Miracle-dz/UniFAR-FTUs huggingface dataset:
Victim awareness

‘Ensuring offenders' awareness of the effects of crime on the victims of crime and the public’ is one of five stated aims of the National Probation Service of England and Wales and specifically undertaking victim awareness work is an expectation of the service’s work. The nature and putative value of such work appears to be rarely questioned however. It is argued that ‘victim awareness’ is a confused concept in terms of its rationale, definition, and empirical basis as a criminogenic need. These issues are evaluated and the practice implications discussed. A possible model of victim awareness work is described.
Intra-Organizational organizational Knowledge Networks In in A a Multinational Company

This study focuses on a challenge faced by multinational companies: how to enhance knowledge sharing across national and divisional boundaries. Through an in-depth qualitative analysis, this article illustrates how cross-functional and -cultural virtual teams based on identified internal network structures assist in integrating the knowledge of sales, marketing, and R&D people. Moreover, the present paper demonstrates how the multinational company can create effective spaces and processes for knowledge sharing networks where their employees can both access knowledge and provide it to others, thus mitigating the negative effect of physical and cultural distance on the availability of support and information.
AO Oyekan ligand , on the haemodynamics of glycerol-induced renal failure in rats α Effects of fenofibrate , a PPAR -

The modulating effect of peroxisome proliferator-activated receptor a ligand on haemodynamic effects of phenylepherine (PE), angiotensin II (AII), endothelin 1 (ET1), acetylcholine (Ach), sodium nitroprusside (SNP) and isoproterenol (ISO) were evaluated in glycerol-induced acute kidney injury in rats. The effect of PE on fenofibrate-treated animals was a dose-dependent increase in mean arterial blood pressure (MAP). For AII and ET1, MAP was also increased for the fenofibrate group but not in a dose-dependent fashion. On the medullary blood flow (MBF), while the lower doses of PE and AII increased the perfusion unit on the fenofibrate-treated group, the higher doses decreased the perfusion unit. The ET1 increased the perfusion unit on this group but not in dose-dependent fashion. The effects of PE and AII on the cortical blood flow (CBF) of fenofibrate-treated group is similar to that of MBF for the same group but not for ET1. The effect of Ach, SNP and ISO in all the groups was the decrease in MAP. ISO caused dose-dependent increase in MBF of fenofibrate-treated group. The effect of Ach, SNP and ISO on the CBF perfusion unit was that of the increase for the fenofibratetreated group. The study showed that fenofibrate did not attenuate increased blood pressure induced by PE, AII and ET1 but caused enhanced vasodilation by Ach, SNP and ISO.
Modelling streamflow response to climate change for the Kyeamba Creek catchment of south eastern Australia

This study predicts the probable impacts of climate change on the streamflow of Kyeamba Creek catchment of south eastern Australia. Three climate scenarios (B1, A1B and A2) and the average of four general circulation models (CNRM-CM3, CSIRO-MK3.5, ECHam5 and MIROC3.2) were used to simulate the streamflow for three future periods (2030, 2050 and 2090). Soil and Water Assessment Tool (SWAT) was calibrated for streamflow of both daily and monthly time steps. Nash-Sutcliffe Efficiencies (NSE) of 0.602 and 0.657 for calibration and validation, respectively, for monthly time step indicate good agreement between measured and simulated flow for the catchment. Comparing with the long time observed streamflow, simulated future annual average streamflow showed a variation ranging from +16% to –44%. Based on SWAT simulations of this study, Kyeamba Creek will likely experience small change in streamflow by the middle of the 21st century but big change by the end of this century.
PDFlib PLOP: PDF Linearization, Optimization, Protection Page inserted by evaluation version

An 8-month-old girl and a 20-month-old boy who presented with motor and developmental delay and long-standing fever are presented. The patients were diagnosed as Angelman syndrome with fluorescence in situ hybridization (FISH) analysis. Despite extensive clinical and laboratory examinations, no inflammatory or infectious origin for the fever was found. It was considered that the long-standing fever observed in these cases was due to hypothalamic dysfunction for thermoregulation.
Implicit Relational Assessment Procedure (IRAP): An Examination of the Impact of Response Options Theoretically Deemed as Contextual Relations versus Relational Coherence Indicators

The aims of the current research programme were to investigate the use of different response options (e.g., contextually cued relational responding (Crels) or relational coherence indicators (RCIs)) in the implicit relational assessment procedure (IRAP). In each of the four studies, participants (total N=124) completed two Pleasant-Unpleasant IRAPs in varying order and Consistent relations ('Pleasant-Positive') were contrasted with Inconsistent relations ('Unpleasant-Positive'). Study 1 (N=40) employed the response options “Same”/“Opposite” (Crels) versus “Accurate”/ “Inaccurate” (RCIs). The results of both IRAPs in this study indicated an ‘IRAP effect’ (bias) favouring 'Consistent' verbal relations, as expected. There was a statistically significant difference when data from both IRAPs were compared, indicating an effect for type of response option used. That is, the overall D-IRAP score for the Crel-IRAP was significantly greater than that of the RCI-IRAP. A significant interaction effect between the type of response option employed, order of congruent/incongruent blocks, and order of completion was also revealed. Study 2 (N=40) was similar to Study 1 except that the RCI response options employed on this occasion were “Right”/“Wrong”. Results revealed that responding across both IRAPs was mediated by a congruent bias and that there was a significant difference between participant data for the two IRAPs, with the Crel-IRAP producing a greater overall D-IRAP score. The sole difference between Study 3 (N=24) and the preceding studies, was the use of “True”/”False” as RCI response options. Again, the results indicated that responding was mediated by a congruent bias in both IRAPs. The findings also revealed that the overall D-IRAP score of the Crel-IRAP was significantly greater than that of the RCI-IRAP. Given the findings in studies 1, 2, and 3, in which there was a significant between the two IRAPs, Study 4 (N=20) attempted to clarify if completing two immediately successive IRAPs would in itself impact participant data. To this end, the response options were held constant across both IRAPs on this study (i.e. both used Crel response options; “Same”/ “Opposite”). Participant data in both IRAPs showed an IRAP effect which was ‘consistent’ with natural verbal relations. There was no significant difference between participant data from both IRAPs and analyses did not indicate that completing two successive IRAPs in one sitting impacted participant data. Taken overall, these exploratory research studies provide support for the effect of type of response options used on IRAP outcomes, and tentatively corroborate the proposal that RCIs may have a distinct function from Crels under certain circumstances.
Assessment of tumor prevention in Type 1 Neurofibromatosis using a nitroxide compound

Background Type 1 Neurofibromatosis (NF1) is a genetic disorder linked to mutations of the NF1 gene. Clinical symptoms are varied, but hallmark features of the disease include skin pigmentation anomalies (cafe au lait macules, skinfold freckling) and dermal neurofibromas. Method These dermal manifestations of NF1 have previously been reported in a mouse model where Nf1+/− mice are topically treated with dimethylbenz[a]anthracene (DMBA) and 12-O-tetradecanoylphorbol-13-acetate (TPA). We adopted this mouse model to test the protective effects of a nitroxide antioxidant, 5-carboxy-1,1,3,3-tetramethylisoindolin-2-yloxyl (CTMIO). Antioxidants have previously been shown to increase longevity in nf1-deficient fruitflies. Doses of 4 μM and 40 μM CTMIO provided ad libitum in drinking water were given to Nf1-deficient mice. Results Consistent with previous reports, Nf1-deficient mice showed a 4.7-fold increase in papilloma formation (P < 0.036). However, neither dose of CTMIO had any significant affect on papilloma formation. A non-significant decrease in skin pigmentation abnormalities was seen with 4 μM but not 40 μM CTMIO. Subsequent analysis of genomic DNA isolated from papillomas indicated that DMBA/TPA induced tumors did not exhibit a local loss of heterozygosity (LOH) at the Nf1 locus. Conclusion These data reveal that oral antioxidant therapy with CTMIO does not reduce tumor formation in a multistage cancer model, but also that this model does not feature LOH for Nf1.
The effect of conservatism on cost of capital: MENA evidence

The purpose of this article is to investigate the economic consequences of accounting conservatism in the Middle Eastern and North African (MENA) region. In particular, motivated by the lack of such studies in the context of emerging countries, we empirically examine the effect of conditional conservatism on firms’ cost of equity capital. Using a sample of firms pertaining to 13 MENA countries during the period 2004–2007, we conduct three sets of tests. First, we assess the existence of conservatism in our sample following the model of Basu (1997). Second, we examine the association between conservatism and cost of equity capital. Third, we test the effect of two disaggregated measures of conservatism – conservatism with respect to bad news (BNEWS) and conservatism with respect to good news (GNEWS) on the cost of equity. Results suggest that, overall firms in MENA region adopt conservative reporting. Furthermore, as predicted we find a negative association between conditional conservatism and the cost of equity capital. This evidence is robust to time series changes of variables and cross-country differences. The results also report a negative association between the two disaggregated measures of conservatism and the cost of equity capital. Our article gives additional light on the benefits of accounting conservatism.
Giardia lamblia regulates variant surface protein gene expression in A microRNA derived from an apparent canonical biogenesis pathway Material

We have previously shown that a snoRNA-derived microRNA, miR2, in Giardia lamblia potentially regulates the expression of 22 variant surface protein (VSP) genes. Here, we identified another miRNA, miR4, also capable of regulating the expression of several VSPs but derived from an unannotated open reading frame (ORF) rather than a snoRNA, suggesting a canonical miRNA biogenesis pathway in Giardia. miR4 represses expression of a reporter containing two miR4 antisense sequences at the 39 UTR without causing a corresponding decrease in the mRNA level. This repression requires the presence of the Giardia Argonaute protein (GlAgo) and is reversed by 29 O–methylated antisense oligo to miR4, suggesting an RNA-induced silencing complex (RISC)–mediated mechanism. Furthermore, in vivo and in vitro evidence suggested that the Giardia Dicer protein (GlDcr) is required for miR4 biogenesis. Coimmunoprecipitation of miR4 with GlAgo further verified miR4 as a miRNA. A total of 361 potential target sites for miR4 were bioinformatically identified in Giardia, out of which 69 (32.7%) were associated with VSP genes. miR4 reduces the expression of a reporter containing two copies of the target site from VSP (GL50803_36493) at the 39 UTR. Sixteen of the 69 VSP genes were further found to contain partially overlapping miR2 and miR4 targeting sites. Expression of a reporter carrying the two overlapping sites was inhibited by either miR2 or miR4, but the inhibition was neither synergistic nor additive, suggesting a complex mechanism of miRNA regulation of VSP expression and the presence of a rich miRNAome in Giardia.
Induced macromutations in horsegram [Macrotyloma uniflorum (Lam.) Verdc]

Genetic variability is the prerequisite for any crop to be improved. Mutation breeding is a best method identified to enhance the genetic variability in crops within short time. Knowing the limited variability in horsegram, present investigation was undertaken for the improvement in this crop by utilizing the variety Dapoli Kulthi-1. To induce variations, gamma radiation (100-600 Gy) and EMS (0.2 to 0.6%) separately and in combination of both were applied and the effect on seed germination as seedling damages were assessed in M1 generation. With increase in doses of mutagenic treatment, gradual reduction in seed germination, root length, shoot length and seedling height was recorded. In M2 generation the mutagenic treatments with lower doses were stimulative, while higher doses had inhibitory effect on chlorophyll and morphological mutations. Various viable macro mutations were scored for plant height, primary branches, pods per plant, seeds per pod, pod length, 1000 grain weight and yield per plant in M2 population.
Influence of the approach boundary layer on the flow over an axisymmetric hill at a moderate Reynolds number

Large Eddy Simulations of a flow at a moderate Reynolds number over and around a three-dimensional hill have been performed. The main aim of the simulations was to study the effects of various inflow conditions (boundary layer thickness and laminar versus turbulent boundary layers) on the flow behind the hill. The main features of the flow behind the hill are similar in all simulations, however various differences are observed. The topology of the streamlines (friction lines) on the surface adjacent to the lower wall was found to be independent of the inflow conditions prescribed and comprised four saddle points and four nodes (of which two are foci). In all simulations a variety of vortical structures could be observed, ranging from a horseshoe vortex - that was formed at the foot of the hill - to a train of large hairpin vortices in the wake of the hill. In the simulation with a thick incoming laminar boundary layer also secondary vortical structures (i.e. hairpin vortices) were observed to be formed at either side of the hill, superposed on the legs of the horseshoe vortex. Sufficiently far downstream of the hill, at the symmetry plane the mean velocity and the rms of the velocity fluctuations were found to become quasi-independent of the inflow conditions, while towards the sides the influence of the hill decreases and the velocity profiles recover the values prevailing at the inflow.
porphyrin-based antioxidant enzyme mimic therapeutic potential of HSJ-0017 , a novel Mn in vivo enzyme-mimic activity and In vitro

Manganese (III) 5, 10, 15, 20-tetrakis [3-(2-(2-methoxy)-ethoxy) ethoxy] phenyl porphyrin chloride, designated HSJ-0017, is a novel antioxidant enzyme mimic. The aim of the present study was to investigate the enzyme-mimic activity and the therapeutic potential of HSJ-0017 in free radical-related diseases. Superoxide dismutase (SOD) mimic activity was measured by the nitroblue tetrazolium chloride monohydrate reduction assay. Catalase (CAT) mimic activity was measured based on the decomposition of hydrogen peroxide. The antitumor, radioprotective and chemoprotective effects of HSJ-0017 were evaluated in H22 or S180 tumor-bearing Kunming mice. The anti-inflammatory and hepatoprotective effects were, respectively, evaluated in histamineinduced edema model and CCl4-induced hepatic damage model in Wistar rats. HSJ-0017 over a concentration range of 0.001– 10 mmol/L significantly inhibited the generation of superoxide anion. Significant hydrogen peroxide scavenging activity was observed when the concentration of HSJ-0017 was higher than 0.01 mmol/L. HSJ-0017 at a dose of 3.0 mg/kg exhibited significant antitumor effect on S180 tumor xenografts, whereas no significant antitumor effect was observed in H22 tumor xenografts. HSJ0017 at a dose of 3.0 mg/kg enhanced the antitumor effects of radiotherapy and chemotherapy, and reduced their toxicity. However, HSJ-0017 counteracted the antitumor effects of radiotherapy when administered simultaneously with radiotherapy. HSJ-0017 showed significant anti-inflammatory and hepatoprotective effects. Our results demonstrate that HSJ-0017 exhibits antioxidant, antitumor, anti-inflammatory, radioprotective, chemoprotective, and hepatoprotective effects. It is a potent dual
Productivity of Stump Harvesting for Fuel

Abstract The productivity of harvesting stump and root wood was studied in Norway spruce (Picea abies) stands. The objective was to create productivity models (m3/E0h) for stump wood extraction, stump wood forwarding, and site preparation, in addition to identifying work phases and improvement opportunities in the extraction and forwarding chain. Productivity models were based on time studies with professional operators. The independent variables in stump wood extraction were stump diameter (cm) and the number of stumps per hectare. For forwarding, the independent variables were volume of stump wood removed (m3/ha) and forwarding distance (m). When removing 350 stumps per ha with an average diameter of 40 cm, productivity was estimated at 7.9 m3/E0h. Increasing the number of stumps removed from 350 to 800 stumps per ha, increased productivity to 10.8 m3/E0h. Forwarding productivity was 7.8 m3/E0h with a forwarding distance of 250 m and a load size of 7.0 m3 when removing 60 m3 of stumps per ha.
Genetic characterization of Polish cultured brook trout, Salvelinus fontinalis (Mitchill), based on microsatellite DNA analysis

Genetic characterization of Polish cultured brook trout, Salvelinus fontinalis (Mitchill), based on microsatellite DNA analysis The genetic variability of two farmed strains of brook trout, Salvelinus fontinalis (Mitchill), was examined using six microsatellite DNA loci. The objective of the present study was to evaluate locus-specific genetic markers in brook trout strains cultured in Poland and to assess their levels of genetic diversity. The average number of alleles at all loci in the studied stocks differed between the two groups: 2.20 in the Rutki strain and 7.20 in the Canada strain. For the microsatellites examined, the number of alleles per locus ranged from 1 (locus Ssa-171 in the Canada strain) to 24 (locus Sfo-292 in the Canada strain). The results suggested that the Canada strain had higher gene diversity than the Rutki strain. The molecular analysis described in the present study will be useful for monitoring long-term genetic variation and for the identification of suitable parents for the development of stocks with suitable gene diversity in cultured Polish brook trout. Charakterystyka genetyczna pstrąga źródlanego (Salvelinus fontinalis Mitchill) hodowanego w Polsce przy zastosowaniu mikrosatelitarnych fragmentów DNA Przedmiotem opisywanych badań była analiza genetyczna dwóch stad pstrąga źródlanego Salvelinus fontinalis. Głównym celem badań było zidentyfikowanie alleli w wybranych loci mikrosatelitarnego DNA, charakterystycznych dla dwóch stad pstrąga źródlanego, pochodzących z Zakładu Hodowli Ryb Łososiowatych w Rutkach Instytutu Rybactwa Śródlądowego w Olsztynie. Średnia liczba alleli w analizowanych loci u badanych ryb wynosiła od 2,20 (stado Rutki) do 7,20 (stado Canada). Liczba alleli w badanych loci wynosiła od 1 (locus Ssa-171 dla stada Canada) do 24 (locus Sfo-292 dla stada Canada). W wyniku przeprowadzonych analiz stwierdzono, iż stado Canada charakteryzowało się wyższą zmiennością genetyczną w porównaniu do stada Rutki. Opisaną metodę przy zastosowaniu markerów mikrosatelitarnego DNA można wykorzystać do monitoringu genetycznego w trakcie prowadzenia prac hodowlanych.
Dynamic Web Services Composition using Optimization Approach

In recent time, large number of web services is published over the web. Several issues are faced by end users i.e. when single services is unable to fulfil the requirement, when more than one services provide the same functionality or when there is a need of optimal solution. Dynamic web services composition facilitates users to generate value added services from the existing one at runtime. Use of QoS parameters with web services plays vital role to select the most relevant solution when same functionality provided by multiple candidate solutions. Genetic programming along with QoS-based service composition provides optimal solution with assurance. In this context, our work presents an optimization based approach for dynamic web service composition that takes into account the quality of service model. The proposed approach utilizes a Genetic Algorithm to generate the optimal composition.
Nitrogen‐Doped Carbon Encapsulated Mesoporous Vanadium Nitride Nanowires as Self‐Supported Electrodes for Flexible All‐Solid‐State Supercapacitors

Flexible 3D nanoarchitectures have received tremendous interest recently because of their potential applications in flexible/wearable energy storage devices. Herein, 3D intertwined nitrogen‐doped carbon encapsulated mesoporous vanadium nitride nanowires (MVN@NC NWs) are investigated as thin, lightweight, and self‐supported electrodes for flexible supercapacitors (SCs). The MVN NWs have abundant active sites accessible to charge storage, and the N‐doped carbon shell suppresses electrochemical dissolution of the inner MVN NWs in an alkaline electrolyte, leading to excellent capacitive properties. The flexible MVN@NC NWs film electrode delivers a high areal capacitance of 282 mF cm−2 and exhibits excellent long‐term stability with 91.8% capacitance retention after 12 000 cycles in a KOH electrolyte. All‐solid‐state flexible SCs assembled by sandwiching two flexible MVN@NC NWs film electrodes with alkaline poly(vinyl alcohol) (PVA), sodium polyacrylate, and KOH gel electrolyte boast a high volumetric capacitance of 10.9 F cm−3, an energy density of 0.97 mWh cm−3, and a power density of 2.72 W cm−3 at a current density of 0.051 A cm−3 based on the entire cell. By virtue of the excellent mechanical flexibility, high capacitance, and large energy/power density, the self‐supported MVN@NC NWs paper‐like electrodes have large potential applications in portable and wearable flexible electronics.
Connector-Breaker Games on Random Boards

By now, the Maker-Breaker connectivity game on a complete graph $K_n$ or on a random graph $G\sim G_{n,p}$ is well studied. Recently, London and Pluhár suggested a variant in which Maker always needs to choose her edges in such a way that her graph stays connected. By their results it follows that for this connected version of the game, the threshold bias on $K_n$ and the threshold probability on $G\sim G_{n,p}$ for winning the game drastically differ from the corresponding values for the usual Maker-Breaker version, assuming Maker's bias to be 1. However, they observed that the threshold biases of both versions played on $K_n$ are still of the same order if instead Maker is allowed to claim two edges in every round. Naturally, this made London and Pluhár ask whether a similar phenomenon can be observed when a $(2:2)$ game is played on $G_{n,p}$. We prove that this is not the case, and determine the threshold probability for winning this game to be of size $n^{-2/3+o(1)}$.