Miracle-dz/UniFAR-FTUs huggingface dataset:
Rivaroxaban in patients with atrial fibrillation: from ROCKET AF to everyday practice

ABSTRACT Introduction: Registries and non-interventional studies offer relevant and complementary information to clinical trials, since they have a high external validity. Areas covered: The information regarding the efficacy and safety of rivaroxaban compared with warfarin, or rivaroxaban alone in clinical practice was reviewed in this manuscript. For this purpose, a search on MEDLINE and EMBASE databases was performed. The MEDLINE and EMBASE search included both medical subject headings (MeSH) and keywords including: atrial fibrillation (AF) OR warfarin OR clinical practice OR ROCKET AF AND rivaroxaban. Case reports were not considered. Expert commentary: In ROCKET AF, rivaroxaban was at least as effective as warfarin for the prevention of stroke in patients with nonvalvular AF at high risk of stroke, but, importantly, with a lesser risk of intracranial, critical and fatal bleedings. A number of observational comparative and non-comparative studies, with more than 60,000 patients included treated with rivaroxaban, have analyzed the efficacy and safety of rivaroxaban in real-life patients with AF in different clinical settings. These studies have shown that in clinical practice, rates of stroke and major bleeding were consistently lower than those reported in ROCKET AF, likely due to the lower thromboembolic and bleeding risk observed in these patients.
Customer involvement, fashion consciousness, and loyalty for fast-fashion retailers

The purpose of this paper is to investigate how customer involvement in product development creates an emotional connection, satisfaction, and subsequent loyalty toward fast-fashion retailers across high vs low fashion-conscious consumers. ,Both qualitative and quantitative methods were used to gain understandings of the impacts of customer involvement. To explore customers’ general perceptions of fast-fashion retailers, a focus group interview with 11 US students was conducted. Data for a hypothesis test were obtained from 306 US female consumers and analyzed through structural equational modeling. ,The findings underscored the relational benefits of involving customers in product development and the substantial moderating impact of female customers’ fashion consciousness. ,The study’s findings support that the customer-brand relationship can be solidified by proactively involving customers in product development. This is beyond benefits derived from leveraging customers’ operant resources in product innovation. Thus, apparel retailers should take such interactive opportunities to build relationships with customers. Also, involving customers in product development can be a critical way for fast-fashion retailers to establish an emotional bond with and loyalty from consumers with a low level of fashion consciousness. Thus, any digital opinion platform designed to foster customer involvement should be managed with the customer-brand relationship in mind. ,This study contributes to the emerging body of literature on customer involvement in product development in fast-paced retailing by elucidating the psychological process through which their participation strengthens the customer-brand relationship manifested in emotional, evaluative, and behavioral responses to the brand, and by identifying a consumer attribute that fortifies this process.
DISCOVERY OF A WIDE PLANETARY-MASS COMPANION TO THE YOUNG M3 STAR GU PSC

We present the discovery of a comoving planetary-mass companion ∼42″ (∼2000 AU) from a young M3 star, GU Psc, a likely member of the young AB Doradus Moving Group (ABDMG). The companion was first identified via its distinctively red i − z color (>3.5) through a survey made with Gemini-S/GMOS. Follow-up Canada–France–Hawaii Telescope/WIRCam near-infrared (NIR) imaging, Gemini-N/GNIRS NIR spectroscopy and Wide-field Infrared Survey Explorer photometry indicate a spectral type of T3.5 ± 1 and reveal signs of low gravity which we attribute to youth. Keck/Adaptive Optics NIR observations did not resolve the companion as a binary. A comparison with atmosphere models indicates Teff = 1000–1100 K and log g = 4.5–5.0. Based on evolution models, this temperature corresponds to a mass of 9–13 MJup for the age of ABDMG (70–130 Myr). The relatively well-constrained age of this companion and its very large angular separation to its host star will allow its thorough characterization and will make it a valuable comparison for planetary-mass companions that will be uncovered by forthcoming planet-finder instruments such as Gemini Planet Imager and SPHERE.
Strategi Pemasaran Sekolah Dalam Peningkatan Minat Peserta Didik Berdasarkan Delta Model

The purpose of this study is to develop a school marketing strategy in increasing customer interest. This research is limited to the stage of product manufacturing. Data were collected using documentation study, observation, and in-depth interviews. Data is validated by source and techniques triangulation. Data analysis techniques using Miles and Huberman Model (interactive model): data reduction, presentation data, and conclusion/verification. The result of this research: 1) the implemented strategy is to use a promotional strategy by spreading brochures and/or presentations to predetermined schools and churches, word of mouth organizing month language events every year, and activities/program held/followed by school, 2) obstacles and lack of marketing strategy implemented by this school in increasing the interest of learners that time management is not right, committee less active, foundation not yet involved, dissemination of brochure less effective, marketing is less extensive, does not yet have a document of school marketing strategy, and has not been able to ensure and communicate that the services offered are relevant to the needs of the community, and 3) The resulting product is a school marketing strategy based on the Delta Model in the interest of learners: a) Best Product Strategy: conducting holistic education through various school activities/programs that are unique and relevant to customer needs, and apply multi payment system to simplify customer conduct financial transactions; b) Total Customer Solutions Strategy: maximize resources owned by the company and facilitate the human resources who participate in the competitions/activities to meet their needs, and give appreciation of the effort/achievement of human resources; and c) System Lock-In Strategy: enforcing contract system with certain experts/clients within a certain period of time to lock customer, implement career path system for teachers and school staff, and have special cooperation and instructions which applies to alumni, high school favorites, certain universities, and other educational institutions.
First‐time primary caregivers' experience accessing first‐episode psychosis services

Aim: Easy access to first‐episode psychosis (FEP) services is critical in reducing the duration of untreated illness. However, primary caregivers can encounter difficulties accessing services on behalf of young people with FEP. This qualitative study describes the lived experience of first‐time primary caregivers of young adults with FEP, with a focus on examining how they access specialist FEP services.
Bayes's theorem and weighing evidence by juries

At first sight, there may appear to be little connection between Statistics and Law. On closer inspection it can be seen that the problems they tackle are in many ways identical — although they go about them in very different ways. In a broad sense, each subject can be regarded as concerned with the Interpretation of Evidence. I owe my own introduction to the common ground between the two activities to my colleague William Twining, Professor of Jurisprudence at University College London, who has long been interested in probability in the law. In our discussions we quickly came to realise that, for both of us, the principal objective in teaching our students was the same: to train them to be able to interpret a mixed mass of evidence. That contact led to my contributing some lectures on uses and abuses of probability and statistics in the law to the University of London Intercollegiate LlM course on Evidence and Proof (and an Appendix on “Probability and Proof” to Anderson and Twining (1991)), as well as drawing me into related research (Dawid 1987; Dawid 1994; Dawid and Mortera 1996; Dawid and Mortera 1998). To my initial surprise, I found here a rich and stimulating source of problems, simultaneously practical and philosophical, to challenge my logical and analytical problem-solving skills. For general background on some of the issues involved, see Eggleston (1983); Robertson and Vignaux (1995); Aitken (1995); Evett and Weir (1998); Gastwirth (2000). The current state of legal analysis of evidence seems to me similar to that of science before Galileo, in thrall to the authority of Aristotle and loth to concede the need to break away from old habits of thought. Galileo had the revolutionary idea that scientists should actually look at how the world behaves. It may be equally revolutionary to suggest that lawyers might look at how others have approached the problem of interpretation of evidence, and that they might even have something to learn from them. It is my strong belief (though I do not
Strengths Gym: The impact of a character strengths-based intervention on the life satisfaction and well-being of adolescents

This preliminary research study examined the impact of Strengths Gym, a character strengths-based positive psychological intervention program, on adolescent life satisfaction. Using a quasi-experimental treatment-control condition design, the study compared student outcomes for life satisfaction, positive and negative affect, and self-esteem for 319 adolescent students aged 12–14 (M = 12.98): 218 adolescent students who participated in character strengths-based exercises in the school curriculum, and 101 adolescent students who did not participate in character strengths-based exercises in the school curriculum. Results revealed that adolescents who participated in character strengths-based exercises experienced significantly increased life satisfaction compared to adolescents who did not participate in character strengths-based exercises. Overall, results provide encouraging preliminary support for the application of character strengths-based exercises in the school curriculum as a means of increasing life satisfaction and well-being among youths.
The general fertility rate in women with psychotic disorders.

OBJECTIVE This study determined the general fertility rate and age-specific fertility rates for women with psychotic disorders. METHOD This historical matched-cohort study of patient records from a primary care database (the General Practice Research Database) was carried out for women of childbearing age (15-44 years) with psychotic disorders. RESULTS The women with psychotic disorders (N=7,936) had a lower overall general fertility rate than the normal comparison subjects (N=23,023), although fertility was only significantly lower in the women aged 25 and above. This lower fertility rate was less marked in women with affective psychoses. There was no evidence that treatment with neuroleptics influenced the fertility rate in women with non-affective psychoses. CONCLUSIONS This study found markedly lower fertility rates in women with psychotic disorders than in matched normal comparison subjects, particularly in women with non-affective disorders. Knowledge of fertility rates in women with psychotic disorders is fundamental for clinicians and researchers, since it has implications for family planning services, prevention of obstetric complications, child-care support, and hypotheses about the etiology of these disorders.
Modélisation des interactions rotor-stator par une méthode d'équilibrage harmonique

Malgre les progres faits dans les dernieres decennies en CFD, les techniques RANS instationnaires pour les turbomachines multi-etages sont toujours tres couteuses en temps de calcul, reduisant leur interet en conception industrielle. Grâce a une analyse de Fourier, les equations instationnaires de Navier-Stokes peuvent etre considerees comme 2N+1 equations stationnaires couplees par un terme source. Cette approche calcule efficacement les ecoulements instationnaires periodiques et montre de forts gains en terme de temps de calcul. Cependant, l’expression du terme source est algebrique, ce qui provoque des difficultes dans le calcul de l’inverse de la transformee de Fourier directe. Afin d’ameliorer la robustesse et la precision de la methode, une approche basee sur un echantillonnage temporel non-uniforme est adoptee. Pour reduire le domaine de calcul a un unique passage inter-aube des conditions aux limites de chrochronicite sont developpees. Dans un premier temps, un rotor et un stator sont simules avec en une entree du domaine de calcul une injection qui modelise le sillage de la roue directrice d’entree. Ainsi, deux frequences fondamentales sont vues par le rotor. L’influence du contenu frequentiel dans le rotor (i.e. le nombre d’harmoniques de la frequence de passage des roues et leurs combinaisons) est analysee. Les resultats sont valides contre ceux obtenus avec des simulations instationnaires classiques. Ensuite, la methode est appliquee a deux compresseurs industriels, le compresseur transsonique ECL4 et le compresseur d’etude CREATE.
Does Organic Food Consumption Signal Prosociality?: An Application of Schwartz’s Value Theory

ABSTRACT Current research suggests that sustainable consumption choices (including favoring organic foods) can act as signals of prosociality. However, who actually perceives such acts as indicators of prosocial, altruistic tendencies is still unclear. Through an online survey (n = 168) and by using personal value priorities (Schwartz’s theory of values) as IVs, the present study sheds light on this issue. First, the results suggest that organic food consumption can confer the valuable signal of prosociality – and some other socially valued traits were also associated with this everyday behavior strategy. Then, the study shows that the interpretation of the signal is dependent on respondents’ positioning in Schwartz’s value circumplex. Intriguingly, in addition to those people who endorse self-transcendence values, people with conservative value priorities also view the presumed organic consumer as prosocial. These impressions are further mediated by more specific organic food attitudes, thereby forming a value–attitude–impression relationship. The implications are outlined.
The treatment of pleomorphic adenomas by formal parotidectomy

We reviewed 100 patients who underwent formal parotidectomy. Seventy‐two were new patients in whom a parotid lump proved to be a pleomorphic adenoma. Twenty‐eight were patients in whom a tumour had recurred after treatment for pleomorphic adenoma by local excision (with or without irradiation) elsewhere. After a follow‐up of 1–15 years (median 4 years), there were no recurrences in the primary group but 5 recurrences among the secondary cases. Permanent facial nerve damage was not seen in the primary group, but 11 patients undergoing secondary parotidectomy were left with some permanent facial weakness. Malignant change occurred in 4 patients in the secondary group.
Azithromycin susceptibility among clinical isolates of Salmonella: Interfacing guidelines with routine practices

including its ability to reach very high levels at intracellular spaces where Salmonella commonly resides despite its low serum levels and high MIC values have contributed to the good clinical response. However, an important concern is its prolonged sub-inhibitory concentrations at tissue might favour emergence of bacterial resistance highlighting the need to monitor MIC of Salmonellae against azithromycin. [1] Our results differ from other Indian reports of slightly higher azithromycin MICs while it is agreeable with data from other developing nations. [3,4] In our study, S. Paratyphi-A seems to be relatively more resistant compared to S. Typhi, a fact that is supported by earlier report from Nepal that state the MICs of several antimicrobial agents were higher among isolates of S. Paratyphi-A. [5] Recently, increase in the occurrence of S. Paratyphi-A infections and non-availability of vaccine raises public health concern over this pathogen. Higher MICs Dear Editor,
Cyanoacrylate closure of incompetent great, small and accessory saphenous veins without the use of post-procedure compression: Initial outcomes of a post-market evaluation of the VenaSeal System (the WAVES Study)

Purpose Cyanoacrylate closure of the great saphenous vein with the VenaSeal™ Closure System is a relatively new modality. Studies have been limited to moderate-sized great saphenous veins and some have mandated postoperative compression stockings. We report the results of a prospective study of cyanoacrylate closure for the treatment of great saphenous vein, small saphenous veins, and/or accessory saphenous veins up to 20 mm in diameter. Methods Fifty subjects with symptomatic great saphenous vein, small saphenous veins, and/or accessory saphenous veins incompetence were each treated at a single session. Compression stockings were not used post-procedure. Subjects returned to clinic at week 1 and again at one month. Post-procedure evaluations were performed at seven days and one month and included numerical pain rating score, revised venous clinical severity score, the Aberdeen Varicose Vein Questionnaire score, and time to return to work and normal activities. Duplex ultrasound was performed at each visit. Findings Procedural pain was mild (numerical pain rating scale 2.2 ± 1.8). All treated veins (48 great saphenous vein, 14 accessory saphenous veins, and 8 small saphenous veins) had complete closure by duplex ultrasound at seven days and one month. Mean time to return to work and normal activities was 0.2 ± 1.1 and 2.4 ± 4.1 days, respectively. The revised venous clinical severity score was improved to 1.8 ± 1.4 (p < .001) and Aberdeen Varicose Vein Questionnaire score to 8.9 ± 6.6 (p < .001) at one month. Phlebitis in the treatment area or side branches occurred in 10 subjects (20%) and completely resolved in all but one subject (2%) by one month; 98% of subjects were “completely” or “somewhat” satisfied, and 2% “unsatisfied” with the procedure at one month, despite the protocol disallowance of concomitant side branch treatment. Conclusions Cyanoacrylate closure is safe and effective for the treatment of one or more incompetent saphenous or accessory saphenous veins. Closure rates were high even in the absence of the use of compression stockings or side branch treatment. Time back to work or normal activities was short and improvements in venous severity scores and QOL were significant, comparing favorably with alternative treatment methods.
Structural insights into retinitis pigmentosa from unfolding simulations of rhodopsin mutants

Disease‐causing missense mutations in membrane proteins, such as rhodopsin mutations associated with the autosomal dominant form of retinitis pigmentosa (ADRP), are often linked to defects in folding and/or trafficking. The mechanical unfolding of wild‐type rhodopsin was compared with that of 20 selected ADRP‐linked mutants more or less defective in folding and retinal binding. Rhodopsin fold is characterized by networks of amino acids in the retinal and G‐protein binding sites likely to play a role in the stability and function of the protein. The distribution of highly connected nodes in the network reflects the existence of a diffuse intramolecular communication inside and between the 2 poles of the helix bundle, which makes pathogenic mutations share similar phenotypes irrespective of topological and physicochemical differences between them. Because of this communication, the ADRP‐linked rhodopsin mutations share a more or less marked ability to impair selected hubs in the protein structure network. The extent of this structural effect relates to the severity of the biochemical defect caused by mutation. The investigative strategy employed in this study is likely to apply to all structurally known membrane proteins particularly susceptible to misassembly‐causing mutations. —Fanelli, F. , Seeber, M. Structural insights into retinitis pigmentosa from unfolding simulations of rhodopsin mutants. FASEB J. 24, 3196–3209 (2010). www.fasebj. org
NEUVERKEHR - REALITAET ODER PHANTOM?

Infrastrukturbedingter Neuverkehr wird seit einigen Jahren in der Verkehrspolitik sehr kontrovers beurteilt und bewertet. Im Rahmen des Beitrages wird versucht, eine klare und scharfe Begrifflichkeit des Neuverkehrs einzufuehren, mit diesem Begriff ein klares theoretisches Konzept aufzubauen, das ingenieurwissenschaftliche und oekonomische Aspekte beruecksichtigen und interpretieren kann, und ein Fallbeispiel empirisch durchzuarbeiten. Das theoretische Konzept baut auf Einkommens-, Transportkosten- und Zeitelastizitaeten der Verkehrsnachfrage auf und zeigt Zusammenhaenge zwischen Nachfragefunktionen, Elastizitaeten und Kreuzelastizitaeten auf. Das "Gesetz vom konstanten Reisebudget" erweist sich dabei als ein (eher unwahrscheinlicher) Sonderfall von unendlich vielen denkbaren Nachfragefunktionen, in denen nur die Reisezeit als unabhaengige Variable aufscheint. Im gewaehlten Fallbeispiel werden zunaechst durch zeitliche Laengsschnittanalysen die Einfluesse von Einkommen und Transportkosten herausgefiltert, um den danach verbleibenden Verkehrsnachfrageueberschuss infolge einer singulaeren, gravierenden Angebotsattraktivitaet (Eroeffnung des Arlbergstrassentunnels am 1.12.1978) als infrastrukturbedingten Neuverkehr deuten zu koennen. Aus diesem wird dann versucht, eine Zeitelastizitaet zu rekonstruieren, um infrastrukturbedingten Neuverkehr mit Hilfe von Zeitelastizitaeten oekonomisch interpretieren zu koennen.
Phytochrome, Gibberellins, and Hypocotyl Growth (A Study Using the Cucumber (Cucumis sativus L.) long hypocotyl Mutant)

The possible involvement of gibberellins (GAs) in the regulation of hypocotyl elongation by phytochrome was examined. Under white light the tall long hypocotyl (lh) cucumber (Cucumis sativus L.) mutant, deficient in a type B-like phytochrome, shows an increased “responsiveness” (defined as response capability) to applied GA4 (the main endogenous active GA) compared to the wild type. Supplementing far-red irradiation results in a similar increase in responsiveness in the wild type. Experiments involving application of the precursor GA9 and of an inhibitor of GA4 inactivation suggest that both the GA4 activation and inactivation steps are phytochrome independent. Endogenous GA levels of whole seedlings were analyzed by combined gas chromatography-mass spectrometry using deuterated internal standards. The levels of GA4 (and those of GA34, the inactivated GA4) were lower in the lh mutant under low-irradiance fluorescent light compared with the wild type, similar to wild type under higher irradiance light during the initial hypocotyl extension phase, and higher during the phase of sustained growth, in which extension involved an increase in the number of cells in the upper region. In all cases, growth of the lh mutant was more rapid than that of the wild type. It is proposed that GA4 and phytochrome control cell elongation primarily through separate mechanisms that interact at a step close to the terminal response.