Miracle-dz/UniFAR-FTUs huggingface dataset:
Family support and cardiovascular responses in married couples during conflict and other interactions

This study examined the relation between perceived support from family and cardiovascular (CV) responses to interaction in 45 married couples, 24 to 50 years old. Gender-specific median splits on Family Support scores from the Brief Social Support Questionnaire defined high versus low support groups. CV responses were obtained from both spouses during baseline and 3 stressors: reading control, conversing about events of the day, and conflict discussion. Men with low support had higher systolic (SBP) and diastolic pressure (DBP) than men with high support or either group of women at baseline and during all task periods (p < .004 and .05). Women with high support did not differ in blood pressure (BP) from women with low support. Men and women with low support had higher vascular resistance indexes (VRI) than those with high support, during all periods (p < .0015), and reported lower dyadic satisfaction and total dyadic adjustment. Because a disproportionate number of non-While participants reported low family support, secondary analyses that included race as a covariate were conducted. Covarying for race did not produce substantial results for any of the measures (SBP,p < .05; DBP,p < .058; VRI, p < .021). Post-hoc analyses were also conducted, in which the marital dyad was considered the unit of analysis. For these analyses, in which both spouses’ perceptions of family support as high or low were considered together, the wife’s perceived support did not influence the husband’s BP, whereas his perceived support did influence his BP (ps < .03). For VRI in both men and women, the spouses’ support level, as well as the participant’s own support level, affected responses (ps < .02). Thus, high family support is associated with both marital and CV benefits for both husbands and wives, although husbands may benefit more.
Tree Nut Allergy, Egg Allergy, and Asthma in Children

Background. Children with food allergies often have concurrent asthma. Objective. The authors aimed to determine the prevalence of asthma in children with food allergies and the association of specific food allergies with asthma. Methods. Parental questionnaire data regarding food allergy, corroborated by allergic sensitization were completed for a cohort of 799 children with food allergies. Multivariate regression analysis tested the association between food allergy and reported asthma. Results. In this cohort, the prevalence of asthma was 45.6%. After adjusting for each food allergy, environmental allergies, and family history of asthma, children with egg allergy (odds ratio [OR] = 2.0; 95% confidence interval [CI] = 1.3-3.2; P < .01) or tree nut allergy (OR = 2.0; 95% CI = 1.1-3.6; P = .02) had significantly greater odds of report of asthma. Conclusion. There is a high prevalence of asthma in the food-allergic pediatric population. Egg and tree nut allergy are significantly associated with asthma, independent of other risk factors.
CYP2D6 polymorphism and clinical effect of the antidepressant venlafaxine

Background: Venlafaxine (V) is a mixed serotonin and noradrenaline reuptake inhibitor used as a first‐line treatment of depressive disorders. It is metabolized primarily by the highly polymorphic cytochrome P450 (CYP) enzyme CYP2D6 to yield a pharmacologically active metabolite, O‐desmethylvenlafaxine (ODV), and to a lesser extent by CYP3A4, to yield N‐desmethylvenlafaxine (NDV).
Alien, Illegal, Undocumented: Labeling, Context, and Worldview in the Immigration Debate and in the Lives of Undocumented Youth

Alien, Illegal, Undocumented: Labeling, Context, and Worldview in the Immigration Debate and in the Lives of Undocumented Youth By David A. Caicedo, M.A., M.Phil. Advisor: Colette Daiute, Ed.D. A key element of investigating attitudes towards unauthorized immigrants in the United States has been political orientation, yet few studies have examined the influence of such orientation on labels relevant to the immigration debate. The current dissertation project examined these attitudes among young adults using survey, focus group, and interview methodologies. Level of agreement on various statements regarding unauthorized immigrants was examined in Study I, definitions given for the labels ‘illegal’ and ‘undocumented’ were explored in Study II, and the lived experience of undocumented youth in two community colleges was investigated in Study III. It was hypothesized that: I) attitudes concerning unauthorized immigrants are a function of present social labels, regardless of political orientation; II) social label definitions reflect distinct cognitive processes; and III) the lived experiences of undocumented students reflect the respective social environments of an urban and suburban community college. Participants in Study I were 744 (463 urban/272 suburban) young adults, all who were recruited from “New York Community College” (NYCC, urban) and “New Jersey Community College” (NJCC, suburban); participants in Study II were 14 (8 NYCC, 6 NJCC) young adults; and participants in Study III were 7 (4 NYCC, 3 NJCC) young adults. Participants in Study I were asked to complete an attitude on unauthorized immigrants scale, followed by the General System
I know what you did last summer... an investigation into remnant data on USB storage devices sold in Australia in 2015

The demand for portable digital data storage has increased with the evolution and advancement in consumer electronic devices. USB storage devices, also referred to as USB sticks, pen drives, flash drives, thumb drives, and key drives, have replaced many other portable storage. With the evolution of these devices, an increased use for data transportation has been seen for both private and commercial data. USB storage capacity has increased during the past decades with capacities up to one terabyte available today. Such devices are increasingly popular given their robustness, low power consumption, rapid response rates, non-volatile nature, and ease of transportation. This study obtained second hand USB flash memory storage devices, purchased from eBay Australia over a period of seven months, to determine whether there were any traces of data on the devices, and whether or not an attempt had been made to securely wipe the devices. If data fragments were recovered, it was assessed to see if there was a sufficient volume and sensitivity of data to be of value to anyone with malicious intent. The findings from the research show that in the majority of the cases, the USB flash memory storage devices retained a large volume of data. Concurring with outcomes from previous studies in 2009 and 2011, the devices investigated in this study, owned by both individuals and organisations, were used to store highly sensitive and confidential data. This data was not permanently nor securely destroyed prior to disposal (by sale) of the devices. Such incidents highlight the failure to meet regulatory obligations with regard to privacy legislation in Australia.
Renal Disease and Pregnancy

Pregnancy in women with different renal diseases has important consequences for the developing fetus and maternal health. Kidneys and the urinary tract have to adapt to the pregnancy status and therefore suffer significant anatomical, hemodynamic and endocrine changes. Failure to adapt can aggravate the preexisting maternal disease and can also create suboptimal environment for fetal development and increase the risk of obstetric complications. Knowledge and correct interpretation of the renal functional tests is necessary for the modern obstetrician, avoiding an incorrect diagnosis for renal disease where only specific renal changes during pregnancy are present, but meanwhile a correct evaluation of the renal function and changes can detect a pathology that can aggravate both the mother’s and the baby’s condition. Improvement and better understanding of the renal pathophysiology in pregnancy made possible that pregnant woman look forward for a good outcome, including here also the women with renal transplant. Nowadays is underlined the concept of multidisciplinary teamwork, a very important concept of modern medicine. The obstetrician should consider nephrologists as key players in the team and in our opinion should refer to them the pregnant women for a routine check-up of the renal status in the 2nd or beginning of 3rd trimester by ultrasound, beside the usual blood and urine analysis. The nephrologists and urologists should be involved in the management of severe medical conditions, such as preeclampsia, acute and chronic renal failure and never the less in the complex management of dialysis or renal transplant patients. In pregnancy it can be encountered several renal diseases, some of them preexisting the pregnancy and other developed or being direct influenced by pregnancy. This chapter will discuss briefly the basic evaluation of renal status in order to present and better understand the acute and chronic renal disorders in pregnancy. The chapter will focus on the most common preexisting diseases in pregnancy such as: chronic glomerulonephritis, secondary glomerular nephropathies, interstitial nephropathies (chronic pyelonephritis, renal tuberculosis), diabetes nephropathy, unique surgical kidney, chronic renal failure. From the renal diseases directly influenced by pregnancy it will be discussed: asymptomatic bacteriuria, symptomatic urinary infection, urolithiasis and acute renal failure in pregnancy. It will be presented also the management of dialysis in pregnancy and pregnant women with renal transplant.
The Impact of CSR on Firms' Financial Performance - A Literature Review

This paper observes the various related literature in India and abroad along with the findings and suggestions made by diverse researchers regarding how financial performances are affected by the corporate social responsibility. In India, corporate social responsibility has been made mandatory by the Companies Act, 2013 and as a result, the Indian companies have started spending for this purpose. Central public sector enterprises of India have played a key role regarding corporate social responsibility for the development of the nation, in which, they have published a set of separate guidelines for central public sector undertakings on 12 April, 2013 that was later superseded by another set of guidelines dated 21 October, 2014. It has been observed that the findings have been divided into three groups across the globe, that is, corporate social responsibility has either a positive impact or a negative impact or no impact on firms’ financial performance.
A systematic review of continuous renal replacement therapy and intermittent haemodialysis in management of patients with acute renal failure

Background: Acute renal failure (ARF) still bears a poor prognosis with mortality rates up to 70% and the ideal form of renal replacement therapy (RRT) remains controversial. The purpose of this study was to conduct a systematic review and meta‐analysis of all randomized controlled trials (RCT) to examine the effect of dialysis modality (IHD: Intermittent haemodialysis; CRRT: continuous renal replacement therapy) on survival of patients with ARF and to also study the effect of each modality on dialysis dependence (DD).
CD5 Negatively Regulates the T-Cell Antigen Receptor Signal Transduction Pathway: Involvement of SH2-Containing Phosphotyrosine Phosphatase SHP-1

ABSTRACT The negative regulation of T- or B-cell antigen receptor signaling by CD5 was proposed based on studies of thymocytes and peritoneal B-1a cells from CD5-deficient mice. Here, we show that CD5 is constitutively associated with phosphotyrosine phosphatase activity in Jurkat T cells. CD5 was found associated with the Src homology 2 (SH2) domain containing hematopoietic phosphotyrosine phosphatase SHP-1 in both Jurkat cells and normal phytohemagglutinin-expanded T lymphoblasts. This interaction was increased upon T-cell receptor (TCR)-CD3 cell stimulation. CD5 co-cross-linking with the TCR-CD3 complex down-regulated the TCR-CD3-increased Ca2+ mobilization in Jurkat cells. In addition, stimulation of Jurkat cells or normal phytohemagglutinin-expanded T lymphoblasts through TCR-CD3 induced rapid tyrosine phosphorylation of several protein substrates, which was substantially diminished after CD5 cross-linking. The CD5-regulated substrates included CD3ζ, ZAP-70, Syk, and phospholipase Cγl but not the Src family tyrosine kinase p56 lck . By mutation of all four CD5 intracellular tyrosine residues to phenylalanine, we found the membrane-proximal tyrosine at position 378, which is located in an immunoreceptor tyrosine-based inhibitory (ITIM)-like motif, crucial for SHP-1 association. The F378 point mutation ablated both SHP-1 binding and the down-regulating activity of CD5 during TCR-CD3 stimulation. These results suggest a critical role of the CD5 ITIM-like motif, which by binding to SHP-1 mediates the down-regulatory activity of this receptor.
The statistics of synergism.

Biological scientists often want to determine whether two agents or events, for example, extracellular stimuli and/or intracellular signaling pathways, act synergistically when eliciting a biological response. When setting out to study whether two experimental treatments act synergistically, most biologists design the correct experiment--they administer four treatment combinations consisting of (1) the first treatment alone, (2) the second treatment alone, (3) both treatments together, and (4) neither treatment (i.e. the control). Many biologists are less clear about the correct statistical approach to determining whether the data collected in such an experimental design support a conclusion regarding synergism, or lack thereof. The non-additivity of two experimental treatments that is central to the definition of synergism leads to an algebraic formulation corresponding to the statistical null hypothesis appropriate for testing whether or not there is synergism. The resulting complex contrast among the four treatment group means is identical to the interaction effect tested in a two-way analysis of variance (ANOVA). This should not be surprising, because synergism, by definition, occurs when two treatments interact, rather than act independently, to influence a biological response. Hence, in the most readily implemented approach, the correct statistical analysis of a question of synergism is based on testing the interaction effect in a two-way ANOVA. This review presents the rationale for this correct approach to analysing data when the question is of synergism, and applies this approach to a recent published example. In addition, a common incorrect approach to analysing data with regards to synergism is presented. Finally, several associated statistical issues with regard to correctly implementing a two-way ANOVA are discussed.
Endometrial cancer and meat consumption: a case–cohort study

Diet plays an important role in the etiology of certain cancers, but there is limited evidence with regard to the association between diet and risk of endometrial cancer. Few prospective studies have investigated meat intake as a potential determinant of endometrial cancer risk. The objective of this study was to examine the association between endometrial cancer risk and total meat, red meat, processed meat, fish, and poultry intake. We conducted a case–cohort analysis within the Canadian Study of Diet, Lifestyle, and Health, a prospective cohort of 73 909 adults (39 614 women). Participants were recruited from 1992 to 1999, predominantly from three Canadian universities. We conducted a linkage with the Ontario Cancer Registry for the years 1992–2007 for the female cohort members, who resided in Ontario at the time of enrollment (n=26 024), to yield data on cancer incidence. The analytic sample was comprised of 107 incident cases and 1830 subcohort members, the latter being an age-stratified sample of the full cohort. A nonsignificant increase in the risk of endometrial cancer was associated with increased consumption of red meat [hazard ratio (HR)=1.62, 95% confidence intervals (CI)=0.86–3.08, for high vs. low intake; Ptrend=0.13)], processed meat (HR=1.45, 95% CI=0.80–2.61, for high vs. low intake; Ptrend=0.058), and all meat combined (HR=1.50, 95% CI=0.78–2.89, for high vs. low intake; Ptrend=0.14). No clear patterns were noted for poultry or fish. The results of this study, although based on a limited number of cases, suggest that relatively high meat intake may be associated with increased risk of endometrial cancer.
The Social Protection System for the Elderly in Brazil

This article examines the evolution of retirement in Brazil and its old-age support programs (public pension). The key objective is to show that given the current trend in population and size of the programs, their sustainability in the near future may be endangered. The analysis follows previous studies, specially Turra & Queiroz (2009), that projected the ratio of dependence of the public pension in different scenarios and show how the combination of change in the age structure and absence of proper policies make the situation of the Brazilian situation worse than could be expected. In this paper, we also provide a measure of public pension expenditure under different policy scenarios. This paper provides empirical evidence indicating that the absence of appropriate policies can, aggravate adverse effects of population aging. We show that the public pension system workers less efficiently than desired and it is already in weaker condition than system in more developed nations. We contribute to the debate on how critical policy areas may reduce the potential economic impact of demographic changes. We do not test for the effects of social security financial conditions to economic growth, but by using counterfactual projections of different measures we shed light on the roles played by demographic, policy and economic changes on the situation of the social protection system for the elderly in Brazil.
Recurrent intracranial germinoma outside the initial radiation field: A single-institution study

Between 1975 and 2005, we treated 52 newly diagnosed germinoma patients. Until 1991, patients with pure germinomas or germinomas with syncytiotrophoblastic giant cells (STGCs) received whole-brain radiotherapy only. Of the 52 patients, 30 were treated with a reduced radiation volume and combined chemotherapy; seven of these received local irradiation with 24 Gy, two received whole-brain (30 Gy) plus local irradiation (20 Gy), 16 received extended local irradiation delivered to the whole ventricles (30 Gy) plus local (20 Gy) irradiation, and five received extended local irradiation (24 Gy). Of the 30 patients treated with a reduced radiation volume and combined chemotherapy, four experienced tumor recurrence; three patients had been treated with 24 Gy of local radiotherapy and one had received extended local (30 Gy) plus local (20 Gy) irradiation in addition to chemotherapy. In these patients, the delivered radiotherapy was inadequate and the origin of the recurrent tumors was outside the radiation field. None of the patients who had received at least 24 Gy of whole ventricle radiotherapy combined with chemotherapy experienced tumor recurrence. In combination with chemotherapy, the delivery of irradiation covering the ventricles effectively reduced the incidence of tumor recurrence in patients with germinomas or germinomas with STGCs.
Effects of non-equilibrium plasma in the treatment of ligature-induced peri-implantitis.

AIM To evaluate the effects of non-equilibrium plasma in the treatment of ligature-induced peri-implantitis in beagle dogs. MATERIALS AND METHODS Six beagles received 12 implants installed in the position of the fourth mandibular premolars. Ligature-induced peri-implantitis was initiated at 3 months post-implantation. When approximately 40% of the supporting bone was lost, the ligatures were removed. The implants were subjected to the muco-periosteal scaling and chlorhexidine irrigation with or without plasma irrigation. Three months later, clinical, radiographic and microbiological analyses were performed. Block biopsies were prepared for micro-CT and histomorphometric analysis. The primary outcome was the difference in bone healing of peri-implant sites, and the secondary outcomes included changes in clinical parameters (SBI, PD) and bacterial detection. RESULTS At baseline, no significant differences were observed between the two groups. At 3 months post-treatment, the plasma group showed a significantly higher bone level than the control group (p < 0.05), a significantly decreased detection of bacteria (Porphyromonas gingivalis and Tannerella forsythia) (p < 0.05), and a significant improvement in clinical examination (p < 0.05). CONCLUSIONS Within the limits of this study, non-equilibrium plasma treatment as an adjunct to the conventional therapy is a feasible approach for the treatment of peri-implantitis.
Use of cardiopulmonary bypass to salvage patients with multiple-chamber heart wounds.

BACKGROUND The need for cardiopulmonary bypass in the treatment of penetrating heart injuries is debated. OBJECTIVES To review our experience with penetrating heart injuries and determine the indications and outcome for cardiopulmonary bypass. DESIGN Retrospective review. SETTING A university-based, level I trauma center. PATIENTS All victims of penetrating heart injury presenting between July 1, 1989, and December 31, 1995. METHODS Medical records were reviewed for demographic and physiological data, operative findings, and outcome. RESULTS Overall survival for 106 patients with penetrating heart injury was 55%. In an effort to resuscitate the heart, 4 patients with unresponsive cardiogenic shock were placed on cardiopulmonary bypass; none survived. Of 30 patients with multiple-chamber injuries, 11 presented with signs of life and 7 survived. Cardiopulmonary bypass was essential to repair complex injuries in 2 of the 7 survivors. CONCLUSION Cardiopulmonary bypass was ineffective in salvaging patients with cardiogenic shock but was essential in some patients with complex multiple-chamber cardiac injuries that could not be exposed and repaired by other means.
Formation of research collaborations between universities and firms: Towards an integrated framework of tie formation motives, processes and experiences

3 Acknowledgements . 5 List of figures. 11 List of tables . 12 List of abbreviations . 13 CHAPTER 1: INTRODUCTION. 15 1.1 RESEARCH PROBLEM AND PURPOSE . 15 1.2 THEORETICAL PERSPECTIVES . 19 1.3 CONCEPTUAL FRAMEWORK. 21 1.4 RESEARCH STRATEGY AND METHODOLOGICAL FRAMEWORK . 23 1.5 CONTRIBUTIONS AND LIMITATIONS. 26 1.6 THESIS OUTLINE . 28 CHAPTER 2: UNIVERSITY – INDUSTRY INTERACTION – A REVIEW OF LITERATURE . 31 2.