Miracle-dz/UniFAR-FTUs huggingface dataset:
Industrie 4.0 : eine Standortbestimmung der Automobil- und Fertigungsindustrie

Seit Ende des 18. Jahrhunderts haben industrielle Revolutionen immer wieder fur fundamentale Veranderungen in Wirtschaft und Gesellschaft gesorgt. Herbeigefuhrt wurden sie stets durch neue Technologien oder innovative Organisations-strukturen: Wasser- und Dampfkraft ermoglichten die Mechanisierung, eine umfas-sende Arbeitsteilung war die Basis fur Massenproduktion und mithilfe der Mikroelektronik konnten Maschinen und Anlagen automatisiert werden. Heute stehen wir am Anfang der vierten industriellen Revolution. Gekennzeichnet ist sie durch die umfassende Vernetzung von Menschen, Maschinen, Ressourcen und Produkten. Dies lasst einen Grad an Autonomie der industriellen Prozesse Wirklichkeit werden, der bislang kaum vorstellbar war. Getrieben wird diese Entwicklung zum einem von Technologien, die eine Kommunikation der unterschiedlichen realen und virtuellen Objekte untereinander erlauben – und zwar uber Kontinente hinweg. Zum anderen erzeugen aktuelle Dynamiken an den Markten einen Druck, der Unternehmen zum Handeln zwingt. Sie mussen mit sich standig wandelnden Anforderungen zurechtkommen – von den Rohstoffpreisen bis zu den Erwartungen der Kunden. Flexibilitat wird damit fur sie in vielerlei Hinsicht zur entscheidenden Fahigkeit. Industrie 4.0 – so das gangige Schlagwort fur die vierte industrielle Revolution – kann diese Fahigkeit erheblich fordern und damit spurbare Wettbewerbsvorteile realisieren. So vermutet auch der High-Tech-Verband BITKOM ein immenses Potenzial und prognostiziert fur das Jahr 2025 eine zusatzliche Wertschopfung von insgesamt 78 Milliarden Euro. Doch wie beurteilen Unternehmen in Deutschland das Thema und wie bereiten sie sich auf die anstehende Revolution vor? Antworten darauf liefert die vorliegende Studie, fur die wir 227 Entscheider aus Automobil- und Fertigungsindustrie befragt haben. Das erstaunlichste Ergebnis: Der Begriff Industrie 4.0 war nicht durchgangig bekannt – insgesamt konnten 24% der Befragten mit der Bezeichnung nichts anfangen, bei den OEM waren es sogar 34%. Ob sich ihr eigenes Unternehmen mit dem Thema beschaftigt, konnten 35% aller Befragten nicht beurteilen. Gleichzeitig zeigt die Studie, dass viele der Technologien und Konzepte, die sich unter Industrie 4.0 subsumieren lassen, als wichtig und nutzlich erachtet werden. Und dennoch: Mit vollem Engagement will sich kaum ein Unternehmen auf den Weg machen. Dazu erscheint vielen der wirtschaftlichen Nutzen noch zu wage und muten die Risiken – Stichwort Sicherheit – zu hoch an.
Infant sleep position: pediatricians' advice to parents.

OBJECTIVE The American Academy of Pediatrics' (AAP) recommendation for side or supine sleep position in healthy babies has generated much controversy. We surveyed primary care physicians to determine the effect of the AAP statement on physician attitude toward infant sleep position and advice to parents. METHODS We sent a 23-question survey to 194 physicians in Western New York. The survey addressed their attitude toward the AAP recommendations and its impact on their advice to parents. RESULTS Of the 149 physicians treating newborns, 121 (82%) completed the questionnaire; 98% were aware of the AAP statement. The most common sources of information were the AAP (86%) and professional literature (77%). Of the respondents, 79% agreed with the AAP statement. Reasons for reservation were lack of data (64%), potential adverse consequences of supine position (52%), and their own experience (47%). Gender, years in practice, and type of reimbursement did not influence attitude toward the AAP recommendation. The AAP statement increased the frequency with which physicians routinely discussed sleep position from 34 to 70% (P < .02). Physicians recommending the prone position decreased from 57 to 7% (P < .001), while those recommending supine sleep position increased from 10 to 42% (P < .001). CONCLUSIONS Most physicians agreed with the AAP statement and more frequently discussed sleep position following the AAP recommendations. However, they did not routinely recommend supine sleep position. The majority (69%) recommended the side position even though it is unstable. Although the AAP statement has increased discussion of infant sleep position by primary care physicians in WNY, only a minority recommend that infants sleep supine.
Structural Studies of Several Distinct Metastable Forms of Amorphous Ice

Structural changes during annealing of high-density amorphous ice were studied with both neutron and x-ray diffraction. The first diffraction peak was followed from the high- to the low-density amorphous form. Changes were observed to occur through a series of intermediate forms that appear to be metastable at each anneal temperature. Five distinct amorphous forms were studied with neutron scattering, and many more forms may be possible. Radial distribution functions indicate that the structure evolves systematically between 4 and 8 angstroms. The phase transformations in low-temperature liquid water may be much more complex than currently understood.
Antiangiogenic and Toxic Effects of Genistein, Usnic Acid, and Their Copper Complexes in Zebrafish Embryos at Different Developmental Stages

Angiogenesis plays a major role in the normal embryonic development and in diseases such as cancer. Drugs that control angiogenesis are an alternative way to tackle this disease. The polyphenols usnic acid (3), genistein (5), and daidzein (6) were tested for antiangiogenic and unwanted effects in zebrafish embryos whose blood vessel system resembles that of mammals. The established tyrosine kinase inhibitors axitinib (1) and tyrphostin AG490 (2) were included for comparison. All compounds except 6 caused distinct antiangiogenic effects such as a concentration‐dependent reduction of intersegmental vessels, dorsal longitudinal anastomotic vessels, subintestinal veins and secondary sprouts. As side effects, pericardial oedema and the impairment of blood flow were observed. Usnic acid (3), genistein (5) and Cu(II)‐genisteinate (7) gave rise to a curvature of the spine. Compounds 5 and 7 also induced cell death in the head of the embryos at higher doses. All effects were more pronounced when the compounds had been applied at an early stage (24 hpf) rather than at 48 hpf. The copper complexes 4 and 7 showed a stronger antiangiogenic effect than the free ligands 3 and 5. The genistein complex 7 was antiangiogenic at doses so low that side effects were tolerable, and thus it may be a potential anticancer drug candidate.
Stability Analysis of Swarms With General Topology

This paper investigates the stability and boundary of a swarm with a general directed and weighted topology. The stability of a swarm is generally considered as cohesiveness. We construct a symmetric eigenmatrix and define an orthogonal eigenparameter which reflects the degree of orthogonality between the left eigenvector of the coupling matrix corresponding to its zero eigenvalue and the eigenvectors of the eigenmatrix corresponding to its nonzero eigenvalues. We prove that, if the topology of the underlying swarm is strongly connected, the swarm is then stable in the sense that all agents will globally and exponentially converge to a hyperellipsoid in finite time, both in open space and profiles, whether the center of the hyperellipsoid is moving or not. The swarm boundary and convergence rate are characterized by the eigenparameters of the swarm, which reveals the quantitative relationship between the swarming behavior and characteristics of the coupling topology.
Evaluation of a Late Summer Imazapyr Treatment for Managing Giant Reed ( Arundo donax )

Giant reed has invaded riparian habitats throughout California and the United States. Imazapyr, which can be used for California habitats with an appropriate application regime, has only been recently approved for use in controlling this species in California; therefore, little published data exists on its efficacy. We monitored a site where imazapyr had been applied with the purpose of testing the hypothesis that a 1.5% solution of imazapyr applied as a foliar spray was effective at killing giant reed. Plants treated with 1.5% imazapyr had reduced leaf chlorophyll content less than 30 days after treatment but recovered the following spring. Treatment with 1.5% imazapyr did not significantly reduce the proportion of living stems or prevent the production of new stems during the spring following treatment. 1
The diagnostic value of calcitonin measurement in wash-out fluid from fine-needle aspiration of thyroid nodules in the diagnosis of medullary thyroid cancer.

OBJECTIVES The diagnostic value of calcitonin measurement in fine-needle aspiration biopsy (FNAB) wash-out fluid (Ct-FNAB) for medullary thyroid cancer (MTC) remains to be determined. This prospective study aimed to assess the diagnostic value of Ct-FNAB in thyroid nodules in comparison with basal serum calcitonin (Ct), pentagastrin-stimulated Ct (Pg-sCt), and cytology. METHODS Among patients with goiter addressed with US-FNAB who had an initial clinical suggestion for thyroidectomy, 27 patients with thyroid nodule/s (n = 60) and normal, borderline, or increased Ct fulfilled the criteria for thyroidectomy. All 27 patients (enrolled according to exclusion/inclusion criteria) underwent ultrasonography (US), Ct, Pg-sCt, US-assisted FNAB of each patient's nodule for both cytology, and Ct-FNAB before thyroidectomy. RESULTS Ct-FNAB always resulted in >1,000 pg/mL in MTC nodules at histology. For values between 36 and 1,000 pg/mL, MTCs and nodular or micronodular C-cell hyperplasia (CCH) results overlapped. Most of the nodules without MTC and/or CCH had Ct-FNAB ≤ 17 pg/mL. Ct-FNAB diagnostic power was superior to and similar to other diagnostic procedures (Ct, Pg-sCt, and cytology) in identifying both MTC and CCH, and MTC alone, respectively. CONCLUSION The diagnostic power of Ct-FNAB is valuable compared with other routine procedures. Ct-FNAB is highly reliable for the early detection and accurate localization of MTC in thyroid nodules, but it does not differentiate between MTC and CCH. Ct-FNAB is an extremely valuable diagnostic tool, especially considering that other diagnostic procedures do not provide a definitive diagnosis, and it can be included in the clinical work-up of thyroid nodules when MTC is suspected.
Prevalence and Causes of Visual Impairment in Adults in Binhu District, Wuxi, China

Background Previously reported data has guided the treatment and prevention of blindness. This study aimed to evaluate the current prevalence and causes of visual impairment among adults who were 50 years old and older in the Binhu District of Wuxi City, China. Material/Methods A randomized sample of stratified clusters was used to analyze individuals from 30 basic sampling units in Wuxi Binhu District. Visual impairment was defined according to World Health Organization (WHO) standards. Results A total of 6725 people who were at least 50 years old participated in this study. According to WHO standards, bilateral low vision and blindness prevalence were both higher in women than in men (low vision: 6.5% vs. 5.2%; and blindness: 1.4% vs. 0.8%; P=0.022 and P=0.039, respectively). The incidence of bilateral visual impairment increased significantly with age (P<0.001 and P<0.001, respectively). Further studies showed that the main causes of bilateral low vision were cataract, high myopic macular degeneration (MMD), and age-related macular degeneration (AMD). The main causes of bilateral blindness were cataract, MMD, and eye loss/atrophy, while the main causes of monocular low vision were cataract, MD, and AMD. The main causes of monocular blindness were cataract, eye loss/atrophy, and AMD. Conclusions The prevalence of low vision and blindness remains high in the Binhu District of Wuxi City in China, especially among older women. In our study, cataracts were the leading cause of visual impairment. Our study highlights that some efforts should be initiated to prevent and treat blindness and low vision. Additional causes of visual impairment were MMD, AMD, and eye loss/atrophy.
Relating Collaborative Technology Use to Teamwork Quality and Performance: An Empirical Analysis

Although team-based work systems are pervasive in the workplace, the use of collaborative systems designed to facilitate and support ongoing teamwork is a relatively recent development. An understanding of how teams embrace and use such collaborative systems - and the relationship of that usage to teamwork quality and team performance - is critical for organizational success. We present a theoretical model in which usage of a collaborative system intervenes between teamwork quality and team performance for tasks that are supported by the system. We empirically validate the model in a setting where established teams voluntarily used a collaborative system over a four-month period to perform tasks with measurable outcomes. Our principal finding is that collaborative system use intervenes between teamwork quality and performance for tasks supported by the system but not for unsupported tasks.
Design and optimization of fractional slot concentrated winding permanent magnet machines for class IV electric vehicles

The design, optimization and application of a number of surface mounted fractional slot concentrated winding (FSCW) electric machines for application to Class IV electric vehicles have been considered. Four FSCW motors with nominal power ratings of 50, 65, 75 and 100 kW have been designed. The motors were optimized using a novel multi-objective optimization strategy which allows a large numbers of objectives to be considered while ensuring computational efficiency and Pareto optimality. Vehicle simulations were carried out using the optimized motors for some typical drive cycles. The gear ratio of the drive train was optimized for each motor with respect to the drive cycle and the vehicle performances were calculated. The methodology and results presented provide a novel and improved framework for considering the trade-offs between the motor size, gear ratio and vehicle performance for Class IV and other vehicle classes.
A Naturally Occurring Mutation in the SLC21A6Gene Causing Impaired Membrane Localization of the Hepatocyte Uptake Transporter*

The organic anion transporter SLC21A6 (also known as OATP2, OATP-C, or LST-1) is involved in the hepatocellular uptake of a variety of endogenous and xenobiotic substances and drugs. We analyzed 81 human liver samples by immunoblotting and found one with a strongly reduced amount of SLC21A6 protein suggesting mutations in theSLC21A6 gene. The SLC21A6 cDNA from this sample contained five base pair changes in one allele; three of the mutations resulted in amino acid substitutions designated SLC21A6-N130D, SLC21A6-P155T, and SLC21A6-L193R. The former two were polymorphisms (SLC21A6*1b and SLC21A6*4), whereas SLC21A6-L193R represents the first naturally occurring mutation identified in one allele of the SLC21A6 gene, which affects protein maturation and organic anion transport. We introduced each of the mutations into the SLC21A6 cDNA and established stably transfected MDCKII cells expressing the respective mutant SLC21A6 protein. Immunofluorescence microscopy and uptake measurements were used to study localization and transport properties of the mutated proteins. Both proteins carrying the polymorphisms were sorted to the lateral membrane like wild-type SLC21A6, but their transport properties for the substrates cholyltaurine and 17β-glucuronosyl estradiol were altered. Importantly, most of the mutant protein SLC21A6-L193R was retained intracellularly, and this single amino acid exchange abolished transport function.
Determination of Optimal Machining Parameters of Massive Wooden Edge-Glued Panels Made of European larch (Larix decidua Mill.) using Taguchi Design Method

In this paper, the optimization of computer numerical control (CNC) machining parameters were conducted using the Taguchi design method on the surface quality of massive wooden edge glued panels (EGP) made of European larch (Larix decidua Mill). Three machining parameters and their effects on surface roughness were evaluated. These parameters included tool clearance strategy, spindle speed, and feed rate. An analysis of variance (ANOVA) was performed to identify the significant factors affecting the surface roughness (Ra and Rz). Optimum machining parameter combinations were acquired by conducting an analysis of the signal-to-noise (S/N) ratio. Optimal cutting performance for the Ra and Rz was obtained for the cutter at a tool clearance strategy of an offset 16000 rpm spindle speed and 1000 mm/min feed rate. The surface roughness, both the Ra and Rz, increased with increasing feed rate. Optimal cutting performance for Ra and Rz was obtained for a tool clearance strategy of an offset 16000 rpm spindle speed, and 1000 mm/min feed rate cutting settings. Based on the confirmation tests, Ra decreased 2.2 times and Rz 1.8 times compared to the starting cutting parameters.
Modification of bitter taste in children.

The palatability of oral medications, many of which are quite bitter, plays an important role in achieving compliance in pediatric patients. We tested the hypothesis that the addition of a sodium salt to some, but not all, bitter tasting liquids enhances acceptance and reduces the perceived bitterness in 7- to 10-year-old children and their mothers. For both children and adults, sodium gluconate significantly suppressed the perceived bitterness and enhanced the acceptance of urea and caffeine whereas the reverse was true for another bitter stimulus, Tetralone. Because children preferred salted solutions more than did adults, these data suggest that the use of sodium salts may be an especially effective strategy for reducing the bitterness of some medicines and facilitating compliance among pediatric populations. However, based on sodium's differential ability to inhibit bitterness, as has been shown here with children and adults, clearly each drug of interest must be evaluated separately.
On the Efficient Simulation of Outage Probability in a Log-Normal Fading Environment

The outage probability (OP) of the signal-to-interference-plus-noise ratio (SINR) is an important metric that is used to evaluate the performance of wireless systems. One difficulty toward assessing the OP is that, in realistic scenarios, closed-form expressions cannot be derived. This is, for instance, the case of the Log-normal environment, in which evaluating the OP of the SINR amounts to computing the probability that a sum of correlated Log-normal variates exceeds a given threshold. Since such a probability does not admit a closed-form expression, it has thus far been evaluated by several approximation techniques, the accuracies of which are not guaranteed in the region of small OPs. For these regions, simulation techniques based on variance reduction algorithms are a good alternative, being quick and highly accurate for estimating rare event probabilities. This constitutes the major motivation behind this paper. More specifically, we propose a generalized hybrid importance sampling scheme, based on a combination of a mean shifting and a covariance matrix scaling, to evaluate the OP of the SINR in a Log-normal environment. We further our analysis by providing a detailed study of two particular cases. Finally, the performance of these techniques is performed both theoretically and through various simulation results.
Subthreshold and micropulse diode laser photocoagulation

Retinal laser photocoagulation is a proven, effective treatment for various retinal disorders. Common clinical protocols use intra-operatively visible endpoints that cause iatrogenic chorioretinal damage. For this reason, laser therapy is normally limited to levels of disease severity for which the benefit-to-risk ratio justifies its application. The use of 810 nm diode lasers in the MicroPulse mode offers the surgeon the possibility to minimize iatrogenic retinal damage. A less destructive laser therapy with a more favorable benefit-to-risk ratio could justify treatment earlier in the course of the disease, allowing for stabilization or improvement of less compromised visual functions.
The Kutcher Adolescent Depression Scale: assessment of its evaluative properties over the course of an 8-week pediatric pharmacotherapy trial.

OBJECTIVE Self-report instruments commonly used to assess depression in adolescents have limited or unknown psychometric properties in this age group. We report the evaluative properties of the Kutcher Adolescent Depression Scale (KADS), a self-report scale designed specifically for identifying depressed adolescents and for monitoring symptom severity over time. METHODS One hundred and six adolescents with major depression disorder (MDD) enrolled in an 8-week, double-blind, placebo-controlled study of paroxetine. Efficacy assessments were conducted on days 0 (baseline), 7, 14, 21, 28, 42, and 56 using the self-rated KADS and the clinician-rated Children's Depression Rating Scale-Revised (CDRS-R), Clinical Global Impression (CGI) of severity, and Global Assessment of Functioning (GAF) scale. The data were initially examined to establish which of the 16 KADS items showed greatest sensitivity to change. Subsequent analyses then compared the evaluative properties of three versions of the KADS: the full-length KADS, a six-item subscale previously established as a screening tool, and an 11-item subscale optimized for sensitivity to change. RESULTS Within-subject correlations among subjects' KADS scores and their clinician-rated scale scores showed that clinician-rated changes in severity were significantly better corroborated by the 11-item KADS (mean correlations with the CDRS-R, CGI, and GAF: r = 0.69, 0.60, and -0.70, respectively) than by the six-item KADS (r = 0.62, 0.56, and -0.63, respectively) and at least as well corroborated as by the full-length KADS (r = 0.64, 0.56, and -0.67, respectively). Furthermore, in terms of mean percentage change in scores from day 0 to day 56, the 11-item KADS (59%) significantly outperformed the full-length KADS (46%) and all three clinician-rated scales (43%, 37%, and 29%, respectively) and at least matched the performance of the six-item KADS (56%). CONCLUSIONS These results suggest that the 11-item self-rated KADS is a sensitive measure of treatment outcome in adolescents diagnosed with MDD.
Methodology and Preliminary Results From the Neurocognitive Outcomes of Depression in the Elderly Study

A methodology is presented for following a cohort of older depressed patients to examine neurocognitive outcomes of depression. A total of 265 depressed individuals and 138 healthy, nondepressed controls age 60 and older who completed at least 1 year of follow-up data underwent periodic clinical evaluation by a geriatric psychiatrist. A subset of 141 patients and 137 controls had neuropsychological testing. A consensus panel of experts reviewed 63 depressed subjects with suspected cognitive impairment. Twenty-seven individuals in the depressed group were assigned diagnoses of dementia, including 11 with Alzheimer’s disease, 8 with vascular dementia, and 8 with dementia of undetermined etiology. In addition, 25 individuals had other forms of cognitive impairment, and 11 were considered cognitively normal. Among elderly controls, 2 developed substantial cognitive impairment with clinical diagnoses of dementia. Among the depressed group, the incidence rates for dementia for this age are much higher than would be expected. These results are consistent with prior evidence linking depression and later dementia. Future studies are needed to examine neuroimaging and genetic, clinical, and social predictors of neurocognitive decline in depression.