Miracle-dz/UniFAR-FTUs huggingface dataset:
Expression of Ly-6C by T Lymphocytes of NOD Mice After CD3-Complex Stimulation: Identification of Activated Cells During Insulitis of Prediabetic Mice

Ly-6C is a differentiation antigen that distinguishes T-lymphocyte subsets. In concordance with previous results, splenocytes from NOD mice do not express the epitope recognized by anti-Ly-6C monoclonal antibodies (MoAbs), including MoAb HK1.4 in this study, and cannot be stimulated to proliferate in response to HK1.4. However, when splenocytes from NOD mice were stimulated in vitro with the anti-CD3 MoAb 145–2C11, T lymphocytes expressing Ly-6C were detected after 48 h of stimulation, with as many as 25% of lymphocytes expressing this antigen with prolonged passage in culture. Most of the cells expressing Ly-6C were Thy-1.2+, CD4+, and CD8 and proliferated after stimulation with HK1.4. To further understand the failure of NOD splenocytes to express Ly-6C, freshly isolated cells were stimulated with α/β-interferon (IFN-α/β) and IFN-γ. Although these lymphokines induced expression of Ly-6A and Ly-6C in splenocytes from C57BL/6J mice and Ly-6A in NOD cells, Ly-6C was not induced on NOD cells. Because Ly-6C expression on splenocytes was a marker of activation via the CD3 T-lymphocyte receptor complex, we also examined expression of Ly-6C on T lymphocytes within islets showing insulitis in vivo. Lymphocytes that were Ly-6C+ were identified within islets on histological sections of pancreas, whereas Ly-6C+ cells in the spleen from the same mouse could not be detected. Our findings imply functional abnormality in expression of Ly-6C in NOD mice. These results suggest that Ly-6C+ cells that are present in islets showing insulitis of the NOD mouse have been stimulated through the CD3 complex or associated molecules, and this marker will provide the means to identify and isolate antigen-specific cells from that site.
Misclassification of Negative Core Earnings and Signal-Driven Price Association

This paper provides evidence that managers strategically report large negative special items (NSP hereafter) when the current year’s expected core earnings deviate from the previous year’s reported core earnings benchmark. The strategic reporting of NSP is consistent with misclassifying negative core earnings (operating expenses and losses) as NSP and is more likely associated with poor financial reporting firms. Decomposing NSP into misclassified negative core earnings and real NSP reveals that only the noneconomically-based component of NSP is associated with subsequent financial restatements. The misclassification practice is consistent with a conjecture by managers that misclassified negative core earnings receive less valuation implications. Consistent with this conjecture, I find that the misclassified component forecasts earnings similar to reported core earnings; however it receives an ERC (earnings response coefficient) that is inconsistent with its forecasting ability. Further results show that changes in stock price association with NSP are mainly driven by a “noisy” reporting signal of misclassification.
Temperature and Background Field Dependence of Thermal Stability in a Compact MgB 2 Solenoid Coil

A conduction-cooled compact react and wind MgB2 solenoid magnet was tested for quench propagation and minimum quench energy (MQE) in a background field, which allows to an extent a decoupling of the peak field in the windings from the conductor field performance. MQE and propagation data were taken in self-field at 30 K, 30.5 K, and 31.5 K and at fields/temperatures of 1 T/25 K, 3 T/18 K, and 5 T/10 K where the power law n-value characteristic was similar at n ~ 30. At all temperatures and at low I/Ic, quench propagated first through the insulating layers, in a radial direction, and at high I/Ic within the layer. The MQE values as a function of I/Ic are shown to consistently have nonzero values as I → Ic, which is characteristic of an analytical quench model that includes the n-value power law dissipation. At 30.5 K, a sharp drop in MQE occurs along with the change in propagation direction. The analytical model is then exploited as 1-D adiabatic, 3-D infinite solenoid, and 3-D with heat transfer at the boundary to explore the effect of dimensionality and conduction cooling on the propagation and MQE behavior.
Cross-cultural Validation of a Disease-specific Patient-reported Outcome Measure for Systemic Lupus Erythematosus in Canada

Objective. The LupusPRO, a disease-targeted patient-reported outcome measure, was developed and validated in US patients with systemic lupus erythematosus (SLE). We report the results of the cross-cultural validation study of the English version of the LupusPRO among patients in Canada with SLE. Method. The LupusPRO was administered to English-speaking Canadian patients with SLE. Demographic, clinical, and serological characteristics were obtained, and the Medical Outcomes Study Short Form-36 (SF-36) and LupusPRO were administered. Disease activity was ascertained using the Safety of Estrogens in Lupus Erythematosus National Assessment-Systemic Lupus Erythematosus Disease Activity Index (SELENA-SLEDAI) and the Lupus Foundation of America definition of flare (Yes/No). Damage was assessed using the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI). Physician disease activity and damage assessments were also ascertained using visual analog scales. A mail-back LupusPRO form was completed within 2–3 days of the index visit. Items tested were internal consistency reliability (ICR), test-retest reliability (TRT), convergent and discriminant validity (against corresponding domains of the SF-36), criterion validity (against disease activity or health status), and known-groups validity. Results. Participants were 123 Canadian patients with SLE (94% women); mean age was 47.7 (SD 14.8) years. The median (interquartile range) SELENA-SLEDAI and SDI were 4 (6) and 1 (3), respectively. The ICR of the LupusPRO domains ranged from 0.60 to 0.93, while the TRT range was 0.62–0.95. Measures observed were convergent and discriminant validity with corresponding domains of SF-36, criterion validity, and known-groups validity against disease activity, damage, and health status. Confirmatory factor analysis showed a good fit. Conclusion. The LupusPRO has fair psychometric properties among Canadian patients with SLE, and prospective studies to establish minimally important difference are continuing.
Turnover intention (Job characteristics perspective) among electrical and electronics sub-sector employees in Malaysia

Job turnover is traditionally faced by organizations in many industries.Implications such as resources wastage and low productivity can be derived from turnover issue.Turnover intention was found to be a reliable predictor for actual turnover in previous studies.Consequently, this demands some insights on turnover intention issue especially within Malaysian context.This paper will focus on determining the relationship of job characteristics on turnover intention among manufacturing operators particularly in Electrical and Electronics sub-sector.The study was conducted amongst the operators of manufacturing industry in Peninsular Malaysia (N=800). Considering that Malaysia manufacturing industry has shown a strong economic growth through large investment in economic activities, it is important for all manufacturing companies to retain talented employees and reduce turnover problem in order to be more productive and competitive. The findings had accepted the research hypothesis. Dimensions of job characteristics (i.e. skill variety, task identity and feedback) had significantly correlated and contributed to the turnover intention.The findings had contributed to the theoretical significance through the examination of direct relationships between job characteristics on turnover intention among local operators in manufacturing sector based on the high turnover rate in Malaysia manufacturing sector between the years 2008 until early of 2011.
Work life and mental well-being: single and coupled employed mothers in Southern Europe and Scandinavia

Many European mothers, single and coupled, combine work outside the home and family life. The effects of this on their mental well-being may vary depending on the level of support available from the State’s welfare system, since welfare may buffer working mothers from some of the stress that can arise from trying to manage significant responsibilities on the job and at home. Welfare may be especially important for single working mothers, for whom the burden of multiple roles may be even heavier. The present study assessed levels and predictors of well-being of single and coupled employed mothers in Greece, Portugal and Spain, where welfare support is relatively limited. Results were compared to a parallel study with data from Denmark, Norway and Sweden, where welfare support is relatively comprehensive. Coupled mothers in Scandinavia had significantly lower financial hardship, longer education, higher life satisfaction, more enriching jobs, practical support, financial support and social participation than coupled mothers in the Southern European sample. On the other hand, the Scandinavian coupled mothers had higher levels of work family conflict than coupled mothers in Southern Europe. Single mothers in Scandinavia, compared to single mothers in Southern Europe, had significantly longer education, higher life satisfaction and positive affect, more enriching jobs, confidant support, practical support, financial support and social participation. Level of job stress was the same for all mother groups. All groups differed significantly from each other in level of financial hardship, with Scandinavian coupled mothers being best off, followed by Scandinavian single mothers, Southern European coupled mothers, and Southern European single mothers. The regional differences suggest that single motherhood per se need not be a risk factor for poorer well-being, and that welfare policies may have a protective effect for the mental well-being of single mothers. (Global Health Promotion, 2009; 16(3): pp. 06—16)
Coherence Shifts in Probabilistic Inference Tasks

The fast-and-frugal heuristics approach to probabilistic inference assumes that individuals often employ simple heuristics to integrate cue information that commonly function in a non-reciprocal fashion. Specifically, the subjective validity of a certain cue remains stable during the application of a heuristic and is not changed by the presence or absence of another cue. The parallel-constraint-satisfaction model, in contrast, predicts that information is processed in a reciprocal fashion. Specifically, it assumes that subjective cue validities interactively af-fect each other and are modified to coherently support the favored choice. Corresponding to the model’s simulation, we predicted the direction of such coherence shifts.Cue validities were measured before, after (Exp. 1) and during judgment (Exp. 2 & 3). Coherence shifts were found in environments involving real-world cue knowledge (weather forecasts) and in a domain for which the application of fast-and-frugal heuristics has been demonstrated (city-size tasks). The results indicate that subjective cue validities are not fixed parameters, but that they are interactively changed to form coherent representations of the task.
Socioeconomic Status and Obesity among Semi-Urban Nigerians

Objective: The relation between socioeconomic status (SES) and obesity in Sub-Saharan Africa (SSA) has been inconsistent. Methods: This study examined the prevalence of obesity and SES/obesity relations in 1,067 adults aged 30–60 years from a semi-urban Nigerian population. A structured questionnaire validated by a pictorial selfrating ladder was used to determine the participants’ SES. Results: SES was found to be inversely related (p < 0.010) to weight and BMI, respectively. The odds ratio (OR) and 95% confidence interval (CI) for obesity among lower SES individuals were OR 2.4 and CI 1.91–2.88 compared with OR 2.9 and CI 2.42–3.39 in those of the middle and higher socioeconomic strata. Among males, the OR and 95% CI for obesity among lower SES individuals were OR 1.9 and CI 1.21–2.59 compared with OR 1.7 and CI 1.00–2.39 in those of the middle and higher socioeconomic strata. Among females, the OR and 95% CI for obesity among lower SES individuals were OR 3.0 and CI 2.32–3.68 compared with OR 4.7 and CI 4.02–5.38 in those of the middle and higher socioeconomic strata. Conclusion: SES was inversely associated with the risk of obesity, with a higher prevalence of obesity in the lower socioeconomic stratum of the semi-urban Nigerian population.
The sources of legitimacy for new venture angel investors

We examine the relation between legitimacy and angel investor assessment. Employing two common measures of legitimacy including sociopolitical normative, and cognitive as well as a third based on the industry of operation we find that sociopolitical and cognitive sources are predictive of angel investor interest. Specifically entrepreneurial ventures with quality top management teams, identified external investors and advisors, along with developed products are rated more favorably by angel investors, have better access to these investors, and are more likely to receive investments. This research provides new insights into the establishment of legitimacy within the economically important angel capital market.
Determinants of oral health‐related quality of life of the institutionalized elderly

Diminished oral health of the institutionalized elderly has frequently been reported. This is not only of significance with regard to nutrition and general health, but it can also affect oral health‐related quality of life. This paper evaluates the effects of oral and general conditions on oral health‐related quality of life for the institutionalized elderly, as measured by the Geriatric Oral Health Assessment Index (GOHAI).
Explaining Children’s Wh-in situ Questions: Against Economy

Human language permits both fronted and in situ constructions of whquestions. Many languages permit only one of these options in main clause information-seeking questions. These are questions that can be uttered “out of the blue,” without any particular preceding discourse context. For example, English requires fronting in such questions, or overt movement of the whphrase, as in (1), while Mandarin disallows it, as in (2).
Co-Culture of Human Adipose-Derived Stem Cells with Tenocytes Increases Proliferation and Induces Differentiation into a Tenogenic Lineage

Background: Seeding acellularized tendons with cells is an approach for creating tissue-engineered tendon grafts with favorable biomechanical properties. It was the authors’ aim to evaluate whether human adipose-derived stem cells could replace tenocytes for scaffold seeding. Methods: Adipose-derived stem cells and tenocytes were co-cultured in different ratios (3:1, 1:1, and 1:3) and with three different methods: (1) direct co-culture, (2) tenocyte-conditioned media on adipose-derived stem cells, and (3) an insert system to keep both cell types in the same media without contact. Proliferation, collagen production, and tenogenic marker expression were measured by hematocytometry, immunocytochemistry, enzyme-linked immunosorbent assay, and real-time polymerase chain reaction. Results: Proliferation and collagen production were similar for tenocytes and adipose-derived stem cells alone. Phenotype difference between adipose-derived stem cells and tenocytes was indicated by higher tenascin C and scleraxis expression in tenocytes. Proliferation was increased in direct co-cultures, especially at an adipose-derived stem cells–to-tenocyte ratio of 3:1, and for tenocytes in adipose-derived stem cell–conditioned media. Direct co-culture caused significant up-regulation in tenascin C expression in adipose-derived stem cells (4.0-fold; p < 005). In tenocyte-conditioned media, tenascin C expression was up-regulated 2.5-fold (p < 0.05). In the insert system, tenascin C expression was up-regulated 2.3-fold (p < 0.05). Conclusions: Adipose-derived stem cells are good candidates for tendon tissue engineering because they are similar to tenocytes in proliferation and collagen production. With an optimal ratio of 3:1, they increase proliferation in co-culture and change their phenotype toward a tenogenic direction.
FASTING AND REFEEDING: CELL KINETIC RESPONSE OF JEJUNUM, ILEUM AND COLON

Following a period of fasting, feeding a normal diet results in a burst of DNA synthesis in the crypts of the colonic epithelium. This is due largely to a prompt entry of cells, blocked in G1, into S. Peak levels of S cellularity exceed 4 times the fasting, and 2 times the normal fed, control values. Refeeding a low residue diet (soluble casein, glucose and corn oil) results in a return to control levels of proliferative activity, but no hyperplasia.
Prophylactic Intravesical Instillation of Epinephrine Prevents Cyclophosphamide-Induced Hemorrhagic Cystitis in Rats

The objective of this study is to investigate the potential protective effects of intravesical instillation of epinephrine in cyclophosphamide-induced hemorrhagic cystitis. In an earlier study, we have shown that epinephrine promotes hemostasis on established hemorrhagic cystitis induced by cyclophosphamide. Female Sprague-Dawley rats were divided into seven groups as follows: group 1: positive control (150 mg/kg, cyclophosphamide, i.p.), group 2: negative control (10 μ g/ml, epinephrine, intravesical), co-administration of cyclophosphamide (150 mg/kg, i.p.), group 3: saline (intravesical), groups 4–6: epinephrine (2.5, 5, and 10 μ g/ml, intravesical), and group 7: mesna (50 mg/kg, i.p.). Rats were sacrificed on 3 consecutive days and the urinary bladders were removed, weighed, and evaluated. The vesical vascular permeability was determined by wet bladder weight and Evan’s blue dye absorbance. After 24 hours of cyclophosphamide administration, severe hemorrhagic cystitis was induced with marked edema, hemorrhage, and inflammation. In the epinephrine-treated groups, symptoms of hemorrhagic cystitis (such as edema, inflammation, and hemorrhage) were reduced significantly. Intravesical instillation of epinephrine prevents edema, hemorrhage, and inflammation in rats with cyclophosphamide-induced hemorrhagic cystitis.
Different facets of tree sapling diversity influence browsing intensity by deer dependent on spatial scale

Abstract Browsing of tree saplings by deer hampers forest regeneration in mixed forests across Europe and North America. It is well known that tree species are differentially affected by deer browsing, but little is known about how different facets of diversity, such as species richness, identity, and composition, affect browsing intensity at different spatial scales. Using forest inventory data from the Hainich National Park, a mixed deciduous forest in central Germany, we applied a hierarchical approach to model the browsing probability of patches (regional scale) as well as the species‐specific proportion of saplings browsed within patches (patch scale). We found that, at the regional scale, the probability that a patch was browsed increased with certain species composition, namely with low abundance of European beech (Fagus sylvatica L.) and high abundance of European ash (Fraxinus excelsior L.), whereas at the patch scale, the proportion of saplings browsed per species was mainly determined by the species’ identity, providing a “preference ranking” of the 11 tree species under study. Interestingly, at the regional scale, species‐rich patches were more likely to be browsed; however, at the patch scale, species‐rich patches showed a lower proportion of saplings per species browsed. Presumably, diverse patches attract deer, but satisfy nutritional needs faster, such that fewer saplings need to be browsed. Some forest stand parameters, such as more open canopies, increased the browsing intensity at either scale. By showing the effects that various facets of diversity, as well as environmental parameters, exerted on browsing intensity at the regional as well as patch scale, our study advances the understanding of mammalian herbivore–plant interactions across scales. Our results also indicate which regeneration patches and species are (least) prone to browsing and show the importance of different facets of diversity for the prediction and management of browsing intensity and regeneration dynamics.
Pengaruh Mekanisme Good Corporate Governance (GCG) terhadap Nilai Perusahaan pada Perusahaan yang Listing di Bei

The purpose of this study was to determine the effect of managerial ownership, institutional ownership and independent directors to corporate value. The population in this study amounted to 383 companies. Sampling in this study using purposive sampling and obtained 66 samples. This study tested using regression analysis techniques. The results of this study indicate that (1) Managerial ownership negative effect on the value of the company. (2) Institutional ownership has no effect on the value of the company. (3) Independent commissioner has positive effect on firm value
The staining pattern of collagen fibrils. I. An analysis of electron micrographs.

Electron micrographs of calf-skin collagen in the reconstituted native-type fibril and the segmented long spacing (SLS) forms are matched with one another and with the distribution of charged residues in the known α1 chain sequence.It is shown that:a) the pattern of bands in SLS corresponds closely with the charge distribution in the sequenceb) most of the bands in the fibril pattern can be matched in position (but not in intensity) to bands in the SLS pattern, confirming a substantial measure of matching of charged regions with charged regions (and therefore of hydrophobic regions with hydrophobic regions) on assembly of molecules into fibrilsc) when the al chain sequences are regularly staggered by 233 residues (to simulate the postulated packing in a fibril) the greatest concentrations of charged residues occur in regions which correspond closely with the bands in positively stained fibrilsd) the positions of the abrupt contrast steps(the overlaplgap junctions) in the image of a negatively contrasted f.
Efficient use of continuous, real-time prostate localization

Recent technological advances make it possible to monitor prostate movement during radiation delivery. Using previously published data from 35 patients who underwent continuous localization during prostate cancer treatment, we simulated various interventions to identify the radiation-gating and patient-repositioning strategies that least prolonged the time to complete the daily treatment. Acceptable response protocols were those that resulted in at least 95% of patients' prostates remaining within the planning margins at least 95% of the time. Gating and repositioning were not necessary for margins of 7 or 10 mm because of the rarity of excursions at these margins. However, intervention was routinely necessary for margins of 3 and 5 mm. In simulated interventions for which the therapist could reposition the treatment couch without entering the room, the most time-efficient response protocol was to reposition the couch immediately after the prostate position was outside the treatment margins. In simulations in which the therapist had to enter the room to reposition the couch, overall treatment time could be reduced and accuracy could be increased by manually gating treatment for 11 and 21 s for 3- and 5-mm margins, respectively, before interrupting treatment to reposition the treatment couch.