Miracle-dz/UniFAR-FTUs huggingface dataset:
Star formation and AGN activity in the most luminous LINERs in the local universe

This research was supported by the Junta de Andalucia through project TIC114, and the Spanish Ministry of Economy and Competitiveness (MINECO) through project AYA2013-42227-P. The work was also supported by the Israel Science Foundation grant 284/13. MP acknowledge financial support from JAE-Doc programme of the Spanish National Research Council (CSIC), co-funded by the European Social Fund.
Mental Accounting in Portfolio Choice: Evidence from a Flypaper Effect

Consistent with mental accounting, we document that investors sometimes choose the asset allocation for one account without considering the asset allocation of their other accounts. The setting is a firm that changed its 401(k) matching rules. Initially, 401(k) enrollees chose the allocation of their own contributions, but the firm chose the match allocation. These enrollees ignored the match allocation when choosing their own-contribution allocation. In the second regime, enrollees simultaneously selected both accounts' allocations, leading them to mentally integrate the two. Own-contribution allocations before the rule change equal the combined own- and match-contribution allocations afterwards, whereas combined allocations differ sharply across regimes.
Retrieval of tropospheric column-averaged CH4 mole fraction by solar absorption FTIR-spectrometry using N2O as a proxy

Abstract. Tropospheric column-averaged CH4 mole fractions were derived from ground-based column absorption measurements. The method uses stratospheric N2O columns to correct for the stratospheric contribution to the CH4 total column. The method was applied to four Total Carbon Column Observing Network (TCCON) sites covering locations from the Northern Arctic to the tropics. It performs well for all sites. The derived tropospheric CH4 concentrations were compared with profiles measured by aircraft at three sites. The results indicate an inter-site consistency within 6 ppb (~0.3%). With aircraft profiles up to 3 km, the seasonal behavior of the derived tropospheric CH4 concentration was also checked, revealing a difference of around 20 ppb. The mean relative uncertainty of the four sites, as estimated from the daily standard deviations, is 0.23%.
Baboons, Water, and the Ecology of Oxygen Stable Isotopes in an Arid Hybrid Zone

Baboons regularly drink surface waters derived from atmospheric precipitation, or meteoric water. As a result, the oxygen isotope (δ18O) composition of their tissues is expected to reflect that of local meteoric waters. Animal proxies of the oxygen isotope composition of meteoric water have practical applications as paleoenvironmental recorders because they can be used to infer aridity and temperature in historic and fossil systems. To explore this premise, we measured the δ18O values of hair from two baboon species, Papio anubis and Papio hamadryas, inhabiting Awash National Park, Ethiopia. The hybridizing taxa differ in their ranging behavior and physiological response to heat. Papio hamadryas ranges more widely in the arid thornbush and is inferred to ingest a greater proportion of leaf water that is enriched in 18O as a result of evaporative fractionation. It is also better able to conserve body water, which reduces its dependence on meteoric waters depleted in 18O. Taken together, these factors would predict relatively higher δ18O values in the hair (δ18Ohair) of P. hamadryas. We found that the δ18Ohair values of P. hamadryas were higher than those of P. anubis, yet the magnitude of the difference was marginal. We attribute this result to a common source of drinking water, the Awash River, and the longer drinking bouts of P. hamadryas. Our findings suggest that differences in δ18O values among populations of Papio (modern or ancient) reflect different sources of drinking water (which might have ecological significance) and, further, that Papio has practical value as a paleoenvironmental recorder.
Glucocorticoids Regulate Tristetraprolin Synthesis and Posttranscriptionally Regulate Tumor Necrosis Factor Alpha Inflammatory Signaling

ABSTRACT Glucocorticoids are used to treat various inflammatory disorders, but the mechanisms underlying these actions are incompletely understood. The zinc finger protein tristetraprolin (TTP) destabilizes several proinflammatory cytokine mRNAs by binding to AU-rich elements within their 3′ untranslated regions, targeting them for degradation. Here we report that glucocorticoids induce the synthesis of TTP mRNA and protein in A549 lung epithelial cells and in rat tissues. Dexamethasone treatment leads to a sustained induction of TTP mRNA expression that is abrogated by RU486. Glucocorticoid induction of TTP mRNA is also blocked by actinomycin D but not by cycloheximide, suggesting a transcriptional mechanism which has been confirmed by transcription run-on experiments. The most widely characterized TTP-regulated gene is the AU-rich tumor necrosis factor alpha (TNF-α) gene. Dexamethasone represses TNF-α mRNA in A549 cells and decreases luciferase expression of a TNF-α 3′ untranslated region reporter plasmid in an orientation-dependent manner. Small interfering RNAs to TTP significantly prevent this effect, and a cell line stably expressing a short-hairpin RNA to TTP conclusively establishes that TTP is critical for dexamethasone inhibition of TNF-α mRNA expression. These studies provide the molecular evidence for glucocorticoid regulation of human TTP and reflect a novel inductive anti-inflammatory signaling pathway for glucocorticoids that acts via posttranscriptional mechanisms.
Assume-guarantee reasoning for linear dynamical systems

The notion of simulation relation has been adopted from theoretical computing science to control theory to reduce the complexity arising in modeling physical processes. Simulations can serve as an abstraction of a given system behavior whilst preserving the input-output structure. We intend to apply simulation relations to develop a framework for compositional and assume-guarantee reasoning for linear dynamical systems. The underlying idea is to use information about the relation of components or subsystems to abstract the behavior of interconnected systems. The interconnection structure is hereby defined by two types of negative feedback.
Genetics of mondini malformation.

The Mondini malformation is a rare congenital inner ear malformation, characterized by cochlear abnormality with dilatation of the vestibule, aqueduct ampullar ends of the semicircular canals, and incomplete partition of the cochlea (1). These deformities may result in a perilymph fistula between subarachnoid space and the middle ear, which may result in cerebrospinal fluid (CSF) leakage, leading to rhinorrhea or otorrhea. CSF fistula can predispose affected individuals to recurrent meningitis. This abnormality happens due to arrest of cochlea development in seventh week of gestation and it is commonly associated with hearing impairment (2). The hearing loss is mainly sensorineural, but conductive hearing impairment due to CSF leakage or other disorders may accompany. Recurrent meningitis is the clue of diagnosis (3). There is a recent article, entitled “Recurrent bacterial meningitis in a child with hearing impairment, Mondini dysplasia: a case report”, published in the Acta Medica Iranica. We read this paper with great interest. The authors presented a case of recurrent meningitis who was referred for evaluating possible immunodeficiencies as the cause of recurrent meningitis. It should be noted that although primary immunodeficiency should be considered in the list of differential diagnosis in cases with recurrent serious infections, other underlying causes, particularly anatomical defects should be excluded (4). The presented patient had history of impaired hearing and recurrent bacterial meningitis, while computed tomography scan suggested Mondini malformation (5). Meantime no further investigations to genetically confirm the diagnosis was not made. Meantime no discussion was made on gene loci and indeed it is not clear how some other congenital syndromes, which could have been associated with this malformation, were excluded. It should be mentioned that some gene loci have been identified in association of this Mondini malformation. Mutations of the SLC26A4 gene have been found in individuals with enlargement of vestibular aqueduct or Mondini dysplasia. While several mutations have already been identified, IVS7-2A>G seems to be one of the most common one (6). SLC26A4 mutations cause both Pendred syndrome and DFNB4, which are two autosomal recessive disorders, commonly present with sensorineural hearing loss due to vestibular aqueduct enlargement or incomplete partition of cochlea (Mondini dysplasia) (7). TBX1 gene haploinsufficiency and point mutations can cause Di George syndrome, which could also be associated with Mondini dysplasia. Moreover some other congenital syndromes have been associated with this disorder, including Klippel-Feil syndrome and chromosomal trisomies (2). Considering such associations, providing genetic analysis and genetic counseling would be useful to exclude other syndromes, when Mondini dysplasia is suspected.
Fusing Recommendations for Social Bookmarking Web Sites

Social bookmarking Web sites are rapidly growing in popularity. Recommender systems, a promising remedy to the information overload accompanying the explosive growth in content, are designed to identify which unseen content might be of interest to a particular user, based on his or her past preferences. Most previous work in recommendation for social bookmarking suffers from lack of comparisons between the different available approaches. In this paper we address this issue by comparing and evaluating eight recommendation approaches on four data sets from two domains. We find that approaches that use tag overlap and metadata provide better results for social bookmarking data sets than the transaction patterns that are used traditionally in recommender systems research. In addition, we investigate how to fuse different recommendation approaches to further improve recommendation accuracy. We find that fusing recommendations can indeed produce significant improvements in recommendation accuracy. We also find that it is often better to combine approaches that use different data representations, such as tags and metadata, than to combine approaches that only vary in the algorithms they use. The best results are obtained when both of these aspects of the recommendation task are varied in the fusion process. Our findings can be used to improve the quality of recommendations not only on social bookmarking Web sites but conceivably also on Web sites that offer annotated commercial content.
Suberoylanilide hydroxamic acid (SAHA) has potent anti‐glioma properties in vitro, ex vivo and in vivo

Current treatment modalities for malignant gliomas do not allow long‐term survival. Here, we identify suberoylanilide hydroxamic acid (SAHA), an inhibitor of histone deacetylases (HDAC), as an effective experimental anti‐glioma agent. Administration of SAHA to various glioma cell lines obtained from human, rat and mouse inhibited tumour cell growth in a range of 1–10 μm. This anti‐glioma property is associated with up‐regulation of the cell cycle control protein p21/WAF, as well as the induction of apoptosis. A novel tumour invasion model using slice cultures of rat brain corroborated the anti‐glioma properties of SAHA in the organotypic brain environment. In this model, glioma invasion compromised adjacent brain parenchyma, and this tumour‐associated cytotoxicity could be inhibited by SAHA. In addition, a 10‐fold dose escalation experiment did not challenge the viability of cultured brain slices. In vivo, a single intratumoural injection of SAHA 7 days after orthotopic implantation of glioma cells in syngeneic rats doubled their survival time. These observations identify chromatin‐modifying enzymes as possible and promising targets for the pharmacotherapy of malignant gliomas.
NGFI‐B (Nurr77/Nr4a1) orphan nuclear receptor in rat pinealocytes: circadian expression involves an adrenergic‐cyclic AMP mechanism

NGFI‐B (Nur77/Nr4a1) is a member of a nuclear steroid receptor subgroup that includes the related factors Nurr1 (Nr4a2) and NOR‐1 (Nr4a3). These proteins do not have recognized ligands and in fact function independently as orphan receptors with transcriptional regulatory activity. In the present study, expression of the NGFI‐B gene in the rat pineal gland was found to exhibit a robust circadian rhythm, with elevated levels of NGFI‐B mRNA occurring at night. The rhythm of NGFI‐B mRNA is translated into a circadian rhythm of NGFI‐B protein, which accumulates in the nucleus of pinealocytes. In addition, there is a parallel marked nocturnal increase in pineal DNA binding activity to a NGFI‐B response element (NBRE, AAAGGTCA). Pharmacological studies indicate that NGFI‐B mRNA and protein levels are elevated via activation of adrenergic receptors. NGFI‐B protein levels are also elevated by dibutyryl cyclic AMP, as in other systems. In the pineal gland, regulation of NGFI‐B expression also involves the AP‐1 protein Fra‐2, based on studies with a transgenic Fra‐2 knockdown rat, in which pineal NGFI‐B expression increases. This set of observations extends the number of pineal genes that are known to be regulated by Fra‐2, and also provides the first indication that a member of the NGFI‐B group of nuclear receptors is involved in controlling gene expression in the pineal gland.
Antibodies to hepatitis C virus in uremic patients on continuous ambulatory peritoneal dialysis

The prevalence of antibody to hepatitis C virus (anti‐HCV) among 101 uremic patients receiving continuous ambulatory peritoneal dialysis (CAPD) was evaluated using a synthetic peptidebased HCV antibodies enzyme immunoassay. Thirty (29.7%) were found anti‐HCV positive. This is significantly higher than 500 unselected paid blood donors (4.2%, P < 0.0001). Among CAPD patients, anti‐HCV positivity was found more frequently in patients who had received frequent and longer duration of hemodialysis previously (40.4% vs. 20.4%, P < 0.05). These findings suggest that hemodialysis patients have a higher risk of HCV infection. At present, CAPD may be a suitable way to reduce the incidence of HCV infection in uremic patients.
ADOPTION OF HUMAN RESOURCE INFORMATION SYSTEMS INNOVATION IN PAKISTANI ORGANIZATIONS

A growing body of research is emphasizing the significance of adoption of technological innovation of Human Resources Information Systems (HRIS) to help modern organizations in effective management of human resources. However, there is lack of research on adoption of HRIS innovation in Pakistani context, there is available concern on different aspects of HRIS outside Pakistan. The purpose of this study was to identify the multiple factors contributing to organizational decision-making for the adoption of innovation of HRIS. This study examined relationship of six factors with adoption of innovation of HRIS in organizations: innovation factors of Relative Advantage, Compatibility, Complexity; organizational characteristics of support of Top Management & HRIS expertise, and environmental characteristic of Competition. For data collection, structured questionnaires were distributed for survey research and cross-sectional research design was adopted. Relative Advantage and Compatibility had positive relationship with HRIS adoption. However, Top Management Support and HRIS Expertise were found to be the top contributors to the decision of HRIS adoption. It was stated that introduction of new innovations in information systems could meet with organizational reluctance. The main cause was the complexity of new technology.
Dynamical evolution and chronology of the Hygiea asteroid family

The asteroid (10) Hygiea is the fourth largest asteroid of the main belt, by volume and mass, and it is the largest member of its own family. Previous works investigated the long-term effects of close encounters with (10) Hygiea of asteroids in the orbital region of the family, and analysed the taxonomical and dynamical properties of members of this family. In this paper we apply the high-quality Sloan Digital Sky Survey-Moving Object Catalog data, fourth release (SDSS-MOC4) taxonomic scheme of DeMeo & Carry to members of the Hygiea family core and halo, we obtain an estimate of the minimum time and number of encounter necessary to obtain a 3 sigma (or 99.7 per cent) compatible frequency distribution function of changes in proper a caused by close encounters with (10) Hygiea, we study the behaviour of asteroids near secular resonance configurations, in the presence and absence of the Yarkovsky force, and obtain a first estimate of the age of the family based on orbital diffusion by the Yarkovsky and Yarkovsky-O'Keefe-Radzievsky-Paddack (YORP) effects with two methods. The Hygiea family is at least 2 Byr old, with an estimated age of T = 3200(-120)(+380) Myr and a relatively large initial ejection velocity field, according to the approach of Vokrouhlicky et al. Surprisingly, we found that the family age can be shortened by similar or equal to 25 per cent if the dynamical mobility caused by close encounters with (10) Hygiea is also accounted for, which opens interesting new research lines for the dynamical evolution of families associated with massive bodies. In our taxonomical analysis of the Hygiea asteroid family, we also identified a new V-type candidate: the asteroid (177904) (2005 SV5). If confirmed, this could be the fourth V-type object ever to be identified in the outer main belt.
Pre-Monsoon Rain and Its Relationship with Monsoon Onset over the Indochina Peninsula

We analyzed rainfall during the pre-monsoon season from 1979 to 2002 over the Indochina Peninsula. Our multi-year analysis confirmed that the passage of the upper trough and moisture convergence in the lower troposphere produce intermittent rainfall events during the pre-monsoon season. From this result, three questions are raised. First, what are the characteristics of the upper trough? Second, what is the cause of the significant amount of moisture during the pre-monsoon season over inland Indochina? Third, what is the relationship between the intermittent pre-monsoon rainfall and monsoon onset? Our study suggests the following answers to these questions: 1) The upper trough is associated with the cyclone over the Yangtze River basin. This cyclone is baroclinic, so the upper trough over the study area is produced by the mid-latitude regime. 2) A significant amount of moisture over the Indochina Peninsula is produced by both intermittent rainfall associated with the passage of the upper trough and continuous rainfall occurred over a wide region associated with the equatorial southwesterly. 3) We found no clear relationship between rainfall amount during the pre-monsoon period and timing of monsoon onset over the Indochina Peninsula.
Methane Metabolism in a Temperate Swamp

Comparisons between in situ CH4 concentration and potential factors controlling its net production were made in a temperate swamp. Seasonal measurements of water table level and depth profiles of pH, dissolved CH4, CO2, O2, SO42-, NO3-, formate, acetate, propionate, and butyrate were made at two adjacent sites 1.5 to 2 m apart. Dissolved CH4 was inversely correlated to O2 and, in general, to NO3- and SO42-, potential inhibitors of methanogenesis. At low water table levels (August 1992), maximal CH4 (2 to 4 μM) occurred below 30 cm, whereas at high water table levels (October 1992) or under flooded conditions (May 1993), CH4 maxima (4 to 55 μM) occurred in the top 10 to 20 cm. Higher CH4 concentrations were likely supported by inputs of fresh organic matter from decaying leaf litter, as suggested by high acetate and propionate concentrations (25 to 100 μM) in one of the sites in fall and spring. Measurements of potential CH4 production (and consumption) showed that the highest rates generally occurred in the top 10 cm of soil. Soil slurry incubations confirmed the importance of organic matter to CH4 production but also showed that competition for substrates by nonmethanogenic microorganisms could greatly attenuate its effect.
Phase I study of docetaxel, oxaliplatin and capecitabine (TEX) as first line therapy to patients with advanced gastro-oesophageal cancer

Abstract Background. ECF (epirubicin, cisplatin, 5-FU) has been a standard first-line regimen in patients with advanced gastro-esophageal cancer (GEC). If cisplatin is substituted by oxaliplatin (Eloxatin®) – E) and 5-FU by capecitabine (X – Xeloda®) this regimen is easily administered with at least comparable efficacy and lower toxicity. Recent studies indicate that efficacy can be improved by adding docetaxel (Taxotere® – T) to CF. We initiated a phase I trial of T, short-time infusion of E and continuously X (TEX) as first-line therapy in GEC to establish the recommended dose (RD) for further therapy. Materials and methods. Patients were enrolled in cohorts of three at five dose levels. Patients had histologically confirmed GEC adenocarcinoma. Therapy was administered day 1 with escalating doses of docetaxel (60 mg/m2 to 75 mg/m2 iv as a 60 minutes infusion), oxaliplatin (85 to 130 mg/m2 iv as a 30 minutes infusion) and oral capecitabine (1 000 to 1 250 mg/m2/day). TEX was repeated every third week for a maximum of eight cycles. Toxicity was evaluated according to CTCAE v3.0 and dose limiting toxicity (DLT) was evaluated after the first course of TEX. Results. From June 2007 to April 2009, 23 consecutive patients received TEX. At dose level V, two of four patients experienced DLT and therefore we included additional seven patients at dose level IV. Only one of seven experienced DLT but dose-intensity was reduced to 75% in four of seven patients after three courses of TEX. Therefore we defined dose level III as RD. Efficacy was promising with response rate 38%, PFS 9.4 months and OS 12.5 months. Conclusion. The recommended dose of TEX (docetaxel 60 mg/m2 iv day 1, oxaliplatin 115 mg/m2 iv day 1 and oral capecitabine 1250 mg/m2/day continuously) every three weeks is easily administered in an out-patient setting. Efficacy is promising and will be evaluated in a phase II study.
Thermoregulation of protein synthesis in Borrelia burgdorferi

Borrelia burgdorferi, the etiological agent of Lyme disease, infects humans via the bite of a tick. The microbe survives in at least two vastly different environments: an arthropod vector and a warm-blooded host. We examined protein synthesis in B. burgdorferi B31 in response to sudden heat stress, which is similar to that which occurs during the transmission from vector to host. Proteins synthesized after shifts from 28 degrees C to higher temperatures and in pulse-chase experiments were labeled with 3H-labeled amino acids for 4 h and characterized by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and fluorography. The synthesis of four proteins we designated as heat stress proteins (HSPs) was increased by shifts to higher temperatures (HSP-1, 75 kilodaltons [kDa]; HSP-2, 42 kDa; HSP-3, 39 kDa; and HSP-4, 27 kDa); and the amount of one protein we designated as heat-labile protein 1 (29.5 kDa) was decreased at higher temperatures. At 37 to 40 degrees C, the major heat stress protein, HSP-1, represented 14 to 18% of the total cell protein compared with 1 to 2% of the total cell protein at 28 degrees C. HSP-1 was stable during a 4-h chase at either 40 or 28 degrees C. Demonstration of similar HSPs in low-passage, pathogenic strains of B. burgdorferi suggests that the heat stress response may be common among B. burgdorferi strains and may play a role in Lyme disease.