Miracle-dz/UniFAR-FTUs huggingface dataset:
Essentials of Clinical Endocrinology.

Schneeberg and his contributors (Banghart, Bendersky, Eskin, Paul, Shaw, Smith, and the Steinbergers) have accomplished exactly what they set out to do in superb fashion: prepare a tight, up-to-date synopsis of clinically relevant endocrinological information. The style is simple and straightforward, and it makes an extraordinary density of information quite readable. A very practical clinical orientation is evident throughout: in discussing the treatment of hyperthyrodism, Schneeberg states: Criteria useful in selecting individual treatment are outlined below, but the choice depends to a large extent on the experience of the physician, local surgical skills and isotope facilities, and the convenience, comfort and wishes of the patient. How refreshingly different from the usual dogmatic recommendations! In controversial areas, the author treads a very reasonable middleground; perhaps the necessity for conciseness made it impossible to indicate in greater detail the range of authoritative opinions. However, the reader is given excellent bibliographic referrals, should
Effect of Fruit Anthocyanin Consumption on Cognition, Blood Pressure and Other Health Parameters in Older Adults

ii Acknowledgments . vi Certification . viii Dedication . ix List of Abbreviations . x Publications constituting this thesis . xiii Peer reviewed publications . xiii Conferences abstracts . xiv Prizes and Awards . xv Media coverage of thesis related research . xv List of funding sources supporting this thesis . xvi Table of
Academics in public office as policy entrepreneurs: their important role in Indonesia’s administrative reform

ABSTRACT Indonesia has a tradition in recruiting a particular ‘species’ of policy entrepreneur, mentioned in the present article as Academic Administrative Entrepreneurs (AAEs). AAE is defined as a university professor who is employed into public office due to their expertise in specific policy areas and their access to various forms of knowledge, social, and political capital. AAEs investigated in this study were instrumental in leading and managing national administrative reform policy in post-authoritarian Indonesia (1998-onwards). This article explores how AAEs start and initiate the reform agenda, identifies what resources they invest, challenges and barriers they encountered, and their effectiveness in leading and managing change. Based on a series of interviews with AAEs and their colleagues, it is observed that AAEs are qualified to be identified as a policy entrepreneurs as they meet essential elements required where the balance of knowledge, political and social capital and good timing in relation to the political salience of their expertise enable them influence processes of administrative reform. However, they tended to be more effective on incremental change which contains little political risk where it is noted that the context of transition to democracy works as an important antecedent condition of their effectiveness.
Principles of Food, Beverage, and Labor Cost Controls

Download PDF Ebook and Read OnlinePrinciples Of Food Beverage And Labor Cost Controls%0D. Get Principles Of Food Beverage And Labor Cost Controls%0D Amazon com Principles of Food Beverage and Labor Cost Principles of Food, Beverage, and Labor Cost Controls, Ninth Edition has defined the cost control course for generations of students. This new edition continues the tradition of presenting comprehensive yet concise information on cost control that is updated to reflect today's technology driven environment Key terms, key concepts, review questions, and spreadsheet exercises reinforce and http://home.schoolnutritionandfitness. com/Amazon-com--Principles-of-Food--Beverage--and-Labor-Co st--. pdf Principles of Food Beverage and Labor Cost Controls Principles of Food, Beverage, and Labor Cost Controls, Eighth Edition is the essential text for understanding the ins and outs of controlling food, labor, and beverage costs. It comes accompanied by ProMgmt Student Workbook, which allows students to obtain a certificate from the National Restaurant Association Educational Foundation. http://home.schoolnutritionandfitness. com/Principles-of-Food--Beverage--and-Labor-Cost-Controls--. p df Principles of Food Beverage and Labor Cost Controls For Principles of Food, Beverage, and Labor Cost Controls, Sixth Edition equips culinary and hospitality management students with the knowledge and skills they need to perform one of the most important aspects of their jobs. About the Author. http://home.schoolnutritionandfitness. com/Principles-of-Food--Beverage--and-Labor-Cost-Controls--Fo r--. pdf NINTH EDITION PRINCIPLES OF FOOD BEVERAGE AND LABOR COST costs into consideration. Food, beverage, and labor costs generally represent between 60% and 70% of the toal costs of a restaurant operation. If these costs are not carefully established and monitored, they can gradually increase until profit is eliminated and losses are sustained. http://home.schoolnutritionandfitness. com/NINTH-EDITION-PRINCIPLES-OF-FOOD--BEVERAGE--A ND-LABOR-COST--. pdf PDF Principles of Food Beverage and Labor Cost Control Principles of Food, Beverage, and Labor Cost Controls, Eighth Edition is the essential text for understanding the ins and outs of controlling food, labor, and beverage costs. It comes accompanied by ProMgmt Student Workbook, which allows students to obtain a certificate from the National Restaurant Association Educational Foundation. Includes a diskette which contains Excel spreadsheet http://home.schoolnutritionandfitness. com/-PDF--Principles-of-Food--Beverage-and-Labor-Cost-Contr ol--. pdf Principles of Food Beverage and Labor Cost Controls 9th Principles of Food, Beverage, and Labor Cost Controls, Ninth Edition has defined the cost control course for generations of students. This new edition continues the tradition of presenting comprehensive yet concise information on cost control that is updated to reflect today's technology
Up-regulated long non-coding RNA DUXAP8 promotes cell growth through repressing Krüppel-like factor 2 expression in human hepatocellular carcinoma

Background and aim Long non-coding RNAs (lncRNAs) are implicated as novel factors in tumorigenesis and tumor progression. Although thousands of lncRNAs have been discovered, only a small portion have been functionally determined in hepatocellular carcinoma (HCC). Here, we aimed to comprehensively analyze differentially expressed lncRNAs, evaluate their clinical significance, and explore the functional roles and underlying mechanism in HCC. Methods We identified hundreds of lncRNAs which were dysregulated in HCC tissues through performing integrative analyses using the RNA sequencing data and independent gene microarray data from Gene Expression Omnibus and the Cancer Genome Atlas. Results Dysregulated DUXAP8, LINC01116, LINC01138, and PCAT6 are significantly associated with HCC patients' poor outcomes. Further experimental validation revealed that down-regulation of lncRNA DUXAP8 inhibited HCC cells proliferation and colony formation ability. Mechanistically, DUXAP8 repressed tumor suppressor KLF2 transcription through interacting with histone-lysine N-methyltransferase enzyme enhancer of zeste homolog 2. Conclusion Taken together, our findings can provide a valuable resource of HCC-associated lncRNAs and new insights into the biological functions of lncRNAs in HCC development.
Evaluation of cytological pattern of cervical Papanicolaou smears

Background and Objective: Cervical cancer is one of the most common cancers in India and leading cause of morbidity and mortality. Cervical cancer is preventable, and can be diagnosed at the pre-invasive stage with adequate and repetitive cytological screening with Papanicolaou (Pap) smears. This is a prospective study aimed to evaluate all the cervical smears examined at our institute during one year period. Methods: Detailed clinical data and Pap smear cytology were obtained from August 2013 to July 2014. After doing Pap stain, all cases were reported as per the 2001 Bethesda system. Results: A total of 450 Pap smears were examined. Maximum number of patients was in the age group of fourth decade. There were 40 unsatisfactory or inadequate samples (8.6%). A total of 388 smears were reported as Negative for Intraepithelial Lesion or Malignancy (NILM), of which 80(17.8%) showed normal cytological findings and 308(68.5%) were inflammatory. Out of a total of 330(73.4%) abnormal Pap smears, only 22(4.9%) cases were reported to have epithelial cell abnormality. The 22 abnormal cases comprised of 10 cases with ASC-US, 6 cases of LSIL, 3 cases of HSIL and 3 cases of Invasive Squamous Cell Carcinoma. Conclusion: Pap smear is an easy and economical screening method to detect premalignant and malignant lesions of cervix which help in proper treatment. It also suggests a need for further evaluation and follow-up.
Does Botulinum Toxin A Injections Into The Pelvic Floor Muscles of Women with Chronic Genitopelvic Pain and Vaginal Spasm Improve Pain and Sexual Functioning

OBJECTIVE: The objective of this evidenced based medicine review is to determine whether or not botulinum toxin A injections into the pelvic floor muscles of women with chronic genitopelvic pain and vaginal spasm improve pain and sexual functioning. STUDY DESIGN: Review of two double blind randomized controlled trials and one case series from peer reviewed journals published between 2006-2011. DATA SOURCES: Two randomized controlled trials and one case series were found using PubMed, Google Scholar, and Cochrane Library. OUTCOMES MEASURED: All three studies measured pain and sexual functioning using selfreported surveys including the visual analog scale for pain, Female Sexual Functioning Index, and Sexual Activity Questionnaire. RESULTS: Petersen et al. determined that botulinum toxin injections into the vulva did not improve pain or sexual functioning in vestibulodynia patients when compared to the control group. Similarly, Abbott et al. found that botulinum toxin injections into the pelvic muscles for chronic pelvic pain did not improve pain or sexual functioning when compared to the control group. In the case series conducted by Pelletier et al., botulinum toxin injections into the vulva reduced pain and improved sexual functioning for vestibulodynia patients. CONCLUSION: Botulinum toxin type A injections into the pelvic floor muscles are not an effective form of treatment for chronic pelvic pain or vestibulodynia. Both randomized controlled trials contributed the improvement in the control group to the placebo effect, among other theories. In the future, randomized controlled trials should use a larger sample size and include a nocebo group to further elaborate on the above results.
Esmolol Infusion Reduces Blood Loss and Opiate Consumption during Fertility Preserving Myomectomy

Objectives: The objective of this study is to evaluate the effect of esmolol-induced hypotensive anesthesia (EIHA) on intra-operative (IO) bleeding during open myomectomy. Patients and Methods: Eighty-eight women were randomly divided into the study group received EIHA without uterine tourniquet and control group who received normotensive anesthesia with uterine tourniquet. EIHA was provided as priming dose of esmolol (0.5 mg.kg-1) before the induction of anesthesia and esmolol infusion (0.05-0.3 mg.kg-1.min-1) to maintain mean arterial pressure at 60–70 mmHg that was stopped on completion of myomectomy. Fentanyl was used as IO analgesia (loading dose: 1.0 μg.kg-1 then infusion of 0.2-0.4 μg.kg-1.h-1). All patients received 6% hydroxyethyl starch (HES; initially, 3 mL.kg-1 over 5-10 minutes and supplemental doses according to requirements) and Lactated Ringer's solution (LR; 5 mL.kg-1.h-1). Trigger for blood transfusion was hemoglobin concentration (HBC) <7 g.dL-1. Study outcomes included the extent of postoperative (PO) HBC deficit in relation to preoperative HBC, frequency of tourniquet application for the study patients, and total fentanyl consumption. Results: EIHA significantly reduced blood pressure measures since laryngoscopy and tracheal intubation till the end of surgery in the study group compared to control group. Eight study patients (18.9%) required tourniquet application for control of bleeding; however, amount of IO blood loss; total field visibility score and PO HBC deficit were non significantly lower in the study group. EIHA allowed significant reduction of the IO amount of LR and additional amounts of HES infusions. Study patients group consumed significantly lower IO fentanyl doses with significantly longer duration till the 1st PO request and the number of additional fentanyl, and lower numeric rating scale scores in study group compared to controls. Conclusion: Open myomectomy under EIHA is feasible and safe and allows fertility-sparing with minimal risk of blood transfusion. The applied procedure of EIHA allowed blunting of pressor reflexes secondary to LIT, surgical stresses and extubation, and allowed reduction of IO and PO opioid doses.
Group Therapy For Cancer Patients: A Research-based Handbook Of Psychosocial Care

This extraordinary resource celebrates and expands on Dr. David Spiegel's discovery that a shared intimacy with mortality creates very different concerns in the patient from those that apply in conventional settings. Spiegel and Classen introduce mental health professionals to the awareness as well as the tools they will need to facilitate groups coping with existential crises. The result is a model for helping that actually helps.
Fundamental Toxicological Sciences

Rare sugar D-allulose prevents obesity; however, an excessive and continuous intake of D-allulose may induce weight increases in the liver and kidney without apparent pathological and functional abnormalities. Conversely, there has not been reported about how these parameters will change after cessation of D-allulose intake. In this study, effects of a 10-week D-allulose cessation on liver and kidneys weights and biomarkers were investigated in rats previously fed a D-allulose containing diet for 4 weeks. Wistar rats were fed a control diet (C, n=16) or a 3% D-allulose diet (DA, n=16) for 4 weeks, and then the half of rats in the C and DA subgroups were dissected, while the other half of rats were fed the control diet for 10 weeks (C-C and DA-C, n=8, respectively). At the end of the first 4 weeks period, halves of rats in each diet group were euthanized, and the serum, urine, liver, and kidneys were used for pathological and biochemical analyses. The remaining rats were also similarly treated at the end of latter 10 weeks treatment. At week 4, the relative weights of the liver and kidneys were higher in the DA group than in the C group, but these differences were disappeared by cessation of D-allulose. No abnormal parameters related to liver and kidneys functions were observed in the serum and urine. These findings suggested that D-allulose-induced increases in the liver and kidneys weights could be recovered to the normal levels by D-allulose cessation without accompanying functional and pathological abnormalities.
Exploring the Role of the Parish Nurse In Providing Diabetes Education and Preconception Counseling to African American Women Using a Community-Engaged Mixed-Methods Approach

Purpose: The purpose of this study is to explore the experiences of parish nurses (PNs) in providing diabetes education and preconception counseling (PC) to women (especially African American [AA] women) with type 1 diabetes (T1D) and type 2 diabetes (T2D) and their understanding of diabetes as it relates to pregnancy and pregnancy outcomes; and to describe the parish nurses’ knowledge and teaching self-efficacy regarding diabetes, pregnancy and PC. Methods: A mixed-method concurrent embedded design using focus group methodology as the primary method and a quantitative descriptive design with three self-report measures (demographic, PC self-efficacy, and PC knowledge) as the secondary method was utilized. Forty-eight parish nurses participated in one of eleven focus groups. Qualitative content analysis was conducted and combined with descriptive measure analysis. Results: Seventeen qualitative themes emerged from the discussions with the PNs: 1) role, 2) approach, 3) challenges, 4) support network 5) practice and programs, 6) diabetes practice and programming, 7) diabetes and pregnancy and PC practice and programs, 8) awareness, 9) experience, 10) formal training, 11) importance and usefulness, 12) willingness, 13) forming a social network of wise women, 14) confidence, 15) need for training, 16) recommendations for PC training for PNs, and 17) recommendations for PC tool for patients. PNs’ knowledge scores were low (mean= 65%, range= 40-100%) with only moderate levels of self-efficacy (mean= 99, range = 27-164). Self-efficacy had a significantly positive association with knowledge, as knowledge increased self-efficacy increased (Pearson r = .292, p =. 05). Conclusions: Quantitative results confirmed PNs’ qualitative statements. PNs were unaware of PC and lacked both knowledge and teaching self-efficacy as it related to PC/diabetes education. Understanding PNs’ experiences with women with diabetes and identifying their needs to provide education and PC will help tailor training interventions that could impact maternal and fetal outcomes.
Complete Response after Long-Term 2nd Line Treatment with Trabectedin in a Hemodialyzed Patient with Metastatic High-Grade Ovarian Sarcoma, Case Report and Short Review

Primary ovarian sarcomas are very rare tumours and are characterized by poor prognosis. Surgical treatment is mainly based on epithelial ovarian cancer debulking approaches, while chemotherapy is based on data extrapolation from studies in sarcomas of other primary sites. Trabectedin has been established as a standard of care for the treatment of soft-tissue sarcomas in the 2nd line setting. So far, no data from randomized clinical trials support specific maximum number of cycles of trabectedin for any gynaecological sarcoma. Moreover, limited evidence in the literature supports the feasibility and safety of trabectedin administration in haemodialyzed patients. This report presents the case of a 48-year old female diagnosed with metastatic high-grade undifferentiated sarcoma of the right ovary. She underwent primary surgery followed by 1st line chemotherapy with doxorubicin plus ifosfamide, and had a partial response after cycle 3. However, treatment tolerance was very poor with grade 3 and 4 hematologic and non-hematologic toxicities, including the development of chronic kidney failure that required permanent haemodialysis. Treatment was changed to trabectedin, leading to a complete response that is ongoing and lasts for over 2 years. Our case supports safety of long-term trabectedin administration in a hemodialyzed patient with the achievement of durable complete disease response on the metastatic setting.
The Development of the Microteaching Movement in Europe.

This paper describes the development and dissemination of microteaching methods in Europe and some African countries, with emphasis on the United Kingdom and Germany. A tool for teacher preparation, microteaching trains teaching behaviors and skills in small group settings aided by video-recordings. Consistent with education reform efforts, the European microteaching movement grew out of a dissatisfaction with three features of the prevailing model of traditional teacher education programs: (1) that student teachers could become reflective and skilled practitioners by separating academic studies from practical experience; (2) professional education courses' and (3) inadequate and unsystemmatic field observations and experiences. Attempts to reform and democratize universities and colleges, development of other laboratory-based teacher training methods, the revival of empirical analytical research, and introduction of video into educational settings are presented. Also presented are: adaptations, developments, and uses of microteaching in Europe; a comparison of the United States and European approaches; and a discussion of research on microteaching in Europe. An extensive list of 174 references is included. (LL) *********************************************************************** Reproductions supplied by EDRS are the best that can be made from the original document. ***********************************************************************
Audit Committee Oversight and Financial Reporting Reliability: Are Audit Committees Overloaded?

We examine the relation between audit committee (AC) responsibilities and financial reporting reliability. AC responsibilities have increased over time, prompting concerns that overloading ACs with duties unrelated to core financial reporting oversight may impair financial reporting. Using new AC charter-based proxies to measure AC responsibilities, we find that allocating non-core responsibilities to the AC is associated with reduced financial reporting reliability. This association is exacerbated when AC members are busy with multiple board appointments and ameliorated when ACs have more members to execute duties. In contrast, we find that having more core financial reporting-related AC responsibilities is associated with improved financial statement reliability; this association persists even when ACs have very high levels of reporting-related responsibilities. Collectively, our evidence suggests that non-core duties overload ACs and harm reporting reliability but increasing AC duties related to financial reporting does not appear to overload ACs nor detract from financial reporting reliability.
Attention Allocation and Return Co-Movement: Evidence from Repeated Natural Experiments

Abstract We hypothesize that when investors pay less attention to financial markets, they rationally allocate relatively more attention to market-level information than to firm-specific information, leading to increases in stock return co-movements. Using large jackpot lotteries as exogenous shocks that attract investors’ attention away from the stock market, we find supportive evidence that stock returns co-move more with the market on large jackpot days. This effect is stronger for stocks preferred by retail investors and is not driven by gambling sentiment. We also find that stock returns are less sensitive to earnings surprises and co-move more with industries on large jackpot days.
R&D Investment and Distress Risk

This paper proposes that besides volatility, R&D can increase firms' distress risk through another channel. Unlike capital investment, R&D is more inflexible and subject to high adjustment costs. Moreover, R&D intensive firms face severe financial constraints and are more likely to suspend/discontinue R&D projects. Therefore, firms' distress risk increases with their R&D intensity. Using a large panel of US companies over the 1980 to 2011 period, I find a robust empirical relation between R&D and distress risk, primarily among financially constrained firms. Moreover, the effect of R&D on distress risk is magnified during economic downturns. I also find that firms that have been previously successful in R&D or firms with high analyst coverage can mitigate the relationship between R&D and distress risk.
Interlinkages and the Effectiveness of Multilateral Environmental Agreements

In recent years there has been growing awareness that a major reason for the worsening global environment is the failure to create adequate institutional responses to fully address the scope, magnitude and complexity of environmental problems. Much of the criticism directed at the global institutions has focused on the necessity for greater coordination and synergism among environmental institutions, policies and legal instruments, and the need for approaches that take better account of the inter to relationships between ecological and societal systems. This book seeks to fill the gap in Knowledge and policy to making that exists, particularly in international law.