Miracle-dz/UniFAR-FTUs huggingface dataset:
Investigating the use of quick response codes in the gross anatomy laboratory

The use of quick response (QR) codes within undergraduate university courses is on the rise, yet literature concerning their use in medical education is scant. This study examined student perceptions on the usefulness of QR codes as learning aids in a medical gross anatomy course, statistically analyzed whether this learning aid impacted student performance, and evaluated whether performance could be explained by the frequency of QR code usage. Question prompts and QR codes tagged on cadaveric specimens and models were available for four weeks as learning aids to medical (n = 155) and doctor of physical therapy (n = 39) students. Each QR code provided answers to posed questions in the form of embedded text or hyperlinked web pages. Students' perceptions were gathered using a formative questionnaire and practical examination scores were used to assess potential gains in student achievement. Overall, students responded positively to the use of QR codes in the gross anatomy laboratory as 89% (57/64) agreed the codes augmented their learning of anatomy. The users' most noticeable objection to using QR codes was the reluctance to bring their smartphones into the gross anatomy laboratory. A comparison between the performance of QR code users and non‐users was found to be nonsignificant (P = 0.113), and no significant gains in performance (P = 0.302) were observed after the intervention. Learners welcomed the implementation of QR code technology in the gross anatomy laboratory, yet this intervention had no apparent effect on practical examination performance. Anat Sci Educ 8: 421–428. © 2014 American Association of Anatomists.
The Blooming Anatomy Tool (BAT): A discipline‐specific rubric for utilizing Bloom's taxonomy in the design and evaluation of assessments in the anatomical sciences

Bloom's taxonomy is a resource commonly used to assess the cognitive level associated with course assignments and examination questions. Although widely utilized in educational research, Bloom's taxonomy has received limited attention as an analytical tool in the anatomical sciences. Building on previous research, the Blooming Anatomy Tool (BAT) was developed. This rubric provides discipline‐specific guidelines to Blooming anatomy multiple‐choice questions (MCQs). To test the efficacy of the BAT, a group of volunteers were randomly split up and asked to Bloom a series of anatomy MCQs using either the BAT or a traditional Bloom's reference called Bloom's Learning Objectives (BLO). Both groups utilized each rubric for a different series of MCQs. Examination question categorizations made using each rubric were tested for accuracy and interrater reliability. In addition, previous experience in anatomy and Bloom's taxonomy were considered. Results demonstrated that volunteers using the BAT had consistently higher levels of interrater reliability, but accuracy varied and was similar between rubrics. Neither measure was substantially impacted by experience in Bloom's taxonomy or anatomy. A poststudy survey indicated that volunteers strongly preferred the BAT and felt it was more helpful in categorizing anatomy MCQs than the BLO. These results suggest that the BAT can be useful in educational research in the anatomical sciences to aid in aligning observer judgment on Bloom taxonomic levels and improve consistency, especially when used in conjunction with a norming session prior to data collection. Anat Sci Educ 8: 493–501. © 2014 American Association of Anatomists.
Simulating Personal Wealth in the Laboratory

ABSTRACT During laboratory gambling tasks participants are not typically allowed to wager their personal wealth. Instead, wealth is simulated by telling participants they have been endowed with game tokens that will be later exchanged for money. Past research indicates that participants undervalue game tokens following this procedure, which leads to elevated risk taking compared to procedures that add saliency or realism to the monetary payoff. A between-subjects experiment tested whether showing a picture of money during the endowment instructions and repeating token-money exchange information during the session influenced participants' preference for risky and riskless options. The results showed no effect of the money picture. However, repeated token-money exchange information significantly decreased risk taking. Together with past studies, this finding suggests that endowment procedures might establish greater value in game tokens, and therefore better simulate personal wealth, when the eventual exchange between game tokens and money is made more salient to participants.
False memories and the DRM paradigm: effects of imagery, list, and test type

ABSTRACT Several researchers have reported that instructing participants to imagine items using the Deese-Roediger-McDermott (DRM) paradigm lowers false memory rates (Foley, Wozniak, & Gillum, 2006). However, other researchers have found that imagery does not always lower false memory rates (Robin, 2010), and investigators have examined the effects of imagery manipulation on semantic but not phonological lists. In the present study, we presented 102 participants with semantic and phonological DRM lists, followed by a free recall test and final recognition test. Some participants received instructions to imagine list items during the study phase to facilitate memory, and others were simply told to remember list items. Imagery instructions enhanced correct memories and further suggested a trend for decreased false memories. A test type by list type interaction also emerged, with phonological lists eliciting higher false memories at recall, and semantic lists eliciting higher false memories at recognition. Directions for future research are discussed.
Influence of late irradiation on the in vitro RBC storage variables of leucoreduced RBCs in SAGM additive solution

Background There exists only few data on in vitro and in vivo effects of gamma irradiation of leucoreduced red blood cells (RBCs). Reported studies reflect the effects of early irradiation and subsequent storage. The effects of irradiation on RBCs shortly before the end of their shelf‐life have not been examined.
VARK learning preferences and mobile anatomy software application use in pre‐clinical chiropractic students

Ubiquitous smartphone ownership and reduced face‐to‐face teaching time may lead to students making greater use of mobile technologies in their learning. This is the first study to report on the prevalence of mobile gross anatomy software applications (apps) usage in pre‐clinical chiropractic students and to ascertain if a relationship exists between preferred learning styles as determined by the validated VARK© questionnaire and use of mobile anatomy apps. The majority of the students who completed the VARK questionnaire were multimodal learners with kinesthetic and visual preferences. Sixty‐seven percent (73/109) of students owned one or more mobile anatomy apps which were used by 57 students. Most of these students owned one to five apps and spent less than 30 minutes per week using them. Six of the top eight mobile anatomy apps owned and recommended by the students were developed by 3D4Medical. Visual learning preferences were not associated with time spent using mobile anatomy apps (OR = 0.40, 95% CI 0.12–1.40). Similarly, kinesthetic learning preferences (OR = 1.88, 95% CI 0.18–20.2), quadmodal preferences (OR = 0.71, 95% CI 0.06–9.25), or gender (OR = 1.51, 95% CI 0.48–4.81) did not affect the time students' spent using mobile anatomy apps. Learning preferences do not appear to influence students' time spent using mobile anatomy apps. Anat Sci Educ 9: 247–254. © 2015 American Association of Anatomists.
Identification of kallikrein and FXIa as impurities in therapeutic immunoglobulins: implications for the safety and control of intravenous blood products

Background and Objectives The occurrence of thromboembolic events (TEEs) with intravenous immunoglobulin lots (IVIGs) raised the question of the causative agent for these adverse events. We investigated the predominant plasma proteases in 19 IVIG lots from five manufacturers including three lots associated with adverse events.
Students’ Anticipated Situational Engagement: The Roles of Teacher Behavior, Personal Engagement, and Gender

ABSTRACT Among 9th-grade students (248 girls, 255 boys) from a large multiethnic school, the authors examined 2 aspects of anticipated situational engagement in relation to 3 types of hypothetical teacher behavior: authoritarian, authoritative, permissive. Furthermore, the authors investigated the moderating roles of students’ personal (trait-like) engagement and gender. Multilevel analyses showed differential effects of teacher behavior type. Anticipated situational engagement was generally highest with the authoritative teacher and lowest with the authoritarian teacher. However, students’ personal engagement and gender qualified these effects. The effects of the authoritative and authoritarian teachers versus the permissive teachers on anticipated situational engagement were more positive (or less negative) for students with high versus low personal engagement. Also, the positive effects of the authoritative and permissive teachers versus the authoritarian teacher were stronger for female students than for male students. Results show that anticipated situational engagement should be understood by examining the combined influences of contextual and individual characteristics.
New insights into pathogenesis of exercise-induced bronchoconstriction

Purpose of reviewExercise-induced bronchoconstriction (EIB) refers to acute airflow obstruction that is triggered by a period of physical exertion. Here we review recent findings about the epidemiology of EIB, immunopathology leading to EIB, and the latest understanding of the pathogenesis of EIB. Recent findingsLongitudinal studies demonstrated that airway hyper-responsiveness to exercise or cold air at an early age are among the strongest predictors of persistent asthma. Patients that are susceptible to EIB have epithelial disruption and increased levels of inflammatory eicosanoids such as cysteinyl leukotrienes (CysLT)s. The leukocytes implicated in production of eicosanoids in the airways include both a unique mast cell population as well as eosinophils. A secreted phospholipase A2 (sPLA2) enzyme that serves as a regulator of CysLT formation is present in increased quantities in asthma. Transglutaminase 2 (TGM2) is expressed at increased levels in asthma and serves as a regulator of secreted phospholipase A2 group X (sPLA2-X). Further, sPLA2-X acts on target cells such as eosinophils to initiate cellular eicosanoid synthesis. SummaryRecent studies have advanced our understanding of EIB as a syndrome that is caused by the increased production of inflammatory eicosanoids. The airway epithelium may be an important regulator of the production of inflammatory eicosanoids by leukocytes.
Promising pre-clinical validation of targeted radionuclide therapy using a [131I] labelled iodoquinoxaline derivative for an effective melanoma treatment

Targeted internal radionuclide therapy (TRT) would be an effective alternative to current therapies for disseminated melanoma treatment. At our institution, a class of iodobenzamides has been developed as potent melanomaseeking agents. This review described the preclinical validations of a quinoxaline derivative molecule (ICF01012) as tracer for TRT application. It was selected for its high, specific and long-lasting uptake in tumour with rapid clearance from non-target organs providing suitable dosimetry parameters for TRT. Extended in vivo study of metabolic profiles confirmed durable tumoural concentration of the unchanged molecule form. Moreover melanin specificity of ICF01012 was determined by binding assay with synthetic melanin and in vivo by SIMS imaging. Then, we showed in vivo that [131I] ICF01012 treatment drastically inhibited growth of B16F0, B16Bl6 and M4Beu tumours whereas [131I] NaI or unlabelled ICF01012 treatment was without significant effect. Histological analysis showed that residual tumour cells exhibit a significant loss of aggressiveness after treatment. This anti-tumoural effect was associated with a lengthening of the treated-mice survival time and an inhibition of lung dissemination for B16Bl6 model. Results presented here support the concept of TRT using a [131I] labelled iodoquinoxaline derivative for an effective melanoma treatment.
Medical students' attitudes toward the obese and the morbidly obese

One hundred third year medical students completed a questionnaire which elicited their reactions to obesity, including morbid obesity. The students' reactions toward the moderately obese were neutral or negative; while their reactions to the morbidly obese were almost uniformly negative. This is in contrast to their reactions to persons of average weight, which were neutral or positive. The negative prejudices expressed toward the morbidly obese extended beyond characteristics attributed to weight. Their negative feelings towards the obese did not change after direct contact with morbidly obese patients. Further research is needed to assess how prejudicial views toward obese people affect their medical care.
Progressive drawing: A novel “lid–opener” and “monotony–breaker”

An innovative strategy called “progressive drawing” was used at the beginning (lid‐opener) and later (monotony‐breaker) during gross anatomy lectures. Diagrams were drawn on the classroom blackboard with anatomic structures added one by one. Students identified and labeled the diagrams and predicted the next structures to be drawn. Students felt that the strategy helped to activate prior knowledge, created interest in the current lecture, and made lecture sessions more interactive. The strategy has appeal for visual, auditory, read/write, and kinesthetic learners. Anat Sci Educ, 2010. © 2010 American Association of Anatomists.
Self-Perceived Peer Acceptance in Preschoolers of Differing Economic and Cultural Backgrounds

ABSTRACT Self-evaluation begins in early childhood and becomes more nuanced as children get older. However, little is known about the specific factors that predict self-perception and in particular peer acceptance, early in life. This is especially true for low-income children and children of different ethnicities. This study examined 4-year-old children's feelings of social acceptance relative to teachers' perceptions. It also explored whether temperament, language skills, traditional parenting, and teachers' perceptions of peer acceptance were related to children's self-perceptions. Using 94 preschoolers from different cultural and economic backgrounds as participants, results of a mixed model analysis of variance indicated that the relation between children's self-perceptions and teachers' ratings were not uniform across economic and cultural groups. In addition, results of hierarchical multiple regression analyses demonstrated that traditional parenting was one of the strongest predictors of children's social self-perceptions. Beyond parenting, children with relatively good verbal skills, who were not temperamentally shy, tended to perceive themselves as socially competent.
Inborn errors of human IL-17 immunity underlie chronic mucocutaneous candidiasis

Purpose of reviewChronic mucocutaneous candidiasis (CMC) is characterized by recurrent or persistent symptomatic infection of the nails, skin and mucosae mostly by Candida albicans. CMC is common in patients with profound primary T-cell immunodeficiency, who often display multiple infectious and autoimmune diseases. Patients with syndromic CMC, including autosomal dominant hyper IgE syndrome (AD-HIES) and autosomal recessive autoimmune polyendocrinopathy syndrome type I (APS-I), display fewer other infections. Patients with isolated CMC (CMCD) rarely display any other severe disease. We review here recent progress in the genetic dissection of these three types of inherited CMC. Recent findingsLow IL-17 T-cell proportions were reported in patients with AD-HIES bearing heterozygous STAT3 mutations, prone to CMC and staphylococcal diseases, and in a kindred with autosomal recessive CARD9 deficiency, prone to CMC and other fungal infections. High levels of neutralizing autoantibodies against IL-17 cytokines were documented in patients with APS-I presenting with CMC as their only infectious disease. The first three genetic causes of CMCD were then reported: autosomal recessive IL-17RA and autosomal dominant IL-17F deficiencies and autosomal dominant STAT1 gain-of-function, impairing IL-17-producing T-cell development. SummaryInborn errors of human IL-17 immunity underlie CMC. Impaired IL-17 immunity may therefore account for CMC in other settings, including patients with acquired immunodeficiency.
Using embryology screencasts: A useful addition to the student learning experience?

Although podcasting has been a well used resource format in the last few years as a way of improving the student learning experience, the inclusion of enhanced audiovisual formats such as screencasts has been less used, despite the advantage that they work well for both visual and auditory learners. This study examines the use of and student reaction to a set of screencasts introduced to accompany embryology lectures within a second year module at Brighton and Sussex Medical School. Five mini‐lecture screencasts and one review quiz screencast were produced as digital recordings of computer screen output with audio narration and released to students via the managed learning environment (MLE). Analysis of server log information from the MLE showed that the screencasts were accessed by many of the students in the cohort, although the exact numbers were variable depending on the screencast. Students accessed screencasts at different times of the day and over the whole of the access period, although maximum downloads were predictably recorded leading up to the written examination. Quantitative and qualitative feedback demonstrated that most students viewed the screencasts favorably in terms of usefulness to their learning, and end‐of‐module written examination scores suggest that the screencasts may have had a positive effect on student outcome when compared with previous student attainment. Overall, the development of a series of embryology screencasts to accompany embryology lecture sessions appears to be a useful addition to learning for most students and not simply an innovation that checks the box of “technology engagement. ” Anat Sci Educ 4: 57–63, 2011. © 2011 American Association of Anatomists.
Frequency of CBFβ/MYH11 fusion transcripts in patients entered into the U.K. MRC AML trials

It has been established that cytogenetic findings at diagnosis of acute myeloid leukaemia (AML) are a powerful prognostic indicator. Patients who have the inv(16)(p13q22), closely associated with the FAB subtype M4Eo, are deemed to have good‐risk disease. This subtle translocation may be difficult to detect in poor‐quality metaphase preparations and if missed could lead to the incorrect assignment of risk group and influence further treatment strategies.
Prenatal environmental factors influencing IgE levels, atopy and early asthma

Purpose of reviewThere is increasing evidence that the prenatal window represents a critical period in which the developing immune system may be primed toward an allergic phenotype. Studies have investigated the role of a number of maternal environmental exposures on subsequent allergic disorders in the offspring. We summarize findings from recent studies on prenatal environmental factors influencing IgE levels, atopy, and early asthma. Recent findingsA building literature supports the influence of maternal exposure to environmental pollutants, such as allergens, traffic-related air pollution, tobacco smoke, and organochlorine compounds and social factors on allergic outcomes. More novel associations have been investigated, such as the effect of prenatal exposures to phthalates, bisphenol A, and magnetic fields. There is also rising interest in epigenetics as a pathway of action by which maternal exposure affect immune health. SummaryEmerging research highlights the challenges of investigating in-utero exposures and of relating exposures to such a heterogeneous and complex outcome as allergic disease. Further research is needed on the mechanisms by which prenatal exposure influences allergic response in childhood and how postnatal, familial and social factors, and sex can modify disease outcomes. Epigenetics is a promising new frontier, and likely one of several explanatory factors.
Are results of environmental exposure units transferable to real-life exposure?

Purpose of reviewTo reflect on and discuss the recent evidence of reliability of the challenge chamber results for real life, especially focusing on the validation of allergen concentrations being ‘physiologic’ and generating symptoms in the exposed volunteers comparable to the natural exposure during pollen season and to the home environment. Recent findingsPublications of the last 18 months covered by this review focus on the validation of allergen chamber systems, especially on the quantitative comparison of environmental allergen exposure with allergen challenge chamber (ACC) exposure. It highlights new evidence on the question of relevance of environmental and experimental priming effects and discusses the selection of relevant parameters for the quantification of treatment effects. SummaryBenchmarks for validating the ACC systems have been defined and are referred to in clinical ACC trials in increasing amount. So the level of evidence concerning the validity and reliability of allergen chamber systems is steadily growing, especially in allergen-specific models, priming effects and reproducibility of results in the same study population at different time points and with different challenge systems.
Evidence of preventive effect of probiotics and prebiotics for infantile eczema

Purpose of reviewInfantile eczema, and in particular atopic dermatitis are, in many children, the first manifestation of their predisposition to an atopic disease. Among existing prevention strategies, supplementation with probiotics and prebiotics belong to the most promising beneficial interventions. Highlighting the most recent literature, we review here the most recent studies on probiotics and prebiotics and hypothesize on the most efficient intervention strategies. Recent findingsVarious probiotics and prebiotics, either alone or in combinations, have been administered, in general, during the late phase of pregnancy and up to 6 months of age. In general, a combination of probiotics and prebiotics given from pregnancy until early infancy has a higher potential for protecting the infant from developing early manifestations of eczema than short administration of one specific microorganism. SummaryThe effect of probiotics and prebiotic supplementations on early manifestations of atopy such as infantile eczema are conflicting. Nevertheless, prevention strategies should aim for an enhanced efficacy by addressing not only interventions on the microbiota, but by combining them to other interventions, for example, to those aiming at actively inducing antigen-specific tolerance.