Miracle-dz/UniFAR-FTUs huggingface dataset:
The Role of Spinal Neurokinin‐2 Receptors in the Processing of Nociceptive Information from the Joint and in the Generation and Maintenance of Inflammation‐evoked Hyperexcitability of Dorsal Horn Neurons in the Rat

In spinal cord neurons in anesthetized rats, the role of neurokinin A and neurokinin‐2 receptors in the processing of nociceptive information from the knee joint was studied. The specific non‐peptide antagonist at the neurokinin‐2 receptor, SR48968, its inactive R‐enantiomer, SR48965, neurokinin A, substance P and (R, S)‐α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionic acid (AMPA), were administered ionophoretically close to neurons with input from the knee joint. SR48968 reduced the effects of exogenous neurokinin A, but not those of exogenous substance P and AMPA, indicating selective blockade of neurokinin‐2 receptors. In most neurons with input from the normal knee joint, SR48968 reduced dose‐dependently the responses to noxious pressure applied to the knee, and in ˜50% of the neurons the responses to innocuous pressure. The administration of SR48968 during the induction of an experimental joint inflammation markedly attenuated the development of inflammation‐evoked hyperexcitability. In hyperexcitable neurons with input from the inflamed joint, SR48968 reduced the responses to noxious and innocuous pressure. The relative reduction of the responses was more pronounced than in neurons with input from the normal joint. None of the effects of SR48968 was mimicked by SR48965. These data show that neurokinin‐2 receptors are involved in the spinal processing of nociceptive information from the normal joint. Furthermore, neurokinin‐2 receptors must be coactivated at an early stage of inflammation, to allow the generation of hyperexcitability. Finally, neurokinin‐2 receptors are involved in the maintenance of hyperexcitability during inflammation. In summary, spinal neurokinin‐2 receptors are important in the generation of pain in the normal and inflamed joint.
Effect of seminal plasma and egg yolk concentration on freezability of goat semen

The objective of this study was to evaluate the effects of egg yolk and seminal plasma on the viability of cryopreserved goat semen. To this end, four fertile Saanen bucks, aged between 10 months and 1 year, and weighing 18 to 25 kg, were used. Semen was collected from each buck by the artificial vagina method at the end of breeding season (June-July). The extender used was the yolk citrate, which was split into two equal aliquots: 5% egg yolk (2.5 mL egg yolk: 47.5 mL citrate solution) were added to one of the samples and 10% egg yolk (5.0 mL egg yolk: 45.0 mL citrate solution) were added to another. The sperm motility and vigor after thawing and post thermal resistance test (TRT) were evaluated and the data were subjected to analysis of variance and means were compared by the F test at 5.0% probability. The observed values for motility and vigor after thawing and post thermal resistance test (TRT), fast and slow, according to the presence of seminal plasma and egg yolk percentage were: 5% egg yolk with plasma (25.0% and 3.3; 1.60% and 0.7; 12.36% and 1.6, respectively); 5% egg yolk without plasma (23.61% and 3.1; 1.25% and 0.2; 9.93% and 1.3, respectively); 10% egg yolk with plasma (30.8% and 3.3; 4.4% and 1.9; 19.5% and 2.7, respectively); and 10% egg yolk without plasma (13.4% and 2.5; 4.1% and 0.5; 17.0% and 1.0, respectively). There were significant differences between the analyzed data in relation to semen with or without plasma at different percentages of egg yolk, and the group that presented the best results was 10% egg yolk citrate in extender with plasma. The presence of seminal plasma and higher concentration of egg yolk in extender provide a higher viability of cryopreserved goat semen.
High-Resolution Measurements of Rotons in 4He.

We have measured the temperature dependence of the roton line shape (energy and width) using neutron backscattering. An energy resolution of less than 1 μeV was obtained, allowing a determination of the roton linewidth down toT=0.8 K. These results constitute a significant improvement on the previous best determination and extend the measured range of roton linewidth and energy shift by an order of magnitude. The temperature dependence of the measured linewidths is found to be in excellent agreement with calculations based on the 4-phonon decay process. The roton energy, however, is found to vary significantly more slowly with temperature than expected from the same theory. The origin of this discrepancy is not yet understood.
Effectiveness of a diabetes mellitus pictorial diary handbook program for middle-aged and elderly type 2 diabetes mellitus patients: a quasi-experimental study at Taladnoi Primary Care Unit, Saraburi, Thailand

Aim The research question is “How does a diabetes mellitus (DM) pictorial diary handbook (PDHB) affect the knowledge, practice, and HbA1c among patients with DM type 2? ” The aim of this study was to evaluate the effect of a PDHB program among middle-aged and elderly patients with DM type 2 in primary care units in Thailand. Patients and methods A quasi-experimental study design was applied. DM type 2 patients were recruited in the PDHB program by a simple random sampling method. The 3-month program consisted of a weekly health education structured for ~20 minutes, a 15-minute group activity training, a 10-minute individual record of participants’ knowledge and practice regarding diet control, exercise, oral hypoglycemic drug taking, diet, self-care, alcohol consumption, smoking, weight management, and HbA1c, and a 15- to 30-minute home visit as well as the PDHB for recording self-care behavior daily. The control group received only the usual diabetes care. The primary expected outcomes were changes in HbA1c from the baseline data to 3 months after the program compared between the intervention and control groups. The secondary expected outcomes were compared within the intervention group. The third expected outcomes were changes in the mean score of knowledge and practice from baseline to 3 months after the program within and between the intervention and control groups. Results Compared with the baseline data, there was no significant difference in HbA1c, knowledge, and practice mean score between the intervention and control groups. However, there was a significant difference in HbA1c, knowledge, and practice mean score in the intervention group after they received a 3-month PDHB program and within the intervention group (p-value =0.00). Conclusion The PDHB program was effective in lowering HbA1c while also improving the mean score of knowledge and practice among elderly patients with DM type 2. However, larger and longer trial studies will be needed to evaluate the sustainability of this program.
Description and genetic characterization of a new Contracaecum larval type (Nematoda: Anisakidae) from Australia

Abstract Nematode parasites belonging to the genus Contracaecum are economically important parasites with zoonotic significance. Adult Contracaecum spp. are found in the stomach of marine mammals or piscivorous birds, and larval stages infect a wide range of invertebrates and fish species. Human infection with Contracaecum larvae has been reported in Australia and other countries after the consumption of infected fish. Although the genus Contracaecum comprises numerous species, thus far only four Contracaecum larval types have been specifically identified, therefore their life cycle and biology are not yet fully understood. In this study, a new Contracaecum larva (type IV), found in the intestinal tissue of carp caught from Coonancoocabil Lagoon, New South Wales, Australia, is described and characterized genetically. It was identified as Contracaecum bancrofti, a unique Australian species reported previously from the Australian pelican in Northern Territory, New South Wales, Victoria and South Australia. This study highlights the role of migratory birds and introduced fish species, such as carp, in distributing zoonotic pathogens not only across the continent but also from marine to freshwater systems. Coonancoocabil Lagoon is located in the Murrumbidgee Valley National Park, a highly managed conservation area with native fish in wetlands located in close proximity to several fish farms and hatcheries. Infection of a highly resilient invasive fish species, such as carp, with a zoonotic parasite of low host specificity, such as Contracaecum larvae, should be alarming for aquaculture and environmental authorities.
On the relational dynamics of caring: a psychotherapeutic approach to emotional and power dimensions of women's care work

Care is double-edged and paradoxical, inspiring a vast range of strong feelings in both care-givers and care-recipients. This article draws on ideas about psychotherapeutic relationships to offer a theorisation of the complex emotional and power dynamics and imaginative geographies of care. Examining the humanistic approach developed by Carl Rogers as well as the psychoanalytic tradition, I advance an interpretation of psychotherapeutic practices that foregrounds the fundamental importance of the emotional and power-inflected relationship between practitioners and those with whom they work. I show how different traditions offer conceptualisations of the shape of therapeutic relationships that are highly relevant to consideration of the emotional and power dynamics of giving and receiving care. Against this background I discuss current debates about care, emotions and power, drawing especially on feminist and disability perspectives and arguing that psychotherapeutic approaches offer a powerful lens through which to understand the emotional and power dynamics of caring relationships. I conclude by emphasising how this theorisation helps to illuminate ubiquitous features of women's care work.
Association Between Lipoprotein(a) and Insulin-Like Growth Factor I During Puberty and the Relationship to Microalbuminuria in Children and Adolescents With IDDM

OBJECTIVE To study pubertal changes in serum lipoprotein(a) [Lp(a)] and insulin-like growth factor I (IGF-I) in insulin-dependent diabetes mellitus (IDDM) and the relationship to microalbuminuria. RESEARCH DESIGN AND METHODS Seventy-nine children and adolescents (59 with normoalbuminuria, 20 with microalbuminuria) with ≥ 5 years of IDDM were investigated together with 54 healthy control subjects in a cross-sectional study. Fasting serum Lp(a); apolipoprotein (apo) A-1 and B; total, low-density lipoprotein (LDL), and high-density lipoprotein cholesterol; triglycerides; and IGF-I were analyzed as were HbA1c and overnight albumin excretion rate (AER). Pubertal development was assessed by Tanner staging. RESULTS Lp(a), apoB, triglycerides, and total and LDL cholesterol were higher (P < 0.001) and apoA-1 was lower (P = 0.03) in normoalbuminuric IDDM patients than in healthy control subjects. Lp(a) was increased during puberty (stages 2–4) in IDDM patients but not in healthy subjects, whereas IGF-I was significantly increased during puberty in healthy control subjects only. In IDDM patients Lp(a) correlated to insulin dose, total cholesterol, and LDL cholesterol, but not to IGF-I, HbA1c, systolic and diastolic blood pressure, diabetes duration, age, or sex. In multiple regression analysis with Lp(a) as the dependent variable, puberty was the only significant contributor to the regression (r2 = 0.33, P = 0.008). Microalbuminuria was seen only in the pubertal stage 4–5. Lp(a) tended to be higher (P = 0.06) as did apoB, whereas IGF-I was lower (P < 0.001) in this group than in normoalbuminuric patients of the same pubertal stages. In multivariate analysis, with log AER as the dependent variable, apoB/apoA-1, systolic blood pressure, age, and IGF-I but not Lp(a) added to the regression (r2 = 0.47, P < 0.0001). CONCLUSIONS Lp(a) is elevated during puberty in normoalbuminuric subjects with IDDM, independent of metabolic control and IGF-I. Lp(a) tends to be further increased in microalbuminuria but does not seem to be a contributing determinant of log AER whereas low IGF-I does. Prospective studies are required to establish the temporal relationship between increased Lp(a) and microalbuminuria in children and adolescents with IDDM.
Modeling the distribution of insulin in pancreas

Maintenance of adequate pancreatic β-cell mass, via suppression of programmed cell death and/or sustained proliferation is critical for the prevention or delay of diabetes mellitus. It is well established that insulin potently activates mitogenic and anti-apoptotic signaling cascades in cultured β-cells. Furthermore, loss of β-cell insulin receptors is sufficient to induced type 2 diabetes in animal models. However, it remains unclear whether the in vitro effect in human islets and the in vivo effects in mice can be applied to human physiology. The major obstacle to a complete understanding of the effects of insulin’s feedback in human pancreas is the absence of technology to measure the concentrations of insulin inside of pancreas. To contextualize recent in vitro data, it is essential to know the local concentration and distribution of insulin in pancreas. To this end, we formulate a novel mathematical model to investigate the distribution and concentration of insulin within pancreas using existing physiological data and islet imaging data. Our studies reveal that insulin concentration along pancreas, related to glucose level, increases nearly linearly in the fashion of increasing quicker in tail area but slower in head area. We also showed that the factor of small diffusion with blood is negligible since the convection of blood flux dominates. To the best of our knowledge, our model is the first attempt to estimate the glucose and insulin C. Hu · J. Li ( ) Department of Mathematics, University of Louisville, Louisville KY 40292, USA. JL is supported in part by NIH Grant R01-DE019243, P30-ES01443 and DOE Grant DEEM000197. E-mail: jiaxu.li@Louisville.edu J.D. Johnson Department of Cellular and Ohysiological Sciences and Department of Surgery, University of British Columbia, Vancouver, BC, Canada, V6T 1Z3. JJ is supported by the Canadian Institutes for Health Research, the Juvenile Diabetes Research Foundation, the Michael Smith Foundation for Health Research, and the Canadian Diabetes Association. 2 Changbing Hu et al. distributions in pancreas. Our model is simple, robust and thus can be easily adopted to study more sophistic cases.
The Effect of Social Support and Acculturation on Postpartum Depression in Mexican American Women

Postpartum depression was studied in 66 multiparous Mexican American women using a prospective longitudinal design. Interviews were conducted at 34 to 36 weeks prenatally and 4 to 6 weeks postpartum. Women expressing prenatal depression were more likely to continue to experience depression postpartum. Other predictors included a high need for postpartum support, specific support network characteristics, acculturation, and poor quality relationships within the family. It is important for the health care provider to assess the presence of depressive symptoms and available social support during the prenatal period and work with Mexican American mothers to increase support and secure help in dealing with daily life stressors.
Mortalidade de motociclistas em acidentes de trânsito: tendência temporal entre 1997 e 2012/Motorcyclist mortality in traffic accidents: temporal trend between 1997 and 2012

O objetivo deste estudo foi o de descrever as caracteristicas sociodemograficas dos motociclistas mortos em acidentes de trânsito e analisar a tendencia temporal da mortalidade no periodo de 1997 a 2012. Estudo epidemiologico da mortalidade de 320 motociclistas, residentes em Maringa, Parana. Os dados foram extraidos do Sistema de Informacao sobre Mortalidade do Departamento de Informatica do Sistema Unico de Saude (Datasus). A analise de tendencia foi realizada a partir do ajuste de um modelo de regressao de Poisson para series temporais. A maioria das vitimas (85,00%) era do sexo masculino, na faixa etaria entre 20 e 39 anos (62,19%), branca (78,75%), com escolaridade entre oito e 11 anos de estudo (38,75%) e solteira (62,82%). Os obitos ocorreram com maior frequencia nos hospitais (53,13%) e no momento do acidente, e apenas 16,87% dos individuos estavam trabalhando. Houve predominio das colisoes com automovel/caminhonete (38,75%). Observou-se aumento progressivo de mortes de 8,2% ao ano (IC 95%: 7% - 9%). A partir do modelo estimado de tendencia, a media de obitos aumentou de 8,42, em 1997, para 34,5, em 2012. Conclui-se que esses eventos representam um grave problema de saude publica, aumentando em todo o mundo, em proporcoes significativas.
Proximal analysis of seagrass species from Laguna de Términos, Mexico

El presente trabajo consiste en la caracterizacion quimica nutrimental de tres especies de pastos marinos ( Thalassia testudinum Konig , Halodule wrightii Ascherson y Syringodium filiforme Kutzing) de la Laguna de Terminos, Campeche, Mexico, durante la temporada de lluvias de 2004 siguiendo los metodos de analisis descritos por la Asociacion Oficial de Quimicos Analiticos. Altos niveles de proteina (8.47-10.43%), de fibra cruda (15.70-19.43%), de ceniza (23.43-38.77%) de extracto libre de Nitrogeno (37.27-45.37%) asi como bajos niveles de lipidos (0.83-2.13%) fueron una caracteristica comun de las tres especies analizadas. Considerando la composicion quimica y los estandares de referencia de la Organizacion Mundial de la Salud, en particular el alto contenido de proteina (10.43%), de ceniza (23.43%), alto contenido de fibra (19.43%), de extracto libre de Nitrogeno (45.37%) y bajo nivel de lipidos (2.13%) medido para S. filiforme , sugiere su aplicacion como un buen suplemento alimenticio y fuente de nutrimentos para el humano. El uso de pastos marinos con alto contenido de proteinas para la produccion de alimentos para peces podria ser otra aplicacion de este recurso marino
Pediatric Kidney Transplantation Followed by De Novo Therapy With Everolimus, Low-Dose Cyclosporine A, and Steroid Elimination: 3-Year Data

Background. Acute rejections and infections continue to cause substantial problems for pediatric kidney transplant (KTX) patients because defining an immunosuppressive protocol capable of preventing both has been challenging. Previously, we initiated a prospective trial to evaluate an immunosuppressive regimen designed to achieve this goal. Herein, we present the results of the 3-year follow-up of this trial. Methods. After KTX, 20 children (median age 12 years, range 1–17 years) received basiliximab, cyclosporine A (CsA) (trough-level=C0 200–250 ng/mL), and prednisolone. Two weeks post-KTX, everolimus (1.6 mg/m2/day) treatment was started (C0 4–6 ng/mL), and the CsA dose was reduced by 50% (C0 75–100 ng/mL, after 6 months: C0 50–75 ng/mL). Prednisolone treatment was gradually withdrawn and was completely stopped at 9 months post-KTX. Results. There was no loss of follow-up and no graft or patient loss during the 3-year period. Indication biopsies showed no acute rejection (Banff ≥IA). One of the patients had signs of chronic humoral rejection. Mean glomerular filtration rate measured at 1 year and 3 years post-KTX was 71±25 and 61±27 mL/min/1.73 m2, respectively. In patients transitioned to adult care, mean glomerular filtration rate at 3 years was 49±13 mL/min/1.73 m2 (P<0.05). No cases of posttransplant lymphoproliferative disorder posttransplant lymphoproliferative disorder or polyoma nephropathy were diagnosed. After 3 years, 17 of 20 patients remained on the original immunosuppressive regimen. Conclusions. A treatment regimen consisting of de novo immunosuppression with basiliximab, CsA, and prednisolone, followed by treatment with everolimus and low-dose CsA combined with steroid withdrawal may be a promising therapy after pediatric KTX.
A 47,XX,+der(21)t(8;21)(q24.2;q21.1) karyotype in a patient with mild intellectual disability, cleft lip, hashimoto thyroiditis and hirsutism

Here,wepresent a patientwith an apparent trisomy21 (Fig. 1) and a mild phenotype. The patient, a 22-year-old woman, came to our observation becauseofmild intellectual disability. She is theonly childof healthy andunrelated parents; shewas born at 32weeks of gestation after an eventful pregnancy except for a threatened miscarriage during the first trimester of pregnancy; her mother was 21 and her father 25. Family history was unremarkable. Birth weight was 1,970 g (>50th centile corrected age), length 42 cm (50th centile corrected age) and head circumference 29 cm (50th centile corrected age). At birth she presented with respiratory distress and apneic crisis that did not require mechanical ventilation. She had a unilateral cleft lip, an angioma localized on the superior portion of the helix of the right ear, and a skeletal anomaly of the left thumb, which was surgically corrected. The parents did not keep anymedical record of the surgical operation, thus it is not possible to be more specific about this anomaly. Psychomotormilestones have been reported as mildly delayed. During infancy, she showed distinctive morphological features of the face: high forehead, depressed nasal bridge with triangular and bulbous nasal tip, thin eyebrows, long philtrum with thin upper lip vermilion (Fig. 2). Axillary and pubic hair had been present since 3 years of age and FSH levels were high at this age (7 mUI/ml), whereas, LH levels were normal. Menarche occurred at 10 years old and menstruation cycles were regular. At the age of 19, excessive growth of thick dark hair appeared on her body, mainly on the face, the chest, and the upper back. Repeated evaluation of gonadotropins and gonadal steroids levels was normal. Only testosterone levels were slightly above the normal range: total testosterone was 0.9 ng/ml (normal range 0.1–0.8 ng/ml) and free testosterone was 4.71 pg/ml (normal range 0.3–3.2 pg/ml). Brain MRI was normal. Ultrasound examination of the pelvis detected a micropolycystic left ovary. She developed chronic autoimmune thyroiditis with normal thyroid function. Her height was 161 cm, weight 95 kg, and BMI was 36.6 kg/m. Karyotype analysis revealed an apparent trisomy 21. Parental chromosome analysis detected a balanced translocation t(8;21) (q24.2;q21.1) in her mother. The derivative 21 was transmitted to the patientwith a segregation3:1 (Fig. 3). Thepatient’s karyotype was given as 47,XX,þder(21)t(8;21)(q24.2;q21.1). Array CGH
Scanning the business external environment for information: evidence from Greece

Introduccion. Este articulo examina la teoria de la exploracion (monitoreo) del entorno externo de empresas por informacion en el contexto de Grecia. Metodo. Se desarrollo una encuesta para explorar las relaciones entre el entorno general y laboral de empresas, la incertidumbre percibida, la estrategia de exploracion, y fuentes de informacion con respecto al tipo de entorno, tamano e industria. La investigacion se baso en una muestra de 144 organizaciones privadas que operan en el norte de Grecia. Analisis. Se analizaron los datos recogidos usando SPSS. Para probar las hipotesis desarrolladas se siguieron los procedimientos estadisticos de prueba de homogeneidad chi-cuadrada, ANOVA, prueba de Duncan de homogeneidad de medias, y la prueba-t de muestras relacionadas. Resultados. Los resultados muestran que la incertidumbre percibida de los factores del entorno general y laboral externo de empresas depende del tipo de entorno, el tamano de organizacion, e industria donde operan las organizaciones; las organizaciones adaptan su estrategia de exploracion a la complejidad del entrono; las fuentes personales de informacion parecen ser mas importantes que las fuentes impersonales; las fuentes externas de informacion son igualmente importantes que las fuentes internas; y los niveles mas altos de incertidumbre ambiental se asocian con los niveles mas altos de exploracion de las diversas fuentes. Conclusion. La exploracion del entorno externo de empresas de informacion esta influenciada por las caracteristicas de las mismas organizaciones y por las caracteristicas del entorno externo en el que operan. El estudio contribuye a la teoria de la exploracion ambiental y tiene importantes mensajes para los profesionales.