Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparison of energy-efficiency in bits per joule on different downlink CoMP techniques

Coordinated MultiPoint (CoMP) transmission / reception techniques have been adopted by the 3GPP community for LTE-Advanced (Long Term Evolution-Advanced) to increase spectral efficiency and cell-edge throughput. Energy efficiency (EE) was previously ignored by most research efforts and was not considered by 3GPP as an important performance indicator until very recently. EE concerns have spurred considerable research in recent years as they enable both energy consumption and CO2 reduction over conventional cellular systems. As the “green evolution” becomes a major trend, energy-efficient transmission becomes more and more important. In this paper we investigate energy efficiency i.e., the number of corrected bits that can be transmitted throughout the channel per joule of energy consumed of different downlink CoMP techniques in LTE-Advanced. In addition, we use system level simulation to evaluate the performance.
Risk Factors of Alzheimer ’ s Disease : Depression in the Cross Fire

Alzheimer’s disease (AD) is the most frequent cause of cognitive decline by the elderly, leading to immense medical and economic burden on our aging society. The 2015 World Alzheimer Report estimated 48.8 million people worldwide living with dementia. Likely, their numbers will double every 20 years [1]. In the last decades, fascinating studies revealed many molecular pathways in the background of AD. However, most of the clinical trials aiming to treat the disease have failed. Recently, growing body of evidence suggests that we have to pay more attention to primer prevention and to active aging. Ongoing studies emphasize that creative leisure activities, physical activity and appropriately selected diet could prevent the development of dementia or slow the progression of the disease [2]. The mechanism is not entirely clarified; it seems to be related to the improved lipid metabolism, to optimal level of antioxidant and anti-inflammatory factors and to activated brain plasticity and vascularization.
Occupational health today and tomorrow: a view from two shipyards. The Milroy lecture 1988.

end to the epidemic of asbestos-induced mesothelial tumours is in sight, and the framework of health and safety legislation is both sensible and wisely administered. But beneath the surface there is in the UK cause for concern. This paper indicates some of the problems and attempts possible solutions. It is set in the context of a research study into the respiratory health of shipyard workers where many of the problems were experienced at
Transitioning to Independence: Challenges for Young People with Disabilities and their Caregivers

For all teens, the process of moving from childhood to adulthood is challenging. For young people with disabilities, transitioning to independence presents even more challenges. Barriers to successful transition for young people with disabilities include low expectations by parents and other significant people in the community, lack of knowledge of existing career and vocational education services, and lack of self-advocacy skills. This article provides an overview of issues related to transitioning to adult independence and offers suggestions for assessment, planning, and intervention that can help nurses be effective partners with families and other caregivers in transition efforts. Nurses caring for children with disabilities can help families see strengths in their children and develop realistic, developmentally-appropriate expectations for skill development, attitudes, and behaviors that will promote self-sufficiency in adulthood. Nurses can help families think about possibilities for independence and refer families to community resources that can help young people with disabilities pursue postsecondary education, obtain and maintain jobs, and live independently. The national CHOICES Project (Children's Healthcare Options Improved through Collaborative Efforts and Services) promotes collaboration among Shriners Hospitals, state Children with Special Health Care Needs (Title V), Early Intervention, and Vocational Rehabilitation programs with the goal of creating a seamless system of tertiary medical care and community health and social services for young people with disabilities. People in Shriners Hospitals and state agencies across the country have contributed ideas to this manuscript, and the authors sincerely thank them. Funding for the CHOICES Project comes from Shriners Hospitals for Children and the Maternal and Child Health Bureau.
Sequence analysis of an HIV‐1 isolate which displays unusually high‐level AZT resistance in vitro

Multiple mutations in the reverse transcriptase (RT) gene were observed in a drug‐resistant isolate of human immunodeficiency virus type 1 (HIVI) from an individual having prolonged (<2 years) zidovudine (AZT) therapy. The virus replicated in PBMC′s in the presence of very high concentrations of AZT (1 25 μM). Drug‐sensitive strains were curtailed by 0.01 μM AZT.
Haematological, lipid profile and other biochemical parameters in normal and hypertensive subjects among the population of the eastern province of Saudi Arabia.

OBJECTIVE To determine the lipid profile complete blood count and other biochemical parameters in normotensive and hypertensive individuals. DESIGN Cross-sectional population-based epidemiological household survey. SETTING Population sample of the Eastern Province of Saudi Arabia. RESULTS Hypertensive individuals had significantly higher mean levels of glucose, Tc, LDL-c, HDL-c, triglycerides and HBAIc, compared to normotensive individuals while there were no significant difference in the mean levels of Apo AI and Apo B. Within the same group there were variations in the levels of certain parameters between male and female. While the mean levels of haemoglobin, WBC and platelets were significantly higher in the hypertensive group compared to normotensive, there were no significant differences between these two groups in the levels of RBC, MCV, HCT, MCH and MCHC. However, the mean levels haemoglobin, RBC count and HCT were significantly higher in male compared to female within the same group with no significant difference in levels of WBC, MCV, MCH and MCHC. Furthermore, the mean concentration of platelets was significantly higher in females compared to male within the same group. Hypertensive individuals had significantly higher serum sodium, chloride and calcium levels but a significantly lower potassium level when compared to normotensive with no siginificant differences between male and female within the same group. CONCLUSION The lipid and electrolyte profile of hypertensive individuals differ from that of normotensive individuals in this population. This study has contributed towards establishing the normal values for a number of parameters involved in the aetiology of cardiovascular diseases in the population of Eastern province.
Mild traumatic brain injury: longitudinal regional brain volume changes.

PURPOSE To investigate longitudinal changes in global and regional brain volume in patients 1 year after mild traumatic brain injury (MTBI) and to correlate such changes with clinical and neurocognitive metrics. MATERIALS AND METHODS This institutional review board-approved study was HIPAA compliant. Twenty-eight patients with MTBI (with 19 followed up at 1 year) with posttraumatic symptoms after injury and 22 matched control subjects (with 12 followed up at 1 year) were enrolled. Automated segmentation of brain regions to compute regional gray matter (GM) and white matter (WM) volumes was performed by using three-dimensional T1-weighted 3.0-T magnetic resonance imaging, and results were correlated with clinical metrics. Pearson and Spearman rank correlation coefficients were computed between longitudinal brain volume and neurocognitive scores, as well as clinical metrics, over the course of the follow-up period. RESULTS One year after MTBI, there was measurable global brain atrophy, larger than that in control subjects. The anterior cingulate WM bilaterally and the left cingulate gyrus isthmus WM, as well as the right precuneal GM, showed significant decreases in regional volume in patients with MTBI over the 1st year after injury (corrected P < .05); this was confirmed by means of cross-sectional comparison with data in control subjects (corrected P < .05). Left and right rostral anterior cingulum WM volume loss correlated with changes in neurocognitive measures of memory (r = 0.65, P = .005) and attention (r = 0.60, P = .01). At 1-year follow-up, WM volume in the left cingulate gyrus isthmus correlated with clinical scores of anxiety (Spearman rank correlation r = -0.68, P = .007) and postconcussive symptoms (Spearman rank correlation r = -0.65, P = .01). CONCLUSION These observations demonstrate structural changes to the brain 1 year after injury after a single concussive episode. Regional brain atrophy is not exclusive to moderate and severe traumatic brain injury but may be seen after mild injury. In particular, the anterior part of the cingulum and the cingulate gyrus isthmus, as well as the precuneal GM, may be distinctively vulnerable 1 year after MTBI.
Contribution of Street Foods to Nutrient Intakes by Nigerian Adolescents

The food and nutrient intake and the proportion of these supplied by street foods was studied in a group of 142 adolescent Nigerians, using structured questionnaire, 24-hour recall and weighed intake protocols. The results show that all the major groups of foods are represented in the menu and street food providing, overall, the major sources of dairy, meat, fish and egg. Mean intake of energy was 10.85 MJ for the cohort with street foods contributing almost 25%. For male subjects, 21% of the energy came from street foods while for females, the proportion was 29%. Also out of the mean intake of 62g total protein, street foods supplied over 50% for both male and female. The proportion was even higher for calcium (64%) and vitamin A (almost 60%). For all the other minerals and vitamins examined, street foods supplied over 50% of the intake.
Gene profile of replicative senescence is different from progeria or elderly donor.

In vitro cellular senescence of human diploid fibroblast has been a good model for aging research, which shows similar phenotypes to in vivo aging. Gene expression profiling would provide an insight to understand the mechanism of senescence. Using cDNA microarray containing 384 known genes, we compared the expression profiles of three different types of aging models: replicative senescence, fibroblasts from progeria or from elderly donor. Although all of them showed senescence phenotypes, distinct sets of genes were altered in each group. Pairwise plots or cluster analysis of activation fold of gene expression revealed closer relationships between fibroblasts from progeria or from old individual, but not between replicative senescence fibroblasts and either models. Differential expression pattern of several genes were confirmed by RT-PCR. We suggest that the replicative senescence model might behave differently to other types of aging models due to the distinct gene expression.
A Case of Exfoliation of Oral Mucosal Epithelium in a Patient with Anti-Desmoglein 1 Antibody-Positive and Anti-Desmoglein 3 Equivocal Antibody

Pemphigus is an autoimmune bullous disease observed with lesions in the skin and mucosa. Pemphigus is classified by antibodies against desmogleins, which is cadherin type intercellular adhesion factors involved in adhesion between epidermal cells. In this case, because erosion of the oral mucosa was the primary symptom, a relationship with membrane-dominant pemphigus vulgaris was strongly suspected. And in terms of histopathology, findings not conflicted with pemphigus vulgaris were observed, but given all these different findings, the results did not correspond with bullous pemphigoid in clinical findings, and with pemphigus foliaceus and pemphigus vulgaris in various testing results, leading us to believe this represented a very rare case. We started oral health care, and when application of steroid ointment to the entire surface of the mucosa was continued, symptoms disappeared within approximately 2 months. In this case, relapse has not yet occurred and periodic follow-up was continued.
Countertransference hate in the treatment of suicidal patients.

The countertransference hatred (feelings of malice and aversion) that suicidal patients arouse in the psychotherapist is a major obstacle in treatment; its management through full awareness and self-restraint is essential for successful results. The therapist's repression, turning against himself, reaction formation, projection, distortion, and denial of countertransference hatred increase the danger of suicide. Such antitherapeutic stances, their recognition, and the related potential for constructive or destructive action are the subject of this paper.
Histo‐anatomy of the proximal femur in rats: Impact of ovariectomy on bone mass, structure, and stiffness

Hip fractures are the most devastating consequence of osteoporosis in humans. Since the ovariectomized (ovx) rat is a useful model of estrogen‐deficient osteoporosis, the purposes of this study were to describe the histo‐anatomical features of the rat hip and to determine changes in the proximal femur induced by ovariectomy to evaluate the use of this skeletal site for future bone studies.
Proteomic profile of a therapy related acute myeloid leukemia following brain tumor

University Research Institute for the Study and Treatment of Childhood Genetic and Malignant Diseases, University of Athens, ‘Aghia Sophia’ Children’s Hospital, Athens, Greece, Division of Biotechnology, Center of Basic Research, Foundation for Biomedical Research for the Academy of Athens, Athens, Greece, Hematology/Oncology Unit, First Department of Pediatrics, University of Athens, ‘Aghia Sophia’ Children’s Hospital, Athens, Greece, and Department of Neurosurgery, ‘Aghia Sophia’ Children’s Hospital, Athens, Greece
Non-small cell lung cancer : two decades of progress

This review traces advances in the screening, diagnosis and staging of non-small cell lung cancer (NSCLC) and undertakes a thorough review of treatment developments over the past 20 years. It considers changes in surgical practice from open thoracotomy to video-assisted thoracoscopic lobectomy, the potential of expanding radiotherapy as definitive treatment and the evolution of thinking around sequential versus concurrent chemotherapy and radiotherapy in the advanced setting. Progress in the number and effectiveness of chemotherapies for first-line, second-line and maintenance therapy is presented. A number of agents targeting identifiable mutations have already been approved, with additional agents being investigated to overcome resistance. Current and future efforts will continue the search for actionable mutations and agents to target them. Finally, the current knowledge of and future prospects for immunotherapy, including results with the first checkpoint inhibitor, are described.
Use of urea as a chemosensory cloaking molecule by a bony fish

SUMMARY Because urea is bioenergetically expensive to synthesize, few aquatic teleostean (bony) fish make or excrete much urea beyond early development and excrete the majority of nitrogenous waste as the readily diffusible ammonia. The gulf toadfish is one of a few adult teleostean fish that excretes predominately urea. Most studies of chemosensing by fish predators have focused on amino acids as odorants, but we tested the chemo-attractiveness of both urea and ammonia. We report that characteristic `prey-attack' behaviors by a key toadfish predator, gray snapper, were elicited by low ammonia concentrations (<100 nmol N l-1) and similar urea concentrations blunted the ammonia-induced component of attacks. Thus, urea functions as a cloaking molecule, explaining why toadfish co-excrete urea with ammonia. Furthermore, ammonia waste is an important chemical attractant for piscine predators.
Role of asialo-GM1-positive lymphoid cells in mediating the toxic effects of recombinant IL-2 in mice.

Studies were performed to characterize the toxic effects of human rIL-2 in mice and to examine the mechanism of toxicity. Intraperitoneal administration of rIL-2 at doses greater than or equal to 2 X 10(6) U/kg twice each day for greater than or equal to 4 days led to toxicity in several strains of mice. The toxic effects of rIL-2 included the vascular leak syndrome (manifested by pulmonary edema, pleural effusions, and ascites), elevated hepatic transaminases, hyperbilirubinemia, hypoalbuminemia, pre-renal azotemia, anemia, thrombocytopenia, mild eosinophilia, and death. Marked lymphoid cell infiltration of pulmonary and hepatic vasculature was present in mice suffering from rIL-2 toxicity, and the pleural and ascitic fluids also contained high numbers of mononuclear cells. Mononuclear cells isolated from the pleural fluids and livers of these mice were 74 to 98% Thy-1+, 55 to 83% asialo-GM1+, 29 to 45% Lyt-2+, and less than 10% L3T4+. These cells possessed potent lymphokine-activated killer (LAK)-like activity in that their ability to lyse cells of the NK-resistant P815 mastocytoma line was 10- to 100-fold higher on a per cell basis than splenocytes from the same animals. A correlation was found between the dose level, duration, and frequency of dosing with rIL-2 required to induce pleural effusions and hepatotoxicity and the dosage regimens required to produce the LAK-like cells in the pleural cavities and livers, respectively, of rIL-2-treated mice. Moreover, treatment of mice with anti-asialo-GM1 (anti-ASGM-1) antiserum in vivo at the same time they were receiving toxic doses of rIL-2 abolished or greatly reduced the severity of the vascular leak syndrome and hepatotoxicity and significantly prolonged the survival of the mice. Administration of anti-ASGM-1 to mice receiving toxic doses of rIL-2 resulted in a marked reduction in the LAK-like cytolytic activity of their pleural and liver lymphoid cells and a corresponding reduction in the percentage of ASGM-1+ cells in pulmonary and hepatic lymphoid infiltrates. Nevertheless, the overall extent of pulmonary and hepatic lymphoid infiltration, as well as other consequences of rIL-2 administration, including splenomegaly, hypoalbuminemia, eosinophilia, and thrombocytopenia, were not diminished as a result of anti-ASGM-1 treatment. (ABSTRACT TRUNCATED AT 400 WORDS)
Effect of clear-felling and harvest residue removal on nitrogen and phosphorus export from drained norway spruce mires in southern finland

1) Natural Resources Institute Finland, P.O. Box 18, FI-01301 Vantaa, Finland (*corresponding author’s e-mail: mika.nieminen@luke.fi) 2) Department of Forest Sciences, P.O. Box 27, FI-00014, University of Helsinki, Finland 3) Natural Resources Institute Finland, P.O. Box 68, FI-80101 Joensuu, Finland 4) Trinity College Dublin, School of Engineering, Trinity College Dublin, College Green, Dublin 2, Ireland 5) Aalto University School of Engineering, Department of Civil and Environmental Engineering, Water Resources Engineering, P.O. Box 15200, FI-00076 Aalto, Finland
Medication Adherence using Non-intrusive Wearable Sensors

Activity recognition approaches have been applied in home ambient systems to monitor the status and well-being of occupant especially for home care systems. With the advancement of embedded wireless sensing devices, various applications have been proposed to monitor userâ ĂŹ s activities and maintain a healthy lifestyle. In this paper, we propose and evaluate a Smart Medication Alert and Treatment Electronic Systems (SmartMATES) using a non-intrusive wearable activity recognition sensing system to monitor and alert an user for missing medication prescription. Two sensors are used to collect data from the accelerometer and radio transceiver. Based on the data collected, SmartMATES processes the data and generate a model for the various actions including taking medication. We have evaluated the SmartMATES on 9 participants. The results show that the SmartMATES can identify and prevent missing dosage in a less intrusive way than existing mobile application and traditional approaches.
The effects of Lyman-limit systems on the evolution and observability of the epoch of reionization

We present the first large-scale, full radiative transfer simulations of the reionization of the intergalactic medium in the presence of Lyman-limit systems (LLSs). To illustrate the impact of LLS opacity, possibly missed by previous simulations, we add either a uniform or spatially varying hydrogen bound–free opacity. This opacity, implemented as the mean free path (MFP) of the ionizing photons, extrapolates the observed, post-reionization redshift dependence into the epoch of reionization. In qualitative agreement with previous studies, we find that at late times the presence of LLSs slows down the ionization fronts, and alters the size distribution of H II regions. We quantitatively characterize the size distribution and morphological evolution of H II regions and examine the effects of the LLSs on the redshifted 21-cm signal from the patchy reionization. The presence of LLSs extends the ionization history by Δz ∼ 0.8. The LLS absorbers significantly impede the late-time growth of the H II regions. The position-dependent LLS distribution slows reionization further and additionally limits the late growth of the ionized regions. However, there is no ‘freeze out’ of the H II regions and the largest regions grow to the size of the simulation volume. The 21-cm power spectra show that at large scales the power drops by a factor of 2 for 50 per cent and 75 per cent ionization stages (at k = 0.1 h Mpc−1) reflecting the limiting effect of the LLSs on the growth of ionized patches. The statistical observables such as the rms of the brightness temperature fluctuations and the peak amplitudes of the 21-cm power spectra at large scales (k = 0.05–0.1 h Mpc−1) are diminished by the presence of LLS.
Cervical cancer in HIV seropositive patients.

Cervical cancer is the second most common malignancy in women worldwide, second only to breast cancer and it remains a leading cause of cancerrelated death for women in developing countries. The incidence of invasive cervical cancer has declined steadily in developed countries over the past few decades; however, it continues to rise in many developing countries. Apart from the well known association of cervical cancer with Human papilloma virus (HPV), cervical cancer has been associated with Human Immunodeficiency virus (HIV), and it is classified as Acquired immunodeficiency syndrome (AIDS) defining disease since 1993 (CDC). Two thirds of the World Health Organization (WHO) estimated 40 million people in the world with Human Immunodeficiency Virus (HIV) live in Africa. One is yet to see if the HIV pandemic will have any effect on the epidemiological trend, natural history of cervical cancer, response to standard treatment and overall survival. Described below is recent experience with 3 cervical cancer patients with HIV infection.