Miracle-dz/UniFAR-FTUs huggingface dataset:
Mapping the co-localization of the circadian proteins PER2 and BMAL1 with enkephalin and substance P throughout the rodent forebrain

Despite rhythmic expression of clock genes being found throughout the central nervous system, very little is known about their function outside of the suprachiasmatic nucleus. Determining the pattern of clock gene expression across neuronal subpopulations is a key step in understanding their regulation and how they may influence the functions of various brain structures. Using immunofluorescence and confocal microscopy, we quantified the co-expression of the clock proteins BMAL1 and PER2 with two neuropeptides, Substance P (SubP) and Enkephalin (Enk), expressed in distinct neuronal populations throughout the forebrain. Regions examined included the limbic forebrain (dorsal striatum, nucleus accumbens, amygdala, stria terminalis), thalamus medial habenula of the thalamus, paraventricular nucleus and arcuate nucleus of the hypothalamus and the olfactory bulb. In most regions examined, BMAL1 was homogeneously expressed in nearly all neurons (~90%), and PER2 was expressed in a slightly lower proportion of cells. There was no specific correlation to SubP- or Enk- expressing subpopulations. The olfactory bulb was unique in that PER2 and BMAL1 were expressed in a much smaller percentage of cells, and Enk was rarely found in the same cells that expressed the clock proteins (SubP was undetectable). These results indicate that clock genes are not unique to specific cell types, and further studies will be required to determine the factors that contribute to the regulation of clock gene expression throughout the brain.
Preparation of fish waste silage and its effect on the growth performance and meat quality of broiler chickens.

BACKGROUND This experiment was conducted to evaluate the effects of replacing soybean meal with fish-waste silage (FWS) in diets on growth performance and meat quality in broiler chickens. Fish waste (FW) was fermented with molasses and Lactobacillus plantarum and Aspergillus oryzae for 15 days. A total of 240 day-old male Cobb 500 broiler chickens were used in a 42-day experiment in which the birds were randomly allotted to one of five dietary treatments (containing 0, 30, 60, 90, and 120 g kg-1 FWS) in a completely randomized design. RESULTS Results indicated that the fermentation process significantly reduced pH and ether extract, but it increased crude protein content and lactic acid bacteria count in FW. The use of FWS significantly improved daily weight gain and feed conversion ratio of broilers. The amount of thiobarbiturate-reducing substances and lipid content in chicken's meat fed diet containing FWS was significantly lower than in the group fed a control diet. CONCLUSION In conclusion, the microbial fermentation process is effective in improving nutritive values of FW. Feeding up to 120 g kg-1 FWS also improves the performance and meat quality of birds and can be used as a suitable protein source in broiler chickens' diet. © 2018 Society of Chemical Industry.
Low serum levels of sex steroids are associated with disease characteristics in primary Sjogren's syndrome; supplementation with dehydroepiandrosterone restores the concentrations.

CONTEXT Serum levels of the sex steroid prohormones dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEA-S) decline upon aging and are reduced in primary Sjogren's syndrome. OBJECTIVE Our aim was to investigate: 1) effects of 50 mg oral DHEA/day on changes in serum levels of DHEA and 12 of its metabolites; 2) relationships between steroid levels and disease characteristics; and 3) whether these parameters were influenced by DHEA. DESIGN Twenty-three postmenopausal women with primary Sjogren's syndrome and subnormal levels of DHEA-S were included in a randomized, 9-month, controlled, double blind crossover study. Liquid chromatography/mass spectrometry (MS)/MS and gas chromatography/MS were used to measure the sex steroids. Anti-SS-A/Ro and/or anti-SS-B/La, salivary gland focus score, salivary flow rates, dry mouth and eye symptoms, and routine laboratory tests were assessed. RESULTS Baseline erythrocyte sedimentation rate was inversely correlated with testosterone (Testo), dihydrotestosterone, and DHEA-S (rs = -0.42, -0.45, and -0.58, respectively). Dry mouth symptoms correlated with low Testo and androstenedione, whereas dry eyes correlated with low estrogens, most strongly estrone (rs = -0.63). Presence of anti-SS-A and/or anti-SS-B was independently associated with low estradiol (area under the receiver operating characteristic curve, 0.82). All metabolites increased during DHEA but not during placebo. The relative increases were less for estrogens and Testo compared to dihydrotestosterone and glucuronidated androgen metabolites. Dry mouth symptoms decreased during DHEA therapy. CONCLUSIONS Disease manifestations in primary Sjogren's syndrome were associated with low sex hormone levels, dry mouth symptoms with low androgens, and dry eyes with low estrogens. Exogenous DHEA was preferentially transformed into androgens rather than into estrogens.
Spatial and temporal variability in VOC levels within a commercial retail building.

UNLABELLED A study was performed to characterize the concentration of dozens of volatile organic compounds (VOCs) at 10 locations within a single large building and track these concentrations over a 2-year period. The study was performed at a shopping center (strip mall) in New Jersey. A total of 130 indoor air samples were collected from 10 retail stores within the shopping center and analyzed for 60 VOCs by US EPA Method TO-15. Indoor concentrations of up to 55,100 microg/m(3) were measured for individual VOCs. The indoor/outdoor ratio (I/O) was as high as 1500 for acetone and exceeded 100 at times for various compounds, indicating that significant indoor air sources were present. A large degree of spatial variability was observed between stores within the building, with concentrations varying by three to four orders of magnitude for some compounds. The spatial variability was dependent on the proximity of the sampling locations to the indoor sources. A large degree of temporal variability also was observed for compounds emitted from indoor sources, but the temporal variability generally did not exceed two standard deviations (sigma). For compounds not emitted from indoor sources at significant rates, both the spatial and temporal variability tended to range within an order of magnitude at each location. PRACTICAL IMPLICATIONS Many cross-sectional studies have been published where the levels of volatile organic compounds (VOCs) were measured in indoor air at one or two locations for houses or offices. This study provides longitudinal data for a commercial retail building and also addresses spatial variability within the building. The data suggest that spatial and temporal variability are important considerations for compounds emitted from indoor sources. Elevated concentrations were found in retail spaces with no apparent emission sources due to their proximity to other retail spaces with emission sources.
Value relevant asset measurement and asset use: Evidence from IAS 41

I examine whether asset measurement linked to asset use provides investors with incrementally more value relevant information in a sample of 183 international firms from 35 countries that adopt International Accounting Standard (IAS) 41. IAS 41 prescribes fair value measurement for biological assets, a class of assets previously classified as PPE May 1936), current asset measurement frameworks, and the International Accounting Standards Board's (2013) recent revisions to the asset measurement section of its conceptual framework.
Implications of Organizational Culture and Leadership Styles The Effects on Job Satisfaction and Organizational Performance Of Police Sector In Bandung, Cimahi, Garut- West Java.

Police Sectors in Bandung, Cimahi and Garut are considered that they are not able to give the best performance yet, where the crime tends to upset the society. Furthermore, the perpetrators of several criminal cases cannot be revealed yet. The aims of this study are to measure and analyze the extent to which the police organizations performance are influenced by organizational culture, leadership style and job satisfaction. This study used a quantitative approach with path analysis as its method where 167 policemen were used as its samples. The research findings show that organizational culture significantly affected towards the job satisfaction, but insignificantly affected the organizational performance. Leadership style significantly affected job satisfaction, but insignificantly affected the organizational performance. Job satisfaction worked as a mediator of the effect between the relationship of organizational culture and organizational performance, and between the relationship of leadership style and organizational performance.
6th International Conference on Information and Communication Technologies in Agriculture, Food and Environment (HAICTA 2013) Predicting Consumer's Perceptions in On-line Shopping

The diffusion of the e-commerce is now well-known in all of its types of activities. The four types that described in this paper is the most common and shows how people nowadays that is familiar with the Internet, tend to adopt more easily than the previous years. The results will indicate which are the major concerns for people in order to adopt one of those activities. Also, even now that internet has been so widely spread and used, people are so pessimistic in e-commerce adoption because of the risk or not. Of course the research is by its nature web-based so the appropriate data collection is via e-mail. The findings of the survey might be useful for companies and businesses which are active in this field. © 2013 The Authors. Published by Elsevier B.V. Selection and peer-review under responsibility of HAICTA.
The Older or Ageing Consumers in the UK

This article explores the characteristics and attractiveness of UK older consumers to marketers. It shows that the UK's ageing population is potentially a dominant segment of the consumer market of the future. However, it is hard to identify this group of consumers. The research demonstrates that UK companies do not have specific programmes to attract and keep older consumers. This is despite their acknowledging that older consumers are attractive. They regard older consumers merely as a segment of a wider consumer market. In this article, the various definitions of ageing are discussed and the prevailing methods of responding to the needs of older consumers are examined. While some of the current approaches in segmenting and targeting consumer markets are generally useful it was found that they are applied in a simplistic way for the purpose of segmenting and targeting older consumers. This article recognises that older consumers are heterogeneous and their characteristics have little association with their chronological ages. It is concluded that there are many unanswered questions; for example, what are the factors that influence older consumers to buy certain brands, to target particular sales people, or to patronise certain suppliers of products or providers of services? The article poses a practical question of how marketers, for the purpose of targeting their marketing efforts and positioning their products and services, may identify these older consumers. Given their chronological ages, could marketers predict their buying behaviour? The implications of the results of the study for both practice and theory are identified and further lines of research proposed.
A qualitative analysis of the perception of stigma among Latinos receiving antidepressants.

OBJECTIVE This study sought to describe the role of stigma in antidepressant adherence among Latinos. METHODS The study utilized data generated from six focus groups of Latino outpatients receiving antidepressants (N=30). By using a grounded theory approach, qualitative analysis focused specifically on the role of stigma in antidepressant treatment, as well as salient Latino values. RESULTS Perceptions of stigma were related to both the diagnosis of depression and use of antidepressant medication. Qualitative analyses showed that antidepressant use was seen as implying more severe illness, weakness or failure to cope with problems, and being under the effects of a drug. Reports of stigma were also related to social consequences. Also, the perceived negative attributes of antidepressant use were at odds with self-perceived cultural values. CONCLUSIONS Stigma was a prominent concern among Latinos receiving antidepressants, and stigma often affected adherence. Furthermore, culture is likely to play an important role in the communication of stigma and its associated complications.
Estimation of Mechanical Vibrations of the LHC Fast Magnetic Measurement System

Current installation of the large hadron collider (LHC) particle accelerator at CERN has required the use of a harmonic coil magnetic measurement system to quantify the magnetic field harmonic quality of the superconducting, twin aperture LHC dipoles. Current and future needs for measuring fast changing magnetic fields necessitates the use of a rotating unit (RU) and associated electronics to drive this long shaft with increased speed and measurement bandwidth. Therefore, the fast magnetic measurement equipment (FAME) project has been launched to deliver such a system. A primary obstacle to achieving the goals of the FAME project is the possibility of amplifying mechanical vibrations due to increased speeds. This paper presents the methodology and results of an experimental investigation conducted to estimate mechanical vibrations of the long shaft within a cold-bore mounted anti-cryostat at various rotational speeds using magnetic measurements.
ISO 9001 IMPLEMENTATION STUDIES ON SMALL MEDIUM ENTERPRISE: MOTIVES, PROBLEMS, AND BENEFITS

The ISO 9001 implementation trend has spread to small and medium enterprise (SME) sector. Given this, the research aims to examine the motives, problems, and the benefits gained by the SME after applying that quality management system standard. The research uses a case study descriptive approach. The research object is a rubber processing SME. Data were gathered through informal interviews and discussions with the research object‘s ISO 9001 consultant and a review of quality documents and records that are owned by the research object. The research result shows that the research object‘s motives in implementing ISO 9001 is an external drive (customer requirement). The problems faced are financial limitations, lack of resources, and lack of human resource skills. Meanwhile the significance benefits gained are the mapped business processes, documented working methods, and fulfilled customer requirement. As a comparison, the findings were compared with similar research on a SME in Canada. Kata kunci: ISO 9001, SME, motives, problems, benefits
Measuring Web Advertising Effectiveness in China

ABSTRACT This study examines Chinese consumers' perceptions and responses to web banner advertising. Results suggest that just one additional banner exposure improves Chinese users' brand recall, changes their attitude toward the brand, and increases their purchase consideration. Although clickthrough was found to be a significant predictor for banner recall, there was no evidence that clickthrough affects brand recall, attitude toward the brand, or purchase consideration.Most of the findings in this study are congruent with those reported in the 1997 IAB Study.
Influence of processing on the comparative feeding value of barley for feedlot cattle.

Ninety-six crossbred steers were used in a 172-d feedlot growth performance trial to determine the effects of type processing on the comparative feeding value of barley in a 90% concentrate finishing diet. Treatments were: 1) steam-flaked corn (SFC; density = .31 kg/L); 2) dry-rolled barley (DRB; density = .39 kg/L); 3) steam-rolled barley, coarse roll (SRB-C, density = .39 kg/L); and 4) SRB, thin roll (SRB-T, density = .19 kg/L). The ADG was similar (P > .10) across barley treatments, averaging 1.29 kg/d. Feed intake (P < .05) was lower for SRB than for DRB. Diet NE was greater (P < .05) for SRB than for DRB. Feed intake was lower (P < .05) for SFC than for barley diets. The influence of grain processing on characteristics of digestion was evaluated using four Holstein steers (average BW = 230 kg) with cannulas in the rumen and proximal duodenum. Ruminal and total tract digestibility of OM and starch were lower (P < .05) for DRB than for SRB. Ruminal and total tract digestibility of OM and starch were similar (P > .10) for SRB-C and SRB-T. However, passage of nonammonia N was markedly increased (26.9%, P < .01) with SRB-T compared with SRB-C. This increase in ruminal N efficiency was due partly to reduced ruminal degradation of feed N (23.4%, P < .01) and partly to increased microbial N synthesis (13.3%, P > .10). The comparative feeding value of DRB, SRB-C, and SRB-T in this study was 90, 92, and 96% the value of SFC, respectively. (ABSTRACT TRUNCATED AT 250 WORDS)
The Implementation of a Market Orientation: A Review and Integration of the Contributions to Date

Purpose - The purpose of this paper is to review the market orientation literature from a managerial perspective and to discuss and integrate the implementation lessons that can be drawn from it. Design/methodology/approach - The paper starts with a review of the managerial implications of the market orientation literature. It then provides an overview of nine implementation approaches. It draws on an integrative model of marketing orientation to organize the implementation lessons from the literature into an actionable approach to implementing a market orientation. Findings - The paper finds that the literature offers a rich, yet fragmented, picture of what market orientation is, and how it can be improved. Research limitations/implications - The paper identifies a conceptual gap in the literature between market orientation and customer value generation and offers a model to bridge this gap that can serve as a guide for future theory development and empirical research. Practical implications - The paper identifies four design enablers and three development enablers that can guide managerial action to improve market orientation and offers practitioners a structured way to go about the implementation of a market orientation. Originality/value - Despite significant advances in the development of market orientation theory, there is still a void in the literature with respect to the implementation of a market orientation. This paper is the first to review the market orientation literature from a managerial perspective, to provide an overview of the implementation approaches published to date, and to integrate the managerial implications of the market orientation literature.
High-frequency homogenization for periodic media

An asymptotic procedure based upon a two-scale approach is developed for wave propagation in a doubly periodic inhomogeneous medium with a characteristic length scale of microstructure far less than that of the macrostructure. In periodic media, there are frequencies for which standing waves, periodic with the period or double period of the cell, on the microscale emerge. These frequencies do not belong to the low-frequency range of validity covered by the classical homogenization theory, which motivates our use of the term ‘high-frequency homogenization’ when perturbing about these standing waves. The resulting long-wave equations are deduced only explicitly dependent upon the macroscale, with the microscale represented by integral quantities. These equations accurately reproduce the behaviour of the Bloch mode spectrum near the edges of the Brillouin zone, hence yielding an explicit way for homogenizing periodic media in the vicinity of ‘cell resonances’. The similarity of such model equations to high-frequency long wavelength asymptotics, for homogeneous acoustic and elastic waveguides, valid in the vicinities of thickness resonances is emphasized. Several illustrative examples are considered and show the efficacy of the developed techniques.
Strategic Motives of Turkish Foreign Direct Investment Firms: An Empirical Study on Manufacturing Sector

Abstract This paper aims to determine and assess strategic motives of Turkish manufacturing firms’ (TMFs) foreign direct investment (FDI) involvement by the use of a broad set of factual and perceptual measures. Relying on the past research we have developed a number of hypotheses relating to firm characteristics and motives. Based on the analysis of 94 parent firm managers’ responses to a survey, first, we find that market-related motives (such as market potential, market access) appear to be the most important motives. Second, the results show that the relative importance of TMFs’ strategic motives do not vary with parent firm age; but, to a limited degree, they vary depending on subsidiary firm age. Third, strategic motives, to some extend, differ based on the size of the sampled firms and the size of their foreign subsidiaries. Fourth, motives of TMFs do not vary based on their sub-sector and entry mode. Finally, the results suggest that favorable business environment seeking and strategic asset seeking motives are significantly associated with investment in developed countries (DCs); and, cultural asset exploiting and efficiency seeking motives are significantly associated with investment in less developed countries (LDCs).
A Generic Concept of Marketing

The proposal that marketing is relevant to all organizations having customer groups was advanced in the January, 1969 issue of this journal. It is now stated that the original broadening proposal should be broadened still further to include the transactions between an organization and all of its publics. The author sees marketing as the disciplined task of creating and offering values to others for the purpose of achieving a desired response. The generic view of marketing is defined by a set of four axioms and leads to new marketing typologies and views of the tasks of marketing management.
Estradiol, Esteriol, Estrone and Novel Flavonoids from Date Palm Pollen

Column chromatography of the Egyptian date palm pollen, resulted in the isolation of estradiol, estrone among ten compounds from the hexane fraction. Also, besides rutin, additional four flavonoids from the ethyl acetate extract were isolated. HPLC analysis of the hexane fraction (using RF- BDS C18 - isocratic acetonitrile /water 58:42) revealed the presence of estrone, estradiol and estriol compared with R t of reference standards. The Antioxidant activity by the DPPH method indicated that the ethyl acetate fraction possess a relatively strong antioxidant against DPPH radicals with value (SC50 $ 16.51 µg / ml ). Pollen grains of date palm (Phoenix dactylifera L., 0.5 Kg ) were extracted 3 ×2 L Me OH (each for 2 days) at room temperature. The combined extracts were evaporated to dryness in vacuum to afford 50 g residue. This residue was suspended in 300 ml H2O and then extracted successively with n- hexane, pet ether, CHCl 3 , ether, and EtOAc to yield 5 corresponding fractions (33.7, 0.9, 0.7,, 0.4 and 3 g, respectively).