Miracle-dz/UniFAR-FTUs huggingface dataset:
Dynamic Models of Planar Sliding

In this paper, we present a principled method to model gen- eral planar sliding motion with distributed convex contact patch. The effect of contact patch with indeterminate pressure distribution can be equivalently modeled as the contact wrench at one point contact. We call this point equivalent contact point. Our dynamic model embeds ECP within the equations of slider's motion and friction model which approx- imates the distributed contact patch, and eventually brings us a system of quadratic equations. This discrete-time dynamic model allows us to solve for the two components of tangential friction impulses, the friction moment and the slip speed. The state of the slider as well as the ECP can be computed by solving a system of linear equations once the contact impulses are computed. In addition, we derive the closed form solutions for the state of slider for quasi-static motion. Furthermore, in pure trans- lation case, based on the discrete-time model, we present the closed form expressions for the friction impulses the slider suffers and the state of it at each time step. Simulation examples are shown to demonstrate the validity of our approach.
Increased Number and Activity of a Lateral Subpopulation of Hypothalamic Orexin/Hypocretin Neurons Underlies the Expression of an Addicted State in Rats

Background The orexin system is important for reward-driven motivation but has not been implicated in the expression of a multi-phenotype addicted state. Methods Rats were assessed for economic demand for cocaine prior to and following 14d of short- (ShA), long- (LgA) or intermittent-access (IntA) to cocaine. Rats were also assessed for a number of other DSM- V-relevant addiction criteria following differential access conditions. Orexin system function was assessed by i) quantification of numbers and activity of orexin cells, ii) pharmacological blockade of the orexin-1 receptor, and iii) subregion-specific knockdown of orexin cell populations. Results IntA produced a cluster of addiction-like behaviors that closely recapitulate key diagnostic criteria for addiction to a greater extent than LgA or ShA. IntA was associated with plasticity in orexin cell function, including increased number and activity of orexin-expressing neurons within the lateral hypothalamic (LH) subregion. This plasticity persisted during protracted withdrawal from cocaine for at least 6 months and was associated with enhanced incubation of craving. Selective knockdown of LH orexin neurons reversed the addicted state, and orexin-1 receptor signaling played a larger role in drug seeking after IntA. Conclusions These data provide the first evidence that LH orexin system function extends beyond general reward seeking to play a critical role in the expression of a multi-phenotype addicted-like state. Thus, the orexin/hypocretin system is a potential novel target for pharmacotherapies designed to treat cocaine addiction. In addition, these data point to the IntA model as a preferred approach to modeling addictionlike behavior in rats.
Effectiveness of additional resection of the invasive cancer-positive proximal bile duct margin in cases of hilar cholangiocarcinoma.

Background The survival benefits of additional resection of the positive proximal ductal margin (PM) in hilar cholangiocarcinoma (HCCA) remains controversial. This retrospective study investigated the effectiveness of additional resection of the invasive cancer PM under different levels of preoperative carbohydrate antigen 19-9 (CA19-9). Methods Patients who underwent hepatectomy for HCCA from 2000 to 2017 were analyzed. Surgical variables, resection margin status, length of the PM (LPM), prognostic factors, and survival were evaluated. Results A total of 228 patients were enrolled: 175 PM(-) without additional resection patients (group A), 21 PM(-) after additional resection (group B), 16 PM(+) without additional resection (group C), and 16 PM(+) after additional resection (group D). The median survival of group B (20.99 months) was similar to that of group A (23.00 months; P=0.16), and both were significantly better than those of group C (11.60 months) and D (9.50 months), especially when preoperative CA19-9>150 U/mL (P<0.05). The survival of patients with an LPM >10 mm was significantly better compared with those with an LPM ≤10 mm, especially when preoperative CA19-9 was >150 U/mL (P<0.05). Only in the LPM >10 mm group, the survival of group B was comparable with that of group A (P>0.05). Conclusions HCCA patients could get a survival benefit from a negative PM resulting from additional resection. Survival could be comparable with that of negative PM without additional resection among HCCA patients. An LPM >10 mm is possibly more associated with better survival compared with whether additional resection of the positive PM is performed under different levels of preoperative CA19-9.
Effect of Early Metoprolol During ST-Segment Elevation Myocardial Infarction on Left Ventricular Strain: Feature-Tracking Cardiovascular Magnetic Resonance Substudy From the METOCARD-CNIC trial. JACC: Cardiovascular Imaging (7), 1188-1198.

Objectives: To evaluate the effect of early intravenous metoprolol on left ventricular (LV) strain assessed with feature tracking cardiovascular magnetic resonance (CMR). Background: Early intravenous metoprolol before primary percutaneous coronary intervention (PCI) in ST-segment elevation myocardial infarction (STEMI) portends better outcomes in the METOCARD-CNIC trial. Methods: A total of 197 patients with acute anterior STEMI who were enrolled in the METOCARD-CNIC trial (100 allocated to intravenous metoprolol before primary PCI and 97 controls) were evaluated. LV global circumferential strain (GCS) and global longitudinal strain (GLS) were measured with feature tracking CMR at 1 week and 6 months after STEMI and compared between randomization groups. Results: Patients who received early intravenous metoprolol had significantly more preserved LV strain compared to the controls at 1 week after STEMI (GCS: -13.9±3.8% versus -12.6±3.9%, respectively; P =0.013; GLS: -11.9±2.8% versus -10.9±3.2%, respectively; P =0.032). In both groups, LV strain significantly improved during follow-up (mean difference between 6-month and 1-week strain for the metoprolol group: GCS: -2.9%, 95% CI: -3.5% to -2.4; GLS: -2.9%, 95% CI: -3.4 to -2.4; both P <0.001; the control group: GCS: -3.4%, 95% CI: -3.9% to -2.8%; GLS: -3.4%, 95% CI: -3.9% to -3.0%; both P <0.001). ABSTRACT Feature tracking CMR allows myocardial strain assessment from standard CMR cine images. In 197 patients with acute anterior STEMI (100 randomized to intravenous metoprolol before primary PCI and 97 controls) GCS and GLS were evaluated with feature tracking CMR at 1 week and 6 months after STEMI. Overall, GCS and GLS improved from 1 week to 6 months after STEMI. Early intravenous metoprolol before primary PCI was associated with significantly less patients with severely depressed LV GCS and GLS at both time points, supporting its use in clinically stable STEMI population. Feature tracking CMR represents a complementary tool to evaluate the benefits of cardioprotective therapies. GCS and GLS showed a tendency towards more preserved values in the metoprolol group, but the differences did not reach the level of statistical significance. These results suggest that GCS and GLS are more
Structural and Optical Properties Correlated with the Morphology of Gold Nanoparticles Embedded in Synthetic Sapphire: A Microscopy Study

This work reports on the electron microscopy analysis of the structure and morphology of gold nanoparticles produced by ion implantation as well as their relationship to their optical properties. Metalic nanoparticles by ion implantation are usually spherical and formed beneath the surface of a dielectric matrix. In this experiment, the matrix was sapphire. After high-energy Si ion irradiation, the gold nanoparticles were elongated into prolate spheroids. Since the nanoparticles are embedded in a dielectric matrix, secondary electron imaging in a JEOL JSM-7800F at low voltage did not allow their analysis. This work proposes an analysis using backscattered electron imaging in a field emission scanning electron microscopy at higher voltages (20 kV) to explore the morphology of the embedded nanoparticles. The samples were observed by cross-sectional view as well as a top view of the surface of the sapphire matrix for exploration and recognition of their morphology, dimensions, distribution, and composition. The analysis was extended by means of Rutherford backscattering spectrometry, X-ray diffraction, and optical extinction spectroscopy. The nanoparticles exhibited structural and optical properties correlated directly to the morphology observed by microscopy. The beam interaction with the sample and the used parameters was simulated in the CASINO code, from which the depth of exploration with distinct parameters used in microscopy analysis was estimated.
Breast Cancer in Pregnancy: A Retrospective Cohort Study

Gestational breast cancer (GBC) is the second most commonly occurring malignancy affecting pregnant women. Management is complex due to potential foetal risks in the setting of maternal treatment. We report on the maternal, foetal, short-term neonatal and placental histopathologic findings of a retrospective cohort of pregnant women with either pre-gestational (group 1) or GBC (group 2) from a tertiary-level maternity care centre. Of the 69 women identified over 12 years, there were 47 in group 1 and 22 in group 2. Demographics, stage of breast cancer at diagnosis were similar in the 2 groups. Women with GBC (group 2) were more likely to receive surgery and chemotherapy or surgery alone as compared to those in group 1. No women with GBC received radiation during pregnancy, but 2 received this treatment postpartum. With regard to pregnancy outcomes, induction of labour was more common in women with GBC, as was preterm birth. Most preterm birth in women with GBC was late preterm, iatrogenic in nature to facilitate postpartum treatment. We conclude comparable pregnancy outcomes for women with GBC as compared to those with pregestational breast cancer.
Immunohistochemical Expression of Nanog and Its Relation with Clinicopathologic Characteristics in Breast Ductal Carcinoma

Background: Cancer stem cells (CSCs) are a group of tumor cells with self-renewal property and differentiation potential. CSCs play a crucial role in malignant progression of several types of tumors. However, what is still controversial is the clinicopathological relationship between the Nanog marker and its prognostic value in the patients with breast cancer. The expression of Nanog in the patients with breast cancer and its correlation with clinicopathological prognostic factors was explored in the present study. Methods: A sample of 120 breast cancer tissues was obtained from the patients who referred to Imam Khomeini Hospital in Sari City, Iran during January 2012 and December 2016. The associations between Nanog expression and clinicopathological factors were analyzed based on immunohistochemical analysis. Results: The expression of Nanog was detected in 67 (55.8%) patients with a high expression rate in 24 (36%) cases (staining index ≥3). Moreover, there was a statistically significant relationship between Nanog expression and clinicopathological factors, including tumor grade (p = 0.001), lymph node metastasis (p = 0.01), and the stage of the disease (p = 0.003). Conclusion: Findings of the study indicate that Nanog may act as a biomarker for prognostic prediction in patients with breast cancer.
Mutational analysis of uterine cervical cancer that survived multiple rounds of radiotherapy

Radiotherapy is an essential component of cancer therapy. Despite advances in cancer genomics, the mutation signatures of radioresistant tumors have not yet been fully elucidated. To address this issue, we analyzed a unique set of clinical specimens from a uterine cervical cancer that repeatedly locally recurred after multiple rounds of radiotherapy. Exon sequencing of 409 cancer-related genes in the treatment-naïve tumor and the tumors that recurred after initial and secondary radiotherapy identified (i) activating mutations in PIK3CA and KRAS, and putative inactivating mutations in SMAD4, as trunk mutation signatures that persisted over the clinical course; and (ii) mutations in KMT2A, TET1, and NLRP1 as acquired mutation signatures observed only in recurrent tumors after radiotherapy. Comprehensive mining of published in vitro genomics data pertaining to radiosensitivity revealed that simultaneous mutations in KRAS and SMAD4, which have not been described previously in uterine cervical cancer, are associated with cancer cell radioresistance. The association between this mutation signature and radioresistance was validated by isogenic cell-based experiments. These results provide proof-of-principle for the analytical pipeline employed in this study, which explores clinically relevant mutation signatures for radioresistance, and demonstrate that this approach is worth pursuing with larger cohorts in the future.
Can you elaborate on that? Addressing participants’ need for cognition in computer-tailored health behavior interventions

ABSTRACT Computer-tailored interventions, which deliver health messages adjusted based on characteristics of the message recipient, can effectively improve a range of health behaviours. Typically, the content of the message is tailored to user demographics, health behaviours and social cognitive factors (e.g., intentions, attitudes, self-efficacy, perceived social support) to increase message relevance, and thus the extent to which the message is read, considered and translated into attitude and behaviour change. Some researchers have suggested that the efficacy of computer-tailored interventions may be further enhanced by adapting messages to suit recipients’ need for cognition (NFC) – a personality trait describing how individuals tend to process information. However, the likely impact of doing so, especially when tailored in conjunction with other variables, requires further consideration. It is possible that intervention effects may be reduced in some circumstances due to interactions with other variables (e.g., perceived relevance) that also influence information processing. From a practical point of view, it is also necessary to consider how to optimally operationalise and measure NFC if it is to be a useful tailoring variable. This paper aims to facilitate further research in this area by critically examining these issues based on relevant theories and existing evidence.
A Variational Observation Model of 3D Object for Probabilistic Semantic SLAM

We present a Bayesian object observation model for complete probabilistic semantic SLAM. Recent studies on object detection and feature extraction have become important for scene understanding and 3D mapping. However, 3D shape of the object is too complex to formulate the probabilistic observation model; therefore, performing the Bayesian inference of the object-oriented features as well as their pose is less considered. Besides, when the robot equipped with an RGB mono camera only observes the projected single view of an object, a significant amount of the 3D shape information is abandoned. Due to these limitations, semantic SLAM and viewpoint-independent loop closure using volumetric 3D object shape is challenging. In order to enable the complete formulation of probabilistic semantic SLAM, we approximate the observation model of a 3D object with a tractable distribution. We also estimate the variational likelihood from the 2D image of the object to exploit its observed single view. In order to evaluate the proposed method, we perform pose and feature estimation, and demonstrate that the automatic loop closure works seamlessly without additional loop detector in various environments.
Identification of up‐regulated transcripts during Pleurotus ostreatus primordium stage and characterization of PoALDH1

In order to isolate the differentially expressed genes in the primordium stage of Pleurotus ostreatus, the SSH cDNA library was constructed using the cDNA from dikaryotic mycelium stage as a driver and the cDNA from primordium stage as a tester. There were 423 significantly differently expressed clones among 2055 positive clones after three times of reverse Northern blot differential screening. After the repeated sequences being removed, 46 genes were identified which were putatively involved in cell rescue and defense, energy metabolism, transcription and protein regulation, membrane proteins, and signal transduction; 18 genes encoding hypothetical proteins with unknown function; 5 genes without any homology. PoALDH1 and its full‐length cDNA sequence were cloned using the Aldehyde dehydrogenase EST isolated from the library. The amino acid sequence of PoALDH1 contains conservative glutamic acid and cysteine residues active sites of aldehyde dehydrogenase family. When exposed to different concentrations of sodium chloride, the mycelium growth was inhibited and the expression level of PoALDH1 was significantly higher than that of the control one, which indicated that PoALDH1 may have the ability to relieve salt stress. The results of this study will provide useful information for isolating growth and development related genes of P. ostreatus.
La convivencia escolar, un reto en la sociedad actual (Revisión)

espanolEl presente trabajo expone consideraciones teorico-practicas acerca del rol de la convivencia escolar en la escuela cubana actual; asi como la necesidad de la orientacion educativa que deben desarrollar los docentes en la secundaria basica con las familias y los estudiantes para lograr alcanzar la sociedad cubana a que se aspira. Se describen resultados de encuestas y observaciones a clases y otras actividades en la ESBU “Manuel Ascunce Domenech”, del municipio Las Tunas, de la provincia de igual nombre en la parte oriental de Cuba. EnglishThe present work exposes theoretical-practical considerations about the list of the school coexistence in the current Cuban school; as well as the necessity of the educational orientation that you/they should develop the educational ones in the basic secondary with the families and the student to be able to reach the Cuban society to that it is aspired. Results of surveys and observations are described to classes and other activities in the ESBU "Manuel Ascunce Domenech", of the municipality The Tunas, of the equal county name in the oriental part of Cuba.
Response to Nunes and colleagues letter: The data do not seem to support the effect of stretch training in increasing MT

The letter by JP Nunes and colleagues raise concerns over the conclusions and results of the manuscript "Stretch training induces unequal adaptation in muscle fascicles and thickness of the medial and lateral gastrocnemii" published in Scand J Med Sci Sports 27(12):1597-1604, 2017 based on the statistical analysis employed. Nunes et al., are thanked for the careful consideration of our published work, which has given us the opportunity to provide additional data and statistics to address the published conclusion of increased gastrocnemii muscle thickness (MT) with chronic static stretch training. This article is protected by copyright. All rights reserved.
Violence towards healthcare workers: A study conducted in Abha City, Saudi Arabia

Background: Workplace violence in healthcare settings is a common, but an underreported problem that has been largely ignored. Violence against healthcare workers can have an adverse effect on their performance outcomes and thus influence patients' health and satisfaction. The aim of this study was to determine the frequency and types of violence against healthcare workers in a Saudi Arabian city. It was also to identify the risk factors of violence against healthcare workers and to investigate the possible consequences of such behavior. Materials and Methods: In Abha city, there are two government hospitals and ten primary healthcare centers. All healthcare workers in these healthcare institutions including physicians, nurses, dentists, pharmacists, laboratory technicians or specialists, radiologists, social workers, and psychologists were eligible to participate in this cross-sectional study. Data were collected using a structured self-administered questionnaire. Results: A total of 738 healthcare workers responded (92% response rate). The mean age was 31 ± 7.7 years (range 21–60) and the majority (64.9%) were females and 69.4% were Saudis. More than half (57.5%) had experienced some workplace violence at least once. Verbal assaults and slaps were the most common form of workplace-related violence (58%). Conclusions: Violence against healthcare workers in Abha city is more common, especially against nurses. The reasons need to be explored in order to set and develop policies, regulations and interventions to prevent violence against workers.
Genomic duplication in the 19q13.42 imprinted region identified as a new genetic cause of intrauterine growth restriction

We report findings from a male fetus of 26 weeks' gestational age with severe isolated intrauterine growth restriction (IUGR). Chromosomal microarray analysis (CMA) on amniotic fluid cells revealed a 1.06‐Mb duplication in 19q13.42 inherited from the healthy father. This duplication contains 34 genes including ZNF331, a gene encoding a zinc‐finger protein specifically imprinted (paternally expressed) in the placenta. Study of the ZNF331 promoter by methylation‐specific‐multiplex ligation‐dependent probe amplification showed that the duplicated allele was not methylated in the fetus unlike in the father's genome, suggesting both copies of the ZNF331 gene are expressed in the fetus. The anti‐ZNF331 immunohistochemical analysis confirmed that ZNF331 was expressed at higher levels in renal and placental tissues from this fetus compared to controls. Interestingly, ZNF331 expression levels in the placenta have previously been reported to inversely correlate with fetal growth parameters. The original observation presented in this report showed that duplication of ZNF331 could be a novel genetic cause of isolated IUGR and underlines the usefulness of CMA to investigate the genetic causes of isolated severe IUGR.
ZnO Nanowires-Based Flexible UV Photodetector System for Wearable Dosimetry

This paper presents a flexible ultraviolet (UV) photodetector (PD) system based on zinc oxide (ZnO) nanowires (NWs) for wearable UV dosimetry. High-crystal quality ZnO NWs have been synthesized by chemical vapour transport technique on c-plane sapphire substrates, and thereafter, transferred and aligned at pre-defined locations on a flexible substrate using dielectrophoresis (DEP). The accurate control over DEP parameters permitted the fabrication of large-area (wafer scale) arrays of ZnO NWs-based UV PDs. Resulting PDs showed photocurrent-to-dark current ratios above 103%, fast response times (<1 s), high sensitivity to different UV light intensities, and good stability under several UV/dark irradiation cycles. In addition, above PDs presented a robust response under extreme bending conditions, which is critical for their application in high-performance wearable UV dosimeters.