Miracle-dz/UniFAR-FTUs huggingface dataset:
An Open-Label Tolerability Study of BL-1020 Antipsychotic: A Novel Gamma Aminobutyric Acid Ester of Perphenazine

Background:BL-1020, a novel gamma aminobutyric acid (GABA) ester of perphenazine, is a new oral antipsychotic with a strong affinity for dopamine and serotonin receptors. Unlike first- and second-generation antipsychotics, it has agonist activity at GABAA. Objective:This is the first study to examine tolerability and safety of BL-1020 in schizophrenia. Methods:This was a phase-II, open-label, multicenter, 6-week study treating patients (n = 36) with chronic schizophrenia. Dosing started at 20 mg/d and increased over 7 days to 40 mg/d. Weekly assessments were conducted. Results:All but 1 patient was titrated to 30 mg/d at day 4; on day 7, 30 were titrated to 40 mg/d. Four patients discontinued the study prematurely. There was no clinically relevant increase in vital signs, sedation, dizziness, or other central nervous system effects or electrocardiogram or laboratory abnormalities and a small increase in weight. Ten patients experienced extrapyramidal symptoms (EPS) requiring treatment with an anticholinergic; 4 patients were unable to reach maximum dose because of EPS. Extrapyramidal Symptom Rating Scale did not indicate clinically significant changes in EPS. The most common adverse event was insomnia (6 patients); other frequent adverse effects (all n = 3) were extrapyramidal disorder, headache, parkinsonism, tremor, and hyperprolactinemia. There was improvement on Positive and Negative Syndrome Scale and Clinical Global Impression of Change with 22 patients showing at least 20% decrease by end point on Positive and Negative Syndrome Scale and 31 patients showing at least minimal improvement on Clinical Global Impression of Change. Conclusions:These data suggest that 20 to 40 mg/d of BL-1020 is associated with clinically relevant improvement of psychosis with no worsening of EPS and support further testing in randomized controlled trials.
How continuity of care is experienced within the context of integrated palliative care: A qualitative study with patients and family caregivers in five European countries

Background: Patients with advanced diseases often experience deficient continuity of care. Although integrated palliative care promotes continuity of care, it is not clear how it can be optimized to improve continuity of care experiences. Aim: To examine how relational, informational and management continuity of care are experienced by patients with advanced diseases and their family caregivers receiving care from several integrated palliative care initiatives in five European countries. Design: We adopted a longitudinal qualitative study design including two interviews (interval 3 months) with patients and family caregivers focusing on how health care professionals responded to their needs. Interviews were audio-recorded and transcribed verbatim. Analysis involved a two-step qualitative content approach. Setting/participants: A total of 22 integrated palliative care initiatives (established local palliative care collaborations) were selected in Belgium, Germany, Hungary, the Netherlands and the United Kingdom. We recruited 152 patients (63% cancer, 24% chronic obstructive pulmonary disease, 13% heart failure; life expectancy <1 year; mean age 68 years, 56% female) and 92 family caregivers (mean age 61 years, 66% female). Results: Trusted relationships with a small number of key health care professionals to receive tailored care and easily access help were essential. Relational continuity was often deficient, especially with general practitioners. Although informational and management continuity was often lacking in care provision, collaborative integrated palliative care initiatives were related to consistent and coherent care. Conclusion: Patients and family caregivers most likely experience continuity of care by having a small number of trusted health care professionals who are available, provide multidisciplinary care and regularly transfer information to all health care professionals involved. Optimizing continuity of care requires further integration of integrated palliative care initiatives with other health care professionals involved in the patients’ care networks.
Comparative study of acetaminophen-morphine versus rofecoxib-morphine for post-tonsillectomy pain control.

INTRODUCTION Although we routinely use morphine at our institution, moderate to severe pain often persists for several days after tonsillectomy. Nonsteroidal anti-inflammatory drugs could offer significant relief. Unfortunately, concerns about increased risk of bleeding limit their use. Selective inhibitors of cyclooxygenase type 2 (COX-2), such as rofecoxib, which do not affect bleeding time, could be an interesting option. OBJECTIVE To evaluate the efficiency and safety of "rofecoxib-morphine" versus "acetaminophen-morphine" for post-tonsillectomy pain control. METHOD Eighty children (5-17 years old) took part in this prospective comparative study. Forty children were in the acetaminophen-morphine group (group A), and the remaining 40 children were in the rofecoxib-morphine group (group R). Pain scores, administered doses of medication, side effects, and the general health status of the child were collected by telephone calls made on the first, third, and seventh days after surgery. RESULTS Pain scores for group A compared with group R are as follows: day 0 at home arrival, 4.6 to 2.5; day 0 average, 4.7 to 3.3; day 1, 3.6 to 2.6; day 3, 2.3 to 1.4; and day 7, 1.4 to 2.0. Moreover, children who received rofecoxib generally drank, ate, and returned to their regular activities more quickly than the children of group A. No side effects were reported with rofecoxib. CONCLUSION Rofecoxib (COX-2 inhibitor) significantly reduces pain scores after pediatric tonsillectomy. The combination of rofecoxib and morphine is safe and helps children return more quickly to their activities.
LEXICAL COLLOCATIONS: ISSUES IN TEACHING AND WAYS TO RAISE AWARENESS

Vocabulary knowledge is considered essential in using a foreign language either in spoken or written forms. Therefore, it is common to hear language learners referring to their poor vocabulary knowledge when they fail to produce enough content in writing or speaking. As it is estimated that there are almost 20,000 million words in English, they mention it as a reason for their misuse of words, phrases and collocations. It is too ambitious to aim language learners to learn that many words to communicate effectively in English, yet because language is phrasal in its nature, awareness and knowledge of collocations, i.e. words that occur together, may help learners comprehend written and spoken discourse (Wray, 2002). This article focuses on the nature and formation of collocations and the issues in learning and teaching collocations especially in foreign language settings. In an attempt to raise awareness of collocations, some practical ideas are also suggested. Article visualizations:
The effectiveness of school-based decision making in improving educational outcomes: a systematic review

ABSTRACT The rhetoric around decentralisation suggests school-based management improves education outcomes. Existing reviews on school-based decision-making have tended to focus on proximal outcomes and offer very little information about why school-based decision-making has positive or negative effects in different circumstances. The authors systematically searched for and synthesised evidence from 35 quantitative and qualitative studies evaluating 17 individual interventions on the effectiveness of school-based decision-making on educational outcomes. Devolving decision-making to the level of the school appears to have a somewhat beneficial effect on dropout, repetition and teacher attendance. Effects on test-scores are more robust, being positive in aggregate and for middle-income countries specifically. On the other hand, school-based decision-making reforms appear to be less effective in communities with generally low levels of education, where parents have low status relative to school personnel. The authors conclude that school-based decision-making reforms are less likely to be successful in highly disadvantaged communities.
Modelling Sector-Level Asset Prices

We present a modelling approach for sector asset pricing studies that incorporates sector-level risk factors, subgroup portfolios, and structural breakpoint tests that are better at isolating the time-varying nature and the firm-specific component of returns. Our results show considerable subsector heterogeneity, while the asset pricing model using local risk factors and inductive structural breaks results in a superior model ( R 2 of 80.42% relative to R 2 of 68.79% of “conventional” models). Finally, we show that some of the variances of residuals, normally assumed to be the firm-specific component of returns, can be attributed to the changing relationship between sector returns and risk factors.
Self-Resonant Flow Sensor using Resonance Frequency Shift by Flow-Induced Vibration

A self-resonant flow sensor using resonance frequency shift by the flow-induced vibration is presented. All of MEMS-based flow sensors have measured thermal flux, mechanical strain, capacitance, and so on. In this paper, we used self-resonant vibration induced by a fluid flow and resonant frequency shift by a surface stress on the cantilever beam due to fluid drag force in order to measure mass flow. Vibration induced by air flow was measured by the piezoelectric material of PZT on the silicon cantilever beam. Theoretical resonant frequency of the cantilever beam (610 ¿m×300 ¿m×3.3 ¿m) was 12,416Hz. For the air flow velocities of 2.8m/sec and 9.7m/sec, shifted resonant frequencies were 12,810Hz and 15,602Hz, respectively. Sensitivity of the present self-resonant flow sensor was approximately 384Hz/(m/sec).
A prospective study of nosocomial urinary tract infection in hip fracture patients.

AIM To investigate risk factors and consequences of nosocomial urinary tract infection in hip fracture patients. BACKGROUND Nosocomial urinary tract infection is a well-known problem in hip fracture patients. There are several risk factors for nosocomial urinary tract infection described in the literature. DESIGN Prospective observational study with a descriptive and comparative design. METHODS Hip fracture patients were included consecutively between April 2006-March 2007. Excluded were those under 50, having an indwelling urinary catheter, signs of cognitive impairment or additional severe physical problems at the time of admission. To verify nosocomial urinary tract infection, a urine specimen was taken at admission and discharge. Patients with and without nosocomial urinary tract infection were compared. RESULTS The study included 86 hip fracture patients, of whom 45 (52·3%) contracted nosocomial urinary tract infection in hospital. Earlier reported risk factors for nosocomial urinary tract infection were not confirmed in this study, with one exception: diabetes. All diabetic patients in the study contracted urinary tract infections. Patients receiving cloxacillin as antibiotic prophylaxis for wound infection contracted UTI less often than other patients. There were no statistical differences between groups with regard to urinary tract infection frequency four months after fracture or with regard to mortality after one year. CONCLUSION Diabetes was the only previously known risk factor for nosocomial urinary tract infection confirmed among hip fracture patients in this study. Cloxacillin as antibiotic prophylaxis for surgery seemed to offer a certain protection against nosocomial urinary tract infection. RELEVANCE TO CLINICAL PRACTICE Nurses in clinical practice should be aware of the risk of urinary tract infections in hip fracture patients and especially in hip fracture patients with diabetes. Patients given cloxacillin as antibiotic prophylaxis seem less likely to contract nosocomial urinary tract infection.
Semi-decentralized adaptive fuzzy control for cooperative multirobot systems with Hinfin motion/internal force tracking performance

We present a semi-decentralized adaptive fuzzy control scheme for cooperative multirobot systems to achieve H(infinity) performance in motion and internal force tracking. First, we reformulate the overall system dynamics into a fully actuated system with constraints. To cope with both parametric and nonparametric uncertainties, the controller for each robot consists of two parts: 1) model-based adaptive controller; and 2) adaptive fuzzy logic controller (FLC). The model-based adaptive controller handles the nominal dynamics which results in both zero motion and internal force errors for a pure parametric uncertain system. The FLC part handles the unstructured dynamics and external disturbances. An H(infinity) tracking problem defined by a novel performance criterion is given and solved in the sequel. Hence, a robust controller satisfying the disturbance attenuation is derived being simple and singularity-free. Asymptotic convergence is obtained when the fuzzy approximation error is bounded with finite energy. Maintaining the same results, the proposed controller is further simplified for easier implementation. Finally, the numerical simulation results for two cooperative planar robots transporting an object illustrate the expected performance.
Signal strength regulates antigen-mediated T-cell deceleration by distinct mechanisms to promote local exploration or arrest

Significance To mount an efficient immune response, T cells need to recognize foreign antigen to become activated, proliferate, and acquire their effector functions. We show that T cells can adopt two behaviors depending on the strength of the antigen stimulation. Upon suboptimal stimulation, T cells adopt a scanning behavior that promotes local exploration of the microenvironment. Stronger stimulation triggers specific mechanisms that induce complete T-cell arrest. We propose that these distinct behaviors may represent an optimal strategy for T cells to find the strongest antigenic stimulation. T lymphocytes are highly motile cells that decelerate upon antigen recognition. These cells can either completely stop or maintain a low level of motility, forming contacts referred to as synapses or kinapses, respectively. Whether similar or distinct molecular mechanisms regulate T-cell deceleration during synapses or kinapses is unclear. Here, we used microfabricated channels and intravital imaging to observe and manipulate T-cell kinapses and synapses. We report that high-affinity antigen induced a pronounced deceleration selectively dependent on Ca2+ signals and actin-related protein 2/3 complex (Arp2/3) activity. In contrast, low-affinity antigens induced a switch of migration mode that promotes T-cell exploratory behavior, characterized by partial deceleration and frequent direction changes. This switch depended on T-cell receptor binding but was largely independent of downstream signaling. We propose that distinct mechanisms of T-cell deceleration can be triggered during antigenic recognition to favor local exploration and signal integration upon suboptimal stimulus and complete arrest on the best antigen-presenting cells.
The Impact of Acculturation and Biculturalism on the Second Generations Living in Canada

The present study explores the experience of second generation Canadian youth in terms of acculturation and possible negative psychological impacts. Stressors that are associated with second generation Canadian youth have been identified as acculturation, biculturalism, cultural conflict within relationships, being a visible minority, and discrimination. This study utilizes a narrative literature review methodology to explore the challenges faced by second generation Canadian youth. Through this literature review I was able to describe, examine, and evaluate research looking at stressors unique to second generation Canadian youth in order to provide a better understanding for counsellors. Findings from this literature review indicated that second generation Canadian youth, compared to other Canadian youth, are experiencing additional stressors that negatively impact mental health and overall well-being. Themes that emerged from this review include: the important role of family, peers and factors associated with the host society’s policies and attitude toward second generations. Marginalisation, discrimination, and lack of social support by the host society will create negative acculturation experience for second generation youth. However, acculturation pattern among second generation Canadian youth vary across ethnic groups and in order to avoid generalization more research is required to re-evaluate the story of second generation integration and closely examine day to day lived experiences of these generations in Canada.
Locomotion and scanning electron microscopic observations of primordial germ cells from the embryonic chick blood in vitro

The locomotion of chick primordial germ cells (PGCs) in vitro was observed using 16‐mm time‐lapse microcinematography and 35‐mm timelapse film. The PGCs isolated from circulating blood of stage 14 to 16 embryos (Hamburger and Hamilton, 1951) were cultured on a substrate of mesenchymal feeder cells obtained from the dorsal mesentery of stage 40 embryos, using modified medium 199 containing 10% fetal calf serum. The PGCs were found to move actively and to show a tendency to move along the longer axis of the underlying cells. The velocity of PGC locomotion averaged 26 μm/hr and reached 58 μm/hr as a maximum.
The Impact on Sexual Functioning of Chemotherapy-induced Menopause in Women With Breast Cancer

This article presents a comprehensive review and synthesis of empirical and conceptually based literature documenting the impact of chemotherapy-induced menopause on the sexual functioning of women with breast cancer. A literature search of the CINAHL, MEDLINE, and Psych Lit from 1980 to 1999 databases was undertaken. This literature was systematically assessed to determine key findings and conclusions. Two major themes were identified and are reported here: physical and psychological sequelae associated with altered sexual functioning. Recommendations and suggestions for further directions in research are identified.
Trading Data in the Crowd: Profit-Driven Data Acquisition for Mobile Crowdsensing

As a significant business paradigm, data trading has attracted increasing attention. However, the study of data acquisition in data markets is still in its infancy. Mobile crowdsensing has been recognized as an efficient and scalable way to acquire large-scale data. Designing a practical data acquisition scheme for crowd-sensed data markets has to consider three major challenges: crowd-sensed data trading format determination, profit maximization with polynomial computational complexity, and payment minimization in strategic environments. In this paper, we jointly consider these design challenges, and propose VENUS, which is the first profit-driVEN data acqUiSition framework for crowd-sensed data markets. Specifically, VENUS consists of two complementary mechanisms: VENUS-PRO for profit maximization and VENUS-PAY for payment minimization. Given the expected payment for each of the data acquisition points, VENUS-PRO greedily selects the most “cost-efficient” data acquisition points to achieve a sub-optimal profit. To determine the minimum payment for each data acquisition point, we further design VENUS-PAY, which is a data procurement auction in Bayesian setting. Our theoretical analysis shows that VENUS-PAY can achieve both strategy-proofness and optimal expected payment. We evaluate VENUS on a public sensory data set, collected by Intel Research, Berkeley Laboratory. Our evaluation results show that VENUS-PRO approaches the optimal profit, and VENUS-PAY outperforms the canonical second-price reverse auction, in terms of total payment.
Quality of Life, Symptom Distress, and Social Support Among Renal Transplant Recipients in Southern Taiwan: A Correlational Study

&NA; Quality of life is an important indicator for evaluating therapeutic outcomes and mortality in patients with end-stage renal disease. Few studies have explored the impact of symptom distress and social support on quality of life in this population. A correlational study was designed to examine the influence of symptom distress, social support and demographic characteristics on quality of life in renal transplant recipients. A convenience sample of 113 renal transplant recipients was recruited from a medical center in Southern Taiwan. A structured questionnaire was used to collect data. This four-part tool included: Quality of Life Index - Kidney Transplant Version III, Physical Symptom Distress Scale, Social Support Scale, and demographic characteristics. Data were analyzed by descriptive and inferential statistics (SPSS 10.1 statistical package). Percentage, rank, mean and standard deviation, t-tests, chi-square, ANOVA, Pearson's correlation and multiple regression were computed. Results showed that renal transplant recipients had a moderate quality of life. Social support and symptom distress, age, employment status, and household income significantly explained 28.8% of the variance in quality of life. Findings suggest implications for interventional programming and research aimed toward improving quality of life, including individual and family-based approaches designed to enhance recipients' social support and address effective management of symptoms. Recruiting a transplant clinical nurse specialist to design and implement an intervention program also is recommended.
Comparison of direct sampling and brochoalveolar lavage for determining active drug concentrations in the pulmonary epithelial lining fluid of calves injected with enrofloxacin or tilmicosin

Antibiotic distribution to interstitial fluid (ISF) and pulmonary epithelial fluid (PELF) was measured and compared to plasma drug concentrations in eight healthy calves. Enrofloxacin (Baytril® 100) was administered at a dose of 12.5 mg/kg subcutaneously (SC), and tilmicosin (Micotil® 300) was administered at a dose of 20 mg/kg SC. PELF, sampled by two different methods-bronchoalveolar lavage (BAL) and direct sampling (DS)-plasma, and ISF were collected from each calf and measured for tilmicosin, enrofloxacin and its metabolite ciprofloxacin by HPLC. Pharmacokinetic analysis was performed on the concentrations in each fluid, for each drug. The enrofloxacin/ciprofloxacin concentration as measured by AUC in DS samples was 137 ± 72% higher than in plasma, but in BAL samples, this value was 535 ± 403% (p < .05). The concentrations of tilmicosin in DS and BAL samples exceeded plasma drug concentrations by 567 ± 189% and 776 ± 1138%, respectively. The enrofloxacin/ciprofloxacin concentrations collected by DS were significantly different than those collected by BAL, but the tilmicosin concentrations were not significantly different between the two methods. Concentrations of enrofloxacin/ciprofloxacin exceeded the MIC values for bovine respiratory disease pathogens but tilmicosin did not reach MIC levels for these pathogens in any fluids.