Miracle-dz/UniFAR-FTUs huggingface dataset:
Liver Circulation and Function during Isoflurane and Halothane Anesthesia

Hepatic arterial blood flow (HABF) and portal blood flow (PBF) were measured in 18 dogs while awake and during isoflurane and halothane anesthesia. Surgical preparation 1 week before the measurements consisted of a left thoracotomy, placement of a left atrial catheter, and insertion of another catheter into the distal aorta via the left femoral artery. Cardiac output and liver blood flow were determined using microspheres at three stages: stage 1—awake state; stage 2—after 45 min of 1 MAC of isoflurane (eight dogs) or halothane (10 dogs) anesthesia; and stage 3—after 45 min of 2 MAC of inhalation anesthesia. Half-life and fractional clearance for indocyanine green (ICG) were determined 1 day before the experiment (awake state), and at the end of stages 2 and 3. Mean arterial pressure (MAP) and cardiac index (CI), as well as PBF, decreased during isoflurane and halothane anesthesia. HABF increased significantly during isoflurane anesthesia, remained unchanged during 1 MAC of halothane anesthesia, and significantly decreased during 2 MAC of halothane anesthesia. Apparently, hepatic oxygen supply was maintained much better during isoflurane than during halothane anesthesia. PBF correlated with CI during halothane (r = 0.97) and, to a certain extent, with MAP during isoflurane (r = 0.66). HABF correlated with CI and MAP during halothane (r = 0.74 and 0.71, respectively) but did not correlate with systemic hemodynamic variables during isoflurane. ICG half-life significantly increased during 1 and 2 MAC of halothane anesthesia. The degree of increase did not correlate with the level of anesthesia or the decrease in total hepatic blood flow. Isoflurane anesthesia was not accompanied by significant changes in ICG half-life. The data suggest that halothane has a more deleterious effect on liver blood flow than does isoflurane and, in addition, interferes with liver cell ability to absorb and excrete ICG.
Identification and Characterization of Human Surfactant Protein A Binding Protein of Mycoplasma pneumoniae

ABSTRACT Mycoplasma pneumoniae infections represent a major primary cause of human respiratory diseases, exacerbate other respiratory disorders, and are associated with extrapulmonary pathologies. Cytadherence is a critical step in mycoplasma colonization, aided by a network of mycoplasma adhesins and cytadherence accessory proteins which mediate binding to host cell receptors. Furthermore, the respiratory mucosa is enriched with extracellular matrix components, including surfactant proteins, fibronectin, and mucin, which provide additional in vivo targets for mycoplasma parasitism. In this study we describe interactions between M. pneumoniae and human surfactant protein-A (hSP-A). Initially, we found that viable M. pneumoniae cells bound to immobilized hSP-A in a dose- and calcium (Ca2+)-dependent manner. Mild trypsin treatment of intact mycoplasmas reduced binding markedly (80 to 90%) implicating a surface-associated mycoplasma protein(s). Using hSP-A-coupled Sepharose affinity chromatography and polyacrylamide gel electrophoresis, we identified a 65-kDa hSP-A binding protein of M. pneumoniae. The presence of Ca2+ enhanced binding of the 65-kDa protein to hSP-A, which was reduced by the divalent cation-chelating agent, EDTA. The 65-kDa hSP-A binding protein of M. pneumoniae was identified by sequence analysis as a novel protein (MPN372) possessing a putative S1-like subunit of pertussis toxin at the amino terminus (amino acids 1 to 226), with the remaining amino acids (227 to 591) exhibiting no homology with other subunits of pertussis toxin, other known toxins, or any reported proteins. Recombinant MPN372 (MPN372) bound to hSP-A in a dose-dependent manner, which was markedly reduced by preincubation with mouse recombinant MPN372 antisera. Also, adherence of viable M. pneumoniae cells to hSP-A was inhibited by recombinant MPN372 antisera, demonstrating that MPN372, a previously designated hypothetical protein, is surface exposed and mediates mycoplasma attachment to hSP-A.
Development of an Autonomous Submersible Fish Cage System

A novel and fully automatic rigid fish cage system has recently been developed for deployment in the waters of Korea. The cage structure has 12 sides, incorporating a steel framework with a diameter and depth of 5.92 and 2.91 m, respectively. Attached to the steel framework is a housing for motor valves controlling variable ballast tanks, eight housings for two air compressors, a main control system, four batteries, a reserve air tank, four high air pressure tanks, 12 variable ballast tanks, and a seawater pump housing. The net of the fish cage is tightened across the frame to minimize volume reduction due to currents. The cage is outfitted with a control station located above the valve housing. With the control system, the buoyancy can be adjusted by utilizing compressed air stored in the four high air pressure tanks. The mechanical components of the ballast systems are operated by automated software that incorporates control and monitoring algorithms. The software initiates control of the ballasting components so the fish cage system can submerge if a preselected sea state occurs. The automatic control station incorporates a wind gauge, wireless communication printed circuit boards (PCBs), and a transmitting antenna. During operation, it monitors the wind speed, so the cage can be submerged before extreme sea states and then surfaced after the weather has passed and the conditions are considered safe. The control station also regulates the flow of air and seawater to and from the variable ballast tanks in response to the surface environmental conditions. Control can also be done remotely by a facility operator. In the development process, in situ tests were conducted to assess the performance of the submersion mechanism and the reliability of the automatic control system with a 1/4 size fish cage of similar construction. During the tests, the vertical position and inclination of the fish cage in the water column were measured. During the tests, the close/open states of the motor valves that control the 12 variable ballast tanks were also assessed during descent and ascent operations. The successful performance of the 1/4 size fish cage during the tests showed promise that such a system could possibly be used on a much larger scale to avoid the rigors of the environment in support of commercial level offshore aquaculture.
Competences of Engineers. Evidence from a Comparative Study for Russia and EU countries

Natalia Shmatko - Head, Division for Human Capital Studies, Institute for Statistical Studies and Economics and Knowledge, National Research University - Higher School of Economics. E-mail: nshmatko@hse.ruAddress: National Research University - Higher School of Economics, 20, Myasnitskaya str. , Moscow, 101000.This paper assesses ​​knowledge and skill levels required for engineers in an ideal labor market. Understanding the demand and supply of engineers’ skills is important for modernization policies, and it is also important to know how to measure skill absorption by employees.Based on empirical research, the author evaluates the skill levels and absorption capacities of Russian engineers to measure what knowledge they can mobilize to resolve professional tasks. It constructs profiles of the different categories of engineering personnel. It compares demand and supply of engineering skills in Russia and EU countries in five categories: use of professional knowledge, individual performance, team work, managerial and communication skills.The analysis shows significant distinctions among compared countries. To summarize, the level of general and special competencies for Russian engineers is well below what is required by their workplace. The contrary can be said about their European counterparts, who have the required skills. Serious discrepancies between Russian and European engineers (favouring Europeans) are observed for organization and coordination skills, team work, effective use of time, ability to evaluate critically their own and others’ ideas, use the computer and the Internet for professional purposes.The availability of specialized engineering skills alone is insufficient in today's job market: employers expect a more proactive approach by the engineers, including the promotion of the products. In view of various "distortions" in the training of engineers, not only in Russia but also in other countries, where the patterns of portfolios in the labour market do not match the demand for them, the possession of social skills is of particular value.
towards an organisational team sport intervention model for managing a diverse workforce

The main aim of this study was to develop a diversity management content model based on the organisational team sport intervention and to compile a process model to implement organisational team sport in an organisation in nine financial organisations in Gauteng, South Africa. The diversity constraints relevant in this study were age, gender, race, religious beliefs, physical abilities, ethnicity, generation gaps, sexual orientation, socioeconomic status, physical abilities, education, income, political beliefs and income. The study was conducted among 63 sport participants and nine sport coordinators employed at nine financial organisations in Gauteng, South Africa. The data were collected by means of focus group interviews with sport participants and individual interviews with sport coordinators. The results indicate that organisational team sport interventions as a diversity management initiative do have benefits for the employees (i.e. the employees learn more about and from one another, communicate openly, become friends, trust and respect one another, are able to work together in a team, have equal opportunities and there is less stereotyping/discrimination) and for the organisation (i.e. productivity, the company is able to achieve its goals, employees are more cohesive and able to work together, there is creativity, new ideas are generated and client service improves). The findings of this study contribute valuable new knowledge to the literature on the diversity management content model based on organisational team sport interventions because no studies have been conducted on an organisational team sport intervention model that can be utilised as a diversity model in organisations. KEY TERMS Client service, cohesion, commitment, communication, creativity, diversity, diversity management, friends, goals, new ideas, organisational team sport, productivity, relationships, respect
Analysis of Domains Affecting Intracellular Localization of the FMRP Protein

Fragile X syndrome is the most frequent form of inherited mental retardation and it is caused by deficiency of FMRP, the protein encoded by the FMR1 gene. FMRP is a RNA binding protein of unknown function which is associated with ribosomes. FMRP is found in the cytoplasm, but it is endowed with a nuclear export signal (NES), encoded by exon 14, and a nuclear localization signal (NLS). Characterization of the FMRP NES and NLS domains is presented here. We show by site-directed mutagenesis that three leucine residues in exon 14 are functionally important for the cytoplasmic localization of FMRP. Changing these leucines to serine resulted in a nuclear localization, while another nonconservative change (leucine to tyrosine) did not show such an effect. We also show that the NLS activity is localized between residues 115 and 150, a region that lacks stretches of basic residues. Such stretches are typical of nuclear localization signals that act through the important alpha pathway. The region between residues 151 and 196 can reinforce the NLS activity. A truncated construct containing the N-terminal region of FMRP (residues 1-114) is strikingly concentrated in the nucleus. This suggests that it may contain a domain of strong affinity with a nuclear component.
Inventory Management for Customers with Alternative Lead Times

It is common for suppliers operating in batch‐production mode to deal with patient and impatient customers. This paper considers inventory models in which a supplier provides alternative lead times to its customers: a short or a long lead time. Orders from patient customers can be taken by the supplier and included in the next production cycle, while orders from impatient customers have to be satisfied from the on‐hand inventory. We denote the action to commit one unit of on‐hand inventory to patient or impatient customers as the inventory‐commitment decision, and the initial inventory stocking as the inventory‐replenishment decision. We first characterize the optimal inventory‐commitment policy as a threshold type, and then prove that the optimal inventory‐replenishment policy is a base‐stock type. Then, we extend our analysis to models to consider cases of a multi‐cycle setting, a supply‐capacity constraint, and the on‐line charged inventory‐holding cost. We also evaluate and compare the performances of the optimal inventory‐commitment policy and the inventory‐rationing policy. Finally, to further investigate the benefits and pitfalls of introducing an alternative lead‐time choice, we use the customer‐choice model to study the demand gains and losses, known as demand‐induction and demand‐cannibalization effects, respectively.
Risk, Return, and Performance Measurement: A Case of Unrealistic Expectations?

Client criteria imposed upon active asset management companies to hold only high‐quality (HQ) investments in achieving specific Treasury‐adjusted spreads and above‐average rates of return effectively mandate a passive management policy and can be met only with very low probability. HQ investments do not consistently outperform either medium (MQ) or low quality (LQ) investments over time regardless of whether returns are measured monthly, quarterly, or yearly. Further, both time series and cross‐sectional results show that HQ sectors are generally associated with ex post returns that are lower than those for either MQ or LQ sectors. Finally, HQ sectors do not outperform MQ and LQ sectors in consistently surpassing Treasury spreads or crediting rates. These results suggest that periodic evaluation of asset performance in light of such stringent criteria misunderstands the dynamic nature of the market as well as fundamental risk/return relationships.
Heterogeneous Reactions of Epoxides in Acidic Media Copyright 2011

Heterogeneous Reactions of Epoxides in Acidic Media. (December 2011) Vinita Lal, B.Sc.; M.Sc., Banaras Hindu University, India Chair of Advisory Committee: Dr. Renyi Zhang Epoxides have been recently identified as one of the intermediate species in the gas phase oxidation of alkenes. This study investigates the reaction of isoprene oxide and α-pinene oxide with sulfuric acid to identify the potential of epoxides as important secondary organic aerosol (SOA) precursors. The reaction was explored using different methods to understand the factors governing the reaction rate and the types of products formed under different conditions. Uptake experiments of epoxides on sulfuric acid using Ion drift-Chemical Ionization Mass Spectrometry (ID-CIMS) showed an irreversible uptake of epoxides at room temperature resulting in the formation of less volatile products like diols, organosulfates and acetals. However, at lower temperatures, dehydration of diols and some rearrangement was the preferred reaction pathway resulting in the formation of higher volatility compounds like hydroxy-alkenes and aldehydes. The uptake coefficients of isoprene oxide and α-pinene oxide at room temperature using 96% wt acid were found to be 4×10 and 0.8×10, respectively. Spectroscopic study using Attenuated total reflection-Fourier transform infrared technique (ATR-FTIR) revealed that for both the epoxides, diols were the major identifiable products at low acid concentrations. At higher acid concentrations, acetal formation was observed in case of isoprene oxide, while organosulfate formation was seen for α-pinene
The evaluation of burnout and job satisfaction levels in residents of pediatrics.

AIM The aim of the study was to examine the level of job-related burnout and the level of job satisfaction among residents of pediatrics. MATERIAL AND METHODS A total of 102 residents of pediatrics who were trained in two Ministry of Health teaching and research hospitals and in two university hospitals in Izmir were included in the study. Demographic data (age, sex), lifestyle (living with parents or not, marital status, number of children) and professional characteristics (total time spent in profession, time spent in residency, number of night shifts per month, institution type: teaching hospital/university) were collected. Maslach Burnout Inventory (subscales: emotional exhaustion, desensitization, personal accomplishment) and Minnesota Satisfaction Questionnaire were used. RESULTS High levels of emotional exhaustion and desensitization, and low levels of personal accomplishment and job satisfaction were found in residents of pediatrics. Low levels of emotional exhaustion in teaching and research hospitals and low levels of desensitization in university hospitals were determined (p<0.05). We found a positive correlation between age and job satisfaction levels and a negative correlation between age and emotional exhaustion levels (p<0.05). There were negative correlations between the length of time in education and desensitization and between the number of night shifts per month and desensitization (p<0.05). CONCLUSIONS In residents of pediatrics, there is a high-level burnout and low-level of job satisfaction. Emotional exhaustion is more common in teaching and research hospitals and desensitization is more common in universities. Younger age, lower seniority, and the higher number of work-shift increases the burnout.
Supporting Autonomy to Motivate Patients With Diabetes for Glucose Control

OBJECTIVE We applied the self-determination theory of human motivation to examine whether patient perceptions of autonomy supportiveness (i.e., patient centeredness) from their diabetes care providers related to improved glucose control over a 12-month period. RESEARCH DESIGN AND METHODS We conducted a prospective cohort study of patients with diabetes from a diabetes treatment center at a university-affiliated community hospital. Participants were 128 patients between 18 and 80 years of age who took medication for diabetes, had no other major medical illnesses, and were responsible for monitoring their glucose and taking their medications. The main outcome measure was a change in HbA1c values over the 12 months of the study. RESULTS Patient perception of autonomy support from a health care provider related to a change in HbA1c values at 12 months (P < 0.05). Further analyses showed that perceived autonomy support from the staff related to significant increases in patient autonomous motivation at 12 months (P < 0.05); that increases in autonomous motivation related to significant increases in perceived competence (P < 0.05); and that increases in a patient's perceived competence related to significant reductions in their HbA1c values over 12 months (P < 0.001). CONCLUSIONS The findings support the prediction of the self-determination theory that patients with diabetes whose health care providers are autonomy supportive will become more motivated to regulate their glucose levels, feel more able to regulate their glucose, and show improvements in their HbA1c values.
Forecasting stock prices on the Zimbabwe Stock Exchange (ZSE) using Arima and Arch/Garch models

The main thrust of this study is to find out whether the stock prices on the ZSE can be predicted using ARIMA and ARCH/GARCH models. The ZSE currently does not have a model that predicts stock price movements. Thus this study attempts to explore econometrics models to predict future stock prices on the Zimbabwe Stock Exchange (ZSE) selected counters. Stock price data is differenced and tested for stationarity using KPSS test and the Augmented Dickey Fuller test. The final models are found to be Econet Wireless, ARIMA(1,1,0), Dairiboard, ARIMA(1,1,0), Delta, ARIMA(1,1,1), SeedCo, ARIMA(1,1,1) and Old Mutual, ARIMA(1,1,0). The GARCH(1,1 model for all the counters forecast better than ARIMA models considering the minimum deviations of the forecasted values from the actual ones. This is because the ARCH/GARCH models incorporate new information and analyses the series based on conditional variances where users can forecast future values with up to date information. Old Mutual had the best ARIMA model with the lowest error where as Dairiboard had the best GARCH model as shown by the minimum Schwarz criterion value of 1.365. We conclude that GARCH(1, 1) model outperforms ARIMA models in modeling stock prices in this study.
Hawks, doves, and mixed-symmetry games.

The hawk-dove game has proved to be an important tool for understanding the role of aggression in social interactions. Here, the game is presented in a more general form (GHD) to facilitate analyses of interactions between individuals that may differ in "size", where size is interpreted as a surrogate for resource holding power. Three different situations are considered, based on the availability and use of information that interacting individuals have about their sizes: the classical symmetric case, in which no information about sizes is used, the asymmetric case, in which the individuals know their relative sizes and thus their chances of prevailing in combat, and a mixed-symmetry case, in which each individual only knows its own size (or only knows its opponent's size). I describe and use some recently developed methods for multitype games-evolutionary games involving two or more categories of players. With these methods and others, the evolutionarily stable strategies (ESSs) that emerge for the three different cases are identified and compared. A proof of the form and uniqueness of the ESS for the mixed-symmetry case is presented. In this situation, one size category at most can play a mixed strategy; larger individuals are aggressive and smaller individuals are not. As the number of size categories approaches infinity and the size distribution becomes continuous, there is a threshold size, above which all individuals are aggressive, and below which they are not.
Induced Demand: A Microscopic Perspective

This paper analyses the induced demand hypothesis using a disaggregate approach at the link level. A panel data-set of Minneapolis-Saint Paul highway network for the years 1980-98 is constructed. A model that predicts the traffic flow on the link in terms of vehicle kilometres travelled (VKT) based on the flow and capacity conditions existing on the link in the previous years is specified and estimated. The flow and capacity conditions existing on the identified neighbouring parallel links are also taken into account. Socio-demographic characteristics like population of the Minor Civil Division (MCD) to which the link belongs and the surrounding MCDs are also considered. The results indicate that capacity enhancements in the previous years, given by lane additions, have a positive and significant effect on the VKT of the link, confirming the induced demand hypothesis. The elasticities are lower than reported in previous research, indicating the importance of separating new construction from the expansion of existing links.