Miracle-dz/UniFAR-FTUs huggingface dataset:
ANALISIS PENERIMAAN SISTEM e-learning SMK LABOR PEKANBARU DENGAN MENGGUNAKAN TECHOLOGY ACCEPTANCE MODEL (TAM)

Penelitian mengenai analisis penerimaan sistem e-learning SMK Labor Pekanbaru dengan menggunakan metode Technology Acceptance Model (TAM) ini bertujuan untuk mengetahui bagaimana mengukur persepsi penerimaan siswa terhadap kemudahan pemakaian dan kemanfaatan sistem e-learning dan mengetahui faktor-faktor yang dapat mendorong siswa dalam menggunakan sistem e-learning pada SMK Labor Pekanbaru. Jenis penelitian yang dilakukan adalah jenis penelitian deskriptif dengan melakukan pengamatan dan pemantauan secara langsung pada objek penelitian dengan menggunakan instrumen penelitian berupa angket. Objek penelitian adalah siswa SMK Labor Pekanbaru sebanyak 65 orang responden yang diambil dari siswa kelas XI dan XII jurusan Teknk Komputer Jaringan. Analisis data dilakukan dengan teknik analisis deskriptif dengan menggunakan rentang kategori dan persentase melalui skala Likert. Hasil penelitian menunjukkan bahwa penerimaan sistem e-learning SMK Labor Pekanbaru untuk persepsi Kemudahan Pemakaian adalah termasuk ke dalam kategori “Sangat Puas” dengan persentase 97,45%, dan untuk persepsi Kemanfaatan adalah termasuk ke dalam kategori “Sangat Puas” dengan persentase 97,45.
Stop, kijk uit, luister, en dan...? Aandachtsontwikkeling van kinderen als voorwaarde voor hun functioneren in het verkeer

Bij verkeerstraining van jonge kinderen is het van belang dat zo goed mogelijk wordt aangesloten bij de vermogens van die kinderen. De hier beschreven lijn van onderzoek betreft dan ook het bestuderen van hun vermogens voor zover die relevant zijn voor hun verkeersdeelname als voetganger. Zie: Samenvatting
Multifaceted Lifestyle Interventions and Cardiometabolic Outcomes in Type 2 Diabetes Mellitus

Arteriosclerotic and atherosclerotic Cardiovascular Disease (CVD) is the primary cause of mortality in Type 2 Diabetes Mellitus (T2DM), accounting for more than 65-75% of all deaths in these patients [13]. The linkage of T2DM with CVD risk has led to the suggestion that common subclinical pathophysiological mechanisms predispose individuals to these conditions and cardiovascular events [4]. Subclinical CVD pathogenesis associated with metabolic syndrome (MetS) has been attributed to a combination of the established risk factors in the context of obesity and insulin and glucose metabolic dysfunction [5]. Thus, the toxic effects of dysglycemia on the vasculature may begin well before glycemic levels reach the diagnostic threshold for T2DM [6]. The MetS is also recognized as a predictor of T2DM, independent of either impaired fasting glucose (IFG) or impaired glucose tolerance (IGT) [7]. Therefore, preventative methods directed at reducing the antecedent subclinical cardiovascular complications of T2DM have been a primary strategy to diminish their impact on societal health burden [8].
Molecular characteristics of immunocytes infiltration in primary central nervous system lymphoma

Background: Primary central nervous system lymphoma (PCNSL) is a rare B-cell lymphoma of central nervous system, which is often found in immunocompromised patients. The common clinical treatment of PCNSL is methotrexate (MTX) and whole brain radiation therapy. With the development of tumour immunology research, the tumour microenvironment of PCNSL is characterised by abnormal expression of different immune signature molecules and patients with PCNSL may benefit from tumour immunotherapy. Methods: In our research, RNA-seq data from 82 PCNSL patients were collated by mining the microarray data from the GEO database. All samples were classified into three types related to tumour immune response by the Cibersort algorithm and consistent clustering. Differential analysis of genes was used to uncover 2 sets of differential genes associated with tumour immunity. The ICI scores of each sample were obtained by PCA algorithm, and the relationship between ICI scores and immune checkpoint expression, immunotherapy and drug sensitivity was investigated. Genes associated with ICI scores and their functional characteristics were investigated by WGCNA analysis and PPI analysis, based on the ICI scores of each sample. Results: The tumour microenvironment in PCNSL has a greater relationship with the tumour immune response. ICI scores obtained from 375 differential genes were associated with multiple immune responses in PCNSL. PCNSL patients with higher ICI scores had a better tumour microenvironment and were sensitive to immunotherapy and some small molecule drug. This study also identified 64 genes associated with ICI scores, which may serve as important therapeutic and prognostic targets for PCNSL. Conclusion: The presence of multiple immunosuppressive responses in the tumour microenvironment of PCNSL which suggested that improving the immune function of PCNSL patients through immunotherapy and targeted therapies can be an effective treatment for PCNSL. And the ICI score and associated genes may also provide a better predictor of the clinical use of immunotherapy.
Quality of Life of Nigerian Stroke Survivors and its Determinants

The disability caused by stroke could lead to significant decline in the level of functioning and deterioration of quality of life (QoL). QoL assessment could be used to evaluate the impact of stroke, assist in planning effective treatment, appraise efficacy of stroke rehabilitation, and evaluate cost effectiveness in order to justify expenditures on health care. This article reviewed the QoL of Nigerian stroke survivors and also identified its determinants. More than 70% of the studies on QoL of Nigerian stroke survivors have been conducted the in South Western part of Nigeria, and few from other parts of the country. The reported mean ages of stroke survivors in the published studies ranged between 54.40 years and 62.8 years. Stroke has moderate impact on QoL of Nigerian survivors, though they experienced lower QoL than their apparently healthy counterparts. The physical, social and emotional domains of QoL were all affected. Language and vision domains were however least affected. Stroke severity, disability and depression are the important predictors of QoL among Nigerian stroke survivors. The influence of motor recovery on QoL of Nigerian stroke survivors in the acute and sub-acute stages of recovery is subject to further research. Key word : determinants, quality of life, stroke, Nigeria
Review of Study of Vaginal Birth After Caesarean Section (VBAC)

Aims and Objectives: To determine the frequency and mode of delivery in women with one caesarean section and to evalu-ate the fetomaternal outcome of trial of labour of previous one caesarean section. Material and Methods: A trial of vaginal delivery was carried out on 100 patients in the Department of Obstetrics and Gynaecology of Lahore General Hospital Lahore, Descriptive study was conducted from September 2006 to September 2007. Selection criteria were subjects with normal pregnancy, adequate maternal pelvic dimensions, vertex presentation and spon-taneous onset of labour with previous one uncomplicated LSCS. Patients with classical caesarean section, medical complica-tions, multiple pregnancy, 1UGR, placenta previa and extensive myomectomy were excluded from the study. Informed con-sent was taken from all patients; trial of scar was given with vigilance. Maternal and fetal monitoring was carried out with facility of operation theatre, anesthesia and pediatrician. Results: Success vaginal delivery was achieved in 70% of the patients and repeat emergency caesarean section was carried out in 30% of the patients. Leading indication for repeat caesarean section was failure to progress, fetal distress and scar ten-derness. No maternal and fetal complication occurred. Conclusion: Trial of scar after one LSCS should be encouraged with vigilant monitoring provided no obstetric contra-indication exists. Key words: VBAC, scar tenderness, maternal mortality, LSCS.
A natação minimiza o retardo no crescimento somático e ósseo de ratos

The bone formation is regulated by hormonal factors and modified by extrinsic stimuli, such as practice of exercises. The effect of swimming on the somatic and bone growth of female rats subjected to two experimental models to reproduce hormone deficiency was assessed.Twenty-eight Wistar, neonate female rats separated in two groups: Monosodium glutamate (MGlu, n = 14; solution of monosodium glutamate 4.0mg/g, alternate days, first 14 days of life) and Saline Group (SAL, n = 14; saline solution. Body weight and measurements of somatic development (latero-lateral axis of the skull, anterior-posterior axis of the skull - LLS / APS - and length of the tail - LT) were evaluated from the 1st to the 30th day of life. At 60 days of life, the MGlu group was ovariectomized and SAL just went though surgical stress. Subsequently, half of the animals in each group started the swimming training (12 weeks, 5 days/week, 60 min/session), resulting in the following experimental groups: Sedentary saline (Sedsal, n = 7), Swimming saline (Swisal, n = 7), Sedentary glutamate ovariectomy (SedMGluO, n = 7) and Swimming glutamate ovariectomy (SwiMGluO, n = 7). At the end of the experiment, the right femur was weighed and its length assessed. At the 30 initial days, the MGlu group reduced its body weight and the LLS, APC and LT compared to SAL. At day 60, body weight of MGlu group remained lower and at the end of the experiment it was similar between Swisal and Sedsal groups; SedMGLuO and SwiMGluO groups. However, weight reduction was observed in SedMGlutO compared to SedSAL. Swimming helped the weight of the femur in the SAL and did not alter it between SedMGluO and SwiMGluO, but it increased in Sedsal compared to SedMGluO group. In length, the SwiSal was similar to Sedsal and the same situation occurred between SwiMGluO and SedMGluO. However, Sedsal group presented greater length than SedMGluO. Swimming was not able to reverse the effects caused by situations of body imbalance early induced in the bone tissue in young adult animals.
Excellent Outcome of Concomitant Intensive Immunosuppression and Eculizumab in Aplastic Anemia/Paroxysmal Nocturnal Hemoglobinuria Syndrome

A 21 year men was referred to our Institution in 2007 for mild cytopenia and laboratory signs of hemolysis (Figure 1); based on flow cytometry, the diagnosis of PNH in the context of moderate AA was made. The patient did not receive any etiologic treatment until March 2009, when he started eculizumab because of severe anemia due to overt symptomatic hemolysis. The patient had no benefit from anticomplement treatment, with increasing transfusional need; after 3 months, the diagnosis of severe AA was documented. In absence of a suitable donor, Immunosuppressive Treatment (IST) was chosen as etiologic treatment [6]; the patients was enrolled in the trial NCT00895739 [7], which investigated the anti-CD52 alemtuzumab and cyclosporine A (CyA) as an alternative IST for AA. Given the persistent major PNH population, we decided to not discontinue eculizumab to minimize the risk of massive intravascular hemolysis and possible thrombotic complications. Alemtuzumab was administered subcutaneously (3-10-30-30 mg in 4 consecutive days), without relevant side effect. Irrespective of eculizumab, immediate and profound lymphocytopenia (absolute lymphocyte count <50/μL) was observed, as in patients not receiving alemtuzumab [7]. The IST resulted in a substantial increase of neutrophil, reticulocyte and platelet counts, with the best hematological response achieved at 4 months from treatment. Unfortunately, in the following months, irrespective of chronic CyA maintenance, blood counts felt down, thus the relapse of SAA prompted us to consider a second-line treatment. Given that the best unrelated donor was 5/6 HLA matched, we opted for a second course of IST using the rabbit Anti-Thymocyte Globuline (r-ATG) associated with CyA. The treatment was completed as scheduled (3.75 mg/kg for 5 days) without any side effect, and again lymphocyte depletion was observed irrespective of continuous eculizumab treatment. After this second IST the patient experienced progressive improvement of his blood counts, finally resulting in complete response (Figure 1). Notably, reappearance of intravascular hemolysis required transient increase of eculizumab dosage; with the progressive reduction of the PNH population, eculizumab was tapered to the standard dosage. The patient now shows normal blood counts, in absence of maintenance CyA treatment and without any sign or symptom of hemolysis.
Cellular and humoral immune responses and breakthrough infections after three SARS-CoV-2 mRNA vaccine doses

Background SARS-CoV-2 vaccination has proven the most effective measure to control the COVID-19 pandemic. Booster doses are being administered with limited knowledge on their need and effect on immunity. Objective To determine the duration of specific T cells, antibodies and neutralization after 2-dose vaccination, to assess the effect of a third dose on adaptive immunity and to explore correlates of protection against breakthrough infection. Methods 12-month longitudinal assessment of SARS-CoV-2-specific T cells, IgG and neutralizing antibodies triggered by 2 BNT162b2 doses followed by a third mRNA-1273 dose in a cohort of 77 healthcare workers: 17 with SARS-CoV-2 infection prior to vaccination (recovered) and 60 naïve. Results Peak levels of cellular and humoral response were achieved 2 weeks after the second dose. Antibodies declined thereafter while T cells reached a plateau 3 months after vaccination. The decline in neutralization was specially marked in naïve individuals and it was this group who benefited most from the third dose, which resulted in a 20.9-fold increase in neutralization. Overall, recovered individuals maintained higher levels of T cells, antibodies and neutralization 1 to 6 months post-vaccination than naïve. Seventeen asymptomatic or mild SARS-CoV-2 breakthrough infections were reported during follow-up, only in naïve individuals. This viral exposure boosted adaptive immunity. High peak levels of T cells and neutralizing antibodies 15 days post-vaccination associated with protection from breakthrough infections. Conclusion Booster vaccination in naïve individuals and the inclusion of viral antigens other than spike in future vaccine formulations could be useful strategies to prevent SARS-CoV-2 breakthrough infections.
Philosophy In The Flesh The Embodied Mind And Its Challenge To Western Thought

Thank you very much for downloading philosophy in the flesh the embodied mind and its challenge to western thought. As you may know, people have search numerous times for their chosen books like this philosophy in the flesh the embodied mind and its challenge to western thought, but end up in infectious downloads. Rather than enjoying a good book with a cup of coffee in the afternoon, instead they are facing with some infectious bugs inside their computer.
Differences between Cancer Patients’ Symptoms Reported by Themselves and in Medical Records

Introduction: Data regarding rates of medical records concerning patients’ symptoms are controversial. We aimed to calculate medical discovery rate of patients’ symptoms and its association with symptoms severity. Methods: Patients reported symptoms were obtained by EORTC questionnaires of Quality of Life. Medical discovery rate was calculated after collected data on symptoms reported in medical records. Statistical descriptive methods were used. Results: There were 148 cancer patients. Most frequently reported symptoms were fatigue (80%), pain (66%), insomnia (64%). Symptoms with highest medical discovery rate were pain (19%) and nausea (14%). The remaining symptoms had low medical records discovery rate. More severe dyspnea, insomnia, nausea and constipation were more likely to be recorded by medical doctors (p<0.05). Conclusions: Majority of patients reported symptoms were not reported by doctor, even though symptoms could have been acknowledged and discussed with patients. Our results support the use of validated questionnaires to assess systematically patients’ symptoms.
A simple method for adherence evaluation to highly active antiretroviral therapy by Brazilian patients from healthcare unit: Focus on a adequately therapeutic compliance

In general, the indirect measures used to evaluate adherence to medication treatment are self-reporting, daily record of the medication use, pharmacy dispensing records, and others. This study used the indirect method analyzing the dispensing records to evaluate adherence of 295 patients treated with antiretrovirals in Health Unit of Ribeirao Preto (SP), from January 2009 to December 2011. The level of adherence, i. e. , regularity, low irregularity, high irregularity and dropout presented values of 23.7, 26.1, 46.1 and 26.4%, and over the 3 years, the dropouts showed a significant increase, with a recidivism rate ranging from 1 to 6. The correlation studies showed a negative correlation (P<0.05) between age and adherence, more pronounced in women (P<0.01). On the other hand, the changes in therapeutic prescriptions was positively correlated with the abandon (P<0.05). Based on these results, peculiarities of populations’ adherence are useful in the development of actions aiming to improve the assistance. Key words: Acquired immune deficiency syndrome virus, highly active antiretroviral therapy, medication non-adherence, correlation studies.
Effect of Nutrition Education Program Developed by a Public Health Center on Preschool Children's Nutrition Knowledge and Dietary Habits and the Parent's Dietary Attitudes

This study was carried out to examine the effects of nutrition education program developed by Jincheon Public Health Center on preschool children's nutrition knowledge and dietary habits and the parents' dietary attitudes. The subjects of this study were fiveand six-year-old children as well as their parents. A 5-week nutrition education program was implemented to 104 children in five day care centers, and 107 children in three day care centers were investigated as a control group. Activity tools designed for each lesson such as puzzles, food magnets, story, songs, Pierrot costume, and balls were used. Nutrition knowledge and dietary habits of children and dietary attitudes of parents were evaluated before and after education. Mean nutrition knowledge score in the education group was significantly higher than that in the control group after education (p < 0.001). Mean dietary habit score of three questions (three meals a day, eating at fixed time, eating breakfast) in the education group was also significantly higher than that in the control group after education (p < 0.01). In addition, parents in the education group showed significantly higher mean dietary attitude score than those in the control group even though they did not receive education (p < 0.001). Our nutrition education program was found to be effective in improving nutrition knowledge and dietary habits in preschool children as well as improving dietary attitudes in their parents. (Korean J Community Nutr 15(5) : 593~602, 2010)
Experiences of Mothers of Premature Infants Receiving Rehabilitation Therapy

Purpose: The purpose of this study was to explore and develop a deeper understanding of the experiences of mothers of premature children receiving rehabilitation therapy. Methods: The participants were 12 mothers with premature children who had received rehabilitation therapy for over 1 year. Individual in-depth interviews were conducted from July to August 2017. The data were analyzed through the phenomenological research method. Results: The participants’ experience was structured into five thematic clusters: ‘Regret and guilt that premature birth led to rehabilitation therapy’, ‘Burden of life in an endless tunnel’, ‘Changes in personal relationships surrounding me and my child’, ‘Meaning of new life through my child’, and ‘Desire to expand the rehabilitation of premature infants’. Conclusion: The results of this study will be helpful for developing family-centered care programs for premature infants at high risk of developmental disorders.
Radiotherapy in Nigeria: Current status and future challenges

Aims: Incidence of cancer is on the increase and the greater proportion of that increase is from developing countries. About 50-60% of the cancer cases will require radiotherapy at least once during the course of the treatment. This paper is an effort to appraise the present radiotherapy capacity to treat cancer in Nigeria and to project its future challenges and development. Materials and Methods: The available radiotherapy centers in Nigeria were identified and information about the types and number of radiotherapy equipments, imaging systems, personnel, and training capacity were obtained. Results: In 2001, there were five radiotherapy centers with six megavoltage therapy machines in Nigeria comprising of five cobalt-60 and one linear accelerator. The population of the country then was 120 million, that is, one therapy machine for a population of about 20 million. By the end of 2010 the number of megavoltage therapy machines has reached eight with one therapy machine situated in each of eight radiotherapy centers, but the population has equally increased to more than 155 million giving only a marginal improvement in the radiotherapy service. Conclusion: There has been an increase of radiotherapy centers in Nigeria however, the number of available facilities is grossly inadequate and there is dearth of trained personnel. Careful and strategic planning is needed to develop manpower capabilities in all fields of specialization related to radiotherapy service in order to adequately care for the multitude of cancer patients.
Serological Detection of Rotavirus Among Children with Diarrhea in Relation to Different Environmental Conditions

Rotaviruses are the single most important etiologic agents of severe diarrhea of infants and young children worldwide. In the present study, serological detection of rotavirus was done using an enzyme linked immunosorbent assay (ELISA), on 247 stool specimens. These were collected from children with acute diarrhea attending the outpatient clinic of Alexandria University Children's Hospital at El-Shatby, from October 2005 to April 2007. Rotavirus was detected in 33.6% of the collected samples; no specific age group or sex predilection was observed. It was presented with a marked seasonal peak during autumn and winter (58.3% and 40.5%, respectively). Rotavirus was found to be infecting most commonly under-weight children (46.9 %) resulting into fluid loss and severe dehydration (80%). Rotavirus acute gastroenteritis was found to be associated with fever (38.8%), vomiting (39.9%), watery stools, and long duration of diarrheal episodes lasting from one up to six days. The appearance of convulsions among rotavirus-positive cases even in the absence of fever (84.6%) was an important finding. Exclusive formula-fed infants appeared to exhibit the highest disease incidence (50%) while exclusive breast-fed infants had a lower incidence level (35.2%) of the disease. The virus was found to be significantly affecting children living in rural areas of Egypt (43.8%) rather than urban ones (26.1%). Environmental factors that were shown to affect the disease incidence include: the presence of impurities in water (41.6%), broken pipes (58.1%) and water tanks (58.7%) at the residence place. On the other hand, neither the kind of water source nor the presence of a sewage-disposal network was significantly related to the disease. Therefore, the study recommended to screen for rotavirus in children with diarrhea in order to avoid the use of unnecessary medications. In addition, encouragement of breast feeding practices and improvement of environmental conditions are important means of prevention of rotavirus infection.