Miracle-dz/UniFAR-FTUs huggingface dataset:
Modulación in Vitro de la Actividad Osteoclástica Mediada por Diferentes Dosis de Hormona Paratiroidea

Bone remodeling is a process regulated by the interaction between cells and various molecules such as parathyroid hormone (PTH). The aim of the study was to evaluate the effect of different doses of PTH on osteoclast activity in a culture mo de of bone organs. Six-day-old male C57BL/6 mice (n=14) were euthanized and the calvariae were dissected and sectioned in the middle, keeping the periosteal and endosteal. The bone fragments were divided into three groups: Group I (control without adding PTH) , Group II (addition of 3 nM PTH) and Group III (30 nM PTH), all cultured in aMEM for up to 72 h osteoclast activity was evaluated by biochemical quantification of calcium released in the culture medium at intervals of 24, 48, and 72 h and by histomorphometric analysis of bone resorption lacunae at 72 h our results show that group II exhibited significantly higher values of calcium levels in th medium compared to group I (p<0.05) in all intervals, also being higher for group III at 24 hours (p<0.05). Group II promoted a greate r demineralization area (22068 ± 2193 mm) than those found in group I (2084 ± 38 mm) and group III (8952 ± 246 mm), with statistically significant difference (p<0.001) among all groups. We concluded that in culture model of bone organs PTH promotes higher bone resorption when administered in lower doses.
High performance oxide thin film transistors with double active layers

We successfully integrated the high performance oxide thin film transistors with double active layers. The active layer is composed of IZO (or ITO) and GIZO layers. The TFT with ITO/GIZO double active layer shows a high mobility of 104 cm2/V.sec, the acceptable threshold voltage of about 0.5 V and the low Vth shift less than 1 V under voltage stress. These are very promising results for applications in driving large area AMOLED and AMLCD display.
CyTrONE: An Integrated Cybersecurity Training Framework

In a world in which cyber-attacks occur on a daily basis, cybersecurity education and training are indispensable. Current training programs rely on manual setup and configuration for hands-on activities, which is a tedious and error-prone task. In this paper we present CyTrONE, an integrated cybersecurity training framework that we designed and implemented to address such shortcomings. The key insight is automating the training content generation and environment setup tasks. The advantages of this approach are: (i) improve the accuracy of the training setup; (ii) decrease the setup time and cost; (iii) make training possible repeatedly, and for a large number of participants. In the paper we thoroughly discuss the architecture and implementation of the framework, and we evaluate it from several perspectives in order to demonstrate that CyTrONE meets the aforementioned objectives.
Expression of T‐cell Immunoglobulin‐ and Mucin‐domain‐containing Molecules‐1 and ‐3 (Tim‐1 and Tim‐3) in Helicobacter pylori Infection

Background: Th immune response plays an important role in Helicobacter pylori (H. pylori) infection. Tim‐1 and Tim‐3 are expressed on terminally differentiated Th2 and Th1 cells, respectively, and participate in the regulation of Th immune response. Until now, the role of Tim in H. pylori infection remains unclear.
Immunohistochemical analysis of pRb2/p130, VEGF, EZH2, p53, p16INK4A, p27KIP1, p21WAF1, Ki‐67 expression patterns in gastric cancer

Although the considerable progress against gastric cancer, it remains a complex lethal disease defined by peculiar histological and molecular features. The purpose of the present study was to investigate pRb2/p130, VEGF, EZH2, p53, p16INK4A, p27KIP1, p21WAF1, Ki‐67 expressions, and analyze their possible correlations with clinicopathological factors. The expression patterns were examined by immunohistochemistry in 47 patients, 27 evaluated of intestinal‐type, and 20 of diffuse‐type, with a mean follow up of 56 months and by Western blot in AGS, N87, KATO‐III, and YCC‐2, ‐3, ‐16 gastric cell lines. Overall, stomach cancer showed EZH2 correlated with high levels of p53, Ki‐67, and cytoplasmic pRb2/p130 (P < 0.05, and P < 0.01, respectively). Increased expression of EZH2 was found in the intestinal‐type and correlated with the risk of distant metastasis (P < 0.05 and P < 0.01, respectively), demonstrating that this protein may have a prognostic value in this type of cancer. Interestingly, a strong inverse correlation was observed between p27KIP1 expression levels and the risk of advanced disease and metastasis (P < 0.05), and a positive correlation between the expression levels of p21WAF1 and low‐grade (G1) gastric tumors (P < 0.05), confirming the traditionally accepted role for these tumor‐suppressor genes in gastric cancer. Finally, a direct correlation was found between the expression levels of nuclear pRb2/p130 and low‐grade (G1) gastric tumors that was statistically significant (P < 0.05). Altogether, these data may help shed some additional light on the pathogenetic mechanisms related to the two main gastric cancer histotypes and their invasive potentials. J. Cell. Physiol. 210: 183–191, 2007. © 2006 Wiley‐Liss, Inc.
IS FOREIGNNESS A SOURCE OF COMPETITIVE ADVANTAGE IN THE BRAZILIAN PHARMACEUTICAL INDUSTRY?

During the first decade of the 21st century, the accelerated growth of the pharmaceutical market in Brazil attracted investments from multinational pharmaceutical companies. National companies followed this investment trend, and the industry matured, and competition intensified. However, companies that operate in a foreign, new environment, driven by unfamiliar competitive forces encounter additional costs to operate. Using data from 2011 to 2016, this study employs panel data methodology with fixed effects using a sample of twenty-two pharmaceutical companies, eleven Brazilian subsidiaries of multinationals and eleven national companies, with the objective to investigate whether foreign companies operating in Brazil incur a liability of foreignness (LOF), which refers to these additional operating costs. This study contributes to the literature by evaluating the impact of Liability of Foreignness on working capital and profitability in the pharmaceutical sector. Our findings suggest that MNEs have a competitive disadvantage in inventory management compared to local companies.
Analisis Pemenuhan Indikator Pembayaran Kapitasi pada Fasilitas Kesehatan Tingkat Pertama di Surabaya

Lack of patient visits to FKTP causes capitation not being optimally utilized. The purpose of this research is to analyze the causes of the unfullfilled capitation payment indicators based on fulfillment of service commitment at FKTP. The type of research used is observational with cross sectional design. Approach in the research is quantitative and qualitative. The research used total sampling, where population is secondary data covering result of indicator achievement from 62 Puskesmas, 31 DPP, and 97 Klinik Pratama in Surabaya . This research concluded that indicator of AK and RPPB at FKTP still not fulfill target of safe zone. AK can be caused by the lack of participants’ knowledge of FKTP services, limited resources, and BPJS Kesehatan online application that sometimes have interruptions. FKTP needs to provide promotions and education to participants’, add resources and provide training to staff, advocate with health offices, and cooperation with other parties to help provide facilities. Whereas the target indicator of RPPB has not been achieved due to lack of socialization of Prolanic. FKTP expected to be able to run activities that are promotive and preventive in groups. Keywords: capitation, capitation payment indicators based on fulfillment of service commitment, FKTP
THE EFFECT OF FINANCIAL PERFORMANCE AND COMPANY SIZE ON SHARIA STOCK LISTED IN JAKARTA ISLAMIC INDEX

Financial performance is usually measured using a ratio that has several weaknesses that can't measure by value and need a comparison. There are new alternatives that measure performance based on value and are still rarely used specifically in stocks based on Islamic law. This study aims to find and obtain empirical evidence concerning the influence of Economic Value Added, Market Value Added, Financial Value Added and the size of the company to the stock price of sharia companies listed in the Jakarta Islamic Index period 2014-2016. By using purposive sampling, obtained sample of 13 sharia stocks observed in annual period, hence obtained panel data as much as 39. Data analyzed by using doubled linear regression. The results showed that Market Value Added has a significant positive effect on stock prices. EVA, FVA, and firm size have no significant effect on stock prices. Economic Value Added, Market Value Added, Financial Value Added and company size together have a significant effect on stock price.
Decreased sound tolerance : predisposing factors , triggers and outcomes after TRT

An analysis of 187 cases of decrease sound tolerance (DST) reveals a variety of predisposing (trigger) factors. These include exposure to loud sounds, fear about the effects of sound on the ear and the hearing, and the development of more non-specific anxieties relating to environmental threats. Diagnosis by Jastreboff category, and the relative importance and pathophysiology ofhyperacusis, misophonia and phonophobia are discussed. Following treatment in a tinnitus retraining therapy programme loudness discomfort levels reached normal levels in 44.8% by the 6 month visit, 51.4% by the 15 month visit and 60.4% by the 25th month visit . The mean number of life factors f activities affected by hyperacusis fell from 3.5 at the 1 st visit to 1.1 at the 15 month visit. Trigger factors did not affect outcome.
AXIOMATIC APPROACH APPLICATION DURING THE PRODUCT CONCEPTUAL DESIGN PHASE

Summary The field of design, be it dedicated to products, processes or organizations, has undergone and is still undergoing an intellectual renaissance - from the still prevailing notion that design can be learned only from experience, to the idea that it may be amenable to a systematic and scientific treatment. Although these design activities in different fields seem to be distinct, cognitive processes and design principles are used in all fields, thus existing many ways to approach it. The axiomatic approach is one of them, and it gives a general theoretical structure, common to all fields. In the product development process adopted, the design activity is defined as having four phases: informational, conceptual, embodiment and detailed design. Among them, the two earliest phases are detached, where the decision taken has a broaden effect on the product’s success or failure. In this sense, as an aid to the development of these two design phases, is been developed at the Group of Integrated Product Development at the Federal University of Santa Catarina (Brazil), researches aiming to determine methods and tools to aid the product development. The overall goal of this work is to study the axiomatic approach to design with emphasis on the decision-making process and to contribute to the product conceptual design informatization, registering the relations between functions and solutions. Through the identification of these relations it is intended to reduce the function-solution dependence. The greater the independence, the better the project, according to the axiomatic approach. Therefore, the research to be performed aims to determine how the axiomatic approach and its computational implementation may contribute to the product conceptual design phase.
Psychosocial Factors Associated With Adolescent Electronic Cigarette and Cigarette Use

BACKGROUND: Use of electronic cigarettes (e-cigarettes) among adolescents has increased since their introduction into the US market in 2007. Little is known about the role of e-cigarette psychosocial factors on risk of e-cigarette or cigarette use in adolescence. METHODS: Information on e-cigarette and cigarette psychosocial factors (use and attitudes about use in the home and among friends) was collected from 11th- and 12th-grade participants in the Southern California Children’s Health Study during the spring of 2014. RESULTS: Of 2084 participants, 499 (24.0%) had used an e-cigarette, including 200 (9.6%) current users (past 30 days); 390 participants (18.7%) had smoked a combustible cigarette, and 119 (5.7%) were current cigarette smokers. Cigarette and e-cigarette use were correlated. Nevertheless, 40.5% (n = 81) of current e-cigarette users had never smoked a cigarette. Psychosocial factors (home use of each product, friends’ use of and positive attitudes toward e-cigarettes and cigarettes) and participant perception of the harm of e-cigarettes were strongly positively associated both with e-cigarette and cigarette use. Most youth who reported e-cigarette use had friends who used e-cigarettes, and almost half of current users reported that they did not believe there were health risks associated with e-cigarette use. CONCLUSIONS: Longitudinal studies of adolescents are needed to determine whether the strong association of e-cigarette psychosocial factors with both e-cigarette and cigarette use will lead to increased cigarette use or dual use of cigarettes and e-cigarettes, or whether e-cigarettes will serve as a gateway to cigarette use.
Surface-Core Relationships in Human Low Density Lipoprotein as Studied by Infrared Spectroscopy (*)

The secondary structure of human apolipoprotein B at 37°C is estimated to be 24% α-helix, 23% β-sheet, 6% β-turns, 24% unordered structure, and 24% “β-strands,” characterized by a band around 1618 cm, and consistent with extended string-like chains in contact with the lipid moiety not forming β-sheets. When cooled to a temperature below the cholesteryl ester transition at 30°C, the ordering of the low density lipoprotein core results in reversible changes in the protein conformation, decreasing the apparent amount of α-helix, β-strand, and unordered structure below 30°C and increasing β-sheet and β-turns. Lowering the ionic strength affects the core-associated transitions, shifting their temperature from 30 to 20°C, and modifying protein conformation below the transition. An additional thermal event is observed at 75°C, leading to irreversible protein denaturation. In the broad temperature range between the 30 and 75°C transitions, apolipoprotein B is stable toward both temperature and ionic strength changes. After thermal denaturation, the protein retains a certain degree of ordered structure.
A SPECTROSCOPIC SEARCH FOR LEAKING LYMAN CONTINUUM AT z ∼ 0.7

We present the results of rest-frame, UV slitless spectroscopic observations of a sample of 32 z ∼ 0.7 Lyman break galaxy (LBG) analogs in the COSMOS field. The spectroscopic search was performed with the Solar Blind Channel on the Hubble Space Telescope. We report the detection of leaking Lyman continuum (LyC) radiation from an active galactic nucleus–starburst composite. While we find no direct detections of LyC emission in the remainder of our sample, we achieve individual lower limits (3σ) of the observed non-ionizing UV-to-LyC flux density ratios, fν (1500 Å)/fν(830 Å) of 20 to 204 (median of 73.5) and 378.7 for the stack. Assuming an intrinsic Lyman break of 3.4 and an intergalactic medium transmission of LyC photons along the line of sight to the galaxy of 85%, we report an upper limit for the relative escape fraction in individual galaxies of 0.02–0.19 and a stacked 3σ upper limit of 0.01. We find no indication of a relative escape fraction near unity as seen in some LBGs at z ∼ 3. Our UV spectra achieve the deepest limits to date at any redshift for the escape fraction in individual sources. The contrast between these z ∼ 0.7 low escape fraction LBG analogs with z ∼ 3 LBGs suggests that either the processes conducive to high fesc are not being selected for in the z ≲ 1 samples or the average escape fraction is decreasing from z ∼ 3 to z ∼ 1. We discuss possible mechanisms that could affect the escape of LyC photons.
Serogroup C meningococcal outbreaks in the United States. An emerging threat.

OBJECTIVE Multiple outbreaks of serogroup C Neisseria meningitidis have recently been reported from diverse areas of the United States. To better define the characteristics of this increasingly important problem, we reviewed data on all known serogroup C outbreaks in the United States from January 1980 through June 1993. DATA SOURCES MEDLINE searches, Centers for Disease Control and Prevention records, state health department officials, infectious disease experts, and the meningococcal vaccine manufacturer. DEFINITION OF AN OUTBREAK: Three or more cases of serogroup C meningococcal disease within a 3-month period, either among members of a community or persons attending a single school or other institution, for which those cases represented an attack rate of at least five per 100,000 population. RESULTS Twenty-one outbreaks of serogroup C meningococcal disease were identified; eight occurred since 1991. In 1992 and the first half of 1993, approximately 180,000 doses of vaccine were administered for outbreak control, compared with approximately 34,000 doses from 1980 to 1991. Approximately 50% of community-outbreak cases were between the ages of 5 and 24 years, compared with only 19% of sporadic serogroup C cases (P < .001). Subtyping of patient isolates indicates that outbreaks are clonal; however, at least five distinct but closely related strains have caused recent outbreaks. CONCLUSIONS Serogroup C outbreaks are occurring more frequently in the United States. The effectiveness of preventive measures depends on early recognition; therefore, physicians should promptly report all cases of suspected meningococcal disease, and the causative serogroup should be established for every case.
Forest harvesting impacts on the peak flow regime in the Columbia Mountains of southeastern British Columbia: An investigation using long‐term numerical modeling

Numerical hydrologic simulation, in combination with synthetic weather generation, was used to assess the sensitivity of the peak flow regime for hourly, daily, and 7‐day discharge to hypothetical harvesting scenarios in Redfish Creek in southern British Columbia. Simulation was based on stationary vegetation cover, thus representing potential peak flow regime adjustments during the first few critical years following harvesting. The relative difference between preharvest and postharvest peak discharge quantiles (ΔQT), estimated by comparing GEV distributions fit to the simulated preharvest and postharvest annual maximum series, tended to increase with increasing harvest area; however, the relationship was strongly influenced by the elevation distribution of harvest blocks. Although rainfall was determined to be a factor in roughly three quarters of all peak discharge events, the flood frequency of Redfish Creek is fundamentally a function of the frequency structure of snowmelt runoff. Consequently, changes in runoff synchronization between various elevation bands largely drove the magnitude of ΔQT, and the degree of increased synchronization was found to be greatest following harvesting above H60 (elevation above which lies 60% of basin area) and least following harvesting below H60. As a result, only harvesting schemes that incorporated cut blocks above H60 tended to generate significant (α = 0.05) ΔQT for a wide range of return periods (T), regardless of discharge timescale. Significant ΔQT ranged from 6 to 14% for hourly, 5 to 14% for daily, and 5 to 20% for 7‐day discharge in the range of 1.25 ≤ T ≤ 100 years. For a given scenario, hourly and daily ΔQT showed little variation with T, suggesting that small and large discharge events responded similarly to forest harvesting. However, this apparent trend substantially overstates ΔQT for the largest hourly and daily peak discharge events such that the relationship of ΔQT to T is inconclusive for T > 30 years. For 7‐day discharge, ΔQT increases with increasing T for 1.25 ≤ T ≤ 100 years.
Human γδ T Lymphocytes Are Licensed for Professional Antigen Presentation by Interaction with Opsonized Target Cells

Activated human blood γδ T cells have also been previously demonstrated to behave as professional APCs, although the processes that control APC function have not been characterized. n this study, we show that the acquisition of potent APC function by human blood γδ T cells is achieved after physical interaction with an Ab-coated target cell, a process that we refer to as licensing. In cancer models, licensing of γδ T cells by tumor-reactive mAbs promotes the uptake of tumor Ags and professional presentation to tumor-reactive αβ T cells. We propose that licensing by Ab is a mechanism whereby the adaptive properties of γδ T cells are induced by their innate functions in a spatially and temporally controlled manner.
Perception of Smallholder Farmers towards the Kilimo Plus Subsidy Program in Nakuru North District, Kenya

The perception of farmers towards a technology influences the farmer’s uptake of that technology. This study examines the perception of smallholder farmers towards a fertilizer and certified seed subsidy program. Data from fifty two respondents was collected using a structured questionnaire and analysed using summation, median and mode. Results showed that the farmers perceived the subsidy program positively. The study recommends a further study on the factors that influenced the perception.
The κ-μ Extreme Distribution

A number of realistic wireless applications can be found for which the propagated signal may experience extreme fading conditions. In particular, a recent work has reported on an experiment conducted within an enclosed environment where it has been shown that the fading conditions are indeed harsh, drastically departing from those predicted by traditional fading models. This paper investigates the κ-μ Extreme fading distribution, a member of the κ-μ fading model and obtained from it when its parameters reach their extreme values (κ → ∞ and μ → 0) for a fixed amount of fading. Field data reported elsewhere and collected in enclosed environment, along with other fading data collected by the authors' team, are used to compare the curve fit performance of the κ-μ Extreme model and the recently proposed Two-Ray distribution. The results show that the κ-μ Extreme distribution is flexible and suitable to model these scenarios. The performance of this new model is then explored in the three basic combining techniques, namely selection, maximum ratio, and equal gain, and a number of exact, closed-form formulas are obtained. Interestingly, it is shown that in extreme fading conditions, the selection combiner may outperform the equal gain combiner.
Cellular localization and distribution of glucocorticoid receptor immunoreactivity and the expression of glucocorticoid receptor messenger RNA in rat pituitary gland A combined double immunohistochemistry study and in situ hybridization histochemical analysis

By means of double immunohistochemical techniques and a nonradioisotopic in situ hybridization method, we determined the colocalization pattern of glucocorticoid receptor (GR) and pituitary hormones and the GR messenger RNA (mRNA) expression in the pituitaries of Wistar adult male rats. Immunoreactivity for GR was detected in the nuclei of cells in the anterior and posterior pituitary. Double immunohistochemistry revealed that the colocalization of GR and anterior pituitary hormones occurred in almost 99% of the growth hormone (GH)-producing cells and adrenocorticotropic hormone (ACTH)-producing cells, and in 67% of the thyroid stimulating hormone (TSH)-producing cells. Almost all of the folliculostellate cells (93%), marginal layer cells (94%) in the anterior pituitary, and pituicytes (96%) in the posterior pituitary immunostained for S100 protein antibody were also immunostained with GR. GR mRNA was abundant in the cytoplasm of anterior and intermediate pituitary cells but scattered sparsely in that of the posterior pituitary. These results suggest that glucocorticoids directly influence certain pituitary cells in order to regulate cell function, including the synthesis and/or secretion of hormones.