Miracle-dz/UniFAR-FTUs huggingface dataset:
Australian immigrantsâ labour market success: Does occupation matter?

This paper utilises the occupational attainment approach to investigate immigrant labour market assimilation, complementing other assimilation approaches such as employability, earnings, skills-match and job satisfaction. While immigrants from English speaking backgrounds attain occupations similar to that of the native-born, this is not true for those from non-English speaking backgrounds. Worryingly for the latter, no ‘catch-up’ over time is evident even when disaggregated to reflect different cultures and backgrounds. Nor is there much evidence that younger arrivals can ‘catch-up’, despite being immersed in local mores and institutions while undertaking schooling in Australia. Newer cohorts of immigrants (those who arrived between 2000 and 2013) are also more prone to suffering an occupational penalty. We recommend policymakers subsidise bridging courses to aid recognition of overseas-obtained qualifications and encourage immigrants to obtain local qualifications that can complement their overseas-obtained work experience. This will increase their ‘Australian-ready’ skill-set and occupational attainment in their new host country.
Methodological Issues in Evaluating Rorschach Validity: A Comment on Burns and Viglion (1996), Weiner (1996), and Ganellen (1996)

The old controversy regarding the Rorschach Inkblot Test has recently revived. The present article suggests that the debate will be most productive if careful attention is paid to methodological issues. Three recent examples illustrate how incorrect conclusions regarding Rorschach validity may occur if methodological issues are not evaluated carefully. The present article examines (a) Burns and Viglione's (1996) conclusion that the Rorschach Human Experience Variable (HEV) is a predictor of interpersonal relatedness among adults; (b) Weiner's (1996) conclusion that the D score and Morbid Responses (MOR) are valid measures of "experienced distress" in Posttraumatic Stress Disorder (PTSD); and (c) Ganellen's (1996a, 1996b) conclusion that the Rorschach Depression Index (DEPI) and the Minnesota Multiphasic Personality Inventory (MMPI) are comparable in their power to identify diagnoses of depression.
Transcriptional up‐regulation of FoxM1 in response to hypoxia is mediated by HIF‐1

The proliferation‐specific Forkhead box M1 (FoxM1) transcription factor is overexpressed in cancer cells and acts as an important regulator of cancer cell growth and survival. Here, we show the molecular mechanisms by which hypoxia regulate FoxM1 expression in cancer cells. When cells were subjected to hypoxia (1% O2), the mRNA and protein levels of FoxM1 had a significant increase in cancer cells (HepG2, MCF‐7, and HeLa). Such increase was due to the direct binding of hypoxia‐inducible factor 1 (HIF‐1) to the HIF‐1 binding sites in the FoxM1 promoter. By deletion and mutation assays, we demonstrated that the HIF1‐1 and HIF1‐3/4 binding sites on the FoxM1 promoter were essential for transcriptional activation of FoxM1 by hypoxia. We also demonstrated that HIF‐1α directly bound to the promoter of FoxM1 and the binding was specific, as revealed by HIF‐1 binding/competition assay and chromatin immunoprecipitation assay. Consequently, the up‐regulation of FoxM1 accelerated the growth of hypoxic cancer cells by decreasing nuclear levels of p21 and increasing expression of cyclin B1 and cyclin D1. These findings provide a new insight into how tumor cells overcome hypoxic stress and survive, and also disclose a new regulatory mechanism of FoxM1 expression in tumor cells. J. Cell. Biochem. 106: 247–256, 2009. © 2008 Wiley‐Liss, Inc.
Individual axon morphology and thalamocortical topography in developing rat somatosensory cortex

The morphology of individual thalamocortical axons in developing rat primary somatosensory cortex was studied using lipophilic tracers. Anterograde labeling with lipophilic dyes demonstrated a topographical organization of thalamocortical projections exiting the thalamus as early as embryonic day (E)16; retrograde labeling studies demonstrated topography of these projections as they reached the cortex as early as E18. At E17, axons course tangentially within the intermediate zone and turn or branch near the deepest layer of cortex (layer VIb), suggesting the presence of guidance cues in this region. Axons appear to grow and branch progressively within layers VIb and VIa during the following days; axons in the intermediate zone may give rise to radially directed branches. Individual axons appear to grow steadily and progressively into the cortex, with the leading front of axons at the transition zone between the cortical plate (CP) and the differentiating cortical layers. At birth (PO), thalamocortical axons extend radially through layers VIa and V and emit branches within these layers; some axons reach the CP. By P1, layer IV has begun to differentiate and axons begin to form a few simple branches in the vicinity of the layer IV cells. Over the ensuing week, axons generate more branches within layer IV, but the tangential extent of individual axon arbors does not exceed the width of a barrel. By P7, individual axons overlap within barrel clusters, and individual axons span the width of a cluster. These observations indicate that thalamic afferents develop by progressive growth of arbors that remain spatially restricted, rather than by overbranching and retracting arbors. © 1996 Wiley‐Liss, Inc.
Agro-clusters and Rural Poverty: A Spatial Perspective for West Java

Neighbouring economies are likely to influence one another. The concentration of farming activities referred to as an ‘agro-cluster’ generates opportunities for income and employment in a given region and its surrounding area. We analyse the link between poverty rates and agro-clusters by accounting for spatial spillovers. To quantify agroclusters, we employ one input-oriented and one output-oriented measure. Our analysis applies six spatial econometric specifications and focuses on 545 subdistricts of West Java, where about 10% of the population live in poverty. We find that the concentration of agricultural employment substantially reduces poverty in a subdistrict as well as in neighbouring subdistricts. We also find that specialisation in crop outputs has positive impacts on poverty reduction and that localisation externalities are fundamental to agriculture's success. These findings imply that policy interventions may be applied in a spatially selective manner because they will generate spatial-spillover effects on poverty reduction in surrounding areas.
Cytomegalovirus Infection of Human Syncytiotrophoblast Cells Strongly Interferes with Expression of Genes Involved in Placental Differentiation and Tissue Integrity

The principle route of acquisition of cytomegalovirus (CMV) for the fetus is believed to be via the placenta. We subjected purified cytotrophoblast cells obtained from full-term placentas to CMV infection and examined placental gene expression using microarray analyses. Cytotrophoblast cells purified from term placentas differentiated in vitro into a multinucleated syncytium that could be productively infected with CMV, with peak virus titers of approximately 104 plaque-forming units (PFU)/mL identified in supernatants at late time points postinoculation. Infected syncytiotrophoblast cells expressed CMV-specific transcripts and proteins, as demonstrated by Northern blot and immunofluorescence assays. Microarray analyses revealed that CMV infection strongly and reproducibly altered trophoblast gene expression, elevating expression of mitotic cell cycle genes, and repressing expression of genes associated with trophoblast differentiation, particularly those associated with formation and stabilization of the extracellular matrix. We conclude that purified, differentiated syncytiotrophoblasts are permissive for CMV replication. Infection of these cells induces significant perturbations in trophoblast transcription. An improved understanding of the molecular events that occur during CMV infection of trophoblasts could provide insights into interventions that might prevent or minimize congenital transmission.
Constructing contexts, (re)defining immigrants: Mental models and social representations in immigration policy defense*

This article examines two different instances of policy defense as a means to show how a socio-cognitive approach to contexts can help develop a dialectical account of the relationship between societal processes and our communicative practices. Based on such analysis, I argue that comparative analyses within a socio-cognitive theory of context can offer new insights into how, first of all, mental models control the process of discourse production and interpretation in important ways, and second, how they are intrinsically related to ideologically based understandings of particular groups and/or situations. Such an approach allows us to account for and explain the potential effectiveness of the discursive moves that emerge from this co-constitutive relationship between contexts and communicative practices.
Institution-independent Ultraproducts

We generalise the ultraproducts method from conventional model theory to an institution-independent (i.e. independent of the details of the actual logic formalised as an institution) framework based on a novel very general treatment of the semantics of some important concepts in logic, such as quantification, logical connectives, and ground atomic sentences. Unlike previous abstract model theoretic approaches to ultraproducts based on category theory, our work makes essential use of concepts central to institution theory, such as signature morphisms and model reducts. The institution-independent fundamental theorem on ultraproducts is presented in a modular manner, different combinations of its various parts giving different results in different logics or institutions. We present applications to institution-independent compactness, axiomatizability, and higher order sentences, and illustrate our concepts and results with examples from four different algebraic specification logics. In the introduction we also discuss the relevance of our institution-independent approach to the model theory of algebraic specification and computing science, but also to classical and abstract model theory.
Brexit and Uncertainty: Insights from the Decision Maker Panel

© 2018 Bank of England. Fiscal Studies © 2018 Institute for Fiscal Studies. The UK's decision to leave the EU in the 2016 referendum created substantial uncertainty for UK businesses. The nature of this uncertainty is different from that of a typical uncertainty shock because of its length, breadth and political complexity. Consequently, a new firm-level survey, the Decision Maker Panel (DMP), was created to investigate this, finding three key results. First, Brexit was reported to be one of the top three sources of uncertainty for around 40percent of UK businesses in the two years after the vote in the June 2016 referendum, and this proportion increased further in Autumn 2018. Hence, Brexit provided both a major and persistent uncertainty shock. Second, uncertainty has been higher in industries that are more dependent on trade with the EU and on EU migrant labour. Third, the uncertainties around Brexit are primarily about the impact on businesses over the longer term rather than shorter term, including uncertainty about the timing of any transition arrangements and around the nature of Brexit.
FOURIER SPACE TIME-STEPPING ALGORITHM FOR VALUING GUARANTEED MINIMUM WITHDRAWAL BENEFITS IN VARIABLE ANNUITIES UNDER REGIME-SWITCHING AND STOCHASTIC MORTALITY

Abstract This paper introduces the Fourier Space Time-Stepping algorithm to the valuation of variable annuity (VA) contracts embedded with guaranteed minimum withdrawal benefit (GMWB) riders when the underlying fund dynamics evolve under the influence of a regime-switching model. Mortality risk is introduced to the valuation framework by incorporating a two-factor affine stochastic mortality model proposed in Blackburn and Sherris (2013). The paper considers both, static and dynamic policyholder withdrawal behaviour associated with GMWB riders and assesses how model parameters influence the fees levied on providing such guarantees. Our numerical experiments reveal that the GMWB fees are very sensitive to regime-switching parameters; a percentage increase in the force of interest results in significant decrease in guarantee fees. The guarantee fees increase substantially with increasing volatility levels. Numerical experiments also highlight an increasing importance of mortality as maturity of the VA contract increases. Mortality has less impact on shorter maturity contracts regardless of the policyholder's withdrawal behaviour. As much as mortality influences pricing results for long maturities, the associated guarantee fees are decreasing functions of maturities for the VA contracts. Robustness checks of the Fourier Space Time-Stepping algorithm are performed by making numerical comparisons with several existing valuation approaches.
Age and obesity alter the relationship between femoral articular cartilage thickness and ambulatory loads in individuals without osteoarthritis

Articular cartilage is sensitive to mechanical loading, so increased risk of osteoarthritis in older or obese individuals may be linked to changes in the relationship between cartilage properties and extrinsic joint loads. A positive relationship has been reported between ambulatory loads and cartilage thickness in young individuals, but whether this relationship exists in individuals who are older or obese is unknown. This study examined the relationship between femoral cartilage thickness and load, measured by weight × height and the peak adduction moment, in young normal‐weight (28 subjects, age: 28.0 ± 3.8 years, BMI: 21.9 ± 1.9 kg/m2), middle‐aged normal‐weight (27 subjects, 47.0 ± 6.5 years, 22.7 ± 1.7 kg/m2), young overweight/obese (27 subjects, 28.4 ± 3.6 years, 33.3 ± 4.6 kg/m2), and middle‐aged overweight/obese (27 subjects, 45.8 ± 7.2 years, 31.9 ± 4.4 kg/m2) individuals. On the lateral condyle, cartilage thickness was positively correlated with weight × height for all groups (R2 = 0.26–0.20) except the middle‐aged overweight/obese. On the medial condyle, weight × height was significantly correlated only in young normal‐weight subjects (R2 = 0.19), as was the case for the correlation between adduction moment and medial–lateral thickness ratio (R2 = 0.20). These results suggest that aging and obesity are both associated with a loss of the positive relationship between cartilage thickness and ambulatory loads, and that the relationship is dependent on the compartment and whether the load is generated by body size or subject‐specific gait mechanics. © 2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 32:394–402, 2014.
Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions

The AML1 gene on chromosome 21 is disrupted in the (8;21)(q22;q22) translocation associated with acute myelogenous leukemia and encodes a protein with a central 118-amino-acid domain with 69% homology to the Drosophila pair-rule gene, runt. We demonstrate that AML-1 is a DNA-binding protein which specifically interacts with a sequence belonging to the group of enhancer core motifs, TGT/cGGT. Electrophoretic mobility shift analysis of cell extracts identified two AML-1-containing protein-DNA complexes whose electrophoretic mobilities were slower than those of complexes formed with AML-1 produced in vitro. Mixing of in vitro-produced AML-1 with cell extracts prior to gel mobility shift analysis resulted in the formation of higher-order complexes. Deletion mutagenesis of AML-1 revealed that the runt homology domain mediates both sequence-specific DNA binding and protein-protein interactions. The hybrid product, AML-1/ETO, which results from the (8;21) translocation and retains the runt homology domain, both recognizes the AML-1 consensus sequence and interacts with other cellular proteins.
Salient Region Detection Using Diffusion Process on a Two-Layer Sparse Graph

Diffusion-based salient region detection has recently received intense research attention. In this paper, we present some effective improvements concerning two important aspects of diffusion-based methods: the construction of the diffusion matrix and the seed vector. First, we construct a two-layer sparse graph, which is generated by connecting each node to its neighboring nodes and the most similar node that shares common boundaries with its neighboring nodes. Compared with the most frequently used two-layer neighborhood graph, our graph not only effectively uses local spatial relationships, but also removes dissimilar redundant nodes. Second, we use the spatial variance of superpixel clusters to obtain the seed vector and, compared with the previously most-used boundary prior, our approach can better distinguish saliency seeds from the background seeds, especially when salient objects appear near the image boundaries. Finally, we calculate two preliminary saliency maps using the saliency and background seed vectors, and more accurate results are obtained using the manifold ranking diffusion method. Integrating these two diffusion-based saliency maps, we obtain the final saliency map. Extensive experiments in which we compare our method with 20 existing state-of-the-art methods on five benchmark data sets: ASD, DUT-OMRON, ECSSD, MSRA5K, and MSRA10K, show that the proposed method performs better in terms of various evaluation metrics.
Russian Investments in the Balkans: Expectations and Realities – the Special Case of Lukoil

Abstract On the basis of the examination of Russian foreign direct investments (FDI) in Balkan countries, the paper investigates the distinctive features, expectations, and realities of Russian capital in the region. Grounding on the case of the leading Russian multinational enterprise (MNE) (Lukoil) investment activity in the Balkans, the study explains the track record of Russian investments in Balkans and discusses the key lessons learned by Russian managers and policy makers in the host countries. The paper facilitates the comparative interregional understanding of Russian FDI and generates practical implications for investments in Balkans. On the basis of the Lukoil case, the paper sheds light on factors influencing investment strategies of Russian MNEs.
Executive function and other cognitive deficits are distal risk factors of generalized anxiety disorder 9 years later

Abstract Objective The cognitive model (Hirsch & Mathews, 2012) and attentional control theory (Eysenck & Derakshan, 2011) postulate that compromised executive function (EF) and other cognitive constructs are negatively linked to increased excessive and uncontrollable worry, the core symptom of generalized anxiety disorder (GAD). However, the prospective link between neuropsychological constructs and GAD are not well understood. Methods A nationally representative sample of 2605 community-dwelling adults whose average age was 55.20 (s.d. = 11.41, range 33–84; 56.31% females) participated at baseline and 9-year follow-up. Baseline neuropsychological function and symptoms were measured using the Brief Test of Adult Cognition by Telephone and Composite International Diagnostic Interview – Short Form. Multivariate Poisson and negative binomial regression analyses were conducted with 11 baseline covariates entered simultaneously: age, gender, years of formal education, perceived control, hypertension/diabetes, body mass index, exercise status, as well as GAD severity, panic disorder severity, and depression severity. Those with baseline GAD were also removed. Results Lower Time 1 composite global cognition z-score independently predicted higher Time 2 GAD severity and diagnosis [odds ratio (OR) 0.60, 95% confidence interval (CI) 0.40–0.89, p = 0.01]. Poor inhibition, set-shifting, working memory (WM) updating, inductive reasoning, and global cognition sequentially forecasted heightened GAD. However, processing speed, verbal WM, verbal fluency, and episodic memory did not predict future GAD. Conclusion Global cognition, inductive reasoning, inhibition, set-shifting, and WM updating EF impairments may be distal risk factors for elevated GAD nearly a decade later.
Production of Chymotrypsin-Resistant Bacillus thuringiensis Cry2Aa1 δ-Endotoxin by Protein Engineering

ABSTRACT Cleavage of the Cry2Aa1 protoxin (molecular mass, 63 kDa) fromBacillus thuringiensis by midgut juice of gypsy moth (Lymantria dispar) larvae resulted in two major protein fragments: a 58-kDa fragment which was highly toxic to the insect and a 49-kDa fragment which was not toxic. In the midgut juice, the protoxin was processed into a 58-kDa toxin within 1 min, but after digestion for 1 h, the 58-kDa fragment was further cleaved within domain I, resulting in the protease-resistant 49-kDa fragment. Both the 58-kDa and nontoxic 49-kDa fragments were also found in vivo when125I-labeled toxin was fed to the insects. N-terminal sequencing revealed that the protease cleavage sites are at the C termini of Tyr49 and Leu144 for the active fragment and the smaller fragment, respectively. To prevent the production of the nontoxic fragment during midgut processing, five mutant proteins were constructed by replacing Leu144 of the toxin with Asp (L144D), Ala (L144A), Gly (L144G), His (L144H), or Val (L144V) by using a pair of complementary mutagenic oligonucleotides in PCR. All of the mutant proteins were highly resistant to the midgut proteases and chymotrypsin. Digestion of the mutant proteins by insect midgut extract and chymotrypsin produced only the active 58-kDa fragment, except that L144H was partially cleaved at residue 144.
The influence of attentive fixation upon the excitability of the light- sensitive neurons of the posterior parietal cortex

We describe the effect of behavioral state upon the excitability of light-sensitive (Ls) neurons of the inferior parietal lobule, area 7a, studied in waking monkeys. The responses of parietal LS neurons to visual stimuli are facilitated during the state of attentive fixation of a target light as compared to their responses to physically and retinotopically identical test stimuli delivered during the eye pauses of alert wakefulness. Seventy percent of the neurons tested (n = 55) showed significant increments in responses in the state of attentive fixation; the median value of the increments was 3.5 times. Only 4 of the 55 cells examined completely showed the reverse relation. Three sets of control experiments were done. The facilitation occurred when the responses evoked during the trials of a reaction task with attentive fixation of a target were compared with those evoked by identical stimuli delivered to the same retinotopic locations at the end of each intertrial interval: the facilitation of attentive fixation is not due to a shift in the general level of arousal. The facilitation occurred when the animal maintained attentive fixation of a spot of the tangent screen without a target light or when an additional light mimicking the target light was presented along with testing stimuli in the state of alert wakefulness without attentive fixation: the facilitation is not produced by a sensory-sensory interaction between target and testing lights. Finally, the facilitation was observed whether or not the test stimuli were behaviorally relevant. We conclude that the act of attentive fixation exerts a specific and powerful effect upon the excitability of the neural systems linking the retinae and the inferior parietal lobule and that the facilitation plays an important role in visually guided behavior.