Miracle-dz/UniFAR-FTUs huggingface dataset:
The urokinase plasminogen activation system in gastroesophageal cancer: A systematic review and meta-analysis

Background The urokinase plasminogen activation (uPA) system is a crucial pathway for tumour invasion and establishment of metastasis. Although there is good evidence that uPA system expression is a clinically relevant biomarker in some solid tumours, its role in gastroesophageal cancer is uncertain. Results We identified 22 studies encompassing 1966 patients which fulfilled the inclusion criteria. uPA, uPAR, or PAI-1 expression is significantly associated with high risk clinicopathological features. High uPA expression is associated with a shorter RFS (HR 1.90 95% 1.16–3.11, p = 0.01) and OS (HR 2.21 95% CI 1.74–2.80, p < 0.0001). High uPAR expression is associated with poorer OS (HR 2.21 95%CI 1.82–2.69, p < 0.0001). High PAI-1 expression is associated with shorter RFS (HR 1.96 96% CI 1.07–3.58, p = 0.03) and OS (HR 1.84 95%CI 1.28–2.64, p < 0.0001). There was no significant association between PAI-2 expression and OS (HR 0.97 95%CI 0.48–1.94, p < 0.92) although data was limited. Materials and Methods We undertook a systematic review evaluating expression of uPA, urokinase plasminogen activator receptor (uPAR), plasminogen activator inhibitor-1 (PAI-1/SerpinE1) and plasminogen activator inhibitor-2 (PAI-2/SerpinB2) on primary oesophageal, gastro-oesophageal junction, and gastric adenocarcinomas. We performed a meta-analysis of clinicopathological associations, overall survival (OS) and recurrence free survival (RFS). Conclusions We conclude that the uPA system is a clinically relevant biomarker in primary gastroesophageal cancer, with higher expression of uPA, uPAR and PAI-1 associated with higher risk disease and poorer prognosis. This also highlights the potential utility of the uPA system as a therapeutic target for improved treatment strategies.
Clinical Implications of Lymph Node Micrometastases in Patients with Colorectal Cancers

There is no unanimity about the prognostic significance of lymph node micrometastases from colorectal cancer. A case-control study of patients with recurrent and nonrecurrent colorectal cancer who were closely matched for the Dukes stage, extent of lymph node dissection, tumor size, tumor location, number of resected lymph nodes, age and gender was performed. The presence of micrometastases in a total of 1,633 lymph nodes from 44 patients (22 with and 22 without recurrence) were examined by immunohistochemistry using antibodies for cytokeratin (KL-1) and p53 (RSP53). Immunostaining with KL-1 revealed micrometastases in 15/22 patients [68%; 82/820 lymph nodes (10%)] and 15/22 patients [68%; 45/813 lymph nodes (6%)] in the recurrent and nonrecurrent groups, respectively. Immunohistochemical analysis, using RSP53, of 18 paired patients with p53-positive primary tumor revealed micrometastases in 4/9 patients [44%; (7/265 lymph nodes (2.6%)] and 4/9 patients [44%; 6/257 lymph nodes (2.3%)] with and without recurrence, respectively. Neither the micrometastatic frequencies of the patients nor the resected lymph nodes of the recurrent and nonrecurrent groups differed significantly. Micrometastases in regional lymph nodes are an interesting phenomenon, but do not influence patients’ prognoses if the involved lymph nodes are removed.
Firm Size, Productivity, and Manager Wages: A Job Assignment Approach

Ability of managers and other nonproduction professionals is key for the productivity of firms. Hence, the assignment of heterogeneous nonproduction workers across firms determines the distribution of productivity. In turn, the transmission of productivity differences into profit differences -- resulting from product market competition -- determines firms' willingness to pay for higher managerial skills. This paper explores the equilibrium assignment of nonproduction workers across ex ante identical firms which results from this interaction between product market and the market for nonproduction skills. The analysis suggests that, typically, large and productive firms coexist with small, low-productivity firms. Consistent with empirical evidence, a skewed distribution of firm size tends to arise. Moreover, the model predicts a positive relationship of firm size to productivity, manager quality, and manager remuneration. Finally, according to comparative-static analysis, higher intensity of product market competition can account for increases in the compensation at the top of the wage distribution.
The Association Between Heel Ultrasound and Hormone Replacement Therapy Is Modulated by a Two‐Locus Vitamin D and Estrogen Receptor Genotype

Evidence supports the role of estrogen deprivation in the process of bone remodeling and increased risk of fracture in postmenopausal women but little is known about the genetic basis of individual differences in response to therapy. In a cross‐sectional study, 425 ambulatory postmenopausal French‐Canadian women from Quebec (age range, 42–85 years old) were genotyped for a common Bsm I polymorphism at the vitamin D receptor (VDR) gene as well as a Pvu II polymorphism in the estrogen receptor (ESR1) gene. Heel ultrasound was determined by right calcaneal quantitative ultrasound (QUS) and results were expressed as an age‐ and‐weight‐adjusted stiffness index (heel SI z score). Our aim was to investigate the interaction between hormone‐replacement therapy (HRT) and receptor genotypes in an effect on heel SI. Notably, a two‐locus genotype (VDR‐bb/ESR‐PP) present in 9.5% of women was responsible for over 30% of the total HRT‐related heel SI difference in the whole sample. Women bearing this combined VDR/ESR1 genotype who received HRT for more than 5 years had a 21% (1.25 SD) greater heel SI (p = 0.002) than those bearing the same genotype but who received HRT for <5 years. This may translate into a 2‐ to 3‐fold difference in the risk of fracture. Although follow‐up studies are needed, our findings suggest that QUS of the heel in postmenopausal women taking HRT is affected by variation in VDR and ESR1 loci, jointly.
International PCAOB Inspections and Earnings Management Transmission within Multinational Business Groups

Does the impact of international Public Company Accounting Oversight Board (PCAOB) inspections extend beyond country borders of inspected auditors? We investigate this question by examining multinational business groups. Following initial PCAOB inspections of accounting firms auditing foreign U.S.-listed global ultimate owners, our findings indicate that their multinational subsidiaries decrease earnings management. Research design choices such as the comparison of treated observations with same country-industry-year control observations and a fixed effects structure that controls for country, industry, year, and group characteristics mitigate concerns of omitted variables. Our paper provides evidence for benefits of international PCAOB inspections over and above the previously documented effects for firms located in the countries of the inspected auditors.
Suppression of ventricular arrhythmias during ischemia-reperfusion by agents inhibiting Ins(1,4,5)P3 release.

BACKGROUND Reperfusion following myocardial ischemia causes a rapid and transient release of inositol (1,4,5)triphosphate [Ins(1,4,5)P3]. The aim of this study was to test whether this increased Ins(1,4,5)P3 release was important for the development of ventricular arrhythmias and whether agents that inhibit this signal transduction pathway, such as aminoglycoside antibiotics, suppress arrhythmias. METHODS AND RESULTS In perfused rat hearts, ventricular tachycardia (VT), ventricular fibrillation (VF), and accumulation of Ins(1,4,5)P3 were measured during early reperfusion. A number of different compounds, including neomycin, gentamicin, streptomycin, spermine, reserpine, and prazosin, were effective in inhibiting the reperfusion-induced Ins(1,4,5)P3 release and the onset of VT and VF in parallel. A strong correlation existed between Ins(1,4,5)P3 content, measured at 2 minutes of reperfusion, and the incidence of reperfusion VT and VF. In addition, intravenous gentamicin suppressed the onset of arrhythmias under ischemic and reperfusion conditions in vivo. CONCLUSIONS Our results are consistent with the view that Ins(1,4,5)P3 release plays a pivotal role in mediating arrhythmias during early reperfusion. Agents inhibiting Ins(1,4,5)P3 release are antiarrhythmic and may have potential use clinically.
Model-Based Event-Triggered Predictive Control for Networked Systems with Data Dropout

This paper proposes a novel structure of networked control systems (NCSs) with communication logic, which incorporates model-based networked control systems (MB-NCSs), predictive control, and an event-triggered communication scheme into a unified framework to consider the bandwidth reduction of the network communications. Within this framework, first an event-triggered communication scheme at the sensor side is introduced to determine whether or not the sensor measurement should be transmitted to the controller through the imperfect forward paths. Second, at the controller, a model of the plant is used to predict future state behavior of the plant, and based on the predicted state between successful transmission instants, a novel predictive event-triggering scheme is proposed to compress the size of the packetized control signals transmitted from the controller side to the actuator side through feedback paths. Finally, a unified model of NCSs is established. Based on this model, a codesign condition of th.
PRINCIPAL COMPONENT ANALYSIS OF SLOAN DIGITAL SKY SURVEY STELLAR SPECTRA

We apply Principal Component Analysis (PCA) to ∼100,000 stellar spectra obtained by the Sloan Digital Sky Survey (SDSS). In order to avoid strong nonlinear variation of spectra with effective temperature, the sample is binned into 0.02 mag wide intervals of the g − r color (−0.20 < g − r < 0.90, roughly corresponding to MK spectral types A3–K3), and PCA is applied independently for each bin. In each color bin, the first four eigenspectra are sufficient to describe the observed spectra within the measurement noise. We discuss correlations of eigencoefficients with metallicity and gravity estimated by the Sloan Extension for Galactic Understanding and Exploration Stellar Parameters Pipeline. The resulting high signal-to-noise mean spectra and the other three eigenspectra are made publicly available. These data can be used to generate high-quality spectra for an arbitrary combination of effective temperature, metallicity, and gravity within the parameter space probed by the SDSS. The SDSS stellar spectroscopic database and the PCA results presented here offer a convenient method to classify new spectra, to search for unusual spectra, to train various spectral classification methods, and to synthesize accurate colors in arbitrary optical bandpasses.
Modeling Computer Interest in Older Adults: The Role of Age, Education, Computer Knowledge, and Computer Anxiety

We proposed a mediation model to examine the effects of age, education, computer knowledge, and computer anxiety on computer interest in older adults. We hypothesized that computer knowledge and computer anxiety would fully mediate the effects of age and education on computer interest. A sample of 330 older adults from local senior-citizen apartment buildings completed a survey that included an assessment of the constructs included in the model. Using structural equation modeling, we found that the results supported the hypothesized mediation model. In particular, the effect of computer knowledge operated on computer interest through computer anxiety. The effect of age was not fully mitigated by the other model variables, indicating the need for future research that identifies and models other correlates of age and computer interest. The most immediate application of this research is the finding that a simple 3-item instrument can be used to assess computer interest in older populations. This will help professionals plan and implement computer services in public-access settings for older adults. An additional application of this research is the information it provides for training program designers.
Bifurcation of Limit Cycles from a Fold-Fold Singularity in Planar Switched Systems

An anti-lock braking system (ABS) is the primary motivation for this research. The ABS controller switches the actions of charging and discharging valves in the hydraulic actuator of the brake cylinder based on the wheels' angular speed and acceleration. The controller is, therefore, modeled by discontinuous differential equations where two smooth vector fields are separated by a switching manifold S. The goal of the controller is to maximize the tire-road friction force during braking (and, in particular, to prevent the wheel lock-up). Since the optimal slip L of the wheel is known rather approximately, the actual goal of the controller is to achieve such a switching strategy that makes the dynamics converging to a limit cycle surrounding the region of prospective values of L. In this paper we show that the required limit cycle can be obtained as a bifurcation from a point x0 of S when a suitable parameter D crosses 0. The point x0 turns out to be a fold-fold singularity (the vector fields on the two sides of S are tangent one another at x0) and the parameter D measures the deviation of the switching manifold from a hyperplane. The proposed result is based on an extension of the classical fold bifurcation theory available for smooth maps. Construction of a suitable smooth map is a crucial step of the proof.
A study of the factors controlling the differentiation of Mauthner's cell in amblystoma

The anatomical relationships of Mauthner 's neuron in Amphibia have been described and figured by previous investigators (Beccari, '07; Herrick, '14, pp. 379-380 and figs. 12 and 53, '30, fig. 17; Detwiler, '27; Coghill, '34). I t is known that the lateral dendrite of Mauthner 's cell is quite large and ramifies throughout the entire territory of the entering VIIth and VIIIth cranial nerve roots as well as both dorsal and ventral lateral-line tracts of the Xth nerve in this vicinity (fig. 1). The medial dendrite, though probably less extensive, makes contact with both ascending and descending tegniental tracts and locally with cells of the nucleus motorius tegmenti. The remarkable constancy with which this single, highly specialized cell appears always at the point of entrance of the VIIth and VIIIth nerve roots in the amphibiain medulla would, on a priori grounds, suggest that there may exist a necessary developmeiital relationship between the two , i.e., Mauthner ' s cell is caused to differentiate as such by virtue of a developmental stimulus imposed upon this particular region by the lateral-line roots and/or vestibular roots. As a matter of fact, however, experimental proof for this thesis is so far lacking. Actually, several investigators, in-
The First Empirical Demonstration of Transference in Psychotherapy

This study investigates the similarity between patients' relationships with their therapists and patients' relationships with others in their life. We examined the in-session narratives about the therapist and compared them with the patient's general relationship pattern as determined by a previously tested method, the Core Conflictual Relationship Theme (CCRT) method. The source for both narratives and CCRT patterns were transcripts of therapy sessions from 35 consenting outpatients in a university clinic. We found significant similarity between the patterns of relationship with the therapist and with others. One aspect of the relationship pattern, the patient's response to the therapist and to others, was consistently similar. We offer objective evidence in support of an age-old and central tenet of psychodynamic therapy, the transference concept.
THE NEUTRALIZATION OF ENCEPHALITIS VIRUS (ST. LOUIS, 1933), BY SERUM.

The virus of St. Louis encephalitis (1, 2, 3) was found to be inactivated by substances present in convalescent serum by Webster and Fite (2). Experiments designed to determine the prevalence of neutralizing antibodies against this virus were undertaken concurrently in three separate laboratories. The observations of Wooley and Armstrong (4) and Webster, Fite and Clow (5) have been reported. The present paper represents a final report from our laboratory on neutralization tests done on sera from persons in the St. Louis area.
[Changes of blood cells in patients with severe acute respiratory syndrome].

OBJECTIVE To investigate the changes of blood corpuscles of patients with severe acute respiratory syndrome (SARS) in Beijing. METHODS Totally 43 patients (21 male and 22 female, 19-74 years old age range) diagnosed as of probable SARS were included in this study. Their corpuscles in the peripheral blood were tested every two days, and the results were analyzed. RESULTS Patients with SARS were more likely to develop leukocytopenia, lymphopenia and thrombocytopenia in the early period of disease than those in control group. The situation, especially lymphopenia and thrombocytopenia, could not be reversed in patients who died. Persistent low counts of lymphocytes and platelets at presentation might be associated with adverse outcomes. CONCLUSION Low counts of leukocytes, lymphocytes and platelets were common among patients in the early stage of SARS. Persistent Lymphopenia and thrombocytopenia may be associated with the prognosis.
Localization of stimulating electrodes in patients with Parkinson disease by using a three-dimensional atlas-magnetic resonance imaging coregistration method.

OBJECT The aim of this study was to correlate the clinical improvement in patients with Parkinson disease (PD) treated using deep brain stimulation (DBS) of the subthalamic nucleus (STN) with the precise anatomical localization of stimulating electrodes. METHODS Localization was determined by superimposing figures from an anatomical atlas with postoperative magnetic resonance (MR) images obtained in each patient. This approach was validated by an analysis of experimental and clinical MR images of the electrode, and the development of a three-dimensional (3D) atlas-MR imaging coregistration method. The PD motor score was assessed through two contacts for each of two electrodes implanted in 10 patients: the "therapeutic contact" and the "distant contact" (that is, the next but one to the therapeutic contact). Seventeen therapeutic contacts were located within or on the border of the STN, most of which were associated with significant improvement of the four PD symptoms tested. Therapeutic contacts located in other structures (zona incerta, lenticular fasciculus, or midbrain reticular formation) were also linked to a significant positive effect. Stimulation applied through distant contacts located in the STN improved symptoms of PD, whereas that delivered through distant contacts in the remaining structures had variable effects ranging from worsening of symptoms to their improvement. CONCLUSIONS The authors have demonstrated that 3D atlas-MR imaging coregistration is a reliable method for the precise localization of DBS electrodes on postoperative MR images. In addition, they have confirmed that although the STN is the main target during DBS treatment for PD, stimulation of surrounding regions, particularly the zona incerta or the lenticular fasciculus, can also improve symptoms of PD.
Visceral fat area is an independent predictive biomarker of outcome after first-line bevacizumab-based treatment in metastatic colorectal cancer

Background Adipose tissue releases angiogenic factors that may promote tumour growth. Objective To determine whether body mass index (BMI), subcutaneous fat area (SFA) and visceral fat area (VFA) are associated with outcomes in patients given first-line bevacizumab-based treatment for metastatic colorectal cancer (MCC). Patients CT was used to measure SFA and VFA in 120 patients with MCC who received bevacizumab-based treatment (bevacizumab group, n=80) or chemotherapy alone (chemotherapy group, n=40) as first-line treatment. Associations linking BMI, SFA and VFA to tumour response, time-to-progression (TTP) and overall survival (OS) were evaluated. Results In the bevacizumab group, median follow-up lasted for 24 months (3–70). BMI, SFA and VFA values above the median (ie, high BMI, high VFA and high SFA) were significantly associated with absence of a response. TTP was shorter in patients with high BMI (9 vs 12 months; p=0.01) or high VFA (9 vs 14 months; p=0.0008). High VFA was associated with shorter OS (p=0.0493). By multivariate analysis, high VFA was independently associated with response, TTP and OS (HR=7.18, p=0.008, HR=5.79, p=0.005 and HR=2.88, p=0.027, respectively). In the chemotherapy group, median follow-up lasted for 30 months (4–84). BMI, SFA and VFA were not associated with response, TTP or OS. In the whole population, interaction between VFA and bevacizumab administration was significant for response (OR=3.31, p=0.005) and TTP (HR=1.64, p=0.022), thereby confirming the results. Conclusion This study provides the first evidence that high VFA independently predicts a poorer outcome in patients given first-line bevacizumab-based treatment for MCC. However, this predictive biomarker needs to be validated in a different dataset.
PENGARUH KINERJA LINGKUNGAN TERHADAP KINERJA FINANSIAL PERUSAHAAN DENGAN CORPORATE SOCIAL RESPONSIBILITY (CSR) DISCLOSURE SEBAGAIVARIABEL INTERVENING

The study had an objective to examine the effects of work environment to the financial performance of a company with corporate social responsibility (CSR) disclosure as the intervening variable. The environment perfomance was measured through the program of the rating of the company perfomance in managing the living environment (PROPER) and it was revealed in its annual report. The CSR was seen from the index of corporate social responsibility (CSRI) and the financial performance would be proved from its return on assets (ROA). The sample used in this study was the mining companies registered in the Indonesian Stock Exchange, which had joined the PROPER program and issued their annual report in 2008-2011. The number of samples was 49 companies. The instruments to analyze were the path analysis and sobel test. The result of analysis indicated that the environment performance had a negative significant on the companies’ financial performance, but it had a positive significant on the corporate social responsibility (CSR) disclosure. The disclosure of corporate social responsibility had no significant effect on the companies’ financial performance. However, the disclosure of CSR was not the variable which mediated the effect of environment performance to the companies’ financial performance.