Miracle-dz/UniFAR-FTUs huggingface dataset:
Crystalline methamphetamine use and methamphetamine‐related harms in Australia

INTRODUCTION AND AIMS Concerns about crystal methamphetamine use and harm have increased in multiple countries. This paper describes how changes in the availability and use of crystal methamphetamine have impacted on methamphetamine-related harms in Australia. DESIGN AND METHODS Data on methamphetamine use were obtained from population-level surveys, health service data and surveys of drug use among sentinel groups of ecstasy users and people who inject drugs. Data were obtained on seizures, arrests, clandestine laboratory detections, hospital separations, mental health unit admissions, drug telephone helpline calls and drug treatment episodes. Segmented linear regression models were fitted to identify changes in these series using log-transformed data where appropriate. RESULTS The availability of crystal methamphetamine has increased as evidenced by increased laboratory detections, domestic seizures and purity of the seized drug. Population surveys do not report an increase in the number of people who used at least once in the past year. However, more users report using crystal methamphetamine rather than lower-purity powder methamphetamine and more regular use. Indicators of methamphetamine-related harms have increased in parallel with this change. Amphetamine-related helpline calls, drug treatment, arrests and hospital admissions for amphetamine disorders and psychosis all peaked in the mid-2000s, declined for several years and have increased steeply since 2010. DISCUSSION AND CONCLUSIONS The increased availability and use of crystal methamphetamine have been associated with increased regular use and harms. Treatment is required for those experiencing problems and the capacity of health services to provide care needs to be enhanced. [Degenhardt L, Sara G, Connor JP, McKetin R, Roxburgh A, Dobbins T, Farrell M, Burns L, Hall WD. Crystalline methamphetamine use and methamphetamine-related harms in Australia. Drug Alcohol Rev 2017;36:160-170].
Yellow (577 nm) micropulse laser versus half-dose verteporfin photodynamic therapy in eyes with chronic central serous chorioretinopathy: results of the Pan-American Collaborative Retina Study (PACORES) Group

Purpose To compare the functional and anatomical outcomes of eyes with chronic central serous chorioretinopathy treated with yellow micropulse (MP) laser versus half-dose verteporfin photodynamic therapy (PDT). Methods This is a multicentre, retrospective comparative study of 92 eyes treated with yellow MP laser (duty cycle of 5%, zero spacing between spots, spot size varied from 100 to 200 µm, power varied from 320 to 660 mW, and the pulse burst duration was 200 ms) and 67 eyes treated with PDT (half-dose verteporfin (3 mg/m2) infused over 10 min), followed by laser activation for 83 s. Spot sizes varied from 400 to 2000 µm. Results In the MP group, at 12 months of follow-up, the mean best corrected visual acuity (BCVA) improved from the logarithm of the minimum angle of resolution (logMAR) of 0.41±0.27 at baseline to 0.21±0.26 (P<0.0001), 48.9% (45/92) of eyes had an improvement of ≥3 lines of BCVA from baseline, 48.9% (45/92) of eyes remained within 2 lines of baseline BCVA, and only 2.2% (2/92) of eyes lost ≥3 lines of BCVA from baseline. In the PDT group, at 12 months of follow-up, the mean BCVA changed from logMAR of 0.50±0.34 at baseline to 0.47±0.34 (P=0.89), 19% (13/67) of eyes had an improvement of ≥3 lines of BCVA from baseline, 73% (49/67) of eyes remained within 2 lines of baseline BCVA, and 7% (5/67) of eyes lost ≥3 lines of BCVA from baseline. There were no adverse events attributable to the yellow MP laser treatment. One eye in the PDT group developed choroidal neovascularisation, which was treated with three intravitreal bevacizumab injections. Conclusions Both PDT and MP are effective in restoring the macular anatomy. In places where PDT is not available, yellow MP laser may be an adequate treatment alternative.
Risk-based strategies: the social responsibility of investment universes does matter

In this article we extend the research on risk-based asset allocation strategies by exploring how using an SRI universe modifies properties of risk-based portfolios. We focus on four risk-based asset allocation strategies: the equally weighted, the most diversified portfolio, the minimum variance and the equal risk contribution. Using different estimators of the matrix of covariances, we apply these strategies to the EuroStoxx universe of stocks, the Advanced Sustainability Performance Index (ASPI) and the complement of the ASPI in the EuroStoxx universe from March 15, 2002 to May 1, 2012. We observe several impacts but one is particularly important in our mind. We observe that risk-based asset allocation strategies built on the entire universe, concentrate their solution on non-SRI stocks. Such risk-based portfolios are therefore under-weighted in socially responsible firms.
Pharmacological Rescue of Conditionally Reprogrammed Cystic Fibrosis Bronchial Epithelial Cells

&NA; Well‐differentiated primary human bronchial epithelial (HBE) cell cultures are vital for cystic fibrosis (CF) research, particularly for the development of cystic fibrosis transmembrane conductance regulator (CFTR) modulator drugs. Culturing of epithelial cells with irradiated 3T3 fibroblast feeder cells plus the RhoA kinase inhibitor Y‐27632 (Y), termed conditionally reprogrammed cell (CRC) technology, enhances cell growth and lifespan while preserving cell‐of‐origin functionality. We initially determined the electrophysiological and morphological characteristics of conventional versus CRC‐expanded non‐CF HBE cells. On the basis of these findings, we then created six CF cell CRC populations, three from sequentially obtained CF lungs and three from F508 del homozygous donors previously obtained and cryopreserved using conventional culture methods. Growth curves were plotted, and cells were subcultured, without irradiated feeders plus Y, into air‐liquid interface conditions in nonproprietary and proprietary Ultroser G‐containing media and were allowed to differentiate. Ussing chamber studies were performed after treatment of F508 del homozygous CF cells with the CFTR modulator VX‐809. Bronchial epithelial cells grew exponentially in feeders plus Y, dramatically surpassing the numbers of conventionally grown cells. Passage 5 and 10 CRC HBE cells formed confluent mucociliary air‐liquid interface cultures. There were differences in cell morphology and current magnitude as a function of extended passage, but the effect of VX‐809 in increasing CFTR function was significant in CRC‐expanded F508 del HBE cells. Thus, CRC technology expands the supply of functional primary CF HBE cells for testing CFTR modulators in Ussing chambers.
Diffusion-weighted Imaging Is a Sensitive and Specific Magnetic Resonance Sequence in the Diagnosis of Ankylosing Spondylitis

Objective. We tested the discriminatory capacity of diffusion-weighted magnetic resonance imaging (DWI) and its potential as an objective measure of treatment response to tumor necrosis factor inhibition in ankylosing spondylitis (AS). Methods. Three cohorts were studied prospectively: (1) 18 AS patients with Bath Ankylosing Spondylitis Disease Activity Index > 4, and erythrocyte sedimentation rate > 25 and/or C-reactive protein > 10 meeting the modified New York criteria for AS; (2) 20 cases of nonradiographic axial spondyloarthritis (nr-axSpA) as defined by the Assessment of Spondyloarthritis international Society (ASAS) criteria; and (3) 20 non-AS patients with chronic low back pain, aged between 18 and 45 years, who did not meet the imaging arm of the ASAS criteria for axSpA. Group 1 patients were studied prior to and following adalimumab treatment. Patients were assessed by DWI and conventional magnetic resonance imaging (MRI), and standard nonimaging measures. Results. At baseline, in contrast to standard nonimaging measures, DWI apparent diffusion coefficient (ADC) values showed good discriminatory performance [area under the curve (AUC) > 80% for Group 1 or 2 compared with Group 3]. DWI ADC values were significantly lower posttreatment (0.45 ± 0.433 before, 0.154 ± 0.23 after, p = 0.0017), but had modest discriminating capacity comparing pre– and posttreatment measures (AUC = 68%). This performance was similar to the manual Spondyloarthritis Research Consortium of Canada (SPARCC) scoring system. Conclusion. DWI is informative for diagnosis of AS and nr-axSpA, and has moderate utility in assessment of disease activity or treatment response, with performance similar to that of the SPARCC MRI score.
Later-Life Preparation Patterns on Depression Among Korean Baby Boom Generations

The aim of this study was to examine the later-life preparation pattern of Korean baby boomers and its effect on depression. Using the fourth wave of Korean Retirement and Income Study, later-life preparation was measured by economic, physical, and psychological preparation, and leisure, and family relationship satisfaction. The data analysis included latent class analysis, correlations, multiple logistic regression, and analysis of variance. Later-life patterns of Korean baby boomers were classified as high-level (35.7%), low-level (31.1%), and health and family relationship (33.2%) preparation patterns. For depression, the low-level pattern was associated with significantly higher level of depression; however, no differences were found in other two patterns. Researchers recommended a postretirement program to reflect the unique characteristics of Korean baby boomers. Moreover, findings regarding the importance of health and family relationships can be applied to other countries that have historical and cultural backgrounds similar to Korea.
Can We Trust the Use of Smartphone Cameras in Clinical Practice? Laypeople Assessment of Their Image Quality.

BACKGROUND Smartphone cameras are rapidly being introduced in medical practice, among other devices for image-based teleconsultation. Little is known, however, about the actual quality of the images taken, which is the object of this study. MATERIALS AND METHODS A series of nonclinical objects (from three broad categories) were photographed by a professional photographer using three smartphones (iPhone(®) 4 [Apple, Cupertino, CA], Samsung [Suwon, Korea] Galaxy S2, and BlackBerry(®) 9800 [BlackBerry Ltd., Waterloo, ON, Canada]) and a digital camera (Canon [Tokyo, Japan] Mark II). In a Web survey a convenience sample of 60 laypeople "blind" to the types of camera assessed the quality of the photographs, individually and best overall. We then measured how each camera scored by object category and as a whole and whether a camera ranked best using a Mann-Whitney U test for 2×2 comparisons. RESULTS There were wide variations between and within categories in the quality assessments for all four cameras. The iPhone had the highest proportion of images individually evaluated as good, and it also ranked best for more objects compared with other cameras, including the digital one. The ratings of the Samsung or the BlackBerry smartphone did not significantly differ from those of the digital camera. CONCLUSIONS Whereas one smartphone camera ranked best more often, all three smartphones obtained results at least as good as those of the digital camera. Smartphone cameras can be a substitute for digital cameras for the purposes of medical teleconsulation.
DYNAMICS OF CONJUNCTIVITIS AND MYCOPLASMA GALLISEPTICUM INFECTIONS IN HOUSE FINCHES

Abstract Conjunctivitis, an infectious disease caused by Mycoplasma gallisepticum (MG), has produced a significant decline in eastern House Finches (Carpodacus mexicanus) of North America. In this paper, we present findings from two complementary studies designed to clarify annual and seasonal trends of MG infections in House Finches from the northeastern United States. The first was a field study of House Finches common to urban and residential habitat from Mercer County, New Jersey. We documented conjunctivitis in 11% (188/1,651) of the birds examined. Conjunctivitis prevalence in House Finches ranged from 0 to 43% per month, and exhibited marked seasonal fluctuation (elevations during fall and winter months and lower disease prevalence during the breeding season). There was excellent intermethod agreement on disease prevalence when measured by either presence of physical signs (conjunctivitis) or MG infection (kappa = 0.75). During the peak of the breeding season (April through June), conjunctivitis was present in a greater proportion of males lacking a cloacal protuberance than males with a cloacal protuberance (P < 0.01), but was similar between breeding and nonbreeding females. The second study, a volunteer survey, revealed the proportion of northeastern U.S. monitoring sites with at least one diseased House Finch each month ranged from a peak of 59% (August 1995) to a minimum of 12% (July 1999). Subsequent to the epidemic peak of disease in 1995, a series of recurring cycles occurred, with elevations in those proportions noted in late fall and winter and minima during the breeding season. Mycoplasmal conjunctivitis now appears endemic among House Finches of that region and demonstrates dynamics consistent with annual variation in host density.
Association of Neighborhood Design and Recreation Environment Variables with Physical Activity and Body Mass Index in Adolescents

Purpose. To examine associations of neighborhood walkability and recreation environment variables with physical activity in adolescents. Methods. The cross-sectional study was conducted with 98 white or Mexican-American adolescents (mean age = 16.2 years). Physical activity was measured with 7 days of accelerometer monitoring. Height and weight were measured to compute body mass index (BMI). Environmental measures were created using geographic information systems. A neighborhood walkability index was based on land use mix, retail density, street connectivity, and residential density. Proximity to public and private recreation facilities was assessed. Results. In a linear regression, the walkability index within 0.5 mile of homes was related to minutes of moderate to vigorous physical activity, explaining approximately 4% of variance. Recreation variables were not related to physical activity, and BMI was not explained by environmental variables. Conclusion. Neighborhood walkability was related to adolescents' physical activity, similar to findings for adults.
Zika clinical updates: implications for pediatrics

Purpose of review Zika virus (ZIKV), a mosquito-borne flavivirus, has gained recognition over the past few years as an important new cause of congenital infection. As a result, it is critical that pediatricians understand its epidemiology, clinical presentation, clinical sequelae, and management. Recent findings The recent ZIKV epidemiology, clinical presentation of acute infection in children and complications, perinatal infection, and congenital infection will be summarized in this ZIKV review. This will be followed by a brief summary on ZIKV diagnosis, management, treatment, and prevention. Summary The field of clinical research in ZIKV has rapidly evolved over recent months. It is critical that pediatricians continue to stay up-to-date with the continuously evolving understanding of the clinical aspects of ZIKV to ensure optimal identification and management of affected infants and children. Given the recent changes in Centers for Disease Control and Prevention guidelines to limit screening of asymptomatic pregnant women in the United States with possible ZIKV exposure, comprehensive ZIKV clinical knowledge becomes even more crucial.
Correlated electron probe microanalysis and microradiography of carious and normal dental cementum.

In order to compare the distribution of elements in carious cementum and root dentin with the morphology of the lesion, a correlated electron probe microanalysis and microradiographic study was carried out. Ground sections of human teeth showing early stages of root suface caries were microradiographed and subsequently analyzed for the presence of Ca, P, F, S, Mg, Na, Fe, Cu, Zn Sn, and Ag. The results show that caries in cementum starts as a partial decalcification which soon reaches the peripheral dentin and may extend to a depth of a third of a millimeter without any loos of surface contour at the light microscopic level of observation. The pattern of dissolution and reprecipitation of mineral components seems to follow the pattern seen in dentin caries. Although reprecipitation of mineral forming a hypercalcified layer at the surface of the lesion occurs regularly, a surface layer of increased radiopacity may be found even in the absence of this process due to the adsorption of foreign, heavy elements in the surface layer of carious cementum. The relatively high F content normally found in the outer layer and the additional accumulation of F in this layer both from saliva and incident to the outward diffusion of dissolved mineral, result in the development of a particularly distinct zone of recalcification at the surface during the early stages of cementum caries.
Outage-Based Admission Control for Multi-User MISO Transmission with Imperfect CSIT

We consider downlink multi-input single-output transmission in multi-cell mobile wireless networks. We consider a finite-scatterer directional channel model with imperfect channel state information at the transmitter. Specifically, we assume imperfect knowledge of the signal angles of departure of the scattering components, as well as uncertainty about the relative phase-shifts between the signals arriving over these scattering multipath components. For this situation we determine the outage probability of linear beamforming at the transmitters and utilize the results for multi-user scheduling and admission control. The considered channel model relates to Rician fading and to two wave with diffuse power fading for the special cases of a single specular component and two specular components, respectively.
Collateral circulation between angiosomes in the feet of diabetic patients

Objectives The main factor in the healing of foot ulcers in diabetic patients is adequate perfusion. There is no consensus on whether direct or indirect revascularization is more effective in leg revascularization. At the centre of that debate, there is a disagreement about whether collateral circulation is sufficient or not. Our aim is to evaluate collateral circulation activity between angiosomes in the feet of diabetic patients by evaluating the level of occlusion in leg arteries and comparing the angiosome regions that have necrosis. Methods The study included 61 patients. All had undergone CT angiography to the lower extremity prior to any revascularization of the leg arteries between September 2014 and September 2016. Stenosis was evaluated on the anterior tibial artery, the posterior tibial artery and the peroneal artery up to the level of the ankle. The opening of the vessel wall at the narrowest part of the vessel was determined as a percentage. The areas with necrosis were determined according to the angiosomes of the posterior tibial artery, anterior tibial artery and peroneal artery vessels. Results Necrosis of the foot was most common in the posterior tibial artery angiosome. Necrosis in the posterior tibial artery angiosome was independent of the level of posterior tibial artery occlusion; however, it was associated with the occlusion of the anterior tibial artery (p < 0.05). It was found that anterior tibial artery occlusion over 15% resulted in necrosis in the posterior tibial artery angiosome. Conclusions Collateral circulation between the anterior tibial artery and posterior tibial artery is active and there is almost always occlusion in the posterior tibial artery branches. The posterior tibial artery angiosome is fed by the collateral arteries of the anterior tibial artery even if there is no occlusion of posterior tibial artery at the level of the leg, so indirect revascularization on the anterior tibial artery is sufficient to provide foot circulation.
Clinical and molecular features of innate and acquired resistance to anti-PD-1/PD-L1 therapy in lung cancer

Hypothesis The majority of non-small cell lung cancer (NSCLC) patients treated with anti-PD-1/PD-L1 therapy develop either innate or acquired resistance. Across tumor types, the “T cell-inflamed” tumor microenvironment correlates with clinical response to immunotherapy. We hypothesize that clinical characteristics may be predictive of resistance and that “T cell-inflamed” NSCLC tumors can be identified by gene expression profiling. Results Of 93 patients, 36 (38.7%) had innate resistance and 57 (61.3%) had initial benefit to immunotherapy. Innate resistance was associated with non-smokers (p = 0.013), more involved disease sites (p = 0.011), more prior therapy (p = 0.001), and a lower albumin level (p = 0.014). Among patients with initial benefit, factors associated with subsequent progression-free survival included higher Karnofsky Performance Status (KPS) (p = 0.004) and lower depth of response to anti-PD-1 therapy (p = 0.003). A “T cell-inflamed” microenvironment was identified in 42% of TCGA adenocarcinoma samples versus 21.0% of squamous cell. Discussion Specific clinical characteristics appear to be predictive of either innate or acquired resistance to anti-PD-1/PD-L1 therapy. A “T cell-inflamed” tumor was more common in adenocarcinoma than squamous histology. Methods A retrospective review of NSCLC patients treated with anti-PD-1/PD-L1 monotherapy. Patients with innate resistance to anti-PD-1/PD-L1 therapy (defined as progression at first CT evaluation) were compared to patients with initial clinical benefit. Among those with initial clinical benefit, we identified prognostic factors for time to progression (acquired resistance) or death. To further corroborate our findings on limited numbers, immune gene expression profiling of all NSCLC samples from the TCGA database was also pursued.
Carbohydrate-Mediated Formation of the Oviductal Sperm Reservoir in Mammals

Mammalian sperm are trapped in a reservoir in the oviduct until ovulation is imminent. Then, they are gradually released, such that a few meet the oocytes as they enter the ampulla of the oviduct. In the three eutherian species studied to date, sperm are trapped in the reservoir by carbohydrate-mediated binding to the oviductal mucosa. Evidence indicates that a molecule on the surface of the plasma membrane overlying the acrosome binds to a carbohydrate moiety on the surface of the oviduct. While sperm remain bound, they appear to be protected from degradation. When sperm become capacitated, they lose binding affinity for the oviductal mucosa. The mechanism initiating capacitation in the reservoir is unknown; however, it must be tied to the hormonal signalling of ovulation. Hyperactivated motility may assist sperm in pulling off from the mucosal surface as binding affinity declines. The function of the reservoir appears to be to prevent polyspermy and ensure fertilization by providing a small number of sperm in the proper physiological condition for fertilization at the time the oocytes enter the oviduct.