Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation tool for direct load control of electric vehicle charging and water heating systems

Due to growing concerns for the environment, the electrification of the transport sector is considered as one of the most promising methods for reducing greenhouse gas emissions. Increased penetration of electric vehicles (EVs) will create a new demand for electricity within the residential distribution network, which can negatively impact the grid if the EV loads are left unmanaged. This could lead to expensive upgrades of the distribution network. The primary aim of this research is to develop a tool to estimate the impact of EVs on the distribution network, which will then allow users of the tool to make informed decisions regarding electrical infrastructure upgrades. The tool combines direct load control (DLC) of EV and hot water loads to estimate the maximum level of EV penetration possible without system upgrades.
Genotoxic Hazard and Cellular Stress in Pediatric Patients Treated for Psoriasis with the Goeckerman Regimen

Abstract: The Goeckerman regimen (GR) represents a local treatment of psoriasis and includes topical dermal application of crude coal tar (containing polycyclic aromatic hydrocarbons) and exposure to UV‐irradiation. The aim of the study was to evaluate contribution of GR to genotoxic risk and cellular stress in pediatric patients who represent a sensitive population subgroup. Genotoxic risk (42 patients) was evaluated by using chromosomal aberrations (CA) in peripheral lymphocytes. Cellular stress (26 patients) was assessed by using heat shock proteins (Hsp70). All indicators were determined in blood samples collected before GR and immediately after GR. Decreasing of psoriasis area and severity index (PASI) score indicated higher likelihood of GR (p < 0.001). Significantly increased CA (p < 0.001) and Hsp70 (p < 0.05) indicated higher genotoxic risk and cellular stress in sensitive pediatric patients, immediately after GR.
A novel signaling molecule, p130, forms stable complexes in vivo with v‐Crk and v‐Src in a tyrosine phosphorylation‐dependent manner.

p47v‐crk (v‐Crk), a transforming gene product containing Src homology (SH)‐2 and ‐3 domains, induces an elevated level of tyrosine phosphorylation of several cellular proteins. Among these proteins, a 125‐135 kDa protein (p130) shows marked phosphorylation at tyrosines and tight association with v‐Crk, suggesting a direct signal mediator of v‐Crk. Here we report the molecular cloning of rat p130 by immunoaffinity purification. The p130 is a novel SH3‐containing signaling molecule with a cluster of multiple putative SH2‐binding motifs of v‐Crk. Immunochemical analyses revealed that p130 is highly phosphorylated at tyrosines during transformation by p60v‐src (v‐Src), as well as by v‐Crk, forming stable complexes with these oncoproteins. The p130 behaves as an extremely potent substrate of kinase activity included in the complexes and it is a major v‐Src‐associated substrate of the Src kinase by partial peptidase mapping. Subcellular fractionation demonstrated that the cytoplasmic p130 could move to the membrane upon tyrosine phosphorylation. The p130 (designated Cas for Crk‐associated substrate) is a common cellular target of phosphorylation signal via v‐Crk and v‐Src oncoproteins, and its unique structure indicates the possible role of p130Cas in assembling signals from multiple SH2‐containing molecules.
Novel Nucleotide Sequence Motifs That Produce Hotspots of Meiotic Recombination in Schizosaccharomyces pombe

In many organisms, including yeasts and humans, meiotic recombination is initiated preferentially at a limited number of sites in the genome referred to as recombination hotspots. Predicting precisely the location of most hotspots has remained elusive. In this study, we tested the hypothesis that hotspots can result from multiple different sequence motifs. We devised a method to rapidly screen many short random oligonucleotide sequences for hotspot activity in the fission yeast Schizosaccharomyces pombe and produced a library of ∼500 unique 15- and 30-bp sequences containing hotspots. The frequency of hotspots found suggests that there may be a relatively large number of different sequence motifs that produce hotspots. Within our sequence library, we found many shorter 6- to 10-bp motifs that occurred multiple times, many of which produced hotspots when reconstructed in vivo. On the basis of sequence similarity, we were able to group those hotspots into five different sequence families. At least one of the novel hotspots we found appears to be a target for a transcription factor, as it requires that factor for its hotspot activity. We propose that many hotspots in S. pombe, and perhaps other organisms, result from simple sequence motifs, some of which are identified here.
Experimental evidence showing that no mitotically active female germline progenitors exist in postnatal mouse ovaries

It has been generally accepted for more than half a century that, in most mammalian species, oocytes cannot renew themselves in postnatal or adult life, and that the number of oocytes is already fixed in fetal or neonatal ovaries. This assumption, however, has been challenged over the past decade. In this study, we have taken an endogenous genetic approach to this question and generated a multiple fluorescent Rosa26rbw/+;Ddx4-Cre germline reporter mouse model for in vivo and in vitro tracing of the development of female germline cell lineage. Through live cell imaging and de novo folliculogenesis experiments, we show that the Ddx4-expressing cells from postnatal mouse ovaries did not enter mitosis, nor did they contribute to oocytes during de novo folliculogenesis. Our results provide evidence that supports the traditional view that no postnatal follicular renewal occurs in mammals, and no mitotically active Ddx4-expressing female germline progenitors exist in postnatal mouse ovaries.
Efecto de año, bimestre y número de parto de la cerda en el tamaño y peso de la camada al nacer y al destete en una granja comercial.

Introduccion. Investigaciones realizadas en varios paises, han demostrado que la produccion de la hembra esta influenciada por el ano o epoca de parto y por el numero de parto de las marranas. Este efecto se manifiesta en los distintos indicadores de produccion, como fertilidad, tamano y peso de la camada al nacer y al destete. Conocer la magnitud del efecto del numero de parto en los rasgos predestete, es de gran importancia para tomar decisiones sobre el sistema de desecho y reemplazo de la piara, lo cual conduciria a la toma de decisiones mas adecuadas al sistema de manejo en la granja de interes. El objetivo de este estudio fue determinar los efectos de ano, bimestre y numero de parto de la marrana en algunos indicadores predestete de una granja porcina del estado de Yucatan, Mexico. Material y metodos. Se analizaron los registros de dos anos de produccion de una granja localizada en la zona centro del estado de Yucatan, con un clima tropical subhumedo. Datos de 8570 y 7841 tamanos de camada y promedios de peso de los lechones al nacimiento y al destete, respectivamente, fueron utilizados. La informacion mensual de las marranas se combino para formar seis bimestres. El tamano de camada al nacer se definio como el numero total de lechones al nacer (vivos y muertos). El modelo que describio a las variables de respuesta incluyo los efectos fijos de ano de parto, bimestre de parto y numero de parto de la marrana. Resultados. Las medias generales y desviaciones estandares para el tamano de la camada al nacer (TCN), numero de lechones nacidos vivos (NLV), promedio de peso de los lechones al nacer (PLN), numero de lechones destetados (NLD) y peso promedio de los lechones al destete (PLD) fueron de 10.99±2.93 lechones, 10.24±2.83 lechones, 1.58±0.25 kg, 9.44±1.11 lechones y 5.81±0.89 kg, respectivamente. Se encontraron efectos (p‹0.05) de ano, bimestre y numero de parto en el TCN y NLV, pero no del ano de parto en PLN. Con respecto al NLD se encontro efecto de ano y bimestre de parto (p‹0.05), pero no del numero de parto (p›0.05); mientras que el PLD se vio influenciado por los tres factores estudiados (p‹0.05). En general los indicadores productivos para el ano de 1995 fueron mejores que para 1994. El efecto de bimestre fue significativo (p‹0.05) sobre todas las variables de respuesta estudiadas, sin embargo, no se observo ninguna tendencia. Las marranas de primer y segundo parto tuvieron camadas con pesos menores que aquellas con 3 o 4 partos. Sin Discusion. Los PLN y PLD estuvieron influenciados por el numero de parto de las marranas; mientras que el ano y bimestre de nacimiento fueron importantes fuentes de variacion para todas las variables de respuesta estudiadas. embargo, al destete no se encontro diferencia (p›0.05) en las medias de los tamanos de camada y con respecto a los PLD las marranas de primer y cuarto parto tuvieron los promedios mas bajos (p‹0.05).
Proposição de metodologia e de modelo preditivo para avaliação da sensação térmica em espaços abertos em Curitiba

O planejamento ou a readequacao urbana de espacos abertos sao capazes de promover a melhoria das condicoes termicas exteriores, e assim, influenciar qualitativamente o uso de espacos abertos. Neste contexto, esta pesquisa tem como objetivo analisar a sensacao termica da populacao de Curitiba e propor um modelo de predicao de sensacao termica adequado as condicoes climaticas locais. Os locais de estudo sao ruas de pedestres da Rua XV de Novembro e cercanias. Foram realizados 15 levantamentos de campo, sendo 14 dias no periodo entre janeiro e agosto de 2009 e um dia em junho de 2010, totalizando 15 situacoes urbanas distintas. Os levantamentos ocorreram entre 10h00 e 15h00 em dias de semana e foram monitorados dados climaticos e levantados dados pessoais, com o uso de questionarios. A metodologia utilizada compreendeu quatro etapas: analise da relacao entre as caracteristicas urbanas e a sensacao termica; analise da sensacao termica real, a partir dos dados coletados; analise da sensacao termica por meio dos indices PMV, PET e UTCI; e proposicao de um modelo preditivo de sensacao termica para Curitiba. Da analise dos atributos urbanos e sua relacao com as variaveis climaticas e a sensacao termica, concluiu-se que a orientacao do cânion e o perfil vertical das fachadas sao importantes para compreender o comportamento das variaveis climaticas e para propor sugestoes que melhorem o conforto termico no ambiente urbano. A analise dos indices PMV, PET e UTCI mostrou a necessidade de calibracao destes indices para a avaliacao da sensacao termica da populacao de Curitiba. Ao analisar as respostas de sensacao termica e as variaveis climaticas verificou-se que as tres categorias de sensacao termica se misturam entre si, nao havendo clara distincao entre o grupo de conforto e os de desconforto para o frio e para o calor, o que dificulta a definicao de faixas climaticas de conforto termico para Curitiba. Em relacao aos dois metodos estatisticos utilizados para a definicao do modelo de predicao, a Funcao Discriminante Linear (FDL) apresentou melhor desempenho que o Modelo de Regressao Logistico (MRL), tendo taxa total de acerto de 53%, se mostrando adequada para a avaliacao da sensacao termica da populacao analisada.
Expression of complexin I and II mRNAs and their regulation by antipsychotic drugs in the rat forebrain

Complexin (cx) I and II are homologous synaptic protein genes which are differentially expressed in mouse and human brain and differentially affected in schizophrenia. We characterized the distribution of cx I and II mRNAs in rat forebrain and examined whether their abundance, or the transcript of the synaptic marker synaptophysin, is affected by 14 days' administration of antipsychotic drugs (haloperidol, chlorpromazine, risperidone, olanzapine, or clozapine). Cx I mRNA predominated in medial habenula, medial septum‐diagonal band complex, and thalamus, whereas cx II mRNA was more abundant in most other regions, including isocortex and hippocampus. Within the hippocampus, cx I mRNA was primarily expressed by interneurons and cx II mRNA by granule cells and pyramidal neurons. Localized cx II mRNA signal was seen in the dentate gyrus molecular layer, suggestive of its transport into granule cell dendrites. Antipsychotic treatment produced selective, modest effects on cx mRNA expression. Cx I mRNA was elevated by olanzapine in dorsolateral striatum and frontoparietal cortex, while the abundance of cx II mRNA relative to cx I mRNA was decreased in both areas by olanzapine and haloperidol. Chlorpromazine increased cx II mRNA in frontoparietal cortex and synaptophysin mRNA in dorsolateral striatum. In summary, the data have implications both for understanding the effects of antipsychotic medication on synaptic organization, and for synaptic protein expression studies in patients treated with the drugs. Synapse 36:167–177, 2000. © 2000 Wiley‐Liss, Inc.
Approaches to Cognitive Modeling in Dynamic Systems Control

Much of human decision making occurs in dynamic situations where decision makers have to control a number of interrelated elements (dynamic systems control). Although in recent years progress has been made toward assessing individual differences in control performance, the cognitive processes underlying exploration and control of dynamic systems are not yet well understood. In this perspectives article we examine the contribution of different approaches to modeling cognition in dynamic systems control, including instance-based learning, heuristic models, complex knowledge-based models and models of causal learning. We conclude that each approach has particular strengths in modeling certain aspects of cognition in dynamic systems control. In particular, Bayesian models of causal learning and hybrid models combining heuristic strategies with reinforcement learning appear to be promising avenues for further work in this field.
Lamination Frequencies as a Diagnostic for Horizontal Mixing in a 3D Transport Model

Abstract Ozone simulations are performed in an attempt to simulate laminar events with the frequency observed in balloon ozone sondes. The winds are taken from the Goddard Earth Observing System Data Assimilation System (GEOS DAS); the importance of horizontal and vertical resolution to production of lamina are investigated. A simulation with a high horizontal reolution (grid spacing 1° latitude by 1.25° longitude) and high vertical resolution (∼300 m grid spacing) isentropic model produces lamination frequencies close to the balloon sonde climatology near the polar vortex edge but exhibits too much lamination in the subtropics. This indicates that the GEOS DAS winds contain the information to produce laminar events, although such small-scale features are not manifest in the more commonly used 2° latitude by 2.5° longitude transport model, which uses the hybrid sigma-pressure vertical coordinate. The zonal average ozone tendencies due to horizontal mixing in the lamina-producing models are similar to the .
Modeling 3GPP LTE Advanced DRX Mechanism Under Multimedia Traffic

The discontinuous reception (DRX) mechanism is adopted in the Long Term Evolution Advanced (LTE-A) system as a core technology to lower the power consumption of user equipment. With the development of Mobile Internet, there is an increasing need to optimize the DRX parameter configuration to accommodate the mobile multimedia applications that exhibit self-similarity. In this letter, we model the LTE-A DRX mechanism under self-similar traffic based on a Discrete Time Semi-Markov Process. With our model, the power saving factor and the expectation of wake-up delay can be accurately estimated for a specific DRX parameter configuration. The accuracy of the proposed model is validated through comparison with simulation results.
Paternidade no Brasil: revisão sistemática de artigos empíricos

O objetivo deste estudo foi caracterizar a producao de artigos empiricos envolvendo o tema paternidade e sua contribuicao para o desenvolvimento infantil e para a familia, publicados entre 2000 e 2012 em revistas brasileiras indexadas nas bases IndexPsi, SciELO e PePSIC. Utilizaram-se os descritores “pai”, “paternidade” e “paterno”. Cem artigos foram analisados integralmente. Em 70% deles, os autores utilizaram analise qualitativa dos dados. Constatou-se a preferencia pelo metodo de levantamento de dados (60%) e pela entrevista como tecnica de coleta (47%). Dentre os temas investigados, destacam-se: gestacao, parto e pos-parto (25%), exercicio da paternidade (22%), desenvolvimento infantil (15%), adolescencia (14%) e concepcoes acerca do comportamento paterno (13%). Sugere-se que estudos futuros investiguem o pai em diferentes configuracoes e cenarios e o compartilhamento de funcoes na familia, integrando as abordagens quantitativa e qualitativa e envolvendo estudos longitudinais.
Modulation of the glucagon-dependent induction of phosphoenolpyruvate carboxykinase and tyrosine aminotransferase by arterial and venous oxygen concentrations in hepatocyte cultures.

Periportal and perivenous hepatocytes are heterogeneous as to their outfit with enzymes and subcellular structures. The influence of different physiological oxygen concentrations on gene expression was studied in primary cultures of adult rat hepatocytes. 1 In 24-cultures the activities of phosphoenolpyruvate carboxykinase andtyrosine aminotransferase, which are predominantly located in periportal cells, were increased by glucagons(0.1 μmol/1)within 4 h to higher levels under 13%(v/v)oxygen in the gas atmosphere (mimicking arterial oxygen concentrations)than under 6%(v/v)oxygen (mimicking venous oxygen concentrations). The increase was due to enzyme induction as indicated by its prevention with cycloheximide or actinomycin D and by direct immunochemical titration. 2 Half-maximal induction of phosphoenolpyruvate carboxykinase and tyrosine aminotransferase was obtained under high and low oxygen tensions with glucagons concentrations around 0.5 nmol/1. 3 The induction of phosphoenolpyruvate carboxykinase and tyrosine aminotransferase by glucagons showed a sigmoidal rather than a linear dependence on oxygen tension; the range of highest sensitivity was found to be between 8% and 11% oxygen(v/v). 4 The oxygen dependence of the induction of phosphoenolpyruvate carboxykinase and tyrosine aminotransferase was probably specific and did not reflect a general impairment of energy metabolism. In the hapatocytes cultured under 13% and 6% oxygen (v/v) a)the adenine nucleotide levels were essentially the same the energy charge being 0.89;(b)the oxygen consumption was similar, 2.42±0.10 and 2.27±0. 26μmol min −1wet weight −1; and (c)incorporation of [14] leucine into cellular protein as a measure of general protein synthesis amounted to 6.9 ±0.38 and 6.0 ± 0.4. nmol min −1mg DNA−1. The present results demonstrate that different physiological oxygen tensions can modulate the induction of liver enzymes and can thus contribute to the heterogeneity of hapatocytes.
Lupus panniculitis refractory to multiple therapies treated successfully with rituximab: A case report and literature review

dermal melanoma. Am. J. Surg. Pathol. 2010; 34: 216–22. 4. Falconieri G, Bacchi CE, Luzar B. Cutaneous clear cell sarcoma: report of three cases of a potentially underestimated mimicker of spindle cell melanoma. Am. J. Dermatopathol. 2012; 34: 619–25. 5. Protsenko SA, Semionova AI, Komarov YI et al. BRAFmutated clear cell sarcoma is sensitive to vemurafenib treatment. Invest. New Drugs 2015; 33: 1136–43. 6. Cornillie J, van Cann T, Wozniak A et al. Biology and management of clear cell sarcoma: state of the art and future perspectives. Expert Rev. Anticancer Ther. 2016; 16: 839–45.
Radiological Imaging and Intervention in Venous Thrombosis

Radiological imaging plays a central role in the diagnosis, and treatment, of deep venous thrombosis (DVT) in the upper and lower limb. The intention of this chapter is not to distract the reader with a detailed account of the physics behind generating ultrasound (US), computed tomography (CT) and MR (magnetic resonance) vascular imaging. This would demand a chapter in its own right, and this information can be readily found in textbooks. Instead, emphasis will be placed on the clinical indications for requesting imaging in the diagnosis of DVT, as well as the potential limitations of these modalities. This will be supplemented with a review of current evidence and guidelines, and examples of the common image findings. The latest advances in venous MR imaging will be discussed, as will the role of interventional radiology in the treatment of DVT. Finally, considering that it is now universally accepted that DVT and pulmonary embolus (PE) are essentially manifestations of the same disease – namely, venous thromboembolism (Moser et al., 1994) – the imaging and radiological management of PE will also be addressed.
Analysis of fractures of the proximal femur in the Jordanian population.

BACKGROUND Proximal femur fractures represent a challenging medical problem worldwide. In recent years numerous reports have documented a progressive increase in the incidence of hip fractures. In Jordan, this problem has not received sufficient attention, and to my knowledge, this is the first study to address the problem. OBJECTIVE To analyze the predisposing factors involved in the occurrence of proximal femur fractures seen at a major medical center in Jordan. METHODS A retrospective analysis was conducted of all patients admitted with hip fractures to King Hussein Hospital and the Royal Jordanian Rehabilitation Center at the King Hussein Medical Center over a 2 year period (1 January 1995 to 31 December 1996). We determined the associated chronic diseases and medications, mechanisms of injury, types of fractures and other circumstances in order to suggest preventive measures to decrease the incidence of this clinical problem. RESULTS We identified 216 cases of fracture: 43% occurred in people over the age of 80 years, 95% were due to low energy injuries (falls), and 69.5% occurred in females. Two or more co-morbid medical conditions were present in 70% of the cases. CONCLUSIONS Since fractures of the hip in the study population in Jordan occurred predominantly as low energy injuries in the elderly, preventive measures should focus on fall avoidance.
A 29.5 dBm class-E outphasing RF power amplifier with performance enhancement circuits in 45nm CMOS

A high efficiency class-E outphasing RF power amplifier is presented using a new passive combining circuit. A Power Enhancement Circuit (PEC) and an Efficiency Enhancement Circuit (EEC) are also proposed as part of the combiner that increase output power without violating reliability limits and improve efficiency at power back-off, respectively. The proposed power amplifier is designed in 45nm CMOS technology. Simulation results and measurement data are presented to demonstrate the performance of the proposed PA. The PA delivers 29.5 dBm peak output power at 2.4GHz with 46.76% drain efficiency at peak output power, 32.96% drain efficiency at 3 dB power back-off and 21.16% drain efficiency at 6 dB power back-off. Better than -50 dBc ACPR is obtained with 64-QAM LTE signal with 10MHz and 20MHz bandwidth. 21% average efficiency is obtained with LTE signal with 6 dB peak-to-average power ratio (PAPR).