Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessing London, Ontario's brownfield redevelopment effort to promote urban intensification

Intensification of existing urban areas is currently a major item on the policy agenda of the Ontario and Canadian governments. As part of the urban intensification drive, brownfield sites have become major candidates for redevelopment. Governments at all levels have initiated policies and programmes to encourage their remediation and redevelopment. This paper reports the findings of a qualitative exploration of brownfield redevelopment in London, Canada. Through in-depth interviews (n = 17) with key stakeholders involved in brownfield redevelopment, the study explores the level of participation in brownfield redevelopment, barriers to brownfield redevelopment in the city, and perceptions about financial incentives in the city's Brownfield Community Improvement Plan. The study found that despite the availability of financial incentives, the overall private sector participation in brownfield redevelopment is low due to barriers such as competition from greenfield, risk, cost, negative public perception of brownfields, and complex remediation processes. The paper provides policy suggestions that may contribute to a more active participation in brownfield redevelopment in the city.
Estrogen and Progesterone Receptor Expression and its Correlation with Various Clinicopathological Parameters in Ovarian Tumors

Background : This study evaluates estrogen and progesterone expressions in patients with ovarian tumors (both benign and malignant) and their correlation with various clinicopathological prognostic parameters. Receptors for estrogen and progesterone are predictive and prognostic markers of endometrial and breast cancers. However, their clinical significance in epithelial ovarian cancer is not clear due to conflicting data from only a few immunohistochemical studies available in the literature. Methods : The present study was conducted on 60 cases of ovarian tumors, 20 benign and 40 malignant. Estrogen and progesterone expressions were studied by immuno- histochemistry and correlated with various clinicopathological parameters such as, menopausal status, histological type, WHO grade and FIGO stage. Results : Out of 20 benign tumors the estrogen receptor was positive in 10 (50%) and progesterone receptor was positive in 14 (70%) tumors. In 40 malignant tumors, the estrogen receptor was positive in 13 (32.5%) and progesterone receptor was positive in 11 (27.5%) cases. There was statistically significant estrogen receptor expression observed in serous tumors (P=0.001). When compared with other clinico- pathological parameters, we noted a significant association between progesterone receptor expression and favorable prognostic parameters such as young age, benign tumors and early FIGO stage. Conclusion : There were variable expressions of the estrogen and progesterone receptors in ovarian tumors. Progesterone receptor expression was associated with favorable prognostic factors that included younger age, benign tumor and low FIGO stage. No such association was observed with estrogen receptor expression.
Innate immune response reflects disease activity in eosinophilic granulomatosis with polyangiitis

Eosinophilic granulomatosis with polyangiitis (EGPA) is a disease characterized by allergic granulomatosis, necrotizing vasculitis, and peripheral blood eosinophilia. Interleukin (IL)‐33, thymic stromal lymphopoietin (TSLP), and type 2 innate lymphoid cells (ILC2) are involved in the innate and type 2 immune responses in EGPA. However, the relationships among these molecules and the mechanisms underlying the development of EGPA remain unknown.
Continuous Learning from Human Post-Edits for Neural Machine Translation

Abstract Improving machine translation (MT) by learning from human post-edits is a powerful solution that is still unexplored in the neural machine translation (NMT) framework. Also in this scenario, effective techniques for the continuous tuning of an existing model to a stream of manual corrections would have several advantages over current batch methods. First, they would make it possible to adapt systems at run time to new users/domains; second, this would happen at a lower computational cost compared to NMT retraining from scratch or in batch mode. To attack the problem, we explore several online learning strategies to stepwise fine-tune an existing model to the incoming post-edits. Our evaluation on data from two language pairs and different target domains shows significant improvements over the use of static models.
A Randomized, Double-Blind, Placebo-Controlled Study of the Analgesic Efficacy of Intravenous Acetaminophen in Ambulatory Surgery

Purpose: We investigated whether intraoperative intravenous acetaminophen has the potential to reduce pain after ambulatory surgery and reduce time to discharge from the post anaesthesia care unit and hospital. Methods: We tested this hypothesis by conducting a prospective randomized, double-blind clinical trial in patients undergoing ambulatory surgery. A total of 145 patients were randomized to pre and postoperative placebo (50), intravenous (IV) operative and postoperative oral acetaminophen (49), and pre and postoperative oral acetaminophen (48). Results: The primary end point; visual analogue scale mean pain intensity over 24 hours after completion of surgery, was not significantly different between the 3 groups, control group 2.0 (1.6), mean (SD), (IV) acetaminophen group 2.1 (1.9) and oral acetaminophen group 2.1 (1.6); (p=0.93). Time to fitness for discharge from the postoperative care unit (p=0.77) and time to fitness for discharge from hospital (p=0.27) also did not vary significantly between the three groups. Conclusion: The addition of intraoperative IV acetaminophen to a standard analgesia regimen in patients undergoing ambulatory surgery did not significantly improve pain control or discharge times after surgery compared with pre and postoperative oral acetaminophen or placebo.
Seasonal Metabolic Variation in Birds : Functional and Mechanistic Correlates

The influence of seasonal changes in temperature and climate on metabolic rates in birds has been a topic of interest to ornithologists and ecophysiologists for decades (e.g., Hart 1962; Dawson 1958; Miller 1939). Because metabolic rates increase linearly with temperature in endotherms outside the thermal neutral zone, comparisons of metabolic rates among seasons or species require standardized measurements of metabolic rates. The most common of these standardized metabolic rates used for comparisons of energetics among seasons or species is basal, or resting, metabolic rate. It often serves as a baseline for comparisons of metabolic costs of activities within species, and for comparisons of the “rate of living” among species or species groups (e.g., Wiersma et al. 2007a; White et al. 2007; McKechnie et al. 2006; McKechnie and Wolf 2004; Trevelyan et al. 1990; McNab 1988; Bennett and Harvey 1987; Kersten and Piersma 1987). Theoretically, basal metabolic rate (BMR) is the minimum metabolic rate required for maintenance in endotherms. BMR is measured within the thermal neutral zone under postabsorptive digestive conditions during the resting phase of the daily cycle on resting, nongrowing, nonreproductive animals (McNab 1997). It is doubtful whether truly BMRs can ever be achieved in the laboratory, so the term resting metabolic rate (RMR) is often used to refer to such measurements, even when the standard conditions for BMR have been met. Here, I will revert to the standard terminology and consider BMR as the metabolic rate measured under the standard conditions listed above, recognizing that this may not, in fact, represent truly basal rates (Table 3.1).
High Resolution Radar Quantitative Precipitation Estimation in the San Francisco Bay Area: Rainfall Monitoring for the Urban Environment

An X-band radar system was deployed in Santa Clara, CA from February through May 2016 to support the National Weather Service in the event of potential flooding during one of the largest El Niños on record and to provide a better understanding of rainfall processes occurring in the Bay Area. The system was also used to provide high-quality precipitation estimation (quantitative precipitation estimation—QPE) for Santa Clara’s urban hydrologic modeling system. Although the Bay Area has coverage from the Next-Generation Weather Radar (NEXRAD) operational radar network, the combination of topographic influences and proximity to a maritime environment provide unique QPE challenges in this urban region. The X-band radar provided high-quality rainfall estimates that performed better than NEXRAD, demonstrating the added value of the X-band system. High-resolution rainfall monitoring systems in urban regions also provide a host of benefits across different sectors of the economy, including flood damage mitigation, water quality, water supply, and transportation.
Hematology and Blood Chemistry Reference Intervals for Yellow Perch (Perca flavescens) Raised in Recirculation Systems

Determination of hematology and blood plasma biochemistry values is routinely used to assess the health of wild and domestic animals. Yellow perch (Perca flavescens) culture is a growing segment of the U.S. aquaculture industry and tools are needed to monitor the health status of these fish. This paper reports reference values for complete hematological and biochemistry profiles of normal, healthy yellow perch raised in recirculation culture conditions. The following hematologic values were determined: packed cell volume, plasma protein, erythrocyte, leukocyte, lymphocyte, neutrophil, monocyte, and thrombocyte numbers. A description of leukocyte morphology is presented. Additionally, the following plasma biochemical values were determined: total protein, albumin, globulin, creatinine, total bilirubin, alkaline phosphatase, aspartate aminotransferase, sodium, potassium, chloride, calcium, phosphorus, magnesium, glucose, and cholesterol. Reference values for a specific population of fish need to be determined prior to utilizing diagnostic blood samples from individuals. Developing diagnostic hematology for fishes can enhance yellow perch culture by providing a means for the early detection and identification of infectious disease and of sub-lethal conditions that may affect production performance.
ANALYSIS OF EVACUATION PERFORMANCE OF MERGIING POINTS IN STADIUMS BASED ON CROWD SIMULATION

Holding huge amount of spectators simultaneously during sports and recreational events, the problem of outdoor stadiums is increasingly focusing on how to improve evacuation performance. At first, the prescriptive codes related to stadium evacuation were compared, and the characteristics and movements of stadium crowd were studied to build more reliable evacuation simulation scenarios. Next, the design variations of most congested merging points in outdoor stadiums, which involve gangway intersections, vomitory access and stairway access underneath the stands were investigated. Finally, we used a CA model to simulate the evacuation processes in different cases. By analyzing the output value of egress time, waiting time and total cost through the journey, evacuation performances of different design strategies were compared and discussed.
Exploring the roles of substrate‐binding surface of the chaperone site in the chaperone activity of trigger factor

Trigger factor (TF) is a key component of the prokaryotic chaperone network, which is involved in many basic cellular processes, such as protein folding, protein trafficking, and ribosome assembly. The major chaperone site of TF has a cradle‐like structure in which protein substrate may fold without interference from other proteins. Here, we investigated in vivo and in vitro the roles of hydrophobic and charged patches on the edge and interior of cradle during TF‐assisted protein folding. Our results showed that most of the surface of the cradle was involved in TF‐assisted protein folding, which was larger than found in early studies. Although the inner surface of cradle was mostly hydrophobic, both hydrophobic and electrostatic patches were indispensable for TF to facilitate correct protein folding. However, hydrophobic patches were more important for the antiaggregation activity of TF. Furthermore, it was found that the patches on the surface of cradle were involved in TF‐assisted protein folding in a spatial and temporal order. These results suggest that the folding‐favorable interface between the cradle and substrate was dynamic during TF‐assisted protein folding, which enabled TF to be involved in the folding of substrate in an aggressive manner rather than acting as a classic holdase. —Fan, D. , Cao, S. , Zhou, Q. , Zhang, Y. , Yue, L. , Han, C. , Yang, B. , Wang, Y. , Ma, Z. , Zhu, L. , Liu, C. Exploring the roles of substrate‐binding surface of the chaperone site in the chaperone activity of trigger factor. FASEB J. 32, 6655–6665 (2018). www.fasebj. org
Traumatic Injury of the Inferior Alveolar Nerve after Dental Implant Surgery; a Literature Review

Osseointegration was the hallmark of success in implant dentistry in the 1980s. However, implant success in the 21st century involves other factors including: stability of the implant, adequate radiographic bone levels, lack of symptoms or evidence of infection, minimal probing depths around the implant, and the ability of the patient to keep the area clean. Although implant dentistry is a very dynamic and exciting area of oral treatment, it does not guarantee results, nor is it without temporary and/or permanent post-operative complications (e
Comparison of Airtraq and Trueview EVO2 with Macintosh Laryngoscope for Endotracheal Intubation by Experienced Anaesthesiologists: A Controlled Clinical Trial

Background: The purpose of the study was to evaluate the efficacy of two new laryngoscopes by experienced anaesthesiologists. Airtraq and Truview EVO2 were compared with gold standard Macintosh laryngoscope for endotracheal intubation of elective surgical patients with normal airway distribution. Methods: In prospective, randomised and controlled manner 150 patients of either sex above 18 yrs, presenting for elective surgery were randomly allocated in three equal groups. Endotracheal intubation was done using either Macintosh (group ML), Airtraq (group AQ) or Trueview (groupTL) laryngoscope. Laryngoscopic view of glottis (Cormac and Lehane grade), time taken for intubation , subjective assessment for ease of intubation, intubation difficulty scale (IDS) score as well as attempts for successful intubation, success rate and soft tissue injury during laryngoscopy and intubation were compared. Results: All the patients intubated with Airtraq and Trueview had Cormack and Lehane grade I or II and none had grade III in comparison with 42 (84%) having grade I or II and 8(16%) having grade III (p<0.05). Mean time taken for intubation was significantly longer with Truview (35.3±11.5sec) and comparable between Airtraq (19.2±4.7 sec) and Macintosh (24.4±13.8 sec) (p<0.05). On subjective assessment Truview was rated as most difficult device to use for intubation amongst three laryngoscopes. Truview and Airtraq had mean IDS scores of <1 (0.75± 0.4 and 0.56± 0.5 respectively) while a higher score (1.76±2) was found with Macintosh (p<0.05). No significant difference was noted in terms of attempts at intubation, success rate and soft tissue injury. Conclusion: We concluded that Airtraq was a promising and reliable alternative to Macintosh for endotracheal intubation of patients with normal airway characteristics in experienced hands. Although Trueview provided better intubating conditions than Macintosh, it took longer time for intubation and on subjective assessment, it was graded as difficult to use.
Evaluation of antidepressant-like activity of glycyrrhizin in mice

OBJECTIVE: To investigate the antidepressant-like effect of glycyrrhizin (glycyrrhizic acid ammonium) in mice. MATERIALS AND METHODS: Glycyrrhizin (1.5, 3.0 and 6.0 mg/kg, i.p.) was administered once daily for seven successive days to separate groups of young male Swiss albino mice. The immobility periods of control and treated mice were recorded in forced swim test (FST) and tail suspension test (TST). Effect of sulpiride (50 mg/kg, i.p.; a selective D2 receptor antagonist), prazosin (62.5 µg/kg, i.p.; an a1-adrenoceptor antagonist) and p-chlorophenylalanine (100 mg/kg, i.p.; an inhibitor of serotonin synthesis) on antidepressant-like effect of glycyrrhizin in TST was also studied. The antidepressant-like effect of glycyrrhizin was compared to that of imipramine (15 mg/kg, i.p.) and fluoxetine (20 mg/kg, i.p.) administered for seven successive days. RESULTS: Glycyrrhizin produced significant antidepressant-like effect at a dose of 3.0 mg/kg administered for seven successive days, as indicated by reduction in the immobility times of mice in both FST and TST. Glycyrrhizin did not show significant effect on locomotor activity of mice. The efficacy of glycyrrhizin was found to be comparable to that of imipramine and fluoxetine. Sulpiride and prazosin significantly attenuated the glycyrrhizin-induced antidepressant-like effect in TST. On the other hand, p-chlorophenylalanine did not reverse antidepressant-like effect of glycyrrhizin. This suggests that the antidepressant-like effect of glycyrrhizin seems to be mediated by an increase in brain norepinephrine and dopamine, but not by an increase in serotonin. CONCLUSION: The results of the present study indicate the involvement of adrenergic and dopaminergic systems in the antidepressant-like effect of glycyrrhizin.
Effects of straw incorporation on the yield, nitrogen fertilizer and insecticide requirements of sugarbeet (Beta vulgaris)

SUMMARY Incorporation of large amounts of straw (8–15 t/ha dry matter) into the soil had no effect on the incidence of soil pests and diseases or sugarbeet seedling population densities in experiments performed over three seasons (1984/85 to 1986/87) in Suffolk. Straw incorporation had no effect on sugar yield at the recommended rate of nitrogen fertilizer application, but the sugar yield and nitrogen uptake were reduced in one year by the incorporation of straw when the rate of applied nitrogen was low. It is probable that incorporating straw reduced the amount of nitrogen leached over the winter; however, the longer-term implications of straw incorporation remain to be assessed.
Lean Mass and Disease Activity are the Best Predictors of Bone Mineral Loss in the Premenopausal Women with Rheumatoid Arthritis

Background and Objectives: Factors determining bone mineral (BM) loss in rheumatoid arthritis (RA) are not well known. This study aimed to determine the occurrence and predictors of BM loss in the young premenopausal women with RA. Methods: Ninety-six females with RA and 90 matched controls underwent clinical, biochemical, BM density (BMD), and body composition assessments. RA disease activity was assessed using disease activity score-28 (DAS-28) and hand X-ray. Results: In the young premenopausal females with RA having median symptom and treatment duration of 30 (18–60) and 4 (2–12) months, respectively, with moderate disease activity (DAS-28, 4.88 ± 1.17), occurrence of osteoporosis and osteopenia was 7.29% and 25% at spine, 6.25% and 32.29% at hip, and 17.7% and 56.25% at wrist, respectively (significantly higher than controls). RA patients had lower BMD at total femur, lumbar spine (LS), radius total, and radius ultra-distal. Total lean mass (LM) and BM content were significantly lower in RA (P = 0.022 and <0.001, respectively). In RA, BMD at majority of sites (LS, neck of femur, greater trochanter, radius total, and radius 33%) had the strongest positive correlation with LM followed by body fat percent. RA patients with most severe disease had lowest BMD at different sites and lowest LM. Stepwise linear regression revealed LM followed by DAS-28 to be best predictors of BMD. RA patients receiving glucocorticoids did not have significantly different BMDs from patients not taking glucocorticoids. Interpretation and Conclusion: BM loss is a significant problem in the young premenopausal women with recent-onset RA. LM and disease severity were the best predictors of BMD.
Why should we use 3D Collaborative Virtual Environments for Cyber Security?

Cyber Security data analysis is an important growing domain: more and more data visualization systems are offered to operators in order to improve their threat detection performances or facilitate suspect behaviors characterization. As today Cyber Security trend is to regroup employees in structures such as Security Operations Center (SOC) or Computer Emergency Response Team (CERT), collaborative approach seems to be relevant in this context. We think that 3D Collaborative Virtual Environments (3DCVE) can be used in order to improve users Cyber Situational Awareness, as they can allow them to have a better understanding of a cyber situation by mediating interactions towards them and also by providing different points of view of the same data, on different scales.
Paleoclimatic Reconstruction Using the Correlation in δ18O of Hackberry Carbonate and Environmental Water, North America

Abstract Celtis sp. (commonly known as “hackberry”) fruits were collected from 101 North American sites located in 13 states and one Canadian province between the years of 1979–1994. The biomineralized carbonate endocarp of the hackberry, which is a common botanical fossil found throughout the Quaternary sediments of the Great Plains, was analyzed for its δ18O value and plotted against the δ18O value of site environmental water to demonstrate the potential of the hackberry as a paleoclimate indicator. This correlation was reinforced by intensive studies on extracted tissue-water δ18O value and hackberry endocarp carbonate δ18O value from three trees in Sterling, Colorado. The observed correlation in the large data set between hackberry endocarp carbonate δ18O value and environmental water is [endocarp δ18O=38.56+0.69×environmental water δ18O] (R=0.88; R 2=0.78; p value<0.0001). The relation of the hackberry carbonate to temperature in the Great Plains was the following: (average daily-maximum growing season temperature [°C])=6.33+0.67 (δ18O of endocarp carbonate) (R=0.73; R 2=0.54; p value=0.0133). The δ18O value of early Holocene fossil hackberry carbonate in the Pintwater Cave, southern Nevada, suggested precipitation δ18O values more positive than today (∼−4‰ early Holocene vs ∼−9 to −10‰ today). This shift, combined with paleobotanical data, suggests an influx of summer monsoonal moisture to this region in the early Holocene. Alternatively, the more positive δ18O values could be viewed as suggestive of warmer temperatures, although the direct use of Great Plains hackberry/temperature relationships to the Great Basin is of debatable value.
A fast analytical algorithm for generating CGH of 3D scene

We present a set of analytical formula on describing the diffraction field of the three dimensional (3D) triangular-meshbased model. The advantage of the proposed method is that it can avoid using the numerical algorithm -- Fast Fourier Transform, which leads to a depth-of-field limitation by the Whittaker-Shannon sampling theorem. We employ the proposed method to generate the hologram of 3D texture model derived from the real scene or 3D design software. In order to further increase the computation speed, we have rendered a real scene by employing the GPU platform. Our homemade GPU algorithm performs hundreds of times faster than those of CPU. As we developed a general phase adjustment technique for polygon-based algorithm, the holographic reconstructed scenes possess high performance.