Miracle-dz/UniFAR-FTUs huggingface dataset:
Research on the Influence of Migrant Children:Between Educational Settings and Social Integration

In order to research the social integration of migrant children,we do this work from the perspective of education policy,especially the policy of education settings.Through multiple regression and path analysis,it is found that the social integration of migrant children is obviously different in different education settings,and education equity is an intervening variable.So,it is necessary for us to take some measures to improve the migrant children social integration from social policy,family,school and children themselves.
Replication of Hepatitis C Virus Subgenomes in Nonhepatic Epithelial and Mouse Hepatoma Cells

ABSTRACT The hepatitis C virus (HCV) pandemic affects the health of more than 170 million people and is the major indication for orthotopic liver transplantations. Although the human liver is the primary site for HCV replication, it is not known whether extrahepatic tissues are also infected by the virus and whether nonprimate cells are permissive for RNA replication. Because HCV exists as a quasispecies, it is conceivable that a viral population may include variants that can replicate in different cell types and in other species. We have tested this hypothesis and found that subgenomic HCV RNAs can replicate in mouse hepatoma and nonhepatic human epithelial cells. Replicons isolated from these cell lines carry new mutations that could be involved in the control of tropism of the virus. Our results demonstrated that translation and RNA-directed RNA replication of HCV do not depend on hepatocyte or primate-specific factors. Moreover, our results could open the path for the development of animal models for HCV infection.
Pricing of contingent convertibles under smile conform models

We look at the problem of pricing CoCo bonds where the underlying risky asset dynamics are given by a smile conform model, more precisely an exponential Levy process incorporating jumps and heavy tails. A core mathematical quantity that is needed in closed form in order to produce an exact analytical expression for the price of a CoCo is the law of the infimum of the underlying equity price process at a fixed time. With the exception of Brownian motion with drift, no such closed analytical form is available within the class of Levy process that are suitable for financial modeling. Very recently however there has been some remarkable progress made with the theory of a large family of Levy processes, known as β-processes, cf. Kuznetsov [12] and Kuznetsov et al. [14]. Indeed for this class of Levy processes, the law of the infimum at an independent and exponentially distributed random time can be written down in terms of the roots and poles of its characteristic exponent; all of which are easily found within regularly spaced intervals along one of the axes of the complex plane. Combining these results together with a recently suggested Monte-Carlo technique, due to Kuznetsov et al. [13], which capitalises on the randomised law of the infimum we show the efficient and effective numerical pricing of CoCos. We perform our analysis using a special class of β-processes, known as β-VG, which have similar characteristics to the classical Variance-Gamma model. The theory is put to work by performing two case studies. After calibrating our model to market data, we price and analyze one of the Lloyds CoCos as well as the first Rabo CoCo.
Preliminary investigations into a novel, long‐acting, injectable, intramuscular formulation of omeprazole in the horse

BACKGROUND Pilot investigations have suggested that a novel, long-acting, injectable i.m. formulation of omeprazole (LA-OMEP) can induce acid suppression for up to 7 days following a single injection. OBJECTIVES To investigate the pharmacodynamics and assess the clinical efficacy of the LA-OMEP formulation. STUDY DESIGN Part A comprised a pharmacodynamic study. Part B consisted of a pilot clinical trial. METHODS Part A enrolled six adult Thoroughbred horses with percutaneous gastrotomy tubes. Intragastric pH was measured for continuous 23-h periods (08.00-07.00 h) for eight consecutive days (days 0-7). A single 2.0-g dose of a 100 mg/mL LA-OMEP formulation was administered at 08.00 h on day 1. In Part B, 26 horses with squamous or glandular gastric disease were enrolled based on routine gastroscopic evaluation. Once enrolled, horses received 2.0 g of the 100 mg/mL LA-OMEP formulation by i.m. injection on days 0 and 7. Repeat gastroscopy was performed on days 14 (23 horses) or 16 (one horse). RESULTS In Part A, the percentage of time during which pH was above 4 exceeded 66% for days 1-4 in all horses and days 1-7 in four of the six horses studied. In Part B, healing was observed in all 22 (100%, 95% confidence interval [CI] 89-100%) horses with squamous disease and in nine of 12 (75%, 95% CI 47-92%) horses with glandular disease. Improvement, by at least one grade, was observed in all 22 (100%, 95% CI 89-100%) horses with squamous disease and in all 12 (100%, 95% CI 81-100%) horses with glandular disease. No worsening of lesions was observed. Lesion grade decreased over time in both the squamous (P<0.0001) and glandular (P = 0.0024) mucosa. MAIN LIMITATIONS Small sample sizes. CONCLUSIONS The results of the present study compare favourably with previous reports on the pharmacodynamics of omeprazole and the clinical outcomes of trials reporting response to oral omeprazole therapy.
On The Teaching Study of Health Education Curriculum of Physical Education Majors

Through using the method of questionnaire investigation,this paper makes a research of the health education curriculum and its teaching of the P.E majors.The result shows that students had many misconceptions on health so that behaviors harmful to health such as smoking,and drinking are frequently seen and getting worse.The practical study on teaching content and mode for health education result in good effects that form corresponding suggestions for future teaching.
Backward masking task performance in stable, euthymic out-patients with bipolar disorder

Background. Several studies have suggested that visual backward masking (VBM) impairment is present in patients with bipolar disorder, but the clinical features, such as current symptoms, treatment status and past burden of illness that may contribute to the impairment have not been well described. This study examined well-characterized euthymic patients on two VBM tasks to ascertain the extent of VBM impairment in this group and the clinical correlates of this impairment. Method. Twenty-eight euthymic patients with a DSM-IV diagnosis of bipolar disorder were matched by age, sex and IQ with 28 non-psychiatric control subjects. Both groups completed two VBM tasks; one required subjects to locate the target stimulus, one required identification of the target stimulus. Reaction times and error rates across a range of target-mask inter-stimulus intervals were assessed. Results. Patients were significantly slower and had more errors on both VBM tasks. There was a significant relation between reaction times on the identification task and past burden of illness, particularly past number of depressions. There was no discernible impact of treatment status on reaction time or performance, including no difference in lithium-treated versus not treated subjects. Conclusions. These results are consistent with previous reports of neuropsychological deficits in euthymic bipolar disorder patients. The potential benefit to employing tasks such as VBM is that it may provide a method for relating clinical variables such as illness burden with known neural pathways in order to elucidate better the pathophysiology leading to impaired cognitive performance in patients with bipolar disorder.
Hematologic and Bone Marrow Changes in Children with Protein-Energy Malnutrition

Background: All systems in an organism are affected by protein-energy malnutrition (PEM), but one of the worst affected is the hematopoietic system. Today PEM remains a very serious problem in developing countries. We examined the relationships between clinical features, hematological, and bone marrow changes with severe PEM from Turkey. Method: We evaluated 34 (11 females and 23 males) consecutive cases of severe PEM, with no underlying diseases aged 3–20 months. The clinical nutritional conditions of the patients were determined using the Wellcome-Trust PEM classification. Ten of the patients were in the Marasmic-Kwashiorkor (M-K) group, 10 were in the Kwashiorkor (KW) group, and 14 were in the Marasmic (M) group. Full blood count, protein, albumin, serum iron (SI), iron-binding capacity (TIBC), ferritin, vitamin B12, folic acid, complement-3 (C3), complement-4 (C4), and bone marrow were investigated in all groups. Results: Anemia was detected in 97% of patients. We determined serum iron levels were low in 67.6% of the patients, TS levels were low in 76.4% of the patients and ferritin levels were low in 20.5%. The level of vitamin B12 was normal in all patients. Bone marrow analysis showed erythroid series hypoplasia in 28.5% of patients in the M group, 50% in the KW group, and 30% in the M-K group. Marrow iron was absent in 58.8% of patients. Conclusion: The most common hematologic change in the children with PEM was anemia and major cause of anemia was iron deficiency in this study. Patients with severe PEM have normal Vit B12 and serum folate levels. Most of the patients with severe PEM had normal cellularity with megaloblastic and dysplastic changes in bone marrow due to the inadequate and imbalanced intake of protein and energy.
Accounting for the spouse when measuring inequality of opportunity

The existing literature on inequality of opportunity (IOp) has not addressed the question of how the circumstances and choices of spouses in a couple should be treated. By omitting information relevant to the spouse in IOp estimations, the implicit assumption has been full responsibility for the spouse’s income, effort and circumstance variables. In this paper, we discuss whether or not the spouse’s characteristics should be treated as responsibility factors. Using German micro data, we analyze empirically, how IOp estimates are affected when a spouse’s circumstance or effort variables are included in the analysis. We find that including spousal variables can increase IOp measures by more than 20 (35) percent for gross (net) earnings. The less responsibility assumed for the partner’s variables, the higher the IOp estimate.
Safety of liposomal amphotericin B (AmBisome) in 187 transplant recipients treated with cyclosporin.

The safety of AmBisome was evaluated in 187 transplant recipients treated for 197 episodes. Patients included 89 bone marrow transplant recipients, 64 liver transplant recipients, 20 renal transplant recipients and 14 recipients of combined organs. AmBisome was instituted for verified invasive fungal infection in 34 cases, suspected invasive fungal infections in 80 cases and as prophylaxis in 83 cases. AmBisome was given for a median of 11 days (range 1-112 days) with a maximum daily dose of 1.49 +/- 0.70 mg/kg/day (mean +/- SD). The total cumulative dose of AmBisome was 1.11 +/- 1.78 g (mean +/- SD). Side-effects definitely attributed to AmBisome therapy included low potassium (n = 3), low back pain (n = 3), dyspnoea (n = 2), allergic rash (n = 1), nausea and vomiting (n = 1), confusion (n = 1), rise in alkaline phosphatase (n = 1) and cholecystitis (n = 1) with an overall incidence of 13 of 197 (7%). AmBisome was discontinued due to side-effects in 6 (3%) of the cases. During AmBisome treatment the mean cyclosporin dose was 9.6 +/- 28.8 mg/kg/day. Compared to pre- and post-AmBisome therapy there was a significantly increased cyclosporin concentration in blood during AmBisome therapy. Side-effects with possible association to AmBisome therapy included low serum potassium (36%), increase in serum creatinine (31%), rise in alkaline phosphatases (26%) and fever (3%). The overall mean increase in serum creatinine was 20%. Other possible side-effects like headache, abdominal pain, rash, rise in bilirubin, cramps and pancreatitis was seen in single patients. (ABSTRACT TRUNCATED AT 250 WORDS)
Older Adults' Training Preferences for Learning to Use Technology

Older adults may benefit from using technology in their everyday lives. However, adults over 65 may need more training than their younger counterparts given they have had less experience with technology. In this study, 113 adults between the ages of 65 and 85 participated in focus group interviews discussing their training needs and preferences for technology items used in the home. Participants expressed an interest in receiving additional training, particularly for specific tasks. Participants also discussed preferences for various characteristics of training, such as who should conduct the training and for their preferred method of training. One of the most frequently discussed preferences was for self-training using text materials, such as a manual.
Increased prevalence of the alpha‐1‐antitrypsin (A1AT) deficiency‐related S gene in patients infected with human immunodeficiency virus type 1

Large variation exists in susceptibility to infection with Human Immunodeficiency Virus Type 1 (HIV), and disease progression. These observations demonstrate a role for antiretroviral host factors. Several reports describe α1‐antitrypsin (A1AT), the most abundant circulating serine protease inhibitor, as a potent suppressor of HIV infection and replication. We identified the normal (M) and most common deficiency‐associated (S and Z) isoforms of the A1AT gene in patients infected with HIV from four multicenter cohorts. The level of disease progression in the patients was characterized and the patients were grouped into as elite controllers (EC), long‐term non‐progressors (LTNP), or progressors (Prog). No significant difference in the distribution of A1AT alleles was observed in the EC, LTNP, or Prog groups. However, significantly increased prevalence of the A1AT deficiency‐associated S allele was observed in HIV‐infected patients compared to the prevalence of S A1AT in the general population. These results suggest that deficiency in A1AT may be a risk factor for acquisition of HIV infection, but physiological A1AT concentrations do not affect disease progression after infection occurs. J. Med. Virol. 86:23–29, 2014. © 2013 Wiley Periodicals, Inc.
Characteristics of okadaic acid—induced cytotoxic effects in CHO K1 cells

This article reports the results of investigations into the process of cell death induced in the Chinese hamster ovary cell K1 subclone (CHO K1) by okadaic acid (OA), a hydrophobic polyether produced by marine dinoflagellates. The IC50 was about 13 nM OA after 24 h of treatment, as determined using neutral red. With the MTT assay, the IC50 was 25 nM, although in this case 25% of the initial staining was still observed at 100 nM. Hoechst staining showed that mitotic figures accumulated at 12 nM OA after a 24‐ or 48‐h treatment. In experiments limited to a 3‐day treatment without changing the medium, CHO K1 cells were engaged in the death process at 50 nM OA after about 20 h and at 10 nM OA after 48 h. In many cells nuclear fragmentation that resulted in the apparent appearance of vesicles correlated with increasing cellular volume. But additional cell fragmentation was not observed with any treatment, and the chromatin material seemed to progressively disappear inside the cells. DNA fragmentation was analyzed by electrophoresis and with the TUNEL technique. With both techniques, the DNA was fragmented by 48 h in both 25 and 50 nM OA. Electrophoresis showed that both adherent and nonadherent cells were affected. Annexin‐positive/ propidium iodide (PI)–negative cells were rarely observed after OA treatment. Some were seen under the scanning cytometer after 20 h at 50 nM OA or after 48 h at 10 nM OA, but they were never detected by flow cytometry. Most of the time scanning cytometry showed either unstained cells or PI‐positive (annexin‐positive or ‐negative) cells (48 h, 50 nM, or 72 h, 10 nM). Flow cytometry cytograms showed two cell subpopulations: one composed of a majority of smaller cells, the other of larger cells. The larger cells markedly decreased with time and OA treatment (50 and 100 nM). Stained‐cell counting showed that all cells that stained were both annexin‐ and PI positive and that most PI‐positive cells were smaller. Ki67 antigen labeling showed the proliferative activity of CHO K1 cultures but also demonstrated the loss of this activity in smaller cells treated with 50 nM OA for 48 h. We concluded that in our culture conditions the main OA target within CHO K1 cultures was dividing cells. Our results suggest that cells with disturbed metaphase–anaphase enter apoptosis, leading to necrotic daughter cells. © 2003 Wiley Periodicals, Inc. Environ Toxicol 18: 383–394, 2003
Gender, Race, and Age

While stereotypes about gender, race, and age (particularly old age) have been studied independently, few have examined the content of compound stereotypes that consider the intersection of gender, race, and age. Using a within-subjects design, we examined stereotypes as a function of target gender (male, female), race (Black, White), and age across the life span (adolescent, young adult, middle-aged, young-old, and old-old). Participants rated 20 target groups on 10 attributes representative of either an agentic (e.g., ambitious) or communal (e.g., considerate) orientation. Participants were presented only with categorical information (e.g., Black, 85-year-old, males), and ordering of categorical information and target groups was counterbalanced across participants. We hypothesized differential effects of target gender and race as a function of age. Multivariate analyses of variance on each attribute revealed significant main effects that supported traditional stereotype research, but significant interactions revealed a more complicated picture. Overall, results showed that while gender stereotypes about agency and communion generally hold up across the life span, they are more applicable to White than Black targets. Results also supported the notion that we hold unique stereotypes based on multiple social categories rather than simply perceiving one social category as more salient than another, which was best exemplified in the case of Black female targets that were less likely to be perceived in gender stereotypic ways across the life span. We suggest stereotype research needs to shift to accommodate for the complexity and diversity of real people.
Kernel spectral regression of perceived age from hybrid facial features

This paper introduces an advanced age-determination technique using hybrid facial features and Kernel Spectral Regression, a nonlinear dimensionality reduction method. In the preprocessing stage, the logarithmic nonsubsampled contourlet transform (NSCT) is conducted to denoise and amplify facial wrinkles that help to distinguish young faces from elder ones. Then the hybrid facial features that combine both local and holistic features are extracted from the preprocessed images. Our novel Uniform Local Ternary Patterns (ULTP) are used as the local features. Meanwhile the holistic features are extracted by using the Active Appearance Model (AAM) to encode each face. Kernel Spectral Regression is used to minimize inter-class distances while maximizing intra-class distances of feature sets. These reduced features are used to classify faces into two age groups (age-classification). An age-determination function is then constructed for each age group in accordance with physiological growth periods for humans — pre-adult (youth) and adult. Compared to published results, this method yields promising results in overall mean absolute error (MAE), mean absolute error per decade of life (MAE/D), and cumulative match score in various face aging corpuses.
Social Workers and Delivery of Evidence-Based Psychosocial Treatments for Substance Use Disorders

Social workers encounter individuals with substance use disorders (SUDs) in a variety of settings. With changes in health care policy and a movement toward integration of health and behavioral health services, social workers will play an increased role vis-á-vis SUD. As direct service providers, administrators, care managers, and policy makers, they will select, deliver, or advocate for delivery of evidence-based SUD treatment practices. This article provides an overview of effective psychosocial SUD treatment approaches. In addition to describing the treatments, the article discusses empirical support, populations for whom the treatments are known to be efficacious, and implementation issues.
Expression of Endo180 is spatially and temporally regulated during wound healing

Aims: Interactions of cells with the extracellular matrix are important for normal wound healing and may play a role in scar formation. Remarkably, wound healing in human gingiva does not result in scar formation and serves as a model for wound regeneration. Endo180 (CD280) is a cell surface receptor that has novel functions to regulate cell migration and bind and internalize collagens that are key processes in wound healing. The aim of this study was to examine the expression of Endo180 during gingival wound regeneration.
Measuring What Matters: Industry Specificity Helps Companies and Investors Gain Traction on Sustainability

Financial analysts interpret the performance of companies and their securities through an industry lens. Just as an industry approach is critical in financial analysis, it's also critical in helping investors evaluate sustainability performance, since sustainability issues differ from one industry to the next—in large because of differences in how companies use natural and other social resources when bringing their goods and services to market, and how they impact society and the environment in the process.The Sustainability Accounting Standards Board (SASB) was created in 2012 to deliver a full set of sustainability accounting standards that can be used to guide industry‐specific corporate sustainability disclosure to the capital markets. SASB has now issued provisional standards for 79 industries, thereby enabling companies and investors for the first time to identify patterns of sustainability risks and opportunities both across and within industries. Although high‐level issues such as climate change, product safety, and resource intensity and scarcity have material impacts across a variety of sectors, those impacts often vary greatly from one industry to the next. Thus, although the risk may be ubiquitous, it is also differentiated to the point that each industry has its own distinct sustainability profile. Understanding these unique profiles can help companies better manage the issues that are most likely to present material risks to their industries.
Freeze-dried and spray-dried zinc-containing silica microparticles entrapping insulin

New approaches for oral administration of insulin are strongly related to novel insulin carriers. The aim of this study was the insulin microencapsulation in a new zinc-silica matrix for drug protection and controlled release. Zinc-silica microparticles loaded with insulin were obtained by sol-gel process via spray drying and freeze drying methods. Inorganic silica matrix isolates and constrains the movement of the biomolecules preventing their aggregation and denaturation, while the zinc oxide improves the system stability. Moreover, formation of insulin hexamers in the presence of zinc ions leads to an increased stability of the insulin three-dimensional structure during preparation, storage and release. The particles were characterized with respect to average size, specific surface area, porosity and morphology. In vitro behavior of insulin-loaded particles together with protein structural conformation was also evaluated. The release profile can be adapted by synthesis route of microparticles.