Miracle-dz/UniFAR-FTUs huggingface dataset:
EXPRESSION OF ELASTASE ON POLYMORPHONUCLEAR NEUTROPHILS in vitro AND in vivo: IDENTIFICATION OF CD11B AS LIGAND FOR THE SURFACE-BOUND ELASTASE

Elastase is a major serine protease of polymorphonuclear neutrophils (PMN). On activation of PMN, the preformed protein is mobilized from intracellular stores and, depending on the activating conditions, is either released into the supernatant or is bound to the cell surface. By a variety of methods, including uptake and crosslink studies, as well as confocal laser scan microscopy, we now provide evidence that elastase binds to the β2-integrin CD11b and induces a conformational alteration of CD11b, apparent as expression of a neodeterminant. Similarly to the in vitro data, elastase surface expression and conformational alterations of CD11b were seen on PMN of patients with Staphylococcus aureus-induced localized infection, particularly on PMNs recovered from the infected site. The presence of elastase at the site of inflammation is in keeping with its presumed role in leukocyte trafficking and host defense. On the other hand, because of its potential for degrading extracellular matrix proteins, elastase could participate in localized tissue damage as it occurs in severe S. aureus infection.
Leveraging data rich environments using marketing analytics

With the onset of what is popularly known as “big data”, increased attention is being paid to creating value from these data rich environments. Within the field of marketing, the analysis of customer and market data supported by models is known as marketing analytics. The goal of these analyses is to enhance managerial decision making regarding marketing problems. However, before these data rich environments can be used to guide managerial decision making, firms need to grasp the process of doing so. Therefore, in this thesis we explore two opportunities and one challenge that firms are faced with in this process. The first opportunity we identify is the possibility to get enhanced insights on own and competitors’ market behavior. Here, the difference in reactions to competing strategic and tactical marketing actions is investigated, in order to improve future decision making in the face of competitive response. The second opportunity identified is the possibility to engage in real-time marketing. Using ideas from statistical quality control, a control chart method to track customer purchase behavior is developed. Using this approach, firms can decide what the best time to approach a customer with a marketing action is, increasing the relevance and effectiveness of such actions. The challenge investigated is that of maintaining customer privacy when using marketing analytics. In the setting of customer churn prediction, it is shown that firms can still perform effective analyses of customer churn while maintaining customer privacy. The method developed in this chapter assures this.
Ef fi cacy and Safety of Thrombin-Receptor Antagonist ( Atopaxar and Vorapaxar ) in Patients with Acute Coronary Syndrome or Coronary Artery Disease — A Meta-Analysis of Randomized Controlled Trials

Background: Meta-analysis for the efficacy and safety data of thrombin-receptor antagonist (TRA) based on patients with acute coronary syndrome (ACS) or coronary artery disease (CAD) and indirect comparisons between TRAs were not available. Objectives: We intended to synthesize the primary end points based on different patient populations (ACS or CAD) as well as perform indirect comparison between two newly invented antiplatelet agents atopaxar and vorapaxar. Methods: A literature search was performed in MEDLINE, Embase, and Cochrane Library. Incidences of major adverse cardiovascular events (MACEs) and bleeding events according to thrombolysis in myocardial infarction were selected as primary outcomes, whereas adverse effects were considered as secondary outcomes. Corresponding results were synthesized using Revman 5.1 according to ACS or CAD cohorts. Results: Among the seven included randomized controlled trials, the efficacy end points in the TRA treatment group were favorable compared with placebo. Specifically, the odds ratio (OR) of MACEs was 0.80 (95% confidence interval [CI] 0.52–1.22) for patients with ACS and ee front matter Copyright & 2015, International S
Regression testing minimization, selection and prioritization: a survey

Regression testing is a testing activity that is performed to provide confidence that changes do not harm the existing behaviour of the software. Test suites tend to grow in size as software evolves, often making it too costly to execute entire test suites. A number of different approaches have been studied to maximize the value of the accrued test suite: minimization, selection and prioritization. Test suite minimization seeks to eliminate redundant test cases in order to reduce the number of tests to run. Test case selection seeks to identify the test cases that are relevant to some set of recent changes. Test case prioritization seeks to order test cases in such a way that early fault detection is maximized. This paper surveys each area of minimization, selection and prioritization technique and discusses open problems and potential directions for future research. Copyright © 2010 John Wiley & Sons, Ltd.
COMPETITIVENESS OF FOOD AGRO-INDUSTRIAL MSMEs: ROLE OF BUSINESS MANAGEMENT AND GOVERNMENT POLICY

Micro, Small and Medium Enterprises (MSMEs) are the business Group that become important part in the development of the national economy, and also as strategic sector for the nation of Indonesia. The increasing of the number MSMEs is not accompanied by an increase the quality and competitiveness to face the competition from other MSMEs, many factor which influenced toward the increased of performance and competitiveness should come first, as well as reduce the problems that become obstacles the development MSMEs. The problems faced by MSMEs in Malang Regency including managerial aspect to managed business and government policies that have not fully give benefit for micro and macro business. The purpose of this research is to analyze influence of business management variables (X1) and government policies (X2) on the performance (Y1) competitiveness (Y2) food agro industrial MSMEs in Malang. The research used Partial Least Square (PLS) method to analyzing the data. Respondents of this study are 30 MSMEs, who were taken using purposive sampling technique. The results showed that the variables of business management not significant effect on performance and significant effect on the competitiveness of MSMEs. Government policies have a significant effect on the performance of MSMEs and not significant effect on competitiveness. Performance of MSMEs has a significant effect on competitiveness. Variable business management provides the strongest direct influence on the competitiveness of MSMEs.
ff ects of Radiation on 1 / f Noise in Complementary ( npn + pnp ) SiGe HBTs

We present the first study of the effects of radiation on lowfrequency noise in a complementary (npn + pnp) SiGe HBT BiCMOS technology. In order to manipulate the physical noise sources in these complementary SiGe HBTs, 63.3 MeV protons were used to generate additional (potentially noise-sensitive) traps states. The base currents of both the npn and pnp SiGe HBTs degrade with increasing proton fluence, as expected, although in general more strongly for the npn transistors than for the pnp transistors, particularly in inverse mode. For the pnp SiGe HBTs, irradiation has almost no effect on the 1/f noise to proton fluences as high as 5.0×1013p/cm2, while the npn SiGe HBTs show substantial radiation-induced excess noise. In addition, unlike for the pnp devices, which maintain an I2 B bias dependence, the 1/f noise of the post-irradiated npn SiGe HBTs change to a near-linear dependence on IB at low base currents following radiation, suggesting a fundamental difference in the noise physics between the two types of devices.
THE ANTECEDENTS OF ORGANIZATIONAL AGILITY: ORGANIZATIONAL STRUCTURE, DYNAMIC CAPABILITIES AND CUSTOMER ORIENTATION

This study aims to investigate some antecedents of organizational agility. In the literature, it is seen that studies suggest that some organizational factors provide to maintain organizational agility. Therefore, organizational structure, dynamic capabilities and customer orientation are considered as predictors of organizational agility within the scope of the study. For this purpose, the data which were collected from 176 employees in the retailing industry by the survey method were analyzed using the structural equation modeling. The results of the study indicate that two dimension of dynamic capabilities which are addressed as integration and coordinating have a positive and significant effect on organizational agility. However, organic and mechanic organizational structures have no significant effect on organizational agility. In addition, customer orientation levels have a positive and significant effect on organizational agility.
Digital Marketing Strategy: An Integrated Approach to Online Marketin

The modern marketer needs to learn how to employ strategic thinking alongside the use of digital media to deliver measurable and accountable business success. Digital Marketing Strategy covers the essential elements of achieving exactly this by guiding you through every step of creating your perfect digital marketing strategy. It contains analysis of the essential techniques and platforms of digital marketing including social media, content marketing, SEO, user experience, personalization, display advertising and CRM, as well as the broader aspects of implementation including planning, integration with overall company aims and presenting to decision makers. Simon Kingsnorth brings digital marketing strategy to life through best practice case studies, illustrations, checklists and summaries, to give you insightful and practical guidance. Rather than presenting a restrictive 'one size fits all' model, this book gives you the tools to tailor-make your own strategy according to your unique business needs and demonstrates how an integrated and holistic approach to marketing leads to greater success.
Open Innovation Practices in the Professional Services Industry

Open innovation (OI) has become a very popular topic both in academic and professional services. Peer-reviewed articles have proliferated, researchers have been increasingly studying OI, and the professional world has been investing in it. The interest is there and growing. From an academic perspective, most of the focus have thus far been on manufacturing and technology sectors, with less emphasis on services. Through an extensive review of the literature, a growing trend of focus on services in open innovation is observed, with an increasing amount of empirical studies conducted in recent years. However, professional services firms (PSFs e.g. accounting, tax, consulting, deals, and engineering services) are very lightly covered thus far. They play an important role as integrators, intermediaries and catalysts of innovation in the ecosystem, making them theoretically more inclusive and open by nature. This makes them an interesting field of study for OI. Given this important gap, the objective of this thesis is to better understand open innovation in PSFs, its applications and impacts on performance. To contribute in closing this gap, a conceptual model integrating all OI building blocks was developed based on the non-services literature review. This model was then expanded to account for the particularities of services and PSFs in particular. This was accomplished through another literature review and an exploratory research (20 interviews) in several PSFs and some of their clients in Canada. The revised model and propositions were then tested through a survey in one of the largest professional services firm in Canada (5,000-10,000 employees), with 345 respondents. In parallel, the survey was also opened to a larger set of companies in the sector to validate the findings externally, with another 55 external respondents. Finally, four leaders in the industry were interviewed to get their feedback and insights on the results. On site observations confirmed that professional services apply several of the open innovation practices brought forward in the theory. Collaborating with external partners, sourcing knowledge and innovations from outside the firm boundaries, sharing internal knowledge and innovations openly with the public and the customers all key activities that professional services conduct regularly. The nature of their work, very geared towards value creation through knowledge creation and transfer to clients in particular, makes PSFs more inclined to engage in open innovation practices. The current research proved that Open innovation is applicable in professional services firms, with certain particularities. Outside-in is more important than inside-
The Rhetoric and Reality of Trade Liberalisation in Developing Countries

The paper reviews the evidence of the impact of trade liberalisation on the economic performance of poor developing countries with respect to trade and the balance of payments, economic growth, poverty reduction, the distribution of income within countries, and the distribution of income between countries, and finds that trade liberalisation has not delivered the benefits expected. Economic theory, and the historical and contemporary evidence, all provide arguments for protection of industrial activities in developing countries.
International new ventures market expansion through collaborative entry modes

Purpose The purpose of this paper is to examine the role that different collaborative entry modes play in how international new ventures (INVs) expand into international markets. Design/methodology/approach The paper’s arguments are based on the INVs and social network literatures. In order to investigate the entry modes adopted by British and Indian small and medium information and communication technology (ICT) firms into each other’s markets, the paper outlines the results of qualitative semi-structured interviews with the key decision makers of ten British and ten Indian ICT firms. Findings The findings contribute to the relatively under-researched area of how INVs enter foreign markets through collaborative entry mode. The findings suggest that INVs utilize both equity and non-equity modes of collaboration to expand their international operations. The findings also indicate that financial and non-financial resources always limit the market expansion and internationalization of such companies. Against this background, the INVs rely on building collaboration as one of the safest methods for foreign market expansion and successful internationalization. The collaborative entry mode is enhanced by entrepreneurs’ prior experience, social ties and knowledge of the foreign market. Research limitations/implications Set against the backdrop of an ever-increasing trend of internationalization of small and medium enterprises (SMEs), the paper offers important implications for understanding the conditions and factors behind the choice of collaborative and non-collaborative entry modes by INVs in particular and SMEs more broadly. Originality/value The paper is one of the few studies that have examined the role of collaborative entry modes choice adopted by INVs from two of the largest economies – the UK and India.
The Changing Landscape of Auditor Litigation

We provide a comprehensive overview of shareholder litigation against auditors since the passage of the PSLRA. The number of lawsuits per year has declined, dismissals have increased, and settlements in recent years have declined. Our study asks why. Because we find that the likelihood an auditor is sued following a severe restatement has significantly declined in recent years, it does not appear that the decline can be attributed solely to increases in audit quality. Instead, we consider whether the Supreme Court cases limiting the scope of Rule 10b-5 against private actors may have led to the decline. To study this possibility, we focus on the Supreme Court’s 2007 and 2011 rulings in Tellabs v. Makor and Janus v. First Derivative, respectively. Our analysis provides strong evidence that the higher liability standards imposed by Janus significantly reduced auditors’ liability exposure, but we find only limited evidence that the pleading standard imposed by Tellabs had a significant effect.
Valuing IPOs using pro forma financials in the prospectus

Are pro forma financial statements as required by SEC Regulation S-X Article 11 informative? Do investors incorporate this information into stock prices? To test these questions, I perform valuation-relevance analysis on an IPO sample from 1997 to 2007. I focus on the IPO prospectus because it provides pro forma financial statements that are not available from other sources; other SEC filings (e.g., 8-Ks, 10-Ks) provide pro forma financial statements that might be accessed by investors from other sources (e.g., company websites, press releases), making interpretation of valuation-relevance analysis results difficult. I find that while future long-term earnings are correlated with pro forma earnings adjustments, IPO stock prices are not. I also find that pro forma earnings adjustments are able to predict post-IPO stock returns. Collectively, my findings suggest that investors fail to fully extract future earnings information captured by pro forma earnings adjustments in the IPO prospectus.
Morphosemantic Analysis and Translation of Medical Compound Terms

This paper describes an automatic procedure for morphosemantic analysis and translation of compound medical terms. This analysis is of interest for the automatic indexation of medical discharge reports and summaries. Since words with the suffix -osis may have many different semantic interpretations, such -osis forms are taken as examples for a general method that avoids the difficulties in interpreting medical terms as reported in other studies.
Indoor Positioning Systems Based on Visible Light Communication: State of the Art

Advances in visible light communication (VLC) technology and the ubiquity of illumination facility have led to a growing interest in VLC-based indoor positioning. Numerous techniques have been proposed to obtain better system performance. In this paper, we survey over 100 papers ranging from pioneering papers to the state-of-the-art in the field to present the positioning technology. Not only the light emitting diode technology, modulation method and types of receivers are compared but also a novel taxonomy method is proposed. In this paper, VLC-based indoor positioning systems (VLC-based-IPSs) are classified based on the methods used: 1) mathematical method; 2) sensor-assisted method; and 3) optimization method. Different from other survey works, we emphasize and analyze the accuracy of VLC-based-IPS in the experiment and simulation environments. Meanwhile, this paper illustrates challenges, countermeasures, and lessons learned.
High Factor VIII Activity, High Plasminogen Activator Inhibitor 1 Antigen Levels and Low Factor XII Activity Contribute to a Thrombophilic Tendency in Elderly Venous Thromboembolism Patients

affect the fibrinolytic capacity and increases the risk of thrombotic events in the arterial system. One of the primary regulators of the fibrinolytic system is plasminogen activator inhibitor 1 (PAI 1). Overexpression of PAI 1 may lead to impaired activity of the fibrinolytic system [19] . The aim of our study was to evaluate the age-related differences in activity of clotting factors VIII, XI and XII in patients with a first episode of VTE as well as differences in the fibrinolytic system of these patients reflected by PAI 1 antigen levels. We further evaluated the difference in natural anticoagulants AT, Pro C and Pro S between our older and younger patients. Patients with a history of a single episode of VTE in the past 2 years were enrolled over a period of 6 months at the outpatient clinic of the Division of Angiology, Medical University Graz, Austria. As this was supposed to be a pilot study, no sample size calculation was performed. We excluded patients on full-dose warfarin, patients with active malignancies, patients with acute inflammation, patients with a positive test for antiphospholipid antibodies and patients with signs of an acute deep vein thrombosis, as all these entities influence the activity of clotting Age is an independent risk factor for venous thromboembolic events (VTE) [1] . This seems to be a multifactorial phenomenon. Older patients are at higher risk for VTE due to an increase in disability [2] . Furthermore, the plasma concentration of several clotting factors increases with age in healthy humans as a physiological ageing process [3–7] . These changes in clotting factor activity in the elderly are supposed to be in balance with an increase in natural anticoagulants such as antithrombin (AT), protein C (Pro C) and protein S (Pro S) [8] . Factor VIII, a cofactor in the activation of factor X, is a clotting factor which increases with age, reaching a mean of 1 200 IU/dl in the 7th decade of life [3, 9] . High factor VIII levels are associated with venous as well as with arterial vascular events [10–13] . Changes in the activity of clotting factors XI and XII are also proposed as thrombophilic risk factors [14–16] . However, age-dependent differences in activity of these 2 clotting factors have not yet been described in the literature so far, although they could be of clinical interest. Factor XII activates the fibrinolytic system directly or indirectly and inhibits the thrombin-induced platelet activation [17, 18] . Therefore, low factor XII activity should Received: July 19, 2010 Accepted after revision: September 8, 2010 Published online: November 12, 2010
Does Family Business Group Affiliation In Real Sector Firms Really Affect Their Performance

In this study, we empirically examine the performance effect of group affiliation by comparing the performance of firms that belong to family business groups with the performance of independent firms. For this purpose, we use a sample of 193 Turkish firms (i.e. 90 group affiliated firms and 103 non-group firms) quoted on the Istanbul Stock Exchange (Borsa Istanbul) during the 2005-2012 period. Based on ROA and Tobin’s Q performance measures, the findings obtained from the FEVD estimator reveal that group membership does not always positively affect the financial performance of member firms. There exists a threshold effect of group affiliation, i.e. big group firms are better performers than both small group firms and stand-alone firms. Furthermore, when taken into account of firms’ age, we find that positive effect of group affiliation is only valid for old group affiliated firms.
How long have adult humans been consuming milk?

Lactase is the enzyme that breaks down the milk sugar lactose, and in most mammals, including most humans, lactase activity is down‐regulated after the weaning period is completed. However, in about 35% of adults worldwide, lactase continues to be expressed throughout adulthood, a feature termed lactase persistence (LP). Genetic evidence indicates that LP is a recent human adaptation, and its current geographic distribution correlates with the relative historical importance of dairying in different human populations. Investigating archaeological evidence for fresh milk consumption has proved crucial in building an account of the joint evolution of LP and dairying. A powerful technique for investigating food processing, including milk processing, in ancient populations is lipid residue analysis on archaeological pottery. We review here the archaeological and genetic evidence available that have contributed to a better understanding of the gene‐culture co‐evolution of LP and dairying. © 2013 IUBMB Life, 65(12):983–990, 2013.