Miracle-dz/UniFAR-FTUs huggingface dataset:
Discovery of predictive biomarker candidates for intrinsic resistance to FOLFOX chemotherapy in colon cancer using a Top Down LC-MALDI approach -

Colorectal cancer is the third most commonly diagnosed cancer in males and the second in females, with over 1.2 million new cancer cases and 608,700 cancer related deaths in 2008 [1]. Despite the advances being made in early detection of colorectal cancer, approximately half of all patients develop metastatic disease [2]. The prognosis for these patients is poor, although palliative chemotherapy has been shown to be able to prolong survival and to improve the quality of life compared with the best supportive care [3]. Chemoresistance of cancer cells to chemotherapeutics is a main obstacle in chemotherapy to a successful outcome in first line therapy. It has been hypothesized that selection pressure resulting from tumor internal evolution can lead to subpopulations of cell clones, carrying certain cellular mechanism that can be summarized under the term “intrinsic chemoresistance. ” Cellular mechanisms of intrinsic chemo resistance are mainly characterized by the fact that they lead to increased tolerance of cancer cells to chemotherapeutics. These cells are most likely to survive first line chemotherapy and arise as recurrence disease.
Is Busy Really Busy? Board Governance Revisited

We investigate the relationship between firm governance and the board's position in the social network of directors. Using a sample of 133 German firms over the four-year period from 2003 to 2006, we find that firms with intensely connected supervisory boards are (1) associated with lower firm performance, and (2) pay their executives significantly more. We interpret these results as evidence of poor monitoring in firms with directors who are more embedded in the social network. In both cases, simple measures for busy directors that were used by other studies in the past fail to show any significant pattern. The findings suggest that the quality and structural position of additional board seats may play a bigger role than simply the number of board appointments.
Control of Human Body Movement by Neural Mismatch Model

Human posture control is maintained by proprioceptive, vestibular and visual feedback integrated within the central vestibular and locomotor system. Lesions to the sensory feedback system, or to the central nervous system, may impair postural control and equilibrium. It is therefore of interest to assess the ability of postural control by measuring the displacement of the body center of gravity. Recordings of the amplitude and frequency of spontaneous oscillations around the equilibrium position may describe the sway and thus the control of posture. [DOI:10.12866/J.PIVAA. 2013.09. 002]1
Detecting Deceptive Impression Management Behaviors in Interviews Using Natural Language Processing

DETECTING DECEPTIVE IMPRESSION MANAGEMENT BEHAVIORS IN INTERVIEWS USING NATURAL LANGUAGE PROCESSING Elena Margaret Lawrence Auer Old Dominion University, 2018 Director: Dr. Richard N. Landers Deceptive impression management (IM) is often used by applicants in employment interviews to improve their chances of receiving a job offer. Self-report measures of deceptive IM are typically used to evaluate interview faking in a lab setting but are limited when used in practice due to social desirability concerns. Given this limitation, natural language processing (NLP) has potential as a tool to unobtrusively assess raw interview content and measure deceptive IM. This study examined the use of open and closed-vocabulary NLP approaches for the detection of deceptive IM in mock employment interviews. In general, neither of these approaches successfully predicted deceptive IM. Several possible conclusions based on these findings are discussed. However, given the lack of empirical support for this method, organizations should proceed with caution when deciding to use NLP techniques to predict deceptive IM in employment interviews.
The capital structure choice: Evidence of debt maturity substitution by GCC firms

The objective of this study is to investigate the determinants of the capital structure decision in the face of restricted access to external financing. Based on a sample of 150 listed firms over the period 2000-2009, a two-stage least squares regression is used to test the determinants of capital structure, while controlling for firm-specific and country-specific factors. The results show that size, profitability, tax-shield and collateral have a significant impact on leverage. A country effect is also observed. Firms operating in the United Arab Emirates (UAE) exhibit a significantly higher level of leverage when compared to their peers in the neighboring countries. The results further document a novel finding that highlights the practice of debt-maturity substitution to circumvent the existence of external financing constraints faced by firms operating in the Gulf Cooperation Council (GCC) region.
Effect of Particle Size on Properties of Sidoarjo Mud-Based Geopolymer

The eruption of Sidoarjo mud volcano that has been taken place since 2006 had caused significant damage to the local social environment, and until now there is no immediate solution that can be offered. Utilization of the Sidoarjo mud as construction material recently has gained some advancement by calcination of the mud, that make the previously inert material to become more reactive and to be more viable for its use as cement replacement or geopolymer precursor. This paper reports an on-going study to utilize the Sidoarjo mud as precursor of geopolymer by investigating the influence of particle size on the reactivity of the calcined Sidoarjo mud. Furthermore, durability properties of Sidoarjo mud-based geopolymer was also studied. The results show that making finer the mud particles by milling in longer period, using a rod-mill drum for 8 hours, can increase the reactivity of the mud. Compressive strength of geopolymer mortar can increase up to 155% when compared to the ones based on milling time of only 2 hours. Durability properties of sulphate acid resistance and chloride penetration are comparable to fly ash-based geopolymer, while the shrinkage measurement showing higher value.
Student Perceptions of Lecturer Classroom Communication Style

The way a teacher communicates in the classroom is studied from the perspective of the university student. The sample consisted of students enrolled in a programme at a university that follows a blended learning system making use of a resource rich learning environment of lectures, tutorials, and online resources. Adult learners on Masters’ programmes in Computing Science attending teacher led lectures in several locations (e.g., London, Hong Kong, Shenzhen) completed questionnaires describing five communication patterns. They are (a) challenging, (b) encouragement and praise, (c) non-verbal support, (d) understanding and friendly, and (e) controlling communication. Results of the data indicate that students rate communication patterns in significantly different ways. There were statistically significant relationships between both challenging and controlling communication and final course grades; challenging and encouragement/praise communication patterns were significant when data were analysed by cultural background such that Eastern and Western students rated the same teachers as having different communication patterns; there were significant differences on all five communication styles by gender. Findings indicate that teachers need to be aware of their communication style as it has differential effects for their students by their gender and culture, and may in some cases more significantly impact upon student’s final grades.
Specialty area : RE Course : Added Value of DWI for Your Clinical Practice Renal Lesions : Added Value of Diffusion MRI

Background and motivation: Conventional CT and MRI are limited in their ability to differentiate renal lesions. DWI provides additional functional information over conventional imaging which lends insight into tissue diffusion and perfusion characteristics on a microstructural level, helping to differentiate renal cysts and abscesses from cystic RCC, solid benign from solid malignant lesions, and between RCC subtypes. The purpose of this talk is to demonstrate the use of DWI in improving characterization of renal lesions (1).
Hidden Tales of the Bujang Valley Maznah

Legends thrive, but there is little tangible evidence about dozens of Malay kingdoms, which are said to have flourished long before the emergence of Melaka in the late 14 century. The Bujang Valley in South Kedah, for one, is Malaysia’s richest archaeological site. The valley is the guardian of countless hidden tales which are waiting to be unveiled. Here, the beliefs of the Malay ancestors were centred upon nature and the spirits which permeate every aspect of their lives. These beliefs have been passed down to the next generation by the elderly. They have valuable information to share about their families and ethnicity of which written evidence is often scarce. Such tales may perish if they are not well documented. Oral history, adopted as its testimony, permits us to gather data not available in written records. Oral history techniques are able to elicit facts, feelings, and descriptions, contributing to social history. Moreover, this technique is able to reveal how individual values and actions shaped the past, and how the past shapes present-day values and actions. Findings include offerings made to appease the spirits of the rivers and lands. Other findings include the revelation of the Bujang Valley as the centre of knowledge. The establishment of madrasah – “sekolah pondok” brought about a better understanding of Islam resulting in the inherent beliefs in the supernatural to slowly diminish. All these recollections form a body of knowledge that is priceless and worth recording. Knowledge published in tangible forms is a key factor to worldwide recognition. Therefore, these efforts to safeguard oral history and family stories should be a top priority for new knowledge development and commercial enhancement for generations to come.
ÖRGÜTSEL KÜLTÜRÜN ÜRÜN İNOVASYONU ÜZERİNDE ETKİSİNE YÖNELİK BİR ARAŞTIRMA

Kuresel ve yerel pazarlarda yasanan yogun rekabet ortaminda orgutler, karliliklarini korumak ve artirmak amaciyla yeni urunleri, yol ve yontemleri kullanmak zorunda kalmaktadir. Bu durum orgutlerin inovasyon ve urun inovasyonu faaliyetlerini tesvik etmektedir. Orgutlerde inovasyon ve urun inovasyonu calismalarini etkileyen ic ve dis cevre faktorleri bulunmaktadir. Bu ic cevre faktorlerinden birisinin de orgutsel kultur oldugu dusunulmektedir. Bu calisma, orgutsel kulturun urun inovasyonu uzerinde bir etkisinin olup/olmadigini bulabilmek amaciyla yapilmistir. Bu baglamda orgutsel kulturun boyutlari olan vizyonun, ise katilimin, uyumun ve tutarliliginin urun inovasyonu uzerindeki etkisi degerlendirilmistir. Arastirma verisi, Gaziantep 1. , 3. , ve 4. organize sanayi bolgelerinde faaliyette bulunan isletme yoneticilerinden toplanmistir. Verinin toplanmasinda anket yontemi kullanilmistir. Toplam 245 anket degerlendirilmis olup, verinin degerlendirilmesinde frekans dagilimlari ve coklu dogrusal regresyon analizlerinden yararlanilmistir. Sonuc olarak vizyon ve ise katilim boyutlarinin urun inovasyonu uzerinde anlamli bir etkiye sahip oldugu bulunmustur. Ancak uyum ve tutarlilik boyutlarinin urun inovasyonu uzerinde anlamli bir etkisinin bulunmadigi saptanmistir.
Variational characterization of the critical curve for pinning of random polymers

In this paper we look at the pinning of a directed polymer by a one-dimensional linear interface carrying random charges. There are two phases, localized and delocalized, depending on the inverse temperature and on the disorder bias. Using quenched and annealed large deviation principles for the empirical process of words drawn from a random letter sequence according to a random renewal process (Birkner, Greven and den Hollander [6]), we derive variational formulas for the quenched, respectively, annealed critical curve separating the two phases. These variational formulas are used to obtain a necessary and sufficient criterion, stated in terms of relative entropies, for the two critical curves to be different at a given inverse temperature, a property referred to as relevance of the disorder. This criterion in turn is used to show that the regimes of relevant and irrelevant disorder are separated by a unique inverse critical temperature. Subsequently, upper and lower bounds are derived for the inverse critical temperature, from which sufficient conditions under which it is strictly positive, respectively, finite are obtained. The former condition is believed to be necessary as well, a problem that we will address in a forthcoming paper. Random pinning has been studied extensively in the literature. The present paper opens up a window with a variational view. Our variational formulas for the quenched and the annealed critical curve are new and provide valuable insight into the nature of the phase transition. Our results on the inverse critical temperature drawn from these variational formulas are not new, but they offer an alternative approach that is flexible enough to be extended to other models of random polymers with disorder.
INNOVATION STRATEGY, WORKING CLIMATE, AND FINANCIAL PERFORMANCE IN TRADITIONAL MANUFACTURING FIRMS: AN EMPIRICAL ANALYSIS

In this study, we address the effect of innovation strategy and an innovative working climate on financial performance in the Norwegian wood industry. Innovation strategy embodies four dimensions: the degrees to which innovation in the form of products, processes, and business systems are embedded in the management values and priorities as well as the degree of expenditure in R&D. An innovative working climate is exemplified by team cohesion, supervisory encouragement, resources, autonomy, challenge, and openness to innovation. Previous studies have indicated a lack of research in traditional manufacturing firms on both innovation strategy and a supportive working climate. Our survey was answered by 241 CEOs. The connectional model was tested with structural equation modelling, and all hypotheses received support. This result implied that innovation strategy and an innovative working climate enhanced financial performance in traditional manufacturing firms.
Some instability puzzles in Kaleckian models of growth and distribution: A critical survey

We tackle the issue of the possible instability of the Kaleckian distribution and growth model. Distinguishing between Keynesian and Harrodian instability, we review various mechanisms that have been proposed by critics of the Kaleckian model to tame Harrodian instability while bringing back the rate of utilisation to its normal rate. We find that the mechanisms that have been suggested are far from convincing. Therefore, we conclude that it may be premature for the critics of the Kaleckian model to dismiss the endogeneity of the rate of capacity utilisation in long-run growth equilibrium. Copyright The Author 2010. Published by Oxford University Press on behalf of the Cambridge Political Economy Society. All rights reserved. , Oxford University Press.
لاسل تيريطلا ةرطفتملا هع ثاساردلتيرصملا نابللأا عرازم ضعب هم تلوزعملا لسلا ريظو ت رلا دبعشيىغملا دبع يحتف دي ، يملح دمحم ىوشو ،هفرع راتسلا دبع

Received at: 17/6/2015 Accepted: 28/7/2015 The current study was carried out on three Egyptian dairy herds located at Alexandria, Ismailia and Mansoura, from 2009 to 2012. Those herds were suffering from clinical or subclinical infection of Mycobacterium avium subspecies paratuberculosis (MAP). The objective from this work is to identify circulating strains in some Egyptian dairy herds. Animals were tested for detection of anti Mycobacterium paratuberculosis antibodies by ELISA test. Animal fecal samples were cultured on Herrold’s egg yolk medium (HEYM) supplemented with mycobactin-J. The confirmed positive results used for isolation of ―MAP‖ from 11 out of 23 samples. Moreover, results of real timePCR specific for IS900 gene of M. paratuberculosis on 23 fecal samples indicated the positivity of 21 fecal samples. Five bacterial isolates (two from Alexandria, two from Ismailia and one from Mansoura) were subjected to conventional PCR targeting a 413-bp fragment of the IS900. The 413 bp PCR purified product were subjected to sequencing. The obtained sequences were aligned and compared to other international strains of MAP using Basic Local Aligment Search Tool (BLAST). The sequencing data shows that 3 isolates were identical to each other (100%) and to other strains from Europe (UK, Spain, Netherlands, Slovakia, Germany and Italy); the other 2 isolates show 98% similarity. Authors recommended that establishment of strict measures for mycobacterium avium subspecies paratuberculosis infections by the Egyptian authorities is very important.
Evaluating Chemical Interaction Studies for Mixture Risk Assessment

We describe a set of criteria to evaluate the quality of data and interpretations in chemical interaction studies. These criteria reflect the consensus of the literature on interaction analysis developed over decades of research in pharmacology, toxicology, and biometry; address common pitfalls in published interaction studies; and can be easily applied to common methods of interaction analysis. The criteria apply broadly to interaction data for drugs, pesticides, industrial chemicals, food additives, and natural products and are intended to assist risk assessors who must evaluate interaction studies for use in component-based mixture risk assessments. The criteria may also assist researchers interested in conducting interaction studies to inform mixture risk assessment. The criteria are also intended to serve larger scientific goals, including increasing the repeatability of results obtained in chemical interaction studies, enhancing the reliability of conclusions drawn from interaction data, providing greater consistency of interpretations among various analysts, and decreasing uncertainty in using interaction data in risk assessments. We describe the basis for each criterion and demonstrate their utility by using them to evaluate interaction studies from the recent toxicological and pharmacological literature, which serve as examples of different types of data sets that the risk assessor may encounter.
Combined constraints on deviations of dark energy from an ideal fluid from Euclid and Planck

Cosmological fluids are commonly assumed to be distributed in a spatially homogeneous way, while their internal properties are described by a perfect fluid. As such, they influence the Hubble-expansion through their respective densities and equation of state parameters. The subject of this paper is an investigation of the fluid-mechanical properties of a dark energy fluid, which is characterised by its sound speed and its viscosity apart from its equation of state. In particular, we compute the predicted spectra for the integrated Sachs-Wolfe effect for our generalised fluid, and compare them with the corresponding predictions for weak gravitational lensing and galaxy clustering, which had been computed in previous work. We perform statistical forecasts and show that the integrated Sachs-Wolfe signal obtained by cross correlating Euclid galaxies with Planck temperatures, when joined to galaxy clustering and weak lensing observations, yields a percent sensitivity on the dark energy sound speed and viscosity. We prove that the iSW effect provides strong degeneracy breaking for low sound speeds and large differences between the sound speed and viscosity parameters.
Burnout Syndrome in Mental Health Professionals: psychiatric hospital setting

Correspondence to: Tihana Jendričko University Psychiatric Hospital Vrapče, Bolnička cesta 32, Zagreb, Croatia e mail: tjendricko@gmail.com Copyright © 2017 KBCSM, Zagreb e-mail: alcoholism.kbcsm@gmail.com • www.http//hrcak.srce. hr/acoholism Abstract Burnout is frequently mentioned as a problem in the mental health field. As a type of prolonged response to chronic job-related stressors, has a special significance in health care where staff experience both psychological-emotional and physical stress. The aim of the paper was to determine the level of stress in professionals working in psychiatric hospital, as well as to explore possible differences in stress level regarding the different characteristic of participants as sex, level of education, marital status, working hours etc. The Burnout Clinical Subtypes Questionnaire was used. Study was conducted from July to December 2014, and from April to May 2015. The sample of 141 participants who work in mental health profession consists of 39.9% male and 68.1% female, average age of 38.98 years. Overall results show that participants have lower scores on all subscales. The results showed that there is moderate burnout experience in the sense that participants feel overload when they try to maximize their reward by taking on a volume and pace of work that become excessive. This questionnaire can be a very useful instrument for future evaluation and designing interventions and different treatment strategies for subtypes of burnout.
Learning While Using an Instructional Simulation

LEARNING WHILE USING AN INSTRUCTIONAL SIMULATION Tayyaba Batool Old Dominion University, 2017 Director: Dr. Ginger S. Watson Learner control is thought to be valuable by some scholars who believe that it allows learners to adapt instructions to their needs while reducing cognitive load (Mayer & Moreno, 2003). Although learner control offers some advantages to the learner, the importance of an instructor cannot be denied. In instructor-controlled settings the instructor provides guidance to the learners. Direct instructional guidance provides information to the learner that explains the concepts and procedures that are to be learned along with the instructional strategy support that is compatible with human cognitive architecture (Kirschner, Sweller, & Clark, 2006). This study compared the effects of learner-controlled simulation to instructor-guided presentation of an instructional simulation. Outcome variables were achievement, cognitive load, time-on-task, instructional efficiency, perceptions of learner control, and attitude for future use. Results of the study indicated no significant differences between the learner-controlled and instructor-guided treatments for achievement, cognitive load, or instructional efficiency. A significant difference was found between the treatments for time-on-task and the perception of learner control where participants in the learner-controlled group spent significantly less time completing the instruction and reported significantly higher learner-control than those in the instructor guidance with activity group.
Quantum Theory is a Quasi-stochastic Process Theory

There is a long history of representing a quantum state using a quasi-probability distribution: a distribution allowing negative values. In this paper we extend such representations to deal with quantum channels. The result is a convex, strongly monoidal, functorial embedding of the category of trace preserving completely positive maps into the category of quasi-stochastic matrices. This establishes quantum theory as a subcategory of quasi-stochastic processes. Such an embedding is induced by a choice of minimal informationally complete POVM's. We show that any two such embeddings are naturally isomorphic. The embedding preserves the dagger structure of the categories if and only if the POVM's are symmetric, giving a new use of SIC-POVM's, objects that are of foundational interest in the QBism community. We also study general convex embeddings of quantum theory and prove a dichotomy that such an embedding is either trivial or faithful.