Miracle-dz/UniFAR-FTUs huggingface dataset:
Preoperative and postoperative topical tretinoin on high-tension excisional wounds and full-thickness skin grafts in a porcine model: A pilot study.

BACKGROUND Tretinoin induces neovascularization and the formation of collagen when applied topically. OBJECTIVE The goal was to determine whether preoperative and postoperative treatment with tretinoin enhances the healing of high-tension, full-thickness excisional wounds and the survival of full-thickness skin grafts. METHODS A blinded, randomized, placebo-controlled pilot study involved high-tension excisional wounds and full-thickness skin grafts treated perioperatively with tretinoin in a porcine model. RESULTS Perioperative treatment of high-tension excisional surgery sites with tretinoin appeared to have no consistent beneficial or adverse effects on wound healing or scar spreading. In the full-thickness skin graft model, a trend toward impaired wound healing was noted. CONCLUSION The collagen-inducing effects of topical tretinoin do not appear to enhance the healing of high-tension excisional surgery wounds in a porcine model. Tretinoin does not appear to improve the survival of full-thickness skin grafts and, in fact, a detrimental effect was apparent in our model.
Investigating the implementation and impact of participation in a health promotion programme on the social attitudes and behaviours of children in New Zealand schools

ii Dedication iv Acknowledgments v List of Tables xii List of Figures xv CHAPTER 1: INTRODUCTION 1.1 Child social health 1 1.2 The situation in New Zealand 2 1.3 Significance of research 6 1.4 Background to research 7 1.5 Assumptions 8 1.6 Structure of thesis 8 CHAPTER 2: LITERATURE REVIEW 2.
Effect of Metabolic Acidosis on the Potassium Content of Bone

Metabolic acidosis induces resorption of cultured bone, resulting in a net efflux of calcium (Ca) from the bone and an apparent loss of mineral potassium (K). However, in these organ cultures, there is diffusion of K between the medium and the crystal lattice, causing difficulty in interpretation of the acid‐induced changes in mineral ion composition. To determine the effects of acidosis on bone mineral K, we injected 4‐day‐old neonatal mice with pure stable isotope41K, equal to ∼5% of their total body K. Calvariae were dissected 24 h later and then cultured for 24 h in medium without added41K, either at pH ∼7.4 (Ctl) or at pH ∼7.1 (Ac), with or without the osteoclastic inhibitor calcitonin (3 × 10−9 M, CT). The bone isotopic ion content was determined with a high‐resolution scanning ion microprobe utilizing secondary ion mass spectrometry.41K is present in nature at 6.7% of total K. The injected41K raised the ratio of bone41K/(39K+41K) to 9.8 ± 0.5% on the surface (ratios of counts per second of detected secondary ions, mean ±95% confidence interval) but did not alter the ratio in the interior (6.9 ± 0.4%), indicating biological incorporation of the41K into the mineral surface. The ratios of41K/40Ca on the surface of Ctl calvariae was 14.4 ± 1.2, indicating that bone mineral surface is rich in K compared with Ca. Compared with Ctl, Ac caused a marked increase in the net Ca efflux from bone that was blocked by CT. Ac also induced a marked fall in the ratio of41K/40Ca on the surface of the calvariae (4.3 ± 0.5, p < 0.01 vs. Ctl), which was partially blocked by CT (8.2 ± 0.9, p < 0.01 vs. Ctl and vs. Ac), indicating that Ac causes a greater release of bone mineral K than Ca which is partially blocked by CT. Thus, bone mineral surface is rich in K relative to Ca, acidosis induces a greater release of surface mineral K than Ca, and osteoclastic function is necessary to support the enriched levels of surface mineral K in the presence of acidosis.
An International Comparison of Factors Inhibiting Physicians' use of Hospital Information Systems

Finding ways to strengthen health care systems is a matter of great concern all around the world. Health care operations struggle with limited resources and diminishing workforce capabilities, making it imperative for effective and efficient operations. Hospital information systems (HIS) can help achieve this mission, providing reliable, timely, and relevant information about patient characteristics, reimbursement, and status of tests and quality metrics. However, there are still barriers toward the adoption of HIS by health care professionals. This study explores the inhibitors perceived by physicians for adopting HIS. The main motivation for this research is to answer the question: "What are the factors inhibiting physicians' use of Hospital Information Systems? " This research question is of great interest as physicians are considered to be the key to successful HIS deployment, adoption and use. This study takes a qualitative research approach, employing ninety-eight (98) interviews at nine different hospitals, complemented by more than 40 hours of workplace shadowing. We conducted our research in the United States, Chile and Germany, as the three countries have developed healthcare systems but take different approaches to fostering the use of IT in hospitals and have implemented at different organizational levels. Our findings show that the alignment of user, system and process is important as expected. However, the results point out that leadership and organizational setting play vital roles, although they were often neglected in previous studies.
Gas to Particle Partitioning of Organic Acids in the Boreal Atmosphere

Gas to particle partitioning of carboxylic acids was investigated using a high-resolution chemical ionization time-of-flight mass spectrometer (HR–CI–ToF–MS) with the filter inlet for gases and aerosol (FIGAERO). Specifically, the partitioning coefficients of 640 components with unique molecular composition were calculated from an assumed linear relationship between [particle]/[gas] versus the mass of the organic fraction (Morg) according to Raoult’s law, i.e., equilibrium phase partitioning. We demonstrate that, using the full data set, most of the compounds do not follow a linear relationship. This is especially the case for low- and high-molecular-weight species. Using a subset of the data, with concurrent low sulfate ambient observations ([SO42– < 0.4 μg m–3), the relationship improved significantly and Ki could be derived from the slope of a linear regression to the data. The 100 species with the highest R2 (≥0.7) of this regression are presented. The restrictions during high sulfate conditions can b.
Does ‘Cochlear Ménière’s Disease’ Exist? An Electrocochleographic and Audiometric Study

Introduction: According to current diagnostic criteria, patients exhibiting only cochlear symptoms without vertigo cannot be diagnosed with Ménière’s disease (MD). The recently reported Ménière’s Disease Index (MDI) combines audiometric and electrocochleographic parameters in a multidimensional measure correlating with the clinical degrees of MD. Materials and Methods: Twenty-one patients with hearing loss, tinnitus and aural fullness, but without vertigo, underwent transtympanic electrocochleography. Based on the previously reported formula, the MDI value for every patient was calculated. Results: Mean MDI value was 5.7 on a scale from 0 (mean value of non-MD patients) to 10 (mean value of definite MD patients). Conclusions: We can thus hypothesize that, based on audiometry and electrocochleography, ‘cochlear MD’ patients may represent a separate clinical entity with Ménière-like pathophysiology or underlying endolymphatic hydrops.
FOREST SEQUESTRATION: PERFORMANCE IN SELECTED COUNTRIES IN THE KYOTO PERIOD AND THE POTENTIAL ROLE OF SEQUESTRATION IN POST-KYOTO AGREEMENTS

This report examines the rational and potential for the use of forests for carbon sequestration in the context of the Kyoto Protocol. It looks at the role that sustainable forest management might play and at progress made thus far in utilizing forests to sequester carbon under the existing Kyoto arrangement. It also focuses on the approaches, progress, and problems of the European Union, Japan, and Canada in using forestry to move toward their Kyoto targets. Additionally, this report begins to think systematically about the issues that might need to be addressed in the post-Kyoto world and what types of international arrangements might be most useful in responding to a continuing climate problem, with particular attention paid to the role of biological carbon sequestration under various arrangements. This approach includes a discussion of the mechanisms of the Kyoto Protocol for forest sequestration and possible extensions of forestry activities for carbon sequestration under this and subsequent international agreements. The report also examines the implications of some hypothetical scenarios of future Kyoto-type arrangements on the role of forest carbon sequestration in addressing climate change.
Autoimmune response to the spliceosome. An immunologic link between rheumatoid arthritis, mixed connective tissue disease, and systemic lupus erythematosus.

OBJECTIVE To assess the significance of autoantibodies to RA33, the A2 protein of the heterogeneous nuclear ribonucleoproteins (hnRNP), and to the related hnRNP proteins A1, B1, and B2 in rheumatic diseases. METHODS Using a partially purified preparation of hnRNP-A and hnRNP-B proteins, sera from 303 patients with various rheumatic diseases were investigated by immunoblotting. For the analysis of cross-reactivities, autoantibodies were affinity purified by blot elution. RESULTS Anti-A2/RA33 was found in 35% of rheumatoid arthritis (RA) patients, 38% of mixed connective tissue disease (MCTD) patients, 23% of systemic lupus erythematosus (SLE) patients, and, apart from single exceptions, not in patients with other rheumatic diseases. All anti-A2/RA33-positive sera were also reactive with B1 and B2, and anti-A2/RA33 antibodies cross-reacted with both proteins. Antibodies to hnRNP-A1 were found less frequently; moreover, the majority of anti-A1-positive sera also contained anti-A2/RA33 antibodies. In anti-A1, anti-A2/RA33 double-positive sera, cross-reactivity between the 2 antibodies was generally observed. In SLE patients, the presence of anti-A2/RA33 was correlated with the presence of anti-(U1) small nuclear RNP (snRNP) and anti-Sm (P < 0.0001 and P < 0.005, respectively), but there was no evidence for cross-reactivity between antibodies to hnRNP and antibodies to snRNP antigens. CONCLUSION Since both hnRNPs and snRNPs are essential components of the spliceosome, the data show that the immune systems of patients with RA, SLE, and MCTD react to this functional complex. However, compared with MCTD and SLE patients, RA patients have a more restricted immune response to the spliceosome: they react to hnRNP proteins, particularly to hnRNP-A2/RA33, but not to snRNPs.
Use of mobile phone cameras for after-hours triage in primary care

Mobile phone images might be useful in after-hours triage of primary care. We conducted a study to identify population access to mobile phone cameras and to assess the clinical usefulness of mobile phone cameras. The survey was conducted among 480 patients attending two rural New Zealand practices. There were significantly more Maori owners compared to non-Maori (P = 0.002). Age was a significant factor influencing the ownership of mobile phones. We also conducted a clinical quiz among health professionals to assess how the provision of images on a mobile phone and on CD-ROM (to simulate the image that would be seen if email was used to transmit the images) influenced diagnostic confidence. Ten photographable clinical conditions were used to quiz 30 health professionals who were randomized into three groups of 10 each on diagnostic confidence. Images were found to significantly increase diagnostic confidence in all cases except one. It appears that mobile phone cameras are generally acceptable to patients and likely to be of practical use to rural practitioners in a range of clinical scenarios.
Genetic and biochemical analysis of Salmonella typhimurium FliI, a flagellar protein related to the catalytic subunit of the F0F1 ATPase and to virulence proteins of mammalian and plant pathogens

FliI is a Salmonella typhimurium protein that is needed for flagellar assembly and may be involved in a specialized protein export pathway that proceeds without signal peptide cleavage. FliI shows extensive sequence similarity to the catalytic beta subunit of the F0F1 ATPase (A. P. Volger, M. Homma, V. M. Irikura, and R. M. Macnab, J. Bacteriol. 173:3564-3572, 1991). It is even more similar to the Spa47 protein of Shigella flexneri (M. M. Venkatesan, J. M. Buysse, and E. V. Oaks, J. Bacteriol. 174:1990-2001, 1992) and the HrpB6 protein of Xanthomonas campestris (S. Fenselau, I. Balbo, and U. Bonas, Mol. Plant-Microbe Interact. 5:390-396, 1992), which are believed to play a role in the export of virulence proteins. Site-directed mutagenesis of residues in FliI that correspond to catalytically important residues in the F1 beta subunit resulted in loss of flagellation, supporting the hypothesis that FliI is an ATPase. FliI was overproduced and purified almost to homogeneity. It demonstrated ATP binding but not hydrolysis. An antibody raised against FliI permitted detection of the protein in wild-type cells and an estimate of about 1,500 subunits per cell. An antibody directed against the F1 beta subunit of Escherichia coli cross-reacted with FliI, confirming that the proteins are structurally related. The relationship between three proteins involved in flagellar assembly (FliI, FlhA, and FliP) and homologs in a variety of virulence systems is discussed.
Does Antidepressant Adherence Have an Effect on Glycemic Control among Diabetic Antidepressant Users?

Objective: To examine the relationship between adherence to antidepressant medications and HbA1c levels among patients with diabetes in a managed care setting. Method: The analysis included measures of HbA1c levels before, during, and after initial antidepressant use among 568 patients with diabetes enrolled in the Harvard Pilgrim Health Care insurance plan from 1991–1995. Adherence was defined as four refills in a six-month period after the first antidepressant prescription. General linear models using SAS PROC MIXED were used to estimate the effects of covariates including antidepressant adherence on HbA1c levels over time, comparing patients who were adherent to antidepressant medications to those patients who were non-adherent to antidepressant medications. Results: Adherence to antidepressant treatment was not significantly associated with HbA1c levels among diabetic patients who are antidepressant users. Younger age, use of insulin and oral medications, and female gender were all significantly associated with HbA1c levels over time. Conclusions: Although we did not observe any association between level of adherence to antidepressant therapy among diabetic patients and levels of glucose control, our results confirm previously established associations between patient characteristics and glycemic control. Further research is needed to disentangle the complex relationship among antidepressant treatment adherence and diabetes outcomes.
Evaluation of bone marrow reticulin in patients with chronic immune thrombocytopenia treated with eltrombopag: Data from the EXTEND study

Thrombopoietin receptor agonists, which raise platelet counts in patients with chronic immune thrombocytopenia, may be associated with increases in bone marrow (BM) reticulin. Patients with chronic immune thrombocytopenia participating in the Eltrombopag Extended Dosing (EXTEND) study underwent BM biopsies to identify clinically relevant BM fibrosis‐related increases. Specimens were centrally reviewed by 2 hematopathologists. Two hundred thirty‐two biopsy specimens were collected from 117 patients treated for ≤5.5 years. Moderate to marked reticulin fibrosis was found in 2 patients. After withdrawing from the study, the biopsy of 1 patient reverted to normal. There were no other pathologic changes identified among on‐treatment specimens, and no pattern of abnormal reticulin deposition associated with eltrombopag treatment was evident. Am. J. Hematol. 90:598–601, 2015. © 2015 Wiley Periodicals, Inc.
An Investigation into the Attitudes of Archivists towards the Use of Social Media at Archives New Zealand

Research problem: The purpose of this case study was to identify the attitudes of reference archivists at Archives New Zealand towards the use of social media. Analysis of the results aimed to determine whether attitudes expressed were affecting the organization’s current use of social media. Methodology: Thematic analysis was employed to identify themes of attitudes expressed by the archivists during semi-structured interviews. In turn content analysis was undertaken to determine Archives New Zealand’s current use of social media. Results: Analysis of the data showed that archivists were able to see the opportunities that the use of social media could bring. Although some concerns were expressed the overall impression given that it would be used in future but first a strategic plan need be put in place. Implications: Although results provide some insight, as a relatively small study it would be beneficial for further research to be undertaken. Additionally, a similar study of user attitudes would provide a more balanced view of the use of social media at Archives New Zealand.
The syntactic positive shift (sps) as an erp measure of syntactic processing

Abstract This paper presents event-related brain potential (ERP) data from an experiment on syntactic processing. Subjects read individual sentences containing one of three different kinds of violations of the syntactic constraints of Dutch. The ERP results provide evidence for M electrophysiological response to syntactic processing that is qualitatively different from established ERP responses to semantic processing. We refer to this electro-physiological manifestation of parsing as the Syntactic Positive Shift (SPS). The SPS was observed in an experiment in which no task demands, other than to read the input, were imposed on the subjects. The pattern of responses to the different kinds of syntactic violations suggests that the SPS indicates the impossibility for the parser to assign the preferred structure to an incoming string of words, irrespective of the specific syntactic nature of this preferred structure. The implications of these findings for further research on parsing are discussed.
Annual Conference of the International Association for Conflict Management

뀀ഀȠ 뀀ഀȠ 뀀ഀȠ The International Association for Conflict Management (IACM) was founded to encourage scholars and practitioners to develop and disseminate theory, research, and experience that are useful for understanding and improving conflict management in organizational, societal, family, and international settings. We invite papers as well as proposals for symposia and workshops for the 2013 meeting of IACM to be held in Tacoma, Washington.
Relationship Between Smartphone Addictions with Sleep Quality in Adolescents

The purpose of this study was to determine the relationship between Smartphone addiction and sleep quality in adolescents. This research is quantitative research with a correlation approach using data collection techniques in the form of a Smartphone addiction scale and sleeps quality scale. Research subjects amounted to 75 of the total population of 300 students at High School of Al Falah Ketintang in Surabaya. The sampling technique of this study uses a random sampling technique. For technical data analysis used the non-parametric analysis technique, namely spearman rho analysis. The results showed that the correlation value p = 0.001 <0.05 means that Ha is accepted. The correlation coefficient between two variables is -0.372. This result means that there is a relationship between Smartphone addiction and sleep quality in adolescents. Based on these results it can also be understood that the correlation is negative, thus indicating a reversed relationship, meaning that the higher the Smartphone addiction, the lower the quality of sleep in adolescents.
Who got what from social policy reforms in Mexico? : the redistributive potential of changes in the tax/benefit system between 1994 and 2012

Social policy has been transformed in Mexico during the last two decades. Social insurance programmes on which welfare provision was based throughout the twentieth century have been retrenched and new social assistance programmes have been introduced and expanded. This thesis aims to reveal the redistributive potential of these social policy reforms. The research maps the changes in the welfare policy architecture and estimates their vertical and horizontal redistributive effects. The study identifies the winners and losers of the reform process, the specific changes in the structure of the architecture that benefited different population groups and characterises the welfare model that emerged from the reform process. The research consists on the hypothetical simulation of the effects of changes in the tax/benefit system. The thesis adapts the ‘model families’ method to estimate and compare the effects of taxes and benefits at the household level before and after the reforms. Findings highlight that the productivist/residual logics adopted in the design of the reforms neglects the welfare of families who do not qualify for social assistance, and results in minimal benefit levels insufficient to raise families above poverty lines. The reforms have reproduced the tax/benefit system’s fragmentation and the unequal levels of protection offered by the state, which block the formation of redistributive coalitions. The outcome is a system of low redistributive potential to reduce high levels of poverty and inequality. The thesis represents an original contribution at the empirical level, because it provides a comprehensive assessment of recent reforms in terms of the population segments favoured by them; at the methodological level, since it applies the micro-simulation logic to the study of social policy in the country; and at the theoretical level, because it characterises the welfare model that has emerged from the reform process.
Volatility and Co-Movement: An Analysis of Stock Markets Behaviour of Selected Emerging and Developed Countries During the GFC

In this paper, we analyse historical stock market volatility and co-movement behaviour of three emerging markets and three developed economies from January 2001 to December 2012. We find evidence that the sample of emerging economies exhibits higher stock market volatility during the study period and these volatilities increases during the global financial crisis (GFC). There is also evidence that our sample of the emerging economies exhibit higher level of stock market co-movement behaviour during the study period, for example Indonesia and Malaysia exhibit higher R-square values during 2007-2012. However, we do not find any evidence of a statistically significant correlation coefficient between the volatility measures and the co-movement measures for our sample developed and emerging countries, except for Indonesia. Therefore, it is concluded that both these market models capture different aspects of stock market behaviour.