Miracle-dz/UniFAR-FTUs huggingface dataset:
GENETIC BASIS FOR ALTERNATIVE REPRODUCTIVE TACTICS IN THE PYGMY SWORDTAIL, XIPHOPHORUS NIGRENSIS

Differences in adult male size and age at sexual maturity in the Río Coy (Mexico) population of Xiphophorus nigrensis (Pisces; Poeciliidae) are controlled by genetic variation at a Y‐linked locus. Four genetic size‐classes have been identified. The mating behavior of the males of the three largest size‐classes consists exclusively of an elaborate courtship display, whereas that of the genetically small males ranges from display to a sneak‐chase attempt at copulation. In the presence of large males, small males switch to the sneak‐chase behavior. Females prefer the display of large males. In mating‐competition experiments (two females with one large male and one small male), the large males are dominant and deny the small males access to females. From 20 such experiments, 601 large‐male and 200 small‐male progeny were obtained, indicating that the switch to sneak‐chase behavior by small males is not particularly effective in overcoming the large‐male advantage. By using the largest males of the genetically smallest size class and the smallest males of the genetically next‐larger size‐class, size was kept constant, whereas genotype was varied. When these males were tested in competition with genetically large males, only the males of the genetically smallest size class showed sneak‐chase behavior. These observations suggest that the difference in mating behavior is not an indirect developmental effect of size but, rather, is under direct genetic control.
Rotational atherectomy in the drug-eluting stent era: a single-center experience.

BACKGROUND In heavily calcified lesions, rotational atherectomy (RA) improves procedural success and facilitates stent deployment. Reports on RA in the drug-eluting stent (DES) era are limited. The objective of this study was to determine the presenting characteristics, procedural and in-hospital clinical outcomes of patients who underwent RA at our institution in the DES era. METHODS Consecutive cases involving RA between January 1, 2004 and December 31, 2009 at a private, tertiary referral hospital were reviewed retrospectively. RESULTS A total of 158 patients (236 lesions) who underwent RA are described, including 112 patients (158 lesions) with subsequent DES implantation, 19 patients (28 lesions) with bare-metal stent (BMS) implantation, and 27 patients (50 lesions) with no stent. RA was utilized to modify heavily calcified plaque (84%), as bail-out therapy (16%), to preserve the patency of sidebranches (25%) and as debulking therapy for chronic total occlusion (13 lesions) and in-stent restenosis (7 lesions). DES were not placed in 46 patients (23%) due to reference vessel diameter < 2.25 or > 3.75 mm, inability to deliver DES, or desire to avert clopidogrel therapy. Angiographic and procedural success rates were significantly higher in the DES and BMS groups compared with the no stent group (angiographic success: 99.1% for DES versus 95% for BMS versus 63% for no stent; p < 0.05; procedural success: 96.4% for DES versus 95% for BMS versus 63% for no stent; p < 0.05). CONCLUSION In the DES era, RA remains utilized primarily to modify heavily calcified plaque. In unadjusted analysis, procedural success appears high with subsequent stent placement (DES or BMS) versus RA alone. However, 1 in 4 are not candidates for stent placement, and the lower procedural success rate in this population should be considered prior to embarking on RA.
Altruistic Kidney Donation to a Stranger: Psychosocial and Functional Outcomes at Two US Transplant Centers

Background. The number of living kidney donors with no preexisting relationship to the recipient has increased sharply. This study compared the psychosocial and functional outcomes of these altruistic donors to a stranger (ADs) with donors with a longstanding relationship with the recipient (traditional donors [TDs]). Methods. ADs (n=39) and TDs (n=52), who were similar on age, sex, and year of donation, were recruited from two transplant programs in the United States. Participants completed validated measures of psychosocial and functional outcomes a median of 5 years after donation (range, 1–12 years). Results. ADs and TDs did not differ significantly in the total number of donation motives. Both were motivated by a desire to help, the benefits to the recipient outweighing the risks to the donor, a sense of moral duty, and imagining oneself in the position of the recipient. Psychological benefits were endorsed equally by both types of donors, although TDs reported higher Quid Pro Quo scores relative to ADs (P=0.04). ADs and TDs did not differ significantly on any of the Short Form-36, Version 2 scales (P values ranged from 0.19 to 0.85). Few donors (3 ADs and 1 TD) regretted their donation decision. Conclusion. Overall, findings indicate that carefully screened ADs experience psychosocial and functional outcomes comparable with those of TDs and should not be systematically excluded from the opportunity to donate.
The importance of early identification and intervention for children with or at risk for autism spectrum disorders

Abstract There has been a dramatic rise in the number of children being diagnosed with autism spectrum disorders (ASD), which has led to increased attention paid to assessment and intervention issues. This manuscript agrees with Camarata (2014) that the evidence base for early assessment and intervention should be expanded. However, it disagrees with Warren et al.'s (2011) assumption that there are not empirically validated early interventions. Reliable diagnosis has been documented during infancy and toddlerhood, and evidence suggests that the earlier the onset of intervention, the greater likelihood of an improved developmental trajectory. It is argued that early intervention is more cost and time efficient than a “wait and see” approach. With regard to published studies, the large amount of heterogeneity in the ASD population supports the use of rigorous single case experimental design research. It is an error to limit empirical evidence for treatments to only randomized clinical trials, which have the weakness of masking individual differences. Single case experimental designs examine the effects of intervention beyond typical maturation by allowing for clear estimations of developmental trajectories prior to the onset of intervention, followed by evaluation of the impact of the intervention. This commentary discusses the short- and long-term benefits of early diagnosis and intervention.
Dipole-glass behavior of lightly doped KTa1-xNbxO3.

High-resolution x-ray diffraction measurements have been performed between 10 and 300 K on several single crystals of KTa 1-x Nb x O 3 with x≤0.157. Contrary to the published phase diagram, no deviation from cubic symmetry is seen for x≤0.060. Instead, a low-temperature minimum in the cubic unit cell volume is observed at a temperature T min which increases monotonically for 0.012≤x≤0.060. Data for x=0.157, however, are consistent with the previously established sequence of structural transitions from cubic to tetragonal to orthorhombic to rhombohedral symmetries
Incompetent and dilated ovarian veins: a common CT finding in asymptomatic parous women.

OBJECTIVE Incompetent and dilated ovarian veins have been reported in association with pelvic congestion syndrome. We postulate that incompetent and dilated ovarian veins are often an incidental CT finding, with a low diagnostic value. To verify our hypothesis, we studied the frequency of incompetent and dilated ovarian veins seen on CT in asymptomatic women. MATERIALS AND METHODS We retrospectively analyzed helical CT scans and medical records of 34 consecutive female renal donors between 18 and 46 years old (mean age, 33 years). An incompetent and dilated ovarian vein was defined as a contrast-filled vein measuring 7 mm or greater, seen during the arterial phase of helical CT. RESULTS Incompetent and dilated ovarian veins were found in 16 (47%) of 34 asymptomatic women. All 16 women had left ovarian vein involvement; six (37.5%) had bilateral involvement. The mean diameters for the left and right (incompetent and dilated) ovarian veins were 9.1 mm and 8.8 mm, respectively (range, 7-12 mm). Of 16 women with incompetent and dilated ovarian veins, 15 (94%) were parous. Of 18 women with normal ovarian veins, nine (50%) were parous. Overall, incompetent and dilated ovarian veins were found in 15 (63%) of 24 parous women, and in one (10%) of 10 nonparous women (p < 0.05). CONCLUSION Incompetent and dilated ovarian veins are frequently seen on CT in asymptomatic parous women. As an isolated finding, it is unlikely to be associated with pelvic congestion syndrome.
Monetary versus Macroprudential Policies Causal Impacts of Interest Rates and Credit Controls in the Era of the UK Radcliffe Report

We have entered a world of conjoined monetary and macroprudential policies. But can they function smoothly in tandem, and with what effects? Since this policy cocktail has not been seen for decades, the empirical evidence is almost non-existent. We can only fix this shortcoming in a historical laboratory. The Radcliffe Report (1959), notoriously sceptical about the efficacy of monetary policy, embodied views which led the United Kingdom to a three-decade experiment of using credit controls alongside conventional changes in the central bank interest rate. These non-price tools are similar to policies now being considered or used by macroprudential policymakers. We describe these tools, document how they were used by the authorities, and craft a new, largely hand-collected dataset to help estimate their effects. We develop a novel identification strategy, which we term Factor-Augmented Local Projection (FALP), to investigate the subtly different impacts of both monetary and macroprudential policies. Monetary policy acted on output and inflation broadly in line with consensus views today, but credit controls had markedly different effects and acted primarily to modulate bank lending.
The politics of place: Understanding meaning, common ground, and political difference on the Rocky Mountain Front : Sense of place

A major challenge of forest policy and management is effectively understanding different people's viewpoints on natural resource use and conservation, and how those viewpoints contribute to conflict and conflict resolution. In response to this challenge, the concept of place is gaining currency in natural resource research. The study of place promises an integrative approach to understanding people's relationships with particular areas. Realiz- ing the potential of place research to inform forest policy and management means conceptu- alizing place as an arena of shared and contested meanings. A politics of place is attentive to different and potentially conflicting meanings, and how senses of place may be connected to larger political struggles. This study examines people's images, values, and interests with respect to the Rocky Mountain Front in Montana. In this case study, discourse about place- names provided a window into the politics of place. Results illustrate the ways in which place meanings are connected to people's ideas about property, conservation, and governance. Knowledge of the politics of place can inform forest policy and management and contribute to a more sophisticated understanding of natural resource conflict and the potential effective- ness of decision-making processes. FOR. SCI. 49(6):855-866.
Characteristics of intestinal dendritic cells in inflammatory bowel diseases.

BACKGROUND & AIMS Dendritic cells (DCs) recognize and respond to microbial structures using pattern recognition receptors, including Toll-like receptors (TLRs). In the intestine, DCs are pivotal in tolerance induction and direct the differentiation of T cells. We aimed to identify changes in intestinal DCs that may underlie the dysregulated immune response to enteric bacteria that occurs in patients with inflammatory bowel disease (IBD). METHODS DCs were identified in freshly isolated lamina propria mononuclear cells by multicolor flow cytometry in patients with IBD and controls. Expression of TLR2, TLR4, and the activation/maturation marker CD40 was assessed by cell surface labeling. Production of cytokines (interleukin [IL]-12, IL-6, and IL-10) was assessed in the absence of exogenous stimulation by intracellular staining of permeabilized cells. RESULTS In healthy controls, few intestinal DCs expressed TLR2 or TLR4, in contrast to blood DCs. DC expression of both TLRs was significantly enhanced in Crohn's disease and ulcerative colitis. DCs from inflamed tissue of patients with Crohn's disease expressed significantly higher levels of the maturation/activation marker CD40. Elevated levels of CD40 on DCs were decreased after treating patients with anti-tumor necrosis factor alpha. In Crohn's disease, but not ulcerative colitis, more colonic DCs produced IL-12 and IL-6. The number of IL-10-producing DCs did not differ significantly between patients with IBD and controls. CONCLUSIONS In IBD, DCs are activated, their expression of microbial recognition receptors is up-regulated, and more DCs produce pathologically relevant cytokines. Intestinal DCs are likely to be key initiators or perpetuators of the inflammatory response that characterizes IBD.
Hardy weinberg expectations in canine breeds: implications for genetic studies.

Hardy-Weinberg equilibrium (HWE) is a useful indicator of genotype frequencies within a population and whether they are based on a valid definition of alleles and a randomly mating sample. HWE assumes a stable population of adequate size without selective pressures and is used in human genetic studies as a guide to data quality by comparing observed genotype frequencies to those expected within a population. The calculation of genetic associations in case-control studies assume that the population is "in HWE. " Canine breed populations deviate away from many of the criteria for HWE, and if genetic markers are not in HWE, conventional statistical analysis cannot be performed. To date, little attention has been paid as to whether genetic markers in dog breeds are distributed in compliance to HWE. In this study, 109 single-nucleotide polymorphisms (SNPs) were genotyped from 13 genes in a cohort of 894 dogs encompassing 33 breeds. Analysis of the entire cohort of dogs revealed a significant deviation away from HWE for all SNPs tested (P < 0.00001); analysis of the cohort stratified by breed and subbreed indicated that the majority of the markers complied with HWE expectation. This suggests that canine case-control association studies will be valid if performed within defined breeds.
Mycobacterium bovis Strain Bacillus Calmette-Guérin-Induced Liver Granulomas Contain a Diverse TCR Repertoire, but a Monoclonal T Cell Population Is Sufficient for Protective Granuloma Formation1

Granuloma formation is a form of delayed-type hypersensitivity requiring CD4+ T cells. Granulomas control the growth and dissemination of pathogens, preventing host inflammation from harming surrounding tissues. Using a murine model of Mycobacterium bovis strain bacillus Calmette-Guérin (BCG) infection we studied the extent of T cell heterogeneity present in liver granulomas. We demonstrate that the TCR repertoire of granuloma-infiltrating T cells is very diverse even at the single-granuloma level, suggesting that before granuloma closure, a large number of different T cells are recruited to the lesion. At the same time, the TCR repertoire is selected, because AND TCR transgenic T cells (Vα11/Vβ3 anti-pigeon cytochrome c) are preferentially excluded from granulomas of BCG-infected AND mice, and cells expressing secondary endemic Vβ-chains are enriched among AND cells homing to granulomas. Next, we addressed whether TCR heterogeneity is required for effective granuloma formation. We infected 5CC7/recombinase-activating gene 2−/− mice with recombinant BCG that express pigeon cytochrome c peptide in a mycobacterial 19-kDa bacterial surface lipoprotein. A CD4+ T cell with a single specificity in the absence of CD8+ T cells is sufficient to form granulomas and adequately control bacteria. Our study shows that expanded monoclonal T cell populations can be protective in mycobacterial infection.
Path Generation Using  ${\mbi \eta}^4$-Splines for a Truck and Trailer Vehicle

Generation of high-quality drive paths is a significant issue for automated wheeled vehicles. To achieve this aim for a truck and trailer vehicle, the paper proposes the use of a parameterized curve primitive, the η4-spline. Using this spline, generation and shaping of smooth feasible paths is made possible as well as the transfer between arbitrary dynamic configurations of the articulated vehicle. The η4-spline is a ninth-order polynomial curve that can interpolate given Cartesian points with associated arbitrary unit tangent vector, curvature, and first and second derivatives of curvature. It depends on a set of eight (eta) parameters that can be freely chosen to modify the path shape without changing the interpolations conditions at the path endpoints. Completeness, minimality, and symmetry of the η4-spline are established. An example on a parking maneuver of the articulated vehicle is presented and the pertinent optimal path planning is also discussed.
The 2015 Catalan Election: The Independence Bid at the Polls

Abstract This paper examines the context, campaign and main determinants of how Catalans voted in the 2015 regional election. The elections were exceptional because the incumbent and the remaining Catalan nationalist parties framed the contest as a de facto referendum on secession. In this paper we scrutinise whether attitudes towards independence affected vote choice and whether they eclipsed other traditional significant vote-driving factors such as the state of the economy or government performance. Results show that, although the independence issue became a major determinant of vote choice, the elections did not become a pure plebiscite on secession, since voters also used their vote to hold the regional government accountable for its past performance.
Detection of Fluconazole-Resistant Isolates of Candida glabrata by Using an Agar Screen Assay

ABSTRACT The ability of a fluconazole-containing agar screen assay to accurately detect isolates of Candida glabrata resistant to the azole antifungal agent fluconazole was evaluated on a collection of 100 clinical isolates of this organism. Results were correlated with the MIC of fluconazole for these isolates and compared with the results of a previously published disk diffusion-based fluconazole resistance screening test. Agar screen assay results were in categorical agreement with MIC-based determinations for 97% (97/100) of the isolates tested. This correlation was higher than that obtained with the disk diffusion technique, which categorized only 87% (87/100) of isolates correctly, and suggests that the agar screening approach can effectively expedite fluconazole susceptibility testing of C. glabrata isolates.
Cross-Border Resolution of Global Banks: Bail in Under Single Point of Entry Versus Multiple Points of Entry

The design of resolution regimes for global groups has been the central theme since the global financial crisis. No model rationalized the optimal design of bail-in regimes and their welfare consequences. We do so in a model with strategically optimizing authorities and banks. We model three regimes: cooperative-SPE (Single Point of Entry), uncooperative-SPE and MPE (Multiple Points of Entry). Welfare losses in each regime depend on the degree of banks' liabilities home bias. SPE cooperative generally minimizes losses since authorities internalize cross-country spillovers, unless groups are highly decentralized. High capital requirements by acting as discipline devise reduce losses and blur the difference between regimes. SPE has however unintended consequences: under cooperation it increases financial re-trenchment in previously segmented markets (by the same token it stimulates integration in well integrated markets), under non-cooperation subsidiarization emerges as an endogenous outcome.
Prediction Markets for Machine Learning: Equilibrium Behaviour through Sequential Markets

Prediction markets which trade on contracts representing unknown future outcomes are designed specifically to aggregate expert predictions via the market price. While there are some existing machine learning interpretations for the market price and connections to Bayesian updating under the equilibrium analysis of such markets, there is less of an understanding of what the instantaneous price in sequentially traded markets means. In this thesis I show that the prices generated in sequentially traded prediction markets are stochastic approximations to the price given by an equilibrium analysis. This is done by showing that the equilibrium price is a solution to a stochastic optimisation problem which is solved by stochastic mirror descent (SMD) by a class of sequential pricing mechanisms. This connection leads to proposing a scheme called “mini-trading” which introduces a parameter related to the learning rate in SMD. I prove several properties of this scheme and show that it can improve the stability of prices in sequentially traded prediction markets. Also I analyse two popular trading models (namely the Maximum Expected Utility model and the Risk-measure model) in respect to an assumption on the class of traders I required to interpret sequential markets as SMD. I derive a sufficient condition for when the Maximum Expected Utility traders satisfy this assumption, but show that risk-measure based traders naturally satisfy this assumption for the type of markets I consider. Then I show that the “regret” of mini-trading markets (with respect to equilibrium markets) depend on the mini-trade parameter. Finally I attempt to compare the wealth updates of traders in sequential markets to the wealth updates in equilibrium markets, since this would help to extend the interpretation of equilibrium markets as performing Bayesian updates to sequential markets. For this I present preliminary results.
Bone loss in the oral cavity

Bone loss in the oral cavity may occur due to many causes, including infection, systemic or local alterations in the host response, or multifactorial causes. The purpose of this article is to review our present understanding of the major causes of oral bone loss in adults, with special emphasis on two major oral diseases: periodontitis and residual ridge resorption. Periodontitis is characterized by resorption of the alveolar bone as well as loss of the soft tissue attachment to the tooth. Progressive periodontitis will result in continued alveolar bone loss and may result in tooth mobility, abscesses, and ultimately tooth loss. Although the reported prevalence may vary according to the epidemiologic study design, the 1985 National Survey of Oral Health of United States Adults indicated that 94% of female senior citizens examined demonstrated at least one site with at least 2 mm loss of attachment. Resorption of alveolar bone that occurs following tooth extraction is termed residual ridge resorption. In many cases, the denture will loosen because of the inability of the resorbed ridge to stabilize the prosthesis. In the most severe cases, the denture may impinge on the exposed mandibular nerve, resulting in pain or total inability to tolerate the prostheses. Although clear statistics on the prevalence of residual ridge resorption are not available, this boss loss may result in the need for new dentures to replace ill‐fitting prostheses.