Miracle-dz/UniFAR-FTUs huggingface dataset:
Basiliximab Versus Daclizumab Combined With Triple Immunosuppression in Deceased Donor Renal Transplantation: A Prospective, Randomized Study

Background. In this prospective, randomized, open-label, single-center study, we compared the efficacy and safety of two anti-interleukin-2 receptor monoclonal antibodies combined with triple immunosuppression. Methods. The adult recipients of at least one human leukocyte antigen-mismatched deceased donor renal graft on cyclosporine microemulsion, mycophenolate mofetil, and methylprednisolone were randomized to induction with basiliximab or daclizumab, given in standard doses. An intent-to-treat analysis of 1-year data assessed the incidence of acute rejections, graft function, patient and graft survival, and safety of this therapy. Results. Two hundred twelve patients were studied. At 12 months, 11 (10.3%) and 10 (9.5%) patients experienced biopsy-confirmed first acute rejection in basiliximab and daclizumab groups, respectively. Estimated glomerular filtration rate was 69±19 mL/min/1.73 m2 in the basiliximab and 66±21 mL/min/1.73 m2 in the daclizumab group. Patient survival was 97.2% with basiliximab and 97.1% with daclizumab, and graft survival was 94.4% vs. 90.5%, respectively. Hospital treatment was required for 50 and 59 infections in basiliximab and daclizumab groups, respectively. One renal cell carcinoma of native kidney and one basal cell carcinoma were detected in the basiliximab group, and one melanoma of skin in the daclizumab group. One hypersensitivity reaction was observed with daclizumab. No significant differences were found between the groups. Conclusion. Basiliximab or daclizumab combined with triple therapy was an efficient and a safe immunosuppression strategy, demonstrated with low incidence of acute rejections, excellent graft function, high survival rates, and acceptable adverse event profile in adult recipients within the 1st year after deceased donor renal transplantation.
Evolving Kolb

In pursuing a refined Learning Styles Inventory (LSI), Kolb has moved away from the original cyclical nature of his model of experiential learning. Kolb’s model has not adapted to current research and has failed to increase understanding of learning. A critical examination of Kolb’s experiential learning theory in terms of epistemology, educational neuroscience, and model analysis reveals the need for an experiential learning theory that addresses these issues. This article re-conceptualizes experiential learning by building from cognitive neuroscience, Dynamic Skill Theory, and effective experiential education practices into a self-adjusting fractal-like cycle that we call Co-Constructed Developmental Teaching Theory (CDTT). CDTT is a biologically driven model of teaching. It is a cohesive framework of ideas that have been presented before but not linked in a coherent manner to the biology of the learning process. In addition, it orders the steps in a neurobiologically supported sequence. CDTT opens new avenues of research utilizing evidenced-based teaching practices and provides a basis for a new conversation. However, thorough testing remains.
The influence of the best practices of information system development on software SMEs: a research scope

The sustainable success of any organisation is strongly associated with the success of Information System (IS) projects, as ISs are considered an important component of flexibility for all kind of enterprises. Organisations are investing extensively on ISs to get the maximum benefits of Information Technology (IT) in today's competitive business set-up. Despite significant efforts to improve IS projects' success, many ISs tend to be unsuccessful most of the time. The reasons sought are the lack of alignment between IS planning and business planning, a huge divergence in the approaches adopted for the development of ISs due to time, cost and environmental factors and the ignorance of most enterprises (especially Small and Medium-sized Enterprises or SMEs) of project management practices. No method gives standards for the development of ISs in SMEs, which results in a sharp decline of the long-term performance of ISs. This paper presents the influence of the best practices of IS development and project management on IS projects, especially in software SMEs, considering a strong relation between IS success and the success of any business process.
Staphylococcus aureus

Summary A strain of staphylococci in becoming resistant to penicillin did not show an increase in its resistance to sulfactin. A similar strain of staphylococci in becoming resistant to sulfactin did not show an increase in its resistance to penicillin. The increase in resistance to sulfactin developed by the strain of staphylococci was intermediate between the increment in resistance developed by staphylococci to penicillin and the increase in resistance developed by a strain of E. coli to streptomycin.
Antibody-Dependent Cellular Cytotoxicity against Primary HIV-Infected CD4+ T Cells Is Directly Associated with the Magnitude of Surface IgG Binding

ABSTRACT Antibody (Ab)-dependent cellular cytotoxicity (ADCC) is thought to potentially play a role in vaccine-induced protection from HIV-1. The characteristics of such antibodies remain incompletely understood. Furthermore, correlates between ADCC and HIV-1 immune status are not clearly defined. We screened the sera of 20 HIV-1-positive (HIV-1+) patients for ADCC. Normal human peripheral blood mononuclear cells were used to derive HIV-infected CD4+ T cell targets and autologous, freshly isolated, natural killer (NK) cells in a novel assay that measures granzyme B (GrB) and HIV-1-infected CD4+ T cell elimination (ICE) by flow cytometry. We observed that complex sera mediated greater levels of ADCC than anti-HIV-1 envelope glycoprotein (Env)-specific monoclonal antibodies and serum-mediated ADCC correlated with the amount of IgG and IgG1 bound to HIV-1-infected CD4+ T cells. No correlation between ADCC and viral load, CD4+ T cell count, or neutralization of HIV-1SF162 or other primary viral isolates was detected. Sera pooled from clade B HIV-1+ individuals exhibited breadth in killing targets infected with HIV-1 from clades A/E, B, and C. Taken together, these data suggest that the total amount of IgG bound to an HIV-1-infected cell is an important determinant of ADCC and that polyvalent antigen-specific Abs are required for a robust ADCC response. In addition, Abs elicited by a vaccine formulated with immunogens from a single clade may generate a protective ADCC response in vivo against a variety of HIV-1 species. Increased understanding of the parameters that dictate ADCC against HIV-1-infected cells will inform efforts to stimulate ADCC activity and improve its potency in vaccinees.
A Sanctuary for cancer cells: Microenvironment in T-cell acute lymphoblastic leukemia survival and drug resistance

T-cell acute lymphoblastic leukemia (T-ALL) is a heterogeneous malignancy associated with a high risk of treatment failure. Efforts to improve outcomes have focused on underlying genetic defects. However, strong evidence suggests that leukemic cells prime a maladapted niche that in turn provides signals capable of sustaining the dormancy of leukemia initiating cells and protects them from toxic chemotherapeutic agents. Here, we aim to describe how key components of the bone marrow microenvironment are essential for leukemia initiation and progression. Although many mechanisms have been recently discovered, further studies are required to fully dissect the molecular mechanisms governing the bidirectional interactions between tumor and host cells. We predict that these new discoveries will pave the way for the implementation of novel therapeutic strategies and will eventually lead to the eradication of the drug-resistant cells, substantially and ultimately enhancing cure rates for T-ALL patients. Correspondence to: Filomena Di Giacomo, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA; E-mail: fid2002@med.cornell. edu
Consumption Poverty and Pro-Poor Growth in Bolivia

Using seven Bolivian household surveys conducted between 1999 and 2007, this paper provides a different picture of poverty dynamics in Bolivia. Consistent and accurate estimates of consumption are computed and used to create poverty profiles. Challenging the previous income-based poverty trend, it emerges that Bolivia experiences a very large poverty reduction from 2002 onwards, halving poverty headcount during the period of 2002- 2007. Growth incidence curves are also used to investigate the pro-poor component of the large welfare improvement. It shows that the poorest quintiles of the population, mostly represented by indigenous households, did benefit more than the rest of the population. The results suggest that Bolivian pro-poor growth significantly contributed to narrow the welfare inequality between indigenous and non-indigenous groups.
A Comparison of Nutritional Management with Stress Management in the Treatment of Bulimia Nervosa

In a comparison of nutritional management (NM) and stress management (SM) for treatment of bulimia nervosa, 55 female patients were randomly assigned to either treatment. Therapy consisted of 15 sessions in a group over three months, by the end of which, patients under both treatment conditions showed a significant reduction in the frequency of binge eating and vomiting and a significant improvement in various psychopathological features such as body dissatisfaction and depression. All improvements were maintained over 12–month follow-up. NM produced a more rapid improvement in general eating behaviour, a faster reduction in binge frequency and a higher abstinence rate from binge eating. SM led to greater positive changes in certain psychopathological features such as feelings of ineffectiveness, interpersonal distrust and anxiety. NM should be regarded as a necessary first intervention in all bulimic patients. Further psychological therapy, such as SM, is indicated as well for some patients, depending on their specific psychological difficulties.
Participation of people with acquired brain injury: Insiders perspectives

Introduction: Participation is important in rehabilitation of people with acquired brain injury (ABI). Studies have shown that their participation is problematic. It is, however, unknown how they experience their participation and what influences their participation. This study aims to answer the question how people with ABI experience participation and which environmental and personal factors may influence participation, as perceived by people with ABI. Methods: A qualitative methodology was conducted by a team consisting of researchers, people with ABI and a mother of a daughter with ABI. Interviews and focus groups were held and followed by a working group in order to develop actions for improvement. Results and conclusion: People with ABI contend that it is not the degree of participation that matters, but the quality of participation. They describe meaningful participation in terms of taking part, giving something and being someone. A model was constructed based on the experiences, which includes personal and environmental factors that, in interaction, may influence participation: participation is influenced by the process of recovery, support and treatment, the environment and society and communication and interaction. The study resulted in an overview of actions like continual care that may improve the participation of people with ABI.
Moving Schemes for Mobile Sinks in Wireless Sensor Networks

In a wireless sensor network for data-gathering applications, if all network data congregate to a stationary sink node hop by hop, the sensor nodes near the sink have to consume more energy on forwarding data for other nodes, which probably causes the early function loss of the sensor network. Employing a mobile sink can alleviate the hotspot problem and balance the energy consumption among the sensor nodes. In this paper, we propose two autonomous moving schemes for the mobile sink. In our schemes, the sink makes moving decisions without complete knowledge of network topology and the energy distribution of all sensor nodes. We evaluated the performance of our moving schemes by simulation and the results show that both the two schemes can extend the network lifetime prominently.
What Is the National Burden of Sepsis in U.S. Emergency Departments? It Depends on the Definition.

Critical Care Medicine www.ccmjournal. org 1569 need for two separate diagnoses. Current understanding of the two disorders has not, to date, identified a fundamental difference in the underlying pathobiology. Treatment is, or should be, identical. Indeed, the label “septic shock” may be of epidemiologic value only—based on current understanding, septic shock is basically just “really, really, really bad” sepsis. In summary, the study by Sterling et al (5) is instructive, but perhaps not in the way intended. It again demonstrates the differences between “definitions” and “clinical criteria. ” And, more importantly, it points out the dangers inherent in incomplete examination of data and in treating labels or diagnoses instead of patients. Continued validation and improvement of the Sepsis-3 criteria are essential, but it is equally essential these efforts encompass the entire spectrum of disorder and not just pieces of it.
The Female Sexual Function Index (FSFI): validation of the Malay version.

INTRODUCTION Female sexual dysfunction (FSD) is a prevalent sexual health problem that has been inadequately investigated in Malaysia, a nation with a conservative multiethnic society. AIM To validate the Malay version of the Female Sexual Function Index (MVFSFI) for the study of FSD. MAIN OUTCOME MEASURE To measure the validity and reliability of the MVFSFI and its domains. METHODS Validation was carried out on aspects of face, content, discriminant, and criterion (concurrent) validity. Reliability studies on test-retest and on internal consistency were conducted with Cronbach's alpha and Pearson correlation, respectively. The values with the highest sensitivity and specificity generated from the receiver operating characteristic curves were taken as the cutoff scores to differentiate cases and noncases. RESULTS A total of 230 married women aged 18-70 years participated in this study. There was a high test-retest correlation by respondents (r at least >0.7). The MVFSFI was found to have good discriminant validity as a whole and for each domain. A total score of 55 was taken as the cutoff point for the MVFSFI to distinguish between women with sexual dysfunction and those without (sensitivity = 99%, specificity = 97%). Scores lower than 55 indicate sexual dysfunction. The cutoff score for each domain was also established for the MVFSFI: </=5 for sexual desire disorder (sensitivity = 95%, specificity = 89%); </=9 for sexual arousal disorder (sensitivity = 77%, specificity = 95%); </=10 for disorder of lubrication (sensitivity = 79%, specificity = 87%); </=4 for orgasmic disorder (sensitivity = 83%, specificity = 85%); </=11 for sexual dissatisfaction (sensitivity = 83%, specificity = 85%); and </=7 for sexual pain disorder (sensitivity = 86%, specificity = 95%). CONCLUSION The MVFSFI is a validated and locally accepted questionnaire for use in the assessment of FSD in the Malaysian population.
Enhanced Nonsaturable Calcium Transport in the Jejunum of Rats During Lactation, but Not During Pregnancy

The lactating (L) rat loses in excess of 100 mg of calcium (Ca) per day to milk at peak lactation. Most of the Ca must be provided by increased intestinal absorption. In an effort to examine adaptation of intestinal calcium absorption during lactation, nonsaturable absorption from the small intestine of rats was calculated from the disappearance of Ca from in situ ligated loops of jejunum during the last week of pregnancy and throughout lactation and weaning. Efficiency of absorption is reflected by the slope of the regression line of Ca absorbed on Ca introduced into the loop. Absorption of Ca in the jejunum was markedly enhanced starting at 5 days of lactation and for the remainder of lactation. Two days after weaning, the efficiency of jejunal Ca absorption decreased to the nonmated (NM) control level, while the lactation‐associated intestinal hypertrophy persisted beyond 2 days postweaning. The percentages of water and Ca absorbed were positively and significantly correlated in both L and NM rats. In contrast to Ca, magnesium (Mg) and strontium (Sr) transport from ligated loops were not enhanced during lactation. Fifty millimolar glucose in the test solution increased the absorption of both water and Ca, but not Mg, from jejunal loops of NM rats. Glucose increased Ca absorption in NM rats up to the level seen in L rats. Glucose did not increase Ca absorption further in L rats, perhaps because of the greater availability of glucose to the intestine during lactation. We conclude that in rats the efficiency of nonsaturable Ca absorption from the jejunum is significantly increased during well established lactation, but not during pregnancy. The underlying mechanism appears to be specific for Ca, may be dependent on glucose, and is unrelated to intestinal hypertrophy.
Decreased susceptibility of peripheral blood mononuclear cells from individuals heterozygous for a mutant CCR5 allele to HIV infection.

OBJECTIVE Individuals homozygous for a deletion in the CCR5 gene (CCR5delta32/CCR5delta32) are resistant to HIV infection, indicating that this particular chemokine receptor plays a crucial role in the initiation of in vivo HIV infection. We investigated the effect of the heterozygote genotype (CCR5/CCR5delta32) on susceptibility of peripheral blood mononuclear cells (PBMC) to HIV infection. DESIGN Sensitivity to HIV infection of PBMC from volunteers with either the CCR5/CCR5, CCR5/CCR5delta32, or CCR5delta32/CCR5delta32 genotypes was examined by challenging their PBMCs with serial titers of HIV isolates with different cellular tropisms. The genotype of the PBMCs was correlated with the lowest viral inoculum required to initiate productive infection with either three M-tropic HIV-1 isolates, (92RW009A, HIV-1ada, and HIV-1(59)), one dual-tropic HIV-1 isolate (92BR021), or two T-tropic HIV-1 isolates (92UG021 and 92UG029). RESULTS PBMCs from the CCR5/CCR5delta32 group required a significantly higher inoculum (p value from .036 to .003) to become infected with these three M-tropic HIV-1 isolates than did PBMC from the CCR5/CCR5 group, but became infected after exposure to an inoculum of T-tropic HIV-1 isolates that was comparable to that which infected PBMCs from the CCR5/CCR5 individuals. CONCLUSIONS The decreased susceptibility of PBMCs from individuals heterozygous for the CCR5 deletion to HIV infection by M-tropic HIV-1 isolates may provide a mechanistic explanation for the delayed progression of disease in some CCR5/CCR5delta32 individuals.
TOLL-LIKE RECEPTOR 4-DEPENDENT RESPONSES TO LUNG INJURY IN A MURINE MODEL OF PULMONARY CONTUSION

Blunt chest trauma resulting in pulmonary contusion with an accompanying acute inflammatory response is a common but poorly understood injury. We previously demonstrated that toll-like receptor 2 (TLR-2) participates in the inflammatory response to lung injury. We hypothesized that the TLR-4, in an MyD88-dependent manner, may also participate in the response to lung injury. To investigate this, we used a model of pulmonary contusion in the mouse that is similar to that observed clinically in humans and evaluated postinjury lung function, pulmonary neutrophil recruitment, and the systemic innate immune response. Comparisons were made between wild-type mice and mice deficient in TLR-4 or MyD88. We found TLR-4-dependent responses to pulmonary contusion that include hypoxemia, edema, and neutrophil infiltration. Increased expression of IL-6 and chemokine (C-X-C motif) ligand 1 in the bronchoalveolar lavage and serum was also dependent on TLR-4 activation. We further demonstrated that these responses to pulmonary contusion were dependent on MyD88, an adapter protein in the signal transduction pathway mediated by TLRs. These results show that TLRs have a primary role in the response to acute lung injury. Lung inflammation and systemic innate immune responses are dependent on TLR activation by pulmonary contusion.
Developing the Yearning in Situations of Loss Scale: Convergent and Discriminant Validity for Bereavement, Romantic Breakup, and Homesickness

Yearning is common in situations involving loss, and a hallmark of complicated grief. To study yearning empirically, the present study develops the Yearning in Situations of Loss scale (YSL), which measures yearning bereavement, romantic breakup, or homesickness. In Study 1, we identified shared characteristics across situations of loss, tested an initial version and removed items with the lowest item-scale reliability. In Study 2, the 21-item YSL was compared to scales of anxiety, depression, and loneliness, and existing scales, relevant to each loss situation. The YSL showed discriminant and convergent validity that applies to bereavement, romantic breakup, and homesickness.
Highly cited articles in the Information Science and Library Science category in Social Science Citation Index: A bibliometric analysis

This study aims to identify and analyse the characteristics of highly cited articles published in the Information Science and Library Science category in the Social Science Citation Index. Articles that have been cited at least 100 times since publication up to the end of 2012 were analysed. We identified 501 highly cited articles published between 1956 and 2009 in 37 journals. MIS Quarterly published 26% of all analysed highly cited articles. The most productive researcher published 11 articles. Six bibliometric indicators were used to evaluate source institutions and countries. The 13 most productive institutions were all located in the USA and Canada. Harvard University in the USA was the most productive institution, ranked number one in the total number of highly cited articles, while the University of Maryland in the USA had the highest publication performance of first and corresponding author articles. Researchers from the USA contributed 67% of highly cited articles.
Association between the prominence of the articular eminence and displaced TMJ disks.

AbstractIn this study, the authors used protrusive condylar path tracings to indicate the relative prominence (or steepness) of TMJ articular eminences in 29 joints with anteriorly displaced disks with reduction (Group 1), and in 326 normal joints (Group 2). The average protrusive condylar path for Group 1 was 63.1° as compared with 50° for Group 2 (significant at the 1% level). In addition, for 13 subjects with unilaterally displaced disks, the average condylar path of the involved joints was 64.1°, compared to 49.1° for the uninvolved joints (significant at the 1% level). The authors speculate that a prominent articular eminence may in conjunction with other factors, predispose a subject to internal derangement of the TMJ.
Rod electrical coupling is controlled by a circadian clock and dopamine in mouse retina

Rod photoreceptors play a key role in vision in dim light; in the mammalian retina, although rods are anatomically connected or coupled by gap junctions, a type of electrical synapse, the functional importance and regulation of rod coupling has remained elusive. We have developed a new technique in the mouse: perforated patch‐clamp recording of rod inner segments in isolated intact retinae maintained by superfusion. We find that rod electrical coupling is controlled by a circadian clock and dopamine, and is weak during the day and stronger at night. The results also indicate that the signal‐to‐noise ratio for a dim light response is increased at night because of coupling. Our observations will provide a framework for understanding the daily variations in human vision as well as the basis of specific retinal malfunctions.