Miracle-dz/UniFAR-FTUs huggingface dataset:
Total cost comparison of 2 biopsy methods for nonpalpable breast lesions.

OBJECTIVE To identify, quantify, and compare total facility costs for 2 breast biopsy methods: vacuum-assisted biopsy (VAB) and needle-wire-localized open surgical biopsy (OSB). STUDY DESIGN A time-and-motion study was done to identify unit resources used in both procedures. Costs were imputed from published literature to value resources. A comparison of the total (fixed and variable) costs of the 2 procedures was done. PATIENTS AND METHOD A convenience sample of 2 high-volume breast biopsy (both VAB and OSB) facilities was identified. A third facility (OSB only) and 8 other sites (VAB only) were used to capture variation. Staff interviews, patient medical records, and billing data were used to check observed data. One hundred and sixty-seven uncomplicated procedures (71 OSBs, 96 VABs) were observed. Available demographic and clinical data were analyzed to assess selection bias, and sensitivity analyses were done on the main assumptions. RESULTS The total facility costs of the VAB procedure were lower than the costs of the OSB procedure. The overall cost advantage for using VAB ranges from $314 to $843 per procedure depending on the facility type. Variable cost comparison indicated little difference between the 2 procedures. The largest fixed cost difference was $763. CONCLUSIONS Facilities must consider the cost of new technology, especially when the new technology is as effective as the present technology. The seemingly high cost of equipment might negatively influence a decision to adopt VAB, but when total facility costs were analyzed, the new technology was less costly.
Gum chewing combined with oral intake of a semi‐liquid diet in the postoperative care of patients after gynaecologic laparoscopic surgery

AIM AND OBJECTIVES To evaluate the effects of gum chewing combined with a semi-liquid diet on patients after gynaecologic laparoscopic surgery. BACKGROUND Previous studies suggested that chewing gum before traditional postoperative care promotes the postoperative recovery of bowel motility and function after open and laparoscopic surgery. However, gum chewing combined with a semi-liquid diet has not been reported in postoperative care of patients following gynaecologic laparoscopic surgery. DESIGN A prospective randomised study. METHODS Total 234 patients were randomly assigned after elective gynaecologic laparoscopic surgery to a gum chewing and semi-liquid diet group, a semi-liquid only diet group or a liquid diet group. The gum chewing and semi-liquid diet group chewed sugar-free gum with an oral intake of a semi-liquid diet six hours postoperatively. The semi-liquid only diet and liquid diet groups received a semi-liquid diet or a liquid diet, respectively. The time to first bowel sounds, time to first regular postoperative bowel sounds, time to first passage of flatus, time to first defecation, serum gastrin and incidences of hunger, nausea, vomiting and abdominal distension were recorded. Hunger and gastrointestinal sensations were assessed using a four-point scale. Serum gastrin was assayed pre- and postoperatively using a gastrin radioimmunoassay kit. RESULTS The gum chewing and semi-liquid diet group had first bowel sounds, first regular bowel sounds, first passage of flatus and first defecation earlier than the semi-liquid only and liquid groups. Increased serum gastrin was observed in the gum chewing and semi-liquid diet group. Incidences of nausea, vomiting and abdominal distention were not significantly different between these groups. CONCLUSION Chewing gum combined with an oral intake of a semi-liquid diet is safe and accelerates the postoperative recovery of bowel function. It might be recommended as a better postoperative care regimen for patients after gynaecologic laparoscopic surgery. RELEVANCE TO CLINICAL PRACTICE This study developed a new postoperative diet regimen to improve the postoperative care of patients undergoing laparoscopic gynecologic surgery.
Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons

To maintain homeostasis, hypothalamic neurons in the arcuate nucleus must dynamically sense and integrate a multitude of peripheral signals. Blood-borne molecules must therefore be able to circumvent the tightly sealed vasculature of the blood–brain barrier to rapidly access their target neurons. However, how information encoded by circulating appetite-modifying hormones is conveyed to central hypothalamic neurons remains largely unexplored. Using in vivo multiphoton microscopy together with fluorescently labeled ligands, we demonstrate that circulating ghrelin, a versatile regulator of energy expenditure and feeding behavior, rapidly binds neurons in the vicinity of fenestrated capillaries, and that the number of labeled cell bodies varies with feeding status. Thus, by virtue of its vascular connections, the hypothalamus is able to directly sense peripheral signals, modifying energy status accordingly.
Macrophage‐induced inflammation affects hippocampal plasticity and neuronal development in a murine model of HIV‐1 encephalitis

Cognitive, behavioral, and motor impairments, during progressive human immunodeficiency virus type 1 (HIV‐1) infection, are linked to activation of brain mononuclear phagocytes (MP; perivascular macrophages and microglia). Activated MPs effect a giant cell encephalitis and neuroinflammatory responses that are mirrored in severe combined immunodeficient (SCID) mice injected with human monocyte‐derived macrophages (MDM). Whether activated human MDMs positioned in the basal ganglia affect hippocampal neuronal plasticity, the brain subregion involved in learning and memory, is unknown. Thus, immunohistochemical techniques were used for detection of newborn neurons (polysialylated neuronal cell adhesion molecule [PSA‐NCAM]) and cell proliferation (Ki‐67) to assay MDM effects on neuronal development in mouse models of HIV‐1 encephalitis. Immunodeficient (C.B.‐17/SCID and nonobese diabetic/SCID, NOD/SCID) and immune competent (C.B.‐17) mice were injected with uninfected or HIV‐1‐infected MDM. Sham‐operated or unmanipulated mice served as controls. Neuronal plasticity was evaluated in the hippocampal dentate gyrus (DG) at days 7 and 28. By day 7, increased numbers of Ki‐67+ cells, PSA‐NCAM+ cells and dendrites in DG were observed in sham‐operated animals. In contrast, significant reductions in neuronal precursors and altered neuronal morphology paralleled increased microglial activation in both HIV‐1‐infected and uninfected MDM‐injected animals. DG cellular composition was restored at day 28. We posit that activated MDM induce inflammation and diminish DG neuronal plasticity. These data provide novel explanations for the cognitive impairments manifested during advanced HIV‐1 infection. © 2005 Wiley‐Liss, Inc.
Scalar Timing in Memory

A recent report of ours’ proposed an information-processing account of temporal generalization. The account posited a clock process, which was the basic time measurement device, and working and reference memory for storing the output of the clock either temporarily or relatively permanently. Records of time intervals in working and reference memory were then compared using a binary decision process, which dictated responding or not responding. The analysis concentrated on a relativistic Weber’s law property of the data from temporal generalization, and the constraints this property imposed on sources of variance in the information-processing stages. Our purpose here is to summarize that work and generalize the model in two ways: First we consider several sources of variance operating simultaneously. The original analysis demonstrated that if only one source of variance is present, it must be a scalar source, that is, it must result in a variable memory for which variance increases with the square of the mean. ’ In the generalized account proposed here, we will develop the conclusion that scalar sources dominate in some time ranges, while other sources may dominate in others. These ideas are then applied to two additional timing tasks with different characteristics.
How Does the Continental Crust Get Really Hot

There is widespread evidence that ultrahigh temperatures of 900–1000 °C have been generated in the Earth's crust repeatedly in time and space. These temperatures were associated with thickened crust in collisional mountain belts and the production of large volumes of magma. Numerical modelling indicates that a long-lived mountain plateau with high internal concentrations of heat-producing elements and low erosion rates is the most likely setting for such extreme conditions. Preferential thickening of already-hot back-arc basins and mechanical heating by deformation in ductile shear zones might also contribute to elevated temperatures.
Modulation of GH4 Cell Cycle via A1 Adenosine Receptors

Abstract: Identification and characterization of A1 adenosine receptors (A1Rs) in a tumor cell line derived from rat pituitary (GH4 cells) was performed by ligand binding and immunocytochemistry. Subsequently, the involvement of A1Rs in the regulation of cell proliferation was studied in these cells. The agonist N6‐(R)‐phenylisopropyladenosine (R‐PIA) did not modify the number of cultured cells, but it regulated the kinetics of the cell cycle. By means of experiments of pulse and of pulse and chase with bromodeoxyuridine and further labeling with Hoechst 33258, propidium iodide, and/or fluorescein‐conjugated antibodies against bromodeoxyuridine, it was demonstrated that R‐PIA, via A1Rs, accelerated progression from G0/G1 to S phase and from S to G2/M phase of the cell cycle, whereas the initiation of a new cycle occurred at the same time in treated and untreated cells. As a consequence, R‐PIA did not change the total length of the cycle. This is the first description of cell cycle regulation without modification of cell proliferation. Although pertussis toxin blocked the R‐PIA‐induced inhibition of cyclic AMP production in these cells, it did not affect the R‐PIA action on the cell cycle. In contrast, cholera toxin mimicked the action of R‐PIA. Thus, it is likely that regulation of the cell cycle via A1Rs is mediated by heterotrimeric G proteins different from those that mediate inhibition of adenylate cyclase. Due to the fact that cells in G0/G1 phase were less susceptible to secretory signals, adenosine, in an autocrine manner and by regulating the cell cycle kinetics, may contribute to the modulation of the secretory capacity of pituitary cells.
Hemorrhagic cystitis after allogeneic hematopoietic stem cell transplants is the complex result of BK virus infection, preparative regimen intensity and donor type

Background Hemorrhagic cystitis is a common cause of morbidity after allogeneic stem cell transplantation, frequently associated with BK virus infection. We hypothesized that patients with positive BK viruria before unrelated or mismatched related donor allogeneic hematopoietic stem cell transplantation have a higher incidence of hemorrhagic cystitis. Design and Methods To test this hypothesis, we prospectively studied 209 patients (median age 49 years, range 19–71) with hematologic malignancies who received bone marrow (n=78), peripheral blood (n=108) or umbilical cord blood (n=23) allogeneic hematopoietic stem cell transplantation after myeloablative (n=110) or reduced intensity conditioning (n=99). Donors were unrelated (n=201) or haploidentical related (n=8). Results Twenty-five patients developed hemorrhagic cystitis. Pre-transplant BK viruria detected by quantitative PCR was positive in 96 patients. The one-year cumulative incidence of hemorrhagic cystitis was 16% in the PCR-positive group versus 9% in the PCR-negative group (P=0.1). The use of umbilical cord blood or a haploidentical donor was the only significant predictor of the incidence of hemorrhagic cystitis on univariate analysis. There was also a trend for a higher incidence after myeloablative conditioning. Multivariate analysis showed that patients who had a positive PCR pre-transplant and received haploidentical or cord blood grafts with myeloablative conditioning had a significantly higher risk of developing hemorrhagic cystitis (58%) than all other recipients (7%, P<0.001). Conclusions Hemorrhagic cystitis is the result of a complex interaction of donor type, preparative regimen intensity, and BK viruria.
Negative thermal expansion in crystals with the zincblende structure: an EXAFS study of CdTe

The extended x-ray absorption fine structure (EXAFS) has been measured at both the K edges of cadmium and tellurium in CdTe, from liquid helium to room temperature, in order to investigate the local thermodynamic behaviour. The temperature dependences of the structural parameters obtained from the separate analysis of the two edges are perfectly consistent. The positive contribution to the thermal expansion due to the bond stretching and the negative contribution due to the tension effects are disentangled and quantified in terms of the bond thermal expansion and the perpendicular mean square relative displacement. The comparison with previous EXAFS results for Ge and CuCl shows that relevant correlations can be established between a number of local parameters measured by means of EXAFS and the properties of the lattice negative thermal expansion of tetrahedrally bonded semiconductors. The effective force constants derived from the EXAFS are compared with the force constants of a valence force field model.
Big Data and Marketing Analytics in Gaming: Combining Empirical Models and Field Experimentation

Efforts on developing, implementing, and evaluating a marketing analytics framework at a real-world company are described. The framework uses individual-level transaction data to fit empirical models of consumer response to marketing efforts and uses these estimates to optimize segmentation and targeting. The models feature themes emphasized in the academic marketing science literature, including incorporation of consumer heterogeneity and state dependence into choice, and controls for the endogeneity of the firm’s historical targeting rule in estimation. To control for the endogeneity, we present an approach that involves conducting estimation separately across fixed partitions of the score variable that targeting is based on, which may be useful in other behavioral targeting settings. The models are customized to facilitate casino operations and are implemented at the MGM Resorts International’s group of companies. The framework is evaluated using a randomized trial implemented at MGM involving about 1.
Endovascular treatment of basilar artery trunk aneurysms with Guglielmi detachable coils: clinical experience with 41 aneurysms in 39 patients.

OBJECT The authors present a retrospective analysis of their clinical experience in the endovascular treatment of basilar artery (BA) trunk aneurysms with Guglielmi detachable coils (GDCs). METHODS Between April 1990 and June 1999,41 BA trunk aneurysms were treated in 39 patients by inserting GDCs. Twenty-seven patients presented with subarachnoid hemorrhage, six had intracranial mass effect, and in six patients the aneurysms were found incidentally. Eighteen lesions were BA trunk aneurysms, 13 were BA-superior cerebellar artery aneurysms, four were BA-anterior inferior cerebellar artery aneurysms, and six were vertebrobasilar junction aneurysms. Thirty-five patients (89.7%) had excellent or good clinical outcomes; procedural morbidity and mortality rates were 2.6% each. Thirty-six aneurysms were selectively occluded while preserving the parent artery, and in five cases the parent artery was occluded along with the aneurysm. Immediate angiographic studies revealed complete or nearly complete occlusion in 35 aneurysms (85.4%). Follow-up angiograms were obtained in 29 patients with 31 aneurysms: the mean follow-up period was 17 months. No recanalization was observed in the eight completely occluded aneurysms. In 19 lesions with small neck remnants, seven (36.8%) had further thrombosis, three (15.8%) remained anatomically unchanged, and nine (47.3%) had recanalization caused by coil compaction. In one patient (2.6%) the aneurysm rebled 8 years after the initial embolization. CONCLUSIONS In this clinical series the authors show that the GDC placement procedure is valuable in the therapeutic management of BA trunk aneurysms. The endovascular catheterization of these lesions tends to be relatively simple, in contrast with more complex neurosurgical approaches. Endosaccular obliteration of these aneurysms also decreases the possibility of unwanted occlusion of perforating arteries to the brainstem.
Primary prevention of occupational asthma: identifying and controlling exposures to asthma-causing agents.

BACKGROUND Primary prevention of occupational asthma requires timely identification and regulation of asthma-causing agents. METHODS We examined 39 substances identified as causing allergic occupational asthma in the US to determine the basis for their identification and their regulatory status. We compared them with occupational asthmagens identified and regulated in the UK and Germany. RESULTS US regulatory agencies have not established consistent, evidence-based methods to identify and control exposures to substances that cause occupational asthma. Occupational asthmagens are identified primarily by non-regulatory US organizations, and most are not regulated to prevent asthma. CONCLUSIONS Implementing an evidence-based identification and regulatory process for occupational asthmagens will help to ensure primary prevention of occupational asthma in the US. This should include: establishing consistent identification criteria; publishing a list of occupational asthmagens; collecting use, exposure, and health effects information on asthma-causing substances; requiring medical surveillance and medical removal protection in addition to exposure limits; and stimulating development of safer alternatives.
Putting Employees in Their Place: The Impact of Hot Desking on Organizational and Team Identification

A study of employees in the finance industry tested the propositions (a) that work team identity is more salient than organizational identity when desks are assigned, whereas organizational identity is more salient when they are not; and (b) that this is partly because physical arrangements have a significant bearing on the way in which employees engage with the organization as well as who they are most likely to engage with (i.e., impacting on the type and focus of organizational participation). The study measured levels of work team and organizational identity in matched samples of employees (N=142) assigned to desks and not assigned (i.e., hot desked), as well as their perceptions of the use, importance, and effectiveness of electronic and face-to-face communication as indicators of different types of organizational participation. Results support the hypotheses. The perceived value of electronic communication also accounted for significant variance in organizational identification for all employees. Findings point to a number of practical implications relating to the use of hot desking in the workplace.
Therapeutic Effect of Human Umbilical Cord Multipotent Mesenchymal Stromal Cells in a Rat Model of Stroke

Background. Human umbilical cord multipotent mesenchymal stromal cells (UC-MSC) have recently been identified as ideal candidate stem cells for cell-based therapy. The present study was designed to evaluate therapeutic potentials of intracerebral administration of UC-MSC in a rat model of stroke. Methods. Rats were subjected to 2-hr middle cerebral artery occlusion and received 2×105 UC-MSC or phosphate-buffered saline as a control. Neurologic function evaluation was conducted weekly after transplantation. Brain injury volume and in vivo differentiation of transplanted UC-MSC were detected 2 or 5 weeks after the UC-MSC treatment. In addition, vascular density, vascular endothelial growth factor, and basic fibroblast growth factor expression in ipsilateral hemisphere after treatment and in vitro angiogenic potential of UC-MSC were assessed. Results. The transplanted UC-MSC survived for at least 5 weeks in rat brain. Compared with the phosphate-buffered saline control, the UC-MSC treatment significantly reduced injury volume and neurologic functional deficits of rats after stroke. In ischemic brain, UC-MSC widely incorporated into cerebral vasculature and a subset of them was capable of differentiating into endothelial cells. Furthermore, the UC-MSC treatment substantially increased vascular density and vascular endothelial growth factor and basic fibroblast growth factor expression in ipsilateral hemisphere of stroke. In vitro induction and tube formation assay further confirmed their angiogenic properties. Conclusions. UC-MSC transplantation could accelerate neurologic functional recovery of rats after stroke, which may be mediated by their ability to promote angiogenesis.
Motion and contrast enhancement separation model reconstruction from partial measurements in dynamic MRI

We propose a motion and contrast enhancement separation model in dynamic magnetic resonance imaging (MRI). Furthermore, the reconstruction is done from partial measurements to achieve faster dynamic MR imaging. The algorithm minimizes a linear combination of three terms, a data fitting functional and two regularization functionals corresponding to the nuclear and l1 norm. The proposed method is tested on simulated and real dynamic datasets. This paper suggests an image reconstruction model that directly induces clinically-relevant informations from partial measurements.
Prevalence of Metabolic Syndrome and its Related Risk Factors in the City of Oran, Algeria: the ISOR Study.

BACKGROUND Aging and lifestyle changes had led to an epidemiological transition, with a significant impact on the incidence of cardiovascular diseases in North Africa. OBJECTIVE The aim of this study was to determine the prevalence of metabolic syndrome and its associated factors, which were unknown, among an urban population in Algeria. METHODS During 2007-2009, 787 individuals aged 30-64 years, randomly selected from the list of insured persons residing in the city of Oran, participated in a clinical, anthropometric and biological survey. Participants were classified according to the National Cholesterol Education Program - Adult Treatment Panel (NCEP-ATP) III definition of metabolic syndrome. RESULTS The prevalence of metabolic syndrome was 20%, higher in women than men (25.9 vs 13.7%; P<.0001). Among the components of the syndrome, the most common risk factors observed in women were a low high-density lipoprotein (HDL) cholesterol concentration (60.4% vs 44.2% in men) and abdominal obesity (46.8% vs 30.1% in men) whereas men displayed more high blood pressure (42.5% vs 34.8% in women). In men, metabolic syndrome was more frequent in married and highly educated participants. In contrast, women with a high level of education and who had an intermediate level of physical activity seemed to be protected. CONCLUSIONS Metabolic syndrome, prevalent in the urban population of North Algeria, is associated with a high proportion of low HDL-cholesterol and abdominal obesity, especially among women. There is a need for prevention strategies involving promotion of physical activity for the whole population and screening for hypertension among men.