Miracle-dz/UniFAR-FTUs huggingface dataset:
Luminous and Obscured Quasars and Their Host Galaxies

The most heavily-obscured, luminous quasars might represent a specific phase of the evolution of actively accreting supermassive black holes and their host galaxies, possibly related to mergers. We investigated a sample of the most luminous quasars at $z\approx 1-3$ in the GOODS fields, selected in the mid-infrared band through detailed spectral energy distribution (SED) decomposition. The vast majority of these quasars (~80%) are obscured in the X-ray band and ~30% of them to such an extent, that they are undetected in some of the deepest (2 and 4 Ms) Chandra X-ray data. Although no clear relation is found between the star-formation rate of the host galaxies and the X-ray obscuration, we find a higher incidence of heavily-obscured quasars in disturbed/merging galaxies compared to the unobscured ones, thus possibly representing an earlier stage of evolution, after which the system is relaxing and becoming unobscured.
Two Cases of Chloroquine Psychosis

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Workplace conditions, socioeconomic status, and the risk of mortality and acute myocardial infarction: the Kuopio Ischemic Heart Disease Risk Factor Study.

OBJECTIVES This study investigated whether the association between workplace conditions and the risk of all-cause and cardiovascular mortality and acute myocardial infarction differed by socioeconomic status. METHODS Prospective data were used to examine these associations in 2297 Finnish men, with adjustment for prevalent diseases and biological, behavioral, and psychosocial covariates, and stratified by employment status and workplace social support. RESULTS Elevated age-adjusted relative hazards for all-cause mortality were found for men who reported high demands, low resources, and low income; high demands, high resources, and low income; and low demands, high resources, and low income. Similar patterns were found for cardiovascular mortality. In contrast, elevated age-adjusted relative hazards for acute myocardial infarction were observed only in men who reported high demands, low resources, and low income. These results did not differ by level of workplace social support or employment status. CONCLUSIONS The negative effects of workplace conditions on mortality and of myocardial infarction risk depended on income level and were largely mediated by known risk factors.
Protein biochip array technology for cytokine profiling predicts etanercept responsiveness in rheumatoid arthritis

In rheumatoid arthritis (RA) there are currently no useful indicators to predict a clinical response to tumour necrosis factor‐α (TNF‐α) blockade. The purpose of this study was to determine the role of peripheral blood cytokine profiling in differentiating between a good versus poor response to etanercept in RA. Peripheral blood samples were collected at baseline and at 3 months from 33 patients with active disease who were treated twice weekly by etanercept therapy. Responders are defined by the presence of three of four American College of Rheumatology criteria: ≥20% decrease in C‐reactive protein (CRP), visual analogue score of disease activity, erythrocyte sedimentation rate and improvement of the disease activity score (28; four values) by ≥1·2 obtained at 3 months. Twelve cytokines were measured from serum collected on days 0 and 90 by proteomic array (protein biochip array, Investigator Evidence, Randox France), including interleukin (IL)‐6, TNF‐α, IL‐1a, IL‐1b, IL‐2, IL‐8, interferon‐γ, IL‐4, IL‐10, monocyte chemoattractant protein (MCP)‐1, epidermal growth factor (EGF) and vascular endothelium growth factor. Our results showed that high serum levels of MCP‐1 and EGF were associated with a response to etanercept. In addition, the increase of two combined parameters CRP and EGF was predictive of a response to etanercept treatment at 3 months (sensitivity: 87·5% and specificity: 75%, accuracy: 84·4%). These findings suggest that cytokine profiling by proteomic analysis before treatment initiation may help to identify a responder patient to TNF‐α blocking agents in RA.
Predicting Online Purchase Conversion for Retargeting

Generally 2% of shoppers make a purchase on the first visit to an online store while the other 98% enjoys only window-shopping. To bring people back to the store and close the deal, "retargeting" has been a vital online advertising strategy that leads to "conversion" of window-shoppers into buyers. As such retargeting is more effective as a focused tool, in this paper, we study the problem of identifying a conversion rate for a given product and its current customers, which is an important analytics metric for retargeting process. Compared to existing approaches using either of customer- or product-level conversion pattern, we propose a joint modeling of both level patterns based on the well-studied buying decision process. To evaluate the effectiveness of our method, we perform extensive experiments on the simulated dataset generated based on a set of real-world web logs. The evaluation results show that conversion predictions by our approach are consistently more accurate and robust than those by existing baselines in dynamic market environment.
Spaces of rational curves on complete intersections

Abstract We prove that the space of smooth rational curves of degree $e$ on a general complete intersection of multidegree $(d_1, \ldots , d_m)$ in $\mathbb {P}^n$ is irreducible of the expected dimension if $\sum _{i=1}^m d_i \lt (2n+m+1)/3$ and $n$ is sufficiently large. This generalizes a result of Harris, Roth and Starr [Rational curves on hypersurfaces of low degree, J. Reine Angew. Math. 571 (2004), 73–106], and is achieved by proving that the space of conics passing through any point of a general complete intersection has constant dimension if $\sum _{i=1}^m d_i$ is small compared to $n$.
Anti-Love Biotechnology: Was It Not Better to Have Loved and Lost Than Never to Have Loved at All?

In their article, Brian Earp, Olga Wudarczyk, Anders Sandberg, and Julian Savulescu (2013) provide a challenging argument on the prioritization of reason over emotions: If current biotechnology gave us the opportunity to interfere with “distorted” versions of our emotions through chemical alterations (anti-love drugs) that would set our brain “straight”—and, most importantly, free—why should we not use them to help interrupt unhealthy relationships? Not only could the use of anti-love biotechnology be justified, but in some instances it could be even morally required. “That is, in some cases, to deny its use would be inhumane” (Earp et al. 2013, 6) I must admit that when considering cases of domestic violence as manifestations of severely unhealthy relationships, I found myself inclined to agree (as would many others) with the suggested implementation of anti-love pills aimed at “cooling off” the emotional connection between Bonnie (the abused) and Rob (the abuser) as a morally sound solution. However, even if very tempted when considering such examples, the social consequences of such an innovative way of dealing with our structural incapability to deal with our emotions in a fully rational manner are more worrying. I can only admire the authors’ boldness to publicly speculate over the implementation of available (or nearly available) drugs that could drastically change our society, and it is precisely in this spirit that I want to move my criticism toward the possibility of morally justifying the implementation of any anti-love drugs; I suggest that prohibiting their use can indeed be considered humane. One main concern is that the authors’ argument seems to be exposed to the same critiques moved in other contexts regarding human enhancement (Garasic 2012; Sparrow 2011): The level of autonomy assumed in the semihypothetical scenario described does not sufficiently take into account the biopolitical dimension of the issue. In other words, focusing on how to adjust a single case might end up producing more damage than benefit in wider society. Although Earp and colleagues specify their focus on individual, voluntary use of anti-love biotechnology, the overall impact of the implementation of such drugs should be also considered from a social, collective perspective. Notably, when discussing the permissibility of using the anti-love drugs in cases of homosexual love, the interconnection between the choices of an individual and her surroundings has been taken into
Oliver-Sharpey Lectures ON THE NATURE OF FLUTTER AND FIBRILLATION OF THE AURICLE

LECTURE I. -AURICULAR FLUTTER. : MR. PRESIDENT,-May I first tlhankl you, Sir, and the College which you r-epresent for the honour you do meI in appointing me to this lectureship lectursipfounded to promote jiysib4gi&calaesearch by observation and experiment ana' to ehcourage tle application of physiological knowledge to the prevention and cure of disease; a lectureship f(1LI fcun.ded( tQ commenmorate \\ II great physiologist, and founded by a physician whi'ose wQrkin this very 11eXldis8 kIo'wn to an'd admired by all of ns. The request which you :bave nade,' and wlhichbI have: gratefully accepted, hias come at a moment which to mna is opportune. This lecturesliip carries Y with it a responsibility of no little weliti no lec. FIt. I. -A diagram illustrating the a,throegh a rintg ol muscle ars a resutI tireshiip could possess a portion of the ring represents thLe ref more serious or far-seeing its progress through the ring till it purpose tllanq tLle weldin' figutre shows its subsidence.
Template Directed Growth of Nb doped SrTiO3 using Pulsed Laser Deposition

Oxide materials display a wide range of physical properties. Recently, doped complex oxides have drawn considerable attention for various applications including thermoelectrics. Doped complex oxide materials have high Seebeck coefficients (S) and electrical conductivities (σ) comparable to other doped semiconductors but low thermoelectric figure of merit ZT values due to their poor thermal conductivities. For example, niobium doped strontium titanate (SrNbxTi1-xO3 or simply Nb:STO) has a power factor comparable to that of bismuth telluride. Semiconductor nanostructures have demonstrated a decrease in thermal conductivity (κ) resulting in an increase in the thermoelectric figure of merit (ZT). Nanostructures of doped oxides like niobium doped strontium titanate, may also lead to decreased κ and a corresponding increase in ZT. The major impediment to nanostructured oxide thermoelectric materials is the lack of suitable fabrication techniques for testing and eventual use. Electron Beam Lithography (EBL) was used to pattern poly-methyl-methacrylate (PMMA) resists on undoped single crystalline SrTiO3 (STO) substrates which were then filled with Nb:STO using Pulsed Laser Deposition (PLD) at room temperature. This technique produced nanowires and nanodots with critical dimensions below 100 nm, and a yield of approximately 95%. In addition to scanning electron microscopy and atomic force microscopy morphological studies of the patterned oxide, thin film analogues were used to study composition, crystallinity and electrical conductivity of the material in response to a post deposition heat treatment. Since the thin films were grown under similar experimental parameters as the oxide nanostructres, the patterned oxides are believed to be stoichiometric and highly crystalline. The study found that using a combination of EBL and PLD, it is possible to produce highly crystalline, doped complex oxide nanostructures with excellent control over morphology. Furthermore, the technique is applicable to nearly all
Association between excessive Internet use and oral health behaviors of Korean adolescents: A 2015 national survey.

OBJECTIVE This study aimed to investigate excessive Internet use's (EIU's) association with oral health behaviors among Korean adolescents. BASIC RESEARCH DESIGN This cross-sectional study was based on the 11th Korea Youth Risk Behavior Web-based Survey (2015). PARTICIPANTS 68,043 school students aged 13-18 years (35,204 boys and 32,839 girls). Data on, 45,271 (23,354 males and 21,917 females using the Internet on weekdays) and 49,324 (27,448 males and 21,876 females using the Internet on weekends) were analyzed after excluding questionnaires with missing values. MAIN OUTCOME MEASURES The key variables were oral health behaviors (tooth-brushing frequency and tooth brushing after lunch at school, and preventive oral health behaviors), EIU (hours of Internet use on weekdays and weekends, excluding use for academic purposes). RESULTS Compared to the general groups, the odds ratio (OR) for less tooth-brushing was 4.04 (95%CI=2.990-5.459) and 3.55-fold higher (95% CI=2.703-4.659) in the high-risk groups for weekday and weekend EIU, respectively. For post-lunch tooth-brushing, compared to the general groups, the OR for less tooth-brushing was 1.7-fold higher in the high-risk groups for EIU during weekdays and weekends. The OR for no preventive behavior was significantly higher in the high-risk groups than in the potential-risk and general groups. CONCLUSIONS Policies moderating adolescents' EIU may enable appropriate oral health behaviors.
DEMOGRAPHICS OF TUBERCULOSIS IN DISTRICT MANSEHRA.

BACKGROUND Tuberculosis is one of the leading causes of morbidity and mortality across the globe. Pakistan is one of the 22 high tuberculosis burden countries of the world sharing more than 80% of the global burden of tuberculosis. METHODS This study was a retrospective case-based study that analyzed secondary data obtained from TB-03 form at the office of the District Tuberculosis Control Officer (DTO), Mansehra. Data was entered into SPSS-20 and analysed. RESULTS A total of 625 patients with a mean age of 32.1 ± 19.1 years were registered at the DTO office during the year 2013. Most of the patients were female (57%) as compared to males (43%). The most common treatment outcome was "treatment completed", recorded against 56% of the patients. The proportion of patients declared "cured" at the end of the treatment was 236 (37.8%). There were only 4 (0.64%) cases of treatment failure during 2013. CONCLUSION Despite falling incidence of tuberculosis and mortality across the globe, tuberculosis is still a major determinant of disease in our society. Aggressive case detection and treatment is needed to manage this disease.
Prevalence, awareness, treatment and control of hypertension in urban poor communities in Accra, Ghana

Background: Hypertension is a major public health problem in many sub-Saharan African countries including Ghana, but data on urban poor communities are limited. The aim of this study was therefore to assess the prevalence, awareness, management and control of hypertension among a young adult population in their reproductive ages living in urban poor communities in Accra. Methods: Cross-sectional, population-based survey of 714 young adults in their reproductive ages (women aged 15–49 years, men aged 15–59 years) living in three urban poor suburbs of Accra, Ghana. Results: The overall prevalence of hypertension in all three communities was 28.3% (women 25.6% and men 31.0%). Among respondents who had hypertension, 7.4% were aware of their condition; 4% were on antihypertensive medication while only 3.5% of hypertensive individuals had adequate blood pressure (BP) control (BP <140/90 mmHg). The level of awareness and treatment was lower in men than in women (3.1 and 1.3% for men and 11.9 and 6.5% for women, respectively). Among individuals with hypertension, the rate of control was higher among women than among men (5.0 and 2.1%, respectively). Conclusion: Although about a quarter of the young adult population in these low-income communities of Accra have hypertension, the levels of awareness, treatment and control are abysmally low. We recommend community-specific primary and secondary prevention interventions that draw on existing resources, specifically implementing cardiovascular disease (CVD) interventions in faith-based organizations and task-shifting CVD care through the national Community-based Health Planning and Services (CHPS) programme.
Mechanism of Pigeon Liver Malic Enzyme

the slow, magnesium-dependent reduction of oxalacetate and conversion of L-malate to L-lactate in the presence of TPNH and TPN, respectively, with TPN acting in a catalytic manner. a optimum of 6.5 to 6.8 and a Michaelis constant of 5.52 mM for pyruvate.
Antioxidants and Gabapentin Prevent Heat Hypersensitivity in a Neuropathic Pain Model

ABSTRACT Background: The involvement of voltage-dependent calcium channels and reactive oxygen species in the pathophysiology of neuropathic pain might justify the preventative administration of antioxidant enzymes, at low doses, in combination with gabapentin (GaP) to maximize its analgesic effect in an experimental model of neuropathic pain in rats. Methods: This work investigated the analgesic effects of these drugs, alone or in combination, by intraperitoneal administration for three consecutive days before (Series I) or after (Series II) a peripheral neuropathy induced by left sciatic nerve ligation. A prospective randomized study was conducted using 96 Wistar rats (50 males and 46 females). Mechanical hypersensitivity was measured with a dynamic plantar anesthesiometer. A hot plate analgesia meter calculated the thermal sensitivity. Side effect profiles for drug combinations were evaluated with a conventional scale to assess levels of sedation interfering with postural control and righting reflexes. Results: Preinjury administration (Series I) of GaP alone prevented the development of mechanical hypersensitivity at the nerve-damage hind paw. When GaP was administered concurrently with superoxide dismutase and catalase, its preventive analgesic effect did not increase. Antioxidants administered alone were completely ineffective at modulating the mechanical or thermal hypersensitivity. When treatments were only delivered following surgery (Series II), only the group receiving combined GaP and antioxidants treatment prior to nerve injury showed higher thermal thresholds from postsurgery days 7–30. Conclusions: These results suggest that preventive antioxidants in combination with GaP provided a synergistic suppression of thermal hypersensitivity that GaP alone cannot produce.
Blood biochemical parameters measured during the periparturient period in cows of Holstein and Fleckvieh breeds differing in production purpose

The aim of this study was to compare the metabolic status of dairy and dual-purpose cows kept in a single herd under identical management conditions. Milk yield and blood biochemical parameters were examined during the periparturient period in Holstein (H) and Fleckvieh (F) cows. Blood samples were first taken on average 14 days prior to the expected date of calving, next in the peripartal period (1–4 days postpartum), and then at weekly intervals (together with milk samples) until the end of the experiment (8 weeks postpartum). Milk yields were higher in H cows from the second week after calving whereas milk protein content always was higher in F cows over the whole experimental period. The level of metabolic stress determined using blood concentrations of nonesterified fatty acids (NEFA), β-hydroxybutyrate (BHB), triglycerides, and cholesterol was similar in both breeds. The proportion of animals with concentrations of NEFA and BHB above thresholds indicating increased risk of negative energy balance and subclinical ketosis was higher in the H breed in the first 2 weeks after calving. This corresponds with numerically higher concentrations of NEFA and BHB in H cows. Changes in the protein status of animals generally reflected the development in energy metabolism parameters. Serum total protein, albumin,and urea levels were similar in the two breeds. Total globulin was higher in H cows than in F cows in weeks 3, 4, and 5 after calving, and the albumin-to-globulin ratio was lower in H cows than in F cows in weeks 2, 3, and 4 after calving. In conclusion, although the onset of changes in key metabolic parameters was rather faster and more pronounced in the H breed, similar dynamics in the development of these parameters indicated similar levels of adaptive performance and body energy mobilization processes in the two breeds.
Modelling of Downhill Timber Skidding: Bigger Load – Bigger Slope

Skidder mobility during timber extraction is defined by: 1) basic dimensional features of the vehicle, 2) ability to overcome obstacles during movement, 3) traction performance and 4) environmental soundness. Traction performance depends on the ground conditions (soil bearing capacity) and the total effect of all forces on the vehicle. In downhill skidding, the skidder is under great influence of parallel component of forces, adhesion weight and longitudinal terrain slope, which combined result in negative traction force, torque and thrust force. When the horizontal component of rope force is equal to zero i.e. the moment when the weight of the load and resistance to traction are in equilibrium, the slope angle α is a function of load mass distribution factor and skidding resistance factor. This is a »turning point« that can be defined as a critical slope because the load starts to push the vehicle downhill, which results in negative horizontal component of rope force. Depending on skidder Ecotrac 120V dimensional features, centre of gravity, load mass distribution factor, skidding resistance factor of previous research, five different loads were analyzed (1 to 5 tonnes) in order to define the critical slope angle for each of them. Critical slope for downhill skidding of 1 tonne timber is on longitudinal slope of –26%, for 2 tonne timber on –30%, 3 tonne timber on –34%, 4 timber on – 38% and for 5 tonne timber on –43% of terrain longitudinal slope. Even though skidding bigger load increases vehicle mobility to even greater slope angles, the most important in downhill skidding, is to avoid blocking of the wheels, which will lead to a complete vehicle slippage and the driver must be constantly aware of that fact. The general recommendation should be that skidding small loads (1 to 3 tonnes) downhill is suitable for smaller longitudinal terrain slopes (up to maximum –34%), while the heavier the load, the further down the slope the skidder can go. The load of 5 tonnes »anchors« the skidder better and therefore it can go on terrain slopes up to –43%, during which less traction force is used (torque is used for braking) and skidder pulls the load by its own weight. It can be concluded that extending the operating range of skidder onto steeper slopes with heavier loads has the potential to decrease harvesting costs and increase productivity.