Miracle-dz/UniFAR-FTUs huggingface dataset:
Long-chain n-3 fatty acids enhance neonatal insulin-regulated protein metabolism in piglets by differentially altering muscle lipid composition Published, JLR Papers in Press, August 2, 2007.

This study investigated the role of long-chain n-3 polyunsaturated fatty acids (LCn-3PUFAs) of muscle phospholipids in the regulation of neonatal metabolism. Twenty-eight piglets were weaned at 2 days of age and raised on one of two milk formulas that consisted of either a control formula supplying 0% or a formula containing 3.5% LCn-3PUFAs until 10 or 28 days of age. There was a developmental decline in the insulin sensitivity of amino acid disposal in control pigs during the first month of life, with a slope of −2.24 μmol·kg−1·h−1 (P = 0.01) per unit of insulin increment, as assessed using hyperinsulinemic-euglycemic-euaminoacidemic clamps. LCn-3PUFA feeding blunted this developmental decline, resulting in differing insulin sensitivities (P < 0.001). When protein metabolism was assessed under parenteral feeding-induced hyperinsulinemia, LCn-3PUFAs reduced by 16% whole body oxidative losses of amino acids (from 238 to 231 μmol·kg−1·h−1; P = 0.06), allowing 41% more amino acids to accrete into body proteins (from 90 to 127 μmol·kg−1·h−1; P = 0.06). The fractional synthetic rate of muscle mixed proteins remained unaltered by the LCn-3PUFA feeding. However, LCn-3PUFAs retarded a developmental increase in the essential-to-nonessential amino acid ratio of the muscle intracellular free pool (P = 0.05). Overall, alterations in metabolism were concomitant with a preferential incorporation of LCn-3PUFAs into muscle total membrane phospholipids (P < 0.001), in contrast to intramuscular triglycerides. These results underscore the potential role of LCn-3PUFAs as regulators of different aspects of protein metabolism in the neonate.
Combined treatment of ionizing radiation and photosensitization by 5-aminolevulinic acid-induced protoporphyrin IX.

The response of human colon adenocarcinoma cells of the line WiDr to the combined treatment of ionizing radiation and photosensitization by 5-aminolevulinic acid-induced protoporphyrin IX was assessed by a colony-forming assay. A dose of X rays inactivating approximately 50% of the cells was used. Seventy to 85% of the cells accumulated in S and G2 + M phase 12-24 h after such a treatment as measured by flow cytometry, while the distribution of cells in the phases of the cell cycle approached that of untreated cells 48 h after X-ray treatment. Cellular photosensitization was developed by endogenous synthesis of protoporphyrin IX (PPIX) from the precursor 5-aminolevulinic acid (5-ALA). This was performed by treating the cells with 1 mM 5-ALA for 4 h in a serum-free medium. The endogenous synthesis of PPIX increased with time after the cells had been subcultured, i.e. the ability of the cells to synthesize PPIX increased 1.5-2-fold within 48 h of incubation. This was not due to effects of trypsin on the cells. Photochemotherapy with 5-ALA was given 0-48 h after X rays. The combined cytotoxic effect was analyzed by an isobologram after correction of the survival curves for microcolony formation and differences in intracellular concentration of PPIX. The results indicate that 5-ALA PCT given 0-4 h after X rays acts slightly antagonistically while 5-ALA PCT given 12-48 h after X rays acts slightly synergistically.
Jejuno-ileal atresia: a 2-year preliminary study on presentation and outcome.

BACKGROUND/AIM Intestinal atresia is a common cause of neonatal intestinal obstruction. Jejuno-ileum is the commonest site of intestinal atresia. Reports on Jejunoileal atresia in developing countries are still few. The purpose of this study is to determine the presentation and management outcomes of neonates with Jejunoileal atresia treated in our hospital. MATERIALS AND METHODS Detailed data on all babies that presented and were treated within the study period (November2008-November, 2010) were kept and analyzed. A management protocol was put up and maintained. RESULT A total of 9 babies (7males and 2 females) were treated. They were aged 2 hours to 13 days. Their weight ranged from 1.7kg to 3.3kg. Apart from one baby which presented within 2hrs with prenatal ultrasound diagnosis, others had bilious vomiting from the first day of birth, abdominal distension and delayed or absent passage of meconium. Even though symptoms developed on the first day of birth, presentation to the surgical unit was delayed 72hours and beyond in most patients.Type I atresia is commonest (no=4). There is associated gut malrotation in 2 babies. Five babies had complications which included surgical site infection, sepsis, prolonged vomiting post operatively, aspiration, rupture of dilated proximal segment after membrane excision, entero-cutaneous fistula and malnutrition. Three babies died giving a mortality of 33.3%. Mortality is commoner in types IIIb and IV. CONCLUSION Mortality is higher in complex atresia which most times will require neonatal intensive care and parenteral nutrition facilities. These are still lacking in our institution. Providing these facilities will further improve outcome.
Pay for Play: Sponsored Recommendations in Information Gatekeepers

This article studies the inclusion of sponsored results in recommendations, observed in many information gatekeepers including Internet search engines, travel experts, credit raters, radio deejays, and movie critics, which are an essential entry point for many information search and decision making tasks. We develop and analyze a tractable model in which consumers may prefer or dislike the use of sponsored results in the recommendations, merchants' value for sponsorship increases with the gatekeeper's user base, and when there are negative externalities among merchants competing for consumers' attention. The optimal strategy strikes a balance between sponsorship revenues from merchants and user-based revenues. The gatekeeper's profit maximizing choice of sponsored results will, in general, deviate from the ideal level for users (which may be none, all or some, depending on the gatekeeper's technological quality and other factors). Competition among gatekeepers will cause them to make sponsorship more exclusive, which may either increase or decrease the deviation. The gatekeeper may employ sponsored recommendations even when doing so is detrimental to users, or may not present enough sponsored results even when these improve the quality of recommendations. Product innovations or better domain expertise give the gatekeeper greater flexibility in using sponsored results. Innovation by one gatekeeper has positive effect on consumer surplus as long as it does not create substantial imbalance or monopoly power. Consumer interest might be hurt if gatekeepers coordinate in setting the mix of sponsored results.
New Aspect of Renal Phosphate Reabsorption: The Type IIc Sodium-Dependent Phosphate Transporter

Abnormalities of the inorganic phosphate (Pi) reabsorption in the kidney result in various metabolic disorders. Na+-dependent Pi (Na/Pi) transporters in the brush border membrane of proximal tubular cells mediate the rate-limiting step in the overall Pi-reabsorptive process. Type IIa and type IIc Na/Pi cotransporters are expressed in the apical membrane of proximal tubular cells and mediate Na/Pi cotransport; the extent of Pi reabsorption in the proximal tubules is determined largely by the abundance of the type IIa Na/Pi cotransporter. However, several studies suggest that the type IIc cotransporter in Pi reabsorption may also play a role in this process. For example, mutation of the type IIc Na/Pi cotransporter gene results in hereditary hypophosphatemic rickets with hypercalciuria, suggesting that the type IIc transporter plays an important role in renal Pi reabsorption in humans and may be a key determinant of the plasma Pi concentration. The type IIc Na/Pi transporter is regulated by parathyroid hormone, dietary Pi, and fibroblast growth factor 23, and studies suggest a differential regulation of the IIa and IIc transporters. Indeed, differences in temporal and/or spatial expression of the type IIa and type IIc Na/Pi transporters may be required for normal phosphate homeostasis and bone development. This review will briefly summarize the regulation of renal Pi transporters in various Pi-wasting disorders and highlight the role of a relatively new member of the Na/Pi cotransporter family: the type IIc Na/Pi transporter/SLC34A3.
The FRD3 Citrate Effluxer Promotes Iron Nutrition between Symplastically Disconnected Tissues throughout Arabidopsis Development[C][W]

This work examines the role of the citrate transporter FRD3 in iron homeostasis during plant development, finding key roles in pollen and embryo development, and in leaf, in addition to its known role in roots and in the apoplastic transport of iron. We present data supporting a general role for FERRIC REDICTASE DEFECTIVE3 (FRD3), an efflux transporter of the efficient iron chelator citrate, in maintaining iron homeostasis throughout plant development. In addition to its well-known expression in root, we show that FRD3 is strongly expressed in Arabidopsis thaliana seed and flower. Consistently, frd3 loss-of-function mutants are defective in early germination and are almost completely sterile, both defects being rescued by iron and/or citrate supply. The frd3 fertility defect is caused by pollen abortion and is associated with the male gametophytic expression of FRD3. Iron imaging shows the presence of important deposits of iron on the surface of aborted pollen grains. This points to a role for FRD3 and citrate in proper iron nutrition of embryo and pollen. Based on the findings that iron acquisition in embryo, leaf, and pollen depends on FRD3, we propose that FRD3 mediated-citrate release in the apoplastic space represents an important process by which efficient iron nutrition is achieved between adjacent tissues lacking symplastic connections. These results reveal a physiological role for citrate in the apoplastic transport of iron throughout development, and provide a general model for multicellular organisms in the cell-to-cell transport of iron involving extracellular circulation.
Modified Direct Agglutination Test for Simplified Serologic Diagnosis of Leishmaniasis

ABSTRACT Human leishmaniasis is a severe health problem in many countries around the world. Hence, a cheap, reliable, and accurate diagnostic test is required to fight this disease. Perhaps the direct agglutination test (DAT) meets these criteria, but antigen elaboration involves many difficulties. We have developed a new antigen elaboration method, the EasyDAT method, that avoids the problems associated with the DAT. In this study, we compared the traditional DAT antigen method with our EasyDAT antigen method by using canine sera. The sensitivities (100%) and specificities (98.7%) were the same for both methods; we therefore concluded that the EasyDAT Leishmania antigen method simplifies serologic diagnosis, making this method easier and cheaper to use.
Why is random testing effective for partition tolerance bugs?

Random testing has proven to be an effective way to catch bugs in distributed systems in the presence of network partition faults. This is surprising, as the space of potentially faulty executions is enormous, and the bugs depend on a subtle interplay between sequences of operations and faults. We provide a theoretical justification of the effectiveness of random testing in this context. First, we show a general construction, using the probabilistic method from combinatorics, that shows that whenever a random test covers a fixed coverage goal with sufficiently high probability, a small randomly-chosen set of tests achieves full coverage with high probability. In particular, we show that our construction can give test sets exponentially smaller than systematic enumeration. Second, based on an empirical study of many bugs found by random testing in production distributed systems, we introduce notions of test coverage relating to network partition faults which are effective in finding bugs. Finally, we show using combinatorial arguments that for these notions of test coverage we introduce, we can find a lower bound on the probability that a random test covers a given goal. Our general construction then explains why random testing tools achieve good coverage---and hence, find bugs---quickly. While we formulate our results in terms of network partition faults, our construction provides a step towards rigorous analysis of random testing algorithms, and can be applicable in other scenarios.
MORB generation beneath the ultraslow spreading Southwest Indian Ridge (9–25°E): Major element chemistry and the importance of process versus source

We report highly variable mid‐ocean ridge basalt (MORB) major element and water concentrations from a single 1050‐km first‐order spreading segment on the ultraslow spreading Southwest Indian Ridge, consisting of two supersegments with strikingly different spreading geometry and ridge morphology. To the east, the 630 km long orthogonal supersegment (<10° obliquity) dominantly erupts normal MORB with progressive K/Ti enrichment from east to west. To the west is the 400 km long oblique supersegment (up to 56° obliquity) with two robust volcanic centers erupting enriched MORB and three intervening amagmatic accretionary segments erupting both N‐MORB and E‐MORB. The systematic nature of the orthogonal supersegments' ridge morphology and MORB composition ends at 16°E, where ridge physiography, lithologic abundance, crustal structure, and basalt chemistry all change dramatically. We attribute this discontinuity and the contrasting characteristics of the supersegments to localized differences in the upper mantle thermal structure brought on by variable spreading geometry. The influence of these differences on the erupted composition of MORB appears to be more significant at ultraslow spreading rates where the overall degree of melting is lower. In contrast to the moderate and rather constant degrees of partial melting along the orthogonal supersegment, suppression of mantle melting on the oblique supersegment due to thickened lithosphere means that the bulk source is not uniformly sampled, as is the former. On the oblique supersegment, more abundant mafic lithologies melt deeper thereby dominating the more enriched aggregate melt composition. While much of the local major element heterogeneity can be explained by polybaric fractional crystallization with variable H2O contents, elevated K2O and K/Ti cannot. On the basis of the chemical and tectonic relationship of these enriched and depleted basalts, their occurrence requires a multilithology mantle source. The diversity and distribution of MORB compositions, especially here at ultraslow spreading rates, is controlled not only by the heterogeneity of the underlying mantle, but also more directly by the local thermal structure of the lithosphere (i.e., spreading geometry) and its influence on melting processes. Thus at ultraslow spreading rates, process rather than source may be the principle determiner of MORB composition.
Bacteremia in Children Following Dental Extraction

The incidence and intensity of bacteremia following tooth extraction in children were measured by blood culture. The effects on bacteremia of the number and type of teeth extracted, oral hygiene, gingival health, presence of abscess, and antibiotic prophylaxis were assessed. Antibiotic prophylaxis reduced the incidence of bacteremia from 63% to 35%. The intensity of bacteremia was 2 cfu/mL of blood or less in 80% of the children. An agar pour-plate method of blood culture was significantly more effective than broth in culturing the small volumes of inoculum. Of 83 bacterial strains characterized, 39 were strict anaerobes or micro-aerophilic, and the remainder mainly streptococci. S. mitior and S. sanguis were most commonly isolated, often in pure culture, and were generally sensitive to antibiotics. No direct association was demonstrated between the plaque and gingival indices and incidence of bacteremia or between the number of teeth extracted and the incidence or intensity of bacteremia. It is concluded that all children at risk from infective endocarditis require antibiotic prophylaxis prior to tooth extraction, since it is impossible for the likelihood or intensity of transient bacteremia to be clinically predicted.
Travel-associated Diseases, Indian Ocean Islands, 1997–2010

Data collected by the GeoSentinel Surveillance Network for 1,415 ill travelers returning from Indian Ocean islands during 1997–2010 were analyzed. Malaria (from Comoros and Madagascar), acute nonparasitic diarrhea, and parasitoses were the most frequently diagnosed infectious diseases. An increase in arboviral diseases reflected the 2005 outbreak of chikungunya fever.
Adoption of On-Farm and Off-Farm Diversification to Manage Agricultural Risks

Risk is an inherent part of agricultural production, so farmers often use management strategies to reduce the adverse impacts associated with their activities. Although the use of multiple risk management strategies is common practice in farming, literature on the simultaneous adoption of multiple risk management tools is limited. This study was designed to investigate the impact of various factors on farmers' decisions to adopt on-farm and off-farm diversification and the potential for simultaneous adoption using bivariate and multinomial probit models. The results suggest that the decisions to adopt both on-farm and off-farm diversification are correlated, and adopting one risk management strategy may make it more likely that the other will be adopted simultaneously. Moreover, farm and farm household characteristics, farmers' risk perceptions and their risk attitudes are important factors that shape their risk management adoption decisions.
Fiber Optic Probe Based on Self-Assembled Photonic Crystal for Relative Humidity Sensing

This work deals with optical fiber probes based on a photonic crystal deposited on the tip of a multi-mode optical fiber for relative humidity measurements. Easy manufacturing has been exploited through the self-assembly of core/shell nanoparticles in a colloidal crystal via a vertical deposition technique. Core/shell nanoparticles are synthetized having a polystyrene core and a hydrogel poly(N-isopropylacrylamide) shell. The swelling of the hydrogel shell due to water absorption makes the reflectance spectra of the photonic crystal dependent on the relative humidity (RH) in terms of wavelength shift and amplitude change of the reflected peak. Spectral characterization and sensing analysis of experimental probes are presented and discussed, showing that the absolute spectral characteristics of the proposed device are strongly manufacturing dependent. The sensing characteristic is highly nonlinear with relative humidity. A resolution of 1% RH is measured at 30% RH that significantly decreases at higher RH. Moreover, a manufacture-independent RH sensor characteristic has been retrieved by a proper normalization of the response. Finally, a deeper insight into the sensor behavior has been obtained by a theoretical model supported by transmission electron microscope and dynamic light scattering analysis. It suggests that the clustering of the polystyrene / poly(N-isopropylacrylamide) core/shell nanoparticles is mainly responsible for the fiber optic humidity response.
Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: a role for TNF‐R1 activation by endogenous membrane‐anchored TNF

Several members of the tumour necrosis factor receptor (TNF‐R) superfamily can induce cell death. For TNF‐R1, Fas/APO‐1, DR3, DR6, TRAIL‐R1 and TRAIL‐R2, a conserved ‘death domain’ in the intracellular region couples these receptors to activation of caspases. However, it is not yet known how TNF receptor family members lacking a death domain, such as TNF‐R2, CD40, LT‐βR, CD27 or CD30, execute their death‐inducing capability. Here we demonstrate in different cellular systems that cytotoxic effects induced by TNF‐R2, CD40 and CD30 are mediated by endogenous production of TNF and autotropic or paratropic activation of TNF‐R1. In addition, stimulation of TNF‐R2 and CD40 synergistically enhances TNF‐R1‐induced cytotoxicity. These findings describe a novel pro‐apoptotic mechanism induced by some members of the TNF‐R family.
TENS for the treatment of writer’s cramp dystonia: A randomized, placebo-controlled study

Manipulation of afferent inputs may temporarily modulate dystonic spasms. Ten patients with writer’s cramp were enrolled in a double-blind, randomized, crossover study in which the effects of transcutaneous electrical stimulation (TENS) and placebo treatment were compared. Patients were evaluated using four measures of dystonic impairment. The TENS group showed a significant improvement that persisted for 3 weeks in three of the four measures.
Visually guided reaching with the forelimb contralateral to a "blind" hemisphere: a metabolic mapping study in monkeys

The 2–14C-deoxyglucose method was used to map local cerebral metabolic activity in monkeys performing a unimanual task requiring visually guided arm reaching and key pressing. The study was carried out with monkeys that either had intact brains or had one hemisphere deprived of visual input by unilateral optic tract section combined in some cases with forebrain commissurotomy. The metabolic mapping revealed activation of sensorimotor cortex only in the hemisphere contralateral to the moving forelimb, irrespective of whether this hemisphere was intact or visually deafferented. These results suggest that visually guided reaching with the forelimb contralateral to the “blind” hemisphere is subserved by that hemisphere's sensorimotor cortex and not by the cortex of the ipsilateral, “seeing” hemisphere. Other areas that were more active metabolically in the “blind” than in the “seeing” hemisphere included the supplementary motor, the secondary somatosensory, and certain posterior parietal cortical areas, intraparietal lateral 5 (lateral 5-ip), 7a, and intraparietal 7 (7-ip). It is suggested that the “blind” hemisphere utilizes at least two distinct pieces of information to guide forelimb movements to visual targets: (1) information about the location of the visual target derived from head and eye movements made to this target and mediated via the inferior parietal cortical areas 7a and 7-ip, and (2) information about the instantaneous upper extremity position derived from forelimb proprioceptive mechanisms and mediated via the somatosensory cortex and thereafter via the superior parietal cortical area, lateral 5-ip.
Effect of Moldboard Plow Types on Soil Physical Properties Under Different Soil Moisture Content and Tractor Speed

An experiment was conducted in fields of Agriculture college, University of Basrah. The experiment was designed with split-spilt plots in Complete Randomized Blocks Design Treatments included three types of moldboard plows: helical, semi digger and general –purpose, three soil moisture content levels (10.23,16.47 and 24.68%), and four tractor speed of 0.41, 0.56, 0.86 and 1.21 m sec -1 . The soil physical properties were determined after plowing soil by using three types of moldboard plow. The results showed that there was significant effect of moldboard plow types, soil moisture content and tractor speed on soil physical properties including bulk density, soil porosity, soil penetration resistance and pulverization ratio. Results also indicated that the effect of interaction among plow types, soil moisture content and tractor speed was significantly on soil penetration resistance and pulverization ratios while it had not significantly effect on bulk density, soil porosity. In general, soil physical properties, had been improved when using high tractor speed and moderate soil moisture content whereas optimal operation was obtained when using general-purpose plow type and high tractor speed of 1.12 m sec -1 and soil moisture content of 16.47% where this combination gives low bulk density (0.96Mg m-3), high soil porosity (63.90%) high soil pulverization ratio (74%) and low soil penetration resistance (623.47 kN m-2).