Miracle-dz/UniFAR-FTUs huggingface dataset:
Customers’ Expectations and Perceptions of Service Quality: The Case of a Retail Pharmacy Chain in South Africa

Recent legislative changes have permitted rapid expansion of pharmacy chains in South Africa. The early effect of this appears to be lowered prices and greater competition amongst pharmacy chains. Whilst research has been conducted on general aspects of customer service quality in various industries, there appears to be few studies on customer satisfaction within the South African retail pharmaceutical sector in particular. This paper therefore seeks to assess customer satisfaction at a selected pharmacy chain within the greater Durban area. A study was conducted among 400 customers, using the SERVQUAL model as the measuring instrument. The results indicate that there are gaps between customers’ expectations and perceptions on the five service quality dimensions. The chi square test was performed to determine significant differences between four biographical variables viz. gender, age, educational level of respondents and frequency of shopping versus the five dimensions of service quality, on both expectations and perceptions. Recommendations are presented on how the pharmacy chain can enhance service quality in order to offer superior customer service in the face of growing competition. DOI: 10.5901/mjss.2014. v5n20p2648
The internationalisation of born global and international new venture SMEs

Purpose – The purpose of this paper is to examine whether differences exist between born global (BG) firms and international new ventures (INVs) in respect of their performance in overseas markets. These terms have arguably been used as interchangeable to characterise firms that internationalized rapidly, typically but not exclusively within three years of their business start‐up. The term “global” suggests firms have a presence in at least the world's triad regions and arguably a commitment spread across them. INVs, however, may have internationalized quickly to address opportunities but without necessarily a global presence.Design/methodology/approach – The methodology in this exploratory study employs both quantitative but also primarily a qualitative methodology involving 21 technologically oriented small‐ and medium‐sized enterprises (SMEs) based in the UK. This methodological approach is used to assess the strategies used by the two types of firms after their start‐up phase and the factors that shap.
DEVELOPMENT OF COOPERATIVE NORMS IN THE BUYER-SUPPLIER RELATIONSHIP: THE CHINESE EXPERIENCE

Cooperative norms are a critical governance mechanism of the buyer-supplier relationship. Prior studies generally assume that cooperative norms are pre-existing and utilize norms as an antecedent to other constructs. Little attention has been paid to the antecedents of the decision to develop cooperative norms. In this paper, we draw upon transaction cost economics and resource dependence theory to develop a model that depicts the key factors that determine cooperative norms. Based on the results derived from an empirical study of 278 Chinese companies, we find that these factors significantly impact cooperative norms. The study also reveals that cooperative norms positively influence suppliers' performance, which subsequently affects buyers' satisfaction.
Value creation in collaboration between software suppliers and customers: suppliers’ perspective

This study is concentrated on value creation in the context of the software business, especially the enterprise system solution business. The purpose of this study is to increase both theoretical and empirical understanding of value creation in this specific context through the integration of economic value creation theories and software development. The theoretical framework includes the perspectives of both the customers and the suppliers, and their interactions during the value creation process. For this study, the main perspective is that of the supplier. The customer, therefore, is like a mirror from which the requirement for action (on the part of suppliers) originates. The main focus is the understanding that the use period is important, which concretises the made-value offering and determines the future of the collaboration. The empirical material is collected through interviews of four software organisations. The research strategy is the qualitative case study, which is fulfilled with the narrative method. The interviews performed were quite expansive, and allowed interviewees to share examples and real-life stories. As a result of the empirical analysis, the use period is at the heart of the value-creation process, because the software’s success depends on the use experience. Understanding both the reason and the use purpose is the key to support customer’s use process. Learning from the customer’s use process is extremely important and increases everyday interaction. It is true, that the focus broadens from evaluating basic attributes of the relationship as a whole to include an evaluation of cumulative experiences. Satisfaction is strongly linked to behavioural outcomes. While use experiences have been researched widely, but their connection to economic theories (and value in particular) is not very well known. Theoretically, the challenge is to connect abstract value concepts to the more practical area of software business theories. This study finds connection by explicitly tying user experiences with the types of efforts that suppliers make (and the theories that inform these efforts) to create value.
Sulfation of chondroitin/dermatan sulfate by cystic fibrosis pancreatic duct cells is not different from control cells.

Cystic fibrosis is associated with mutations of the cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-regulated plasma membrane chloride channel. Cystic fibrosis patients have been reported to possess elevated sulfation of glycoconjugates, which may contribute to the pathogenesis of the disease. Sulfation of glycosaminoglycans by a cystic fibrosis pancreatic adenocarcinoma cell line homozygous for DeltaF508 (CFPAC-1), a control pancreatic cell line (PANC-1), two CFPAC-1 cell lines transfected with the gene for CFTR (PLJ-CFTR-4.7, TR20), and a mock-transfected CFPAC-1 control (PLJ-6) was investigated. Cells were radiolabeled with [35S]sulfate and [3H]glucosamine, and glycosaminoglycans secreted into the medium after 24 and 72 h were isolated. Chondroitinase ABC digestion of chondroitin/dermatan sulfate allowed the recovery of disaccharides which were analyzed for their degree of sulfation by strong anion-exchange HPLC. No differences in the extent of sulfation by any of the cell lines were noted. However, glycoaminoglycans synthesized by cystic fibrosis cells consistently exhibited twofold higher [35S]-sulfate:[3H]glucosamine ratios than the controls. We conclude that CFTR plays no role in the sulfation of chondroitin/dermatan sulfate by pancreatic cells and that isotope incorporation ratios alone are insufficient evidence of changes in sulfation levels.
Specific and Transient Up-Regulation of Proprotein Convertase 6 at the Site of Embryo Implantation and Identification of a Unique Transcript in Mouse Uterus During Early Pregnancy1

Abstract The present investigation was conducted to identify and characterize an mRNA that was found by RNA differential display to be uniquely regulated at the sites of embryo implantation in mouse uterus. This mRNA was upregulated at the sites of blastocyst attachment at implantation and was identified as proprotein convertase 6 (PC6). PC6 mRNA level was low in the nonpregnant and early pregnant uterus before embryo implantation commenced (before Day 4.5, vaginal plug = Day 0). During the initiation and progression of blastocyst attachment (around Day 4.5), the mRNA was dramatically upregulated only at the implantation sites. The increased transcription was maintained on Day 5.5; the mRNA level declined slightly on Day 6.5 and then fell sharply to reach the nonpregnant level around Days 8.5–10.5. Thus, the upregulation is transient and coincides with the period of embryo attachment and implantation; it is also very specific to implantation sites. In situ hybridization analysis localized the mRNA expression predominantly in the decidual cells immediately surrounding the implanting embryo at the antimesometrial pole. Additionally, multiple mRNA species resulting from alternative splicing were observed in the uterus, as previously reported in the intestine and brain, and further analysis of these transcripts identified a uterine-specific PC6 mRNA. These data lead us to suggest that PC6 plays an important role in the processes of stromal cell decidualization and embryo implantation.
Whole‐exome sequencing detects somatic mutations of IDH1 in metaphyseal chondromatosis with D‐2‐hydroxyglutaric aciduria (MC‐HGA)

We used exome sequencing of blood DNA in four unrelated patients to identify the genetic basis of metaphyseal chondromatosis with urinary excretion of D‐2‐hydroxy‐glutaric acid (MC‐HGA), a rare entity comprising severe chondrodysplasia, organic aciduria, and variable cerebral involvement. No evidence for recessive mutations was found; instead, two patients showed mutations in IDH1 predicting p.R132H and p.R132S as apparent somatic mosaicism. Sanger sequencing confirmed the presence of the mutation in blood DNA in one patient, and in blood and saliva (but not in fibroblast) DNA in the other patient. Mutations at codon 132 of IDH1 change the enzymatic specificity of the cytoplasmic isocitrate dehydrogenase enzyme. They result in increased D‐2‐hydroxy‐glutarate production, α‐ketoglutarate depletion, activation of HIF‐1α (a key regulator of chondrocyte proliferation at the growth plate), and reduction of N‐acetyl‐aspartyl‐glutamate level in glial cells. Thus, somatic mutations in IDH1 may explain all features of MC‐HGA, including sporadic occurrence, metaphyseal disorganization, and chondromatosis, urinary excretion of D‐2‐hydroxy‐glutaric acid, and reduced cerebral myelinization. © 2011 Wiley Periodicals, Inc.
Facilitation From Hand Muscles Innervated by the Ulnar Nerve to the Extensor Carpi Radialis Motoneurone Pool in Humans: A Study With an Electromyogram-Averaging Technique

Summary: Effects of low-threshold afferents of hand muscles innervated by the ulnar nerve on an excitability of the extensor carpi radialis (ECR) motoneurone pool in humans were examined using an electromyogram-averaging (EMG-A) technique. Changes of EMG-A of ECR exhibiting 10% of the maximum contraction by electrical stimulation to the ulnar nerve at the wrist (ES-UN) and mechanical stimulation to the hypothenar muscles (MS-HTM) and first dorsal interosseus (MS-FDI) were evaluated in eight normal human subjects. The ES-UN with the intensity immediately below the motor threshold and MS-HTM and -FDI with the intensity below the threshold of the tendon(T)-reflex were delivered. Early and significant peaks in EMG-A were produced by ES-UN, MS-HTM, and MS-FDI in eight of eight subjects. The mean amplitudes of the peaks by ES-UN, MS-HTM, and MS-FDI were, respectively, 121.9%, 139.3%, and 149.9% of the control EMG (100%). The difference between latencies of the peaks by ES-UN and MS-HTM, and ES-UN and MS-FDI was almost equivalent to that of the Hoffmann(H)- and T-reflexes of HTM and FDI, respectively. The peaks by ES-UN, MS-HTM, and MS-FDI diminished with tonic vibration stimulation (TVS) to HTM and FDI, respectively. These findings suggest that group Ia afferents of the hand muscles facilitate the ECR motoneurone pool.
Pituitary tumour localization in patients with Cushing's disease by magnetic resonance imaging. Is there a place for petrosal sinus sampling?

OBJECTIVE We wished to analyse the relative value and diagnostic accuracy of bilateral simultaneous inferior petrosal sinus blood sampling for plasma ACTH measurements when compared with pituitary magnetic resonance imaging (MRI) for the preoperative localization of microadenoma (tumour diameter <10 mm) within the pituitary fossa in patients with Cushing's disease.
Towards an ecological collaborative relationship management A “co‐opetive” perspective

Attempts to address how organizations are responding to the growing complexities of global business, technology, and virtual organizations. Argues that organizations can co‐operate and compete at the same time in order to be more effective in the marketplace utilizing a relationship perspective. This is why we have integrated the concepts cooperation and effectiveness, to create the new “co‐opetive” terminology. An ecological collaborative value system (CVS) has been developed. The behaviour of the system is affected by the condition of its components, and the system components are affected by environmental conditions. CVS suggests that customers, suppliers, distributors, competitors, and other organizations are equal partners in the system. Argues that it is imperative for a successful alliance and relationship between the collaborators to communicate and cooperate in an atmosphere of frank debate, trust, interdependence, and mutual positive expectation so that the mutual benefits and interests may be achieved. This mechanism may enable each component of the system to monitor its performance and to adjust its operation to ensure uniform quality of its input‐output. In short, it may allow the system to learn, adapt and evolve.
Hyperresponsive B Cells in CD22-Deficient Mice

CD22 is a surface glycoprotein of B lymphocytes that is rapidly phosphorylated on cytoplasmic tyrosines after antigen receptor cross-linking. Splenic B cells from mice with a disrupted CD22 gene were found to be hyperresponsive to receptor signaling: Heightened calcium fluxes and cell proliferation were obtained at lower ligand concentrations. The mice gave an augmented immune response, had an expanded peritoneal B-1 cell population, and contained increased serum titers of autoantibody. Thus, CD22 is a negative regulator of antigen receptor signaling whose onset of expression at the mature B cell stage may serve to raise the antigen concentration threshold required for B cell triggering.
Incidence of dementia in a Kashmiri migrant population

Background: Mishriwala is one of five exclusive clusters of Kashmiri migrants established in 1990 to accommodate Kashmiri Pandit families who left Kashmir valley in the wake of militancy. Mishriwala migrant camp has seen minimal immigration and out-migration since its establishment. In an earlier study we reported on the prevalence of dementia amongst a Kashmiri migrant population. That study was conducted in the migrant camp at Mishriwala, 12 km west of Jammu city, the winter capital of Jammu and Kashmir State. We have developed standardized study methods and instruments for use in the Kashmiri-speaking population, which we used for screening for dementia during the prevalence study. We now report the results of a 1-year prospective study carried out to find out the incidence of dementia in the same population. Aim: To ascertain the incidence of dementiain the Kashmiri Pandit population aged 60 years and above. Materials and Methods: A 1-year, prospective, epidemiological study of 186 subjects aged 60 years and above, using cognitive and functional ability screening and clinical evaluation. Results: The incidence of dementia in this population was 5.34 cases per 1000 person-years.
Determinants of Capital Structure of Listed Oil Marketing Companies in Ghana

Capital structure decisions are the most crucial decisions taken by corporate organizations, as these decisions have massive impact on the overall cost of capital weighted average and the resultant profitability and market value of shares. Most of the researches conducted on capital structure concluded that there is an optimal capital structure that is affected by a variety of internal and external factors. These factors usually differ from country to country and industry to industry. This paper using a case study methodology, investigated the determinant of capital structure of oil companies in Ghana. The study examined how internal factors such as profitability, asset tangibility, growth, size and riskiness of a firm impacts on the capital structure of the two listed oil marketing companies in Ghana (GOIL and TOTAL) for the period between 2005 and 2014 using ordinary least square regression. The findings indicated that all the factors have significant impact on financial leverage.
Information Technology Use and Firm's Perceived Performance in Supply Chain Management

Purpose: This article proposes a theoretical model to investigate (a) a positive direct relationship between the specific use of ITs (applied to management) and the firm's performance as perceived by retailers and (b) a positive indirect relationship through information quality and information sharing. Design/Methodology/Approach: The theoretical model proposed in this paper is contrasted using structural equation modelling of the retail distribution channel for home appliances. Findings: The research shows that there is no positive direct relationship between the specific use of ITs and the retailer's perceived performance in the relationship with the provider. The results do, however, provide evidence for a positive indirect relationship through both information sharing and satisfaction obtained from the relationship with the provider. Research Limitations: The analysis has been developed from the retail perspective. We suggest that future research focus on the retailer's and the provider's perspectives. Practical Implications: In the context of SCM, the competitive advantages achieved through IT use derive from a better network of relationships between the firms involved as a result of greater information quality and information sharing. Specific use of ITs stimulates greater information sharing between retailer and provider and thus greater satisfaction and better perceived performance of the retailer in the relationship with the provider. However, the effect of IT use on information sharing occurs only through the quality of the information shared. Originality/Value: The study shows that information quality is an antecedent of information sharing and that both information quality and information sharing act as necessary conditions for improving the retailer's perceived performance in the relationship with the provider. This article develops a measurement scale to evaluate the intensity of IT use. Finally, the research confirms that firm performance can be modeled as a second-level latent variable composed of three different dimensions (economic benefits, marketing benefits, and adaptation benefits).
Gap‐scan deletion analysis of Bacillus subtilis RNase P RNA

We carried out an exhaustive deletion analysis of Bacillus subtilis ribonuclease P (RNase P) RNA, seeking sequences that are essential for its catalytic activity. A collection of partially deleted RNase P RNA genes was used to construct templates for synthesis, by in vitro transcription, of circularly permuted RNA molecules that lack various wild‐type sequences. The mutant RNAs were assayed for catalytic activity in vitro, using a precursor of B. subtilis tRNAAsp as a substrate. Gap‐scan deletion analysis revealed that most of the RNase P RNA sequence is important for activity; only two substantive deletions did not dramatically inhibit pre‐tRNA processing in vitro. One part of the molecule (nucleotides 225‐270) seemed particularly sensitive to deletion, but considering a collection of mutants with overlapping deletion gaps, it was possible to remove every residue in the RNase P RNA without completely abolishing its catalytic activity. Thus, the catalytic mechanism of RNase P does not depend absolutely on a single, particular nucleotide or local sequence for activity. — Waugh, D. S. , and Pace, N. R. Gap‐scan deletion analysis of Bacillus subtilis RNase P RNA. FASEB J. 7: 188‐195; 1993.
The Villous Stromal Constituents of Complete Hydatidiform Mole Differ Histologically in Very Early Pregnancy From the Normally Developing Placenta

Histologic distinction between complete hydatidiform moles and nonmolar abortuses in early pregnancy is often extremely difficult. This study details the chronologic changes that occur in normal placenta, especially in the villous stroma during gestational weeks 4 to 12 and compares the findings in 63 normal placentas and 73 early complete moles. Over time, the chorionic villi in normal placenta showed gradual but recognizable alterations, from basophilic/hypocellular and nonvascular stroma to basophilic/cellular stroma containing angiogenic cell cords (immature blood vessels), and then to loose, edematous/reticular stroma with mature blood vessels containing vascular lumina and hematopoietic components. A basophilic stroma, which was frequently seen in early complete moles, was a constant feature of chorionic villi younger than week 7 in normal placenta, but had disappeared after week 8, except in the newly branched sprouts. Trophoblastic proliferation was virtually unrecognizable in 59% of early complete moles, whereas circumferential trophoblastic sprouts during weeks 4 to 6 of normal placenta can be mistaken as that of complete moles. Few or no mature blood vessels and excessive stromal karyorrhexis are characteristic features of early complete moles, even in the absence of trophoblastic proliferation, but they are occasionally found in normal placenta younger than week 7. Although many features of normal and molar placenta were similar during the earliest weeks (5 to 6) including basophilic stroma, angiogenic cell cords (immature blood vessels), and often circumferential trophoblastic sprouts and proliferation, already by that time early moles showed significantly greater percentages of stromal cells undergoing karyorrhexis and apoptosis compared with normal placenta (37.6% vs. 5.4%). These results indicate the histologic features do exist early on in pregnancy to differentiate normal from molar pregnancy. Further, it points out that complete hydatidiform mole in addition to being disease of trophoblastic proliferation is also associated with defects in vasculogenesis and maturation of villous stromal constituents.
The Use of Computerised Accounting Systems in Small Business

This paper is based on a research project which was designed to investigate small business usage of a computerised accounting system (CAS) to ascertain if there are obstacles that prevent small businesses from migrating to such a system. Two groups of small businesses are surveyed. Those that currently use a CAS and those that do not. The purpose of this comparison is to determine what were the major influences in their decision to use or not use accounting software for their business. A secondary objective was to learn more about the influence and role (if any) played by their accountant in their decision. The development of an understanding of the obstacles that inhibit the use of a CAS will be useful in the building of strategies to encourage greater efficiency in small business record keeping.