Miracle-dz/UniFAR-FTUs huggingface dataset:
The impact of positive organisational factors on the career success of black employees in the South African work environment: An exploratory study

This study is rooted in career psychology with implications for career management. In addition, the study draws from various fields including the positive organisational behaviour paradigm. The underlying assumption of this study is that certain organisational and individual factors influence the experience of subjective career success amongst black employees in the South African work environment. In order to evaluate this assumption an attempt was made to gain an understanding of the antecedents of subjective career success. An overview of the literature led the researcher to the conclusion that transformational leadership, job resources, supportive organisational climate, psychological empowerment, and psychological capital (PsyCap), could be regarded as antecedents of subjective career success. Based on the literature, a theoretical model was developed that portrays a sequential process within which the identified variables play roles that vary in salience, depending on the stage in the sequential process. A mixed-methods research design was employed to guide the investigation. More specifically, the study consisted of a qualitative strand, followed by two quantitative strands. In the qualitative strand (Phase 1), a semi-structured interview was used to obtain information about the factors influencing career success from 30 black employees in white-collar jobs from three different South African organisations. The purpose of the qualitative strand was two-fold, firstly to seek confirmation that the instruments utilised covered the most salient issues. Secondly, to obtain guidance on how to supplement constructs that were not adequately covered, before continuing with the subsequent quantitative strands. The outcome of Phase 1 provided evidence of sufficient coverage of the variables as based on the literature review. However, it was decided to add three questions to the job resources measuring instrument, as well as two items to the supportive organisational climate instrument. During both the quantitative strands, survey research was used. To facilitate the collection of data during the survey research, an electronic web-based questionnaire Stellenbosch University http://scholar.sun.ac.za
Climate Impact on Plankton Ecosystems in the Northeast Atlantic

It is now widely accepted that global warming is occurring, yet its effects on the world's largest ecosystem, the marine pelagic realm, are largely unknown. We show that sea surface warming in the Northeast Atlantic is accompanied by increasing phytoplankton abundance in cooler regions and decreasing phytoplankton abundance in warmer regions. This impact propagates up the food web (bottom-up control) through copepod herbivores to zooplankton carnivores because of tight trophic coupling. Future warming is therefore likely to alter the spatial distribution of primary and secondary pelagic production, affecting ecosystem services and placing additional stress on already-depleted fish and mammal populations.
Using Tool-Supported Model Based Safety Analysis -- Progress and Experiences in SAML Development

Software controls in technical systems are becoming more and more important and complex. Model based safety analysis can give provably correct and complete results, often in a fully automatic way. These methods can answer both logical and probabilistic questions. In common practice, the needed models must be specified in different input languages of different tools depending on the chosen verification tool for the desired aspect. This is time consuming and error-prone. To cope with this problem we developed the safety analysis modeling language (SAML). In this paper, we present a new tool to intuitively create probabilistic, non-deterministic and deterministic specifications for formal analysis. The goal is to give tool-support during modeling and thus make building a formal model less error-prone. The model is then automatically transformed into the input language of state of the art verification engines. We illustrate the approach on a case-study from nuclear power plant domain.
A Bioeconomic View of the Neolithic Transition to Agriculture

Adoption of agriculture at the expense of hunting and gathering was the dramatic precondition for all modern civilization. Recent data suggest that, because of this transition, humans initially were more disease prone, smaller, less nourished, and shorter-lived. To explain why individuals chose agriculture over hunting and gathering, this paper develops a simple model of the evolution of preferences over the quality and quantity of children, as would have been generated by our long history as a species. These preferences would have induced the choice of agriculture, but also would have led to these otherwise puzzling health effects.
Analysing Service Quality in the Hospitality Industry Using the SERVQUAL Model

This study reports an application in the hospitality industry of the SERVQUAL model developed by Parasuraman, Zeithaml and Berry. Although originally developed for application within the financial services sector, the model is designed to measure those components of service that generate satisfaction within five dimensions. This study identified the existence of gaps between clients' and management perceptions of attributes of the hotel, and between client expectation and perception of the services offered. It is argued that the existence of these gaps is a source of dissatisfaction with services provided. Factor analysis identified five dimensions explaining 78 per cent of variance, but these differed from the SERVQUA L model.
The Pricing of Stock Index Options in a General Equilibrium Model

Abstract This paper analyzes the pricing of stock index options in a simple general equilibrium model. In this model, the volatility of the stock index and the spot rate of interest are functions of a stochastic variable. The paper investigates the biases that arise when using the Black-Scholes model with the assumed volatility and interest rate dynamics. It is shown that the model can, in principle, explain the biases observed in empirical work on stock index options.
Continuous Predictive Modeling—A Comparative Analysis

We evaluate the performance of several predictive models to analyze continuous response vis-à-vis the performance of a discrete-choice logistic regression model. The models were evaluated based on three measures—profitability analysis, goodness-of-fit criteria, and prediction accuracy. The evaluation was conducted on a real application involving an honme equity loan campaign in the banking industry. The implications of the results for decision making are also discussed.
The contribution of increases in family benefits to Australia's early 21st-century fertility increase: An empirical analysis

Between 2001 and 2008 Australia’s total fertility increased from 1.73 to 1.96. This period also saw changes to family benefits, most notably the introduction of a universal, flat-rate at birth payment and an increased subsidisation of child care. This paper analyses individual-level fertility, using data from a large-scale longitudinal survey and focusing on the effects of changes to family benefits, macroeconomic variables, entitlements to family-friendly working conditions, and socioeconomic and demographic characteristics. It finds the effects of the ‘Baby Bonus’ and the Child Care Rebate are slight. The effects of education, income, occupation, marital status, age and parity are significant.
ATP and fructose‐2,6‐bisphosphate regulate skeletal muscle 6‐phosphofructo‐1‐kinase by altering its quaternary structure

Recently, it has been demonstrated that fructose‐2,6‐bisphosphate (F2,6BP) protects skeletal muscle 6‐phosphofructo‐1‐kinase (PFK) from thermal inactivation (50 °C) and against the deleterious effects of guanidinium hydrochloride (GdmCl). On the other hand, ATP, when added at its inhibitory concentrations, that is, >1 mM, enhanced either the thermal‐ or GdmCl‐induced inactivation of PFK. Moreover, we concluded that these phenomena were probably due to the stabilization of PFK tetrameric structure by F2,6BP, and the dissociation of this structure into dimers induced by ATP. Aimed at elucidating the effects of F2,6BP and ATP on PFK at the structural and functional levels, the present work correlates the effects of these metabolites on the equilibrium between PFK dimers and tetramers to the regulation promoted on the enzyme catalytic activity. We show that ATP present a dual effect on PFK structure, favoring the formation of tetramer at stimulatory concentrations (up to 1 mM), and dissociating tetramers into dimers at inhibitory concentrations (>1 mM). Furthermore, F2,6BP counteracted this later ATP effect at either the structural or catalytic levels. Additionally, the effects of both F2,6BP or ATP on the equilibrium between PFK tetramers and dimers and on the enzyme activity presented a striking parallelism. Therefore, we concluded that modulation of PFK activity by ATP and F2,6BP is due to the effects of these ligands on PFK quaternary structure, altering the oligomeric equilibrium between PFK tetramers and dimers. © 2008 IUBMB IUBMB Life, 60(8): 526–533, 2008
Pharmacokinetics of paclitaxel and metabolites in a randomized comparative study in platinum-pretreated ovarian cancer patients.

PURPOSE To investigate the pharmacokinetics and pharmacodynamics of paclitaxel in a randomized comparative study with four different treatment arms in patients with platinum-pretreated ovarian carcinoma. PATIENTS AND METHODS Eighteen patients were entered onto this study in which paclitaxel was administered at a high dose of 175 mg/m2 versus a low dose of 135 mg/m2 on a 3- or 24-hour infusion schedule. A solid-phase extraction technique for sample pretreatment followed by a reverse-phase high-performance liquid chromatographic (HPLC) assay was used for analysis of plasma. RESULTS Grade 3 neutropenia occurred in all four treatment arms. However, it was more severe on the 24-hour infusion schedule. Paclitaxel concentrations as low as 0.012 mumol/L were measured with the HPLC assay. With this low quantitation threshold, we found the plasma disappearance of paclitaxel to be triphasic, with half-lives t1/2(alpha), t1/2(beta), and t1/2(gamma) mean values for the different treatment arms of 0.19 hours (range, 0.01 to 0.4), 1.9 hours (range, 0.5 to 2.8), and 20.7 hours (range, 4 to 65), respectively. Eleven possible metabolites were found, of which three were identified as taxanes by on-line HPLC-photodiode array (PDA) detection. Investigation of pharmacodynamics shows no clear relationship between the pharmacokinetic parameters area under the plasma concentration time curve (AUC), area under the plasma concentration moment curve (AUMC), maximal plasma concentration (Cmax), clearance, and toxicity. However, a relationship was found between the duration of plasma concentrations above a threshold of 0.1 mumol/L with absolute neutrophil count (ANC) and white blood cell count (WBC). CONCLUSION Paclitaxel is metabolized, and putative metabolic products can be found in plasma of patients treated with the drug. Our results indicate that myelosuppression can be predicted by the measurement of the duration of plasma concentrations above the threshold of 0.1 mumol/L.
Performance benchmarks for diagnostic mammography.

PURPOSE To evaluate a range of performance parameters pertinent to the comprehensive auditing of diagnostic mammography examinations, and to derive performance benchmarks therefrom, by pooling data collected from large numbers of patients and radiologists that are likely to be representative of mammography practice in the United States. MATERIALS AND METHODS Institutional review board approval was met, informed consent was not required, and this study was Health Insurance Portability and Accountability Act compliant. Six mammography registries contributed data to the Breast Cancer Surveillance Consortium (BCSC), providing patient demographic and clinical information, mammogram interpretation data, and biopsy results from defined population-based catchment areas. The study involved 151 mammography facilities and 646 interpreting radiologists. The study population included women 18 years of age or older who underwent at least one diagnostic mammography examination between 1996 and 2001. Collected data were used to derive mean performance parameter values, including abnormal interpretation rate, positive predictive value (for abnormal interpretation, biopsy recommended, and biopsy performed), cancer diagnosis rate, invasive cancer size, and the percentages of minimal cancers, axillary node-negative invasive cancers, and stage 0 and I cancers. Additional benchmarks were derived for these performance parameters, including 10th, 25th, 50th (median), 75th, and 90th percentile values. RESULTS The study involved 332,926 diagnostic mammography examinations. Mean performance parameter values were abnormal interpretation rate, 8.0%; positive predictive value for abnormal interpretation, 31.4%; positive predictive value for biopsy recommended, 31.5%; positive predictive value for biopsy performed, 39.5%; cancer diagnosis rate, 25.3 per 1000 examinations; invasive cancer size, 20.2 mm; percentage of minimal cancers, 42.0%; percentage of axillary node-negative invasive cancers, 73.6%; and percentage of stage 0 and I cancers, 62.4%. CONCLUSION The presented BCSC outcomes data and performance benchmarks may be used by mammography facilities and individual radiologists to evaluate their own performance for diagnostic mammography as determined by means of periodic comprehensive audits.
The relationship between consumer orientation, service value, medical care service quality and patient satisfaction: The case of a medical center in Southern Taiwan

The competition among hospitals in Taiwan has become more and more intense, especially since National Health Insurance has come into effect. The number of so-called “mega” hospitals is growing while the number of patients is limited. In this competitive environment, hospitals have to carry out their business not only by maintaining the balance between quality and cost, but also by increasing interaction with their customers (patients). Customer-oriented services are what will give hospitals their core competitive edge for sustainable development. The key to maintain good relationships with customers is based on analyzing data related to customer satisfaction, strengthening medical service quality and providing tailor-made service. By doing so, hospitals can develop a more valuable relationship with their customers. This study was conducted by questionnaire. The purpose is to examine the correlation between customer orientation, medical service quality, service value and patient satisfaction in relation to medical service providers located in southern Taiwan. The data were analyzed with statistical methods such as Pearson’s correlation analysis, linear structure relation and analysis of variance. Our findings indicate that: (1) Customer orientation, medical service quality and value of patients are positively related to each other and patient satisfaction is influenced by these three constructs and; (2) There are significant differences shown by patients with different perceptions of customer orientation in relation to service quality and patient satisfaction constructs and so on, but no difference in relation to service constructs. Key words: Consumer orientation, service value, medical care service quality, patient satisfaction.
The Stock Return Comovements: A Study of the European and the Japanese Equity Markets

In this paper, the time-series developments of covariations of returns between the Japanese stock markets and the European stock markets are empirically examined. We analyze these comovements by dividing sample periods into several terms that are before and after the Lehman Shock in the US. In this study, it is firstly clarified that the linkage of stock returns of the Japanese markets and the European markets recently gradually increased. Moreover, it is secondly identified that in the period right after the US Lehman Shock, the covariations between stock returns in Japan and in several European countries highly increased.
Recovery of Contractile Function of Stunned Myocardium in Chronically Instrumented Dogs is Enhanced by Halothane or Isoflurane

Following brief periods (5–15 min) of total coronary artery occlusion and subsequent reperfusion, despite an absence of tissue necrosis, a decrement in contractile function of the postischemic myocardium may nevertheless be present for prolonged periods. This has been termed “stunned” myocardium to differentiate the condition from ischemia or infarction. Because the influence of volatile anesthetics on the recovery of postischemic, reperfused myocardium has yet to be studied, the purpose of this investigation was to compare the effects of halothane and isoflurane on systemic and regional hemodynamics following a brief coronary artery occlusion and reperfusion. Nine groups comprising 79 experiments were completed in 42 chronically instrumented dogs. In awake, unsedated dogs a 15-min coronary artery occlusion resulted in paradoxical systolic lengthening in the ischemic zone. Following reperfusion active systolic shortening slowly returned toward control levels but remained approximately 50% depressed from control at 5 h. In contrast, dogs anesthetized with halothane or isoflurane (2% inspired concentration) demonstrated complete recovery of function 3–5 h following reperfusion. Because the anesthetics directly depressed contractile function, additional experiments were conducted in which a 15-minute coronary artery occlusion was produced during volatile anesthesia; however, each animal was allowed to emerge from the anesthetized state at the onset of reperfusion. Similar results were obtained in these experiments, demonstrating total recovery of contractile function within 3–5 h following reperfusion. Thus, despite comparable degrees of contractile dysfunction during coronary artery occlusion in awake and anesthetized dogs, the present results demonstrate that halothane and isoflurane produce marked improvement in the recovery of segment function following a transient ischemic episode. Therefore, volatile anesthetics may attenuate postischemic left ventricular dysfunction occurring intraoperatively and enhance recovery of regional wall motion abnormalities during reperfusion.
Domestic Effects of the Foreign Activities of U.S. Multinationals

Do firms investing abroad simultaneously reduce their domestic activity? This paper analyzes the relationship between the domestic and foreign operations of US manufacturing firms between 1982 and 2004 by instrumenting for changes in foreign operations with GDP growth rates of the foreign countries in which they invest. Estimates produced using this instrument indicate that 10 percent greater foreign investment is associated with 2.6 percent greater domestic investment, and 10 percent greater foreign employee compensation is associated with 3.7 percent greater domestic employee compensation. These results do not support the popular notion that expansions abroad reduce a firm's domestic activity, instead suggesting the opposite. (JEL F23, H25, L25)
Use of 1,320 nm Nd:YAG laser for wrinkle reduction and the treatment of atrophic acne scarring in Asians

The role of 1,320 Nd:YAG in non‐ablative skin rejuvenation in Asians is has not been established. Furthermore, no study has investigated the effectiveness of 1,320 Nd:YAG laser in the treatment of atrophic scarring in Asians. The objective of our study was to investigate the effectiveness of 1,320 Nd:YAG laser in wrinkle reduction and the treatment of atrophic acne scarring in Asians.
“French Phage Network”—Second Meeting Report

The study of bacteriophages (viruses of bacteria) includes a variety of approaches, such as structural biology, genetics, ecology, and evolution, with increasingly important implications for therapeutic and industrial uses. Researchers working with phages in France have recently established a network to facilitate the exchange on complementary approaches, but also to engage new collaborations. Here, we provide a summary of the topics presented during the second meeting of the French Phage Network that took place in Marseille in November 2016.
Carbon Dioxide Emission Pathways Avoiding Dangerous Ocean Impacts

AbstractAnthropogenic emissions of greenhouse gases could lead to undesirable effects on oceans in coming centuries. Drawing on recommendations published by the German Advisory Council on Global Change, levels of unacceptable global marine change (so-called guardrails) are defined in terms of global mean temperature, sea level rise, and ocean acidification. A global-mean climate model [the Aggregated Carbon Cycle, Atmospheric Chemistry and Climate Model (ACC2)] is coupled with an economic module [taken from the Dynamic Integrated Climate–Economy Model (DICE)] to conduct a cost-effectiveness analysis to derive CO2 emission pathways that both minimize abatement costs and are compatible with these guardrails. Additionally, the “tolerable windows approach” is used to calculate a range of CO2 emissions paths that obey the guardrails as well as a restriction on mitigation rate. Prospects of meeting the global mean temperature change guardrail (2° and 0.2°C decade−1 relative to preindustrial) depend strongly on .
Corruption, Optimal Taxation, and Growth

How does the presence of corruption affect the optimal mix between consumption and income taxation? In this article, the authors examine this issue using a simple neoclassical growth model, with a self-seeking and corrupt public sector. They find that the optimal tax mix in a corrupt economy is one that relies more heavily on consumption taxes than on income taxes, relative to an economy without corruption. Their model also allows them to investigate the effect of corruption on the optimal (or welfare-maximizing) size of government, and their results indicate that the optimal size of government balances the wishes of the corrupt public sector for a larger government, and so greater opportunities for corruption, with those in the private sector who prefer a smaller government. Not surprisingly, the optimal size of government is smaller in an economy with corruption than in one without corruption.
Sexual orientation and tobacco use in a cohort study of US adolescent girls and boys.

OBJECTIVE To examine sexual-orientation group disparities in tobacco use in adolescent girls and boys. DESIGN Survey data from 10685 adolescent girls and boys participating in 1999 in the Growing Up Today Study were examined cross-sectionally. SETTING Community-based population of adolescents living throughout the United States. Main Outcome Measure Prevalence of tobacco use. RESULTS Ninety-two percent of the participants described themselves as heterosexual (n = 9296), 5% as mostly heterosexual (n = 511), 1% as lesbian/gay/bisexual (n = 103), and 2% as unsure (n = 226). Ages ranged from 12 to 17 years. Compared with heterosexuals, mostly heterosexual girls were 2.5 (95% confidence interval, 1.8-3.5), lesbian/bisexual girls were 9.7 (95% confidence interval, 5.1-18.4), and mostly heterosexual boys were 2.5 (95% confidence interval, 1.4-4.6) times more likely to smoke at least weekly. In contrast, gay/bisexual boys were not more likely to smoke. Findings persisted even when controlling for multiple sociodemographic and psychosocial covariates. CONCLUSION Our findings indicate that mostly heterosexual adolescents of both sexes and lesbian/bisexual girls are at heightened risk for tobacco use.