Miracle-dz/UniFAR-FTUs huggingface dataset:
Establishment of growth medium and quantification of pollen grains and germination of pear tree cultivars

To support breeding programs of pear tree, on the selection of cultivars to subtropical area in Brazil, the objective of this research was to adjust the growth medium basic to pollen grain germination. The pollen grains of 'D'Agua' cultivar were spread on the surface of Petri dishes containing 20 ml of culture medium in accordance with the following sequential experiments: 1) agar (4; 6; 8 and 10 g L-1) and pH (3,5; 4,5; 5,5 and 6,5); 2) sucrose (0; 30; 60 and 90 g L-1); 3) calcium nitrate (0; 200; 400 and 800 mg L-1); 4) boric acid (0; 400; 800 and 1200 mg L-1); 5) temperature of incubation (15; 20; 25 e 30 oC) and 6) emission time of the pollen tube (0; 1; 2; 3; 4; 5 and 6 hours after inoculation). After incubation, the germination rate of pollen grains of nine pear cultivars ('Rocha', 'Abate Fetel', 'Packham's Triumph', 'Atago', 'Hosui', 'Primorosa', 'Triunfo', 'Seleta' and 'D'Agua') was evaluated, and number of stamens, the number of pollen grains per anther and per flower. The protocol for germination of pollen grains of pear tree consist in the culture medium have to be solidified with 10 g L-1 agar, being the pH measured to 5,2 , added with 90 g L-1 sucrose, 145 mg L-1 calcium nitrate and 700 mg L-1 boric acid, with incubation temperature of 23 oC. The readings germination percentage should be performed after five hours of incubation. The pollen grain 'Rocha' cultivar showed higher germination percentage.
Developmental Changes of Prefrontal Cortex and Cerebro-Cerebellar Functioning in Older Adults: Evidence from Stabilometer and Cognitive Tests

The relation between cognitive and postural functioning was examined as developmental changes among healthy older adults. The 339 participants (207 women and 132 men) of four age groups (50’s, 60’s, 70’s, and 80’s) were given the Digit Cancellation Test (D-CAT) for the assessment of prefrontal cortex related cognitive functioning, and the Logical Memory Test for the assessment of fronto-parietal cortex related cognitive functioning. The postural functioning of the participants was measured by a stabilometer for the assessment of cerebro-cerebellar related motor functioning. The results showed that the developmental changes in performances for non-automatic intentional cognitive and automatic motor postural functioning were not parallel. Cognitive functioning did not show clear sex difference while motor postural functioning showed robust sex difference. Largely, cognitive functioning DCAT and Logical Memory Test showed gradual performance decrease 23-48% for each age group from 50’s to 80’s while robust motor postural functioning performance decreased approximately 60% from 70’s to 80’s in men and approximately 65% from 60’s to 70’s in women. Based upon these findings, characteristics of age-related changes in cerebro-cerebellar brain systems in middle aged and older healthy people are discussed.
Characteristic of lifespan and reproduction period of Succinea putris (L.) (Gastropoda: Styllomatophora)

The purpose of this study was to observe the lifespan, period of reproduction, characteristics of clutches and eggs, duration of embryo development of Succinea putris (L.) reared under laboratory and natural conditions in Lithuania. The lifespan of S. putris under laboratory conditions varies from 13 to 17 months. The period of mating continues from March to September–October in the field, whereas under laboratory conditions it is life-long. The average number of eggs in the clutch is 48 ± 12.11 in natural biotopes and 12.7 ± 6.77 under laboratory conditions. The development of embryos from eggs to juveniles lasts 10–20 days in the first and 30 days in the second laboratory snail generation. The development of juveniles to sexual maturity lasts 10 months under laboratory conditions. The study has shown that laboratory conditions exert an influence on the reproduction, development and growth of S. putris.
Enhanced Convolutional Neural Tangent Kernels

Recent research shows that for training with $\ell_2$ loss, convolutional neural networks (CNNs) whose width (number of channels in convolutional layers) goes to infinity correspond to regression with respect to the CNN Gaussian Process kernel (CNN-GP) if only the last layer is trained, and correspond to regression with respect to the Convolutional Neural Tangent Kernel (CNTK) if all layers are trained. An exact algorithm to compute CNTK (Arora et al., 2019) yielded the finding that classification accuracy of CNTK on CIFAR-10 is within 6-7% of that of that of the corresponding CNN architecture (best figure being around 78%) which is interesting performance for a fixed kernel. Here we show how to significantly enhance the performance of these kernels using two ideas. (1) Modifying the kernel using a new operation called Local Average Pooling (LAP) which preserves efficient computability of the kernel and inherits the spirit of standard data augmentation using pixel shifts. Earlier papers were unable to incorporate naive data augmentation because of the quadratic training cost of kernel regression. This idea is inspired by Global Average Pooling (GAP), which we show for CNN-GP and CNTK is equivalent to full translation data augmentation. (2) Representing the input image using a pre-processing technique proposed by Coates et al. (2011), which uses a single convolutional layer composed of random image patches. On CIFAR-10, the resulting kernel, CNN-GP with LAP and horizontal flip data augmentation, achieves 89% accuracy, matching the performance of AlexNet (Krizhevsky et al., 2012). Note that this is the best such result we know of for a classifier that is not a trained neural network. Similar improvements are obtained for Fashion-MNIST.
Assessment of Stay Green Genotypes of Sunflower for Root Traits under Different Soil Moisture Regimes

Sunflower (Helianthus annuus L.) is one among the most important oil seed crops, ranking second in importance after soybean in the world. The crop belongs to Asteracae/ Compositae family and native to the temperate North America. Because of its moderate cultivation requirements and high oil quality, its acreage has been increased in both developed and developing countries (Skoric, 1992). Its oil is called premium oil because of high percentage of polyunsaturated fatty acids (60%); including oleic acid (16.2%) and linoleic acid (72.5%), which help to control cholesterol in blood (Satyabrata et al., 1988). Sunflower has been successfully cultivated over a widely scattered geographical area in the world. It is a highly cross pollinated crop which is adaptable to a International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 6 Number 11 (2017) pp. 1156-1166 Journal homepage: http://www.ijcmas. com
HER 2-positive metastatic breast cancer Ado-trastuzumab emtansine ( TDM 1 ) : a novel antibody-drug conjugate for the treatment of

Human epidermal growth factor receptor-2 (HER2)-positive breast cancer is an aggressive form of breast cancer associated with poorer prognosis and shortened survival. Primary and acquired resistance to existing HER2-targeted therapies presents a challenge for the management of patients with HER2-positive metastatic breast cancer. Adotrastuzumab emtansine, a drug-antibody conjugate, has shown promising results for patients failing prior treatment with trastuzumab. Ado-trastuzumab emtansine consists of the monoclonal antibody trastuzumab linked to a potent microtubule inhibitor (emtansine), allowing a targeted delivery of chemotherapy to cells that overexpress HER2. Adotrastuzumab emtansine has been approved for use in patients with metastatic breast cancer who have failed prior therapy with trastuzumab and a taxane. Although well-tolerated in clinical trials, thrombocytopenia has been reported and platelet values should be monitored closely. Increased liver enzymes and bilirubin, as well as cardiotoxicity, have also been documented, and recommendations for dose reduction or discontinuation due to these toxicities are available. Clinical trials are currently ongoing to further define the role of ado-trastuzumab emtansine in both the metastatic and early breast cancer settings.
Reviewers ' Comments to the Authors : Reviewer : 1 Comments to the Author [ Q 1 ]

A new unipolar differential logic (UDL) for the large-scale integration of amorphous In-Ga-Zn-O (aIGZO) digital circuits is proposed. Only single-threshold, single-gate, aIGZO thin-film transistors are required. The proposed UDL logic gates are very insensitive to the transistor parameters variations (i.e. threshold voltage, mobility, off-current, subthreshold slope) that are inherently due to the large-area low-temperature fabrication processes and to the operating conditions. To assess the UDL effectiveness, a wide range of parameters variations is considered: thanks to the proposed architecture up to 1.5 ⇥ 10 UDL gates can be integrated with a yield greater than 90%.
of SUMO interactome in yeast Genome-wide bimolecular fluorescence complementation analysis Material Supplemental

Material Supplemental http://genome.cshlp. org/content/suppl/2013/02/15/gr.148346. 112.DC1. html P<P Published online February 12, 2013 in advance of the print journal. Preprint Accepted likely to differ from the final, published version. Peer-reviewed and accepted for publication but not copyedited or typeset; preprint is License Commons Creative . http://creativecommons.org/licenses/by-nc/3.0/ described at as a Creative Commons License (Attribution-NonCommercial 3.0 Unported License), ). After six months, it is available under http://genome.cshlp. org/site/misc/terms.xhtml for the first six months after the full-issue publication date (see This article is distributed exclusively by Cold Spring Harbor Laboratory Press
DJ-1 / Park 7 sensitive Na + / H + exchanger 1 ( NHE 1 ) in CD 4 + T cells † Short title : DJ-1 sensitive NHE 1 in T cells

1 Department of Cardiology, Vascular Medicine & Physiology, Eberhard-Karls-University, Gmelinstrasse 5, D72076 Tübingen, Germany 2 Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu city, Sichuan, 611130, China 3 Institute of Clinical Anatomy and Cell Analysis, Eberhard-Karls-University, Oesterbergstrasse 3, 72074 Tübingen, Germany 4 Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, UHN, 620 University Ave Toronto, M5G 2C1, Canada 5 Institute of Agricultural and Nutritional Sciences, Martin Luther University HalleWittenberg, Von-Danckelmann-Platz 2, 06120 Halle (Saale), Germany Address for correspondence*: Yogesh Singh or Florian Lang, Department of Cardiology, Vascular Medicine & Physiology, Eberhard-Karls-University, Gmelinstr. 5, D72076 Tübingen, Germany, Phone: +49 7071 29-72194, Fax: +49 7071 29-5618, E-Mail: ysinghbt@gmail.com, florian.lang@uni-tuebingen.de
Current smokers are associated with a lower risk of MM andNMSC possibly as a result of detection bias related to lower screening for skin cancer in smokers

Adjusted model is adjusted for age group, body mass index category, ethnicity/race, skin reaction to the sun, Langley exposure, education, physical activity, history of NMSC, history of malignant melanoma, summer sun exposure as a child, summer sun exposure currently, vitamin D, alcohol use, last medical visit within 1 year, any insurance, and income. For melanoma, Cox proportional HR was used as the exact date of diagnosis was ascertained from medical records. For NMSC, subjects self-reported the diagnosis and thus we used logistic regression (OR). CI, Confidence intervals; HR, hazard ratio; NMSC, nonmelanoma skin cancer; OR, odds ratio. J AM ACAD DERMATOL JANUARY 2015 190 Letters
Prediction of equilibrium solubility of CO2 in aqueous alkanolamines using differential evolution algorithm

Design of sour-gas treating processes with alkanolamine solvents requires knowledge of vapor-liquid equilibrium (VLE) of the aqueous acid gas - alkanolamine systems. The modified Clegg-Pitzer equation is used to correlate and predict the vapor-liquid equilibrium of the CO2-MDEA-H2O and CO2-AMP-H2O systems Differential evolution (DE), a computationally stochastic technique, has been used for parameter estimation of the developed model in an effort to predict the VLE of CO2 in aqueous MDEA and AMP solutions with a comparable accuracy to that by using simulated annealing (SA) and deterministic technique like Levenberg-Marquardt (LM), if not better.
Distributional and demographic consequences of Pleistocene climate fluctuations for a marine demersal fish in the north‐eastern Atlantic

Aim The Pleistocene glaciations were the most significant historical event during the evolutionary life span of most extant species. However, little is known about the consequences of these climate changes for the distribution and demography of marine animals of the north‐eastern Atlantic. The present study focuses on the phylogeographic and demographic patterns of the sand goby, Pomatoschistus minutus (Teleostei: Gobiidae), a small marine demersal fish.
identifies gender-specific reprogramming in mice High-resolution DNA methylome analysis of primordial germ cells Material

Material Supplemental http://genome.cshlp. org/content/suppl/2013/02/15/gr.148023. 112.DC1. html References http://genome.cshlp. org/content/23/4/616.full. html#ref-list-1 This article cites 58 articles, 16 of which can be accessed free at: Open Access Open Access option. Genome Research Freely available online through the License Commons Creative . http://creativecommons.org/licenses/by-nc/3.0/ described at a Creative Commons License (Attribution-NonCommercial 3.0 Unported License), as ). After six months, it is available under http://genome.cshlp. org/site/misc/terms.xhtml first six months after the full-issue publication date (see This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the
Astrocyte-Induced Alterations in Arginine and Proline Metabolisms in Motoneurons

Glutamate-induced excitotoxicity is considered as one of the major pathophysiological factors of motoneuron death in amyotrophic lateral sclerosis and other motoneuron diseases. In order to expand our knowledge on mechanisms of glutamate-induced excitotoxicity, the present study proposes to determine the metabolic consequences of glutamate and astrocytes in primary enriched motoneuron culture. Using liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS), we showed that the presence of astrocytes and glutamate profoundly modified the metabolic profile of motoneurons. Our study highlights for the first time that crosstalk between astrocytes and enriched motoneuron culture induced alterations in phenylalanine, tryptophan, purine, arginine, proline, aspartate, and glutamate metabolism in motoneurons. We observed that astrocytes modulate the sensitivity of motoneurons to glutamate, since metabolites altered by glutamate in motoneurons cultured alone were different (except 5-hydroxylysine) from those altered in co-cultured motoneurons. Our findings provide new insight into the metabolic alterations associated to astrocytes and glutamate in motoneurons and provide opportunities to identify novel therapeutic targets.
of Ecosystems and Management Disturbance regimes in coastal British Columbia

What is the dominant disturbance regime in coastal British Columbia? In this literature review, we discuss the relative importance of fire versus canopy gaps as agents of disturbance affecting the structure and dynamics of unmanaged coastal forests in British Columbia. Our analyses focus on the province’s wet coastal temperate rain forests, specifically the Hypermaritime and Very Wet Maritime Coastal Western Hemlock (CWHvh and CWHvm) subzones, and the Wet Hypermaritime and Moist Maritime Mountain Hemlock (MHwh and MHmm) subzones. After reviewing the relationships between disturbance events, disturbance regimes, and stand dynamics, we critically assess the traditional classification of fire regimes in the wet coastal temperate rain forests, in part by differentiating between fire occurrence and mean return intervals. We provide four lines of evidence to reject the traditional view that stand-initiating fire at intervals of 250–350 years was the dominant disturbance regime in the wet coastal temperate rain forests of British Columbia. According to recent field research, historical fires were very infrequent in wet coastal temperate rain forests and were more likely lowand mixed-severity events, rather than stand-initiating fires. As an alternative to fire, we propose that fine-scale gap dynamics is the dominant process explaining the structure and dynamics of most unmanaged stands in the province’s wet coastal temperate rain forests. Improved understanding of the spatial and temporal attributes of disturbance regimes in coastal forests has important implications for sustainable forest management and conservation of biodiversity.
Hydromechanical behaviour of a heterogeneous compacted soil: experimental observations and modelling

The paper describes a theoretical and experimental study of the coupled hydromechanical behaviour of a compacted mixture of bentonite powder and bentonite pellets intended as sealing material in underground repositories for nuclear waste. One of the main advantages of the use of powder/pellets mixtures is the reduction of the compaction effort required to achieve the value of average dry density necessary to attain the required swelling potential. However, the heterogeneous fabric of the material requires special approaches in order to describe adequately its behaviour during hydration. A double porosity formulation is presented to account for the presence of two distinct structural levels in the material. Hydraulic equilibrium between the two porosities is not assumed; instead a water exchange term between them is postulated. The formulation is applied to the modelling of a number of one-dimensional swelling pressure tests performed in the CEA (Commisariat a l'Energie Atomique, France) and CIEMAT (Spain).
Strathmore UNIVERSITY Public Domestic Debt Optimization and the Term Structure of Interest Rates : Dynamic

In this study, Markowitz's mean-variance optimization approach is applied to Kenya's public debt portfolio to identify the optimal domestic debt portfolio. The study first adopts the Dynamic Nelson Siegel model to parameterize the yields only model of the Term Structure of Interest rates in Kenya between March 20 l 0 and October 2014. This is done so as to account for the importance of elaborate interest rate models in incorporating interest rate uncertainty. The expected interest rate cost is estimated based on the yield curve dynamics as established under the Dynamic Nelson Siegel framework. The optimization scheme adopted minimizes interest rate cost and variance of the different bonds across the different maturities subject to the constraints of no short sales, sufficient liquidity and a suHicient p01tion is allocated to long term maturities to cater for long term development projects. The results indicate that the optimized bond portfolio is in favour of medium to long dated bonds in order to reduce the overall risk level.
Dossier : Neurological disorders : Clinical challenges and controversies Long-term Parkinson ’ s disease e Time for optimism

Data on the natural long-term course of Parkinson’s disease (PD) remain sparse. The aim of this study was to describe the evolution of the functional disability and the response to dopaminergic therapy in patients with PD for many years. The files of 47 patients who had been diagnosed with PD more than 13 years previously were reviewed. Mean age at disease onset was 47 9 years, and mean disease duration was 23.5 9.8 years. Levodopa treatment was initially effective in 95% of the patients but the response decreased with time. At the end of the follow-up period, end-stage disease, i.e. Hoehn and Yahr (H&Y) stage 5 was documented in 45% of the patients. In patients with response fluctuations H&Y stage was graded 5 in 53% of patients in the ‘‘off’’ period and in 27% in the ‘‘on’’ period. In patients without response fluctuations H&Y stage was graded 5 in 23% of patients. Two patients had stage 2 disease (minimal disability). In conclusion, PD has a chronic progressive course, although most patients do not reach end-stage disease. The effect of L-dopa treatment decreases over time, but is not lost completely. 2008 Elsevier Masson SAS. All rights reserved.
Critical behavior in light nuclear systems: Experimental aspects

An extensive experimental survey of the features of the disassembly of a small quasi-projectile system with $A \sim$ 36, produced in the reactions of 47 MeV/nucleon $^{40}$Ar + $^{27}$Al, $^{48}$Ti and $^{58}$Ni, has been carried out. Nuclei in the excitation energy range of 1-9 MeV/u have been investigated employing a new method to reconstruct the quasi-projectile source. At an excitation energy $\sim$ 5.6 MeV/nucleon many observables indicate the presence of maximal fluctuations in the de-excitation processes. The fragment topological structure shows that the rank sorted fragments obey Zipf's law at the point of largest fluctuations providing another indication of a liquid gas phase transition. The caloric curve for this system shows a monotonic increase of temperature with excitation energy and no apparent plateau. The temperature at the point of maximal fluctuations is $8.3 \pm 0.5$ MeV. Taking this temperature as the critical temperature and employing the caloric curve information we have extracted the critical exponents $\beta$, $\gamma$ and $\sigma$ from the data. Their values are also consistent with the values of the universality class of the liquid gas phase transition. Taken together, this body of evidence strongly suggests a phase change in an equilibrated mesoscopic system at, or extremely close to, the critical point. Comment: Physical Review C, in press; some discussions about the validity of excitation energy in peripheral collisions have been added; 24 pages and 32 figures; longer abstract in the preprint
The role of tumor necrosis factor-receptors in pregnancy with normal and adverse outcome

Correspondence: Jean Calleja-Agius Department of Anatomy, Faculty of Medicine and Surgery, University of Malta, Tal-Qroqq, MSD 2080, Malta Tel 00356 2169 3041 Fax 00356 2131 9527 email jean.calleja-agius@um.edu. mt Abstract: TNFα receptors, TNF-R1 and TNF-R2, mediate the biological activities of the multifunctional cytokine, tumor necrosis factor alpha, TNFα. These receptors have a central role in human pregnancy. Although each receptor induces distinct intracellular signals, they also have co-operative and overlapping effects. The membrane bound TNF-R1 carries out most of the pro-inflammatory activities of TNFα, especially those that are rapid, while TNF-R2 is involved in the late long-term effects of this cytokine. The soluble forms of these receptors can bind to TNFα, neutralizing its effects. In normal human pregnancy, TNFα receptors are present in the maternal circulation, placenta, amniotic fluid, and coelomic cavity. Changes in TNFα and its receptors are associated with adverse pregnancy outcomes, including miscarriage, preterm labor and preeclampsia. Advances in anti-TNFα therapy may have potential use in the management of complicated pregnancies.