Miracle-dz/UniFAR-FTUs huggingface dataset:
Self-Paced Team-Sport Match Simulation Results in Reductions in Voluntary Activation and Modifications to Biological, Perceptual, and Performance Measures at Halftime and for up to 96 Hours Postmatch

Abstract Tofari, PJ, Kemp, JG, and Cormack, SJ. Self-paced team-sport match-simulation results in reductions in voluntary activation and modifications to biological, perceptual, and performance measures at halftime and for up to 96 hours postmatch. J Strength Cond Res 32(12): 3561–3572, 2018—Assessing responses to soccer match play is limited by match variability or unrealistic simulations. To address this, the biological, perceptual, and performance responses were assessed using a self-paced, simulated soccer match protocol using a nonmotorized treadmill. Twelve male team-sport athletes performed the 90-minute simulation. Match activity, quadriceps twitch interpolation (voluntary activation [%VA] and potentiated twitch [POT]), biochemical markers, strength and power performance, rating of perceived exertion (RPE), and self-report wellness were collected prematch, halftime, postmatch, and 2, 24, 48, 72, and 96-hour postmatch. Change compared with prematch was calculated using effect size ±90% confidence limit, and relationships were assessed using regression analysis. Subjects covered 12,445.8 ± 768.7 m at 87.1 ± 3.2% maximal heart rate (mean ± SD). Reductions in %VA and POT was present at halftime (−0.38 ± 0.46 and −0.79 ± 0.30, respectively) and persisted postmatch. Squat jump height decreased at halftime (−0.42 ± 0.31) and was decreased until Post96. Perceptual fatigue, soreness (−0.92 ± 0.88 and −1.49 ± 0.76, respectively), and creatine kinase (CK) (1.11 ± 0.43) peaked at Post24. Pretest strength (N·kg−1) correlated with changes in CK (r = −0.58 to −0.81), peak oxygen consumption (V[Combining Dot Above]O2peak) correlated with reduced perceived wellness at Post24 (r = 0.44–0.58) and RPE post (r = −0.71 ± 0.28). High-speed running correlated with soreness (r2 = 0.42) and very high-speed running with reduced POT (r2 = 0.61). Previously, unreported half-time reductions in %VA and POT plateaued by postmatch, suggesting a role in regulating second-half performance. Perceptual and neuromuscular responses seem related to running intensity. Greater lower-body strength and V[Combining Dot Above]O2peak were associated with less CK (i.e., muscle damage) and perceptual responses postmatch, respectively, suggesting a training focus should be placed on these capacities.
Is it necessary to administer anti‐D to prevent RhD immunization after the transfusion of RhD‐positive platelet concentrates?

Serology for the presence of anti‐D after RhD‐incompatible platelet transfusions was performed in 24 RhD‐negative patients with haematological disease and 59 RhD‐negative patients with non‐haematological disease. None of the patients were given prophylaxis with anti‐D to prevent RhD immunization. Eight out of 59 (13·5%) non‐haematology patients developed detectable anti‐D, whereas 0 out of 24 (0%) of the haematology patients formed anti‐D (P = 0·06). The risk of alloimmunization after RhD‐incompatible platelet transfusions using platelet concentrates prepared by modern technical methods appears to be small in patients with haematological disease, but is significant in non‐immunocompromised patients.
No increased risk of malignancies and mortality in cyclosporin A-treated patients with rheumatoid arthritis.

OBJECTIVE To evaluate the cyclosporin A (CSA)-attributed risk of developing malignancies in general and malignant lymphoproliferative diseases (LPDs) and skin cancers in particular, as well as the CSA-attributed incidence of mortality in patients with rheumatoid arthritis (RA). METHODS In a retrospective, controlled cohort study, the incidence of malignancies and mortality was evaluated in 208 CSA-treated patients with RA compared with 415 matched control patients with RA between 1984 and 1995. Patients were followed up for a median of 5.0 years (range 1.4-12.0). RESULTS Forty-eight cases of malignancy (8 in the CSA group and 40 in the control group; relative risk [RR] 0.40, 95% confidence interval [95% CI] 0.19-0.84) were identified, of which 8 were malignant LPDs (2 CSA versus 6 control; RR 0.67, 95% CI 0.14-3.27) and 14 were skin cancers (2 CSA versus 12 control; RR 0.33, 95% CI 0.08-1.47). Seventy-three patients died (16 CSA versus 57 control; RR 0.56, 95% CI 0.33-0.95) due primarily to cardiovascular diseases (4 CSA versus 22 control; RR 0.36, 95% CI 0.13-1.04) or a malignancy (3 CSA versus 8 control; RR 0.67, 95% CI 0.18-2.43). Proportional hazards regression analysis with correction for potential confounding factors did not significantly change the results. CONCLUSION The study findings suggest that CSA treatment in RA patients does not increase the risk of malignancies in general or the risk of malignant LPDs or skin cancers in particular. Moreover, the incidence of mortality in CSA-treated RA patients was comparable to that in matched control RA patients.
Smoking cessation and risk of type 2 diabetes mellitus: Korea Medical Insurance Corporation Study

Background To investigate the independent effects of smoking cessation on the risk for developing type 2 diabetes mellitus (DM) in the general population. Design An 8-year prospective study. Methods This prospective study started with baseline examinations in 1990 and 1992, and continued with follow-up examinations every 2 years up to 1998 and 2000. A total of 27635 nondiabetic men, aged 35–44 years were classified as 5701 nonsmokers, 7477 ex-smokers and 14457 sustained smokers, based on repeated self-reported questionnaires in 1992, 1994 and 1996. Baseline fasting serum glucose level and other risk factors were measured in 1990 and 1992. The outcome was newly developed DM, defined as a fasting glucose level ≥7.0mmol/l in 1998 and 2000 (averaged). Results Over the 8 years, 1170 men (4.2%) developed DM. When compared with nonsmokers, the fully adjusted risk ratio of ex-smokers and sustained smokers for diabetes was 1.22 [95% confidence interval (CI), 0.96–1.55] and 1.60 (95% CI, 1.29–1.97), respectively. Among the ex-smokers, the risk for diabetes differed according to the quit-smoking period. Compared with nonsmokers, the fully adjusted risk ratio for DM in men who quit smoking before 1992, during 1992–1993 and during 1994–1995 was 0.95 (0.72–1.25), 1.44 (0.96–2.15) and 2.13 (1.51–3.00), respectively, after adjustment for age, baseline fasting serum glucose, weight change, baseline body mass index, family history of DM, alcohol consumption and exercise status. Conclusions Our results support cigarette smoking as an independent and modifiable risk factor for DM. Early smoking cessation could decrease the risk for developing DM to that of nonsmokers in the long term.
THE INFLUENCE OF SOCIAL SUPPORT AND FINANCIAL MANAGEMENT TOWARD FAMILY WELL-BEING IN EARLY MARRIAGE

Aim of this study is to examine the influence of social support and financial management toward family well-being in early marriage. Research was located in Cibeber II village and Karehkel village, Leuwiliang sub-district, Bogor district, West Java. Samples of this study are 60 women from an early marriage family (under 20 years old) whose children are under five years old, and willingly participate in this study. Samples were chosen purposively. Social support were positively significant correlation with financial management, objective well-being and subjective well-being. The factors that affect objective family well-being are per capita income and financial management. On the subjective family well-being, the factor of affect is per capita income and emotional social support
Childhood Hemorrhagic Stroke

Hemorrhagic stroke in children occurs more frequently than is commonly appreciated. There are important differences in the factors associated with hemorrhagic stroke in children when compared with adults. These differences likely play a role in the different outcomes, which tend to worsen with age. In this review, we describe the estimated frequency, clinical presentation, acute management of hemorrhagic stroke, and an overview of rehabilitation techniques. We identify key topics for future basic and clinical research. Findings from future studies will help improve our ability to optimize treatment for and long-term rehabilitation of these patients.
Computer‐based Training in der Dermatoonkologie – erste Ergebnisse zum Vergleich elektronischer Lernprogramme mit Präsenzlehre

Hintergrund: Elektronische Medien spielen in der medizinischen Ausbildung eine zunehmende Rolle. Es stellt sich die Frage, wie Computerlernprogramme im Vergleich zu innovativen didaktischen Konzepten im Präsenzunterricht abschneiden.
When Low Market Values are No Bad News: On the Coordination of Renewable Support and Real-Time Pricing

We analyze the interactions between different renewable support schemes and the benefits of real-time pricing (RTP) using a stylized economic model with a detailed demand-side representation calibrated to the German market. We find that there are considerable differences between a market premium on energy and capacity regarding wholesale prices, support levies and market values, which are all related to induced negative wholesale prices in case of the former. This comes along with overall higher welfare as it allows RTP consumers to increase their consumption in periods of high renewable availability. Moreover, increasing RTP shares also incurs higher welfare gains in case of a premium on energy, with the deployment-relevant group of consumers that switch from a flat-rate tariff to RTP benefiting most. Our analysis thus puts the widespread notion that higher market values are instrumental for the deployment of high shares of RES into perspective.
Ecopayments and Deforestation in Costa Rica: A Nationwide Analysis of PSA’s Initial Years

We offer a nationwide analysis of the initial years of Costa Rica’s PSA program, which pioneered environmental-services payments and inspired similar initiatives. Our estimates of this program’s impact on deforestation, between 1997 and 2000, range from zero to one-fifth of 1% per year (i.e., deforestation is avoided on, at most, 2 out of every 1,000 enrolled hectares). The main explanation for such a low impact is an already low national deforestation rate. We also consider the effect of enrollment. Predicted deforestation on enrolled versus nonenrolled hectares, and matching analyses suggest an enrollment bias toward lower clearing threat. Enrolling land facing higher threat could raise payments’ impact on deforestation. (JEL Q24, Q28)
Modélisation de la dépendance et simulation de processus en finance

La premiere partie de cette these est consacree aux methodes numeriques pour la simulation de processus aleatoires definis par des equations differentielles stochastiques (EDS). Nous commencons par l’etude de l’algorithme de Beskos et al. [13] qui permet de simuler exactement les trajectoires d’un processus solution d’une EDS en dimension 1. Nous en proposons une extension a des fins de calcul exact d’esperances et nous etudions l’application de ces idees a l’evaluation du prix d’options asiatiques dans le modele de Black & Scholes. Nous nous interessons ensuite aux schemas numeriques. Dans le deuxieme chapitre, nous proposons deux schemas de discretisation pour une famille de modeles a volatilite stochastique et nous en etudions les proprietes de convergence. Le premier schema est adapte a l’evaluation du prix d’options path-dependent et le deuxieme aux options vanilles. Nous etudions egalement le cas particulier ou le processus qui dirige la volatilite est un processus d’Ornstein-Uhlenbeck et nous exhibons un schema de discretisation qui possede de meilleures proprietes de convergence. Enfin, dans le troisieme chapitre, il est question de la convergence faible trajectorielle du schema d’Euler. Nous apportons un debut de reponse en controlant la distance de Wasserstein entre les marginales du processus solution et du schema d’Euler, uniformement en temps. La deuxieme partie de la these porte sur la modelisation de la dependance en finance et ce a travers deux problematiques distinctes : la modelisation jointe entre un indice boursier et les actions qui le composent et la gestion du risque de defaut dans les portefeuilles de credit. Dans le quatrieme chapitre, nous proposons un cadre de modelisation original dans lequel les volatilites de l’indice et de ses composantes sont reliees. Nous obtenons un modele simplifie quand la taille de l’indice est grande, dans lequel l’indice suit un modele a volatilite locale et les actions individuelles suivent un modele a volatilite stochastique compose d’une partie intrinseque et d’une partie commune dirigee par l’indice. Nous etudions la calibration de ces modeles et montrons qu’il est possible de se caler sur les prix d’options observes sur le marche, a la fois pour l’indice et pour les actions, ce qui constitue un avantage considerable. Enfin, dans le dernier chapitre de la these, nous developpons un modele a intensites permettant de modeliser simultanement, et de maniere consistante, toutes les transitions de ratings qui surviennent dans un grand portefeuille de credit. Afin de generer des niveaux de dependance plus eleves, nous introduisons le modele dynamic frailty dans lequel une variable dynamique inobservable agit de maniere multiplicative sur les intensites de transitions. Notre approche est purement historique et nous etudions l’estimation par maximum de vraisemblance des parametres de nos modeles sur la base de donnees de transitions de ratings passees
Instructor Adoption of E-learning Systems in Tanzania’s Universities: A Proposed Multi-Factors Adoption Model (MFAM11)

Current studies show that there is no comprehensive adoption model in e-learning systems in universities. This problem opens up to too much debates about which models and frameworks fit well in an e-learning environment particularly in universities in Tanzania. This paper answers the two debatable questions, which are:(1) what are the factors that affect adoption of e-learning systems in Tanzania’s universities, (2) what is the comprehensive e-learning adoption model in universities in Tanzania. This research study adapts DeLone and McLean (2003) IS model after an extensive literature reviews conducted in information systems and in e-learning systems. The findings from this research will add up to literature of limited factors’ model and it will open it up for validation in a different universities’ application domain.
Natural prolongations of BGG-operators

BGG-Operatoren bilden eine Sequenz naturlicher Differentialoperatoren auf naturlichen Bundeln uber parabolischen Geometrien. Die BGG-Sequenz wurde zuerst in [Cap-Slovak-Soucek, 2001] konstruiert, eine einfachere Konstruktion wurde in [Calderbank-Diemer, 2001] prasentiert. Der erste Operator in dieser Sequenz ist uberbestimmt und legt die Frage nahe, ob eine Prolongation des zugehorigen uberbestimmten Systems konstruiert werden kann. In der vorliegenden Arbeit wird diese Frage positiv beantwortet: Es wird eine nat\"urliche Prolongationsmethode fur erste BGG-Operatoren von beliebigen Traktorbundeln regularer parabolischer Geometrien vorgestellt. Diese Prolongation kann insbesondere auf invariante Operatoren in der projektiven und konformen Geometrie angewandt werden. Wir werden mehrere BGG-Operatoren und zugeh\"orige Prolongations-Probleme fur projektive Strukturen betrachten. Fur konforme Strukturen werden wir die gut bekannten Operatoren welche almost Einstein scales und Twistor-Spinoren beschreiben betrachten und die Prolongation der konformen Killing-Gleichung im Detail besprechen. Schliesslich werden wir Techniken aus der Konstruktion der BGG-Sequenz auf eine verallgemeinerte Fefferman-Konstruktion anwenden, welche in [Nurowski, 2005], [Sagerschnig, 2008] und [Cap-Sagerschnig, 2009] betrachtet wurde. Wir erhalten eine Charakterisierung der assoziierten konformen Strukturen in Termen von normalen konformen Killing zwei-Formen, eine weitere Charakterisierung mittels Twistor-Spinoren und daruberhinaus eine Zerlegung von konformen Killing-Feldern.
Prenatal Diagnosis of De Novo Reciprocal Translocation t(1;12)(q21.3;p11.2) with Trisomy 21 and Sperm FISH Analysis for Increased Aneuploidy Risk

Abstract Complex rearrangements such as de novo translocations together with aneuploidy are unusual situations in prenatal diagnosis. We report a case with de novo translocation t(1;12)(q21.3;p11.2) and trisomy 21. Father’s sperm was analyzed for potential of increased risk of aneuploidy. Results showed no paternal increased risk for chromosomes 13, 18, 21, X, Y. Based on our results, we suggest that possible increased maternal aneuploidy risk and other possible mechanisms should be investigated to better understand cell division errors and to give better genetic counseling.
Development and Evaluation of EPA Method 1615 for Detection of Enterovirus and Norovirus in Water

ABSTRACT The U.S. EPA developed a sample concentration and preparation assay in conjunction with the total culturable virus assay for concentrating and measuring culturable viruses in source and drinking waters as part of the Information Collection Rule (ICR) promulgated in 1996. In an effort to improve upon this method, the U.S. EPA recently developed Method 1615: Measurement of Enterovirus and Norovirus Occurrence in Water by Culture and RT-qPCR. Method 1615 uses a culturable virus assay with reduced equipment and labor costs compared to the costs associated with the ICR virus method and introduces a new molecular assay for the detection of enteroviruses and noroviruses by reverse transcription-quantitative PCR. In this study, we describe the optimization of several new components of the molecular assay and examine virus recovery from ground, reagent-grade, and surface water samples seeded with poliovirus type 3 and murine norovirus. For the culturable virus and molecular assays, mean poliovirus recovery using the complete method was 58% and 20% in groundwater samples, 122% and 39% using low-titer spikes in reagent-grade water, 42% and 48% using high-titer spikes in reagent-grade water, and 11% and 10% in surface water with high turbidity, respectively. Murine norovirus recovery by the molecular assay was 30% in groundwater samples, less than 8% in both low- and high-titer spikes in reagent-grade water, and 6% in surface water with high turbidity. This study demonstrates the effectiveness of Method 1615 for use with groundwater samples and highlights the need for further research into its effectiveness with surface water.
Isolation by resistance across a complex coral reef seascape

A detailed understanding of the genetic structure of populations and an accurate interpretation of processes driving contemporary patterns of gene flow are fundamental to successful spatial conservation management. The field of seascape genetics seeks to incorporate environmental variables and processes into analyses of population genetic data to improve our understanding of forces driving genetic divergence in the marine environment. Information about barriers to gene flow (such as ocean currents) is used to define a resistance surface to predict the spatial genetic structure of populations and explain deviations from the widely applied isolation-by-distance model. The majority of seascape approaches to date have been applied to linear coastal systems or at large spatial scales (more than 250 km), with very few applied to complex systems at regional spatial scales (less than 100 km). Here, we apply a seascape genetics approach to a peripheral population of the broadcast-spawning coral Acropora spicifera across the Houtman Abrolhos Islands, a high-latitude complex coral reef system off the central coast of Western Australia. We coupled population genetic data from a panel of microsatellite DNA markers with a biophysical dispersal model to test whether oceanographic processes could explain patterns of genetic divergence. We identified significant variation in allele frequencies over distances of less than 10 km, with significant differentiation occurring between adjacent sites but not between the most geographically distant ones. Recruitment probabilities between sites based on simulated larval dispersal were projected into a measure of resistance to connectivity that was significantly correlated with patterns of genetic divergence, demonstrating that patterns of spatial genetic structure are a function of restrictions to gene flow imposed by oceanographic currents. This study advances our understanding of the role of larval dispersal on the fine-scale genetic structure of coral populations across a complex island system and applies a methodological framework that can be tailored to suit a variety of marine organisms with a range of life-history characteristics.
Synergetic effects of silver and gold nanoparticles in the presence of radiofrequency radiation on human kidney cells

Objective: The aim of this study was to compare the effects of radiofrequency radiation (RF) in synergism with gold (Au) and silver (Ag) nanoparticles (NPs) on the survival fraction of human normal kidney (HNK) and human embryonic kidney (HEK) cells. Materials and Methods: HNK and HEK cells were divided into three groups as control, 1 and 2 h/day-irradiated groups for 8 days. To compare the effects of RF in the presence of Au-NPs and Ag-NPs, the cells were incubated with NPs during the irradiation. In other words, six other groups were designed for the cell incubated with Au-NPs and Ag-NPs including control, 1 and 2 h/day-irradiated groups for 8 days. Generalized estimating equation model was applied to consider the natural correlation of repeated measurements over the time. Results: The mean survival fractions of HNK + Ag-NPs and HEK + Au-NPs were 0.098 less, 0.184 and 0.055 more than HEK cells, respectively. Along with the time, the mean fraction in HEK + Ag-NPs and HEK + Au-NPs groups in comparison with the HEK increased by the rate of 0.005 and decreased by the rates of 0.01 and 0.005, respectively. The mean survival fractions in HEK + Ag-NPs and HEK + Au-NPs were significantly less than that of HEK cells (P < 0.05). Conclusions: RF radiation can affect both HNK and HEK cells when irradiated for 2 h/day for 8 days. The results showed that the Ag-NPs do not increase the synergistic effects of RF compared to the Au-NPs. RF radiation at the presence of Au-NPs can be used as an efficient treatment for melanoma.