Miracle-dz/UniFAR-FTUs huggingface dataset:
On Achievable Rate of User Selection for MIMO Broadcast Channels With Limited Feedback

We consider the block diagonalization (BD) and user selection based on limited feedback in multiple antenna broadcast channels. With limited feedback, due to the imperfect channel state information at the transmitter (CSIT), BD cannot completely eliminate multiuser interference, and the throughput is correspondingly lower than that achieved with perfect CSIT. Nevertheless, the achievable multiuser diversity gain can be the same, such that limited-feedback-based BD can achieve an optimal throughput growth as the number of users increases. To show this, we first propose a channel quality indicator (CQI) for user selection. The CQI is designed to accurately estimate an achievable rate of each user and is given by an expected rate, where the expectation is solely taken over precoding matrices which cannot be known at the feedback stage. With the proper CQI, user selection can benefit from a large number of users in the system. As a result, we show that the BD can achieve an asymptotically optimal growth in throughput with the proposed CQI, based solely on a finite-rate feedback of channel information.
LDplayer: DNS Experimentation at Scale

DNS has evolved over the last 20 years, improving in security and privacy and broadening the kinds of applications it supports. However, this evolution has been slowed by the large installed base and the wide range of implementations. The impact of changes is difficult to model due to complex interactions between DNS optimizations, caching, and distributed operation. We suggest that experimentation at scale is needed to evaluate changes and facilitate DNS evolution. This paper presents LDplayer, a configurable, general-purpose DNS experimental framework that enables DNS experiments to scale in several dimensions: many zones, multiple levels of DNS hierarchy, high query rates, and diverse query sources. LDplayer provides high fidelity experiments while meeting these requirements through its distributed DNS query replay system, methods to rebuild the relevant DNS hierarchy from traces, and efficient emulation of this hierarchy on minimal hardware. We show that a single DNS server can correctly emulate multiple independent levels of the DNS hierarchy while providing correct responses as if they were independent. We validate that our system can replay a DNS root traffic with tiny error (± 8 ms quartiles in query timing and ± 0.1% difference in query rate). We show that our system can replay queries at 87k queries/s while using only one CPU, more than twice of a normal DNS Root traffic rate. LDplayer's trace replay has the unique ability to evaluate important design questions with confidence that we capture the interplay of caching, timeouts, and resource constraints. As an example, we demonstrate the memory requirements of a DNS root server with all traffic running over TCP and TLS, and identify performance discontinuities in latency as a function of client RTT.
Properties of excitatory postsynaptic currents recorded in vitro from rat hippocampal interneurones.

1. We studied excitatory synaptic currents activated by stimulation of Schaffer collateral‐commissural fibres and recorded from interneurones in the CA1 region of hippocampal slices using whole‐cell techniques. 2. Interneurones were identified by their location outside the cell layer and their morphology as seen with differential interference contrast (DIC) microscopy and by filling with Lucifer Yellow (LY). 3. The excitatory postsynaptic current (EPSC) had a fast, voltage‐insensitive component and a slow component which had a region of negative slope resistance between ‐70 and ‐40 mV. The slow voltage‐dependent component was abolished by the N‐methyl‐D‐aspartate (NMDA) receptor antagonist (DL‐2‐amino‐5‐phosphonovalerate (APV) 50 microM) which had little effect on the fast component. Conversely, the fast component was abolished by the non‐NMDA receptor antagonist 6‐cyano‐7‐nitoquinoxaline‐2,3‐dione (CNQX; 10 microM), which had no effect on the slow component. 4. The rise time of the fast component ranged from 1 to 3 ms and the decay time constant ranged from 3 to 15 ms. The rise time of the slow component ranged from 5 to 11 ms and the decay time constant ranged from 50 to 100 ms. 5. It is concluded that although the morphology of the excitatory synapses onto interneurones differs considerably from those onto pyramidal cells, their electrophysiological and pharmacological properties are very similar.
Direct measurement of transient pulses induced by laser and heavy ion irradiation in deca-nanometer devices

This paper investigates the transient response of 50-nm gate length fully and partially depleted SOI and bulk devices to pulsed laser and heavy ion microbeam irradiations. The measured transient signals on 50-nm fully depleted devices are very short, and the collected charge is small compared to older 0.25-/spl mu/m generation SOI and bulk devices. We analyze in detail the influence of the SOI architecture (fully or partially depleted) on the pulse duration and the amount of bipolar amplification. For bulk devices, the doping engineering is shown to have large effects on the duration of the transient signals and on the charge collection efficiency.
Obesity and Cardiovascular Disease Risk: Research Update

The obesity epidemic has reached unprecedented proportions in Western society. Evidence continues to accumulate that obesity is associated with significant morbidity and mortality and in particular that it is an independent risk factor for cardiovascular disease (CVD). The association of obesity with CVD and its risk factors, including hypertension, dyslipidemia, glucose intolerance, and impaired hemostasis is becoming more clearly understood. An increasing body of data indicates that risk factors tend to cluster in obese individuals and may act synergistically to increase these people’s risk for CVD. Individuals with disproportionate visceral adiposity are at significantly greater risk for CVD. Adult weight gain also underlies the development of many risk factors and augments the risk of CVD. Physicians can play a vital and active role in the prevention and treatment of obesity and overweight and thereby reduce patients’ CVD risk.
A psychotechnological review on eye-tracking systems: towards user experience

Purpose: The aim of the present work is to show a critical review of the international literature on eye-tracking technologies by focusing on those features that characterize them as ‘psychotechnologies’. Method: A critical literature review was conducted through the main psychology, engineering, and computer sciences databases by following specific inclusion and exclusion criteria. A total of 46 matches from 1998 to 2010 were selected for content analysis. Results have been divided into four broad thematic areas. Results: We found that, although there is a growing attention to end-users, most of the studies reviewed in this work are far from being considered as adopting holistic human-computer interaction models that include both individual differences and needs of users. User is often considered only as a measurement object of the functioning of the technological system and not as a real alter-ego of the intrasystemic interaction. Conclusion: In order to fully benefit from the communicative functions of gaze, the research on eye-tracking must emphasize user experience. Eye-tracking systems would become an effective assistive technology for integration, adaptation and neutralization of the environmental barrier only when a holistic model can be applied for both design processes and assessment of the functional components of the interaction. Implications for Rehabilitation Eye-tracking methodologies facilitates communicative functions of gaze favoring a successful outcome in many areas of rehabilitation. Eye-tracking systems would be an effective assistive technology for integration, adaptation and neutralization of the environmental barrier. Successful rehabilitation outcomes are improved when a holistic and interactive model is applied for both design processes and assessment of the functional components of the interaction.
Photoassisted Oxidation of Sulfides Catalyzed by Artificial Metalloenzymes Using Water as an Oxygen Source

The Mn(TpCPP)-Xln10A artificial metalloenzyme, obtained by non-covalent insertion of Mn(III)-meso-tetrakis(p-carboxyphenyl)porphyrin [Mn(TpCPP), 1-Mn] into xylanase 10A from Streptomyces lividans (Xln10A) as a host protein, was found able to catalyze the selective photo-induced oxidation of organic substrates in the presence of [RuII(bpy)3]2+ as a photosensitizer and [CoIII(NH3)5Cl]2+ as a sacrificial electron acceptor, using water as oxygen atom source.
Evaluación neuropsicológica en mujeres víctimas de violencia de género

[ES]El maltrato hacia la mujer es un grave problema en la sociedad actual que repercute en un deterioro de la calidad de vida de las victimas a nivel fisico, psiquico y social. Las investigaciones realizadas con mujeres maltratadas se han centrado en los trastornos psicologicos que provocan (depresion, ansiedad, TEP. etc.) y en los sintomas fisicos y psiquicos que estas mujeres presentan (dolores de cabeza, perdida de memoria, falta de atencion, somatizaciones, etc.). Esta investigacion se ha centrado en poder demostrar, que cualquier tipo de violencia ejercida hacia la mujer de manera continuada produce un deterioro cognitivo. Este estudio se realizo, con una muestra total de 136 participantes, 68 mujeres victimas de maltrato comparandolas con otras 68 mujeres que no habian sufrido violencia. Como instrumento de evaluacion neuropsicologica se ha utilizado la bateria Luria DNA. Diagnostico neuropsicologico de adultos (Manga y Ramos 2000) y el Cuestionario semi-estructurado de evaluacion del maltrato (Perez, Torres, Velasco, Conde y Garcia 2005) elaborado para dicha investigacion. Los resultados senalan que las mujeres victimas de maltrato presentan un menor rendimiento en la ejecucion de la bateria Luria DNA, por lo que tenemos la evidencia de que el maltrato repercute a nivel neuropsicologico (deficit de atencion, memoria, lenguaje, etc.). A pesar de que los resultados apuntan a que el tiempo de exposicion al maltrato no influye en las secuelas neuropsicologicas, este resultado hay que tomarlo con cautela, era de esperar que a medida que la exposicion al maltrato es mas prolongada las puntuaciones serian mas bajas, en contra de los esperado, las mayores puntuaciones en la Bateria Luria DNA se detectan en el grupo de mujeres que permanecen en la situacion de maltrato entre los cinco y los diez anos, en las mujeres que han sufrido el maltrato desde el inicio hasta los cuatro anos puntuan mas bajo y las que lo sufren mas de diez anos puntuan mucho mas bajo, esto hace que nos planteemos que estan influyendo variables de tipo emocional pero que no podemos asegurar en nuestra investigacion. Por otra parte, es importante disponer de una red social, se ha podido demostrar que tambien influye en el rendimiento neuropsicologico, aunque no hay diferencias en el tipo de apoyo que sea, lo importante es que exista. Seria importante continuar con esta linea de investigacion neuropsicologica debido a que los estudios son inexistentes y pueden ser de gran importancia para los profesionales de diversa areas como puede ser: apoyar los diagnosticos, las intervenciones terapeuticas e incluso para realizar peritajes
Effects of physiological hyperglycemia on duodenal motility and flow events, glucose absorption, and incretin secretion in healthy humans.

CONTEXT Acute hyperglycemia slows gastric emptying, but its effects on small intestinal motor activity and glucose absorption are unknown. In type 2 diabetes, the postprandial secretion of glucose-dependent insulinotropic polypeptide (GIP) is preserved, but that of glucagon-like peptide-1 (GLP-1) is possibly reduced; whether the latter is secondary to hyperglycemia or diabetes per se is unknown. AIM The aim was to investigate the effects of acute hyperglycemia on duodenal motility and flow events, glucose absorption, and incretin hormone secretion. METHODS Nine healthy volunteers were studied on two occasions. A combined manometry/impedance catheter was positioned in the duodenum. Blood glucose was clamped at either 9 mmol/liter (hyperglycemia) or 5 mmol/liter (euglycemia) throughout the study. Manometry and impedance recordings continued between T=-10 min and T=180 min. Between T=0 and 60 min, an intraduodenal glucose infusion was given (approximately 3 kcal/min), together with 14C-labeled 3-O-methylglucose (3-OMG) to evaluate glucose absorption. RESULTS Hyperglycemia had no effect on duodenal pressure waves or flow events during the 60 min of intraduodenal glucose infusion, when compared to euglycemia. During hyperglycemia, there was an increase in plasma GIP (P<0.05) and 14C-3-OMG (P<0.05) but no effect on GLP-1 concentrations in response to the intraduodenal infusion, compared to euglycemia. CONCLUSION Acute hyperglycemia in the physiological range has no effect on duodenal pressure waves and flow events but is associated with increased GIP secretion and rate of glucose absorption in response to intraduodenal glucose.
Her-2/neu and INT2 proto-oncogene amplification in malignant breast tumors in relation to reproductive factors and exposure to exogenous hormones.

In previous studies in southern Sweden, early use of oral contraceptives has been found to be accompanied by an increased risk of developing premenopausal breast cancer, and the tumors developing in these patients have shown a more aggressive behavior. In the present study, amplification of the proto-oncogenes Her-2/neu (also known as ERBB2) and INT2 was studied in primary tumor specimens from 72 premenopausal women and was related to starting age of oral contraceptive use and other reproductive risk factors. Amplification of Her-2/neu was more common among early oral contraceptive users (i.e., those starting at less than or equal to 20 years of age) than among nonusers or late users (odds ratio [OR], 5.3; 95% confidence interval [CI], 1.6-16.7), whereas INT2 amplification did not differ significantly among those groups (OR, 0.9; 95% CI, 0.1-5.0). The likelihood of INT2 amplification was greater among users of progestins and those with a history of abortions before the first full-term pregnancy (OR, 9.0; 95% CI, 1.3-51.7; and OR, 18.6; 95% CI, 2.2-165.8, respectively). No significant relationships were found between proto-oncogene amplification and the variables of parity, age at first full-term pregnancy, or late abortion. The increased ORs persisted after adjustment for age at diagnosis and other risk factors. The findings suggest that the higher rate of Her-2/neu amplification among early oral contraceptive users is an effect of the oral contraceptive use per se rather than of the relative youth of the users. Moreover, the relationship between progestin use and early abortion and amplification of the INT2 gene is biologically plausible.
Pre-morbid human T-lymphotropic virus type I proviral load, rather than percentage of abnormal lymphocytes, is associated with an increased risk of aggressive adult T-cell leukemia/lymphoma

Out of 153 newly referred human T-lymphotropic virus type I infected patients, 42 (27%) had 5% or more abnormal lymphocytes, consistent with the diagnosis of smoldering adult T-cell leukemia/lymphoma. The abnormal lymphocyte percentage was higher in patients with human T-lymphotropic virus type I associated inflammatory disease compared with asymptomatic carriers (P=0.006). Over 4.5 years median follow up, 4 patients, all with 10 or more human T-lymphotropic virus type I DNA copies/100 peripheral blood mononuclear cells at presentation, but only one with 5% or more abnormal lymphocytes at presentation, developed adult T-cell leukemia/lymphoma. Thus, high pre-morbid human T-lymphotropic virus type I proviral load, rather than fulfilment of the classification criteria for smoldering adult T-cell leukemia/lymphoma, was associated with an increased risk of developing aggressive adult T-cell leukemia/lymphoma.
CURRENT MANAGEMENT OF PEPTIC ULCER PERFORATIONS

Perforation is a life-threatening complication of peptic ulcer disease. Smoking and use of non-steroidal anti-inflammatory drugs are important risk factors for perforation. Diagnosis is made clinically and confirmed by the presence of pneumoperitoneum on radiographs. Nonoperative management is successful in patients identified to have a spontaneously sealed perforation proven by water-soluble contrast gastroduodenogram. Operative management consists of the time-honoured practice of omental patch closure, but now this can be done by laparoscopic methods. The practice of addition of acid-reducing procedures is currently being debated though it continues to be recom- mended in good-risk patients. Laparoscopic approaches to closure of duodenal perforation are now being applied widely and may become the gold standard in the future especially in patients with <10mm perforation size presenting within the first 24 hours of onset of pain. The role of Helicobacter pylori in duodenal ulcer perforation is controversial and more studies are needed to answer this question though recent indirect evidence suggests that eradicating H pylori may reduce the necessity for adding acid reducing procedures and the associated morbidity. Perforation is a life-threatening complication of peptic ulcer disease. The management of peptic ulcer disease has evolved over the decades, due to advances in operative techniques, bacteriology and pharmacology. While the recognition of the role of Helicobacter pylori (H. pylori) in peptic ulcer- ation has resulted in a paradigm shift in the management of uncomplicated peptic ulcers, debate continues about the appropriate management of perforated duodenal bulb and prepyloric ulcers. A new dimension has been added to this controversy by the advent of laparoscopic techniques for closing the perforation. A medline search of all articles dealing with the management of peptic ulcer perforation published after 1985 was undertaken. The shortlisted articles were analysed and studies which were well designed and had important inferences were selected. Based on these inferences, the controversies surrounding the management of peptic ulcer perforation have been discussed in this review article.
Regulation of Type VI Secretion Gene Clusters by σ54 and Cognate Enhancer Binding Proteins

ABSTRACT Type VI secretion systems (T6SS) are bacteriophage-derived macromolecular machines responsible for the release of at least two proteins in the milieu, which are thought to form an extracellular appendage. Although several T6SS have been shown to be involved in the virulence of animal and plant pathogens, clusters encoding these machines are found in the genomes of most species of Gram-negative bacteria, including soil, marine, and environmental isolates. T6SS have been associated with several phenotypes, ranging from virulence to biofilm formation or stress sensing. Their various environmental niches and large diversity of functions are correlated with their broad variety of regulatory mechanisms. Using a bioinformatic approach, we identified several clusters, including those of Vibrio cholerae, Aeromonas hydrophila, Pectobacterium atrosepticum, Pseudomonas aeruginosa, Pseudomonas syringae pv. tomato, and a Marinomonas sp. , which possess typical −24/−12 sequences, recognized by the alternate sigma factor sigma 54 (σ54 or σN). σ54, which directs the RNA polymerase to these promoters, requires the action of a bacterial enhancer binding protein (bEBP), which binds to cis-acting upstream activating sequences. Putative bEBPs are encoded within the T6SS gene clusters possessing σ54 boxes. Using in vitro binding experiments and in vivo reporter fusion assays, we showed that the expression of these clusters is dependent on both σ54 and bEBPs.
Towards Scalable Hybrid Stores: Constraint-Based Rewriting to the Rescue

Big data applications routinely involve diverse datasets: relations flat or nested, complex-structure graphs, documents, poorly structured logs, or even text data. To handle the data, application designers usually rely on several data stores used side-by-side, each capable of handling one or a few data models, and each very efficient for some, but not all, kinds of processing on the data. A current limitation is that applications are written taking into account which part of the data is stored in which store and how. This fails to take advantage of (i) possible redundancy, when the same data may be accessible (with different performance) from distinct data stores; (ii) partial query results (in the style of materialized views) which may be available in the stores. We present ESTOCADA, a novel approach connecting applications to the potentially heterogeneous systems where their input data resides. ESTOCADA can be used in a polystore setting to transparently enable each query to benefit from the best combination of stored data and available processing capabilities. ESTOCADA leverages recent advances in the area of view-based query rewriting under constraints, which we use to describe the various data models and stored data. Our experiments illustrate the significant performance gains achieved by ESTOCADA.
Combining 123I-Metaiodobenzylguanidine SPECT/CT and 18F-FDG PET/CT for the Assessment of Brown Adipose Tissue Activity in Humans During Cold Exposure

Brown adipose tissue (BAT) has become a focus of research in the hope of finding a new target to fight obesity. Metabolic BAT activity can be visualized with 18F-FDG PET/CT. Furthermore, the sympathetic innervation of BAT can be visualized with the radiolabeled norepinephrine analog 123I-metaiodobenzylguanidine (123I-MIBG). We aimed to determine whether 123I-MIBG SPECT/CT and 18F-FDG PET/CT identify the same anatomic regions as active BAT in adult humans. Furthermore, we investigated whether the magnitude of BAT activity measured by these techniques correlated. Finally, we tried to establish the optimal time interval between 123I-MIBG administration and subsequent SPECT/CT acquisition to visualize sympathetic stimulation of BAT. Methods: Ten lean (body mass index, 19–25 kg/m2), healthy Caucasian men (age, 18–32 y) underwent one 18F-FDG PET/CT and two 123I-MIBG-SPECT/CT scans within a 2-wk interval. On 2 separate occasions, the subjects were exposed to mild cold (17°C) for 2 h after an overnight fast. After 1 h of cold exposure, 18F-FDG (one occasion) or 123I-MIBG (other occasion) was administered. 18F-FDG PET/CT was performed at 1 h after 18F-FDG administration, and 123I-MIBG-SPECT/CT was performed at 4 and 24 h after 123I-MIBG injection. Results: 18F-FDG uptake in BAT was observed in 8 of 10 subjects, whereas 123I-MIBG uptake was observed in 7 of 10 subjects in both the SPECT/CT scans acquired at 4 h after 123I-MIBG administration and the SPECT/CT scans acquired at 24 h after 123I-MIBG administration. All subjects who showed 123I-MIBG uptake in BAT also showed 18F-FDG uptake in BAT. There was no statistically significant correlation between maximal standardized uptake value of 18F-FDG and semiquantitative uptake of 123I-MIBG at 4 h after administration. However, a positive correlation was found between the maximal standardized uptake value of 18F-FDG and semiquantitative uptake of 123I-MIBG at 24 h after administration (r = 0.64, P = 0.04). Conclusion: 123I-MIBG SPECT/CT, as a marker of sympathetic activity, and 18F-FDG PET/CT, as a marker of metabolic activity, identified the same anatomic regions as active BAT. Moreover, when 123I-MIBG SPECT/CT was performed at 24 h after 123I-MIBG administration, the magnitude of BAT activity measured with these techniques correlated strongly. This finding not only supports that BAT activity in humans is sympathetically influenced but also identifies 123I-MIBG SPECT/CT, when performed 24 h after 123I-MIBG injection, as a method to visualize and quantify sympathetic stimulation of BAT.