Miracle-dz/UniFAR-FTUs huggingface dataset:
Every Cloud Has a Silver Lining: Positive Effects of Deviant Coworkers

ABSTRACT Drawing on the labeling perspective of deviance, we investigate employee reactions to coworkers perceived as deviants. We look at two positive effects for employees in the presence of a deviant coworker. First, in comparison to a deviant individual, other employees can draw more positive conclusions about themselves; and second, a deviant can be informative about organizational norms, thereby improving employee role clarity. We also examine individual and situational moderators. For the purpose of the study, we developed a measure of the presence of a deviant. The hypothesized relationships were tested in two large samples using multiple regression analyses. The results revealed that in the presence of a deviant coworker, employees reported enhanced self-evaluation. The presence of a deviant coworker was associated with better role clarity only for employees with more interdependent jobs. We also discuss practical implications of the findings and future research directions.
Diffusion and solubility factors in pulmonary insert gas exchanges.

Comparisons have been made in anesthetized dogs of the relative recoveries in arterial blood of pairs of inert gases injected as solutions into the right heart or as gas mixtures into the trachea. The gases differed in their diffusion coefficients or in their solubility. The pairs used were: tritium and Kr 85 ; ethylene-C 14 and Xe 133 . The ratios of the recoveries of the gases approached the ratios of their solubilities and not the ratios of their diffusion coefficients. The site of injection had no significant effect. The concentration-time curves remain proportional during the first passage through the lungs. Diffusion equilibrium is attained within the time of passage of blood through the alveolar capillary. There is no evidence of a diffusion limitation on the exchange of gases with diffusion coefficients as small as that of xenon. Solubility is the limiting factor. Submitted on April 12, 1961
Novel Aspects in the Management of Cholestatic Liver Diseases

Background: There is a great need for risk stratification in patients with chronic cholestatic diseases in order to allow for more personalized care and adapted management as well as for well-designed therapeutic trials. Novel tools for monitoring primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) patients have been recently proposed. In addition, major insight has been gained into bile acid (BA) physiology during the last decade including the role of BAs as metabolic modulators and the gut-liver axis. As a consequence, alongside drugs targeting immune response or fibrotic processes, a number of novel anti-cholestatic agents have undergone pre-clinical and clinical evaluation and have shown promising results although none has been approved yet. Key Messages: Biochemical non-response to ursodeoxycholic acid (UDCA) (mainly defined by bilirubin and alkaline phosphatase levels at 1 year) is a strong prognostic factor in PBC whereas present biochemical surrogates are far from robust in PSC. By contrast, liver stiffness measurement by vibration-controlled transient elastography (VCTE) is a very promising tool in both PBC and PSC. Novel therapeutic approaches include (i) agonists of nuclear receptors, especially farnesoid X receptor (FXR), pregnane X receptor (PXR), glucocorticoid receptor (GR) and peroxisome proliferator-activated receptor α (PPARα) that are transcriptional modifiers of bile formation; (ii) agonists of TGR5, a BA membrane receptor expressed in various tissues; (iii) inhibitors of the ileal apical sodium BA transporter; (iv) derivatives of the FXR-induced fibroblast growth factor 19 from the ileum that suppresses hepatic BA synthesis and (v) norUDCA, a side chain shortened UDCA derivative with specific physicochemical and therapeutic properties. The most advanced clinical evaluation (PBC patients) relates to agonists for PPARα, FXR and GR/PXR most often in combination with UDCA, namely fibrates, obeticholic acid (OCA) and budesonide, respectively. Existing results look promising even though some side effects are worrisome such as pruritus in OCA-treated patients. Results of large well-designed studies are eagerly awaited. Conclusions: Major advances in the management of cholestatic liver diseases are in progress and promising times for these patients seem likely in the near future.
Sustained benefit at 10-14 years follow-up after thrombolytic therapy in myocardial infarction.

AIMS To investigate whether the benefit of thrombolytic therapy was sustained beyond the first decade. We report the 10-14 year outcome of 533 patients who were randomized to treatment with intracoronary streptokinase or to conventional therapy during the years 1980-1985. METHODS AND RESULTS Details of survival and cardiac events were obtained from the civil registry, from medical records or from the patient's physician. At follow-up, 158 patients (59%) of the 269 patients allocated to thrombolytic treatment and only 129 patients (49%) of the 264 conventionally treated patients were alive. The cumulative 1-, 5- and 10-year survival rates were 91%, 81% and 69% in patients treated with streptokinase and 84%, 71% and 59% in the control group, respectively (P=0.02). Reinfarction during 10-years of follow-up was more frequent after thrombolytic therapy, particularly during the first year. Coronary bypass surgery and coronary angioplasty were more frequently performed after thrombolytic therapy. At 10 years approximately 30% of the patients were free from subsequent cardiac events. Independent determinants of mortality were elderly age, indicators of impaired residual left ventricular function, multivessel disease and an inability to perform an exercise test at the time of hospital discharge. CONCLUSION Improved survival after thrombolytic therapy is maintained beyond the first decade. Age, left ventricular function, multivessel disease and an inability to perform an exercise test were independent predictors for long-term mortality, as they are predictors for early mortality.
Nonreciprocity Compensation Combined With Turbo Codes for Secret Key Generation in Vehicular Ad Hoc Social IoT Networks

The physical attributes of the dynamic vehicle-to-vehicle propagation channel can be utilized for the generation of highly random and symmetric cryptographic keys. However, in a physical-layer key agreement scheme, nonreciprocity due to inherent channel noise and hardware impairments can propagate bit disagreements. This has to be addressed prior to the symmetric key generation which is inherently important in Social Internet of Things networks, including in adversarial settings (e.g., battlefields). In this paper, we parametrically incorporate temporal variability attributes, such as 3-D scattering and scatterers’ mobility. Accordingly, this is the first work to incorporate such features into the key generation process by combining nonreciprocity compensation with turbo codes (TCs). Preliminary results indicate a significant improvement when using TCs in bit mismatch rate and key generation rate in comparison to sample indexing techniques.
How can we detect anomalies from subsampled audio signals?

We aim to reduce the cost of sound monitoring for maintain machinery by reducing the sampling rate, i.e., sub-Nyquist sampling. Monitoring based on sub-Nyquist sampling requires two sub-systems: a sub-system on-site for sampling machinery sounds at a low rate and a sub-system off-site for detecting anomalies from the subsampled signal. This paper proposes a method for achieving both subsystems. First, the proposed method uses non-uniform sampling to encode higher than the Nyquist frequency. Second, the method applies a long short-term memory-(LSTM)-based autoencoder network for detecting anomalies. The novelty of the proposed network is that the subsampled time-domain signal is demultiplexed and received as input in an end-to-end manner, enabling anomaly detection from the subsampled signal. Experimental results indicate that our method is suitable for anomaly detection from the subsampled signal.
Interval exercise alters feed intake as well as leptin and ghrelin concentrations in standardbred mares.

REASONS FOR PERFORMING STUDY Horses in training tend to become inappetant; however, the mechanism responsible for this training-induced inappetance is not known. HYPOTHESIS Training and/or ulcers alter the feed intake (FI) and hormonal and/or biochemical (active ghrelin, leptin, glucose, insulin and cortisol) responses to acute high intensity exercise. METHODS Eight Standardbred mares underwent 3 interval exercise tests (IET) and 3 parallel control tests (CON) before (IET1) and after 8 weeks of training (IET2) and after treatment for gastric ulcers (IET3). Plasma samples were taken before (0 min), during (last 10 sec of velocities eliciting 40, 100 and 20% VO2max), and after (30 min, 60 min, 24 h) exercise (EX) or CON tests for RIA and colorimetric measurement of the concentrations of the above parameters. Samples were also collected before and after feeding. Horses were trained at a work intensity of 70% HRmax for 30 min/day, 5 days per week with FI measured daily. RESULTS There were no changes (P>0.05) in any variable during the parallel control trials. However, there was a mismatch between FI and digestible energy (DE) requirements (P<0.05) with EX horses not meeting their DE requirements during the post training IETs. During all IETs, ghrelin, glucose and cortisol increased (P<0.05) during EX. Leptin only increased (P<0.05) during EX in the post training IETs. Insulin remained low during EX, but increased (P<0.05) post EX. CONCLUSION High intensity exercise appeared to be associated with decreases in FI and alterations of leptin and ghrelin. POTENTIAL RELEVANCE More research is needed to determine if there is a relationship between alterations of these hormones and changes in FI in horses that lose weight while in training.
CT Scans in Schizophrenia

The term ‘dementia praecox’ was used by Kraepelin to emphasise the tendency towards deterioration to a state of impairment resembling a dementia. Early studies looked for structural brain lesions post mortem, and later using pneumoencephalography; there were positive findings (Haug, 1962), but they were not always replicated (Storey, 1966). The risks and limitations of pneumoencephalography gradually led to its being abandoned. However, studies showing minor neurological abnormalities (Rochford et al, 1970) and cognitive impairment (Malec, 1978) continued to suggest an organic component to schizophrenia.
[Quality of life and sexuality of women treated for breast cancer].

PURPOSE To evaluate the quality of life and sexuality features of women with breast cancer, according to the type of surgery they underwent and their sociodemographic characteristics. METHODS Transversal study with 110 women treated for breast cancer, for at least one year in the Centro de Atenção Integral à Saúde da Mulher of UNICAMP. The quality of life was assessed by the WHOQOL-bref questionnaire, and the issues on sexuality, by a specific questionnaire in which Cronbach's Alpha coefficient was used to validate the concordance of responses (alpha=0.72) and the technique of factor analysis, with the criterion of self value and variance maximum rotation, resulting in two components: intrinsic or intimacy ( how the woman sees herself sexually) and extrinsic or attractiveness (how the woman believes the others see her sexually). Sociodemographic variables have been assessed according to the WHO questionnaire, and the sexuality components, through the Kruskal-Wallis followed by the Mann-Whitney's test and Spearman correlation test. RESULTS Age, schooling, type of surgery and lapse of time from the surgery did not influence the quality of life concerning physical, environmental, and psychological aspects, as well as the social relationships. Women with a stable marital relationship got higher scores in the psychological area (p=0.04) and in the area of social relationships (p=0.02). Higher socioeconomic level influenced the quality of life concerning physical appearance (p=0.01) and environment (p=0.002). Regarding the sexuality, age had influence in the extrinsic component (p=0.0158). Women with a stable marital relationship had higher scores of quality of life in both components of sexuality. Higher schooling influenced in a positive way the intrinsic factor. Women submitted to quadrantectomy or mastectomy with immediate breast reconstruction showed higher scores relating to attractiveness in comparison to mastectomized women without reconstruction. CONCLUSIONS Better socioeconomic level and better schooling, stable marital relationship and surgery with breast conservation are linked to better rates of quality of life, including sexuality.
Targeting of N‐CoR and histone deacetylase 3 by the oncoprotein v‐ErbA yields a chromatin infrastructure‐dependent transcriptional repression pathway

Transcriptional repression by nuclear hormone receptors is thought to result from a unison of targeting chromatin modification and disabling the basal transcriptional machinery. We used Xenopus oocytes to compare silencing effected by the thyroid hormone receptor (TR) and its mutated version, the oncoprotein v‐ErbA, on partly and fully chromatinized TR‐responsive templates in vivo. Repression by v‐ErbA was not as efficient as that mediated by TR, was significantly more sensitive to histone deacetylase (HDAC) inhibitor treatment and, unlike TR, v‐ErbA required mature chromatin to effect repression. We find that both v‐ErbA and TR can recruit the corepressor N‐CoR, but, in contrast to existing models, show a concomitant enrichment for HDAC3 that occurs without an association with Sin3, HDAC1/RPD3, Mi‐2 or HDAC5. We propose a requirement for chromatin infrastructure in N‐CoR/HDAC3‐effected repression and suggest that the inability of v‐ErbA to silence on partly chromatinized templates may stem from its impaired capacity to interfere with basal transcriptional machinery function. In support of this notion, we find v‐ErbA to be less competent than TR for binding to TFIIB in vitro and in vivo.
Reduced vitamin E antioxidant capacity in sickle cell disease is related to transfusion status but not to sickle crisis

In homozygous sickle cell disease (SCD), decreased serum Vitamin E is present. Excessive transfusions may lead to iron overload. We hypothesised a relationship between the two and found that Vitamin E type antioxidant capacity was significantly lower in 30 SCD patients than in 30 age‐ and sex‐matched controls (P < 0.001). Antioxidant capacity was lower in 10 transfused patients compared with 20 non‐transfused patients (P < 0.001). Transfusional iron overload in SCD may increase the potential for oxidative damage, and low antioxidant capacity may compound this effect. Am. J. Hematol. 69: 144–146, 2002. © 2002 Wiley‐Liss, Inc.
STANDARDIZATION OR ADAPTATION IN COSMETICS WEBSITES MARKETING ? AN EMPIRICAL STUDY.

The websites marketing is becoming an important tool both for multinationals and SMEs, in their effort to internationalizing their business. This study focuses on the international opportunities that are present within the European markets. The paper aims at identifying the degree of websites marketing standardization vs. adaptation, as a marketing tool for cosmetic products. Moreover, the study examines in a comparative manner the standardization strategy of multinationals and small and medium enterprises (SMEs), leaders in European markets, for different cosmetic cathegories. The evaluation of online advertising standardization is based on the modified Model for Testing Advertising Standardization, developed by Whitelock and Chung. The web sites degree of localizations are analyzed based upon 98 criteria, as resulted from an adapted methodology of ProfNet Institut fur Internet Marketing, Munster (Germany). The sample includes the 101 leaders from European markets. The research outcomes reflect a standardized websites marketing policy for SMEs and localized for multinationals. Also, for perfumes, dental care products and toiletry, European cosmetic leaders implement standardized websites marketing policies and balanced for the other cosmetics categories. The hypothesis concerning a strong correlation between standardization and handling dimension was supported.
Calibration of electrostatic discharge generators and results of an international comparison

Electrostatic discharge generators are widely used for testing various equipment with any kind of man-machine interface. The calibration of ESD-generators causes a number of problems such as: the target and the cable set which have a frequency dependent transfer characteristic, the measurement system of large bandwidth etc. A procedure is presented that enables the characterisation of the measurement system and a method is described which allows the correction of the data for the transmission characteristics. Results of an international comparison of ESD-generator calibrations are presented.
Self‐association of EPEC intimin mediated by the β‐barrel‐containing anchor domain: a role in clustering of the Tir receptor

Outer membrane intimin directs attachment of enteropathogenic Escherichia coli (EPEC) via its Tir receptor in mammalian target cell membranes. Phosphorylation of Tir triggers local actin polymerization and the formation of ‘pedestal‐like’ pseudopods. We demonstrate that the intimin protein contains three domains, a flexible N‐terminus (residues 40–188), a central membrane‐integrated β‐barrel (189–549), and a tightly folded Tir‐binding domain (550–939). Intimin was shown by electron microscopy to form ring‐like structures with a ∼7 nm external diameter and an electron dense core, and to form channels of 50picoSiemens conductance in planar lipid bilayers. Gel filtration, multiangle light scattering and cross‐linking showed that this central β‐barrel membrane‐anchoring domain directs intimin dimerization. Isothermal titration calorimetry revealed a high affinity, single‐binding site interaction of 2 : 1 stoichiometry between dimeric intimin and Tir, and modelling suggests that this interaction determines a reticular array‐like superstructure underlying receptor clustering. In support of this model, actin rearrangement induced in Tir‐primed cultured cells by intimin‐containing proteoliposomes was dependent on the concentration of both intimin and Tir, and co‐localized with clustered phosphorylated Tir.
Total-dose effects caused by high-energy neutrons and γ-rays in Multiple-Gate FETs

This work investigates the effects of high-energy neutrons and γ-rays on Multiple-Gate FETs with different geometries (notably gate lengths down to 50 nm). The impact of radiation on device behavior is addressed through the variation of parameters such as threshold voltage, subthreshold slope, transconductance maximum and DIBL. It is shown that degradations caused by γ-rays and high-energy neutrons with similar doses are largely similar. It is revealed that, contrarily to the generally-believed immunity to irradiation, very short-channel FinFETs can become extremely sensitive to the total dose effect. The possible reasons are discussed.
An in-depth study of a neutron star accreting at low Eddington rate: On the possibility of a truncated disc and an outflow

Due to observational challenges, our knowledge of low-level accretion flows around neutron stars is limited. We present NuSTAR, Swift and Chandra observations of the low-mass X-ray binary IGR J17062-6143, which has been persistently accreting at ? 0.1 per cent of the Eddington limit since 2006. Our simultaneous NuSTAR/Swift observations show that the 0.5–79 keV spectrum can be described by a combination of a power law with a photon index of ? 2, a blackbody with a temperature of kTbb ? 0.5 keV (presumably arising from the neutron star surface) and disc reflection. Modelling the reflection spectrum suggests that the inner accretion disc was located at Rin ? 100? GM/c2 (? 225 km) from the neutron star. The apparent truncation may be due to evaporation of the inner disc into a radiatively-inefficient accretion flow, or due to the pressure of the neutron star magnetic field. Our Chandra gratings data reveal possible narrow emission lines near 1 keV that can be modelled as reflection or collisionally ionized gas, and possible low-energy absorption features that could point to the presence of an outflow. We consider a scenario in which this neutron star has been able to sustain its low accretion rate through magnetic inhibition of the accretion flow, which gives some constraints on its magnetic field strength and spin period. In this configuration, IGR J17062-6143 could exhibit a strong radio jet as well as a (propeller-driven) wind-like outflow.
A hand-pose estimation for vision-based human interfaces

This paper proposes a novel method for a hand-pose estimation that can be used for vision-based human interfaces. The aim of this method is to estimate all joint angles. In this method, the hand regions are extracted from multiple images obtained by a multiviewpoint camera system. By integrating these multiviewpoint silhouette images, a hand pose is reconstructed as a "voxel model. " Then, all joint angles are estimated using a three-dimensional model fitting between the hand model and the voxel model. The following two experiments were performed: (1) an estimation of joint angles by the silhouette images from the hand-pose simulator and (2) hand-pose estimation using real hand images. The experimental results indicate the feasibility of the proposed algorithm for vision-based interfaces, although the algorithm requires faster implementation for real-time processing.
The effect of beta-propiolactone on the scrapie agent.

The transmissible agent of scrapie has not yet been characterized but it is commonly referred to as a virus (Andrewes & Pereira, 1967). However, on the basis of its resistance to acetylethyleneimine, Stamp et al. (1959) suggested that the agent might not contain nucleoprotein. Pattison (1965), reporting on the effect of formalin, expressed the opinion that the agent might not be a virus and now believes it to be, or to be associated with, a small basic protein (Pattison & Jones, 1967). In a study of the effect of ionizing and ultraviolet irradiation Alper, Haig & Clarke (1966) and Alper et al. (1967) suggested that the agent may lack nucleic acid. On the basis of these results and the inactivation of the scrapie agent with urea and phenol, Gibbons & Hunter (1967) have proposed a membrane hypothesis for its nature. Other workers (e.g. Adams & Caspary, 1967) still believe that the agent is essentially viral in character.
Sarcomatous Transformation in the Paget's Disease: A Case Report with aReview of Literature

The dreaded consequence of Paget’s disease is sarcomatous transformation, a neoplasm with poor prognosis. This report describes a 61-year-old patient who developed two sarcoma in Paget disease: the first on right distal humerus and the second on right clavicle. Time elapsed beetwen lesions was 5 years. Clavicle’s tumor should be considered as metastasis, but in our opinion, some interesting elements support theory of a second primitive tumor with a metachromous onset. We present clinical, radiological and pathological features of this case comparing it with a review of literature.