Clinical utility of the clinical dementia rating scale for Parkinson’s disease dementia

The purpose of this study is to explore validity of the Clinical Dementia Rating Scale (CDR) in measuring dementia among individuals with Parkinson’s disease. The CDR was created for use in patients with Alzheimer’s disease and, to date, there are no published studies specifically examining if the CDR is appropriate for patients with PD. The data were obtained from the National Alzheimer’s Coordinating Center database (The NACC database is funded by National Institute on Aging grant number U01 AG016976). There were 490 subjects (mean/SD: Age = 72.11/9.20; education = 16.09/6.07; 73.3% male) diagnosed with dementia (n= 151), mild cognitive impairment (n= 186), or normal cognition (n = 153) by a physician. Inclusion criteria were a diagnosis of Parkinson’s disease. Exclusion criteria were possible or probable Alzheimer’s disease or other confounding conditions. Sensitivity, specificity, positive predictive value and negative predictive value were calculated for the previously published CDR Global Score as well as the Sum of Boxes cutoff scores for each of the 3 diagnostic categories. Finally, new cutoff scores were calculated using sensitivity and specificity values derived from the Receiver Operating Characteristic curves. The results indicate the CDR is a useful tool in identifying dementia in patients with Parkinson’s disease when the cutoff scores are adjusted. Degree Type Dissertation Rights Terms of use for work posted in CommonKnowledge. Comments Library Use: LIH This dissertation is available at CommonKnowledge: http://commons.pacificu.edu/spp/1070 Copyright and terms of use If you have downloaded this document directly from the web or from CommonKnowledge, see the “Rights” section on the previous page for the terms of use. If you have received this document through an interlibrary loan/document delivery service, the following terms of use apply: Copyright in this work is held by the author(s). You may download or print any portion of this document for personal use only, or for any use that is allowed by fair use (Title 17, §107 U.S.C.). Except for personal or fair use, you or your borrowing library may not reproduce, remix, republish, post, transmit, or distribute this document, or any portion thereof, without the permission of the copyright owner. [Note: If this document is licensed under a Creative Commons license (see “Rights” on the previous page) which allows broader usage rights, your use is governed by the terms of that license. ] Inquiries regarding further use of these materials should be addressed to: CommonKnowledge Rights, Pacific University Library, 2043 College Way, Forest Grove, OR 97116, (503) 352-7209. Email inquiries may be directed to:. copyright@pacificu.edu This dissertation is available at CommonKnowledge: http://commons.pacificu.edu/spp/1070 CLINICAL UTILITY OF THE CLINICAL DEMENTIA RATING SCALE FOR PARKINSON’S DISEASE DEMENTIA A DISSERTATION SUBMITTED TO THE FACULTY OF SCHOOL OF PROFESSIONAL PSYCHOLOGY PACIFIC UNIVERSITY HILLSBORO, OREGON BY KATHRYN A. WYMAN-CHICK IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PSYCHOLOGY JULY 26, 2013 APPROVED BY THE COMMITTEE: BJ Scott, Psy.D Jane M. Tram, Ph.D. PROFESSOR AND DEAN: Christiane Brems, Ph.D. ABPP UTILITY OF CDR FOR PARKINSON’S DISEASE DEMENTIA ii TABLE OF CONTENTS Page ABSTRACT iv ACKNOWLEDGMENTS v LIST OF TABLES vi LIST OF FIGURES vi