Miracle-dz/UniFAR-FTUs huggingface dataset:
Developing Gender-Specific Gene Expression Biodosimetry Using a Panel of Radiation-Responsive Genes for Determining Radiation Dose in Human Peripheral Blood.

In a large-scale radiological incident, rapid and high-throughput biodosimetry would be needed. Gene expression-based biodosimetry is a promising approach to determining the dose received after radiation exposure. We previously identified 35 candidate genes as biodosimetry markers based on a systematic review. The goal of the current study was to establish and validate a specific gene expression-based radiological biodosimetry using a panel of highly radioresponsive genes in human peripheral blood for improving the accuracy of dose estimation. Human peripheral blood samples from 30 adult donors were irradiated to 0, 0.5, 1, 2, 3, 4, 6 and 8 Gy with 60Co γ rays at a dose rate of 1 Gy/min. We examined the expression patterns of candidate genes using real-time polymerase chain reaction (qRT-PCR) at 6, 12, 24 and 48 h postirradiation. Stepwise regression analysis was employed to develop the gene expression-based dosimetry models at each time point. Samples from another 10 healthy donors (blind samples) and four total-body irradiated (TBI) patients were used to validate the radiation dosimetry models. We observed significant linear dose-response relationships of CDKN1A, BAX, MDM2, XPC, PCNA, FDXR, GDF-15, DDB2, TNFRSF10B, PHPT1, ASTN2, RPS27L, BBC3, TNFSF4, POLH, CCNG1, PPM1D and GADD45A in human peripheral blood at the various time points. However, the expression levels of these genes were affected by inter-individual variations and gender. We found that the gender-dependent regression models could explain 0.85 of variance at 24 h postirradiation and could also accurately estimate the absorbed radiation doses with dose range of 0-05 Gy, in human peripheral blood samples irradiated ex vivo and from TBI patients, respectively. This study demonstrates that developing gender-specific biodosimetry based on a panel of highly radioresponsive genes may help advance the application of gene expression signature for dose estimation in the event of a radiological accident or in clinical treatment.
The prognostic value of Skp 2 expression level in cancer : a meta-analysis

Purpose: S-phase kinase-associated protein 2 (Skp2) is overexpressed in many types of cancers and might be a potential cancer prognostic biomarker. Several studies reported an association between Skp2 expression level and tumor prognosis; however, the results were inconsistent and inconclusive. The present study is a metaanalysis carried out to assess the association between Skp2 expression and tumor prognosis in accordance with the guidelines of the Preferred Reporting Item for Systematic Reviews and Meta-analyses. Methods: Until April 30, 2016, 35 articles were collected, representing 5,514 patients. Hazard ratio (HR) and 95% confidence intervals (CIs) were used to assess the association between Skp2 expression and survival outcome and estimated using fixedor random-effects models when appropriate. The statistical significance of the pooled HR was determined by a Z-test. The statistical heterogeneity within studies was detected with the Chi-squared based Q-test and I2 metric. The publication bias was also assessed by Egger’s and Begg’s tests. Sensitivity analysis was also carried out. STATA version 11.0 was used for all statistical analyses. Results: Results suggested that Skp2 overexpression is associated with poor overall survival (OS) and DFS/RFS in all cancer patients as well as in subgroup analysis. Skp2 localized in the cytoplasm was not associated with prognosis. Conclusion: Skp2 might be a predictive and independent marker of cancer prognosis.
Nonlinear mean reversion in the consumption-income ratio: New evidence from the OECD countries

Whether or not the average propensity to consume (APC) is a non-stationary process has important theoretical implications. If the APC exhibits mean reversion, then this implies that an equilibrium relationship exists between consumption and income. In this article we examine whether or not the consumption-income ratios of twenty OECD countries can be characterized by a stationary process with a non-linear trend and asymmetric adjustment. For this purpose, we employ Chen and Xie‟s (2015) new tests. Among the main results, it is found that the consumption-income ratios of these OECD countries are stationary after taking into account asymmetry and the non-linear trend in the long run. Our results are in line with the validity of some consumption theories such as the relative income hypothesis, the permanent income hypothesis, and the life cycle hypothesis.
Age and fecundity in Salamandra algira (Caudata: Salamandridae)

Amphibians are characterised by potentially indefinite growth. Their body size reflects a trade-off between growth and reproduction. Consequently, growth decreases or even ceases after maturation. Furthermore, the sexes often mature at different ages (sexual bimaturity). We examined fecundity patterns of the terrestrial salamander Salamandra algira (Salamandridae) and tested if age, body size and the fecundity of both sexes are connected and how these reproductive traits interact. We revealed positive correlations for female size, age and fecundity traits, i.e., egg number and volume. The male number of testes lobes was also positively correlated with age. Our study provides basic data on a rarely studied terrestrial salamandrid. Further collection-based research is needed to obtain additional data aiding the understanding of life history evolution of the Salamandridae.
BEHAVIOR IN MALAYSIA ’ S KNOWLEDGE INTENSIVE BUSINESS SERVICES

This study was conducted to investigate the relationship between pro-innovation organizational climate and innovative work behavior among the knowledge workers of the knowledge intensive business services in Malaysia. The innovative work behavior has a central role in the development of knowledge-intensive business services in Malaysia. It was previously reported that pro-innovation organizational climate to have a significant relationship with innovative work behavior of employees in various business sectors. However, not all support the notion that organizational climate correlates with innovative work behavior. Some of the researchers concluded the relationship is rather weak. This makes it even more interesting to include organizational climate in the research framework of the model of innovative work behavior in Malaysia. A quantitative method was utilized and data were collected using mail survey. A total of 1520 questionnaires were distributed and 310 deemed usable for analysis using SPSS, resulted in 20.6 % response rate. The results revealed that there was a significant relationship between pro-innovation organizational climates and the innovative work behavior of knowledge workers in Malaysia.
REVISION 1 : Ab initio investigations of 1 dioctahedral interlayer-deficient mica : Modeling 2 particles of illite found within gas shale

5 The focus of the study presented here is the illite component of the clay mineral 6 components found within gas shale, specifically the creation of robust, atomistic 7 models of illite particles bearing characteristics of the 2M1 polytype. The template 8 for the illite models is derived from crystallographic data, which is used together 9 with the general formula, K1.67(Al3.29Fe0.38Mg0.32)[(Si6.68 Al1.32)O20(OH)4] to create 10 different particles of illite, each containing potassium plus either ammonium (NH4 ) 11 ∗Email: geatches@stanford.edu 1 or hydronium (H3O ) ions, or water molecules in two different proportions. These 12 atomistic models are optimized from first principles using plane waves and pseudo 13 potentials within the formalism of density functional theory (DFT). The resulting 14 lattice lengths, lattice dynamics in the form of infrared frequencies, positions of 15 interlayer molecules and simulated X-ray powder diffraction (XRPD) patterns are 16 analyzed with reference to the available experimental data. We conclude that all four 17 illite models display properties that fall within the range of available experimental 18 data, and that therefore these are state-of-the-art atomistic illites, ready for use in 19 further studies. Furthermore, the analytical data from these models will enable the 20 characterization of physical samples of illite with varying interlayer constituents. 21
Convenience Rating of Post-disaster Recovery Housing Complexes Constructed in Iwate Prefecture following the 2011 Tohoku Earthquake

This study evaluated the convenience of postdisaster recovery housing complexes constructed in Japan’s Iwate Prefecture following the 2011 Tohoku Earthquake. We expected that five years on from the disaster, the evacuees would find life there more convenient. The study was targeted at three major cities in the southern coastal area of Iwate Prefecture that were most heavily struck by the earthquake-triggered tsunami: Kamaishi, Ofunato, and Rikuzentakata. Using geographical information system software, we conducted a network analysis of the coordinate data on the location of crucial infrastructure. Housing complexes within the defined service area of each infrastructure facility were assigned a score of 10, while those within two and three times the defined service area were assigned scores of 5.0 and 3.3, respectively. The convenience of the housing complexes was evaluated using these scores. In Ofunato City, the post-disaster recovery housing complexes were shown to have better access to key infrastructure than the temporary housing complexes, and in Rikuzentakata City, the two types of complexes were shown to have comparable access. In Kamaishi City, however, the post-disaster recovery housing complexes were shown to have poorer access to key infrastructure than the temporary housing complexes. These results suggest that the daily life of evacuees has not greatly improved in Rikuzentakata and Kamaishi. These results were not in line with our prior expectations.
THE EFFICACY OF A KILLED VACCINE AGAINST PARATUBERCULOSIS ( SILIRUM ® ) IN CATTLE . A FIELD STUDY

García-Pariente C, Pérez V, Geijo MV1, Moreno O, Muñoz M, Fuertes M, Puentes E2, Doce J2, Ferreras MC, García Marín JF 8ICP 2005 Dpt. Patología Animal: Medicina Animal (Anatomía Patológica), Facultad de Veterinaria, Universidad de León, Campus de Vegazana s/n, 24071 León. Spain; 1NEIKER, Derio, Bizkaia, Spain; 2CZ Veterinaria S. A. , Porriño, Pontevedra, Spain 8th International Colloquium on Paratuberculosis ICP 2005 TRIALS
Elkabets-Mutant Breast Cancer PIK 3 CA Inhibitors in α mTORC 1 Inhibition Is Required for Sensitivity to PI 3 K p 110

will not be something to beware of, but something to monitor and target with specific drugs. setting as well. Some mTOR inhibitors are already available for use in patients, so hopefully soon mTOR activation would be to confirm that adding mTOR inhibition to treatment regimens for these cancers is effective in the clinical combination treatments have only been tested in cells and in mouse models thus far. Thus, the next critical step In both studies, the activation of mTOR in drug-resistant tumors has been confirmed in human patients, but the regimen can block drug resistance and kill the cancer cells. drug-resistant melanomas also have persistent activation of mTOR, and adding an mTOR inhibitor to the treatment mixed results, because melanomas quickly develop resistance to these drugs. Now, the authors have shown that BRAF-mutant melanomas, the most common type, are frequently treated with RAF and MEK inhibitors, but only with . found a similar mTOR-dependent drug resistance mechanism to be active in melanoma as well. et al Corcoran treatment regimen could reverse the resistance and kill the tumor cells. persistently active mTOR signaling, both in cultured cell lines and in patient tumors. Adding an mTOR inhibitor to the to these drugs. The authors have discovered that breast cancers resistant to the PI3K inhibitor BYL719 had ) are currently in clinical trials, but some of the cancers are resistant PIK3CA Inhibitors of PI3K (the protein product of gene is frequently mutated. PIK3CA Elkabets and coauthors were working on breast cancer, where the combination treatments that block resistance to targeted cancer drugs by inhibiting mTOR. drugs just when they seem to be working perfectly. Now, two groups of researchers have developed rational cancer cells. Unfortunately, tumors are often a step ahead of the scientists, becoming resistant to these targeted In recent years, numerous new drugs have been developed to take advantage of specific molecular changes in Caveat mTOR
EPA & 3 eme Cycle Fribourg 2002 : Freshwater and brackish ( palaeo ) ecosystems New approaches investigating freshwater palaeoecosystems

Ecosystems are complex, self regulating interacting systems of communities and their abiotic environments (ELLENBERG 1973). But due to taphonomic and diagenetic processes only palaeocommunities are describable from the fossil record (BOY 1998). In this sense palaeoecosystems are complex interacting systems of palaeocommunities and abiotic environmental parameters. They show the following biotic features (SCHULZE & MOONEY 1993, BOY 1998): ecological structure, ecological function and biodiversity. The ecological structure is determined by energy flow, what means that it is an interaction between all biotic components of the system (= synecology) and can be described through the trophic interactions (food chains, predator-prey interactions). Because of time averaging, succession is the only detectable (palaeo-) ecological function (BOY 1998). Palaeoecosystems analyses means therefore to investigate the biodiversity, trophic interaction and succession within and between palaeocommunities in relation to the abiotic environment. An important precondition for the analyses of palaeoecosystems is the reconstruction of the palaeocommunity. To reveal the taphonomic processes (diagenesis, time averaging, biostratinomy,) is an important first step. To detect autochthon/parautochthon components within a taphocoenosis a new method is presented which is based on teeth replacement quotients of cyprinid fishes and allows to distinguish sediments from permanent water bodies with an autochthon fish community (limnic and fluvial sediments) from sediments of temporal water bodies (pedogenic sediments, pond and floodplain sediments) with parautochthon/allochthon fishes. The investigation of 51 outcrops within the Upper Freshwater Molasse (Middle Miocene, Bavarian Molasse Basin) resulted in 21 localities with permanent water conditions, 27 with temporal water conditions (3 localities with uncertain conditions).
EXPERIENCE WITH EUROPEAN PERCH ( PERCA FLUVIATILIS L . ) LARVAL REARING IN CONTROLLED CONDITIONS

European perch have been reared for centuries, but only in extensive culture, where it represents about 2-5% of production in polyculture cyprinid ponds (KESTEMONT et al., 1996). The potential market for perch is estimated at 5 000 to 10 000 tons per year in Europe (MÉLARD et al., 1995). With regard to recent development in research aimed at intensifying production of the different stages of perch, it appears that the production cost of fingerlings is one of major bottlenecks for the intensification of commercial culture of this species. The small size and fragility of the larvae and their dependence on live food are usually cited as limiting factors. Cannibalism has also been evidenced as a major factor reducing the survival rate during larval and post-larval stages of European perch (KESTEMONT et al., 1996). In order to meet the optimal rearing conditions of this critical developmental stage, it is necessary to better understand the ontogeny of digestive system, the nutritional requirements and the effects of different biochemical parameters on survival and growth of perch larvae.
Automatic Speech Recognition Using Deep Neural Networks: New Possibilities

Recently, automatic speech recognition (ASR) systems that use deep neural networks (DNNs) for acoustic modeling have attracted huge research interest. This is due to the recent results that have significantly raised the state of the art performance of ASR systems. This dissertation proposes a number of new methods to improve the state of the art ASR performance by exploiting the power of DNNs. The first method exploits domain knowledge in designing a special neural network (NN) structure called a convolutional neural network (CNN). This dissertation proposes to use the CNN in a way that applies convolution and pooling operations along frequency to handle frequency variations that commonly happen due to speaker and pronunciation differences in speech signals. Moreover, a new CNN structure called limited weight sharing is proposed to better suit special spectral characteristics of speech signals. Our experimental results have shown that the use of a CNN leads to 6-9% relative reduction in error rate. The second proposed method deals with speaker variations in a more explicit way through using a new speaker code based adaptation. This method adapts the speech acoustic model to a new speaker by learning a suitable speaker representation based on a small amount of adaptation data from each target speaker. This method alleviates the need to modify any model parameters as is done with other commonly used adaptation methods for neural networks. This greatly reduces the number of parameters to estimate
INFLUENCE OF SODIUM CHLORIDE ONTO GROWTH AND FLOWERING OF ISOTOMA AXILLARIS LINDL.

U. -WALORSKA, M. and A. KRZYMIŃSKA, 2016. Influence of sodium chloride onto growth and flowering of Isotoma axillaris Lindl. Bulg. J. Agric. Sci., 22: 79–83 To assess the effect of sodium chloride on growth and flowering of Isotoma axillaris their plants grew in pots filled with peat substrate and with sodium chloride. In 2011 the following dosages of sodium chloride were applied: 0, 5, 10, and 15 g.dm-3. In 2012 the dosages of sodium chloride were increased, and the following amounts were applied respectively: 0, 10, 20, and 30 g.dm-3. The presence of sodium chloride in the substrate diminished decorative qualities of the species under study, which included growth and flowering inhibition together with the decrease in the index of leaves greenness. Moreover, both the fresh and the dry matter of the plants decreased together with the increase in sodium chloride concentration in the substrate. This compound had also a negative influence onto the water percentage in the plants.
Olfaction and Maternal Behaviors in Rats

The research on maternal behaviors and maternal responsiveness is extensive. Maternal responsiveness in rats consists of retrieval of pups to the nest, grouping pups, building the nest, and licking and nursing of the pups. There are studies suggesting that audition, vision, olfaction, and vomeronasal (VNO) function play a role in the task of maternal responsiveness. Some research demonstrates that odors play no role in responsiveness while other research suggests odors are required (Alberts & Farrell 2002 b). The ability to recognize offspring has been credited to the olfactory epithelium as well as the VNO. The current research analyzed the role of the olfactory epithelium in offspring recognition and retrieval in female rats. Pups were placed in two treatment groups; one group was painted with citrus scented oil (containing volatile chemical odorants) on days two through six postpartum, the second group was painted with citrus oil on days seven through eleven postpartum. Pups were removed from the nest and dispersed throughout the home cage. The time it took mothers to retrieve dispersed pups back to the nest was measured. The treatment used contained volatile chemical odorants detected by the olfactory epithelium, which had no significant effect on maternal responsiveness and pup retrieval. From this research no evidence was found to support the hypothesis that the nasal epithelium plays a role in retrieval and recognition. Because the olfactory epithelium was found not to function in maternal responsiveness the findings support previous research suggesting the VNO as the main player in maternal responsiveness in rats. Olfaction and Maternal Behaviors
Gaseous , Heterogeneous , and Condensed-Phase Detonations DEFLAGRATION-TO-DETONATION TRANSITION IN ¢ GASEOUS OXYGEN LIQUID FUEL FILM £ SYSTEM

De§agration-to-detonation transition (DDT) in a channel with gaseous oxygen in the volume and a thin ¦lm of liquid n-heptane on the bottom wall has been obtained experimentally at weak ignition by a source, which generates the initial shock wave (SW) of insigni¦cant intensity. In a series of experiments with di ̈erent ignition energy (14 to 480 J) in a straight 3-meter long channel of rectangular cross section 54×24 mm with smooth internal walls and with one open end, the DDT in such a strati¦ed system was detected at run-up distances of 1 to 2 m from the ignition source and run-up time of 3.4 to 30 ms after ignition. In some experiments, a quasi-stationary low-speed detonation-like combustion front, traveling at an average velocity of 700900 m/s was detected with the structure including a leading SW followed by a reaction zone separated by a time delay of 80 to 150 μs.
A Parametric Approach to Turbine Tip Leakage Aerodynamic Investigation for Axial Flow Turbine

April 10-15, 2016 Abstract This current paper deals with the development of a computational system dealing with parametric assessment of aerodynamic losses near the tip region of a high pressure turbine blade. Performance of an axial flow turbine is strongly related to the flow structure in the tip gap between blade tip and casing. Flow structure in the tip gap is a significant source of inefficiency. Special emphasis is paid to developing a sufficiently accurate 3D RANS based loss estimation system for the optimization of tip section geometry. An HP turbine tip section will be optimized for minimum aerodynamic losses and also for minimized heat loss. The present study deals with a preliminary study of effective parametric grid generation and turbulent flow model implementation and assessment under realistically simulated turbine flow conditions. Initial development of this computational model is performed in a linear turbine cascade arrangement. Numerical experiments with parametrically generated multizone structured grid topologies and unstructured grids pave the way for the 3D optimization of the HP turbine blade tip region. The future efforts will include modified squealer tips, tip trenches and tip carving investigations in an effort to obtain optimal 3D tip shapes as far as aerodynamic losses and heat losses are concerned.
The cyclicality of markups and profit margins for the United Kingdom : Some new evidence

In this paper, we assess the cyclicality of mark-ups and profit margins within the United Kingdom, at both the aggregate and industry level. We find that the private-sector labour share moves countercyclically, suggesting that the aggregate mark-up moves procyclically. This result survives when we consider more sophisticated measures of the mark-up. And this result is also supported by industry level data. We find that the aggregate market-sector profit share moves procyclically and that the cyclical behaviour of profit margins is largely homogenous across industries. Nevertheless, there is some evidence that margins moved against the cycle in the late 1990s, starting to fall in 1997 whereas the cycle did not peak until until 2000. In tandem with these cyclical movements, we also find that the market-sector profit share has trended upwards since 1970, in contrast to the aggregate mark-up, which fell over the same period. * Bank of England, Threadneedle Street, London, EC2R 8AH. E-mail: clare.macallan@bankofengland.co.uk, stephen.millard@bankofengland.co.uk and miles.parker@bankofengland.co.uk. The views expressed in this paper are those of the authors, and not necessarily those of the Bank of England.