Miracle-dz/UniFAR-FTUs huggingface dataset:
L-Domain Flanking Sequences Are Important for Host Interactions and Efficient Budding of Vesicular Stomatitis Virus Recombinants

ABSTRACT Vesicular stomatitis virus (VSV) possesses a PPPY and a PSAP motif within the matrix (M) protein. The PPPY motif has significant L-domain activity in BHK-21 cells, whereas the PSAP motif does not. Since the core PSAP motif alone is insufficient to provide L-domain activity, we modified upstream or downstream amino acids flanking the PSAP core motif to determine their effect on L-domain activity. VSV recombinants were recovered that contained single or multiple amino acid mutations in upstream or downstream sequences flanking the PSAP core. Recombinant viruses were examined for growth kinetics, budding efficiency, and functional interactions with host proteins. We demonstrate that the composition of amino acids surrounding the L-domain core motifs are critical for efficient L-domain activity and for interactions with host proteins in the context of a VSV infection.
Prevalence of Diabetes in Michigan School-age Children

A mail survey of Michigan school districts elicited information of 2,816 children and adolescents with diabetes, a rate of 1.6 per 1,000. Rates were higher for females than males and for whites than non-whites and increased with advancing age. A total of 15.5 per cent were reported to be not receiving insulin by injection.
Factors Influencing the Information and Communication Technology (ICT) of Third Party Logistics in Malaysia

Abstract — The function of Information Communication Technology is still unevenly distributed among the logistics providers leading to sizeable front-liners controlling the logistics market. The ICT involves directly with the customer relationships, manufacturing, transportation, warehousing networks and data streams. This study targeted at providing remedies to the most of existing gaps relating the influence of ICT facilities in logistics industry especially among the 3PLs in Malaysia. Third Party Logistics Services can be referred as an outsourcing of transport and logistics activities belong to other companies in the movement of goods to meet their purpose. In most cases, more than one activity is outsourced and it includes storage, warehousing and transportation. The study utilized in the used of questionnaire to gather the required information from Third party logistics service providers. The data were analysed among 150 respondents and the correlated result shows that the selection of an appropriate tool of ICT has a significant impact on the competitive advantage of third party logistics companies. The result of the study is able to be used for the measurement of the performance and benchmarking on the importance of ICT in leading the 3PLs logistics industry in future. Keywords— Information, communication, technology, third party Logistics, transportation, competitive advantage
Bowenoid Papulosis of the Genitalia Associated with Human Papillomavirus DNA Type 16 in an Infant with Atopic Dermatitis

Abstract: A case of bowenoid papulosis occurred in a 2‐year‐old male with atopic dermatitis. Clinical and histologic features of the lesions were typical, and human papillomavirus type 16 DNA was identified using high‐stringcncy hyhridization techniques. Although the lesions had been present for approximately one year prior to examination, they subsequently resolved spontaneously over six months. We postulate that our patient's susceptibility to human papillomavirus may have been related to his severe atopic tendency. Presented in part at the ninth annual meeting of the Society for Pediatric Dermatology, Stateline, Nevada, June 1984.
Crowbar-less ride through of asymmetrical gric faults with DFIG based WECS

Due to the increased renewable power penetration level renewable power plants have to provide low-voltage ride-through (LVRT) capability with simultaneous dynamic voltage support, to ensure the grid stability during grid faults. Concerning doubly fed induction generator (DFIG) based wind energy conversion systems (WECS) large electromotive forces and rotor currents, which may damage the rotor-side converter, or adversely affect the DFIG's controllability are induced into the rotor circuit in case of voltage dips. To handle and limit the rotor currents in case of asymmetrical voltage dips without crowbar triggering, a virtual resistance control approach based on the standard dq-control in the synchronous reference frame is discussed. The theoretical results are compared with those of more demanding virtual inductance control. The LVRT capability is verified with measurement results, recorded during a certification campaign at a 2.1 MW WECS concerning the Indian grid code.
The potent calcitonin gene-related peptide receptor antagonist, telcagepant, does not affect nitroglycerin-induced vasodilation in healthy men.

AIMS To assess the effect of the calcitonin gene-related peptide (CGRP) receptor antagonist, telcagepant, on the haemodynamic response to sublingual nitroglycerin (NTG). METHODS Twenty-two healthy male volunteers participated in a randomized, placebo-controlled, double-blind, two-period, crossover study. Subjects received 500 mg telcagepant or placebo followed, 1.5 h later, by 0.4 mg NTG. To assess the haemodynamic response the following vascular parameters were measured: blood pressure, aortic augmentation index (AIx) and brachial artery diameter (BAD). Data are presented as mean (95% confidence interval, CI). RESULTS The aortic AIx following NTG decreased by -18.50 (-21.02, -15.98) % after telcagepant vs. -17.28 (-19.80, -14.76) % after placebo. The BAD fold increase following NTG was 1.14 (1.12, 1.17) after telcagepant vs. 1.13 (1.10, 1.15) after placebo. For both AIx and BAD, the hypothesis that telcagepant does not significantly affect the changes induced by NTG is supported (P < 0.0001). In addition, no vasoconstrictor effect of telcagepant could be demonstrated. CONCLUSIONS Telcagepant did not affect NTG-induced haemodynamic changes. These data suggest that NTG-induced vasodilation is not CGRP dependent.
Do ownership structures really matter? A study of companies listed on the Indonesia stock exchange

Examining the ownership structure of Indonesian corporations and its contribution towards developing appropriate corporate governance is an interesting endeavour, as the country is putting a lot of effort in improving trusts and attracting more foreign investors. A concentrated ownership structure is a common feature in the Asia-Pacific region. For the present paper, an analysis was conducted centred on ownership structures and their impact on governance and firm value in Indonesia. Measurements for ownership structure were based on the percentages of institutional and managerial ownership, while independent commissioners, board of directors and audit committees were used to measure corporate governance and Tobinâ€™s Q was used to measure firm value. The results of the study, which is based on secondary data gathered from all the companies listed on the Indonesia Stock Exchange from 2009 to 2016, reveals that ownership structure affects two measures used for corporate governance and firm value. As expected, ownership structure shows a statistically significant relationship with corporate governance.
MEKANISME CORPORATE GOVERNANCE TERHADAP NILAI PERUSAHAAN DENGAN KUALITAS LABA SEBAGAI VARIABEL INTERVENING

The objectives of the study were to investigate the relationship between corporate governanceand earnings quality, earnings quality and value of the fi rm, corporate governance mechanismand value of the fi rm, and whether earnings quality was the intervening variable between corporategovernance and value of the fi rm. By using 74 samples and 197 observations, the result indicatedthat fi rst, corporate governance infl uenced earnings quality. (1)Managerial ownership positively influenced earnings quality, (2) Board of commissioner negatively infl uenced earnings quality, (3) Auditcommittee positively infl uenced earnings quality. Second, earnings quality positively infl uenced valueof fi rm. Third, corporate governance mechanism infl uenced value of the fi rm. Finally, the result indicatedthat earnings quality was not the intervening variable between corporate governance mechanismand value of the fi rm.
Reply to Hagedorn , Manovskii , and Mitman on “ Interpreting Recent Quasi-Experimental Evidence on the Effects of Unemployment Benefit Extensions ”

In a new working paper (Chodorow-Reich and Karabarbounis, 2016, henceforth CRK), we presented novel evidence showing the limited influence of unemployment benefit extensions on state-level macroeconomic outcomes such as unemployment, vacancies, employment, and wages. We welcome comments on our paper and have facilitated the exploration of our results by other researchers by making the dataset that underlies our analysis available on our webpages. In a recent comment, Hagedorn, Manovskii, and Mitman (2016, henceforth HMM) use our dataset to criticize the evidence presented in CRK. The HMM criticism focuses on two aspects of our work. We show that their first criticism does not apply to the empirical framework actually implemented in CRK. Their second criticism is already answered by the exercise we conduct in Section 4 of CRK and which receives no mention in HMM. We first summarize our responses to the HMM criticisms and then present our arguments in more detail.
Electrical aging and life models: the role of space charge

This paper has the aim of providing a view of a lively debated topic which has broad impact on the design of electrical apparatus and new insulating materials, that is, the interaction between space charge and aging processes of polymeric insulation. Aging models developed in recent decades that consider explicitly or implicitly the contribution of space charge to insulation degradation, under both DC and AC voltage, are dealt with, with the intention to point out their range of validity. Some conventional phenomenological models that have been used for much more than two decades without referring to space charges can be exploited to account for electrical field and activation energy modification due to space charge. These, together with models conceived considering space charges as the driving force for aging, are especially examined. In addition, recent models that disregard the action of space charge as an ageing factor, but consider space charge as the consequence of degradation processes are also discussed.
Human-Animal Relationships: The Use of Species-Typical Food Calls and Chimpanzee (Pan troglodytes) Names: Welfare-Oriented Tools to Manage Sanctuary Chimpanzees

In captivity, positive human-animal interactions are often part of daily management procedures, which can enhance the welfare of animals and help caregivers with routine husbandry tasks. For example, the provisioning of food (produce or enrichment) can be an effective tool to reward animals for positive behavior. Another option is to use species-typical behavior to request an action on the part of the animal. In both captive and wild settings, chimpanzees (Pan troglodytes) use a variety of food vocalizations to announce the presence of different food sources. In this study, we examined how species-typical vocalizations (chimpanzee-based food calls, CBFCs) compared to human vocalizations (name-calling and encouragement, NCE) in relation to the shifting behavior of sanctuary chimpanzees at Chimp Haven, Inc., during routine husbandry tasks. Both CBFCs and NCE were associated with the provisioning of enrichment or produce, and observations were balanced for time of day. We found that CBFCs were slightly more effective in shifting of the chimpanzees when it was used along with the provisioning of enrichment (n = 22, p = 0.017). We also found that the chimpanzees were more likely to shift in the morning rather than in the afternoon (n = 34, p = 0.012). These results suggest that predictable schedules and the use of positive communication, whether it is in the form of a species-typical food call or the calling of a chimpanzee’s name and general positive encouragement, assisted in the daily management of chimpanzees housed in a sanctuary setting.
Germination ecology of Cassava (Manihot esculenta Crantz, Euphorbiaceae) in traditional agroecosystems: Seed and seedling biology of a vegetatively propagated domesticated plant

Cassava is clonally propagated, but Amerindian farmers also use plants from volunteer seedlings to prepare stem cuttings. Although sexual reproduction plays a role in cassava’s evolution it is poorly studied. We examined one aspect of cassava reproductive ecology, seed dormancy and germination. Volunteer seedlings emerge from a soil bank of seeds produced during the previous cycle of cultivation that remain ungerminated through the fallow period, then germinate synchronously after vegetation is slashed and burned. Laboratory experiments showed that germination can be enhanced by mechanical scarification and also by dry heat treatment, suggesting that burning after field clearing could help break dormancy. Germination was also stimulated by high temperatures (35°C) that in nature indicate bare soils, and inhibited by temperatures (25°C) close to those in soil shaded by vegetation and by light. Seeds of both wild and domesticated cassava exhibit physiological dormancy, an adaptation for germination in periodically disturbed habitats. In addition to these preadaptations, preliminary results also suggest specific adaptations of domesticated cassava to the distinctive disturbance regimes of swidden agriculture.
Ayuntamiento de Madrid

Las presentes bases regulan las especificidades de los procesos selectivos para proveer plazas de la categoría de Policía del Cuerpo de Policía Municipal del Ayuntamiento de Madrid por el sistema de movilidad sin ascenso que regula el artículo 65.2 del Reglamento Marco de Organización de las Policías Locales de la Comunidad de Madrid, aprobado por Decreto 112/1993, de 28 de octubre de la Comunidad de Madrid.
A GRU-based Mixture Density Network for Data-Driven Dynamic Stochastic Programming

The conventional deep learning approaches for solving time-series problem such as long-short term memory (LSTM) and gated recurrent unit (GRU) both consider the time-series data sequence as the input with one single unit as the output (predicted time-series result). Those deep learning approaches have made tremendous success in many time-series related problems, however, this cannot be applied in data-driven stochastic programming problems since the output of either LSTM or GRU is a scalar rather than probability distribution which is required by stochastic programming model. To fill the gap, in this work, we propose an innovative data-driven dynamic stochastic programming (DD-DSP) framework for time-series decision-making problem, which involves three components: GRU, Gaussian Mixture Model (GMM) and SP. Specifically, we devise the deep neural network that integrates GRU and GMM which is called GRU-based Mixture Density Network (MDN), where GRU is used to predict the time-series outcomes based on the recent historical data, and GMM is used to extract the corresponding probability distribution of predicted outcomes, then the results will be input as the parameters for SP. To validate our approach, we apply the framework on the car-sharing relocation problem. The experiment validations show that our framework is superior to data-driven optimization based on LSTM with the vehicle average moving lower than LSTM.
Metabolic flux analysis of RQ‐controlled microaerobic ethanol production by Saccharomyces cerevisiae

Microaerobic ethanol production by Saccharomyces cerevisiae CBS 8066 was investigated at different growth rates in respiratory quotient (RQ)‐controlled continuous culture. The RQ was controlled by changing the inlet gas composition by a feedback controller while keeping other parameters constant. The ethanol yield increased slightly from the anaerobic values with decreasing RQ, reaching a broad maximum at RQ 20 to 12. There was little or no glycerol production at RQ values below 17 over a wide range of dilution rates. Metabolic flux analysis revealed that a decrease in the ethanol yield at RQ 6 coincided with the cyclic, oxidative operation of the TCA cycle reactions. The model indicated that respiratory dissimilation of glucose only occurs when the oxygen uptake rate is high enough to completely substitute for glycerol formation. The cytosolic and the mitochondrial NADH balances were important for determining the flux distributions. The smallest deviations between estimated and measured product yields were obtained when the unknown co‐factor requirements of a limited number of biosynthetic reactions were chosen so that the amount of excess NADH formed in biosynthesis was minimized. The biomass yield was positively correlated with the net amount of NADH reoxidized in respiration and glycerol formation, indicating that the turnover of excess NADH from biosynthesis is an important factor influencing the biomass yield under oxygen‐limiting conditions. Copyright © 2002 John Wiley & Sons, Ltd.
Clinical characteristics and viral load of respiratory syncytial virus and human metapneumovirus in children hospitaled for acute lower respiratory tract infection

Respiratory syncytial virus (RSV) and human metapneumovirus (HMPV) are two common viral pathogens in acute lower respiratory tract infections (ALRTI). However, the association of viral load with clinical characteristics is not well‐defined in ALRTI. To explore the correlation between viral load and clinical characteristics of RSV and HMPV in children hospitalized for ALRTI in Lanzhou, China. Three hundred and eighty‐seven children hospitalized for ALRTI were enrolled. Nasopharyngeal aspirates (NPAs) were sampled from each children. Real‐time PCR was used to screen RSV, HMPV, and twelve additional respiratory viruses. Bronchiolitis was the leading diagnoses both in RSV and HMPV positive patients. A significantly greater frequency of wheezing (52% vs. 33.52%, P = 0.000) was noted in RSV positive and negative patients. The RSV viral load was significant higher in children aged <1 year (P = 0.003), children without fever and wheezing (P = 0.015 and P = 0.000), days of illness <14 days (P = 0.002), children with bronchiolitis (P = 0.012) and children with RSV single infections (P = 0.000). No difference was found in the clinical features of HMPV positive and negative patients. The HMPV viral load had no correlation with any clinical characteristics. The incidences of severe disease were similar between single infection and coinfection for the two viruses (RSV, P = 0.221; HMPV, P = 0.764) and there has no statistical significance between severity and viral load (P = 0.166 and P = 0.721). Bronchiolitis is the most common disease caused by RSV and HMPV. High viral load or co‐infection may be associated with some symptoms but neither has a significant impact on disease severity for the two viruses. J. Med. Virol. 89:589–597, 2017. © 2016 Wiley Periodicals, Inc.
Essays on Auditing and Financial Reporting Regulation

This dissertation consists of three essays on auditing and current regulatory changes in financial reporting. The first essay investigates empirically how audit firms’ compensation policies are associated with audit quality provided by individual auditors. The second and third essay illustrates, evaluates and analyzes current proposals for reforms from the US PCAOB (Public Company Accounting Oversight Board) and from ESMA (European Securities and Market Authority).
Immunohistochemical profile and fluorescence in situ hybridization analysis of diffuse large B-cell lymphoma in northern China.

CONTEXT Gene expression profiling of diffuse large B-cell lymphoma using complementary DNA microarrays has revealed 2 major prognostic groups in Western countries: germinal center B-cell-like and nongerminal center B-cell-like lymphomas. Immunohistochemical analysis using antibodies specific for CD10, BCL6, and MUM1 has been proposed as a surrogate for gene expression profiling. OBJECTIVE To study the immunohistochemical features of diffuse large B-cell lymphoma cases from northern China because geographic differences for this disease are known to exist. DESIGN Morphologic, immunohistochemical, and fluorescence in situ hybridization analyses of 63 cases of diffuse large B-cell lymphoma from northern China. RESULTS There were 38 men and 25 women with a median age of 57 years (range, 12-87 years). CD10 was positive in 19 cases (30%), BCL6 was positive in 22 cases (35%), and MUM1 was positive in 32 cases (51%). Twenty-one (33%) cases were germinal center B-cell-like lymphoma, and 42 (67%) were nongerminal center B-cell-like lymphoma. BCL2 was expressed more often in nongerminal center B-cell-like disease versus germinal center B-cell-like disease (60% versus 24%, P = .01) and in nodal versus extranodal (64% versus 30%, P = .01) cases. Fluorescence in situ hybridization analysis showed BCL6, MYC , and BCL2 rearrangements in 11 of 32 (34%), 8 of 27 (30%), and 11 of 50 (22%) cases, respectively. CONCLUSIONS These results add to what is known about the geographic variation of diffuse large B-cell lymphomas. In northern China, the frequency of the germinal center B-cell-like type and BCL6 expression and/or BCL6 rearrangement is less and the frequency of MYC rearrangement is greater than have been reported in Western countries.
Using Strategic Uncertainty to Persuade Multiple Agents

A principal wishes to persuade multiple agents to take a particular action profile. Each agent cares about both a payoff-relevant state and others’ actions. The principal discloses information about the state to control the agents’ behavior by using their strategic uncertainty. We show that she can persuade them to take an action profile for any non-degenerate prior if that action profile satisfies a generalization of risk dominance. Moreover, such an action profile can be sustained in ways that are “collusion-proof. ”
Frontal operculum temporal difference signals and social motor response learning

Substantial experimental evidence supports the theory that the dopaminergic system codes a phasic (short duration) signal predicting the delivery of primary reinforcers, such as water when thirsty, during Pavlovian learning. This signal is described by the temporal difference (TD) model. Recently, it has been suggested that the human dopaminergic system also codes more complex cognitive goal states, including those required for human social interaction. Using functional magnetic resonance imaging (fMRI) with 18 healthy subjects, we tested the hypothesis that TD signals would be present during a Pavlovian learning task, and during a social motor response learning task. Using an identical model, TD signals were present in both tasks, although in different brain regions. Specifically, signals were present in the dorsal anterior cingulate, ventral striatum, amygdala, and thalamus with Pavlovian learning, and the dorsal anterior cingulate and bilateral frontal operculum with social motor response learning. The frontal operculum is believed to be the human homologue of the monkey mirror neuron system, and there is evidence which links the region with inference about other peoples' intentions and goals. The results support the contention that the human dopaminergic system predicts both primary reinforcers, and more complex cognitive goal states, such as motor responses required for human social group interaction. Dysfunction of such a mechanism might be associated with abnormal affective responses and incorrect social predictions, as occur in psychiatric disorders. Hum Brain Mapp 2009. © 2008 Wiley‐Liss, Inc.