Miracle-dz/UniFAR-FTUs huggingface dataset:
Mesenteric ischaemia: A multidisciplinary approach

Mesenteric ischaemia may result from a wide range of pathological processes, each possessing unique clinical features, diagnostic difficulties, management strategies and outcome. Regardless of aetiology, prognosis depends crucially on rapid diagnosis and institution of treatment to prevent, or at least to minimize, bowel infarction. Progress in understanding the pathophysiology of mesenteric ischaemia has led to novel methods of treatment, so that in some circumstances therapy may be purely medical. More often surgery is required and is frequently life saving. Percutaneous transcatheter techniques are increasingly employed in both diagnosis and treatment. Close cooperation between radiologists, physicians and surgeons is therefore necessary if clinical outcome is to be optimized. This paper reviews the modern interdisciplinary management of mesenteric ischaemia in the light recent advances.
Proinflammatory and regulatory cytokines and chemokines in infants with uncomplicated and severe Plasmodium falciparum malaria

Cytokine and chemokine levels were studied in infants (<5 years) with uncomplicated (MM) and severe malaria tropica (SM), and in Plasmodium falciparum infection‐free controls (NEG). Cytokine plasma levels of interleukin (IL)‐10, IL‐13, IL‐31 and IL‐33 were strongly elevated in MM and SM compared to NEG (P < 0·0001). Inversely, plasma concentrations of IL‐27 were highest in NEG infants, lower in MM cases and lowest in those with SM (P < 0·0001, NEG compared to MM and SM). The levels of the chemokines macrophage inflammatory protein (MIP3)‐α/C–C ligand 20 (CCL20), monokine induced by gamma interferon (MIG)/CXCL9 and CXCL16 were enhanced in those with MM and SM (P < 0·0001 compared to NEG), and MIP3‐α/CCL20 and MIG/CXCL9 were correlated positively with parasite density, while that of IL‐27 were correlated negatively. The levels of 6Ckine/CCL21 were similar in NEG, MM and SM. At 48–60 h post‐anti‐malaria treatment, the plasma concentrations of IL‐10, IL‐13, MIG/CXCL9, CXCL16 and MIP3‐α/CCL20 were clearly diminished compared to before treatment, while IL‐17F, IL‐27, IL‐31 and IL‐33 remained unchanged. In summary, elevated levels of proinflammatory and regulatory cytokines and chemokines were generated in infants during and after acute malaria tropica. The proinflammatory type cytokines IL‐31 and IL‐33 were enhanced strongly while regulatory IL‐27 was diminished in those with severe malaria. Similarly, MIP3‐α/CCL20 and CXCL16, which may promote leucocyte migration into brain parenchyma, displayed increased levels, while CCL21, which mediates immune surveillance in central nervous system tissues, remained unchanged. The observed cytokine and chemokine production profiles and their dynamics may prove useful in evaluating either the progression or the regression of malarial disease.
The safety and efficacy of bevacizumab in the treatment of patients with recurrent or metastatic cervical cancer

ABSTRACT Introduction: Bevacizumab is a recombinant humanized monoclonal antibody against vascular endothelial growth factor (VEGF). (Avastin; Genetech, Inc, San Francisco, CA) Angiogenesis is blocked by the binding of bevacizumab to VEGF, inhibiting the binding of this ligand to the VEGF receptor. On 14 August 2014 the Food and Drug Administration (FDA) approved use of bevacizumab in persistent, recurrent, or metastatic cervical cancer. Areas covered: Herein we review pharmacodynamics and kinetics, clinical data and treatment-related toxicities of bevacizumab in the treatment of metastatic, recurrent or persistent cervical cancer. Additionally, future areas of development are reviewed. Expert commentary: Anti-angiogenesis therapy with bevacizumab is central to metastatic, persistent, and recurrent cervical cancer treatment. Additional anti-angiogenesis drugs are in development. Future studies will need to establish if the addition of multiple anti-angiogenesis agents or anti-angiogenesis in combination with immunotherapy is more effective than bevacizumab with chemotherapy.
A 1 MHz Half-Bridge Resonant DC/DC Converter Based on GaN FETs and Planar Magnetics

A 1 MHz half-bridge resonant dc/dc converter based on GaN FETs and planar magnetics is proposed in this paper, which improves the system efficiency and power density. The resonant network can achieve satisfactory soft-switching characteristics based on a small impedance angle, which greatly reduces the losses of switches and diodes. The losses characteristics during the turn-on and turn-off transitions are analyzed in detail. The calculation results show that the GaN FETs with low output capacitance and on resistance can achieve fast switching speed and low losses in high-frequency conditions. To reduce the profile and increase the power density of the system, planar magnetics are used in this paper. The response surface methodology (RSM) and modular layer model (MLM) are adopted to help design the planar inductor and transformer, respectively. Both of the methods offer clearer and more effective ways to design the planar magnetics. A 25-W prototype is built to verify the feasibility of the proposed high-frequency converter.
Preterm twins and triplets. A high-risk group for severe respiratory syncytial virus infection.

OBJECTIVE To assess the impact of multiple births and crowded homes on the severity of respiratory syncytial virus illness in preterm infants with bronchopulmonary dysplasia. RESEARCH DESIGN Retrospective case-control chart review from a prospective longitudinal respiratory illness study. SETTING Neonatal High-Risk Follow-Up Clinic (outpatient setting) and tertiary care hospitals (inpatient setting). PARTICIPANTS Fourteen sets of twins and two sets of triplets followed up between 1983 and 1989 and matched with 34 singleton infants for date of birth (within 3 months) and gestational age (within 1 month). MEASUREMENTS/MAIN RESULTS The risk of developing respiratory syncytial virus illness was significantly higher in multiple-birth infants than in singletons (53% vs 24%; P = .01). Multiple-birth infants were also at greater risk for developing pneumonia (24% vs 6%; P = .05) and requiring hospitalization (32% vs 18%; P = .05) than were singletons. Additional risk factors for developing pneumonia and bronchiolitis were examined in all 68 children. Multiple birth (P = .05), gestational age of less than 30 weeks (P = .02), and crowded homes (defined as more than one person living in 19 m2 of living space [P = .002] or more than one child living in 22 m2 of living space [P = .004]) were additional risk factors for developing pneumonia. CONCLUSION Multiple-birth preterm infants are at a higher risk of developing pneumonia than are singletons. Additional risk factors for developing pneumonia in preterm infants with bronchopulmonary dysplasia include gestational age of less than 30 weeks and crowded homes. At-risk infants with any of these risk factors should be targeted for prophylactic and therapeutic interventions against respiratory syncytial virus.
KEDUDUKAN SAKSI VERBALISAN (SAKSI PENYIDIK) SEBAGAI ALAT BUKTI DI PERSIDANGAN DALAM PEMBUKTIAN PERKARA PIDANA (Studi Kasus di Pengadilan Negeri Boyolali)

sistem peradilan pidana ialah suatu sistem berprosesnya suatu peradilan pidana, dimana masing-masing komponen fungsi yang terdiri dari kepolisian sebagai penyidik, kejaksaan sebagai penuntut umum, pengadilan sebagai pihak yang mengadili dan lembaga pemasyarakatan yang berfungsi untuk memasyarakatkan kembali para terhukum, yang bekerja secara bersama-sama, terpadu dalam usaha untuk mencapai tujuan bersama yaitu untuk menanggulangi kejahatan. Tujuan dari hukum acara pidana adalah untuk mencari dan mendapatkan atau setidak-tidaknya mendekati kebenaran materiil, ialah kebenaran yang selengkap-lengkapnya dari suatu perkara pidana dengan menerapkan ketentuan hukum acara pidana secara jujur dan tepat dengan tujuan untuk mencari siapakah pelaku yang dapat didakwakan melakukan suatu pelanggaran hukum, dan selanjutnya meminta pemeriksaan dan putusan pengadilan guna menemukan apakah terbukti bahwa suatu tindak pidana telah dilakukan dan apakah orang yang didakwa itu dapat dipersalahkan. Saksi verbalisant tidak dikenal dalam Hukum Acara Pidana Umum (KUHAP), namun penggunaan saksi verbalisant ini memang dalam konteks hukum di Indonesia diperbolehkan, asal tetap pada koridor hukum yang ada. Keberadaan saksi verbalisant dalam proses pemeriksaan di pengadilan tidak mutlak harus ada, tergantung bagaimana proses pemeriksaan di pengadilan itu berjalan. Secara bahasa verbalisan dapat diartikan petugas kepolisian yang melakukan tugas penyidikan suatu perkara. Jadi dapat didefinisikan saksi verbalisan adalah penyidik yang memeriksa perkara (pada proses penyidikan) yang dipanggil pada pemeriksaan pengadilan untuk didengar keterangannya terkait dengan perkara yang sedang diperiksa.
SIMULATION OF COMPONENTS OF MICROWAVE HEATING APPLICATORS BY FEMLAB, MICROWAVELAB, AND QUICKWAVE-3D

FEMLAB and MicroWaveLab, two finite element solvers, are evaluated in the context of needs of microwave power engineering. Limitations of the codes are identified by simulation of characteristics of applicators based on circular and rectangular waveguides as well as coaxial-to-ridged- and coaxial-to-double-ridged waveguide transitions. Results are verified by QuickWave-3D.
Prostaglandin E2 concentrations in gingival crevicular fluid: observations in untreated chronic periodontitis.

OBJECTIVES We set out to monitor gingival crevicular fluid prostaglandin E2 (GCF-PGE2) concentrations longitudinally in a cohort of subjects with chronic periodontitis, given that we had noted an unexplained trend for GCF-PGE2 concentrations to gradually increase in control groups and placebo populations in previously published clinical trials. MATERIAL AND METHODS 41 adults with moderate-severe chronic periodontitis were recruited. GCF samples were collected from 8 test sites (with 5-8 mm probing depths and attachment loss) every 30 days for 150 days, and assayed for PGE2. Clinical measurements (probing depths, attachment levels, bleeding on probing) were recorded at days 0 and 150. RESULTS A gradual and statistically significant increase in GCF-PGE2 concentrations was observed over the course of the study, from 40.3 ng/ml to 83.1 ng/ml (p<0.001). When data were expressed as absolute PGE2 content, a similar statistically significant increase from baseline to day 150 was observed (p<0.001). GCF volumes did not vary significantly during the study (p>0.05). Over the same time period, no statistically significant changes in clinical parameters were recorded, with the exception of mean probing depths, which decreased slightly from 5.73 mm to 5.51 mm (p<0.05). CONCLUSION A trend for gradually increasing GCF-PGE2 concentrations in the absence of any clinical signs of disease progression was noted in a group of patients monitored longitudinally. We suggest that this phenomenon is to be expected in longitudinal clinical trials, and propose a new model for the role of PGE2 in the pathogenesis of periodontal destruction. We feel that if GCF mediators are to be monitored in clinical studies, then both concentrations and absolute mediator content should be calculated, and a standardised sampling protocol should be employed.
United with the United States

Huemer, Sini Training reading skills: Towards fluency Jyväskylä, University of Jyväskylä, 2009, 85 p. (Jyväksylä Studies in Education, Psychology and Social Research, ISSN 0075-4625; 360) ISBN 978-951-39-3586-3 (PDF), 978-951-39-3562-7 (nid.) Yhteenveto: Lukemistaitojen harjoittaminen: tavoitteena sujuvuus Diss. This thesis evaluated the effects of training on the improvement of the reading skills, particularly on reading speed or fluency, of poor readers. In languages with a consistent orthography (like Finnish or German), children with reading deficits have considerable problems in reading speed. The aims of the present thesis were two-fold: first, they were related to the effectiveness of different types of training methods, and second, to the selection of the target units for training. In Study 1 the effects of computerized training (with the specific aim of improving graphemephoneme conversion) were investigated among Finnish-speaking children with poor pre-reading skills in Grade 1. The results showed that compared to the children in the control group, who received regular reading support, the children in the computer group improved their letter knowledge. However, in both groups the growth in the accurate reading skills was similar, and relatively rapid. The three further studies focused specifically on the improvement of reading speed among Germanand Finnish-speaking children. In general, the short-term training methods utilising repeated readings led to larger improvements than regular school instruction. When general assisted reading practice was compared with computer-assisted repeated reading, the former showed larger improvements. General reading practice was associated with growth in global reading fluency; however, in the task which aimed at assessing the benefits of the computer program, both methods yielded improvements. These results raise methodological considerations, as the task which measured the effects of computer-trained skills, tapped into distal, rather than proximal, effects. In terms of the selection of the target units, training at the sublexical level had positive effects: first, the reading speed of sublexical multiletter units (such as consonant clusters or syllables) could be enhanced by repeated reading, and second, sublexical training was associated with improvements in the reading of words and pseudowords with the trained segments. Thus, training of sublexical multiletter units offers a way of achieving generalization effects. The finding highlights the need to reconsider the Englishbased theoretical notions of reading skills development in the context of a language with a consistent orthography.
Differences in Physical Fitness between Recreational CrossFit ® and Resistance Trained Individuals

Sousa AFM, Santos BS, Reis T, Valerino AJR, Del Rosso S, Boullosa DA. Differences in Physical Fitness between Recreational CrossFit® and Resistance Trained Individuals. JEPonline 2016;19 (5):112-122. The aim of this study was to compare physical capacities between recreational Crossfit® and resistance trained practitioners. Twenty-six young men participated in this study. They were divided into recreational Crossfit® practitioners of resistance training (CF, N = 13) and resistance trained (RT, N = 13) practitioners. Body mass, height, and percent of body fat were recorded. After familiarization with procedures, components of physical fitness were randomly evaluated on separate days with the following exercises: (a) fixed bar pull-ups for relative strength of upper limbs; (b) shuttle run test over 20 m for endurance assessment; and (c) countermovement jump (CMJ) of lower limbs explosiveness. There were no differences between groups for body composition and performance in pull-ups and CMJ. However, effect size (ES) analyses revealed a greater CMJ performance in CF practitioners (P=0.86, ES=0.73) while the RT subjects exhibited a greater relative strength of the upper limbs (P=0.31, ES=0.67). Meanwhile, the CF group exhibited a better performance in the shuttle run test (P=0.008, ES=1.16). It could be concluded that the CF practitioners exhibit a greater endurance and jump capacities, while the RT practitioners exhibited a greater relative strength in the upper limbs. Further longitudinal studies are warranted for a better understanding of physical training adaptations following these fitness modalities.
Les erreurs médicales

La medecine de proximite n’est pas exempte de risque d’erreur, dans le diagnostic ou la prescription des medicaments. Il n’y a qu’avantage a ce que la prise de conscience de ce risque ait impose au medecin de disposer des connaissances les plus actuelles de la science (evidence-based medicine). Une authentique formation continue des medecins devrait etre le lieu privilegie d’echange des experiences. En se gardant bien de confondre erreur et faute, l’erreur, si anodine qu’elle puisse paraitre, relevee et discutee y a toujours une valeur preventive. C’est en pratique hospitaliere que le risque d’erreur est le plus pregnant du fait de la complexification de la pratique medicale et de l’intervention de nombreux intervenants. Mais il s’etend aussi a l’ensemble du systeme de soins. La survenue d’evenements deleteres y est le plus souvent due a un dysfonctionnement global de la chaine de soins, en un mot a une « erreur systemique ». Sa comprehension devrait etre un objectif essentiel dans une optique de prevention, car une erreur qui n’est pas comprise est une erreur qui se reproduira.
The sports performance application of vibration exercise for warm-up, flexibility and sprint speed

Abstract Since the turn of the 21st century, there has been a resurgence of vibration technology to enhance sport science especially for power and force development. However, vibration exercise has been trialled in other areas that are central to athlete performance such as warm-up, flexibility and sprint speed. Therefore, the aim of this review was to attempt to gain a better understanding of how acute and short-term vibration exercise may impact on warm-up, flexibility and sprint speed. The importance of warming up for sporting performance has been well documented and vibration exercise has the capability to be included or used as a standalone warm-up modality to increase intramuscular temperature at a faster rate compared to other conventional warm-up modalities. However, vibration exercise does not provide any additional neurogenic benefits compared to conventional dynamic and passive warm-up interventions. Vibration exercise appears to be a safe modality that does not produce any adverse affects causing injury or harm and could be used during interval and substitution breaks, as it would incur a low metabolic cost and be time-efficient compared to conventional warm-up modalities. Acute or short-term vibration exercise can enhance flexibility and range of motion without having a detrimental effect on muscle power, however it is less clear which mechanisms may be responsible for this enhancement. It appears that vibration exercise is not capable of improving sprint speed performance; this could be due to the complex and dynamic nature of sprinting where the purported increase in muscle power from vibration exercise is probably lost on repeated actions of high force generation. Vibration exercise is a safe modality that produces no adverse side effects for injury or harm. It has the time-efficient capability of providing coaches, trainers, and exercise specialists with an alternative modality that can be implemented for warm-up and flexibility either in isolation or in conjunction with other conventional training methods.
Theory and Limitations of Genetic Network Inference from Microarray Data

Abstract: Since the advent of gene expression microarray technology more than 10 years ago, many computational approaches have been developed aimed at using statistical associations between mRNA abundance profiles to predict transcriptional regulatory interactions. The ultimate goal is to develop causal network models describing the transcriptional influences that genes exert on each other (via their protein products), which can be used to predict network disruptions (e.g., mutations) leading to a disease phenotype, as well as the appropriate therapeutic intervention. However, microarray data measure only a small component of the interacting variables in a genetic regulatory network, as cells are known to regulate gene expression via many diverse mechanisms. Although many researchers have acknowledged the questionable interpretation of statistical dependencies between mRNA profiles, very little work has been done on theoretically characterizing the nature of inferred dependencies using models that account for unobserved interacting variables. In this work, we review the theory behind reverse engineering algorithms derived from three separate disciplines—system control theory, graphical models, and information theory—and highlight several mathematical relationships between the various methods. We then apply recent theoretical work on constructing graphical models with latent variables to the context of reverse engineering genetic networks. We demonstrate that even the addition of simple latent variables induces statistical dependencies between non–directly interacting (e.g., co‐regulated) genes that cannot be eliminated by conditioning on any observed variables.
Spirituality at work: an employee stress intervention for academics?

This study uses a spiritual appraisal model of stress and health to investigate the moderating effects of spirituality at work on job stress, wellbeing, and ill-being amongst Australian academics (Gall, Charbonneau, Clarke, Grant, Joseph & Shouldice 2005). Academic staff members employed in Australian universities completed a self-report questionnaire containing quantitative measures of spirituality at work (individual, work-unit and organisationwide spirituality), wellbeing, ill-being, job threat stress and job pressure stress (N = 139). Bivariate correlation analyses demonstrated that spirituality at work, wellbeing, ill-being and the job stress variables correlated moderately with each other. However, at the multivariate level, spirituality at work did not moderate the influence of job stress on either wellbeing or ill-being. Instead, job threat stress significantly predicted decreased wellbeing and increased ill-being. It was concluded that further exploration of spirituality at work is required to better understand potential benefits for organisations.
Structured Probabilistic Pruning for Convolutional Neural Network Acceleration

Although deep Convolutional Neural Network (CNN) has shown better performance in various computer vision tasks, its application is restricted by a significant increase in storage and computation. Among CNN simplification techniques, parameter pruning is a promising approach which aims at reducing the number of weights of various layers without intensively reducing the original accuracy. In this paper, we propose a novel progressive parameter pruning method, named Structured Probabilistic Pruning (SPP), which effectively prunes weights of convolutional layers in a probabilistic manner. Specifically, unlike existing deterministic pruning approaches, where unimportant weights are permanently eliminated, SPP introduces a pruning probability for each weight, and pruning is guided by sampling from the pruning probabilities. A mechanism is designed to increase and decrease pruning probabilities based on importance criteria for the training process. Experiments show that, with 4x speedup, SPP can accelerate AlexNet with only 0.3% loss of top-5 accuracy and VGG-16 with 0.8% loss of top-5 accuracy in ImageNet classification. Moreover, SPP can be directly applied to accelerate multi-branch CNN networks, such as ResNet, without specific adaptations. Our 2x speedup ResNet-50 only suffers 0.8% loss of top-5 accuracy on ImageNet. We further prove the effectiveness of our method on transfer learning task on Flower-102 dataset with AlexNet.