Miracle-dz/UniFAR-FTUs huggingface dataset:
Prognostic factors of the short-term outcomes of patients with hepatitis B virus-associated acute-on-chronic liver failure

OBJECTIVE: To investigate the impact of the baseline status of patients with hepatitis B virus-associated acute-on-chronic liver failure on short-term outcomes. METHODS: A retrospective study was conducted that included a total of 138 patients with hepatitis B virus-associated acute-on-chronic liver failure admitted to the Department of Infectious Diseases, Taihe Hospital, Hubei University of Medicine, from November 2013 to October 2016. The patients were divided into a poor prognosis group (74 patients) and a good prognosis group (64 patients) based on the disease outcome. General information, clinical indicators and prognostic scores of the patients’ baseline status were analyzed, and a prediction model was established accordingly. RESULTS: Elder age, treatment with artificial liver support systems and the frequency of such treatments, high levels of white blood cells, neutrophils, neutrophil count/lymphocyte count ratio, alanine aminotransferase, gamma-glutamyl transferase, total bilirubin, urea, and prognostic scores as well as low levels of albumin and sodium were all significantly associated with the short-term outcomes of hepatitis B virus-associated acute-on-chronic liver failure. The predictive model showed that logit (p) = 3.068 + 1.003 × neutrophil count/lymphocyte count ratio - 0.892 × gamma-glutamyl transferase - 1.138 × albumin - 1.364 × sodium + 1.651 × artificial liver support therapy. CONCLUSION: The neutrophil count/lymphocyte count ratio and serum levels of gamma-glutamyl transferase, albumin and sodium were independent risk factors predicting short-term outcomes of hepatitis B virus-associated acute-on-chronic liver failure, and the administration of multiple treatments with artificial liver support therapy during the early stage is conducive to improved short-term outcomes.
Effect of activating signal bandwidth on acoustic-reflex thresholds.

Acoustic‐reflex thresholds were determined as a function of activating‐signal bandwidth in 10 subjects with normal hearing sensitivity and eight subjects with noise‐induced sensorineural hearing loss. Acoustic‐reflex thresholds were measured by monitoring the acoustic impedance at the tympanic membrane for multicomponent activating stimuli centered logarithmically around 250, 500, 1000, 2000, and 4000 Hz. Normal listeners displayed monotonically decreasing acoustic‐reflex thresholds as bandwidth was increased by adding additional components to the complex activating signals. A knee in the functions occurred at values of bandwidth similar to previously reported critical bandwidths for the acoustic reflex. Sensorineural hearing loss altered the functions such that acoustic‐reflex thresholds tended to be elevated when the spectral content of the activating signal extended into the hearing‐loss region. This resulted in flatter functions relating acoustic‐reflex thresholds to activating‐signal bandwidth.
Topical n-docosanol for management of recurrent herpes labialis

Importance of the field: Recurrent herpes labialis (RHL) is a significant disorder with social and health consequences that affects upwards of 20 – 40% of the adult population. Docosanol is the only FDA-approved topical agent that is available over the counter for management of RHL. Its mechanism of action is unique compared with other available antiviral agents. Areas covered in this review: The authors conducted a comprehensive search of the published preclinical and clinical literature on topical docosanol for RHL. All of the published literature relating to docosanol and its use for the management of recurrent herpes labialis was reviewed, from the first report of docosanol to 31 January 2010. What the reader will gain: The objective of this review was to summarize and critically evaluate the available literature with respect to topical docosanol's mechanism, safety and efficacy in the management of RHL. Take home message: Ten percent docosanol cream is a safe and effective topical treatment for the management of RHL in immunocompetent adults, with essentially equivalent efficacy compared with other available prescription topical antiviral agents. Owing to its unique mechanism of action, there is little to no risk of developing resistance.
A genetic‐diagnostic survey in an institutionalized population of 173 severely mentally retarded patients

In this report we summarize the findings in a genetic‐diagnostic survey of an institutionalized population of 173 severely mentally retarded patients. The etiological study was based on a clinical genetic approach with special attention for dysmorphology and neurological findings. A constitutional disorder, as the direct cause of the severe mental handicap, was found in 75 patients (43.35%). A detailed survey of the different data and findings are given, and compared with the results of previous studies.
Identification of Skeletal Remains

Alice M. Brues, Ph.D., is an Associate Professor of Anatomy at the School of Medicine, University of Oklahoma and is a Research Associate in Physical Anthropology at the Oklahoma University Museum. Dr. Brues has served as a staff member of the Southwestern Homicide Investigators' Seminar since 1954 and is available for consultation by law enforcement agencies on the identification of skeletal remains. In this paper the author discusses the various aspects of identification that can be derived from skeletons and human bones-EDITOR.
Long-term Results of a Multicenter Randomized, Comparative Trial of Modified CHOP versus THP-COP versus THP-COPE Regimens in Elderly Patients with Non-Hodgkin’s Lymphoma

In treating elderly non-Hodgkin’s lymphoma (NHL) patients, it is particularly important to use drugs that have a low incidence of adverse events and high efficacy. In this multicenter study, THP (pirarubicin)-COP (cyclophosphamide, vincristine, and prednisolone) was compared to two thirds dosage of full CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisolone) regimen with regard to both adverse events and efficacy. For a third group, etoposide (E) was added to the THP-COP regimen (THP-COPE) in order to achieve high dose-intensity. Subjects were 486 previously untreated patients, aged 65 or older (range, 65–92 years; median, 74 years), with NHL. Subjects were randomly assigned to receive THP-COP, two thirds CHOP, or THP-COPE. Four hundred and forty-three patients were assessed for response and followed for 8 years after the last subject registered. The complete remission rates for the THP-COP, CHOP, and THP-COPE groups were 42.5%, 41.4%, and 48.0%, respectively. There was no difference in overall survival or progression-free survival among these 3 groups. In aggressive lymphoma, there was also no difference in complete response (CR) rate (45.3% in THP-COP, 44.9% in CHOP, 48.0% in THP-COPE), overall survival, and progression-free survival among these groups. The 5- and 8-year survival rates for all patients were 29.4% and 18.7%, respectively. The 5- and 8-year survival rates for patients with aggressive lymphoma were 27.4% and 17.4%, respectively. Although long-term survival for patients with aggressive lymphoma on our regimens was not worse compared to previous reports, the CR rate was lower. Because severe adverse events were not observed, higher dose chemotherapy may be directed to achieve better CR rates. In patients with T-cell-type lymphoma, the CR rate was greater after treatment with THP-COP (51.4%) or THP-COPE (57.7%) compared to treatment with CHOP (19.4%). Pirarubicin may be more useful for T-cell lymphoma than doxorubicin. Because adverse cardiac events were reported only in CHOP, adverse cardiac events might be low in the THP group.
Palmprint Recognition Using Neighboring Direction Indicator

Orientation features are successfully used in coding-based palmprint recognition methods. In this paper, we propose a discriminative neighboring direction indicator to represent the orientation feature of the palmprint. The neighboring direction indicator feature not only represents the most dominant orientation feature of the palmprint, but also better describes the orientation feature of those points which have double dominant orientations. In addition, the neighboring direction indicator shows good robustness to noise and rotation. Using the neighboring direction indicator, we propose a novel palmprint recognition method. Extensive experiments conducted on three types of palmprint databases demonstrate that the proposed method gives better performance than the existing state-of-the-art orientation-based methods. By using the proposed method, the equal error rate is improved by about 10% for palmprint verification, and the average error rate is reduced by 2.7-14% for palmprint identification with a single training sample.
Optimal Search for Hidden Targets by Unmanned Aerial Vehicles under Imperfect Inspections

Assume that a target is hidden or lost in one of several possible locations and is to be found by the unmanned aerial vehicle (UAV). A target can be either a hostile object or missing personnel in remote areas. Prior probabilities of target locations are known. Inspection operations done by the UAVs are imperfect, namely, probabilities of overlooking the hidden target and probabilities of false alarms exist for any possible location. The UAV has to sequentially inspect the locations so that to find the target with the minimum loss or damage incurred by the target before it is detected subject to a required level of confidence of target identification. A fast (polynomial-time) priority-based algorithm for finding an optimal search strategy is developed.
Outcome after extended arch repair for aortic coarctation

Objectives: To assess survival and long term arch patency rates in a consecutive group of children after extended arch repair for coarctation of the aorta. Methods: Review of 191 consecutive children (154 (81%) under 1 year of age) operated on between 1990 and 2002 by a single surgeon using extended arch reconstructive techniques. For assessment of survival patients were divided into three groups: 1, coarctation alone, n = 104; 2, coarctation and ventricular septal defect, n = 38; and 3, coarctation in association with complex intracardiac anomalies, n = 49. A prospective and systematic clinical and echocardiographic evaluation of the aortic arch was undertaken. Results: Median time to follow up was 4.2 years (range 1–10.6 years). Overall actuarial survival was 92%, 88%, and 88% at two, five, and 10 years. Mortality was significantly higher in those patients with complex intracardiac anatomy. Arch obstruction recurred in seven of 165 (4.2%) patients: four of 139 (2.9%) term and three of 10 (30%) premature infants (p < 0.001). Conclusions: Survival after extended arch reconstruction for coarctation is excellent. At long follow up recurrent arch obstruction is rare, with prematurity the only risk factor.
Mitochondrial Energy Metabolism in Very Premature Neonates

The activity, amount and protein composition of pyruvate dehydrogenase (PDH) and respiratory chain complexes were studied in muscle mitochondria obtained postmortally from 6 neonates with a gestational age of 23–29 weeks. The activities of PDH and respiratory chain complex III and IV and citrate synthase were significantly lower in comparison with control children aged 0.5–2 and 2–20 years. Protein analyses revealed a parallel decrease in the content of PDH, respiratory chain complexes and their subunits in the cases analyzed. The observed immaturity of the mitochondrial energy-providing system suggests that significant development of mitochondrial energy metabolism occurs during the last 3 months of prenatal development. The metabolic disturbances of mitochondrial energy conversion associated with the low functional capacity and content of PDH and respiratory chain complexes may play an important role in the morbidity of very premature neonates.
Association of cardiorespiratory fitness, body mass index, and waist circumference to nonalcoholic fatty liver disease.

BACKGROUND & AIMS There is a need for more work examining the potential of physical activity and/or weight control as a preventive and/or therapeutic option in the treatment of fatty liver diseases. The purpose of this study was to examine the association between cardiorespiratory fitness, body mass index (BMI), and waist circumference with markers of nonalcoholic fatty liver disease (NAFLD). METHODS Participants consisted of 218 apparently healthy nonsmoking, nonalcoholic men aged 33-73 years. Cardiorespiratory fitness was assessed by a maximal treadmill test. Liver and spleen density were measured using a computed tomography scan. We defined the presence of NAFLD as the following 3 conditions being met: (1) liver to spleen density of 1.0 or less, (2) serum alanine transaminase level greater than 30 U/L, and (3) serum aspartate transaminase/alanine transaminase level less than 1.0. RESULTS Twenty-four (11%) of the participants met the NAFLD definition. There was an inverse association between fitness categories, and a positive association for BMI categories (and waist circumference categories) with the prevalence of NAFLD (P for trend <.001 for all). Fitness and BMI were independent of each other in their associations with the prevalence of NAFLD. The addition of waist circumference to the regression model attenuated the association with prevalence of NAFLD for both fitness (P value changed from <.0001 to .06) and BMI (P value changed from <.001 to .22). CONCLUSIONS Fitness (inversely) and BMI (directly) were associated with the prevalence of NAFLD. However, these associations were attenuated when abdominal obesity was included in the statistical model.
Development of simple standard assay procedures for the characterization of snake venom.

In accordance with the recommendations of the report of a WHO Coordination Meeting on Venoms and Antivenoms, methods have been developed for the assessment of lethal, defibrinogenating, procoagulant, haemorrhagic, and necrotizing properties of venoms, and used to study 53 venoms from 30 different species of snakes of medical importance throughout the world. The venoms studied included Echis carinatus (Iran), Naja naja kaouthia (Thailand), Notechis scutatus (Australia), Trimeresurus flavoviridis (Japan), Vipera russelli (Thailand), and Crotalus atrox (USA), which comprise six of the eight venoms designated by WHO as international reference venoms (IRVs). (C. atrox venom replaced C. adamanteus venom, as an adequate supply of the latter was not available.) The tests used were simple and should be reproducible in other laboratories throughout the world. Procedures for assaying neuromuscular paralytic activity and systemic myotoxic activity have yet to be developed.The tests will be used to assay the neutralizing potency of both international standard antivenoms (raised using the IRVs) and new and currently available commercial antivenoms. Such studies should result in the production of more potent antivenoms for use in both developing and developed countries, and improve the understanding and management of snake bite throughout the world.
Significant Compatibility Does Not Exist at the HLA‐DQB Gene Locus in Couples With Unexplained Recurrent Abortions

ABSTRACT: The polymerase chain reaction‐restricted fragment length polymorphism (PCR‐RFLP) method was used for both examining compatibility at the HLA‐DQB1 gene locus and determining HLA‐DQ antigen polymorphism in spouses of unexplained recurrent abortions. Genomic DNA samples were prepared from peripheral mononuclear cells from patient and control couples. Two hundred and thirty base pair fragments of the second exon of the HLA‐DQB genes were selectively amplified. Amplified DNAs were digested with the restriction endonucleases, Fok I, Hae III, Hha I, Rsa I and Sau3A I, and subjected to electrophoresis in a polyacrylamide gel. The RFLPs showed that habitual aborters and their husbands had neither significantly frequent alleles nor shared common alleles at the HLA‐DQB locus when compared to the control group.
Anaplastic large‐cell lymphomas of B‐cell phenotype are anaplastic lymphoma kinase (ALK) negative and belong to the spectrum of diffuse large B‐cell lymphomas

There is controversy in the literature as to whether anaplastic large‐cell lymphoma of B‐cell phenotype is related to the t(2;5)‐positive T‐ or ‘null’ cell lymphoma of the same morphology. We report a study of 24 lymphomas with morphological features of anaplastic large‐cell lymphoma which expressed one or more B‐cell markers and lacked T‐lineage markers. Clinical features were more in keeping with large B‐cell lymphoma than with classical t(2;5)‐positive anaplastic large‐cell lymphoma, and immunostaining for anaplastic lymphoma kinase (ALK) protein provided no evidence for the (2;5) translocation (or one of its variants). The staining patterns for CD20 and CD79 were typical of diffuse large B‐cell lymphoma, CD30 expression was variable, and most cases (15/22) lacked epithelial membrane antigen (EMA). These findings support the view that ‘B‐cell anaplastic large‐cell lymphoma’ is unrelated to t(2;5)‐positive (ALK‐positive) lymphoma, and that it represents a morphological pattern occasionally encountered among diffuse large B‐cell lymphomas. By the same reasoning, most tumours diagnosed as ‘ALK‐negative anaplastic large‐cell lymphoma of T‐cell or null phenotype’ probably belong to the spectrum of peripheral T‐cell lymphomas.
Marketing to Healthy Lifestyle Consumers : An Analysis of Demographic and Social Cognitive Factors

Individuals who adopt a healthy lifestyle are excellent customers for health-related offerings. The present study represents the first attempt to examine group differences between “high active” and “low active” exercisers in demographic and social cognitive characteristics which aims to provide useful insights to marketers in segmenting markets, targeting promotions, and positioning products and services. Cross-sectional data was collected via self-administered surveys from general adults sample (n = 512) in Malaysia. Prior to data analysis, measurement scale was validated using confirmatory factor analysis. Significant differences were found between the two exercise groups in age, occupation and all the social cognitive factors studied. The “low active” group had less favourable instrumental and affective attitude, were less subject to social pressure, and felt less perceived control and self-efficacy over exercising compared to “high active” exercisers. The discriminant analysis reported perceived self-efficacy to be the most important factor in discriminating between the two groups.
A reconfigurable antenna construction toolkit with modular slotted waveguide elements for arbitrary pattern designs

This contribution presents a universal antenna construction toolkit with slotted waveguide elements which can flexibly be combined to form a reconfigurable antenna array capable of providing arbitrary symmetric radiation patterns. The design and the arrangement of radiating elements allow adjusting arbitrary real amplitudes of single radiating elements in a solely mechanical way without any electrical feeding network. Additional modular connecting elements even allow two dimensional and conformal antenna designs with circular or linear polarizations. With a single toolkit in the Ku-band several design and measurement examples are presented, such as a linear array forming a desired main lobe down to −20 dB, and a universal two dimensional antenna array that can switch between vertical, horizontal, LHC and RHC polarization. The waveguide toolkit is easily scalable to any other frequency band just being limited in the upper frequency by manufacturing issues. This universal antenna toolkit allows an accurate realization of antenna footprints for scattering measurements, but is also well-suited to teach group antenna theory and related measurements in a very flexible and interactive manner.
Amplification fragment length polymorphism in Brucella strains by use of polymerase chain reaction with arbitrary primers

DNA heterogeneity among members of the genus Brucella was demonstrated with the arbitrarily primed polymerase chain reaction (AP-PCR). Simple, reproducible genomic fingerprints from DNA of 25 different Brucella strains were generated with five arbitrarily chosen primers, alone and in pairs, with the PCR. Reaction conditions were optimized for each primer. Several DNA segments were amplified in each sample with all of the primers. PCR products that are not shared among all strains act as polymorphic markers. Polymorphism was apparent for each primer. The Brucella strains can be distinguished according to the banding patterns of their amplified DNA on agarose gels, and the differences can be diagnostic of specific strains. To determine genetic relatedness among the Brucella strains, similarity coefficients were calculated. Statistical analysis of the similarity coefficients revealed the degrees of relatedness among strains of the genus Brucella.
Regulation of fatty acid biosynthesis by hydrocarbon substrates in Mycobacterium convolutum

When Mycobacterium convolutum R22 was grown on the n-alkanes C13 through C16, the predominant fatty acids were of the same chain length as the growth substrate. Cells grown on C13 through C16 n-alkanes incorporated between 15 and 85 pmol of acetate per microgram of lipid into the fatty acids, whereas acetate- or propane-grown cells incorporated 280 and 255 pmol of acetate per microgram of lipid, respectively. In vivo experiments demonstrated that hexadecane, hexadecanoic acid, and hexadecanoylcoenzyme A (CoA) all inhibited de novo fatty acid synthesis. Hexadecanoyl-CoA was the most potent inhibitor. Hexadecane and hexadecanoic acid inhibited acetyl-CoA carboxylase by up to 37 and 39%, respectively, at 1 mM. Hexadecanoyl-CoA inhibited the enzyme activity by 65% at 50 micrometer. Cells that were grown on C14 through C16 n-alkanes had about 25 times less acetyl-CoA carboxylase activity than did cells grown on acetate or propane, suggesting repressed levels of the enzyme. Hexadecane- or pentadecane-grown cells were found to have 5 to 10 times more intracellular free fatty acid than cells grown on acetate, propane, or ethane.
Sporulation and the Production of Serine Protease and Cephamycin C by Streptomyces lactamdurans

Streptomyces lactamdurans, producer of the antibiotic cephamycin C, excretes at least two proteases. Physiological studies indicate that antibiotic synthesis and serine protease formation are coordinately regulated. Both are produced only after culture growth ends, and they appear with essentially identical kinetics. In addition, strains which produce superior levels of cephamycin C form equally superior levels of the serine protease. Genetic evidence reveals that the syntheses of the antibiotic and serine proteases are associated with sporulation. Mutants which fail to produce aerial hyphae (bald mutants) also fail to synthesize the antibiotic and serine proteases.
The onset of puberty in Tswana schoolboys: a need for sex education

Summary Spermaturia can be used as an indicator of genital and sexual maturation in puberty. In this study the mean age of the onset of puberty in Tswana schoolboys was determined. Of the boys between 10 and 13 years, only one (1.22%) aged 13 had spermaturia, compared with 61 boys (88.4%) in the group 14–16 years. The mean age of boys with spermaturia was 14.95 ± 0.85 years. The possible onset of puberty as calculated by the presence of spermaturia was between 14.10 and 15.80 years. It would seem, therefore, that from the age of 14 years, a boy might theoretically be able to father a child. The need for sex education at school is thus of paramount importance.