Miracle-dz/UniFAR-FTUs huggingface dataset:
The Impact of Facebook Use on Micro-Level Social Capital: A Synthesis

The relationship between Facebook use and micro-level social capital has received substantial scholarly attention over the past decade. This attention has resulted in a large body of empirical work that gives insight into the nature of Facebook as a social networking site and how it influences the social benefits that people gather from having social relationships. Although the extant research provides a solid basis for future research into this area, a number of issues remain underexplored. The aim of the current article is twofold. First, it seeks to synthesize what is already known about the relationship between Facebook use and micro-level social capital. Second, it seeks to advance future research by identifying and analyzing relevant theoretical, analytical and methodological issues. To address the first research aim, we first present an overview and analysis of current research findings on Facebook use and social capital, in which we focus on what we know about (1) the relationship between Facebook use in general and the different subtypes of social capital; (2) the relationships between different types of Facebook interactions and social capital; and (3) the impact of self-esteem on the relationship between Facebook use and social capital. Based on this analysis, we subsequently identify three theoretical issues, two analytical issues and four methodological issues in the extant body of research, and discuss the implications of these issues for Facebook and social capital researchers.
Debt financing and firm performance: an empirical study based on Swedish data

Purpose - – The purpose of this study is to examine the relationship between debt level and performance among small and medium-sized enterprises (SMEs). Design/methodology/approach - – Unlike the vast majority of previous research, this study uses three-stage least squares (3SLS) and fixed-effects models to analyse a comprehensive, cross-sectoral sample of 15,897 Swedish SMEs operating in five industry sectors during the 2009-2012 period. Findings - – This study confirms that debt ratios, in terms of trade credit, short-term debt and long-term debt, negatively affect firm performance in terms of profitability. As a high debt ratio seems to increase the agency costs and the risk of losing control of the firm, SME owners and managers tend to finance their businesses with equity capital to a fairly high degree. Practical implications - – As debt policy significantly influences firm performance, and thereby firm value and survival, SME owners and managers should focus on finding a satisfactory debt level. Originality/value - – To the authors’ best knowledge, this study is among the first to use 3SLS and fixed-effects models to analyse the relationship between debt level and firm performance. Moreover, while most previous research has examined listed firms, this study highlights the issue among SMEs, which play a fundamental role in the economy.
Cell proliferation and apoptosis in human middle ear cholesteatoma.

OBJECTIVE To compare the pattern of proliferation and apoptotic cell death in cholesteatoma tissues with that in normal skin. PARTICIPANTS The cholesteatoma tissue samples were excised from 10 patients during surgery. Normal skin specimens collected from the external ear canal of 6 of the 10 patients were used as controls. RESULTS In all cholesteatoma tissue samples, apoptotic cells were not seen in the basal cell layer, but they were observed in the suprabasal, prickle, and granular cell layers. In skin specimens obtained from normal external ear canal skin, in which the suprabasal cell layer was comparatively small, similar kinetics of apoptotic cell death were observed. Immunohistochemical analysis using a monoclonal antibody to proliferation cell nuclear antigen demonstrated the presence of proliferating cells in the basal and suprabasal cell layers of the normal external ear canal skin, whereas in the cholesteatoma tissue samples, large numbers of proliferation cell nuclear antigen-positive cells were also observed in the prickle and granular cell layers. CONCLUSIONS Proliferation in cholesteatoma epidermal cells is not uncontrolled, as it is in malignant tumors. Our results demonstrate an increase in the rate of proliferation and apoptotic cell death in cholesteatoma epidermis.
Host Gene Induction and Transcriptional Reprogramming in Kaposi’s Sarcoma-Associated Herpesvirus (KSHV/HHV-8)-Infected Endothelial, Fibroblast, and B Cells

Kaposi’s sarcoma-associated herpesvirus (KSHV/HHV-8) is etiologically linked to the endothelial tumor Kaposi’s sarcoma and with two lymphoproliferatve disorders, primary effusion lymphoma and multicentric Castleman’s disease. HHV-8 infects a variety of target cells both in vivo and in vitro, binds to the in vitro target cells via cell surface heparan sulfate, and uses the α3β1 integrin as one of the entry receptors. Within minutes of infection, HHV-8 induced the integrin-mediated signaling pathways and morphological changes in the target cells (S. M. Akula et al., Cell, 108: 407–419, 2002; P. P. Naranatt et al., J. Virol., 77: 1524–1539, 2003). As an initial step toward understanding the role of host genes in HHV-8 infection and pathogenesis, modulation of host cell gene expression immediately after infection was examined. To reflect HHV-8’s broad cellular tropism, mRNAs collected at 2 and 4 h after infection of primary human endothelial [human adult dermal microvascular endothelial cells (HMVECd)] and foreskin fibroblast [human foreskin fibroblast (HFF)] cells and human B cell line (BJAB) were analyzed by oligonucleotide array with ∼22,000 human transcripts. With a criteria of >2-fold gene induction as significant, ∼1.72% of the genes were differentially expressed, of which, 154 genes were shared by at least two cells and 33 genes shared by all three cells. HHV-8-induced transcriptional profiles in the endothelial and fibroblast cells were closely similar, with substantial differences in the B cells. In contrast to the antiapoptotic regulators induced in HMVECd and HFF cells, proapoptotic regulators were induced in the B cells. A robust increase in the expression of IFN-induced genes suggestive of innate immune response induction was observed in HMVECd and HFF cells, whereas there was a total lack of immunity related protein inductions in B cells. These striking cell type-specific behaviors suggest that HHV-8-induced host cell gene modulation events in B cells may be different compared with the adherent endothelial and fibroblast target cells. Functional clustering of modulated genes identified several host molecules hitherto unknown to HHV-8 infection. These results indicate that early during infection, HHV-8 reprograms the host transcriptional machinery regulating a variety of cellular processes including apoptosis, transcription, cell cycle regulation, signaling, inflammatory response, and angiogenesis, all of which may play important roles in the biology and pathogenesis of HHV-8.
THE SCHOOL AS A SETTING TO PROMOTE STUDENT HEALTH AND WELLBEING

The Health Promoting School (HPS) is s a model that advances both the health and learning needs of students. Yet there is a lack of consensus on student indicators that reflect a HPS or a coherent understanding of what a HPS represents amongst various stakeholders. The goal of this research was to establish indicators of student health and wellbeing associated with policies and practices in schools, and to further our understanding of health promoting schools. The research proceeded in three phases. The first phase established a relationship between student health and academic achievement. The second phase examined the associations amongst student health and wellbeing and student and schoollevel factors. The third phase involved case studies of two schools in Ontario to examine the organisational and structural elements associated with achieving a HPS, and the mechanisms by which these elements support student health and wellbeing. The association between students’ self-rated health and their academic achievement found in the first phase provides a platform for advancing the health promoting school agenda in Canada at the research and policy levels. Subsequent findings established an association between the environment and disciplinary climate in schools, and the school’s academic and socioeconomic standing to student health and wellbeing outcomes. These findings also suggest overlapping effects of schools and neighbourhoods on students’ health and wellbeing, implying that school health promoting efforts will be more successful when partnered with efforts within neighbourhoods and communities. Finally, the case studies suggest that embracing a HPS philosophy that addresses students’ emotional and physical wellbeing may help support students’ overall learning. Findings, presented in an implementation model of a HPS, emphasise key action areas that need to be addressed when implementing HPS initiatives and enhancing the capability of the education system to improve the health and learning of students.
Identification of anaplastic lymphoma kinase break points and oncogenic mutation profiles in acral/mucosal melanomas

Acral and mucosal melanomas, the two most common subtypes of melanoma in China, exhibit different genetic alterations and biologic behavior compared with other subtypes of melanomas. The purpose of this study was to identify the genetic alterations in patients with acral or mucosal melanomas in southern China. Fluorescence in situ hybridization (FISH), immunohistochemistry (IHC) analysis, polymerase chain reaction (PCR), and quantitative real‐time reverse transcriptase PCR (qRT‐PCR) were used to assess the anaplastic lymphoma kinase (ALK) break points. Furthermore, a mass spectrometry–based genotyping platform was used to analyze 30 acral melanomas and 28 mucosal melanomas to profile 238 known somatic mutations in 19 oncogenes. ALK break points were identified in four acral cases (6.9%). Eight (13.8%) cases harbored BRAF mutations, six (10.3%) had NRAS mutations, four (6.9%) had KIT mutations, two (3.5%) had EGFR mutations, two (3.5%) had KRAS mutations, two (3.5%) had MET mutations, one (1.7%) had an HRAS mutation, and one (1.7%) had a PIK3CA mutation. Two cases exhibited co‐occurring mutations, and one case with a BRAF mutation had a translocation in ALK. This study represents a comprehensive and concurrent analysis of the major recurrent oncogenic mutations involved in melanoma cases from southern China. These data have implications for both clinical trial designs and therapeutic strategies.
Third-Degree Price Discrimination with Buyer Power

Abstract This paper introduces a model of third-degree price discrimination where a seller's pricing power is constrained by buyers' outside options. Price uniformity performs more efficiently than discriminatory pricing, as uniform pricing allows weaker buyers to exploit the more attractive outside option of stronger buyers. This mechanism is markedly different from the mechanisms that are at work in case uniform pricing is imposed on an unconstrained monopolist.
Increasing incidence of both juvenile-onset Crohn's disease and ulcerative colitis in Scotland

Objective A previous study reported a three-fold rise in the incidence of juvenile-onset Crohn's disease in Scottish children and a marginal fall in ulcerative colitis between 1968 and 1983. The present study aimed to document the incidence of juvenile-onset inflammatory bowel disease between 1981 and 1995 and examine temporal trends between 1968 and 1995 in Scotland. Setting Scotland (latitude 55–60°N) has a total area of 77 837 km2 (30 405 square miles) and includes four urban centres each with a population of over 100 000. Participants The Scottish hospital discharges linked database was used to identify 1002 patients less than 19 years old who were coded as having inflammatory bowel disease between 1981 and 1997. All case notes were reviewed and diagnoses verified. Incident cases were defined as those with symptom onset before or at 16 years of age between 1 January 1981 and 31 December 1995. Results During the 15 year period 1981–1995, 438 incident cases of Crohn's disease and 227 of ulcerative colitis were identified, giving standardized incidences of 2.5 cases and 1.3 cases per 100 000 population per year for Crohn's disease and ulcerative colitis respectively. On 31 December 1995 there were 150 children ⩽ 16 years of age with Crohn's disease and 101 with ulcerative colitis, giving crude prevalences of 13.7 cases per 100 000 population for Crohn's disease and 9.2 for ulcerative colitis. The continuing rise in Crohn's disease incidence between 1981 and 1995 fits that predicted by linear trend analysis of the 1968–1983 data. The incidence of Crohn's disease in the 12–16 age range almost doubled between 1981 and 1995 and was greater for males than females. Ulcerative colitis incidence was thought to show a slight fall in the 1968–1983 data, but this is reversed in the 1981–1995 data. Conclusion The incidence of juvenile-onset Crohn's disease continues to rise in Scotland and the prevalence has increased by 30% since 1983. Unlike the previous report from Scotland, the incidence of juvenile-onset ulcerative colitis also is apparently rising. Whether this represents a real rise in incidence, or merely the inclusion of milder cases which were not previously hospitalized remains uncertain.
Perceived quality in organic and conventional pork markets in Germany

Abstract Food choice and consumption are based on perceived product quality, consumer attitudes, socio-demographics as well as economic factors. This article analyzes the impact of quality characteristics, attitudes, and socio-demographics on consumption of organic and conventional pork. Data come from a German consumer survey. A bivariate ordered probit model is used to test the role of quality perception in explaining choice over organic versus conventional pork. Clear differences in consumers’ use of certain quality characteristics emerge as consumers perceive and evaluate conventional and organic fresh pork. Product appearance, perceived food safety, and production method are especially important characteristics. An increased consumption of conventional pork decreases the likelihood of consuming organic pork and vice versa.
Learning mechanisms and differential performance in alliance portfolios

This study assesses the differential performance effects of learning mechanisms in alliance portfolios. Investigating two distinct types of learning mechanisms (i.e. integrating and institutionalizing mechanisms), the results show that different learning mechanisms have different performance effects at distinct levels of alliance experience.The results are based on a detailed survey among alliance managers and vice-presidents of 192 firms reporting on over 3400 alliances formed over the period 1997—2001.The main lesson from this study is that firms can deliberately develop their alliance capabilities by using integrating mechanisms to transfer prior experiences.
Opposing Wind Energy Landscapes: A Search for Common Cause

Although wind power is local, sustainable, affordable, and carbon free, mounting public opposition to the landscape changes it produces threatens its expansion. In an era when many countries are looking to renewable energy as an answer to questions about national security and the risks of climate change, it is important to explain the sources of this reaction. This article looks for similarities in public resistance to wind developments in four diverse settings: Palm Springs, California; Cape Cod, Massachusetts; the Isle of Lewis, Scotland; and Oaxaca State, Mexico. Despite the natural and cultural diversity among these places, there are five common threads in the opposition that has been experienced: immobility, the site specificity of the resource; immutability, an expectation of landscape permanence; solidarity, the close relationship between people and the land; imposition, a sense of marginalization; and place identity, a loss of security. Considering more deeply the relationship between land and life, in advance of the development of renewable energy resources, will help smooth the otherwise bumpy road toward a more sustainable future.
Natural Products from Marine Algae of the Genus Osmundaria (Rhodophyceae, Ceramiales)

The present work is a review of the natural products isolated from red marine algae of the genus Osmundaria (including Vidalia), which intends to encompass their occurrence in the species of this genus, the possible synonymies, their geographic distribution, their structural variety and their biological potential as prototypes for the pharmaceutical industry and as active principles of cosmetics. At the end, we provide a table with these natural products and their biological activities.
Social norms and emission tax multiple equilibria in adopting pollution abatement device

The effect of social norm is addressed in an adoption game, where an emission tax is used to motivate oligopolistic firms to adopt a pollution abatement device. We ask if the intrinsic motivation from social norm alone can motivate firms to participate in adoption. The multiple equilibria in the adoption game indicates two possibilities: this intrinsic motivation may or may not enhance adoption. The existing literature on equilibrium selection further suggests that the most likely outcome is that it cannot enhance adoption. Next, by keeping the assumption of symmetry, we show that if cooperation is an option for firms, then the presence of two coordination effects (social norm on adoption and cooperation benefits on output) will result in the existence of asymmetric adoptions.
Industry Characteristics and Financial Risk Contagion

This article proposes a new measure of tail risk spillover: the conditional coexceedance (CCX), defined as the number of joint occurrences of extreme negative returns in an industry, conditional on an extreme negative return in the financial sector. The empirical application provides evidence of significant volatility and tail risk spillovers from the financial sector to many real sectors in the U.S. economy from 2001 to 2011. These spillovers increase in crisis periods. The CCX in a given sector is positively related to its amount of debt financing and negatively related to its valuation and investment. Therefore, real economy sectors—which require relatively high debt financing and whose value and investment activity are relatively lower—are prime candidates for stock price volatility and depreciation in the wake of a financial sector crisis. Evidence also suggests that the higher the industry’s degree of competition, the stronger the tail risk spillover from the financial sector.
Comparison of reading and spelling in patients with probable Alzheimer's disease.

Patients with probable Alzheimer's disease (AD) are reported to show mild, but reliable, difficulties reading aloud and spelling to dictation exception words, which have unusual or unpredictable correspondence between their spelling and pronunciation (e.g., touch). To understand the cognitive dysfunction responsible for these impairments, 21 patients and 27 age-and education-matched controls completed specially designed tests of single-word oral reading and spelling to dictation. AD patients performed slightly below controls on all tasks and showed mildly exaggerated regularity effects (i.e., the difference in response accuracy between words with regular spellings minus exception words) in reading and spelling. Qualitative analyses, however, did not demonstrate response patterns consistent with impairment in central lexical orthographic processing. The authors conclude that the mild alexia and agraphia in AD reflect semantic deficits and nonlinguistic impairments rather than a specific disturbance in lexical orthographic processing.
A comparative analysis of funding schemes for public infrastructure spending in Quebec

The economic literature has been investigating the positive relation between public infrastructure spending and the productivity of the private sector since Munnell (1992). We have introduced this relationship into a recursive dynamic computable general equilibrium model of the Quebec economy to investigate various funding schemes to scale up infrastructure spending in the province. We draw our assumptions from Estache et al. (2010) combined with sectoral elasticity parameters. We conduct a comparative analysis where the funding comes from debt alone, and debt with sales tax, income tax and business tax. Our main finding is that the income tax seems to produce the most positive effects and the businesses tax the most negative effects, though differences are small.
Union Wage Effects in Australia: Evidence from Panel Data

Using data from the Household, Income and Labour Dynamics in Australia (HILDA) Survey, our research indicates that unobserved heterogeneity substantially biases cross-sectional estimates of union wage effects upward for both males and females. Estimates of the union wage premium for male workers between the ages of 25 and 64 fall from 8.7 percent to 5.2 percent after controlling for unobserved heterogeneity. For females aged 25 to 63 the estimated 4.0 percent cross-sectional union wage premium falls to 1.9 once unobserved heterogeneity is controlled for. Our results also indicate positive sorting by unobserved skills into union membership, especially among low skilled male and female workers. There is also evidence of negative sorting into unions among the most highly skilled.
To hedge or not to hedge: the use of epistemic modal expressions in popular science in English texts, English–German translations, and German original texts

Abstract Hedging plays a significant role in both scientific writing proper and its popularized form. However, most research has concentrated on the former text type, while comparatively little attention has been paid to the phenomenon in popular science. The present study uses a corpus of English popular scientific articles, their German translations, and original German popular scientific articles to investigate the use of epistemic modal markers (such as might, could, perhaps), which represent a common form of hedging, as they serve to mark the speaker's uncertainty about the truth of a proposition. The analysis shows noteworthy differences in usage between English and German. The English texts make use of epistemic modal markers much more frequently than the German original texts. Markers expressing mere possibility (e.g., maybe) are particularly more frequent in English, while German rather uses markers of high probability (e.g., probably). These differences can be related to divergent communicative preferences, specifically to a preference for indirectness and addressee-orientation in English texts, contrasting with a preference for directness and content-orientedness in German. The German translated texts are situated inbetween English and German originals, i.e., they exhibit some degree of adaptation to German textual conventions as well as some degree of “shining-through” of the English conventions.
A review of the behavioral risk research with special application to developing countries

Experimental economics, from its foundation, has grown out of a desire to produce more powerful tests of decision-making processes, as well as employ a more constructive methodology for generating new behavioral models. This has particularly been the case in the study of behavior under risk and uncertainty, where it can be extremely difficult to isolate behavioral responses to perceived risk from unanticipated changes in the underlying risk outside of the laboratory. The purpose of this paper is to provide on overview of the regularities in behavior of individuals facing decisions that involve risk or uncertainty. In this overview will pay particular attention to the potential applications for production and policy behavior in developing countries. Risk is widely acknowledged as a defining problem of agrarian behavior. This overview is intended to provide a deeper understanding of the costs and impacts resulting from risk.