Miracle-dz/UniFAR-FTUs huggingface dataset:
Novel cancer antigens for personalized immunotherapies: latest evidence and clinical potential

The clinical success of monoclonal antibody immune checkpoint modulators such as ipilimumab, which targets cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), and the recently approved agents nivolumab and pembrolizumab, which target programmed cell death receptor 1 (PD-1), has stimulated renewed enthusiasm for anticancer immunotherapy, which was heralded by Science as ‘Breakthrough of the Year’ in 2013. As the potential of cancer immunotherapy has been recognized since the 1890s when William Coley showed that bacterial products could be beneficial in cancer patients, leveraging the immune system in the treatment of cancer is certainly not a new concept; however, earlier attempts to develop effective therapeutic vaccines and antibodies against solid tumors, for example, melanoma, frequently met with failure due in part to self-tolerance and the development of an immunosuppressive tumor microenvironment. Increased knowledge of the mechanisms through which cancer evades the immune system and the identification of tumor-associated antigens (TAAs) and negative immune checkpoint regulators have led to the development of vaccines and monoclonal antibodies targeting specific tumor antigens and immune checkpoints such as CTLA-4 and PD-1. This review first discusses the established targets of currently approved cancer immunotherapies and then focuses on investigational cancer antigens and their clinical potential. Because of the highly heterogeneous nature of tumors, effective anticancer immunotherapy-based treatment regimens will likely require a personalized combination of therapeutic vaccines, antibodies and chemotherapy that fit the specific biology of a patient’s disease.
Modelling tourism demand volatility using a seasonal autoregressive integrated moving average autoregressive conditional heteroscedasticity model for Victoria Falls Rainforest arrivals in Zimbabwe

Accurate tourism volatility forecasts for popular tourist destinations, like the Victoria Falls Rainforest, are vital to tourism destination managers and policymakers. The Victoria Falls Rainforest in Zimbabwe is under the town of Victoria Falls and is one of the natural wonders of the world. The rainforest has many exceptional plant species not common in the region and hence attracts many tourists. Financial, political and economic environments differently affect the Zimbabwean tourism industry, as evidenced by large tourist arrival fluctuations. Previous research focused more on tourism determinants than tourism volatilities. Researchers noted political instability and exchange rates as the major Zimbabwean tourism determinants. Estimates of the Victoria Falls Rainforest tourist arrival volatilities are projected using the monthly tourist arrival figures from the Zimbabwe Parks and Wildlife Management Authority and Zimbabwe Tourism Authority. The first difference of logarithmic transformed series is stationary. The univariate SARIMA(2,1,0)(2,0,0)12-ARCH(1) model fits extremely well and provides an informative out-of-sample volatility forecast because it captures tourism volatility effects, dynamics and non-linearity of conditional variances. The results indicate that positive tourism shocks affect tourist arrival volatility positively. Volatility estimates indicated minimal uncertainty in the first half of the forecasted year and then became constant throughout the year. This encourages the continuation of the implementation of new favourable policies and marketing strategies by the government and tourism destination managers to keep the destination distinctive and attractive. The New Zimbabwe political dispensation is likely to enhance investment opportunities at the Victoria Falls Rainforest as a destination because of minimal uncertainties exhibited by volatility forecasts. Potential employment creation, improved economic environment and other positives are some of the expectations from the model results.
In vitro 
induction of functional allergen‐specific CD4+ CD25high Treg cells in horses affected with insect bite hypersensitivity

Insect bite hypersensitivity (IBH) is a recurrent allergic dermatitis of horses with similarities to human atopic eczema, caused by bites of insects of the genus Culicoides. Previous studies suggested a dysregulated T cell tolerance to Culicoides allergen in IBH‐affected horses.
Suppression of Tumor Growth by Palm Tocotrienols Via the Attenuation of Angiogenesis

Previous studies have revealed that tocotrienol-rich fractions (TRF) from palm oil inhibit the proliferation and the growth of solid tumors. The anticancer activity of TRF is said to be caused by several mechanisms, one of which is antiangiogenesis. In this study, we looked at the antiangiogenic effects of TRF. In vitro investigations of the antiangiogenic activities of TRF, δ -tocotrienol ( δ T3), and α -tocopherol ( α Toc) were carried out in human umbilical vein endothelial cells (HUVEC). TRF and δ T3 significantly inhibited cell proliferation from 4 μ g/ml onward ( P < 0.05). Cell migration was inhibited the most by δ T 3 at 12 μ g/ml. Anti-angiogenic properties of TRF were carried out further in vivo using the chick embryo chorioallantoic membrane (CAM) assay and BALB/c mice model. TRF at 200 μ g/ml reduced the vascular network on CAM. TRF treatment of 1 mg/mouse significantly reduced 4T1 tumor volume in BALB/c mice. TRF significantly reduced serum vascular endothelial growth factor (VEGF) level in BALB/c mice. In conclusion, this study showed that palm tocotrienols exhibit anti-angiogenic properties that may assist in tumor regression.
Extreme cyclone events in the Arctic: Wintertime variability and trends

Typically 20–40 extreme cyclone events (sometimes called ‘weather bombs’) occur in the Arctic North Atlantic per winter season, with an increasing trend of 6 events/decade over 1979–2015, according to 6 hourly station data from Ny-Ålesund. This increased frequency of extreme cyclones is consistent with observed significant winter warming, indicating that the meridional heat and moisture transport they bring is a factor in rising temperatures in the region. The winter trend in extreme cyclones is dominated by a positive monthly trend of about 3–4 events/decade in November–December, due mainly to an increasing persistence of extreme cyclone events. A negative trend in January opposes this, while there is no significant trend in February. We relate the regional patterns of the trend in extreme cyclones to anomalously low sea-ice conditions in recent years, together with associated large-scale atmospheric circulation changes such as ‘blockinglike’ circulation patterns (e.g. Scandinavian blocking in December and Ural blocking during January–February).
How different CSR dimensions impact organization-employee relationships

Purpose Drawing on interdisciplinary insights from stakeholder theory, relationship management and organizational justice, the purpose of this paper is to examine corporate social responsibility (CSR) from an internal and relational perspective. Specifically, it examines the effects of CSR in overall as well as the discretionary, ethical, legal and economic CSR dimensions on organization–employee relationships, respectively. The moderating role of employees’ perceived CSR-culture fit on these effects was also explored. Design/methodology/approach An online survey was conducted with 303 participants from the USA who were full-time employees at for-profit organizations. Findings Results indicate that CSR performance in overall positively influences organization–employee relationships, and such effect is amplified as employees’ perceived CSR-culture fit increases. Discretionary and ethical CSR positively influence organization–employee relationships, but perceived CSR-culture fit only amplifies the influence from ethical CSR. For legal and economic CSR, the effects on organization–employee relationships are only significant when perceived CSR-culture fit is high. Research limitations/implications This study extends the body of knowledge of CSR and internal relationship management. However, the limitations regarding the factors from culture, business sectors and organizational setting should be addressed in future studies through both quantitative and qualitative approaches. Originality/value This study provides a comprehensive understanding of the effects from four different CSR dimensions on organization–employee relationships as well as how such effects were moderated by employees’ perceived CSR-culture fit. Integrating interdisciplinary theoretical frameworks, this study offers insights for corporate communications and public relations professionals on how to effectively build and cultivate relationships with employees through different dimensions of CSR.
Consensus Statements on the BAHA System: Where Do We Stand at Present?

After more than 25 years of clinical experience, the BAHA (bone-anchored hearing aid) system is a well-established treatment for hearing-impaired patients with conductive or mixed hearing loss. Owing to its success, the use of the BAHA system has spread and the indications for application have gradually become broader. New indications, as well as clinical applications, were discussed during scientific roundtable meetings in 2004 by experts in the field, and the outcomes of these discussions are presented in the form of statements. The issues that were discussed concerned BAHA surgery, the fitting range of the BAHA system, the BAHA system compared to conventional devices, bilateral application, the BAHA system in children, the BAHA system in patients with single-sided deafness, and, finally, the BAHA system in patients with unilateral conductive hearing loss.
Co‐ordinate expression of virulence genes during swarm‐cell differentiation and population migration of Proteus mirabilis

The uropathogenic Gram‐negative bacterium Proteus mirabilis exhibits a form of multicellular behaviour termed swarming, which involves cyclical differentiation of typical vegetative cells into filamentous, multi‐nucleate, hyperflagellate swarm cells capable of rapid and co‐ordinated population migration across surfaces. We observed that differentiation into swarm cells was accompanied by substantial increases in the activities of intracellular urease and extracellular haemolysjn and metalloprotease, which are believed to be central to the pathogenicity of P. mirabills. In addition, the ability of P. mirabilis to invade human urothelial cells in vitro was primarily a characteristic of differentiated swarm cells, not vegetative cells. These virulence factor activities fell back as the cells underwent cyclical reversion to the vegetative form (consolidation), in parallel with the diagnostic modulation of flagellin levels on the cell surface. Control cellular alkaline phosphatase activities did not increase during differentiation or consolidation. Non‐flagellated, non‐motile transposon insertion mutants were unable to invade urothelial cells and they generated only low‐level activities of haemolysin, urease and protease (0–10% of wild type). Motile mutants unable to differentiate into swarm cells were comparably reduced in their haemolytic, ureolytic and invasive phenotypes and generated threefold less protease activity. Mutants that were able to form swarm cells but exhibited various aberrant patterns of swarming migration produced wild‐type activities of haemotysin, urease and protease, but their ability to enter urothelial cells was three‐ to 10‐fold lower. Analysis of haemolysin (hpmA) transcripts showed that during swarm cell differentiation there was a c. 50‐fold increase in the level of the predicted major 5.2 kb and minor 6.9 kb mRNAs transcribed from the hpm operon, and assay of mRNA complimentary to urease (ureC) and flagellin (fliC) gene sequences confirmed that modulation of virulence factor activity during the swarming cycle resulted from differential expression of virulence genes in parallel with fliC gene expression. Hybridization of stage‐specific mRNA with 30 random, non‐overlapping chromosomal gene probes provided no evidence for universal changes in the expression of the P. mirabiis genome, suggesting that differential virulence gene expression may be a specific strategy.
Career paths and mobility in the Swedish hospitality sector

ABSTRACT How career paths are interpreted and conceptualised by hospitality workers and industry representatives remains underexplored in current literature. In this paper, we highlight and discuss sector-specific and contextual factors that influence the possibility of establishing a career within the Swedish hospitality sector. The paper uses interviews with hotel managers, who describe and discuss motivations and choices made throughout their own careers and interviews with young (former) seasonal hospitality workers who describe and reflect on their future plans and work-life experience. Additional data are derived through observations at national seminars and meetings for representatives from the Swedish tourism and hospitality industry, where issues of competence and careers were discussed. The findings indicate that the shaping of career paths within the hospitality sector is influenced by two normative and discursively produced ‘truths’ about career paths in the hospitality sector: the importance of internal knowledge transfer and the importance of high mobility. These narratives impose expectations on individuals to be mobile, to change jobs frequently and to work their way from the bottom-up within the industry, and are based on a presumption of a diversified and dense local hospitality labour market. However, since the conditions are different due to contextual, geographical features of labour market size and structure, attractiveness of places, etc., these expectations are difficult to fulfil in places other than in larger urban areas. These normative assumptions of what a successful hospitality career is also have consequences for the development of the hospitality sector as external influences of competence from other sectors and higher education are not seen as valuable, which makes the sector self-contained and not open to external, potentially innovative knowledge.
Effect of the FruR Regulator on Transcription of the pts Operon in Escherichia coli(*)

The promoters of the pts operon of Escherichia coli are controlled by the cyclic AMP receptor protein (CRP) complexed with cAMP (CRP•cAMP). In addition, glucose stimulates pts operon expression in vivo. The pts promoter region has a fructose repressor (FruR)-binding site (the FruR box) that partially overlaps with one of the CRP•cAMP-binding sites. The effects of the pleiotropic transcriptional regulator FruR on pts operon expression were studied to determine whether the in vivo glucose effect on pts operon expression is mediated by FruR. In vitro, FruR can repress P1b transcription, which is activated by CRP•cAMP, and restore P1a transcription, which is repressed by CRP•cAMP. FruR can displace CRP•cAMP from its binding site in the presence of RNA polymerase even though FruR and CRP•cAMP can bind simultaneously to their partially overlapping binding sites in the absence of RNA polymerase. FruR had very little effect on the transcription of the P0 promoter, which is most important for regulation by glucose. Consistent with the in vitro results, pts P0 transcription did not increase as much in cells grown in the presence of fructose or in fruR mutant cells as in cells grown in the presence of glucose. These results suggest that FruR alone does not mediate the in vivo glucose effect on pts operon expression.
The Voice of the People: Reasons Laypersons Support K--12 Art Education.

In the midst o f generating theory for classrooms, philosophizing on the meaning and relevance o f art education, determining policy and practices for classrooms, even providing advocacy literature in favor o f art education, few references have been made to laypersons’ ideas about art education. Lest the layperson (non-art education professional)—the “human element” [Pinar, Reynolds, Slattery, & Taubman, 1995, p. 102)-be overlooked, disregarded, and/or marginalized from considerations about art education, their ideas must be solicited, honored, and respected. Since the mission o f art education is to educate future laypersons and not (necessarily) future artists, members of the profession as well as policymakers for education should be informed o f what laypersons are thinking about art in schools. The uniqueness o f this study as well as its purpose was the solicitation of laypersons’ ideas about art education in the everyday, informal language o f the layperson. In addition to considerations o f literature, histories, and other related sources, this study consisted of randomly surveying 337 persons in six cities throughout the United States. O f the respondents to the questionnaire/survey, 88% indicated that they support art education as a required subject in the K 12 public school curriculum. In the open-ended sections o f the questionnaire/survey, these laypersons communicated highly sophisticated, post-modern ideas which included not only a strong sense o f self in society (Dewey, 1934), but support for art education (a.) for self-expression and social expression and (b.) as a vehicle for understanding and honoring the societies and cultures o f self and others.
Telomerase reverse transcriptase promotes cardiac muscle cell proliferation, hypertrophy, and survival

Cardiac muscle regeneration after injury is limited by “irreversible” cell cycle exit. Telomere shortening is one postulated basis for replicative senescence, via down-regulation of telomerase reverse transcriptase (TERT); telomere dysfunction also is associated with greater sensitivity to apoptosis. Forced expression of TERT in cardiac muscle in mice was sufficient to rescue telomerase activity and telomere length. Initially, the ventricle was hypercellular, with increased myocyte density and DNA synthesis. By 12 wk, cell cycling subsided; instead, cell enlargement (hypertrophy) was seen, without fibrosis or impaired function. Likewise, viral delivery of TERT was sufficient for hypertrophy in cultured cardiac myocytes. The TERT virus and transgene also conferred protection from apoptosis, in vitro and in vivo. Hyperplasia, hypertrophy, and survival all required active TERT and were not seen with a catalytically inactive mutation. Thus, TERT can delay cell cycle exit in cardiac muscle, induce hypertrophy in postmitotic cells, and promote cardiac myocyte survival.
Alternative Specifications of Fisher Hypothesis: An Empirical Investigation

Fisher hypothesis provides theoretical framework for the study of relationship between nominal interest rate and inflation. It assumes one to one direct relationship between nominal interest rate and inflation. Modifications to this model are explained by Mundell effect, Phillips curve and Friedman effect , Levi and Makin effect, Darby effect and Carmichael and Stebbing effect (Inverted Fisher Hypothesis). The objective of this paper is to explore the Fisher hypothesis and its alternative specifications using IFS Panel data set and applying General to Specific Methodology . Findings of this paper show that Inverted Fisher hypothesis holds in above average money supply GDP countries. Full Fisher effect is present only when Phillips curve effect and Friedman effect are also present in below average money supply GDP countries.
Processing Long Queries Against Short Text

Many real applications in real-time news stream advertising call for efficient processing of long queries against short text. In such applications, dynamic news feeds are regarded as queries to match against an advertisement (ad) database for retrieving the k most relevant ads. The existing approaches to keyword retrieval cannot work well in this search scenario when queries are triggered at a very high frequency. To address the problem, we introduce new techniques to significantly improve search performance. First, we devise a two-level partitioning for tight upper bound estimation and a lazy evaluation scheme to delay full evaluation of unpromising candidates, which can bring three to four times performance boosting in a database with 7 million ads. Second, we propose a novel rank-aware block-oriented inverted index to further improve performance. In this index scheme, each entry in an inverted list is assigned a rank according to its importance in the ad. Then, we introduce a block-at-a-time search strategy based on the index scheme to support a much tighter upper bound estimation and a very early termination. We have conducted experiments with real datasets, and the results show that the rank-aware method can further improve performance by an order of magnitude.
Lateral pharyngoplasty reduces nocturnal blood pressure in patients with obstructive sleep apnea

To compare the values of 24‐hour ambulatory blood pressure monitoring (ABPM) in patients with obstructive sleep apnea (OSA), before and after lateral pharyngoplasty, and to investigate the influence of pre‐ and post‐treatment polysomnographic and anthropometric variations on changes in ABPM.
Chronic total occlusions in the superficial femoral artery: A novel strategy using a 1.5 mm J‐tip hydrophilic guidewire with an over‐the‐wire balloon catheter under ultrasound guidance

Chronic total occlusions in the superficial femoral artery (SFA) are the longest and straightest lesions in the whole body. This presents additional technical challenges and the inability to cross the occluded lesion is a common cause of procedural failure in these percutaneous interventions. The objective of this study was to investigate the usefulness of a strategy using a hydrophilic 1.5 mm J‐tip 0.035″ guidewire with an over‐the‐wire balloon catheter under ultrasound guidance for chronic total occlusions in the SFA. This strategy was performed in 32 consecutive patients (36 limbs). Average occlusion length was 17 ± 10 cm (3–40 cm). The crossover approach was performed in 26 cases (72%); in the remaining 10 cases, the antegrade ipsilateral approach was selected. The technical success rate was 92% (32/36). A secondary popliteal artery approach was performed in the three failed limbs and was successful in two limbs, increasing the final technical success rate to 97%. This novel procedure may be considered the preferred strategy for intervening in chronic total occlusions in the SFA. © 2005 Wiley‐Liss, Inc.