Miracle-dz/UniFAR-FTUs huggingface dataset:
Antisecretory and antiulcer activities of a novel proton pump inhibitor AG-1749 in dogs and rats.

The antisecretory and antiulcer activities of 2[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl] sulfinyl]-1H-benzimidazole (AG-1749) were investigated in dogs and rats. AG-1749 inhibited both the (H+ + K+)-adenosine triphosphatase activity in canine gastric microsomes and dibutyryl cyclic AMP-stimulated acid formation in isolated canine parietal cells and suppressed the acid secretion stimulated by histamine, pentagastrin, bethanechol or a peptone meal in Heidenhain pouch dogs; the ID50 values were between 0.2 and 0.7 mg/kg p.o. AG-1749 inhibited both the histamine-stimulated and the basal acid secretion in pylorusligated rats and prevented water immersion stress or aspirin-induced gastric lesions and mepirizole or cysteamine-induced duodenal ulcers in rats; the ID50 values were between 0.3 to 3.6 mg/kg p.o. or i.d. Furthermore, AG-1749 prevented gastric lesions induced by absolute ethanol or acidified aspirin, and accelerated the healing of acetic acid-induced gastric or duodenal ulcers in rats. The inhibitory potency of AG-1749 in dogs was much the same as that of omeprazole and about half that of ranitidine. However, it was about 2 to 10 times more potent than omeprazole and 4 to 34 times more potent than ranitidine in rats. These results suggest that AG-1749 exerts prominent antiulcer activities mainly by suppressing acid secretion via an inhibition of a proton pump in gastric parietal cells and partly by protecting the gastrointestinal mucosa against various ulcerative stimuli.
Theoretical Basis of Some Empirical Relations in Seismology by Hiroo Kanamori And

Empirical relations involving seismic moment M_o, magnitude M_S, energy E_S and fault dimension L (or area S) are discussed on the basis of an extensive set of earthquake data (M_S ≧ 6) and simple crack and dynamic dislocation models. The relation between log S and log M_o is remarkably linear (slope ∼ 2/3) indicating a constant stress drop Δσ; Δσ = 30, 100 and 60 bars are obtained for inter-plate, intra-plate and “average” earthquakes, respectively. Except for very large earthquakes, the relation M_S ∼ (2/3) log M_o ∼ 2 log L is established by the data. This is consistent with the dynamic dislocation model for point dislocation rise times and rupture times of most earthquakes. For very large earthquakes M_S ∼ (1/3) log M_o ∼ log L ∼ (1/3) log E_S. For very small earthquakes M_S ∼ log M_o ∼ 3 log L ∼ log E_S. Scaling rules are assumed and justified. This model predicts log E_S ∼ 1.5 M_S ∼ 3 log L which is consistent with the Gutenberg-Richter relation. Since the static energy is proportional to σL^3, where σ is the average stress, this relation suggests a constant apparent stress ησ where η is the efficiency. The earthquake data suggest ησ ~ 1/2 Δσ. These relations lead to log S ∼ M_S consistent with the empirical relation. This relation together with a simple geometrical argument explains the magnitude-frequency relation log N ∼ − M_S.
Influence of Sex on Age at Onset of Schizophrenia

Abstract: The age at onset of schizophrenia was investigated in 2,417 inpatients (1,433 males and 984 females) meeting the DSM‐III criteria for schizophrenia. About 80% of the patients became schizophrenic before the age of 30. The mean age at onset of the male patients was slightly earlier than that of the female patients. There was a higher cumulative percentage of the male patients who became affected at each age quinquennium. More men than women became schizophrenic before the age of 30.
Cost-Benefit Analysis of a Support Program for Nursing Staff

Supplemental digital content is available in the text. Objectives A peer-support program called Resilience In Stressful Events (RISE) was designed to help hospital staff cope with stressful patient-related events. The aim of this study was to evaluate the impact of the RISE program by conducting an economic evaluation of its cost benefit. Methods A Markov model with a 1-year time horizon was developed to compare the cost benefit with and without the RISE program from a provider (hospital) perspective. Nursing staff who used the RISE program between 2015 and 2016 at a 1000-bed, private hospital in the United States were included in the analysis. The cost of running the RISE program, nurse turnover, and nurse time off were modeled. Data on costs were obtained from literature review and hospital data. Probabilities of quitting or taking time off with or without the RISE program were estimated using survey data. Net monetary benefit (NMB) and budget impact of having the RISE program were computed to determine cost benefit to the hospital. Results Expected model results of the RISE program found a net monetary benefit savings of US $22,576.05 per nurse who initiated a RISE call. These savings were determined to be 99.9% consistent on the basis of a probabilistic sensitivity analysis. The budget impact analysis revealed that a hospital could save US $1.81 million each year because of the RISE program. Conclusions The RISE program resulted in substantial cost savings to the hospital. Hospitals should be encouraged by these findings to implement institution-wide support programs for medical staff, based on a high demand for this type of service and the potential for cost savings.
Evaluation of Antiviral Activities of Curcumin Derivatives against HSV-1 in Vero Cell Line

Antiviral drug resistance is one of the most common problems in medicine, and, therefore, finding new antiviral agents, especially from natural resources, seems to be necessary. This study was designed to assay the antiviral activity of curcumin and its new derivatives like gallium-curcumin and Cu-curcumin on replication of HSV-1 in cell culture. The research was performed as an in vitro study in which the antiviral activity of different concentrations of three substances including curcumin, Gallium-curcumin and Cu-curcumin were tested on HSV-1. The cytotoxicity of the tested compounds was also evaluated on the Vero cell line. The CC50 values for curcumin, gallium-curcumin and Cu-curcumin were 484.2 μg/mL, 255.8 μg/mL and 326.6 μg/mL, respectively, and the respective IC50 values 33.0 μg/mL, 13.9 μg/mL and 23.1 μg/mL. The calculated SI values were 14.6, 18.4 and 14.1, respectively. The results showed that curcumin and its new derivatives have remarkable antiviral effects on HSV-1 in cell culture.
Rockin' robins: Do congresswomen rule the roost in the Twittersphere?

Recent work by Evans, Cordova, and Sipole (2014) reveals that in the two months leading up to the 2012 election, female House candidates used the social media site Twitter more often than male candidates. Not only did female candidates tweet more often, but they also spent more time attacking their opponents and discussing important issues in American politics. In this article, we examine whether the female winners of those races acted differently than the male winners in the 2012 election, and whether they differed in their tweeting‐style during two months in the summer of 2013. Using a hand‐coded content analysis of every tweet from each member in the U.S. House of Representatives in June and July of 2013, we show that women differ from their male colleagues in their frequency and type of tweeting, and note some key differences between the period during the election and the period after. This article suggests that context greatly affects representatives' Twitter‐style.
Cystic fibrosis transmembrane conductance regulator activation by the solvent ethanol: implications for topical drug delivery

Decreased cystic fibrosis transmembrane conductance regulator (CFTR)‐mediated chloride (Cl) secretion across mucosal surfaces contributes to the development of airway disease by depleting airway surface liquid, increasing mucus viscosity and adhesion, and consequently hindering mucociliary clearance. We serendipitously discovered during testing of drugs solubilized in low concentrations ethanol (0.25%, 43 mM) that the control vehicle produced robust activation of CFTR‐mediated Cl− transport. The objective of the current study is to investigate low concentrations of ethanol for effects on Cl− secretion and ciliary beat frequency (CBF).
Effects of intensive glucose control on incidence of cardiovascular events in patients with type 2 diabetes: A meta-analysis

Abstract Background. The effects of intensive glucose control over conventional glucose control on cardiovascular outcomes of patients with type 2 diabetes remain uncertain. Methods. We searched MEDLINE, EMBASE, and the Cochrane database to identify randomized controlled trials that compared the effects of intensive glucose control and conventional glucose control, on cardiovascular events in patients with type 2 diabetes. Results. Seven trials involving 34,144 participants with type 2 diabetes were included. Intensive glucose control significantly reduced major cardiovascular events by 10% (relative risk (RR) 0.90, 95% CI 0.85–0.96; P = 0.0006), and non-fatal myocardial infarction by 16% (0.84, 95% CI 0.76–0.93; P = 0.0006) at the expense of increased incidence of severe hypoglycemia (2.30, 95% CI 1.74–3.03; P < 0.00001), while all-cause mortality, cardiovascular death, non-fatal stroke, and heart failure were similar between the two groups. Subgroup analyses showed that patients with longer follow-up duration, shorter diabetic duration, less glycosylated hemoglobin (HbA1c) reduction, higher HbA1c concentration at follow-up, and lower base-line HbA1c benefited more from intensive glucose control. Conclusion. An intensive glucose control strategy can effectively reduce the risk of major cardiovascular events but at the expense of a significantly increased risk of severe hypoglycemia in patients with type 2 diabetes.
The exocyst subunit Sec3 is regulated by a protein quality control pathway

Exocytosis involves fusion of secretory vesicles with the plasma membrane, thereby delivering membrane proteins to the cell surface and releasing material into the extracellular space. The tethering of the secretory vesicles before membrane fusion is mediated by the exocyst, an essential phylogenetically conserved octameric protein complex. Exocyst biogenesis is regulated by several processes, but the mechanisms by which the exocyst is degraded are unknown. Here, to unravel the components of the exocyst degradation pathway, we screened for extragenic suppressors of a temperature-sensitive fission yeast strain mutated in the exocyst subunit Sec3 (sec3-913). One of the suppressing DNAs encoded a truncated dominant-negative variant of the 26S proteasome subunit, Rpt2, indicating that exocyst degradation is controlled by the ubiquitin-proteasome system. The temperature-dependent growth defect of the sec3-913 strain was gene dosage-dependent and suppressed by blocking the proteasome, Hsp70-type molecular chaperones, the Pib1 E3 ubiquitin-protein ligase, and the deubiquitylating enzyme Ubp3. Moreover, defects in cell septation, exocytosis, and endocytosis in sec3 mutant strains were similarly alleviated by mutation of components in this pathway. We also found that, particularly under stress conditions, wild-type Sec3 degradation is regulated by Pib1 and the 26S proteasome. In conclusion, our results suggest that a cytosolic protein quality control pathway monitors folding and proteasome-dependent turnover of an exocyst subunit and, thereby, controls exocytosis in fission yeast.
Malignant schwannoma of the parapharyngeal space

Abstract We present a case of malignant schwannoma (MS) of the parapharyngeal space which completely encircled the internal carotid artery in close proximity to the skull base and required resection of the internal carotid artery along with the excision of the tumour. There have been three previous case reports in the literature of malignant schwannoma of the parapharyngeal space of which one case was associated with neuroflbromatosis. Our patient did not exhibit any feature of neurofibromatosis.
Growth inhibition of breast cancer cell line MCF-7 by siRNA silencing of Wilms tumor 1 gene.

BACKGROUND RNA interference (RNAi) is sequence-specific inhibition of gene expression induced by double-stranded RNA. OBJECTIVE Define the role of Wilms tumor 1 gene (WT1) in breast cancer oncogenesis using RNAi. MATERIAL AND METHOD MCF-7 breast cancer cells, which express a high level of WT1, were transfected with synthetic small interfering RNA (siRNA) targeting WT1 (siRNA(WT1)) resulting in inhibition of WTI expression, as well as growth, in a dose- and time-dependent manner. RESULT The minimum concentration of siRNA(WT1) for growth inhibition and WT1 silencing was 25 nM and 50 nM respectively. WT1 expression was completely abolished at 200 nM siRNA,. CONCLUSION These data suggest that WTI1is indispensable for the survival of breast cancer MCF-7 cell line.
Activities and some properties of adenylate cyclase and phosphodiesterase in muscle, liver and nervous tissues from vertebrates and invertebrates in relation to the control of the concentration of adenosine 3':5'-cyclic monophosphate.

1. The basal and fluoride-stimulated activities of adenylate cyclase, and the maximal activities of 3':5'-cyclic AMP phosphodiesterase and 3':5'-cyclic GMP phosphodiesterase, together with the Km values for their respective substrates, were measured in muscle, liver and nervous tissues from a large range of animals to provide information on the mechanism of control of cyclic AMP concentrations in these tissues. High activities of adenylate cyclase and cyclic AMP diesterase are found in nervous tissues and in the more aerobic muscles (e.g. insect flight muscles, cardiac muscle and some vertebrate skeletal muscles). The activities of these enzymes in liver are similar to those in the heart of the same animal. The Km values for the enzymes from different tissues and animals are remarkably similar. 2. The comparison of cyclic AMP phosphodiesterase and cyclic GMP phosphodiesterase activities suggests that in vertebrate tissues only one enzyme (the high-Km enzyme), which possesses dual specificity, exists, whereas in invertebrate tissues there are at least two phosphodiesterases with separate specificities. 3. A simple quantitative model to explain the control of the steady-state concentrations of cyclic AMP is proposed. The maximum increase in cyclic AMP concentration predicted by comparison of basal with fluoride-stimulated activities of adenylate cyclase is compared with the maximum increases in concentration produced in the intact tissue by hormonal stimulation: reasonable agreement is obtained. The model is also used to predict the actual concentrations and the rates of turnover of cyclic AMP in different tissues and, where possible, these values are compared with reported values. Reasonable agreement is found between predicted and reported values. The possible physiological significances of different rates of turnover of cyclic AMP and the different ratios of high- and low-Km phosphodiesterases in different tissues are discussed.
Quantitative theory and accurate experiments: low-energy electron scattering by He and H 2 as case studies

Accurate low-energy electron scattering data are needed in many fields of physics. However, accurate experiments are difficult to design and to carry out. By 1967 low-energy electron–He cross sections had been measured by two different techniques, designed to provide accurate data. Unfortunately, the data differed by amounts well outside the estimated error bars. Despite the relative simplicity of the He atom, decisive theoretical calculations on the e–He system could not be done with methods available in 1967. After a decade of development of theoretical methodology it became possible in 1979 to carry out calculations with absolute estimates of residual error limits. The results were found to agree closely with the momentum transfer cross section deduced from electron swarm data and with recent beam data by improved techniques, but were inconsistent with the original beam data of 1965. More recently, a similar conflict exists between data measured for electron-impact vibrational excitation of the hydrogen molecule by electron swarm and beam techniques. This conflict has persisted despite great progress in beam scattering techniques and in theoretical methods. A brief review of the relevant electron scattering theory will be given.
The Influence of Morphology on the Electric Strength of Polymer Insulation

This paper describes the effect of morphological structure on the electric strength and some physico-chemical properties of polymers with flexible chains (HDPE, LDPE, PP) and polymers with rigid chains (CA). It is shown that a polymer body has a discrete structure consisting of elements of different densities. The most regular structure with high density is characteristic of spherulites. Their size may be modified by different methods: heat treatment, plasticization, addition of nucleating agent, modification of molecular weight, etc. The inter-spherulitic boundary regions are shown to determine the electrical properties of the specimen as a whole. As the spherulite size decreases, the density of the polymer within the boundary regions increases, improving the electric strength.
Effectiveness of Pnf Stretching Versus Static Stretching on Pain and Hamstring Flexibility Following Moist Heat in Individuals with Knee Osteoarthritis

Background: Osteoarthritis (OA) is a degenerative joint disease and one of the major public health problem that causesfunctional impairment and reduced quality of life. To compare the effectiveness of PNF Hold relax stretching versus Static stretching on pain and flexibility of hamstring following moist heat in individuals with knee osteoarthritis. Hamstring tightness is the major problem in knee osteoarthritis individuals. Therefore the need of study is comparing the effectiveness of PNF Hold relax stretching versus static stretching on pain and flexibility of hamstrings following moist heat in knee osteoarthritis participants. Determining the effects of PNF Hold relax stretching versus Static stretching along with moist heat on pain and hamstring flexibility by VAS and Active knee extension range of motion in knee osteoarthritis individuals.Methods: 30 subjects with symptoms of knee osteoarthritis were randomly distributed into 2 groups 15 in each group. PNF Hold relax stretching along with moist heat is compared to Static stretching along with moist heat. Pain was measured by Visual Analogue Scale (VAS) and hamstring flexibility by Active knee Extension Range of Motion (AKEROM) by universal goniometer. Measurements are taken pre and post intervention.Results: The results indicated PNF Hold relax stretching along with moist heat showed a statistically significant improvement in pain (p<0.05) and improvement in hamstring flexibility (p<0.05) when compared to Static stretching along with moist heat.Conclusion: Subjects with PNF Hold relax stretching along with moist heat showed significant improvement in pain reduction and improving hamstring flexibility than Static stretching along with moist heat.
An Assessment of Housing Infrastructural Provision in Public Housing: A Case Study of Bashorun Housing Estate Akobo, Ibadan Oyo State, Nigeria.

Infrastructure provision forms important ingredients to housing development and formal housing supply, thus adequate provision of infrastructural facilities are regarded as critical components and facilitator for economic development and key to improving the quality of life in any community irrespective of size. While there is a plurality of housing issues, the problem of infrastructure in housing remains prominent especially when mass housing schemes are considered. The failure of some of these housing schemes has revealed that housing provision transcends the mere provision of shelter for needs of man. Hence, the need to approach the situation in a pragmatic way, with a focus on the infrastructural provision – an important aspect of housing that is often left to fate – in most common housing schemes in developing countries – like Nigeria. For this study, a total of two hundred (200) copies of questionnaire were administered on randomly selected residents within Bashorun housing estate and one hundred and sixty six (166) copies were retrieved. The analysis presented below is therefore based on 166 responses which constitute 83% on the average. This paper therefore reviewed existing literatures and the research method is an empirical survey and case study approach involving quantitative analysis of primary data gathered from the selected housing estate thereby evaluating the state of infrastructures of the selected housing estate, Rank Test on the expected and obtained quality of this facilities shows that (Obtained Quality < Expected Quality). Furthermore, the study confirmed a strong positive relationship existing between infrastructural provision and occupants’ level of satisfaction, while a moderate, positive relationship exist between service rendered by the management authority and occupants’ level of satisfaction, which were attributed to private involvement in housing scheme. The study revealed that for housing development to be sustainable, basic infrastructures had to be put in place. The understanding of these infrastructural provision is thus a necessary prerequisite for developing an effective housing programme. The study underscores the need to consider relevant infrastructures for housing improvement and development in Nigeria with a view to ascertaining the sustainability of the housing environment and from this a conclusion is drawn and recommendations made in generating sustainable solutions to the subject matter. Keywords: Housing, Infrastructural Provision, Infrastructures, Public Housing Estate, Ibadan, Nigeria.
Modern systemic chemotherapy in surgically unresectable neoplasms of appendiceal origin

Appendiceal neoplasms include tumors ranging from benign‐appearing cells with widespread mucin deposits to aggressive poorly differentiated signet ring cell adenocarcinomas. Traditionally, these tumors are treated with cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy. For some patients, cytoreductive surgery is not an option, and minimal published data exist in the management and outcome of these patients. A retrospective analysis was conducted to determine the benefit of modern systemic chemotherapy in patients with disseminated appendiceal neoplasm who were not considered optimal candidates for cytoreductive surgery.
Increased Epstein-Barr virus DNA in oropharyngeal secretions from patients with AIDS, AIDS-related complex, or asymptomatic human immunodeficiency virus infections.

Recent findings strongly implicate human immunodeficiency virus (HIV) as essential to the development of AIDS [1]. The observation that patients with AIDS are usually infected with multiple viruses suggests that possible interactions between HIV and another virus(es) may contribute to the evolution of this disorder [2]. Indeed, an increasing number of reports support a role for EpsteinBarr virus (EBV) in AIDS, including the presence of EBVrelated lymphoproliferative lesions and enhanced serological and virological findings in patients with this disorder [3]. Furthermore, there are several recent accounts of cellular interaction between HIV and EBV [2, 4]. The recent development of EBV-specific cloned DNA probes [5] now allows the rapid quantification of EBV DNA in clinical specimens. The purpose of this study was to expand on the possible contributory role of EBV in the development of AIDS-related complex (ARC) and AIDS by determining the viral load in patients with these disorders. Nucleic acid hybridization was used to quantitate EBV DNA in oropharyngeal specimens from patients with AIDS or ARC or from asymptomatic individuals who were positive for HIV antibody. Results were compared with those from two control groups.