Miracle-dz/UniFAR-FTUs huggingface dataset:
Delivery Efficiency of miR-21i-CPP-SWCNT and Its Inhibitory Effect on Fibrosis of the Renal Mesangial Cells

MicroRNA 21 miR-21 was proved to cause renal fibrosis and the inhibition of miR-21 would improve the poor prognosis in renal cell carcinoma diseases. The complementary oligonucleotide of mature miR-21 was considered to be an effective intracellular miR-21 inhibitor miR-21i. The directly effective delivery of miR-21i into fibrotic cell is a facile method for treatment of renal fibrosis. Herein, the miR-21i-CPP-SWCNT delivery system, synthesized via single-walled carbon nanotube SWCNT and cell-penetrating peptide CPP, was taken as a novel fibrosis-targeting therapeutic carrier. The miR-21i and CPP firstly bind together via electrostatic forces, and subsequently miR-21i-CPP binds to the surface of SWCNTs via hydrophobic forces. CPP could endow the delivery system with targeting property, while SWCNT would enhance its penetrating ability. The exogenous miR-21i released from the designed miR-21i-CPP-SWCNTs had successfully inhibited the expression of fibrosis-related proteins in renal mesangial cells RMCs. We found that the expression of TGF-β1 proteins was more sensitive to miR-21i-CPP-SWCNT than the expression of α-SMA proteins.
On the analytic approximation of bulk collision rates of non-spherical hydrometeors

Abstract. Analytic approximations of the binary collision rates of hydrometeors are derived for use in bulk microphysical parameterizations. Special attention is given to non-spherical hydrometeors like raindrops and snowflakes. The terminal fall velocity of these particles cannot be sufficiently well approximated by power-law relations which are used in most microphysical parameterizations, and therefore an improved formulation is needed. The analytic approximations of the bulk collision rates given in this paper are an alternative to look-up tables and can replace the Wisner approximation, which is used in many atmospheric models.
Rediscovery of Cameroon Dolphin, the Gulf of Guinea Population of Sousa teuszii (Kükenthal, 1892)

Since the 1892 discovery of the Atlantic humpback dolphin Sousa teuszii (Delphinidae), a species endemic to coastal western Africa, from a skull collected in Cameroon, not a single record has been documented from the country or neighbouring countries. Increasing concern about the continued existence of the Gulf of Guinea population of S. teuszii or “Cameroon dolphin” prompted an exploratory survey in May 2011. Shore-based effort, on foot (30.52 km; 784 min), yielded no observations. Small boat-based surveys (259.1 km; 1008 min) resulted in a single documented sighting of ca. 10 (8–12) Cameroon dolphins in shallow water off an open sandy shore near Bouandjo in Cameroon's South Region. The combination of a low encounter rate of 3.86 individuals (100 km)−1 suggesting low abundance and evidence of both fisheries-caused mortality and of habitat encroachment raises concerns about the Cameroon dolphin's long-term conservation prospect. Our results add to indications concerning several other S. teuszii populations that the IUCN status designation of the species as “Vulnerable” may understate its threat level.
The Dummy DE in Chinese Resultatives

This paper will concentrate on syntactic arguments for the existence of ExtP, and not discuss its function. As to the function of ExtP, let me just point out the following. First, the basic structure for result sentences in Chinese which I will argue for here is given in (4) below. The ExtP is a complement to the matrix verb in essentially the same way as Hoekstra (1988, 1990) argues that the result denoting small clause (SC) in sentences like The joggers ran [the pavement thin] is the complement to the matrix verb: it telecizes the a-telic, inherently dynamic matrix predicate by specifying the state which terminates this event. Phrased
Effect of health education on breastfeeding initiation techniques among postnatal mothers admitted in a tertiary care centre of Raipur city, Chhattisgarh

Background: The health benefits of breastfeeding are well documented in public health and medical literature worldwide. It is reported in various studies that early lactation supported by correction of positioning and attachment of breastfeeding improves the rate of effective suckling. However, related to breastfeeding technique, no studies were conducted in Chhattisgarh, Therefore, this study was undertaken to assess the improvement in breastfeeding technique (positioning & attachment) after intervention(health education and support) among mother-early neonate units admitted in postnatal ward immediately after delivery in a tertiary level health institute.Methods: A Quasi-experimental (Single group pre and post design) carried out in hospital settings from August to September 2014. This study involved 414 both preterm and term babies who were born during the study period at Dr. BRAM hospital, Raipur with their mothers.Mothers were observed for breast feeding technique on first day followed by correction and post interventional observation.Results: After intervention statistically significant improvement was seen in overall body positioning status and attachment during breast feeding 43.3%, 42.1% respectively.Conclusions: Present study indicate that educating and supporting the mothers regarding correct breastfeeding technique is important to help them in the stage when they are establishing breastfeeding. This also avoids early and late problems related to breastfeeding.
Microalbuminuria in Patients with Diabetes Mellitus: Prevalence and Associated Risk factors Title of your

Microalbuminuria is the most leading cause for cardiovascular disease, diabetic nephropathy, end stage renal diseases, and death among diabetic patients. The study carried out to find out the prevalence of microalbuminuria in a sample of Sulaimani diabetics and to determine its relation to different associated risk factors. The first part of study was a cross-sectional study conducted through examination of records of diabetic patients registered in Sulaimani Diabetic Center from June 2010 to May 2012. The second part was a case- control study that conducted in the same center, including 50 cases of diabetics with positive microalbuminuria, and 50 controls with negative one, that were registered in the same center and matched by age and gender. A specially designed questionnaire was used by researcher to collect information from the records. SPSS version 21.0 was used for data analysis. Males accounts for half of cases and controls, highest proportion of sample was found among age group (60-69) years about 34%. The prevalence of microalbuminuria was 29%. The study showed a statistical significant association of microalbuminuria with obesity, smoking, hypertension, retinopathy, ischemic heart disease, poor glycemic control, and dyslipidemia. In conclusion moderate prevalence of microalbuminuria was found among diabetic patients, the prevalence was more common in poor glycemic control, and hypertensive diabetics. There was significant relation between microalbuminuria and diabetic nephropathy.
Nitrogen mineralization and vegetation along skidding tracks

Une gestion forestiere durable necessite un systeme de desserte forestiere dense par des chemins et des lignes de debardage. La circulation d'engins forestiers lourds cause des degâts parfois importants au sol et aux peuplements forestiers. Une hetraie calcicole ainsi qu'une hetraie et une pessiere sur des stations acidiclines ont fait l'objet de la presente etude dont l'objectif est l'appreciation des consequences de la circulation sur la mineralisation d'azote ainsi que sur la vegetation. Par rapport a des peuplements voisins non perturbes, la mineralisation d'azote nette dans les ornieres est sensiblement ralentie. Malgre ce fait, de nombreuses especes des ourlets et des milieux ouverts (especes ruderales), presentant un besoin eleve d'azote, apparaissent le long des lignes de debardage. Les peuplements fermes sont caracterises par des especes forestieres typiques. Ainsi, on constate une plus grande diversite d'especes le long des lignes de debardage.
Prior Self-Efficacy Interacts with Experiential Valence to Influence Self-Efficacy among Engineering Students: An Experimental Study.

Background:Self-efficacy toward science learning has been shown to play a crucial role in determining students’ motivation and achievements. Social cognitive theory proposes that positive and negative task outcomes affect mastery experiences from which self-efficacy develops. The current research examined whether prior level of self-efficacy would serve as a moderator of the effect of experiential valence on self-efficacy in science learning.Materials and methods:One hundred and thirty engineering undergraduates with varying levels of prior self-efficacy (high, medium, and low) were randomly assigned to receive either a positive or a negative task experience regarding circuit design.Results:The findings of our experment showed that students with lower levels of self-efficacy appeared to be more affected by positive versus negative task experiences, and those with higher levels of self-efficacy tended to be more affected by negative versus positive task experiences.Conclusions:The present findings indicate that both valence of task experience and students’ prior self-efficacy affect their changes in self-efficacy with regard to STEM learning. The present findings have far-reaching implications for enhancing self-efficacy on learning of science.
Evaluating Effectiveness of Rangeland Management Cooperatives in Gonbad, Iran

There is a different function between rangeland management cooperatives in which effectiveness is also affected. The aim of this research was to identify and analyze the effectiveness of rangeland management cooperatives in Gonbad, Iran in 2015. The research was performed using a descriptive statistical method. The statistical populations include all the members of rangeland management cooperative in Gonbad. The sample size was determined by Cochran (n=200). For sampling, the random cluster method was used. The questioner was provided with 40 variables. Validity and reliability of questionnaire were confirmed according to the experts of Department of Natural Resources and Watershed Management, Golestan province and Cronbach's alpha was given as 0.97. Factor analysis was conducted based on principal components and varimax rotation for recognizing the function of cooperatives of rangeland management using SPSS software. Factor analysis considers 40 variables for five manageable and understandable factors. Five extracted factors were information and extension services, technical support services, collaboration and social interaction, rangeland rehabilitation and supply of inputs accounted for 74% of total variation for range management cooperatives. Therefore, it is important for successful cooperatives to pay attention to these five factors.
Atomic Ensemble Effects and Non-Covalent Interactions at the Electrode–Electrolyte Interface

Cyanide-modified Pt(111) electrodes have been recently employed to study atomic ensemble effects in electrocatalysis. This work, which will be briefly reviewed, reveals that the smallest site required for methanol dehydrogenation and formic acid dehydration is composed of three contiguous Pt atoms. By blocking these trigonal sites, the specific adsorption of anions, such as sulfate and phosphate, can be inhibited, thus increasing the rate of oxygen reduction reaction by one order of magnitude or more. Moreover, alkali metal cations affect hydrogen adsorption on cyanide-modified Pt(111). This effect is attributed to the non-covalent interactions at the electrical double layer between specifically adsorbed anions or dipoles and the alkali metal cations. A systematic investigation is conducted on the effect of the concentration of alkali metal cations. Accordingly, a simple model that reproduces the experimental observations accurately and enables the understanding of the trends in the strength of the interaction between M + and CN ad when moving from Li + to Cs + , as well as the deviations from the expected trends, is developed. This simple model can also explain the occurrence of super-Nernstian shifts of the equilibrium potential of interfacial proton-coupled electron transfers. Therefore, the model can be generally applied to explain quantitatively the effect of cations on the properties of the electrical double layer. The recently reported effects of alkali metal cations on several electrocatalytic reactions must be mediated by the interaction between these cations and chemisorbed species. As these interactions seem to be adequately and quantitatively described by our model, we expect the model to also be useful to describe, explain, and potentially exploit these effects.
Predictive Value of a Lake Sturgeon Habitat Suitability Model

Abstract Although many fish habitat suitability models (HSMs) have been developed and used in wildlife management and conservation planning, comparatively few have been independently validated. Given the importance of such models in habitat management and conservation policy, the extent to which they accurately predict population parameters (e.g., abundance or recruitment) is a critical issue. Here we apply an HSM recently developed for lake sturgeon Acipenser fulvescens in northern rivers to three reaches of the Ottawa River, using measurements of the model's key variables (substrate type, water depth, and velocity) to generate spatially explicit predictions of habitat suitability. We then test the predictive power of the model by comparing lake sturgeon catch per unit effort (CUE) when using short-set gill nets in areas predicted to have good (habitat suitability index values >0.6) and poor (values < 0.3) adult and juvenile foraging habitats. Consistent with model predictions, significantly more lake st.
Variability in Volcanic Glass Preparation Methods: Qualitative Analysis of Apparent Porosity between Pumiceous and Non-Pumiceous Glass Shards

Stable isotopes from ancient water have been used extensively to reconstruct paleoclimates and paleoenvironments (e.g. Bershaw et al., 2010, Cyr et al., 2005, Fan et al., 2017, Quade et al., 2011, Rowley and Garzione, 2007). Volcanic glass found in ash tuffs have been shown to preserve hydrogen (H) isotopes from meteoric water at the time of deposition (Cassel and Breecker, 2017) making it a useful paleowater proxy (e.g. Canavan et al., 2014, Cassel et al., B2009, Friedman et al., 2013, Saylor and Horton, 2014). Carlson (2018) showed differences in δD between two different preparation methods in volcanic glass analysis and suggests that strict grain size filtering and hydrofluoric acid (HF) treatment produce the most reliable results, similar to Cassel and Breecker (2017) findings. Samples were deemed reliable if they contained >99% glass without bubbles. Glass shards with bubbles are less dense and described as pumiceous. Though preparation methods recommend removing pumiceous shards, it is not clear how they affect isotopic results, if at all. I investigate this by comparing pumiceous textures, water concentration, and δD values of different glass samples. Based on the results of this pilot I conclude that; 1) δD and wt. % water are not affected by apparent porosity, 2) The Cassel and Breecker (2017) method effectively removes hydrogen contamination, even in previously discarded pumiceous samples where corrosion is extensive, suggesting pumiceous glass shards can also be used for paleoenvironmental reconstruction. Future work should confirm these results with a more extensive dataset.
Gatelite-(Ce), a new REE-bearing mineral from Trimouns, French Pyrenees: Crystal structure and polysomatic relationships with epidote and törnebohmite-(Ce)

Abstract Gatelite-(Ce), ideally (Ca1REE3)Σ=4[Al2(Al,Mg)(Mg,Fe,Al)]Σ=4[Si2O7][SiO4]3(O,F) (OH,O)2, is a newly identified mineral from the Trimouns talc deposit, Luzenac, Ariège, French Pyrenees. The mineral occurs as striated colorless crystals finely intergrown with minute lamellae of törnebohmite- (Ce). Associated minerals include pyrite, aeschynite-(Y), dolomite, törnebohmite-(Ce), dissakisite- (Ce), talc, and quartz. Gatelite-(Ce) is insoluble in HCl, relatively hard (Mohs hardness 6-7), brittle with irregular fracture, and exhibits good {100} and imperfect {001} cleavages. Gatelite-(Ce) is monoclinic, space group P21/a, with the following unit-cell parameters: a = 17.770(4), b = 5.651(1), c =17.458(4) Å, b =116.18(2)°, V = 1573.3(6) Å3, and Z = 4. The strongest five powder-diffraction lines [d in Å (I/Io) (hkl)] are 15.67 (87) (001); 3.49 (50) (4̅12); 2.97 (100) (2̅15); 2.83 (44) (020); and 2.61 (56) (6̅12). Electron-microprobe analysis supported by single-crystal structure determination yielded the following empirical formula: (Ca1.09La0.54Ce1.36Pr0.14Nd0.75Sm0.11Dy0.01Y0.04)Σ4. 04 (Al3.06Mg0.51 Fe2+0.32Nb0.01)Σ3. 90 Si5.06 O20.26 (OH)1.60 F0.14. The calculated density (from the empirical formula) is 4.51 g/ cm3. The structure was solved by direct methods and refined to Robs = 4.65%. It consists of edgesharing octahedral chains running along the b axis, cross-linked by SiO4 and Si2O7 groups. The remaining large cavities are occupied by Ca and REE. The structure of gatelite-(Ce) can be easily described as a regular alternance of slabs of epidote-type structure (E) and slabs of törnebohmitetype structure (T) parallel to the (001) plane. Gatelite-(Ce) can be regarded as a ET polisome within a polysomatic series having epidote and törnebohmite as end-members.
Spatiotemporal Variations of Extreme Precipitation under a Changing Climate in the Three Gorges Reservoir Area (TGRA)

The Three Gorges Dam (TGD) is one of the largest hydroelectric projects in the world. Monitoring the spatiotemporal distribution of extreme precipitation offers valuable information for adaptation and mitigation strategies and reservoir management schemes. This study examined variations in extreme precipitation over the Three Gorges Reservoir area (TGRA) in China to investigate the potential role of climate warming and Three Gorges Reservoir (TGR). The trends in extreme precipitation over the TGRA were investigated using the iterative-based Mann–Kendall (MK) test and Sen’s slope estimator, based on weather station daily data series and TRMM (Tropical Rainfall Measuring Mission) data series. The mean and density distribution of extreme precipitation indices between pre-dam and post-dam, pre-1985 and post-1985, and near and distant reservoir area were assessed by the Mann–Whitney test and the Kolmogorov–Smirnov test. The ratio of extreme precipitation to non-extreme precipitation became larger. The precipitation was characterized by increases in heavy precipitation as well as decreases in light and moderate rain. Comparing extreme precipitation indices between pre-1985 (cooling) and post-1985 (warming) indicated extreme precipitation has changed to become heavier. Under climate warming, the precipitation amount corresponding to more than the 95th percentile increased at the rate of 6.48%/°C. Results from comparing extreme precipitation for the pre- and post-dam, near reservoir area (NRA) and away from the reservoir area (ARA) imply an insignificant role of the TGR on rainfall extremes over the TGRA. Moreover, the impoundment of TGR did not exert detectable impacts on the surface relative humidity (RH) and water vapor pressure (WP).
Measuring the preference for dwelling characteristics of Melbourne : railway stations and house prices

The relationship between public transportation and home values has proven to be complex, with studies providing divergent findings. Using Victorian Valuer General Data for 2009, this paper applies a hedonic pricing approach to the Melbourne metropolitan housing market in order to estimate the impacts of proximity to a train station on residential property prices. The findings reveal that, proximity to train stations has an overall positive effect on property values. In general, all other things being equal, being located 1 km further out from a train station is associated with a 2% discount in sale price. The magnitude of this relationship is most clearly stable up to 5 kms from a train station. No dis-amenity effect on sale price for properties in close proximity to a train station was found.
Resonant load control methods for industrial servo drives

High-performance servo drives are often limited by mechanical load resonance. In this paper, seven methods of resonant-load control are compared for their ability to improve performance in the presence of a low-frequency (100 Hz) lightly damped resonance. The seven methods are: notch filter, bi-quad filter, rigid body observers, low-pass filter, observer filtering, active resonance damping and center-of-mass control. Several of the methods are based on filtering the command signal; the remaining methods are based on signals acquired from an observer. Development of these methods is presented; each method is applied to a physical system and evaluated for effects on command response and dynamic stiffness.
Osteosarcoma: From Molecular Biology to Mesenchymal Stem Cells

Osteosarcoma is the most common primary malignant tumour of bone. Currently, despite treatment with multi-agent chemotherapy and limb salvage surgery, the five-year survival rate for osteosarcoma remains at 70%. The pathogenesis of osteosarcoma is complex and involves alterations in cellular apoptosis, adhesion, migration, invasion and molecular signalling. Research most recently has focused on the molecular basis of the disease with the goal of identifying novel therapeutic targets. To this end, mesenchymal stem cells (MSCs) have been identified to play a role in sarcomagenesis. MSC transfor - mation may give rise to tumours, whereas interactions of MSCs with osteosarcoma cells in the tumour microenvironment may cause increased cell proliferation. This is in stark contrast to the role of MSCs as a promising source for tissue repair and regeneration. In order to utilize MSCs for biological reconstruction in the setting of osteosarcoma, further research is necessary to delineate the role of MSCs in osteosarcoma transformation and progression. Further studies defining the role of MSCs in osteosarcoma pathogenesis are required prior to studies of therapeutic safety and efficacy.
Feeling Controlled and Drinking Motives Among College Students: Contingent Self-Esteem as a Mediator

This article presents an examination of college student drinking motives from a self-determination perspective. We predicted positive associations between controlled orientation (a chronic orientation toward pressures and experiencing a lack of choice in one's behaviors), and drinking as a means of regulating affect (enhancement and coping motives) and social approval (social rewards and conformity motives). Contingent self-esteem involves deriving self-worth from meeting expectations and was expected to mediate the relation between controlled orientation and drinking motives, which were in turn expected to predict alcohol consumption and related consequences. College students' (N = 204) controlled orientation, contingent self-esteem, motives for drinking, and patterns of alcohol use were assessed. Mediation analyses provided support for our theoretical framework. Results suggest that “controlled” individuals drink to regulate affect and social approval in part because they have a greater tendency to base self-worth on contingencies.