Miracle-dz/UniFAR-FTUs huggingface dataset:
Information, knowledge creation and innovation management in sport: an introduction to the thematic section

in sport: an introduction to the thematic section Vassil Girginov, Kristine Toohey and Annick Willem Department of Life Sciences, Brunel University, London, UK; Visitng Professor, University of Johannesburg, Republic of South Africa; Department of Tourism, Sport and Hotel Management, Griffith University, Gold Coast, Australia; Department of Movement and Sports Sciences, University of Ghent, Ghent, Belgium
Mixture design for food packaging in a modified atmosphere

There has been significant development in active packaging systems over the past 20 years. Some packaging concepts belonging to this category were used previously, but in the last two decades, there has been systematic research. Two types of packaging systems with interactive functions are currently distinguished, as described below. Intelligent packaging is used to monitor conditions in the surroundings of the packaged product, and thus provides information about the quality of the packed food during transportation and storage. Temperature indicators and indicators of internal composition of the atmosphere are currently commercially available, along with indicators for the measurement of freshness of the packaged product. A new category of intelligent packaging systems uses elements based on radio-frequency identification (RFID) technology.
Void probability as a function of the void's shape and scale-invariant models. [in studies of spacial galactic distribution]

The dependence of counts in cells on the shape of the cell for the large scale galaxy distribution is studied. A very concrete prediction can be done concerning the void distribution for scale invariant models. The prediction is tested on a sample of the CfA catalog, and good agreement is found. It is observed that the probability of a cell to be occupied is bigger for some elongated cells. A phenomenological scale invariant model for the observed distribution of the counts in cells, an extension of the negative binomial distribution, is presented in order to illustrate how this dependence can be quantitatively determined. An original, intuitive derivation of this model is presented.
The Application of Hilbert-Huang Transforms to Meteorological Datasets

Abstract Recently a new spectral technique has been developed for the analysis of aperiodic signals from nonlinear systems—the Hilbert–Huang transform. It is shown how this transform can be used to discover synoptic and climatic features: For sea level data, the transforms capture the oceanic tides as well as variations in precipitation patterns. In the case of solar radiation, variations in the diurnal and seasonal cycles are observed. Finally, from barographic data, the Hilbert–Huang transform reveals the passage of extratropical cyclones, fronts, and troughs. Thus, this technique can detect signals on synoptic to interannual time scales.
ANXA2 Silencing Inhibits Proliferation, Invasion, and Migration in Gastric Cancer Cells

Annexin A2 (ANXA2) has been well known to associate with the progress of malignant tumor. However, the biological behavior of ANXA2 in gastric cancer (GC) remains unclear. We made a hypothesis in transcriptome level from TCGA datasets. Then, we used immunohistochemical staining to quantify the expression level of ANXA2 protein in GC tissues compared with adjacent tissues. Quantitative real-time PCR and western blot were used for analyzing ANXA2 expression in human GC (SGC-7901, MKN-45, BGC-823, and AGS) cell lines. We investigated the effect of a lentivirus-mediated knock-down of ANXA2 on the proliferation, invasion and migration of gastric cancer AGS cells. Cell proliferation was examined by MTT and colony formation tests. Cell apoptosis and cycle were measured by flow cytometry. Migration and invasion were detected by transwell assay. We found that high expression of ANXA2 can increase the mobility of cancer cells from TCGA datasets. ANXA2 was upregulated in GC tissues compared with adjacent tissues. AGS cell line displayed significantly higher expression of ANXA2 among the four GC cell lines. In addition, ANXA2 silencing led to a weakened ability of proliferation, invasion, and migration in GC cells; targeting of ANXA2 may be a potential therapeutic strategy for GC patients.
A novel zinc finger gene, ZNF465, is inappropriately expressed in acute myeloid leukaemia cells

To increase our knowledge of leukaemia‐associated antigens, especially in acute myeloid leukaemia (AML) M4, we prepared a phage display cDNA library using mRNA from the bone marrow cells of a patient with AML M4 at diagnosis. We immunoscreened 106 pfu with autologous sera and identified an antigen which we named GKT‐AML8. The cDNA showed more than 99% similarity to a sequence on 2q21.2 and 95% sequence similarity to a sequence on 19q13.3. These genes were named ZNF465 and ZNF466, respectively, following HUGO Gene Nomenclature Committee (HGNC) guidelines. Expressed sequence tag data suggests that both genes are transcriptionally active. ZNF465 and ZNF466 encode a 5′ krüppel associated box domain typical of negative regulators of gene transcription. We have confirmed the translational start site in the +1 frame in a near‐Kozak sequence that produces a 102 amino acid polypeptide from ZNF465. The high level of sequence similarity between ZNF465 and ZNF466 makes their transcripts almost indistinguishable by real‐time polymerase chain reaction (RT‐PCR). However, GKT‐AML8 showed most sequence similarity to ZNF465 and no transcript matching the 3′ ZNF466 sequence could be detected in patient samples or healthy volunteers. ZNF465/466 expression was detectable in 12/13 AML and 10/14 chronic myeloid leukaemia patients' samples but not in normal donor peripheral blood (0/8) or 0/3 bone marrow samples which had been separated into CD34+ and CD34− samples. The altered expression of ZNF465/466 in patients' samples and its absence in healthy donor haematopoietic samples indicate that ZNF465 is overexpressed in early myeloid disease and as such may represent a promising target for immunotherapy. © 2015 Wiley Periodicals, Inc.
Reinstating the Resourceful Self: When and How Self-Affirmations Improve Executive Performance of the Powerless

Research has found that lack of power impairs executive functions. In the present research, we show that this impairment is not immutable. Across three studies and focusing on inhibitory control as one of the core facets of executive functions, our investigation shows that self-affirmation attenuates the previously documented decrements in inhibitory control of the powerless (Studies 1-3). We also examine boundary conditions of this effect and demonstrate that self-affirmation is most effective insofar as the powerless lack self-esteem (Study 2). Finally, we directly test the underlying process of this effect and demonstrate that self-affirmation increases an efficacious self-view among the powerless, which in turn improves their inhibitory control abilities (Study 3). Overall, we conclude that reinstating an efficacious self-view through self-affirmation offsets the impairments in inhibitory control abilities of the powerless and reduces the cognitive performance gap between the powerless and the powerful.
Inhibition of Insulin Degrading Enzyme and Insulin Degradation by UV-Killed Lactobacillus acidophilus

Probiotics have beneficial effects on management of type 2 diabetes (T2D). The major hallmarks of T2D are insulin deficiency and insulin resistance which emphasize insulin therapy in onset of disease. Lactobacilli such as Lactobacillus acidophilus (L. acidophilus) have well known properties on prevention of T2D and insulin resistance but not on insulin degradation. Insulin-degrading enzyme (IDE) degrades insulin in the human body. We studied the effects of cell-free supernatant (CFS) and ultraviolet (UV)-killed L. acidophilus (ATCC 314) on IDE activity and insulin degradation in vitro. Cell growth inhibition by CFS and UV-killed L. acidophilus (ATCC 314) was studied and Western blotting and a fluoregenic assay was performed to determine IDE expression and its activity, respectively. Insulin degradation was evaluated by sandwich enzyme-linked immunosorbent assay(ELISA). IDE expression and activity was reduced by CFS and UV-killed L. acidophilus (ATCC 314). Although, decreased enzyme expression and activity was not significant for CFS in contrast to MRL (MRS with same pH as CFS). Also, reduction in IDE activity was not statistically considerable when compared to IDE expression. Insulin degradation was increased by CFS but decreased by UV-killed L. acidophilus (ATCC 314).
Hyperscaling at the spin density wave quantum critical point in two-dimensional metals

The hyperscaling property implies that spatially isotropic critical quantum states in $d$ spatial dimensions have a specific heat which scales with temperature as $T^{d/z}$, and an optical conductivity which scales with frequency as $\omega^{(d-2)/z}$ for $\omega \gg T$, where $z$ is the dynamic critical exponent. We examine the spin-density-wave critical fixed point of metals in $d=2$ found by Sur and Lee (Phys. Rev. B 91, 125136 (2015)) in an expansion in $\epsilon = 3-d$. We find that the contributions of the "hot spots" on the Fermi surface to the optical conductivity and specific heat obey hyperscaling (up to logarithms), and agree with the results of the large $N$ analysis of the optical conductivity by Hartnoll et al. (Phys. Rev. B 84, 125115 (2011)). With a small bare velocity of the boson associated with the spin density wave order, there is an intermediate energy regime where hyperscaling is violated with $d \rightarrow d_t$, where $d_t = 1$ is the number of dimensions transverse to the Fermi surface. We also present a Boltzmann equation analysis which indicates that the hot spot contribution to the DC conductivity has the same scaling as the optical conductivity, with $T$ replacing $\omega$.
Winery Tasting-Room Employee Training: Putting Wine First in Oregon

ABSTRACT Oregon wineries have become increasingly reliant on tasting-room employees to increase wine distribution. Properly training tasting-room employees is essential to increasing sales of wine at wineries. In this study, the researchers explore the methods, techniques, and practices employed to train Oregon tasting-room employees. The results indicate managers perceive product knowledge as the most common form of training needed for tasting-room employees to succeed. Sales incentives were not consistent in the findings of the training programs. Three out of every four managers responded that job shadowing was the most popular form of training in their tasting rooms.
Identification of endothelial selectin as a potential prognostic marker in breast cancer

Endothelial selectin (ELAM1 or CD62E) has been previously reported as being associated with the prognosis of multiple types of cancer. However, its prognostic value in breast cancer (BC) remains unclear. The aim of the present study was to investigate the prognostic value of ELAM1 mRNA expression in BC tissue. The prognostic value of ELAM1 mRNA was assessed in patients with BC using the Kaplan-Meier plotter (KM-plot) database. The KM-plot generated updated ELAM1 mRNA expression data and survival analysis from a total of 3,951 patients with BC, gathered from 35 datasets. Low expression of ELAM1 mRNA was correlated with a poorer overall survival in 1,402 patients with BC followed for 20 years [hazard ratio (HR), 0.71; 95% confidence interval (CI), 0.57–0.88; log-rank P=0.0016]. Low expression of ELAM1 was also correlated with poorer relapse-free survival (HR, 0.69; 95% CI, 0.62–0.77; log-rank P=2.2e-11) in 3,951 patients and poorer distant metastasis-free survival (HR, 0.79; 95% CI, 0.65–0.96; log-rank P=0.02) in 1,746 patients with BC followed for 20 years. Results from the Metabolic gEne RApid visualizer database indicated that ELAM1 mRNA expression was elevated in normal tissue. The results of the present study suggest that ELAM1 mRNA is a potential prognostic and metastatic marker in patients with BC.
Romosozumab FRAME Study: A Post Hoc Analysis of the Role of Regional Background Fracture Risk on Nonvertebral Fracture Outcome

In the pivotal Fracture Study in Postmenopausal Women with Osteoporosis (FRAME; NCT01575834), 1 year of the bone‐forming agent romosozumab significantly reduced new vertebral and clinical fracture risk versus placebo. Nonvertebral fracture risk was not significantly reduced in the overall population, influenced by a low placebo‐group fracture rate, observed particularly in the highest‐enrolling region of Latin America. In year 1 of FRAME, postmenopausal women with a T‐score of –2.5 to –3.5 at the total hip or femoral neck were randomized to subcutaneous romosozumab 210 mg or placebo once monthly for 12 months. Of 7180 randomized women, 43% were from Latin America, largely Colombia and Brazil. Prespecified analyses assessed fracture risk reductions by geographic regions. A significant treatment‐by‐geographic region interaction for the clinical (p = 0.029) and nonvertebral fracture (p = 0.042) endpoints led to further characterization of the Latin American population and comparison with the remaining study population, grouped post hoc as rest‐of‐world. Nonvertebral fracture efficacy in the overall population was also assessed by baseline fracture risk using the Fracture Risk Assessment Tool (FRAX). Romosozumab significantly and consistently reduced new vertebral fracture risk in Latin America (70% reduction; p = 0.014) and rest‐of‐world (74% reduction; p < 0.001). For nonvertebral fracture, risk reductions were observed in rest‐of‐world (42% reduction; p = 0.012), with no treatment effect observed in Latin America, where background nonvertebral fracture risk was low (1.2% in the placebo group). Consistent with this finding, in the overall population, greater reductions in nonvertebral fracture risk were observed among women with higher FRAX scores. These findings suggest that fracture risk assessment should consider regional factors in addition to classical risk factors, such as bone mineral density. In women at high risk for fracture, romosozumab reduced nonvertebral fracture risk within 1 year. © 2018 The Authors. Journal of Bone and Mineral Research Published by Wiley Periodicals, Inc.
Discordance in ERα, PR and HER2 receptor status across different distant breast cancer metastases within the same patient.

BACKGROUND We studied discordance in estrogen receptor alpha (ERα), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) status between multiple distant metastases from the same breast cancer patient. MATERIAL AND METHODS Multiple distant metastases from 55 female patients were stained for ERα, PR and HER2 by immunohistochemistry and in situ hybridization for confirmation of the HER2 status. RESULTS Different metastatic sites within the same patient showed discordance in ERα receptor status in 7.3% or 10.9% of patients (using a 10% or 1% threshold for positivity, respectively). For PR, 29.1% or 30.9% of patients showed discordance. Taking ERα and PR together, 36.4% of cases (both thresholds) showed discrepancy between metastases. In 10.9% (10% threshold) or 14.5% of patients (1% threshold), such discordance could have clinical consequences with regard to hormonal treatment. For HER2, there was 3.6% discordance on the immunohistochemical level but 0% on the gene level. CONCLUSION In a significant proportion of metastatic breast cancer patients, discordance in ERα and PR receptor status between different metastatic sites was observed. This implies that multiple metastases may need to be biopsied to optimally reassess receptors.
Analyzing the potential of source sentence reordering in statistical machine translation

We analyze the performance of source sentence reordering, a common reordering approach, using oracle experiments on German-English and English-German translation. First, we show that the potential of this approach is very promising. Compared to a monotone translation, the optimally reordered source sentence leads to improvements of up to 4.6 and 6.2 BLEU points, depending on the language. Furthermore, we perform a detailed evaluation of the different aspects of the approach. We analyze the impact of the restriction of the search space by reordering lattices and we can show that us-ing more complex rule types for reordering results in better approximation of the optimally reordered source. However, a gap of about 3 to 3.8 BLEU points remains, presenting a promising perspective for research on extending the search space through better reordering rules. When evaluating the ranking of different reordering variants, the results reveal that the search for the best path in the lattice performs very well for German-English translation. For English-German translation there is potential for an improvement of up to 1.4 BLEU points through a better ranking of the different reordering possibilities in the reordering lattice.
Abnormal gait pattern emerges during curved trajectories in high-functioning Parkinsonian patients walking in line at normal speed

Background Several patients with Parkinson´s disease (PD) can walk normally along straight trajectories, and impairment in their stride length and cadence may not be easily discernible. Do obvious abnormalities occur in these high-functioning patients when more challenging trajectories are travelled, such as circular paths, which normally implicate a graded modulation in the duration of the interlimb gait cycle phases? Methods We compared a cohort of well-treated mildly to moderately affected PD patients to a group of age-matched healthy subjects (HS), by deliberately including HS spontaneously walking at the same speed of the patients with PD. All participants performed, in random order: linear and circular walking (clockwise and counter-clockwise) at self-selected speed. By means of pressure-sensitive insoles, we recorded walking speed, cadence, duration of single support, double support, swing phase, and stride time. Stride length-cadence relationships were built for linear and curved walking. Stride-to-stride variability of temporal gait parameters was also estimated. Results Walking speed, cadence or stride length were not different between PD and HS during linear walking. Speed, cadence and stride length diminished during curved walking in both groups, stride length more in PD than HS. In PD compared to HS, the stride length-cadence relationship was altered during curved walking. Duration of the double-support phase was also increased during curved walking, as was variability of the single support, swing phase and double support phase. Conclusion The spatio-temporal gait pattern and variability are significantly modified in well-treated, high-functioning patients with PD walking along circular trajectories, even when they exhibit no changes in speed in straight-line walking. The increased variability of the gait phases during curved walking is an identifying characteristic of PD. We discuss our findings in term of interplay between control of balance and of locomotor progression: the former is challenged by curved trajectories even in high-functioning patients, while the latter may not be critically affected.
Unpacking experience effects in developing novel products for new markets

A key process for exploration is to develop products in order to serve new markets. An implicit assumption in the organizational learning literature, not yet tested empirically, is that the increasing breadth of knowledge and experience firms gain by expanding into new product markets (i.e. exploration experience) may enhance their capacity to innovate in the future. We address how firms may find it more challenging to learn from their exploration experience when they develop new technology instead of employing their existing technology to create new products. In our theory and analyses, we address endogeneity by accounting for the behavioral learning process that leads managers to explore new markets following periods of poor firm performance. We test our model using fine-grained data on new product development projects initiated by 52 biopharmaceutical firms between 1979 and 2000 and find empirical support. Our study identifies a theoretical boundary condition on the relationship between exploration experience in new product markets and subsequent performance in developing novel products.
The role of markets in the construction of wellbeing: The need for a Polanyian perspective

Recent research on subjective wellbeing (SWB) has demonstrated the prime importance of social factors such as relationships with family and friends alongside income and work. While it has offered a new route to measuring utility for economists, SWB has revealed “puzzles and paradoxes” in relating it to income. Wellbeing is an holistic concept which seeks to engage with understanding people’s lives as they are lived in society. But the analytical boundaries between the social sciences thwart such an enquiry. After reviewing key findings on work and income for their connection to social dimensions, this paper reviews writings of key contributors to the SWB literature – Layard and Sen – and traces the problem to the use of the analytical concept of the self-regulating market. Polanyi’s The Great Transformation argues that the idea of the market as a self-regulating mechanism itself drove the promotion of a laissez-faire economy, so becoming detached from society. Polanyi contends that the concept of the market has itself to be re-embedded in wider society if we are to understand the means through which provisioning of needs takes place. Polanyi’s concept of the institutedness of the economy through reciprocity and redistribution as well as exchange provides a useful starting point for this investigation.
Breath-powered sumatriptan dry nasal powder: an intranasal medication delivery system for acute treatment of migraine

There is a need for fast-acting, non-oral medication options for migraine because some attacks develop rapidly and some are accompanied by nausea, vomiting, and gastroparesis, which can hinder oral medication uptake and absorption. The most commonly prescribed migraine medications are oral triptans, with sumatriptan as the most common. However, oral triptans are associated with adverse events (AEs) of atypical sensations that may be problematic for patients. Subcutaneous (SC) injectable sumatriptan and conventional liquid triptan nasal spray formulations are also available, but the frequency of atypical sensations is the highest with SC sumatriptan, and the intense bitter taste of conventional liquid triptan nasal spray discourages use. AVP-825 (ONZETRA® Xsail®) is an intranasal medication delivery system containing 22 mg sumatriptan nasal powder that is now available in the USA for the acute treatment of migraine with or without aura in adults. The objective of this review is to summarize the development of AVP-825, which utilizes unique features of nasal anatomy to achieve efficient absorption and reduced systemic exposure. Literature searches for “sumatriptan nasal powder”, “AVP-825”, and “sumatriptan intranasal” were conducted. Review articles and pharmacokinetic, Phase II and Phase III studies were evaluated. AVP-825 demonstrates an earlier onset of efficacy and lower rate of atypical sensations than the oral standard of care, which can be attributed to its fast absorption and low systemic exposure. AEs of abnormal taste are predominantly mild. These results confirm the initial design concept for AVP-825, which aligned pharmacokinetics, anatomy, and drug presentation in a novel device to achieve optimal outcomes for the acute treatment of migraine.