Miracle-dz/UniFAR-FTUs huggingface dataset:
Propofol-Thiopentone Admixture—Hypnotic Dose, Pain on Injection and Effect on Blood Pressure

This study examined some pharmacodynamic characteristics of two admixtures of propofol and thiopentone. Ninety unpremedicated ASA 1 or 2 patients were group-randomized to receive, in a double-blinded manner, one of the following mixtures for induction of anaesthesia: Group P50: propofol 1% 10ml/thiopentone 2.5% 10 ml; Group P75: propofol 1% 15 ml/thiopentone 2.5% 5 ml; Group P100: propofol 1% 20 ml/lignocaine 1% 4 ml. An additional 30 randomized but unblinded patients from the same patient cohort received thiopentone 2.5% to provide predictive dose data for groups P50 and P75. Haemodynamic data were collected pre- and post-induction. The required induction dose of both mixtures of propofol and thiopentone found an additive rather than a synergistic interaction with no significant difference between predicted and observed dose. Thiopentone resulted in significantly more rapid induction of anaesthesia than propofol/lignocaine or propofol/thiopentone. The addition of thiopentone to propofol was found to be as efficacious as the mixing of lignocaine with propofol in reducing pain on injection. The fall in systolic blood pressure was significantly less in group P50 compared with groups P75 or P100. Admixture of thiopentone with propofol results in an additive hypnotic effect, a reduction in pain of injection (comparable with addition of lignocaine) and a reduced hypotensive response compared to propofol injection alone during induction.
Prognostic Value of Lymph Node Ratio and Clinicopathologic Parameters in Patients Diagnosed With Stage IIIC Endometrial Cancer

OBJECTIVE: To estimate the prognostic significance of lymph node ratio with respect to clinicopathologic characteristics in stage IIIC endometrial cancer patients. METHODS: Using data from medical records and surgery notes, we identified all consecutive patients with stage IIIC endometrial cancer who received primary surgical treatment between 1993 and 2008. Lymph node ratio is the number of metastatic lymph nodes to the total number of removed lymph nodes. Survival analyses were performed using Kaplan–Meier and Cox proportional hazard methods. RESULTS: Two hundred sixteen patients with stage IIIC endometrial cancer were included in this multicenter study. Age, number of metastatic lymph nodes, lymph node ratio, grossly suspicious lymph nodes, histologic subtype, and cervical metastasis were associated with progression-free survival and overall survival, respectively. Patients with lymph node ratios 10% or less, more than 10–50%, and more than 50% had 5-year overall survival rates of 79.0%, 60.6%, and 35.8%, respectively (P<.001). In multivariable analysis, only lymph node ratio was associated with both progression-free survival and overall survival, respectively. Total number of removed lymph nodes and number of metastatic lymph nodes did not correlate with overall survival in the group with grossly suspicious lymph nodes, whereas lymph node ratio did. In the subgroup of 123 (56.9%) patients who had pelvic and aortic lymphadenectomies with a minimum of 10 lymph nodes removed, age and lymph node ratio were still associated with progression-free survival and overall survival, whereas total lymph nodes removed was not. CONCLUSION: Stratification based on lymph node ratio is useful when comprehensive lymphadenectomy is routinely performed and likely reflects metastatic nodal tumor burden. These data provide another prognostic variable in the heterogenic group of women with stage IIIC endometrial cancer. LEVEL OF EVIDENCE: II
Nicotine patch therapy prior to quitting smoking: a meta-analysis.

AIM To evaluate the incremental efficacy of starting nicotine patch treatment prior to quitting compared to the current regimen of starting patch treatment on the target quit day. DESIGN AND MEASUREMENTS Meta-analysis of four eligible studies using pre-cessation patch treatment, located by database search and contacts with cessation researchers. The studies all compared starting treatment with nicotine patch prior to the target quit date to starting active treatment at the quit date, some in the context of concurrent mecamylamine treatment. The primary end-point for the analysis was continuous abstinence for at least 28 days assessed at 6 weeks following quit day; 6-month outcomes were also examined. FINDINGS Compared to starting active patch treatment on quit day, pre-cessation treatment with nicotine patches was found to double the odds of quitting. This was true both at 6 weeks [pooled odds ratio (OR) = 1.96, 95% confidence interval (CI): 1.31-2.93] and 6 months (pooled OR = 2.17, 95% CI: 1.46-3.22) treatment outcomes. Mecamylamine co-treatment did not modify these effects. CONCLUSIONS Across the four studies analyzed, pre-cessation patch treatment was found to produce a robust increase in quit rates compared to current regimens starting patch at quit day. Pre-cessation patch use represents a promising innovation in smoking cessation therapy with potential beneficial implications for improved public health by further increasing quitting success.
Hospital stay of 2 days after open sigmoidectomy with a multimodal rehabilitation programme

Hospital stay after colonic surgery is usually between 5 and 10 days, limiting factors being pain, ileus, organ dysfunction and fatigue. Single‐modality intervention to reduce these factors with laparoscopic surgery usually requires a hospital stay of 5 days. This paper reports the results of a multimodal rehabilitation regimen after open sigmoidectomy.
Style and Personality in the Literary Work

Jn this paper I want to describe and defend a certain conception of literary style. If we look at literary style in the way I shall suggest, it will explain many of the problems that surround this elusive concept such as why something can be an element of style in the work of one author and not in another, what the difference is between individual style and general style, and how style differs from "signature. " The ordinary conception of style is that it consists of nothing but a set of verbal elements such as a certain kind of vocabulary, imagery, sentence structure and so on. On my conception, however, a literary style is rather a way of doing certain things, such as describing characters, commenting on the action and manipulating the plot. I shall claim that an author's way of doing these things is an expression of her personality, or, more accurately, of the personality she seems to have. The verbal elements of style gain their stylistic significance by contributing to the expression of this personality, and they cannot be identified as stylistic elements independently of the personality they help to express. Many theorists and critics have written as if style were an expression of personality. A good recent example is an essay on the first paragraph of Henry James' novel The Ambassadors, in.which the writer, Ian Watt, claims that
Web-Based Couple Interventions: Do They Have a Future?

To examine the current and potential future impact of formal and informal resources to enhance romantic relationships, 1,160 individuals were surveyed. When asked about resources previously used, participants reported that numerous forms of relationship help, including talking to a friend/coworker/family member, an individual therapist, and reading self-help materials had a larger impact than attending couple therapy. When asked about potential resources they would be likely to use in the future for relationship problems, participants indicated a strong preference for online self-help resources that included detailed feedback paired with a comprehensive, structured program. Implications for future development and dissemination are discussed.
Circulating miR-29 a , Among Other Up-Regulated MicroRNAs , Is the Only Biomarker for Both Hypertrophy and Fibrosis in Patients With Hypertrophic Cardiomyopathy

nstitute of Genetics and B ca Research Hospital, Mil derico II University, Na d Biotechnology, La S t of Cardiology, CARIM Maastricht, the Netherla Translational Sciences, ilano, Milan, Italy; and he purpose of this paper was to determine whether microRNAs (miRNAs) involved in myocardial remodeling were differentially expressed in the blood of hypertrophic cardiomyopathy (HCM) patients, and whether circulating miRNAs correlated with the degree of left ventricular hypertrophy and fibrosis.
Understanding Therapeutic Action in the Analytic Situation: A Second Look at The Developmental Metaphor

A root metaphor for the psychoanalytic therapeutic process is the mother-infant caretaking relationship. This developmental metaphor has assumed a dominant role for some analysts in how the psychoanalytic process and therapeutic relationship are conceptualized. In this paper, a distinction is made between two uses of the developmental metaphor–naïve and informed. The naïve view as commonly applied constrains our view of the unique relationship between analyst and analysand. The informed view takes into account current research in early social development that has emerged in the last decade of empirical studies with infants, young children, and their parents. While the parent-child relationship may be an inexact model for the analytic connection, some of the implications of the former, as they become more clearly understood in the course of careful research, may provide useful information about how change does or does not occur as a result of the analytic process, and how an analytic process needs to be in place in the analysand before that change can occur.
Watching the Watchdogs

Public life is a struggle for power, profile and privilege, yet like Diogenes we seek the honest man who will end all corruption. Today we are given government-begotten institutions vested with 'standing royal commission' powers. That they can't keep the executive, even the police, in check, and that power is toxic to some working in them, should by now be evident.
Coronary arteriography in the selection of patients for surgery.

The management of patients with coronary artery disease has proved to be one of the most difficult problems in clinical medicine. In the recent past, increasing interest has been shown in the surgical treatment of this condition, and the direct removal of obstructing lesions from the coronary arteries by thromboendarterectomy has been successfully performed (1, 5, 13). The selection of patients for this procedure is facilitated by the accurate preoperative localization of the site of obstruction. Coronary arteriography provides the surgeon with this much needed information. Rousthoi was probably the first investigator to demonstrate the coronary arteries in the intact experimental animal (12). Since then, many methods have been devised for their visualization. Intravenous angiocardiography reveals the coronary arteries only rarely. Furthermore, the detail with this technic is usually unsatisfactory, as a result of the residual filling of the underlying ventricular system with opaque material. The first su.
ssessing the cross-scale impact of 50 years of agricultural transformation in rgentina rnesto

Given the increasing number of actors related to farming that make decisions at different scales (plot, farm, region, etc.), knowledge about patterns and processes that behave hierarchically is increasingly needed. This is necessary in countries like Argentina, where cultivation expanded at increasing pace during the last 50 years over an area of 1.47 million km2. Relying on different sources of existing data, the purpose of this work was to assess the cross-scale dependence of patterns and processes related to the expansion of cultivation in Argentina. The study involved indicators of (i) carbon, nitrogen and phosphorous stocks, (ii) energy productivity, fossil energy consumption, C, N and P balances, water consumption and greenhouse gases fluxes, and (iii) impacts related to pesticide contamination, habitat intervention and soil erosion. Three scales involving (i) regions, (ii) macro-regions and (iii) the whole country were analyzed. Principal Components, Correlation and Regression Analysis were used to identify and quantify meaningful relationships between the different scales. The expansion of annual crops affected C–N–P stocks significantly at the regional scale, whereas it influenced energy and matter flows, and contamination across all scales. This finding explains conflictive responses to land use and management when different scales are considered and shows that scale dependency needs to be considered when their effects on the environment are explored and quantified.
Variation in the nature of attachment of phosphorylcholine to excretory–secretory products of adult Brugia pahangi

The mechanism of linkage of phosphorylcholine (PC) to excretory–secretory products (ES) of adult Brugia pahangi has been investigated. Biosynthetic radio-isotope labelling of ES with [3H]choline followed by SDS–PAGE/fluorography revealed a smear of molecular weight approximately 40–100 kDa which loses its radiolabel following exposure to N-glycosidase F, but not mild alkali. PC is thus attached to this smear of molecules via N-type glycans, a mechanism of linkage previously observed with respect to PC–ES of Acanthocheilonema viteae. Western blotting analysis of non-radiolabelled ES demonstrated the existence of additional PC–ES which were insensitive to N-glycosidase F, but not to alkali. This second group of molecules is therefore likely to contain PC linked to O-glycans. Filarial nematodes may thus utilize 2 classes of glycan for attachment of PC. Examination of B. pahangi and A. viteae whole worm extracts by Western blotting indicated that their PC content could not be cleaved by N-glycosidase F and hence the use of N-type glycans may be restricted to a subset of ES products. The implications of these findings with respect to developing inhibitors of PC attachment for use as anti-filarial drugs are discussed.
The immune response to the HPA‐la antigen: association with HLA‐DRw52a

Summary. Antibodies to the HPA‐la antigen can elicit a condition in the new‐born known as neonatal alloimmune thrombocytopenia (NAITP). Retrospective and prospective studies have shown that there is a strong correlation between the presence of HLA‐DR3, HLA‐DRw52 in the mother and the antibody response to HPA‐la. HLA Class II molecules play an important role in the initiation of the immune response and it has been postulated that HPA‐la antibody production could be determined by the presence of a specific HLA Class II molecule at the surface of the antigen‐presenting cell. Thirty‐one HPA‐la negative women with HPA‐la antibodies (responders) and nine HPA‐la negative women without HPA‐la antibodies (non‐responders) were recruited. They were studied using serological HLA Class I and Class II typing and RFLP analysis with a DRβ probe. We found that all responders had the HLA‐DRw52a sub‐specificity confirming recently published data. Moreover, two of the nine non‐responders were also found to be HLA‐DRw52a. These results suggest that the HLA‐DRw52a molecule is necessary for HPA‐la antibody responsiveness but not sufficient. The results also indicate that in HPA‐la negative women the absence of HLA‐DRw52a is associated with a very low risk of being antibody producers and hence, is associated with a very low risk for NAITP in their new‐borns.
The awareness of emotional intelligence by nurses and support workers in an acute hospital setting

This paper describes one component of the findings of a larger study exploring the experience of ward staff and their response to patient death in an acute hospital setting. A consistent theme arising from the study was the lack of awareness of the concept of emotional intelligence and the way this could be used to manage staff members own emotions in effectively handling stressful situations involving colleagues, patients and relatives. In this article the concept of emotional intelligence within nursing is examined, including how it is recognised and used by nurses and healthcare support workers. Differences between the two staff groups in the study, in relation to their awareness and use of emotional intelligence, are discussed along with consideration of how education can help staff to identify and develop their own level of emotional intelligence.
Effects of thyroid hormone on cardiac function: the relative importance of heart rate, loading conditions, and myocardial contractility in the regulation of cardiac performance in human hyperthyroidism.

The cardiovascular manifestations of thyroid hormone excess, including tachycardia, a widened pulse pressure, a brisk carotid and peripheral arterial pulsation, a hyperkinetic cardiac apex, and loud first heart sound have long been recognized and are a cornerstone for clinical diagnosis (1–9). A number of studies in the past decades have provided critical insights into the mechanisms that are responsible for the hyperdynamic cardiocirculatory state in overt hyperthyroid patients, suggesting that it probably results from the combined effects of thyroid hormone on certain molecular pathways on the heart and vasculature, at both the genomic and nongenomic level (10). Despite these advances, it is not yet clear whether, in spontaneous human hyperthyroidism, the high cardiac output state (11–24) is sustained prevalently by changes in peripheral hemodynamics (vascular hypothesis), or by changes in myocardial contractility (myocardial hypothesis) (19, 21). This issue has major clinical and pathophysiological implications. In fact, although peripheral and myocardial mechanisms are not mutually exclusive, the major contribution of one of the two mechanisms may have important consequences with regard to the “economy” of the cardiovascular system, given the notion that increased cardiac performance due to inotropic stimulation is less efficient than that due to modulation of the loading status. Accordingly, here we review research on the effects of spontaneous human hyperthyroidism on heart rate, preload, afterload, and myocardial contractility in an attempt to establish how these factors interact with each other and to what extent they contribute to increasing cardiac performance at rest.
The effect of genetically modified Lactobacillus plantarum 590 on the gut health of sprague–dawley rats

Lp was a generally recognized as safe microorganism. Lactobacillus plantarum 590 was obtained by inserting nisI gene into Lp genome to help it tolerate higher concentration nisin. As the unintended effects of the genetically modified microorganism (GMM) are the most important barriers to the progress of GMM, we have performed a useful exploration to establish a new in vivo evaluation model for GMM from the point of view of intestinal health. In this study, Sprague–Dawley rats were orally administered with Lp 590 and Lp for 4 weeks. Fecal samples were collected to determine the number of beneficial bacteria Bifidobacterium and harmful bacteria Clostridium perfringens. Denaturing gradient gel electrophoresis was used to detect the bacterial profiles of every group. Fecal enzyme activities and short‐chain fatty acids as main metabolites were also examined. Real time PCR (RT‐PCR) and immunohistochemistry were used to analyze two proteins (ZO‐1 and occludin) and secretory immunoglobulin A to detect intestinal permeability and mucosal immunity, gut permeability and gut mucosal immunity were analyzed to see whether GM Lp 590 can induce changes of the gut health when compared with non‐GM Lp group, andeventually we concluded that there is no significant difference between GM Lp 590‐fed group and non‐GM Lp‐fed group. The conclusion of gut health test was comparable withthat from traditional subchronic test. Evaluation of intestinal health will be a new approach of assessing the safety of GMM. © 2012 IUBMB Life, 64(7): 617–627, 2012.
DLEU2 encodes an antisense RNA for the putative bicistronic RFP2/LEU5 gene in humans and mouse

Our group previously identified two novel genes, RFP2/LEU5 and DLEU2, within a 13q14.3 genomic region of loss seen in various malignancies. However, no specific inactivating mutations were found in these or other genes in the vicinity of the deletion, suggesting that a nonclassical tumor‐suppressor mechanism may be involved. Here, we present data showing that the DLEU2 gene encodes a putative noncoding antisense RNA, with one exon directly overlapping the first exon of the RFP2/LEU5 gene in the opposite orientation. In addition, the RFP2/LEU5 transcript can be alternatively spliced to produce either several monocistronic transcripts or a putative bicistronic transcript encoding two separate open‐reading frames, adding to the complexity of the locus. The finding that these gene structures are conserved in the mouse, including the putative bicistronic RFP2/LEU5 transcript as well as the antisense relationship with DLEU2, further underlines the significance of this unusual organization and suggests a biological function for DLEU2 in the regulation of RFP2/LEU5. © 2004 Wiley‐Liss, Inc.
The effect of bone marrow and thymus chimerism between non‐obese diabetic (NOD) and NOD‐E transgenic mice, on the expression and prevention of diabetes

The non‐obese diabetic (NOD) mouse is an established animal model of the autoimmune disease, insulin‐dependent diabetes mellitus (IDDM). The NOD‐E mouse is a transgenic mouse which expresses the I‐E molecule (absent in NOD mice). Expression of I‐E protects these mice from both insulitis and IDDM.We have investigated the possible mechanisms of this protection by constructing bone marrow, and combined bone marrow and thymus chimeras between NOD and NOD‐E mice.
Reflection-Reduced Two-Layer Grating With Nearly 100% Diffraction Efficiency

A novel reflection-reduced two-layer grating is described with nearly 100% diffraction efficiency. The efficiency of the conventional grating should be improved, or some reported high-efficiency grating can work only for one polarization. The reflection-reduced grating can achieve high efficiency with a covering layer on the surface-relief grating. In addition, the two-layer grating can have wideband property compared with the single-layer grating. The presented novel grating can have merits of high efficiency of reflection-reduced grating and wideband property of two-layer grating. The modal method is applied to analyze the physical mechanism of high efficiency for both TE and TM polarizations. With the optimized grating parameters, efficiencies of 99.69% and 99.64% can be diffracted into the first order for the TE and TM polarizations, respectively. The moderate tolerance should make it possible to be fabricated easily for such a reflection-reduced two-layer grating, which can achieve nearly 100% diffraction efficiency for both the TE and TM polarizations.
Effect of Conjunctive Use of Phosphorus and Bio-Organics on Phosphorus Content and Uptake in Summer Groundnut (Arachis hypogaea L.)

The groundnut (Arachis hypogaea L.) is one of the important food legume crops of tropical and subtropical parts of the world. It is the world’s most popular oilseed crop cultivated in more than 100 countries in all the six continents. Groundnut kernel contains above 40% edible oil, around 25% protein and 18% carbohydrates along with minerals and vitamins. Groundnut oil is free from cholesterol and contains less than 20% saturated fatty acid and hence is heart friendly. Groundnut oil is also considered as the staple and nutritive, as it contains just the right proportion of oleic (46.5%) and linoleic (31.4%) acids (Mathur and Khan, 1997). Phosphorus play beneficial role in the root development, nodulation and stimulation of the symbiotic nitrogen fixation. It enhances root development and nodulation, improves the supply of nutrients and water increase in photosynthetic area resulting in more dry matter accumulation and yield (Rajanikanth et al., 2008). Phosphorous appear to be a limiting factor in yield. It promotes root development, flowering and fruiting and aids in setting of kernels. It is reported (Nair et al., International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 6 Number 8 (2017) pp. 1618-1621 Journal homepage: http://www.ijcmas. com