Miracle-dz/UniFAR-FTUs huggingface dataset:
OF THEORETICAL PERSPECTIVE ON FAMILY BUSINESS GOVERNANCE

The purpose of this paper is to review governance issue in family firms from several perspectives and discuss about the contribution of transaction cost theory to explain governance mechanism in family firm. In family business literature, the explanation about the governance mechanism movement can be found in Agency theory and Transaction cost Theory. Agency theory supports a foundation for understanding formal control mechanism through hierarchy within firm. Transaction cost economy frequently use to explain governance mechanism for formal control in inter-firm relationship By addressing governance issue in family SMEs, this study contributes to an understanding of connection between characteristic of family SMEs, economic business activities, environmental factors, and governance mechanism. Keyword: Theoretical Perspectives, Family Business
Immunological Effects and Viral Gene Expression Determine the Efficacy of Oncolytic Measles Vaccines Encoding IL-12 or IL-15 Agonists

Tumor-targeted immunomodulation using oncolytic viral vectors is currently being investigated as a promising strategy in cancer therapy. In a previous study, we showed that a measles virus Schwarz vaccine strain (MeVac) vector encoding an interleukin-12 fusion protein (FmIL-12) is an effective immunotherapy in the MC38cea murine colon adenocarcinoma model. We hypothesized that MeVac encoding interleukin-15 may mediate enhanced T and NK cell responses and thus increase the therapeutic efficacy, especially in NK cell-controlled tumors. Therefore, we generated MeVac vectors encoding an interleukin-15 superagonist, FmIL-15. Replication and oncolytic capacity, transgene expression, and functionality of MeVac FmIL-15 vectors were validated in vitro. Effects on the tumor immune landscape and therapeutic efficacy of both FmIL-12 and FmIL-15 vectors were studied in the MC38cea and B16hCD46 tumor models. Treatment with MeVac FmIL-15 increased T and NK cell infiltration in both models. However, MeVac FmIL-12 showed more robust viral gene expression and immune activation, resulting in superior anti-tumor efficacy. Based on these results, MeVac encoding a human IL-12 fusion protein was developed for future clinical translation.
Retinal Image Classification via Vasculature-Guided Sequential Attention

Age-related macular degeneration and diabetic retinopathy are diseases of increasing prevalence globally in recent years. Traditionally, diagnosing these diseases relied on manual visual inspection by experts, which was costly, time-consuming and laborious as it required closely examining high-resolution color fundus images. More recently, deep learning networks have shown great potential in predicting diseases from retinal images. However, being purely data-driven, these networks are susceptible to overfitting and their training requires large annotated data. In this paper, we propose to enrich deep learning-based fundus image classifiers with prior knowledge on special structures in the retina implicated with the disease. In particular, we leverage vessel priors to guide the attention mechanism of deep learning architectures. In addition, we leverage a bi-directional dual-layer LSTM module to learn the inter-dependencies between a sequence of prior-guided attention maps deployed across the depth of the disease classification network. Results on the clinical datasets show the proposed method could bring performance improvement by as much as 8%?
A Comparison of Exact and Heuristic Methods for a Facility Location Problem

We formulate a facility location problem where the demand of any single client must be allocated to a single facility and a prize is obtained by allocating the demand of a client to a certain facility, i.e. a prize-based variant of the Single Source Capacitated Facility Location Problem. For this problem we pursue both an exact approach through Integer Linear Programming and a heuristic approach based on a local search algorithm. We compare both approaches by considering 500+ instances. The heuristic approach allows to obtain a reduction of the computational time by a factor larger than 10 in 92% of instances and 100 in 64% of instances. The time reduction is obtained with a small sacrifice in the value of the objective function that is achieved, smaller than 10% in nearly 70% of cases.
GAZELLOSPIRA TORTICORNIS ( AYMARD , 1854 ) FROM THE LATE PLIOCENE LOCALITY OF SÉSKLO ( THESSALY , GREECE )

The locality of Sésklo (E. Thessaly, Greece) has yielded an interesting fossil fauna of Late Pliocene age (MNQ17). The Bovids are the most frequent elements, comprising mainly the genera Gazella and Gazellospira. The sample of Gazellospira torticornis is described in this study. Its morphology and dimensions are typical, showing no considerable differences in comparison to the Western European samples.
Synthesis and Characterization of Amorphous Calcium Phosphate Nanoparticles

The synthesis and characterization of amorphous calcium phosphate (ACP) nanoparticles were reported in this work. We show that relatively monodisperse ACP nanoparticles with a size of sub-100 nm can be prepared by a hydrothermal reaction of calcium chloride (CaCl2) and disodium adenosine triphosphate (Na2ATP) in the presence of sodium phytate as an additive. Their compositions and structures were confirmed using a series of material characterization techniques. Our results exhibit that ACP nanoparticles synthesized using sodium phytate enhanced the stability of maintaining their amorphous nature and prevented from a conversion to crystalline hydroxyapatite (HAP). ACP nanoparticles with the improved stability have potential uses in biomaterial applications in regenerative medicine.
MOLECULAR EXPRESSION OF CYCLIN DEPENDENT KINASE INHIBITOR ( p 21 ) IN CANINE TUMORS

p21 is a cyclin dependent kinase inhibitor, that plays an important role in cell growth, differentiation and apoptosis. The aim of present study was to analyze the mutation and expression of tumor suppressor gene (p21) in canine tumors. A total of 26 tumors (mammary tumors and mast cell tumors) and normal samples from different breed of dogs were analyzed by using direct DNA sequencing and quantitative RT-PCR for mutation and expression profiling of p21gene respectively. The coding exon of p21 gene (Exon2 and 3) did not show any polymorphism in studied samples while 69% tumors showed up-regulation of gene. Seventy five percent mammary tumors showed up-regulation of gene with highest fold change 8.69, 7.6, 5.63, 5.21 and 60% mast cell tumor showed up-regulation of gene with highest fold change 7.31. These results indicate that altered expression of tumor suppressor gene may be involved in malignant progression of tumors and might be helpful in the diagnosis and prognosis of canine tumors.
Total phenolic content, antioxidant and antimicrobial activities of extracts from Pistacia lentiscus leaves

The purpose of the current study was to investigate total phenolic (TPC), total flavonoids (TF) and flavonols (FV) contents, as well as antioxidant and antimicrobial activities of different extracts of Pistacia lentiscus leaves. TP compounds were quantified by Folin-Ciocalteu, while antioxidant properties were evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH), radical scavenging assay (RSA), Ferric reducing activity power (FRAP) and β-carotene bleaching (βCB) assay. The antimicrobial activity was assessed against Gram-positive bacteria (Micrococcus luteus, Bacillus subtilis and Listeria innocua), Gram-negative bacteriaum (Escherichia coli) and fungi (Candida pelliculosa and Fusarium oxysporum albidinis). Overall, the ethanol fraction (EEPL) exhibited the highest TPC (70.4 ± 7.07 mg GAE g-1 powder), TF (32.06 ± 1.68 mg QE g-1 powder), FV (14.36 ± 1.68 mg QE g-1 powder) and RSA (IC50 = 5.34 ± 0.2 µg mL-1). Whereas, methanol extract (EMPL) displayed the highest FRAP (1.20 ± 0.02) and dichloromethane extract (EDPL) showed a high βCB (90.32 ± 2.98%). Furthermore, the antioxidant activities of extracts exhibited strong positive correlation with TP, TF and flavonols. The extracts obtained showed good inhibitory effect against most of the bacterial and fungal strains tested, suggesting their possible use as antimicrobial agents in medical or agro-industry sectors.
Canine Pseudopregnancy : A Review

This chapter reviews the most relevant features of the patho-physiology, clinical signs, diagnosis, treatment and prevention of overt, i.e. clinical, pseudopregnancy in dogs. Clinical pseudopregnancy is a syndrome observed in non-pregnant dogs and is characterized by clinical signs such as nesting, weight gain, mammary enlargement and lactation. It typically occurs in nonpregnant bitches about 6 to 12 weeks after estrus. Diagnosis is based on clinical signs. While prolactin has a central role in the symptomology of clinical pseudopregnancy, the precise etiology is not yet completely understood. Some studies suggest that at some point during diestrus (metestrus) the circulating prolactin concentrations rise to higher than normal levels in overtly pseudopregnant bitches compared to those in unaffected bitches in diestrus. It is also possible that individual differences in peripheral sensitivity to prolactin, or even the existence of molecular variants of canine prolactin with different bioactivities, are involved in the variation of the incidence and severity of pseudopregnancy within and among breeds. Exposure to progesterone and subsequent withdrawal of progesterone is apparently involved, based on effects of exogenous progesterone and on the frequent induction of pseudopregnancy by spaying (ovariectomy or ovariohysterectomy) during the luteal phase, i.e., in the metestrus (diestrus) stage of the cycle. Considering that overt pseudopregnancy is usually a selflimiting and possibly a quasi-physiological state, mild cases usually are not presented for treatment or are determined to need no treatment. However, physical as well as behavioral changes can be so extensive as to be intolerable for owners, and treatment is typically sought late in the course of the syndrome. The reported relation between a history of overt pseudopregnancy and subsequent mammary tumor development suggests that treatment may be more important than previously assumed. Sex steroids and in particular progestins traditionally used to treat pseudopregnancy have side effects which outweigh any benefits, although androgens like mibolerone may be useful where available. Inhibition of prolactin release by administration of an ergot derivative such as bromocriptine, cabergoline or metergoline has proven to be highly effective for the treatment of canine pseudopregnancy, and more appropriate than the use of steroids. Although some of these ergot derivatives can present some untoward side effects, such effects are typically transient and can usually be tolerated or managed. Predisposed bitches not intended for breeding should be spayed because ovariectomy is the only permanent preventive measure.
Diabetogenicity of Pregnancy: Roles of Pancreatic Insulin Hypersecretion and Peripheral Insulin Insensitivity

In the pregnant state, the maternal metabolism must be reordered to meet the fetal requirements due to the rapid growth and development of the fetus. As emphasized by Freinkel, the graft of the conceptus on the maternal organism represents a new site for hormone biosynthesis and metabolism, and modifies maternal fuel economy. It is well known in fact that during pregnancy, despite a dramatic increase in insulin secretion, insulin effectiveness is diminished in maternal tissues. This antagonist effect of pregnancy on insulin action is more notable when the mother is fasting. The diminished ability of insulin action to promote glucose uptake is coupled with heightened lipolysis, resulting in increased availability of free fatty acids. This phenomenon called by Freinkel "accelerated starvation" may be explained with a teleologic approach as a mechanism provided to divert the maternal fuel economy toward increasing utilization of fat to make glucose available for the fetoplacental unit. Although it is well appreciated that the hormonal changes induced by the pregnant sate and the removal of substrates by the conceptus are the two main driving forces of accelerated starvation, the sequence of events leading to the reassessment of the metabolic status has not been fully elucidated. It is unclear, for example, what time in gestation insulin hypersecretion is initiated. Moreover, it is not known to what extent such insulin hypersecretion is a secondary response to insulin resistance, or is a primary response to pregnancy that precedes the appearance of insulin resistance.
An exploration of the practices of nurse prescribers who care for people with diabetes: a case study

Aim. To explore the practices of nurse prescribers who care for people with diabetes. Background. The use of medicines is an important component of the care of patients with diabetes. However, education and support is equally important to the successful management of this group. These are areas of care in which nurses have traditionally been involved. Evidence suggests that combining nursing skills with prescribing may result in shared decision-making and increased medicines concordance. Design and methods. A collective case study of nine practice settings across England in which nurses prescribed medicines for people with diabetes. Data comprised of semi structured interviews (n = 31), patient questionnaires (n = 131) and video-taped observations of nurse consultations (n = 35). Data analysis included thematic analysis and descriptive statistics. Data were collected between October 2007–September 2008. Results. Nurses demonstrated good communication skills, which they integrated with the ability to prescribe. Questionnaire and video data confirmed an exchange of information between nurse and patient about aspects of self-care and medicines management. Additional benefits included improved efficiency, supported by patient satisfaction with access and waiting times. Nurses were inconsistent in explaining the risks and benefits of treatments and side-effects and exploring the use of non-prescribed herbal or over-the-counter medicine. Conclusion. The care nurses are able to provide to people with diabetes is optimised through prescribing. Further evidence is required to evaluate nurse prescribing from the patient’s perspective. Our findings will be of interest to those keen to develop the prescribing role for nurses involved in diabetes service delivery. Relevance to clinical practice. Prescribing is a valuable development through which nurses are able to encourage self-care and work towards shared-decision making with patients in a way that supports national guidance on the care of people with diabetes.
Biological and chemo-pathological comparative study on the effect of insulin and lettuce oil on experimentally-induced diabetic rats

Background: There is upward evidence that established the connection between dietary polyunsaturated fatty acids (PUFA) and insulin action and sensitivity . Objective: The main objective is to compare the biological, biochemical and histopathological effects of insulin and lettuce oil (poly unsaturated fatty acids) on alloxan induced diabetic rats. Methods: 42 Albino rats were divided into 6 groups : the first group fed on basal diet ( control negative) . Rats in the other five groups were all injected subcutaneously with 150 mg/kg body weight of alloxan to induce hyperglycemia then those rats were subdivided into the followings: a group that remained as induced diabetic ‘control positive’ [2 nd group] , a group that fed on basal diet and subcutaneously injected with insulin 1 IU /kg body weight twice weekly [3 rd group] ; a group that fed on basal diet + injected with half of the insulin dose mentioned in the previous group + dietary supplemented with Lettuce oil 2% (LO2%) [4 th group]; a group that fed on basal diet + dietary supplemented with Lettuce oil 4% (LO4%) [5 th group], and the 6 th group was fed on basal diet + dietary supplemented with Lettuce oil 6% (LO6%). At the end of the experimental period (8 weeks), different biological and serological parameters were estimated and specimens from the pancreas, liver and kidney were collected for histopathological examination. Results : Diabetic rats either treated with insulin alone or combined with LO2% showed significant increase in the food efficiency ratio (FER) with marked decrease in food intake (FI) . Rats in the all the intervention groups elicited variable degrees of decline in the serum glucose level . Insulin treated ,insulin +LO2% , LO4% and LO6% groups showed significant decrease in the serum triglycerides , LDL and VLDL and elicited significant increase in serum HDL. Addition of LO2% to the diet of diabetic rats in combination with insulin injection displayed significant decrease in the urea nitrogen and creatinine and by increasing the amount of lettuce oil added to the diabetic rat diets , the mean values of uric acid & urea nitrogen and creatinine levels were directed toward the control negative values. Serum aspartate amino transferase (AST) level was significantly decreased in the groups treated either with insulin only or fed on LO4% & LO6%. Histopathological results showed that, the combination between insulin therapy and dietary supplementation with lettuce oil descend the curve representing tissue damage and histopathological lesions resulted from diabetes in the liver, kidney and pancreatic tissues. Conclusion: The study recommended the beneficial dietary supplementation of lettuce oil in combination with insulin therapy in dealing with diabetes to decline the consequent diabetic complications .
Exploring the Effects of Head Injuries Among Battered Women

Abstract This qualitative study examined the link between chronic woman battering and head injuries in a sample of 52 battered women. The voices of the women in terms of the qualitative data revealed that severe and repeated women battering seems to be associated with head injuries, flashbacks, insomnia, major depression and nightmares of the batterer killing the victim. The research findings support the need for neurological workups among battered women with severe head injuries to rule out temporal lobe epilepsy, and other traumatic brain injuries. It is imperative that battered women be assessed and screened for neurological injuries as well as mental disorders so that appropriate medical and mental health services can be provided. Social workers and psychiatric nurses in hospital emergency rooms and other medical settings are in a pivotal role to detect and facilitate intervention for battered women with neurological injuries and mental disorders.
4047 Review of Antibiotic Pollution . . . Distribution of Antibiotics in Chinese Watersheds

China consumes 0.15-0.2 million tons of antibiotics yearly, which takes up 50% of the world’s consumption. In this paper, 7 watersheds in China were investigated in order to show a clear picture of the antibiotic distribution in the environment, seasonal variation, and sources. We find that the majority of the aquatic antibiotics come from livestock and aquaculture, followed by medical waste, wastewater treatment plants, and domestic sewage. The spatial distribution of antibiotics varies greatly. Antibiotic concentrations were the lowest in the Yangtze River while the highest was in the Liaohe River and the Pearl River. Songhua watershed and the Southwest River, influenced by the economy and population in the northwest region, displayed a lower quantity of antibiotics. Seasonal variance showed dry season concentrations that were higher than the wet season. Additionally, antibiotics exist not only in the water but also in the sediments. Overall, the distribution of antibiotics in China is uneven due to the economy and population levels. Public health risk and ecological impacts are big concerns regarding the great deal of antibiotic consumption and discharge.
Viral vs bacterial community-acquired pneumonia: Radiologic features

Background: Radiologic findings in the viral community-acquired pneumonia (CAP) are poorly characterized. Aims and objectives: To describe and compare the radiologic findings of patients with bacterial (BP) vs those with viral pneumonia (VP). Methods: Adults with CAP admitted for at least 24h in a 500-bed acute care hospital from November 2009 to October 2010 were included. Diagnostic methods were blood and sputum cultures, antigen urinary detection, sputum analysis by polimerase chain reaction for 4 respiratory bacteria and 15 respiratory viruses. Initial chest radiographs (CR) were reviewed by a team of radiologists. We defined consolidation as not well-defined opacities with aerial bronchogram, multifocal distribution as more than 1 separated areas affected and diffuse distribution as >60% of the parenchyma affected. Results: 125 patients with CAP were included. 43 (34.4%) were BP, 23 (18.4%) VP and 21 (16.8%) co infection (BP and VP). 40.3% of patients had bilateral infiltrates. Consolidation pattern was seen in 90.3%; the rest presented with interstitial affectation. 47.2% presented multifocal distribution, 43.4% focal distribution and 9.4% diffuse distribution. Pleural effusion was seen in 14.1%. No statistical significant differences were found in the comparison of the CR according to the etiology (BP vs VP). Conclusions: Viral CAP presented frequently with a consolidation in the initial CR. Unilateral, multifocal and consolidation pattern without pleural effusion was the most frequent radiologic finding. CR is not a good tool to discriminate between BP and VP.
Influence of relational bonding , trust and satisfaction on customer commitment and loyalty to Bank Jatim

Article Type: Full Length Research Article This study was aimed at examining the effect of relational bonding, trust and satisfaction on customer commitment and loyalty to Bank Jatim. Competition in the banking industry is very sharp nowadays, therefore Bank Jatim requires their management to improve performance to sustain and develop relationship marketing in other to always provide the best services. This is to ensure that customer confidence is maintained, permanent bonding of a long-term relationship in harmony is achieved; and still customer satisfaction is retained; in other for customers to remain committed always and be loyal to Bank Jatim. The population in this study are all customers of Bank Jatim, who bank in all branch offices in East Java, and uses banking services such as savings, checking and credit. The population is infinite because it is dificult to be certain of the number of customers Bank Jatim has. Based on accidental sampling, 240 respondents were used in this study. Structural equation modelling (SEM) was used to analyze the data; using analysis of moment structure (AMOS) series 5. It was observed that relational bonding, trust and satisfaction had significant effects on customer commitment. But relational bonding, trust, satisfaction, and commitment had no significant effect on customer loyalty. ©2016 BluePen Journals Ltd. All rights reserved