Miracle-dz/UniFAR-FTUs huggingface dataset:
Synchronization and state estimation of nonlinear physical systems under communication constraints

An exposition of the results on synchronization and state estimation of nonlinear systems over the limitedband communication channel is given. Relevance of passifiability condition for controlled synchronization of master-slave nonlinear systems for first order and full-order coder/decoder pairs is demonstrated. The algorithm for state estimation of spatially distributed systems based on the local measurements and quantization of the transmitted data is developed, and its limit opportunities are studied. The numerical and experimental results for various physical systems are described, demonstrating practical applicability of the theoretical statements and high efficiency of the proposed estimation and synchronization schemes.
SEQUENCE STRUCTURE IS REFLECTED IN DYNAMIC NEURAL RESPONSES

Background. It is a commonplace notion that melodies are tone sequences which are neither too random nor too predictable in their structure. Little is known, however, about patterns of brain response as a function of the structure of tone sequences. Aims. This study sought to determine if differences in the statistical structure of tone sequences are reflected in measurable, dynamic neural responses, and if sequences that are melody-like in their statistical properties have a distinct neural signature. Methods. Subjects listened to 1-minute long diatonic tone sequences while neural signals were recorded using 148channel whole-head magnetoencephalography (MEG). Sequences were random, deterministic (scalar), or one of two categories of 'fractal' sequences differing in their balance of predictability and unpredictability. (One of the fractal categories had melody-like statistics). Amplitudemodulation of the tone sequences was used to generate an ongoing, identifiable neural response whose amplitude and timing (phase) could be studied as a function of sequence structure. Results. Ongoing timing patterns in the neural signal showed a strong dependency on the structure of the tone sequence. At certain sensor locations, timing patterns covaried with the pitch contour of the tone sequences, with increasingly accurate tracking as sequences became more predictable. In contrast, interactions between brain regions (as measured by temporal synchronization), particularly between left posterior regions and the rest of the brain, were greatest for the tone sequences with melody-like statistics. This may reflect the perceptual integration of local and global pitch patterns in melodylike sequences. Conclusions. Dynamic neural responses reveal a neural correlate of pitch contour in the human brain, and show that interactions between brain regions are greatest when tone sequences have melody-like statistical properties.
Morbidity and mortality attributable to alcohol, tobacco, and illicit drug use in Canada.

OBJECTIVES This study estimated morbidity and mortality attributable to substance abuse in Canada. METHODS Pooled estimates of relative risk were used to calculate etiologic fractions by age, gender, and province for 91 causes of disease or death attributable to alcohol, tobacco, or illicit drugs. RESULTS There were 33,498 deaths and 208,095 hospitalizations attributed to tobacco, 6701 deaths and 86,076 hospitalizations due to alcohol, and 732 deaths and 7095 hospitalizations due to illicit drugs in 1992. CONCLUSIONS Substance abuse exacts a considerable toll on Canadian society in terms of morbidity and mortality, accounting for 21% of deaths, 23% of years of potential life lost, and 8% of hospitalizations.
[Treatment of pancreatic pseudocysts by laparoscopic cystogastrostomy].

AIM To evaluate the clinical results of laparoscopic cystogastrostomy and to determine the potential advantages of this new therapeutic option. PATIENTS AND METHODS This study concerned 12 patients presenting with pancreatic pseudocyst and operated on by laparoscopic cystogastrostomy between 1997 and 2002. There were five men and seven women with a median age of 46 years (range: 30-72). In ten patients, the pseudocyst developed after acute pancreatitis and the median delay between the acute onset and surgery was 7 months (range: 2-24). In two patients, the pseudocyst was associated with chronic pancreatitis. All the patients had a single cyst bulging into the posterior wall of the stomach and the median cyst diameter was 9 cm (range: 5-14). RESULTS Endoluminal gastric laparoscopy was used in six patients and intraperitoneal transgastric laparoscopy in six patients. Conversion to open surgery was required in one patient because the cyst could not be correctly localised by laparoscopy. The median size of the cystogastrostomy was 3 cm (range: 2-5). In eight patients, necrotic debris were still present within the cyst. The median operative time was 90 min (range: 60-140) and the median postoperative hospital stay was 6 days (range: 4-24). No mortality was recorded and postoperative morbidity was limited to one haematoma of the rectus sheath on a port site. One patient was readmitted on the 20th postoperative day because of cyst infection due to partial closure of the cystogastrostomy and was treated by endoscopic placement of a stent. One patient was lost for follow-up 2 months after surgery. With a median clinical and radiological follow-up of 12 months (range: 6-36), no recurrence of pancreatic pseudocyst was observed. CONCLUSIONS In this series, laparoscopic cystogastrostomy is associated with a low postoperative morbidity and an effective permanent result. Laparoscopy has two main advantages: an excellent control of haemostasis and the creation of a wide communication with debridement of the cyst contents thus minimizing the risk of infection or recurrence of the pseudocyst.
Off-Label Use of Crizotinib as a Neoadjuvant Treatment for a Young Patient When Conventional Chemotherapy Gave No Benefits in Stage IIIA Non-Small Cell Lung Cancer

Patient: Male, 37 Final Diagnosis: Lung adenocarcinoma Symptoms: Cough Medication: — Clinical Procedure: — Specialty: Oncology Objective: Unusual setting of medical care Background: The treatment of locally advanced non-small cell lung cancer involves a combination of chemotherapy, surgery, and radiotherapy. Each case is discussed and the best strategy is chosen individually, following international guidelines. Case Report: A 37-year-old man was diagnosed with locally advanced broncho-pulmonary adenocarcinoma (stage IIIA). The disease was stable after 2 cycles of cisplatin plus Navelbine used as neoadjuvant therapy. FISH analysis revealed an ALK rearrangement. The patient then received unlicensed crizotinib as second-line neoadjuvant treatment, which led to an almost complete radiological and metabolic response. A left upper lobectomy was performed, followed by post-operative chemotherapy and radiotherapy. At 18 months post-surgery, the patient is still disease-free according to the last CT scan. Conclusions: Targeted therapy was an alternative solution when chemotherapy was not helping. Randomized studies are needed to define its precise role in the neoadjuvant scheme.
IL-21 and BAFF/BLyS Synergize in Stimulating Plasma Cell Differentiation from a Unique Population of Human Splenic Memory B Cells1

Both constitutive Ig secretion by long-lived plasma cells (PC) and the recurrent differentiation of memory (mem) B cells into PC contribute to the maintenance of serologic mem. However, the relative contribution of each is unknown. In this study, we describe a novel population of human postswitched mem B cells that rapidly differentiate into PC and thus contribute to serologic mem. These IgG+ B cells reside in the region of human spleen analogous to the murine marginal zone and have not previously been examined. These cells are highly responsive to IL-21 in the context of CD40 stimulation. Uniquely, IgG+ marginal zone analog B cells are exquisitely sensitive to the combination of IL-21 and B cell-activating factor belonging to the TNF family (BAFF/BLyS) that synergize in the absence of further costimulation to induce up-regulation of B lymphocyte-induced maturation protein-1 and drive PC differentiation. Other cytokine combinations are not active in this regard. This is the first demonstration that this unique population of mem B cells can respond specifically and exclusively to IL-21 and BAFF/BLyS by differentiating into IgG-secreting PC, and thus contributing to serologic mem in an Ag-independent manner.
Understanding User Responses to Information Technology: A Coping Model of User Adaption

This paper defines user adaptation as the cognitive and behavioral efforts performed by users to cope with significant information technology events that occur in their work environment. Drawing on coping theory, we posit that users choose different adaptation strategies based on a combination of primary appraisal (i.e., a user's assessment of the expected consequences of an IT event) and secondary appraisal (i.e., a user's assessment of his/her control over the situation). On that basis, we identify four adaptation strategies (benefits maximizing, benefits satisficing, disturbance handling, and self-preservation) which are hypothesized to result in three different individual-level outcomes: restoring emotional stability, minimizing the perceived threats of the technology, and improving user effectiveness and efficiency. A study of the adaptation behaviors of six account managers in two large North American banks provides preliminary support for our model. By explaining adaptation patterns based on users' initial appraisal and subsequent responses to an IT event, our model offers predictive power while retaining an agency view of user adaptation. Also, by focusing on user cognitive and behavioral adaptation responses related to the technology, the work system, and the self, our model accounts for a wide range of user behaviors such as technology appropriation, avoidance, and resistance.
Corneal grafting for the treatment of feline corneal sequestrum: a retrospective study of 18 eyes (13 cats).

OBJECTIVE To determine the clinical outcome of corneal grafting for the treatment of feline corneal sequestrum (FCS). ANIMAL STUDIED Domestic cats. PROCEDURES A review of the medical records of cats that underwent keratoplasty as a treatment of FCS at the VTH-UAB, from 2002 to 2012, was carried out. RESULTS Thirteen cats (18 eyes) of different breed, age, and gender were included. Persian cats were overrepresented (12/13;92%). There were nine males and four females, of a mean age of 3.4 years (0.7-7.1). Ipsilateral chronic corneal ulceration was reported as the most common concurrent ocular disease (6/18;33%). Keratoplasty was performed bilaterally in 5 cats (5/13;38%) and unilaterally in 8 (8/13;62%). Lamellar keratoplasty was performed in 17 eyes (17/18;95%) and full-thickness keratoplasty in 1 (1/18;5%). Mean graft size was 8.3 mm (4-11.5). Fresh homologous graft was performed in 2 eyes (2/18;11%) and frozen graft in 16 (16/18;89%). Of the latter group, homologous graft was performed in 6 eyes (6/16;37.5%) and heterologous in 10 (10/16;62.5%). In all the cats, postoperative treatment included topical antibiotics, corticosteroids, cycloplegics, and 0.2% cyclosporine A. Median follow-up time was 18.2 months, and main postoperative complications were diffuse mild epithelial pigment formation (2/18;11%), graft malacia (1/18;5%), and sequestrum recurrence (1/18;5%). Mean epithelial healing time was 19.2 days. Good visual outcome was achieved in all the eyes (100%), the majority of them having faint or mild corneal opacity (15/18;83%). CONCLUSIONS Keratoplasty is an effective surgical treatment for FCS. The donor tissue provides excellent tectonic support to the affected corneas, with good visual and cosmetic outcome.
Rapid Detection of Carbapenemase Production in Enterobacteriaceae by Use of a Modified Paper Strip Carba NP Method

ABSTRACT Rapid and accurate detection of carbapenemase-producing Enterobacteriaceae (CPE) is important for preventing their spread in health care settings. We compared the performance of the Carba NP (CNP) test using the CLSI tube method with that using a modified paper strip method for the detection of carbapenemases in 390 Enterobacteriaceae isolates. The isolates were identified by Hong Kong's carbapenem-resistant Enterobacteriaceae surveillance program in 2016 and comprised 213 CPE and 177 carbapenemase-negative Enterobacteriaceae isolates. Molecular genotype was used as the reference. The test results were read at different time points for the CLSI method (1 min, 5 min, 1 h, and 2 h) and strip method (1 min and 5 min). The strip CNP and CLSI CNP tests correctly detect carbapenemase production in 93% and 93% of KPC producers, 100% and 38% of IMI producers, 94% and 85% of IMP producers, 98% and 90% of NDM producers, and 29% and 12% of OXA producers, respectively. Overall, the strip method has superior sensitivity to the CLSI method (86% versus 75%, respectively; P < 0.001, McNemar test). The specificity of both methods was 100%. By the CLSI method, 27%, 14%, 29%, and 6% of the CPE isolates were positive at 1 min, 5 min, 1 h, and 2 h, respectively. In contrast, by the strip method, 76% of the CPE isolates were positive at 1 min, and an additional 10% were positive at 5 min. In conclusion, the Carba NP test by use of the modified strip method has a higher sensitivity and a shorter assay time than that those by use of the CLSI tube method.
Potential To Streamline Heterologous DNA Prime and NYVAC/Protein Boost HIV Vaccine Regimens in Rhesus Macaques by Employing Improved Antigens

ABSTRACT In a follow-up to the modest efficacy observed in the RV144 trial, researchers in the HIV vaccine field seek to substantiate and extend the results by evaluating other poxvirus vectors and combinations with DNA and protein vaccines. Earlier clinical trials (EuroVacc trials 01 to 03) evaluated the immunogenicity of HIV-1 clade C GagPolNef and gp120 antigens delivered via the poxviral vector NYVAC. These showed that a vaccination regimen including DNA-C priming prior to a NYVAC-C boost considerably enhanced vaccine-elicited immune responses compared to those with NYVAC-C alone. Moreover, responses were improved by using three as opposed to two DNA-C primes. In the present study, we assessed in nonhuman primates whether such vaccination regimens can be streamlined further by using fewer and accelerated immunizations and employing a novel generation of improved DNA-C and NYVAC-C vaccine candidates designed for higher expression levels and more balanced immune responses. Three different DNA-C prime/NYVAC-C+ protein boost vaccination regimens were tested in rhesus macaques. All regimens elicited vigorous and well-balanced CD8+ and CD4+ T cell responses that were broad and polyfunctional. Very high IgG binding titers, substantial antibody-dependent cellular cytotoxicity (ADCC), and modest antibody-dependent cell-mediated virus inhibition (ADCVI), but very low neutralization activity, were measured after the final immunizations. Overall, immune responses elicited in all three groups were very similar and of greater magnitude, breadth, and quality than those of earlier EuroVacc vaccines. In conclusion, these findings indicate that vaccination schemes can be simplified by using improved antigens and regimens. This may offer a more practical and affordable means to elicit potentially protective immune responses upon vaccination, especially in resource-constrained settings. IMPORTANCE Within the EuroVacc clinical trials, we previously assessed the immunogenicity of HIV clade C antigens delivered in a DNA prime/NYVAC boost regimen. The trials showed that the DNA prime crucially improved the responses, and three DNA primes with a NYVAC boost appeared to be optimal. Nevertheless, T cell responses were primarily directed toward Env, and humoral responses were modest. The aim of this study was to assess improved antigens for the capacity to elicit more potent and balanced responses in rhesus macaques, even with various simpler immunization regimens. Our results showed that the novel antigens in fact elicited larger numbers of T cells with a polyfunctional profile and a good Env-GagPolNef balance, as well as high-titer and Fc-functional antibody responses. Finally, comparison of the different schedules indicates that a simpler regimen of only two DNA primes and one NYVAC boost in combination with protein may be very efficient, thus showing that the novel antigens allow for easier immunization protocols.
QoE assessment of joint haptic drum performance: Effect of local lag control

This paper investigates the effect of local lag control on the synchronization quality of sound, interactivity, and comprehensive quality as QoE (Quality of Experience) in a networked haptic drum system. We handle joint performance in the system, where two users play a drum set in a 3D virtual space with the same rhythm at the same tempo. As a result, we illustrate that QoE depends on the network delay, and there exists the optimum value of local lag according to the network delay.
Anaplasma phagocytophilum surface protein AipA mediates invasion of mammalian host cells

Anaplasma phagocytophilum, which causes granulocytic anaplasmosis in humans and animals, is a tick‐transmitted obligate intracellular bacterium that mediates its own uptake into neutrophils and non‐phagocytic cells. Invasins of obligate intracellular pathogens are attractive targets for protecting against or curing infection because blocking the internalization step prevents survival of these organisms. The complement of A. phagocytophilum invasins is incompletely defined. Here, we report the significance of a novel A. phagocytophilum invasion protein, AipA. A. phagocytophilum induced aipA expression during transmission feeding of infected ticks on mice. The bacterium upregulated aipA transcription when it transitioned from its non‐infectious reticulate cell morphotype to its infectious dense‐cored morphotype during infection of HL‐60 cells. AipA localized to the bacterial surface and was expressed during in vivo infection. Of the AipA regions predicted to be surface‐exposed, only residues 1 to 87 (AipA1–87) were found to be essential for host cell invasion. Recombinant AipA1–87 protein bound to and competitively inhibited A. phagocytophilum infection of mammalian cells. Antiserum specific for AipA1–87, but not other AipA regions, antagonized infection. Additional blocking experiments using peptide‐specific antisera narrowed down the AipA invasion domain to residues 9 to 21. An antisera combination targeting AipA1–87 together with two other A. phagocytophilum invasins, OmpA and Asp14, nearly abolished infection of host cells. This study identifies AipA as an A. phagocytophilum surface protein that is critical for infection, demarcates its invasion domain, and establishes a rationale for targeting multiple invasins to protect against granulocytic anaplasmosis.
The Chitty effect: a consequence of dynamic energy allocation in a fluctuating environment.

An important biological feature of cyclic populations of voles and lemmings is phase-related changes in average body mass, with adults in high-density phases being 20-30% heavier than those in low-density phases of a cycle. This observation, called the "Chitty effect," is considered to be a ubiquitous feature of cyclic populations. It has been argued that understanding the Chitty effect is fundamental to unraveling the enigma of population cycles. However, there exists no agreement among biologists regarding the causes of the Chitty effect. Here, I propose a simple hypothesis to explain the Chitty effect, based on phase-related, dynamic allocation of energy between reproductive and somatic effort. The essence of the hypothesis is that: (1) reproduction is suppressed in animals born or raised in the later part of the increase phase by environmental factors, including social influences; (2) suppression of reproduction limits the amount of energy that is diverted for reproductive effort, and forces a disproportionately greater amount of surplus power (the energy left after the energetic costs of standard and active metabolism are met) to be allocated for somatic effort; (3) the surplus energy, above and beyond what is required for routine biological activities, will allow continuous growth and deposition of additional body mass, which causes an increase in body mass; and (4) animals grow to a larger size as a population enters the peak density phase, causing an increase in the average body mass. The Chitty effect is predicted to be most pronounced at the late increase or peak phase of a population cycle. Possible causes of reproductive suppression include direct or indirect influences of the environmental factors. The Chitty effect may be a consequence, not a cause, of population cycles in small mammals.
Prevalence of latent tuberculosis and treatment adherence among patients with chronic kidney disease in Campo Grande, State of Mato Grosso do Sul.

INTRODUCTION The primary strategy for tuberculosis control involves identifying individuals with latent tuberculosis. This study aimed to estimate the prevalence of latent tuberculosis in chronic kidney disease (CKD) patients who were undergoing hemodialysis in Campo Grande, State of Mato Grosso do Sul, Brazil, to characterize the sociodemographic and clinical profiles of patients with latent tuberculosis, to verify the association between sociodemographic and clinical characteristics and the occurrence of latent tuberculosis, and to monitor patient adherence to latent tuberculosis treatment. METHODS This epidemiological study involved 418 CKD patients who were undergoing hemodialysis and who underwent a tuberculin skin test. RESULTS The prevalence of latent tuberculosis was 10.3%. The mean patient age was 53.43±14.97 years, and the patients were predominantly men (63.9%). The population was primarily Caucasian (58.6%); half (50%) were married, and 49.8% had incomplete primary educations. Previous contact with tuberculosis patients was reported by 80% of the participants. Treatment adherence was 97.7%. CONCLUSIONS We conclude that the prevalence of latent tuberculosis in our study population was low. Previous contact with patients with active tuberculosis increased the occurrence of latent infection. Although treatment adherence was high in this study, it is crucial to monitor tuberculosis treatment administered to patients in health services to maintain this high rate.