Miracle-dz/UniFAR-FTUs huggingface dataset:
Early tissue reaction at the interface of immediately loaded dental implants.

PURPOSE The treatment of patients with early or immediately loaded dental implants has renewed interest in the behavior of osteoblasts at the implant surface under load. A newly designed dental implant indicated for immediate loading was tested in vivo for early stages of osteoblast behavior at the implant surface. MATERIALS AND METHODS Thirty-two implants were placed in the mandibles of 8 minipigs. Half of the implants (n = 16) were immediately loaded under occlusal contacts, and implants placed in non-occlusal relations served as a control. RESULTS All implants, except 1 that showed signs of tissue infection, healed uneventfully and were stable throughout the experimental period. Ultrastructural analysis of mandibular specimens revealed an intimate attachment of osteoblasts to the material surface beginning as early as day 1. Application of either occlusal or non-occlusal load did not alter the phenotypic morphology of the attached osteoblasts. Transmission electron microscopy and x-ray diffraction analysis demonstrated a direct contact of bone-like minerals over the whole implant surface with no signs of crestal hard tissue alteration. Electron diffraction analysis showed a slight release of titanium from the implant side. DISCUSSION These results indicate that immediate loading of specially designed dental implants can be performed without disruption of the titanium/bone interface or disturbance of osteoblast physiology in the early loading phase. CONCLUSION Immediate loading protocols can be performed without disturbance of normal bone biology.
Expression Cloning of an Interferon-inducible 17-kDa Membrane Protein Implicated in the Control of Cell Growth (*)

Interferon-inducible membrane proteins of approximately 17 kDa have been suggested to play a role in the antiproliferative activity of interferons based on (1) their pattern of induction in interferon-sensitive and -resistant cell lines and (2) the ability of a membrane fraction enriched in 17-kDa proteins to inhibit cell growth. To gain insight into the nature of the proteins that mediate the antiproliferative activity of interferons, a monoclonal antibody, 13A5, was generated that reacted specifically with a 17-kDa interferon-inducible cell surface protein. The expression pattern of this 17-kDa protein by human cell lines correlated with sensitivity to the antiproliferative activity of interferons. To obtain information regarding the structure of this protein, the 13A5 antibody was used to screen COS cells transfected with a human cDNA expression library. Sequence analysis of a full-length cDNA clone revealed identity with the 9-27 cDNA, previously isolated on the basis of its interferon inducibility by differential screening. In addition, the 17-kDa protein encoded by the 9-27 gene was shown to be identical to the Leu-13 antigen. Leu-13 was previously identified as a 16-kDa interferon-inducible protein in leukocytes and endothelial cells and is a component of a multimeric complex involved in the transduction of antiproliferative and homotypic adhesion signals. These results suggest a novel level of cellular regulation by interferons involving a membrane protein, encoded by the interferon-inducible 9-27 gene, which associates with other proteins at the cell surface, forming a complex relaying growth inhibitory and aggregation signals.
ANALISIS HUBUNGAN KEPUASAN KERJA TERHADAP PRESTASI KERJA KARYAWAN

Kinerja merupakan suatu fungsi dari motivasi dan kemampuan. Untuk menyelesaikan tugas atau pekerjaan seseorang sepatutnya memiliki derajat kesediaan dan tingkat kemampuan tertentu. Kesediaan dan keterampilan seseorang tidaklah cukup efektif untuk mengerjakan sesuatu tanpa pemahaman yang jelas tentang apa yang akan dikerjakan dan bagaimana mengerjakannya. Kinerja merupakan perilaku nyata yang ditampilkan setiap orang sebagai prestasi kerja yang dihasilkan oleh karyawan sesuai dengan perannya dalam perusahaan. Kinerja karyawan merupakan suatu hal yang sangat penting dalam upaya perusahaan untuk mencapai tujuannya. DOI: 10.15408/aiq.v2i1. 2477
Design and Experimental Study of 4H-SiC Trenched Junction Barrier Schottky Diodes

This paper presents the design, fabrication, and experimental analysis of 1200 V 4H-SiC trenched junction barrier Schottky (TJBS) diodes. Design considerations and device performances of the TJBS devices are compared with those of the conventional planar JBS diodes via numerical simulation, analytical modeling, and experiments. It was found that, for conventional planar JBS diodes, due to its limited P+ implantation depth, there is a tight tradeoff between forward ON-resistance and blocking voltage. This does not only put stringent requirement on obtaining a narrow photolithography line width (~1.5 μm), but also makes the device design window narrow. The TJBS diodes can substantially alleviate such tradeoff and obtain a larger design window that enables good reverse blocking and forward conduction capabilities at the same time. As a result, this structure demands less restriction on line width control (2.2-3.2 μm) of the fabrication process and hence can improve the device yield.
Ruminally protected lysine and methionine for lactating dairy cows fed a diet designed to meet requirements for microbial and postruminal protein.

Dairy cows, 20 at each of two sites, were used to determine responses to ruminally protected Lys and Met in a full lactation study. Cows were fed corn silage twice daily for ad libitum intake and a concentrate four times daily in proportion to milk production. At Truro, cows were fed 2.7 kg/d of alfalfa and timothy hay DM at 0600 and at 1500 h. At Fredericton, cows were fed 2.7 kg of timothy silage DM at 0600 h and 2.7 kg of alfalfa hay DM at 1500 h. Diets were designed to meet, but not to exceed, recommendations for ruminally degradable CP and intestinally digestible protein. Ten cows at each site were fed ruminally protected L-Lys.HCl (19 g/d) and DL-Met (6.5 g/d). Cows fed AA at each site produced more milk, lactose, protein, and fat; milk protein and fat percentages were also higher. No time x treatment interactions occurred for any production parameter. In spite of similar production responses between sites, cows fed AA consumed more DM at Truro, but those at Fredericton did not. Thus, gross efficiency of utilization of dietary N for milk N was increased with AA at Fredericton but not at Truro. However, considering the increased intake of CP by cows fed AA at Truro, an event that would have been expected to depress efficiency of utilization of dietary N, the lack of difference at Truro between treatments can be interpreted as an improvement, relative to expectations, because of AA feeding. High producing dairy cows fed a diet that was adequate in CP responded to ruminally protected Lys and Met primarily with increased production of milk protein and fat throughout the full lactation.
THE BELGIAN 2010 CONSENSUS RECOMMENDATIONS FOR THE TREATMENT OF MULTIPLE MYELOMA

Abstract Since the introduction of novel therapeutic agents including thalidomide, lenalidomide and bortezomib, the prognosis of multiple myeloma (MM) has significantly improved. These agents have been incorporated into numerous treatment schedules for newly diagnosed as well as more advanced MM patients. Hence, the therapeutic options for MM have become more complex and subject to rapid changes. The multiple myeloma study group (MMSG) of the Belgian Hematological Society has established recommendations for the treatment of MM as based on an extensive review of the literature which is also summarized in this paper. The recommendations are the result of a consensus opinion between haematologists with experience in the field and representing most haematology centres in Belgium. Where applicable, reimbursement criteria are also taken into account. The consensus recommendations should be a reference for use by clinical haematologists in daily practice.
The Relationship between Academic Advising and Student Success in Canadian Colleges: A Review of the Literature.

Increasing student retention is complex and no one single intervention can independently solve the student success problem; however, academic advising has been cited more prominently in student success literature as a central feature in a comprehensive strategy to improve student persistence, especially on college campuses. This paper explores current literature on academic advising, its relationship with student success, and the current state of the literature in Canada. Findings include that there is very little research showing the direct effect of academic advising on student success, and that only on rare occasion does this research employ rigorous analytical and design methods. It is also argued that the organization and practice of academic advising in Canada is still in its infancy. Implications for future research and practice are also presented.
Calcium currents, transmitter release and facilitation of release at voltage‐clamped crayfish nerve terminals.

1. The presynaptic terminals at crayfish (Procambarus spp.) opener neuromuscular junctions were voltage clamped. Calcium currents were measured during (ICa) and following (tail ICa) presynaptic depolarizations; EPSPs or IPSPs were simultaneously recorded from the (postsynaptic) muscle fibre directly beneath the presynaptic impalement. 2. For short (< or = 6 ms) presynaptic depolarizations, most of the transmitter release occurred during the tail ICa. EPSP or IPSP amplitudes at the end of the 6 ms pulse (end EPSP or end IPSP) increased monotonically with the integral of the ICa ([symbol: see text]ICa). The suppression potential for transmitter release was near the apparent reversal potential for ICa. 3. When the end EPSP or end IPSP amplitude was plotted against the peak ICa elicited during a presynaptic pulse (peak ICa), large and small depolarizations which evoked the same peak ICa evoked different amounts of transmitter release. The differences in transmitter release were eliminated when end EPSP amplitude was plotted against [symbol: see text] ICa, suggesting that transmitter release during a depolarization depends only upon calcium current and not upon a subsequent voltage‐dependent step. 4. The synaptic transfer function of various measurements of EPSP or IPSP amplitude vs. [symbol: see text]ICa evoked during a presynaptic depolarization was a power function having an exponent of about 3. Similar measurements of EPSP amplitude vs. [symbol: see text]tail ICa evoked following a presynaptic depolarization had an exponent of about 2. 5. Facilitation of an EPSP or IPSP was not due to increases in calcium current at the test depolarization. 6. When the conditioning depolarization was increased and the test depolarization remained constant, EPSP amplitude at the test depolarization and facilitation increased . When the conditioning depolarization remained constant and the test depolarization was increased, EPSP amplitude at the test depolarization increased, while facilitation decreased. 7. Our data suggested that transmitter release at crayfish neuromuscular junctions is a non‐linear function of calcium influx, and that facilitated release utilizes intracellular calcium differently from non‐facilitated release. These data contradict simple models of facilitation which combine the residual calcium hypothesis with the calcium co‐operativity hypothesis of non‐facilitated release.
Endemic human fasciolosis in the Bolivian Altiplano

SUMMARY Fasciolosis, caused by trematodes of the genus Fasciola, is an emerging disease of humans. One of the highest levels of human fasciolosis hepatica is found amongst the indigenous Aymaran people of the Northern Bolivian Altiplano. A meta-analysis of epidemiological surveys from 38 communities in the region demonstrates that fasciolosis has been endemic in the region since at least 1984 and is a zoonosis of rural communities. Human and bovine fasciolosis is associated with the communities lying in the plain from Lake Titicaca to La Paz, predominantly in the Los Andes province. In Los Andes incidences of up to 67% of population cohorts were found, and prevalence is age-related with the highest infection rate in children aged 8–11 years.
Diabetes mellitus type 2 and subsite-specific colorectal cancer risk in men and women: results from the Netherlands Cohort Study on diet and cancer

Background Type 2 diabetes mellitus (T2DM) is associated with an increased risk of colorectal cancer (CRC); however, studies differentiating between subsites of CRC are limited. We investigated how diabetes mellitus (DM) was associated with subsite-specific CRC risk in men and women. Methods The Netherlands Cohort Study on diet and cancer is a prospective study among 120 852 men and women aged 55–69 years old at baseline in 1986. Information on DM, anthropometric, dietary and lifestyle factors was self-reported at baseline. T2DM was defined as the diagnosis of DM after 30 years of age. Incident CRC cases were identified by record linkage with the Netherlands cancer registry and the Dutch pathology registry. After 17.3 years of follow-up, 1735 incident male CRC cases and 1321 female CRC cases were available for analyses. Subsite-specific hazard ratios (HRs) for CRC were estimated in case–cohort analyses using Cox regression. Results At baseline, 3.1% of subcohort members reported T2DM, of whom 80% were diagnosed after 50 years of age. Multivariable-adjusted models showed that the risk of proximal colon cancer was significantly increased in women with T2DM versus women without T2DM (HR=1.80, 95% confidence interval: 1.10–2.94). There was no association between T2DM and the risk of overall CRC, distal colon cancer and rectal cancer in women. In men, T2DM was not associated with overall CRC (HR=0.98, 95% confidence interval: 0.64–1.50), or with risk at any subsite. Conclusions This prospective study showed an increased risk of proximal colon cancer in women with T2DM compared with non-T2DM women.
Recall of Dental Pain and Anxiety in a Cohort of Oral Surgery Patients

Dental patients generally recall more pain than they originally report, with ratings of pain related to state anxiety and dental fear, but the role of depression in recall of dental pain remains uncertain. This study examined the relative contributions of different variables in explaining dental pain recalled after tooth extraction. Patients presenting for tooth extraction, prior to extraction, rated their current dental pain and state anxiety, prediction of pain and state anxiety during extraction, depression, and dental fear. Immediately postprocedure and then 1 mo later, patients rated their pain and state anxiety during extraction. Hierarchical linear regression equations were used to explain variance in recalled pain and state anxiety. In addition, patients were divided into high and low dental fear and depression groups and compared on ratings of pain and state anxiety across time. In a final sample of 157 patients, the most important predictors of recalled pain were pain reported during extraction (β = .53) and recalled state anxiety (β = .52). Dental fear and depression had a significant interaction: only when patients reported less depression did those patients who reported more dental fear also report more pain than patients who reported less dental fear (P < 0.05, ω2 = .07). Patients who reported more depression entered the dental operatory reporting more pain, but all patients generally reported less pain during extraction than they predicted or recalled. Memory of state anxiety and pain reported during tooth extraction, not depression or state anxiety at the time of extraction, were critical factors in memory of the pain associated with the procedure. At higher levels of depression, patients higher and lower in dental fear did not differ in report of pain. Future studies are needed to further clarify interactions of depression and dental fear over time.
Liquidity, Information Aggregation, and Market-Based Pay in an Efficient Market

This paper studies the usefulness of making the income of a CEO depend on the stock price of the firm he runs. We assume the stock market is efficient and find that other public information about CEO performance, e.g., accounting information, is not used to determine CEO pay. But because of the feedback loop between CEO actions and the stock price, the price does not fully reflect the consequences of CEO shirking for the value of the firm. The optimal incentive contract increases stock-based pay in order to increase the sensitivity of CEO income to shirking and thus deter it. This effect is stronger when traders have worse information, which can explain the prevalence of stock-based pay in hard-to-value firms. Our model derives a measure of the wedge between financial and economic efficiency, and generates new insights about the role of market conditions such as liquidity for optimal pay contracts.
Influence of fuel ethanol content on primary emissions and secondary aerosol formation potential for a modern flex-fuel gasoline vehicle

Abstract. The effect of fuel ethanol content (10, 85 and 100 %) on primary emissions and on subsequent secondary aerosol formation was investigated for a Euro 5 flex-fuel gasoline vehicle. Emissions were characterized during a New European Driving Cycle (NEDC) using a comprehensive set-up of high time-resolution instruments. A detailed chemical composition of the exhaust particulate matter (PM) was studied using a soot particle aerosol mass spectrometer (SP-AMS), and secondary aerosol formation was studied using a potential aerosol mass (PAM) chamber. For the primary gaseous compounds, an increase in total hydrocarbon emissions and a decrease in aromatic BTEX (benzene, toluene, ethylbenzene and xylenes) compounds was observed when the amount of ethanol in the fuel increased. In regard to particles, the largest primary particulate matter concentrations and potential for secondary particle formation was measured for the E10 fuel (10 % ethanol). As the ethanol content of the fuel increased, a significant decrease in the average primary particulate matter concentrations over the NEDC was found. The PM emissions were 0.45, 0.25 and 0.15 mg m−3 for E10, E85 and E100, respectively. Similarly, a clear decrease in secondary aerosol formation potential was observed with a larger contribution of ethanol in the fuel. The secondary-to-primary PM ratios were 13.4 and 1.5 for E10 and E85, respectively. For E100, a slight decrease in PM mass was observed after the PAM chamber, indicating that the PM produced by secondary aerosol formation was less than the PM lost through wall losses or the degradation of the primary organic aerosol (POA) in the chamber. For all fuel blends, the formed secondary aerosol consisted mostly of organic compounds. For E10, the contribution of organic compounds containing oxygen increased from 35 %, measured for primary organics, to 62 % after the PAM chamber. For E85, the contribution of organic compounds containing oxygen increased from 42 % (primary) to 57 % (after the PAM chamber), whereas for E100 the amount of oxidized organics remained the same (approximately 62 %) with the PAM chamber when compared to the primary emissions.
Supercritical CO2 Extraction of Lavandula angustifolia Mill. Flowers: Optimisation of Oxygenated Monoterpenes, Coumarin and Herniarin Content.

INTRODUCTION Lavandula angustifolia is good source of oxygenated monoterpenes containing coumarins as well, which are all soluble in supercritical CO2 (SC-CO2 ). OBJECTIVE The study objective is to investigate SC-CO2 extraction parameters on: the total yield; GC-MS profile of the extracts; relative content of oxygenated monoterpenes; the amount of coumarin and herniarin; and to determine optimal SC-CO2 extraction conditions by response surface methodology (RSM). METHODOLOGY SC-CO2 extraction was performed under different pressure, temperature and CO2 flow rate determined by Box-Behnken design (BBD). The sample mass and the extraction time were kept constant. The chemical profiles and relative content of oxygenated monoterpenes (as coumarin equivalents, CE) were determined by GC-MS. Coumarin and herniarin concentrations were dosed by HPLC. RESULTS SC-CO2 extracts contained linalool (57.4-217.9 mg CE/100 g), camphor (10.6-154.4 mg CE/100 g), borneol (6.2-99.9 mg CE/100 g), 1,8-cineole (5.0-70.4 mg CE/100 g), linalyl acetate (86.1-267.9 mg CE/100 g), coumarin (0.95-18.16 mg/100 g), and herniarin (0.95-13.63 mg/100 g). The interaction between the pressure and CO2 flow rate as well as between the temperature and CO2 flow rate showed statistically significant influence on the extraction yield. Applying BBD, the optimum extraction conditions for higher monoterpenes and lower coumarin content were at 10 MPa, 41°C and CO2 flow rate 2.3 kg/h, and at 30 MPa, 50°C and CO2 flow rate 3 kg/h for higher monoterpenes and coumarin content. CONCLUSION SC-CO2 extraction is a viable technique for obtaining lavender extracts with desirable flavour components. The second-order model based on BBD predicts the results for SC-CO2 extraction quite satisfactorily. Copyright © 2017 John Wiley & Sons, Ltd.
Relationship between oral health-related quality of life, satisfaction, and personality in patients with prosthetic rehabilitations.

PURPOSE This study investigated the relationship between oral health-related quality of life, satisfaction with dentition, and personality profiles among patients with fixed and/or removable prosthetic rehabilitations. MATERIALS AND METHODS Thirty-seven patients (13 males, 24 females; mean age 37.6 +/- 13.3 years) with fitted prosthetic rehabilitations and 37 controls who matched the patients by age and gender were recruited into the study. The Dental Impact on Daily Living (DIDL) questionnaire was used to assess dental impacts on daily living and satisfaction with the dentition. The Oral Health Impact Profile (OHIP) was used to measure self-reported discomfort, disability, and dysfunction caused by oral conditions. Oral health-related quality of life was assessed by the United Kingdom Oral Health-Related Quality of Life (OHQoL-UK) measure. Moreover, the NEO five-factor inventory was used to assess participants' personality profiles. RESULTS Prosthetic factors had no relationship to the DIDL, OHIP, and OHQoL-UK scores. Patients with the least oral health impacts had better oral health-related quality of life (p= 0.023, r =-0.37), higher levels of total satisfaction, and satisfaction with appearance, pain, oral comfort, general performance, and eating (p < 0.05, r =-0.79, -0.35, -0.59, -0.56, -0.58, and -0.50, respectively). Patients with better oral health-related quality of life (QoL) had higher total satisfaction, satisfaction with oral comfort, general performance, and eating (p < 0.05, r = 0.34, 0.39, 0.33, and 0.37, respectively). Patients with lower neuroticism scores had less oral health impact (p= 0.006, r = 0.44), better oral health-related QoL (p= 0.032, r =-0.35), higher total satisfaction, satisfaction with appearance, pain, oral comfort, and eating (p < 0.05, r =-0.58, -0.35, -0.33, -0.39, and -0.35, respectively). CONCLUSION Patients' satisfaction with their dentition and prosthetic rehabilitations has positive effects on oral health-related QoL and oral health impacts and improves patients' daily living and dental perceptions. Neuroticism might influence and predict patients' satisfaction with their dentition, oral health impacts, and oral health-related QoL. Satisfaction with the dentition might predict a patient's level of neuroticism.