Miracle-dz/UniFAR-FTUs huggingface dataset:
Lysinibacillus cresolivorans sp. nov., an m-cresol-degrading bacterium isolated from coking wastewater treatment aerobic sludge.

A Gram-stain-positive, rod-shaped, facultatively anaerobic, endospore-forming bacterium (designated strain SC03T) was isolated from the aerobic treatment sludge of a coking plant (Shaoguan City, China). The optimal pH and temperature for growth were pH 7.0 and 35 °C. On the basis of 16S rRNA gene sequence analysis, strain SC03T was related to the genus Lysinibacillus and the similarity between strain SC03T and the most closely related type strain, Lysinibacillus macroides LMG 18474T, was 94.4 %. The genomic G+C content of the DNA of strain SC03T was 41.2 mol%. Chemotaxonomic data supported the affiliation of strain SC03T to the genus Lysinibacillus. These properties include MK-7 as the predominant menaquinone; iso-C15 : 0 and iso-C16 : 0 as major fatty acids; A4α (l-Lys-d-Asp) as the cell-wall peptidoglycan type; and diphosphatidylglycerol, phosphatidylglycerol, phosphatidylethanolamine plus three unknown phospholipids as polar lipids. The phenotypic, phylogenetic and chemotaxonomic characters enable the differentiation of strain SC03T from recognized Lysinibacillus species. Thus, strain SC03T represents a novel species of the genus Lysinibacillus, for which the name Lysinibacillus cresolivorans sp. nov. is proposed. The type strain is SC03T ( = NRRL B-59352T = CCTCC M 208210T).
Cross-Sectional Study on Occupational Noise and Hypertension in the Workplace

To determine whether noise conditions at the workplace are associated with hypertension in Japanese male blue-collar workers, the authors analyzed data obtained in an annual workplace health examination. Two hundred forty-two workers who used ear protectors at their jobs in a paper manufacturing plant served as a noisy workplace group, and 173 individuals who worked in a chemical plant comprised a nonnoisy workplace group. The prevalence of hypertension was 16.9% in the noisy workplace group and 34.7% in the nonnoisy workplace group (p <.01). A Mantel-Haenzel analysis showed the difference between the 2 groups to be significant. A logistic regression analysis with adjustment for confounding factors also showed a significant inverse association between hypertension and noise conditions at the workplace (odds ratio = 0.48; 95% confidence interval = 0.28-0.81). The implementation of guidelines for occupational noise management might have contributed to the workers' concern over the prevention of adverse health effects caused by workplace noise.
Coeliac Disease among Healthy Members of Multiple Case Coeliac Disease Families

Background: The main objective of the study was to assess the frequency of undetected coeliac disease among the first-degree relatives of families with two or more previously diagnosed coeliac disease patients. The value of the serum endomysial antibody test as a single means of detecting clinically silent coeliac disease was evaluated. The correlation of endomysial and tissue transglutaminase antibodies and the correlation of endomysial antibodies to the HLA typical for coeliac disease was determined. Methods: A total of 137 multiple-case coeliac disease families with 872 family members were recruited; 466 healthy family members were simultaneously screened for gliadin and endomysial antibodies and thereafter for tissue tranglutaminase antibodies. Antibody-positive persons were typed for HLA-DQ2 and DQ8. The diagnosis of coeliac disease was based on the typical mucosal lesion on small-bowel biopsies. Results: Forty-four (9.4%) of the healthy family members were positive for endomysial and 48 (10.3%) for gliadin antibodies; 42 biopsies revealed 29 new coeliac disease patients (6.2% of healthy individuals). Endomysial antibodies detected 97% and gliadin antibodies 52% of the new cases. All 44 endomysial-antibody-positive and 35 of 48 gliadin-antibody-positive individuals were positive for DQ2. Tissue transglutaminase antibodies corresponded well with endomysial antibodies. Conclusions: Undetected coeliac disease is common even among healthy first-degree relatives of multiple case families. The findings emphasize the value of serum endomysial antibodies in the detection of clinically silent coeliac disease. Endomysial-antibody-positive individuals, unlike gliadin-antibody-positive ones, share the coeliac disease-type HLA-DQ.
Liver and muscle fatty acid composition of mature and immature rainbow trout (Oncorhynchus mykiss) fed two different diets

Fatty acid composition of liver and muscle tissues of immature and mature Oncorhynchus mykiss fed on two different diets were determined. Fatty acid analyses were carried out by gas chromatography. Palmitic acid (C16:0), oleic acid (C18:1 n-9), linoleic acid (C18:2 n-6) and docosahexaenoic acid (C22:6 n-3) were the major components in both liver and muscle tissues of immature and mature rainbow trout of both sexes. The amounts of C22:6 n-3 were higher in the liver (29.04 ± 0.06 − 27.41 ± 0.17%) and muscle (13.05 ± 0.40 − 11.37 ± 0.21%) of immature fish than in mature fish and depended on the composition of the diet. Results of this study show that fatty acid composition in fish tissues can considerably vary, depending on the age of fish and their diet. Thus more detailed studies are necessary on the influence of diet on immature and mature fish fatty acid composition. The age and diet of fish consumed may also be important for human health.
Effect on mutagenicity of the stepwise removal of hydroxyl group and chlorine atoms from 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone: 13C NMR chemical shifts as determinants of mutagenicity.

The response of mutagenicity to the stepwise replacement of chlorine atoms and the hydroxyl group by hydrogen in 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX, 1) was determined in several assays by using Salmonella typhimurium tester strain (TA100). In all, eight MX derivatives were assayed. Several were studied together in at least one assay. In addition to MX, the seven included 3-chloro-4-(dichloromethyl)-2(5H)-furanone (RMX, 2), 3-chloro-4-(chloromethyl)-5-hydroxy-2(5H)-furanone (3), 3-chloro-4-(chloromethyl)-2(5H)-furanone (4), 4-(chloromethyl)-5-hydroxy-2(5H)-furanone (5), 4-chloromethyl-2(5H)-furanone (6), and 4-(dichloromethyl)-2(5H)-furanone (8). Compounds 1-6 were mutagenic. Compound 8 gave erratic results. 4-(Acetoxymethyl)-2(5H)-furanone (11) was nonmutagenic. The largest drop in mutagenicity amounted to a factor of about 10(2) for the replacement of the hydroxyl group or a C-3 chlorine atom from 3. Other replacements of the hydroxyl group or a C-3 or C-6 chlorine atom amounted to mutagenicity diminished by a factor of only 10. On the basis of the rates of UV spectral changes under assay conditions, chemical half-life values (ct 1/2) for 1-6 and 8 were estimated as indicators of compound stability. However, mutagenicity differences were shown to result principally from the intrinsic mutagenicities of the six compounds 1-6 rather than from differences in stability. (ABSTRACT TRUNCATED AT 250 WORDS)
Characteristics of assistive technology service delivery models: stakeholder perspectives and preferences

Purpose. The purpose of this study was to identify the key characteristics of an assistive technology service delivery model preferred by the various stakeholders in Manitoba, Canada. Methods. A descriptive, exploratory approach consistent with qualitative research design was used to explore this issue. Three focus groups were held using a semi-structured interview guide and a hypothetical case study to guide the discussion. Eighteen adults participated in the study, each representing one of three groups of stakeholders (assistive technology service providers, funders and users). Interviews were audiotaped, transcribed and analysed using an inductive process to develop categories and themes. Results. Three primary themes emerged from the data: the user of assistive technology is a unique individual; a decision-making process exists; and, assistive technology devices and services are complex. Based on the study results, recommendations for the delivery of assistive technology services are outlined. Conclusions. The results of this study may be useful for developing funding guidelines, supporting the importance of assistive technology in enabling meaningful activities, and examining current delivery of services in different contexts.
Prevalence of gingival overgrowth induced by calcium channel blockers: a community-based study.

BACKGROUND The prevalence of gingival overgrowth induced by chronic medication with calcium channel blockers is uncertain. Although there have been several studies examining this question, the results are conflicting, with previous estimates ranging from 20% to 83%. There have been only 2 studies examining the prevalence of overgrowth induced by diltiazem and amlodipine, with estimates of 74% and 3.3%, respectively. METHODS The current study aimed to address the problems associated with these studies by examining a sample of patients taking one of 3 calcium channel blockers, who were drawn from a community-based population in northeastern England. Nine hundred eleven (911) subjects were recruited from general medical practices in the area. Of these, 442 were taking nifedipine, 181 amlodipine, and 186 diltiazem. In addition, 102 control subjects were examined. Drug and demographic data for each subject were recorded. The periodontal condition of all subjects was assessed including plaque index, papillary bleeding index, and a photograph of the anterior gingivae for subsequent analysis of overgrowth severity. RESULTS More than six percent (6.3%) of subjects taking nifedipine were seen to have significant overgrowth. This overgrowth was statistically greater than the amount of overgrowth seen in either of the other 2 drug groups or the control population. The prevalence of gingival overgrowth induced by amlodipine or diltiazem was not statistically significant when compared to the control group. The severity of overgrowth within the nifedipine group was found to be related to the amount of gingival inflammation and also to the gender of the subject, with males being 3 times as likely to develop overgrowth than females. CONCLUSIONS The prevalence of clinically significant overgrowth related to chronic medication with calcium channel blockers is low, i.e., 6.3% for nifedipine. Males are 3 times as likely as females to develop clinically significant overgrowth. The presence of gingival inflammation is an important cofactor for the expression of this effect.
CDH13 gene coding t‐cadherin influences variations in plasma adiponectin levels in the Japanese population

Adiponectin is most abundantly expressed in adipose tissue and well known to play an important role in metabolic regulation. Several studies have attempted to identify the genetic determinants of metabolic syndrome (MetS), though no study has revealed a cis‐ or trans‐single nucleotide polymorphism (SNP) that affects plasma adiponectin levels, except the adiponectin structure gene and genes encoding adiponectin‐regulatory proteins. We performed a genome‐wide association study in regards to plasma adiponectin concentrations in 3,310 Japanese subjects. We identified the strongest statistically associated SNP (rs4783244) with adiponectin levels (P = 3.8 × 10−19) in the first intron of CDH13 (T‐cadherin) gene in a 30‐kb haplotype block covering the promoter region to first intron. In addition, rs12051272 SNP genotypes in linkage disequilibrium with rs4783244 were found to be more significantly associated with adiponectin levels (P = 9.5×10−20) and specifically with the levels of high‐molecular weight (HMW) adiponectin, a subtype form associated with parameters related to glucose metabolism. Our results did show more significant association with adiponectin levels than rs12444338 (in CDH13) SNP genotypes reported recently. We suggest that the phenotype‐affecting haplotype tagged by rs12051272 SNP would affect the plasma adiponectin levels and that we have to take the CDH13 genotype into account before considering the functional relevance of the adiponectin level. Hum Mutat 33:402–410, 2012. © 2011 Wiley Periodicals, Inc.
Patient Perceptions concerning Pain Management in the Treatment of Rheumatoid Arthritis

Previous qualitative studies have revealed discrepancies between patients' and physicians' perceptions of rheumatoid arthritis (RA) and its treatment. Questionnaires were administered to 2795 patients with RA (756 from Europe; 2039 from the USA) to measure patients' perceptions regarding pain management in RA. Although the majority of patients reported their RA as somewhat-to-completely controlled, 75% of European and 82% of US patients reported their pain as moderate-to-severe in the previous 2 months. The majority of European (60%) and US (65%) patients reported dissatisfaction with their arthritis pain. Patients' pain levels corresponded with their disease severity. A higher percentage of patients who reported severe pain were being treated for depression than those who had moderate or mild pain. Patients in the USA rated pain relief as the top required benefit from their RA medication. A comprehensive examination of patients' perspectives regarding pain could lead to better patient care and pain management strategies.
Long non-coding RNA FOXD2-AS1 functions as a tumor promoter in colorectal cancer by regulating EMT and Notch signaling pathway.

OBJECTIVE A growing number of long noncoding RNAs (lncRNAs) are emerging as new modulators in cancer origination and progression. However, the functions and molecular mechanisms of lncRNAs to colorectal cancer (CRC) are still largely unknown. The aim of this study was to investigate the function and role of lncRNA FOXD2-AS1 (FOXD2-AS1) in human CRC. PATIENTS AND METHODS The expression of FOXD2-AS1 was investigated using Real-time reverse transcription-polymerase chain reaction (qRT-PCR) in 45 CRC specimens and matched adjacent normal tissues and CRC cell lines. MTT assays were conducted to explore the impact of FOXD2-AS1 knockdown on the proliferation of human CRC cells. The effects of FOXD2-AS1 on CRC cell migration and invasion were evaluated by cell invasion assays and migration assays. Western blot analysis was used to determine the expression levels of EMT-related and Notch-related proteins. RESULTS The results showed that FOXD2-AS1 expression was significantly increased in CRC tissues as well as in CRC cell lines. Moreover, down-regulation of FOXD2-AS1 suppressed cell, proliferation, invasion and migration in vitro. Importantly, we further confirmed that EMT and the Notch signaling pathway were inactivated in CRC cells after FOXD2-AS1 knockdown. CONCLUSIONS FOXD2-AS1 promoted the progression of CRC by regulating EMT and Notch signaling pathway. Thus, targeting FOXD2-AS1 may be an effective strategy for CRC treatment.
A multi-layered controller approach for high precision end-effector control of hydraulic underwater manipulator systems

This paper presents a multi layered control architecture for hydraulic deep-sea manipulators. The proposed architecture is implemented on a Schilling Robotics Orion7P manipulator as example for a widely used deep-sea manipulator. In a number of experiments the improved precision of the new controller is shown. As application example for this improved precision the automated plugging of a deep-sea connector was evaluated and implemented.
A Critical Appraisal of X-Linked Bipolar Illness

The major assumption underlying all X-linkage studies of bipolar disorder has been that a subgroup of manic–depressive illness follows an X-linked dominant mode of inheritance. An evaluation of the segregation patterns in the pedigrees that have been analysed for X-linkage over the past 20 years does not support this assumption, because the formal genetic criteria for an X-linked dominant mode of inheritance are virtually absent. Not a single pedigree has been ascertained in which the segregation pattern is suggestive of the assumed mode of inheritance. This is mainly because segregation ratios characteristic for X-linked dominant inheritance cannot be observed among the offspring of affected males.
From Ford to Faà

1. D. Callan, Pair them up! : A visual approach to the Chung-Feller Theorem, College Math. J. 26 (1995) 196-198. 2. D. Callan, Two uniformly distributed parameters defining Catalan numbers, Amer Math. Monthly 106 (1999) 948-949. 3. W. Feller, An introduction to probability theory and its applications, Vol. 1, John Wiley & Sons, 1950. 4. J. G. Wendel, Left-continuous random walk and the Lagrange expansion, Amer. Math. Monthly 82 (1975) 494-499.
Fibrinolysis: Past and Present, a Reflection of Fifty Years

First, I want to acknowledge my indebtedness to the organizers of the satellite symposium of the Tenth International Congress on Fibrinolysis for their invitation to reflect on the subject of fibrinolysis, an invitation particularly welcomed because it gives an opportunity to recount in a coherent form how our present understanding of fibrinolysis and its role in physiology and pathology evolved. In his book of 1963 Dr. Kurt N. von Kaulla introduced the subject as follows:
Inducibility in Binary Trees and Crossings in Random Tanglegrams

In analogy to other concepts of a similar nature, we define the inducibility of a rooted binary tree. Given a fixed rooted binary tree $B$ with $k$ leaves, we let $\gamma(B,T)$ be the proportion of all subsets of $k$ leaves in $T$ that induce a tree isomorphic to $B$. The inducibility of $B$ is $\limsup_{|T| \to \infty} \gamma(B,T)$. We determine the inducibility in some special cases, show that every binary tree has positive inducibility and prove that caterpillars are the only binary trees with inducibility $1$. We also formulate some open problems and conjectures on the inducibility. Finally, we present an application to crossing numbers of random tanglegrams.
Associations between cigarette smoking, lifestyle factors, and microsatellite instability in colon tumors.

BACKGROUND Microsatellite instability (MSI) has been reported to occur in approximately 10%-15% of colon tumors. MSI is characterized by the presence of mutations in tandemly repeated DNA sequences known as microsatellites. Some individuals with unstable tumors have inherited mutations in mismatch repair genes, but MSI is also observed in sporadic colon cancer. It is unknown whether lifestyle factors associated with colon cancer, such as physical activity, body size, cigarette smoking, or use of aspirin and/or nonsteroidal anti-inflammatory drugs, contribute to MSI in sporadic tumors. METHODS Data from a population-based, case-control study of colon cancer were used. Case subjects were between 30 and 79 years of age at the time of diagnosis and included both men and women. Questionnaire data were used to obtain information on lifestyle factors. Tumor MSI was determined with the use of a panel of 10 tetranucleotide repeats and two mononucleotide repeats. A total of 1510 case subjects had valid questionnaire data and tumor DNA from which we were able to obtain MSI status. Questionnaire data were compared with lifestyle factors reported by 2410 population-based control subjects. All statistical tests were two-sided. RESULTS MSI-positive (MSI(+)) tumors were most common in older people and women and in the proximal colon. Patients with MSI(+) tumors were more likely to smoke 20 or more cigarettes a day than case subjects with MSI-negative (MSI(-)) tumors (odds ratio for being a smoker = 1.6 [95% confidence interval = 1.0-2.5] for men and 2.2 [95% confidence interval = 1.4-3.5] for women). The association between MSI(+) tumors and cigarette smoking was strongest among case subjects who started to smoke at a young age, smoked for 35 or more years, and were either current smokers or had stopped fewer than 15 years before diagnosis. A statistically significant linear trend of increased risk of MSI(+) tumors was observed with increasing amount smoked (P<.01). CONCLUSIONS This study suggests that smoking cigarettes statistically significantly contributes to MSI in colon tumors. We estimate that approximately 21% of MSI in colon tumors may be attributable to cigarette smoking.
Is Inequality Harmful for the Environment? An Empirical Analysis Applied to Developing and Transition Countries

Abstract The object of this article is to examine the relation between social inequalities and pollution. First of all we provide a survey demonstrating that, from a theoretical point of view, a decrease in inequality has an uncertain impact on the environment. Second, on the basis of these conceptual considerations, we propose an econometric analysis based on panel data (fixed-effects and dynamic panel data models) concerning developing and transition countries for the 1988–2003 period. We examine specifically the effect of inequality on the extent of local pollution (sulphur dioxide emissions and organic water pollution) by integrating the Gini index into the formulation of the environmental Kuznets' curve.
A Multicast Routing Algorithm for Datagram Service in Delta LEO Satellite Constellation Networks

Satellites can broadcast datagram over wide areas, therefore, the satellite network has congenital advantages to implement multicast service. LEO satellite has the property of efficient bandwidth usage, lower propagation delay and lower power consumption in the user terminals and satellites. Therefore, the constellation network composed by LEO satellites is an essential part of future satellite communication networks. In this paper, we propose a virtual center based multicast (VCMulticast) routing algorithm for LEO satellite constellation network. The algorithm uses the geographic center information of group users to route multicast datagrams, with less memory, computer power and signaling overhead. We evaluate the delay and performance of our algorithm by means of simulations in the OPENET simulator. The results indicate that the delay of the proposed multicast method exceeds the minimum propagation by at most 29.1% on the average, which is a quite acceptable achievement, considering the resource overhead reduction that can be introduced by our proposal
Adequacy, Nutrition, and Clinical Outcomes

Adequacy, nutrition, and clinical outcomes are three separate and independent aspects ofperi toneal dialysis (PD). They are related, one to the other, but perhaps not as closely as was once thought to be the case. Five years ago, a commonly cited unifying hypothesis was that inadequate clearance on dialysis was the major cause of malnutrition, typically expressed as hypoalbuminemia, and that this malnutrition in turn was the most powerful predictor of adverse outcomes in dialysis patients. Therefore, if higher clearances could be delivered, malnutrition could be re versed and outcomes substantially improved. It is clear that this hypothesis oversimplified a very complicated process. Inadequate dialysis is only one of many causes ofmalnutrition, and it is poorly related to hypoalbuminemia. Outcomes in PD will likely improve when clearances are increased, as appears to have been the case with hemodialysis (HD), but, as presently understood, increased clearances will not cure most malnutrition. If the high rates of morbid ity and mortality seen in dialysis patients are to be improved, a broader approach arising from a better understanding of the pathogenesis of malnutrition and adverse outcomes will be required. In this paper, major developments in these three areas of adequacy, nutrition, and outcomes since the last International Society ofPeritoneal Dialysis meeting in 1995 will be highlighted to put our present state of knowledge into perspective.