Miracle-dz/UniFAR-FTUs huggingface dataset:
Value of the aVR lead in differential diagnosis of atrioventricular nodal reentrant tachycardia.

AIMS Despite the several electrocardiographic (ECG) criteria, misclassification may still occur in differential diagnosis of the regular paroxysmal supraventricular tachycardia (PSVT). The aim of the present study was to evaluate the diagnostic accuracy of the aVR lead in ECG differentiation of atrioventricular nodal reentrant tachycardia (AVNRT) and atrioventricular reciprocating tachycardia (AVRT). METHODS AND RESULTS A 12-lead ECG was recorded in 150 consecutive patients (96 women, mean age, 45 ± 13.5 years) with drug-refractory regular PSVT during both sinus rhythm and tachycardia. All ECGs were reviewed by two experienced electrophysiologists who had no knowledge of the tachycardia mechanism. The ECG recordings were evaluated for standard criteria as well as our newly proposed criterion of pseudo-r' in the lead aVR. Mechanism of arrhythmia was confirmed by the electrophysiological study and the successful catheter ablation. Patients with AVNRT were older (50 ± 10 vs. 37 ± 15 years, P = 0.001), predominantly female (71 vs. 53%, P = 0.03), and presented with slower tachycardia (175 ± 25 vs. 186 ± 26 b.p.m., P = 0.01). Among the ECG criteria of the AVRT diagnosis, visible P-wave with RP interval ≥ 100 ms had highest diagnostic accuracy (sensitivity 79%, specificity 87%, and positive predictive value 79%). For AVNRT diagnosis, pseudo-r' in aVR had a higher sensitivity, specificity, and predictive values compared with the conventional criteria of the pseudo-r' in V1 and pseudo-s in inferior leads (all P < 0.05). CONCLUSIONS New criterion of pseudo-r' in lead aVR appears to be more accurate than the standard ECG criteria for ECG diagnosis of AVNRT.
Dendritic architecture of hypoglossal motoneurons projecting to extrinsic tongue musculature in the rat

The tracer, cholera toxin‐horseradish peroxidase, was used to determine the dendritic architecture and organization of hypoglossal motoneurons in the rat. In 22 animals, the tracer was injected unilaterally into either the geniohyoid, genioglossus, hyoglossus, or styloglossus muscle. Within the hypoglossal nucleus, motoneurons innervating the extrinsic tongue muscles were functionally organized. Geniohyoid and genioglossus motoneurons were located within the ventrolateral and ventromedial subnuclei, respectively, while hyoglossus and styloglossus motoneurons were located within the dorsal subnucleus.
Basal root whorl number: a modulator of phosphorus acquisition in common bean (Phaseolus vulgaris).

BACKGROUND AND AIMS Root architectural phenes enhancing topsoil foraging are important for phosphorus acquisition. In this study, the utility of a novel phene is described, basal root whorl number (BRWN), that has significant effects on topsoil foraging in common bean (Phaseolus vulgaris). METHODS Whorls are defined as distinct tiers of basal roots that emerge in a tetrarch fashion along the base of the hypocotyl. Wild and domesticated bean taxa as well as two recombinant inbred line (RIL) populations were screened for BRWN and basal root number (BRN). A set of six RILs contrasting for BRWN was evaluated for performance under low phosphorus availability in the greenhouse and in the field. In the greenhouse, plants were grown in a sand-soil media with low or high phosphorus availability. In the field, plants were grown in an Oxisol in Mozambique under low and moderate phosphorus availability. KEY RESULTS Wild bean accessions tended to have a BRWN of one or two, whereas cultivated accessions had BRWN reaching four and sometimes five. BRWN and BRN did not vary with phosphorus availability, i.e. BRWN was not a plastic trait in these genotypes. Greater BRWN was beneficial for phosphorus acquisition in low phosphorus soil. Genotypes with three whorls had almost twice the shoot biomass, greater root length and greater leaf area than related genotypes with two whorls. In low phosphorus soil, shoot phosphorus content was strongly correlated with BRWN (R(2) = 0.64 in the greenhouse and R(2) = 0.88 in the field). Genotypes with three whorls had shallower root systems with a greater range of basal root growth angles (from 10 to 45 ° from horizontal) than genotypes with two whorls (angles ranged from 60 to 85 ° from horizontal). CONCLUSIONS The results indicate that BRWN is associated with increased phosphorus acquisition and that this trait may have value for selection of genotypes with better performance in low phosphorus soils.
Active vibration suppression R+D for the next linear collider

The nanometer scale beam sizes at the interaction point in linear colliders limit the allowable motion of the final focus magnets. We have constructed a prototype system to investigate the use of active vibration damping to control magnet motion. Inertial sensors are used to measure the position of a test mass, and a DSP based system provides feedback using electrostatic pushers. Simulation and experimental results for the control of a mechanically simple system are presented.
MODULATION OF ENDOTOXIN-INDUCED NEUTROPHIL TRANSENDOTHELIAL MIGRATION BY ALVEOLAR EPITHELIUM IN A DEFINED BILAYER MODEL

Within the alveolus, epithelial cells, due to their close association with endothelial cells, can potentially influence endothelial cell responsiveness during inflammation and their interaction with leukocytes. To investigate this, three lung epithelial cell lines (A549, Calu-3, or NCI-H441) were grown with endothelium on opposing surfaces of Transwell filters and the formation and stability of bilayers was rigorously evaluated. All epithelial lines disrupted endothelial monolayer formation on filters with 3- or 5-µm pores by breaching the filter, and this occurred regardless of seeding density, matrix composition, or duration of culture. Endothelial disruption was not detectable by electrical resistance or permeability measurements but required cell-specific staining with immunofluorescence and microscopy. Distinct bilayers formed only on filters with 0.4-µm pores and only with A549 cells and human umbilical vein endothelial cells. Endotoxin (lipopolysaccharide [LPS]) stimulation of bilayers (4 hours) enhanced neutrophil transendothelial migration, but this was significantly decreased compared with the response of endothelium grown alone, irrespective of whether LPS exposure was via the epithelial or endothelial side of the bilayer. Down-modulation required epithelial-endothelial approximation and was not seen when these cells were separated by 0.5 to 1 mm. This study defines optimal conditions required for generation of intact bilayers of lung epithelial cells with endothelium for the study of leukocyte-transendothelial migration. Furthermore, it was demonstrated that lung epithelial cells can modulate endothelial cell responsiveness to an environmental inflammatory stimulus such as LPS and thus may have an important role in minimizing excessive and deleterious neutrophilic inflammation in the lung alveolus.
Alloimmune response against donor glutathione S-transferase T1 antigen in renal transplant recipients.

BACKGROUND The long-term outcome of kidney transplantation could be influenced by the appearance of antibodies against donor-specific antigens. Glutathione S-transferase T1 (GSTT1) is a protein preferentially expressed in liver and kidney cells. Deletion of the GSTT1 gene results in a complete lack of protein expression, which occurs in 20% of the white population. GSTT1 donor-recipient mismatch has been deleterious in liver transplantation. The purpose of this study is to examine immunologic and clinical consequences of a GSTT1 donor-recipient mismatch in kidney transplantation. METHODS The presence of anti-GSTT1 antibodies was studied retrospectively in sera from 135 patients who underwent transplantation before 1995. Samples from 89 patients who received a GSTT1-positive kidney graft between December 1998 and May 2001 were collected prospectively. GSTT1 genotypes and anti-GSTT1 antibodies were studied by using standard methods. RESULTS Seven patients, all with the null genotype, produced anti-GSTT1 antibodies. No transplant recipient with a positive genotype produced these antibodies. Six of 7 patients with antibodies also were positive for hepatitis C virus. Clinical outcomes of these patients did not differ from those of the entire group. CONCLUSION After kidney transplantation, some patients with the null GSTT1 genotype who received a GSTT1-positive graft developed an immune response, with production of anti-GSTT1 antibodies. The presence of these antibodies did not seem to produce functional impairment in the graft. Hepatitis C virus seems to have a prominent role in this particular allograft immune response.
Microtubule Dynamics in Mitotic Spindles of Living Cells a

Observations on living, dividing cells,’” together with more recent experiments with microtubules (MTs) assembled in vitro (for review see reference 4), suggest that MTs are dynamic structures and that an understanding of this dynamic behavior is critical for an understanding of mitosis. Early work on living cells clearly demonstrated the labile equilibrium between the MT-containing spindle fibers and a cellular pool of tubulin subunits. In addition, a role for this assembly and disassembly in chromosome movement was These studies showed that the assembly of spindle MTs and their subsequent disassembly are intimately linked to the mitotic process. The pathways and regulation of tubulin association and dissociation with spindle MTs, however, were not resolved. A variety of morphological studies, performed using immunofluorescence and electron microscopy, have revealed that spindles are composed, in part, of a bipolar arrangement of MTs that radiate from the spindle poles and overlap at the metaphase plate.612 Such techniques, however, yield only static images of fixed stained cells, so the contribution of MTs to chromosome movement has remained unclear. In an effort to investigate spindle M T dynamics, we have developed techniques to introduce fluorochrome-labeled tubulin subunits into living, dividing cells to monitor tubulin behavior. This work has been carried out in collaboration with the laboratory of J . R. McIntosh (this volume p. 566). Using this approach, termed fluorescence analogue cytochemistry,” the distribution and dynamics of the tubulin subunit can be investigated in living cells, avoiding the complexities of in vitro conditions. Similar methods were initially used by Keith et a1. ,14 who observed the dynamic behavior of the interphase M T array in cultured cells. Subsequently, Wadsworth and Sloboda” demonstrated the rapid polymerization of fluorescent tubulin into M T arrays in sea urchin eggs during mitosis. These preliminary studies suggested the utility of these techniques to examine the behavior of tubulin in living cells. For our experiments, bovine brain tubulin has been covalently modified with the fluorochrome 5-(4,6-dichlorotriazin-2-yl) amino fluorescein (DTAF) and the resulting DTAF tubulin shown to retain the native characteristics of the tubulin molecule. (Details of the labeling procedures can be found in reference 16 and J. R. McIntosh, this volume p. 566). Following microinjection into suitable cells, the DTAF-tubulin has been shown to coassemble with all cytoplasmic M T containing structures in living cells. ”. 18 Thus the exogenous labeled subunits serve as “tracers” of the behavior of the endogenous tubulin pool. In initial experiments, mitotic cells were microinjected with DTAF tubulin, and
Feeding performance of king Mackerel, Scomberomorus cavalla.

Feeding performance is an organism's ability to capture and handle prey. Although bite force is a commonly used metric of feeding performance, other factors such as bite pressure and strike speed are also likely to affect prey capture. Therefore, this study investigated static bite force, dynamic speeds, and predator and prey forces resulting from ram strikes, as well as bite pressure of the king mackerel, Scomberomorus cavalla, in order to examine their relative contributions to overall feeding performance. Theoretical posterior bite force ranged from 14.0-318.7 N. Ram speed, recorded with a rod and reel incorporated with a line counter and video camera, ranged from 3.3-15.8B L/s. Impact forces on the prey ranged from 0.1-1.9 N. Bite pressure, estimated using theoretical bite forces at three gape angles and tooth cross-sectional areas, ranged from 1.7-56.9 MPa. Mass-specific bite force for king mackerel is relatively low in comparison with other bony fishes and sharks, with relatively little impact force applied to the prey during the strike. This suggests that king mackerel rely on high velocity chases and high bite pressure generated via sharp, laterally compressed teeth to maximize feeding performance.
A INFLUÊNCIA DA POLÍTICA DE DIVIDENDOS SOBRE A VOLATILIDADE DAS AÇÕES

De modo a analisar a relacao entre a politica de dividendos e o risco das acoes, mensurada pela variacao nos precos, este artigo teve por objetivo verificar como a volatilidade do preco das acoes negociadas na BM&FBOVESPA e influenciada pela politica de dividendos das corporacoes. Para o desenvolvimento do estudo, fez-se uso da analise de regressao em corte transversal, onde a amostra final e composta por 914 empresas nao financeiras, pagadoras de dividendos e listadas na BM&FBOVESPA, no periodo de 2000 a 2012. Para examinar a relacao entre a politica de dividendos e a volatilidade das acoes, foram utilizadas duas variaveis explicativas: dividend yield e o indice payout. Adicionalmente, utilizou-se como variaveis de controle a variavel tamanho, a volatilidade dos lucros, a divida de longo prazo e o crescimento dos ativos. O modelo econometrico utilizou a abordagem proposta por Baskin (1989). Como resultados principais, verificou-se que a politica de dividendos no Brasil demonstrou-se significante na determinacao da volatilidade, evidenciando que quanto mais elevado o dividend yield , menor o risco a ser enfrentado pelo acionista. Adicionalmente, como esperado, observou-se que o tamanho influenciou negativamente as oscilacoes do preco das acoes, enquanto que a divida de longo prazo e o crescimento dos ativos demonstraram um efeito direto sobre a volatilidade do preco das acoes. Ja as variaveis indice payout e volatilidade dos lucros nao apresentaram significância estatistica. Por fim, esta pesquisa contribui com novas evidencias empiricas, pois fornece informacoes relevantes sobre o risco para os investidores que utilizam a estrategia de dividendos para investir no mercado acionario.
Albumen absorption during chick embryogenesis.

In birds albumen represents a substantial part of the reserve material for their embryological development (Romanoff & Romanoff, 1949). In Gallus gallus albumen proteins form 50 % of non-incubated egg protein content (Romanoff & Romanoff, 1949). During incubation such material is absorbed and utilized, to a great extent, for the synthesis of embryonal proteins (Fiske & Boyden, 1926; Rupe & Farmer, 1955). It is not yet well understood how these processes (albumen absorption and utilization for the energetic and nutritional needs of the embryo) take place. The present available data indicate that the amount of albumen solids begins to diminish starting from 11 to 12 days of incubation (Romanoff & Romanoff, 1933; Rupe & Farmer, 1955). From 13 to 14 days, after the seroamniotic connexion perforates, the protein content of the amniotic fluid shows a marked increase because of the passage of albumen (Needham, 1931; Romanoff, 1960).
An Overview of Kidney Disease Following Hematopoietic Cell Transplantation

Hematopoietic stem cell transplantation (SCT) recipients are exposed to a large amount of anti-cancer drugs, immunosuppressors, and irradiation during the peri-SCT period. Thus, they have to overcome serious adverse events related to unavoidable but toxic procedures, including organ disorders. In particular, acute kidney injury (AKI) is one of the most critical complications, because it influences the mortality of patients. A few patients who survive AKI may develop nephrotic syndrome, and precedent AKI is also closely associated with chronic and progressive loss of the renal function in post-SCT patients. These kidney diseases place a heavy burden on SCT patients, both medically and economically. Therefore, hematologists who evaluate SCT should be fully aware of the development of these kidney diseases after SCT. We herein review the common course of kidney disease development following allogeneic SCT to provide healthcare professionals with practical information on renal disease in SCT patients.
Visibility Graph Analysis and Monumentality in the Iron Age City at Kerkenes in Central Turkey

Abstract This paper investigates symmetry and visualization at two monumental gateways excavated in the late 7th–6th centuries b.c. Phrygian city on Mount Kerkenes (Turkish: Kerkenes Dağ) in central Turkey. One of these, the Cappadocia Gate, is one of seven city gates piercing the 7 km stone-built defenses; the other is the Monumental Entrance to the Palatial Complex. We use visibility graph analysis (VGA), a branch of space syntax analysis, and viewshed isovists to demonstrate that a similar visual and symbolic conception underlay the design and furnishing of these two gates. Both were conceived to signal different messages to people entering and exiting the gates, and both manipulated the visibility of cultic statuary to achieve this effect. Other contemporaneous monuments, like the Midas Monument in the Phrygian Highlands, shared many of the same principles. VGA reveals fundamental characteristics of the experience of Phrygian monumental architecture and also indicates a degree of city planning.
The Association Between Management Earnings Forecast Errors and Accruals

ABSTRACT: We investigate the association between errors in management forecasts of subsequent year earnings and current year accruals. In an uncertain operating environment, managers' assessments of their firms' business prospects are imperfect. Since managers' imperfect business assessments influence both accruals generation and earnings projection, we hypothesize that management earnings forecasts exhibit greater optimism (pessimism) when accruals are relatively high (low). Consistent with this hypothesis, we find a positive association between management earnings forecast errors and accruals. This positive association is stronger for firms operating in a more uncertain business environment and for firms in industries exhibiting greater covariation between accruals and growth‐related activities. Moreover, this positive association is significant when accruals likely reflect managers' true beliefs about firms' business prospects, but is nonexistent when accruals are likely manipulated to boost managers' .
The American Association of Suicidology Are UN Peacekeepers at Risk for Suicide ?

Media reports connecting UN peacekeeping duties by Canadian soldiers to their subsequent suicide prompted this study of peacekeeping as suicide risk. In a case-control design we retrospectively compared 66 suicides in the Canadian military between 1990 and 1995 with two control groups: (a) 2,601 controls randomly selected from the electronic military database and (b) 66 matched controls with complete personnel and medical data. We found no increased risk of suicide in peacekeepers except among a subgroup of air force personnel. Here confounding individual factors, isolation from supports, and possibly inadequate preparation for deployment elucidated their suicides. Theater of deployment (e.g., Bosnia) did not affect the suicide rate. Military suicides experienced psychosocial stresses and psychiatric illness more often than their matched controls. We conclude that although peacekeeping per se does not increase overall suicide risk, military lifestyles may strain interpersonal relationships, encourage alcohol abuse, and contribute to psychiatric illness and suicide in a minority of vulnerable individuals irrespective of peacekeeping assignment. Careful selection, and preparatory military training that encourages intragroup bonding and mutual support, may protect against suicide risk.
Sonographic characteristics of presumptively normal main axillary and superficial cervical lymph nodes in dogs.

OBJECTIVE To evaluate the B-mode and Doppler ultrasonographic appearance of presumptively normal main axillary and large superficial cervical lymph nodes (MALNs and SCLNs, respectively) in adult dogs. ANIMALS 51 healthy adult dogs (data from 1 dog were not analyzed). PROCEDURES For each dog, weight, distance from the cranial aspect of the first sternebra to the caudal aspect of the left ischiatic tuberosity, and thoracic height and width at the level of the xiphoid process were recorded. Via B-mode and Doppler ultrasonography, echogenic characteristics, size in relation to body size and weight, and vascular supply of the MALNs and the SCLNs were evaluated (1 SCLN in 1 dog was not ultrasonographically visible). RESULTS Most MALNs were clearly margined, solitary, and ovoid; echopatterns were homogenous or cortical and hypo- to isoechoic, compared with surrounding soft tissues. Size measurements of MALNs correlated with dogs' body length, thoracic width and height, and body weight. Most SCLNs were clearly margined, fusiform, and hypoechoic (compared with surrounding soft tissues) with a cortical or homogenous echopattern. Size measurements of SCLNs correlated with dogs' body length, thoracic width and height, and body weight. In 50 of the 100 MALNs, an intranodal vascular supply was detected; in contrast, an intranodal vascular supply in SCLNs was detected infrequently. CONCLUSIONS AND CLINICAL RELEVANCE Results indicated that, in dogs, anatomically separate lymph nodes have different echogenic and vascular characteristics; body size (skeletal length, height, and width), along with body weight, were correlated with sizes of presumptively normal MALNs and SCLNs.
Clinical outcome of cadaveric renal allografts contaminated before transplantation

This analysis was performed to define the incidence of pretransplant microbial contamination of donor kidneys, and to assess the resultant morbidity including infections requiring therapy, and graft loss. Case records of all 638 renal allograft recipients patients transplanted in our centre during the period June 1990 to October 2000 were studied. All the recipients were given a single dose of intravenous antibiotics at the time of induction of anaesthesia. A total of 775 microbiology reports on perfusion fluid, kidney swabs and ureteric tissue were retrieved. Fifty‐eight of 638 (9.1%) patients were transplanted with a graft that showed preoperative contamination. 18 of these 58 patients (31%) subsequently required antibiotic treatment. Thirty of 32 patients who received kidney contaminated with skin flora had a benign course (i.e. no unexplained, no positive blood cultures or graft infection). By contrast, seven of nine recipients with grafts whose perfusion fluid yielded lactose fermenting coliforms (LFCs) required antibiotics and three of nine of them suffered graft loss as a result. Two of these patients had bacteraemia caused by LFC, and one died. Three of five patients with positive cultures due to yeast required treatment with antifungals. None of the four patients who had graft contaminated by Staphylococcus aureus became infected. One‐year 49/58 (85%) of these patients survived with functioning graft. Overall 1‐year patient survival was 53/55 (92%). These data suggest that contamination of renal allografts by LFCs or yeasts need to be treated preemptively before the onset of clinical manifestations. By contrast, contamination with skin contaminants does not pose a risk to the graft.