Miracle-dz/UniFAR-FTUs huggingface dataset:
Exercise and the cAMP system in rat adipose tissue. I. Lipid mobilization.

Protein kinase (PK) and hormone-sensitive lipase (HSL) were measured at rest in adipose tissue of untrained male rats and in that of animals subjected to a strenuous program of treadmill running. Total amounts of PK activity (decreased from 860 +/- 104 to 474 +/- 53 pmol.min-1. (10(6) cells)-1 (P less than 0.01) as a result of exercise training. At the same time, binding capacity for adenosine 3',5'-cyclic monophosphate (cAMP) was elevated in the runners. These data suggest a functional loss in catalytic activity without a loss in binding capacity. In addition, the results provide evidence that the capacity of PK to activate HSL is reduced in adipocytes of physically trained rats. HSL activity was measured in both adipose tissue slices and isolated adipocytes. The results show that the levels of activity of HSL did not increase as a result of the running program. These results provide evidence that the lipolytic capacity of adipocytes of normal untrained male rats is sufficiently large to meet the increased demand for free fatty acids imposed by the exercise program without the need for an adaptive increase in HSL activity.
In Their Own Hands: How Savings Groups Are Revolutionizing Development

Two and a half billion people worldwide, most of them desperately poor villagers, need a better way to save and to borrow. Even the most innovative banking institutions can’t reach them; savings groups can. In savings groups, members save what they can in a communal pot and loan their growing fund to each other for their short-term needs. Jeffrey Ashe and Kyla Neilan illustrate how these savings groups form and function and how little “outside” support is actually required for their success. Drawing on decades of Ashe’s personal experience, this book describes how he developed Saving for Change, which leveraged the wisdom and strength of group members to train and establish new groups. This model has impacted the lives of 680,000 people across five countries. Savings groups are a “catalytic innovation” that bypasses subsidies, dependency, and high costs while effectively reducing chronic hunger, building assets, and empowering the community. Today, saving groups have 9 million members around the globe—with minimal support, membership could grow to ten times this number.
Heterogeneous Intermediaries and Asset Prices

Canonical intermediary asset pricing models assume a representative intermediary with an SDF linear in its leverage. Yet the leverage of broker-dealers is procyclical whereas the leverage of banking holding companies is countercyclical. I propose an empirically testable heterogeneous intermediary stochastic discount factor (HI-SDF) that depends non-linearly on aggregate leverage as well as net worth shares of individual intermediaries. I show that the HI-SDF emerges from general equilibrium models with heterogeneous intermediaries whereas its specific functional form hinges on different models' specifications of financing constraints. To address this issue, the HI-SDF is estimated semiparametrically. I provide empirical evidence that the wealth distribution among intermediaries is an important source of risk for pricing risky securities. The estimated HI-SDF is found to exhibit substantial explanatory power for cross-sectional variation in expected returns across a wide range of test assets. In contrast to representative intermediary empirical models, the HI-SDF exhibits lower pricing errors and explains larger fractions of the cross-section of expected returns.
Exhaled Nitric Oxide Decreases during Academic Examination Stress in Asthma.

RATIONALE Fractional exhaled nitric oxide (FeNO) is known to vary with multiple endogenous and exogenous factors. Laboratory stress and depressive mood have been associated with altered FeNO levels, but little is known about the susceptibility of FeNO to longer-lasting states of psychological stress in asthma. OBJECTIVES We sought to study changes in FeNO, lung function, and endogenous cortisol levels in students in a low-stress period during the academic term and in high-stress periods of up to 5 days during final exams. METHODS One hundred nine participants (35 with asthma) enrolled in a final examination stress study were assessed during the academic term (low stress) and during final exams (high stress). FeNO, spirometric lung function (FEV1, peak flow), salivary cortisol, and negative affect were measured at three time points. Control variables were medication use, cold symptoms, sex, and age. MEASUREMENTS AND MAIN RESULTS FeNO decreased substantially from low-stress baseline to the high-stress examination periods, with more pronounced decreases occurring in subjects with asthma (-11.5 ppb) than control subjects (-1.2 ppb). FEV1 decreased in both groups. Negative affect and cortisol increased during final exams, but these increases were smaller in asthma. Greater initial depression and greater cortisol increases were related to larger FeNO decreases during the final exam period, the latter only in asthma. Inhaled corticosteroid use did not affect these changes. CONCLUSIONS Psychological stress and depressive mood are accompanied by decreases in both FeNO and lung function in asthma. Fluctuations related to life stress and mood levels should be considered in FeNO monitoring for asthma.
Serum uric acid: not a discriminator of coronary heart disease in men and women.

Fasting serum uric acid (SUA) was measured using a spectrophotometric method in 635 randomized male subjects aged 20 to 70, as part of an epidemiological study carried our among the civil employees of French origin working for the City of Montreal. It was observed that SUA was not age-dependent and that the overall mean value was 6.26 mg. /100 ml. On the other hand SUA was studied in 742 males and 260 females, all of whom had had coronarography. A significant difference in SUA between males and females of 1.26 mg. /100 ml. was noted. Correlating the SUA levels with the incidence of CHD or the severity of the lesions in the coronary arteries indicated no relationship between CHD and SUA concentrations in men or in women. The results of this study permit the conclusion that SUA is not a discriminator for CHD.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI TERJADINYA FINANCIAL STATEMENT FRAUD: PERSPEKTIF DIAMOND FRAUD THEORY (Studi Pada Perusahaan Perbankan Yang Terdaftar Di Bursa Efek Indonesia Periode 2014-2016)

This study aimed to analyze the factors that encourage financial statement fraud with analysis of diamond fraud theory. This research analyzes the influence of variable pressure proxied by financial targets, financial stability, external pressure, personal financial need, the opportunity proxied by nature of industry, ineffective monitoring, razionalization proxied by audit opinion, and the capability to replace any directors proxies against financial statements fraud. The sample in this research are 105 samples of banking companies listed on Indonesia Stock Exchange in the period 2014-2016. The results showed that the variable of financial targets as measured by return on asset, external pressure as measured by the leverage ratio, personal financial need as measured by the ownership of shares by the board of commission influence the financial statements fraud. The study did not found financial stability pressures as measured by the ratio of change total asset, ineffective monitoring as measured by the ratio of affiliated commissioner, nature of industry as measured by the ratio of change receivables, the audit opinion as measured by obtaining unqualified opinion with explanatory language, and capability as measured by changes of directors influence on fraudulent financial statements.
Relationship between multiple CRM activities in retail and customer performance: The moderating effects of brand loyalty and variety seeking behavior

This study examines the effect of selective promotion and assortment based on customer relationship management (CRM) data as well as reward points on share of wallet (SOW), expenditure, and customer satisfaction, coupled with the moderating effects of customers’ brand loyalty and variety-seeking behavior in retail. This study adopts a two-stage, multi-method research design using a qualitative study followed by a quantitative study to construct a theoretical framework on the hypotheses. The results show that reward points directly enhance SOW whereas assortment based on CRM enhances customer satisfaction. Additionally, the effect on expenditure by reward points is strengthened by brand loyalty, whereas selective promotion is strengthened by variety-seeking behavior. Although existing research indicates the CRM effect that leads to effective communication with customers and more efficient merchandising, previous research mainly examined the effect of CRM implementation or reward points. Therefore, the difference between the effect of reward points and other CRM activities remains unclear. This study verifies the different effects of multiple CRM activities in retail, identifies brand loyalty and variety-seeking behavior as original contingent factors of CRM, and verifies their influence on respective CRM activities.
Demography factors, financial risk tolerance, and retail investors

This study aims to understand the influence of demography factors, as an independent variable to the financial risk tolerance of retail investors who conduct stock investment transactions on the Indonesia Stock Exchange, as a dependent variable. The research used a quantitative approach to binary logistic regression analysis model and online questionnaire method for the data collection. The questionnaires were distributed through online media and communication tools, including the mailing list and social media. The number of observed respondents which met the criteria were about 162 respondents. Then, the parametric study showed a significant positive partial effect from the independent variable, income, against dependent variable financial risk tolerance. The other independent variables consisted of gender, age, marital status, education, and occupation; did not exhibit any significant impact on financial risk tolerance
Freedom and the “choice to choose oneself” in being and time

© Cambridge University Press 2013. What Heidegger means by “freedom” in Being and Time is somewhat mysterious: while the notion crops up repeatedly in the book, there is no dedicated section or study, and the concept is repeatedly connected to a new and opaque idea – that of the “choice to choose oneself. ” Yet the specificity of Being and Time’s approach to freedom becomes apparent when the book is compared to other texts of the same period, in particular The Metaphysical Foundations of Logic, The Fundamental Concepts of Metaphysics, The Essence of Grounds, and The Essence of Freedom. Although there are some differences, the definition of freedom that can be found there identifies it with “existence” or “transcendence,” Dasein’s ek-static opening onto the world. Thus “being in the world must also be primordially bound up with or derived from the basic feature of Dasein’s existence, freedom… Dasein’s transcendence and freedom are identical! Freedom provides itself with intrinsic possibility: a being is, as free, necessarily in itself transcending” (GA 26: 238; Heidegger’s italics). Note the apodictic modality of the claim: it is not simply the case that Dasein, as transcending, is free. Anything that has the structure of being in the world must be free: freedom is co-extensive with Dasein. Yet Dasein is often pictured in Being and Time as anything but free: it “ensnares itself” (268), is “lost” (264), “alienated” (178), and needs to be “liberated” (264, 303). Thus comparison between Being and Time and other texts on freedom yields an important paradox: although by definition it transcends toward the world, the Dasein of Division I is deprived of freedom. It must be free, and yet phenomenological analysis shows that it is not free. To understand the specific meaning of freedom in Being and Time, one has to square this circle.
The SPDC and Challenges of Corporate Social Responsibility : Evidence from the Niger Delta Region, Nigeria

The Niger Delta Region of Nigeria produces a significant portion of the aggregate oil wealth of Nigeria. Since 1956 when oil was first struck in Oloibiri in Southern Nigeria, the Niger Delta region has accounted for over 90 per cent of Nigeria’s oil income. However, the region has perennially suffered from environmental neglect, crumbling infrastructures and services, high unemployment, social deprivation, abject poverty and endemic conflict. This has led to calls for oil companies operating in the Niger Delta to demonstrate the value of their investments to Nigeria by undertaking increased community development initiatives that provide direct social benefits such as local employment, new infrastructure, schools, and improved health care delivery. This paper examines the concept of Corporate Social Responsibility (CSR) that is, how companies manage their oil exploration and business processes to produce an overall positive impact on society. It has focused on the impact of Corporate Social Responsibilities (CSR) on oil producing communities using Shell Petroleum Development Company of Nigeria (SPDC) as a case study. This is considered the thrust of this study that assessed the extent, constraints and challenges to the adoption of the principles of corporate social responsibility by SPDC; to operate in the Niger Delta fully according to robust international social and environmental standards. It concludes that SPDC should adopt a reformed approach to improve operational transparency and a bottom-up community led approach to development programmes in the Niger Delta region.
A proposed study on the use of ICT and smart meters to influence consumers' behavior and attitude towards Renewable Energy

Recently, use of Renewable Energy (RE) and development of RE technologies are being promoted by many countries. Policies have also been developed to facilitate and encourage consumers to adopt RE. However, the availability of technologies alone does not guarantee their widespread adoption. Numerous reports have identified the barriers are due to lack of knowledge and awareness towards the new technologies. This paper proposes a study and the development of an Information and Communication Technology (ICT) learning tool incorporating the use of smart meters in order to provide knowledge, increase awareness and to influence consumers' behavior and attitude in adopting RE. This proposed research is based on quantitative and qualitative approach and the study will be carried out among residents from a local council in Western Australia. It is expected that results from this study will provide insights and understanding to encourage RE adoption through the use of ICT and smart meters.
The ForeSeeHome device and the HOME study: a milestone in the self-detection of neovascular age-related macular degeneration.

detection methods that register, quantify, and compare macular dysfunction over time have not been available. Ideally, an instrument that would integrate these features could be developed. The Home Monitoring of the Eye (HOME) study is a culmination of such an effort. 5 The HOME study determined whether CNV from AMD could be detected earlier using telemonitoring and preferential hyperacuity perimetry, a technique of macular visual field testing that can exceed the sensitivity of
Methodological and Design Issues in Clinical Trials of New Neuroleptics: an Overview

The recent development of new neuroleptics that differ from the conventional neuroleptics in both mechanism of action and side-effects profile has introduced problems in their clinical assessment, and highlighted ongoing issues in the design and methodology of clinical trials. These issues are broadly grouped and discussed as follows: sampling problems and selection of patients; design issues; problems in measurement; ensuring compliance; recognition of extrapharmacological issues; and statistical models. For patients to benefit from the development of new neuroleptics, clinical settings have to be prepared for testing their efficacy and safety without too much delay in well designed clinical trials.
Sensitivity to triazolam in the elderly.

BACKGROUND Elderly persons frequently appear to be sensitive to the effects of many drugs that depress the central nervous system. We studied the effect of age on the pharmacokinetics and pharmacodynamics of the benzodiazepine hypnotic agent triazolam, now the most frequently prescribed hypnotic drug in the United States. METHODS Twenty-six healthy young subjects (mean age, 30 years) and 21 healthy elderly subjects (mean age, 69 years) participated in a four-way crossover study. After a single-blind adaptation trial with placebo, each subject received, in random order and in double-blind fashion, single doses of placebo, 0.125 mg of triazolam, and 0.25 mg of triazolam. For 24 hours after the administration of each of the three study medications, plasma triazolam levels were determined and psychomotor performance, memory, and degree of sedation were assessed. RESULTS Plasma triazolam concentrations increased in proportion to the dose, but the elderly subjects had higher plasma concentrations due to reduced clearance of the drug. The degree of sedation as rated by an observer and the reduction in the subjects' performance on the digit-symbol substitution test were both greater in the elderly than in the young subjects after they were given the same doses. The relation of the plasma triazolam concentration to the degree of impairment was similar for the two groups. As part of the study, information was presented 1 1/2 hours after the administration of the drugs; the subjects' ability to recall the information 24 hours later was impaired by both doses of triazolam, and the percent decrease was similar in the young and elderly groups. CONCLUSIONS Triazolam caused a greater degree of sedation and greater impairment of psychomotor performance in healthy elderly persons than in young persons who received the same dose. These effects resulted from reduced clearance and higher plasma concentrations of triazolam rather than from an increased intrinsic sensitivity to the drug. On the basis of these results, the dosage of triazolam for elderly persons should be reduced on average by 50 percent.
The impact of Organizational Justice and Demographic on Faculty Retention in Bahrain

Aim – Employee retention is a major issue for organizations across the board. There is a great influence on this aspect for organizations to retain qualified people in the organizations. The present research study aimed to examine the role and impact of organizational justice and personal demographic characteristics on the employee retention in the academics. Therein, the focus of the study was on the faculty members working in the private universities in the kingdom of Bahrain. Research Design & Methodology – Quantitative approach was found to be appropriate to target the faculty members across the five private universities in Kingdom of Bahrain. A total of 207 faculty members working in five major private universities were sampled for the present study through using email as a major source for its distribution and reaching out to target respondents. Results - The statistical results found significant positive relationship between organizational justice aspects including distributive justice, procedural justice and procedural justice with faculty retention across the private universities in Bahrain. Accordingly, the study also reported significant correlation between personal demographic characteristics and faculty retention. The findings hence have reported noteworthy results for all the hypothesized relationships of the present study. Conclusions - The study found importance of organizational justice and personal demographic characteristics towards enhancing faculty members` retention. The study outlines details about different organizational justice prospects and how they can be responsively capitalized by universities and institutions in the higher education sector to assure employee retention. The study has forwarded theoretical and practical implications based on the results that can be of considerable significance for higher education institutions to retain employees.
Self-administration of romiplostim in patients with chronic immune

Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City; New York Presbyterian Hospital, Departments of Pediatrics and Medicine, Division of Hematology, New York; Cancer Care Centers of South Texas/ US Oncology, San Antonio, Texas; 4 Jane Ann Nohl, Division of Hematology, University of Southern California Keck School of Medicine, Los Angeles; University of Pittsburgh (Pennsylvania) Cancer Institute; Department of Hematology, AZ Sint-Jan Brugge-Oostende, Brugge, Belgium; Amgen Inc, Thousand Oaks, California
Shyness and Cognitions: An Examination of Turkish University Students

The authors aimed to examine the relation between shyness and dysfunctional relationship beliefs and to extend findings of previous studies to understand the role of fear of negative evaluation and self-esteem in shyness. Participants were 415 Turkish undergraduate students at Middle East Technical University. The participants completed Turkish versions of the J. M. Cheek and A. H. Buss (1981) Shyness Scale, the Interpersonal Cognitive Distortions Scale (Z. Hamamci & S. Büyüköztürk, 2004) the Brief Fear of Negative Evaluation Scale (M. R. Leary, 1983), and the M. Rosenberg (1965) Self-Esteem Scale. Bivariate correlations showed that shyness had a significant positive correlation with unrealistic relationship expectations and interpersonal rejection. Fear of negative evaluation and self-esteem also had significant relations to shyness. A stepwise regression analysis indicated that fear of negative evaluation, self-esteem, and interpersonal rejection were significant predictors of shyness, and self-esteem was the best predictor. These results provided evidence of the role of distorted relationship beliefs, approval concerns, and self-evaluations in shyness for Turkish university students. The authors discuss the findings in terms of relevant literature and cultural issues.
Plant responses to CO2: background and perspectives.

Ichiro Terashima*, Shuichi Yanagisawa and Hitoshi Sakakibara Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan Biotechnology Research Center, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan Riken Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan *Corresponding author: E-mail, itera@biol.s. u-tokyo.ac. jp; Fax: +81-3-5841-4465
Absorption kinetics of aspirin in man following oral administration of an aqueous solution.

The absorption of aspirin was studied in four male subjects following an oral solution of 650 mg. The absorption process appeared to follow first-order kinetics, with a half-life ranging from 4.5 to 16.0 min. between subjects. Comparison of the area under the aspirin plasma concentration-time curve following intravenous and oral routes indicated that only 68% of the dose reached the peripheral circulation intact. A two-compartment model for both aspirin and its metabolite, salicylic acid, involving a constant fractional hydrolysis of aspirin during absorption, satisfactorily described both the aspirin and resultant salicylic acid plasma data. Methods used to calculate aspirin absorption kinetics are discussed.