Miracle-dz/UniFAR-FTUs huggingface dataset:
A two-stage therapeutic design in the spontaneous AKR lymphoma system.

For evaluation of the efficacy of chemotherapeutic agents in the remission-induction and remission-maintenance phases of leukemia, an experimental model was designed around the spontaneous AKR lymphoma. The system was based on palpating lymphoid tissue for the purpose of diagnosis of advanced spontaneous disease, treating with vincristine sulfate plus prednisone for remission induction, repalpating to determine the state of disease ( i.e. , remitters and nonremitters), and then placing groups of animals on various remission-maintenance regimens. The combination of vincristine sulfate plus prednisone induced remission in approximately 60% of animals, with the median survival time for animals in remission given placebo maintenance around 13 days from the day of remission. The maintenance agents were ranked according to their antitumor activity, and cytoxan was the most effective, increasing the median survival time 250% over the placebo-maintained groups. Analysis was also made of the total remission-induction plus remission-maintenance regimen, and results were compared to continuous single-drug therapy from Day 0. The regimens that included cytoxan maintenance were the most effective, but animals receiving the two-stage regimens did not live as long as animals given only cytoxan from the day of diagnosis. The murine chemotherapy model is presented as an experimental design useful for detailed studies analogous to clinical trials in leukemia and lymphoma.
Evaluation of CO(2) laser excision or vaporization for the treatment of vulvar intraepithelial neoplasia.

OBJECTIVE Our objective was to evaluate the results of laser surgery in patients with vulvar intraepithelial neoplasia (VIN). METHODS From January 1990 to December 1996, 52 patients with histologically proven VIN were treated with CO(2) laser vaporization or laser excision. The analysis included anamnestic characteristics, clinical aspects, types of treatment, correlation of the preoperative biopsy with the excised pathologic specimen, and follow-up results. RESULTS Fourteen women underwent laser vaporization, and 38, laser excision. Of the patients submitted to vaporization, 11 were cured in one session (75%), 1 required two procedures, and 2 other patients, who underwent more treatments, eventually developed invasive squamous cell cancer 5 and 7 years from the initial treatment. The cure rate for laser excision was better, as a single session of treatment was curative in 33 of 38 patients (87%). In 3 cases the pathology report on the excised specimen showed an unrecognized invasive lesion (12%) and the women underwent radical surgery. The 2 remaining patients, both affected by multifocal disease, experienced recurrences and were treated with laser excision 2 and 3 years after the primary treatment, respectively. Symptom relief was obtained in all patients studied with both laser vaporization and excision. CONCLUSIONS Excisional laser surgery is an effective treatment for patients with VIN. In addition, CO(2) laser excision allows evaluation of the operative specimen and detection of occult early invasion with good preservation of vulvar morphology; laser vaporization, while retaining good cosmetic results, is less effective in VIN treatment and does not allow evaluation of the surgical specimen.
Predicting the intention to use mobile banking in India

Purpose The purpose of this paper is to identify factors influencing the adoption of mobile banking in India and develop and empirically validate a model explaining the behavioural intention to use mobile banking in the Indian banking sector. Design/methodology/approach In this study, a model is developed and proposed to explain customers’ intention to use mobile banking. The model comprises six constructs, namely, perceived ease of use, computer self-efficacy, social influence, perceived financial cost, security, and trust. The model also describes the relationship between perceived ease of use and computer self-efficacy, as well as that between security and trust. The proposed model was tested by using a survey method, with a sample of 855 bank customers from public, private, foreign, and cooperative banks in India. Structural equation modelling analysis was performed with AMOS 16.0. Findings The proposed theoretical model was found to predict, with statistical significance, the intention to use mobile banking, explaining 76.9 per cent of the variance in the dependent variable. The results found that security, computer self-efficacy, perceived ease of use, and perceived financial cost, in that order of influence, affect customers’ intention to adopt mobile banking. Practical implications The results obtained will help both academic researchers and practitioners explain, understand, and elucidate the status of mobile banking in India, as well as helping them formulate strategies to expedite the use of mobile banking. Originality/value The adoption of mobile banking in India is in a nascent stage compared with developed countries such as the USA, the UK, and Finland, but it is expected to increase or surpass the rate of adoption of internet banking in those countries. Further, only limited research to date has examined the adoption of mobile banking in India, especially the drivers and inhibitors of mobile banking adoption.
EXAMINING A MODEL OF INFORMATION TECHNOLOGY ACCEPTANCE BY USERS OF ENTERPRISE RESOURCE PLANNING

Enterprise resource planning (ERP) system is a complex system that involves various stakeholders as users of ERP system within an organization. This research is the development of Hwang’s research (2005) who applies the implementation and adoption of ERP system in informal controls, such as self-control and cultural control. Perceived enjoyment as self-control and uncertainty avoidance as cultural control are used in the implementation of ERP systems and connected to technology acceptance variables for investigating the relationship between these variables. Field data taken through surveys of ERP system users in Indonesia (n=188) are analyzed by Amos. The results support the hypothesis of this research which shows that perceived enjoyment as self-control and uncertainty avoidance as cultural-control are important determinants of ERP system acceptance.
Dynamics of Entry and Exit of Product Varieties : – what evolution dynamics can account for the empirical regularities?

Firm-level heterogeneity is substantial even in narrowly defined industries. This paper focuses on formulating evolution dynamics which can account for the observed heterogeneity and its maintenance. Based on examination of data on Swedish firm’ supply pattern to different markets over time, we present a parsimonious model that has the ambition to capture the picture of heterogeneous firms, while accommodating the simultaneous exit and entry of destination varieties in firms’ supply pattern. The model assumes both scale economies of firms and path-dependence, where the latter is manifested in such a way that the arrival rate of innovation ideas to an individual firm is a function of each firm’s stock of varieties at every given point in time. The path-dependence phenomenon is an “explosive” non-linearity, whereas conservation mechanisms include development of demand and exit of established varieties. The described path dependence explains the skewed distribution of varieties across firms, but the question of what keeps the “equilibrium” away from competitive exclusion where only few large firms remain. We make use of simulations to depict and assess the innovation dynamics of the proposed model.
Arteriovenous graft placement in predialysis patients: a potential catheter-sparing strategy.

BACKGROUND When predialysis patients are deemed unsuitable candidates for an arteriovenous fistula, current guidelines recommend waiting until just before or after initiation of dialysis therapy before placing a graft. This strategy may increase catheter use when these patients start dialysis therapy. We compared the outcomes of patients whose grafts were placed before and after dialysis therapy initiation. STUDY DESIGN Retrospective analysis of a prospective computerized vascular access database. SETTING & PARTICIPANTS Patients with chronic kidney disease receiving their first arteriovenous graft (n = 248) at a large medical center. PREDICTOR Timing of graft placement (before or after initiation of dialysis therapy). OUTCOME & MEASUREMENTS Primary graft failure, cumulative graft survival, catheter dependence, and catheter-related bacteremia. RESULTS The first graft was placed predialysis in 62 patients and postdialysis in 186 patients. Primary graft failure was similar for pre- and postdialysis grafts (20% vs 24%; P = 0.5). Median cumulative graft survival was similar for pre- and postdialysis grafts (365 vs 414 days; HR, 1.22; 95% CI, 0.81-1.98; P = 0.3). Median duration of catheter dependence after graft placement in the postdialysis group was 48 days and was associated with 0.63 (95% CI, 0.48-0.79) episodes of catheter-related bacteremia per patient. LIMITATIONS Retrospective analysis, single medical center. CONCLUSION Grafts placed predialysis have primary failure rates and cumulative survival similar to those placed after starting dialysis therapy. However, postdialysis graft placement is associated with prolonged catheter dependence and frequent bacteremia. Predialysis graft placement may decrease catheter dependence and bacteremia in selected patients.
AN EXPLORATORY STUDY OF CHALLENGES FACED BY WOMEN ENTREPRENEURS IN THE CONSTRUCTION INDUSTRY IN SOUTH AFRICA

The potential of the South African economy to achieve desired growth is greatly hampered by the systematic exclusion of women entrepreneurial activity in the key industries that drive the economy. One such industry is the construction industry that contributes positively to the South African’s economy. Yet, this industry is highly male-dominated. Despite seeming improvements in women’s entrepreneurial participation in different industries, there is still a huge gap between the percentages of men and women participating in the construction industry, particularly from a small business perspective. The construction industry has remained largely closed to women entrepreneurs and posing overwhelming challenges to the few women who have found their way into the industry. This study explores these challenges faced by women entrepreneurs in the construction industry as well as the strategies adopted by these women to overcome some of the obstacles they encounter in the construction industry in Pietermaritzburg, South Africa. Qualitative data was collected using in-depth interviews from a sample of 16 women entrepreneurs. The snowball sampling technique was used to identify the participants. Content analysis was used for data analysis. The results revealed that women face deeply rooted socio-cultural challenges, particularly patriarchal attitudes in the construction industry. The strategies used by the women to overcome some of the challenges include partnering with male business owners when bidding for construction jobs and forming reliable business networks. It is, therefore, important for policy makers to engage more with women running small businesses in the construction industry in order to develop a deeper understanding of the nature of these challenges. Support should be tailor made to mitigate the specific challenges.
Molecular Phylogenetics and Patterns of Floral Evolution in the Ericales

The diverse and species‐rich order Ericales has found considerable interest among systematists in recent years. Molecular phylogenetic studies not only have convincingly demonstrated the monophyly of the order, comprising 23 families formerly placed in three different subclasses (Asteridae, Dilleniidae, and Rosidae), but have also resolved Ericales as sister to euasterids. Most ericalean families are well circumscribed and have been or are currently subject to intrafamilial phylogenetic studies. In spite of all the attention that Ericales have received recently, there remains a major challenge, the still largely unresolved deeper nodes in the ericalean phylogeny. This study aims to improve our current knowledge of the interfamilial relationships by expanding on gene and taxon sampling and to evaluate the evolution of important floral characters in light of the resulting phylogeny. We add a nuclear region (26s rDNA) to already published data sets (nuclear: 18s rDNA; mitochondrial: atp1, matR; chloroplast: atpB, ndhF, rbcL, matK, the rps16 intron, the trnT‐trnF spacer, and the trnV‐atpE spacer), for a total of 11 molecular markers that include nearly 20 kb of sequences. Our analyses, applying both maximum parsimony and Bayesian inference, resolve some of the deeper nodes in the phylogeny. Strongly supported groups, previously unrecognized or only weakly supported, include (1) a clade comprising all families except Balsaminaceae, Tetrameristaceae, Marcgraviaceae, Fouquieriaceae, Polemoniaceae, and Lecythidaceae; (2) a clade with Sapotaceae, Ebenaceae, and the primuloid families; (3) a clade with Symplocaceae, Styracaceae, and Diapensiaceae; and (4) a clade comprising the latter three families plus Theaceae, Roridulaceae, Actinidiaceae, Sarraceniaceae, Clethraceae, Cyrillaceae, and Ericaceae. At an analytical level, our results indicate that more data in the form of additional markers do improve resolution and branch support and should eventually lead to a fully resolved ericalean phylogeny. At the level of floral evolution, we demonstrate that sympetaly is a homoplasious character in the order, that a diplostemonous floral ground plan likely arose from haplostemonous flowers in Ericales, and that the combination of ovules with a single integument and cellular endosperm formation is characteristic for two of the major clades in the order.
Liaison between micro-organisms and oral cancer

Oral cancer which is a subtype of head and neck, cancer is any neoplastic tissue growth in the oral cavity. It comprises an abnormal mass of cells that foists genetic mutation and impedes the normal cell cycle, resulting in its unrestrained growth. Various studies on the plausible link between oral microbial flora and cancer notwithstanding, our understanding of their link remains obscure and inadequate. The multitude of mechanisms by which the microflora initiate or spur Carcinogenesis are still under study and scrutiny. As is widely known, the oral cavity is an abode to a wide assortment of microbes, each present in contrasting amounts. It is observed that increased growth of the microflora is concomitant with known clinical risk factors for oral cancer. Manifold bacterial species have been found to interfere directly with eukaryotic cellular signaling, adopting a style typical of tumor promoters. Bacteria are also known to impede apoptosis thereby potentially promoting carcinogenesis. The viral role in carcinogenesis (by annulling of p53 tumor suppressor gene and other cellular proteins with subsequent alteration in host genome function) is well documented. Furthermore, the changes occurring in the commensal microflora in accompaniment with cancer development could possibly be used as a diagnostic indicator for early cancer detection. The intention of this review is to obtain a better understanding of the “role” that micro-organisms play in oral cancer etiology.
GOVERNANCE IN FAMILY BUSINESS: EMPIRICAL STUDY IN BUS TRANSPORTATION INDUSTRY

How to cite this paper: Suseno, B. D. , Dwiatmadja, C. , & Yuniawan, A. (2017). This study aims to provide clear explanation and answer based on the research gap of previous studies that studied about the relationship between managerial trait from family business and managerial performance. also investigates the phenomenon about low managerial performance that triggered low continuity of bus industry belonged to family business in Indonesia. Justification of this research is the first research about manager from family in bus transportation the previous research conducted by related to succession of CEO leadership of family in batik industry in small scope in City of Pekalongan, Central Java. The model used for testing in this study is multivariate analyses with Structural Equation Model (SEM), which is based on AMOS program. The sample in this study is the manager that holds a position as supervisor and managerial controller of 505 persons. The number of samples is determined by proportion (%) of managers in the bus ownership industry. The questionnaires were distributed through direct distribution and by letter in June, July and August 2015. Of the distributed questionnaires, there are left 283 questionnaires. After being selected, there are 262 questionnaires that can be retested using SEM AMOS 22.0. Based on the result for 9 proposed hypotheses, there are 6 accepted hypotheses and 3 rejected ones. The accepted hypotheses are as follows: the influence of managerial trait in family business on soft governance capability which has coefficient value of 0.517 that shows positive and significant relationship since CR value is 2.705 and significant at 0.007, the influence of soft governance capability on managerial performance which has coefficient value as 0.506 that shows positive relationship since CR value is 6.183 and significant at 0.000. These results prove that soft governance capability has an ability to mediate the relationship between casualties of managerial trait variable on bus transportation industry in Jakarta, and it is significant with alpha value 5%
Antidiabetic Potential of Monoterpenes: A Case of Small Molecules Punching above Their Weight

Monoterpenes belong to the terpenoids class of natural products and are bio-synthesized through the mevalonic acid pathway. Their small molecular weight coupled with high non-polar nature make them the most abundant components of essential oils which are often considered to have some general antioxidant and antimicrobial effects at fairly high concentrations. These compounds are however reported to have antidiabetic effects in recent years. Thanks to the ingenious biosynthetic machinery of nature, they also display a fair degree of structural complexity/diversity for further consideration in structure-activity studies. In the present communication, the merit of monoterpenes as antidiabetic agents is scrutinized by assessing recent in vitro and in vivo studies reported in the scientific literature. Both the aglycones and glycosides of these compounds of rather small structural size appear to display antidiabetic along with antiobesity and lipid lowering effects. The diversity of these effects vis-à-vis their structures and mechanisms of actions are discussed. Some key pharmacological targets include the insulin signaling pathways and/or the associated PI3K-AKT (protein kinase B), peroxisome proliferator activated receptor-γ (PPARγ), glucose transporter-4 (GLUT4) and adenosine monophosphate-activated protein kinase (AMPK) pathways; proinflammatory cytokines and the NF-κB pathway; glycogenolysis and gluconeogenesis in the liver; glucagon-like-1 receptor (GLP-1R); among others.
ERYTHROCYTE VACUOLES IN HEREDITARY SPHEROCYTOSIS

3 10-3 1 3 . PRIEST, J.R. , RORINSON, r.i. MCKENNA. R.w. LINDOUJST, L.L. WASHENTIN, P.T. , LE BIEN. T.W. , WOODS. W.G. , KERSEY. J.H. , COCCIA, P.F. & NESBIT, M.E. ( 1980) Philadelphia chromosome positive childhood acute lymphoblastic leukemia. Blood, 56, 15-22. ROOZENDAAI. K.J., VAN DER RF.IJI)EN, H.J. & CERAEDTS, J.P.M. (198 1 ) Philadelphia chromosome positive acute lymphoblastic leukaemia with Tccll characteristic. British junrriul o ! Hwrnulo-
p63/p51-induced Onset of Keratinocyte Differentiation via the c-Jun N-terminal Kinase Pathway Is Counteracted by Keratinocyte Growth Factor*

p63/p51, a homolog of the tumor suppressor protein p53, is chiefly expressed in epithelial tissues, including the epidermis. p63 affects cell death similar to p53, and also plays important roles in the development of epithelial tissues and the maintenance of epithelial stem cells. Because it remains unclear how p63 regulates epithelial cell differentiation, we examined the function(s) of p63 in keratinocyte differentiation through the use of a keratinocyte culture system. ΔNp63α (ΔNp51B), a p63 isoform specifically expressed in basal keratinocytes, suppressed the differentiation of specific late-stage proteins, such as filaggrin and loricrin. In contrast, ΔNp63α induced keratin 1 (K1), which is expressed at the start of differentiation, via c-Jun N-terminal kinase (JNK)/AP-1 activation. However, p63 did not induce K1 expression in the basal layer in vivo, although basal keratinocytes had high levels of p63. This discrepancy was explained by the suppression of K1 expression by dermis-secreted keratinocyte growth factor. This suppression occurred via extracellular signal-related kinase (ERK) signaling, and counteracted the p63-mediated induction of K1. Thus, a precise balance between p63 and keratinocyte growth factor mediates the onset of epithelial cell differentiation, through JNK and ERK signaling. These data may provide mechanistic explanations for the pathological features of skin diseases, including psoriasis.
Racial/ethnic differences in bystander CPR in Los Angeles, California.

BACKGROUND Bystander CPR (BCPR) has been demonstrated to improve rates of return of spontaneous circulation, survival to hospital admission, and quality of life in survivors. While previous studies have shown that African Americans are less likely to receive BCPR than Caucasians even after adjusting for variables such as socioeconomic status, BCPR rates in Latinos have not been reported. OBJECTIVE To describe BCPR rates in an urban African American and Latino population as compared to Caucasians. METHODS A retrospective analysis of the Cardiac Arrest Resuscitation Evaluation in Los Angeles (CARE-LA) database combined with the California Death Statistical Master File (CDSMF). The combined database included location, race/ethnicity/ethnic background, witnessed status, socioeconomic status, and other variables that have previously been associated with differing rates of BCPR. RESULTS There were 814 individuals included in the final study group (53% Caucasian, 28% African American, 19% Latino). African Americans and Latinos were younger than the Caucasians, had more events in the home and had a bystander CPR rate of 13% compared to 24% for the Caucasians (OR=0.47 (95%CI: 0.30-0.74) for African Americans and OR=0.48 (95%CI:0.28-0.80) for the Latinos). Bystander CPR was found to be an independent predictor of survival to hospital discharge and, after adjustment, Latino ethnicity was associated with lower rates of bystander CPR (OR 0.45 (95%CI:0.22-0.92)). CONCLUSION After adjusting for other variables, Latinos in Los Angeles receive bystander CPR at approximately half the rate of Caucasians.
Early adhesive behavior of bone-marrow-derived mesenchymal stem cells on collagen electrospun fibers

A bioabsorbable nanofibrous scaffold was developed for early adhesion of mesenchymal stem cells (MSCs). Collagen nanofibers with diameters of 430 ± 170 nm were fabricated by electrospinning. Over 45% of the MSC population adhered to this collagen nanofiber after 30 min at room temperature. Remarkably, collagen-coated P(LLA-CL) electrospun nanofibers were almost as efficient as collagen nanofibers whereas collagen cast film did not enhance early capture when it was applied on cover slips. The adhesive efficiency could be further increased to over 20% at 20 min and over 55% at 30 min when collagen nanofibers were grafted with monoclonal antibodies recognizing CD29 or CD49a. These data demonstrate that the early adhesive behavior is highly dependent on both the surface texture and the surface chemistry of the substrate. These findings have potential applications for early capture of MSCs in an ex vivo setting under time constraints such as in a surgical setting.