Miracle-dz/UniFAR-FTUs huggingface dataset:
Slot-Coupled Circularly Polarized Array Antenna With Substrate-Integrated Waveguide Cavity for Parallel-Plate-Mode Suppression

A slot-coupled circularly polarized (CP) patch antenna with parallel-plate-mode (PPM) suppression for phased array systems is presented in this paper. The radiation performances of the CP array antenna with PPM suppression are improved using a substrate-integrated waveguide (SIW) cavity. In order to obtain a high isolation between the feeds of a feeding circuit, the cavity size and locations of the feeds are attentively designed. In addition, the performances of the proposed array antenna are thoroughly investigated. A comparative study between antennas (with and without the SIW cavity) is presented, involving both simulation and measurement. The proposed antenna with the SIW cavity has a 17-dB lower mutual-coupling level compared with the antennas without the SIW cavity; the individual antennas in the array, therefore, present more consistent and reliable characteristics in terms of impedance and radiation performances. The beam scanning performance of an $8 \times 8$ phased CP array system is experimentally validated, and shown to exhibit the expected improvements in terms of gain, cross-polarization level, and axial ratio. The obtained results clearly demonstrate the advantages of the proposed antenna for CP phased array systems.
The Zinc Content of Bile and Pancreatic Juice in Zinc-Deficient Swine 1

Abstract The content of zinc, magnesium, calcium, bilirubin, and bile acids was determined in the hepatic bile of zinc-deficient and control swine. Zinc deficiency was produced by dietary zinc restriction while pair fed zinc supplemented animals served as controls for observations of hepatobiliary functions. Pigs weighing 5 kg were placed in two groups and fed the respective diets for 6 weeks; hair and skin abnormalities as well as decreased weight gain were present in the zinc-deficient group by this time. Hepatic bile and pancreatic juice were obtained from each animal after careful isolation and cannulation of the pancreatic and bile ducts. Animals were studied for a 3-hr period while under constant secretin stimulation and chloralose anesthesia. During this period, there was a progressive decrease in the biliary concentrations of bilirubin, bile acids, and magnesium in the bile of both groups, while zinc and calcium levels were not altered. The zinc concentrations in pancreatic juice were reduced in the zinc-deficient animals. The zinc content of the serum, liver, kidney, and pancreas was also decreased in this group. The calcium and magnesium content of the serum and organs was similar in the two groups with the exception of decreased magnesium in the kidney of the zinc-deficient pigs. Low content of zinc in the liver and serum of the deficient animals was associated with a zinc concentration in the bile comparable to the control group; however, the relative content of zinc in pancreatic secretion and bile was found to be altered in zinc deficiency. In control animals 60% of the zinc is in the pancreatic secretion and 40% in the bile. These percentages are reversed in zinc-deficient animals in which 60% of the zinc is derived from the bile.
Disposition of morphine-6-glucuronide and morphine in healthy volunteers.

The pharmacokinetics and subjective side effects of i.v. morphine sulphate 120 micrograms kg-1 and morphine-6-glucuronide (M6G) 30 micrograms kg-1 were determined in six healthy volunteers, using a placebo-controlled, single-blind randomized crossover design. Five of these volunteers underwent an additional (non-randomized) study of M6G 60 micrograms kg-1. Subjective side effects were similar following both drugs, but of shorter duration following M6G. Morphine was not detected after administration of M6G. For M6G 30 micrograms kg-1 the mean (SD) volume of distribution, elimination half-life and clearance were 29.38 (18.36) litre, 2.05 (1.2) h and 187.81 (37.41) litre h-1, respectively. These values were not significantly different from those obtained for M6G 60 micrograms kg-1. In all subjects the volumes of distribution and clearances were significantly smaller for M6G than for morphine, but the elimination half-lives were similar.
Change-Point Estimation in Long Memory Nonparametric Models with Applications

We consider the estimation of a change point or discontinuity in a regression function for random design model with long memory errors. We provide several change-point estimators and investigate the consistency of the estimators. Using the fractional ARIMA process as an example of long memory process, we report a small Monte Carlo experiment to compare the performance of the estimators in finite samples. We finish by applying the method to a climatological data example.
Targeting of MyD88 Homodimerization by Novel Synthetic Inhibitor TJ-M2010-5 in Preventing Colitis-Associated Colorectal Cancer.

BACKGROUND The TLR/MyD88 signaling pathway is an important driver of inflammation and cancer and is a possible target for antitumor therapy. METHODS We generated a MyD88 inhibitor (TJ-M2010-5), which was designed to bind to the TIR domain of MyD88 to interfere with its homodimerization, and the TLR/MyD88 signal pathway. We utilized a mouse model of azoxymethane/dextran sodium sulfate (AOM/DSS)-induced colitis-associated cancer (CAC) in combination with TJ-M2010-5 administration to investigate the anti-inflammation-related cancer effect of MyD88 inhibitor in vivo. Data were analyzed with one-way and repeated measures analysis of variance. Differences in survival between groups were compared using the log rank test. All statistical tests were two-sided. RESULTS TJ-M2010-5 inhibited MyD88 homodimerization in transfected HEK293 cells in a concentration-dependent manner and suppressed MyD88 signaling in LPS-responsive RAW 264.7 cells in vitro. In a 10-week CAC mouse model (n = 30 per group), TJ-M2010-5 treatment statistically significantly reduced AOM/DSS-induced colitis and completely prevented CAC development with less related body mass loss, resulted in 0% mortality of treated mice (compared with 53% mortality of control mice), decreased cell proliferation, and increased apoptosis in colon tissue. TJ-M2010-5 treatment also inhibited production of inflammatory cytokines and chemokines (TNF-α, IL-6,G-CSF, MIP-1β, TGF-β1, IL-11, IL-17A, IL-22 and IL-23) and infiltration of immune cells (macrophages, dendritic cells, neutropihls and CD(+)4 T cells) in colon tissues of mice. CONCLUSIONS Our findings suggest that TLR/MyD88 signaling may be a therapeutic target for CAC intervention and MyD88 inhibitors may be a promising therapeutic modality for treating patients with colitis or CAC.
Missed injuries in the era of the trauma scan.

BACKGROUND A rapid computed tomography technique or "trauma scan" (TS) provides high-resolution studies of the head, cervical spine, chest, abdomen, and pelvis. We sought to determine whether TS has decreased missed injuries. A previous study of TS found a 3% missed rate. METHODS After institutional review board approval, trauma patients from January 2001 through December 2008 were reviewed for delayed diagnosis (DD) of injury to the head, cervical spine, chest, abdomen, or pelvis. Missed extremity injuries were excluded. Injury Severity Score, length of stay, type of injury, outcomes, and days to detection were captured. RESULTS Of 26,264 patients reviewed, 90 patients had DD, with an incidence of 0.34%. DD most commonly presented on day 2. Injuries included 16 bowel/mesentery, 12 spine, 11 pelvic, 8 spleen, 6 diaphragm, 5 clavicle, 4 scapula, 4 cervical spine, 4 intracranial, 4 sternum, 3 maxillofacial, 3 liver, 2 heart/aorta, 2 vascular, 2 urethra/bladder, 2 pneumothorax, and 2 pancreas/common bile duct. DD resulted in 1 death, 6 prolonged intensive care unit stays, 19 operative interventions, and 38 additional interventions. CONCLUSIONS TS is an effective way of evaluating trauma patients for intracranial, cervical spine, chest, abdomen, and pelvic injuries that have the potential to impact morbidity and mortality. The incidence of injuries missed in these crucial areas has been reduced at our institution by the use of this radiographic modality. The most common missed injury remains bowel, and so a high index of suspicion and the tertiary survey must remain a mainstay of therapy.
Neofusicoccum luteum as a pathogen on Tejocote ( Crataegus mexicana )

Tejocote ( Crataegus mexicana ), a small pome crab-apple-like fruit, is becoming economically important in California with increasing production, so consideration of diseases that hinder the yield is important. Diseased trees of tejocote were observed in four orchards of Riverside and San Diego Counties of California. Ten symptomatic/asymptomatic samples were studied from each of the orchards. Five most frequently isolated fungi were identified on the basis of morphological characters and sequence data of the internal transcribed spacer ITS1-5.8S-ITS2 and partial β-tubulin gene. Three isolates were identified as Neofusicoccum luteum and two as Phomopsis sp. Pathogenicity tests were conducted by inoculating detached shoots of healthy tejocote trees. Significant lesions were observed on all shoots inoculated with the three N. luteum isolates (designated UCR1190, UCR1191, and UCR1192), but not on the shoots inoculated with other isolates or the non-inoculated controls. Results indicated that all three N. luteum isolates are aggressive pathogens on tejocote. This pathosystem should be further studied with a goal of designing appropriate disease management strategies.
On the Success of the Successful Aging Paradigm

In “Aging Populations’ Everyday Life Perspectives on Healthy Aging: New Insights for Policy and Strategies at the Local Level,” Naaldenberg, Vaandrager, and Leeuwis (2012) examine lay perspectives of the healthy aging concept, highlighting the many and varied ways in which laypersons experience aging well. However, laypersons are not the only group subject to the many and varied conceptualizations of aging well; researchers have been wrestling with naming conventions and operationalization issues for decades. The ease of labelling the presence of disease stands in stark contrast to the ambiguity of labelling positive states of aging. Within the medical field, specific diagnostic criteria are routinely applied within established protocols leading to determination of the presence or absence of disease. There are obviously exceptions to the rule, but the overarching ability with which a state of disease or illness is described usually has a well-established pedigree. Conversely, when dealing with positive states of aging, current naming conventions used by researchers are ambiguous at best and contradictory at worst. Naaldenberg et al. (2012) acknowledge that healthy aging, their term of choice, is “used alongside related concepts such as active aging, positive aging, and successful aging” (p. 712). Lack of consensus definitions, generalizability, and practical applications for these terms inhibits research.
Urban Adolescents’ Physical Activity Experience, Physical Activity Levels, and Use of Screen-Based Media during Leisure Time: A Structural Model

There is limited understanding of the relationship between physical activity and use of screen-based media, two important behaviors associated with adolescents’ health outcomes. To understand this relationship, researchers may need to consider not only physical activity level but also physical activity experience (i.e., affective experience obtained from doing physical activity). Using a sample predominantly consisting of African and Latino American urban adolescents, this study examined the interrelationships between physical activity experience, physical activity level, and use of screen-based media during leisure time. Data collected using self-report, paper and pencil surveys was analyzed using structural equation modeling. Results showed that physical activity experience was positively associated with physical activity level and had a direct negative relationship with use of non-active video games for males and a direct negative relationship with use of computer/Internet for both genders, after controlling for physical activity level. Physical activity level did not have a direct relationship with use of non-active video games or computer/Internet. However, physical activity level had a direct negative association with use of TV/movies. This study suggests that physical activity experience may play an important role in promoting physical activity and thwarting use of screen-based media among adolescents.
Deuterium Fractionation in the Ophiuchus Molecular Cloud

Aims. We measure the deuterium fraction, RD, and the CO-depletion factor, fd, toward a number of starless and protostellar cores in the L1688 region of the Ophiuchus molecular cloud complex and search for variations based upon environmental differences across L1688. The kinematic properties of the dense gas traced by the N2H+ and N2D+ (1-0) lines are also discussed. Methods. RD has been measured via observations of the J=1-0 transition of N2H+ and N2D+ toward 33 dense cores in different regions of L1688. fd estimates have been done using C17O(1-0) and 850 micron dust continuum emission from the SCUBA survey. All line observations were carried out with the IRAM 30 meter antenna. Results. The dense cores show large (2-40%) deuterium fractions, with significant variations between the sub-regions of L1688. The CO-depletion factor also varies from one region to another (1-7). Two different correlations are found between deuterium fraction and CO-depletion factor: cores in regions A, B2 and I show increasing RD with increasing fd, similar to previous studies of deuterium fraction in pre-stellar cores; cores in regions B1, B1B2, C, E, F and H show a steeper RD-fd correlation, with large deuterium fractions occurring in fairly quiescent gas with relatively low CO freeze-out factors. These are probably recently formed, centrally concentrated starless cores which have not yet started the contraction phase toward protostellar formation. We also find that the deuterium fraction is affected by the amount of turbulence, dust temperature and distance from heating sources in all regions of L1688, although no clear trend is found.
Standard osteopathic manipulative treatment acutely improves gait performance in patients with Parkinson's disease

Abstract Patients with Parkinson's disease exhibit a variety of motor deficits which can ultimately result in complete disability. The primary objective of this study was toquantitatively evaluate the effect of osteopathic manipulative treatment (OMT)on the gait of patients with Parkinson's disease. Ten patients with idiopathicParkinson's disease and a group of eight age-matched normal control subjects ~eresubjected to an analysis of gait before and after a single session of an OMT protocol. A separate group of 10 patients with Parkinson's disease was given asham-control procedure and tested in the same manner. In the treated group ofpatients with Parkinson's disease, statistically significant increases were observedin stride length, cadence, and the maximum velocities of upper and lower extremitiesafter treatment. There were no significant differences observed in the controlgroups. The data demonstrate that a single session of an OMT protocol hasan immediate impact on Parkinsonian gait. Osteopathic manipulation may be aneffective physical treatment method in the management of movement deficits inpatients with Parkinson's disease.
Cost effectiveness and screening interval of lipid screening in Hodgkin's lymphoma survivors.

PURPOSE Survivors of Hodgkin's lymphoma (HL) who received mediastinal irradiation have an increased risk of coronary heart disease. We evaluated the cost effectiveness of lipid screening in survivors of HL and compared different screening intervals. METHODS We developed a decision-analytic model to evaluate lipid screening in a hypothetical cohort of 30-year-old survivors of HL who survived 5 years after mediastinal irradiation. We compared the following strategies: no screening, and screening at 1-, 3-, 5-, or 7-year intervals. Screen-positive patients were treated with statins. Markov models were used to calculate life expectancy, quality-adjusted life expectancy, and lifetime costs. Baseline probabilities, transition probabilities, and utilities were derived from published studies and US population data. Costs were estimated from Medicare fee schedules and the medical literature. Sensitivity analyses were performed. RESULTS Using an incremental cost-effectiveness ratio (ICER) threshold of $100,000 per quality-adjusted life-year (QALY) saved, lipid screening at every interval was cost effective relative to a strategy of no screening. When comparing screening intervals, a 3-year interval was cost effective relative to a 5-year interval, but annual screening, relative to screening every 3 years, had an ICER of more than $100,000/QALY saved. Factors with the most influence on the results included risk of cardiac events/death after HL, efficacy of statins in reducing cardiac events/death, and costs of statins. CONCLUSION Lipid screening in survivors of HL, with statin therapy for screen-positive patients, improves survival and is cost effective. A screening interval of 3 years seems reasonable in the long-term follow-up of survivors of HL.
Influence of Compactive Efforts on Cement- Bagasse Ash Treatment of Expansive Black Cotton Soil

A laboratory study on the influence of compactive effort on expansive black cotton specimens treated with up to 8% ordinary Portland cement (OPC) admixed with up to 8% bagasse ash (BA) by dry weight of soil and compacted using the energies of the standard Proctor (SP), West African Standard (WAS) or “intermediate” and modified Proctor (MP) were undertaken. The expansive black cotton soil was classified as A-7-6 (16) or CL using the American Association of Highway and Transportation Officials (AASHTO) and Unified Soil Classification System (USCS), respectively. The 7day unconfined compressive strength (UCS) values of the natural soil for SP, WAS and MP compactive efforts are 286, 401 and 515kN/m respectively, while peak values of 1019, 1328 and 1420kN/m recorded at 8% OPC/ 6% BA, 8% OPC/ 2% BA and 6% OPC/ 4% BA treatments, respectively were less than the UCS value of 1710kN/m conventionally used as criterion for adequate cement stabilization. The soaked California bearing ratio (CBR) values of the OPC/BA stabilized soil increased with higher energy level from 2, 4 and 10% for the natural soil to Peak values of 55, 18 and 8% were recorded at 8% OPC/4% BA 8% OPC/2% BA and 8% OPC/4% BA, treatments when SP, WAS and MP compactive effort were used, respectively. The durability of specimens was determined by immersion in water. Soils treatment at 8% OPC/ 4% BA blend gave a value of 50% resistance to loss in strength value which is acceptable because of the harsh test condition of 7 days soaking period specimens were subjected instead of the 4 days soaking period that specified a minimum resistance to loss in strength of 80%. Finally An optimal blend of is 8% OPC/ 4% BA is recommended for treatment of expansive black cotton soil for use as a sub-base material. Keywords—Bagasse ash, California bearing ratio, Compaction, Durability, Ordinary Portland cement, Unconfined compressive strength.
The risk factors and time course of sepsis and organ dysfunction after burn trauma.

BACKGROUND Sepsis and organ dysfunction are common and likely contribute to death after burn trauma. We sought to define relationships between sepsis, severe multiple organ dysfunction (MOD), and death after burn trauma. METHODS Adults with > or = 20% total body surface area burns were prospectively enrolled. Information regarding infection, severity of sepsis, and organ failure was collected daily. Risk factors (e.g., age, burn size, shock) were analyzed for their association with severe MOD, complicated sepsis, and death. We characterized the temporal relationship between organ failure and sepsis. RESULTS Of 175 patients, 27% developed severe MOD, 17% developed complicated sepsis, and 22% died. Full-thickness burn size, age, and inhalation injury were associated with MOD, sepsis, and death. Infection preceded MOD in 83% of patients with both. A base deficit of > or = 6 mEq/L at 24 hours after injury was associated with death. CONCLUSION When it occurs, severe MOD is usually preceded by infection. In addition, an elevated base deficit at 24 hours and septic shock are the most important factors associated with and possibly contributing to death after burn trauma.
The epidermal growth factor family has a dual role in deciding the fate of cancer cells

Expression of the epidermal growth factor (EGF) receptors HER1 and HER2 has been implicated in tumour growth and poor survival, whereas expression of HER3 and HER4 has been associated with improved survival of bladder cancer patients. The balance between the expression of the EGF family members may therefore have a role to play in determining the final outcome in cancer cells. To check this, we examined the effect of HER1 activation and inhibition on the expression of the EGF receptors HER3 and HER4 and ligands – the heregulins (HRGs). RT4 bladder cancer cells were treated with 1nM HB‐EGF (known to induce cell proliferation by activating HER1 receptor) and the mRNA content of the two receptors (HER3 and HER4) and their activating ligands (HRG1‐HRG4) was quantified by real time PCR at indicated time‐points. Expressions of HRG1α and HRG1β increased 8‐fold and 9‐fold, respectively, whereas the expressions of HRG2α (4‐fold), HRG2β (2.5‐fold) and HRG4 (3.5‐fold) decreased. In contrast, inhibition of tyrosine kinase activity of HER1 with 5 μM Iressa (a specific inhibitor of HER1) resulted in an increase in mRNA expression of HRG2α (2.5‐fold) and HRG4 (1.5‐fold). In addition, expression of the receptors HER3 (1.5‐fold) and HER4 (2‐fold) was also increased. In conclusion, we demonstrate that activation of the HER1 receptor suppressed the expression of a specific set of HRGs. A decrease in expression of HRG2 and HRG4 during HB‐EGF treatment supports their role in growth inhibition, whereas an increase in HRG1 expression points to a role as a growth stimulatory member of the EGF family.
Programmed cell death‐1 (PD‐1) checkpoint blockade in combination with a mammalian target of rapamycin inhibitor restrains hepatocellular carcinoma growth induced by hepatoma cell–intrinsic PD‐1

Inhibitors of programmed cell death 1 (PD‐1) administered as single agents have resulted in durable tumor regression in advanced cancer patients. However, only a minority of cancer patients respond to anti‐PD‐1 immunotherapy. Here, we show that PD‐1 expression in hepatocellular carcinoma promotes tumor growth independently of adaptive immunity. Knockdown of PD‐1 suppresses tumor growth, whereas PD‐1 overexpression enhances tumorigenesis in immunodeficient xenografted mice. Mechanistically, PD‐1 binds the downstream mammalian target of rapamycin effectors eukaryotic initiation factor 4E and ribosomal protein S6, thus promoting their phosphorylation. Moreover, combining mammalian target of rapamycin inhibition with anti‐PD‐1 antibody treatment results in more durable and synergistic tumor regression than either single agent alone, each of which presents only modest efficacy. Conclusion: Targeting mammalian target of rapamycin pathways in combination with PD‐1 may result in increased antitumor efficacy in cancer patients. (Hepatology 2017;66:1920–1933)