Miracle-dz/UniFAR-FTUs huggingface dataset:
The effectiveness of platelet-rich plasma on the skin wound healing process: A comparative experimental study in sheep

Aim: The therapeutic evaluation of the biological effect of platelet-rich plasma (PRP) used as a surgical adjunct to maintain the inflammatory process and to potentiate tissue healing, make the subject of recent research in regenerative medicine. This study was designed to evaluate the healing activity of PRP by its topical application on the skin experimentally injured in a sheep model. Materials and Methods: The study was conducted on 9 adult and clinically healthy males sheep. PRP was obtained by a protocol of double centrifugation of whole blood from each animal. After sterile skin preparation, full-thickness excisional wounds (20 mm x 20 mm) were created on the back of each animal. The animals were randomly divided into three equal groups of three sheep for each. In Group I, the wounds were treated with PRP, in Group II; wounds were treated with Asiaticoside; in Group III, wounds were treated with saline solution. The different treatments were administered topically every 3 days. Morphometric measurements of the contraction surface of the wounds and histopathological biopsies were carried out at the 3rd, 7th, 14th, 21st, and 28th days of healing. Results: The results of the morphometric data obtained revealed that it was significant differences recorded at the 7th and 14th day of healing in favor for animals of Group I. Semi-quantitative histopathological evaluation showed that PRP reduces inflammation during 3 first days post-surgical and promotes epithelialization in 3 weeks of healing. Conclusion: We concluded that topical administration of PRP obtained by double centrifugation protocol could potentially improve the skin healing process in sheep.
What is Our Perception of Project Risk, and do the Current Theories Truly Reflect Our Pragmatic Interpretation of This Perception?

Risk behavior of management and the consideration of utilities and the propensity to accept certain risks, fall into a broad field of behavior and cognitive decision-making. This paper explores the wide literature on the perception of risk (in particular project risk) and then focuses on a very narrow area of that research—the perception of the relationship between the probability of risk occurrence and its possible impact if it did occur. Through a case study approach, it concludes that the linear relationship between risk “probability” and “impact” producing a “risk value” <inline-formula><tex-math notation="LaTeX">${\text{(RV}} = {\text{P}\,\text{x}\,\text{I)}}$</tex-math></inline-formula> may not be “perceived” to be correct and that the relationship may, in fact, be exponentially influenced.
Mobile Instant Video Clip Sharing With Screen Scrolling: Measurement and Enhancement

Today's multimedia content generation and sharing have been dramatically boosted by the deep penetration of broadband wireless accesses and the much improved processing power of smart mobile terminals. Mobile users can now instantly capture and share short video clips (usually of several seconds) anywhere and anytime, and consume them with convenient touch screen operations. The instant video clip sharing has emerged as a mainstream application; such pioneers as Twitter's Vine, Miaopai, Instagram, and Snapchat have seen great acceptance, particularly by the youth community. In this paper, we present an initial study on instant video clip sharing. Taking Twitter's Vine as a representative, we systematically investigate its distinct mobile interface, service framework, and user watching behaviors, revealing how this mainstream multimedia service type differentiates from its traditional counterparts. Our trace measurement and analysis demonstrate that instant mobile video clips have a much shorter lifespan and highly skewed popularity that quickly decays over time. This is further aggravated by the unique screen scrolling operation for video browsing. As such, the download-and-watch scheduling used by existing platforms can hardly achieve quality user experience and cost efficiency. We closely investigate and model the input user gestures for scrolling, including drag and fling, and analyze the scheduling policy, partitioning it into prefetching scheduling and watch-time download scheduling. We develop effective solutions toward both subproblems as well as their integration with screen scrolling. The superiority of our enhancement is demonstrated by extensive trace-driven evaluation.
Nanostructured lipid carriers co-delivering lapachone and doxorubicin for overcoming multidrug resistance in breast cancer therapy

Background Multidrug resistance is responsible for the poor outcome in breast cancer therapy. Lapa is a novel therapeutic agent that generates ROS through the catalysis of the NAD(P) H:quinone oxidoreductase-1 (NQO1) enzyme which significantly facilitate the intracellular accumulation of the co-delivered DOX to overcome MDR in cancer cells. Purpose Herein, in our study, nanostructured lipid carrier (NLC) co-delivering β-lapachone (Lapa) and doxorubicin (DOX) was developed (LDNLC) with the aim to overcome the multidrug resistance (MDR) in breast cancer therapy. Patients and methods Lapa and DOX were loaded into NLC to prepare LDNLC using melted ultrasonic dispersion method. Results The well designed LDNLC was nanoscaled particles that exhibited preferable stability in physiological environment. In vitro cell experiments on MCF-7 ADR cells showed increased DOX retention as compared to DOX mono-delivery NLC (DNLC). In vivo anti-cancer assays on MCF-7 ADR tumor bearing mice model also revealed significantly enhanced efficacy of LDNLC than mono-delivery NLCs (DNLC and LNLC). Conclusion LDNLC might be a promising platform for effective breast cancer therapy.
An Extremely High Efficient Three-Level Active Neutral-Point-Clamped Converter Comprising SiC and Si Hybrid Power Stages

Three-level converters typically feature low switching loss and small filter size. In order to realize a high-power-density design for three-level converters, SiC MOSFETs may be selected instead of using Si insulated-gate bipolar transistors. However, all-SiC-MOSFET-based converters suffer from extremely high total cost. In this paper, a SiC MOSFET and Si device hybrid active neutral-point-clamped (ANPC) converter is proposed. It consists of four Si active switches and only two SiC MOSFETs. Thus, it has lower total cost compared to the all-SiC-MOSFET-based ANPC converter. Furthermore, a dedicated modulation scheme is proposed to completely move all the switching events from Si devices to SiC MOSFETs by using redundant switching states. As a result, the switching losses are significantly reduced and extremely high efficiency is achieved. The proposed converter has fully utilized the low-switching-loss advantage of SiC MOSFETs and the low-cost advantage of Si devices, which shows significant superiority in high-end grid-connected inverter and rectifier applications.
Modeling and Verification of a Six-Phase Interior Permanent Magnet Synchronous Motor

In this paper, a new mathematical modeling for a six-phase interior permanent magnet synchronous motor (IPMSM) is presented. The proposed model utilizes two synchronous reference frames. First, the flux model in the <inline-formula> <tex-math notation="LaTeX">$abcxyz$</tex-math></inline-formula> frame is mapped into the stationary <inline-formula> <tex-math notation="LaTeX">$dq$</tex-math></inline-formula> frames and then to two synchronous rotating frames. Then, differentiating the flux models, voltage equations are derived in rotating frames. Through this analysis, the interaction between the <inline-formula><tex-math notation="LaTeX">$abc$</tex-math></inline-formula> and <inline-formula><tex-math notation="LaTeX">$xyz$</tex-math></inline-formula> subsystems is properly described by a coupling matrix. The torque equation is also derived using the two reference current variables. Flux model was verified through FEM analysis. Experiments were done using a 100 kW six-phase IPMSM in a dynamo system. The validity of the torque equation was checked with some experimental results under a shorted condition on an <inline-formula><tex-math notation="LaTeX">$xyz$</tex-math></inline-formula> subsystem.
Effect of immobilized fungal phytase on growth performance and bone traits of broilers fed with low dietary calcium and phosphorus

Aim: The aim of this study was to investigate the effects of phytase which was laboratory produced by Aspergillus foetidus on the growth performance, mineral retention, and bone traits of broilers fed with low dietary calcium and phosphorus. Materials and Methods: The extracellular phytase enzyme secreted into the crude filtrate was concentrated by ammonium sulfate precipitation to obtain an activity of 500 phytase units (FTU). A total of 90 1-day-old chicks (Cobb 500) were randomly divided into three treatment groups with five replicates having six birds each. Dietary treatment, T1, was with 0.45% non-phytate P (NPP) during starter and 0.40% during finisher phase with 1% Ca. Dietary treatment, T2, had 0.37% NPP during starter and 0.32% in finisher phase with 1% Ca and supplemental lab phytase at 500 FTU/kg. Dietary treatment, T3, was similar to T2 with a lower Ca of 0.8%. Results: There was no significant difference among the dietary treatments with regard to body weight gain, feed intake, feed conversion ratio, and Ca retention (p>0.05). However, a significant improvement in retention of P by birds was observed in phytase supplemental groups T2 and T3 (p<0.05). Dry weight of tibia (2.58-2.78 g/kg live weight) and ash content (39.7-41.8%) was comparable among treatments. A similar trend was observed for bone Ca, P, and Mn content. Conclusion: The study indicated that 500 FTU/kg phytase can be effectively supplemented in a broiler diet with low phosphorus (0.37% in starter and 0.32% NPP in finisher diet) and low calcium (0.8% in diet) for better growth performance and with successful replacement of dietary P by 0.08 % and reduced P excretion into the environment in broiler chicken.
A Stator Current Oriented Closed-Loop $I\text{--} f$  Control of Sensorless SPMSM With Fully Unknown Parameters for Reverse Rotation Prevention

For the defects of speed oscillation, fixed current amplitude and inclined to lose synchronism in open-loop <inline-formula><tex-math notation="LaTeX">$I\,\text{--}\, f$</tex-math></inline-formula> control approach, a new stator current vector oriented closed-loop <inline-formula><tex-math notation="LaTeX">$I\,\text{--}\, f$</tex-math> </inline-formula> control scenario is proposed for surface-mounted permanent magnet synchronous motor (SPMSM) with fully unknown parameters. In a stator current vector oriented coordinate system <inline-formula> <tex-math notation="LaTeX">$d^{{\ast }}q^{{\ast }}o$</tex-math></inline-formula>, the dynamic model of SPMSM is established. Based on analysis of control performance for conventional open-loop <inline-formula> <tex-math notation="LaTeX">$I\,\text{--}\, f$</tex-math></inline-formula> control, the control framework of closed-loop <inline-formula><tex-math notation="LaTeX">$I\,\text{--}\, f$</tex-math></inline-formula> control is presented and closed-loop regulators of angle, speed, and current are derived. Additionally, the adaptation law estimating totally unknown parameters of SPMSM is simultaneously accomplished in the design of controller and avoids construction of estimation algorithm separately. The stability of the controller is proved in the sense of Lyapunov theory. The validity of the proposed algorithm is verified through both simulations and hardware experiments. The results indicate that the improved control scheme ensures the speed to track the expected value rapidly and stably in different load conditions, and the current amplitude is regulated to enlarge with the increasing of load torque automatically. Furthermore, fully unknown parameters are estimated precisely and reverse rotation of motor at startup enables to be prevented effectively.
Three-Phase PLLs by Using Frequency Adaptive Multiple Delayed Signal Cancellation Prefilters Under Adverse Grid Conditions

Phase-locked loops (PLLs) are the most widely adopted techniques for synchronization of distributed generation units to the utility grid. However, when the grid voltage is polluted with severe unbalances and harmonics, the accuracy and performance of the conventional PLL will be deteriorated. This paper proposes a novel filtering technique, called the multiple delayed signal cancellation (MDSC), for improving the dynamic performance of the conventional synchronous reference frame (SRF)-PLL under adverse three-phase grid conditions. Theoretical developments of $dq$-frame and $\alpha \beta$-frame MDSC operators are investigated. The analysis shows that these MDSC operators can provide more flexibility to configure the lowest undesired harmonics. Since the MDSC operators possess multiple delayed signals in parallel, the delay time introduced by the operators can be reduced by selecting a suitable number of transfer delays. Therefore, the MDSC operators can be configured to have less delay time in comparison with the cascaded delayed signal cancellation operators with the same harmonic elimination capability. These two MDSC operators are utilized as a prefiltering stage to the conventional SRF-PLL to improve the dynamic responses. Since MDSC operators are dependent on grid frequency excursions, a new frequency adaptation scheme for the MDSC operators is also proposed for providing fast grid frequency estimations in designing the MDSC prefilter based PLLs. Experimental verifications demonstrate the effectiveness of the proposed PLLs and provide good dynamic responses when compared with the recent advanced PLLs.
Uptake and transport of pullulan acetate nanoparticles in the BeWo b30 placental barrier cell model

Introduction Nanomedicine has shown a great potential in perinatal medicine because of its characteristics of sustained, controlled release and targeting ability; on the other hand, it may also lead to unexpected toxicities such as embryotoxicity and even malformation after crossing the placental barrier, but data concerning transplacental transport are scarce. Pullulan acetate (PA) nanoparticles (NPs) are a promising nanocarrier derived from natural polysaccharide; however, their transplacental transport ability and mechanism are unknown. Materials and methods In this study, fluorescein isothiocyanate (FITC) conjugated PA (PA-FITC) was synthesized. PA-FITC NPs were characterized by dynamic light scattering, transmission electron microscopy (TEM) and scanning electron microscopy (SEM). The cytotoxicity of PA-FITC NPs at concentrations of 15, 30, 60, 125, 250, 500, 1,000 and 2,000 μg/mL was studied by cell counting kit-8. The human chorionic gonadotrophin (HCG) cytokine assay was conducted to evaluate the biological function of BeWo b30 cells. Endocytic mechanisms of PA-FITC NPs were investigated via fluorescence analysis. The monolayer properties were characterized by TEM, tight junction staining, transepithelial electrical resistance and fluorescein sodium transportation. The transport ability was measured in the cell based transwell model by confocal imaging and SEM. Results PA-FITC NPs were almost spherical shape with a size range of 200–300 nm. Cell viability of BeWo b30 cells was up to 100% in all groups. The concentrations of HCG increased with increasing numbers of cells and culture time, which showed the good biological function of BeWo b30 cells. PA-FITC NPs were rapidly endocytosed through caveolae-mediated endocytosis and pinocytosis, with uptake inhibition rates with nystatin (NY) and colchicines (Col) of 55% and 51% respectively. BeWo b30 cell monolayer was formed over 5 days. PA-FITC NPs were found in the cytoplasm of cells on the transwell membranes; while some NPs were found in the basolateral (fetal) compartment over 24 h. Conclusion In summary, PA-FITC NPs are nontoxic, can cross the blood-placental barrier, and show mainly internalization to BeWo b30 cells through caveolae-mediated endocytosis and pinocytosis pathways, major via the former pathway. The results could benefit the adjustment and control of the transplacental transport of nanomedicines.
Power Decoupling for Single-Phase PV System Using  $\acute{\mathrm{C}}$uk Derived Microinverter

This paper reports an elegant approach to address two major challenges of transformerless grid-connected microinverters, common-mode earth leakage current and double-frequency power pulsation across the photovoltaic (PV) terminal. The proposed solution uses an embedded decoupling capacitor in a doubly grounded boost–buck ( $\acute{\mathrm{C}}$uk) derived topology. An intelligent switching scheme ensures that a large swing of the decoupling capacitor voltage is easily accommodated. Thus, film capacitors can be used instead of electrolytic capacitors, which helps increase equipment lifetime. Details of circuit operation are provided along with dynamic modeling and controller design for close-loop operation. Simulation and experimental results are presented for performance validation of the microinverter.
Mutant Quality Indicators

The question of which are the valuable mutants has received little attention in mutation testing literature. Naturally, the choice of mutants impacts the quality of the performed analysis and has the potential of changing the conclusions of empirical studies. To this end, we collect definitions related to mutant quality indicators and analyse their relations. We identify two classes of indicators, related to individual mutants (Fault Revealing, Subsuming, Hard-to-kill and Stubborn) and to mutant sets (disjoint/dominator and distinguished). We analyse a large set of mutants from 3,902 (real) faulty program versions, belonging to 40 fault classes, collected from an on-line programming contest. Our analysis categorises mutants as valuable, according to the studied quality indicators, profiles their types and examines the relations between them. Our results suggest that there is a large disagreement between the indicators and that the connection between mutant type, its quality and its ability to reveal faults is weak. Additionally, our paper reveals that the ability of mutants to uncover faults differs significantly across the different fault classes and that some mutant types are well linked (or completely disconnected) to specific fault classes.
On-Chip Optical Channel Routing for Signal Loss Minimization

To satisfy the performance requirement in modern very large-scale integration designs, on-chip optical integration is a potential and developing technology in delay and power consideration. After completing the placement of the used optical devices in an optical layer, an optical routing plane can be divided into a set of horizontal or vertical optical channels. Based on the exploration of different routing geometries in optical planar routing, optical signal loss including length loss, bend loss, and crossing loss can be treated as the penalty of a routing result in optical planar routing. In this paper, a new grid-based non-Manhattan routing model is first proposed to assign the possible routing paths for optical interconnects. Furthermore, given a set of two-pin optical nets inside an optical channel in our proposed grid-based routing model, based on the optimality-oriented swap pass in Yan’s hierarchical bubble sorting, an efficient channel router can be proposed to complete the connection of the given optical nets with minimizing the total signal loss on the given nets inside an optical channel. Compared with Condrat’s swap-based channel router, the experimental results show that our proposed channel router decreases 41.08% of the total bend loss, 13.17% of the worst signal loss, and 23.57% of the total signal loss under the same total crossing loss on the average for ten tested examples in reasonable CPU time. Besides that, the experimental results show that our proposed channel router reduces 8.2% of the total wire length, 51.40% of the total routing tracks, and 9.98% of the total routing area for ten tested examples in reasonable CPU time.
Characterization of Conductivity Changes During High-Frequency Irreversible Electroporation for Treatment Planning

For irreversible-electroporation (IRE)-based therapies, the underlying electric field distribution in the target tissue is influenced by the electroporation-induced conductivity changes and is important for predicting the treatment zone. Objective: In this study, we characterized the liver tissue conductivity changes during high-frequency irreversible electroporation (H-FIRE) treatments of widths 5 and 10 μs and proposed a method for predicting the ablation zones. Methods: To achieve this, we created a finite-element model of the tissue treated with H-FIRE and IRE pulses based on experiments conducted in an in-vivo rabbit liver study. We performed a parametric sweep on a Heaviside function that captured the tissue conductivity versus electric field behavior to yield a model current close to the experimental current during the first burst/pulse. A temperature module was added to account for the current increase in subsequent bursts/pulses. The evolution of the electric field at the end of the treatment was overlaid on the experimental ablation zones determined from hematoxylin and eosin staining to find the field thresholds of ablation. Results: Dynamic conductivity curves that provided a statistically significant relation between the model and experimental results were determined for H-FIRE. In addition, the field thresholds of ablation were obtained for the tested H-FIRE parameters. Conclusion: The proposed numerical model can simulate the electroporation process during H-FIRE. Significance: The treatment planning method developed in this study can be translated to H-FIRE treatments of different widths and for different tissue types.
Bitcoin Mixing Detection Using Deep Autoencoder

Bitcoin is a decentralized transaction platform and the largest cryptocurrency system. Bitcoin represents a chain of blocks containing its entire legal transaction history, thereby providing convenience for tracking money. However, mixing services are used as an effective means to hide the identity of a transaction address by combining several transfers from different users. Detecting the original user of a Bitcoin address and the money flow is essential in some special circumstances such as anomaly detection. Recognizing Bitcoin mixing services and de-mixing user accounts have only rarely been studied. Here we demonstrate that Bitcoin transaction graphs possess community properties and that a mixing service can be regarded as a cluster outlier. Motivated by the success of graph embedding in social network analysis, we propose a feature-based method to identify mixing services, testing our method on the real Bitcoin ledger.