Miracle-dz/UniFAR-FTUs huggingface dataset:
HDAC6 regulates 14-3-3ζ via deacetylation

The phospho-binding protein 14-3-3ζ acts as a signaling hub controlling a network of interacting partners and oncogenic pathways. We show here that lysines within the 14-3-3ζ binding pocket and protein-protein interface can be modified by acetylation. The positive charge on two of these lysines, K49 and K120, is critical for coordinating 14-3-3ζphosphoprotein interactions. Through screening, we identified HDAC6 as the K49/K120 deacetylase. Inhibition of HDAC6 blocks 14-3-3ζ interactions with two welldescribed interacting partners, Bad and AS160, which triggers their dephosphorylation at S112 and T642, respectively. Expression of an acetylation-refractory K49R/K120R mutant of 14-3-3ζ rescues both the HDAC6 inhibitorinduced loss of interaction and S112/T642 phosphorylation. Furthermore, expression of the K49R/K120R mutant of 14-3-3ζ inhibits the cytotoxicity of HDAC6 inhibition. These data demonstrate a novel role for HDAC6 in controlling 14-3-3ζ binding activity. The 14-3-3 protein family includes seven human isoforms that regulate diverse processes, including metabolism, cell cycle control, protein trafficking, cell motility, and apoptosis. While these functions are somewhat dispersed between the different isoforms, the zeta (ζ) isoform plays a prominent http://www.jbc. org/cgi/doi/10.1074/jbc.M114.607580 The latest version is at JBC Papers in Press. Published on March 13, 2015 as Manuscript M114.607580 Copyright 2015 by The American Society for Biochemistry and Molecular Biology, Inc. by gest on M arch 2, 2020 hp://w w w . jb.org/ D ow nladed from HDAC6 regulates 14-3-3ζ via deacetylation
THE COMPLEXITIES AT THE INTERFACE AMONG DOMESTIC/WILD RODENTS, FLEAS, PETS, AND MAN IN URBAN PLAGUE ECOLOGY IN LOS ANGELES, COUNTY, CALIFORNIA

Author(s): Nelson, Bernard C. ; Madon, Minoo B. ; Tilzer, Arthur | Abstract: Bubonic plague was first found in Los Angeles County in 1908. The largest epidemic of pneumonic plague in the United States occurred in the county in 1924, and the last cases of plague associated with domestic rodents in the United States occurred here in 1925. Sporadic plague activity was recorded from 1925 to 1975. Since 1975, plague has been found annually and is now endemic in the San Gabriel Mountains and the interface, that area where suburban encroachment intermingles with wilderness areas along the southern edge of these mountains. Within these two areas, plague is amplified and is a risk to humans when it occurs in the California ground squirrel, Spermophilus beecheyi. This rodent has been implicated directly in two human cases and is now peridomestic throughout most of the interface area. A domestic cat was implicated with another case; the role of domestic pets in plague ecology is discussed. Although large populations of Rattus rattus exist within the interface, they currently play no role in plague ecology due to the virtual absence of fleas. The oriental rat flea, however, is seasonally very abundant in Rattus norvegicus living adjacent to the interface area and poses an alarming potential for epidemics if plague ever was introduced into this host population. The plague surveillance program in Los Angeles County centers on an active intelligence network to report signs of plague activity and on the combined use of serologies taken from wild carnivores and S. beecheyi. Early detection by these means plus active flea and ground squirrel suppression programs have been implemented to reduce plague activity and prevent human cases.
Industry Strength Tool and Technology for Automated Synthesis of Safety-Critical Applications from Formal Specifications

Abstract : This report discussed the fundamental theory, algorithms, and prototype tools for the synthesis of embedded safety-critical software for multi-core embedded platforms as well as to initiate planned technology transfer to a Department of Defense (DoD) vender company. The techniques and tools developed during project execution will enable the production of embedded safety -critical software with improved quality and performance, decreases in cost and development times, automation of labor-intensive and error -prone processes, increased reliability, and easier integration and sustainment.
Gender Differences in Undergraduate Engineering Applicants: A Text Mining Approach

It is well known that post-secondary science and engineering programs attract fewer female students. In this paper, we analyze gender diﬀerences through text mining of over 30,000 applications to the engineering faculty of a large North American university. We use syntactic and semantic analysis methods to highlight diﬀerences in motivation, interests and background. Our analysis leads to three main ﬁndings. First, female applicants demonstrate a wider breadth of experience, whereas male applicants put a greater emphasis on technical depth. Second, more female applicants demonstrate a greater desire to serve society. Third, female applicants are more likely to mention personal inﬂuences for studying engineering.
The 2MASS red AGN survey

The Two Micron All Sky Survey (2MASS) provides an unprecedented, uniform photometric data set for large samples of AGN discovered at other wavelengths, and also forms the basis to search for previously unknown, obscured AGN. We present the results of a highly efficient near infrared color-based AGN survey using 2MASS that has already discovered 485 new, red AGN and QSOs. The extrapolated surface density of the 2MASS red AGN is ~0.57 deg~ −2 for K s ≤15.5 mag. The ratio of Type 1 to Type 2 AGN among the newly discovered objects is 4:1, similar to proportions found in X-ray and deep ISO surveys, but the inverse of that found in IRAS surveys. The median redshift of the the new 2MASS red AGN sample is z
Multi-party protocol with access control on symmetric fully homomorphic encryption scheme

Homomorphic encryption is a particular class of encryption presented by Rivest, Adleman et al. in 1978 that permits mathematical operations on the encrypted data without decrypting it [1], in fact, without knowing the decryption key. In the last few years, homomorphic encryption techniques have been studied deeply since they have become more and more vital and important in several different cryptographic applications such as lottery protocols, voting protocols, anonymity, privacy, and electronic auctions. This paper introduces the symmetric fully homomorphic scheme (Sym-FHE) and multi-party protocol with access control to allow many users access and manipulate the data in the cloud without violating the confidentiality of sensitive data.
An algorithm for removing sensitive information: Application to race-independent recidivism prediction

Predictive modeling is increasingly being employed to assist human decision-makers. One purported advantage of replacing or augmenting human judgment with computer models in high stakes settings-- such as sentencing, hiring, policing, college admissions, and parole decisions-- is the perceived "neutrality" of computers. It is argued that because computer models do not hold personal prejudice, the predictions they produce will be equally free from prejudice. There is growing recognition that employing algorithms does not remove the potential for bias, and can even amplify it if the training data were generated by a process that is itself biased. In this paper, we provide a probabilistic notion of algorithmic bias. We propose a method to eliminate bias from predictive models by removing all information regarding protected variables from the data to which the models will ultimately be trained. Unlike previous work in this area, our framework is general enough to accommodate data on any measurement scale. Motivated by models currently in use in the criminal justice system that inform decisions on pre-trial release and parole, we apply our proposed method to a dataset on the criminal histories of individuals at the time of sentencing to produce "race-neutral" predictions of re-arrest. In the process, we demonstrate that a common approach to creating "race-neutral" models-- omitting race as a covariate-- still results in racially disparate predictions. We then demonstrate that the application of our proposed method to these data removes racial disparities from predictions with minimal impact on predictive accuracy.
Force-Based Control of a Six-Legged Robot on Abrupt Terrain using the Subsumtion Architecture

We have developed a controller for a six-legged robot that allows it to walk on rough or even abrupt terrain using only force sensors as feedback. In an initial approach, which at rst seemed natural, we took a subsumption-based controller tailored to walk on at surfaces and tried to add a force-compliance layer on top of it, thus maintaining the modularity of the design and building the controller in a purely incremental way, as proposed by Brooks in [1]. However, this approach could not be followed without making substantial modi cations in the existing layers, in contradiction with our requirement of incrementality. Modularity was also lost, since lower levels of competence depended on the upper ones to work. A solution to these problems was found by redesigning the layer structure into a new one in which (compliant) walking corresponds to the uppermost level of competence, and in which a level for non-compliant walking has been ruled out.
Frankincense (Heaven’s Gift) — Chemistry, Biology, and Clinical Applications

Frankincense, gold, and myrrh were the three gifts from the wise men (the Magi, or the three kings) brought from the East to celebrate the birth of baby Jesus Christ (Bible, Matthew 2:11) According to the Christian belief (Botros et.al. 2003). Nine compounds with immunostimulant and antiviral activity were isolated from the oleogum resin of frankincense (Boswellia carterii Birdwood). The frankincense essential oil (3%) found to contain monoterpenes (13.1 %), sesquiterpenes (1 %), and diterpenes (42.5 %). Both isolated oil and resins exhibited strong immunostimulant activity. Badria et al. (2003) proved that the of boswellia, curcumin, and glycyrrhizin exhibited the highest activity against Herpes simplex virus. However, boswellia extract retained a significant increase in both FEV1 and PEFR (P ≤ 0.05 and ≤ 0.01 respectively) with no significant change in FVC in the severe persistent bronchial asthma (Badria et. al. 2003). Boswellia-Curcumin preparation was investigated clinically for treatment of knee osteoar‐ thirits (Badria et. al. 2002). Meanwhile, glycyrrhizin, curcumin and Boswellia carterii formula exhibited a hepatoprotective effect and used as endogenous interferon inducer, demonstrating that two phases of the induction of IFN in serum takes place; the induced IFN was regarded as IFN-γ. This induction may be followed by activation of macrophages and augmentation of natural killer (NK) activity through the action of the induced IFN (Badria 2001). This combi‐ nation was successfully tried in a clinical study as endogenous interferon inducer for treatment of hepatitis C (Badria 2001).
Assessment of Social Vulnerability to Flood in Urban Côte d’Ivoire Using the MOVE Framework

Coupled with poor urban development, the increasing urban population of many Sub-Saharan African countries is subject to recurrent severe flooding episodes. In response to these flood events, while the focus is often put on slums and precarious urban settings, the social implications of these floods affect a variety of social classes. Presenting a case study of Cocody, a district of Abidjan, Cote d’Ivoire, known to have the country’s highest number of flood-impacted people, this paper evaluates the social vulnerability of urban Cote d’Ivoire to flooding using the MOVE framework. The MOVE framework (Method for the Improvement of Vulnerability Assessment in Europe) has successfully been used in European contexts to assess social vulnerability of urban areas to geo-environmental disasters such floods. It helped assess the major factors involved in the social vulnerability to urban flooding and to have a good appreciation of the spatial distribution of areas that are vulnerable to urban flood. By taking this framework to the local context, relevant indicators were developed and GIS applications were used to assess spatially the relative social vulnerability of Cocody sub-districts to urban flooding. The results revealed that many sub-districts of Cocody are highly vulnerable to urban floods. Exposure and susceptibility are components that are found to have high influence on vulnerability to flood hazard in the district of Cocody. Their respective indicators need to be addressed properly in order to increase residents’ resilience to urban flooding. The MOVE theoretical framework can be applied in Africa by contextualizing the vulnerability by using local indicators.
SPEARHEADING DEVELOPMENT THROUGH EMPOWERING SMALLHOLDER FARMERS ALONG BEEF CATTLE VALUE CHAINS: A CASE OF GOROMONZI AND MUREHWA DISTRICTS, ZIMBABWE

Smallholder beef subsector can potentially contribute to the nation’s development. The paper presents the results of the value chain analysis of the beef sub sector in Zimbabwe. Data was gathered through cross sectional household survey of 380 beef farmers, six community focus group discussions, key informant interviews and interviews of value chain actors. Empirical results showed that profitability of beef marketing by farmers is constrained by low productivity caused by longer calving intervals, poor animal husbandry practices and lack of market information . Three existing beef cattle value chains were identified. A total of 91% of the producers sold cattle to the informal livestock market and only 9% through formal market. Body condition, health of animal and age were reported as major factors used in setting cattle prices. The study recommends setting up breeding programs, improved husbandry practices, improving farmer access to market information and collective action among farmers.
Elevated Activity Levels of Serum Antimicrobial Peptides in Mice as Response to Immunization with Yeast Antigens

Except immunoglobulins and components of complement system, the important part of congenital humoral immunity are antimicrobial (poly) peptides (AMP). Main antimicrobial mechanism of AMP action is the destruction of cytoplasmic membrane. In host organism number of AMP act simultaneously, therefore method for the measuring of overall AMP activity would be helpful. The method was recently applied and modified for estimation of AMP activity in serum: aliquots of low-molecular fraction of serum added to test-culture of Candida albicans, and the part of killed cells, i.e. total activity of AMP, calculated by spectroscopy. Aim of present study is the estimation of AMP activity in mice sera after immunization with cells of clinical yeasts compare to the immunoglobulins G. Yeasts strains-Candida albicans, Cryptococcus neoformans, Rhodotorula mucilaginosa, Trichosporon cutaneum, Geotrichum candidum, and Saccharomyces cerevisiae-were cultivated in liquid defined media up to the end of exponential growth phase. Obtained yeasts cells used for immunization of mice, but yeast antigens-for the estimation of IgG-antibodies levels in mice sera by ELISA method. AMP activity were measured as described above. Immunization of mice with yeasts cells was accompanied not only with increase of specific IgG levels, but with elevation of total activity of AMP: for example specific IgG in sera of mice immunized by C. albicans cells was 16-fold higher than in non-immunized (control), and AMP activity-1,5 fold higher than in control. Correlation between specific humoral response at the immunoglobulins level and humoral response at the AMP-activity level (Pirson`s coefficient r=0,735; p ≤ 0,05) as a result of immunization of mice by fungal cells was demonstrated for the first time. The method may be used for study of humoral immunity associated with action of AMP in various animal and human models.
Tree-ring width and Variation of Wood Density in Fraxinus excelsior L. and Quercus robur L. Growing in Floodplain Forests

Oven-dry wood density variations are reported for European ash (Fraxinus excelsior L.) and English oak (Quercus robur L.) trees growing in floodplain mixed forests in South Moravia, Czech Republic. Two sites with different water regime conditions were selected along the Dyje (site A) and the Morava (site B) Rivers. In total, 20 dominant, healthy trees were chosen to determine the tree-ring structure and the oven-dry wood density (ρ0) along the radius of the stem cross section. The tree-ring width followed the common trend of a general decline as the trees aged. After removing the age influence, significant differences were observed in the tree-ring structure, recorded several years after water regime treatments. The European ash and the English oak ρ0 were found to be 677.3 kg∙m-3 and 618.2 kg∙m-3, respectively, significantly differing between the sites, for both species. High variability of ρ0 was also noticed along the stem radius in both species and sites.
Fast deformation of perennially frozen debris in a warm rock glacier in the Swiss Alps: An effect of liquid water

[1] Surface movement, internal deformation, and temperature were monitored over 5 years on Buz North rock glacier, a small rock glacier located at the lower limit of the permafrost belt in the Swiss Alps. The permafrost in the rock glacier mainly consists of pebbles and cobbles filled with interstitial ice. Two inclinometers installed at 4 and 5 m depths showed fast deformation with large seasonal and interannual variations, while the permafrost temperatures remained almost at the melting point. The movement of the inclinometers coincided with changes in the surface velocities. The deformation rapidly accelerated during snowmelt periods, whereas it gradually decelerated below a dry snow cover in winter. The frozen debris was more deformable than typical glacier ice at the melting point. These phenomena suggest that the frozen debris is permeable to snowmelt water. The fast deformation should result from significant annual relocation of debris particles, which probably creates a network of air voids in the frozen debris that eventually allows water infiltration. The meltwater infiltration accelerates the deformation by reducing effective stress, resulting in the reduced strength of the frozen debris. The refreezing of the pore water, which depends on the cooling intensity in winter, decelerates the deformation. The combination of these processes controls the temporal variations in the deformation.
A FRAMEWORK FOR THE AUTOMATIC DISCOVERY OF POLICY FROM HEALTHCARE ACCESS LOGS By

ing the Low-Level Network into a Generalized Network While examining how specific providers interact within the system is informative, this provider-level model can be very brittle when modeling modern HCOs due to the way in which providers act in roles and teams. For instance, if a patient is being treated in an Intensive Care Unit, it may be more informative to know that a critical care nurse accessed the record than to know the particular identity of the nurse. Understanding who the providers are at an abstracted level empowers our model to make broader generalizations of the HCO. Additionally, these abstractions could potentially smooth volatility from the model. For example, several nurses and fellows may perform the same actions on the same set of patients but work at different times of the day. At the user level, we will detect different clusters of relationships depending on the time of day. But if we abstract the data appropriately, we could remove the time factor to study true care roles. We can construct abstracted versions of the relational network if, in addition to the access logs, we have a mapping of the users to some generalization, such as their department (Critical Care, Medicine, Oncology, etc.) or their role (fellow, nurse, biller).
Cold-gas outflows in typical low-redshift galaxies are driven by star formation, not AGN

Energetic feedback from active galactic nuclei (AGN) is an important ingredient for regulating the star formation history of galaxies in models of galaxy formation, which makes it important to study how AGN feedback actually occurs in practice. In order to catch AGNs in the act of quenching star formation, we have used the interstellar Na ɪ λλ5890, 5895(NaD) absorption lines to look for cold-gas outflows in a sample of 456 nearby galaxies for which we could unambiguously ascertain the presence of radio-AGN activity, thanks to radio imaging at milli-arcsecond scales. While compact radio emission indicating a radio AGN was found in 103 galaxies (23 per cent of the sample), and 23 objects (5 per cent) exhibited NaD absorption-line kinematics suggestive of cold-gas outflows, not one object showed evidence of a radio AGN and of a cold-gas outflow simultaneously. Radio-AGN activity was found predominantly in early-type galaxies, while cold-gas outflows were mainly seen in spiral galaxies with central star formation or composite star formation/AGN activity. Optical AGNs also do not seem capable of driving galactic winds in our sample. Our work adds to a picture of the low-redshift Universe, where cold-gas outflows in massive galaxies are generally driven by star formation and where radio-AGN activity occurs most often in systems in which the gas reservoir has already been significantly depleted.
A Single Amino Acid Substitution in an ORANGE Protein Promotes Carotenoid 18 Overaccumulation in Arabidopsis

A single amino acid substitution in an OR protein ABSTRACT Carotenoids are crucial for plant growth and human health. The finding of ORANGE 54 (OR) protein as a pivotal regulator of carotenogenesis offers a unique opportunity to 55 comprehensively understand the regulatory mechanisms of carotenoid accumulation 56 and develop crops with enhanced nutritional quality. Here we demonstrated that 57 alteration of a single amino acid in wild type OR greatly enhanced its ability to 58 promote carotenoid accumulation. While overexpression of OR from Arabidopsis 59 ( AtOR ) or from an agronomically important crop sorghum ( SbOR ) increased 60 carotenoid levels up to two-fold, expression of AtOR His (R90H) or SbOR His (R104H) 61 variants dramatically enhanced carotenoid accumulation by up to seven-fold in the 62 Arabidopsis calli. Moreover, we found that AtOR Ala (R90A) functioned similarly as 63 AtOR His to promote carotenoid overproduction. Neither AtOR nor AtOR His greatly 64 affected carotenogenic gene expression. AtOR His exhibited similar interactions with 65 phytoene synthase (PSY) as AtOR in post-transcriptionally regulating PSY protein 66 abundance, but was not accompanied/linked with enhanced PSY activity. AtOR His 67 triggered biogenesis of membranous chromoplasts in the Arabidopsis calli, which 68 shared similar structures as chromoplasts found in curd of orange cauliflower mutant. 69 By contrast, AtOR did not cause plastid type change in comparison with wild type, 70 but produced plastids containing larger electron dense plastoglobuli. The unique 71 ability of AtOR His in mediating chromoplast biogenesis is responsible for its enhanced 72 carotenoid overproduction. Our study demonstrates OR His/Ala as powerful tools for 73 carotenoid enrichment in plants, and provides insights into the mechanisms 74 underlying OR His regulated carotenoid accumulation.