Miracle-dz/UniFAR-FTUs huggingface dataset:
Data-Driven Indoor Scene Modeling from a Single Color Image with Iterative Object Segmentation and Model Retrieval

We propose a new method for modeling the indoor scene from a single color image. With our system, the user only needs to drag a few semantic bounding boxes surrounding the objects of interest. Our system then automatically finds the most similar 3D models from the ShapeNet model repository and aligns them with the corresponding objects of interest. To achieve this, each 3D model is represented as a group of view-dependent representations generated from a set of synthesized views. We iteratively conduct object segmentation and 3D model retrieval, based on the observation that good segmentation of the objects of interest can significantly improve the accuracy of model retrieval and make it robust to cluttered background and occlusions, and in turn, the retrieved 3D models can be used to assist with object segmentation. Segmentation of all objects of interest is achieved simultaneously under a unified multi-labeling framework which fully utilizes the correspondences between the objects of interest and retrieved model images. Besides, we propose a new method to estimate the scene layout of the input image with the segmentation masks, which helps compose the resulting scene and further improves the modeling result remarkably. We verify the effectiveness of our approach through experimenting with a variety of indoor images and comparing against the relevant methods.
Characterizing the Normative Voice Tremor Frequency in Essential Vocal Tremor

Importance Essential vocal tremor (EVT) is a neurologic voice disorder characterized by periodic fluctuations in pitch and loudness that can hinder intelligibility. Defining the normative range of vocal tremor frequency may assist in diagnosis and provide insight into disease mechanisms. Objective To characterize the normative voice tremor frequency in EVT (in hertz). Design, Setting, and Participants Cross-sectional observational study of 160 patients with EVT. The setting was a tertiary voice center. Participants were identified from a database of consecutive patients diagnosed as having laryngeal movement disorders between January 1, 1990, and April 1, 2017. Main Outcomes and Measures The following 3 methods measured the frequency of tremor experienced by patients with EVT: perceptual method, computerized peak detection method, and laryngeal electromyography method. Within-person and population-level tremor frequencies were compared across modalities to assess measurement reliability and consistency and to characterize the normal distribution of tremor frequencies in this population. Results Among 160 participants (median age, 70 years; interquartile range [IQR], 64-77 years; 90.6% female [n = 145]), the median frequency of EVT was consistently between 4 and 5 Hz across all 3 methods (perceptual, 4.8 Hz [IQR, 4.4-5.5 Hz]; computerized peak detection, 4.6 Hz [IQR, 4.2-5.0 Hz]; and laryngeal electromyography, 4.3 Hz [IQR, 3.8-5.0 Hz]). The mean in-person differences between each measurement method were not clinically meaningful (range, 0.1-0.5 Hz). Including all interquartile ranges across measurement modalities, the normative tremor frequency range for EVT was 3.8 to 5.5 Hz. Conclusions and Relevance To our knowledge, this is the largest study to date to characterize the normal frequency of tremor in patients with EVT. The normative frequency of EVT (range, 3.8-5.5 Hz) falls within a much narrower range than previously reported. Those whose frequency is outside this range may still have EVT but should be carefully evaluated for potential other causes of vocal tremor. Defining characteristics of EVT may aid appropriate diagnosis and improve understanding of this disease.
Prevalence of False-Negative Results of Intraoperative Consultation on Surgical Margins During Resection of Gastric and Gastroesophageal Adenocarcinoma

Importance Intraoperative consultation (IOC) on surgical margins during curative intent resection of gastric and gastroesophageal adenocarcinoma presents sampling and interpretive challenges. A false-negative (FN) IOC result can affect clinical care. Many factors may be associated with higher risk for an FN result of IOC on surgical margins. Objective To assess the prevalence and clinical implications of FN results of IOC on surgical margins during resection of gastric and gastroesophageal adenocarcinoma. Design, Setting, and Participants This retrospective study assessed the results of IOC on surgical margins to determine the prevalence of FN results and the accuracy and clinical implications of the results for patients undergoing curative intent resection for gastric or gastroesophageal adenocarcinoma. The study examined patients with gastric or gastroesophageal adenocarcinoma who underwent resection with curative intent at a single-institution referral center from January 1, 1992, to December 31, 2015. Interventions Curative intent gastric and/or esophageal resection. Main Outcomes and Measures False-negative results of IOC on surgical margins, accuracy of the results, factors associated with decreased accuracy of the results, and clinical implications of FN results. Results This study included 2002 patients (median age, 65 years; 1343 [67.1%] male; 1638 [81.8%] white) who received 3171 IOCs on surgical margins. Of the 3171 IOCs, the prevalence of FN results was 1.7%, with an accuracy of 98.1%. The prevalence of an FN IOC result was 1.2% for esophageal margins, 2.0% for gastric margins, and 2.5% for duodenal margins (P = .04). The prevalence of an FN IOC result was higher for patients with diffuse or signet ring disease compared with those without (2.6% vs 1.2%, P = .002) and for those not receiving neoadjuvant radiotherapy compared with those receiving neoadjuvant radiotherapy (1.4% vs 0.7%, P < .001). The prevalence of FN results of IOCs performed by nongastrointestinal pathologists was similar to that of IOCs performed by gastrointestinal pathologists (2.3% vs 1.9%, P = .60). The disease-specific survival was 34 months (95% CI, 20.7-47.2 months) for those with an FN result and 26.9 months (95% CI, 18.3-35.4; P = .72) for those with a true-positive result. Half of the patients with FN IOC results received further margin-directed therapy, including subsequent resection or radiotherapy. Conclusions and Relevance This study found that IOC on surgical margins was accurate at a specialty center. Signet ring or diffuse disease, duodenal margins, and not receiving neoadjuvant radiotherapy were challenging scenarios for IOC on surgical margins. The use of IOC on surgical margins may be optimal when it will affect intraoperative decision making framed by the stage of disease, tumor location, and surgical fitness of the patient.
Translating Natural Language to SQL using Pointer-Generator Networks and How Decoding Order Matters

Translating natural language to SQL queries for table-based question answering is a challenging problem and has received significant attention from the research community. In this work, we extend a pointer-generator and investigate the order-matters problem in semantic parsing for SQL. Even though our model is a straightforward extension of a general-purpose pointer-generator, it outperforms early works for WikiSQL and remains competitive to concurrently introduced, more complex models. Moreover, we provide a deeper investigation of the potential order-matters problem that could arise due to having multiple correct decoding paths, and investigate the use of REINFORCE as well as a dynamic oracle in this context.
Assessment of executive function using the Tinkertoy test

The Tinkertoy test (TTT) has often been used to assess executive function. Despite its clinical importance, there are few published normative data for it. Thus, the primary aim of this study was to fill this gap. Moreover, as there exists a sex difference in many cognitive abilities and neuropsychological tests, a secondary aim was to examine whether sex influences TTT performance. We administered the TTT to 25 healthy men and 25 healthy women whose average age was 28 years. Performances were scored based upon Lezak’s (1982) original TTT criteria. On average, our participants used 43 pieces to complete their construction (SD=8), with a range of 21–50, and their complexity scores ranged from 7 to 12, with a mean score of 9.68 (SD=1.35). Overall performance did not differ based on sex; yet, when examining individual scoring criteria, we found that men scored significantly higher on the symmetry measure. Efforts towards the development of adequate normative data for the TTT and different tests of executive functioning are crucial to neuropsychologists’ and other healthcare providers’ ability to reliably diagnose and treat disorders of cognition that affect executive function. The present data go some way towards enhancing the utility of the TTT.
A Protein Complex from Human Milk Enhances the Activity of Antibiotics and Drugs against Mycobacterium tuberculosis

Mycobacterium tuberculosis, the causative agent of human tuberculosis (TB), has surpassed HIV/AIDS as the leading cause of death from a single infectious agent. The increasing occurrence of drug-resistant strains has become a major challenge for health care systems and, in some cases, has rendered TB untreatable. ABSTRACT Mycobacterium tuberculosis, the causative agent of human tuberculosis (TB), has surpassed HIV/AIDS as the leading cause of death from a single infectious agent. The increasing occurrence of drug-resistant strains has become a major challenge for health care systems and, in some cases, has rendered TB untreatable. However, the development of new TB drugs has been plagued with high failure rates and costs. Alternative strategies to increase the efficacy of current TB treatment regimens include host-directed therapies or agents that make M. tuberculosis more susceptible to existing TB drugs. In this study, we show that HAMLET, an α-lactalbumin–oleic acid complex derived from human milk, has bactericidal activity against M. tuberculosis. HAMLET consists of a micellar oleic acid core surrounded by a shell of partially denatured α-lactalbumin molecules and unloads oleic acid into cells upon contact with lipid membranes. At sublethal concentrations, HAMLET potentiated a remarkably broad array of TB drugs and antibiotics against M. tuberculosis. For example, the minimal inhibitory concentrations of rifampin, bedaquiline, delamanid, and clarithromycin were decreased by 8- to 16-fold. HAMLET also killed M. tuberculosis and enhanced the efficacy of TB drugs inside macrophages, a natural habitat of M. tuberculosis. Previous studies showed that HAMLET is stable after oral delivery in mice and nontoxic in humans and that it is possible to package hydrophobic compounds in the oleic acid core of HAMLET to increase their solubility and metabolic stability. The potential of HAMLET and other liprotides as drug delivery and sensitization agents in TB chemotherapy is discussed here.
Consensus on interprofessional facilitator capabilities

ABSTRACT Interprofessional education is one of many strategies aimed at addressing the healthcare workforce crisis. Few educators in healthcare professions have been exposed to interprofessional education (IPE) or have experienced collaborative practice (CP), because health professionals have traditionally been trained in silos. Interprofessional facilitators must acquire a new skillset as expert facilitation of learning is essential for successful interprofessional education. Seven experts participated in a Delphi survey to reach consensus on the capabilities required of interprofessional facilitators. All capabilities discussed should be included in the faculty development programme based on 80% agreement, standard deviation <1.5 and content validity index ≥. 8. However, facilitation of learning, teamwork, role clarification as well as development of reflexivity is less essential than the other capabilities based on the low content validity ratio of . 43. Surprisingly, and contrary to literature, the use of standardised tools that incorporate social determinants of health seems not to be essential with a content validity ratio (CVR) of −. 14. Interprofessional facilitator capabilities that may promote transformative learning in health profession students have been identified and prioritised. These interprofessional facilitator capabilities are deemed to be essential for the development of an effective and collaborative healthcare workforce.
Age-Related Decline in Item But Not Spatiotemporal Associative Memory for a Real-World Event

Normal aging is typically associated with reduced ability to reconstruct the spatiotemporal context of past events, a core component of episodic memory. However, little is known about our ability to remember the order of events comprising extended real-world experiences and how this ability changes with age. We leveraged the richness and structure of a museum exhibit to address this question. Three months after visiting the exhibit, 141 adults aged 18–84 completed a test of spatiotemporal order memory and old/new recognition using pictures from the exhibit and similar lures, from which measures of associative and item memory were derived. Order discrimination accuracy was modulated by interitem order and distance in younger and older adults, extending findings from recognition of laboratory stimuli at short delays to remote real-world experiences. In contrast to established findings from laboratory-based assessments, we observed a significant effect of aging on item memory driven by increased lure susceptibility, but no age-related reduction in spatiotemporal associative memory. These findings present novel insights into different components of memory for real-world experiences at naturalistic timescales and across the lifespan.
Precision oncology: separating the wheat from the chaff

Precision oncology based on next-generation sequencing (NGS) test is growing in daily clinical practice. However, the real impact of this strategy in patients’ outcome on a large scale remains uncertain. In this review, we summarise existing literature on this topic, limitations for broad NGS implementation, bottlenecks in genomic variant interpretation and the role of molecular tumour boards.
Osteogenic potential of gingival stromal progenitor cells cultured in platelet rich fibrin is predicted by core-binding factor subunit-α1/Sox9 expression ratio ( in vitro)

Background: Alveolar bone defect regeneration has long been problematic in the field of dentistry. Gingival stromal progenitor cells (GSPCs) offer a promising solution for alveolar bone regeneration. In order to optimally differentiate and proliferate progenitor cells, growth factors (GFs) are required. Platelet rich fibrin (PRF) has many GFs and can be easily manufactured. Core-binding factor subunit-α1 (CBF-α1) constitutes a well-known osteogenic differentiation transcription factor in SPCs. Sox9, as a chondrogenic transcription factor, interacts and inhibits CBF-α1, but its precise role in direct in vitro osteogenesis remains unknown. GSPCs cultured in vitro in PRF to optimally stimulate osteogenic differentiation has been largely overlooked. The aim of this study was to analyze GSPCs cultured in PRF osteogenic differentiation predicted by CBF-α1/Sox9. Methods: This study used a true experimental with post-test only control group design and random sampling. GPSCs isolated from the lower gingiva of four healthy, 250-gram, 1-month old, male Wistar rats ( Rattus Novergicus) were cultured for two weeks, passaged every 4-5 days. GSPCs in passage 3-5 were cultured in five M24 plates (N=108; n=6/group) for Day 7, Day 14, and Day 21 in three different mediums (control negative group: αModified Eagle Medium; control positive group: High Glucose-Dulbecco’s Modified Eagle Medium (DMEM-HG) + osteogenic medium; Treatment group: DMEM-HG + osteogenic medium + PRF). CBF-α1 and Sox9 were examined with ICC monoclonal antibody. A one-way ANOVA continued with Tukey HSD test (p<0.05) based on Kolmogorov–Smirnov and Levene's tests (p>0.05) was performed. Results: The treatment group showed the highest CBF-α1/Sox9 ratio (16.00±3.000/14.33±2.517) on Day 7, while the lowest CBF-α1/Sox9 ratio (3.33±1.528/3.67±1.155) occurred in the control negative group on Day 21, with significant difference between the groups (p<0.05). Conclusion: GSPCs cultured in PRF had potential osteogenic differentiation ability predicted by the CBF-α1/sox9 ratio.
Functional and Structural Plasticity of Brain in Elite Karate Athletes

The structural and functional neural differences between the elite karate athletes and control group have been investigated in the concept of this study. 13 elite karate athletes and age-gender matched 13 volunteers who have not performed regular exercises participated in the study. Magnetic resonance imaging was used to acquire the anatomical and functional maps. T1-weighted anatomical images were segmented to form gray and white matter images. Voxel-based morphometry is used to elucidate the differences between the groups. Moreover, resting state functional measurements had been done, and group independent component analysis was implemented in order to exhibit the resting state networks. Then, second-level general linear models were used to compute the statistical maps. It has been revealed that increased GM volume values of inferior/superior temporal, occipital, premotor cortex, and temporal pole superior were present for the elite athletes. Additionally, WM values were found to be increased in caudate nucleus, hypothalamus, and mammilary region for the elite karate players. Similarly, for the elite karate players, the brain regions involved in the movement planning and visual perception are found to have higher connectivity values. The differences in these findings can be thought to be originated from the advances gained through the several years of training which is required to be an elite karate athlete.
PennyLane: Automatic differentiation of hybrid quantum-classical computations

PennyLane is a Python 3 software framework for optimization and machine learning of quantum and hybrid quantum-classical computations. The library provides a unified architecture for near-term quantum computing devices, supporting both qubit and continuous-variable paradigms. PennyLane's core feature is the ability to compute gradients of variational quantum circuits in a way that is compatible with classical techniques such as backpropagation. PennyLane thus extends the automatic differentiation algorithms common in optimization and machine learning to include quantum and hybrid computations. A plugin system makes the framework compatible with any gate-based quantum simulator or hardware. We provide plugins for Strawberry Fields, Rigetti Forest, Qiskit, Cirq, and ProjectQ, allowing PennyLane optimizations to be run on publicly accessible quantum devices provided by Rigetti and IBM Q. On the classical front, PennyLane interfaces with accelerated machine learning libraries such as TensorFlow, PyTorch, and autograd. PennyLane can be used for the optimization of variational quantum eigensolvers, quantum approximate optimization, quantum machine learning models, and many other applications.
Functional Characterization of the Gustatory Sensilla of Tarsi of the Female Polyphagous Moth Spodoptera littoralis

Contact chemoreception is crucial for host plant choice selection in insects and is guided by input from gustatory receptor neurons, GRNs, housed in gustatory sensilla. In this study, the morphology and response spectra of individual tarsal sensilla on the fifth tarsomere of females of the moth Spodoptera littoralis were investigated. Two distinct morphological types of gustatory sensilla, TI and TII, were identified. Extracellular electrophysiological recordings were performed on each sensillum type using three sugars, two bitter substances and salt. Three distinct functional classes (TIα, TIβ, TII) were characterized, using cluster analysis based on the response spectra of three of the four responding GRNs. While each functional type of sensillum housed GRNs responding to salt, sugars and bitter compounds, the identity of these cells differed among the functional classes. Interestingly, an interaction between the GRNs responding to sugar and caffeine was found in both TIβ and TII sensilla, when binary mixtures were tested. This study provides a functional screening of the tarsal gustatory sensilla, showing a differentiation between sensilla on the tarsi of S. littoralis, providing the female moth with information that can facilitate host plant choice decisions.
Stationary localized structures and the effect of the delayed feedback in the Brusselator model

The Brusselator reaction–diffusion model is a paradigm for the understanding of dissipative structures in systems out of equilibrium. In the first part of this paper, we investigate the formation of stationary localized structures in the Brusselator model. By using numerical continuation methods in two spatial dimensions, we establish a bifurcation diagram showing the emergence of localized spots. We characterize the transition from a single spot to an extended pattern in the form of squares. In the second part, we incorporate delayed feedback control and show that delayed feedback can induce a spontaneous motion of both localized and periodic dissipative structures. We characterize this motion by estimating the threshold and the velocity of the moving dissipative structures. This article is part of the theme issue ‘Dissipative structures in matter out of equilibrium: from chemistry, photonics and biology (part 2)’.
Differences in Ankle ROM Between Young Men and Women With a History of Ankle Sprain

Abstract Background Ankle injuries are the most common injuries in sports. However, very little is known about sex differences in ankle range of motion (ROM) between ankle joints with an episode of ankle sprain (ASE) and those without an episode of ankle sprain (non-ASE). This study aimed to investigate the differences of ankle ROM between men and women with and without ASE. Methods 26 ASE had at least one episode of ankle injury in the last 6 to 12 months. 35 non-ASE served as a control group. All subjects were examined in supine position and the ankle ROM was calculated by the sum of inversion (IV), eversion (EV), plantar flexion (PF) and dorsiflexion (DF) in both ankles. Results Subjects with ASE had a significantly smaller ROM regarding EV than non-ASE subjects in both ankles. The male subjects with ASE had a significantly higher EV and IV compared with the female subjects. However, ROM in PF was significantly lower among men compared with women who had ASE. Conclusions Our findings suggest that the ROM after ASE affects PF in male and EV in female patients. This could point to sex-based prevention and rehabilitation after ankle injury.