Miracle-dz/UniFAR-FTUs huggingface dataset:
Participatory Design for Security-Related User Interfaces

In this short paper, we explore the advantages of using Participatory Design (PD) to improve security-related user interfaces. We describe a PD method that we applied to actively involve users in creating new SSL warning messages. Supported by a designer, participants tapped into their experiences with existing warnings and created improved dialogs in workshop sessions. The process resulted in a set of diverse new warnings, showing multiple directions that the design of this warning can take. Applying PD lets participants engage more with the subject matter and thus create nuanced designs. Overall, our exploration suggests that PD can provide a suitable, versatile, and simple set of methods that support the creation of design ideas for security- related user interfaces. Users are empowered to critically appraise and adapt security measures that they come into contact with in their everyday life on their own. In the past decade, it has been commonly accepted that IT security measures for end-users need to be designed in a way that users can understand and apply them without unwarranted effort. However, improvements of user interface design for security measures described in previous research were often achieved by experts making educated guesses, based on experiences with users and the results of user studies. This form of design process has limitations, as it is dependent on both the quality of the collected data and experiences as well as the ingenuity of the designer. In this short paper, we propose to take the generation of design ideas one step further by directly integrating end users into the design process of security measures, instead of only benefiting from their experiences indirectly. Through such a deeper involvement of the target audience, the quality of the gathered insights can be improved and even the smallest aspects of a security system can be more easily addressed, compared to iteratively eliciting opinions through formal studies and usability evaluations. This approach is known as Participatory Design (PD) in other HCI
IN VITRO EVALUATION OF LARVAL AGE AND DOSE OF VIRUS- INOCULUM ON MORTALITY AND NPV-YIELD FROM HELICOVERPA ARMIGERA HUBNER

Four larval instars viz. II nd ,III rd ,IV th & V th were fed on diet treated with four different concentrations i.e. 1x10 8 , 1x10 7 , 1x10 6 , 1x10 5 POB/ml to evaluate highest mortality and maximum viral yield. Findings suggest that Ha-NPV should be applied to III rd instar larvae in vitro to achieve high larval mortality (78.33 %) and maximum viral yield (4.319 x10 9 POB/g of cadavar) at 1x10 7 ml dose inoculum. Mortality percentage reduced with a corresponding
Current-induced spin–orbit torques

The ability to reverse the magnetization of nanomagnets by current injection has attracted increased attention ever since the spin-transfer torque mechanism was predicted in 1996. In this paper, we review the basic theoretical and experimental arguments supporting a novel current-induced spin torque mechanism taking place in ferromagnetic (FM) materials. This effect, hereafter named spin–orbit (SO) torque, is produced by the flow of an electric current in a crystalline structure lacking inversion symmetry, which transfers orbital angular momentum from the lattice to the spin system owing to the combined action of SO and exchange coupling. SO torques are found to be prominent in both FM metal and semiconducting systems, allowing for great flexibility in adjusting their orientation and magnitude by proper material engineering. Further directions of research in this field are briefly outlined.
Clinical outcome and monitoring of minimal residual disease in patients with acute lymphoblastic leukemia expressing the MLL/ENL fusion gene

We analyzed 12 MLL/ENL positive ALL patients consecutively diagnosed between 1999 and 2009. The MLL/ENL fusion was identified in 4/150 (2.6%), 8/993 (0.8%), and 0/70 of pediatric, adult, and elderly patients, respectively. Eight patients had a WBC count >50 × 109/L. Ten cases had an evaluable immunophenotyping. A B or T precursor ALL occurred in 7 and 3 patients, respectively. Eleven/12 patients (92%) achieved CR. At 48 months, overall survival and event‐free survival rates were 73.3% and 67%, respectively. At CR, a parallel RT‐PCR evaluation of the MLL/ENL expression was available in 5 cases. Of these latter, 2 tested MLL/ENL‐negative and 3 positive. The minimal residual disease molecular monitoring showed that MLL/ENL status did not correlate with outcome. In fact, all the 2 PCR‐negative and 1 of the 3 PCR‐positive cases relapsed. Further, a MLL/ENL expression, not preceding a relapse, was detected several times during the follow‐up of five long‐survivors. In conclusion, also in adults, the MLL/ENL fusion identifies a rare leukemic entity with a favorable prognosis. The observed inconsistency between the clinical cure and the presence of detectable MLL/ENL transcript suggests the existence of a MLL/ENL‐expressing “preleukemia” stem cells, similar to what demonstrated for the AML1/ETO‐positive leukemia setting. Am. J. Hematol. 2011. © 2011 Wiley‐Liss, Inc.
Do adult patients with phenylketonuria improve their quality of life after introduction/resumption of a phenylalanine‐restricted diet?

Aim: To evaluate the possible influence of dietary treatment on the quality of life of adult patients with PKU (phenylketonuria) following late introduction or resumption of a Phe‐restricted diet. Methods: Fifteen adult patients with classical PKU (10F, 5M; mean age: 27.5 y, range: 16.4–37.5 y) were selected for the study. These patients had either resumed a restricted diet after a period of discontinuation, or were placed on a restricted diet after late diagnosis. All of them were interviewed about their quality of life using a 24‐item questionnaire. Results: The index of dietary control was poor (median Phe: 954 μmol/L) in 8/15 patients, regular (Phe: 514 μmol/L) in 4/15 and good (Phe: 354 μmol/L) in 3/15 patients. Fifty‐three percent of patients reported that their state of health was very good, 47% described it as good, and 40% felt that their present health on‐diet was better than it had been off‐diet; 53% believed that they were calmer, quieter and less easily upset and 40% were more alert and were more able to maintain attention while on‐diet. Thirty‐three percent of the patients felt happier, and 27% felt more vital; 20% thought that they were less impulsive and aggressive, and that they were now less argumentative than before. Sixty percent of the patients felt that their quality of life had improved on‐diet compared with the situation off‐diet.
Sailing on Friday: Developing the Link Between Safety Culture and Performance in Safety-Critical Systems

As large-scale organizations and systems become more complex and difficult to understand, and with the notable failure of organizational practices to prevent disaster in safety-critical systems, interest in identifying leading indicators (LI) of adverse events in safety-critical settings has increased. This paper examines the question of how to provide early warning of adverse events to groups in complex safety-critical settings by understanding the connection between safety culture and performance. Significant safety factors that were correlated with safety performance were identified as LIs of safety, using safety culture survey data from three industry partners gathered over a two-year period. Complementary techniques suggest further use of multiple analysis techniques in order to understand the structure, variance, and power of the identified LIs, as well as to provide validation methods for the results.
Large time out-of-equilibrium dynamics of a manifold in a random potential.

We study the out-of-equilibrium dynamics of an elastic manifold in a random potential using mean-field theory. We find two asymptotic time regimes: (i) stationary dynamics; (ii) slow aging dynamics with violation of equilibrium theorems. We obtain an analytical solution valid for all large times with universal scalings of two-time quantities with space. A nonanalytic scaling function crosses over to ultrametricity when the correlations become long range. We propose procedures to test numerically or experimentally the extent to which this scenario holds for a given system.
Functional Analysis of nsP3 Phosphoprotein Mutants ofSindbisVirus

ABSTRACT Alphavirus nsP3 phosphoprotein is essential for virus replication and functions initially within polyprotein P123 or P23 components of the short-lived minus-strand replicase, and upon polyprotein cleavage, mature nsP3 likely functions also in plus-strand synthesis. We report the identification of a second nsP3 mutant from among the A complementation group of Sindbis virus (SIN) heat-resistant strain, ts RNA-negative mutants. The ts138 mutant possessed a change of G4303 to C, predicting an Ala68-to-Gly alteration that altered a conserved His-Ala-Val tripeptide in the ancient (pre-eukaryotic),“ X” or histone 2A phosphoesterase-like macrodomain that in SIN encompasses nsP3 residues 1 to 161 and whose role is unknown. We undertook comparative analysis of three nsP3 N-terminal region mutants and observed (i) that nsP3 and nsP2 functioned initially as a single unit as deduced from complementation analysis and in agreement with our previous studies, (ii) that the degree of phosphorylation varied among the nsP3 mutants, and (iii) that reduced phosphorylation of nsP3 correlated with reduced minus-strand synthesis. The most striking phenotype was exhibited by ts4 (Ala268 to Val), which after shift to 40°C made significantly underphosphorylated P23/nsP3 and lost selectively the ability to make minus strands. After shift to 40°C, mutant ts7 (Phe312 to Ser) made phosphorylated P23/nsP3 and minus strands but failed to increase plus-strand synthesis. Macrodomain mutant ts138 was intermediate, making at 40°C partially phosphorylated P23/nsP3 and reduced amounts of minus strands. The mutants were able to assemble their nsPs at 40°C into complexes that were membrane associated. Our analyses argue that P23/P123 phosphorylation is affected by macrodomain and Ala268 region sequences and in turn affects the efficient transcription of the alphavirus genome.
Development of a Chlamydia trachomatis vaccine for urogenital infections: novel tools and new strategies point to bright future prospects

ABSTRACT Introduction: The “cloaked“ bacterial pathogen that is Chlamydia trachomatis continues to cause sexually transmitted infections (STIs) that adversely affect the health and well-being of children, adolescents and adults globally. The reproductive disease sequelae follow unresolved or untreated chronic or recurrent asymptomatic C.trachomatis infections of the lower female genital tract (FGT) and can include pelvic pain, pelvic inflammatory disease (PID) and ectopic pregnancy. Tubal Factor Infertility (TFI) can also occur since protective and long-term natural immunity to chlamydial infection is incomplete, allowing for ascension of the organism to the upper FGT. Developing countries including the WHO African (8.3 million cases) and South-East Asian regions (7.2 million cases) bear the highest burden of chlamydial STIs. Areas covered: Genetic advances for Chlamydia have provided tools for transformation (including dendrimer-enabled transformation), lateral gene transfer and chemical mutagenesis. Recent progress in these areas is reviewed with a focus on vaccine development for Chlamydia infections of the female genital tract. Expert commentary: A vaccine that can elicit immuno-protective responses whilst avoiding adverse immuno-pathologic host responses is required. The current technological advances in chlamydial genetics and proteomics, as well as novel and improved adjuvants and delivery systems, provide new hope that the elusive chlamydial vaccine is an imminent and realistic goal.
Un rasgo fonologico de la lengua espanola

En el orden labial, /b/ se distingue de /p/ y /f/ por la marca de sonoridad, /p/ de /f/ por la oclusidn. La misma situaci6n existe con los fonemas dentales y velares. En la serie palatal, /6/ se diferencia de /J/ por la ausencia de sonoridad, y de /s/ por la oclusidn. Respecto a /j/ y /s/, "ofrece una realizaci6n fon6tica muy distinta para considerarlos en oposici6n proporcional de sonoridad" (p4g. 176). N obstante, e el cuadro de rasgos istintivos empleado por Alarcos, la sonoridad, o la tensi6n articulatoria, parecen ser las (inicas caracteristicas fon6ticas que podrian diferenciar /j/ y /s/. Las consonantes implosivas de las palabras apto y obtiene, ritmo y admira, pueden ser fricativas u oclusivas, sonoras o sordas, segin la tensi6n articulatoria con que se pronuncien.2 Basandose en tales vacilaciones de las consonantes obstruyentes al final de silaba, E. Alarcos (pAg. 184) y A. Alons 3 pensaron que la sonoridad, como asgo ertinente, opera en la lengua espafiola s lamente al principio de silaba. En posicidn implosiva, /p, t, k/ y /b, d, g/ se neutralizan. Alarcos y Alonso estaban en lo cierto
The Cdc42 Effector IRSp53 Generates Filopodia by Coupling Membrane Protrusion with Actin Dynamics*

The Cdc42 effector IRSp53 is a strong inducer of filopodia formation and consists of an Src homology domain 3 (SH3), a potential WW-binding motif, a partial-Cdc42/Rac interacting binding region motif, and an Inverse-Bin-Amphiphysins-Rvs (I-BAR) domain.We show that IRSp53 interacts directly with neuronal Wiskott-Aldrich syndrome protein (N-WASP) via its SH3 domain and furthermore that N-WASP is required for filopodia formation as IRSp53 failed to induce filopodia formation in N-WASP knock-out (KO) fibroblasts. IRSp53-induced filopodia formation can be reconstituted in N-WASP KO fibroblasts by full-length N-WASP, by N-WASPΔWA (a mutant unable to activate the Arp2/3 complex), and by N-WASPH208D (a mutant unable to bind Cdc42). IRSp53 failed to induce filopodia in mammalian enabled (Mena)/VASP KO cells, and N-WASP failed to induce filopodia when IRSp53 was knocked down with RNA interference. The IRSp53 I-BAR domain alone induces dynamic membrane protrusions that lack actin and are smaller than normal filopodia (“partial-filopodia”) in both wild-type N-WASP and N-WASP KO cells. We propose that IRSp53 generates filopodia by coupling membrane protrusion through its I-BAR domain with actin dynamics through SH3 domain binding partners, including N-WASP and Mena.
Cognitive function and distress after common whiplash injury

Introduction – In a prospective study 29 patients fulfilled the criteria of Whiplash‐Associated Disorders grade III in the Quebec classification. Material and methods – One month postinjury, computerized neuropsychological tests, a clinical interview and the symptom checklist SCL‐90‐R were administered. Three whiplash scales were extrapolated from SCL‐90‐R: pain, subjective cognitive difficulties and sleep disorders. SCL‐90‐R was repeated 6 months later. Results – One month after the accident, 85% of the patients had resumed work. Subjective cognitive disturbances, however, were frequent but unrelated to test performances, which were within the normal range. Patients reporting stressful life events unrelated to the injury had more symptoms and elevated levels of distress on all SCL‐90‐R syndrome scales. At follow‐up their distress was unchanged, and subjective cognitive function had deteriorated. Conclusion – Stressful life events unrelated to the accident and a high level of distress 1 month postinjury may augment the risk of “late whiplash syndrome”. Reassessment 3–6 weeks postinjury as recommended by the Quebec Task Force should include assessment of complicating social factors and a psychological symptom checklist.
On the number of leaves of a euclidean minimal spanning tree

Let Vk,n be the number of vertices of degree k in the Euclidean minimal spanning tree of Xi , , where the Xi are independent, absolutely continuous random variables with values in Rd. It is proved that n –1 Vk,n converges with probability 1 to a constant α k,d. Intermediate results provide information about how the vertex degrees of a minimal spanning tree change as points are added or deleted, about the decomposition of minimal spanning trees into probabilistically similar trees, and about the mean and variance of Vk,n.
Second-line and rescue therapies for Helicobacter pylori eradication in clinical practice.

BACKGROUND AND AIMS A levofloxacin-based triple therapy and a rifabutin-based regimen are advised as second-line and rescue therapies in the current Italian guidelines for H. pylori eradication. However, no data are available for the efficacy of these treatments in clinical practice. METHODS A total of 86 consecutive patients who failed a standard, first-line, triple therapy for H. pylori infection were treated with a 10-day triple therapy including omeprazole 20 mg, amoxycillin 1 g, and levofloxacin 250 mg or 500 mg, each given twice daily. Eradication failure patients received a 10-day rescue therapy with omeprazole 20 mg, amoxycillin 1 g, and rifabutin 150 mg, each given twice daily. A further therapeutic attempt was performed with a 14-day, high-dose dual therapy (esomeprazole 40 mg and amoxicillin 1 g, each thrice daily). RESULTS Following the second-line therapy, H. pylori infection was cured in 76.4% (95% CI = 67.8-85.0) and 79.5% (95% CI = 70.8-88.2) at intention-to-treat (ITT) and per-protocol (PP) analysis, respectively. After the rescue therapy, bacterial eradication was achieved in 84.6% (95% CI = 65-100). Two patients with persistent infection were successfully cured with the high-dose dual therapy. CONCLUSION The efficacy of levofloxacin-based second-line therapy seems to be decreasing, whilst rescue therapy with rifabutin would appear a valid third-line therapy, and a high-dose dual therapy may be used as a further rescue therapy.
Are spirituality and religiosity resources for patients with chronic pain conditions?

OBJECTIVE We studied whether or not spirituality/religiosity is a relevant resource for patients with chronic pain conditions, and to analyze interrelations between spirituality/religiosity (SpREUK Questionnaire; SpREUK is an acronym of the German translation of "Spiritual and Religious Attitudes in Dealing with Illness"), adaptive coping styles that refer to the concept of locus of disease control (AKU Questionnaire; AKU is an acronym of the German translation of "Adaptive Coping with Disease"), life satisfaction, and appraisal dimensions. PATIENTS In a multicenter cross-sectional study, 580 patients with chronic pain conditions were enrolled. RESULTS We found that the patients relied on both external powerful sources of disease control and on internal powers and virtues, while Trust in Higher Source (intrinsic religiosity) or Illness as Chance (reappraisal) were valued moderately; Search for Meaningful Support/Access (spiritual quest orientation) was of minor relevance. Stepwise regression analyses revealed that the internal sources of disease control, such as Conscious and Healthy Way of Living and Positive Attitudes, were (apart from the religious denomination) the strongest predictors of patients' reliance on spirituality/religiosity. Both behavioral styles were rated significantly lower in patients who regarded themselves as neither religious nor spiritual. Positive disease interpretations such as Challenge and Value were clearly associated with a spiritual quest orientation and intrinsic religiosity. CONCLUSION The associations between spirituality/religiosity, positive appraisals. and internal adaptive coping strategies indicate that the utilization of spirituality/religiosity goes far beyond fatalistic acceptance, but can be regarded as an active coping process. The findings support the need for further research concerning the contributions of spiritual coping in adjustment to chronic pain.
Occult pneumothoraces in patients with penetrating trauma: Does mechanism matter?

BACKGROUND Supine anteroposterior (AP) chest radiography is an insensitive test for detecting posttraumatic pneumothoraces (PTXs). Computed tomography (CT) often identifies occult pneumothoraces (OPTXs) not diagnosed by chest radiography. All previous literature describes the epidemiology of OPTX in patients with blunt polytrauma. Our goal was to identify the frequency of OPTXs in patients with penetrating trauma. METHODS All patients with penetrating trauma admitted over a 10-year period to Grady Memorial Hospital with a PTX were identified. We reviewed patients' thoracoabdominal CT scans and corresponding chest radiographs. RESULTS Records for 1121 (20%) patients with a PTX (penetrating mechanism) were audited; CT imaging was available for 146 (13%) patients. Of these, 127 (87%) had undergone upright chest radiography. The remainder (19 patients) had a supine AP chest radiograph. Fifteen (79%) of the PTXs detected on supine AP chest radiographs were occult. Only 10 (8%) were occult when an upright chest radiograph was used (p < 0.001). Posttraumatic PTXs were occult on chest radiographs in 17% (25/146) of patients. Fourteen (56%) patients with OPTXs underwent tube thoracostomy, compared with 95% (115/121) of patients with overt PTXs (p < 0.001). CONCLUSION Up to 17% of all PTXs in patients injured by penetrating mechanisms will be missed by standard trauma chest radiographs. This increases to nearly 80% with supine AP chest radiographs. Upright chest radiography detects 92% of all PTXs and is available to most patients without spinal trauma. The frequency of tube thoracostomy use in patients with overt PTXs is significantly higher than for OPTXs in blunt and penetrating trauma.
Impact of IMF Assistance on Economic Growth Revisited

We investigate the effect of IMF assistance on economic growth in a broad panel of countries. We argue that countries are likely self-select into seeking IMF involvement based on their economic performance. We control for such endogeneity by means of instrumental variables. Our findings indicate that the contemporaneous effect of the IMF involvement is insignificant while the lagged effect is positive. The 2SLS effect is larger than the OLS one, indicating that the latter is downward biased.
Design of an Indoor Self-Positioning System for the Visually Impaired - Simulation with RFID and Bluetooth in a Visible Light Communication System

After a public experiment of the indoor guidance system using FLC (fluorescent light communication), we found that FLC provides a promising medium for the installation of a guidance system for the visually impaired. However, precise self-positioning was not satisfactorily achieved. In this article, we propose a new self-positioning method, one that uses a combination of RFID (radio-frequency identification), Bluetooth and FLC. We analyzed the situation and developed a model that combined the three communication modes. Then we performed a series of experiments and get some results in the first step.
[Preliminary study on the mechanisms of acupuncture in promoting embryo implantation in rats].

OBJECTIVE To observe the influence of acupuncture on embryo implantation in rat model of embryo implantation dysfunction, and to primarily explore its possible mechanisms. METHODS Pregnant rats were randomly allocated into the control group, the model group and the acupuncture group. The pregnancy rate and average number of blastocyst were observed, the serum levels of estrodiol (E2), progesterone (P4) and prolactin (PRL) were detected by RIA, and the protein and mRNA expression of progesterone receptor (PR) and prolactin receptor (PRLR) in endometrial tissue of implantation site were determined using immunohistochemical assay and RT-PCR respectively. RESULTS The pregnancy rate and average number of blastocyst were significantly higher in the acupuncture group than those in the control group respectively (P <0.01). The serum levels of P4 and PRL as well as the protein and mRNA expression levels of PR and PRLR in the model group were significantly lower than those in the other two groups (P<0.05). CONCLUSION Acupuncture can promote embryo implantation in rats to a certain degree, and its mechanism might be related with the effects of acupuncture in mediating the sexual hormone levels and the receptor expression of rats.