Miracle-dz/UniFAR-FTUs huggingface dataset:
Recruitment and Activation of Phospholipase Cγ1 by Vascular Endothelial Growth Factor Receptor-2 Are Required for Tubulogenesis and Differentiation of Endothelial Cells*

Vascular endothelial growth factor-mediated angiogenic signal transduction relay is achieved by coordinated induction of endothelial cell proliferation, migration, and differentiation. These complex cellular processes are most likely controlled by activation of both cooperative and antagonistic signals by vascular endothelial growth factor receptors (VEGFRs). Here, we investigated the contribution of tyrosine-phosphorylated residues of VEGFR-2/fetal liver kinase-1 to endothelial cell proliferation and differentiation and activation of signaling proteins. Mutation of tyrosine 1006 of VEGFR-2 to phenylalanine severely impaired the ability of this receptor to stimulate endothelial cell differentiation and tubulogenesis. Paradoxically, the mutant receptor stimulated endothelial cell proliferation far better than the wild-type receptor. Further analysis showed that tyrosine 1006 is responsible for phospholipase Cγ1 (PLCγ1) activation and intracellular calcium release in endothelial cells. Activation of PLCγ1 was selectively mediated by tyrosine 1006. Mutation of tyrosines 799, 820, 949, 994, 1080, 1173, and 1221 had no measurable effect on the ability of VEGFR-2 to stimulate PLCγ1 activation. Association of VEGFR-2 with PLCγ1 was mainly established between tyrosine 1006 and the C-terminal SH2 domain of PLCγ1 in vitro and in vivo. Taken together, the results indicate that phosphorylation of tyrosine 1006 is essential for VEGFR-2-mediated PLCγ1 activation, calcium flux, and cell differentiation. More importantly, VEGFR-2-mediated endothelial cell proliferation is inversely correlated with the ability of VEGFR-2 to associate with and activate PLCγ1.
The financial literacy of students and investment decisions in the Indonesia stock exchange

This study aims to analyze how the role of student financial literacy is in influencing the investment decision in the Indonesia Stock Exchange. The populations are the students of Economic and Business Faculty in University of Muhammadiyah Sumatera Utara. This is an explanatory research using descriptive analysis and causality test with SPSS tool. The samples of this research are 198 students who had ever got series of subjects related to financial management, investment and capital market. The results have shown that there are differences in the level of financial literacy in students. The results of this study also indicate that the financial literacy of students do not significantly influence their investment decision in the Indonesia Stock Exchange. The high level of financial literacy on the students is not the only factor in investment decision making. There are other factors that also influence the student investment decision making when investing in The Indonesia Stock Exchange.
Anti‐FGF‐23 neutralizing antibodies ameliorate muscle weakness and decreased spontaneous movement of Hyp mice

Fibroblast growth factor 23 (FGF‐23) plays causative roles in the development of several hypophosphatemic rickets/osteomalacia such as X‐linked hypophosphatemic rickets/osteomalacia (XLH) and tumor‐induced rickets/osteomalacia. Patients with hypophosphatemic rickets/osteomalacia often complain of muscle weakness and bone pain that severely affect daily activities of these patients. The purpose of this study was to examine whether anti‐FGF‐23 antibodies, which have been shown to improve hypophosphatemia and rachitic changes of juvenile Hyp mice in a murine model of XLH, also ameliorate hypophosphatemic osteomalacia and affect muscle force and spontaneous motor activity in adult Hyp mice. Repeated injections of anti‐FGF‐23 antibodies increased serum phosphate and 1,25‐dihydroxyvitmain D levels and enhanced mineralization of osteoid in adult Hyp mice, whereas bone length did not change. We found that grip strength was weaker and that spontaneous movement was less in adult Hyp mice than in wild‐type mice. In addition, FGF‐23 antibodies increased grip strength and spontaneous movement. These results suggest that the inhibition of excess FGF‐23 action not only ameliorates hypophosphatemia and impaired mineralization of bone but also improves muscle weakness and daily activities of patients with FGF‐23‐related hypophosphatemic rickets/osteomalacia. © 2011 American Society for Bone and Mineral Research.
Penerapan Kesehatan Keselamatan Kerja (K3) di UMKM Laundry Balikpapan

Usaha laundry merupakan suatu usaha yang saat ini mulai berkembang di Balikpapan. Laundry menjadi kebutuhan bagi warga Balikpapan yang memiliki jadwal padat sehingga tidak punya waktu lebih untuk mencuci. Komunitas Laundry Balikpapan (KLB) merupakan suatu komunitas yang didirikan untuk menjadi wadah bagi pengusaha-pengusaha laundry di Balikpapan. Salah satu permasalahan yang ditemui di KLB adalah kurangnya pemahaman tentang pentingnya memperhatikan keselamatan, keamanan kerja (K3) dalam melaksanakan pekerjaan sehari-hari. Pelaksanaan pelatihan meliputi pemberian materi, pengisian kuesioner pre dan post test, serta praktek langsung pelaksanaan K3 di Laundry di Hotel Novotel Balikapan. Peserta berjumlah 22 orang yang merupakan pekerja dan pemilik usaha laundry yang tergabung dalam KLB. Berdasarkan pre-post tes yang diberikan, pengetahuan peserta meningkat dan setelah melaksanakan pelatihan K3 di Unit Laundry Novotel Balikpapan, peserta semakin paham mengenai pelaksanan K3 di tempat usaha mereka masing-masing. Kesimpulan yang diperoleh dari kegiatan ini adalah bahwa setiap pemilik maupun pekerja di tempat usaha laundry harus memahami standar K3 yang harus disediakan di tempat kerja guna menjamin kesehatan dan keselamatan kerja setiap orang yang ada di wilayah tersebut.
What are the key determinants of mobile banking Adoption in Pakistan

This study was focused to factors of social influence, ubiquitous financial service, perceived trust, relative advantage, Perceived Risk, personal Innovativeness, and Perceived Cost with respect to mobile banking adoption in Pakistan. Technology adoption model (TAM) model is used along with some other determinants. Data collected from 446 respondents from a structured questionnaire from Lahore, Islamabad and Karachi. Snowball sampling technique is use because population was unknown. Only ubiquitous financial service was not significant variable other variables found significant. Paper having implication for mobile banking service providers and consumer too.
Associations of MHC Class II Alleles in Norwegian Primary Sjögren's Syndrome Patients: Implications for Development of Autoantibodies to the Ro52 Autoantigen

Sjögren's syndrome (SS) is a chronic autoimmune disease characterized by dryness of the eyes and mouth. Currently, the highly polymorphic major histocompatibility complex (MHC) genes are the best documented genetic risk factor for the development of autoimmune disease. We examined the MHC class II alleles DRB1, DRB3, DRB4, DRB5, DQA1 and DQB1 in a group of Norwegian pSS patients and compared with a group of healthy controls. Because a number of studies have shown that some of the MHC class II alleles are not associated with the disease as a whole, but rather to the development of autoantibodies, anti‐Ro52 autoantibodies in serum were measured and compared to MHC class II allele status. A clear association with pSS was detected for the DRB1*0301 and DRB3*0101 alleles, but these alleles were more closely associated with the presence of anti‐Ro52 autoantibodies than with pSS itself. Moreover, the DQA1*0501 and DQB1*0201 alleles were only associated with the presence of anti‐Ro52 autoantibodies. This study shows that the production of anti‐Ro52 autoantibodies in pSS is associated with the DRB1*0301, DRB3*0101, DQA1*0501 and DQB1*0201 alleles which are in strong linkage disequilibrium.
Stochastic-rheological Simulation of Free-fall Arm Impact in Children: Application to Playground Injuries

The aim of this study was to develop and pilot a stochastic-rheological biomechanical model to investigate the mechanics of impact fractures in the upper limbs of children who fall in everyday situations, such as when playing on playground equipment. The rheological aspect of the model characterises musculo-skeletal tissues in terms of inertial, elastic and viscous parameters. The stochastic aspect of the model allows natural variation of children's musculo-skeletal mechanical properties to be accounted for in the analysis. The relationship of risk factors, such as fall height, impact surface, child mass and bone density, to the probability of sustaining an injury in playground equipment falls were examined and found to closely match findings in epidemiological, clinical and biomechanical literature. These results suggest that the stochastic-rheological model is a useful tool for the evaluation of arm fracture risk in children. Once fully developed, information from this model will provide the basis for recommendations for modifications to playground equipment and surface standards.
Abnormal development of the hippocampal dentate gyrus in mice lacking the CXCR4 chemokine receptor

We investigated the role of the CXCR4 chemokine receptor in development of the mouse hippocampus. CXCR4 mRNA is expressed at sites of neuronal and progenitor cell migration in the hippocampus at late embryonic and early postnatal ages. mRNA for stromal cell-derived factor 1 (SDF-1), the only known ligand for the CXCR4 receptor, is expressed close to these migration sites, in the meninges investing the hippocampal primordium and the primordium itself. In mice engineered to lack the CXCR4 receptor, the morphology of the hippocampal dentate gyrus (DG) is dramatically altered. Gene expression markers for DG granule neurons and bromodeoxyuridine labeling of dividing cells revealed an underlying defect in the stream of postmitotic cells and secondary dentate progenitor cells that migrate toward and form the DG. In the absence of CXCR4, the number of dividing cells in the migratory stream and in the DG itself is reduced, and neurons appear to differentiate prematurely before reaching their target. Our findings indicate a role for the SDF-1/CXCR4 chemokine signaling system in DG morphogenesis. Finally, the DG is unusual as a site of adult neurogenesis. We find that both CXCR4 and SDF-1 are expressed in the adult DG, suggesting an ongoing role in DG morphogenesis.
Cardiac Intensive Care

Pediatric Critical Care Medicine www.pccmjournal. org 529 Objective: To empirically derive the optimal measure of pharmacologic cardiovascular support in infants undergoing cardiac surgery with bypass and to assess the association between this score and clinical outcomes in a multi-institutional cohort. Design: Prospective, multi-institutional cohort study. Setting: Cardiac ICUs at four academic children’s hospitals participating in the Pediatric Cardiac Critical Care Consortium during the study period. Patients: Children younger than 1 year at the time of surgery treated postoperatively in the cardiac ICU. Interventions: None. Measurements and Main Results: Three hundred ninety-one infants undergoing surgery with bypass were enrolled consecutively from November 2011 to April 2012. Hourly doses of all vasoactive agents were recorded for the first 48 hours after cardiac ICU admission. Multiple derivations of an inotropic score were tested, and maximum vasoactive-inotropic score in the first 24 hours was further analyzed for association with clinical outcomes. The primary composite “poor outcome” variable included at least one of mortality, mechanical circulatory support, cardiac arrest, renal replacement therapy, or neurologic injury. High vasoactive-inotropic score was empirically defined as more than or equal to 20. Multivariable logistic regression was performed controlling for center and patient characteristics. Patients with high vasoactive-inotropic score had significantly greater odds of a poor outcome (odds ratio, 6.5; 95% CI, 2.9–14.6), mortality (odds ratio, 13.2; 95% CI, 3.7–47.6), and prolonged time to first extubation and cardiac ICU length of stay compared with patients with low vasoactive-inotropic score. Stratified analyses by age (neonate vs infant) and surgical complexity (low vs high) showed similar associations with increased morbidity and mortality for patients with high vasoactive-inotropic score. Conclusions: Maximum vasoactive-inotropic score calculated in the first 24 hours after cardiac ICU admission was strongly and significantly associated with morbidity and mortality in this multi-institutional cohort of infants undergoing cardiac surgery. Maximum vasoactive-inotropic score more than or equal to 20 predicts an increased likelihood of a poor composite clinical outcome. The findings were consistent in stratified analyses by age and surgical complexity. (Pediatr Crit Care Med 2014; 15:529–537)
Organizational Innovation and Performance on Embroidery and Needlepoint SME’s in West Sumatera

: Innovation plays an important role in developing the economy, to expand and sustain the high performance of firms, to maintain a competitive edge in the industry and improved the standard living and in creating a better quality of life. The purpose of this study is to identify the effects of organizational culture and learning orientation to organizational innovation and performance. The research method was quantitative analysis using SmartPLS and conducted with purposive sampling technique on embroidery and needlepoint SME owners in West Sumatera. Embroidery and needlepoint craft are the original products of West Sumatera, which is already well-known not only in the country but also it has reached to abroad. Fifty-three respondents involved in this study were located in Bukittinggi, Agam, Payakumbuh and Lima Puluh Kota. The findings showed that organizational culture and learning orientation have significant effect on organizational innovation; organizational culture and learning orientation have significant effect to organizational performance. Although the previous study showed there is a significant effect of organizational innovation to organizational performance, but in this study was not accepted.
The Influence of Corporate Governance on Corporate Social Responsibility Disclosure: A Focus on Accountability

The purpose of this study is to examine the extent of the accountability-related to CSRD and the influence of the corporate governance on CSRD practices. This study used the Modified Koppell’s Model in understanding the accountability-related to CSRD, which consists of four dimensions, namely; transparency, liability, responsibility and responsiveness. The corporate governance characteristics studied are board size, board independence, board meetings, and female directors on board, which are used as the predictors of company’s accountability on CSRD. Annual reports of 100 public listed companies in Malaysia were analysed using the content analysis of two years observations i.e. 2015 and 2016. Descriptive analyses were conducted and it has been discovered that the percentages of accountability-related CSRD amongst Malaysian companies are mostly low. The study also provides empirical evidence that only board size has a significant relationship with the accountability-related CSRD. In general, this study put forward some insights about Malaysian CSRD practices from the perspective of accountability as well as governance related strategy in enhancing companies’ accountability in reporting CSR information. The study also signifies the need to strategically establish a relevant CSRD-accountability model towards an enhanced ethical-accountability based reporting.
Impact of Water Activity, Temperature, and Physical State on the Storage Stability of Lactobacillus paracasei ssp. paracasei Freeze‐Dried in a Lactose Matrix

The aim of this study was to determine whether the combined effect of water activity and temperature on inactivation rates of freeze‐dried microorganisms in a lactose matrix could be explained in terms of the glass transition theory. The stabilized glass transition temperature, Tg, of the freeze‐dried products was determined by differential scanning calorimetry at two different temperatures, T (20 and 37 °C), and different water activities (0.07–0.48). This information served as a basis for defining conditions of T and water activity, which led to storage of the bacteria in the glassy (T< Tg) and nonglassy (T> Tg) states. The rates of inactivation of the dry microorganisms subjected to different storage conditions were determined by plate counts and could be described by first‐order kinetics. Rates were analyzed as a function of water activity, storage temperature, and the difference between Tg and T. Inactivation below Tg was low; however, Tg could not be regarded as an absolute threshold of bacteria stability during storage. When the cells were stored in the nonglassy state (T> Tg), inactivation proceeded faster, however, not as rapid as suggested by the temperature dependence of the viscosity above the glass transition temperature. Furthermore, the first‐order rate constant, k, was dependent on the storage temperature per se rather than on the temperature difference between the glass transition temperature and the storage temperature (T – Tg).
Happy Face Superiority Effect in Change Detection Paradigm

The aim of the present study was to investigate which affective component guides cognitive processing of emotional facial expressions. According to the threat hypothesis, processing of angry faces is prioritized by the human cognitive system, because rapid detection of threat has a large adaptive value. The negativity hypothesis presumes that distressing emotional experiences of other people attract attention, regardless of whether they represent danger or not. The emotionality hypothesis proposes that positive emotional facial expressions can capture attention as effective as negative ones, while the happy face superiority hypothesis predicts that happy faces are prioritized. In the present study, which was conducted on 24 participants, change detection paradigm was used, because that procedure enables insight into the later stage of information processing. The results obtained show that happy facial expressions are heavily prioritized by the human cognitive system. In explanation of these results, that clearly support the happy face superiority hypothesis, we propose that angry expressions are initially prioritized by our cognitive system, because we benefit from early detection of potential threat in the environment, but in later cognitive processing, happy expressions are given the priority, because smiling is a valuable mechanism for forming and maintaining cooperative relationships. Besides the theoretical relevance, the present study is also valuable methodologically, because we demonstrated that change detection paradigm can be efficiently used for the research of emotional facial expressions processing.
Determinants Of Islamic Banks’ Margins In Asian Countries

This paper examines the determinants of margins in Islamic banks for the period 2005‐2013. Specifically, we apply pooled, static and dynamic panel regressions on 76 Islamic banks in Asian countries. The results suggest the main factors that influence the margins of Islamic banks are numerous including bank size, default risk, overhead cost, capitalization, market concentration, GDP growth and inflation. It is evident that enhancing macroeconomic policies, risk management capabilities and operational efficiency could help in lowering the margins.
Recipient ability of bacteriophage-resistant mutants of Escherichia coli K-12

The ability of a wide range of bacteriophage-resistant mutants to act as recipients in conjugation with F'lac pro and R100-1 donors has been studied. A number of mutant types defective in recipient ability with F'lac pro, as well as mutants which were hyperrecptive with R100-1, have been detected.
Apoptosis induced in neuronal cells by C-terminal amyloid beta-fragments is correlated with their aggregation properties in phospholipid membranes.

A number of findings suggest that lipophilic monomeric Abeta peptides can interact with the cellular lipid membranes. These interactions can affect the membrane integrity and result in the initiation of apoptotic cell death. The secondary structure of C-terminal Abeta peptides (29-40) and the longer (29-42) variant have been investigated in solution by circular dichroism measurements. The secondary structure of lipid bound Abeta (29-40) and (29-42) peptides prepared at different lipid/peptide ratio's, was investigated by ATR-FTIR spectroscopy. Finally, the changes in secondary structure (i.e. the transition of alpha-helix to beta-sheet) of the lipid bound peptides were correlated with the induction of neurotoxic and apoptotic effects in neuronal cells. The data suggest that the C-terminal fragments of the Abeta peptide induce a significant apoptotic cell death, as demonstrated by caspase-3 measurements and DNA laddering, with consistently a stronger effect of the longer Abeta (29-42) variant. Moreover, the induction of apoptotic death induced by these peptides can be correlated with the secondary structure of the lipid bound amyloid beta peptides. Based on these observations, it is proposed that membrane bound aggregated Abeta peptides (produced locally as the result of gamma-secretase cleavage) can accumulate and aggregate in the membrane. These membrane bound beta-sheet aggregated amyloid peptides induce neuronal apoptotic cell death.
Musculoskeletal disorders and ergonomic hazards among Iranian physicians.

BACKGROUND The aim of this study was to determine the prevalence of musculoskeletal disorders (MSDs) and ergonomic hazards and their relationship among Iranian physicians who work in teaching hospitals. METHODS A self-administered questionnaire was provided to 405 physicians in four teaching hospitals. The questionnaire had three major parts: the first part gathered individual and work-related data, the second was a modified version of the Standardized Nordic questionnaire for musculoskeletal symptoms, and the last part evaluated the duration of exposure to ergonomic hazards at work. RESULTS Knee pain (19.8%) was the most common complaint among physicians, followed by low back (15.1%) and neck pain (9.8%). A total of 169 physicians (41.7%) reported symptoms in at least one part of their bodies. Prolonged sitting, standing, and neck flexion were the most common reported ergonomic hazards among participants. Multiple logistic regression analysis reported statistically significant associations for the outcomes of knee pain and symptoms in any part of the body with the work-related factors of years of employment and work hours per shift. CONCLUSION The prevalence of musculoskeletal complaints among physicians was low, less than other health care workers, but similar to those reported in the general population. These musculoskeletal complaints were, however, associated with traditional work-related and ergonomic factors.
Energy Efficient Sleep Strategy for Decoupled Uplink#x002F;Downlink Access in HetNets

In dense and heterogeneous networks, the decoupled uplink#x002F;downlink (UL#x002F;DL) access (DUDA) design has drawn great attentions for improving system performance. Energy efficiency (EE) becomes a major concern for densely deployed heterogeneous cellular networks (HetNets). In this paper, we theoretically analyze the energy efficient sleep strategy for DUDA HetNets. Through using stochastic geometry theory, we first examine the applicability of conventional sleep strategy to DUDA networks and design a new DUDA sleep strategy. We then formulate the energy consumption minimization problem and EE optimization problem, and derive the optimal BS sleep probability. Numerical results reveal that conventional sleep strategy may provide inaccurate guidance for sleep design in DUDA networks, which may lead to excessive sleeps and decrease system EE. Meanwhile our DUDA sleep strategy can effectively reduce network energy consumption. We also find that the dense deployment of small cells may generally increase network EE, but this improvement saturates as the BS density further increases.