Miracle-dz/UniFAR-FTUs huggingface dataset:
Value of stereo-electroencephalogram in reoperation of patients with pharmacoresistant epilepsy: a single center, retrospective study

Abstract Purpose: To systematically elucidate the value of stereo-electroencephalogram (SEEG) in the reoperation of patients with pharmacoresistant epilepsy. Methods: Epilepsy patients who had previously undergone a failed operation and agreed to a reoperation were included in this study. The single center retrospective study evaluated the value of SEEG in epileptogenic zones (EZ) lateralization and localization as well as the complications related to the implantation. Results: In total, fourteen patients met the inclusion criteria and received reoperation after implantation of SEEG. The average number of electrodes in each patient is 7.9. At the last available follow-up, nine (64.3%) patients were completely seizure-free according to the International League Against Epilepsy (ILAE) criteria. No significant complications were found in the cohort, two patients’ electrodes were loosened and removed because of the seizure. No significant predictors of seizure-free status were identified in the present study, including the result of presurgical MRI, pathology and surgical strategy. Conclusions: Based on the comprehensive presurgical assessment data and careful discussion of multidisciplinary team, failed epileptic surgery deserves a second chance. Moreover, SEEG is an effective and safe methodology to determine the location of the EZ with the goal of performing reoperation.
Rhinogenic Headache: Standardization of Terminologies Used for Headaches Arising From Problems in the Nose and Nasal Cavity

Objective: The use of different expressions between physicians frequently results in confusion in the process of diagnosis and treatment of patients with headaches due to problems in the nose and nasal cavity. The aim of this study was to assess the terminologies that have been used most frequently to standardize these terminologies. Methods: Terminologies that are most frequently used in general, including rhinogenic migraine, sinus headache, rhinogenic contact point headache, middle turbinate headache syndrome, and rhinogenic headache, were found by searching PubMed, Web of Science, and Google Scholar. These terminologies were objectively assessed on the basis of existing research and definitions and the range of diagnoses by organizations with public credibility. Results: There were many terminologies in use for headache related to nose; however, these were not logical expressions and only partly explained the phenomenon. Among the terms, “rhinogenic headache” was most appropriate in expressing and describing the related symptoms. Conclusion: The results indicated that the term “rhinogenic headache” is most appropriate for describing pain in the nose and eyes in patients with deformation within the nose or the nasal cavity due to external injuries or underlying diseases related to nose as observed on computed tomography.
Social capital predicts corruption risk in towns

Corruption is a social plague: gains accrue to small groups, while its costs are borne by everyone. Significant variation in its level between and within countries suggests a relationship between social structure and the prevalence of corruption, yet, large-scale empirical studies thereof have been missing due to lack of data. In this paper, we relate the structural characteristics of social capital of settlements with corruption in their local governments. Using datasets from Hungary, we quantify corruption risk by suppressed competition and lack of transparency in the settlement’s awarded public contracts. We characterize social capital using social network data from a popular online platform. Controlling for social, economic and political factors, we find that settlements with fragmented social networks, indicating an excess of bonding social capital has higher corruption risk, and settlements with more diverse external connectivity, suggesting a surplus of bridging social capital is less exposed to corruption. We interpret fragmentation as fostering in-group favouritism and conformity, which increase corruption, while diversity facilitates impartiality in public life and stifles corruption.
Allyl methyl sulfide, a garlic active component mitigates hyperglycemia by restoration of circulatory antioxidant status and attenuating glycoprotein components in streptozotocin-induced experimental rats

Abstract Diabetes is a major noncommunicable life-threatening chronic and pervasive condition that is consuming the world health in a petrifying rate. The circulatory system is one of the major sources of hyperglycemia-induced ROS generation. Historically, garlic has been revered as part of a healthful diet. Organosulfur compounds have been attributed to the medicinal properties and health benefits of garlic. The present study focuses on the ameliorative role of allyl methyl sulfide (AMS) in combating diabetic complications in diabetic rats. Male Wistar rats were randomly divided into four groups. Experimental diabetes was induced by a single intraperitoneal injection (i.p), of streptozotocin (STZ) (40 mg/kg b.w). STZ treated diabetic rats showed significant augment in plasma glucose level, lipidperoxidative (LPO) markers, glycoprotein components (hexose, hexosamine, sialic acid, and fucose), and significant decline in plasma insulin level, nonenzymatic antioxidants and activities of antioxidant enzymes in the circulatory system and tissues. Further, periodic acid-Schiff (PAS) staining of hepatic and renal tissues revealed positive stain accumulation and Western blot investigation of glucose transporter 2 (GLUT 2) in pancreas of STZ-induced hyperglycemic rats. Dietary intervention with AMS (100 mg/kg b.w) for 30 days demonstrated significant protective effects on all the biochemical parameters studied. Besides, biochemical findings were corroborated by histological exertion and Western blot study. The findings of current investigations recommended that AMS can ameliorate the consequences of diabetes due to their antioxidant efficacy and can be used as a potential therapeutic approach. Further studies are warranted to explore the clinical application of AMS.
Melatonin protects against paraquat‐induced damage during in vitro maturation of bovine oocytes

Paraquat (PQ), a broad‐spectrum agricultural pesticide, causes cellular toxicity by increasing oxidative stress levels in various biological systems, including the reproductive system. PQ exposure causes embryotoxicity and reduces the developmental abilities of embryos. However, there is little information regarding the toxic effects of PQ on oocyte maturation. In this study, we studied the toxic effects of PQ exposure and the effects of melatonin on PQ‐induced damage in bovine oocytes. PQ exposure disrupted nuclear and cytoplasmic maturation, which was manifested as decreased cumulus cell expansion, reduced first polar body extrusion, and abnormal distribution patterns of cortical granules and mitochondria. In addition, PQ treatment severely disrupted the ability of the resulted in vitro‐produced embryos to develop to the blastocyst stage. Moreover, PQ exposure significantly increased the intracellular reactive oxygen species (ROS) level and early apoptotic rate, and decreased the glutathione (GSH) level, antioxidative CAT and GPx4 mRNA, and apoptotic‐related Bcl-2/Bax mRNA ratio. These results indicated that PQ causes reproductive toxicity in bovine oocytes. Melatonin application resulted in significant protection against the toxic effects of PQ in PQ‐exposed oocytes. The mechanisms underlying the role of melatonin included the inhibition of PQ‐induced p38 mitogen‐activated protein kinase (MAPK) activation, and restoration of abnormal trimethyl‐histone H3 lysine 4 (H3K4me3) and trimethyl‐histone H3 lysine 9 (H3K9me3) levels. These results reveal that melatonin serves as a powerful agent against experimental PQ‐induced toxicity during bovine oocyte maturation and could form a basis for further studies to develop therapeutic strategies against PQ poisoning.
A Formal Model of Fuzzy-Trace Theory: Variations on Framing Effects and the Allais Paradox

Fuzzy-trace theory assumes that decision-makers process qualitative “gist” representations and quantitative “verbatim” representations in parallel. We develop a lattice model of fuzzy-trace theory that explains both processes. Specifically, the model provides a novel formalization of how (a) decision-makers encode multiple representations of options in parallel, (b) representations compete or combine so that choices often turn on the simplest representation of encoded gists, and (c) choices between representations are made based on positive versus negative valences associated with social and moral principles stored in long-term memory (e.g., saving lives is good). The model integrates effects of individual differences in numeracy, metacognitive monitoring and editing, and sensation seeking. We conducted a systematic review of variations on framing effects and the Allais Paradox, both core phenomena of risky decision-making, and tested whether our model could predict observed choices: The model successfully predicted 82 of 88 (93%) pairs of studies (comparing gain to loss conditions) demonstrating 16 variations on effects, theoretically critical manipulations that eliminate or exaggerate framing effects. When examining these conditions individually, the model successfully predicted 153 (90%) of 170 eligible studies. Parameters of the model varied in theoretically meaningful ways with differences in numeracy, metacognitive monitoring, and sensation seeking, accounting for risk preferences at the group level. New experiments show similar results at the individual level. The model is also shown to be scientifically parsimonious using standard measures. Relations to current theories, such as Cumulative Prospect Theory, and potential extensions are discussed.
Animal models of multiple sclerosis: From rodents to zebrafish

Multiple sclerosis (MS) is a chronic, immune-mediated demyelinating disease of the central nervous system. Animal models of MS have been critical for elucidating MS pathological mechanisms and how they may be targeted for therapeutic intervention. Here we review the most commonly used animal models of MS. Although these animal models cannot fully replicate the MS disease course, a number of models have been developed to recapitulate certain stages. Experimental autoimmune encephalomyelitis (EAE) has been used to explore neuroinflammatory mechanisms and toxin-induced demyelinating models to further our understanding of oligodendrocyte biology, demyelination and remyelination. Zebrafish models of MS are emerging as a useful research tool to validate potential therapeutic candidates due to their rapid development and amenability to genetic manipulation.
How Should I Slice My Network?: A Multi-Service Empirical Evaluation of Resource Sharing Efficiency

By providing especially tailored instances of a virtual network,network slicing allows for a strong specialization of the offered services on the same shared infrastructure. Network slicing has profound implications on resource management, as it entails an inherent trade-off between: (i) the need for fully dedicated resources to support service customization, and (ii) the dynamic resource sharing among services to increase resource efficiency and cost-effectiveness of the system. In this paper, we provide a first investigation of this trade-off via an empirical study of resource management efficiency in network slicing. Building on substantial measurement data collected in an operational mobile network (i) we quantify the efficiency gap introduced by non-reconfigurable allocation strategies of different kinds of resources, from radio access to the core of the network, and (ii) we quantify the advantages of their dynamic orchestration at different timescales. Our results provide insights on the achievable efficiency of network slicing architectures, their dimensioning, and their interplay with resource management algorithms.
Factors influencing ultra-endurance athletes food choices: an adapted food choice questionnaire

ABSTRACT Inadequate nutritional intake has been reported during ultra-endurance training and competition. While substandard nutritional knowledge may contribute to inappropriate nutritional choices, the relationship between these variables is often weak. As such, this study investigated the importance of a range of factors to the food choices of ultra-endurance athletes. An existing food choices questionnaire was extended to reflect the main factors proposed to influence the food choices of these athletes. The questionnaire was pilot tested with endurance athletes, during which, it was refined and reassessed for internal consistency and test-retest reliability. Subsequently, 101 experienced ultra-endurance athletes completed the amended questionnaire. Athletes also documented dietary restrictions or strategies employed in preparation for competition. The factors rated as important by the majority of the athletes were “provides me with energy”, “do not cause me gastrointestinal discomfort” and, “are nutritious”. Despite the high importance of the provision of energy, only 38.2% of participants reported following a high carbohydrate diet in preparation for competition. In addition, given that nutritious foods are typically high in fibre, it is likely that this factor may conflict with the avoidance of gastrointestinal discomfort. The potential incompatibility of these factors may help explain the observed suboptimal nutritional intake.
Mild Hypogammaglobulinemia Can Be a Serious Condition

Background: Most patients with primary antibody deficiency (PAD) suffer from less well-described and understood forms of hypogammaglobulinemia (unclassified primary antibody deficiency, unPAD). Because of the moderately decreased immunoglobulin levels compared to CVID, unPAD is generally considered to be clinically mild and not very relevant. Objective: To describe our cohort of—mainly—unPAD patients, and to analyze whether subgroups can be identified. Methods: Data were prospectively collected (February-2012 to June-2016) as part of a standardized, 1-day Care Pathway for suspected primary immunodeficiency. The TNO-AZL Questionnaire for Health-Related Quality of Life (HRQoL) was part of the pre-first-visit intake procedure. Results: Three hundred and twenty patients were referred to the Care Pathway. Data from 23/27 children and 99/113 adults who were diagnosed with PAD and gave informed consent were available for analysis. 89/99 adults had unPAD, the majority (74%) were female and 44% already showed bronchiectasis. HRQoL was significantly decreased in all domains, meaning that a lot of unPAD patients had to cope simultaneously with pain, negative feelings and impairments in cognition, home management tasks, sleep, social interaction, and work. The most prominently impaired HRQoL domain was vitality, indicating these patients feel extremely tired and worn out. Conclusion: These results highlight the need for more attention to the potential patient burden of unPADs. A larger cohort is needed to increase our understanding of unPADs and to analyze whether distinct subgroups can be identified. For now, it is important for the clinician to acknowledge the existence of unPAD and be aware of its potential consequences, in order to timely and appropriately manage its effects and complications.
Low-Complexity Detection of M-ary PSK Faster-than-Nyquist Signaling

Faster-than-Nyquist (FTN) signaling is a promising non-orthogonal physical layer transmission technique to improve the spectral efficiency of future communication systems but at the expense of intersymbol-interference (ISI). In this paper, we investigate the detection problem of FTN signaling and formulate the sequence estimation problem of any M-ary phase shift keying (PSK) FTN signaling as an optimization problem that turns out to be non-convex and nondeterministic polynomial time (NP)-hard to solve. We propose a novel algorithm, based on concepts from semidefinite relaxation (SDR) and Gaussian randomization, to detect any M-ary PSK FTN signaling in polynomial time complexity regardless of the constellation size M or the ISI length. Simulation results show that the proposed algorithm strikes a balance between the achieved performance and the computational complexity. Additionally, results show the merits of the proposed algorithm in improving the spectral efficiency when compared to Nyquist signaling and the state-of-the-art schemes from the literature. In particular, when compared to Nyquist signaling at the same error rate and signal-to-noise ratio, our scheme provides around 17% increase in the spectral efficiency at a roll-off factor of 0.3.
Downregulation of microRNA-4295 enhances cisplatin-induced gastric cancer cell apoptosis through the EGFR/PI3K/Akt signaling pathway by targeting LRIG1

Gastric cancer (GC) is one of the leading causes of cancer-associated mortality worldwide. The aim of the present study was to investigate the mechanism of microRNA-4295 (miR-4295), which regulates cisplatin (DDP)-induced apoptosis in GC cells through the leucinerich repeats and immunoglobulin-like domains 1 (LRIG1)-mediated epidermal growth factor receptor (EGFR)/phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway. Two cell lines were selected, one with the highest expression of miR-4295 and one with the lowest expression of LRIG1, for the experiments. The half maximal inhibitory concentration of DDP in the human GC MKN-28 and MKN-45 cell lines was calculated, and mitochondrial membrane potentials of the GC cells were detected by tetramethylrhodamine, ethyl ester, perchlorate staining. The proliferation and apoptosis of GC cells with or without DDP treatment were assessed by MTT assay and plate colony formation, as well as flow cytometry and TUNEL staining. Western blot analysis and reverse transcription-quantitative polymerase chain reaction were employed to determine the expression of EGFR/PI3K/Akt signaling pathway-related genes and apoptosis-related genes. LRIG1 was identified as a target gene of miR-4295. The expression of miR-4295 was upregulated, and the expression of LRIG1 was downregulated in GC cells. Furthermore, DDP enhanced the decrease in miR-4295 expression and the increase in LRIG1 expression in GC cells. miR-4295 promoted the proliferation and inhibited the DDP-induced apoptosis of GC cells without DDP treatment. In addition, miR-4295 increased the expression levels of EGFR, PI3K, Akt, p-PI3K and p-Akt, suggesting that miR-4295 promotes the activation of the EGFR/PI3K/Akt signaling pathway by targeting LRIG1. miR-4295 targeted and negatively regulated LRIG1 expression to activate the EGFR/PI3K/Akt signaling pathway, thereby promoting the proliferation of the GC cells and inhibiting the apoptosis of the GC cells induced by DDP. Therefore, miR-4295 may be a novel therapeutic target in patients with GC.
The feasibility of an automatic prompting system in assisting people with traumatic brain injury in cooking tasks

Abstract Purpose: Individuals with traumatic brain injury (TBI) often experience difficulties in performing kitchen-related sequencing tasks due to cognitive deficits. The primary aim of this study is to examine the feasibility of a context-aware automatic prompting system in assisting individuals with TBI in multi-step cooking tasks. Method: Sixteen individuals with TBI participated in the study. A randomized cross-over design was used to compare the automatic prompting method with a conventional user-controlled method through a tablet device. Participant performance under each prompting method was assessed using the Performance Assessment of Self-Care Skills in terms of independence, safety, and adequacy. Subjective workload and qualitative feedback were also collected. Results: The automatic method, when compared with the user-controlled method, significantly decreased the amount of external assistance required by participants, received higher ratings in user perceived ease-of-use, and was considered less stressful for participants. However, the user-controlled method showed strengths in offering participants more flexibility in terms of controlling on the timing of prompts. Conclusions: The results provided insight into the potential benefits and user perceptions of a context-aware prompting system. The information could contribute to the future development of advanced prompting technology for people with cognitive impairments in completing sequential tasks. Implications for Rehabilitation For people with traumatic brain injury, the context-aware prompting method showed advantages in improving user performance, receiving better ratings on ease-of-use, and decreasing stress levels, compared to the user-controlled prompting method in completing multi-step cooking tasks. Future prompting systems for people with cognitive impairments may allow users to control the pace of prompting and use sensing information as back-up assistance in critical situations. In this way, the system may help users monitor their actions and offer confirmations, especially at steps with safety concerns, thus enhancing the sense of security and reducing the stress from self-monitoring.
The Chlamydia M278 Major Outer Membrane Peptide Encapsulated in the Poly(lactic acid)-Poly(ethylene glycol) Nanoparticulate Self-Adjuvanting Delivery System Protects Mice Against a Chlamydia muridarum Genital Tract Challenge by Stimulating Robust Systemic and Local Mucosal Immune Responses

Recently, we reported that our PPM chlamydial nanovaccine [a biodegradable co-polymeric PLA-PEG (poly(lactic acid)-poly(ethylene glycol))-encapsulated M278 peptide (derived from the major outer membrane protein (MOMP) of Chlamydia)] exploits the caveolin-mediated endocytosis pathway for endosomal processing and MHC class II presentation to immune-potentiate Chlamydia-specific CD4+ T-cell immune effector responses. In the present study, we employed the Chlamydia muridarum mouse infection model to evaluate the protective efficacy of PPM against a genital tract challenge. Our results show that mice immunized with PPM were significantly protected against a homologous genital tract challenge evidently by reduced vaginal bacterial loads. Protection of mice correlated with enhanced Chlamydia-specific adaptive immune responses predominated by IFN-γ along with CD4+ T-cells proliferation and their differentiation to CD4+ memory (CD44high CD62Lhigh) and effector (CD44high CD62Llow) T-cell phenotypes. We observed the elevation of M278- and MOMP-specific serum antibodies with high avidity in the ascending order IgG1 > IgG2b > IgG2a. A key finding was the elevated mucosal IgG1 and IgA antibody titers followed by an increase in MOMP-specific IgA after the challenge. The Th1/Th2 antibody titer ratios (IgG2a/IgG1 and IgG2b/IgG1) revealed that PPM evoked a Th2-directed response, which skewed to a Th1-dominated antibody response after the bacterial challenge of mice. In addition, PPM immune sera neutralized the infectivity of C. muridarum in McCoy cells, suggesting the triggering of functional neutralizing antibodies. Herein, we reveal for the first time that subcutaneous immunization with the self-adjuvanting biodegradable co-polymeric PPM nanovaccine immune-potentiated robust CD4+ T cell-mediated immune effector responses; a mixed Th1 and Th2 antibody response and local mucosal IgA to protect mice against a chlamydial genital tract challenge.