Miracle-dz/UniFAR-FTUs huggingface dataset:
The Birth of Vietnam.

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Having our cake and eating it too: seeking the best of both worlds in expertise research

Context Education researchers in a variety of disciplines have attempted to use their understanding of expert processes to inform learning across the continuum from school learning to lifelong learning. In medical education, this has led to models of expertise that aim to understand accurate and efficient clinical reasoning. More recently, researchers outside medicine have begun to develop models of ‘adaptive expertise’. As these additional constructions of expertise are introduced into health professions education, there is considerable potential to enhance research in medical expertise by providing opportunities for us to identify our implicit assumptions and reflect on the ways in which our theoretical lenses bias our perceptions of what it means to be an expert.
Production of raman laser beams using injection-locking technique

We produced two Raman-laser beams with a frequency offset of 9.2-GHz using a simple injection-locking technique. A slave diode-laser is injection-locked to one f first-order sidebands of a master diode-laser produced by a 9.2 GHz EOM (electro-optic modulator). Using these Raman-laser beams, we observed CPT resonance in a cesium vapor cell.
Identification of a new tadalafil analogue found in a dietary supplement

A new tadalafil analogue, acetaminotadalafil, was detected by HPLC in a bulk powder that is being used as an ingredient formanufacturing dietary supplements. The analogue was isolated by semi-preparative HPLC. A chemical structure of the new compound was elucidated by HPLC, LC-quadrupole time-of-flight mass spectrometry (LC-Q-TOF/MS), nuclear magnetic resonance (NMR), infrared (IR) and circular dichroism (CD) spectroscopy. The compound was identified as an acetylatedcompound of aminotadalafil. The structure of the previous unknown compound was confirmed as (6R,12aR)-2-acetamino-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-pyrazino[1′,2′:1,6]pyrido[3,4-b]indole-1,4-dione and named as acetaminotadalafil.
Gender and the Publication Output of Graduate Students: A Case Study

We examine gender differences among the six PhD student cohorts 2004–2009 at the California Institute of Technology using a new dataset that includes information on trainees and their advisors and enables us to construct detailed measures of teams at the advisor level. We focus on the relationship between graduate student publications and: (1) their gender; (2) the gender of the advisor, (3) the gender pairing between the advisor and the student and (4) the gender composition of the team. We find that female graduate students co-author on average 8.5% fewer papers than men; that students writing with female advisors publish 7.7% more. Of particular note is that gender pairing matters: male students working with female advisors publish 10.0% more than male students working with male advisors; women students working with male advisors publish 8.5% less. There is no difference between the publishing patterns of male students working with male advisors and female students working with female advisors. The results persist and are magnified when we focus on the quality of the published articles, as measured by average Impact Factor, instead of number of articles. We find no evidence that the number of publications relates to the gender composition of the team. Although the gender effects are reasonably modest, past research on processes of positive feedback and cumulative advantage suggest that the difference will grow, not shrink, over the careers of these recent cohorts.
High Prevalence and Incidence of HIV and HCV Among New Injecting Drug Users With a Large Proportion of Migrants—Is Prevention Failing?

ABSTRACT Objectives: The aim of this study was to assess differences in the prevalence of HIV and HCV infection and associated risk factors between new (injecting for ≤5 years) and long-term injectors and to estimate HIV/HCV incidence among new injectors. Methods: Cross-sectional study among people who inject drugs (PWID) who attended harm reduction centers in Catalonia in 2010–11. Anonymous questionnaires and oral fluid samples were collected. Poisson regression models were applied to determine the association between HIV/HCV infection and risk factors. Results: Of the 761 participants, 21.4% were new injectors. New injectors were younger than long-term injectors (mean age = 31.6 vs. 37.8) and were more likely to be immigrants (59.0% vs. 33.4%). HIV and HCV prevalence was 20.6% and 59.4% among new injectors, and estimated HIV and HCV incidence 8.7 and 25.1 /100 person-years, respectively. Among new injectors, HIV infection was associated with homelessness (PR = 3.10) and reporting a previous sexually transmitted infection (PR = 1.79). Reporting front/backloading (PR = 1.33) and daily injection (PR = 1.35) were risk-factors for HCV infection. For long-term injectors, HIV risk factors were: having shared syringes (PR = 1.85), having injected cocaine (PR = 1.38), reporting front/backloading (PR = 1.30) and ever having been in prison (PR = 2.03). Conclusion: A large proportion of PWID in Catalonia are new injectors, a subgroup with a high level of both sexual and parenteral exposure and a high incidence rate of HIV/ HCV infections. It is important to improve early diagnosis of these infections among this group, in particular among migrants. To identify and address risk factors for homelessness PWID should be a priority.
The microbiome and HIV prevention strategies in women

Purpose of review HIV prevention approaches that women can use and control are a priority. Results from topical and oral preexposure prophylaxis (PrEP) HIV prevention trials have produced inconsistent results in women. One of the main behavioural factors impacting effectiveness of PrEP has been suboptimal adherence. In this review, we examine biological factors that modulate topical PrEP efficacy, with particular focus on the vaginal microbiome. Recent findings Genital inflammation is an independent risk factor for HIV acquisition in women. Using 16S rRNA sequencing of the vaginal microbiota, anaerobic bacteria linked with bacterial vaginosis have been shown to be associated with both genital inflammation and HIV risk. Using proteomics, it was recently discovered that a dysbiotic vaginal microbiome, comprising less than 50% Lactobacillus spp. , directly influenced topical PrEP efficacy. Gardnerella vaginalis, the dominant vaginal species in dysbiotic women, was able to directly degrade tenofovir, but not dapivirine, an antiretroviral also being developed for topical PrEP. Summary The link between bacterial vaginosis-associated organisms with HIV risk and altered tenofovir gel effectiveness underscores the importance of good vaginal health and good adherence for women to benefit maximally from topical PrEP. Altering the vaginal microbiome is one of the new directions being pursued for HIV prevention.
The bHLH/PAS factor MOP3 does not participate in hypoxia responses.

The basic helix-loop-helix/PAS (bHLH/PAS) family of proteins regulates transcriptional responses during development and in response to environmental stimuli. bHLH/PAS factors act as heterodimers, and genetic and biochemical data indicate that multiple heterodimeric combinations are found in vivo to regulate hypoxic gene expression. For example, HIF1alpha heterodimerizes with the highly related proteins ARNT or ARNT2 in neurons. In vivo, MOP3 interacts with CLOCK to regulate circadian rhythms; however, its role in hypoxia responses is unclear. We show here that unlike ARNT and ARNT2, MOP3 does not effectively form HIF-1 complexes or restore HIF-1 target gene expression in response to low oxygen when expressed in Arnt(-/-) ES cells. Furthermore, Mop3(-/-) day 9.5 embryos exhibit no angiogenic defects as shown for Arnt(-/-), Hif1alpha(-/-), and Hif2alpha(-/-) embryos. Therefore, by a variety of criteria, we show that MOP3 has little if any role in the regulation of hypoxia responses in vivo.
Dexamethasone eluting electrodes for cochlear implantation: Effect on residual hearing

Abstract Objective The aim of this study was to compare a cochlear implant electrode array loaded with dexamethasone (DXM) with a conventional passive electrode array for the preservation of residual hearing in gerbils. Methods Thirty Mongolian gerbils (Meriones unguiculatus) were implanted with an eluting electrode loaded with DXM (1 and 10%) on one side and a conventional passive electrode on the other side. Hearing thresholds were determined by tone bursts auditory brainstem responses at 4–6 weeks post-implantation and 1-year post-implantation for older gerbils. Results After 4–6 weeks post-implantation, residual hearing was statistically more preserved with electrode arrays loaded with DXM, regardless of concentration, for the frequencies 16 000 Hz (P = 0.0008), 4000 Hz (P = 0.0038), 1000 Hz (P = 0.0349), and 500 Hz (P = 0.0030). After 1 year, the difference in favor of the DXM+ electrode array was found statistically significant only for the frequency 16 000 Hz (P = 0.0103) but against it for the frequencies 1000 Hz (P = 0.0368) and 500 Hz (P = 0.0010). Conclusion Electrode array with prolonged release of DXM improved short-term preservation of residual hearing after implantation for the frequencies 500, 1000, 4000, and 16 000 Hz in gerbils. The long-term results at 1 year confirmed these data for higher frequencies, but must be verified for the lower frequencies of 500 and 1000 Hz.
Acute Effects of Premeal Versus Postmeal Exercise on Postprandial Hypertriglyceridemia

ObjectiveThe objective of this study was to examine the effects of the timing of exercise relative to the consumption of a fat-rich meal (81% fat) on postprandial hypertriglyceridemia. DesignA single bout of exercise was either completed 30 minutes before the fat meal (EM trial) or initiated 90 minutes after the fat meal (ME trial). A third trial, fat meal only, served as a control (CON trial). The trials performed in a random order, and venous blood samples were drawn before and 1.5, 3.5, 5.5, and 7.5 hours after the meal for the determination of triglycerides, glycerol, insulin, glucose, and free fatty acids. ParticipantsTen untrained healthy males 25.2 ± 0.9 years old (mean ± SE) with maximal oxygen uptake (VO2max) of 46.6 ± 3.0 mL · kg−1 · min−1. InterventionWalking exercise performed at 50% VO2max for 90 minutes. Main Outcome MeasurePostprandial hypertriglyceridemia, which was quantified by calculating the area under the triglycerides curve over the 7.5-hour postprandial period. ResultsThe mean incremental area under the curve (total area adjusted to baseline) describing postprandial hypertriglyceridemia was lower both in the EM trial (3.16 ± 0.99 mmol · L−1 · 8 h) and in the ME trial (2.96 ± 0.69 mmol · L−1 · 8 h) compared with CON trial (6.18 ± 1.10 mmol · L−1 · 8 h; P < 0.05). The corresponding areas under the curve describing the postprandial insulinemia were not different between trials (ME: 38.56 ± 8.36 uIU · mL−1 · 8 h; EM: 21.65 ± 3.80 uIU · mL−1 · 8 h; CON: 25.06 ± 5.15 uIU · mL−1 · 8 h; P > 0.05). ConclusionA single bout of moderate intensity exercise decreases postprandial hypertriglyceridemia irrespective of the timing of the exercise relative to a high-fat meal.
Policy, ethics, and reproductive choice: Pregnancy and childbearing among HIV‐infected women

As the numbers of women infected with HIV continue to increase, there are more calls for women who are HIV‐infected not to have children, or for policies to be created that limit or try to influence the reproductive choices of HIV‐infected women. Although motivated by legitimate concerns, such potential policies may be problematic in terms of their threats to the autonomy of women and considerations of justice. An alternative counseling approach is proposed that advocates encouraging HIV‐infected women to make reasoned and considered decisions concerning childbearing. Such an approach would require providers to discuss with women not only the medical facts relevant to vertical transmission, but also many of the psychosocial issues relevant to the woman's interest in bearing a child. Moreover, the encounter would be contextualized to include discussion of issues unique to the woman's situation and other family considerations.
Explaining Growth Differences Across Firms: The Interplay between Innovation and Management Practices

This paper provides first empirical evidence of the joint effects that innovation strategies and human resource management practices exert on firm growth. By exploiting unique information from a large sample of Italian manufacturing companies in the very recent years, it shows that investing in technology and implementing performance-based pay policies are both positively associated with a significant turnover, employment and labor productivity growth premium. However, their joint adoption does not necessarily sum the two effects. In particular, performance-based rewards boost growth of non-innovators and of firms pursuing relatively simple innovation strategies, centered around the acquisition of embodied technology. For firms strongly relying on R&D as an additional lever for product and process upgrading, the estimated effect of having in place monetary incentive mechanisms is null or even negative.
The Sustainable Seafood Movement Is a Governance Concert, with the Audience Playing a Key Role

Private standards, including ecolabels, have been posed as a governance solution for the global fisheries crisis. The conventional logic is that ecolabels meet consumer demand for certified “sustainable” seafood, with “good” players rewarded with price premiums or market share and “bad” players punished by reduced sales. Empirically, however, in the markets where ecolabeling has taken hold, retailers and brands—rather than consumers—are demanding sustainable sourcing, to build and protect their reputation. The aim of this paper is to devise a more accurate logic for understanding the sustainable seafood movement, using a qualitative literature review and reflection on our previous research. We find that replacing the consumer-driven logic with a retailer/brand-driven logic does not go far enough in making research into the sustainable seafood movement more useful. Governance is a “concert” and cannot be adequately explained through individual actor groups. We propose a new logic going beyond consumer- or retailer/brand-driven models, and call on researchers to build on the partial pictures given by studies on prices and willingness-to-pay, investigating more fully the motivations of actors in the sustainable seafood movement, and considering audience beyond the direct consumption of the product in question.
Zr Doped GSO:Ce Single Crystals and Their Scintillation Performance

Cerium doped Gd2SiO5 (GSO:Ce) single crystal is used as a scintillator for positron emission tomography (PET). GSO:Ce has a good balance of every scintillation properties, but the only disadvantage is the decreasing light output by coloring caused by a small amount of Ce4+ in the crystal especially at higher concentration of Ce. In order to improve the scintillation performance, we have tried to grow co-doped GSO:Ce single crystal using conventional starting materials with additional impurities, and evaluate the scintillation performance. Zr doping is found to be effective in preventing coloring and in improving light output. Around 200 ppm Zr doped GSO:Ce have shown maximum light output which is about 20% larger than that of conventional GSO:Ce. This improvement can be explained by the fact that the amount of Ce4+ in the crystal might be changed to Ce3+ due to charge compensation caused by dopant Zr4+ in a Gd3+ site thereby decreasing the light absorption in the crystal
Rapid evolution of seed dispersal in an urban environment in the weed Crepis sancta

Dispersal is a ubiquitous trait in living organisms. Evolutionary theory postulates that the loss or death of propagules during dispersal episodes (cost of dispersal) should select against dispersal. The cost of dispersal is expected to be a strong selective force in fragmented habitats. We analyzed patchy populations of the weed Crepis sancta occupying small patches on sidewalks, around trees planted within the city of Montpellier (South of France), to investigate the recent evolutionary consequences of the cost of dispersal. C. sancta produces both dispersing and nondispersing seeds. First, we showed that, in urban patches, dispersing seeds have a 55% lower chance of settling in their patch compared with nondispersing seeds and, thus, fall on a concrete matrix unsuitable for germination. Second, we showed that the proportion of nondispersing seeds in urban patches measured in a common environment is significantly higher than in surrounding, unfragmented populations. Third, by using a quantitative genetic model, we estimated that the pattern is consistent with short-term evolution that occurs over ≈5–12 generations of selection, which is generated by a high cost of dispersal in urban populations. This study shows that a high cost of dispersal after recent fragmentation causes rapid evolution toward lower dispersal.
A Cautionary Tale of Evaluating Identifying Assumptions: Did Reality TV Really Cause a Decline in Teenage Childbearing?

ABSTRACT Evaluating policy changes that occur everywhere at the same time is difficult because of the lack of a clear counterfactual. Hoping to address this problem, researchers often proxy for differential exposure using some observed characteristic in the pretreatment period. As a cautionary tale of how difficult identification is in such settings, we re-examine the results of an influential paper by Melissa Kearney and Phillip Levine, who found that the MTV program 16 and Pregnant had a substantial impact on teen birth rates. In what amounts to a difference-in-differences approach, they use the pretreatment levels of MTV viewership across media markets as an instrument. We show that controlling for differential time trends in birth rates by a market's pretreatment racial/ethnic composition or unemployment rate causes Kearney and Levine's results to disappear, invalidating the parallel trends assumption necessary for a causal interpretation. Extending the pretreatment period and estimating placebo tests, we find evidence of an “effect” long before 16 and Pregnant started broadcasting. Our results highlight the difficulty of drawing causal inferences from national point-in-time policy changes.
Effect of a Marathon Run on Serum Lipoproteins, Creatine Kinase, and Lactate Dehydrogenase in Recreational Runners

Abstract The objective of this study was to determine the effect of a marathon run on serum lipid and lipoprotein concentrations and serum muscle enzyme activities and follow their recovery after the run. These blood concentrations were measured before, immediately after, and serially after a marathon run in 15 male recreational runners. The triglyceride level was significantly elevated postrace, then fell 30% below baseline 1 day after the run, and returned to baseline after 1 week. Total cholesterol responded less dramatically but with a similar pattern. High-density lipoprotein cholesterol remained significantly elevated and low-density lipoprotein cholesterol was transiently reduced for 3 days after the run. The total cholesterol/high-density cholesterol ratio was significantly lowered for 3 days. Serum lactate dehydrogenase activity significantly doubled postrace and then declined but remained elevated for 2 weeks. Serum creatine kinase activity peaked 24 hr after the run, with a 15-fold rise, and returned to baseline after 1 week. The rise of these enzymes reflects mechanically damaged muscle cells leaking contents into the interstitial fluid. It is concluded that a prolonged strenuous exercise bout in recreational runners, such as a marathon, produces beneficial changes in lipid blood profiles that are significant for only 3 days. However, muscle damage is also evident for 1 week or more from the dramatic and longlasting effect on enzyme levels. Laboratory values for these runners were outside normal ranges for some days after the race.
JP-8 jet fuel exposure potentiates tumor development in two experimental model systems

The US Air Force has implemented the widespread use of JP-8 jet fuel in its operations, although a thorough understanding of its potential effects upon exposed personnel is unclear. Previous work has reported that JP-8 exposure is immunosuppressive. Exposure of mice to JP-8 for 1 h/day resulted in immediate secretion of two immunosuppressive agents; namely, interleukin-10 (IL-10) and prostaglandin E2 (PGE2). Thus, it was of interest to determine if jet fuel exposure might promote tumor growth and metastasis. The syngeneic B16 tumor model was used for these studies. Animals were injected intravenously with tumor cells, and lung colonies were enumerated. Animals were also examined for metastatic spread of the tumor. Mice were either exposed to 1000 mg/m3 JP-8 (1 h/day) for 7 days before tumor injection or were exposed to JP-8 at the time of tumor injection. All animals were killed 17 days after tumor injection. In the present study, JP8 exposure potentiated the growth and metastases of B16 tumors in an animal model. Exposure of mice to JP-8 for 1 h/day before tumor induction resulted in an approximately 8.7-fold increase in tumors, whereas those mice exposed to JP8 at the time of tumor induction had a 5.6-fold increase in tumor numbers. Thus, low concentration JP-8 jet fuel exposures have significant immune suppressive effects on the immune system that can result in increased tumor formation and metastases. We have now extended the observations to an experimental subcutaneous tumor model. JP8 exposure at the time of tumor induction in this model did not affect the growth of the tumor. However, JP8-exposed, tumor-bearing animals died at an accelerated rate as compared with air-exposed, tumor-bearing mice.