Miracle-dz/UniFAR-FTUs huggingface dataset:
Risk Assessment of Lead in Egyptian Vegetables and Fruits from Different Environments

Lead being a toxic heavy metal that mankind is exposed to the highest levels of this metal. There are different sources of environmental pollution with lead as lead alkyl additives in petrol and manufacturing processes. The contaminated atmosphere in urban and industrial areas by lead in Egypt may lead to the contamination of foods beside the other different sources. The present investigation studied the risk assessment of lead in some Egyptian edible vegetables and fruits collected from different environments in Greater Cairo Governorate, i.e. industrial, heavy traffic and rural areas. A total of 325 leafy and fruity vegetables and fruits samples belonging to 11, 6 and 4 different species, respectively were randomly collected from markets of the three main models. Data indicated the variation of lead levels in different three areas. The highest levels of lead were detected in the samples collected from industrial and traffic areas. However, the lowest levels were found in the rural areas. It could be concluded that determination of lead levels in foods from different localities and environments at regularly is very important. Keywords—Heavy metals, Lead, Vegetables, Fruits, Environments.
Insect-derived proline-rich antimicrobial peptides kill bacteria by inhibiting bacterial protein translation at the 70S ribosome.

Proline-rich antimicrobial peptides (PrAMPs) have been investigated and optimized by several research groups and companies as promising lead compounds to treat systemic infections caused by Gram-negative bacteria. PrAMPs, such as apidaecins and oncocins, enter the bacteria and kill them apparently through inhibition of specific targets without a lytic effect on the membranes. Both apidaecins and oncocins were shown to bind with nanomolar dissociation constants to the 70S ribosome. In apidaecins, at least the two C-terminal residues (Arg17 and Leu18) interact strongly with the 70S ribosome, whereas residues Lys3, Tyr6, Leu7, and Arg11 are the major interaction sites in oncocins. Oncocins inhibited protein biosynthesis very efficiently in vitro with half maximal inhibitory concentrations (IC50 values) of 150 to 240 nmol L(-1). The chaperone DnaK is most likely not the main target of PrAMPs but it binds them with lower affinity.
Modus Operandi of Female Serial Killers

The modus operandi of female serial killers was examined from a chronology of 58 cases in America and 47 cases in 17 other countries, compiled over 25-year intervals. Female serial killers in other countries accounted for a disproportionately greater number of victims, but those in America managed a longer killing career when associated with a low profile modus operandi.
Anterior Column Support in Surgery for High-Grade, Isthmic Spondylolisthesis

The literature is confusing as to the need for anterior column fusion in the surgical treatment of patients with high-grade dysplastic spondylolisthesis. The current authors present an analysis of consecutive pediatric patients treated surgically for high-grade spondylolisthesis with and without anterior column structural support with emphasis on fusion rates, segmental kyphosis correction, and functional outcomes. Thirty-seven surgical procedures were done in 31 patients for Meyerding Grade 3 or Grade 4 isthmic dysplastic spondylolisthesis. Patients were separated into two groups based on whether they had structural anterior column support (tricortical autogenous iliac crest) in addition to posterior fusion surgery. Group 1 consisted of 18 patients treated only with posterior surgery without anterior structural support (11 patients were treated with L4-sacrum posterior in situ fusion and seven patients were treated with posterior instrumented reduction with decompression and posterior fusion), and Group 2 consisted of 19 patients who had a reduction and circumferential fusion including anterior structural support. All patients had new radiographs taken at the time of followup (average, 3.1 years, range, 2 years–10 years 1 month) and completed a functional outcome questionnaire. The incidence of pseudarthrosis was 39% (seven of 18 patients) in Group 1 and 0% (0 of 19) in Group 2. All seven patients who had pseudarthrosis achieved solid fusion with a second procedure involving circumferential fusion with anterior column structural grafting. Outcomes regarding pain after treatment, function, and satisfaction were high in those patients who achieved solid fusion regardless of surgical procedure.
Nasal diseases and psychological distress

A high rate of ENT doctors were murdered by nasal disordered patients in China recently. It is obviously important and urgent to find out whether there is any potential relationship between nasal diseases (ND) and psychological distress that might contribute to violent behavior. For this purpose, we carried out this literature review. There is a complex relationship between ND and psychiatric distress, which is mainly considered as a bidirectional causal relationship with other controversy opinions. However, most of the previous studies were found to be focused on allergic rhinitis and chronic rhinosinusitis, while reports about other ND were rare. Further study is still needed to uncover the secret aspects in this field, and more attentions need to be paid to other ND.
NEUROMUSCULAR TRANSMISSION OF TROPHIC EFFECTS *

When skeletal muscle is deprived of its motor nerve supply, it gradually undergoes a series of changes which have been termed “atrophic. ” Although denervated muscle may remain viable for months, it eventually degenerates, and is finally replaced by connective tissue and fat. This vital dependence of skeletal muscle on its nerve supply led to the classical concept that the nerve normally provides some substance or effect necessary to the survival of the muscle, i.e., the “trophic influence. ” More recently, it has become clear that the nerves also regulate certain metabolic and physiological properties of muscles in a way that adapts them for their appropriate tasks. Both the nervous influences which contribute to survival of muscle and those which regulate its adaptation may be defined as trophic. In general, only long-term effects are included in this category. ’ Although long-term cannot be precisely defined, it is understood to exclude the immediate effects of acetylcholine ( ACh) transmission, in terms of membrane permeability, ion flux, and so on. However, the definition does not exclude the possibility that the cumulative effects of repeated ACh transmission may participate in conveying neurotrophic influences to muscle. Until recently, the trophic relationship between nerve and muscle was studied largely from the point of view of the muscle’s morphology, biochemistry and physiology. The changes occurring in muscle after denervation or other experimental procedures have been catalogued in detail elsewhere,24 and will be touched upon only as necessary here. The purpose of this presentation is rather to examine the current evidence concerning the mechanism (or mechanisms) by which neurotrophic influences are transmitted to muscle.
Reducing fabrication variability in analog IC technology by the statistical error propagation method using simple test structures

The statistical error propagation method is used to analyze the parametric variance of current gain and breakdown voltage in bipolar analog integrated circuits in terms of the relative variance of four process factors; emitter sheet resistance, based sheet resistance, buried layer sheet resistance, and epitaxial thickness. The dominant level of device parameter variance and the dominant process factors to which the device is sensitive are identified, using simple test structures, thereby facilitating the tightening of variability of the device parameter. This technique is useful for integrating the device data into the process control analysis and separating the effects of the critical process factors in a fabrication environment. How the process variance of analog integrated circuits is improved by this method is demonstrated. <<ETX>>
TDMAC: A timestamp defined message authentication code for secure data dissemination in VANET

Message authentication codes (MACs) are used to prevent the dissemination of unauthorized and corrupted message to avoid road accident in vehicular ad hoc network (VANET). VANET is a short-lived network due to high mobility of vehicles and hence can't afford any complex computation of existing MACs. A timestamp defined MAC (TDMAC) is proposed in the present work as a light weight security solution. Detailed security analysis shows that TDMAC also thwarts passive attack as well as active attack. Finally the comparative usability of the proposed algorithm in the said application domain is worked out and that shows the dominance of the scheme over the existing schemes.
Future Riverine Inorganic Nitrogen Load to the Baltic Sea From Sweden: An Ensemble Approach to Assessing Climate Change Effects

The dramatic increase of bioreactive nitrogen entering the Earth's ecosystems continues to attract growing attention. Increasingly large quantities of inorganic nitrogen are flushed from land to water, accelerating freshwater, and marine eutrophication. Multiple, interacting, and potentially countervailing drivers control the future hydrologic export of inorganic nitrogen. In this paper, we attempt to resolve these land‐water interactions across boreal/hemiboreal Sweden in the face of a changing climate with help of a versatile modeling framework to maximize the information value of existing measurement time series. We combined 6,962 spatially distributed water chemistry observations spread over 31 years with daily streamflow and air temperature records. An ensemble of climate model projections, hydrological simulations, and several parameter parsimonious regression models was employed to project future riverine inorganic nitrogen dynamics across Sweden. The median predicted increase in total inorganic nitrogen export from Sweden (2061–2090) due to climate change was 14% (interquartile range 0–29%), based on the ensemble of 7,500 different predictions for each study site. The overall export as well as the seasonal pattern of inorganic nitrogen loads in a future climate are mostly influenced by longer growing seasons and more winter flow, which offset the expected decline in spring flood. The predicted increase in inorganic nitrogen loading due to climate change means that the political efforts for reducing anthropogenic nitrogen inputs need to be increased if ambitions for reducing the eutrophication of the Baltic Sea are to be achieved.
Aquaporin 4‐Dependent expression of glial fibrillary acidic protein and tenascin‐C in activated astrocytes in stab wound mouse brain and in primary culture

We previously reported that aquaporin 4 (AQP4) has a neuroimmunological function via astrocytes and microglial cells involving osteopontin. AQP4 is a water channel localized in the endofoot of astrocytes in the brain, and its expression is upregulated after a stab wound to the mouse brain or the injection of methylmercury in common marmosets. In this study, the correlation between the expression of AQP4 and the expression of glial fibrillary acidic protein (GFAP) or tenascin‐C (TN‐C) in reactive astrocytes was examined in primary cultures and brain tissues of AQP4‐deficient mice (AQP4/KO). In the absence of a stab wound to the brain or of any stimulation of the cells, the expressions of both GFAP and TN‐C were lower in astrocytes from AQP4/KO mice than in those from wild‐type (WT) mice. High levels of GFAP and TN‐C expression were observed in activated astrocytes after a stab wound to the brain in WT mice; however, the expressions of GFAP and TN‐C were insignificant in AQP4/KO mice. Furthermore, lipopolysaccharide (LPS) stimulation activated primary culture of astrocytes and upregulated GFAP and TN‐C expression in cells from WT mice, whereas the expressions of GFAP and TN‐C were slightly upregulated in cells from AQP4/KO mice. Moreover, the stimulation of primary culture of astrocytes with LPS also upregulated inflammatory cytokines in cells from WT mice, whereas modest increases were observed in cells from AQP4/KO mice. These results suggest that AQP4 expression accelerates GFAP and TN‐C expression in activated astrocytes induced by a stab wound in the mouse brain and LPS‐stimulated primary culture of astrocytes. © 2014 Wiley Periodicals, Inc.
Oral and radiographic findings in patients undergoing continuous ambulatory peritoneal dialysis.

OBJECTIVE To compare the oral status, cortical and spongy bone density of the mandible, and dental pulp calcification between the patients undergoing continuous ambulatory peritoneal dialysis (CAPD) and age- and sex-matched healthy controls. MATERIAL AND METHOD Thirteen end stage renal disease patients undergoing CAPD and 17 age- and sex- matched healthy volunteers were enrolled. The questionnaires, oral radiography, and intraoral examination, including number of decayed teeth, filled teeth, missing teeth, plaque index, gingival index, calculus index, and oral hygiene index were performed in both groups. Two views of oral radiology, comprising panoramic and bite-wing radiographs, were taken to evaluate mandibular bone density and pulp calcification. The data were analyzed with t-test and Mann-Whitney U tests. RESULTS Both groups were similar in baseline demographics, including age, sex, and education. Plaque index, calculus index, and oral hygiene index of the CAPD patients were significantly worse than the controls' (p = 0.025, 0.015, and 0.014, respectively). Percentage of decayed teeth and missing teeth of the CAPD patients had a trend to be higher than control. The percentage of filled teeth, decayed missing filling tooth (DMFT) index, sum of percentage DMFT, gingival index, average of spongy and cortical bone densities, and the percentage of pulp calcification were comparable in both groups. CONCLUSION CAPD had poorer oral hygiene than the healthy; however; DMFT pulp calcification, and bone density were not differenct from the healthy. This urges the medical personnel to examine all CAPD patients in order to prevent hematogenous spreading of occult oral infection.
Rehabilitation therapy self-efficacy and functional recovery after hip fracture

Little is known about the role of psychological factors in the functional recovery process of hip fracture patients. This study employed a prospective cohort design to test the hypothesis that hospitalized hip fracture patients with greater reported self-efficacy for conducting rehabilitation therapy would have a greater likelihood of recovering to a pre-fracture level of locomotion function six months after the fracture. This hypothesis was tested controlling for pre-fracture level of function and depressive symptoms reported during hospitalization for surgical repair. An original measure of rehabilitation therapy self-efficacy was evaluated prior to hypothesis testing. Study patients were recruited from two hospitals, interviewed during hospitalization and followed up six months later. Patients included in hypothesis test analyses (n = 24) were mostly women (82%) with a mean age of 79 years. Results showed that patients with higher self-efficacy scores had a greater likelihood of locomotion recovery, controlling for pre-fracture locomotion function level (adjusted odds ratio (AOR) = 1.21; 95% confidence interval (CI) = 1.00–1.45;P = 0.05). This positive association between rehabilitation therapy self-efficacy and likelihood of locomotion recovery persisted after adding depressive symptoms (the Center for Epidemiological Studies-depression (CES-D) score) to this logistic regression model (AOR for self-efficacy = 1.18; 95% CI = 0.99–1.42;P = 0.07). It is concluded that rehabilitation therapy self-efficacy is a potentially important psychological factor in helping hip fracture patients recover locomotion functioning.
Variability of Alt a 1 expression by different strains of Alternaria alternata.

BACKGROUND While it is well known that there is significant intraspecific variation in the content an potency of Alternaria alternata allergens, little data has been published on intraspecific variability for individual allergens from moulds. OBJECTIVE To assess the variability of Alt a 1 expression in different strains of A alternata. METHODS Eleven strains of A alternata were cultured in a Czapek broth medium and culture filtrate extracts were obtained. A sensitive two-site enzyme-linked immunosorbent assay was used to measure Alt a 1 concentrations in medium following 3 weeks of culture and in culture filtrate extracts. RESULTS Expression of Alt a 1 was highly variable in different strains ofA alternata (coefficient of variation > 135%). A good correlation was found between Alt a 1 concentrations at the beginning of the process and measurements at the end of extract production (r=0.940). CONCLUSIONS The high variability of Alt a 1 expression in different A alternata strains makes it necessary to measure Alt a 1 concentrations during the first stage of allergenic extract production in order to be able to choose a suitable strain for producing extracts or purifying Alt a 1.
Outlier Detection for Text Data

The problem of outlier detection is extremely challenging in many domains such as text, in which the attribute values are typically non-negative, and most values are zero. In such cases, it often becomes difficult to separate the outliers from the natural variations in the patterns in the underlying data. In this paper, we present a matrix factorization method, which is naturally able to distinguish the anomalies with the use of low rank approximations of the underlying data. Our iterative algorithm TONMF is based on block coordinate descent (BCD) framework. We define blocks over the term-document matrix such that the function becomes solvable. Given most recently updated values of other matrix blocks, we always update one block at a time to its optimal. Our approach has significant advantages over traditional methods for text outlier detection. Finally, we present experimental results illustrating the effectiveness of our method over competing methods.
Loss of integrin linked kinase from mouse hepatocytes in vitro and in vivo results in apoptosis and hepatitis

Extracellular matrix (ECM) is fundamental for the survival of cells within a tissue. Loss of contact with the surrounding ECM often causes altered cell differentiation or cell death. Hepatocytes cultured without matrix lose patterns of hepatocyte‐specific gene expression and characteristic cellular micro‐architecture. However, differentiation is restored after the addition of hydrated matrix preparations to dedifferentiated hepatocytes. Integrin‐linked kinase (ILK) is an important component of cell–ECM adhesions transmitting integrin signaling to the interior of the cell. ILK has been implicated in many fundamental cellular processes such as differentiation, proliferation, and survival. In this study, we investigated the role of ILK in mouse hepatocytes in vitro as well as in vivo. Depletion of ILK from primary mouse hepatocytes resulted in enhanced apoptosis. This was accompanied by increased caspase 3 activity and a significant decrease in expression of PINCH and α‐parvin, which, along with ILK, form a stable well‐characterized ternary complex at cell–ECM adhesions. The induction of apoptosis caused by ILK depletion could be substantially reversed by simultaneous overexpression of ILK, indicating that apoptosis is indeed a consequence of ILK removal. These results were further corroborated via in vivo data showing that adenoviral delivery of Cre‐recombinase in ILK‐floxed animals by tail vein injection resulted in acute hepatitis, with a variety of pathological findings including inflammation, fatty change, and apoptosis, abnormal mitoses, hydropic degeneration, and necrosis. Conclusion: Our results demonstrate the importance of ILK and integrin signaling for the survival of hepatocytes and the maintenance of normal liver function. (HEPATOLOGY 2007.)
Motor Learning in Individuals With Autism Spectrum Disorder: Activation in Superior Parietal Lobule Related to Learning and Repetitive Behaviors

Motor‐linked implicit learning is the learning of a sequence of movements without conscious awareness. Although motor symptoms are frequently reported in individuals with autism spectrum disorder (ASD), recent behavioral studies have suggested that motor‐linked implicit learning may be intact in ASD. The serial reaction time (SRT) task is one of the most common measures of motor‐linked implicit learning. The present study used a 3T functional magnetic resonance imaging scanner to examine the behavioral and neural correlates of real‐time motor sequence learning in adolescents and adults with ASD (n = 15) compared with age‐ and intelligence quotient‐matched individuals with typical development (n = 15) during an SRT task. Behavioral results suggested less robust motor sequence learning in individuals with ASD. Group differences in brain activation suggested that individuals with ASD, relative to individuals with typical development, showed decreased activation in the right superior parietal lobule (SPL) and right precuneus (Brodmann areas 5 and 7, and extending into the intraparietal sulcus) during learning. Activation in these areas (and in areas such as the right putamen and right supramarginal gyrus) was found to be significantly related to behavioral learning in this task. Additionally, individuals with ASD who had more severe repetitive behavior/restricted interest symptoms demonstrated greater decreased activation in these regions during motor learning. In conjunction, these results suggest that the SPL may play an important role in motor learning and repetitive behavior in individuals with ASD. Autism Res 2015, 8: 38–51. © 2014 International Society for Autism Research, Wiley Periodicals, Inc.
Medical treatment of male infertility

Although male factors contribute to approximately half of all cases of infertility, no specific cause can be found to explain the majority of abnormalities found in semen parameters. Specific and effective medical treatment is restricted to rare endocrine disorders. As a consequence, various empirical medical treatments are often used to treat idiopathic male infertility, with limited success. This review focuses on the rationale and current evidence on the efficacy of medical treatment of male infertility. Unless new studies provide high quality evidence in favour of medical treatment, assisted reproductive technologies will remain the mainstay of treatment of male infertility.