whose pulses are distributed over length stabilized fiber links, are expected to be drift free and to provide femtosecond stability for the next generation of free electron lasers. In this paper we provide a comparison between the stability of two bunch arrival time monitors working on different principles. In the first type the bunch-induced signal in a broad-band beam pick-up invokes an amplitude modulation in a train of short laser pulses, which are detected with a photo diode and a fast ADC. The second type utilizes the electro-optic effect in a 175 μ m thick GaP crystal, placed 3 mm away from the electron beam. Both methods show excellent correlation over a change in the bunch compression and acceleration. The achieved arrival time jitter is 80 fs over 20 s, which is near the limit of the present RF stabilization at FLASH.
DESIGN OF A NOVEL INTEGRATED POLARIZATION BEAM SPLITTER

We propose an integrated polarization beam splitter based on a twodimensional photonic crystal of polymer cylinders in air, with a TE bandgap centered on a wavelength of λ=780nm. The novel design is tailored for two-photon absorption 3D laser direct writing in a polymeric photoresist. Using this fabrication method, we can obtain spatial features as small as 200 nm. Processing time can be as low as 15 minutes for a 300x300 μm processed area and an overall cost of ~15 eur. The device is comprised of a series of components such as linear waveguides, parabolic tapered waveguides and multimode interference couplers, in order to lower optical losses. In this paper, design steps and simulation results are presented and discussed. Experimental results supporting the chosen fabrication method and materials are presented and discussed in the form of a parametric study.
P o S ( L A T T I C E 2 0 1 4 ) 0 2 2 Measurement of thermodynamics using gradient flow

We analyze bulk thermodynamics and correlation functions of the energy-momentum tensor in pure Yang-Mills gauge theory using the energy-momentum tensor defined by the gradient flow and small flow time expansion. Our results on thermodynamic observables are consistent with those obtained by the conventional integral method. The analysis of the correlation function of total energy supports the energy conservation. It is also addressed that these analyses with gradient flow require less statistics compared with the previous methods. All these results suggest that the energy-momentum tensor can be successfully defined and observed on the lattice with moderate numerical costs with the gradient flow.
Power Enhancement from Solar PV Array Topologies under Partial Shading Condition

In this paper, various shading patterns of solar photovoltaic (PV) array topologies are studied. The main objective is to study the mismatches of power in PV modules for non-uniform irradiations. Wasted power and non-linearity in PV behaviors is due to shading. Under shaded conditions, the P-V and I-V behaviors exhibit non-linearity along by several load maxima. In this paper, the investigations of the optimal layout of PV modules in a PV array are worked out to provide maximum peak power point (PPP) and peak voltage point (PVP) under various shaded conditions. Two type of solar PV array formations e.g. Total cross tied (TCT-PVF) and Non-symmetrical (NS-PVF) are considered for various shaded patterns. The modeling of PV array for various types of topologies is done in MATLAB/Simulink environment. The extensive results have been taken on these topologies for partial shading patterns and analyzed, which proves the NS-PVF execution is better as compared to TCT-PVF for most of the shading patterns.
A Lean USB File System for Bare Machine Applications

USB file management systems for mass storage are supported on many platforms and commonly used today by a variety of applications. These file systems vary depending upon the underlying operating system and environment. We consider the design of a USB file system that is independent of any operating system or application environment. Specifically, we describe the design and development of a lean USB file system for supporting bare PC applications that run with no OS or kernel support of any kind, and give details of its architecture, design, and implementation. Our design leverages the design characteristics and inherent features of USB mass storage. Bare machine USB file management systems enable computer applications to access mass storage at run-time without the operating system and environmental dependencies of conventional file management systems.
CHILDREN ’ S LEARNING BEHAVIORS : PSYCHOMETRIC PROPERTIES OF THE PRESCHOOL LEARNING BEHAVIOR SCALE IN TURKEY

The purpose of the current study was to adapt the Preschool Learning Behaviors Scale (PLBS), which was developed by McDermott, Leigh, and Perry (2002) to Turkish and examine reliability and validation. The PLBS is a 29-item scale that is designed to assess the learningrelated behaviors of preschool children on three subscales: Competence/Motivation, Attention/Persistence, and Attitude Toward Learning. A total of 140 preschool children (59 girls, 81 boys) and their teachers were recruited in Istanbul for the current study. Children’s age ranged from 39 to 77 months (M= 62.56, SD= 8.52). Firstly, the PLBS was adapted to Turkish language and culture. The validity of the scale was measured by Confirmatory Factor Analysis and the difference between the Upper %27 and Lower %27 groups was tested. The internal reliability of the scale was calculated by Cronbach's alpha and McDonald’s Omega method. The results of the Confirmatory Factor Analyses showed that the scale has a three-factor structure as in the original version. The CFA model for the PLBS confirmed that there is a 3-factor model (χ2= 699.443 (p < .001), CFI= 0.95, RMSEA= . 07 (.07 to .09 at 90% CI), and WRMR = 1.20. Cronbach alpha and McDonald’s Omega for internal consistency showed the measure was reliable. The analyses showed that the PLBS is a valid, reliable tool for Turkish children.
Assessment of Failure Strength of Real Alumina Foams with Use of the Periodic Structure Model

The subject of the study are alumina foams produced by gelcasting method. The results of micro-computed tomography of the foam samples are used to create the numerical model reconstructing the real structure of the foam skeleton as well as the simplified periodic open-cell structure models. The aim of the paper is to present a new idea of the energy-based assessment of failure strength under uniaxial compression of real alumina foams of various porosity with use of the periodic structure model of the same porosity. Considering two kinds of cellular structures: the periodic one, for instance of fcc type, and the random structure of real alumina foam it is possible to justify the hypothesis, computationally and experimentally, that the same elastic energy density cumulated in the both structures of the same porosity allows to determine the close values of fracture strength under compression. Application of finite element computations for the analysis of deformation and failure processes in real ceramic foams is time consuming. Therefore, the use of simplified periodic cell structure models for the assessment of elastic moduli and failure strength appears very attractive from the point of view of practical applications.
The mouse Id 2 and Id 4 genes : structural organization and chromosomal localization

The Id proteins belong to a family of nuclear HLH proteins lacking a basic region and thought to function as dominantnegative regulators of bHLH proteins during cell growth and differentiation. In this paper, we report the genomic organization of the mouse Id2 and Id4 genes. These genes each span approximately 3 kb of the mouse genome and are each organized as three exons with recognizable splice donor and acceptor consensus sequences. Their genomic organization is very similar, consistent with their having evolved from a common, ancestral Id-like gene. Using FISH analysis, we have localized the mouse Id2 and Id4 genes to mouse chromosome 12 and 13, respectively. © 1998 Published by Elsevier Science B.V. All rights reserved.
Inside the Box of Open Innovation : Actual Implementation in Large Firms

Since Chesbrough (2003)’s seminal work, “open innovation” (OI) is a buzzword that many companies and academics constantly refer to. This paper addresses the question of implementation of outside-in open innovation, and analyzes how companies adopting this approach implement it in terms of partnership development and internal organization. To do so, we rely on OI and strategic alliances literature. We then conduct a multiple case study analysis on 18 companies famous for their OI practices. We study what impact OI approaches had on their innovation methods, their way of managing partners, and their internal organization. We thus show that OI approaches are not always based on an extensive openness of external partnerships, and that companies can choose among three OI strategies: topic-oriented OI, partner-oriented OI or fully open approaches, which are not mutually exclusive. We also show they face a trade-off between breadth and depth of partnerships, which evolves over time. As for internal organization structures to handle OI approaches, we find that companies usually dedicate staff and budget resources to the project at the beginning of the process. When this new culture is widely developed and the OI approaches mature enough, it does no longer require any specific staff or department.
Capital Structure of Nonprofit Organisations : A Dynamic Framework

The existing literature on nonprofit capital structure is sparse and principally focuses on static theories. This paper takes a novel approach and models capital structure in a dynamic framework, mirroring recent work in the for-profit literature. This is motivated by the fact that, given the restricted nature of nonprofit organisation (NPO) capital, it is false to assume that observed leverage ratios are optimal and instead we should model the process as an adjustment to an organisation specific time varying target. Using a sample of 8380 US NPOs, this study presents estimates of the speed of adjustment suggesting somewhat high adjustment costs. We also show that agency costs, financial deficit and cash flow are important in determining target capital structure and the decision to borrow. Acknowledgment : The author would like to thank the National Center for Charitable Statistics for providing the data, St Catharine’s College Cambridge University for funding. Personally the author would like to thank Professor Marc Jegers for helpful comments, Amir Girgis for discussions and Vera Schoeller for editing. This paper is the culmination of work by the author while an undergraduate at Cambridge University and during graduate study at the London School of Economics. E-mail address: Yuri.Khodjamirian@gmail.com
Bacteriological profile and antibiotic resistance patterns of Podiatric infections in Diabetic patients-A Prospective study

The mono microbial and polymicrobial populations in diabetic foot infections are developing much resistance to antibiotics and they are hard to treat. The emergence of ESBL producers, carbapenemase producers among Enterobacteriacae, methicillin resistance and Inducible clindamycin resistance in Staphylococcus aureus, Multidrug resistance Acinetobater baumannii are commonly associated with morbidity and mortality in many cases. This prospective study aims in determining the multi drug resistance of microbial populations among diabetics over a period of time. The study was conducted for a period of one year and 575 patients were included in the study, out of which 76% were males and 24% were females. Among 417 patients with bacterial infections, 79.13% had Mono microbial infection and 20.87% had poly microbial infection, with 82.49% Gram negative bacteria and 17.50% Gram positive bacteria. Patients with repeated infections had To Conclude, Gram Negative bacteria were predominant in our study with more ESBL producers (18.89%) and carbapenemase produces (28.48%). Among Gram positive bacteria, methicillin resistant Staphylococcus aureus and Inducible clindamycin resistant Staphylococcus aureus were reported more . Organisms have developed resistance to most of the second & third generation cephalosporin. Aminoglycosides resitance was also seen in many cases. Carbapenemase once being choice of physicians in treating severe infection have also gained resistance.
Deposited in DRO : 30 October 2018 Version of attached le : Published Version Peer-review status of attached

Citation for published item: Malden, Stephen and Hughes, Adrienne. R. and Gibson, Ann-Marie and Bardid, . Farid and Androutsos, Odysseas and Craemer, Marieke De and Manios, Yannis and Summerbell, Carolyn and Cardon, Greet and Reilly, John. J. (2018) 'Adapting the ToyBox obesity prevention intervention for use in Scottish preschools : protocol for a feasibility cluster randomised controlled trial. ', BMJ open. , 8 (10). e023707.
Effect of gentamicin on the histology of renal tubules in different doses, Experimental study

The present study showed that the gentamicin cause a mild effect to the proximal convoluted tubules at dose of 5 mg/kg for 14 days represented by loss of brush border. Vacuoles of various sizes appeared with flattening and dilatation of the tubules, condensation of nuclear chromatin was observed, with partial detachment of the cells from the basement membrane. In comparison the more clear effect of gentamicin appears at 10 mg/kg dose that included loss of apical surface and detachment of cells from the basement membrane, with nearly complete loss of brush border and increase in number & size of the cytoplasmic vacuoles. Many nuclei with condensed chromatin and nuclear fragmented cells (apoptosis) were located in tubular lumen. The study concluded that gentamicin has adverse effect on the kidney and renal tubules histology especially in the high dose administration, comparison with low dose that reveal to mild damage.
Disclosure quality and corporate governance : Evidence from the French Stock Market Chiraz

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Disclosure quality and corporate governance: Evidence from the French Stock Market Chiraz Ben Ali
The primosomal protein DnaD inhibits cooperative DNA binding by the 2 replication initiator DnaA in Bacillus subtilis 3 4 5

27 DnaA is a AAA+ ATPase and the conserved replication initiator in bacteria. Bacteria control 28 the timing of replication initiation by regulating the activity of DnaA. DnaA binds to multiple 29 sites in the origin of replication (oriC) and is required for recruitment of proteins needed to load 30 the replicative helicase. DnaA also binds to other chromosomal regions and functions as a 31 transcription factor at some of these sites. Bacillus subtilis DnaD is needed during replication 32 initiation for assembly of the replicative helicase at oriC and during replication restart at stalled 33 replication forks. DnaD associates with DnaA at oriC and at other chromosomal regions bound 34 by DnaA. Using purified proteins, we found that DnaD inhibited the ability of DnaA to bind 35 cooperatively to DNA and caused a decrease in the apparent dissociation constant. These effects 36 of DnaD were independent of the ability of DnaA to bind or hydrolyze ATP. Other proteins 37 known to regulate B. subtilis DnaA also affect DNA binding, whereas much of the regulation of 38 E. coli DnaA affects nucleotide hydrolysis or exchange. We found that the rate of nucleotide 39 exchange for B. subtilis DnaA was rapid and not affected by DnaD. The rapid exchange is 40 similar to that of Staphylococcus aureus DnaA and in contrast to the slow exchange rate of 41 Escherichia coli DnaA. We suggest that organisms in which DnaA has a rapid rate of nucleotide 42 exchange predominantly regulate the DNA binding activity of DnaA and those with slow rates of 43 exchange regulate hydrolysis and exchange. 44