Miracle-dz/UniFAR-FTUs huggingface dataset:
Comprehensive Prediction Model of Urinary Incontinence One Year following Robot-Assisted Radical Prostatectomy

Objectives: Urinary incontinence (UI) still remains one of the major functional complications after robot-assisted radical prostatectomy (RARP). As the cause for UI is multifactorial, it is quite difficult to make a prediction preoperatively. Considering intraoperative and postoperative risk factors, besides the preoperative ones, we designed an incontinence prediction model, administered 1 month after the surgery, in order to identify incontinent patients at 1 year. Patients and Methods: We retrospectively reviewed 244 patients who underwent RARP at our institution. Only 209 patients had sufficient data, a 1-year follow-up and were continent preoperatively. The association of UI with the risk factors was assessed by univariable and multivariable regression models. Results: There was a 17.2% global UI rate at 1 year after RARP. Only age-adjusted Charlson comorbidity index, erectile function assessed by International Index of Erectile Function-5, prostate volume, nerve-sparing status and 24-hour urine loss at 1 month correlated with UI (p = 0.032, 0.009, 0.031, 0.018 and <0.001, respectively). The accuracy of the prediction model of UI was 92.8% (c-index), with an area under the curve of 91.9%. Conclusion: Age-adjusted Charlson comorbidity index, International Index of Erectile Function-5, prostate volume, nerve-sparing status and 24-hour urine loss at 1 month after RARP can predict an individual’s risk of UI at 1 year after RARP with good accuracy. Further external validation is required in order to generalize the use of this model.
Estimation of genetic parameters for egg production traits in Japanese quail (Coturnix cot. japonica

Keeping Japanese quail is an economic way for producing egg, because of their early sexual maturity (laying egg after 35 days), high egg production (250–270 eggs per year), resistance to most of poultry disease and great egg production persistency on a high level (approximately 14–18 months) (MURAKAMI and ARIKI, 1998). Japanese quail maturation happens in about 6 weeks of age and mature females are usually in full egg production by 50 days of age. With proper care, hens should lay more than 200 eggs in their first year of lay. The average egg weighs about 10–15 g which is about 8% of female body weight. Feed conversion for egg production in Japanese quail is better than in laying hens. Quail hens need less than 2 kg of feed to produce 1 kg of egg, while laying hens need between 1.9 to 2.5 kg of feed to make the same amount of egg. Japanese quail eggs are nearly identical in taste and nutritional quality to chicken eggs. There is an expanding market for products such as fresh or pickled quail eggs in Asian, American and some European countries (MINVIELLE, 2004). Egg production performance is usually assessed in poultry through age (ASM) and weight at sexual maturity (WSM), mean egg weight (MEW) and egg number (EN) during certain production periods (KIANIMANESH, 2000). ASM and WSM are considered as criterions for sexual maturity in birds and refer to age and weight at first egg, respectively. ASM and WSM together with EN and MEW are the most important economic traits in laying birds. Genetic improvement for egg production would increase the production efficiency and profitability of Japanese quail. The possibility of genetic improvement by selection depends on genetic variability of laying performance traits. For genetic evaluation, it is necessary to estimate heritability and genetic correlations between egg production traits. There are some detailed studies on estimation of variance components for egg production traits in Japanese quail (NESTOR et al., 1983; MINVIELLE et al., 1997; MINVIELLE and OGAZ, 2002; SAATCI et al. 2006, KHALDARI et al., 2010; HIDALGO et al., 2011). Considering the importance of such studies in quails, present research was conducted to estimate heritability, genetic and phenotypic correlations of ASM, WSM, MEW and EN from 9 to 12 weeks of age and
Field of Study and Employment Outcomes: An Analysis of Tafe Graduates

An important aim of the vocational educational and training system is to improve the employability and employment outcomes of students. The TAFE Student Outcomes Survey allows an investigation of the factors associated with employability of different individuals. Significantly for policy makers, it provides data on the course of study undertaken and institute attended. This paper models the probability that a TAFE student is employed as opposed to unemployed in the following year after graduation. It is found that non-English speaking background and disabled students have significantly lower employment outcomes than other students. One field of study, science—which includes mostly information technology courses—was associated with lower employment prospects than others. A tentative conclusion is drawn that higher-level qualifications result in better employment outcomes.
A genome-wide resource for the analysis of protein localisation in Drosophila

The Drosophila genome contains >13,000 protein coding genes, the majority of which remain poorly investigated. Important reasons include the lack of antibodies or reporter constructs to visualise these proteins. Here we present a genome-wide fosmid library of ≈10,000 GFP-tagged clones, comprising tagged genes and most of their regulatory information. For 880 tagged proteins we have created transgenic lines and for a total of 207 lines we have assessed protein expression and localisation in ovaries, embryos, pupae or adults by stainings and live imaging approaches. Importantly, we can visualise many proteins at endogenous expression levels and find a large fraction of them localising to subcellular compartments. Using complementation tests we demonstrate that two-thirds of the tagged proteins are fully functional. Moreover, our clones also enable interaction proteomics from developing pupae and adult flies. Taken together, this resource will enable systematic analysis of protein expression and localisation in various cellular and developmental contexts.
Syndicated Loans, Lending Relationships and the Business Cycle

The syndicated loan market, as a hybrid between public and private debt markets, comprises financial institutions with access to valuable priv ate information about borrowers as a result of close bank-borrower relationships. In this paper , we seek empirical evidence for the costs of these relationships in a sample of UK syndicated loan contracts for the time period 1996 through 2005. Using detailed financial data for bot h borrowers (private and public companies) and for financial institutions, we find that underc apitalized banks charge higher loan spreads for loans to opaque borrowers using various measure s for borrower opaqueness and controlling for bank, borrower and loan characteris tics. We further analyze this hold-up effect over the business cycle and find that it only preva ils during recessions. In expansion phases, however, we do not find evidence for banks exploiti ng their information monopoly. This finding is consistent with theories on bank reputat ion in bank loan commitments. Ambiguity about borrower financial health, which induces the information monopoly in the first place, also gives banks the discretion to exploit or not e xploit informational captured borrowers. Our findings are both statistically and economically si gnificant and robust to alternative bank and macroeconomic risk proxies. We address potential concerns about unobserved borrower heterogeneity exploiting the panel data nature of o ur sample. Using firm-bank fixed effect regressions, we find supporting evidence for our th eoretical framework.
A Survey of Information Retrieval on Microblog

Twitter is most popular microblogging site. It provide us with real time data. This article Provide survey of techniques for retrieving information from twitter stream. This techniques aim is finding real world and most relevant information with respect to the query. For retrieve most relevant information used query expansion techniques. Twitter data contain large amount of information. Information rank retrieval techniques find important data and gives the final score to that information with respect to user interest profile
PCP theorem : gap amplification

In this note, we prove the following theorem, which is a major step toward a proof of the PCP theorem. Recall that in the optimization problem 2-CSPW, we are given a list of arity-2 constraints between variables over an alphabet of size W and the goal is to find an assignment to the variables that satisfies as many of the constraints as possible. A 2-CSPW instance φ is d-regular if every variable of φ appears in exactly d of the constraints of φ. It turns out that there is an efficient reduction to transform general instances of 2-CSPW to d-regular ones without significantly affecting the optimal value of the instance.
Humanism in Medical Education: A Study of Educational Needs Perceived by Trainees of Three Canadian Schools

Abstract The authors examined how medical trainees and recent graduates of three Quebec medical schools value 16 dimensions of medical competence classified in four broad categories: clinical, technological, humanistic, and social and preventive. To assess perceived educational needs, the trainees' perceptions of the importance that medical faculties attribute to these same dimensions in the education of physicians were also examined. The survey was conducted in 1986–87 via a questionnaire mailed to 2,030 individuals, including freshmen, juniors, interns, residents, and newly practicing generalists; 80.3% responded. Compared with the views attributed to the faculty, the medical trainees gave more importance to basic diagnostic and therapeutic skills such as the medical history, the physical examination, and the treatment of common diseases. They also valued to a greater extent non‐biological dimensions of clinical competence, such as communication with patients, patient education, the social context of disease, and the multidisciplinary nature of patient care, while they ascribed less importance to medical technology and rare diseases. The study raises the question of the relevance of medical education to medical practice by suggesting that those who are preparing them‐selves to become doctors may not be receiving the training they wish to receive. Acad. Med. 65(1990):41–45.
Onion extract (Allium cepa L.), quercetin and catechin up-regulate paraoxonase 1 activity with concomitant protection against low-density lipoprotein oxidation in male Wistar rats subjected to oxidative stress.

BACKGROUND Paraoxonase 1 (PON1) protects the oxidative modification of low-density lipoprotein (LDL) and is a major anti-atherosclerotic protein component of high-density lipoprotein. We explored the effect of onion extract and flavonoids (quercetin and catechin) in the regulation of PON1 expression and correlating with oxidised LDL levels in male Wistar rats subjected to mercuric chloride (HgCl₂) induced oxidative insult. Rats were divided into eight groups: Control, Experimental (HgCl₂), Experimental + onion/catechin/quercetin, Positive control (Normal + onion/catechin/quercetin). Treatment continued for 4 weeks. RESULTS PON1 activity and radical scavenging activity decreased in the Experimental group (P < 0.001) with increased susceptibility of LDL for oxidation and plasma malondialdehyde levels (P < 0.001). Onion extract significantly attenuated the adverse effects of HgCl₂ by up-regulating PON1 activity (P < 0.05), radical scavenging activity (P < 0.01), and protected against LDL oxidation (P < 0.001) and lipid peroxidation (P < 0.01). Similar effects were observed with quercetin and to a lesser extent with catechin. CONCLUSIONS The findings may explain the anti-atherosclerotic effect of onion and also foods containing quercetin and catechins.
Consumer Flexibility, Data Quality and Targeted Pricing

We investigate how firms' incentives to acquire customer data for targeted offers depend on its quality. A two-dimensional Hotelling model is proposed where consumers are heterogeneous both with respect to their locations and transportation cost parameters (flexibility). Firms have perfect data on the locations of consumers while data on their flexibility is imperfect. When consumers are relatively homogeneous in their flexibility, in equilibrium both firms acquire customer data regardless of its quality. This increases profits but harms consumers. When consumers are relatively differentiated in flexibility, data acquisition incentives depend on its quality. Only if the data is sufficiently precise, both firms acquire it and their profits decrease, while consumers are better-off. Our model has particular relevance for location-based marketing such as in mobile telephony, where firms have near-perfect information on the proximity of customers but may have imperfect knowledge of other consumer characteristics.
Functional Radiographic Diagnosis of the Lumbar Spine: Flexion—Extension and Lateral Bending

Several attempts have been made to measure the segmental range of motion in the lumbar spine during flexion–extension with the purpose of gathering additional data for the diagnosis of instability. The previous studies were performed in vitro or in vivo during active motion. The aim of this study was to obtain normal values of passively performed segmental motions. Forty-one healthy adults were examined by means of functional radiographs during flexion–extension and lateral bending. A graphic construction method and a computerassisted method were used to measure rotations. Comparing with recent in vivo studies, the values obtained for normal angles of rotation were predominately larger. This might be due to the passive examination used in the study. The graphic construction method and computerassisted method techniques are equally reliable, but the computer-assisted method method yields other important kinematic data, such as translations. It is proposed that passive motion be applied during functional examination of patients with suspected instabilities. However, the large variation of rotational values between individuals in the normal population may limit the clinical usefulness of functional lumbar analysis using this parameter. Future studies should explore the clinical relevance of determining altered segmental mobility in low-back pain patients.
Amyotrophic lateral sclerosis and spinocerebellar ataxia type 2 in a family with full CAG repeat expansions of ATXN2.

IMPORTANCE A family with coexistence of spinocerebellar ataxia type 2 and amyotrophic lateral sclerosis (ALS) is described. OBSERVATIONS Intermediate or full CAG repeat expansions of ATXN2 are associated with ALS. However, no coexistence of spinocerebellar ataxia type 2 and ALS in a family has been reported in the literature.We describe a 47-year-old woman with an 11-year history of ataxia and her paternal uncle with ALS who were evaluated at Columbia University Medical Center since July 2006. Both our patient with ataxia and her uncle with ALS have full pathological CAG repeat expansions of ATXN2. CONCLUSIONS AND RELEVANCE The diverse clinical phenotypes of ATXN2 CAG expansions and their coexistence in a single family are highlighted. A clinician should consider the diagnosis of spinocerebellar ataxia type 2 when encountering a patient with ataxia and a family history of ALS.
Size and relatedness of units sold: An agency theory and resource‐based perspective

This study tests the effects of ownership concentration, outside director equity holdings, and corporate strategy on, and the Performance implications of, the size and relatedness of units sold by parent firms. The study is based on a model that integrates agency and resource‐based theories, and a sample of sell‐offs by 112 Fortune 500 firms. Ownership concentration is found to be associated positively with the sale of unrelated and small units. This relationship is strengthened when outside director equity is high. In addition, the effects of corporate strategy types on the characteristics of units sold depend on ownership concentration and outside director equity. Finally, post'sell‐off performance of the parent firm is associated negatively with the relatedness of the unit sold. These results suggest that the type of unit sold depends on the type of economic benefit sought by the parent firm.
Long-term Outcomes in Steroid-refractory Ulcerative Colitis Treated with Tacrolimus Alone or in Combination with Purine Analogues.

BACKGROUND AND AIMS Tacrolimus is recommended for the treatment of steroid-refractory ulcerative colitis (UC). Concomitantly started purine analogues (PAs) are used for the maintenance of remission, though their therapeutic relevance remains uncertain. Here we studied the role of PAs in the long-term outcome of steroid-refractory UC after tacrolimus treatment. METHODS In five centres, charts of tacrolimus-treated UC patients with a steroid-refractory moderate to severe course were reviewed. Long-term efficacy was determined by colectomy rates and clinical remission in cases of colectomy-free survival for 3 months. RESULTS We identified 156 patients (median age 34 years) with a median Lichtiger score of 12 (4-17) and pancolitis (E3) in 65% (101). The Kaplan-Meier curve for colectomy-free survival after month 3 showed a benefit in the PA group (p = 0.02). In patients treated with PA clinical remission was achieved in 82% (65/79) vs 67% (39/58) in those not treated with PA (p = 0.02). Time to colectomy was 2 years (median, 0.7-5.8) in the PA group and 0.8 years (0.3-4.7) in the group not treated with PAs (p = 0.02). Time to relapse was 1.2 years (median, 0.3-6.2) in patients with PA treatment and 0.5 years (0.3-3.9) in those without PA treatment (p = 0.05). Overall, clinical remission was achieved in 67% (104/156) of patients. Colectomy was performed in 29% (45/156) 0.5 years (median, 0.04-5.79) after initiation of tacrolimus. Ten (6%) patients had to stop tacrolimus due to adverse events and two (without PA treatment) died. CONCLUSIONS Our study supports the efficacy of tacrolimus in steroid-refractory UC. Purine analogues appear to be beneficial for the long-term outcome of these patients.
LYMPHATIC DRAINAGE AND ADJUVANT-INDUCED ARTHRITIS IN RATS.

THE arthritic syndrome which develops in rats after intradernal injections of Freund's adjuvant (a fine suspension of dead mycobacteria in liquid paraffin), into certain sites has been previously described (Stoerk, Bielinski and Budzilovich, 1954; Pearson, 1956, 1959; Houssay and Frangione, 1961 Ward and Newbould, 1963). The most striking feature of this syndrome is the development of inflamed lesions called secondary lesions, remote from the injection site, after a delay of approximately 10 days. Waksman, Pearson and Sharp (1960) have suggested that the disease process represents a delayed hypersensitivity response to a disseminated antigen, probably derived from the tubercle bacillus but detailed knowledge of the steps involved is lacking. hr. adjuvant
Investigation on Die Shift Issues in the 12-in Wafer-Level Compression Molding Process

Die shift issues that arise in embedded wafer-level packaging because of the mold flow process is investigated in this paper, along with solution strategies to address them. The nonlinearity trend of the die shift in the experimental inspection is explained and captured by the numerical simulation with a consideration of the coefficient of thermal expansion effect coupled with the mold flow effect. Optimizing the initial diameter of molding compounds, increasing the thickness of molding compounds, and reducing the filling speed are the three solutions we demonstrate for reducing the drag force. Die shift generated by the mold flow could be reduced by optimizing these controllable parameters.
AC Resistance of ACSR-Magnetic and Temperature Effects

In 1981, the Working Group on Calculation of Bare Overhead Conductor Temperatures formed a Task Group on the Resistance of Bare Overhead Stranded Conductors for the purpose of evaluating present methods of calculating resistance. The Task Group determined that standard methods of calculating resistance were quite adequate except for two possible problems -- the correction for magnetic core losses in ACSR conductor and the possibility of significant radial temperature gradients.
Developing stroke rehabilitation and community services: a meta-synthesis of qualitative literature

Purpose: To identify the key factors that are necessary to account for in planning and developing rehabilitation and community services for stroke based on users’ perspectives. Method: A meta-synthesis of qualitative research comprising three stages: (i) systematic searching and identification of relevant reports; (ii) critical appraisal of selected reports; (iii) analysis and synthesis of included reports. Results: A total of 138 reports were identified, 101 were rejected after applying the inclusion criteria. Following critical appraisal, 18 papers were included. The main interconnecting themes relate to how the impact of stroke is influenced by: (i) the person; (ii) close social relationships; (iii) the social environment; (iv) interactions between all three. The lines-of-argument synthesis relates to the social world a person inhabits and its effect on how a person will perceive and deal with their stroke. Support will be most effective when delivered in the context of this social world. Conclusion: How stroke is perceived is highly dependent on a person’s identity. Support can be effective if delivered within the existing structures of a stroke survivor’s unique social world. Implications for Rehabilitation Rehabilitation of stroke survivors needs to be considered in its broadest context and include an equal focus on the social, psychological and physical aspects. Traditional rehabilitation practice needs to be expanded if stroke survivors are to be supported in maintaining an active and positive presence in their unique social world.
Genetic Polymorphism of the Glutathione S-Transferase M1 and Development of Breast Cancer

Glutathione S-transferases (GSTs) are encoded by a superfamily of genes and play a role in the detoxification of potential carcinogens. The human GSTs are divided into four classes: alpha, mu, pi and theta. Previous studies indicated that the absence of the Glutathione S-Transferase M1 (GSTM1) protein correlated with an increased risk of developing some types of cancers. Association between specific genotype and the development of breast cancer is still an open question. In the present study, the association between genetic polymorphism in the GSTM1 and susceptibility to breast cancer was investigated. The genetic polymorphism of the GSTM1 in exon 5 to exon 6 segments was detected by PCR in 59 patients with breast cancer and 59 normal subjects. The frequency of the GSTM1 null genotype in control and patient groups was 39.0% and 50.8% respectively. There was no significant association between null genotype of the GSTM1 and susceptibility to breast cancer (X 2 = 1.63, df = 1,