Miracle-dz/UniFAR-FTUs huggingface dataset:
Factors affecting acceptance of mobile content services among mature consumers

Niemela-Nyrhinen, Jenni Factors Affecting Acceptance of Mobile Content Services among Mature Consumers Jyvaskyla: University of Jyvaskyla, 2009, 148 p. (Jyvaskyla Studies in Business and Economics ISSN 1457-1986; 72) ISBN 978-951-39-3485-9 (PDF), 978-951-39-3466-8 (nid.) Mobiilien sisaltopalveluiden omaksumiseen vaikuttavat tekijat ikaantyvien kuluttajien keskuudessa Diss. The aim of this study is to increase our understanding of mature consumers as users of technological services. More specifically, the objective is to find out which factors have an effect on the acceptance of mobile content services in the target group. The services studied are mobile services, including content that is provided by a service provider. Examples of mobile content services are mobile news, mobile banking and downloading ringing tones. In order to arrive at a theoretical model, the previous literature on technology acceptance is explored from a general and a more age group-specific perspective. The literature review is multidisciplinary, concentrating on knowledge generated in marketing and information systems science. The model that is tested in the empirical part is synthesised from the Technology Acceptance Model, TAM (including perceived usefulness, perceived enjoyment, perceived ease of use and behavioural intention) and four individual difference variables (cognitive age, technology anxiety, prior similar experience and subjective norm). In this study mature consumers are represented by Finnish baby boomers (born between 1945 and 1955). The data (620 usable responses) were gathered through a structured postal questionnaire. The main analytical method used is structural equation modelling (SEM). TAM proved to explain mobile content services acceptance among Finnish baby boomers extremely well. In addition, the four individual difference variables were shown to have an effect on one or more of the variables of TAM. On the basis of the results consideration is given to the theoretical contributions, practical implications and limitations of the study, and suggestions for future research are made.
A method for the selection of appropriate business-to-business integrated marketing communications mixes

Integrated marketing communications (IMC) are expressly conceived for appropriate communications strategy planning in the increasingly interactive,fragmented,cluttered and global communications environment that is today's market-place. To be effective, the aspect of the IMC model that is concerned with communication from the manufacturer or distributor to the consumer proposes that marketers must now more than ever ensure that the sum total of their marketing communications in all its forms be carefully coordinated so that they all speak collectively with one voice, thereby amplifying and reinforcing the core organizational or brand message. To date, however, most of the research emphasis on IMC has been devoted to consumer marketing. The purpose of this paper is to examine marketing managers' perceptions in the US trucking industry. Correspondence analysis was used for revealing associations between the promotional tools currently used in the US trucking industry and their specific communications function. The results suggest that US trucking managers link their deployment of respective promotional tools to the separate stages of the consumer choice process, as exemplified by the new product adoption model. The fact that the managers in this recently deregulated industry have come to deploy their promotional tools in such a manner implies that the new product adoption model may serve as a template for marketers looking for a guide for effectively selecting a complementary array of marketing communications tools.
Canonical Wnt/β‐catenin signaling is required for maintenance but not activation of Pitx2 expression in neural crest during eye development

Pitx2 is a paired‐like homeodomain gene that acts as a key regulator of eye development. Despite its significance, upstream regulation of Pitx2 expression during eye development remains incompletely understood. We use neural crest‐specific ablation of Ctnnb1 to demonstrate that canonical Wnt signaling is not required for initial activation of Pitx2 in neural crest. However, canonical Wnt signaling is subsequently required to maintain Pitx2 expression in the neural crest. Eye development in Ctnnb1‐null mice appears grossly normal early but significant phenotypes emerge following loss of Pitx2 expression. LEF‐1 and β‐catenin bind Pitx2 promoter sequences in ocular neural crest, indicating a likely direct effect of canonical Wnt signaling on Pitx2 expression. Combining our data with previous reports, we propose a model wherein a sequential code of retinoic acid followed by canonical Wnt signaling are required for activation and maintenance of Pitx2 expression, respectively. Other key transcription factors in the neural crest, including Foxc1, do not require intact canonical Wnt signaling. Developmental Dynamics 239:3215–3225, 2010. © 2010 Wiley‐Liss, Inc.
Doppler Ultrasound Signal in Achilles Tendinopathy Reduces Immediately After Activity

Abstract Background: A relationship has been identified between vascularization on Doppler ultrasound (Doppler signal) and Achilles tendon pain. Doppler signal may increase minutes after prolonged activity, but the immediate effect is unknown. The aim of the study was to investigate the immediate effect of short term activity on Achilles tendon Doppler signal. Achilles tendinopathy patients (7 patients, 10 tendons) and asymptomatic controls (6 controls, 12 tendons) performed 2 activity tasks; a 2 minute continuous step task and one minute continuous calf raise task. Doppler signal was measured at rest and within a minute after each activity. The presence of Doppler signal was quantified using both semi quantitative (modified Ohberg scale; 0=no signal, 5=>90% of pathological area contains Doppler signal) and quantitative methods (pixel number). Doppler signal was present in 90% of symptomatic individuals and in none of the asymptomatic controls. The modified Ohberg scale and pixel number reduced significantly after both activity tasks and heart rate increased significantly (p<0.05). Doppler signal in Achilles tendinopathy may decrease immediately after activities that load the calf muscle and increase heart rate, suggesting that this activity should be avoided prior to imaging to avoid false negative results.
Peripheral Arterial Disease and Cognitive Function

Objective Peripheral arterial disease (PAD) is associated with comorbid atherosclerosis of the coronary and carotid arteries and is a significant risk factor for stroke. However, cognitive function in PAD patients before clinically evident stroke remains poorly characterized. Here we hypothesized that, on neuropsychological testing, PAD patients would perform more poorly than healthy control subjects, and persons with mild cardiovascular disease (essential hypertension), but better than stroke patients, thus reflecting a continuum of cognitive impairment associated with increased severity of vascular disease. Method The cognitive performance of 38 PAD patients (mean ankle-brachial index=0.67, Fontaine Class II) was contrasted with that of 23 healthy normotensive controls, 20 essential hypertensives, and 26 anterior ischemic stroke patients on twelve neuropsychological tests. Results PAD patients performed significantly more poorly than hypertensives and normotensives, but better than stroke patients, on seven tests of nonverbal memory, concentration, executive function, perceptuo-motor speed, and manual dexterity. Hypertensives displayed poorer performance than normotensives on tests of nonverbal memory and manual dexterity. These findings were independent of age, education, and depression scores. Higher diastolic blood pressure and plasma glucose levels predicted poorer performance of select cognitive tests by PAD patients. Eight to 67% of PAD patients displayed impaired performance (< 5th percentile of normotensive controls) on the seven aforementioned cognitive tests. Conclusions PAD patients exhibit diminished performance across a variety of domains of cognitive function. Findings also suggest a continuum of cognitive impairment associated with increasingly severe manifestations of cardiovascular disease, thus emphasizing the need for enhanced preventative measures to avert functional declines.
Pharmacokinetics and Bioavailability of Mycophenolate Mofetil in Healthy Subjects after Single‐Dose Oral and Intravenous Administration

A randomized, crossover study of 12 healthy volunteers was conducted with single, 1.5‐g doses of mycophenolate mofetil (MMF), a prodrug of mycophenolic acid (MPA), after oral and intravenous administration. During the intravenous infusion, phase systemic plasma clearance of MMF was ∼10 L/min and the half‐life (t1/2) was a few minutes. After oral administration, however, plasma MMF was below quantitation limits at all times. The plasma MPA profile of oral MMF showed a sharp peak at ∼1 hour and a secondary peak at 8 to 12 hours. Mean apparent plasma t1/2 of MPA was similar for both routes (∼17 hours). The area under the concentration‐time curve (AUC) from time 0 to 24 hours was statistically higher for intravenous than for oral administration, but total AUC showed statistical equivalence (80–120 rule), with mean bioavailability of MPA from oral administration of MMF estimated as 94.1% relative to the intravenous route. Total plasma AUC of mycophenolic acid glucuronide (MPAG), the sole metabolite of MPA, was four‐ to five‐fold higher than MPA. Total 48‐hour MPAG recovery in urine was statistically equivalent for the two routes and represented a mean of 70% of administered drug; corresponding MPA recovery was less than 1%. Renal clearance (CIr) values required transport mechanisms for MPAG, but not for MPA. The CIR of MPAG was statistically higher after intravenous administration than oral administration. MMF administered orally undergoes rapid, complete absorption and essentially complete presystemic deesterification. There was presystemic removal of MPA, but enterohepatic circulation compensated for the first pass loss. Renal metabolism of MPA also may have occurred.
The Swiss Household Panel Study : Observing social change since 1999

Collecting data on households and individuals since 1999, the Swiss Household Panel (SHP) is an ongoing, unique, large-scale, nationally representative, longitudinal study in Switzerland (N=7,383 households and N=12,119 persons interviewed in 2014). The data of the SHP provide a rich source of information to study social change in Switzerland over a significant period on a wide variety of topics. The SHP aims to provide both continuity and innovation in measurement and data collection, with the combination of retrospective and prospective longitudinal data in the most recent refreshment sample as one notable example of such an innovation. This paper provides an overview of the SHP – focusing on its origin, aims, design, content, data collection and adjustments, possibilities for cross-national comparisons, data use and accomplishments.
Development of tolerance to anticonvulsant effect of clobazam.

had regained consciousness. This tracing was normal and the background activity consisted of occipital dominant alpha rhythm. The blood glutethimide level had dropped to 0*38 mg/dl by this time. A third EEG tracing obtained 12 days later was again normal. BAERs were obtained a day after admission and were normal. Her hospital course was complicated by transient aspiration pneumonia. After recovery, she was transferred to a psychiatric hospital without any neurological deficit. Although previously commented on by a few authors,79' alpha coma has not been widely recognised in drug intoxication uncomplicated by cerebral anoxia. One needs to keep in mind that drug-induced alpha coma has a distinctly different prognosis from that in patients with hypoxic encephalopathy of primary brainstem lesions; the patients with drug-induced alpha coma have an excellent prognosis. All nine cases of alpha coma caused by drugs, including the patient in this report, recovered without any neurological sequelae. Drug-induced alpha coma has resulted from an overdose of sedative drugs such as amytriptyline, barbiturates, glutethimide, nitrazepam, and chlormethiazole. Two patients7 had the further complication of respiratory depression and hypoxia of variable duration; even these made a full recovery. The EEG findings of drug-induced alpha coma are different from those observed in patients with hypoxic encephalopathy of brainstem lesions. The alpha activity is widespread and is usually predominant over the anterior regions. Unlike the patients *with hypoxic encephalopathy, patients with drug-induced alpha coma may show some reactivity of their EEG to intense painful stimulation; slower activity (usually low amplitude theta-delta) may be induced for a short period during and after stimulation. The presence of reactivity does not, however, distinguish alpha coma due to drug intoxication from that due to brainstem lesions because the latter may also be associated with some EEG reactivity.8 Multimodality evoked responses in coma have proved helpful in determining the level of the damage to the brainstem. '3'4 BAERs, in particular, are helpful in the assessment of a patient with alpha coma where the cause of coma remains undetermined and are grossly abnormal in alpha coma secondary to intrinsic brainstem lesion. '3 Normal BAERs on the other hand, suggest integrity of the brainstem structures and favour either drug intoxication or hypoxic encephalopathy responsible for the comatose state. The mechanism of normal BAERs, despite the absence of brainstem reflexes in sedative drug intoxication is unclear, but one may postulate that the generator site of the responses is suppressed,'0 but anatomically is intact and reactive to auditory stimulus. The recognition of sedative drug intoxication as an important cause of alphapattern coma is crucial because the prognosis in such patients with intensive supportive therapy is excellent.
Customer Experience and Its Relative Influence on Satisfaction and Behavioural Intention in Hospitality and Tourism Industry

The present study aims to determine the relative influence on satisfaction and behavioural intention in hospitality and tourism industry especially in different chain of hotel brands in north India and determining how customer experience are varied at different chain of hotels? The research instrument was used as self administered questionnaire consisted of several rating scales to capture the study’s main variables namely: customer experience, satisfaction and behavioural intention. 600 useable responses were received from the respondents. The four dimensions of customer experience i.e. education, entertainment, escapism and aesthetic was identified. It was found that there is positive relationship between customer experience satisfaction and behavioural intention. The finding of the study leaves the implications for the hospitality marketers on the “entertainment” and “aesthetic aspect” as important dimensions of customer experience, and special assistance needed on the dimensions of landscape, marketing and advertising campaigns, overall experience, meals and food offerings, interior design and architecture.
Improving Prelaunch Diffusion Forecasts: Using Synthetic Networks as Simulated Priors

Although the role of social networks and consumer interactions in new product diffusion is widely acknowledged, such networks and interactions are often unobservable to researchers. What may be observable, instead, are aggregate diffusion patterns for past products adopted within a particular social network. The authors propose an approach for identifying systematic conditions that are stable across diffusions and thus are “transferrable” to new product introductions within a given network. Using Facebook applications data, the authors show that incorporation of such systematic conditions improves prelaunch forecasts. This research bridges the gap between the disciplines of Bayesian statistics and agent-based modeling by demonstrating how researchers can use stochastic relationships simulated within complex systems as meaningful inputs for Bayesian inference models.
Adoptive chemoimmunotherapy using Ex vivo activated memory T‐cells and cyclophosphamide: Tumor lysis syndrome of a metastatic soft tissue sarcoma

Adoptively transferred immune cells in combination with chemotherapeutic agents form the basis for adoptive chemoimmunotherapy (ACIT) of neoplastic disease. Autolympho‐cytes (ALT‐cells) are ex vivo activated peripheral blood lymphocytes (PBL) from tumor‐bearing hosts (TBH) that consist primarily of tumor‐specific CD45RO+ (memory) T‐cells. These ALT‐cells combined with cimetidine (CIM) as autolymphocyte therapy (ALT), have previously been demonstrated to be a safe and active form of outpatient adoptive immunotherapy (AIT) in human TBH with metastatic renal cell cancer (RCC). We have previously described an effective ACIT protocol using ALT and cyclophosphamide (CY) for patients with relapsed and refractory non‐RCC solid tumors. We now report a case of a patient with a metastatic gastric leiomyosarcoma to the liver, who developed a clinical picture consistent with a tumor‐lysis syndrome (TLS), following salvage therapy for his tumor with ACIT using ALT and CY. TLS is a well‐known complication resulting from the treatment of rapidly proliferating hematopoietic tumors such as Burkitt's lymphoma and acute lymphocytic leukemia. TLS has also been rarely described in chronic lymphocytic leukemia, as well as certain solid tumors such as breast cancer, small cell lung cancer, and medulloblastoma. However, there have been no previous reports of TLS occurring either secondary to immunotherapy or in sarcomas. The nature of these unusual findings is discussed. © 1993 Wiley‐Liss, Inc.
TEVAR for Ruptured type B Aortic Dissection in a Patient with Turner Syndrome

Abstract TEVAR has replaced open surgical repair as preferred treatment for complicated acute type B aortic dissection. But the literature on thoracic endovascular aortic repair (TEVAR) for ruptured type B dissection is scarce. Patients with Turner syndrome are at risk for aortic dissection and rupture at a young age with an immediate mortality rate of 63%. Only a few cases have been described and the best treatment is not yet established. We present a case of a 49 year-old woman with Turner syndrome who suffered from a ruptured aortic dissection Stanford type B. A TEVAR procedure was performed, but the life of the patient could not be saved. In this case report we discuss the lessons we learned as well as some unsolved questions about TEVAR for ruptured type B aortic dissection.
Consumer Persuasion: Indirect Change and Implicit Balance

The present research examines two main issues relevant to consumer persuasion: (1) whether automatic evaluations can change (both directly and indirectly) in response to verbal ads that engage deliberative information processing activity, and (2) whether such messages can result in spreading activation of implicit change that is consistent with balance principles. The first study showed that automatic evaluations of vegetables were more favorable after people read a health ad than a control message. The results of Study 2 showed that automatic associations toward Heineken (a brand associated with the color green) were also more favorable as a result of processing a message advocating the color green than a neutral control message. Consistent with the idea that automatic changes can be consequential not only for brands but also for consumer identity, participants of Study 3 showed more automatic self–vegetable associations after thinking about the benefits (rather than the negative consequences) of consuming vegetables. A final study revealed that false feedback increasing (vs. decreasing) self–product identity led to more favorable automatic attitudes toward the product, but only for those with relatively high scores on the implicit measure of selfesteem. Taken together, this series of studies suggests that automatic changes that result from consumer persuasion are consequential in terms of spreading activation and that they seem to respond to balance principles. © 2010 Wiley Periodicals, Inc.
Development of New Digester Technologies for Improved Adoption and Cost Reduction

Previous chapters within the Climate Friendly Farming (CFF) anaerobic digestion (AD) section have focused on the development of new auxiliary technologies that work in conjunction with the core digester. These technologies allow for the production of numerous co-products that enhance project economics and improve sustainability. In addition to these important technology developments, there is an equally strong need for improving digester design to reduce project capital costs and to allow for application of the core technology to waste materials other than scrape manure. Improved digester designs could accelerate the adoption of AD technology generating benefits for air and water quality and the climate.
Nuclear India - to be or not to be?

Nuclear India was conceived before independent India, and has undergone similar ups and downs in its development. Multiple conflicting opinions, controversies and secrecy have been its constant companions. The end result is that the common citizens of the country are not sure if nuclear power is good or bad for them. This article is an effort to collate different opinions and facts on the nuclear issue from the point of view of electrical energy production.
Assessment of plasma N-acetyl aspartic acid by Liquid chromatography-mass spectrometry in patients with Alzheimer ’ s disease

Objective: Alzheimer’s disease (AD) is a neural degenerative disease with progressive cognitive impairment. N-acetyl aspartic acid (NAA) is an important biomarker for assessing neuronal activity and brain cells metabolic abnormalities. This investigation is aimed to establish a liquid chromatography-mass spectrometry (LC-MS) method for measuring plasma NAA level, in order to make clear whether plasma NAA level can be used as a plasma biomarker in AD. Methods: A LC-MS method was established and validated for quantitative analysis of plasma NAA, and the plasma NAA concentrations of 23 AD patients and 36 healthy controls were analyzed and compared. In addition, the bilateral hippocampus NAA levels in 7 AD patients and 7 age-matched healthy controls were comparative analyzed by 1H-MRS method, and corresponding correlation analyses were also performed. Results: An optimized LC-MS method was applied for measuring plasma NAA levels. Plasma NAA levels were significantly higher in AD patients (14.02±2.324 μM) than controls (11.12±2.67 μM) (P<0.01), and statistically different between different age group in both AD patients and healthy controls (P<0.05), with a significantly negative correlation with age in healthy controls (r = -0.462, P = 0.008). The ratios of NAA/Ch, NAA/Cr in both hippocampus measured by 1H-MRS were significantly decreased in AD patients than in controls (P<0.05), and there were no statistical correlations between plasma NAA concentrations and NAA/Ch, NAA/Cr and Ch/Cr ratios in the selected 7 AD patients. Conclusions: LCMS method can be used as a simple, rapid and accurate quantitative analysis method for plasma NAA measurement. As NAA level increased in plasma and decreased in the brain, the plasma NAA level could be used as an index for early clinical AD screening.