Miracle-dz/UniFAR-FTUs huggingface dataset:
A Fully-Integrated 77-GHz UWB Pseudo-Random Noise Radar Transceiver With a Programmable Sequence Generator in SiGe Technology

This paper describes a fully-integrated 77-GHz ultra-wideband pseudo-random noise (PRN) radar transceiver in a Silicon-Germanium technology. The transceiver is equipped with a programmable pseudo-random binary sequence (PRBS) generator, which is realized in a current-mode logic topology and can be operated with a clock rate of up to 4.25 GHz to enable a range resolution of 3.5 cm. The signal generation unit is simplified by including a frequency multiplier to create a 76.5-GHz carrier signal from a single 4.25-GHz input, that is also used as a clock for the PRBS generator. The transceiver achieves a phase noise of -105.3 dBc/Hz at 1-MHz offset frequency, a transmit output power of 6.2 dBm, a receive gain of 24 dB and an input-referred 1-dB compression point of -14 dBm. Track&hold circuits included in the receive path allow the use of a sub-sampling technique to reduce the IF data rate down to 1 MHz. Radar measurements with two PRN transceivers with different primitive polynomials were done concurrently to show a fundamental function of the programmable PRBS generator. Radar measurements with the PRN and the frequency-modulated continuous-wave (FMCW) principles show comparable results and the PRN radar proves to be a real alternative to the FMCW radar.
Effect of urea supplementation on performance and safety in diets of Dorper crossbred sheep.

This study was conducted to evaluate the efficacy and safety of dietary urea in sheep rations having a 50:50 concentrate:roughage ratio. Sixty-four Dorper × thin-tailed Han crossbred ram lambs with an average body weight of 30.8 (±0.02) kg were randomly divided into four groups of 16 sheep each, and each group was fed one of the following diets: a basal diet (CON), or CON supplemented with 0.5% (0.5UTM), 1.5% (1.5UTM) or 2.5% (2.5UTM) urea. Growth performance, carcass characteristics, non-carcass offals, meat quality and peptic tissue lesions were assayed. The average daily weight gains for CON, 0.5UTM, 1.5UTM and 2.5UTM were 216, 218, 200 and 170 g, respectively, with the CON and 0.5UTM groups higher than 2.5UTM group (p < 0.05). Sheep from the 2.5UTM treatment had a significantly lower dry matter intake (1.29 kg/day) than those from the CON and 0.5UTM treatments (1.42 and 1.43 kg/day, p < 0.05), and the feed conversion ratio in the 2.5UTM group was the highest (p < 0.05). Carcass characteristics, including shrunk body weight, empty body weight, hot carcass weight, dress percentage, and the absolute or relative weight (% body weight) of heart, liver, spleen, lung and kidney, were not altered by the treatments (p > 0.05). The muscular pH of 2.5UTM was higher than that of CON (5.68 vs. 5.52, p < 0.05), and shear force in 0.5UTM was lower compared with CON and 2.5UTM (p < 0.05). The anatomical structure lesions in kidneys became more serious with the increasing dietary urea concentrations, with the 2.5UTM animals showing the most severe lesions compared with CON animals. Therefore, supplementary urea as a non-protein nitrogen source for sheep should not exceed 1.5% of ration having a 50:50 concentrate:roughage ratio to ensure efficacy and safety.
Effects of Atrial Natriuretic Peptide on Hemodynamics , Neurohormonal Factors and Inflammatory Cytokines in Patients with Compensated Heart Failure Due to Idiopathic Dilated Cardiomyopathy

Background: A recombinant human atrial natriuretic peptide (ANP) has been reported to have multiple cardiovascular effects such as diuresis, vasodilation, and suppression of neurohormonal activity. However, few clinical investigations exist for the immune-modulating effects of ANP. Thus, we investigated if ANP modulates inflammatory cytokines as well as hemodynamics and neurohormonal factors in patients with compensated heart failure (CHF) due to idiopathic dilated cardiomyopathy (DCM). Methods: Sixty DCM patients were recruited and divided randomly into two groups, the placebo group and the ANP group. In the ANP group, blood sampling for the measurements of norepinephrine (NE), brain natriuretic peptide (BNP), rennin (PRA), aldosterone (PAC), tumor necrosis factor-alpha (TNF-a), interleukin-6 (IL-6) and interleukin-10 (IL-10) and tissue Doppler echocardiography were performed five days before and just before continuous infusion of ANP for 96 hours and immediately and seven days after termination. Results: ANP significantly improved left ventricular filling and decreased BNP, NE, PAC and TNF-a, IL-6 levels, whereas significantly increased IL-10 levels from 0.78 ± 0.05 pg/ml to 8.63 ± 0.64 pg/ml (p < 0.001). In ANP group, both TNF-a/IL-10 and IL-6/IL-10 decreased from 57.03 ± 4.76 to 3.41 ± 0.46 (p < 0.001) and from 6.72 ± 0.63 to 0.23 ± 0.03 (p < 0.001), respectively and these effects remained unchanged for seven days after termination. Conclusion: ANP improved an imbalance in the cytokine network as well as hemodynamics and neurohormonal factors of CHF due to DCM.
MEMS Gyroscopes Based on Piezoresistive NEMS Detection of Drive and Sense Motion

This paper presents yaw and pitch micro-electromechanical system gyroscopes embedding four active nanoelectromechanical (NEMS) piezoresistive gauges each, two of which are used for differential sensing of the Coriolis motion, and two of which are innovatively used to sense the drive motion and thus to close the drive oscillation loop. After presenting the devices design, this paper discusses the advantages of this particular implementation in terms of operating voltages, electrical equivalent model, and temperature behavior of the scale factor. In operation with voltages lower than 1.8 V without voltage boosting, the devices show sub mdps/ $\surd {\rm Hz}$ noise density within areas of about 1 mm2 per device at 0.2-mbar package pressure. Under temperature sweeps, a 3.7-fold better immunity of the scale factor stability is obtained, compared with a similar gyroscope embedding combs (and not NEMS) for drive detection. [2017-0050]
Tissue Plasminogen Activator for Acute Ischemic Stroke in Clinical Practice: A Meta-Analysis of Safety Data

Background and Purpose— Concerns persist regarding the safety of tissue plasminogen activator (tPA) therapy for acute ischemic stroke. Numerous case series of clinical experience with tPA have been published that provide additional data on the safety of thrombolytic therapy. Methods— This is a meta-analysis of 15 published, open-label studies that broadly followed approved indications and guidelines for tPA use in nonselective patient populations. Results— In 2639 treated patients, the symptomatic intracerebral hemorrhage rate was 5.2% (95% confidence interval, 4.3 to 6.0), slightly lower than the 6.4% rate in the treated group of the randomized, placebo-controlled National Institute of Neurological Disorders and Stroke (NINDS) trial. The mean total death rate (13.4%) and proportion of subjects achieving a very favorable outcome (37.1%) were comparable to the NINDS trial results. Protocol deviations were reported in 19.8%. Comparing across studies showed that the mortality rate was correlated with the percentage of protocol violations (r =0.67, P =0.018). Conclusions— Postapproval data support the safety of intravenous thrombolytic therapy with tPA for acute ischemic stroke, especially when established treatment guidelines are followed.
Detection of classical Hodgkin lymphoma specific sequence in peripheral blood using a next‐generation sequencing approach

We applied a highly sensitive next‐generation sequencing method to identify lymphoma‐specific immunoglobulin gene segments in classical Hodgkin lymphoma (CHL) at initial diagnosis or recurrence, and assessed the ability of detecting such lymphoma‐specific sequences in peripheral blood (PB). Seventeen CHL cases were tested and lymphoma‐specific sequences were identified in 12 of the primary tumour biopsies. In 11 of these patients whose paired PB samples were available, tumour‐specific clonotypes were detected in PB in eight patients. This data demonstrates the feasibility of detecting circulating tumour‐specific sequences, creating an unprecedented opportunity to optimize the future treatment and monitoring strategies for patients with CHL.
Peripheral Vascular Obstruction in Rheumatoid Arthritis and its Relationship to other Vascular Lesions

Gangrene of the terminal portions of the limbs may be due to obstruction in the peripheral vessels, large or small, or it may be associated with cardiac failure as in rheumatic or ischaemic heart disease (Swan and Henderson, 1951), with ball valve thrombi, or with pulmonary disease (Boulet, Serre, Vedel, Vallat, and Mirouze, 1949; Hejtmancik and Bruce, 1953). In a case of mitral stenosis and gangrene of the limbs and nose, in which I dissected the finger vessels and studied them in detail, no pathological changes were seen: the process had been thought to be one of low output and vasospasm. Obstruction peripherally may be due to primary changes in the blood, as in cryoglobulinaemia (Myerson and Stout, 1955), or to cold agglutination (Stats and Bullowa, 1943), but is more usually due to primary vessel disease, as in polyarteritis nodosa (Taylor and Jacoby, 1949), Buerger's disease, giant cell, or temporal arteritis (Chasnoff and Vorzimer, 1944), to multiple embolization, or to vasospasm, as in Raynaud's disease or crutch arteritis (Stammers, 1954). In scleroderma it seems possible that vessel changes precede the skin sclerosis. Occasionally, however, an unusual type of peripheral arterial obstruction has been found which does not fit easily into any of the above categories (Whiteley and Wilson, 1952). It is the object of this study to describe such clinical and pathological changes occurring in the course of rheumatoid arthritis, and to discuss the relationship of these changes to those found in generalized lupus erythematosus, to the better-defined entities listed briefly above, and to the rarer ill-defined group of published cases not easily accommodated within these diagnostic pigeonholes. Some years ago an account was published of six patients whose early clinical course resembled palindromic rheumatism, but who later showed clinical and radiological signs of rheumatoid arthritis and, in addition, some other curious features, notably cutaneous nodules (Bywaters, 1949). One of these patients (Case 2) later died with gangrene of all four limbs. The present study describes the progress and terminal stages of this case, together with nine other examples of peripheral vascular obstruction (Table, opposite).
A randomized, double‐blind, placebo controlled, multi‐center study of intravenous iron sucrose and placebo in the treatment of restless legs syndrome

Iron deficiency may exacerbate symptoms in the Restless Legs Syndrome (RLS). We investigated the effect of intravenous iron sucrose or placebo on symptoms in patients with RLS and mild to moderate iron deficit. Sixty patients with primary RLS (seven males, age 46 (9) years, S‐ferritin ≤45 μg/L) recruited from a cohort of 231 patients were randomly assigned in a 12‐months double‐blind, multi‐centre study of iron sucrose 1000 mg (n = 29) or saline (n = 31). The primary efficacy variable was the RLS severity scale (IRLS) score at week 11. Median IRLS score decreased from 24 to 7 (week 11) after iron sucrose and from 26 to 17 after placebo (P = 0.123, N.S. for between treatment comparison). The corresponding scores at week 7 were 12 and 20 in the two groups (P = 0.017). Drop out rate because of lack of efficacy at 12 months was 19/31 after placebo and 5/29 patients after iron sucrose (Kaplan–Meier estimate, log rank test P = 0.0006) suggesting an iron induced superior long term RLS symptom control. Iron sucrose was well tolerated. This study showed a lack of superiority of iron sucrose at 11 weeks but found evidence that iron sucrose reduced RLS symptoms both in the acute phase (7 weeks) and during long‐term follow up in patients with variable degree of iron deficiency. Further studies on target patient groups, dosing and dosing intervals are warranted before iron sucrose could be considered for treatment of iron deficient patients with RLS. © 2009 Movement Disorder Society
Epidemiology of alcohol abuse in military and civilian populations.

Results from a random sample survey of US Air Force personnel show that 4.6 per cent exhibit alcohol dependence, indicated by symptoms of withdrawal and impaired control over drinking. An additional 9.3 per cent can be identified as nondependent alcohol abusers, indicated by serious adverse effects of drinking (such as arrest, accident, hospitalization, or significant work impairment) or by heavy alcohol consumption (over 150 ml of ethanol daily). Compared with data from supervisors and official records, survey results did not understate alcohol-related problems. Survey reports of alcohol consumption did underestimate alcoholic beverage sales by about 20 per cent, but adjustments for this discrepancy increased the prevalence rate by less than one percentage point. Rates of serious alcohol abuse among representative samples of males in the U.S. Army, Navy, Air Force, and civilian populations were also compared. Although the rates were higher in the military than among civilians, most of the difference was associated with the higher-risk demographic characteristics of military personnel, who are more likely than civilians to be young unmarried males. Results indicate that the rate of alcohol abuse in the military is about the same as in civilian groups with comparable demographic characteristics.
Update on acute liver failure

Purpose of reviewAlthough advances in critical care management and liver transplantation have improved survival in acute liver failure (ALF), mortality remains significant. An evidence base to support management has been lacking, due to the condition's rarity, severity and heterogeneity. The purpose of this review is to critically appraise the latest evidence, updating clinicians on the current understanding of the best management. Recent findingsTransplant-free survival in acetaminophen-related ALF has improved considerably, such that reconsidering thresholds for transplant is required, perhaps utilizing biomarkers of liver regeneration. Autoimmune hepatitis-related ALF may be too advanced to permit rescue with corticosteroids, which could be deleterious in the sickest patients. Acute kidney injury is commoner in ALF than previously suspected. Intracranial pressure monitoring does not appear to alter mortality. Despite altered traditional indices of coagulation, new thrombin generation assays suggest a rebalanced coagulation in liver failure. Antimicrobial prophylaxis may not be required in all patients. Liver support systems remain controversial and require further evaluation. SummaryTraditional dogma in ALF management is questioned: transplant thresholds for acetaminophen overdose, steroid use in autoimmune ALF, routine antimicrobial prophylaxis, the coagulopathy of liver disease, the value of intracranial pressure monitoring and extracorporeal liver support.
Acorn removal and dispersal by the dung beetle Thorectes lusitanicus: ecological implications

Abstract 1. Plant–animal interactions, and in particular the processes of seed predation and dispersal, are crucial for tree regeneration and forest dynamics. A novel and striking case of interaction between a dung beetle (Thorectes lusitanicus) and two Quercus species (Q. suber and Q. canariensis) in forests of southern Spain is presented here.
ANIMAL MODELS FOR THE EFFECT OF AGE ON SUSCEPTIBILITY TO INHALED PARTICULATE MATTER

Epidemiological findings of associations between ambient particulate matter (PM) and respiratory and cardiovascular mortality and morbidity have fostered increased laboratory research aimed at understanding the key PM components, mechanisms, and doseresponse relationships responsible for the effects. Because the health impacts are largely observed in subpopulations having characteristics known or presumed to confer increased susceptibility to PM, there is a need for identifying, developing, and using animal models of these susceptibility factors. Age, during both development and senescence of the cardiorespiratory system and its defenses, is one of the PM susceptibility factors cited frequently. This review is intended as a summary of current knowledge regarding age-related differences in the structure and function of the respiratory and pulmonary vascular systems of humans and animals. Its purpose is to facilitate the selection of appropriate animal models for research on the various facets of potential agerelated susceptibility of the human respiratory tract to the effects of inhaled PM. The selection of models is a difficult challenge because no single animal species adequately models the full range of human respiratory anatomy, physiology, and age-related changes. With careful selection among the many species, strains, and comparative ages, however, animals can be selected to model most, if not all, of the individual factors hypothesized to confer increased susceptibility of humans to inhaled PM. The existing information does not provide an adequate basis for selecting models to test all of the current age-related susceptibility hypotheses. However, the information summarized in this report should facilitate the investigator's review of potential models.
Bio equivalence Study of Two Different Film-coated Tablet Formulations of Losartan-Hydrochlorothiazide in Healthy Volunteers

Abstract The study was conducted in order to assess the bioequivalence of two film-coated formulations containing 100 mg of losartan (CAS 124750-99-8) and 12.5 mg of hydrochlorothiazide (CAS 58-93-5). Seventy-three healthy subjects were enrolled in arandomised, single-dose, open-label, two-way crossover study, with a minimum washout period of 7 days. A total of 21 blood samples were collected up to 36 h post-dosing. Losartan, losartan carboxy acid and hydrochlorothiazide levels were determined by liquid chromatography with tandem mass detection (lower limit of quantification: 1.01 ng/mL for hydrochlorothiazide, 2.02 ng/mL for losartan and 2.51 ng/mL for losartan carboxy acid). Pharmacokinetic parameters used for bioequivalence assessment (AUC0–t and Cmax as primary and AUC0–inf as secondary pharmacokinetic parameters) were determined from the losartan and hydrochlorothiazide concentration data using non-compartmental analysis. Data from losartan carboxy acid was reported and presented as supportive data. The 90% confidence intervals (obtained by ANOVA) for losartan were 97.05–118.48% for Cmax, 100.76–106.10% for AUC0–t and 100.80–106.10% for AUC0–inf whereas for hydrochlorothiazide the 90% confidence intervals obtained were 103.94–115.33% for Cmax 101.97–109.61% for AUC0–t and 101.77–109.02% for AUC0–inf, and for losartan carboxy acid the intervals obtained were 98.31–107.82% for Cmax, 97.89–104.30% for AUC0–t and 98.06–104.30% for AUC0–inf. All the 90% confidence intervals obtained for all the parameters assessed were within the predefined ranges (80–125%). Based on these results, it can be concluded that the evaluated formulations are bioequivalent in terms of rate and extent of absorption.
A Distributed, Multi-Agent Approach to Reactive Network Resilience

Critical network infrastructures are communication networks whose disruption can create a severe impact on other systems. Multi-agent systems have been successfully used to protect critical network infrastructures, with approaches ranging from reasoning about secure design and policies to multi-agent intrusion detection systems (IDS). However, there is little research on the possibilities for multi-agent systems to react to known intrusions. In this paper we propose a multi-agent framework for reactive network resilience, that is, to allow a network to reconfigure itself in the event of a security incident so that the risk of further damage is mitigated. The proposed framework takes advantage of a risk model based on multilayer networks and of distributed belief propagation techniques to agree on a new, more resilient configuration of the network in the event of an attack. We compare our proposal with a number of centralized optimization and multi-agent negotiation techniques. Experiments show that our proposal outperforms the reference approaches both in terms of risk mitigation and performance
The Heterogeneity of New Daily Persistent Headache

CLINICAL HISTORIES Case 1. —This is a 42-year-old woman who developed a right nuchal-occipital throbbing and vice-like headache with an intensity of 10/10 at the onset while sitting with nausea, vomiting, and a spinning sensation but no hearing loss, pressure in the ears, tinnitus, or other neurological symptoms 5 months previously. The headache had an intensity of 10/10 for about 3 weeks. Since then, she has had a constant headache described as a right nuchal-occipital and right hemicranial aching, throbbing, and stabbing with an intensity ranging from 4 to 8/10, with an average of 3-5/10 with nausea at times, and light and noise sensitivity, but no vomiting, visual symptoms, or vertigo since the first day. She had intermittent true vertigo lasting up to 30 minutes initially on a daily basis that did not totally resolve for about 6 weeks. She was taking baclofen 10 mg in the morning and 20 mg at bedtime that decreased the pain. She tried eletriptan 40 mg that dulled the pain. Three years previously, she had a mild head injury resulting in headaches for 3 weeks following but no other history of headaches. There was a past medical history of asthma. She initially saw her primary care physician who prescribed oral ketorolac and promethazine without benefit. A computed tomography (CT) scan of the brain without contrast 4 days after onset was negative. She then saw a neurologist who placed her on topiramate that was titrated up to 200 mg daily with mild benefit.A complete blood count, comprehensive metabolic panel, thyroid function tests, erythrocyte sedimentation rate (ESR), antinuclear antibody, and magnetic resonance imaging (MRI) and magnetic resonance angiogram (MRA) scans of the brain were normal. She had a normal evaluation by an otorhinolaryngologist including an audiogram and electronystagmogram. I saw her in headache consultation 4 weeks after onset. A neurological examination and an MRA of the brain and neck, MRV of the brain, and MRI of the brain with and without contrast were normal. Topiramate was increased to 300 mg daily that mildly decreased the intensity of the pain, allowing her to work. Although consideration was given to a trial of From the Montefiore Headache Center, Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA (M.S. Robbins); Baylor College of Medicine, Houston, TX, USA (R.W. Evans).
An evaluation of tetramethylbenzidine as a presumptive test for blood.

In forensic use, a presumptive test indicating the possible presence of blood is an invaluable tool. This type of test has particular value in screening out samples that are definitely not blood and do not require further testing. Used in this manner, a test should be sensitive to some component of blood which remains even after the blood has dried, aged, or become diluted. This ideal test should also be specific. No such ideal specific test actually exists; however, the tests that are currently used have been characterized, and remedies for nonspecific reactions have been devised [1]. Since a presumptive test is used for screening, it should be simple to use and provide rapid results. Any test should be safe for the examiner applying it.