Miracle-dz/UniFAR-FTUs huggingface dataset:
Correlation Between Myopia and Major Biometric Parameters of the Eye: A Retrospective Clinical Study

Purpose. To investigate the relationship between myopia and changes in ocular biometry and macular thickness in young adults. Methods. Two hundred sixteen eyes from 108 adults (23.3 ± 6.3 years old, mean ± SD) were measured for refractive status, corneal curvature, and axial components of the eye. Macular thickness was measured in 118 eyes (59 subjects) by optical coherence tomography. All eyes were categorized into emmetropia, low, moderate, or high myopia based on the refractive status. Biometric results from right eyes of all subjects were compared between sub-groups with the linear correlation analyzed between refraction and other parameters for each group. Results. The vitreous chamber depth was longest in high myopia, followed by the moderate myopia group, the low myopia group and finally the emmetropic group (p ≤ 0.004). Average thickness of the inner and outer ring macula in all the myopia groups was significantly thinner than in the emmetropia group (p ≤ 0.021). Among different macular regions, the inferior quadrant of the outer ring was consistently the thinnest in myopia. Corneal curvature, anterior chamber depth, and lens thickness measures were not associated with myopia. Conclusions. Myopia in young adults is associated with an increase in vitreous length and a decrease in para-foveal thickness. The thinness in the retinal region inferior to the fovea appears to be more highly correlated with myopia than any other retinal region.
Acute Oxidative Effect and Muscle Damage after a Maximum 4 Min Test in High Performance Athletes

The purpose of this investigation was to determine lipid peroxidation markers, physiological stress and muscle damage in elite kayakers in response to a maximum 4-min kayak ergometer test (KE test), and possible correlations with individual 1000m kayaking performances. The sample consisted of twenty-three adult male and nine adult female elite kayakers, with more than three years’ experience in international events, who voluntarily took part in this study. The subjects performed a 10-min warm-up, followed by a 2-min passive interval, before starting the test itself, which consisted of a maximum 4-min work paddling on an ergometer; right after the end of the test, an 8 ml blood sample was collected for analysis. 72 hours after the test, all athletes took part in an official race, when then it was possible to check their performance in the on site K1 1000m test (P1000m). The results showed that all lipoproteins and hematological parameters tested presented a significant difference (p≤0.05) after exercise for both genders. In addition, parameters related to muscle damage such as lactate dehydrogenase (LDH) and creatine kinase (CK) presented significant differences after stress. Uric acid presented an inverse correlation with the performance (r = -0.76), while CK presented a positive correlation (r = 0.46) with it. Based on these results, it was possible to verify muscle damage and the level of oxidative stress caused by indoor training with specific ergometers for speed kayaking, highlighting the importance of analyzing and getting to know the physiological responses to this type of training, in order to provide information to coaches and optimize athletic performance.
Increased urinary transferrin excretion predicts microalbuminuria in patients with type 2 diabetes.

OBJECTIVE We studied whether increased urinary transferrin excretion rates (TERs) (urinary transferrin-to-urinary creatinine ratio > or = 107 micrograms/mmol, which is the sum of an average and 2 SDs in 431 healthy nondiabetic individuals) would predict the development of microalbuminuria (urinary albumin-to-urinary creatinine ratio > or = 2.8 mg/mmol) in patients with type 2 diabetes and normal urinary albumin excretion rates (AERs) (albumin-to-creatinine ratio < 2.8 mg/mmol). We also studied the influence of blood pressure, glycemic control, and serum levels of lipids and apolipoproteins on the later development of microalbuminuria. RESEARCH DESIGN AND METHODS In 77 diabetic patients with normal AER, AER and TER were measured at baseline and after 24 months of follow-up. Blood pressure, glycemic control, and serum levels of lipids and apolipoproteins were measured at 1- to 2-month intervals during the follow-up period. RESULTS Of the 16 patients who initially had increased TER, 5 (31%) developed microalbuminuria. In contrast, of the 61 who initially had normal TER, 4 (7%) developed microalbuminuria (P = 0.016). At baseline, no difference was found in age, sex, diabetes duration, diabetic medications, prevalence of hypertension, blood pressure, HbA1c levels, or serum lipid and apolipoprotein concentrations between the two group of patients with normal and increased TER. There was also no difference in duration of hypertension and prevalence of users of ACE inhibitors between two subgroups of hypertensive patients with normal and increased TER. During the 24 month follow-up period, those whose condition progressed to microalbuminuria had increased serum levels of triglycerides (1.87 +/- 0.49 vs. 1.29 +/- 0.64 mmol/l, P = 0.003) and apolipoprotein B (114 +/- 20 vs. 102 +/- 24 mg/dl, P = 0.05) and tended to have increased HbA1c levels (7.7 +/- 1.0 vs. 7.1 +/- 1.1%, P = 0.10) compared with those in whom microalbuminuria did not develop. Blood pressure, however, did not differ. In multivariate stepwise logistic regression analysis, the association between increased TER at baseline and subsequent development of microalbuminuria was significant (odds ratio 7.04 [95% CI 1.02-48.5], P = 0.04). CONCLUSIONS In patients with type 2 diabetes and normal AER, increased TER may predict the development of microalbuminuria and abnormalities in triglyceride-rich lipoprotein metabolism, and poor glycemic control may be associated with this progression.
A Political Explanation of Economic Growth: State Survival, Bureaucratic Politics, and Private Enterprises in the Making of Taiwan’s Economy, 1950–1985

Taiwan is a classic case of export-led industrialization. But unlike South Korea and Japan, where large firms have been the major exporters, before the late 1980s Taiwan's successful exporters were overwhelmingly small- and medium-sized enterprises (SMEs). The SMEs became the engine of the entire economy, yet for many years the state virtually ignored the SMEs and their role as exporters. What factors account for the success of the SMEs and their benign neglect by the state? The key was a strict division of labor: state and large private enterprises jointly monopolized the domestic market. This gave the SMEs a free run in export markets. How did this industrial structure come into being? The author argues that it was an unintended consequence of the state's policy toward the private sector and its political strategies for managing societal forces. Indeed, Taiwan's unique industrial structure was shaped by both the witting and the unwitting interactions of the state and the private sector. Moreover, as the author shows, this industrial policy was a product of the internal politics of the economic bureaucracy, and the formulation and implementation of economic policy hinged on mechanisms for solving differences within the state.
The grammatical morpheme deficit in moderate hearing impairment.

BACKGROUND Much remains unknown about grammatical morpheme (GM) acquisition by children with moderate hearing impairment (HI) acquiring spoken English. AIMS To investigate how moderate HI impacts on the use of GMs in speech and to provide an explanation for the pattern of findings. METHODS & PROCEDURES Elicited and spontaneous speech data were collected from children with moderate HI (n = 10; mean age = 7;4 years) and a control group of typically developing children (n = 10; mean age = 3;2 years) with equivalent mean length of utterance (MLU). The data were analysed to determine the use of ten GMs of English. Comparisons were made between the groups for rates of correct GM production, for types and rates of GM errors, and for order of GM accuracy. OUTCOME & RESULTS The findings revealed significant differences between the HI group and the control group for correct production of five GMs. The differences were not all in the same direction. The HI group produced possessive -s and plural -s significantly less frequently than the controls (this is not simply explained by the perceptual saliency of -s) and produced progressive -ing, articles and irregular past tense significantly more frequently than the controls. Moreover, the order of GM accuracy for the HI group did not correlate with that observed for the control group. Various factors were analysed in an attempt to explain order of GM accuracy for the HI group (i.e. perceptual saliency, syntactic category, semantics and frequency of GMs in input). Frequency of GMs in input was the most successful explanation for the overall pattern of GM accuracy. Interestingly, the order of GM accuracy for the HI group (acquiring spoken English as a first language) was characteristic of that reported for individuals learning English as a second language. An explanation for the findings is drawn from a factor that connects these different groups of language learners, i.e. limited access to spoken English input. CONCLUSIONS It is argued that, because of hearing factors, the children with HI are below a threshold for intake of spoken language input (a threshold easily reached by the controls). Thus, the children with HI are more input-dependent at the point in development studied and as such are more sensitive to input frequency effects. The findings suggest that optimizing or indeed increasing auditory input of GMs may have a positive impact on GM development for children with moderate HI.
Comparison of laparoscopic vs open liver lobectomy (segmentectomy) for hepatocellular carcinoma.

AIM To investigate the effects of laparoscopic hepatectomy for the treatment of hepatocellular carcinoma (HCC). METHODS From 2006 to January 2011, laparoscopic hepatectomies were performed on 30 cases of HCC at Northern Jiangsu People's Hospital. During this same time period, 30 patients elected to undergo conventional open hepatectomy over laparoscopic hepatectomy at the time of informed consent. The degree of invasiveness and outcomes of laparoscopic hepatectomy compared to open hepatectomy for HCC were evaluated. RESULTS Both groups presented with similar blood loss amounts, operating times and complications. Patients in the laparoscopic hepatectomy group started walking and eating significantly earlier than those in the open hepatectomy group, and these more rapid recoveries allowed for shorter hospitalizations. There were no significant differences between procedures in survival rate. CONCLUSION Laparoscopic hepatectomy is beneficial for patient quality of life if the indications are appropriately based on preoperative liver function and the location and size of the HCC.
Clonal Analysis and Mutations in the PTEN and the K-ras Genes in Endometrial Hyperplasia

The patterns of X chromosome inactivation and mutations of PTEN and K-ras were evaluated in cases of endometrial hyperplasia to determine the presence of potentially premalignant neoplastic versus polyclonal benign cell populations. Endometrial glandular epithelial cells were collected by laser capture microdissection, and genomic DNAs were extracted. Following treatment with the methylation sensitive restriction endonuclease Hha I, polymerase chain reaction amplification was performed targeting a highly polymorphic short tandem repeat of the human androgen receptor gene (HUMARA). PTEN and K-ras gene mutations were evaluated by analysis of single-strand conformation polymorphism. Two pathologists performed histologic diagnosis of the lesions independently. Monoclonal composition was demonstrated in 13 of 15 (87%) endometrial hyperplasias with atypia and 17 of 31 (55%) complex hyperplasias without atypia. Cytological atypia is significantly associated with the clonal status of the endometrial hyperplasia (13/15 vs 17/31, P = 0.049). In contrast, all 14 normal endometrial tissue samples were polyclonal. PTEN gene mutations were detected in 4 of 13 (30%) monoclonal endometrial hyperplasias with atypia and 2 of 17 (12%) monoclonal endometrial hyperplasias without atypia but were not detected in polyclonal endometrial hyperplasias, with or without atypia. K-ras gene mutations were present in 3 of 13 (23%) monoclonal endometrial hyperplasias with atypia but not in 2 cases of polyclonal endometrial hyperplasia with atypia or in 26 cases of endometrial hyperplasia without atypia. K-ras mutation is thus significantly more frequently found in endometrial hyperplasias with atypia than those without atypia (3/15 vs 0/31, P = 0.030). This study indicates that most cases of endometrial hyperplasia with atypia and a high proportion of cases of endometrial hyperplasias without atypia originate from a single progenitor cell, possibly as a result of genetic alterations, rather than as a result of benign reactive processes.
Macrolide resistance testing and molecular subtyping of Treponema pallidum strains from southern Africa

Objectives To determine whether the 23S ribosomal RNA (rRNA) A2058G and A2059G mutations that confer macrolide resistance are present among southern African strains of Treponema pallidum and to determine their subtype distribution. Methods 117 genital ulcer specimens, collected between March 2005 and April 2010 in South Africa and Lesotho and previously determined to be positive for T pallidum DNA by molecular testing, were retested using a commercial real-time PCR assay. Those specimens that were still positive for T pallidum DNA were screened for the macrolide resistance-encoding point mutations in the 23S rRNA gene using rapid PCR-based restriction digest assays. Molecular characterisation of two variable treponemal genes, arp and tpr, was used to subtype the T pallidum strains. Results 1 of 100 T pallidum-positive specimens, collected in Lesotho, contained the A2058G macrolide resistance-encoding 23S rRNA gene mutation, whereas the A2059G mutation was absent. It was possible to fully type 97/100 of all T pallidum DNA-positive samples. A total of nine arp repeat sizes, nine tpr patterns and a combined total of 20 subtypes were identified. Overall, the most common subtypes were 14d (32%), followed by 17d (12%), 14a (10%), 14b (8%), 22b (6%) and 14i (5%). Subtypes 14d and 14a were the predominant subtypes in samples from South Africa (43%) and Lesotho (22%), respectively. Conclusions Macrolide resistance among T pallidum strains appears to be uncommon in southern Africa. Although a high degree of genetic heterogeneity was observed among the strains tested, T pallidum subtype 14d appears to be the predominant circulating strain.
Magnetic Resonance Imaging in the Diagnosis of Disc Degeneration: Correlation with Discography

One hundred and one disc levels in 36 patients with low-back pain were studied with magnetic resonance imaging (MRI) (T2-weighted) sagittal images and conventional roentgenographic discography to detect early disc degeneration. Thirty-nine discs also were evaluated after discography with roentgenographic CT MRI findings were compared with discography results. MRI was 99% accurate in predicting normality or abnormality as determined by discography. Changes in disc signal on MRI accurately reflected the presence or absence of degenerative changes seen on discography in patients with low-back pain. Clinically, MRI is a useful technique for detecting early disc degeneration and for assessing the affected disc level and adjacent levels in patients with low-back pain and spondylolithesis.
Asymmetric macroeconomic volatility in European regions

ABSTRACT Asymmetric macroeconomic volatility in European regions. Spatial Economic Analysis. This paper investigates, on the basis of a theoretical spatial model, the determinants of macroeconomic volatility of per capita gross domestic product (GDP) in a panel of 257 NUTS-2 European regions in 1992–2008, considering positive and negative fluctuations separately. Evidence is found of strong positive spatial dependence, and of considerable asymmetric effects on macroeconomic volatility of sectoral output (its composition and concentration), of composition of aggregate demand, and of other regional/country characteristics. In particular, while public expenditure exerts a stabilizing effect on both types of fluctuations, financial depth amplifies negative fluctuations. Finally, inflation fluctuations and participation in European Monetary Union (EMU) appear to have no effect on macroeconomic volatility.
Mapping of EMG signal to hand grip force at varying wrist angles

Limb loss is a growing problem in Malaysia and the rest of the world due to the increasing number of industrial accidents, diseases and armed conflicts. After a tragic incident resulting in an amputation or paralysis, the disabled individual needs to be assisted with all possible technological means to improve his quality of life. A cybernetic prosthesis is a device which can greatly assist individuals with hand disabilities by enabling them to have some of the hand capabilities of an able bodied individual. The central nervous system which consists of the brain and spine governs hand grip force and hand movement in the human body by spatial and temporal motor unit recruitments. Electromyogram (EMG) is an electrical biological signal that can be measured from the skin surface and consists of the summation of Motor Unit Action Potentials (MUAP). Hand grip strength, wrist extension and wrist flexion are hand functions which result from the forearm muscle activity and are used in a wide range of daily tasks. Extracting hand grip force and wrist angle information from forearm EMG signals is useful to be used as inputs for the control of cybernetic prostheses. By establishing the relationship between forearm EMG and hand grip force/wrist angles, the prosthetic hand can be controlled in a manner that is customized to an amputee's intent. In this research work, a myoelectric interface which consists of an electronic conditioning circuit to measure EMG signals and the software to record and process the EMG signals was developed. Experimental training and testing data sets from five subjects were collected to investigate the relationship between forearm EMG, hand grip force and wrist angle simultaneously.
Pesticins III. Expression of Coagulase and Mechanism of Fibrinolysis

Mutational loss of pesticin I, a bacteriocin-like substance produced by Pasteurella pestis, is known to result in concomitant loss of a coagulase and fibrinolytic factor. No relationship was detected between pesticinogeny and other tested properties either associated with virulence or peculiar to P. pestis. Pesticin I was distinguished from the coagulase and fibrinolytic activities on the basis of anatomical distribution, behavior during gel filtration, and sensitivity to heat. Coagulase and the fibrinolytic factor were not differentiated by these criteria. Spontaneous suppressor mutations causing reversion to pesticinogeny were not detected, nor were such mutants obtained by treatment with ultraviolet light or 2-aminopurine. Attempts to demonstrate a common activator of pesticin I, coagulase, or the fibrinolytic factor in extracts of pesticinogenic cells were not successful. These results are in accord with the hypothesis that at least two structural genes for the three activities reside on a replicon distinct from the chromosome proper. Fibrinolytic activity was significantly reduced in the presence of 0.003 m ε-aminocaproic acid and was nonexistent on fibrin films freed from endogenous plasminogen by treatment with heat. Fibrinolytic activity on heated films could be restored by addition of plasma or serum from six mammalian species. Accordingly, the plague fibrinolytic factor, like staphylokinase or urokinase, promotes the conversion of plasminogen to plasmin.
Changes in the Midbrain‐Rostral Forebrain Dopamine Circuitry in the Cocaine‐Exposed Primate Fetal Brain a

ABSTRACT: To ascertain cocaine's effects in the fetus, we developed a nonhuman primate model in which pregnant monkeys were administered cocaine (3 mg/kg im) or saline four times a day from day 20 through days 40–70 of a 165‐day gestation. At the time of cesarean section, plasma levels of cocaine in fetal blood were 231 ± 70 ng/ml. Fetal brains were examined using immunocytochemistry, in situ hybridization, receptor autoradiography, and nuclease protection assay analysis. No differences were found in the expression of tyrosine hydroxylase and dopamine receptor mRNAs by days 40–45 of gestation. However, by day 60 the midbrain of monkeys exposed to cocaine had significantly reduced expression of tyrosine hydroxylase, the rate‐limiting enzyme in dopamine synthesis. Moreover, dopamine D1 and D2 receptor mRNAs were significantly elevated in the rostral forebrain as were D1 and D2 receptor binding sites in days 60–70 cocaine‐exposed fetuses. Cocaine treatment from day 20 to days 60 and 70 of gestation also significantly increased the mRNA concentrations of dynorphin and enkephalin in the rostral forebrain. These findings suggest that in utero cocaine exposure has profound effects on the developing dopamine neurocircuitry.
The emerging role of community sentinel surveillance in the understanding of the clinical features and epidemiology of acute Mycoplasma pneumoniae infection.

Retrospective analysis of 3984 test results for the detection of Mycoplasma pneumoniae performed between 2009 and 2013 in Wales was undertaken. Analysis of the clinical presentation of positive cases suggested that mild respiratory infection was common in the community and appeared to coincide with increased hospitalizations. Symptomatic infection was more prevalent in men, with a median age of 22.6 years (range <1-88 years), and 40% of hospitalized cases presented with pneumonia. Inclusion of M. pneumonia nucleic acid amplification tests (NAATs) into routine respiratory NAAT screens will increase the understanding of the epidemiology and clinical spectrum of acute infections in the wider population.