Miracle-dz/UniFAR-FTUs huggingface dataset:
Stem cell therapy for cardiac disease

Introduction: Cardiovascular disease is the leading cause of mortality throughout the world. Stem cell therapy offers the potential for significantly reducing the burden of this disease. Areas covered: In this review, we broadly discuss cell therapy for cardiac repair. We describe mammalian cardiac regeneration, and discuss animal models of cardiac disease. The effects of various cell therapies on cardiovascular disease are described. Particular attention is given to adult bone-marrow-derived mesenchymal stem cells. Additional cell populations that have been studied are also described. We provide suggestions of where further advances in the field will be made. We anticipate that the reader will gain a comprehensive knowledge of the context of cell therapy for cardiac disease, will be informed of recent advances, and will have an appreciation of the possible future direction of cellular therapeutics for cardiac disease. Expert opinion: There is a sound rationale behind cell therapy for cardiac repair and animal studies have shown promising results. Early clinical trials have demonstrated that cell therapy is safe, with modest therapeutic efficacy. Carefully designed future trials are required if cell therapy is to progress to mainstream therapy.
[Efficacy and safety of the HAA regimen as induction chemotherapy in 236 de novo acute myeloid leukemia].

OBJECTIVE To evaluate the efficacy and safety of the HAA regimen (homoharringtonine, cytarabine and aclarubicin) as induction chemotherapy in de novo acute myeloid leukemia (AML). METHODS The efficacy and safety of 236 de novo AML patients who received the HAA regimen as induction chemotherapy were retrospectively analyzed. The complete remission (CR) rate was assayed. Kaplan-Meier method was used to estimate overall survival (OS) and relapse free survival (RFS), and the differences were compared by Log-rank test. RESULTS The overall CR rate was 78.0%, and 65.7% of the patients attained CR in the first induction cycle. The early death rate was 4.7%. The median followup time was 41(1-161) months. The estimated 5-year OS and 5-year RFS rates were 44.9% and 45.5%, respectively. The CR rates of patients with favorable, intermediate and unfavorable cytogenetics were 92.9%,78.6%and 41.7%, respectively. The 5-year OS of favorable and intermediate group were 61.1% and 45.1%, respectively. The 5- year RFS of favorable and intermediate group were 49.0% and 45.4%, respectively. The median survival time of unfavorable group was only 5 months. The side effects associated with the HAA regimen were tolerable, in which the most common toxicities were myelosuppression and infection. CONCLUSION The HAA regimen is associated with a higher rate of CR and longer survival time and its toxicity could be tolerated.
Evidence of modulation-dependent fading of signal amplitude due to fiber dispersion in radio-over-fiber transmission

Effects of fiber dispersion on Radio-over-Fiber (RoF) transmission of a single-carrier microwave signal employing 16-quadrature amplitude modulation (16-QAM) have been experimentally demonstrated. In addition to the signal fading due to fiber dispersion, another cyclic variation of signal amplitude that depends on the modulation depth has been theoretically predicted in the literature (Reference [2]). To confirm the prediction experimentally, we set up a RoF link transmitting a 16-QAM microwave signal, and observed the change in the constellation map of the QAM signal. The optical signal was prepared by modulating the output of a distributed feedback-laser diode using a lithium-niobate intensity modulator. When the modulation depth was small, the constellation maps after the transmission experienced degradation in their signal-to-noise ratio, but any other significant change was not observed. If we employed a large modulation depth, however, outer symbols in the constellation map moved slightly outwards as the signal propagated down the fiber. If we eliminated harmonic sidebands using an optical filter, the movement of the outer symbols is relaxed compared with the unfiltered case. From these results, we could confirm the prediction in the literature that the movement of the outer symbols was due to the beat between the fundamental and the second-harmonic sidebands, the relative phases between which were shifted due to fiber dispersion.
Parametric Dwarf Spheroidal Tidal Interaction

The time-dependent tidal interaction of the Local Group dwarf spheroidal (dSph) galaxies with the Milky Way (MW) can fundamentally affect their dynamical properties. The model developed here extends earlier numerical descriptions of dSph-MW tidal interactions. We explore the dynamical evolution of dSph systems in circular or elliptical MW orbits in the framework of a parametric oscillator. An analytic model is developed and compared with more general numerical solutions and N-body simulation experiments.
Papillon-Lefèvre Syndrome and Malignant Melanoma

Papillon-Lefèvre syndrome (PLS) is a rare autosomal-recessive genodermatosis characterized by palmoplantar hyperkeratosis and severe early-onset periodontitis. The development of malignant cutaneous neoplasms within the hyperkeratotic lesions of the syndrome is quite rare. Here, we report on a 51-year-old Japanese woman with PLS associated with recurrent malignant melanoma (MM). Mutation analysis of the cathepsin C gene revealed that the proband was homozygous for a missense mutation, c.415G→A, which is predicted to result in the amino acid substitution p.G139R. Including our case, 4 families have been described as having PLS with MM, 3 of which are Japanese, implying a high incidence of melanoma development in Japanese PLS patients. We suggest that hereditary palmoplantar keratoderma (PPK) in Japanese patients might be predisposed to MM. A literature review revealed that in 18 cases of MM-associated PPK, 13 (76%) were Japanese, suggesting a high incidence of MM in Japanese PPK patients. This tendency might be attributable to the high frequency of acral lentiginous melanoma in Japanese subjects, in contrast to a lower frequency of this subtype in Caucasians.
The Information-Processing Paradigm: A Valuable Framework for Clinical Child and Adolescent Psychology

Provides an introduction to the special section on information-processing (I-P) factors in child and adolescent psychopathology. First, we describe the I-P paradigm and summarize its central tenets, presenting examples of past research that illustrate the heuristic value of the paradigm. Next, we discuss the potential benefits of the I-P paradigm for the field of clinical child and adolescent psychology. Finally, we present an overview of the articles in the special section.
Histological and histochemical investigation of human alveolar socket healing in undisturbed extraction wounds.

A histological and histochemical study of undisturbed alveolar socket healing was undertaken, utilizing postextraction biopsies from normal human tissues at two to three day intervals over a period of 50 days. Generally, the sequence in the healing o f an alveolar socket after exodontia is as follows : (1 ) clot forma­ tion; (2 ) replacement of blood clot by granulation tissue (seventh d a y); (3 ) replacement of granulation tissue by connective tissue (twentieth d a y); (4 ) appearance of osteoid at the base of the socket (seventh day) and filling of at least two thirds of socket fundus by trabeculae (thirty-eighth day), and (5 ) evidence of epithelization (fourth day).
Health literacy in patients referred for transplant: do patients have the capacity to understand?

Adequate levels of health literacy are needed for transplant recipients to be able to understand and comply with medical recommendations. However, little is known about health literacy among transplant candidates. Therefore, the purpose of this study was to examine the levels of health literacy and cognitive functioning among patients being evaluated for various types of transplantation. There were 398 patients who completed a required psychological evaluation prior to being listed for transplant. This included a screen for cognitive impairment and limited reading and math ability. The prevalence of limited reading ability was 27.5%, limited math ability was 42.8%, and 30.7% had probable cognitive impairment. Rates of limited reading and math ability and cognitive impairment varied for each type of end‐stage disease. Limited reading ability was related to poorer cognitive functioning. Those with a higher likelihood of limited reading ability included blacks and males. Those more likely to have cognitive impairment included blacks and patients who are older. Results from this study suggest that patients should be regularly screened for health literacy and cognitive impairment. Once patients with difficulties are identified, recommendations can be provided to these patients at a level that they are able to understand.
Influvac, a trivalent inactivated subunit influenza vaccine

Importance of the field: Influenza represents a major sanitary and socio-economic burden and vaccination is universally considered the most effective strategy for preventing the disease and its complications. Traditional influenza vaccines have been on the market since the late 1940s, with million of doses administered annually worldwide, and demonstrated a substantial efficacy and safety. Areas covered in this review: The trivalent inactivated subunit vaccine has been available for more than 25 years and has been studied in healthy children, adults and the elderly and in people affected by underlying chronic medical conditions. We describe vaccine technology focusing on subunit vaccine production procedures and mode of action and provide updated information on efficacy and safety available data. What the reader will gain: A review of efficacy and safety data in healthy subjects and in high risk populations from major sponsor- and investigator-driven studies. Take home message: The vaccine showed a good immunogenicity and a favorable safety profile in all target groups. In the panorama of actually available influenza vaccines, trivalent inactivated subunit vaccine represents a well-established tool for preventing flu and the associated complications.
Mare problems in the last month of pregnancy.

Medical problems in the last month of pregnancy may have devastating effects on the foal or both the mare and the foal. This paper will review the most common medical complaints in the last month of pregnancy in the mare. A general overview of the evaluation of the colicky mare in advanced pregnancy is provided as a guideline for differentiation between genital and nongenital causes of colic. Diagnosis and management of specific genital causes of colic as well as some specific condition related to the reproductive tracts are discussed in detail. Authors’ address: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, e-mail: tibary@vetmed.wsu. edu. *Corresponding and presenting author. © 2012 AAEP.
Evaluation of extracorporeal circulation effects on gallstone formation

1 Cirurgião do Aparelho Digestivo Mestre em Gastroenterologia Cirúrgica-EPM-UNIFESP. 2Professor Assistente da Disciplina de Gastroenterologia Cirúrgica Departamento de Cirurgia-EPM-UNIFESP. 3Professor Assistente da Disciplina de Gasroenterologia Cirúrgica Departamento de Cirurgia e Coordenador do Programa de PósGraduação em Gastroenterologia Cirúrgica da EPM-UNIFESP. 4 Cirurgião Cardiovascular (Chefe da Disciplina de Cirurgia Cardiovascular Escola Paulista de Medicina -UNIFESP).
No association between novelty seeking and the type 4 dopamine receptor gene (DRD4) in two New Zealand samples.

OBJECTIVE In 1986 and 1987, Cloninger postulated the existence of the heritable behavioral trait of novelty seeking and its putative underpinnings in the dopaminergic systems of the ventral midbrain. Two widely reported studies found significant associations between novelty seeking and the type 4 dopamine receptor gene (DRD4), although a more recent study did not. The authors' objective was to investigate this association in two New Zealand samples. METHOD The authors studied two nonoverlapping samples: subjects in a depression treatment trial (N = 86) and subjects from 14 pedigrees dense with alcoholism (N = 181). DRD4 genotyping was based on a standard protocol. RESULTS Novelty seeking and DRD4 were not statistically associated. CONCLUSIONS In these samples, there was no suggestion that the DRD4 polymorphism contributed to individual differences in the behavioral trait of novelty seeking.
Single Sensor Techniques for Sleep Apnea Diagnosis Using Deep Learning

A large number of obstructive sleep apnea (OSA) cases are under-diagnosed due unavailability, inconvenience or expense of sleep labs. Hence, an automated detection by applying computational techniques to multivariate signals has already become a well-researched subject. However, the best-known techniques that use various features have not achieved the gold standard of polysomnography (PSG) tests. In this paper, we substantiate the medical conjecture that OSA directly impacts body parameters such as Instantaneous Heart Rate (IHR) and blood oxygen saturation (SpO2). We then use a deep learning technique called LSTM-RNN (long short-term memory recurrent neural networks) to experimentally prove that OSA severity detection can be solely based on either IHR or SpO2 signals, which can be easily, obtained using off-the-shelf non-intrusive wearable single sensors. The results obtained from LSTM-RNN model shows an area under curve (AUC) of 0.98 associated with very high accuracy on a dataset of more than 16,000 apnea non-apnea minutes. These results have encouraged our collaborating doctors to further come up with a diagnostic protocol that is based on LSTM-RNN, SpO2, and IHR, thereby increasing the chances of larger adoption among medical community.
Changes in short‐term memory processes in patients with multiple sclerosis

In this study we compared the performance of 39 multiple sclerosis (MS) patients with 28 age‐, sex‐ and education‐matched controls on both the Mini‐Mental State Examination, a global cognitive assessment tool, and the Sternberg Short‐Term memory scanning task, a standardized test of short‐term memory (STM) processes. While the STM span of our MS patients did not differ from that of our controls, STM scanning time of the MS group was reliably slower than that of the controls and a significat correlation was observed between STM scanning time and duration but not severity of illness. Our results suggest that processing stages other than the manipulation of data within the STM buffer are also affected by MS.
Methylenetetrahydrofolate reductase polymorphism, plasma homocysteine and age

Elevated fasting levels of total homocysteine are now accepted as an independent risk factor for the development of arteriosclerotic vascular diseases. A polymorphism in the gene encoding methylenetetrahydrofolate reductase (MTHFR), caused by the C677T point mutation, leads to increased thermolability of the enzyme, with reduced enzyme activity. We studied the frequency of this mutation in different groups of the Swiss adult population.
For the Mouths of Babes: Nutrition Literacy Outreach to a Child Care Center

Childhood obesity is at crisis levels in the United States. Risk factors for obesity can begin as early as infancy. Approximately 12 million children up to five years of age spend about 22.5 hours per week in child care centers where they receive a significant portion of their daily nutrition. Child care center personnel may not know how to select nutritious meal and snack choices. A health sciences librarian, a child care center director, and a dietitian designed an outreach program on nutrition that helped child care center teachers gain increased nutrition literacy. The teachers indicated that they gained increased personal understanding of formerly confusing nutrition issues (e.g., how to read a nutrition label and what defines a whole grain). Teachers were also able to identify aspects of web sites linked from MedlinePlus that indicated the sites served as reliable sources of health information.
Solid-State Rhodamine 6G Microcavity Laser

In this letter, we demonstrate lasing from Rhodamine 6G in a microcavity organic vertical cavity surface emitting laser (VCSEL) in solid state. We adopted an original approach to forming thin films of Rhodamine 6G doped into a poly(methyl methacrylate) (PMMA) host matrix and to integrating them in a dielectric microcavity architecture. We dissolved the materials in dimethylformamide and then spin coated the gain layer onto a planar dielectric mirror in an anhydrous environment to prevent premature precipitation of the PMMA. The second dielectric mirror was positively curved and was positioned on top of the gain layer to form a VCSEL with a tunable cavity resonance and a quality factor exceeding Q = 1500. We optically excited the device through one of the cavity resonances using femtosecond pulses and observed lasing above a threshold of 17±3 μJ/cm2 of absorbed energy. The lasing emission followed the polarization of the pump and narrowed from 0.85 to 0.05 nm.
ABIOTIC FORMATION OF CARBOXYLIC ACIDS (RCOOH) IN INTERSTELLAR AND SOLAR SYSTEM MODEL ICES

The present laboratory study simulated the abiotic formation of carboxylic acids (RCOOH) in interstellar and solar system model ices of carbon dioxide (CO2)–hydrocarbon mix CnH2n+2 (n = 1–6). The pristine model ices were irradiated at 10 K under contamination-free, ultrahigh vacuum conditions with energetic electrons generated in the track of galactic cosmic-ray particles. The chemical processing of the ices was monitored by a Fourier transform infrared spectrometer and a quadrupole mass spectrometer during the irradiation phase and subsequent warm-up phases on line and in situ in order to extract qualitative (carriers) and quantitative (rate constants and yields) information on the newly synthesized species. Carboxylic acids were identified to be the main carrier, together with carbon monoxide (CO) and a trace of formyl (HCO) and hydroxycarbonyl (HOCO) radicals at 10 K. The upper limit of acid column density at 10 K was estimated as much as (1.2 ± 0.1) × 1017 molecules cm−2 at doses of 17 ± 2 eV molecule−1, or the yield of 39% ± 4% from the initial column density of carbon dioxide. The temporal column density profiles of the products were then numerically fit using two independent kinetic schemes of reaction mechanisms. Finally, we transfer this laboratory simulation to star-forming regions of the interstellar medium, wherein cosmic-ray-induced processing of icy grains at temperatures as low as 10 K could contribute to the current level of chemical complexity as evidenced in astronomical observations and in extracts of carbonaceous meteorites.
Lost in translation: on lactate, hypotension, sepsis-induced tissue hypoperfusion, quantitative resuscitation and Surviving Sepsis Campaign bundles.

Critical Care Medicine www.ccmjournal. org 705 delirium duration and short-term mortality: A systematic review and meta-analysis. Crit Care Med 2014; 42:1442–1454 7. Mehta S, Cook D, Devlin JW, et al; for the SLEAP Investigators and the Canadian Critical Care Trials Group: Prevalence, Risk Factors, and Outcomes of Delirium in Mechanically Ventilated Adults. Crit Care Med 2015; 43:557–566 8. Mehta S, Burry L, Cook D, et al; SLEAP Investigators; Canadian Critical Care Trials Group: Daily sedation interruption in mechanically ventilated critically ill patients cared for with a sedation protocol: A randomized controlled trial. JAMA 2012; 308:1985–1992 9. Ferrell BA, Girard TD: Sedative choice: A critical decision. Am J Respir Crit Care Med 2014; 189:1295–1297 10. Pandharipande PP, Pun BT, Herr DL, et al: Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: The MENDS randomized controlled trial. JAMA 2007; 298:2644–2653 11. Ouimet S, Kavanagh BP, Gottfried SB, et al: Incidence, risk factors and consequences of ICU delirium. Intensive Care Med 2007; 33:66–73 12. Patel SB, Poston JT, Pohlman A, et al: Rapidly reversible, sedationrelated delirium versus persistent delirium in the intensive care unit. Am J Respir Crit Care Med 2014; 189:658–665 13. Strauss R, Wehler M, Mehler K, et al: Thrombocytopenia in patients in the medical intensive care unit: Bleeding prevalence, transfusion requirements, and outcome. Crit Care Med 2002; 30:1765–1771
Probing mouse brain microstructure using oscillating gradient diffusion MRI

High resolution diffusion tensor images of the mouse brain were acquired using the pulsed gradient spin echo sequence and the oscillating gradient spin echo sequence. The oscillating gradient spin echo tensor images demonstrated frequency‐dependent changes in diffusion measurements, including apparent diffusion coefficient and fractional anisotropy, in major brain structures. Maps of the rate of change in apparent diffusion coefficient with oscillating gradient frequency revealed novel tissue contrast in the mouse hippocampus, cerebellum, and cerebral cortex. The observed frequency‐dependent contrasts resembled neuronal soma‐specific Nissl staining and nuclei‐specific 4′,6‐diamidino‐2‐phenylindole (DAPI) staining in the mouse brain, which suggests that the contrasts might be related to key features of cytoarchitecture in the brain. In the mouse cuprizone model, oscillating gradient spin echo‐based diffusion MRI revealed significantly higher frequency‐dependence of perpendicular diffusivity (λ⊥) in the demyelinated caudal corpus callosum at 4 weeks after cuprizone treatment when compared with control mice and mice at 6 weeks after cuprizone treatment. The elevated frequency‐dependence of λ⊥ coincided with the infiltration of activated microglia/macrophages and disruption of axons during acute demyelination in the caudal corpus callosum. The results demonstrate the potential of oscillating gradient spin echo‐based diffusion MRI for providing tissue contrasts complimentary to conventional pulsed gradient spin echo‐based diffusion MRI. Magn Reson Med 67:98–109, 2012. © 2011 Wiley Periodicals, Inc.
A Modified Pipeline FFT Architecture

This paper presents a modified pipeline single-path delay feedback (SDF) fast Fourier transform (FFT) architecture. The canonic signed digit (CSD) representation is used to design the function of complex multiplier, which is the main function block in the FFT processor. The processor of a 16-bit 16-point pipeline FFT is realized on the Xilinx Virtex-4 FPGAs. The achieved maximum clock frequency is 196.8 MHz, utilizing 310 out of 49152 slices and 241 out of 98304 look-up tables. Another 16-bit 64-point pipeline FFT processor is also realized. The achieved maximum clock frequency is 111.2 MHz, utilizing 1303 out of 49152 slices and 2065 out of 98304 look-up tables. Comparing with the conventional complex multiplier, the derived results show the proposed design has improved efficiency on Virtex-4.
Satellite sputtering in Saturn ’ smagnetosphere

The heavy ion plasma and energetic particles continuously sputter the surfaces of the icy satellites embedded in the inner Saturnian magnetosphere. We evaluate satellite sputtering and compare the resulting H2O source distribution with the source distribution expected for the OH cloud recently observed by Hubble Space Telescope. At each satellite we combine, for the 2rst time, the data from the Plasma Science (PLS) and Low Energy Charged-Particle (LECP) instruments from Voyager 1 and 2, unifying them into a single plasma distribution function. Based on the calculated satellite sources, we conclude that sputtering of the satellite surfaces cannot produce the observed OH cloud and that a large additional source in the inner magnetosphere is needed to fully explain the HST observations. c © 2001 Elsevier Science Ltd. All rights reserved.