Miracle-dz/UniFAR-FTUs huggingface dataset:
Worry, desire, and sexual satisfaction and their association with severity of ED and age.

INTRODUCTION This study evaluates worry about sexual and relationship functioning, sexual desire, and sexual satisfaction as indicators of sexual quality of life in men of different age groups suffering from mild to severe erectile dysfunction (ED). AIM To increase insight in the mechanisms of some key indicators of sexual quality of life in different age groups. METHODS The study sample consisted of 904 men with mild to severe ED. Mean age was 60.7 years (standard deviation [SD] = 12.4) and mean erectile function (EF) (International Index of Erectile Function [IIEF]) score was 14.5 (SD = 8.9). Multivariate analyses of variance were conducted to test the differences in outcomes among two age groups (65 <or= age > 65) and two levels of ED (16 <or= EF > 16). MAIN OUTCOME MEASURES We analyzed age, severity of ED, and interrelated indicators of sexual quality of life as worry about sexual or relationship functioning, sexual desire, and overall sexual satisfaction. Beyond, we aimed to see on which of these measures their interaction had specific independent effects. RESULTS Younger men at a higher level of ED reported higher levels of worry about sexual and relationship functioning than older men with high ED. Older men reported slightly less sexual desire than younger men; also, more ED was associated with lower sexual desire. Finally, men with less severe ED reported higher sexual satisfaction than men with more severe ED, whereas at all levels of ED severity, older men reported more sexual satisfaction than younger men. CONCLUSIONS Indicators of sexual quality of life among men with ED are poorer in those with more severe ED. However, younger men with severe ED worries concerning sexual functioning were more pronounced than among their older counterparts. Independent of the degree of severity of ED, older men indicated lower sexual desire but higher overall sexual satisfaction. Observed age-group differences were very small, however.
Analysis of the determinants of consumers' m-commerce usage activities

Purpose – The purpose of this paper is to examine the factors examining the determinants of users' mobile commerce (m‐commerce) usage activities.Design/methodology/approach – Data were collected from 402 users in Malaysia, and structural equation modelling analysis was employed to test the research model.Findings – The results showed that different demographic, motivation and security perceptions variables have different relationships with the types of m‐commerce usage activities.Practical implications – The results from this study will be useful for m‐commerce companies in formulating appropriate marketing strategies, as well as developing appropriate applications that will attract more consumers.Originality/value – Although past literatures have focused on technological aspects of m‐commerce, few studies have examined the applications and strategies of m‐commerce. Furthermore, most studies on m‐commerce adoptions have focused on the relationships between technology adoption factors and behavioural inten.
Incidence of reading disability in a population-based birth cohort, 1976-1982, Rochester, Minn.

OBJECTIVE To report the incidence of reading disability among school-aged children. SUBJECTS AND METHODS In this population-based, retrospective birth cohort study, subjects included all 5718 children born between 1976 and 1982 who remained in Rochester, Minn, after the age of 5 years. Based on records from all public and nonpublic schools, medical facilities, and private tutorial services and on results of all individually administered IQ and achievement tests, extensive medical, educational, and socioeconomic information were abstracted. Reading disability was established with use of research criteria based on 4 formulas (2 regression-based discrepancy, 1 non-regression-based discrepancy, and 1 low achievement). RESULTS Cumulative incidence rates of reading disability varied from 5.3% to 11.8% depending on the formula used. Boys were 2 to 3 times more likely to be affected than girls, regardless of the identification methods applied. CONCLUSIONS In this population-based birth cohort, reading disability was common among school-aged children and significantly more frequent among boys than girls, regardless of definition.
The Carriage of Pro‐Inflammatory Cytokine Gene Polymorphisms in Recurrent Pregnancy Loss

PROBLEM: Recurrent pregnancy loss (RPL) affects 2–4% of couples, and remains largely unexplained. Recent studies have examined the role of cytokines in the maintenance of normal pregnancy, which is linked with an increased expression of Th2 cytokines. Overexpression of Th1 cytokines is associated with RPL. Knowing that functional polymorphisms exist for certain cytokines, it has therefore been suggested that women with RPL may have a genetic predisposition to overexpress Th1 cytokines. METHOD OF STUDY: The genes for interleukin‐1 beta (IL‐1β) and tumor necrosis factor alpha (TNF‐α) carry functional gene polymorphisms. In both cases these are biallelic polymorphisms that can be detected by polymerase chain reaction followed by restriction fragment length polymorphism. The aim of this pilot study was to assess whether carriage of the rarer alleles (TNF*2 and IL‐1B*2) could act as independent risk factors in recurrent miscarriage. RESULTS: We found an increased incidence in the carriage of TNF*2, more pronounced in those women with two or more miscarriages. Carriage of the IL‐1B*2 either alone or in association with TNF*2 was not associated with recurrent miscarriage. CONCLUSION: There may be a role for these cytokine gene polymorphisms in RPL.
Structural Basis of the Toxicity of Chemicals in Cultured Human HeLa Cells

A coherent structure-activity relationship (SAR) model was derived from data based on the toxicity of chemicals in cultured human HeLa cells. The ability to construct such a model indicates that toxicity is a function of a finite number of mechanisms. A comparison of the HeLa SAR model with models that describe other toxicological phenomena demonstrated significant mechanistic similarities with systemic toxicity in rodents and ocular irritation in rabbits. Overall, the present analyses support the hypothesis that the inclusion of a battery of cell toxicity assays together with toxicokinetic models will result in a more predictive model of systemic toxicity in humans.
Extensive Manipulation of Caseicins A and B Highlights the Tolerance of These Antimicrobial Peptides to Change

ABSTRACT Caseicins A and B are low-molecular-weight antimicrobial peptides which are released by proteolytic digestion of sodium caseinate. Caseicin A (IKHQGLPQE) is a nine-amino-acid cationic peptide, and caseicin B (VLNENLLR) is a neutral eight-amino-acid peptide; both have previously been shown to exhibit antibacterial activity against a number of pathogens, including Cronobacter sakazakii. Previously, four variants of each caseicin which differed subtly from their natural counterparts were generated by peptide synthesis. Antimicrobial activity assays revealed that the importance of a number of the residues within the peptides was dependent on the strain being targeted. In this study, this engineering-based approach was expanded through the creation of a larger collection of 26 peptides which are altered in a variety of ways. The investigation highlights the generally greater tolerance of caseicin B to change, the fact that changes have a more detrimental impact on anti-Gram-negative activity, and the surprising number of variants which exhibit enhanced activity against Staphylococcus aureus.
Investigating FTIR based histopathology for the diagnosis of prostate cancer

Prostate cancer is the most common gender specific cancer. The current gold standard for diagnosis, histopathology, is subjective and limited by variation between different pathologists. The diagnostic problems associated with the correct grading and staging of prostate cancer (CaP) has led to an interest in the development of spectroscopic based diagnostic techniques. FTIR microspectroscopy used in combination with a Principal Component Discriminant Function Analysis (PC‐DFA) was applied to investigate FTIR based histopathology for the diagnosis of CaP. In this paper we report the results of a large patient study in which FTIR has been proven to grade CaP tissue specimens to a high degree of sensitivity and specificity. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
[Effect of Echinococcus multilocularis Cyst Fluid on the Expression of Five MAPK-pathway Genes of Rat Hepatic Stellate Cells].

OBJECTIVE To investigate the effect of Echinococcus multilocularis cyst fluid on five MAPK (mitogen-activated protein kinase)-pathway genes of rat hepatic stellate cell. METHODS Rat hepatic stellate cell line, HSC-T6 cells were co-cultured with different protein concentrations of E. multilocularis cyst fluid (0.01, 0.025, 0.05, 0.1, 0.2, 0.4, 0.9, 1.7, 3.4, 6.8, and 13.5 mg/ml) for 24 h. HSC-T6 cells cultured with complete medium served as control group. The morphological change of cells was observed under the microscope. The expression of extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK) and mitogen-activated protein kinase(p38) in HSC-T6 cells was detected by real time fluorescent quantitative PCR. RESULTS After co-cultured for 24 h, most HSC-T6 cells in 13.5 mg/ml group shrank as a precursor to slough off; In 6.8 mg/ml group, some HSC-T6 cells shrank and changed to long fusiform shape with many slender pseudopodia; In 3.4 mg/ml group, most HSC-T6 cells showed as adherent cells with an irregular polygon shape, formed a sheet with short pseudopodia. There was no difference in cell morphology between < 1.7 mg/ml groups and control group. When the protein concentration was above 1.7 mg/ml, the mRNA level of ERK1/2, JNK1/2, and P38 increased significantly increased. In 6.8 mg/ml cyst fluid group, the mRNA level of ERK1/2, JNK1/2, and P38 was higher than that of the control (P < 0.05). CONCLUSION 6.8 mg/ml Echinococcus multilocularis cyst fluid can have a significant impact on mRNA levels of ERK1/2, JNK1/2 and p38 in rat hepatic stellate cells.
The next ten stories on antiviral drug discovery (part E): advents, advances, and adventures.

This review article presents the fifth part (part E) in the series of stories on antiviral drug discovery. The ten stories belonging to this fifth part are dealing with (i) aurintricarboxylic acid; (ii) alkenyldiarylmethanes; (iii) human immunodeficiency virus (HIV) integrase inhibitors; (iv) lens epithelium-derived growth factor as a potential target for HIV proviral DNA integration; (v) the status presens of neuraminidase inhibitors NAIs in the control of influenza virus infections; (vi) the status presens on respiratory syncytial virus inhibitors; (vii) tricyclic (1,N-2-ethenoguanine)-based acyclovir and ganciclovir derivatives; (viii) glycopeptide antibiotics as antivirals targeted at viral entry; (ix) the potential (off-label) use of cidofovir in the treatment of polyoma (JC and BK) virus infections; and (x) finally, thymidine phosphorylase as a target for both antiviral and anticancer agents. © 2009 Wiley Periodicals, Inc. Med Res Rev, 31, No. 1, 118–160, 2010
Distinct functional roles of homologous Cu+ efflux ATPases in Pseudomonas aeruginosa

In bacteria, most Cu+‐ATPases confer tolerance to Cu by driving cytoplasmic metal efflux. However, many bacterial genomes contain several genes coding for these enzymes suggesting alternative roles. Pseudomonas aeruginosa has two structurally similar Cu+‐ATPases, CopA1 and CopA2. Both proteins are essential for virulence. Expressed in response to high Cu, CopA1 maintains the cellular Cu quota and provides tolerance to this metal. CopA2 belongs to a subgroup of ATPases that are expressed in association with cytochrome oxidase subunits. Mutation of copA2 has no effect on Cu toxicity nor intracellular Cu levels; but it leads to higher H2O2 sensitivity and reduced cytochrome oxidase activity. Mutation of both genes does not exacerbate the phenotypes produced by single‐gene mutations. CopA1 does not complement the copA2 mutant strain and vice versa, even when promoter regions are exchanged. CopA1 but not CopA2 complements an Escherichia coli strain lacking the endogenous CopA. Nevertheless, transport assays show that both enzymes catalyse cytoplasmic Cu+ efflux into the periplasm, albeit CopA2 at a significantly lower rate. We hypothesize that their distinct cellular functions could be based on the intrinsic differences in transport kinetic or the likely requirement of periplasmic partner Cu‐chaperone proteins specific for each Cu+‐ATPase.
Surface Layer Dynamics During E-Beam Treatment

The interaction of a pulsed intense electron beam with a metal target leads to rapid heating and subsequent cooling of the surface layer, accompanied by a series of phase transitions among the solid, liquid, vapor, and plasma phase. As a consequence of the treatment, depending on the beam parameters, the metal target is eroded and a topographical pattern (waviness, craters, etc.,) evolves on its surface. Surface roughening, a major drawback of pulsed intense electron beam treatment, is well known but lacks comprehensive understanding. In this paper, the process of pulsed intense electron beam interaction with metal targets is studied with special attention to the dynamics of the target surface layer and the development of surface roughness. The pulsed electron beam facility GESA generates electron beams with power density 0.5-2 MW/cm2, electron energy up to 120 keV, and pulse duration up to 200 μs. Different fast in situ diagnostics are applied to study the various processes occurring at the target surface: 1) melting and resolidification are visualized by time and space resolved imaging of the surface specular reflectivity; 2) spectroscopy is used to characterize the plasma phase adjacent to the target surface; 3) the evolution of irregularities and bubbles at the surface is studied by high-resolution microscopy; and 4) a stroboscopic imaging technique is applied to catch the evolution of the surface topography. The experimental data are compared with numerical simulations of heat transfer. All results and processes involved in pulsed intense electron beam treatment are discussed with respect to the target surface layer dynamics.
Clinical , cardiopulmonary , hematological and serum biochemical effects of sevo ̄ urane and iso ̄ urane anesthesia in oxygen under spontaneous breathing in sheep

Effects of sevo ̄urane and iso ̄urane anesthesia in oxygen on clinical, cardiopulmonary, hematological, and serum biochemical ®ndings were compared in sheep breathing spontaneously undergoing minor surgical operations during shortterm (60±80 min) or long-term (3±4 h) anesthesia. All sheep were premedicated with atropine sulfate (0.1 mg/kg) intramuscularly, and 10 min later, induced to anesthesia by intravenous infusion of sodium thiopental (mean 14.1 3.4 S.D. mg/kg). After intubation, they were anesthetized with either iso ̄urane or sevo ̄urane in oxygen at a total gas ̄ow rate of 1.5 l/ min. The results revealed that recovery time with sevo ̄urane was more rapid than with iso ̄urane. Respiration rates, tidal volume, minute ventilation and heart rates during sevo ̄urane anesthesia were similar to those during iso ̄urane anesthesia. The degree of respiratory acidosis during sevo ̄urane anesthesia was also similar to that during iso ̄urane anesthesia. There were no signi®cant differences between sevo ̄urane and iso ̄urane anesthesia in hematological and serum biochemical values. # 2000 Elsevier Science B.V. All rights reserved.
Crosslinguistic Intelligibility of Russian and German Speech in Noisy Environment

This paper discusses the results of the pilot experimental research dedicated to speech recognition and perception of the semantic content of the utterances in noisy environment. The experiment included perceptual-auditory analysis of words and phrases in Russian and German (in comparison) in the same noisy environment: various (pink and white) types of noise with various levels of signal-to-noise ratio. The statistical analysis showed that intelligibility and perception of the speech in noisy environment are influenced not only by noise type and its signal-to-noise ratio, but also by some linguistic and extralinguistic factors, such as the existing redundancy of a particular language at various levels of linguistic structure, changes in the acoustic characteristics of the speaker while switching from one language to another one, the level of speaker and listener’s proficiency in a specific language, and acoustic characteristics of the speaker’s voice.
Empathy or Antipathy? The Consequences of Racially and Socially Diverse Peers on Attitudes and Behaviors

Mixing across ethnic and class lines could potentially either spur understanding or inflame tensions between groups. We find that white students at a large state university randomly assigned AfricanAmerican roommates are more likely to endorse affirmative action policies 1_- 3_ years after college entry. Whites randomly assigned minority roommates are more likely to say they have more personal contact with and interact more comfortably with members of minority groups, and they are just as likely to remain close friends with their roommates beyond their initial year. Students become less supportive of higher taxes for the wealthy when they are assigned roommates from high-income families, and they appear to be more likely to volunteer when assigned roommates from low-income families. Taken together, these results suggest that students become more empathetic with the social groups to which their roommates belong.
Investigation of Tribological Behaviour of Nitrided and Coated AISI 4140 Steel

In the present study, samples made of AISI 4140 steel, pre-treated with plasma nitriding (PN) and coated with coatings like Titanium Nitride (TiN), Titanium Carbo Nitride (TiCN), Chromium Nitride (CrN), Aluminium Titanium Nitride (AlTiN) using Physical Vapour Deposition (PVD) technique, were investigated in terms of their dry and wet sliding wear behaviour. Wear tests, were performed with a pin-on-disc machine. The results of the duplex treated samples were compared with the conventional hard chrome coated AISI 4140 steel. The results showed improved wear properties of the duplex-treated specimens compared to the hard chrome coated AISI 4140 steel. TiCN coated and nitrided 4140 steel has shown the best performance among the investigated materials. Furthermore, the compound layer formed during nitriding was found to act as an intermediate hard layer leading to superior sliding wear properties. The improved performance of the duplex treated samples can be attributed to the presence of a nitrided subsurface. ARTICLE HISTORY Received 24-05-2017 Revised 27-06-2017 Accepted 04-07-2017 Published 27-07-2017
Big Data Analytics study «Third Wave»

In this study EMC Academic Alliance for the first time has applied the new approach to organize the Big Data Analytics study. The Multicenter Study "Third Wave" was presented at the EMC Academic Forum Russia & CIS 2015, at the International Scientific Congress "Globalistics-2015" and at the Russia National Supercomputing Forum 2015. Was implemented the variant of morphological analysis of Text Big Data from the Internet. The Study "Third Wave" is provided by Bill Schmarzo's 6 Steps Approach. Countries are set into positive or negative image's groups, and also into two groups with indication to technological order. The study can be developed to elaborate a new index for countries' rating. Big Data Analytics Study "Third Wave" relates to the new sphere for investigation - determination of Global management metrics.
Exercise training guidelines for the elderly.

UNLABELLED The capacity of older men and women to adapt to increased levels of physical activity is preserved, even in the most elderly. Aerobic exercise results in improvements in functional capacity and reduced risk of developing Type II diabetes in the elderly. High-intensity resistance training (above 60% of the one repetition maximum) has been demonstrated to cause large increases in strength in the elderly. In addition, resistance training result in significant increases in muscle size in elderly men and women. Resistance training has also been shown to significantly increase energy requirements and insulin action of the elderly. PURPOSE We have recently demonstrated that resistance training has a positive effect on multiple risk factors for osteoporotic fracture in previously sedentary postmenopausal women. METHODS Because the sedentary lifestyle of a long-term care facility may exacerbate losses of muscle function, we have applied this same training program to frail, institutionalized elderly men and women. RESULTS In a population of 100 nursing home residents, a randomly assigned high-intensity strength-training program resulted in significant gains in strength and functional status. In addition, spontaneous activity, measured by activity monitors, increased significantly in those participating in the exercise program whereas there was no change in the sedentary control group. Before the strength training intervention, the relationship of whole body potassium and leg strength was seen to be relatively weak (r2 = 0.29, P < 0.001), indicating that in the very old, muscle mass is an important but not the only determining factor of functional status. CONCLUSIONS Thus, exercise may minimize or reverse the syndrome of physical frailty, which is so prevalent among the most elderly. Because of their low functional status and high incidence of chronic disease, there is no segment of the population that can benefit more from exercise than the elderly.
Effects of heat and social stressors and within-pen weight variation on young pig performance and agonistic behavior.

A total of 486 crossbred weanling pigs was used in a series of experiments to determine first the effects of heat and social stress and their interaction on pig performance and, second, to determine a possible cause for the observed effects. Pigs were held six/nursery pen and fed and watered ad libitum. In Exp. 1, pigs were held at either thermal neutral 26.6 C for the 21 d and 23.8 C for the final 7 d, or at the heat-stress temperature (32.2 C) for the entire 28-d period. Within each temperature treatment, one-half of the pigs were left as single-litter controls and one-half were randomly regrouped (social stress). Pig feed intake and weight gain were reduced (P less than .05) among heat-stress pigs during the 7- to 28-d and 0- to 28-d periods. The interaction between social and thermal stress was significant for gain:feed ratio for the 7- to 28- and 0- to 28-d periods. Regrouping depressed gain:feed ratio only among heat-stressed pigs. In Exp. 2, a two-pig behavioral bioassay was used to determine if agonistic behaviors were influenced by heat stress. Pigs that were regrouped into 32.2 C rooms exhibited reduced mean level (P less than .05) and variation (P less than .001) of submissive behavior. Duration of aggressive behavior and latency to attack were unaffected by thermal treatments. Increased social stress at the time of regrouping could not account for poor performance of heat-stressed, regrouped pigs. (ABSTRACT TRUNCATED AT 250 WORDS)