Miracle-dz/UniFAR-FTUs huggingface dataset:
Modeling the Effects of the Circadian Clock on Cardiac Electrophysiology

An internal circadian clock regulates the electrical activity of cardiac myocytes controlling the expression of potassium channel interacting protein–2 (KChIP2), which is a key regulator of cardiac electrical activity. Here, we examine how the circadian rhythm of KChIP2 expression affects the dynamics of human and murine ventricular action potentials (APs), as well as the intervals in the equivalent electrocardiograms (ECGs) reflecting the duration of depolarization and repolarization phases of the cardiac ventricular APs (QRS and QT intervals), with mathematical modeling. We show how the internal circadian clock can control the shape of APs and, in particular, predict AP, QRS, and QT interval prolongation following KChIP2 downregulation, as well as shortening of AP, QRS, and QT interval duration following KChIP2 upregulation. Based on the circadian expression of KChIP2, we can accurately predict the circadian rhythm in cardiac electrical activity and suggest the transient outward potassium currents as the key current for circadian rhythmicity. Our modeling work predicts a smaller effect of KChIP2 on AP and QT interval dynamics in humans. Taken together, these results support the role of KChIP2 as the key regulator of circadian rhythms in the electrical activity of the heart; we provide computational models that can be used to explore circadian rhythms in cardiac electrophysiology and susceptibility to arrhythmia.
Cooperative Control of Distributed Energy Storage Systems in a Microgrid

Energy storage systems (ESSs) are often proposed to support the frequency control in microgrid systems. Due to the intermittency of the renewable generation and constantly changing load demand, the charging/discharging of various ESSs in an autonomous microgrid needs to be properly coordinated to ensure the supply-demand balance. Recent research has discovered that the charging/discharging efficiency of ESSs has remarkable dependence on the charging/discharging rate and state-of-charge of the ESS. This paper proposes a distributed cooperative control strategy for coordinating the ESSs to maintain the supply-demand balance and minimize the total power loss associated with charging/discharging inefficiency. The effectiveness of the proposed approach is validated by simulation results.
Impacts of Pacific and Indian Ocean coupling on wintertime tropical intraseasonal oscillation: a basin‐coupling CGCM study

This study examines the respective influences of Pacific and Indian Ocean couplings on tropical intraseasonal oscillation (ISO) in boreal winter (November–April). Three basin‐coupling experiments are performed with a coupled atmosphere‐ocean general circulation model (CGCM), in which air‐sea coupling is limited respectively to the Indian Ocean, the Pacific Ocean, and both the oceans. The modelling results show that zonal ISO propagations can be found in the Indo‐Pacific region with or without the ocean coupling; however, the propagation signals are enhanced by the coupling. In this particular model the Pacific Ocean coupling has a stronger influence on the ISO propagation than the Indian Ocean coupling. Without the Pacific coupling, the ISO propagation signal is weakened significantly when it enters the Pacific Ocean sector. Without the Indian Ocean coupling, the simulated ISO intensity is weakened less in the Indain Ocean, and significant zonal propagations of ISO can still be simulated in the sector. The relative importance of the ocean coupling is likely related to the smaller ISO‐related sea surface temperature (SST) anomalies in the Indian Ocean than in the Pacific Ocean. In this particular CGCM, the ocean coupling affects the ISO propagation mainly through a wind‐evaporation‐SST feedback rather than a cloud‐radiation‐SST feedback, while in observations both processes are equally important. To further confirm the importance of the ocean coupling, forced atmospheric GCM experiments are performed with SSTs prescribed from the climatologies produced in the basin‐coupling experiments. It is found that the eastward propagating feature seen in the CGCM experiments is weakened and dominated by the strong standing feature in the forced AGCM runs. The difference demonstrates the contribution of the ocean coupling to the ISO propagation, and also confirm that biases in the mean SST and low‐level wind caused by the ocean coupling are responsible for the spurious standing ISO oscillation feature in the central Pacific and Indian Oceans. Copyright © 2009 Royal Meteorological Society
IDENTIFICATION OF SUSCEPTIBLE AND TOLERANT GRAM (CICER ARIETINUM L.) GENOTYPES AGAINST GRAM POD BORER (HELICOVERPA ARMIGERA) (HUBNER)

The use of crop varieties resistant or tolerant to insect pests stress is an imperative approach in non-chemical crop protection. In the presented studies, 16 genotypes of gram (Cicer arietinum L. were utilized for field assessment against gram pod borer (Helicoverpa armigera Hubner) (Lepidoptera: Noctuidae) to evaluate their genotypic differences. Results on identification of susceptible and tolerant genotypes observed significant differences among the genotypes tested for same traits under consideration. Based on the data for larval population, percentage pod damage and yield components, genotypes CM 2100/96 and CM-4068/97 were relatively resistant, while, lines No. 96051 and PBC-2000 susceptible against preference of the H. armigera in contrast to other genotypes. Oviposition activities of moth were also monitored to trace the eggs of pest on gram, weeds and crops growing around the experimental field. It is suggested that gram genotypes located as sources of tolerance for H. armigera deserve due attention for resistance breeding strategies, if gram has to remain a viable crop.
Psychological constraints on form-bearing dimensions in music

In raising the question of form-bearing dimensions in music, we are trying to understand the possibilities and limits of the apprehension of musical form in terms of the psychological mechanisms that operate on a received acoustic structure. To approach this understanding theoretically and experimentally, we need to define the notion of form-bearing dimension and to develop some ideas of the interactions that take place between perceptual processes and memory structures as form is accumulated in the mind of a listener. Three areas of psychological concern are discussed: perceptual grouping processes, abstract musical knowledge structures and event structure processing. For each area, the constraints on different musical dimensions such as pitch, duration, dynamics and timbre are examined in light of their potential to carry musical form.
Potassium Supplementation Versus Bendrofluazide in Mildly to Moderately Hypertensive Kenyans

Eighty-four consecutive black patients who had confirmed but untreated hypertension participated in a double-blind randomized clinical trial involving potassium supplement (64 mmol/day) versus hendrotluazide (10 mg/day). Diastolic blood pressure (DBP) of the 42 patients receiving potassium supplementation (group A) decreased from a mean (± SD) of 108 ± 3 to 88 ± 4 mm Hg (p < 0.001: paired t test) after 28 weeks of medication. DBP of the 42 patients receiving hendrotluazide (group B) decreased from a mean of 108 ± 2 to 84 ± 4 mm Hg (p < 0.001: paired t test). There was no statistically significant difference between the magnitude of decrease in DBP in group A and B patients (unpaired t test). No clinical, biochemical, or ECG abnormalities occurred in group A patients. Eight group B patients showed hyperuricemia: 4 patients in the same group had hyperglycemia and 3 other patients had hypokalemia. The results support the notion that potassium supplementation may he an effective therapeutic approach to mildly hypertensive blacks.
Lack of intra‐patient strain variability during infection with Kaposi's sarcoma‐associated herpesvirus

Letters and correspondence submitted for possible publication must be identified as such. Text length must not exceed 500 words and five bibliographic references. A single concise figure or table may be included if it is essential to support the communication. Letters not typed double-spaced will not be considered for publication. Letters not meeting these specifications will not be returned to authors. Letters to the Editor are utilized to communicate a single novel observation or finding. Correspondence is to be used to supplement or constructively comment on the contents of a publication in the journal and cannot exceed the restrictions for Letters to the Editor. The Editor reserves the right to shorten text, delete objectional comments, and make other changes to comply with the style of the journal. Permission for publication must be appended as a postscript. Submissions must be sent to Paul Chervenick, M.D., Editor of Brief Reports/Letters to Editors, American Journal of Hematology, H. Lee Moffitt Cancer Center, University of South Florida, 12902 Magnolia Drive, Tampa, FL 33612 to permit rapid consideration for publication.
In Vivo Evaluation of a Mechanically Oscillating Dual-Mode Applicator for Ultrasound Imaging and Thermal Ablation

Unresectable liver tumors are often treated with interstitial probes that modify tissue temperature, and efficacious treatment relies on image guidance for tissue targeting and assessment. Here, we report the in vivo evaluation of an interstitial applicator with a mechanically oscillating five-element dual-mode transducer. After thoroughly characterizing the transducer, tissue response to high-intensity ultrasound was numerically calculated to select parameters for experimentation in vivo. Using perfused porcine liver, B-mode sector images were formed before and after a 120-s therapy period, and M-mode imaging monitored the therapy axis during therapy. The time-averaged transducer surface intensity was 21 or 27 W/cm2. Electroacoustic conversion efficiency was maximally 72 ± 3% and impulse response length was 295 ± 1.0 ns at -6 dB. The depth of thermal damage measured by gross histology ranged from 10 to 25 mm for 13 insertion sites. For six sites, M-mode data exhibited a reduction in gray-scale intensity that was interpreted as the temporal variation of coagulation necrosis. Contrast ratio analysis indicated that the gray-scale intensity dropped by 7.8 ±3.3 dB, and estimated the final lesion depth to an accuracy of 2.3 ± 2.4 mm. This paper verified that the applicator could induce coagulation necrosis in perfused liver and demonstrated the feasibility of real-time monitoring.
The Efficacy of Handheld Resistive Exercise Device (HRED) Training on Wellness Outcome in Older Adults

The primary purpose of this study was to examine the efficacy of Handheld Resistive Exercise Device (HRED) training on wellness outcomes in older adults. A secondary purpose was to assess the utilization of an HRED in older adult fitness program. A group of healthy, active older adults (N=28, 76.6 ± 6.7 years old) volunteered to complete a 10-week HRED training program. Pre- and post-intervention changes were evaluated for muscular strength, static balance, mobility, fall-efficacy, and self-efficacy for activities of daily living. Significant improvement was seen in muscular strength (grip strength, p < 0.01), mobility (TUG time, p <0.01), and self-efficacy for jogging (p = 0.036) and push-ups (p = 0.045). Most of participants (92.9%) indicated that they would like to continue exercising with the HRED. A 10-week HRED exercise program produced some improvement on wellness outcomes in older adults and the HRED is an acceptable fitness device for this population.
Phosphorylation of MCM3 on Ser-112 regulates its incorporation into the MCM2–7 complex

During late M and early G1, MCM2–7 assembles and is loaded onto chromatin in the final step of prereplicative complex (pre-RC) formation. However, the regulation of MCM assembly remains poorly understood. Cyclin-dependent kinase (CDK)-dependent phosphorylation contributes to DNA replication by initially activating pre-RCs and subsequently inhibiting refiring of origins during S and M phases, thus limiting DNA replication to a single round. Although the precise roles of specific MCM phosphorylation events are poorly characterized, we now demonstrate that CDK1 phosphorylates MCM3 at Ser-112, Ser-611, and Thr-719. In vivo, CDK1-dependent phosphorylation of Ser-112 triggers the assembly of MCM3 with the remaining MCM subunits and subsequent chromatin loading of MCMs. Strikingly, loss of MCM3 triggers the destabilization of other MCM proteins, suggesting that phosphorylation-dependent assembly is essential for stable accumulation of MCM proteins. These data reveal that CDK-dependent MCM3 phosphorylation contributes to the regulated formation of the MCM2–7 complex.
High‐dose Ara‐C and beam with autograft rescue in R‐CHOP responsive mantle cell lymphoma patients

Mantle cell lymphoma (MCL) has a dismal outcome when treated with conventional chemotherapy. This single arm phase 2 study evaluated intensive consolidation treatment of patients with newly diagnosed MCL up to the age of 65 years, responsive to R‐CHOP (rituximab, cyclophosphamide, oncovin, adriamycin, prednisolone). Endpoints for evaluation were toxicity, failure‐free survival (FFS) and overall survival (OS). Eighty‐seven patients were treated with three cycles of R–CHOP. Sixty‐six patients responded to R‐CHOP with at least a partial response, 62 continued protocol treatment with high‐dose cytarabine (Ara‐C; 2000 mg/m2, bid. over 4 d) and 61 patients received rituximab and stem cell harvest, followed by BEAM (carmustine, etoposide, Ara‐C, melphalan) and autologous stem cell rescue. Non‐haematological toxicity, grades III and IV, was seen in 8% of the patients after R‐CHOP, in 22% after high‐dose Ara‐C and in 55% after BEAM. The overall response rate was 70% (complete response rate 64%, partial response rate 6%), FFS and OS at 4 years were 36 ± 7% and 66 ± 6%, respectively. The FFS and OS at 4 years from the evaluation after BEAM in the 61 R‐CHOP responsive patients was 46 ± 9% and 79 ± 7%, respectively. In conclusion, high‐dose Ara‐C and BEAM with stem cell rescue in newly diagnosed MCL patients responsive to R‐CHOP is a manageable treatment with respect to toxicity. This regimen leads to long‐term, but probably not durable, remissions.
Terbinafine in the treatment of non‐immunocompromised compassionate cases of bronchopulmonary aspergillosis

Summary. Conventional treatments of bronchopulmonary aspergillosis are often ineffective and result in associated side‐effects. Terbinafine (a new allylamine derivative), although as active against Aspergillus in vitro as amphotericin B and itraconazole, is less effective in rodent models because of a rapid hepatic first‐pass effect. As terbinafine is metabolized differently in humans, the aim of this work was to evaluate this drug, for the first time, in the treatment of seven immunocompetent patients with lower respiratory tract mycotic infections unresponsive to the usual antimycotic drugs. Diagnosis was based on identification of fungal isolates, worsening of respiratory function tests, chest radiographs and computerized tomographic (CT) scan changes, positive skin test, aspergillin precipitins and clinical history. Terbinafine was administered at doses ranging from 5 to 15 mg kg‐1 day‐1 depending on the clinical severity of the disease, and was given for 90–270 days depending on clinical progress and compliance. In three patients A. fumigatus was suppressed with resolution of signs and symptoms; four patients showed transitory A. fumigatus suppression with marked clinical and radiological improvement. During relapses no resistance to terbinafine was observed. No significant side‐effects were detected. Terbinafine appeared to be as effective as amphotericin B and itraconazole in the treatment of bronchopulmonary aspergillosis in non‐immunocompromised patients. These preliminary results suggest that controlled studies are warranted.
EFFECT OF DIFFERENT SALT CONCENTRATIONS ON CHEMICAL COMPOSITION OF THE FISH hydrocynus spp.

This piece of work was directed towards the study of the proximate chemical composition to compare the effect of the different salt concentrations on the nutritive value of fish. In both fresh fish and fassiek (salted fish). Proximate analysis targeted the determination of moisture%, protein%, ash%, fat and pH. Contents were determined by wet samples. The proximate composition of the fresh samples was 70.9%, 24.2%, 3.8%, 1.2% and 7.05 for moisture, protein, fat, ash and pH respectively. The proximate composition of fassiekh (moisture, protein, fat, ash and pH) for 15% salt was 60.3%, 21.7%, 3.4%, 10.5% and 6.6 respectively. And for 20% salt was 56.7%, 19.2%, 3.2%, 12.9% and 6.0 respectively. And for 25% salt was 52.2%, 17.6%, 1.9%, 14.1%, and 5.8 respectively. As for the proximate composition of fassiekh it is clearly observed that all the studied parameters are significantly different in fresh treated samples. Variations appeared to be due to the interaction of the salting treatment.
A descriptive study of registered nurses' experiences with web-based learning.

AIMS To describe the experiences of registered nurses (RNs) who enrolled in a web-based course from either their home or the workplace. RATIONALE In order to maintain competency in rapidly changing health care systems, and meet the challenge of overcoming traditional barriers to continuing education, RNs need access to innovative educational delivery methods. As yet, little is known about the web-based learners' experience, particularly when courses are accessed from the nursing practice setting. METHODS The article focuses on the results from questionnaires conducted with 57 RNs enrolled in a web-based, postdiploma course. These findings emanate from a larger study using survey method and focus group interviews. Nurses' experiences were measured using the Online Learner Support Instrument which was developed and tested for use in the study. RESULTS Most nurses found the course highly satisfactory. Not all experiences were positive however, and a number of challenges were faced. Access to the course from home was reported as very satisfactory for the majority, while work users encountered a number of serious barriers such as insufficient time and limited computer access. The RNs made significant gains in their learning with e-mail, Internet, keyboarding and word processing skills during the 16-week course. Lack of computer skills, erroneous perceptions of course workload and inadequate preparation for web learning were largely responsible for the majority of withdrawals. CONCLUSION Web-based learning can be an effective mode of delivery for nursing education. Advance preparation by educational institutions, employers and prospective students is essential. Teachers, peers, technology, course design and the learning environment are key variables that influence the learners' experience and success.
Electroconvulsive therapy for refractory status epilepticus in a child: A case report

1. McGrath A, Reid N, Boore J. Occupational stress in nursing. Int J Nurs Stud 2003;40:555-65. 2. Hughes RG, Rogers AE. Are you tired? Am J Nurs 2004;104:36-8. 3. Johnson CJ, Croghan E, Crawford J. The problem and management of sickness absence in the NHS: Considerations for nurse managers. J Nurs Manag 2003;11:336-42. 4. McVicar A. Workplace stress in nursing: A literature review. J Adv Nurs 2003;44:633-42. 5. Buysse DJ, Reynolds CF 3rd, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: A new instrument for psychiatric practice and research. Psychiatry Res 1989;28: 193-213. 6. Johns MW. A new method for measuring daytime sleepiness: The Epworth Sleepiness Scale. Sleep 1991;14:540-5. 7. Short MA, Gradisar M, Lack LC, Wright HR. The impact of sleep on adolescent depressed mood, alertness and academic performance. J Adolesc 2013;36:1025-33. 8. Vanderlind WM, Beevers CG, Sherman SM, Trujillo LT, McGeary JE, Matthews MD, et al. Sleep and sadness: Exploring the relation among sleep, cognitive control, and depressive symptoms in young adults. Sleep Med 2014;15:144-9. 9. Sivertsen B, Lallukka T, Salo P, Pallesen S, Hysing M, Krokstad S, et al. Insomnia as a risk factor for ill health: Results from the large population-based prospective HUNT Study in Norway. J Sleep Res 2014;23:124-32. 10. Baldwin DC Jr, Daugherty SR. Sleep deprivation and fatigue in residency training: Results of a national survey of firstand second-year residents. Sleep 2004;27:217-23. 11. Landrigan CP, Rothschild JM, Cronin JW, Kaushal R, Burdick E, Katz JT, et al. Effect of reducing interns’ work hours on serious medical errors in intensive care units. N Engl J Med 2004;351:1838-48.
The Effects of Diet, Ad Libitum Overfeeding, and Moderate Dietary Restriction on the Rodent Bioassay: The Uncontrolled Variable in Safety Assessment

Ad libitum (AL) overfeeding is the most significant, uncontrolled variable affecting the outcome of the current rodent bioassay. There is a highly significant correlation between AL food consumption, the resultant obesity and body weight, and low 2-yr survival in rodents. AL feeding of diets with lowered protein, metabolizable energy (ME), and increased fiber does not improve survival. Only dietary restriction (DR) of all diets tested significantly improves survival and delays the onset of spontaneous degenerative disease (i.e., nephropathy and cardiomyopathy) and diet-related tumors. Moderate DR results in an incidence of spontaneous tumors similar to AL-fed rats, but the tumors are found incidentally and do not cause early mortality. There is a decreased age-adjusted incidence of pituitary and mammary gland tumors in moderate DR-fed rats, but tumor growth time is similar between AL and DR rats with only a delay in tumor onset time seen in DR-fed groups. Moderate DR does not significantly alter drug-metabolizing enzyme activities nor the toxicologic response to 5 pharmaceuticals tested at maximum tolerated doses (MTDs). However, moderate DR-fed rats did require much higher doses of 4 additional pharmaceutical compounds before classical MTDs were produced. Toxicokinetic studies of 2 of these compounds demonstrated equal or higher steady-state systemic exposures to parent drug and metabolites in moderate DR-fed rats. Markers of oxidative stress (lipid peroxidation, protein oxidation) are decreased and cytoprotective anti-oxidant markers are preserved in moderate DR-fed rats. But moderate DR does not delay reproductive senescence in female rats. Only marked DR delays reproductive senescence compared to AL and moderate DR-fed female rats. These and other data indicate that moderate DR is the most appropriate method of dietary control for the rodent bioassay when used to assess pharmaceuticals for human safety and compounds for risk assessment.