Miracle-dz/UniFAR-FTUs huggingface dataset:
Identification and Characterization of Protease-Resistant SecA Fragments: SecA Has Two Membrane-Integral Forms

ABSTRACT We have identified and characterized the protease-resistant SecA fragments (X. Chen, H. Xu, and P. C. Tai, J. Biol. Chem. 271:29698–29706, 1996) through immunodetection with region-specific antibodies, chemical extraction, and sequencing analysis. The 66-, 36-, and 27-kDa proteolytic fragments in the membranes all start at Met1, whereas the 48-kDa fragment starts at Glu361. The overlapping of the sequences of the 66- and 48-kDa fragments indicates that they are derived from different SecA molecules. These two fragments were generated differently in response to ATP hydrolysis and protein translocation. Furthermore, the presence of membrane is required for the generation of the 48-kDa fragment but not for that of the 66-kDa fragment. These data suggest that there are two different integral forms of SecA in the membrane: SecASand SecAM. The combination of these two forms of SecA has several membrane-interacting domains. Both forms of SecA are integrated in the membrane, since both the 48- and 66-kDa fragments could be derived from urea- or Na2CO3-washed membranes. Moreover, all fragments are resistant to extraction with a high concentration of salt or with heparin, but the membrane-specific 48-kDa SecA domain is more sensitive to Na2CO3 or urea extraction. This suggests that this domain may interact with other membrane proteins in an aqueous microenvironment and therefore may form a part of the protein-conducting channel.
Where Schizophrenic Patients Commit Suicide: A Review of Suicide among Inpatients and Former Inpatients

Objective: To review the literature on suicide of inpatients with schizophrenia, to identify suicide risk factors as well as typical patterns of behavior and to suggest a rationale and strategies for future interventions. Method: A computerized MedLine, Excerpta Medica and PsycLit search supplemented by an examination of cross-references and reviews. Results: Up to half the suicides among patients with schizophrenia occur during inpatient admission. Inpatient suicides were found among those of a young age group who were predominantly single, childless and socially isolated. The vast majority experienced an illness characterized by long duration and prolonged psychiatric hospitalizations or multiple admissions and discharges. Up to 50% of the suicides occurred in the first few weeks and months following discharge from the hospital. The paranoid subtype of schizophrenia, where positive symptoms prevail and negative symptoms are few, is associated with a suicide risk that is three times greater than that associated with nonparanoid subtypes and eight times greater than the risk associated with the deficit subtype. Conclusions: Treatment of suicide is a major problem among inpatients with schizophrenia. Evidence suggests that suicide is generally carried-out by patients who have been recently discharged or by those who manage to get away from the hospital. Strategies aimed at preventing this phenomenon have been introduced to the medical personnel, but suicide in these patients does not seem to have been reduced. We emphasize the need to establish guidelines for the prevention of suicide in hospitalized patients with schizophrenia.
A model for operator endpoint stiffness prediction during physical human-robot interaction

Physical contact established during interaction between a human operator and a haptic device creates a coupled system with stability and performance characteristics different than its individual subsystems taken in isolation. Proper incorporation of operator dynamics in physical human-robot interaction (pHRI) conditions requires knowledge of system variables and parameters, some of which are not directly measurable. Operator endpoint impedance, for instance, cannot be directly measured in typical haptic control conditions. Several endpoint impedance estimation techniques have been explored in previous literature, based on measured kinematics and/or other correlated metrics. Arm muscle activity, measured through surface electromyography (sEMG), has been used in previous literature to estimate endpoint stiffness, which is the static component of impedance. Co-activation (co-contraction) of antagonistic arm muscles forming a pair around a joint is known to be the driving factor in modulation of endpoint stiffness. However, previous work employing muscle co-contraction to predict endpoint stiffness has mainly been absent, due in part to the inefficacy of operator models to incorporate muscle co-activation into the prediction scheme. The current study proposes a method for prediction of operator endpoint stiffness based on measured co-contraction levels of a select group of muscles. The proposed methodology incorporates an upper extremity musculoskeletal model that accounts for muscle redundancy and the role of muscle co-contraction on arm stiffness modulation. The study hypothesizes that a free parameter, currently known in the literature to represent the nullspace of the mapping between muscle forces and joint torques, is a random variable of which probability density function can be estimated. Changes in this parameter directly affect changes in operator endpoint stiffness. Ten healthy subjects were asked to resist perturbations induced by a one degree of freedom (DOF) haptic paddle device while measurements, including muscle activities of four arm muscles, were being carried out. Direct derivation of stiffness values at the endpoint was compared to simulated endpoint stiffness values obtained using the proposed predictive methodology. Ten out of forty prediction trials resulted in a statistically significant correlation between predicted and actual stiffness values. Impressive stiffness prediction results, with over 99% peak accuracy in value, were found in only one trial using a combination of the proposed method along with a standard static optimization method for muscle force computation. Though the possibility of using a probabilistic approach to stiffness prediction was shown, robustness and generalizability of the proposed approach to multi-DOF systems remain to be addressed.
Arteriographically Visualized Extravasation in Hypertensive Intracerebral Hemorrhage

Seven cases are reported in which extravasation of contrast medium from the lateral lenticulostriate artery was observed on cerebral angiography performed in the early stage of hypertensive intracerebral hemorrhage. We advance the theory that continuous bleeding from the ruptured artery with mechanical destruction and displacement of cerebral tissue is the cause of massive hematoma formation, and discuss the possibility of surgical treatment of the acute stage of hypertensive intracerebral hemorrhage.
The Effects of Mandatory Adoption of International Financial Reporting Standards on Information Environments

This study examines the information effects of mandatory adoption of International Financial Reporting Standards (IFRS) on listed firms in European countries. We find that both the analyst information environment (proxied by analyst forecast characteristics) and the public information environment (proxied by the information content of earnings announcements and the importance of earnings announcements relative to the total information environments of firms) improved for mandatory adopters after the IFRS regulation became effective in 2005. We also find similar information effects around 2005 for firms that voluntarily adopted IFRS before 2005. Additional analyses suggest that the improvement in the information content of earnings announcements in the post-IFRS period is primarily driven by earnings components excluded from analysts’ earnings forecasts. In addition, we find that adoption effects differ across countries and across legal origins.
From ideals to deals - the effect of arbitration experience on stakeholder behavior

In this paper, we study a two-party pie-sharing problem in the presence of asymmetries in the stakeholders' private endowments. Both the two stakeholders and third-party arbitrators may influence the outcome. We consider Nash-demand negotiations where the two stakeholders place demands and share the pie accordingly if demands are compatible, and elicit dictatorial allocations from the stakeholders and the arbitrators. The Nash demands by stakeholders are strategic; the dictatorial allocations by stakeholders and arbitrators are non-strategic. We are interested in the influence of the past arbitrator experience on stakeholder allocations and demands and the past negotiator experience on third-party arbitration allocations. We find that the ex-arbitrators' stakeholder allocations differ more from the impartial ideal than the stakeholder allocations by those without arbitration experience. In contrast with previous findings, the arbitration outcomes do not depend on the asymmetries in the previous negotiator roles. JEL Classification: C91, D74
Percutaneous Hallux Valgus Surgery Without Distal Metatarsal Articular Angle Correction

Background. Many factors are considered predictors of recurrence after hallux valgus (HV) surgery, including preoperative distal metatarsal articular angle (DMAA). The restoration of the bone and joint alignment would be more important than realigning the cartilaginous surface of the metatarsal head. Therefore, is DMAA correction essential for a good clinical and radiological results after HV surgery? This study aims to illustrate the results of percutaneous forefoot surgery (PFS) for correction of HV deformity without DMAA correction. Material and Methods. A prospective single-center study of 74 patients (89 feet), with mild-to-moderate hallux valgus deformity, who underwent PFS. The mean latest follow-up was 57.3 months. Results. Preoperative median visual analog scale was 7 points and AOFAS scores were 52 points. At the mean latest follow up both scores improved to 0 points and 90 points, respectively. Median HV angle and intermetatarsal angle changed from 30° and 12° preoperatively, to 21° and 11° at mean latest follow-up. Overall, 80% of the patients were satisfied or very satisfied. Recurrence of medial first metatarsal head pain occurred in 12 cases (13.5%). Conclusions. PFS, without DMAA correction, is a valid procedure for surgical correction in patients with HV, despite the slightly worse radiographic results in our study. Levels of Evidence: Level II: Prospective study
The Dynamic Research of Mobile and PC Online Media Visit Activities Effects on The E-Commerce Site Visit

In the e-commerce, the conversion into the multi-media is the important issue. According to the research by Nielsen Korea, the 83% of customers who purchase the products in the e-commerce utilize multi-channel to buy the products such as mobile and online [3]. Thus, to effectively implement online advertising, marketers should understand the customers’ path [15] in the multi-channel. The study of the multi-site activities plays an important role to predict customers’ purchase [28]. To explain the e-commerce site visit activities of customers, we have developed research model in terms of the online advertising. This research model is based on the study of Moe and Fader [23]. There are two types of composition in the research model. First, general site visit as an exploratory search have net effect on the shopping site visit because customers could acquire or develop information on the e-commerce site via online advertising. Secondly, the e-commerce site visit as a goal-directed search cause threshold of the e-commerce site visit because customers could achieve their goal. When the threshold is increased, the probability of a shopping site visit is decreased and vice versa. Thus, we have investigated the impact of customers’ previous visit activities (general site visit and shopping site visit) on the next e-commerce site visit in terms of dynamic view. Research data was provided by Cheil World Wide. This panel data include mobile and online log data of panelists from Jan. 2013 to March 2013. As the results, the customers’ e-commerce site visit on the online media would decrease the probability of e-commerce site visit because these visit activities increase the threshold of e-commerce site visit. This result is similar with the previous study [23]. Otherwise, since e-commerce site visit on the mobile media decrease the threshold, the customers’ probability of e-commerce site visit would increase In summary, the site visit activities on the mobile could improve the probability of e-commerce site visits.
People matter: commitment to employees, strategy and performance in Korean firms

The human element of enterprise is argued to be a vital resource for strategy execution. We show in a study of Korean businesses how an organization’s commitment to its employees’ well-being (OCE) can aid in the profitable execution of its positioning strategies. We found that OCE, by itself, sometimes has a weakly positive association with return on assets (ROA). But far more important, we found that ROA is strongly and positively influenced by the interaction between OCE and the dedicated pursuit of Porter’s (1980) strategies for achieving competitive advantage: these are cost leadership, marketing differentiation and innovative differentiation. In short, dedicated positioning strategies appear to be executed more effectively where organizations exhibit a high level of commitment to their employees; and conversely, OCE is apt to have a strong impact on ROA only in the context of a dedicated, that is intensive and thorough, positioning strategy. Copyright © 1999 John Wiley & Sons, Ltd.
On Seller Heterogeneity in the Housing Market

In the literature on bargaining and setting of reservation prices for housing, a number of variables important to the theory often do not appear in empirical work due to data limitations. We address this issue using National Association of Realtors data, which has a number of important characteristics such as urgency, race, number of children, and age. We find that seller attributes have an effect on list prices, list price reductions, transaction prices, and time on the market. In addition, constructs such as expected loss affect not only list priced, but other housing outcomes as well. JEL classification: R31
The influx of amino acids into the brain of the rat in vivo: the essential compared with some non-essential amino acids

The cerebral influx rates of fifteen amino acids were measured directly in living rats by means of a new technique which makes it possible to maintain a constant specific activity of a radioactively labelled amino acid in the bloodstream. A wide variation in the influx rates of the amino acids was found. These rates differed from those found by other workers using in vitropreparations, but are consistent with the theory that amino acids enter the brain mainly by carrier mediated transport processes with a high degree of specificity. There are a number of important differences between the behaviour of the transport processes in vivo and in vitro. The influx rates of the various amino acids were directly proportional to their concentrations in blood plasma (over the range of concentrations studied). All the nutritionally essential amino acids had relatively high influx rates as did other amino acids which the brain does not seem to be able to synthesize. On the other hand, amino acids that the brain can readily synthesize and two amino acids which are not normally found in mammalian tissues had low influx rates.
Evaluation of the traumatic brain injury early referral programme in Missouri

Purpose: Missouri's traumatic brain injury (TBI) early referral programme connects individuals with TBI to state services in the acute stages of recovery. This study evaluated the impact of this programme on service utilization and functional outcomes. Method: Sixty-seven individuals in the Early Referral (ER) programme were compared with 31 individuals who received services later in their recovery (controls) in terms of their functioning upon programme enrollment and programme services received. Telephone surveys were then completed with 29 ER and 22 later-referred controls assessing social/emotional and vocational functioning, as well as satisfaction with programme services. Results: The ER group had greater functional limitations than controls upon enrollment. Despite this, at follow-up the ER group evidenced significantly better social integration, emotional well-being and vocational functioning than the control group. Individuals in the ER group did not require/receive more programme resources to achieve these better outcomes. Across both groups, 91% reported feeling the programme is valuable for individuals with TBI. Conclusions: Missouri's TBI early referral programme provides efficacious and cost-effective targeted support for individuals with TBI. Contact with clients and their families during or shortly after acute rehabilitation appears to be associated with better functional outcomes without an increase in the level of services rendered.
A Self-Report Measure for the ICD-11 Dimensional Trait Model Proposal: The Personality Inventory for ICD-11

Proposed for the 11th edition of the World Health Organization’s International Classification of Diseases (ICD-11) is a dimensional trait model for the classification of personality disorder (Tyrer, Reed, & Crawford, 2015). The ICD-11 proposal consists of 5 broad domains: negative affective, detachment, dissocial, disinhibition, and anankastic (Mulder, Horwood, Tyrer, Carter, & Joyce, 2016). Several field trials have examined this proposal, yet none has included a direct measure of the trait model. The purpose of the current study was to develop and provide initial validation for the Personality Inventory for ICD-11 (PiCD), a self-report measure of this proposed 5-domain maladaptive trait model. Item selection and scale construction proceeded through 3 initial data collections assessing potential item performance. Two subsequent studies were conducted for scale validation. In Study 1, the PiCD was evaluated in a sample of 259 MTurk participants (who were or had been receiving mental health treatment) with respect to 2 measures of general personality structure: The Eysenck Personality Questionnaire—Revised and the 5-Dimensional Personality Test. In Study 2, the PiCD was evaluated in an additional sample of 285 participants with respect to 2 measures of maladaptive personality traits: The Personality Inventory for DSM-5 and the Computerized Adaptive Test for Personality Disorders. Study 3 provides an item-level exploratory structural equation model with the combined samples from Studies 1 and 2. The results are discussed with respect to the validity of the measure and the potential benefits for future research in having a direct, self-report measure of the ICD-11 trait proposal.
Evaluating User Activity in Enterprise Social Media

Organizations are deploying social media, such as blogs, to improve internal collaboration. Observing how users react to organizational work practices and company restructuring can help identify factors promoting effective use of social media within enterprises. This possibility is illustrated by two examples involving social media use at a large technology company, to identify how people attend to content and the robustness of communities formed through social media.
The neurobiology of deception: evidence from neuroimaging and loss-of-function studies

Purpose of reviewVisualization of how the brain generates a lie is now possible because of recent conceptual and technical advances in functional neuroimaging; this has led to a rapid increase in studies related to the cognitive neuroscience of deception. The present review summarizes recent work on the neural substrates that underlie human deceptive behavior. Recent findingsFunctional neuroimaging studies in healthy individuals have revealed that the prefrontal cortex plays a predominant role in deception. In addition, recent evidence obtained from loss-of-function studies with neuropsychological investigation and transcranial direct current stimulation has demonstrated the functional contribution of the prefrontal cortex to deception. Other research into the relationship between deception and the brain has focused on the potential use of functional MRI for lie detection, neural correlates of pathological lying, and brain mechanisms underlying inference of deceit by others. SummaryConverging evidence from multiple sources suggests that the prefrontal cortex organizes the processes of inhibiting true responses and making deceptive responses. The neural mechanisms underlying various other aspects of deception are also gradually being delineated, although the findings are diverse, and further study is needed. These studies represent an important step toward a neural explanation of complex human deceptive behavior.
Neomensularia duplicata gen. et sp. nov. (Hymenochaetales, Basidiomycota) and two new combinations

Neomensularia (Hymenochaetaceae) is a new genus introduced for N. duplicata sp. nov. (generic type), N. crocitincta and N. kanehirae combs. nov., based on a combination of distinct morphological characters and phylogenetic analyses inferred from nuc rDNA partial 28S and ITS datasets. The new genus is characterized by annual, pileate, brown to fuscous basidiocarps, duplex context, dimitic hyphal structure, ventricose, and hooked hymenial setae, golden yellow, thick-walled, smooth basidiospores that are negative in both Melzer’s reagent and Cotton Blue and a growth habit in tropical forests. Neomensularia duplicata closely resembles Mensularia radiata by hooked hymenial setae, but M. radiata has a homogenous context, larger pores (5–7 per mm), monomitic hyphal structure, hyphoid setae, larger cyanophilic basidiospores and occurs in temperate forests. Central American specimens labeled as Inonotus crocitinctus and Asian specimens identified as Fulvifomes kanehirae were re-examined. The duplex context, hooked hymenial setae and colored basidiospores are similar to N. duplicata. Phylogenetic inferences based on 28S and ITS sequence data confirm their affinities with N. duplicata and result in the proposal of new combinations, Neomensularia crocitincta and N. kanehirae.