Miracle-dz/UniFAR-FTUs huggingface dataset:
Fat-free mass index is superior to body mass index as a novel risk factor for prolonged air leak complicating video-assisted thoracoscopic surgery lobectomy for non-small-cell lung cancer.

Background To evaluate whether fat-free mass index (FFMI) could be predictive of prolonged air leak (PAL) complicating video-assisted thoracoscopic (VATS) lobectomy for non-small-cell lung cancer (NSCLC). Methods A retrospective study was conducted on the prospectively-maintained database in our institution between January 2015 and July 2017. The gender-specific median values of FFMI for males and females were applied as their respective cutoffs to stratify patients into low-FFMI group and high-FFMI group in initial univariable analyses. An effective multivariable logistic-regression analysis was then performed to demonstrate the predictive value of dichotomized FFMI. Results There were 1,091 surgical patients with NSCLC included (616 males and 475 females), with a PAL incidence of 14.6%. The median FFMI values among males and females were 17.3 and 14.6 kg/m2, respectively. PAL cases in both male (16.9±1.5 vs. 17.4±1.5 kg/m2; P=0.002) and female (14.0±0.9 vs. 14.6±1.1 kg/m2; P<0.001) groups had a significantly lower mean FFMI than that of non-PAL cases. The incidence of PAL was significantly increased in male patients with FFMI <17.3 kg/m2 (23.7% vs. 14.3%; P=0.003) and female patients with FFMI <14.6 kg/m2 (12.7% vs. 5.0%; P=0.003). Lower dichotomized FFMI was also significantly associated with prolonged time to air leak cessation and length of stay (LOS). Finally, multivariable logistic-regression analysis indicated that lower dichotomized FFMI [odds ratio (OR) =1.98; 95% confidence interval (CI): 1.33-2.96; P=0.001] could independently predict the occurrence of PAL. Conclusions FFMI acts as an excellent categorical risk factor for PAL complicating VATS lobectomy and shows a much superior significance than body mass index (BMI) in terms of the prediction of PAL.
Promoting enhanced patient and family caregiver congruence on lung cancer symptom experiences.

PURPOSE/OBJECTIVES To test the effects of different perspective-taking instructional sets, gender, caregivers' personal histories with cancer, and caregiving relationship factors on family caregiver and patient perceptual agreement of symptom experiences of patients with lung cancer. DESIGN Counterbalanced. SETTING Thoracic oncology outpatient clinical setting in Canada. SAMPLE 98 dyads consisting of patients with lung cancer and their family caregivers. METHODS Data were collected on a one-time basis by employing an abbreviated version of the Memorial Symptom Assessment Scale targeting lack of energy and worrying. Caregivers were randomized to one of six counterbalanced conditions of perspective-taking instructions. MAIN RESEARCH VARIABLES Caregiver discrepancy scores, instructional sets (i.e., neutral, self-report, and imagine-self and imagine-patient perspective-taking), order effects, gender, caregivers' personal history with cancer, and caregiving relationship factors. FINDINGS No order effects were found for the instructional sets. Instructions to imagine the patient's perspective over imagining how the caregiver would feel if he or she had cancer were most effective in enhancing the caregiver's ability to estimate the patient's lack of energy and worrying. Gender had no significant effects. The amount of patient-caregiver communication had a positive impact on the accuracy of caregivers' perspectives. CONCLUSIONS The patient-oriented instructions had a limited impact on enhancing patient-caregiver congruence on patient symptoms. This likely is related to the study's convenience sample of caregivers who appear to naturally engage in empathic processes of patient-oriented perspective-taking when they assessed and reported on patient symptom conditions. IMPLICATIONS FOR NURSING Further exploratory work should identify interpersonal conditions that negatively hamper the effects of caregiver perspective-taking on their reasonable understanding of patient symptoms.
Contribution of Brain Imaging to the Understanding Of Gait Disorders in Alzheimer’s Disease

Although gait disorders are common in Alzheimer’s disease (AD), determining which brain structures and related lesions are specifically involved is a goal yet to be reached. Our objective was to systematically review all published data that examined associations between gait disorders and brain imaging in AD. Of 486 selected studies, 4 observational studies met the selection criteria. The number of participants ranged from 2 to 61 community dwellers (29%-100% female) with prodromal or dementia-stage AD. Quantitative gait disorders (ie, slower gait velocity explained by shorter stride length) were associated with white matter lesions, mainly in the medial frontal lobes and basal ganglia. The nigrostriatal dopamine system was unaffected. Qualitative gait disorders (ie, higher stride length variability) correlated with lower hippocampal volume and function. Gait disorders in AD could be explained by a high burden of age-related subcortical hyperintensities on the frontal–subcortical circuits (nonspecific) together with hippocampal atrophy and hypometabolism (specific).
Differences in psychological and physical health among layoff survivors: the effect of layoff contact.

This study examined health and well-being among workers who have experienced varying types of contact with layoffs in an organization undergoing downsizing. Using survey data from a large organization employing both white- and blue-collar workers (N = 2,279), the authors argued that there are important differences among surviving workers as a function of their layoff experiences. Having any kind of personal contact with layoffs is found to be associated with less job security, more symptoms of poor health, depression, and eating changes as compared with having no layoff contact. Being laid off and rehired is associated with more work-related injuries and illnesses and missed work days due to such events than is receiving a "warn" notice, indirect contact (i.e., friends or coworkers laid off), or no contact with layoffs. Job security partially mediates the relationship between type of layoff contact experiences and health.
Transfer Student Resources: Keeping Students Once They Enroll

This descriptive study explored campus resources used by transfer students to understand ways institutions can better help them persist to graduation. Completed surveys from 257 transfer students indicated a number of programs and services that met this aim. The top three programs and services used at the current institution were the Computer Support Center, Career Services, and University Health Services. Recommended services included transfer programs, child care on campus, help with the transfer process, and advising. Themes students indicated that could help them graduate related to scheduling classes, personal life situations, enrolling in more credit hours, acceptance of more transfer credits, financial resources, advising, and offering transfer programs or workshops or support or activities. Implications and recommendation for institutions are also discussed.
Myocyte Enhancer Factor 2 and Chorion Factor 2 Collaborate in Activation of the Myogenic Program in Drosophila

ABSTRACT The process of myogenesis requires the coordinated activation of many structural genes whose products are required for myofibril assembly, function, and regulation. Although numerous reports have documented the importance of the myogenic regulator myocyte enhancer factor 2 (MEF2) in muscle differentiation, the interaction of MEF2 with cofactors is critical to the realization of muscle fate. We identify here a genomic region required for full MEF2-mediated activation of actin gene expression in Drosophila, and we identify the zinc finger transcriptional regulator chorion factor 2 (CF2) as a factor functioning alongside MEF2 via this region. Furthermore, although both MEF2 and CF2 can individually activate actin gene expression, we demonstrate that these two factors collaborate in regulating the Actin57B target gene in vitro and in vivo. More globally, MEF2 and CF2 synergistically activate the enhancers of a number of muscle-specific genes, and loss of CF2 function in vivo results in reductions in the levels of several muscle structural gene transcripts. These findings validate a general importance of CF2 alongside MEF2 as a critical regulator of the myogenic program, identify a new regulator functioning with MEF2 to control cell fate, and provide insight into the network of regulatory events that shape the developing musculature.
Ag/AgBr/WO(3).H(2)O: visible-light photocatalyst for bacteria destruction.

A new composite photocatalyst Ag/AgBr/WO(3). H(2)O was synthesized by reacting Ag(8)W(4)O(16) with HBr and then reducing some Ag(+) ions in the surface region of AgBr particles to Ag nanoparticles via the light-induced chemical reduction. Ag nanoparticles are formed from AgBr by the light-induced chemical reduction reaction. The Ag/AgBr particles are on the surface of WO(3). H(2)O and have irregular shapes with sizes varying between 63 and 442 nm. WO(3). H(2)O appears as flakes about 31 nm thick and 157-474 nm wide. The as-grown Ag/AgBr/WO(3). H(2)O sample shows strong absorption in the visible region because of the plasmon resonance of Ag nanoparticles in Ag/AgBr/WO(3). H(2)O. The ability of this compound to destroy E. coli and oxidize methylic orange under visible light was compared with those of other reference photocatalysts. Ag/AgBr/WO(3). H(2)O is a highly efficient photocatalyst under visible light. The Ag/AgBr/WO(3). H(2)O samples recovered from repeated photooxidation experiments are almost identical to the as-prepared samples, proving the stability of Ag/AgBr/WO(3). H(2)O sample.
The use of a radioimmunoassay for alpha‐fetoprotein in the diagnosis of malignancy

Using a double antibody radioimmunoassay test, α‐fetoprotein was elevated (i.e., over 40 ng/ml) in 72% of patients with hepatocellular carcinoma, 75% of patients with teratocarcinoma or embryonal cell carcinoma of the testis, 23% of patients with pancreatic carcinoma, 18% of patients with gastric carcinoma, 5% of patients with colonic carcinoma, and 7% of patients with bronchogenic carcinoma studied. In contrast to these positive findings in patients with cancer, none of the 210 normal controls over 1 year of age and only 1 of the 300 patients with chronic nonhepatic diseases other than ataxia telangiectasia had elevated levels. All of the 40 patients studied with the immunodeficiency disease, ataxia telangiectasia, had elevated AFP levels in accord with the view that these patients have a defect in organ differentiation. The radioimmunoassay for AFP was of special value in monitoring the effectiveness of therapy of certain forms of malignancy (e.g., hepatocellular carcinoma, embryonal cell carcinoma, and teratocarcinoma of the testis), since the product of a few tumor cells was detectable with this assay when AFP was undetectable as assessed by agar diffusion tests and when the residual tumor could not be detected by other clinical parameters.
Re: Bilateral same-day intravitreal injections using a single vial and molecular bacterial screening for safety surveillance.

evanescent white dot syndrome finding, without white dots. In addition, these typical foveal features come from disruption of the IS/OS photoreceptor line and can recover fully. Although the findings from this study was based only on a small case series, they demonstrated that optical coherence tomography should be considered as a useful test to diagnosis multiple evanescent white dot syndrome and that further studies are warranted.
Resting Metabolic Rate, Body Composition and Thyroid Hormones

27 obese women (relative body weight 191 +/- 27%), aged 35 +/- 11, underwent a 15 day very low calorie diet (VLCD: 1337 kJ/day). Mean body weight loss was 6 +/- 1.5 kg. Resting metabolic rate (RMR), measured by indirect calorimetry, showed a significant decrease both in absolute values (from 1793 +/- 225 to 1569 +/- 231 kcal/day; P less than 0.001), and in keal/kg body weight/day (from 17 +/- 2, to 16 +/- 2, P less than 0.001). Serum triiodothyronine (T3) significantly decreased from 1.1 +/- 0.2 to 1 +/- 0.2 microgram/1 (P less than 0.001). Before VLCD the differences between measured RMR and theoretical RMR (RMR-T) were not significant. After VLCD RMR values were significantly (P less than 0.001) lower than RMR-T. It was concluded that fat-free mass loss, combined with periferic thyroxin (T4) reduced monodeiodination in its more active form mainly due to low calorie intake T3 could be responsible for the important reduction observed in the resting metabolic rate.
Use of DNA fingerprinting and biotyping methods to study a Candida albicans outbreak in a neonatal intensive care unit

During a 15-day period, 7 premature infants hospitalized in a neonatal intensive care unit presented with sepsis caused by Candida albicans. The local environment and hands of all 54 persons involved in the intensive care unit were examined for the presence of this organism. Five techniques were used in the analysis in the analysis of the isolates recovered from blood cultures of the children, the hands of personnel and 10 control isolates. The methods used were serotype determination, genetic fingerprinting, morphotyping, resistotyping and killer yeast typing. Morphotyping and genetic fingerprinting proved to be the most discriminatory techniques, and only combined analysis of the results obtained with these various methods allowed the source of the outbreak to be identified. An isolate from the hands of a healthy staff member and isolates from infected children all belonged to the same strain.
Determination of Titanium and Vanadium in Ziegler-Natta Catalysts by Inductively Coupled Plasma Atomic Emission Spectrometry

A method for the determination of Ti and V using inductively coupled plasma atomic emission spectrometry (ICP OES) in Ziegler-Natta polymerization catalysts is proposed. The concentrations of both Ti and V are efficiently determined after catalyst acid digestion with a mixture of HNO_3 + HCl + HF and heating (160°C for 6 h) or with 10% (v/v) H_2SO_4and heating (160°C for 6 h) or with 10% (v/v) H_2SO_4 and sonication (during 2 min). The V and Ti detection limits are 0.002% and 0.08%, respectively, using 0.20 g of catalyst sample in 50 ml. The method is validated by a comparison with the Rutherford backscattering spectrometry (RBS) technique. In this case, catalyst samples are only pressed as pellets before analyte determination. Despite the fact that both the V and Ti concentrations cannot be determined individually by means of RBS, because the atomic numbers of Ti and V are very close, the sum of the V and Ti contents is in accordance with that attained by means of ICP OES. According to scanning electron microscopy-energy dispersive X-ray analysis (SEM-EDX) it is observed that the Ti distribution on the catalyst grain is not homogenous.
Comprar Histology: A Text and Atlas, 7ª Ed. With Correlated Cell And Molecular Biology | Michael H Ross | 9781469889313 | Lippincott Williams & Wilkins

Tienda online donde Comprar Histology: A Text and Atlas, 7a Ed. With Correlated Cell And Molecular Biology al precio 54,86 € de Michael H Ross | Wojciech Pawlina, tienda de Libros de Medicina, Libros de Anatomia - Atlas histologico
Severe Long‐Lasting Drought Accelerated Carbon Depletion in the Mongolian Plateau

Paleoclimate records identified a severe drought lasting approximately a decade on the Mongolian Plateau during the 2000s, the severity of which was only exceeded by a single drought during the last two millennia. Under high‐emission scenarios, arid and semiarid areas are projected to continue to experience a drying trend over the coming decades; therefore, understanding how ecosystems respond to long‐lasting drought has global implications. Here we used a process‐based ecosystem model to examine the interannual and intra‐annual variations in net ecosystem productivity in response to climate extremes across the Mongolian Plateau. We find that the recent‐decade drought caused Mongolian terrestrial ecosystems to shift from a carbon (C) sink to a C source, canceling 40% of climate‐induced C accumulation over the entire twentieth century. Our study details a shortened C sequestering season, increased summer C source, and accelerated C depletion during the 2000s drought.
Mechanism of Short Term Fe Reduction by Roots : Evidence against the Role of Secreted Reductants.

The hypothesized role of secreted reducing compounds in Fe(III) reduction has been examined with Fe-deficient peanuts (Arachis hypogaea L. cv A124B). Experiments involved the exposure of roots to (a) different gas mixtures, (b) carbonyl cyanide m-chlorophenylhydrazone (CCCP), and (c) agents which impair membrane integrity.Removing roots from solution and exposing them to air or N(2) for 10 minutes did not result in any accumulation in the free space of compounds capable of increasing rates of Fe(III) reduction when roots were returned to solutions. On the contrary, exposing roots to N(2) decreased rates of Fe(III) reduction. CCCP also decreased rates of Fe(III) reduction.Acetic acid and ethylenediaminetetraacetic acid (disodium salt) (EDTA) impaired the integrity and function of the plasma membranes of roots of Fe-deficient peanuts. That is, in the presence of acetic acid or EDTA, there was an efflux of K(+) from the roots; K(+) ((86)Rb) uptake was also impaired. Acetic acid increased the efflux from the roots of compounds capable of reducing Fe(III). However, both acetic acid and EDTA caused rapid decreases in rates of Fe(III) reduction by the roots. In addition to peanuts, acetic acid also decreased rates of Fe(III) reduction by roots of Fe-deficient sunflowers (Helianthus annuus L. cv Sobrid) but not maize (Zea mays L. cv Garbo). These results suggest that, at least in the short term, the enhanced Fe(III) reduction by roots of Fe-deficient plants is not due to the secretion of reducing compounds.
Strong Scattering of ∼keV Pickup Ions in the Local Interstellar Magnetic Field Draped around Our Heliosphere: Implications for the IBEX Ribbon's Source and IMAP

The leading hypothesis for the origin of the Interstellar Boundary Explorer(IBEX) “ribbon” of enhanced energetic neutral atoms (ENAs) from the outer heliosphere is the secondary ENA mechanism, whereby neutralized solar wind ions escape the heliosphere, and after several charge-exchange processes, may propagate back toward Earth primarily in directions perpendicular to the local interstellar magnetic field (ISMF). However, the physical processes governing the parent protons outside of the heliopause are still unconstrained. In this study, we compute the “spatial retention” model proposed by Schwadron & McComas in a 3D simulated heliosphere. In their model, pickup ions outside the heliopause that originate from the neutral solar wind are spatially retained in a region of space via strong pitch angle scattering before becoming ENAs. We find that the ribbon's intensity and shape can vary greatly depending on the pitch angle scattering rate both inside and outside the spatial retention region, potentially contributing to the globally distributed flux. The draping of the ISMF around the heliopause creates an asymmetry in the average distance to the ribbon's source as well as an asymmetry in the ribbon's shape, i.e., a radial cross section of ENA flux through the circular ribbon. The spatial retention model adds an additional asymmetry to the ribbon's shape due to the enhancement of ions in the retention region close to the heliopause. Finally, we demonstrate how the ribbon's structure observed at 1 au is affected by different instrument capabilities, and how the Interstellar Mapping and Acceleration Probe may observe the ribbon.
Differences in risk behaviours, HIV/STI testing and HIV/STI prevalence between men who have sex with men and men who have sex with both men and women in China

Differences in risk behaviours between men who have sex with men (MSM) and men who have sex with both men and women (MSMW) have important implications for HIV and sexually transmitted infection (STI) transmission. We examined differences in risk behaviours, HIV/STI testing, self-reported HIV/STI diagnoses, and linkage to HIV care between MSM and MSMW across China. Participants were recruited through three MSM-focused websites in China. An online survey containing items on socio-demographics, risk behaviours, testing history, self-reported HIV/STI diagnosis, and linkage to and retention in HIV care was completed from September to October 2014. Chi square tests and logistic regression analyses were conducted. MSMW were less likely to use a condom during last anal sex (p ≤ 0.01) and more likely to engage in group sex (p ≤ 0.01) and transactional sex (p ≤ 0.01) compared to MSM. Self-reported HIV/STI testing and positivity rates between MSM and MSMW were similar. Among HIV-infected MSM, there was no difference in rates of linkage to or retention in antiretroviral therapy when comparing MSM and MSMW. Chinese MSM and MSMW may benefit from different HIV and STI intervention and prevention strategies. Achieving a successful decrease in HIV/STI epidemics among Chinese MSM and MSMW will depend on the ability of targeted and culturally congruent HIV/STI control programmes to facilitate a reduction in risk behaviours.
[Expression patterns of E-cadherin and beta-catenin according to clinicopathological characteristics of hepatocellular carcinoma].

BACKGROUND/AIMS E-cadherin is involved in intercellular binding and cellular polarity formation. beta-catenin plays a fundamental role in regulation of the E-cadherin cell adhesion complex. The abnormalities of the components of the complex may disrupt this adhesive function. We investigated the expression patterns of E-cadherin and beta-catenin to determine the clinical significance of these proteins in hepatocellular carcinoma. MATERIALS/METHODS Thirty-six hepaticellular carcinoma tissues and adjacent non-tumor specimens were analyzed. Subcellular distribution of E-cadherin and beta-catenin was examined by immunohistochemistry staining. We evaluated the patterns of the expression, and investigated the relationship with the cause of HCC; level of AFP; TNM stage; tumor size; growth types; metastasis; differentiation grade of HCC; and presence of portal vein thrombosis. RESULTS Immunohistochemistry showed that all non-tumor tissues had membranous type staining of E-cadherin. All non-tumor tissues showed cytoplasmic type staining of beta-catenin, but no beta-catenin accumulation in nuclei was found. 58% (21/36) of HCC showed positive expression of E-cadherin in cytoplasmic membrane. The cytoplasmic expression of beta-catenin in HCC was 83% (30/36); nuclear expression in 14% (5/36); and no staining in 3% (1/36). Nuclear beta-catenin expression was observed in none (0/4) of the well-differentiated HCC; 17%(3/9) of moderate-differentiated HCC; and 17%(2/6) of poorly-differentiated HCC. There were no relationships between E-cadherin and beta-catenin expression with other clinicopathologic factors. CONCLUSIONS Loss of cytoplasmic staining of E-cadherin and nuclear accumulation of beta-catenin were observed in HCC. Nuclear accumulation of beta-catenin was not found in well differentiated HCC but was found in poorly differentiated HCC.