Miracle-dz/UniFAR-FTUs huggingface dataset:
The relationship between continuity of care and trust with stage of cancer at diagnosis.

BACKGROUND AND OBJECTIVES While continuity of care has been associated with an increased rate of cancer screening, it is unclear if continuity leads to earlier detection of cancer. This study examined the relationship between continuity of care and trust in one's physician with stage of cancer among newly diagnosed colorectal and breast cancer patients. METHODS A total of 119 newly diagnosed cancer patients (97 breast, 22 colorectal) were surveyed in face-to-face interviews. The relationship between continuity of care and trust with the patient's primary care physicians prior to diagnosis were examined in relationship to the patient's stage at diagnosis via Spearman correlations and chi-square analyses. A stepwise logistic regression model was computed to examine the best predictors of stage at diagnosis. RESULTS Half of the patients reported that their cancer was found through screening. Continuity of care prior to diagnosis was related to receiving mammography. Continuity of care was not, however, significantly related to earlier detection. Trust in one's primary care physician was related to earlier detection among both the entire sample of patients with colon and breast cancer and among a subsample of women with breast cancer. In a multivariate model, only detection through screening and trust predicted stage of diagnosis. CONCLUSIONS Continuity of care is not related to earlier detection of cancer, while trust with a regular physician was associated with earlier detection of cancer.
Inflation: Concepts, Evolution, and Correlates

In the past four to five decades, inflation has fallen around the world, with median annual global consumer price inflation down from a peak of 16.6 percent in 1974 to 2.6 percent in 2017. This decline began in advanced economies in the mid-1980s and in emerging market and developing economies in the mid-1990s. By 2000, global inflation had stabilized at historically low levels. Lower inflation has been accompanied by reduced inflation volatility, especially in advanced economies. This improvement in inflation outcomes has stemmed in large part from structural economic changes, including improved monetary and fiscal policy frameworks as well as international trade and financial liberalization. Lower and more stable inflation has often been associated with better growth and development outcomes, partly by reducing uncertainty, fostering a more efficient allocation of resources, and helping preserve financial stability.
An Investigation of the Informational Role of Short Interest in the Nasdsaq Market

This paper examines the informational role of short interest in the Nasdaq market. Using the population of monthly short interest data over the period of June 1988 through December 1994 we find that firms with high short interest experience significant negative abnormal returns ranging from -0.76% to -1.13% per month during the period over which they are heavily shorted. In contrast to results in Aitken et al. (1998) that show that information in short interest is incorporated quickly into prices for Australian stocks, we find that information in short interest is incorporated gradually into prices for Nasdaq stocks. The negative excess returns are increasing in the level of short interest indicating that a higher level of short interest is a stronger signal. Consistent with short interest being a bearish signal, we find that the heavily shorted firms get delisted with a higher frequency relative to their size and industry matched control firms.
Predicting the risk of multiple endocrine neoplasia type 1 for patients with commonly occurring endocrine tumors.

OBJECTIVE Endocrine diseases that can be part of the rare inheritable syndrome multiple endocrine neoplasia type 1 (MEN1) commonly occur in the general population. Patients at risk for MEN1, and consequently their families, must be identified to prevent morbidity through periodic screening for the detection and treatment of manifestations in an early stage. The aim of the study was to develop a model for predicting MEN1 in individual patients with sporadically occurring endocrine tumors. DESIGN Cross-sectional study. METHODS In a nationwide study in The Netherlands, patients with sporadically occurring endocrine tumors in whom the referring physician suspected the MEN1 syndrome were identified between 1998 and 2011 (n=365). Logistic regression analysis with internal validation using bootstrapping and external validation with a cohort from Sweden was used. RESULTS A MEN1 mutation was found in 15.9% of 365 patients. Recurrent primary hyperparathyroidism (pHPT; odds ratio (OR) 162.40); nonrecurrent pHPT (OR 25.78); pancreatic neuroendocrine tumors (pNETs) and duodenal NETs (OR 17.94); pituitary tumor (OR 4.71); NET of stomach, thymus, or bronchus (OR 25.84); positive family history of NET (OR 4.53); and age (OR 0.96) predicted MEN1. The c-statistic of the prediction model was 0.86 (95% confidence interval (95% CI) 0.81-0.90) in the derivation cohort and 0.77 (95% CI 0.66-0.88) in the validation cohort. CONCLUSION With the prediction model, the risk of MEN1 can be calculated in patients suspected for MEN1 with sporadically occurring endocrine tumors.
Technology heterogeneity in European industries' energy efficiency performance. The role of climate, greenhouse gases, path dependence and energy mix.

Assessment of industrial-level energy efficiency development is a critical research topic that has infiltrated in the global battle against climate change. A balanced panel of fourteen European industries from twenty-four countries for the period 1995-2011 is introduced into a metafrontier framework. Reflecting the divergent views on the importance of desirable and undesirable outcomes in the pursuit of energy efficiency, the proposed approach estimate industrial performance by prioritizing either economic or environmental criterion incorporating technological heterogeneity. It is found that small-scale economies exhibit persistent high energy efficiency scores. Regarding energy efficiency determinants, path dependence phenomena have a strong presence, climate characteristics occurs, while energy mix displays linear but also non-linear relationships. Finally, regardless of the method employed, there is a strong evidence of conditional and unconditional convergence.
Task Engagement and Attentional Resources

Objective: Two studies tested multivariate models of relationships between subjective task engagement and vigilance. The second study included a stress factor (cold infection). Modeling tested relationships between latent factors for task engagement and vigilance, and the role of engagement in mediating effects of cold infection. Background: Raja Parasuraman’s research on vigilance identified several key issues, including the roles of task factors, arousal processes, and individual differences, within the framework of resource theory. Task engagement is positively correlated with performance on various attentional tasks and may serve as a marker for resource availability. Method: In the first study, 229 participants performed simultaneous and successive vigilance tasks. In the second study, 204 participants performed a vigilance task and a variable-foreperiod simple reaction-time task on two separate days. On the second day, 96 participants performed while infected with a naturally occurring common cold. Task engagement was assessed in both studies. Results: In both studies, vigilance decrement in hit rate was observed, and task performance led to loss of task engagement. Cold infection also depressed both vigilance and engagement. Fitting structural equation models indicated that simultaneous and successive tasks should be represented by separate latent factors (Study 1), and task engagement fully mediated the impact of cold infection on vigilance but not reaction time (Study 2). Conclusions: Modeling individual differences in task engagement elucidates the role of resources in vigilance and underscores the relevance of Parasuraman’s vision of the field. Application: Assessment of task engagement may support diagnostic monitoring of operators performing tasks requiring vigilance.
Troponin T level as an exclusion criterion for stem cell transplantation in light-chain amyloidosis

The efficacy of stem cell transplantation in amyloidosis largely is determined by treatment-related mortality rates (range, 11 – 25%). Appropriate patient selection is essential to avoid this high mortality rate. Among 271 patients undergoing stem cell transplantation, troponin T was a powerful predictor of treatment-related mortality. Patients with troponin T levels of 0.06 µg/L or higher had a day-100 all-cause mortality rate of 28%. Patients with troponin T levels less than 0.06 µg/L had a day-100 all-cause mortality rate of 7% (P < 0.001). Troponin T levels should be measured in all patients before transplantation. Those with troponin T levels exceeding 0.06 µg/L should be considered for less toxic therapies until the clinically optimal use of stem cell transplantation is better defined by randomized clinical trials.
Mechanism and Immediate Outcome of Significant Mitral Regurgitation Following Balloon Mitral Valvuloplasty with JOMIVA Balloon.

INTRODUCTION Balloon Mitral Valvuloplasty (BMV) with inoue balloon is the most common technique being followed worldwide. Over the wire BMV is a modified technique with Joseph Mitral Valvuloplasty (JOMIVA) balloon and is being followed in certain centres. We hypothesized that, the incidence and mechanism of Mitral Regurgitation (MR) is likely to be different from that of inoue balloon. AIM To assess the mechanism and immediate clinical outcome of significant MR following BMV with JOMIVA balloon retrospectively. MATERIALS AND METHODS We retrospectively analyzed the outcome of 48 patients who developed moderate to severe MR out of 249 patients who underwent BMV in our institute. We analyzed the echocardiographic and clinical parameters of these patients. RESULTS Nineteen (7.6%) patients developed severe MR and 29 (11.2%) patients developed moderate MR. Commisural separation resulting in MR was the most common cause which was contributing to 73.6 % and 85.7% of patients with moderate and severe MR respectively. Leaflet tear was the second most common cause which contributed to 15.7% and 14.2% of patients with severe and moderate MR respectively. Chordal rupture contributed to 10.5% of patients with severe MR. Six (31.6%) patients with severe MR developed worsening breathlessness among them one had to be referred for mitral valve replacement during index hospitalization and the rest could be managed medically. Patients with moderate MR remained asymptomatic and stable. CONCLUSION Severe MR following JOMIVA BMV results most commonly due to wide separation of commisures. JOMIVA balloon is less likely to cause damage to subvalvular structures than inoue balloon. Most patients who develop severe MR will not require emergency mitral valve replacement. Moderate MR is well tolerated clinically.
Sex differences in nonhuman primate behavioral development

Sex differences in behavior and developmental trajectories in human children are of great interest to researchers in a variety of fields, and a persistent topic of discussion and debate is the relative contribution of biological vs. social influences to such differences. Given the potentially large effects of cultural and social influences on human child development, nonhuman primates are important model species for investigating the biological and evolutionary roots of sex differences in human development. This Mini‐Review briefly summarizes the existing literature on sex‐biased behavior toward infant nonhuman primates by mothers and other social partners, followed by a review of findings on sex differences (or lack thereof) in primate behavioral development from a variety of species in wild and naturalistic settings. These include differences in physical and social development, including play, grooming, and object manipulation patterns, as well as nursing and the development of foraging behavior. The Mini‐Review concludes by providing potential avenues for future research. © 2016 Wiley Periodicals, Inc.
l‐Arginine supplementation or arginase inhibition augments reflex cutaneous vasodilatation in aged human skin

Full expression of reflex cutaneous vasodilatation is dependent on nitric oxide (NO) and vasodilatation is attenuated in healthy older humans. NO bioavailability in aged skin may be decreased by an age‐related upregulation of arginase, which reciprocally regulates the NO‐synthase (NOS) substrate l‐arginine (l‐Arg). We hypothesized that increased arginase activity contributes to attenuated vasodilatation in aged skin by limiting l‐Arg for NOS‐mediated NO synthesis. Five microdialysis fibres were placed in forearm skin of 10 young (Y, 23 ± 1 years) and 9 older (O, 68 ± 1 years) human subjects, serving as control (C, Ringer solution), NOS‐inhibited (10.0 mmNG‐nitro‐l‐arginine), arginase‐inhibited (5.0 mm (S)‐(2‐boronoethyl)‐l‐cysteine + 5.0 mmNω‐hydroxy‐nor‐l‐arginine), l‐arg supplemented (l‐Arg; 10.0 mml‐arginine) and combined arginase‐inhibited +l‐Arg sites. After 20 min thermoneutral baseline, cutaneous vasodilatation was induced by passive whole‐body heating to increase oral temperature (Tor) by 1.0°C. Red blood cell flux was measured by laser‐Doppler flowmetry over each microdialysis site. Cutaneous vascular conductance was calculated (CVC = flux/mean arterial pressure) and normalized to maximal CVC (CVCmax, 28.0 mm sodium nitroprusside + local heating to 43°C). Cutaneous vasodilatation during heating was attenuated in O (Y, 42 ± 1, versus O, 30 ± 1%CVCmax, P < 0.001) at control sites. NOS inhibition decreased vasodilatation in both age groups compared to C (Y, 22 ± 2; O, 18 ± 2%CVCmax; P < 0.001). Arginase inhibition, l‐Arg supplementation, and arginase inhibition +l‐Arg supplementation augmented vasodilatation in O (arginase‐inhibited, 46 ± 4; l‐Arg, 44 ± 4; arginase‐inhibited +l‐arg, 46 ± 5%CVCmax; P < 0.001 versus C) but not in Y (arginase‐inhibited, 46 ± 4; l‐Arg, 38 ± 4; arginase‐inhibited +l‐Arg, 44 ± 4%CVCmax; P > 0.05 versus C). Increasing l‐Arg for NO synthesis by either arginase inhibition or direct l‐Arg supplementation restores the age‐related deficit in reflex cutaneous vasodilatation.
BRCA1 Augments Transcription by the NF-κB Transcription Factor by Binding to the Rel Domain of the p65/RelA Subunit*

BRCA1 is a tumor suppressor gene mutated in cases of hereditary breast and ovarian cancer. BRCA1 protein is involved in apoptosis and growth/tumor suppression. In this study, we present evidence that p65/RelA, one of the two subunits of the transcription factor NF-κB, binds to the BRCA1 protein. Treatment of 293T cells with the cytokine tumor necrosis factor-α induces an interaction between endogenous p65/RelA and BRCA1. GST-protein affinity assay experiments reveal that the Rel homology domain of the p65/RelA subunit of NF-κB interacts with multiple sites within the N-terminal region of BRCA1. Transient transfection of BRCA1 significantly enhances the ability of the tumor necrosis factor-α or interleukin-1β to activate transcription from the promoters of NF-κB target genes. Mutation of the NF-κB-binding sites in the NF-κB reporter blocks the effect of BRCA1 on transcription. Also the ability of BRCA1 to activate NF-κB target genes is inhibited by a super-stable inhibitor of NF-κB and by the chemical inhibitor SN-50. These data indicate that BRCA1 acts as a co-activator with NF-κB. In addition, we show that cells infected with an adenovirus expressing BRCA1 up-regulate the endogenous expression of NF-κB target genes Fas and interferon-β. Together, this information suggests that BRCA1 may play a role in cell life-death decisions following cell stress by modulation of the activity of NF-κB.
Comparison of association methods for dense marker data

While data sets based on dense genome scans are becoming increasingly common, there are many theoretical questions that remain unanswered. How can a large number of markers in high linkage disequilibrium (LD) and rare disease variants be simulated efficiently? How should markers in high LD be analyzed: individually or jointly? Are there fast and simple methods to adjust for correlation of tests? What is the power penalty for conservative Bonferroni adjustments? Assuming that association scans are adequately powered, we attempt to answer these questions. Performance of single‐point and multipoint tests, and their hybrids, is investigated using two simulation designs. The first simulation design uses theoretically derived LD patterns. The second design uses LD patterns based on real data. For the theoretical simulations we used polychoric correlation as a measure of LD to facilitate simulation of markers in LD and rare disease variants. Based on the simulation results of the two studies, we conclude that statistical tests assuming only additive genotype effects (i.e. Armitage and especially multipoint T2) should be used cautiously due to their suboptimal power in certain settings. A false discovery rate (FDR)‐adjusted combination of tests for additive, dominant and recessive effects had close to optimal power. However, the common genotypic χ2 test performed adequately and could be used in lieu of the FDR combination. While some hybrid methods yield (sometimes spectacularly) higher power they are computationally intensive. We also propose an “exact” method to adjust for multiple testing, which yields nominally higher power than the Bonferroni correction. Genet. Epidemiol. 2008. © 2008 Wiley‐Liss, Inc.
Fibre type-dependent response of broiler muscles to dietary antioxidant supplementation for oxidative stability enhancement

ABSTRACT The influence of dietary antioxidants and quality of oil on the oxidative and physico-chemical properties of chicken broiler breast and thigh meat stored was studied in either an oxygen-enriched (HiOx: 80% O2/20% CO2) or an air-permeable polyvinylchloride (PVC) packaging system during retail display at 2–4°C for up to 14 and 7 d, respectively. Broilers were fed on a diet with either a low-oxidised (peroxide value (POV) 23 meq O2/kg) or a high-oxidised (POV 121 meq O2/kg) oil, supplemented with or without an algae/selenium-based antioxidant with organic minerals, for 42 d. Lipid and protein oxidation, myofibrillar protein profile and purge loss were analysed. In both packaging systems, lipid oxidation (thiobarbituric acid-reactive substances [TBARS]) was inhibited by up to 65% and 57% in chicken breast and thigh, respectively, with an antioxidant-supplemented diet compared to those without. In both breast and thigh samples, protein sulfhydryls and water-holding capacity (purge loss) were better protected by the antioxidant dietary treatment, regardless of oil quality. Thigh muscles had up to sevenfold greater TBARS formation and more myosin heavy chain losses compared to breast samples. Antioxidant supplementation was more protective against lipid oxidation and water-holding capacity in the group fed on high-oxidised oil compared to those fed on low-oxidised oil. The results suggest that dietary antioxidants can minimise the negative impact of oxidised oil on broiler meat quality, and this protection was more pronounced for thigh than breast muscle, indicating inherent variations between muscle fibre types.
A Framework of Value Creation from Business Intelligence and Analytics in Competitive Sports

Over the last 10 years, Business Intelligence and Analytics (BI&A) has become a topic of great interest for Information Systems (IS) researchers and practitioners. BI&A initiatives have generated benefits in several organizations across various industries including banking, insurance, entertainment, retail, telecommunications, manufacturing, and more. A relatively new yet insightful domain of application for BI&A is competitive sports, where elite sports organizations, teams and athletes attempt to leverage the use of available data and technology to enhance their performance at many levels. While the use of BI&A tools in competitive sports have recently enjoyed sparks of popularity, academic research remains at a very early stage. In this paper, we provide a conceptual framework of value creation from BI&A use in competitive sports. Based on previous work on the business value of IT and IT-enabled competitive advantage, the framework underlines the multi-level nature of value creation for BI&A in competitive sports, and identifies a set of contextual contingencies that will affect the creation of value at each level of analysis. Finally, because research in BI&A use in competitive sports is still emerging, we identify a set of avenues for future research that, in combination with our proposed framework, will stimulate future studies in sports analytics.
Analyzing Electronic Word of Mouth Intention for Shopping Websites: A Means-End Chain Approach

Abstract Using a means-end chain (MEC) approach, this article proposes a comprehensive and integrative conceptual model of the antecedents of electronic word of mouth (eWOM) intention. It examines the effects of website attributes on eWOM intention, a topic that has not been explored in its relation to these attributes. Hypotheses are tested using partial least squares (PLS) modeling of data from 290 online customers in Taiwan. Attitudes toward websites and brand attitudes are found to mediate the link between website attributes and eWOM intention. The moderating effects of website trustworthiness and gender are found to influence the relationship between website attributes and consumer attitudes. This study contributes to the knowledge of the effects of website design that encourage consumers to provide positive eWOM when purchasing clothes via a website and provides some practical suggestions for online retailers.
Family wars : stories and insights from famous family business feuds

Chapter - 01: Family wars Chapter - 02: The ideas: The roots offamily warfare Chapter - 03: Brothers at arms Chapter - 04: Fighting for the crown Chapter - 05: The house that hubris built Chapter - 06: Heads in the sand - the insularity trap Chapter - 07: Schism - the house divided Chapter - 08: Un-civil war Chapter - 09: The lessons - the price of war and the prize of peace
Misallocation and Credit Market Constraints: The Role of Long-Term Financing

We measure aggregate productivity loss due to credit market constraints in a model with endogenous borrowing constraints, long-duration bonds, and costly equity payouts. Due to long-duration bonds, the model generates a realistic distribution of credit spreads. We structurally estimate our model using firm-level data on credit spreads from Thomson Reuters Bond Security Data and balance sheet data from Compustat. Credit market constraints increase aggregate productivity by 0.4% through their effect on the credit spread distribution. However, credit market constraints also interact with costly equity payouts, resulting in an overall productivity loss equal to 1.6%.
Spectrum of Hemoglobinopathies Among the Primitive Tribes

We evaluated the spectrum of hemoglobinopathies among the primitive tribal groups from 4 states in India. A total of 15 200 individuals from 14 primitive tribal groups were studied by automated high-performance liquid chromatography. The hemoglobin S (HbS) allele frequency varied from 0.011 to 0.120 and the β-thalassemia allele frequency from 0.005 to 0.024. It is interesting to note that a very high HbS allele frequency was observed among the Dravidian (0.060-0.120) and Indo-European (0.060-0.076) as compared with Austro-Asiatic (0.011-0.022) speaking tribal groups. Although statistical analysis of the data did not show any ethnic differences within the states, regional differences were observed between the states for both HbS and β-thalassemia traits. HbS was found to be the most common hemoglobinopathy followed by β-thalassemia. A health plan for identifying sickle-cell homozygotes in the neonatal period with proper medical intervention is desirable.