Miracle-dz/UniFAR-FTUs huggingface dataset:
Emotional Intelligence: A Key for Nurses' Performance

Today, emotional intelligence (EI) is probed as an important characteristic for building successful nursing leadership, enhancing nursing performance and reducing nurse burnout. In nursing profession nurse-patient interaction is the pulse of the nursing practice. This interaction is not just conversation. It is a complex process that involves nurse perception, understanding of the patient emotions and utilization of the perceptions to manage patient situations towards the goal of effective patient care. Nurses with higher EI contribute to a higher-performing and more harmonious workplace. The aim of the study: is to examine the relationship between emotional intelligence & Job performance among the nurses. Material and methods: this study was conducted at Shebin Elkom University Hospital a convenience sample of 143 staff nurses and total number of nurse mangers (20) were recruited from Shebin El Kom University Hospital working in different units and departments, at least having two years of experience. Two tools were used: first tool, structured questionnaire sheet developed by the researchers to assess nurses emotional intelligence and second tool, job performance questionnaire to determine their level of job performance. Results: the main findings of this study revealed that: there is a statistical significant between overall score of job performance & emotional intelligence. The total score of the emotional intelligence of studied nurses were low level, with a mean115.2 ranging 64- 178 while the total score of job performance of studied nurses were a moderate level with a mean 145.8 ranging between 69-199. Conclusion: It was concluded that there was a positive correlation between overall score of job performance & emotional intelligence. Recommendations: several recommendations have been drown in nursing practice, nursing education and nursing research. Emotional intelligence based training program must be held and focus on up to date knowledge, relevant skills and good moral values for nurses and nurse mangers. Educational preparation of nurses by incorporating emotional intelligence lessons into the nursing curricula for graduate and undergraduate, and further nursing research is needed to explore the model of emotional intelligence which is most appropriate for nursing practices. (Manal Mohamed Bakr and Sanaa M. Safaan. Emotional Intelligence: A Key for Nurses' Performance. J Am Sci 2012;8(11):385-393). (ISSN: 1545-1003). http://www.jofamericanscience. org. 59
Highly automated computer-aided diagnosis of neurological disorders using functional brain imaging

We have implemented a highly automated analytical method for computer aided diagnosis (CAD) of neurological disorders using functional brain imaging that is based on the Scaled Subprofile Model (SSM). Accurate diagnosis of functional brain disorders such as Parkinson's disease is often difficult clinically, particularly in early stages. Using principal component analysis (PCA) in conjunction with SSM on brain images of patients and normals, we can identify characteristic abnormal network covariance patterns which provide a subject dependent scalar score that not only discriminates a particular disease but also correlates with independent measures of disease severity. These patterns represent disease-specific brain networks that have been shown to be highly reproducible in distinct groups of patients. Topographic Profile Rating (TPR) is a reverse SSM computational algorithm that can be used to determine subject scores for new patients on a prospective basis. In our implementation, reference values for a full range of patients and controls are automatically accessed for comparison. We also implemented an automated recalibration step to produce reference scores for images generated in a different imaging environment from that used in the initial network derivation. New subjects under the same setting can then be evaluated individually and a simple report is generated indicating the subject's classification. For scores near the normal limits, additional criteria are used to make a definitive diagnosis. With further refinement, automated TPR can be used to efficiently assess disease severity, monitor disease progression and evaluate treatment efficacy.
A multi-theoretical perspective on IS security behaviors

Increasingly, organizations and individuals rely upon technologies and networks more and more. Likewise, these environments are infested with more dangers, which could be avoided if computer users were to follow general security guidelines or procedures. Despite the ever-increasing threat, little research has addressed or explained why individuals purposefully engage in behaviors that make them more vulnerable to these threats, rather than avoiding or protecting themselves from such threats. Despite the advantage that could be afforded by understanding the motivations behind such behaviors, research addressing these behaviors is lacking or focused on very specific theoretical bases. This dissertation addresses this research gap by focusing on security-related behaviors that have yet to be addressed in this research stream, and by using novel theoretical perspectives that increase our insight into these types of behaviors. Four studies (n = 1,430) are tested and reported here that support the four behaviors and theoretical perspectives that are of focus in this dissertation. By considering additional theories, constructs, and theoretical perspectives, this dissertation provides several important contributions to security-related behaviors. The results of this study provide new insights into the motivations behind the purposeful enactment of behaviors that increase one’s vulnerability to technological threats and risks.
Recent advances in bioreactors for cell-based therapies

Bioreactors have become indispensable tools in the cell-based therapy industry. Various forms of bioreactors are used to maintain well-controlled microenvironments to regulate cell growth, differentiation, and tissue development. They are essential for providing standardized, reproducible cell-based products for regenerative medicine applications or to establish physiologically relevant in vitro models for testing of pharmacologic agents. In this review, we discuss three main classes of bioreactors: cell expansion bioreactors, tissue engineering bioreactors, and lab-on-a-chip systems. We briefly examine the factors driving concerted research endeavors in each of these areas and describe the major advancements that have been reported in the last three years. Emerging issues that impact the commercialization and clinical use of bioreactors include (i) the need to scale up to greater cell quantities and larger graft sizes, (ii) simplification of in vivo systems to function without exogenous stem cells or growth factors or both, and (iii) increased control in the manufacture and monitoring of miniaturized systems to better capture complex tissue and organ physiology.
Selective dissociation between LSD1 and GFI1B by a LSD1 inhibitor NCD38 induces the activation of ERG super-enhancer in erythroleukemia cells

Lysine-specific demethylase 1 (LSD1) is a histone modifier for transcriptional repression involved in the regulation of hematopoiesis. We previously reported that a LSD1 inhibitor NCD38 induces transdifferentiation from erythroid lineage to granulomonocytic lineage and exerts anti-leukemia effect through de-repression of the specific super-enhancers of hematopoietic regulators including ERG in a human erythroleukemia cell line, HEL. However, the mechanistic basis for this specificity of NCD38 has remained unclear. Herein, we report major partners associated with LSD1 and clarify the mechanism in HEL cells. Proteome analysis identified 54 candidate proteins associated with LSD1, including several transcription factors such as GFI1B and RUNX1 as well as BRAF-histone deacetylase complex (BHC) components such as CoREST, HDAC1, and HDAC2. NCD38 selectively disrupted the interaction of LSD1 with GFI1B but not with RUNX1, CoREST, HDAC1 and HDAC2. Erg was downregulated in murine erythroid progenitors with prominent upregulation of Gfi1b. NCD38 induced ERG and attenuated an erythroid marker CD235a in HEL while this attenuation was mimicked by the lentiviral overexpression of ERG. The ERG super-enhancer contained the conserved binding motif of GFI1B and was actually occupied by GFI1B. NCD38 dissociated LSD1 and CoREST but not GFI1B from the ERG super-enhancer. Collectively, the selective separation of LSD1 from GFI1B by NCD38 restores the ERG super-enhancer activation and consequently upregulates ERG expression, inducing the transdifferentiation linked to the anti-leukemia effect.
Some Rates are Better than Others

Within the growing literature on goodwill impairment testing under the IFRS framework, the topic of discount rate selection choice by reporting entities has been particularly controversial. Some previous researchers, notably Carlin & Finch (2009) have argued that there is credible evidence to sustain the proposition that a non-trivial number of firms reporting under IFRS have applied indefensibly low discount rates when testing for impairment. Other scholars (for example, Gallery, 2009) have suggested that an insufficient quantity of evidence has accumulated to this point to sustain such a proposition with adequate confidence. This paper contributes to the literature by reviewing an extended data set on discount rate selection choice by ASX-listed firms. It concludes that the incidence of the application of unusual or ‘out of expectations’ discount rates is a continued and persistent feature of the Australian financial reporting landscape and that for a significant number of firms, variations between expected and actual applied discount rates remain material.
Gender Differences in ET and NOS Systems in ETB Receptor-Deficient Rats: Effect of a High Salt Diet

Abstract—The purpose of this study was to determine if rats lacking the ETB receptor have altered renal endothelin (ET) production and NO synthase (NOS) activity in response to high salt and if female rats are better able to control blood pressure through higher NOS activity in rats heterozygous (sl/+) and homozygous (sl/sl) for ETB receptor deficiency. On normal salt (0.4% NaCl; NS), male sl/sl rats had higher systolic blood pressures compared with male sl/+ and female sl/+ and sl/sl rats. On a high salt diet (10% NaCl; HS), blood pressure in male sl/+ rats was significantly higher than female sl/+ rats. However, ETB receptor deficiency caused much larger increases in blood pressure in male and female rats. On NS, urinary ET excretion was not different between male and female of either genotype. HS significantly increased ET excretion in male and female sl/+ rats, but the increase was significantly less in sl/sl compared with sl/+. Homogenates of inner medullary collecting duct tissue were separated into particulate and cytosolic fractions and total NOS activity measured by conversion of [3H]L-arginine to [3H]L-citrulline. Female rats had significantly greater cytosolic NOS activity compared with male rats on NS. On HS, cytosolic NOS activity was lower in all groups compared with NS rats, whereas particulate NOS activity was significantly greater in male and female sl/+ rats compared with male and female sl/sl rats. These data support our hypothesis that NOS protects against rises in blood pressure in female rats and ETB receptors prevent further increases in blood pressure due to increases in renal ET production and NOS activity.
The Association of Household Food Insecurity and the Risk of Calcium Oxalate Stones.

PURPOSE Food insecurity has been defined as 'limited or uncertain availability of nutritionally adequate and safe foods', which associated with adverse health consequences in human. Another alarming condition, which is related to several comorbidities is kidney stone. This study aimed to determine the association of household food insecurity and developing kidney stones (calcium oxalate) in adults referred to medical centers of Babol. MATERIALS AND METHODS This case-control study included 200 participants 18-65 years of ages (100 cases, 100 controls). An 18-items food insecurity questionnaire (USDA), a valid and reliable 147-item food frequency questionnaire (FFQ) and demographic characteristics were obtained via interviewing. RESULTS Sixty eight percent of cases and 40% of controls were food insecure, respectively. Food insecurity was significantly associated with the risk of kidney stone (P < .05). Furthermore, body mass index (BMI) and family history of kidney stone were significantly associated with the risk of kidney stones (P < .05). CONCLUSION Food insecurity and BMI were significantly associated with the kidney stone, which shows the importance of availability of nutritionally adequate and safe foods in prevention of the kidney stone.
Tailoring structure and technological properties of plant proteins using high hydrostatic pressure

ABSTRACT The demand for proteins is rising and alternatives to meat proteins are necessary since animal husbandry is expensive and intensive to the environment. Plant proteins appear as an alternative; however, their techno-functional properties need improvement. High-pressure processing (HPP) is a non-thermal technology that has several applications including the modification of proteins. The application of pressure allows modifying proteins' structure hence allowing to change several of their properties, such as hydration, hydrophobicity, and hydrophilicity. These properties may influence the solubility of proteins and their ability to stabilize emulsions or foams, create aggregates or gels, and their general role in stability and texture of food commodities. Commonly HPP decreases the proteins' solubility yet increasing their surface hydrophobicity exposing sulfhydryl groups, which promotes aggregation or gelation or enhance their ability to stabilize emulsions/foams. However, these effects are not verifiable for all the proteins and are immensely dependent on the type and concentration of the protein, environmental conditions (pH, ionic strength, and co-solutes), and HPP conditions. This review collects and critically discusses the available information on how HPP affects the structure of plant proteins and how their techno-functional properties can be tailored using this approach.
Associações de foraminíferos e composição textural da região próxima ao emissário submarino de esgotos domésticos de Cigarras, Canal de São Sebastião, SP, Brasil

O objetivo do presente estudo foi caracterizar por meio da integracao de estudos da composicao textural e das associacoes de foraminiferos a regiao proxima ao emissario submarino de esgotos domesticos de Cigarras, localizado no Canal de Sao Sebastiao, municipio de Sao Sebastiao, Sao Paulo, Brasil. A malha de amostragem, com 10 estacoes, foi posicionada em regiao circunjacente aos difusores do emissario submarino. Foram realizadas analises granulometricas, do conteudo de materia orgânica e das associacoes de foraminiferos. Os resultados das analises granulometricas e analises tafonomicas e morfometricas realizadas nas carapacas dos foraminiferos (tanatocenoses) indicam que a area de estudo e ambiente de fraco hidrodinamismo, o que possibilita a deposicao de elevada concentracao de materia orgânica. As baixas riquezas, diversidades especificas e equitabilidades, observadas nas biocenoses, sao indicativas de estresse ambiental, o qual pode ser associado ao enriquecimento orgânico que ha na regiao. Ammonia tepida e a especie predominante em todas as estacoes analisadas.
Adapting population models for application in pesticide risk assessment: A case study with Mead's milkweed

Population models can facilitate assessment of potential impacts of pesticides on populations or species rather than individuals and have been identified as important tools for pesticide risk assessment of nontarget species including those listed under the Endangered Species Act. Few examples of population models developed for this specific purpose are available; however, population models are commonly used in conservation science as a tool to project the viability of populations and the long‐term outcomes of management actions. We present a population model for Mead's milkweed (Asclepias meadii), a species listed as threatened under the Endangered Species Act throughout its range across the Midwestern United States. We adapted a published population model based on demographic field data for application in pesticide risk assessment. Exposure and effects were modeled as reductions of sets of vital rates in the transition matrices, simulating both lethal and sublethal effects of herbicides. Two herbicides, atrazine and mesotrione, were used as case study examples to evaluate a range of assumptions about potential exposure–effects relationships. In addition, we assessed buffers (i.e., setback distances of herbicide spray applications from the simulated habitat) as hypothetical mitigation scenarios and evaluated their influence on population‐level effects in the model. The model results suggest that buffers can be effective at reducing risk from herbicide drift to plant populations. These case studies demonstrate that existing population models can be adopted and integrated with exposure and effects information for use in pesticide risk assessment. Environ Toxicol Chem 2018;37:2235–2245. © 2018 SETAC
Recrystallization of Drugs: Significance on Pharmaceutical Processing

Not surprisingly, the wide range of effective medicinal agents available today is one of the greatest scientific achievements. Regardless of the advancements in effectiveness and safety of the medicines embedded in dosage forms, the pharmaceutical concept of the latter is growing to be ever more eminent (Adibkia et al., 2011). Following on from recent advancements, in a time of increased considerations to the level of sophistication in designing pharmaceutical dosage forms keeping pace with advances in drug discovery methods, it seems as important as ever to study the physicochemical properties of active pharmaceutical ingredients, prerequisite for a successful product formulation.
Ipsilesional Nystagmus Induced by Vibration in Subjects With Ménière's Disease or Vestibular Schwannoma.

OBJECTIVE To analyze the frequency in which vibration-induced nystagmus (VIN) with ipsilesional direction appears in subjects with Ménière's disease (MD) or vestibular schwannoma (VS). STUDY DESIGN Cross-sectional study. SETTING Tertiary referral center. PATIENTS Fifty-two subjects with MD and 21 subjects with vestibular schwannoma. INTERVENTION Videonystagmographic recordings of VIN at 30, 60, and 100 Hz. MAIN OUTCOME MEASURES Direction and slow phase velocity of VIN at 30, 60, and 100 Hz. RESULTS Ipsilesional Nystagmus was observed in 8 of 52 subjects with MD (15.4%) and in 11 of 21 subjects affected of unilateral VS (52.4%). Ipsilesional nystagmus was significantly higher in patients with VS (p = 0.003). The frequency of appearance of ipsilesional nystagmus in the subjects with VS who has not been treated was significantly higher than those who underwent radiosurgery (84.6% vs 0%, p = 0.046). CONCLUSION Ipsilesional vibration-induced Nystagmus can be present in subjects with vestibular deficits caused by MD and VS.
Routine repeat head CT may not be necessary for patients with mild TBI

Background Routine repeat cranial CT (RHCT) is standard of care for CT-verified traumatic brain injury (TBI). Despite mixed evidence, those with mild TBI are subject to radiation and expense from serial CT scans. Thus, we investigated the necessity and utility of RHCT for patients with mild TBI. We hypothesized that repeat head CT in these patients would not alter patient care or outcomes. Methods We retrospectively studied patients suffering from mild TBI (Glasgow Coma Scale (GCS) score 13–15) and treated at the R Adams Cowley Shock Trauma Center from November 2014 through January 2015. The primary outcome was the need for surgical intervention. Outcomes were compared using paired Student’s t-test, and stratified by injury on initial CT, GCS change, demographics, and presenting vital signs (mean ± SD). Results Eighty-five patients met inclusion criteria with an average initial GCS score=14.6±0.57. Our center sees about 2800 patients with TBI per year, or about 230 per month. This includes patients with concussions. This sample represents about 30% of patients with TBI seen during the study period. Ten patients required operation (four based on initial CT and others for worsening GCS, headaches, large unresolving injury). There was progression of injury on repeat CT scan in only two patients that required operation, and this accompanied clinical deterioration. The mean brain Abbreviated Injury Scale (AIS) score was 4.8±0.3 for surgical patients on initial CT scan compared with 3.4±0.6 (P<0.001) for non-surgical patients. Initial CT subdural hematoma size was 1.1±0.6 cm for surgical patients compared with 0.49±0.3 cm (P=0.05) for non-surgical patients. There was no significant difference between intervention groups in terms of other intracranial injuries, demographics, vital signs, or change in GCS. Overall, 75 patients that did not require surgical intervention received RHCT. At $340 per CT, $51 000 was spent on unnecessary imaging ($367 000/year, extrapolated). Discussion In an environment of increased scrutiny on healthcare expenditures, it is necessary to question dogma and eliminate unnecessary cost. Our data questions the use of routine repeat head CT scans in every patient with anatomic TBI and suggests that clinically stable patients with small injury can simply be followed clinically. Level of evidence Level III.
A p57 conditional mutant allele that allows tracking of p57‐expressing cells

p57Kip2 (p57) is a maternally expressed imprinted gene regulating growth arrest which belongs to the CIP/KIP family of cyclin‐dependent kinase inhibitors. While initially identified as a cell cycle arrest protein through inhibition of cyclin and cyclin‐dependent kinase complexes, p57 activity has also been linked to differentiation, apoptosis, and senescence. In addition, p57 has recently been shown to be involved in tumorigenesis and cell fate decisions in stem cells. Yet, p57 function in adult tissues remains poorly characterized due to the perinatal lethality of p57 knock‐out mice. To analyze p57 tissue‐specific activity, we generated a conditional mouse line (p57FL‐ILZ/+) by flanking the coding exons 2–3 by LoxP sites. To track p57‐expressing or mutant cells, the p57FL‐ILZ allele also contains an IRES‐linked β‐galactosidase reporter inserted in the 3′ UTR of the gene. Here, we show that the β‐galactosidase reporter expression pattern recapitulates p57 tissue specificity during development and in postnatal mice. Furthermore, we crossed the p57FL‐ILZ/+ mice with PGK‐Cre mice to generate p57cKO‐ILZ/+ animals with ubiquitous loss of p57. p57cKO‐ILZ/+ mice display developmental phenotypes analogous to previously described p57 knock‐outs. Thus, p57FL‐ILZ/+ is a new genetic tool allowing expression and functional conditional analyses of p57.
Discriminatory Property Inheritance Rights Under The Yoruba And Igbo Customary Law In Nigeria: The Need For Reforms *

Intestate succession under customary law among the Yoruba and Igbo people in Nigeria is full of discrimination, especially to female, adopted child, illegitimate child among others. This paper highlights some of these forms of discrimination and the dangers inherent in them. The paper discovers that some of these forms of discrimination are against Fundamental Human Rights which frown against discrimination to any persons irrespective of their gender, circumstances of birth or age. The paper suggests necessary reforms to curb some of these identified discrimination.