Miracle-dz/UniFAR-FTUs huggingface dataset:
Ambulatory transradial percutaneous coronary intervention: A safe, effective, and cost‐saving strategy

Objectives: The aim of this prospective, multicenter study was to assess the safety, feasibility, acceptance, and cost of ambulatory transradial percutaneous coronary intervention (PCI) under the conditions of everyday practice. Background: Major advances in PCI techniques have considerably reduced the incidence of post‐procedure complications. However, overnight admission still constitutes the standard of care in most interventional cardiology centers. Methods: Eligibility for ambulatory management was assessed in 370 patients with stable angina referred to three high‐volume angioplasty centers. On the basis of pre‐specified clinical and PCI‐linked criteria, 220 patients were selected for ambulatory PCI. Results: The study population included a substantial proportion of patients with complex procedures: 115 (52.3%) patients with multivessel coronary artery disease, 50 (22.7%) patients with multilesion procedures, and 60 (21.5%) bifurcation lesions. After 4‐6 hr observation period, 213 of the 220 patients (96.8%) were cleared for discharge. The remaining seven (3.2%) patients were kept overnight for unstable angina (n = 1), atypical chest discomfort (n = 2), puncture site hematoma (n = 1), or non‐cardiovascular reasons (n = 3). Within 24 hr after discharge, no patients experienced readmission, stent occlusion, recurrent ischemia, or local complications. Furthermore, 99% of patients were satisfied with ambulatory management and 85% reported no anxiety. The average non‐procedural cost was lower for ambulatory PCI than conventional PCI (1,230 ± 98 Euros vs. 2,304 ± 1814 Euros, P < 10−6). Conclusions: Ambulatory PCI in patients with stable coronary artery disease is safe, effective, and well accepted by the patients. It may both significantly reduce costs and optimize hospital resource utilization. © 2012 Wiley Periodicals, Inc.
Central motor drive is increased during voluntary muscle contractions in multiple sclerosis

To test the hypothesis that central motor drive is increased during voluntary contractions in multiple sclerosis (MS) patients, we recorded the surface electromyogram (EMG) and force from the tibialis anterior muscle during isometric dorsiflexion in 14 MS and 18 control subjects. Measurements were obtained during contractions at 10–100% of maximal voluntary contraction (MVC), incremented by 10% MVC. Integrated EMG (% maximum) was elevated in MS compared to controls from 10 to 70% MVC (pairwise, P < 0.05; main effect, P = 0.001). MS severity (Expanded Disability Status Scale) was highly correlated to the individual slopes of the EMG/force relationship (r = −0.87, P < 0.001). We conclude that central motor drive in MS is increased throughout a large range of submaximal contractions and that this increase is associated with overall disease severity. © 1997 John Wiley & Sons, Inc. Muscle Nerve 20: 1213–1218, 1997
Visual outcomes following lensectomy and vitrectomy for combined anterior and posterior persistent hyperplastic primary vitreous.

OBJECTIVE To determine the visual outcome after surgery for persistent hyperplastic primary vitreous using modern vitreoretinal techniques. DESIGN Retrospective medical record review during a 5-year period (June 1992 to June 1997). Information recorded for each patient included age, medical history, sex, results of preoperative ocular examination, age at diagnosis, procedure performed, intraoperative and postoperative complications, location and number of sclerotomy sites, type of aphakic rehabilitation, amblyopic therapy given, final visual acuity, and length of follow-up. RESULTS Fourteen patients who underwent surgical management of combined anterior and posterior persistent hyperplastic primary vitreous were identified. Eleven patients underwent aphakic rehabilitation and aggressive amblyopic therapy consisting of occlusive therapy for several waking hours each day. One additional older patient received aphakic rehabilitation only. Ten eyes (71%) achieved a visual acuity of 20/300 or better, and 8 (57%) obtained a final visual acuity of 20/100 or better. Average length of follow-up was 22 months (range, 4-57 months). Nine patients were fitted with an aphakic soft contact lens, 2 older patients had a posterior chamber intraocular lens placed at the time of vitrectomy, and 1 patient wore aphakic spectacles. CONCLUSIONS With modern vitreoretinal techniques, aphakic rehabilitation, and aggressive amblyopic therapy, useful vision can be obtained in the majority of patients with combined anterior and posterior persistent hyperplastic primary vitreous.
PENGARUH TINGKAT BONUS SBIS DAN TINGKAT INFLASI TERHADAP PENYALURAN PEMBIAYAAN BANK SYARIAH DI INDONESIA

This study was conducted to examine and analyze the influence Bonus of Bank Indonesia Sharia Certificates and the rate of inflation to the Distribution Financing Islamic Bank in Indonesia in the period 2008-2012. The data used in this research was secondary data from 2008 to 2012. The data were analysed using multiple linear regression. Based on the research results, there is a strong and negative influence Bonus of Bank Indonesia Sharia Certificates to the rate of inflation to the Distribution Financing Islamic Bank in Indonesia . There is also no significant difference between the negative and the level of inflation related to the distribution of financing Islamic Bank in Indonesia. This means that if Bonus SBIS and inflation rises, the Islamic bank financing will go down. Penelitian ini dilakukan untuk menguji dan menganalisis pengaruh Bonus Sertifikat Bank Indonesia Syariah (SBIS) dan tingkat Inflasi terhadap Penyaluran Pembiayaan Bank Syariah di Indonesia pada periode 2008-2012. Data yang digunakan dalam penelitian ini adalah data sekunder dengan kurun waktu tahun 2008 sampai dengan tahun 2012, dan metode analisis data yang digunakan adalah regreai linear berganda. Dimana X1 adalah Bonus Sertifikat Bank Indonesia Syariah (SBIS), X2 adalah tingkat Inflasi dan Y adalah Penyaluran Pembiayaan Bank Syariah di Indonesia. Berdasarkan hasil penelitian, terdapat bepengaruh kuat dan negatif antara Bonus Sertifikat Bank Indonesia Syariah terhadap Penyaluran Pembiayaan Bank Syariah di Indonesia dan juga tidak terdapat pengaruh yang signifikan dan berhubungan negatif antara tingkat Inflasi terhadap Penyaluran Pembiayaan Bank Syariah di Indonesia. Artinya apabila Bonus SBIS dan Inflasi naik maka pembiayaan bank syariah akan turun.
Women empowerment in sports: An analysis of the sports coverage of leading newspapers in Bengal with respect to Rio Olympic

Purpose: Several studies reported about existence of gender disparity in the sports content of print media around the world. The purpose of the research was to find out whether both female and male athletes of India participated in Rio Olympic had received same importance in sports coverage in print media or not. Methodology: For this purpose the content of the sports coverage related with Rio Olympic in Newspapers on and from 3th August to 23th August 2016 were analyzed from the angle of gender inequality in sports news publication. Ten leading daily newspapers on Bengali and English published in Kolkata, West Bengal were considered for this study. Variables considered in this study were area covered for total news (ACTN) and area covered for photograph (ACPH). Measurement was done by calculating the area in Sq. Cm. of the newspaper using simple geometric scale. Mean and standard deviation was used as descriptive statistics and t-test was used for comparison between the male and female athletes’ sports coverage. All statistical calculations were done using standard statistical software (Excel, 2010). Only 0.05 level of significance was considered for the present study. Results: Results revealed that mean values of ATCN and ACPH for female athletes were higher than the male athletes. Calculated t-values for ATCN (t =2.81) and ACPH (t=2.44) has found statistically significant. Conclusion: From above results it was concluded that female athletes received significantly higher coverage in news writing and pictorial section than the male athletes of Rio Olympic. These findings may be considered as women empowerment in Indian sports scenario.
Intensive Care Unit Admission With Community-Acquired Pneumonia

Background:There has been a dramatic increase in the use of intensive care units (ICUs) over the past 25 years. Greater use of validated measures of illness severity may better inform ICU admission decisions in patients with community-acquired pneumonia. This article examined predictors of ICU admission and hospitalization costs, including the pneumonia severity index (PSI) and CURB-65 (confusion, uremia, respiratory rate, blood pressure, age ≥65 years) scores. Methods:The study identified 422 patients hospitalized for community-acquired pneumonia, ascertaining patient characteristics by chart review and extraction of administrative data. Multivariate logistic regression was performed to quantify the association of the PSI, CURB-65 and comorbidities with ICU admission. The predictors of cost were estimated using a generalized linear model. Results:Compared to 194 general medicine patients, certain clinical and radiographic findings were more common among 228 ICU patients. Compared to PSI reference group I/II/III, ICU admission was strongly associated with risk class IV (odds ratio [OR], 3.06; 95% confidence interval [CI], 1.63–5.72) and V (OR, 4.84; CI, 2.44–9.62), and also CURB-65 ≥3 (OR, 2.90; CI, 1.51–5.56). The relative increase in mortality among PSI risk class V (compared to IV) patients was 2.68 times higher in general medicine, compared with the ICU. Among ICU admissions, risk class V was associated with an additional cost of $14,548 (95% CI, $4,232 to $24,864). Conclusions:Illness severity and chronic pulmonary disease are strong predictors of ICU admission. More extensive use of the PSI may optimize site-of-care decisions, thereby minimizing mortality and unnecessary resource utilization.
Determinants of Exercise and Aerobic Fitness in Outpatients with Arthritis

Factors that influenced exercise behaviors and aerobic fitness were identified in 100 outpatients with rheumatoid arthritis or osteoarthritis. Data included perceived health status, benefits of and barriers to exercise, and impact of arthritis on health; demogaphic and biologic characteristics; and past exercise behavior. Excercise measures included range-of-motion and strengthening exerises, 7-day activity recall, and the exercise subscale of the Health-Promoting Lifestyle Profile. An aerobic fitness level was obtained on each subject by bicycle ergometer testing. The theoretical model predicted 20% of the variance in composite exercise scores but none of the variance in aerobic fitness levels. Perceived benefits of exercise was a significant predictor of exercise participation. Subjects with less formal education, longer duration of arthritis, and bigher impact of arthritis scores perceived fewer benefits of exercise, while subjects who reported exercising in their youth perceived more benefits of exercise.
Vaginal symptoms in Japanese postmenopausal women:comparison with other climacteric symptoms

Objectives This study was designed to investigate the current status of vaginal symptoms in Japanese postmenopausal women, and to clarify the significance of vaginal symptoms by analyzing their relationship to other climacteric symptoms. Methods The complaints of 613 women attending a menopause clinic (mean age ± standard deviation 53.5 ± 7.2 years; time since menopause or bilateral oophorectomy 6.4 ± 6.5 years) were evaluated according to the Keio modified menopause index. Results In total, 56.4% of subjects had at least one vaginal symptom. The most frequent vaginal symptom was dyspareunia, followed by vaginal dryness, discharge and itching, and the mean prevalence of the four symptoms was 31.7%. The peak intensity of vaginal symptoms occurred in the sixth decade, or 3–5 years after menopause or oophorectomy. Vaginal symptoms were usually associated with other climacteric symptoms, but some occurred independently. Conclusions A moderate proportion of Japanese postmenopausal women experience vaginal symptoms, which can occur independently of other climacteric symptoms. Vaginal symptoms therefore warrant careful attention during the treatment of postmenopausal women.
Early experience with two‐dose daclizumab in the prevention of acute rejection in cardiac transplantation

Abstract: Background: Daclizumab is a human monoclonal antibody that binds to the interleukin‐2 receptor. It has been used as induction therapy in heart transplantation with repeated administrations over several weeks. At our institution, we use a two‐dose regimen of daclizumab based on its extended half‐life. We sought to determine the incidence of acute rejection with 2‐dose daclizumab in cardiac transplantation.
Time limit and time at VO2max' during a continuous and an intermittent run.

BACKGROUND The purpose of this study was to verify, by track field tests, whether sub-elite runners (n=15) could (i) reach their VO2max while running at v50%delta, i.e. midway between the speed associated with lactate threshold (vLAT) and that associated with maximal aerobic power (vVO2max), and (ii) if an intermittent exercise provokes a maximal and/or supra maximal oxygen consumption longer than a continuous one. METHODS Within three days, subjects underwent a multistage incremental test during which their vVO2max and vLAT were determined; they then performed two additional testing sessions, where continuous and intermittent running exercises at v50%delta were performed up to exhaustion. Subject's gas exchange and heart rate were continuously recorded by means of a telemetric apparatus. Blood samples were taken from fingertip and analysed for blood lactate concentration. RESULTS In the continuous and the intermittent tests peak VO2 exceeded VO2max values, as determined during the incremental test. However in the intermittent exercise, peak VO2, time to exhaustion and time at VO2max reached significantly higher values, while blood lactate accumulation showed significantly lower values than in the continuous one. CONCLUSIONS The v50%delta is sufficient to stimulate VO2max in both intermittent and continuous running. The intermittent exercise results better than the continuous one in increasing maximal aerobic power, allowing longer time at VO2max and obtaining higher peak VO2 with lower lactate accumulation.
Makerspaces and Local Economic Development

The maker movement has risen from a fringe hobby to a prominent lifestyle with important implications for economic development. In the past, tools have been available only to those working in firms and industry or those willing to pay for their procurement. The maker movement increases access to tools and training, potentially altering the capability of the general public to participate in product development. This study explores makerspaces and how they contribute to economic development through business generation and sustainment. Based on interviews with members and the management of makerspaces, along with local government officials in Georgia, the author finds four principal contributions to economic development: (a) creating a cultural change by encouraging entrepreneurship in the community, (b) supporting small business growth through the provision of services, (c) providing workforce training, and (d) increasing workforce retention. However, in part because of their recent development and small memberships, makerspaces are unlikely to launch many entrepreneurs into their communities anytime soon. As such, governments should avoid making excessive commitments to makerspaces before they provide greater evidence of tangible contributions, but allowing them an expanded role in formal education can enhance their ability to incubate a â€œmakerâ€ mind-set.
Hepatitis B and C virus infection among hemodialysis patients in yogyakarta, Indonesia: Prevalence and molecular evidence for nosocomial transmission

Hemodialysis patients are at an increased risk of acquiring hepatitis B virus (HBV) and hepatitis C virus (HCV) infection. However, the prevalence of hepatitis viral infection and its genotype distribution among hemodialysis patients in Indonesia are unclear. In order to investigate these issues and the possibility of nosocomial transmission, 161 hemodialysis patients and 35 staff members at one of the hemodialysis unit in Yogyakarta, Indonesia, were tested for serological and virological markers of both viruses. HBV surface antigen (HBsAg) was detected in 18 patients (11.2%) and in two staff members (5.7%). Anti‐HCV was detected in 130 patients (80.7%) but not in any staff members. Occult HBV and HCV infection were detected in 21 (14.7%) and 4 (12.9%) patients, respectively. The overall prevalence rates of HBV and HCV infection among patients were 24.2% and 83.2%, respectively. HCV infection was independently associated with hemodialysis duration and the number of blood transfusions. Phylogenetic analysis revealed that 23 of 39 tested HBV strains (59%) were genotype B, 11 (28.2%) were genotype C, and 5 (12.8%) were genotype A. HCV genotype 1a was dominant (95%) among 100 tested HCV strains. Nosocomial transmission was suspected because the genotype distribution differed from that of the general population in Indonesia, and because the viral genomes of several strains were identical. These findings suggest that HBV and HCV infection is common among hemodialysis patients in Yogyakarta, and probably occurs through nosocomial infection. Implementation of strict infection‐control programs is necessary in hemodialysis units in Indonesia. J. Med. Virol. 85:1348–1361, 2013. © 2013 Wiley Periodicals, Inc.
Use of genotyping by sequencing data to develop a high‐throughput and multifunctional SNP panel for conservation applications in Pacific lamprey

Next‐generation sequencing data can be mined for highly informative single nucleotide polymorphisms (SNPs) to develop high‐throughput genomic assays for nonmodel organisms. However, choosing a set of SNPs to address a variety of objectives can be difficult because SNPs are often not equally informative. We developed an optimal combination of 96 high‐throughput SNP assays from a total of 4439 SNPs identified in a previous study of Pacific lamprey (Entosphenus tridentatus) and used them to address four disparate objectives: parentage analysis, species identification and characterization of neutral and adaptive variation. Nine of these SNPs are FST outliers, and five of these outliers are localized within genes and significantly associated with geography, run‐timing and dwarf life history. Two of the 96 SNPs were diagnostic for two other lamprey species that were morphologically indistinguishable at early larval stages and were sympatric in the Pacific Northwest. The majority (85) of SNPs in the panel were highly informative for parentage analysis, that is, putatively neutral with high minor allele frequency across the species’ range. Results from three case studies are presented to demonstrate the broad utility of this panel of SNP markers in this species. As Pacific lamprey populations are undergoing rapid decline, these SNPs provide an important resource to address critical uncertainties associated with the conservation and recovery of this imperiled species.
Cilostazol Enhances Casein Kinase 2 Phosphorylation and Suppresses Tumor Necrosis Factor-α-Induced Increased Phosphatase and Tensin Homolog Deleted from Chromosome 10 Phosphorylation and Apoptotic Cell Death in SK-N-SH Cells

This study shows the signaling pathway by which cilostazol suppresses tumor necrosis factor-α (TNF-α)-induced the phosphatase and tensin homolog deleted from chromosome 10 (PTEN) phosphorylation and apoptosis via casein kinase 2 (CK2) phosphorylation in the SK-N-SH cells (neuroblastoma cells). Cilostazol (10 μM) fully restored cell proliferation with suppression of DNA fragmentation induced by TNF-α and emodin, a CK2 inhibitor, which were antagonized by iberiotoxin, a maxi-K channel blocker. Under application of TNF-α or emodin, increased PTEN phosphorylation and decreased phosphorylation of CK2/Akt/cyclic AMP response element-binding protein (CREB), and CK2 activity were significantly reversed by cilostazol (∼1-100 μM), all of which were antagonized by iberiotoxin. 1,3-dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one (NS-1619) and (3S)-(+)-(5-chloro-2-methoxyphenyl-1,3-dihydro-3-fluoro-6-(trifluoromethyl)-2H-indol-2-one (BMS 204352) maxi-K channel openers significantly elevated CK2 activities that were reversible by iberiotoxin. SK-N-SH cells treated with antisense CK2 oligodeoxynucleotide showed a prominent DNA fragmentation with little responsiveness to TNF-α in the phosphorylation of PTEN, indicative of the essential role of p-CK2/CK2 in cell proliferation, and the decreased cell viability of these cells was not restored by cilostazol. It is suggested that the action of cilostazol promoting cell survival is ascribed to the maxi-K channel opening-coupled up-regulation of CK2 phosphorylation and down-regulation of PTEN phosphorylation with resultant increased phosphorylation of Akt and CREB.
Intermediate uveitis in children and young adults: differences in clinical course, associations and visual outcome

Aim Intermediate uveitis (IU) is considered to carry a considerable risk for complications and visual loss. This study compares juvenile and adult onset IU with regard to visual loss and complications. Methods Single-centre retrospective analysis of 110 consecutive children with onset of IU at the age of ≤16 years compared with 107 consecutive adult patients (17–35 years). All patients were followed for ≥1 year (mean 2.5±2.3 years). Results Average age at first uveitis diagnosis in children (65 boys; 59%) was 9.7±3.17 years and in adults was 24.3±4.92 years (36 men; 34%; p=0.003). Best-corrected visual acuity (BCVA) in both groups was similar at first and last presentation. Compared with initial presentation, BCVA improved in 31% of children and 21% of adults during the follow-up period, while it worsened in 9% and 8.7%, respectively. Lyme disease in children (8%) and multiple sclerosis in adults (17%) were the most frequent systemic associations. Poor visual acuity at first presentation, snowbanks and vitreoretinal traction were associated with a higher risk for poor BCVA at last presentation. In children, cataract formation (OR 7.6; 95% CI 1.7 to 33.8) and macular oedema (13.6; 1.6 to 113.5) and in adults posterior synechiae (7.3; 1.8 to 30.2), cataract formation (19.02; 2.31 to 156.56), macular epiretinal membrane (5.1; 1.02 to 25.28) and retinal detachment (8.4; 1.4 to 51.2) were associated with poor BCVA during follow-up. Uveitis course was not worse if associated systemic disease was present. Conclusions IU with onset in childhood and early adulthood showed a similar visual course at intermediate follow-up. Associated diseases and complication patterns differed between children and young adults.