Miracle-dz/UniFAR-FTUs huggingface dataset:
Amplitude and phase synchronization of European business cycles: a wavelet approach

Abstract In the paper we suggest the use of amplitude correlation coefficients (ACCs) and phase-locking values (PLVs) in examining business cycle synchronization. The quantities are calculated on the basis of instantaneous amplitudes and phase differences, which are computed here with the help of the non-decimated discrete analytic wavelet transform. We show that the coefficients constitute an interesting add-in to the statistical apparatus of examining business cycle synchronization. The PLVs correct the information provided by the coherency and correlation coefficients for the influence of amplitude changes and are of use in examining phase synchronization of business cycles, which is important in forecasting the effectiveness of a common monetary policy. By contrast, the ACCs are based solely on amplitude information and have the interpretation of phase-adjusted correlation coefficients, which can be used to evaluate stabilization policies or to forecast these policies’ effectiveness. The methodology is applied to examine cyclical synchronization of 20 European Union (EU) countries. We show, among other things, that during the run-up to the euro both amplitude and phase synchronization increased, with the former tending to change more rapidly. Furthermore, for the new EU members an EU effect is identified in both types of cyclical synchronization with the euro area.
Obstacle avoidance strategies for autonomous surface vehicles

Autonomous Surface Vehicles (ASVs) rely on two layers of guidance for effective path planning: global and local methods. Global methods require a macroscopic view of the mission's goals in order to efficiently navigate an environment. For this research, different global path planner algorithms are explored both in simulation and in field tests to observe path planner qualities for modularity, practicality, and robustness for future integration with local, reactive obstacle avoidance. Three obstacle configurations are tested to study situational approaches for each algorithm. With appropriate inputs for path planning parameters (i.e. connection distance, number of nodes, and iterations), numerical simulations are able to find a feasible path. Results demonstrate path following robustness in response to a generic ASV craft with only a roughly tuned heading and speed controller.
Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: a double-blind, placebo-controlled trial.

BACKGROUND & AIMS Pouchitis is the major long-term complication after ileal pouch-anal anastomosis for ulcerative colitis. Most patients have relapsing disease, and no maintenance treatment study has been performed. We evaluated the efficacy of a probiotic preparation (VSL#3) containing 5 x 10(11) per gram of viable lyophilized bacteria of 4 strains of lactobacilli, 3 strains of bifidobacteria, and 1 strain of Streptococcus salivarius subsp. thermophilus compared with placebo in maintenance of remission of chronic pouchitis. METHODS Forty patients in clinical and endoscopic remission were randomized to receive either VSL#3, 6 g/day, or an identical placebo for 9 months. Patients were assessed clinically every month and endoscopically and histologically every 2 months or in the case of a relapse. Fecal samples were collected for stool culture before and after antibiotic treatment and each month during maintenance treatment. RESULTS Three patients (15%) in the VSL#3 group had relapses within the 9-month follow-up period, compared with 20 (100%) in the placebo group (P < 0.001). Fecal concentration of lactobacilli, bifidobacteria, and S. thermophilus increased significantly from baseline levels only in the VSL#3-treated group (P < 0.01). CONCLUSIONS These results suggest that oral administration of this new probiotic preparation is effective in preventing flare-ups of chronic pouchitis.
A Distinct Triplex DNA Unwinding Activity of ChlR1 Helicase*

Background: DNA triplex helix structures are alternate DNA structures that can be a source of genomic instability. Results: ChlR1 helicase has a novel and distinct triplex DNA unwinding activity. Conclusion: ChlR1 defends genome integrity by resolving triplex DNA structures. Significance: The processing of triplex DNA substrates by proteins such as ChlR1 plays critical roles in genome maintenance. Mutations in the human ChlR1 (DDX11) gene are associated with a unique genetic disorder known as Warsaw breakage syndrome characterized by cellular defects in genome maintenance. The DNA triplex helix structures that form by Hoogsteen or reverse Hoogsteen hydrogen bonding are examples of alternate DNA structures that can be a source of genomic instability. In this study, we have examined the ability of human ChlR1 helicase to destabilize DNA triplexes. Biochemical studies demonstrated that ChlR1 efficiently melted both intermolecular and intramolecular DNA triplex substrates in an ATP-dependent manner. Compared with other substrates such as replication fork and G-quadruplex DNA, triplex DNA was a preferred substrate for ChlR1. Also, compared with FANCJ, a helicase of the same family, the triplex resolving activity of ChlR1 is unique. On the other hand, the mutant protein from a Warsaw breakage syndrome patient failed to unwind these triplexes. A previously characterized triplex DNA-specific antibody (Jel 466) bound triplex DNA structures and inhibited ChlR1 unwinding activity. Moreover, cellular assays demonstrated that there were increased triplex DNA content and double-stranded breaks in ChlR1-depleted cells, but not in FANCJ−/− cells, when cells were treated with a triplex stabilizing compound benzoquinoquinoxaline, suggesting that ChlR1 melting of triple-helix structures is distinctive and physiologically important to defend genome integrity. On the basis of our results, we conclude that the abundance of ChlR1 known to exist in vivo is likely to be a strong deterrent to the stability of triplexes that can potentially form in the human genome.
Benefits of the Nonfasting Ketogenic Diet Compared With the Initial Fasting Ketogenic Diet

Objective. The ketogenic diet (KD) is traditionally introduced with an initial period of fasting and fluid restriction that is difficult and sometimes complicated by moderate dehydration. This investigation compares the efficacy and tolerability of the nonfasting ketogenic diet (NFKD) and the conventional initial-fasting ketogenic diet (IFKD). Methods. Forty-one children with intractable epilepsy were treated with the NFKD, beginning with a gradual increase in calories with no initial fasting or fluid restriction. This NFKD population was compared retrospectively with 83 recent historical control subjects who were treated with the IFKD. Efficacy, tolerability, time until strong ketosis, and occurrence of complications were compared. Results. Fourteen (34.1%) patients became seizure-free for at least 3 months after the NFKD, compared with 29 (34.9%) after the IFKD. There was no significant difference in days until strong urinary ketosis between the 2 groups. The incidence of hypoglycemia was also not significantly different between the groups as most other laboratory findings, although the blood urea nitrogen was elevated in 24.1% of the IFKD group and in only 12.2% of the NFKD patients without statistical significance. Conversely, moderate dehydration was significantly less frequent in the NFKD group (12.2%) than in the IFKD group (62.7%). Finally, these results were reflected to the shortening of the hospitalization period in the NFKD group. Conclusions. These observations suggest that initial fasting and fluid restriction are not essential for the KD and that the tolerability of this treatment may be improved. These data support our intention to conduct a formal, prospective, randomized trial comparing 2 forms of the KD.
Board Independence, Audit Quality and Earnings Management: Evidence from Egypt

Using a unique dataset for Egyptian firms, we investigate the relationship between board independence, audit quality and earnings management. We test whether firm-level corporate governance provisions matter in an emerging market setting characterised by weak legal enforcement and inadequate external discipline by the market for corporate control. Our results cast doubt on the notion that a higher ratio of non-executive members is associated with lower earnings management. We find that the effect of board independence on earnings management practices is contingent on the levels of ownership held by executive directors and large shareholders, as well as the composition of audit committee. In addition, the results are consistent with the view that high-quality auditors are effective in reducing earnings management. JEL Classification: M41, M48
Intrathoracic and venous pressure relationships during responses to changes in body position.

Simultaneous end-expiratory pressures, referred to midthoracic level, in the superior and abdominal venae cavae, pericardial space, and right and left heart, were recorded without thoracotomy in three anesthetized dogs during sudden changes from supine to vertical head-up or head-down body positions. Intrathoracic and dependent great vein pressures referred to midchest level (sixth thoracic vertebra) decreased and showed simple hydrostatic gradients in either vertical position. However, a discontinuity in the large vein hydrostatic gradient occurred just distal to the superior margin of the thorax in either body position and was resumed again above this level. It is concluded that, just as the cerebrospinal fluid and intraperitoneal pressures minimize the effects of gravitational and inertial forces on the cerebral and visceral circulations, the pericardial and pleural pressures have a similar role for the heart proper.
Corporate Investment Behaviour in India During 1998–2012

The study of the determinants of the capital structure of Indian firms assumes significance since it deals with the pattern of financing of corporate investments. Over the last 15 years, the Indian economy experienced three different phases of economic growth, viz. 1998–2002, 2003–2007 and 2008–2012. Our study shows that firms relied more on debt financing during the bear phase of 1998–2002 but shifted towards increased equity financing in the bullish period of 2003–2007. The leverage of firms in a year declined in response to increased profit of the earlier year and this behaviour implied debt aversion. The increased financing of investments by corporate savings during 2003–2007 boosted up India’s growth rate. The post-meltdown period of 2008–2012, however, witnessed fall in corporate savings and investments and the accumulation of excess speculative liquidity.
Assessing reproductive profiles in female brown mouse lemurs (Microcebus rufus) from Ranomafana National Park, southeast Madagascar, using fecal hormone analysis

Studies on reproductive endocrinology in wild primate populations have greatly increased in the last decades owing to the development of noninvasive techniques that can be applied under field conditions. However, small‐bodied nocturnal species are not well represented on the long list of primates surveyed in the wild, and reproductive inferences regarding these animals in their natural habitats have not benefited from direct observations of hormonal changes. We collected fecal samples from female brown mouse lemurs (Microcebus rufus) in a southeastern rainforest of Madagascar in order to determine whether or not fecally excreted steroid levels show a consistent pattern of change during the reproductive season and are a useful complement to reproductive observations in wild‐trapped individuals. Initial data show variation in reproductive hormone levels before and after estrus and estimated day of parturition. Elevated levels of excreted estradiol (E2) were observed around the time of estrus, whereas high levels of fecal progesterone (P) were seen during later stages of pregnancy and around parturition. A more complete picture of reproductive profiles in female mouse lemurs, and how they may change over the life span, can be obtained if hormone analyses are used to supplement field observations. Am. J. Primatol. 71:439–446, 2009. © 2009 Wiley‐Liss, Inc.
Voting Cues in Low-Information Elections: Candidate Gender as a Social Information Variable in Contemporary United States Elections

Theory: Theories of low-information voting are used to examine the effect of candidate demographic characteristics on voting behavior, specifically candidate gender. Hypotheses: For voters in low-information elections, candidate gender operates as a social information cue signaling that women candidates are more liberal than men candidates of the same party. As a result, the gender of a candidate affects ideological voting. Method: Logistic regression analysis is performed on data from the 1986 through 1994 American National Election Studies. Results: Women Democratic candidates fare better than men Democratic candidates among more liberal voters and worse among conservative voters, especially those with minimal knowledge of the candidates. The effect is less clear with Republican women candidates who provide conflicting informational cues (woman and Republican).
Dim Sum Bonds: Do They Whet Your Appetite?

In this article, the authors use the Sharpe ratio and stochastic dominance to evaluate and compare the performance of dim sum bond index returns with equity and fixed-income benchmarks in Asia, Europe, and the U.S. The results indicate that dim sum bonds outperform almost all of the benchmarks studied, suggesting dim sum bonds to be a potential candidate for global portfolios.
Long-term outcome of patients with intraspinal neuroblastoma.

BACKGROUND Chemotherapy, radiotherapy, and surgical decompression with laminectomy are effective therapeutic options in the treatment of cord compression from neuroblastoma (NB). We report the long-term outcome of patients with intraspinal NB treated with or without laminectomy at two large pediatric oncology centers. PROCEDURE We reviewed the medical records and radiographs of 26 children with intraspinal NB treated at Children's Memorial Hospital in Chicago, Illinois, between 1985 and 1994 or at St. Jude Children's Research Hospital in Memphis, Tennessee, between 1967 and 1992. RESULTS Twenty-four of the 26 patients are alive and disease-free (follow-up of 2-29 years; median, 10 years 2 months). Fifteen of the 23 patients with neurologic impairment underwent initial laminectomy. Nine of these 15 patients recovered neurologic function, including 3 patients who presented with paraplegia. Eleven of the 15 patients who underwent laminectomy have developed mild to severe spinal deformities. Eight patients with neurologic symptoms consequent to cord compression were treated with initial chemotherapy and/or surgery, but did not undergo laminectomy. Three patients with mild to moderate deficits recovered neurologic function. Four of 11 patients with intraspinal NB who did not undergo laminectomy have mild to severe scoliosis. CONCLUSIONS A low incidence of neurologic recovery was seen in patients with long-standing severe cord compression regardless of treatment modality. For patients with partial neurologic deficits, recovery was seen in most patients following chemotherapy or surgical decompression with laminectomy. A higher incidence of spinal deformities was seen in the patients treated with initial laminectomy.
Distribution of organobrominated and organochlorinated contaminants in Belgian human adipose tissue.

We have measured the levels of flame retardants, polybrominated diphenyl ethers (PBDEs), in 20 recent human adipose tissues from Belgium and compared them to other organohalogen compounds such as polychlorinated biphenyls (PCBs), hexachlorobenzene, 2,2-bis(4-chlorophenyl)-1,1,1-trichloroethane (p,p'-DDT), and its metabolite, 2,2-bis(4-chlorophenyl)-1,1-dichloroethylene (p,p'-DDE). After Soxhlet extraction and cleanup on acidified silica solid-phase extraction cartridges, analysis was achieved by capillary gas chromatography/electron impact mass spectrometry. The method allowed the determination of 5 PBDE and 35 PCB congeners. Concentrations of PBDEs (sum of congeners IUPAC Nos. 28, 47, 99, 100, and 153) ranged between 2.2 and 11.7 ng/g lipid weight and were on the lower end of reported PBDE concentrations in European countries. The median value for the sum of PCBs (35 congeners) was 841 ng/g lipid weight and ranged from 286 to 1802 ng/g lipid weight. The median value for the sum of DDTs (calculated from p,p'-DDE and p,p'-DDT) was 290 ng/g lipid weight and ranged from 47 to 2802 ng/g lipid weight. The sum of PCBs showed a good correlation with the sum of DDTs (r=0.77, P<0.05), while the correlation with the sum of PBDEs was weaker (r=0.56, P<0.05). No age dependency was found for PBDEs (r=0.09), while PCBs and DDTs showed higher correlation coefficients with age (r=0.59 and 0.40, respectively, P<0.05).
Behavioural Response: Still a Major Concern for AVCSS?

With the recent advances made in AVCSS (Advanced Vehicle Control and Safely Systems), designed to aid the driver and in some cases replace driver functions, it has become apparent that many of the technological barriers facing these systems are (or soon will be) soluble. Comparatively little attention would seem to have been given however as to how the driver will interact with these systems, with issues such as driver behavioural shifts and even system desirability receiving little study. This article reviews exactly how far investigation into these problems has progressed for some of the most high profile systems. It is concluded that although many systems are now viewed positively by the driving public, and may soon be within their reach, the introduction of automation needs to be carefully managed. Indeed, although some systems are sufficiently advanced as to be market-ready, many on-going issues still exist that may impede deployment.
Multiresolution analysis of pathological changes in cerebral venous dynamics in newborn mice with intracranial hemorrhage: adrenorelated vasorelaxation

Intracranial hemorrhage (ICH) is the major problem of modern neonatal intensive care. Abnormalities of cerebral venous blood flow (CVBF) can play a crucial role in the development of ICH in infants. The mechanisms underlying these pathological processes remain unclear; however it has been established that the activation of the adrenorelated vasorelaxation can be an important reason. Aiming to reach a better understanding of how the adrenodependent relaxation of cerebral veins contributes to the development of ICH in newborns, we study here the effects of pharmacological stimulation of adrenorelated dilation of the sagittal sinus by isoproterenol on the cerebral venous hemodynamics. Our study is performed in newborn mice at different stages of ICH using the laser speckle contrast imaging and wavelet analysis of the vascular dynamics of CVBF. We show that the dilation of the sagittal sinus with the decreased velocity of blood flow presides to the stress-induced ICH in newborn mice. These morphofunctional vascular changes are accompanied by an increased variance of the wavelet-coefficients in the areas of endothelial and non-endothelial (KATP-channels activity of vascular muscle) sympathetic components of the CVBF variability. Changes in the cerebral venous hemodynamics at the latent stage of ICH are associated with a high responsiveness of the sagittal sinus to isoproterenol quantifying by wavelet-coefficients related to a very slow region of the frequency domain. The obtained results certify that a high activation of the adrenergic-related vasodilatory responses to severe stress in newborn mice can be one of the important mechanisms underlying the development of ICH. Thus, the venous insufficiency with the decreased blood outflow from the brain associated with changes in the endothelial and the sympathetic components of CVBF-variability can be treated as prognostic criteria for the risk of ICH during the first days after birth.
Domestic market integration and the law of one price in Brazil

ABSTRACT This article presents the first assessment of domestic market integration in Brazil using the law of one price. The law of one price is tested using two panel unit root methodologies and a unique data set comprising price indices for 51 products across 11 metro-areas. We find that the law holds for most tradable products and, not surprisingly, nontradable products are found to be less likely to satisfy the law of one price. While these findings are consistent with evidence found for other countries, price convergence occurs very slowly in Brazil, suggesting relatively limited domestic market integration.
Effects of Knee Pain Relief in Osteoarthritis on Gait and Stair-Stepping

Osteoarthritic knee pain affects patient mobility. Relief of knee pain in osteoarthritis has been reported to increase loading of the knee during gait, but it is unknown whether such pain relief enhances knee loading during more demanding activities such as stair-stepping. The gait of 19 patients and stair-stepping of 14 patients with painful medial compartment osteoarthritis of the knee was assessed before and after pain-relieving intraarticular injection of the knee and compared with those of 21 healthy control subjects. There were significant increases in gait velocity, cadence, maximum external knee adduction moment (indicating increased loading in the medial compartment of the knee), and maximum external hip adduction and ankle abduction moments immediately after the injection. With the exception of velocity and ankle abduction moment, these variables were returned to levels that were not statistically different from those of the control subjects. However, no significant differences were found during stair-stepping in the external adduction-abduction moments about the knee, hip, or ankle after injection. Furthermore, the postinjection magnitudes of these variables during stair-stepping were significantly less than those of the controls. Therefore, although the relief of knee pain is sufficient to enhance gait function in osteoarthritis of the knee, it is insufficient to enhance stair-stepping function.
Transplantation of human adipose tissue-derived stem cells for repair of injured spiral ganglion neurons in deaf guinea pigs

Excessive noise, ototoxic drugs, infections, autoimmune diseases, and aging can cause loss of spiral ganglion neurons, leading to permanent sensorineural hearing loss in mammals. Stem cells have been confirmed to be able to differentiate into spiral ganglion neurons. Little has been reported on adipose tissue-derived stem cells (ADSCs) for repair of injured spiral ganglion neurons. In this study, we hypothesized that transplantation of neural induced-human ADSCs (NI-hADSCs) can repair the injured spiral ganglion neurons in guinea pigs with neomycin-induced sensorineural hearing loss. NI-hADSCs were induced with culture medium containing basic fibroblast growth factor and forskolin and then injected to the injured cochleae. Guinea pigs that received injection of Hanks′ balanced salt solution into the cochleae were used as controls. Hematoxylin-eosin staining showed that at 8 weeks after cell transplantation, the number of surviving spiral ganglion neurons in the cell transplantation group was significantly increased than that in the control group. Also at 8 weeks after cell transplantation, immunohistochemical staining showed that a greater number of NI-hADSCs in the spiral ganglions were detected in the cell transplantation group than in the control group, and these NI-hADSCs expressed neuronal markers neurofilament protein and microtubule-associated protein 2. Within 8 weeks after cell transplantation, the guinea pigs in the cell transplantation group had a gradually decreased auditory brainstem response threshold, while those in the control group had almost no response to 80 dB of clicks or pure tone burst. These findings suggest that a large amount of NI-hADSCs migrated to the spiral ganglions, survived for a period of time, repaired the injured spiral ganglion cells, and thereby contributed to the recovery of sensorineural hearing loss in guinea pigs.