Miracle-dz/UniFAR-FTUs huggingface dataset:
A saúde dos idosos brasileiros às vésperas do século XXI: problemas, projeções e alternativas

Current characteristics and perspectives of Brazilian demographic and epidemiological transition processes are analyzed. Results from the 1991, 1993, 1995 and 1996 censuses, new population projections and recent studies on socioeconomic and health profiles of elderly people of S. Paulo, Rio de Janeiro and Belo Horizonte are discussed. In 1995, estimated life expectancy at birth in Brazil was already over 67 years. The number of individuals aged 60 years and older - in 1995, 8.3%, of the total population - is expected to duplicate and probably stabilize by the year 2050. Yet lacking coverage and quality, health services are already burdened with degenerative diseases and mental disorders, frequent out-patient appointments, high hospital bed occupation and high costs. Functional impairment and self-reported diseases are related to poverty among the elderly, for whom social and health support are not properly provided. Support from informal caregivers becomes more difficult due to impoverishment, family size reduction and youth migration. Institutionalization remains a poor approach as scarcity of beds and inadequacy of staff preclude its utilization. To minimize the impact of population aging on health services, it is proposed that effective programs covering the control of degenerative diseases and the prevention of their complications should be implemente - for the elderly population too. The importance of physical exercise, screening for neoplastic diseases, immunization, prevention of fractures caused by falls and early diagnosis of depression and dementia is emphasized. Actions must be coordinated by primary health care units, oriented towards local needs. It is essential to maintain the elderly in adequate, productive activities, invest in young people's education and health and in social and medical support programs for the caregivers.
Cross-over trials in clinical research

Preface to the Second Edition Preface to the First Edition 1. Introduction 2. Some Basic Considerations Concerning Estimation in Clinical Trials 3. The AB/BA Design with Normal Data 4. Other Outcomes and the AB/BA Design 5. Normal Data from Designs with Three or More Treatments 6. Other Outcomes from Designs with Three or More Treatments 7. Some Special Designs 8. Graphical and Tabular Presentation of Cross-over Trials 9. Various Design Issues 10. Mathematical Approaches to Carry-over References Author Index Subject Index
VOPRec: Vector Representation Learning of Papers with Text Information and Structural Identity for Recommendation

Finding relevant papers is a non-trivial problem for scholars due to the tremendous amount of academic information in the era of scholarly big data. Scientific paper recommendation systems have been developed to solve such problem by recommending relevant papers to scholars. However, previous paper recommendations calculate paper similarity based on hand-engineered features which are inflexible. To address this problem, we develop a scientific paper recommendation system, namely VOPRec, by vector representation learning of paper in citation networks. VOPRec takes advantages of recent research in both text and network representation learning for unsupervised feature design. In VOPRec, the text information is represented with word embedding to find papers of similar research interest. Then, the structural identity is converted into vectors to find papers of similar network topology. After bridging text information and structural identity with the citation network, vector representation of paper can be learned with network embedding. Finally, top-<inline-formula><tex-math notation="LaTeX">$Q$</tex-math><alternatives><mml:math><mml:mi>Q</mml:mi></mml:math><inline-graphic xlink:href="xu-ieq1-2830698.gif"/></alternatives></inline-formula> recommendation list is generated based on the similarity calculated with paper vectors. Through the APS data set, we show that VOPRec outperforms state-of-the-art paper recommendation baselines measured by precision, recall, F1, and NDCG.
Harmonic current control in a high-power current source rectifier system

Line current distortion is an important issue to a high-power current source rectifier (CSR) system. There are two main challenges related to this issue. First, the CSR input LC resonance can be affected by the varia tion of the source inductance from the power system and the effects of the CS R DC side circuit, which may lead to a line current distortion higher than expected. Another challenge is that the traditional high-power CSR using Selective Harmonic Elimination ( SHE) pulse-width modulation (PWM) technique attempts to eliminate certain harmonics in the PWM current, which limits its ab ility for line current harmonic control. To control the CSR line cur rent harmonics, t his thesis focuses on two aspects : 1) the analys is and design of CSR input filter to avoid unexpected input LC resonance , and 2) the development of a new PWM scheme that can compensate the effects of the grid voltage harmonics and DC link current ripples . The thesis work has been validated by simulation s and on an experimental CSR prototype .
Enabling Empowerment: Using Simulations versus Real Occupations

This study shows how the organization of occupational therapy determines occupational therapists' potential and limits for enabling the empowerment of adults who attend mental health day programmes. Drawing from the full ethnography, this paper shows how the organization of practice determines invisibly whether occupational therapists are more likely to involve people in simulations or in the real occupations of their everyday world. The study explores the use of simulations versus real occupations by tracing everyday practice to the locations, facilities, and scheduling context in which practice occurs. Practice is further traced to the philosophic and funding context of programmes. The final part of the analysis outlines how the use of simulations versus real occupations is shaped by particular ideas about mental health, professional practice, health services, welfare, and the market place. The analysis of an institutional ethnography offers a blueprint for change.
A Key Distribution and Management Scheme for Clustered Ad Hoc Sensor Networks

Presently, the most practical approach for bootstrapping initial secret keys in sensor networks is to load keys into sensor nodes before they are deployed. However, some of them are vulnerable to impersonation attacks. We describe a novel key distribution and management scheme for clustered ad hoc sensor networks. The scheme uses the Boneh-Franklin’s ID-based encryption (IBE) scheme and Yi’s ID-based signature scheme to achieve mutual authentication between nodes. The signature scheme is used to distribute a cluster key which can be updated. We also derive a master key from the signature which can also be updated when needed. Our contribution is that we resolved the impersonation problems that exist in current key distribution schemes for ad hoc sensor networks. A timestamp is incorporated in the signing procedure, avoiding message replay attacks. Finally, This scheme can be extended to hierarchical ad hoc sensor networks.
Hematopoietic Stem Cell Transplantation in PML-RARa Positive Acute Promyelocytic Leukemia

Introduction: Acute promyelocytic leukemia treatment revolutionized by new tretaMNETS. Currently number of patinets who undergoe hematopoietic stem cell transplantation decrased so experience with this modality is limited. Here we report our experience with stem cell transplantation in acute promyelocytic leukemia patients. Design and setting: retrospective, single center Methods: between year 2000 and 2011 we performed 20 HSCT in APL. Median age of patients was 25 year old. Patients received 3 autologous and 17 allogeneic HSCT from their HLA full match sibling donor. Different type of conditioning regimens applied for them. We used Cyclosporine and Methotraxtae as prophylaxis of GVHD after allogeneic HSCT. Results: Hematopoietic stem cell engraftment observed in all cases. Acute GVHD was mild to moderate in all except one and was manageable.one patient dies due to aGVHD. Chronic GVHD was extensive in 2 cases and one mortality observed due to sever cGVHD. Mortality rate was 35% with a median follow up of 3.5 years. Five patinets died due to their primary disease relapse after HSCT. Three years DFS and OS were 63.1 and 77.2% respectively. Conclusion: hematopoietic stem cell transplantation is an acceptable consolidation for APL. Choosing between autologous or allogeneic transplantation, need facilities such as reliable method for molecular remission detection before HSCT and also close and reliable follow up of patients with clinical and molecular parameters.
Evidence Scan of Work Experience Programs

This report presents evidence on the effectiveness of interventions that include work experience as a strategy to improve employment outcomes for people with barriers to employment. The report reviews 26 years of rigorous research gathering information from 27 evaluations. The author distinguishes between interventions targeting adults versus youth, paid versus unpaid work, and length of work opportunity.
The time course of working memory effects on visual attention

Previous work has generated inconsistent results with regard to what extent working memory (WM) content guides visual attention. Some studies found effects of easy to verbalize stimuli, whereas others only found an influence of visual memory content. To resolve this, we compared the time courses of memory-based attentional guidance for different memory types. Participants first memorized a colour, which was either easy or difficult to verbalize. They then looked for an unrelated target in a visual search display and finally completed a memory test. One of the distractors in the search display could have the memorized colour. We varied the time between the to-be-remembered colour and the search display, as well as the ease with which the colours could be verbalized. We found that the influence of easy to verbalize WM content on visual search decreased with increasing time, whereas the influence of visual WM content was sustained. However, visual working memory effects on attention also decreased when the duration of visual encoding was limited by an additional task or when the memory item was presented only briefly. We propose that for working memory effects on visual attention to be sustained, a sufficiently strong visual representation is necessary.
Vacina BCG: eficácia e indicações da vacinação e da revacinação

OBJETIVOS: Revisar aspectos relacionados ao efeito protetor da primeira e segunda doses da vacina BCG e discutir as suas principais indicacoes e contra-indicacoes. FONTES DOS DADOS: Utilizando o PubMed, foi realizada uma revisao sistematica da literatura abrangendo um periodo de, aproximadamente, 50 anos. Os estudos foram agrupados por tipo de desenho, apresentando-se separadamente os principais resultados de ensaios clinicos, estudos de caso-controle e meta-analises. Outros topicos relevantes, como a BCG e HIV/AIDS, o uso do teste tuberculinico, aspectos relacionados a cicatriz vacinal e ao desenvolvimento de novas vacinas, dentre outros, foram tambem revistos. SINTESE DOS DADOS: A vacina BCG e utilizada desde 1921. Apesar disso, ainda apresenta controversias e aspectos nao esclarecidos. O efeito protetor da primeira dose da vacina BCG contra a tuberculose na forma miliar ou na meningite e bastante significativa. No entanto, em relacao a forma pulmonar, os resultados sao discordantes, variando de ausencia de efeito a niveis proximos a 80%. Ha evidencias de que uma segunda dose da BCG nao aumenta o seu efeito protetor. Estudos demonstram protecao da vacina contra a hanseniase. Pesquisas sobre novas vacinas que, no futuro, poderao vir a substituir a BCG estao sendo realizadas. CONCLUSOES:Apesar da expectativa de que, no futuro, venhamos a ter uma nova vacina para a tuberculose, no presente e ainda por muitos anos, a vacina BCG, apesar de suas deficiencias, mantem-se como um importante instrumento nos esforcos para controle dos efeitos danosos da tuberculose, sobretudo em paises em que essa doenca ocorre em medias e elevadas taxas de incidencia.
Sargassum muticum (Yendo) Fensholt sur le littoral français. Synthèse des actions entreprises de 1984 à 1989

L'algue Phaeophyceae Sargassum muticum (Yendo) Fensholt est originaire des cotes japonaises du Pacifique (Fensholt, 1955) ou elle constitue des peuplements peu denses, en mode semi-battu a calme, dans l'infralittoral superficiel. Elle a considerablement etendu son aire de repartition, en partie grâce au vecteur que constitue le naissain d'huitre japonaise Crassostrea gigas (Thunberg). A l'heure actuelle, sa repartition mondiale concerne, en dehors des cotes du Japon, de Chine et de Coree, la cote Ouest l'Amerique du Nord, de Vancouver au Nouveau Mexique (Norton, 1981), les cotes atlantiques de l'Europe et la Mediterranee occidentale francaise. (fig. 1) Comme le laissaient prevoir les travaux de Knoeffler Peguy et al. (1985) et d'Haroun Tabrane et al., (1985) elle a atteint les cotes espagnoles des 1985 (Pascual C.C., 1987). Europe, Sargassum muticum est signalee pour la premiere fois en 1973 a Wight, sur cotes anglaises de la Manche (Farnham, 1974); en 1975 elle est observee du cote francais de la Manche, a St-Vaast-La-Hougue (Cosson et al., 1977) ; elle a ensuite atteint la Belgique (Cappe jans et al., 1980) et les Pays-Bas (Nienhuis, 1982). En France, sa progression a ete facilitee par les schemas de commercialisation du naissain d'huitre (Gruet, 1983 ; Belsher et al., 1985) entre les grands centres d'exploitation ostreicole, notamment ceux du Cotentin Ouest, de la baie de Morlaix, des Abers, d'Arcachon, de Marennes-Oleron et de l'etang de Thau).
White wines countering the metabolic syndrome

Aim is to evaluate effectiveness of white wines as a part of medical rehabilitation in arterial hypertension (AH) patients with metabolic syndrome (MS). Material and Methods — Analysis of effectiveness of table dry white wine “Rkatsitely Alma” (RA) and liquor white wine “Madera Alma” (MA) as parts of the spa resort treatment, was carried out in group of 163 patients with AH. The comparison of wine effects was provided in groups of 60 patients with MS and 103 patients without MS. All patients received standard treatment and 60 patients additionally received white wine RA or MA. Methods of investigation included an assessment of functional state of the leading physiological systems by 20 domains of International Classification of Functioning, Disability and Health (ICF). Results — In patients with MS in main group (with wine consumption) the domain dynamics demonstrate more beneficial changes in comparison with control group. In particular, with respect to ICF domains b2401 “Dizziness”, b410 “Heart functions”, b4100 “Heart rate”, b4301 “Oxygen-carrying functions of the blood”, b455 “Exercise tolerance functions” and b4551 “Aerobic capacity”. Although ethanol and polyphenolic compounds of wine activity are comparable, their effects vary. We can see synergistic positive activity of ethanol and polyphenols in regard to 3 ICF domains (b2401 “Dizziness”, b4301 “Oxygen-carrying functions of the blood” and b455 “Exercise tolerance functions”). Synergistic negative activity of ethanol and polyphenols we can see in regard to 1 ICF domain (b4303 “Clotting functions”). There is independent negative activity of polyphenols in MS patients in regards to 2 ICF domains (b420 “Blood pressure functions” and b5408 “General metabolic functions, other specified –MS”). In patients without MS independent negative activity of ethanol was observed in regard to ICF domain b420 “Blood pressure functions”. In patients with MS consumption of MA induced some more beneficial effects (including ICF domains b420 “Blood pressure functions”, b5408 “General metabolic functions, other specified – MS” and b540 “General metabolic functions”) and some less beneficial effects (including ICF domains b2401 “Dizziness”, b28010 “Pain in head and neck” and b455 “Exercise tolerance functions”), than consumption of RA. A lot of beneficial effects of syringic (lilac) acid were observed in patients with MS. Conclusion — The moderate consumption of white wines can be recommended to AH patients with MS in a greater extent than to patients without this syndrome.
Weed Control in Narrow and Wide-Row Soybeans

Field studies were conducted over a 3-yr period to evaluate weed control systems for soybeans [Glycine max (L.) Merr. ] grown in 18- and 76-cm rows. Combinations of herbicides satisfactorily controlled a broad spectrum of annual grass and broadleaf weeds in soybeans grown in 76-cm rows with cultivation and in 18-cm rows without cultivation. Where a single herbicide treatment was used to control only annual grasses, the 76-cm rows (which were cultivated once) yielded from essentially the same as 18-cm rows up to almost 50% more than the 18-cm rows, which received no cultivation, depending on the year and broadleaf weed infestation. However, where herbicide combinations were used to effectively control all weeds, soybeans in 18-cm rows averaged up to 9% higher yields than those in the 76-cm rows.
Adding ecological and evolutionary processes to restoration biodiversity offset models using neutral theory

Biodiversity offsets are being implemented or planned across all continents and biogeographical realms. Due to their popularity, new offset projects have developed faster than empirical evidence of their ecological effectiveness, so policy has been informed by quantitative models. However, these models have yet to incorporate ecological and evolutionary processes, which vary globally. Here we use the unified neutral theory of biodiversity to integrate speciation and dispersal into models of restoration biodiversity offsets.
Understanding patients' adherence to antiretroviral therapy: A mixed-methods study in Arusha, Tanzania

Background: Adherence to antiretroviral therapy (ART) is essential for clinical success among people living with HIV. The objective of this study was to determine the level of ART adherence and the factors associated with poor adherence among a convenience sample taken from a population of patients receiving free ART at one clinic in Tanzania. Methods: Adult patients taking ART for at least one month were recruited into the crosssectional study from a single clinic in Arusha, Tanzania. Self-reported adherence over four days and one month were assessed by structured patient interviews. Patients who reported less than 95% on either of the measures were considered to have poor adherence. In addition to demographic and treatment variables, the following potential correlates of ART adherence were measured: perceived quality of patient-provider interaction, social support, perceived HIV stigma, self-efficacy to adhere, depression, number of people to whom patients had disclosed their HIV status, personal beliefs about ART, normative beliefs about ART, and perceived side effects. Factors associated with adherence in unadjusted analyses (α=0.10) were considered in a logistic regression model in forward stepwise fashion. Results: A total of 340 patients participated in the study. Only 5.9% (20/340) of respondents reported less than 95% adherence in either the previous four days or one month. The final logistic regression model included the following factors significantly associated with poor adherence: being young (19-30 years old, vs. 31-40 years old; OR=4.26, 95% CI 1.33-13.60);
Phase 2 study of pembrolizumab (pembro) monotherapy for previously treated metastatic triple-negative breast cancer (mTNBC): KEYNOTE-086 cohort A.

1008Background: In KEYNOTE-012, pembro showed durable activity and manageable safety in patients (pts) with PD-L1+ mTNBC. Cohort A of KEYNOTE-086 (NCT02447003) examined the efficacy/safety of pembro in previously treated mTNBC, regardless of PD-L1 expression. Methods: Pts with centrally confirmed mTNBC, ≥1 prior chemotherapy for metastatic disease, and ECOG PS 0-1 had pembro 200 mg Q3W for up to 24 mo; imaging q 9 wk for the first 12 mo, then q 12 wk. Clinically stable pts with PD could remain on pembro until PD confirmed on next assessment. Primary endpoints: ORR (RECIST v1.1, central review) in all pts and pts with PD-L1+ tumors, and safety. Secondary endpoints: DOR, disease control rate (DCR; CR + PR + SD ≥24 wk), PFS, and OS. Planned enrollment was 160 pts; analysis based on data as of Nov 10, 2016. Results: 60% of screened PD-L1-evaluable pts had PD-L1+ tumors (combined positive score ≥1%). Of 170 pts enrolled (100% women; median age 54 y), 44% had ≥3 prior lines of therapy, 51% had elevated LDH, 74%.
Library World Wide Web Sites at Medium-Sized Universities

ABSTRACT This article presents the results of a second survey of World Wide Web sites for 133 academic libraries serving medium-sized universities. Each Web site was visited, and all of the features were recorded. The study identified 42 core components which were present in over 50 percent of the libraries surveyed. The results of the survey were compared with an identical survey conducted three years earlier. The changes in the Web sites during that period were identified.
Neoadjuvant atezolizumab in resectable non-small cell lung cancer (NSCLC): Interim analysis and biomarker data from a multicenter study (LCMC3).

8503 Background: Small pilot studies (e.g., N Engl J Med. 2018;378:1976) have shown that preoperative immune checkpoint inhibitor therapy may be of benefit in early-stage NSCLC. This large multicenter trial assesses the benefit of neoadjuvant treatment with atezolizumab (atezo; NCT02927301). Methods: Patients (pts) with stages IB to selected IIIB resectable NSCLC receive 2 cycles of atezo 1200 mg (days 1, 22) then undergo resection (day 40 ± 10). Primary tumor +/- node biopsies and blood samples are obtained before atezo and at surgery for biomarker studies. The primary endpoint is major pathological response (MPR), defined as ≤ 10% viable tumor cells in the resection specimen. Secondary endpoints include safety and correlation of response with PD-L1 expression, tumor mutation burden (TMB) and gene expression signatures. Results: For this interim efficacy analysis (5 Sep 2018 data cut), we report on the first 101 of 180 planned pts: 47 males, median age, 64 y; all ECOG PS 0-1; 23 current and 68 former smokers; 66 non-squamous NSCLC; clinical stages IB/IIA/IIB/IIIA/IIIB n = 11/16/28/39/7. There were 2 treatment-unrelated Gr 5 AEs (cardiac death post surgical resection; death due to disease progression), 29 Gr 3-4 AEs (6 [6%] treatment related). 90 pts had surgery. Excluding 8 pts who had driver mutations (7 EGFR, 1 ALK, no MPR), MPR rate was 15/82 (18%, 95% CI 11%-28%), 4 pts had pathological complete response (pCR). By RECIST, 6/82 pts had PR, 72 had SD and 4 had PD. Two of 26 (8%) PD-L1− (TC0 and IC0, clone SP142) and 10 of 35 (29%) PD-L1+ had MPR ( P= 0.055). Five of 44 (11%) TPS < 50 (PD-L1 clone 22C3) and 7 of 20 (35%) TPS > 50 had MPR ( P= 0.040). Exome sequencing data was available for 47/101 pts. Median TMB was 10.4 (range, 1.5-46.5) mutations per Mb and was not different in those with MPR compared with those without MPR. Further analysis of TMB, mutation signatures, and gene expression profiling is ongoing. Conclusions: Atezo in the neoadjuvant setting was well tolerated, and pCR and MPR rates are encouraging in this large multicenter trial. Efficacy interim analysis passed its futility boundary, and study enrollment continues. Safety, efficacy results and ongoing correlative analyses will be presented. Clinical trial information: NCT02927301.