Miracle-dz/UniFAR-FTUs huggingface dataset:
p53, p63 and p73 Network in Breast Cancers

Inactivation of the tumor suppressor p53 is the single most common genetic defect in all human cancers. The p53 tumor suppressor is critically important in regulation of cell cycle progression, senescence, differentiation, DNA repair and apoptosis. The discovery of two closely related homologues, p63 and p73, in 1997 generated instant excitement and quick expectations about their tumor suppressor functions. However, despite a remarkable structural and partial functional similarity among p53, initial p63 and p73 mouse knockout studies revealed an unexpected functional diversity among them. p63 and p73 knockouts exhibit severe developmental abnormalities but no increased cancer susceptibility. While p53 is frequently mutated during tumorigenesis (in over 50% of human tumors), p63 and p73 are rarely mutated. Instead, the p63 locus is amplified in squamous cell carcinomas (Bjorkqvist et al., 1998; Massion et al., 2003) and p73 is overexpressed in many tumor types including breast cancers (Moll and Slade, 2004; Zaika and El-Rifai, 2006; Zaika et al., 1999). Although p63 and p73 can activate apoptosis in vitro, it is clear that they are not classic Knudson-like tumor suppressors like p53. Throughout the years, impressive number of evidences has been uncovered, suggesting that the p53-family play an important role in breast cancers. The emerging picture is that of an interconnected pathway, in which all p53-family proteins are involved in the response to oncogenic stress and physiological inputs. The p53/p63/p73 family members are capable of interacting in many ways that involve direct or indirect protein interactions, regulation of same target gene promoter and regulation of each other’s promoters. As such, fluctuations in the levels of selected p53 family members (or their isoforms) might change the relative availability of shared protein partners, as multiple p53-family proteins compete for interaction. Also, differential expression of selected interactors – linked with genetic variation – may distinguish the response of the p53 pathway to the same potentially oncogenic stimuli in diverse individuals. Despite the recent advances in understanding the unique roles of p53 family protein in breast cancers, there are many outstanding questions. What are the unique functions of the TA and ∆N isoforms of p63 and p73? How is individual p53 family member mediates gene expression regulated by the interaction with mutant p53 and other family member and their splicing variants in the cell? What are the patterns of p53 family isoform expression during normal development and tumorigenesis? What are the upstream signaling pathways that regulate individual p53 family member? What are the p53, p63 and p73 target genes? Do p53, p63 and p73 regulate distinct and/or overlapping sets of genes? Understanding the
Knowing what’s good for you: Can a repayment flexibility option in microfinance contracts improve repayment rates and business outcomes?∗

Flexible microfinance contracts can help borrowers mitigate the negative effects of income fluctuations. But the additional liquidity repayment flexibility entails can increase default. Can this risk be mitigated by using contract price as a screening mechanism? We implement a randomized experiment where, in treated branches, borrowers select between the standard, rigid contract and a more expensive flexible contract. In control branches, customers are only offered the standard contract. Treated clients have similar repayment rates but better business outcomes. Selection is important: in treated branches, time-consistent and financially sophisticated borrowers are significantly more likely to opt for the flexible repayment schedule.
Interorganizational Collaboration and the Locus of Innovation: Networks of Learning in Biotechnology.

This research was supported by grants provided to the first author by the Social and Behavioral Sciences Research Institute, University of Arizona, and the Aspen Institute Nonprofit Sector Research Fund and by grants to the second author by the College of Business and Public Administration, University of Arizona. We have benefited from productive exchanges with numerous audiences to whom portions of this paper have been presented: a session at the 1994 Academy of Management meetings, the Social Organization workshop at the University of Arizona, the Work, Organizations, and Markets workshop at the Harvard Sociology Department, the 1994 SCOR Winter Conference at Stanford University, and colloquia at the business schools at the University of Alberta, UC-Berkeley, Duke, and Emory, and the JFK School at Harvard. For detailed comments on an earlier draft, we are extremely grateful to Victoria Alexander, Ashish Arora, Maryellen Kelley, Peter Marsden, Charles Kadushin, Dick Nelson, Christine Oliver, Lori Rosenkopf, Michael Sobel, Bill Starbuck, Art Stinchcombe, and anonymous reviewers at ASQ. We thank Dina Okamoto for research assistance and Linda Pike for editorial guidance. Address correspondence to Walter W. Powell, Department of Sociology, University of Arizona, Tucson, AZ 85721. We argue in this paper that when the knowledge base of an industry is both complex and expanding and the sources of expertise are widely dispersed, the locus of innovation will be found in networks of learning, rather than in individual firms. The large-scale reliance on interorganizational collaborations in the biotechnology industry reflects a fundamental and pervasive concern with access to knowledge. We develop a network approach to organizational learning and derive firm-level, longitudinal hypotheses that link research and development alliances, experience with managing interfirm relationships, network position, rates of growth, and portfolios of collaborative activities. We test these hypotheses on a sample of dedicated biotechnology firms in the years 1990-1994. Results from pooled, within-firm, time series analyses support a learning view and have broad implications for future theoretical and empirical research on organizational networks and strategic alliances. *
Water Kefir grain as a source of potent dextran producing lactic acid bacteria

Water kefir is abeverage fermented by a microbial consortium captured in kefir grains. The kefir grains matrix is composed of polysaccharide, primarily dextran, whichis produced by members of the microbial consortium. In this study, we have isolated lactic acid bacteria (LAB) from non-commercial water kefir grains (from Belgrade, Serbia) and screened for dextran production. Among twelve Lisolates threeproduced slime colonies on modified MRS (mMRS) agar containing sucrose instead of glucoseand were presumed to produce dextran. Three LABwere identified based on morphological, physiological and biochemical characteristics and 16S rRNA sequencing as Leuconostoc mesenteroides(strains T1 and T3) and Lactobacillus hilgardii (strain T5). The isolated strains were able to synthesize a substantial amount of dextran in mMRS broth containing 5% sucrose. Maximal yields (11.56, 18.00 and 18.46 g/l) were obtained after 16h, 20h and 32h for T1, T3 and T5, respectively. Optimal temperature for dextran production was 23oC for two Leuconostoc mesenteroides strains and 30oC for Lactobacillus hilgardii strain. The produced dextrans were identified based on paper chromatography while the main structure characteristics of purified dextranwere observed by FT-IR spectroscopy. Our study shows that water kefir grains are a natural source of potent dextranproducing LAB. [Projekat Ministarstva nauke Republike Srbije, br. TR 31035]
EXPERIMENTAL CONFIRMATION OF GUIDANCE PROPERTIES USING PLANAR ANISOTROPIC LEFT-HANDED METAMATERIAL SLABS BASED ON S-RING RESONATORS

We experimentally studied the guidance properties of the S-shaped metamaterial slabs. A peek of transmitted power due to the bulk guidance modes is observed in the negative band of the metamaterial,which is larger than a conventional dielectric waveguide made of FR4. The peek transmission frequency is shown related with the change of the negative band of the S-shaped metamaterial slab. Our results show good agreement with the theoretical predictions.
Management of distal tibial metaphyseal fractures by expert tibial nail

Introduction: Distal tibial metaphyseal fractures causes extensive musculoskeletal damage and needs an accurate fixation with minimal soft tissue damage. The optimal method of fixation remains debatable. Open reduction and internal fixation cause devascularizing fracture fragments with soft tissue and skin problems. Intramedullary nailing interlocking tibial nails are reported with high complication rates. Expert Tibia Nail (ETN) provides an alternative to these fractures. We studied the efficacy of the ETN in treating distal tibial metaphyseal fractures. Materials and Method: We did a retrospective analysis of distal tibial metaphysic fractures treated with ETN done between June 2010-May 2012. 72 patients with AO type 4.3. A1, A2, A3 were included in the study. The outcome was assessed based on fracture union, fracture alignment, range of knee and ankle movements, secondary procedure rate and postoperative complications within 1yr. Results: The average time of fracture healing was 16 wks. Delayed union was seen in 11.11%. Reoperation rate including dynamisation was 12.5%. Primary malalignment was reported in 6.9% of the cases and 2.7% had secondary malalignment. Majority of patients had good to excellent knee and ankle range of motion. Four patients had wound dehiscence and 3 had infections. Discussion: The results of our study validate the efficacy of ETN in distal tibial metaphyseal fractures. Fracture union was demonstrated in about 90% of the cases within 6 months of surgery and all patients achieved fracture union within 1 year after surgery. Stability and alignment of fracture were achieved with an additional fixation of fibula without increasing risk of delayed union. Expert tibia nail due to its multiplanar locking options, locking option at the tip of nail, provides angular stability. Conclusion: ETN provides stable internal fixation, early ROM knee and ankle, provides angular stability and hence provides excellent clinical and radiological outcome.
Coastal topography drives genetic structure in marine mussels

Understanding population connectivity is fundamental to ecology, and, for sedentary organisms, connectivity is achieved through larval dispersal. We tested whether coastal topography influences genetic structure in Perna perna mussels by comparing populations inside bays and on the open coast. Higher hydrodynamic stress on the open coast produces higher mortality and thus genetic turnover. Populations on the open coast had fewer private haplotypes and less genetic endemism than those inside bays. Gene flow analysis showed that bays act as source populations, with greater migration rates out of bays than into them. Differences in genetic structure on scales of 10s of kilometres show that coastal configuration strongly affects selection, larval dispersal and hap- lotype diversity.
Management skill , entrepreneurial mindset , and enterprise survival : Evidence from randomized experiments and repeated surveys in Vietnam

We conducted randomized experiments to provide management training for 312 Vietnamese small manufacturers in 2010 and repeatedly collected follow-up data in 2011, 2013, and 2016. Analyzing panel data constructed from our surveys with negligible incidence of attrition (less than 2 percent of the baseline sample), we find that the treated enterprises were 17 percentage points more likely to continue business five years after the training, when a five-year survival rate among the control group was 52 percent. In addition, the treated enterprises, particularly a sub-group that received both classroom and on-site training programs, had significantly higher business performance than the control group. Mediation analysis suggests that the higher business performance was due to sustainably improved management skill and change in entrepreneurial mindset.
Knowledge, attitudes and practices of nurses regarding to post-operative pain management at hospitals of Arsi zone, Southeast Ethiopia, 2018

Background : There is limited evidence on nurses’ knowledge, attitude and practice of post operative pain management in Ethiopia. The present study aimed to assess Knowledge, Attitudes and Practices of Nurses Regarding Post-operative Pain Management at Hospitals of Arsi zone, Southeast Ethiopia. There are still inadequacies of knowledge and attitude regarding post-operative pain management practice in the study area. Methodology: A self reported institutional based quantitative cross-sectional study design was used to collect data from 144 nurses who were providing post operative patient care conducted from 24 th April to 12 th May 2018. Data was collected by using structured self- administered questionnaire, which was adopted from previous studies to collect the data and verified, coded and entered to Epi Info Software version 3.5. 4 and then it exported and analyzed by SPSS version 21 Software for data analysis. Descriptive statistics were used to describe demographic characteristics, level of nurses’ knowledge on pain management, attitude towards pain management and their practice and significance of determinant factors were tested using Logistic regression and Odds Ratio & P< 0.05 at 95% CI. Binary logistic regressions were used to see the association or the relationship between dependent and independent variables. Results: Findings of the present study revealed that the majority of nurses who participated in this study had shown good knowledge about pain management (54.86%) but Nurses were questioned to assess their attitude to score 9 questions on a five point Likert scale related to post-operative pain management. The mean score for attitude was 30.62 with standard deviation of 2.681. Respondents who scored more than the mean value were regarded as having Favorable attitude towards post-operative pain management. Nurses who scored less than the mean value were regarded as having unfavorable attitude towards post-operative pain management reveals that (52.1 %) and practice of nurses in post operative pain management were very low (52.1%). Conclusions: As the nurses are the most important parts in the multidisciplinary approach in pain management, their knowledge and attitude make a big difference. So, there is a need for regular in-service training on pain management according to the recommendation of standard.
AntNest: Fully Non-Interactive Secure Multi-Party Computation

In this paper, we focus on the research of non-interactive secure multi-party computation. At first, we propose a fully homomorphic non-interactive verifiable secret sharing (FHNVSS) scheme. In this scheme, shareholders can generate shares of any-degree polynomials of shared numbers without interaction, and the dealer can verify the correctness of shares sent by shareholders without interaction. We implemented the FHNVSS scheme in Python with a detailed performance evaluation. According to our tests, the performance of FHNVSS is satisfactory. For instance, when the request is a 10-degree polynomial of secret value, generating a response takes about 0.0017263 s; verifying a response takes about 0.1221394 s; recovering a result takes about 0.0003862 s. Besides, we make an extension on the FHNVSS scheme to obtain a fully non-interactive secure multi-party computation, called AntNest. In the AntNest scheme, distrustful parties can jointly calculate a any-degree negotiated function, the inputs of which are inputs of all parties, without interaction, and each party can verify the correctness of responses sent by parties without interaction. To the best of our knowledge, it is the first work to realize that parties can jointly calculate any-degree function, the inputs of which are inputs of all parties, without interaction.
Assessing the Use of YouTube Videos and Interactive Activities as a Critical Thinking Stimulator for Tertiary Students: An Action Research.

The purpose of this action research was to investigate the use of YouTube videos and interactive activities in stimulating critical thinking among students from a public university in Malaysia. There were 50 students of mixed background, comprised of local and foreign students who participated in this study which lasted for one semester. Data was collected using a few approaches which included video recording of the lessons, students’ and researcher’s reflections and role play. In this paper, we specifically focus on the students’ reflections of their experience while using YouTube videos. Thematic analysis was conducted to examine the themes that emerged in their reflections. Using Lewin’s Action research model supported by Constructivism Theory, a-four stage action research consisted of planning, acting, observing and reflecting were conducted. We found that YouTube Videos were fun and interesting, increased students’ participation and engagement and enhanced their critical thinking skills. The students were able to participate actively and demonstrated strong interest in the learning process as they were able to understand lectures better by visualizing the content and relating it to real workplace. Our study revealed the potential of YouTube video as a tool for stimulating students’ learning and enhancing their critical thinking.
Visual Grounding Via Accumulated Attention

Visual grounding (VG) aims to locate the most relevant object or region in an image, based on a natural language query. Generally, it requires the machine to first understand the query, identify the key concepts in the image, and then locate the target object by specifying its bounding box. However, in many real-world visual grounding applications, we have to face with ambiguous queries and images with complicated scene structures. Identifying the target based on highly redundant and correlated information can be very challenging, and often leading to unsatisfactory performance. To tackle this, in this paper, we exploit an attention module for each kind of information to reduce internal redundancies. We then propose an accumulated attention (A-ATT) mechanism to reason among all the attention modules jointly. In this way, the relation among different kinds of information can be explicitly captured. Moreover, to improve the performance and robustness of our VG models, we additionally introduce some noises into the training procedure to bridge the distribution gap between the human-labeled training data and the real-world poor quality data. With this “noised” training strategy, we can further learn a bounding box regressor, which can be used to refine the bounding box of the target object. We evaluate the proposed methods on four popular datasets (namely ReferCOCO, ReferCOCO+, ReferCOCOg, and GuessWhat? ). The experimental results show that our methods significantly outperform all previous works on every dataset in terms of accuracy.
Intonation Unit Size in Spontaneous Hebrew: Gender and Channel Differences

In this corpus-driven research, the question of whether there is a tempo at the Intonation Unit (IU) level, and whether defined IUs differ not only with regard to their pitch contour and boundary tones but also with respect to their phonological size. For this reason, the inventory of syllable size (in terms of segments (phonemes)) and word size (in terms of syllables) was examined, and then each IU category (mainly Terminal vs. Continuous) was measured with respect to the number of syllables and words it contains. Moreover, terminal IU size was also measured with regard to the amount of embedded continuous IUs. Results showed that terminal IUs in spontaneous Israeli Hebrew (IH) do not necessarily consist of embedded continuous IUs. This can be explained due to their massive use as short feedback units in spontaneous speech. Statistical measurements for gender and channel (Face-to-Face vs. telephone conversations) variables were carried with no significance for gender, but with statistically significance for several channel aspects. Last, estimated durational measurements of the IU size are presented.
Measuring Attitude towards Risk Treatment Actions amongst Information Security Professionals : an Experimental Approach

Risk management lies at the core of information security. Professionals need to assess risk and make decisions on how to treat risk. Risk perception and judgement of individuals are inherently involved in this process. This paper examines information security professionals’ attitude to risk. We conduct an online experiment and survey which solicits preferences using risky lotteries. We also test whether framing of decisions as gains, losses, or individually separated losses has an effect on their risk attitude. Framing is found to diversify professionals’ risk behaviour significantly. Our findings suggest that professionals reveal a preference for paying to reduce risk instead of paying to eliminate it. They also prefer to reduce the expected loss of threat scenarios rather than reducing the vulnerability associated with this loss. Overall, professionals are risk averse when they face lotteries with small probabilities of loss and risk seeking for lotteries with large probabilities.
Harsh parenting practices mediate the association between parent affective profiles and child adjustment outcomes: Differential associations for mothers and fathers

Children’s early emotional environment strongly influences their later behavioural development. Yet, besides maternal depression, limited knowledge exists about the effect of other emotions and the role of fathers. Using 290 triads (mother/father/child), we investigated how positive (SEEKING, CARING, PLAYFULNESS) and negative (FEAR, ANGER, SADNESS) dimensions of mothers’ and fathers’ affectivity relate to their offspring’s externalizing and internalizing behaviours directly as well as indirectly via parenting practices. Parental variables were measured when children were 4 years old and children’s behaviours were measured at 8 years of age. Latent Profile Analysis identified three parental affective profiles: low negative emotions, balanced, and high emotional. Structural equation models showed that, for boys, mothers’ low negative emotions and high emotional profiles predicted later internalizing behaviours (direct effect; β = −0.21 and β = 0.23), while fathers’ low negative emotions profile predicted externalizing behaviours indirectly (β = −0.10). For girls, mothers’ profiles (low negative emotions and high emotional) predicted both internalizing (β = −0.04 and β = 0.07) and externalizing (β = −0.05 and β = 0.09) behaviours indirectly, but no effects of fathers’ profiles were found. Mothers’ and fathers’ affective profiles contributed to the behavioural development of their offspring in different ways, according to the type of behaviour (internalizing or externalizing) and the child’s sex. These findings may help in tailoring existing parenting interventions on affective profiles, thus enhancing their efficacy.
Spontaneous spin bifurcations and ferromagnetic phase transitions in a spinor exciton-polariton condensate

We observe a spontaneous parity breaking bifurcation to a ferromagnetic state in a spatially trapped exciton-polariton condensate. At a critical bifurcation density under nonresonant excitation, the whole condensate spontaneously magnetizes and randomly adopts one of two elliptically polarized (up to 95% circularly-polarized) states with opposite handedness of polarization. The magnetized condensate remains stable for many seconds at 5 K, but at higher temperatures it can flip from one magnetic orientation to another. We optically address these states and demonstrate the inversion of the magnetic state by resonantly injecting 100-fold weaker pulses of opposite spin. Theoretically, these phenomena can be well described as spontaneous symmetry breaking of the spin degree of freedom induced by different loss rates of the linear polarizations.