Miracle-dz/UniFAR-FTUs huggingface dataset:
InMAP: A model for air pollution interventions

Mechanistic air pollution modeling is essential in air quality management, yet the extensive expertise and computational resources required to run most models prevent their use in many situations where their results would be useful. Here, we present InMAP (Intervention Model for Air Pollution), which offers an alternative to comprehensive air quality models for estimating the air pollution health impacts of emission reductions and other potential interventions. InMAP estimates annual-average changes in primary and secondary fine particle (PM2.5) concentrations—the air pollution outcome generally causing the largest monetized health damages–attributable to annual changes in precursor emissions. InMAP leverages pre-processed physical and chemical information from the output of a state-of-the-science chemical transport model and a variable spatial resolution computational grid to perform simulations that are several orders of magnitude less computationally intensive than comprehensive model simulations. In comparisons run here, InMAP recreates comprehensive model predictions of changes in total PM2.5 concentrations with population-weighted mean fractional bias (MFB) of −17% and population-weighted R2 = 0.90. Although InMAP is not specifically designed to reproduce total observed concentrations, it is able to do so within published air quality model performance criteria for total PM2.5. Potential uses of InMAP include studying exposure, health, and environmental justice impacts of potential shifts in emissions for annual-average PM2.5. InMAP can be trained to run for any spatial and temporal domain given the availability of appropriate simulation output from a comprehensive model. The InMAP model source code and input data are freely available online under an open-source license.
Gene–environment interactions in the aetiology of systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a disease that displays a multitude of symptoms and a vast array of autoantibodies. The disease course may vary substantially between patients. The current understanding of SLE aetiology includes environmental factors acting on a genetically prone individual during an undetermined time period resulting in autoimmunity and finally surpassing that individual's disease threshold. Genetic differences and environmental factors may interact specifically in the pathogenetic processes and may influence disease development and modify the disease course. Identification of these factors and their interactions in the pathogenesis of SLE is vital in understanding the disease and may contribute to identify new treatment targets and perhaps also aid in disease prevention. However, there are several problems that need to be overcome, such as the protracted time frame of environmental influence, time dependent epigenetic alterations and the possibility that different pathogenetic pathways may result in a similar disease phenotype. This is mirrored by the relatively few studies that suggest specific gene-environment interactions. These include an association between SLE diagnosis and glutathion S-transferase gene variants combined with occupational sun exposure as well as variants of the N-acetyl transferase gene in combination with either aromatic amine exposure or hydralazine. With increased knowledge on SLE pathogenesis, the role of environmental factors and their genetic interactions may be further elucidated.
Codebook-Based Concatenating Precoder Search Strategies for Multi-Cell Joint Processing

In multi-cell joint processing, a concatenating precoder can be constructed and applied among multiple base stations (BS) to enhance the system performance. In practice, the precoder used by each BS is chosen from a pre-determined codebook. Exhaustive search (ES) could be employed for concatenating precoder construction, but the complexity of which might be too high for implementations, especially when the number of collaborative BS and the codebook size are large. In this paper, we present and study three alternative precoder search methods that can achieve similar performance to ES but with much lower complexities. The strengthes of these proposed schemes are illustrated clearly through computer simulations.
Morality and involvement in social virtual worlds: The intensity of moral emotions in response to virtual versus real life cheating

Our focus lies on moral emotions in the social virtual world Second Life (SL). Based on media equation theory we could expect that moral emotions regulate social virtual interactions in a similar way as they do in real life (RL). However, emotions are also linked with involvement, and SL residents presumably are more involved in SL compared to non-residents. Via two quasi-experiments, we tested to what extent moral emotions felt when being cheated on by a love partner are comparable in intensity when this happens in SL versus RL. Results show that for SL residents the intensity of moral emotions did not differ between SL versus RL situations, whereas for non-residents a SL situation triggered less intense emotions. Further, for SL residents the level of involvement in SL had a significant impact on the moral emotions in response to a SL situation. In social virtual worlds, media equation thus seems to depend on involvement.
Pneumonectomy with en bloc chest wall resection: is it worthwhile? Report on 34 patients from two institutions.

OBJECTIVES Pneumonectomy with en bloc chest wall resection is often denied because of the procedure-related high risk. We evaluated the short- and long-term outcome of this procedure. METHODS From January 1995 to October 2011, 34 patients (30 males and 4 females; mean age: 61.8 years) underwent pneumonectomy with en bloc chest wall resection for 33 non-small-cell lung cancer and 1 metastatic osteosarcoma in two institutions. Data were retrospectively reviewed. RESULTS Operative (30-day) mortality was 2.9% (1 of 34), and morbidity was 38.2% (13 of 34). There were 14 (41.1%) right-side procedures and 20 (58.8%) left-side procedures. Three (8.8%) patients developed bronchopleural fistulas. The mean number of resected ribs per patient was 2.7 ± 1.1. In 13 (38.2%) patients, a prosthetic reconstruction of the chest wall was needed. In 3 (8.8%) cases, the bronchial step was buttressed. Preoperative pain was statistically significantly related to the depth of chest wall invasion (P = 0.026). The N status was N0 in 18 (52.9%) cases, N1 in 9 (26.4%), N2 in 6 (17.6%) and Nx in 1 (metastatic osteosarcoma). Patients were followed-up for a total of 979 months. The median survival was 40 months. The overall 5-year survival was 46.8% (± 95% confidence interval [CI]: 0.2-0.6): 45.2 (± 95% CI: 0.03-0.8) for right-side and 48.4% (± 95% CI: 0.2-0.7) for left-side procedures, respectively. According to the N status, the 5-year survival was 59.7 (± 95% CI: 0.3-0.8) in N0, 55.5 (± 95% CI: 0.06-1) in N1 and 16.6% (± 95% CI: 0-0.4) in N2. The subgroup N0 plus N1 (27 patients) showed a 58.08% (± 95% CI: 0.3-0.8) 5-year survival compared with 16.6% (± 95% CI: 0-0.4) in N2 (χ(2): 3.7; P = 0.053). CONCLUSIONS Pneumonectomy with en bloc chest wall reconstruction can be safely offered to selected patients. The addition of en bloc chest wall resection to pneumonectomy does not affect operative mortality and morbidity compared with standard pneumonectomy. The pivotal additional effect of the chest wall resection should not be considered a contraindication for such procedures. Survival showed a clinically relevant difference by comparing N0 plus N1 with N2 (58.1 vs 16.6%), not confirmed by the statistical analysis (P = 0.053).
Economic evaluation of interventions for problem drinking and alcohol dependence: cost per QALY estimates.

AIMS To compare the performance of competing and complementary interventions for prevention or treatment of problem drinking and alcohol dependence. To provide an example of how health maximising decision-makers might use performance measures such as cost per quality adjusted life year (QALY) league tables to formulate an optimal package of interventions for problem drinking and alcohol dependence. METHODS A time-dependent state-transition model was used to estimate QALYs gained per person for each intervention as compared to usual care in the relevant target population. RESULTS Cost per QALY estimates for each of the interventions fall below any putative funding threshold for developed economies. Interventions for problem drinkers appear to offer better value than interventions targeted at those with a history of severe physical dependence. CONCLUSIONS Formularies such as Australia's Medicare should include a comprehensive package of interventions for problem drinking and alcohol dependence.
The natural history of tardive dystonia. A long-term follow-up study of 107 cases.

The clinical picture, risk factors and natural history of tardive dystonia resulting from dopamine-receptor antagonist (DRA) treatment in 107 patients (57 male and 50 female), seen between 1972 and 1995, are described. The mean age at onset (+/- SD) was 38.3 +/- 13.7 years (range 13-68 years), and the age at last follow-up was 46.3 +/- 15.7 years (range 15-80 years). These patients had received DRAs for schizophrenia (39%), for other psychiatric conditions (51.5%) and for non-psychiatric disorders (9.5%). All classes of neuroleptics used were implicated in producing tardive dystonia, which was found to develop at any time, ranging from 4 days to 23 years after their introduction (median 5, mean 6.2 +/- 5.1 years); there was no 'safe' period. Men were significantly younger than women at onset of dystonia, which developed after shorter exposure in men. At onset, the dystonia was focal in 83% of cases, but progressed over months or years and remained focal in only 17% at the time of maximum severity. The craniocervical region was involved in 87% of cases, and was the most commonly affected site both at onset and at maximum severity. There was a correlation between the site and age of onset; the site of onset ascended from the lower limbs to the face as the mean age of onset increased. Overall, the phenomenology of tardive dystonia was indistinguishable from that of primary (idiopathic) dystonia, although retrocollis and anterocollis, as well as torticollis to the right, were significantly more common in tardive dystonia. It is a very persistent disorder; only 14% of our patients had a remission over a mean follow-up period of 8.5 years. Remission occurred after a mean of 5.2 years from onset (range 1-12 years) and 2.6 years after discontinuation of neuroleptics (range 1 month to 9 years). Discontinuation of neuroleptics increased the chances of remission fourfold. Patients with < or = 10 years on neuroleptics had a five times greater chance of remission than those with > 10 years exposure, suggesting that the pathogenetic changes in tardive dystonia may become irreversible after long-term use of these drugs. None of the numerous treatments tried in these patients, including clozapine and botulinum toxin injections, seemed to relate to overall outcome, but there was a significant negative association between the occurrence of remission and the use of benzodiazepines. Although there were hints of a possible genetic predisposition, the question as to whether patients with tardive dystonia have an underlying vulnerability remains unanswered.
Rat Sperm 2B1 Glycoprotein (PH20) Contains a C-Terminal Sequence Motif for Attachment of a Glycosyl Phosphatidylinositol Anchor. Effects of Endoproteolytic Cleavage on Hyaluronidase Activity1

Abstract Rat sperm 2B1 antigen (the orthologue of guinea pig sperm PH20) is a plasma membrane-bound glycoprotein that is endoproteolytically cleaved during passage through the epididymis and subsequently migrates from the tail to the acrosomal domain during capacitation. Unlike guinea pig PH20, however, sperm surface 2B1 is insensitive to phosphatidylinositol phospholipase C, nor is it known how endoproteolytic cleavage affects its hyaluronidase activity. In this investigation we have expressed 2B1 cDNA in Chinese hamster ovary cells; we have shown that it contains an internal sequence motif for attachment of a glycosyl phosphatidylinositol (GPI) anchor and that cleavage from a single- into a two-chain molecule causes a significant shift in the optimum pH for hyaluronidase activity. Functionally, these results suggest that 1) 2B1 glycoprotein on rat spermatozoa is attached to the plasma membrane via a GPI anchor and that this is an important factor in its ability to migrate from the tail to the acrosomal domain during capacitation; and 2) endoproteolytic cleavage of 2B1 serves to optimize its hyaluronidase activity immediately before fertilization, thereby facilitating penetration of spermatozoa through the cumulus oophorus.
The absence of branched-chain amino acid and growth rate control at the internal ilvEp promoter of the ilvGMEDA operon

The question of whether the promoter ilvEp, located in the coding region of ilvM, the second structural gene in the ilvGMEDA operon, is subject to either amino acid- or growth rate-mediated regulation is examined. The experiments described here were performed with ilvEp-cat and ilvEp-lac fusions carried as single copies on the chromosome. The activity of the ilvEp promoter was found to respond neither to the availability of branched-chain amino acids nor to a wide range of growth rates between 35 to 390 min. In the absence of any known role for the products of the ilvGMEDA operon when repressing levels of branched-chain amino acids are present, there appears to be only a gratuitous role for the transcription at ilvEp.
Contingent Negative Variation under Competitive Situations

Participants high and low in competitiveness completed a reaction-time task with a warning stimulus designed to elicit contingent negative variation, competing on reaction speed with a visible or invisible opponent to identify what affects contingent negative variation amplitude under more critical competitive situations. For participants low in competitiveness, contingent negative variation was larger and reaction time (RT) was shorter when winning a trial and competing with a visible opponent. For those high in competitiveness, contingent negative variation was larger under competitive situations with a visible opponent than with an invisible one, although no difference was found in RT. These findings suggest that contingent negative variation amplitude under competitive situations reflects not only motor preparation but also other psychological processes such as awareness of an opponent.
Bis(2,2′-bipyridine N,N′-dioxide)bis(tricyanomethanido)manganese(II)

In the title complex, [Mn(C4N3)2(C10H8N2O2)2], the MnII atom lies on an inversion center and is coordinated by two 2,2′-bipyridine N,N′-dioxide (dpdo) molecules and two tricyanomethanide (tcm) ligands to form a distorted octahedral geometry. Weak intermolecular C—H⋯O or C—H⋯N hydrogen bonds, involving either the O atom of the dpdo molecule and the pyridyl H atom, or the N atom of the tcm anion and the pyridyl H atom, result in the formation of a three-dimensional network structure.
A Robust Method for Quantitative High-throughput Analysis of Proteomes by 18O Labeling*

MS-based quantitative proteomics plays an increasingly important role in biological and medical research and the development of these techniques remains one of the most important challenges in mass spectrometry. Numerous stable isotope labeling approaches have been proposed. However, and particularly in the case of 18O-labeling, a standard protocol of general applicability is still lacking, and statistical issues associated to these methods remain to be investigated. In this work we present an improved high-throughput quantitative proteomics method based on whole proteome concentration by SDS-PAGE, optimized in-gel digestion, peptide 18O-labeling, and separation by off-gel isoelectric focusing followed by liquid chromatography-LIT-MS. We demonstrate that the off-gel technique is fully compatible with 18O peptide labeling in any pH range. A recently developed statistical model indicated that partial digestions and methionine oxidation do not alter protein quantification and that variances at the scan, peptide, and protein levels are stable and reproducible in a variety of proteomes of different origin. We have also analyzed the dynamic range of quantification and demonstrated the practical utility of the method by detecting expression changes in a model of activation of Jurkat T-cells. Our protocol provides a general approach to perform quantitative proteomics by 18O-labeling in high-throughput studies, with the added value that it has a validated statistical model for the null hypothesis. To the best of our knowledge, this is the first report where a general protocol for stable isotope labeling is tested in practice using a collection of samples and analyzed at this degree of statistical detail.
High Current Density and Long-Life Nanocomposite Scandate Dispenser Cathode Fabrication

A nano-Sc<sub>2</sub>O<sub>3</sub>-added W powder for use in high current density thermionic cathodes has been made using a solution-gel method with the following controllable uniform average particle sizes: ~72, 146, 272, and 587 nm. Using these powders, nanostructured Sc<sub>2</sub>O<sub>3</sub> -added tungsten matrices with uniform nanosized tungsten grains and homogenous pore distribution were obtained. Nanocomposite Sc<sub>2</sub>O<sub>3</sub>-added W impregnated cathodes have been prepared from these powders and have shown excellent emission properties. For example, space-charge-limited current densities of 40 ± 1 A · cm<sup>-2</sup> at 850°C and 170 ± 5 A · cm<sup>-2</sup> at 1050°C have been obtained using a 300-nm Sc<sub>2</sub>O<sub>3</sub>-added (4.77 wt.%) W powder. Life testing is ongoing with 50 ± 2.5 A · cm<sup>-2</sup> current density emission demonstrated at 1050°C after 10 680 h.
A Side Order of Stem Cells: The SP Phenotype

A defining property of murine hematopoietic stem cells (HSCs) is low fluorescence after staining with Hoechst 33342 and Rhodamine 123. These dyes have proven to be remarkably powerful tools in the purification and characterization of HSCs when used alone or in combination with antibodies directed against stem cell epitopes. Hoechst low cells are described as side population (SP) cells by virtue of their typical profiles in Hoechst red versus Hoechst blue bivariate fluorescent‐activated cell sorting dot plots. Recently, excitement has been generated by the findings that putative stem cells from solid tissues may also possess this SP phenotype. SP cells have now been isolated from a wide variety of mammalian tissues based on this same dye efflux phenomenon, and in many cases this cell population has been shown to contain apparently multipotent stem cells. What is yet to be clearly addressed is whether cell fusion accounts for this perceived SP multipotency. Indeed, if low fluorescence after Hoechst staining is a phenotype shared by hematopoietic and organ‐specific stem cells, do all resident tissue SP cells have bone marrow origins or might the SP phenotype be a property common to all stem cells? Subject to further analysis, the SP phenotype may prove invaluable for the initial isolation of resident tissue stem cells in the absence of definitive cell‐surface markers and may have broad‐ranging applications in stem cell biology, from the purification of novel stem cell populations to the development of autologous stem cell therapies.
The role of contact allergy to aeroallergens in atopic dermatitis

In some patients with atopic dermatitis (AD), delayed‐type allergy to aeroallergens, such us house dust mite, can be demonstrated by patch testing. Positive patch tests can be expected only in patients with AD and, in them, only to aeroallergens to which type 1 reactions have also been demonstrated. In an as yet unknown number of such cases, aeroallergens appear lo play H role in AD. Studies to dale have varied too widely in experimental method and design to allow more definite conclusions 10 he drawn, It is essential that future studies are standardised with regard lo patch test system and designed to include adequate controls und assessment of relevance.
Effects of CIR selection diversity with two correlated branches in the m-fading channel

A number of methods for the measurement of channel impulse response (CIR) (desired signal carrier power to interference ratio) have been proposed in cellular mobile radio systems. The paper estimates the probability of cochannel interference for CIR selection diversity having two correlated branches in the m-fading channel. The advantage of CIR selection diversity over selection diversity based on the desired signal power algorithm is confirmed.
Utility of liquid‐based cytology for cervical carcinoma screening

In a study using a split‐sample design, liquid‐based cytology (ThinPrep® Processor, Cytyc Corporation, Boxborough, MA) was compared with the conventional Papanicolaou (Pap) smear in Guanacaste, Costa Rica. The study provides the first population‐based comparison of the ThinPrep® screening technology and includes “gold standard” measures of diagnostic accuracy.
Can problem‐based learning address content and process? *

Problem‐based learning was used to address the learning process and traditional content in a one semester nonmajors biochemistry course. Three different pedagogical strategies were evaluated in three versions of the course. The first version exclusively utilized literature‐based learning (analysis of primary literature articles in small groups) with almost no lectures from the instructor. Classroom assessment addressed the research process, not content. In the second version, literature‐based learning was supplemented with a 75‐min lecture by the instructor before each article was analyzed as well as additional lectures as deemed necessary. Classroom assessment addressed process (70%) over content (30%). The third version was lecture‐based, with the emphasis on traditional content; lectures were supplemented with literature analysis. Classroom assessment emphasized content, but about 10% of each exam focused on the research process. Student evaluations of the three versions of the course showed no significant difference in opinions about the format of the course. Postcourse interviews with students 1) confirmed previous studies that showed that the literature‐based format greatly increased the involvement of students in their own learning, 2) showed that literature‐based learning is compatible with an equal focus on content and process, and 3) showed that supplementing lecture‐based teaching with literature‐based learning does not empower students to manage their own learning, although student response to this instructional method was positive.
Pharmacokinetics and Absolute Bioavailability of Selegiline Following Treatment of Healthy Subjects With the Selegiline Transdermal System (6 mg/24 h): A Comparison With Oral Selegiline Capsules

The selegiline transdermal system is a monoamine oxidase inhibitor that was recently approved by the US Food and Drug Administration for the treatment of major depressive disorder. The current study was conducted during the selegiline transdermal system development program to characterize the single‐dose pharmacokinetics and absolute bioavailability of selegiline administered by the 6‐mg/24‐h selegiline transdermal system in healthy volunteers. Selegiline transdermal system results were compared with those obtained after a single 10‐mg oral dose of selegiline HCl. The selegiline pharmacokinetics differed greatly between the 2 routes of administration. Transdermal selegiline administration reduced metabolism and produced a high, sustained plasma selegiline concentration over the dosing period, with an absolute bioavailability of 73%. By contrast, oral dosing produced a sharp plasma selegiline peak that occurred within 1 hour and declined rapidly, with an absolute bioavailability of 4%. The data provide the basis for therapeutic advantages of the selegiline transdermal system in administering antidepressant doses of selegiline.