Miracle-dz/UniFAR-FTUs huggingface dataset:
Intramyocardial Injection of Heart Tissue-Derived Extracellular Matrix Improves Postinfarction Cardiac Function in Rats

Aims: We determined whether implantation of heart tissue-derived decellularized matrix, which contains native biochemical and structural matrix composition, could thicken the infarcted left ventricular (LV) wall and improve LV function in a rat myocardial infarction model. Methods and Results: Myocardial infarction was induced by left coronary ligation in Fischer rats. One week later, saline (75 μL, n = 17) or matrix (75 μL, n = 19) was directly injected into the infarcted area. At 6 weeks after injection, cardiac function was assessed by left ventriculogram, echocardiography, and Millar catheter. The hearts were pressure fixed to measure postmortem LV volume and processed for histology. Left ventriculogram demonstrated that LV ejection fraction (EF) was significantly greater in the matrix-treated (56.7% ± 1.4%) than in the saline-treated group (52.4% ± 1.5%; P = .043), and paradoxical LV systolic bulging was significantly reduced in the matrix-treated group (6.2% ± 1.6% of the LV circumference) compared to the saline-treated group (10.3% ± 1.3%; P = .048). Matrix implantation significantly increased the thickness of infarcted LV wall (0.602 ± 0.029 mm) compared to the saline-treated group (0.484 ± 0.03 mm; P = .0084). Infarct expansion index was significantly lower in the matrix-treated group (1.053 ± 0.051) than in the saline-treated group (1.382 ± 0.096, P = .0058). Blood vessel density and c-kit positive staining cells within the infarct area were comparable between the 2 groups. Conclusions: Implantation of heart tissue-derived decellularized matrix thickens the LV infarcted wall, prevents paradoxical LV systolic bulging, and improves LV EF after myocardial infarction in rats. This benefit was not dependent on the enhanced angiogenesis or the recruitment of endogenous stem cells to the injury site.
Trade performance in eastern Europe and central Asia

In the Eastern Europe and Central Asia (ECA) region, countries show great variations in their levels of openness and how intensively they trade. There is a strong and positive correlation in export and import market participation rates and a similar relationship between how intensively firms trade in each market. Using a firm level data set, this note shows that the difference in export intensity between large and small firms is almost 30 percentage points; however, this difference is not seen among all countries. A comparison of industries shows that the garment industry is the most export and import intensive industry in the region. The note then focuses on customs efficiencies and finds that countries with inefficient customs service's export and import less intensively. Finally, this note analyzes how trade has evolved since 2005. The percentage of importers and import intensities have increased among the member countries in the European Union (EU); these statistics exclude the trade of EU countries with each other. In the region overall, import intensity has increased by 10 percentage points; on the other hand, there has not been a significant change in export intensity.
Speech Patterns and Personality

This study briefly reviews the literature on the relation between non-content aspects of speech and personality variables. Data on lengths of sound, silence, units and sound/silence ratio are then presented showing that in general speech patterns of Dutch subjects are similar to those of English-speaking subjects. There is also confirmation of some differences in speech patterns between extraverts and introverts, and some differences were found due to sex and intelligence.
Surgical repair in recurrent dislocation of the ankle joint.

1. Lateral instability of the ankle may be the source of serious disability. 2. The various causes of the lesion are discussed. 3. Attention is called to the pathognomonic feature of the lesion—abnormal tilting of the talus in the joint mortise when the foot is plantar flexed and inverted at the subtalar joint. This is demonstrated in an anteroposterior roentgenogram. 4. The author describes a modifications of the classic Watson-Jones operations of tenodesis combined with reconstruction of the external lateral ligament. This method, which is simpler of execution, has the added advantage of providing greater protection against inversion of the foot by a firm sheet of fascia and retinaculum turned down as a flap and anchored over the newly constructed ligament. 5. Seven patients with chronic instability of the ankle have been treated by the author's method with good results.
Credit at Times of Stress: Latin American Lessons from the Global Financial Crisis

The financial systems in emerging market economies (EMEs) during the 2008-09 global financial crisis performed much better than in previous crisis episodes, albeit with significant differences across regions. For example, real credit growth in Asia and Latin America was less affected than in Central and Eastern Europe. This paper identifies the factors at both the country and the bank levels that contributed to the behaviour of real credit growth in Latin America during the global financial crisis. The resilience of real credit during the crisis was highly related to policies, measures and reforms implemented in the pre-crisis period. In particular, we find that the best explanatory variables were those that gauged the economy's capacity to withstand an external financial shock. Key were balance sheet measures such as the economy's overall currency mismatches and external debt ratios (measuring either total debt or short-term debt). The quality of pre-crisis credit growth mattered as much as its rate of expansion. Credit expansions that preserved healthy balance sheet measures (the "quality" dimension) proved to be more sustainable. Variables signalling the capacity to set countercyclical monetary and fiscal policies during the crisis were also important determinants. Moreover, financial soundness characteristics of Latin American banks, such as capitalisation, liquidity and bank efficiency, also played a role in explaining the dynamics of real credit during the crisis. We also found that foreign banks and banks which had expanded credit growth more before the crisis were also those that cut credit most. The methodology used in this paper includes the construction of indicators of resilience of real credit growth to adverse external shocks in a large number of emerging markets, not just in Latin America. As additional data become available, these indicators could be part of a set of analytical tools to assess how emerging market economies are preparing themselves to cope with the adverse effects of global financial turbulence on real credit growth.
Cyclin D2 controls B cell progenitor numbers

Cyclin D2 affects B cell proliferation and differentiation in vivo. It is rate‐limiting for B cell receptor (BCR)‐dependent proliferation of B cells, and cyclin D2−/− mice lack CD5+(B1) B lymphocytes. We show here that the bone marrow (BM) of cyclin D2−/− mice contains half the numbers of Sca1+B220+ B cell progenitors but normal levels of Sca1+ progenitor cells of other lineages. In addition, clonal analysis of BM from the cyclin D2−/− and cyclin D2+/+ mice confirmed that there were fewer B cell progenitors (B220+) in the cyclin D2−/− mice. In addition, the colonies from cyclin D2−/− mice were less mature (CD19lo) than those from cyclin D2+/+ mice (CD19Hi). The number of mature B2 B cells in vivo is the same in cyclin D2−/− and cyclin D2+/+ animals. Lack of cyclin D2 protein may be compensated by cyclin D3, as cyclin‐dependent kinase (cdk)6 coimmunoprecipitates with cyclin D3 but not cyclin D1 from BM mononuclear cells of cyclin D2−/− mice. It is active, as endogenous retinoblastoma protein is phosphorylated at the cdk6/4‐cyclin D‐specific sites, S807/811. We conclude that cyclin D2 is rate‐limiting for the production of B lymphoid progenitor cells whose proliferation does not depend on BCR signaling.
Toward a Language Modeling Approach for Consumer Review Spam Detection

Numerous reports have indicated the severity of fake reviews (i.e., spam) posted to various e-Commerce or opinion sharing Web sites. Nevertheless, very few studies have been conducted to examine the trustworthiness of online consumer reviews because of the lack of an effective computational methodology. Unlike other kinds of Web spam, untruthful reviews could just look like other legitimate reviews (i.e., ham), and so it is difficult to apply any features to distinguish the two classes. One main contribution of our research work is the development of a novel computational methodology to combat online review spam. Our experimental results confirm that the KL divergence and the probabilistic language modeling based computational model is effective for the detection of untruthful reviews. Empowered by the proposed computational methods, our empirical study found that around 2% of the consumer reviews posted to a large e-Commerce site is spam.
Estimates of genetic parameters and effect of inbreeding on milk yield and composition in South African Jersey cows

The effect of inbreeding on the 305-d yields of milk, fat and protein, and the percentages of fat and protein in the first three lactations was estimated using records on the South African Jersey cows that participated in the National Dairy Animal Improvement Scheme. Inbreeding coefficients were estimated using the entire pedigree records of the Jersey breed and ranged from 0 to 42%. Data were analyzed using a repeatability animal model. The statistical model included the fixed effects of herd-year-season, age of the cow at calving, calving interval, inbreeding as a discrete or continuous variable and random effects of direct additive genetic, permanent environment of the cow and the residual effects. The multitrait derivative-free REML algorithm was used to obtain estimates of the variance components, ratios and empirical best linear unbiased estimates of the effects of inbreeding. Estimates of heritability were 0.26 (±0.009), 0.19 (±0.008), 0.23 (±0.008), 0.39 (±0.009), and 0.53 (±0.009) for milk, fat and protein yields and fat and protein percent, respectively. Corresponding estimates of the ratio of permanent environmental effect of the cow to total phenotypic variance were 0.20 (±0.008), 0.18 (±0.007), 0.21 (±0.007), 0.14 (±0.008) and 0.13 (±0.008). The regression coefficients for yields (kg) of milk, fat and protein were -15.42 (±1.13), -0.64 (±0.05), and -0.59 (±0.04), and 0.0011 (±0.0005) and 0.0003 (±0.0003) for percent (%) of fat and protein for each 1% increase in inbreeding, respectively. These results provide evidence of inbreeding depression for milk yield and composition traits in the South African Jersey population. Keywords : Dairy cattle, inbreeding depression, 305-d yield South African Journal of Animal Science Vol. 38 (2) 2008: pp. 119-125
The marketing orientation of small and medium enterprises: An Australian study

The market orientation construct ha~ emerged as a key marketing theme in the 1990's. While the concept of being focussed on the market (cus! Omcr~ and competitors) ha~ heen known since the early 1950's (e.g. Drucker, 1954}, putting the cnnccpl into practice through a set of specific actio~t~ hu.~ eluded many organi~alions and acadcmJC~. As a result. market oricmation (also termed market focus, customer focus and competitor focus) had remained a business philosophy (Bennett & Cooper, 1979: Felton, 1959: Konopa & Calabro, 197 I) more than a ~trategic approach. While there ha\'C been sporadic anempt~ at defining or operationalising a marketing or customer orientation in the pa~t (Gronroos, 1989; Kotler, 1977; Ma.~iello, 1988; Webster. 1988). the first serious ef! On wa~ in the early 1990's when Kohli and Jaworski ( 1990) and Narver and Slater ( 1990) defined market orientation a~ a set of erganisational activities or behaviour~. Narver and Simer abo found a positive link between h.aving such an orientilliOn and business performance. The empha~is in beth models was on obtaining and understanding customers and competitors and responding to customers' needs better than competitors through a coordinated effort across the organi~ation. Subsequently a number of studies have supported the positive relmionship between market orientation and business performance. However, resul! s have not been con~istent and several variables have been shown to moderate the market oriemationperfonnance relationship. All of the major market orientation studb have been undertaken within large organisations and very little is known about the market orientation of small and medium enterprises (SMEs), or of its relationship to their performance. It is recognised that
Symptom improvement and residual symptoms during acute antidepressant treatment in pediatric major depressive disorder.

OBJECTIVE Knowing the timing of specific depressive symptom improvement will enable clinicians to prepare their patients well and improve treatment outcome, whereas recognizing which depressive symptoms may show delayed improvement will help clinicians to provide additional interventions early in treatment. In a prospective open-label fluoxetine study, we investigated the timing of depressive symptom improvement during acute treatment, and identified common remaining symptoms following 4, 8, and 12 weeks of acute treatment in depressed youths. METHOD A total of 168 children and adolescents, aged 7-18 years, with primary diagnoses of major depressive disorder (MDD) received 12 weeks of fluoxetine treatment. Youths were evaluated using the Kiddie Schedule for Affective Disorders and Schizophrenia. The outcome measure included the Children's Depression Rating Scale-Revised. RESULTS All depressive symptoms improved, particularly during the first 4 weeks of acute treatment. Forty-seven percent of remitters reported at least one residual symptom following 12 weeks, with most common residual symptoms being impaired school performance, insomnia, and irritability. CONCLUSIONS Residual symptoms are common, even among remitters, at the end of 12 weeks of acute treatment. There is a need for clinicians to monitor symptom improvement and potentially provide additional interventions for the more resistant symptoms, such as insomnia and school performance.
The process of implementing aspirational place brands

There is increasing interest on the part of governments and associated agencies in place branding the practice of applying marketing and brand principles to geographic entities. While existing literature advocates the need and benefits of place branding, there is a call for more empirical research particularly into the process of implementing a place brand. Contemporary authors refer to the similarities between the more developed literature on corporate brand and that of the place brand. However, in both domains there remains a need for greater understanding of the process of engaging and harmonising multiple stakeholders towards the acceptance of an adopted brand strategy. This study addresses this need. This research investigates the process of place brand implementation in a number of locations which have applied a place brand strategy and applies an inductive methodology to this new domain of place branding and identifies through case study research, stages that are important to the place brand implementation process. The research provides empirical evidence and a suggested framework for the implementation of a place brand strategy. Further, this work contributes to the extant literature on place branding and the improvement of professional practice, assisting those who have the responsibility to effectively implement a place brand strategy. As a result of this study it is concluded that there is a process, consisting of stages, which are necessary to improve the likelihood of successful place brand implementation. The stages of implementation developed as a result of this research have been identified as activating, energising, concepting, expanding and re-energising.
Reform, private capital needed to develop infrastructure in Africa

In Sub-Saharan Africa, the overwhelming need for infrastructure has motivated regional economic organizations to push for an ambitious agenda of private participation. But to begin solving Africa's infrastructure investment problems will also require broad institutional reform along with greater financial commitments by governments and donors. The private sector appears capable of supplying only a fraction of the estimated US$5-12 billion a year in additional infrastructure finance that Africa needs to meet its Millennium Development Goals for infrastructure. Meeting Africa's infrastructure development challenges will require substantial increases in government budgetary allocations and official development assistance.
Epidermal Growth Factor Receptor-GEP100-Arf6 Axis Affects the Prognosis of Lung Adenocarcinoma

The overexpression of Arf6 and GEP100 is responsible for the invasive activity that is crucial for the activation of the epidermal growth factor receptor (EGFR) signaling pathways in human cancer. However, whether or not the expression of the EGFR-GEP100-Arf6 axis can be used as a biomarker for the prognosis of lung cancer has yet to be fully determined. Tumor specimens were collected from 182 patients who underwent a complete resection for lung adenocarcinoma. We analyzed phospho-EGFR (p-EGFR), GEP100, and Arf6 expression levels in the primary tumor by immunohistochemical analysis. The expression of p-EGFR, GEP100, and Arf6 was observed in 65 (35.7%), 95 (52.2%), and 20 (11.0%) patients, respectively. Significant associations between p-EGFR and GEP100 expression and vessel invasion were identified. The expression of these individual molecules was not associated with any statistically significant differences in survival. However, triple positive expression of p-EGFR, GEP100, and Arf6 was significantly associated with an increased risk of death based on the multivariate analysis. The EGFR-GEP100-Arf6 axis affected the prognosis of patients with primary lung adenocarcinoma. The combination of p-EGFR, GEP100, and Arf6 staining can predict the prognosis of patients after surgery.
NO and asymmetrical dimethylarginine in hypertension and type 2 diabetes

1. Abstract 2. Introduction 3. Asymmetrical dimethylarginine and nitric oxide in essential hypertension 4. Salt, potassium and calcium modulate endothelial NO generation 5. Endocannabinoid signalling in NO generation and type 2 diabetes 6. Anti-hypertensive drugs suppress superoxide anion and enhance NO generation 7. L-arginine, no and asymmetrical dimethylarginine in hypertension and pre-eclampsia 8. L-arginine, asymmetrical dimethylarginine and NO in type 2 diabetes mellitus 9. Conclusions 10. Acknowledgments 11. References
Nurses knowledge, attitudes, practices and familiarity regarding disaster and emergency preparedness - Saudi Arabia

The number of reported natural and human-made disasters continues to rise worldwide. Nurses comprise the highest percent of health and medical workforce. Nurses must understand the national disaster management cycle. The present study was aimed to examine nurses' knowledge, attitudes, practices and familiarity regarding disaster and emergency preparedness-Saudi Arabia. Cross-sectional descriptive study was conducted using five tools to obtain data from 252 two registered batches of bridging nurses students. Five tools were demonstrated to collect data about demographic data, questionnaire for knowledge, attitude and practice to measure disaster preparedness and emergency preparedness information questionnaire to measure nurses' familiarity. The study findings revealed that the mean age score was 26.36±1.82 and for the knowledge level was 21.2 ± 6.0. A highly significant difference was found for attitude and practice regarding disaster preparedness as well familiarity concerned emergency preparedness P≤. 000. Based on the present study results; lacking of knowledge and practices with acceptable level of attitude regarding disaster preparedness and neutral familiarity with emergency preparedness were concluded. Thus an integration of clearly titled theory and practice teaching courses about disaster and emergency preparedness into nursing curricula are crucial needed and provided in respect to their learning/training preferences. Further, follow up research are necessary for maximizing nursing education and nursing quality in these critical areas applied to healthcare and community setting.
Comparative Advantage in Regional Agricultural of Guava

On the state of Michoacan, Mexico Guava production plays a key role among others factors because the incomes that it represents. The guava production chain generates more than two and half million in wages and an important annual gross economic benefit. However, this fruit has not been able to consolidate internationally such as Michoacan avocado. This make extremely important to know if the guava really has comparative advantage, which is the central aim of this work. An important part of the base of comparative advantage was that the production of guava presented acceptable profitability levels, so in this paper also investigated the profitability level in the guava production. In order to answer these questions the Policy Analysis Matrix (PAM) developed by Monke and Pearson (1989) was utilized. The main finding of the paper points to the existence of comparative advantage in the production of Michoacan’s guava, allowing stating resources are well used in the production of this fruit because it generates wealth. Guava production is a productive alternative, although there was some degree of vulnerability.
Diatoms Versus Copepods: Could Frustule Traits Have a Role in Avoiding Predation?

Predation is one of the strongest selection pressures phytoplankton has evolved strategies to cope with. Concurrently, phytoplankton growth must deal with resource acquisition. Experiments on mono- and mixed cultures of morphologically different diatoms exposed to copepods were performed to assess if size and shape were primary drivers in avoiding predation. Additionally, frustule silicification was investigated as a potential factor affecting prey selection by copepods. Thalassiosira pseudonana, Conticribra weissflogii, Cylindrotheca closterium, and Phaeodactylum tricornutum were exposed to the presence of Temora longicornis, a calanoid copepod. The physiological response in terms of growth, elemental composition and morphology was determined. The power of Image Flow Cytometry allowed functional single-cell analyses of mixed cultures in the presence and absence of copepods. Results highlighted that T. pseudonana although the most eaten by copepods in monospecific cultures, was not the preferred prey when the bigger C. weissflogii was added to the culture. When pennates were co-cultured with centric diatoms, their growth was unaffected by predators. Our data suggested that the frustule morphology contributes to long-term prey-predator interaction since the elongated thinner frustule, which evolved more recently, benefited cells in escaping from predators also when facing competition for resources.