Miracle-dz/UniFAR-FTUs huggingface dataset:
Classification accuracy of nonword repetition when used with preschool-age Spanish-speaking children.

PURPOSE The purpose of the present study was to (a) describe and compare the nonword repetition (NWR) performance of preschool-age Spanish-speaking children (3- to 5-year-olds) with and without language impairment (LI) across 2 scoring approaches and (b) to contrast the classification accuracy of a Spanish NWR task when item-level and percentage of phonemes correct (PPC) scoring methods are applied. METHOD Forty-four Spanish-speaking children participated. Twenty-one children had LI and 23 had typically developing (TD) language. Children were administered a Spanish NWR task and a standardized Spanish language measure. RESULTS A developmental pattern in NWR performance was observed, and the children with LI had NWR scores that were significantly lower than those of the TD children. Whereas item-level scoring of NWR items indicated acceptable levels of sensitivity and specificity and suggested positive and negative likelihood ratios, PPC scoring of NWR items resulted in less than desirable levels of sensitivity and adequate specificity. CONCLUSION Item-level scoring of 3- to 5-syllable Spanish NWR items may be useful as part of an assessment battery for preschool-age Spanish-speaking children.
Root trunk concavities as a risk factor for regenerative procedures of class II furcation lesions in humans.

BACKGROUND The purpose of this study was to evaluate the influence of root trunk concavities on guided tissue regeneration in humans and to determine if a modification in membrane design could improve the results. METHODS Ten patients who provided 10 pairs of similar Class II furcation defects were recruited for the study. Each defect was randomly assigned to treatment with either a normal expanded polytetrafluoroethylene (ePTFE) membrane (NM) or a modified ePTFE membrane (MM). The MM were made by removing the collar from an NM, cutting it into 2 mm segments, and suturing each of the segments to the collar of each MM. Following basic therapy, baseline clinical measurements were recorded using an acrylic stent, including probing depth (PD) and clinical attachment level (CAL). Full flaps were elevated, the defects were carefully debrided, and the root surfaces were decontaminated with manual and ultrasonic instruments. Hard tissue measurements were performed during surgery to determine vertical (VD) and horizontal defect (HD) depths. Then, NM and MM were sutured to their corresponding tooth and the flaps sutured. Membranes remained in position for 6 weeks. After 1 year, all sites were re-entered and soft and hard tissue measurements were recorded. RESULTS After 1 year, there were no statistically significant differences (Mann-Whitney test) between NM and MM groups in percentages of PD reduction (P= 0.27), CAL change (P= 0.26), or VD resolution (P = 0.13). However, percentage of HD resolution (NM: 24.3+/-11.8; MM: 44.8+/-16.0) was significantly different between groups (P= 0.008). CONCLUSIONS The modified membranes resulted in greater horizontal resolution of Class II furcation defects. The collars of the membranes should be modified to improve results when root trunk concavities are present.
The MisR Response Regulator Is Necessary for Intrinsic Cationic Antimicrobial Peptide and Aminoglycoside Resistance in Neisseria gonorrhoeae

ABSTRACT During infection, the sexually transmitted pathogen Neisseria gonorrhoeae (the gonococcus) encounters numerous host-derived antimicrobials, including cationic antimicrobial peptides (CAMPs) produced by epithelial and phagocytic cells. CAMPs have both direct and indirect killing mechanisms and help link the innate and adaptive immune responses during infection. Gonococcal CAMP resistance is likely important for avoidance of host nonoxidative killing systems expressed by polymorphonuclear granulocytes (e.g., neutrophils) and intracellular survival. Previously studied gonococcal CAMP resistance mechanisms include modification of lipid A with phosphoethanolamine by LptA and export of CAMPs by the MtrCDE efflux pump. In the related pathogen Neisseria meningitidis, a two-component regulatory system (2CRS) termed MisR-MisS has been shown to contribute to the capacity of the meningococcus to resist CAMP killing. We report that the gonococcal MisR response regulator but not the MisS sensor kinase is involved in constitutive and inducible CAMP resistance and is also required for intrinsic low-level resistance to aminoglycosides. The 4- to 8-fold increased susceptibility of misR-deficient gonococci to CAMPs and aminoglycosides was independent of phosphoethanolamine decoration of lipid A and the levels of the MtrCDE efflux pump and seemed to correlate with a general increase in membrane permeability. Transcriptional profiling and biochemical studies confirmed that expression of lptA and mtrCDE was not impacted by the loss of MisR. However, several genes encoding proteins involved in membrane integrity and redox control gave evidence of being MisR regulated. We propose that MisR modulates the levels of gonococcal susceptibility to antimicrobials by influencing the expression of genes involved in determining membrane integrity.
Experimental ammonia poisoning in cattle fed extruded or prilled urea: clinical findings Intoxicação experimental por amônia em bovinos que rece- beram uréia extrusada ou granulada: achados clínicos

Twelve yearling Girolando, rumen-fistulated steers never fed with urea before, were distributed randomly in 2 groups of 6 animals each. Both groups were administered intraruminally a single dose (0.5 g/kg BW) of extruded (G1) or prilled (G2) urea to induce ammonia poisoning. The clinical picture was followed for the next 240 min. Besides the classic signs the present study found 3 new additional sign: dehydration, hypothermia and ingurgitated episcleral veins. Convulsion, considered the definite sign, was seen in 5 out of 6 animals from both groups. One steer (G1) had only fasciculation, while another (G2) developed typical clinical signs, but not convulsion, and recovered spontaneously without treatment. The appearance of clinical signs such as muscle tremors, sternal recumbency and convulsive episode occurred at similar times in both groups, but when analyzed altogether they took place later in G1 (p < 0.04). The 1 st sign to show up was fasciculation, followed by apathy, hyperaesthesia, pushing against obstacles, muscle tremor, rumen stasis, incoordination, sternal and then lateral recumbency, mild or severe dehydration, and convulsion. Higher heart rate was detected at the convulsive episodes. After the convulsions, 4 animals from each group had mild hypothermia. One steer from G2 fell down in coma and died suddenly before the beginning of the treatment. Although the extruded urea postponed the clinical picture, the signs were as severe as exhibited by cattle administered prilled urea. Both forms of urea offered at high dose can be harmful to cattle never fed urea. Key-words: Urea. Ammonia poisoning. Clinical picture. Cattle.
The effect of hysterectomy on urinary symptoms and residual bladder volume

This was a prospective, clinical study to evaluate the effect of abdominal and vaginal hysterectomy for benign indications on urinary symptoms and residual bladder volume. One hundred and seven women undergoing hysterectomy for benign conditions were included in the study that took place in a district general hospital between April 1998 and January 2000. Urinary symptoms such as stress incontinence of urine, urgency, frequency, nocturia, sensation of incomplete voiding and voiding difficulties were considered. A questionnaire was filled out and the residual bladder volume measured with a 'Bard' bladder scanner on three occasions--before the operation, postoperative days 3 or 4 and at the 6-week postoperative visit. Statistical analysis involved using a generalised estimating equation and significance assessed at the 5% level. Each woman acted as her own control. There was no evidence of changes in nocturia and voiding difficulties after surgery. All other symptoms and residual bladder volumes decreased significantly postoperatively. The type of hysterectomy did not have an effect.
Association of the variants and haplotypes in the DOCK7, PCSK9 and GALNT2 genes and the risk of hyperlipidaemia

Little is known about the association between the single nucleotide polymorphisms (SNPs) and haplotypes of the dedicator of cytokinesis 7 (DOCK7), pro‐protein convertase subtilisin/kexin type 9 (PCSK9) and polypeptide N‐acetylgalactosaminyltransferase 2 (GALNT2) and serum lipid traits in the Chinese populations. This study was to determine the association between nine SNPs in the three genes and their haplotypes and hypercholesterolaemia (HCH)/hypertriglyceridaemia (HTG), and to identify the possible gene–gene interactions among these SNPs. Genotyping was performed in 733 HCH and 540 HTG participants. The haplotype of C‐C‐G‐C‐T‐G‐C‐C‐G [in the order of DOCK7 rs1168013 (G>C), rs10889332 (C>T); PCSK9 rs615563 (G>A), rs7552841 (C>T), rs11206517 (T>G); and GALNT2 rs1997947 (G>A), rs2760537 (C>T), rs4846913 (C>A) and rs11122316 (G>A) SNPs] was associated with increased risk of HCH and HTG. The haplotypes of C‐C‐G‐C‐T‐G‐C‐C‐A and G‐C‐G‐T‐T‐G‐T‐C‐G were associated with a reduced risk of HCH and HTG. The haplotypes of G‐C‐G‐C‐T‐G‐C‐C‐A and G‐C‐G‐C‐T‐G‐T‐C‐G were associated with increased risk of HCH. The haplotypes of C‐T‐G‐C‐T‐G‐C‐C‐G, G‐C‐A‐C‐T‐G‐C‐C‐G and G‐C‐G‐C‐T‐G‐C‐C‐A were associated with an increased risk of HTG. The haplotypes of G‐C‐G‐C‐T‐G‐T‐C‐A and G‐C‐G‐T‐T‐G‐T‐C‐G were associated with a reduced risk of HTG. In addition, possible inter‐locus interactions among the DOCK7, PCSK9 and GALNT2 SNPs were also noted. However, further functional studies of these genes are still required to clarify which SNPs are functional and how these genes actually affect the serum lipid levels.
Meta-Analysis of Electroacupuncture in Cardiac Anesthesia and Intensive Care

Background: Acupuncture treatment has been employed in China for over 2500 years and it is used worldwide as analgesia in acute and chronic pain. Acupuncture is also used in general anesthesia (GA). The aim of this systematic review and meta-analysis was to assess the efficacy of electroacupuncture (EA) in addition to GA in patients undergoing cardiac surgery. Methods: We searched 3 databases (Pubmed, Cochrane Library, and Web of Science—from 1965 until January 31, 2017) for randomized controlled trials (RCTs) including patients undergoing cardiac surgery and receiving GA alone or GA + EA. As primary outcomes, we investigated the association between GA + EA approach and the dosage of intraoperative anesthetic drugs administered, the duration of mechanical ventilation (MV), the postoperative dose of vasoactive drugs, the length of intensive care unit (ICU) and hospital stay, and the levels of troponin I and cytokines. Results: The initial search yielded 477 citations, but only 7 prospective RCTs enrolling a total of 321 patients were included. The use of GA + EA reduced the dosage of intraoperative anesthetic drugs (P < .05), leading to shorter MV time (P < .01) and ICU stay (P < .05) as well as reduced postoperative dose of vasoactive drugs (P < .001). In addition, significantly lower levels of troponin I (P < .01) and tumor necrosis factor α (P < .01) were observed. Conclusion: The complementary use of EA for open-heart surgery reduces the duration of MV and ICU stay, blunts the inflammatory response, and might have protective effects on the heart. Our findings stimulate future RCT to provide definitive recommendations.
Drug Pharmacology: Pharmacodynamics (Smith,

1. Epilogue 2. Methods 2.1. Drug Pharmacology: Pharmacodynamics & Pharmacokinetics 2.2. The Mouse Restraint 2.3. Method Improvement 2.3.1. Standardization 2.3.2. Confounding Variables of Previous Studies 2.4. Additional Issues 2.4.1. Dark Adaptation 2.4.2. Role of Iris Pigmentation 2.4. 3. Melanin Binding Inhibition 2.5. Pupillary Measurements & Mouse Size 2.5. 1. Figure: Pupillary Measurements & Mouse Size 2.5. 2. Normal/Control Pupillary Measurements & Mouse Size 2.6. Technique 2.7. Images 3. Statistical Analysis 3.1. Sample Size 3.2. Measurement Reliability 3.3. Repeated Measures 4. Graphs 4.1. Tropicamide Experiment 4.2. Pilocarpine Experiment 5. Additional References
Robust Estimates of Location and Dispersion for High-Dimensional Datasets

The computing times of high-breakdown point estimates of multivariate location and scatter increase rapidly with the number of variables, which makes them impractical for high-dimensional datasets, such as those used in data mining. We propose an estimator of location and scatter based on a modified version of the Gnanadesikan–Kettenring robust covariance estimate. We compare its behavior with that of the Stahel–Donoho (SD) and Rousseeuw and Van Driessen's fast MCD (FMCD) estimates. In simulations with contaminated multivariate normal data, our estimate is almost as good as SD and clearly better than FMCD. It is much faster than both, especially for large dimension. We give examples with real data with dimensions between 5 and 93, in which the proposed estimate is as good as or better than SD and FMCD at detecting outliers and other structures, with much shorter computing times.
Development of decompensated dilated cardiomyopathy is associated with decreased gene expression and activity of the milrinone-sensitive cAMP phosphodiesterase PDE3A.

BACKGROUND Phosphodiesterase III (PDE3) inhibitors are inotropic agents used to treat congestive heart failure (CHF) and are less effective in patients with severe CHF. Little is known about relative changes in PDE3 activity or gene expression during the evolution of cardiomyopathy. METHODS AND RESULTS In the present study, we evaluated temporal changes in PDE3A gene expression before and after pacing-induced CHF in nine mongrel dogs. Three weeks of left ventricular (LV) pacing produced LV end-diastolic pressures of 15+/-1.7 mm Hg, whereas overt CHF at 4 to 5 weeks was associated with LV end-diastolic pressures of 24+/-1.7 mm Hg; prepacing values were 6.6+/-0.6 mm Hg. Total RNA isolated from LV tissues was analyzed on Northern blots; 10 unpaced normal hearts served as tissue controls. Signals for PDE3A mRNAs (7, 8, and 10 kb) or PDE4D (7.6 kb) were normalized against glyceraldehyde-3-phosphate dehydrogenase (GAPDH) or ribosomal 18S RNA. Before the onset of CHF, PDE3A/GAPDH ratios were not different between the control and 3-week paced groups. In contrast, all PDE3A/GAPDH ratios were selectively reduced by 52%, and PDE3A/18S was reduced by 70% (P<.05) in CHF; PDE4D/GAPDH (or 18S) was unchanged. LV tissues from four control and four CHF dogs were also processed to isolate cytosolic and microsomal membrane protein for cAMP PDE3 activity assays. CHF was associated with a significant 54% reduction (P<.05) in microsomal but not cytosolic PDE3 activity. CONCLUSIONS Selective downregulation of PDE3A may account in part for the ineffectiveness of milrinone in the treatment of severe CHF.
Nonlinear Statistical Models

Univariate Nonlinear Regression. Univariate Nonlinear Regression: Special Situations. A Unified Asymptotic Theory for Nonlinear Models with Regression Structure. Univariate Nonlinear Regression: Asymptotic Theory. Multivariate Nonlinear Regression. Nonlinear Simultaneous Equations Models. A Unified Asymptotic Theory for Dynamic Nonlinear Models. References. Index.
Quality of care information for consumers on the Internet.

The purpose of this study was to assess the readability of quality of care information for consumers available on the Internet. Ten Internet resources for consumers, found at three major Web sites, were analyzed for readability. The scores ranged from a low of 6th grade level for information in the document "Quick Checks for Quality: Choosing Quality Health Care" to a high of 12th grade level for "Helping You Choose a Quality Ambulatory Care Organization. " The overall mean reading demands of four of the documents were higher than the 8th grade level recommended for the general public. Six of the documents were at this level or below, placing them at an appropriate reading level for most consumers to understand the information.
A Systemic Review of Patients Appearing to Dental Professionals with Trigeminal Neuralgia Arising From Intracranial Tumours

A several number of patients seeking dentists with trigeminal neuralgia will have intracranial tumors as the primary cause. Before the right diagnosis is made, these patients may undergo unnecessary dental involvements. This is because there are difficulties of diagnosis as the symptoms sometimes lead to misdiagnosis. A search of the literature was done to find case reports of this incidence. Cases is to be analysed for common characteristics or presenting features that may assist dentists in recognizing patients with intracranial tumors.
Prediction Probabilities From Foreshocks

When any earthquake occurs, the possibility that it might be a foreshock increases the probability that a larger earthquake will occur nearby within the next few days. Clearly, the probability of a very large earthquake ought to be higher if the candidate foreshock were on or near a fault capable of producing that very large mainshock, especially if the fault is towards the end of its seismic cycle. We derive an expression for the probability of a major earthquake characteristic to a particular fault segment, given the occurrence of a potential foreshock near the fault. To evaluate this expression, we need: (1) the rate of background seismic activity in the area, (2) the long-term probability of a large earthquake on the fault, and (3) the rate at which foreshocks precede large earthquakes, as a function of time, magnitude, and spatial location. For this last function we assume the average properties of foreshocks to moderate earthquakes in California: (1) the rate of mainshock occurrence after foreshocks decays roughly as t^(−1), so that most foreshocks are within three days of their mainshock, (2) foreshocks and mainshocks occur within 10 km of each other, and (3) the fraction of mainshocks with foreshocks increases linearly as the magnitude threshold for foreshocks decreases, with 50% of the mainshocks having foreshocks with magnitudes within three units of the mainshock magnitude (within three days). We apply our results to the San Andreas, Hayward, San Jacinto, and Imperial faults, using the probabilities of large earthquakes from the report of the Working Group on California Earthquake Probabilities (1988). The magnitude of candidate event required to produce a 1% probability of a large earthquake on the San Andreas fault within three days ranges from a high of 5.3 for the segment in San Gorgonio Pass to a low of 3.6 for the Carrizo Plain.
Dielectrophoretic force-driven thermal convection in annular geometry

The thermal convection driven by the dielectrophoretic force is investigated in annular geometry under microgravity conditions. A radial temperature gradient and a radial alternating electric field are imposed on a dielectric fluid that fills the gap of two concentric infinite-length cylinders. The resulting dielectric force is regarded as thermal buoyancy with a radial effective gravity. This electric gravity varies in space and may change its sign depending on the temperature gradient and the cylinder radius ratio. The linear stability problem is solved by a spectral-collocation method. The critical mode is stationary and non-axisymmetric. The critical Rayleigh number and wavenumbers depend sensitively on the electric gravity and the radius ratio. The mechanism behind the instability is examined from an energetic viewpoint. The instability in wide gap annuli is an exact analogue to the gravity-driven thermal instability.
Evaluating CASP4 predictions with physical energy functions

Physical energy scoring functions based on implicit solvation models are tested by evaluating predictions from the most recent CASP4 competition. The best performing scoring functions are identified along with the best protocol for preparing structures before energies are evaluated. Ranking of structures with the best scoring functions is compared across CASP4 targets to establish when physical scoring functions can be expected to reliably distinguish structures that are most similar to the native fold in a set of misfolded or unfolded protein conformations. The results are used to interpret previous studies where scoring functions were tested on the standard decoy sets by Park, Levitt, and Baker. We show that the best physical scoring functions can be applied successfully in automated consensus scoring applications where a single best conformation has to be selected from a set of structures from different sources. Finally, the potential for better protein structure scoring functions is discussed with a suggestion for an empirically parameterized linear combination of energy components. Proteins 2002;49:232–245. © 2002 Wiley‐Liss, Inc.
Studies on sand fly fauna and ecological analysis of Phlebotomus orientalis in the highland and lowland foci of kala-azar in northwestern Ethiopia

Background Visceral leishmaniasis (VL) also known as kala-azar is a growing health problem in Ethiopia with an estimated annual VL incidence between 3700 and 7400. The disease is mainly endemic in northwestern parts of the country. The aim of the current study was to determine the sand fly fauna and ecology of Phlebotomus orientalis in two endemic and ecologically distinct areas of northwestern Ethiopia. Methods Sand flies were collected using CDC light traps, sticky traps and pyrethrum spray catches from peri-domestic, mixed forest, farm field and indoor habitats from both Libo-Kemkem (May 2011-April 2012) and Metema (October 2012-September 2013) districts. Results A total of 51,411 sand fly specimens were collected and identified (10,776 from highland and 40, 635 from the lowland areas). Seven species were found in the highland area: two Phlebotomus spp. (P. orientalis and P. rodhaini) and five Sergentomyia species. Whereas 19 species were found in the lowland area: six Phlebotomus (P. orientalis, P. rodhaini, P. bergeroti, P. duboscqi, P. papatasi and P. martini) and 13 Sergentomyia species. Of the Phlebotomus spp. , P. orientalis was the predominant species in both the highland (99.9%) and lowland (93.7%) areas. Indoor collections using pyrethrum spray catches and sticky traps indicated that P. orientalis has a strong exophilic and exophagic behaviors in both districts. In both areas, this species showed seasonal occurrence and showing abundance during the dry months (March-May/June) of the year and increasing in numbers till the rain season, when numbers dropped dramatically. Mean density of P. orientalis in the two areas had positive and significant correlation with mean temperature in light trap collections (P<0.05). However, mean density of P. orientalis in the two areas in sticky trap collections had positive and insignificant association with the temperature (P>0.05). Regarding the rainfall pattern, density of P. orientalis had negative and statistically insignificant correlation (for light trap collections for both areas) and significant correlation (for sticky trap collections for lowland area). Conclusions The current study indicated the variation in sand fly fauna between the highland and lowland districts, wherein, P. orientalis was found to be the most abundant Phlebotomus species. The study also determined that P. orientalis exhibits distinct seasonality, where its abundance increases during the dry season and disappears when the rainy period starts in both study areas. This entomological observation on the bionomics of P. orientalis provides significant evidence for considering vector control or preventive measures in the areas studied.