Miracle-dz/UniFAR-FTUs huggingface dataset:
Asynchronous Transfer Mode Networks: Performance Issues, Second Edition

From the Publisher: This updated version of the best-selling first edition is a one-source reference to ATM networks. Written by one of the engineers developing IBM's ATM architecture, it provides a comprehensive review of current and emerging ATM standards, including P-NNI. Unlike traditional standards documents, this book is easy to follow and serves as a readily accessible reference for system designers, researchers, marketing staff, and graduate students of high-speed networking. Features 200 equations and 119 figures.
The metaphoric representation of time: a cognitive linguistic perspective

It has long been observed that speakers systematically employ language from concrete and perceptually rich domains to talk about abstract concepts. One of the paradigm examples of this is the way in which the abstract domain TIME is metaphorically conceptualised in terms of the concrete domain SPACE in a wide range of languages throughout the world. In English, there are various types of spatial metaphors for time, including ‘deictic’ metaphors, which situate events in relation to the ego, ‘sequential’ metaphors, which position events in relation to one another, as part of a sequence and ‘extrinsic’ metaphors, which fix events in relation to the forward-moving flow of time. Of these, particular attention has been paid to two deictic space-time metaphors: the Moving Ego metaphor, which conceptualises the self as moving towards events in time, e.g. We’re approaching Christmas and the Moving Time metaphor, which conceptualises events in time moving relative to the self, e.g. Christmas is approaching. In addition to linguistic evidence, a body of research has provided evidence for the psychological reality of these two metaphors, demonstrating that thinking about spatial motion under various circumstances can prime different construals of time. While research investigating abstract thinking about time has been primarily focused on examining the effects of spatial priming on temporal reasoning, recent research has extended beyond this, providing preliminary evidence that personality differences, emotional experiences and the valence of an event (positive or negative) may also influence people’s perspectives on the movement of events in time. By building upon and extending these findings, the overall aim of this thesis is to shed light on the mechanisms at work during the interpretation of language in context, providing a more fully explanatory framework for the metaphoric representation of time. To do this, a series of studies were conducted to examine further the range of factors that may influence how people reason about events in time, focusing specifically on previously unexplored personality differences, lifestyle differences and behavioural differences (Studies 1 to 8). Next, the focus of the investigation turned to the interpretation and usage of metaphorical expressions about time in prescribed contexts (Studies 9 to 14). The findings of these studies are reported and discussed in terms of the theoretical, methodological and practical issues they raise for the language sciences.
Investing in Successful Summer Programs: A Review of Evidence Under the Every Student Succeeds Act

Program providers and funders who decide how best to invest limited resources to meet goals for children and youth in the summer are increasingly encouraged by policymakers to base their decisions on research evidence. This report, which provides a systematic review of the evidence supporting summer programs and descriptions of evidence-based programs, is intended to provide guidance regarding the effectiveness of summer interventions.
Modeling an Alternate Operational Ground Source Heat Pump for Combined Space Heating and Domestic Hot Water Power Sizing

This study developed an alternate operational control system for ground source heat pumps (GSHP), which was applied to determine combined space heating and domestic hot water (DHW) power equations at design temperature. A domestic GSHP with an alternate control system was implemented in a whole building simulation model following the heat deficiency for space heating based on degree minute counting. A simulated GSHP system with 200 L storage tank resulted in 13%–26% power reduction compared to the calculation of the same system with existing European standards, which required separate space heating and DHW power calculation. The periodic operation utilized the thermal mass of the building with the same effect in the case of light and heavy-weight building because of the very short cycle of 30 min. Room temperatures dropped during the DHW heating cycle but kept within comfort range. The developed equations predict the total power as a function of occupancy, peak and average DHW consumption with variations of 0%–2.2% compared to the simulated results. DHW heating added the total power in modern low energy buildings by 21%–41% and 13%–26% at design temperatures of −15 °C and −26 °C, respectively. Internal heat gains reduced the power so that the reduction effect compensated the effect of DHW heating in the case of a house occupied by three people. The equations could be used for power sizing of any heat pump types, which has alternate operation principle and hydronic heating system.
Adrenergic to mesenchymal fate switching of neuroblastoma occurs spontaneously in vivo resulting in differential tumorigenic potential

Neuroblastoma is a pediatric tumor that originates from cells of the adrenergic lineage. Here we investigated the balance between differentiation and dedifferentiation in relation to tumor-engraftment potential in preclinical mouse models. We analyzed intratumoral heterogeneity through comparison of marker expression of normal adrenergic development versus tumor marker expression, which showed the presence of sympathoadrenal as well as mesenchymal subtypes of neuroblastomas cells. Subsequently, we evaluated long-term outgrowth capacity of these two (FACS-sorted) cell populations, which showed that adrenergic cells have a stronger long-term clonogenic potential. Engraftment of these sorted populations into mice revealed the occurrence of heterogeneous populations. Modelling of the interconversion rate indicated that cell fate transitions from the adrenergic to mesenchymal state were obtained gradually and stochastically as the tumors grew in mice. We found that adrenergic cells have an increased tumorigenic potential in mice without signs of beneﬁcial cross talk between the two lineage populations. These ﬁndings indicate that neuroblastoma contains two rivalling differentiation states that exhibit differences in long term clonal/tumorigenic potential. We expect these states to be relevant for therapy resistance as a result of intratumoral heterogeneity
Leveraging Technology for Talent Management: Foresight for Organizational Performance

This study aims to understand the use of technology for talent management and its impact on organizational performance. This study reviewed the extant literature and conducted semi-structured interviews of 125 HR managers in multinational companies in India to understand the impact of technology in talent management for organizational performance. The research utilized the grounded theory approach to conduct the interviews and the analysis of the data was done with NVivo 8.0 software. It was found that organizational performance can be achieved by using technology for talent management. It highlights the role of talent metrics and analytics and HR business partnerships in organizational performance. This study proposes a theoretical model for the usage of talent management technology towards organizational performance using the grounded theory perspective. This study provides key insights for the HR managers, talent management technology marketers and developers.
The effect of thermal processing on the reduction of deoxynivalenol and zearalenone cereal content

Fusarium mycotoxins deoxynivalenol (DON) and zearalenone (ZEN) often contaminate cereals and cereal by-products. Certain thermal processing methods used in the food industry show promising results in terms of reduction of cereal contamination with mycotoxins. In order to establish the degree of DON and ZEN reduction in naturally contaminated cereals (maize, wheat and oat), this study investigated the effects of cooking, roasting and extrusion cooking, performed at different temperatures (100 – 220 °C) and for a different length of time (10 – 30 min) on these mycotoxins concentrations. Before and after the treatment, cereal samples were analysed for DON and ZEN concentrations using enzyme-linked immunosorbent assay (ELISA). In comparison to cooking, which achieved only a negligible mean mycotoxin reduction (of up to 8% for DON and 11% for ZEN), roasting and extrusion cooking resulted in a significantly more pronounced mycotoxin reduction (of up to 40% for DON & 46% for ZEN and of up to 75% for DON & 80% for ZEN, respectively) (p < 0.05). The results show similar effects of thermal processing on all of the studied cereals (p > 0.05), suggesting that extrusion cooking can be considered as an effective thermal method capable of reducing mycotoxin content in cereals.
The NKCC1 antagonist bumetanide mitigates interneuronopathy associated with ethanol exposure in utero

Prenatal exposure to ethanol induces aberrant tangential migration of corticopetal GABAergic interneurons, and long-term alterations in the form and function of the prefrontal cortex. We have hypothesized that interneuronopathy contributes significantly to the pathoetiology of fetal alcohol spectrum disorders (FASD). Activity-dependent tangential migration of GABAergic cortical neurons is driven by depolarizing responses to ambient GABA present in the cortical enclave. We found that ethanol exposure potentiates the depolarizing action of GABA in GABAergic cortical interneurons of the embryonic mouse brain. Pharmacological antagonism of the cotransporter NKCC1 mitigated ethanol-induced potentiation of GABA depolarization and prevented aberrant patterns of tangential migration induced by ethanol in vitro. In a model of FASD, maternal bumetanide treatment prevented interneuronopathy in the prefrontal cortex of ethanol exposed offspring, including deficits in behavioral flexibility. These findings position interneuronopathy as a mechanism of FASD symptomatology, and posit NKCC1 as a pharmacological target for the management of FASD.
GABAergic cell loss in mice lacking autism-associated gene Sema6A

Background During brain development, a multitude of neuronal networks form as neurons find their correct position within the brain and send out axons to synapse onto specific targets. Altered neuronal connectivity within these complex networks has been reported in Autism Spectrum Disorder (ASD), leading to alterations in brain function and multisensory integration. Semaphorins (also referred to as Semas), a large protein family of about 30 members, have been shown to play an important role in neuronal circuit formation and have been implicated in the etiology of ASD. The purpose of the current study is to investigate how Sema6A mutation affects neuronal connectivity in ASD. Since Sema6A is involved in cell migration, we hypothesized that during brain development the migration of GABAergic interneurons is affected by the loss of Sema6A gene, leading to alterations in Excitatory/Inhibitory (E/I) balance. Methods Sema6A transgenic mice were crossed with either GAD65-GFP mice or GAD67-GFP mice to allow for both a reliable and robust staining of the GABAergic interneuron population within the Sema6A mouse line. Using histological techniques we studies the expression of interneurons subtypes in the Sema6A mutant mice. Results Analysis of Sema6A mutant mice crossed with either GAD65-GFP or GAD67-GFP knock-in mice revealed a reduced number of GABAergic interneurons in the primary somatosensory cortex, hippocampus, and reticular thalamic nucleus (RTN) in adult Sema6A mutant mice. This reduction in cell number appeared to be targeted to the Parvalbumin (PV) interneuron cell population since neither the Calretinin nor the Calbindin expressing interneurons were affected by the Sema6A mutation. Limitations Although the use of animal models has been crucial for understanding the biological basis of autism, the complexity of the human brain can never truly be replicated by these models. Conclusions Taken together, these findings suggest that Sema6A gene loss affects only the fast spiking-PV population and reveal the importance of an axon guidance molecule in the formation of GABAergic neuronal networks and provide insight into the molecular pathways that may lead to altered neuronal connectivity and E/I imbalance in ASD.
Asian Zika Virus Isolate Significantly Changes the Transcriptional Profile and Alternative RNA Splicing Events in a Neuroblastoma Cell Line

Alternative splicing of pre-mRNAs expands a single genetic blueprint to encode multiple functionally diverse protein isoforms. Viruses have previously been shown to interact with, depend on, and alter host splicing machinery. The consequences however incited by viral infection on the global alternative slicing (AS) landscape are under appreciated. Here we investigated the transcriptional and alternative splicing profile of neuronal cells infected with a contemporary Puerto Rican Zika virus (ZIKVPR) isolate, the prototypical Ugandan ZIKV (ZIKVMR) isolate and dengue virus 2 (DENV2). Our analyses revealed that ZIKVPR induced significantly more differential changes in expressed genes compared to ZIKVMR or DENV2, despite all three viruses showing equivalent infectivity and viral RNA levels. Consistent with the transcriptional profile, ZIKVPR induced a higher number of alternative splicing events compared to ZIKVMR or DENV2, and gene ontology analyses highlighted alternative splicing changes in genes associated with mRNA splicing. All three viruses modulated alternative splicing with ZIKVPR having the largest impact on splicing. ZIKV alteration of the transcriptomic landscape during infection caused changes in cellular RNA homeostasis, which might dysregulate neurodevelopment and function leading to neuropathologies such as microcephaly and Guillain-Barré syndrome associated with the ZIKV infection.
Interruption of Pregnancy in Women with the Uterine Scar: Potential Risks

Summary objective: To assess the risks and identify effective and safe methods of abortion in women with uterine scar. Material: Literary sources published in the databases of Medline, PubMed, and others, of which 57 are included in this review. The main provisions: Termination of pregnancy in women with a scar on the uterus involves the use of any available method. For women with a scar on the uterus, it is necessary to prepare the cervix before a surgical abortion in all terms. Abnormal implantation of the embryo within the fibrous tissue of the scar after caesarean section can cause life-threatening bleeding of the mother during or after the termination of the pregnancy. Surgical excision of the affected area by hysteroscopic access, as well as transvaginal or transabdominal local administration of Methotrexate with or without an additional intramuscular dose of the same drug, seems to be optimal from the point of view of minimizing the frequency of complications. Conclusion: A scar on the uterus after caesarean section presents a high risk of abnormal attach-ment of the ovum and fatal bleeding during abortion. present in past medical history ): uterine scar (caesarean section or myomectomy), manual ectomy of placenta, multiple gestation, dilation and curettage, endometriosis, multiple confinement, advanced age of the mother, IVF induced pregnancy.
Experience and survival in migratory European Robins Erithacus rubecula and Song Thrushes Turdus philomelos negotiating the Baltic Sea

ABSTRACT Capsule There were survival costs for adult European Robins Erithacus rubecula grounded at coastal sites following departure, but not for young Robins or Song Thrushes Turdus philomelos. Aims To compare survival costs of crossing the Baltic Sea in autumn in adults and young of two passerines: the smaller European Robin and the slightly larger Song Thrush. Methods We calculated the mortality of experienced adults and those embarking on their first migration, modelling survival in a capture-mark-recapture framework using ringing records from three bird observatories on the periphery of the Baltic Sea. We tested the subsequent age- and species-dependent 12-month interval survival of autumn migrants caught before, during and after the barrier. Results Survival did not differ in relation to the capture site, however, results revealed species-specific post-capture survival. Adult European Robins encountering an ecological barrier on autumn migration had lower survival probability than that of immature birds, and less than a third of adults at following intervals. Yet, in Song Thrushes, adult survival estimates were similar over all time intervals, and estimates for both age classes were comparable to those derived from breeding sites. Conclusion Experienced individuals of the smaller species are likely to become grounded at the periphery of the ecological barrier as a result of physiologically limiting conditions. Species- and age-dependent survival also highlights potential inherent biases of sampling birds at coastal bird observatories.
Brown Rice Versus White Rice: Nutritional Quality, Potential Health Benefits, Development of Food Products, and Preservation Technologies.

Obesity and chronic diet-related diseases such as type 2 diabetes, hypertension, cardiovascular disease, cancers, and celiac are increasing worldwide. The increasing prevalence of these diseases has led nutritionists and food scientists to pay more attention to the relationship between diet and different disease risks. Among different foods, rice has received increasing attention because it is a major component of billions of peoples' diets throughout the world. Rice is commonly consumed after polishing or whitening and the polished grain is known a high glycemic food because of its high starch content. In addition, the removal of the outer bran layer during rice milling results in a loss of nutrients, dietary fiber, and bioactive components. Therefore, many studies were performed to investigate the potential health benefits for the consumption of whole brown rice (BR) grain in comparison to the milled or white rice (WR). The objective of this work was to review the recent advances in research performed for purposes of evaluation of nutritional value and potential health benefits of the whole BR grain. Studies carried out for purposes of developing BR-based food products are reviewed. BR safety and preservation treatments are also explored. In addition, economic and environmental benefits for the consumption of whole BR instead of the polished or WR are presented. Furthermore, challenges facing the commercialization of BR and future perspectives to promote its utilization as food are discussed.
Yield Performance and Nutrient Uptake of Red Rice Variety (MRM 16) at Different NPK Fertilizer Rates

Global demand for high-quality rice and healthy food has increased, especially to the affluent and health-conscious consumers. Red rice has been consumed because of its health benefits. Red rice has met the concepts of productivity and quality that emerged to supply the demands for products that improve the eating pattern of its consuming population. Red rice is based on food industries especially for nutrition-based food products and baby food products. For the case on Malaysia, limited domestic supplies of red rice have led to full dependency on imported red rice supplies in the country. Recent statistics showed that the Sarawak state can be one of the potential areas for the development of red rice production due to its vast land resources; proper guidelines which suit the agroecosystem in Sarawak for cultivation of red rice are essential. As for rice production in general, proper application of fertilizers enhances the yield and to a certain extent sustains soil productivity. Considering the needs to establish a proper fertilizing program especially for red rice production in Sarawak, a preliminary study was conducted to evaluate the yield and yield components of red rice variety (MRM 16) with three levels of NPK fertilizers (Treatment 1, control; Treatment 2, 60 : 35 : 40; Treatment 3, 120 : 70 : 80; and Treatment 4, 180 : 105 : 120 (proportions of N, P2O5, and K2O·ha−1, respectively)). The experiment was conducted in the pot trial during main season 2016 (December 2016–April 2017). The yield parameters including rice yield, panicle no./m2, 1000-grain weight, spikelet number per panicle, and percentage of filled spikelets were collected. The results showed that yield was not significantly affected by the increment of the NPK fertilizer added at a rate of more than 60 kg/ha N, 35 kg/ha P, and 40 kg/ha K (T2). From the study, it was observed that the yield and yield components of red rice variety (MRM 16) were best in T2 (60 kg/ha N, 35 kg/ha P, and 40 kg/ha K).
Spino-pelvic radiological parameters in patients presenting with low back pain in a tertiary care centre in India

Objectives: Low back pain is one of the most common and disabling morbidities in the world and its relationship with spino-pelvic parameters is not yet fully understood in the Indian population. Our objective was to study the spino-pelvic parameters in patients who presented to the OPD with low back ache (LBA). Materials and Methods: Cross-sectional study conducted at SGITO, Bangalore between March-August 2018. 90 patients with LBA were asked to take standing lateral radiographs showing the pelvis with both hips and lumbar spine. The lumbar lordosis (LL), pelvic incidence (PI), pelvic tilt (PT), and sacral slope (SS) were calculated; and statistical analysis was done. Results: The mean age of patients was 46 years. The average duration of LBA was 14.5 months. The average PI, SS, PT, and LL among the patients was found to be 52.53 (+/-10.85), 35.08 (+/-9.17), 17.56 (+/-7.72), and 49 (+/-3) respectively. PI had statistically significant association with PT and SS but not with LL among both men and women in all age groups. Mean PI and PT was found to be higher in women (53.82+/11.85) (18.35 +/8.45) and in above 50 years age group (54.58 +/-11.41). Similarly, the mean PT was higher in among women (18.35 +/8.45) and in the above 50 years age group (18.93 +/8.02). The duration of lower back pain was found to be positively associated with PI, SS, PT, and LL but didn’t reach statistical significance. Conclusion: Spino-pelvic alignment is maintained in patients with low back pain and differences in sagittal alignment in patients with low back ache are minor and clinically, multiple factors contribute to LBA. However, further studies need to be conducted to corroborate these findings in the Indian population which may help in early detection and management of patients prone to develop lumbar disc degeneration and low back ache.
Research and Statistics on Libraries and Librarianship in 2006

Each year I identify a few research areas that were unusual or prominent. This year I am drawing on longitudinal research of libraries (somewhat more traditional) and some new research employing quantitative and observational methods. The following article highlights library statistics for the year, including the latest ALA Association of School Librarians (AASL) study, School Libraries Count! , and two issues briefs from the Public Library Funding and Technology Access Study. The research topic is Web 2.0 and social networking research, and four research projects focused in these areas published in 2009 are noted.