Miracle-dz/UniFAR-FTUs huggingface dataset:
Functional analysis of lncRNAs based on competitive endogenous RNA in tongue squamous cell carcinoma

Backround Tongue squamous cell carcinoma (TSCC) is the most common malignant tumor in the oral cavity. An increasing number of studies have suggested that long noncoding RNA (lncRNA) plays an important role in the biological process of disease and is closely related to the occurrence and development of disease, including TSCC. Although many lncRNAs have been discovered, there remains a lack of research on the function and mechanism of lncRNAs. To better understand the clinical role and biological function of lncRNAs in TSCC, we conducted this study. Methods In this study, 162 tongue samples, including 147 TSCC samples and 15 normal control samples, were investigated and downloaded from The Cancer Genome Atlas (TCGA). We constructed a competitive endogenous RNA (ceRNA) regulatory network. Then, we investigated two lncRNAs as key lncRNAs using Kaplan–Meier curve analysis and constructed a key lncRNA-miRNA-mRNA subnetwork. Furthermore, gene set enrichment analysis (GSEA) was carried out on mRNAs in the subnetwork after multivariate survival analysis of the Cox proportional hazards regression model. Results The ceRNA regulatory network consists of six differentially expressed miRNAs (DEmiRNAs), 29 differentially expressed lncRNAs (DElncRNAs) and six differentially expressed mRNAs (DEmRNAs). Kaplan-Meier curve analysis of lncRNAs in the TSCC ceRNA regulatory network showed that only two lncRNAs, including LINC00261 and PART1, are correlated with the total survival time of TSCC patients. After we constructed the key lncRNA-miRNA -RNA sub network, the GSEA results showed that key lncRNA are mainly related to cytokines and the immune system. High expression levels of LINC00261 indicate a poor prognosis, while a high expression level of PART1 indicates a better prognosis.
Quality Of Life of Patients with Type 2 Diabetes

Introduction: Quality of life is important for people with diabetes and their healthcare providers for several reasons. This is because many people who suffer from diabetes and who have poor quality of life, often have less attention to their self-care and disease management. When self-care is diminished in diabetes, it in turn leads to poor glycemic control and increased risk of complications. Thus, quality of life issues are crucially important because they may powerfully predict an individual’s capacity to manage his/her disease and maintain long term health and wellbeing.Aim:To assess the HRQOL among Type 2 Diabetic subjects in Visakhapatnam district of Andhra Pradeshstate so as to study the correlation between demographic characters of T2DM subjects with various domains of HRQOL and to contribute to the existing epidemiological data of the country. Methods: After obtaining approval from the IEC and valid informed consent, the patients were recruited into the study. A cross-sectional descriptive questionnaire-based study was conducted amongstT2DM subjects. The study was carried out in 454 subjects who were chosen from outpatient / in patient departments in hospitals/clinics from Visakhapatnam of Andhra Pradesh state. Results: Our results suggest that complications had a negative impact on the following fields of QOL: role limitation due to physical health, physical endurance, general health, symptom botherness, treatment satisfaction, financial worries, emotional / mental health and diet satisfaction.Conclusion:Diabetes does impair the QoL of patients. There is a need to specifically target and improve the QoL of diabetics who are at risk of a poor QoL. QoL assessment should be routinely practiced in diabetic clinics.
Role of RPE Cells in Pathogenesis of Proliferative Vitreoretinopathy and Age-Related Macular Degeneration : Cell Culture Study of Surgical Excised Pre-and SubRetinal Membranes

Objectives: There were few studies on the culture of cells from surgical excised preor sub-retinal membranes from Proliferative Vitreoretinopathy (PVR) and Age-Related Macular Degeneration (AMD) patients and all of these studies were restricted to primary cultures only. The purpose of this study was to culture and identify various cellular components of surgically excised membranes from these patients and to explore the role of these cells in the pathogenesis of PVR and AMD by the investigation of the in vitro behavior of these cells in and beyond the primary culture. Methods: Surgically excised membranes were plated in culture dishes by an explants method and cultured with F12 medium containing fetal bovine serum. Immunocytochemical staining was performed to identify cell types. After the confluence of primary culture, cells were subcultured until senescence. Results: Of the membranes from 41 PVR eyes, 29 cases exhibited cell outgrowth (71%), and 13 cases (32%) grew to confluence. RPE cells, glial cells, fibroblasts and macrophages were the main cell types identified in the outgrowth of these membranes. RPE cells were the predominant and most actively growing cell type and the sole cell type persisted after second subcultures. RPE cells could be cultured up to 12 generations with 30 divisions in vitro. Of the membranes from 16 AMD eyes, 5 (31%) demonstrated cell outgrowth, but none of these cultures became confluent. Conclusions: Cells from PVR membranes exhibited active proliferation and were predominantly RPE cells. Cells from sub-retinal membranes of AMD eyes showed poor viability and growth capacity. These results were consistent with the pathologic and cell biologic changes of RPE cells in the AMD and PVR.
Mast-cell degranulation induced by physical stimuli involves the activation of Transient-Receptor-Potential Channel TRPV 2

Shanghai Research Center for Acupuncture and Meridians, Department of Mechanics and Engineering Science, Fudan University, Shanghai 200433, China 2 Max-Planck-Institute for Biophysics, Frankfurt am Main 60438, Germany 3 State Key Laboratory of Medical Neurobiology, Shanghai Medical College, Fudan University, Shanghai, 200032, China 4 Institute for Biophysics, Goethe University Frankfurt, Frankfurt am Main 60438, Germany
Room temperature ferromagnetism and its correlation to ferroelectricity of manganese embedded in lead zirco-titanate Ioana

Manganese is deposited at high temperature on (001) oriented ferroelectric lead zirco-titanate prepared in two different ways: sputter-annealed or just simply annealed in ultrahigh vacuum. Room temperature ferromagnetism (FM) is obtained for Mn deposited on sputter-annealed substrates, while for the other sample preparation a paramagnetic behaviour is obtained. Also, for the first case a clear inwards component of the polarization P is observed by X-ray photoelectron spectroscopy and piezoresponse force microscopy. Composition analysis evidenced formation of Pb vacancies in the case of FM – P sample, consistent with hole formation near the surface, needed both to stabilize the inwards polarization state and to intermediate ferromagnetism between Mn ions. The indirect exchange ferromagnetism mediated by holes is stronger, most probably because the interaction energy is proportional with the carrier effective mass. Also, whereas in the case of unsputtered substrate a stable surface Mn oxide is formed, defect formation by sputtering seems to favor Mn migration inside the sample. This also induces the formation of a thin film where ferromagnetism and the orientation of ferroelectric polarization might have the same origin, i. e. holes accumulated near the outer
The Processing Speed of Visual and Verbal Movement Information by Adults with and Without Down Syndrome

Previous research has indicated that individuals with Down syndrome (DS) have difficulties processing auditory movement information relative to their peers with undifferentiated developmental disabilities. The present study was conducted to assess whether a model of atypical cerebral specialization could explain these findings. Thirteen adults with Down syndrome (8 men, 5 women), 14 adults with undifferentiated developmental disabilities (7 men, 7 women), and 14 adults without disabilities (8 men, 6 women) performed rapid aiming movements to targets under three conditions: a visual cue at the target location, a visual cue remote from the target location, or a verbal cue. Results revealed that, while the reaction times did not differ between the two groups with disabilities across conditions, the participants with DS, unlike their peers, had significantly longer movement times in the verbal than in two visual conditions. These results are consistent with the model of biological dissociation.
Involvement of endothelial nitric oxide synthase gene variants in the aggressiveness of uterine cervical cancer

To date, few studies explore the involvement of endothelial nitric oxide synthase (eNOS) gene variants in uterine cervical cancer. Therefore, we conducted this study to assess the clinical implication of eNOS in cervical carcinogenesis, clinicopathological characteristics and patient survival. One hundred and seventeen patients with cervical invasive cancer and 95 with preinvasive lesions and 330 control women were consecutively enrolled. Real time polymerase chain reaction was used to examine the genotypic distributions of eNOS single nucleotide polymorphisms (SNPs) rs1799983 (894G>T) at the exon 7 region and rs2070744 (-786T>C) at the promoter region. Our results indicated no significant associations among genotypic distributions of eNOS SNPs and patients with cervical invasive cancer and those with preinvasive lesions as well as normal controls. However, cervical cancer patients with genotypes TC/CC in eNOS SNP rs2070744 carried less risk of advanced stage [odds ratios (OR) = 0.30, 95% confidence interval (CI)=0.09-0.97, p=0.036], parametrium invasion (OR=0.16, 95% CI=0.02-0.75, p=0.009) and pelvic lymph node metastasis (OR=0.12, 95% CI=0.01-0.89, p=0.016). In conclusion, although eNOS SNPs rs2070744 and rs1799983 do not display significant associations with cervical carcinogenesis and patient survival, cervical cancer patients with genotypes TC/CC in rs2070744 carry less risk of advanced stage, parametrium invasion and pelvic lymph node metastasis in Taiwan.
Transport of multiple tracers in variably saturated humid regionstructured soils and semi-arid region laminated sediments

The processes governing physical nonequilibrium (PNE)—coupled preferential flow and matrix diffusion—are diverse between humid and semi-arid regions, and are directly related to climate and rock/sediment type, and indirectly related to subsequent soil profile development. The fate and transport of contaminants in these variably saturated undisturbed media is largely a function of the influence of PNE processes. Large cores of laminated silts and sands were collected from the US Department of Energy Pacific Northwest National Laboratory (PNNL) in semi-arid south central Washington. Additional cores of weathered, fractured interbedded limestone and shale saprolite were collected from the Oak Ridge National Laboratory (ORNL) in humid eastern Tennessee. PNNL cores were collected parallel (FBP) and perpendicular (FXB) to bedding, and the ORNL core was 308 to bedding. Saturated and unsaturated transport experiments were performed using multiple nonreactive tracers that had different diffusion coefficients (Br, PFBA, and PIPES), in order to identify the influence of PNE on the fate and transport of solutes. In the ORNL structured saprolite, solute transport was governed by coupled preferential flow and matrix diffusion, as evidenced by tracer separation and highly asymmetric breakthrough curves (BTC). BTCs became more symmetric as preferential flowpaths became inactive during drainage. Tracer separation persisted during unsaturated flow suggesting the continued importance of nonequilibrium mass transfer between flowpaths and the immobile water that was held in the soil matrix. No evidence of PNE was observed under near-saturated conditions in the semi-arid region (PNNL) laminated silts and sands. Unsaturated flow in cores with discontinuous layering resulted in preferential flow and the development of perched, immobile water as evidenced by early breakthrough and separation of tracers. Conversely, transport parallel to laterally continuous beds did not result in preferential flow, the development of perched water, or tracer separation regardless of water content. These observations suggested that desaturation had two effects: (1) grain size variations between individual beds resulted in different antecedent water contents, and (2) the exchange of water and solutes between individual sedimentary beds was subsequently inhibited. Under unsaturated conditions, these effects may promote either stable lateral flow, or unstable vertical finger flow coupled with the development of perched, immobile water. q 2003 Elsevier Science B.V. All rights reserved.
Burden of Caregivers Care for Children with Thalassemia at Babylon Child and Maternity Teaching Hospital / Babylon Governorate / Iraq Dr .

Objectives : to assess the psychological burden of caregivers of thalassemia children, the social burden of caregivers of thalassemia children, and to find out the association between psychological and social variables with the demographic characters of caregivers like age , level of education, occupation , and residential area. Methodology : Descriptive design study ,purposive sample of (100) caregivers who attending the Babylon Pediatric and Maternity Teaching Hospital . Questionnaire was used to collect the data for the period from 26 th march to 27 th may 2013, data were analyzed by using descriptive statistical (percentage , frequency and mean score ) and inferential ( chi-square). Result: the study presents that(55%) of caregivers are mothers and (34%) are relatives, (82%) of caregivers are feeling fear of future ,while (66%) of them have no pleasure in life, Also the results show that (82%) are hoping to treat their children in private hospital . Conclusion :The majority of caregivers are hoping to treat their children in private hospitals and this makes them feel guilty toward their children . Recommendation : Further studies with larger sample size or multicentre studies with longer period of follow up.
The Theoretical and Empirical Basis for Graphic Organizer Instruction

For over three decades, researchers have examined the effectiveness of graphic organizers for aiding the comprehension of students in content classrooms. The purpose of this study is to evaluate the effects of the type and specificity of embedded graphic organizer prompts on the achievement of relational knowledge of typical students and students with learning disabilities and how these embedded graphic organizer prompts influence the memory processing strategies used by teachers during instruction.
FACTORS AFFECTING IS SUCCESS AND TECHNOLOGY ACCEPTANCE : A CASE STUDY

Today, Information technology is the concern of corporate executives, and a challenge in ensuring alignment between the functions of information systems and business. PT. XYZ is one of the insurance company in Indonesia that has implemented the core information system for operational, however, the fact is that the number of complaints against the system, and the reluctance to use the system continues to increase. This study will evaluate the core operational information system in PT. XYZ using IS success model Delone McLean and technology acceptance model in evaluating factors influencing IS success and technology acceptance and determining factors that still need to be improved in achieving IS success and technology acceptance to company information system that has been implemented. The number of samples is 194 respondents, and all of them are employees of PT. XYZ that uses the core information system. Data obtained from questionnaires distributed to respondents and measurement of validity, reliability and regression analysis using SPSS 20. Found that the most important factor of IS success and technology acceptance is information quality.
Studies on the morphology of the olfactory organ in the freshwater teleost, Labeo bata (Hamilton

The structural components of the olfactory apparatus of Labeo bata (Hamilton, 1822) were studied morphologically as well as histologically. The oval shaped olfactory rosette was comprised of 24-26 lamellae of different sizes on each side of the median raphe. Histologically each lamella was composed of two layers of olfactory epithelium separated by narrow central core which made up of loose connective tissues, nerve fibres and blood vessels. The sensory olfactory epithelium contained principally three types of receptor cells: primary, secondary and microvillous cells. The non-sensory epithelium was typified with a series of mucous cells, stratified epithelial cells and mast cells. Basal cells were situated at the base of the epithelium, adjacent to the central core. Various cells on the olfactory epithelium were correlated with their functional consequence of fish concerned.
Incidence of E. coli and Salmonellae in ready to eat fast foods

A total of 100 random samples of readyto – eat sandwiches of beef products represented by kofta, liver, shawerma and sausage products (25 samples of each) were collected from different fast food services in different districts at kaliobia Governorate to be examined bacteriologically for detection of Salmonellae and Escherichia coli. The perecentages of Salmonellae in the examined samples of kofta, liver, shawerma and sausage products were 32%, 60%, 8% and 40%, respectively. The obtained results indicated that the incidence of E. coli was 20%, 8% and 32% and 40% in the examined kofta, shawerma, sausage and liver samples, respectively.
Contextual Priming for Action Recognition in Realistic Videos Selection of database and feature descriptors

As the first step into the project of Contextual Priming for Action Recognition in Realistic Videos, in this report we will investigate different human action databases and find the one that best matches requirements of the project. Furthermore, we will more or less decide what type(s) of feature descriptors to work with. This decision is made based on an early anticipations of the experiments that we will need later in order to dissect influence of scene context in action recognition. We would like to investigate the effect of motion/shape/color properties on the joint distribution of action and context.
Determinants of Consumer Switching Behavior in Mobile Telephony Industry in Kenya

Mobile number portability allows mobile phone subscribers to switch operators without changing their telephone numbers. Subscribers are allowed to choose their preferred network based on such aspects as customer care, quality of service, value added services and the cost of communicating on the network while retaining their telephone number. Kenya implemented this service in April 2011 with the first month of implementation recording the highest number of ports. This paper seeks to establish the factors that influence consumer switching behavior; that compel subscribers to port their cell phone numbers as they migrate to new service providers. Regression results show a strong relationship between the consumer intention to switch and the “Push Determinants” i.e. the duration and the cost of porting. Other determinants identified are the “Swayer Determinants” which include the period of usage, age, and the average amount spent on airtime. These were found to have a minimal influence on the intention to switch. Furthermore, results indicate that 68% of the respondents had intention of switching but the existing legal framework was found to be ineffective in facilitating an increase in the porting rate. We recommend further regulatory measures to address the dominance or non cooperation of the main players who frustrate the porting process leading to lengthy and cumbersome switching procedures that make it difficult for desiring subscribers to switch. Finally, Mobile Number Portability awareness should be transparent and non manipulative.
Physiological Characteristics of Dalbergia melanoxylon and Dalbergia sissoo seeds

The objectives of this work were to study physiological characteristics of Dalbergia melanoxylon (Abanous, Babanous) and Dalbergia sissoo seeds, and to explore a seed breaking dormancy methods. The study also aimed to compare between the indigenous species D.melanoxylon and exotic one D.sissoo in seed morphology. Seed physical and physiological characteristics were explored through the determination of seed soundness, damaged and abortive seeds, purity percentage, number of seeds per kilogram, seed moisture content percentage, viability percentage, germination rate, percentage and the phenomenon of seed dormancy. The study revealed that more than 70% of D.melanoxylon seeds were abortive or damaged by insects when collected. Seed characteristics of the both D.melanoxylon and D.sissoo were found to be more or less similar. Extraction of seeds from the pods, sulphuric acid for one minute and dewinging were found to be the best treatments for dormancy breaking. Seeds were found to have a combined external dormancy of chemical and physical type. The study revealed that seeds kept in the normal store and the cool store for 18 months had more or less the same germination behavior. Seed viability was kept high in both stores throughout storage period.
WINTER DISTRIBUTION OF WESTERN SNOWY PLOVERS (CHARADRIUS ALEXANDRINUS NIVOSUS) IN HUMBOLDT COUNTY – 2007/08, 2008/09

Conservation of threatened and endangered species requires managing habitat for both breeding and nonbreeding seasons. The factors that influence habitat selection by the threatened Western Snowy Plover (Charadrius alexandrinus nivosus) during the nonbreeding season are poorly understood. We examined the distribution of Western Snowy Plovers in coastal northern California during the nonbreeding season over two consecutive years. The plovers that wintered in northern California included residents and migrants from other areas. Individual plovers demonstrated high site faithfulness within the nonbreeding season, occupying small home ranges (1331 ± 1382.9 m). Occupied sites had more brown algae and associated invertebrates, were wider, and had less debris in the foredune than unoccupied sites. These findings suggest that during the nonbreeding season Snowy Plovers select habitats that have more food and where birds could more easily detect predators. The results from this study provide information that can be used to identify habitat for nonbreeding Snowy Plovers and to incorporate nonbreeding habitat into restoration efforts. Maintaining nonbreeding habitat in northern California is important not only to the local population, but other populations as well.