Miracle-dz/UniFAR-FTUs huggingface dataset:
A systematic review of occupational safety and health business cases.

OBJECTIVE Business cases are commonly developed as means to rationalize investment. We systematically reviewed 26 reported cases on occupational safety and health (OSH) interventions to assess if health and productivity arguments make a good business case. METHODS To be included in the review, studies had to analyze the costs and benefits, including productivity, of an OSH intervention at the enterprise level. We searched Medline and Embase for studies and used Google search in addition. Two reviewers independently selected studies and extracted data. The intervention profitability was calculated in euros (euro in 2008) as the first year's benefits minus the total intervention costs per worker. The payback period was calculated as the intervention costs divided by the first year's benefits. RESULTS We found three ex-ante and 23 ex-post cases. In 20 cases, the study design was a before-after comparison without a control group. Generally a 100% reduction of injuries or sickness absence was assumed. In two cases, productivity and quality increases were very large. The main benefit was avoided sick leave. Depreciation or discounting was applied only in a minority of cases. The intervention profitability was negative in seven studies, up to euro 500 per employee in 12 studies and more than euro 500 per employee in seven studies. The payback period was less than half a year for 19 studies. Only a few studies included sensitivity analyses. CONCLUSIONS Few ex-ante business cases for management decisions on OSH are reported. Guidelines for reporting and evaluation are needed. Business cases need more sound assumptions on the effectiveness of interventions and should incorporate greater uncertainty into their design. Ex-post evaluation should be based preferably on study designs that control for trends at a time different from that of the intervention.
In vitro treatment of monocytes with 8‐methoxypsolaren and ultraviolet A light induces dendritic cells with a tolerogenic phenotype

Extracorporeal photopheresis (ECP) has been considered an efficient dendritic cell (DC) therapy, used for treating both T cell malignancy, as well as T cell‐mediated diseases. During the ECP procedure leucocytes are exposed to photoactivable agent 8‐methoxypsolaren (8‐MOP) and ultraviolet (UV) A radiation (PUVA) prior to reinfusion. Despite its clinical efficacy the mechanism of action remains elusive. As it has been reported that ECP might promote the differentiation of monocytes into immature DCs, we investigated the effects of UVA light (2 J/cm2) and 8‐MOP (100 ng/ml) on in vitro monocyte‐to‐DC differentiation from normal donors. DCs were generated from human purified CD14+ cells. Because monocytes are killed by PUVA and taking into account that only 5–10% of circulating mononuclear cells are exposed to PUVA during the ECP procedure, we developed an assay in which 10% of PUVA‐treated monocytes were co‐cultured with untreated monocytes. We first demonstrate that the presence of 10% apoptotic cells and monocyte activation were not enough to induce monocyte differentiation into DCs. Adding cytokines to our culture system, we obtained immature DCs characterized by significantly higher phagocytic activity and human leucocyte antigen D‐related (HLA‐DR) expression. These DCs preserved the capacity to be activated by lipopolysaccharide, but showed a reduced capacity to induce allogeneic T cell proliferation when first co‐cultured with 10% of PUVA‐treated cells. Our experimental design provides a novel insight into the real action of 8‐MOP and UVA light on dendritic cell biology, suggesting an additional mechanism by which 8‐MOP and UVA light exposure may influence immune responses.
Subacute Cutaneous Lupus erythematosus Associated with Tamoxifen Therapy: Two Cases

251 tered with low cost and few side-effects but may be insufficient in case of lymphatic involvement [4]. Systemic treatment by intramuscular injection of antimony salts or pentamidine has also been used, but with a high risk of side-effects [4]. More recently, a controlled study reported the treatment of CL caused by L. major by 200 mg/ day of oral fluconazole during 6 weeks [8]. This placebo-controlled trial performed on 209 patients in Saudi Arabia reported a healing rate of 59% in the treated group versus 22% in the placebo group. In our observation, intralesional antimonial compound injections were difficult because of the distal situation of the left lesion, and the lymphatic involvement claimed for a systemic therapy. Fluconazole is excreted in breast milk, but is generally well tolerated compared to pentamidine or systemic antimony salts and has been used in neonates to treat systemic candidiasis without significant side-effects [9]. Fluconazole seemed effective with a clear improvement of the lesions, was well tolerated and allowed the continuation of breast-feeding. We could not exclude a spontaneous regression of those lesions, but they had been present for 16 months and the clearing was concomitant with the fluconazole therapy. Fluconazole is a systemic treatment which appears to be also effective in L. tropica CL, with a better tolerance than other systemic therapies. However, the high cost of this treatment (around 800 euros) makes its use difficult in endemic areas, such as Afghanistan. It could however be an interesting therapeutic option for large or disseminated lesions, or for lesions resistant to topical treatments.
Public Markets, Private Orderings and Corporate Governance

In the New Property Rights approach the degree of incompleteness of markets is taken independently of the cost of the public ordering and of their efficiency relatively to private orderings. In this approach "public markets", similarly to a Swiss cheese, are either assumed to be non-existent empty holes (because of infinite third party verification costs) or assumed to be smooth and efficient (because of zero third party verification costs). When we allow for positive but not infinite third party verification costs we are necessarily pushed back to the insights of Commons, Coase, Fuller and Williamson. The degree of (in) completeness of public markets becomes an endogenous economic problem and managers can be seen as agents that make "second order" specific investments to run specific relations that cannot be efficiently run by public markets. Managers and the public authorities build respectively private and public "legal equilibria" that set the working rules within which transactions can take place. Private and public legal equilibria are not only substitutes but also complements. This complementarity is an important source of the path dependency that characterises the development of different legal systems. The framework is applied to GM's acquisition of Fisher Body. We claim that, contrary to the claims of the New Property Rights approach, the advantages of the acquisition cannot be due to the incentives of private property but should be rather related to the replacement of public markets by the new private ordering set up by Alfred Sloan.
Influence of human papillomavirus on the clinical presentation of oropharyngeal carcinoma in the United States

Much of what is known about the significance of human papillomavirus (HPV) in oropharyngeal squamous cell carcinoma is derived from single‐institution retrospective studies, post hoc analyses of tissue specimens from clinical trials, and tissue bank studies with a small sample size. The objective of this study is to investigate the impact of HPV on the frequency and clinical presentation of oropharyngeal carcinoma in a large, national sample with information from patients who underwent HPV testing.
Dual printed meander monopole antennas for passive UHF RFID tags

This paper presents two new compact designs of dual printed meander monopole antennas for passive UHF RFID tags that operate with multi-port RFID chips. The designed antennas have a smaller footprint in comparison with the commonly used dual dipole-type antennas thus reducing the area needed for the RFID tag. For maximum power transfer to the chips and conjugate impedance matching, the antennas are inductively-coupled with printed loops. A compact tag prototype is fabricated with the area of only 51 mm × 43 mm using a Rogers RO4350B substrate with the thickness of 1.524 mm. Experimental results demonstrate achieving a maximum readable range of 8.65 m.
Fluconazole resistance in Candida species: a current perspective

Candida albicans and the emerging non-albicans Candida spp. have significant clinical relevance among many patient populations. Current treatment guidelines include fluconazole as a primary therapeutic option for the treatment of these infections, but it is only fungistatic against Candida spp. and both inherent and acquired resistance to fluconazole have been reported. Such mechanisms of resistance include increased drug efflux, alteration or increase in the drug target, and development of compensatory pathways for producing the target sterol, ergosterol. While many mechanisms of resistance observed in C. albicans are also found in the non-albicans species, there are also important and unexpected differences between species. Furthermore, mechanisms of fluconazole resistance in emerging Candida spp. , including the global health threat Candida auris, are largely unknown. In order to preserve the utility of one of our fundamental antifungal drugs, fluconazole, it is essential that we fully appreciate the manner by which Candida spp. manifest resistance to it.
Resonance light scattering: a new technique for studying chromophore aggregation

Light scattering experiments are usually performed at wavelengths away from absorption bands, but for species that aggregate, enhancements in light scattering of several orders of magnitude can be observed at wavelengths characteristic of these species. Resonance light scattering is shown to be a sensitive and selective method for studying electronically coupled chromophore arrays. The approach is illustrated with several examples drawn from porphyrin and chlorin chemistry. The physical principles underlying resonance light scattering are discussed, and the advantages and limitations of the technique are reviewed.
Is There Shareholder Expropriation in the United States? An Analysis of Publicly Traded Subsidiaries

Abstract This paper examines the relation between the performance and valuations of publicly traded subsidiaries in the United States and the ownership stake of their parent companies. Cross-sectional and time-series tests demonstrate that subsidiaries of parents that own a substantial minority stake exhibit negative peer-adjusted operating performance and are valued at a 23% median discount relative to peers. In contrast, majority-owned and fully divested subsidiaries show no abnormal performance or valuations. The results of our study indicate that the association between parent ownership and subsidiary performance is nonlinear and that some parents behave opportunistically toward their publicly traded subsidiaries.
Factor Structure of the Disgust Scale–Revised in an Adolescent Sample

Although recent research with the Disgust Scale–Revised (DS-R) has contributed to current knowledge regarding the structure of disgust, this line of research has exclusively employed adult samples. The current study extended existing research by examining the factor structure of the DS-R in an adolescent sample (N = 637). Exploratory factor analysis revealed three factors: Contagion, Mortality, and Contact Disgust. Subsequent to removing three items due to inadequate factor loadings, confirmatory factor analysis provided support for the 3-factor model across gender, grade level, and racial subgroups. Tests of item–intercept invariance also revealed no differences in item means across grade level. However, three and four items were associated with differences across race and gender, respectively. Latent factor means were also found to be invariant across racial groups and grade level, but not across gender. Implications of the DS-R factor structure in this adolescent sample and its domains are discussed.
Plasmacytoma-like post-transplantation lymphoproliferative disease occurring in a cardiac allograft: a case report and review of the literature.

Case Report A 33-year-old woman with a history of an orthotopic heart transplantation in 2006 for a left anterior descending artery dissection presented 5 years post-transplantation with intermittent palpitations and light headedness for 2 months. The patient had multiple episodes of acute and chronic rejection since her transplantation, and her immunosuppression consisted of prednisone 5 mg per day, mycophenolate mofetil, tacrolimus, and rapamune at the time of presentation. Telemetry monitoring revealed a new onset of sinus pauses. An echocardiogram showed normal biventricular function with left ventricular hypertrophy and biatrial enlargement. Myocardial magnetic resonance imaging of the heart demonstrated patchy areas of delayed contrast enhancement that mostly involved the left ventricular inferior and lateral wall (Fig 1A, arrow), foci within the inferior septum (Fig 1B, arrow), and the right ventricular free wall and apex, which indicated a pattern not typical of ischemic disease and most compatible with an infiltrative process. An endomyocardial biopsy revealed sheets of plasma cells (Figs 2A and 2B; hematoxylin and eosin stain; original magnifications: A, 20; B, 100) that were CD138 (Fig 2C; immunohistochemical stain for CD138; original magnification 40) and light chain restricted (Fig 2D; in situ hybridization stain for kappa light chains; original magnification 20), with only occasional lightchain positivity (Fig 2E; in situ hybridization stain for lambda light chains; original magnification 20). Epstein-Barr virus (EBV) –encoded RNA in situ hybridization stain was negative (Fig 2F; original magnification 40). Diffuse lymphocytic infiltrates of the myocardium were found in the background, which were consistent with grade 1R cellular rejection according to the International Society for Heart and Lung Transplantation criteria. This presentation was consistent with plasmacytoma-like monomorphic B-cell posttransplantation lymphoproliferative disease (PTLD) occurring in the setting of graft rejection.
Does the type of tibial component affect mechanical alignment in unicompartmental knee replacement?

PURPOSE There are a number of factors responsible for the longevity of unicompartmental knee replacements (UKR). These include the magnitude of postoperative alignment and the type of material used. The effect of component design and material on postoperative alignment, however, has not been explored. MATERIALS AND METHODS We retrospectively reviewed 89 patients who underwent UKR with robotic guidance. Patients were divided into two groups, according to whether they had received an all-polyethylene inlay component (Inlay group) or a metal-backed onlay component (Onlay group). We explored the magnitude of mechanical alignment correction obtained in both groups. RESULTS Mean postoperative mechanical alignment was significantly closer to neutral in the Onlay group (mean=2.8°; 95% CI=2.4°, 3.2°) compared to the Inlay group (mean=3.9°; 95% CI=3.4°, 4.4°) (R2=0.65; P=0.003), adjusting for gender, BMI, age, side and preoperative mechanical alignment (Fig. 2). Further exploration revealed that the thickness of the tibial polyethyelene insert had a significant effect on postoperative alignment when added to the model (R2=0.68; P=0.01). CONCLUSION Patients who received a metal-backed Onlay tibial component obtained better postoperative mechanical alignment compared to those who received all-polyethylene Inlay prostheses. The thicker overall construct of Onlay prostheses appears to be an important determinant of postoperative alignment. Considering their higher survivorship rates and improved postoperative mechanical alignment, Onlay prostheses should be the first option when performing medial UKR.
Social and economic correlates of depressive symptoms and perceived stress in South African adults

Objectives: Adults in South Africa demonstrate rates of mental illness at or above levels elsewhere in the developing world. Yet there is a research gap regarding the social context surrounding mental health in this region. The objective of this analysis was to characterize the prevalence and correlates of depressive symptoms and perceived stress among a heterogeneous South African population. Methods: Low-income adults (n = 257) in Capetown, Port Elizabeth and Durban were interviewed regarding demographics, income, subjective social status, life events and decision-making. The Center for Epidemiologic Studies Depression Scale (CES-D) and Cohen’s Perceived Stress Scale (PSS) were used. Results: CES-D scores were 18.8 (SD 11.7), with 50.4% of men and 64.5% of women exceeding the cut-off at which professional care is recommended (p = 0.03). PSS scores were 18.6 (SD 6.7), with a mean of 17.5 among men and 19.6 among women (p = 0.02). In multivariate regressions, increased CES-D scores were associated with more household members (p<0.1), lower educational attainment (p = 0.07), less income stability (p<0.07), lower subjective social status (p<0.01) and independent decision-making (p = 0.04). Increased PSS scores were associated with female gender (p<0.05), multiracial race (p<0.02), more household members (p<0.1), lower subjective social status (p<0.02) and recent birth or catastrophe (p<0.01). Conclusions: Depressive symptoms and perceived stress are public health concerns in this sample, with more symptoms among those with fewer resources. The prevention of mental illness is critical, especially in vulnerable populations.
The susceptibility of mother mice and pregnant mice to the virus of foot-and-mouth disease.

Experiments revealed that certain pregnant mice and mother mice nursing young were susceptible to foot-and-mouth disease virus produced in cultures of bovine kidney cells. Removal of the young 1 or 2 days before inoculation resulted in a decrease in the susceptibility of the mother mice. Regardless of the amount of virus inoculated, a maximum of about 40% to 70% of the mothers were susceptible, whereas others displayed no sign of infection.
Enhancing the consumer-perceived benefits of a mass-customized product through its online sales configurator: An empirical examination

Purpose The purpose of this paper is to focus on online sales configurators (SCs), also known as mass-customization toolkits, which enable consumers to self-customize their product solutions online. The paper aims to provide new insights into which characteristics of an online SC increase the consumer-perceived benefits of possessing a mass-customized product. Design/methodology/approach Previous studies on mass customization (MC), sales configuration, and learning psychology are used to develop the research hypotheses, which are tested by analyzing data from 675 configuration experiences from a convenience sample of potential consumers using 31 real online SCs for laptops/notebooks, economy cars, and sport shoes/sneakers. Findings The paper finds support for the hypotheses that SCs with higher flexible-navigation, focused-navigation, and easy-comparison capabilities enhance not only the traditionally considered utilitarian benefit (UT), but also the consumer-perceived uniqueness benefit (UN) and self-expressiveness (SE) benefit (SE). Furthermore, consistent with the study’s hypotheses, SCs with higher benefit-cost communication and user-friendly product-space description capabilities are found to improve UT. The hypotheses that these two capabilities enhance UN and SE, however, are not supported. Post-hoc analyses suggest that the examined SCs are generally UT-centered and need improvement of their ability to communicate the UN and the SE a consumer could derive from the purchase of his/her configured product. Originality/value While prior research has primarily been concerned with conceptually arguing and empirically showing that uniqueness and self-expressiveness are two additional sources of consumer value in business-to-consumer MC, this is the first empirical study that offers insights into which characteristics online SCs should have in order to draw from these two value sources.
Caffeine-induced Ca2+ oscillations in type I horizontal cell of carp retina: A mathematical model

Oscillations in intracellular free Ca2+ concentration ([Ca2+]i) have been observed in a variety of cell types. In the present study, we constructed a mathematical model to simulate the caffeine-induced [Ca2+]i oscillations based on experimental data obtained from isolated type I horizontal cell of carp retina. The results of model analysis confirm the notion that the caffeine-induced [Ca2+]i oscillations involve a number of cytoplasmic and endoplasmic Ca2+ processes that interact with each other. Using this model, we evaluated the importance of store-operated channel (SOC) in caffeine-induced [Ca2+]i oscillations. The model suggests that store-operated Ca2+ entry (SOCE) is elicited upon depletion of the endoplasmic reticulum (ER). When the SOC conductance is set to 0, caffeine-induced [Ca2+]i oscillations are abolished, which agrees with the experimental observation that [Ca2+]i oscillations were abolished when SOC was blocked pharmacologically, verifying that SOC is necessary for sustained [Ca2+]i oscillations.
RESOLVING DOPPLER-FACTOR CRISIS IN ACTIVE GALACTIC NUCLEI: NON-STEADY MAGNETIZED OUTFLOWS

Magnetically driven non-stationary acceleration of jets in active galactic nuclei results in the leading parts of the flow being accelerated to much higher Lorentz factors than in the case of steady-state acceleration with the same parameters. The higher Doppler-boosted parts of the flow may dominate the high-energy emission of blazar jets. We suggest that highly variable GeV and TeV emission in blazars is produced by the faster moving leading edges of highly magnetized non-stationary ejection blobs, while the radio data trace the slower-moving bulk flow. Thus, the radio and gamma-ray emission regions have different, but correlated, Doppler factors. High-energy emission is generated, typically within the optically thick core, in the outer parts of the broad-line emission region, avoiding the radiative drag on the faster parts of the flow. The radio emission should correlate with the gamma-ray emission, delayed with frequency-dependent time lag of the order of weeks to months. Model predictions compare favorably with the latest Fermi γ-ray and MOJAVE radio very long baseline interferometry results.