Miracle-dz/UniFAR-FTUs huggingface dataset:
Propagation of long fractures in the Ronne Ice Shelf, Antarctica, investigated using a numerical model of fracture propagation

Abstract Long rifts near the front of the Ronne Ice Shelf, Antarctica, are observed to begin as fractures along the lateral boundaries of outlet streams feeding the shelf. These flaws eventually become the planes along which tabular icebergs calve. The fractures propagate laterally as they advect through the shelf, with orientations that can be explained by the glaciological stress field. Fracture length remains constrained over much of the advective path, and locations of crack tip arrest are observed to coincide with structural boundaries, such as suture zones between ice from adjacent outlet glaciers. Geomechanical principles and numerical models demonstrate that in the absence of these suture zones crack tips are unlikely to arrest in these locations. We conclude that lateral inhomogeneity in the ice plays an important role in fracture mechanics through most of the ice shelf. Only near the shelf front are these local structural effects overcome such that the large rifts required for tabular iceberg production develop.
Applause as an achievement-based reward during a computerised self-assessment test

Affective feedback during a self-assessment test could help induce the learner to an optimal emotional state regarding the learning material. However, there is a lack of experimental evidence concerning the influence of affective feedback during a self-assessment test. This paper is a step towards this direction. The effect of achievement-based reward feedback on students' state and trait anxiety was examined. Ninety-two students participated in an experiment. Half of these students received an applause sound after a correct answer to a question. Results highlight gender differences concerning this emotional type of feedback. [ABSTRACT FROM AUTHOR]
Modulation of rabbit sinoatrial node activation sequence by acetylcholine and isoproterenol investigated with optical mapping technique

Aims: Changes in the rabbit sinoatrial node (SAN) activation sequence with the cholinergic and adrenergic factors were studied. The correlation between the sinus rhythm rate and the leading pacemaker site shift was determined. The hypothesis concerning the cholinergic suppression of nodal cell excitability as one of the mechanisms associated with pacemaker shift was tested.
Existing Antilisterial Immunity Does Not Inhibit the Development of a Listeria monocytogenes-Specific Primary Cytotoxic T-Lymphocyte Response

ABSTRACT Infection of BALB/c mice with Listeria monocytogenesstimulates an antilisterial immune response evident by the appearance of H2-Kd-restricted CD8+ cytotoxic T lymphocytes (CTLs) specific for the nanomer peptides amino acids (aa) 91 to 99 of listeriolysin O (LLO 91–99) and aa 217 to 225 of the p60 molecule (p60 217–225). We have introduced point mutations at anchor residues within LLO 91–99 (92F) or p60 217–225 (218F), and BALB/c mice infected with L. monocytogenes strains containing these point mutations do not develop CTLs specific for LLO 91–99 or p60 217–225, respectively. We have used these strains to test whether primary CTL responses against L. monocytogenes-derived determinants can be stimulated within an environment of existing antilisterial immunity. We found that the development of a primaryL. monocytogenes-specific CTL response is not altered by existing immunity to L. monocytogenes. For example, primary immunization with the p60 218F strain of L. monocytogenesfollowed by a secondary immunization with wild-type L. monocytogenes results in stimulation of p60 217–225-specific CTLs at primary response levels and LLO 91–99-specific effectors at levels consistent with a memory CTL response. Similarly, primary immunization with the 92F strain of L. monocytogenesfollowed by a secondary immunization with wild-type L. monocytogenes results in stimulation of LLO 91–99-specific CTLs at primary response levels and p60 217–225-specific effectors at levels consistent with a memory CTL response. These results provide additional support for the use of L. monocytogenes as a recombinant vaccine vector and show that antivector immunity does not inhibit the development of a primary CTL response when the epitope is delivered by L. monocytogenes as the vaccine strain.
Nonoperative Management of Acute Upper Limb Ischemia

Background: Acute upper limb ischemia (AULI) is an uncommon emergency warranting immediate evaluation and treatment. The role of nonsurgical therapies including endovascular techniques, thrombolytics, and anticoagulation remains undefined. The authors systematically reviewed the current literature on the nonsurgical treatment of acute ischemia of the upper extremity. Methods: A PubMed and Embase search was conducted, and articles were screened using predetermined criteria. Data collected included patient demographics, cause of upper limb ischemia, type of nonsurgical treatment used, treatment outcomes, and complications. Patients were divided into 4 treatment groups: catheter embolectomy, catheter-directed thrombolysis, endovascular stenting, and anticoagulation/medical therapy alone. Results: Twenty-three retrospective studies met the search criteria. Of 1326 reported occlusions, 92% (1221) were attributed to thromboembolic disease. The second most common cause was iatrogenic (1.5%). Overall limb salvage rates were excellent with catheter embolectomy (862 of 882 cases, 97.7%) and catheter-directed thrombolysis (110 of 114 cases, 96.5%). Limb salvage rates were also high with anticoagulation/medical therapy (158 of 165 cases, 95.8%), but poor functional outcomes were more often reported. Conclusions: High-quality evidence to guide the nonsurgical treatment of AULI is lacking. Retrospective studies support the utility of catheter-based embolectomy and thrombolysis for distal ischemia. Whether a surgical or nonsurgical approach is taken, anticoagulation therapy remains a mainstay of both treatment and prevention of AULI. Because AULI patients often have underlying cardiac and/or systemic disease, a multidisciplinary approach is essential to minimize complications and prevent future occurrences.
Screening and management of maternal colonization with Streptococcus agalactiae: an Italian cohort study

Abstract Introduction: Streptococcus agalactiae (Group B streptococcus [GBS]) is the most common cause of sepsis and meningitis in infants <3 months of age. Intrapartum antibiotic prophylaxis (IAP) is effective in preventing the transmission of GBS to newborns. The Centers for Disease Control and Prevention (CDC) guidelines suggest vaginal and rectal cultures to assess GBS colonization between 35 and 37 weeks’ gestation. Methods: Between July and December 2013, we identified 535 women admitted to the Obstetric and Gynecology Unit of Cardarelli Hospital (Campobasso, Italy) for delivery. We evaluated the indications for IAP, complete execution of IAP, and neonatal outcomes. Results: Our sample included 468 women and 475 live births. Correct screening for GBS was executed in 241 cases (51.5%), the number of women colonized was 96 (30.2%), and 136 women had indications to receive IAP, but only 68 (50%) received adequate treatment. Conclusions: GBS colonization status should be determined by collecting both vaginal and rectal specimens at 35–37 weeks’ gestation. Inadequate screening for GBS and incorrect IAP led to an increased incidence of early-onset disease in newborns. Local public health agencies should promote surveillance and educational programs to prevent neonatal GBS infections.
Surgical revascularisation in patients with severe limb ischaemia induces a pro-thrombotic state

Platelet and coagulation activation are implicated in the increased incidence of ischaemic events seen in patients with peripheral arterial disease. This study aimed to assess the effect of surgical revascularisation on platelet aggregation and coagulation in patients with severe limb ischaemia (SLI). Twenty-two patients had blood samples taken: prior to surgery, on reperfusion, 2, 24 and 48 h post-surgery. Platelet aggregation through COX-mediated and thrombin receptor activator peptide (TRAP)-stimulated GPIIb/IIIa pathways was measured by the Ultegra point of care system. Thrombin-antithrombin III Complex (TAT) and D-dimer were measured by ELISA. COX-mediated aggregation increased significantly at reperfusion and remained elevated at 24 h [median increase from baseline of 9% (range −16 to 33%) P = 0.011]. TRAP-stimulated aggregation increased significantly at reperfusion and remained elevated at 2 h post-surgery [median increase 18% (range −71 to 45%); P = 0.007]. TAT levels were significantly elevated from reperfusion and remained so at 48 h (P < 0.003), whereas D-dimer only increased at 24 h (P = 0.014). For the first time, we have demonstrated that in patients with SLI, platelet aggregation is increased following surgery and there is a mismatch in the balance between the coagulation and fibrinolytic pathways despite the use of aspirin and heparin. Thus in the early post-operative these patients exhibit a pro-thrombotic state.
Management of Riga-Fede disease: a case report

The treatment of a case of traumatic ulceration of the tongue (Riga-Fede disease) is described. A 12 month-old female patient, with cerebral palsy, presented with a widespread non-cicatrised yellowishwhite ulcer on the ventral surface of the tongue, which was causing pain and refusal to eat. A very conservative approach was adopted, based on the use of an acrylic lower mouth guard, the smoothing of the incisal edges of the lower incisors, and the topical application of an obtundant gel.
Incidence of reflux esophagitis and H pylori infection in diabetic patients.

AIM To investigate the incidence of reflux esophagitis (RE) and H pylori infection in the diabetic patient. METHODS The incidence of RE and H pylori infection were investigated in 85 patients with diabetes mellitus and the results were compared with controls. RESULTS The incidence of RE in diabetic patients was 17.6%. Although this tended to be higher in diabetic patients, there were no statistically significant differences between diabetic patients and controls. The incidence of H pylori infection in diabetic patients was 53.7% but no statistically significant difference was seen between diabetic patients and controls in the incidence of H pylori infection. CONCLUSION No significant differences could be seen between diabetic patients and controls in the incidence of RE and H pylori infection.
Connexin Expression Patterns in the Rat Cornea: Molecular Evidence for Communication Compartments

Purpose. To identify and localize candidate connexin family members in adult rat cornea that may be important in coordinating corneal cell biology. Methods. To identify candidate connexin family members in adult rat cornea, a RT-PCR–based screening approach was initially adopted. Fourteen pairs of connexin isoform-specific primers were used to amplify connexin transcripts from two populations of RNA isolated from either the central cornea or the whole cornea. Immunohistochemistry and confocal microscopy were then used to confirm the presence and localization of connexins. Results. Eight connexin transcripts (Cxs 26, 30.3, 31, 31.1, 33, 37, 43, 50) are present in central cornea, and the peripheral cornea additionally expresses Cxs 30, 40, 45, and 46. No Cx32 or Cx36 transcripts were amplified. Immunohistochemistry revealed that Cxs 26, 30, 31.1, 37, and 43 are expressed in spatially distinct patterns within the cornea. Cx26 and Cx43 occur in basal cells of the whole corneal epithelium and between endothelial cells. Cx26 also immunolocalizes to the first layer of intermediate epithelial cells, and Cx43 antibody labels stromal keratocytes. Cx30 is expressed in the peripheral corneal epithelium and disappears toward the central cornea. Cx31.1 expression is restricted to superficial corneal epithelial cells, and Cx37 spans the intermediate corneal epithelium. Conclusion. The spatially distinct cellular expression patterns of Cxs 26, 30, 31.1, 37, and 43 in the corneal epithelium imply that gap junctions play important roles in controlling corneal epithelial proliferation and differentiation and overall corneal maintenance.
Prevalence of Coxiella Burnetii in Ticks After a Large Outbreak of Q Fever

Q fever has emerged as an important human and veterinary public health problem in the Netherlands with major outbreaks in three consecutive years. Goat farms are probably the prime source from which Coxiella burnetii have spread throughout the environment, infecting people living in the vicinity. Coxiella burnetii infection not only spilled over from animal husbandry to humans but could also have spread to neighbouring wildlife and pets forming novel reservoirs and consequently posing another and lingering threat to humans, companion animals and livestock. In these cases, transmission routes other than airborne spread of contaminated aerosols may become significant. Therefore, the role of ticks in the transmission of Coxiella burnetii in the current situation was investigated. A total of 1891 questing Ixodes ricinus ticks and 1086 ticks feeding on pets, wildlife and livestock were tested by a recently developed multiplex Q‐PCR. All ticks were negative, except for a few ticks feeding on a herd of recently vaccinated sheep. Coxiella‐positive ticks were not detected after resampling this particular herd three months later. Based on these data we conclude that the current risk of acquiring Q fever from questing ticks in the Netherlands is negligible. However, for future risk assessments, it might be relevant to sample more ticks in the vicinity of previously C. burnetii infected goat farms and to assess whether C. burnetii can be transmitted transovarially and transstadially in I. ricinus ticks.
Recruiting U.S. and Canadian college students via social media for participation in a web-based brief intervention study.

OBJECTIVE Recruiting young adults for health research is challenging. Social media provides wide access to potential research participants. We evaluated the feasibility of recruiting students via free message postings on Facebook and Twitter to participate in a web-based brief intervention study. The sample comprised students attending U.S. and Canadian universities. METHOD During three semesters, institutional review board-approved recruitment messages were posted in 281 Facebook groups, 7 Facebook pages, and 27 message "tweets" on Twitter. RESULTS A total of 708 eligible participants were recruited from Facebook. The mean enrollment rate per Facebook group was 0.21%; the rate was higher for host university groups (1.56%) compared with groups at other universities (0.10%). We recruited seven participants from Twitter. The sample was predominantly female (70%) with a mean age of 20.0 years. There were no significant differences between host university participants recruited through social media and traditional methods. The web-based intervention completion rate was 65%, and participants from the host university were more likely to complete the intervention than were groups at other universities (p = .01). CONCLUSIONS Social media provides access to a large number of potential participants, and social media recruitment may be useful to researchers who can harness this broad reach. Facebook recruitment was feasible and free and resulted in a large number of enrolled participants. Social media recruitment for researchers at their own universities may be particularly fruitful. Despite wide access to students with Twitter, recruitment was slow. Social media recruitment allowed us to extend web-based intervention access to students in the United States and Canada.
Therapeutic effects of Lactobacillus in treating irritable bowel syndrome: a meta-analysis.

OBJECTIVE As the lack of reliable treatment for irritable bowel syndrome (IBS) prompts interest in the development of new therapies, we aimed to systematically evaluate the effect of Lactobacillus in treating this disease. METHODS We searched MEDLIINE, PubMed, Scopus, Web of Science and the Cochrane Central Register of Controlled Trials for the period from 1966 to August 2013 for double-blind, placebo-controlled trials investigating the efficacy of Lactobacillus treatment in the management of IBS. The studies were screened for inclusion based on randomization, controls and reported measurable outcomes. We used the Jadad score to assess the quality of the articles. The STATA 11.0 and Revman 5.0 software packages were used for the meta-analysis. The STATA 11.0 software program was also used to assess indicators of publication bias according to Begg's and Egger's tests. RESULTS Six randomized, placebo-controlled clinical trials met the criteria and were included in the meta-analysis. The Jadad score of the articles was >3, and three articles were of high quality. We analyzed the heterogeneity of the studies and found no heterogeneity in the meta-analysis. In the forest plot, the diamond was on the right side of the vertical line and did not intersect with the line. The pooled relative risk for clinical improvement with Lactobacillus treatment was 7.69 (95% confidence interval: 2.33-25.43, p=0.0008). For adults, the pooled relative risk for clinical improvement with Lactobacillus treatment was 17.62 (95% confidence interval: 5.12-60.65, p<0.00001). For children, the pooled relative risk for clinical improvement with Lactobacillus treatment was 3.71 (95% confidence interval:1.05-13.11, p=0.04). Using the STATA 10.0 and Revman 5.0 software programs, we confirmed that Lactobacillus exhibited significant efficacy in treating IBS. CONCLUSION Compared with the placebo, Lactobacillus treatment was found to be associated with a significantly higher rate of treatment responders in the overall population with IBS, without any side effects. As to limitations of the analysis, additional research is needed.
Spatial Effects of European Integration: Do Border Regions Benefit Above Average?

A basic result of new economic geography (NEG) models is that the proximity to consumer markets impacts wages and employment within regions. The ongoing process of European integration, being targeted on the reduction of barriers to trade and factor mobility, has presumably changed relative market access in Europe. The present paper aims at providing some evidence on spatial effects of integration released by declining border impediments and changing market potentials. The analysis departs from a threeregion economic geography model. We focus on the impact of integration on European border regions and the question whether they realise above average integration benefits. The empirical analysis concerns integration effects in the EU15 regions arising from a reduction of non-tariff and other barriers since the mid 1970s.
An OCR system to read two Indian language scripts: Bangla and Devnagari (Hindi)

An OCR system is proposed that can read two Indian language scripts: Bangla and Devnagari (Hindi), the most popular ones in the Indian subcontinent. These scripts, having the same origin in ancient Brahmi script, have many features in common and hence a single system can be modeled to recognize them. In the proposed model, document digitization, skew detection, text line segmentation and zone separation, word and character segmentation, character grouping into basic, modifier and compound character category are done for both scripts by the same set of algorithms. The feature sets and classification tree as well as the knowledge base required for error correction (such as lexicon) differ for Bangla and Devnagari. The system shows a good performance for single font scripts printed on clear documents.
A Program on Prevention of Mother to Child Transmission of HIV at Government Hospital, Tiruchengode Taluk, Namakkal District

UNAIDS states that mother to child transmission (MTCT) is the largest source of HIV infection in children below the age of 15 years. (1) According to National AIDS Control Organization (NACO), it is estimated that about 30,000 infants acquire HIV infection each year. (2) Tamil Nadu Sentinel surveillance for 2004, showed that the median positivity rate of HIV infection among the antenatal women was 0.65% (range 0-3.7%)(3) and in 2005 it was 0.50%. Prevention of mother to child transmission (PMTCT) program has been established at the Tiruchengode government hospital (Tiruchengode taluk, Namakkal district) in November 2002 by the Department of Experimental Medicine of the Tamilnadu Dr. MGR Medical University. This was the first PMTCT program in India that has been established at a taluk hospital. The objective of the program was to establish a PMTCT center and offer antiretroviral prophylaxis to all HIV positive pregnant women and their infants.
B7-H6-mediated downregulation of NKp30 in NK cells contributes to ovarian carcinoma immune escape

In this study the phenotype and function of tumor-associated NK cells from peritoneal fluids of a selected cohort of patients with seropapillary ovarian carcinoma were analyzed. In > 50% of these patients, the expression of the activating receptor NKp30 in tumor-associated NK cells was substantially reduced as compared to autologous peripheral blood (PB) NK cells. The impaired expression of this receptor was associated with the presence of one of its cellular ligands (B7-H6), which was detectable as a surface/cytosolic molecule in tumor cells and as a soluble molecule in the peritoneal fluid. NK cells from patients expressing this NKp30low phenotype displayed an impaired interferon-gamma (IFNγ) production and cytolytic function when tested against target cells expressing surface B7-H6. Our data also suggest that in these patients, the defective expression and function of NKp30 may be induced by the chronic engagement of this receptor by soluble B7-H6 or by tumor cells expressing this ligand. The impairment of NK cell functions described herein could represent a novel mechanism by which the tumor microenvironment may contribute to the escape from immune surveillance.
Spatial and Temporal Patterns in Cimex lectularius (Hemiptera: Cimicidae) Reporting in Philadelphia, PA

ABSTRACT We analyzed a comprehensive telephone log of pest infestation reports to assess the spatial and temporal trends in Cimex lectularius L. (bed bug) reporting throughout Philadelphia, PA. Citywide spatial analyses of reports from September 2011 to June 2012 revealed several statistically significantbed bug hotspots. However, these were small and diffuse. Temporal analyses of reports from December 2008 to May 2011 detected prominent seasonality in bed bug reporting, peaking in August and reaching a nadir in February each year. Controlling for seasonal cycling, the number of bed bug reports in Philadelphia increased steadily at a rate of ≈4.5% per month (or 69.45% per year) from December 2008 to May 2011. While it may be difficult to spatially target citywide bed bug control measures because of the insects' widespread migration, interventions informed by seasonal trends may enhance efforts to curb the recent increases in urban bed bug populations.