Miracle-dz/UniFAR-FTUs huggingface dataset:
Biochemical analysis of pleural and ascitic fluid: effect of sample timing on interpretation of results

Background: Modified Light's criteria are widely used to categorize pleural fluids as either exudates or transudates. Similarly, the serum-ascites albumin gradient (SAAG) is used in the differential diagnosis of ascites, particularly with reference to the prediction of portal hypertension. Fluid and serum samples are required for both of these to be applied. The effect of the time interval between fluid and serum samples on the interpretation of results has not been studied. Methods: We examined the effect of sample timing on (a) the application of modified Light's criteria, and (b) the categorization of SAAG as wide (≥11 g/L) or narrow (<11 g/L). Specifically, we compared the use of a 'routine' serum sample, i.e. one that was not formally paired by the requesting clinician with the fluid sample, with serum samples collected within 2 h of the fluid sample. Results: Of 77 pleural fluids included for analysis, 45/47 were categorized as exudates, and 32/30 as transudates, using near-simultaneous/routine serum samples respectively. Discrepant categorization was observed in two cases (P=0.74). Of 109 ascitic fluids, SAAG was ≥11 g/L in 100/95 cases, and <11 g/L in 9/14, using near-simultaneous/routine serum samples respectively. Discrepant categorization was observed in five cases (P=0.27). Conclusions: With reference to categorizing pleural and ascitic fluids as described above under (a) and (b), in most cases the use of routine serum samples does not alter the fluid categorization compared with the use of serum samples collected within 2 h.
Integrated model shows that atmospheric brown clouds and greenhouse gases have reduced rice harvests in India

Previous studies have found that atmospheric brown clouds partially offset the warming effects of greenhouse gases. This finding suggests a tradeoff between the impacts of reducing emissions of aerosols and greenhouse gases. Results from a statistical model of historical rice harvests in India, coupled with regional climate scenarios from a parallel climate model, indicate that joint reductions in brown clouds and greenhouse gases would in fact have complementary, positive impacts on harvests. The results also imply that adverse climate changes due to brown clouds and greenhouse gases contributed to the slowdown in harvest growth that occurred during the past two decades.
Good schools or good students? Evidence on school effects from universal random assignment of students to high schools

How much do schools differ in their effectiveness? Answering this question has been complicated by the selection of heterogeneous students into schools, which has made it difficult to distinguish between the influence of school inputs, student selection and peer effects. We exploit universal random assignment of students to high schools in certain areas of South Korea to provide clean estimates of the influence of school inputs. We find statistically significant differences across schools in the effects they have on scores in college entrance exams. However, school effects explain only 0.5% of the variation in learning outcomes in areas where students are randomized to schools. These results suggest that school inputs play a limited role in explaining variation in learning outcomes.
Epiphyte Biodiversity in the Coffee Agricultural Matrix: Canopy Stratification and Distance from Forest Fragments

Abstract: Quality of the agricultural matrix profoundly affects biodiversity and dispersal in agricultural areas. Vegetatively complex coffee agroecosystems maintain species richness at larger distances from the forest. Epiphytes colonize canopy trees and provide resources for birds and insects and thus effects of agricultural production on epiphytes may affect other species. We compared diversity, composition, and vertical stratification of epiphytes in a forest fragment and in two coffee farms differing in management intensity in southern Mexico. We also examined spatial distribution of epiphytes with respect to the forest fragment to examine quality of the two agricultural matrix types for epiphyte conservation. We sampled vascular epiphytes in a forest fragment, a shade polyculture farm, and a shade monoculture farm at 100 m, 200 m, and 400 m from the forest. Epiphyte and orchid richness was greater in the forest than in the monoculture but richness was similar in the forest and polyculture farm. Epiphyte species composition differed with habitat type, but not with distance from the forest. In the forest, epiphytes were distributed throughout tree canopies, but in the farms, epiphytes were primarily found on trunks and larger branches. Epiphyte richness and species similarity to forest species declined with distance from the forest fragment in the monoculture, but richness and similarity to forest species did not decline with distance from forest in the polyculture. This suggests polyculture coffee has greater conservation value. In contrast, monoculture coffee is likely a sink habitat for epiphytes dispersing from forests into coffee. Coffee farms differ from forests in terms of the habitat they provide and species composition, thus protecting forest fragments is essential for epiphyte conservation. Nonetheless, in agricultural landscapes, vegetatively complex coffee farms may contribute to conservation of epiphytes more than other agricultural land uses.
The Role of Contingent Capital Structure in Signaling and Information Disclosure

This paper advocates two novel advantages of contingent convertible securities in capital structure in (1) signaling, and (2) information disclosure. First, in order to signal his type, the good banker should be punished for poor performance and rewarded otherwise. Since the banker knows better about events occurring in the near future (i.e., the interim states) than final cash flows to be realized in the distant future, the former are better performance indicators, thereby providing contingent securities with additional signaling power. Nevertheless, this advantage needs to be supported by a positive cost of misreporting interim states. Second, even if misreporting is costless, contingent capital structure still has an advantage over non-contingent capital in its ability to mitigate ex-post information asymmetries, since it has more degrees of freedom in setting payoffs to fine-tune the issuer's truth-telling incentives. This paper thus sheds some new light on the design of CoCos and the regulation of contingent capital.
Emerging role for colorectal cancer screening in Asian countries.

BACKGROUND AND AIM Colorectal cancer (CRC) is one of the leading causes of cancer related mortality globally. Though Asia has traditionally been considered a relatively low incidence area for colorectal cancer, the incidence is reportedly increasing. The Asia Pacific Working Group for Colorectal Cancer has recommended screening of individuals at average risk starting from 50 years of age. Based on these recommendations we conducted a pilot study to assess the need and feasibility of a colorectal cancer screening program in the state of Qatar. METHODS AND RESULTS We screened 1385 individuals by fecal immunochemical testing for occult blood, at the primary health center level and positive cases were referred for colonoscopy. Among those who tested positive for fecal occult blood, we picked up five patients with cancers and seven with neoplastic polyps. CONCLUSION Our results compare with the yield of screening programs in western countries thus suggesting an emerging role for colorectal cancer screening in Asian countries.
The roles of networks among innovators in regional innovation: comparative analysis between China and South Korea

ABSTRACT In port cities, terminal operating companies (TOCs) are considered as regional innovators. Numerous studies have attempted to find their characteristics; however, relatively few studies have been devoted to exploring softer factors such as human resources or networks with other innovators such as universities and government agencies, not hard factors such as available cargo and cargo processing ability. Therefore, this study aims to examine both hard and softer factors perceived by 232 South Korean and Chinese regional innovators, TOC; the empirical relationships among these characteristics, networks among regional innovators such as industry–university–government networks (I–U–G networks), and regional innovation, the moderating role of the I–U–G networks in improving the regional innovation, and the comparative analysis between Chinese and Korean cases. To achieve these research purposes, an empirical model was employed. As a result, excepting government support policy, remaining variables significantly affected regional innovation. Further, the I–U–G networks moderated the relationships between determinants and regional innovation. These results imply that establishing effective I–U–G networks was pivotal in achieving regional innovation. In addition, this study provides a contribution, that there are national differences due to each other’s different environmental characteristics, by comparing characteristics between Korean and Chinese regional innovators with different characteristics.
Venous Outflow Simplified by the Cephalic Vein Loop

Long vein loops derived from the major upper extremity superficial veins may be accessed for venous outflow in difficult cases of trunk, arm, or head and neck free tissue transfers when local possibilities have proved inadequate. This technique may negate the need for an interposition vein graft to a deep venous system, reduce the number of microanastomoses required, and allow an easy end-to-end anastomosis to a large caliber vessel. The cephalic vein loop would be the most versatile option because a great length can be achieved with minimal dissection.
Enhancement of Anthrax Lethal Toxin Cytotoxicity: a Subset of Monoclonal Antibodies against Protective Antigen Increases Lethal Toxin-Mediated Killing of Murine Macrophages

ABSTRACT We investigated the ability of using monoclonal antibodies (MAbs) against anthrax protective antigen (PA), an anthrax exotoxin component, to modulate exotoxin cytotoxic activity on target macrophage cell lines. Anthrax PA plays a critical role in the pathogenesis of Bacillus anthracis infection. PA is the cell-binding component of the two anthrax exotoxins: lethal toxin (LeTx) and edema toxin. Several MAbs that bind the PA component of LeTx are known to neutralize LeTx-mediated killing of target macrophages. Here we describe for the first time an overlooked population of anti-PA MAbs that, in contrast, function to increase the potency of LeTx against murine macrophage cell lines. The results support a possible mechanism of enhancement: binding of MAb to PA on the macrophage cell surface stabilizes the PA by interaction of MAb with macrophage Fcγ receptors. This results in an increase in the amount of PA bound to the cell surface, which in turn leads to an enhancement in cell killing, most likely due to increased internalization of LF. Blocking of PA-receptor binding eliminates enhancement by MAb, demonstrating the importance of this step for the observed enhancement. The additional significance of these results is that, at least in mice, immunization with PA appears to elicit a poly-clonal response that has a significant prevalence of MAbs that enhance LeTx-mediated killing in macrophages.
Protective effects of Bushen Tiansui decoction on hippocampal synapses in a rat model of Alzheimer's disease

Bushen Tiansui decoction is composed of six traditional Chinese medicines: Herba Epimedii, Radix Polygoni multiflori, Plastrum testudinis, Fossilia Ossis Mastodi, Radix Polygalae, and Rhizoma Acorus tatarinowii. Because Bushen Tiansui decoction is effective against amyloid beta (Aβ) toxicity, we hypothesized that it would reduce hippocampal synaptic damage and improve cognitive function in Alzheimer's disease. To test this hypothesis, we used a previously established animal model of Alzheimer's disease, that is, microinjection of aggregated Aβ25–35 into the bilateral brain ventricles of Sprague-Dawley rats. We found that long-term (28 days) oral administration of Bushen Tiansui decoction (0.563, 1.688, and 3.375 g/mL; 4 mL/day) prevented synaptic loss in the hippocampus and increased the expression levels of synaptic proteins, including postsynaptic density protein 95, the N-methyl-D-aspartate receptor 2B subunit, and Shank1. These results suggested that Bushen Tiansui decoction can protect synapses by maintaining the expression of these synaptic proteins. Bushen Tiansui decoction also ameliorated measures reflecting spatial learning and memory deficits that were observed in the Morris water maze (i.e., increased the number of platform crossings and the amount of time spent in the target quadrant and decreased escape latency) following intraventricular injections of aggregated Aβ25–35 compared with those measures in untreated Aβ25–35-injected rats. Overall, these results provided evidence that further studies on the prevention and treatment of dementia with this traditional Chinese medicine are warranted.
Restorative Retelling for Violent Death: An Investigation of Treatment Effectiveness, Influencing Factors, and Durability

Many adults who have lost a loved one to violent death suffer from depression, posttraumatic stress disorder (PTSD), and complicated grief. Limited research has examined structured group interventions for violent death survivors or characteristics (e.g., types of loss, quality and type of relationship with the deceased) that may impact response to intervention. This records review of 91 survivors examined the effectiveness of Restorative Retelling (RR), a brief structured group intervention for violent loss survivors. Participants completed depression, PTSD, and complicated grief measures at pre- and post-treatment and at 1-year follow-up for a subset of participants. Findings revealed statistically significant changes in depression and PTSD symptoms (Cohen's d values ranged from .33–.46) at post-treatment, with significant changes observed across all domains at 1-year follow-up. Treatment response appeared to be influenced by high distress, gender, and relationship with the deceased. Results imply a large-scale randomized control trial to determine treatment efficacy.
Exploring Students’ Perspectives on the Development of Post-Secondary Educational Aspirations

EXPLORING STUDENTS’ PERSPECTIVES ON THE DEVELOPMENT OF POSTSECONDARY EDUCATIONAL ASPIRATIONS Venus Bali Advisory Committee: University of Guelph, 2017 Dr. Olga Sutherland Dr. Tricia van Rhijn This study was focused on Canadian undergraduate students’ perspectives of how they became aspired to pursue higher education. Participants were recruited from undergraduate classes at a university in southwestern Ontario. Seventy-one participants took part in the study and completed an online survey. Narratives from participants were qualitatively analyzed using thematic analysis (Braun & Clarke, 2006). Six different themes were generated: natural progression, societal and parental expectations, family influence, career opportunities, role models, and emancipation. Directions for future research and implications are discussed.
Dead Cat Bounce - Demand Reversal Following the Bursting of a Bubble

This is the first paper to theoretically analyze the temporary reversal of the downward trend in financial assets, also known as dead cat bounce or bear market rally. We show that preferences according to cumulative prospect theory lead an investor to take ex- cessive risk and unprofitable positions in order to recover an initial loss in a declining market. The loss driven behavior results in premature re-entering into the market. We show that heterogeneous investors enter at the same time despite differences in the refer- ence point, wealth and initial loss. The resulting shift in aggregate demand can explain the sudden but temporary reversal common in declining financial markets.
Specific Targeting of the F13L Protein by St-246 Affects Orthopoxvirus Production Differently

Background ST-246 is a potent anti-orthopoxviral molecule targeting the F13L protein of vaccinia virus, which is involved in the wrapping of viruses. The discrepancy in sensitivities of several orthopoxviruses to ST-246 has raised questions about potential differences in their replicative cycles and/or the presence of another drug target. Methods Density gradients were used to evaluate the differences between the viral cycles of vaccinia, cow-pox and camelpox viruses. Also, to investigate if ST-246 inhibits a single target, we compared its activity to that of small interfering RNAs designed to silence the F13L gene (siF13Ls). Results We showed that the spread of vaccinia virus involved both intracellular and extracellular enveloped viruses, whereas both cowpox and camelpox viruses seemed to propagate via non-enveloped intracellular forms and cell-associated viral particles. Although ST-246 exerted a clear antiviral activity by interfering with the egress of the virus from infected cells, we observed that cowpox and camelpox viruses, in contrast to vaccinia virus, could be directed towards a lytic cycle under ST-246 treatment. We specifically knocked down the F13L transcripts of vaccinia and camelpox viruses by >85%, reduced virus progeny by 90% and showed that siF13Ls affect camelpox and vaccinia virus propagation differently. Flow cytometry data validated that ST-246 interfered with the activity of the F13L protein, whereas siF13Ls silenced the F13L gene. Conclusions Our observations support that vaccinia, cow-pox and camelpox viruses exhibit different levels of sensitivity to ST-246 because of dissimilarities between their ways of propagation, and provide a better understanding of the mode of action of ST-246.
Vaccination of a Melanoma Patient with Mature Dendritic Cells Pulsed with MAGE-3 Peptides Triggers the Activity of Nonvaccine Anti-Tumor Cells1

We previously characterized the CTL response of a melanoma patient who experienced tumor regression following vaccination with an ALVAC virus coding for a MAGE-A3 Ag. Whereas anti-vaccine CTL were rare in the blood and inside metastases of this patient, anti-tumor CTL recognizing other tumor Ags, mainly MAGE-C2, were 100 times more frequent in the blood and considerably enriched in metastases following vaccination. In this study we report the analysis of the CTL response of a second melanoma patient who showed a mixed tumor response after vaccination with dendritic cells pulsed with two MAGE-A3 antigenic peptides presented, respectively, by HLA-A1 and HLA-DP4. Anti-MAGE-3.A1 CD8 and anti-MAGE-3.DP4 CD4 T cells became detectable in the blood after vaccination at a frequency of ∼10−5 among the CD8 or CD4 T cells, respectively, and they were slightly enriched in slowly progressing metastases. Additional anti-tumor CTL were present in the blood at a frequency of 2 × 10−4 among the CD8 T cells and, among these, an anti-MAGE-C2 CTL clone was detected only following vaccination and was enriched by >1,000-fold in metastases relative to the blood. The striking similarity of these results with our previous observations further supports the hypothesis that the induction of a few anti-vaccine T cells may prime or restimulate additional anti-tumor T cell clones that are mainly responsible for the tumor regression.
Altered impulse control in alcohol dependence: neural measures of stop signal performance.

BACKGROUND Altered impulse control has been implicated in the shaping of habitual alcohol use and eventual alcohol dependence. We sought to identify the neural correlates of altered impulse control in 24 abstinent patients with alcohol dependence (PAD), as compared to 24 demographics matched healthy control subjects (HC). In particular, we examined the processes of risk taking and cognitive control as the neural endophenotypes of alcohol dependence. METHODS To this end, functional magnetic resonance imaging (fMRI) was conducted during a stop signal task (SST), in which a procedure was used to elicit errors in the participants. The paradigm allowed trial-by-trial evaluation of response inhibition, error processing, and post-error behavioral adjustment. Furthermore, by imposing on the subjects to be both fast and accurate, the SST also introduced a distinct element of risk, which participants may or may not avert during the task. Brain imaging data were analyzed with Statistical Parametric Mapping in covariance analyses accounting for group disparity in general performance. RESULTS The results showed that, compared to HC, PAD demonstrated longer go trial reaction time (RT) and higher stop success rate (SS%). HC and PAD were indistinguishable in stop signal reaction time (SSRT) and post-error slowing (PES). In a covariance analysis accounting for go trial RT and SS%, HC showed greater activity in the left dorsolateral prefrontal cortex than PAD, when subjects with short and long SSRT were contrasted. By comparing PAD and HC directly during stop errors (SE), as contrasted with SS, we observed greater activity in PAD in bilateral visual and frontal cortices. Compared to HC, PAD showed less activation of the right dorsolateral prefrontal cortex during PES, an index of post-error behavioral adjustment. Furthermore, PAD who showed higher alcohol urge at the time of the fMRI were particularly impaired in dorsolateral prefrontal activation, as compared to those with lower alcohol urge. Finally, compared to HC subjects, PAD showed less activity in cortical and subcortical structures including putamen, insula, and amygdala during risk-taking decisions in the SST. CONCLUSION These preliminary results provided evidence for altered neural processing during impulse control in PAD. These findings may provide a useful neural signature in the evaluation of treatment outcomes and development of novel pharmacotherapy for alcohol dependence.
Onychoscopy: A practical guide

Onychoscopy refers to the examination of the nail unit using a dermoscope. Since the advent of dermoscopy, attempts have been made to use it for the diagnosis of nail disorders, most commonly pigmented lesions. As of now, onychoscopy has carved out a distinct niche for itself in the diagnostic work up of nail disorders. The nail is capable of mounting only a limited number of reaction patterns to the large number of disorders affecting it. Therefore, simple visual inspection may not be helpful in diagnosing many conditions reliably. Even a nail biopsy may not give a definitive answer every time. Onychoscopy is thus a valuable aid not only in enhancing visible nail features but also in revealing cryptic features of diagnostic value. This review aims to summarize the current level of knowledge about onychoscopic features of various diseases of the nail unit. It also aims to offer practical tips on how to conduct onychoscopy. For the purpose of review, a PubMed search about the indications and results of onychoscopy was done using the keywords “onychoscopy,” “nail fold capillaroscopy,” “dermoscopy nail” and “dermatoscopy nail. ” All the articles were retrieved and classified into case reports, reviews and clinical studies. The final data was then analyzed and presented in a narrative fashion.