Miracle-dz/UniFAR-FTUs huggingface dataset:
Three essays on over-education and labor market

Esta tesis estudia la sobre-educacion en el mercado de trabajo en Espana y el Reino Unido. Utilizando la base de datos Labor Force Survey primero se investiga si la sobre-educacion tiene una influencia significativa sobre el tipo de contrato (indefinido/temporal) en Espana. Los resultados demuestran que los trabajadores jovenes sobre-educados en Espana tienen menor probabilidad de obtener un contrato indefinido que los jovenes con educacion adecuada al puesto de trabajo. En el siguiente capitulo, estudiamos la probabilidad de obtener formacion por los trabajadores sobre-educados en Espana. Los resultados demuestran que estos trabajadores tienen menor probabilidad de participar en formacion relacionada con el trabajo que sus companeros con nivel de educacion adecuado al puesto de trabajo. Ademas, los trabajadores sobre-educados obtendrian mayor formacion si tuvieran un trabajo adecuado a su educacion. Finalmente, investigamos si los metodos de busqueda de trabajo afectan distintamente la probabilidad de estar sobre-educado para los graduados de campos "soft" vs. "hard" en el Reino Unido. El analisis revela que los graduados en campos "hard" pierden comparativamente a los graduados en campos "soft" si usan cualquier metodo de busqueda que no sea contactos personales.
Liquid biopsy for KRAS, NRAS and BRAF mutation testing in advanced colorectal cancer patients: the Argentinean experience.

Objective: To analyze the frequency of KRAS, NRAS and BRAF hotspot mutations in circulating tumor DNA (ctDNA) from patients with metastatic colorectal cancer (mCRC). Methods: Observational, descriptive and retrospective study in mCRC patients with available ctDNA-based genotype of KRAS, NRAS and BRAF. Results: The frequencies of plasma mutations for KRAS, NRAS and BRAF were 34% (± 7), 4% (± 3) and 4% (± 3), respectively. Median overall survival of plasma-tested RAS/BRAF-mutated patients was 26.6 months (95% CI: 14.4-not estimable [NE]), while RAS/BRAF wild-type patients did not reach the median survival during follow-up. Median progression-free survival for RAS/BRAF wild-type and RAS/BRAF-mutated patients was 12 (95% CI: 7-NE) and 4 months (95% CI: 4-NE), respectively. Conclusion: Our work supports the utility of KRAS, NRAS and BRAF analysis in liquid biopsy from mCRC patients.
Common mistakes in data presentation and statistical analysis: how can the BioStat Decision Tool help?

Common mistakes in data presentation and statistical analysis: 1 how can the BioStat Decision Tool help? 2 3 Anne L. Bishop and Siouxsie Wiles 4 5 Independent scholar, Nottingham, United Kingdom; Department of Molecular Medicine and 6 Pathology, University of Auckland, Auckland, New Zealand; Maurice Wilkins Centre for 7 Molecular Biodiscovery, New Zealand. 8 9 * Corresponding author: 10 Dr. Siouxsie Wiles 11 Department of Molecular Medicine and Pathology, University of Auckland 12 85 Park Road, Grafton, Building 502, Level 3 13 Auckland 1023 14 New Zealand 15 Phone: +64 9 373 7599 ext 84284 (office) 16 E-mail: s.wiles@auckland.ac. nz 17 18
Knowledge sharing through social media : investigating trends and technologies in a global marketing and advertising research company : original research

Background : The purpose of this study was to investigate social media technology trends in Nielsen - a global information and measurement company - and to establish how these technologies can help the company to create a knowledge-sharing culture. Objective : The objective of this study was to investigate trends in knowledge-sharing technologies in Nielsen. Method : The researchers distributed semi-structured questionnaires to a sample of employees in Nielsen's Television Audience Measurement Department. They also conducted interviews with specific employees in this department to gain a better understanding of employees' attitudes toward, and perceptions of, the use of social media tools for creating a knowledge-sharing culture at Nielsen. The researchers validated the data to see whether it could support the research and used triangulation to create a holistic view of the data they received from the questionnaires. Results : The findings of the study revealed that respondents had a positive attitude to sharing knowledge with one another through using social media tools. However, some respondents thought that technology, in general, was 'the tree of good and evil'. The survey findings showed that Nielsen did have social media tools. However, not all employees were aware of these tools or were willing to use the tools to share knowledge. This study highlighted the possible advantages of the social media for sharing knowledge and how Nielsen could use the tools more widely. Conclusion : In order for a knowledge sharing culture to thrive at Nielsen, its employees need to engage more with social media tools in their business practices.
Panorama epidemiológico y situacional de la hepatitis C en México

OBJECTIVE To determine the epidemiological situation of Chronic Hepatitis C (CHC) in our country. BACKGROUND DATA Chronic Hepatitis C affects 170 million people worldwide, and about 0.7% of Mexican population. There is no enough epidemiological information about CHC in our country, and it is very probable that some cases are not even detected. METHODS An investigation poll was performed. Age, gender, birthday, weight, race, residence and birth place, routes of transmission, ALT levels, histological, serological and molecular diagnosis, evidence of complications and previous treatments were recorded. A data recollection sheet was dispatched to different country provinces; they had 6 months to answer it, in order to recollect all information. RESULTS 831 patients were analized (58.6% female and 41.4% male) with the following distribution in our country provinces: Aguascalientes 15, Chihuahua 12, Distrito Federal 495, Durango 10, Jalisco 89, Guanajuato 78, Yucatan 8, Queretaro 11, Sonora 40, Tabasco 15, Baja California 5, Veracruz 13, Tamaulipas 2 and 38 patients of Nuevo Leon. The highest incidence of CHC was found at fifth and sixth decade of life (28.5% y 26.7% respectively. The weight distribution was 36.2% 75 kg. 86.5% had chronic hepatitis and 13.2% cirrhosis. The risk factors for HCV infection analysis showed that the main route of transmission was via contaminated blood (64.2%); when we excluded the patients that were exposed before 1995, the incidence was lowered to 4.5%. The higher incidence was showed between 1970 and 1990 (68%). The intravenous drug users were predominantly male and on those patients in the provinces near the north border line of our country. The predominant genotype was gen- 1 no matter the province (72.2%), in the intravenous drug users genotype 3 was found in 25%. The viral load was similar in all the provinces. 75% of the patients had have treatment and 22.5% had have two cycles, 50% of cirrhotic patients had have treatment whereas only 28% of the patients with late complications had have it. The most common treatment was pegylated alpha-2a interferon plus ribavirine. CONCLUSIONS 1. The main route of transmission was blood transfusion. There is a marked decrease in the incidence of post-transfusional hepatitis since the introduction of anti-VHC antibody screening of blood donors (4.5%). 2. The time between the infection and diagnosis was 23 years for chronic hepatitis and 26 years for cirrhosis. 3. Intravenous drugs use was an important route of transmission in the north of our country. 4. The predominant genotype was gen-1. 5. Almost all the patients with chronic hepatitis received treatment, the most common used was pegylated interferon alpha-2a and ribavirin. 6.50% of the patients with CHC have late complications.
Adopter Community Formation Accelerated by Repeaters of Product Advertisement Campaigns

This paper analyzes the dynamic nature of online adopter networks, which is amplified by users’ behavior, on the basis of the data sets obtained from a series of new product advertising campaigns on Twitter conducted by the Coca-Cola Company in 2016. The collected data reveal the following two interesting results: 1) campaign repeaters retweet campaign tweets at a significantly higher rate than first-time campaign participants and 2) participants form densely connected community structures. An analytical model in which users’ adoption decisions is controlled by the state transitions of their neighbors is introduced to confirm the phenomenon 2). The model further leads us to the following causal relationship: user behavior 1) is responsible for the phenomenon 2). Our findings indicate not only the case where the social network evolves on the same time scale as the online diffusion phenomenon but also the possibility that human behavior has a profound impact on the creation of inhomogeneous connectivity distributions among online adopters.
Towards a New Generation of Multimedia Learning Research.

Empirical research regarding the impact of multimedia on learning can be traced back several decades before the largescale invasion of multimedia learning resources (like CDROM titles and Internet applications) into the educational field and originated from areas outside the educational community. Although the results are not decisive, two generations of multimedia research have contributed to establishing factors that influence effective multimedia design. We summarize the conclusions of the existing research, specifying key theoretical issues, research directions, and weaknesses associated with each generation. Emerging factors, which have begun constituting a third generation of multimedia design and learning research are discussed. Suggestions are made regarding future trends of multimedia design and learning research.
Knowledge and Attitude Regarding Toxoplasmosis among Jazan University Female Students

Background: In Saudi Arabia, the prevalence of toxoplasmosis is high. However, to date, few studies have evaluated the degree of knowledge on toxoplasmosis among females in Saudi Arabia. Objectives: The objective of this study was to assess the knowledge, attitude and preventive behavior regarding toxoplasmosis among female students at Jazan University, Jazan, southwest Saudi Arabia. Materials and Methods: This cross-sectional study was conducted on a random sample of 440 female students at Jazan University using a semi-structured, self-administered questionnaire. Data with numerical/qualitative variables were expressed as frequency and percentage. Chi-square test was used to analyze categorical variables. P < 0.05 was used to indicate statistical significance. Results: This study found that more than three-quarters (79.1%) of the students had insufficient knowledge about toxoplasmosis. Students from healthcare faculties had higher knowledge scores (28.5%) than students from arts and humanities (20.6%) and science (18.9%) faculties; however, the differences were not statistically significant (P = 0.77). The majority of the studied sample (92.3%) was found to eat fast food on a regular basis. About 42%, 54% and 4% of the respondents reported that they never, occasionally and always ate improperly washed vegetables, respectively. Conclusions: This study found that a substantial proportion of Jazan University's female students have insufficient knowledge on toxoplasmosis. Health educational programs are necessary to increase the awareness and knowledge about toxoplasmosis and its clinical manifestations.
Suppression of human IL-1β, IL-2, IFN-γ, and TNF-α production by cigarette smoke extracts

Abstract Background: Although cigarette smoking is known to have detrimental effects on the immune system, the nature of the immunosuppressive agent or agents is poorly understood. Objective: The purpose of the current study was to evaluate the effects of cigarette smoke extracts from high-tar (unfiltered Camel), medium-tar (Marlboro), and low-tar (Carlton) cigarettes on the in vitro production of IL-1β, IL-2, IFN-γ, and TNF-α. Methods: The concentrations of hydroquinone and catechol in cigarette smoke extracts were determined by using HPLC. Human PBMCs were treated with cigarette smoke extracts, hydroquinone, or catechol, and stimulated with anti-CD3 and phorbol-12-myristate-13-acetate. Cytokine levels in the supernatants were quantified by ELISA. Results: Pretreatment of PBMCs with cigarette smoke extracts derived from a single high- or low-tar cigarette suppressed the production of IL-1β, IL-2, IFN-γ, and TNF-α by greater than 90% without significant loss of cell viability. Nicotine, at a concentration comparable with that found in the highest-tar cigarettes (200 μg/mL), suppressed the production of IL-2, IFN-γ, and TNF-α by only 21% to 38%. Catechol (50 μmol/L) inhibited production of IL-2 and IL-1β by 62% to 73% but had little effect on TNF-α or IFN-γ production. In contrast, hydroquinone inhibited the production of all 4 cytokines with IC 50 values ranging from 3 μmol/L(IL-1β) to 29 μmol/L (IFN-γ). However, HPLC determination of the hydroquinone concentrations in cigarette smoke extracts from single Camel (33 ± 4 μmol/L), Marlboro (13 ± 2 μmol/L), and Carlton ( Conclusion: These studies indicate that cigarette smoke contains potent inhibitors of cytokine production, at least one of which is present even in low-tar cigarettes. (J Allergy Clin Immunol 2000;106:280-7.)
Turoctocog alfa and drug development for hemophilia A

Introduction: Prophylactic replacement therapy with factor VIII (FVIII) is recommended as the foundation of treatment for severe hemophilia A; however, access to such therapy remains limited in many parts of the world. Introducing new products into the market may increase treatment accessibility across the global hemophilia community. Turoctocog alfa, a new and recently developed B-domain–truncated recombinant FVIII concentrate, further expands the therapeutic armamentarium for the prevention and treatment of bleeding episodes in hemophilia A. The lessons learned and insights gained throughout the nonclinical and clinical development of turoctocog alfa may offer guidance for future research in hemophilia A. Areas covered: This review summarizes the development of turoctocog alfa from production methods through to Phase III clinical development and the outcomes achieved in the pivotal guardian™ trial program. Key references relating to each step of the development process have been considered. Expert opinion: The turoctocog alfa clinical development program has led not only to the availability of a new, effective FVIII product for the treatment of hemophilia A but it has also demonstrated that large multinational trials can be successfully and quickly completed in this rare patient population.
Diet Pattern According to Socio-Economic status - Using the Fifth (2010-2012) Korea National Health and Nutrition Examination Survey

The purpose of our study is to analyze the effect of socio-economic status on the diet pattern of Korean adults. Raw data from the fifth (2010-2012) Korea National Health and Nutrition Examination Survey (KNHANES) were used, and finally 11,700 adults were analyzed as subjects. Results in consideration of the socio-economic status of the subjects, a linear trend was observed in men in which the odds ratio of having lunch (p for trend=0.006) and dinner (p for trend=0.0317) decreased as the level of education went down. In diet frequency, a decreasing trend (p for trend=0.0328) was observed in which the odds ratio of having 3 meals a day reduced as the household income lowered. For women, a linear trend (p for trend=0.0012) was observed in which the frequency of dinner decreased as the level of education became lower. A falling trend in the rate of having 3 meals a day was also observed (p for trend=0.0135). Our study analyzed the characteristics of the diet patterns of individuals according to their socio-economic status with the purpose of suggesting guidelines for correcting. To prevent this, we will need education and awareness and public attention for the practice of correct eating habits.
Software process modeling: a case study

Experiences in applying a specific modeling approach and technology to a portion of a software support process used by the US Air Force are related. The modeling approach is discussed in the context of examples drawn from the model developed. A view of the primary objectives of software process modeling, which formed the basis of the approach used, is set forth. The usefulness of the model is evaluated, and general lessons are drawn from the modeling effort. <<ETX>>
La viscérosensibilité chimique intestinale: Mécanismes et implications dans le contrôle de la prise alimentaire chez le rat

INTRODUCTION: Although, the implication of intestinal chemosensitivity in the control of food intake is now widely accepted, its precise mechanisms and its modalities of communication with the central nervous system remain poorly understood. OBJECTIVE: the aim of this study was to refine our understanding of nutrient detection within the intestine and to determine the involvement of vagal pathways in the transfer of visceral information from the gastrointestinal tract to the brain. RESULTS: the present study supports the hypothesis proposing that the intestine can be considered also as a sensory organ. It also appeared that the vagus nerve does play a role in transmitting visceral information to the brain. CONCLUSIONS: Vagally mediated intestinal chemosensitivity should be regarded as a sensory system having a strong influence on food intake control. Understanding its implications in energy homeostatic control will undoubtedly lead to develop new therapies to fight the present obesity epidemics.
Superposición del síndrome de intestino irritable y dispepsia funcional basados en criterios ROMA III en estudiantes de medicina de una universidad privada de Lima, Perú

Aims: To determine the prevalence of irritable bowel syndrome and functional dyspepsia in medical students from a private university in Lima, Peru. Furthermore, to determine the associated factors with these diseases. Material and methods: Observational descriptive and retrospective cross sectional study. Medical students from a private university in Lima were surveyed using a Rome III questionnaire for functional disorders and the STEPwise auto survey for defining the variables of alcohol and tobacco. For data analysis the Stata 11.0 program was used. Results: Of the 608 students, 543 answered the questionnaire. The prevalence of Irritable Bowel Syndrome was 12.4%, 16.9% of dyspepsia, and of both diseases simultaneously, a prevalence of 7.1% was found. Alcohol consumption in the total population was 89.4% and 29.0% of tobacco. Association between both disorders was found (OR 10.47, 95% CI 5.08 to 21.55; p <0.001), dyspepsia was associated with sex (OR: 0.16, 95% CI 0.07 to 0.36 p <0.001), with alcohol consumption (OR: 5.22, 95% CI 23.99 1,13- p = 0.034) and with irritable bowel syndrome (OR: 9.88, 95% CI 4.78 to 20.46 p <0.001). Both conditions together were associated with sex (OR: 0.20, 95% CI from 0.06 to 0.60 p = 0.004) and daily consumption of tobacco (OR: 3.23, 95% CI 1.17 to 8.89 p = 0.023). Conclusion: A prevalence of 12.4% of Irritable Bowel Syndrome and 16.9% of dyspepsia was determined. An overlap of 7.1% of these diseases was reported.
Object tracking using direct methods in RGB-D cameras

En esta tesis se presenta un analisis en profundidad de como se deben utilizar dos tipos de metodos directos, Lucas-Kanade e Inverse Compositional, en imagenes RGB-D y se analiza la capacidad y precision de los mismos en una serie de experimentos sinteticos. Estos simulan imagenes RGB, imagenes de profundidad (D) e imagenes RGB-D para comprobar como se comportan en cada una de las combinaciones. Ademas, se analizan estos metodos sin ninguna tecnica adicional que modifique el algoritmo original ni que lo apoye en su tarea de optimizacion tal y como sucede en la mayoria de los articulos encontrados en la literatura. Esto se hace con el fin de poder entender cuando y por que los metodos convergen o divergen para que asi en el futuro cualquier interesado pueda aplicar los conocimientos adquiridos en esta tesis de forma practica. Esta tesis deberia ayudar al futuro interesado a decidir que algoritmo conviene mas en una determinada situacion y deberia tambien ayudarle a entender que problemas le pueden dar estos algoritmos para poder poner el remedio mas apropiado. Las tecnicas adicionales que sirven de remedio para estos problemas quedan fuera de los contenidos que abarca esta tesis, sin embargo, si se hace una revision sobre ellas. ---ABSTRACT---This thesis presents an in-depth analysis about how direct methods such as Lucas- Kanade and Inverse Compositional can be applied in RGB-D images. The capability and accuracy of these methods is also analyzed employing a series of synthetic experiments. These simulate the efects produced by RGB images, depth images and RGB-D images so that diferent combinations can be evaluated. Moreover, these methods are analyzed without using any additional technique that modifies the original algorithm or that aids the algorithm in its search for a global optima unlike most of the articles found in the literature. Our goal is to understand when and why do these methods converge or diverge so that in the future, the knowledge extracted from the results presented here can efectively help a potential implementer. After reading this thesis, the implementer should be able to decide which algorithm fits best for a particular task and should also know which are the problems that have to be addressed in each algorithm so that an appropriate correction is implemented using additional techniques. These additional techniques are outside the scope of this thesis, however, they are reviewed from the literature.
Space syntax based agent simulation

Space syntax derives from a set of analytic measures of configuration that have been shown to correlate well with how people move through and use buildings and urban environments. Space syntax represents the open space of an environment in terms of the intervisibility of points in space. The measures are thus purely configurational, and take no account of attractors, nor do they make any assumptions about origins and destinations or path planning. Space syntax has found that, despite many proposed higher-level cognitive models, there appears to be a fundamental process that informs human and social usage of an environment. In this paper we describe an exosomatic visual architecture, based on space syntax visibility graphs, giving many agents simultaneous access to the same pre-processed information about the configuration of a space layout. Results of experiments in a simulated retail environment show that a surprisingly simple ‘random next step’ based rule outperforms a more complex ‘destination based’ rule in reproducing observed human movement behaviour. We conclude that the effects of spatial configuration on movement patterns that space syntax studies have found are consistent with a model of individual decision behaviour based on the spatial affordances offered by the morphology of the local visual field.
Social networks and the "Training Gospel"

This article questions the widely assumed connection between qualifications and employment and suggests that poorly qualified school leavers rely on accessing social networks to find employment more than they rely on acquiring relevant qualifications. To test this hypothesis, the article draws on data generated in interviews conducted with 10 tutors working for Private Training Establishments and two senior managers employed by Skill New Zealand. The data presented suggest that to get students into employment, and thus supply the training outcomes purchased by Skill New Zealand, the tutors relied heavily on their network capital. In this respect, Skill New Zealand has emerged as a purchaser of social networks.