Miracle-dz/UniFAR-FTUs huggingface dataset:
Infant gut immunity: a preliminary study of IgA associations with breastfeeding

Secretory immunoglobulin A (IgA) plays a critical role in gut mucosal immune defense. Initially provided by breastmilk, IgA production by the infant gut is gradually stimulated by developing gut microbiota. This study reports associations between infant fecal IgA concentrations 4 months after birth, breastfeeding status and other pre/postnatal exposures in 47 infants in the Canadian Healthy Infant Longitudinal Development cohort. Breastfed infants and first-born infants had higher median fecal IgA concentrations (23.11 v. 9.34 µg/g protein, P<0.01 and 22.19 v. 8.23 µg/g protein, P=0.04). IgA levels increased successively with exclusivity of breastfeeding (β-coefficient, 0.37, P<0.05). This statistical association was independent of maternal parity and household pets. In the absence of breastfeeding, female sex and pet exposure elevated fecal IgA to levels found in breastfed infants. In addition to breastfeeding, infant fecal IgA associations with pre/postnatal exposures may affect gut immunity and risk of allergic disease.
Mechanisms of progesterone action in inhibiting prematurity

Progesterone is a steroid hormone that plays an integral role in each step of human pregnancy. In early pregnancy, progesterone produced by the corpus luteum is critical to the maintenance of early pregnancy until the placenta takes over this function at 7 to 9 weeks of gestation, hence its name (pro-gestational steroid hormone). The role of progesterone in later pregnancy, however, is less clear. It has been proposed that progesterone may be important in maintaining uterine quiescence in the latter half of pregnancy by limiting the production of stimulatory prostaglandins and inhabiting the expression of contraction-associated protein genes within the myometrium. Although systemic progesterone withdrawl may not correlate directly with the onset of labour in humans, there is increasing evidence to suggest that progesterone exerts its influence indirectly via a ‘functional’ withdrawl at the level of the uterus. The molecular mechanisms by which progesterone is able to maintain uterine quiescence and prevent preterm birth in some high-risk women are not clear. Six putative mechanisms have been proposed in the literature by both US and other investigators and are explored in this review.
Change in Blood Pressure during Pubertal Insulin Resistance

To examine the levels and relationships of blood pressure and insulin during puberty, blood pressure and serum insulin were measured in 3596 subjects, aged 3-18 y, whose pubertal status was graded according to the Tanner classification. The same study protocol was repeated in two follow-up surveys 3 and 6 y later for 2991 6-21-y-old subjects and 2799 9-24-y-old subjects, respectively. There was a 37-66% increase in insulin at Tanner stage 3 (pubic hair) among the female subjects and at Tanner stage 5 (pubic hair) among the male subjects, after which insulin started to decrease. The mean systolic and diastolic blood pressure increased steadily throughout puberty. The rise in blood pressure continued during early adulthood, despite the decrease in serum insulin. The correlation between systolic blood pressure and insulin measured in the same year was weak at each pubertal stage after standardization for weight, except among the female subjects at mid puberty. There was no relation between diastolic blood pressure and insulin. Adult systolic blood pressure could be predicted by pubertal insulin among the male subjects after adjustment for age and weight (partial correlation coefficient 0.21), but among the female subjects this relation was trivial (partial correlation coefficient 0.08). We conclude that the correlation between insulin and actual blood pressure vanishes during puberty, whereas pubertal insulin and future adult male systolic blood pressure seem to correlate.
Worker Voice in America: Is There a Gap between What Workers Expect and What They Experience?

This article is the fifth in a series to celebrate the 70th anniversary of the ILR Review. The series features articles that analyze the state of research and future directions for important themes this journal has featured over many years of publication. The decline in unionization experienced in the United States over the past 40 years raises a question of fundamental importance to workers, society, and the field of industrial relations: Have workers lost interest in having a voice at work, or is there a gap between workers’ expectations for a voice and what they actually experience? And if a “voice gap” exists, what options are available to workers to close that gap? The authors draw on a nationally representative survey of workers that both updates previous surveys conducted in 1977 and 1995 and goes beyond the scope of these previous efforts to consider a wider array of workplace issues and voice options. Results indicate that workers believe they should have a voice on a broad set of workplace issues, but substantial gaps exist between their expected and their actual level of voice at work. Nearly 50% of non-union workers say they would vote for a union, compared to approximately one-third in the two prior national surveys, which points to continued interest in unions as a voice mechanism. Additionally, the authors find significant variation in the rates of use of different voice options and workers’ satisfaction with those options. The results suggest that a sizable voice gap exists in American workplaces today, but at the same time, no one voice option fits all workers or all issues.
Does Short-Maturity Debt Discipline Managers? Evidence from Cash-Rich Firms' Acquisition Decisions

We study the disciplinary role of short-maturity debt in cash-rich firms. We report evidence that such debt mitigates cash-rich firms' overinvestment in acquisitions. The disciplinary role is mostly concentrated among cash-rich firms that are weakly governed and have limited access to the public debt market and is also more pronounced for cash-rich firms that operate in less competitive industries. Furthermore, for cash-rich acquirers, high levels of short-maturity debt are associated with higher acquisition announcement returns and better post-acquisition operating performance. Overall, our results highlight the effective role of short-maturity debt in reducing agency cost.
IVS6+5G>A found in Wiskott–Aldrich syndrome and X‐linked thrombocytopenia in a Korean family

Wiskott–Aldrich syndrome (WAS) and X‐linked thrombocytopenia (XLT) are caused by a mutation in the WAS gene on Xp11.22. We report two patients with IVS6+5G>A of WAS in a Korean family. The proband presented with classic WAS, whereas his maternal cousin had symptoms limited to XLT. Their mothers were proved to be carriers. The IVS6+5G>A mutation was reported to result in incomplete splicing of the donor site and typically associated with mild form of disease, XLT. Our observation of the intrafamilial variability of clinical manifestations of WAS further expands the genotype–phenotype correlations and suggests the presence of modifying genetic factors. Pediatr Blood Cancer 2012; 58: 297–299. © 2011 Wiley Periodicals, Inc.
Diffusive Molecular Communications with Reactive Signaling

This paper focuses on molecular communication (MC) systems where the signaling molecules may participate in a reversible bimolecular reaction in the channel. The motivation for studying these MC systems is that they can realize the concept of constructive and destructive signal superposition, which leads to favorable properties such as inter-symbol interference (ISI) reduction and avoiding environmental contamination due to continuous release of molecules into the channel. This work first derives the maximum likelihood (ML) detector for a binary MC system with reactive signaling molecules under the assumption that the detector has perfect knowledge of the ISI. The performance of this genie-aided ML detector yields an upper bound on the performance of any practical detector. In addition, two suboptimal detectors of different complexity are proposed. The proposed ML detector as well as one of the suboptimal detectors require the channel response (CR) of the considered MC system. Moreover, the CR is needed for the performance evaluation of all proposed detectors. However, analyzing MC with reactive signaling is challenging since the underlying partial differential equations that describe the reaction-diffusion mechanism are coupled and non-linear. Therefore, an algorithm is developed in this paper for efficient computation of the CR to any arbitrary transmit symbol sequence. The accuracy of this algorithm is validated via particle-based simulation. Simulation results using the developed CR algorithm show that the performance of the proposed suboptimal detectors can approach that of the genie-aided ML detector. Moreover, these results show that MC systems with reactive signaling have superior performance relative to those with non-reactive signaling due to the reduction of ISI enabled by the chemical reactions.
Identification, Expression, and Regulation of Anti-Müllerian Hormone Type-II Receptor in the Embryonic Chicken Gonad1

ABSTRACT Anti-Müllerian hormone (AMH) signaling is required for proper development of the urogenital system in vertebrates. In male mammals, AMH is responsible for regressing the Müllerian ducts, which otherwise develop into the fallopian tubes, oviducts, and upper vagina of the female reproductive tract. This role is highly conserved across higher vertebrates. However, AMH is required for testis development in fish species that lack Müllerian ducts, implying that AMH signaling has broader roles in other vertebrates. AMH signals through two serine/threonine kinase receptors. The primary AMH receptor, AMH receptor type-II (AMHR2), recruits the type I receptor, which transduces the signal intracellularly. To enhance our understanding of AMH signaling and the potential role of AMH in gonadal sex differentiation, we cloned chicken AMHR2 cDNA and examined its expression profile during gonadal sex differentiation. AMHR2 is expressed in the gonads and Müllerian ducts of both sexes but is more strongly expressed in males after the onset of gonadal sex differentiation. In the testes, the AMHR2 protein colocalizes with AMH, within Sertoli cells of the testis cords. AMHR2 protein expression is up-regulated in female embryos treated with the estrogen synthesis inhibitor fadrozole. Conversely, knockdown of the key testis gene DMRT1 leads to disruption of AMHR2 expression in the developing seminiferous cords of males. These results indicate that AMHR2 is developmentally regulated during testicular differentiation in the chicken embryo. AMH signaling may be important for gonadal differentiation in addition to Müllerian duct regression in birds.
New Data, New Approaches and New Evidence: A Policy Synthesis

The Republic of South Africa faces the imperative of escaping economic stagnation. This paper seeks to synthesize results from a series of research efforts, including but not limited to the work conducted under the UNU-WIDER project on ‘Regional growth and development in Southern Africa’, and consider policy options for escaping economic stagnation. The focus is on South Africa and South African policies yielding relatively quick dividends in terms of growth and taking the rest of the world as given. Four broad implications are presented. These could form part of a concerted effort to escape from South Africa’s long running economic malaise.
zic Gene expression marks anteroposterior pattern in the presumptive neurectoderm of the zebrafish gastrula

Anteroposterior (A/P) patterning of the vertebrate neurectoderm begins early during development. In vitro explant assays have been used to show that an A/P subdivision of the zebrafish neurectoderm is in place by early gastrulation. However, no direct markers of this subdivision had been described. We report isolation of two members of the zic gene family, zic2 and zic3, which mark distinct regions in the developing nervous system. zic3 is expressed in early gastrula embryos in a posterior domain, directly demonstrating that A/P pattern is present in the future neurectoderm by this stage. Analysis of mutants in genes encoding bone morphogenetic proteins (BMPs) shows that dorsal restriction of zic3 expression requires intact BMP function, and that posterior restriction of zic3 expression is regulated independently of BMP signaling. These data show an early subdivision of the A/P axis in the presumptive neurectoderm. © 2001 Wiley‐Liss, Inc.
Political Skill at Work: Impact on Work Effectiveness

In today's flatter, matrix-based organizations, the ability to influence and motivate others is key to both individual and organizational success. This is the essence of political skill - and everyone wants more of it. But what do we know about how it really works? Political Skill at Work is the first thorough examination of an ability that is as subtle as it is powerful. The result of more than 15 years of research, this well-documented study is rich with examples of individuals using political skill to succeed in the corporate world, government, education and sports. Combining scholarship with practical advice, the authors explore what political skill is (and isn't), why and how it works and how it can be measured and developed. The authors define four key dimensions of political skill: social astuteness, interpersonal influence, networking ability and apparent sincerity. Their 18-item Political Skill Inventory, which is easily self-administered and scored, measures strength in these areas. Techniques to improve each ability are discussed, along with an arsenal of political tactics that contribute to professional success. Why is political skill so important in the workplace? The authors uncover the role it plays in getting hired, building a reputation, raising job performance and enhancing leadership abilities. By increasing self-confidence and control, it even correlates with reduced job stress. Political skill is a strong predictor of job success. For managers, leaders and anyone interested in human resource and organization development, Political Skill at Work is vital reading.
Postmitotic, postmigrational expression of tyrosine hydroxylase in olfactory bulb dopaminergic neurons

The developmental expression of tyrosine hydroxylase (TOH) was studied in a large, specific population of dopaminergic (DA) neurons in the main olfactory bulb (MOB) of the rat. These DA neurons comprise an anatomically distinctive population that has been well characterized in the adult hamster (Davis and Macrides, 1983) and rat (Halasz et al., 1981; Baker et al., 1983, 1984). We addressed a basic question in developmental neurobiology: What factors regulate the expression of neuronal transmitter phenotype during development? Olfactory bulb DA neurons are born in the ventricular and subependymal zones and migrate through all intervening layers to the most superficial layer in the bulb (Altman, 1969; Bayer, 1983). The time of TOH expression in these neurons was determined using immunohistochemistry and light microscopic image-analysis techniques. The results indicate that TOH phenotype is not expressed when the cells are born in the subependymal zone nor during their migration to the periglomerular region but only after they reached their final destination, the glomerular layer. This suggests that epigenetic factors associated with the glomeruli initiate the expression of the key transmitter synthesizing enzyme in these neurons. Primary olfactory neurons in the nasal epithelium project exclusively to glomeruli of the MOB; removal of this input in adult rats (Kawano and Margolis, 1982; Baker et al., 1983, 1984), mice (Nadi et al., 1981; Baker et al., 1983), dogs (Nadi et al., 1981), and hamsters (Kream et al., 1984) appears to down-regulate the expression of the TOH in periglomerular cells. The present results suggested that the input from the primary olfactory nerve is also necessary for the initial expression of the TOH phenotype. In support of this notion, we found that lesions of the olfactory nerve during the first postnatal week caused a significant reduction in the number of TOH-positive juxtaglomerular neurons in the following weeks. Thus, the olfactory nerve appears to be necessary for both the initiation and maintenance of TOH expression in olfactory bulb neurons. These findings suggest that specific cell-cell interactions play a key role in CNS neuronal transmitter phenotype regulation. (ABSTRACT TRUNCATED AT 400 WORDS)
Optimal Generation Planning for a Thermal System with Pumped-Storage Based on Analytical Production Costing Model

This paper presents a new algorithm for the optimal long-range generation planning for a thermal system with pumped-storage plants. The algorithm is based upon the analytical production costing model developed under the assumption of Gaussian probabilistic distribution of random load fluctuations and plant outages. The optimization problem consists of the master problem to determine the annual investment, and the pumped-storage subproblem to determine the optimal pumped-storage operation. The master problem is formulated as a Hamiltonian minimization problem, and the pumped-storage subproblem is solved using the concept of peak-shaving operation on the original load curve.
CLINICAL STUDY: Predicting the effect of naltrexone and acamprosate in alcohol‐dependent patients using genetic indicators

Acamprosate and naltrexone are effective medications in the treatment of alcoholism. However, effect sizes are modest. Pharmacogenomics may improve patient‐treatment‐matching and effect sizes. It is hypothesized that naltrexone exerts its effect through genetic characteristics associated with the dopaminergic/opioidergic positive reinforcement system, whereas acamprosate works through the glutamatergic/GABAergic negative reinforcement system. Alcohol‐dependent subjects were randomly assigned to either acamprosate or naltrexone. Subjects participated in a cue‐exposure experiment at the day before and at the last day of medication. Reductions in cue‐induced craving and physiological cue reactivity were measured. Differential effects of naltrexone and acamprosate on these outcomes were tested for different polymorphisms of the opioid, dopamine, glutamate and GABA‐receptors. Significant matching effects were found for polymorphisms at the DRD2, GABRA6 and GABRB2 gene. In addition, a trend was found for the OPRM1 polymorphism. This provides evidence for the matching potential of genotypes. It is expected that more effective treatments can be offered when genetic information is used in patient‐treatment‐matching.
Properties of voltage‐gated potassium currents in nucleated patches from large layer 5 cortical pyramidal neurons of the rat

1 Voltage‐gated potassium currents were studied in nucleated outside‐out patches obtained from large layer 5 pyramidal neurons in acute slices of sensorimotor cortex from 13‐ to 15‐day‐old Wistar rats (22–25 °C). 2 Two main types of current were found, an A‐current (IA) and a delayed rectifier current (IK), which were blocked by 4‐aminopyridine (5 mm) and tetraethylammonium (30 mm), respectively. 3 Recovery from inactivation was mono‐exponential (for IA) or bi‐exponential (for IK) and strongly voltage dependent. Both IA and IK could be almost fully inactivated by depolarising prepulses of sufficient duration. Steady‐state inactivation curves were well fitted by the Boltzmann equation with half‐maximal voltage (V½) and slope factor (k) values of −81.6 mV and −6.7 mV for IA, and −66.6 mV and −9.2 mV for IK. Peak activation curves were described by the Boltzmann equation with V½ and k values of −18.8 mV and 16.6 mV for IA, and −9.6 mV and 13.2 mV for IK. 4 I A inactivated mono‐exponentially during a depolarising test pulse, with a time constant (∼7 ms) that was weakly dependent on membrane potential. IK inactivated bi‐exponentially with time constants (∼460 ms, ∼4.2 s) that were also weakly voltage dependent. The time to peak of both IA and IK depended strongly on membrane potential. The kinetics of IA and IK were described by a Hodgkin‐Huxley‐style equation of the form mNh, where N was 3 for IA and 1 for IK. 5 These results provide a basis for understanding the role of voltage‐gated potassium currents in the firing properties of large layer 5 pyramidal neurons of the rat neocortex.
Modulation of Ghrelin O-Acyltransferase Expression in Pancreatic Islets

Background: Ghrelin, the only identified circulating orexigenic signal, is unique in structure in which a specific acyl-modification of its third serine occurs. This acylation is necessary for ghrelin to bind to its receptor and to exert its biologic activity, which is catalyzed by ghrelin O-acyltransferase (GOAT). Although ghrelin is mainly secreted from gastric X/A like endocrine cells, it is also expressed in pancreatic islet cells and regulates insulin secretion. In this study, we examined the expression and regulation of GOAT in pancreas. Methods: GOAT mRNA and immunoreactivity were examined in pancreatic islets and INS-1 cells by RT-PCR and immunofluorescent staining or Western blotting. Results: Insulin inhibits the expression of GOAT mRNA and GOAT promoter activity in a dose and time-dependent manner. The mammalian target of rapamycin (mTOR) is activated by insulin. Blocking mTOR signaling by either rapamycin or overexpression of its negative regulator tuberous sclerosis complex 1 (TSC1) or TSC2 attenuates the inhibitory effect of insulin on the transcription and translation of GOAT. Conclusion: Our study suggests that GOAT is present in pancreatic islet cells and that insulin inhibits the expression of GOAT via the mediation of mTOR signaling.
The Effect of Music Therapy in Patients with Huntington's Disease: A Randomized Controlled Trial.

BACKGROUND Music therapy may have beneficial effects on improving communication and expressive skills in patients with Huntington's disease (HD). Most studies are, however, small observational studies and methodologically limited. Therefore we conducted a multi-center randomized controlled trial. OBJECTIVE To determine the efficacy of music therapy in comparison with recreational therapy in improving quality of life of patients with advanced Huntington's disease by means of improving communication. METHOD Sixty-three HD-patients with a Total Functional Capacity (TFC) score of ≤7, admitted to four long-term care facilities in The Netherlands, were randomized to receive either group music therapy or group recreational therapy in 16 weekly sessions. They were assessed at baseline, after 8, 16 and 28 weeks using the Behaviour Observation Scale for Huntington (BOSH) and the Problem Behaviour Assessment-short version (PBA-s). A linear mixed model with repeated measures was used to compare the scores between the two groups. RESULTS Group music therapy offered once weekly for 16 weeks to patients with Huntington's disease had no additional beneficial effect on communication or behavior compared to group recreational therapy. CONCLUSION This was the first study to assess the effect of group music therapy on HD patients in the advanced stages of the disease. The beneficial effects of music therapy, recorded in many, mainly qualitative case reports and studies, could not be confirmed with the design (i.e. group therapy vs individual therapy) and outcome measures that have been used in the present study. A comprehensive process-evaluation alongside the present effect evaluation is therefore performed.