Miracle-dz/UniFAR-FTUs huggingface dataset:
The acute diabetic Charcot foot managed on the basis of magnetic resonance imaging--a review of 71 cases.

BACKGROUND Acute Charcot foot (ACF) is a skeletal breakdown associated with inflammatory swelling of a foot in patients with pain insensitivity, such as diabetic neuropathy. In ACF stage 0, skeletal pathology (e.g. osseous oedema) is visible on magnetic resonance imaging (MRI), but not on plain radiographs. Continued unprotected walking invariably causes stage 1 (complex cortical fractures). Treatment by total contact cast (TCC) is of limited benefit if X-ray-based. The benefits of MRI-based TCC treatment are unknown. AIM To assess the impact of MRI, all cases of ACF diagnosed by MRI between 2000 and 2012 were reviewed. METHOD Audit of medical charts of a single outpatient diabetic foot clinic. RESULTS Seventy-one cases (59 patients) were retrieved. Diagnosis of stage 0 (n = 27 cases) and stage 1 (n = 44 cases) was established one and two months (medians) after symptom onset, respectively. Unremarkable radiographs, that were not cross-checked by MRI (n = 13 cases), misled primary care physicians to postpone referral until five months after symptom onset, when cortical fractures had already occurred in 12 cases. Midfoot (Chopart- and Lisfranc-) lesions healed better in stage 0 versus stage 1 (69% versus 7% without deformities, p = 0.0012), while forefoot (metatarsal) lesions healed well in either stage (100% versus 75% without deformities). TCC-treatment lasted four to six months. CONCLUSION Healing of ACF was more efficient in stage 0 than in stage 1. Expeditious MR imaging was indispensable to diagnose stage 0 in a swollen foot of a neuropathic patient, while unremarkable X-rays often led to a missed diagnosis.
Comparison of MRI and DXA to measure muscle size and age-related atrophy in thigh muscles.

OBJECTIVES Magnetic resonance imaging (MRI) and dual-energy x-ray absorptiometry (DXA) were used to examine the thigh lean mass in young and old men and women. METHODS A whole-body DXA scan was used to estimate thigh lean mass in young (20 men; 22.4±3.1y; 18 women; 22.1±2.0y) and older adults (25 men; 72.3±4.9y; 28 women; 72.0±4.5y). Thigh lean mass determined with a thigh scan on the DXA or full thigh MRI scans were compared. RESULTS Although the thigh lean mass quantified by DXA and MRI in young and older participants were correlated (R(2)=0.88; p<0.001) the magnitude of the differences in thigh lean mass between young and old was smaller with DXA than MRI (old vs. young men 79.5±13.1% and 73.4±11.2%; old vs. young women 88.6±11.8% and 79.4±12.3%, respectively). Detailed analysis of MRI revealed 30% smaller quadriceps muscles in the older than young individuals, while the other thigh muscles were only 18% smaller. CONCLUSIONS DXA underestimates the age-related loss of thigh muscle mass in comparison to MRI. The quadriceps muscles were more susceptible to age-related atrophy compared with other thigh muscles.
Toward sustainable forest management indicators? A data mining approach to evaluate the impact of silvicultural practices on stand structure

ABSTRACT Indicators are increasingly required to support a fine-tuning between sustainable forestry and multiple environmental targets. A data mining strategy was implemented in this study to assess the overall impact of traditional and innovative silviculture on stand structure in a sample of beech forests with varying dominant age, management history and stand structure in Italy. Harvesting intensity and stand sensitivity to treatment were investigated using a principal component analysis (PCA) run on a set of dendrometric and stand-structure variables measured before and after practice implementation at the scale of forest compartment. The PCA decomposed the overall impact of silviculture on forest structure in two manipulative effects: (i) structural changes between control and treatments, and (ii) the net manipulative effect of innovative versus traditional treatment. Our approach informs the sustainable management of forests, outlining between-site differences in stand structure and identifying a diversity gradient shaped by silvicultural practices. Multivariate analysis of forest indicators following practice’s implementation is a promising tool to design innovative silviculture coherent with conservation of forests’ structural diversity.
Multiobjective evacuation route assignment model based on genetic algorithm

Emergency evacuation in public places becomes a research focus in recent decades. One major objective of evacuation is to maximize the efficiency of the whole evacuation system. The paper proposes a multiobjective evacuation route assignment model to plan an optimal egress route set for the individual evacuees. The three objectives in the proposed model are to minimize the total evacuation time, minimize the total travel distance of all the evacuees and minimize the congestion during the evacuation process. These objectives need to be satisfied simultaneously while some of them conflict with each other. The travel speed on each road segment is related with the time and the number of evacuees on it during a certain time period. The congestion of a road segment is modeled as the density of evacuees passing it in time and space dimensions. The evacuation route assignment problem can be treated as a combinatorial optimization problem. A multiobjective optimization model based genetic algorithm is adopted to solve the proposed evacuation routing problem. Wuhan Sport Center in Wuhan city of China was taken as the experiment scenario to test the performance of the proposed algorithm. The results showed that it can provide some system optimal evacuation plans. Meanwhile, the multi-objective optimization model based genetic algorithm can produce a pareto optimal set rather than single optimal point, thus the model can give alternative strategies for the evacuation policy makers.
Combined Oral Lysine Acetylsalicylate and Metoclopramide in the Acute Treatment of Migraine: A Multicentre Double-Blind Placebo-Controlled Study

This multicentre, double-blind, randomized, placebo-controlled, parallel study was designed to evaluate the efficacy of combined oral lysine acetylsalicylate and metoclopramide (LAS-MCP) in the acute treatment of migraine attacks. A total of 266 patients, 18–65 years old, with two to six attacks of migraine with or without aura (IHS criteria) per month were included. The patients had to treat two migraine attacks with LAS-MCP (1620 mg lysine acetylsalicylate-the equivalent of 900 mg aspirin- combined with 10 mg metoclopramide) or placebo. The main outcome measure was headache relief (reduction in headache severity from grade 3 or 2-severe or moderate-to grade 1 or 0-mild or none) 2 h after treatment. LAS-MCP was superior to placebo for headache relief (56% vs 28%) and for the following secondary outcome measures: complete headache relief (18% vs 7%; p < 0.001), nausea (28% vs 44%; p < 0.001), vomiting (3% vs 11%; p = 0.001), use of rescue medication (47% vs 68%; p < 0.001), global efficacy judged as good or excellent (32% vs 14%; p < 0.001). The tolerability was considered as good in 94% of treated attacks in both groups. Combined oral lysine acetylsalicylate and metoclopramide is an effective and well-tolerated acute treatment of migraine attacks.
A new robust copyright protection scheme for digital image based on visual cryptography

In this paper, a new digital image copyright protection scheme based on visual cryptography is proposed. Based on a more detailed feature classification in the discrete wavelet transform domain, an expanded code-book is used to improve the security of the current related schemes. Moreover, there is no need to modify the original image to be protected, which providing an obvious advantage when the image itself does not give permission for alteration. Experimental results show that the proposed scheme is robust against many common image processing attacks, such as JPEG compression, noise addition, cropping, rotation, scaling.
Juvenile arthritis and autoimmunity to type II collagen.

OBJECTIVE Joint inflammation in juvenile rheumatoid arthritis (JRA) is sometimes associated with an autoimmune response to type II collagen (CII), a cartilage-specific protein. To test the hypothesis that down-regulation of autoimmunity to CII can be accomplished in JRA by oral administration of CII, an open-label study of CII was performed in 9 patients with JRA. METHODS Seven rheumatoid factor-negative JRA patients with polyarticular disease and 2 JRA patients with pauciarticular disease (1 with early onset and 1 with late onset) were treated for 3 months with oral bovine CII. Patients were examined for disease activity and underwent routine laboratory testing at monthly intervals. Two of the patients had flares of disease when treatment was discontinued, and these patients were re-treated for an additional 3 months. To test the hypothesis that oral tolerance induces an immune deviation of T cells, peripheral blood mononuclear cells from patients were collected before and after treatment and cultured with CII. Supernatants and RNA were collected and analyzed for the presence of various cytokines. RESULTS Eight patient trials met the criteria for clinical improvement outlined by Giannini and coworkers in 1997. None of the patients had any side effects from the treatment. In 6 of the 8 patients who improved, interferon-gamma production decreased after oral CII therapy, correlating with clinical improvement, while 6 patients had increases in levels of transforming growth factor beta3. CONCLUSION These results are encouraging. The possible beneficial effect of oral CII in JRA merits further investigation.
Analysis of HFE Genes C282Y, H63D, and S65D in Patients With Hyperferritinemia From Northeastern Brazil

Hereditary hemochromatosis (HH) is a genetic disease caused by the high absorption and deposition of iron in several organs. This accumulation results in several clinical complications such as cirrhosis, arthritis, cardiopathies, diabetes, sexual disorders, and skin darkening. The H63D and C282Y mutations are well defined in the HH etiology. The objective of this article is identification of the H63D and C282Y mutations in the HFE protein gene and the frequency assessment of these mutations in patients with persistent increase of serum ferritin in patients from Natal City from state of Rio Grande do Norte, located in northeastern Brazil.
Intracarotid 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine Administration: Biochemical and Behavioral Observations in a Primate Model of Hemiparkinsonism

Cynomolgus monkeys received intracarotid injections of the neurotoxin 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) to produce a chronic unilateral model of parkinsonism. Extensive dopamine (DA) depletion was observed in the caudate nucleus and putamen on the side ipsilateral to the injection and this was associated with contralateral tremor, rigidity, and bradykinesia. A dose of 1.25 mg of MPTP caused ipsilateral DA loss of 99.4% in the caudate nucleus, 99.8% in the putamen, and 74.2% in the nucleus accumbens. A dose of 2.5 mg caused ipsilateral DA depletion of 99.3% in the caudate nucleus, 99.5% in putamen, and 90.1% in the nucleus accumbens. The unilateral aspect of the lesion was dose sensitive, with the 2.5‐mg dose causing bilateral asymmetric DA depletion. Tissue concentrations of serotonin were not affected by the toxin. These findings confirm that intracarotid injection of MPTP may produce a useful primate model of hemiparkinsonism that can be associated with selective unilateral DA depletion when the appropriate dose of toxin is used.
Prevalence and determinants of hyperuricemia in middle-aged, urban Chinese men.

BACKGROUND Hyperuricemia is associated with metabolic syndrome and has emerged as a marker for both type 2 diabetes and cardiovascular disease. We estimated the prevalence and lifestyle risk factors of hyperuricemia in middle-aged, urban Chinese men. METHODS The study included 3,978 urban Chinese men 40-74 years of age from a population-based cohort study, the Shanghai Men's Health Study, who were free of type 2 diabetes at baseline and had provided fasting blood samples. Uric acid concentrations were measured by the uricase method. Hyperuricemia was defined as >7.0 mg/dL. Anthropometric measurements and information on lifestyle factors and disease history were collected by in-person interviews. RESULTS One quarter of the study subjects had hyperuricemia. Participants with metabolic syndrome had a higher prevalence of hyperuricemia. Body mass index (BMI), waist-to-hip ratio (WHR), waist circumference, and weight gain (since age 20) were positively associated with the prevalence of hyperuricemia. Physical activity was inversely related to the prevalence of hyperuricemia. The odds ratios for hyperuricemia for quintiles of nonoccupational physical activity were 1.00, 0.80, 0.73, 0.75, and 0.57 (P trend <0.001). Participants with hyperuricemia were less likely to be current smokers, but were more likely to drink alcohol regularly. Beer consumption was associated with higher risk of hyperuricemia compared with consumption of wine or liquor. CONCLUSIONS In this representative sample of middle-aged, urban Chinese men, hyperuricemia is highly prevalent. Obesity, weight gain in adulthood, and alcohol intake were associated with a higher prevalence of hyperuricemia, whereas daily physical activity and smoking were inversely related to the prevalence of hyperuricemia.
Women struggle to secure land rights

Felitus Kures is a widow living in Kapchorwa, northeastern Uganda. Her husband’s death left her solely responsible for their children. To meet their needs, she depended on the small piece of land she and her husband had farmed together. But just months after his funeral, her in-laws sold her husband’s land without her knowledge. “We only realized this when the buyer came to evict us,” Ms. Kures explains. She was able to regain use of the land after she got legal assistance with the help of the Uganda Land Alliance, a civil society group that campaigns for land rights.
Probable Campylobacter fetus subsp. fetus gastroenteritis

Three strains of Campylobacter fetus subsp. fetus isolated from cases of gastroenteritis are reported. DNA-DNA hybridizations in addition to biochemical tests were used to confirm the identification of the isolates as C. fetus since all strains grew at 42 degrees C. These isolates, like other C. fetus strains, are susceptible to cephalothin and thus would not have been detected in laboratories with Campylobacter isolation media containing this component.
TRADE LIBERALIZATION AND LABOR MARKET ADJUSTMENTS IN VIETNAMESE MANUFACTURING

Using both industry and firm level data sets during the period 2003-2008, this paper provides the first comprehensive investigation of the impact of trade liberalization on employment and wages in Vietnamese manufacturing. Overall, we find empirical evidence that trade liberalization has a negative effect on employment and wages. However, the impact magnitude is modest with a decline within 2.4%-3.5% in real wages and 0.76% and 0.17% reductions in industry and firm employment respectively on average over the period. We further investigate the effects of trade liberalization on gender and skill earning gaps and the role of trade unions by location. The analysis shows that trade liberalization appears to reduce the gender and skill earnings differentials.
Government incentive strategies and private capital participation in China’s Shale gas development

ABSTRACT Shale gas development investments are uncertain and irreversible in the initial stage in China. Flexible incentive strategy is needed for governments to guide private capital participation at different development stages. This study aims to provide analysis governments can use to encourage private investment in shale gas projects according to its plans in an extended real options framework. A social benefits variable is introduced to determine the threshold of social benefits that determine whether the government will choose a deferred or instant incentives strategy. By considering the efficiency factor, we show the optimal arrangements of two kinds of incentives: tax cuts and production subsidies, to implement incentive targets. The results indicate that current market demand and social benefits are the key factors that affect the government’s choice of incentive strategy. We also find that the optimal level of incentives, either tax cuts or production subsidies, are independent of current market demand and future market uncertainty under the delayed incentive strategy, but which affect the optimal level of incentives under the instant motivation strategy, and ignoring the negative influence of unpredictable random events on future market demand might lead to insufficient government incentives in this case.
Efficient Lentiviral Transduction and Improved Engraftment of Human Bone Marrow Mesenchymal Cells

Human bone marrow (BM) mesenchymal stem/progenitor cells are potentially attractive targets for ex vivo gene therapy. The potential of lentiviral vectors for transducing BM mesenchymal cells was examined using a self‐inactivating vector that expressed the green fluorescent protein (GFP) from an internal cytomegalovirus (CMV) promoter. This vector was compared with oncoretroviral vectors expressing GFP from the CMV promoter or a modified long‐terminal repeat that had been optimized for long‐term expression in stem cells. The percentage of GFP‐positive cells was consistently higher following lentiviral versus oncoretroviral transduction, consistent with increased GFP mRNA levels and increased gene transfer efficiency measured by polymerase chain reaction and Southern blot analysis. In vitro GFP and FVIII expression lasted for several months post‐transduction, although expression slowly declined. The transduced cells retained their stem/progenitor cell properties since they were still capable of differentiating along adipogenic and osteogenic lineages in vitro while maintaining high GFP and FVIII expression levels. Implantation of lentivirally transduced human BM mesenchymal cells using collagen scaffolds into immunodeficient mice resulted in efficient engraftment of gene‐engineered cells and long‐term transgene expression in vivo. These biocompatible BM mesenchymal implants represent a reversible, safe, and versatile protein delivery approach because they can be retrieved in the event of an unexpected adverse reaction or when expression of the protein of interest is no longer required. In conclusion, efficient gene delivery with lentiviral vectors in conjunction with the use of bioengineered reversible scaffolds improves the therapeutic prospects of this novel approach for gene therapy, protein delivery, or tissue engineering.
On fractionally-spaced equalizer design for digital microwave radio channels

Advances in blind identification of fractionally-spaced models for digital communication channels and blind fractionally-spaced equalizer adaptation rely on the assumption that the time span chosen for the fractionally-spaced equalizer exceeds that of the channel. This paper considers time-domain design formulas minimizing the mean-squared symbol recovery error achieved by a finite-length FIR fractionally-spaced equalizer with a time span shorter than the channel impulse response time span for white zero-mean QAM sources in the presence of white zero-mean channel noise. For minimum mean-squared error designs the symbol error rates achievable are plotted versus the ratio of the source variance to the channel noise variance (with the channel model power normalized to achieve a received signal of unit variance) for different fractionally-spaced equalizer lengths on 64-QAM for several T/2-spaced channel models derived from experimental data. Our intent is to fuel the ongoing debate about fractionally-spaced equalizer length selection.
Pharmacodynamic Studies on the Angiotensin II Type 1 Antagonists Irbesartan and Candesartan Based on Angiotensin II Dose Response in Humans

The in vivo effects of two unsurmountable angiotensin II type 1 (AT1) antagonists, irbesartan (150 mg) and candesartan (8 mg), were studied in a double-blind, randomized, crossover study in 18 healthy men. The drugs' direct vascular effects were assessed as the rightward shift (dose ratio − 1) of angiotensin dose-effect curves on diastolic blood pressure (DBP). Renal and adrenal effects were assessed by plasma renin activity (PRA), aldosterone concentrations, and antagonistic concentration equivalents (n × Ki) in a radioligand rat lung receptor assay. Both drugs exerted similar substantial (> 30-fold) and long-lasting (> 2-fold 47 h after dosing) rightward shifts of the angiotensin II dose effect declining with half-lives of 15 h irbesartan and 12 h candesartan, respectively. Dose ratio − 1 versus n × Ki showed a linear relationship in Schild regression plots; both drugs increased PRA, decreased DBP, and suppressed aldosterone. The slopes of linear relationship between angiotensin antagonism (dose ratio − 1) and PRA increase were almost threefold steeper (p = 0.005) following irbesartan as compared with candesartan. The findings suggest that for the same degree of angiotensin II antagonism, irbesartan produces a greater increase in PRA than candesartan. These pharmacodynamic differences warrant further investigation and clarification.
A synthetic lethal screen identifies SLK1, a novel protein kinase homolog implicated in yeast cell morphogenesis and cell growth

The Saccharomyces cerevisiae SPA2 protein localizes at sites involved in polarized cell growth in budding cells and mating cells. spa2 mutants have defects in projection formation during mating but are healthy during vegetative growth. A synthetic lethal screen was devised to identify mutants that require the SPA2 gene for vegetative growth. One mutant, called slk-1 (for synthetic lethal kinase), has been characterized extensively. The SLK1 gene has been cloned, and sequence analysis predicts that the SLK1 protein is 1,478 amino acid residues in length. Approximately 300 amino acids at the carboxy terminus exhibit sequence similarity with the catalytic domains of protein kinases. Disruption mutations have been constructed in the SLK1 gene. slk1 null mutants cannot grow at 37 degrees C, but many cells can grow at 30, 24, and 17 degrees C. Dead slk1 mutant cells usually have aberrant cell morphologies, and many cells are very small, approximately one-half the diameter of wild-type cells. Surviving slk1 cells also exhibit morphogenic defects; these cells are impaired in their ability to form projections upon exposure to mating pheromones. During vegetative growth, a higher fraction of slk1 cells are unbudded compared with wild-type cells, and under nutrient limiting conditions, slk1 cells exhibit defects in cell cycle arrest. The different slk1 mutant defects are partially rescued by an extra copy of the SSD1/SRK1 gene. SSD1/SRK1 has been independently isolated as a suppressor of mutations in genes involved in growth control, sit4, pde2, bcy1, and ins1 (A. Sutton, D. Immanuel, and K.T. Arnat, Mol. Cell. Biol. 11:2133-2148, 1991; R.B. Wilson, A.A. Brenner, T.B. White, M.J. Engler, J.P. Gaughran, and K. Tatchell, Mol. Cell. Biol. 11:3369-3373, 1991). These data suggest that SLK1 plays a role in both cell morphogenesis and the control of cell growth. We speculate that SLK1 may be a regulatory link for these two cellular processes.