Miracle-dz/UniFAR-FTUs huggingface dataset:
The importance of the location of sodium chlorite application in a multipollutant flue gas cleaning system

In this study, removing sulfur dioxide (SO2), nitrogen oxides (NOx), and mercury (Hg) from simulated flue gas was investigated in two laboratory-sized bubbling reactors that simulated an oxidizing reactor (where the NO and Hg0 oxidation reactions are expected to occur) and a wet limestone scrubber, respectively. A sodium chlorite solution was used as the oxidizing agent. The sodium chlorite solution was an effective additive that enhanced the NOx, Hg, and SO2 capture from the flue gas. Furthermore, it was discovered that the location of the sodium chlorite application (before, in, or after the wet scrubber) greatly influences which pollutants are removed and the amount removed. This effect is related to the chemical conditions (pH, absence/presence of particular gases) that are present at different positions throughout the flue gas cleaning system profile. The research results indicated that there is a potential to achieve nearly zero SO2, NOx, and Hg emissions (complete SO2, NO, and Hg removals and ∼90% of NOx absorption from initial values of 1500 ppmv of SO2, 200 ppmv of NOx, and 206 μg/m3 of Hg0) from the flue gas when sodium chlorite was applied before the wet limestone scrubber. However, applying the oxidizer after the wet limestone scrubber was the most effective configuration for Hg and NOx control for extremely low chlorite concentrations (below 0.002 M) and therefore appears to be the best configuration for Hg control or as an additional step in NOx recleaning (after other NOx control facilities). The multipollutant scrubber, into which the chlorite was injected simultaneously with the calcium carbonate slurry, appeared to be the least expensive solution (when consider only capital cost), but exhibited the lowest NOx absorption at ∼50%. The bench-scale test results presented can be used to develop performance predictions for a full- or pilot-scale multipollutant flue gas cleaning system equipped with wet flue gas desulfurization scrubber. Implications The control of NOx, Hg, and SO2 emissions from coal-fired combustors is an important, worldwide concern affecting environmental pollution. In both the European Union and the United States, NOx and SO2 emissions are subject to newly tightened emission limits. This paper investigated the NOx, Hg, and SO2 removals in a flue gas cleaning system equipped with a classical wet limestone scrubber, enhanced by a solution of sodium chlorite. This paper demonstrated that the location at which the sodium chlorite is applied in a flue gas cleaning system affects the control of these pollutants and discusses how possible solutions could be practically implemented.
Physiological Correlates of Painful Stimulation in Preterm Infants

Objective:The study investigates the physiological responses of preterm infants to procedures that are routinely performed in intensive care nurseries. Changes in heart rate, respiration rate, and oxygen saturation were examined as indicators of the level of discomfort experienced by the infants during the procedures. Design:Clinical descriptive. Systematic observations of the infants were conducted during periods of rest as well as during routine interventions. Setting:All observations were recorded from monitored preterm infants in the intensive care units of two urban hospitals. Patients:Thirty-five preterm infants 24–30 weeks gestational age and weighing <2,000 g at birth. Data were collected from all infants in the units who met the weight criterion. Interventions:The researchers observed the infants while the intensive care nursery staff were performing routine care procedures. Observations were made during procedures that adults would consider to be painful, such as injection, heel stick, tape removal, and squeezing of the heel to induce blood flow after heel stick, as well as nonpainful procedures, such as handling, temperature taking, alcohol swabbing, patting, taping a tube, feeding, and placing a pacifier. Main Outcome Measures:Heart rate, respiration rate, and oxygen saturation were recorded from infant monitors. Mean values of the three measures during procedures were compared with mean values before and after procedures. Results:Significant differences (p <0.001) were found among pre-, peri-, and postprocedures for all three outcome measures. Heart rate and respiration rate means were significantly (p < 0.001) higher during procedures that adults consider to be painful than in those regarded as nonpainful. Oxygen saturation was lower (p <0.001) for painful procedures thatn for nonpainful procedures. Gender and infant size comparisons yielded inconclusive results. Conclusion:The outcome measures appear to be reliable indices of preterm infant responses to painful stimulation.
Measuring and Modeling Execution Cost and Risk

Financial markets are considered to be liquid if a large quantity can be traded quickly and with minimal price impact. Although the idea of a liquid market involves both a cost as well as a time component, most measures of execution costs tend to focus on only a single number that reflects average costs and do not explicitly account for the temporal dimension of liquidity. In practice, trading takes time because larger orders are often broken up into smaller transactions or because of price limits. Recent work shows that the time taken to transact introduces a risk component in execution costs. In this setting, the decision can be viewed as a risk–reward trade-off faced by the investor who can solve for a mean-variance utility-maximizing trading strategy. Engle, Ferstenberg, and Russell introduce an econometric method to jointly model the expected cost and risk of the trade, thereby characterizing the mean-variance tradeoffs associated with different trading approaches, given market and order characteristics. They apply their methodology to a novel dataset and show that the risk component is a nontrivial part of the transaction decision.
The association between homocysteine and systemic sclerosis: A review of the literature and meta-analysis

Abstract Objectives: The main objective of this study was to summarize the existing evidence and quantitatively evaluate whether serum/plasma levels of homocysteine (Hcy) were associated with sclerosis (SSc) diseases by performing a meta-analysis of previous studies. Methods: PubMed, Elsevier ScienceDirect and Cochrane Library databases were used to obtain all relative published literatures. Stata version 11.0 (StataCorp, College Station, TX) was used for statistical analysis. The effect size of each study was calculated by the standardized mean difference (SMD) with 95% confidence interval (CI) or quartiles. Results: A total of eight studies including 475 cases and 265 controls were finally included in this meta-analysis. We found significant between-study heterogeneity and conducted analyses using random-effects models. No significant association was found between the serum levels of Hcy and SSc (pooled SMD =1.382 μmol/L, 95%CI = −0.442 to 3.206, p = .137), but there are two outlier studies that deviate significantly from most other studies, which made it difficult to generalize these results. After excluding these two studies, six studies were included in the meta-analysis. The results showed that the serum levels of Hcy in SSc were significantly higher than that in healthy controls (pooled SMD = 1.182μmol/L, 95%CI = 0.230–2.134, p = .015). Conclusion: Serum/plasma levels of Hcy in SSc diseases were higher than that in healthy controls.
Do Older Employees Suffer More from Work Intensification and Other Intensified Job Demands? Evidence from Upper White-Collar Workers

Background: Working life today is characterized by acceleration and intensification due to social, and particularly technological, acceleration affecting the whole of society. These phenomena also affect working life by intensifying job demands, possibly imposing new job stressors on the workforce. At the same time workforce is aging, raising a question how older employees manage to cope with these work life changes. Methods: This study examined intensified job demands and their effects on occupational well-being from the age perspective utilizing Finnish survey data from upper white-collar workers (N = 2,200). Data was analyzed using multivariate analysis of covariance and hierarchical regression analyses. Results: The findings show that older employees experienced more work intensification and intensified knowledge- and skill-related learning demands, whereas younger employees experienced more intensified career-related planning and decision-making demands. Intensified job demands were related to occupational well-being (job burnout, work engagement), but were rarely age-specific. Conclusion: Aging does not necessarily mean higher intensified job demands, yet work intensification and intensified learning demands can be more common among older employees. However, more research is needed concerning the relationships between aging, intensified job demands and occupational well-being as empirical evidence is still scarce.
Motivation and burnout among top amateur rugby players.

INTRODUCTION Self-determination theory has proven to be a useful theoretical explanation of the occurrence of ill-being on a variety of accounts. Self-determination theory may also provide a useful explanation of the occurrence of athlete burnout. To date, limited evidence exists to support links between motivation and burnout. PURPOSE To examine relationships and potential causal directions among burnout and types of motivation differing in degree of self-determination. METHOD Data were collected on burnout using the Athlete Burnout Questionnaire and Sport Motivation Scale from 392 top amateur male rugby players. Structural equation modeling procedures were employed to evaluate a measurement model and three conceptually grounded structural models. One conceptual model specified concomitant (noncausal) relationships between burnout and motivations varying in self-determination. The other conceptual models specified causal pathways between burnout and the three motivation variables considered in the investigation (i.e., intrinsic motivation, external regulation, and amotivation). RESULTS Within the models, amotivation, the least self-determined type of motivation, had a large positive association with burnout. Externally regulated motivation had trivial and nonsignificant relationships with burnout. Self-determined forms of motivation (i.e., intrinsic motivation) exhibited significant negative associations with burnout. CONCLUSIONS Overall the results support the potential utility of a self-determination theory explanation of burnout. As all models displayed reasonable and comparable fits, further research is required to establish the nature (concomitant vs directional causal vs reciprocal causal) of the relationship between burnout and motivation.
Intravenous neridronate in the treatment of acute painful knee osteoarthritis: a randomized controlled study.

OBJECTIVE The aim of this randomized, double-blind, placebo-controlled study was to assess the efficacy of i.v. neridronate in controlling pain in patients with acute painful knee OA. METHODS Sixty-four patients with acute knee pain (<3 months duration) suffering from knee OA with an MRI showing bone marrow lesions (BMLs) were randomized to receive either neridronate 100 mg given four times over 10 days or placebo. After 50 days the patients underwent clinical assessment and a further MRI was performed. Primary outcome was pain changes measured by a visual analogue scale (VAS; range 0-100). Secondary endpoints were WOMAC pain score, McGill pain questionnaire and 36-Item Short Form Health Survey. BMLs were evaluated by whole-organ MRI score. RESULTS At the day of the last infusion the VAS decreased significantly more in the neridronate group [from 59.0 (s.d. 14.7) to 30.4 (s.d. 15.6); -48.4%; P < 0.001]. Fifty days later the VAS remained unchanged in the placebo group, while a further significant decrease was observed in the neridronate group [from 30.4 (s.d. 15.6) to 9.4 (s.d. 10.8); -69.1%; P < 0.001]. Significant improvements compared with the placebo group were found for most of the other indices of pain and quality of life. The BMLs score in the neridronate group showed significant decreases compared with basal values and those of the placebo-treated patients. Four months after the treatment, 72% of the placebo-treated patients resumed analgesic or anti-inflammatory drugs, but only 12.9% resumed treatment in the neridronate group. CONCLUSION In patients with acute painful knee OA, four infusions of neridronate are associated with a clinically relevant pain benefit. TRIAL REGISTRATION ClinicalTrials.gov (http://clinicaltrials.gov), NCT01803360.
Progesterone promotes maternal–fetal tolerance by reducing human maternal T‐cell polyfunctionality and inducing a specific cytokine profile

Progesterone is a steroid hormone essential for the maintenance of human pregnancy, and its actions are thought to include promoting maternal immune tolerance of the semiallogenic fetus. We report that exposure of maternal T cells to progesterone at physiological doses induced a unique skewing of the cytokine production profile of CD4+ and CD8+ T cells, with reductions not only in potentially deleterious IFN‐γ and TNF‐α production but also in IL‐10 and IL‐5. Conversely, production of IL‐4 was increased. Maternal T cells also became less polyfunctional, focussing cytokine production toward profiles including IL‐4. This was accompanied by reduced T‐cell proliferation. Using fetal and viral antigen‐specific CD8+ T‐cell clones, we confirmed that this as a direct, nonantigen‐specific effect. Yet human T cells lacked conventional nuclear progesterone receptors, implicating a membrane progesterone receptor. CD4+ and CD8+ T cells responded to progesterone in a dose‐dependent manner, with subtle effects at concentrations comparable to those in maternal blood, but profound effects at concentrations similar to those at the maternal–fetal interface. This characterization of how progesterone modulates T‐cell function is important in understanding the normal biology of pregnancy and informing the rational use of progesterone therapy in pregnancies at risk of fetal loss.
On the molecular basis of transition mutations. Frequency of forming 2-aminopurine-cytosine base mispairs in the G X C----A X T mutational pathway by T4 DNA polymerase in vitro.

An in vitro model system including wild-type T4 DNA polymerase, the mutagenic nucleotide analogue 2-aminopurine deoxyribonucleoside triphosphate, and poly[d(A,C)] X oligo(dT) poly(dC) X oligo(dG) template-primers is used to measure the frequency of 2-aminopurine X cytosine base mispairs formed in the G X C----A X T mutational pathway. Incorporation and turnover of the analogue into DNA is dependent on the presence of cytosine on the template strand and is reduced significantly in the presence of dGTP. 2-Aminopurine X cytosine mispairs are observed to occur at a 2-3 order of magnitude greater frequency than adenine X cytosine mispairs. The frequency of inserting 2-aminopurine deoxyribonucleoside monophosphate in place of dGMP opposite template cytosine sites is about 3-6% when either strong or weak base-stacking partners are present on the primer strand. However, enzymatic proofreading of the mispair strongly depends on base-stacking partners. Greater than 85% of misinserted 2-aminopurine deoxynucleotides are excised whenever the mispairs are formed next to 5'-primer thymine sites. A 5-fold reduction in proofreading frequency occurs when the mispair is formed with 2-aminopurine deoxynucleoside monophosphate stacked adjacent to a 5'-primer guanine. The frequency of 2-aminopurine X cytosine base mispair formation in the G X C----A X T pathway is similar to that found previously in the A X T----G X C pathway (Watanabe, S. M., and Goodman, M.F. (1981) Proc. Natl. Acad. Sci. U.S.A. 78, 2864-2868). We propose a criterion for base selection by DNA polymerase to account for the unexpected similarity in base mispairing rates in the two transition pathways.
Is grip strength related to neuromuscular admittance during steering wheel control?

Continuous haptic feedback can improve manual control task performance and application methods on steering wheel (haptic steering guidance) have been studied. However, the current haptic steering guidance systems assume there is an average, constant driver's response to force (which can be quantified as the admittance). To improve the performance of haptic steering guidance, the guidance system should be adaptive to the inter and intra-driver variability in admittance. To achieve this we need to be able to get accurate, non-evasive estimates of driver neuromuscular admittance. We believe the gripping force with which drivers control the steering wheel might be a good parameter to estimate admittance. The goal of this paper is to investigate the correlation between grip strength and human admittance of a driver holding the steering wheel. A relax task and a position task with two different grip conditions, loose and tight, are performed. The results of the experiment show that there should be an inverse relationship between grip strength and admittance. Whether it is possible to differentiate admittance between tasks through grip strength alone remains to be seen as we could not measure grip strength directly. Future experiments with grip pressure sensors will be carried out to establish a quantitative correlation between grip strength and neuromuscular admittance.
Binding sites in Escherichia coli dihydrofolate reductase communicate by modulating the conformational ensemble.

To explore how distal mutations affect binding sites and how binding sites in proteins communicate, an ensemble-based model of the native state was used to define the energetic connectivities between the different structural elements of Escherichia coli dihydrofolate reductase. Analysis of this model protein has allowed us to identify two important aspects of intramolecular communication. First, within a protein, pair-wise couplings exist that define the magnitude and extent to which mutational effects propagate from the point of origin. These pair-wise couplings can be identified from a quantity we define as the residue-specific connectivity. Second, in addition to the pair-wise energetic coupling between residues, there exists functional connectivity, which identifies energetic coupling between entire functional elements (i.e., binding sites) and the rest of the protein. Analysis of the energetic couplings provides access to the thermodynamic domain structure in dihydrofolate reductase as well as the susceptibility of the different regions of the protein to both small-scale (e.g., point mutations) and large-scale perturbations (e. g., binding ligand). The results point toward a view of allosterism and signal transduction wherein perturbations do not necessarily propagate through structure via a series of conformational distortions that extend from one active site to another. Instead, the observed behavior is a manifestation of the distribution of states in the ensemble and how the distribution is affected by the perturbation.
Effects of Selective Brain Cooling in Patients with Severe Traumatic Brain Injury: A Preliminary Study

We prospectively investigated noninvasive selective brain cooling (SBC) in patients with severe traumatic brain injury. Sixty-six in-patients were randomized into three groups. In one group, brain temperature was maintained at 33-35 °C by cooling the head and neck (SBC);in a second group, mild systemic hypothermia (MSH; rectal temperature 33-35°C) was produced with a cooling blanket; and a control group was not exposed to hypothermia. Natural re-warming began after 3 days. Mean intracranial pressure 24, 48 or 72 h after injury was significantly lower in the SBC group than in the control group. Mean serum superoxide dismutase levels on Days 3 and 7 after injury in the SBC and MSH groups were significantly higher than in the control group. The percentage of patients with a good neurological outcome 2 years after injury was 72.7%, 57.1% and 34.8% in the SBC, MSH and control groups, respectively. Complications were managed without severe sequelae. Non-invasive SBC was safe and effective.
The use of alternative therapies by patients with Parkinson’s disease

Objective: To determine the prevalence and spectrum of use of alternative therapy (AT) by patients with PD and to determine whether use of AT correlates with demographic, social, or disease-specific characteristics. Methods: The authors administered a structured questionnaire, by interview, regarding the use of AT to 201 patients with PD. Demographic, social, and disease-specific characteristics were recorded for all patients. Results: Eighty-one patients (40%) used at least one AT. Vitamins and herbs, massage, and acupuncture were most common. Users of AT were younger (p = 0.0021) and had a younger age at onset of PD (p = 0.0011) than nonusers of AT. There was no correlation with sex or race. Patients who used AT had a higher income (p = 0.038) and education level (p = 0.006) than did nonusers of AT. There was no association between the use of AT and the Hoehn and Yahr score, duration of PD, duration of treatment with levodopa, surgery for PD, and presence of fluctuations. Conclusions: The use of AT is common in patients with PD. The age at onset of PD is the most potent predictor of AT use. There is no association between the use of AT and the severity of PD. The widespread and largely unexamined use of AT for PD requires more attention. This should be directed at testing their safety and efficacy and improving physician and patient knowledge about the potential benefits, costs, limitations, and risks of AT.
Long-term results of laryngotracheal resection for benign stenosis from a series of 109 consecutive patients.

OBJECTIVES Long-term results of patients undergoing laryngotracheal resection for benign stenosis are reported. This is the largest series ever published. METHODS Between 1991 and March 2015, 109 consecutive patients (64 males, 45 females; mean age 39 ± 10.9 years) underwent laryngotracheal resection for subglottic postintubation (93) or idiopathic (16) stenosis. Preoperative procedures included tracheostomy in 35 patients, laser in 17 and laser plus stenting in 18. The upper limit of the stenosis ranged between actual involvement of the vocal cords and 1.5 cm from the glottis. Airway resection length ranged between 1.5 and 6 cm (mean 3.4 ± 0.8 cm) and it was over 4.5 cm in 14 patients. Laryngotracheal release was performed in 9 patients (suprahyoid in 7, pericardial in 1 and suprahyoid + pericardial in 1). RESULTS There was no perioperative mortality. Ninety-nine patients (90.8%) had excellent or good early results. Ten patients (9.2%) experienced complications including restenosis in 8, dehiscence in 1 and glottic oedema requiring tracheostomy in 1. Restenosis was treated in all 8 patients with endoscopic procedures (5 laser, 2 laser + stent, 1 mechanical dilatation). The patient with anastomotic dehiscence required temporary tracheostomy closed after 1 year with no sequelae. One patient presenting postoperative glottic oedema underwent permanent tracheostomy. Minor complications occurred in 4 patients (3 wound infections, 1 atrial fibrillation). Definitive excellent or good results were achieved in 94.5% of patients. Twenty-eight post-coma patients with neuropsychiatric disorders showed no increased complication and failure rate. CONCLUSIONS Laryngotracheal resection is the definitive curative treatment for subglottic stenosis allowing very high success rate at long term. Early complications can be managed by endoscopic procedures achieving excellent and stable results over time.