Miracle-dz/UniFAR-FTUs huggingface dataset:
Fatigue in patients with chronic hepatitis C

summary. In numerous studies of symptoms in patients with chronic hepatitis C there has been no systematic assessment of both fatigue and extrahepatic manifestations. Our objective was to assess the prevalence of fatigue in patients with hepatitis C virus (HCV) infection, and to identify associations between fatigue and clinical and biological hepatic and extrahepatic manifestations. We studied 1614 patients. Data were prospectively recorded during the first visit of patients infected with HCV and the prevalence of fatigue and its association with dermatological, rheumatological, neurological and nephrological manifestations; diabetes; arterial hypertension; auto‐antibodies, and cryoglobulinaemia were assessed. Then, using multivariate analysis, we identified demographic, biochemical, immunological, virological, and histological factors associated with the presence of fatigue.
‘The law is not for the poor’: Land, law and eviction in Luanda

This article investigates how an existing two-tiered land tenure system creates a hybrid space that blurs, and essentially questions and problematizes the boundaries of the formal/informal divide as presented within Angolan political and legal discourses. It showcases how urban formality and informality exist alongside each other in Luanda and how people take recourse to both formal and informal channels in attempts to secure housing, land tenure and livelihoods in the city. Through case studies, the article describes how small-scale farmers in Luanda's northern municipality of Cacuaco lost their lands to urban development in 2009–10 and the ensuing circumstances in which formal rights and informal land tenure became intermeshed and ambiguous. As the case studies illustrate, a gap exists between the legal code and practice on the ground. This gap is represented in how Angola's postconflict land strategy, with its forced evictions and demolitions of houses and neighbourhoods, often with little or no compensation, is at odds with the Angolan Land Law, which states that land may only be expropriated by the state or local authorities for specific public use and must be justly compensated.
Evidence for increased beta-adrenoreceptor responsiveness induced by 14 days of simulated microgravity in humans.

We studied hemodynamic responses to alpha- and beta-receptor agonists in eight healthy men before and after 14 days of 6 degrees head-down tilt (HDT) to test the hypothesis that increased adrenoreceptor responsiveness is induced by prolonged exposure to simulated microgravity. Steady-state infusions of isoproterenol (Iso) at rates of 0.005, 0.01, and 0.02 microgram.kg-1.min-1 were used to assess beta 1- and beta 2-adrenoreceptor responsiveness. Infusions of phenylephrine (PE) at rates of 0.25, 0.50, and 1.00 microgram.kg-1.min-1 were used to assess responsiveness of alpha 1-vascular adrenoreceptors. Slopes calculated from linear regressions between Iso and PE doses and changes in beat-to-beat heart rate, blood pressure, and leg vascular resistance (occlusion plethysmography) for each subject were used as an index of alpha- and beta-adrenoreceptor responsiveness. HDT increased the slopes of heart rate (1,056 +/- 107 to 1,553 +/- 83 beats micrograms-1.kg-1.min-1; P = 0.014) and vasodilation (-469 +/- 111 to -1,446 +/- 309 peripheral resistance units.microgram-1.kg-1.min-1; P = 0.0224) to Iso infusion. There was no alteration in blood pressure or vascular resistance responses to PE infusion after HDT. Our results provide evidence that simulated microgravity causes selective increases in beta 1- and beta 2-adrenoreceptor responsiveness without affecting alpha 1-vascular adrenoreceptor responses.
The effect of continuous repetition training and intra-set rest training on bench press strength and power.

AIM The purpose of this research was to compare the effects of continuous repetition and intra-set rest training on maximal strength and power output of the upper body. METHODS The 6 repetition maximum (6RM) and bench press throw power output against masses of 20, 30 and 40 kg of 26 elite junior male basketball and soccer players were tested on 2 separate occasions for reliability purposes. Subjects were then randomly assigned to either a continuous repetition (CR - 4 sets x 6 repetitions) or intra-set rest (ISR - 8 sets x 3 repetitions) training regime over 6-weeks. Volume (sets x repetitions x %6RM) between groups was equated and both groups completed all sets in the same time period (13 minutes and 20 seconds). The total concentric work time was determined to identify differences in training regimes. Independent sample t-tests on preintervention and postintervention percentage change scores were analysed for significant differences (p<0.05). RESULTS The observed coefficients of variation (1.7% to 4.8%) and intraclass correlation coefficients (r=0.87 to 0.98) indicated stability of these measures across testing occasions. The CR group significantly increased 6RM strength (9.7%) compared with the ISR group (4.9%). The total concentric work time was significantly longer in CR training than ISR (36.03+/- 4.03 s and 31.74+/-4.71 s; p=0.13). Power output increases across the 20, 30 and 40 kg loads ranged from 5.8% to 10.9% for both training groups but the between-group percentage change scores were not significantly different. CONCLUSIONS Bench press training involving 4 sets of 6 continuous repetitions elicited a greater improvement in bench press strength than 8 sets of 3 repetitions at the same percentage load of their 6RM. Both ISR and CR training were equally effective in increasing power output.
Improved in vitro fertilization outcomes after treatment of subclinical hypothyroidism in infertile women.

OBJECTIVE To assess the effect of treatment of maternal subclinical hypothyroidism on infertility outcome. METHODS Between April 1, 2006, and April 22, 2007, we conducted a prospective, randomized trial in infertile women with subclinical hypothyroidism who elected to undergo in vitro at the Shatby University Hospital for Women in Alexandria, Egypt. Patients were randomly assigned to 2 groups: treatment group (group A) and placebo group (group B). Male-factor infertility was ruled out. One month before the assisted reproduction technology procedure, group A underwent levothyroxine treatment with a dosage of 50 to 100 mcg daily, while group B started placebo. All patients underwent controlled ovarian stimulation. Patients who achieved pregnancy were followed up throughout their pregnancy until delivery. Levothyroxine treatment and placebo were maintained throughout pregnancy in group A and group B, respectively. RESULTS Mean thyrotropin value was significantly lower in group A than in group B (1.1 ± 0.3 mIU/L vs 4.9 ± 0.7 mIU/mL, respectively). Mean number of retrieved oocytes was similar in both groups (6.19 ± 0.74 [group A] vs 6.08 ± 0.79 [group B]). Miscarriage rate was significantly lower in group A than in group B (9% vs 13%, respectively), and the clinical pregnancy rate and delivery rate were significantly higher in group A than in group B (35% and 10% vs 26% and 3%, respectively), indicating that the quality, not the quantity, of retrieved oocytes was more important. CONCLUSION These preliminary data suggest that levothyroxine supplementation should be recommended to achieve clinical pregnancies in women with subclinical hypothyroidism who are undergoing in vitro fertilization-intracytoplasmic sperm injection.
Hypervascular liver lesions: differentiation of focal nodular hyperplasia from malignant tumors with dynamic gadolinium-enhanced MR imaging.

The differentiating points between focal nodular hyperplasia (FNH) and malignant hypervascular liver lesions were studied at dynamic gadolinium-enhanced magnetic resonance (MR) imaging. Thirty-six patients with 50 hypervascular lesions (28 FNH, 12 hepatocellular carcinoma, nine metastases, and one cholangiocarcinoma) underwent unenhanced spin-echo (SE) T1- and T2-weighted imaging and T1-weighted gradient-recalled-echo imaging before and repeatedly for 10 minutes after intravenous bolus injection of gadopentetate dimeglumine. On unenhanced SE images, the signal intensity of 25 FNH lesions (89%) and 10 malignant tumors (45%) was homogeneous. A central scar was detected in 12 FNH lesions (43%) and in none of the malignant tumors. On dynamic gadolinium-enhanced images, all lesions had early vigorous enhancement that was homogeneous in 27 FNH lesions (96%) and in seven malignant tumors (32%) (P < .001). After administration of gadopentetate dimeglumine, central scars were seen in 22 FNH lesions (79%) and in one malignant tumor (4%) (P < .001). All FNH lesions (100%) and six malignant tumors (27%) had well-defined enhancement (P < .001). There was overlap in the enhancement pattern between hypervascular malignant lesions and FNH, but by using the combination of unenhanced and enhanced images, they could be distinguished.
Impact of influenza and respiratory syncytial virus on mortality in England and Wales from January 1975 to December 1990

Summary The effects of influenza A and B and RSV on mortality in England and Wales were assessed by regression analysis for the period 1975–90. Morbidity data from sentinel practices were used to calculate 4-weekly rates of aggregated upper respiratory tract infections (URTI); PHLS laboratory reports were used as indices of infection, and 4-weekly death rates from all causes, excluding childbirths, were used to study relationships with mortality. Deaths correlated strongly with influenza A and B reports, temperature, and interactions between aggregated URTI and temperature, and RSV outbreaks and temperature. Estimates of ‘seasonal’ 4-weekly mortality associated with URTI were made by substituting into primary regression models the mean of annual trough consultation rates for aggregated URTI and baseline values for RSV and influenza. Peak 4-weekly mortality associated with URTIs was estimated at c. 24000 and c. 28000 during combined influenza and RSV epidemics of 1975–6 and 1989–90 respectively. Secondary regression analysis was carried out with the estimated ‘seasonal’ 4-weekly deaths associated with URTI as dependant variable and laboratory data as regressors. Estimated excess mortality associated with influenza was considerable even during years without major epidemics. Overall during the 15 winters the estimated mortality associated with RSV was 60–80 % more than that associated with influenza. The modelling permits only a crude estimate of RSV associated mortality. None the less it suggests that RSV is an important cause of winter mortality.
Evaluation of Factor V Leiden, Prothrombin G20210A, MTHFR C677T and MTHFR A1298C gene polymorphisms in retinopathy of prematurity in a Turkish cohort

ABSTRACT Background: To assess Factor V Leiden (FVL) (rs6025), Prothrombin G20210A (rs1799963), MTHFR C677T (rs1801133), and MTHFR A1298C (rs1801131) gene mutations as risk factors in the development of retinopathy of prematurity (ROP). Materials and methods: A total of 105 children were included in this cross-sectional study. Patients were divided into two groups. The study group consisted of 55 infants with a history of ROP and the control group comprised 50 healthy infants with term birth. All subjects were screened for the presence of certain mutations (FVL, Prothrombin G20210A, MTHFR C677T and MTHFR A1298C) by Real-Time PCR at 1 year of age. Results: The mean gestational age (GA) and birth weight (BW) of the study group were, 28.65 ± 2.85 weeks and 1171 ± 385.74 g, respectively. There were no significant differences of genotype and allele frequency of Prothrombin G20210A, MTHFR A1298C and MTHFR C677T between the study and control groups (p > 0.05). Eight children (14.5 %) had heterozygous and one child (1.8%) had homozygous FVL mutation in the study group. One child (2%) in the control group had heterozygous FVL mutation. There was statistically significant differences of FVL allele and genotype frequencies between the groups (p < 0.05). Conclusions: The prevalence of FVL polymorphism (16.3 %) was higher in ROP patients than control subjects in this Turkish cohort. We suggest a possible association of FVL mutation with ROP at the end of the study.
The status of cadaveric organ donation for liver transplantation in Saudi Arabia.

OBJECTIVE Over the past 2 decades, liver transplantation has became the standard treatment of end stage liver disease. Organ shortage has been the main hindrance against the progress of liver transplantation in the Kingdom of Saudi Arabia. This paper reports the status of organ donation for liver transplantation in the Kingdom of Saudi Arabia and highlights the problems and the suggested solutions in relation to organ shortage. METHODS All donors reported to the liver transplant program at the King Fahad National Guard Hospital, Riyadh, Kingdom of Saudi Arabia, from the Saudi Center of Organ Transplantation from January 1994 through to June 1998 was retrospectively analyzed. Clinical and laboratory data were evaluated to decide on the suitability of organs for liver transplantation. RESULTS Out of 216 donor offers only 100 were harvested and utilized (46%). Out of the remaining 116, 8 donors were declined based on bad clinical and laboratory data and the remaining 36 donors' livers were harvested but not used based on abnormal liver histology. This resulted in discarding more than 50% of the offered donors. The main reasons were related to poor donor maintenance and logistical delay. CONCLUSION The number and quality of organs offered for liver transplantation in the Kingdom of Saudi Arabia over the past 6 years has been deteriorating with a negative impact on the liver transplant programs. Adopting new strategies is required to support the donor program in the Kingdom of Saudi Arabia. It is proposed that establishment of donor promotion offices in major hospitals can change the dismal picture of organ donation in the Kingdom of Saudi Arabia even at the current consent rate by better utilization of the available donors.
Perspectives on death, dying and advance care planning from patients receiving haemodialysis.

BACKGROUND The illness trajectory of End Stage Kidney Disease (ESKD) is not linear therefore it can be difficult for practitioners to know when end-of-life care begins. Advance care planning (ACP) allows patients to take part in decision making, however much of the research conducted stems from North America and Canada where individuals have experience of ACP. The aim of the study was to determine the views of Irish patients receiving haemodialysis, on death, dying and ACP. METHODS A quantitative, descriptive design was used with a convenience sample of 50 patients. Data were collected by means of a researcher administered questionnaire and analysed using descriptive statistics. FINDINGS The majority of participants were comfortable talking about death, but not necessarily among family, with most desiring medical interventions to prolong life. The control of pain and other symptoms, being physically comfortable and being at peace spiritually were the most important issues at end of life. CONCLUSION This study provides an insight into what is important to patients in relation to death, dying and advance care planning.
The effects of exercise on urinary albumin excretion in dogs.

Persistent microalbuminuria has been shown to be an indicator of glomerular damage associated with early progressive renal disease in people and dogs. In people, transient or reversible microalbuminuria has been shown to occur with exercise. A semi-quantitative test to measure microalbuminuria in the dog recently has become available. The purpose of this study was to determine if mild-to-moderate exercise induced microalbuminuria in the dog. Twenty-six dogs were included in the study after undergoing tests to rule out hyperglycemia, urinary tract infection, azotemia, and a urine protein:creatinine ratio >1. Exercise consisted of 20 minutes of flat treadmill running. Urine samples were collected on 2 separate days before exercise, the morning of exercise, 3 hours postexercise, 7-9 hours postexercise, and each of the 2 mornings after exercise. For 24 of 26 dogs, this procedure was repeated after a minimum 7-day interval between exercise sessions. The canine E.R. D. (early renal disease)-Screen Urine Test (E.R.D.-Screen test) was used to determine semiquantitative urine albumin concentrations. Microalbuminuria-positive samples, as determined by the E.R. D. -Screen test, were further analyzed to determine quantitative albumin concentrations. Four (15%) dogs were microalbuminuria positive. In each of these dogs, microalbuminuria was present both before and after exercise with no quantitative increase in urine albumin concentration postexercise. Twenty-two (85%) dogs were microalbuminuria negative throughout the study and did not develop microalbuminuria at any time after exercise. On a 95% confidence interval, the proportion of dogs that might be expected to develop microalbuminuria after exercise is between 0 and 15%.
Effects of Housing and Colostrum Feeding on the Prevalence of Selected Infectious Organisms in Feces of Jersey Calves1

Abstract Neonatal Jersey calves (n=96) were used to evaluate effects of housing (individual hutches or wooden pens in a barn) and colostrum feeding (calves were separated from the dam and fed 2 L of colostrum in nipple-bottles or allowed to nurse the dam for 3 d) on the prevalence of selected organisms in feces. Prevalence of Cryptosporidium and Eimeria were reduced, and prevalence of rotavirus tended to be reduced, when calves were housed in hutches. Prevalence of coronavirus was unaffected by treatment. Weekly prevalence of Giardia was increased when calves were left to nurse the dam for 3 d. Mean prevalence of Cryprosporidia (wk 1 to 4), Eimeria (wk 4 to 5), Giardia, rotavirus, and coronavirus (wk 1 to 5) were 34.7, 20.6, 27.1, 15.8, and 4.9%, respectively. Escherichia coli (K99 positive) were observed in 3 of 174 samples cultured. Methods of housing and colostrum feeding affected acquisition of enteropathogens in this study.
Frequency Controlling Wind Power Modeling of Control Strategies

Conventionally operated full power converter wind plants show high short-term power output variability caused by variable winds, and does not contribute to the power system inertia due to the decoupled generator speed and grid frequency. There is, however, abundant inertial resources in wind plant rotors for both smoothing of output power and for synthetic inertia contribution. Together with added frequency controlling functionality, this could facilitate inclusion of wind power in islanding systems, enabling greater system loads and enhancing power system stability. This paper describes modeling of power smoothing and frequency controlling wind plants and assesses different control strategies as well as the grid frequency performance gains achievable over hydro powered islanding systems and over islanding systems incorporating both hydro power and conventional wind plants. The results show that wind plant power output could be smoothed in the short time frame, and support frequency in both primary and secondary frequency control timescales including droop functionality.
A Single &bgr;-Amino Acid Substitution to Angiotensin II Confers AT2 Receptor Selectivity and Vascular Function

Novel AT2R ligands were designed by substituting individual &bgr;-amino acid in the sequence of the native ligand angiotensin II (Ang II). Relative ATR selectivity and functional vascular assays (in vitro AT2R-mediated vasorelaxation and in vivo vasodepressor action) were determined. In competition binding experiments using either AT1R- or AT2R- transfected HEK-293 cells, only &bgr;-Asp1-Ang II and Ang II fully displaced [125I]-Ang II from AT1R. In contrast, &bgr;-substitutions at each position of Ang II exhibited AT2R affinity, with &bgr;-Tyr4-Ang II and &bgr;-Ile5-Ang II exhibiting ≈1000-fold AT2R selectivity. In mouse aortic rings, &bgr;-Tyr4-Ang II and &bgr;-Ile5-Ang II evoked vasorelaxation that was sensitive to blockade by the AT2R antagonist PD123319 and the nitric oxide synthase inhibitor L-NAME. When tested with a low level of AT1R blockade, &bgr;-Ile5-Ang II (15 pmol/kg per minute IV for 4 hours) reduced blood pressure (BP) in conscious spontaneously hypertensive rats (&bgr;-Ile5-Ang II plus candesartan, −24±4 mm Hg) to a greater extent than candesartan alone (−11±3 mm Hg, n=7, P<0.05), an effect that was abolished by concomitant PD123319 infusion. However, in an identical experimental protocol, &bgr;-Tyr4-Ang II had no influence on BP (n=10), and it was less stable than &bgr;-Ile5-Ang II in plasma stability assays. Thus, this study demonstrated that a single &bgr;-amino acid substitution resulted in a compound that demonstrated both in vitro vasorelaxation and in vivo depressor activity via AT2R. This approach to the design and synthesis of novel AT2R-selective peptidomimetics shows great potential to provide insight into AT2R function.
Distribution of macrophages and plasma cells in apical periodontitis and their relationship with clinical and image data

Background Macrophages and plasma cells play a key role in the regulation of innate and adaptive immunity. The aim of this study was to assess the presence of these cells in apical periodontitis and their distribution comparing with clinical and image data. Material and Methods Thirty-three lesions were selected and divided in two groups (17 periapical cysts and 16 periapical granulomas). Immunoreactions using anti-CD68 and anti-CD138 antibodies were carried out; image analysis was performed with an optical microscope and 5 high-power fields from each slide were evaluated leading to an average score of immunoexpression. This mean score was compared between the two groups and correlated with the clinical and image data. Results There was no statistically significant difference (p >0.05) for the mean average score of CD68+ macrophages and CD138+ plasma cells when comparing the two groups (cysts x granulomas) and the specimens included in each specific group. No statistically significant differences (p >0.05) were also observed when comparing the average scores with clinical and image data. Conclusions The presence of CD68+ macrophages and CD138+ plasma cells was similar in periapical cysts and granulomas and the presence of these cells did not correlate with clinical and image data from both groups. Key words:Macrophages, plasma cells, apical periodontitis, periapical granuloma, periapical cyst.
Do Natural Resource Revenues Hinder Financial Development

We theoretically and empirically examine the relationship between natural resource revenues and financial development. In the theoretical part, we present a politico-economic model in which contract enforcement is low and decreasing in resource revenues when political institutions are poor, but high otherwise. As poor contract enforcement leads to low financial development, the model predicts that resource revenues hinder financial development in countries with poor political institutions, but not in countries with comparatively better political institutions. We test our theoretical predictions systematically using panel data covering the period 1970 to 2005 and 133 countries. Our estimates confirm our theoretical predictions. Our main results hold when we control country fixed effects, time varying common shocks, income and various additional covariates. They are also robust to alternative estimation techniques, various alternative measures of financial development and political institutions, as well as across different samples and data frequencies. We present further evidence using panel data covering the period 1870 to 1940 and 31 countries.