Miracle-dz/UniFAR-FTUs huggingface dataset:
Partial discharge diagnosis method using electromagnetic wave mode transformation in actual GIS structure

The diagnosis algorithm using ultra high frequency (UHF) method with the higher-order electromagnetic wave (EM-wave) was examined as the advanced partial discharge (PD) diagnosis method in a gas insulated switchgear (GIS) in the former paper. Previous studies evaluated the characteristics of EM-waves propagated in a simple coaxial cylindrical pipe, or through an L-shaped or a T-shaped pipe formed by combining these. In the present study, components (a hand hole, a post-type spacer, etc.) present in an actual GIS structure were identified, and an evaluation done mainly through an analysis on what effects their presence has on the mode transformation of EM-waves propagated inside a GIS tank. The direction in which a GIS tank is bent is horizontal (0deg) in the L-shape structure. If there is either a post-type spacer or a shield ring inside, and the signal source is in the 0deg direction, the distribution of the EM-wave strength varied according to through the L-shape structure. Also in the case of a T-shaped structure, the distribution of the output after signals are transmitted through the T-shaped junction varied depending on each component. Based on these characteristics, the diagnosis algorithm for PD with higher-order mode EM-waves was improved taking into account the effects of various components existing in an actual GIS, and a PD diagnosis method more suitable for an actual structure was established.
X chromosome inactivation: a hypothesis.

X-chromosome inactivation refers to the coordinate regulation of almost all genes on the mammalian × chromosome. Most models for × chromosome inactivation suppose a role for methylation of × chromosome DNA sequences and/or the heterochromatinization of large «domains» of the × chromosome containing many genes.1 Some recent work concerning the expression of X-linked transgenes, and parallels between regulated expression of sex-linked genes in invertebrates and mammals, suggest that × chromosome inactivation may be a gene-by-gene event mediated by the interaction between regulatory sequences common to all X-linked genes and soluble activators and repressors.
Wave and turbulence measurements at a tidal energy site

This work presents the analysis of wave and turbulence measurements collected at a tidal energy site. A new method is introduced to produce more consistent and rigorous estimations of the velocity fluctuations power spectral densities. An analytical function is further proposed to fit the observed spectra and could be input to the numerical models predicting power production and structural loading on tidal turbines. Another new approach is developed to correct for the effect of the Doppler noise on the high frequencies power spectral densities. The analysis of velocity time series combining wave and turbulent contributions demonstrates that the turbulent motions are coherent throughout the water column, rendering the wave coherence-based methods not applicable to our dataset. To avoid this problem, an alternative approach relying on the pressure data collected by the ADCP is introduced and shows appreciable improvement in the wave-turbulence separation.
A novel N-chlorotaurine–corticosteroid combination as a preservative-free local disinfectant: Influence on the ciliary beat frequency in vitro

Conclusions. The combination of N-chlorotaurine (NCT) and a corticosteroid seems to be a very promising substance for the local therapy of ENT infections. As it can be used without any preservatives, the effect on the ciliary beat frequency (CBF) is much less than that of products containing benzalkonium chloride (BAC). The in vitro results obtained in this study encourage us to perform clinical trials on this novel combination for intranasal application. Objective. To investigate the influence of a novel mixture of NCT and a corticosteroid [fluticasone propionate (FP)] on the CBF of human ciliated cells in vitro.Material and methods. The study was designed as an in vitro study. CBF was measured by means of a photometric technique involving the combination of a light microscope, a photometer, a photographic multiplier and a computerized analyzing unit. Results. The combination of 1% NCT + 0.5 mg/ml FP decreased the CBF to 42.17% of its original value after 20 min. Treatment with BAC lowered the CBF depending on the concentration to 96.61% of its original value with 0.04 mg/ml, to 91.90% with 0.1 mg/ml, to 63.46% with 0.2 mg/ml and to 0% with 0.5 mg/ml. After rinsing in saline, the CBF of samples treated with 1% NCT + 0.5 mg/ml FP recovered to 68.93% of its original value.
Propranolol for infantile haemangiomas: initiating treatment on an outpatient basis

Abstract Introduction Propranolol was recently discovered to be an effective treatment for infantile haemangiomas, and varying doses and monitoring regimens have been proposed. Adverse events, although uncommon, have been reported. Materials and methods This was a retrospective chart review of infants with haemangiomas who were started on propranolol at a dose of 3 milligrams per kilogram per day on an outpatient basis. After a baseline cardiac evaluation including an electrocardiogram and an echocardiogram, treatment was initiated during 6 hours of observation. Results A total of 15 patients were identified; however, only 13 returned for at least one follow-up visit. This cohort was followed up for a median of 2.8 months with a range from 0.2 to 10.0. No hypotension, hypoglycaemia, bronchospasm, or clinically significant bradycardia occurred during treatment. All patients had clinical improvement of their haemangiomas. Conclusions This study suggests that initiating treatment during outpatient observation may be a reasonable alternative to inpatient admission. In addition, expensive testing may not be necessary during pre-treatment screening when the physical examination is normal.
Understanding the roles of registered general nurses and care assistants in UK nursing homes.

BACKGROUND The recent government decision to fund the costs of Registered nursing time in long-term care facilities in England through the Registered Nurse Contribution to Care renders the need to distinguish the role of Registered General Nurses (RGNs) from that of Care Assistants (CAs) in nursing homes increasingly important. AIM The objective of this qualitative study was to obtain an in-depth understanding of the main differences between the roles and functions of RGNs and CAs working in nursing homes in the United Kingdom (UK). DESIGN Data were collected through interviews with nine RGNs and 12 CAs employed in four different nursing homes across England. FINDINGS Our findings suggest that RGNs have difficulty defining and limiting their roles because they have all-embracing roles, doing everything and anything within the home. By contrast, CAs define their role in terms of what they are not allowed to do. This difficulty in limiting their role, in addition to their sense of professional accountability for residents' care, leads RGNs to experience difficulty in delegating tasks to CAs. Both RGNs and CAs agreed that an increase in the number of assistive staff is needed to provide residents with good quality care and suggested that a measure of resident dependency would be a good method by which to determine staffing levels. CONCLUSIONS We recommend that job descriptions that clearly define the roles and responsibilities of both RGNs and CAs are developed so that caregivers at all levels understand each others' roles and work together to co-ordinate, plan and provide residents' care.
Increased phosphate transport of Arabidopsis thaliana Pht1;1 by site-directed mutagenesis of tyrosine 312 may be attributed to the disruption of homomeric interactions.

Members of the Pht1 family of plant phosphate (Pi) transporters play vital roles in Pi acquisition from soil and in planta Pi translocation to maintain optimal growth and development. The study of the specificities and biochemical properties of Pht1 transporters will contribute to improving the current understanding of plant phosphorus homeostasis and use-efficiency. In this study, we show through split in vivo interaction methods and in vitro analysis of microsomal root tissues that Arabidopsis thaliana Pht1;1 and Pht1;4 form homomeric and heteromeric complexes. Transient and heterologous expression of the Pht1;1 variants, Pht1;1(Y312D), Pht1;1(Y312A) and Pht1;1(Y312F), was used to analyse the role of a putative Pi binding residue (Tyr 312) in Pht1;1 transporter oligomerization and function. The homomeric interaction among Pht1;1 proteins was disrupted by mutation of Tyr 312 to Asp, but not to Ala or Phe. In addition, the Pht1;1(Y312D) variant conferred enhanced Pi transport when expressed in yeast cells. In contrast, mutation of Tyr 312 to Ala or Phe did not affect Pht1;1 transport kinetics. Our study demonstrates that modifications to the Pht1;1 higher-order structure affects Pi transport, suggesting that oligomerization may serve as a regulatory mechanism for modulating Pi uptake.
Induction of Simian AIDS in Infant Rhesus Macaques Infected with CCR5- or CXCR4-Utilizing Simian-Human Immunodeficiency Viruses Is Associated with Distinct Lesions of the Thymus

ABSTRACT Newborn rhesus macaques were infected with two chimeric simian-human immunodeficiency virus (SHIV) strains which contain unique human immunodeficiency virus type 1 (HIV-1) env genes and exhibit distinct phenotypes. Infection with either the CCR5-specific SHIVSF162P3 or the CXCR4-utilizing SHIVSF33A resulted in clinical manifestations consistent with simian AIDS. Most prominent in this study was the detection of severe thymic involution in all SHIVSF33A-infected infants, which is very similar to HIV-1-induced thymic dysfunction in children who exhibit a rapid pattern of disease progression. In contrast, SHIVSF162P3 induced only a minor disruption in thymic morphology. Consistent with the distribution of the coreceptors CXCR4 and CCR5 within the thymus, the expression of SHIVSF162P3 was restricted to the thymic medulla, whereas SHIVSF33A was preferentially detected in the cortex. This dichotomy of tissue tropism is similar to the differential tropism of HIV-1 isolates observed in the reconstituted human thymus in SCID-hu mice. Accordingly, our results show that the SHIV-monkey model can be used for the molecular dissection of cell and tissue tropisms controlled by the HIV-1 env gene and for the analysis of mechanisms of viral immunopathogenesis in AIDS. Furthermore, these findings could help explain the rapid progression of disease observed in some HIV-1-infected children.
Eigenanatomy on Fractional Anisotropy Imaging Provides White Matter Anatomical Features Discriminating Between Alzheimer's Disease and Late Onset Bipolar Disorder.

BACKGROUND Late Onset Bipolar Disorder (LOBD) is the arousal of Bipolar Disorder (BD) at old age (>60) without any previous history of disorders. LOBD is often difficult to distinguish from degenerative dementias, such as Alzheimer Disease (AD), due to comorbidities and common cognitive symptoms. Moreover, LOBD prevalence is increasing due to population aging. Biomarkers extracted from blood plasma are not discriminant because both pathologies share pathophysiological features related to neuroinflammation, therefore we look for anatomical features highly correlated with blood biomarkers that allow accurate diagnosis prediction. This may shed some light on the basic biological mechanisms leading to one or another disease. Moreover, accurate diagnosis is needed to select the best personalized treatment. OBJECTIVE We look for white matter features which are correlated with blood plasma biomarkers (inflammatory and neurotrophic) discriminating LOBD from AD. MATERIALS A sample of healthy controls (HC) (n=19), AD patients (n=35), and BD patients (n=24) has been recruited at the Alava University Hospital. Plasma biomarkers have been obtained at recruitment time. Diffusion weighted (DWI) magnetic resonance imaging (MRI) are obtained for each subject. METHODS DWI is preprocessed to obtain diffusion tensor imaging (DTI) data, which is reduced to fractional anisotropy (FA) data. In the selection phase, eigenanatomy finds FA eigenvolumes maximally correlated with plasma biomarkers by partial sparse canonical correlation analysis (PSCCAN). In the analysis phase, we take the eigenvolume projection coefficients as the classification features, carrying out cross-validation of support vector machine (SVM) to obtain discrimination power of each biomarker effects. The John Hopkins Universtiy white matter atlas is used to provide anatomical localizations of the detected feature clusters. RESULTS Classification results show that one specific biomarker of oxidative stress (malondialdehyde MDA) gives the best classification performance ( accuracy 85%, F-score 86%, sensitivity, and specificity 87%, ) in the discrimination of AD and LOBD. Discriminating features appear to be localized in the posterior limb of the internal capsule and superior corona radiata. CONCLUSION It is feasible to support contrast diagnosis among LOBD and AD by means of predictive classifiers based on eigenanatomy features computed from FA imaging correlated to plasma biomarkers. In addition, white matter eigenanatomy localizations offer some new avenues to assess the differential pathophysiology of LOBD and AD.
Review of use of a new rapid real-time PCR, the Cepheid GeneXpert® (Xpert) CT/NG assay, for Chlamydia trachomatis and Neisseria gonorrhoeae: results for patients while in a clinical setting

Rapid diagnostics for Chlamydia trachomatis and Neisseria gonorrhoeae are desirable so that patients can be treated while they are still in the clinic or doctor’s office. The Cepheid GeneXpert® (Xpert) CT/NG assay was US FDA-cleared in December 2012. The assay is a rapid real-time PCR nucleic acid amplified test. The cartridge-based assay detects DNA of Chlamydia trachomatis and Neisseria gonorrhoeae. It is FDA-cleared for use in female endocervical swabs, patient-collected vaginal swabs and for female and male urine specimens from symptomatic and asymptomatic patients. It has demonstrated near-perfect sensitivity and specificity in urogenital specimens. The Xpert is a modular platform for testing samples directly from patients, which requires no hands-on manipulation from specimen loading until results are available. Results are provided in approximately 90 minutes. It has been graded by the FDA as moderately complex for Clinical Laboratory Improvement Amendments. Several publications have reported its promising use in clinical settings.
Extraosseous osteosarcoma: response to treatment and long-term outcome.

PURPOSE To evaluate the clinicopathologic features of extraosseous osteosarcoma (EOO), a rare soft tissue form of osteosarcoma, and to examine its response to multimodality therapy. PATIENTS AND METHODS The medical records of all patients with EOO evaluated at The University of Texas M.D. Anderson Cancer Center between 1960 and 1999 were reviewed for clinicopathologic factors, treatment, and outcome. RESULTS Sixty consecutive patients with EOO were identified, including 38 patients with localized (American Joint Committee on Cancer stages I to III) disease. The majority of patients presented with T2 tumors (n = 35, 58%), and 90% of tumors were located beneath the investing fascia. Twenty-seven patients with measurable and assessable disease were treated with doxorubicin-based chemotherapy (median doxorubicin starting dose, 75 mg/m(2); median number of cycles, four). The overall response rate was 19%, with two complete and three partial responses; one (6%) of 18 doxorubicin-treated patients who underwent subsequent surgery had a pathologic complete response. For the subset of 30 patients with localized disease treated at M.D. Anderson, the 5-year actuarial local recurrence-free, distant recurrence-free, event-free, and disease-specific survival rates were 82% (95% confidence interval [CI], 70% to 98%), 64% (95% CI, 43% to 93%), 47% (95% CI, 30% to 70%), and 46% (95% CI, 26% to 80%), respectively. CONCLUSION EOO should be considered clinically and therapeutically distinct from osseous osteosarcoma. Radiographic response rates and pathologic complete response rates to doxorubicin-based systemic therapy are low.
Fluxless optical fiber attachment for hermetic MOEMS applications

Fluxless soldering is desirable for the hermetic packaging of micro-optoelectromechanical (MOEMS) systems, especially those used in harsh environments, or those that require very long shelf-life. An example of such a microsystem is a safe & arm (S&A) MEMS device that requires reliable operation over 20 to 30 years. For this application, degradation and out-gassing of the organic materials, such as those contained in fluxes and epoxies could result in the contamination and stiction of the moving microparts. In this paper we present simulation and experimental results of using a diode laser to attach and seal fiber optic feed-throughs to a kovar carrier package. In order to obtain reliable fluxless solder joints, certain environmental conditions namely, an inert and/or reducing gas environment needs to be present during the process. In addition, the solder and substrate surfaces must be sufficiently free of oxides and organic contaminants. Acceptable process parameters such as the laser power density, spot size, and duration, package geometry have been determined both experimentally and through simulation. It has been established that oxygen levels less than 0.04% (400 ppm) obtained inside a glove-box obtained using inert gas (100% N2 or 95%N2, 5% H2) is necessary to achieve adequate joints
Peripheral Circulation of Veterans and Non-Veterans with Peripheral Artery Disease and Claudication

We compared the peripheral vascular function of veterans and non-veterans with peripheral artery disease (PAD) and claudication. The circulation of the lower extremities was assessed under rest and reactive hyperemia conditions in 413 veterans and in 83 non-veterans. Veterans had more severe PAD as measured by a lower ankle/brachial index (p < 0.001). Following the occlusive test, veterans had a greater relative percentage decrease in ankle systolic blood pressure (p = 0.015), a greater percentage decrease in calf transcutaneous oxygen tension (p = 0.035), and a blunted percentage increase in calf blood flow (p = 0.031). We conclude that veterans with PAD and claudication have greater impairments in macrovascular and microvascular function of the lower extremities, and greater severity of PAD than compared to non-veterans. The greater compromise in peripheral vascular measures in veterans is particularly noteworthy given that the prevalence of diabetes, hypertension, and dyslipidemia were not higher.
Measuring the physical in physical attractiveness: quasi-experiments on the sociobiology of female facial beauty

Two quasi-experiments investigated the relation between specific adult female facial features and the attraction, attribution, and altruistic responses of adult males. Precise measurements were obtained of the relative size of 24 facial features in an international sample of photographs of 50 females. Male subjects provided ratings of the attractiveness of each of the females. Positively correlated with attractiveness ratings were the neonate features of large eyes, small nose, and small chin; the maturity features of prominent cheekbones and narrow cheeks; and the expressive features of high eyebrows, large pupils, and large smile. A second study asked males to rate the personal characteristics of 16 previously measured females. The males were also asked to indicate the females for whom they would be most inclined to perform altruistic behaviors, and select for dating, sexual behavior, and childrearing. The second study replicated the correlations of feature measurements with attractiveness. Facial features also predicted personality attributions, altruistic inclinations, and reproductive interest. Sociobiological interpretations are discussed.
Distribution and morphology of luteinising hormone‐releasing hormone neurones in a species of wild antelope, the Springbok (Antidorcas marsupialis)

The distribution and morphology of luteinising hormone‐releasing hormone (LHRH) neurones varies between species. The primary purpose of this study was to characterize the distribution and morphology of the LHRH system in a species of antelope, the springbok. This wild antelope has a well‐defined social structure in which reproductive activity is confined to a few dominant, territorial rams. We also sought to determine whether social or reproductive status could be accounted for by differences in the distribution or morphology of hypothalamic LHRH neurones. Eleven anoestrous female, nine breeding territorial male (TM) and eight “bachelor” male (BM) springbok were obtained, and their reproductive and body conditions were assessed. By using standard immunocytochemical techniques, the LHRH system was visualised in the brains of four animals from each group. Immunoreactive neurones were located in a continuum from the septum to the arcuate nucleus, with the majority at the level of the organum vasculosum of the lamina terminalis. Neither the distribution nor the number of cells differed among the three groups. Furthermore, the area of LHRH perikarya was similar in both groups of males, suggesting that reproductive differences between TMs and BMs lie at another level of the neuroendocrine axis. The anoestrous females had significantly larger neurones than males (TM plus BM). This may reflect a sex difference in the LHRH system of this wild antelope. However, an alternative explanation is that the male/female difference is related to the comparatively inactive reproductive neuroendocrine state of the females. J. Comp. Neurol. 389:444–452, 1997. © 1997 Wiley‐Liss, Inc.
On the scores and degrees in hypertournaments

Abstract A k-hypertournament H = (V, A), where V is the vertex set and A is an arc set, is a complete k-hypergraph with each k-edge endowed with an orientation, that is, a linear arrangement of the vertices contained in the edge. In a k-hypertournament, the score si(losing score ri) of a vertex is the number of edges containing vi in which vi is not the last element(in which vi is the last element) and the total score of a vertex vi is ti = si − ri. For v ∈ V we denote dH+=∑a∈Hρ(v,a) $d_H^ + = \sum\limits_{a \in H} {\rho (v,a)} $ (or simply d+(v)) the degree of a vertex where, ρ(v, a) is k − i if v ∈ a ∈ A and v is the ith entry in a, otherwise zero. In this paper, we obtain necessary and sufficient conditions for a k-hypertournament to be degree regular. We use the inequalities of Holder and Chebyshev from mathematical analysis to study the score and degree structure of the k-hypertournaments.
Metastatic ampullary adenocarcinoma presenting as a hydrocele: a case report.

CONTEXT Metastases from ampullary malignancies are common, but spread to the testicle and paratesticular tissue is exceedingly rare with only 2 reported cases in the literature. CASE REPORT We report a case of a 70 year-old male with a history of ampullary adenocarcinoma status post pancreaticoduodenectomy who presented with a symptomatic right-sided hydrocele. Subsequent pathology revealed metastatic ampullary adenocarcinoma. CONCLUSIONS Metastasis to the testicle and paratesticular tissue from ampullary malignancies is rare, but must be considered in the evaluation of scrotal masses in patients with a history of ampullary malignancy.