Miracle-dz/UniFAR-FTUs huggingface dataset:
Breadth, depth, and speed: diffusion of advertising messages on microblogging sites

Purpose – The purpose of this paper is to present an empirical assessment of the diffusion of advertising messages on microblogging sites. The diffusion properties of advertising messages are quantified based on the following three aspects: diffusion breadth, depth, and speed. Furthermore, this study examines the influence of message- and advertiser-level factors on the diffusion of advertising messages. Design/methodology/approach – The study data comprises 20,000 advertising messages that are randomly drawn from a popular microblogging web site in China. Five message-level factors and four advertiser-level factors are constructed based on the information retrieved from the microblogging web site. Generalized linear modeling is adopted to examine the effects of such factors on the diffusion properties of advertising messages. Findings – The positive driving forces underlying the diffusion of advertising messages on microblogging sites include message length, the advertisers’ in-degrees, and their reputat.
Psychological empowerment and service orientation: A study of front-line employees in the food and beverage industry

ABSTRACT Employees with service orientations can achieve higher service performance and create a competitive advantage for a company. The service process in the food and beverage industry is delivered by front-line employees who wield considerable authority in dealing with customers’ special requests and demands. Psychological empowerment is recognized as employee feelings of empowerment and is able to elevate employees’ self-recognition in the work place, improve efficiency, and increase employee self-respect. This could be an important antecedent of service orientations. This study aimed to explore employees’ demographic characteristics and psychological empowerment as the antecedent factors of service orientations in the food and beverage industry.
Release of C-type natriuretic peptide accounts for the biological activity of endothelium-derived hyperpolarizing factor

Endothelial cells in most vascular beds release a factor that hyperpolarizes the underlying smooth muscle, produces vasodilatation, and plays a fundamental role in the regulation of local blood flow and systemic blood pressure. The identity of this endothelium-derived hyperpolarizing factor (EDHF), which is neither NO nor prostacyclin, remains obscure. Herein, we demonstrate that in mesenteric resistance arteries, release of C-type natriuretic peptide (CNP) accounts for the biological activity of EDHF. Both produce identical smooth muscle hyperpolarizations that are attenuated in the presence of high [K+], the Gi G protein (Gi) inhibitor pertussis toxin, the G protein-gated inwardly rectifying K+ channel inhibitor tertiapin, and a combination of Ba2+ (inwardly rectifying K+ channel blocker) plus ouabain (Na+/K+-ATPase inhibitor). Responses to EDHF and CNP are unaffected by the natriuretic peptide receptor (NPR)-A/B antagonist HS-142-1, but mimicked by the selective NPR-C agonist, cANF4–23. EDHF-dependent relaxation is concomitant with liberation of endothelial CNP; in the presence of the myoendothelial gap-junction inhibitor 18α-glycyrrhetinic acid or after endothelial denudation, CNP release and EDHF responses are profoundly suppressed. These data demonstrate that acetylcholine-evoked release of endothelial CNP activates NPR-C on vascular smooth muscle that via a Gi coupling promotes Ba2+/ouabain-sensitive hyperpolarization. Thus, we have revealed the identity of EDHF and established a pivotal role for endothelial-derived CNP in the regulation of vascular tone and blood flow.
Sex Comparisons for Relative Peak Torque and Electromyographic Mean Frequency During Fatigue

Purpose: This study compared the relative peak torque and normalized electromyographic (EMG) mean frequency (MNF) responses during fatiguing isokinetic muscle actions for men versus women. Method: Twenty men (M age ± SD = 22 ± 2 years) and 20 women (M age ± SD = 22 ± 1 years) performed 50 maximal concentric isokinetic muscle actions of the leg extensors at a velocity of 180°/s while surface EMG signals were detected from the vastus lateralis, rectus femoris, and vastus medialis. The dependent variables were initial, final, and average peak torque; percent decline; the estimated percentage of fast-twitch fibers for the vastus lateralis; and the linear slope coefficients and y-intercepts for normalized EMG MNF versus repetition number. The data were analyzed with independent-samples t tests and 2-way mixed-factorial analyses of variance. Results: The mean initial, final, and average peak torque values for men were greater than those for women. There were no mean differences for percent decline and the estimated percentage of fast-twitch fibers for the vastus lateralis. There were also no sex differences for the linear slope coefficients, but there were differences among the muscles (vastus medialis>vastus lateralis>rectus femoris). The mean y-intercept for the vastus lateralis for men was greater than that for women. Conclusions: Men demonstrated greater peak torque values than those for women, but the declines in peak torque and normalized EMG MNF were similar between the sexes. The vastus medialis was more fatigue-resistant than both the vastus lateralis and rectus femoris.
Effectiveness and Safety of Lower Doses of Mifepristone Combined With Misoprostol for the Termination of Ultra-Early Pregnancy

This study aimed to investigate the effectiveness and safety of lower doses of mifepristone combined with misoprostol for the termination of ultra-early pregnancy. A total of 2500 women with ultra-early pregnancy (amenorrhea ≤ 35 days) were randomly divided into 5 groups with gradually decreased dose of oral mifepristone from 150 to 50 mg followed by 200 µg of oral misoprostol 24 hours later. The primary end point was complete abortion without surgical intervention. Secondary end points were vaginal bleeding, return of menses, and side effects. Rates of complete abortion were high in all groups. Moreover, the lower doses of mifepristone led to shorter vaginal bleeding period, the return of menses on the expected date, and fewer side effects. Lower doses of mifepristone combined with 200 µg of misoprostol are as effective and safe as higher doses of this combination for the termination of ultra-early pregnancy with lower possibility of vaginal bleeding and side effects.
Guest-Defined Hotel Service Quality and Its Impacts on Guest Loyalty

ABSTRACT Quality of service is more difficult to define, measure, and manage than manufacturing products due to the unique characteristics of services. This study explores the dimensions of service quality in the hotel industry, using the Free-listing method, and its impacts on guest satisfaction, word-of-mouth communication, and revisit intention. To accomplish this task, 600 questionnaires were delivered to guests in three-star to five-star hotels in Beijing by five undergraduate students; 430 valid responses were collected. Three satisfiers and seven dissatisfiers for hotel services were identified, and a Hotel Guest Loyalty Model was also identified with ideal goodness-of-fit indices. Further, significant differences in satisfaction and word-of-mouth between Chinese and Western hotel guests were identified, indicating that Westerners were more satisfied with service quality than do Chinese guests, and Westerners showed a higher word-of-mouth intent than do Chinese guests, which is against previous findings by other researchers.
Regulation of RhoA by STAT3 coordinates glial scar formation

Understanding how the transcription factor signal transducer and activator of transcription–3 (STAT3) controls glial scar formation may have important clinical implications. We show that astrocytic STAT3 is associated with greater amounts of secreted MMP2, a crucial protease in scar formation. Moreover, we report that STAT3 inhibits the small GTPase RhoA and thereby controls actomyosin tonus, adhesion turnover, and migration of reactive astrocytes, as well as corralling of leukocytes in vitro. The inhibition of RhoA by STAT3 involves ezrin, the phosphorylation of which is reduced in STAT3-CKO astrocytes. Reduction of phosphatase and tensin homologue (PTEN) levels in STAT3-CKO rescues reactive astrocytes dynamics in vitro. By specific targeting of lesion-proximal, reactive astrocytes in Nestin-Cre mice, we show that reduction of PTEN rescues glial scar formation in Nestin-Stat3+/− mice. These findings reveal novel intracellular signaling mechanisms underlying the contribution of reactive astrocyte dynamics to glial scar formation.
Oral phosphate binders in patients with kidney failure.

Hyperphosphatemia, which is nearly universal in kidney failure, is accompanied by low serum levels of vitamin D and hypocalcemia. Without treatment, severe secondary hyperparathyroidism occurs, which may result in painful fractures, brown tumors, and generalized osteopenia. This article reviews the rationale for treatment with oral phosphate binders, discusses evidence supporting the use of available agents, and suggests an approach for clinical practice.
Responsiveness to HY Antigen Ir Gene Complementation and Target Cell Specificity

The H-2 restricted nature of the cytotoxic T cell responses to the HY antigen in mice has been reviewed, together with mapping data for the H-2 K and/or D association of responses to male cells of the following haplotypes: H-2b, H-2d, H-2k, H-2s. Ir gene complementation is implicated in the HY response of a number of F1 mice derived from non-responder parental haplotypes, and in one recombinant strain. Thus, at least two and possibly more Ir genes are involved in the anti-HY response, in addition to the K and/or D gene products with which HY is obligatorily associated, certainly at the target cell level.
Secure Hash Algorithm based on Efficient Chaotic Neural Network

Secure Hash Algorithm (SHA) is the most popular standard of Cryptographic Hash functions. Several security protocols use SHA to provide message integrity, authentication and digital signature. Nowadays, a new technology based on Chaotic Neural Networks is used to design Hash functions due to the following important properties of Chaos and Neural Networks: non-linearity, compression, confusion and diffusion. Compared to existing Hash functions based on Chaotic Neural Networks, the proposed structure integrates a strong Chaotic generator into neurons instead of using simple Chaotic maps. In fact, simple chaotic maps are not very robust, even against some statistical attacks (Uniformity and NIST). To also reduce the complexity of hash function proposed in ICITST conference (2015), while maintaining strength, we present in this paper a new structure of Hash function. The theoretical analysis and the obtained experimental performances demonstrate the efficiency o f the implemented structure in terms of strong Collision Resistance and High Message Sensitivity compared to SHA-2 and some Chaos-based Hash functions.
Evaluation of Helicobacter pylori in reflux oesophagitis and Barrett's oesophagus.

BACKGROUND: One of the major pathophysiological abnormalities in patients with gastro-oesophageal reflux disease is thought to involve transient lower oesophageal sphincter (LOS) relaxations. One component of the neural mechanism controlling the LOS appears to be a reflex are whose afferent limb originates in the gastric fundus. As inflammation is known to be associated with neural activation an investigation was made to determine whether gastric infection with H pylori is altered in prevalence or distribution in patients with reflux disease. METHODS: Five groups of subjects referred for endoscopy-group 1: 25 controls (asymptomatic individuals with anaemia and normal endoscopy); group 2: 36 subjects with erosive oesophagitis alone (Savary-Millar grades I-III); group 3: 16 subjects with duodenal ulcer alone; group 4: 15 subjects with oesophagitis with duodenal ulcer; group 5: 16 subjects with Barrett's oesophagus. No patients were receiving acid suppressants or antibiotics. An antral biopsy specimen was taken for a rapid urease test, and two biopsy specimens were taken from the antrum, fundus, and oesophagus (inflamed and non-inflamed) for histological evidence of inflammation and presence of H pylori using a Giemsa stain. RESULTS: Nine (36%) controls had H pylori. Patients with duodenal ulcer alone had a significantly higher incidence of colonisation by H pylori than other groups (duodenal ulcer 15 (94%); oesophagitis 13 (36%); oesophagitis+duodenal ulcer 6 (40%); Barrett's oesophagus 4 (25%)). H pylori was not more common in oesophagitis. When H pylori colonised the gastric antrum it was usually found in the gastric fundus. There was no difference in anatomical distribution of H pylori in the different patient groups. In Barrett's oesophagus H pylori was found in two of 16 in the metaplastic epithelium. CONCLUSION: H pylori is not more common and its distribution does not differ in those with oesophagitis compared with control subjects, and is therefore unlikely to be aetiologically important in these patients. H pylori, however, can colonise Barrett's epithelium.
Consequences of asymptomatic bacteriuria in women with diabetes mellitus.

BACKGROUND Women with diabetes mellitus (DM) have asymptomatic bacteriuria (ASB) more often than women without DM. It is unknown, however, what the consequences of ASB are in these women. OBJECTIVE To compare women with DM with and without ASB for the development of symptomatic urinary tract infections (UTIs), renal function, and secondary complications of DM during an 18-month follow-up period. METHODS In this multicenter study we monitored women with DM with and without ASB for the development of symptomatic UTIs, renal function, and secondary complications (ie, retinopathy, neuropathy, microvascular, or macrovascular diseases). Data on the first 18-month follow-up period are presented. RESULTS At least 1 uncontaminated urine culture was available from 636 women (258 with type 1 DM and 378 with type 2 DM). The prevalence of ASB at baseline was 26% (21% for those with type 1 DM and 29% for those with type 2 DM). Follow-up results were available for 589 (93%) of the 636 women. Of these 589 women, 115 (20%) (14% with type 1 DM and 23% with type 2 DM) developed a symptomatic UTI. Women with type 2 DM and ASB at baseline had an increased risk of developing a UTI during the 18-month follow-up (19% without ASB vs 34% with ASB, P =.006). In contrast, there was no difference in the incidence of symptomatic UTI between women with type 1 DM and ASB and those without ASB (12% with ASB vs 15% without ASB). However, women with type 1 DM and ASB had a tendency to have a faster decline in renal function than those without ASB (relative increase in serum creatinine level 4.6% vs 1.5%, P = 0.2). CONCLUSION Women with type 2 DM and ASB have an increased risk of developing a symptomatic UTI than those without ASB.
Complementary Roles for CD19 and Bruton’s Tyrosine Kinase in B Lymphocyte Signal Transduction1

CD19 and Bruton’s tyrosine kinase (Btk) may function along common signaling pathways in regulating intrinsic and B cell Ag receptor (BCR)-induced signals. To identify physical and functional interactions between CD19 and Btk, a CD19-negative variant of the A20 B cell line was isolated, and CD19-deficient (CD19−/−) and CD19-overexpressing mice with the X-linked immunodeficient (Xid; Btk) mutation were generated. In A20 cells, Btk physically associated with CD19 following BCR engagement. CD19 and Btk interactions were not required for initial Btk phosphorylation, but CD19 expression maintained Btk in an activated state following BCR engagement. In primary B cells, CD19 signaling also required downstream Btk function since CD19-induced intracellular Ca2+ ([Ca2+]i) responses were modest in Xid B cells. In addition, CD19 overexpression did not normalize the Xid phenotype and most phenotypic and functional hallmarks of CD19 overexpression were not evident in these mice. However, CD19 and Btk also regulate independent signaling pathways since their combined loss had additive inhibitory effects on BCR-induced [Ca2+]i responses and CD19 deficiency induced a severe immunodeficiency in Xid mice. Thus, CD19 expression amplifies or prolongs Btk-mediated signaling, rather than serving as a required agent for Btk activation. Consistent with this, phosphatidylinositol 3-monophosphate kinase and Akt activation were normal in CD19−/− B cells following IgM engagement, although their kinetics of activation was altered. Thus, these biochemical and compound gene dosage studies indicate that Btk activation and [Ca2+]i responses following BCR engagement are regulated through multiple pathways, including a CD19/Src family kinase-dependent pathway that promotes the longevity of Btk signaling.
There Is Differential Loss of Pyramidal Cells from the Human Hippocampus with Survival after Blunt Head Injury

The experimental literature has shown that neurons within sub-fields of the hippocampus possess differential sensitivities to cell loss after different types of insult to the brain. In humans, after blunt head injury, differential neuronal responses between sub-fields of the hippocampus up to 72 hours after injury have been documented. But, in only a small part of the literature have data for alterations in real numbers of neurons been provided. In this study the hypothesis was tested that, after severe blunt head injury in humans, the total number of neurons within a defined volume of brain tissue differed between different sub-fields of the hippocampus and between groups of patients with differing post-traumatic survivals. Stereological methods were used to measure total cross-sectional area of sub-fields of the hippocampus taken at the level of the lateral geniculate nucleus and count numbers of neurons within each of the CA1, CA2, CA3, and CA4 sub-fields of the hippocampus in patients. The patients used in this study were categorized as follows: Group 1 (early) had survived for 1 week or less; Group 2 (late) survived 6 months or longer after fatal severe head injury; and Group 3 (controls) consisted of age-matched patients that had no history of head injury or disease prior to death. There was a significant loss in cross-sectional area in sub-fields CA3 and CA4 at 1 week or less after injury and in sub-field CA1 at 6 months and greater survival. There was no change in CA2. There was loss of neurons from within a predefined volume of brain tissue in sub-fields CA1, CA3, and CA4 one week or less after injury. But there was no loss in CA2. There was continued loss of neurons from sub-fields CA1 and CA4 between 1 week and 6 months and greater survival, but there was no loss of neurons in sub-fields CA2 and CA3 within the same period. These novel data show that after human severe head injury there is first an acute loss (1 week or less survival) of pyramidal neurons in all hippocampal sub-fields except CA2. Second, there is an ongoing loss of neurons in sub-field CA1 and, most notably, in sub-field CA4, in patients surviving for more than 6 months. However, in neither group of patients is there loss of neurons from sub-field CA2.
Residential consumer perspectives of effective peak electricity demand reduction interventions as an approach for low carbon communities.

Internationally, policy makers have been trying to find ways of changing residential electricity use through improved energy efficiency or by means of behaviour change. Drawing on evidence from an Australian project undertaken in a community of approximately 2200 residents, this paper reviews how a combination of interventions have successfully reduced electricity demand levels to below that of pre-intervention levels. Employing a qualitative methodology and using this successful project as the basis of a case study, this research explores the effectiveness of the electricity demand reduction interventions from the perspective of residents from 22 households. By combining and tailoring interventions to the specific needs and motivations of individual householders, this study demonstrates how a multi-pronged and integrated approach can be effective in addressing the multi-faceted challenge of energy efficiency and behaviour change. The experience with this Australian residential community in achieving an ongoing reduction in electricity use is rare and the findings from the research are internationally relevant in informing policy and practice directions for achieving government-set lower carbon emission targets. This research has important implications for addressing issues related to total consumption and peak demand reduction, both financial and environmental, for the benefit of energy providers and consumers.
Unique, Shared, and Redundant Roles for the Arabidopsis SWI/SNF Chromatin Remodeling ATPases BRAHMA and SPLAYED[W][OA]

Chromatin remodeling is emerging as a central mechanism for patterning and differentiation in multicellular eukaryotes. SWI/SNF chromatin remodeling ATPases are conserved in the animal and plant kingdom and regulate transcriptional programs in response to endogenous and exogenous cues. In contrast with their metazoan orthologs, null mutants in two Arabidopsis thaliana SWI/SNF ATPases, BRAHMA (BRM) and SPLAYED (SYD), are viable, facilitating investigation of their role in the organism. Previous analyses revealed that syd and brm null mutants exhibit both similar and distinct developmental defects, yet the functional relationship between the two closely related ATPases is not understood. Another central question is whether these proteins act as general or specific transcriptional regulators. Using global expression studies, double mutant analysis, and protein interaction assays, we find overlapping functions for the two SWI/SNF ATPases. This partial diversification may have allowed expansion of the SWI/SNF ATPase regulatory repertoire, while preserving essential ancestral functions. Moreover, only a small fraction of all genes depends on SYD or BRM for expression, indicating that these SWI/SNF ATPases exhibit remarkable regulatory specificity. Our studies provide a conceptual framework for understanding the role of SWI/SNF chromatin remodeling in regulation of Arabidopsis development.
Informal Science Education for Girls: Careers in Science and Effective Program Elements.

Addressing the need for continued support of after-school and summer science enrichment programs for urban girls and at-risk youth, this paper describes the educational and career paths of a sample of young women who participated in the Women in Natural Sciences (WINS) program during high school. This study also attempts to determine how the program affected the participants’ educational and career choices after graduation in order to provide insight into the role informal science education programs play in increasing the participation of women and minorities in science, math, engineering, and technology-related fields. Findings revealed that almost all of the young women enrolled in a college program after completing high school. Careers in medical or health-related fields, followed by careers in science, emerged as the highestranking career paths. The majority of the sample perceived having staff to talk to, the job skills learned, and having the museum as a safe place to go as having influenced their educational and career decisions. (This paper is a summary of Fadigan & Hammrich, 2004)