Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinical, Electrophysiological, and Histopathological Observations in Supraventricular Tachycardia

Fifty patients with supra ventricular tachycardia (SVT) underwent clinical electrophysiological studies (EPS), endomyocardial biopsies und cardiac catheterizations. EPS revealed AV nodal reentrant tachycardia (AVNRT) in seven patients, AV reentrant tachycardia utilizing concealed AV bypass tracts (AVR‐ CBT) in nine patients, AV reentrant tacycardia utilizing AV bypass tracts with ventricular preexcitation (manifest WPW) in 13 patients, sinus nodal or intra‐atrial reentrant tachycardia (SNRT or TART) in three patients, atrial flutter (AF) in nine patients, automatic atrial tachycardia (AAT) in jive patients, and multifocal atrial tachycardia (MAT) in four patients. According to the clinical observations, three patients with AVNRT (43%), six with AVH‐CBT (67%), six with manifest WPW (46%), two with SNRT or IART (67%), eight with AF (89%), two with AAT (40%), and two with MAT (50%) showed other accompanying clinical abnormalities. In all patients who were studied histologically, changes in the myocardium were seen; myocarditic changes, postmyocarditic changes and nonspecific abnormalities were present in six (12%). 15 (30%), and nine (18%) respectively. Myocardial changes were observed in four out of seven cases with AVNRT (57%), in six out of nine with AVR‐CBT (67%), in five out of 13 with manifest WPW (38%), in two out of three with SNRT or IART (67%), in six out of nine with AF (67%), in all five cases of AAT (100%), and in two out of four with MAT (50%). Nineteen out of 32 without clinical abnormalities except for arrhythmias (59%) had myocardial changes (six had myocarditic changes, ten had postmyocarditic changes, and three had nonspecific abnormalities). On the other hand, nine out of 21 with myocarditic or postmyocarditic changes were accompanied with various arrhythmias other than SVT (two had SSS, five had AV block or rBBB, and two had VT). Elevated LVEDP was present in 36% of the group with normal myocardium and in 53% of the group with myocardial changes. However, the low EF was shown in no patients with normal myocardium but in 21% of the group with myocardial changes. The low CI was also shown in only 9% of the group with normal myocardium but in 28% of the group with myocardial changes. These results suggest that patients with SVT may exhibit several histopathological changes in the myocardium, even in the absence of any clinical organic heart disease.
Sex assessment efficacy of permanent maxillary first molar cusp dimensions in Indians

Background: The human first maxillary molar provides clues about evolution and is functionally important. It has four main cusps, and each cusp has an independent growth pattern and different evolutionary background. Though less explored, the analysis based on measurement of each cusp appears to be more meaningful biologically than conventional measurements of the whole crown. Aim: This study aimed to demonstrate the extent of sexual dimorphism in permanent maxillary first molar cusp diameters and their potential utility in sex prediction among Indians using logistic regression analysis (LRA). Materials and Methods: The mesiodistal and buccolingual (BL) crown diameters along with cusp dimensions and cusp indices of right maxillary first molar were measured in an Indian sample (149 males, 151 females; age range of 18–30 years). The possible sex dimorphism in these parameters was evaluated, and LRA was performed to ascertain their usefulness in sex prediction. Results: BL crown dimension and the hypocone (distolingual) cusp showed the highest sexual dimorphism. The combination of metacone and hypocone, i.e., distal cusp diameters among cusp parameters showed the highest accuracy (61.3%). While, on combining all the crown and cusp diameters together the overall accuracy was raised (64.3%). Conclusion: This study supports the ontogeny hypothesis suggesting that early-forming mesial cusps demonstrate less sexual variation as compared to subsequently formed distal cusps in the maxillary molar. Though the sex identification accuracy for cusp diameters of the permanent maxillary first molar in Indians is relatively moderate (≈61%), it can be used as an adjunct for sexing of adult Indians in forensic contexts.
The Imbalance of B-Lymphocyte Subsets in Subjects with Different Glucose Tolerance: Relationship with Metabolic Parameter and Disease Status

B lymphocytes are involved in inflammation and are related to insulin resistance in obesity and type 2 diabetes (T2D). This study investigated the phenotype and frequency of B-lymphocyte subsets in subjects recently diagnosed with T2D (n = 60), impaired glucose regulation (IGR, n = 73), and normal glucose tolerance (NGT, n = 169) by flow cytometry. T2D subjects had an increased percentage of CD19+CD23+ (B-2) cells and a decreased percentage of CD19+CD23− (B-1) cells attributing to CD19+CD23−CD5− (B-1b) cells, but not CD19+CD23−CD5+ (B-1a) cells, compared to NGT and IGR subjects. The proportion of CD19+CD5+CD1dhi (B10) cells did not differ between the IGR or T2D group and NGT controls. Of note, HbA1c and triglyceride showed a positive correlation with B-2 cells but an inverse correlation with B-1 and B-1b cells, which were independently associated with the presence of T2D by logistic regression models. In summary, this study shows an unbalanced proinflammatory phenotype of B-cell subsets correlated with glycemia and lipidemia in patients with T2D. Our data provide new insight into chronic activation of the immune system and subclinical inflammation in T2D. Further prospective studies are warranted to confirm our observations.
The development of earnings management research

Earnings management directly affects the overall integrity of financial reporting and significantly influences resource allocation in an economy. The objective of this paper is to help academic researchers, regulators, and investors better understand issues surrounding earnings management. We review the research on earnings management from early 1960s to date. We particularly discuss the changes of different research focus in each stage of the development of earnings management research and the economic consequences of earnings management which directly affect capital resource allocation.
The McLean-Harvard First-Episode Mania Study: prediction of recovery and first recurrence.

OBJECTIVE Since improved prediction of illness course early in bipolar disorder is required to guide treatment planning, the authors evaluated recovery, first recurrence, and new illness onset following first hospitalization for mania. METHOD Bipolar disorder patients (N=166) were followed 2-4 years after their first hospitalization for a manic or mixed episode to assess timing and predictors of outcomes. Three aspects of recovery were measured: syndromal (DSM-IV criteria for disorder no longer met), symptomatic (Young Mania Rating Scale score </=5 and Hamilton Depression Rating Scale score </=8), and functional (regaining of premorbid occupational and residential status). Rates of remission (syndromal recovery sustained >/=8 weeks), switching (onset of new dissimilar illness before recovery), relapse (new episode of mania within 8 weeks of syndromal recovery), and recurrence (new episode postremission) were also assessed. RESULTS By 2 years, most subjects achieved syndromal recovery (98%, with 50% achieving recovery by 5.4 weeks); 72% achieved symptomatic recovery. Factors associated with a shorter time to syndromal recovery for 50% of the subjects were female sex, shorter index hospitalization, and lower initial depression ratings. Only 43% achieved functional recovery; these subjects were more often older and had shorter index hospitalizations. Within 2 years of syndromal recovery, 40% experienced a new episode of mania (20%) or depression (20%), and 19% switched phases without recovery. Predictors of mania recurrence were initial mood-congruent psychosis, lower premorbid occupational status, and initial manic presentation. Predictors of depression onset were higher occupational status, initial mixed presentation, and any comorbidity. Antidepressant treatment was marginally related to longer time to recovery and earlier relapse. CONCLUSIONS Within 2-4 years of first lifetime hospitalization for mania, all but 2% of patients experienced syndromal recovery, but 28% remained symptomatic, only 43% achieved functional recovery, and 57% switched or had new illness episodes. Risks of new manic and depressive episodes were similar but were predicted by contrasting factors.
Oxidative Stress and Genotoxicity in Pterygium: A Systemic Investigation.

OBJECTIVES To perform a systemic investigation on oxidative stress and DNA damage in patients with primary pterygium. METHODS This prospective cross-sectional study included 32 patients with primary pterygium (60.1±2.0 years of age) and 33 age- and sex-matched (58.8±2.2 years of age) control subjects (P>0.05). A commercial kit was used for measuring serum total oxidant status (TOS) and total antioxidant status (TAS). The comet assay was performed after lymphocyte isolation from venous blood to quantitate DNA damage. Tail length (TL), tail intensity (TI), and tail moment (TM) were used for statistical analysis as parameters of DNA damage. RESULTS In the pterygium group, TOS and TAS were significantly higher when compared with those of the control group (P=0.019 and P=0.005, respectively). In terms of DNA damage, patients with pterygium had higher TL, TI, and TM than in the control subjects (P<0.0001 for all). CONCLUSIONS Although current literature focuses on local factors in pterygium pathogenesis, patients with pterygium seem to have increased systemic oxidative status (and compensatory antioxidant response) and genotoxicity, which might create a predisposition for pterygium development.
Visualization of Hyperspectral Images Using Moving Least Squares

Displaying the large number of bands in a hyperspectral image (HSI) on a trichromatic monitor has been an active research topic. The visualized image shall convey as much information as possible from the original data and facilitate image interpretation. Most existing methods display HSIs in false colors, which contradict with human's experience and expectation. In this paper, we propose a nonlinear approach to visualize an input HSI with natural colors by taking advantage of a corresponding RGB image. Our approach is based on Moving Least Squares (MLS), an interpolation scheme for reconstructing a surface from a set of control points, which in our case is a set of matching pixels between the HSI and the corresponding RGB image. Based on MLS, the proposed method solves for each spectral signature a unique transformation so that the nonlinear structure of the HSI can be preserved. The matching pixels between a pair of HSI and RGB image can be reused to display other HSIs captured by the same imaging sensor with natural colors. Experiments show that the output images of the proposed method not only have natural colors but also maintain the visual information necessary for human analysis.
Systematic Internal Transcribed Spacer Sequence Analysis for Identification of Clinical Mold Isolates in Diagnostic Mycology: a 5-Year Study

ABSTRACT The implementation of internal transcribed spacer (ITS) sequencing for routine identification of molds in the diagnostic mycology laboratory was analyzed in a 5-year study. All mold isolates (n = 6,900) recovered in our laboratory from 2005 to 2009 were included in this study. According to a defined work flow, which in addition to troublesome phenotypic identification takes clinical relevance into account, 233 isolates were subjected to ITS sequence analysis. Sequencing resulted in successful identification for 78.6% of the analyzed isolates (57.1% at species level, 21.5% at genus level). In comparison, extended in-depth phenotypic characterization of the isolates subjected to sequencing achieved taxonomic assignment for 47.6% of these, with a mere 13.3% at species level. Optimization of DNA extraction further improved the efficacy of molecular identification. This study is the first of its kind to testify to the systematic implementation of sequence-based identification procedures in the routine workup of mold isolates in the diagnostic mycology laboratory.
Relationship between antioxidant capacity and oxidative stress in children with acute hepatitis A.

AIM To investigate in children with acute hepatitis A. According to our knowledge, there are no data about the blood levels of malondialdehyde (MDA, an indicator of oxidative stress) and nonenzymic antioxidants in children with acute hepatitis A. METHODS Whole blood MDA and reduced glutathione (GSH), serum beta-carotene, retinol, vitamin E and vitamin C levels were studied in 19 (10 females, 9 males) children with acute hepatitis A and in 29 (13 females, 16 males) healthy control subjects. RESULTS There was a statistically significant difference between patients and controls for all parameters (P < 0.05). Lipid peroxidation marker MDA was significantly elevated (P < 0.001), while antioxidants beta-carotene, retinol and GSH were significantly decreased (all P < 0.001) in patients compared to healthy subjects. In addition, alpha-tocopherol and ascorbic acid levels were significantly lower in patients when compared to age and sex matched controls (P < 0.05, P < 0.01, respectively). CONCLUSION Our study shows that hepatitis A virus induces oxidative stress in children with hepatitis A. This finding could be taken into consideration to improve the therapeutic approach in acute hepatitis A.
Improved Attribution of Climate Forcing to Emissions

All Together Now Deciding how to change emissions of polluting gases that affect climate through their radiative forcing properties requires that the quantitative impact of these emissions be understood. Most past calculations of this type have considered only the radiative forcing of the specific emission and its atmospheric lifetime. Shindell et al. (p. 716; see the Perspectives by Arneth et al. and by Parrish and Zhu) use sophisticated atmospheric chemical and climate modeling to determine how gas-aerosol interactions affect the radiative properties of the atmosphere, finding significant departures from the standard method for emissions of methane, carbon monoxide, and nitrogen oxides. These findings should help to optimize strategies for mitigating global warming by reducing anthropogenic emissions. Chemical interactions between atmospheric gases and aerosols modify the global warming impacts of emissions. Evaluating multicomponent climate change mitigation strategies requires knowledge of the diverse direct and indirect effects of emissions. Methane, ozone, and aerosols are linked through atmospheric chemistry so that emissions of a single pollutant can affect several species. We calculated atmospheric composition changes, historical radiative forcing, and forcing per unit of emission due to aerosol and tropospheric ozone precursor emissions in a coupled composition-climate model. We found that gas-aerosol interactions substantially alter the relative importance of the various emissions. In particular, methane emissions have a larger impact than that used in current carbon-trading schemes or in the Kyoto Protocol. Thus, assessments of multigas mitigation policies, as well as any separate efforts to mitigate warming from short-lived pollutants, should include gas-aerosol interactions.
Feather papilla stimulation by progesterone.

Radio Observations of Meteors: P. M. Millman 35. 325 i ~~~~~~~~~~~~~~~~~~~A New Crystalline Silica: P. P. Keat . 328 News and Notes Soil Microbiology; Friends of the Pleistocene; and Regular Departments 331 Book Reviews Infrared Absorption Spectra of Steroids; Collected Papers of Stephen P. Timoshenko; Die Welt der ungewohnten Dimensionen; Progress in Nuclear Physics; Progress in Cosmic Ray Physics; Flow Properties of Disperse Systems; Modulation Theory; Physics for Medical Students; Inorganic Syntheses; Bailey's Text-Book of Histology; Synthesis and Metabolism of Adrenocortical Steroids; and Miscellaneous Publications 339
Role of immunohistochemical cyclo-oxygenase-2 (COX-2) and osteocalcin in differentiating between osteoblastomas and osteosarcomas.

BACKGROUND/AIMS Differential diagnosis between aggressive osteoblastoma and low grade osteosarcoma may be very difficult or even impossible on a small biopsy. This study was designed to assess the usefulness of immunoexpression of COX-2 and osteocalcin in the differential diagnosis of the two tumour types. METHODS Immunostaining of COX 2 and osteocalcin were studied in 9 osteoblastomas and 30 osteosarcomas. RESULTS All osteoblastomas and 11/20 (55%) high-grade osteosarcomas showed COX-2 immunoreactivity. All low grade osteosarcomas were COX-2 negative. COX-2 was significantly higher (p<0.002) in osteoblastomas 9/9 (100%) than in osteosarcomas 13/30 (43%) and in aggressive osteoblastomas versus low grade osteosarcomas (p<0.01). Osteocalcin was found in tumour cells of all osteosarcomas and osteoblastomas and in the osteoid matrix of 84% of osteosarcomas and 78% of osteoblastomas. Strong osteocalcin was significantly higher (p<0.02) in osteoblastomas (78%) than in osteosarcomas (27%). CONCLUSION COX-2 is a valuable marker in distinction between osteosarcoma and osteoblastoma. Negative COX-2 could confirm the diagnosis of low grade osteosarcoma versus aggressive osteoblastoma. Intensity and distribution of osteocalcin may indicate the degree of osteoblastic differentiation.
Linköping University Post Print Color Emotions for Image Classification and Retrieval

Abstract Many content-based image retrieval systems are not tak-ing into account high level semantic information. In this paperwe describe our attempts to include color-based emotion-relatedproperties of images in the search. We show that using coloremotion metrics in content-based image retrieval leads to inter-esting methods for image retrieval and classiﬁcation based onsemantic concepts. The color emotion metric used is derivedfrom psychophysical experiments and uses three scales: activ-ity, weight and heat. It was originally designed for single-colorcombinations and later extended to include pairs of colors. Weshow that a modiﬁed approach for statistical analysis of coloremotions in images, involving transformations of ordinary RGB-histograms, provides a useful tool for image classiﬁcation andretrieval. The methods used are both very fast in feature extrac-tion, and descriptor vectors are very short. This is essential inour application where we intend to use it for searching huge im-age databases containing millions or billions of images.
Mice Bearing MDA-MB-361 Human Breast Cancer Xenografts Downregulation and Tumor Response in Athymic HER 2 Trastuzumab-Mediated In-DTPA-Pertuzumab Sensitively Detects 111 Micro-SPECT / CT with

Published online: July 17, 2009. 2009;50:1340-1348. J Nucl Med. Raymond M. Reilly Kristin McLarty, Bart Cornelissen, Zhongli Cai, Deborah A. Scollard, Danny L. Costantini, Susan J. Done and Mice Bearing MDA-MB-361 Human Breast Cancer Xenografts Downregulation and Tumor Response in Athymic HER2 Trastuzumab-Mediated In-DTPA-Pertuzumab Sensitively Detects 111 Micro-SPECT/CT with http://jnm.snmjournals. org/content/50/8/1340 This article and updated information are available at: http://jnm.snmjournals. org/site/subscriptions/online.xhtml Information about subscriptions to JNM can be found at: http://jnm.snmjournals. org/site/misc/permission.xhtml Information about reproducing figures, tables, or other portions of this article can be found online at:
Immunohistochemical expression of P15 (INK4B) and SMAD4 in advanced gastric cancer.

BACKGROUND P15 (a cyclin- D- kinase inhibitor) and SMAD4 (a signal transducer of the TGF-beta pathway) are two closely related proteins which may have an important role in gastric carcinogenesis. MATERIALS AND METHODS Sixty-three gastric carcinomas were studied. P15 and SMAD4 immunohistochemical expression was assessed with the DCS114.1 and BC/B8 mouse monoclonal antibodies, respectively. The results were tested for correlation with several clinicopathological parameters and patient survival. RESULTS Fifteen out of the 18 (83%) P15-positive tumors also exhibited preserved SMAD4 positivity (p = 0.001). Loss of P15 expression was more frequent in the intestinal type of carcinoma (p = 0.047). The survival rates were significantly higher for patients with reduced SMAD4 expression, in cases of well- or moderately differentiated tumors (p = 0.042). CONCLUSION P15 gene silencing might be an important event in the tumorigenesis of gastric adenocarcinomas of the intestinal type. Smad4 may behave as a tumor promoter in low grade tumors. The observed association between P15 and SMAD4 expression supports the inductive role of Smad4 in p15 transcription.
Age related differences in humoral immune response to respiratory syncytial virus infection in adults

The humoral immune response to Respiratory Syncytial Virus (RSV) was investigated in old and young adults. RSV was identified by culture and/or reverse transcription polymerase chain reaction (RT‐PCR) in 52 elderly (mean age 74 years) and 15 young adults (mean age 33 years) with respiratory illness. Preinfection serum neutralizing and binding antibody levels were similar in the two age groups, although older persons had significantly greater serum neutralizing responses to group A RSV (log2 2.8 increase vs. 1.7, P = 0.001) and group B RSV (log2 2.8 vs. 1.3, P = 0.0008). Older persons also had significantly increased responses to the RSV F (log2 2.9 vs. 1.1, P < 0.0001), Ga (log2 2.1 vs. 1.3, P = 0.0007), and Gb proteins (log2 2.7 vs. 1.4, P = 0.0004). The exuberant antibody response seen in older adults may be a reflection of greater viral load and antigenic stimulation and/or a shift from Th1 to Th2 dominant immune response with aging. The relationship of immune response to disease pathogenesis in older persons deserves further study. J. Med. Virol. 73:295–299, 2004. © 2004 Wiley‐Liss, Inc.
Neurotrophin‐3 prevents death of axotomized Clarke's nucleus neurons in adult rat

In the present investigation, we studied whether neurotrophin‐3 (NT‐3) contributes to the rescue of axotomized Clarke's nucleus (CN) neurons in adult rats. A significant (24%) loss of CN neurons occurred at L‐1 ipsilateral to T‐8 hemisection by 14 days, which reached 31% at 2 months and then stabilized. Axotomized CN neurons had also atrophied by 14 days, but mean cell size did not decrease further. Animals that received gelfoam soaked in nerve growth factor, brain derived neurotrophic factor, or ciliary neurotrophic factor at the lesion site also showed a 30% neuron loss at 2 months, and a 40% reduction in average cell area. Rats receiving NT‐3 showed a 15% neuron loss, which was not improved by additional neurotrophins in combination with NT‐3. None of the treatments prevented neuron atrophy. Bioassay of the gelfoam showed that NT‐3 bioactivity remained at 5 days after surgery but not at 14 days. Additional rats with hemisections that received NT‐3 continuously via mini‐pump for 2 months showed a 15% neuron loss, the same as with NT‐3 given via gelfoam.