Miracle-dz/UniFAR-FTUs huggingface dataset:
A case study of os cuneiforme mediale bipartum from Sigtuna, Sweden

At the end of the 10th century the first Swedish town Sigtuna was founded, which can be recognized as the beginning of urbanization in the Malaren valley. Christianity was growing strong and the administrative power was probably concentrated to a few magnates gathered around a king. Though, Sigtuna played an important religious and political role, the time of prosperity was short and at the end of the 13th-early 14th century the importance of the town declined. The ambition with the present thesis has been to investigate the demography of the human skeletal material excavated in Sigtuna during the period 1983-1999. The skeletons from 528 individuals from six cemeteries dated to the end of 10th century to the early 16th century have been analysed. The material was subdivided into three chronological development phases synonymous with the establishment, the peak of prosperity and the decline of the town. Well-recognized anthropological techniques were applied together with a health index and chemical tests such as stable isotopes and trace elements. The main aims were to investigate: 1) differences in the material between contemporary inhabitants in Sigtuna, 2) differences in the material between the different chronological phases, 3) differences between the osteological results achieved from Sigtuna and results from other skeletal materials and 4) if the results can be connected to the indications of urbanization. The results showed that:- Some differences between contemporary cemeteries are discernable. Variations in stable isotopes suggest dietary differences between the women at different cemeteries. Furthermore, differences in age- and sex distribution, and mean stature are discernable between some of the contemporary samples and even within a cemetery. The discrepancies may be related to prevailing social structures in Sigtuna. - A decline in health through time is demonstrated. The negative trend is particularly marked for women. In addition demographic changes suggest an increased migration of adults to Sigtuna. The health deterioration may be connected to e.g. increased population density and an increased risk of infections. - In comparison with other materials the anthropological results, including the health index, suggests that the inhabitants in Sigtuna showed an urban pattern and that the quality of life, at least in the initial phase, was relatively good. - The sex distribution shows a generally male dominance possibly caused by selective excavations except at the oldest site without an adherent church. The uneven sex distribution may, alternatively, be a result of the urban character of Sigtuna i.e. a Christian and political administrative centre.The osteological results are in line with the archaeological and historical data. It is suggested that the consequences of urbanization such as immigration, deterioration of health and social ranking, implied by several osteological parameters and the chemical analysis, acted differently through the gender lines.
Dimensions of Brand Equity in the Chain Restaurant Industry

Four of the dimensions that combine to contribute to chain restaurants’ brand equity are brand awareness, brand image, perceived quality, and brand loyalty. A test of a structural model connecting these four attributes of brand equity was based on data collected from 188 patrons of five chain restaurant brands in Korea. The resulting data analysis demonstrates that the four dimensions of brand equity are interrelated. The model indicates that the foundation of brand equity is brand awareness. However, while brand awareness influences brand loyalty formation, its impact is mediated by the effects of brand image and perceived quality. In addition, although brand awareness is a prerequisite of brand loyalty, brand image and perceived quality bear a stronger impact on the development of brand loyalty. On balance, the implications of these findings support the restaurant industry’s practices of constant promotion, quality assurance, and process improvement.
Housing Choice and Relative Tenure Prices

Increasing attention has been focused, as of late, on the relatively low rate of rental housing starts and the increase in apartment conversions to condominium ownership. By some estimates, additions to owner–occupied housing stock since 1970 have occurred at twice the rate of addition to the rental stock, a pattern that has caused concern to some policymakers.
IMPORTANCE‐PERFORMANCE ANALYSIS OF CITIZEN SATISFACTION SURVEYS

This paper introduces the method of importance-performance analysis of citizen surveys, a useful approach to understanding citizen satisfaction with local government services. Using data from a US national online panel, we directly compare two approaches to importance-performance analysis: one employing an explicitly stated measure of importance, the other using a measure of importance derived from regression analysis. The different results that the two approaches give suggest that local government administrators and policy analysts arrive at distinctly different conclusions depending on which importance measure they use. These differences are illustrated by simulating the change in citizen satisfaction that would result from improvement in the top-rated services according to each measure. Research and policy implications are discussed.
The GTPase-activating protein n-chimaerin cooperates with Rac1 and Cdc42Hs to induce the formation of lamellipodia and filopodia

n-Chimaerin is a GTPase-activating protein (GAP) mainly for Rac1 and less so for Cdc42Hs in vitro. The GAP activity of n-chimaerin is regulated by phospholipids and phorbol esters. Microinjection of Rac1 and Cdc42Hs into mammalian cells induces formation of the actin-based structures lamellipodia and filopodia, respectively, with the former being prevented by coinjection of the chimaerin GAP domain. Strikingly, microinjection of the full-length n-chimaerin into fibroblasts and neuroblastoma cells induces the simultaneous formation of lamellipodia and filopodia. These structures undergo cycles of dissolution and formation, resembling natural morphological events occurring at the leading edge of fibroblasts and neuronal growth cones. The effects of n-chimaerin on formation of lamellipodia and filopodia were inhibited by dominant negative Rac1(T17N) and Cdc42Hs(T17N), respectively. n-Chimaerin's effects were also inhibited by coinjection with Rho GDP dissociation inhibitor or by treatment with phorbol ester. A mutant n-chimaerin with no GAP activity and impaired p21 binding was ineffective in inducing morphological changes, while a mutant lacking GAP activity alone was effective. Microinjected n-chimaerin colocalized in situ with F-actin. Taken together, these results suggest that n-chimaerin acts synergistically with Rac1 and Cdc42Hs to induce actin-based morphological changes and that this action involves Rac1 and Cdc42Hs binding but not GAP activity. Thus, GAPs may have morphological functions in addition to downregulation of GTPases.
Dynamic Pricing, Production, and Channel Coordination with Stochastic Learning

We consider a decentralized two‐period supply chain in which a manufacturer produces a product with benefits of cost learning, and sells it through a retailer facing a price‐dependent demand. The manufacturer's second‐period production cost declines linearly in the first‐period production, but with a random learning rate. The manufacturer may or may not have the inventory carryover option. We formulate the resulting problems as two‐period Stackelberg games and obtain their feedback equilibrium solutions explicitly. We then examine the impact of mean learning rate and learning rate variability on the pricing strategies of the channel members, on the manufacturer's production decisions, and on the retailer's procurement decisions. We show that as the mean learning rate or the learning rate variability increases, the traditional double marginalization problem becomes more severe, leading to greater efficiency loss in the channel. We obtain revenue sharing contracts that can coordinate the dynamic supply chain. In particular, when the manufacturer may hold inventory, we identify two major drivers for inventory carryover: market growth and learning rate variability. Finally, we demonstrate the robustness of our results by examining a model in which cost learning takes place continuously.
Collaboration or Paradigm Shift?: Caveat Emptor and the Risk of Romance with Economic Models for Strategy and Policy Research

While the “formulation” or “strategy” side of business policy has always drawn appropriately from economic theory, we caution that, taken to its logical extreme, economic theory ignores the importance of implementation, implies lack of choice in organization decision-making, and makes the organization a nonentity. In this paper, we outline the fundamental differences between behavioral and economic approaches to business policy. These differences are highlighted by an illustration of their divergent perspectives on corporate “agency”.
Effect of wind on stock market returns: evidence from European markets

Environmental psychology studies have found evidence that wind speed has a strong influence on mood and comfort. This study investigated the relationship between wind speed and daily stock market returns across 18 European countries from 1994 to 2004. A significant and pervasive wind effect was found on stock returns. This finding was supported by psychological literature claiming that mood affects judgement and decision-making in situations involving uncertainty and risk, and coincides with the argument of misattribution. This investigation also found strong seasonality effect and temperature effect in European stock markets. Specifically, the influence of wind on stock returns is demonstrated to be more significant than that of sunlight, indicating that wind might exert a stronger impact on mood than sunshine and hence be a better proxy for mood than sunshine. Above all, our findings contradict the rational asset-pricing hypothesis and contribute to the behavioural finance literature.
Crisis in Amplitude Control Hides in Multistability

A crisis of amplitude control can occur when a system is multistable. This paper proposes a new chaotic system with a line of equilibria to demonstrate the threat to amplitude control from multistability. The new symmetric system has two coefficients for amplitude control, one of which is a partial amplitude controller, while the other is a total amplitude controller that simultaneously controls the frequency. The amplitude parameter rescales the basins of attraction and triggers a state switch among different states resulting in a failure of amplitude control to the desired state.
Rapamycin‐Induced Hypophosphatemia and Insulin Resistance Are Associated With mTORC2 Activation and Klotho Expression

Rapamycin, an immunosuppressive drug used to prevent rejection after kidney transplantation, influences phosphate homeostasis, induces insulin resistance and has been shown to prolong lifespan in animal models. Because Klotho is an aging‐suppressor gene controlling phosphate metabolism and insulin sensitivity, we investigated the influence of rapamycin on Klotho expression. A total of 100 kidney transplant recipients, 50 chronically treated with rapamycin and 50 with calcineurin inhibitors, were enrolled; 20 healthy subjects were employed as control. In the rapamycin group, serum phosphate was lower than in the CNI group with an increase in phosphate excretion and a reduction in its reabsorption. In addition, rapamycin increased insulin resistance as shown by HOMA index. Rapamycin treatment of an immortalized proximal tubular cell line induced the expression of Klotho, the phosphorylation of AKT in Ser473, downstream target of mTORC2 and the expression of RICTOR, mTORC2 main component. AKT inhibition reduced the rapamycin‐induced expression of Klotho. In vivo rapamycin treatment induced higher degree of RICTOR and AKT Ser473 expression directly correlating with long‐term rapamycin exposure, FEPO4 and HOMA index. In conclusion, our data would suggest that rapamycin may influence phosphate homeostasis and insulin resistance modulating Klotho expression through mTORC2 activation.
Successfully increasing technological control through minimizing workplace resistance: understanding the willingness to telework

Technological change has permitted organizations to design jobs in different ways and control work performed in remote locations. This article examines how telework can be used to provide benefits to organizations and their members. In it I present the findings of a study of a large Canadian financial services organization preparing to introduce telework into its sales and customer service operations. These findings highlight the role of expectancy in forming attitudes toward telework, most importantly: the extent to which face‐to‐face communication prevents important social needs from being satisfied and prevents workers from developing a sense of belonging and commitment to the organization; and the belief that telework will bring improved performance results by creating a work environment with fewer distractions and new, more objective performance measures based on output. This exploration of individuals’ willingness to telework is apt because it points to potential sources of resistance to the implementation of new technologies of production and control in the workplace.
Simulation usage in SMEs

Purpose – The purpose of this paper is to accurately model the existing manufacturing processes of a family‐owned small to medium‐sized enterprise (SME). The study was undertaken to provide the SME with information, so that potential improvements within the production facilities could be identified thereby leading to insights into potential savings, and waste elimination. Ultimately the research attempts to demonstrate that small businesses can benefit from adopting simulation as a decision‐making tool as part of their change management initiatives.Design/methodology/approach – The research methodology is a case‐based simulation study of the production facilities of a SME. A base model and successive experimental models were developed to test various production scenarios.Findings – The experiments demonstrated how simulation could contribute and assist in the implementation of TQM and change management philosophies within a SME environment. The initial models identified problems in the real system and the.
Software Innovativeness: A Comparison between Proprietary and Free/Open Source Solutions Offered by Italian SMEs

Innovation processes taking place in the software sector are already widely debated. The widespread success of Free/Open Source Software (FOSS) raises new research issues, dealing with whether and how the free circulation of ideas championed by the movement and its collective management of intellectual property rights fosters innovation. The aim of this paper is to contribute to the literature by addressing the following research questions: are programs based on FOSS solutions more innovative than proprietary ones, and, if so, which innovation dimensions are typical of the FOSS production mode? Based on a sample of 134 software solutions produced by Italian Small and Medium Enterprises and using a methodology frequently applied in technology management to evaluate innovativeness of products and services, this exploratory study provides initial insights into what happens when alternative metrics are used to observe complex innovation processes in the software market.
Influence of ownership structure and corporate performance precrisis: evidence from Thailand

This study examines the effect of ownership structure on corporate performance of Thai non-financial firms between 1993 and 1996. The ownership structure is considered as: 1. concentrated ownership, 2. different types of concentrated ownership and 3. managerial ownership. It adopted Market Returns (MR) and accounting ratios as measures of performance. It reports that there is a positive association between concentrated ownership and firm performance. The results show that different types of concentrated ownership have positive relationships to performance measures. It, however, does not find any evidence to support the existence of a non-linear relationship between managerial ownership and firm performance.
Innovation policy, services and internationalisation: the role of technology centres

Globalisation compels firms to undertake internationalisation strategies in different ways. Recent research explains that part of a firm's international potential depends upon its networks. Technology centres play a key role in these networks: they belong to the territorial innovation system and supply knowledge-intensive services. The empirical evidence contained here shows a positive association between the use of services provided by technology centres and exportation, especially in the case of firms operating in R&D-intensive sectors.
Expiratory asynchrony in proportional assist ventilation.

One of the proposed advantages of proportional assist ventilation (PAV) has been the automatic synchrony between the end of the patient's inspiratory effort and the ventilator cycle (i.e., expiratory synchrony). However, recent clinical studies have shown a prolonged ventilator inspiratory time or even a "runaway" phenomenon with the normal use of PAV. We hypothesize that control-system delay may account for this, because in reality there is always some degree of delays between control-system's input and output in all ventilators. Computer simulation study to date has not taken into account the potential effect of control-system delay on expiratory synchrony. We therefore created a computer model in which the parameter of control-system delay time was introduced. We found that significant expiratory asynchrony may occur with this more realistic model of PAV. The ventilator flow termination may fall behind the completion of the patient inspiration by as long as 0.33 seconds under the selected simulation conditions. The inspiratory termination delay time is in proportion to the control-system delay time, the respiratory time constant, and the assist gain settings. In conclusion, this model indicates that due to the unavoidable control-system delay in the ventilators, expiratory asynchrony may be an inherent shortcoming associated with PAV.
Reconstruction of the Bone‐Bone Marrow Organ by Osteogenin, a Bone Morphogenetic Protein, and Demineralized Bone Matrix in Calvarial Defects of Adult Primates

Information concerning the efficacy of osteogenin, a bone morphogenetic protein, and demineralized bone matrix in orthotopic sites in nonhuman primates is a prerequisite for potential clinical application in humans. After exposure of the calvaria, 84 cranial defects, 25 mm in diameter, were prepared in 26 adult male baboons (Papio ursinus). Defects were implanted with insoluble collagenous bone matrix (ICBM, the inactive collagenous residue after dissociative extraction of bone matrix with 4 M guanidine hydrochloride) reconstituted with osteogenin fractions isolated from baboon bone matrix by chromatography on heparin-Sepharose and hydroxyapatite-Ultrogel (Og Hep-HA) or osteogenin further purified using Sephacryl S-200 gel filtration chromatography (Og S-200). Baboon osteogenin with the highest biologic activity in a rodent bioassay, as determined by alkaline phosphatase activity, calcium content, and histologic analysis, was used for orthotopic implantation in baboons. Additional defects were implanted with baboon demineralized bone matrix (DBM) or ICBM without osteogenin as control. Defects also were grafted with corticocancellous bone harvested from the iliac crest or left ungrafted to monitor the spontaneous regeneration potential of the adult baboon calvaria. Undecalcified bone sections at 7 μm were prepared from the harvested specimens 30 and 90 days after surgery. Histomorphometry demonstrated that Og S-200 induced copious amounts of bone and osteoid as early as day 30 (P < 0.01 versus ICBM, autogenous grafts and untreated defects). At day 90, in implants of Og S-200, Og Hep-HA, and DBM, bone and marrow formation was extensive, culminating in complete regeneration of the craniotomies. In implants of DBM, bone formed with an intervening phase of cartilage development. This provides the phenotypic evidence of endochondral bone differentiation by induction in defects of membranous calvarial bone in adult primates. These results establish the potential therapeutic application of osteogenin and demineralized bone matrix for the architectural reconstruction of the bone-bone marrow organ in humans.
Expression of GABA transporters on bullfrog retinal Müller cells

γ‐Aminobutyric acid (GABA) transporters (GATs) are involved in regulating GABAergic transmission through the high‐affinity uptake and release of GABA. In the present work, the expression of different subtypes of GATs (GAT‐1, GAT‐2, and GAT‐3) on Müller cells was investigated both immunocytochemically and electrophysiologically in the bullfrog retina. Double‐labeling experiments of glial fibrillary acidic protein (GFAP), a specific marker for Müller cells, and GATs showed that the somata, major processes, endfeet, and even branchlets of almost all Müller cells strongly expressed GAT‐1 on the membrane, whereas the main trunks and endfeet of about 80–90% Müller cells were moderately GAT‐2 labeled. No GAT‐3 immunoreactivity was observed in Müller cells. Meanwhile, using the whole‐cell recording technique, GAT‐mediated currents were recorded from Müller cells in the retinal slice preparation, and they were reversibly blocked by removal of extracellular Na+ and spread more or less evenly over the surface of these cells. Furthermore, the GATs on the Müller cells were sensitive to both nipecotic acid and β‐alanine, GABA uptake blockers. Taken together, the complementary immunocytochemical and electrophysiological results suggest that bullfrog Müller cells express functional GAT‐1 and GAT‐2, which may regulate GABAergic transmission by either taking up or releasing GABA, or both. GLIA 31:104–117, 2000. © 2000 Wiley‐Liss, Inc.
Prevalence and awareness regarding diabetes mellitus in rural Tamaka, Kolar

Background: The worldwide prevalence of diabetes mellitus has risen dramatically in the developing countries over the past two decades. Regular screening of adults is essential for early detection and care. There are limited studies on diabetes awareness and prevalence in rural communities. Hence this prevalence and knowledge assessment study was undertaken. Such data are extremely important to plan the public health policies with specific reference to implementation of National Diabetic Control Program. Aims: To study the prevalence and awareness of diabetes mellitus in rural areas. Settings and Design: Cross-sectional, household study. Materials and Methods: A study on adults and elderly age group in Tamaka village was undertaken. Structured questionnaire was used to assess the knowledge of diabetes and capillary blood screening tests done to detect diabetes. Statistical Analysis Used: SPSS - 11 software. Results and Conclusions: Ten per cent of the 311 adults screened had hyperglycemia. Half of the interviewed population had some awareness about diabetes and its symptoms. But more than half (75%) of them were not aware of the long term effects of diabetes and diabetic care. The common perception about diet in diabetes was to avoid sweets, rice and fruits and to consume more ragi, millet and wheat chapattis. Diabetes in young adults is common. Relevant knowledge about diabetes is poor in rural population. Hence community level awareness programs have to be organized. Healthcare providers must be aware of community perceptions and practices.