Miracle-dz/UniFAR-FTUs huggingface dataset:
DIRECT EVIDENCE FOR A ROLE OF β‐CATENIN/LEF‐1 SIGNALING PATHWAY IN INDUCTION OF EMT

Epithelial‐mesenchymal transformation (EMT) is an important process in development that is characterized by loss of E‐cadherin, β‐catenin relocalization, and acquisition of elongated cell shape and ability to invade ECM. β‐catenin has been shown to activate LEF‐1 transcription during EMT induced in vitro by c‐Fos. Here, we ask whether or not LEF‐1 directly introduced into epithelial cells in an adenovirus construct can induce EMT. In normal epithelial cell lines, such as HCE and MDCK cells, that contain functional APC, nuclear β‐catenin induced by exogenous LEF‐1 is rapidly exported and EMT is not induced. Leptomycin‐B blocks β‐catenin nuclear export, but no EMT occurs due to toxicity. Addition of Wnt‐1 to normal epithelial cell lines stabilizes cytoplasmic β‐catenin that LEF‐1 then transports to nuclei, causing a small amount of EMT. Our experiments demonstrated, however, that overexpressed LEF‐1 upregulates nuclear β‐catenin and promotes dramatic EMT in DLD‐1 epithelial tumors that retain nuclear β‐catenin. This EMT is reversible if the LEF‐1 virus is removed. Thus, our results demonstrate that LEF‐1 can induce EMT directly when its transcription activity is activated by stable nuclear β‐catenin. Normal adult epithelial cells appear to use APC to keep β‐catenin out of the nucleus, thereby avoiding pathologies such as metastases due to LEF/β‐catenin‐induced EMT.
Comparative evaluation of the acute and chronic effects of cilazapril and hydrochlorothiazide on diastolic cardiac function in hypertensive patients.

UNLABELLED The effect of cilazapril, 2.5 to 5.0 mg and hydrochlorothiazide, 25 to 50 mg, on diastolic cardiac function was studied by echocardiography and radionuclide ventriculography, using a double-blind randomized parallel-group design with a placebo run-in period, in 30 hypertensive patients. The measurements were made before and three hours after the first dose, and after ten weeks of treatment. Both drugs lowered the elevated blood pressure and did not impair the normal systolic cardiac function. In the patients treated with cilazapril an improvement in indices of diastolic function was observed after the first dose. The normalized peak filling rate significantly increased from 2.4 +/- 0.7 to 2.7 +/- 0.7 counts and time to peak filling rate was shortened from 169.4 +/- 31.0 to 151.6 +/- 40.1 msec. This improvement was sustained or even enhanced during chronic therapy. In contrast hydrochlorothiazide acutely impaired one index of diastolic function, the normalised peak filling rate, and did not alter the other indices. Long-term treatment with cilazapril, but not with hydrochlorothiazide, caused regression of left ventricular hypertrophy. IN CONCLUSION cilazapril is superior to hydrochlorothiazide in its effect on diastolic cardiac function in hypertensive patients. The beneficial effect is partially related to regression of left ventricular hypertrophy.
[Principles of personnel management].

From the combination of knowledge and actions, someone can improve their skill and ability. It will lead them to live and work much better. This is why, the students, workers, or even employers should have reading habit for books. Any book will give certain knowledge to take all benefits. This is what this principles of personnel management tells you. It will add more knowledge of you to life and work better. Try it and prove it.
Isometry of AdS2 and the c = 1 matrix model

Implications of the SL(2,) symmetry of the c = 1 matrix models are explored. Based on the work of de Alfaro, Fubini and Furlan, we note that when the Fermi sea is drained, the matrix model for 2 dimensional string theory in the linear dilaton background is equivalent to the matrix model of AdS2 recently proposed by Strominger, for which SL(2,) is an isometry. Utilizing its Lie algebra, we find that a topological property of AdS2 is responsible for quantizing D0-brane charges in type 0A theory. We also show that the matrix model faithfully reflects the relation between the Poincare patch and global coordinates of AdS2.
Detection of Epstein‐Barr virus (EBV) genomes in the serum of patients with EBV‐associated Hodgkin's disease

DNA from malignant cells is present in the serum/plasma of cancer patients and DNA from this source is amenable to analysis by polymerase chain reaction (PCR). In the present study, we evaluated whether Epstein‐Barr virus (EBV) DNA is present in the serum of patients with EBV‐associated Hodgkin's disease (HD). Using conventional PCR, EBV DNA was detected in serum from 30/33 patients with EBV‐associated HD but in only 6/26 patients with non‐EBV‐associated disease (p < 0.001). Samples from healthy individuals were negative and only 5/12 infectious mononucleosis samples were positive. Real‐time quantitative PCR was subsequently employed to determine the concentration of EBV DNA present in serum; among positive samples the level ranged from 1 to 705 copies per 125 μl of serum. Post‐treatment samples from 5/14 cases with EBV‐associated HD contained detectable EBV DNA; analysis of this small group of cases suggests that positivity in post‐treatment samples correlates with risk factors indicative of a poor prognosis. Overall, our results are consistent with the notion that DNA from Reed‐Sternberg cells is present in the serum of HD patients, and further suggest that serum EBV should be evaluated as a prognostic marker. Int. J. Cancer (Pred. Oncol.) 84:442–448, 1999. © 1999 Wiley‐Liss, Inc.
Evidence for the Emergence of Non-O1 and Non-O139 Vibrio cholerae Strains with Pathogenic Potential by Exchange of O-Antigen Biosynthesis Regions

ABSTRACT The novel epidemic strain Vibrio cholerae O139 Bengal originated from a seventh-pandemic O1 El Tor strain by antigenic shift resulting from homologous recombination-mediated exchange of O-antigen biosynthesis (wb*) clusters. Conservation of the genetic organization of wb* regions seen in other serogroups raised the possibility of the existence of pathogenic non-O1 and non-O139 V. cholerae strains that emerged by similar events. To test this hypothesis, 300 V. cholerae isolates of non-O1 and non-O139 serogroups were screened for the presence of virulence genes and an epidemic genetic background by DNA dot blotting, IS1004 fingerprinting, and restriction fragment length polymorphism (RFLP) analysis. We found four non-O1 strains (serogroups O27, O37, O53, and O65) with an O1 genetic backbone suggesting exchange of wb* clusters. DNA sequence analysis of the O37 wb* region revealed that a novel ∼23.4-kb gene cluster had replaced all but the ∼4.2-kb right junction of the 22-kb O1 wbe region. In sharp contrast to the backbones, the virulence regions of the four strains were quite heterogeneous; the O53 and O65 strains had the El Tor vibrio pathogenicity island (VPI) cluster, the O37 strain had the classical VPI cluster, and the O27 strain had a novel VPI cluster. Two of the four strains carried CTXφ; the O27 strain possessed a CTXφ with a recently reported immune specificity (rstR-4** allele) and a novel ctxB allele, and the O37 strain had an El Tor CTXφ (rstRET allele) and novel ctxAB alleles. Although the O53 and O65 strains lacked the ctxAB genes, they carried a pre-CTXφ (i.e., rstRcla). Identification of non-O1 and non-O139 serogroups with pathogenic potential in epidemic genetic backgrounds means that attention should be paid to possible future epidemics caused by these serogroups and to the need for new, rapid vaccine development strategies.
Concept analysis of pain: implications related to nursing diagnoses.

Pain is a phenomenon that has an impact on clients in a variety of settings. Nurses have many responsibilities related to assessment, diagnosis, intervention, and evaluation when caring for the person experiencing pain. The phenomenon of pain is described through a concept analysis, which is guided by the research tradition of phenomenology. A review of both medical and nonmedical literature provides a broad base of definitions from which the attributes, antecedents, and consequences are derived. The analysis includes the construction of various cases and identification of empirical referents in the phenomenologic tradition. Suggestions for future development and implementation of the concept into clinical nursing practice and clinical nursing research are included.
A High-Gain, Two-Stage, X-Band SiGe Power Amplifier

SiGe technology is becoming well-known for its capabilities as a high-speed IC design platform, and is being increasingly employed to address a wide variety of communications circuit applications. Unfortunately, the ever-increasing speed of the requisite SiGe transistors comes at a cost that significantly constrains their use in power amplifier design: available breakdown voltage. We demonstrate here that by using an optimized cascode amplifier architecture employing both the high speed (low breakdown voltage) and high breakdown voltage (low speed) SiGe transistors, one can relax these design constraints considerably. Using this approach, a two stage, X-Band amplifier has been fabricated exhibiting maximums of more than 40 dB of stable gain, an output power greater than 20 dBm, and a power-added efficiency of 25% over the X-band operating frequency of 8.5 to 10.5 GHz, and is suitable for emerging X-band phased array radar applications.
Toward interventions to address moral distress

Background: The concept of moral distress has been the subject of nursing research for the past 30 years. Recently, there has been a call to move from developing an understanding of the concept to developing interventions to help ameliorate the experience. At the same time, the use of the term moral distress has been critiqued for a lack of clarity about the concepts that underpin the experience. Discussion: Some researchers suggest that a closer examination of how socio-political structures influence healthcare delivery will move moral distress from being seen as located in the individual to an experience that is also located in broader healthcare structures. Informed by new thinking in relational ethics, we draw on research findings from neuroscience and attachment literature to examine the reciprocal relationship between structures and agents and frame the experience of moral distress. Conclusion: We posit moral distress as a form of relational trauma and subsequently point to the need to better understand how nurses as moral agents are influenced by—and influence—the complex socio-political structures they inhabit. In so doing, we identify this reciprocity as a framework for interventions.
Evaluation of Reading Speed with Four Low Vision Aids

ABSTRACT Four commonly prescribed low vision aids of equivalent power were evaluated to determine maximum reading speed of normally sighted young adults. Subjects tested were fully sighted and of similar educational backgrounds. Presentation of the four aids was designed to duplicate common clinical methods of evaluating these categories of aids. Limitations imposed under these conditions on reading speed by the optics of the four systems were determined. Maximum reading speed was attained with microscopes, followed by (in order) hand magnifiers, focusable telescopes, and stand magnifiers. Results have implications on clinicians' initial performance expectations for these categories of optical aids for patients having low vision.
Polar codes in a QKD Environment 1

Polar coding is the most recent encoding scheme in the quest for error correction codes that approaches the Shannon limit, has a simple structure, and admits fast decoders. As such, it is an interesting candidate for the quantum key distribution (QKD) protocol that normally operates at high bit error rates and requires codes that operate near the Shannon limit. This paper describes approaches that integrate Polar codes into the QKD environment and provides performance results of Polar code designs within the QKD protocol.
Computing Invariant Manifolds by Integrating Fat Trajectories

We present a new algorithm for computing invariant manifolds. The algorithm uses two main theoretical results, presented in the appendices: formulae for the evolution of a second order local approximation of a bundle of trajectories (which we call a fat trajectory), and a proof of the existence and a constructive means of locating points where k (the dimension of the manifold) trajectories diverge.Invariant manifolds can be defined as the image under the flow of a (k-1)-dimensional manifold of starting points. The algorithm uses local approximations at points spaced along trajectories starting on the manifold of starting points to partially cover the invariant manifold. To finish the covering it then iteratively interpolates and constructs fat trajectories starting at the interpolation points. Unlike other methods, the resulting algorithm does not use an adaptively refined front, and it allows errors to be controlled via the integration method used to find the fat trajectory and the width of the fat traje.
Self-Acceptance Mediates the Relationship between Mindfulness and Perceived Stress

Previous research has shown that the effects of mindfulness-based interventions and increased trait mindfulness are associated with reduced stress. Further research is needed to understand the mechanisms by which mindfulness-based interventions exert their beneficial effect on decreased stress. The purpose of the present study was to examine the role of self-acceptance in the relationship between trait mindfulness and perceived stress among a sample of 132 students from Beijing, China. Results revealed that self-acceptance was found to partially mediate the relationship between mindfulness and stress. Limitations, clinical implications, and directions for future research are identified.
Removal of impulse noise using a FIRE filter

FIRE (Fuzzy Inference Ruled by Else-action) operators are a family of nonlinear operators which adopt fuzzy rules to process image data. A new operator, called DS-FIRE filter, is presented in this paper for the enhancement of images corrupted by impulse noise. By performing fuzzy reasoning at two different levels, the operator is able to effectively cancel noise pulses without degrading the quality of fine details and textures. The new fuzzy rulebase and inference mechanism which have been specifically developed for this operator are described in details. Results of computer simulations show that the filter performs better than state-of the-art operators in the literature.
Effectiveness of physical therapy for patients with adhesive capsulitis: a randomized controlled trial.

OBJECTIVE To compare the effectiveness of a combined technique of physical and ibuprofen for the treatment of adhesive capsulitis with ibuprofen alone. MATERIAL AND METHOD 122 subjects were randomly allocated to have 3 weeks treatment either with ibuprofen (n=61) or ibuprofen and a combined technique of physical therapy (n=61). Outcome measures were carried out 3 weeks and 12 weeks after randomization. Primary outcome measures were the success of treatment measured by improvement in the Shoulder Pain and Disability Index, and global rating. RESULTS At 3 weeks, 21 (35.0%) of 60 patients in the study group were considered to have had successful treatment compared with 11 (18.6%) of 59 in the control group (difference between groups 16.4%, 95% CI: 4.0-31.3, p=0.044). There was no significant difference in the success rate between the two groups at the 12th week follow-up. CONCLUSION The results of this study support the use of physical therapy for patients with adhesive capsulitis.
Lay Knowledge of Dyslexia

This study looks at the extent to which lay people believe many myths associated with dyslexia. It examined attitudes and beliefs about the causes, manifestations and treatments for dyslexia in a British population sample. A community sample of 380 participants (158 Male; 212 Female) completed a 62-item questionnaire on their attitudes to, and beliefs about, dyslexia. The statements were derived from various “dyslexia facts and myths” websites set up to help people understand dyslexia; academic research papers; and in-depth exploratory interviews with non-specialist people regarding their understanding of dyslexia. Item analysis showed participants were poorly informed about many aspects of dyslexia. Factor analysis returned a structure of latent attitudes in five factors (Characteristics, Biological and Social Causes, Treatment and Prevention). Regression analysis revealed that participant political orientation and education (formal and informal acquaintances with dyslexia sufferers) were the best predictors of attitudes concerning the behavioural manifestations, aetiology and treatments of dyslexia. Limitations and implications of this research were considered.
Chloroplast Genome Analysis to Detect Transition Link between Bryophytes and Pteridophytes: A Bioinformatics Approach

Bryophytes (mosses, liverworts and hornworts) are the most basal lineages among extant land plants. However, there is controversy regarding their monophyletic or paraphyletic origin. Moreover, the most basal group of bryophytes also remains questionable. Due to this it is a matter of debate which lineage of bryophytes acts as transition link between bryophytes and pteridophytes. In order to resolve these issues we conducted a bioinformatics analysis on available chloroplast genomes of 1 green alga, 5 bryophytes, 4 pteridophytes, and 6 gymnosperms. Our study is based on multiple genome analysis through whole proteome comparison. The higher number of orthologous identified in Anthoceros (a hornwort), in comparison to other bryophytes considered, against all pteridophytes strongly support hornworts as transition link between bryophytes and pteridophytes.
The Effects of Trade Liberalization of the Environment: An Empirical Study

We seek to contribute to the emerging economic theory on trade, the environment and development. Using panel data across countries, econometric models are estimated to predict the effects of openness on organic water pollutant (BOD) and carbon dioxide (CO2) emissions. Results indicate that freer trade significantly increases emissions of both pollutants, thus reducing environmental quality. Moreover, the panel nature of the data allows heterogeneity across countries to be controlled, so that comparisons can be made of how different national characteristics influence the environmental impact of freer trade. By testing the effects of democratic versus autocratic governance, it is found that while greater democracy can induce significant reductions in BOD emissions as openness increases, it may also lead to increased CO2 levels. Meanwhile, by testing for and failing to reject the pollution haven hypothesis, it is suggested that environmental gains from openness in relatively rich countries may be coming at the expense of environmental degradation in poorer countries.
Occupational health research.

Professor W J MacLennan (4 June, p 1551) draws attention to the potential problems of giving diuretic drugs to elderly patients and the need for accurate diagnosis before prescribing these agents. We wish to emphasise a common misuse of diuretics in the elderly. We have often seen elderly patients referred to dermatology clinics who have been prescribed diuretics for leg oedema that is entirely caused by gravitational disease. The associated skin changes are often minimal or absent, and there are no symptoms or signs of other causes of the oedema. The results of diuretic treatment for leg oedema caused by gravitational disease are invariably disappointing, presumably because compensatory sodium retaining mechanisms operate. Withdrawal of the diuretics may cause rebound oedema, which can be misinterpreted as a sign that there is a continued need for them. ' The best measures to control gravitational oedema are regular daytime use of support hosiery, regular postural drainage ofthe legs, or, preferably, both. Occasionally patients may be unable to tolerate support hosiery, particularly when severe peripheral vascular disease is present. Postural drainage of the legs requires their elevation to at least 450 while lying down for 30-45 minutes twice a day. This may prove difficult for patients who have impaired hip mobility. In most patients, however, these measures are effective and well tolerated. If gravitational disease can be diagnosed after a thorough assessment to exclude other causes of leg oedema, using the above measures will avoid the hazards of unnecessary diuretic treatment in many elderly patients.
The Oaxaca–Blinder Unexplained Component as a Treatment Effects Estimator

In this paper I use the National Supported Work (NSW) data to examine the finite-sample performance of the Oaxaca–Blinder unexplained component as an estimator of the population average treatment effect on the treated (PATT). Precisely, I follow sample and variable selections from Dehejia and Wahba (1999), and conclude that Oaxaca–Blinder performs better than any of the estimators in this influential paper, provided that overlap is imposed. As a robustness check, I consider alternative sample (Smith and Todd 2005) and variable (Abadie and Imbens 2011) selections, and present a simulation study which is also based on the NSW data.
Functional anatomy of execution, mental simulation, observation, and verb generation of actions: A meta‐analysis

There is a large body of psychological and neuroimaging experiments that have interpreted their findings in favor of a functional equivalence between action generation, action simulation, action verbalization, and perception of action. On the basis of these data, the concept of shared motor representations has been proposed. Indeed several authors have argued that our capacity to understand other people's behavior and to attribute intention or beliefs to others is rooted in a neural, most likely distributed, execution/observation mechanism. Recent neuroimaging studies have explored the neural network engaged during motor execution, simulation, verbalization, and observation. The focus of this meta‐analysis is to evaluate in specific detail to what extent the activated foci elicited by these studies overlap. Hum. Brain Mapping 12:1–19, 2001. © 2001 Wiley‐Liss, Inc.
Mental Health and Depression among Working and Non- Working Women

The main purpose of this research was to find out the mean difference between working and non-working women in mental health and depression. The total sample consisted 80 women were taken. The research tool for mental health was measured by Dr. D.J. Bhatt and Gita R. Geeda (1992). While the tool for depression were used which made by Beck (1961). Here 't' test was applied to check the significance of mental health and depression in working and non-working women to check the correlation method is sued. Results revealed that significant difference in mental health and depression with respect to both working and non-working women on mental health and depression. While the correlation between mental health and depression reveals 0.71% high positive correlation.
Effects of Stress and Depolarization on Electrical Behaviors of Ferroelectric Field-Effect Transistor

The effects of stress and depolarization on current-voltage characteristics of ferroelectric field-effect transistor (FeFET) were investigated by Landau-Khalatnikov theory in conjunction with Pao and Sah's model. Output characteristics current increases under compressive stress but decreases under tensile stress. Transfer characteristics curve is enlarged by compressive stress but compressed by tensile stress, and it shifts to the negative voltage axis under compressive stress gradient while to the opposite direction under tensile stress gradient. Because of depolarization, output characteristics current is obviously affected, and transfer characteristics curve is seriously distorted. These results show that stress and depolarization should be considered in device design to prevent failure of FeFET.