Miracle-dz/UniFAR-FTUs huggingface dataset:
3D geometrical assessment of femoral curvature: a reverse engineering technique.

OBJECTIVE Investigate the 2D/3D geometry of femoral curvature and femoral length using the advanced technique of computerized tomography combined with reverse engineering techniques. MATERIAL AND METHOD The present study was performed using reverse engineering technique based on CT data of 99 cadaveric femora. The femur was divided into three segments, proximal, mid-shaft, and distal regions by defining 35% and 65% of the femoral total length as a boundary of each region. The intramedullary canal in the mid-shaft region was mainly extracted to determine the set of circular center, which could consequence to approximate the 3D femoral radius of curvature using the 3D least square best fit. The 3D femoral curvature was then projected into A-P and M-L directions to investigate the correlation of 2D/3D femoral curvature as normal radiographic images. RESULTS It was found that the average 3D Thai femoral curvature was 895.46-mm (SD = 238.06) and the average femoral total length is 421.96-mm (SD = 27.61). In addition, the 2D femoral curvature derived from sagittal radiographic image can be used to determine the 3D femoral curvature with this equation: R3D = RSagittal + 3.67 with r = 0.987. CONCLUSION This described technique is a non-destructive method that can effectively assess the internal/ external 3D geometric data of the femur The obtained data is useful to develop a proper design of prosthesis that required inserting into the intramedullary canal. From the present study, it can be concluded that the 2DSagittal femoral curvature derived from standard radiographic image can be represented for the 3D femoral curvature.
Environmental News Journalism, Public Relations and News Sources

Despite professional norms and ideologies that stress journalistic autonomy, environment reporters retain close relationships with official elite sources, often at the expense of less powerful social actors. This orientation towards authority is exacerbated by the continued growth of environment public relations. The extent and nature of this development is explored in relation to communications tactics deployed by publicly-funded scientists, activists and NGOs, and a range of industry players. The chapter concludes with a consideration of the growing impacts of PR on the quality and independence of environment news in a period when journalists face unprecedented institutional and economic constraints.
PROGNOSTIC FACTORS FOR POSTOPERATIVE VISUAL OUTCOME IN SURGICALLY TREATED SUPRASELLAR MENINGIOMAS.

INTRODUCTION The prognosis of postoperative visual acuity in patients with surgically treated suprasellar meningiomas is influenced not only by the size and precise localization of meningiomas in the optochiasmatic region and their compressive effect, but also by certain parameters, such as the age of patient, duration of symptoms, and preoperative visual acuity. The purpose of this study was to analyze the influence of these factors on postoperative visual acuity in the patients with surgically treated optochiasmatic meningioma as well as to determine their prognostic value in the recovery of visual function after surgery. MATERIAL AND METHODS The study sample consisted of 43 pati- ents operated for suprasellar meningioma. All tumors were dia- gnosed by computed tomography or nuclear magnetic resonance scans. Visual acuity was analyzed both before surgery and six months after surgery. The effects of age, preoperative Visual loss, duration of visual symptoms and tumor size on visual outcome were analyzed. RESULTS Postoperative improvement of visual acuity was observed in 50% of eyes (68.4% of patients). Visual outcome was better in the younger patients. The patients with better preoperative visual acuity had better postoperative visual acuity outcome. Chances of achieving better postoperative visual function and favorable tumor resection outcome were inversely proportional to the increased length of history of disease and tumor size. CONCLUSION Postoperative visual acuity prognosis in suprasellar meningioma surgery was favorably affected by the mean duration of symptoms of less than 24 months, tumor size less than 30 mm. and preoperative visual acuity loss below 0.1.
Ectopic expression of ORANGE promotes carotenoid accumulation and fruit development in tomato

Summary Carotenoids are critically important to plants and humans. The ORANGE (OR) gene is a key regulator for carotenoid accumulation, but its physiological roles in crops remain elusive. In this study, we generated transgenic tomato ectopically overexpressing the Arabidopsis wild‐type OR (At ORWT) and a ‘golden SNP’‐containing OR (At ORH is). We found that At ORH is initiated chromoplast formation in very young fruit and stimulated carotenoid accumulation at all fruit developmental stages, uncoupled from other ripening activities. The elevated levels of carotenoids in the AtOR lines were distributed in the same subplastidial fractions as in wild‐type tomato, indicating an adaptive response of plastids to sequester the increased carotenoids. Microscopic analysis revealed that the plastid sizes were increased in both At ORWT and At ORH is lines at early fruit developmental stages. Moreover, AtOR overexpression promoted early flowering, fruit set and seed production. Ethylene production and the expression of ripening‐associated genes were also significantly increased in the AtOR transgenic fruit at ripening stages. RNA‐Seq transcriptomic profiling highlighted the primary effects of OR overexpression on the genes in the processes related to RNA, protein and signalling in tomato fruit. Taken together, these results expand our understanding of OR in mediating carotenoid accumulation in plants and suggest additional roles of OR in affecting plastid size as well as flower and fruit development, thus making OR a target gene not only for nutritional biofortification of agricultural products but also for alteration of horticultural traits.
The Emerging Immunogenetic Architecture of Schizophrenia

Schizophrenia is a severe psychiatric disorder of complex etiology. Immune processes have long been proposed to contribute to the development of schizophrenia, and accumulating evidence supports immune involvement in at least a subset of cases. In recent years, large-scale genetic studies have provided new insights into the role of the immune system in this disease. Here, we provide an overview of the immunogenetic architecture of schizophrenia based on findings from genome-wide association studies (GWAS). First, we review individual immune loci identified in secondary analyses of GWAS, which implicate over 30 genes expressed in both immune and brain cells. The function of the proteins encoded by these immune candidates highlight the role of the complement system, along with regulation of apoptosis in both immune and neuronal cells. Next, we review hypothesis-free pathway analyses which have so far been inconclusive with respect to identifying immune pathways involved in schizophrenia. Finally, we explore the genetic overlap between schizophrenia and immune-mediated diseases. Although there have been some inconsistencies across studies, genome-wide pleiotropy has been reported between schizophrenia and Crohn's disease, multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, type 1 diabetes, and ulcerative colitis. Overall, there are multiple lines of evidence supporting the role of immune genes in schizophrenia. Current evidence suggests that specific immune pathways are involved-likely those with dual functions in the central nervous system. Future studies focused on further elucidating the relevant pathways hold the potential to identify novel biomarkers and therapeutic targets for schizophrenia.
Specific Reading Comprehension Disability: Major Problem, Myth, or Misnomer?

The goal of the present study was to test three competing hypotheses about the nature of comprehension problems of students who are poor in reading comprehension. Participants in the study were first, second, and third graders, totaling nine cohorts and over 425,000 participants in all. The pattern of results was consistent across all cohorts: Less than 1 percent of first– through third–grade students who scored as poor in reading comprehension were adequate in both decoding and vocabulary. Although poor reading comprehension certainly qualifies as a major problem rather than a myth, the term specific reading comprehension disability is a misnomer: Individuals with problems in reading comprehension that are not attributable to poor word recognition have comprehension problems that are general to language comprehension rather than specific to reading. Implications for assessment and intervention are discussed.
Sauvé–Kapandji procedure with headless compression screw in patients with rheumatoid arthritis

Abstract Objective: We examined the surgical outcomes of the Sauvé–Kapandji (S–K) procedure using a headless compression screw and a metal cancellous screw in patients with rheumatoid arthritis (RA). Methods: This retrospective study included 41 RA patients who underwent the S–K procedure for distal radioulnar joint disorders with two screws: headless compression screws (HCS group, n = 20) and cannulated cancellous screws (CCS group, n = 21). Clinical and radiographic outcomes were assessed 1 year after surgery. Radiographic outcomes included bony union of the distal radioulnar joint (DRUJ), bone resorption around the screw, a screw back-out, and use of additional K-wire. We investigated any complications related to the screw head. Results: All 20 patients in the HCS group showed bone fusion of the DRUJ. In the CCS group, an asymptomatic non-union was observed in one patient and additional K-wire was needed to stabilize the DRUJ in three patients. No patients complained of any complications related to the screw head in the HCS group, while the CCS group demonstrated the hardware protrusion in two patients who complained of tenderness or discomfort at the screw head. Conclusions: The use of a headless compression screw in the S–K procedure is useful in patients with RA.
Structure of optimal martingale transport plans in general dimensions

Given two probability measures $\mu$ and $\nu$ in "convex order" on $\R^d$, we study the profile of one-step martingale plans $\pi$ on $\R^d\times \R^d$ that optimize the expected value of the modulus of their increment among all martingales having $\mu$ and $\nu$ as marginals. While there is a great deal of results for the real line (i.e., when $d=1$), much less is known in the richer and more delicate higher dimensional case that we tackle in this paper. We show that many structural results can be obtained whenever a natural dual optimization problem is attained, provided the initial measure $\mu$ is absolutely continuous with respect to the Lebesgue measure. One such a property is that $\mu$-almost every $x$ in $\R^d$ is transported by the optimal martingale plan into a probability measure $\pi_x$ concentrated on the extreme points of the closed convex hull of its support. This will be established in full generality in the 2-dimensional case, and also for any $d\geq 3$ as long as the marginals are in "subharmonic order". In some cases, $\pi_x$ is supported on the vertices of a $k(x)$-dimensional polytope, such as when the target measure is discrete. Many of the proofs rely on a remarkable decomposition of "martingale supporting" Borel subsets of $\R^d\times \R^d$ into a collection of mutually disjoint components by means of a "convex paving" of the source space. If the martingale is optimal, then each of the components in the decomposition supports a restricted optimal martingale transport for which the dual problem is attained. These decompositions are used to obtain structural results in cases where duality is not attained. On the other hand, they can also be related to higher dimensional Nikodym sets. %On the other hand, they can also lead to natural and intriguing constructions of higher dimensional Nikodym sets.
HLA class II haplotypes differentiate between the adult autoimmune polyglandular syndrome types II and III.

BACKGROUND Genetics of the adult autoimmune polyglandular syndrome (APS) is poorly understood. AIM The aim of this study was to gain further insight into the genetics of the adult APS types. SITE: The study was conducted at a university referral center. METHODS The human leukocyte antigen (HLA) class II alleles, haplotypes, and genotypes were determined in a large cohort of patients with APS, autoimmune thyroid disease (AITD), and type 1 diabetes and in healthy controls by the consistent application of high-resolution typing at a four-digit level. RESULTS Comparison of the allele and haplotype frequencies significantly discriminated patients with APS vs AITD and controls. The HLA class II alleles DRB1*03:01 *04:01, DQA1*03:01, *05:01, DQB1*02:01, and *03:02 were observed more frequently (P<.001) in APS than in AITD and controls, whereas the alleles DRB1*15:01, DQB1*03:01, and *06:02 were underrepresented in APS vs AITD (Pc<.001) and controls (Pc<.01), respectively. The DRB1*03:01-DQA1*05:01-DQB1*02:01 (DR3-DQ2) and DRB1*04:01-DQA1*03:01:DQB1*03:02 (DRB1*04:01-DQ8) haplotypes were overrepresented in APS (Pc<.001). Combination of both haplotypes to a genotype was highly prevalent in APS vs AITD and controls (Pc<.001). Dividing the APS collective into those with Addison's disease (APS type II) and those without Addison's disease but including type 1 diabetes and AITD (APS type III) demonstrated DR3-DQ2/DRB1*04:01-DQ8 as a susceptibility genotype in APS III (Pc<.001), whereas the DR3-DQ2/DRB1*04:04-DQ8 genotype correlated with APS II (Pc<.001). The haplotypes DRB1*11:01-DQA1*05:05-DQB1*03:01 and DRB1*15:01-DQA1*01:02-DQB1*06:02 are protective in APS III but not in type II (Pc<.01). CONCLUSIONS HLA class II haplotypes differentiate between the adult APS types II and III. Susceptible haplotypes favor the development of polyglandular autoimmunity in patients with AITD.
Baseline characteristics and treatment outcomes for men with acquired or lifelong premature ejaculation with mild or no erectile dysfunction: integrated analyses of two phase 3 dapoxetine trials.

INTRODUCTION Premature ejaculation (PE) is classified as an acquired or lifelong condition but data on baseline characteristics and response to treatment of men with acquired or lifelong PE and mild erectile dysfunction (ED) or normal erectile function (EF) is limited. AIM To present integrated analyses of baseline characteristics and treatment outcomes from phase 3 dapoxetine trials in men with acquired or lifelong PE and mild or no ED. METHODS Data were analyzed from two randomized, double-blind, placebo-controlled, phase 3 clinical trials (International and Asia-Pacific) that evaluated efficacy and safety of dapoxetine (30 mg or 60 mg as needed [PRN]) in patients with PE. Men were ≥18 years, in a stable monogamous relationship for ≥6 months, met DSM-IV-TR criteria for PE for ≥6 months, had an International Index of Erectile Function EF domain score ≥21, and had an intravaginal ejaculatory latency time (IELT) ≤2 minutes in ≥75% of intercourse episodes. MAIN OUTCOME MEASURES Demographics, sexual history, and PE symptomatology at baseline, and mean IELT and patient-reported outcomes (PROs) at study end (week 12), were analyzed for men with acquired or lifelong PE and mild or no ED (EF score 21-25 vs. ≥26). RESULTS Baseline characteristics except duration of PE were similar in men with acquired and lifelong PE, with no other differentiating features by ED status. Dapoxetine treatment improved significantly mean IELT (arithmetic and geometric) and PRO responses (perceived control over ejaculation, satisfaction with sexual intercourse, ejaculation-related personal distress, and interpersonal difficulty) for acquired and lifelong subtypes, but presence of mild ED diminished PRO responsiveness in both subtypes, particularly those with lifelong PE. CONCLUSIONS Baseline characteristics and treatment outcomes were generally similar in men with acquired and lifelong PE. The presence of mild ED appears to be associated with a more modest treatment response, irrespective of lifelong or acquired PE subtype.
Particle image velocimetry and visualization of natural and forced flow around rectangular cylinders

Particle image velocimetry (PIV) measurements and flow visualization in a water tunnel show that vortex shedding at the leading and trailing edges of rectangular cylinders can be simultaneously phase-locked to transverse velocity perturbations when the applied perturbation Stp is close to an impinging leading-edge vortex/trailing-edge vortex shedding (ILEV/TEVS) frequency. The transverse perturbations, analogous to β-mode duct acoustic resonances, are generated through harmonic oscillations of the sidewalls. When this occurs, the leading-edge vortices are found always to pass the trailing edge at the same phase in the perturbation cycle regardless of the chord-to-thickness (c/t) ratio. Applying perturbations at an Stp not equal to the natural global frequency also results in phase-locked vortex shedding from the leading edge, and a near wake with a frequency equal to the perturbation frequency. This is consistent with previous experimental findings. However, vortex shedding at the trailing edge is either weaker or non-existent. PIV results and flow visualization showed trailing-edge vortex growth was weaker because leading-edge vortices arrive at the trailing edge at a phase in the perturbation cycle where they interfere with trailing-edge shedding. The frequencies at which trailing-edge vortices form for different c/t ratios correspond to the natural ILEV/TEVS frequencies. As in the case of natural shedding, peaks in base suction occur when the leading-edge vortices pass the trailing edge at the phase in the perturbation cycle (and thus in the leading-edge shedding cycle) that allows strong trailing-edge shedding. This is the reason for the similarity in the St vs. c/t relationship for three seemingly different sets of experiments.
Distinguishing between irritated seborrheic keratosis and squamous cell carcinoma in situ using BCL‐2 and IMP3 immunohistochemistry

Distinguishing an irritated seborrheic keratosis (ISK) from a squamous cell carcinoma in situ (SCCIS) can occasionally be challenging, both histologically and clinically. The purpose of this study was to determine if an immunohistochemical profile of select markers can aid in differentiating these two entities.
Flavonoids of Rosa roxburghii Tratt act as radioprotectors.

BACKGROUND To study the radioprotective effects of flavonoids from Rosa roxburghii Tratt (FRT). MATERIALS AND METHODS The radioprotective effects of FRT were investigated by examining cell viability, 30-day survival of mice and the number of colony-forming units in spleen (CFU-S) after total-body 60Co irradiation. RESULTS The survival rates of irradiated cells gradually increased with increasing concentrations of FRT. The survival rate was the highest at 87% with a concentration of 30 μg/mL. Pretreatment with FRT was needed to realize its radioprotective activity in mice at the dose of 60 mg/kg. With the increasing doses of 30 mg/kg, 60 mg/kg and 120 mg/kg, the numbers of CFU-S increased, and were significantly different compared with the control group. CONCLUSIONS Pretreatment with FRT prior to irradiation resulted in significantly higher cell survival at 24 h after 5 Gy radiation, increased 30-day survival in mice after exposure to a potentially lethal dose of 8 Gy, and resulted in a higher number of CFU-S in mice after exposure to a dose of 6 Gy. These results collectively indicate that FRT is an effective radioprotective agent.
The Di Bella Method (DBM) improved survival, objective response and performance status in a retrospective observational clinical study on 55 cases of lymphomas.

OBJECTIVES Lymphomas are the main form of haematological neoplasms, representing 55.6% of all tumours of the blood. Overall, they account for 5.3% of all malignant tumours (excluding basal and squamous cell skin cancer) in Italy with a prevalence constantly increasing at a rate of 3% per year. From a histological point of view, they represent a vast heterogeneous group of haematological diseases, their staging being based on defined cyto-morphological and anatomo-pathological criteria. Although the combined use of standard approaches can provide good response rates, recurrence is particularly frequent in patients undergoing traditional treatment, with critical and often irreversible side effects such as myelosuppression and a high frequency of opportunistic infections and sterility. Numerous epidemiological studies and preclinical data have for some time now reported the anticancer effects of molecules such as Melatonin, Retinoids, Vitamins E, D3, and C, Somatostatin and prolactin inhibitors in neoplastic diseases. There are, however, very few publications on the combined effects of these substances in vivo. METHODS We report an observational study carried out on 55 patients affected by various forms of lymphoma, treated with the biological therapy known as the Di Bella Method (DBM). The 1, 3 and 5-year survival rates are reported, together with any signs of toxicity. RESULTS The DBM treatment achieved partial or complete objective responses in a shorter time and in greater percentages if administered as first-line therapy. The adjuvant treatment increased survival time and improved quality of life with respect to the data reported in the literature for the same types and stages of lymphoma. CONCLUSION Overall, the treatment was well tolerated, with minor and transient side effects. The patients were able to continue the treatment at home, carrying out their normal activities without problems.
The association between cervical abnormalities and attitudes toward cervical cancer prevention.

BACKGROUND We investigated whether a history of cervical abnormalities predicts responses to cervical cancer prevention for women and their daughters. METHODS In 2007, we interviewed 832 mothers of adolescent daughters from North Carolina counties with elevated rates of cervical cancer. We measured the association of experiences with cervical abnormalities and emotions, beliefs, attitudes, and behaviors related to cervical cancer and its prevention. RESULTS Anxiety about cervical cancer was higher among women who had cervical cancer, hysterectomies, and abnormal Pap test results (including false positives) than in women who had experienced none of these (each p < 0.05). Pap tests were perceived as being more effective at reducing the chance of developing cervical cancer by women with a history of cancer and women who reported hysterectomies relative to women with normal Pap results (each p < 0.05). Intentions to vaccinate their daughters against human papillomavirus (HPV) were highest among women who had cervical cancer, women who had hysterectomies, and women who were treated for precancerous lesions (each p < 0.05). CONCLUSIONS Women with histories of cervical health abnormalities reported more favorable views of Pap testing and HPV vaccination than women who had received only normal Pap testing results. They also reported higher levels of anxiety about cervical cancer.
Probability Distributions of Assets Inferred from Option Prices via the Principle of Maximum Entropy

This article revisits the maximum entropy algorithm in the context of recovering the probability distribution of an asset from the prices of finitely many associated European call options via partially finite convex programming. We are able to provide an effective characterization of the constraint qualification under which the problem reduces to optimizing an explicit function in finitely many variables. We also prove that the value (or objective) function is lower semicontinuous on its domain. Reference is given to a website which exploits these ideas for the efficient computation of the maximum entropy solution (MES).