Miracle-dz/UniFAR-FTUs huggingface dataset:
Orthogonally multiplexed orthogonal amplitude modulation family

A family of coherent orthogonally multiplexed orthogonally amplitude-modulated (OMOAM) signals is presented. The OMOAM signal is constituted by orthogonally multiplexing AI component signals, each constructed by a data-chosen group of L orthogonal pulse-amplitude-modulated basis signals. A generalized signal format is proposed to model the OMOAM signal in a unified way that the family contains not only classical orthogonally multiplexed modulations as special embodiments, but also a multitude of new modulations. A generalized optimum receiver for coherently demodulating OMOAM signals is developed and analyzed in terms of the bit error probability for the additive white Gaussian noise channel. The spectral characteristics of the OMOAM signals constructed from various time-limited and band-limited basis sets are studied in terms or the fractional out-of-band power containment. Several general trends of error and spectral performance characteristics are exploited.
Review Intracavitary Radioimmunotherapy to Treat Solid Tumors

Radioimmunotherapy (RIT) potentially is an attractive treatment for radiosensitive early-stage solid tumors and as an adjuvant to cytoreductive surgery. Topical administration of RIT may improve the efficacy because higher local concentrations are achieved. We reviewed the results of locally applied radiolabeled monoclonal antibodies for the treatment of solid tumors. Intracavitary RIT in patients with ovarian cancer and glioma showed improved targeting after local administration, as compared to the intravenous administration. In addition, various studies showed the feasibility of locally applied RIT in these patients. In studies that included patients with small-volume disease, adjuvant RIT in ovarian cancer and glioma showed to be at least as effective as standard therapy. The information about RIT for peritoneal carcinomatosis of colorectal origin is scarce, while results from preclinical data are promising. RIT may be applied for other, relatively unexplored indications. Studies on the application of radiolabeled antibodies in early urothelial cell cancer have been performed, showing that intracavitary RIT may hold a promise. Moreover, in patients with malignant pleural mesothelioma or malignant pleural effusion, RIT may play a role in the palliative treatment. Intracavitary RIT limits toxicity and improves tumor targeting. RIT is more effective in patients with small-volume disease of solid cancers. RIT may have potential for palliation in patients with malignant pleural mesothelioma or malignant pleural effusion. The future of RIT may, therefore, not only be in the inclusion in contemporary multimodality treatment, but also in the expansion to palliative treatment.
MMPI-2 validity scales in child custody evaluations: clinical versus statistical significance.

The MMPI-2 is commonly used in the psychological assessment of parents within child custody evaluations. Due to the interface of mental health practitioners with non-mental-health professionals in the context of child custody cases, careful attention must be paid to the potential misunderstanding or misuse of data from psychological testing. While traditional clinical lore has maintained an expectation of clinically significant defensiveness on the MMPI-2 with this population, the research data does not support this view. Despite empirical findings that identify patterns of elevations on the MMPI-2 validity scales with parents involved in child custody disputes, these patterns have been demonstrated to reach statistical but not clinical significance. That is, MMPI-2 profiles that contain elevations on scales L or K that either invalidate or notably suppress clinical scales are not to be expected in the child custody population. False causal attributions contributing to the potential mischaracterization or loss of important data related to personality functioning within this population are identified and discussed. Potential dangers associated with such false causal attributions are reviewed.
Intermittent Burst-Firing Weak (1 microTesla) Magnetic Fields Reduce Psychometric Depression in Patients Who Sustained Closed Head Injuries: A Replication and Electroencephalographic Validation

14 patients who reported chronic depression more than one year after closed head injuries were exposed to weak (1 microTesla), burst-firing magnetic fields either across the temporal lobes or over the left frontal lobe. The treatment was for 30 min. once per week for 6 wk. The reduction in depression scores after 5 wk. of treatments and after 6 wk. of no treatment (follow-up) accommodated 54% of the variance for both groups. The changes in depression scores did not differ significantly between the two groups (temporal vs frontal). Following treatment, the frequency of complex partial epileptic-like experiences decreased significantly only for the 7 who received the bilateral stimulation over the temporal lobes. Quantitative bipolar electroencephalographic measurements over the occipital, prefrontal, and temporal regions showed increased power within the 16-Hz to 18-Hz range 6 wk. after termination of treatment for those 7 patients who received the burst-firing magnetic fields bilaterally over the temporal lobes but not over the left prefrontal region.
HUMAN CHOLESTERYL ESTER TRANSFER PROTEIN EXPRESSION ENHANCES THE MOUSE SURVIVAL RATE IN AN EXPERIMENTAL SYSTEMIC INFLAMMATION MODEL: A NOVEL ROLE FOR CETP

Mice expressing human cholesteryl ester transfer protein (huCETP) are more resistant to Escherichia coli bacterial wall LPS because death rates 5 days after intraperitoneal inoculation of LPS were higher in wild-type than in huCETP+/− mice, whereas all huCETP+/+ mice remained alive. After LPS inoculation, plasma concentrations of TNF-&agr; and IL-6 increased less in huCETP+/+ than in wild-type mice. LPS in vitro elicited lower TNF-&agr; production by CETP expressing than by wild-type macrophages. In addition, TNF-&agr; production by RAW 264.7 murine macrophages increased on incubation with LPS but decreased in a dose-dependent manner when human CETP was added to the medium. Human CETP in vitro enhanced the LPS binding to plasma high-density lipoprotein/low-density lipoprotein. The liver uptake of intravenous infused 14C-LPS from Salmonella typhimurium was greater in huCETP+/+ than in wild-type mice. Present data indicate for the first time that CETP is an endogenous component involved in the first line of defense against an exacerbated production of proinflammatory mediators.
Rheumatic Aschoff nodules revisited. II: Cytokine expression corroborates recently proposed sequential stages

A recent immunohistochemical analysis of the Aschoff lesions in rheumatic fever, combining immunohistochemical analysis with comparative morphology, permitted the division of the Aschoff nodules into three stages: (1) Aschoff nodule without admixed lymphocytes, (2) Aschoff nodules with a few T lymphocytes, and (3) Aschoff nodules containing many admixed lymphocytes of both B‐ and T‐cell phenotype. It was postulated that the order of progression was from stage 1 with macrophages only, to accumulation of first T lymphocytes (stage 2) and then B lymphocytes (stage 3). This study was undertaken to determine the role and distribution of interleukin 1 (IL‐1), interleukin 2 (IL‐2) and tumour necrosis factor alpha (TNFα) in the various stages of the rheumatic Aschoff nodule to investigate our hypothesis on the progression of these nodules.
Clodronate Combined with a Surfactant (Tween 20) Does Not Improve Osseointegration: A Rabbit Immunohistomorphometric Study

Biphosphonates are compounds that inhibit bone reabsorption mediated by osteoclasts or the progression of periodontal disease independent on the host response to pathogenic bacteria that colonize the tooth surface. The use of biphosphonates in oral implantology is still in the experimental stage. The aim of this study is to evaluate the efficacy of a non-aminobiphosphonate combined with a surfactant to increase the ability of the drug to link to the implant and bone surfaces in the development of osseointegration in rabbits. Smooth titanium implants were devised to be used on rabbit femurs. A topical administration of clodronate combined with the surfactant (Tween 20) at different concentrations was made on the implant surface and in the implant site to increase the bone and implant adhesiveness. Placebo was given to the control group. New Zealand rabbits were used and sacrificed by CO2 after 8 weeks from the implantations. A histologic and histo-morphometric analysis was carried out. Results did not show significant difference between the tests and the placebo groups. Our data are different from other similar studies obtaining statistically significant differences. These differences could depend on the efficacy of the drug used and on the procedure of application of the drug on the implant. This study demonstrates poor efficacy of clodronate applied topically to the implant and implant site during surgery to increase the percentage of osseointegration in the implant. Further studies using different fixation techniques of the drug may be necessary to confirm the present data.
Distinct pigmentation and trophic modes in Beggiatoa from hydrocarbon seeps in the Gulf of Mexico

Bacterial mats, which are comprised of spatially distinct, pigmented and non-pigmented filamentous Beggiatoa, are abundant at hydrocarbon seeps on the continental slope of the northern Gulf of Mexico. Samples of both filament types were collected, using the submarine 'Johnson Sea Link', from seeps at water depths of ~550 m. The water-soluble pigment of colored strains was inter- nal to the cells and had an absorbance peak of approximately 390 nm. Sulfur granules in both pig- mented and non-pigmented cells indicated that these Beggiatoa had the capability of oxidizing H2S. Non-pigmented filaments were capable of significant CO2 fixation based on incorporation of CO2 by whole, live cells and ribulose-1, 5-bisphosphate carboxylase/oxygenase (RuBisCO) assays using cell-free extracts. RuBisCO activities for extracts from non-pigmented cells ranged from 9.92 to 135.35 nmol CO2 fixed mg protein -1 min -1 . Activities varied significantly with temperature and pH. This ability to use CO2 as the primary carbon source, along with the ability to oxidize H2S for energy, suggests that these non-pigmented filaments were chemoautotrophic. Pigmented filaments, in contrast, had little CO2 incorporation ability. RuBisCO activities from pigmented mats ranged from 0.17 to 0.92 nmol CO2 fixed mg protein -1 min -1 . These results suggest that geochemical processes at hydrocarbon seeps create an environment capable of supporting separate chemoautotrophic and heterotrophic (presumably organo-heterotrophic) Beggiatoa populations.
Randomized, double‐blind study of pramipexole with placebo and bromocriptine in advanced Parkinson's disease

We compared the efficacy and safety of pramipexole (PPX) with placebo in the treatment of advanced Parkinson's disease (PD) as an adjunct to levodopa. A bromocriptine (BR) group was included to enable determination of the noninferiority of PPX relative to BR as the standard treatment. © 2003 Movement Disorder Society
X-ray diffraction: a powerful method of characterizing nanomaterials

X-ray diffraction techniques are a very useful characterization tool to study, non-destructively, the crystallographic structure, chemical composition and physical properties of materials and thin films. It can also be used to measure various structural properties of these crystalline phases such as strain, grain size, phase composition, and defect structure. XRD is also used to determine the thickness of thin films, as well as the atomic arrangements in amorphous materials such as polymers. This paper reports the importance of X-ray diffraction technique for the characterization of nanomaterials.
Reduction of anterior shoulder dislocation in emergency department; is entonox(®) effective?

INTRODUCTION An appropriate procedural sedation and analgesia (PSA) is crucial to reduce a dislocated shoulder successfully in emergency department. This study compares sedative effect of inhalational Entonox(®) (En) to intra-venous (IV) Midazolam plus Fentanyl (F+M). METHODS 120 patients with recurrent anterior shoulder dislocation were randomly assigned into two groups. 60 patients (group F+M) received 0.1 mg/kg IV Midazolam plus 3µg/kg IV Fentanyl and 60 patients (group En) received Entonox(®) with self administration face mask on an on-demand basis. Traction/counter-traction method was used to reduce the dislocated shoulder joint in both groups. RESULTS 48 out of 60 (80%) patients in group F+M and 6 out of 60 (10%) patients in group En had successful reduction (p < 0.0001). The mean pain score reduction was 6.3 ± 1.2 for group F+M and 3 ± 0.9 for group En (p < 0.0001). There was a statistically significant difference in mean patient satisfaction (assessed with Likert score) between two groups (4.45 ± 0.6 for group F+M and 2.3 ± 1 for group En; p < 0.0001). Duration of entire procedure (since the beginning of PSA up to the end of successful or unsuccessful reduction) was shorter in Group F+M, but successful reductions occurred earlier in group En. No major side effect such as airway compromise, retracted respiratory depression, or circulatory failure was occurred in any group. CONCLUSION Entonox(®) may not be an appropriate agent to help reducing a dislocated shoulder.
A Warning About The Drawing of Wrong Conclusions From a Failure to Reproduce Other Researchers' Findings.

1. Gürkov R. Menière and friends: Imaging and classification of hydropic ear disease. Otol Neurotol 2017;38:e539–44. 2. Nakashima T, Naganawa S, Sugiura M, et al. Visualization of endolymphatic hydrops in patients with Meniere’s disease. Laryngoscope 2007;117:415–20. 3. Eliezer M, Gillibert A, Tropres I, Krainik A, Attyé A. Influence of inversion time on endolymphatic hydrops evaluation in 3D-FLAIR imaging. J Neuroradiol 2017;44:339–43. 4. Attyé A, Dumas G, Troprès I, et al. Recurrent peripheral vestibulopathy: Is MRI useful for the diagnosis of endolymphatic hydrops in clinical practice? Eur Radiol 2015;25:3043–9. 5. Nakashima T, Naganawa S, Pyykko I, et al. Grading of endolymphatic hydrops using magnetic resonance imaging. Acta Otolaryngol Suppl 2009;129:5–8. 6. Attyé A, Eliezer M, Boudiaf N, et al. MRI of endolymphatic hydrops in patients with Meniere’s disease: A case-controlled study with a simplified classification based on saccular morphology. Eur Radiol 2016;27:3138–46. 7. Morita N, Kariya S, Farajzadeh Deroee A, et al. Membranous labyrinth volumes in normal ears and Ménière disease: A three-dimensional reconstruction study. Laryngoscope 2009;119: 2216–20. 8. Pender DJ. Membrane stress in the human labyrinth and Meniere disease: A model analysis. Int Arch Otorhinolaryngol 2015;19: 336–42. 9. Pender DJ. Endolymphatic hydrops and Ménière’s disease: A lesion meta-analysis. J Laryngol Otol 2014;128:859–65.
The thematic apperception test.

Imagine that you get such certain awesome experience and knowledge by only reading a book. How can? It seems to be greater when a book can be the best thing to discover. Books now will appear in printed and soft file collection. One of them is this book thematic apperception test. It is so usual with the printed books. However, many people sometimes have no space to bring the book for them; this is why they can't read the book wherever they want.
Ankle motor skill is intact in spinal cord injury, unlike stroke

Background: After an incomplete spinal cord injury (iSCI) or stroke, the impairment of both muscle strength and accurate muscle coordination (timing and amplitude) is an expected clinical finding, although these aspects are not well-distinguished by clinical tests. The objective was to determine whether iSCI patients with impaired corticospinal tract function (reduced strength and prolonged transcranial magnetic stimulation latencies) experience a similar deterioration in muscle coordination as stroke patients. Methods: We assessed ankle dorsal and plantar flexion strength, as well as the ability to accurately control the activation of these muscle groups, using a visuomotor torque tracking task. The task was adjusted to the level of muscle weakness, which enabled a distinction between impairment in strength and coordination to be made. Results: Reference strength and visuomotor task performance values were obtained in 47 healthy subjects. In 27 iSCI patients with significant muscle weakness (ankle dorsal flexion 65% of healthy values, plantar flexion 76%), task performance improved at a similar rate and the final performance level equaled that of healthy subjects. However, in 10 stroke subjects the tracking task performance was significantly impaired in both legs, while strength was mainly reduced in the affected leg. Conclusions: These findings indicate that strength is predominantly affected in incomplete spinal cord injury (iSCI) patients, while accurate muscle activation remains largely unaffected. In stroke patients, muscle coordination deteriorates in both legs, independent of muscle weakness. Therefore, iSCI patients might benefit more from rehabilitation interventions that improve muscle strength than stroke patients, where supraspinal areas involved in motor control are additionally affected.
Estimating the ability of gamblers to detect differences in the payback percentages of reel slot machines: a closer look at the slot player experience.

The results of play on 60 different computer simulated reel slots challenge the widely held theory that frequent slot players are able to detect changes in a slot machine’s house advantage as slight as 1 to 2%. These findings affect the formulation of critical and capital-intensive customer retention strategies and brand positioning campaigns within the gaming industry. An overwhelming majority of 10,000 virtual players were not able to reject the hypothesis of equal payback percentages after playing both a 3% game and a 12% game (i.e., a 400% increase in the house advantage). This result held across three levels of pay table variance and five levels of trials or spins. The differences in house advantages examined herein ranged from 33% to 400%, across the various 2-game comparisons. The results also fail to support those who argue or fear that frequent slot players are able to detect changes in the house advantage over time. Profits from slot operations are critical to the success of most casino resorts, making this research into the slot player experience a valuable contribution to both the literature and casino management.
Atomic structures of the 30S subunit and its complexes with ligands and antibiotics.

The two subunits that make up the ribosome have both distinct and cooperative functions. The 30S ribosomal subunit binds messenger RNA (mRNA) and is involved in the selection of cognate transfer RNA (tRNA) by monitoring codon–anticodon base-pairing during the decoding process. The 50S subunit catalyzes peptide-bond formation. Both subunits work in concert to move tRNAs and mRNAs relative to the ribosome in translocation, and both are the target of a large number of naturally occurring antibiotics. Thus, useful information about the mechanism of translation can be gleaned from structures of both individual subunits and the intact ribosome. In this paper, we describe our work on the determination of the atomic structure of the 30S ribosomal subunit and its complexes with RNA ligands, antibiotics, and initiation factor IF1. The results provide structural insights into how the ribosome recognizes cognate tRNA and discriminates against near-cognate tRNA. They also provide a structural basis for understanding the action of various antibiotics that target the 30S subunit. Knowledge of the atomic structure of the 30S is the culmination of decades of work on its structure and function. The state of the ribosome field two years ago has been summarized in a recent book (Garrett et al. 2000). The initial breakthrough in the goal toward a crystal structure of the ribosome was the crystallization of 50S subunits suitable for diffraction studies by Yonath and coworkers (Yonath et al. 1980). Although these original crystals did not diffract very well, over the course of several years, improved crystals of the 50S subunit were obtained that eventually resulted in diffraction to 3 Å resolution (von Böhlen et al. 1991). Another important advance was the introduction of cryocrystallography to facilitate data collection (Garman and Schneider 1997). Following the demonstration by Hope that cryocrystallography could significantly reduce radiation damage on various proteins (Hope 1988), Hope, Yonath, and coworkers showed that it also reduced damage to ribosome crystals (Hope et al. 1989). Even if better crystals had been obtained in the early 1980s, the technology available then was insufficient to determine the structure of a ribosomal subunit to high resolution. Important developments in synchrotron X-ray sources, instrumentation, and computation (Helliwell 1998; Hendrickson 2000) were all essential for the current progress. CRYSTALLIZATION OF THE 30S SUBUNIT
A spliced Epstein‐Barr virus gene expressed in immortalized lymphocytes is created by circularization of the linear viral genome.

Epstein‐Barr virus (EBV) immortalizes B‐lymphocytes efficiently in vitro and in most or all of the cells a latent infection is established. Only a few viral genes are expressed during latency and these apparently maintain cell immortalization by EBV. A 1.9 kb cDNA clone of an EBV mRNA has been isolated from a B95‐8 cDNA library and this cDNA corresponds to a new member of the group of EBV latent cycle genes. On Northern blots two polyadenylated transcripts 1.7 and 2.0 kb in length have been detected by the cDNA clone in B95‐8 cells as well as in latently infected cell lines and in various cell lines derived from Burkitt's lymphomas. The cDNA sequence showed that this gene consists of nine exons and showed that this gene consists of nine exons and that the transcription unit crosses the terminal repeats. Thus, the intact gene is created upon infection by the circularization of the linear viral DNA molecule at the terminal repeats. One major open reading frame is present in the cDNA apparently coding for a 53 kd protein. A strongly hydrophilic part of the protein is followed by a very hydrophobic C‐terminus, perhaps suggesting a membrane protein. The gene is unrelated to the other latent cycle genes, the EBV nuclear antigens (EBNA 1‐4), the leader protein (LP), and the latent membrane protein (LMP) genes. This is the first example of a viral gene whose coding sequence is only created by joining of the ends of a linear virus.
A chemical study of uterine fluid and blood serum of normal cows during the oestrous cycle.

Chemical analyses were conducted on uterine fluid and blood serum collected from eighty-eight normal adult dairy cows during various days of the oestrous cycle. Uterine fluid contained higher concentrations of reducing substances, potassium, inorganic phosphate and alkaline and acid phosphatase activity than blood serum while levels of calcium and sodium were higher in blood serum than in uterine fluid, supporting the concept that bovine uterine fluid is a product of active secretion and not of simple diffusion from the blood. Concentrations of reducing substances, total protein, potassium, chloride, inorganic phosphate and alkaline and acid phosphatase activity in bovine uterine fluid were all found to vary with the stage of the oestrous cycle, indicating that, in the case of these substances at least, secretion into the uterine lumen is under hormonal control. The level ofalkaline phosphatase in the blood serum was also found to vary with the stage of the oestrous cycle.