Miracle-dz/UniFAR-FTUs huggingface dataset:
Cross-Cultural Generalizability of the Reactive–Proactive Aggression Questionnaire (RPQ)

In this study, we assessed the cross-cultural generalizability of the Reactive–Proactive Aggression Questionnaire (RPQ) and tested the hypotheses that boys show higher levels of proactive aggression with increasing age and that a two-factor (reactive–proactive) structure will be observed in an East Asian population. We administered the RPQ to 5,615 male and female 11- to 15-year-old schoolchildren. CFA demonstrated a good fit of the two-factor reactive–proactive model. Proactive aggression increased significantly with age in boys but not girls, whereas reactive aggression showed no gender difference and only a minimal age increase. Results suggest the presence of meaningful differences between these aggression subtypes and the generalizability of the RPQ in an East Asian population.
Cutaneous and Oral Lesions in 32 Children After Renal Transplantation

Abstract: A variety of skin and oral mucosal lesions appearing in patients after renal transplantation have been reported in the literature. Because most of these data pertain to adults, we studied a group of children with kidney transplants to investigate the occurrence of skin and/or oral mucosal lesions, compare them with those observed in adults, and contribute to the knowledge of the pathogenesis of these disorders.
A Regime-Switching Model of Cyclical Category Buying

In many categories consumers display cyclical buying: they repeatedly purchase in the category for several periods, followed by several periods of not buying. We believe that the cyclicality is a manifestation of cross-category substitution by the consumer, caused by “variety-seeking” tendencies as well as by the firm's marketing activities in all relevant categories. We propose a Markov regime-switching random coefficient logit model to represent these behaviors as stochastic switching between high and low category purchase tendencies. The main feature of the proposed model is that it divides the stream of purchase decisions of a consumer into distinct regimes with different parameter values that characterize high versus low purchase tendencies. In an empirical application of the model to purchases of yogurt-buying households, we find that as many as 38.3% households display cyclicality between high and low yogurt-purchasing tendencies. Predictions from our proposed model track observed yogurt purchases of households over time closely, and the model also fits better than two benchmark models. Alternating between high and low purchase tendencies may correspond with changing levels of consumer inventory in a substitute category. If one ignores this phenomenon, a correlation between yogurt inventory and the error term in utility arises, leading to biased estimates. Also, we show that cyclicality in buying has a key implication for a firm's price promotion strategies: a price reduction that is offered to a household during its high purchasing tendency period will result in greater increases in sales than one that is offered during its low purchasing period. This opens up a new dimension for enhancing the effectiveness of promotions---customized timing of price reductions.
Alternative Medicine Use by Individuals with Major Depression

Objective: To describe the use of alternative medicine (AM) by persons with major depression and to examine the factors associated with AM use among these individuals. Methods: We used data from the 1994–1995 and 1996–1997 National Population Health Surveys. We selected subjects who had major depression according to the Composite International Diagnostic Interview Short Form for Major Depression (CIDI-SFMD). The prevalence of AM and conventional health service use by the subjects was calculated for each survey and was stratified by province. We employed logistic regression to examine the factors associated with AM use. Results: There was a temporal trend toward increasing use of AM among persons with major depression. The prevalence of AM use among subjects with major depression was 7.8% in 1994–1995 and 12.9% in 1996–1997. Female sex, having more than 12 years' education, and having 1 or more long-term medical conditions were associated with an increased likelihood of using AM. The sex difference in AM use depended on subjects' age in 1996–1997. Conclusion: General practitioners, mental health specialists, and AM providers should be aware of their patients' use of both conventional medical services and AM because there may be interactions between conventional and alternative treatments. Communication and, if possible, cooperation may lead to improved outcomes in the management of depressive disorders.
MicroRNA-214 Suppresses Gluconeogenesis by Targeting Activating Transcriptional Factor 4*

Background: miR-214 targets ATF4 involved in glucose metabolism; however, the role of miR-214 and ATF4 in hepatic gluconeogenesis is unknown. Results: Overexpression of miR-214 suppresses gluconeogenesis in hepatocytes in vitro and in vivo via the ATF4-dependent pathway. Conclusion: miR-214 suppresses gluconeogenesis via targeting ATF4. Significance: Our studies reveal that the miR-214-ATF4 axis is a novel pathway for the regulation of hepatic gluconeogenesis. Although the gluconeogenesis pathway is already a target for the treatment of type 2 diabetes, the potential role of microRNAs (miRNAs) in gluconeogenesis remains unclear. Here, we investigated the physiological functions of miR-214 in gluconeogenesis. The expression of miR-214 was suppressed by glucagon via protein kinase A signaling in primary hepatocytes, and miR-214 was down-regulated in the livers of fasted, high fat diet-induced diabetic and leptin receptor-mutated (db/db) mice. The overexpression of miR-214 in primary hepatocytes suppressed glucose production, and silencing miR-214 reversed this effect. Gluconeogenesis was suppressed in the livers of mice injected with an adenovirus expressing miR-214 (Ad-miR-214). Additionally, Ad-miR-214 alleviated high fat diet-induced elevation of gluconeogenesis and hyperglycemia. Furthermore, we found that activating transcription factor 4 (ATF4), a reported target of miR-214, can reverse the suppressive effect of miR-214 on gluconeogenesis in primary hepatocytes, and this suppressive effect was blocked in liver-specific ATF4 knock-out mice. ATF4 regulated gluconeogenesis via affecting forkhead box protein O1 (FOXO1) transcriptional activity. Finally, liver-specific miR-214 transgenic mice exhibited suppressed gluconeogenesis and reduced expression of ATF4, phosphoenolpyruvate carboxykinase, and glucose-6-phosphatase in liver. Taken together, our results suggest that the miR-214-ATF4 axis is a novel pathway for the regulation of hepatic gluconeogenesis.
Brief Cognitive Behavioural Therapy with Male Adolescent Offenders in Open Custody or on Probation: An Evaluation of Management of Anger

A 6-wk. cognitive behavioural program administered to 24 adolescent male offenders assigned to open custody and 5 to probation showed no mean differences on the Test of Nonverbal Intelligence, the Minnesota Multiphasic Personality Inventory, and the Coopersmith Self-esteem Inventory. Significant correlations were found for the personality measures with pretreatment and posttreatment scores on the Buss-Durkee Hostility Inventory.
Predicting Three-Year Kidney Graft Survival in Recipients with Systemic Lupus Erythematosus

Predicting the outcome of kidney transplantation is important in optimizing transplantation parameters and modifying factors related to the recipient, donor, and transplant procedure. As patients with end-stage renal disease (ESRD) secondary to lupus nephropathy are generally younger than the typical ESRD patients and also seem to have inferior transplant outcome, developing an outcome prediction model in this patient category has high clinical relevance. The goal of this study was to compare methods of building prediction models of kidney transplant outcome that potentially can be useful for clinical decision support. We applied three well-known data mining methods (classification trees, logistic regression, and artificial neural networks) to the data describing recipients with systemic lupus erythematosus (SLE) in the US Renal Data System (USRDS) database. The 95% confidence interval (CI) of the area under the receiver-operator characteristic curves (AUC) was used to measure the discrimination ability of the prediction models. Two groups of predictors were selected to build the prediction models. Using input variables based on Weka (a open source machine learning software) supplemented with additional variables of known clinical relevance (38 total predictors), the logistic regression performed the best overall (AUC: 0.74, 95% CI: 0.72–0.77)–significantly better (p < 0.05) than the classification trees (AUC: 0.70, 95% CI: 0.67–0.72) but not significantly better (p = 0.218) than the artificial neural networks (AUC: 0.71, 95% CI: 0.69–0.73). The performance of the artificial neural networks was not significantly better than that of the classification trees (p = 0.693). Using the more parsimonious subset of variables (six variables), the logistic regression (AUC: 0.73, 95% CI: 0.71–0.75) did not perform significantly better than either the classification tree (AUC: 0.70, 95% CI: 0.68–0.73) or the artificial neural network (AUC: 0.73, 95% CI: 0.70–0.75) models. We generated several models predicting 3-year allograft survival in kidney transplant recipients with SLE that potentially can be used in practice. The performance of logistic regression and classification tree was not inferior to more complex artificial neural network. Prediction models may be used in clinical practice to identify patients at risk.
Blockade of NKG2D Synergized With CTLA4-Ig in Promoting Long-Term Graft Survival in Murine Models of Cardiac Transplantation [RETRACTED]

BACKGROUND Blockade of B7-CD28 interaction with CTLA4-Ig could prolong allograft survival in cardiac transplantation. NKG2D is an activating or coactivating receptor on NK cells, γδ T, and CD8 T cells and played an important role in transplant immunity. METHODS C57BL/6 (wild type and γδ or interleukin (IL)-17) mice were transplanted with allogeneic BALB/c hearts and treated with CTLA4-Ig alone or in combination with anti-NKG2D monoclonal antibodies. The survival of grafts was monitored daily by abdominal palpation until the complete cessation of cardiac contractility. RESULTS We found that wild type recipient treated with anti-NKG2D monoclonal antibodies plus CTLA4-Ig showed significantly prolonged survival cardiac allograft (>90 days, P<0.001). These in vivo results in combined therapy group correlated with low expression of interferon-γ whereas increased expression of IL-4 and alternatively activated macrophage markers. Furthermore, with blockade of NKG2D, the number of IL-17-producing γδ T cells was significantly reduced, which was demonstrated as the main source of IL-17 production. And in our γδ and IL-17 murine cardiac transplantation models, we found that γδ or IL-17 deficiency could significantly prolong cardiac allograft survival. CONCLUSION Blockade of NKG2D is effective in synergizing with CTLA4-Ig to promote long-term cardiac allograft survival in mice, and this effect is associated with decreased infiltration of IL-17-producing γδ T cells.
Application of digital image processing to detect transformer bushing faults and oil degradation using FRA polar plot signature

Frequency Response Analysis (FRA) technique is commonly used to assess the mechanical integrity of power transformer core and windings. A few papers investigating the ability of FRA technique to detect bushing faults and transformer oil degradation can be found in the literatures. However, in all of these papers, only magnitude of the FRA signature along with visual analysis was used for fault identification and quantification which may lead to inconsistent conclusions for the same FRA signature when interpreted by various personnel. As such, there is an essential need to standardize and automate the FRA interpretation process to improve its reliability and accuracy. This paper is taking a step forward toward this goal through presenting a new FRA interpretation approach by incorporating the magnitude and phase angle plots of the measured FRA signature into one polar plot that comprises more features than the conventional magnitude plot currently used for fault diagnosis. Moreover, the proposed polar plot facilitates the application of digital image processing techniques (DIP) to automate and standardize the whole process. The new proposed technique is assessed through its application to detect minor transformer bushing faults and insulating oil degradations. In this regard, two transformers of different ratings, winding structure and physical dimensions are simulated using 3D finite element analysis to implement various levels of transformer bushing faults and oil degradation. The obtained FRA polar plots of the two investigated transformers under various bushings and oil health conditions are manipulated using the developed DIP codes to investigate the impact of each fault type / level on the proposed polar plot signature. Also, Practical measurements are performed to validate simulation results and evaluate the feasibility of the proposed technique. Results show the ability of the proposed technique to automate the detection of minor levels of bushing faults and insulating oil degradation with a high degree of accuracy.
CONSTANT ERRORS IN WEIGHT JUDGEMENTS AS A FUNCTION OF THE SIZE OF THE DIFFERENTIAL THRESHOLD.

Constant errors in psychophysical procedures are known to increase in magnitude with the intensity of the standard, and with the temporal or spatial separation of the standard and comparison stimuli. It is often assumed that this is due to increasing ‘adaptation’ of the effective standard. It is argued here that the increase is due to a statistical artifact, since the measures of constant error and of differential threshold normally used are not independent, so that any factor which increases the difficulty of discrimination will increase the magnitude of the constant error. It is shown that for differential thresholds ranging from 1 to 25 g. the absolute size of the constant error increases with the size of the threshold, but the direction of the error is variable and remains unexplained.
Opening Up Closure: Semiotics Across Scales

Abstract: The dynamic emergence of new levels of organization in complex systems is related to the semiotic reorganization of discrete/continuous variety at the level below as continuous/discrete meaning for the level above. In this view both the semiotic and the dynamic closure of system levels is reopened to allow the development and evolution of greater complexity.
Phyllosilicate and hydrated silica detections in the knobby terrains of Acidalia Planitia, northern plains, Mars

Here we report detections of Fe/Mg phyllosilicates and hydrated silica in discrete stratigraphic units within the knobby terrains of Acidalia Planitia made using data acquired by Compact Reconnaissance Imaging Spectrometer for Mars. Fe/Mg phyllosilicates are detected in knobs that were eroded during southward retreat of the dichotomy boundary. A second later unit, now eroded to steep‐sided platforms embaying the knobs, contains hydrated silica, which may have formed via localized vapor weathering, thin‐film leaching, or transient water that resulted in surface alteration. These are then overlain by smooth plains with small cones, hypothesized to be mud volcanoes which previous studies have shown to have no hydrated minerals. In spite of Acidalia's location within the putative northern ocean, collectively, the data record a history of aqueous processes much like that in the southern highlands with progressively less intensive aqueous chemical alteration from the Noachian to Amazonian.
Shear bond strength between composite resin and denture teeth: effect of tooth type and surface treatments.

PURPOSE The purpose of this study was to investigate the strength of the composite resin-denture tooth bond as affected by different tooth surface treatments. MATERIALS AND METHODS Spectrum TPH was condensed on 112 mandibular first molar acrylic resin and composite resin denture teeth, which received seven different treatments: Four groups were treated with Prime & Bond NT adhesive, and three groups were treated with One Step adhesive. Four groups (two of each adhesive category) were treated with Composite Activator and air abrasion. In one group, AeliteFlo was used just before the condensation of Spectrum TPH. Bond strength was evaluated with a shear test device on a Monsanto testing machine. The results were evaluated statistically with two-way ANOVA and the Scheffé method. RESULTS There was a significant interaction between denture tooth type and surface treatments. Bond strength of composite resin was greater to composite than to acrylic resin teeth when the bond was mediated only with adhesives. One Step adhesive and AeliteFlo resulted in a higher bond of composite resin to both types of teeth. Wetting tooth surfaces with Composite Activator did not increase the bond. CONCLUSION When repairing denture teeth with composite resin and adhesives, the bond strength was higher with composite than with acrylic resin teeth, and there were differences between the adhesives used.
Comparison of the effects of surface roughness and confinement on rotor–stator cavity flow

ABSTRACT Results of a computational study are discussed which investigate roughness-induced and geometry-induced (confinement) effects on the steady-state velocity components in 3-D boundary-layer flow over the rotor disc in a rotor–stator flow configuration. It is found that, for the rotor–stator flow investigated, the roughness-induced effects are very similar to geometry-induced effects, both in nature and magnitude. The overall aim was to compare these two types of effects with corresponding roughness-induced effects in the von Kármán boundary-layer flow over a disc spinning freely in an unrestricted fluid environment. The research was conducted in the context of a programme investigating surface roughness as a means of laminar flow control for the development of new passive drag-reduction techniques. The goal was to establish whether it was possible unequivocally to distinguish between roughness-induced and geometry-induced effects on the boundary-layer flow above the rotor disc. The results obtained suggest that, for the type of system discussed here, it must be expected to be difficult to distinguish between these effects in experiments. The similarities regarding the nature and magnitude of results obtained from comparing predictions for three different computational modelling approaches indicate the required sensitivity of measurement technologies aiming to resolve the investigated effects in experimental studies.
The impact of post-event information on study-related memories: An exploration of the roles of judgemental anchoring, specific expectations about change, and motivational influences

We explored how well common theories about the impact of post-event information on memories explain recollections that occur naturally in university students’ study routines. Instead of starting from a familiar research paradigm, such as those used in hindsight-bias research, the present study used a situation common to university students, and examined how well three candidate explanations—judgemental anchoring, implicit theories of change, and motivational influences—could explain the results we obtained in a long-term memory study that included three sessions, six months apart. We found that about two thirds of the memories of study-related issues were indeed biased, and that the impact of post-event information being used as an anchor is the most plausible explanation for the results. There were also some indications that memory biases might have been due, at least in part, to motivational factors.
Amplified-Fragment Length Polymorphism Analysis versus Macro-Restriction Fragment Analysis for Molecular Typing ofStreptococcus pneumoniae Isolates

ABSTRACT Forty-eight pneumococci were genotyped by on-line laser fluorescence amplified-fragment length polymorphism (AFLP) and pulsed-field gel electrophoresis (PFGE) analysis of chromosomal restriction fragments. Overall, the data generated by the two methods corresponded well. However, with AFLP, clusters were delineated at a higher similarity level, and isolate differentiation was more pronounced. AFLP and PFGE were equally efficient for assessing intraserotype diversity. We conclude that AFLP is a useful alternative to PFGE.
PATHOGENICITY STUDIES ON TRICHOMONAS GALLINARUM IN DOMESTIC POULTRY.

Abstract A STUDY of the pathogenicity of Trichomonas gallinarum was initiated following reports of low egg production due to trichomoniasis in laying flocks in the Southeastern United States. Several diagnosticians had reported trichomonads of the lower digestive tract as the primary pathogenic agents detected in these flocks. They have generally followed the standard textbooks on poultry disease (Barger et al., 1958; and Biester and Schwarte, 1959) in ascribing pathogenicity to these organisms. Becker, who reviews this subject in the latter text, is the author most frequently quoted. In this section Allen’s publications (1936, 1940, 1941) and Olsen and Allen (1942) together with other quotations give the impression that the organism is a pathogen. Allen described (1941) elevated, cheesy, cream-colored hepatic lesions which she claimed could be differentiated from the depressed lesions caused by Histomonas meleagridis. In reviewing Allen’s work Stabler (1947) indicated that confirmatory experiments were required. Among others who have…
Photochemical treatment of platelet concentrates with amotosalen hydrochloride and ultraviolet A light inactivates free and latent cytomegalovirus in a murine transfusion model

BACKGROUND: A photochemical treatment (PCT) process utilizing amotosalen hydrochloride and long wavelength UVA light has been developed to inactivate pathogens in PLTs. This study investigated the effects of amotosalen/UVA treatment on free and latent murine CMV (MCMV) in PLT preparations using a murine model of transfusion‐transmitted CMV (TT‐CMV).
Symptom factors in early-onset psychotic disorders.

OBJECTIVE To examine the factor structure of symptom ratings in early-onset psychotic illnesses. METHOD Subjects were drawn from a 2-year prospective study of early onset psychotic disorders. Principal components analysis with orthogonal (varimax) rotation was used to create factors from baseline ratings on the Schedule for Positive Symptoms, the Schedule for Negative Symptoms, and the Brief Psychiatric Rating Scale for Children. RESULTS Youths with schizophrenia (n = 27), bipolar disorder (n = 22), and psychosis not otherwise specified (n = 20) were included. Four symptom factors were identified: negative symptoms, positive symptoms, behavioral problems, and dysphoria. Negative symptoms were predictive of the diagnosis of schizophrenia and treatment with antipsychotic medications. Neither behavior problems nor dysphoria were predictive of diagnosis. In subjects who completed follow-up assessments at year 1 (n = 49) and year 2 (n = 39), negative symptoms and behavioral problems predicted poorer functioning. CONCLUSIONS The four factors are clinically relevant, with both treatment planning and prognostic implications. Negative symptoms best differentiated schizophrenia from the other disorders. Behavior problems and dysphoria were nonspecific problems that occurred in all three disorders, which likely leads to misdiagnosis in community settings.