Miracle-dz/UniFAR-FTUs huggingface dataset:
Correlation between bone marrow karyotype and the occurrence of erythroblast micronuclei and nuclear budding in patients with myelodysplastic syndromes

147 patients with myelodysplastic syndromes were investigated for the presence of micronuclei and nuclear budding in bone marrow erythroblasts. The patients were divided into subgroups on the basis of bone marrow karyotype. 31 healthy bone marrow donors constituted a control group. Patients with monosomy 7 or 7q‐ and patients with major karyotypic abnormalities (MAKA) had significantly more erythroblasts with micronuclei and nuclear budding than the control group. Patients with a 5q‐ chromosome as the sole karyotypic aberration had more micronuclei than the controls. For other patients with MDS the differences were statistically nonsignificant.
Model for detection of membrane‐associated antigens on epithelial cells (HLA‐A, ‐B, ‐C alloantigens and pemphigus antigens)

Incubation of skin explant culture with HLA‐A, ‐B and ‐C alloantibodies results in detachment of cells at the periphery of the outgrowth. This detachment can be observed within I 1/2 h, using the reflection contrast microscope. During the detachment of the epithelial cell, characteristic changes occur, such as disorganization of the filopodia and lifting up of the cell borders from the surface of the Petri dish. The same changes were seen using antibodies against pemphigus antigens.
Effect of exercise intensity on oxygen consumption kinetics in non‐exercising muscle during exercise

This study examined the effect of exercise intensity on the kinetics of muscle oxygen consumption in non‐exercising forearm flexor muscles () during exercise. Seven healthy male subjects performed cycling exercise for 60 min at 30% of maximal oxygen consumption (%) and 30 min at 50% on separate days. The values at rest and during exercise were measured by near‐infrared spectroscopy. The at 30% significantly increased to 1·2 ± 0·1‐fold over resting value at 20 min after the beginning of exercise (P<0·05) and remained constant within 1·2‐ to 1·3‐fold over resting value until 60 min during exercise. The at 50% significantly increased to 1·2 ± 0·1‐fold over resting value at 15 min after the beginning of exercise (P<0·05). Subsequently, the at 50% increased with time to 1·3 ± 0·1‐fold over resting value at 20 min after the beginning of exercise and to 1·5 ± 0·2‐fold over resting value at 30 min. The 15–30 min of exercise at 50% was significantly higher than that at 30% (P<0·05). These data suggest that the increase in has a time lag from the beginning of exercise, and the kinetics of during exercise differs with exercise intensity. Therefore, we conclude that the kinetics of during exercise is dependent on exercise intensity.
Improving a Multiple Pitch Estimation Method With AR Models

Multiple pitch estimation (MPE) methods aim to detect the pitches of the sounds that are part of a certain mixture. A possible approach to such problem is applying a FIR filter bank in the frequency domain and choosing the filter that presents more energy. This process is equivalent to performing a set of pondered sums of the frequency domain components of a signal. When spectral lobes corresponding to existing partials merge, such process may fail. In this paper, AR models were used to provide an spectral representation where lobes tend to merge less. The proper choice of model significantly improved the MPE method.
Role of exogenous melatonin in reducing the cardiotoxic effect of daunorubicin and doxorubicin in the rat.

The aim of the studies was to examine the cardioprotective effect of melatonin during the anthracycline administration (daunorubicin, doxorubicin) in rats. Application of these drugs in chemotherapy is limited because of their cardiotoxicity. Rats of Buffalo strain were divided into groups according to the cytostatic drug used, its dose and sequence of administration (single intravenous [i.v.] dose of 10 mg/kg b.w., i.e., acute intoxication; 3 mg/kg b.w. weekly for 3 weeks, subchronic intoxication). Melatonin was administered subcutaneously before and after every injection of a cytostatic drug at a dose of 10 mg/kg b.w. The degree of cardiac muscle cell alterations was examined either histologically (Mean Total Score technique and the Billingham scale), or biochemically (levels of lipid peroxidation markers, malonyldialdehyde, and 4-hydroxyalkenals). Statistically significant decrease in cardiac muscle cell damage was noted with an aid of the Billingham scale after melatonin administration in acutely intoxicated doxorubicin-treated rats (p < 0.001). The similar phenomenon was observed using the Mean Total Score technique in case of acute daunorubicin or doxorubicin (p < 0.01 and p < 0.001, respectively) intoxications. A significant reduction in cardiac muscle cell lesions was detected either by the Billingham scale or by the Mean Total Score technique during subchronic intoxication with either of the anthracyclines when melatonin was given. Biochemical assays revealed significant decreases in malonyldialdehyde and 4-hydroxyalkenals levels following application of melatonin during either acute doxorubicin (p < 0.05) or subchronic daunorubicin (p < 0.01) intoxication. In summary, melatonin was found to exert a protective effect on the cardiac muscle cells, which was particularly evident after acute doxorubicin or subchronic daunorubicin intoxication, using either histological or biochemical methods.
Quality of life and needs of hospitalized schizophrenic patients in the Czech Republic.

OBJECTIVES The main aim of the study was to investigate the quality of life and the medicinal and social needs of patients hospitalized with schizophrenia in the Czech Republic to uncover potential issues in these areas. METHODS Relevant self-evaluating questionnaires (SQUALA for quality of life; CANSAS for medicinal and social needs) were used in a cohort of hospitalized schizophrenic patients undergoing rehabilitation before discharge from the mental hospital. RESULTS Two hundred and forty-four patients (women N=115) aged 18-58 years were involved in the study. The quality of life of hospitalized patients with schizophrenia was subjectively assessed as universally worse in comparison with the general Czech population (p<0.05 in most cases; two-sample Student's t-test), but patients were not wholly critical of their own health status and overestimated its quality (arithmetic mean 63.79 in the patients vs the range of 45.5-59.8 as the norm in the general Czech population). Intimate relations, financial matters, treatment of psychotic symptoms, and sexual life were among the most pressing medicinal and social needs in our study subjects. CONCLUSION The results of our study should stimulate psychiatric nurses in their effort not only to detect but also address the problems of schizophrenic patients concerning quality of life and unfulfilled needs. This can be done via education, guidance towards a healthy lifestyle, or providing patients with adequate exercise. Overall this issue is of significant importance in the Czech Republic due to the fact that legislative reform of mental health care emphasizing community care and psychiatric nursing has just been implemented.
Dynamic behaviour of under-deck cable-stayed bridges under the action of moving loads

Fernando Madrazo-Aguirre, born 1984, received his Civil Engineering degree from the University of Cantabria, Spain. He worked as a Chartered Structural Engineer for Saitec Engineering before joining Imperial College London as a PhD student. Dr Ruiz-Teran received her MEng and PhD from the University of Cantabria, Spain. She worked as Chartered Bridge Engineer for APIA XXI and Arenas & Asociados for several years before becoming an academic. She is currently a Lecturer at Imperial College London. Dr M Ahmer Wadee received his BEng and MSc from Imperial College London, and his PhD from the University of Bath. He has been lecturing at Imperial since 1999, and currently holds the position of Reader in Nonlinear Mechanics. He is a Fellow of the UK Institute of Mathematics and its Applications.
A test for publication bias in meta‐analysis with sparse binary data

A new test for the detection of publication bias in meta‐analysis with sparse binary data is proposed. The test statistic is based on observed and expected cell frequencies, and the variance of the observed cell frequencies. These quantities are utilized in a rank correlation test. Type I error rate and power of the test are evaluated in simulations; results are compared to those of two other commonly used test procedures. Sample sizes were generated according to findings in a survey of eight German medical journals. Simulation results indicate that, in contrast to existing test procedures, the new test holds the prescribed significance level when data are sparse. However, the power of all tests is low in many situations of practical importance. Copyright © 2006 John Wiley & Sons, Ltd.
Characteristic expansion of CD45RA+ CD27− CD28− CCR7− lymphocytes with stable natural killer (NK) receptor expression in NK‐ and T‐cell type lymphoproliferative disease of granular lymphocytes

We analysed the cell surface expression of chemokine receptors and natural killer receptors (NKRs) in addition to conventional T‐ and natural killer (NK)‐cell markers in patients with lymphoproliferative disease of granular lymphocytes (LDGL), and compared results between NK‐ and T‐LDGL subgroups. The subjects of this study were 15 LDGL patients: four NK‐LDGL and 11 T‐LDGL [six CD8+ T‐cell receptor (TCR) αβ+, four CD4+ TCRαβ+ and one CD8+ TCRγδ+] cases. Flow cytometric analysis showed that the expanding cells had a common phenotype, CD45RA+ CD27− CD28− CCR7−, in NK‐ and T‐LDGL patients irrespective of differences in TCR status. There were no marked differences in the expression patterns of chemokine receptors between NK‐ and T‐LDGL patients. Although restricted NKR subsets were expressed on both NK‐ and T‐large granular lymphocytes (LGLs), CD94 was the most widely expressed marker. These findings may be unique to cells of LDGL cases, because normal CD56dim NK cells frequently express killer cell immunoglobulin‐like receptors. Furthermore, analysis of NKR expression was repeated over an interval of more than 6 months, and fluctuations of NKR repertoire in the LGL clones were minimal.
Variables emocionales y sociomorales asociadas con el tipo de rol que asumen los alumnos y alumnas en el maltrato entre iguales

En este estudio se evaluan las emociones morales de culpa, pena y empatia, asi como la desconexion moral y laautoeficacia social con el proposito de determinar la relacion de tales variables con el tipo de rol que asumen los alumnosen el acoso escolar: 1) pro-bullying: iniciar, mantener y reforzar el maltrato, 2) defensor, intervenir a favor de la victimay, 3) espectador, mantenerse al margen del acoso escolar. El estudio se realizo en dos secundarias publicas de la Ciudadde Mexico, con 450 alumnos de 2o grado (48% chicos) de 12 a 14 anos. Se identificaron, a traves del procedimiento denominacion de pares, a 109 alumnos en el rol de pro-bullying, 70 espectadores y 46 defensores. Los alumnos clasificadosen el rol de pro-bullying obtuvieron puntajes bajos en culpa, pena y empatia, asi como un puntaje alto en desconexionmoral, en comparacion con los defensores y espectadores. Los defensores obtuvieron un mayor puntaje en empatia yautoeficacia social que los espectadores. Los varones desempenaron un papel mas activo en el maltrato entre iguales alser nominados con mayor frecuencia en el rol de pro-bullying, mientras que las chicas fueron nominadas como tipicamentecomo espectadoras y defensoras.
Influence of orthodontic treatment on development of third molars.

We aimed to find out whether extraction of lower premolars and subsequent closure of the space by a fixed appliance influenced the chances of mandibular third molars erupting. We compared angular and linear measurements of lower third molars on dental panoramic tomograms in 30 orthodontic patients with similar measurements from 30 patients with impacted third molars in intact arches. We found that the mesial angulation of lower third molars was reduced from 50 degrees to 43 degrees by orthodontic treatment (P< 0.001). Distance to the occlusal plane was reduced from 12 mm to 10 mm (P< 0.001). The space available increased from 4 mm to 11 mm (P< 0.001). We conclude that extraction of lower premolars and orthodontic treatment to achieve complete closure of the space allowed the positions of many impacted lower third molars to improve significantly.
Cirrhosis is not a contraindication to laparoscopic cholecystectomy: results and practical recommendations.

BACKGROUND Gallstones appear more frequently in patients with cirrhosis and open cholecystectomy in this patient population is associated with higher morbidity and mortality. The aim of the present study was to evaluate experience with laparoscopic cholecystectomy in patients with cirrhosis and to provide recommendations for management. METHODS Retrospective review of laparoscopic cholecystectomy in patients with cirrhosis from March 1999 to May 2008 was performed. Peri-operative characteristics and subgroup analysis were performed in patients with Child-Pugh's classes A, B and C cirrhosis. RESULTS A total of 68 patients were reviewed in this study. In all, 69% of the patients were Child's class A. The most common indication for cholecystectomy was chronic/symptomatic cholelithiasis (68%). Compared with patients with Child's class B and C, laparoscopic cholecystectomy in patients with Child's class A was associated with significantly decreased operative time (P= 0.01), blood loss (P= 0.001), conversion to open cholecystectomy (P= 0.001) and length of hospital stay (P= 0.001). CONCLUSIONS Laparoscopic cholecystectomy in patients with cirrhosis is feasible with no mortality and low morbidity, especially in patients with Child's class A cirrhosis.
Thalamic metabolism and corticospinal tract integrity determine motor recovery in stroke

We studied the role of remote metabolic depressions and pyramidal tract involvement regarding motor recovery following a first hemiparetic ischemic stroke. In 23 patients the regional cerebral glucose metabolism (rCMRGlu) was measured with positron emission tomography and the location and spatial extent of the stroke lesions were assessed by magnetic resonance imaging. Motor impairment during the acute and chronic stages (4 weeks after stroke) was determined by a motor score and recordings of magnetic evoked motor potentials. Twelve patients recovered significantly, whereas 11 patients retained a disabling hemiparesis. In contrast to patients with good motor recovery, rCMRGlu was severely depressed in the thalamus on the lesion side in patients with poor motor recovery. This patient group also showed more severe damage to the pyramidal tract on magnetic resonance images and a more pronounced reduction of the magnetic evoked motor potential amplitude. Neither the size of the stroke lesions nor the spatial extent of the lesional and remote rCMRGlu depressions outside the thalamus correlated with the thalamic hypometabolism and the improvement of the motor score. We conclude that preservation both of parts of the pyramidal tract and of the thalamic circuitry is a major determinant for the quality of hand motor recovery following acute brain ischemia in the adult.
Pacific Asia Conference on Information Systems ( PACIS ) July 2009 FACTORS AFFECTING COSUMERS ’ ATTITUDE TOWARDS ONLINE RESERVATION : AN EMPIRICAL ANALYSIS

With the rapid penetration of Internet in India and the increasing usage of the Internet for commercial purposes makes it imperative to understand and identify the factors which affects the attitude of consumers towards the adoption of Internet as an alternate channel for online reservations in case of Indian online travel industry. In this study we have identified perceived usefulness and playfulness as the significant predictors of consumers’ attitude towards using the Internet as an alternate channel for online reservation. We also found that novelty seeking and anxiety are not the significant predictors of attitude. These findings have implications for the online travel agents primarily because research has shown that a positive attitude leads to behavioural intention and hence behavioural action i.e. purchases (online transactions).
Proceedings of the Eighth International Conference on Conceptions of Library and Information Science, Copenhagen, Denmark, 19-22 August, 2013 The conceptual landscape of iSchools: examining current research interests of faculty members

Introduction. This study describes the intellectual landscape of iSchools and examines how the various iSchools map on to these research areas. Method. The primary focus of the data collection process was on faculty members’ current research interests as described by the individuals themselves. A co-word analysis of all iSchool faculty members’ research interests was used as a research method. The relations between the current research profiles of the iSchools were compared by calculating the cosine similarity between co-word profiles and visualized in network graphs. Results. The results show that the iSchools still contain many dominant themes from library and information science, but have an expanded conceptual landscape with the introduction of new iSchools. The methods used for data collection guaranteed the most current data available (in contrast to using publications) and the methods used for analyses gave multiple perspectives to the research landscape of the iSchools. Conclusions. The results of the present study showed how the current research landscape of the iSchools and the shared research interests were built by many topics that still reflect dominant information science topics (e.g., bibliometrics, information retrieval, and information seeking behaviour), but that there are also growing areas that reflect the iSchools’ interdisciplinary composition, thus answering the research questions. Page 1 of 13
Fragmentation affects plant community composition over time

&NA; Habitat fragmentation can lead to major changes in community composition, but little is known about the dynamics of these changes, or how community trajectories are affected by the initial state of habitat maturity. We use four landscape‐scale experiments from different biogeographic regions to understand how plant community composition responds to fragmentation over decades. Within each experiment, we consider first whether plant communities in the most‐fragmented treatments diverge in composition from plant communities in the least‐fragmented treatments. Second, because communities embedded in different fragments may become more similar to one another over time (biotic homogenization), we asked whether beta diversity – compositional variation across space – declines among fragments over time. Third, we assessed whether fragmentation alters the degree to which temporal change in fragmented landscapes is due to ordered species losses and gains (nestedness) versus species replacements (turnover). For each of these three questions, we contrasted patterns of compositional change in mature communities following fragmentation (disassembly; n = 2 experiments) with patterns in newly‐developing plant communities in fragments cleared of vegetation (assembly; n = 2 experiments). In the two studies where communities were disassembling, community composition in the most‐fragmented habitats diverged from that in least‐fragmented habitats. Beta diversity within a fragmentation treatment did not change over time at any of the four sites. In all four experiments, temporal patterns of compositional change were due mostly to species turnover, although nestedness played a role in the least‐fragmented sites in two of the studies. Overall, the impacts on community composition varied among landscape experiments, and divergence may have been affected by the maturity of the plant community. Future comparisons across ecosystems that account for species identities (vs simply richness) will be critical for predicting the effects of fragmentation, managing mature plant communities in remnants, and restoring plant communities where habitat has been lost.
Positive Dependence Properties of Conditionally Independent Random Lifetimes

Conditions under which conditionally independent random variables are positive dependent are described in this paper. For example, it is shown that if the conditionally independent random variables increase in the hazard rate sense in the condition, th en they are WBF (weakened by failures). It is also shown that if the conditionally independent random variables increase in the likelihood ratio sense in the condition, then they are MTP2 (multivariate totally positive of order 2). The results are given for the cases in which the condition is either a random variable or a random vector. Some applications in the areas of imperfect repair, budget allocation, random environments, and discrete-time filtering, illustrate the theory.
Survival of Host-Associated Bacteroidales Cells and Their Relationship with Enterococcus spp., Campylobacter jejuni, Salmonella enterica Serovar Typhimurium, and Adenovirus in Freshwater Microcosms as Measured by Propidium Monoazide-Quantitative PCR

ABSTRACT The ideal host-associated genetic fecal marker would be capable of predicting the presence of specific pathogens of concern. Flowthrough freshwater microcosms containing mixed feces and inocula of the pathogens Campylobacter jejuni, Salmonella enterica serovar Typhimurium, and adenovirus were placed at ambient temperature in the presence and absence of diurnal sunlight. The total Enterococcus DNA increased during the early periods (23 h) under sunlight exposure, even though cultivable Enterococcus and DNA in intact cells, as measured by propidium monoazide (PMA), decreased with first-order kinetics during the entire period. We found a significant difference in the decay of host-associated Bacteroidales cells between sunlight exposure and dark conditions (P value < 0.05), whereas the persistence of host-associated Bacteroidales DNA was comparable. The 2-log reduction times of adenovirus were 72 h for sunlight exposure and 99 h for dark conditions with similar decay rate constants (P value = 0.13). The persistences of fecal Bacteroidales cells and Campylobacter cells exposed to sunlight were similar, and host-associated Bacteroidales DNA and waterborne pathogen DNA were degraded at comparable rates (P values > 0.05). Overall, the ratio of quantitative PCR (qPCR) cycle threshold (CT ) values with and without PMA treatment was indicative of the time elapsed since inoculation of the microcosm with (i) fecal material from different animal sources based on host-associated Bacteroidales and (ii) pure cultures of bacterial pathogens. The use of both PMA-qPCR and qPCR may yield more realistic information about recent sources of fecal contamination and result in improved prediction of waterborne pathogens and assessment of health risk.