Miracle-dz/UniFAR-FTUs huggingface dataset:
Reporting quality of randomised controlled trial abstracts on age-related macular degeneration health care: a cross-sectional quantification of the adherence to CONSORT abstract reporting recommendations

Objective To assess the reporting quality of randomised controlled trial (RCT) abstracts on age-related macular degeneration (AMD) healthcare, to evaluate the adherence to the Consolidated Standards of Reporting Trials (CONSORT) statement’s recommendations on minimum abstract information and to identify journal characteristics associated with abstract reporting quality. Design Cross-sectional evaluation of RCT abstracts on AMD healthcare. Methods A PubMed search was implemented to identify RCT abstracts on AMD healthcare published in the English language between January 2004 and December 2013. Data extraction was performed by two parallel readers independently by means of a documentation format in accordance with the 16 items of the CONSORT checklist for abstracts. The total number of criteria fulfilled by an abstract was derived as primary endpoint of the investigation; incidence rate ratios (IRRs) with unadjusted 95% CI were estimated by means of multiple Poisson regression to identify journal and article characteristics (publication year, multicentre design, structured abstract recommendations, effective sample size, effective abstract word counts and journal impact factor) possibly associated with the total number of fulfilled items. Study characteristics 136 of 673 identified abstracts (published in 36 different journals) fulfilled all eligibility criteria. Results The median number of fulfilled items was 7 (95% CI 7 to 8). No abstract reported all 16 recommended items; the maximum total number was 14, the minimum 3 of 16 items. Multivariate analysis only demonstrated the abstracts’ word counts as being significantly associated with a better reporting of abstracts (Poisson regression-based IRR 1.002, 95% CI 1.001 to 1.003). Conclusions Reporting quality of RCT abstracts on AMD investigations showed a considerable potential for improvement to meet the CONSORT abstract reporting recommendations. Furthermore, word counts of abstracts were identified as significantly associated with the overall abstract reporting quality.
A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency

Tordo et al. present a novel AAV gene therapy vector, AAV-TT, which exceeds the current benchmark neurotropic serotypes AAV9 and AAVrh10 and enables unprecedented correction of a lysosomal transmembrane enzyme deficiency. AAV-TT based gene therapies may thus be suitable for the treatment of human neurological diseases characterised by global neuropathology.
RNA Editing and Retrotransposons in Neurology

Compared to sites in protein-coding sequences many more targets undergoing adenosine to inosine (A-to-I) RNA editing were discovered in non-coding regions of human cerebral transcripts, particularly in genetic transposable elements called retrotransposons. We review here the interaction mechanisms of RNA editing and retrotransposons and their impact on normal function and human neurological diseases. Exemplarily, A-to-I editing of retrotransposons embedded in protein-coding mRNAs can contribute to protein abundance and function via circular RNA formation, alternative splicing, and exonization or silencing of retrotransposons. Interactions leading to disease are not very well understood. We describe human diseases with involvement of the central nervous system including inborn errors of metabolism, neurodevelopmental disorders, neuroinflammatory and neurodegenerative and paroxysmal diseases, in which retrotransposons (Alu and/or L1 elements) appear to be causally involved in genetic rearrangements. Sole binding of single-stranded retrotransposon transcripts by RNA editing enzymes rather than enzymatic deamination may have a homeostatic effect on retrotransposon turnover. We also review evidence in support of the emerging pathophysiological function of A-to-I editing of retrotransposons in inflammation and its implication for different neurological diseases including amyotrophic lateral sclerosis, frontotemporal dementia, Alzheimer's and Parkinson's disease, and epilepsy.
PREDICTIVE FACTORS FOR PROLIFERATIVE VITREORETINOPATHY FORMATION AFTER UNCOMPLICATED PRIMARY RETINAL DETACHMENT REPAIR.

PURPOSE To determine predictive factors of proliferative vitreoretinopathy (PVR) formation after uncomplicated primary retinal detachment repair. METHODS Retrospective, single-center, case-control study of 74 consecutive patients with (37 eyes) and without (37 eyes) PVR formation after undergoing uncomplicated primary surgery for retinal detachment repair. Logistic regression was used to assess factors associated with PVR formation. RESULTS Retinal detachment involving the macula was 4.2 times (adjusted odds ratio; 95% confidence interval, 1.4-12.9; P = 0.0119) more likely to have PVR formation compared with those without. Patients who were current or former smokers were 3.6 times (adjusted odds ratio; 95% confidence interval, 1.1-11.7; P = 0.0352) more likely to have PVR formation compared with nonsmokers. Compared with 25-gauge (g) vitrectomy, larger gauge vitrectomy (20 g or 23 g) was 3.6 times (adjusted odds ratio; 95% confidence interval, 1.2-11.3; P = 0.0276) more likely to have PVR formation. Duration of retinal detachment symptoms, high myopia, lens status, lattice degeneration, location of retinal break, number of retinal breaks, and surgical technique (e.g., scleral buckle with or without vitrectomy versus vitrectomy alone) were not found to be predictive of PVR formation. CONCLUSION Cigarette smoking and macular involvement are significant risk factors predictive of PVR formation after uncomplicated primary retinal detachment repair.
Mediating role of managing information technology and its impact on firm performance: Insight from China

Purpose Managing IT with firm performance (FM) has always been a debatable topic in literature and practice. Prior studies examining the above relationship have reported mixed results and have yet ignored the eminent managing IT practices. The purpose of this paper is to empirically investigate the relevance of Val-IT 2.0 practice in managing IT investment, and its mediating role in the FM context. Design/methodology/approach This paper is developed on two themes of literature. First, managing IT as a firm’s IT capability in order to generate value from IT investment. Second, IT as a firm’s resource under resource-based view offers firm’s competence that deploys potentials in achieving FM. The structural equation modeling with partial least squares techniques used for analyzing data collected from 176 organization’s IT, and business executives in China. Findings The results of this study show empirical evidence that Val-IT’s components (value governance, portfolio management, and investment management) are significantly linked to the management of IT (MIT), and it found to be a significant mediator between Val-IT components and FM. Research limitations/implications This research contributes to the literature and practice by way of highlighting the value generation through managing IT on FM. Originality/value This study is fully based on Val-IT 2.0 with the FM where the managing IT mediate this relationship in a country-specific study in China. This study adds to the Chinese information system literature which suffers the lack of empirical studies in the context of MIT research.
A Theory on Urban Resilience to Floods—A Basis for Alternative Planning Practices

River cities require a management approach based on resilience to floods rather than on resistance. Resisting floods by means of levees, dams, and channelization neglects inherent uncertainties arising from human-nature couplings and fails to address the extreme events that are expected to increase with climate change, and is thereby not a reliable approach to long-term flood safety. By applying resilience theory to address system persistence through changes, I develop a theory on "urban resilience to floods" as an alternative framework for urban flood hazard management. Urban resilience to floods is defined as a city's capacity to tolerate flooding and to reorganize should physical damage and socioeconomic disruption occur, so as to prevent deaths and injuries and maintain current socioeconomic identity. It derives from living with periodic floods as learning opportunities to prepare the city for extreme ones. The theory of urban resilience to floods challenges the conventional wisdom that cities cannot live without flood control, which in effect erodes resilience. To operationalize the theory for planning practice, a surrogate measure—the percent floodable area—is developed for assessing urban resilience to floods. To enable natural floodplain functions to build urban resilience to floods, flood adaptation is advocated in order to replace flood control for mitigating flood hazards.
Dynamic Statistical Models for Pyroclastic Density Current Generation at Soufrière Hills Volcano

To mitigate volcanic hazards from pyroclastic density currents, volcanologists generate hazard maps that provide long-term forecasts of areas of potential impact. Several recent efforts in the field develop new statistical methods for application of flow models to generate fully probabilistic hazard maps that both account for, and quantify, uncertainty. However a limitation to the use of most statistical hazard models, and a key source of uncertainty within them, is the time-averaged nature of the datasets by which the volcanic activity is statistically characterized. Where the level, or directionality, of volcanic activity frequently changes, e.g. during protracted eruptive episodes, or at volcanoes that are classified as persistently active, it is not appropriate to make short term forecasts based on longer time-averaged metrics of the activity. Thus, here we build, fit and explore dynamic statistical models for the generation of pyroclastic density current from Soufriere Hills Volcano (SHV) on Montserrat including their respective collapse direction and flow volumes based on 1996-2008 flow datasets. The development of this approach allows for short-term behavioral changes to be taken into account in probabilistic volcanic hazard assessments. We show that collapses from the SHV lava dome follow a clear pattern, and that a series of smaller flows in a given direction often culminate in a larger collapse and thereafter directionality of the flows change. Such models enable short term forecasting (weeks to months) that can reflect evolving conditions such as dome and crater morphology changes and non-stationary eruptive behavior such as extrusion rate variations. For example, the probability of inundation of the Belham Valley in the first 180 days of a forecast period is about twice as high for lava domes facing Northwest toward that valley as it is for domes pointing East toward the Tar River Valley. As rich multi-parametric volcano monitoring dataset become increasingly available, eruption forecasting is becoming an increasingly viable and important research field. We demonstrate an approach to utilize such data in order to appropriately ‘tune’ probabilistic hazard assessments for pyroclastic flows. Our broader objective with development of this method is to help advance time-dependent volcanic hazard assessment, by bridging the
MAX-PolyMem: High-Bandwidth Polymorphic Parallel Memories for DFEs

Memory bandwidth is critical for many modern applications and architectures. Parallel memories should alleviate this problem, but they are difficult to design and implement for non-trivial access patterns. Our work addresses these challenges through PolyMem, a Polymorphic Parallel Memory which acts as a software cache and enables parallel memory accesses for different combinations of access patterns. PolyMem's design is based on the Polymorphic Register File (PRF) design, which guarantees conflict-free parallel access for memory access patterns widely used in scientific and multimedia applications. We present in detail the design and implementation of MAXPolyMem, the first native implementation of PolyMem using Maxeler's toolchain. Our design supports multiple lanes, multiple read ports, and concurrent read and write operations. We further provide a detailed empirical analysis of the performance of MAX-PolyMem, including two sets of results. First, we conduct a thorough design space exploration to determine the best configurations and/or the performance bounds of MAX-PolyMem. For example, the design with the maximum read bandwidth is a 512KB memory, with 4 read ports, running at 137MHz, which can reach a peak read bandwidth of around 32GB/s. Second, to determine whether the MAXPolyMem can reach and sustain these peaks, we implement the STREAM-Copy benchmark. The benchmarking results demonstrate that, in practice, MAX-PolyMem reaches over 99% of the theoretical peak performance.
Arbitrary-Oriented Ship Detection Framework in Optical Remote-Sensing Images

Ship detection is a challenging problem in complex optical remote-sensing images. In this letter, an effective ship detection framework in remote-sensing images based on the convolutional neural network is proposed. The framework is designed to predict bounding box of ship with orientation angle information. Note that the angle information which is added to bounding box regression makes bounding box accurately fit into the ship region. In order to make the model adaptable to the detection of multiscale ship targets, especially small-sized ships, we design the network with feature maps from the layers of different depths. The whole detection pipeline is a single network and achieves real-time detection for a $704 \times 704$ image with the use of Titan X GPU acceleration. Through experiments, we validate the effectiveness, robustness, and accuracy of the proposed ship detection framework in complex remote-sensing scenes.
Effects of rearing systems on reproductive hormones secretion and their receptors gene expression in Xianju chickens under summer conditions

ABSTRACT Previous study in our lab showed that indigenous Xianju chickens from free‐range system (FRS) under summer conditions had lower egg production than those from conventional cage rearing system (CRS). The objective of this study was to preliminarily determine the FRS‐dependent mechanism of depressing laying performance according to determining the effect of rearing systems on reproductive hormones secretion and their receptors mRNA expression in Xianju chickens reared under summer conditions. A total of 360 indigenous Xianju chickens were randomly allocated to CRS and FRS groups, each of which included 5 replicates of 36 hens. The experiment lasted between 21 and 29 wk of age. We found that the ovarian weight, numbers of small yellow follicles, and large white follicles in the FRS group were lower than those in the CRS group (P < 0.05). Changing from CRS to FRS increased serum concentrations of prolactin and decreased serum‐luteinizing hormone and progesterone levels (P < 0.05). Gene expressions in the preovulatory follicles from FRS hens were upregulated for prolactin receptor and downregulated for luteinizing hormone receptor and progesterone receptor, compared to those from CRS hens (P < 0.05). It can be concluded that changing from CRS to FRS in the current experimental conditions depressed egg production traits in Xianju chickens by inducing a synergistic activity of reproductive hormones and the gene expressions of their receptors.
Purinergic receptor stimulation induces calcium oscillations and smooth muscle contraction in small pulmonary veins

We investigated the excitation–contraction coupling mechanisms in small pulmonary veins (SPVs) in rat precision‐cut lung slices. We found that SPVs contract strongly and reversibly in response to extracellular ATP and other vasoconstrictors, including angiotensin‐II and endothelin‐1. ATP‐induced vasoconstriction in SPVs was associated with the stimulation of purinergic P2Y2 receptors in vascular smooth muscle cell, activation of phospholipase C‐β and the generation of intracellular Ca2+ oscillations mediated by cyclic Ca2+ release events via the inositol 1,4,5‐trisphosphate receptor. Active constriction of SPVs may play an important role in the development of pulmonary hypertension and pulmonary oedema.
Long-term rivaroxaban for the treatment of acute venous thromboembolism in patients with active cancer in a prospective multicenter trial

Background/Aims Limited data are available regarding the efficacy of rivaroxaban for the treatment of cancer-associated venous thromboembolism (VTE). The aim of this study was to evaluate the effectiveness and safety of rivaroxaban for the treatment of VTE in active cancer patients. Methods In this prospective, multicenter, open-label trial (NCT01989845), we enrolled patients with active cancer and objectively diagnosed lower-extremity deep vein thrombosis, pulmonary embolism (PE), or both from November 2013 to June 2016. Active cancer was defined as a histologically confirmed malignancy, which was diagnosed or treated within the previous 6 months, or as a recurrent/metastatic cancer. Patients received oral rivaroxaban 15 mg twice daily for first 3 weeks, followed by 20 mg once daily for 6 months. The primary outcome was the symptomatic recurrent VTE and the secondary outcomes included any recurrent VTE, major or clinically relevant non-major (CRNM) bleeding events, and overall mortality. All study outcomes were validated by blinded central adjudication. Results Of 124 patients enrolled, 110 (88.7%) had solid cancer, 93 (75.0%) had metastatic disease, and 110 (88.7%) were receiving chemotherapy or radiotherapy. During the 6-month study period, seven patients experienced symptomatic recurrent VTE (cumulative incidence, 5.9%), and two patients experienced incidental recurrent PE (cumulative incidence of any recurrent VTE, 7.6%). Major bleeding events occurred in six patients (cumulative incidence, 5.3%) and CRNM bleeding events in 11 patients (cumulative incidence, 10.2%). Twenty-eight patients (overall mortality, 24.0%) died. Conclusions Rivaroxaban is effective and safe for the treatment of VTE in patients with active cancer.
A subset of five human mitochondrial formyl peptides mimics bacterial peptides and functionally deactivates human neutrophils

BACKGROUND Trauma causes inflammation by releasing mitochondria that act as Danger-Associated Molecular Patterns (DAMPs). Trauma also increases susceptibility to infection. Human mitochondria contain 13 N-formyl peptides (mtFPs). We studied whether mtFPs released into plasma by clinical injury induce neutrophil (PMN) inflammatory responses, whether their potency reflects their similarity to bacterial FPs and how their presence at clinically relevant concentration affects PMN function. METHODS N-terminal sequences of the 13 mtFPs were synthesized. Changes in human PMN cytosolic Ca2+ concentration ([Ca2+]i) and chemotactic responses to mtFPs were studied. Sequence similarity of mtFPs to the canonical bacterial peptide f-Met-Leu-Phe (fMLF/fMLP) was studied using the BLOcks SUbstitution Matrix 62 (BLOSUM 62) system. The presence of mtFPs in plasma of trauma patients was assayed by Enzyme-linked immunosorbent assay (ELISA). The effects of the most potent mtFP (ND6) on PMN signaling and function were then studied at ambient clinical concentrations by serial exposure of native PMN to ND6, chemokines and leukotrienes. RESULTS Five mtFPs (ND6, ND3, ND4, ND5, and Cox 1) induced [Ca2+]i flux and chemotaxis in descending order of potency. Evolutionary similarity to fMLF predicted [Ca2+]i flux and chemotactic potency linearly (R2 = 0.97, R2 = 0.95). Chemoattractant potency was also linearly related to [Ca2+]i flux induction (R2 = 0.92). Active mtFPs appear to circulate in significant amounts immediately after trauma and persist through the first week. The most active mtFP, ND6, suppresses responses to physiologic alveolar chemoattractants (CXCL-1, leukotriene B4) as well as to fMLF where CXCL-1 and leukotriene B4 do not suppress N-formyl peptide receptor (FPR)-1 responses to mtFPs. Prior FPR-1 inhibition rescues PMN from heterologous suppression of CXCR-1 and BLT-1 by mtFPs. CONCLUSION The data suggest mtFPs released by injured tissue may attract PMN to trauma sites while suppressing PMN responses to other chemoattractants. Inhibition of mtFP-FPR1 interactions might increase PMN recruitment to lung bacterial inoculation after trauma. These findings suggest new paradigms for preventing infections after trauma. LEVEL OF EVIDENCE Therapeutic, Level IV.
Parallel Multilevel Cell STT-MRAMs for Optimized Area Energy and Read–Write Operations

Spin-transfer torque (STT) magnetic random access memory (MRAM) is considered as a promising candidate for the next generation embedded memory applications. The advent of a perpendicular magnetic anisotropy-based magnetic tunnel junction (PMTJ) device has made the STT-MRAM viable for low-power high-density on-chip memory architectures. However, intense research efforts are still required to optimize the single-level cell and multilevel cell (MLC) STT-MRAMs in terms of area, energy, and read–write operations at ultralow power supply voltages. In this paper, a parallel MLC (pMLC) STT-MRAM (20–50 nm) is proposed to provide smaller footprint area, energy efficient, and optimized read–write operations with very low failure probabilities at the supply voltage of 1 V. These designs utilize high- ${k}$ gate dielectric gate-all-around silicon nanowire-based vertical NMOS transistor as a switching device. The PMTJ device is modeled using Verilog-A. The HSPICE simulation results affirm the suitability of pMLC designs, e.g., 3-bit pMLC design exhibits, switching error probability much less than 10−9, and average write energy of <2 pJ with minimum cell-area at the pulsewidth of 10 ns.