Miracle-dz/UniFAR-FTUs huggingface dataset:
A directed search for quantitative trait loci on chromosomes 4 and 7 in pigs.

Improvements in the porcine genetic map and availability of resource families to study performance traits in pigs have made it possible to re-examine previous findings that linked certain traits to genes or chromosomal regions. Previous studies suggested that chromosomes 4 and 7 may be associated with growth and performance traits. To confirm these previous results, an interval mapping-regression approach was used to determine whether quantitative trait loci (QTL) exist in the Iowa State University reference/resource families. Traits measured were birth weight; body weight at 21 d; weaning weight (weight at 42 d); average daily gain; backfat at the first, 10th, lumbar, and last ribs and average backfat thickness; loin eye area; meat color; marbling; and firmness. The total number of F2 pigs used ranged from 241 to 330 and came from five Chinese x American resource families. Five markers (S0001, SW871, S0175, S0214, and SW445) were genotyped and mapped on chromosome 4, and so were 10 markers (S0064, tumor necrosis factor alpha [TNFalpha], S0102, S0078, S0158, S0066, SW304, SW1083, S0101, and S0212) on chromosome 7. Data were analyzed for each family (breed cross) separately and were also pooled. Experiment-wise thresholds were used to determine significance. Suggestive evidence of QTL on chromosomes 4 and 7 was observed for several traits in pooled and individual family analyses. Suggestive evidence of a QTL with a relatively large effect for average daily gain was detected on chromosome 4 in the pooled analysis. Significant (P < .05) evidence for QTL was seen on chromosome 7 for 10th-rib, last-rib, and average backfat thickness in the pooled data set in a region of the chromosome that was near TNFalpha. These results verify in part that chromosomes 4 and 7 contain QTL for growth and carcass traits.
Foreign Direct Investment and Labor Quality in Developing Countries

The quality of local labor is an important factor in a multinational corporation's (MNC) decision to set up production operations in a developing country. It is often observed that developing country governments attempt to attract MNCs by enhancing labor quality. This paper studies the interaction between an MNC and a local government which has superior information on local labor quality. The local government has an incentive to enhance the labor quality and share that information with the MNC because it increases both its net tax revenue and profit of the MNC. The paper provides an explanation for recent findings of FDI in developing countries: the bulk of FDI has been directed toward a limited number of countries and human capital plays an increasingly important role in attracting FDI.
Contributions of Intracellular Compartments to Calcium Dynamics: Implicating an Acidic Store

Many cells show a plateau of elevated cytosolic Ca2+ after a long depolarization, suggesting delayed Ca2+ release from intracellular compartments such as mitochondria and endoplasmic reticulum (ER). Mouse pancreatic β‐cells show a thapsigargin‐sensitive plateau (‘hump’) of Ca2+ after a 30 s depolarization but not after a 10 s depolarization. Surprisingly, this hump depends primarily on compartments other than the mitochondria or ER. It is reduced by only 22% upon blocking mitochondrial Na+–Ca2+ exchange and by only 18% upon blocking ryanodine or IP3 receptors together. Further, the time course of ER Ca2+ measured by a targeted cameleon does not depend on the duration of depolarizations. Instead, the hump is reduced 35% by treatments with the dipeptide glycylphenylalanine β‐napthylamide, a tool often used to lyse lysosomes. We show that this dipeptide does not disturb ER functions, but it lyses acidic compartments and releases Ca2+ into the cytosol. Moreover, it induces leaks in and possibly lyses insulin granules and stops mobilization of secretory granules to the readily releasable pool in β‐cells. We conclude that the dipeptide compromises dense‐core secretory granules and that these granules comprise an acidic calcium store in β‐cells whose loading and/or release is sensitive to thapsigargin and which releases Ca2+ after cytosolic Ca2+ elevation.
Managing critical drivers for building information modelling implementation in the Singapore construction industry: an organizational change perspective

ABSTRACT Building information modelling (BIM) implementation has been mandated in the Singapore construction industry, but it is still plagued with challenges such as lack of contractor input in design models. Thus, the industry still needs changes in the BIM implementation. This study aims to identify critical drivers for change (CDCs) towards full BIM implementation, demonstrate the theoretical rational behind the CDCs, and formulate strategies to strengthen the CDCs. Conducting a questionnaire survey with 86 professionals, this study identified 31 CDCs, among which ‘BIM vision and leadership from the management’ was ranked top. The results indicated that these CDCs could be interpreted with an adapted organizational change framework in which process-related attributes were key to changing towards full BIM implementation. The identification of the CDCs and the strategies enables the project management team to obtain sufficient support for strengthening the positive influence from the CDCs and enhancing BIM implementation. Additionally, overseas construction practitioners can use the drivers and strategies identified in this study to prepare their customized lists of drivers and strategies.
Influence of Corporate Control and Ownership Structure on the Value of Firms Listed at the Nairobi Securities Exchange

This study aimed at establishing the influence of corporate control and ownership structure on corporate values of companies listed at the Nairobi Securities Exchange. The paper tested the hypothesis that there is no significant moderating impact of ownership structure on the relationship between corporate control and corporate value growth based on Tobin Q and ROA measurements. The theory applied were agency theory, stewardship theory and stakeholder theory with the main anchoring theory being the agency theory. The study applied census survey for sixty four firms listed at the NSE. The time frame of analysis is five years between 2013 and 2017. Out of the 64 listed companies targeted, 58 were analyzed forming 90% of the population. The study applied census survey given that the population of the listed companies at the NSE were not many. Out of the 64 listed companies targeted, 59 were analyzed forming 92% of the population. Corporate control index was developed as a proxy for corporate control and ownership structure index was developed as a proxy for ownership structure. While ROA and Tobin Q were used to measure corporate value. The hypotheses were tested using both correlation and regression analysis. The key study variables of the listed companies were subjected to descriptive statistics and the results revealed a significant positive relationship between the variables. The study findings revealed significant moderating effect on the relationship between the value of the firm and its ownership structure.
Pathways of purine metabolism: effects of exercise and training in competitive athletes

Introduction. The main part of skeletal muscle adenosine5'-triphosphate (ATP) is restored by inosine monophosphate (IMP) reamination in the purine nucleotide cycle. The intramuscular resources of IMP may be resynthesized via the quick and economical salvage pathway, in which muscle hypoxanthine (Hx) is reconverted to IMP by hypoxanthineguanine phosphoribosyl transferase (HGPRT). IMP is subsequently reutilized in the adenine nucleotide (AdN) pool. Inosine and Hx, which flow out of the skeletal muscle, represent the loss of AdN precursors. In the latter case, full restoration of resting ATP levels depends on a slow and energy-consuming de novo pathway. Plasma Hx and erythrocyte HGPRT are indirect indicators of muscle metabolism, particularly of AdN degradation, that reflect exerciseand training-induced muscle energy status. Results. Our analyses of long-term training cycles in different sports show that plasma Hx concentration and erythrocyte HGPRT activity significantly change in consecutive training phases. Both high-intensity sprint training and endurance training incorporating high-intensity exercise lead to a decrease in plasma Hx levels and an increase in erythrocyte HGPRT activity. The lowest Hx concentration and the highest HGPRT activity are observed in the competition phase characterised by low-volume and high-intensity training loads. Training cessation in the transition phase brings about a reverse phenomenon: an increase in Hx levels and a decrease in HGPRT activity. Conclusions. Low plasma purine levels indicate that the administered training adapts the athletes to high-intensity exercise (more economical AdN use, limited purine efflux from muscle into the blood). Such an adaptation is of great importance for contemporary elite athletes. Purine metabolites are more sensitive markers of training status and better performance predictors than typical biochemical and physiological indicators (e.g. blood lactate and oxygen uptake) in highly-trained athletes of different specializations and ages. The use of Hx and HGPRT for monitoring and control of the training process is worthy of consideration.
Inflammatory pseudotumors of lymph node origin show macrophage- derived spindle cells and lymphocyte-derived cytokine transcripts without evidence of T-cell receptor gene rearrangements. Implications for pathogenesis and classification as an idiopathic retroperitoneal fibrosis-like sclerosing immune

Sclerosing pseudotumorous immune reactions of the retroperitoneum have been shown to consist of HLA-DR-positive spindle-shaped fibroblasts and macrophages that resemble fibroblasts, and in some instances they contain clonal populations of T lymphocytes not found in granulation tissue, keloids, nodular fasciitis, or fibromatoses. In patients who are iatrogenically immunosuppressed, circulating monocytes may be induced in vitro to transform into spindle-shaped macrophages, and secrete collagen after stimulation by conditioning medium from activated T lymphocytes. The authors investigated a series of five inflammatory pseudotumors (IPT) of lymph node origin for identification of spindle-shaped macrophages, T-cell receptor gene rearrangements, and lymphocyte-derived cytokine mRNA production. All cases of IPT demonstrated spindle-shaped macrophages resembling fibroblasts or myofibroblasts characterized by vimentin, CD45 (LCA), CD68 (KP1) or HAM-56, and HLA-DR(LN3) immunoreactivity and demonstrated production of procollagen-alpha1 (I) mRNA by in situ hybridization. Clonal T-cell receptor chain gene rearrangements were undetectable by polymerase chain reaction. Strong specific lymphocyte-derived interleukin-1beta and interleukin-6 mRNA cytokine transcripts were identified. Although all patients with IPT were managed with steroids and nonsteroidal anti-inflammatory medication, some had treatment-refractory disease. Because all-trans retinoic acid has been demonstrated to inhibit the in vitro transformation of monocytes into collagen-producing spindle-shaped macrophages ("neofibroblasts"), it may be of benefit for patients with IPT.
Pengaruh Rasio Likuiditas, Leverage, Profitabilitas, Dan Pertumbuhan Perusahaan Terhadap Penerimaan Opini Audit Modifikasi Going Concern (studi Pada Perusahaan Manufaktur Yang Terdaftar Pada Bursa Efek Indonesia Selama Periode Tahun 2012-2014)

Opini audit modifikasi going concern adalah opini audit yang dikeluarkan oleh auditor untuk mengevaluasi apakah ada kesangsian tentang kemampuan entitas untuk mempertahankan kelangsungan hidupnya. Auditor menetapkan penerimaan opini audit modifikasi going concern apabila dalam proses audit ditemukan kondisi dan peristiwa yang mengarah pada kesangsian terhadap kelangsungan hidup perusahaan. Penelitian ini bertujuan untuk menganalisis penerimaan opini audit modifikasi going concern melalui beberapa faktor yaitu likuiditas, leverage, profitabilitas dan pertumbuhan perusahaan. Penelitian ini menggunakan perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia tahun 2012 – 2014 sebagau sampel. Populasi penelitian ini sebanyak 47 perusahaan. Sampel penelitian berjumlah 19 perusahaan yang dipilih dengan metode purposive sampling, dengan pengamatan 3 tahun. Metode yang digunakan untuk menganalisis hubungan antar variabel adalah metode regresi logistik. Hasil penelitian menunjukan bahwa secara simultan terdapat pengaruh yang signifikan antara likuiditas, leverage, profitabilitas dan pertumbuhan perusahaan terhadap penerimaan opini audit modifikasi going concern. Secara parsial likuiditas berpengaruh negatif signifikan terhadap penerimaan opini audit modifikasi going concern. Sedangkan leverage, profitabilitas dan pertumbuhan perusahaan tidak berpengaruh signifikan terhadap penerimaan opini audit modifikasi going concern. Kata Kunci: Likuiditas, Leverage, Profitabilitas, Pertumbuhan Perusahaan, dan Opini Audit Modifikasi Going Concern
Tackling teenage turmoil: primary care recognition and management of mental ill health during adolescence.

This paper examines how primary care can improve for teenagers who are experiencing mental or emotional turmoil. This is an important health issue because at least 15% of teenagers experience mental health problems at any one time, there are indications that this proportion is rising, and there is evidence that suicide rates are rising in young people. The paper discusses how troubled teenagers can be identified, cared for and managed by primary care providers within the UK, although some of the information presented is from other countries. It identifies inter-relationships with other health behaviours and risk factors. The GP's role in assessing a troubled teenager is discussed, as well as a consideration of individual and contextual issues to frame a "triple" diagnosis, i.e. a diagnosis simultaneously in biomedical, individual and contextual terms. A review of present knowledge of management is presented. The paper concludes that there are several deficiencies at present, namely a lack of identification of teenage distress, a lack of training for GPs in teenage health, a lack of a research base, a lack of resources and finally a lack of information provided by any teenagers who have experienced turmoil and could give useful insights into their experience.
Bovine herpesvirus 1 UL49.5 homolog gene encodes a novel viral envelope protein that forms a disulfide-linked complex with a second virion structural protein

We previously reported that the genome of bovine herpesvirus 1 (BHV-1) contains an open reading frame (ORF) homologous to the herpes simplex virus UL49.5 ORF, and as with the herpes simplex virus UL49.5 ORF, the deduced amino acid sequence of the BHV-1 UL49.5 homolog (UL49.5h) contains features characteristic of an integral membrane protein, implying that it may constitute a functional gene encoding a novel viral envelope protein. This communication reports on the identification of the BHV-1 UL49.5h gene product. By employing an antibody against a synthetic BHV-1 UL49.5h peptide and an UL49.5h gene deletion mutant, the primary product of BHV-UL49.5h gene was identified as a polypeptide with a size of approximately 9 kDa; in both infected cells and isolated virions, the UL49.5h products were found to exist in three forms; monomer, disulfide-linked homodimer, and disulfide-linked heterodimer containing a second viral protein with a size of about 39 kDa. O-Glycosidase digestion and [3H]glucosamine labelling experiments showed that the UL49.5h protein is not glycosylated. Although the deduced amino acid sequence contains putative sites for myristylation and phosphorylation, we were unable to detect either modification. Surface labelling and trypsin digestion protection experiments showed that the BHV-1 UL49.5h protein was present on the surface of infected cells and on the surface of mature virions. Nonionic detergent partition of isolated virions revealed that the UL49.5h protein is more tightly associated with the virion tegument-nucleocapsid structure than envelope protein gD. The results from this study demonstrate that the BHV-1 UL49.5h gene encodes a nonglycosylated virion envelope protein which may associate with virion internal structures by forming a complex with the 39-kDa virion structural protein.
Can a Tiger Change its Stripes? Reform of Chinese State-Owned Enterprises in the Penumbra of the State

The majority of state-owned enterprises (SOEs) in China were privatized through ownership reforms over the last two decades. Using a comprehensive dataset of all medium and large enterprises in China between 1998 and 2013, we show that privatized SOEs continue to benefit from government support relative to private enterprises. Compared to private firms that were never state-owned, privatized SOEs are favored by low interest loans and government subsidies. These differences are more salient with the Chinese government’s trillion-dollar stimulus package introduced after the 2008 global financial crisis. Moreover, both SOEs and privatized SOEs significantly under-perform in profitability compared to private firms. Nevertheless there are clear improvements in performance post-privatization. The tiger can change its stripes; however, the government’s behavior seems to be sticky.
Monocyte adhesion to mesangial matrix modulates cytokine and metalloproteinase production.

BACKGROUND Monocytes migrate into the glomerular mesangium during acute inflammatory renal disease, differentiate into macrophages, and may play a key role in the development and progression of glomerular scarring. Treatment strategies that inhibit monocyte infiltration ameliorate glomerular injury in animal models. Mesangial matrix contains several potential monocyte-binding domains that may contribute to monocyte entrapment and modulate cell activation. METHODS Adhesion of peripheral blood-derived monocytes to matrix synthesized by human mesangial cells and to individual matrix proteins was assessed by colorimetry of nuclear staining with crystal violet. Monoclonal antibodies were used to identify the cell-surface integrins and matrix ligands involved. Monocyte proliferation was assessed by 3H-thymidine incorporation and cytokine production using enzyme-linked immunosorbent assay (ELISA). Secretion of metalloproteinases and their inhibitors was determined by zymography and ELISA, respectively. RESULTS Monocytes bound to matrix synthesized by mesangial cells. Prestimulation of mesangial cells with tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta (TGF-beta) enhanced matrix fibronectin content (P < 0.001) and monocyte binding (P < 0.001). Blocking antibodies to fibronectin, as well as to the integrins very late antigen-4 (VLA-4) and VLA-5, reduced monocyte adhesion to mesangial matrix by approximately 50%. Incubation of monocytes with matrix, fibronectin, laminin and collagen IV enhanced production of interleukin-1beta (IL-1beta), interleukin-6 (IL-6), TNF-alpha and metalloproteinase-9 (MMP-9) when compared to cells incubated in plastic wells. However, there was no apparent difference in proliferation rate and no change in production of metalloproteinase inhibitors. CONCLUSION Monocyte activation within the glomerulus may be mediated by binding to mesangial matrix components, particularly fibronectin. Matrix-mediated activation enhances production of inflammatory cytokines and matrix-degrading enzymes.
Preference after training with differential changeover delays.

Pigeons were trained on a multiple schedule in which each component consisted of concurrent variable-interval (VI) 30-s VI 60-s schedules. The two components of the multiple schedule differed only in terms of the changeover delays (COD): For one component short CODs were employed, and in the second component long CODs were used. After approximate matching was obtained in each component, probe tests involving new combinations of stimuli were presented (e.g., the VI 30-s schedule from each component) to determine how the different CODs affected preference. Despite shorter CODs producing higher changeover rates, the COD value had no systematic effect on preference on the probe trials. However, differences in reinforcement rate always produced preference for the schedule with the higher reinforcement rate. The results thus show that the the pattern of changeover behavior per se is not a critical determinant of choice in the probe-trial procedure.
The nature of the superior sinus venosus defect

The location, and morphology, of the superior sinus venosus interatrial communication remains contentious. As part of a clinical study, we examined anatomic specimens and echocardiograms so as to clarify the arrangement of the normal atrial septal structures, and compared them with the arrangement found in the superior sinus venosus defect. The pathognomonic diagnostic criterion in the abnormal hearts was overriding of the intact muscular rim of the oval fossa by the mouth of the superior caval vein. This muscular rim is, in reality, a tube of myocardium which encloses a core of extracardiac adipose tissue. Understanding of this anatomic conundrum clarifies the understanding of the structures of both the normal atrial septum and sinus venosus defects. Clin. Anat. 11:349–352, 1998. © 1998 Wiley‐Liss, Inc.
Voluntary activation during knee extensions in severely deconditioned patients with chronic obstructive pulmonary disease: Benefit of endurance training

As a consequence of hypoxemia or detraining, a deficit in voluntary activation may contribute to the reduction of strength in chronic obstructive pulmonary disease (COPD). This was studied in 13 severely deconditioned COPD patients and eight healthy subjects. Exercise tolerance, fat‐free mass, and quadriceps maximal voluntary contractions (MVC) were evaluated. Magnetic stimulation was used to measure maximal quadriceps twitch tension (TwQp) at rest and during a voluntary contraction (superimposed twitch: TwQs). A maximal recruitment fraction (MRF) was assessed by the ratio of the true MVC to the maximal achievable strength (using regression of TwQs vs. volitional strength at four submaximal intensities). MRF was significantly lower in COPD than in controls (89 ± 20 vs. 109 ± 6%, P < 0.01). Seven COPD patients completed 3‐month endurance training. After rehabilitation, patients had greater MVC (+24 ± 26 N), associated with a slightly greater MRF (+10 ± 11%). Changes in MRF were independently associated with changes in MVC (r = 0.85, P = 0.03). Deficit in voluntary activation of quadriceps muscle may therefore contribute to muscle weakness in severe COPD patients and is reversed by training. Muscle Nerve, 2007
Complete Genome Sequence of Klebsiella pneumoniae YH43

ABSTRACT We report here the complete genome sequence of Klebsiella pneumoniae strain YH43, isolated from sweet potato. The genome consists of a single circular chromosome of 5,520,319 bp in length. It carries 8 copies of rRNA operons, 86 tRNA genes, 5,154 protein-coding genes, and the nif gene cluster for nitrogen fixation.