Miracle-dz/UniFAR-FTUs huggingface dataset:
Natriuretic Peptide System Gene Variants Are Associated with Ventricular Dysfunction after Coronary Artery Bypass Grafting

Background:Ventricular dysfunction (VnD) after primary coronary artery bypass grafting is associated with increased hospital stay and mortality. Natriuretic peptides have compensatory vasodilatory, natriuretic, and paracrine influences on myocardial failure and ischemia. The authors hypothesized that natriuretic peptide system gene variants independently predict risk of VnD after primary coronary artery bypass grafting. Methods:A total of 1,164 patients undergoing primary coronary artery bypass grafting with cardiopulmonary bypass at two institutions were prospectively enrolled. After prospectively defined exclusions, 697 patients of European descent (76 with VnD) were analyzed. VnD was defined as need for at least 2 new inotropes and/or new mechanical ventricular support after coronary artery bypass grafting. A total of 139 haplotype-tagging single nucleotide polymorphisms (SNPs) within 7 genes (NPPA, NPPB, NPPC, NPR1, NPR2, NPR3, CORIN) were genotyped. SNPs univariately associated with VnD were entered into logistic regression models adjusting for clinical covariates predictive of VnD. To control for multiple comparisons, permutation analyses were conducted for all SNP associations. Results:After adjusting for clinical covariates and multiple comparisons within each gene, seven NPPA/NPPB SNPs (rs632793, rs6668352, rs549596, rs198388, rs198389, rs6676300, rs1009592) were associated with decreased risk of postoperative VnD (additive model; odds ratios 0.44–0.55; P = 0.010–0.036) and four NPR3 SNPs (rs700923, rs16890196, rs765199, rs700926) were associated with increased risk of postoperative VnD (recessive model; odds ratios 3.89–4.28; P = 0.007–0.034). Conclusions:Genetic variation within the NPPA/NPPB and NPR3 genes is associated with risk of VnD after primary coronary artery bypass grafting. Knowledge of such genotypic predictors may result in better understanding of the molecular mechanisms underlying postoperative VnD.
p53 gene alterations and human papillomavirus type 16 infection in early stages of cervical carcinoma in Serbia.

PURPOSE The incidence rate (age-standardized) of cervical carcinoma in Serbia is the highest in Europe. p53 is mainly inactivated at protein level in carcinomas associated with human papillomavirus (HPV) infection, such as cervical carcinomas. These tumors show low rate of p53 mutations. It is not clear if p53 mutations confer additional impact on disease prognosis. The role of polymorphic variant at codon 72 of p53 gene on patient's prognosis is controversial. The aim of this study was to determine the frequency of p53 mutations and to assess polymorphic variants of codon 72 among cervical carcinoma patients. PATIENTS AND METHODS 53 patients, mainly FIGO stage I (n=50), with squamous cell carcinoma (n=49) were included. 30/32 (94%) patients who received adjuvant radiotherapy were followed-up (median 15 months, range 4-39). DNA was isolated by the salting out method from tumor tissue (n=53) and blood (42/53). p53 mutations were detected by PCR-SSCP (polymerase chain reaction - single-stranded conformational polymorphism) electrophoresis. Codon 72 polymorphism was assessed by the restriction fragment-length polymorphism method. RESULTS Six p53 mutations were detected in 5/53 (9%) patients with FIGO stage I squamous cell carcinoma (one patient had double mutations). 25/42 (60%) patients exhibited Arg/Arg genotype. HPV16 type was detected in 29/51 (57%) cervical carcinoma samples. Relapse of disease occurred in only 2 patients- both with Arg/Arg genotype and HPV16 positive. One of them exhibited p53 mutation. CONCLUSION Our results showed low incidence of p53 mutations and prevalence of Arg/Arg genotype polymorphic variant of codon 72 of p53 gene in early stages of cervical carcinoma.
Improving gamut mapping color constancy

The color constancy problem, that is, estimating the color of the scene illuminant from a set of image data recorded under an unknown light, is an important problem in computer vision and digital photography. The gamut mapping approach to color constancy is, to date, one of the most successful solutions to this problem. In this algorithm the set of mappings taking the image colors recorded under an unknown illuminant to the gamut of all colors observed under a standard illuminant is characterized. Then, at a second stage, a single mapping is selected from this feasible set. In the first version of this algorithm Forsyth (1990) mapped sensor values recorded under one illuminant to those recorded under a second, using a three-dimensional (3-D) diagonal matrix. However because the intensity of the scene illuminant cannot be recovered Finlayson (see IEEE Trans. Pattern Anal. Machine Intell. vol.18, no.10, p.1034-38, 1996) modified Forsyth's algorithm to work in a two-dimensional (2-D) chromaticity space and set out to recover only 2-D chromaticity mappings. While the chromaticity mapping overcomes the intensity problem it is not clear that something has not been lost in the process. The first result of this paper is to show that only intensity information is lost. Formally, we prove that the feasible set calculated by Forsyth's original algorithm, projected into 2-D, is the same as the feasible set calculated by the 2-D algorithm. Thus, there is no advantage in using the 3-D algorithm and we can use the simpler, 2-D version of the algorithm to characterize the set of feasible illuminants. Another problem with the chromaticity mapping is that it is perspective in nature and so chromaticities and chromaticity maps are perspectively distorted. Previous work demonstrated that the effects of perspective distortion were serious for the 2-D algorithm. Indeed, in order to select a sensible single mapping from the feasible set this set must first be mapped back up to 3-D. We extend this work to the case where a constraint on the possible color of the illuminant is factored into the gamut mapping algorithm. We show here that the illumination constraint can be enforced during selection without explicitly intersecting the two constraint sets. In the final part of this paper we reappraise the selection task. Gamut mapping returns the set of feasible illuminant maps. Our new algorithm is tested using real and synthetic images. The results of these tests show that the algorithm presented delivers excellent color constancy.
The effects of schistosomiasis on HIV/AIDS infection, progression and transmission

Purpose of reviewThe recent findings pertaining to the public health impact of schistosomiasis on the epidemiology of HIV/AIDS are summarized. Recent findingsBoth empiric data and mathematical models support the hypothesis that schistosome infections lead to increased susceptibility to infection with HIV-1, a more rapid progression to disease through more vigorous viral replication and immunosuppression, and a higher likelihood of transmitting the infection to others through both vertical and horizontal routes. Different species of schistosome infection vary in the magnitude of their effects on these mechanisms with Schistosoma haematobium playing a greater role for increased susceptibility and transmission because of its association with urogenital disease. SummarySchistosomiasis appears to be a cofactor in the spread and progression of HIV/AIDS in areas wherein both diseases are endemic; increased emphasis on treatment of schistosome infections in persons at risk of HIV/AIDS should be pursued.
Efficiency in the consumption of health services: concepts and research needs. Phase I: Review of concepts and literature and preliminary field design.

This paper is concerned with the definition and measurement of 4 kinds of inefficiency in the consumption of government health services in developing countries: 1) divergences between private and social preferences 2) distortionary pricing 3) prohibitive pricing and 4) outside influences on choice. After an introduction which considers Musgroves optimization model and problems with that model the second chapter provides a conceptual framework in the form of a geometric model pinpointing different kinds of inefficiency (including the 4 "consumer inefficiencies" mentioned above and 2 production side inefficiencies). The third chapter presents the results of a review of 97 publications organized into the topics of misinformation and utilization externalities of health services distortionary pricing prohibitive pricing responsiveness of utilization to price outside influences on choice and utilization and health status. In addition to providing many examples of the 4 kinds of consumption inefficiency the literature provides many estimates of the results which can be expected when prices or other policy variable are changed. Chapter 4 presents an algebraic simulation model for assessing consumption inefficiency with values assumed for the parameters. Simulations with the model are conducted in order to show the effects of policy changes on health status and on private utility. The policy instruments used include the prices of health services and health education programs which attempt to bring private preferences for health services into line with social preferences. In the last chapter a research proposal is made for estimating degrees of consumption inefficiency in the government health services of a specific country (the Gambia). This proposal allows the assessment of inefficiencies to be done by calculating the cost-effectiveness ratios. The results of this research could show how major gains in health status can be realized without increasing the total value of the resources employed.
Electrocardiographic changes and myocarditis in trichinellosis: a retrospective study of 154 patients

Abstract The frequencies of electrocardiographic (ECG) abnormalities and myocarditis were determined, retrospectively, among 154 cases of trichinellosis [101 males and 53 females, with a mean (S.D.) age of 35.60 (14.64) years] who were hospitalized at the University Hospital for Infectious Diseases in Zagreb, Croatia, over a 5-year period. Eighty-seven (56%) of the patients, most of them in the invasive phase of infection with Trichinella spiralis, were found to have abnormalities when examined by 12-lead, resting electrocardiography. The ECG disorder most frequently observed was a non-specific ventricular repolarization disturbance (with ST-T wave changes), followed by bundle-branch conduction disturbances, and sinus tachycardia. The other ECG disorders recorded, during various phases of the infection, were sinus bradycardia, right bundle-branch block, supraventricular and ventricular extrasystoles, low-voltage QRS complexes in standard limb leads, first-degree atrio-ventricular block, and atrial fibrillation. Eighteen (12%) of the patients were identified as cases of myocarditis (13 in the invasive phase and five in the convalescent) and two (1.3%) as cases of myopericarditis. One patient developed acute myocardial infarction 28 days after the onset of disease and died soon thereafter; an autopsy revealed multiple necroses and fibroses of the myocardium and thrombus of a coronary artery. Although ECG abnormalities appear to be a common feature of trichinellosis, especially during the invasive phase of the disease, they are rarely associated with a poor prognosis. A transient, non-specific, ventricular-repolarization disturbance is the abnormality most commonly observed.
Systemic and Regional Hemodynamics of Isoflurane and Sevoflurane in Rats

The authors studied the effects of sevoflurane and isoflurane on systemic hemodynamics and regional blood flow distribution (microsphere technique) in 15 rats during general anesthesia with intravenous chloralose and controlled ventilation. Inhaled anesthetics were applied to reduce mean arterial blood pressure (MAP) to 70 mm Hg (1.66 vol% sevoflurane and 0.96 vol% isoflurane) and 50 mm Hg (MAP 50; 3.95 vol% sevoflurane and 2.43 vol% isoflurane). Control recordings were obtained with intravenous chloralose only. At a MAP of 70 mm Hg, both anesthetics reduced heart rate, cardiac output, and systemic vascular resistance to a similar degree. Isoflurane decreased systemic vascular resistance markedly at a MAP of 50 mm Hg and thereby maintained cardiac output at higher levels than sevoflurane. The left ventricular rate-pressure product decreased comparably with both anesthetics. Cerebral blood flow increased dose-dependently with both inhaled anesthetics but to a greater degree with isoflurane. Total hepatic blood flow remained unchanged from control at a MAP of 70 mm Hg but decreased at a MAP of 50 mm Hg. This was due to reductions of hepatic arterial and portal venous tributaries. Renal blood flow was reduced with only the high concentrations of the anesthetics. Myocardial blood flow was reduced at all concentrations of volatile anesthetic; however, the decrease was less with isoflurane. This would indicate a more pronounced coronary vasodilation by isoflurane as the rate-pressure product, as a measure of the actual left ventricular oxygen demand, decreased by comparable degrees with both anesthetics. Our results indicate that sevoflurane and isoflurane (each approximately 0.7 MAC) have no dissimilar systemic and regional hemodynamic effects at a MAP of 70 mm Hg in this animal model. At higher concentrations (approximately 1.7 MAC), cerebral blood flow was more with isoflurane than with sevoflurane and was associated with a more pronounced vasodilation in the myocardium.
Costing Household Surveys for Monitoring Progress Toward Ending Extreme Poverty and Boosting Shared Prosperity

On October 15, 2015, World Bank Group President Jim Yong Kim announced the World Bank Group’s commitment to support the 78 poorest countries to implement a multi-topic household survey every three years between 2016 and 2030, for monitoring progress toward ending extreme poverty and boosting shared prosperity. This paper estimates the resource requirements to achieve the objectives of implementing 390 surveys across 78 International Development Association countries from 2016 to 2030, and providing direct technical assistance to the national statistical offices on all facets of survey design, implementation, and dissemination toward timely production of quality household survey data. The approach to the costing exercise is unique, as it makes use of detailed data on actual survey implementation and technical assistance costs from a group of countries, unlike previous attempts at costing household survey data gaps. The required total budget, in accordance with the survey design features recommended by the World Bank Household Survey Strategy, is estimated at US$945 million for the period of 2016-2030. Of this, US$692 million is projected to cover the survey implementation costs across 78 countries, and US$253 million is projected to cover the costs of direct technical assistance to be provided to the national statistical offices.
Multiwavelength observations revealing the evolution of the outburst of the black hole XTE J1118+480

We report multiwavelength observations of the soft X-ray transient XTE J1118+480, which we observed with UKIRT, Hubble Space Telescope (HST), RXTE, Extreme Ultraviolet Explorer (EUVE) and many other instruments and facilities. Adding radio (Ryle Telescope, VLA), submillimetre (JCMT) and X-ray (Chandra and SAX) data from the literature, we assembled the most complete spectral energy distribution (SED) of this source yet published. We followed the evolution of this source for 1 yr, including six observations performed during the outburst, and one observation at the end of the outburst. Because of the unusually high galactic latitude of XTE J1118+480, it suffers from very low extinction, and its SED is nearly complete, including extreme ultraviolet observations. XTE J1118+480 exhibits an unusually low low/hard state (estimated inner radius of 350R s ) and a strong non-thermal contribution in the radio to optical domain, which is likely to be due to synchrotron emission. We discuss the interstellar column density and show that it is low, between 0.80 and 1.30 x 10 2 0 cm - 2 . We analyse the evolution of the SED during the outburst, including the contributions from the companion star, the accretion disc, the outflow, and relating irradiation and variability of the source in different bands to the SED. We find no significant spectral variability during the outburst evolution, consistent with the presence of a steady outflow. An analysis of its outflow to accretion energy ratio suggests that the microquasar XTE J1118+480 is analogous to radio-quiet quasars. This, combined with the inverted spectrum from radio to optical, makes XTE J 1118+480 very similar to other microquasar sources, e.g. GRS 1915+105 and GX 339-4 in their low/hard state. We model the high-energy emission with a hot disc model, and discuss different accretion models for the broad-band spectrum of XTE J1118+480.
Making of A Successful Entrepreneur: Anatomy of an Entrepreneur Part II

Our earlier research paper, Anatomy of an Entrepreneur, provided some insights into the motivations of founders of high-growth companies, as well as their socio- economic, educational, and familial backgrounds. We found that technology entrepreneurs are most likely to come from middle-class backgrounds, to have parents who are less educated than they are, and to be married with children when they launch their first companies. Their primary motivations for launching a company are financial and emotional. They wanted to build wealth and had a business idea on which they wanted to capitalize. Many said they had always wanted their own companies some day.In this paper, we explore company founders’ opinions and observations about their own trajectory and what influenced the success or failure of their businesses. By understanding what entrepreneurs think and believe, we hope to provide more insights into how to better support entrepreneurs and create societal, political, and economic conditions that can more efficiently foster entrepreneurship.This research is based on a survey of 549 company founders in a variety of industries, including aerospace and defense, computer and electronics, health care, and services.
Evidence for early impairment of glucagon-like peptide 1-induced insulin secretion in human type 2 (non insulin-dependent) diabetes.

UNLABELLED To investigate a possible role of an enteroinsular axis involvement in the pathogenesis of type 2 diabetes, plasma glucagon-like peptide 1 (GLP-1) 7-36 amide response to nutrient ingestion was evaluated in type 2 diabetics affected by different degrees of beta-cell dysfunction. METHODS 14 patients on oral hypoglycaemic treatment (group A: HbA1C = 8.1 +/- 1.8 %) and 11 age-matched diabetic patients on diet only (group B: HbA1C = 6.4 +/- 0.9) participated in the study. 10 healthy volunteers were studied as controls. In the postabsorptive state, a mixed meal (700 kCal) was administered to all subjects, and blood samples were regularly collected up to 180' for plasma glucose, insulin, glucagon, and GLP-1 determination. RESULTS In the control group, the test meal induced a significant increase in plasma GLP-1 at 30' and 60' (p < 0.01); the peptide concentrations then returning toward basal levels. beta-cell function estimation by HOMA score confirmed a more advanced involvement in group A than in group B (p < 0.01). In contrast, the insulin resistance degree showed a similar result in the two groups (HOMA-R). In group A, first-phase postprandial insulin secretion (0 - 60') resulted, as expected, in being significantly reduced compared to healthy subjects (p < 0.001). In the same patients the mean fasting GLP-1 value was similar to controls, but the meal failed to increase plasma peptide levels, which even tended to decrease during the test (p < 0.01). In group B, food-mediated early insulin secretion was higher than in group A (p < 0.001), although significantly reduced when compared to controls (p < 0.01). Like group A, no GLP-1 response to food ingestion occurred in group B patients in spite of maintained basal peptide secretion. Whereas the test-meal did not significantly modify plasma glucagon levels in the control group, glucagon concentrations increased at 30' and 60' in both diabetic groups (p < 0.01). CONCLUSIONS 1) The functional integrity of GLP-1 cells results as being seriously impaired even in the condition of mild diabetes; 2) the early peptide failure could contribute to the development of beta-cell deterioration which characterizes overt type 2 diabetes.
A drug utilisation study investigating prescribed daily doses of hypolipidaemic agents.

OBJECTIVES To estimate average prescribed daily doses (PDDs) for selected hypolipidaemic agents available on the South African market. Comparison of the estimated PDDs with established DDDs (defined daily doses) and international dosage ranges. To investigate the age and gender of the users of the different hypolipidaemic drugs and drug groups. DESIGN Retrospective drug utilisation study using data from an organisation involved in the pre-certification of chronic medication. SETTING Doctors and patients in South Africa. Participants. A total of 2,336 patients of various medical aids who were using cholesterol-lowering medication on a chronic basis. OUTCOME MEASURES The PDDs, for the complete sample and for the age and gender groups. RESULTS More than 90% of all hyperlipidaemic patients in the study were treated with HMG CoA reductase inhibitors or fibrates. The average PDDs for the three most frequently prescribed lipid-lowering drugs were 414.4 mg for bezafibrate, 12.5 mg for pravastatin and 12.6 mg for simvastatin. The PDDs were on average lower than the established DDDs. Differences were observed in the pattern of lipid-lowering drug prescriptions for women and men. Male users were on average 3.9 years younger than female users. CONCLUSIONS The PDDs used in the patient population studied were within locally and internationally acceptable dosage ranges, but were generally lower than established DDDs for lipid-lowering drugs. Prescription differences exist between female and male patients and between age groups with regard to chronic medication. Further studies should be conducted to investigate hypolipidaemic drug prescribing in patients who are not on chronic medication.
Dietary folate is associated with p16INK4A methylation in head and neck squamous cell carcinoma

Inactivation of the p16INK4A (CDKN2A) gene in the Rb pathway is among the most common somatic alterations observed in tobacco‐related solid tumors, including head and neck squamous cell carcinoma (HNSCC). In addition, a low folate diet is an important risk factor for HNSCC. Decreased dietary folate in an animal model of hepatocellular carcinoma has been associated with the induction of epigenetic silencing of the p16INK4A gene. In an ongoing population‐based study of HNSCC, we sought to extend this observation to human disease testing the hypothesis that p16INK4A methylation is associated with decreased dietary folate. We also investigated the association of methylation silencing with functional polymorphisms in the folate metabolism enzyme methylene tetrahydrofolate reductase (MTHFR). In 169 HNSCCs, the odds ratio for p16INK4A methylation among those with low dietary folate intake was 2.3 (95% CI = 1.1–4.8) when compared with those with high folate intake. Furthermore, this increased risk for epigenetic silencing at p16INK4A was modified by the MTHFR alleles previously associated with diminished serum folate levels. Hence, in HNSCC low dietary intake of folate is associated with p16INK4A methylation, and this relationship is modified by the MTHFR genotype. Our data provides important evidence for a mechanism of action of folate deficiency in cancer. © 2006 Wiley‐Liss, Inc.