Miracle-dz/UniFAR-FTUs huggingface dataset:
Tissue-engineered bone tumor as a reproducible human in vitro model for studies of anti-cancer drugs.

Studies of anticancer therapies in traditional cell culture models can demonstrate efficacy of direct-acting compounds, but lack the three-dimensional arrangement of the tumor cells and their tissue-specific microenvironments, both of which are important modulators of treatment effects in vivo. Bone cells reside in complex environments that regulate their fate and function. A bioengineered human bone-tumor model has been shown to provide a microphysiological niche for studies of cancer cell behavior. Here, we demonstrate successful transfer between two laboratories, and utility of this model in efficacy studies using well established chemotherapeutic agents. The bioengineered human bone tumor model consisted of Ewing sarcoma (RD-ES) cancer cell aggregates infused into tissue-engineered bone that was grown from human mesenchymal stem cell-derived differentiated into osteoblasts within mineralized bone scaffolds. The tumor model was maintained in culture for over 5 weeks and subjected to clinically relevant doses of linsitinib, doxorubicin, cisplatin, methotrexate, vincristine, dexamethasone, or MAP (methotrexate, doxorubicin, and cisplatin combination). Drug administration cycles were designed to mimic clinical treatment regimens. The bioengineered tumors were evaluated days to weeks after the cessation of treatment to monitor the potential for relapse, using bioengineered bone and ES cell monolayers as controls. Drug binging to the scaffolds and media proteins and gene expression were also evaluated. We show that a bioengineered human bone tumor can be used as a microphysiological model for pre-clinical studies of anticancer drugs. We found that anti-cancer efficacy was achieved at concentrations approximating the human Cmax, in contrast to traditional ES cell monolayers. Impact: These studies show that the bone tumor model can be successfully transferred between laboratories and has predictive power in preclinical studies. The effects of drugs on the bone tumors and healthy bone were studied in parallel, in support of the utility of this model for identification of new therapeutic targets.
Toxocariasis: evidencias de una enfermedad ignorada por los clínicos y los laboratorios

Toxocariasis es la infestacion helmintica en el humano por Toxocara, cuyos hospederos definitivos son el perro (Toxocara canis) y el gato domesticos (T. cati). Las hembras producen = 200 x 103 huevos/dia, expulsandolos en heces de animales infectados; su desarrollo es durante 14 a 21 dias y permanecen infectantes por anos. El ciclo de Toxocara en el humano es anormal: los huevecillos eclosionan tras la ingestion, pero las larvas no maduran, penetran la pared del intestino delgado y llegan a la circulacion portal, de alli algunas pasan a la circulacion sistemica hasta llegar a pulmones, musculos, sistema nervioso central (larva migrans visceral) y ojos (larva migrans ocular), donde se encapsulan y provocan una reaccion inflamatoria local. Larva migrans visceral semeja una alergia, acompanada de sintomas generales o especificos del organo afectado; larva migrans ocular altera la vision y hay presencia de endoftalmitis y lesiones retinianas. Existen reportes de seroprevalencia de Toxocara cercana a 60% en pacientes asmaticos; sin embargo, los clinicos que atienden a estos pacientes no consideran esta etiologia. La toxocariasis humana se diagnostica mediante deteccion de anticuerpos IgG (sensibilidad de 78% y especificidad de 92%). Las pruebas coproparasitoscopicas no son efectivas para el diagnostico, ya que el ciclo vital del gusano no presenta fase intestinal en humano.
Knowledge and Attitude on Organ Donation among Relatives of Patients on Hemodialysis in a Tertiary Care Teaching Hospital, Puducherry, South India. -

Background: Hemodialysis patients are waiting to receive the transplant kidneys. As a care giver, the relatives of patients undergoing hemodialysis should know about organ donation and transplantation. So this study will assess the existing knowledge and attitude of relatives of patients undergoing hemodialysis. Objectives: To assess the knowledge and attitude on organ donation among relatives of patients on hemodialysis Settings and design: This study was conducted among the relatives of patients undergoing hemodialysis from August to September, 2014, in one of the tertiary care teaching hospital located at Puducherry. Materials and Methods: a cross sectional study was conducted among 120 relatives of patients undergoing hemodialysis. Using a structured knowledge questionnaire and 4 point likert scale, the knowledge and attitude on organ donation were assessed respectively. Statistical analysis: Descriptive statistics and Chi-square or Fisher’s exact test were used to find out the association between the variables. Results: 86.7% of the participants had inadequate knowledge and remaining had moderately adequate knowledge and no one had adequate knowledge on organ donation. 4 (3%) had unfavorable attitude, 80 (67%) had moderately favorable attitude and 36 (30%) had favorable attitude towards organ donation. Conclusion: This study shows that the relatives of patients undergoing hemodialysis are mostly having inadequate knowledge and moderately favorable attitude towards organ donation and they need to be educated about organ donation.
Need Assessment about Managerial Education in Managers and Chief Experts of Health Vice-Chancellery of Medical Sciences Universities in Iran

Introduction: Identifying training needs and implementing appropriate courses is one of the important steps to empower managers and experts specialists. This has the most important role in improving organizational performance. In this study, considering the importance of training programs effectiveness, the training needs of managers and experts and their relation to individual and institutional factors was determined in the Health Departments of Universities of Health and Medical Sciences. Methods: This retrospective study was conducted in spring 2010. Communities of this research were the staff of Universities' Health Departments in the field of Health Deputy. They were selected from 13 universities by random systematic and stratified methods. All available directors and experts were responsibly elected and interviewed as the census. The questionnaire included individual and organizational variables and 28 management topics that confirmed validity and reliability. Results: In total 293 managers and expert specialists were studied, the average require education based on 26 (92.9 %) out of 28 subjects review, was respectively more than 3.5 (total score 5). Declaring level of training needs in a few cases had significant difference with type of universities, sex, age, work experience, educational level, MPH courses, headquarters units and the current location of the people. (P<0.05) Conclusion: According to the very high level of announced requirements, it is suggested to have short term and long term management training courses.
Nonsyndromic Hearing Loss and Deafness, DFNB1

Clinical characteristics Nonsyndromic hearing loss and deafness (DFNB1) is characterized by congenital non-progressive mild-to-profound sensorineural hearing impairment. No other associated medical findings are present. Diagnosis/testing Diagnosis of DFNB1 depends on molecular genetic testing to identify biallelic pathogenic variants in GJB2 (sequence variants as well as variants in upstream cis-regulatory elements that alter expression of the gap junction beta-2 protein [connexin 26]). Management Treatment of manifestations: Hearing aids; enrollment in appropriate educational programs; consideration of cochlear implantation for individuals with profound deafness. Surveillance: Surveillance includes annual examinations and repeat audiometry to confirm stability of hearing loss. Evaluation of relatives at risk: If both pathogenic variants have been identified in an affected family member, molecular genetic testing can be used to clarify the genetic status of an at-risk relative in childhood so that appropriate early support and management can be provided. Genetic counseling DFNB1 is inherited in an autosomal recessive manner. In each pregnancy, the parents of a proband have a 25% chance of having a deaf child, a 50% chance of having a hearing child who is a carrier, and a 25% chance of having a hearing child who is not a carrier. When the GJB2 pathogenic variants causing DFNB1 are detected in an affected family member, carrier testing for at-risk relatives, prenatal testing for pregnancies at increased risk, and preimplantation genetic testing are possible.
Woody Species Richness and Diversity Following Successional Stages at Jello-Muktar Dry Afromontane Forest, South-eastern Ethiopia

The study was carried out at 8055’N-9005’N latitude and 40050’E-40051’E longitude, at Jello-Muktar dry Afromontane forest South eastern Ethiopia to analyze changes in species composition, diversity and species richness under three successional stages. Three sites were selected each with 10 sample plots from each succssional stage. The average distance between the plots was 200 m and the radius was 30m. In each plot, identification, counting and measurement of diameter at breast height (DBH) of all trees and shrubs (DBH≥10cm) was conducted. Comparison of richness (S) between sites and successional stages was analyzed by Chao2 estimator and Rarefaction was performed to compare species richness among sites and successional stages, for unequal number of individuals in sites. The Shannon-Wiener (H’) and the Pielou indices (E) were used to assess the species diversity and evenness indices. A total of 114 species corresponding to 76 tree and 38 shrub species were recorded in the three successional stages. The MS forest was found to have the highest species richness followed by IS and ES successional stages. Analysis of Chao 2 estimator revealed that an average of 89.6% of the total species expected had been found for each successional stage. The MS sites were also found to have the highest mean H’ and H’E indices. The Overall mean measure of evenness was about 0.86 which indicates that the relative homogeneity of the species in the samples was 86% of the maximum possible even population. Different conservation priorities should be implemented to maintain plant species at different successional stages.
THE EFFECT OF BOARD DIVERSITY ON THE EXTENT OF INTELLECTUAL CAPITAL DISCLOSURE (EMPIRICAL STUDY IN INDONESIAN STOCKS EXCHANGE)

Board structure as one of corporate governance mechanism has two primary roles, which are service or advisory role and control role. One of the main issues associated with board structure and board role is board diversity. Board diversity is divided into demographic diversity and cognitive diversity. This research examined the effect of board diversity on the disclosure of intellectual capital. Samples in this research were financial companies listed on the Indonesia Stock Exchange during the period 2004-2009. The sample obtained by purposive sampling, and 33 companies fit with the sample criteria. The hypothesis tested by using multiple regression analysis. The result of hypothesis testing shows that gender diversity and diversity of nationality influence the intellectual capital disclosure. The result also shows that variation of formal education background (education diversity) and proportion of outside director (board‟s independence) has no effect on intellectual capital disclosure. Firm size as a control variable is also has positive effect on intellectual capital disclosure.
The Biological Benefits of Blackmulberry ( Morus nigra ) Intake on Diabetic and non Diabetic Subjects

The intake of fresh blackmulberry on some blood categories and blood pressure in diabetic and non-diabetic subjects was studied. From Public Hospital District in Cairo, 12 Type II Diabetes Mellitus (DM) and 26 non-diabetic subjects (29-74 yrs) both sexes were choosing on purpose. Eating 100 g fresh black mulberry were given daily to each subject for one month. Blood pressure was measured then fasting blood samples were taken twice before and after the month of fruit intake (pre & post) for analysis. Personal data, dietary habits, body weight (WT) and height (HT) were recorded. Nutrients or hormone supplements were not permitted. Nutritive values of the fruits were assessed using Food Composition Tables and compared with Recommended Dietary Allowances (RDA) and Dietary References Intake (DRI). T-test and percent alteration were done for differences between the two groups and (pre & post). Some risky factors were found in the lifestyle of the two groups which lead them in poor nutritional status. Results obtained showed that blackmulberry has the highest minerals and energy compared with all fresh fruits and other berry types. One hundred grams of this fruit provides with 18.6% of RDA, DRI for iron, 22.22% of Vitamin C for adolescence, 13% of Zn for children (1-10) yrs. Blood glucose, total cholesterol, creatinine, uric acid and blood pressure were reduced significantly while hemoglobin was increased significantly by daily eating of this fruit. Significant differences were found between DM and non-DM groups as well as pre & post. Therefore, blackmulberry has a therapeutic and improvement effects in DM & non-DM subjects. It could be considered as supplement food for anemic, diabetic, hypertensive and other nutrition risk groups. Besides, it is the cheapest and available nutritious spring fruit in Egypt which need more attention for its cultivation, marketing, storage and industry.
On τ-tilting finite simply connected algebras

We show that τ -tilting ﬁnite simply connected algebras are representation-ﬁnite. Then, some related algebras are considered, including iterated tilted algebras, tubular algebras and so on. We also prove that the τ -tilting ﬁniteness of non-sincere algebras can be reduced to that of sincere algebras. This motivates us to give a complete list of τ -tilting ﬁnite sincere simply connected algebras.
Efficacy of Vitamin K 2 for Glucocorticoid-induced Osteoporosis in Patients with Systemic Autoimmune Diseases

Objective Vitamin K2 (menatetrenone) is an effective treatment for patients with postmenopausal osteoporosis. We herein performed a subanalysis of patients with systemic autoimmune diseases undergoing glucocorticoid therapy in our previous prospective study. Methods Sixty patients were categorized into a group with vitamin K2 treatment (n=20, Group A) and a group without vitamin K2 treatment (n=40, Group B). All patients were treated with bisphosphonates. Results Serum levels of osteocalcin and undercarboxylated osteocalcin decreased significantly after the start of glucocorticoid therapy in both groups, while the serum osteocalcin level was significantly higher in Group A than Group B during the third (p=0.0250) and fourth weeks (p=0.0155). The serum level of the N-terminal peptide of type I procollagen, a bone formation marker, decreased during glucocorticoid therapy, but was significantly higher in Group A than Group B during the fourth week (p=0.0400). The bone mineral density and fracture rate showed no significant differences between the two groups. Conclusion Although vitamin K2 improves bone turnover markers in patients with osteoporosis on glucocorticoid therapy, it has no significant effect on the bone mineral density and fracture rate after 1.5 years of
Product Market Competition and the Pro tability Premium November 2018

This paper studies the impact of product market competition on the positive relation between pro tability and average stock returns. I nd that pro tability positively predicts returns, only among rms in competitive industries. A long-short portfolio sorted on pro tability earns an average monthly return of 1.1% in competitive industries, and only 0.14% in concentrated industries. This di erent performance is largely driven by rm's di erent exposures to investment-speci c technology (IST) shocks. I develop a production-based asset pricing model with imperfect competition and growth opportunities. I show that monopolies have less incentive to invest when facing IST shocks. Thus market power lets the rms better hedge IST shocks, lowering their risk exposures than rms in competitive industries. Empirical tests on investment responses con rm the model's predictions.
Can Firms Be Both Broad and Deep? Exploring Interdependencies Between Horizontal and Vertical Firm Scope

Firms can be horizontally diversified, with considerable breadth, or vertically integrated, with great depth. This study explores how breadth and depth affect each other as influenced by capability requirements and coordination demands. Using construction industry data, we assess the interdependence between contractors’ portfolios of building types (horizontal scope) and the extent of integration of the activities needed to complete each project (vertical scope). We find that vertical and horizontal scope have a negative interdependency only when contractors face managerial constraints due to coordination challenges. Further, we show that this effect can be mitigated through organizational structures that centralize key functions. Our findings highlight the importance of coordination in the theory of the firm, as we link firm boundaries to managerial coordination and internal organization.
EFFECTS OF A HIGH-PROBABILIT Y INSTRUCTIONAL SEQUENCE ON GENER ALIZED FOOD CONSUMPTION EFECTO DE UNA SECUENCIA INSTRUCCIONAL DE ALTA

The purpose of the current study was to examine the effects of delivering a high-probability instructional sequence on generalized consumption of nonpreferred foods with similar properties to treatment foods. The participant was a 5-year-old, typically-developing child with a history of food selectivity. The participant was asked to complete each step of an instructional sequence in which the final step was consumption of a nonpreferred food. Praise was delivered after compliance to complete each step and a preferred food was delivered after compliance with the Varsovia Hernández Eslava, Centro de Estudios e Investigaciones en Conocimiento y Aprendizaje Humano (CEICAH), Universidad Veracruzana, Jonathan K. Fernand, Aurora University. The first author was supported by grant #264560 from CONACYT. Correspondence concerning this study should be addressed to Varsovia Hernández, Centro de Estudios e Investigaciones en Conocimiento y Aprendizaje Humano, Av. Orizaba No. 203, Fraccionamiento Veracruz Xalapa, Veracruz. México, C. P. 91120. varsovia.eslava@gmail.com Revista Mexicana de Análisis de la Conducta • Mexican Journal of Behavior Analysis 2018 | Núm. 2 • diciembre | No. 2 • December | Vol. 44, 97 115 http://dx.doi. org/10.5514/rmac.v44. i2.68546 final step. The high-probability instructional sequence was effective in increasing consumption of nonpreferred foods and generalization was observed to nontarget foods with similar properties. The importance of tailoring procedures to treat food selectivity displayed by typically developing children is discussed.
A Multi-Level Evaluation of the Relationship Between Leadership Program Satisfaction, Opinion Leadership, and Intent to Participate in an Alumni Program

A census of 23 adult leadership development programs including 2,200 individuals from 262 classes investigated the influence of the group level (class) elements on individual intentions to participate in alumni programming. Individual and group level effects were evaluated, specifically, level of individual and group satisfaction as well as level of individual and group opinion leadership. The results indicate there are group level differences in intentions to participate, albeit small. Additionally, group level satisfaction was a significant positive predictor of intention. Individual satisfaction was found to have a significant positive effect; however, opinion leadership was found to have a significant negative effect on intentions to participate. Finally, group satisfaction was the only significant predictor found when analyzing both individual and group level variables simultaneously.
P 4 . 33 CONTRAIL COVER AND RADIATIVE PROPERTIES FROM HIGH-RESOLUTION SATELLITE DATA

Increasing jet air traffic and the coincident rise in jet engine efficiency have resulted in the apparent increase in cirrus cloudiness through the formation of persistent contrails. Minnis et al. (2000) found that cirrus cloud amounts have increased over most air traffic regions with the strongest trends over the USA where cirrus coverage rose by an average of 0.027 between 1971 and 1996. In order to evaluate the potential impact of these contrails on climate, it is necessary to determine the coverage and the radiative properties of contrails. This paper presents recent results from a continuing study of contrails using satellite data to determine contrail coverage and optical properties. Results are presented for selected areas of the USA during 1998 and 2001.
EFFECTS OF FRAUD MANAGEMENT STRATEGIES ON THE PERFORMANCE OF SELECTED MICRO-FINANCE INSTITUTIONS IN NAIROBI , KENYA

The rise and growth of fraud in MFI’s has been observed and can be explained through a model, which consists of three key factors: availability of opportunities, personal pressure, and the rationalization of the act. However, most micro finance institutions in Kenya face one problem; fraud. Locally, a number of studies have been carried out on fraud but most have concentrated on macro financial institutions and not Micro-finance institutions. The general objective was to evaluate the effect of fraud management strategies on performance of selected MFIs in Nairobi, Kenya. The research adopted a descriptive research design. The target population therefore comprised of 406 management employees of the MFIs. A sample population of 197 is arrived at by calculating the target population of 406 with a 95% confidence level and an error of 0.05. Stratified random sampling is unbiased sampling method of grouping heterogeneous population into homogenous subsets then making a selection within the individual subset to ensure representativeness. Descriptive statistics such as frequencies, percentages, mean score and standard deviation were estimated for all the quantitative variables and information presented inform of tables and graphs. Inferential data analysis was done using Pearson correlation coefficient and regression analysis (multiple regression analysis). Multiple regression analysis was used to establish the relations between the independent and dependent variables. The finding showed that anti-fraud strategy affects the performance of selected micro finance institution in Kenya to a great extent. According to the findings internal control influences performance of selected MFIs in Kenya to a great extent. The findings further indicated that fraud detection influences performance of selected MFIs in Kenya to a very great extent. The findings also noted that corporate governance influences performance of selected MFIs in Kenya to a very great extent. Based on the research findings the study concludes that anti-fraud strategy affects the performance of selected micro finance institution in Kenya. The study also concludes that internal control International Journal of Strategic Management Vol. 5 Issue 10 http://www.ijsse. org ISSN 2307-6305 Page | 79 influences performance of selected MFIs in Kenya. Study concludes that fraud detection influences performance of selected MFIs in Kenya. Finally, concludes that corporate governance influences performance of selected MFIs. Based on the research findings and conclusions the study recommends that management team of Micro finance institution in Kenya should adopt anti-fraud policies strategy in their organizations.