Miracle-dz/UniFAR-FTUs huggingface dataset:
Implication of transfected cell lines for the detection of alloantibodies against human neutrophil antigen‐3

BACKGROUND: Alloantibodies against human neutrophil antigen‐3 (HNA‐3) are responsible for the fatalities reported in transfusion‐related acute lung injury. Consequently, reliable detection of these alloantibodies is mandatory to improve blood transfusion safety. In this study, we developed stable cell lines for the detection of HNA‐3 antibodies.
Misconceptions and Malpractices Toward Antibiotic Use in Childhood Upper Respiratory Tract Infections Among a Cohort of Lebanese Parents

Antimicrobial resistance is an emerging global health threat. Misuse and abuse of antibiotics are of particular concern in the pediatric population. Since management of childhood illnesses depends considerably on parents’ perceptions, the objectives of this study were to report parents’ perspectives and assess their practices toward antibiotics used for upper respiratory tract infections (URTIs) in children. Using a cross-sectional design, anonymous structured questionnaires were completed by 1,037 parents in public and private schools across Lebanon’s largest governorate. Descriptive statistics were used to report participants’ responses. A multivariate analysis was performed to identify factors affecting knowledge and malpractice related to antibiotic use. Significant misconceptions and malpractices were identified among parents. For instance, 33.9% of parents considered that antibiotics are helpful in treating common cold among children and 36.2% believed antibiotics expedite the recovery of their child with common cold infection. Moreover, there was a lack of knowledge concerning antibiotic coverage, since 37.9% of the respondents believed that antibiotics treat viral infections and 21.5% were neutral toward this question. Around 20% of the participants believed they can reduce the dose of antibiotics if the child gets better. Significant factors associated with poor knowledge and misuses were parents’ lower educational and socioeconomic levels. Despite extensive evidence on the limited role of antibiotics in URTIs, parents in Lebanon continue to misuse them. More concerted efforts are needed to improve parents’ knowledge and practices with regard to the rational use of antibiotics.
Wideband Shorted Patch Antenna Under Radiation of Dual-Resonant Modes

A novel design concept of enhancing the impedance bandwidth of a single-layer shorted microstrip patch antenna (MPA) is proposed under simultaneous radiation of the one- and three-quarter wavelength resonant modes (TM0,1/2 and TM0,3/2 modes). Initially, a conventional MPA with the shorting wall is studied to demonstrate that none of the redundant modes can be excited between the dual-resonant modes. Then, a pair of shorting pins are appropriately installed underneath the patch to progressively turn up the resonant frequency of TM0,1/2 mode without significant influence on that of TM0,3/2 mode. After that, a V-shaped slot is etched out on the patch to dramatically reduce the resonant frequency of TM0,3/2 mode with little effect on that of TM0,1/2 mode. With the use of these arrangements, the dual-desired radiative resonant modes are gradually moved in proximity to each other, thus widening the impedance bandwidth under emergence of dual resonant poles. In order to validate the principle and design method, the proposed antenna is designed, fabricated, and measured. The measured results demonstrate that the impedance bandwidth of the proposed shorted patch antenna has been extended to about 11.8%, and it is about 1.82 times of 6.5% of the traditional shorted MPA. Meanwhile, the fabricated antenna exhibits other attractive performances including stable radiation pattern, same polarization, and a low-profile property with the height of 0.042 free-space wavelength.
Cardiovascular Effects of Isoflurane‐Induced Hypotension for Cerebral Aneurysm Surgery

Deliberate hypotension was induced with isoflurane in 13 patients undergoing craniotomy for clipping of aneurysms. Cardiovascular function and gas exchange were monitored before, during, and after hypotension. In all cases, the desired level of hypotension [40 ± 1 (SEM) mm Hg] was achieved readily with prompt onset (5,7 ± 1.0 min) and recovery (6.3 ± 0.7 min). Cardiac output during hypotension (4.6 ± 0.3 L/min) was not significantly different from the control normotensive value (4.80 ± 0.3 L/min). Gas tensions during hypotension and during normotension were; Pao2 116 ± 6 and 111 ± 8 mm Hg; Paco2 33 ± 1 and 34 ± 1 mm Hg; respectively. No complication could be attributed to the use of isoflurane. We conclude that isoflurane can be employed safely and effectively as a hypotensive agent in neurosurgery.
General aspects and pitfalls in liver transplant pathology

Abstract: Pathology in a liver transplant setting addresses four different topics: establishment of a definite diagnosis of the liver disease before listing for transplantation, evaluation of the donor liver with regard to pre‐existing diseases, in particular macrovesicular steatosis and fibrosis, assessment of the hepatectomy specimen, and post‐transplant biopsy evaluation. Of these, post‐transplant biopsy evaluation is the most challenging and clinically the most relevant issue. It requires fast diagnoses to facilitate specific treatment and it has to incorporate a broad spectrum of differential diagnoses. Precise knowledge about rejection, post‐transplant therapy, pathology of immunosuppression, and recurrence of the initially underlying liver disease including the characteristic time peaks and atypical histological presentations (e.g., fibrosing cholestatic hepatitis) is needed to evaluate specific and combined histological pictures of liver damage. For adequate interpretation of post‐transplant biopsies the hepatopathologist has to be informed about the essential clinico‐anamnestic aspects such as time course, medication, imaging results, and serology.
The disappearance of 7-H-3-d-aldosterone in the plasma of normal subjects.

The study of the disappearance of the radioactivity in plasma after the injection of labeled aldosterone should elucidate the transport and metabolism of this steroid in man. In particular this would allow the calculation of the turnover rate in various clinical conditions. This value, together with a concomitant determination of the secretion rate estimated from the specific activity of a urinary metabolite, would enable the mean blood concentration of aldosterone to be calculated. This is particularly important at the present time, as no practical direct method has yet been reported for the analysis of aldosterone in peripheral blood. After the administration of 16-H13-aldosterone to one normal subject, the labeled hormone had a half-life in plasma of 20 minutes, as calculated from the change in concentration of radioactivity measured specifically as aldosterone between 2 and 3 hours after the injection (1). This indicated that the rate of metabolism of aldosterone was greater than that of cortisol and corticosterone. The data obtained were not sufficient to give a relialle estimate of volumes of distribution. Also, the low specific activity of aldosterone then available made it necessary to administer 2 jug of hormone. This amount represents about 25 per cent of total body pool of hormone. Peterson reported a corresponding half-life of 0.5 to 0.8 hour in normal subjects after injection of tritiated d,l-aldosterone (2). Again in this study large quantities of the hormone were injected. Also it is not known whether the optical isomers of aldosterone are metabolized in an identical manner. The natural hormone is in the d form exclusively.
Intimate Partner Violence Narrative Possibilities : Poor Women of Color and the Complexities of

This article shows how a narrative methodological approach is particularly suited to examining the dynamics of intimate partner violence, especially among poor women of color in South Africa. We show how a narrative approach allowed women to represent their experiences of violence according to their own frames of meaning, examining the complexities of abuse as it is informed by sociocultural factors of gender, poverty, and deprivation. In particular, we show how a narrative approach departs from other qualitative work by enabling women to construct particular forms of identity, thereby giving them agency in authoring their own stories of violence.
Co‐expression of B7‐1 and ICAM‐1 on tumors is required for rejection and the establishment of a memory response

Although the transfection of B7‐1 cDNA into a few mouse tumor cell lines can induce anti‐tumor T cell immunity, its expression alone is ineffective in many other tumor cell lines tested. We were interested to study what factors limit B7‐1 co‐stimulatory activity, and decided to investigate whether B7‐1 requires the cooperation of ICAM‐1 to provide the minimal co‐stimulatory signal for establishing an efficient anti‐tumor immunity. We show that the transfection of B7‐1 cDNA into three ICAM‐1+ (plasmocytoma J558L, T lymphomas EL‐4 and RMA), but not into two ICAM‐1− tumor cell lines (adenocarcinoma TS/A and melanoma B16.F1), is sufficient to induce their complete rejection in syngeneic mice. The expression of ICAM‐1 is necessary for the rejection of the B7 expressing tumors, since the primary response elicited by B7‐1+ EL‐4 and RMA clones expressing reduced levels of ICAM‐1 is severely reduced. Furthermore, super‐transfection of ICAM‐1 cDNA into B7‐1+ adenocarcinoma and melanoma clones optimizes their primary rejection. Histologic examination of transfected tumors reveals that B7‐1 and ICAM‐1 exert a potent pro‐inflammatory activity. The intra‐tumor infiltration is composed of both eosinophils and lymphomono‐cytes, and is already massive 5 days after the tumor challenge. The primary rejection of the B7‐1+ ICAM‐1+ tumors depends critically on CD8+ T cells, natural killer cells and granulocytes, but is independent of CD4+ T cells. Remarkably, in addition to its effects on the early phases of the immune response, the co‐expression of ICAM‐1 and B7‐1 on tumors is also necessary for the efficient induction of a memory response. In fact, only the primary challenge with B7‐1+, ICAM‐1+ tumor cells protects the majority of the mice from a second injection of parental tumor cells. Collectively, our findings indicate that B7‐1 and ICAM‐1 are fundamental components for triggering the primary rejection of tumors and establishing a protective memory response. These findings may help to define new strategies for the rational application of co‐stimulation in tumor immunotherapy.
Heart rate reduction may be a major determinant of vascular tone in esmolol-treated septic shock patients-although still remains to be confirmed!

Over the last decade, the regulation of the autonomic nervous system by β1-adrenoreceptor antagonists in septic shock patients has been the subject of growing literature. In 2013, Morelli et al . published a randomized, controlled, open-label, single-center phase 2 trial investigating the efficacy of intravenous esmolol, a short acting β1-blocker titrated to lower heart rate (HR) in septic shock patients with severe tachycardia. This study found that esmolol was associated with a reduction in HR to the specified target range (80–94 bpm), maintained cardiac output, increased systemic vascular resistances along with a subsequent reduction in norepinephrine dose requirements (1).
Concordance in twins: methods and interpretation.

Monozygous (MZ) and dizygous (DZ) twins provide a unique and valuable set of material for the study of inheritance of traits and diseases in man. Yet the twin method and twin results are often not given the weight or attention they deserve. This is partly because of the variety of methods used and the different genetic interpretations made, which are sometimes inappropriate. There is need for a simple account of the twin method for clinical geneticists and other users who lack statistical expertise. The object of this paper is to present a simple, standard procedure for collecting, analyzing, and interpreting twin concordance data. The effects of factors such as common familial environment are taken into account, and other methods of analysis and interpretation are considered. Several workers [1-3] have already dealt with particular aspects of twin concordance, and the relevant results, along with some new results, are presented here.
Paternal Hamsters Mechanically Assist the Delivery, Consume Amniotic Fluid and Placenta, Remove Fetal Membranes, and Provide Parental Care during the Birth Process

We report the first description of a male mammal behaviorally participating in the birth of his young. Djungarian hamsters, Phodopus campbelli, are naturally biparental and males contribute to pup survival and growth through direct paternal care and indirect effects on maternal physiology. Males of the closely related Siberian hamster, P. sungorus, have only seasonal opportunities to interact with pups and neither contribute to pup survival and growth nor provide extensive paternal care under laboratory conditions. Male P. campbelli undergo a series of hormonal changes prior to the birth of their first litter which are not shared with P. sungorus males and may "prime" males to express paternal behavior. We hypothesized that P. campbelli males would behave paternally on first contact with pups during the birth process, whereas P. sungorus males would not. In addition to showing paternal behavior toward neonates, male P. campbelli licked amniotic fluid before the birth, mechanically assisted the delivery, opened an airway by clearing the nostrils (so that pups flushed red with oxygenation), licked and sniffed pups in the moments and minutes after birth to clean the pups of membranes, and ate the placenta. None of these behaviors were observed in P. sungorus. We anticipate that P. campbelli will not be the only species with highly developed paternal behavioral repertoires during the birth.
Comparison of random forest and long short-term memory network performances in classification tasks using radar

Robust semantic knowledge of the environment is one of the building blocks for autonomous driving. If different sensor types are employed for the same task independently, the overall accuracy and safety of the system can increase. Therefore, it is desirable to maximize each sensor's capabilities and to build up redundancies, as it is often required by functional safety. To this end, this paper demonstrates how classification of dynamic objects using solely radar sensors can be performed. Two different methods are utilized and compared: a random forest classifier and a long short-term memory network (LSTM).
Effects of different secondary vegetation types on bat community composition in Central Amazonia, Brazil

The process of secondary succession on degraded lands in the Amazon depends on their land‐use histories. In this scenario, little is known about how animal communities respond to different types of secondary vegetation in the region. We examined the effects of abandoned cattle pasture, Vismia‐ and Cecropia‐dominated regrowth on the abundance of bat species and community composition in the Central Amazon, Brazil, based on 11 netting sites and on landscape characteristics. We captured 1444 bats, representing 26 species and two families (Phyllostomidae and Mormoopidae). Among the six most‐captured Phyllostomidae bats, Sturnira lilium and Sturnira tildae had significantly higher capture rates in abandoned pasture, while Rhinophylla pumilio predominated in both Vismia‐ and Cecropia‐dominated regrowth. An hybrid multidimensional scaling ordination revealed significant differences in the bat community among the three types of secondary vegetation. Phyllostominae bats were more common and richer in the less‐disturbed areas of Cecropia‐dominated regrowth, while Stenodermatinae species were more captured in abandoned pastures. Our results suggest that the type of secondary vegetation, together with its land‐use history, affects bat community composition in the Central Amazon. The Phyllostominae subfamily (gleaning animalivores) was habitat selective and disappeared from areas experiencing constant disturbances. On the other hand, Stenodermatinae frugivorous bats often used and foraged in altered areas. We suggest that secondary vegetations in more‐advanced successional stages can be used to augment the total area protected by forest conservation units.
Flying Ad-Hoc Networks: Routing Protocols, Mobility Models, Issues

Flying Ad-Hoc Networks (FANETs) is a group of Unmanned Air Vehicles (UAVs) which completed their work without human intervention. There are some problems in this kind of networks: the first one is the communication between (UAVs). Various routing protocols introduced classified into three categories, static, proactive, reactive routing protocols in order to solve this problem. The second problem is the network design, which depends on the network mobility, in which is the process of cooperation and collaboration between the UAV. Mobility model of FANET is introduced in order to solve this problem. In Mobility Model, the path and speed variations of the UAV and represents their position are defined. As of today, Random Way Point Model is utilized as manufactured one for Mobility in the greater part of recreation situations. The Arbitrary Way Point model is not relevant for the UAV in light of the fact that UAV do not alter their course and versatility, speed quickly at one time because of this reason, we consider more practical models, called Semi-Random Circular Movement (SRCM) Mobility Model. Also, we consider different portability models, Mission Plan-Based (MPB) Mobility Model, Pheromone-Based Model. Moreover, Paparazzi Mobility Model (PPRZM). This paper presented and discussed the main routing protocols and main mobility models used to solve the communication, cooperation, and collaboration in FANET networks
ATP is involved in myocardial and vascular effects of exogenous bradykinin in ejecting guinea pig heart

Anning, Peter B. , Bernard D. Prendergast, Philip A. MacCarthy, Ajay M. Shah, Derek C. Buss, and Malcolm J. Lewis. ATP is involved in myocardial and vascular effects of exogenous bradykinin in ejecting guinea pig heart. Am. J. Physiol. 277 (Heart Circ. Physiol. 46): H818–H825, 1999. —It has recently been reported that bradykinin induces selective left ventricular (LV) relaxation in isolated guinea pig hearts via the release of nitric oxide. Exogenous bradykinin also induces vasodilation, which is only partly due to nitric oxide release. In the present study we investigated the role of adenyl purines on these bradykinin-induced effects. Isolated ejecting guinea pig hearts were studied. LV pressure was monitored by a 2-Fr micromanometer-tipped catheter. ATP concentrations were measured using a luciferin-luciferase assay. Bradykinin (1 and 100 nM) caused a progressive acceleration of LV relaxation together with a transient increase in coronary flow. These effects were inhibited by the nonselective P2 purinoceptor antagonist suramin (1 μM, n 5 6) but were unaffected by the selective P2x purinoceptor antagonist pyridoxal phosphate 6-azophenyl-28,48-disulfonic acid (1 μM, n 5 6). These myocardial and vascular effects of bradykinin were associated with increased ATP levels in coronary effluent. These data suggest that the selective enhancement of LV relaxation and rise in coronary flow induced by exogenous bradykinin involve endogenous ATP and the subsequent stimulation of P2 purinoceptors.
Progression of parkinsonism and loss of cognitive function in Alzheimer disease.

OBJECTIVE To assess the relation between parkinsonism and cognitive function in Alzheimer disease from cross-sectional and longitudinal perspectives. DESIGN Prospective cohort study with annual clinical evaluations during a 4-year period. SETTING Alzheimer disease clinic in an urban medical center. PARTICIPANTS Four hundred ten persons with clinically diagnosed Alzheimer disease. MAIN OUTCOME MEASURES Global and specific measures of cognitive function and parkinsonism. RESULTS Higher levels of parkinsonism at baseline were reliably associated with lower levels of cognitive function at baseline and with more rapid cognitive decline during the 4-year study period. However, the associations were small, with baseline parkinsonism accounting for less than 10% of the variation either in baseline cognitive function or in the rate of cognitive decline. By contrast, rates of change in parkinsonism and cognitive function were strongly correlated, with 70% or more shared variance in the rates of change in many models. The association was observed with diverse measures of cognition and parkinsonism and was not explained by demographic variables or use of neuroleptic medications. CONCLUSION In Alzheimer disease, progressive worsening of parkinsonism is more strongly associated with cognitive decline than previously recognized. Arch Neurol. 2000.
Lexical Contributions to Retention of Verbal Information in Working Memory: Event-Related Brain Potential Evidence

Abstract The present study investigated whether lexical codes contribute to retention of verbal information in working memory. We used event-related brain potentials (ERPs) recorded while participants were performing a serial recall task to show differences in brain activity during retention of words or pseudowords. The effects of lexical status and memory load (task difficulty) upon ERP activity during retention also differed, with memory load affecting ERP indices of phonological processing. The timing of the ERPs suggested that the influence of lexical status upon retention began during encoding. The contrast between ERPs in the serial recall task and in a control task with negligible memory demand indicated that the effect of lexical status in the retention interval of the memory task was specific to consciously controlled memory operations. These results support the view that lexical codes actively contribute to retention of words in working memory.
Pre-processing power traces to defeat random clocking countermeasures

We describe a pre-processing correlation attack on an FPGA implementation of AES, protected with a random clocking countermeasure that exhibits complex variations in both the location and amplitude of the power consumption patterns of the AES rounds. It is demonstrated that the merged round patterns can be pre-processed to identify and extract the individual round amplitudes, enabling a successful power analysis attack. We show that the requirement of the random clocking countermeasure to provide a varying execution time between processing rounds can be exploited to select a sub-set of data where sufficient current decay has occurred, further improving the attack. In comparison with the countermeasure's estimated security of 3 million traces from an integration attack, we show that through application of our proposed techniques that the countermeasure can now be broken with as few as 13k traces.
Correlates of cognitive development in low-birth-weight infants from low-income families.

A descriptive correlational design was used to investigate the relationship between environmental and perinatal variables and cognitive development in a sample of 30 low-birth-weight (LBW) preterm infants from low-income families. The incidence of mental or gross motor delay in this convenience sample was 20% (n = 6). Quality of home environment (Home Observation for Measurement of the Environment, Caldwell & Bradley, 1984) was significantly correlated with cognitive development as measured by the Bayley Scales of Mental Development (Mental Development Index [MDI]) (r = .54, p = 0.002). The HOME score predicted 29% of the variance (beta = .542, p = 0.002) in MDI scores. Birth weight and maternal education level were not significantly correlated with cognitive development in this sample. The correlation between the level of maternal depressive symptoms and the MDI scores of the infants approached significance at the p = 0.05 level, (r = -.35, p = 0.055). These findings demonstrate that the home environment is significant to developmental outcomes in high-risk infants. Implications for further research and nursing practice are discussed.