Miracle-dz/UniFAR-FTUs huggingface dataset:
Coupling of Bacterial Endosymbiont and Host Mitochondrial Genomes in the Hydrothermal Vent Clam Calyptogena magnifica

ABSTRACT The hydrothermal vent clam Calyptogena magnifica (Bivalvia: Vesicomyidae) depends for its nutrition on sulfur-oxidizing symbiotic bacteria housed in its gill tissues. This symbiont is transmitted vertically between generations via the clam's eggs; however, it remains uncertain whether occasionally symbionts are horizontally transmitted or acquired from the environment. If symbionts are transmitted strictly vertically through the egg cytoplasm, inheritance of symbiont lineages should behave as if coupled to the host's maternally inherited mitochondrial DNA. This coupling would be obscured, however, with low rates of horizontal or environmental transfers, the equivalent of recombination between host lineages. Population genetic analyses of C. magnifica clams and associated symbionts from eastern Pacific hydrothermal vents clearly supported the hypothesis of strictly maternal cotransmission. Host mitochondrial and symbiont DNA sequences were coupled in a clam population that was polymorphic for both genetic markers. These markers were not similarly coupled with sequence variation at a nuclear gene locus, as expected for a randomly mating sexual population. Phylogenetic analysis of the two cytoplasmic genes also revealed no evidence for recombination. The tight association between vesicomyid clams and their vertically transmitted bacterial endosymbionts is phylogenetically very young (<50 million years) and may serve as a model for the origin and evolution of eukaryotic organelles.
Cardioprotection and Second Malignant Neoplasms Associated With Dexrazoxane in Children Receiving Anthracycline Chemotherapy: A Systematic Review and Meta-Analysis.

BACKGROUND Several randomized controlled trials (RCTs) have demonstrated that dexrazoxane reduces anthracycline cardiotoxicity in adults, but use in children has been hindered by lack of direct evidence of cardioprotection and concerns regarding second malignant neoplasms (SMNs). This study aimed to systematically review the evidence regarding dexrazoxane in children. METHODS We searched Medline, Embase, the Cochrane Library, and abstracts for RCTs and nonrandomized studies (NRSs) that compared dexrazoxane to no cardioprotection among children. We combined findings using random-effects models. All statistical tests were two-sided. RESULTS Eleven eligible publications reported results from five RCTs (1254 patients), and 15 publications reported results from 12 NRSs (3385 patients). Dexrazoxane did not impact clinical cardiotoxicity in RCTs because of a low cardiotoxic event rate (three events among all patients) but was associated with a reduction in subclinical cardiotoxicity. Among NRSs, dexrazoxane was associated with a reduction in clinical cardiotoxicity (relative risk (RR) = 0.29, P = . 001) and clinical+subclinical cardiotoxicity (RR = 0.43, P < .001). Among RCTs, 17 of 635 (2.7%) patients treated with dexrazoxane developed an SMN compared with seven of 619 (1.1%) who did not receive dexrazoxane (RR = 2.37, P = .06). Two RCTs that used concurrent etoposide reported an increased risk of acute myeloid leukemia, while one that used cranial radiation reported an increased risk of brain tumors. Event-free survival did not differ (P = .91). CONCLUSION Dexrazoxane is associated with a statistically significant risk reduction for most cardiotoxic outcomes. Dexrazoxane is associated with a statistically borderline increase in SMNs, possibly because of an interaction with concurrent cancer therapies. The decision to use dexrazoxane in children should balance the risks of cardiotoxicity and SMNs specific to each treatment protocol.
Oral pharmacokinetics and in‐vitro metabolism of metyrapone in male rats

The purpose of this study was to investigate the pharmacokinetics of a single oral administration of metyrapone (MP) and metabolites produced from it in male Wistar rats, and the major tissues and enzymes involved in the production of the MP metabolites. Furthermore, the MP metabolism in human liver subcellular fractions was compared with that in rats.
The negative impact of family ownership structure on firm value in the context of Indonesia

A number of studies concluded that family ownership structure increased firm's performance and also firm value. However, the benefit of family ownership will elapse when the opportunity to expropriate minority exists (Jiang and Peng, 2011). According to Claessen et al. (2000), higher entrenchment occurred in Indonesia, together with Philippines and Thailand. As of 16.6% of Indonesia's public companies was controlled by family as a single majority shareholder, on the other hand, the low law enforcement and the lowest corruption index are another fact in Indonesia. In such a condition it is expected that family ownership has a negative impact on firm value. Using big capitalisation public companies listed in Indonesia Stock Exchange (IDX) as a research sample, this study supports the hypothesis that there is a negative impact of family ownership on firm value, at the significance level of 10%.
Trading Patterns and Market Integration in Overlapping Experimental Asset Markets

Abstract This paper examines trading patterns and market integration using laboratory asset markets. Our markets are designed to approximately correspond to the trading day for stocks cross-listed in markets in Europe and North America. Some of our markets feature timing restrictions so that participants cannot trade across markets except during a fully integrated overlap period. Comparison of markets with and without timing restrictions shows that restrictions reduce trading activity and shift transactions to the overlap period. When asset values are extreme, price discovery can be impeded when trading restrictions exist. The measurement of liquidity suggests that trading restrictions increase overall spreads.
Safe use of highly steatotic livers by utilizing a donor/recipient clinical algorithm

The aim of this study was to assess the long‐term safety and clinical outcomes associated with the utilization of highly steatotic donor livers utilizing a specific donor/recipient matching algorithm. This was a prospective, observational, single‐center, 10‐yr follow‐up study. Highly steatotic livers were utilized according to a donor/recipient algorithm that guided the surgeon to use highly steatotic donor organs judiciously in low‐risk recipients. This study initially compared fat assessment based on frozen‐section Ehrlich's hematoxylin and eosin (H&E) to reperfusion biopsy fat assessment and demonstrated that H&E is an insensitive analysis to determine degree of steatosis. Patients were divided into three groups based on donor steatosis (group 1: <30% steatosis, group 2: 30–60% steatosis, group 3: >60% steatosis), and clinical outcomes were assessed. One hundred and sixteen patients were included in the analysis. Patients that received severely steatotic livers (>60% fat) showed increased reperfusion liver injury and delayed return of liver function in the early postoperative period, demonstrated by biochemical markers. However, there were no differences in primary non‐function, postoperative complications, length of stay, and patient and graft survival. Using rigorous donor/recipient matching through a detailed algorithm, these data demonstrate that normal liver allograft outcomes are not superior to those in highly steatotic grafts.
Rapid eye movement sleep does not seem to unbind memories from their emotional context

Sleep unbinds memories from their emotional learning context, protecting them from emotional interference due to a change of mood between learning and recall. According to the ‘sleep to forget and sleep to remember’ model, emotional unbinding takes place during rapid eye movement sleep. To test this hypothesis, we investigated emotional contextual interference effects after early versus late post‐learning sleep periods, in which slow wave and rapid eye movement sleep, respectively, predominate. Participants learned a list of neutral word pairs after induction of a happy or a sad mood, then slept immediately afterwards for 3 h of early or late sleep under polysomnographic recording, in a within‐subject counterbalanced design. They slept for 3 h before learning in the late sleep condition. Polysomnographic data confirmed more rapid eye movement sleep in the late than in the early sleep condition. After awakening, half the list was recalled after induction of a similar mood than during the encoding session (non‐interference condition), and the other half of the list was recalled after induction of a different mood (interference condition). The results disclosed an emotional interference effect on recall both in the early and late sleep conditions, which does not corroborate the hypothesis of a rapid eye movement sleep‐related protection of recent memories from emotional contextual interference. Alternatively, the contextual demodulation process initiated during the first post‐learning night might need several consecutive nights of sleep to be achieved.
Role of Preoperative Administration of Vitamin D and Calcium in Postoperative Transient Hypocalcemia after Total Thyroidectomy

Introduction Thyroid surgery is one of the most frequently performed surgical procedures worldwide. Total thyroidectomy is a recommended procedure for most of the thyroid diseases. The most common complication resulting after this surgery is transient hypocalcemia - the incidence is 24% - which increases the morbidity rate and increases the length of stay in the hospital. The objective of our study was to compare the frequency of transient hypocalcemia after vitamin D and calcium supplementation with the control group for patients undergoing total thyroidectomy. Patients and methods It was a randomized controlled trial conducted at Department of Surgery, Pakistan Atomic Energy Commission General Hospital, Islamabad, Pakistan from January 2017 to July 2017. A total of 92 patients of both genders undergoing total thyroidectomy were included in the study. Patients undergoing reoperation for thyroid disease, American Society of Anesthesiologists (ASA) grade 3 or above, patients with chronic renal failure, preoperative hypocalcemia or hypercalcemia were excluded. The patients were sorted into two groups by lottery method; Group 1 in which Vitamin D (2,00,000 IU) and calcium (1 gm) was given 24 hours preoperatively. Group 2 was the control group. Total thyroidectomy was done and serum calcium levels were evaluated immediately after surgery on day two, seven and on the 30th day. The final outcome was measured at one month. Data was analyzed via the Statistical Package for Social Sciences version 22.0 (IBM Corp, Armonk, NY, USA). P value ≤ 0.05 was considered significant. Results The age ranged from 18 to 65 years with the mean age of 38.673 ± 8.63 years in group 1 while 41.217 ± 9.52 years in group 2, mean preoperative calcium level was 9.482 ± 0.49 mg/dl in group 1 and 9.678 ± 0.54 mg/dl in group 2. Hypocalcemia was seen in 3 (6.5%) in group 1 as compared to 12 (26.1%) patients in group 2 (p = 0.011). Conclusion Preoperative oral calcium and vitamin D supplements may prevent postoperative hypocalcemia, allowing a safe and early discharge. This will ultimately lead to improved patient satisfaction and significant cost savings.
Epidemiology and antibiotic sensitivity pattern of asymptomatic bacteriuria during pregnancy: A cross-sectional study

Background: Asymptomatic bacteriuria (ASB) during pregnancy is associated with significant maternal and fetal complications. Continuous monitoring of antibiotic sensitivity pattern of bacterial isolates is required for appropriate management of ASB. Aims: The study aims to assess the prevalence, risk factors, and antibiotic sensitivity profile of ASB during pregnancy. Materials and Methods: A cross-sectional, hospital-based study was conducted in the pregnant women attending Obstetrics and Gynecology Department of a tertiary care hospital. A suitably designed data collection form was used to collect sociodemographic profile, obstetric history, and illnesses suffering from the participants. Urine specimens of the participants were processed for isolation and identification of bacterial species. Kirby–Bauer disc diffusion test was used to screen antibiotic sensitivity of the isolated bacteria. Statistical Analysis: Descriptive statistics were used to represent the sociodemographic data. Chi-square test was used to associate risk factors for the development of ASB during pregnancy. Results: A total of 1332 women were participated in the study. The prevalence of ASB among pregnant women was 86 (6.4%) and Escherichia coli (58; 67.4%) was the most predominant bacteria. Meropenem, cephalosporin's, and gentamycin were shown higher sensitivity in ASB. Advanced age, illiteracy, rural residency, multigravida, multiparity, history of abortion, and medical illnesses were strongly associated to develop ASB during pregnancy. Conclusion: E. coli were the most predominant isolated uropathogen in ASB. The study observed that there is a wide variation in the antibiotic sensitivity pattern of isolated organisms. Hence, there is a need of routine urine culture sensitivity screening in pregnant women for rational use of antibiotics and to reduce the antibiotic resistance.
Adaptive-VNE: A flexible resource allocation for virtual network embedding algorithm

In this paper, we propose a new dynamic adaptive virtual network resource allocation strategy named Adaptive-VNE to deal with the complexity and the inefficiency of resource allocation. The proposal coordinates virtual node and virtual link mapping stages. The main idea behind the proposal is take advantage of unused bandwidth with respect to the occupancy rate of embedded virtual links. Hence, the unused bandwidth will be reassigned to incoming virtual network requests. To do so, Adaptive-VNE adopts the “divide and conquer” strategy. It divides the virtual network request topology into many star topologies. Then, the mapping of each piece within the whole topology is formulated as a K-supplier problem and resolved by an approximation bottleneck algorithm. To generate the global virtual network topology, Adaptive-VNE uses a backtracking algorithm in order to minimise the global mapping cost. Note that the proposal forecasts usage rate of virtual links and adapts their bandwidth reservation. Adaptive-VNE was validated by simulations and compared to the related strategies found in literature. The results obtained show that, contrarily to static bandwidth allocation approaches, the adaptive strategy maximises substrate bandwidth usage while the virtual links' bottleneck rate is minimised. Moreover, the congestion periods are minimised and during the bottleneck the bandwidth satisfaction is maximised. Finally, Adaptive-VNE improves performances in terms of acceptance rate of virtual networks and revenue of infrastructure providers.
Ranked set sampling for efficient estimation of a population proportion

Ranked set sampling (RSS) is a sampling procedure that can be considerably more efficient than simple random sampling (SRS). It involves preliminary ranking of the variable of interest to aid in sample selection. Although ranking processes for continuous variables that are implemented through either subjective judgement or via the use of a concomitant variable have been studied extensively in the literature, the use of RSS in the case of a binary variable has not been investigated thoroughly. In this paper we propose the use of logistic regression to aid in the ranking of a binary variable of interest. We illustrate the application of RSS to estimation of a population proportion with an example based on the National Health and Nutrition Examination Survey III data set. Our results indicate that this use of logistic regression improves the accuracy of the preliminary ranking in RSS and leads to substantial gains in precision for estimation of a population proportion. Copyright © 2005 John Wiley & Sons, Ltd.
Azole resistance in Aspergillus fumigatus: a growing public health concern.

PURPOSE OF REVIEW Reports from the end of the 2000s forced the medical community to take azole resistance in Aspergillus fumigatus into account. Not only patients with chronic aspergillus disease, who develop resistance during long-term azole treatment, but also azole-naive patients are at risk, owing to the presence of resistant strains in the environment. The purpose of this review is to overview the latest findings concerning the origin, evolution, and implications of azole resistance in A. fumigatus. RECENT FINDINGS TR34/L98H is the predominant resistance mechanism of environmental origin in A. fumigatus. Recent epidemiological data show that this mechanism is an expanding problem, with reports from China, Iran, and India. However, the TR34/L98H strains from the Middle East are genotypically different from the European isolates; their emergence is, therefore, not due to simple geographical spread of the 'European' isolates. A new environmental resistance mechanism, TR46/Y121F/T289A, was detected in the Netherlands, conferring voriconazole resistance. In patients chronically treated with triazoles, the spectrum of resistance has become more diverse, with the emergence of non-CYP51A-mediated mechanisms. Central registration of treatment and outcome data of patients with resistant aspergillus disease are needed. SUMMARY Azole resistance in A. fumigatus is evolving to a global health problem.
Preparation of Efficient BiOBr/MIL‐88B(Fe) Composites with Enhanced Photocatalytic Activities

In this study, a novel composite containing an iron based metal‐organic framework (MOF) and BiOBr was successfully synthesized by a simple method, and was fully characterized by X‐ray diffraction patterns, Fourier transform infrared spectra, UV‐vis diffuse reflectance spectra, and transmission electron microscopy. Moreover, the photocatalytic activities of BiOBr/MIL‐88B(Fe) composites and the pure materials were evaluated by measuring the degradation of Rhodamine B under visible light. The results show that the composite exhibits better photocatalytic activities than pure materials, which can be ascribed to the high adsorption capacity of MIL‐88B(Fe) and the enhanced separation of photogenerated charge carriers from assembly of MIL‐88B(Fe) on BiOBr. And the effects of various operating parameters such as catalyst dosage, medium pH, the mass ratio of BiOBr, and MIL‐88B(Fe) and the dye initial concentration on the degradation of RhB have been studied.
Mobile Device use in the Classroom: High School Students’ Experiences and Perceptions

As mobile devices (e.g. tablets, iPads, iPods, smart phones, and laptops) become more ubiquitous, many students find themselves carrying a personal mobile device to school every day. This action research study examined mobile device use among high school students. Main findings about current trends in mobile reflected three themes: (a) looking up words, (b) research, and (c) text messaging. Findings related to high school students’ perceptions about mobile devise use also reflected three themes: (a) easy, (b) fast, and (c) enjoyable. The voices of mobile learners provide support for each theme, reflecting an authentic account that teachers and administrators might consider when implementing mobile use to enhance learning. While this study showed that high school students typically approve of their mobile learning experiences, implications for further research are conveyed.
Skewness Preference Across Countries

Prospect theory implies that assets with positively skewed returns should be traded at premium to assets with negative skewness. We hypothesize that in the integrated financial markets this concept should also hold for the entire country equity portfolios. This article examines the linkages between the country-level expected returns and past skewness. We evidence a robust negative relationship between skewness and future returns. The phenomenon is most significant within large, liquid, developed, and open stock markets. Additional sorts on skewness can improve performance of both cross-country value and momentum strategies. The study is based on the sorting and cross-sectional tests conducted within a sample of 78 country equity markets for years 1999-2014.
Sexual Dysfunction After Colpectomy and Vaginal Reconstruction With a Vertical Rectus Abdominis Myocutaneous Flap

BACKGROUND: The use of the vertical rectus abdominis myocutaneous flap in reconstruction after abdominoperineal resection or pelvic exenteration for neoplasia is well documented. However, functional outcomes after vaginal reconstruction, including sexual function, are poorly described. OBJECTIVE: This study aimed to examine sexual function in women following extensive pelvic surgery with colpectomy and vaginal reconstruction with the use of a vertical rectus abdominis myocutaneous flap. DESIGN: This study is a retrospective review of medical records in combination with patient questionnaires. Nonresponders were followed up with a second contact. SETTINGS: This study was performed at a tertiary care university medical center (Colorectal Section, Department of Surgery P, Aarhus University Hospital, Denmark) PATIENTS All women undergoing pelvic surgery and simultaneous vaginal reconstruction with the use of a vertical rectus abdominis myocutaneous flap between 2004 and 2010 at our department were identified from a patient database. Thirty women who were alive at the time of identification were included in the study. MAIN OUTCOME MEASURES: Sexual function before and after surgery was evaluated by the use of the Sexual function Vaginal changes Questionnaire. The main outcome end point was whether the patient was sexually active after vaginal reconstruction. RESULTS: Twenty-six participants (87%) answered the questionnaire. Fifty percent of patients reported an active sex life before surgery. In general, patients reported an unchanged desire for both physical and sexual contact after surgery. However, only 2 patients (14%) reported being sexually active after surgery. LIMITATIONS: This was a retrospective study with a heterogeneous cohort involving several types of cancers and surgical procedures. Factors other than vertical rectus abdominis myocutaneous flap reconstruction itself may interfere with the sexual function. CONCLUSION: Extensive pelvic surgery with colpectomy leads to sexual dysfunction even when the vagina is reconstructed with a vertical rectus abdominis myocutaneous flap. This knowledge may improve the quality of information given to this group of patients before surgery.