Miracle-dz/UniFAR-FTUs huggingface dataset:
Considerations on yield, nutrient uptake, cellular growth, and competition in chemostat models

We investigate some properties of a very general model of growth in the chemostat. In the classical models of the chemostat, the function describing cellular growth is assumed to be a constant multiple of the function modeling substrate uptake. The constant of proportionality is called the growth yield constant. Here, this assumption of a constant describing growth yield is relaxed. Instead, we assume that the relationship between uptake and growth might depend on the substrate concentration and hence that the yield is variable. We obtain criteria for the stability of equilibria and for the occurrence of a Hopf bifurcation. In particular, a Hopf bifurcation can occur if the uptake function is unimodal. Then, in this setting, we consider competition in the chemostat for a single substrate, in order to challenge the principle of competitive exclusion. We consider two examples. In the first, the function describing the growth process is monotone and in the second it is unimodal. In both examples, in order to obtain a Hopf bifurcation, one of the competitors is assumed to have a variable yield, and its “uptake” is described by a unimodal function. However, the interpretation is different in each case. We provide a necessary condition for strong coexistence and a sufficient condition that guarantees the extinction of one or more species. We show numerically by means of bifurcation diagrams and simulations, that the competitive exclusion principle can be breached resulting in oscillatory coexistence of more than one species, that competitor-mediated coexistence is possible, and that these simple systems can have very complicated dynamics.
Decrements in Tracking and Visual Performance during Vibration

This literature review specifies the decrements in human performance on tracking and visual acuity tasks during vibration in terms of frequency, acceleration, and direction of vibration. For z-axis (vertical) vibration, which has been studied most extensively, it has been possible to develop tentative equal-decrement curves in terms of frequency and acceleration. For x-axis (longitudinal) and y-axis (lateral) vibration, there are not enough data to do so. The effects of other variables are discussed briefly, and an hypothesis is offered for translating experimental results into predictions of performance decrements for workers in vibration environments.
Subcellular Localization of APE1/Ref-1 in Human Hepatocellular Carcinoma: Possible Prognostic Significance

APE1/Ref-1, normally localized in the nucleus, is a regulator of the cellular response to oxidative stress. Cytoplasmic localization has been observed in several tumors and correlates with a poor prognosis. Because no data are available on liver tumors, we investigated APE1/Ref-1 subcellular localization and its correlation with survival in 47 consecutive patients undergoing hepatocellular carcinoma (HCC) resection. APE1/Ref-1 expression was determined by immunohistochemistry in HCC and surrounding liver cirrhosis (SLC) and compared with normal liver tissue. Survival probability was evaluated using Kaplan-Meier curves (log-rank test) and Cox regression. Cytoplasmic expression of APE1/Ref-1 was significantly higher in HCC than in SLC (P = 0.00001); normal liver showed only nuclear reactivity. Patients with poorly differentiated HCC showed a cytoplasmic expression three times higher than those with well-differentiated HCC (P = 0.03). Cytoplasmic localization was associated with a median survival time shorter than those with negative cytoplasmic reactivity (0.44 compared with 1.64 years, P = 0.003), and multivariable analysis confirmed that cytoplasmic APE1/Ref-1 localization is a predictor of survival. Cytoplasmic expression of APE1/Ref-1 is increased in HCC and is associated with a lower degree of differentiation and a shorter survival time, pointing to the use of the cytoplasmic localization of APE1/Ref-1 as a prognostic marker for HCC.
Relationship of Job involvement with Employee Performance: Moderating role of Attitude

Job involvement was considered very important in the previous literature for increasing the performance ofthe employees. It is hypothesized that involved employees exert considerable efforts for achieving the goalsand objectives of the organization. These kinds of employees are highly productive and produce betterresults as compare to the employees who are not involved with their job. These employees work for theorganization with their hand, head and heart. Several studies examined the relationship of job involvementwith employee performance and claimed that there is a positive relationship between these two variables. Inthis paper we try to further explain the construct of job involvement and combined the results of differentstudies in this context. This paper also tries to explain the controversies between the results of differentstudies and propose to make more construct valid measure for job involvement. Further we alsoconceptualize the relationship of employee attitude in this connection.Keywords: Job involvement, Employee performance, Attitude, Empowerment, Knowledge, Information
Systematic review and meta-analysis of the adolescent HIV continuum of care in South Africa: the Cresting Wave

Context South Africa has the most HIV infections of any country in the world, yet little is known about the adolescent continuum of care from HIV diagnosis through viral suppression. Objective To determine the adolescent HIV continuum of care in South Africa. Data sources We searched PubMed, Google Scholar and online conference proceedings from International AIDS Society (IAS), International AIDS Conference (AIDS) and Conference on Retrovirology and Opportunistic Infections (CROI) from 1 January 2005 to 31 July 2015. Data extraction We selected published literature containing South African cohorts and epidemiological data reporting primary data for youth (15–24 years of age) at any stage of the HIV continuum of care (ie, diagnosis, treatment, retention, viral suppression). For the meta-analysis we used six sources for retention in care and nine for viral suppression. Results Among the estimated 867 283 HIV-infected youth from 15 to 24 years old in South Africa in 2013, 14% accessed antiretroviral therapy (ART). Of those on therapy, ∼83% were retained in care and 81% were virally suppressed. Overall, we estimate that 10% of HIV-infected youth in South Africa in 2013 were virally suppressed. Limitations This analysis relies on published data from large mostly urban South Africa cohorts limiting the generalisability to all adolescents. Conclusions Despite a large increase in ART programmes in South Africa that have relatively high retention rates and viral suppression rates among HIV-infected youth, only a small percentage are virally suppressed, largely due to low numbers of adolescents and young adults accessing ART.
Determination of the CFL number for FD-ADI-FDTD based on the required accuracy

Ultra wideband (UWB) systems have a wide range of applications from microwave imaging to communication purposes. Major advances towards the realization of these applications require a system modeling which produces UWB signal waveforms after propagation in a lossy media. The frequency dependent (FD) finite difference lime domain (FDTD) method is a popular method to do so but is faced with the Courant-Friedrichs-Levy (CFL) condition which limits its time discretisation size. The alternating direction implicit (ADI) method has been introduced to FDTD to remove that CFL condition. This paper has novelty in quantification of the contribution of the spatial discretisation on error of FD-ADI-FDT and, based on this result, in proposing the scheme to determine the temporal and spatial discretisation from the viewpoint of accuracy
Painful peripheral neuropathy and its nonsurgical treatment

Treatment of neuropathic pain is the primary focus of management for many patients with painful peripheral neuropathy. Antidepressants and anticonvulsants are the two pharmacological classes most widely studied and represent first‐line agents in the management of neuropathic pain. The number of pharmacological agents that have demonstrated effectiveness for neuropathic pain continues to expand. In the current review, we summarize data from randomized, controlled pharmacological trials in painful peripheral neuropathies. Although neuropathic pain management remains challenging because the response to therapy varies considerably between patients, and pain relief is rarely complete, a majority of patients can benefit from monotherapy using a well‐chosen agent or polypharmacy that combines medications with different mechanisms of action. Muscle Nerve 30: 3–19, 2004
Guidelines for catheter intervention in coronary artery lesion in Kawasaki disease

Abstract The Research Committee of Ministry of Health, Labour and Welfare ‘Study of treatment and long‐term management in Kawasaki disease’ reported the guidelines for catheter intervention in coronary artery lesion in Kawasaki disease in this paper. The contents include: (i) background and natural history of coronary artery lesion in Kawasaki disease; (ii) indication of catheter intervention; (iii) types of procedure, and their indication and care; (iv) institute and backup system; (v) the management after procedure, evaluation and follow up; and (vi) prospects, especially in relation to bypass surgery.
Evaluation of Five Enzyme Immunoassays Compared with the Cytotoxicity Assay for Diagnosis of Clostridium Difficile-Associated Diarrhea in Dogs

Clostridium difficile-associated-diarrhea (CDAD) is a nosocomial infection in dogs. Diagnosis of this infection is dependent on clinical signs of disease supported by laboratory detection of C. difficile toxins A or B, or both, in fecal specimens via enzyme-linked immunosorbent assay (ELISA). Unfortunately, to the authors' knowledge, commercially available ELISAs have not been validated in dogs to date. We evaluated 5 ELISAs done on 143 canine fecal specimens (100 diarrheic and 43 nondiarrheic dogs) and on 29 C. difficile isolates. The results of each ELISA were compared with the cytotoxin B tissue culture assay (CTA). Clostridium difficile was isolated from 23% of the fecal specimens. Eighteen of the 143 fecal specimens were toxin positive (15 diarrheic and 3 nondiarrheic dogs). On the basis of multiplex polymerase chain reaction (PCR) analysis for toxin-A and -B genes, 72% of the isolates were toxigenic. The carriage rate of toxigenic isolates in diarrheic dogs was higher than that in the nondiarrheic dogs; however, these differences were not statistically significant. A good correlation was found between CTA, PCR, and culture results. The ELISAs done on fecal specimens collected from diarrheic dogs had low sensitivity (7–33%). In contrast, ELISA for toxin A or B, or both, performed on toxigenic isolates had high sensitivity (93%). These results suggest that commercially available human ELISAs are inadequate for the diagnosis of canine C. difficile-associated diarrhea when tested on fecal specimens. In contrast, the Premier ToxinA/B and Techlab ToxinA/B ELISAs may be useful for the diagnosis of canine CDAD when used on toxigenic isolates.
Sensitivity Analyses for Ecological Regression

Summary. In many ecological regression studies investigating associations between environmental exposures and health outcomes, the observed relative risks are in the range 1.0–2.0. The interpretation of such small relative risks is difficult due to a variety of biases—some of which are unique to ecological data, since they arise from within‐area variability in exposures/confounders. The potential for residual spatial dependence, due to unmeasured confounders and/or data anomalies with spatial structure, must also be considered, though it often will be of secondary importance when compared to the likely effects of unmeasured confounding and within‐area variability in exposures/confounders. Methods for addressing sensitivity to these issues are described, along with an approach for assessing the implications of spatial dependence. An ecological study of the association between myocardial infarction and magnesium is critically reevaluated to determine potential sources of bias. It is argued that the sophistication of the statistical analysis should not outweigh the quality of the data, and that finessing models for spatial dependence will often not be merited in the context of ecological regression.
Regional infusions of serotonin into the striatum and memory consolidation

Lesions, temporal inactivation, electrical stimulation and administration of drugs that antagonize synaptic activity of the striatum lead to significant deficits of memory. Also, it has been shown that interruption of dopaminergic, GABAergic, or cholinergic activity in discrete areas of this structure is sufficient to disrupt cognitive functions. In spite of the known interactions among dopamine, GABA, acetylcholine, and serotonin, there is a notable scarcity of data germane to the participation of striatal serotonin in learning and memory. It was important, therefore, to investigate the possible involvement of serotonin in cognition. In light of the differential distribution of serotonergic elements within the striatum, a prediction was made that focal injections of serotonin into distinctive regions would produce dissimilar effects on memory. Rats were trained in a one‐trial step‐through inhibitory avoidance task and a retention test was carried out 24 h later. Posttraining injections of serotonin into the dorsal and ventral aspects of the posterior region produced strong amnesia compared to similar injections into the dorsal and ventral aspects of the anterior region. The present findings support the hypothesis that striatal serotonergic activity is involved in memory functions and also provide further evidence of neurochemical heterogeneity within the striatum regarding memory consolidation. Synapse 47:169–175, 2003. © 2002 Wiley‐Liss, Inc.
Cellular telephones and risk for brain tumors

Objective: To evaluate a possible association of glioma or meningioma with use of cellular telephones, using a nationwide population-based case-control study of incident cases of meningioma and glioma. Methods: The authors ascertained all incident cases of glioma and meningioma diagnosed in Denmark between September 1, 2000, and August 31, 2002. They enrolled 252 persons with glioma and 175 persons with meningioma aged 20 to 69. The authors also enrolled 822 randomly sampled, population-based controls matched for age and sex. Information was obtained from personal interviews, medical records containing diagnoses, and the results of radiologic examinations. For a small number of cases and controls, the authors obtained the numbers of incoming and outgoing calls. They evaluated the memory of the respondents with the Mini-Mental State Examination and obtained data on socioeconomic factors from Statistics Denmark. Results: There were no material socioeconomic differences between cases and controls or participants and non-participants. Use of cellular telephone was associated with a low risk for high-grade glioma (OR, 0.58; 95% CI, 0.37 to 0.90). The risk estimates were closer to unity for low-grade glioma (1.08; 0.58 to 2.00) and meningioma (1.00; 0.54 to 1.28). Conclusion: The results do not support an association between use of cellular telephones and risk for glioma or meningioma.
An Open-Label, Randomized Trial of Methylphenidate and Atomoxetine Treatment in Adults With ADHD

Objective: To directly compare the efficacy of methylphenidate and atomoxetine in improving symptoms, social functions, and quality of life among adults with ADHD. Method: This was an 8-to-10-week, open-label, head-to-head, randomized clinical trial with two treatment arms: immediate-release methylphenidate (IR-methylphenidate; n = 31) and atomoxetine once daily (n = 32). The outcome measures included ADHD symptom severity, quality of life, and functional impairments. Results: We found a significant reduction in overall ADHD symptoms and improvement in social functions and quality of life for both groups at Weeks 4 to 5 and Weeks 8 to 10. There was no significant difference in the slope of improvements over time except that atomoxetine was superior to IR-methylphenidate in reducing hyperactive/impulsive symptoms at Weeks 4 to 5. There was no significant group difference in the rates of adverse effects. Conclusion: Both IR-methylphenidate and atomoxetine are well tolerated and efficacious in ethnic Chinese adults with ADHD.
Observations of coupled spheroidal and toroidal modes

In low-frequency seismic spectra the Coriolis force theoretically causes quasi-degenerate coupling of spheroidal and toroidal modes whose spherical harmonic degrees differ by unity and whose frequencies are close. It has been found that the coupling causes clearly observable effects on seismic spectra below 3.0 mHz. Many fundamental toroidal modes have a spheroidal component and vice versa. For example, the 0Sl modes for l = 8–22 are significantly coupled to the 0Tl modes for l = 9–23. The mean frequencies of pairs of coupled multiplets are repelled, and the mean attenuations are averaged. The shifting of complex frequencies must be adequately encompassed in the construction of spherically averaged and aspherical models of the density and elastic and anelastic structure of the earth. The coupling also causes variations in multiplet amplitudes which result in spectral peaks at toroidal mode frequencies on vertical and radial components and at spheroidal mode frequencies on transverse components. The variations must be taken into account in constructing Green's functions for the study of low-frequency source mechanisms.
An Investigation of Visual Responses to Brief Stereoscopic Stimuli

An analytic model of the temporal properties of visual responses to brief stimuli is described. The model is based on the notion that visual responses persist for some time after the occurrence of brief stimuli. The model is quantified from data on stereopsis obtained with alternating brief monocular presentations of disparate stimuli. The relevance of the analysis for the data of experiments using tachistiscopic techniques is discussed.
Program Change and Organizational Properties a Comparative Analysis

Empirical indicators of the organizational properties of complexity, centralization, formalization, and morale are developed and related to the rate of adoption of new programs and services in sixteen social welfare organizations. Specifically, a high deree of participation in agency-wide decisions, a low deree of job condification, and a high degree of job satisfactions are found to be most highly associated with a high rate of program change. Measures of staff attitudes toward change are forund to be only weakly and inversely to the rate of innovation of new programs and techniques. The relationships between organizational properties and rate of program change largely remained when size, auspices, age of oranization and function were controlled. The distinction between rate of program change and changes in decision making, job codification, and job satisfaction allows us to discuss changes within a system and changes of a system of organizational properties.
Cetacean Morbillivirus in Coastal Indo-Pacific Bottlenose Dolphins, Western Australia

Cetacean morbillivirus (CeMV) has caused several epizootics in multiple species of cetaceans globally and is an emerging disease among cetaceans in Australia. We detected CeMV in 2 stranded coastal Indo-Pacific bottlenose dolphins (Tursiops aduncus) in Western Australia. Preliminary phylogenetic data suggest that this virus variant is divergent from known strains.
Children of Parapartum Mentally Ill Mothers: A Follow-Up Study

A 2-year cohort of children (n = 75) of hospitalised first-episode parapartum mentally ill mothers in the mid-1970s in Stockholm were studied. The children were followed up during the school-age period from 1982 through 1992, and they were studied with regard to health development, academic achievement and family situation. Comparisons were made with matched controls. Data were collected from hospital case notes, the local tax authorities and school reports. No significant differences were found between the index children and the controls regarding the number of inpatient care episodes or days of inpatient care during the follow-up period. Nor was any significant difference found between the index and the control children regarding academic achievement as measured by the mean of all marks. Four index children and 2 controls were studying in schools for the mentally retarded. Seventy-four percent of the children of the patients were living with their mother, compared to 95% of the controls (p < 0.001). In conclusion, the children of mentally ill mothers in this longitudinal study did as well as the controls. The reason might be the social support provided by society (when needed) for these high-risk families in Sweden.
Liver transplantation for acute liver failure due to efavirenz hepatotoxicity: the importance of routine monitoring

We present the first case report in the UK of acute liver failure caused by efavirenz therapy culminating in liver transplantation. A 26-year-old Zimbabwean woman commenced emtricitabine, tenofovir and efavirenz (Atripla) in December 2011. Her liver function tests at baseline and at 20 days after initiating antiretroviral therapy were normal. At three months of therapy her blood tests haemolysed and were not processed. She had previously missed follow-up appointments and on this occasion failed to return for repeat tests. She was not seen again until after six months of antiretroviral therapy when she presented to her general practitioner with acute liver failure. Her condition deteriorated and she required liver transplantation. She recovered well and re-started antiretroviral therapy to good effect. The case illustrates the value of routine monitoring after initiating antiretroviral therapy and the fundamental importance of engaging patients in long-term management to ensure safe treatment.
Positioning occupational therapy as a discipline on the research continuum: results of a cross-sectional survey of research experience.

BACKGROUND/AIM Evidence-based practice and research are beginning and endpoints on a research continuum. Progression along the continuum builds research capacity. Occupational Therapy has a low evidence base, thus, clinicians are not implementing evidence-based practice or publishing research. Barriers to implementing evidence-based practice and engaging in research include a lack of confidence. This research gauged Occupational Therapists' research experience, support needs and barriers, and compared levels of research anxiety between allied health disciplines. METHODS A cross-sectional survey was sent to Health Practitioners in northern Queensland in May-June 2011. Responses about experience, support needs and barriers, between Occupational Therapists, were analysed using Chi-square 'goodness of fit' tests. Multivariate analysis compared responses between disciplines about research anxiety. This paper reports results for the subset of Occupational Therapists. RESULTS The whole population, consisting of 152 Occupational Therapists, was sent a questionnaire, from which 86 responded. More Occupational Therapists than not had experience of evidence-based practice and less support was required, but they had little experience of producing research and required more support. The amount of support required for activities along the research continuum was inversely related to the level of experience in these tasks. Barriers included lack of staff and time. Occupational Therapists were more anxious about research (53 of 79, 67%) than all other Health Practitioner disciplines combined (170 of 438, 39%, P < 0.0001). CONCLUSION A cohesive strategy should focus on consolidating Occupational Therapists' evidence-based practice skills and building confidence. Clinicians wishing to engage in research need access to academic support. Academics and clinicians should work closely to produce clinically relevant research.