Miracle-dz/UniFAR-FTUs huggingface dataset:
Patient-ventilator trigger asynchrony in prolonged mechanical ventilation.

STUDY OBJECTIVE To investigate patient-ventilator trigger asynchrony (TA), its prevalence, physiologic basis, and clinical implications in patients requiring prolonged mechanical ventilation (PMV). STUDY DESIGN Descriptive and prospective cohort study. SETTING Barlow Respiratory Hospital (BRH), a regional weaning center. PATIENTS Two hundred consecutive ventilator-dependent patients, transferred to BRH over an 18-month period for attempted weaning from PMV. METHODS AND INTERVENTIONS Patients were assessed clinically for TA within the first week of hospital admission, or once they were in hemodynamically stable condition, by observation of uncoupling of accessory respiratory muscle efforts and onset of machine breaths. Patients were excluded if they had weaned by the time of assessment or if they never achieved hemodynamic stability. Ventilator mode was patient triggered, flow control, volume cycled, with a tidal volume of 7 to 10 mL/kg. Esophageal pressure (Peso), airway-opening pressure, and airflow were measured in patients with TA who consented to esophageal catheter insertion. Attempts to decrease TA in each patient included application of positive end-expiratory pressure (PEEP) stepwise to 10 cm H2O, flow triggering, and reduction of ventilator support in pressure support (PS) mode. Patients were followed up until hospital discharge, when outcomes were scored as weaned (defined as >7 days of ventilator independence), failed to wean, or died. RESULTS Of the 200 patients screened, 26 were excluded and 19 were found to have TA. Patients with TA were older, carried the diagnosis of COPD more frequently, and had more severe hypercapnia than their counterparts without TA. Only 3 of 19 patients (16%), all with intermittent TA, weaned from mechanical ventilation, after 70, 72, and 108 days, respectively. This is in contrast to a weaning success rate of 57%, with a median (range) time to wean of 33 (3 to 182) days in patients without TA. Observation of uncoupling of accessory respiratory muscle movement and onset of machine breaths was accurate in identifying patients with TA, which was confirmed in all seven patients consenting to Peso monitoring. TA appeared to result from high auto-PEEP and severe pump failure. Adjusting trigger sensitivity and application of flow triggering were unsuccessful in eliminating TA; external PEEP improved but rarely led to elimination of TA that was transient in duration. Reduction of ventilator support in PS mode, with resultant increased respiratory pump output and lower tidal volumes, uniformly succeeded in eliminating TA. However, this approach imposed a fatiguing load on the respiratory muscles and was poorly tolerated. CONCLUSION TA can be easily identified clinically, and when it occurs in the patient in stable condition with PMV, is associated with poor outcome.
Applying an extended theory of planned behavior to predict posthumous organ donation intentions

Using a theory of planned behavior (TPB) perspective, individual intentions to register and discuss the organ donation decision with significant others were examined. In addition to standard TPB variables (attitude, subjective norm, and perceived behavioral control [PBC]), selfidentity and moral norm were incorporated into the TPB as predictors. Australian university students (N = 303) completed a survey comprising standard and additional TPB constructs. Separate analyses were conducted for both registered and non-registered participants. In general, results provide support for the extended TPB model in predicting intentions to register and discuss the donation decision with the exceptions that self-identity did not predict discussion intentions for either registered or non-registered participants and PBC did not predict discussion intentions for non-registered participants.
Sentiment analysis for reviews of restaurants in Myanmar text

Sentiment analysis is the analysis of the feeling such as attitude, emotion and opinion. Sentiment analysis on English Language has become large and popular field of research area with many commercial applications. Researchers from different countries want to build sentiment analysis systems in their own language. This paper proposes the creation of Myanmar sentiment lexicon for food and restaurant domain and analyses the Myanmar text reviews of customers using lexicon-based sentiment analysis for the recommendation. To our knowledge, this is the first work for sentiment analysis of Myanmar text comments. The first challenge is the absence of annotated data and sentiment lexicons. In this paper, we address this approach to sentiment analysis for Myanmar Language and generate the context-independent sentiment rules for Myanmar Language.
Evaluation of CAC Methods under non-Poisson arrival traffic in cellular networks

The mean remaining time (MRT) and guard channel with queue (GCQ) call admission control (CAC) methods are evaluated in the context of non-Poisson arrival traffic conditions. The MRT scheme uses statistical estimates of the traffic profile when admitting/rejecting new calls to meet predefined QoS levels. MRT provides network operators with a wide working interval. It is simple to compute and easy to implement, and it complies with criteria of relevance in choosing a CAC policy. The GCQ scheme has been studied extensively because of its high practical value, but always under the assumption of Poisson-distributed call arrivals. Analytical studies and field measurements show that the arrival process in wireless cellular networks is not memoryless. Therefore, the main goal of the research reported in this paper is to evaluate the performances of the two call admission control methods under realistic traffic scenarios. Our results show that handover performance is highly dependent on inter-arrival times and on the channel holding time when arrival traffic is smooth. These results have important implications for cellular network dimensioning.
Effect of treatment with methicillin and gentamicin in a new experimental mouse model of foreign body infection

A new mouse model of foreign body infection has been developed. Intraperitoneal placement of a silicone catheter followed by injection of 10(8) Staphylococcus aureus organisms resulted in a reproducible, localized foreign body infection. The infection persisted as an intra-abdominal abscess surrounding the catheter for at least 30 days. Treatment with up to nine doses of methicillin or gentamicin or both was started 3 days after infection. The treatment showed a significant effect (P < 0.05), measured as reduction of bacteria on the foreign body, for all three regimens with a reduction of up to 2 log units, but no synergism was observed. The result of the treatment was poor, despite the facts that the local concentrations of methicillin were greater than the MIC for at least 72 h and that nine peak concentrations of gentamicin of > 13 micrograms/ml were obtained. The poor result of the treatment was not caused by development of antibiotic resistance or influenced by protein concentration, pH, or local presence in the pus of inhibitors of antibiotics. Both antibiotics showed good effects in time-kill studies in vitro on bacteria on catheters taken out of infected mice and catheters infected in vitro. During treatment, the proportion of intracellular bacteria increased in all treated mice to 60 to 75% compared with 20 to 30% in nontreated mice (P < 0.05). This indicates that intracellular survival of staphylococci may influence the outcome of the treatment in foreign body infections.
Home Prices and Household Spending

This paper explores the positive relationship betwen home prices and household spending by following a panel of Australian households over the period 2003 to 2010. There are three hypotheses put forth in the literature to explain this relationship: (1) increases in home prices raise spending via a 'traditional wealth effect'; (2) increases in home prices raise spending by easing credit constraints; and (3) home prices and spending are influenced by a common 'third factor' such as something that affects expectations regarding future income. Identifying differences in behaviour across households of different ages helps to distinguish among these hypotheses. Younger homeowners exhibit the largest home-price wealth effects, with a 3 to 4 cent increase in spending per dollar increase in home price. As young homeowners are more likely to be credit constrained, their relatively large marginal propensity to spend supports hypothesis (2) as an important determinant of the co-movement between home prices and household spending. Further, the non-response of young renters to changes in home prices argues against hypothesis (3).
Capsular polysaccharide synthesis in Streptococcus pneumoniae serotype 14: molecular analysis of the complete cps locus and identification of genes encoding glycosyltransferases required for the biosynthesis of the tetrasaccharide subunit

We have reported previously on seven genes (cps14B–H ) of Streptococcus pneumoniae serotype 14, which are part of the type 14 capsular polysaccharide synthesis (cps14 ) locus. This study describes the cloning and sequencing of the remaining part of the cps14 locus. The entire cps14 gene cluster consists of 12 open reading genes (cps14A to cps14L ), which appear to be arranged as a single transcriptional unit. The flanking regions of the cps14 locus contain vestiges of insertion elements. Moreover, a 115‐bp‐long repeated DNA element, which is also present in several other intergenic regions on the pneumococcal chromosome, has been identified upstream of cps14AAll 12 open reading frames (ORFs) were inactivated by the insertion of a tetracycline resistance cassette. The cps14A to cps14J and cps14L mutants were unencapsulated, whereas only a limited amount of capsular polysaccharide was expressed by a cps14K insertion mutant. Comparison with DNA and protein sequences available in databases allowed us to predict functions for four out of the five new cps14 gene products. The biosynthetic function of Cps14I was determined experimentally by analysis of intermediates in the synthesis of the type 14 tetrasaccharide subunit, catalysed by membrane preparations of Escherichia coli expressing pneumococcal glycosyltransferases. The cps14I gene encodes the β‐1,3‐N‐acetylglucosaminyltransferase activity necessary for the addition of the third sugar in the synthesis of the type 14 repeating unit. The activity encoded by cps14J was established using a synthetic glycosyltransferase acceptor: cps14J encodes a β‐1,4‐galactosyltransferase, which requires β‐linked GlcNAc as an acceptor. Thus, Cps14J is responsible for the addition of the last (fourth) sugar in the synthesis of the type 14 subunit.
Time reproduction in finger tapping tasks by children with attention-deficit hyperactivity disorder and/or dyslexia.

AIM Deficits in timing and sequencing behaviour in children with dyslexia and with attention-deficit hyperactivity disorder have already been identified. However many studies have not controlled for comorbidity between dyslexia and ADHD. This study investigated timing performance of children with either dyslexia or ADHD, or ADHD + dyslexia or unaffected children using a finger tapping paradigm. METHOD Four groups of children (ADHD x Dyslexia) with a total of 68 children were compared using a four factorial design with two between-subject factors (ADHD (yes/no), dyslexia (yes/no)) and two within-subject factors, inter-stimulus interval (263, 500, 625, 750, 875 and 1000 ms) and tapping condition (free tapping, synchronous tapping, and unpaced tapping). In addition the complexity of rhythm reproduction pattern (unpaced tapping) was varied (simple/complex). RESULTS No significant differences were found either in the ability of the ADHD or the dyslexia groups to sustain a self-chosen free tapping rate or to generate a stable inter-response interval either by synchronising to a signal or in reproducing a given interval without the previous pacing signal. Response averages showed the expected asynchrony and variability. In rhythm pattern reproduction the groups did not differ significantly in their ability to reproduce rhythms. However, a significant two way interaction effect between dyslexia and complexity was apparent indicating that the difference in levels of performance for simple versus complex rhythms was more pronounced for dyslexia than for the two other groups. CONCLUSION The results indicate that motor timing ability in the millisecond range below 1000 ms in children with ADHD and/or dyslexia is intact. The performance of the comorbid group was revealed to be similar to the performance of the single disorder groups, but both the dyslexic groups were relatively worse than either the ADHD-only or the unimpaired group at reproducing complex versus simple rhythms.
Selection of Hyperspectral Narrowbands (HNBs) and Composition of Hyperspectral Twoband Vegetation Indices (HVIs) for Biophysical Characterization and Discrimination of Crop Types Using Field Reflectance and Hyperion/EO-1 Data

The overarching goal of this study was to establish optimal hyperspectral vegetation indices (HVIs) and hyperspectral narrowbands (HNBs) that best characterize, classify, model, and map the world's main agricultural crops. The primary objectives were: (1) crop biophysical modeling through HNBs and HVIs, (2) accuracy assessment of crop type discrimination using Wilks' Lambda through a discriminant model, and (3) meta-analysis to select optimal HNBs and HVIs for applications related to agriculture. The study was conducted using two Earth Observing One (EO-1) Hyperion scenes and other surface hyperspectral data for the eight leading worldwide crops (wheat, corn, rice, barley, soybeans, pulses, cotton, and alfalfa) that occupy ~70% of all cropland areas globally. This study integrated data collected from multiple study areas in various agroecosystems of Africa, the Middle East, Central Asia, and India. Data were collected for the eight crop types in six distinct growth stages. These included (a) field spectroradiometer measurements (350-2500 nm) sampled at 1-nm discrete bandwidths, and (b) field biophysical variables (e.g., biomass, leaf area index) acquired to correspond with spectroradiometer measurements. The eight crops were described and classified using ~20 HNBs. The accuracy of classifying these 8 crops using HNBs was around 95%, which was ~ 25% better than the multi-spectral results possible from Landsat-7's Enhanced Thematic Mapper+ or EO-1's Advanced Land Imager. Further, based on this research and meta-analysis involving over 100 papers, the study established 33 optimal HNBs and an equal number of specific two-band normalized difference HVIs to best model and study specific biophysical and biochemical quantities of major agricultural crops of the world. Redundant bands identified in this study will help overcome the Hughes Phenomenon (or “the curse of high dimensionality”) in hyperspectral data for a particular application (e.g., biophysical characterization of crops). The findings of this study will make a significant contribution to future hyperspectral missions such as NASA's HyspIRI.
Combined Heart and Liver Transplantation: A Single-Center Experience

Background. Simultaneous combined orthotopic heart and liver transplantation (CHLTx) remains a lifesaving procedure for the patients suffering from coincident end-stage heart and liver disease and several metabolic disorders. We analyze the long-term outcome of the patients undergoing CHLTx. Methods. Between January 1992 and May 2007, 15 CHLTx were attempted at the Mayo Clinic including two combined heart, liver, and kidney transplantations and one combined heart, lung, and liver transplantations. Pretransplant cardiac diagnoses were familial amyloidosis (11), hemochromatosis (1), restrictive cardiomyopathy and cardiac cirrhosis (1), previously operated congenital heart disease and cardiac cirrhosis (1), and primary pulmonary hypertension with primary biliary cirrhosis (1). Results. Heart and liver transplantation were performed as a single combined procedure in 13 (93%) hemodynamically stable patients, and there was no perioperative mortality. Survival rates for the CHLTx recipients at 1 year, 5 years, and 10 years were 100%, 75%, and 60%, respectively, and did not differ from survival after isolated heart transplantation (93%, 83%, and 65%, respectively, P=0.39). Freedom from cardiac allograft rejection (ISHLT ≥grade 2) for CHLTx was 83% at 1 month, did not change with time, and was lower than after isolated heart transplantation (P=0.02). At the mean follow-up of 61.6±53.6 months, normal left ventricular ejection fraction and good liver allograft function were demonstrated. Three patients developed end-stage renal failure secondary to calcineurin nephrotoxicity. Conclusion. Simultaneous heart and liver transplantation is feasible and achieved excellent results for selected patients.
Simulated effects of reproductive performance on life-cycle efficiency of lamb and wool production at three lambing intervals.

A deterministic computer model of a purebreeding sheep production system was used to simulate effects on life-cycle efficiency from genetic changes in lambing rate (LB), fertility (FERT), precocity of fertility (PREC), and estrus season length (ES) under annual (Y), 4-mo (A), and 73-d (S) breeding intervals. Ewes and lambs of a 1,000-ewe flock were fed to requirement through five yr, beginning with ewe lambs at the optimal breeding season and accumulating feed input (TDN) and market lamb equivalent weight of output (EBW), including cull ewes and wool. For annual lambing, improvement in cost (TDN/EBW equivalence) per 10% increase in genetic potential was -9.8, -8.2, -1.3, and -. 8% for LB, FERT, PREC, and ES, respectively. For the A and S lambing intervals, corresponding gains in TDN efficiency were -19 for FERT and -9% for LB when ES was 72 d, but only -6 and -5% when ES was 192 d. Increasing PREC by 10% improved cost -3% under accelerated systems when ES was 72 d, but less than -1% when ES was 192 d. Cost reduction from 10% longer ES under A and S breeding intervals was greater when other reproductive performance was low (-11 and -17%) rather than high (-2 and -3%). Reduction in costs for A and S vs Y lambing intervals was greatest with long ES and was greater with low (-43 and -53%) than with high reproductive performance (-20 and -24%). When ES was 72 d, A and S intervals would reduce costs for high (-9 and -11%) but increase costs for low reproductive traits. Corresponding increases in CP/TDN required in diet would reduce gains in TDN/EBW only slightly. These results should aid in development of optimum selection criteria for stocks used for pure or rotation crossbreeding or as maternal parents of terminal crosses.
A STUDY TO IDENTIFY AND ASSESS THE RELATIONSHIP BETWEEN VENTURE CAPITALISTS (VC) AND STARTUP ENTREPRENEURS IN INDIA: FROM AN ENTREPRENEUR’S PERSPECTIVE

Venture Capital (VC) is the buzz word for an entrepreneur. Many factors are considered by VCs before deciding to invest in a particular start up. In the present competitive and advanced, business environment, start-ups are striving to attract the venture capitalists money. Certain crucial features of start-ups can severely affect the perceptions of the capitalist on their ultimate success and thereby their decision to invest. In an interesting scenario of analyzing what attracted the venture capitalists to fund the start-ups, there were major criterions that had an influence. The study has been carried out with start-up entrepreneurs of Start Up Village, Cochin, Kerala. Although the entrepreneurs portrayed the process to attract the required seed-funding as Difficult, it was still concluded that the startups of all sizes, monetary abilities, and across multiple fields, are increasingly seen to be achieving the desired seed-funding from the Venture Capitalists.
Communities, families and migration: some evidence from Cornwall

Abstract Taking its cue from Pooley and Turnbull's (1998) claim that there is no evidence of any difference in the propensity to migrate by region or settlement size, this article investigates the appropriate scale for migration research. It presents some preliminary findings from a micro-level study of three occupationally contrasting communities in Cornwall in the second half of the 19th century. Reconstructing the migration histories of a cohort of children from the 1851 census enumerators' books and making use of local and online census and civil registration index databases, the study identifies some clear differences in migration patterns and propensity at the community level. Moving from patterns to processes it argues that labour markets and occupational structures remain the most important explanatory variables structuring migration, but that these were mediated at the individual level by the influence of the family which played a key role in facilitating or deterring movement.
OS paradigms adaptation to fit new architectures

Future architectures and computer systems will be heterogeneous multi-core models, which will improve their performance, resource utilization and energy consumption. Differences between cores mean different binary formats and specific concerns when dealing with applications. The OS also needs to manage the appropriate information to schedule resources to achieve the optimal performance. In this paper we present a first approach in Linux to allow the application to give information to the OS in order to perform the best resource scheduling for the code characteristics (where it has to run). Based on the continuation model of the Mach microkernel and the device drivers of Unix-Linux system, the kernel can continue the execution flow from one core to another (i.e. from PPE to SPE in the Cell BE case). In this way, the OS can anticipate costly actions (for example, loading code or data) or reserve resources depending on task needs.
Primary care physicians’ experience with disease management programs

AbstractOBJECTIVE: To examine primary care physicians’ perceptions of how disease management programs affect their practices, their relationships with their patients, and overall patient care. DESIGN: Cross-sectional mailed survey. SETTING: The 13 largest urban counties in California. PARTICIPANTS: General internists, general pediatricians, and family physicians. MEASUREMENTS AND MAIN RESULTS: Physicians’ self-report of the effects of disease management programs on quality of patient care and their own practices. Respondents included 538 (76%) of 708 physicians: 183 (34%) internists, 199 (38%) family practitioners, and 156 (29%) pediatricians. Disease management programs were available to 285 (53%) physicians; 178 had direct experience with the programs. Three quarters of the 178 physicians believed that disease management programs increased the overall quality of patient care and the quality of care for the targeted disease. Eighty-seven percent continued to provide primary care for their patients in these programs, and 70% reported participating in major patient care decisions. Ninety-one percent reported that the programs had no effect on their income, decreased (38%) or had no effect (48%) on their workload, and increased (48%) their practice satisfaction. CONCLUSIONS: Practicing primary care physicians have generally favorable perceptions of the effect of voluntary, primary care-inclusive, disease management programs on their patients and on their own practice satisfaction.