Miracle-dz/UniFAR-FTUs huggingface dataset:
WHAT A HİGH FREQUENCY OF DEFERİPRONE-İNDUCED AGRANULOCYTOSİS İN A TURKİSH POPULATİON OF THALASSEMİA MAJOR

Ozet Deferipronun agranulositoz yapma potansiyeli mevcuttur. Iskenderun Devlet Hastanesi Kalitsal Kan Hastaliklari Merkezi ve Mustafa Kemal Universitesi Tip Fakultesi Hematoloji Servisince takip edilen talasemi major hastalarinin kayitlari incelendi. Onsekiz vaka desferoksamin, bes vaka deferipron ve 21 vaka her ikisini de kullanmaktaydi. Tedavinin ilk yilinda deferipron kullanan 26 hastadan ucunde (%11.5) agranulositoz gelisti. Bu oran, onceki yayinlarda belirtilen agranulositoz gorulme orani olan %0.5-1 ile karsilastirildiginda, arada istatistiksel olarak anlamli bir farkin mevcut oldugu goruldu (p<0.01). Hafif notropeni hicbir vakada gorulmedi ve bu oran da anlamli sekilde dusuktu (%0.0’a karsilik %8.5, p<0.01). Agranulositoz gorulen vakalarin ucu hem desferoksamin hem de deferipron kullanmaktaydi ve vakalarin bir tanesi bayandi. Ayrica, agranulositoz gorulen vakalarin ikisi splenektomiliydi ve hicbir vakada antiHCV pozitifligi tespit edilmedi. Sonuc olarak, kalitimsal faktorler ve desferoksamin ile birlikte kullanimin, deferiprona bagli agranulositoz icin onemli risk faktorleri oldugu ve bayan cinsiyet, gecirilmis splenektomi veya hepatit enfeksiyonlarinin getirdigi risklerin dusuk olabilecegi dusunuldu. Anahtar kelimeler: Talasemi major, artmis demir yuku, desferoksamin, deferipron, ICL 670
Discussion Paper No . 2003 / 25 Trade Liberalization , Agriculture , and Poverty in Low-income Countries

This paper offers an economic assessment of the opportunities and challenges provided by the WTO’s Doha Development Agenda, particularly through agricultural trade liberalization, for low-income countries seeking to trade their way out of poverty. After discussing links between poverty, economic growth and trade, it reports modelling results showing that farm product markets remain the most costly of all goods market distortions in world trade. It focuses on what such reform might mean for countries of South Asia and sub-Saharan Africa in particular, both without and with their involvement in the MTN reform process. What becomes clear is that if those countries want to maximize their benefits from the Doha round, they need also to free up their own domestic product and factor markets so their farmers are better able to take advantage of new market-opening opportunities abroad. Other concerns of low-income countries about farm trade reform also are addressed: whether there would be losses associated with tariff preference erosion, whether food-importing countries would suffer from higher food prices in international markets, whether China’s WTO accession will provide an example of trade reform aggravating poverty via cuts to prices received by Chinese farmers, and the impact on food security and poverty alleviation. The paper concludes with lessons of relevance for low-income countries for their own domestic and trade policies.
3 The acquisition of temporality

Three reasons render the expression of temporality a particularly interesting issue in language acquisition research. Firstly, temporality is a fundamental category of human experience and cognition, and all human languages have developed a wide range of devices to express it. These devices are similar, but not identical, across languages, and this well-defined, or at least well-definable, variability presents the learner with a clear set of acquisitional problems, and allows the researcher to study in which order, and in which way, these problems are approached. Secondly, the expression of temporality in a particular language typically involves the interplay of several means lexical (eg., inherent verb meaning), morphological (e.g., tense marking), syntactic (e.g., position of temporal adverbs), pragmatic (e.g., rules of discourse organisation). This allows the researcher to study how an interacting system, rather than some isolated phenomenon, is acquired. Thirdly, one major category of temporality, tense, is closely linked to the finiteness of the verb, and finiteness in turn is of primordial importance in the development of utterance structure (if the language has finite verbs, as is the case in all languages studied in this project). Hence, the acquisition of tense is tightly linked to the acquisition of syntax. In accordance with the tenets of the entire project, the investigation of temporality had three objectives. It asked:
Tinea Capitis Caused by Trichophyton Rubrum

We present a case of tinea capitis in a four-week-old infant caused by Trichophyton rubrum; the patient was effectively treated with griseofulvin ultramicrosize. Although tinea capitis is the most common fungal infection in children, it is rarely seen in immunocompetent infants. Tinea capitis involves infection of both the hair shaft and pilosebaceous unit, thus mandating treatment with systemic antifungal therapy. ________________________________________________________________________________ * Consultant Department of Dermatology Salmaniya Medical Complex Kingdom of Bahrain ** Consultant Department of Dermatology Mount Sinai School of Medicine New York *** Junior Resident Department of Dermatology Salmaniya Medical Complex Kingdom of Bahrain Email: maryam.alderazi@gmail.com
Two-loop renormalization of multiflavor Pdbl3 theory in six dimensions and the trace anomaly

We use the background-ﬁeld method and the heat kernel to obtain all counterterms to two-loop order of conformally-coupled multiﬂavor φ 3 theory in six spacetime dimensions, deﬁned in curved spacetime and with spacetime-dependent couplings. We also include spacetime-dependent mass terms for completeness. We use these results to write a general expression for the trace anomaly. With the use of Weyl consistency conditions we are able to show that the strong a -theorem for a certain natural candidate quantity ˜ a is violated in this theory, and obtain a three-loop expression for the coeﬃcient a of the Euler term in the anomaly.
ANKYRIN-B AND mTOR COMPLEX 1 IN THE REGULATION OF ELECTRICAL ACTIVITIES IN THE HEART

vi LIST OF FIGURES.xiv LIST OF TABLES. LIST OF ABBREVIATIONS. CHAPTER 1: INTRODUCTION 1.1 Scope of the Dissertation.2 1.2 Hemodynamic Load-Induced Structural and Functional Remodeling.5 1.3 mTOR Signaling in the Heart.8 1.4 Overactive mTORC1 Underlies Electrical Changes in the Brain.12 1.5 Ion Channels and the Adaptor Protein Ankyrin.14 1.6 Ankyrin and the Heart.18 CHAPTER 2: THE DIFFERENTIAL EFFECTS OF PRENATAL AND/OR POSTNATAL RAPAMYCIN ON NEURODEVELOPMENTAL DEFECTS AND COGNITION IN A NEUROGLIAL MOUSE MODEL OF TUBEROUS SCLEROSIS COMPLEX 2.
NMR metabolomic and non ‐ destructive 2 D NMR relaxometry to assess internal quality in apples

NMR can be considered a multi‐scale multidimensional technology in the sense that it provides both spatial insight at macroscopic (MRI) or microscopic level (relaxometry), together with chemical characterization (HR‐MAS). In this study 296 apples (from 4 cultivars) were MRI screened (20 slices per fruit) among which 7 fruits were used for metabolomic study by 1H HR MAS in order to assess various chemical shifts: malic acid, sucrose, glucose, fructose and ethanol. On the first season, tissue samples were taken from the sound and affected apples (near the core, centre and outer part of the mesocarp) belonging to sound and affected locations, while on the second season, tissue samples were focused on the comparison between sound and affected tissue. Beside, MRI and 2D non‐destructive relaxometry (on whole fruits, and localized tissue) where performed on 72 and 12 apples respectively in order to compare features at macroscopic (tissue) and microscopic (subcellular) level. HR MAS shows higher content of α‐glucose, β‐glucose, malic acid and aromatic compounds in watercore affected tissues from both seasons, while sound tissue reflects higher sucrose. Microscopic (subcellular) degradation of tissue varies according to disorder development and is in good accordance with macroscopic characterization with MRI.
Syllable once again . Endogenous or Exogenous ?

Raffaele Caldarelli Open Syllable Once Again. Endogenous or Exogenous? After a brief reply to some critical remarks raised by Mario Enrietti in a paper published in “Studi Slavistici”, VI (2009), the Author tries to explain why Enrietti’s theory of an exogenous, namely Romance origin of the Slavic open syllable structure should be rejected.
Arsenic Incorporation into Garden Vegetables Irrigated with Contaminated Water

Daily vegetable requirement are mostly fulfilled in Bangladesh through homestead garden production which are usually irrigated with arsenic-rich underground water. Garden vegetables grown in arsenic-tainted soil may uptake and accumulate significant amount of arsenic in their tissue. Mean, minimum and maximum arsenic content in some common garden vegetables, e.g. bean, bitter gourd, bottle gourd, brinjal, chilli, green papaya, mint, okra, palwal, potato, red amaranth, string bean and sweet gourd, from an arsenicprone locality of Bangladesh have been assessed. The contribution of vegetable-arsenic in the daily diet was estimated. Correlation with the groundwater arsenic status and statistical significance of variations has been
GROWTH PERFORMANCE, HEMATOLOGY, AND MUSCLE GROWTH IN ISOLEUCINE FED NILE TILAPIA

Artigo Científico: Recebido em 24/08/2016; Aprovado em 17/02/2017 1Universidade Federal da Grande Dourados, Dourados, MS, Brazil. Rodovia Dourados a Itahum, km 12, Aeroporto, CEP: 79804-970. E-mail: dacley_pesca@hotmail.com (author for correspondance). 2Universidade Estadual do Oeste do Paraná – Unioeste, Toledo, PR, Brazil. Rua da Faculdade 645, Jardim Santa Maria, CEP: 85903-000. 3Universidade Estadual de Maringá – UEM, Maringá, PR, Brazil. Avenida Colombo, 5790, Jardim Universitário, CEP: 87020-900. 4Universidade Estadual de Ponta Grossa – UEPG, Ponta Grossa, PR, Brazil. Av. General Carlos Cavalcanti, 4748, Uvaranas, CEP: 84030-900. DESEMPENHO PRODUTIVO, HEMATOLOGIA E CRESCIMENTO MUSCULAR DE TILAPIA DO NILO ALIMENTADAS COM ISOLEUCINA
ASSESSMENT OF UNCERTAINTY IN PLANNING AND DOSE DELIVERY OF PROTON THERAPY IN AN IROC- HOUSTON QA PHANTOM DUE TO VARIABLE CT TECHNIQUE AND PROTON ENERGY

As proton therapy increases in popularity, so does the need for effective quality assurance. Proton therapy institutions participating in NCI funded clinical trials rely heavily on the credentialing and auditing services of IROC-H and therefore the process must be well understood. The purpose of this project is to understand the uncertainties in proton therapy treatment planning for the IROC-H proton phantom QA program due to variations in CT technique and proton energy. It was hypothesized that variations in CT technique and proton energy will alter the delivered dose distributions of typical proton treatments by reducing the percent of passing pixels by 10% using a gamma analysis criteria of ±3%/5mm as measured using a heterogeneous proton QA phantom. A CT phantom used by IROC-H during therapy site visits was scanned using three CT techniques (80, 120, 140kV) with a CT scanner used for proton therapy simulations and irradiated with a passively scattered beam at three energies (140, 200, 250 MeV) to measure, respectively, HU and Relative Linear Stopping Power (RLSP) in order to create HU to RLSP calibration curves for comparison with reference curves as defined by this study. The phantom has proton equivalent materials with a wide variety of HU and RLSPs to allow for the creation of a calibration curve for common tissue equivalent materials. Treatment plans were created for an anthropomorphic proton lung phantom using the various CT technique/ beam energy calibration curves to determine the differences in the dose distributions by performing a gamma analysis. The 3D gamma analysis resulted in a pass rate of 100% for all plans and the 2D gamma analysis resulted in a pass rate above 99%. This result implied the varying treatment plans did not substantially affect the outcome of the dose comparison and therefore rejects the stated hypothesis and further work is needed to investigate the uncertainty present in this QA process.
Atividade antimicrobiana de méis de cinco espécies de abelhas brasileiras sem ferrão Antimicrobial activity of honey from fi ve species of Brazilian stingless bees

The antimicrobial activity of honey produced by Melipona asilvai, Melipona quadrifasciata anthidioides, Friseomelita doederleinei, Tetragonisca angustula and Plebeia sp. were investigated. The agar well diffusion assay demonstrated that all honeys had antibacterial activity against Staphylococcus aureus, but only the samples from M. quadrifasciata anthidioides and F. doederleinei inhibited the growth of Escherichia coli. In the Minimum Inhibitory Concentration determination assay, M. asilvai, M. quadrifasciata anthidioides, F. doederleinei and T. angustula honeys were more active than that from Plebeia sp. for S. aureus and E. coli. The microorganisms Pseudomonas aeruginosa and Candida albicans were resistant to the all native stingless bee honeys in both assays. Honeys were more effective against bacteria than a sugar solution, suggesting that the mechanism for bacterial growth inhibition is not only related to the osmotic effect. The results of antimicrobial activity may explain the popular medicinal use of these honeys in bacterial diseases.
The Amspoort Silts, northern Namib desert (Namibia): formation, age and palaeoclimatic evidence of river-end deposits

Detailed geomorphological and chronological investigations of the NW-Namibian Amspoort Silt formation show that the sediments are typical river-end deposits. This type of endoreic sediment, occuring only in desert margin areas, provides valuable information about the palaeo-environment. In the Hoanib valley, the fine-grained deposits have buried riverine trees. Radiocarbon dating of the wood and luminescence dating of the sediments allow a detailed reconstruction of the aggradation processes. Accumulation started ~10 km downstream of Amspoort around the beginning of the 15th century and ended in the 19th century, some kilometres upstream of Amspoort. This upstream shift of sedimentation during the Little Ice Age was caused by gradually decreasing runoff resulting from aridification of the upper part of the Hoanib river catchment lying east of the Namib desert margin z1.200 m a.s. l. The Amspoort Silt terrace is evidence of palaeo-hydrological fluctuations in NW-Namibia. At present, the Hoanib river erodes deeply into the silty deposits, indicating that NW-Namibia receives more monsoonal rainfall today than during the Little Ice Age. However, this contradicts the hypothesis of a (continual) natural aridification of NW-Namibia (Damaraland, Kaokoveld) since the mid-19th century in the course of global climatic change. Rather, deposition and erosion of the Amspoort Silts indicate that landscape degradation in NW-Namibia is primarily anthropogenically induced and most probably not accelerated by a decrease in precipitation. D 2004 Elsevier B.V. All rights reserved.
The Effect of Enforcement on Firm Finance

This paper analyzes how an enforcement mechanism that resembles a court affects firm finance. We construct a model of enforcement which shows the following: (i) Firm default due to inability to pay and unwillingness to pay are equilibrium phenomena that arise endogenously and co-exist. (ii) The parameters that characterize enforcement have a highly non-linear influence on firm finance. (iii) Equilibrium credit rationing can occur for plausible parameter values. (iv) We identify a new type of credit rationing that is inherent in the underlying legal system. (iv) We provide complete characterizations of the effect of the enforcement parameters on the contract interest rate and the bankruptcy probability. These results help explain recent puzzles in empirical evidence on how the legal environment affects financial structure. JEL Classification Numbers:
Six-Year-Old Child Model in Frontal Sled Test

This paper deals with a demonstration of a six-year-old child model. The model, called Bobby, belongs to a family of human rigid body models, Robby, and was created within the computational environment of the PAM system. First of all, Bobby is updated, the geometry and material properties of the original model are improved, and, in particular, joints, including their characteristics, are redefined. The updated model is tested in a sled test environment. Due to lack of experimental data with child cadavers, the test is compared to an experiment with the six-year-old Anthropomorphic Test Device, published in available literature sources.
ENDOGENOUS CARTEL FORMATION WITH HETEROGENEOUS FIRMS AND DIFFERENTIATED PRODUCTS

Real-world collusive agreements do not necessarily include all firms that are active in the cartelized industry. Often, cartels are formed by asymmetric firms offering products that are not completely homogenous. This article endogenizes the process of cartel formation in a simulation model where firms are asymmetric in marginal costs and offer differentiated products. After a cartel is formed, it may be destabilized if the evolution of costs produces a sufficiently asymmetric cost-structure. In this case, the cartelists use price wars to stabilize the collusive agreement. Cartels arise as the outcome of a dynamic formation game in mixed strategies. This game is complex because of firms' asymmetry and the multitude of possible cartel-compositions. I show that the Nash-equilibrium of this game can be obtained efficiently by a Differential Evolution stochastic optimization algorithm. It turns out that large firms gain more from colluding than small firms. Nevertheless, large firms choose a lower probability of joining the cartel.
Matrix-leukocyte interactions in liver ischemia-reperfusion injury.

Hepatic ischemia and reperfusion injury (IRI) remains an important challenge in clinical orthotopic liver transplantation (OLT). Tissue inhibitor of metalloproteinase-1 (TIMP-1) is the major endogenous regulator of matrix metalloproteinase-9 (MMP-9). In this study, we investigated the functional significance of TIMP-1 expression in a wellestablished mouse model of partial liver IRI. Compared to wild-type mice, TIMP-1 mice showed further impaired liver function and histological preservation after IRI. Notably, TIMP-1 deficiency led to lethal liver IRI, as over 60% of the TIMP-1 mice died postreperfusion, whereas all TIMP-1 mice recovered and survived surgery. Lack of TIMP-1 expression was accompanied by markedly high levels of MMP-9 activity, which facilitates leukocyte transmigration across vascular barriers in hepatic IRI. Indeed, TIMP1 livers were characterized by massive leukocyte infiltration and by upregulation of proinflammatory mediators, including TNF, IFN, and iNOS, post-IRI. The inability of TIMP-1 mice to express TIMP-1 increased the levels of active caspase-3 and depressed the expression of Bcl-2 and the phosphorylation of Akt, emphasizing an important role for TIMP-1 expression on hepatocyte survival. Using independent parameters of regeneration, 5-bromodeoxyuridine (BrdU) incorporation, proliferating cell nuclear antigen (PCNA) expression, and histone H3 phosphorylation, we provide evidence that hepatocyte progression into S phase and mitosis was impaired in TIMP-1 deficient livers after IRI. Inhibition of the cell cycle progression by TIMP-1 deficiency was linked to depressed levels of cyclins-D1 and -E and to disrupted c-Met signaling pathway, as evidenced by reduced phosphorylated c-Met expression and elevated c-Met ectodomain shedding post-liver IRI. In conclusion, these results support a critical protective function for TIMP-1 expression on promoting survival and proliferation of liver cells and on regulating leukocyte recruitment and activation in liver IRI. Sérgio Miguel Duarte PhD Thesis
Gas velocity characteristics from a nozzle and a series of nozzles in a confined cylindrical vessel

Gas distribution from a nozzle and a series of nozzles has been studied. The simple axisymmetric, round, free jet and multijet and two dimensional, free jet and multijet were investigated by employing a set up with one nozzle, three and five nozzle series and measured by using a pitot tube. The results show that the variation in the centreline mean velocity decay (decay rate) of the one circular nozzle, three and five circular nozzle series follows inverse law decay, x \ whereas the variation in the centreline mean velocity decay (decay rate) of the one rectangular nozzle, three and five rectangular nozzle series follows an inverse square root law decay, The mean velocity profiles in the centre plane, z = 0, for circular and rectangular type of the one nozzle and the three and five nozzle series show a continuous broadening of the velocity of the jet in the different downstream stations and across the submerged jet.
What is the effect of an aerobic exercise program on pulmonary function for children and adolescents suffering from cystic fibrosis ? Measured in forced vital capacity and forced expiratory volume in one second .-A Literature Review

Introduction: Cystic fibrosis is a life-limiting, inherited multi-organ disorder affecting Caucasians in the world today. The respiratory system is most often involved, which results in a limited life-span and decreased quality of life. Exercise is an important part of the therapy for cystic fibrosis; therefore the aim of this research was to determine the effect of aerobic exercise therapy on pulmonary function in children and adolescents suffering from cystic fibrosis. Method: An electronic search was performed in Pub Med, The Cochrane Library and Physiotherapy Evidence Database. The databases were consulted using the search terms; cystic fibrosis, aerobic exercise program and pulmonary function with a combination and variation of the search terms. Included in this research were studies with children and adolescents with a confirmed diagnosis of cystic fibrosis, younger than 20 years old; participating in an aerobic exercise program, for a minimum of 12 days. Only studies which reported outcome measures on pulmonary function were included. Results: The electronic search resulted in 10 studies which met the set inclusion and exclusion criteria. The majority of the included studies reported significant findings in the change of pulmonary function. There is moderate and limited evidence to support that an aerobic exercise program is effective for improvements in pulmonary function. All of the included studies resulted in improvements, or delayed the progression of the disease and its negative effect on the pulmonary function. Conclusion: An aerobic exercise program should remain an important part of the therapy program for children suffering from cystic fibrosis, because evidence shows that an aerobic exercise program does have a positive effect on pulmonary function for children suffering from cystic fibrosis.
PHYSICAL REVIEW B 97, 075117 (2018) Devil’s staircases without particle-hole symmetry

We present and analyze spin models with long-range interactions whose ground state features a so-called devil’s staircase and where plateaus of the staircase are accessed by varying two-body interactions. This is in contrast to the canonical devil’s staircase, for example, occurring in the one-dimensional Ising model with long-range interactions, where typically a single-body chemical potential is varied to scan through the plateaus. These systems, moreover, typically feature a particle-hole symmetry which trivially connects the hole part of the staircase (filling fraction f 1/2) to its particle part (f 1/2). Such symmetry is absent in our models and hence the particle sector and the hole sector can be separately controlled, resulting in exotic hybrid staircases.