Miracle-dz/UniFAR-FTUs huggingface dataset:
Towards Diagrammatic Ontology Patterns

It has long been recognized that patterns can be a useful and important tool when building models. This is reflected by their adoption in the practice of ontology and software engineering. Similarly, visual representations of information are often seen as beneficial with, for example, software engineering making use of the suite of diagrammatic notations forming the UML. Likewise, ontology engineering has seen the development of a variety of different visualizations for classes and properties. This paper combines these two strands of work, making visual (diagrammatic) patterns available to ontology engineers.
Effects of school-based aerobic exercise on blood pressure in adolescent girls at risk for hypertension.

OBJECTIVES This study evaluated the effects of aerobic exercise physical education on blood pressure in high-risk, predominantly African-American, adolescent girls. METHODS Ninth-grade girls (n = 99) with blood pressure above the 67th percentile were randomized to 1 semester of aerobic exercise classes or standard physical education classes. RESULT The study was completed by 88 girls. At posttest, only members of the aerobic exercise group increased their estimated cardiorespiratory fitness. The aerobic exercise group had a greater decrease in systolic blood pressure than the standard physical education group (P < .03). CONCLUSIONS Aerobic exercise physical education is a feasible and effective health promotion strategy for high-risk adolescent girls.
Characterization of the Dynamical Processes in All-Optical Signal Processing Using Semiconductor Optical Amplifiers

We present experimental investigations of the dynamical properties of semiconductor optical amplifiers (SOAs) and their impacts in all-optical signal processing using SOAs. We introduce ultrafast optical signal characterization techniques to fully characterize the gain and phase dynamics of SOAs. We elucidate a consequence of the slow carrier recovery as pattern-dependent phase fluctuation in wavelength conversion of on-off -keyed signals. We also analyze the conversion of the phase fluctuation into amplitude fluctuation limiting the performance of all-optical xor operation. Finally, the performance of all-optical wavelength conversion of differential phase-shift-keyed signals is presented with emphasis on regeneration of the phase information.
Validating the Western Trauma Association algorithm for managing patients with anterior abdominal stab wounds: a Western Trauma Association multicenter trial.

UNLABELLED The optimal management of stable patients with anterior abdominal stab wounds (AASWs) remains a matter of debate. A recent Western Trauma Association (WTA) multicenter trial found that exclusion of peritoneal penetration by local wound exploration (LWE) allowed immediate discharge (D/C) of 41% of patients with AASWs. Performance of computed tomography (CT) scanning or diagnostic peritoneal lavage (DPL) did not improve the D/C rate; however, these tests led to nontherapeutic (NONTHER) laparotomy (LAP) in 24% and 31% of cases, respectively. An algorithm was proposed that included LWE, followed by either D/C or admission for serial clinical assessments, without further imaging or invasive testing. The purpose of this study was to evaluate the safety and efficacy of the algorithm in providing timely interventions for significant injuries. METHODS A multicenter, institutional review board-approved study enrolled patients with AASWs. Management was guided by the WTA AASW algorithm. Data on the presentation, evaluation, and clinical course were recorded prospectively. RESULTS Two hundred twenty-two patients (94% men, age, 34.7 years ± 0.3 years) were enrolled. Sixty-two (28%) had immediate LAP, of which 87% were therapeutic (THER). Three (1%) died and the mean length of stay (LOS) was 6.9 days. One hundred sixty patients were stable and asymptomatic, and 81 of them (51%) were managed entirely per protocol. Twenty (25%) were D/C'ed from the emergency department after (-) LWE, and 11 (14%) were taken to the operating room (OR) for LAP when their clinical condition changed. Two (2%) of the protocol group underwent NONTHER LAP, and no patient experienced morbidity or mortality related to delay in treatment. Seventy-nine (49%) patients had deviations from protocol. There were 47 CT scans, 11 DPLs, and 9 laparoscopic explorations performed. In addition to the laparoscopic procedures, 38 (48%) patients were taken to the OR based on test results rather than a change in the patient's clinical condition; 17 (45%) of these patients had a NONTHER LAP. Eighteen (23%) patients were D/C'ed from the emergency department. The LOS was no different among patients who had immediate or delayed LAP. Mean LOS after NONTHER LAP was 3.6 days ± 0.8 days. CONCLUSIONS The WTA proposed algorithm is designed for cost-effectiveness. Serial clinical assessments can be performed without the added expense of CT, DPL, or laparoscopy. Patients requiring LAP generally manifest early in their course, and there does not appear to be any morbidity related to a delay to OR. These data validate this approach and should be confirmed in a larger number of patients to more convincingly evaluate the algorithm's safety and cost-effectiveness compared with other approaches.
[Study on the molecular mechanisms involved in the increased collagen synthesis by platelet-derived wound healing factors during wound healing in alloxan-induced diabetic rat].

OBJECTIVE To explore the molecular mechanisms involved in the increased collagen synthesis by platelet-derived wound healing factors (PDWHF) during wound healing in alloxan-induced diabetic rats. METHODS Thirty-three male SD rats were divided into two groups, the normal (n = 9) (group A) and the diabetic group (n = 24). Two pieces of full-thickness skin with diameter of 1.8 cm were removed from the dorsal site of diabetic rats. PDWHF (100 micrograms/wound) was topically applied to one side of the diabetic wounds (group B) on the operation day and then once a day in the next successive 6 days. Meanwhile, bovine serum albumin (100 micrograms/wound) was applied to the other side of diabetic wound as control group (group C) in the same way. Levels of transforming growth factor-beta 1 (TGF-beta 1) and procollagen I mRNA in wound tissue were inspected by dot blotting. RESULTS TGF-beta 1 mRNA levels in group B were 4 folds and 5.6 folds compared with those in group C after 5 and 7 days (P < 0.01), however, still significantly lower than those of group A (P < 0.05). There was no significance difference among three groups on the 10th day after wounding. The levels for procollagen I mRNA in group B amounted to 2.1, 1.8 and 2.3 folds of those in group C after 5, 7, and 10 days (P < 0.01), respectively. Compared with those in the group A, procollagen I mRNA levels in the group B were significantly lower after 5 and 7 days (P < 0.05), and no significant difference was observed between group B and A after 10 days. CONCLUSION One important way for PDWHF to enhance the collagen synthesis in diabetic wound healing is to increase the gene expression of endogenous TGF-beta 1.
Liver Transplantation for Hepatocellular Carcinoma: Beyond the Milan Criteria

Liver transplantation represents a cornerstone in the management of early‐stage hepatocellular carcinoma (HCC). Expansion beyond the Milan criteria for liver transplantation (1 lesion ≤ 5 cm, or 2 to 3 lesions each ≤ 3 cm) remains controversial. This review covers several key areas: (1) Recent developments and published data on expanded criteria for deceased donor and live‐donor liver transplantation, with emphasis on criteria that have been applied to preoperative imaging. (2) Independent testing of expanded criteria, where published data are largely limited to the proposed University of California, San Francisco criteria (1 lesion ≤ 6.5 cm, 2–3 lesions each ≤ 4.5 cm with total tumor diameter ≤ 8 cm). (3) Response to loco‐regional therapy and tumor downstaging. (4) The fundamental questions and answers in resolving the controversy over expanded criteria. The key issue pertains to whether acceptable outcome can be achieved on a broader scale beyond single center experience, which appears to support modest expansion beyond the Milan criteria. The foundation of the debate over expanded criteria may rest upon what the transplant community would consider to be the acceptable threshold for patient survival using expanded criteria, without causing significant harm to other transplant candidates without HCC.
Regeneration of ciliary comb plates in the ctenophore Mnemiopsis leidyi. i. morphology

Regeneration of missing body parts in model organisms provides information on the mechanisms underlying the regeneration process. The aim here is to use ctenophores to investigate regeneration of their giant ciliary swimming plates. When part of a row of comb plates on Mnemiopsis is excised, the wound closes and heals, greatly increasing the distance between comb plates near the former cut edges. Video differential interference contrast (DIC) microscopy of the regeneration of new comb plates between widely separated plates shows localized widenings of the interplate ciliated groove (ICG) first, followed by growth of two opposing groups of comb plate cilia on either side. The split parts of a new plate elongate as their bases extend laterally away from the ICG widening and continue ciliogenesis at both ends. The split parts of a new plate grow longer and move closer together into the ICG widening until they merge into a single plate that interrupts the ICG in a normal manner. Video DIC snapshots of dissected gap preparations 1.5–3‐day postoperation show that ICG widenings and/or new plates do not all appear at the same time or with uniform spacing within a gap: the lengths and distances between young plates in a gap are quite variable. Video stereo microscopy of intact animals 3–4 days after the operation show that all the new plates that will form in a gap are present, fairly evenly spaced and similar in length, but smaller and closer together than normal. Normal development of comb plates in embryos and growing animals is compared to the pattern of comb plate regeneration in adults. Comb plate regeneration differs in the cydippid Pleurobrachia that lacks ICGs and has a firmer mesoglea than Mnemiopsis. This study provides a morphological foundation for histological, cellular, and molecular analysis of ciliary regeneration in ctenophores. J. Morphol. 2011. © 2011 Wiley Periodicals, Inc.
Position of fixed‐dose combinations containing an AT1‐receptor blocker and a thiazide diuretic

Treatment of hypertension remains a difficult task despite the availability of different types of medications lowering blood pressure by different mechanisms. In order to reach the target blood pressures recommended today combination therapy is required in most patients. The co‐administration of two drugs with different impacts on the cardiovascular system markedly increases the antihypertensive effectiveness without altering adversely tolerability. Fixed low‐dose combinations are becoming a valuable option not only as second‐line, but also as first‐line therapy. In this respect the co‐administration of thiazide diuretic with an AT1‐receptor blocker is particularly appealing. The diuretic‐induced decrease in total body sodium activates the renin–angiotensin system, thus rendering blood pressure maintenance angiotensin II‐dependent. During blockade of the renin–angiotensin system low doses of thiazides generally suffice, allowing the prevention of undesirable metabolic effects. Also, blockade of the AT1‐receptor, particularly when angiotensin II production is enhanced in response to diuretic therapy, is expected to be beneficial, since angiotensin II seems to contribute importantly to the pathogenesis of cardiovascular and renal complications of hypertension.
Data characterization for automatically visualizing heterogeneous information

Automated graphical generation systems should be able to design effective presentations for heterogeneous (quantitative and qualitative) information in static or interactive environments. When building such a system, it is important to thoroughly understand the presentation-related characteristics of domain-specific information. We define a data-analysis taxonomy that can be used to characterize heterogeneous information. In addition to capturing the presentation-related properties of data, our characterization takes into account the user's information-seeking goals and visual-interpretation preferences. We use automatically-generated examples from two different application domains to demonstrate the coverage of the proposed taxonomy and its utility for selecting effective graphical techniques.
Distant horizons.

JUGGLING THE conflicting demands of a busy career with the responsibilities of family life can often leave little time for study. However, according to the RCN Institute's head of distance learning, Liz Clark, that's one of the major reasons why this form of post-registration education is proving to be so popular with nurses.
Low Upper Limit to Methane Abundance on Mars

No Methane to Be Found On Earth, atmospheric methane is mostly produced biologically. Atmospheric methane has also been detected on Mars, but these reports have been controversial. Based on data from the Sample Analysis at Mars instrument suite on the Curiosity rover, which arrived at the surface of Mars in August 2012, Webster et al. (p. 355, published online 19 September) report no methane, with an upper limit of only 1.3 parts per billion by volume, about 6 times lower than previous measurements. Data from the Curiosity rover reveal an upper limit on Mars of only 1.3 parts per billion by volume for atmospheric methane. By analogy with Earth, methane in the Martian atmosphere is a potential signature of ongoing or past biological activity. During the past decade, Earth-based telescopic observations reported “plumes” of methane of tens of parts per billion by volume (ppbv), and those from Mars orbit showed localized patches, prompting speculation of sources from subsurface bacteria or nonbiological sources. From in situ measurements made with the Tunable Laser Spectrometer (TLS) on Curiosity using a distinctive spectral pattern specific to methane, we report no detection of atmospheric methane with a measured value of 0.18 ± 0.67 ppbv corresponding to an upper limit of only 1.3 ppbv (95% confidence level), which reduces the probability of current methanogenic microbial activity on Mars and limits the recent contribution from extraplanetary and geologic sources.
Precision simulation of ground-based lensing data using observations from space

Current and upcoming wide-field, ground-based, broad-band imaging surveys promise to address a wide range of outstanding problems in galaxy formation and cosmology. Several such uses of ground-based data, especially weak gravitational lensing, require highly precise measurements of galaxy image statistics with careful correction for the effects of the point spread function (PSF). In this paper, we introduce the shera (SHEar Reconvolution Analysis) software to simulate ground-based imaging data with realistic galaxy morphologies and observing conditions, starting from space-based data (from the Cosmological Evolution Survey, COSMOS) and accounting for the effects of the space-based PSF. This code simulates ground-based data, optionally with a weak lensing shear applied, in a model-independent way using a general Fourier space formalism. The utility of this pipeline is that it allows for a precise, realistic assessment of systematic errors due to the method of data processing, for example in extracting weak lensing galaxy shape measurements or galaxy radial profiles, given user-supplied observational conditions and real galaxy morphologies. Moreover, the simulations allow for the empirical test of error estimates and determination of parameter degeneracies, via generation of many noise maps. The public release of this software, along with a large sample of cleaned COSMOS galaxy images (corrected for charge transfer inefficiency), should enable upcoming ground-based imaging surveys to achieve their potential in the areas of precision weak lensing analysis, galaxy profile measurement and other applications involving detailed image analysis.
Dags in sheep; a look at faeces and reasons for dag formation

Dags represent a major cost to sheep farmers, in both monetary terms and because of the stress associated with flystrike. Historically, the incidence of dags has been attributed in large part to worm burdens, but other causes may be more important, viz parasite larval challenge, fungal endophyte and selection of sheep for resistance to worms. These and other factors associated with the incidence of dags are summarised, together with variations in faecal types (physical and chemical composition) which affect their capacity for adhesion to wool. Much of these data emphasise the importance of differences or changes in intestinal function being responsible for the loose and gooey faeces which develop into dags. Flystrike is strongly correlated with dags, and this scenario cannot be tolerated in a country claiming to produce good, clean food.
Factors associated with primary care prescription of opioids for joint pain

Opioids are commonly prescribed in primary care and can offer pain relief but may also have adverse effects. Little is known about the characteristics of people likely to receive an opioid prescription in primary care. The aim is to identify what factors are associated with primary care prescribing of high‐strength analgesics in a community sample of older people with joint pain.
Eliminating barriers to personalized medicine

With the emergence of high-throughput discovery platforms, robust preclinical small-animal models, and efficient clinical trial pipelines, it is becoming possible to envision a time when the treatment of human neurologic diseases will become personalized. The emergence of precision medicine will require the identification of subgroups of patients most likely to respond to specific biologically based therapies. This stratification only becomes possible when the determinants that contribute to disease heterogeneity become more fully elucidated. This review discusses the defining factors that underlie disease heterogeneity relevant to the potential for individualized brain tumor (optic pathway glioma) treatments arising in the common single-gene cancer predisposition syndrome, neurofibromatosis type 1 (NF1). In this regard, NF1 is posited as a model genetic condition to establish a workable paradigm for actualizing precision therapeutics for other neurologic disorders.
Neurological and psychosocial outcome 4 to 7 years after subarachnoid hemorrhage.

OBJECTIVE Previous studies have demonstrated that many patients with good neurological outcomes still experience excessive fatigue, cognitive impairments, and lowered work status 1 year after subarachnoid hemorrhage (SAH). Does recovery continue for many years or are survivors of SAH left with permanent disabilities? We describe the long-term outcome. METHODS Approximately 50% (n = 123) of the patients who survived SAH for more than 3 years from a population of 1.5 million and who had participated in research studies at the time of their SAH were interviewed 4 to 7 years later by telephone or questionnaire. Participants did not differ from the 126 unsurveyed survivors in age, gender, SAH grades, aneurysm sites, or complications. RESULTS Most patients thought their recovery to be satisfactory to good, although some reported memory problems (41%), headaches (16.5%), daytime sleepiness (35%), problems sleeping at night (26%), a reduced ability to work (20%), and a changed personality (48.3%). Many had reduced their smoking and drinking. Each of 24 of the 121 participants for whom seizure data were available (all with clipped aneurysms) had suffered at least one seizure, but only each of 10 had suffered two or more seizures since hospital discharge. Relative youth was the only significant predictor of seizures, with strong trends observed between seizures and a poor Glasgow Outcome Scale score at 10 weeks or between seizures and an ischemic neurological deficit. No evidence for the effectiveness of prophylactic anticonvulsants was demonstrated. CONCLUSION Survivors of SAH continue to recover for years and develop good coping skills and a positive attitude toward their recovery, even when they experience ongoing problems. Few are left with disabling headaches or epilepsy.
Healing of Subacute Tympanic Membrane Perforations in Chinchillas Treated with Epidermal Growth Factor and Pentoxifylline

Hypothesis: The aims of the present study were to determine the effect of epidermal growth factor (EGF) and pentoxifylline on subacute tympanic membrane (TM) perforations and to quantify the healing rate of such perforations treated with these drugs alone or in combination. Background: It is known that EGF modulates in vitro and in vivo proliferation of epithelial and endothelial cells. Pentoxifylline is a methylxanthine that has been used to treat experimental skin flaps and venous leg ulcers. Data in the literature regarding this subject are contradictory, and quantitative data regarding the effects of EGF and pentoxifylline on TM perforation healing are scarce. Methods: We studied 50 chinchillas submitted to TM perforation. On postoperative Day 30, eight were selected for histologic analysis. Of the remaining 42, those presenting little or no healing were distributed into four groups: control, EGF, pentoxifylline, and EGF combined with pentoxifylline. Results: Histologic analysis showed that the observation period adopted was sufficient to consider the TM perforations subacute. We found significant differences between the study groups and the control group in the healing rate of subacute TM perforations during a 30-day period (analysis of variance; p < 0.001), which was 30.3% for the EGF group, 3.6% for the pentoxifylline group, 16.5% for the EGF-pentoxifylline group, and 8.7% for the control group. Conclusions: The use of EGF promoted healing of subacute TM perforations in chinchillas, and the use of pentoxifylline did not. The combination of the two had no synergistic effect on the healing of these perforations.