Miracle-dz/UniFAR-FTUs huggingface dataset:
Cloning, complementation, and characterization of an rfaE homolog from Neisseria gonorrhoeae

Neisseria gonorrhoeae WS1 is a spontaneous pyocin (a bacteriocin produced by Pseudomonas aeruginosa)-resistant mutant of N. gonorrhoeae FA19 that produces a truncated lipooligosaccharide (LOS) and is non-transformable. The LOS-specific mutation in WS1 was moved into a transformable background by transforming FA19 with chromosomal DNA from WS1 (generating strain JWS-1). A clone (pJCL2) capable of restoring JWS-1 to wild-type LOS expression, as detected by its acquisition of reactivity with monoclonal antibodies and by its complemented sodium dodecyl sulfate-polyacrylamide gel electrophoresis profile, was isolated. Sequential unidirectional deletion and DNA sequence analysis of pJCL2 identified an open reading frame, designated lsi-7, that could complement the defect in JWS-1. Homology searches against various databases indicated that lsi-7 bad homology with several Escherichia coli genes involved in the phosphorylation of sugars. lsi-7 is adjacent to the lsi-6 gene, another gene involved in LOS biosynthesis. Complementation studies using Salmonella typhimurium lipopolysaccharide mutants showed lsi-6 and lsi-7 to be gonococcal homologs of S. typhimurium rfaD and rfaE, respectively. Reverse transcriptase PCR analysis demonstrated that lsi-6 and lsi-7 are part of the same transcriptional unit.
Professing Educational Leadership: Conceptions of Power

This article focuses on power, its conception, and its enactment during decision making. Its purpose is to lay the groundwork for the intentional infusion into educational leadership preparation programs of classroom experiences that develop, encourage, and support leaders who attend to social justice issues while making decisions related to children. The article begins with a discussion of two modern conceptions of power and a mixed version of the two, followed by an exploration of the relationship between conceptions of power and the enactment of power in decision making. The second part of the article is in the form of a case that has been designed to draw attention to some of the difficulties administrators encounter when they try to understand and use power with others rather than over others. The case study is based on actual events that have occurred in public school settings. The final part of the article contains a self-reflective experience designed to facilitate the exploration of an individual's conceptualization of the term power.
Botulinum Toxin a for Chronic Daily Headache: A Randomized, Placebo-Controlled, Parallel Design Study

Sixty patients with headaches of more than 15 days per month were recruited for this double-blind, placebo-controlled, parallel study of botulinum toxin type A (BTX) for chronic tension type and chronic migraine headaches. The primary efficacy point was the number of headache-free days as assessed by diary for 12 weeks after BTX injection. Secondary efficacy points included global impressions, the use of abortive headache medications, and palpation. After recruitment, subjects kept diaries for 4 weeks prior to randomization, at which time they received either 200 U of BTX or matching placebo and were followed. After the week-12 evaluation, patients were offered 200 U of BTX (open label), and were similarly followed for another 12 weeks. The mean days with headache of the 60 subjects (49 female, mean age 47 ± 11 years) was 23 ± 7 out of 30. Both groups were demographically similar (58 completed). Over a 12-week period after injections, headache-free days had improved in the BTX group from week 8 to 12 (P < 0.05), and strongly tended to improve over the entire 12-week period, 33 ± 23 vs. 24 ± 16 days without headache (P = 0.07), but did not meet the a priori significance criteria. The subject global impressions (P < 0.05), subject change in headache impressions (P < 0.005), and investigator global impressions (P < 0.001) all improved in the BTX group compared with placebo. Adverse events were mild and did not differ between groups. At week 24 (open label), headache-free days were less in the twice BTX injected group compared with the once injected group, 40 ± 26 vs. 26 ± 19 (P < 0.05). BTX may help chronic daily headache and appears to have a cumulative effect with subsequent injections. The treatment was very well tolerated.
Co-existence of cerebral cysticercosis with Japanese encephalitis: a prognostic modulator

In this study, we investigated the frequency of co-existence of cerebral cysticercosis (CC) in Japanese encephalitis (JE) cases with special emphasis on its role in predicting the final clinical outcome. Amongst the 163 confirmed cases of JE, 37·42% (61/163) had co-existent CC. This was confirmed by antibody detection in the CSF of 45 cases, CT scan of the brain in 6 cases and at autopsy in 3 cases. In 2 cases confirmation was possible by CT scan as well as at autopsy, in 4, CSF antibody levels and CT scan were suggestive of CC while in 1, CSF antibodies and autopsy were suggestive of CC. The co-occurrence of Cysticercus cellulosae in the brain emerged as a prognosticator of poor outcome in JE cases (P<0·03).
Predicting protean and physical boundaryless career attitudes by work importance and work alternatives: regulatory focus mediation effects

Abstract Prediction of protean and physical boundaryless career attitudes (organizational mobility preference) was investigated through two work cognitions: work importance and work alternatives. Regulatory focus theory served to explore mediation effects in these predictive relations. Respondents were 336 engineers and computer scientists employed in Israel’s hi-tech industry in a post-organizational downsizing period. Results of the direct model showed that perceptions of work importance were related to protean career attitude and not to physical boundaryless career attitude, while perceived work alternatives were related to both career attitudes, but more to the physical boundaryless. The mediated model showed that the promotion motive predicted increase and the prevention motive predicted decrease in both career attitudes, implying that both were triggered more by motives for opportunities and gains than by fears. These results contribute to knowledge on career self-management in the context of repeated organizational downsizings, and underscore the importance of designing human resource career policies that consider employees’ work values and work alternatives.
Neighborhood Affluence, School-Achievement Scores, and Housing Prices: Cross-Classified Hierarchies and HLM

The housing literature has traditionally employed hedonic price models to investigate the impact of house and neighborhood characteristics on housing prices. These models, however, are not necessarily equipped to take into account the cross-classified, hierarchical nature of housing markets. This paper employs a hierarchical linear model (HLM) to examine the impact that housing characteristics, neighborhood affluence, and school-achievement scores have on housing prices in a cross-classified setting within a single municipality. More specifically, this paper analyzes the impact that differences in affluence across neighborhoods and school-achievement scores across school zones have on the valuation of certain individual housing characteristics in particular and, through them, on housing prices in general.
Modelling and Assessment of Inert Gas Behaviour in UO2 Nuclear Fuel for Transient Analysis

In this chapter, I present a model describing the evolution of intra-granular inert gas bubbles in terms of bubble number density and average bubble size. The model considers the fundamental processes of single gas atom diffusion, gas bubble nucleation, bubble re-solution, and gas atom trapping at bubbles. I derived the model from a detailed cluster dynamics formulation, under the experimentally corroborated assumption that free vacancies are of secondary importance compared to gas atoms in particular conditions. By rigorous simplification, I reduced the master equations of cluster dynamics to three differential equations, being efficiently applicable in engineering fuel performance codes while retaining a physical basis. After implementation in the SCIANTIX code, I validated the model against separate effect experimental data, both in terms of bubble number density and average bubble radius finding an improved agreement compared to other models currently available in fuel performance codes. I performed an uncertainty analysis by propagating the uncertainties in the parameters to the model results, and a sensitivity analysis showing the importance of each model parameter as well. The content of this Chapter is based on: D. Pizzocri, G. Pastore, T. Barani, A. Magni, L. Luzzi, P. Van Uffelen, S.A. Pitts, A. Alfonsi, J.D. Hales, 2018, A model describing intra-granular fission gas behaviour in oxide fuel for advanced engineering tools. Journal of Nuclear Materials, 502, 323-330.
Atlantic salmon return rate increases with smolt length

Recent declines in Atlantic salmon Salmo salar populations are generally attributed to factors in their marine life-phase. However, it is postulated that factors affecting their freshwater life-phase might impact their marine survival, such as the influence of body size. While larger smolts are widely hypothesized to have higher marine survival rates, empirical support remains scant, in part due to inadequate data and ambiguous statistical analyses. Here, we test the influence of smolt body size on marine return rates, a proxy for marine survival, using a 12-year dataset of 3688 smolts tagged with passive integrated transponders in the River Frome, Southern England. State-space models describe the probability of smolts surviving their marine phase to return as 1 sea-winter (1SW) or multi-sea-winter adults as a function of their length, while accounting for imperfect detection and missing data. Models predicted that larger smolts had higher return rates; the most parsimonious model included the effect of length on 1SW return rate. This prediction is concerning, as freshwater juvenile salmon are decreasing in size on the River Frome, and elsewhere. Thus, to maximize adult returns, restoration efforts should focus on freshwater life-stages, and maximize both the number and the size of emigrating smolts.
Timing effects and the interpretation of period fertility

Low fertility levels and later childbearing in many developed countries have reinvigorated the debate between period and cohort perspectives on fertility and on the meaningfulness of the period total fertility rate (TFR). Here, fertility-timing effects are defined as level changes in period fertility that do not reflect level changes in the completed fertility of cohorts. That definition leads to the average cohort fertility (ACF) as a measure of period fertility adjusted for timing effects. In an influential paper, Bongaarts and Feeney (1998) presented an alternative approach and a different measure, TFR*, to adjust for timing effects. Here, the two measures are compared. In the context of model populations, the ACF performs well, reflecting an average of the fertility of the active cohorts. The Bongaarts-Feeney TFR*, however, is frequently unreliable and can be erratic when there are cycles in period timing. When applied to twentieth-century U.S. experience, the TFR* behaves like a period measure and yields adjustments that are often wide of the mark. The ACF shows the stability associated with cohort measures and quantifies the substantial impact that timing effects had during the “birth dearth” of the 1970s. The period TFR reached a low of 1.74 in 1976, but the ACF never went below 2.06 during the 1970s.
Is the Intergenerational Income Elasticity a Sufficient Statistic for Fairness?

Recent estimates of intergenerational income transmission suggest that there are vast cross-country differences in economic mobility. Under the most common models this is attributed to a combination of credit constraints and failure of some nations to adequately invest in the human capital of poor children. These models sometimes lead to the presumption that intergenerational mobility measures capture indices of fairness or opportunity and to policy recommendations to lower them. In this paper we show that such reasoning is premature. We present an alternative model, which makes many of the same observed predictions as educational underinvestment models, but has the opposite normative conclusions. In this model the disincentive effects of labor market taxation and redistribution, not public educational underinvestment, drive cross-country differences in intergenerational mobility. We test the predictions of our model using data on income mobility, tax rates, and public expenditures. The data largely supports the model predictions.
Exact Recovery of Hard Thresholding Pursuit

The Hard Thresholding Pursuit (HTP) is a class of truncated gradient descent methods for finding sparse solutions of $\ell_0$-constrained loss minimization problems. The HTP-style methods have been shown to have strong approximation guarantee and impressive numerical performance in high dimensional statistical learning applications. However, the current theoretical treatment of these methods has traditionally been restricted to the analysis of parameter estimation consistency. It remains an open problem to analyze the support recovery performance (a.k.a., sparsistency) of this type of methods for recovering the global minimizer of the original NP-hard problem. In this paper, we bridge this gap by showing, for the first time, that exact recovery of the global sparse minimizer is possible for HTP-style methods under restricted strong condition number bounding conditions. We further show that HTP-style methods are able to recover the support of certain relaxed sparse solutions without assuming bounded restricted strong condition number. Numerical results on simulated data confirms our theoretical predictions.
Cytologic separation of branchial cleft cyst from metastatic cystic squamous cell carcinoma: A multivariate analysis of nineteen cytomorphologic features

The separation of branchial cleft cysts from metastatic cystic squamous cell carcinomas in adults can be clinically and cytologically challenging. Diagnostic accuracy for separation is reported to be as low as 75% prompting some authors to recommend frozen section evaluation of suspected branchial cleft cysts before resection. We evaluated 19 cytologic features to determine which were useful in this distinction.
Single-Battery-Powered CMOS/MEMS Respiration Detection Monolithic Chip

This work proposes a respiration detection monolithic chip, which integrates MEMS sensors, CMOS sensing circuits, an analog-to-digital converter, and three low dropout regulators into a single chip. Hence, this chip can be directly powered by a single Li-ion battery. The proposed chip was designed and fabricated using TSMC 0.35 μm CMOS/MEMS 2P4M mixed-signal polycide process. Moreover, to solve the issue of particle deposition, it tries to cover the proposed chip with a thin and soft layer of polydimethylsiloxane.
Diuretics

Diuretics have been recommended as first-line treatment of hypertension and are also valuable in the management of hypervolemia and electrolyte disorders. This review summarizes the key features of the most commonly used diuretics. We then provide an update of clinical trials for diuretics during the past 5 years. Compared to other classes of medications, thiazide diuretics are at least as effective in reducing cardiovascular events (CVEs) in patients with hypertension and are more effective than β-blockers and angiotensin-converting enzyme inhibitors in reducing stroke. Observational cohort data and a network analysis have shown that CVEs are lowered by one-fifth from chlorthalidone when compared to the commonly used thiazide, hydrochlorothiazide. Relative to placebo, chlorthalidone increases life expectancy. In those aged 80 years and older, the diuretic, indapamide, lowers CVEs relative to placebo. The aldosterone antagonist, eplerenone, lowers total mortality in early congestive heart failure. The benefit of eplerenone following acute myocardial infarction (MI) is limited to administration within 3 to 6 days post-MI. Aldosterone antagonists have been shown to lower the incidence of sudden cardiac death and to reduce proteinuria. In the setting of heart failure, long acting loop diuretics azosemide and torasemide are more effective in improving heart failure outcomes than the far more commonly used short acting furosemide. Evening dosing of diuretics appears to lower CVEs relative to morning dosing. In conclusion, diuretics are a diverse class of drugs that remain extremely important in the management of hypertension and hypervolemic states.
The Transmission of Unconventional Monetary Policy in UK Government Debt Markets

Through its quantitative easing programme the Bank of England has looked to manage the supply of nominal UK government securities in order to lower interest rates. In doing so it has removed more than 25 per cent of the overall supply of those securities from the publicly accessible market. The benchmark New Keynesian model suggests this should only have an impact on interest rates insofar as it affects expectations of future policy rates, whilst alternative theoretical frameworks imply a direct effect of changes in supply onto yields. Our aim is to test for the existence of these potential transmission mechanisms. We find empirical evidence to support the existence of both channels. Our analysis suggests the Bank's quantitative easing programme reduced yields by around 25 basis points through the supply channel alone. Importantly, we find that such supply effects have remained significant in recent years, suggesting that as quantitative easing is unwound the increase in publicly available supply will put upward pressure on interest rates. Lastly we highlight the monetary-fiscal interaction inherent in our result and discuss some of the issues it raises for policymakers.
Ethical Leadership Views from Tamil Classical Literature - With Reference to Thirukural

With increasing incidents of fraud, scandals, corruption on global level, a need is felt to create ethical organization. To create ethical organization, an ethical leadership at the top is needed. Top manager’s actions always provide a blueprint for what a firm’s corporate culture must be. Company’s important requirement on top is integrity, clear ethical values and standards. To maintain such ethical values and standards, corporate leaders should have higher moral development and ethical reasoning. Higher moral awareness is essential in order to achieve ethical organization standard. During current years, demand for ethics training and ethical workshop are increasing among top US, European corporations. Moreover some professional institutions like AICPA (American institute of Certified Public accountant), IMA (Institute of Management accountants), and IIA (Institute of Internal auditors) etc have introduced Ethics course as primary requirement for all the members. As corporations embark on global market for competition, demands for global ethical standard are expanding, instantly leading to more ethical literatures and researches.Various literatures preaching ethical values and moral living have been found in classical Tamil language. Among them one of the most oldest famous literatures which received world class scholar’s appreciation and additionally being translated into 30 different world languages is none other than “Thirukural”. This literature was crowned as one of the oldest ethical literature, which subscribes to the First Sangam Corpus. Mahatma Gandhi (Father of our nation) has commented this literature as a book of moral life. Several other western scholars also made the same remarks on such literature. In this study researcher tries to correlate Thirukural’s with that of contemporary ethical management theories, concepts and principles. Comparative study will be adapted with Thirukural’s meaning and interpretation with that of ethical management principles. Researcher will identify those views, definition, context which significantly correlates with that of contemporary thoughts and will be presented in the study. This research will explore traits and characters of ethical leadership.
EFFECT OF FOLIAR FERTILIZERS ON PHYSIOLOGICAL CHARACTERISTICS OF POTATO

Limited information is available on physiological response of potato (Solanum tuberosum L.) to the application of foliar fertilizers. Therefore, the aim of this study was to determine the effect of three commercial foliar fertilizers (EPSO Microtop, Megagreen and Drin) compared with control (without foliar fertilizer) on the intensity of photosynthesis, concentration of photosynthetic pigments in potato leaves and tuber dry matter yield at various intervals after planting. Greenhouse experiment was conducted during two growing seasons (2006 and 2007), which were characterized by higher than optimum temperatures. Foliar fertilizers were applied five times during vegetation in ten-day intervals starting at tuber initiation phase. Control plants achieved higher intensity of photosynthesis at tuber initiation phase (50 and 55 days after planting) in comparison to all foliar treatments. In all other days after planting, control and foliar treatments had similar intensity of photosynthesis. Application of foliar fertilizers did not increase the concentration of chlorophyll a and chlorophyll b in potato leaves and the aboveground dry matter yield. The highest tuber dry matter yield under conditions of higher than optimum temperature was obtained with the foliar fertilizer Megagreen, which contains calcium.