Miracle-dz/UniFAR-FTUs huggingface dataset:
Prophylactic and therapeutic strategies in chemotherapy-induced neutropenia

Introduction: Neutropenia poses a serious threat to patients on chemotherapy. It exposes them to the risk of infection – including potentially fatal infections – and also leads to delays in treatment and reductions in dose intensity, which can compromise the possibility of a favorable outcome. Areas covered: The use of granulocyte colony-stimulating factors (G-CSF) and antibiotics to prevent febrile neutropenia (FN) and to ameliorate cancer chemotherapy-induced myelosuppression is discussed, based on a systematic search of Pubmed for clinical trials, reviews and meta-analysis published in the last 20 years. We consider that the treatment of FN, with the emphasis on careful attention to the patient, prompts antibiotic therapy and good hospital care. Expert opinion: We would argue that antibiotic prophylaxis should be offered routinely to patients receiving cytotoxic chemotherapy for acute leukemia and for patients with solid tumors and lymphoma receiving high-dose chemotherapy. In patients undergoing cyclical standard-dose myelosuppressive chemotherapy, we believe that prophylaxis is indicated during the first cycle of chemotherapy in which there is an expectation of grade 4 neutropenia (< 500 neutrophils). However, although the use of antibiotics and haematopoietic growth factors may improve quality of life by reducing the risk and consequences of FN, further study of the magnitude of their effects is needed.
Population Screening for Reproductive Risk for Single Gene Disorders in Australia: Now and the Future

Abstract As the results of the Human Genome Project are realized, it has become technically possible to identify carriers of numerous autosomal and X-linked recessive disorders. Couples at risk of having a child with one of these conditions have a number of reproductive options to avoid having a child with the condition should they wish. In Australia the haemoglobinopathies are the only group of conditions for which population screening is widely offered and which is government funded. In some Australian states there are also population screening programs for cystic fibrosis and autosomal recessive conditions more common in Ashkenazi Jewish individuals which are generally offered on a user pays basis. It is predicted that as consumer demand increases and testing becomes cheaper, that many people planning or in the early stages of pregnancy will have carrier screening for multiple genetic conditions. This will have significant implications for genetic counseling, laboratory and prenatal testing resources. In addition such screening raises a number of ethical issues including the value of lives of those born with genetic conditions for which screening is available.
Sudden Stops of International Fund Flows: Occurrence and Magnitude

Using data of 65 economies from January 2000 (2008) to June 2015, we examine the covariates of sudden stops in fund equity and bond flows. Our results suggest that global, contagion and domestic factors are all related to the likelihood of sudden stops. For sudden stops in equity flows, global factors play a more important role in high‐income economies. For sudden stops in bond flows, global variables are the most important covariates in emerging economies, whereas domestic variables play a more important role in high‐income economies. We also find that global and contagion factors are correlated to the magnitude of sudden stops.
The influence of firm characteristics on profitability

Purpose The purpose of this study is to inspect factors influencing profitability in the Italian hospitality industry during the period 2008-2016. Design/methodology/approach This paper examines the profitability and its determinants using a sample of 2,366 Italian hotels. The author applies a multidimensional measure of profitability comprising return on equity, return on assets, occupancy rate and gross operating profit per available room. The author investigates variables influencing performance and includes them into five groups: market variables, business model, ownership structure, management education and control variables. Findings The results show that financial crisis, business model and ownership structure affect hotel firms’ profitability. Particularly, findings suggest that size, internationalization, location, accommodation as first activity and chain affiliation influence profitability positively. Research limitations/implications Results confirm the importance of firm-specific factors for evaluating the profitability of a hotel firm. Findings also provide new evidence for academics to assess factors that would guarantee profitability of hotels in developed countries such as Italy. Practical implications This investigation offers valued information and strategic suggestions for hotel investors, hotel owners, hotel managers, tourism playmakers and government. Originality/value This paper offers an in-depth examination of the practices and characteristics of profitable hotels in Italy. Few empirical studies examined the determinants of performance in the European and Italian hospitality field so far. Hence, this study attempts to bridge the gap in prior literature on profitability of the Italian hospitality industry.
Angiographic Assessment and Control of Potential Operative Hemorrhage with Pathologic Fractures Secondary to Metastasis

Two cases are reported, which demonstrate the contribution of angiography to the operative management of neoplastic, pathologic fractures. The degree of fracture site neovascularity was assessed by pre-operative arteriography. Selective trans-catheter gelatin-foam embolization was then employed to markedly reduce or obliterate the arterial supply to lesions shown to be richly vascular. Open reduction and internal fixation was subsequently accomplished with minimal operative hemorrhage.
Finite-time fault-tolerant attitude stabilization for spacecraft with actuator saturation

This paper addresses the finite-time fault-tolerant attitude stabilization control problem for a rigid spacecraft in the presence of actuator faults or failures, external disturbances, and modeling uncertainties. First, a basic fault-tolerant controller is proposed to accommodate actuator faults or failures and guarantee local finite-time stability. When there is no a priori knowledge of actuator faults, disturbances, and inertia uncertainties, an online adaptive law is proposed to estimate the bounds of these uncertainties, and local finite-time convergence is achieved by an adaptive fault-tolerant controller. In addition, another adaptive fault-tolerant control scheme is derived that explicitly takes into account the actuator saturation. The proposed attitude controller provides fault-tolerant capability despite control input saturation and ensures that attitude and angular velocity converge to a neighborhood of the origin in finite time. Finally, simulation studies are presented to demonstrate the effectiveness of the proposed method.
Exchange Rate Pass-Through, Nominal Wage Rigidities, and Monetary Policy in a Small Open Economy

This paper discusses the design of monetary policy in a New Keynesian small open economy framework by introducing nominal wage rigidities and incomplete exchange rate pass-through on import prices. Three main findings are summarized. First, with the existence of an incomplete exchange rate pass-through and nominal wage rigidities, the optimal policy is to seek to minimize the output gap, the variance of domestic price and wage inflation, as well as deviations from the law of one price. Second, the CPI inflation targeting Taylor rule is welfare enhancing when there is a technological shock to the economy. The exception occurs when there is a foreign income shock, which minimizes welfare losses under the domestic inflation targeting Taylor rule. Last, two stylized Taylor rules turn out to be a bad approximation, but the modified Taylor rules that respond to the unemployment gap rather than the output gap are a closer approximation to the optimal policy.
Effects of glucose control on arterial stiffness in patients with type 2 diabetes mellitus and hypertension: An observational study

Objective We evaluated the association of glucose control with changes in arterial stiffness, inflammatory markers, and oxidative stress markers. Methods Sixty-four patients with uncontrolled type 2 diabetes mellitus (glycated hemoglobin [HbA1c] ≥ 9%) and hypertension were enrolled in this study. The patients were divided into two groups based on their post-treatment HbA1c level: HbA1c ≤ 7% (well-controlled group, n = 28) and HbA1c > 7% (uncontrolled group, n = 36). The pulse wave velocity, augmentation index, and markers of inflammation and oxidative stress were measured and analyzed. Results The patients’ mean baseline HbA1c level was 11.7%. There were no differences in any baseline parameters between the two groups except the duration of diabetes. The mean HbA1c level was significantly lower at 12 weeks in the well-controlled than uncontrolled group (6.1% vs. 9.0%, respectively), but there were no significant differences in the pulse wave velocity (0.33 ± 0.95 vs. 0.36 ± 1.44 m/s), aortic augmentation index (5.1 ± 8.3 vs. 0.7 ± 11.6), or markers of inflammation and oxidative stress. Conclusions Short-term glycemic control did not influence the arterial stiffness in patients with type 2 diabetes mellitus and hypertension.
Correlates of symptoms of depression and anxiety among clinic patients in western Jamaica.

OBJECTIVES There is a paucity of studies on psychosocial disorders in clinic populations in Jamaica. Therefore, we sought to determine the prevalence and correlates of symptoms of depression and anxiety in a clinic population in western Jamaica. METHODS A total of 338 participants from four outpatient clinics of : A total of 338 participants from four outpatient clinics of the Western Regional Health Authority (WRHA) were screened for symptoms of depression and anxiety using questions from the Beck Depression Inventory-II and the Beck Anxiety Inventory. The Chi-square test was used to examine differences in symptoms of anxiety and depression by gender. Multivariate linear and logistic regression were used to examine the associations between symptoms and sociodemographic variables with significance set at p<0.05. RESULTS Approximately 30% of participants had moderate or severe depression symptoms while 18.6% had moderate or severe anxiety symptoms. Participants aged 30-39 years were more likely than older participants to have moderate or severe anxiety symptoms (odds ratio [OR]: 2.0, 95% confidence interval [CI]: 1.39, 5.56). Women reported a statistically significant higher prevalence of anxiety symptoms (10.0% vs 7.1%, p = 0.003). There was also a statistically significant difference between anxiety means by gender. Furthermore, income was found to be a significant predictor of anxiety for women only (p = 0.0113). Married persons were more likely than those who had never married to have moderate or severe anxiety symptoms (OR: 2.57, 95% CI: 1.14, 5.76). CONCLUSIONS Our findings suggest that the prevalence of depression may be higher than global estimates in similar outpatient settings. Screening and intervention efforts may need to focus on younger persons, women, and married persons.
Gender differences in the prevalence of somatic versus pure depression: a replication.

OBJECTIVE Using data from the Epidemiologic Catchment Area (ECA) study, the author attempted to replicate the finding of the National Comorbidity Survey that the prevalence of depression associated with somatic symptoms was much higher among women than men. METHOD The author reanalyzed data from the ECA study. He divided respondents into those who met criteria for major depression and exhibited appetite and sleep disturbances and fatigue (somatic depression) and those who met depression criteria but did not exhibit all of these somatic criteria (pure depression). RESULTS The reanalysis revealed that the prevalence of somatic depression but not pure depression was much higher among women than men. Somatic depression was associated with high rates of pain; among women, it was associated with high rates of anxiety disorders and chronic dysphoria. CONCLUSIONS The gender difference in depression may result from a difference in a specific type of depression-anxious somatic depression.
Reduced corpus-callosum volume in posttraumatic stress disorder highlights the importance of interhemispheric connectivity for associative memory.

Memory deficits are a common complaint of patients with posttraumatic stress disorder (PTSD). Despite vivid trauma-related memory, previous studies report memory impairment for nontrauma-related stimuli when compared to controls, specifically in associative memory (Guez et al., 2011). Healthy individuals show hemispheric memory asymmetry with left-prefrontal lateralization of encoding and right-prefrontal lateralization of episodic retrieval, suggesting a role for interhemispheric communication in memory-related tasks (Gazzaniga, ; Ringo, Doty, Demeter, & Simard, ). Because brain magnetic resonance imaging (bMRI) studies in PTSD patients report volume changes in various regions, including white matter and corpus callosum (CC), we aimed to test the relationship between memory deficits and CC volume in PTSD patients. We probed for specific alterations in associative memory in PTSD and measured the volume of subportions within the CC employing bMRI. Our main finding was a reduction in CC white-matter volume in PTSD patients, as compared to controls, t(35) = -2.7, p = . 010, that was correlated with lower associative performance (r = .76, p = .003). We propose that CC volume reduction is a substrate for the associative memory deficits found in PTSD.
Halitosis as a product of hepatic disease.

OBJECTIVES This study evaluated halitosis in patients suffering from hepatic disease. MATERIAL AND METHODS Twenty-five patients (12 males and 13 females) aged between 16 and 73 years who had undergone treatment for liver disease were included in this study. Three halimeter recordings were performed to measure methyl mercarptan and hydrogen sulphite. Mean values were calculated and compared with normal values (75-120 ppb). The level of significance was set at P < . 05. Results: Thirteen of the 25 subjects (52%) had normal Volatile Sulphur Compound (VSC) values (75-120 ppb). Twelve subjects (48%) recorded values ranging from 132 to 1112 ppb. There was no correlation between hepatic pathology and halitosis. Fifty-two percent of all subjects had poor oral hygiene, strongly correlated with high VSC values (P<0.05) whereas the remaining 48% with good hygiene had normal levels of VSC. CONCLUSIONS Within the limitations of this study, high values of VSC were not associated with the presence of hepatic disease.
Tying the Extended Family Knot—Grandparents’ Influence on Educational Achievement

In present-day western societies grandparents and grandchildren have longer years of shared lifetime than ever before. We investigate whether children with more grandparent resources have a higher probability of achieving the general secondary degree compared with children with fewer resources, or whether shared lifetime with grandparents increases the probability of achieving the general secondary degree. We use high-quality Finnish Census Panel data and apply sibling random and fixed-effects models that also control for all unobserved factors shared by siblings. Grandparents’ education and socioeconomic status have only a limited ability to explain a grandchild’s educational achievement. However, the sibling fixed-effects models reveal that every shared year between grandparents and grandchildren increases a grandchild’s likelihood of completing general secondary education by 1 percentage point, on average. The effect of shared lifetime is conditional on grandparental type, family resources, and the size of the extended family. Maternal grandmothers have a positive effect on grandchildren’s education in low-income families. Paternal grandmothers provide a link to the resources available through the extended family network, independent of their own resources. The same effects were not observed for grandfathers.
High resolution imaging of endometriosis and ovarian carcinoma with optical coherence tomography: feasibility for laparoscopic‐based imaging

High resolution imaging of gynaecological tissue offers the potential for identifying pathological changes at early stages when interventions are more effective. Optical coherence tomography (OCT) is a high resolution high speed optical imaging technology which is analogous to ultrasound B–mode imaging except reflections of light are detected rather than sound. The OCT technology is capable of being integrated with laparoscopy for real–time subsurface imaging. In this report, the feasibility of OCT for differentiating normal and pathologic laparoscopically–accessible gynaecologic tissue is demonstrated. Differentiation is based on architectural changes of in vitro tissue morphology. OCT has the potential to improve conventional laparoscopy by enabling subsurface imaging near the level of histopathology.
The Changing Nature of Sectoral Comovement

The correlation of output and employment across sectors in the economy -- comovement -- is the defining feature of the business cycle. In this paper, we study how industry comovement patterns in US business cycles have changed over time. We first show that the correlation of output across sectors has fallen since the 1980s, but the correlation of employment across sectors has not. We then build a model featuring input-output linkages in production in both final goods and investment goods which is consistent with these facts. Finally, we use the model to explore the link between changes in comovement patterns across sectors and changes in aggregate dynamics. We find a significant role for comovement in both the decline of GDP volatility and the rise in the volatility of employment relative to output since the 1980s.
Binding of human IgG and F(ab')2 and Fc fragments to cultured trophoblast cells from human term placenta.

Trophoblast cells, dispersed by trypsin digestion of human term placental villi and purified on Percoll gradient, were maintained in serum-containing medium as monolayer cultures up to 7 days. The initially mononucleated cells, probably cytotrophoblasts, differentiated in culture within 90 h to multinucleated syncytiotrophoblast-like cells. The enigmatic binding of human immunoglobulin G (hIgG) to these cells was studied and compared to the well-known binding of hIgG to cultured human monocytes. Binding of hIgG to cultured trophoblasts at 4 degreesC reached steady state by 0.5-1 h, increased about two- to threefold after 90 h in culture and was linear throughout all concentrations tested (0.00067-132 microM). Fc fragments and even F(ab')2 fragments were found to bind to a similar extent to trophoblasts as the complete hIgG molecules. In contrast, in experiments with cultured monocytes, saturation of hIgG binding could be demonstrated. The binding of complete hIgG molecules and of Fc fragments to monocytes was similar whereas binding of F(ab')2 fragments to monocytes was significantly lower. Our results suggest that, despite morphological and at least partially functional differentiation of trophoblast cells in primary culture, no measurable amounts of functional Fc receptor for monomeric hIgG was expressed.
The Effect of Thoracic Paravertebral Blockade on Intercostal Somatosensory Evoked Potentials

The paravertebral nerve blocks used in upper abdominal or thoracic surgery provide excellent pain relief and can inhibit some aspects of the neuroendocrine stress response to surgical trauma, which suggests that a very high-quality afferent block can be effected. To confirm this, we evaluated intercostal somatosensory evoked potentials (SSEPs) in 10 patients undergoing paravertebral nerve blocks as a treatment for chronic pain. SSEPs were recorded before and after ipsilateral thoracic paravertebral deposition of 1.5 mg/kg bupivacaine 0.5%. Sensory loss to temperature was demonstrated in all patients at the level of injection and had a mean superior spread of 1.4 (range 0-4) dermatomes and a mean inferior spread of 2.8 (range 0-7) dermatomes. SSEPs were abolished (the normal waveform was rendered unrecognizable with unmeasurable latencies and a mean amplitude of zero) in all patients at the level of injection. In addition, a two-dermatome SSEP abolition was found in four patients and a three-dermatome abolition was found in two patients. SSEPs were modified, but not significantly, at all other test points. We conclude that cortical responses to thoracic dermatomal stimulation can be abolished at the block level and adjacent dermatomes by thoracic paravertebral nerve blockade. Equivalent results have not been demonstrated with more central forms of afferent blockade, which suggests that thoracic paravertebral nerve blocks may be uniquely effective. Implications: To improve outcomes after major surgery, as much nociceptive information as possible should be prevented from entering the central nervous and neuroendocrine systems. We have shown that local anesthetics alongside the vertebral column can abolish the usual brain recordings that follow intercostal nerve stimulation, which suggests that paravertebral nerve blocks may be uniquely effective. (Anesth Analg 1998;87:373-6)
A Statistical and Geographical Analysis of Workplace Accidents in England and Wales

This research investigates the risk-factors associated with workplace accidents by analysing data generated by Reporting of Injuries, Diseases and Dangerous Occurrences Regulations (RIDDOR), a framework in which the Health and Safety Executive (HSE) collects reports of workplace accidents and injuries. It is reported by the HSE that work-related accidents are a significant problem facing today’s workforce. Unfortunately, however, occupational health and safety have largely been under researched. Little work has previously been carried out surrounding the key determinants of workplace accidents, how these determinants might vary geographically, and whether physical conditions, such as the weather and levels of daylight, might impact levels of occupational health and safety. This research therefore seeks to address these gaps by examining the socio-economic and physical determinants of workplace accidents and injuries, and examines whether the relationships between these risk-factors and accident rates vary geographically and seasonally. Three distinct methods are utilised in analysing the RIDDOR data. These methods include: a global regression analysis based on a set of socio-economic characteristics of workers, a Geographically Weighted Regression analysis of these characteristics on three case study regions: North West England, North East England and London, and text mining, in the form of topic modelling the free-text fields of descriptions of incidents reported under RIDDOR. The key results reveal that age and socio-economic class are influencing factors of workplace accidents. Occupation type is also found to have an effect on workplace accident risk, with workers in low skilled jobs associated with an increased risk of having a work-related injury compared to workers in highly skilled occupations. The relationships between these risk-factors and accident rates have been found to vary geographically, with risk-factors appearing to have a stronger relationship with workplace accidents in particular seasons compared to others. Policy recommendations are formulated to equip the HSE with the knowledge of the key high-risk groups within the workplace population so that preventative measures can be established to reduce the rates of workplace accidents in the future.