Miracle-dz/UniFAR-FTUs huggingface dataset:
Timing of Mortality After Severe Bleeding and Recurrent Myocardial Infarction in Patients With ST-Segment–Elevation Myocardial Infarction

Background—The prognosis of initial survivors of ST-segment–elevation myocardial infarction (STEMI) is affected by both recurrent myocardial infarction (MI) and severe bleeding. The aim of the current study was to investigate how mortality is affected in time after bleeding and recurrent MI. Methods and Results—From January 1, 2003, to July 31, 2008, a total of 2002 patients were treated with primary percutaneous coronary intervention for ST-segment–elevation MI and followed up for the occurrence of recurrent MI and Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Arteries (GUSTO) severe bleeding. Primary outcome was all-cause mortality within 4 years of follow-up. In a time-dependent, covariate-adjusted Cox regression model, both bleeding and recurrent MI were associated with an increase in mortality shortly after the adverse event: hazard ratio, 14.37 (95% confidence interval [CI], 7.69–26.84) for the first day after recurrent MI and 5.42 (95% CI, 2.88–10.22) for the first day after bleeding. Thereafter the risk of subsequent mortality gradually decreased but remained elevated long after a recurrent MI (hazard ratio, 4.95 [95% CI, 3.27–7.48] between 1 day and 1 year after recurrent MI and hazard ratio, 2.56 [95% CI, 1.56–4.21] beyond 1 year after recurrent MI), but decreased to nonsignificant level beyond 1 month after the bleeding (hazard ratio, 0.56 [95% CI, 0.27–1.14]). Conclusions—The occurrence of both recurrent MI and bleeding in the first year after ST-segment–elevation MI is associated with subsequent mortality. The risk implication of recurrent MI, however, was greater and more sustained over time than that of severe bleeding.
Paneth Cell Identification in the Small Intestine of Guinea Pig Offsprings (Cavia porcellus)

The aim of this study was to determine the presence, number, and morphometrical characteristics of Paneth cells (PC) in the small intestine of guinea pigs during lactation. We used 48 pups from 0 to 15 days old. Samples from small intestine were fixed in 10% buffered formaldehyde (pH 7.4) and processed for histological and morphometrical studies using hematoxylin and eosin (HE), Phloxine tartrazine or Masson's Trichome staining, or immunohistochemistry for lysozyme. PC were morphologically identified at day 2 using Masson's Trichome or Phloxine tartrazine stainings, and at day 4 using HE, whereas using immunohistochemistry they were recognized from birth. Morphometrical differences were found between the intestinal sections at each age studied, and within each section during the first weeks of life. In all developmental stage, the highest number of PC was observed in the duodenum of 13 days old guinea pigs. Our results confirm the presence of PC in the small intestine of guinea pigs from birth. Anat Rec, 297:856–863, 2014. © 2014 Wiley Periodicals, Inc.
Controlling complement resistance in cancer by using human monoclonal antibodies that neutralize complement‐regulatory proteins CD55 and CD59

Expression of the complement‐regulatory proteins (CRP) CD46, CD55 and CD59 represents a strategy used by tumor cells to evade complement‐dependent cell cytoxicity stimulated by monoclonal antibodies. We have isolated two single‐chain variable fragments (scFv) to CD55 and CD59 from a human phage‐display library and from these scFv we have produced two miniantibodies (MB), MB‐55 (against CD55) and MB‐59 (against CD59), containing the human hinge–CH2–CH3 domains of IgG1. The specificity of the two MB for the corresponding CRP was assessed by ELISA using purified CD46, CD55 and CD59. MB‐55 and MB‐59 neutralized the inhibitory activity of CD55 and CD59, respectively, restoring the complement‐mediated lysis of sheep and guinea pig erythrocytes that was otherwise inhibited by the two CRP. FACS analysis revealed binding of MB‐55 and MB‐59 to the lymphoma cell line Karpas 422. The two MB induced a two‐fold increase in the complement‐dependent killing of these cells stimulated by Rituximab, a chimeric anti‐CD20 monoclonal antibody. Transfection of HEK293T cells with vectors encoding MB‐55 or MB‐59 markedly reduced the expression of CD55 and CD59. We conclude that the human antibodies MB‐55 and MB‐59 may represent a therapeutic tool to increase the complement‐dependent killing activity of Rituximab in the treatment of non‐Hodgkin's lymphoma.
Patient assessed symptoms are poor predictors of objective findings. Results from a cross sectional study in patients treated with radiotherapy for pharyngeal cancer

Introduction. The aim of the study was to assess the value of the EORTC questionnaires C30 and H&N35, as an instrument for the study of side effects. Patients and methods. We invited all recurrence free patients, treated with radical radiotherapy for pharyngeal cancer between 1998 and 2002 at our institution, to participate in the study. Data was retrieved using questionnaires, functional endoscopic evaluation of swallowing, dental examination with orthopantomography and saliva flow measurements. Thirty-five (55% of invited) participated. Results. Side effects were omnipresent and often severe. The value of patient assessed symptom scores to predict equivalent objective changes was varied: We found a sensitivity of 0.59–0.93, specificity of 0.40–0.81, positive predictive value of 0.28–0.81 and a negative predictive value of 0.46–0.94. Conclusion. The questionnaire should be used to retrieve information on subjective side effects and objective examination should be used for objective changes. One cannot conclude from one to the other.
Organic agricultural production on family farms in Croatia

ABSTRACT The Croatian organic products market is not developed as it is in economically more developed European Union (EU) countries. There are 2,319 registered organic producers on a total area of 50,054 ha. It was assumed that producers’ motives of organic products are predominantly noneconomic and that they sell most of products through direct sales channels and have positive attitudes toward producers’ associations. A survey was conducted with organic producers in Northwest Croatia. They (72.7%) switched from conventional to organic farming due to noneconomic motives. Due to an unorganized distribution network, products placement in markets mainly takes place locally (71.4%). Most producers are cooperating but in an informal way.
The Influence of Quality of Work Life on Work Performance

Abstract In the dynamic time in which we live, job and life satisfaction have emerged as major issues in the field of organizational behavior. Considering that the goal of every organization is to prosper and maintain its competitiveness, employers are forced to pay attention to employees’ job performance, which is positively related to the quality of their working life. This could be attributed to the fact that employees who attain high levels of job and life satisfaction tend to be highly motivated and work more efficiently. Consequently, starting from a secondary analysis based on data provided by the European Working Condition Survey, the present paper aims at drawing a picture of the way employed population in Romania relates to different quality components of work life.
Categories and continua of destructive and constructive marital conflict tactics from the perspective of U.S. and Welsh children.

Categories and continua of parents' marital conflict tactics based on multiple, conceptually grounded criteria were tested. Participants were 175 U.S. children, ages 8-16 years (88 boys, 87 girls) and 327 Welsh children, ages 11-12 years (159 boys, 168 girls). Children's responses (affective, cognitive, behavioral) to analog presentations of 10 everyday marital conflict tactics enacted by fathers or mothers showed substantial variation as a function of tactic used. Orderings of conflict tactics on the various response criteria varied as a function of moderators, particularly the gender of the parent expressing the conflict tactic. Conflict tactics were classified as either constructive or destructive according to criteria derived from the emotional security hypothesis. Except for calm discussion, classifications did not change regardless of cultural group, parent gender, or child age or gender. Recommendations for negotiating everyday marital conflict for the children's sake are discussed.
Acute myeloid leukemia does not deplete normal hematopoietic stem cells but induces cytopenias by impeding their differentiation

Acute myeloid leukemia (AML) induces bone marrow (BM) failure in patients, predisposing them to life-threatening infections and bleeding. The mechanism by which AML mediates this complication is unknown but one widely accepted explanation is that AML depletes the BM of hematopoietic stem cells (HSCs) through displacement. We sought to investigate how AML affects hematopoiesis by quantifying residual normal hematopoietic subpopulations in the BM of immunodeficient mice transplanted with human AML cells with a range of genetic lesions. The numbers of normal mouse HSCs were preserved whereas normal progenitors and other downstream hematopoietic cells were reduced following transplantation of primary AMLs, findings consistent with a differentiation block at the HSC–progenitor transition, rather than displacement. Once removed from the leukemic environment, residual normal hematopoietic cells differentiated normally and outcompeted steady-state hematopoietic cells, indicating that this effect is reversible. We confirmed the clinical significance of this by ex vivo analysis of normal hematopoietic subpopulations from BM of 16 patients with AML. This analysis demonstrated that the numbers of normal CD34+CD38− stem-progenitor cells were similar in the BM of AML patients and controls, whereas normal CD34+CD38+ progenitors were reduced. Residual normal CD34+ cells from patients with AML were enriched in long-term culture, initiating cells and repopulating cells compared with controls. In conclusion the data do not support the idea that BM failure in AML is due to HSC depletion. Rather, AML inhibits production of downstream hematopoietic cells by impeding differentiation at the HSC–progenitor transition.
Using Genomic Resources to Guide Research Directions. The Arabinogalactan Protein Gene Family as a Test Case1

Arabinogalactan proteins (AGPs) are extracellular hydroxyproline-rich proteoglycans implicated in plant growth and development. The protein backbones of AGPs are rich in proline/hydroxyproline, serine, alanine, and threonine. Most family members have less than 40% similarity; therefore, finding family members using Basic Local Alignment Search Tool searches is difficult. As part of our systematic analysis of AGP function in Arabidopsis, we wanted to make sure that we had identified most of the members of the gene family. We used the biased amino acid composition of AGPs to identify AGPs and arabinogalactan (AG) peptides in the Arabidopsis genome. Different criteria were used to identify the fasciclin-like AGPs. In total, we have identified 13 classical AGPs, 10 AG-peptides, three basic AGPs that include a short lysine-rich region, and 21 fasciclin-like AGPs. To streamline the analysis of genomic resources to assist in the planning of targeted experimental approaches, we have adopted a flow chart to maximize the information that can be obtained about each gene. One of the key steps is the reformatting of the Arabidopsis Functional Genomics Consortium microarray data. This customized software program makes it possible to view the ratio data for all Arabidopsis Functional Genomics Consortium experiments and as many genes as desired in a single spreadsheet. The results for reciprocal experiments are grouped to simplify analysis and candidate AGPs involved in development or biotic and abiotic stress responses are readily identified. The microarray data support the suggestion that different AGPs have different functions.
Reconfigurable Antenna-Based Space-Shift Keying (SSK) for MIMO Rician Channels

In this work, we use the concept of the new emerging technology of reconfigurable antennas (RAs) in an effort to improve the performance of space shift keying (SSK). Indeed, the reconfigurable properties of RAs can be used as additional degrees of freedom to enhance the performance of SSK in terms of throughput, system complexity, and error performance. In this context, considering correlated and nonidentically distributed Rician fading channels, we propose a number of SSK-RA schemes using SSK with antenna-state selection while taking advantage of the effect of RAs on the multipath propagation channel. More specifically, based on the variation of the Rician K-factor and the correlation coefficients with different antenna states, the proposed schemes jointly optimize the fading and correlation parameters to enhance SSK's performance. In this paper, we analyze the performance of the proposed SSK-RA schemes over Rician fading channels in terms of average spectral efficiency (ASE) and bit error rate (BER). We also provide several simulation examples through which we corroborate these analytical results. The proposed schemes are shown to enhance the performance of SSK both in terms of ASE and BER. For the same ASE, compared to that of SSK, not only do the proposed SSK-RA schemes provide much better error performance, they also reduce the implementation cost and the overall system complexity considerably.
Crise d'identité et devenir professionnel des étudiants qui sont engagés dans un doctorat en éducation/formation. Une approche comparative franco-argentine

Cette communication s'articule autour de deux axes : la problematique de l'identite, liee a celle de la professionnalisation dans le domaine de la formation et d'insertion professionnelle. La professionnalisation d'individus exige la mise en place des nouveaux dispositifs ; d'autre part, les conditions d'exercice dans le monde du travail ont change et l'insertion professionnelle constitue chaque fois de plus un probleme complexe. Les liens entre parcours personnels, de formation et professionnels deviennent un axe de preoccupation. Notre objectif est de connaitre les facteurs qui influent sur la reussite professionnelle des doctorants (francais et argentins) et leurs representations sur la valeur d'une formation doctorale et des chances dans l'avenir. Population : des doctorants du Cnam et de l'Universidad de Cuyo (deux filieres, 2005-2009). La methodologie a ete qualitative et quantitative. Les resultats nous ont permis de saisir le noyau central de leurs representations sociales associees a l'identite professionnelle.
Sectoral cognitive skills, R&D, and productivity: a cross-country cross-sector analysis

ABSTRACT We focus on human capital measured by skills and analyse its relationship with R&D investments and productivity across 12 OECD economies and 17 industries. We compute a measure of sectoral human capital defined as the average cognitive skills of the workforce in each country-sector combination. The variation in labour productivity that can be explained by human capital is remarkably large when measured by the sectoral skills, whereas it appears statistically insignificant when measured by the sectoral school attainment. This suggests that using measures of sectoral cognitive skills can represent a major step forward in any future sectoral growth accounting exercise.
The Genetic Landscape of the Childhood Cancer Medulloblastoma

Genomic analysis of a childhood cancer reveals markedly fewer mutations than what is typically seen in adult cancers. Medulloblastoma (MB) is the most common malignant brain tumor of children. To identify the genetic alterations in this tumor type, we searched for copy number alterations using high-density microarrays and sequenced all known protein-coding genes and microRNA genes using Sanger sequencing in a set of 22 MBs. We found that, on average, each tumor had 11 gene alterations, fewer by a factor of 5 to 10 than in the adult solid tumors that have been sequenced to date. In addition to alterations in the Hedgehog and Wnt pathways, our analysis led to the discovery of genes not previously known to be altered in MBs. Most notably, inactivating mutations of the histone-lysine N-methyltransferase genes MLL2 or MLL3 were identified in 16% of MB patients. These results demonstrate key differences between the genetic landscapes of adult and childhood cancers, highlight dysregulation of developmental pathways as an important mechanism underlying MBs, and identify a role for a specific type of histone methylation in human tumorigenesis.
The Nexus of Carbon, Nitrogen, and Biodiversity Impacts from Urban Metabolism

Methodology is developed for linking the urban metabolism (UM) to global environmental stresses on the carbon (C) cycle, nitrogen (N) cycle, and biodiversity loss. UM variables are systematically mapped to the drivers of carbon, nitrogen, and biodiversity impacts. Change in mean species abundance is used as metric of biodiversity loss, by adopting the dose‐response relationships from the GLOBIO model. The main biodiversity drivers related to UM included here are land‐use change (LUC) and atmospheric N deposition. The methodology is demonstrated by studying the nexus for Shanghai in 2006, based on energy and soybean consumption. Results for Shanghai show a strong nexus between C, N, and biodiversity impact due to electricity consumption and energy used in manufacturing industries and construction. Prioritization of the shift away from coal energy will therefore lead to lowering the urban growth impact on all three dimensions. Road transportation, domestic aviation, and the metal industry impact only the C footprint highly, whereas district energy impacts only biodiversity loss highly, showing a weak nexus. Among the global impacts of soybean consumption in Shanghai on biodiversity loss (due to LUC only), the highest impact occurs in Uruguay (0.52%) followed by Brazil (0.05%) and Argentina (0.02%). The local impact on biodiversity loss (i.e., within China) of soybean consumption in Shanghai is 1.03%. However, the methodology and results are limited due to the partial inclusion of drivers, a carbon footprint based on carbon dioxide emissions only, and limitations of biodiversity loss models. Potential to overcome methodological limitations is discussed.
An enlarged cell wall proteome of Arabidopsis thaliana rosettes

Plant cells are surrounded by cell walls playing many roles during development and in response to environmental constraints. Cell walls are mainly composed of polysaccharides (cellulose, hemicelluloses and pectins), but they also contain proteins which are critical players in cell wall remodeling processes. Today, the cell wall proteome of Arabidopsis thaliana, a major dicot model plant, comprises more than 700 proteins predicted to be secreted (cell wall proteins—CWPs) identified in different organs or in cell suspension cultures. However, the cell wall proteome of rosettes is poorly represented with only 148 CWPs identified after extraction by vacuum infiltration. This new study allows enlarging its coverage. A destructive method starting with the purification of cell walls has been performed and two experiments have been compared. They differ by the presence/absence of protein separation by a short 1D‐electrophoresis run prior to tryptic digestion and different gradient programs for peptide separation before mass spectrometry analysis. Altogether, the rosette cell wall proteome has been significantly enlarged to 361 CWPs, among which 213 newly identified in rosettes and 57 newly described. The identified CWPs fall in four major functional classes: 26.1% proteins acting on polysaccharides, 11.1% oxido‐reductases, 14.7% proteases and 11.7% proteins possibly related to lipid metabolism.
Candidemia in major burns patients

Major burn patients have characteristics that make them especially susceptible to candidemia, but few studies focused on this have been published. The objectives were to evaluate the epidemiological, microbiological and clinical aspects of candidemia in major burn patients, determining factors associated with a poorer prognosis and mortality. We conducted a retrospective observational study of candidemia between 1996 and 2012 in major burn patients admitted to the La Fe University Hospital, Valencia, Spain. The study included 36 episodes of candidemia in the same number of patients, 55.6% men, mean age 37.33 years and low associated comorbidity. The incidence of candidemia varied between 0.26 and 6.09 episodes/1000 days stay in the different years studied. Candida albicans was the most common species (61.1%) followed by Candida parapsilosis (27.8%). Candidemia by C. krusei, C. glabrata or C. tropicalis were all identified after 2004. Central vascular catheter (CVC) was established as a potential source of candidemia in 36.1%, followed by skin and soft tissues of thermal injury (22.2%) and urinary tract (8.3%). Fluconazole was used in 19 patients (52.7%) and its in vitro resistance rate was 13.9%. The overall mortality was 47.2%, and mortality related to candidemia was 30.6%. Factors associated with increased mortality were those related to severe infection and shock. CVC was the most usual focus of candidemia. Fluconazole was the most common antifungal drug administered. The management of candidemia in major burn patients is still a challenge.
Recent advancement of triazole derivatives and their biological significance

Article is based on the different pharmacological activity of the triazole ring, from a last decade a lot of work is going on, on the triazole ring , scientists develop a lot of new compounds related to this moiety and screened them for there different pharmacological activities to get a molecule which have good pharmacological activity and lesser side effect. This review article reflects various pharmacological activities of new triazole derivatives.This triazole has shown its importance as antimicrobial, anti-inflammatory, hypoglycemic, antidepressant, antitubercular, analgesic, anti-malarial and anticancer agents.
Sturge-Weber Syndrome: Age of Onset of Seizures and Glaucoma and the Prognosis for Affected Children

Data were obtained on 171 individuals with Sturge-Weber syndrome via questionnaire and medical records. The age of the study group ranged from 2 months to 59 years; the median was 8 years. In addition to the facial location of port-wine stains in the areas of the trigeminal dermatomes present in 170 patients, 45% also had extracranial port-wine stains over the torso and/or extremities, and 17% had other vascular or pigmentary lesions. Seizures were present in 80% of all patients (87% of those with bilateral and 71% of those with unilateral port-wine stains); in all but one case, seizures were associated with port-wine stains in V 1 alone or V1 and V2 trigeminal dermatomes location. The age of onset of seizures ranged from birth to 23 years; 75% had onset of seizures before 1 year of age; these children had an 83% incidence of developmental and academic problems. Fifty-eight percent showed early developmental delay and required special education classes. The rate of retardation showed a decreasing tendency with increasing age of onset of seizures; of the children without seizures, only 6% had developmental delay and 11% required special education classes. Glaucoma was present in 48% of patients (67% unilateral and 33% bilateral). Of all patients with glaucoma, 92% had port-wine stains in both V1 and V2 dermatomes and 8% only in V1. The laterality of glaucoma did not correspond to the trigeminal distribution of the port-wine stains in all instances. Glaucoma was diagnosed during the 1st year of life in 61% and by 5 years in 72%; one patient did not have onset of symptoms until 38 years. The results of our data can serve as a guide for estimating relative risk figures for seizures, glaucoma, and mental retardation in children with Sturge-Weber syndrome. (J Child Neurol 1995;10:49-58).