Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinical outcomes of a cohort of migrants and citizens living with human immunodeficiency virus in Botswana: implications for Joint United Nation Program on HIV and AIDS 90-90-90 targets

Abstract The aim of the study was to evaluate the human immunodeficiency virus (HIV) treatment cascade and mortality in migrants and citizens living with HIV in Botswana. Retrospective 2002 to 2016 cohort study using electronic medical records from a single center managing a high migrant case load. Records for 768 migrants and 3274 citizens living with HIV were included. Maipelo Trust, a nongovernmental organization, funded care for most migrants (70%); most citizens (85%) had personal health insurance. Seventy percent of migrants and 93% of citizens had received antiretroviral therapy (ART). At study end, 44% and 27% of migrants and citizens, respectively were retained in care at the clinic (P < .001). Among the 35% and 60% of migrants and citizens on ART respectively with viral load (VL) results in 2016, viral suppression was lower among migrants (82%) than citizens (95%) (P < .001). Citizens on ART had a median 157-unit [95% confidence interval (CI) 122–192] greater increase in CD4+ T-cell count (last minus first recorded count) than migrants after adjusting for baseline count (P < .001). Five-year survival was 92% (95% CI = 87.6–94.8) for migrants and 96% (95% CI = 95.4–97.2) for citizens. Migrants had higher mortality than citizens after entry into care (hazard ratio = 2.3, 95% CI = 1.34–3.89, P = .002) and ART initiation (hazard ratio = 2.2, 95% CI = 1.24–3.78, P = .01). Fewer migrants than citizens living with HIV in Botswana were on ART, accessed VL monitoring, achieved viral suppression, and survived. The HIV treatment cascade appears suboptimal for migrants, undermining local 90-90-90 targets. These results highlight the need to include migrants in mainstream-funded HIV treatment programs, as microepidemics can slow HIV epidemic control.
Systematic uncertainties in the determination of the local dark matter density

A precise determination of the local dark matter density and an accurate control over the corresponding uncertainties are of paramount importance for dark matter (DM) searches. Using very recent high-resolution numerical simulations of a Milky Way like object, we study the systematic uncertainties that affect the determination of the local dark matter density based on dynamical measurements in the Galaxy. In particular, extracting from the simulation with baryons the orientation of the Galactic stellar disk with respect to the DM distribution, we study the DM density for an observer located at {approx}8 kpc from the Galactic center on the stellar disk, {rho}{sub 0}. This quantity is found to be always larger than the average density in a spherical shell of the same radius {rho}{sub 0}, which is the quantity inferred from dynamical measurements in the Galaxy, and to vary in the range {rho}{sub 0}/{rho}{sub 0}=1.01-1.41. This suggests that the actual dark matter density in the solar neighborhood is on average 21% larger than the value inferred from most dynamical measurements, and that the associated systematic errors are larger than the statistical errors recently discussed in the literature.
Explaining disparities in oncology health systems delays and stage at diagnosis between men and women in Botswana: A cohort study

Purpose Men in Botswana present with more advanced cancer than women, leading to poorer outcomes. We sought to explain sex-specific differences in time to and stage at treatment initiation. Methods Cancer patients who initiated oncology treatment between October 2010 and June 2017 were recruited at four oncology centers in Botswana. Primary outcomes were time from first visit with cancer symptom to treatment initiation, and advanced cancer (stage III/IV). Sociodemographic and clinical covariates were obtained retrospectively through interviews and medical record review. We used accelerated failure time and logistic models to estimate standardized sex differences in treatment initiation time and risk differences for presentation with advanced stage. Results were stratified by cancer type (breast, cervix, non-Hodgkin’s lymphoma, anogenital, head and neck, esophageal, other). Results 1886 participants (70% female) were included. After covariate adjustment, men experienced longer excess time from first presentation to treatment initiation (8.4 months) than women (7.0 months) for all cancers combined (1.4 months, 95% CI: 0.30, 2.5). In analysis stratified by cancer type, we only found evidence of a sex disparity (Men: 8.2; Women: 6.8 months) among patients with other, non-common cancers (1.4 months, 95% CI: 0.01, 2.8). Men experienced an increased risk of advanced stage (Men: 67%; Women: 60%; aRD: 6.7%, 95% CI: -1.7%, 15.1%) for all cancers combined, but this disparity was only statistically significant among patients with anogenital cancers (Men: 72%; Women: 50%; aRD: 22.0%, 95% CI: 0.5%, 43.5%). Conclusions Accounting for the types of cancers experienced by men and women strongly attenuated disparities in time to treatment initiation and stage. Higher incidence of rarer cancers among men could explain these disparities.
Metalloproteinases and their roles in human cancer

It is now widely appreciated that members of the matrix metalloproteinase (MMP) family of enzymes play a key role in cancer development and progression along with many of the hallmarks associated with them. The activity of these enzymes has been directly implicated in extracellular matrix remodeling, the processing of growth factors and receptors, the modulation of cell migration, proliferation, and invasion, the epithelial to mesenchymal transition, the regulation of immune responses, and the control of angiogenesis. Certain MMP family members have been validated as biomarkers of a variety of human cancers including those of the breast, brain, pancreas, prostate, ovary, and others. The related metalloproteinases, the A disintegrin and metalloproteinases (ADAMs), share a number of these functions as well. Here, we explore these essential metalloproteinases and some of their disease‐associated activities in detail as well as some of their complementary translational potential. Anat Rec, 2019. © 2019 Wiley Periodicals, Inc.
High Thermoregulatory Strain During Competitive Paratriathlon Racing in the Heat.

PURPOSE Paratriathletes may display impairments in autonomic (sudomotor and/or vasomotor function) or behavioural (drinking and/or pacing of effort) thermoregulation. As such, this study aimed to describe the thermoregulatory profile of athletes competing in the heat. METHODS Core temperature (Tc) was recorded at 30 s intervals in 28 mixed-impairment paratriathletes during competition in a hot environment (33°C, 35-41% relative humidity, 25-27°C water temperature), via an ingestible temperature sensor (BodyCap e-Celsius). Furthermore, in a subset of 9 athletes, skin temperature (Tsk) was measured. Athletes' wetsuit use was noted whilst heat illness symptoms were self-reported post-race. RESULTS Twenty-two athletes displayed a Tc ≥39.5°C with 8 athletes ≥40.0°C. There were increases across the average Tc for swim, bike and run sections (p≤0.016). There was no change in Tsk during the race (p≥0.086). Visually impaired athletes displayed a significantly greater Tc during the run section than athletes in a wheelchair (p≤0.021). Athletes wearing a wetsuit (57% athletes) had a greater Tc when swimming (p≤0.032) whilst those reporting heat illness symptoms (57% athletes) displayed a greater Tc at various timepoints (p≤0.046). CONCLUSIONS Paratriathletes face significant thermal strain during competition in the heat, as evidenced by high Tc, relative to previous research in able-bodied athletes, and a high incidence of self-reported heat illness symptomatology. Differences in the Tc profile exist depending on athletes' race category and wetsuit use.
Species interactions affect the spread of vector-borne plant pathogens independent of transmission mode.

Within food webs, vectors of plant pathogens interact with individuals of other species across multiple trophic levels, including predators, competitors, and mutualists. These interactions may in turn affect vector-borne pathogens by altering vector fitness and behavior. Predators, for example, consume vectors and reduce their abundance, but often spur movement of vectors as they seek to avoid predation. However, a general framework to predict how species interactions affect vectors of plant pathogens, and the resulting spread of vector-borne pathogens, is lacking. Here we developed a mathematical model to assess whether interactions such as predation, competition, and mutualism affected the spread of vector-borne plant pathogens with non-persistent or persistent transmission modes. We considered transmission mode because interactions affecting vector-host encounter rates were expected to most strongly affect non-persistent pathogens that are transmitted with short feeding bouts; interactions that affect vector feeding duration were expected to most strongly affect persistent pathogens that require long feeding bouts for transmission. Our results show that interactions that affected vector behavior (feeding duration, vector-host encounter rates) substantially altered rates of spread for vector-borne plant pathogens, while those affecting vector fitness (births, deaths) had relatively small effects. These effects of species interactions were largely independent of transmission mode, except when interactions affected vector-host encounter rates, where effects were strongest for non-persistent pathogens. Our results suggest that a better understanding of how vectors interact with other species within food webs could enhance our understanding of disease ecology. This article is protected by copyright. All rights reserved.
Indirect Effects of Early Parenting on Adult Antisocial Outcomes via Adolescent Conduct Disorder Symptoms and Callous-Unemotional Traits

Parental harsh punishment and warmth have been associated with child and adolescent conduct disorder (CD) symptoms and callous-unemotional (CU) traits (i.e., lack of guilt, empathy, and deficient affect); however, it is unclear whether the effect of these parenting behaviors on antisocial outcomes persists into adulthood. Thus, the present study aimed to test whether adolescent CD symptoms and CU traits mediate the effect of parental harsh punishment and warmth on adult antisocial outcomes (i.e., antisocial personality disorder (ASPD), externalizing psychopathology, partner violence, and violent and substance crime). Participants included the high-risk control and normative samples from the Fast Track project (N =753, male = 58%, African American = 46%). Harsh punishment during kindergarten through grades 1–2 predicted higher adolescent CD symptoms, and directly observed warmth during kindergarten through grades 1–2 predicted lower adolescent CU traits. Adolescent CD symptoms predicted greater adult substance crime, and adolescent CU traits predicted greater adult ASPD symptoms and externalizing psychopathology. Further, adolescent CD symptoms indirectly accounted for the effect of parental harsh punishment on adult substance crime, and adolescent CU traits indirectly accounted for the effect of parental warmth on ASPD symptoms and externalizing psychopathology. Findings support the importance of early interventions targeting parenting behaviors to reduce risk for the development of antisocial behavior, and inform developmental models of antisocial behavior in adolescence through adulthood.
Identification and characterization of a murine model of BCR-ABL1+ acute B-lymphoblastic leukemia with central nervous system metastasis

Breakpoint cluster region (BCR)-Abelson murine leukemia (ABL)1+ acute B-lymphoblastic leukemia (B-ALL) is a disease associated with a dismal prognosis and a high incidence of central nervous system (CNS) metastasis. However, BCR-ABL1+ B-ALL with CNS infiltration has not been previously characterized, at least to the best of our knowledge. In the present study, a murine model of BCR-ABL1+ B-ALL with CNS metastasis was established using retroviral transduction. The vast majority of BCR-ABL1+ leukemic cells were found to be immature B cells with a variable proportion of pro-B and pre-B populations. The present results indicated that the BCR-ABL1+ B-leukemic cells expressed high levels integrin subunit alpha 6 (Itga6) and L-selectin adhesion molecules, and have an intrinsic ability to disseminate and accumulate in CNS tissues, predominantly in meninges. On the whole, these results provide an approach for addressing the mechanisms of BCR-ABL1+ B-ALL with CNS metastasis and may guide the development of novel therapeutic strategies.
Neuropsychological dysfunction in chronic fatigue syndrome and the relation between objective and subjective findings.

OBJECTIVE This study aimed to explore the relationship between self-reported cognitive difficulties, objective neuropsychological test performances, and subjective health complaints in chronic fatigue syndrome (CFS) and to examine the degree of impaired cognitive functions. METHOD A total of 236 consecutively recruited outpatients, 18-62 years of age, completed the tests. Self-administered questionnaires were used for assessing fatigue, pain, depression, anxiety and subjective cognitive complaints (Everyday Memory Questionnaire [EMQ]). Also, neuropsychological tests, that is, Stroop I-IV, California Verbal Learning Test-Second Edition (CVLT-II) learning and delay, Wechsler Adult Intelligence Scale-Third Edition (WAIS-III) Letter Number (L-N) Sequencing, and the Paced Auditory Serial Addition Task were performed to examine whether these objective measures correlated with subjective complaints and were compared with normative data. RESULTS There was a trend of association (p < .05) between the unadjusted EMQ with Stroop IV (inhibition and shifting attention), the CVLT-II learning and delay (verbal learning and memory), and the WAIS-III L-N Sequencing (working memory), but none were statistically significant at the . 001 level. The EMQ was positively associated with fatigue, pain, and depression (p < .001). The PASAT (working memory) was negatively associated with pain (p < .001). Between 21% and 38% of the patients performed below the 1.5-SD cutoff for clinically significant impairment on the Stroop tests. CONCLUSION The self-reported cognitive performance was not strongly associated with the objective cognitive performances on any domains in patients with CFS. Patients with higher fatigue, pain, and depression levels reported greater subjective cognitive difficulties, as well as higher pain related to lower objective working memory function. The CFS patients had problems mainly in the domains of psychomotor speed and attention measured by the objective neuropsychological tests. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
Biofibre® artificial hair implant: Retrospective study on 1,518 patients with alopecia and present role in hair surgery

To treat alopecia, there are many surgical and nonsurgical treatments available nowadays. In the surgical one, the Biofibre® hair implantation system represents an important innovation with artificial hair with special physical, chemical, and mechanical features and the new Biofibre® Automatic device. Implant on 1,518 patients has been reported in this study where the Biofibre® hair implant technique is performed on men and women with varying degrees of baldness and for the treatment of various causes of alopecia such as androgenetic alopecia, burns, and scars. According to our experience, this technique gives immediate and visible results without scarring or hospitalization and the aesthetic results are very encouraging for both male and female patients with a rapid recovery of self‐esteem and psychological well‐being.
Is self-esteem associated with self-rated health among French college students? A longitudinal epidemiological study: the i-Share cohort

Objectives The aim of the study was to estimate the association between self-esteem and subsequent self-rated health during college years, taking into account a wide range of potential confounders. Design Prospective longitudinal study. Setting The French i-Share cohort. Participants The sample consisted of 1011 college students. Primary and secondary outcome measures The association between self-esteem and later self-rated health was evaluated using multivariate modelling. Data regarding self-rated health, global self-esteem and demographic, educational, social, behavioural, environmental and financial characteristics were collected through an internet-based questionnaire. Results The 1011 participants had a median age of 21.9 years and 79% (795/1011) were females. Self-rated health was assessed a median of 8 months after the self-esteem measurement. Twenty per cent of the students declared average to very poor health (203/1011). Students with higher levels of self-esteem were more likely to declare good or very good self-rated health (adjusted OR=1.40, 95% CI 1.15 to 1.72, p value=0.001). Other factors associated with good or very good self-rated health were low body mass index, a comfortable financial situation during childhood and three personality traits (low persistence and harm avoidance and high cooperativeness). Conclusions This study offers novel findings on the impact of self-esteem on self-rated health among college students. Interventions targeting self-esteem should be experimented during university years in order to improve health outcomes.
On construction of single‐arm two‐stage designs with consideration of both response and toxicity

When establishing a treatment in clinical trials, it is important to evaluate both effectiveness and toxicity. In phase II clinical trials, multinomial data are collected in m‐stage designs, especially in two‐stage ( m=2 ) design. Exact tests on two proportions, pr for the response rate and pt for the nontoxicity rate, should be employed due to limited sample sizes. However, existing tests use certain parameter configurations at the boundary of null hypothesis space to determine rejection regions without showing that the maximum Type I error rate is achieved at the boundary of null hypothesis. In this paper, we show that the power function for each test in a large family of tests is nondecreasing in both pr and pt ; identify the parameter configurations at which the maximum Type I error rate and the minimum power are achieved and derive level‐α tests; provide optimal two‐stage designs with the least expected total sample size and the optimization algorithm; and extend the results to the case of m>2 . Some R‐codes are given in the Supporting Information.
MicroRNA-802 increases hepatic oxidative stress and induces insulin resistance in high-fat fed mice

The expression of microRNA-802 (miR-802) is known to be associated with insulin resistance (IR); however, the mechanism remains unclear. The present study investigated how miR-802 contributes to the development of IR using C57BL/6J mice fed a high-fat diet (HFD) to establish a model of IR. Adeno-associated virus overexpressing miR-802 was administered to the mice via tail vein injection. The effects of miR-802 on reactive oxygen species (ROS), lipid peroxidation (LPO) and the activities of multiple ROS-related enzymes were investigated. Western blot analysis was used to estimate the protein levels of extracellular signal regulated kinase (ERK), p38mitogen-activated protein kinases (p38MAPK), c-Jun N-terminal kinase (JNK), insulin receptor substrate 1 (IRS-1) and protein kinase B (AKT1). The results demonstrated that the levels of ROS and LPO production were increased in the livers of the miR-802-treated group compared with the control group. The activities of the ROS-related enzymes were reduced. Furthermore, the expression of phosphorylated (phosphor)-p38MAPK and phosphor-JNK were upregulated in the miR-802 overexpression group, whereas there was no difference in the expression levels of phosphor-ERK. The expression levels of phosphor-AKT1 were reduced in the miR-802-treated group and these effects were reversed by miR-802 knockdown. In conclusion, the results demonstrate that miR-802 may cause IR by activating the JNK and p38MAPK pathways to increase hepatic oxidative stress.
Rotational Thromboelastometry or Conventional Coagulation Tests in Liver Transplantation: Comparing Blood Loss, Transfusions, and Cost.

INTRODUCTION Orthotopic liver transplantation (OLT) can be associated with significant bleeding requiring multiple blood product transfusions. Rotational thromboelastometry (ROTEM) is a point-of-care device that has been used to monitor coagulation during OLT. Whether it reduces blood loss/transfusions during OLT remains controversial. MATERIALS AND METHODS We aim to compare ROTEM with conventional coagulation tests (aPTT, PT, INR, platelet count, fibrinogen) to guide transfusion of platelets, cryoprecip-itate, and fresh frozen plasma (FFP) during OLT over 3 years. Thirty-four patients who had transfusions guided by ROTEM were compared to 34 controls who received transfusions guided by conventional coagulation tests (CCT). Intraoperative blood loss, type/ amount of blood products transfused, and direct costs were compared between the two groups. RESULTS The ROTEM group had significantly less intra-operative blood loss (2.0 vs. 3.0 L, p = 0.04) and fresh frozen plasma (FFP) transfusion (4 units vs. 6.5 units, p = 0.015) compared to the CCT group (2.0L vs. 3.0L, p = 0.04). However, total number of patients transfused cryoprecipitate was increased in ROTEM (n = 25;73%) as compared to CCT (n = 19; 56%), p = 0.033. The direct cost of blood products plus testing was reduced in the ROTEM group ($113,142.89 vs. $127,814.77). CONCLUSION In conclusion implementation of a ROTEM-guided transfusion algorithm resulted in a reduction in intra-operative blood loss, FFP transfusion and a decrease in direct cost during OLT. ROTEM is a useful and safe point of care device in OLT setting.
ON THE CORNEAL SENSITIVITY

Clinical and theoretical interest in corneal sensitivity and its qualities was already alive at the end of the last century (Molter 1878, Fuchs 1878, Desoir 1892) but no exact or comparable measurements were available until von Frey introduced his hair method for exact measurements of tactile sensibility in 1894. Von Frey's method was simple. By wax or glue he fixed a hair at a right angle to the end of a short stick. When such a hair is pressed at right angles against a surface until the hair just bends, the pressure exerted, under these conditions, depends only on the length, the calibre and the elasticity of the hair. This last depends on the type, the moisture-content, and the age of the hair, while the temperature probably is of no significance. The power of the hair is expressed as the greatest pressure the hair is able to stand when just bending. Von Frey's work concerned the cutaneous sensitivity generally and, as part of this subject, his interest was directed towards the sensitivity of the cornea. He held the opinion that the cornea possessed only the sense of pain. Several authors (v. Frey, 1894, 1897, v. Frey & Webels, 1922, and others) were interested in the problems of corneal sensitivity, but opinions differ on the question as to whether only pain-sensitivity is found or if tactile sensitivity is also present. I t seems to be agreed that cold-sensitivity is present only in the peripheral zone of the cornea. I t might be of interest to mention the results of the Sjogren (1938) experiments with tractotomy, by which he proved that pain sensibility could be abolished while still preserving tactile sensibility in the cornea. I t seems to be very difficult to agree as to whether the feeling of touch is elicited by a lesser stimulus of the pain nerves or whether the sensation of touch must be ascribed to a special sense located either in the corneal nerve endings or in the brain stem (Rodger 1953).