Miracle-dz/UniFAR-FTUs huggingface dataset:
How the quark self-energy affects the color-superconducting gap

We consider color superconductivity with two flavors of massless quarks which form Cooper pairs with total spin zero. We solve the gap equation for the color-superconducting gap parameter to subleading order in the QCD coupling constant g at zero temperature. At this order in g, there is also a previously neglected contribution from the real part of the quark self-energy to the gap equation. Including this contribution leads to a reduction of the color-superconducting gap parameter ${\ensuremath{\varphi}}_{0}$ by a factor ${b}_{0}^{\ensuremath{'}}=\mathrm{exp}[\ensuremath{-}({\ensuremath{\pi}}^{2}+4)/8]\ensuremath{\simeq}0.177. $ On the other hand, the BCS relation ${T}_{c}\ensuremath{\simeq}0.57{\ensuremath{\varphi}}_{0}$ between ${\ensuremath{\varphi}}_{0}$ and the transition temperature ${T}_{c}$ is shown to remain valid after taking into account corrections from the quark self-energy. The resulting value for ${T}_{c}$ confirms a result obtained previously with a different method.
Identification and evaluation of potential anti-cancer drugs on human neuroendocrine tumor cell lines.

UNLABELLED The aim of this study was to investigate drug sensitivity in neuroendocrine tumor cell lines. MATERIALS AND METHODS In vitro drug sensitivity screening was performed using the fluorometric microculture cytotoxicity assay in one human pancreatic carcinoid and two human bronchial carcinoid cell lines. In addition, a normal human retinal pigment epithelial cell line was used for comparison. A total of 18 drugs with different mechanisms of action were tested. RESULTS The most active agents were brefeldin A, emetine, bortezomib and idarubicin, having IC5o values <1 microM in all four cell lines. In addition, the three tumor cell lines showed sensitivity for sanguinarine, Bayll-7085, mitoxantrone, doxorubicin, beta-lapachone, NSC 95397 and CGP-74514A. CONCLUSION The cell lines were sensitive for several drugs acting in different ways, covering a broad spectrum of mechanisms of action. Some of these compounds may possibly be used in clinical trials and show therapeutic effect in patients with neuroendocrine tumors.
Long-Term Outcomes Following Sirolimus Conversion after Renal Transplantation

Long-term outcomes following renal transplantation remain limited due to chronic progressive injury partly as a result of calcineurin inhibitor (CNI) toxicity. Thus, patients have been converted to non-CNI immunosuppressives despite the lack of evidence of long-term benefits from CNI free therapy. We now report our 10-year experience converting patients with well functioning transplants from CNI to sirolimus. We retrospectively analyzed outcomes of patients receiving continuous CNI based therapy (CNI, n = 309) or who were switched to sirolimus within the first year of post-transplantation (CONV, n = 54). The groups were similar for most recipient, graft and donor characteristics, however, diabetes was more common in the CNI group and statin use was more frequent in the CONV group. The average time to conversion was 7.2 months and the creatinine level at the time of switching was 1.4 mg/dl. Ten year graft and patient survival rates were equivalent in both groups. There were no differences in the causes of death or graft loss in both groups. Renal function was available for 5 years posttransplant and was no different between groups. Thus, there is no evidence that routinely switching patients with well functioning renal allografts to sirolimus from CNI based immunosuppression provides long-term benefit.
RETICULAR PSEUDODRUSEN ON INFRARED IMAGING ARE TOPOGRAPHICALLY DISTINCT FROM SUBRETINAL DRUSENOID DEPOSITS ON EN FACE OPTICAL COHERENCE TOMOGRAPHY

Purpose: To evaluate the quantitative and topographic relationship between reticular pseudodrusen (RPD) on infrared reflectance (IR) and subretinal drusenoid deposits (SDD) on en face volumetric spectral domain optical coherence tomography. Methods: Reticular pseudodrusen were marked on IR images by a masked observer. Subretinal drusenoid deposits were visualized on en face sections of spectral domain optical coherence tomography below the external limiting membrane and identified by a semiautomated technique. Control RPD lesions were generated in a random distribution for each IR image. Binary maps of control and experimental RPD and SDD were merged and analyzed in terms of topographic localization and quantitative drusen load comparison. Results: A total of 54 eyes of 41 patients diagnosed with RPD were included in this study. The average number of RPD lesions on IR images was 320 ± 44.62 compared with 127 ± 26.02 SDD lesions on en face (P < 0.001). The majority of RPD lesions did not overlap with SDD lesions and were located >30 &mgr;m away (92%). The percentage of total SDD lesions overlapping RPD was 2.91 ± 0.87% compared with 1.73 ± 0.68% overlapping control RPD lesions (P < 0.05). The percentage of total SDD lesions between 1 and 3 pixels of the nearest RPD lesion was 5.08 ± 1.40% compared with 3.33 ± 1.07% between 1 and 3 pixels of the nearest control RPD lesion (P < 0.05). Conclusion: This study identified significantly more RPD lesions on IR compared with SDD lesions on en face spectral domain optical coherence tomography and found that a large majority of SDD (>90% of lesions) were >30 &mgr;m away from the nearest RPD. Together, our findings indicate that RPD and SDD are two entities that are only occasionally topographically associated, suggesting that at some stage in their development, they may be pathologically related.
Variability Effects on Retention of a Motor Skill in Elementary School Children

Variability effects on learning, retention, and transfer of motor skills have been a main issue for scientists involved in laboratory and field research. Variable practice is intended as parameter variations of a generalized motor program as well as rehearsal of different motor programs. Although the benefits deriving from variable practice on motor skill retention appear quite robust in laboratory settings, field investigations have produced mixed results. Hence, the aim of this study was to examine the effects of different variable schedules on the retention of a complex motor skill in a physical education setting. 61 elementary school children were assigned to Blocked/Nonvariable, Blocked/Variable, Serial/Nonvariable, or Serial/Variable schedules, and practiced two tasks (throwing and hurdle running) and a complex skill (jumping) across 14 lessons. Improved performance in the complex skill was found after practice, with the Serial/Nonvariable group outperforming all other groups. Therefore, the rehearsal of different motor programs was beneficial for jumping skill retention, whereas parameter variation was not.
Living Arrangements and Conditions of Older Persons in Namibia

In Africa, ageing is a phenomenon that is just beginning to reveal its shape. Most governments, including the Namibian government, recognize the fact that the number of older persons is on the increase, however, discussing it is still a distant phenomenon and family matter. This paper examines the living arrangements of older adults in Namibia, identifying the existing structure of living arrangements and the nature of family relationships of older people, as well as provides some basic descriptive information on the housing conditions in which older persons live and how they are associated with their socioeconomic and demographic factors. The analysis is based on 1991, 2001 and 2011 Namibia Population and Housing Censuses. The study concluded that living arrangements is constantly changing from extended family pattern to western nuclear family, mainly due to urbanization and decreased fertility rate. Housing conditions had notably improved in rural areas while in urban areas the conditions are affected by the mushrooming of informal settlements. There is need to encourage or conduct focused research on ageing to help coin policies based on evidence and make communities sensitive towards ageing. The study further recommends Government to encourage old people to form organizations that would in turn focus on sensitizing and help championing issues of ageing and aged persons.
Monoclonal antibodies specific for simian virus 40 tumor antigens

Thirty hybridomas that secrete immunoglobulins against the simian virus 40 tumor antigens were isolated and cloned. Of these, 28 produced antibodies which bound to simian virus 40 large-T, and 2 produced antibodies which bound to the host 53,000-dalton protein. As in previous work, large-T antigen was found to have at least one determinant that it shared with small-t antigen and to have a minimum of six unique determinants. Several of the monoclonal antibodies from the L series hybridomas recognized determinants that were present on a subset of the large-T antigen from simian virus 40-transformed mouse cells. These monoclonal antibodies should be useful in studies of the structure and function of the simian virus 40 tumor antigens.
The neurological, neuroimaging and neuropsychological effects of playing professional football: Results of the UK five-year follow-up study

Abstract Background: Whilst the scientific understanding of mild traumatic brain injury sequelae has advanced, the consequences of neurological insults sustained during football play in the form of multiple concussions and heading remains unclear. Method: To the authors’ knowledge, this is the first longitudinal prospective study to follow-up a group of footballers and controls over time. Thirty-two elite young professional footballers were recruited and 24 were identified at follow-up. Thirty-three controls were recruited and 17 identified at follow-up. Medical examination, MRI (brain) imaging and detailed neuropsychological data were collected on the footballers at baseline and 5-year follow-up. Medical examination and detailed neuropsychological data were collected on the controls at baseline and 5-year follow-up. Results: All participants had normal neurological examination at both time points. At baseline, 37% of the footballers had sustained minor neurological insults. Between baseline and 5 years, 66% of the footballers had sustained minor neurological insults. No MRI (brain) abnormalities were identified among the footballers at either time point. Regarding the neuropsychology, there was a 6-point IQ difference between footballers and controls, with the footballers being low. Test–re-test analysis on a range of carefully selected neurocognitive tests revealed a picture of good stability in cognitive functioning over this 5-year period. Conclusions: These longitudinal prospective data indicate no significant neurological, structural brain imaging or neuropsychological change among a sample of young elite professional footballers over the first 5 years of their professional career.
Studies on the Mechanisms of Immunity in Human Schistosomiasis

Studies on immunity in schistosomiasis, as in other parasitic infections, have followed two distinct directions: first, the use of experimental animal models, in either natural or unnatural host-parasite combinations; and, secondly, the use of assay systems for studying immune effector mechanisms m vilro. Each of these two approaches, which are not mutually exclusive, has its own advantages and disadvantages. The experimental animal models may permit the identification of effector mechanisms that are demonstrably involved in mediating immunity In vivo. However, there appears to be a wide species variation in host response to schistosome infection (reviewed by Smithers & Terry 1976, Phillips & Colley 1978) and there is no evidence that any experimental animal provides an accurate reflection of the situation in man. In contrast, studies in vilro can provide no direct evidence for the role of various effector mechanisms in vivo. However, they do allow a more precise identification and detailed analysis of each mechanism than would be po.ssibie in vivo: and, more importantly, they can be carried out with human materials, and therefore offer an approach to the study of human immunity.
Chapter Six. Aristotle And Scholasticism

In 1969 Brian Armstrong expressly attributed to Peter Martyr Vermigli a 'scholastic methodology' and a special 'affinity with Aristotle', quoting as evidence for his opinion a statement of B.B. Warfield, according to whom 'the scholastic theologian among the early Reformers was Peter Martyr'. Perhaps inspired by Armstrong's vague allusions, further research in the following decades has contributed to showing the extent to which the Aristotelian and scholastic tradition influenced Vermigli, and what consequences this had for the structure and contents of his theology. In order to sketch the contours of Vermigli's 'Aristotelianism' and 'scholasticism', this chapter relies on the achievements of past research as well as on Vermigli's one philosophical work, namely his Commentary on the Nicomachean Ethics. The chapter also sketches the way in which Reformed theologians looked at Aristotelianism and scholasticism around the middle of the sixteenth century. Keywords: Aristotle; Peter Martyr Vermigli; Scholasticism
Perineal Approaches to Rectal Prolapse

Abstract Full-thickness rectal prolapse is a painful and debilitating condition that often responds well to surgical intervention. The best method of surgical repair is a matter of debate. Historically, perineal approaches have been thought to have inferior outcomes and were therefore reserved for elderly and unfit patients. Despite recent data calling that into question, perineal approaches are still commonly performed and have their role. We present risks and benefits along with a description of perineal approaches for surgical treatment of rectal prolapse.
Fungi associated with Esca disease of grapevine in Germany

Esca disease of grapevine is gaining increasing importance in Central European wine-growing countries. Several fungi, all of which are wood-inhabiting, were found to be associated with the disease. The taxa thought to act as main causal agents are the basidiomycete, Fomitiporia mediterranea , and, less frequently, the deuteromycetes, Phaeomoniella chlamydospora and Phaeoacremonium aleophilum . In addition, the species Eutypa lata, Phomopsis viticola, Botryosphaeria obtusa , and Cylindrocarpon destructans were isolated from Esca-affected vines. These species have been described in a standardized style and information is provided on taxonomy, cultured mycelium, microscopical characters, nuclear behaviour, as well as restriction and sequence data of ribosomal DNA.
The role of early life nutrition in programming of reproductive function

Accumulating evidence suggest that the concept of programming can also be applied to reproductive development and function, representing an ever expanding research area. Recently issues such as peri- or even preconceptional nutrition, transgenerational effects and underlying mechanisms have received considerable attention. The present chapter presents the existed evidence and reviews the available data from numerous animal and human studies on the effects of early life nutritional environment on adult reproductive function. Specific outcomes depend on the severity, duration and stage of development when nutritional perturbations are imposed, while sex-specific effects are also manifested. Apart from undernutrition, effects of relative overnutrition as well as the complex interactions between pre- and postnatal nutrition is of high importance, especially in the context of our days obesity epidemic. Mechanisms underlying reproductive programming are yet unclear, but may include a role for epigenetic modifications. Epigenetic modulation of critical genes involved in the control of reproductive function and potential intergenerational effects represent an exciting area of interdisciplinary research toward the development of new nutritional approaches during pre- and postnatal periods to ensure reproductive health in later life.
Effects of different levels of selenium on growth performance and immunocompetence of broilers under heat stress

An experiment was undertaken to evaluate the effect of dietary selenium (Se) levels on growth performance and immune competence of broilers under heat stress. Birds were raised in either a thermoneutral (TN, 23.9°C constant) or heat stress conditions (HS, 23.9°C to 38°C cycling) and were fed a corn-soybean meal basal diet supplemented with Se at 0, 0.2 and 0.4 mg/kg. A total of 240 one-day-old male broiler chicks were randomly assigned to six groups; each group had four replicates of 10 birds. Body weight and feed intake were not influenced by dietary Se, while feed conversion was significantly improved by a Se-supplementation of 0.2 mg/kg. HS significantly reduced body weight, feed intake and feed conversion. Numbers of abdominal exudate cells (AEC), percentage of macrophages in AEC, phagocytic macrophages, internalized opsonised and unopsonised sheep red blood cells (SRBC) were significantly increased by dietary Se. Both primary and secondary antibody responses were characterised by increasing titres of antibody to SRBC by dietary Se when birds were exposed to HS (p < 0.05). Lymphoid organ weights, antibody responses, incidence of macrophages in AEC, and phagocytic ability of macrophages were also significantly reduced under HS. These results indicated that HS severely reduced growth performance and immunocompetence of broilers, whereas the immune response of broilers improved by dietary Se supplementation under HS.
Clinical features of hereditary progressive arthro-ophthalmopathy (Stickler syndrome): A survey

Purpose: To define variations in the clinical manifestations of Stickler syndrome.Methods: A questionnaire was sent to 612 persons.Results: Of the 316 usable replies, 95% of persons had eye problems (retinal detachment occurred in 60% of patients, myopia in 90%, and blindness in 4%); 84% had problems with facial structures such as a flat face, small mandible, or cleft palate; 70%, hearing loss; and 90%, joint problems, primarily early joint pain from degenerative joint disease. Treatment included cryotherapy and laser therapy for retinal detachment, repair of cleft palate, use of hearing and mobility aids, and joint replacements.Conclusions: There are wide variations of symptoms and signs among affected persons, even within the same family. There are delays in diagnosis, lack of understanding among family members, denial about the risk of serious eye problems, and joint disease.
Blocking Fcα Receptor I on Granulocytes Prevents Tissue Damage Induced by IgA Autoantibodies

IgA represents the most prominent Ab class at mucosal surfaces and the second most prevalent Ab in human blood after IgG. We recently demonstrated that cross-linking of the granulocyte IgA FcR (FcαRI) by IgA induces a chemotactic-driven positive-feedback migration loop, hereby amplifying recruitment of granulocytes to IgA deposits. Therefore, we postulated that aberrant IgA–Ag complexes, which can be found in tissues in IgA-mediated diseases, are responsible for tissue damage by inducing continuous granulocyte migration and activation. Using an IgA-dependent skin-blistering disease as a model system, we demonstrated colocalization of FcαRI-positive granulocyte infiltrates with IgA in cryosections of lesional skin of patients suffering from this disease. Furthermore, we showed granulocyte migration to IgA deposits injected in human skin explants and in murine skin of FcαRI transgenic mice in vivo. Importantly, ex vivo migration and tissue damage were inhibited by blocking FcαRI, indicating that these events are dependent on the interaction of IgA autoantibodies with FcαRI. Thus, interrupting the granulocyte migration loop by blocking FcαRI reduces tissue damage in diseases with aberrant IgA–immune complexes. As such, our results may lead to development of new therapies for IgA-mediated chronic inflammatory diseases, hereby decreasing severe morbidity and improving quality of life for these patients.
3 Diabetic Retinopathy

Elevated glycemia induces a series of bichemical and cellular abnormalities which may cause vascular alterations found in diabetic retinopathy (4,5,6). Mechanisms induced by hyperglycemia which can cause endothelial cells dysfunction include increase of polyol pathway flux, accelerated and non-enzimatic formation of advanced glycation end-products (AGES), increase in diacylglycerol formation (with consequent activation of protein kinase C – PKC), increase of hexosamine pathway flux and a disturbed oxi-reduction status (4,5,6,7). All these mechanisms may contribute to the known phisiological characteristics of diabetic complications through increase of cytokines and growing factors regulation, and through formation of oxygen and nitrogen derived free radicals (8).
Unramified Hilbert modular forms, with examples relating to elliptic curves

We give a method to explicitly determine the space of unramified Hilbert cusp forms of weight two, together with the action of Hecke, over a totally real number field of even degree and narrow class number one. In particular, one can determine the eigenforms in this space and compute their Hecke eigenvalues to any reasonable degree. As an application we compute this space of cusp forms for Q(root 509), and determine each eigenform in this space which has rational Hecke eigenvalues. We find that not all of these forms arise via base change from classical forms. To each such eigenform f we attach an elliptic curve with good reduction everywhere whose L-function agrees with that of f at every place.
A neural network model for the separation of atmospheric effects on attenuation: Application to frequency scaling

Attenuation due to the propagation of radio waves through the Earth's atmosphere plays a major role in satellite link attenuation at frequencies beyond 20 GHz. This paper presents the development of an artificial neural network (ANN) to separate out the respective roles played by the three types of contributor, namely, gases (oxygen and water vapor), clouds, and rain, to the overall attenuation of radio waves. Whereas the inputs to the ANN are the total attenuation measured at either one, two, or three frequencies, the ANN outputs provide the three atmospheric attenuation components at a single frequency. Several neural networks were trained by using a simulated statistically significant data set, derived from absorption and diffusion models applied to atmospheric profiles. Good overall performance was observed, and a particularly good fit was achieved in the case where attenuation inputs were provided at two frequencies. From the estimated values of atmospheric attenuation for the three contributors, corresponding frequency scaling models were applied on each to estimate the three contributions at a new frequency. Total atmospheric attenuation at this new frequency can then be estimated. The method works using measured data at either one, two, or three frequencies and allows the total attenuation to be predicted at any other frequency in the range 20–50 GHz. Validation was successfully performed on real data.
Aplicações do exercício intermitente de alta intensidade na síndrome metabólica

Esta revisao de literatura apresenta os efeitos do exercicio fisico intermitente de alta intensidade (HIIT) em variaveis relacionadas a Sindrome Metabolica (SM). Apos contextualizacao dos criterios de diagnostico, explicitam-se resultados de intervencoes para a SM, bem como as possibilidades de se obter beneficios com o HIIT. Foram recuperados 11 artigos que avaliaram efeitos agudos e 16 que mensuraram efeitos cronicos do exercicio. Apontam-se melhoras na composicao corporal (incluindo gordura visceral), em variaveis cardiovasculares (destaque para a potencia aerobia maxima) e em componentes metabolicos (principalmente relacionados a glicemia). Quando se compararam diferentes tipos de treinamento, intermitente e continuo, observou-se indicacoes favoraveis ao HIIT para os diversos componentes da SM. Em conclusao, a partir deste estudo, observa-se que o HIIT pode ser relevante para a prevencao e tratamento da SM.