Miracle-dz/UniFAR-FTUs huggingface dataset:
Early Onset of Androgenetic Alopecia Associated With Early Severe Coronary Heart Disease: A Population-Based, Case-Control Study

Context The relationship of ischaemic heart disease (IHD) with androgenic alopecia (AGA) has been demonstrated, but no differentiation between early and late onsets of alopecia with regard to the risk and severity of IHD has been made. Objective To test if the early onset of alopecia is a risk factor for early severe, coronary artery disease (CAD) requiring surgery and to test if the early onset of AGA differs in this respect from the late onset of AGA. Design Population-based case-control study. Setting and participants All the 85 male persons living on 31 December 1999 in a Finnish town with total population of 7200, who had had a coronary revascularization procedure between March 1987 and January 1999, were drawn from the discharge register. For each case, an individually selected age-matched control person living in the same town was drawn from the official census register. Main outcome measure Alopecia defined as grade 3 vertex or more on the alopecia classification scale of Hamilton, modified by Norwood South Med J, 68:1359-1365, 1975. Results The unadjusted odds ratio (OR) for coronary revascularization under the age of 60 years was 3.57 (95% confidence interval (CI) 1.19-10.72) in men with an early onset of AGA compared with men with normal hair status or late AGA. After multivariate adjustment for the traditional CAD risk factors, the corresponding OR was 3.18 (95% CI, 1.01-10.03). The unadjusted OR for the coronary revascularization procedure at any age was 2.14 (95% CI, 1.08-4.23) in the subgroup of the men with early AGA compared to those with late AGA or normal hair status. After adjustment for traditional risk factors this OR was 1.84, being nearly significant (95% CI, 0.90-3.77). Conclusion Our results support the hypothesis that the early onset of AGA is a risk factor for an early onset of severe coronary heart disease. J Cardiovasc Risk 2001, 8:147-151 © 2001 Lippincott Williams & Wilkins.
Tunable GMM Kernels

The recently proposed "generalized min-max" (GMM) kernel can be efficiently linearized, with direct applications in large-scale statistical learning and fast near neighbor search. The linearized GMM kernel was extensively compared in with linearized radial basis function (RBF) kernel. On a large number of classification tasks, the tuning-free GMM kernel performs (surprisingly) well compared to the best-tuned RBF kernel. Nevertheless, one would naturally expect that the GMM kernel ought to be further improved if we introduce tuning parameters. In this paper, we study three simple constructions of tunable GMM kernels: (i) the exponentiated-GMM (or eGMM) kernel, (ii) the powered-GMM (or pGMM) kernel, and (iii) the exponentiated-powered-GMM (epGMM) kernel. The pGMM kernel can still be efficiently linearized by modifying the original hashing procedure for the GMM kernel. On about 60 publicly available classification datasets, we verify that the proposed tunable GMM kernels typically improve over the original GMM kernel. On some datasets, the improvements can be astonishingly significant. For example, on 11 popular datasets which were used for testing deep learning algorithms and tree methods, our experiments show that the proposed tunable GMM kernels are strong competitors to trees and deep nets. The previous studies developed tree methods including "abc-robust-logitboost" and demonstrated the excellent performance on those 11 datasets (and other datasets), by establishing the second-order tree-split formula and new derivatives for multi-class logistic loss. Compared to tree methods like "abc-robust-logitboost" (which are slow and need substantial model sizes), the tunable GMM kernels produce largely comparable results.
On WSN heterogeneity in IoT and CPSs

Over the past decades, many WSN (Wireless Sensor Network) systems have emerged. Today, the WSN systems with different technologies have started to become parts of Internet of Things (IoT) and Cyber-Physical Systems(CPSs). This situation has also led to the emergence of heterogeneous and autonomous WSN structures. In these types of complex projects, involving different WSN systems, it is necessary to well define the structure of WSN heterogeneity in order to perform some important operations such as interoperability and resource-sharing. To this end, the paper presents a WSN heterogeneity classification model. In the classification, WSN heterogeneity is addressed from a general perspective. The classification considers not only the heterogeneity within a WSN but also the heterogeneity which can be occurred in the scope of IoT/CPS projects. As far as is known, this type of classification on WSN heterogeneity has been proposed for the first time in literature.
Proteasome Inhibitors Activate Stress Kinases and Induce Hsp72

Inhibition of the major cytosolic protease, proteasome, has been reported to induce programmed cell death in several cell lines, while with other lines, similar inhibition blocked apoptosis triggered by a variety of harmful treatments. To elucidate the mechanism of pro- and antiapoptotic action of proteasome inhibitors, their effects on U937 lymphoid and 293 kidney human tumor cells were tested. Treatment with peptidyl aldehyde MG132 and other proteasome inhibitors led to a steady increase in activity of c-Jun N-terminal kinase, JNK1, which is known to initiate the apoptotic program in response to certain stresses. Dose dependence of MG132-induced JNK activation was parallel with that of apoptosis. Furthermore, inhibition of the JNK signaling pathway strongly suppressed MG132-induced apoptosis. These data indicate that JNK is critical for the cell death caused by proteasome inhibitors. An antiapoptotic action of proteasome inhibitors could be revealed by a short incubation of cells with MG132 followed by its withdrawal. Under these conditions, the major heat shock protein Hsp72 accumulated in cells and caused suppression of JNK activation in response to certain stresses. Accordingly, pretreatment with MG132 reduced JNK-dependent apoptosis caused by heat shock or ethanol, but it was unable to block JNK-independent apoptosis induced by TNFα. Therefore, proteasome inhibitors activate JNK, which initiates an apoptotic program, and simultaneously they induce Hsp72, which suppresses JNK-dependent apoptosis. A balance between these two effects might define the fate of cells exposed to the inhibitors.
GPU Approach to FPGA placement based on star+

While simulated-annealing is currently the most widely used method for performing FPGA placement, it does not scale to very large designs. Modern many-core architectures (including GPUs) offer a promising alternative to traditional multi-core processors for improving runtime performance. In this work, we propose a GPU-accelerated simulated-annealing variant for FPGA placement. Our approach uses the Star+ wirelength model along with a novel method of efficiently generating large sets of independent swap operations, providing a high level of parallelism. Speedups from 5.4-89.2× (median 20.2×) were achieved over a single-core CPU-only implementation.
Pharmacokinetic study of alpha1-antitrypsin infusion in alpha1-antitrypsin deficiency.

OBJECTIVES To ascertain how long 120 mg/kg alpha1-antitrypsin concentrate (alpha1-AT-C), administered I.V. every 2 weeks, can maintain alpha1-antitrypsin (alpha1-AT) serum levels above 70 to 80 mg/dL. Secondary objectives were to summarize the nature, severity, and relationship of a plasma-derived alpha1-AT-C infusion to any side effects. METHODS This was an open-label uncontrolled pharmacokinetic study. Alpha1-AT-C was administered I.V. every 2 weeks for 10 infusions in 23 patients with PIZ alpha1-AT deficiency. Serum alpha1-AT levels and neutralizing elastase activity were measured preinfusion, postinfusion, and at nadir. During two infusion periods, daily serum alpha1-AT and neutralizing elastase activities were measured on the seventh to 14th days. Five patients received BAL assays for alpha1-AT and neutralizing elastase activity. Adverse events were recorded in a patient diary and by a nurse at each infusion visit. RESULTS The 120-mg/kg dose of alpha1-AT-C could not maintain nadir serum protective levels above 70 or 80 mg/dL for the entire 14-day dosing interval in most patients. None of the patients had alpha1-AT levels above 80 mg/dL for all 14 days. The serum alpha1-AT and neutralizing elastase levels correlated suggesting functional activity. The BAL alpha1-AT and neutralizing elastase activities were low and did not correlate with serum levels. CONCLUSION Alpha1-AT-C at 120 mg/kg administered every 2 weeks did not maintain nadir serum alpha1-AT levels above 70 to 80 mg/dL for a 14-day dosing interval. Higher doses every 2 weeks or decreased interval between infusions may be required.
The role of hydrogen bonding in the enzymatic reaction catalyzed by HIV‐1 protease

The hydrogen‐bond network in various stages of the enzymatic reaction catalyzed by HIV‐1 protease was studied through quantum‐classical molecular dynamics simulations. The approximate valence bond method was applied to the active site atoms participating directly in the rearrangement of chemical bonds. The rest of the protein with explicit solvent was treated with a classical molecular mechanics model. Two possible mechanisms were studied, general‐acid/general‐base (GA/GB) with Asp 25 protonated at the inner oxygen, and a direct nucleophilic attack by Asp 25. Strong hydrogen bonds leading to spontaneous proton transfers were observed in both reaction paths. A single‐well hydrogen bond was formed between the peptide nitrogen and outer oxygen of Asp 125. The proton was diffusely distributed with an average central position and transferred back and forth on a picosecond scale. In both mechanisms, this interaction helped change the peptide‐bond hybridization, increased the partial charge on peptidyl carbon, and in the GA/GB mechanism, helped deprotonate the water molecule. The inner oxygens of the aspartic dyad formed a low‐barrier, but asymmetric hydrogen bond; the proton was not positioned midway and made a slightly elongated covalent bond, transferring from one to the other aspartate. In the GA/GB mechanism both aspartates may help deprotonate the water molecule. We observed the breakage of the peptide bond and found that the protonation of the peptidyl amine group was essential for the peptide‐bond cleavage. In studies of the direct nucleophilic mechanism, the peptide carbon of the substrate and oxygen of Asp 25 approached as close as 2.3 Å.
EEG asymmetry during covert mental activity.

Twenty subjects selected for (overt) task-induced EEG asymmetry performed 17 different covert mental tasks while EEG was recorded from right and left temporoparietal leads. After each task, subjects rated their experiences on four scales: (covert) verbalization, visual imagery, affect, and concentration. Zero-order and semipartial correlations between integrated EEG measures and subjective ratings showed that verbalization and concentration were systematically related to EEG asymmetry. The results suggest that verbal processes may be a more important influence on temporoparietal EEG asymmetry than are visual imagery processes, at least during purely covert tasks. The results also demonstrate that EEG asymmetry reflects lateralized cognitive processes occurring in the absence of external stimuli or overt responses.
Bacteremia in children: epidemiology, clinical diagnosis and antibiotic treatment

The diagnosis of bacteremia in children is important and it can be clinically challenging to recognize the signs and symptoms. The reported rates of bacteremia are higher in young children but with the increasing vaccine coverage, there has been a decrease in bacteremia due to the three vaccine preventable bacteria (Streptococcus pneumoniae, Haemophilus influenzae group b and Neisseria meningitidis). Notably, there have been increases in healthcare-associated bacteremias with a rise in Staphylococcus aureus and Gram negative bacteremias. This review provides a brief overview of the clinical diagnosis of bacteremia in children, focusing on the epidemiology, clinical characteristics, risk factors, antibiotic treatment, outcomes and preventative measures to reduce the incidence of bacteremia and improve morbidity and mortality.
Hypoglycemic Activity of Aqueous and Ethylacetate Leaf and Stem Bark Extracts of Pappea capensis in Alloxan-Induced Diabetic BALB/c Mice

The present study was performed to determine the optimal dose of alloxan monohydrate required to induce diabetes in male BALB/c mice and investigatein vivo hypoglycemic activity of aqueous and ethylacetate leaf and stem bark extracts of Pappea capensisLin alloxanized diabetic BALB/c mice.In addition, the proximate composition of P. capensis powder was investigated. The seven groups used in determining the optimal alloxan dose to induce diabetes included the normal mice intraperitoneally administered with a single dose of 0.1ml physiological saline and doses of 50.0, 77.6, 120.4, 186.9, 290.0 and 480 mg/kg body weight in 0.1 mL of physiological saline. Blood glucose levels was determined at 0, 24 and 48 h using a glucometer.The hypoglycemic activity of aqueous and ethylacetate extracts was studied in the normal and diabetic mice orally administered with 0.1ml physiological saline; diabetic mice orally administered with 0.075 mg glibenclamide, 1.25, 2.5 and 5 mg extract all in 0.1ml physiological saline. Blood glucose levels was determined at 0, 2, 4, 6 and 24 h, respectively. The proximate composition of P. capensis powder was estimated using standard procedures.Results show that asingle dose of alloxan at 186.9 mg/kg body weightadministered to 3-5 weeks old mice induced stable diabetes in 48 h; oral administration of ethylacetate leaf and stem bark extracts at 100 and 200 mg/kg body weight induced hypoglycemic activity in a dose independent manner which was similar to that of glibenclamide at 3 mg/kg body weight from the second to the twenty-fourth hour.Total ash and lipid were higher while the crude protein and carbohydrate were lower in leaves compared to the stem barks. In conclusion, P. capensis is a nutritious plant whose ethylacetate extracts possess in vivo hypoglycemic activity.
Measuring the effects of an international health professions faculty development fellowship: the FAIMER Institute

While there are many examples of evaluations of faculty development programs in resource rich countries, evaluation of transnational programs for faculty from developing countries is limited. We describe evaluation of the effects of the FAIMER Institute, an international health professions education fellowship that incorporates not only education content, but also leadership and management topics and, in addition, strives to develop a sustained community of educators. Data were obtained via retrospective pre/post surveys, as well as interviews. Results indicate that participating health professions faculty from developing countries are augmenting their knowledge and skills in education leadership, management, and methodology, and applying that knowledge at their home institutions. Fellows’ perceptions of importance of, and their own competence in, all curriculum theme areas increased. Interviews confirmed a nearly universal gain of at least one leadership skill. Findings suggest that the high-engagement experience of the FAIMER model offering integration of education and leadership/management tools necessary to implement change, provides knowledge and skills which are useful across cultural and national contexts and results in the development of a supportive, global, professional network.
Impacts of Leadership on Project-Based Organizational Innovation Performance: The Mediator of Knowledge Sharing and Moderator of Social Capital

With the increasing importance of leadership in project-based organizations, innovation is essential for the sustainable development of construction projects. Since few studies have explored the relationship between leadership and innovation in construction projects, this study fills this research gap and makes a significant theoretical contribution to the existing body of literature. Based on a knowledge-rated and resource-based view, this study aims to investigate various effects of different types of leadership on innovation performance in a construction project-based organization. Therefore, a theoretical model was constructed to explore the mediation mechanism and boundary condition of different types of leadership to improve innovation. The theoretical model was validated with empirical data covering project managers and engineers from the project-based organization in China via regression analysis and path analysis. The results show that transformational leadership and transactional leadership have some positively significant effects on knowledge sharing and innovation performance. Meanwhile, knowledge sharing partially mediates the relationship between transformational leadership and/or transactional leadership and innovation performance. Additionally, by considering different levels of social capital, transformational leadership is likely to have a strong positive impact on innovation performance through knowledge sharing. Our findings ensure a better understanding of the role of leadership, knowledge management, and social capital in the innovation process of construction projects. Therefore, project managers should promote a higher stimulation of a leadership behavior, encouraging knowledge management, and establishing the social capital, thus improving the innovation performance in the project-based organizations in construction projects.
18F-FDG-PET evaluation of pathological tumour response to neoadjuvant therapy in patients with NSCLC

ObjectivesThe ability to identify potential responders to neoadjuvant treatment may improve patient selection or surgery and may help in the development of response criteria suitable for routine monitoring of response. The aim of this study was to evaluate the value of PET in predicting the pathological tumour response of non-small-cell lung cancer (NSCLC) to neoadjuvant therapy using a meta-analysis. MethodsAll available published studies investigating the value of PET in predicting the pathological response of NSCLC to neoadjuvant therapy were collected. Pooled sensitivity and specificity data were obtained using statistical software. Subgroup analysis was performed to explore the sources of heterogeneity. ResultsA total of 13 studies comprising 414 patients with NSCLC were included in the meta-analysis. Pooled sensitivity, specificity, positive predictive value and negative predictive value for PET-predicted response was 83% [95% confidence interval (CI); 76–89%], 84% (95% CI; 79–88%), 74% (95% CI; 67–81%) and 91% (95% CI; 87–94%), respectively. Significant heterogeneity (P<0.05) was observed. On the basis of our subgroup analyses, methodological quality could be responsible for this heterogeneity in our metaregression. The predictive value of PET in NSCLC patients with pathological response (considered the gold standard) was significantly higher than that of computed tomography (P<0.05). ConclusionPET scanning has an important role in predicting nonresponders to neoadjuvant therapy in cases of NSCLC, and the predictive value of PET for evaluating pathologically documented responses is superior to that of computed tomography. However, additional evaluations using prospective clinical trials will be required to assess the clinical benefit of this strategy.
Conserved Allosteric Hot Spots in the Transmembrane Domains of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channels and Multidrug Resistance Protein (MRP) Pumps*

Background: Multidrug resistance proteins (MRPs) and the cystic fibrosis transmembrane conductance regulator (CFTR) are thermodynamically distinct ATP-binding cassette (ABC) transporters. Results: Structural elements that couple ATP binding to channel opening in the CFTR channel also facilitate MRP drug export. Conclusion: MRPs and CFTR share components of a conserved activation mechanism. Significance: Allosteric hot spots suggest mechanistic similarities between thermodynamically distinct ABC transporters. ATP-binding cassette (ABC) transporters are an ancient family of transmembrane proteins that utilize ATPase activity to move substrates across cell membranes. The ABCC subfamily of the ABC transporters includes active drug exporters (the multidrug resistance proteins (MRPs)) and a unique ATP-gated ion channel (cystic fibrosis transmembrane conductance regulator (CFTR)). The CFTR channel shares gating principles with conventional ligand-gated ion channels, but the allosteric network that couples ATP binding at its nucleotide binding domains (NBDs) with conformational changes in its transmembrane helices (TMs) is poorly defined. It is also unclear whether the mechanisms that govern CFTR gating are conserved with the thermodynamically distinct MRPs. Here we report a new class of gain of function (GOF) mutation of a conserved proline at the base of the pore-lining TM6. Multiple substitutions of this proline promoted ATP-free CFTR activity and activation by the weak agonist, 5′-adenylyl-β,γ-imidodiphosphate (AMP-PNP). TM6 proline mutations exhibited additive GOF effects when combined with a previously reported GOF mutation located in an outer collar of TMs that surrounds the pore-lining TMs. Each TM substitution allosterically rescued the ATP sensitivity of CFTR gating when introduced into an NBD mutant with defective ATP binding. Both classes of GOF mutations also rescued defective drug export by a yeast MRP (Yor1p) with ATP binding defects in its NBDs. We conclude that the conserved TM6 proline helps set the energy barrier to both CFTR channel opening and MRP-mediated drug efflux and that CFTR channels and MRP pumps utilize similar allosteric mechanisms for coupling conformational changes in their translocation pathways to ATP binding at their NBDs.