Miracle-dz/UniFAR-FTUs huggingface dataset:
ANALISIS PENGARUH TINGKAT INFLASI, SUKU BUNGA SBI, NILAI TUKAR US DOLLAR PADA RUPIAH, JUMLAH UANG BEREDAR, INDEKS DOW JONES, INDEKS NIKKEI 225, DAN INDEKS HANGSENG TERHADAP PERGERAKAN INDEKS HARGA SAHAM GABUNGAN (IHSG) PERIODE TAHUN 2010-2014

To know the influence of inflation, certificates of Indonesia Bank interest rate, the exchange rate of US dollar in the rupiah, money supply, Dow Jones, Nikkei 225 and Hang Seng Index towards movements price in The Jakarta Composite Exchange (JKSE) in the period 2010-2014. The population used is the price of Jakarta Composite Exchange (JKSE) on the Indonesia Stock Exchange period 2010-2014. The sample is priced of Jakarta Composite Exchange (JKSE) on the Indonesia Stock Exchange were selected by total sampling method. This type of data is data documentary. Source data is using data secondary. Data collection methods is documentation techniques. Methods of analysis using descriptive statistical analysis, multiple regression analysis, quality test data, and the coefficient of determination. The results showed the exchange rate of US dollar in the rupiah and the Dow Jones significantly influenced The Jakarta Composite Exchange (JKSE). The inflation rate, certificates of Indonesia Bank interest rate, money supply, Nikkei 225 and Hang Seng Index does not significantly influenced The Jakarta Composite Exchange (JKSE). Keywords : Inflation, certificates of Indonesia Bank interest rate, the exchange rate of US dollar in the rupiah, money supply, Dow Jones, Nikkei 225 and Hang Seng Index towards movements price in The Jakarta Composite Exchange (JKSE)
Political Determinants Of Corporate Governance Political Context Corporate Impact

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Assessing Reliability and Validity of the Farsi Version of the Toronto Alexithymia Scale in a Sample of Substance-Using Patients

The aim of this study was to estimate reliability and factorial validity of the Farsi version of the Toronto Alexithymia Scale–20 (TAS–20) for 321 substance-abusing patients (187 men and 134 women). All were asked to complete the Farsi version of the Toronto Alexithymia Scale–20, the Emotional Intelligence Scale, and The Mental Health Inventory. Analysis supported the internal consistency, test-retest reliability, concurrent validity, and three-factor structure of the Farsi version of the TAS–20 for substance users. The factors are similar to the three reported previously and were labeled as Difficulty Identifying Feelings, Difficulty Describing Feelings, and Externally oriented Thinking. These results provide evidence for applicability of the TAS–20 and its cross-cultural validity
Neonatal hyperviscosity association with lower achievement and IQ scores at school age.

A longitudinal study was conducted to determine whether the early neurologic and motor impairment observed in children with neonatal polycythemia and hyperviscosity persisted into school age. Forty-nine children who had neonatal polycythemia and hyperviscosity were evaluated at a mean age of 7 years. Of these, 21 (group 1) received a partial plasma exchange transfusion, whereas 28 (group 2) received symptomatic care. Forty control children (group 3) with a normal neonatal hematocrit were also evaluated. Testing consisted of a battery of measures to evaluate IQ, achievement, neuromotor function, and gross and fine motor skills. Maternal education and IQ were also assessed to avoid potential confounding by differences in the home environment. The neonatal course of the children with polycythemia and hyperviscosity was characterized by an increased number of problems, including hypoglycemia and cyanosis. At 7 years of age, the 49 children who had hyperviscosity (groups 1 and 2) had significantly lower "spelling" and arithmetic achievement test results and gross motor skill scores. Scores for reading, visual motor integration, and neurologic signs did not differ significantly from group 3. Maternal IQ scores were similar for both groups. Left-hand preference was seen in 14% of group 1 and 2 children and 7% of group 3 children (not significant). The scores for IQ, achievement, neuromotor function, and visual motor integration were compared for the hyperviscosity group (groups 1 and 2) and the control group (group 3) by multivariate analysis of variance with sex and hyperviscous group as independent variables and maternal education and maternal IQ as covariates (P = .040). (ABSTRACT TRUNCATED AT 250 WORDS)
Tumor Infiltrating Regulatory T Cells: Tractable Targets for Immunotherapy

Several studies have linked tumor-infiltration by regulatory T cells with poor patient outcome. Targeting the mechanisms by which regulatory T cells traffic to and persist in the tumor may circumvent tumor immune-escape by de-restricting T cell-mediated cytotoxicity. In this review, we describe the principle axes that govern regulatory T cell migration and the mechanisms that underpin their immunosuppressive activity in cancer. Inhibiting either the migration or function of regulatory T cells may enhance host-anti-cancer immune responses and as such are attractive and tractable targets for therapeutic intervention.
Systematic Limited Arbitrage and the Cross-Section of Stock Returns: Evidence from Exchange Traded Funds

We propose a parsimonious, comprehensive proxy for innovations in limited arbitrage: innovations in ETFs’ premium. Consistent with a common component, we confirm limited arbitrage factors, LAFs, constructed from ETFs’ premium innovations spanning four asset classes are correlated. Further, we find that equity LAFs are negatively priced in the cross-section of stock returns. Our pricing tests also confirm that LAFs provide pricing information beyond well-known limits of arbitrage: illiquidity and idiosyncratic volatility. Overall, our findings suggest that limited arbitrage risk is priced and LAF is a relevant risk-factor.
Drought response strategies define the relative contributions of hydraulic dysfunction and carbohydrate depletion during tree mortality.

Plant survival during drought requires adequate hydration in living tissues and carbohydrate reserves for maintenance and recovery. We hypothesized that tree growth and hydraulic strategy determines the intensity and duration of the 'physiological drought', thereby affecting the relative contributions of loss of hydraulic function and carbohydrate depletion during mortality. We compared patterns in growth rate, water relations, gas exchange and carbohydrate dynamics in three tree species subjected to prolonged drought. Two Eucalyptus species (E. globulus, E. smithii) exhibited high growth rates and water-use resulting in rapid declines in water status and hydraulic conductance. In contrast, conservative growth and water relations in Pinus radiata resulted in longer periods of negative carbon balance and significant depletion of stored carbohydrates in all organs. The ongoing demand for carbohydrates from sustained respiration highlighted the role that duration of drought plays in facilitating carbohydrate consumption. Two drought strategies were revealed, differentiated by plant regulation of water status: plants maximized gas exchange, but were exposed to low water potentials and rapid hydraulic dysfunction; and tight regulation of gas exchange at the cost of carbohydrate depletion. These findings provide evidence for a relationship between hydraulic regulation of water status and carbohydrate depletion during terminal drought.
Transcriptional modulation of the developing immune system by early life social adversity

To identify molecular mechanisms by which early life social conditions might influence adult risk of disease in rhesus macaques (Macaca mulatta), we analyze changes in basal leukocyte gene expression profiles in 4-mo-old animals reared under adverse social conditions. Compared with the basal condition of maternal rearing (MR), leukocytes from peer-reared (PR) animals and PR animals provided with an inanimate surrogate mother (surrogate/peer reared, SPR) show enhanced expression of genes involved in inflammation, cytokine signaling, and T-lymphocyte activation, and suppression of genes involved in several innate antimicrobial defenses including type I interferon (IFN) antiviral responses. Promoter-based bioinformatic analyses implicate increased activity of CREB and NF-κB transcription factors and decreased activity of IFN response factors (IRFs) in structuring the observed differences in gene expression. Transcript origin analyses identify monocytes and CD4+ T lymphocytes as primary cellular mediators of transcriptional up-regulation and B lymphocytes as major sources of down-regulated genes. These findings show that adverse social conditions can become embedded within the basal transcriptome of primate immune cells within the first 4 mo of life, and they implicate sympathetic nervous system-linked transcription control pathways as candidate mediators of those effects and potential targets for health-protective intervention.
Rising taurine and ethanol concentrations in nucleus accumbens interact to produce dopamine release after ethanol administration

We have previously demonstrated that glycine receptors in the nucleus accumbens (nAc) are involved in modulating both basal and ethanol‐induced dopamine output in the same brain region. Ethanol is known to induce a release of both taurine and dopamine in the nAc, but the relationship between these two neuromodulators has not been investigated thoroughly. In vivo microdialysis was used to measure the effects of systemic ethanol diluted in isotonic (0.9% NaCl) or hypertonic (3.6% NaCl) saline on accumbal taurine and dopamine levels. We found that ethanol given in a hypertonic solution, contrary to an isotonic solution, failed to increase concentrations both of taurine and dopamine in the nAc. However, a modest, non‐dopamine elevating concentration of taurine in the nAc disclosed a dopamine‐elevating effect of systemic ethanol also when given in a hypertonic solution. In a second experiment, we investigated the effects of ethanol on taurine and dopamine in normal rats and rats with decreased levels of endogenous taurine. Lowering the level of taurine, approximately 40% by adding 5% β‐alanine in the drinking water, did not influence taurine or dopamine output over time. We conclude that the elevations of taurine and dopamine in the nAc are closely related, and that in order for ethanol to induce dopamine release, a simultaneous increase of extracellular taurine levels in the nAc is required. These data also provide support for the notion that the nAc is the primary target for ethanol in its dopamine‐activating effect after systemic administration.
Connections of the subthalamic nucleus with ventral striatopallidal parts of the basal ganglia in the rat

The present study was undertaken to establish the precise anatomical relationship of the subthalamic nucleus (STh) with limbic lobe‐afferented parts of the basal ganglia in the rat. The anterograde tracer Phaseolus vulgaris‐leucoagglutinin (PHA‐L), injected in the STh, the globus pallidus, the ventral pallidum, the ventral striatum, and the parafascicular thalamic nucleus, and the retrograde tracers Fluoro‐Gold (FG) and cholera toxin B (CTb), injected in the globus pallidus, the ventral pallidum, the ventral striatum, and the ventral mesencephalon, were used for this purpose. The results of these tracing experiments confirm the general notion of reciprocal connections between the STh and pallidal areas. Thus the dorsomedial part of the STh is connected with the subcommisural ventral pallidum, whereas a more ventral and lateral part of the medial STh is related to the medial globus pallidus. The lateral hypothalamic area, directly adjacent to the STh, containing neurons with a morphology quite similar to those in the STh, projects to parts of the ventral pallidum related to the olfactory tubercle. The reciprocal projection from this pallidal area to subthalamic regions appears to be very sparse. The medial STh sends strong projections to the medial part of the entopeduncular nucleus and the adjacent lateral hypothalamic area. Sparser projections from the medial STh reach the rostral and medial part of the caudate‐putamen and the nucleus accumbens. The nucleus accumbens. The nucleus accumbens sends a very sparse projection back to the medial STh. The projections of the medial STh to the ventral mesencephalon appear also to be topographically organized. The lateral hypothalamus and a few cells in the most medial part of the STh project to the ventral tegmental area, whereas progressively more lateral parts of the ventral mesencephalon, in particular the substantia nigra, receive input from successively more lateral and caudal parts of the STh. In addition, a number of STh fibers reach the midbrain extrapyramidal area. The lateral part of the parafascicular thalamic nucleus projects to the lateral part of the STh, whereas parafascicular neurons medial to the fasciculus retroflexus projects to the dorsomedial portion of the STh.
A Pdx-1-Regulated Soluble Factor Activates Rat and Human Islet Cell Proliferation

ABSTRACT The homeodomain transcription factor Pdx-1 has important roles in pancreas and islet development as well as in β-cell function and survival. We previously reported that Pdx-1 overexpression stimulates islet cell proliferation, but the mechanism remains unclear. Here, we demonstrate that overexpression of Pdx-1 triggers proliferation largely by a non-cell-autonomous mechanism mediated by soluble factors. Consistent with this idea, overexpression of Pdx-1 under the control of a β-cell-specific promoter (rat insulin promoter [RIP]) stimulates proliferation of both α and β cells, and overexpression of Pdx-1 in islets separated by a Transwell membrane from islets lacking Pdx-1 overexpression activates proliferation in the untreated islets. Microarray and gene ontology (GO) analysis identified inhibin beta-B (Inhbb), an activin subunit and member of the transforming growth factor β (TGF-β) superfamily, as a Pdx-1-responsive gene. Overexpression of Inhbb or addition of activin B stimulates rat islet cell and β-cell proliferation, and the activin receptors RIIA and RIIB are required for the full proliferative effects of Pdx-1 in rat islets. In human islets, Inhbb overexpression stimulates total islet cell proliferation and potentiates Pdx-1-stimulated proliferation of total islet cells and β cells. In sum, this study identifies a mechanism by which Pdx-1 induces a soluble factor that is sufficient to stimulate both rat and human islet cell proliferation.
Optimal Transmission Policies for Two-User Energy Harvesting Device Networks With Limited State-of-Charge Knowledge

This paper considers a wireless network composed of a pair of sensors powered by energy harvesting devices (EHDs), which transmit data to a receiver over a shared wireless channel. At any given time, based on the energy levels of the two rechargeable batteries of the sensors, a central controller (CC) decides on the amount of energy to be drawn from the two batteries and used for transmission. The problem considered is the maximization of the long-term average reward associated with data transmission, by optimizing the transmission strategy of the two nodes, in the case of a collision channel model and both i.i. d. and correlated energy arrivals. In addition, contrary to the traditional assumption that the amount of energy available to the sensors can be easily estimated, we derive the optimal policy in the cases where the state of charge (SOC) may not be perfectly known by the central controller, analyzing the performance degradation caused by this imperfect knowledge of the SOC. For this second scenario, supposing that the CC is only aware that each SOC is “LOW” or “HIGH,” we show that the impact of imperfect knowledge decreases with the two battery capacities and is negligible in most cases of practical interest.
Identification of Apocalmodulin and Ca2+-Calmodulin Regulatory Domain in Skeletal Muscle Ca2+ Release Channel, Ryanodine Receptor*

Fusion proteins and full-length mutants were generated to identify the Ca2+-free (apoCaM) and Ca2+-bound (CaCaM) calmodulin binding sites of the skeletal muscle Ca2+ release channel/ryanodine receptor (RyR1). [35S]Calmodulin (CaM) overlays of fusion proteins revealed one potential Ca2+-dependent (aa 3553–3662) and one Ca2+-independent (aa 4302–4430) CaM binding domain. W3620A or L3624D substitutions almost abolished completely, whereas V3619A or L3624A substitutions reduced [35S]CaM binding to fusion protein (aa 3553–3662). Three full-length RyR1 single-site mutants (V3619A,W3620A,L3624D) and one deletion mutant (Δ4274–4535) were generated and expressed in human embryonic kidney 293 cells. L3624D exhibited greatly reduced [35S]CaM binding affinity as indicated by a lack of noticeable binding of apoCaM and CaCaM (nanomolar) and the requirement of CaCaM (micromolar) for the inhibition of RyR1 activity. W3620A bound CaM (nanomolar) only in the absence of Ca2+ and did not show inhibition of RyR1 activity by 3 μm CaCaM. V3619A and the deletion mutant bound apoCaM and CaCaM at levels compared with wild type. V3619A activity was inhibited by CaM with IC50∼200 nm, as compared with IC50 ∼50 nm for wild type and the deletion mutant. [35S]CaM binding experiments with sarcoplasmic reticulum vesicles suggested that apoCaM and CaCaM bind to the same region of the native RyR1 channel complex. These results indicate that the intact RyR1 has a single CaM binding domain that is shared by apoCaM and CaCaM.
Emergency department anaphylaxis: A review of 142 patients in a single year.

BACKGROUND There are few data on the incidence, clinical features, and management of patients with acute anaphylaxis presenting to the emergency department. We investigated all presentations to one department during the course of a year to improve current awareness of this medical emergency. OBJECTIVE The purpose of the study was to describe the clinical features, management, and outcome of anaphylaxis presentations to a single Australian adult emergency department in a single year, 1998-1999. METHODS This was a retrospective, case-based study of adult patients (>or=13 years of age) attending a single emergency department in Brisbane, Australia, during the year 1998-1999. The medical records of 304 patients satisfying the relevant discharge diagnostic codes were studied. We determined incidence, sex ratio, age, clinical features, management, disposal, asthma prevalence, and causes in patients presenting with acute allergic reactions and anaphylaxis. RESULTS In all, 162 emergency department patients with acute allergic reactions and 142 emergency department patients with anaphylaxis, including 60 whose anaphylaxis was severe, were seen during the year, for an anaphylaxis presentation incidence of 1 in 439. One patient died; this gave a case fatality rate of 0.70%. Cutaneous features were present in 94% of the patients with anaphylaxis. Of those with severe anaphylaxis, 35% had dizziness/syncope before hospital presentation, 25% laryngeal edema, and 21.7% systolic hypotension on hospital presentation. A cause was recognized in 73% of the anaphylaxis cases; most commonly, the causative agent was a drug, insect venom, or food. Adrenaline was used in 57% of the severe cases before hospital presentation or in the hospital. The emergency department alone definitively cared for 94% of all patients, though only 43% severe anaphylaxis cases were referred for follow-up. CONCLUSION The emergency department anaphylaxis presentation incidence of 1 in 439 cases is greater than previously recognized, though death remains rare. In three fourths of cases, a precipitant was identified, a fact that emphasizes the need for a detailed initial history. Definitive management in the emergency department alone is possible in most cases, provided that the appropriate use of adrenaline and the need for allergy clinic follow-up are appreciated.
NGF induces neurite outgrowth via a decrease in phosphorylation of myosin light chain in PC12 cells

The relationship between phosphorylation of myosin light chain (MLC) and neurite outgrowth induced by nerve growth factor (NGF) was studied in PC12 cells. Inhibitors of Rho kinase, HA- 1077 or Y-27632 also induced neurite outgrowth. As already reported botulinum exoenzyme C3 which inactivates Rho protein also induced neurite outgrowth. Calyeulin A, an inhibitor of phosphatase counteracted both NGF- and C3- induced neurite outgrowth. Treatments of both NGF and C3 resulted in significant and transient decrease in phosphorylated MLC. These results suggest that NGF induces neurite outgrowth of PC12 by a transient decrease in phosphorylated MLC which is brought about by activation of MLC phosphatase via inhibition of Rho–Rho kinase pathway.
Mechanical stretching behavior simulation of SWCNT and SWCNT-Ni

When one-dimensional single atom chain was placed at the center of single wall carbon nano-tube (SWCNT) along the axis, and using the molecular dynamics simulation, the mechanical strength of a single-walled could be obtained in terms of the stress-strain curve. At this temperature of 0K, the ultimate stress of a SWCNT with one-dimensional single atom chain was higher than that of a SWCNT without this chain structure, and the result was reverse at 300K. With regard to the rupture of SWCNT, it can be observed that the SWCNT without single atom chain yielded more easily than the decorated SWCNT. The rupture of SWCNT was initiated at the location of distortion, which was introduced by thermal fluctuation and the interference of metal atoms. With the temperature rising, the SWCNT with or without atom Ni will be more likely to fracture. At last, for investigating the influence of increasing atom chains on the mechanical properties of the SWCNT, multi atom chains structure was also used in implementing the same simulation.
Innovation and Productivity : The Role of Public Support †

Research and innovation are widely agreed to be major driving forces behind long-term productivity and economic growth. However, the relationships have proven to be difficult to quantify. We make reference to the international literature and draw on recent research for Australia to advance our understanding of these relationships. Particular focus is on assessing the impact of publically financed R&D on productivity. The conclusions have implications for government innovation policies, providing insight into possible productivity gains from funding reallocations. Specifically, the findings suggest that government research agencies and higher education are areas in which investment leads to more potential productivity gains.