Miracle-dz/UniFAR-FTUs huggingface dataset:
Speckle-Tracking echocardiography to assess global and regional left ventricular function in acute myocardial infarction

Speckle tracking is a useful tool in assessing global & regional myocardial function in patients with acute myocardial infarction undergoing primary PCI. Global Longitudinal Strain (GLS) is a robust parameter to assess regional and global LV function. Global longitudinal strain helps in predicting short term outcomes in these patients and has shown to be better than ejection fraction, and as good as wall motion scoring, wall motion scoring index and myocardial performance index. A Lower global longitudinal strain parallels the rise in troponin T and CPKMB in acute myocardial infarction. Global longitudinal strain may have the potential to be an echocardiographic parameter which is useful in identifying multivessel disease. Assessment of regional myocardial function by speckle tracking echocardiography, particularly GLS, can be useful in ACS patients undergoing PCI in predicting short term recovery of the affected segments. Speckle tracking echocardiography can be used independent of the conventional markers to assess regional and global LV function.
The effects of the Lactobacillus acidophilus ATCC 4356 on the oxidative stress of reproductive system in diabetic male rats

Abstract Background Background: Oxidative stress plays an important role in the development of diabetic complications. Objective This study evaluated the impact of pre- and post-treatment with Lactobacillus acidophilus ATCC 4356 on the oxidant and anti-oxidant factors of testis and epididymis in streptozotocin-induced diabetic rats. Materials and Methods Thirty male Wistar rats (10 wk old) weighing 220-230 g. were divided into five groups (n = 6/ each): 1- normal group, 2- normal lactobacillus group, 3- diabetic group, 4- diabetic + lactobacillus before (DLB) group, and 5- diabetic + lactobacillus after (DLA) group. The normal and diabetic groups received daily 1 mL normal saline for 6 wk. Normal lactobacillus group received daily L. acidophilus for 6 wk. Group DLB received daily L. acidophilus for 2 wk before diabetes and for 4 wk after diabetes. Group DLA received daily 1 mL normal saline for 2 wk before diabetes and L. acidophilus for 4 wk after diabetes. The dose of L. acidophilus was 1 × 109 CFU/mL. Results The administration of L. acidophilus worsened blood glucose level and reduced the levels of Malondialdehyde (p ≤ 0.0001) and Hydrogen peroxide (p ≤ 0.0001) and, Catalase and Glutathione peroxidase activity increased in the testis. In epididymis, Glutathione peroxidase and Catalase (p = 0.013) activity increased and Hydrogen peroxide concentration reduced, while Malondialdehyde concentration did not show any changes compared to the diabetic rats. Also, there was no significant difference between DLB and DLA groups, in these markers. Conclusion Data obtained suggests that L. acidophilus has anti-oxidant effects on the testis and sometime in the epididymis in diabetic rats.
Occurrence of antibiotic residues in raw fish Clarias gariepinus and Oreochromis niloticus from intensive rearing system in Benin

An observational cross-sectional study was carriedy out to investigate antibiotic residues in Clarias gariepinus and Oreochromis niloticus from the intensive rearing system in Southern Benin. The targeted antibiotic families were tetracyclins, amphenicols, beta-lactams and macrolides. One hundred and forty-four (144) samples were used per antibiotic family for residue detection in the fish muscle, making 576 treated samples. The Charm II method based on radioimmunoassay was used. The results showed an overall residue prevalence of 11.1%, which is attributable to tetracyclines alone. There was no residue of the other antibiotic families in the treated fish muscles. The adult fish were the only contaminated age group with 22.2% residue prevalence compared to the fingerlings (p < 0.05). Likewise, the antibiotic residues were significantly (p< 0.05) more prevalent in Clarias gariepinus (16.7%) than in Oreochromis niloticus (5.6%). The adult fishes are generally fattier than the young ones, and that can lower the fish body antibiotic elimination capability. This first detection of tetracyclines residues in fish produced in Benin shows the need to rule and control antibiotic use in the developing fish industry to preserve consumers’ health. Keywords: Tilapia, African catfish, fish farm, antibiotic residue, Benin
Contribution of garlic for improving the cytoprotective effect of mesna against cyclophosphamide toxicity in rats

Cyclophosphamide (CYP), an oxazophosphorinealkylating agent, is a widely used drug for treatment of neoplastic and severe autoimmune diseases. Adverse effects of CYP restrict its therapeutic benefits. Mesna (MS), a thiol compound, is used as a protective agent against hemorrhagic cystitis induced by CYP. This study aimed to investigate the potential role of raw garlic homogenate (RGH) for improving the protective effect of mesna against CYP toxicity in rats. Thirty male albino rats were divided into five equal groups. Control group, CYP group (a single i.p. dose, 200 mg/kg b.wt.), CYP+MS group (a total dose of 120 mg/kg b.wt. in three equal doses, i.p.), CYP+RGH group (500 mg/kg b.wt., orally, once daily 5 days before and after CYP injection) and CYP+MS+RGH group. CYP induced hematological changes, including significant reduction of RBCs, Hb, PCV with thrombocytopenia and leukocytopenia. Also, significant increase in serum MDA content concomitantly with significant reduction in TAC was recorded. This was associated with histopathological alterations in the examined tissues. However, mesna and/or garlic improved the recorded hematological, biochemical and histopathological alterations induced by CYP with marked improvement using their combination. In conclusion, garlic supplementation in combination with mesna could be of a great value to introduce therapeutic strategies for patients undertaking cyclophosphamide therapy.
A retrospective, observational, single center study of gonadotropin-releasing hormone agonist protocols at the Reproductive Center of Farah Hospital in Jordan

Background: Data on infertility and in vitro fertilization (IVF) are incomplete and uncertain in Jordan and worldwide because of difficulties in evaluating infertility in the general population. This study aimed at comparing the effectiveness of the gonadotropin-releasing hormone agonists (GnRH-a) long and short protocols as part of IVF or intracytoplasmic sperm injection.Methods: This observational, retrospective, comparative, longitudinal study was conducted in a reproductive center in Jordan. It reviewed data charts from women who took GnRH-a for IVF, from 2010 to 2013. These were categorized in Group A (long-term GnRH-a: single 3.75 mg-monthly injection) or Group B (short-term GnRH-a: multiple daily 0.1 mg injections). The primary endpoint was the rate of ongoing clinical pregnancy (number of pregnancies/number of women) and live birth rate in fresh cycle/protocols.Results: Out of 1,946 eligible women, 471 underwent the long-term treatment of GnRH-a administration and 1,523 the short-term treatment. The women’s mean age was 29.61±3.80 years old. Out of the 471 women in Group A, 216 (45.9%) women had ongoing clinical pregnancy, of whom 69 (31.9%) had live births. In the short-protocol group, 485 (31.8%) women had ongoing clinical pregnancy, of whom 133 (27.4%) had live births.Conclusions: GnRH-a long protocol is more effective than the short protocol regardless of the agonist formulation used in subfertile women/men who underwent IVF/ intracytoplasmic sperm injection.
Nitric Oxide Level Estimation in Patients of Oral Lichen Planus in Kashmiri Population – An Original Research

Introduction: Oxidative stress and antioxidant defense mechanism may play an important role in the pathology of lichen planus. Objectives: Evaluate the levels of NO in serum of patients with OLP and to compare the levels with the controls. Material and Methods: The study included 30 cases of OLP patients which formed the study group and 30 cases of healthy individuals, which formed the controls. Results: The levels of NO were significantly higher in serum of cases with lichen planus than in normal. Conclusion: Serum NO were found to be higher in oral lichen planus patients which suggested that higher serum levels of NO in patients with OLP might activate the process of lymphocytes and cellular immunity system; hence, possibly endorsing the effect of serum NO in pathogenesis of lichen planus.
Gastrointestinal Involvement in Systemic Sclerosis: Overview, Neglected Aspects, Malnutrition, Body Composition and Management

Gastrointestinal tract (GIT) involvement is the most common internal organ manifestation and is present in up to 90% of patients with systemic sclerosis (SSc). Clinical manifestations can differ according to the part of the GIT affected, disease course and symptoms. A majority of the symptoms are caused by GIT dysmotility. Up to 8% of SSc patients develop several GIT symptoms, which increase the mortality. Although GIT involvement is rarely the direct cause of death, it can lead to several comorbidities including malnutrition and negative alterations of body composition. These factors have a negative impact on quality of life and increase the mortality. To date, the treatment is rather symptomatic. The pathogenesis of GIT involvement in SSc still remains to be clarified to improve the treatment approaches including intravenous immunoglobulins and microRNA interventions.
Pengaruh Slow Deep Breathing Terhadap Tekanan Darah Lansia Hipertensi di Puskesmas Ubung Lombok Tengah

Hipertensi menjadi silent killer karena sebagian besar kasus tidak menunjukkan gejala apapun. Hipertensi terus meningkat seiring bertambahnya umur. Penemuan kasus Hipertensi di Puskesmas Ubung meningkat dimana tahun 2016 ditemukan 931 kasus dan tahun 2017 ditemukan 1.240 kasus hipertensi. Lansia yang mengalami hipertensi sebanyak 805 orang. Pengobatan non farmakologi bisa didapatkan dengan melakukan slow deep breathing, selain dengan olahraga atau senam dan mengkonsumsi obat-obatan dapat memberikan keterampilan pada pasien dalam mengatasi tekanan darah pada pasien hipertensi. Tujuan penelitian ini adalah untuk mengetahui pengaruh slow deep brething terhadap tekanan darah lansia hipertensi. Metode: Jenis penelitian ini adalah kuantitatif, metode penelitian Quasy Experiment dengan desain Non Equivalent Control Group. Sampel dalam penelitian ini adalah lansia hipertensi yang mendapat senam. Jumlah sampel dalam penelitian ini adalah 30 orang dengan teknik pengambilan sampel menggunakan purposive sampling. Instrument penelitian menggunakan lembar observasi tekanan darah. Teknik pengolahan data dalam penelitian ini menggunakan uji Paired T-test. Hasil: Hasil Penelitian menunjukkan rata-rata tekanan darah sistol kelompok intervensi sebelum diberi perlakuan sebesar 151,33 mmHg dan diastol sebesar 96,00 mmHg dan sistol kelompok intervensi sesudah diberi perlakuan sebesar 136,00 mmHg dan diastol sebesar 85,33 mmHg dengan nilai signifikansi sistol (ρ value) 0.000 dan diastol (ρ value) 0.000 sehingga Hₒ ditolak. Kesimpulan: Kesimpulan menunjukan adanya pengaruh slow deep breathing terhadap tekanan darah lansia hipertensi di Puskesmas Ubung Lombok Tengah.
Substance P modulates electroacupuncture analgesia in humanized mice with sickle cell disease

Purpose: Chronic pain is a major comorbidity of sickle cell disease (SCD). Acupuncture, a non-opioid and non-addictive therapy to treat pain, was found to reduce pain in the majority (80%) of SCD patients in an earlier retrospective review. We observed that electroacupuncture (EA) decreased hyperalgesia in transgenic mice with SCD with varied analgesia from high to moderate to no response. Interestingly, poor responders exhibited high levels of substance P (SP), a mediator of chronic pain, as well as active p38 MAPK in spinal cords. The present study aimed to investigate the roles of inhibition of SP and SP-activated p38 MAPK in chronic pain in sickle mice that are poorly responsive to EA intervention (moderate/non-responders). Materials and methods: Humanized mouse model with SCD defined as moderate- and non-responders to EA were intraperitoneally administered with antagonist of SP receptor NK1R (netupitant, 10 mg/kg/day, i.p.) or p38 MAPK inhibitor (SB203580, 10 mg/kg/day, i.p.) alone or in combination with EA (acupoint GB30, every 3rd day until day 12). Hyperalgesia to mechanical, thermal and cold stimuli, as well as deep tissue were measured. Phosphorylated p38 MAPK (phospho-p38 MAPK) in the lumbar spinal cord was quantified using western blotting. Phospho-p38 MAPK nuclear translocation in spinal dorsal horn was examined using immunohistochemical staining and confocal microscopy. Results: In EA poor-responders, combined treatment with EA and netupitant signiﬁcantly enhanced the analgesic effects of EA in poor-responders on mechanical, heat, cold, and deep tissue pain, and decreased phosphorylation of p38 MAPK in lumbar spinal cords and its nuclear translocation in the spinal dorsal horn. Furthermore, combined treatment with EA and SB203580 significantly improved analgesic effects of EA on mechanical and heat hyperalgesia, but not cold or deep tissue hyperalgesia. However, additional EA treatment only, or administration of either netupitant or SB203580 alone did not lead to analgesic effects. Conclusions: These results suggest a pivotal role of SP in maintaining the chronic pain in SCD via spinal phospho-p38 MAPK signaling, which may hinder the effect of EA in poor responders. Inhibition of SP signaling pathway or activity of p38 MAPK significantly improved the EA analgesia In EA poor-responders with SCD, which provides a promising way to treat the chronic pain in patients with SCD.
Assessment of sexual dysfunction in females with systemic lupus erythematosus

Introduction Sexual dysfunctions are common sexual health problems affecting a substantial proportion of females with systemic lupus erythematosus (SLE). Objective This study aimed at the evaluation of female sexual dysfunction in patients with SLE. Materials and methods A total of 50 females with SLE and 50 matched healthy female volunteers were assessed using the Arabic version of Female Sexual Function Index. Married and sexually active females during the past 6 months with established diagnosis of SLE were recruited from the Rheumatology Clinic, Beni-Suef University hospital during the period from March to August 2017. All data were statistically analyzed using the IBM statistical package for the social sciences version 20. Results The study showed that 60% of females with SLE and 16% of healthy controls reported abnormal sexual function according to the FSFI total scores, with a statistically significant differences in-between (P=0.00). Conclusion Female sexual dysfunction is a common problem among patients with SLE.
Fetomaternal outcome in caesarean section at full dilatation

Background: To study indications, intraoperative and postoperative complications and fetomaternal outcome in cesarean sections done at full dilatation.Methods: This is a prospective cross-sectional study which was conducted in the department of obstetrics and gynecology, RNT medical college, Udaipur from November 2018 to April 2019. 100 cases of caesarean sections at full dilatation which were performed during this period were analyzed for indications and maternal and fetal morbidity.Results: Among these 100 cesarean sections, majority of cases were in the age group of 21-30 years (46%), booked and Primigravida(81%). Most common indications were cephalo-pelvic disproportion (27%) and fetal distress (21%). Most commonly baby was delivered either by vertex (44%) or by Patwardhan (31%). Intraoperative complications were higher in terms of hematuria in 41%, Atonic PPH in 35%, uterine incision extension in 28% of cases. In one case bladder injury was noticed. Increased incidence of post-operative febrile illness and wound infection were noted. 44% baby’s required nursery admission, most commonly due to birth asphyxia (16%) and RDS (11%). Conclusions: Cesarean section in the 2nd stage of labor is associated with significantly increased maternal morbidity, Neonatal morbidity and mortality. So proper monitoring during labor and involvement of skilled obstetrician in decision making and delivery is crucial to minimize fetomaternal complications.
Comparison of sugammadex and pyridostigmine bromide for reversal of rocuronium-induced neuromuscular blockade in short-term pediatric surgery: a prospective randomized study

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright c the Korean Society of Anesthesiologists, 2019 Comparison of sugammadex and pyridostigmine bromide for reversal of rocuronium-induced neuromuscular blockade in short-term pediatric surgery: a prospective randomized study
Comparing the outcome of septoplasty and septoplasty with turbinectomy in patients with deviated nasal septum

Background: Deviated nasal septum is a bodily disorder results in nasal obstruction. Many surgical procedures are available in correcting the disorder. The present study aimed to compare the surgical outcome of septoplasty alone and septoplasty with turbinectomy in patients with deviated nasal septum.Methods: This prospective study was done on 50 patients attending to the department of ENT of Dr. D. Y. Patil Medical College and Hospital, DPU with complaints of nasal obstruction due to inferior turbinate hypertrophy with deviated nasal septum. The severity of nasal obstruction was assessed by NOSE (nasal obstruction symptom evaluation) scale. Of them, 25 patients were managed with septoplasty alone and other 25 patients with septoplasty and turbinectomy. The outcome of both the procedures was assessed statistically by using NOSE scale. Results: Postoperative symptom improvement was seen in the both groups following surgery (p<0.05). When the NOSE scores are compared between two groups, statistically significant improvement in the symptoms (NOSE score) was seen in the group of patients treated with septoplasty and turbinectomy compared to septoplasty alone (p<0.05). Conclusions: This study re-iterates both septoplasty and concurrent turbinectomy are established mode of treatment in deviated nasal septum along with hypertrophy of inferior turbinates when the preoperative and postoperative symptoms are compared. However, the symptomatic outcomes and diagnostic nasal endoscopic findings are significantly better in patients who underwent septoplasty with concurrent resection of the inferior turbinate.
Evaluation of Early Warning Indicators (EWI) of HIV Drug Resistance According to the World Health Organization (WHO) in Some Treatment Centers in Kinshasa

Background: The Early Warning Indicators (EWI) of Human Immunodefi-ciency Virus (HIV) Drug Resistance measure factors found at the site level and known to be associated with the proper functioning of the program and the prevention of the emergence of R-ARV. The fact strengthening certain aspects of implementation of the program at the sites can help minimize the occurring of HIV Drug Resistance that can be prevented to improve the long-term effectiveness and sustainability of the treatment. Objective: The objective of this study was to assess the quality of the prevention of resistance of HIV Drug compared to EWI set by the World Health Organization (WHO) in the different Ambulatory Treatment Centers (ACT) in the city of Kinshasa. Methods: The present work was a retrospective survey conducted in 2015 in 7 ACTs in the 4 districts of Kinshasa in order to evaluate the EWI. Results: Seven (7) ATCs and 157 patient records were selected based on different inclusion criteria. The maintenance of first-line Antiretroviral Treatment (ART) at 12 months and the consistent delivery of ARVs were the two EWI that were respected, evaluation at 100%, for 6 ACTs. Conclusion: The caregivers and HIV-infected patients should be trained on the EWI and their monitoring to prevent the occurrence of treatment failures and that of HIV drug resistance in Kinshasa.
A study to assess proximal femoral nailing versus dynamic hip screw device in surgical management of intertrochanteric fractures: A comparative study

Background: An inter-trochanteric fracture is a type of hip fracture specifically, which are bony protrusions of femur where the muscles of thigh and hip attach. 50% of all hip fractures caused by falling are inter-trochanteric. Aim: The present study assessed the functional outcomes with DHS and proximal femoral nail (PFN) in inter-trochanteric management of fractures. Materials and Methods: This study was a prospective study which was performed for a period of one year. A total of 40 patients were enrolled during the study. DHS and PFN are the two different implants used for management of intertrochanteric fractures. Results: Functional outcome was better and excellent in PFN (65%) compared to that of DHS (50%). The complications were lesser in Paticipants who were treated by PFN compared to that of participants treated with DHS. Conclusions: Proximal femoral nailing method is preferable method in inter-trochanteric fractures management as it has better functional outcome and lesser complications compared to DHS method.
Prognostic value of preoperative systemic inflammatory response as a prognostic indicator in patients with early-stage oral squamous cell carcinoma

To determine the usefulness of lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and inflammatory response biomarker (IRB) score for predicting disease-specific survival and delayed cervical lymph node metastasis in early-stage oral squamous cell carcinoma (OSCC). We retrospectively analyzed 72 patients with early-stage OSCC. Receiver operating characteristic curve analysis was used to determine the cutoff values for LMR, NLR, and PLR. IRB score was determined as follows: high LMR, high NLR, and low PLR, which were each rated as 1. These scores were added to obtain IRB score (range: 0–3). From univariate analysis, gender, poor mode of invasion, and high IRB score were identified as significant risk factors for disease-specific survival. However, there were no independent factors for poor prognosis in multivariate analysis. On the other hand, for delayed cervical lymph node metastasis, poor mode of invasion, low LMR, high NLR, high PLR, and high IRB score were identified as significant risk factors from univariate analysis, and in multivariate analysis, poor mode of invasion and high IRB score were confirmed as independent risk factors. IRB score and mode of invasion are potentially independent risk factors for delayed cervical lymph node metastasis in early-stage OSCC.