Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessing risk of neurodevelopmental disorders after birth with oxytocin: a systematic review and meta-analysis

Abstract Experts have raised concerns that oxytocin for labor induction and augmentation may have detrimental effects on the neurodevelopment of children. To investigate whether there is the reason for concern, we reviewed and evaluated the available evidence by searching databases with no language or date restrictions up to 9 September 2018. We included English-language studies reporting results on the association between perinatal oxytocin exposure and any cognitive impairment, psychiatric symptoms or disorders in childhood. We assessed the quality of studies using the Newcastle–Ottawa Quality Assessment Scales. Independent risk estimates were pooled using random-effects meta-analyses when at least two independent datasets provided data on the same symptom or disorder. Otherwise, we provided narrative summaries. Two studies examined cognitive impairment, one examined problem behavior, three examined attention-deficit/hyperactivity disorder (ADHD) and seven focused on autism spectrum disorders (ASD). We provided narrative summaries of the studies on cognitive impairment. For ADHD, the pooled risk estimate was 1.17; 95% confidence interval (CI) 0.77–1.78, based on a pooled sample size of 5 47 278 offspring. For ASD, the pooled risk estimate was 1.10; 95% CI 1.04–1.17, based on 8 87 470 offspring. Conclusions that perinatal oxytocin increases the risks of neurodevelopmental problems are premature. Observational studies of low to high quality comprise the evidence-base, and confounding, especially by the genetic or environmental vulnerability, remains an issue. Current evidence is insufficient to justify modifying obstetric guidelines for the use of oxytocin, which state that it should only be used when clinically indicated.
Role of the tissue-type plasminogen activator -7351C > T and plasminogen activator inhibitor 1 4G/5G gene polymorphisms in central serous chorioretinopathy

ABSTRACT Background: Central serous chorioretinopathy (CSC) is a common chorioretinal disease, characterized by choroidal hyperpermeability leading to neurosensory and/or retinal pigment epithelial detachments. Hypofibrinolysis due to higher plasma concentrations of plasminogen activator type 1 (PAI-1) or lower activity of tissue-type plasminogen activator (t-PA) has been implicated in the pathogenesis of CSC. Functional polymorphisms in the PAI-1 (SERPINE1) and t-Pa (PLAT) are thus potential risk factors for CSC. The aim of the present study was therefore to investigate a hypothesized association between the PAI-1 4G/5G and the t-PA -7351C > T gene variants and the presence of CSC. Methods: The present study comprised 172 CSC patients and 313 control subjects. Genotypes of the PAI-1 4G/5G and the t-PA -7351C > T polymorphisms were determined by TaqManTM fluorogenic 5′-exonuclease assays. Results: Allelic frequencies or genotype distributions of neither the PAI-1 4G/5G nor the t-PA -7531C > T polymorphisms were significantly different between patients with CSC and control subjects (PAI-1 4G/4G: 24.4% vs. 20.4, p = 0.36; t-PA -7351CC: 42.4% vs. 46.0%, p = 0.50). After adjusting for age and gender presence of the PAI-1 4G/4G genotype was associated with a non-significant odds ratio (OR) of 1.21 (95% confidence interval [95% CI]: 0.77–1.92, p = 0.41), while homozygosity for the t-PA -7351C allele yielded a non-significant OR of 0.91 (95% CI: 0.62–1.33, p = 0.62) for CSC. Conclusion: The present study suggests that both the t-PA -7351C > T and the PAI-1 4G/5G gene variants are unlikely major risk factors for CSC.
Spectrum and Prevalence of Pathogenic Variants in Ovarian Cancer Susceptibility Genes in a Group of 333 Patients

Constitutional loss-of-function pathogenic variants in the tumor suppressor genes BRCA1 and BRCA2 are widely associated with an elevated risk of ovarian cancer (OC). As only ~15% of OC individuals carry the BRCA1/2 pathogenic variants, the identification of other potential OC-susceptibility genes is of great clinical importance. Here, we established the prevalence and spectrum of the germline pathogenic variants in the BRCA1/2 and 23 other cancer-related genes in a large Polish population of 333 unselected OC cases. Approximately 21% of cases (71/333) carried the BRCA1/2 pathogenic or likely pathogenic variants, with c.5266dup (p.Gln1756Profs*74) and c. 3700_3704del (p.Val1234Glnfs*8) being the most prevalent. Additionally, ~6% of women (20/333) were carriers of the pathogenic or likely pathogenic variants in other cancer-related genes, with NBN and CHEK2 reported as the most frequently mutated, accounting for 1.8% (6/333) and 1.2% (4/333) of cases, respectively. We also found ten pathogenic or likely pathogenic variants in other genes: 1/333 in APC, 1/333 in ATM, 2/333 in BLM, 1/333 in BRIP1, 1/333 in MRE11A, 2/333 in PALB2, 1/333 in RAD50, and 1/333 in RAD51C, accounting for 50% of all detected variants in moderate- and low-penetrant genes. Our findings confirmed the presence of the additional OC-associated genes in the Polish population that may improve the personalized risk assessment of these individuals.
Semantic information, autonomous agency and non-equilibrium statistical physics

Shannon information theory provides various measures of so-called syntactic information, which reflect the amount of statistical correlation between systems. By contrast, the concept of ‘semantic information’ refers to those correlations which carry significance or ‘meaning’ for a given system. Semantic information plays an important role in many fields, including biology, cognitive science and philosophy, and there has been a long-standing interest in formulating a broadly applicable and formal theory of semantic information. In this paper, we introduce such a theory. We define semantic information as the syntactic information that a physical system has about its environment which is causally necessary for the system to maintain its own existence. ‘Causal necessity’ is defined in terms of counter-factual interventions which scramble correlations between the system and its environment, while ‘maintaining existence’ is defined in terms of the system's ability to keep itself in a low entropy state. We also use recent results in non-equilibrium statistical physics to analyse semantic information from a thermodynamic point of view. Our framework is grounded in the intrinsic dynamics of a system coupled to an environment, and is applicable to any physical system, living or otherwise. It leads to formal definitions of several concepts that have been intuitively understood to be related to semantic information, including ‘value of information’, ‘semantic content’ and ‘agency’.
Molecular insight to influential role of Hha–TomB toxin–antitoxin system for antibacterial activity of biogenic silver nanoparticles

Abstract Emergence of silver nanoparticles (AgNPs) as a potent antibacterial agent for clinical application has raised attention towards its mode of action and needs detailed understanding of the mechanism. The current study investigates the influential role of Hha–TomB toxin–antitoxin system in determination of AgNPs antibacterial activity. AgNPs were synthesized by biogenic process using bacterial supernatant and were characterized for their physiochemical properties. Microbiological and computational assays like molecular docking, growth curve analysis, live/dead assay, oxidative stress and apoptosis assay were performed with wild type (WT) and mutants (Δhha, ΔtomB) strains treated with AgNPs for elucidation of mechanism. Stable AgNPs having size 30–40 nm and zeta potential –32 ± 09 mV were synthesized. AgNPs have shown significant antibacterial activity against S. typhimurium. Influential role of Hha–TomB TA proteins was observed in antibacterial effect by their altered expression level change in ROS level and programmed cell death. Molecular investigation elucidated the effect of AgNPs as consequence of their interaction with cellular proteins with different amino acids via hydrophobic interaction leading to alteration of cellular metabolic processes like ROS induction and apoptosis causing ultimate death. The study provided a detail illustration of Hha–TomB TA system influence on antibacterial mechanism of AgNPs for wide spectrum clinical application.
Severe allergic contact dermatitis in a detergent production worker caused by exposure to methylisothiazolinone

Methylisothiazolinone (MI) is a preservative commonly used in paints, detergents and cosmetics. It has been found to be a potent sensitizer. During the recent years there has been an epidemic increase in allergic contact dermatitis caused by MI (1). We present the case of a worker in the detergent production industry who developed severe allergic contact dermatitis following occupational exposure to MI, illustrating the need for attention to occupational exposure to MI in the production setting, where high concentrations of MI are used.
An Overview of Postgraduate Thesis within the Field of Pre-School Education in Turkey (2002-2011)

Bu calismanin amaci, Turkiye'de okul oncesi egitimi alaninda yapilan lisansustu tezlerin incelenmesidir. Bu baglamda son on yil icerisinde yapilan 77 lisansustu tezi cesitli acilardan gruplandirilmistir. Bu arastirma, nitel bir arastirma olup veriler dokuman incelemesi teknigiyle toplanmistir. Arastirmanin orneklemi amacsal ornekleme stratejilerinden biri olan olcut ornekleme ile belirlenmistir. Ulasilan tezleri incelemek uzere arastirmacilar tarafindan calismanin amacina yonelik bir "Tez Inceleme Formu" gelistirilmistir. Verilerin cozumlenmesinde frekans ( f )'dan yararlanilmis ve grafikler uzerinde gosterilmistir. Arastirma sonucunda okul oncesi egitim alaninda on farkli universiteden toplam 77 tezin yurutuldugu, tezlerde calisma grubunun siklikla cocuklar oldugu, nitel arastirma tekniklerinin yogun olarak kullanildigi, tanimlayici ve fark istatistiklerinden faydalanildigi, tezlerin buyuk bir bolumunun herhangi bir destek alinmadan yapildigi ve calisma alani olarak Turkiye genelinde cok az sayida ilde calismalarin yurutuldugu sonuclarina ulasilmistir.
Animal Welfare and Mountain Products from Traditional Dairy Farms: How Do Consumers Perceive Complexity?

Simple Summary European consumers recognize the added value of mountain dairy production and relate it to a composite of positive attributes. However, while consumers’ understanding of conventional dairy production and animal welfare has already been investigated, how consumers perceive animal welfare in traditional mountain dairy farming remains unexplored. This qualitative study aims at shedding light on consumers’ perceptions regarding animal welfare in mountain dairy cheese production systems. Focus group interviews were carried out with three major consumer groups that purchase mountain cheese including rural consumers living in mountain villages, urban consumers living in the plains, and urban consumers living in mountain cities. The results of this study show that all participants expect mountain farming to be on a smaller scale and mountain products to be healthier when compared to non-mountain farming systems. However, the verbal appreciation of certain husbandry and management choices especially in the case of urban consumers did not result in their recognition when pictures of traditional husbandry systems were provided, which displays a disconnection between the expectations towards mountain production systems and reality. These findings will support the development of a transparent science-based dialogue among mountain dairy chain actors on animal welfare and sustainable farming practices in mountain areas. Abstract This qualitative study aims to investigate consumers’ perceptions toward dairy cow welfare in traditional mountain farms. While consumers’ understanding of conventional dairy production and animal welfare has already been investigated, how consumers perceive animal welfare in traditional mountain dairy farming remains still unexplored. Focus group interviews were conducted with consumers having different degrees of geographical proximity to mountains and with an explicit interest in local dairy products. The results of this qualitative study show that participants expect mountain farming to be on a smaller scale when compared to non-mountain farming systems and expect mountain products to be healthier. Similarly, all participants consider origin, locality, and small-scale production as relevant quality attributes of mountain cheese. However, the appreciation of these abstract features did not necessarily result in their recognition when sample pictures of traditional husbandry systems were provided especially in the case of urban participants. This study contributes to reveal the gap between urban consumers’ conception of mountain farming and the actual farming practices. It also indicates the need to promote an effective science-based dialogue on animal welfare that goes beyond an anthropomorphic perspective and tackles the complexity of farming systems in relation to the context in which they are located.
Degradation of Triclosan and Carbamazepine in Two Agricultural and Garden Soils with Different Textures Amended with Composted Sewage Sludge

Composted sewage sludge (CSS) has been extensively used in agriculture and landscaping, offering a practical solution for waste disposal. However, some pharmaceutical and personal care products (PPCPs) like triclosan (TCS) and carbamazepine (CBZ) have restricted its land application. In this study, CSS was added to agricultural soil and garden soil at 0%, 5%, 10%, and 25% (w/w soil), and 4 mL of TCS and CBZ stock solution (1000 mg/L in methanol) was spiked into soil amended with CSS of each bottle to arrive at the concentration of 10 mg/kg. Samples were then collected after incubation for 120 days and analyzed for concentrations and half-life (t1/2) of TCS and CBZ, and soil physicochemical properties, together with enzyme activities. The results showed that TCS was degraded completely during the incubation period. In contrast, only about 5.82–21.43% CBZ was degraded. CSS amendment inhibited TCS and CBZ degradation and prolonged t1/2 compared to the control, and the t1/2 of TCS and CBZ increased with CSS addition amount in all treatments except for CBZ in the garden soil amended with 10% CSS. Correlation studies showed a significantly positive relationship between t1/2 of TCS and CBZ and total organic carbon (TOC), while a significantly negative relationship between t1/2 of the two PPCPs and pH was observed. Alkaline phosphatase showed a significantly negative relationship with the Ct/C0 of TCS in garden soil amended with 25% CSS and CBZ in the control. The urease activity was negatively correlated with the Ct/C0 of TCS in 10% and 25% CSS treatments and CBZ in 10% CSS treatment for garden soil.
Exploring the genetic correlations of antisocial behaviour and life history traits

Prior evolutionary theory provided reason to suspect that measures of development and reproduction would be correlated with antisocial behaviors in human and non-human species. Behavioral genetics has revealed that most quantitative traits are heritable, suggesting that these phenotypic correlations may share genetic etiologies. We use GWAS data to estimate the genetic correlations between various measures of reproductive development (N= 52,776 – 318,863) and antisocial behavior (N= 31,968). Our genetic correlation analyses demonstrate that alleles associated with higher reproductive output (number of children ever born, rg=0.50, p=.0065) were positively correlated with alleles associated with antisocial behavior, whereas alleles associated with more delayed reproductive onset (age of first birth, rg=-.64, p=.0008) were negatively associated with alleles linked to antisocial behavior. Ultimately, these findings coalesce with evolutionary theories suggesting that increased antisocial behaviors may partly represent a faster life history approach, which may be significantly calibrated by genes.
Occupational health disparities among U.S. long-haul truck drivers: the influence of work organization and sleep on cardiovascular and metabolic disease risk

Objective The organization of work has undergone vast transformations over the past four decades in the United States and has had profound impacts on worker health and wellbeing. The profession of commercial truck driving is one of the best examples. Particularly for long-haul truck drivers, changes in work organization have led to disproportionately poor physiological, psychological, and sleep health outcomes. Methods The present study examined disparities in cardiometabolic disease risk among long-haul truck drivers and the general population, and the influence of work organization and sleep in generating these outcomes. Researchers collected survey data from 260 drivers, and blood assay samples from 115 of those drivers, at a large highway truck stop in North Carolina. Comparisons were made for cardiovascular and metabolic risk against the 2011–2012 National Health and Nutrition Examination Survey (NHANES). In addition, logistic regression was used to explore predictive relationships between work organization and sleep and risk for cardiovascular and metabolic disease. Results There were statistically significant mean differences between the long-haul truck driver sample and the NHANES sample for both cardiovascular (3.71 vs. 3.10; p <0.001) and metabolic (4.31 vs. 3.09; p <0.001) disease risk. The truck driver sample was less physically active and had lower HDL cholesterol along with greater levels of smoking, BMI, and metabolic syndrome diagnosis. More years of driving experience and poor sleep quality were statistically significant predictors for both cardiovascular and metabolic disease risk. Conclusions Study findings implicate elements of the occupational milieu experienced by long-haul truck drivers that induce disproportionate cardiometabolic disease risk. Sleep quality, largely compromised by poor work conditions and workplace environments, plays a significant role in increased risks for cardiometabolic disease. There is an urgent need for longitudinal studies of this critical occupational sector as well as intervention research centered on policy and systems level change.
Incumbents as disruptor and their disruptive behaviour enabling disruptive innovation: case study of high performance and low cost CPU and foundry market

ABSTRACT The ability and role of incumbents to enable and sustain disruptive innovation is underestimated so far, compared with new entrants. Thus, this research aimed to observe incumbents’ role as a disruptor and their disruptive behaviours to enable disruptive innovation in different market segments. Based on two case studies of CPU and foundry markets, it was observed that incumbents enabled disruptive innovation by adjusting disruptive window in the context of performance trajectories and discontinuous time, and they sustained their market leadership by having advantages through continuous cost reduction and accumulated technological knowledge in high performance and low cost market. This study has extended the theory of disruptive innovation by including incumbents’ role and their disruptive behaviours and has practical implications as well for incumbents and new entrants to establish competitive technology strategy at the organisation as well as national level.
An intravenous insulin protocol designed for pregnancy reduces neonatal hypoglycaemia following betamethasone administration in women with gestational diabetes

Marked hyperglycaemia is common following betamethasone administration in women with gestational diabetes (GDM), and may contribute to neonatal hypoglycaemia. Validated protocols to deliver glycaemic stability following betamethasone are lacking. We hypothesized that an intravenous insulin (IVI) protocol for pregnancy‐specific glycaemic targets (Pregnancy‐IVI) would achieve greater at‐target glycaemic control than a generic adult intravenous insulin protocol (Adult‐IVI), and may reduce neonatal hypoglycaemia.
Respiratory syncytial virus hospitalization in children in northern Spain

Objectives Understanding respiratory syncytial virus (RSV) morbidity may help to plan health care and future vaccine recommendations. We aim to describe the characteristics and temporal distribution of children diagnosed with RSV admitted in a Spanish hospital. Methods Descriptive study for which the hospital discharges of children < 5 years of age with RSV infection were analyzed. The information was extracted from the hospital discharge database of a reference pediatric hospital in northern Spain for the 2010–2011 to 2014–2015 RSV seasons. Results Six hundred and forty-seven hospitalizations of children with RSV infection were analyzed, 94% of which occurred between the second week of November and the last week of March. Most children (72%) were under one year of age and 95% were previously healthy infants. Infants born from October to December had the highest risk of hospitalization in the first year of life. The median length of hospital stay of children with and without comorbidities was six and three days, respectively. 6.5% of the hospitalized cases were admitted to the pediatric intensive care unit; this percentage was higher among children < 2 months (adjusted odds ratio 4.15; 95% confidence interval: 1.37–12.61) or with comorbidities (adjusted odds ratio 4.15; 95% confidence interval: 1.53–11.28). The case lethality was 0.3%. Conclusions The risk of hospitalizations for RSV is high during the first year of life and increases among infants born in the fall. Being under two months of age and presenting comorbidities are the main risk factors associated to pediatric intensive care unit admission.
Variations in contents of hyaluronan in the peritumoral micro‐environment of human chondrosarcoma

A concept consolidated in recent years is that tumor growth depends to a great extent on the micro‐environment surrounding the tumor, which has a fundamental role in tumor progression and in determining the effectiveness of therapies. Our analysis focuses on chondrosarcoma, the second primary malignant bone tumor, resistant to both chemotherapeutic and radiation therapy. We quantified hyaluronan, one of the main components of the extracellular matrix, with the aim of comparing its amount in the connective tissue surrounding the tumor with intra‐tumoral tissue and healthy fascia of the same anatomic district, viewed as a health control. We demonstrate that hyaluronan increased significantly in the peritumoral stroma compared with the healthy fascia, which showed an average amount according to the physical characteristics of body districts by a mean value of 26.9 μg/g. In the peritumoral stroma, the mean hyaluronan content reached 132.6 μg/g (mean value of 63.2 μg/g). The p‐value was less than 0.01, showing a highly significant statistical difference. Surprisingly, no significant differences were detected as a function of age, gender, or tumor grade. The levels of hyaluronan were comparable in peritumoral and tumor tissues, although there were differences depending on the state of necrosis. In addition, data on the expression of hyaluronic acid synthetase showed a decrease of about 50% in peritumoral and tumor tissues, indicating alterations in hyaluronan turnover and synthesis. This work demonstrates a variation in hyaluronan contents around the chondrosarcoma, likely correlated with the aggressiveness and resistance to chemotherapy of this tumors. Statement of Clinical Significance: Deeper knowledge about the composition of the peritumoral stroma, rich in extracellular matrix, will enhance better study and understanding of the metastatic potential of tumors and their prognostic indices. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:503–509, 2019.