Miracle-dz/UniFAR-FTUs huggingface dataset:
THE FRITZ HABER INSTITUTE THZ FEL STATUS

The Fritz Haber Institute (FHI) of the Max Planck Society in Berlin, Germany [1], will celebrate its Centennial in 2011. Coincident with this event, the Department of Molecular Physics will christen a THz Free Electron Laser (FEL) that will operate from 3 to 300 microns. A linac, with a gridded thermionic gun, is required to operate from 20 to 50 MeV at 200 pC, while delivering a transverse rms emittance of 20 mm-mrad in a 1 psec rms, 50 keV rms energy spread bunch at the wigglers. Mid-IR and Far-IR wigglers enable this electron beam to deliver the required radiation spectrum. In addition to the longitudinal emittance, a key design requirement is the minimization of the micropulse and macropulse jitter to ensure radiation wavelength stability and timing consistency for pump probe experiments. We present the completed conceptual and engineering design that delivers the required performance for this device and summarize the status of fabrication. Shipment is scheduled for early in the new year with first light targeted for October 201
Combining RPL27 with OAZ1 or RPL8 as Universal Normalizers of Gene Expression in Canine Endometrial Studies

Background: The canine endometrium represents a complex, heterogeneous tissue with several cell populations featuring divergent gene expression patterns that become of high interest during cyclic hormonal stimulation, or in response to pathogen-activated immunological activation like in the case of pyometra. Assuming that reference gene expression stability is not shared between the different endometrial cell types, a whole tissue-based approach may not be adequate. Dependable qRT-PCR quantiﬁ cation of endo- or exogenously induced transcript me changes is primarily reinforced by normalisation with reference genes. Thorough evaluation of these endogenous controls is important, but has so far been insufﬁ ciently addressed, especially in reproductive veterinary medicine. Often, reference gene selection relies on results obtained with other species, or considers only tissue and not cell-speciﬁ c results. Results: We evaluated the stability of nine putative reference genes in healthy and pyometra-affected canine uterine tissue homogenates, and the respective endometrial cell types. For cell-speciﬁ c analysis endometrial stromal and epithelial cells were either isolated via Laser-Capture Micro dissection (LCM) from tissue cryo sections or cultivated under hormonal stimulation in vitro . While single-gene stability ranking did not present a universal solution, the inclusion of arbitrary normalizers composed of the geometric mean of paired genes computed by group-speciﬁ c Norm Finder analysis showed that using RPL27 combined with either RPL8 or OAZ1 resulted in remarkable stability values. Both arbitrary reference genes were top-ranked in the tissue and cell culture data sets, and were useful especially for the highly variable LCM samples. Conclusion: The combination of RPL27 with either RPL8 or OAZ1 was successfully identiﬁ ed as best working normalizer in gene expression data acquisition of different sample types of the canine endometrium.
Intraspecific Variation in Plant-Plant Interactions and Belowground Zone of Influence of Big Sagebrush ( Artemisia tridentata )

iv LIST OF TABLES . viii LIST OF FIGURES . ix CHAPTER ONE: INTRASPECIFIC VARIATION IN PLANT-PLANT INTERACTIONS OF BIG SAGEBRUSH . 1 Abstract . 1.
AN EMPIRICAL ANALYSIS OF CAPITAL STRUCTURE DECISIONS IN MALAYSIAN LISTED COMPANIES

Capital structure is one of the most important tasks to be fulfilled by financial managers in order to maintain the sustainability of the firms in the long run. In fact, the search for optimal capital structured has dominated the theory of capital structure. However, is there an optimal capital structure in reality? An optimal capital structure can be described as the best debt to equity ratio for the firm in which this will minimizes the cost of financing and maximizes the value of the firm. Thus, financial managers should always choose between debt and equity financing which will be more beneficial to the company. Choosing on the best source of finance also related to the minimizing the tax liability of the company. This is due to the fact that in trade-off theory, interest on debt is taxdeductible which resulted to the lower cost of financing. However, this is not always the case if the debt is used not in the production of gross income.
Co-Use of Tobacco and Alcohol , the School-Specific Tobacco-Alcohol Use Association , and the 5 HTTLPR Gene

Background. Previous research shows that school health behavioral environments and genetic influences are important determinants of tobacco and alcohol use separately. Very little is known about patterns of tobacco and alcohol co-use in adolescence and young adulthood and how genetic and environmental influences interact to predict risk. This is particularly important because co-use has substantially greater negative health effects than tobacco or alcohol use alone. Methods. We use four waves of data from the National Longitudinal Study of Adolescent Health (Add Health; n = 10,034) to describe patterns of tobacco and alcohol co-use from adolescence through adulthood. We predict co-use profiles by combining rich information about the co-use environment (school-specific co-use) with genetic information from the respondents ((5HTTLPR). Pooled analyses of the odds of couse were modeled using logistic regression as an interactive function of the school health behavioral environment and genotype. Finally, sibling fixed effects models of a continuous measure of co-use were used to provide a maximally stringent test of this hypothesis. Results. The interaction of 5HTTLPR and school-level tobacco and alcohol use association is positively associated with the odds of tobacco and alcohol co-use in longitudinal analyses. In sibling fixed effects models, this finding is confirmed. Conclusion. The prediction of the differential susceptibility hypothesis of interactions between the 5HTTLPR gene and the school health behavioral environment is confirmed. Word Count: 2,832
Recognition of Good, Bad, and Neutral News Headlines in Portuguese

This paper investigates the classification of news headlines as positive, negative, and neutral. A news headline is positive if is associated with good things, negative if it is associated with bad things, and neutral in the remaining cases. The classification of a news headline is predicted using a supervised approach. The experiments show an accuracy that ranges from 59.00% to 63.50% when argument1-verb-argument2 relations are combined with other features. The accuracy ranges from 57.50% to 62.5% when these relations are not used.
Efficacy of Routine Fecal Microbiota Transplantation for Treatment of Recurrent Clostridium difficile Infection: A Retrospective Cohort Study

Background Patients with recurrent Clostridium difficile infections (CDIs) constitute an increasing treatment problem. Fecal microbiota transplantation (FMT) has shown promising results of treating recurrent CDI, where treatment with antibiotics fails repeatedly. Our study describes retrospective cohort treated with FMT at two major hospitals in Stockholm. Methods Medical records of all patients with recurrent CDI treated with FMT during the period 2013–2017 were reviewed. We evaluated cure of CDI-related diarrhea without relapse 10 weeks after FMT. Results 47 patients were included. One treatment cured 25 patients (53%), and more than one treatment cured 32 patients (68%). Treatment outcome did not vary significantly with treatment with fresh donor feces or frozen fecal culture, days of use of antibiotics or days of hospitalization prior to CDI, and renal function or time from the first CDI to therapy. Treatment failure was associated with a significantly lower Karnofsky performance status score (70 points vs 90, p=0.02). Conclusion Fecal instillation, for the treatment of relapsing CDI, is a promising approach, with 68% success rate reported in this study. The success rate of FMT is high, regardless of multiple comorbidities, extended use of antibiotics, or long time hospitalization. Although generally FMT is performed with fresh donor feces, our data show that the usage of frozen fecal culture could be an effective treatment alternative in recurrent CDI.
Spray-Drying Performance and Thermal Stability of L-ascorbic Acid Microencapsulated with Sodium Alginate and Gum Arabic

The potential of sodium alginate (ALG) and gum arabic (GA) as wall polymers for L-ascorbic acid (AA) encapsulation as a tool for their preservation against the thermo-oxidative degradation was investigated. The influence of such polymers used as wall material on the AA-content, size, encapsulation efficiency, encapsulation yield and thermo-oxidative stability were evaluated. The AA-microparticles were obtained using the spray-drying technique. An experimental Taguchi design was employed to assess the influence of the variables in the encapsulation process. The microparticles morphology and size distribution were characterized by scanning electron microscopy and laser diffraction. The thermal stability of AA microparticles was studied by differential scanning calorimetry and thermogravimetry analysis. This work points out the viability to encapsulate AA using GA and ALG through a spray-drying process. In general, a product yield ranging from 35.1% to 83.2% and an encapsulation efficiency above 90% were reached. Spherical microparticles with a smooth surface were obtained with a mean diameter around 6 μm and 9 μm for the those prepared with GA and ALG, respectively. The thermo-oxidative analysis showed that both polymers allow maintaining AA stable up to 188 °C, which is higher than the traditional processing temperature used in the fish feed industry.
Optimal Commodity Advertising in Bilateral

This study derives an optimal commodity advertising intensity rule for a vertically related market under bilateral oligopoly. The new optimality condition derived in this study extends the seminal Dorfman-Steiner Theorem [1] and recently published optimal advertising conditions by two major aspects. First, we strengthen the previous work by considering potential market power exertion in all buying (input) and selling (output) markets, i.e., all four adjacent upstream and downstream markets of processors and retailers. Second, we use a primal production function approach to avoid the symmetry assumption that many earlier studies imposed on conjectural elasticities of input and/or output markets. Our new condition suggests that, without considering the potential market power exertions, the optimal advertising intensity and expenditures are overestimated. Our derivation also indicates that previous optimal advertising conditions derived under the assumption of fixed proportion technology could underestimate the optimal intensity and expenditures, particularly when advertising elasticity is elastic.
ESTIMATION OF DEMAND FOR MORTGAGE LOANS USING LOAN-LEVEL DATA

This report contains structural and econometric model for estimating the demand on mortgage loans. The demand for loan can be represented as two functions: probability of borrowing and the loan amount depending on borrowerspecific characteristics, contract terms and set of macrovariables. The decisionmaking process on borrowing can be described as the sequence of decisions on: 1) choosing the credit program; 2) approving of a borrower; 3) choosing contract terms from feasible set; 4) and loan performance. Following Attanasio, Goldberg and Kyriazidou (2008) and Philips and Yezer (1996) the author proposes the econometric approach that deals with endogeneity and self-selection of borrowers when estimating the demand-for-loan equations and specifies the structure of data that is required for implementation of that approach.
The Theory of Planned Behavior: The Role of Descriptive Norms and Habit in the Prediction of Inter-city Travel Mode Choice

This paper makes use of a sample of travelers in metropolitan area of Yangtze River Delta to compare psychological predictors of the intention to use four travel modes: the traditional train, the Electric Multiple Unit (EMU), the High Speed Railway (HSR), and the coach. An expanded version of the Theory of Planned Behavior (TPB) containing separate measures of social norms and habit is employed. The results demonstrate that attitude, subjective norm, and perceived behavioral control explained between 33% and 45% of the variance in intention to use various travel modes. In all cases, attitude and subjective norm are important factors and by adding descriptive norm to the original predictors in TPB, the explained variance increased by between 4% and 8%. Furthermore, introduction of habit in model results the much more explained variance in intention. This paper also reports the study which demonstrates the moderating effect of habit on the intention–behavior relationship. Results illustrate that the effect of habit as moderator of intention on behavior in intercity travel modes was weaker than that in in-city travel modes.
Functional tag SNPs inside the DRD2 gene as a genetic risk factor for major depressive disorder in the Chinese Han population.

BACKGROUND The D2 dopamine receptor (DRD2) has been extensively investigated and has been associated with the occurrence of neuropsychiatric disorders. Polymorphisms in the DRD2 gene have also been determined as a possible predisposing component for major depressive disorders (MDD). The present study focused on evaluating the connection of polymorphisms inside the whole DRD2 gene in MDD patients as well as in non-MDD participants in a group selected from the Chinese Han population. MATERIALS AND METHODS In total, 831 unrelated Chinese adults from the Han population were sampled, including 497 non-MDD participants and 334 MDD patients for this evaluation. After the haplotype bins were built, 14 tag single-nucleotide polymorphisms (tSNPs) and the two most investigated SNP were chosen for the whole DRD2 gene. An improved multiplex ligation detection reaction (iMLDR) technique was used to choose the genotypes. Following this, the allelic frequencies and clinical features were contrasted between the two independent Chinese Han populations. Transcriptional enhancer activities were measured to assess the functionality of the rs7131056 polymorphism. RESULTS Sixteen SNPs were identified, including the two most examined in the Chinese Han population, and all were recurrent SNPs. Of the 16 SNPs, two (rs4648317 and rs7131056) were significantly connected to MDD. Patients with MDD were more apt to carry the rs4648317G and rs7131056A allele in contrast to the non-MDD controls (P < 0.05). The genetic risk effect on MDD occurrence was associated with the haplotype GTGATCGCGCAGGC of fourteen tag SNPs (OR = 1.52, 95% CI: 1.06 to 2.18, P = 0.02). Moreover, the rs7131056 polymorphism contained intronic silencer activities. CONCLUSIONS This case-control evaluation involving the Chinese Han population suggests that the rs4648317 and rs7131056 polymorphisms and the haplotype GTGATCGCGCAGGC inside the DRD2 gene could be possible markers to forecast vulnerability to MDD.
Cigarette Smoke Induced Lung Barrier Dysfunction, EMT, and Tissue Remodeling: A Possible Link between COPD and Lung Cancer

Chronic obstructive pulmonary disease (COPD) and lung cancer, closely related to smoking, are major lung diseases affecting millions of individuals worldwide. The generated gas mixture of smoking is proved to contain about 4,500 components such as carbon monoxide, nicotine, oxidants, fine particulate matter, and aldehydes. These components were considered to be the principle factor driving the pathogenesis and progression of pulmonary disease. A large proportion of lung cancer patients showed a history of COPD, which demonstrated that there might be a close relationship between COPD and lung cancer. In the early stages of smoking, lung barrier provoked protective response and DNA repair are likely to suppress these changes to a certain extent. In the presence of long-term smoking exposure, these mechanisms seem to be malfunctioned and lead to disease progression. The infiltration of inflammatory cells to mucosa, submucosa, and glandular tissue caused by inhaled cigarette smoke is responsible for the destruction of matrix, blood supply shortage, and epithelial cell death. Conversely, cancer cells have the capacity to modulate the proliferation of epithelial cells and produce of new vascular networks. Comprehension understanding of mechanisms responsible for both pathologies is necessary for the prevention and treatment of COPD and lung cancer. In this review, we will summarize related articles and give a glance of possible mechanism between cigarette smoking induced COPD and lung cancer.
Correlation Between ECG Changes and 2D Speckle Tracking Echocardiography with Coronary Angiography in Non-ST Segment Elevation Myocardial Infarction Patients

The clinical presentation of acute coronary syndrome is variable Patients with suspected NSTEACS are a heterogeneous group. Coronary occlusion may or may not be present. To correlate 2D speckle tracking echocardiography with coronary angiography results in non-ST segment elevation myocardial infarction patients and test its ability to predict culprit lesion. It is a prospective study where 100 patients with non-ST elevation myocardial infarction were enrolled in the study where regional wall motion score index was obtained by echocardiography then 2D speckle tracking echocardiography was done and territorial longitudinal strain for each vessel was obtained and finally coronary angiography was done. By using the bull’s eye view of the territorial LS values obtained from the 17 myocardial segments to predict the culprit artery for each patient the sensitivity for prediction of culprit LAD was 93.3 %, specificity was 92.7 %, For LCX; sensitivity was 82.7 %, specificity was 92.9 % and for RCA; sensitivity was 84 %, specificity was 93.3 %. Longitudinal strain imaging by 2D speckle-tracking might help in the work-up of nonST elevation myocardial infarction patients. In addition, it may be helpful to localize coronary artery stenosis in a given perfusion territory.
A Cross-Level Perspective on Creativity : The Role of Learning Goal Orientation , Work Engagement , and Organizational Learning Climate

Creativity is becoming increasingly vital to organizations in the context of ever-changing environment. This study integrated goal orientation theory, social cognitive theory and personenvironment fit theory to construct the impact model of individual learning goal orientation and creativity, as well as discussed the effects of work engagement and organizational learning climate in their relationship. Using regression and hierarchical linear modeling methods, a sample of 765 employees nested in 30 organizations from China was empirically tested. Results indicate that learning goal orientation was positively related to creativity, work engagement partly mediated the relationship between learning goal orientation and creativity, and organizational learning climate had a positive cross-level moderating effect in the relationship of individual learning goal orientation and work engagement. This study also illustrated the contributions to the theory development and practical implications for managers.
EVALUATION OF BOTANICAL EXTRACTS FOR THE MANAGEMENT OF BRANCH CANKER DISEASE (MACROPHOMA Sp) IN TEA

Branch canker is a stem disease of tea caused by Macrophoma theicola. The antifungal activity of aqueous extract of Acrous calamus was found to fully inhibit growth of Macrophoma sp. at 10 percent concentration. While the plant extracts of Curcuma longa and Hibiscus rosasinensis showed good results. The inhibitory potential of Psidium guajava and Allamanda cathartica indicated significant effect at 15% concentrations followed by Murraya koenigii, Azadirachta indica and Artemisia nilagirica. Moderate inhibition was noticed by Carica papaya extracts followed by action of Cinnamomum burmannii and Dryopteris linearis extracts. The extracts of Tithonia diversifolia, Conyza ambigua and Adhatoda vasica level at 10% showed lowest control potential.
Strategic Guideline For Nurses ’ Performance Regarding Preventing Catheter-Associated Urinary Tract Infections At Intensive Care Units 1

Catheter-associated urinary tract infections (CAUTIs) are the most common health care–associated infections in the intensive care units. Aim: To evaluate the effect of strategic guideline on nurses’ performance regarding preventing catheter-associated urinary tract infections at intensive care units. Subjects and Methods: Design: A quasi experimental research design was used to conduct this study. Setting: The study was carried out at pediatrics and adults intensive care units in Beni-Suef University Hospital, General Hospital and Health Insurance Hospital in Beni-Suef Governorate. Sample: A purposive sample was selected and composed of 100 nurses. Tools: Three tools were used in this study: First tool: A self-administered questionnaire to assess nurses’ socio-demographic characteristics and knowledge regarding CAUTIs and strategic guideline to prevent catheter-associated urinary tract infections in intensive care units. Second tool: Nurses attitude (Likert scale): To assess nurse's attitudes regarding prevention of CAUTls. Third tool: Observational checklists to assess nurses’ practices(catheter insertion and strategic guideline to prevent catheter-associated urinary tract infections) through guideline phases (pre/immediately post and at follow up). Results: For 35% of the studied nurses their age ranged between 25-30 years or more with a mean age of 24.68±4.33, 52% of the them had secondary nursing education, and there was a highly statistically significant difference (P<.0001), regarding their knowledge, attitudes and practices before, immediately after, and at follow up guideline implementation toward preventing catheter-associated urinary tract infections. Conclusion: This study proved that the strategic guideline had significant effect on improving nurses’ performance regarding preventing of catheter-associated urinary tract infections at intensive care units. Recommendations: Publication and dissemination of the strategic guideline in all health service departments and ICUs to improve nurses’ performance about the care of urinary catheter and prevention of CAUTIs for adults and children.
miR-143 inhibits migration and invasion through regulating LASP1 in human esophageal cancer.

BACKGROUND Esophageal cancer (EC) is one of the common cancers in China with high incidence and poor prognosis. Increasing evidence has emphasized the important roles of differentially expressed miRNAs in esophageal squamous cell carcinoma (ESCC) progression. Previous studies indicated that miR-143-3p and LASP1 influence cell growth in ESCC and other cancer types. However, the function and molecular mechanism of action of miR-143 and LASP1 in ESCC have not been fully explored. METHODS miR-143 and LASP1 expression were detected by quantitative real-time PCR. The protein level of LASP1 was measured by western blot. Cell proliferation was evaluated by MTT assay. Cell migration and invasion capacity was measured by transwell assay. Targeting of LASP1 mRNA by miR-143 was verified by luciferase reporter assay. Overall survival of ESCC patients with different miR-143 expression level was evaluated by Kaplan-Meier survival analysis. RESULTS miR-143 expression was down-regulated, while LASP1 expression was up-regulated in ESCC tissues and cells compared to non-malignant counterparts. LASP1 mRNA was identified as a target of miR-143. Low miR-143 expression or high LASP1 expression significantly associated with ESCC patients' decreased survival. miR-143 mimic transfection inhibited ESCC cell proliferation, migration and invasion in vitro, which was impaired by LASP1 overexpression. CONCLUSION miR-143 suppressed cell proliferation, migration, and invasion by down-regulating LASP1.