Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effect of Glycaemic Control on Fibrinolytic Parameters in Diabetic Patients with or without Background Retinopathy

Division of Endocrinology and Metabolism Akdeniz University School of Medicine 07070, ANTALYA Tlf: 242-2274343/35340 Fax: 242-2274490 E-mail: umit@hipokrat.med.akdeniz.edu. tr (1-3). Activity of the fibrinolytic system in diabetic patients was found to be increased (4-10), decreased (11-14) or unchanged (15) in several studies. However, most studies indicate hypofibrinolysis leading to increased coagulation. Hypofibrinolysis may occur due to reduced expression of tissue plasminogen activator (t-PA) (16), which is the most important activator of plasminogen, or increased plasminogen activator inhibitor-1 (PAI1) (17-19), which binds to t-PA and forms t-PA-
It's Got the Look: The Effect of Friendly and Aggressive “Facial” Expressions on Product Liking and Sales

When designing their products, companies try to employ shapes that are both emotionally appealing and compatible with the brand's image. One way to accomplish these aims is to anthropomorphize a product's appearance. The current research investigates how people decode emotional “facial” expressions from product shapes and how this affects liking of the design, using three studies in the domain of cars and one in the domain of cellular phones. In accordance with theories on the perception of human faces, the first study shows that perception of friendliness is limited to the grille (mouth), while aggressiveness can be communicated with both grille and headlights (eyes). The next study examines the best-liked combination of these two emotional expressions and finds that consumers prefer the combination of an upturned (friendly) grille with slanted (aggressive) headlights. The authors further explain this finding on a process level by showing that this combination triggers a positive affective state of both high pleasure and arousal. The third study validates the results with automobile sales data, and a fourth study extends the findings to another product category.
A Behavioral Economics Exploration into the "Volatility Anomaly * "

Contrary to a commonsense view in traditional finance theories to the effect that expected returns on investments in high-risk securities are higher than those in low-risk investments, in the actual stock market, there are negative correlations, respectively, between the beta value of individual securities measured beforehand and the actual returns realized later, and between the idiosyncratic volatility measured beforehand and the actual returns realized later. Here we, based upon the empirical studies of investor behaviors in the Japanese stock market, present the fact that, behind the “beta anomaly,” there is a preference for high-beta securities by typical institutional investors whose mandate is to beat a benchmark, and also that, behind the “idiosyncratic volatility anomaly,” there is a preference for positively skewed securities by individual investors, especially those engaged in margin trading, who overweight low tail probabilities assigned to the state of the world in which they make a lot of money by investing in the positively skewed stock, which could be called a “gambling preference. ”
Pumice‐pumice collisions and the effect of the impact angle

Using a high‐speed video camera, we studied oblique collisions of lapilli‐size pumice cylinders (with no rotation before impact) on flat pumice targets. Our results show that the rebound angle, the ratios of the components of velocities and the energy loss vary with the impact angle. In particular, in collisions with an average yaw angle approximately equal to zero, we observed relatively larger rebound angles at small and large impact angles and smaller values in between (the angles are measured from the horizontal surfaces of the targets). We observed also that the ratio of the normal components of velocities decreases and the ratio of the horizontal components increases when the impact angle increases. Furthermore, the ratio of the kinetic energy after to that before collisions, in general, decreases when the impact angle increases. Thus, our experiments reveal features that could be useful in modelling pumice‐pumice collisions in geophysical flows.
Regulatory Contributors to Children's Kindergarten Achievement

The present study sought to examine whether preschool children's emotion regulation, problem behaviors, and kindergarten behavioral self-regulation in the classroom were predictors of kindergarten achievement scores. The children (N = 122, 47% male and 63% European American) who were participating in an ongoing longitudinal study, were seen at both a preschool and kindergarten assessment. The present study examined the relation between parent report, teacher report, and laboratory measures of regulation and children's achievement test scores. Children's emotion regulation and behavioral self-regulation in the classroom were related to all measures of achievement. The relation between preschool emotion regulation and kindergarten achievement was mediated by behavioral self-regulation in the kindergarten classroom. In addition, all measures of regulation were correlated, suggesting that some children who have difficulty regulating their behavior in one setting (such as home) may also have difficulty with regulation in other settings (such as school).
Patient resistance towards diagnosis in primary care: Implications for concordance

This article reports a conversation analytic study of patients’ resisting responses after doctors’ diagnostic statements. In these responses, patients bring forward information that confronts the doctor’s diagnostic information. We examine two turn formats — aligning and misaligning — with which patients initiate resistance displays, and describe conversational resources of resistance the patients resort to: their immediate symptoms, their past experiences with similar illness conditions, information received in past medical visits and their diagnostic expectations that have been established earlier in the consultation.Through the deployment of these resources, patients orient to the doctor’s diagnostic information as negotiable and seek to further a shared understanding with the doctor on their condition. The results are discussed with regard to concordance as a process in which patients and doctors arrive at a shared understanding on the nature of the illness and its proper treatment. Our analysis illuminates the mechanisms in interaction in and through which concordance can be realized. Thus, we suggest that concordance can be seen to encompass not only treatment discussion but also the process where participants reach agreement about the diagnosis. The data of the study consist of 16 sequences of patients’ resisting responses to diagnosis and is drawn from 86 Finnish primary care visits for upper respiratory tract infections.
Consumer adoption of online grocery buying: a discriminant analysis

Purpose – To empirically investigate whether consumers who have adopted online grocery buying perceive this way of shopping differently from other online consumers.Design/methodology/approach – The data presented in this study were collected from an online (web‐based) survey of US consumers using self‐administered questionnaires. Data from 784 US online consumers are analyzed.Findings – Multiple discriminant results suggest that online grocery shopping adopters attach higher compatibility, higher relative advantage, more positive social norms, and lower complexity to internet grocery shopping both compared with consumers who have never bought anything on the internet yet and also compared with consumers who have purchased goods/services on the internet but not groceries. The results also suggest that online grocery shopping adopters have higher household incomes than non‐adopters.Research limitations/implications – This research used a single respondent as a household representative. Since grocery buying .
Lack of Mycobacterium tuberculosis–specific interleukin‐17A–producing CD4+ T cells in active disease

Protective immunity to Mycobacterium tuberculosis (Mtb) is commonly ascribed to a Th1 profile; however, the involvement of Th17 cells remains to be clarified. Here, we characterized Mtb‐specific CD4+ T cells in blood and bronchoalveolar lavages (BALs) from untreated subjects with either active tuberculosis disease (TB) or latent Mtb infection (LTBI), considered as prototypic models of uncontrolled or controlled infection, respectively. The production of IL‐17A, IFN‐γ, TNF‐α, and IL‐2 by Mtb‐specific CD4+ T cells was assessed both directly ex vivo and following in vitro antigen‐specific T‐cell expansion. Unlike for extracellular bacteria, Mtb‐specific CD4+ T‐cell responses lacked immediate ex vivo IL‐17A effector function in both LTBI and TB individuals. Furthermore, Mtb‐specific Th17 cells were absent in BALs, while extracellular bacteria‐specific Th17 cells were identified in gut biopsies of healthy individuals. Interestingly, only Mtb‐specific CD4+ T cells from 50% of LTBI but not from TB subjects acquired the ability to produce IL‐17A following Mtb‐specific T‐cell expansion. Finally, IL‐17A acquisition by Mtb‐specific CD4+ T cells correlated with the coexpression of CXCR3 and CCR6, currently associated to Th1 or Th17 profiles, respectively. Our data demonstrate that Mtb‐specific Th17 cells are selectively undetectable in peripheral blood and BALs from TB patients.
Monitoring Role of Financial Intermediaries and Design of a Market Model for Monitoring Under Market-Based Financing

Matching the suppliers and users of funds, financial intermediaries convey information from one to the other and are required to monitor fund-users on behalf of the suppliers. Bank-based financing is dominantly the theoretical arena in researching the monitoring role of financial intermediaries. We claim that market-based financing suffers from the vulnerability of not having a clear mandate for intermediaries to monitor. The indirect mechanisms, namely auditing and rating services, corporate governance principles, disclosure requirements, do not fulfill the informative and monitoring role of the intermediaries in market-based financing though this role is inherently assumed in bank-based financing. To fix this flaw, we tempt to develop a market model for financial intermediaries to monitor fund-raisers under market-based financing.
Haloanisole and halophenol contamination in Spanish aged red wines

This is the first study to be carried out on the incidence of halophenols and haloanisoles, including trichloroanisole, in aged red wines. A total of 966 red wines, aged for 6, 12 and 24 months in oak barrels and from different Spanish production areas, were analysed by stir bar sorptive extraction followed by gas chromatography/mass spectrometry (GC/MS). From the wines sampled, 155 (16.1%) were contaminated with one or several compounds, with 7.6, 6.9 and 1.5% corresponding to the 12- (aged-12), 6- (aged-6) and 24-month-aged (aged-24) wines, respectively. The most abundant compounds causing taint were 2,3,4,6-tetrachloroanisole and 2,4,6-trichloroanisol (6.8 and 5.3%, respectively). No 2,4,6-tribromophenol was found in any of the samples. Contamination with halo compounds was highest in samples from South-West Spain, followed by those from Northern Spain. The mean concentration for all compounds were always higher than their respective olfactory threshold, but none of these halo compounds represent a health hazard to humans through the consumption of commercial red aged wines.
Neuropsychiatric evaluation of patients with brucellosis

Brucellosis is a multisystem disease that may present with a broad spectrum of clinical manifestations. Neurobrucellosis is one of the complications. The objective of this study was to determine neuropsychiatric manifestations among patients with brucellosis. Twenty-seven consecutive patients with brucellosis (14 patients with manifest neurological manifestation and 13 patients without apparent neurological manifestation) were recruited from Assiut University hospital and compared with 50 healthy controls matched with respect to age, sex, and social economic and educational levels. They were subjected to systemic, meticulous neuropsychiatric evaluations, laboratory, radiological, neurophysiology, and psychometric assessment with Mini-Mental State Examination, Wechsler Memory Scale—Revised. and Hamilton Depression Rating. Overt or apparent neurological manifestation was recorded in 14 patients (51.85%) and 13 patients (48.15%) with brucellosis without apparent neuropsychiatric involvement. Central nervous system (CNS) involvement (vascular stroke, meningeoencephalitis, and dementia) was recorded in 9 patients (33.3%) and 6 patients (22.2%) had peripheral nervous sytem (PNS) involvement (polyneuropathy, radiculoapathy, and polyradiculoneuropathy). Depression was recorded in 7 (29.2%) patients; 3 patients (21.4%) of the neurobrucellosis group and 4 patients (30.8%) with brucellosis without neurological manifestations. Patients with brucellosis (neurobrucellosis and patients without neurological manifestations) reported highly significant impairment in some cognitive function measures (mental control, logical memory, visual reproduction) and higher scores on depressive symptoms compared with controls. Patients with a Brucella infection usually manifest central nervous system involvement. Clinicians, especially serving in endemic areas or serving patients coming from endemic areas, should consider the likelihood of neurobrucellosis in patients with unexplained neurological and psychiatric symptoms, and should perform the necessary tests, including cognitive function and depression tests.
Loop-Like Process of Knowledge Transfer: Diffusion of New Technology in the International Civil Aviation Domain

In past studies, the knowledge transfer process was illustrated as a four-stage serial process comprising the following stages: initiation, implementation, ramp-up, and integration. However, actual cases on the knowledge transfer process indicated a deviation from this model. This study proposes a modified process model by collecting and analyzing knowledge transfer data on new technology in the civil aviation domain. In the proposed modified model, the ramp-up stage (in which the transferred knowledge is utilized) and the integration stage (in which the knowledge is integrated into an organizational routine) have a reciprocal relationship. In other words, in the knowledge transfer process, (1) initial routine is established by the recipient of the knowledge, (2) transferred knowledge is utilized according to the initial routine, and (3) the routine is continuously amended based on feedback obtained through the usage of the knowledge. Although this modified knowledge transfer process needs to be validated with empirical research, it seems to provide a better explanation for the actual knowledge transfer process.
Exploratory Study of the Adoption and Use of the Smartphone Technology in Emerging Regions: Case of Saudi Arabia

This Dissertation is brought to you for free and open access. It has been accepted for inclusion in Dissertations and Theses by an authorized administrator of PDXScholar. For more information, please contact pdxscholar@pdx.edu. Recommended Citation Aldhaban, Fahad Abdulaziz, "Exploratory Study of the Adoption and Use of the Smartphone Technology in Emerging Regions: Case of Saudi Arabia" (2016). Dissertations and Theses. Paper 2651.
Response to a novel multitargeted tyrosine kinase inhibitor pazopanib in metastatic Merkel cell carcinoma.

A 69-year-old woman presented with a 2-year history of gradually increasing scalp swelling in December 2001. The patient was in good general condition, but physical examination revealed a 5-cm fleshy tumor on the right scalp, with pathology consistent with Merkel cell carcinoma on excisional biopsy. A metastatic work-up, including computed tomography (CT) of the thorax and abdomen, mammography, and gastroscopy, was negative, and the patient underwent a subsequent wide excision with superficial skin graft. No adjuvant radiotherapy was administered at this time. In August 2002, the patient had a local recurrence of a bulky 12-cm mass fixed to the skull, and biopsies of the right upper deep cervical and supraclavicular lymph nodes were inconclusive for involvement. The tumor was inoperable, and the patient underwent radical radiotherapy for a total of 70 Gy, with excellent response at all tumor sites. In March 2003, two small nodules developed in the field, which were believed to represent either soft tissue radionecrosis or possibly a second local recurrence. In October 2003, the patient underwent repeat wide excision with right level II to V neck dissection for nodal and scalp tumor recurrence. Histopathologic examination of the tissue revealed Merkel cell carcinoma with eight of 19 positive lymph nodes and negative margins. The tissue was strongly positive for neuron-specific enolase, with cytoplasmic and perinuclear dot positive for AE1/3, CAM5.2, and epithelial membrane antigen (Fig 1A). Synaptophysin was focally positive, whereas S-100 protein was weakly staining, and chromogranin was negative. CT of the thorax/abdomen revealed multiple pulmonary lesions consistent with metastatic disease. The patient was given six cycles of carboplatin with etoposide, and achieved a partial response. In July 2004, a 1.6 1.2 cm right neck mass developed just deep to the flap with a necrotic center at C2-C3, and the pulmonary metastases also showed progression on follow-up CT. The patient underwent repeat wide excision of the neck mass, and postoperative chemotherapy was begun with weekly paclitaxel. Stable disease was maintained until December 2004, when pulmonary metastases progressed, and a 2.3-cm subcarinal lymph node was noted on CT. The patient enrolled onto a clinical trial of tegafur, 5-chloro-2,4dihydroxypyridine, and oxonic acid (S1) at 30 mg/m twice daily. A partial response of the pulmonary metastases was achieved, and the patient continued to receive S1 for 35 cycles until relapse occurred in December 2006, with a 1.5-cm nodule above the right ear. Fine-needle aspiration of the nodule was consistent with Merkel cell carcinoma. The patient was observed closely until April 2007, when the right ear mass had grown to 3.5 cm, and pulmonary metastases had progressed on CT imaging. The patient was enrolled onto a clinical trial of a novel multitargeted tyrosine kinase inhibitor pazopanib at 800 mg daily after written informed consent was provided according to institutional guidelines. Consent to use her data for this report was obtained and A B
Changes in the epidemiology of hepatitis C infection in Germany: Shift in the predominance of hepatitis C subtypes

Hepatitis C virus (HCV) subtype distribution was studied in 395 chronically infected patients from Germany. HCV genotype 1 was most frequent (80.5%). One hundred forty‐three individuals (36.2%) were infected with subtype 1a and 175 (44.3%) were suffering from subtype 1b infection, respectively. HCV subtype 3a was found in 53 (13.42%) persons. Subtypes 2a, 2b, and 2c have been detected in 5 (1.27%), 10 (2.53%), and 4 (1.01%) individuals. Genotypes 4 and 5a accounted for HCV infections in 4 (1.01%) and 1 (0.25%) subjects. There was a notable variation in the distribution of the prevalent subtypes 1a and 1b in different age groups. Subtype 1a was detected in 53.3% and 68.0% of patients aged 1–10 and 11–20 years, whereas subtype 1b in the same groups was present only in 33.3% and 28.0% of patients, respectively. In contrast, in individuals older than 50 years subtype 1b was most frequent. Thus, subtype 1b has been gradually substituted for subtype 1a during the last 20 years. Logistic regression analysis with adjustment for sex and different modes of HCV acquisition demonstrated that age of the infected subjects was a direct explanatory variable for subtype 1a and 1b distribution. Therefore, the observed shift in HCV subtype prevalence could not be attributed to changes in the epidemiological relevance of different known risk factors of HCV transmission, as had been assumed in previous studies. The altered subtype pattern reported here may have a profound influence on the future epidemiology of HCV infection. J. Med. Virol. 60:122–125, 2000. © 2000 Wiley‐Liss, Inc.
Selecting techniques for use in an internet survey

Purpose – The paper's aim is to illustrate the use of a technique that can help researchers choose which techniques, and at what level, to employ in an internet‐based survey.Design/methodology/approach – A screening experiment, designed as a Plackett‐Burman design, is used to study main effects of 11 techniques for increasing survey response. Three measures of effect used are click rate, completion rate, and response rate. A convenience sample of students at a large university in New Zealand is used.Findings – Follow‐up had significant impact on click rate; incentive and pre‐notification had a significant impact on completion rate; no technique had significant effect on response rate.Research limitations/implications – Main effects are examined. Also, a limited number of approaches for each technique are studied.Originality/value – This paper illustrates the use of a methodology that researchers, practitioner, and academics alike, can use to select techniques to employ in an internet survey. This is the f.
Striatal AMPA Receptor Binding Is Unaltered in the MPTP-Lesioned Macaque Model of Parkinson's Disease and Dyskinesia

Long-term levodopa or dopamine agonist treatment in the MPTP-lesioned primate model of Parkinson's disease elicits dyskinesia, which is phenotypically similar to levodopa-induced dyskinesia in patients with Parkinson's disease. AMPA receptor antagonists have previously been shown to have both anti-parkinsonian and anti-dyskinetic actions in MPTP-lesioned primates, suggesting that AMPA receptor transmission is functionally overactive under these conditions. In this study, we investigated the level of striatal AMPA receptor binding in the MPTP lesioned primate using the selective AMPA ligand (3)H-(S)-5-fluorowillardiine. AMPA receptor binding was studied in non-parkinsonian, non-dyskinetic parkinsonian, and dyskinetic macaques. Striatal AMPA receptor binding was not different in any of the treatment groups (P > 0.05). Although AMPA receptor-mediated transmission is functionally overactive in Parkinson's disease and dyskinesia, changes in striatal AMPA receptor levels are not likely to be the cause of such movement disorders.
Factors Militating Against the Global Competitiveness of Manufacturing Firms in Nigeria

The research efforts in this article have been geared towards identifying the factors militating against the global competitiveness of manufacturing firms in Nigeria. The major challenges and problems of the sector include: deteriorating and poor infrastructures; high production costs; inconsistent government policies on the sector; severe competition from imported goods; limited scope of operation; financial constraints; among a myriod of other impediments. To be a developed economy, Nigeria should have a strong and dynamic manufacturing sector. To enable Nigeria to be one of the twenty biggest economics in 2020, in line with the government Vision 20:2020, this article made far reaching recommendations which should be implemented religiously.