Miracle-dz/UniFAR-FTUs huggingface dataset:
Organic cation transporter 3: Keeping the brake on extracellular serotonin in serotonin-transporter-deficient mice

Mood disorders cause much suffering and are the single greatest cause of lost productivity worldwide. Although multiple medications, along with behavioral therapies, have proven effective for some individuals, millions of people lack an effective therapeutic option. A common serotonin (5-HT) transporter (5-HTT/SERT, SLC6A4) polymorphism is believed to confer lower 5-HTT expression in vivo and elevates risk for multiple mood disorders including anxiety, alcoholism, and major depression. Importantly, this variant is also associated with reduced responsiveness to selective 5-HT reuptake inhibitor antidepressants. We hypothesized that a reduced antidepressant response in individuals with a constitutive reduction in 5-HTT expression could arise because of the compensatory expression of other genes that inactivate 5-HT in the brain. A functionally upregulated alternate transporter for 5-HT may prevent extracellular 5-HT from rising to levels sufficiently high enough to trigger the adaptive neurochemical events necessary for therapeutic benefit. Here we demonstrate that expression of the organic cation transporter type 3 (OCT3, SLC22A3), which also transports 5-HT, is upregulated in the brains of mice with constitutively reduced 5-HTT expression. Moreover, the OCT blocker decynium-22 diminishes 5-HT clearance and exerts antidepressant-like effects in these mice but not in WT animals. OCT3 may be an important transporter mediating serotonergic signaling when 5-HTT expression or function is compromised.
Inhibition of coral recruitment by macroalgae and cyanobacteria

Coral recruitment is a key process in the maintenance and recovery of coral reef eco- systems. While intense competition between coral and algae is often assumed on reefs that have undergone phase shifts from coral to algal dominance, data examining the competitive interactions involved, particularly during the larval and immediate post-settlement stage, are scarce. Using a series of field and outdoor seawater table experiments, we tested the hypothesis that common species of macroalgae and cyanobacteria inhibit coral recruitment. We examined the effects of Lyngbya spp. , Dictyota spp. , Lobophora variegata (J. V. Lamouroux) Womersley, and Chondrophycus poiteaui (J. V. Lamouroux) Nam (formerly Laurencia poiteaui) on the recruitment success of Porites astreoides lar- vae. All species but C. poiteaui caused either recruitment inhibition or avoidance behavior in P. astreoides larvae, while L. confervoides and D. menstrualis significantly increased mortality rates of P. astreoides recruits. We also tested the effect of some of these macrophytes on larvae of the gorgon- ian octocoral Briareum asbestinum. Exposure to Lyngbya majuscula reduced survival and recruit- ment in the octocoral larvae. Our results provide evidence that algae and cyanobacteria use tactics beyond space occupation to inhibit coral recruitment. On reefs experiencing phase shifts or tempo- rary algal blooms, the restocking of adult coral populations may be slowed due to recruitment inhibi- tion, thereby perpetuating reduced coral cover and limiting coral community recovery.
ERP institutionalization: exploring the influential factors

– The purpose of this paper is to investigate the external and internal factors that contribute to assimilation of enterprise resource planning (ERP) system in the organization through the processes of adapting, routinizing and institutionalization of technology. , – This research follows qualitative interpretive approach. The results produced in this paper are based on thematic analysis of responses from open-ended interviews with ERP stakeholders in large size Australian organizations. The research findings have been further triangulated with surveys and content analysis. , – This research is still in progress; therefore, this paper presents the results of the field study conducted so far along with the instrument used to collect data. This instrument consists of a list of selected questions based on the thorough review of current information systems literature. However, the major finding of this study, thus far, is that the ERP implementation is a process of aligning technology with organizational, social, cultural, economic, technical, and other organizational environmental institutions. , – The major research limitation of this study is that it is still in progress, therefore, the results reported in this paper are emergent and not complete. Another limitation of this paper is that it is Australian specific; therefore, the generalizability of the results in other settings cannot be ascertained. Nevertheless, this research contributes to the ERP implementation literature by applying a stage-based model which takes into account the pre-implementation, implementation and post-implementation stages of ERP assimilation into an integrated structure. , – This research concludes that ERP assimilation is characterized and shaped by mutual interactions of various organizational, social, cultural, environmental, and other institutional factors. The research framework developed in this study may be mastered as a decision-making tool by business manager to guide the organization through various stages of ERP institutionalization. , – Institutionalization of ERP technologies is a recent phenomenon and this field is far for being matured. This research is based in Australian settings where they have been no previous study of institutionalization of technology.
Deep Learning Models for Wireless Signal Classification With Distributed Low-Cost Spectrum Sensors

This paper looks into the modulation classification problem for a distributed wireless spectrum sensing network. First, a new data-driven model for automatic modulation classification based on long short term memory (LSTM) is proposed. The model learns from the time domain amplitude and phase information of the modulation schemes present in the training data without requiring expert features like higher order cyclic moments. Analyses show that the proposed model yields an average classification accuracy of close to 90% at varying signal-to-noise ratio conditions ranging from 0 dB to 20 dB. Further, we explore the utility of this LSTM model for a variable symbol rate scenario. We show that a LSTM based model can learn good representations of variable length time domain sequences, which is useful in classifying modulation signals with different symbol rates. The achieved accuracy of 75% on an input sample length of 64 for which it was not trained, substantiates the representation power of the model. To reduce the data communication overhead from distributed sensors, the feasibility of classification using averaged magnitude spectrum data and on-line classification on the low-cost spectrum sensors are studied. Furthermore, quantized realizations of the proposed models are analyzed for deployment on sensors with low processing power.
The Accuracy of Fit of Crowns Made From Wax Patterns Produced Conventionally (Hand Formed) and Via CAD/CAM Technology.

OBJECTIVE The aim of this study was to compare the marginal and internal fit accuracy of crowns constructed using three different wax production methods; conventional, milled, and 3D printed and utilizing three different cement gap thicknesses. METHODS 15 identical stone dies were made for each method. Wax patterns were produced and then cast into metal crowns, which were assessed for differences in accuracy of both marginal and internal fit. Measurement points were 4 points per crown; occlusal, axial, marginal gap, and marginal discrepancy points. A silicone impression technique and conventional cementation technique were employed to facilitate the measurements. RESULTS There was no significant difference (p > 0.05) in accuracy between the digitally and manually produced crowns, with the 3D printed crowns being slightly more accurate. Whereas, statistically significant differences were noticed between the conventional versus printed groups, in occlusal and marginal gap points (p < 0.05). CONCLUSION The marginal and internal fit of 3D printed wax patterns is more accurate than the other two production methods. The milling of wax crowns is as accurate as the conventional hand carved production in terms of internal and marginal fit. The manufacturer recommended offset/die-spacer of 30 μm produced the most accurate internal and marginal fits.
[Needs of parents with premature newborns in the Neonatal Intensive Care Unit: parents' and nurses' perceptions].

UNLABELLED The aim of the study was to compare parents' and nurses' perceptions of parents' needs in the neonatal intensive care unit. MATERIAL AND METHODS The study was conducted in the Kaunas Perinatal Center, Neonatal Intensive Care Unit, Hospital of Kaunas University of Medicine. The sample consisted of 181 parents and 37 nurses. The NICU Family Needs Inventory was used for data collection. The instrument included the following five dimensions (subscales) of needs: proximity, information, assurance, support, and comfort. Reliability of the scale was identified as 0.94 using Cronbach's alpha. RESULTS The parents' needs perceived by both the groups were compared within the subscales. Using the Mann-Whitney rank test, the significant differences between the parents' and nurses' assessments of individual statements were identified. The majority of statistically significant differences between parents and nurses have been found assessing the proximity (75.0%) and informational (72.7%) needs related to the possibility for parents to be close to their newborns and to receive timely and adequate information about their newborns' health condition. Parents, if compared to nurses, rated these needs as more important. The assessment of support needs showed the lowest number of differences (38.9%). There was a statistically significant difference assessing the support in decision-making related to the newborn care, which was identified by parents as being more important. Nurses perceived the needs related to parent-to-parent support and possibility to share feelings as being more important. CONCLUSION The comparison of parents' and nurses' perceptions of parents' needs in the neonatal intensive care unit showed that there are statistically significant differences in the assessment of individual statements within all five subscales.
The effects of medication and symptom management education program based on self efficacy theory for the psychiatric patients.

PURPOSE An effective rehabilitation program had been developed for psychiatric patients' self management of medication and symptoms in Korea. The rehabilitation program was designed to allow the patients to understand their illness, cope with their medical regimen, and prevent a relapse by recognizing any of the symptoms when they recur. METHODS The developed program utilizes the self efficacy method reported by Bandura, it includes manuals and videotapes focusing on real life situations, small group discussions, and telephone coaching. This study investigated the effects of this program with respect to various predictable variables in psychiatric rehabilitation. Thirty eight patients were selected for this study, 18 in the experimental program and 20 as controls. RESULTS The results showed that the subjects who attended this educational program reported significantly more improvement in attitude toward medication compliance (p=0.033), and significantly less relapse warning symptom scores (p=0.000) than the controls. CONCLUSION This program may be a useful psychoeducational resource for professionals in the field of clinical practice in psychiatry.
High temperature vibration energy harvester system

This work presents the first demonstration of a high temperature piezoelectric energy harvester system, capable of operation up to 300°C. The system comprises of a PZT piezoelectric energy harvester with a silicon carbide Schottky diode full wave rectifier, which can rectify the AC supplied by the piezoelectric harvester at higher temperatures than conventional silicon components. When the harvester is driven at 400mg (3.9ms−2), into a matched load, the rectifier delivers 320µW at room temperature, falling to 80µW at 300°C. This is caused by a combination of increased mechanical damping, decreased electromechanical coupling coefficient (Ksys2) and an increase in the dielectric constant of the PZT.
The Effect of Mobile Gamification on Brand Loyalty

Gamification is defined as using game design elements, characteristic for games, in non-game contexts, and it is a process of using game mechanics to engage users and achieve a specific goal. In order to build effective gamification apps (applications) for effective user performance, the objectives of this project is to develop strategic elements for mobile gaming design in providing innovative services. The purpose of this study is mainly to use the Gamification concept to design a mobile gaming app (application) for contextual marketing, and we were integrate digital game design technologies, such as mobile augmented reality (MAR) and global positioning system (GPS). This study was then look at associated consumer value and brand loyalty created by the users after experiencing the mobile game. Accordingly, we define the eight elements of a mobile gamification design, including coping-escape, fantasy, recreation, social, omnipotence, competition, skill development, and location-based. This research model treats “location-based” as a formative second-order construct driven by ubiquitous connectivity and contextual offer. Consumer value is also a formative second-order construct driven by utilitarian value, hedonic value and social value. Brand loyalty is a reflective second-order construct driven by continuance intention and word-of-mouth. This study was conduct a quasi-experimental research to verify our model. It is hoped that service managers can benefit from the insights discovered from this study and implement more effective management strategies for effective performance.
Human T-Cell Lymphotropic Virus Type 1 Open Reading Frame II-Encoded p30II Is Required for In Vivo Replication: Evidence of In Vivo Reversion

ABSTRACT Human T-cell lymphotropic virus type 1 (HTLV-1) causes adult T-cell leukemia/lymphoma and exhibits high genetic stability in vivo. HTLV-1 contains four open reading frames (ORFs) in its pX region. ORF II encodes two proteins, p30II and p13II, both of which are incompletely characterized. p30II localizes to the nucleus or nucleolus and has distant homology to the transcription factors Oct-1, Pit-1, and POU-M1. In vitro studies have demonstrated that at low concentrations, p30II differentially regulates cellular and viral promoters through an interaction with CREB binding protein/p300. To determine the in vivo significance of p30II, we inoculated rabbits with cell lines expressing either a wild-type clone of HTLV-1 (ACH.1) or a clone containing a mutation in ORF II, which eliminated wild-type p30II expression (ACH.30.1). ACH.1-inoculated rabbits maintained higher HTLV-1-specific antibody titers than ACH.30. 1-inoculated rabbits, and all ACH.1-inoculated rabbits were seropositive for HTLV-1, whereas only two of six ACH.30. 1-inoculated rabbits were seropositive. Provirus could be consistently PCR amplified from peripheral blood mononuclear cell (PBMC) DNA in all ACH.1-inoculated rabbits but in only three of six ACH.30. 1-inoculated rabbits. Quantitative competitive PCR indicated higher PBMC proviral loads in ACH.1-inoculated rabbits. Interestingly, sequencing of ORF II from PBMC of provirus-positive ACH.30. 1-inoculated rabbits revealed a reversion to wild-type sequence with evidence of early coexistence of mutant and wild-type sequence. Our data provide evidence that HTLV-1 must maintain its key accessory genes to survive in vivo and that in vivo pressures select for maintenance of wild-type ORF II gene products during the early course of infection.
Cognitive decline in multiple sclerosis: impact of topographic lesion distribution on differential cognitive deficit patterns

Background: Multiple sclerosis (MS) is often accompanied by cognitive dysfunction. A negative correlation between cerebral lesion load and atrophy and cognitive performance has been pointed out almost consistently. Further, the distribution of lesions might be critical for the emergence of specific patterns of cognitive deficits. Objective: The current study evaluated the significance of total lesion area (TLA) and central atrophy for the prediction of general cognitive dysfunction and tested for a correspondence between lesion topography and specific cognitive deficit patterns. Methods: Thirty-seven patients with MS underwent neuropsychological assessment and magnetic resonance imaging. Lesion burden and central atrophy were quantified. Patients were classified into three groups by means of individual lesion topography (punctiform lesions/periventricular lesions/confluencing lesions in both periventricular and extra-periventricular regions). Results: TLA was significantly related to 7 cognitive variables, whereas third ventricle width was significantly associated with 20 cognitive parameters. The three groups differed significantly in their performances on tasks concerning alertness, mental speed, and memory function. Conclusion: Third ventricle width as a straight-forward measure of central atrophy proved to be of substantial predictive value for cognitive dysfunction, whereas total lesion load played only a minor role. Periventricular located lesions were significantly related to decreased psychomotor speed, whereas equally distributed cerebral lesion load did not. These findings support the idea that periventricular lesions have a determinant impact on cognition in patients with MS.
Bone turnover markers and bone mineral density response with risedronate therapy: Relationship with fracture risk and patient adherence

Surrogate markers of fracture risk—bone turnover markers (BTMs) and bone mineral density (BMD)—can be used to monitor treatment response. We assessed whether changes in these markers greater than the least significant change (LSC) were associated with fracture risk reduction and greater adherence. This secondary analysis of the Improving Measurements of Persistence on ACtonel Treatment (IMPACT) study—a multinational prospective, open‐label, cluster‐randomized study of postmenopausal women on oral risedronate 5 mg/d for 52 weeks—assessed adherence by electronic monitors. Urinary N‐terminal cross‐linked telopeptide of type 1 collagen (uNTX) and serum C‐terminal cross‐linked telopeptide of type 1 collagen (sCTX) levels were assessed at baseline and weeks 10 and 22, and BMD at baseline and week 52. Fractures were recorded as adverse events. In 2302 women, responses beyond LSC in BTMs (uNTX and sCTX) and BMD (spine only) were associated with a reduced risk of nonvertebral fractures (NVFs) and all fractures. NVF incidence was about 50% lower in patients with 30% or more of uNTX reduction at week 22 (1.6%) than in those with less than 30% reduction (3.2%, p = .015). NVFs also were reduced in patients with more than 3% spine BMD increase at 52 weeks than those with 3% or less. Responses greater than LSC in BTMs and BMD were associated with greater adherence, but there was no association between adherence and fracture outcomes at 52 weeks. Changes greater than the LSC in BTMs and BMD reflect better treatment adherence, were associated with fracture risk reduction, and identify differences in individual responsiveness to risedronate. © 2011 American Society for Bone and Mineral Research.
Quantitative genetic parameters for wild stream‐living brown trout: heritability and parental effects

Adaptability depends on the presence of additive genetic variance for important traits. Yet few estimates of additive genetic variance and heritability are available for wild populations, particularly so for fishes. Here, we estimate heritability of length‐at‐age for wild‐living brown trout (Salmo trutta), based on long‐term mark‐recapture data and pedigree reconstruction based on large‐scale genotyping at 15 microsatellite loci. We also tested for the presence of maternal and paternal effects using a Bayesian version of the Animal model. Heritability varied between 0.16 and 0.31, with reasonable narrow confidence bands, and the total phenotypic variance increased with age. When introducing dam as an additional random effect (accounting for c. 7% of total phenotypic variance), the level of additive genetic variance and heritability decreased (0.12–0.21). Parental size (both for sires and for dams) positively influenced length‐at‐age for juvenile trout – either through direct parental effects or through genotype‐environment correlations. Length‐at‐age is a complex trait reflecting the effects of a number of physiological, behavioural and ecological processes. Our data show that fitness‐related traits such as length‐at‐age can retain high levels of additive genetic variance even when total phenotypic variance is high.
Current practice of abdominal fascial closure: a survey of Ontario general surgeons.

OBJECTIVES To determine the current practice of abdominal fascial closure among provincial general surgeons. The primary objective was to determine the proportion of surgeons choosing absorbable versus nonabsorbable sutures. Secondary objectives included determining knowledge and attitudes of surgeons to evidence-based medicine and concordance of current practice with level I evidence. DESIGN A survey. SETTING The province of Ontario. PARTICIPANTS One hundred general surgeons. METHODS A stratified random sample of community and academic surgeons was assembled and a questionnaire was mailed to them. Common clinical scenarios and questions pertaining to attitudes and knowledge of evidence-based medicine were included. MAIN OUTCOME MEASURES Use of absorbable versus nonabsorbable suture material. Willingness to change current practice on evidence-based level I reports. RESULTS Most surgeons (86%) chose an absorbable suture for abdominal fascial closure. Nonabsorbable suture was chosen by 58% of surgeons in the highly contaminated surgical scenario. Eighty-one percent of surgeons indicated they would be willing to change their current practice of fascial closure if there was evidence that the incidence of wound complications was reduced. Polyglactin (Vicryl) was the most commonly chosen suture. CONCLUSIONS The current practice of abdominal fascial closure among Ontario general surgeons is in disagreement with the findings from a recent meta-analysis, recommending a nonabsorbable suture for a 32% relative risk reduction in the incisional hernia rate. The majority of surgeons employ a continuous absorbable closure in common surgical scenarios. A definitive randomized controlled trial comparing continuous nonabsorbable closure versus continuous absorbable closure is warranted.