Miracle-dz/UniFAR-FTUs huggingface dataset:
Decitabine in myeloid malignancies

Myelodysplastic syndromes Myelodysplastic syndromes (MDS) are a group of bone marrow disorders that mainly occur in the elderly and are characterized by ineffective hematopoiesis resulting in anemia, neutropenia, and thrombocytopenia,1 MDS can occur spontaneously (primary or de novo) or can occur as a result from exposure to chemotherapy or chemicals including benzene and others (secondary). 1,2,3 MDS is seen in approximately 5 per 100,000 people.4 Risk factors for MDS include age, previous chemotherapy, and exposure to environmental toxins, tobacco and gender (male). 5 Approximately half of MDS patients are asymptomatic at the time of initial diagnosis and are diagnosed only after routine laboratory tests showing peripheral blood abnormalities. 1 Although MDS can eventually result in neutropenia and/or thrombocytopenia, anemia is the most common characteristic at the time of initial diagnosis.
Barriers and motivators to attaining a school-based MA inEducation: a case study

A school-based master’s programme was provided for teachers at a comprehensive in the East End of London, UK. Two traditional barriers to doing an MA (cost and travelling time) were removed. The study explores the extent to which teachers’ workload, family commitments and other external factors impact on the retention of MA participants. It was found that heavy job and family obligations were not necessarily predictors of failure to complete the course, and that personal values and aspirations had a greater bearing on attaining the award than work/life balance. It emerged that the minority ethnic backgrounds of the teachers interviewed might well be a significant factor in their determination to attain a master’s degree.
Predictors of Educational Outcomes among Undergraduate Students with Disabilities

ii Dedication . v Acknowledgements . vi Vita . vii List of tables . x List of figures . ii Chapter 1: Introduction . 1 Background . 1 Research questions . 10 Chapter 2: Literature Review . 11 Conceptual framework . 11 Inputs.11 Outputs . 23 Chapter 3: Methodology . 28 Sample.28 Design . 28 Data collection . 29 Measures . 29
Language and Literacy in the Early Years

PART ONE: LANGUAGE AND LEARNING Linguistics The Study of Language Key Terms Linguistics Grammars Systems and Signs Teaching and Learning Suggestions Sociolinguistics Language and Cultures Language Variety Power and Influence Language Change Multilingualism Teaching and Learning Suggestions Psycholinguistics Early Language Acquisition Key Terms Early Language Acquisition How Do We Do It? Stages in Speech and Language Development Teaching and Learning Suggestions Language and Thinking Key Terms Views and Perspectives Brainy Babies Teaching and Learning Suggestions The Early-Years Educator and Knowledge about Language From Theory to Practice? Language Knowledge and the Educators Language Study in Early Years Settings Language in Social Contexts Multilingualism in Early Years Settings Language Variety and Standard English Language, Thinking and Learning PART TWO: LITERACY Narrative and Storying Key Terms Narrative Storying Teaching and Learning Suggestions Books and the World of Literature Key Terms Early Experiences with Books Literature and Becoming Literate Teaching Reading and Supporting Readers Teaching and Learning Suggestions Early Representation and Emerging Writing Key Terms Process and Product Literacy, Culture and Schooling Early Representation and Symbolizing Symbols and the Creation of Meanings Emerging Writing Appropriate Practices Teaching and Learning Suggestions The Early Years Educator and Literacy The Literacy Approach Getting Started Emerging Literacy Early Literacy and Nursery Curriculum Parents, Families, Communities and Cultures Records and Assessment
Comparison of intravenous lignocaine and intravenous dexmedetomidine for attenuation of hemodynamic stress response to laryngoscopy and endotracheal intubation

Context: Direct laryngoscopy and endotracheal intubation following induction of anesthesia is almost always associated with hemodynamic stress response due to reflex sympathoadrenal discharge. Aim: Aim of our study was to compare the efficacy of lignocaine and dexmedetomidine in attenuating the hemodynamic response to laryngoscopy and intubation. Settings and Design: The present prospective randomized study was carried out in a tertiary care teaching hospital. A total of 100 American Society of Anesthesiologist physical status I and II patients posted for elective surgery under general anesthesia were enrolled in the study. Patients were randomly divided into two groups, group L (lignocaine group) and group D (dexmedetomidine group) with 50 patients in each group. Materials and Methods: Group L received 1.5 mg/kg of lignocaine intravenous (IV) and group D received 1 mcg/kg of dexmedetomidine as IV infusion. Thiopentone was given until eyelash reflex disappeared, and intubation was facilitated with succinylcholine. Anesthesia was maintained with 33:66 oxygen: Nitrous oxide, isoflurane, and vecuronium. Hemodynamic parameters were recorded during the basal period, preinduction, after induction, during intubation, 1 min, 3 min, 5 min, and 10 min after intubation. Statistical Analysis Used: Data were analyzed using Graphpad Prism Software version 6.03 (Graphpad Software Inc., USA). P Results: Maximum increase in heart rate was around 38% in group L and 10% in group D (P = 0.000). Maximum increase in mean arterial pressure was 22% in group L and 6% in group D (P = 0.000). Thiopentone dose requirement was 19% less in group D compared to group L (P Conclusion: Dexmedetomidine attenuates the hemodynamic stress response to laryngoscopy and intubation more effectively compared with lignocaine without any deleterious effects. Furthermore, dexmedetomidine decreases dose of thiopentone for induction of anesthesia.
Perceived and measured health benefits of aqua-based exercise for older adults with osteoarthritis

Ageing is associated with a number of physiological and psychological changes. These include declines in muscle mass, strength, functional ability, and balance, which are associated with increased risk of falling and reduced quality of life. In addition, many older adults have osteoarthritis and the associated symptoms of joint pain and stiffness may exacerbate the age-related changes in physical function. Regular exercise can help offset the age-related declines in muscle strength, functional ability and balance, however many older adults do not regularly exercise. In particular older adults with osteoarthritis tend to have lower levels of physical activity than older adults without osteoarthritis. Aqua-based exercise is recommended for older adults with osteoarthritis due to the properties of water, however relatively few studies have investigated this type of exercise among this population. The first aim of this thesis was to investigate perceived benefits and barriers to participation in aqua-based exercise among older adults with and without osteoarthritis, who regularly engage in this form of exercise. The key perceived benefit for those with osteoarthritis was pain reduction, whilst those without osteoarthritis identified general health and fitness as the primary benefit. Both groups identified social interaction as an important benefit. Cold changing facilities, particularly during winter, was a key potential barrier for both groups. The second study examined perceived barriers and benefits of aqua-based exercise among older adults with osteoarthritis who had tried, but no longer participated in aqua-based exercise. Key barriers were a lack of suitable classes and insufficient instructor knowledge, as well as cold changing facilities and pool temperature. Benefits included the cushioning effect of the water and the ability to move around more freely.
Information recovery from rank-order encoded images

The time to detection of a visual stimulus by the primate eye is recorded at 100 – 150ms. This near instantaneous recognition is in spite of the considerable processing required by the several stages of the visual pathway to recognise and react to a visual scene. How this is achieved is still a matter of speculation. Rank-order codes have been proposed as a means of encoding by the primate eye in the rapid transmission of the initial burst of information from the sensory neurons to the brain. We study the efficiency of rank-order codes in encoding perceptually-important information in an image. VanRullen and Thorpe built a model of the ganglion cell layers of the retina to simulate and study the viability of rank-order as a means of encoding by retinal neurons. We validate their model and quantify the information retrieved from rank-order encoded images in terms of the visually-important information recovered. Towards this goal, we apply the ‘perceptual information preservation algorithm’, proposed by Petrovic and Xydeas after slight modification. We observe a low information recovery due to losses suffered during the rank-order encoding and decoding processes. We propose to minimise these losses to recover maximum information in minimum time from rank-order encoded images. We first maximise information recovery by using the pseudo-inverse of the filter-bank matrix to minimise losses during rankorder decoding. We then apply the biological principle of lateral inhibition to minimise losses during rank-order encoding. In doing so, we propose the Filteroverlap Correction algorithm. To test the perfomance of rank-order codes in a biologically realistic model, we design and simulate a model of the foveal-pit ganglion cells of the retina keeping close to biological parameters. We use this as a rank-order encoder and analyse its performance relative to VanRullen and Thorpe’s retinal model.
Upper Extremity Kinematics in Pediatric and Young Adult Populations during Activities of Daily Living

Age-related differences in upper extremity (UE) kinematics during activities of daily living are poorly understood. To develop control databases for clinical studies, a greater understanding of UE mechanics and potential changes in motion as a function of age is needed. The purpose of this research was to examine age-related differences in threedimensional UE kinematics between young adult and pediatric groups while performing activities of daily living. Fifteen young adults (n=15) aged 18-24 years (mean age: 20.2 years) and fifteen pediatric participants (n=15) aged 7-9 years (mean age: 8.3 years) participated in the study. An eight-camera Vicon MCam system was used to record UE motion during the performance of three tasks: drinking, eating, and a simulated perineal care task. Significant differences in mean maximum joint angles were found between the age groups for all three tasks. No significant differences were found in kinematics data between the dominant and non-dominant arms for any task. Differential UE movement patterns may exist due to differences in experience with the tasks, anthropometrics, techniques used to complete the task, and/or neuromaturational levels. These results emphasize the need for age-matched control data for clinical studies of UE motion.
Recession: a chance for hospitality SMEs?

Purpose – The research takes a comprehensive evaluation of hospitality students’ perceptions towards small and medium sized enterprises (SMEs) employment and explores whether the current recession and labour market changes influence hospitality students career-related decisions. Such exploration would provide vital information as to how the new economic environment has modified the nature and context of hospitality students perceptions towards SMEs. The paper aims to discuss these issues. Design/methodology/approach – The research focuses on a constructionist philosophy in order to interpret how hospitality students construct of career choice. The qualitative methodology adopts semi-structured interviews in order to explore the socially constructed views of hospitality students’ perception of SMEs employment. Findings – In spite of recessional challenges which particularly affect the graduate labour market, the research confirms the original academic arguments that socially constructed barriers and influe.
The Post-Crisis Slump in the Euro Area and the US: Evidence from an Estimated Three-Region DSGE Model

The global financial crisis (2008-09) led to a sharp contraction in both Euro Area (EA) and US real activity, and was followed by a long-lasting slump. However, the post-crisis adjustment in the EA and the US shows striking differences—in particular, the EA slump has been markedly more protracted. We estimate a three-region (EA, US and Rest of World) New Keynesian DSGE model (using quarterly data for 1999-2014) to quantify the drivers of the divergent EA and US adjustment paths. Our results suggest that financial shocks were key drivers of the 2008-09 Great Recession, for both the EA and the US. The post-2009 slump in the EA mainly reflects a combination of adverse aggregate demand and supply shocks, in particular lower productivity growth, and persistent adverse shocks to capital investment, linked to the continuing poor health of the EA financial system. Adverse financial shocks were less persistent for the US. The financial shocks identified by the model are consistent with observed performance indicators of the EA and US banking systems.
ICLR 2019 Natural Adversarial Natural Adversarial Natural Adversarial “ revolver ” “ mousetrap ” “ vulture ” “ orangutan ” “ ship ” “ dog ”

We show that simple spatial transformations, namely translations and rotations alone, suffice to fool neural networks on a significant fraction of their inputs in multiple image classification tasks. Our results are in sharp contrast to previous work in adversarial robustness that relied on more complicated optimization approaches unlikely to appear outside a truly adversarial context. Moreover, the misclassifying rotations and translations are easy to find and require only a few black-box queries to the target model. Overall, our findings emphasize the need to design robust classifiers even for natural input transformations in benign settings.
Renaud pump inactivation : implications for fatigue +-K + disturbances and Na − , and Cl + , Na + Muscle

[PDF] [Full Text] [Abstract] , September , 2009; 24 (9): 2882-2888. Nephrol. Dial. Transplant. McKenna Aaron C. Petersen, Murray J. Leikis, Lawrence P. McMahon, Annette B. Kent and Michael J. performance in patients on haemodialysis Effects of endurance training on extrarenal potassium regulation and exercise [PDF] [Full Text] [Abstract] , November 15, 2010; 588 (22): 4549-4562. J Physiol Louise Boudreault, Carlo Cifelli, François Bourassa, Kyle Scott and Jean-Marc Renaud channels ATP muscles with non-functioning K Fatigue preconditioning increases fatigue resistance in mouse flexor digitorum brevis [PDF] [Full Text] [Abstract] , April 4, 2011; . Br J Sports Med Lira and Maria Augusta P D M Kiss F Pires, Timothy D Noakes, Adriano E Lima-Silva, R Bertuzzi, Carlos Ugrinowitsch, Fabio S exercises performed at different intensities until exhaustion Cardiopulmonary, blood metabolite and rating of perceived exertion responses to constant [PDF] [Full Text] [Abstract] , June , 2011; 110 (6): 1598-1606. J Appl Physiol Scott R. Murgatroyd, Carrie Ferguson, Susan A. Ward, Brian J. Whipp and Harry B. Rossiter humans uptake kinetics as a determinant of high-intensity exercise tolerance in 2 Pulmonary O [PDF] [Full Text] [Abstract] , April 4, 2011; . Br J Sports Med Fabio S Lira and Maria Augusta P D M Kiss Flávio O Pires, Timothy D Noakes, Adriano E Lima-Silva, R Bertuzzi, Carlos Ugrinowitsch, exercises performed at different intensities until exhaustion Cardiopulmonary, blood metabolite and rating of perceived exertion responses to constant
Corporate Governance, Affirmative Action and Firm Value: Evidence from Post-Apartheid South African Firms

Research Question/Issue: The post-Apartheid South African (SA) corporate governance (CG) model is a unique hybridisation of the traditional Anglo-American and Continental European-Asian CG models, distinctively requiring firms to explicitly comply with a number of affirmative action and stakeholder CG provisions, such as black empowerment and HIV/Aids. This paper examines the association between a broad CG index and firm value in this distinct corporate setting. Research Findings/Insights: Using a sample of 169 post-Apartheid SA firms from 2002 to 2007, we find a significant positive association between a broad CG index and firm value, as proxied by Tobin’s Q. Distinct from prior studies, but consistent with political cost, legitimacy and resource dependence theories, we find that compliance with affirmative action CG provisions impacts positively on firm value. The results are robust across a number of econometric models that control for different types of endogeneity, accounting and market-based firm valuation measures. Theoretical/Academic Implications: The paper contributes to the literature on the association between compliance with codes of good governance and firm value by specifically modelling the relationship within a unique institutional, legal and CG environment. Distinctively, we contribute to the literature by showing how affirmative action and stakeholder CG provisions impact on firm value. Practical/Policy Implications: The results have important policy implications for companies and regulators. They suggest that investors reward firms with better CG practices with higher market valuation, providing support to the efforts by various stakeholders at improving CG standards in SA companies. The results also suggest that SA companies who pay serious attention to complying with affirmative action and stakeholder CG provisions may reap benefits in the form of higher firm value.
Observations and modelling of CO and [C i] in protoplanetary disks - First detections of [C i] and constraints on the carbon abundance

Context. The gas-solid budget of carbon in protoplanetary disks is related to the composition of the cores and atmospheres of the planets forming in them. The principal gas-phase carbon carriers CO, C0, and C+ can now be observed regularly in disks. Aims: The gas-phase carbon abundance in disks has thus far not been well characterized observationally. We obtain new constraints on the [C]/[H] ratio in a large sample of disks, and compile an overview of the strength of [C i] and warm CO emission. Methods: We carried out a survey of the CO 6-5 line and the [C i] 1-0 and 2-1 lines towards 37 disks with the APEX telescope, and supplemented it with [C ii] data from the literature. The data are interpreted using a grid of models produced with the DALI disk code. We also investigate how well the gas-phase carbon abundance can be determined in light of parameter uncertainties. Results: The CO 6-5 line is detected in 13 out of 33 sources, [C i] 1-0 in 6 out of 12, and [C i] 2-1 in 1 out of 33. With separate deep integrations, the first unambiguous detections of the [C i] 1-0 line in disks are obtained, in TW Hya and HD 100546. Conclusions: Gas-phase carbon abundance reductions of a factor of 5-10 or more can be identified robustly based on CO and [C i] detections, assuming reasonable constraints on other parameters. The atomic carbon detection towards TW Hya confirms a factor of 100 reduction of [C]/[H]gas in that disk, while the data are consistent with an ISM-like carbon abundance for HD 100546. In addition, BP Tau, T Cha,
NGC 1252: a high altitude, metal poor open cluster remnant

If stars form in clusters but most stars belong to the field, un derstanding the details of the transition from the former to the latter is imperative to exp lain the observational properties of the field. Aging open clusters are one of the sources of field stars. The disruption rate of open clusters slows down with age but, as an object gets older, the distinction between the remaining cluster or open cluster remnant (OCR) and the surrounding field becomes less and less obvious. As a result, finding good OCR candidates or confi rming the OCR nature of some of the best candidates still remains elusive. One of these ob jects is NGC 1252, a scattered group of about 20 stars in Horologium. Here we use new wide-fie ld photometry in the UBV I pass-bands, proper motions from the Yale/San Juan SPM 4.0 catalogue and high resolution spectroscopy concurrently with results from N -body simulations to decipher NGC 1252’s enigmatic character. Spectroscopy shows that most of the brightest stars in the studied area are chemically, kinematically and spatially unrelated to e ach other. However, after analysing proper motions, we find one relevant kinematic group. This sp arse object is relatively close (�1 kpc), metal poor and is probably not only one of the oldest clusters (3 Gyr) within 1.5 kpc from the Sun but also one of the clusters located farthest fro m the disc, at an altitude of nearly -900 pc. That makes NGC 1252 the first open cluster that can be t ruly considered a high Galactic altitude OCR: an unusual object that may hint at a star formation event induced on a high Galactic altitude gas cloud. We also conclude that the variable TW Horologii and the blue straggler candidate HD 20286 are unlikely to be part of NGC 1252. NGC 1252 17 is identified as an unrelated, Population II cannonball star mo ving at about 400 km s 1 .
REALISTIC MATHEMATICS EDUCATION IN COOPERATIVE LEARNING VIEWED FROM LEARNING ACTIVITY

This study aimed at searching the different effect of Student Teams Achievement Division (STAD) and Think Pair Share (TPS) types of cooperative learning models with Realistic Mathematics Education (RME) approach on the students’ learning outcome viewed from students’ learning activity. The observation, interview, questionnaires, and tests were used to obtain the data which were then analyzed using two-way ANOVA. The result of research showed that: (1) STAD with RME approach provides better learning outcome than TPS with RME approach does; (2) the students with high learning activities have mathematics learning outcome better than those with medium and low learning activities; and (3) there is no interaction between the model of teaching and learning activities students to the results of the students’ mathematics learning.
1 Are investments in basic infrastructure the magic wand to boost the 2 local economy of rural communities from Romania ? 3 4

1 Department of Public Administration and Management, Babeş-Bolyai University of Cluj-Napoca, 6 Romania; pavel@fspac.ro 7 2 Department of Public Administration and Management, Babeş-Bolyai University of Cluj-Napoca, 8 Romania; moldovan@fspac.ro 9 3 Department of Public Administration and Management, Babeş-Bolyai University of Cluj-Napoca, Romania; 10 neamtu@fspac.ro 11 4 Department of Public Administration and Management, Babeş-Bolyai University of Cluj-Napoca, Romania; 12 cristina.hintea@fspac.ro 13 * Correspondence: pavel@fspac.ro; Tel. : +40-743-376-973 14