Miracle-dz/UniFAR-FTUs huggingface dataset:
“Big 4 fee premium” and audit quality: latest evidence from UK listed companies

Purpose - Using the most recent observations (2005-2011) from a sample of UK listed companies, This paper aims to investigate whether Big 4 audit firms exhibit a “fee premium” and, if this is the case, whether the premium is related to the delivery of a better audit service. Design/methodology/approach - Univariate tests, multivariate regressions and two methodologies that control for self-selection bias are used to answer the proposed research questions. Data are collected from DataStream. Findings - Findings provide consistent evidence about the existence of an “audit fee premium” charged by Big 4 firms while they do not highlight any significant relationship between audit quality and type of auditor with respect to the audit quality proxies investigated. Research limitations/implications - Evidence from this paper might signal the need for legislative intervention to improve the competitiveness of the audit market on the basis that its concentrated structure is leading to “excessive” fees for Big 4 clients. Findings might also enhance Big 4 client bargaining power. However, as the paper analyses only one country, generalizability of the results might be a limitation. Originality/value - This study joins two streams of the extant literature that investigate the existence of a “Big 4 audit fee premium” and different levels of audit quality among Big 4 and non-Big 4 clients. Evidence supports the concerns raised by the UK House of Lords in 2010 that the concentrated structure of the audit market could be the driver of “excessive” fees for Big 4 clients as it does not find differences in audit quality between Big 4 and non-Big 4 clients.
The relationship between practice setting and management of preterm premature rupture of membranes

Objective. To compare preterm premature rupture of membranes (PPROM) management between maternal-fetal medicine (MFM) providers practicing in an academic university (AU) versus other settings (NAU). Methods. Secondary analysis of a national survey of 1375 MFM providers of whom 504 (37%) responded and answered queries on demographic and practice characteristics and various PPROM management issues. Results. Fifty-three percent of the respondents were in an AU practice setting. Providers in AU and NAU settings reported a similar prevalence of corticosteroid (99% vs. 100%), antibiotic (99% vs. 100%), and tocolytic (74% vs. 76%) use. There was significant variability between NAU and AU providers in issues related to the evaluation and expectant management of PPROM. NAU providers, as compared to AU providers, more commonly reported performing diagnostic amniocentesis in the acute evaluation of PPROM (72% vs. 61%, p = 0.02). There was a higher prevalence of fetal lung maturity assessment among NAU providers (84%) as compared to AU providers (73%, p = 0.005) and significant variability was noted with respect to the fetal lung maturity tests used (p < 0.0001). NAU providers continued expectant management later into gestation than AU providers (p = 0.002). Significant variability was also noted in the use of antepartum surveillance techniques (p = 0.01). Conclusion. MFM practitioners from academic universities and non-academic settings utilize similar management strategies for PPROM in regard to corticosteroid, tocolytic, and antibiotic use. However, differences are evident in issues related to the evaluation and expectant management of patients with PPROM.
Green pretexts: Ecotourism, neoliberal conservation and land grabbing in Tayrona National Natural Park, Colombia

While conflict-related dynamics are recognized as causes of land grabbing in Colombia, violent processes of exclusion and expropriation behind ‘greener’ projects are often seen as disconnected from them. The case of ecotourism in Tayrona National Natural Park makes it possible to explore the geographies of violence that sustain tourism in the area and their role in shaping everyday resource politics. This paper shows how green pretexts of paradisiacal spots in need of protection have contributed to privatization and dispossession. Furthermore, it details how land-grabbing dynamics have been enabled by processes of sociospatial demarcation that produce not-green-enough subjects as bodies-out-of-place.
Environmental Risks Associated with Booster Biocides Leaching from Spent Anti‐Fouling Paint Particles in Coastal Environments

Boat maintenance facilities in coastal areas contribute a significant amount of antifouling paint particles (APP) to coastal environments. Very few studies have concentrated on the leaching of booster biocides embedded in old paint particles. Therefore, this study attempted to assess the leaching of Dichlofluanid and Irgarol 1051 from APP collected from Mayflower Marina in southwest England. They were analyzed by GC‐MS. A leaching experiment revealed that a considerable amount of Dichlofluanid (ca. 24 μg/L) leached from 0.4 g/L of APP after the first hour, followed by a marked decline in the amount measured in the water over time, almost degrading after 24 h in seawater, affording less of an environmental threat to non‐target organisms. Conversely, Irgarol 1051 appeared to be persistent and continuously leached from the 0.4 g/L of APP even after 10 days, yielding a concentration of 0.61 μg/L in seawater, potentially posing a significant threat to the aquatic environment through leaching from APP.
The letrozole (L), exemestane (E), and anastrozole (A) pharmacodynamics (LEAP) trial: A direct comparison of bone biochemical measurements between aromatase inhibitors (AIs) in healthy postmenopausal women.

555 Background: The LEAP trial is an open, randomized, multicenter, Phase I pharmacodynamic study comparing the effects of the AIs L, E and A on safety parameters, such as serum markers of bone formation and resorption, lipid profiles, and adrenal function in healthy postmenopausal women with normal bone mineral density at the spine and hip. Elevated bone biochemical levels indicate high turnover of bone, and correlate with a loss in bone mineral density. It has been suggested that there are differences between the effect of the steroidal AIs (E) and non-steroidal AIs (A and L) on bone turnover, with steroidal AIs having a less negative effect. METHODS Healthy volunteersfrom the UK and Hungarywere randomized to receive A (1 mg/day), L (2.5 mg/day), or E (25 mg/day) orally, once daily for 24 weeks. Changes from baseline in log-transformed bone alkaline phosphatase (ALP), serum C-telopeptide crosslinks (CTX), parathyroid hormone (PTH) and propeptide of type I procollagen (PINP) at 24 weeks on A, were compared with those on L and E by ANCOVA, adjusting for treatment, baseline measurement, BMI, smoking status and baseline estradiol. No adjustments were made for multiple comparisons. RESULTS A total of 102 healthy volunteers were recruited, with 90 participants evaluable at 24 weeks (29 A, 29 L, 32 E). Participant demographics were similar between the treatment groups in terms of age, years since menopause, and history of hysterectomy and oophorectomy. Bone biochemical measurement changes are presented in the table . With the exception of PTH, where there is a greater decrease in PTH with E than with A (p=0.04), there were no statistically significant differences between the AIs. CONCLUSIONS The steroidal and non-steroidal AIs appear to have similar effects on bone biochemical measurements, and thus bone turnover. All three licensed AIs result in increases in bone turnover. [Table: see text] [Table: see text].
Regulation and innovation: rethinking ‘inclusive’ housing design

The Lifetime Homes (LTH) concept initiated in 1989 by the Helen Hamlyn Trust, and subsequently promoted by the Joseph Rowntree Foundation, emerged at a point when there was growing awareness of the decline of both private and public sector housing quality, especially in relation to floorspace standards (Karn & Sheridan, 1994). LTH were intended to offset the concerns of first, the house buying public of the appearance and affordability of homes suitable for successive generations, second, the private house building industry of the cost and marketability of incorporating ‘inclusive’ design features, and third, Registered Social Landlords (RSLs), who had to balance cost constraints with addressing the needs of a growing number of households with older and/or disabled people. Approved Document Part M of the building regulations was extended in 1999, from public buildings to private dwellings, and currently requires that all new housing meet minimal ‘visitability’ criteria. Indeed, although the signs are that Part M will be incrementally extended to comprise LTH principles, the paper argues that in their existing form they are insufficient to act as a key component of the government's ‘new agenda for British housing’. This paper therefore explores how they might usefully be expanded from an approach, largely based on compromise, to one that inspires innovative, flexible and inclusive house forms, which also challenge design conventions.
Involvement of fibroblast growth factor 18 in dedifferentiation of cultured human chondrocytes

Objective: Chondrocytes inevitably decrease production of cartilaginous matrices during long‐term cultures with repeated passaging; this is termed dedifferentiation. To learn more concerning prevention of dedifferentiation, we have focused here on the fibroblast growth factor (FGF) family that influences chondrocyte proliferation or differentiation.
Has the Digital Divide Been Reversed? Evidence from Five EU Countries

This paper examines whether there is a digital divide in the use of the internet in general and for specific purposes (leisure, improving human capital and obtaining goods and services). It uses a unique dataset which covers the entire clickstream of almost 20,000 internet users in the five largest EU economies during 2011. Our main finding is that, for those who have access to the Internet, the income-based digital divide in internet use has been reversed. Low-income internet users spend more time on the internet than high-income users. In addition, we find that employment status does not change the effect of income on internet use and we discuss several possible explanations for this result. There is some evidence of an education-based digital divide in the use of human capital and goods & services websites. Tertiary education has a negative effect on time spent on leisure websites and a positive effect on time spent on human capital and goods & services websites. Using quantile regressions, we find that the negative effect of income and the positive effect of education for human capital and goods & services websites hold for the entire conditional distribution of these online activities. Moreover, these effects are stronger for more intensive internet users.
Endoglycosidase treatment abrogates IgG arthritogenicity: Importance of IgG glycosylation in arthritis

The glycosylation status of IgG has been implicated in the pathology of rheumatoid arthritis. Earlier, we reported the identification of a novel secreted endo‐β‐N‐acetylglucosaminidase (EndoS), secreted by Streptococcus pyogenes that specifically hydrolyzes the β‐1,4‐di‐N‐acetylchitobiose core of the asparagine‐linked glycan of human IgG. Here, we analyzed the arthritogenicity of EndoS‐treated collagen type II (CII)‐specific mouse mAb in vivo. Endoglycosidase treatment of the antibodies inhibited the induction of arthritis in (BALB/c × B10.Q) F1 mice and induced a milder arthritis in B10.RIII mice as compared with the severe arthritis induced by non‐treated antibodies. Furthermore, EndoS treatment did not affect the binding of IgG to CII and their ability to activate complement, but it resulted in reduced IgG binding to FcγR and disturbed the formation of stable immune complexes. Hence, the asparagine‐linked glycan on IgG plays a crucial role in the development of arthritis.
Evidence Gap Maps - a Tool for Promoting Evidence-Informed Policy and Prioritizing Future Research

Evidence-gap maps present a new addition to the tools available to support evidence-informed policy making. Evidence-gap maps are thematic evidence collections covering a range of issues such as maternal health, HIV/AIDS, and agriculture. They present a visual overview of existing systematic reviews or impact evaluations in a sector or subsector, schematically representing the types of interventions evaluated and outcomes reported. Gap maps enable policy makers and practitioners to explore the findings and quality of the existing evidence and facilitate informed judgment and evidence-based decision making in international development policy and practice. The gap map also identifies key"gaps"where little or no evidence from impact evaluations and systematic reviews is available and where future research should be focused. Thus, gap maps can be a useful tool for developing a strategic approach to building the evidence base in a particular sector. This paper provides an introduction to evidence-gap maps, outlines the gap-map methodology, and presents some examples.
Is more better than less? An analysis of children's mental health services.

OBJECTIVE To assess the dose-response relationship for outpatient therapy received by children and adolescents-that is, to determine the impact of added outpatient visits on key mental health outcomes (functioning and symptomatology). DATA SOURCES/STUDY SETTING The results presented involve analyses of data from the Fort Bragg Demonstration and are based on a sample of 301 individuals using outpatient services. STUDY DESIGN This article provides estimates of the impact of outpatient therapy based on comparisons of individuals receiving differing treatment doses. Those comparisons involve standard multiple regression analyses as well as instrumental variables estimation. The latter provides a means of adjusting comparisons for unobserved or unmeasured differences among individuals receiving differing doses, differences that would otherwise be confounded with the impact of treatment dose. DATA COLLECTION/EXTRACTION METHODS Using structured diagnostic interviews and behavior checklists completed by the child and his or her caretaker, detailed data on psychopathology, symptomatology, and psychosocial functioning were collected on individuals included in these analyses. Information on the use of mental health services was taken from insurance claims and a management information system. Services data were used to describe the use of outpatient therapy within the year following entry into the study. PRINCIPAL FINDINGS/CONCLUSIONS Instrumental variables estimation indicates that added outpatient therapy improves functioning among children and adolescents. The effect is statistically significant and of moderate practical magnitude. These results imply that conventional analyses of the dose-response relationship may understate the impact of additional treatment on functioning. This finding is robust to choice of functional form, length of time over which outcomes are measured, and model specification. Dose does not appear to influence symptomatology.
Carbon Mitigation Policies, Distributional Dilemmas and Social Policies

Abstract Contemporary policies to reduce emissions of greenhouse gases (GHGs) will have distributive consequences and thus implications for the scope and remit of social policy. This paper studies current carbon mitigation policies and their distributive impacts. It considers a range of current and proposed social programmes to ameliorate these impacts, before proposing alternatives. This argument is pursued in two parts according to whether emissions are conceived and accounted within a production or a consumption framework. The first part works within the Kyoto policy framework, critiques the present suite of policies and suggests alternative policy scenarios that may better marry together the goals of carbon reduction and social equity. The second half justifies and operationalises a broader focus on all GHGs emitted by British consumers, whether directly or embodied in goods and services. It argues that to target these will require going beyond the current policy paradigm to develop more radical policies to modify preferences and behaviour, and to constrain total consumption demand. It then speculates on ways that new social policy programmes might combine the pursuit of these goals together with social equity.
Early fear memory defects are associated with altered synaptic plasticity and molecular architecture in the TgCRND8 Alzheimer's disease mouse model

Alzheimer's disease (AD) is a complex and slowly progressing dementing disorder that results in neuronal and synaptic loss, deposition in brain of aberrantly folded proteins, and impairment of spatial and episodic memory. Most studies of mouse models of AD have employed analyses of cognitive status and assessment of amyloid burden, gliosis, and molecular pathology during disease progression. Here we sought to understand the behavioral, cellular, ultrastructural, and molecular changes that occur at a pathological stage equivalent to the early stages of human AD. We studied the TgCRND8 mouse, a model of aggressive AD amyloidosis, at an early stage of plaque pathology (3 months of age) in comparison to their wildtype littermates and assessed changes in cognition, neuron and spine structure, and expression of synaptic glutamate receptor proteins. We found that, at this age, TgCRND8 mice display substantial plaque deposition in the neocortex and hippocampus and impairment on cued and contextual memory tasks. Of particular interest, we also observed a significant decrease in the number of neurons in the hippocampus. Furthermore, analysis of CA1 neurons revealed significant changes in apical and basal dendritic spine types, as well as altered expression of GluN1 and GluA2 receptors. This change in molecular architecture within the hippocampus may reflect a rising representation of inherently less stable thin spine populations, which can cause cognitive decline. These changes, taken together with toxic insults from amyloid‐β protein, may underlie the observed neuronal loss. J. Comp. Neurol. 522:2319–2335, 2014. © 2014 Wiley Periodicals, Inc.
THE VARYING EFFECTS OF LOCALITIES' ETHNIC PROFILE ON ETHNIC GROUPS' NON-ELECTORAL POLITICAL PARTICIPATION

A number of studies in the field of political geography have focused on the ethnic profile of the locality to examine its effect on political participation. Mainly focused on voter turnout and framed in the “hypersegregated” urban America, the research on the impact of the spatial distribution of ethnic groups barely studied its effects on alternative forms of political action in Britain. This paper claims that together with the economic features, the characteristics of the local distribution of ethnic minorities can account for individuals‟ degree of political engagement in non-electoral activities. I test three competing theories of segregation effects on participation, namely, the “Ethnic community", the “Group conflict” and the “Racial treat” models. For the empirical analysis, I pooled three rounds of the Citizenship Survey conducted in England in 2005, 2007 and 2009 and I fitted a set of multilevel logistic regression models for handling the nested data. Applying different measures of local segregation and diversity derived from Census data, I found that concentration of co-ethnic affects the main English ethnic groups‟ propensities to participate in any political activity. However, evidence suggests that the ethnic environment stimulates political activism differently depending on the ethnic category considered. This paper seeks to contribute to the current discussion on the causes and consequences of the spatial patterns of residence of ethnic populations in urban England.
Voter Attitudes and Public Spending: Is There a Relationship?*

The median voter model of how public expenditures are determined is discussed, as are alternative models, which soft-pedal the role of the electorate and elections in decision-making on public spending. The median voter proposition is tested and rejected empirically. The empirical relationship between voter attitudes towards public spending and actual spending is then related to the alternative models of how public expenditures are decided upon. The empirical analysis shows inconsistencies between item-by-item spending preferences and aggregate spending preferences. Further, political activists have a higher propensity to spend than the average voter.
Regulation, competition, and the structure of prices

Many competition policy issues in regulated industries concern the structure of prices charged by multiproduct firms--for example price discrimination, non-linear pricing, cross-subsidies, and network access pricing. This article first sets out the (Ramsey) principles of optimal pricing to recover fixed costs. The sometimes conflicting aims of promoting competition and pursuing social objectives are brought into the analysis. Questions of whether to allow pricing structure discretion to the firm, and how much, are considered next. With asymmetric information, some discretion is often desirable, but its optimal form is hard to characterize. The article then turns to the controversial network access pricing problem--on what terms should an integrated dominant firm be required to supply inputs required by its rivals? Finally, there is discussion of pricing structure regulation in the transition from more to less regulation, which, it is to be hoped, is in prospect in parts of the regulated industries as effective competition develops. Copyright 1997 by Oxford University Press.
Some Empirical Evidence on the Effects of Monetary Policy Shocks on Exchange Rates

This paper presents new empirical evidence on the effects of monetary policy shocks on U.S. exchange rates, both nominal and real. Three measures of monetary policy shocks are considered: orthogonalized shocks to the Federal Funds rate, the ratio of Non Borrowed to Total Reserves and the Romer and Romer (1989) index. Using data from the flexible exchange rate era, we find that expansionary shocks to U.S. monetary policy lead to sharp. persistent depreciations in U.S. nominal and real exchange rates as well as to sharp. persistent increases in the spread between various foreign and U.S. interest rates. The temporal pattern of the depreciation in U.S. nominal exchange rates following a positive monetary policy shock is inconsistent with simple overshooting models of the type considered by Dornbusch (1976). We also find that U.S. monetary policy was less volatile under fixed exchange rates than under floating exchange rates. Finally, we find less evidence that monetary policy shocks had a significant impact on U.S. real exchange rates under the Bretton Woods agreement.
Reciprocity vs. Free‐Riding in Innovation Contest Communities

Innovation contest communities are virtual tools for corporations to integrate external knowledge and creativity into the innovation process. Built on both the principle of competition and the advantages of a collaborative community, innovation contest communities constitute special interaction phenomena. The present study explores how different co‐operation behaviours, namely reciprocal giving, initial altruistic giving and free‐riding, influence the quality of participants' ideas on an open virtual contest platform with more than 2,000 members and more than 4,000 submissions. Our findings show that reciprocity and free‐riding are substantial behavioural elements of innovation contest communities leading to different outcomes regarding quality of submitted ideas. With this study, we contribute to a better theoretical understanding of distinctive types of co‐operation and free‐riding among individuals in the context of open innovation, extending theories of the evolution of co‐operation.