Miracle-dz/UniFAR-FTUs huggingface dataset:
An In Silico Study of the Antioxidant Ability for Two Caffeine Analogs Using Molecular Docking and Quantum Chemical Methods

The antioxidant activity of molecules constitutes an important factor for the regulation of redox homeostasis and reduction of the oxidative stress. Cells affected by oxidative stress can undergo genetic alteration, causing structural changes and promoting the onset of chronic diseases, such as cancer. We have performed an in silico study to evaluate the antioxidant potential of two molecules of the zinc database: ZINC08706191 (Z91) and ZINC08992920 (Z20). Molecular docking, quantum chemical calculations (HF/6-31G**) and Pearson’s correlation have been performed. Molecular docking results of Z91 and Z20 showed both the lower binding affinity (BA) and inhibition constant (Ki) values for the receptor-ligand interactions in the three tested enzymes (cytochrome P450—CP450, myeloperoxidase—MP and NADPH oxidase—NO) than the control molecules (5-fluorouracil—FLU, melatonin—MEL and dextromethorphan—DEX, for each receptor respectively). Molecular descriptors were correlated with Ki and strong correlations were observed for the CP450, MP and NO receptors. These and other results attest the significant antioxidant ability of Z91 and Z20, that may be indicated for further analyses in relation to the control of oxidative stress and as possible antioxidant agents to be used in the pharmaceutical industry.
Food distance and its effect on nutrient balancing in a mobile insect herbivore

Abstract We investigated how the distance between foods of differing nutrient content affects macronutrient (protein and digestible carbohydrate) regulation and the patterns of food acquisition, movement and feeding activity in fifth-instar nymphs of Locusta migratoria (L.) (Orthoptera: Acrididae). We placed individual insects into one of three differently sized circular arenas (20, 40 or 80 cm diameter) that contained four dishes of chemically defined synthetic food. One of these dishes contained high-protein, low-carbohydrate food (P), and the other three dishes contained low-protein, high-carbohydrate food (C). Alone, these foods are nutritionally unbalanced, but together they are complementary. Regardless of arena size, locusts regulated their protein–carbohydrate intake to similar points, and in all three arenas they ate preferentially from the dish containing the P-food. We also recorded the patterns of foraging behaviour for 12 h on days 1 and 4 of the experiment, which allowed us to determine the effect of distance between foods and whether behaviour was modified with experience in the different arenas. Locusts' foraging behaviour in small arenas was similar on days 1 and 4, and the time they spent in different parts of the arena did not differ from that predicted by the simplest random probability model. In contrast, the foraging behaviour of locusts in the medium and large arenas changed between days 1 and 4, including spending more time in the area of the arena containing the P-food and visiting fewer of the C-food dishes. We discuss how distance between foods influences foraging strategies, and the possible role of learning in its development. Copyright 2003 Published by Elsevier Ltd on behalf of The Association for the Study of Animal Behaviour.
Panitumumab in combination with modified docetaxel/cisplatin/5-fluorouracil as first-line treatment in gastric and gastroesophageal junction adenocarcinomas: a multicenter phase II study by the Hellenic Oncology Research Group

Background A phase I/II study to define the maximum tolerated dose (MTD) of biweekly docetaxel/cisplatin/5-fluorouracil (DCF) plus panitumumab (P), its efficacy, and tolerability as first-line treatment in advanced gastroesophageal cancer. Methods In phase I part, patients with unresectable locally advanced or metastatic adenocarcinomas of the stomach or the gastroesophageal junction received cisplatin (40 mg/m2 on day 1), leucovorin (400 mg/m2 on day 1), 5-fluorouracil (400 mg/m2 bolus on day 1), 5-fluorouracil (1000 mg/m2/daycontinuous infusion on days 1-2), and escalated doses of docetaxel (on day 1) plus P (6 mg/kg on day 1) every 2 weeks. In phase II part, patients were treated with DCF/P at the MTD and the primary endpoint was response rate. The expected response rate was set at >40%. Results The MTD for docetaxel in the mDCF/P was defined at 40 mg/m2 and a total of 40 evaluable patients were enrolled in phase II study. One (2.5%) complete and 13 (32.5%) partial responses (overall response rate: 35%), as well as 16 (40%) disease stabilizations were documented. The median progression-free survival was 6.9 months (95% confidence interval [CI] 3.5-10.3) and the median overall survival was 11.3 months (95%CI 7.7-14.8). Grade 3-4 neutropenia occurred in 10 patients (25%) and febrile neutropenia in 2 (5%). Allergic reactions (grade 1-4) occurred in 9 patients (22.5%). There was 1 treatment-related death. Conclusions mDCF/P combination was feasible, though associated with a poor toxicity profile. However, the study failed to meet its primary endpoint and was terminated prematurely due to futility.
Aberrant Activation of NF-κB Signalling in Aggressive Lymphoid Malignancies

Lymphoid malignancies frequently harbor genetic mutations leading to aberrant activation of nuclear factor-κB (NF-κB) signaling; in normal cells, this pathway has important roles in the control of cell growth, survival, stress responses, and inflammation. Malignancies with mutations in NF-κB pathway components can derive from all cell stages of mature B-cell development; however, aberrant NF-κB activity is particularly prevalent in aggressive subtypes of non-Hodgkin lymphoma and myeloma. NF-κB activation is mediated by two separate pathways, the canonical and alternative pathway, and five downstream transcription factor subunits. Recent findings implicate a predominant role for distinct NF-κB pathways and subunits in certain lymphoma subtypes and myeloma; findings which are complemented by the realization that individual NF-κB subunits can have unique, non-redundant biological roles in the putative tumor precursor cells, including activated B cells, germinal center B cells and plasma cells. The knowledge gained from these studies may be exploited for the development of therapeutic strategies to inhibit aberrant NF-κB activity at the level of the transcription-factor subunits and their target genes, as global inhibition of the pathway is toxic. Here, we provide an overview on the role of aberrant NF-κB activation in aggressive lymphoid malignancies and discuss the potential importance of individual NF-κB subunits in the pathogenesis of tumor subtypes.
Fasting affects intake behaviour and diet preference of grazing sheep

Abstract Abstract. In separate experiments, the effects of fasting on the intake behaviour and diet preference of sheep, Ovis aries, were explored by comparing animals that had been fasted for 24 h with control animals that had not been fasted. Intake and its components (prehension bite rate and bite mass) were compared in animals grazing from monocultures of perennial ryegrass, Lolium perenne , and white clover, Trifolium repens. The effects of fasting on diet preference were studied by releasing flocks of three sheep onto 0·25 ha plots of land, which were either 20% clover (and 80% grass) or 80% clover (and 20% grass), by area. Within each of the 12 flocks, the diet preference of one focal animal was recorded on the first and third days following fasting. Fasting led to a significant increase in the intake rate (42% higher for clover, 72% higher for grass), achieved largely by an increase in bite mass. Both fasted and non-fasted animals had a significantly greater intake rate when eating clover than when eating grass, but fasted animals spent a significantly lower proportion of their time grazing clover (82% versus 92% for non-fasted animals). These results show that fasting not only increased the animals' drive to eat (grazing time and intake rate) but also altered the diet composition. This study lends support to the use of state-dependent modelling for grazing behaviour and suggests that researchers should be wary of studies of diet selection or preference in which experimental animals were fasted.
An experimental investigation into status-dependent male dimorphism in the European earwig, Forficula auricularia


Discrete alternative reproductive phenotypes are probably often due to individuals adopting alternative tactics with unequal fitnesses in conditional strategies with status-dependent selection. One tactic is believed to be favoured below a status switch point and another tactic above it, owing to different fitness functions of the tactics. Males of the European earwig are dimorphic. Macrolabic males are large (high status) and have long forceps, and brachylabic males are small (low status) with short forceps. I tested whether fitness functions, measured as mating success, of the two morphs differed with regard to forceps length and body weight. Macrolabic males with longer forceps than a competing male had higher mating success but brachylabic males benefited by being heavier than their competitor. Thus, different selection regimes were acting on the two morphs, suggesting that their fitness functions differed in relation to status. These observations and those of previous studies, showing that morph expression is environmentally determined and is associated with body size and that the morphs have unequal fitness, provide support for the hypothesis that male dimorphism in this species is a conditional strategy that has evolved under status-dependent selection. The differential investment in forceps growth that characterizes the morphs was manifested in a steeper allometric relation between forceps length and body size in macrolabic than brachylabic males. Behavioural observations showed that males of both morphs engaged in direct contests for females. Copyright 2003 The Association for the Study of Animal Behaviour. Published by Elsevier Science Ltd. All rights reserved.
3D Integrated Circuit Cooling with Microfluidics

Using microfluidic cooling to achieve thermal management of three-dimensional integrated circuits (ICs) is recognized as a promising method of extending Moore law progression in electronic components and systems. Since the U.S. Defense Advanced Research Projects Agency launched Intra/Inter Chip Enhanced Cooling thermal packaging program, the method of using microfluidic cooling in 3D ICs has been under continuous development. This paper presents an analysis of all publications available about the microfluidic cooling technologies used in 3D IC thermal management, and summarized these research works into six categories: cooling structure design, co-design issues, through silicon via (TSV) influence, specific chip applications, thermal models, and non-uniform heating and hotspots. The details of these research works are given, future works are suggested.
Preliminary Evidence of Sex Differences in Cortical Thickness Following Acute Mild Traumatic Brain Injury

The main objective of this study was to evaluate sex differences in cortical thickness after acute mild traumatic brain injury (mTBI) and its associations with clinical outcomes. Thirty-two patients with mTBI at acute phase (2.4 ± 1.3 days post-injury) and 30 healthy controls were enrolled. All the participants underwent comprehensive neurocognitive assessments and MRI to assess cortical thickness. Significant sex differences were determined by using variance analysis of factorial design. Relations between the cortical thickness and clinical assessments were measured with the Spearman Correlation. Results revealed that patients with mTBI had significantly reduced cortical thickness in the left entorhinal cortex while increased cortical thickness in the left precuneus cortex and right lateral occipital cortex, compared with healthy controls. The interaction effect of the group × sex on cortical thickness was significant. Female patients had significant thicker cortical thickness in the left caudal anterior cingulate cortex (ACC) than male patients and had higher scores on Posttraumatic stress disorder Checklist—Civilian Version (PCL-C). Spearman correlational analysis showed a significantly positive correlations between the cortical thickness of the left caudal ACC and PCL-C ratings in female patients. Sex differences in cortical thickness support its potential as a neuroimaging phenotype for investigating the differences in clinical profiles of mild TBI between women and men.
Public Understanding and Awareness of Isotretinoin Use and Safety in Al Ahsa, Eastern Saudi Arabia

Background Acne vulgaris, a chronic inflammatory disease, is among the most common dermatologic conditions worldwide. In Saudi Arabia, Isotretinoin is commonly used to treat mild acne even without prescription. Objective To explore the practice and knowledge of community in Saudi Arabia regarding dispensing, counseling practices, and safety of isotretinoin-containing products. Methods A cross-sectional survey, using a self-administered questionnaire, was conducted in 3 sections: demographics, self-medication attitude (in the form of self Isotretinoin use), and identifying the side effects associated with the use of isotretinoin. Results A total of 1069 participated in the study. Around half of the participants (44.2%) used isotretinoin with only mild acne as their first choice, which is contrary to the recommended guidelines. Virtually one-fifth of the participants did not examine the lipid profile, liver enzymes, and blood glucose level before isotretinoin use. Not many participants identified lipid (58.7%) and liver (44.1%) depression (53.3%), inflammatory bowel disease (75.9%), osteoporosis (60.3%), and sunburns (36.3%) as risks allied with isotretinoin use. Most participants (88.9%) appropriately recognized teratogenicity as the greatest hazard concomitant with the use of isotretinoin. Nevertheless, 20% of the women did not know that they must cease the drug at least 6 months before pregnancy. Conclusion This study shows that community residents are not satisfactorily aware of the proper use and jeopardies of isotretinoin. Therefore, greater consideration ought to be dedicated to augment the safe use of isotretinoin. We recommend the implementation of tools to enhance the safe use of isotretinoin and the imposition of more effective regulations to limit nonprescribed isotretinoin dispensing in Saudi Arabia.
A Closed System for Pico-Liter Order Substance Transport from a Giant Liposome to a Cell

In single cell analysis, transport of foreign substances into a cell is an important technique. In particular, for accurate analysis, a method to transport a small amount (pico-liter order) of substance into the cell without leakage while retaining the cell shape is essential. Because the fusion of the cell and the giant liposome is a closed system to the outside, it may be possible to transport a precise, small amount of substances into the cell. Additionally, there is no possibility that a leaked substance would affect other systems. To develop the liposome-cell transportation system, knowledge about the behavior of substances in the liposome and the cell is important. However, only a few studies have observed the substance transport between a liposome and a cell. Here, we report observation of small amount of substance transport into a single C2C12 cell by using a giant liposome. Substance transport occurred by electrofusion between the cell and the giant liposome containing the substance, which is a closed system. First, to observe the electrofusion and substance transport from the moment of voltage application, we fabricated a microfluidic device equipped with electrodes. We introduced suspensions of cells and liposomes into the microfluidic device and applied alternating current (AC) and direct current (DC) voltages for electrofusion. We observed a small amount (22.4 ± 0.1%, 10.3 ± 0.4% and 9.1 ± 0.1%) of fluorescent substance (Calcein) contained in the liposomes was transported into the cell without leakage outside the cell, and we obtained the diffusion coefficient of Calcein in the cell as 137 ± 18 μm2/s. We anticipate that this system and the knowledge acquired will contribute to future realization of more accurate single cell analysis in a wide range of fields.
Aligning Very Small Parallel Corpora Using Cross-Lingual Word Embeddings and a Monogamy Objective

Count-based word alignment methods, such as the IBM models or fast-align, struggle on very small parallel corpora. We therefore present an alternative approach based on cross-lingual word embeddings (CLWEs), which are trained on purely monolingual data. Our main contribution is an unsupervised objective to adapt CLWEs to parallel corpora. In experiments on between 25 and 500 sentences, our method outperforms fast-align. We also show that our fine-tuning objective consistently improves a CLWE-only baseline.
Teachers’ Values as Predictors of Classroom Management Styles: A Relative Weight Analysis

Teachers potentially are important agents of socialization for their students and teachers’ values drive their goals and desirable behaviors. Teachers’ goals and behaviors are also primary influences on students’ achievement motivation and learning. This study – which referred to Schwartz’s Universal Theory of Human Values and involved 157 Italian high school teachers – focused on the relation between teachers’ personal values (i.e., the values teachers feel to be important for themselves) and socialization values (i.e., the values they would like their students to endorse) on the one hand, and their classroom management styles (authoritarian, authoritative, and permissive styles) on the other. Results showed the importance of values in determining the teaching styles, greater in the case of authoritative and authoritarian styles than of permissive style. Implications of these results for teachers’ practices and further expansions of the study are discussed.
Inhibition of Connexin 43 Hemichannels Alleviates Cerebral Ischemia/Reperfusion Injury via the TLR4 Signaling Pathway

Connexin 43 (Cx43) widely exists in all components of the neurovascular unit (NVU) and is a constituent of gap junctions and hemichannels. In physiological states, gap junctions are open for regular intercellular communication, and the hemichannels present low open probability in astrocytes. After cerebral ischemia, a large number of hemichannels are unusually opened, leading to cell swelling and even death. Most known hemichannel blockers also inhibit gap junctions and sequentially obstruct normal electrical cell-cell communication. In this study, we tested the hypothesis that Gap19, a selective Cx43-hemichannel inhibitor, exhibited neuroprotective effects on cerebral ischemia/reperfusion (I/R). An obvious improvement in neurological scores and infarct volume reduction were observed in Gap19-treated mice after brain ischemia induced by middle cerebral artery occlusion (MCAO). Gap19 treatment attenuated white matter damage. Moreover, Gap19 treatment suppressed the expression of Cx43 and Toll-like receptor 4 (TLR4) pathway-relevant proteins and prevented the overexpression of tumour necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). To further explore downstream signaling, we established an in vitro model–oxygen glucose deprivation (OGD) to simulate ischemic conditions. Immunofluorescence staining showed that Cx43 co-existed with TLR4 in astrocytes. The hemichannel activity was increased after OGD and Gap19 could inhibit this effect on astrocytes. Gap19 substantially improved relative cell vitality and decreased the expression of Cx43, TLR4 and inflammatory cytokines in vitro. In addition, in the lipopolysaccharide (LPS) stimulation OGD model, Gap19 also exhibited a protective effect via inhibiting TLR4 pathway activation. In summary, our results showed that Gap19 exerted a neuroprotective effect after stroke via inhibition of the TLR4-mediated signaling pathway.
KHALİFA UNİVERSİTY OF SCİENCE, TECHNOLOGY AND RESEARCH (KUSTAR) STUDENTS’ ATTİTUDES TOWARDS MATHEMATİCS İN THE LİGHT OF VARİABLES SUCH AS GENDER, NATİONALİTY, MATHEMATİCS SCORES AND THE COURSE THEY ARE ATTENDİNG

This study was aimed at identifying the attitudes of the students of Khalifa University towards mathematics . The sample of this study consisted of 88(out of 216) students distributed evenly according to gender. 56.9% of the sample were Emiraties and 53.1% were expatriates. The Attitude Towards Mathematics Inventory (ATMI) was implemented in collecting the data. The results of this study indicated that there were slight statistically significant differences QUOTE r=0304) between students’ attitudes towards mathematics and mathematics achievement scores, age, the course they are attending, students’ high school type, gender and their academic level. Additionally, the results indicated that there were statistically significant differences between self-confidence QUOTE F 1,78 =9.699 , enjoyment QUOTE F 1,82 =15.285 and value QUOTE F 1,83 =6.419 with QUOTE p=0.013 and students’ nationalities. Expatriates students showed higher positive attitudes towards mathematics than the Emirati students. Also, the results showed that there was a slight statistical relationship between enjoyment and students’ academic level. Finally, this study revealed that 62.67% of the sample have self-confidence in dealing with mathematics, 84.4% felt that mathematics has a great value to them, and 75.49% showed enjoyment in dealing with mathematics.
A Critical Analysis of Transverse Dispersivity Field Data

Transverse dispersion, or tracer spreading orthogonal to the mean flow direction, which is relevant e.g, for quantifying bio‐degradation of contaminant plumes or mixing of reactive solutes, has been studied in the literature less than the longitudinal one. Inferring transverse dispersion coefficients from field experiments is a difficult and error‐prone task, requiring a spatial resolution of solute plumes which is not easily achievable in applications. In absence of field data, it is a questionable common practice to set transverse dispersivities as a fraction of the longitudinal one, with the ratio 1/10 being the most prevalent. We collected estimates of field‐scale transverse dispersivities from existing publications and explored possible scale relationships as guidance criteria for applications. Our investigation showed that a large number of estimates available in the literature are of low reliability and should be discarded from further analysis. The remaining reliable estimates are formation‐specific, span three orders of magnitude and do not show any clear scale‐dependence on the plume traveled distance. The ratios with the longitudinal dispersivity are also site specific and vary widely. The reliability of transverse dispersivities depends significantly on the type of field experiment and method of data analysis. In applications where transverse dispersion plays a significant role, inference of transverse dispersivities should be part of site characterization with the transverse dispersivity estimated as an independent parameter rather than related heuristically to longitudinal dispersivity.