Miracle-dz/UniFAR-FTUs huggingface dataset:
Nile Tilapia Derived TP4 Shows Broad Cytotoxicity toward to Non-Small-Cell Lung Cancer Cells

Non-small cell lung cancer (NSCLC) is among the leading causes of human mortality due to a lack of effective treatments. Conventional chemotherapies affect healthy cells and cause multidrug resistance, while tumors may eventually develop resistance to less-toxic targeted therapies. Thus, the need to develop novel therapies for NSCLC is urgent. Here, we show that Nile tilapia-derived Tilapia piscidin (TP) 4 is cytotoxic to a panel of NSCLC cells with different genetic profiles. We observed that TP4 triggers NSCLC cell death through the necrosis and combining TP4 with potent Epidermal growth factor receptor (EGFR)- tyrosine kinase inhibitors (TKI)s, Erlotinib, and Gefitinib, improved drug responses in EGFR-mutated NSCLC cells, but not in EGFR-wild-type NSCLC cells. This work provides novel insights into potential NSCLC treatments, which may utilize antimicrobial peptide TP4 as monotherapy or in combination with EGFR-TKIs.
Relationship between the Implicit Association Test and intergroup behavior: A meta-analysis.

Using data from 217 research reports (N = 36,071, compared to 3,471 and 5,433 in previous meta-analyses), this meta-analysis investigated the conceptual and methodological conditions under which Implicit Association Tests (IATs) measuring attitudes, stereotypes, and identity correlate with criterion measures of intergroup behavior. We found significant implicit-criterion correlations (ICCs) and explicit-criterion correlations (ECCs), with unique contributions of implicit (β = .14) and explicit measures (β = .11) revealed by structural equation modeling. ICCs were found to be highly heterogeneous, making moderator analyses necessary. Basic study features or conceptual variables did not account for any heterogeneity: Unlike explicit measures, implicit measures predicted for all target groups and types of behavior, and implicit, but not explicit, measures were equally associated with behaviors varying in controllability and conscious awareness. However, ICCs differed greatly by methodological features: Studies with a declared focus on ICCs, standard IATs rather than variants, high-polarity attributes, behaviors measured in a relative (two categories present) rather than absolute manner (single category present), and high implicit-criterion correspondence (k = 13) produced a mean ICC of r = . 37. Studies scoring low on these variables (k = 6) produced an ICC of r = . 02. Examination of methodological properties-a novelty of this meta-analysis-revealed that most studies were vastly underpowered and analytic strategies regularly ignored measurement error. Recommendations, along with online applications for calculating statistical power and internal consistency are provided to improve future studies on the implicit-criterion relationship. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
Iron Biofortified Carioca Bean (Phaseolus vulgaris L.)—Based Brazilian Diet Delivers More Absorbable Iron and Affects the Gut Microbiota In Vivo (Gallus gallus)

Biofortification aims to improve the micronutrient concentration and bioavailability in staple food crops. Unlike other strategies utilized to alleviate Fe deficiency, studies of the gut microbiota in the context of Fe biofortification are scarce. In this study, we performed a 6-week feeding trial in Gallus gallus (n = 15), aimed to investigate the Fe status and the alterations in the gut microbiome following the administration of Fe-biofortified carioca bean based diet (BC) versus a Fe-standard carioca bean based diet (SC). The tested diets were designed based on the Brazilian food consumption survey. Two primary outcomes were observed: (1) a significant increase in total body Hb-Fe values in the group receiving the Fe-biofortified carioca bean based diet; and (2) changes in the gut microbiome composition and function were observed, specifically, significant changes in phylogenetic diversity between treatment groups, as there was increased abundance of bacteria linked to phenolic catabolism, and increased abundance of beneficial SCFA-producing bacteria in the BC group. The BC group also presented a higher intestinal villi height compared to the SC group. Our results demonstrate that the Fe-biofortified carioca bean variety was able to moderately improve Fe status and to positively affect the intestinal functionality and bacterial populations.
Interleukin-10 and Transforming Growth Factor-β in Early and Late Lesions of Patients with Leishmania major Induced Cutaneous Leishmaniasis

Background Cutaneous leishmaniasis is a neglected parasitic disease, which imposes massive human distress and financial costs to the endemic countries. Better understanding of host immune response to the parasite leads to helpful strategies for disease control. Interleukin (IL)-10 and transforming growth factor (TGF)-β are important immune regulatory cytokines, which appear to develop non-healing forms of leishmaniasis. However, there is little information about the function of IL-10 and TGF-β in old world cutaneous leismaniasis. The aim of this study was to analyze the role of IL-10 and TGF-β in human cutaneous leishmaniasis due to Leishmania major infection. Methods Biopsies were obtained from lesions of twenty proven cases of L. major induced cutaneous leishmaniasis. IL-10 and TGF-β positive cells were detected by immunofluorescence staining of frozen sections and compared between two groups of patients with early and late lesions. Results The mean percentage of IL-10 positive cells were significantly (P= 0.035) higher in late lesions (0.51±0.24) than early ones (0.15±0.07). Similar results were obtained for TGF-β with mean percentages of 0.16±0.05 and 0.53±0.28 in early and late lesions respectively (P= 0.008). Conclusion IL-10 and TGF-β are present in lesions of L. major induced cutaneous leishmaniasis and contribute to the pathogenesis of long lasting disease forms.
Exploring the mediating role of self-blame and coping in the relationships between self-compassion and distress in females following the sexual assault.

OBJECTIVE The present study investigated the associations between self-compassion, self-blame, disengagement coping, and posttraumatic stress disorder (PTSD) and depression symptom severity among females who had experienced sexual assault. We also examined whether the relationships between self-compassion and both PTSD and depression severity were mediated by self-blame and coping. METHOD A volunteer sample of female adults (N = 207) completed surveys online or on paper. RESULTS Mediational analyses showed that higher self-compassion was associated with lower behavioral self-blame, characterological self-blame (CSB), and disengagement coping which, in turn, were associated with less PTSD. Higher self-compassion was associated with less depression severity directly and indirectly via CSB. CONCLUSIONS These findings suggest that self-compassion may be relevant for understanding postassault mental health, partially through its associations with self-blame and coping. Clinicians working with sexual assault survivors may choose to augment treatment-as-usual with interventions designed to increase self-compassion.
Image-based classification of bladder state using electrical impedance tomography

Objective: In this study, we examine the potential of using machine learning classification to determine the bladder state (‘not full’, ‘full’) with electrical impedance tomography (EIT) images of the pelvic region. Accurate classification of these states would enable urinary incontinence (UI) monitoring to alert the patient, before involuntary voiding occurs, in a low-cost and discrete manner. Approach: Using both numerical and experimental data, we form datasets that contain diverse observations with varying clinical parameters such as bladder volume, urine conductivity, and the reference used for time-difference imaging. We then classify the bladder state using both pixel-wise and feature extraction-based classification techniques. We employ principal component analysis, wavelets, and image segmentation to help create features. Main results: The performance was compared across several classifier algorithms. The minimum accuracy was 77.50%. The highest accuracy observed was 100%, and was found by combining principal component analysis and the Gaussian radial based function kernel support vector machine. This combination also offered the best trade-off between classification performance and the costs of training time and memory space. The biggest challenge in bladder state classification is classifying volumes near the separation volume of not full and full, in which choosing the most suitable classifier combination can minimize this error. Significance: We performed the first machine learning classification of bladder EIT images, achieving high classification accuracies with both numerical and experimental data. This work highlights the potential of using image-based machine learning with an EIT device to support bladder monitoring for those suffering from UI.
Current Research and New Perspectives of Telemedicine in Chronic Heart Failure: Narrative Review and Points of Interest for the Clinician

Background: This is a narrative review of both the literature and Internet pertaining to telemedicine projects within the field of heart failure, with special attention placed on remote monitoring of second-generation projects and trials, particularly in France. Results: Since the beginning of the 2000’s, several telemedicine projects and trials focused on chronic heart failure have been developed. The first telemedicine projects (e.g., TEN-HMS, BEAT-HF, Tele-HF, and TIM-HF) primarily investigated telemonitoring or for the older ones, telephone follow-up. Numerous second-generation telemedicine projects have emerged in Europe over the last ten years or are still under development for computer science heart failure, especially in Europe, such as SCAD, OSICAT, E-care, PRADO-INCADO, and TIM-HF2. The E-care telemonitoring project fits within the telemedicine 2.0 framework, based on connected objects, new information and communication technologies (ICT) and Web 2.0 technologies. E-care is the first telemedicine project including artificial intelligence (AI). TIM-HF2 is the first positive prospective randomized study with regards to EBM with positive significant clinical benefit, in terms of unplanned cardiovascular hospital admissions and all-cause deaths. The potential contribution of second-generation telemedicine projects in terms of mortality, morbidity, and number of hospitalizations avoided is currently under study. Their impact in terms of health economics is likewise being investigated, taking into account that the economic and social benefits brought up by telemedicine solutions were previously validated by the original telemedicine projects.
Modeling on Fragmentation of Clusters inside a Mass Spectrometer

Atmospheric clusters are weakly bound and can fragment inside the measuring instruments, in particular, mass spectrometers. Since the clusters accelerate under electric fields, the fragmentation cannot be described in terms of rate constants under equilibrium conditions. Using basic statistical principles, we have developed a model for fragmentation of clusters moving under an external force. The model describes an energy transfer to the cluster internal modes caused by collisions with residual carrier gas molecules. As soon as enough energy is accumulated in the cluster internal modes, it can fragment. The model can be used for interpreting experimental measurements by atmospheric pressure interface mass spectrometers.
High-grade Endometrial Carcinomas: Morphologic and Immunohistochemical Features, Diagnostic Challenges and Recommendations

This review of challenging diagnostic issues concerning high-grade endometrial carcinomas is derived from the authors’ review of the literature followed by discussions at the Endometrial Cancer Workshop sponsored by the International Society of Gynecological Pathologists in 2016. Recommendations presented are evidence-based, insofar as this is possible, given that the levels of evidence are weak or moderate due to small sample sizes and nonuniform diagnostic criteria used in many studies. High-grade endometrioid carcinomas include FIGO grade 3 endometrioid carcinomas, serous carcinomas, clear cell carcinomas, undifferentiated carcinomas, and carcinosarcomas. FIGO grade 3 endometrioid carcinoma is diagnosed when an endometrioid carcinoma exhibits >50% solid architecture (excluding squamous areas), or when an architecturally FIGO grade 2 endometrioid carcinoma exhibits marked cytologic atypia, provided that a glandular variant of serous carcinoma has been excluded. The most useful immunohistochemical studies to make the distinction between these 2 histotypes are p53, p16, DNA mismatch repair proteins, PTEN, and ARID1A. Endometrial clear cell carcinomas must display prototypical architectural and cytologic features for diagnosis. Immunohistochemical stains, including, Napsin A and p504s can be used as ancillary diagnostic tools; p53 expression is aberrant in a minority of clear cell carcinomas. Of note, clear cells are found in all types of high-grade endometrial carcinomas, leading to a tendency to overdiagnose clear cell carcinoma. Undifferentiated carcinoma (which when associated with a component of low-grade endometrioid carcinoma is termed “dedifferentiated carcinoma”) is composed of sheets of monotonous, typically dyscohesive cells, which can have a rhabdoid appearance; they often exhibit limited expression of cytokeratins and epithelial membrane antigen, are usually negative for PAX8 and hormone receptors, lack membranous e-cadherin and commonly demonstrate loss of expression of DNA mismatch repair proteins and SWI-SNF chromatin remodeling proteins. Carcinosarcomas must show unequivocal morphologic evidence of malignant epithelial and mesenchymal differentiation.
Strategies to improve bioavailability of omega-3 fatty acids from ethyl ester concentrates

Purpose of review To describe recent strategies that have been developed to enhance absorption of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) from dietary supplements. Recent findings The long-chain omega-3 fatty acids EPA and DHA have important physiologic functions, and numerous potential health benefits have been suggested by results from observational studies and randomized, controlled trials. EPA and DHA intakes in the average American diet are substantially below recommended levels. Dietary supplements are available for consumers wishing to increase their intakes, but many of these are in ethyl ester formulations from which EPA and DHA are poorly absorbed when consumed without a meal containing dietary fat. Technologies have been developed to enhance EPA and DHA absorption through in-situ emulsification, which facilitates bioavailability, even in the absence of a fat-containing meal. Findings from randomized controlled trials of absorption enhancers incorporated into omega-3 fatty acid supplements demonstrate that they can markedly improve the bioavailability of EPA and DHA. Summary The development of absorption enhancement technology to increase bioavailability of long-chain omega-3 fatty acids has important implications for studies on the health effects of dietary supplement and pharmaceutical products containing EPA and/or DHA.
Serum bile acid patterns are associated with the presence of NAFLD in twins, and dose‐dependent changes with increase in fibrosis stage in patients with biopsy‐proven NAFLD

The fasting‐state serum bile acid profile in nonalcoholic fatty liver disease (NAFLD) has been reported to differ when nonalcoholic steatohepatitis is compared to nonalcoholic fatty liver. However, there are few data comparing changes in NAFLD vs non‐NAFLD, or whether the bile acid profile differs according to the degree of fibrosis.
REPLICA PLATING AND INDIRECT SELECTION OF BACTERIAL MUTANTS

Elective enrichment is an indispensable technique in bacterial physiology and genetics (van Niel, 1949). Specific biotypes are most readily isolated by the establishment of cultural conditions that favor their growth or survival. It has been repeatedly questioned, however, whether a selective environment may not only select but also direct adaptive heritable changes. In accord with similar discussions in evolutionary biology (Huxley, 1942), we may denote the concepts of spontaneous mutation and natural selection in contrast to specific induction as "preadaptation" and "directed mutation", respectively. Many lines of evidence have been adduced in support of preadaptation in a variety of systems (Luria and Delbruick, 1943; Lea and Coulson, 1949; Burnet, 1929; Newcombe, 1949; Lewis, 1934; Kristensen, 1944; Novick and Szilard, 1950; Ryan and Schneider, 1949; Demerec, 1948; Welsch, 1950; also reviewed: Braun, 1047; Luria, 1947; Lederberg, 1948, 1949). This paper concerns an approach to this problem that makes use of a replica plating technique which facilitates the handling of large numbers of bacterial clones for classification on a variety of media.
Self-control development in adolescence predicts love and work in adulthood.

This longitudinal study over a 23-year time span examined predictive associations between self-control development in adolescence and love and work outcomes in adulthood. Participants were 1,527 adults aged 35 years (48.3% female). The predictor variable self-control was measured yearly at the ages of 12 to 16 years. Adult outcome variables were measured at the age of 35 years. Three important results stand out. First, the measure of adolescent self-control functioned equivalently across the adolescent years. Second, adolescents showed a mean-level increase in self-control across the adolescent years and significant individual differences in level and change of self-control. Finally, individual differences in change in adolescent self-control predicted better intimate relationships in terms of higher relationship satisfaction and lower conflict; and more satisfaction and engagement in work-life in adulthood independent of the initial levels of self-control in early adolescence. These findings demonstrate that developmental self-regulatory processes reveal long-term consequences in important life domains beyond the adolescent years. (PsycINFO Database Record (c) 2018 APA, all rights reserved).
CardioFi: Enabling Heart Rate Monitoring on Unmodified COTS WiFi Devices

Heart rate is one of the most important vital signals for personal health tracking. A number of approaches were proposed to monitor heart rate, ranging from wearables to device-less systems. While WiFi has been shown to track heart rate accurately, existing solutions rely on directional antennas to improve the signal quality and ultimately the accuracy of heart rate estimation. Special hardware used in these approaches limits their applicability and truly device-less and ubiquitous heart rate monitoring is yet to be achieved. In this paper, we propose CardioFi: a system that can accurately monitor vital signs through COTS WiFi hardware with omnidirectional antennas. Our key challenge is the substantial radio frequency noise that affects WiFi transmissions in real-world environments. However, we observe that a few sub-carriers are typically less affected by multipath and the heart beating motion can be accurately detected in their frequency spectrum. We present a novel sub-carrier selection scheme that allows us to detect and amplify signal from these sub-carriers even in low signal-to-noise ratio scenarios. We show that CardioFi estimates heart rate with 1.1 beats per minute (bpm) median error, which compares favorably with systems equipped with directional antennas. Furthermore, we show that state-of-art heart rate estimation algorithms do not perform well in low SNR scenarios and CardioFi improves their 50- and 90-th percentile error by 40% and 176%, respectively.
A multigene typing system for human adenoviruses reveals a new genotype in a collection of Swedish clinical isolates

Human adenoviruses (HAdVs) are common pathogens that can cause respiratory, gastrointestinal, urogenital, and ocular infections. They are divided into seven species containing 85 genotypes. Straightforward typing systems might help epidemiological investigations. As homologous recombination frequently shapes the evolution of HAdVs, information on a single gene is seldom sufficient to allow accurate and precise typing, and complete genome-based methods are recommended. Even so, complete genome analyses are not always easy to perform for practical reasons, and in such cases a multigene system can provide considerably more information about the strain under investigation than single-gene-based methods. Here we present a rapid, generic, multigene typing system for HAdVs based on three main deterministic regions of these viruses. Three PCR systems were used to amplify the genes encoding the DNA polymerase, the penton base hypervariable Arg-Gly-Asp-containing loop, and the hexon loop 1 (hypervariable region 1–6). Using this system, we typed 281 clinical isolates, detected members of six out of seven HAdV species (Human mastadenovirus A–F), and could also detect not only divergent strains of established types but also a new recombinant strain with a previously unpublished combination of adenovirus genomes. This strain was accepted by the Human Adenovirus Working Group as a novel genotype: HAdV-86. Seven strains that could not be typed with sufficient accuracy were also investigated using a PCR based on part of the fiber gene. By analysis of corresponding sequences of the 86 known HAdV genotypes, we determined that the proposed typing system should be able to distinguish all non-recombinant types, and with additional fiber information, all known HAdV genotypes.
The intuitive greater good: Testing the corrective dual process model of moral cognition.

Building on the old adage that the deliberate mind corrects the emotional heart, the influential dual process model of moral cognition has posited that utilitarian responding to moral dilemmas (i.e., choosing the greater good) requires deliberate correction of an intuitive deontological response. In the present article, we present 4 studies that force us to revise this longstanding "corrective" dual process assumption. We used a two-response paradigm in which participants had to give their first, initial response to moral dilemmas under time-pressure and cognitive load. Next, participants could take all the time they wanted to reflect on the problem and give a final response. This allowed us to identify the intuitively generated response that preceded the final response given after deliberation. Results consistently show that in the vast majority of cases (+ 70%) in which people opt for a utilitarian response after deliberation, the utilitarian response is already given in the initial phase. Hence, utilitarian responders do not need to deliberate to correct an initial deontological response. Their intuitive response is already utilitarian in nature. We show how this leads to a revised model in which moral judgments depend on the absolute and relative strength differences between competing deontological and utilitarian intuitions. (PsycINFO Database Record (c) 2018 APA, all rights reserved).