Miracle-dz/UniFAR-FTUs huggingface dataset:
Galietta Channels −-Dependent Cl 2 + TMEM 16 A Protein : A New Identity for Ca

[PDF] [Full Text] [Abstract] , January 15, 2014; 306 (2): H163-H172. Am J Physiol Heart Circ Physiol John J. Reho, Xiaoxu Zheng and Steven A. Fisher Smooth muscle contractile diversity in the control of regional circulations [PDF] [Full Text] [Abstract] , June 1, 2014; 25 (11): 1793-1807. Mol. Biol. Cell Chelsey Chandler Ruppersburg and H. Criss Hartzell channel ANO1/TMEM16A regulates primary ciliogenesis − -activated Cl 2+ The Ca [PDF] [Full Text] [Abstract] , July 1, 2014; 217 (13): 2288-2296. J Exp Biol Julia E. Herr, Alexander M. Clifford, Greg G. Goss and Douglas S. Fudge swelling of released mucin vesicles and aquaporin-mediated 2+ Defensive slime formation in Pacific hagfish requires Ca [PDF] [Full Text] [Abstract] , December 15, 2014; 307 (12): C1102-C1112. Am J Physiol Cell Physiol Dumont, L. J. Galietta, A. Boom and V. Kruys L. Twyffels, A. Strickaert, M. Virreira, C. Massart, J. Van Sande, C. Wauquier, R. Beauwens, J. E. Anoctamin-1/TMEM16A is the major apical iodide channel of the thyrocyte [PDF] [Full Text] [Abstract] , December 23, 2014; 111 (51): 18213-18218. PNAS Tingting Yang, Wayne A. Hendrickson and Henry M. Colecraft channels − -gated Cl 2+ inactivation of TMEM16A/16B Ca -dependent sensitization of activation and 2+ Preassociated apocalmodulin mediates Ca
Cumulative Impact Factor : 45 . 07 TESTING THE EXPORT-LED GROWTH PARADIGM THROUGH ECONOMETRIC METHODS : EMPIRICAL EVIDENCE FROM NAMIBIA OGBOKOR

Despite the large volume of documented empirical studies in the existing literature concerning the export-led model in the last four decades, the exact connection between exports and economic growth remains largely unanswered. Indeed, both theoretical and empirical inquiries are still seeking for definite answers. Accordingly, this study employs the VAR technique to empirically assess the applicability of the export-led growth model in the context of Namibia through the help of quarterly time-series data-sets for the period covering 1990 to 2012. In this regard, the study tested for the existence of a long-run relationship between exports and economic growth. The results of the unit root test indicated that, foreign direct investment and exchange rate variables attained a stationary status in levels, while real gross domestic product and exports only became stationary after first differencing. The cointegration test suggests a stable long-run relationship among the variables used in the VAR specification. The Granger-causality test found a unidirectional relationship running from exports to economic growth. Therefore, the study recommends that trade policies which encourages export expansion should be aggressively pursuit by the government of Namibia, while simultaneously striving towards improving upon the competiveness of its exports in foreign markets.
Discovery of BCL-2 as an Oncogene and the First Inhibitor of Apoptosis

Mutations that impair apoptosis contribute to cancer development and reduce the effectiveness of conventional anti-cancer therapies. These insights and understanding of how the B cell lymphoma (BCL)-2 protein family governs apoptosis have galvanized the search for a new class of cancer drugs that target its pro-survival members by mimicking their natural antagonists, the BCL2 homology (BH)3-only proteins. Successful initial clinical trials of the BH3 mimetic venetoclax/ABT-199, specific for BCL-2, have led to its recent licensing for refractory chronic lymphocytic leukemia and to multiple ongoing trials for other malignancies. Moreover, preclinical studies herald the potential of emerging BH3 mimetics targeting other BCL-2 pro-survival members, particularly myeloid cell leukemia (MCL)-1, for multiple cancer types. Thus, BH3 mimetics seem destined to become powerful new weapons in the arsenal against cancer. This review sketches the discovery of the BCL-2 family and its impact on cancer development and therapy; describes how interactions of family members trigger apoptosis; outlines the development of BH3 mimetic drugs; and discusses their potential to advance cancer therapy.
Forming the low­porous layers of indium phosphide with the predefined quality level

The morphological quality criterion was developed to have a possibility of formation of nanostructured layers on semiconductor surface with adjustable properties. The layers of low-porous indium phosphide with mesoporous structure were obtained. The porous layers were formed by the method of electrochemical etching in the solution of hydrochloric acid at constant current density. According to the developed criterion, the quality of synthesized por-InP samples was analyzed. This will make it possible to manufacture the structures with porous layers on the surface on an industrial scale. The presented criterion can be applied to other modes of treatment of indium phosphide or to other semiconductors. This will make it possible to treat it as a universal morphological criterion of quality of porous structures. The correlation between morphological properties of porous structures on the surface of indium phosphide and etching conditions was established. To do this, porous structures, which were formed in the interval of etching time from 10 to 20 min at different concentration of acid in the electrolyte, were analyzed. As a result, it was established that the shape of the pores of nanostructured layers on the surface of semiconductors depends not only on parameters of a crystal, but also on etching conditions, specifically, on etching time and electrolyte composition. The application of saturated electrolytes leads to formation of massive groove-shaped pores – elongated ellipses. The obtained correlations are useful from the practical point of view, as they make it possible to approach reasonably determining the modes of electrochemical treatment of semiconductors. In addition, it opens up new prospects in the construction of the model of self-organization of a porous structure on the surface of semiconductors. The technique of calculating basic statistical characteristics of the series of distribution of pores by dimensions, specifically, the variation span, dispersion, mean deviation, coefficients of variation and asymmetry was presented. This makes it possible to evaluate in detail the morphological indicators of porous structures and to progress in understanding the mechanisms behind the pore formation on the surface of semiconductors during electrochemical treatment.
Study on Adoption of Eco-Friendly Management Practices by Vegetable Growers in Indore Block of Indore District (M.P.)

The development of India is depending on agriculture and it is engaging about 70 per cent of its population directly or indirectly. It contributes nearly 37 per cent of the net national product and account for a sizable share of total value of the country's export. The present rate of agriculture production could be doubled if the available technology is appropriately transferred to the farmers for its adoption. It is however reported that not more than 30 to 40 per cent of the technologies have gone to the farming communities so far, even though there is strong network of extension mechanism operating for accelerating agriculture production. The study was conducted in Indore Block of Indore District with 120 vegetable growers of 10 villages which were selected randomly and considered for study on the basis of larger area coverage. Maximum vegetable growers had low extent of adoption of the eco-friendly management practices followed by medium and high extent of adoption of the eco-friendly management practices respectively. Keywords- Eco-friendly farming, Ecological balance, Agrochemical, Sustainable farming
Nose System on The Zynq SoC Platform Amine

Electronic nose or machine olfaction are systems used for detection and identification of odorous compounds and gas mixtures. An electronic nose system is mainly made of two parts, the sensing part which takes the form of a single or a set of sensors and the processing part which takes the form of some pattern recognition algorithms. As an alternative solution to pure software or hardware implementation of the processing part of a gas identification system, this paper proposes a hardware/software co-design approach using the Zynq platform for the implementation of an electronic nose system based on principal component analysis as a dimensionality reduction technique and decision tree as a classification algorithm using two different sensors array, a 4 × 4 in-house fabricated sensor and a commercial one based on 7 Figaro sensors, for comparison purpose. The system was successfully trained and simulated in MATLAB environment prior to the implementation on the Zynq platform. Various scenarios were explored and discussed including the investigation of different combination of principal components as well as the utilization of drift compensation technique to improve the identification accuracy. High level synthesis was carried out on the proposed designs using different optimization directives including loop unrolling, array partitioning and pipelining. Hardware implementation results on the Zynq system on chip show that real-time performances can be achieved for proposed EN systems using hardware/software co-design approach with a single ARM processor running at 667 MHz and the programmable logic running at 142 MHz. In addition, using the designed IP cores and for the best scenarios, a gas can be identified in 3.46 μs using the 4 × 4 sensor and 0.55 μs using the Figaro sensors. Furthermore, it has been noticed that the choice of the sensor array has an important impact on performances in terms of accuracy and processing time. Finally, it has been demonstrated that the programmable logic of the Zynq platform consumes much less power than the processing system. c © 2017 Elsevier Ltd. All rights reserved.
Incremental Lifetime Cancer Risk of PM2.5 Bound Polycyclic Aromatic Hydrocarbons (PAHs) before and after the Wildland Fire Episode

ABSTRACTIn Northern Thailand, wildland fire during cold period releases large amounts of smoke and fine particles into the atmosphere. The fine particles include several persistent organic compounds such as PAHs. In this study, PM2.5-bound PAH concentrations in the air of nine administrative provinces, namely Chiang-Mai, Chiang-Rai, Nan, Phayao, Mae Hong Son, Phrae, Lampang, Lamphun, Uttaradit (N Thailand) were determined during the wildland fire and non-wildland fire seasons. The monitoring strategy comprised two campaigns in each season. PM2.5 was collected using MiniVolTM portable air samplers (Airmetrics) with quartz fibre filters. Both PAHs and their B[a]PEquivalent concentrations of other urban cities around the world were significantly higher than those of northern provinces for both seasons. The average cancer risks observed at nine administrative provinces were 8.525 × 10–4 ± 3.493 × 10–3 and 2.558 × 10–3 ± 6.986 × 10–3 for ingestion rate of 50 and 100 mg day–1, respectively. The excess cancer risks of world cities for ingestion rate of 50 and 100 mg day–1 were much higher than those of Northern Thailand for 851 and 567 times in that order. Dust ingestion was exceedingly critical to non-dietary PAH exposure in comparison with PM2.5 inhalation. These results are in good agreement with those of previous studies, underlining the significance of indoor air quality on long-term adverse respiratory diseases in Asian cities.
Framing the Usefulness of E-HRM in Talent Management : A Case Study of Talent Identification in a Professional Services

As talent management evolves from intuitive to evidence-based decision-making, the role of electronic Human Resource Management (eHRM) to gather, distribute, and analyze data becomes more critical. However, surprisingly few academic studies investigate the role of technology in talent management. Drawing on a qualitative case study of talent management in a large professional services firm, this paper critically examines how eHRM information technologies are framed as useful within talent identification discourses. The findings reveal two distinct but interrelated sets of processes employed to identify talent and suggest that the perceived usefulness and centrality of eHRM are influenced by how stakeholders shape their understanding of effective talent management. Disciplines Business Publication Details Wiblen, S. (2016). Framing the usefulness of eHRM in talent management: A case study of talent identification in a professional services firm. Canadian Journal of Administrative Sciences, 33 (2), 95-107. This journal article is available at Research Online: http://ro.uow. edu.au/buspapers/938 1 Framing the Usefulness of E-HRM in Talent Management: A Case Study of Talent Identification in a Professional Services Firm
PAY PERFORMANCE SENSITIVITY AND EARNINGS RESTATEMENTS

We examine whether the board of directors adjusts the sensitivity of CEO compensation to earnings following an earnings restatement. Using a sample of 598 restating firms and 2,065 non-restating firms during the period of 1995-2011, we find that firms decrease the sensitivity of cash compensation to accounting earnings after restatements and that this decrease is more pronounced for firms that appoint new CEOs after restatements than those whose CEOs continue to remain in office after restatements. Furthermore, the results suggest that the decrease in the sensitivity of cash compensation to earnings for restating firms with new CEOs is more pronounced for firms with a higher level of institutional ownership. This highlights the monitoring role of institutional investors in the redesign of compensation contracts following restatements. Overall, our results are consistent with the argument that the board adjusts the sensitivity of cash compensation to earnings downwards following restatements to constrain earnings management and recover public confidence in the firm.
Candida parapsilosis complex from animals and its antifungal susceptibility and 4 virulence attributes 5

27 This study aimed at identifying strains of the C. parapsilosis complex isolated from 28 animals, as well as to assess their in vitro antifungal susceptibility profile and in vitro 29 production of virulence attributes. We used 28 isolates of C. parapsilosis (sensu lato) 30 recovered from clinically healthy animals. The strains were phenotypically 31 characterized, followed by molecular identification of the species through PCR32 Restriction Enzyme Analysis. Then, the susceptibility of the strains to amphotericin B, 33 itraconazole, voriconazole, fluconazole and caspofungin was assessed through broth 34 microdilution, according to CLSI (M27-A3). Additionally, the ability of the strains to 35 produce biofilm, phospholipases and proteases was analyzed. Molecular analysis 36 showed thirteen C. parapsilosis (sensu stricto), ten C. orthopsilosis and five C. 37 metapsilosis strains. In vitro resistance to fluconazole was observed in three strains of 38 C. parapsilosis (sensu stricto) and two C. metapsilosis. All tested strains were able to 39 form biofilms, 23/28 isolates presented protease production, while none were able to 40 produce phospholipases. Our study shows that C. parapsilosis sensu stricto and C. 41 orthopsilosis are the most common species of the C. parapsilosis species complex and 42 that these cryptic species present no significant phenotypical differences. 43
Emphasis on Small Animals Review of Commonly Used Clinical Pathology Parameters for General Gastrointestinal Disease with

A wide variety of markers are available to assess the function and pathology of the gastrointestinal (GI) tract. This review describes some of these markers with special emphasis given to markers used in dogs and cats. Small intestinal disease can be confirmed and localized by the measurement of serum concentrations of folate and cobalamin. Fecal a1-proteinase inhibitor concentration can increase in individuals with excessive GI protein loss. A wide variety of inflammatory markers are available for a variety of species that can be used to assess the inflammatory activity of various types of inflammatory cells in the GI tract, although most of these markers assess neutrophilic inflammation, such as neutrophil elastase, calprotectin, or S100A12. N-methylhistamine can serve as a marker of mast cell infiltration. Markers for lymphocytic or eosinophilic inflammation are currently under investigation. Exocrine pancreatic function can be assessed by measurement of serum concentrations of pancreatic lipase immunoreactivity (PLI) and trypsin-like immunoreactivity (TLI). Serum PLI concentration is increased in individuals with pancreatitis and has been shown to be highly specific for exocrine pancreatic function and sensitive for pancreatitis. Serum TLI concentration is severely decreased in individuals with exocrine pancreatic insufficiency.
Trends in evapotranspiration and its drivers in Great Britain: 1961 to 2015

In a warming climate, the water budget of the land is subject to varying forces such as increasing evaporative demand, mainly through the increased temperature, and changes to the precipitation, which might go up or down. Using a verified, physically based model with 55 years of observation-based meteorological forcing, an analysis of the water budget demonstrates that Great Britain is getting warmer and wetter. Increases in precipitation (2.96.0 ± 2.03 mm yr–1 yr–1) and air temperature (0.20 ± 0.13 K decade–1) are driving increases in runoff (2.18 ± 1.84 mm yr–1 yr–1) and evapotranspiration (0.87 ± 0.55 mm yr–1 yr–1), with no significant trend in the soil moisture. The change in evapotranspiration is roughly constant across the regions, whereas runoff varies greatly between regions: the biggest change is seen in Scotland (4.56 ± 2.82 mm yr–1 yr–1), where precipitation increases were also the greatest (5.4 ± 3.0 mm yr–1 yr–1), and the smallest trend (0.33 ± 1.50 mm yr–1 yr–1, not statistically significant) is seen in the English Lowlands (East Anglia and Midlands), where the increase in rainfall is not statistically significant (1.07 ± 1.76 mm yr–1 yr–1). Relative to its contribution to the evapotranspiration budget, the increase in interception is higher than the other components. This is due to the fact that it correlates strongly with precipitation, which is seeing a greater increase than the potential evapotranspiration. This leads to a higher increase in actual evapotranspiration than the potential evapotranspiration, and a negligible increase in soil moisture or groundwater store.
Chapter 4 Relation of Trace Elements on Dental Health

Trace elements (TEs) play an important role in human health. Toxic effects are caused by deficiency or excess of TEs. TEs have significant effects on both dental health and human health. It participates in important biological polyphosphate compound functions such as ATP, DNA, and RNA. TEs are present at different concentrations in the tooth structure. Changes in the density of some TEs affect tooth. The alteration of the density of some TEs makes the teeth more susceptible to caries. Others are protective against caries formation. Important TEs zinc (Zn), phosphorus (P), and magnesium (Mg) have important effects on dental health. Measuring the TE values through tissue sampling to identify and correct these effects has an important effect. In general, tissue samples such as blood, urine, teeth, nails, and hair are used in TE studies. Teeth are accepted as appropriate indication of TEs. As a result, TEs have significant effects on healthy tooth formation.
BRANCHING PATTERN AS INFLUENCED BY PINCHING TIME IN GARLAND CHRYSANTHEMUM (CHRYSANTHEMUM CORONARIUM L.)

Plants were consistently taller in non-pinched plots. Pinching at 20 DAS recorded maximum plant height at final stage followed by pinching at 10 DAT. Pinching in nursery at 20 DAS and 10 DAT recorded the highest number of leaves and leaf area per plant due to the higher number of branches being produced by them. Number of branches, plant spread and stem girth were at maximum levels in those plants pinched in the nursery at 20 DAS. Pinching at 20 DAT appeared too had stressed the plants greatly, so that they remained significantly less spreading with lesser stem girth. Early pinched plants showed significantly more plant spread and stem girth.
THE IMPACT OF LIFE COACHING ON GOAL ATTAINMENT, METACOGNITION AND MENTAL HEALTH

Despite its high media profile and growing popularity there have been no empirical investigations of the impact of life coaching on goal attainment, metacognition or mental health. This exploratory study used life coaching as a means of exploring key metacognitive factors involved as individuals move towards goal attainment. In a within-subjects design, twenty adults completed a life coaching program. Participation in the program was associated with enhanced mental health, quality of life and goal attainment. In terms of metacognition, levels of self-reflection decreased and levels of insight increased. Life coaching has promise as an effective approach to personal development and goal attainment, and may prove to be a useful platform for a positive psychology and the investigation of the psychological mechanisms involved in purposeful change in normal, nonclinical populations. In working with individuals to improve the quality of their lives, psychology has traditionally focused on alleviating dysfunctionality or treating psychopathology in clinical or counseling populations rather than enhancing the life experience of normal adult populations. However, it is clear that the general public has a thirst for techniques and processes that enhance life experience and facilitate personal development. The market for personal development material has grown rapidly worldwide since the 1950s (Fried, 1994). Although psychologists feature infrequently as producers of this material, psychology has a genuine and important contribution to make in terms of adapting and validating existing therapeutic models for use with normal populations, and evaluating commercialized approaches to person
Intracranial aneurysms : clips or coils lderly patients with aneurysmal subarachnoid hemorrhage : Coils but also clips

The ageing of the population in good health or without severe morbidity expose them to the occurrence of a subarachnoid hemorrhage (SAH) and requires effective management. Currently, the pertinence of cerebral aneurysm treatment by clipping or coiling is accepted for patients in the 8th or 9th decade of life, and the risk of postoperative morbidity induced by our therapeutic alternative must be carefully assessed. In these decades, the female/male sex ratio for aneurysmal SAH was greater in female who had a 1.6 times higher ratio than in male. The initial clinical status did not appear worse with age despite the frequent severity of bleeding observed on CT scan probably due to the large subarachnoid space. The aneurysm distribution and size were similar to those classically reported in the global population. The endovascular (EV) coiling appears as the first option with a favorable outcome rate estimated at 48% to 63%. Nevertheless, the benefit of EV coiling compared to microsurgical clipping for treatment of ruptured aneurysm in the elderly has not been demonstrated in a large randomized study. This is the reason why the vascular section of the French Society of Neurosurgery developed a prospective and randomized study of the aneurysmal SAH (PHRC 2007–042/HP) on the elderly patients. © 2012 Elsevier Masson SAS. All rights reserved.