Miracle-dz/UniFAR-FTUs huggingface dataset:
Hispanic adolescent delinquency and the family: a discussion of sociocultural influences.

In order to make prevention and intervention services more relevant to Hispanic adolescents and their families, it has been argued that features of the Hispanic culture governing familial relations, primarily familism and family solidarity, need to be emphasized in the treatment of delinquent youth. Yet, analysis of data from a longitudinal survey of 1,077 male Puerto Rican adolescents raises questions as to the precise impact of family experiences on subsequent delinquency involvement, especially as to sociocultural influences of family solidarity and familism. Significance was found only for time spent on weekends and evenings with family members--factors which are not viewed as "cultural. " The impact of spending more time with family members on the weekends and evenings and noninvolvement in delinquent behavior suggest concern with reduction in opportunity for delinquency, especially on weekends and evenings, prime time for delinquent behavior.
Experience of the first breastfeeding session in association with the use of the hands-on approach by healthcare professionals: a population-based Swedish study.

OBJECTIVE The aim of this study was to investigate the prevalence of healthcare professionals' use of the hands-on approach during the first breastfeeding session postpartum and its possible association with the mothers' experience of their first breastfeeding session. MATERIALS AND METHODS This was a population-based longitudinal study conducted at Uppsala University Hospital, Uppsala, Sweden, of all women giving birth at the hospital from May 2006 to June 2007. Six months postpartum, a questionnaire including questions regarding breastfeeding support, caregiving routines, depressive symptoms, and the woman's experience of the first breastfeeding session was sent to the mothers. The main outcome measures were use of the hands-on approach during the first breastfeeding session and the mother's experience of the breastfeeding session. RESULTS In total, 879 women participated in the study. Thirty-eight percent of the women received the hands-on approach during the first breastfeeding session. High body mass index, primiparity, and having the first breastfeeding session postponed were all independently associated with the hands-on approach. Women who received the hands-on approach were more likely to report a negative experience of the first breastfeeding session (odds ratio=4.48; 95% confidence interval, 2.57-7.82), even after adjustment for possible confounders (odds ratio=2.37; 95% confidence interval, 1.02-5.50). CONCLUSIONS This study indicates that the hands-on approach is commonly used during the first breastfeeding session and is associated with a more negative experience of the first breastfeeding session. Consequently, caregivers need to question the use of this method, and further research about breastfeeding support is required.
Phase I Dose-Escalation Study of a Monovalent Heat Shock Protein 70-Herpes Simplex Virus Type 2 (HSV-2) Peptide-Based Vaccine Designed To Prime or Boost CD8 T-Cell Responses in HSV-Naïve and HSV-2-Infected Subjects

ABSTRACT This was a phase I study to assess the safety, tolerability, and immunogenicity of escalating doses of AG-702, a noncovalent complex of an HLA A*0201-restricted epitope in the glycoprotein B protein of herpes simplex virus type 2 (gB2) and truncated human constitutive heat shock protein 70. Similar vaccines have been immunogenic in animals. Three injections of 10 to 250 μg were administered intradermally to HLA A*0201-bearing subjects who were either herpes simplex virus type 2 (HSV-2)-infected or HSV uninfected. Sixty-two participants received the vaccine, 60 completed the protocol, and T-cell data were accrued for 56 subjects. The vaccine was safe and well tolerated. New or boosted responses to the HSV-2 CD8 epitope were not detected. Baseline responses to an epitope in virion proteins 13/14 were higher than responses to the gB2 epitope. A heat shock protein vaccine with an HSV-2 peptide appears to be safe at the doses studied in healthy adults with or without HSV infection. Modifications of the dose, adjuvant, route, schedule, or HSV antigen may be required to improve responses.
Inclusion of additional studies yields different conclusions: Comment on Sedikides, Gaertner, & Vevea (2005), Journal of Personality and Social Psychology

In a Journal of Personality and Social Psychology article, Sedikides, Gaertner and Vevea (2005) presented two meta-analyses that included eight papers to investigate the question of whether people from Eastern cultures self-enhance more for traits that they view to be important compared to those that they view as unimportant. The results supported their hypothesis: Self-enhancement appears to be pancultural. However, this conclusion is severely compromised by six relevant papers that are not included in their meta-analyses. Importantly, all of these six studies contradicted their hypothesis. When complete meta-analyses are conducted which include all of the relevant papers, a very different pattern of results emerges. Eastern and Western cultures do not differ from each other in the pattern of their self-enhancement of independent and interdependent traits. Furthermore, whereas Westerners self-enhanced significantly more for traits that they viewed to be especially important, East Asians did not. Contrary to the Sedikides et al. (2005) suggestion, the existing evidence suggests substantial cross-cultural variation in self-enhancement, with Westerners being far more self-enhancing than Easterners. Reasons for the conflicting pattern of findings across methods and meta-analyses are discussed.
Genetic cardiovascular risk prediction: are we already there?

This editorial refers to ‘Genomic prediction of coronary heart disease’, by G. Abraham et al. , doi:10.1093/eurheartj/ehw450. A key translational promise of contemporary population genetic studies was the opportunity to use the findings to deliver better assessments of human health. However, one of the greatest challenges to such translation has been the realization that the genetic architecture of most chronic diseases is much more complex than originally anticipated1. With few exceptions, an individual’s genetic susceptibility to chronic disease cannot be ascribed to just a few genetic variants. This situation also applies to coronary heart disease (CHD) where dozens of genetic variants with modest effects have been identified to date and where many more variants remain to be uncovered.2,3 One of the most popular approaches to translate knowledge of genetic susceptibility for chronic disease to the clinical arena has been the development and implementation of genetic risk scores (GRSs). A GRS is a single variable that summarizes one’s degree of exposure to many high risk variants. By providing a means to summarize genetic risk, a GRS facilitates the incorporation of this knowledge into existing clinical risk scores allowing one easily to assess the added benefit of such data in a manner similar to any other novel biomarker.4 Many recent studies which have tested GRSs constructed with single nucleotide polymorphisms (SNPs) uncovered by genome-wide association studies (GWASs) of CHD have categorically demonstrated their ability to predict incident CHD outcomes in prospective cohort studies independent of traditional risk factors.4–9 Most of these studies have tested a GRS limited to SNPs that have reached a stringent level of significance for association with CHD in the discovery GWAS.4–9 Intuition dictates that the predictive performance of a GRS should improve as more susceptibility variants are confidently …
Identifying Computer-Supported Collaborative Learning (CSCL) Research in Selected Journals Published from 2003 to 2012: A Content Analysis of Research Topics and Issues

This study aims to identity the emerging research trends in the field of computed-supported collaborative learning (CSCL) so as to provide insights for researchers and educators into research topics and issues for further exploration. This paper analyzed the research topics, methods and technology adoptionof CSCLfrom 2003 to 2012. A total of 706 articles from 9 leading SSCI journals were selected and analyzed through the lens of research topics, research design, research methods, data sources, data analysis methods, research settings, research sample groups, research learning domain, types of collaborative learning, and technology for supporting collaborative learning. The results indicated that technologyin support of collaborative learning, interaction pattern and analysis, CSCL evaluation, and CSCL practice or applications in naturalistic teaching settings and community environment were the four major research topics. Qualitative research approach and descriptive research method were found in most of CSCL publications. Furthermore, it was found that the research topics significantly correlated with the research design and research methods. In the future, researchers and educators should pay more attention to technical affordance and facilitation in collaborative learning.
Two‐year follow‐up of subthalamic deep brain stimulation in Parkinson's disease

We studied 48 patients after bilateral subthalamic nucleus deep brain stimulation (STN‐DBS) who were evaluated 6 months after the surgical procedure using the Unified Parkinson's Disease Rating Scale (UPDRS) in a standardized levodopa test. Additional follow‐up was available in 32 patients after 12 months and in 20 patients after 24 months. At 6 months follow‐up, STN‐DBS reduced the UPDRS motor score by 50.9% compared to baseline. This improvement remained constant at 12 months with 57.5% and at 24 months with 57.3%. Relevant side effects after STN‐DBS included intraoperative subdural hematoma without neurological sequelae (n = 1), minor intracerebral bleeding with slight transient hemiparesis (n = 1), dislocation of impulse generator (n = 2), transient perioperative confusional symptoms (n = 7), psychotic symptoms (n = 2), depression (n = 5), hypomanic behaviour (n = 2), and transient manic psychosis (n = 1). One patient died because of heart failure during the first postoperative year. The current series demonstrates efficacy and safety of STN‐DBS beyond the first year after surgical procedure. Complications of STN‐DBS comprise a wide range of psychiatric adverse events which, however, were temporary. © 2003 Movement Disorder Society
Intra-articular Corticosteroids for Osteoarthritis of the Knee.

Clinical Question Are intra-articular corticosteroids associated with improvement in pain and physical function compared with sham injection or no intervention in patients with knee osteoarthritis? Bottom Line Intra-articular corticosteroids may be associated with moderate improvement in pain and a small improvement in physical function up to 6 weeks after injection. However, the quality of the evidence is low.
Enhanced Differentiation of Human Preosteoblasts on Electrospun Blend Fiber Mats of Polydioxanone and Anionic Sulfated Polysaccharides

The viability and differentiation of SaOS-2 preosteoblasts on fiber mats of blends comprising of the biodegradable poly(ester-ether) polydioxanone (PDX) and the sulfate-containing anionic polysaccharides kappa-carrageenan (KCG) and fucoidan (FUC) were investigated for a range of different blend compositions. The detailed analysis of the blend nanofiber properties revealed a different degree of miscibility of PDX and the polysaccharide leading to a different enrichment at the surface of the blend nanofibers, which were observed to be stable in phosphate buffer solution (PBS) for up to 5 weeks. The fibrous mats of PDX/FUC led to the highest osteogenic differentiation with very good cell viability. The electrospun blend fibers also supported human-induced pluripotent stem (iPS) cells and iPS cell-derived embryoid bodies with high cell viability, which underlines the potential of these novel blend fiber systems for optimized performance in bone tissue engineering applications.
Finding Semantically-Equivalent Binary Code By Synthesizing Adaptors

Independently developed codebases typically contain many segments of code that perform the same or closely related operations (semantic clones). Finding functionally equivalent segments enables applications like replacing a segment by a more efficient or more secure alternative. Such related segments often have different interfaces, so some glue code (an adaptor) is needed to replace one with the other. We present an algorithm that searches for replaceable code segments at the function level by attempting to synthesize an adaptor between them from some family of adaptors; it terminates if it finds no possible adaptor. We implement our technique using (1) concrete adaptor enumeration based on Intel's Pin framework and (2) binary symbolic execution, and explore the relation between size of adaptor search space and total search time. We present examples of applying adaptor synthesis for improving security and efficiency of binary functions, deobfuscating binary functions, and switching between binary implementations of RC4. For large-scale evaluation, we run adaptor synthesis on more than 13,000 function pairs from the Linux C library. Our results confirm that several instances of adaptably equivalent binary functions exist in real-world code, and suggest that these functions can be used to construct cleaner, less buggy, more efficient programs.
4D Model Flow: Precomputed Appearance Alignment for Real‐time 4D Video Interpolation

We introduce the concept of 4D model flow for the precomputed alignment of dynamic surface appearance across 4D video sequences of different motions reconstructed from multi‐view video. Precomputed 4D model flow allows the efficient parametrization of surface appearance from the captured videos, which enables efficient real‐time rendering of interpolated 4D video sequences whilst accurately reproducing visual dynamics, even when using a coarse underlying geometry. We estimate the 4D model flow using an image‐based approach that is guided by available geometry proxies. We propose a novel representation in surface texture space for efficient storage and online parametric interpolation of dynamic appearance. Our 4D model flow overcomes previous requirements for computationally expensive online optical flow computation for data‐driven alignment of dynamic surface appearance by precomputing the appearance alignment. This leads to an efficient rendering technique that enables the online interpolation between 4D videos in real time, from arbitrary viewpoints and with visual quality comparable to the state of the art.
Interlocking Directorate and Firm Performance of Listed Companies in Sri Lanka

Purpose: The purpose of this paper is to investigate the relationship between director interlock and firm performance in Sri Lanka. The author posits that directors gain experiences due to director interlocking which enables them to contribute to the firm performance. On the other hand, busyness of directors due to director interlock destructs the firm performance along with board characteristics. <br><br>Design/Methodology/Approach: Secondary data were obtained from published audited annual reports of 156 companies listed in Colombo Stock Exchange for the period of 2010 to 2017. Ordinary Least squares regression model was used to examine the relationship between director interlocking and firm performance. <br><br>Findings: Empirically, it was found that there is a significant negative association between directors interlocking and firm performance. Further, it was found that, Board size, CEO duality and NED significantly negatively associate with firm performance. The result evidences that NED mere participation on corporate boards within the company would not enhance firm performance. <br><br>Originality/Value: Prior several studies in this nature were performed with develop country data set where this study was emerging market perspective. It may the initial study in Sri Lankan perspective and it could be a tools for evaluate the firm performance.
Paper Electrophoresis of Serum Proteins in Cooley's Anaemia and Sickle Cell Anaemia

The serum proteins of 36 patients with Cooley's major and 12 with sickle cell anaemia were studied by the method of paper electrophoresis. The electrophoretic pattern was almost normal in 9 of 11 infants with Cooley's anaemia aged less than 24 months, while in the remaining two, it was similar to the one observed in the older age group (that is, it showed a decrease in albumin, a slight decrease in α1, α2, and ß‐globulins, and an increase in γ‐globulin).
Canonical transient receptor potential channel 4 (TRPC4) co‐localizes with the scaffolding protein ZO‐1 in human fetal astrocytes in culture

Members of the mammalian transient receptor potential (TRP) family form cation‐permeable channels at the plasma membrane implicated in capacitative calcium influx after activation by either second‐messenger‐mediated pathways or store depletion, or both. This study shows that with the use of RT‐PCR, Western blotting, and immunohistochemistry, resting astrocytes express TRPC4 at the cell membrane, particularly at sites of cell‐to‐cell contact. By confocal imaging and immunoelectron microscopy, we detected co‐localization of TRPC4 with the scaffolding protein zonula occludens 1 (ZO‐1), and demonstrated that immunoprecipitation with antibodies to ZO‐1 brought down TRPC4, and vice‐versa. It has been proposed that the targeting of TRPC4 to the cell membrane is dependent on the interaction of the C‐terminal TRL motif with PDZ domains. Using transfection of astrocytes with myc‐tagged TRPC4 or TRL‐motif truncated TRPC4 (δTRL), we found that δTRL localized predominantly to a juxtanuclear compartment, whereas the wild‐type protein showed cell surface distribution. Deletion of the TRL motif also reduced plasma membrane expression as assessed by cell surface biotinylation experiments. Using GST fusion proteins, we found that TRPC4 interacted with the PDZ1 domain of ZO‐1 and that this was also dependent on the TRL motif. Thus, our data demonstrate that the PDZ‐interacting domain of TRPC4 controls its cell surface localization. These data implicate TRPC4 in the regulation of calcium homeostasis in astrocytes, particularly as part of a signaling complex that forms at junctional sites between astrocytes. © 2004 Wiley‐Liss, Inc.
Observations et modélisation des enveloppes circumstellaires d'étoiles AGB

Les enveloppes circumstellaires autour des geantes rouges s'etablissent pendant de longues periodes qui peuvent durer jusqu'a 10^6 ans. Elles peuvent donc etre etendues (~1pc, peut-etre plus) et nous avons besoin de differents traceurs complementaires pour decrire leurs proprietes globales. Je presente dans cette etude un programme concu pour examiner les proprietes de la matiere dans les parties externes des enveloppes circumstellaires autour d'etoiles de la Branche Asymptotique des Geantes (AGB) et leur liaison avec les enveloppes internes. Je presenterai donc des observations HI a 21 cm ainsi que des observations des transitions rotationnelles de la molecule CO pour plusieurs types d'etoiles. Notre interpretation des profils HI observes est que le vent stellaire est freine par le milieu interstellaire ambiant. Nous avons concu un modele spherique pour tenter de predire cette emission HI, et je discuterai ses resultats. Dans plusieurs cas, l'emission HI est allongee dans une direction compatible avec le mouvement propre de l'etoile, un phenomene qui est observe de plus en plus couramment et qui pourrait de meme s'expliquer dans le cadre d'une interaction avec le milieu local.
Genetic Modification of T Cells Redirected toward CS1 Enhances Eradication of Myeloma Cells

Purpose: Our goal is to test whether CS1 could be targeted by chimeric antigen receptor (CAR) T cells to treat multiple myeloma (MM). Experimental Design: We generated a retroviral construct of a CS1-specific CAR and engineered primary human T cells expressing the CAR. We then tested the capacity of CS1–CAR T cells to eradicate human MM tumor cells in vitro, ex vivo, and in vivo using orthotopic MM xenograft mouse models. Results: In vitro, compared with mock-transduced T cells, upon recognizing CS1-positive MM cells, CS1–CAR-transduced T cells secreted more IFN-γ as well as interleukin (IL)-2, expressed higher levels of the activation marker CD69, showed higher capacity for degranulation, and displayed enhanced cytotoxicity. Ectopically forced expression of CS1 in MM cells with low CS1 expression enhanced recognition and killing by CAR T cells. Ex vivo, CS1–CAR T cells also showed similarly enhanced activities when responding to primary MM cells. More importantly, in orthotopic MM xenograft mouse models, adoptive transfer of human primary T cells expressing CS1–CAR efficiently suppressed the growth of human MM.1S and IM9 myeloma cells and significantly prolonged mouse survival. Conclusions: CS1 is a promising antigen that can be targeted by CAR-expressing T cells for treatment of MM. Clin Cancer Res; 20(15); 3989–4000. ©2014 AACR.
Pengaruh Partisipasi Dalam Penganggaran dan Peran Manajerial Pengelola Keuangan Daerah Terhadap Kinerja Pemerintah Daerah

Factors influencing the performance of local government according to Abdul Halim (2007) are four, namely, entrepreneurial management capacity, organizational culture, macro environment and regional endowment, all of which demand for immediate reinventing local government. Probolinggo District Government performance performance is on performance performance of larger institution when compared with the realization of its expenditure.This study aims to determine the extent of the influence of participation in budgeting and managerial roles of local financial managers to the performance of the local government of Probolingggo.A sample of 82 samples were obtained from questionnaires distributed to 103 respondents consisting of 3 heads of bodies, 11 heads of service, 1 head of inspectorate, 1 secretary of parliament, 8 heads of office, 12 heads of department, 1 director of RSUD, 10 sub-district heads, 25 village heads and 31 principals of kindergarten / junior high / high school / vocational school in Probolinggo district government selected by using purposive sampling method. Of the 103 questionnaires submitted, 85 respondents returned and only 82 questionnaires could be processed and analyzed.The results showed that the high performance of local governments influenced participation in budgeting, meaning that the higher participation in budgeting will increase the performance of local government. The high performance of local government is influenced by the managerial role of regional financial manager means that the higher managerial role of regional finance manager will increase the performance of local government. The results of this study support previous studies and based on the underlying theory of agency theory and prospect theory.