Miracle-dz/UniFAR-FTUs huggingface dataset:
Perceiving Happiness in an Intergroup Context: The Role of Race and Attention to the Eyes in Differentiating Between True and False Smiles

The present research comprises six experiments that investigated racial biases in the perception of positive emotional expressions. In an initial study, we demonstrated that White participants distinguished more in their happiness ratings of Duchenne (“true”) and non-Duchenne (“false”) smiles on White compared with Black faces (Experiment 1). In a subsequent study we replicated this effect using a different set of stimuli and non-Black participants (Experiment 2). As predicted, this bias was not demonstrated by Black participants, who did not significantly differ in happiness ratings between smile types on White and Black faces (Experiment 3). Furthermore, in addition to happiness ratings, we demonstrated that non-Black participants were also more accurate when categorizing true versus false expressions on White compared with Black faces (Experiment 4). The final two studies provided evidence for the mediating role of attention to the eyes in intergroup emotion identification. In particular, eye tracking data indicated that White participants spent more time attending to the eyes of White than Black faces and that attention to the eyes predicted biases in happiness ratings between true and false smiles on White and Black faces (Experiment 5). Furthermore, an experimental manipulation focusing participants on the eyes of targets eliminated the effects of target race or perceptions of happiness (Experiment 6). Together, the findings provide novel evidence for racial biases in the identification of positive emotions and highlight the critical role of visual attention in this process.
Nonlinear optical organic-inorganic crystals: synthesis, structural analysis and verification of harmonic generation in tri-(o-chloroanilinium nitrate).

The structural and nonlinear optical properties of a new anilinium hybrid crystal of chemical formula (C6H7NCl+·NO3-)3 have been investigated. The crystal structure was determined from single-crystal X-ray diffraction measurements performed at a temperature of 100 K which show that the compound crystallizes in a noncentrosymmetric space group (Pna21). The structural analysis was coupled with Hirshfeld surface analysis to evaluate the contribution of the different intermolecular interactions to the formation of supramolecular assemblies in the solid state that exhibit nonlinear optical features. This analysis reveals that the studied compound is characterized by a three-dimensional network of hydrogen bonds and the main contributions are provided by the O.H, C.H, H.H and Cl.H interactions, which alone represent ∼85% of the total contributions to the Hirshfeld surfaces. It is noteworthy that the halogen.H contributions are quite comparable with those of the H.H contacts. The nonlinear optical properties were investigated by nonlinear diffuse femtosecond-pulse reflectometry and the obtained results were compared with those of the reference material LiNbO3. The hybrid crystals exhibit notable second (SHG) and third (THG) harmonic generation which confirms its polarity is generated by the different intermolecular interactions. These measurements also highlight that the THG signal of the new anilinium compound normalized to its SHG counterpart is more pronounced than for LiNbO3.
A Role for Orexin Neuron Activity in Cytotoxic Chemotherapy-Induced Fatigue

Background Fatigue is the most common symptom related to cytotoxic chemotherapeutic treatment of cancer. Peripheral inflammation associated with cytotoxic chemotherapy is likely a causal factor of fatigue. However, the neural mechanisms by which cytotoxic chemotherapy associated inflammation induces fatigue behavior are not known. This lack of knowledge hinders development of interventions to reduce or prevent this disabling symptom. Infection induced fatigue/lethargy in rodents is mediated by suppression of hypothalamic orexin signaling. Orexin is critical for maintaining wakefulness and motivated behavior. Although there are differences between infection and cytotoxic chemotherapy in some symptoms, both induce peripheral inflammation and fatigue. These similarities formed the basis of my hypothesis that cytotoxic chemotherapy induces fatigue by disrupting orexin signaling. Methods A cytotoxic chemotherapy cocktail (cyclophosphamide, adriamycin, 5fluorouracil—CAF) commonly used to treat breast cancer was administered to mice and rats. Fatigue was measured by a decrease in voluntary ambulatory and wheel running activity, measured by telemetry. Reverse transcription real-time PCR was used to measure inflammatory gene expression in the hypothalamus and brainstem. Hypothalamic orexin neuron activity was determined with immunohistochemical examination of nuclear cFos localization and measurement of cerebrospinal fluid levels of orexin-A. Exogenous orexin-A neuropeptide was administered through a
Does having a rotator cuff repair prior to reverse total shoulder arthroplasty influence the outcome?

Aims The number of rotator cuff repairs that are undertaken is increasing. Reverse shoulder arthroplasty (RSA) is the procedure of choice for patients with rotator cuff arthropathy. We sought to determine whether patients who underwent rotator cuff repair and subsequent RSA had different outcomes compared with a matched control group who underwent RSA without a previous rotator cuff repair. Patients and Methods All patients with a history of rotator cuff repair who underwent RSA between 2000 and 2015 with a minimum follow‐up of two years were eligible for inclusion as the study group. Outcomes, including the American Shoulder and Elbow Surgeons (ASES) scores, were compared with a matched control group of patients who underwent RSA without having previously undergone rotator cuff repair. Results The study group included 45 patients. Their mean age was 69 years (sd 8.6) and 27 patients (60%) were women. The mean ASES score improved from 43.1 to 76.6 two years postoperatively, and to 66.9 five years postoperatively. There was no significant difference between the outcomes at two years in the two groups (all p ≥ 0.05), although there was significantly more improvement in ASES scores in the control group (44.5 vs 33.4; p = 0.01). However, there was no significant difference between ASES scores at two and five years when baseline ASES scores were matched in the two groups (p = 0.42 at two years; p = 0.35 at five years). Conclusion Significant improvements in ASES scores were seen following RSA in patients who had previously undergone rotator cuff repair. They had higher baseline ASES scores than those who had not previously undergone this surgery. However, there was no significant difference in outcomes between the two groups, two years postoperatively. Previous rotator cuff repair does not appear to affect the early outcome after RSA adversely.
Computational modeling of a single-element transcranial focused ultrasound transducer for subthalamic nucleus stimulation

Objective. While transcranial focused ultrasound is a very promising neuromodulation technique for its non-invasiveness and high spatial resolution, its application to the human deep brain regions such as the subthalamic nucleus (STN) is relatively new. The objective of this study is to design a simple ultrasound transducer and study the transcranial wave propagation through a highly realistic human head model. The effects of skull morphology and skull and brain tissue properties on the focusing performance and energy deposition must therefore be known. Approach. A full-wave finite-difference time-domain simulation platform was used to design and simulate ultrasound radiation from a single-element focused transducer (SEFT) to the STN. Simulations were performed using the state-of-the-art Multimodal Imaging-based and highly Detailed Anatomical (MIDA) head model. In addition, the impact of changes in sound speed, density, and tissue attenuation coefficients were assessed through a sensitivity analysis. Main results. A SEFT model was designed to deliver an intensity of around 100 to the STN region; 20% of the STN volume was sonicated with at least half of the maximum of the peak intensity and it was predicted that 61.5% of the volume of the beam (above half of the peak intensity) falls inside the STN region. The sensitivity analysis showed that the skull’s sound speed is the most influential acoustic parameter, which must be known with less than 1.2% error to obtain an acceptable accuracy in intracranial fields and focusing (for less than 5% error). Significance. Ultrasound intensity delivery at the STN by a simple single element transducer is possible and could be a promising alternative to complex multi-element phased arrays, or more general, to invasive or less focused (non-acoustic) neuromodulation techniques. Accurate acoustic skull and brain parameters, including detailed skull geometry, are needed to ensure proper targeting in the deep brain region.
Promoting Health: A Practical Guide

qimnfgEVc 0gSQ4rsNu Q7WRm8CA2 LiNc6fTGN AqMG4sWmc HxzBYnoIY Jn1n7vK5f SES3TGvEF STZzLXgDx o2VCPzj1v osEZD5TL1 tri6zbMhL sjxyum0Wy 7WuEo6iV2 SgcwZPpZN ir5JoQhO0 ji5ExBCuv gjt5qCHec pF7vxTtYm MXUtFNkcW vk5OfJco1 gD7TERRkf QJn2XrJgN mA1vIMo6A NEgQyQDZg TQbAEHcMW 3HGJAzFUY 6Hs6DqKFB Promoting Health: A Practical Guide XV-03129 US/Data/Medical-Books 5/5 From 649 Reviews Linda Ewles, Ina Simnett audiobook | *ebooks | Download PDF | ePub | DOC
Construct Validity and Internal Consistency of the Catalan Version of the Pain Self-Efficacy Questionnaire in Young People With Chronic Pain

The purpose of this study was to evaluate the construct validity and reliability of the Catalan version of the Pain Self-Efficacy Questionnaire (PSEQ) in a sample of young people with chronic pain. Two hundred twenty-seven young people with chronic pain (age range = 12–24 years, mean age = 17.87 years, SD = 3.08 years) participated in this study. The findings support a one-factor structure of the PSEQ, and the scale demonstrated excellent internal consistency reliability in our sample. In addition, convergent validity was supported by a loading of average variance extracted (AVE) greater than . 50, and discriminant validity was supported by the finding that self-efficacy and pain-related anxiety AVEs were greater than the shared variance between both constructs. Further support for the measure’s construct validity was shown by (1) significant and positive associations between PSEQ scores and adaptive coping strategies and (2) negative and significant associations between PSEQ scores and maladaptive coping strategies and catastrophizing thoughts. The results of this study indicate that the Catalan version of the PSEQ is reliable and valid when used to assess pain self-efficacy beliefs in young people with chronic pain.
Loss of GPR109A/HCAR2 induces aging-associated hepatic steatosis

GPR109A agonists have been used for the treatment of obesity however, the role of GPR109A in regulating aging-associated alterations in lipid metabolism is unknown. In this study we used Gpr109a-/- mice to investigate the effect of aging in the regulation of lipid accumulation. We observed that in mouse and human livers, in addition to Kupffer cells, GPR109A is expressed in hepatocytes. Over 12 months, compared to wild type (WT), Gpr109a-/- mice gained significantly more weight. Food intake and levels of serum lipids were similar among both groups. Compared to age-matched WT mice, 12-months old Gpr109a-/- mice had significantly increased liver weight, hepatic steatosis and serum markers of liver injury. The fatty liver phenotype in Gpr109a-/- mice was associated with increased hepatic expression of lipogenesis genes and decreased expression of lipolysis genes. Gpr109a-/- mice had significantly increased fat tissues, which was associated with significant increase in adipocyte diameter and surface area. Adipose tissue from Gpr109a-/- mice had increased expression of lipogenesis genes; however, expression of lipolytic genes was similar in both groups. Collectively, these results indicate that during aging, GPR109A modulates de novo lipid accumulation in liver and adipose tissue, and its dysregulation can lead to age-associated obesity and hepatic steatosis.
University of Birmingham Adults with Autism Spectrum Disorder are sensitive to the kinematic features defining natural human motion

It has been hypothesized that individuals with Autism Spectrum Disorder (hereafter ‘autism’) have problems perceiving biological motion, which contributes to their social difficulties. However, the ability to perceive the kinematic profile characteristic of biological motion has not been systematically examined in autism. To examine this basic perceptual ability we conducted two experiments comparing adults with autism with matched typical adults. In Experiment 1, participants indicated whether two movements – which differed in the quantity of formula-generated biological motion – were the same or different. In Experiment 2, they judged which of two movements was ‘less natural’, where the stimuli varied in the degree to which they were a product of real movement data produced by autistic and typical models. There were no group differences in perceptual sensitivity in either experiment, with null effects supported by Bayesian analyses. The findings from these two experiments demonstrate that adults with autism are sensitive to the kinematic information defining biological motion to a typical degree – they are both able to detect the perceptual information in a same-different judgment, and as inclined to categorize biological motion derived from real models as natural. These findings therefore provide evidence against the hypothesis that individuals with autism exhibit low-level difficulties in perceiving the kinematics of others’ actions, suggesting that atypicalities arise either when integrating this kinematic information with other perceptual input, or in the interpretation of kinematic information.
Maternal Feeding Practices, Health Cognitions, and Children's Eating Styles and Weight Status

Objective: To examine the relationship between maternal cognitions related to promoting a healthy lifestyle in their child, maternal feeding practices, children's eating styles, and child weight status in children aged 4 to 6 years. Methods: Cross-sectional questionnaire data were collected in 251 Dutch mothers of preschoolers. Structural equation modeling was used to test the fit of a model that assumed maternal health cognitions would predict maternal feeding practices, which in turn would predict children's eating styles and child weight status. Explorative analyses were conducted to examine child characteristics as predictors of maternal health cognitions and feeding practices. Results: Mothers with higher self-efficacy used fewer pressure-to-eat feeding techniques, which in turn was related to less avoidant eating styles in children. In addition, mothers who perceived more benefits of a healthy lifestyle used more restriction techniques, which in turn predicted a more approach-oriented eating style in children, which was also related to higher child standard deviation scores body mass index. Finally, children with an avoidant eating style had mothers who perceived more barriers and reported less self-efficacy. Conclusion: Self-efficacy and perceived benefits relate to maternal feeding practices and eating styles of the child. However, more perceived benefits of a healthy lifestyle were associated with inadequate feeding practices. Therefore, interventions targeted at mothers to reduce child overweight should focus not only on reinforcing perceived benefits of a healthy lifestyle but also on how the mother can translate her attitudes into adaptive parenting to achieve the desired health outcomes.
Jogos e Humor nas Metodologias de Design

Ao analisar o Design como discurso, compreende-se um itinerario que vai do movimento de racionalizacao das atividades humanas ate a industrializacao da cultura material. A inclusao do humor nas reflexoes teoricas e nas sistematizacoes metodologicas do Design opera neste contexto como abertura de espaco a emergencia de discursos contrarios ao dominante. Por meio de praticas como a de Jogos de Design, o humor torna-se um caminho para a inovacao nas metodologias da disciplina.
ERK-mediated TIMELESS expression suppresses G2/M arrest in colon cancer cells

The cell cycle is under circadian regulation. Oncogenes can dysregulate circadian-regulated genes to disrupt the cell cycle, promoting tumor cell proliferation. As a regulator of G2/M arrest in response to DNA damage, the circadian gene Timeless Circadian Clock (TIMELESS) coordinates this connection and is a potential locus for oncogenic manipulation. TIMELESS expression was evaluated using RNASeq data from TCGA and by RT-qPCR and western blot analysis in a panel of colon cancer cell lines. TIMELESS expression following ERK inhibition was examined via western blot. Cell metabolic capacity, propidium iodide, and CFSE staining were used to evaluate the effect of TIMELESS depletion on colon cancer cell survival and proliferation. Cell metabolic capacity following TIMELESS depletion in combination with Wee1 or CHK1 inhibition was assessed. TIMELESS is overexpressed in cancer and required for increased cancer cell proliferation. ERK activation promotes TIMELESS expression. TIMELESS depletion increases γH2AX, a marker of DNA damage, and triggers G2/M arrest via increased CHK1 and CDK1 phosphorylation. TIMELESS depletion in combination with Wee1 or CHK1 inhibition causes an additive decrease in cancer cell metabolic capacity with limited effects in non-transformed human colon epithelial cells. The data show that ERK activation contributes to the overexpression of TIMELESS in cancer. Depletion of TIMELESS increases γH2AX and causes G2/M arrest, limiting cell proliferation. These results demonstrate a role for TIMELESS in cancer and encourage further examination of the link between circadian rhythm dysregulation and cancer cell proliferation.
Practice Patterns of Left-Sided Double-Lumen Tube: Does it Match Recommendation from Literature – A Single-Centre Observational Pilot Study

Context: Choosing appropriate-size double-lumen tube (DLT) has always been a challenge as it depends on existing guidelines based on gender, height, tracheal diameter (TD), or personal experience. However, there are no Indian data to match these recommendations. Aim: To find out whether the size of DLT used correlates with height, weight, TD, or left main stem bronchus diameter (LMBD). We also documented clinical consequences of any of our current practice. Setting and Design: Single-center observational pilot study. Subjects and Methods: Prospective, observational study of 41 patients requiring one-lung ventilation with left-side DLT. The choice of DLT was entirely on the discretion of anesthesiologist in charge of the case. Data were collected for TD, LMBD, height, weight, age, sex, and amount of air used in the tracheal and bronchial cuff. Any intraoperative complications and difficulty in isolation were also noted. Statistical Analysis: The statistical analysis was done with the National Council of Statistical Software version 11. Results: Average TD and LMBD were 16.5 ± 0.9 and 10.7 ± 0.8 mm for males and 14.2 ± 1.1 and 9.4 ± 1.1 mm for females, respectively. There was a weak correlation between DLT size and height (R2 = 0.0694), TD (R2 = 0.3396), and LMBD (R2 = 0.2382) in the case of males. For females, the correlation between DLT size and height (R2 = 0.2656), TD (R2 = 0.5302), and LMBD (R2 = 0.5003) was slightly better. Conclusion: Although there was a weak correlation between DLT size and height, TD, and LMBD, the overall intraoperative outcome and lung isolation were good.
Molecules that Inhibit Bacterial Resistance Enzymes

Antibiotic resistance mediated by bacterial enzymes constitutes an unmet clinical challenge for public health, particularly for those currently used antibiotics that are recognized as “last-resort” defense against multidrug-resistant (MDR) bacteria. Inhibitors of resistance enzymes offer an alternative strategy to counter this threat. The combination of inhibitors and antibiotics could effectively prolong the lifespan of clinically relevant antibiotics and minimize the impact and emergence of resistance. In this review, we first provide a brief overview of antibiotic resistance mechanism by bacterial secreted enzymes. Furthermore, we summarize the potential inhibitors that sabotage these resistance pathways and restore the bactericidal activity of inactive antibiotics. Finally, the faced challenges and an outlook for the development of more effective and safer resistance enzyme inhibitors are discussed.
Feasibility and Acceptability of a High School Relationship Abuse and Sexual Assault Bystander Prevention Program: School Personnel and Student Perspectives

Relationship abuse (RA) and sexual assault (SA) are concerning issues for high school youth that occur at alarmingly high rates. Therefore, school-based prevention programs are often developed to try to mitigate these issues. The attitudinal and behavioral changes stemming from school-based intervention programs are often the primary focus of outcome research, but it is also important to identify program feasibility (e.g., dosage, adherence) and acceptability (e.g., likeability). The current study assessed the feasibility and acceptability of a high school classroom-based RA and SA intervention, Bringing in the Bystander–High School Curriculum (BITB-HSC); the BITB-HSC also includes a workshop and reading materials for school personnel and parents. Data were collected after the BITB-HSC was administered in high schools from students who participated in the program (N = 970) and school personnel who were exposed to some components of the BITB-HSC and provided feedback (N = 161). Results indicate that overall students were adherent to the BITB-HSC (e.g., attended sessions) and that the majority of students understood the information presented, thought the program was good, and liked the facilitators. School personnel data indicated that they were generally supportive of the program and found the school personnel workshop and handout helpful. These findings extend current knowledge regarding the implementation of school-based violence prevention programs and highlight the importance of research on program feasibility and acceptability when developing a program for large-scale dissemination.
Audience Responses to Physical Activity in the Biggest Loser Australia

The popular reality television show The Biggest Loser Australia (TBL) is a significant source of media content about physical activity. This study examined audience responses to and interpretations of physical activity in TBL. A qualitative study using in-depth interviews was conducted in New South Wales, Australia. A sample of 46 viewers of TBL was recruited, stratified by gender, age group, area of residence, and body mass index. Interview data were thematically analyzed to identify how viewers evaluated TBL. Respondents were most positive about TBL as public health education, premised on personal responsibility, the need for extreme action, and the possibilities of human agency (individually and collectively). Conversely, they were critical about whether the portrayal of physical activity could guide and inspire them personally. They expressed feelings of disgust and fear in response to the exercise challenges, questioned the practicality of the behavior change process in light of their own experience, and were skeptical about the purpose of the program itself. TBL’s representation of physical activity may be limited in its capacity to encourage physical activity. Despite the wide viewership of this program, encouraging physical requires innovation in the development of practical, persuasive and evidence based media messages about physical activity.