Miracle-dz/UniFAR-FTUs huggingface dataset:
Complications of Insulin Pump Therapy: The Effect of Insulin Preparation

Complications of insulin infusion pump therapy include ketoacidosis related to interruption of insulin delivery and infected infusion sites. To determine if the type of insulin used in insulin pumps is a factor influencing these complications, we compared the occurrence of inflammation and infection at infusion sites and obstruction of infusion tubing in a 6-mo crossover study of 28 patients using two different insulin preparations. The use of buffered purified pork insulin was associated with less infusion site inflammation (P = 0.0039) and infusion set obstruction (P = 0.0215) than use of unbuffered beef-pork insulin. Infected infusion sites occurred less often with buffered pure pork insulin than with unbuffered beef-pork insulin, but the difference was not statistically significant. We conclude that the type of insulin selected for use in insulin pumps influences the occurrence of adverse reactions to insulin pump therapy: buffered purified pork insulin is associated with less infusion site inflammation and infusion set obstruction than unbuffered beef-pork insulin.
Objective detection of the central auditory processing disorder:A new machine learning approach

The objective detection of binaural interaction is of diagnostic interest for the evaluation of the central auditory processing disorder (CAPD). The /spl beta/-wave of the binaural interaction component in auditory brainstem responses has been suggested as an objective measure of binaural interaction and has been shown to be of diagnostic value in the CAPD diagnosis. However, a reliable and automated detection of the /spl beta/-wave capable of clinical use still remains a challenge. We propose a new machine learning approach to the detection of the CAPD that is based on adapted tight frame decompositions which are tailored for support vector machines with radial kernels. Using shift-invariant scale and morphological features of the binaurally evoked brainstem potentials, our approach provides at least comparable results to the /spl beta/-wave detection in view of the discrimination of subjects being at risk for CAPD and subjects being not at risk for CAPD. Furthermore, as no information from the monaurally evoked potentials is necessary, the measurement cost is reduced by two-thirds compared to the computation of the binaural interaction component. We conclude that a machine learning approach in the form of a hybrid tight frame-support vector classification is effective in the objective detection of the CAPD.
Adriamycin-induced Senescence in Breast Tumor Cells Involves Functional p53 and Telomere Dysfunction*

Direct experimental evidence implicates telomere erosion as a primary cause of cellular senescence. Using a well characterized model system for breast cancer, we define here the molecular and cellular consequences of adriamycin treatment in breast tumor cells. Cells acutely exposed to adriamycin exhibited an increase in p53 activity, a decline in telomerase activity, and a dramatic increase in β-galactosidase, a marker of senescence. Inactivation of wild-type p53 resulted in a transition of the cellular response to adriamycin treatment from replicative senescence to delayed apoptosis, demonstrating that p53 plays an integral role in the fate of breast tumor cells treated with DNA-damaging agents. Stable introduction of hTERT, the catalytic protein component of telomerase, into MCF-7 cells caused an increase in telomerase activity and telomere length. Treatment of MCF-7-hTERT cells with adriamycin produced an identical senescence response as controls without signs of telomere shortening, indicating that the senescence after treatment is telomere length-independent. However, we found that exposure to adriamycin resulted in an overrepresentation of cytogenetic changes involving telomeres, showing an altered telomere state induced by adriamycin is probably a causal factor leading to the senescence phenotype. To our knowledge, these data are the first to demonstrate that the mechanism of adriamycin-induced senescence is dependent on both functional p53 and telomere dysfunction rather than overall shortening.
Visual screening of Swedish children: an ophthalmological evaluation.

PURPOSE This study describes the various ophthalmological conditions detected in the Swedish visual screening program for children. METHODS The study was longitudinal and retrospective. All children (3126) born in 1982 in three Swedish municipalities have been followed from birth to ten years of age. Visual acuity was examined at the ages of 4, 5.5, 7 and 10 years. Before the age of 4, a gross examination of the eyes was performed. RESULTS The prevalence of ametropia in the population was 7.7%, the prevalence of strabismus 3.1%, and the prevalence of organic lesions 0.6%. Seven children (0.2%) were visually handicapped (visual acuity </=0.3 in the better eye). Refractive errors and microtropias were mainly detected at the age of 4, when the first visual acuity test was performed, while manifest strabismus was in many cases detected before this age. With this screening and subsequent diagnosis and treatment, the prevalence of deep amblyopia (visual acuity </=0.3) has been reduced from 2% to 0.2%. With treatment, 47% of the amblyopic children achieved a visual acuity better than 0.7. CONCLUSION Visual screening is effective in detecting visual and ocular disorders. Most conditions are discovered before the age of 6. Compared to an unscreened population, the prevalence of amblyopia is greatly reduced.
Doing Envy Justice: Examining the Politics of Envy

OF DISSERTATION DOING ENVY JUSTICE: EXAMINING THE POLITICS OF ENVY Conservatives and liberals disagree about the underlying motivations driving opposition to concentrated wealth. Liberals contend that such objections are often driven by legitimate fairness concerns, whereas conservatives frequently cite envy instead. Research and theory suggest that two particularly important contextual questions with respect to emotional reactions to wealth are its source (inherited or earned), and how that wealth is put to use, which could interactively and differentially influence liberals’ and conservatives’ reactions to affluent individuals. The current study aimed to empirically address whether liberals actually are more prone to envy than conservatives, both in general and in response to specific wealthy people of different backgrounds. Participants (N = 800) reported their reactions to ostensibly-real, wealthy entrepreneurs described in articles from a business news website. Liberals tended to respond with slightly more envy than conservatives across conditions, and controlling for several potential confounding factors, liberal political ideology was weakly positively correlated with dispositional envy. People across the political spectrum responded with greater envy in response to wealthy entrepreneurs who harmed others in the pursuit of wealth than entrepreneurs who did not harm others. However, liberals’ envy was increased more strongly by entrepreneurial harm-doing than conservatives’, and this difference was explained by greater perceived harm and unfairness. On the other hand, only conservatives reacted with greater envy to entrepreneurs who inherited their wealth rather than having earned it through hard work. Especially because, in addition to envy, liberals felt somewhat more resentment, moral disgust, and anger toward the wealthy entrepreneurs, further research will be necessary to fully understand the role of political ideology in reactions to affluent people.
The utility of EUS and EUS-guided fine needle aspiration in detecting celiac lymph node metastasis in patients with esophageal cancer: a single-center experience.

BACKGROUND The aims of this study were to determine the utility of EUS and EUS-guided fine needle aspiration (EUS-FNA) in the detection and confirmation of celiac lymph node metastasis in patients with esophageal cancer and to define EUS features predictive of celiac lymph node metastasis in these patients. METHODS The records of 211 patients with esophageal cancer who underwent EUS staging were reviewed. The operating characteristics of EUS were determined in patients where either surgery, EUS-FNA of a celiac lymph node, or both were performed (n = 102). The association between selected variables and the presence of celiac lymph node metastasis was evaluated by univariate and multivariable analyses. RESULTS EUS in 48 patients provided a true-positive diagnosis of celiac lymph node involvement, a false-positive and false-negative result, respectively, in 6 and 14 patients, and a true-negative diagnosis in 34 patients. The sensitivity of EUS in detecting celiac lymph node was 77% (95% CI [67, 88]), specificity 85% (95% CI [74, 96]), negative predictive value 71% (95% CI [58, 84]), and the positive predictive value 89% (95% CI [81, 97]). EUS-FNA was performed in 94% (51/54) of patients with celiac lymph nodes. The accuracy of EUS-FNA in detecting malignant celiac lymph nodes was 98% (95% CI [90, 100]). Advanced T-stage, the need for dilation, detection of peritumoral lymph nodes, and black race were associated with celiac lymph node involvement. In multivariable analysis, advanced T-stage was the strongest predictor of celiac lymph node involvement. CONCLUSION EUS and EUS-FNA are highly accurate in detecting and confirming celiac lymph nodes metastasis. Depth of tumor invasion as assessed by EUS is a strong predictor of celiac lymph node metastasis in patients with esophageal cancer.
Two-Stage Power Allocation for Dual-Hop Relaying Systems With Non-Orthogonal Multiple Access

To improve the sum-rate (SR) and the outage probability of the dual-hop relay system, a novel two-stage power allocation scheme with non-orthogonal multiple access is proposed. In this scheme, after the reception of the superposition coded symbol with a power allocation from the source, the relay decodes-and-forwards a new superposition coded symbol with another power allocation to the destination. By employing a simple linear combination, the destination jointly decodes the information symbols from the received signals from the source and the relay. Assuming Rayleigh fading channels, the ergodic SR and the outage performance of the system are investigated. In addition, a suboptimal power allocation strategy with closed form of the power allocation factors is also designed, which is close to the optimal one. Through numerical results, it is shown that the performance of the proposed scheme is significantly improved compared with the existing works.
Different seroprevalence and molecular epidemiology patterns of hepatitis C virus infection in Italy

The epidemiological picture of hepatitis C virus (HCV) infection in the general population is largely unknown, even in developed countries. The aim of this study was to estimate the prevalence and genotype distribution of HCV amongst a large sample of the Italian general population. A total of 3,577 serum samples were collected and screened for anti‐HCV antibodies. ELISA and RIBA tests were used to assess the presence of anti‐HCV. NS5b region sequencing was performed for molecular characterization. Of 3,577 tested sera, 95 (2.7%) were anti‐HCV positive and a genome was detected and sequenced in 50 sera. The age‐adjusted prevalence was 4.4%. Seroprevalence increased with age, following a North‐South gradient, and increased steeply between the 15 and 30 and 31–45 age groups. Subtype 1b showed the highest prevalence in all geographical areas and age groups, followed by subtypes 2c (detected mainly in the elderly population in Southern Italy), 4a/d, and 3a (detected exclusively in adults) and 1a. These findings confirm that Central and Southern Italy are hyperendemic areas. The high prevalence observed in adults over age 30 is mainly attributable to an increase in 1b‐prevalence but also to subtypes 2c‐ and 3/4‐infections. Age‐specific prevalence data and molecular characterization of the virus suggest that two transmission patterns co‐exist in Italy: one characterized by subtype 1b and 2c infections, mainly in adults older than 60 years, and the other by subtype 3 and 4 infections, mainly in the 31–60 year age group, and consistent with intravenous drug use and immigration. J. Med. Virol. 76:327–332, 2005. © 2005 Wiley‐Liss, Inc.
Fuel selection during prolonged arm and leg exercise with 13C-glucose ingestion.

PURPOSE To compare fuel selection during prolonged arm (AE) and leg exercise (LE) with water or glucose ingestion. METHODS Ten subjects (VO2max: 4.77 +/- 0.20 and 3.36 +/- 0.15 L x min(-1) for LE and AE, respectively) completed 120 min of LE and AE at 50% of the mode-specific maximal power output (353 +/- 18 and 160 +/- 9 W, respectively) with ingestion of water (20 mL x kg(-1)) or 13C-glucose (2 g x kg(-1)). Substrate oxidation was measured using indirect respiratory calorimetry corrected for urea excretion and 13CO2 production at the mouth. RESULTS The contribution of protein oxidation to the energy yield (%En) was higher during AE than LE (approximately 8% vs approximately 4%) because of the lower energy expenditure and was not significantly modified with glucose ingestion. With water ingestion, the %En from CHO oxidation was not significantly different during LE and AE (64 +/- 2% and 66 +/- 2%, respectively). Glucose ingestion significantly increased the %En from total CHO oxidation during AE (78 +/- 3%) but not during LE (71 +/- 2%). Exogenous glucose oxidation was not significantly different in AE and LE (56 +/- 4 and 65 +/- 3 g, respectively), but the %En from exogenous glucose was higher during AE than LE (30 +/- 1% and 24 +/- 1%) because of the lower energy expenditure. When glucose was ingested, the %En from endogenous CHO oxidation was significantly reduced during both AE (66 +/- 2% to 48 +/- 3%) and LE (64 +/- 2% to 47 +/- 3%) and was not significantly different in the two modes of exercise. CONCLUSIONS The difference in fuel selection between AE and LE when water was ingested was modest with a slightly higher reliance on CHO oxidation during AE. The amount of exogenous glucose oxidized was lower but its %En was higher during AE because of the lower energy expenditure.
Towards effective traffic congestion prediction in Egypt

Traffic congestion in Egypt is an issue where the aspects of the problem seem different from those of western countries. The problem is exaggerated in cities away from the capital where lack of governmental interest in such areas adds another dimension to the problem. The main objective of this paper is to investigate whether it is useful to apply known traffic congestion prediction approaches on an Egyptian highway and to analyse their performance. In order to do so, the following was performed : 1) Create an Egyptian dataset for a short term highways. 2) Apply known traffic congestion techniques such as artificial neural networks and neuro-fuzzy approaches on that dataset and to test their performance. Empirical work showed that traffic congestion could be effectively predicted using the applied methods. It also showed that error obtained using these methods outperforms related work on other datasets. Additionally, tests for assuring the goodness of fit are performed.
A Gender based Economic Analysis of Yam Production among Resource Poor Farm Households in Kwara State, Nigeria

Abstract The study carries out a gender based economic analysis of yam production among resource poor farm households in Kwara State with implication for poverty reduction in the state. One hundred and eighty randomly selected representative farm households were used for the study. Descriptive statistics, budgetary analysis and multiple regression model were the analytical tools. The results of the descriptive statistics show that 85% of the heads of the farm households were male with 66% of the male heads having no western education against 59% for the female-headed households. Labour cost was the major cost of production accounting for 64% and 66% of the total cost of production for the male and female-headed households, respectively. Yam production enterprise was profitable in the study area with net farm income of N136,950 and N128,800 for male and female-headed households, respectively. The return on capital employed was 48% and 45% for male and female-headed households, respectively. This shows that for every naira invested in yam production enterprise in the study area, average returns of 48kobo and 45kobo were obtained for the male and female-headed households, respectively. Farm size, family labour and yam seeds were the significant variables explaining the variation in yam output in the study area. Farm size and labour were under-utilised while yam seeds were over-utilised. The study recommends increased farm size and labour use per hectare and reduction in yam seeds per hectare for efficient resource use and increased net farm income for better living standard for the farm households.
Balancing the spatial demands of the developing dentition with the mechanical demands of the catarrhine mandibular symphysis

The superior transverse torus of the catarrhine mandible has been shown to effectively reduce bending at the symphysis during unilateral postcanine biting. While the adult superior transverse torus contains trabecular bone, the juvenile one is almost entirely filled by developing permanent incisors until their eruption. This study uses finite elements analysis (FEA) to investigate whether the presence of developing incisors in the juvenile symphysis increases strains on the superior transverse torus. Two FE models of a juvenile Macaca fascicularis mandible were created: one included all the developing teeth; the second was modified to remove the incisor tooth crypts by filling them with trabecular bone. The models were loaded identically to simulate static physiological unilateral biting on dp4 and strain magnitudes, patterns and distributions of the two FE models were compared. The FEA results show a notable increase in strain magnitudes by up to 40% when the developing incisors are present. The results indicate that, in order to maintain the same symphyseal strain magnitudes during chewing, the presence of the incisors in the symphysis necessitates a larger superior transverse torus in the juvenile than would be required if the superior transverse torus did not house the developing incisors. These results highlight the adaptational balance of the symphyseal morphology throughout ontogeny between biomechanics and the spatial demands of the developing dentition. Based on the findings we therefore propose that the spatial requirements of the developing incisors during ontogeny can act as a constraint on the functional adaptation and subsequent adult morphology observed in the catarrhine mandibular symphysis.
Expression of lymphatic vascular endothelial hyaluronan receptor-1 (LYVE-1) in the human placenta.

BACKGROUND Lymphatic vascular endothelial hyaluronan receptor-1 (LYVE-1) is a selective marker for lymphatic endothelium and a homolog of CD44, the hyaluronan (HA) receptor. HA in the extracellular matrix plays roles in tissue remodeling, development, and homeostasis, and as an HA receptor, LYVE-1 mediated HA metabolism might regulate these events. Currently, little is known about the lymphatic character within the human placenta. This study therefore determined LYVE-1 and other lymphatic markers in human placentas. METHODS AND RESULTS Placentas and villous tissue were fixed and immunostained for human LYVE-1 and CD44 and examined by RT-PCR. LYVE-1 was expressed at both protein and mRNA levels in trophoblast cells (TC) and in villous core endothelium (VCE). Predominant protein expression for LYVE-1 was observed in syncytiotrophoblast cells (TCs) of preterm placentas. Neither mRNA or protein for CD44 was expressed. Other blood and lymphatic-lineage molecules (VEGF-A, -C, and -D, Flt-1, KDR, Flt-4, and Prox-1) were examined by RT-PCR. VEGF-A, VEGF-D, and Flt-1 mRNA were observed in TCs and VCEs, while mRNA for VEGF-C, KDR, and Flt-4 was mainly observed in VCEs. Prox-1 was found at the mRNA, but not protein level in TCs and VCEs. Our findings indicate (1) the importance of LYVE-1, but not CD44, in regulation of HA metabolism in the maternal-fetal interface and fetal circulation, and (2) possible dual blood and lymphatic phenotypic characteristics in fetal endothelium. These results provide new insights into HA metabolism and lymphatic-lineage molecule expression in the human placenta.
Intracellular calcium store filling by an L‐type calcium current in the basolateral amygdala at subthreshold membrane potentials

The long‐term changes that underlie learning and memory are activated by rises in intracellular Ca2+ that activate a number of signalling pathways and trigger changes in gene transcription. Ca2+ rises due to influx via L‐type voltage‐dependent Ca2+ channels (L‐VDCCs) and release from intracellular Ca2+ stores have been consistently implicated in the biochemical cascades that underlie the final changes in memory formation. Here, we show that pyramidal neurones in the basolateral amygdala express an L‐VDCC that is active at resting membrane potentials. Subthreshold depolarization of neurones either by current injection or summating synaptic potentials led to a sustained rise in cytosolic Ca2+ that was blocked by the dihydropyridine nicardipine. Activation of metabotropic receptors released Ca2+ from intracellular Ca2+ stores. At hyperpolarized potentials, metabotropic‐evoked store release ran down with repeated stimulation. Depolarization of cells to −50 mV, or maintaining them at the resting membrane potential, restored release from intracellular Ca2+ stores, an effect that was blocked by nicardipine. These results show that Ca2+ influx via a low‐voltage‐activated L‐type Ca2+ current refills inositol 1,4,5‐trisphosphate (IP3)‐sensitive intracellular Ca2+ stores, and maintains Ca2+ release and wave generation by metabotropic receptor activation.
Associations between unprocessed red and processed meat, poultry, seafood and egg intake and the risk of prostate cancer: A pooled analysis of 15 prospective cohort studies

Reports relating meat intake to prostate cancer risk are inconsistent. Associations between these dietary factors and prostate cancer were examined in a consortium of 15 cohort studies. During follow‐up, 52,683 incident prostate cancer cases, including 4,924 advanced cases, were identified among 842,149 men. Cox proportional hazard models were used to calculate study‐specific relative risks (RR) and then pooled using random effects models. Results do not support a substantial effect of total red, unprocessed red and processed meat for all prostate cancer outcomes, except for a modest positive association for tumors identified as advanced stage at diagnosis (advanced(r)). For seafood, no substantial effect was observed for prostate cancer regardless of stage or grade. Poultry intake was inversely associated with risk of advanced and fatal cancers (pooled multivariable RR [MVRR], 95% confidence interval, comparing ≥45 vs. <5 g/day: advanced 0.83, 0.70–0.99; trend test p value 0.29), fatal, 0.69, 0.59–0.82, trend test p value 0.16). Participants who ate ≥25 versus <5 g/day of eggs (1 egg ∼ 50 g) had a significant 14% increased risk of advanced and fatal cancers (advanced 1.14, 1.01–1.28, trend test p value 0.01; fatal 1.14, 1.00–1.30, trend test p value 0.01). When associations were analyzed separately by geographical region (North America vs. other continents), positive associations between unprocessed red meat and egg intake, and inverse associations between poultry intake and advanced, advanced(r) and fatal cancers were limited to North American studies. However, differences were only statistically significant for eggs. Observed differences in associations by geographical region warrant further investigation.