Miracle-dz/UniFAR-FTUs huggingface dataset:
High But Not Low ECS Stimulus Intensity Augments Apomorphine-Stimulated Dopamine Postsynaptic Receptor Functioning in Rats

Background Clinical research shows that the antidepressant and cognitive adverse effects of electroconvulsive therapy are both dependent on the administered electrical stimulus intensity (dose); however, dose-dependent neurotransmitter system changes in the brain, which might underlie the therapeutic or adverse effects, remain to be demonstrated. Objective We used a behavioral model to examine dose-related effects of electroconvulsive shock (ECS) on dopamine postsynaptic receptor functioning in the rat brain. Methods In a factorially designed study, rats (n = 100) were treated with five once-daily ECSs at three levels (sham ECS, 30 mC ECS, and 120 mC ECS), and with drug at two levels (saline, and 1 mg/kg s.c. apomorphine). Motility was assessed in the small open field. Results Apomorphine-elicited, dopamine postsynaptic receptor-mediated hypermotility was significantly increased by 120 mC ECS but not by 30 mC ECS. An additional but unrelated finding was that, while the ECS seizure duration expectedly decreased across time, no dose-dependent effects were observed. Conclusion ECS-induced dopamine postsynaptic receptor up-regulation may depend on the intensity of the administered electrical stimulus.
GROWTH HORMONE RESPONSE TO GROWTH HORMONE RELEASING FACTOR IN DIABETIC MEN

Increased plasma concentrations of growth hormone (GH) are reported in diabetes and it is suggested that this may be important in the development of complications. We have investigated fasting GH levels and the response to 100 μg i.v. growth hormone releasing factor, GRF(1‐29)NH2, in age‐matched men: six normal weight controls, six obese controls, six insulin‐dependent diabetics, six normal weight non‐insulin dependent diabetics and six obese non‐insulin dependent diabetics. None of the diabetic men had clinical evidence of diabetic complications. Fasting GH values did not differ significantly between the five groups. The peak GH response to GRF was similar in the controls, insulin‐dependent diabetics (IDD) and non‐insulin dependent (NIDD) normal weight diabetics (mean peak±SEM: controls 25.5 ± 5 mU/1, IDD 26‐5 + 6 mU/1, NIDD 19.7 ± 5 mU/1) but was significantly reduced in the two obese groups (obese 6.4 ± 3mU/l, obese diabetics 4.5 ± 1 mU/1, P<001). This impairment of GH secretion was unrelated to either fasting plasma insulin or glucose concentration. We conclude that our results do not confirm the previous reports of abnormal GH secretion in diabetes but do demonstrate a markedly impaired GH response to GRF to be a feature of obesity.
A Recently Active Miniature Inverted-Repeat Transposable Element, Chunjie, Inserted Into an Operon Without Disturbing the Operon Structure in Geobacter uraniireducens Rf4

Miniature inverted-repeat transposable elements (MITEs) are short DNA transposons with terminal inverted repeat (TIR) signals and have been extensively studied in plants and other eukaryotes. But little is known about them in eubacteria. We identified a novel and recently active MITE, Chunjie, when studying the recent duplication of an operon consisting of ABC transporters and a phosphate uptake regulator in the chromosome of Geobacter uraniireducens Rf4. Chunjie resembles the other known MITEs in many aspects, e.g., having TIR signals and direct repeats, small in size, noncoding, able to fold into a stable secondary structure, and typically inserted into A + T-rich regions. At least one case of recent transposition was observed, i.e., the insertion of Chunjie into one copy of the aforementioned operon. As far as we know, this is the first report that the insertion of a MITE does not disrupt the operon structure.
Public Perspectives on Returning Genetics and Genomics Research Results

Background: The debate about returning research results has revealed different perspectives among researchers, participants and advisory groups with participants generally interested in obtaining their results. Given this preference, policies regarding return of individual research results may affect whether a potential subject chooses to participate in a study. Public attitudes, particularly those of African-Americans, toward this issue have been understudied. Methods: In 2008–2009, we convened 10 focus groups in Durham, N.C. to explore attitudes about returning research results and how different policies might influence their likelihood to participate in genetic/genomic studies. Transcripts were complimented by a short anonymous survey. Of 100 participants, 73% were female and 76% African-American with a median age of 40–49 years. Results: Although there was general interest in obtaining genetics research results, particularly individual results, discussants recognized many potential complexities. The option to obtain research results (individual or summary) was clearly valued and lack thereof was potentially a deterrent for genetic/genomic research enrollment. Conclusions: Providing the option to learn research results may help strengthen relationships between investigators and participants and thereby serve as a positive influencing factor for minority communities. Consideration of the broader implications of returning research results is warranted. Engaging diverse publics is essential to gain a balance between the interests and burdens of participants and investigators.
Response to Antiretroviral Therapy in HIV-Infected Ugandan Children Exposed and Not Exposed to Single-Dose Nevirapine at Birth

Objective:To compare the response to a nevirapine (NVP)-based highly active antiretroviral therapy (HAART) in HIV-infected Ugandan children, exposed and nonexposed to single-dose NVP (sd NVP) at birth. Methods:HIV-infected study children were initiated on stavudine/lamivudine/NVP as a fixed dose combination. CD4 cell percent and HIV-1 RNA were documented at baseline, 12, 24, 36, and 48 weeks post-initiation of HAART. Results:Ninety-two children were enrolled in the study, 44 in the sd NVP-exposed and 48 in the nonexposed cohort. The median age at enrollment was 1.7 years [interquartile range (IQR) 1.2-2.4] and 7.8 years (IQR 5.9-9.2) in the sd NVP-exposed and nonexposed cohorts, respectively (P < 0.001). At baseline and week 48 post-HAART, the median CD4 cell percentages were 14% and 33% for the NVP-exposed group and 8% and 22.5% in the nonexposed group (P < 0.0001). The median (IQR) viral load at baseline was 650,568 (359,979-2,086,613) RNA copies/mL and 239,027 (105,904-494,813) RNA copies/mL in the NVP-exposed and nonexposed cohorts, respectively. After 48 weeks of HAART, 76% of the NVP-exposed and 80% of the nonexposed children had a median viral load of <400 copies/mL (P = 0.74). Conclusions:Both HIV-infected Ugandan older infants and children that were exposed and not exposed to sd NVP at birth had favorable treatment outcomes on NVP-containing HAART.
Determinants of mobile phone output power in a multinational study: implications for exposure assessment

Objectives: The output power of a mobile phone is directly related to its radiofrequency (RF) electromagnetic field strength, and may theoretically vary substantially in different networks and phone use circumstances due to power control technologies. To improve indices of RF exposure for epidemiological studies, we assessed determinants of mobile phone output power in a multinational study. Methods: More than 500 volunteers in 12 countries used Global System for Mobile communications software-modified phones (GSM SMPs) for approximately 1 month each. The SMPs recorded date, time, and duration of each call, and the frequency band and output power at fixed sampling intervals throughout each call. Questionnaires provided information on the typical circumstances of an individual’s phone use. Linear regression models were used to analyse the influence of possible explanatory variables on the average output power and the percentage call time at maximum power for each call. Results: Measurements of over 60 000 phone calls showed that the average output power was approximately 50% of the maximum, and that output power varied by a factor of up to 2 to 3 between study centres and network operators. Maximum power was used during a considerable proportion of call time (39% on average). Output power decreased with increasing call duration, but showed little variation in relation to reported frequency of use while in a moving vehicle or inside buildings. Higher output powers for rural compared with urban use of the SMP were observed principally in Sweden where the study covered very sparsely populated areas. Conclusions: Average power levels are substantially higher than the minimum levels theoretically achievable in GSM networks. Exposure indices could be improved by accounting for average power levels of different telecommunications systems. There appears to be little value in gathering information on circumstances of phone use other than use in very sparsely populated regions.
Effect of Energetic Electron Precipitation on the Northern Polar Vortex: Explaining the QBO Modulation via Control of Meridional Circulation

Energetic electron precipitation (EEP) affects the high‐latitude middle atmosphere by producing NOX compounds that destroy ozone. Earlier studies have shown that in the wintertime polar stratosphere, increased EEP enhances the westerly wind surrounding the pole, the polar vortex. This EEP effect has been found to depend on the quasi‐biennial oscillation (QBO) of equatorial winds, but the mechanism behind this modulation has so far remained unresolved. In this study we examine the atmospheric effect of EEP and its modulation by QBO using the corrected electron flux measurements by NOAA/POES satellites and the ERA‐Interim reanalysis data of zonal wind, temperature, and ozone in winter months of 1980–2016. We verify the EEP‐related strengthening of the polar vortex, warming (cooling) in the upper (lower) stratosphere and a reduction of ozone mass mixing ratio in the polar stratosphere. We also verify that the EEP effect is stronger and more significant especially in late winter, when the QBO at 30 hPa is easterly. We find here that the difference in the EEP effect between the two QBO phases is largest using a roughly 6‐month lag for QBO. We demonstrate that ozone mass mixing ratio in the lower polar stratosphere, a proxy for the strength of Brewer‐Dobson circulation, is also larger during QBO‐E than QBO‐W, with the difference maximizing when the QBO is lagged by 6 months. Our findings indicate that the modulation of the Brewer‐Dobson circulation by QBO controls how the EEP affects the polar vortex.
Networks to Nowhere: Segregation and Stratification in Networks of Information about Schools

Theory: Public sector reforms expanding citizen choice are hypothesized to create many of the benefits of private markets, in part by increasing the incentives of citizens to search for information about the quality of public services. Social scientists have shown that networks can provide valuable shortcuts to the information necessary to participate in this expanded market for public goods. Critics of public sector markets argue, however, that choice will heighten existing inequalities, increasing stratification by education and income and racial segregation. This criticism is particularly evident in debates about school choice. Hypothesis: The quality of networks in school districts with choice is hypothesized to be higher than in school districts without choice and to increase with parental education levels. Networks are also hypothesized to be segregated by race. In addition, differences in networks as a function of education and the segregation of networks by race may be greater in choice districts than in districts with no or little choice. Methods: Two stage generalized least square techniques are used to predict the quality of discussants and racial patterns in education networks while controlling for the problem of nonrandom assignment inherent in different levels of parental involvement in school choice. Results: Higher socioeconomic status individuals are more likely to have higher quality education networks. Education networks also exhibit a high degree of racial segregation. Institutional incentives do not markedly affect the nature of information networks about education-but where effects are found, they tend to indicate higher levels of class stratification and racial segregation.
Immunosuppression and Rejection of Cartilage Formed by Allogeneic Chondrocytes in Rats

Rat syngeneic and allogeneic chondrocytes were transplanted intramuscularly or into defects prepared in articular cartilage (intracartilaginous transplants). Recipients of allogeneic transplants received cyclosporin A (CsA), cladribine (2-chlorodeoxyadenosine, 2-CdA), or both drugs in combination. Transplants were taken for examination after 5 weeks. Cartilage formed intramuscularly by syngeneic chondrocytes was ossified. Allogeneic cartilage was resorbed by infiltrating cells. CsA or 2-CdA partially suppressed, and both these agents in combination strongly suppressed, formation of infiltrations. Both syngeneic and allogeneic chondrocytes formed cartilage in joint surface defects but only allogeneic cartilage was attacked by infiltrating cells. CsA + 2-CdA treatment slightly decreased intensity of infiltrations but did not prevent cartilage resorption. Antichondrocyte response was studied by evaluation of spleen mononuclear cells (SMC) stimulation in mixed splenocyte–chondrocyte cultures and by detection of antichondrocyte cytotoxic antibodies. SMC stimulation index (SI) was calculated separately for syngeneic and allogeneic chondrocytes. Comparison of SMC SI for syngeneic and allogeneic chondrocytes indicated lack of stimulation of SMC from control or syngeneic transplant recipients and significant stimulation of SMC from recipients of allogeneic transplants. SMC from animals treated with CsA + 2-CdA were not stimulated. Additional experiments aiming at an explanation of the lack of stimulation of SMC from intact animals by syngeneic chondrocytes reported in this work and contrary to other findings disclosed that it was caused by the use of collagenase solution containing Nα-p-tosyl-l-lysine chloromethyl ketone for chondrocyte isolation. Spontaneous antichondrocyte cytotoxic antibody activity was found in intact rats raised only in sera from recipients of allogeneic intramuscular transplants without immunosuppression. Thus, strong immunosuppressive treatment of rats with allogeneic chondrocyte transplants was more effective in relation to the general immunological response than to the local reaction.
A"Delphi Exercise"As a Tool in Amazon Rainforest Valuation

The Amazon rainforest, the world's largest and most biodiverse, represents a global public good of which 15 percent has already been lost. The worldwide value of preserving the remaining forest is today unknown. A"Delphi"exercise was conducted involving more than 200 environmental valuation experts from 36 countries, who were asked to predict the outcome of a survey to elicit willingness to pay for Amazon forest preservation among their own countries'populations. Expert judgments of average willingness-to-pay levels, per household per year, to fund a plan to protect all of the current Amazon rainforest up to 2050, range from $4 to $36 in 12 Asian countries, to near $100 in Canada, Germany, and Norway, with other high-income countries in between. Somewhat lower willingness-to-pay values were found for a less strict plan that allows a 12 percent further rainforest area reduction. The elasticity of experts'willingness-to-pay assessments with respect to own-country per capita income is slightly below but not significantly different from unity when results are pooled across countries and income is adjusted for purchasing power parity.
Assessment of markers of bone formation under controlled environmental factors and their correlation with serum minerals in adult sheep as a model for orthopaedic research

Summary Eighteen healthy skeletally mature (3 years old) ewes, with an average weight of 45 kg, of the Portuguese Churra da Terra Quente breed were used to evaluate the normal values of total and bone-specific isoform of alkaline phosphatase serum activities (ALP and BALP, respectively) and serum osteocalcin (OC) and their correlation with the serum minerals - calcium (Ca), phosphorus (P), magnesium (Mg) and ionized calcium (Ca2+). The sheep were maintained under controlled environmental conditions (constant diurnal photoperiod cycle and identical husbandry and feeding) for six weeks before the collection of the blood samples. The measurement of the total ALP and serum minerals was performed with automated biochemistry analysers using the BioMérieux® kits, the serum electrolyte Ca2+ Diametrics Medical, Inc® specific cassettes and the BALP and OC METRATM kits from QUIDEL® Corporation. The mean ± standard deviation values obtained were: total ALP 90.17 ± 85.72 U/L, BALP 15.0 ± 5.44 U/L, ratio BALP/ total ALP 29.28 ± 24.22, OC 13.02 ± 1.87 ng/mL, Ca 2.57 ± 0.37 mmol/L, P 2.13 ± 0.42 mmol/L, Mg 1.04 ± 0.13 mmol/L, Ca2+ 1.29 ± 0.04 mmol/L. Significant correlations were observed between the total ALP and Ca (r = 0.5939; P = 0.05) and OC and Ca (r = 0.5706; P = 0.05). Reference to the serum values of bone turnover parameters in sheep could be of great value in research and could provide complementary non-invasive information on the bone healing process, particularly with regard to obtaining an early prognosis of fracture healing.
Cyst Fluid Cytology and Chemical Features in a Case of Lymphoepithelial Cyst of the Pancreas: A Rare and Difficult Preoperative Diagnosis

Most pancreatic cysts (90%) are inflammatory pseudocysts. Approximately 10% of pancreatic cysts are neoplasms, including serous cystadenomas, and mucinous tumors, some of which are malignant. Analysis of pancreatic cyst fluid obtained by percutaneous or endoscopic fine‐needle aspiration is increasingly being used for the preoperative diagnosis of pancreatic or peripancreatic cysts. However, cyst fluid chemical and cytologic features in less common types of pancreatic cysts have not been reported. Lymphoepithelial cyst of the pancreas is exceedingly rare, and only occasional individual reports have described cyst fluid findings. We report on a case of lymphoepithelial cyst of the pancreas developing in a middle‐aged man. Cyst fluid aspirated under radiological guidance showed elevated levels of carcinoembryonic antigen (CEA), CA19‐9, CA 125, and amylase, and a viscosity greater than that of serum. A cell block preparation of a fine‐needle aspiration showed tissue fragments with a keratinized squamous lining and a lymphocytic infiltrate in the wall, and abundant background keratinous debris. The cytologic and biochemical findings in this case exhibit similarities to the findings reported in other reports, and may represent a recognizable pattern on cyst fluid analysis. Diagn. Cytopathol. 1999;21:328–330. © 1999 Wiley‐Liss, Inc.
First-principles calculation of the thermal properties of silver

The thermal properties of silver are calculated within the quasiharmonic approximation, by using phonon dispersions from density-functional perturbation theory, and the pseudopotential plane-wave method. The resulting free energy provides predictions for the temperature dependence of various quantities such as the equilibrium lattice parameter, the bulk modulus, and the heat capacity. Our results for the thermal properties are in good agreement with available experimental data in a wide range of temperatures. As a by-product, we calculate phonon frequency and Gr\"uneisen parameter dispersion curves which are also in good agreement with experiment.
Theoretic Analysis and Extremely Easy Algorithms for Domain Adaptive Feature Learning

Domain adaptation problems arise in a variety of applications, where a training dataset from the \textit{source} domain and a test dataset from the \textit{target} domain typically follow different distributions. The primary difficulty in designing effective learning models to solve such problems lies in how to bridge the gap between the source and target distributions. In this paper, we provide comprehensive analysis of feature learning algorithms used in conjunction with linear classifiers for domain adaptation. Our analysis shows that in order to achieve good adaptation performance, the second moments of the source domain distribution and target domain distribution should be similar. Based on our new analysis, a novel extremely easy feature learning algorithm for domain adaptation is proposed. Furthermore, our algorithm is extended by leveraging multiple layers, leading to a deep linear model. We evaluate the effectiveness of the proposed algorithms in terms of domain adaptation tasks on the Amazon review dataset and the spam dataset from the ECML/PKDD 2006 discovery challenge.
Long‐term benefits of darifenacin treatment for patient quality of life: Results from a 2‐year extension study

Overactive bladder (OAB), a chronic condition requiring long‐term management, is associated with substantial impact on health‐related quality of life (HRQoL). The short‐term benefits of antimuscarinic drug treatment are well known. Here we investigate the impact on HRQoL of long‐term treatment with the M3‐selective muscarinic receptor antagonist darifenacin over 2 years.
Estimating EQ-5D utility values for major health behavioural risk factors in England

Background Major behavioural risk factors, namely obesity, alcohol consumption, smoking, lack of fruit and vegetable intake and physical inactivity negatively impact on self-reported quality of life. However, little is known about their impact on preference-based measures of health-related quality of life commonly used to inform economic evaluations. Methods Preference-based health-related quality of life outcomes associated with major behavioural risk factors were estimated using the EuroQol EQ-5D responses of 14 117 participants, aged ≥16 years, in the 2008 Health Survey for England. Multivariable linear regression was used to model the relationship between the five risk factors and EQ-5D utility scores. In addition, logistic regression was used to model their relationship to dichotomous reports of problems for each of the five EQ-5D dimensions. Results Only one-third of participants had a body mass index within normal range, never drank alcohol, consumed at least five portions of fruit or vegetable/day or exercised regularly, while nearly half of participants were smokers or ex-smokers. In the fully adjusted multivariable analyses, reductions in EQ-5D utility scores (95% CI) of 0.105 (0.072 to 0.137), 0.062 (0.042 to 0.082) and 0.142 (0.129 to 0.155) were estimated for a body mass index ≥40 kg/m2, heavy smoking (≥20 cigarettes/day) and physical inactivity, respectively. Hazardous alcohol consumption (men >4 and ≤8 units/day; women >3 and ≤6 units/day) and daily fruit and vegetable intake between three and less than five portions were associated with small positive effects on EQ-5D utility scores (p<0.05). Conclusions The high prevalence and substantial utility loss associated with obesity, smoking and physical inactivity highlight the potential impact that interventions aimed at their prevention or alleviation may have on population health.