Miracle-dz/UniFAR-FTUs huggingface dataset:
PDGF and TGF-α Act Synergistically to Improve Wound Healing in the Genetically Diabetic Mouse

Impaired wound healing results in significant morbidity for the surgical patient. The genetically diabetic (C57BL/KsJ-db/db) mouse is obese, hyperglycemic, insulin-resistant, and exhibits markedly impaired wound healing. Previous studies have demonstrated that the fibroblast mitogens, BB homodimer of platelet-derived growth factor (PDGF-BB) or basic fibroblast growth factor, plus insulin-like growth factor, act synergistically to enhance wound closure in the genetically diabetic mouse. The purpose of this study was to determine whether the keratinocyte mitogens, epidermal growth factor (EGF) or transforming growth factor-alpha (TGF-alpha), in combination with the fibroblast mitogen, PDGF-BB, would produce a similar synergistic enhancement in tissue repair. Full-thickness skin wounds created on the backs of diabetic mice received topical applications of vehicle (5% polyethylene glycol), PDGF-BB (10 micrograms), EGF (1 microgram), TGF-alpha (1 microgram), or the combination of PDGF (10 micrograms) and EGF (1 microgram) or TGF-alpha (1 microgram) for 5 consecutive days starting at wounding. Application of PDGF-BB or TGF-alpha alone to wounds in diabetic animals improved wound closure when compared to vehicle treatment. EGF did not affect healing and did not have any additive effects when combined with PDGF-BB. Significant improvements in wound closure were observed with the combination of PDGF-BB and TGF-alpha when compared to treatment with the individual growth factors. The PDGF-BB/TGF-alpha combination accelerated healing in the diabetic animals to a rate that was closer to that seen in nondiabetic mice. (ABSTRACT TRUNCATED AT 250 WORDS)
Running head: RATIONAL ANALYSIS OF CURIOSITY 1 Reconciling Novelty and Complexity through a Rational Analysis of Curiosity

Curiosity is considered to be the essence of science and an integral component of cognition. What prompts curiosity in a learner? Previous theoretical accounts of curiosity remain divided – novelty-based theories propose that new and highly uncertain stimuli pique curiosity whereas complexity-based theories propose that stimuli with an intermediate degree of uncertainty stimulate curiosity. In this article, we present a rational analysis of curiosity by considering the computational problem underlying curiosity, which allows us to model these distinct accounts of curiosity in a common framework. Our approach posits that a rational agent should explore stimuli that maximally increase the usefulness of its knowledge and that curiosity is the mechanism by which humans approximate this rational behavior. Critically, our analysis show that the causal structure of the environment can determine whether curiosity is driven by either highly uncertain or moderately uncertain stimuli. This suggests that previous theories need not be in contention but are special cases of a more general account of curiosity. Experimental results confirm our predictions and demonstrate that our theory explains a wide range of findings about human curiosity, including its subjectivity and malleability.
Support Fund 11-8-2018 Gaslighting , Cofabulation , and Epistemic Innocence

Recent literature on epistemic innocence develops the idea that a defective cognitive process may nevertheless merit special consideration insofar as it confers an epistemic benefit that would not otherwise be available. For example, confabulation may be epistemically innocent when it makes a subject more likely to form future true beliefs or helps her maintain a coherent self-concept. I consider the role of confabulation in typical cases of interpersonal gaslighting, and argue that confabulation will not be epistemically innocent in such cases even if it does preserve a coherent self-concept or belief-set for the subject. Analyzing the role of confabulation in gaslighting illustrates its role in on-going interpersonal relationships, and augments already growing evidence that confabulation may be quite widespread. The role of confabulation in gaslighting shows that whether confabulation confers epistemic benefits (and so is epistemically innocent) will depend greatly on the interpersonal context in which it is deployed, while whether a coherent self-concept is epistemically beneficial will depend to a great extent on the content of that self-concept. This shows that the notion of an epistemically harmful or beneficial feature of a cognitive process can and should be further clarified, and that doing so has both theoretical and practical advantages in understanding epistemic innocence itself.
Isokinetic strength effects of FIFA's "The 11+" injury prevention training programme

The purpose of this study was to evaluate whether FIFA's Med ical Assessment and Research Centre (F-MARC) injury prevention programme, "The 11+", improves isokinetic strength of the knee extensor and flexor muscles in sub-elite socc er players. Twenty players aged 22.3 ± 4.2 yr performed "The 11+" 3 times a week for 10 weeks. Isokinetic measurements were performed on the hamstrings and quadriceps muscles on both lower extremities at concentric 60 and 180 � /s and eccentric 30 � /s. The peak torque (PT) as well as conventional and dynamic control ratios (DCR) were calculated. Hamstrings PT in the non-dominant limb increased by 14.6%, 15.0% and 14.3% during the above contractions/velocities, respectively ( p < 0.05). In the dominant limb the concentric PT of the quadriceps increased by 6.9% (60 � /s) and 8.3% (180 � /s) whereas that of the hamstring increased by 20.4% (60 � /s), (p < 0.05). The training programme significantly improved the co nventional H/Q ratio at 60 � /s by 14.8% and the DCR by 13.8% in the non-dominant limb (p < 0.05). Therefore, the "The 11+" training programme appears to be adequate and effective for soccer training and conditioning by improving strength and muscle balance around the knee joint.
Towards a Unified Model of Spatial Computing

In spatial computing, there is a fundamental tension between discrete and continuous models of computation: computational devices are generally discrete, yet it is often useful to program them in terms of the continuous environment through which they are embedded. Aggregate programming models for spatial computers have attempted to resolve this tension in a variety of different ways, generating a profusion of approaches that are difficult to compare or combine. Recently, however, two minimal models have been proposed: continuous space-time universality and a discrete field calculus. This paper unifies these two models by proving that field calculus is space-time universal, and thus provides the first formal connection between continuous and discrete approaches to spatial computing.
Roles of Physical , Pedagogical Environment and Leadership Practices toward Humanizing Education : Teachers ’ Views 1

It is considered that modern education is designed to shape students like lifeless physical objects. It is also accepted that the art of teaching as filling students with knowledge like filling a bottle from a tap. Ultimately, this kind of education ignores basic human values and solidarity among them, whereas students need to determine their own ways in their nature. In this respect, during educational practices; physical, pedagogical environment and leadership practices may play important roles to settle values among students. Therefore, this qualitative study purposed to explore teachers’ views on roles of physical and pedagogical environment and administrators’ leadership practices toward humanizing education. Results revealed that physical and pedagogical learning environments were not designed to make educational processes more humanized. Also, administrators’ leadership practices do not serve education to become more humanized. It is recommended that while designing and managing educational processes, human factor should be in the center.
Whence Cultural Rituals ? A Cultural Selection Model of Ritualized Behavior

We propose a neuro-cognitive model of the recurrent features of Ritualized Behavior (stereotypy, rigidity in performance, sense of urgency) and the recurrent themes of collective rituals (potential danger from contamination, predation, social hazard). This can only be explained if we consider the broader domain of ritualized behaviour, present in childhood rituals, obsessive-compulsive patho logy and in normal intrusive thoughts or compulsions in adults. On the basis of neuro-cognitive models of clinical and non-clinical individual ritualization, we describe the implication of a Hazard-Precaution system, specialized in the detection of and response to potential threats to fitness. Collective rituals include description of potential hazards and prescriptions for actions that closely match those engaged in security motivation. Indeed, compulsive pathologies and collective rituals are so similar in both themes (contamination, social hazard) and organization (ritualization). In our selectionist model, action-prescriptions that match the input conditions for security systems thereby become highly attention-demanding and intuitively compelling, which contributes to their transmission from place to place or generation to generation. We explore empirical consequences for the study of col-
An Empirical Analysis of the Effect of Behavioral Quality Management on the Relationship between Technical Quality Management and Firm Performance

This study aims to investigate the relationships between behavioral quality management (QM), technical QM, and firm performance. A survey research and structural equation modeling analysis were conducted to test the hypothesized research model of this study. The study results represent that there is a full mediation effect of behavioral QM on the relationship between technical QM and firm performance. Implications were discussed in terms of the resource-based view.
Akademia Baru The Relationship between Corporate Social Responsibility and Financial Performance : A Literature Review

Corporate social responsibility (CSR) concept has been widely understood. Organizations should not only pledge on their economic consequences but environmental and social implications as well. CSR value has been attained interest among practitioners, most of them are eager to ascertain if the social responsibility can elevate its financial performance. Anyhow, heterogeneous results and contrary between analysis data has been observed. This paper’s objective is to identify the relationship between CSR and financial performance. It contains the integration of literature review between years 2011 to 2015 from the academics and researchers relating to the CSR and financial performance. Despite from the main variables, other factors such as the mediating variables, the approach applied, the methodology techniques and the industries involved are being discussed. This paper draws a link between CSR and corporate financial performance more deeply through the literature reviews analysis. The segregation of the literature review is presumed to have the comprehensiveness added for the future studies. The findings appeared to be consistence where CSR has a positive relationship to the financial performance. It validated the worth for an organization’s efforts to apply CSR. Additionally, this study provides greater insights for future researchers to scrutinize in more specific area that will help to groom CSR in the industry. Copyright © 2015 Penerbit Akademia Baru All rights reserved.
ECNet : Early Attention and Local Convolution for Machine Comprehension

Current state-of-the-art machine comprehension models have some common tenets. One, the use of an embedding encoder layer to exploit contextual cues from surrounding words. Two, the use of neural attention mechanisms to exploit matching cues between the context and the query. In this paper we propose ECNet, a hierarchical model for machine comprehension, which amplifies existing models by adding early attention and local convolution. It uses self-attention over the input embeddings as a form of early attention. For the embedding encoder layer, ECNet models both sequential and local interactions between words, using recurrent and convolution layers respectively and combining them. On the SQuAD 2.0 dataset, ECNet outperforms the BiDAF model proposed recently in literature.
Virulence of Vibrio harveyi possessing a transferable chloramphenicol resistance determinant to larvae of Indian white shrimp Fenneropenaeus indicus ( Decapoda )

The virulence of luminous Vibrio harveyi possessing a transferable chloramphenicol-resistance determinant to Indian white shrimp, Fenneropenaeus indicus larvae was studied. The V. harveyi strains isolated from luminous F. indicus larvae produced extracellular virulence factors such as haemolysin, chitinase, proteinase, lipase and phospholipase were resistant to at least four of six antibiotics tested. The chloramphenicol-resistance determinant was transferred from V. harveyi to Escherichia coli at frequencies of 6.69 × 10 4.27 × 10. The concentration of V. harveyi cells capable of causing 50% mortality differed significantly (P<0.05) and the 72 h LD50 values ranged between 273 and 3,040 cells/ml. The chloramphenicol-resistant strains were more virulent to shrimp larvae compared to chloramphenicol-sensitive strain. Prevalence of highly virulent V. harveyi strains harbouring a transferable chloramphenicol-resistance determinant together with other extracellular virulence factors may hamper the hatchery production of penaeid shrimp larvae.
Measuring disagreement in science

Dispute in science is central to the production of new knowledge. Such disputes leave traces in scholarly documents, generally through the form that is taken by citations. Based on the full text of scholarly papers from the Elsevier ScienceDirect database published between 1980 and 2016, this paper develops a methodology for investigating disagreement in science. Several signal phrases of disagreement are tested, and two are used (“contradict” and “conflict”, with the filter phrases “studies” or “results”) to assess the prevalence of disagreement across position within a paper and across disciplines. Results show that disagreement is relatively more common in the introduction and discussion sections of papers, as well as in fields of biomedical sciences, health sciences, social sciences, and humanities.
Association between early childhood caries and oral health-related quality of life using ecohis instrument

Dental caries is an oral health problem that can develop early in preschool children, affecting their quality of life. The objective of this study was to assess the relationship between caries status and oral health-related quality of life (OHRQoL) in preschool children at Grogol Utara, Kebayoran Lama, Jakarta Selatan. We conducted a cross-sectional study on 200 children aged 3–5 years. Dental caries status was assessed via clinical examination. OHRQoL was assessed using the Early Childhood Oral Health Impact Scale (ECOHIS) by interviewing a total of 165 mothers. The results of the ECOHIS were used to represent the OHRQoL. A significant difference was seen between caries status and OHRQoL regarding the impact on both children and their families (P<.05). In addition, there was a significant difference between caries free and severe early childhood caries in all domains except the self-image/social interaction domain and the overall ECOHIS score (P<.05). We found no significant difference between caries free and early childhood caries in all domains and overall ECOHIS score (P≥0.05). Caries severity in preschool children had a negative impact on the OHRQoL of the children and their families. Clinical article (J Int Dent Med Res 2019; 12(3): 1017-1021)
Situación de la mortalidad materna en el Perú, 2000 - 2012

We perform an analysis concerning the situation of maternal mortality in Peru, based on the information of the System of Epidemiologic Surveillance of Maternal Mortality of the General Directorate of Epidemiology of the Ministry of Health and the Family and Health Demographic Survey. We can see a decrease in the rates of maternal mortality between 2000 and 2012. The direct causes are the same but in different proportions according to the natural regions, being the hemorrhage the first cause of maternal mortality. The coverage of birth attention in health establishments has increased in the last years but it is still necessary to improve the capacity of quick response and the quality of the health services. Maternal mortality in Peru is related to inequity and lack of women empowerment to excerpt their rights, specially the sexual and reproductive rights. It is necessary to strengthen the strategies that have been implemented in order to accomplish of the reduction in maternal mortality in Peru.
Response to Comment by Reviewer # 1 1 General Comments

Herman (2010) modeled the FSD as a generalized Lotka-Volterra system, which admits as a solution a Pareto distribution of floe sizes, and suggested that this distribution might fit observed FSDs. Toyota et al. (2011) showed that observed FSDs in the Weddell Sea may be fit by a power law and, that such a scaling relationship may be obtained by assuming that ice fracture is a self-similar process, following a renormalization group method.
THE FOLK MODEL CATEGORY STRUCTURE ON STRICT ω-CATEGORIES IS MONOIDAL by

— We prove that the folk model category structure on the category of strict ω-categories, introduced by Lafont, Métayer and Worytkiewicz, is monoidal, first, for the Gray tensor product and, second, for the join of ω-categories, introduced by the first author and Maltsiniotis. We moreover show that the Gray tensor product induces, by adjunction, a tensor product of strict (m, n)-categories and that this tensor product is also compatible with the folk model category structure. In particular, we get a monoidal model category structure on the category of strict ω-groupoids. We prove that this monoidal model category structure satisfies the monoid axiom, so that the category of Gray monoids, studied by the second author, bears a natural model category structure. Introduction The category ω-Cat of strict ω-categories, that we shall simply call ω-categories in this paper, is endowed with a model category structure, introduced by Lafont, Métayer and Worytkiewicz [15], known as the folk model category structure. The weak equivalences of this structure are the equivalences of ω-categories, higher dimensional generalization of the equivalences of categories or of 2-categories; the cofibrant objects are the ω-categories that are free in the sense of polygraphs [17]. This model category structure, which is also called the canonical model category structure, is in some sense intrinsic to the notion of ω-categories. On the other hand, the category ω-Cat is endowed with two non-trivial monoidal category structures. The first one is the Gray tensor product ⊗, sometimes called the lax Gray tensor product, first introduced by Al-Agl and Steiner [1], and then studied by Crans [5]. This tensor product generalizes the tensor product of 2-categories 2020 Mathematics Subject Classification. — 18M05, 18N30, 18N40, 55U35.
Upper Cretaceous bivalves from Tercis , Landes , SW France

From Upper Campanian and Maastrichtian strata from Tercis (Landes, France) twenty four inoceramid taxa have been recognized. In the lower Upper Campanian they have a strong similarity with faunas from Westphalia and from the area around Aachen, but in younger outcrops the affinities are mainly with faunas from the northern Tethys margin. Key-words: Mollusca, Bivalvia, inoceramids, Cretaceous, Taxonomy, Biostratigraphy.
ITS 2 variability of Biomphalaria ( Mollusca , Planorbidae ) species from the Paranapanema Valley ( São Paulo State , Brazil ) : Diversity patterns , population structure , and phylogenetic relationships

The ribosomal DNA internal transcribed spacer 2 (ITS2) has been shown to be a useful genetic marker for species identification and phylogenetic reconstruction in the genus of freshwater snails Biomphalaria (Preston 1910). Additionally, ITS2 studies in Biomphalaria have uncovered significant intra-specific genetic variability suggesting the presence of cryptic species complexes. We obtained ITS2 sequences for the Biomphalaria species B. glabrata, B. tenagophila, B. occidentalis and B. peregrina from the Paranapanema Valley (São Paulo State, Brazil) and compared them with a comprehensive set of published Biomphalaria ITS2 sequences using Bayesian inference of phylogeny. Analysis of the resulting trees showed that the newly obtained B. glabrata sequences did not cluster with those from other Brazilian localities and that sub-structuring occurred among Brazilian B. tenagophila populations. Moreover, although ITS2 sequences seem to indicate clear genetic differentiation within both B. glabrata and B. tenagophila, evidence in support of the occurrence of cryptic species is more compelling for the latter. We discuss the significance and implications of the detected patterns of ITS2 variability for taxonomic studies in Biomphalaria.
Spring 5-2019 PREDICTORS OF ON-TREATMENT MORTALITY OF PATIENTS UNDERGOING PALLIATIVE RADIATION THERAPY : IMPROVING THE QUALITY OF END-OFLIFE CANCER CARE

PURPOSE: Excessive medical treatment at end-of-life is an indicator of poor quality care. While radiation therapy (RT) is effective for palliation, some patients die shortly after or even during treatment. Any treatment that requires terminal patients to spend significant time in the hospital setting contradicts palliative goals. This study investigates patterns of end-of-life RT to inform quality improvement initiatives. METHODS: All patients who died within 6 months of starting RT at a single large academic cancer center between 2015 through 2018 were identified through our institutional databases on an Institutional Review Board-approved protocol. Clinical factors including age, treatment service, number of fractions, diagnosis, treatment site, and treatment date were evaluated for associations with endpoints, 30-day mortality and on-treatment mortality (mid-course), via logistic regression analysis. RESULTS: 1,855 patients died within 6 months of initiating RT at our center. Of these, 619 patients (33%) died within 30 days of starting RT, and were most commonly treated by thoracic (26%), CNS (21%), and hematologic (13%) services. Commonly treated sites included brain/spine (27%), bone (26%), and mediastinum/thorax (10%). On logistic regression, both extended radiotherapy prescription fractionation (>10 fractions/course) [OR 0.50, p<0.001] and advanced stereotactic treatment technique (OR 0.61, p=0.002) were associated with decreased likelihood of 30-day mortality, reflecting appropriate clinical rationale of treating providers. Neither age (≥70 vs. <70 years) [OR 0.93, p=0.538] nor treatment year (2017-2018 vs. 2015-2016) [OR 0.97, p=0.744] were associated with 30-day mortality. Of the 619 patients, 142 (23%) died midway before completion of RT course. Patients treated for emergent palliative mediastinal/thoracic indications (OR 11.4, p<0.001) were more likely to die midway through RT than those treated for bone metastases. Notably, 2 out of every 3 patients treated for emergent palliative mediastinal/thoracic indications (e.g. airway obstruction, hemoptysis) died ontreatment, comprising 27% of all on-treatment deaths (p<0.001). CONCLUSION: Palliative RT remains an important therapeutic tool at the end-oflife. However, careful consideration of RT for emergent mediastinal/thoracic indications should be used, given the high potential for on-treatment mortality. Taken together, these data may help inform physician decision-making and facilitate treatment consistent with palliative goals at the end-of-life.