Miracle-dz/UniFAR-FTUs huggingface dataset:
PARATHYROID HORMONE RELATED PROTEIN IN HYPERCALCAEMIA IN CLL

National Institute of Haematology PIROSKA PALDI-HARIS Blood Transfusion and Immunology, JANOS FOLD[ Department of Molecular Genetics, Budapest, Hungary relapse, we have plotted in Fig 1 the relative amount of chimaera mRNA in blood against the same data from the marrow sample of all our patients. BMT patients (nos. 10-16). Data from three out of the seven are shifted away from the optimal diagonal line by at least a magnitude of 1. Patient 16. 6$ years after BMT, the blood sample was bcr negative. 6 months later the marrow already presented 1% relative chimaera bcr-abl content. Since that time we could follow the relapse by alternate checking of bone marrow and blood samples. The relative chimaera content simultaneously increased in both, but it reached the 1% value in blood with a delay of 3 months. Non-treated patients (nos. 1-9). Three samples out of the nine are shifted extremely leftward (magnitude 2-6). Patient 2. On admission the patient’s blood was bcr negative. 2 months later the marrow was fully positive, but the blood presented only a very low chimaera mRNA content AlML patient (no. 17). The sample is shifted leftward by a magnitude of 4. Our data suggest that using only the peripheral blood sample for follow-up of BMT in CML patients might lead to a more optimistic judgement of the patient’s mixed chimaerism or to a delay in detection of reappearance of bcr’ cells, which might affect the choice of treatment. According to Lion et at (1993). the increase in bcr positivity has clinical importance rather than the positivity itself. This is the reason why the measurement of bcr positivity only in blood for follow-up may be sufficient in those cases, when MRD is not REFERENCES
D1 Receptor Activation Enhances Evoked Discharge in Neostriatal Medium Spiny Neurons by Modulating an L-Type Ca2+ Conductance

Most in vitro studies of D1 dopaminergic modulation of excitability in neostriatal medium spiny neurons have revealed inhibitory effects. Yet studies made in more intact preparations have shown that D1 receptors can enhance or inhibit the responses to excitatory stimuli. One explanation for these differences is that the effects of D1 receptors on excitability are dependent on changes in the membrane potential occurring in response to cortical inputs that are seen only in intact preparations. To test this hypothesis, we obtained voltage recordings from medium spiny neurons in slices and examined the impact of D1 receptor stimulation at depolarized and hyperpolarized membrane potentials. As previously reported, evoked discharge was inhibited by D1 agonists when holding at negative membrane potentials (approximately −80 mV). However, at more depolarized potentials (approximately −55 mV), D1 agonists enhanced evoked activity. At these potentials, D1 agonists or cAMP analogs prolonged or induced slow subthreshold depolarizations and increased the duration of barium- or TEA-induced Ca2+-dependent action potentials. Both effects were blocked by L-type Ca2+ channel antagonists (nicardipine, calciseptine) and were occluded by the L-type channel agonist BayK 8644—arguing that the D1 receptor-mediated effects on evoked activity at depolarized membrane potential were mediated by enhancement of L-type Ca2+ currents. These results reconcile previous in vitro and in vivostudies by showing that D1 dopamine receptor activation can either inhibit or enhance evoked activity, depending on the level of membrane depolarization.
Depressive affect and endocrine functions; blood levels of adrenal cortex and thyroid hormones in patients suffering from depressive reactions.

The significance of the adrenal cortex and the thyroid gland in the adaptation of the body to stressful life situations has been a subject of increasing interest in recent years. Evidence for the importance of these functions for vital adaptation has been reviewed previously1and in more recent publications.2,3We have reported that hospitalized psychiatric patients had elevated levels of plasma hydrocortisone (17-hydroxycorticosterone; 17-OH) and protein-bound iodine (PBI). The hydrocortisone levels were significantly higher than in controls; the PBI levels were elevated, but not significantly, when compared with those for normal control subjects. When the cases were evaluated from the viewpoint of either the intensity of emotional distress or the extent of personality disintegration, there seemed to be a correspondence between the height of the level of each hormone and the degree of clinical disturbance of the patient. Exceptionally high hormone levels were associated with very intense distress
Variability of particulate organic carbon concentration in the north polar Atlantic based on ocean color observations with Sea-viewing Wide Field-of-view Sensor (SeaWiFS)

POC throughout the season. The lowest values, generally less than 200 mg m 3 , and at some locations often less than 50 mg m 3 , were observed in April. In May and June, POC can exceed 300 or even 400 mg m 3 in some parts of the study region. Patterns of interannual variability are intricate, as they depend on the geographic location within the study region and particular time of year (month) considered. By comparing the results averaged over the entire study region and the entire season (April through August) for each year separately, we found that the lowest POC occurred in 2001 and the highest POC occurred in 2002 and 1999.
Effects of clozapine on smoking in chronic schizophrenic outpatients.

BACKGROUND The effects of clozapine administration on smoking were examined in chronic schizophrenic outpatients. METHOD Twenty-nine of 30 schizophrenic outpatients enrolled in a university-affiliated Community Mental Health Center clozapine clinic were retrospectively surveyed by semistructured questionnaire regarding smoking before and after clozapine administration. RESULTS Smokers comprised 62% (N = 18) of patients, and within this group, there was a significant decrease in reported daily cigarette use during clozapine treatment compared with level of use when patients had been treated with typical neuroleptics (1.67 +/- 1.13 vs. 1.26 +/- 0.72 packs/day, p = .025). CONCLUSION Clozapine may alter smoking behaviors in chronic schizophrenics.
Requirement for membrane potential in active transport of glutamine by Escherichia coli

The effect of reducing the membrane potential on glutamine transport in cells of Escherichia coli has been investigated. Addition of valinomycin to tris(hydroxymethyl)aminomethane-ethylenediaminetetraacetic acid-treated E. coli cells in the presence of 20 mM exogenous potassium reduced the membrane potential, as measured by the uptake of the lipophilic cation triphenylmethylphosphonium, and caused a complete inhibition of glutamine transport. Valinomycin plus potassium also caused a rapid decrease in the intracellular levels of ATP of normal E. coli cells, but had little if any effect on the ATP levels of two mutants of E. coli carrying lesions in the energy-transducing ATP complex (unc mutants). Yet both the membrane potential and the capacity to transport glutamine were depressed in the unc mutants by valinomycin and potassium. These findings are consistent with the hypothesis that both ATP and a membrane potential are essential to the active transport of glutamine by E. coli cells.
Anti-Amnesic Activity of Vitex Negundo in Scopolamine Induced Amnesia in Rats

In the present study we investigated the anti-amnesic activity of Vitex negundo in scopolamine induced amnesia in rats. Wistar rats (180-200 g) were trained on active avoidance task. Each animal received session of 15 trials with inter trial duration of 15 s for 5 days. Scopolamine (3 mg/kg, i.p) was administered at different time periods on the basis of stages of memory i.e acquisition, consolidation and retention in different groups (n = 6). Effect of Vitex negundo extract was evaluated and compared to a standard drug, Donepezil. Significant (p < 0.05) increase in the avoidance response on the 5th session has been observed as compared to 1st session in control group. Scopolamine treatment significantly (p < 0.05) reduced the avoidance response compared to control. Extract treated groups shown significant (p < 0.05) increase in number of avoidance responses as compared to scopolamine treated groups. Increased oxidative stress in brain after scopolamine treatment, as observed by increase in MDA & decrease in GSH & SOD, was lowered in the groups treated with extracts. AChE activity was also improved after V. negundo treatment. Results of the study have shown that V. negundo treated groups decrease the phenomenon of amnesia by increasing learning of memory through antioxidant effect and decreasing AChE activity.
Evaluation of the 7(th) edition of the UICC-AJCC tumor, node, metastasis classification for esophageal cancer in a Chinese cohort.

BACKGROUND To assess and evaluate the prognostic value of the 7(th) edition of the Union for International Cancer Control-American Joint Committee on Cancer (UICC-AJCC) tumor, node, metastasis (TNM) staging system for Chinese patients with esophageal cancer in comparison with the 6(th) edition. METHODS A retrospective review was performed on 766 consecutive esophageal cancer patients treated with esophagectomy between 2008 and 2012. Patients were staged according to the 6(th) and 7(th) editions for esophageal cancer respectively. Survival was calculated by the Kaplan-Meier method, and multivariate analysis was performed using Cox regression model. RESULTS Overall 3-year survival rate was 59.5%. There were significant differences in 3-year survival rates among T stages both according to the 6(th) edition and the 7(th) edition (P<0.001). According to the 7(th) edition, the 3-year survival rates of N0 (75.4%), N1 (65.2%), N2 (39.7%) and N3 (27.3%) patients were significant differences (P<0.001). Kaplan-Meier curve revealed a good discriminatory ability from stage I to IV, except for stage IB, IIA and IIB in the 7(th) edition staging system. Based on the 7(th) edition, the degree of differentiation, tumor length and tumor location were not independent prognostic factors on multivariate analysis. The multivariate analyses suggested that pT-, pN-, pTNM-category were all the independent prognostic factors based on the 6(th) and 7(th) edition staging system. CONCLUSIONS The 7(th) edition of AJCC TNM staging system of esophageal cancer should discriminate pT2-3N0M0 (stage IB, IIA and IIB) better when considering the esophageal squamous cell cancer patients. Therefore, to improve and optimize the AJCC TNM classification for Chinese patients with esophageal cancer, more considerations about the value of tumor grade and tumor location in pT2-3N0M0 esophageal squamous cell cancer should be taken in the next new TNM staging system.
Dietary influences on tissue concentrations of phytanic acid and AMACR expression in the benign human prostate

Alpha‐methylacyl‐CoA racemase (AMACR) is an enzyme involved in fatty acid metabolism that is markedly over‐expressed in virtually all prostate cancers (PCa), relative to benign tissue. One of AMACR's primary substrates, phytanic acid, is derived predominately from red meat and dairy product consumption. Epidemiological evidence suggests links between dairy/red meat intake, as well as phytanic acid levels, and elevated PCa risk. This study investigates the relationships among dietary intake, serum and tissue concentrations of phytanic acid, and AMACR expression (mRNA and protein) in the histologically benign human prostate.
Early versus late diagnosis: psychological impact on parents of children with cystic fibrosis.

OBJECTIVES To explore the relationship between the period preceding diagnosis and the way parents of children with cystic fibrosis (CF) experience and handle their child's disease. DESIGN A retrospective study. SETTING CF Center "Noordwest Nederland," the Netherlands. PARTICIPANTS Participants were the parents of children <13 years old with CF who were treated at the CF Center "Noordwest Nederland. " The participants were divided into 2 groups according to the duration of prediagnostic period: <3 months (defined as early diagnosis) and >or=3 months (defined as late diagnosis). MAIN OUTCOME MEASURES Experience of the prediagnostic period, contact with the medical profession, coping, future perspective, and attitudes toward neonatal screening for CF. RESULTS Parents of 55 children were eligible for study participation; 45 were enrolled. Retrospectively, the period preceding an early diagnosis was less negatively experienced by parents than the period preceding a late diagnosis. Parents of children with an early diagnosis had retrospectively more confidence in the medical profession before confirmation of diagnosis. In general, parents in this study used adaptive coping styles. Duration of prediagnostic period was not significantly related to future perspective. Hopelessness seemed to be mainly determined by a severe course of disease as experienced by the parents. Ninety-eight percent of all parents were in favor of neonatal screening for CF. CONCLUSIONS A short prediagnostic period is associated with less negative feelings and increased confidence in the medical profession among parents of children with CF. Neonatal screening for CF may be of benefit to parents by removing the stress of a delayed diagnosis.
Therapeutic Effects of Breviscapine in Cardiovascular Diseases: A Review

Breviscapine is a crude extract of several flavonoids of Erigeron breviscapus (Vant.) Hand. -Mazz. , containing more than 85% of scutellarin, which has been traditionally used in China as an activating blood circulation medicine to improve cerebral blood supply. Accumulating evidence from various in vivo and in vitro studies has shown that breviscapine exerts a broad range of cardiovascular pharmacological effects, including vasodilation, protection against ischaemia/reperfusion (I/R), anti-inflammation, anticoagulation, antithrombosis, endothelial protection, myocardial protection, reduction of smooth muscle cell migration and proliferation, anticardiac remodeling, antiarrhythmia, blood lipid reduction, and improvement of erectile dysfunction. In addition, several clinical studies have reported that breviscapine could be used in conjunction with Western medicine for cardiovascular diseases (CVDs) including coronary heart disease, myocardial infarction, hypertension, atrial fibrillation, hyperlipidaemia, viral myocarditis, chronic heart failure, and pulmonary heart disease. However, the protective effects of breviscapine on CVDs based on experimental studies along with its underlying mechanisms have not been reviewed systematically. This paper reviewed the underlying pharmacological mechanisms in the cardioprotective effects of breviscapine and elucidated its clinical applications.
Sprint mechanics in world‐class athletes: a new insight into the limits of human locomotion

The objective of this study was to characterize the mechanics of maximal running sprint acceleration in high‐level athletes. Four elite (100‐m best time 9.95–10.29 s) and five sub‐elite (10.40–10.60 s) sprinters performed seven sprints in overground conditions. A single virtual 40‐m sprint was reconstructed and kinetics parameters were calculated for each step using a force platform system and video analyses. Anteroposterior force (FY), power (PY), and the ratio of the horizontal force component to the resultant (total) force (RF, which reflects the orientation of the resultant ground reaction force for each support phase) were computed as a function of velocity (V). FY‐V, RF‐V, and PY‐V relationships were well described by significant linear (mean R2 of 0.892 ± 0.049 and 0.950 ± 0.023) and quadratic (mean R2 = 0.732 ± 0.114) models, respectively. The current study allows a better understanding of the mechanics of the sprint acceleration notably by modeling the relationships between the forward velocity and the main mechanical key variables of the sprint. As these findings partly concern world‐class sprinters tested in overground conditions, they give new insights into some aspects of the biomechanical limits of human locomotion.
EXPECTED CREDIT LOSS MODEL BY IFRS 9 AND ITS POSSIBLE EARLY IMPACTS ON EUROPEAN AND TURKISH BANKING SECTOR

OZ Uluslararasi Muhasebe Standartlari Kurulu, 2014 yilinin Temmuz ayinda, UMS 39'un “Finansal Araclar: Muhasebelestirme ve Olcme”nin yerine UFRS 9 - “Finansal Araclar” Standardini yayinlamistir. Yeni standart 1 Ocak 2018'den itibaren yuruluge girmistir. Yeni standarttaki en onemli degisiklik, “deger dusuklugu” bolumunde yapilan "Gerceklesen Kredi Zararlari" yerine "Beklenen Kredi Zararlari" uygulamasidir. Bu calismada, yeni standarda gore deger dusuklugu karsiliklarinin olcumu ve muhasebelestirilmesi aciklandiktan sonra, Avrupa Bankacilik Sektorunde bu gecisin beklenen muhtemel nitel ve nicel etkileri analiz edilip, sonuclari Turk Bankacilik Sektoru ile karsilastirilmistir. Avrupa’da bu gecis sonucu, karsiliklarin ortalama olarak % 13 -% 18 araliginda artmasi, buna bagli olarak da cekirdek sermaye ve toplam sermaye yeterliligi rasyosunda sirasiyla, ortalama 45-75 ve 35-50 baz puanlik dusus beklenmektedir. Turkiye’deki beklenti ise, sonuclarin tam tersi yonde olacagidir. Turkiye’deki bankalar icin toplam karsiliklar tutarinin % 4,1 dusmesi ve cekirdek sermaye ve toplam sermaye yeterliligi rasyolarinda ise, sirasiyla, 33 ve 21 baz puanlik pozitif etki olmasi beklenmektedir.
Single-Event Charge Collection and Upset in 40-nm Dual- and Triple-Well Bulk CMOS SRAMs

CMOS technologies can be either dual-well or triple-well. Triple-well technology has several advantages compared to dual-well technology in terms of electrical performance. Differences in the ion-induced single-event response between these two technology options, however, are not well understood. This paper presents a comparative analysis of heavy ion-induced upsets in dual-well and triple-well 40-nm CMOS SRAMs. Primary factors affecting the charge-collection mechanisms for a wide range of particle energies are investigated, showing that triple-well technologies are more vulnerable to low-LET particles, while dual-well technologies are more vulnerable to high-LET particles. For the triple-well technology, charge confinement and multiple-transistor charge collection triggers the “Single Event Upset Reversal” mechanism that reduces sensitivity at higher LETs.
Improved spectral clustering collaborative filtering with Node2vec technology

Recommender systems are becoming part of our lives and make many online systems getting smarter. However, with the fast increasing amount of users, items, and the interactions between the two, many traditional recommendation methods encounter the challenges of sparsity and efficiency. Clustering-based recommendation is a common strategy to overcome these problems, but many of them rely heavily on parameter settings. In this work, we put forward an improved spectral clustering-based collaborative filtering framework based on node2vec algorithm, named as N2VSCDNN, to tackle these challenges and lead to a significantly increment of accuracy. We represent interaction data as a bipartite network and employ node2vec technology to automatically capture complex latent relationship among users or items from the corresponding projection networks. In order to overcome the information loss problem and reduce the dependency on parameter settings, We proposed an improved parameter-free spectral clustering based on dynamic nearest-neighbors to cluster users and items separately. After partitions of the nodes, we generate recommendation over the most frequent pairwise user-item clusters and merge the results to conduct a top-N list for every individual user. Finally, We demonstrate the effectiveness of our proposed framework on a real-world benchmark dataset Yelp.
Agent of Whirling Disease Meets Orphan Worm: Phylogenomic Analyses Firmly Place Myxozoa in Cnidaria

Myxozoa are microscopic obligate endoparasites with complex live cycles. Representatives are Myxobolus cerebralis, the causative agent of whirling disease in salmonids, and the enigmatic “orphan worm” Buddenbrockia plumatellae parasitizing in Bryozoa. Originally, Myxozoa were classified as protists, but later several metazoan characteristics were reported. However, their phylogenetic relationships remained doubtful. Some molecular phylogenetic analyses placed them as sister group to or even within Bilateria, whereas the possession of polar capsules that are similar to nematocysts of Cnidaria and of minicollagen genes suggest a close relationship between Myxozoa and Cnidaria. EST data of Buddenbrockia also indicated a cnidarian origin of Myxozoa, but were not sufficient to reject a closer relationship to bilaterians. Phylogenomic analyses of new genomic sequences of Myxobolus cerebralis firmly place Myxozoa as sister group to Medusozoa within Cnidaria. Based on the new dataset, the alternative hypothesis that Myxozoa form a clade with Bilateria can be rejected using topology tests. Sensitivity analyses indicate that this result is not affected by long branch attraction artifacts or compositional bias.
Tetrathionate reduction and production of hydrogen sulfide from thiosulfate

In the biological sulfur cycle as presented in most textbooks of microbiology, reduced free sulfur (hydrogen sulfide) is produced in two different ways. It is the product of sulfate reduction by a unique group of anaerobic bacteria that includes Desulfovibrio and Desulfotomaculum, and it is released from organic matter without any change in oxidation state during processes of protein decomposition by a variety of other microorganisms. Although many organisms assimilate sulfate and reduce it for their biosynthetic needs, dissimilatory sulfate reduction appears to be performed exclusively by the sulfate-reducing bacteria (130). They obtain energy by means of an anaerobic respiration in which sulfate serves as the primary electron acceptor, although they can also use partially oxidized sulfur compounds for their energy needs (127, 130). These bacteria are typically found in mud or waterlogged soil that contains organic matter and oxidized sulfur (138). When hydrogen sulfide is found in other environments, it is generally assumed to be the product of protein decomposition.
Folliculitis keloidalis nuchae is associated with the risk for bleeding from haircuts

Background Folliculitis keloidalis nuchae (FKN), characterized by nucheal pimples and keloids, has a predilection for curly African hair. The disease is 10 times more common in males than females. The aim of this study was to investigate determinants of FKN in males.
The Pol β-14 Dominant Negative Rat DNA Polymerase β Mutator Mutant Commits Errors during the Gap-Filling Step of Base Excision Repair in Saccharomyces cerevisiae

ABSTRACT We demonstrated recently that dominant negative mutants of rat DNA polymerase β (Pol β) interfere with repair of alkylation damage inSaccharomyces cerevisiae. To identify the alkylation repair pathway that is disrupted by the Pol β dominant negative mutants, we studied the epistatic relationship of the dominant negative Pol β mutants to genes known to be involved in repair of DNA alkylation damage in S. cerevisiae. We demonstrate that the rat Pol β mutants interfere with the base excision repair pathway in S. cerevisiae. In addition, expression of one of the Pol β dominant negative mutants, Pol β-14, increases the spontaneous mutation rate of S. cerevisiae whereas expression of another Pol β dominant negative mutant, Pol β-TR, does not. Expression of the Pol β-14 mutant in cells lacking APN1 activity does not result in an increase in the spontaneous mutation rate. These results suggest that gaps are required for mutagenesis to occur in the presence of Pol β-14 but that it is not merely the presence of a gap that results in mutagenesis. Our results suggest that mutagenesis can occur during the gap-filling step of base excision repair in vivo.