Miracle-dz/UniFAR-FTUs huggingface dataset:
Title : Pretargeted radioimmunotherapy using genetically engineered antibody-streptavidin fusion proteins for treatment of non-hodgkin lymphoma

Purpose—Pretargeted radioimmunotherapy (PRIT) using streptavidin (SAv)-biotin technology can deliver higher therapeutic doses of radioactivity to tumors than conventional RIT. However, “endogenous” biotin can interfere with the effectiveness of this approach by blocking binding of radiolabeled biotin to SAv. We engineered a series of SAv FPs that down-modulate the affinity of SAv for biotin, while retaining high avidity for divalent DOTA-bis-biotin to circumvent this problem. Experimental Design—The single-chain variable region gene of the murine 1F5 anti-CD20 antibody was fused to the wild-type (WT) SAv gene and to mutant SAv genes, Y43A-SAv and S45A-SAv. FPs were expressed, purified and compared in studies using athymic mice bearing Ramos lymphoma xenografts. Results—Biodistribution studies demonstrated delivery of more radioactivity to tumors of mice pretargeted with mutant SAv FPs followed by 111In-DOTA-bis-biotin (6.2 ± 1.7 % of the injected dose per gram [%ID/gm] of tumor 24 hours after Y43A-SAv FP and 5.6 ± 2.2 %ID/g with S45ASAv FP) than in mice on normal diets pretargeted with WT-SAv FP (2.5 ± 1.6 %ID/g; p = 0.01). These superior biodistributions translated into superior anti-tumor efficacy in mice treated with mutant FPs and 90Y-DOTA-bis-biotin (tumor volumes after 11 days: 237 ± 66 mm3 with Y43ACorresponding Author: NAME: Oliver Press, M.D., Ph.D. INSTITUTION: Fred Hutchinson Cancer Research Center STREET: 1100 Fairview Ave N, M/S D3-395 CITY, STATE: Seattle, WA 98109 PHONE: (206) 667-1864 FAX: (206) 667-1874 press@u.washington. edu . #These investigators contributed equally to this manuscript and are therefore assigned as co-first authors in alphabetical order. Author contributions: SI Park designed and performed research, analyzed data, and drafted the manuscript. J Shenoi designed and performed research, analyzed data, and drafted the manuscript. S Frayo performed research, collected data, and analyzed data. DK Hamlin contributed vital reagents and performed research. Y Lin engineered, expressed, purified, and tested the fusion proteins. PS Stayton produced the mutant streptavidin gene constructs by directed mutagenesis. DS Wilbur contributed to the conception, design, analysis, and interpretation of research. N Orgun, A Kenoyer, and A Axtman performed research and collected data. M Hylarides, contributed vital reagents, design and interpretation of research, F Buchegger performed research and analyzed data. AK Gopal and DJ Green contributed to the interpretation of data. JM Pagel contributed to the conception, design, analysis, interpretation of research, and edited the manuscript. OW Press contributed to the conception, design, analysis and interpretation of research, revised the manuscript and funded the experiments. NIH Public Access
Modeling and simulation of CZTS-perovskite sandwiched tandem solar cell

In this research work, a solar cell capacitance simulator (SCAPS-1D) was used in the modeling and simulation of sandwiched perovskite solar cells (PSCSs) with a planar heterojunction structure in the arrangement of the sandwiched model (FTO/ZnO/CZTS/PSCS/CZTS/HTM). Two different configurations, 121 and 111, of the sandwiching absorber layer of the device were simulated and compared with the perovskite without sandwiching, using an absorber layer of step length thickness of 25 nm, and varied from 100 nm to 500 nm. The band gap diagram, I-V characteristics curve, and other parameters were constructed. The best configuration for better performance was then determined, from which further simulations were carried out. Efficiency of 22.57% was achieved, which shows that having a combination of two different absorbers was achievable with considerable photon conversion efficiency.
Determinants of Survival of Newly Created SMEs in the Brazilian Manufacturing: An Econometric Study

The paper investigates the survival of newly created small and medium enterprises in Brazilian manufacturing taking as reference the 1996-2005 period. The econometric analysis relies on time-varying version of the proportional hazard rate model that controls for unobserved heterogeneity. The evidence mostly corroborates previous findings for developed countries. Salient results include the positive role played by firm size, industry size and industry growth on survival and yet the negative influence exerted by industrial concentration and entry rate.
An investigation into murine pericyte shape change in response to inflammatory stimuli in vitro and in vivo

3 Table of contents . 4 List of Figures . 10 List of Tables . 14 Abbreviations . 15 List of presentations at national and international meetings . 18 Publications arising from this work . 19 Statement of Originality . 20 Chapter 1: General Introduction . 21 1.1 Inflammation . 22 1.2 The leukocyte adhesion cascade . 25 1.2. 1 Leukocyte capture and rolling . 26 1.2. 2 Leukocyte arrest and intravascular crawling to sites of transendothelial migration . 29 1.2. 3 Leukocyte transmigration through the endothelial layer . 31 1.3 Pericytes and the venular basement membrane: Additional barriers for transmigrating leukocytes . 36 1.4 Pericytes . 40
Robot-assisted radical prostatectomy in Brazil: preliminary results

Purpose: To report the initial experience on robot-assisted radical prostatectomy in Brazil. Methods: From March 2008 to March 2009, a hundred patients were treated with robot-assisted radical prostatectomy. Patients demographic data, as well as perioperative results of the procedures, are described in this study. Results: Patients mean age and mean PSA were 58 years and 7.58 ng/ml, respectively. All procedures were performed through transperitoneal approach, with a mean bleeding of 480 mL and surgical time of 298 minutes. A surgical margin affected by cancer was present in 16% of the cases. There were four complications: bleeding requiring transfusion (two cases), rectal perforation corrected on the spot and inadequate functioning of the robot. There was no conversion to another access or obit occurrences in this caseload. Conclusions: Robot-assisted prostatectomy is a reality in Brazil and the results herein presented demonstrate that this procedure can be safely performed. Long-term follow-up is still necessary to assess the oncological and functional outcomes. Objetivo: Relatar a experiencia inicial de prostatectomia radical robo-assistida realizada no Brasil. Metodos: No periodo de marco de 2008 a marco de 2009, cem pacientes foram tratados com a prostatectomia radical robo-assistida. Os dados demograficos dos pacientes, assim como os resultados perioperatorios dos procedimentos, sao descritos neste estudo. Resultados: A media de idade e PSA dos pacientes foi de 58 anos e 7,58 ng/ml, respectivamente. Todos os procedimentos foram realizados por via transperitoneal, com sangramento medio foi de 480 ml e tempo cirurgico de 298 minutos. A presenca de margem cirurgica comprometida por câncer ocorreu em 16% dos casos. Ocorreram quatro complicacoes: sangramento com necessidade de transfusao (dois casos), perfuracao retal corrigida no ato e funcionamento inadequado do robo. Nao houve conversao para outro acesso ou obitos nesta casuistica. Conclusoes: A prostatectomia robotica e uma realidade no Brasil e os resultados apresentados demonstram que este procedimento pode ser realizado com seguranca. Seguimento a longo prazo ainda e necessario para avaliar os resultados oncologicos e funcionais.
Modeling The Potential Distribution of Turkish Oak ( Quercus cerris L . ) in Kunduz District ( Vezirköprü )

Anahtar Kelimeler Çevresel faktörler, Meşe, Potansiyel tür dağılım modeli, Yükselti Özet: Saçlı meşe (Quercus cerris L.) ülkemizin tepelik ve dağlık orman alanlarında yayılış gösteren önemli ağaç türlerimizden birisidir. Bu çalışmada türün Kunduz Yöresi (Vezirköprü) sınırları içerisinde var‐yok verilerinden faydalanılarak Sınıflandırma ve Regresyon Ağacı Tekniği (SRAT) ile potansiyel dağılım alanlarının modellenmesi amaçlanmıştır. Bu amaçla 2014 ve 2015 yaz ayları boyunca toplam 586 örnek alanda (100x100 m) arazi çalışması yapılmıştır. Çalışmada toplam 223 örnek alanda saçlı meşe türü tespit edilmiştir. Ayrıca yöre için oluşturulan sayısal altlıklardan faydalanılarak bağımsız değişken konumunda toplam 21 adet çevresel değişken verisi elde edilmiştir. Daha sonra bu değişkenler ile yapılan istatistiksel değerlendirmeler neticesinde türün yöredeki potansiyel dağılım alanları modellenmiştir. SRAT yönteminden elde edilen sonuçlara göre türün yöredeki potansiyel dağılımında etkili olan değişkenlerin sırasıyla yükselti, radyasyon indeksi ve matakumtaşı anakaya formasyonları olduğu tespit edilmiştir. Bu durum yörede yükseltiye bağlı olarak meydana gelen iklimsel değişimlerin türün potansiyel dağılımına etki eden en önemli faktör olduğu sonucunu ortaya çıkarmaktadır. Dolaysıyla bu tür ile yörede yapılacak orman işletmecilik faaliyetlerinde iklim özelliklerinin mutlak suretle göz önünde bulundurulması gerekmektedir. Diğer yandan modelde radyasyon indeksi ve anakaya formasyonunun önem arz etmesi ise yörede türün potansiyel dağılımında kısmen lokal iklim ve toprak koşullarının da etkili olabileceği sonucunu ortaya çıkarmıştır.
Nutrient – Gene Interactions Methylenetetrahydrofolate Reductase 677 C 3 T Variant Modulates Folate Status Response to Controlled Folate Intakes in Young Women 1 , 2

A common genetic variant in the methylenetetrahydrofolate reductase (MTHFR) gene involving a cytosine to thymidine (C3T) transition at nucleotide 677 is associated with reduced enzyme activity, altered folate status and potentially higher folate requirements. The objectives of this study were to investigate the effect of the MTHFR 677 T allele on folate status variables in Mexican women (n 43; 18–45 y) and to assess the adequacy of the 1998 folate U.S. Recommended Dietary Allowance (RDA), 400 g/d as dietary folate equivalents (DFE). Subjects (14 CC, 12 CT, 17 TT genotypes) consumed a low folate diet (135 g/d DFE) for 7 wk followed by repletion with 400 g/d DFE (7 CC, 6 CT, 9 TT) or 800 g/d DFE (7 CC, 6 CT, 8 TT) for 7 wk. Throughout repletion with 400 g/d DFE, the TT genotype had lower (P 0.05) serum folate and higher (P 0.05) plasma total homocysteine (tHcy) concentrations than the CC genotype. CT heterozygotes did not differ (P 0.05) in their response relative to the CC genotype. Throughout repletion with 800 g/d DFE, the CT genotype had lower (P 0.05) serum folate concentrations and excreted less (P 0.05) urinary folate than the CC genotype. However, there were no differences (P 0.05) in the measured variables between the TT and CC genotypes. Repletion with 400 g/d DFE led to normal blood folate and desirable plasma tHcy concentrations, regardless of MTHFR C677T genotype. Collectively, these data demonstrate that the MTHFR C3T variant modulates folate status response to controlled folate intakes and support the adequacy of the 1998 folate U.S. RDA for all three MTHFR C677T genotypes. J. Nutr. 133: 1272–1280, 2003.
Halmstad University

In spite of the need for organisations to develop competencies among its employees as a source for gaining competitive advantage, and in spite of previous research efforts to find out what contributes to it and the effects of it, the process of Competence Development (CD) implementation is still a ‘black box’, whose internal linkages are unknown. Furthermore it is noticed in previous research that there is a lack of empirically-based research in organisations, and the purpose of this dissertation is therefore to explore the process of CD implementation, as perceived by employees within the debt-collection industry of Sweden. A case-study on a Swedish Debt-Collection Company was conducted, and data collected through interviews with employees and managers, in order to find out how the process of CD implementation is structured. In order to investigate the internal linkages in the process an extensive literature review was performed in the field of CD, and used for developing a conceptual model, showing how the various stages interact and depend upon each other in gaining competence among its employees. The model was then tested empirically and the findings suggest that the CD implementation was structured mostly in line with the model, although adjustments had to be made. The findings suggest that in the process of CD implementation conceptualisation of CD plans and selection of participants is conducted in one integrated step and not two distinct steps, as suggested in previous literature. Performance Management and Reflectionand Evaluation are not conducted in two steps but more or less simultaneously. Furthermore, this study suggests that it is the organisation’s responsibility to provide a foundation, opportunities and resources that enable CD, while the employees themselves set the standard for how much they will take advantage of it. Therefore this study argues that if employees can have input and influence on each stage of the process, better outcomes will be provided since it will be aligned with their objectives, personal and professional. Up to this point, the process of CD implementation has been a ‘black box’, a mechanism that generates a certain level of output but whose internal workings are unknown. It is important to open up that box and to understand how CD operates to produce superior performance for an organisation. The findings in this study help to bridge that gap better, and are useful for managers conducting and implementing Human Resource practices that aim to develop competencies among the company’s workforce in order to gain better performance.
EFFECT OF CADMIUM AND KINETIN ON TRANSPIRATION RATE , STOMATAL OPENING AND LEAF RELATIVE WATER CONTENT IN SAFFLOWER

The effects of cadmium and kinetin on transpiration rate, stomatal opening and leaf relative water content were studied in safflower (Carthamus tinctorius) plants. Pollution of the root environment with concentration of cadmium ranging from 3 to 30 μM, supplied as CdCI2, reduced leaf area, transpiration rate, stomatal opening and leaf relative water content. Transpiration rates were reduced to 59, 60, 55 and 48% of those in the control plants at 3, 10, 20 and 30 μM Cd, respectively. Reduction in transpiration due to higher cadmium contaminators is quite large at noon unlike that in the early morning or late afternoon. Kinetin greatly reduced or reversed the inhibitory effect of cadmium. Kinetin-treated plants generally showed a significantly higher transpiration rate, larger stomatal aperture and higher leaf turgidity than those untreated plants. Kinetin also increased leaf area significantly at higher Cd concentration. The highest kinetin concentration used was most effective in this respect. The results proved that cadmium mediated reduction in transpiration rate, stomatal opening and leaf turgidity are effectively reversed by kinetin.
Attitudes of Rural School Principals toward Inclusive Practices and Placements for Students with Severe Disabilities

Principals, as instructional leaders, are instrumental in leading initiatives in special education. In this study, rural principals were, overall, more likely to consider the self-contained classroom to be the most appropriate placement for disabled students. Of these principals, those with personal experience with disabled students were more likely to consider inclusive placements.
MODULE 5. LICE: INSECTICIDE RESISTANCE: DIAGNOSIS, MANAGEMENT AND PREVENTION

Lice (Phthiraptera) are wingless, dorso-ventrally flattened, permanent ectoparasites of birds and mammals. Over 3000 species have been described, mainly parasites of birds, and are divided into four readily recognizable groups (Anoplura, Rhynchophthirina, Amblycera and Ischnocera) (Kettle, 1995). Simplistically the Anoplura (and Rhynchophthirina) are blood-sucking lice and the Amblycera and Ischnocera (collectively known as the Mallophaga (“wool eaters”)) are chewing lice (erroneously called “biting lice”), feeding on skin debris and hair. Lice infest a wide range of domestic livestock, including pigs, cattle, goats and sheep (Table 1) and cause a chronic dermatitis (pediculosis), characterized by constant irritation, itching, rubbing and tagging and biting of the hair or fleece. Lice are closely adapted to their hosts and completely dependent upon them for survival.
THE EFFECT OF ULTRASOUND ON THROMBOLYSIS : The rationale for EKOS TM Acoustic Pulse Thrombolysis TM Therapy

A small number of recent clinical studies have focused discussion on the efficacy of ultrasound in enhancing thrombolysis. The results and the conclusions they have drawn have raised some debate about the need for ultrasound to enhance thrombolysis, despite the body of research over the past few decades on this topic. One can certainly argue about study design and number of patients, validation of measurement systems, and the finer points of methodology surrounding these studies. However, it is more illuminating to review what has already been firmly established about ultrasound and its effects on fibrinolysis including its mechanism of action and the supporting evidence.
Political information, firm value and information networks: Evidence from the Chinese National Social Security Fund

The purpose of this paper is to analyze the existence and impact of the policy information advantage, held by a government-backed institutional investor, on firm performance. The Chinese National Social Security fund (CNSSF) is used as our “laboratory” – wherein the CNSSF represents a major state sponsoring institutional investor in China with dual roles and a deep information network. Our results show a short-run positive and significant information advantagestock performance linkage. In contrast, the long-run linkage is negative. We document that there is a network spillover of the information advantage across the Chinese mutual fund industry.
Rollover Risk and Bank Lending Behavior ∗

How does a sudden extension of bank debt maturity affect bank lending in times of crisis? We use the provision of long-term funding by the 2011 European Central Bank’s (ECB) very long-term refinancing operations (vLTRO) as a quasi-natural experiment to address this question. Our analysis employs a novel dataset that matches the ECB monetary policy and market operations data with the firm credit registry and banks’ security holdings in Portugal. We show that lengthening of bank debt maturity in crisis times has a positive and economically sizable impact on bank lending and the real economy. The effects are stronger on the supply of credit to smaller, younger, riskier firms and firms with shorter lending relationships. We also find that loan-level results translate to real and credit effects at the firm level. Finally, we discuss policy side-effects and show how the unrestricted liquidity provision provided incentives to banks to purchase more securities and partially substituted away from lending to the real economy. JEL classification: E44, E52, E58, G21, G32
THERE IS NO INNATE TROCHAIC BIAS : ACOUSTIC EVIDENCE IN FAVOUR OF THE NEUTRAL START HYPOTHESIS

In this paper, we argue that the trochaic bias, first proposed by Allen & Hawkins (1978, 1980), should be eliminated from phonological theory. First, we demonstrate that the cross-linguistic evidence supporting this construct is far from conclusive. Second, we discuss the fact that babbling and early acquisition data do not provide any independent proof for such a grammatical bias in phonological development. Finally, even in situations where everything is in place to favour the manifestation of a bias towards trochaic footing, no convincing evidence can be found to support the presence of this bias. We begin by providing an overview of the predictions made by the trochaic bias as well as a brief survey of the relevant literature in the context of child language phonology. Building on this discussion, we introduce the current study, based on acoustic data from a bilingual English-French child. As we will see, the data from this child also fail to provide any support for the trochaic bias. We conclude with a brief summary and discussion supporting the Neutral Start Hypothesis (e.g. Klein 1984, Hochberg 1988), according to which no innate bias favours any kind of foot form in language development.
Studies on integrated nutrient management in pearl millet-Indian mustard cropping system

The main objective was to find out the suitable dose of integrated nutrients for pearl millet and Indian mustard under pearl millet-Indian mustard cropping system. The pooled results of three years displayed that the direct application of FYM, @ 5 t + N 60 kg + P 40 kg + K 30 kg ha with residue of N 150 kg + P 75 kg + K 30 kg + gypsum 200 kg + ZnSo 4 10 kg + FeSo 4 10 kg ha gave significantly higher grain yield of pearl millet (3288 kg ha). The lowest grain yield of pearl millet recorded at control (2082 kg ha). Significantly maximum seed yield of Indian mustard was recorded at direct application of N 150 kg + P 75 kg + K 30 kg + gypsum 200 kg + ZnSo 4 10 kg + FeSo 4 10 kg ha and residue of FYM @ 5 t + N 60 kg + P 40 kg + K 30 kg ha -, left by pearl millet (1745 kg ha), while lowest yield noted at control. The growth and yield traits of both the crops were concordant to the yields obtained from pearl millet-Indian mustard cropping system. The direct application of FYM @ 5 t + N 60 kg + P 40 kg + K 30 kg ha to pearl millet and N 150 kg + P 75 kg + K 30 kg + gypsum 200 kg + ZnSo 4 10 kg + FeSo 4 10 kg ha to Indian mustard under sequential cropping gave significantly higher pearl millet equivalent yield (9718 kg ha), net return (Rs. 50050 ha), link relative index (5.35) and BCR (1:2.67) in comparison to other tested nutrients combination.
Assessing Perceived Marriage Education Needs and Interests of Latino Individuals in Utah County, Utah

ASSESSING PERCEIVED MARRIAGE EDUCATION NEEDS AND INTERESTS OF LATINO INDIVIDUALS IN UTAH COUNTY, UTAH Iliana Baltazar Snyder Marriage and Family Therapy Master of Science This study utilized focus groups to assess the perceived needs and interests for marriage education among single and married Latino individuals residing in Utah County, Utah as well as the identification of common themes and differences for this population. Male and female groups at various points in the marital developmental life stage were studied including high school students (15-18 years of age), single never married young adults (19-30 years of age), committed (engaged or cohabiting) adults, married persons recently transitioning to parenting, and married people with children. The sample consisted of 10 groups, 5 female and 5 male. In addition, a professional group consisting of professionals who are in daily contact with the Latino population also participated (N=12). A total of 53 Latino individuals and 12 professionals were interviewed in the focus groups. The participants were asked 14 open-ended questions to assess various elements of marriage education including content, cost, convenient locations, sources of information, perceived barriers to getting services as well as strategies on how to get people involved in marriage education programs. The data from the focus groups were analyzed using inductive qualitative methods. The findings showed that most females were concerned about domestic violence and infidelity as topics in marriage education while males were more concerned about having financial stability, improving communication skills and increase their parenting skills. These results support the importance of conducting focus groups as a way to assess marriage education needs and interests of the Latino population. Limitations for future research are discussed, implications for marriage education programming for Latino couples as well as implications for marriage and family therapists.