Miracle-dz/UniFAR-FTUs huggingface dataset:
An Evaluation of Reporting Guidelines and Clinical Trial Registry Requirements Among Plastic Surgery Journals

Background Ensuring that published studies are of the highest methodological quality is a critical step in plastic surgery's transition to a more evidence-based field. Reporting guidelines and reporting of clinical trial registration may serve as promising avenues of increasing the methodological quality in plastic surgery trials. Objective The objective of this study is to evaluate the rate at which plastic surgery journals require reporting guidelines, as well as the effect these policies have on adherence to reporting guidelines. Methods Using journal's “Instructions for Authors,” we conducted a cross-sectional survey to evaluate journal policies regarding adherence to reporting guidelines and trial registration. We also examined whether trials published in journals referencing Consolidated Standards of Reporting of Trials (CONSORT) had higher rates of compliance with publishing a CONSORT flow diagram and whether journals with trial registration policies were more likely to contain registered trials than journals without these requirements. Results Of the 20 plastic surgery journals, 13 (65%) did not mention a single guideline within their instructions to authors. Furthermore, 10 (50%) did not mention policies regarding clinical trial registration. In addition, journals with policies regarding the CONSORT statement were more likely to publish trials with a CONSORT flow diagram, and journals with policies regarding clinical trial registry were more likely to publish trials reporting registration. Conclusion and Relevance Our study found that few plastic surgery journals mention reporting guidelines or trial registration in their instructions for authors. Our study also found that journal policies regarding guideline adherence and trial registration seem to be effective mechanisms toward improvement, and plastic surgery journals should consider adopting such policies.
The devil is in the detail: Nonadditive and context‐dependent plant population responses to increasing temperature and precipitation

In climate change ecology, simplistic research approaches may yield unrealistically simplistic answers to often more complicated problems. In particular, the complexity of vegetation responses to global climate change begs a better understanding of the impacts of concomitant changes in several climatic drivers, how these impacts vary across different climatic contexts, and of the demographic processes underlying population changes. Using a replicated, factorial, whole‐community transplant experiment, we investigated regional variation in demographic responses of plant populations to increased temperature and/or precipitation. Across four perennial forb species and 12 sites, we found strong responses to both temperature and precipitation change. Changes in population growth rates were mainly due to changes in survival and clonality. In three of the four study species, the combined increase in temperature and precipitation reflected nonadditive, antagonistic interactions of the single climatic changes for population growth rate and survival, while the interactions were additive and synergistic for clonality. This disparity affects the persistence of genotypes, but also suggests that the mechanisms behind the responses of the vital rates differ. In addition, survival effects varied systematically with climatic context, with wetter and warmer + wetter transplants showing less positive or more negative responses at warmer sites. The detailed demographic approach yields important mechanistic insights into how concomitant changes in temperature and precipitation affect plants, which makes our results generalizable beyond the four study species. Our comprehensive study design illustrates the power of replicated field experiments in disentangling the complex relationships and patterns that govern climate change impacts across real‐world species and landscapes.
Synthesis and anti-candidal activity of some new pyrazoline derivatives

New pyrazoline derivatives were synthesized via the reaction of chalcones with cyclohexyl/phenyl thiosemicarbazide in presence of ethanol and acetic acid. All the compounds were confirmed by FT IR, 1H NMR, 13C NMR and MS spectral data. The compounds (1-11) were evaluated for antifungal activity against various strains of Candida species and compared with standard drug Itraconazole. MIC50 values were found to be within the range of 41.099-127.895 μg/ml and MIC90 values were found to be within the range of 62.121-240.955 μg/ml. Compound 7 was found to be most potent antifungal agent against Candida strains. It appears that para-methoxy substitution at one phenyl ring and meta-methoxy substitution at other phenyl ring of pyrazoline moiety made a significant contribution to the anti- Candidal activity in this series of pyrazolines.
Vegetal and Animal Food Proteins Have a Different Impact in the First Postprandial Hour of Impedance-pH Analysis in Patients with Heartburn

Background and Aims By means of 24 h impedance-pH monitoring, we aimed to evaluate the effect of two different meals with a bromatological balanced composition: one with a prevailing component of animal proteins and the other with vegetable proteins. Patients and Methods We enrolled 165 patients with heartburn and negative endoscopy, who underwent impedance-pH monitoring off therapy. Patients were allocated to receive a Mediterranean diet with a total caloric intake of about 1694 kcal, divided into two meals: one with a prevailing component of animal proteins and the other with vegetable proteins. We evaluated the total reflux number, acid exposure time (AET), and symptom-reflux association with impedance-pH analysis. Moreover, during the first postprandial hour (at lunch and dinner), we evaluated the total reflux number, number of acid and weakly acidic refluxes, AET, and presence of symptoms. Results The male/female ratio was 80/85. Mean age was 51.9 ± 12.1 years. Impedance-pH analysis showed that 55/165 patients had pathological AET or a number of refluxes (nonerosive reflux disease (NERD)), 49/165 had normal AET and a number of refluxes but positive symptom-reflux association (hypersensitive esophagus (HE)), and 61/165 had normal AET and a number of refluxes with negative symptom-reflux association (functional heartburn (FH)). The overall first postprandial hour analysis showed a higher total reflux number, acid reflux number, and AET after the animal protein meal than after the vegetable protein meal. Moreover, more symptoms were reported after the animal protein meal. Similar results have been observed in the three different subcategories of patients (NERD, HE, and FH). Conclusions Vegetable proteins are associated with a lower number of refluxes, particularly acid refluxes, and with a reduced number of symptoms during the first postprandial hour. This is a pilot study and future investigations are warranted to confirm these results.
Subcellular Distribution of Cadmium in Two Paddy Rice Varieties with Different Cooking Methods

Cadmium (Cd) is a non-essential element that is highly mobile within organisms where, following plant uptake, subcellular distribution plays an important role in plant tolerance and detoxification. Cd uptake and subcellular distribution were studied in two paddy rice varieties (Japonica and Indica) hydroponically cultivated in Cd-containing solutions. Japonica rice grains containing Cd were also collected from a Cd-contaminated site and subjected to various cooking treatments (boiled, stir-fried, steamed, and control) to determine the influence of cooking method on the subcellular distribution of Cd. Cd treatment inhibited both shoot height and root length, especially in Japonica, where for the same Cd treatment, Japonica accumulated more Cd in roots and shoots than Indica. Most of the accumulated Cd (92% - 99%) was bound to the cell wall and vacuoles, and decreased in the order: soluble fraction (Fs) > cell wall fraction (Fcw) > organelle fraction (Fco). Subcellular Cd concentrations in rice grains were significantly affected by cooking treatment. The proportion of trophically available Cd decreased with increase in cooking duration and temperature, indicating that consuming steamed and stir-fried rice had a lower Cd exposure risk than consuming boiled rice.
Parents' meal choices for their children at fast food and family restaurants with different menu labeling presentations

BACKGROUND/OBJECTIVES This study examined the effect of nutrition labeling formats on parents' food choices for their children at different restaurant types. SUBJECTS/METHODS An online survey was conducted with 1,980 parents of children aged 3–12 years. Participants were randomly assigned to fast food or family restaurant scenarios, and one of four menu stimuli conditions: no labeling, low-calorie symbol (symbol), numeric value (numeric), and both low-calorie symbol and numeric value (symbol + numeric). Participants selected menu items for their children. Menu choices and total calories were compared by nutrition labeling formats in each type of the restaurant. RESULTS Low-calorie item selections were scored and a two-way analysis of variance (ANOVA) was conducted for an interaction effect between restaurant and labeling type. In the fast food restaurant group, parents presented with low-calorie symbols selected the lowest calorie items more often than those not presented with the format. Parents in the symbol + numeric condition selected significantly fewer calories (653 kcal) than those in the no labeling (677 kcal) or numeric conditions (674 kcal) (P = 0.006). In the family restaurant group, no significant difference were observed among different labeling conditions. A significant interaction between restaurant and labeling type on low-calorie selection score (F = 6.03, P < 0.01) suggests that the effect of nutrition labeling format interplays with restaurant type to jointly affect parents' food choices for their children. CONCLUSIONS The provision of easily interpretable nutritional information format at fast food restaurants may encourage healthier food choices of parents for their children; however, the effects were negligible at family restaurants.
Effects of abiotic environmental factors and land use on the diversity of carrion-visiting silphid beetles (Coleoptera: Silphidae): A large scale carrion study

Anthropogenic land use causes global declines in biodiversity. Despite the knowledge that animal carrion is the most nutrient-rich form of dead organic matter, studies on landscape and local scales determining whether and the means by which land use intensity influences the diversity of the carrion-associated insect fauna are globally scarce. We investigated the effects of land use intensity and abiotic and biotic environmental factors on the abundance, species richness, and diversity of the important ecosystem-service-providing silphid beetle taxon (carrion beetles) in three regions of Germany. In 61 forest stands distributed over three geographically distinct regions in Central Europe, we trapped silphid beetles on exposed piglet cadavers during late summer. In all three regions, higher ambient temperatures and higher fine sand contents were associated with the abundance of the silphid beetle taxa. The carrion community silphid diversity was negatively affected by an increase in mean ambient temperature in all three regions. Although management intensity in forests did not affect the overall abundance of Silphidae, the abundance of Nicrophorus humator decreased significantly with higher forest management intensity across all three regions. Unmanaged and age-class forests showed a higher abundance of N. humator compared with extensively managed forest stands. These findings indicate that N. humator has potential as an indicator species for anthropogenic disturbances in forests. Overall, the direct responses of the silphid beetle community to diverse soil characteristics underline soil as an important factor determining the abundance and diversity of necrophagous carrion beetles in Central Europe. To protect these valuable ecosystem-service providers, forest-management-induced soil modifications need to be paid close attention.
Heckman ' s methodology for correcting selectivity bias : an application to road crash costs

Aggregate road crash costs are traditionally determined using average costs applied to incidence figures found in Police-notified crash data. Such data only comprise a non-random sample of the true population of road crashes, the bias being due to the existence of crashes that are not notified to the Police. The traditional approach is to label the Police-notified sample as 'non-random' thereby casting a cloud over data analyses using this sample. Heckman however viewed similar problems as 'omitted variables' problems in that the exclusion of some observations in a systematic manner (so-called selectivity bias) has inadvertently introduced the need for an additional regressor in the least squares procedures. Using Heckman's methodology for correcting for this selectivity bias, Policenotified crash data for Western Australia in 1987/88 is reconciled with total (notified and not notified) crash data in the estimation of the property damage costs of road crashes. Acknowledgments: The author wishes to thank Professor Paul Miller, The University of Western Australia, for support and valuable comments, as well as session participants at the presentation of an earlier version of this paper at the School of Finance and Business Economics Seminar Series, Edith Cowan University, Western Australia, February 23, 2001.
STATCOM Estimation Using Back-Propagation, PSO, Shuffled Frog Leap Algorithm, and Genetic Algorithm Based Neural Networks

Different optimization techniques are used for the training and fine-tuning of feed forward neural networks, for the estimation of STATCOM voltages and reactive powers. In the first part, the paper presents the voltage regulation in IEEE buses using the Static Compensator (STATIC) and discusses efficient ways to solve the power systems featuring STATCOM by load flow equations. The load flow equations are solved using iterative algorithms such as Newton-Raphson method. In the second part, the paper focuses on the use of estimation techniques based on Artificial Neural Networks as an alternative to the iterative methods. Different training algorithms have been used for training the weights of Artificial Neural Networks; these methods include Back-Propagation, Particle Swarm Optimization, Shuffled Frog Leap Algorithm, and Genetic Algorithm. A performance analysis of each of these methods is done on the IEEE bus data to examine the efficiency of each algorithm. The results show that SFLA outperforms other techniques in training of ANN, seconded by PSO.
Tumor necrosis factor-related protein-3 protects macrophages against LPS-induced lipid accumulation , inflammation and phenotype transition via PPARγ and TLR 4-mediated pathways

Macrophage inflammation and foam cell formation are critical events during the initiation and development of atherosclerosis (AS). C1q/tumor necrosis factor-related protein-3 (CTRP3) is a novel adipokine with anti-inflammatory and cardioprotection properties; however, little is known regarding the influence of CTRP3 on AS. As macrophages play a key role in AS, this study investigated the effects of CTRP3 on macrophage lipid metabolism, inflammatory reactions, and phenotype transition, as well as underlying mechanisms, to reveal the relationship between CTRP3 and AS. CTRP3 reduced the number of lipid droplets, lowered cholesteryl ester (CE), total cholesterol (TC), and free cholesterol (FC) levels, reduced the CE/TC ratio, and dose-dependently inhibited TNFα, IL-6, MCP-1, MMP-9 and IL1β release in lipopolysaccharide (LPS)-stimulated THP-1 macrophages and mouse peritoneal macrophages. Pretreatment with CTRP3 effectively increased macrophage transformation to M2 macrophages rather than M1 macrophages. Western blotting showed that the specific NF-κB pathway inhibitor ammonium pyrrolidine dithiocarbamate (PDTC) or siRNA targeting PPARγ/LXRα markedly strengthened or abolished the above-mentioned effects of CTRP3, respectively. These results show that CTRP3 inhibits TLR4-NF-κB pro-inflammatory pathways but activates the PPARγLXRα-ABCA1/ABCG1 cholesterol efflux pathway. Taken together, CTRP3 participates in anti-lipid accumulation, anti-inflammation and macrophage phenotype conversion via the TLR4-NF-κB and PPARγ-LXRα-ABCA1/ABCG1 pathways and, thus, may have anti-atherosclerotic properties.
Prevalence of Hepatitis B and C virus infection and their co-relation with hematological and hepatic parameters in subjects undergoing Premarital Screening in the Jazan Region, Kingdom of Saudi Arabia

Objective: Hepatitis is a serious health concern with a high rate of mortality and morbidity world over. Saudi Arabia also has its course of the disease incidence. The data on the prevalence of the disease is still limiting. This study aimed to estimate the prevalence of hepatitis B virus [HBV] and hepatitis C virus [HCV] infection in the Jazan region and study its effects on hematological and hepatic parameters. Methods: This cross-sectional study was conducted at premarital screening centre located in King Fahd Central Hospital, Jazan, Kingdom of Saudi Arabia. A total of 7,826, Saudi couples undertaking premarital screening from Jazan region, were enrolled in the study and screened between January 2014 and June 2015 for hepatitis B virus and hepatitis C virus. Complete blood counts and hepatic profile were carried out for individuals who were Hepatitis B and or C virus positive. Results: A higher prevalence of hepatitis virus infection in male participants [HBV 1.9%; HCV 0.4%] than in females [HBV 1.43%; HCV 0.2%] was seen. The neutrophil-to-lymphocyte (NLR) and platelet-to-lymphocyte (PLR) ratios were significantly decreased among HBV- and HCV-infected patients. The concentration of hepatic enzymes showed a statistically significant increase in seropositive individuals. The levels of albumin were significantly decreased in individuals with hepatitis B and C when compared with the control group Conclusions: The study concludes that the prevalence of HBV infection among Saudi subjects in Jazan was higher than the prevalence of HCV infection, and both HBV and HCV were higher in men than in women.
Prophets and Secretaries with Overbooking

The prophet and secretary problems demonstrate online scenarios involving the optimal stopping theory. In a typical prophet or secretary problem, selection decisions are assumed to be immediate and irrevocable. However, many online settings accommodate some degree of revocability. To study such scenarios, we introduce the l-out-of- k setting, where the decision maker can select up to k elements immediately and irrevocably, but her performance is measured by the top l elements in the selected set. Equivalently, the decision makes can hold up to l elements at any given point in time, but can make up to k-l returns as new elements arrive. We give upper and lower bounds on the competitive ratio of l-out-of- k prophet and secretary scenarios. For l-out-of- k prophet scenarios we provide a single-sample algorithm with competitive ratio 1-l· e-Θ((k-l)2/k) . The algorithm is a single-threshold algorithm, which sets a threshold that equals the (l+k/2)th highest sample, and accepts all values exceeding this threshold, up to reaching capacity k . On the other hand, we show that this result is tight if the number of possible returns is linear in l (i.e., k-l =Θ(l)). In particular, we show that no single-sample algorithm obtains a competitive ratio better than 1 - 2-(2k+1)/k+1 . We also present a deterministic single-threshold algorithm for the 1-out-of- k prophet setting which obtains a competitive ratio of 1-3/2 · e-s/k 6, knowing only the distribution of the maximum value. This result improves the result of [Assaf & Samuel-Cahn, J. of App. Prob. , 2000].
Evaluation of the Effects of Photobiomodulation on Partial Osteotomy in Streptozotocin-Induced Diabetes in Rats.

OBJECTIVE We examined the effects of photobiomodulation (PBM) on stereological parameters, and gene expression of Runt-related transcription factor 2 (RUNX2), osteocalcin, and receptor activator of nuclear factor kappa-B ligand (RANKL) in repairing tissue of tibial bone defect in streptozotocin (STZ)-induced type 1 diabetes mellitus (TIDM) in rats during catabolic response of fracture healing. BACKGROUND DATA There were conflicting results regarding the efficacy of PBM on bone healing process in healthy and diabetic animals. MATERIALS AND METHODS Forty-eight rats have been distributed into four groups: group 1 (healthy control, no TIDM and no PBM), group 2 (healthy test, no TIDM and PBM), group 3 (diabetic control, TIDM and no PBM), and group 4 (diabetic test, no TIDM and PBM). TIDM was induced in the groups 3 and 4. A partial bone defect in tibia was made in all groups. The bone defects of groups second and fourth were irradiated by a laser (890 nm, 80 Hz, 1.5 J/cm2). Thirty days after the surgery, all bone defects were extracted and were submitted to stereological examination and real-time polymerase chain reaction (RT-PCR). RESULTS PBM significantly increased volumes of total callus, total bone, bone marrow, trabecular bone, and cortical bone, and the numbers of osteocytes and osteoblasts of callus in TIDM rats compared to those of callus in diabetic control. In addition, TIDM increased RUNX2, and osteocalcin in callus of tibial bone defect compared to healthy group. PBM significantly decreased osteocalcin gene expression in TIDM rats. CONCLUSIONS PBM significantly increased many stereological parameters of bone repair in an STZ-induced TIDM during catabolic response of fracture healing. Further RT-PCR test demonstrated that bone repair was modulated in diabetic rats during catabolic response of fracture healing by significant increase in mRNA expression of RUNX2, and osteocalcin compared to healthy control rats. PBM also decreased osteocalcin mRNA expression in TIDM rats.
Biohybrid robot powered by an antagonistic pair of skeletal muscle tissues

A biohybrid robot actuated by an antagonistic pair of skeletal muscle tissues achieves large and long-term finger-like movements. Biohybrid robots are attracting attention as promising candidates to enhance robot applicability to studies on biological designs and in vitro construction of biological dynamic systems. Rapid progress in biohybrid robots with skeletal muscle tissues formed on a flexible substrate has enabled various types of locomotion powered by muscle tissue. However, it has been difficult to achieve high levels of both large and long-term actuations of the skeletal muscle tissues because of their spontaneous shrinkage through the course of the tissue culture. To overcome this limitation, we adapted the concept of biological systems and developed a biohybrid robot actuated by an antagonistic pair of skeletal muscle tissues. Our robot achieved large actuation (~90° of rotation of a joint) by selective contractions of the skeletal muscle tissues and a long lifetime (~1 week) by balancing tensions of the antagonistic tissues to prevent the spontaneous shrinkage. As a demonstration, we showed that our biohybrid robots allowed a pick-and-place manipulation of objects. This research may provide a platform to exceed the limitations of design in conventional biohybrid robots and replicate various lifelike movements.