Miracle-dz/UniFAR-FTUs huggingface dataset:
Childhood Maltreatment, Limbic Dysfunction, Resilience, and Psychiatric Symptoms

Previous research has indicated that childhood maltreatment is predictive of psychiatric symptoms in adulthood. Among the potential intervening factors in this relationship are affective reactions in the victims, neurodevelopmental problems, and resilience. The purpose of this study was to test, in a nonclinical low-risk sample, an integrative developmentally based psychoneurological model of the roles of limbic system dysfunction, shame and guilt, and resiliency as potential intervening variables between childhood maltreatment and adult psychiatric symptoms. Also of interest was whether there were gender-specific pathways from maltreatment to symptoms. Based on the results of preliminary analyses, several regressions were conducted separately by gender, entering the different forms of parental aggression at Step 1, resilience at Step 2, the resilience by parental aggression interaction term at Step 3, shame and guilt at Step 4, and limbic dysfunction at Step 5, as predictors of psychiatric symptoms. Analyses indicated that both maternal psychological maltreatment and paternal physical maltreatment were predictive of total psychiatric symptomatology in adulthood, with shame mediating the relationship in women and guilt mediating it in men, limbic system symptoms mediating the relationship in both genders, and trait resilience moderating the relationship in both genders.
Post-surgical enterococcal meningitis: Clinical and epidemiological study of 20 cases

Enterococcal post-surgical meningitis is an uncommon disease. 20 episodes of nosocomial post-surgical enterococcal meningitis diagnosed between 1994 and 2003 were retrospectively studied. During the period of study 20 cases of post-surgical enterococcal meningitis (60% female, mean age 55±18 y, range 16–78 y) were reviewed. The mean time between admission at the hospital and surgery was 26 (SD = 15) d (range 7–61 d). The most frequent underlying diseases were: intracerebral haemorrhage (55%), brain neoplasms (25%), head trauma (15%) and hydrocephalus (5%). 11 patients had previously received antibiotic treatment. The isolates identified were Enterococcus faecalis (n = 18) (90%), E. faecium (1) and E. durans (1). 11 patients had polymicrobial infections. The treatment most frequently used was vancomycin alone or with other antibiotics (11). In 5 patients intrathecal vancomycin (20 mg/d) was also added. The mortality rate was not different in intrathecally treated patients. Cerebrospinal fluid (CSF) devices were removed in 8 patients. Four patients died due to the infection. Mortality was significantly associated with lack of removal of the CSF devices (p = 0.04). Enterococcal spp. are a cause of nosocomial meningitis associated with neurosurgical procedures and the presence of neurological devices.
Socio-Spatial Factors Affecting Household Recycling in Townhouses in Pretoria, South Africa

Although social factors affecting recycling have been widely researched, the effect of spatial and physical factors posed by medium-density housing, such as townhouses, is less understood. Using the Theory of Planned Behaviour, the relative effect of three sets of factors on household recycling in townhouses are examined, including ‘attitude’ (about recycling), ‘subjective norm’ (social pressure), and ‘perceived behaviour control’ (ability to recycle). A questionnaire survey of 300 households was conducted in Equestria, an enclosed middle-income residential estate consisting of several townhouse complexes. Confirmatory factor analysis verified the three factor measurement model for recycling participation. Both recyclers and non-recyclers showed positive attitudes toward recycling and felt social pressure to recycle. Non-recyclers, however, felt significantly less able to recycle. Most recyclers as well as non-recyclers indicated that certain proposals for increasing recycling may cause them to recycle more, in particular a system through which the management agency arranges access for a recycling company to collect recyclables from strategically located collection points inside the complex. Urban planning and design recommendations for facilitating recycling in townhouses are discussed.
Accidental Career Paths: An Exploration of the Lived Experiences of Professional Academic Advisors

VI LIST OF TABLES . X LIST OF FIGURES . XI CHAPTER 1: INTRODUCTION . 1 Purpose of the Study . 9 Significance of the Study . 11 CHAPTER 2: LITERATURE REVIEW . 14 History of Academic Advising . 14 Sociology of Professional Work . 23 Professional Standards in Academic Advising . 27 Academic Advisor Roles and Responsibilities . 32 Training Programs. 40 Summary . 46 CHAPTER 3: METHODOLOGY . 47 Narrative Inquiry . 47 Site and Participant Selection . 49 Data Collection . 55 ix Data Analysis . 57 Ethical Issues and Limitations . 59 CHAPTER 4: STUDY FINDINGS AND ANALYSIS . 63 Accidental Careers . 64 Advisor Training and Style Development . 69 Challenges and Motivators. 81 FLSA Implementation Challenges . 93 Discussion. 114 CHAPTER 5: CONCLUSION . 145 Advisors as Teachers and Learners . 145 The Missing Advisor Perspective . 146 An Institution of Silos . 148 Professional Identity through an Institutional Lens . 149 Recommendations . 151 Future Research . 161 APPENDIX . 164 Interview Protocol . 164 Participant Recruitment Letter . 167 Participant Recruitment Follow-up . 168 Participant Information Form . 169 BIBLIOGRAPHY . 171
Participation and health-related quality of life in adults with spastic bilateral cerebral palsy and the role of self-efficacy.

OBJECTIVE To assess participation and health-related quality of life in adults with bilateral spastic cerebral palsy, and explore associations with self-efficacy. DESIGN Cross-sectional study. SUBJECTS A sample of 56 adults with bilateral spastic cerebral palsy (mean age 36.4 (standard deviation 5.8) years; 62% male). METHODS Daily activities and social participation (Life Habits 3.0), health-related quality of life (SF-36 Health Survey), demographic and clinical characteristics, and self-efficacy (General Self-Efficacy Scale (GSES-12)) were assessed. Associations were studied using multivariate logistic regression analyses. RESULTS At least 60% of the sample had difficulties with mobility, recreation and housing, and 44% had difficulty with personal care and employment. They perceived low health-related quality of life for physical functions, but not for mental functions. Corrected for demographic and clinical characteristics, general self-efficacy explained 49% of the variance in outcome on social participation, and the subscale Effort (GSES-12) 32% of the variance for the physical health-related quality of life and 16% of the mental health-related quality of life. CONCLUSION A significant number of adults with bilateral spastic cerebral palsy encountered difficulties in social participation and had a low perceived health-related quality of life for physical functions. Higher general self-efficacy or a greater willingness to expend effort in achieving behaviour was related to better participation and a higher physical and mental health-related quality of life.
Expression and secretion of a prokaryotic protein streptokinase without glycosylation and degradation in Schizosaccharomyces pombe

Streptokinase (SK) is an important thrombolytic protein that is secreted by pathogenic strains of Streptococcus. Expression of streptokinase has been so far attempted in Pichia pastoris, Escherichia coli and Bacillus subtilis and shown to yield protein that was either highly glycosylated or degraded. Since the fission yeast, Schizosaccharomyces pombe, shares several molecular characteristics with higher eukaryotes, we decided to express the streptokinase gene in this yeast. A chimeric gene comprising the signal sequence of the Plus pheromone of Sz. pombe fused in‐frame with the mature streptokinase from Streptococcus sp. was constructed and inserted into the expression vector containing the thiamine‐regulated promoter. We obtained a high level of expression of streptokinase comparable to that in E. coli and P. pastoris, with 50–100% processing of the signal sequence and secretion of the mature streptokinase into the periplasmic fraction. The mature enzyme co‐migrates with the authentic mature SK in SDS gels, lacks any major modification and is functional. Importantly, a higher level of expression under stationary phase conditions and improved extractability of the mature and undegraded streptokinase was achieved in a novel mutant of Sz. pombe defective for a potent extracellular protease activity. We suggest that the unique vector/strain system developed here could be advantageous for large‐scale production of prokaryotic proteins without significant modification or degradation in Sz. pombe. Copyright © 2004 John Wiley & Sons, Ltd.
Urinary Antidiuretic Hormone Excretion during Mechanical Ventilation and Weaning in Man

The authors measured antidiuretic hormone (ADH) excretion, and renal and cardiovascular function in eight patients with flail chest during four ventilatory conditions: continuous positive-pressure ventilation (CPPV), intermittent positive-pressure ventilation (IPPV), spontaneous breathing with continuous positive airway pressure (CPAP) and spontaneous breathing (SB). Each condition was maintained for six to eight days. ADH excretion was significantly greater during CPPV (181 ± 14 ng/24 h, mean ± SE) than during IPPV (86 ± 10), CPAP (83 ± 7), and SB (44 ± 6). Free-water clearance was more negative during mechanical ventilation than during CPAP and SB, resulting in significant fluid retention during CPPV and IPPV (440 ± 88 and 547 ± 70 ml/day) and a negative water balance during SB (-154 ± 80 ml/ day). Arterial and central venous pressures and cardiac output (measured in four patients) did not change significantly among ventilatory conditions. It is concluded that ADH excretion is increased during CPPV, and this could represent one possible mechanism of water retention with this type of ventilation.
The lung in rheumatoid arthritis, cause or consequence?

Purpose of reviewRecent discoveries implicate the lungs as a possible extra-articular mucosal site for initiating rheumatoid arthritis-associated immunity. Recent findingsIndividuals at risk for developing arthritis and patients with early untreated rheumatoid arthritis show signs of lung involvement on high-resolution computer tomography. Rheumatoid arthritis-associated antibodies are present in patients with respiratory complains such as bronchiectasis and unexplained dyspnea even in the absence of joint disease and might predict future development of rheumatoid arthritis in these patients. Rheumatoid arthritis-associated antibodies are detected in the sputum of individuals at risk for developing rheumatoid arthritis but not yet having disease. Signs of bronchial mucosal inflammation with germinal center formation and local production of antibodies have been described in patients with early untreated rheumatoid arthritis. Shared antigenic targets have been identified and characterized in the lungs and joints of rheumatoid arthritis patients. SummaryRecent findings support an important role for the lung as a mucosal extra-articular place were inflammation induced by external triggers (such as smoking) leads to tolerance break and generation of rheumatoid arthritis-specific immunity already before disease onset with only secondary targeting of the joints.
Evaluation of the ability of a feed additive to ameliorate the adverse effects of aflatoxins in turkey poults

1. A study was conducted to evaluate the possible protective effect of a feed additive containing aluminosilicate and phytogenic substances against the adverse effects of aflatoxins in turkey poults. 2. Dietary treatments (6) were given to turkey poults from d 1 to d 42 of age. From d 1 to 21 the dietary treatments were as follows: 1, negative control, no aflatoxins or feed additive added; 2, feed additive control, 1 kg/t feed additive, no aflatoxins; 3, 250 ppb (µg/kg) aflatoxins, no feed additive; 4, 250 ppb aflatoxins + 1 kg/t feed additive; 5, 500 ppb aflatoxins, no feed additive; and 6, 500 ppb aflatoxins + 1 kg/t feed additive. From d 22 to 42, the dietary concentration of the feed additive was increased from 1 to 2 kg/t in all treatment groups receiving the feed additive (2, 4 and 6), while keeping constant the dietary concentrations of aflatoxins. 3. Aflatoxins at 250 ppb did not cause adverse effects on performance but affected certain toxicopathological parameters. At 500 ppb, adverse effects on performance and several toxicological parameters were observed. 4. Some of the adverse affects were partially or completely overcome by supplementation with the feed additive, including amelioration of the performance parameters, suppression of mortality and correction of the immunological alterations induced by the exposure to the aflatoxins.
In vivo adenovirus-mediated gene transfer of the Escherichia coli cytosine deaminase gene to human colon carcinoma-derived tumors induces chemosensitivity to 5-fluorocytosine.

To evaluate the concept that in vivo transfer of the Escherichia coli cytosine deaminase gene will confer sensitivity of a solid tumor to the prodrug 5-fluorocytosine (5FC), we constructed an adenovirus vector (AdCMV.CD) carrying the cytosine deaminase gene driven by the cytomegalovirus (CMV) promoter, infected HT29 colon carcinoma cells in vitro and in vivo, and evaluated cell growth over time. AdCMV.CD produced a functional cytosine deaminase protein in HT29 cells in vitro as evidenced by the ability of lysates from the infected cells to convert [3H]5FC to its active metabolite 5-fluorouracil (5FU). The AdCMV.CD vector effectively suppressed HT29 cell growth in vitro in the presence of 5FC in a dose-dependent manner. Infection with AdCMV.CD, when as few as 10% of cells expressed the cytosine deaminase gene, was associated with a bystander effect when combined with 5FC in cell mixing studies. Further, this bystander effect was not dependent on cell-to-cell contact as demonstrated by suppression of [3H]thymidine incorporation in HT29 cells when supernatant from AdCMV.CD-infected cells treated with 5FC was transferred cells. Consistent with these in vitro observations, when AdCMV.CD was directly injected into established subcutaneous HT29 tumors in nude mice receiving 5FC, there was a four-fold reduction in tumor size at day 15 compared to controls, and a five-fold reduction at day 28. These observations suggest that adenovirus-mediated gene transfer of the E. coli cytosine deaminase gene and concomitant administration of 5FC may have potential as a strategy for local control of the growth of tumor cells susceptible to 5FU.
Beyond gambling: mediating roles of brand experience and attitude

Purpose The purpose of this paper is to explore the effect of customers’ perception of the integrated resort by focusing on brand-related variables, namely, brand reputation, brand experience, brand attitude, and behavioral intention. Integrated resorts have become popular in the tourism industry. However, despite the popularity of integrated resorts, little is known about how the integrated resort brand contributes to customer attitude. Design/methodology/approach A descriptive online survey was carried out with customers who had experience using the integrated resort. This study used the regression analysis and process macro to test hypothesized relationships among variables. Findings These results demonstrate that brand reputation increases customers’ perception of brand experience and brand attitude; brand experience, brand attitude and brand reputation affect behavioral intention toward the integrated resort brand; and brand experience and attitude plays a fully mediating role in the relationship between brand reputation and behavioral intention. These results suggest that customers’ perception associated with the integrated resort brand name is likely to generate a favorable experience and attitude, which, in turn, develops customers’ revisit intention. Research limitations/implications A theoretical implication is that the pleasant brand experience and attitude emphasize the significance of the brand reputation in the formation of behavioral intention toward the integrated resort brand. Another theoretical implication is that integrated resort brand reputation might not be a strong indicator of the behavioral loyalty. It is worth conducting additional research on joint effects of brand reputation and customers’ type (e.g. recreational gamblers, problem gamblers, business travelers and family travelers). Practical implications The findings offer additional insights into managers on the integrated resort brand concept. This research provides opportunities for managers to identify rational/emotional linkages in differentiating, distinguishing and positioning integrated resort. Originality/value Although both brand experience and brand attitude have received past research attention, no researchers have studied them in an integrated resort setting. The main contribution of this research lies in testing the direct and indirect and fills a major gap in the integrated resort literature and research in stressing the need to consider about brand management.
Prenatal Drug Exposure Moderates the Association between Stress Reactivity and Cognitive Function in Adolescence

Prenatal drug exposure (PDE) can undermine subsequent health and development. In a prospective longitudinal study we examine whether PDE moderates the link between stress reactivity and cognitive functioning in adolescence. Participants were 76 prenatally drug-exposed and 61 nonexposed (NE) community comparison African American youth (50% male, mean age 14.17 years) living in an urban setting. All participants completed neuropsychological and academic achievement tests (Children's Memory Scales, the California Verbal Learning Test - Children's version and the Wide Range Achievement Test 4) over the course of 1 day in a laboratory setting. Two mild stressors (Balloon Analog Risk Task - Youth and Behavioral Indicator of Resilience to Distress) were administered, with saliva samples (assayed for cortisol) collected pre- and poststress task. A higher percentage in the NE group, compared to the PDE group (26% vs. 12%, χ2 = 4.70, d.f. = 1, n = 137, p = 0.03), exhibited task-related increases in salivary cortisol. PDE moderated the association between stress reactivity and 11 of 15 cognitive performance scales. In each case, the NE stress reactive group had better cognitive performance than either the NE lower cortisol reactive group or the PDE group regardless of stress reactivity status. Stress-related reactivity and regulation of the hypothalamic-pituitary-adrenal axis in adolescence may be disrupted by PDE, and the disruption may be linked to lower cognitive performance.
The prevalence of asthma and heart disease in transport workers: a practice-based study.

BACKGROUND There has been widespread concern that the increasing incidence of asthma observed during the late 1980s might have arisen because of environmental pollution, and in particular vehicle pollution. The General Practice Morbidity Survey in 1991/92 (MSGP4) collected data on occupation, employment status, and smoking habit linked individually to each patient record. OBJECTIVES To examine whether people with occupations that have high exposure to vehicle exhaust fumes have an increased prevalence of asthma, acute respiratory infections, and ischaemic heart disease (IHD). METHOD Men aged 16 to 64 years were grouped by Standard Occupational Classification codes; 93,692 employed and 20,858 not-employed men were studied separately. Those with likely high occupational exposure were grouped together ('all-exposed')--the remainder occupations in corresponding chapters of the code were used as controls. We compared 12-month age and smoking standardised disease prevalence ratios for asthma, chronic obstructive pulmonary disease (COPD), acute respiratory infections (IHD), and all circulatory disorders in the all exposed and individual exposed occupations with their matching controls. Also the mean frequency of consultations per person consulting was calculated for each occupational group and disease. RESULTS For employed persons, the prevalence ratio (PR) for asthma in the all-exposed, (116, 95% confidence interval [95% CI] = 101-130) exceeded that for all employed persons (100); however, the difference compared with chapter-matched controls (PR = 97, 95% CI = 92-103), was not statistically significant. Results for COPD were similar. Prevalence ratios in motor mechanics, a high-exposure group, were 98 (95% CI = 70-127) 96 (95% CI = 70-123) for asthma and COPD respectively. Among the employed, prevalence ratios for IHD in all but one of the individual occupation groups examined did not differ from the average, however among those not employed the ratio in the all-exposed (PR = 152, 95% CI = 128-174) exceeded that in the controls (PR = 112, 95% CI = 104-120). CONCLUSION Occupational groups exposed to motor vehicle pollution have a marginally increased prevalence of asthma compared with working males generally, though not compared with occupation matched controls. This study has demonstrated a methodology for using GP data to examine occupation-related disease. This could be used in future by augmenting GP data with occupation and smoking information.
Quality assurance programme for drug susceptibility testing of Mycobacterium tuberculosis in the WHO/IUATLD Supranational Reference Laboratory Network: five rounds of proficiency testing, 1994-1998.

SETTING Quality assurance for the WHO/IUATLD Global Tuberculosis Drug Resistance Surveillance Programme. OBJECTIVE To implement an ongoing proficiency-testing programme for drug susceptibility testing (DST) of Mycobacterium tuberculosis within the WHO/IUATLD Supranational Reference Laboratories Network (SRLN). DESIGN Five culture panels, each consisting of 10 duplicate drug-susceptible and drug-resistant clinical isolates (100 strains) of M. tuberculosis were tested for resistance to streptomycin (SM), isoniazid (INH), rifampicin (RMP) and ethambutol (EMB). DST procedures included the proportion, absolute concentration and resistance ratio methods, as well as the radiometric BACTEC 460 method. RESULTS The efficiency, sensitivity and specificity of M. tuberculosis DST as well as the intra-laboratory reproducibility showed that the laboratories tested susceptibility to RMP and to INH very reliably, with values ranging from 97% to 99%. The testing of SM and EMB was less dependable, with values ranging from 90% to 95%. The sensitivity of testing of EMB increased from 60% in Round 1 to 98% in Round 5, without a concomitant decrease in specificity. CONCLUSIONS This study has shown that regular proficiency testing can significantly improve the quality of DST, even in the most sophisticated TB laboratories. Mean DST efficiency levels of 92% for both SM and EMB and 97% and 99% for INH and RMP, respectively, are proposed as reasonable performance goals for the SRL network. Efficiency, consistently lower than these values, would require remedial action. Efficiency levels lower than mean -1 standard error, i.e., 80% for SM and EMB, 89% for INH and 95% for RMP, should always be considered as sub-standard performance for DST.