Miracle-dz/UniFAR-FTUs huggingface dataset:
A retrospective view of electronic word-of-mouth in hospitality and tourism management

Purpose The purpose of this paper is to review the impact electronic word-of-mouth (eWOM) has had on the hospitality and tourism industry and to discuss changes that will affect its future. The paper’s touchpoint is our earlier paper (Litvin et al., 2008), which proposed that eWOM was to become a major influence as a conduit of travelers’ views and opinions. Design/methodology/approach The article summarizes arguments in our earlier paper, describing ways in which eWOM has evolved into the influential system it has become, with special emphasis on the growth of mobile media as a platform for eWOM dissemination. Findings We conclude that eWOM has fulfilled its promise to become a major influence on the hospitality and tourism industry and will continue to play an essential role in hospitality marketing for the foreseeable future. Practical implications We provide examples of successful media campaigns and propose strategies for hospitality and tourism businesses. Originality/value eWOM has emerged to becom.
Is the incidence of rheumatoid arthritis rising?: results from Olmsted County, Minnesota, 1955-2007.

OBJECTIVE To examine trends in the incidence and prevalence of rheumatoid arthritis (RA) from 1995 to 2007. METHODS To augment our preexisting inception cohort of patients with RA (1955-1994), we assembled a population-based incidence cohort of individuals >or=18 years of age who first fulfilled the American College of Rheumatology 1987 criteria for the classification of RA between January 1, 1995 and December 31, 2007 and a cohort of patients with prevalent RA on January 1, 2005. Incidence and prevalence rates were estimated and were age-and sex-adjusted to the white population in the US in 2000. Trends in incidence rates were examined using Poisson regression methods. RESULTS The 1995-2007 incidence cohort comprised 466 patients (mean age 55.6 years), 69% of whom were female and 66% of whom were rheumatoid factor positive. The overall age- and sex-adjusted annual RA incidence was 40.9/100,000 population. The age-adjusted incidence in women was 53.1/100,000 population (versus 27.7/100,000 population in men). During the period of time from 1995 to 2007, the incidence of RA increased moderately in women (P = 0.02) but not in men (P = 0.74). The increase was similar among all age groups. The overall age- and sex-adjusted prevalence on January 1, 2005 was 0.72% (95% confidence interval [95% CI] 0.66, 0.77), which is an increase when compared with a prevalence of 0.62% (95% CI 0.55, 0.69) in 1995 (P < 0.001). Applying the prevalence on January 1, 2005 to the US population in 2005 showed that an estimated 1.5 million US adults were affected by RA. This is an increase from the previously reported 1.3 million adults with RA in the US. CONCLUSION The incidence of RA in women appears to have increased during the period of time from 1995 to 2007. The reasons for this recent increase are unknown, but environmental factors may play a role. A corresponding increase in the prevalence of RA was also observed.
Use of Mobile Phones, Computers and Internet Among Clients of an Inner-City Community Psychiatric Clinic

Objective. Recent years have witnessed an expansion of Internet- and mobile-phone-based interventions for health promotion, yet few studies have focused on the use of technology by individuals with mental illness. This study examined the extent to which patients at an inner-city community psychiatry clinic had access to information and communications technology (ICT) and how they used those resources. Methods. Patients of an outpatient, inner-city community psychiatry program (N=189) completed a survey that included questions about demographics and ICT use which were adapted from an existing local population-based health survey (community sample, N=968). Frequencies of ICT use were assessed for the clinic sample and questions common to both the surveys completed by the clinic and community samples were compared using logistic regression. Results. Among clinic cases, 105 (55.6%) reported owning or using a computer, 162 (85.7%) reported owning or using a mobile phone, and 112 (59.3%) reportedf using the Internet. Among those who used mobile phones, the majority reported using them daily; 42% of those who used the Internet reported using it several times per day. Differences in frequency of Internet use between samples were not significant, but clinic participants used the Internet more intensively to email, instant message, access health information, and use social media sites. Conclusions. A majority of patients in this community psychiatry clinic sample use ICT. Greater access to and use of the Internet by those with mental illness has important implications for the feasibility and impact of technology-based interventions. (Journal of Psychiatric Practice 2014;20:94–103)
Flexion-Distraction Injuries of the Subaxial Cervical Spine

Abstract Flexion-distraction injuries are among the most common mechanisms for subaxial cervical trauma. There is a high risk of neurological compromise with these injuries. The history and examination of injuries are essential components that should be performed on all patients. Imaging should include plain radiographs, computed tomography, and magnetic resonance imaging for diagnosis and treatment planning. Early closed reduction may be performed on awake cooperative patients. Anterior or posterior stabilization may be used, although anterior fixation alone has higher failure rates in the setting of a concurrent vertebral body fracture. Although functional and neurological status can improve, particularly after operative intervention, flexion-distraction injuries affect patient's health-related quality of life and outcome long after the injury. Prompt and accurate diagnosis of the osseous, ligamentous, disk, and neurologic components of the injury will provide the best patient outcome.
HLA‐Cw4 expression on porcine endothelial cells reduces cytotoxicity and adhesion mediated by CD158a+ human NK cells

Abstract: Background: Human natural killer (NK) cell‐mediated cytotoxicity represents a hurdle in pig‐to‐human xenotransplantation. It was previously reported that the expression of human major histocompatibility complex class I molecules, including HLA‐B27, ‐Cw3, ‐E, and ‐G, partially protects porcine endothelial cells (pEC) from human NK‐mediated cytotoxicity and that HLA‐G inhibits NK adhesion to pEC. Here, we tested if HLA‐Cw4 expression on pEC alone, or concurrently with HLA‐Cw3, prevents human NK adhesion and cytotoxicity against pEC via recognition of the killer‐cell immunoglobulin‐like receptors (KIR) CD158a (KIR2DL1) and CD158b (KIR2DL2/3), respectively.
Gender and Nasal Shape: Measures for Rhinoplasty

Background: Gender-specific nasal shapes are recommended for rhinoplasty. This study was conducted to clarify whether there truly are gender-related differences and to determine optimal nasal shapes in a Caucasian population. Methods: The authors created female and male composite photographs of “average” (n = 128 each), “optimal” (n = 16 each), and “most unpleasant” (n = 8 each) noses stratified on the basis of each photographed subject’s (n = 311) own evaluation of the attractiveness of her or his nose, using a visual analogue scale. These composites were also assessed by 308 independent judges. Results: Optimal female noses showed a horizontally and vertically lower nasion and were concave to straight in profile as compared with optimal male noses, which had a vertically and horizontally higher nasion and a straight profile. A supratip break was not found in any of the composites. At least half of the judges rated average and optimal male composite noses as female. A significant majority mistook the composite of the most unpleasant female noses as male (frontal view, 62.0 percent; lateral view, 72.4 percent; p < 0.001). Optimal and average female and male noses were found to be independently significantly more attractive than the most unpleasant ones (p < 0.001, n = 308 judges). Women and men with a straight or concave profile were significantly (p = 0.017 and p = 0.006, respectively) more satisfied with the appearance of their nose than those with nasal humps. Conclusions: Gender-related differences in nasal shape appear to be subtle, with nasion position being one of the main factors. A nasal hump and a supratip break are not desirable.
Clinical Strategies for Managing Dental Caries in Egypt: Opinions of General Practitioner Dentists

Background: To assess the approach of GPDs in Upper Egypt regarding preventive and restorative treatments for various stages of carious lesion development. Methods: A 42-item questionnaire was constructed for obtaining the GPDs opinions. Factor analyses (with Varimax rotation) were conducted to identify scales (clusters) of variables . Logistic regression analyses, with continuing professional development as dependen t variable, were conducted to test for the effect of single and scaled factors regarding indications to perform preventive or restorative treatments. Original ResearchArticle
Effect of Alternate Nostril Breathing on Cardiovascular Parameters in Obese Young Adults

Obesity is common problem in young adults of high socioeconomic status. In association with stress, it predisposes them at a high risk for development of hypertension and other cardiovascular diseases at a very young age. Alternate nostril breathing (ANB) is a pranayama yogic exercise, deemed to relieve stress and related disorders. Present study was conducted to assess the effect of alternate nostril breathing on cardiovascular parameters in obese young adults belonging to high socioeconomic status. Sixty asymptomatic healthy male subjects, aged 25–35 years, participated voluntarily in the present study. Based on BMI, subjects were divided into two groups. Group -A comprised of non-obese subjects (BMI 30). Systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) were recorded by using automatic digital sphygmomanometer before and after Alternate Nostril Breathing (ANB) exercise of 15 minutes. Data obtained were analyzed using paired t-test. Statistically significant decrement was observed in all cardiovascular parameters viz. Systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) after ANB exercise in both groups A & B. However decrease in all these parameters was more significant in obese subjects of group –B.
This item is the archived peer-reviewed author-version of: Determining and benchmarking risk neutral distributions implied from option prices

Risk neutral probability density functions (RNDs) play a central role in assessing models for stock market behaviour. However, it remains challenging to distill a realistic estimate for the RND from empirical data. In this work we introduce a novel method to infer a RND estimate from observed option prices. Our method eﬃciently yields a realistic rational function approximation to the RND, it is ﬂexible w
Comparison of immunogenicity and porcine‐to‐rhesus lamellar corneal xenografts survival between fresh preserved and dehydrated porcine corneas

Li A, Pan Z, Jie Y, Sun Y, Luo F, Wang L. Comparison of immunogenicity and porcine‐to‐rhesus lamellar corneal xenografts survival between fresh preserved and dehydrated porcine corneas. Xenotransplantation 2011; 18: 46–55. © 2011 John Wiley & Sons A/S.
Determinants of Formal Service Use in an Aged Population

The factors distinguishing users of formal services from comparable non-users were examined using a random sample of 1,799 people aged 70 years and over. One person in eight in the aged population received services from Domiciliary Care and Rehabilitation Services, Royal District Nursing Society, or Meals on Wheels. Service use was associated with greater age, fewer assets, living alone, ADL and IADL problems, poor self-rated health, more health consultations, and recent hospitalisation. Agencies appeared to be accurately allocating services to those most in need. Longitudinal data will enable refinement of the profile of those people requiring new or ongoing services.
Age and HIV Risk and Protective Behaviors Among African American Women

Though HIV prevention efforts have focused on young adult women, women of all ages may engage in HIV risk behaviors and experience barriers to condom use. This article examines the effect of age on sexual risk and protective attitudes and behaviors among African American women. Unmarried heterosexual African American women between the ages of 18 and 61 completed pen-and-paper survey measures. Participants were recruited from three local colleges and universities and several community-based agencies including health clinics, faith-based institutions, social service agencies, and other community-based organizations in a southeastern metropolitan area. Results indicated that as age of participants increased, participants reported less frequent condom use, reported lower condom use intentions, and perceived their partner's attitudes toward condoms to be less favorable, even after controlling for the effects of relationship length, education, and partner status. As age increased, participants reported higher condom negotiation efficacy. Findings suggest that older, sexually active heterosexual women may be at higher risk than younger women for sexually transmitted infections associated with lack of condom use.
Therapeutic effect of tolerogenic dendritic cells in established collagen-induced arthritis is associated with a reduction in Th17 responses.

OBJECTIVE Tolerogenic dendritic cells (DCs) are antigen-presenting cells with an immunosuppressive function. They are a promising immunotherapeutic tool for the attenuation of pathogenic T cell responses in autoimmune arthritis. The aims of this study were to determine the therapeutic action of tolerogenic DCs in a type II collagen-induced arthritis model and to investigate their effects on Th17 cells and other T cell subsets in mice with established arthritis. METHODS Tolerogenic DCs were generated by treating bone marrow-derived DCs with dexamethasone and vitamin D(3) during lipopolysaccharide-induced maturation. Mice with established arthritis received 3 intravenous injections of tolerogenic DCs, mature DCs, or saline. Arthritis severity was monitored for up to 4 weeks after treatment. Fluorescence-labeled tolerogenic DCs were used for in vivo trafficking studies. The in vivo effect of tolerogenic DCs on splenic T cell populations was determined by intracellular cytokine staining and flow cytometry. RESULTS Tolerogenic DCs displayed a semi-mature phenotype, produced low levels of inflammatory cytokines, and exhibited low T cell stimulatory capacity. Upon intravenous injection into arthritic mice, tolerogenic DCs migrated to the spleen, liver, lung, feet, and draining lymph nodes. Treatment of arthritic mice with type II collagen-pulsed tolerogenic DCs, but not unpulsed tolerogenic DCs or mature DCs, significantly inhibited disease severity and progression. This improvement coincided with a significant decrease in the number of Th17 cells and an increase in the number of interleukin-10-producing CD4+ T cells, whereas tolerogenic DC treatment had no detectable effect on Th1 cells or interleukin-17-producing γ/δ T cells. CONCLUSION Treatment with type II collagen-pulsed tolerogenic DCs decreases the proportion of Th17 cells in arthritic mice and simultaneously reduces the severity and progression of arthritis.
The effects of need for achievement and need for independence on the relationship between perceived job attributes and managerial satisfaction and performance.

Work-manifest needs for achievement and independence were examined as moderators of relations between perceptions of five job attributes (skill variety, task identity, task significance, autonomy and feed-back) and job satisfaction and job performance among a sample of 346 middle-managers. Need for achievement and need for independence were unrelated to the perceived job attributor and to both job satisfaction and job performance. However, most of the relations between the perceived job attributes and both job satisfaction and job performance were significantly higher among the managers high in need for achievement and need for independence than among those low in these needs. These results point to the importance of differentiating between managers high and low in these needs when redesigning jobs.
Pattern on the antinuclear antibody-HEp-2 test is a critical parameter for discriminating antinuclear antibody-positive healthy individuals and patients with autoimmune rheumatic diseases.

OBJECTIVE To identify features of antinuclear antibody (ANA)-HEp-2 test results that discriminate ANA-positive healthy individuals and patients with autoimmune rheumatic diseases (ARDs). METHODS We sequentially retrieved data on 918 healthy individuals and 153 patients with ARDs after clinical assessment. ANA-positive healthy individuals for whom data were available were reevaluated after 3.6-5.0 years. An ANA-HEp-2 test result was considered positive when a clear ANA pattern was observed at 1:80 dilution in 2 distinct commercial HEp-2 slides by 2 blinded independent observers. RESULTS ANAs were present in 118 healthy individuals (12.9%) and 138 patients with ARDs (90.2%). The ANA titer was higher in patients with ARDs than in healthy individuals (P<0.001). The ANA pattern profile was distinct in the 2 groups. Nuclear homogeneous, nuclear coarse speckled, and nuclear centromeric patterns appeared exclusively in patients with ARDs. The nuclear dense fine speckled pattern occurred only in healthy individuals. The most frequent ANA pattern in both groups was the nuclear fine speckled pattern, which occurred at lower titer in healthy individuals than in patients with ARDs (P<0.001). Anti-extractable nuclear antigen was present in 1 healthy individual (anti-SSA/Ro) and in 52 patients with ARDs (37.7%). None of the 40 reevaluated healthy individuals developed ARDs, and 29 (72.5%) remained ANA positive. All healthy individuals who became ANA negative had an ANA titer of 1:80 at baseline. CONCLUSION Our findings suggest that the titer, and especially the pattern, on the ANA-HEp-2 test strongly enhances our ability to discriminate ANA-positive healthy individuals and patients with ARDs.
Th17 cells, but not Th1 cells, from patients with early rheumatoid arthritis are potent inducers of matrix metalloproteinases and proinflammatory cytokines upon synovial fibroblast interaction, including autocrine interleukin-17A production.

OBJECTIVE Both Th1 cells and Th17 cells have been recognized in rheumatoid arthritis (RA); however, it remains unclear whether Th1 cells and/or Th17 cells are involved in driving disease chronicity and destructiveness. The aim of this study was to identify and characterize the functional role of Th17 cells in early RA. METHODS Flow cytometry analysis was performed on peripheral blood mononuclear cells (PBMCs) from treatment-naive patients with early RA and age-matched healthy volunteers. PBMCs from these patients, naive T cells, and primary CCR6- Th1 cells and CCR6+ Th17 cells were sorted and cultured in the absence or presence of synovial fibroblasts from patients with early RA (RASFs), and cytokine expression and gene transcription were analyzed. In addition, tumor necrosis factor α (TNFα)- and interleukin-17A (IL-17A)-blocking experiments were performed. RESULTS In the PBMCs of treatment-naive patients with early RA, an increased fraction of IL-17A-and TNFα-producing CCR6+ Th17 cells was observed. When cocultured with RASFs, these primary Th17 cells were potent inducers of IL-6 and IL-8 and the tissue-destructive enzymes matrix metalloproteinase 1 (MMP-1) and MMP-3, whereas primary Th1 cells or naive T cells were not. Importantly, specific up-regulation of IL-17A but not TNFα or interferon-γ was observed in RASF/Th17 cell cocultures. In addition to TNFα blocking, IL-17A neutralization was required to further down-regulate Th17 activity in RASF/Th17 cell cocultures. CONCLUSION Th17 cells, but not Th1 cells, cooperated with RASFs in a proinflammatory feedback loop, revealing a potential mechanism by which human Th17 cells drive chronic destructive disease in patients with RA. Furthermore, the neutralization of IL-17A activity is essential in current anti-TNF therapies to suppress Th17 cell activity in patients with early RA and potentially other Th17 cell-mediated disorders.
The benefit of targeted and selective inhibition of the alternative complement pathway for modulating autoimmunity and renal disease in MRL/lpr mice.

OBJECTIVE Complement has both protective and pathogenic functions in lupus due to a balance between its role in the clearance of immune complexes (ICs) and apoptotic cells and its role in inflammation. The classical pathway contributes to IC and apoptotic cell clearance, whereas the alternative pathway is a key mediator of renal inflammation. The aim of this study was to investigate the effect of a new targeted inhibitor of the alternative pathway, CR2-fH, on lupus-like renal disease in MRL/lpr mice. METHODS Mice were treated with either saline, CR2-fH, CR2-Crry (which inhibits all complement pathways), or soluble CR2 (sCR2; C3d-binding targeting vehicle). Sera were analyzed every 2 weeks for autoantibodies, circulating ICs, and C3. Urinary excretion of albumin was also determined, and kidneys were collected at 23 weeks for histologic evaluation. RESULTS Treatment with CR2-fH or CR2-Crry improved survival and significantly reduced proteinuria, glomerular C3 deposition, and the level of circulating ICs. CR2-fH, but not CR2-Crry, also significantly reduced glomerulonephritis, expression of serum anti-double-stranded DNA (anti-dsDNA) antibodies, and glomerular IgG and C1q deposition. Interestingly, sCR2 also significantly reduced the levels of anti-dsDNA antibodies and circulating ICs and reduced glomerular deposition of IgG, C1q, and C3, although there was no significant reduction in glomerulonephritis, proteinuria, or mortality. CONCLUSION Targeted and selective inhibition of the alternative complement pathway is an effective treatment of murine lupus and is more effective than blockade of all pathways. The data demonstrate benefits to leaving the classical/lectin pathways intact and indicate distinct roles for the classical and alternative pathways of complement in disease progression. The sCR2-targeting vehicle contributes to therapeutic activity, possibly via modulation of autoimmunity.
Impact of socio-cultural factors, dietary habits, and lifestyle patterns on the health status of North African migrants in France

Abstract The available studies in France showed a paradox among North African migrant men in France and some other developed countries, i.e., that migration could have a protective effect against some nutrition-related noncommunicable diseases compared to French. The origin of this paradox is not well documented. Particular attention was given to the influence of socio-cultural and environmental factors on health status of North African migrants. Conservation of healthy diet habits, lower prevalence of smoking, lower alcohol consumption, and adoption of a more active lifestyle may confer protective effects on morbidity and mortality of North African men compared to local-born French. It should be noted however that beneficial effects of migration in men would be expected to decrease with the length of stay in the host country because of acculturation to the host country lifestyle. More comprehensive and larger-scale studies will be required to provide a better insight into migration-health relationships.