Miracle-dz/UniFAR-FTUs huggingface dataset:
Hyponatremia With Intravenous Sulfamethoxazole/Trimethoprim in Children

Background: Intravenous (IV) sulfamethoxazole/trimethoprim (SMX/TMP) has been associated with hyponatremia in adults. Objective: The primary objective was to identify the number of patients with a serum sodium <135 mEq/L. Secondary objectives between the hyponatremic versus nonhyponatremic groups included demographic comparisons, median serum sodium concentrations, SMX/TMP cumulative dose, number of diuretics, and other medications causing hyponatremia. Methods: This was a retrospective study of children <18 years receiving IV SMP/TMX. Comparisons were conducted via Mann-Whitney-Wilcoxon and Mantel-Haenszel χ2 tests with an a priori P value <0.05. Results: Sixty-one patients received 66 total courses; 20 courses (30.3%) were associated with hyponatremia with a decrease in the median nadir serum sodium concentration of 133 and 138 mEq/L in the hyponatremic and nonhyponatremic groups, respectively (P<0.001). The median age (interquartile range) was lower in the hyponatremic versus nonhyponatremic group, but this was not statistically significant: 0.6 (0.1-5.5) versus 3.9 (0.3-11.0) years; P=0.077. There was no significant difference in the median cumulative dose (mg/kg) between groups; P=0.104. In addition, there was a significant difference in the number of children in the hyponatremic versus nonhyponatremic groups receiving diuretics (16 [80.0%] vs 23 [50.0%], P=0.023) and other medications that cause hyponatremia (7 [35.0%] vs 5 [10.9%], P=0.034), respectively. Furosemide was noted to be the medication most associated with hyponatremia. Conclusion and Relevance: Approximately one-third administered IV SMX/TMP developed hyponatremia. Concomitant furosemide administration was one of the most common risk factors. Clinicians should be aware of this potential adverse event when initiating IV SMX/TMP in children.
Developing quality fidelity and engagement measures for complex health interventions

Objectives To understand whether interventions are effective, we need to know whether the interventions are delivered as planned (with fidelity) and engaged with. To measure fidelity and engagement effectively, high‐quality measures are needed. We outline a five‐step method which can be used to develop quality measures of fidelity and engagement for complex health interventions. We provide examples from a fidelity study conducted within an evaluation of an intervention aimed to increase independence in dementia. Methods We propose five steps that can be systematically used to develop fidelity checklists for researchers, providers, and participants to measure fidelity and engagement. These steps include the following: (1) reviewing previous measures, (2) analysing intervention components and developing a framework outlining the content of the intervention, (3) developing fidelity checklists and coding guidelines, (4) obtaining feedback about the content and wording of checklists and guidelines, and (5) piloting and refining checklists and coding guidelines to assess and improve reliability. Results Three fidelity checklists that can be used reliably were developed to measure fidelity of and engagement with, the Promoting Independence in Dementia (PRIDE) intervention. As these measures were designed to be used by researchers, providers, and participants, we developed two versions of the checklists: one for participants and one for researchers and providers. Conclusions The five steps that we propose can be used to develop psychometrically robust and implementable measures of fidelity and engagement for complex health interventions that can be used by different target audiences. By considering quality when developing measures, we can be more confident in the interpretation of intervention outcomes drawn from fidelity and engagement studies. Statement of contribution What is already known on the subject? Fidelity and engagement can be measured using a range of methods, such as observation and self‐report. Studies seldom report psychometric and implementation qualities of fidelity measures. What does this study add? A method for developing fidelity and engagement measures for complex health interventions. Guidance on how to consider quality when developing fidelity and engagement measures.
Coupled Cation-Anion Dynamics Enhances Cation Mobility in Room Temperature Superionic Solid-State Electrolytes.

Single-ion conducting solid electrolytes are gaining tremendous attention as essential materials for solid-state batteries, but a comprehensive understanding of the factors that dictate high ion mobility remains elusive. Here, for the first time, we use a combination of the Maximum Entropy Method analysis of room-temperature neutron powder diffraction data, ab initio molecular dynamics and joint-time correlation analysis to demonstrate that the dynamic response of the anion framework plays a significant role in the new class of fast ion conductors, Na11Sn2PnX12 (Pn = P, Sb; X = S, Se). Facile [PX4]3- anion rotation exists in superionic Na11Sn2PS12 and Na11Sn2PSe12, but greatly hindered [SbS4]3- rotational dynamics are observed in their less conductive analogue, Na11Sn2SbS12. Along with introducing dynamic frustration in the energy landscape, the fluctuation caused by [PX4]3- anion rotation is firmly proved to couple to, and facilitate long range cation mobility, by transiently widening the bottlenecks for Na+-ion diffusion. The combined analysis described here resolves the role of the long debated paddle-wheel mechanism, and is the first direct evidence that anion rotation significantly enhances cation migration in rotor phases. The joint time correlation analysis developed in our work can be broadly applied to analyze coupled cation-anion interplay where traditional transition state theory does not apply. These findings deliver important insights into the fundamentals of ion transport in solid electrolytes. Invoking anion rotational dynamics provides a vital strategy to enhance cation conductivity and serves as an additional and universal design principle for fast ion conductors.
Indomethacin enhances anti-tumor efficacy of a MUC1 peptide vaccine against breast cancer in MUC1 transgenic mice

In recent years, vaccines against tumor antigens have shown potential for combating invasive cancers, including primary tumors and metastatic lesions. This is particularly pertinent for breast cancer, which is the second-leading cause of cancer-related death in women. MUC1 is a glycoprotein that is normally expressed on glandular epithelium, but is overexpressed and under-glycosylated in most human cancers, including the majority of breast cancers. This under-glycosylation exposes the MUC1 protein core on the tumor-associated form of the protein. We have previously shown that a vaccine consisting of MUC1 core peptides stimulates a tumor-specific immune response. However, this immune response is dampened by the immunosuppressive microenvironment within breast tumors. Thus, in the present study, we investigated the effectiveness of MUC1 vaccination in combination with four different drugs that inhibit different components of the COX pathway: indomethacin (COX-1 and COX-2 inhibitor), celecoxib (COX-2 inhibitor), 1-methyl tryptophan (indoleamine 2,3 dioxygenase inhibitor), and AH6809 (prostaglandin E2 receptor antagonist). These treatment regimens were explored for the treatment of orthotopic MUC1-expressing breast tumors in mice transgenic for human MUC1. We found that the combination of vaccine and indomethacin resulted in a significant reduction in tumor burden. Indomethacin did not increase tumor-specific immune responses over vaccine alone, but rather appeared to reduce the proliferation and increase apoptosis of tumor cells, thus rendering them susceptible to immune cell killing.
Associations between 100% Orange Juice Consumption and Dietary, Lifestyle and Anthropometric Characteristics in a Cross-Sectional Study of U.S. Children and Adolescents

Concerns about orange juice’s sugar content have spurred discussions regarding its potential contributions to childhood obesity. The objective of this study was to evaluate the association between 100% orange juice (OJ) consumption and dietary, lifestyle and anthropometric characteristics in children and adolescents. Baseline anthropometric, dietary and lifestyle data from the Growing Up Today Study I (GUTS I) and GUTS II were collected via self-reported questionnaires from 26,554 participants. The mean values of these variables were then computed for children grouped by categories of OJ consumption, and linear trend testing was used to determine whether OJ consumption was linearly related to these variables. Multivariate adjustment modeling was used to calculate odds ratios of being obese or overweight/obese by OJ consumption. Among both boys and girls, OJ intake was positively associated with height, height-for-age z-score (HAZ), intakes of total energy, total energy excluding OJ, fruits and non-starchy vegetables and physical activity. BMI, BMI z-score and BMI-for-age percentile did not differ by OJ consumption. After adjustment for cohort, age, race, total energy intake without OJ, physical activity and screen time, prevalence of overweight/obesity significantly decreased by OJ intake in boys compared to non-consumers (odds ratio (OR) and 95% confidence interval (CI)): 1.17 (1.02, 1.33) for 1–3 glasses per month, 1.11 (0.98, 1.26) for 1–6 glasses per week, 1.00 (0.85, 1.18) for 1 glass per day, 0.91 (0.73, 1.13) for ≥1 glass per day, p-trend = 0.0403). Prevalence of obesity similarly decreased by OJ intake in boys. Prevalence of overweight/obesity and obesity did not significantly differ by OJ intake in girls. The results indicate that children consuming more OJ tended to practice healthier dietary and lifestyle habits without increased prevalence or odds of obesity or overweight.
EVALUATION OF QUALITY OF LIFE IN PATIENTS WITH CORONARY ARTERY BYPASS SURGERY USING CONTROLLED CLINICAL TRIAL

Quality of life has emerged as an important concept and outcome in health and health care. This study was performed to evaluate the ability of the health education program to improve quality of life of patients with coronary artery bypass graft surgery (CABG). In pre operation period, 70 patients were randomized in two groups, experimental and control group (35 patients in each). The demographic information, SF-36 and Nottingham Health Profile questionnaire were administered before surgery to all patients. Patients in the experimental group received the educational intervention according to Micos education planning model. These patients were followed up to 1-month. At result, SF-36, Nottingham Health Profile questionnaires were administered 1-month after education by patients again. Significant improvements in quality of life between two groups, as measured by the Nottingham Health Profile, were seen in energy (P < 0.001), pain (P < 0.006), emotional reaction (P < 0.00001), sleep (P < 0.01), physical mobility (P < 0.00001) and total average quality of life (P < 0.00001). Significant improvements in quality of life between two groups, as measured by the SF-36, were seen in physical function (P < 0.00001), role limitations resulting from emotional status (P < 0.007), role limitations resulting from physical status (P < 0.05), mental health (P < 0.03), vitality (P < 0.02) and total average quality of life (P < 0.02). The findings demonstrate that health education result is improved quality of life for patients with CABG. © 2007 Tehran University of Medical Sciences. All rights reserved. Acta Medica Iranica, 45(1): 69-75; 2007
Seismic location and tracking of snow avalanches and slush flows on Mt. Fuji, Japan

Abstract. Avalanches are often released at the dormant stratovolcano Mt. Fuji, which is the highest mountain of Japan (3776 m a.s.l.). These avalanches exhibit different flow types from dry-snow avalanches in winter to slush flows triggered by heavy rainfall in late winter to early spring. Avalanches from different flanks represent a major natural hazard as they can reach large dimensions with run-out distances up to 4 km, destroy parts of the forest, and sometimes damage infrastructure. To monitor the volcanic activity of Mt. Fuji, a permanent and dense seismic network is installed around the volcano. The small distance between the seismic sensors and the volcano flank (<10 km) allowed us to detect numerous avalanche events from the seismic recordings and locate them in time and space. We present the detailed analysis of three avalanche or slush flow periods in the winters of 2014, 2016, and 2018. The largest events (size class 4–5) are detected by the seismic network at maximum distances of about 15 km, and medium-size events (size class 3–4) within a radius of 9 km. To localize the seismic events, we used the automated approach of amplitude source location (ASL) based on the decay of the seismic amplitudes with distance from the moving flow. The recorded amplitudes at each station have to be corrected by the site amplification factors, which are estimated by the coda method using data from local earthquakes. Our results show the feasibility of tracking the flow path of avalanches and slush flows with considerable precision (on the order of magnitude of 100 m) and thus estimating information such as the approximate run-out distance and the average front speed of the flows, which are usually poorly known. To estimate the precision of the seismic tracking, we analyzed aerial photos of the release area and determined the flow path and run-out distance, estimated the release volume from the meteorological records, and conducted numerical simulations with Titan2D to reconstruct the dynamics of the flow. The precision as a function of time is deduced from the comparison with the numerical simulations, showing mean location errors ranging between 85 and 271 m. The average front speeds estimated seismically, which ranged from 27 to 51 m s−1, are consistent with the numerically predicted speeds. In addition, we deduced two scaling relationships based on seismic parameters to quantify the size of the mass flow events. Our results are indispensable for assessing avalanche risk in the Mt. Fuji region as seismic records are often the only available dataset for this natural hazard. The approach presented here could be applied in the development of an early-detection and location system for avalanches based on seismic sensors.
EFFECTS OF IRRIGATION DEFICIT AND SOWING METHODS ON GROWTH CHARACTRS AND WATER REQUIREMENTS OF SOME WHEAT CULTIVARS

In order to investigate the influence of different irrigation regimes i.e. irrigation at tillering stage (I1), at tillering and heading stage (I2) at tillering , heading and grain filling stage (I3) of the available soil moisture depletion with three methods of sowing i.e. broadcasting, drilling and beds sowing on some and characters of growth attributes, relative water content, water use efficiency and drought susceptibility index for four wheat cultivars namely; Gemmeiza-11,Misr-1, Shandaweel-1 and Sids-12. So, two field trials was carried out during 2011/12 and 2012/13 seasons, at ElGemmeiza Agric. Res. Stat. The results can be summarized as follows: Subjecting wheat plants to drought-stress resulted in a significant reduction in plant height, number of days to heading, number of days to maturity, grain filling period, flag leaf area and relative water content. Water use efficiency and total chlorophyll content tends significantly increased as irrigation regime decreased. Moreover, number of days to heading, number of days to maturity, grain filling period and flag leaf area were insignificant differed due to the tested sowing methods. However, beds sowing method was significantly differed total chlorophyll content, relative water content and water use efficiency. Gemmeiza-11 cultivar surpassed others tested cultivars with respect the abovementioned traits, except number of days to maturity since Shandaweel-1 cultivar was the earliest. Wheat plants grown under severe water deficit were more sensitive to drought. This was clear from drought sensitivity based on drought susceptibility index. Sids-12 and Misr-1 cultivars was proved to be the most drought-tolerant cultivar compared to the other tested ones.
Phonetic Normalization for Machine Translation of User Generated Content

We present an approach to correct noisy User Generated Content (UGC) in French aiming to produce a pretreatement pipeline to improve Machine Translation for this kind of non-canonical corpora. In order to do so, we have implemented a character-based neural model phonetizer to produce IPA pronunciations of words. In this way, we intend to correct grammar, vocabulary and accentuation errors often present in noisy UGC corpora. Our method leverages on the fact that some errors are due to confusion induced by words with similar pronunciation which can be corrected using a phonetic look-up table to produce normalization candidates. These potential corrections are then encoded in a lattice and ranked using a language model to output the most probable corrected phrase. Compare to using other phonetizers, our method boosts a transformer-based machine translation system on UGC.
CRYSTALLIZATION BEHAVIOUR OF THE SYSTEMS Na2O/BaO/TiO2/SiO2/B2O3/Al2O3 and Na2O/BaO/TiO2/SiO2/B2O3/Fe2O3/Al2O3

This work reports data on the synthesis of glasses in three selected compositions of each of the systems Na2O/BaO/ TiO2/SiO2/B2O3/Al2O3 and Na2O/BaO/TiO2/SiO2/B2O3/Fe2O3/Al2O3 and the preparation of glass-ceramics by applying appropriate time-temperature regimes. Crystallization of a large volume fraction of cubic BaTiO3 is observed in both systems. The phase compositions of the obtained annealed specimens are investigated by x-ray diffraction, while the microstructure of the obtained glass-ceramics is studied by optical and scanning electron microscopy. The barium titanate crystals in the samples containing iron have a size varying from ca 100 nm to some hundreds of nm. They form interconnected structures which tend to grow further for all temperature-time schedules applied. The microstructure of the annealed samples containing no iron, as proved by optical and electron scanning microscopy, is characterized by barium titanate crystals of a size of some micrometers which are uniformly dispersed in the amorphous matrix. They start to grow independently and tend to merge upon longer annealing times.
Seen the villains: Detecting Social Engineering Attacks using Case-based Reasoning and Deep Learning

Social engineering attacks are frequent, well-known and easy-to-apply attacks in the cyber domain. Historical evidence of such attacks has shown that the vast majority of malicious attempts against both physical and virtual IT systems were based or been initiated using social engineering meth-ods. By identifying the importance of tackling efficiently cybersecurity threats and using the recent developments in machine learning, case-based reasoning and cybersecurity we propose and demonstrate a two-stage approach that detects social engineering attacks and is based on natural language processing, case-based reasoning and deep learning. Our approach can be applied in offline texts or real time environments and can identify whether a human, chatbot or offline conversation is a potential social engineering attack or not. Initially, the conversation text is parsed and checked for grammatical errors using natural language processing techniques and case-based reasoning and then deep learning is used to identify and isolate possible attacks. Our proposed method is being evaluated using both real and semi-synthetic conversation points with high accuracy results. Comparison benchmarks are also presented for comparisons in both datasets.
A 2 x 2 Millimeter-Wave Microstrip Antenna Array for 5 G Applications

In this paper, microstrip antenna array is designed and simulated for 5G applications. The array was designed with the intent to cover the millimeter-wave spectrum at 27GHz frequency. The substrate used in this antenna construction is Rogers RT Duroid 6002 with a loss tangent of 0.0012 and dielectric constant 2.94. The idea behind this research is to design antenna array for 5G systems able to operate in the frequency band of 24.25 – 27.5 GHz. Initially, a conventional antenna is designed. Thereby 2X1 microstrip antenna is designed and finally, a 2X2 antenna array is designed. In each stage, the antenna parameters such as S11 parameter, gain, and VSWR are calculated. Comparisons are also drawn concerning the directivity of the three antenna configurations discussed. For the end design which involves a 2X2 microstrip antenna array, the S11 is calculated to be -31.94 dB at the frequency of 26.78 GHz. The gain achieved was 11.02 dB and the directivity is found to be 11.12 dB. All the important findings from the simulations performed are tabulated.
The Use of Penicillin for the Prevention of Pneumococcal Infection in Pediatric Patients with Sickle Cell Disease

Background: Children with sickle cell disease and asplenia are at a 30-600-fold increased risk of acquiring Streptococcus pneumoniae infection when compared to children without this disease. Prevention of such infection is vital in this population. Data sources: We searched PubMed with the key words penicillin, pediatric, pneumococcal vaccines, and sickle cell anemia and selected publications that were deemed appropriate. Results: Penicillin prophylaxis has been shown to be efficacious in children less than 5 years of age, but its therapeutic benefits in children over the age of 5 remain unknown. One Cochrane review and three randomized trials evaluated the efficacy of penicillin prophylaxis across different age groups in patients with HbSS and Sβ0Thal sickle cell disease. The rate of pneumococcal infection in the three trials combined showed a reduction (OR 0.37, 95%CI 0.16-0.86) of Streptococcus pneumoniae infection in children less than 5 years old who had received penicillin prophylaxis. The risk of such infection was lower in children over the age of 5. Long-term prophylaxis of SCD patients with penicillin poses a concern of drug-resistant strain of the S. pneumoniae and this risk continues to be a significant area of controversy. Conclusions: Infection caused by Streptococcus pneumoniae is reduced with the use of penicillin prophylaxis under the age of 5. It may be safe to discontinue prophylaxis in patients without splenectomy and history of severe pneumococcal sepsis once the patient has reached 5 years old due to unclear benefit and the potential risk of developing penicillin induced-streptococcal resistance.