Miracle-dz/UniFAR-FTUs huggingface dataset:
Risk Factors for Lateral Meniscus Posterior Root Tears in the Anterior Cruciate Ligament–Injured Knee: An Epidemiological Analysis of 3956 Patients From the SANTI Study Group

Background: Lateral meniscus posterior root tears (LMPRTs) result in loss of hoop forces and significant increases in tibiofemoral contact pressures. Preoperative imaging lacks reliability; therefore, holding an appropriate index of suspicion, based on the epidemiology of and risk factors for LMPRT, may reduce the rate of missed diagnoses. Purpose: The primary objectives of this study were to evaluate the incidence of and risk factors for lateral meniscus root lesions in a large series of patients undergoing anterior cruciate ligament (ACL) reconstruction. Study Design: Case-control study; Level of evidence, 3. Methods: All patients who underwent primary or revision ACL reconstruction by a single surgeon between January 2011 and April 2018 were considered for study eligibility. From this overall population, all patients who underwent repair of an LMPRT were identified. The epidemiology of LMPRT was defined by the incidence within the study population, stratified by key demographic parameters. Potentially important risk factors for the presence of LMPRT were evaluated in multivariate logistic regression analysis. Results: A total of 3956 patients undergoing ACL reconstruction were included in the study. An LMPRT was identified and repaired in 262 patients (6.6%). Multivariate analyses demonstrated that significant risk factors for LMPRT included a contact sports injury mechanism (7.8% incidence with contact sport mechanism vs 4.5% with noncontact mechanism; odds ratio, 1.69; 95% CI, 1.266-2.285; P < .001) and the presence of a medial meniscal tear (7.9% incidence with medial meniscal tear vs 5.8% without; odds ratio, 1.532; 95% CI, 1.185-1.979; P < .001). Although the incidence of LMPRT in male patients (7.3%) was higher than in females (4.8%), this was not significant in multivariate analysis (P = .270). Patient age, revision ACL reconstruction, and a preoperative side-to-side laxity difference ≥6 mm were not significant risk factors for LMPRT. Conclusion: The incidence of LMPRT was 6.6% in a large series of patients undergoing ACL reconstruction. Participation in contact sports and the presence of a concomitant medial meniscal tear were demonstrated to be important independent risk factors. Their presence should raise the index of suspicion for this injury pattern.
Quantitative Proteomic Analysis of Castor (Ricinus communis L.) Seeds During Early Imbibition Provided Novel Insights into Cold Stress Response

Early planting is one of the strategies used to increase grain yield in temperate regions. However, poor cold tolerance in castor inhibits seed germination, resulting in lower seedling emergence and biomass. Here, the elite castor variety Tongbi 5 was used to identify the differential abundance protein species (DAPS) between cold stress (4 °C) and control conditions (30 °C) imbibed seeds. As a result, 127 DAPS were identified according to isobaric tag for relative and absolute quantification (iTRAQ) strategy. These DAPS were mainly involved in carbohydrate and energy metabolism, translation and posttranslational modification, stress response, lipid transport and metabolism, and signal transduction. Enzyme-linked immunosorbent assays (ELISA) demonstrated that the quantitative proteomics data collected here were reliable. This study provided some invaluable insights into the cold stress responses of early imbibed castor seeds: (1) up-accumulation of all DAPS involved in translation might confer cold tolerance by promoting protein synthesis; (2) stress-related proteins probably protect the cell against damage caused by cold stress; (3) up-accumulation of key DAPS associated with fatty acid biosynthesis might facilitate resistance or adaptation of imbibed castor seeds to cold stress by the increased content of unsaturated fatty acid (UFA). The data has been deposited to the ProteomeXchange with identifier PXD010043.
Muscular Morphomechanical Characteristics After an Achilles Repair

Background: The purpose of the study was to compare the morphomechanical and functional characteristics during maximal isometric, concentric, and eccentric contractions in the legs of patients that underwent unilateral Achilles tendon repair with those in their noninjured control legs. Methods: Twenty participants (median age = 38.2 years; range, 21.1-57.3 years) who underwent Achilles repair between 3 and 12 months ago were recruited with the following measures: (1) mechanical stiffness of the aponeurosis and (2) electromyography and medial gastrocnemius fascicle angle and length, standing muscle and tendon length, and height of heel rise with isometric contraction. Results: Compared to the noninjured legs, the repaired legs showed less resting fascicle length, standing muscle length, isometric plantarflexion torque, and heel raise distance (Ps ranged between .044 and <.001). During the concentric and eccentric phases of the raising and lowering test, the repaired legs demonstrated less fascicle length (P ≤ .028) but greater tendinous tissue length (Ps ranged between .084 and <.001) and fascicle angle (Ps ranged between .247 and .008) and fewer change magnitudes of the fascicle length and tendinous tissue length (P ≤ .003). The change magnitudes of the morphological characteristics showed correlations with the torque or distance. Conclusion: Selecting the appropriate surgical repair and rehabilitation for Achilles tendon ruptures is recommended for restoring the length and mechanical strength of the muscle-tendon unit of plantar-flexion muscles. Level of Evidence: Level III, comparative study.
Retrograde Intrarenal Surgery vs. Percutaneous Nephrolithotomy vs. Extracorporeal Shock Wave Lithotripsy for Lower Pole Renal Stones 10-20 mm : A Meta-analysis and Systematic Review.

PURPOSE To conduct a comprehensive meta-analysis of existing evidence to quantify and compare the safety and efficacy of PCNL, RIRS and ESWL for lower pole renal stones 10-20mm. MATERIALS AND METHODS We conducted a systematic literature search in the EMBASE, MEDLINE, Cochrane databases and Google Scholar to identify relevant studies published in English up to May 2018. Literature reviewed included meta-analyses, and randomized and nonrandomized studies. The subject in the management of PCNL, RIRS and ESWL of studies being patients who had lower pole renal stones 10-20mm were selected. The odd ratio (OR) and mean difference(MD) with its 95% confidence interval (CI) using fixed-or-random-model were calculated to estimate the safety and efficacy of PCNL, RIRS and ESWL for lower pole renal stones 10-20mm. Two reviewers independently assessed the quality of all included studies, and the RevMan 5.3 software was used to analyze the included studies. RESULTS Three randomized controlled trials and five retrospective case control studies were included, involving a total of 1615 patients in our meta-analysis. Our results suggest that, for lower pole renal stones 10-20mm, PCNL has a great advantage to RIRS(OR=1.95? 95% CI? 1.22-3.12? P =.005? I2 = 39%) and ESWL(OR=0.22? 95% CI? 0.15-0.34? P <.00001? I2 = 0%) in stone-free rate. Comparing PCNL(MD=-24.97? 95% CI? -40.90--9.04? P=.002; I2 = 76%) (MD=-2.43? 95% CI:-4.70--0.17? P=.04? I2 = 99%) and RIRS(MD=-15.39? 95% CI? -25.54--5.25? P=.003? I2 = 99%) (MD=-0.95? 95% CI: -1.29--0.61? P<.00001? I2 = 96%), ESWL owns some advantages in shorter operative time and hospital stay. Both of PCNL (OR=70.21,95%CI:25.01-197.11,P<.00001) (OR=4.01,95%CI:2.04-7.89, P<.0001) and RIRS (OR=32.31,95%CI:18.39-56.76,P<.00001? I2=0%) (OR=3.06, 95%CI:1.94-4.84,P<.00001? I2=19%) have some strong points in lower retreatment rate and auxiliary procedure rate comparing ESWL, but no statistical significant difference is found between them(OR=0.46,95% CI:0.15-1.42,P =.18? I2=0%)(OR=0.75,95% CI:0.35-1.59,P =.45). About complication rate, there's no statistical significant difference found in PCNL(OR=1.42, 95%CI:0.91-2.21,P=.12? I2=0%), RIRS (OR=0.74,95%CI:0.51-1.07,P=.11? I2=30%) and ESWL(OR=0.41,95% CI:0.16-1.09,P=.07,I2=70%). CONCLUSION Both of PCNL and RIRS offer a longer operative time, the lower retreatment rate and auxiliary procedure rate while PCNL has the longest hospital stay and the highest SFR. However, ESWL is confirmed to have the lowest SFR, the higher retreatment rate and auxiliary procedure rate, but a shorter operative time and the shortest hospital stay. The overall complication rates among the three therapies are comparable.
The impact of stress on epidermal barrier function: an evidence‐based review

The epidermal barrier functions to limit skin infection and inflammation by inhibiting irritant and immunogen invasion. Abundant evidence suggests that psychological stress stemming from crowding, isolation, nicotine smoking, insomnia, mental arithmetic tasks, physical pain, real‐life stressors (examinations and marital strain) and lack of positive personality traits may impart both acute and chronic epidermal dysfunction.
Involvement of adenosine A1 receptor in electroacupuncture-mediated inhibition of astrocyte activation during neuropathic pain

ABSTRACT Neuropathic pain is a chronic pain condition caused by damage or dysfunction of the central or peripheral nervous system. Electroacupuncture (EA) has an antinociceptive effect on neuropathic pain, which is partially due to inhibiting astrocyte activation in the spinal cord. We found that an intrathecal injection of 8-cyclopentyl-1,3-dipropylxanthine (DPCPX), a selective adenosine A1 receptor antagonist, reversed the antinociceptive effects of EA in a chronic constriction injury-induced neuropathic pain model. The expression of GFAP in L4-L6 spinal cord was significantly upgraded, while DPCPX suppressed the effect of the EA-mediating inhibition of astrocyte activation, as well as wiping out the EA-induced suppression of cytokine content (TNF-α). These results indicated that the adenosine A1 receptor is involved in EA actions during neuropathic pain through suppressing astrocyte activation as well as TNF-α upregulation of EA, giving enlightenment to the mechanisms of acupuncture analgesia and development of therapeutic targets for neuropathic pain.
Mutated nucleophosmin 1 as immunotherapy target in acute myeloid leukemia

The most frequent subtype of acute myeloid leukemia (AML) is defined by mutations in the nucleophosmin 1 (NPM1) gene. Mutated NPM1 (&Dgr;NPM1) is an attractive target for immunotherapy, since it is an essential driver gene and 4 bp frameshift insertions occur in the same hotspot in 30%–35% of AMLs, resulting in a C-terminal alternative reading frame of 11 aa. By searching the HLA class I ligandome of primary AMLs, we identified multiple &Dgr;NPM1-derived peptides. For one of these peptides, HLA-A*02:01–binding CLAVEEVSL, we searched for specific T cells in healthy individuals using peptide-HLA tetramers. Tetramer-positive CD8+ T cells were isolated and analyzed for reactivity against primary AMLs. From one clone with superior antitumor reactivity, we isolated the T cell receptor (TCR) and demonstrated specific recognition and lysis of HLA-A*02:01–positive &Dgr;NPM1 AML after retroviral transfer to CD8+ and CD4+ T cells. Antitumor efficacy of TCR-transduced T cells was confirmed in immunodeficient mice engrafted with a human AML cell line expressing &Dgr;NPM1. In conclusion, the data show that &Dgr;NPM1-derived peptides are presented on AML and that CLAVEEVSL is a neoantigen that can be efficiently targeted on AML by &Dgr;NPM1 TCR gene transfer. Immunotherapy targeting &Dgr;NPM1 may therefore contribute to treatment of AML.
Tuberculosis Genetic Epidemiology: A Latin American Perspective

There are an estimated 10 million new cases of tuberculosis worldwide annually, with 282,000 new or relapsed cases each year reported from the Americas. With improvements in genome sequencing technology, it is now possible to study the genetic diversity of tuberculosis with much greater resolution. Although tuberculosis bacteria do not engage in horizontal gene transfer, the genome is far more variable than previously thought. The study of genome-wide variation in tuberculosis has improved our understanding of the evolutionary origins of tuberculosis, the arrival of tuberculosis in Latin America, the genetic determinants of drug resistance, and lineage-specific associations with important clinical phenotypes. This article reviews what is known about the arrival of tuberculosis in Latin America, the genetic diversity of tuberculosis in Latin America, and the genotypic determinants of clinical phenotypes.
Accelerations – a new approach to quantify physical performance decline in male elite soccer?

Abstract The aim of the current study was (1) to investigate whether the number of accelerations is a more precise estimate of performance decline in soccer compared to distances with high-speed running (HSR) and (2) to compare changes in the number of accelerations and HSR distances across playing positions in order to examine whether the match profiles of the physical measures are consistent or demonstrate high interposition variability. The dataset includes domestic home games (N = 34) over three full seasons (2012–2014) for a team in the Norwegian Elite League. The change in the number of accelerations throughout the match demonstrates a more clear pattern compared to the distance covered by HSR. In numbers of accelerations, a systematic and linear decrease can be observed throughout the match, with 34% less accelerations from the first to the last 5-minute period of the game (6.7 vs. 4.4 accelerations). This pattern of results captures the change in the number of accelerations across all positions. HSR distance had more variability during the match. All five positions investigated displayed a similar trend in accelerations and HSR profiles after the peak periods in each half. In contrast to the absolute number of accelerations, there were major positional differences in the mean HSR distance during the match. Our data suggest a more visible performance decline in the number of accelerations from the start to the end of the game, than the decline in the distance covered by HSR distance.
Angiopoietin‐2 as a predictor of acute kidney injury in critically ill patients and association with ARDS

Angiopoietin‐2 (AGPT2) has been proposed as a key mediator of organ dysfunction, mainly in acute respiratory distress syndrome (ARDS). It has also been associated with acute kidney injury (AKI). We aimed to investigate the role of AGPT2 in patients with and without ARDS.
Social Loneliness after Divorce: Time-Dependent Differential Benefits of Personality, Multiple Important Group Memberships, and Self-Continuity

Background: Critical events in the second half of life, such as divorce, pose a significant threat to well-being. Individuals undergoing divorce often experience feelings of social loneliness and may benefit differently from available resources depending on how much time has passed since the event. Personality traits have been found to be related to adaptation, with particularly strong effects immediately after the critical event. Other resources, such as identity-stabilizing mechanisms (i.e., valued social groups and self-continuity), may play a role only later in adaptation. However, little is known about the benefits of these resources and their potentially time-dependent effects on social loneliness when one is overcoming later-life divorce. Objectives: This study investigates the role of psychological (e.g., personality, self-continuity, multiple important group memberships) and social resources (e.g., new partner, having someone to help deal with divorce) for social loneliness in two post-divorce phases, using a married group as the reference, controlling for sociodemographic aspects and health. Methods: A representative sample of 850 divorced (aged 40–79 years) and 869 married individuals (aged 40–78 years) living in Switzerland were compared, using multiple regression analyses. Results: Differential predictive patterns for social loneliness between the two divorced groups and the married group were observed. For the short-term divorced (up to 2 years after divorce), higher extroversion and agreeableness and lower neuroticism were associated with lower levels of loneliness. For the long-term divorced (2–5 years after divorce) and for those who remained married, extroversion was similarly important for loneliness. Additionally, higher levels of self-continuity and multiple group memberships predicted lower loneliness, but the short-term divorced did not benefit from them. Having someone to help overcome the divorce benefited members of both divorced groups. A new partner was related to less loneliness, but only in the long-term divorced group. Conclusions: Our findings demonstrate that the effects of psychological and social resources on social loneliness vary by adaptation phase. Although extroversion is beneficial for all divorced and married individuals, other personality traits play a more decisive role in the initial adaptation phase. Identity-promoting resources (i.e., multiple group memberships, perceived self-continuity) are beneficial only later in the adaptation process. To be successful, professional interventions must be tailored as needed.
Spiritual Pain Is Associated with Decreased Quality of Life in Advanced Cancer Patients in Palliative Care: An Exploratory Study.

Background: Improving quality of life (QOL) is important in cancer palliative care (PC) patients. "Spiritual pain" (SP) is common in this population, but it is unknown how it affects QOL. Objective: To study the associations between SP and QOL in cancer patients in PC. Design: Cross-sectional. Settings/Subjects: Cancer patients assessed at a PC clinic in Puente Alto, Chile, were enrolled in a longitudinal study to characterize patients' end of life. Inclusion criteria included age ≥18, a primary caregiver, not having delirium, and a Karnofsky performance status (KPS) ≤80. Measurements: After consenting patients completed baseline surveys that included demographics, single-item questions to assess SP (0-10), financial distress, spirituality-related variables and questionnaires to assess QOL (0-100), and physical (Global distress score-physical) and psychological distress (Hospital Anxiety and Depression Scale), baseline data analyses to explore associations between SP and QOL were adjusted for potential confounders. Results: Two hundred and eight patients were enrolled: mean age was 64, 50% were female, and 67% had SP. In univariate analysis, SP was significantly associated with lower QOL (coefficient [95% confidence interval]: -1.88 [-2.93 to -0.84], p < 0.001). Lower QOL was also associated with being younger, lower KPS, higher physical distress, having anxiety or depression, and decreased religiosity and religious coping. In the multivariate analysis, QOL remained independently associated with SP (-1.25 [-2.35; to -0.15], p < 0.026), religious coping (11.74 [1.09 to 22.38], p < 0.031), and physical distress (-0.52 [-0.89 to -0.16], p < 0.005). Conclusions: SP is associated with QOL in cancer patients in PC. SP should be regularly assessed to plan for interventions that could impact QOL. More research is needed.
Reflexions sur le déchiffrement des inscriptions cariennes

Les inscriptions cariennes sont connues depuis fort longtemps puisque les premières furent publiées par Lepsius dans la seconde moitié du dix-neuvième siècle. E n 1932, J . Friedrich [3] dans un travail qui reste encore aujourd'hui extrêmement précieux, en collationnait 76, essentiellement des graffiti en provenance d'Egypte, tracés par des légionnaires cariens du temps de Psammétique. Dans les années cinquante, L. Robert [10] et L. Deroy [1] publiaient l'essentiel des inscriptions trouvées en Carie même. Aujourd'hui, le total des inscriptions connues s'élève à près de ISO. Malgré l'abondance de cette documentation, le déchiffrement de ces inscriptions est cependant considéré comme loin d'être acquis.La raison généralement invoquée pour cet insuccès est la brièveté des documents qui ont été découverts: La plupart ne comptent guère plus d'une dizaine de signes et le texte le plus long (D 16), qui contient quelque 230 signes, est malheureusement mutilé. Par ailleurs, il ne comporte aucun de ces «séparateurs de mots» si utiles au déchiffreur. Une deuxième raison, cependant rarement mise en évidence, nous paraît plus importante: Il s'agit de l'hétérogénéité du matériel. Il est assez surprenant que les savants qui se sont occupés du déchiffrement des inscriptions cariennes aient largement négligé ce facteur pourtant fondamental. Certes, des tentatives ont bien eu lieu pour tenter de classer les documents en séries homogènes: Sevoroskin par exemple ([14] p. 72) distingue : 1. les inscriptions sur les objets pharaoniques en provenance de Memphis et Sais, 2. les graffiti d'Abydos, 3. ceux de Thèbes, 4. de Silsilis, 5. d'AbouSimbel, 6. de Wadi-Halfa, 7. les inscriptions de la Carie du Nord, 8. celles de la Carie du Nord-Ouest, 9. de l'Ouest, 10. du Centre, 11. du Sud-Est. Mais cette classification est avant tout géographique et non fondée sur les inscriptions elles-mêmes. Or tout laisse à penser que même les groupes considérés comme homogènes par Sevoroskin se rattachent en fait à deux ou plusieurs systèmes d'écriture différents: Nous prendrons comme exemple les inscriptions d'Abydos (F 1 à F 30) : On relève immédiatement que certains graffiti se r é p è t e n t sous des formes légèrement différentes : Dans le cas des inscriptions 5a, 5 b et 5 c, les différences entre les lettres des inscriptions répétées sont tellement minces qu'elles peuvent être attribuées à de simples différences de graphie: L'alphabet est le même, mais les scribes ont chacun leur manière propre de tracer les lettres.
The Gender Difference in the Association Between Early Onset of Drinking and Problem Drinking Between the U.S. and Japan

ABSTRACT Using comparable survey data from the GENACIS Project, collected from representative samples of people aged 20 to 70 years old in the U.S. (n = 2,598) and Japan (n = 1,734), this study examined, across these two diverse societies, the gender difference in the association between the early onset of drinking and the development of drinking problems. The results of this study suggest that there does not appear to be a cross-national causal relationship between the early onset of drinking and problem drinking because of significant country and gender variations in this association and because there is no association found among Japanese females. As hypothesized, the early onset of drinking predicted problem drinking among males more strongly than among females in both countries.