Miracle-dz/UniFAR-FTUs huggingface dataset:
Further contributions to the Coleoptera fauna of New Brunswick with an addition to the fauna of Nova Scotia, Canada

Abstract This paper treats 134 new records of Coleoptera for the province of New Brunswick, Canada from the following 41 families: Gyrinidae, Carabidae, Dytiscidae, Histeridae, Leiodidae, Scarabaeidae, Scirtidae, Buprestidae, Elmidae, Limnichidae, Heteroceridae, Ptilodactylidae, Eucnemidae, Throscidae, Elateridae, Lampyridae, Cantharidae, Dermestidae, Bostrichidae, Ptinidae, Cleridae, Melyridae, Monotomidae, Cryptophagidae, Silvanidae, Laemophloeidae, Nitidulidae, Endomychidae, Coccinellidae, Corylophidae, Latridiidae, Tetratomidae, Melandryidae, Mordellidae, Tenebrionidae, Mycteridae, Pyrochroidae, Aderidae, Scraptiidae, Megalopodidae, and Chrysomelidae. Among these, the following four species are newly recorded from Canada: Dirrhagofarsus ernae Otto, Muona & McClarin (Eucnemidae), Athous equestris (LeConte) (Elateridae), Ernobius opicus Fall (Ptinidae), and Stelidota coenosa Erichson (Nitidulidae). The Family Limnichidae is newly reported for New Brunswick, and one species is added to the fauna of Nova Scotia. Stephostethus productus Rosenhauer (Latridiidae), Tetratoma (Abstrulia) variegata Casey (Tetratomidae), and Chauliognathus marginatus (Fabricius) (Cantharidae) are removed from the faunal list of New Brunswick, and additional records of Lacconotus punctatus LeConte (Mycteridae) are presented and discussed. Lindgren funnel traps provided specimens for 104 (78%) of the species and were the sole source of specimens for 89 (66%) of the species reported here, suggesting they are a very useful tool for sampling Coleoptera fauna in the forests of New Brunswick.
Predominance of rhinovirus in the nose of symptomatic and asymptomatic infants

Respiratory infections in infancy may protect against developing Th2‐mediated allergic disease (hygiene hypothesis). To estimate the relative contribution of particular viruses to the development of the immune system and allergic disease, we investigated longitudinally the prevalence of respiratory viral infections in infants. One hundred and twenty‐six healthy infants were included in this prospective birth cohort study in their first year of life. Physical examination was performed and nasal brush samples were taken during routine visits every 6 months and during an upper respiratory tract infection (URTI) (sick visits). The prevalence of respiratory viral infections in infants with URTI, infants with rhinitis without general malaise and infants without nasal symptoms was studied. Rhinovirus was the most prevalent pathogen during URTI and rhinitis in 0‐ to 2‐year‐old infants (∼40%). During URTI, also respiratory syncytial virus (∼20%) and coronavirus (∼10%) infections were found, which were rarely detected in infants with rhinitis. Surprisingly, in 20% of infants who did not present with nasal symptoms, rhinovirus infections were also detected. During routine visits at 12 months, a higher prevalence of rhinovirus infections was found in infants who attended day‐care compared with those who did not. We did not observe a relation between breast‐feeding or smoking by one or both parents and the prevalence of rhinovirus infections. The parental history of atopy was not related to the prevalence of rhinovirus infection, indicating that the genetic risk of allergic disease does not seem to increase the chance of rhinovirus infections. In conclusion, rhinovirus infection is the most prevalent respiratory viral infection in infants. It may therefore affect the maturation of the immune system and the development of allergic disease considerably.
Ribonuclease activity and RNA binding of recombinant human Dicer

RNA silencing phenomena, known as post‐transcriptional gene silencing in plants, quelling in fungi, and RNA interference (RNAi) in animals, are mediated by double‐stranded RNA (dsRNA) and mechanistically intersect at the ribonuclease Dicer. Here, we report cloning and expression of the 218 kDa human Dicer, and characterization of its ribonuclease activity and dsRNA‐binding properties. The recombinant enzyme generated ∼21–23 nucleotide products from dsRNA. Processing of the microRNA let‐7 precursor by Dicer produced an apparently mature let‐7 RNA. Mg2+ was required for dsRNase activity, but not for dsRNA binding, thereby uncoupling these reaction steps. ATP was dispensable for dsRNase activity in vitro. The Dicer·dsRNA complex formed at high KCl concentrations was catalytically inactive, suggesting that ionic interactions are involved in dsRNA cleavage. The putative dsRNA‐binding domain located at the C‐terminus of Dicer was demonstrated to bind dsRNA in vitro. Human Dicer expressed in mammalian cells colocalized with calreticulin, a resident protein of the endoplasmic reticulum. Availability of the recombinant Dicer protein will help improve our understanding of RNA silencing and other Dicer‐related processes.
Manic spectrum symptoms are correlated to the severity of pain and the health-related quality of life in patients with fibromyalgia.

OBJECTIVES We aimed at investigating the impact of lifetime manic spectrum symptoms on the severity of pain and the health-related quality of life (HRQoL) in patients with fibromyalgia (FM). METHODS One hundred and sixty-seven patients with FM, assessed according to the ACR criteria, were consecutively enrolled. Psychiatric diagnoses were carried out following the Diagnostic and Statistical Manual for Mental Disorders (DSM-IV-TR). The severity of pain and the HRQoL of FM patients was measured by means of the Fibromyalgia Impact Questionnaire (FIQ) and the Medical Outcomes Study Short Form-36 Health Survey (MOS SF-36); the mood spectrum symptomatology by means of the Mood Spectrum-Self Report (MOODS-SR). RESULTS A high rate of lifetime manic symptoms was detected and resulted as related to the Pain Visual Analogic Scale ("pain VAS") of the FIQ and the FIQ total scores as well as to the "bodily pain", and to the physical and mental component summary scores of the MOS SF-36, both in the whole sample (n=167) and in FM patients without bipolar disorder (n=160). CONCLUSION Our results highlight the need to pay more attention to manic spectrum symptoms and features in FM patients, because of their relationship with the severity of pain and with a worse HRQoL.
Articular cartilage cells immortalized by a temperature sensitive mutant of SV40 large T antigen survive and form cartilage tissue in articular cartilage environment

A chondrogenic cell line, TC6, was established by using cells derived from articular cartilage of transgenic mice harboring a temperature‐sensitive mutant simian virus (SV) 40 large T‐antigen gene. TC6 cells express genes encoding proteins related to cartilage phenotypes such as type II collagen. To examine the in vivo behavior of the TC6 cells, these cells were implanted into cavity‐shaped full‐thickness defects made in the articular cartilage of the central part of the patellar grooves of mouse femora. One week after implantation, the morphology of the cells was still fibroblastic but these cells were just about to start to form a cartilage‐like matrix. By 6 weeks after implantation, the cells had produced abundant cartilaginous matrix and their morphology became closer to that of authentic chondrocytes. This was in sharp contrast to the fibroblastic morphology of these cells in an in vitro environment even after long‐term culture. These observations indicate that a cartilage‐matrix environment provides a scaffold for the TC6 cells to form cartilage tissues. Our data show that the genetically engineered chondrocytic cell line, TC6, can form a cartilage‐like matrix in vivo. J. Cell. Biochem. 75:338–345, 1999. © 1999 Wiley‐Liss, Inc.
Autism Classification Using Brain Functional Connectivity Dynamics and Machine Learning

The goal of the present study is to identify autism using machine learning techniques and resting-state brain imaging data, leveraging the temporal variability of the functional connections (FC) as the only information. We estimated and compared the FC variability across brain regions between typical, healthy subjects and autistic population by analyzing brain imaging data from a world-wide multi-site database known as ABIDE (Autism Brain Imaging Data Exchange). Our analysis revealed that patients diagnosed with autism spectrum disorder (ASD) show increased FC variability in several brain regions that are associated with low FC variability in the typical brain. We then used the enhanced FC variability of brain regions as features for training machine learning models for ASD classification and achieved 65% accuracy in identification of ASD versus control subjects within the dataset. We also used node strength estimated from number of functional connections per node averaged over the whole scan as features for ASD classification.The results reveal that the dynamic FC measures outperform or are comparable with the static FC measures in predicting ASD.
Region‐ and stage‐specific effects of FGFs and BMPs in chick mandibular morphogenesis

The mandibular processes are specified as at least two independent functional regions: two large lateral regions where morphogenesis is dependent on fibroblast growth factor (FGF)‐8 signaling, and a small medial region where morphogenesis is independent of FGF‐8 signaling. To gain insight into signaling pathways that may be involved in morphogenesis of the medial region, we have examined the roles of pathways regulated by FGFs and bone morphogenetic proteins (BMPs) in morphogenesis of the medial and lateral regions of the developing chick mandible. Our results show that, unlike in the lateral region, the proliferation and growth of the mesenchyme in the medial region is dependent on signals derived from the overlying epithelium. We also show that medial and lateral mandibular mesenchyme respond differently to exogenous FGFs and BMPs. FGF‐2 and FGF‐4 can mimic many of the effects of mandibular epithelium from the medial region, including supporting the expression of Msx genes, outgrowth of the mandibular processes and elongation of Meckel's cartilage. On the other hand, laterally placed FGF beads did not induce ectopic expression of Msx genes and did not affect the growth of the mandibular processes. These functional studies, together with our tissue distribution studies, suggest that FGF‐mediated signaling (other than FGF‐8), through interactions with FGF receptor‐2 and downstream target genes including Msx genes, is part of the signaling pathway that mediates the growth‐promoting interactions in the medial region of the developing mandible. Our observations also suggest that BMPs play multiple stage‐ and region‐specific roles in mandibular morphogenesis. In this study, we show that exogenous BMP‐7 applied to the lateral region at early stages of development (stage 20) caused apoptosis, ectopic expression of Msx genes, and inhibited outgrowth of the mandibular processes and the formation of Meckel's cartilage. Our additional experiments suggest that the differences between the effects of BMP‐7 on lateral mandibular mesenchyme at stage 20 and previously reported results at stage 23 (Wang et al., [1999] Dev. Dyn. 216:320–335) are related to differences in stages of differentiation in that BMP‐7 promotes apoptosis in undifferentiated lateral mandibular mesenchyme, whereas it promotes chondrogenesis at later stages of development. We also showed that, unlike mandibular epithelium and medially placed FGF beads, medially placed BMP‐7 did not support outgrowth of the isolated mesenchyme and at stage 20 induced the formation of a duplicated rod of cartilage extending from the body of Meckel's cartilage. These observations suggest that BMPs do not play essential roles in growth‐promoting interactions in the medial region of the developing mandible. However, BMP‐mediated signaling is a part of the signaling pathways regulating chondrogenesis of the mandibular mesenchyme. © 2002 Wiley‐Liss, Inc.
Cross-Measure Equivalence and Communicability in the Assessment of Depression

All measures of depression yield a global summary scale indicating the severity of depressive symptoms, implicitly conceptualized as a homogeneous construct. However, depression is a heterogeneous construct, with different presentations, subtypes, correlates, and responses to interventions. In response, the National Institute of Mental Health (NIMH) has suggested changes in the way depression is assessed, moving the focus to specific factors, such as cognitive, somatic, or affective symptoms. Still, there is little factor overlap between measures, and shared factors are weighted differently. To help fulfill NIMH’s strategic plan, this study used canonical correlation analysis (CCA) to explore shared latent variables and redundancy across the measures. It also analyzed the psychometric properties of factor-based subscales in the Beck Depression Inventory–2nd edition (BDI-II), Center for Epidemiologic Studies Depression scale (CES-D), Inventory for Depression and Anxiety Symptoms (IDAS), and Inventory of Depressive Symptomatology (IDS). Using a diverse sample of 218 students who reported at least mild depressive symptoms, this study found that the IDAS was best aligned with NIMH’s strategic plan; it has complete DSM-IV/DSM-5 symptom coverage and content-valid, psychometrically sound subscales. The BDI-II, CES-D, and IDS did not have consistent subscales, nor had incomplete or incongruent coverage of DSM criteria. Furthermore, CCA revealed low redundancy across measures (23% to 41% shared variance). These results suggest that different measures of depression do not measure the same construct. As a partial solution, empirical conversion tables were provided for researchers and clinicians to empirically compare total scores from different measures.
Effects of blood pressure levels on case fatality after acute stroke

Objective We evaluated the relationship between admission blood pressure (BP) and early prognosis in patients with acute stroke in a single cohort. Design The subjects comprised 1004 cases of brain infarction and 1097 cases of brain hemorrhage, who were admitted to hospitals on the day of stroke onset. Death within 30 days after onset was evaluated in relation to admission BP levels. Results In brain infarction, a U-shaped relationship was found between BP levels and mortality rate, with a nadir at systolic blood pressure (SBP) of 150–169 mmHg and at diastolic blood pressure (DBP) of 100–110 mmHg. After adjustments for age and sex, the highest relative risks (RR) was observed in the lowest BP levels compared with nadir groups, and were 2.69 [95% confidence interval (CI), 1.43–5.07] in SBP and 3.49 (95% CI, 1.58–7.74) in DBP. In subjects with previous hypertension, the relationship between prognosis and SBP level shifted significantly toward higher pressure by about 10 mmHg compared with those without previous hypertension. In subjects with brain hemorrhage, the relationship between BP levels and mortality rate showed a J-shape in SBP and a U-shape in DBP. Highest BP levels had the poorest prognoses (≥ 230 mmHg in SBP, RR = 4.13, 95% CI = 2.45–6.94; ≥ 120 mmHg in DBP, RR = 1.83, 95% CI = 1.11–3.04). Conclusion Lower and higher BP after brain infarction and higher BP after brain hemorrhage were predictors for poor early prognosis. In subjects with brain infarction, patients with previous hypertension had better outcomes at higher admission BP level than did normotensive patients.
Dendritic cell neoplasms: An overview

Dendritic cell neoplasms are rare tumors that are being recognized with increasing frequency. They were previously classified as lymphomas, sarcomas, or histiocytic neoplasms. The World Health Organization (WHO) classifies dendritic cell neoplasms into five groups: Langerhans' cell histiocytosis, Langerhans' cell sarcoma, Interdigitating dendritic cell sarcoma/tumor, Follicular dendritic cell sarcoma/tumor, and Dendritic cell sarcoma, not specified otherwise (Jaffe, World Health Organization classification of tumors 2001; 273–289). Recently, Pileri et al. provided a comprehensive immunohistochemical classification of histiocytic and dendritic cell tumors (Pileri et al., Histopathology 2002;59:161–167). In this article, a concise overview regarding the pathological, clinical, and therapeutic aspects of follicular dendritic, interdigitating dendritic, and Langerhans' cell tumors is presented. Am. J. Hematol. 82:924–928, 2007. © 2007 Wiley‐Liss, Inc.
Association between Psychiatric Illness and Social Support, Cognitive Functioning, Treatment Adherence and Functional ability in Chronic Kidney Disease Patients

Introduction: Chronic Kidney Disease (CKD) is emerging as an important chronic disease globally. In India, it is estimated that prevalence of CKD is around 15 -20%. Patients with CKD are prone to develop psychiatric illness like depression, anxiety, insomnia and even psychosis. Multiple factors contribute to the risk of psychiatric morbidity in CKD. Psychiatric morbidity in CKD is associated with poor adherence and outcome. Study aimed to determine the association of psychiatric morbidity in CKD with factors like social support, functional ability, cognitive functioning and its impact on treatment adherence in chronic kidney disease. Material and methods: Cross sectional study, conducted in department of nephrology, Kilpauk Medical College for 6 months from February 2017 to August 2017. Consenting patients in the age group of 18 – 60 years, diagnosed to have CKD by consultant nephrologist and on various treatment modalities (conservative treatment, hemodialysis, renal transplantation) were included in this study. Patients diagnosed to have mental illness prior to the onset of CKD were excluded. Results: A total of 110 patients consented to participate in the study. Of these, 36.4% (n=40) were in conservative treatment, 31.8% (n= 35) were in hemodialysis, 31.8% (n=35) were post renal transplant patients. Conclusion: Treatment adherence, social support system and functional ability were better for patients on post renal transplantation than either conservative treatment or hemodialysis.
An outcomes evaluation of an Australian Hospital in the Nursing Home admission avoidance programme.

AIMS AND OBJECTIVES To undertake an outcomes evaluation of a Hospital in the Nursing Home (HINH) admission avoidance programme. BACKGROUND Admission avoidance type services such as Hospital in the Home have a place in improving service delivery for certain population groups. Research related to HINH has been limited, derived from various different health care systems internationally and results are varied. DESIGN A quasi-experimental study was conducted at one regional hospital. Routinely collected health information system data from two separate data sources were linked to undertake analysis. METHODS Those in the intervention group were matched to a comparison group of patients on the basis of three characteristics (age, gender and diagnostic category). Other factors that could affect a patient's hospital outcomes and length of stay (LOS) were statistically controlled for. Participants were aged care facility residents enrolled in a HINH programme (n = 62) and a matched group receiving usual in-hospital care (n = 115). Emergency department (ED) outcome measures included LOS and re-presentation. Hospital admission-related outcome measures included episode of care LOS, in-hospital LOS and hospital readmission. RESULTS A significant independent relationship between HINH programme enrolment and shorter in-hospital LOS was identified even after adjusting for other characteristics OR 0·16 (95% CI 0·28, 0·99 p < 0·001). CONCLUSION The HINH model evaluated, with its focus on delivering acute care for aged care facility residents, can impact on health service delivery. RELEVANCE TO CLINICAL PRACTICE With a demonstrated reduction in in-hospital LOS, the available bed space created can be used for other patients perhaps waiting in the ED or waiting for surgery.
Improving the Indoor Localization Accuracy for CPS by Reorganizing the Fingerprint Signatures

This paper firstly represents a survey of recent researches on localization of CPS and analyzes the advantages and limitations of the existing schemes. To overcome the limitations, a novel localization scheme is then proposed, which includes site survey, received signal comparison, and location correction phases. The main improvement of our proposed scheme is to filter the noises and interference added to the received RSSI signal; the detailed procedure is then provided with mathematical analysis. Finally, the experiment and simulation results are presented with analysis.
Motivational Effects of Badge Systems on Participation in Stack Exchange Social Q&A Online Community

Open, online social question and answer sites (SQAs) have captured the public attention in recent years. As SQAs become increasingly popular knowledge sharing platforms, issues about how open online community systems will evolve are becoming vital to our understanding of these systems. In this paper, we outline how an SQA site functions as a social learning community. The success of an SQA site depends not only on effectively organizing and delivering information, but also on whether it can attract participants and motivate them to contribute. We present early work investigating the effect of badges on users’ participation in an online SQAs community, Stack Exchange. This research-in-progress paper highlights factors that help users develop into literate and productive community contributors in social platforms and considers the design implications of these observations.
Guillain Barre Syndrome: A Single Center Experience

Objectives: To investigate the clinical, electrophysiological and epidemiological features of the patients who were diagnosed as Guillain Barre Syndrome (GBS) in our clinic. Methods: The clinical and demographical properties of 30 patients with GBS who were hospitalized in our neurology clinic between March 2013 and August 2017 were retrospectively examined in this study. Patients were divided into two groups according to the requirement of stay in the intensive care unit (ICU). Results: Patients were between 18-71 years range with 46.9 and 19.61 mean age. Seven of 30 patients (23.3%) were female, and 23 of them (76.7%) were male. Males were more dominant in the ICU (-) group (81% and 62%). A recent infection was found in 86.7% of patients. Upper respiratory tract infection (URTI) was more common in ICU (+) group whereas lower respiratory tract infection (LRTI) and acute gastroenteritis (AGE) were more common in the ICU (-) patients (p=0.007). Lower limb weakness was more frequent in the ICU (+) group (p=0.011). ICU (+) patients were lack of diplopia and dysarthria. Ataxia and dysphagia were relatively frequent in the ICU (+) group. Electrophysiological examinations revealed demyelinating polyneuropathy (26.7%), acute axonal polyneuropathy (30.1%) and acute sensorial polyneuropathy (13.3%). Demyelinating polyneuropathy was more common in the ICU (-) group, whereas acute motor and sensorial polyneuropathy (AMSAN) was more frequent in the ICU (+) group. In this study, 26.7 % of study patients required mechanical ventilation, and mortality rate was 6.8 %. Conclusion: URTI in ICU (+), LRTI and AGE in ICU (-) patients might be major trigger factors of GBS. Ascending weakness, dysphagia and ataxia was more frequent in ICU (+) GBS patients. Demyelinating PNP was predominant in the ICU (-) group, whereas AMSAN was more frequent in the ICU (+) patients. Multicenter randomized studies would be more useful for highlining the epidemiology of GBS.