Miracle-dz/UniFAR-FTUs huggingface dataset:
Visual hallucinations: a prevalence study among hospice inpatients

The aim of the study was to determine the prevalence of visual hallucinations among hospice inpatients, and the prevalence of a number of possible associated risk factors. One hundred consecutive admissions to St. John's Hospice in Wirral were screened for visual hallucinations in a semi-structured interview. The prevalence of opioid administration, other drugs known to cause hallucinations, brain tumours, liver metastases, bone metastases, lung metastases, known renal failure, eye disease, Alzheimer's disease, Parkinson's disease, other neurodegenerative disorder, psychiatric disorder and epilepsy were also recorded. Subjects were screened for cognitive function using the Folstein mini-mental state examination (MMSE). Survival times from assessment to death were calculated. The results were analysed using arithmetical means with 95% confidence intervals (Cl) and odds ratios with 95% confidence intervals. Almost half (47%) the patients had experienced visual hallucinations within the previous month. Hypnagogic or hypnopompic hallucinations of a person standing by the bedside were the commonest type. Median survival time for hallucinators was 15 days (range 0–50 days) and for non-hallucinators was 11 days (range 0–89 days). There was no significant difference in cognitive scores between hallucinators and nonhallucinators. Hallucinations were associated with multiple possible risk factors in every case. Hallucinators were more likely to be taking opioids, although the association was not strong (odds ratio 4.48, 95% CI = 1.6–12.19), and were taking larger numbers of potentially hallucinogenic drugs. It is not clear why some patients on opioids hallucinate and others do not. Data on the prevalence of various possible risk factors yielded ample material for the planning of future studies.
A pleiotropic nonadditive model of variation in quantitative traits.

A model of mutation-selection-drift balance incorporating pleiotropic and dominance effects of new mutations on quantitative traits and fitness is investigated and used to predict the amount and nature of genetic variation maintained in segregating populations. The model is based on recent information on the joint distribution of mutant effects on bristle traits and fitness in Drosophila melanogaster from experiments on the accumulation of spontaneous and P element-induced mutations. These experiments suggest a leptokurtic distribution of effects with an intermediate correlation between effects on the trait and fitness. Mutants of large effect tend to be partially recessive while those with smaller effect are on average additive, but apparently with very variable gene action. The model is parameterized with two different sets of information derived from P element insertion and spontaneous mutation data, though the latter are not fully known. They differ in the number of mutations per generation which is assumed to affect the trait. Predictions of the variance maintained for bristle number assuming parameters derived from effects of P element insertions, in which the proportion of mutations with an effect on the trait is small, fit reasonably well with experimental observations. The equilibrium genetic variance is nearly independent of the degree of dominance of new mutations. Heritabilities of between 0.4 and 0.6 are predicted with population sizes from 10(4) to 10(6), and most of the variance for the metric trait in segregating population is due to a small proportion of mutations (about 1% of the total number) with neutral or nearly neutral effects on fitness and intermediate effects on the trait (0.1-0.5 sigma P). (ABSTRACT TRUNCATED AT 250 WORDS)
COMPTON-THICK ACCRETION IN THE LOCAL UNIVERSE

Heavily obscured accretion is believed to represent an important stage in the growth of supermassive black holes and to play an important role in shaping the observed spectrum of the cosmic X-ray background. Hard X-ray (E > 10 keV) selected samples are less affected by absorption than samples selected at lower energies, and are therefore one of the best ways to detect and identify Compton-thick (CT, log N H ≥ 24 ? > ) active galactic nuclei (AGNs). In this letter we present the first results of the largest broadband (0.3–150 keV) X-ray spectral study of hard X-ray selected AGNs to date, focusing on the properties of heavily obscured sources. Our sample includes the 834 AGNs (728 non-blazar, average redshift z ≃ 0.055) reported in the 70-month catalog of the all-sky hard X-ray Swift/Burst Alert Monitor survey. We find 55 CT AGNs, which represent 7.6 − 2.1 + 1.1 % ? > of our non-blazar sample. Of these, 26 are reported as candidate CT AGNs for the first time. We correct for selection bias and derive the intrinsic column density distribution of AGNs in the local universe in two different luminosity ranges. We find a significant decrease in the fraction of obscured Compton-thin AGNs for increasing luminosity, from 46 ± 3% (for log L 14 − 195 ? > = 40–43.7) to 39 ± 3% (for log L 14 − 195 ? > = 43.7–46). A similar trend is also found for CT AGNs. The intrinsic fraction of CT AGNs with log N H ? > = 24–25 normalized to unity in the log N H ? > = 20–25 range is 27 ± 4%, and is consistent with the observed value obtained for AGNs located within 20 Mpc.
Induction of striatal long‐term synaptic depression by moderate frequency activation of cortical afferents in rat

The striatum regulates motor output, and it is thought that changes in the synaptic efficacy of inputs to the striatum contribute to motor learning and habit formation. Previously, several laboratories have observed that brief high frequency stimulation (HFS) of cortical afferents innervating the dorsolateral striatum induces a long‐term decrease in synaptic efficacy called long‐term depression (LTD). We recently showed that HFS‐induced striatal LTD requires retrograde signalling involving postsynaptic release of endocannabinoids and activation of presynaptic CB1 cannabinoid receptors. In the present study we have employed whole‐cell recording in brain slices to examine a new form of LTD at corticostriatal synapses that can be induced by a 10 Hz, 5 min train. The decrease in synaptic efficacy is associated with a decrease in presynaptic release probability, as demonstrated by a decrease in frequency but not amplitude of spontaneous excitatory postsynaptic currents (sEPSCs) and an increase in the paired pulse ratio (PPR). This form of LTD is blocked by antagonists for CB1 and D2 dopamine receptors and impaired by blockers of L‐type calcium channels. However, 10 Hz‐induced LTD does not depend on postsynaptic depolarization, unlike HFS‐induced LTD. Furthermore, this new form of LTD is not prevented by treatments known to block HFS‐induced LTD, including antagonism of metabotropic glutamate receptors (mGluRs), chelation of postsynaptic calcium, or intracellular application of an anandamide membrane transport inhibitor (VDM11). From these findings it is not clear that the endocannabinoid responsible for this form of LTD acts in a retrograde fashion, and the cellular source of endocannabinoid necessary for 10 Hz‐induced LTD is as yet unknown. Our results demonstrate that a prolonged moderate frequency train induces cannabinoid‐dependent LTD, further supporting the idea that endocannabinoids play a prominent role in the regulation of long‐lasting changes in striatal output.
Bipolar II disorder and major depressive disorder: Continuity or discontinuity?

Summary Aim: To find if bipolar II disorder (BPII) and major depressive disorder (MDD) were distinct categories or overlapping syndromes. Methods: 308 BPII and 236 MDD outpatients, presenting for major depressive episode (MDE) treatment, were interviewed with the Structured Clinical Interview for DSM-IV. History of mania and hypomania, and hypomanic symptoms present during MDE, were systematically investigated. Presence of zones of rarity between BPII and MDD depressive syndromes was assessed. Atypical and hypomanic symptoms were chosen because atypical features and depressive mixed state (ie, MDE plus more than 2 concurrent hypomanic symptoms, according to Akiskal and Benazzi 2003) were often reported to distinguish BPII from MDD depressive syndromes (more common in BPII). If BPII were a distinct category, distributions of these symptoms should show zones of rarity between BPII and MDD depressive syndromes. Histograms and Kernel density estimate were used to study distributions of these symptoms. Results: BPII had significantly more atypical features and depressive mixed state than MDD. Histograms and Kernel density estimate curves of distributions of atypical and hypomanic symptoms in the entire sample did not show zones of rarity. Conclusions: Finding no zones of rarity supports a continuity between BPII and MDD (meaning partly overlapping disorders without clear boundaries).
Lattice Boltzmann equation on a two-dimensional rectangular grid

Abstract We construct a multirelaxation lattice Boltzmann model [1] on a two-dimensional rectangular grid. The model is partly inspired by a previous work of Koelman [2] to construct a lattice BGK model on a two-dimensional rectangular grid. The linearized dispersion equation is analyzed to obtain the constraints on the isotropy of the transport coefficients and Galilean invariance for various wave propagations in the model. The linear stability of the model is also studied. The model is numerically tested for three cases: (a) a vortex moving with a constant velocity on a mesh with periodic boundary conditions; (b) Poiseuille flow with an arbitrary inclined angle with respect to the lattice orientation; and (c) a cylinder asymmetrically placed in a channel. The numerical results of these tests are compared with either analytic solutions or the results obtained by other methods. Satisfactory results are obtained for the numerical simulations.
Umbilical Cord‐Derived Mesenchymal Stem Cells With Forced Expression of Hepatocyte Growth Factor Enhance Remyelination and Functional Recovery in a Rat Intracerebral Hemorrhage Model

BACKGROUNDSpontaneous intracerebral hemorrhage (ICH) carries a high mortality rate, with survivors commonly left with permanent neurological deficits. Mesenchymal stem cell (MSC) transplantation promotes functional recovery in experimental ICH, and treatment with hepatocyte growth factor (HGF) is beneficial in ischemic stroke. OBJECTIVEWe hypothesize that transplantation of MSCs with previous transduction of HGF has an additive effect in promoting neurological recovery through myelin and axonal regeneration. METHODSHGF transduction to human umbilical cord-derived MSCs using lentiviral plasmid pWPI-HGF-GFP was prepared. One week after a collagenase-induced ICH, 80 male Sprague-Dawley rats were divided into 3 groups for stereotactic injection of phosphate-buffered saline (group I), MSC transplant (group II), and HGF-transduced MSC transplant (group III), respectively, into the left ventricle. The animals were assessed weekly for 5 weeks using the Rotarod motor function test, at which time they were killed for Luxol fast blue myelin staining and appropriate immunohistochemistry and Western blotting. RESULTSAnimals receiving transplanted HGF-transduced MSCs (group III) exhibited significantly better motor function recovery than animals treated with MSCs alone (group II), which in turn performed better than the phosphate-buffered saline controls at 2 weeks after transplantation. Luxol fast blue staining of myelin displayed significantly less demyelination and significantly higher reactivity in myelin basic protein and growth-associated protein-43 in immunohistochemistry and Western blotting and significantly reduced myelin-associated glycoprotein activity in group III animals. CONCLUSIONAnimals transplanted with HGF-transduced MSCs 1 week after experimental ICH were shown to achieve a better neurological recovery. This improved neurological recovery from ICH is attributed to nerve fiber remyelination and axonal regeneration.
The Role and Perceptions of Middle Managers and Their Influence on Business Performance: The Case of Sri Lanka

This paper investigates the role and perceptions of middle managers and how they influence business performance in Sri Lankan companies. The study presented here is based on a questionnaire survey of 121 middle managers regarding issues of communication, group decision making, and organizational leadership. Quantitative analysis of the responses suggests that organizations with collectivistic leaders achieve better performance. As a result, it is argued that collectivism, which includes middle management, can positively contribute to Sri Lanka’s business development and economic recovery.
Improving Diagnosis in Health Care.

Getting the right diagnosis is a key aspect of health care it provides an explanation of a patient's health problem and informs subsequent health care decisions. The diagnostic process is a complex, collaborative activity that involves clinical reasoning and information gathering to determine a patient's health problem. According to Improving Diagnosis in Health Care, diagnostic errors-inaccurate or delayed diagnoses-persist throughout all settings of care and continue to harm an unacceptable number of patients. It is likely that most people will experience at least one diagnostic error in their lifetime, sometimes with devastating consequences. Diagnostic errors may cause harm to patients by preventing or delaying appropriate treatment, providing unnecessary or harmful treatment, or resulting in psychological or financial repercussions. The committee concluded that improving the diagnostic process is not only possible, but also represents a moral, professional, and public health imperative. Improving Diagnosis in Health Care a continuation of the landmark Institute of Medicine reports To Err Is Human (2000) and Crossing the Quality Chasm (2001) finds that diagnosis-and, in particular, the occurrence of diagnostic errorsâ€"has been largely unappreciated in efforts to improve the quality and safety of health care. Without a dedicated focus on improving diagnosis, diagnostic errors will likely worsen as the delivery of health care and the diagnostic process continue to increase in complexity. Just as the diagnostic process is a collaborative activity, improving diagnosis will require collaboration and a widespread commitment to change among health care professionals, health care organizations, patients and their families, researchers, and policy makers. The recommendations of Improving Diagnosis in Health Care contribute to the growing momentum for change in this crucial area of health care quality and safety.
Pregnancy outcomes from in-vitro fertilisation and intracytoplasmic sperm injection: a comparison.

INTRODUCTION The purpose of this study was to compare the obstetrical course of in-vitro fertilisation pregnancies with and without intracytoplasmic sperm injection, and to ascertain any difference in the outcome. Both singleton and multiple pregnancies were assessed individually in areas where they could confound results. METHODS This was a retrospective analysis of all successful in-vitro fertilisation pregnancies at the Singapore General Hospital during the period 1998-2003. A total of 271 pregnancies with and without intracytoplasmic sperm injection were evaluated. The details of the pregnancies were obtained from the Assisted Reproductive Technology Registry and Birth Defects Registry. RESULTS The obstetrical outcome was comparable between the two groups, in terms of the number of deliveries, biochemical and ectopic pregnancies. There was no significant difference in the miscarriage rate. The preterm rates for an intracytoplasmic injection pregnancy were two times higher than that reported in literature for both singletons and multiple pregnancies. The singleton intracytoplasmic sperm injection pregnancies were more likely to deliver preterm (17.5 percent, p-value is 0.041) compared to the ones without intracytoplasmic injection (5.7 percent). The average singleton birth weight was lower for the former (2.94 [+/-0.53] kg) than for the latter (3.19 [+/-0.48] kg, p-value is 0.0173). No definite conclusion could be reached regarding the differences in congenital abnormalities between the two groups. CONCLUSION The obstetrical course of an in-vitro fertilisation pregnancy with intracytoplasmic sperm injection pregnancy appears to be similar to one without intracytoplasmic sperm injection except for a slight increase in the preterm deliveries and a lower birth weight at delivery among the singletons.
The influence of product aesthetics and user state in usability testing

An empirical study examined the effects of two influencing factors in usability tests on user performance and usability ratings. Product aesthetics (high vs. low) as the main independent factor and prior usage event (positive vs. negative) as a subsidiary independent factor were varied in a between-participants design. 60 participants took part in the experiment, completing a number of typical tasks of mobile phone users. The results showed that increased product aesthetics had a positive effect on perceived usability and led to longer task completion times. After a negative usage event had been experimentally induced, usability ratings dropped as expected but user performance on subsequent tasks remained unaffected. An important implication of the study is that the aesthetic properties of a product may have multiple effects that go beyond perceived product attractiveness.
Obesity Increases Prevalence of Colonic Adenomas at Screening Colonoscopy: A Canadian Community-Based Study

Background and Aims Obesity is a risk factor for colorectal neoplasia. We examined the influence of obesity and metabolic syndrome (MetS) on prevalence of neoplasia at screening colonoscopy. Methods We evaluated 2020 subjects undergoing first screening colonoscopy. Body mass index (BMI) was calculated at enrolment. Hyperlipidemia (HL), hypertension (HT), and diabetes mellitus (DM) were identified. Details of colonoscopy, polypectomy, and histology were recorded. Odds for adenomas (A) and advanced adenomas (ADV) in overweight (BMI 25.1–30) and obese (BMI > 30) subjects were assessed by multinomial regression, adjusted for covariates. Analyses included relationships between HL, HT, DM, age, tobacco usage, and neoplasia. Discriminatory power of HT, HL, DM, and BMI for neoplasia was assessed by binary logistic regression. Odds were calculated for neoplasia in each colonic segment related to BMI. Results A and ADV were commoner in overweight and obese males, obese females, older subjects, and smokers. HL, HT, and DM were associated with increased odds for neoplasia, significantly for A with hypertension. BMI alone predicted neoplasia as well as HT, HL, DM, or combinations thereof. All segments of the colon were affected. Multiple polyps were particularly prevalent in the obese. Conclusions Obesity and MetS are risk factors for colonic neoplasia in a Canadian population.
Randomization Approaches for Network Revenue Management with Customer Choice Behavior

In this study, we present new approximation methods for the network revenue management problem with customer choice behavior. Our methods are sampling‐based and so can handle fairly general customer choice models. The starting point for our methods is a dynamic program that allows randomization. An attractive feature of this dynamic program is that the size of its action space is linear in the number of itineraries, as opposed to exponential. It turns out that this dynamic program has a structure that is similar to the dynamic program for the network revenue management problem under the so called independent demand setting. Our approximation methods exploit this similarity and build on ideas developed for the independent demand setting. We present two approximation methods. The first one is based on relaxing the flight leg capacity constraints using Lagrange multipliers, whereas the second method involves solving a perfect hindsight relaxation problem. We show that both methods yield upper bounds on the optimal expected total revenue. Computational experiments demonstrate the tractability of our methods and indicate that they can generate tighter upper bounds and higher expected revenues when compared with the standard deterministic linear program that appears in the literature.
Altered T cell activation and development in transgenic mice expressing the HIV‐1 nef gene.

The nef gene, which encodes related cytoplasmic proteins in both human (HIV) and simian (SIV) immunodeficiency viruses is dispensable for viral replication in vitro. In contrast, in vivo experiments have revealed that SIV nef is required for efficient viral replication and development of AIDS in SIV infected rhesus monkeys, thus indicating that nef plays an essential role in the natural infection. We show that expression of the Nef protein from the HIV‐1 NL43 isolate in transgenic mice perturbs development of CD4+ T cells in the thymus and elicits depletion of peripheral CD4+ T cells. Thymic T cells expressing NL43 Nef show altered activation responses. In contrast, Nef protein of the HIV‐1 HxB3 isolate does not have an overt effect on T cells when expressed in transgenic animals. The differential effects of the two HIV‐1 nef alleles in transgenic mice correlate with down‐regulation of CD4 antigen expression on thymic T cells. The differential interactions of the NL43 and HxB3 nef alleles with CD4 were reproduced in a transient assay in human CD4+ CEM T cells. Down‐regulation of CD4 by nef in both human and transgenic murine T cells indicates that the relevant interactions are conserved in these two systems and suggests that the consequences of Nef expression on the host cell function can be analyzed in vivo in the murine system. Our observations from transgenic mice suggest that nef‐elicited perturbations in T cell signalling play an important role in the viral life cycle in vivo, perhaps resulting in elimination of infected CD4+ T cells.
Combined biliary and gastric bypass procedures as effective palliation for unresectable malignant disease

Background: Although endoscopic treatment of jaundice is increasingly used in the palliation of unresectable malignant disease, surgical bypass still has a role to play in this setting. This study aimed to reappraise the short‐term and long‐term results of combined biliary/gastric bypass (hepaticojejunostomy and gastrojejunostomy) as palliation for unresectable malignant disease.