Miracle-dz/UniFAR-FTUs huggingface dataset:
2 Adjuvant Therapy for Resectable Colorectal Cancer Liver Metastases Yukihide Kanemitsu

The most effective treatment for liver metastases from colorectal cancer is surgical resection. When curative resection is possible, a 5-year survival rate of 25% to 58% can be expected; the mortality rate associated with surgery is as low as 1% to 5% (Adson et al., 1984; Huges et al., 1986; Scheele et al., 1995; Nordlinger et al., 1996; Jamison et al., 1997; Iwatsuki et al., 1999; Fong et al., 1999; Minagawa et al., 2000; Figueras et al., 2001; Choti et al., 2002; Kato et al., 2003; Abdalla et al., 2004; Fernandez et al., 2004; Wei et al., 2006; Rees et al., 2008) (Table 1). Surgical procedures are improving for liver resection. In cases with synchronous liver metastases, resection of primary colorectal cancer with lymph node dissection and liver resection were indicated if tumors would be completely removed surgically. In cases with metachronous liver metastases, the indication for liver resection was the same as synchronous liver metastases if extrahepatic metastases were not detected. More recently, experience has demonstrated that patients with the traditional adverse factors can experience long-term survival following liver resection (Minagawa et al., 2000; Elias et al., 2003). Thus, a shift has occurred in the criteria used for assessing resectability, from morphologic criteria to new ones based on whether a macroscopically and microscopically complete resection of the liver can be achieved. These advancements were reported to improve the resectability and survivals of patients. Although evidence from cohort studies or randomized controlled trials are not available to support this conclusion, cases of longterm survival are almost nonexistent among patients who were eligible for surgical resection of liver metastases but did not undergo the procedure. Outcomes after hepatectomy are so good that studies comparing this treatment with other treatments may be difficult to accept. Despite this, recurrence is common after resection of liver metastases. Recurrence in the remaining liver occurs with a frequency of 50% to 60%, followed by lung metastasis at 20% to 30%, and they occur within the first 2 years after surgery. Based on these observations, liver metastasis can be thought of as a local or systemic disease. Thus, improving prognosis after resection of liver metastases likely involves controlling local recurrence (in the remaining liver) and extrahepatic metastases (primarily lung metastases). However, few clinical trials have focused on cases of colorectal cancer after hepatic resection; no adjuvant chemotherapy has yet been proven effective in this context.
Ventilator-associated Sinusitis: Microbiological Results of Sinus Aspirates in Patients on Antibiotics

BackgroundThe efficacy of systemic antibiotics on the treatment of ventilator-associated infectious maxillary sinusitis (VAIMS) is debated. The objective of this study was to determine the etiologic diagnosis of VAIMS in patients receiving antibiotics. MethodsPatients mechanically ventilated for more than or equal to 72 h, who had persistent fever while on antibiotics for more than or equal to 48 h, underwent computed tomography scan followed by transnasal puncture of involved maxillary sinuses. VAIMS was defined as follows: fever greater than or equal to 38°C, radiographic signs (air fluid level or opacification of maxillary sinuses on computed tomography scan), and a quantitative culture of sinus aspirate yielding more than or equal to 103 colony-forming units/ml. ResultsTwenty-four patients had radiographic signs of sinusitis. The mean ± SD prior durations of mechanical ventilation and antibiotic exposure were 9.5 ± 4.7 days and 6 ± 4 days, respectively. Six unilateral and nine bilateral VAIMS were diagnosed in 15 patients. The median number of etiologic organisms per patient was two (range, one to four). The bacteriologic cultures yielded gram-positive bacteria (n = 21), gram-negative bacteria (n = 22), and yeasts (n = 5). Forty percent of causative agents were susceptible to the antibiotics prescribed. Seven patients with VAIMS developed 10 concomitant infections: ventilator-associated pneumonia (n = 5), urinary tract infection (n = 3), catheter infections (n = 2). In all cases of ventilator-associated pneumonia, the implicated agents were the causative agents of VAIMS. ConclusionIn VAIMS patients on antibiotics, quantitative cultures of sinus aspirates may contribute to establish the diagnosis. The frequent recovery of microorganisms susceptible to the antimicrobial treatment administered suggests that therapy of VAIMS with systemic antibiotics may not be sufficient.
Phage display and bacterial expression of a recombinant Fab specific for Pseudomonas aeruginosa serotype O6 lipopolysaccharide

Immunotherapy with antibodies (Abs) against the lipopolysaccharide (LPS) of Pseudomonas aeruginosa remains an alternative to serotype-specific LPS-based vaccines due to their limited use and to antibiotics due to the intrinsic resistance to antimicrobials observed in P. aeruginosa. We have chosen a monoclonal Ab (MAb), MF23-1, that binds to the O antigen of the most clinically relevant serotype, IATS O6, for producing a recombinant antibody. Heavy (H) and light (L) chain genes were isolated from MF23-1 to form a functional Fab molecule in the periplasm of Escherichia coli and on the surface of phage by using phagemid vector pComb3. The entire kappa L chain gene was used, but the H chain gene was amplified to 2 amino acids past cysteine 128 which is involved in interchain disulfide bond formation with the L chain. The truncated H chain associated with the L chain in the periplasm of E. coli to form a functional Fab molecule that bound in both enzyme-linked immunosorbent assay (ELISA) and immunofluorescence assay to O6 LPS. Therefore, the remainder of the CH1 past cysteine 128 is not essential for stable formation of the Fab portion of MF23-1. This recombinant Fab (r-Fab) was shown to be specific for the LPS of the most predominant clinical isolate, serotype O6, while no cross-reactivity was detected to the LPS of the other 19 remaining serotypes. This r-Fab was also expressed on the surface of filamentous phage upon addition of helper phage to recombinant E. coli containing phagemid. Recombinant phage from clones MT13 and MT24 bound specifically to O6 LPS in ELISA. These results represent an important step toward the design of therapeutic Abs to be used against P. aeruginosa infections.
Role of anaerobic flora in the translocation of aerobic and facultatively anaerobic intestinal bacteria

It is thought that the normal enteric microflora acts not only to prevent intestinal colonization but also to prevent subsequent systemic dissemination of ingested, potentially pathogenic bacteria. To determine the relative roles of specific components of the intestinal bacterial flora in bacterial translocation out of the gut, mice were given various antimicrobial agents to selectively eliminate specific groups of intestinal bacteria. The cecal flora and the translocating bacteria in mesenteric lymph nodes were monitored both before and after oral inoculation with antibiotic-resistant Escherichia coli C25. Orally administered streptomycin selectively eliminated cecal facultative gram-negative bacilli, orally administered bacitracin-streptomycin eliminated all cecal bacterial species except low numbers of aerobic sporeformers, and parenterally administered metronidazole selectively eliminated cecal anaerobic bacteria. Compared with control mice, only metronidazole-treated mice had significantly increased rates of dissemination of intestinal bacteria into mesenteric lymph nodes, indicating that the exclusive absence of anaerobic bacteria facilitated the translocation of the intestinal facultative bacteria. In a parallel experiment with streptomycin-resistant E. coli C25 as a marker, parallel results were obtained. Metronidazole increased the translocation of the marker strain and the indigenous strains of intestinal bacteria. Thus, anaerobes appeared to play a key role in confining indigenous bacteria to the gut. However, intestinal colonization and translocation of E. coli C25 occurred most readily after bacitracin-streptomycin treatment, suggesting that in addition to anaerobic bacteria, other bacterial groups may play a role in limiting the intestinal colonization and extraintestinal dissemination of E. coli C25.
Applications of twitter emotion detection for stock market prediction

Currently, most applications of sentiment analysis focus on detecting sentiment polarity, which is whether a piece of text can be classified as positive or negative. However, it can sometimes be important to be able to distinguish between distinct emotions as opposed to just the polarity. In this thesis, we use a supervised learning approach to develop an emotion classifier for the six Ekman emotions: joy, fear, sadness, disgust, surprise, and anger. Then we apply our emotion classifier to tweets from the 2016 presidential election and financial tweets labeled with Twitter cashtags and evaluate the effectiveness of using finer-grained emotion categorization to predict future stock market performance. Thesis Supervisor: Andrew W. Lo Title: Charles E. and Susan T. Harris Professor
The Liturgical Cope of D. Teotónio of Braganza: Material Characterization of a 16th Century Pluviale

Abstract A 16th century liturgical cope belonging to D. Teotónio of Braganza (collection of the Museum of Évora, ME 172/1) was selected for a material study. The cope is made of a variety of materials that include two different types of metal threads, dyed silk yarns, and vegetable yarns used in the weft. Several samples from different points representing the different metal thread types and colored silk yarns were collected. Stereomicroscopy (optical microscopy) and scanning electron microscopy were used for morphological analysis of the textile fibers and evaluation of metal thread degradation products. Evaluation of mordants and metal thread composition was carried out by energy-dispersive X-ray spectroscopy. Liquid chromatography with diode array and mass spectrometry detection was used for dye identification, which allowed the determination of three different red dye sources and one yellow dye source in the colored silk yarns. Although different fabrics were used in the manufacturing of the cope, similarities identified in the characterization of the materials suggest that a single workshop was involved in its making.
The Value Relevance of Goodwill: IFRSs and Global Financial Crisis (GFC)

This study contributes to the issue of accounting for goodwill by examining the impact of changing from the Australian Generally Accepted Accounting Principles (AGAAP) to Australian International Financial Reporting Standards (AIFRS) on goodwill, 3 years (2002 to 2004) before and 3 years (2006 to 2008) after AIFRS adoption. The sample is drawn from top 200 companies listed on the Australian Stock Exchange (ASX). This study applies multiple regressions. The dependent variable is the closing share price 3 months after the balance sheet date. The independent variables consist of earnings per share, book value per share, goodwill in the balance sheet, goodwill in the income statement (goodwill amortisation and goodwill impairment) and goodwill acquisition. The findings indicate that goodwill accounted for in the income statement and balance sheet do not provide increased explanatory power of market value under AIFRS compared to AGAAP. Moreover, the goodwill in the income statement does not show value relevance in year 2007, but became significant in year 2008 during the global financial crisis (GFC). Also, the age of goodwill recorded in the balance sheet does not affect the value relevance of earnings and book value in the post-adoption period. This study contributes new evidence on accounting for goodwill under pre and post-IFRS accounting regimes in Australia. This is also the first study to examine the separate effects of goodwill accounting on earnings and net assets, with special attention given to the period before and during the GFC in capital markets.
Influences of end-point heating temperature on the quality attributes of chicken meat

ABSTRACT This study aimed to evaluate the changes in physicochemical, textural and sensory characteristics of broiler (BR) and Taiwan native chicken (TNC) pectoralis muscle heated at temperatures of 50–95°C. With increasing temperature, cooking loss, collagen solubility, shear force value and hardness, of samples increased in both chicken breeds. Rapid decreases in protein solubility were observed when the meat was heated to 50°C and gradually decreased thereafter. Meat from BRs and native chickens performed differently upon heating in certain characteristics. TNC meat had longer cooking time and lower myofibrillar fragmentation index than BR meat did. TNC meat had higher collagen content, shear force values and springiness but lower collagen solubility than BR meat did. BR meat had significantly higher onset and end transition temperatures than TNC meat did. In BR meat, a sensory analysis revealed that moisture release decreased and chicken flavour increased with increasing temperature. Protein solubility, cooking loss and the texture of heated meat were highly correlated. This study scientifically assessed the performances of the two breeds of chickens with different thermal treatments; producers could utilise the information to produce poultry products with more desirable qualities.
Study of sense of coherence health promoting behavior in north Indian students

Background & objectives: With advances in knowledge about health promotion, public health professionals are in search for the determinants of personal health behaviours. This study was carried out to explore the level of engagement of north Indian students in health promoting behaviours; to determine their sense of coherence scores; and to ascertain the determinants of health promoting behaviours of these students. Methods: A cross-sectional study was done in four randomly selected colleges of Chandigarh during 2007-2008 in 200 students (100 male, 100 female). Their health promoting lifestyle profile (HPLP) and sense of coherence (SOC) scores were estimated using interviews. The data were analyzed using Pearson's product moment correlation, and also stepwise linear regression analysis. Results: Mean HPLP and SOC scores of the students were 138.69 and 130.87, respectively. Females cared more about their health than males. Male students were more involved in physical activities. There was a linear correlation between the total SOC and HPLP scores (r=0.3). Female students (63%) consulted doctors more than males (50%) and washed their hands more regularly (P<0.05). Only 13 per cent students practiced yoga regularly. Female students had more meaningful relationships with friends and had more faith in God. Regression equation revealed that the two independent variables (SOC and age) accounted for 10.8 per cent of the variance in HPLP. Interpretation & conclusion: Students with higher SOC scores had higher HPLP scores. Female students were more health conscious than male students. In general, college students in Chandigarh had a good health promoting lifestyle and good sense of coherence.
EFFECT OF WEBSITE QUALITY, CUSTOMER EMOTION AND ELECTRONIC CUSTOMER SATISFACTION ON ELECTRONIC LOYALTY OF CUSTOMER IN TRIP RESERVATION WEBSITES

Abstract. The present study is aimed to evaluate the impact of website quality, customer emotion and electronic customer satisfaction on electronic loyalty of customer. The present study is an applied study based on purpose and it is a survey-descriptive in terms of data collection. The study population is the customers of websites of online reservation of travel agencies. By convenient sampling, 367 customers were selected. In the present study, to test the measurement model and study hypotheses, structural equations modeling by the partial least squares using SMARTPLS software is applied. The results showed that the impact of website quality, customer emotion and electronic satisfaction of customer on electronic loyalty of customer was positive and significant. The impact of customer emotion and website quality on electronic satisfaction of customer was positive and significant. The impact of website quality on customer emotion was positive and significant. Totally, the results emphasized the role of quality of website, customer emotion and satisfaction of electronic customer on electronic loyalty of customer. Keywords: Website quality, Customer emotion, Electronic customer satisfaction, Customer electronic loyalty.
Adjacent segment disease perspective and review of the literature.

BACKGROUND Adjacent segment disease has become a common topic in spine surgery circles because of the significant increase in fusion surgery in recent years and the development of motion preservation technologies that theoretically should lead to a decrease in this pathology. The purpose of this review is to organize the evidence available in the current literature on this subject. METHODS FOR THIS LITERATURE REVIEW, A SEARCH WAS CONDUCTED IN PUBMED WITH THE FOLLOWING KEYWORDS: adjacent segment degeneration and disease. Selection, review, and analysis of the literature were completed according to level of evidence. RESULTS The PubMed search identified 850 articles, from which 41 articles were selected and reviewed. The incidence of adjacent segment disease in the cervical spine is close to 3% without a significant statistical difference between surgical techniques (fusion vs arthroplasty). Authors report the incidence of adjacent segment disease in the lumbar spine to range from 2% to 14%. Damage to the posterior ligamentous complex and sagittal imbalances are important risk factors for both degeneration and disease. CONCLUSION Insufficient evidence exists at this point to support the idea that total disc arthroplasty is superior to fusion procedures in minimizing the incidence of adjacent segment disease. The etiology is most likely multifactorial but it is becoming abundantly clear that adjacent segment disease is not caused by motion segment fusion alone. Fusion plus the presence of abnormal end-fusion alignment appears to be a major factor in creating end-fusion stresses that result in adjacent segment degeneration and subsequent disease. The data presented cast further doubt on previously established rationales for total disc arthroplasty, at least with regard to the effect of total disc arthroplasty on adjacent segment degeneration pathology.
Practical relevance of theory-driven supply chain management research

PurposeThe purpose of this paper is to examine the extent to which theory-driven supply chain management (SCM) research is of practical relevance. It does this on the basis of empirical research in China.Design/methodology/approachA two-pronged approach was adopted. First, 57 theory-driven SCM studies based in China published in ten leading journals between 2006 and 2015 were surveyed. Second, a questionnaire survey of Chinese managers identified their practical concerns and assessed their alignment with the content of the academic papers.FindingsSome academic research on SCM does probe industry-relevant problems. From an academic perspective, this confirms that theory-driven SCM research can be of practical value. Overall, however, the survey found that much of the SCM research works do not translate into actionable knowledge for practitioners. Academic research in this field could pursue a more pragmatic path and enhance its practical utility. Two critical components of this path, “practical observation” and “practical verification,” are highlighted.Research limitations/implicationsAs the literature review was confined to ten leading journals, relevant papers in other journals were possibly excluded. The research was confined to China and so the results are not necessarily generalizable to other countries.Practical implicationsChinese academics and practitioners could collaborate in defining research agendas and directions. This would help researchers direct their theory building to issues of relevance to business.Originality/valueTo the best of the authors’ knowledge, this is the first study to investigate the relevance of theory-driven SCM research from academic and practitioner perspectives in China. It shows how this research might have greater impact on business practice.
Serological Evaluation of HSV-1 and HSV-2 Infection In Pregnancy

Genital HSV infection in pregnant women is of particular importance because of the risk to the fetus and newborn. Data from several prospective trials have shown that the major risk to the fetus results from primary maternal genital HSV infection. Over 95% of infected babies are born to women who are unaware that they have genital herpes. The most severe forms of neonatal disease occur when infection of the mother occurs during the last stage of pregnancy, at a time when maternal antibodies develop much more slowly for Abstract: We performed a serological evaluation of herpes simplex virus (HSV) infections at the time of labor. In order to determine the seroprevalence of asymptomatic HSV infections in pregnant women, blood samples were collected for antibody measurement from 130 randomly selected pregnant women. Presence of HSV IgG and IgM antibodies in the serum samples was tested by ELISA. The prevalence of HSV-1 gG1 antibodies was 90% (117/130), that of HSV-2 gG2 antibodies was 63.1% (82/130) and that of HSV- 2 IgM antibodies was 13.8% (18/130). Eight (44.4%) of the pregnant women with HSV-2 IgM were at the same time found to have HSV-2 IgG antibodies, and 10 (55.6%) women were determined to have HSV-2 IgM antibodies. Furthermore, 6 (4.6%) out of the 130 pregnant women were seronegative for HSV. In conclusion, the results of our study show that the prevalence of HSV-2 infection (63.1%) is relatively high among asymptomatic pregnant women in Adana, Turkey. Therefore, to take precautions for reducing the risk of neonatal herpes, the investigation of HSV-2 type specific antibodies in pregnant women should be offered by using HSV-2 gG2 type specific serological tests that allow the identification of women with asymptomatic or subclinical genital HSV-2 infection and women susceptible to primary genital HSV- 2 infection.
Histological study on effect of mesenchymal stem cell therapy on experimental renal injury induced by ischemia/reperfusion in male albino rat.

BACKGROUND AND OBJECTIVES Acute kidney injury (AKI) represents a major clinical problem with high mortality and limited treatment protocols. This study was planned to evaluate the therapeutic effectiveness of bone marrow - derived mesenchymal stem cells (BM-MSCs) in a rat model of ischemia/reperfusion (I/R) AKI. METHODS AND RESULTS This study was carried out on thirty adult male albino rats. Animals were divided equally into three groups. Group I (control sham-operated group) (n=10), were subdivided equally into two subgroups; Ia and Ib. The experimental group (n=20) were all subjected to I/R injury by clamping both renal pedicles for 40 minutes. Half of the I/R animals did not receive MSC therapy (group II) [non-MSC treated group]. The other half of the I/R animals received single intravenous injection of PKH26 labelled BM-MSCs immediately after removal of the clamps and visual confirmation of reflow (group III) [MSC treated group]. Animals were sacrificed 24 hrs (subgroups IIa & IIIa) and 72 hrs (subgroups IIb & IIIb) after intervention. Serological measurements included serum urea and creatinine. Kidney specimens were processed for H&E, PAS and PCNA. Mean % of renal corpuscles with affected glomeruli, mean % of affected tubules, mean area % of PAS-positive reaction and mean area % of PCNA immunoreactivity were measured by histomorphometric studies and statistically compared. MSCs-treated group exhibited protection against renal injury serologically and histologically. CONCLUSIONS Results of the present study suggest a potential reno-protective capacity of MSCs which could be of considerable therapeutic promise for cell-based management of clinical AKI.