Miracle-dz/UniFAR-FTUs huggingface dataset:
The preanalytical influence of two different mechanical transport systems on laboratory analysis

In hospitals, mechanical transport systems are regularly installed to expedite and simplify transport processes. They can also be used for the conveyance of blood samples from wards or entrance portals to laboratory facilities. It was reported that mechanical transport systems can reduce turnaround times from blood collection to the report of final analytical results (1, 2), and additionally, contribute to save personnel due to a reduction in courier transport (3). The university hospital building of Wuerzburg was newly constructed (opened 2009) and equipped with two different modern transport systems: a slowly moving track vehicle system (TVS; a kind of box conveyor system, Swisslog-Telelift GmbH, Puchheim, Germany) and a rapid pneumatic tube system (PTS; Swisslog Rohrpostsysteme GmbH, Westerstede, Germany). It was our aim to test these technical systems for accuracy and safety before bringing them into service, as strong acceleration, deceleration, shaking of blood samples or changes in temperature might cause preanalytical interference. For this purpose, we compared the results of laboratory analysis after posting with the two transport systems with the results obtained after careful courier transport (CT). We chose the most sensitive and most important parameters of our laboratory (Table 1). Our study was approved by the local Ethics Committee of the University of Wuerzburg and informed consent was provided by all volunteers according to the Declaration of Helsinki. Blood tubes (standard EDTA, gel-barrier, and citrated tubes, Sarstedt AG & Co., Nuembrecht, Germany) were sent
Anticipated versus actual reaction to HIV test results.

The accuracy of predictions of how people will react to a medical test result is important because it may influence the decision to be tested. We hypothesized that people would overpredict their own long-term reactions to HIV test results (i.e., that they would feel better in response to seropositive results and worse in response to negative results than they expected to). In the first study phase, anticipations of reactions to positive and negative HIV test results were obtained from 50 subjects. In the second phase, postresult reactions were obtained about 5 weeks after subjects learned the results of their tests. The results suggest that people anticipate more distress given a positive result and anticipate less distress given a negative result than they experience. Cautions about the comparability of the 2 samples and recommendations for further research are discussed.
Preoperative diagnosis of primary fallopian tube carcinoma.

INTRODUCTION Transvaginal color and pulsed Doppler can detect areas of neovascularization within the tubal carcinoma and can distinguish it from other benign adnexal pathology. SUBJECTS AND METHODS. During a 7-year period eight cases of Fallopian tube carcinoma were detected using transvaginal color and pulsed Doppler. RESULTS Transvaginal sonography revealed complex, sausage-shaped, and/or cystic structures in the adnexal region. Additional color Doppler examination depicted low vascular impedance (RI ranged from 0.29 to 0.40). Histopathology reported different types of Fallopian tube carcinoma. CONCLUSION Transvaginal color Doppler may aid in diagnosis of Fallopian tube malignancy more reliably than using other costly diagnostic procedures.
The Joint Effects of Ex Ante Contractual Completeness and Ex Post Governance on Compliance in Franchised Marketing Channels

This study examines the heretofore neglected joint effects of ex ante contractual completeness and ex post governance on compliance in a franchise setting. In contrast to much of the extant literature that views contractual completeness in the aggregate, the present research disaggregates contractual completeness into ex ante monitoring and enforcement completeness, and additionally distinguishes between ex post monitoring and enforcement, allowing for a nuanced examination of the joint effects of different types of ex ante and ex post governance on compliance. Additionally, the authors advance the concept of consummate compliance, thereby complementing the literature, which tends to view compliance solely in terms of perfunctory compliance—an important distinction because the results suggest that perfunctory compliance has a negative relationship with customer satisfaction, whereas consummate compliance has a positive one. Drawing on multiple data sources, the authors demonstrate that ex ante monitoring completeness positively moderates the relationship between ex post monitoring and both types of compliance; however, ex ante enforcement completeness negatively moderates the relationship between ex post enforcement and both types of compliance.
Is previous aberrant reproductive outcome predictive of subsequently reduced fecundity?

BACKGROUND Effect of past reproductive performance on subsequent fecundity is uncertain. METHODS A total of 2983 consecutive pregnant women self-completed questionnaires about time to pregnancy (TTP), pregnancy planning, previous pregnancies, contraceptive use, age, and individual/lifestyle variables. Outcome measures were: TTP, conception rates (CR) and, subfecundity odds ratio (OR; with 95% confidence intervals) before and after each outcome of last pregnancy. RESULTS After miscarriage, TTP was longer than before miscarriage [2.1 (1.4-3.0), P < 0.001] and than TTP after livebirth [OR = 2.1 (1.6-2.6), P < 0.001]. Also subfecundity OR after miscarriage increased [1.7 (1.2-2.4), 1.8 (1.2-2.5), P = 0.001, 0.002 respectively]. This effect was more evident in older and obese women. Compared with livebirth, time to ectopic pregnancy (EP) was longer [OR = 13.8 (1.8-108.5), P = 0.001] but TTP after EP was not significantly different. Subfecundity OR relative to livebirth were 12.8 (3.6-45.0) (P<0.001) before, and 3.9 (1.4-11.0) (P=0.01) after, EP. The CR after EP increased 3-fold (1.1-8.3) over those prior to EP. Time to the terminated pregnancies even without contraceptive failures was shorter than that to livebirth [OR = 0.5 (0.3-0.7), P = 0.001] and than TTP after termination [0.35 (0.1-0.8), P = 0.001]. Also subfecundity OR increased after termination [7.2 (1.8-29.7), P = 0.02]. CONCLUSIONS Miscarriers should be counselled about short-term reduction in subsequent fecundity, and earlier investigations should be considered in those who have other potential risk factors for reduced fertility. Further studies are required to clarify the relatively favourable effect on fecundity following EP and the relative reduction in fecundity after termination of pregnancy.
PNIF measurement in a healthy French population. A prospective study about 234 patients.

OBJECTIVE A prospective study in a healthy French population to evaluate the normal range of PNIF. MATERIAL AND METHODS In total, 234 subjects separated into 2 groups (group 1: patients with VAS >or= 8, n = 151 and group 2: patients with VAS < 8, n = 83) have been prospectively enrolled in this study from September 2003 to April 2004. For all participants, nasal obstruction was evaluated through a VAS and two PNIF measurements. RESULTS The mean PNIF measurements in group 1 and group 2 were 87.5 L/min and 84.7 L/min, respectively with a significant difference between male and female in both groups (p < 0.0001). The reproducibility in group 1 and group 2 was 5.1 L/min and 4.4 L/min respectively. A slight tendency to a reduction due to the age was observed except for patients over 60. CONCLUSION This study confirms that the technique of PNIF measurement is reliable and simple. The normal range of PNIF in a healthy French population has been determined although our results show lower values than previous published reports from other countries. However, it remains an attractive method for the follow-up and survey of patients complaining of nasal obstruction.
Matrix metalloproteinase-8 concentration in shallow crevices associated with the extent of periodontal disease.

OBJECTIVE The aim of this study was to analyse the association between matrix metalloproteinase-8 (MMP-8) concentration in shallow, mostly non-bleeding gingival crevices, and the extent of periodontal disease. MATERIAL AND METHODS Plaque, bleeding on probing (BOP), probing pocket depth (PPD) and attachment level (AL) were assessed clinically in 48 patients with chronic periodontitis. MMP-8 concentrations in gingival crevicular fluid (GCF) from four shallow (PPD<or=3 mm), and four diseased sites and in serum, were measured by enzyme-linked immunosorbent assay. RESULTS The mean concentration of MMP-8 in GCF from shallow crevices was 11.8 +/- 12.8 ng/ml and from diseased sites was 150.1 +/- 91.8 ng/ml. In subjects with moderate to high plaque scores, a statistically significant association was found between MMP-8 concentration from shallow crevices and the extent of AL>or=4 mm (p=0.028) and AL>or=6 mm (p<0.001). CONCLUSION The above association between MMP-8 concentration in shallow crevices and attachment loss provides a new aspect to future studies of MMP-8 as a prognostic marker for periodontal disease.
THE IMPACT OF ACQUISITION ON ACQUIRER COMPANIES' FINANCIAL PERFORMANCE

Acquisition is believed as a strategy to improve performance of a company. However, several previous researches shows that acquisition can not improve the performance. The purpose of this study is to examine the impact of acquisition on acquirer companies’ financial performance. The population of this study is 21 Indonesian companies that involved in acquisition during 2011-2013. The data is financial ratios, collected from Indonesian Capital Market Directory provided by Indonesian Stock Exchange website. To analyse the performance, five ratios are used in this research. Paired sample t-test is applied on the ratios with the help of statistical software called PASW (Predictice Analytics Software). The findings confirm that liquidity, leverage, efficiency, profitability, and market value decrease insignificantly a year after acquisition. Therefore, it is concluded that there is no different in financial performance before and after acquisition. Keywords: Acquisition, acquirer companies, financial performance, financial ratios
Cutaneous exposure scenarios for engineered nanoparticles used in semiconductor fabrication: a preliminary investigation of workplace surface contamination

Abstract Background: Numerous studies are ongoing in the fields of nanotoxicology and exposure science; however, gaps remain in identifying and evaluating potential exposures from skin contact with engineered nanoparticles in occupational settings. Objectives: The aim of this study was to identify potential cutaneous exposure scenarios at a workplace using engineered nanoparticles (alumina, ceria, amorphous silica) and evaluate the presence of these materials on workplace surfaces. Methods: Process review, workplace observations, and preliminary surface sampling were conducted using microvacuum and wipe sample collection methods and transmission electron microscopy with elemental analysis. Results: Exposure scenarios were identified with potential for incidental contact. Nanoparticles of silica or silica and/or alumina agglomerates (or aggregates) were identified in surface samples from work areas where engineered nanoparticles were used or handled. Conclusions: Additional data are needed to evaluate occupational exposures from skin contact with engineered nanoparticles; precautionary measures should be used to minimize potential cutaneous exposures in the workplace.
LYMPHOMATOID PAPULOSIS AND PITYRIASIS LICHENOIDES: ARE THEY RELATED* *

Ever since Macaulay (1968) first introduced the term lymphomatoid papulosis there has been continued speculation as to its nosological identity. Even today there is still no absolute consensus—this in itself suggests that possibly a number of different diseases may simulate both the clinical and histological changes seen in lymphomatoid papulosis. The purpose of this article is to look at the spectrum of lymphomatoid papulosis and suggest a definition and subdivision which may help clinicians dealing with these rarer problem cases. In doing this the author cannot consider himself to be an 'innocent bystander' since, as will be seen shortly, he is firmly committed to the view that, at least in part, lymphomatoid papulosis is closely related to pityriasis lichenoides. Broadly there have been three opinions concerning the nosology of lymphomatoid papulosis: (1) Lymphomatoid papulosis as a variant of pityriasis lichenoides (Verallo & Haserick, 1966; Pinol Aguade, Rubio & Grimalt, 1967; Couperus, 1967; Muller & Schulze, 1971; MacMillan & Vickers, 1971; Black & Wilson Jones, 1972; Valentino & Helwig, 1973). (2) Lymphomatoid papulosis as a lymphoreticular neoplasm: lymphomatoid papulosis eventuating as a malignant lymphoma (Samman, 1964); histiomonocytic reticulosis (Dupont, 1965); skin reticulosis (Takada, 1968)5 malignant reticulosis (Kawada et al., 1969); mycosis fungoides (Fine, Meltzer & Rudner, 1974; Lutzner et ah, 1975; Brehmer-Anderson, 1976; Thomsen & Schmidt, 1977); Hodgkin's disease (one case), lymphocytic lymphoma (one case) (Sheen, Doyle & Winkelmann, 1981); Hodgkin's disease (Dowd, Munro & Stansfeld, 1981); systemic lymphoma (Messenger, Marshall & Summerly, 1981). (3) Lymphomatoid papulosis as a distinctive disease by clinical, histological and biological criteria which may be differentiated histologically from pityriasis lichenoides and mycosis fungoides in nearly every instance (Weinman & Ackerman, 1981; Haserick, 1981).
Osteoblasts promote migration and invasion of myeloma cells through upregulation of matrix metalloproteinases, urokinase plasminogen activator, hepatocyte growth factor and activation of p38 MAPK

Formation of osteolytic lesions is a key pathophysiological feature in multiple myeloma and results from the interaction of myeloma cells with the bone marrow microenvironment. Matrix metalloproteinases (MMPs) and plasmin may be involved in bone destruction, but their precise roles have not been clarified. Furthermore, the impact of osteoblast‐related alterations on myeloma bone disease is not well understood. We addressed this complex phenomenon by applying a coculture system between myeloma cells and osteoblasts. Osteoblasts induced expression of MMP‐1 and upregulated the expression of MMP‐2, urokinase plasminogen activator (uPA) and hepatocyte growth factor (HGF) in myeloma cells. In turn, interaction with myeloma cells led to abundant MMP‐1 expression in osteoblasts. Because MMP‐1 degrades collagen, its upregulation might represent an essential mechanism contributing to bone destruction. Cocultures using primary myeloma cells confirmed the results obtained with cell lines. The mechanisms responsible for MMP‐1 upregulation are mediated by both membrane‐bound and soluble factors, and involve the p38 mitogen‐activated protein kinase (MAPK) pathway. The interaction with osteoblasts enhances the capability of myeloma cells to transmigrate and invade through Matrigel or type I collagen. Using appropriate inhibitors, we provide evidence that these processes involve MMPs, uPA, HGF and activation of p38 MAPK.
Influence of common and rare genetic variation on warfarin dose among African-Americans and European-Americans using the exome array.

AIM We conducted a genome-wide association study using the Illumina Exome Array to identify coding SNPs that may explain additional warfarin dose variability. PATIENTS & METHODS Analysis was performed after adjustment for clinical variables and genetic factors known to influence warfarin dose among 1680 warfarin users (838 European-Americans and 842 African-Americans). Replication was performed in an independent sample. RESULTS We confirmed the influence of known genetic variants on warfarin dose variability. Our study is the first to show the association between rs12772169 and warfarin dose in African-Americans. In addition, genes COX15 and FGF5 showed significant association in European-Americans. CONCLUSION We identified some novel genes/SNPs that underpin warfarin dose response. Further replication is needed to confirm our findings.
Osteonecrosis in patients with systemic lupus erythematosus develops very early after starting high dose corticosteroid treatment

OBJECTIVES To investigate the actual time of onset of osteonecrosis (ON) after high dose corticosteroid treatment in systemic lupus erythematosus (SLE). METHODS 72 patients with active SLE, who received high dose corticosteroid for the first time, for the development of ON at hips and knees were monitored by magnetic resonance imaging for at least 12 months. RESULTS ON lesions were detected in 32/72 patients (44%) between one and five months (3.1 months on average) after starting high dose corticosteroid treatment. No osteonecrotic lesion was newly detected from the sixth month of treatment until the end of the follow up period. CONCLUSION The findings suggested that the actual time of onset of ON in SLE is within the first month of high dose corticosteroid treatment.
Determinants of Smallholder Farm Households’ Adaptation Responses to Climate Change Induced Rice Insufficiency at Household Level in Sumedang District, Indonesia

The global concerns on climate change adaptation has now shifted from a high-level advocacy on “the need to adapt” to a regional or local level responses on “how to adapt”. Keeping in mind the locally specific impact of climate change on agriculture and hence the smallholders’ food insecurity, effective adaptation measures cannot be manifested, unless the stakeholders managed to master the locally specific context of the impacted system. This study provides an analysis on factors determining the diversity of the smallholder farm households’ current adaptation responses to climate change induced household-level rice insufficiency, based on which recommendation could be formulated as to shifting individual household’s existing adaptation response to the current best adaptation practice identified empirically in the study area. The result suggested that rice yield reduction impact of climate change affected the smallholder household’s rice sufficiency level (HRSL) to the extent variable across different types of individual household’s existing autonomous adaptation responses. Among the four general types of adaptations identified, the combined on- and off-farm adapted group generated the highest HRSL, followed consequently by the off-farm and on-farm adapted group. Under baseline, the average HRSL of the three types of adaptations are recorded at 61.64%, 58.40%, and 56.12%, respectively, higher than that of the non-adapted which is 54.53%. In terms of resilience to future climate, the result of the study indicated that the combined on- and off-farm adapted households have been the most resilient group, as indicated by its lowest HRSL reduction, both to the near and far-future projection. While the off-farm adapted generated higher HRSL, the on-farm adapted group indicated better resilience to changing climate than the off-farm adapted. Similar pattern in climate change-induced rice yield and its implication on HRSL was shared between RCP4.5 and RCP8.5 for both near- and far-future projections. The result of adaptation determinants analysis suggested that climate change adaptation-strengthening intervention to the study area should be better targetted to female-, older-age-, and lower-educated headed households. Moreover, the interventions should focus more on activities that expose these households to climate change-related innovation and technology on the one side, and improve the household’s access to credit, and hence financial resources, on the other side, through which the smallholder households gain sufficient capacity to adopt the empirically identified existing best adaptation practice.
Leadership Skills Of College Of Agriculture Graduates

Leadership development has been identified as one of the objectives of undergraduate agriculture degree programs in land-grant colleges throughout the United States (Love & Yoder, 1989). Efforts to enhance the leadership skills of agriculture students have varied widely across degree programs, departments, and institutions. Leadership development efforts in some institutions have been promoted through courses to enhance leadership attributes of students. Other institutions have adopted a more laissez faire posture by encouraging leadership development through participation in departmental clubs, student organizations, and activities (Schumacher & Swan, 1993).
Embedding Words as Distributions with a Bayesian Skip-gram Model

We introduce a method for embedding words as probability densities in a low-dimensional space. Rather than assuming that a word embedding is fixed across the entire text collection, as in standard word embedding methods, in our Bayesian model we generate it from a word-specific prior density for each occurrence of a given word. Intuitively, for each word, the prior density encodes the distribution of its potential ‘meanings’. These prior densities are conceptually similar to Gaussian embeddings of ėwcitevilnis2014word. Interestingly, unlike the Gaussian embeddings, we can also obtain context-specific densities: they encode uncertainty about the sense of a word given its context and correspond to the approximate posterior distributions within our model. The context-dependent densities have many potential applications: for example, we show that they can be directly used in the lexical substitution task. We describe an effective estimation method based on the variational autoencoding framework. We demonstrate the effectiveness of our embedding technique on a range of standard benchmarks.
A Transcriptomic and Proteomic Characterization of the Arabidopsis Mitochondrial Protein Import Apparatus and Its Response to Mitochondrial Dysfunction1[w]

Mitochondria import hundreds of cytosolically synthesized proteins via the mitochondrial protein import apparatus. Expression analysis in various organs of 19 components of the Arabidopsis mitochondrial protein import apparatus encoded by 31 genes showed that although many were present in small multigene families, often only one member was prominently expressed. This was supported by comparison of real-time reverse transcriptase-polymerase chain reaction and microarray experimental data with expressed sequence tag numbers and massive parallel signature sequence data. Mass spectrometric analysis of purified mitochondria identified 17 import components, their mitochondrial sub-compartment, and verified the presence of TIM8, TIM13, TIM17, TIM23, TIM44, TIM50, and METAXIN proteins for the first time, to our knowledge. Mass spectrometry-detected isoforms correlated with the most abundant gene transcript measured by expression data. Treatment of Arabidopsis cell culture with mitochondrial electron transport chain inhibitors rotenone and antimycin A resulted in a significant increase in transcript levels of import components, with a greater increase observed for the minor isoforms. The increase was observed 12 h after treatment, indicating that it was likely a secondary response. Microarray analysis of rotenone-treated cells indicated the up-regulation of gene sets involved in mitochondrial chaperone activity, protein degradation, respiratory chain assembly, and division. The rate of protein import into isolated mitochondria from rotenone-treated cells was halved, even though rotenone had no direct effect on protein import when added to mitochondria isolated from untreated cells. These findings suggest that transcription of import component genes is induced when mitochondrial function is limited and that minor gene isoforms display a greater response than the predominant isoforms.