Miracle-dz/UniFAR-FTUs huggingface dataset:
Tinnitusrelief Device in Treatment of Bothersome Tinnitus: Preliminary Experience in Private Setting

Tinnitusrelief is a portable, noninvasive, handheld, rechargeable device which provides long term relief for tinnitus. Using the diagnose feature after identification of tinnitus frequency and intensity, Tinnitus Relief provides 22 customized sounds including narrow band and white band noises, in frequency range of 100 Hz 16KHz to cause habituation and neuromodulation providing relief in both recent onset and persistent bothersome tinnitus. The principle of the device design aligns with that of TRT (Tinnitus Retraining Therapy) and Neuromodulation.
SOROPREVALÊNCIA E FATORES DE RISCO PARA SÍFILIS EM POPULAÇÃO CARCERÁRIA DE GOIÁS

C o m o o b j e t i v o d e d i m e n s i o n a r a p r e v a l ê n c i a d a i n f e c ç ã o p e l o T r e p o n e m a p a l l i d u m e d e t e r m i n a r f a t o r e s d e r i s c o r e l a c i o n a d o s a s o r o p o s i t i v i d a d e f o r a m r a s t r e a d o s 2 9 9 p r e s i d i á r i o s n o C e n t r o P e n i t e n c i á r i o d e A t i v i d a d e s I n d u s t r i a i s d e G o i á s ( C E P A I G O ) , 20 K m d e G o i â n i a . O r a s t r e a m e n t o s o r o l ó g i c o f o i r e a l i z a d o u t i l i z a n d o s e c o m o c r i t é r i o d e p o s i t i v i d a d e , q u a l q u e r r e s u l t a d o s o r o r e a g e n t e a o V D R L i n d e p e n d e n t e m e n t e d o t í t u l o . A t r a v é s d e u m q u e s t i o n á r i o p a d r o n i z a d o f o r a m a v a l i a d o s o s s e g u i n t e s f a t o r e s d e r i s c o : t e m p o d e e n c a r c e r a m e n t o , s i n a i s e s i n t o m a s r e l a t i v o s à s p r i n c i p a i s d o e n ç a s s e x u a l m e n t e t r a n s m i s s í v e i s ( D S T ) , h i s t ó r i a d e s í f i l i s o u o u t r a s D S T e p r á t i c a s s e x u a i s ( h o m o / b i s s e x u a l i s m o e n ú m e r o d e p a r c e i r o s ) . F o r a m c a l c u l a d o s o v a l o r p r e d i t i v o p o s i t i v o ( V P P ) e n e g a t i v o ( V P N ) d a h i s t ó r i a p r e g r e s s a d e s í f i l i s o b t i d a n a a n a m n e s e . U m a s o r o p r e v a l ê n c i a g l o b a l d e 1 8 , 4 % f o i o b t i d a , n ã o h a v e n d o d i f e r e n ç a e n t r e a s f a i x a s e t á r i a s . O V P P d o a n t e c e d e n t e d e s í f i l i s f o i d e 2 6 % s i g n i f i c a n d o q u e 7 4 % d o s i n d i v í d u o s q u e r e f e r i r a m s í f i l i s n o p a s s a d o n ã o t i v e r a m c o n f i r m a ç ã o p e l o V D R L . E n t r e o s f a t o r e s d e r i s c o t e s t a d o s , a b i s s e x u a l i d a d e f o i o ú n i c o q u e a p r e s e n t o u a s s o c i a ç ã o e s t a t i s t i c a m e n t e s i g n i f i c a n t e c o m s o r o p o s i t i v i d a d e ( r i s c o r e l a t i v o 5,8 L C 9 5 % 1,2-16,0 p = 0 ,03 ) . F o r a m d i s c u t i d a s a s d i f i c u l d a d e s m é t o d o l ó g i c a s q u e p o d e r i a m t e r i n f l u e n c i a d o n o s r e s u l t a d o s .
Ribosome‐mediated translational pause and protein domain organization

Because regions on the messenger ribonucleic acid differ in the rate at which they are translated by the ribosome and because proteins can fold cotranslationally on the ribosome, a question arises as to whether the kinetics of translation influence the folding events in the growing nascent polypeptide chain. Translationally slow regions were identified on mRNAs for a set of 37 multidomain proteins from Escherichia coli with known three‐dimensional structures. The frequencies of individual codons in mRNAs of highly expressed genes from E. coli were taken as a measure of codon translation speed. Analysis of codon usage in slow regions showed a consistency with the experimentally determined translation rates of codons; abundant codons that are translated with faster speeds compared with their synonymous codons were found to be avoided; rare codons that are translated at an unexpectedly higher rate were also found to be avoided in slow regions. The statistical significance of the occurrence of such slow regions on mRNA spans corresponding to the oligopeptide domain termini and linking regions on the encoded proteins was assessed. The amino acid type and the solvent accessibility of the residues coded by such slow regions were also examined. The results indicated that protein domain boundaries that mark higher‐order structural organization are largely coded by translationally slow regions on the RNA and are composed of such amino acids that are stickier to the ribosome channel through which the synthesized polypeptide chain emerges into the cytoplasm. The translationally slow nucleotide regions on mRNA possess the potential to form hairpin secondary structures and such structures could further slow the movement of ribosome. The results point to an intriguing correlation between protein synthesis machinery and in vivo protein folding. Examination of available mutagenic data indicated that the effects of some of the reported mutations were consistent with our hypothesis.
All-Pay Auctions with Affiliated Values

This paper analyzes all-pay auctions where the bidders have affiliated values for the object for sale and where the signals take binary values. Since signals are correlated, high signals indicate a high degree of competition in the auction and since even losing bidders must pay their bid, non-monotonic equilibria arise. We show that the game has a unique symmetric equilibrium, and that whenever the equilibrium is non-monotonic the contestants earn no rents. All-pay auctions result in low expected rents to the bidders, but also induce inefficient allocations in models with affiliated private values. With two bidders, the effect on rent extraction dominates, and all-pay auction outperforms standard auctions in terms of expected revenue. With many bidders, this revenue ranking is reversed for some parameter values and the inefficient allocations persist even in large auctions.
Lack of any prognostic role of insulin-like growth factor-1 receptor in non-small cell lung cancer.

BACKGROUND The purpose of this study is to determine whether the IGF1R expression has a prognostic role in non-small cell lung cancer. MATERIALS AND METHODS Forty-seven patients histopathologically diagnosed with small cell lung cancer upon bronchoscopic biopsy or resection materials were included in the study. IGF1R expression was examined via immunohistochemical methods. In samples, >10% staining were assessed as positive and ≤10% as negative. Information about demographic datas and treatments was obtained by retrospective searches of patient files. RESULTS IGF1R expression was determined as positive in 38 (80.9%) and as negative in 9 (19.1%) patients. There was no significant relation between IGF1R expression and histological sub-type, local invasion, lymph node and metastasis status (p=0.842, p=0.437, 0.064, 0.447, respectively). There was also no correlation with IGF1R expression and survival (p=0.141). CONCLUSIONS There are conflicting results between IGF1R and its prognostic effects in the various studies. It has been claimed in some studies it is not related to prognosis as in our study, and in some studies it has been claimed that it is a good prognostic factor whereas in some studies it has been claimed as being a factor for worse prognosis. We think that IGF1R expression in non-small cell lung carcinoma patients deserves further analysis, because of its potential prognostic and predictive roles.
The induction of chromosome aberrations by nitrogen mustard and its dependence on DNA synthesis

The response of the chromosomes in root-tip cells of Vicia faba seedlings has been studied following the exposure of roots to 30 min combined treatments with [3H]thymidine and 10-6M nitrogen mustard (HN2). Autoradiographs were prepared from squash preparations of root-tips sampled up to 3 days after exposure and metaphase cells were scored for the presence of labelling and for chromosomal aberrations. Only chromatid-type aberrations were induced by HN2 treatment; chromosome-type aberrations characteristic of cells exposed to ionizing radiations whilst in the pre-DNA synthesis (G1) phase of interphase were not observed. At the first mitosis following treatment chromatid structural changes were observed in cells that were exposed to HN2 whilst in the G1 and DNA synthesis (S) phases of inter-phase, but no aberrations were found in cells exposed whilst in the post-DNA synthesis (G2) phase. In the second mitosis following treatment chromatid-type aberrations were observed in cells that were originally exposed to HN2 whilst in the G2 phase and were visibly undamaged at the first mitosis. The frequency of aberrations observed at the second mitosis in cells that were treated whilst in S or G2 was significantly higher than in S cells observed at the first mitosis. From these changes in response with cell phase and from the type of aberrations produced, it was concluded that although HN2 produces lesions in chromosomes independently of cell phase at the time of treatment, structural changes are only produced when the cells undergo DNA synthesis. The nature of the lesions is discussed and it is suggested that chromatid aberrations arise as a result of misreplication of DNA at the sites of alkylation, and that a proportion of the original lesions may be repaired. It is concluded that the high frequency of intrachange relative to interchange aberrations and the localization of aberrations to the heterochromatic regions of the chromosomes are consequences of the requirement for simultaneous replication in chromosome regions that are involved in aberration. The results are compared with those obtained in X-irradiated cells and the relative frequencies of intrachange types induced by HN2 are shown to be similar to the frequencies observed after X-irradiation of S cells but not of G2 cells. However, the intrachange frequencies do not conform with those predicted on Revell’s exchange hypothesis for aberration formation and it is suggested that this lack of agreement is due to the formation in S cells of some iso-chromatid aberrations through a process of misreplication at a single lesion.
An Experimental Study of Slot-Jet Impingement and Mist Cooling of Microprocessors

This paper describes an experimental study of air slot-impingement and mist cooling of microchannels fabricated on the back of a silicon chip. A rig was designed and fabricated for the experimental study. The test section consisted of a 21 mm times 21 mm square silicon die with 100 mum-wide microchannels etched on its back surface, which were covered with a glass plate to confine the flow through the microchannels. A slot was machined across the glass cover plate to admit air from an inlet manifold. The performance of an air-water mist spray cooling system was also studied experimentally. It was found that an air-water mist spray cooling system can give a higher cooling rate than air-only slot-impingement cooling of microchannels. For the same heat dissipation, it was found that the air-water mist spray cooling system required a much smaller flow rate of air. Comparing with data available in the literature, it was also found that mist cooling of microchannels was much more effective than on plane surfaces
Visual outcome of vitrectomy in seasonal hyperacute pan uveitis.

INTRODUCTION Seasonal Hyper Acute Panuveitis (SHAPU) is a sight threatening condition often affecting children. Its management as yet is a challenge in ophthalmic practice. Most of the eyes even after treatment end up in pthisis bulbi. MATERIALS AND METHODS A retrospective hospital based analysis of 18 patients with SHAPU managed with vitrectomy at Himalaya Eye Hospital (HEH) Pokhara over a period of two years was carried out. RESULTS Out of 18 patients 10 were males. Majority of them were below the age of 15 years. Best corrected visual acuity (BCVA) at presentation was less then 3/60 in 72% of them. BCVA was better then 6/60 in 7 (50%) out of 14 patients, who underwent vitrectomy. CONCLUSION Vitrectomy is a useful procedure in management of SHAPU.
Leveraging Information Technology Infrastructure to Facilitate a Firm's Customer Agility and Competitive Activity: An Empirical Investigation

This paper investigates how information technology (IT) facilitates a firm's customer agility and, in turn, competitive activity. Customer agility captures the extent to which a firm is able to sense and respond quickly to customer-based opportunities for innovation and competitive action. Drawing from the dynamic capability and IT business value research streams, we propose that IT plays an important role in facilitating a "knowledge creating" synergy derived from the interaction between a firm's Web-based customer infrastructure and its analytical ability. This will enhance the firm's ability to sense customer-based opportunities. IT also plays an important role in "process enhancing" synergy obtained from the interaction between a firm's coordination efforts and its level of information systems integration, which facilitates the firm's ability to respond to those opportunities. We also leverage the competitive dynamics and strategic alignment literature to propose that the alignment between customer-sensing capability and customer-responding capability will impact the firm's competitive activity. We test our model with a two-stage research design in which we survey marketing executives of high-tech firms. Our results show that a Web-based customer infrastructure facilitates a firm's customer-sensing capability; furthermore, analytical ability positively moderates this relationship. We also find that internal systems integration positively moderates the relationship between interfunctional coordination and a firm's customer-responding capability. Finally, our results show that agility alignment affects the efficacy of a firm's competitive actions. In particular, action efficacy is higher when sensing and responding capabilities are both high.
Seeing Double and Depth with Wheatstone's Stereograms

Charles Wheatstone, in his classic paper on the invention of the stereoscope, concluded “… objects whose pictures do not fall on corresponding points of the two retinæ may still appear single” (1838 Philosophical Transactions of the Royal Society of London 128 384). Soon after, Ernst Brücke, Alexandre Prévost, David Brewster, Joseph Towne, and Joseph LeConte all published disagreements with this conclusion. LeConte's objections were most frequent and most prolonged. To understand the basis of the disagreements, we conducted three experiments using Wheatstone's original stereograms and found that most stereograms produced depth perception with diplopia, which partially explains the consistency among his critics' conclusions. Most of the criticism at variance with Wheatstone's conclusion was based on research conducted outside Germany. We argue that LeConte's lack of knowledge of the German literature on vision research prevented him from considering investigating Wheatstone's experiment with a stereogram having a smaller disparity.
A comparison of two sphygmomanometers that may replace the traditional mercury column in the healthcare workplace

ObjectiveAlternatives to the traditional, but possibly toxic mercury sphygmomanometer are needed for accurate blood pressure measurements in the medical workplace. We compared the performance of two commercially available potential replacements for the mercury column; an anaeroid manometer (Baum & Co) and an automated oscillometric device (Omron HEM-907), using the mercury sphygmomanometer as a standard, in the same participants. MethodsTwo independent observers performed simultaneous triplicate blood pressure readings for 512 participants. The average difference and standard deviation of the difference comparing the mercury column vs. the anaeroid and automated devices were calculated for each of the three paired systolic and diastolic blood pressure readings. ResultsBoth devices met the Association for the Advancement of Medical Instrumentation criteria for sphygmomanometers (<5 mmHg average difference, <8 mmHg standard deviation of the difference) for all three readings. Compared with the mercury standard, there were no significant differences (by paired t-test) with the anaeroid device (−0.83/0.73 mmHg, P=0.25/0.09), but the automated device slightly overestimated systolic blood pressure (by 2.12 mmHg, P=0.002) and underestimated diastolic blood pressure (by 2.36 mmHg, P=0.0002). The first reading was significantly higher and had a larger standard deviation than the second or third readings across all manometers. ConclusionsThe automated device performed as well as an anaeroid manometer operated by well trained, experienced observers. The two alternative devices to the mercury sphygmomanometer examined in this study may be potential replacement devices for blood pressure measurement.
TROUBLE IN STORE: PROBES, PROTESTS AND STORE OPENINGS BY WAL-MART: 1998-2005 Forthcoming, American Journal of Sociology

Wal-Mart has increasingly become the target of protests over its scale, manifested as contention over specific expansions. Often, the protests are local and led by local organizations, and as a result, chains face uncertainty whether local activists will organize a protest. We suggest that chain stores respond to this uncertainty through a ‘test for protest’ approach. They use low-cost probes that take the form of proposals to open a store. They then withdraw if they face protests, especially when the contexts of those protests make them more costly, either in terms of legislative barriers, consumer demand, or encouragement of protests elsewhere. Wal-Mart is more likely to open stores that are particularly profitable, even if they are protested, and in such cases, they also make larger donations to community causes. We find broad support for our predictions. Our uncertainty-based account of protests as signals stands in sharp contrast to full-information models which predict that protests should be rare miscalculations.
Higher oesophageal temperature at rest and during exercise in humans with patent foramen ovale

Patent foramen ovale (PFO) is present in ∼35% of the general population. The respiratory system participates in thermoregulation via evaporative and convective heat loss so blood flow that bypasses the respiratory system, e.g. through a PFO, may not participate in respiratory system cooling. We found that subjects with a PFO (PFO+) had a ∼0.4°C higher oesophageal temperature (Toesoph) than subjects without a PFO (PFO−) during pre‐exercise and exercise. Toesoph in PFO+ subjects was associated with the estimated size of the PFO whereby subjects with a large PFO had a greater Toesoph than PFO− subjects and subjects with a small PFO. During high intensity exercise breathing cold and dry air, PFO+ subjects achieved a higher Toesoph than PFO– subjects. Absence of respiratory system cooling of shunted blood partially explains the differences in Toesoph between PFO+ and PFO– subjects; other differences in thermoregulatory responses that impact core temperature also likely exist.
The Impact of Consumer Product Package Quality on Consumption Satisfaction, Brand Perceptions, Consumer Investment and Behavior

Consumer product packaging can serve a critical role in the consumption experience, but marketing and packaging science researchers focus primarily on pre and post-consumption aspects of consumer product containers. Exhaustive research into packing ergonomics, logistics, safety, sustainability and promotional features are common across marketing and packaging disciplines, but research isolating the role of a packaging in consumption satisfaction and enduring consumer-brand relationships is rare. In addition to an undervalued role in product satisfaction, functional isolation between marketing and packaging scientists limits packaging’s overall impact on the bottom line. This research examines the role of bottle quality in bottled-water consumption satisfaction and its subsequent impact on brand attribute perceptions, consumer-brand relationship investment and behavioral intentions. We show that thicker water bottles are perceived to be of higher quality than thinner bottles, and that these perceptual differences impact how customers view a brand on aspects such as reliability and value offered by the brand’s products and ultimately intentions to re-purchase the brand’s products. We use qualitative, experimental and structural modeling analysis techniques to establish a fundamental role of packaging quality in consumer product satisfaction. We show that packaging characteristics are an indivisible component of the product and important to evaluation of the overall consumption experience. We finally conclude that packaging quality has a critical role to play in building profitable consumer-brand relationships, which should redefine the packaging cost-benefit equation to include the value of consumer loyalty as a balance to non-consumption packaging considerations.
Intravenous Amino Acid Therapy

ELMAN & WEINER (1939) were the first to administer amino acids intravenously to man in order to improve the nitrogen balance. Before solutions of crystalline L-amino acids were commercially available, protein hydrolysates were preferred for intravenous nutrition. Preparations of casein have been most extensively used. The hydrolysates have a good nutritive value but they also have some disadvantages. The amino acid composition depends upon the composition of the original protein. Furthermore, between 30 and 50 yo of the nitrogen is in form of peptides which are utilized less efficiently than free amino acids, especially in cases of posttraumatic catabolism (VINNARS et al. 1970). Hydrolysates also contain electrolytes. Based on the manufacturing principle established by BANS et al. (1964) several solutions made of crystalline L-amino acids are currently available. Clinical use of these solutions is showing an increasing trend.
Isolation and characterization of flagellar preparations from Pseudomonas species

Sodium dodecyl sulfate-polyacrylamide gel electrophoresis has been used previously to characterize the flagellin of Pseudomonas aeruginosa. flFlagella from several other clinically important species of pseudomonads have been characterized by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and their molecular weights have been found to vary among species as follows: P. maltophilia B69 Fla, 33,000; P. stutzeri HEW, 55,000; P. aeruginosa M-2, 53,000. The flagella of P. cepacia strains were divided into two groups based on molecular weight. Type I had a molecular weight of 31,000. The molecular weight of type II was in the range of 44,000 to 46,000. Serologically, type I is a homologous group, whereas type II is a heterologous group. The two flagellin types of P. cepacia appear to be analogous to the two major flagellin types of P. aeruginosa. Characterization of P. cepacia strains by flagellin types may serve as a molecular epidemiological tool.