Miracle-dz/UniFAR-FTUs huggingface dataset:
Ontogenetic and Temporal Variations in Herbivory and Defense of Handroanthus spongiosus (Bignoniaceae) in a Brazilian Tropical Dry Forest

ABSTRACT We compared the richness and abundance of free-feeding herbivore insects (sap-sucking and leaf-chewing), leaf herbivory damage, leaf toughness and total phenolic content between two ontogenetic stages (juvenile and reproductive) of Handroanthus spongiosus (Rizzini) S. O. Grose (Bignoniaceae) throughout the rainy season in a Brazilian seasonally dry tropical forest. Twenty marked individuals of H. spongiosus were sampled per ontogenetic stage in each period of the rainy season (beginning, middle, and end). Herbivore richness and abundance did not differ between ontogenetic stages, but higher percentage of leaf damage, higher concentration of phenolic compounds, and lower leaf toughness were observed for juvenile individuals. The greatest morphospecies abundance was found at the beginning of the rainy season, but folivory increment was higher at the end, despite the fact that leaf toughness and total phenolic content increased in the same period. No significant relationships between leaf damage and both total phenolic content and leaf toughness were observed. These results suggest that insect richness and abundance do not track changes in foliage quality throughout plant ontogeny, but their decrease along rainy season confirms what was predicted for tropical dry forests. The general trends described in the current study corroborate those described in the literature about herbivores and plant ontogeny. However, the lack of relationship between herbivore damage and the two plant attributes considered here indicates that the analyses of multiple defensive traits (the defense syndrome) must be more enlightening to determine the mechanisms driving temporal and spatial patterns of herbivore attack.
Brucella suis infection in domestic pigs in Sardinia (Italy)

SUMMARY During a 4-year (2007–2010) survey, the presence of Brucella suis infection in domestic pigs in Sardinia was investigated. Serum samples were collected from breeding pigs located on 108 commercial farms with documented reproductive problems and analysed using the Rose Bengal (RBT) and complement fixation (CFT) tests for screening and confirmation of Brucella, respectively. Of the 1251 serum samples analysed by RBT, 406 sera, originating from 36 farms, were positive for B. suis. CFT was positive in 292/748 sera analysed, confirming positivity in all 36 pig herds. Pigs with international complement fixation test units per ml (ICFTU/ml) values ⩾160 were slaughtered, and their organs collected for bacteriological examination and testing by polymerase chain reaction (PCR). Brucella spp. strains were isolated in culture from 13/502 organs analysed, and subsequently identified as B. suis biovar 2. PCR detected positivity to Brucella spp. in 19/285 organs analysed. These results confirm the presence and emergence of B. suis infection in domestic pigs in Sardinia.
Are hearing aid owners able to identify and self-report handling difficulties? A pilot study

Abstract Objective: Although clinician administered surveys evaluating hearing aid handling skills exist, the development of a self-administered version may reduce clinical load, save consultation time, and facilitate more frequent use than face-to-face consultations allow. However, there is currently no evidence to support whether hearing aid owners can accurately self-report hearing aid handling skills via self-report survey that systematically evaluates the ability to accurately perform the individual aspects of hearing aid handling required for effective hearing aid management. Design: An explorative pilot study using a prospective research design. Study sample: Nineteen adult hearing aid owners, aged between 65 and 93 years. Results: The self-administered survey demonstrated high sensitivity when compared with clinician evaluation of skills, with 93% of participants accurately self-identifying and reporting whether hearing aid handling skill training was required. Conclusions: Hearing aid owners are able to accurately self-report hearing aid handling difficulties when provided with an itemised list of skills.
Antithrombotic Drugs in the Primary Medical Management of Intermittent Claudication: A Meta-analysis

Summary Background. There is no consensus on the efficacy of the antithrombotic drugs available for patients with intermittent claudication. Methods. A Medline and manual search was used to identify relevant publications. Uncontrolled or retrospective studies, double reports or trials without clinical outcomes were excluded. Included studies were graded as level 1 (randomised and double- or assessor-blind), level 2 (open randomised), or level 3 (non-randomised comparative). Mortality, cerebro- or cardiovascular events, amputations, arterial occlusions or number of revascularization procedures performed in the lower limbs, pain-free and total walking distance, ankle brachial index and calf blood flow, were the main outcomes considered. When feasible, end of treatment results, either continuous or binary, were combined with appropriate statistical methods. Results. Mortality was significantly decreased by ticlopidine compared to placebo (common odds ratio 0.68, 95% C.I., 0.49 - 0.95); clopidogrel decreased vascular events in comparison to aspirin (odds ratio 0.76, 95% C.I., 0.63 - 0.92) in level 1 studies. Arterial occlusions and the number of revascularization procedures performed were statistically significantly decreased by aspirin and ticlopidine, respectively. A small but statistically significant improvement in pain-free walking distance was determined by picotamide, indobufen, low molecular weight heparins, sulodexide and defibrotide, in small studies. Conclusions. Clopidogrel and ticlopidine do reduce clinically important events in patients with intermittent claudication and could be added to the primary medical treatment of these patients. The use of aspirin in these patients cannot be based on direct evidence, but only on analogy with coronary and cerebral atherosclerosis, where it has documented efficacy. Other antithrombotic drugs were not properly evaluated in patients with intermittent claudication.
Interleukin-6 response of epithelial cell lines to bacterial stimulation in vitro

This study demonstrated that epithelial cell lines secrete interleukin-6 (IL-6) in response to stimulation with gram-negative bacteria. Human epithelial cell lines of urinary tract origin (A-498 and J82) and of intestinal origin (HT-29 and Caco-2) were analyzed for the secretion of IL-6 by using the B9 bioassay. The supernatants from cells maintained with culture medium were used to assess the constitutive production of IL-6. The supernatants from cells exposed to Escherichia coli strains, lipopolysaccharide, lipid A, and isolated fimbriae were used to quantitate the IL-6 response to these stimulants. The urinary tract epithelial cell lines were found to constitutively secrete IL-6. The IL-6 activity in the supernatants of the bladder cell line (J82) increased above constitutive levels after 2 h of stimulation by most of the bacterial strains tested. The IL-6 activity in the supernatants of the kidney line (A-498) accumulated at a constant rate over the 24-h assay period. The role of bacterial adherence for the induction of IL-6 production was investigated by comparing the responses to recombinant E. coli strains expressing different fimbriae. In addition, isolated P and S fimbriae with and without the receptor binding domain were also used as stimulants. The IL-6 activity in the supernatants of the bladder cell line increased after exposure to bacteria and bacterial products regardless of their adhesive properties. In contrast, the kidney cell line was stimulated to secrete significantly more IL-6 by adhering bacteria and by adhesin-positive P fimbriae than by nonadhering bacteria or adhesin-negative P fimbriae. The S-fimbrial preparations had no specific effects on the IL-6 activity of the cell supernatants. These results are consistent with our hypothesis that epithelial cells can be a major source of IL-6 when stimulated by bacteria and that the adhesive properties of the bacteria can influence this response.
Breaking the boundary: A droop and master-slave hybrid control strategy for parallel inverters in islanded microgrids

The well-known droop control and master-slave control methods are two dominant coordinative control schemes for inverter interfacing parallel distributed energy resources (DERs) in islanded AC microgrids. However, both these two control methods have some drawbacks and inherent limitations in practical application. After analyzing their complementary strengths and weaknesses, this paper proposed a hybrid control strategy, which exploits advantages from both droop control and master-slave control methods. Firstly, the system configuration and control architecture are introduced. Then the control loop design and operation principles are discussed. Comparing to traditional methods, this proposed hybrid control strategy provides better flexibility, stronger reliability, ideal power sharing and voltage regulating performance. Finally, simulation results are presented to validate the advantages of this proposed strategy.
THE CONFLICT BETWEEN TEACHERS' BELIEFS AND CLASSROOM PRACTICES

The relationships between the beliefs and practices of mathematics teachers'have been shown to be complex. In this case study of one mathematics teacher, it was found that while the teacher had clear and quite strongly held beliefs about mathematics and its teaching and learning, his classroom practices did not always reflect these beliefs. In some lessons other . factors meant that the lessons was not conducted in a way which reflected the teacher's beliefs. However, the teacher was aware of this contradiction. Many factors influence the classroom practices of mathematics teachers. Thompson (1992) noted that not only do teachers' beliefs about mathematics and its teaching and learning appear to have a significant effect on their approaches to teaching, but also that the relationship between beliefs and practice is complex. Studies have demonstrated "varying degrees of consistency between teacher's professed beliefs about the nature of mathematics and the teachers' instructional practices" (Thompson, 1992, p. 134). The aim of this case study was to explore the relationships among beliefs, context and the mathematics teaching practices of one year 8 mathematics teacher. The case study was part of a larger study into the use of writing activities in mathematics classrooms.
Open Earmold Fittings for Improving Aided Auditory Localization for Sensorineural Hearing Losses with Good High‐Frequency Hearing

Objective: We tested the hypothesis that the use of nonoccluding earmolds for hearing aid fittings could optimize auditory localization in the vertical plane for people with moderate, low‐frequency hearing losses and good hearing at frequencies above 4000 Hz. This benefit was expected to arise from leaving the pinna unobstructed and by optimizing hearing (unaided) for frequencies above the hearing aid's limit. Design: Twenty‐two participants had hearing losses greater than 30 dB over the range 250 to 2000 Hz and had minimal losses (<30 dB) at 6000 Hz and 8000 Hz. Their auditory localization was tested, using a horizontal arc and a vertical arc of loud‐speakers, when listening unaided and when fitted bilaterally with Behind The Ear hearing aids with three earmold types‐closed(occluded), open (partly occluded), sleeve (nonoccluded). Results: Localization of vertical plane sound sources was significantly poorer for the closed earmold condition than for unaided. The open and sleeve conditions were better than the closed condition, and, for the sleeve earmold, vertical localization was almost equal to that unaided. The capacity to benefit from using open rather than closed earmolds was related to hearing level; people with the best hearing at 4000, 6000, and 8000 Hz received the most benefit. There was limited evidence that open earmolds also can be advantageous for some aspects of horizontal plane localization. Conclusions: Nonoccluding earmolds optimize aided vertical localization for hearing aid users with good high‐frequency hearing. The "sleeve" earmold, so far used only in research, may be a useful clinical option.
Costimulation Requirements for Antiviral CD8+ T Cells Differ for Acute and Persistent Phases of Polyoma Virus Infection1

The requirement for costimulation in antiviral CD8+ T cell responses has been actively investigated for acutely resolved viral infections, but it is less defined for CD8+ T cell responses to persistent virus infection. Using mouse polyoma virus (PyV) as a model of low-level persistent virus infection, we asked whether blockade of the CD40 ligand (CD40L) and CD28 costimulatory pathways impacts the magnitude and function of the PyV-specific CD8+ T response, as well as the humoral response and viral control during acute and persistent phases of infection. Costimulation blockade or gene knockout of either CD28 or CD40L substantially dampened the magnitude of the acute CD8+ T cell response; simultaneous CD28 and CD40L blockade severely depressed the acute T cell response, altered the cell surface phenotype of PyV-specific CD8+ T cells, decreased PyV VP1-specific serum IgG titers, and resulted in an increase in viral DNA levels in multiple organs. CD28 and CD40L costimulation blockade during acute infection also diminished the memory PyV-specific CD8+ T cell response and serum IgG titer, but control of viral persistence varied between mouse strains and among organs. Interestingly, we found that CD28 and CD40L costimulation is dispensable for generating and/or maintaining PyV-specific CD8+ T cells during persistent infection; however, blockade of CD27 and CD28 costimulation in persistently infected mice caused a reduction in PyV-specific CD8+ T cells. Taken together, these data indicate that CD8+ T cells primed within the distinct microenvironments of acute vs persistent virus infection differ in their costimulation requirements.
Seasons of Stress: Understanding the Dynamic Nature of People’s Ability to Respond to Change and Surprise

AbstractClimate change is impacting coastal communities in rural Alaska in multiple direct and indirect ways. Here, findings are reported from ethnographic research done with municipal workers, community leaders, and other local experts in the Bristol Bay region of Alaska, where it is found that climate change is interacting with local social and environmental circumstances in ways more nuanced than are generally captured by frameworks for vulnerability analysis. Specifically, the research herein shows the importance of the temporal dimension of vulnerability to environmental change in rural Alaska, both in terms of temporal patterns that emerge from climate-driven stressors and also with respect to how, and under what conditions, people in rural communities may design or manage effective responses to change. There are multiple factors that play into how rural communities will be affected by some climatic or environmental stress; ultimately, the impacts of climatic and environmental stressors will differ .
Increased nuclear factor kappa B activation in critically ill patients who die.

OBJECTIVES To determine nuclear factor kappa B (NF-kappa B) activation in mononuclear and neutrophils from critically ill patients and to compare NF-kappa B activation with circulating concentrations of interleukin (IL)-6, IL-8, and soluble intercellular adhesion molecule (sICAM)-1. DESIGN Observational study. SETTING University Teaching Hospital, eight-bed intensive care unit in northeast Scotland. PATIENTS Ten patients admitted to the intensive care unit who fulfilled the criteria for systemic inflammatory response syndrome were studied at 0, 24, 48, and 72 hrs. Six healthy volunteers were also studied. INTERVENTIONS None. MEASUREMENTS AND MAIN RESULTS NF-kappa B activation was significantly higher in patients compared to healthy volunteers in both neutrophils (p = .001) and mononuclear leukocytes (p = .013). In the six patients who survived to 96 hrs, the level of NF-kappa B activation in mononuclear cells remained constant (p = .9). However, in the four patients who died before 96 hrs, mononuclear cell NF-kappa B activation increased markedly and was significantly higher before death than in those who survived to 96 hrs (p = .0105). NF-kappa B activation in neutrophils similarly remained constant in patients who survived to 96 hrs (p = .4) but did not show the same increase before death. Circulating concentrations of IL-6, IL-8, and sICAM-1 were elevated but were unrelated to leukocyte NF-kappa B activation. CONCLUSIONS We found NF-kappa B activation in mononuclear and neutrophils in patients with systemic inflammatory response syndrome, which increased markedly before death in mononuclear leukocytes and was not related to plasma IL-6, IL-8, and sICAM-1 concentrations. These data support the need for further study of the role of NF-kappa B activation in mortality from systemic inflammatory response syndrome and sepsis.
Affective disorders in five United States communities

Synopsis Results on the age/sex specific prevalence of DSM-III affective disorders from the NIMH Epidemiologic Catchment Area Study (ECA), a probability sample of over 18000 adults from five United States communities, are presented. The cross-site means for bipolar disorder ranged from 0·7/100 (2 weeks) to 1–2/100 (lifetime), with a mean age of onset of 21 years and no sex difference in rates. The cross-site means for major depression ranged from 1·5/100 (2 weeks) to 4·4/ 100 (lifetime), with a mean age of onset of 27 years and higher rates in women. The cross-site means for dysthymia, a chronic condition, was 3·1/100 with a higher rate in women. There was reasonable consistency in prevalence rates among sites. The implications of these findings for understanding psychopathology are discussed.
The Role of New Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia

AbstractImatinib mesylate was the first tyrosine kinase inhibitor (TKI) approved for the management of chronic myeloid leukemia. Imatinib produces acceptable responses in approximately 60% of patients, with approximately 20% discontinuing therapy because of intolerance and approximately 20% developing drug resistance. The advent of newer TKIs, such as nilotinib, dasatinib, bosutinib, and ponatinib, has provided multiple options for patients. These agents are more potent, have unique adverse effect profiles, and are more likely to achieve relevant milestones, such as early molecular responses (3–6 months) and optimal molecular responses (12 months). The acquisition of BCR-ABL kinase domain mutations is also reportedly lower with these drugs. Thus far, none of the randomized phase III clinical trials have shown a clinically significant survival difference between frontline imatinib versus newer TKIs. Cost and safety issues with the newer TKIs, such as vascular disease with nilotinib and ponatinib and pulmonary hypertension with dasatinib, have dampened the enthusiasm of using these drugs as frontline options. While the utility of new TKIs in the setting of imatinib failure or intolerance is clear, their use as frontline agents should factor in the age of the patient, additional comorbidities, risk stratification (Sokal score), and cost. Combination therapies and newer agents with potential to eradicate quiescent chronic myeloid leukemia stem cells offers future hope.
Carnitine partially protects the rat testis against the late damage produced by doxorubicin administered during pre‐puberty

Doxorubicin, an anticancer drug, is widely included in chemotherapy protocols to combat childhood cancer. Carnitine, an important quaternary amine, is present in testis and epididymis and is involved in sperm maturation; it has been used in infertility treatment. In a previous study, our group observed that l‐carnitine given before etoposide, another chemotherapeutic drug, reduces the spermatogenic damage and protects germ cells against apoptosis. This study aimed to evaluate the antiapoptotic and cytoprotective actions of l‐carnitine in long‐ and mid‐term basis, on the seminiferous epithelium of doxorubicin‐treated pre‐pubertal rats. Forty‐eight 30‐day‐old male Wistar rats were distributed into four groups: sham‐control; doxorubicin; carnitine; carnitine/doxorubicin (l‐carnitine injected 1 h before doxorubicin). The rats were submitted to euthanasia at 64 and 100 days of age and their testes were collected for biometric, morphometric, and histopathological analyses. The numerical density of apoptotic germ cells was obtained (TUNEL method). In adult phase (100 days), the following spermatic parameters were analyzed: mature spermatid (19 step) count and sperm daily production per testis; sperm number and transit time through the epididymal caput/corpus and cauda; frequency of morphologically abnormal spermatozoa (from epididymal fluid), as well as sperm DNA integrity (Comet assay). The testicular and spermatic parameters at both ages were improved in rats treated with carnitine before doxorubicin. At 64 days, the TUNEL‐positive germ cell frequency was lower in the carnitine/doxorubicin‐treated rats comparatively to the doxorubicin‐treated rats. At 100 days of age, the sperm DNA fragmentation was also lower in the previously carnitine‐treated rats, as evidenced by the analysis of three parameters. Carnitine reduced the late testicular and spermatic damages caused by doxorubicin, probably providing a partial cytoprotection against the deleterious action of doxorubicin administration to pre‐pubertal rats. However, further studies shall be undertaken to investigate the protective mechanisms involved in such germ cell preservation.
Do Labor Unions Always Lead to Underinvestment

ABSTRACT We examine the relation between labor union strength and investment efficiency using the comprehensive firm-level data of Korean-listed companies. We find that the perceived underinvestment related to unionization documented in previous studies is attributable to a negative relation between union strength and investment in overinvesting firms. In fact, union strength is positively related to the level of investment in underinvesting firms. We further find that the relation between union strength and investment efficiency is more pronounced for chaebol firms where inefficient investments are more likely due to greater agency problems between the controlling and minority shareholders. Finally, we document that the investment has more positive value implications in firms with a stronger union. Our results suggest that unions play an important role as a nonfinancial stakeholder in curbing inefficient investments. JEL Classifications: G30; G31; J53; J54; M41; M54.