Miracle-dz/UniFAR-FTUs huggingface dataset:
Mortality after endovascular repair of ruptured abdominal aortic aneurysms: a systematic review and meta-analysis.

OBJECTIVE To document mortality after endovascular repair of ruptured abdominal aortic aneurysms (RAAAs). DATA SOURCES MEDLINE and EMBASE databases. STUDY SELECTION Articles that reported data on mortality after endovascular repair of RAAAs were identified. Only patients with true ruptures were included. Additionally, information on mortality after concurrent open repair was sought. DATA EXTRACTION One of the authors reviewed all of the studies and extracted appropriate data. A total of 43 articles were identified, 14 of which were excluded. DATA SYNTHESIS Twenty-nine articles with 897 patients who underwent endovascular repair met the inclusion criteria. Of the patients with available information, 86% were men; 29% had been operated on under local anesthesia; 28% were hemodynamically unstable; 17% required intra-aortic balloon occlusion; 48% received bifurcated stent grafts; 6% had endovascular procedures converted to open repair intraoperatively; and 5.5% developed abdominal compartment syndrome. In-hospital and/or 30-day mortality ranged between 0% and 54% in different series, whereas the pooled mortality after endovascular repair was 24.5% (95% confidence interval [CI], 19.8%-29.4%). In 19 studies reporting results of both endovascular and concurrent open repair from the same unit, the pooled mortality after open repair was 44.4% (95% CI, 40.0%-48.8%), and the pooled overall mortality for RAAA undergoing endovascular or open repair was 35% (95% CI, 30%-41%). CONCLUSIONS Endovascular repair of RAAAs is associated with acceptable mortality rates. Additional studies will be required to verify these promising results and precisely define the role of endovascular treatment as an additional therapeutic option for RAAAs.
A bird's eye view – of a leopard's spots The Çatalhöyük ‘map’ and the development of cartographic representation in prehistory

Abstract The striking wall paintings uncovered in the excavations at Çatalhöyük have fascinated archaeologists and non-archaeologists alike, and many interpretations of their content and meaning have been proposed. This article re-evaluates the claim that one of these paintings is a map of the village, with Hasan Dağ erupting above it. It is argued that the excavator's first interpretation of the objects depicted in the painting, that is, that they are a leopard skin above a panel of geometric design, is in fact a far more reasonable one, when this painting is contextualised within the entire corpus of painting and other art objects found at the site. Implications of this re-interpretation for our understanding of Neolithic spatial and symbolic representation, and the origin of mapmaking are considered, as well as the importance of the depiction of animals and felines in the Neolithic period. Özet Çatalhöyük kazılarında bulunan göz alıcı duvar resimleri hem arkeologları hem de arkeolog olmayanları aynı derecede büyülemiş ve bu resimlerin içerik ve anlamlarına ilişkin birçok yorum yapılmıştır. Bu makalede patlama anındaki Hasan Dağı ile birlikte betimlenen resmin köyün haritası olduğu varsayımı tekrar değerlendirilmektedir. Belirtildiğine göre, kazı başkanının bu resimle ilgili ilk yorumu buradaki nesnelerin geometrik desenli bir panel üzerinde leopar derisini betimlediği yolundadır. Aslında bu yorum, içerik olarak düşünüldüğunde yerleşimdeki diğer tüm resim ve sanatsal nesnelerle daha uyumludur. Bu makalede Neolitik Çağdaki uzamsal ve sembolik betimleme anlayışımıza göre resmin tekrar yorumlanması ve haritacılığın kökeninin yanı sıra bu çağdaki hayvan, özellikle feline betimlemelerinin önemini de tartışılmaktadır.
Comparison satisfaction in athletes of leadership styles in the sport of karate

The aim of this study was comparison satisfaction in athletes of leadership styles in the sport of karate.The research employs descriptive-correlation method.The population of the study, all athletes participating in the 2012 national competition in karate formed two studies (150 patients)from which the sample was taken of all methods Of which 80 were women and 70 were men.This study includes a questionnaire scales measuring leadership in sport (LSS) with reliability 0/90 was used to measure the satisfaction of the athlete satisfaction questionnaire developed by the researchers from the Questionnaire (ASQ) and reliability 0/93 was used. Finally, to analyze the data, descriptive statistics, mean, standard deviation was used. For data analysis, descriptive statistics, mean, standard deviation was used.Women view, Karate of the operating management style, management styles and priorities in education, Karate task-oriented managerial style. The results suggest a close relationship with the players, the coaches, players, issues and problems, technical and tactical guidanceduring competition and training and education to improve the skills of the players' strengths and weaknesses, and special attention should beit also recommended that coaches deal with players in different age groups of behaviors and leadership styles appropriate to use. According to the results of the use of mental skills coaches and management will be more.Classes are offered in these skills should be taught to teachers and the importance of these skills for trainers will tell.
Symptom use and self‐regulation in type II diabetes

A model of self-regulation that explains the health behavior of type II diabetic patients was tested by examining the use of symptoms as indicators of perceived blood glucose levels in 38 outpatients. Results of the study supported the self-regulation model by demonstrating that patients use symptoms to monitor blood glucose levels and to guide diabetes-related actions. Implications of the model for planning interventions with type II diabetes are discussed.
5HT1A and 5HT2A receptor genes in treatment response phenotypes in major depressive disorder

The 5HT2A (5HTR2A) and 5HT1A receptor (5HTR1A) genes are plausible candidate genes for major depressive disorders. Two single nucleotide polymorphisms, the rs7997012 in 5HTR2A and the –1019C/G in 5HTR1A, were analyzed in 206 patients with Diagnostic and Statistical Manual of Mental Disorders, fourth edition major depressive disorder. Patients were retrospectively characterized for clinical response to antidepressant treatment. We found a significant difference in the rs7997012 allele frequency between resistant and nonresistant patients. However, following the Bonferroni correction we could not find any association between this single nucleotide polymorphism and treatment resistance phenotype. Nevertheless, given the limited power of our analysis, we are not able to conclude that these results reflect a lack of association. Additional studies are needed to confirm or to disprove our result.
Histochemical Demonstration of Two Subtypes of O‐linked Oligosaccharides in the Rat Gastric Glands

The gastric glands synthesize glycoproteins whose oligosaccharides are linked to the peptide core mainly by the O‐glycosidic bond, specifically removed by β‐elimination procedure. Our aim was to research the possibility of the existence of two subtypes of O‐linked oligosaccharides with a different behavior to the removal procedure. The lectins from peanut (PNA) and Maackia amurensis (MAA‐I) were histochemically used as markers of the O‐linked oligosaccharides. Sections were also pretreated with β‐elimination and/or peptide N‐Glycosidase F (PNGase‐F) for the specific removal of O‐ and N‐linked oligosaccharides, respectively. The lectin GNA, which mainly labels to N‐linked oligosaccharides, was used to test the correct working of PNGase‐F. To test the possibility that the β‐elimination treatment could remove the terminal sialic acid residues, the lectin LFA was used. The surface epithelium was negative to PNA, while it became strongly positive when β‐elimination was performed for 1 day. This staining was resistant to PNGase‐F, suggesting that PNA was labeling to O‐linked oligosaccharides. However, after β‐elimination for 5 days this staining is not observed. A similar pattern appeared with MAA‐I. We propose the existence of two subtypes of O‐linked oligosaccharides: labile and resistant. The labile O‐linked oligosaccharides are removed with β‐elimination for 1 day, unmasking the PNA‐positive oligosaccharides. These oligosaccharides are resistant O‐linked oligosaccharides because staining is abolished with longer treatment of β‐elimination. The results with MAA‐I also support this suggestion. In summary, the labile O‐linked oligosaccharides are removed with short treatment, while the resistant O‐linked oligosaccharides need a stronger procedure (for 5 days). Microsc. Res. Tech., 2007. © 2007 Wiley‐Liss, Inc.
Phase II Study of Gemcitabine and Cisplatin in Patients with Previously Untreated Extensive Stage Small Cell Lung Cancer: Southwest Oncology Group Study 9718

Background: This phase II study (S9718) evaluated the antineoplastic activity and tolerability of the combination of gemcitabine and cisplatin in previously untreated patients with extensive stage small cell lung cancer (ES-SCLC). Methods: Chemonaive patients with ES-SCLC, received gemcitabine 1250 mg/m2 intravenously (IV) over 30 minutes on days 1 and 8 and cisplatin 75 mg/m2 IV over 30 to 60 minutes on day 1. Treatments were repeated every 21 days for a maximum of six cycles. Results: A total of 88 patients were enrolled in the study; seven patients were not eligible and one did not receive treatment; 80 patients were fully assessable for survival, response, and toxicity. Objective response was observed in 42 patients (53%; 95% confidence interval [CI]: 41%–64%) with two patients (3%; 95% CI: 0%–8%) achieving a complete response. Median PFS was 5 months (CI, 4.2-5.9 months), and median overall survival was 8.8 months (95% CI: 7.8–9.5 months). The 1- and 2-year survival rates were 27.5% (95% CI: 17.7%–37.3%) and 4% (95% CI: 0%–8%), respectively. The most common toxicity was neutropenia. Grade 3 and 4 neutropenia was noted in 17 (21%) and 17 (21%) patients, respectively. Two patients developed febrile neutropenia, with subsequent full recovery. Twenty-one patients (23%) developed grade 3 thrombocytopenia. Grade 4 thrombocytopenia was seen in only one patient. The most common nonhematologic toxicities included grade 3 and 4 vomiting in 12 (21%) patients and fatigue in nine (10%) patients. Two patients (3%) died of respiratory infections while on treatment. Conclusion: The combination of gemcitabine and cisplatin is an active and reasonably well tolerated regimen for the treatment of ES-SCLC. It does not appear to offer any compelling advantages over other commonly used two drug regimens in this disease.
The Effect of Social Disclosure on the Intensity of Affect Provoked by Autobiographical Memories

Affect associated with negative autobiographical memories fades faster over time than affect associated with positive autobiographical memories (the fading affect bias). Data described in the present article suggest that this bias is observed when people use their own words to describe both the emotions that they originally felt in response to events in their lives and the emotions that they feel when they recall those events. The data also suggest that the fading affect bias is not a consequence of distortion in memory for the emotions experienced at event occurrence, but instead reflects current affective responses to memories for those events. Moreover, this bias has a social component. Frequently disclosed memories evince a stronger fading affect bias than less frequently disclosed memories. Memories disclosed to many types of people evince a stronger fading affect bias than memories disclosed to few types of people. Finally, the relation between social disclosure and fading affect appears to be causal: the results of an experiment demonstrate that social disclosure decreases the fading of pleasant affect and increases the fading of unpleasant affect associated with autobiographical memories.
Scrapie: a review of its relation to human disease and ageing.

Scrapie is a naturally occurring disease of sheep which has been recognized in England for nearly 250 years (McGowan, 1914). Indeed as early as 1755 the farmers of Boston (Lincs.) petitioned the House of Commons on account of the economic losses it caused, and sought that 'distempered' animals be restrained from mixing with healthy ones (Palmer, 1959). On the Continent, the disease (under a variety of names-'la tremblante', 'Prurigo lombaire', 'maladie chancelante', 'nevraxite enzootique du mouton', 'Zitternkrankheit', 'Traberkrankheit' (trotting disease), 'Grubberkrankheit' (nibbling disease), 'Reiberkrankheit' (rubbing disease)) was also rampant. Stockman (1913) has reviewed the contentious points in the history of the disease and records the first use of the term scrapie in 1853. It is commonly said to have been imported into this country with merino sheep from Spain, but isolated outbreaks have occurred in recent times (Palmer, 1959), e.g. in North America and Australia (Bull and Murnane, 1958) and even the remote Himalayan foothills are not immune, though the disease there seems to have been recognized for less than a quarter of a century (Zlotnik and Katiyar, 1961). From the outset, observations in the field posed the question of the relative parts played by inheritance (breed) and infection, and this remains a focal point of interest to the present day. Modern interest in scrapie has been intensified since 1954, when Sigurdsson delivered three lectures in the University of London in which he drew attention to certain naturally occurring diseases of sheep in Iceland which could, however, be passaged experimentally. Among these was the Icelandic disease called 'rida' (meaning 'trembling' and 'maedi' meaning 'breathlessness'). Rida appears to be identical with scrapie. Sigurdsson tentatively suggested three
Attendance in Adult Day Care Centers of Cognitively Intact Older Persons

The article aims to (a) examine the reasons for nonuse of ADCC, and (b) explore the reasons for use of adult day care centers (ADCCs) among users. The sample includes 819 respondents of whom 417 are users of 13 day care centers and 402 are nonusers, matched by age, gender, and family physician in the southern region of Israel. Data collection includes interviews that used a structured questionnaire. The most frequent reasons for nonuse of ADCCs are accessibility barriers, characteristics of participants and of the ADCCs, “no need for this service,” and personal difficulties. Those who use this service report that it improved their well-being, met their needs, enabled them to establish social relationships, and alleviated their family caregivers’ burden. ADCCs should be more responsive to the needs of various constituencies of frail older adults and be more accessible to those who do not use this type of service.
Anti-quorum sensing activity of phenolic extract from Eugenia brasiliensis (Brazilian cherry)

The aim of this study was to assess the anti-quorum sensing activity of phenolic extracts from grumixama (Eugenia brasiliensis), also known as Brazilian cherry, in concentrations that did not interfere with bacterial growth. The pulp phenolic compounds were extracted by using solid phage extraction in a mini-collumn C18 and quantified by spectrophotometry. The anti-quorum sensing activity was evaluated by testing the inhibition of violacein production in Chromobacterium violaceum and by evaluating the swarming motility in Aeromonas hydrophila and Serratia marcescens, both phenotypes regulated by quorum sensing. The phenolic extract strongly inhibited the production of violacein in C. violaceum, reducing its production in comparison with a control with no extract. No inhibition of growth was observed at the concentrations tested for quorum sensing inhibition. Confirming the quorum sensing inhibition phenotype, the extract was also able to inhibit swarming motility in S. marcescens and in A. hydrophila, although in the later the effect was marginal. Overall, these results indicate that phenolic extract from E. brasiliensis presents quorum sensing inhibitory activity most likely due to the presence of fruit phenolics which have been implicated as quorum sensing inhibitors in Gram negative bacteria.
Stress in assisted reproductive technology: Implications for nursing practice

In a follow-up study about women's experience of assisted reproductive technology (ART) some events were identified as particularly stressful, including making the decision to try ART, starting treatment, waiting for results after a scan, having oocyte collection, the 2 week wait after embryo transfer and finding out that the treatment was unsuccessful. On the basis of these findings, a review of the literature and extensive clinical practice as a nurse co-ordinator in an ART programme, implications for nursing practice are discussed and strategies to use that may help reduce stress and improve the well-being of ART participants are suggested.
The Digital User of Social Networks: A Comparative, Transcultural and Intergenerational Study

This article presents the results of a research study carried out in 2010 and 2011 on the evolution of the digital divide in two different cultural contexts: Europe and the United States of America. Using an Internet-based questionnaire parents and teenagers were surveyed regarding some variables related to their digital skills and their participation in social networks. Their answers were analyzed taking into account a range of factors such as age, gender and place of residence. The results highlight that there are significant differences between the United States of America and Europe regarding the presence of parents and teens on social networks, even though the generational digital divide decreases between minors and parents in both cultural contexts © 2013 IOJES. All rights reserved
Managing Depression During Pregnancy

Depression is a common illness during pregnancy, yet it often goes undetected and/or untreated. Untreated depression during pregnancy has been associated with increased rates of adverse maternal, obstetrical and fetal outcomes; consequently, it is crucial to manage these women effectively and adequately during this vulnerable time of their lives. The barriers to treatment include the stigma surrounding mental health and the challenges of navigating the constantly growing, and apparently conflicting, evidence regarding the safety of antidepressant use during pregnancy, as well as other concerns unique to pregnant women. In this paper, we suggest the management of women with depression during pregnancy, using evidence-based information, taking into account all of the aspects of treatment, including screening, risks of untreated depression and evaluation of the safety data regarding pharmaceutical treatments. In addition, we have designed a treatment algorithm to assist clinicians in making evidence-based decisions in this highly sensitive and complex clinical field. Finally, it is important to evaluate each woman on an individual, case-by-base basis, in order to ensure the best outcome for both the mother and her baby.
Anti-microbial antibodies in celiac disease: trick or treat?

AIM To determine the prevalence of a new set of anti-glycan and anti-outer membrane protein (anti-OMP) antibodies in a Hungarian cohort of adult Celiac disease (CD) patients. METHODS 190 consecutive CD patients [M/F: 71/119, age:39.9 (SD:14.1) years], 100 healthy, and 48 gastrointestinal controls were tested for glycan anti-Saccharomyces cerevisiae (gASCA), anti-laminaribioside (ALCA), anti-chitobioside, anti-mannobioside, anti-OMP antibodies and major NOD2/CARD15 mutations. Thirty out of 82 CD patients enrolled at the time of diagnosis were re-evaluated for the same antibodies after longstanding gluten-free diet (GFD). RESULTS 65.9% of the CD patients were positive for at least one of the tested antibodies at the time of the diagnosis. Except anti-OMP and ALCA, anti-microbial antibodies were exclusively seen in untreated CD; however, the overall sensitivity was low. Any glycan positivity (LR+: 3.13; 95% CI: 2.08-4.73) was associated with an increased likelihood ratio for diagnosing CD. Significant correlation was found between the levels of anti-glycan and anti-endomysial or anti-transglutaminase antibodies. Anti-glycan positivity was lost after longstanding GFD. Anti-glycan antibody titers were associated with symptoms at presentation, but not the presence of NOD2/CARD15 mutations. Patients with severe malabsorption more frequently had multiple antibodies at diagnosis (P = 0.019). CONCLUSION The presence of anti-glycan antibodies in CD seems to be secondary to the impaired small bowel mucosa which can lead to increased antigen presentation. Furthermore, anti-glycan positivity may be considered an additional marker of CD and dietary adherence.
Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels

New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (SNPs) in 1464 patients with T2D and 1467 matched controls, each characterized for measures of glucose metabolism, lipids, obesity, and blood pressure. With collaborators (FUSION and WTCCC/UKT2D), we identified and confirmed three loci associated with T2D—in a noncoding region near CDKN2A and CDKN2B, in an intron of IGF2BP2, and an intron of CDKAL1—and replicated associations near HHEX and in SLC30A8 found by a recent whole-genome association study. We identified and confirmed association of a SNP in an intron of glucokinase regulatory protein (GCKR) with serum triglycerides. The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases.