Miracle-dz/UniFAR-FTUs huggingface dataset:
Mechanisms of Acute Alcohol Intoxication-Induced Modulation of Cyclic Mobilization of [Ca²⁺] in Rat Mesenteric Lymphatic Vessels.

BACKGROUND We have demonstrated that acute alcohol intoxication (AAI) increases the magnitude of Ca(2+) transients in pumping lymphatic vessels. We tested the contribution of extracellular Ca(2+) via L-type Ca(2+) channels and intracellular Ca(2+) release from the sarcoplasmic reticulum (SR) to the AAI-induced increase in Ca(2+) transients. METHODS AND RESULTS AAI was produced by intragastric administration of 30% alcohol to conscious, unrestrained rats; isovolumic administration of water served as the control. Mesenteric lymphatic vessels were isolated, cannulated, and loaded with Fura-2 AM to measure changes in intracellular Ca(2+). Measurements were made at intraluminal pressures of 2, 6, and 10 cm H2O. L-type Ca(2+) channels were blocked with nifedipine; IP-3 receptors were inhibited with xestospongin C; and SR Ca(2+) release and Ca(2+) pool (Ca(2+) free APSS) were achieved using caffeine. Nifedipine reduced lymphatic Ca(2+) transient magnitude in both AAI and control groups at all pressures tested, but reduced lymphatic contraction frequency only in the control group. Xestospongin C did not significantly change any of the Ca(2+) parameters in either group; however, fractional shortening increased in the controls at low transmural pressure. RyR (ryanodine receptor) activation with caffeine resulted in a single contraction with a greater Ca(2+) transient in lymphatics from AAI than those from controls. SR Ca(2+) pool was also greater in lymphatics isolated from AAI- than from control animals. CONCLUSIONS These data suggest that 1) L-type Ca(2+) channels contribute to the AAI-induced increase in lymphatic Ca(2+) transient, 2) blockage of IP-3 receptors could increase calcium sensitivity, and 3) AAI increases Ca(2+) storage in the SR in lymphatic vessels.
Identifying Influential People Based on Interaction Strength

Extraction of influential people from their respective domains has attained the attention of scholastic community during current epoch. This study introduces an innovative interaction strength metric for retrieval of the most influential users in the online social network. The interactive strength is measured by three factors, namely re-tweet strength, commencing intensity and mentioning density. In this article, we design a novel algorithm called IPRank that considers the communications from perspectives of followers and followees in order to mine and rank the most influential people based on proposed interaction strength metric. We conducted extensive experiments to evaluate the strength and rank of each user in the micro-blog network. The comparative analysis validates that IPRank discovered high ranked people in terms of interaction strength. While the prior algorithm placed some low influenced people at high rank. The proposed model uncovers influential people due to inclusion of a novel interaction strength metric that improves results significantly in contrast with prior algorithm.
Spatial, not temporal cues drive predictive orienting movements during navigation: a virtual reality study

A fundamental property of the human brain is the ability to make predictions of future sensory and motor events. We have recently found that steering manoeuvres when walking along curvilinear trajectories are controlled by an anticipatory guidance of the direction of head (and eyes). However it is unclear whether a time-related or space-related signal triggers such anticipatory head orienting movements. By simulating navigation along a multi-legged virtual corridor we show that anticipatory orienting movements are triggered (in standing subjects) by reaching specific locations rather than by the time to the approaching corridor's bend. Similar to what happens in car driving, specific spatial features of the route rather than time to collision seem to drive steering.
The Hexosamine Signaling Pathway: Deciphering the "O-GlcNAc Code"

A dynamic cycle of addition and removal of O-linked N-acetylglucosamine (O-GlcNAc) at serine and threonine residues is emerging as a key regulator of nuclear and cytoplasmic protein activity. Like phosphorylation, protein O-GlcNAcylation dramatically alters the posttranslational fate and function of target proteins. Indeed, O-GlcNAcylation may compete with phosphorylation for certain Ser/Thr target sites. Like kinases and phosphatases, the enzymes of O-GlcNAc metabolism are highly compartmentalized and regulated. Yet, O-GlcNAc addition is subject to an additional and unique level of metabolic control. O-GlcNAc transfer is the terminal step in a "hexosamine signaling pathway" (HSP). In the HSP, levels of uridine 5′-diphosphate (UDP)-GlcNAc respond to nutrient excess to activate O-GlcNAcylation. Removal of O-GlcNAc may also be under similar metabolic regulation. Differentially targeted isoforms of the enzymes of O-GlcNAc metabolism allow the participation of O-GlcNAc in diverse intracellular functions. O-GlcNAc addition and removal are key to histone remodeling, transcription, proliferation, apoptosis, and proteasomal degradation. This nutrient-responsive signaling pathway also modulates important cellular pathways, including the insulin signaling cascade in animals and the gibberellin signaling pathway in plants. Alterations in O-GlcNAc metabolism are associated with various human diseases including diabetes mellitus and neurodegeneration. This review will focus on current approaches to deciphering the "O-GlcNAc code" in order to elucidate how O-GlcNAc participates in its diverse functions. This ongoing effort requires analysis of the enzymes of O-GlcNAc metabolism, their many targets, and how the O-GlcNAc modification may be regulated. Glycosylation is not usually considered a "signaling" modification. However, a dynamic cycle of addition and removal of O-linked N-acetylglucosamine (O-GlcNAc) at serine and threonine residues is emerging as a key regulator of nuclear and cytoplasmic protein activity. More than a hundred proteins have been identified with this modification. Among these diverse targets are transcription factors, cytosolic enzymes, cytoskeletal proteins, and nuclear pore proteins. Like phosphorylation, this unique modification is dynamic and reversible, serving to either enhance or repress target protein activity. Most targets are also phosphoproteins, and the action of glycosylation and phosphorylation may be complementary or mutually exclusive. Whereas phosphorylation is controlled by many unique kinases and phosphatases, O-GlcNAc cycling is controlled by the efficient use of just two genes to produce differentially targeted enzymes. These enzymes are responsive to fluctuations in nutrient stores, allowing real-time control of signaling. This review will begin to answer how the enzymes of O-GlcNAc cycling are regulated and how the cycle may interface with other cellular signaling pathways.
Auditory Perception, Phonological Processing, and Reading Ability/Disability

Auditory perception has been proposed as one source of individual variation in the phonological abilities that play a critical role in skilled reading as well as in reading disabilities. A structural equation approach (LISREL, Jöreskog & Sörbom, 1990) was used to analyze relationships among auditory perception, phonological processing, and reading in a sample of 94 college undergraduates, 24 of whom met specific criteria for a reading disability. In the mathematical model that proved to be the best fit to the data, speech perception was strongly related to three of four phonological variables including short- and long-term auditory memory and phoneme segmentation. These phonological variables in turn were strongly related to reading. Nonverbal temporal processing was not significantly related to any of the phonological variables in the structural equations. It was concluded that speech perception, which was measured with speech repetition, syllable sequence discrimination, and degraded speech tasks, may contribute significantly to individual differences in the phonological abilities necessary for skilled reading.
Sensitive skin and stratunm corneum reactivity to household cleaning products

Products intended for individuals with sensitive skin are being increasingly developed by formulators of household cleaning products. However, there is currently no consensus about the definition and recognition of the biological basis of sensitive skin. We sought to determine the relation between the nature of environmental threat perceived as aggressive by panelists, and the stratum corneum reactivity lo household cleaning products as measured by the corneosurfametry lest. Results indicate substantial differences in irritancy potential between proprietary products. Corneosurfametry data show significant differences in stratum corneum reactivity between, on file one hand, individuals with cither non‐sensitive skin or skin sensitize to climate‐fabrics, and, on the other hand, individuals with detergent‐sensitive skin. It is concluded that sensitive skin is not one single condition. Sound information in rating detergent sensitive skin may be gained by corneosurfametry.
What is the long term outcome for children who fail to thrive? A systematic review

Aims: To ascertain the long term outcomes in children diagnosed as having failure to thrive (FTT). Methods: Systematic review of cohort studies. Medline, Psychinfo, Embase, Cinahl, Web of Science, Cochrane, and DARE databases were searched for potentially relevant studies. Inclusion criteria: cohort studies or randomised controlled trials in children <2 years old with failure to thrive defined as weight <10th centile or lower centile and/or weight velocity <10th centile, with growth, development, or behaviour measured at 3 years of age or older. Results: Thirteen studies met the inclusion criteria; eight included a comparison group, of which five included children identified in community settings. Two were randomised controlled trials. Attrition rates were 10–30%. Data from population based studies with comparison groups and which reported comparable outcomes in an appropriate form were pooled in a random effects meta-analysis. Four studies report IQ scores at follow up and the pooled standardised mean difference was −0.22 (95% CI −0.41 to −0.03). Two studies reported growth data as standard deviation scores. Their pooled weighted mean difference for weight was −1.24 SDS (95% CI −2.00 to −0.48), and for height −0.87 SDS (95% CI −1.47 to −0.28). No studies corrected for parental height, but two reported that parents of index children were shorter. Conclusions: The IQ difference (equivalent to ∼3 IQ points) is of questionable clinical significance. The height and weight differences are larger, but few children were below the 3rd centile at follow up. It is unclear to what extent observed differences reflect causal relations or confounding due to other variables. In the light of these results the aggressive approach to identification and management of failure to thrive needs reassessing.
Factors affecting sexual functioning of women in the mid-life years.

OBJECTIVE To model the interaction of hormones, symptoms and psychosocial factors on women's sexuality during the menopausal transition. DESIGN AND METHODS A prospective, observational study was carried out of a community-based sample of 438 Australian-born women aged 45-55 years at baseline. The study comprised six annual assessments in the women's own homes utilizing a core questionnaire, with rating scales for well-being and daily hassles, and a Personal Experiences Questionnaire as a measure of sexual functioning. Levels of follicle stimulating hormone (FSH), estradiol and inhibin were measured annually. Statistical analysis was performed by structural equation modelling. RESULTS The retention rate was 90% (final sample size after exclusions, n = 354). The normal fit index for the global model obtained was 0.92. There is a significant direct effect of menopausal status on vaginal dryness/dyspareunia, and an indirect effect on sexual responsivity via a direct effect of menopausal status on symptoms, which then affect well-being. Menopausal status reflects hormonal status. Feelings for the partner and the partner's sexual problems have direct effects on different aspects of sexual functioning. Other social variables such as paid work, interpersonal stress, daily hassles and educational level affect sexual functioning indirectly via effects on symptoms and well-being. CONCLUSIONS Psychosocial factors, symptoms and the menopausal transition affect women's sexual functioning during the mid-life years.
Low-Mutual-Coupling 60-GHz MIMO Antenna System With Frequency Selective Surface Wall

A new dielectric resonator antenna (DRA) for a millimeter-wave (mm-wave) multiple-input–multiple-output system is presented. Two approaches are exploited to reduce the mutual coupling between two antenna elements. First, a frequency selective surface (FSS) wall is inserted between the DRAs to reduce the free-space radiation. Then, two slots with different size acting like an <inline-formula><tex-math notation="LaTeX">$LC$</tex-math></inline-formula> resonator are etched from the common ground plane of the structure to reduce the surface current. The designed FSS has a wideband characteristic from 40 to 70 GHz. The FSS is optimized for the desired frequency of 57–63 GHz. A high isolation of −30 dB is achieved when both FSS wall and slots are used. A prototype of the structure is fabricated and measured. The results give a low correlation coefficient (<5 <inline-formula><tex-math notation="LaTeX">$e$</tex-math></inline-formula>–6) and a good agreement with simulation ones, indicating that the proposed antenna can provide spatial or pattern diversity to increase the data capacity of wireless communication systems at mm-wave bands.
Establishment of enzyme-linked immunosorbent assay using purified recombinant 83-kilodalton antigen of Borrelia burgdorferi sensu stricto and Borrelia afzelii for serodiagnosis of Lyme disease

The 83-kDa antigen of Borrelia burgdorferi was expressed as a recombinant protein in Escherichia coli and purified for use in an enzyme-linked immunosorbent assay (p83-ELISA). Antibodies to the 83-kDa antigen of both the immunoglobulin G (IgG) and IgM isotypes could be detected in all stages of Lyme disease. Sensitivity varied, depending on the clinical stage of illness. In early stages, as defined for 118 patients with erythema migrans, it was found to be 20% (24 of 118 patients: 7 with IgM, 16 with IgG, and 1 with IgM and IgG). Of the patients with late-stage Lyme arthritis and acrodermatitis chronica atrophicans, 94% (16 of 17:2 with IgM and IgG and 14 with IgG) and 86% (36 of 42:2 with IgG and IgM and 34 with IgG) revealed positive results in the p83-ELISA, respectively. p83 displays sequence heterogeneity according to the genomospecies, but when the reactions of serum specimens from acrodermatitis chronica atrophicans patients and arthritis patients with p83 derived from representative strains of B. burgdorferi sensu stricto and Borrelia afzelii in ELISAs were compared, no differences in specificity and sensitivity were seen. When 82 serum specimens from healthy controls were tested, none had IgG and only 3 (4%) had IgM antibodies, indicating a high specificity. Positive reactions with antibodies against Treponema pallidum (1 of 37 patients; IgG) and Epstein-Barr virus (1 of 44 patients; IgM) and with autoantibodies of various specificities (1 of 53 patients; IgG) were seen with < 3% of the serum samples te11111111111111111111 high speficicity for B. burgdorferi.2+ 13% for IgM antibodies, the IgM p83-ELISA provided little diagnostic information for Lyme disease, whereas the IgG p83-ELISA appears to be a suita ;e test for serodiagnosis of advanced-stage Lyme disease.
Surgical guided tissue regeneration treatment of advanced periodontal defects: a 5-year follow-up study.

OBJECTIVES To study the 5-year outcome of combined use of guided tissue regeneration (GTR) barriers and bovine bone in advanced periodontal defects. MATERIAL AND METHODS In each of 24 patients, one defect was surgically exposed, debrided, filled with bovine bone, and covered with a bioresorbable barrier. Re-examinations were made after 1, 3, and 5 years. RESULTS Average full-mouth plaque scores (FMPS) were 14.5% at baseline and 10.7%, 9.8%, and 18.9% after 1, 3, and 5 years, respectively. Mean probing pocket depth (PPD) was 10.0 mm at baseline. Mean PPD reduction was 5.2 mm after 1 year, 5.6 mm after 3 years, and 5.3 mm after 5 years. Mean gingival recession was 1.0 mm after 1 year, 1.6 mm after 3 years, and 1.3 mm after 5 years. Mean gain in clinical attachment level (CAL) was 4.2 mm at the 1-year, 4.1 mm at the 3-year, and 4.3 mm at the 5-year examination. Smoking significantly influenced CAL change at all re-examinations. FMPS were significantly correlated with radiographic defect depth at the 5-year examination and CAL with smoking and FMPS at the 3-year examination. CONCLUSION Advanced periodontal defects can be successfully treated with the combined use of GTR barriers and bovine bone to substantially reduce PPD and achieve a stable, long-term gain of CAL.
Health Care Trajectories for Children With ADHD in France: Results From the QUEST Survey

Objective: The objective of this study is to retrospectively describe the pathway toward ADHD diagnosis and treatment, and identify potential areas for improvement. Method: Parent-reported questionnaires were collected by a national sample of ADHD specialists. Results: In total, 473 complete questionnaires were analyzed. Initial onset of ADHD symptoms was reported at a mean age of 4.45 years. Mean age at diagnosis was 8.07 years, and half of the families had seen at least three health care professionals previously. Psychiatrists were most commonly consulted. A “combined” (89% boys) and inattentive (49% boys) profile was identified. Diagnosis was made 1 year later for the latter group. Two thirds of patients received pharmacological treatment. The delay in diagnosis was identified as the main source of concern for caregivers. Conclusion: The 4-year delay in diagnosis may represent a loss of opportunity. Training health care professionals in the core symptoms of ADHD may help reduce disparities and improve patient trajectory.
Sahlgrenska Academy Self-reported Cognitive Impairment Questionnaire (SASCI-Q) – a research tool discriminating between subjectively cognitively impaired patients and healthy controls

ABSTRACT Background: Subjective cognitive impairment (SCI) is a potential early marker for actual cognitive decline. The cognitive manifestation of the SCI stage is, however, largely unknown. Self-report instruments developed especially for use in the SCI population are lacking, and many SCI studies have not excluded mild cognitive impairment and dementia. We developed and tested a patient-based questionnaire on everyday cognitive function aiming to discriminate between patients with subjective, but not objective, cognitive impairment and healthy controls. Methods: Individuals experiencing cognitive impairment were interviewed to generate a pool of items. After condensing to 97 items, we tested the questionnaire in 93 SCI patients seeking care at a memory clinic (age M = 64.5 years, Mini-Mental State Examination (MMSE) M = 29.0) and 50 healthy controls (age M = 69.6 years, MMSE M = 29.3). Further item reduction was conducted to maximize that remaining items would discriminate between SCI patients and controls, using a conservative α level and requiring medium to high effect sizes. Internal consistency reliability and convergent validity was subsequently examined. Results: Forty-five items discriminated between the groups, resulting in the Sahlgrenska Academy Self-reported Cognitive Impairment Questionnaire (SASCI-Q). Internal consistency was high and correlations to a single question on memory functioning were of medium to large sizes. Most remaining items were related to the memory domain. Conclusion: The SASCI-Q discriminates between SCI patients and healthy controls and demonstrates satisfying psychometric properties. The instrument provides a research method for examining SCI and forms a foundation for future examining which SCI symptoms predict objective cognitive decline. The cognitive manifestation of the SCI stage is mostly related to experiences of memory deficits.
Improved Outcomes of Kidney Transplantation in Infants (Age < 2 years): A Single-Center Experience

Background Infants (age, < 2 years) with end-stage renal disease (ESRD) have increased morbidity and mortality. We evaluated our long-term outcomes of kidney transplants (KTx) in infants. Methods Between 1984 and 2014, 136 infants underwent KTx. We examined trends in survival rates and complications by era (1984-1993 [era 1], 1994-2003 [era 2], 2004-2014 [era 3]). Results Patients were 92.6% white and 70.6% males. Posttransplant (Tx) initial length of hospital stay declined 37% over the 30-year period (P <0.01). Ten-year death-censored graft survival improved from 60% (era 1) to 80% (era 2) (P = 0.04). The incidence of acute rejection, graft thrombosis, cytomegalovirus, and urine leaks did not significantly change across eras. Frequency of Epstein-Barr virus diagnosis (era 2 vs era 3, P < 0.01) increased. Post-Tx lymphoproliferative disorder incidence was increased in era 2 compared with eras 1 and 3 (P = 0.03). Conclusions Infants deserve earlier consideration for KTx. Length of initial hospital stay and patient and graft survival rates after KTx have improved in infants since 1984.
Link Regimes Analysis for Partial Decode-Forward Two-Way Relay Transmission

We propose a composite decode-forward (DF) scheme for the two-way relay channel in the full-duplex mode by combining coherent, independent, and partial relaying strategies. The relay partially decodes each user’s information in each block and forwards this information coherently with the source user to the destination user in the next block as in block Markov coding. In addition, the relay independently broadcasts a binning index of both users’ decoded information parts in the next block as in independent network coding. Each technique has a different impact on the relay power usage and the rate region. We further consider the independent and partial DF scheme for its more practical channel state information requirements, and derive in closed-form link regimes when this scheme achieves a strictly larger rate region than just time sharing between its constituent techniques, direct transmission, and independent DF relaying, and when it reduces to a simpler scheme. The analytical approach is based on maximizing the weighted composite DF sum rate and comparing with the outermost time-sharing line connecting corner points of rate regions of the constituent techniques. Numerical results demonstrate significant rate gains by performing link adaptation of the composite scheme based on the identified link regimes.
Experiences of Online Harassment Among Emerging Adults

Online harassment is a growing problem. Among college students, 43% report some experience receiving harassing messages. Previous research has shown negative online experiences to be typical among “emerging adults” (especially college students), and these incidents may be related to normative developmental behaviors, such as “on-again-off-again” romantic relationships. Study hypotheses were derived from previous research. Undergraduate student respondents (N = 342) were surveyed about their experiences with online harassment, emotional responses to online harassment, and their relationship with the sender of harassing messages. Findings suggest that online harassment is linked to issues of intimate partner violence. Those who were harassed by a partner reported feelings of depression and anxiety. Using a gendered framework to explore online harassment is warranted because young women who are 18 to 29 years of age have higher rates of intimate partner violence than other demographic groups. Findings suggest future research is needed to understand the time ordering of these issues.