Miracle-dz/UniFAR-FTUs huggingface dataset:
The Impact of Human Immunodeficiency Virus Serostatus on Reproductive Decisions of Women

Each year in the United States, several thousand women infected with the human immunodeficiency virus (HIV) become pregnant. The scope of the pediatric HIV epidemic will be determined by the reproductive decisions of these women. Although initial studies have not documented an effect of serostatus on reproductive choice, these studies have been limited to single-risk groups (eg, drug users) and have had small numbers of participants. We studied 108 HIV-seronegative women and 98 seropositive women through an index pregnancy and for an average of 1.5 years postpartum. Thirty-four of the seronegative women (31%) and 32 of the seropositive women (33%) learned their serostatus early enough in pregnancy to have the option to undergo abortion. One of the 34 seronegative women (2.9%) and six of the 32 seropositive women (18.8%) chose abortion (P < .05). During follow-up, we found no significant differences in the numbers of pregnancies or live births between seropositive and seronegative women, or between drug-using and non-drug-using women. Among those who developed AIDS (N = 10), no live births occurred during follow-up. Although positive HIV status did correlate with the decision to terminate pregnancies, it did not correlate with subsequent fertility.
Fractures of the Olecranon: A 15- to 25-Year Followup of 73 Patients

The incidence of olecranon fractures in adults and the long-term outcome of closed olecranon fractures in 45 women and 28 men (mean age, 54 and 36 years at the time of fracture, respectively), were examined at a mean of 19 years after the fracture. The uninjured elbows served as controls. Thirteen percent of the original fractures were displaced less than 2 mm, 65% more than 2 mm, and 22% were multifragmental. Primary treatment consisted of mobilization in 4%, application of a plaster cast in 12%, and open reduction and internal fixation in 84% of the elbows. The incidence of an isolated fracture of the olecranon in individuals older than 16 years was 1.15 per 10,000 person-years. Eighty-four percent of the 73 patients had no complaints at followup, 12% had occasional pain, and 4% had daily pain. Ninety-six percent had an excellent or good outcome. Elbow flexion and extension were reduced but most patients had no or only occasional subjective complaints. Radiographic signs of degenerative changes were found in more than 50% of the formerly fractured elbows, which was more than in the uninjured (11%). Radiographic signs of osteoarthritis were found in 6% of the formerly fractured elbows versus zero percent in the uninjured, of which only two patients had a poor outcome. Isolated, closed fractures of the olecranon in adults have a favorable, long-term outcome.
Muscarine reduces inwardly rectifying potassium conductance in rat nucleus accumbens neurones.

1. Intracellular recordings were made from neurones in the nucleus accumbens in slices from the rat brain maintained in vitro. 2. Muscarine (1‐100 microM) depolarized 101 of 107 neurones; this was associated with an increase in the input resistance. The potential change reversed polarity with conditioning hyperpolarization and the reversal potential was linearly related to the logarithm of the extracellular potassium concentration. 3. The depolarization caused by muscarine was not changed by tetrodotoxin (1 microM) or by a solution that contained lower levels of calcium (0.24 instead of 2.4 mM), higher levels of magnesium (5 instead of 1.2 mM) and cobalt (2 mM). 4. Muscarine caused an inward current and a decrease in slope conductance when applied to neurones voltage clamped near their resting potential (‐82 mV). The current caused by muscarine reversed polarity at the potassium equilibrium potential. The current‐voltage relation of the neurones between ‐60 and ‐120 mV was well fitted by assuming a voltage‐independent potassium conductance and an inward rectifier potassium conductance; muscarine reduced predominantly the inward rectifier conductance. 5. Phorbol‐12,13‐diacetate (3 microM) and 5‐hydroxytryptamine mimicked the action of muscarine. The inward currents caused by muscarine or 5‐hydroxytryptamine were occluded by the inward current evoked by the phorbol ester. 6. The depolarization caused by muscarine was competitively antagonized by pirenzepine; the dissociation constant of 11 nM suggested involvement of the M1 receptor. 7. It is concluded that muscarine acts at M1 receptors to reduce the membrane potassium conductance and that activation of protein kinase C may be an intermediate step.
Targeting angiogenesis inhibits tumor infiltration and expression of the pro‐invasive protein SPARC

The solid growth of high‐grade glioma appears to be cri‐tically dependent on tumor angiogenesis. It remains unknown, however, whether the diffuse infiltration of glioma cells into healthy adjacent tissue is also dependent on the formation of new tumor vessels. Here, we analyze the relationship between tumor angiogenesis and tumor cell infiltration in an experimental glioma model. C6 cells were implanted into the dorsal skinfold chamber of nude mice, and tumor angiogenesis was monitored by intravital fluorescence videomicroscopy. Glioma infiltration was assessed by the extent of tumor cell invasion into the adjacent chamber tissue and by expression of SPARC, a cellular marker of glioma invasiveness. To test the hypothesis that glioma angiogenesis and glioma infiltration are codependent, we assessed tumor infiltration in both the presence and the absence of the angiogenesis inhibitor SU5416. SU5416 is a selective inhibitor of the VEGF/Flk‐1 signal‐transduction pathway, a critical pathway implicated in angiogenesis. Control tumors demonstrated both high angiogenic activity and tumor cell invasion accompanied by strong expression of SPARC in invading tumor cells at the tumor–host tissue border. SU5416‐treated tumors demonstrated reduced vascular density and vascular surface in the tumor periphery accompanied by marked inhibition of glioma invasion and decreased SPARC expression. A direct effect of SU5416 on glioma cell motility and invasiveness was excluded by in vitro migration and invasion assays. These results suggest a crucial role for glioma‐induced angiogenesis as a prerequisite for diffuse tumor invasion and a possible therapeutic role for anti‐angiogenic compounds as inhibitors of both solid and diffuse infiltrative tumor growth. Int. J. Cancer 87:261–268, 2000. © 2000 Wiley‐Liss, Inc.
Why the Pap test? Awareness and use of the Pap test among women in the United States.

OBJECTIVE To inform campaign development by assessing awareness, previous receipt, and knowledge of the purpose of Papanicolaou (Pap) testing among women aged ≥ 18 years and to identify differences in awareness, receipt, and knowledge by demographic characteristics. METHODS Data were analyzed from the 2008 HealthStyles survey, an annual mail survey conducted in the United States covering trends in health-related behavior. Women were asked questions on awareness, past use, and knowledge of the purpose of the Pap test and other gynecologic tests and procedures; 2991 women participated. RESULTS Although 96.7% of the women had heard of and 93.0% reported having received a Pap test, these proportions were lower among those who were 18-34 years old and among those who had lower levels of education and income. Over 80% knew the Pap test was used to screen for cervical cancer, but 63.3% believed it also was used to screen for vaginal cancer (44.9%), sexually transmitted diseases (STDs) other than human papillomavirus (HPV) (41.7%), ovarian cancer (40.6%), and other cancers and infections. CONCLUSIONS General familiarity and past receipt of the Pap test were high, but misconceptions about its purpose were prevalent. It is important that women understand what a routine Pap test is and is not capable of detecting so that signs and symptoms of gynecologic conditions other than cervical cancer may be recognized and addressed appropriately.
Testosterone deficiency is associated with increased risk of mortality and testosterone replacement improves survival in men with type 2 diabetes.

OBJECTIVE Men with type 2 diabetes are known to have a high prevalence of testosterone deficiency. No long-term data are available regarding testosterone and mortality in men with type 2 diabetes or any effect of testosterone replacement therapy (TRT). We report a 6-year follow-up study to examine the effect of baseline testosterone and TRT on all-cause mortality in men with type 2 diabetes and low testosterone. RESEARCH DESIGN AND METHODS A total of 581 men with type 2 diabetes who had testosterone levels performed between 2002 and 2005 were followed up for a mean period of 5.81.3 S.D. years. mortality rates were compared between total testosterone 10.4nmol/l (300ng/dl; n=343) and testosterone 10.4nmol/l (n=238). the effect of TRT (as per normal clinical practise: 85.9% testosterone gel and 14.1% intramuscular testosterone undecanoate) was assessed retrospectively within the low testosterone group. RESULTS Mortality was increased in the low testosterone group (17.2%) compared with the normal testosterone group (9%; P=0.003) when controlled for covariates. In the Cox regression model, multivariate-adjusted hazard ratio (HR) for decreased survival was 2.02 (P=0.009, 95% CI 1.2-3.4). TRT (mean duration 41.6±20.7 months; n=64) was associated with a reduced mortality of 8.4% compared with 19.2% (P=0.002) in the untreated group (n=174). The multivariate-adjusted HR for decreased survival in the untreated group was 2.3 (95% CI 1.3-3.9, P=0.004). CONCLUSIONS Low testosterone levels predict an increase in all-cause mortality during long-term follow-up. Testosterone replacement may improve survival in hypogonadal men with type 2 diabetes.
Virus Infection Triggers SUMOylation of IRF3 and IRF7, Leading to the Negative Regulation of Type I Interferon Gene Expression*

Viral infection activates Toll-like receptor and RIG-I (retinoic acid-inducible gene I) signaling pathways, leading to phosphorylation of IRF3 (interferon regulatory factor 3) and IRF7 and stimulation of type I interferon (IFN) transcription, a process important for innate immunity. We show that upon vesicular stomatitis virus infection, IRF3 and IRF7 are modified not only by phosphorylation but by the small ubiquitin-related modifiers SUMO1, SUMO2, and SUMO3. SUMOylation of IRF3 and IRF7 was dependent on the activation of Toll-like receptor and RIG-I pathways but not on the IFN-stimulated pathway. However, SUMOylation of IRF3 and IRF7 was not dependent on their phosphorylation, and vice versa. We identified Lys152 of IRF3 and Lys406 of IRF7 to be their sole small ubiquitin-related modifier (SUMO) conjugation site. IRF3 and IRF7 mutants defective in SUMOylation led to higher levels of IFN mRNA induction after viral infection, relative to the wild type IRFs, indicating a negative role for SUMOylation in IFN transcription. Together, SUMO modification is an integral part of IRF3 and IRF7 activity that contributes to postactivation attenuation of IFN production.
Lottery Coexistence on Rocky Shores: Weak Niche Differentiation or Equal Competitors Engaged in Neutral Dynamics?

Reconciling how niche and neutral processes may be important in species coexistence has revealed two important weaknesses in our collective understanding of species diversity: few empirical studies have determined whether species are truly coexisting, and fewer still have properly evaluated whether coexistence is achieved through niche differentiation or ecological equivalence. Here, we ask whether two common barnacles, Jehlius cirratus and Notochthamalus scabrosus, coexist locally and whether the slight but persistent differences in their distribution provide sufficient fitness trade-offs to overcome differences in competition. Both species recovered after experimental reduction; that is, they coexist, with no indication of hierarchical exclusion. No fitness inequalities affected species performance or interference effects on vital rates at any shore level, indicating no trade-offs in intra-interspecific effects across the ecological gradient. Additionally, no relationship was found between per capita population growth rates of either species with its own relative abundance; that is, neither species has a demographic advantage when rare. Instead, a lottery for space during settlement largely determines species’ distributions, evidenced by the positive correlation across sites and tidal elevations between the relative abundances of adults and the recruits of the prior season. We conclude that Jehlius and Notochthamalus coexist neutrally, or nearly so, but discuss whether small, nonsignificant, and probably ephemeral fitness differences, which are inconsistent across the tidal gradient, could provide enough niche differentiation to promote coexistence.
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Conventional wideband receivers achieve large imageand harmonic-rejection ratios (IRR and HRR) by using off-chip high selectivity discrete LC filters that track the frequency of the desired channel [1]. They usually require manual frequency alignment and a large number of external components, resulting in increased cost and a large board area. One solution to eliminate the front-end tracking filters is to use an up-downconversion architecture in which the desired channel is first upconverted to a fixed out-of-band intermediate frequency where a sharp roll-off SAW filter is used to attenuate the blocker channels [2]. In this architecture, both the image and the LO harmonics are moved out of the receiver band. Its main drawbacks are high complexity (two PLLs and two IF chains), large power dissipation, and the use of an expensive RF SAW filter. Fully integrated tuners have been realized for cable TV applications [3] that have relaxed IRR and HRR specifications (50dB). This paper presents a front-end mixer that achieves IRR/HRR in excess of 65/73dB and thus allows for full-integration of a terrestrial TV tuner with no need of off-chip selective filters.
Phenolics and antioxidant capacity of table grape (Vitis vinifera L.) cultivars grown in Chile.

UNLABELLED Grapes (Vitis vinifera L.) possess health-promoting effects attributed to their supply of a wide variety of bioactive phenolics. Juice and skin fractions of 4 varieties of table grapes: Red Globe, Crimson Seedless, Autumn Royal, and Ribier were prepared to determine and compare their total phenolics content, antioxidant capacity (DPPH, FRAP, and ORAC), anthocyanins, and specific phenolics (caffeic acid, gallic acid, resveratrol, and catechin) content, since a series of positive health benefits are expected from the intake of any of these fractions. Higher amounts of total phenolics and antioxidant capacity were observed in the skin fractions (P < 0.05). Blue grapes (Autumn Royal and Ribier) exhibited higher phenolics content and antioxidant capacity (P < 0.05) than red grapes. The most abundant phenolic compound observed was catechin (P < 0.05). Significant correlations between the antioxidant capacity and total phenolics were observed in grape juice and skin fractions. Autumn Royal juice provides a very high amount of phenolics, anthocyanins, and exhibits the highest antioxidant capacity, offering the best health promoting properties compared with the other grape varieties studied. PRACTICAL APPLICATION Grapes possess health-promoting effects attributed to their supply of a wide variety of bioactive phenolics. Grape juice made with blue grapes (Autumn Royal, Ribier) exhibit higher phenolics content and antioxidant capacity than juice elaborated with red grapes (Red Globe, Crimson Seedless). The skin is a good source of phenolics and has a high antioxidant capacity. Specific health-promoting phenolics are more abundant in blue grapes, mainly in their skin fraction, which should not be discarded.
Comparative chemical composition and in vitro antioxidant activities of essential oil isolated from the leaves of Cinnamomum tamala and Pimenta dioica

Cinnamomum tamala Nees and Eberm (tejpat) and Pimenta dioica (L.) Merr (pimento) leaves are commonly used for flavouring food and widely used in pharmaceutical preparations because of their hypoglycemic, carminative and stimulant properties. In this study, we compared the chemical composition and antioxidant activities of tejpat and pimento essential oils by employing various in vitro methods. GC and GC-MS analyses were done to find out the chemical composition, and the main constituent identified in tejpat and pimento leaf oils was eugenol. Both the oils showed significant radical scavenging activity against DPPH and superoxide radicals with a potent metal chelating activity and were compared with that of standard compound, eugenol. Among the two oils, tejpat oil showed better activity in terms of antioxidative potential.
Topology of gap junction networks in C. elegans.

Gap junctions are prevalent in every nervous system, but their role in information processing remains largely unknown. In C. elegans, the role of gap junctional communication in touch sensitivity has been demonstrated. In this animal, the entire complement of gap junctions in the nervous system is documented, therefore providing a good model for the computational investigation of circuit functions of gap junctions.We explored several hypotheses about the role of gap junctions in the nervous system of C. elegans by systematically analysing an anatomical database with recursive algorithms. We find that gap junctions connect different sets of neurons from those connected by chemical synapses. In addition, when analysing the topology of the gap-junction networks, we find that, surprisingly, most (92%) neurons in the worm are linked in a single gap-junction network. The worm nervous system can only be divided into smaller networks by assuming that two or more gap junctions are necessary for functional coupling or that neural activity has limited propagation. However, these groups, and others identified using algorithms with subsets or combinations of restrictive criteria, do not correspond to any known circuits identified in genetic and behavioral studies. Finally, we notice that the function of some gap junctions appears linked to their precise location on the neuronal processes. We propose that the location of the gap junctions within the neuron determines their functional role.
Stability of liquid sheet edges

Accelerating edges of thin liquid sheets are ubiquitous and are known to experience a longitudinal (along-the-edge) instability, which often leads to their break-up and atomization. The fundamental physical mechanisms of this instability are studied analytically in the quasisteady regime, which admits a concise modeling. It is discovered that the classical Rayleigh–Taylor mechanism is substantially modified which leads to a stability picture different from that for flat interfaces, in part due to an interplay with Rayleigh–Plateau mechanisms. In particular, as the Bond number increases, first, only one critical wavenumber is excited, but for higher values of the Bond number several critical wavenumbers can coexist with the same growth rates. This allows for the transition from the regular picture, in which one wavelength sets the pattern, to the frustrated picture, in which a few wavenumbers compete with each other.
Dynamic Factual Summaries for Entity Cards

Entity cards are being used frequently in modern web search engines to offer a concise overview of an entity directly on the results page. These cards are composed of various elements, one of them being the entity summary: a selection of facts describing the entity from an underlying knowledge base. These summaries, while presenting a synopsis of the entity, can also directly address users' information needs. In this paper, we make the first effort towards generating and evaluating such factual summaries. We introduce and address the novel problem of dynamic entity summarization for entity cards, and break it down to two specific subtasks: fact ranking and summary generation. We perform an extensive evaluation of our method using crowdsourcing. Our results show the effectiveness of our fact ranking approach and validate that users prefer dynamic summaries over static ones.
Inhibins are the major activin ligands expressed during early thymocyte development

Activins are members of the transforming growth factor‐beta (TGFβ) superfamily, which regulate cell differentiation processes. Here we report the first quantitative analysis of the expression of Activin/Inhibin ligands, type I and II receptors, as well as Smad proteins in fetal (E14–E16) and adult thymic subpopulations. Our data showed that Alk4, ActRIIA, ActRIIB, and Smads 2, 3, and 4, are expressed in fetal thymus (E14 > E15 > E16) and in thymocytes from adult mice (mostly in the double negative [DN] subpopulation). Ligand expression analysis showed that βA, βB, and α subunits were mainly detected in thymic stromal cells. Interestingly, α subunits were expressed at much higher levels compared to βA and βB subunits, demonstrating for the first time the potential role of Inhibins as important mediators during early T cell development. Our data indicate that Activin/Inhibin signaling could regulate the process of thymus organogenesis and early thymocyte differentiation, as it has been demonstrated for other members of the TGF‐β superfamily. Developmental Dynamics 235:1124–1132, 2006. © 2006 Wiley‐Liss, Inc.
Melatonin attenuates methamphetamine‐induced disturbances in mitochondrial dynamics and degeneration in neuroblastoma SH‐SY5Y cells

Methamphetamine (METH) is a psychostimulant drug that can cause toxicity and degeneration in the brain. The toxicity due to METH involves multiple pathways, including the mitochondrial‐dependent death pathway. Several pieces of evidence have emphasized that the fragmentation of mitochondria into smaller structures plays some role in the cell‐death process. In this study, we investigated the role of mitochondrial dynamics in METH‐induced toxicity in human dopaminergic neuroblastoma SH‐SY5Y cultured cell lines. In addition, the protective effect of melatonin against METH‐induced toxicity was investigated. Our results show that METH significantly decreased cell viability and increased the levels of the mitochondrial fission protein, Fis1 and the Drp1 oligomer. However, the levels of the mitochondrial fusion proteins OPA1 and Mfn1 did not change in METH‐treated cells. Melatonin can reverse the toxic effects of the METH‐induced reduction in cell viability and the production of the Fis1 protein and the Drp1 oligomer. Moreover, the morphological alteration of mitochondria was investigated in METH‐treated cells in the presence of melatonin using transmission electron microscopy (TEM). At 24 hr after METH exposure, typical cell shrinkage was observed in SH‐SY5Y cells. Mitochondria were fragmented into small globular structures in a large proportion of METH‐treated cells, but tubular networks of mitochondria were present in large proportions of control‐untreated cells and METH‐treated cells in the presence of melatonin. The results of the present study demonstrate the potential of melatonin to reduce cell death and restore mitochondrial function in neurons affected by METH‐induced toxicity.