Miracle-dz/UniFAR-FTUs huggingface dataset:
Daily affect and female sexual function.

INTRODUCTION The specific affective experiences related to changes in various aspects of female sexual function have received little attention as most prior studies have focused instead on the role of clinical mood and anxiety disorders and their influence on sexual dysfunction. AIM We sought to understand the transaction between daily affect and female sexual function in effort to provide a more nuanced understanding of the interplay between affective and sexual experiences. METHODS The present study used a 2-week daily diary approach to examine same-day and temporal relations between positive and negative affect states and sexual function in young women. MAIN OUTCOME MEASURES We examined the unique relations between positive (i.e., joviality, serenity, self-assurance) and negative (i.e., fear, sadness, hostility) affects and female sexual response (i.e., desire, subjective arousal, vaginal lubrication, orgasmic function, and sexual pain) while controlling for higher order sexual distress, depression, and anxiety, as well as age effects and daily menstruation. RESULTS Analyses revealed different aspects of both positive and negative affects to be independently related to sexual response indices. Specifically, results indicated that joviality was related to same-day sexual desire and predicted increased desire the following day. This latter relation was partially mediated by sexual activity. Further, greater sexual desire predicted next-day calmness, which was partially mediated by sexual activity. Notably, fear was related to same-day subjective arousal, lubrication, orgasmic function, and vaginal pain, whereas poorer orgasmic function predicted greater next-day sadness. CONCLUSIONS These findings describe the manner in which changes in affect correspond to variations in female sexual function, thus highlighting the inextricability of mental and sexual health. Further, these findings may offer insight into the progression of normative levels of affect and sexual function as they develop into comorbid depression, anxiety, and sexual dysfunction.
Expression signatures in lung cancer reveal a profile for EGFR‐mutant tumours and identify selective PIK3CA overexpression by gene amplification

The development of targeted therapies creates a need to discriminate tumours accurately by their histological and genetic characteristics. Here, we aim to identify gene expression profiles and single markers that recapitulate the pathological and genetic background of non‐small cell lung cancer (NSCLC). We performed cDNA microarray analysis on a series of 69 NSCLCs, with known mutation status for important genes, and six normal lung tissues. Unsupervised cluster analysis segregated normal lungs from lung tumours and lung tumours according to their histopathology and the presence of EGFR mutations. Several transcripts were highly overexpressed (by ∼20 times) in squamous cell carcinomas (SCCs) relative to adenocarcinomas (ACs) and confirmed by immunohistochemistry in an independent cohort of 75 lung tumours. Expression of 13 genes constituted the most prominent hallmarks of EGFR‐mutant tumours, including increased levels of proline dehydrogenase (PRODH) and down‐regulation of X‐box binding protein 1 (XBP1). No genes were differentially expressed, with a fold change ≥ 4 or ≤0.25 and a significance level of 5% false‐discovery rate, in tumours carrying mutations of TP53 or KRAS. In addition, we organized gene expression data by the position of each gene in the chromosome and observed a cluster of highly expressed genes in chromosome 3q, including PIK3CA, that was characteristic of SCCs. FISH analysis demonstrated a strong statistically significant association between increased levels of PIK3CA expression in these tumours and gene amplification (p < 0.0001; t‐test). In conclusion, histopathological phenotypes and, likely, the presence of EGFR mutations confer lung tumours with a marked pattern of gene expression. Moreover, our cDNA microarray analysis identified increased PIK3CA expression due to gene amplification in lung squamous cell carcinomas: this may represent a marker of sensitivity to therapy with PI3K inhibitors. Copyright © 2007 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
A study of changes to specific absorption rates in the human eye close to perfectly conducting spectacles within the radio frequency range 1.5 to 3.0 GHz

This paper investigates relative changes in specific absorption rates due to perturbing metallic spectacles in proximity to the face. A representative electrical property biological matter model with 25 distinct tissue types based on magnetic resonance imaging data is used with the finite-difference time-domain method. Both plane wave and dipole stimuli are investigated and are used to represent an excitation from the front of the head. The frequency range investigated is 1.5 to 3.0 GHz. Results show that metallic spectacles may significantly alter SAR level distributions within the head. Specific attention is given to energy interactions with the eyes. Results are given for several common spectacle frame shapes.
Modulatory and plastic effects of kinins on spinal cord networks

Inflammatory kinins are released following spinal cord injury or neurotrauma. The effects of these kinins on ongoing locomotor activity of central pattern generator networks are unknown. In the present study, kinins were shown to have short‐ and long‐term effects on motor networks. The short‐term effects included direct depolarization of interneurons and motoneurons in the ventral horn accompanied by modulation of transient receptor potential vanilloid 1‐sensitive nociceptors in the dorsal horn. Over the long‐term, we observed a bradykinin‐mediated effect on promoting plasticity in the spinal cord. In a model of spinal cord injury, we observed an increase in microglia numbers in both the dorsal and ventral horn and, in a microglia cell culture model, we observed bradykinin‐induced expression of glial‐derived neurotrophic factor.
Nearness to the 52-Week High and Low Prices, Past Returns, and Average Stock Returns

This study examines the interactions between trading strategies based on the nearness to the 52-week high, the nearness to the 52-week low, and past returns. We offer evidence that the nearness to the 52-week low has predictive power for future average returns. Our results also reveal that the nearness to the 52-week high as well as to the 52-week low and past returns each have certain exclusive unpriced information content in the cross-sectional pricing of stocks. Moreover, a trading strategy based on the nearness to the 52-week low provides an excellent hedge for the momentum strategy, thereby nearly doubling the Sharpe ratio of the momentum strategy.
Analysis of PCB subassembly dynamic responses using integrated analytical, numerical and experimental techniques

The mechanical shock causes multiple PCB bending or vibration which induces the solder joint fatigue failure. The solder joint failures are strongly dependent on many factors. In particular, PCB design and mounting method is one of the key factors. It determines the dynamic responses, and the degree of PCB flexing which is the root cause of solder joint failure. In this paper, dynamic strains of PCB are measured and analyzed in detail with a real-time electrical monitoring system. The effects of test variables, such as drop height, number of PCB mounting screws, and tightness of screws, are studied by comparing and analyzing the dynamic responses. Frequency domain analysis is introduced to perform advanced spectrum analysis on the dynamic responses of PCB during drop impact. Spectrums of impact pulse and dynamic strains are obtained by using fast Fourier transform (FFT) technique. Bending mode shapes and frequencies of PCB extracted from strain spectrums are consistent with the results of modal analysis by finite element modeling. Knowledge of spectrums of PCB dynamic responses is very important to understand the PCB bending characteristics which affect the solder joint reliability. Most of the fundamental modes of PCB with frequencies lower than 2.5kHz are excited during drop impact. The first mode is the dominant one. From the spectrum analysis, it is clear that the bending mode shapes and frequencies are unique for different PCB mounting configurations.
SUMO Pathway Dependent Recruitment of Cellular Repressors to Herpes Simplex Virus Type 1 Genomes

Components of promyelocytic leukaemia (PML) nuclear bodies (ND10) are recruited to sites associated with herpes simplex virus type 1 (HSV-1) genomes soon after they enter the nucleus. This cellular response is linked to intrinsic antiviral resistance and is counteracted by viral regulatory protein ICP0. We report that the SUMO interaction motifs of PML, Sp100 and hDaxx are required for recruitment of these repressive proteins to HSV-1 induced foci, which also contain SUMO conjugates and PIAS2β, a SUMO E3 ligase. SUMO modification of PML and elements of its tripartite motif (TRIM) are also required for recruitment in cells lacking endogenous PML. Mutants of PML isoform I and hDaxx that are not recruited to virus induced foci are unable to reproduce the repression of ICP0 null mutant HSV-1 infection mediated by their wild type counterparts. We conclude that recruitment of ND10 components to sites associated with HSV-1 genomes reflects a cellular defence against invading pathogen DNA that is regulated through the SUMO modification pathway.
TGF‐β converts Th1 cells into Th17 cells through stimulation of Runx1 expression

Differentiated CD4+ T cells preserve plasticity under various conditions. However, the stability of Th1 cells is unclear, as is whether Th1 cells can convert into Th17 cells and thereby contribute to the generation of IFN‐γ+IL‐17+CD4+ T cells, the number of which correlates with severity of colitis. We investigated whether IFN‐γ+Th1 cells can convert into Th17 cells under intestinal inflammation and the mechanisms involved. IFN‐γThy1. 1+ Th1 cells were generated by culturing naïve CD4+ T cells from IFN‐γThy1. 1 CBir1 TCR‐Tg reporter mice, whose TCR is specific for an immunodominant microbiota antigen, CBir1 flagellin, under Th1 polarizing conditions. IFN‐γThy1. 1+ Th1 cells induced colitis in Rag−/− mice after adoptive transfer and converted into IL‐17+Th17, but not Foxp3+Treg cells in the inflamed intestines. TGF‐β and IL‐6, but not IL‐1β and IL‐23, regulated Th1 conversion into Th17 cells. TGF‐β induction of transcriptional factor Runx1 is crucial for the conversion, since silencing Runx1 by siRNA inhibited Th1 conversion into Th17 cells. Furthermore, TGF‐β enhanced histone H3K9 acetylation but inhibited H3K9 trimethylation of Runx1‐ and ROR‐γt‐binding sites on il‐17 or rorc gene in Th1 cells. We conclude that Th1 cells convert into Th17 cells under inflammatory conditions in intestines, which is possibly mediated by TGF‐β induction of Runx1.
An Empirical Analysis of the Determinants of Interest Rates in Ghana

ABSTRACT This paper provides an empirical analysis of the determinants of the bank lending rate in Ghana using annual time series data from 1970 to 2013. We found evidence of a long-run equilibrium relationship between the average lending rate charged by commercial banks and its determining factors. In the long run, bank lending rates in Ghana are positively influenced by nominal exchange rates and Bank of Ghana’s monetary policy rate but negatively with fiscal deficit, real GDP and inflation. We also find positive dependence of the bank lending rate on exchange rates, and the monetary policy rate both in the short and long run. Specifically, our findings reveal that the Bank of Ghana’s monetary policy rate and the exchange rate, by far, show strong contemporaneous effects on the average bank lending rate in Ghana.
An after-school obesity prevention program for African-American girls: the Minnesota GEMS pilot study.

OBJECTIVE This paper describes the development of an after-school obesity-prevention program for African-American girls, and presents findings from a 12-week pilot trial conducted by the University of Minnesota. This study was part of the GEMS project, created to test interventions designed to reduce excess weight gain in African-American girls. DESIGN Two-arm parallel group, randomized controlled trial. Measures were taken at baseline and at 12 weeks follow up. SETTING An after-school community program. PARTICIPANTS Fifty-four African-American girls, 8- to 10-years of age, and their parents/caregivers. INTERVENTION The after-school intervention was conducted twice a week for 12 weeks, and focused on increasing physical activity and healthy eating. A family component was also included. Girls in the control group received a program over 12 weeks unrelated to nutrition and physical activity. OUTCOMES Measures included height and weight (body mass index), percent body fat (DEXA), physical activity, assessed using a CSA accelerometer and self-report, two 24-hour dietary recalls, and psycho-social and demographic variables. Parental data included demographic and psycho-social characteristics, and dietary measures. Additionally, process evaluation data on the intervention were collected. RESULTS Recruitment goals were met. After adjustment for baseline level, follow-up BMI did not differ between the treatment groups, an expected finding, given that this was a pilot study. At 12 weeks follow up, differences between the intervention and control groups were in the hypothesized direction of change for most variables, among both the girls and their parents. Process evaluation results demonstrated that the program was well attended, and well received, by girls and parents. CONCLUSIONS An after-school obesity prevention program for low-income African-American girls is a promising model for future efforts.
A method of voltage stability evaluation for branch and generator outage contingencies

This paper proposes a fast computation method to evaluate the load power margins with respect to saddle node bifurcations under branch outage as well as generator outage contingencies. The voltage stability evaluation for generator outages is a new topic, while there exist various studies for the branch outage contingencies. The proposed method is based on the conventional linear sensitivity method. The linear estimations are improved by taking into account nonlinearities of the power flow equations and by using a fast line search technique. Compared with existing methods, the accuracy is considerably improved. The effectiveness of the proposed method is demonstrated through IEEE 14-, 30-, and 57-bus systems. The estimation errors in load power margins are not more than 5% for generator outage and 15% for all branch outage (route open outage) contingencies.
Serum levels of interleukin-10 in patients with diffuse large cell lymphoma: lack of correlation with prognosis.

Interleukin-10 (IL-10), also known as cytokine synthesis inhibitory factor, has multiple effects on lymphoid development. In addition, it has been previously reported that serum levels of IL-10 correlate with failure-free and overall survival in patients with non-Hodgkin's lymphoma. In this study, we used a sensitive enzyme-linked immunosorbent assay specific for human IL-10 (lower limit of sensitivity, 5 pg/mL) to measure serum levels in 52 newly diagnosed patients with diffuse large cell lymphoma and at least one adverse prognostic feature who were subsequently treated in a uniform way. Lymphoma patients had significantly higher serum levels of IL-10 (median, 7.98 pg/mL; range, < or = 5 to 27,143 pg/mL) than healthy volunteers (N = 50; median, < or = 5 pg/mL; range, < or = 5 to 19.21 pg/mL) (P = .0000012). Individuals with B symptoms had significantly higher serum levels of IL-10 than those without them (P = .03), but there was no correlation between IL-10 levels and any of the other prognostic variables analyzed, including age, lactic dehydrogenase, beta 2-microglobulin levels, performance status, bulky disease, Ann Arbor stage, or International Index score. More importantly, we found no correlation between IL-10 levels and the achievement of complete remission, nor with failure-free survival or overall survival. We conclude that in a uniform population of untreated patients with diffuse large cell lymphoma, serum levels of IL-10 do not appear to have any prognostic value.
Association of arrhythmia and sudden death in macrocephaly-cutis marmorata telangiectatica congenita syndrome.

Macrocephaly-cutis marmorata telangiectatica congenita (M-CMTC) constitutes a distinct entity characterized by prenatal overgrowth, macrosomia, hemihypertrophy, macrocephaly, nonobstructive hydrocephaly, frontal bossing, hypotonia, developmental delay, generalized or facial capillary malformation with upper philtral nevus flammeus and cutis marmorata, joint hypermobility, loose skin, toe syndactyly, and postaxial polydactyly. All but one of the cases reported previously had benign clinical courses without showing an increased risk of early infant death. We describe three additional cases with poor clinical outcomes including severe postnatal growth failure, intractable cardiac arrhythmia in two cases, and sudden infant death in two cases. Arrhythmia has not been described previously as one of the symptoms of M-CMCT. Patients with M-CMTC associated with severe postnatal growth failure and arrhythmia may constitute a distinct clinical subtype of M-CMTC with an increased risk of life-threatening episodes or sudden death. Recognizing this clinical subtype of M-CMTC is important to prevent these serious potential complications.
A cross-sectional comparison of three self-reported functional indices in scleroderma.

OBJECTIVES In scleroderma, outcome measures such as skin score provide only limited information about the functional impact of the disease. The requirement for validated and convenient instruments that reliably reflect disease morbidity is now recognized. This study compares the Disability Index of the Health Assessment Questionnaire (HAQ-DI) with two more recently developed scleroderma-specific tools: scleroderma-visual analogue scales (scleroderma-VAS) and the UK scleroderma Functional Score (UKFS). In addition, the use of clinical and laboratory measures as predictors of disease severity have been examined. METHODS One hundred and fifteen consecutive patients were studied. Subjects completed the 20-item HAQ-DI, the scleroderma-VAS and a questionnaire related to hand and muscle function (UKFS). Clinical details, measurement of maximal hand-spread, fist-closure and investigations for internal organ involvement were recorded. RESULTS Over 68% of patients with diffuse disease had moderate to severe disease on the UKFS, compared with 44% with limited disease. The mean UKFS in diffuse disease was 14.7 (s.d. 9.1) and 10.6 (s.d. 8.5) in the limited subset (P=0.02). The mean HAQ-DI in diffuse disease was 1.23 (s.d. 0.77) and 0.79 (s.d. 0.75) in the limited subset (P=0.005). The HAQ-DI showed significant correlation with UKFS (r=0.9; P < 0.001). Several clinical and laboratory measures were associated with higher HAQ-DI and UKFS. CONCLUSIONS This is the first comparative study of the UKFS and the HAQ-DI. These data show a strong correlation between assessment methods. Higher scores correlated with clinical and laboratory indicators of severe disease. Used together, these inexpensive tools assess general and organ-specific symptoms, as well as functional limitation.
Relationships between aboveground biomass and plant cover at two spatial scales and their determinants in northern Tibetan grasslands

Abstract The relationships between cover and AGB for the dominant and widely distributed alpine grasslands on the northern Tibetan Plateau is still not fully examined. The objectives of this study are to answer the following question: (1) How does aboveground biomass (AGB) of alpine grassland relate to plant cover at different spatial scales? (2) What are the major biotic and abiotic factors influencing on AGB–cover relationship? A community survey (species, cover, height, and abundance) was conducted within 1 m × 1 m plots in 70 sites along a precipitation gradient of 50–600 m. Ordinary linear regression was employed to examine AGB–cover relationships of both community and species levels at regional scale of entire grassland and landscape scale of alpine meadow, alpine steppe, and desert steppe. Hierarchical partitioning was employed to estimate independent contributions of biotic and abiotic factors to AGB and cover at both scales. Partial correlation analyses were used to discriminate the effects of biotic and abiotic factors on AGB–cover relationships at two spatial scales. AGB and community cover both exponentially increased along the precipitation gradient. At community level, AGB was positively and linearly correlated with cover for all grasslands except for alpine meadow. AGB was also linearly correlated with cover of species level at both regional and landscape scales. Contributions of biotic and abiotic factors to the relationship between AGB and cover significantly depended on spatial scales. Cover of cushions, forbs, legumes and sedges, species richness, MAP, and soil bulk density were important factors that influenced the AGB–cover relationship at either regional or landscape scale. This study indicated generally positive and linear relationships between AGB and cover are at both regional and landscape scales. Spatial scale may affect ranges of cover and modify the contribution of cover to AGB. AGB–cover relationships were influenced mainly by species composition of different functional groups. Therefore, in deriving AGB patterns at different spatial scales, community composition should be considered to obtain acceptable accuracy.
Crustal fluid and ash alteration impacts on the biosphere of Shikoku Basin sediments, Nankai Trough, Japan

We present data from sediment cores collected from IODP Site C0012 in the Shikoku Basin. Our site lies at the Nankai Trough, just prior to subduction of the 19 Ma Philippine Sea plate. Our data indicate that the sedimentary package is undergoing multiple routes of electron transport and that these differing pathways for oxidant supply generate a complex array of metabolic routes and microbial communities involved in carbon cycling. Numerical simulations matched to pore water data document that Ca2+ and Cl1‐ are largely supplied via diffusion from a high‐salinity (44.5 psu) basement fluid, which supports the presence of halophile Archean communities within the deep sedimentary package that are not observed in shallow sediments. Sulfate supply from basement supports anaerobic oxidation of methane (AOM) at a rate of ~0.2 pmol cm−3 day−1 at ~400 mbsf. We also note the disappearance of δ‐Proteobacteria at 434 mbsf, coincident with the maximum in methane concentration, and their reappearance at 463 mbsf, coinciding with the observed deeper increase in sulfate concentration toward the basement. We did not, however, find ANME representatives in any of the samples analyzed (from 340 to 463 mbsf). The lack of ANME may be due to an overshadowing effect from the more dominant archaeal phylotypes or may indicate involvement of unknown groups of archaea in AOM (i.e., unclassified Euryarchaeota). In addition to the supply of sulfate from a basement aquifer, the deep biosphere at this site is also influenced by an elevated supply of reactive iron (up to 143 μmol g−1) and manganese (up to 20 μmol g−1). The effect of these metal oxides on the sulfur cycle is inferred from an accompanying sulfur isotope fractionation much smaller than expected from traditional sulfate‐reducing pathways. The detection of the manganese‐ and iron‐reducer γ‐Proteobacteria Alteromonas at 367 mbsf is consistent with these geochemical inferences.