Miracle-dz/UniFAR-FTUs huggingface dataset:
“Coke on Tick”: exploring the cocaine market in the UK through the lens of financial management

Purpose This paper aims to offer detailed preliminary data and analysis that focuses specifically on the structures and financial aspects of the UK cocaine market. Design/methodology/approach This paper is based on in-depth interviews with – among others – four active criminal entrepreneurs involved in powder cocaine supply in the UK. Furthermore, along with a review of relevant literature and open sources, in-depth interviews were undertaken with a range of experts with knowledge of the cocaine market. These experts include law enforcement agents and independent academics/researchers who have researched the cocaine market in the UK and internationally. Findings The cocaine market is a fragmented business dependent on networks of individual entrepreneurs and groups. At the core of collaborations often lie family, ethnic or kinship relationships and relationships forged within legal businesses and in prison. Capital investment practices in this market are flexible, “messy” and mutating, and money comes from a range of different sources. Credit is an integral feature of the cocaine business in the UK. The financial management of the cocaine trade is a result of (and reflects) a number of factors, such as the fragmented and decentralised nature of the trade. Originality/value Empirical research into financial aspects of organised crime manifestations is important for the assumptions that are part of public debate to be tested. In addition, understanding the broader range of financial aspects of organised crime is an important component of the process of crimes for gain and can contribute to both better investigation and better prevention.
Neuropathological features of multiple system atrophy with cognitive impairment

Cognitive impairment (CI) is an exclusion criterion for the diagnosis of multiple system atrophy (MSA), according to the second consensus statement. This view was recently challenged by patients with pathologically confirmed MSA who were reported to have dementia. With an aim to investigate the pathological substrate of CI in MSA, quantitative assessment of the glial and neuronal cytoplasmic inclusions and semiquantitative assessment of neuronal loss in the cortical and limbic regions was performed. No differences in the severity of these MSA‐related pathological findings were identified between nine MSA cases with CI and nine MSA cases with normal cognition. Alzheimer's‐related pathological changes, cerebral amyloid angiopathy, and cerebrovascular disease did not differ between the two MSA groups. MSA‐specific α‐synuclein and secondary pathological conditions were not more severe in MSA cases with CI, suggesting that although CI may be intrinsic to the MSA disease process, further investigation into the pathological basis of cognitive impairment in MSA is warranted. © 2014 International Parkinson and Movement Disorder Society
Falls in the elderly: a prospective study of risk factors and risk profiles.

In this prospective study, the authors determined intrinsic risk factors for falls and recurrent falls and constructed a risk profile that indicated the relative contribution of each risk factor and also estimated the probabilities of falls and recurrent falls. In 1992, over a 28-week period, falls were recorded among 354 elderly subjects aged 70 years or over who were living in homes or apartments for the elderly in Amsterdam and the vicinity. During the study period, 251 falls were reported by 126 subjects (36%), and recurrent falls (> or =2 falls) were reported by 57 subjects (16%). Associations of falls and recurrent falls with potential risk factors were identified in logistic regression models. Mobility impairment regarding one or more of the tested items (i.e., impairment of balance, leg-extension strength, and gait) was associated with falls (adjusted odds ratio (OR) =2.6) and was strongly associated with recurrent falls (OR = 5.0). Dizziness upon standing was associated with falls (OR = 2.1) and recurrent falls (OR = 2.1). However, several risk factors were associated with recurrent falls only: history of stroke (OR = 3.4), poor mental state (OR = 2.4), and postural hypotension (OR = 2.0). The authors constructed a risk profile for recurrent falls that included the five risk factors mentioned above. Inclusion of all risk factors in the profile implied an 84% probability of recurrent falls over a period of 28 weeks, compared with 3% when no risk factor was present. The probability of recurrent falls ranged only from 11% to 29% when predicted by number of falls occurring in the previous year. Physical activity, use of high-risk medication, and the use of vitamin D3, which was randomly allocated to the participants, were not strongly related to either falls or recurrent falls. In conclusion, a large range of probabilities of falls, especially of recurrent falls, was estimated by the risk profiles, in which mobility impairment was the major risk factor. Recurrent fallers may therefore be especially amenable to prevention based on mobility improvement.
Monospecific Equine Antiserum Against Cholera Exo-Enterotoxin

An antiserum specific for Vibrio cholerae exo-enterotoxin was produced by immunization of a horse with purified choleragenoid, a natural cholera toxoid. The serum has a high titer against the toxin antigen in passive hemagglutination tests and a respectable antipermeability factor activity. It also passively protected against choleragen-induced mouse foot edema. The serum was found to be useful for assaying toxin antigen in crude and refined products by in vitro tests such as radial immunodiffusion, Lf, and quantitative precipitin titrations. Based upon experimental observations, the serum was defined as containing 1,000 flocculating units of anticholera toxin antibody per ml. A flocculating dose, or Lf, of choleragen approximates 1 μg, and that of choleragenoid is 0.625 μg. Formalin toxoids behaved like the parent toxin in these tests. The serum contains approximately 2.2 mg of antibody protein per ml, which appears to be largely, if not entirely, of the Ig(T) type. It is suggested that this serum, which is available in considerable supply, be considered for use as a reference cholera antitoxin. The horse developed symptoms of anaphylactic shock during immunization, suggesting the need for caution in projected studies on toxoid-induced immunity in man.
Psychiatric symptoms are not an independent mortality risk factor in community-living elderly people

ABSTRACT Background: Mortality risk factors have attracted great research interest in recent years. Physical illness is strongly associated with mortality risk in elderly people. Furthermore, a relationship between mortality risk and psychiatric disease in the elderly has gained research interest. Methods: This is a prospective longitudinal multicenter study. A sample of 324 participants was selected as a representative sample of community members aged 65 years and older and living in Huesca (Spain). The following information was collected: affiliation data, severity of physical illness, psychosocial, and psychiatric factors. Statistical analyses were completed with a multivariate analysis in order to control possible confounding variables related to mortality. Results: Of the initially selected sample, 293 participants were assessed. Sixty-four participants died (21.8%, 95% CI [16.9%, 26.7%]), 5.3% annual rate, and 46.1% showed symptomatology of mental disorders. Older people have eight times greater risk of mortality. The risk increased 53 times in patients affected by several physical illness. No relationship between cognitive dysfunction and depressive symptomatology was observed. In fact, physical condition was associated with depression, and the percentage of participants with depressive symptoms increased according to the severity of physical illness. Conclusions: Severity of physical illness and age are independently and directly associated with mortality in the elderly people. Therefore, severity of physical illness seems to be a crucial factor in the bi-directional association between mortality and depression, acting as a risk factor independently for both. So the relationship between depression and mortality can be affected by the severity of physical illness.
The Framing and Reframing of Corporate Financial Results: How Corporate Earnings Releases Become News

Purpose – News agencies are important stakeholders for large organizations, since the news they distribute will be adopted by other news outlets, which influence public opinion and hence corporate reputation. The purpose of this paper is to advance the understanding of how corporate earnings press releases are transformed into financial news by investigating whether the frames introduced by companies are adopted or reframed by news agencies. Design/methodology/approach – A content analysis of framing techniques in corporate earnings releases and their corresponding news-agency releases was performed, focussing on the financial figures and benchmarks presented, performance attributions, and the tonality of the texts. Findings – The findings suggest that news agencies reframe earnings releases at the textual-pragmatic level by reducing their length, using fewer financial figures, and changing the position of these figures in the texts; they increase transparency by avoiding adjusted financial figures, quali.
Maxillary expansion therapy in children with Down syndrome.

PURPOSE The purpose of this study was to evaluate orthodontic treatment with maxillary expanders (MEs) in a group of Down syndrome (DS) children while also analyzing the rate of activation of the appliance, the complications during the expansion phase, and the expansion outcomes. METHODS Thirty-two DS children underwent ME treatment. Sixty-four controls matched for age, sex, and type of ME were selected. The variables analyzed were previous dental treatment, orthodontic diagnosis, and ME treatment. RESULTS Slow activation of the ME was used in 28% of the DS patients vs 9% of controls (P > .03). Complications during expansion occurred in 10 DS patients (31%) but in none of the controls (P < .001). The most common complication was the appearance of oral ulcers. At the end of the expansion, the results were considered to be clinically successful in 21 DS patients (66%) and in 50 controls (78%). CONCLUSIONS Maxillary expansion can be undertaken in DS children and is successful in a high proportion of cases if correct case selection has been performed. These patients, however, may require a slow activation of the appliance during the expansion phase and are more susceptible to the appearance of oral ulceration, which can affect the course of treatment.
The menthol and cold sensation receptor TRPM8 in normal human nasal mucosa and rhinitis.

BACKGROUND Menthol and cold sensation trigger symptoms and reflex responses in the upper airway, but the underlying molecular mechanisms are unknown. We have therefore studied nerve fibres expressing the menthol and cold receptor TRPM8 in normal human mucosa, and in rhinitis. TRPM8 nerve fibres were compared with those expressing other TRP receptors including TRPV1 (capsaicin and heat receptor), and TRPA1 (mechano-cold receptor). METHODS Immunohistology and image-analysis were used to study TRP receptors in biopsies of nasal turbinate from control subjects, patients with allergic rhinitis, and non-allergic rhinitis. RESULTS TRPM8-immunoreactive nerve fibres were observed in the sub-epithelium, and were profuse around blood vessels in deeper regions, where they were markedly greater in number than TRPV1+ fibers. Image analysis of TRPM8 in sub-epithelial and vascular regions showed no significant differences between control and the rhinitis patient groups. TRPA1-immunoreactivity was weak and seen rarely in nerve fibres. CONCLUSION We show that TRPM8 nerve fibres are abundant in nasal mucosa particularly around blood vessels, and may mediate neurovascular reflexes. TRPM8 antagonists deserve consideration for therapeutic trial in rhinitis.
DIFFERENTIAL SELECTION TO AVOID HYBRIDIZATION IN TWO TOAD SPECIES

Abstract The fitness consequences of hybridization critically affect the speciation process. When hybridization is costly, selection favors the evolution of prezygotic isolating mechanisms (e.g., mating behaviors) that reduce heterospecific matings and, consequently, enhance reproductive isolation between species (a process termed reinforcement). If, however, selection to avoid hybridization differs between species, reinforcement may be impeded. Here, we examined both the frequency and fitness effects of hybridization between plains spadefoot toads (Spea bombifrons) and New Mexico spadefoot toads (S. multiplicata). Hybridization was most frequent in smaller breeding ponds that tend to be ephemeral, and heterospecific pairs consisted almost entirely of S. bombifrons females and S. multiplicata males. Moreover, in controlled experimental crosses, hybrid offspring from crosses in which S. multiplicata was maternal had significantly lower survival and longer development time than pure S. multiplicata offspring. By contrast, hybrid offspring from crosses in which S. bombifrons was maternal outperformed pure S. bombifrons offspring by reaching metamorphosis faster. These data suggest that, although S. multiplicata females are under selection to avoid hybridization, selection might favor those S. bombifrons females that hybridize with S. multiplicata if their breeding pond is highly ephemeral. Generally, the strength of selection to avoid hybridization may differ for hybridizing species, possibly impeding reinforcement.
Intestinal Microbiota of 6-week-old Infants Across Europe: Geographic Influence Beyond Delivery Mode, Breast-feeding, and Antibiotics

Objectives: There are many differences in diet and lifestyle across Europe that may influence the development of the infant gut microbiota. This work aimed to assess the impact of geographic area, mode of delivery, feeding method, and antibiotic treatment on the fecal microbiota of infants from 5 European countries with different lifestyle characteristics: Sweden, Scotland, Germany, Italy, and Spain. Patients and Methods: Fecal samples from 606 infants (age 6 weeks) recruited within the European project INFABIO were analyzed by fluorescent in situ hybridization combined with flow cytometry using a panel of 10 rRNA targeted group- and species-specific oligonucleotide probes. Information on factors potentially affecting gut microbiota composition was collected with questionnaires and associations were evaluated with multivariate analyses. Results: The Bifidobacterium genus was predominant (40% average proportion of total detectable bacteria), followed by Bacteroides (11.4%) and enterobacteria (7.5%). Northern European countries were associated with higher proportions of bifidobacteria in infant feces, whereas a more diverse microbiota with more bacteroides characterized southern countries. Bifidobacteria dominated the microbiota of breast-fed infants, whereas formula-fed babies had significantly higher proportions of Bacteroides and members of the Clostridium coccoides and Lactobacillus groups. Newborns delivered by cesarean section or from mothers treated with antibiotics perinatally had lower proportions of Bacteroides and members of the Atopobium cluster. Conclusions: Delivery mode and feeding method influenced the fecal microbiota of European infants at 6 weeks, as expected, but the effect of country of birth was more pronounced, with dominant bifidobacteria in northern countries and greater early diversification in southern European countries.
Personality and colorectal cancer: the Fukuoka colorectal cancer study.

OBJECTIVE Although personality factors, especially emotional suppression and loss-hopelessness, have been linked to the occurrence and progression of cancer, little is reported specifically on colorectal cancer. It has also been claimed that a 'hysterical' personality characterized by exaggerated emotional expressions, egocentricity and ambivalent connection may be protective from cancer. This community-based case-control study examined whether personality factors relevant to emotional suppression or loss-hopelessness are associated with an increased risk of colorectal cancer, and whether factors related to the hysterical personality are associated with a decreased risk. METHODS The stress inventory (SI), a self-administered questionnaire to assess the possible disease-prone and other relevant personalities in Japanese, was completed by 497 patients with newly diagnosed colorectal cancer and 809 controls randomly selected in the Fukuoka area of Japan. RESULTS After controlling for age, sex and residence using a logistic regression model, none of the SI scales relevant to emotional suppression ('unfulfilled needs for acceptance', 'altruism', 'rationalizing conflicts/frustrations') or loss-hopelessness ('low sense of control', 'object-dependence/loss', 'object-dependence/happiness') was related to colorectal cancer. On the other hand, two scales representing elements of the hysterical personality, 'object-dependence/ambivalence' and 'egoism' were protectively associated with risk. Additional adjustment for body-mass index and lifestyle factors did not materially change these associations. CONCLUSIONS Although personalities relevant to the emotional suppression or loss-hopelessness may not be a risk factor for colorectal cancer in the Japanese population, ambivalent connection and egocentricity may be protective.
Three enzymatic activities catalyze the oxidation of sulfide to thiosulfate in mammalian and invertebrate mitochondria

Hydrogen sulfide is a potent toxin of aerobic respiration, but also has physiological functions as a signalling molecule and as a substrate for ATP production. A mitochondrial pathway catalyzing sulfide oxidation to thiosulfate in three consecutive reactions has been identified in rat liver as well as in the body‐wall tissue of the lugworm, Arenicola marina. A membrane‐bound sulfide : quinone oxidoreductase converts sulfide to persulfides and transfers the electrons to the ubiquinone pool. Subsequently, a putative sulfur dioxygenase in the mitochondrial matrix oxidizes one persulfide molecule to sulfite, consuming molecular oxygen. The final reaction is catalyzed by a sulfur transferase, which adds a second persulfide from the sulfide : quinone oxidoreductase to sulfite, resulting in the final product thiosulfate. This role in sulfide oxidation is an additional physiological function of the mitochondrial sulfur transferase, rhodanese.
Translation Quality Estimation Using Only Bilingual Corpora

In computer-aided translation scenarios, quality estimation of machine translation hypotheses plays a critical role. Existing methods for word-level translation quality estimation (TQE) rely on the availability of manually annotated TQE training data obtained via direct annotation or postediting. However, due to the cost of human labor, such data are either limited in size or is only available for few tasks in practice. To avoid the reliance on such annotated TQE data, this paper proposes an approach to train word-level TQE models using bilingual corpora, which are typically used in machine translation training and is relatively easier to access. We formalize the training of our proposed method under the framework of maximum marginal likelihood estimation. To avoid degenerated solutions, we propose a novel regularized training objective whose optimization is achieved by an efficient approximation. Extensive experiments on both written and spoken language datasets empirically show that our approach yields comparable performance to the standard training on annotated data.
PHARMACOLOGICAL PROPERTIES OF EXCITATORY NEUROMUSCULAR SYNAPSES IN THE LOCUST

1. The effects of a wide range of amino acids and related compounds on retractor unguis nerve-muscle preparations from the locust, grasshopper and cockroach have been investigated. 2. L-glutamate is the most active excitatory substance. The presence of two acidic groups and one amino group is essential for excitatory activity while the position of the amino group is of some importance in determining the level of activity. 3. When L-glutamate is applied iontophoretically to the muscle fibres, ‘glutamate’ depolarizations are recorded only at the synaptic sites. Other evidence that the action of glutamate is restricted to the synaptic sites is presented. 4. Perfusion of isolated locust retractor unguis nerve-muscle preparations with locust haemolymph does not markedly affect the neurally evoked mechanical responses. It appears that locust haemolymph contains little ‘free’ L-glutamate. 5. Four acidic amino aids have been identified in the perfusate from isolated retractor unguis preparations namely, glycine, alanine, aspartate and L-glutamate. However, only L-glutamate increases in concentration during stimulation of the retractor unguis nerve.
Local Arterial Stiffening Assessed by MRI Precedes Atherosclerotic Plaque Formation

Background—Atherosclerosis is known to impair vascular function and cause vascular stiffening. The aim of this study was to evaluate the potential predictive role of vascular stiffening in the early detection of atherosclerosis. Therefore, we investigated the time course of early functional and morphological alterations of the vessel wall in a murine atherosclerosis model. Because initial lesions are distributed inhomogeneously in early-stage atherosclerosis, MR microscopy was performed to measure vascular elasticity locally, specifically the local pulse wave velocity and the arterial wall thickness. Methods and Results—Local pulse wave velocity and the mean arterial wall thickness were determined in the ascending and the abdominal aortae of ApoE−/− and wild-type mice. In vivo MRI revealed that baseline pulse wave velocity and morphology were similar in 6-week-old ApoE−/− and WT mice, whereas at the age of 18 weeks, local pulse wave velocity was significantly elevated in ApoE−/− mice. Significantly increased vessel wall thickness was not found in ApoE−/− mice until the age of 30 weeks. Histological analysis of the aortae of ApoE−/− and WT mice showed that increased pulse wave velocity coincided with the fragmentation of the elastic laminae in the arterial wall, which is hypothesized to induce early vascular stiffening and may be promoted by macrophage-mediated matrix degradation. Conclusions—We newly report that the assessment of local pulse wave velocity via MRI provides early information about the local progression of atherosclerosis before macroscopic alterations of the vessel wall occur.