Miracle-dz/UniFAR-FTUs huggingface dataset:
Myoferlin plays a key role in VEGFA secretion and impacts tumor‐associated angiogenesis in human pancreas cancer

Pancreatic ductal adenocarcinoma is one of the most deadly forms of cancers with no satisfactory treatment to date. Recent studies have identified myoferlin, a ferlin family member, in human pancreas adenocarcinoma where its expression was associated to a bad prognosis. However, the function of myoferlin in pancreas adenocarcinoma has not been reported. In other cell types, myoferlin is involved in several key plasma membrane processes such as fusion, repair, endocytosis and tyrosine kinase receptor activity. In this study, we showed that myoferlin silencing in BxPC‐3 human pancreatic cancer cells resulted in the inhibition of cell proliferation in vitro and in a significant reduction of the tumor volume in chick chorioallantoic membrane assay. In addition to be smaller, the tumors formed by the myoferlin‐silenced cells showed a marked absence of functional blood vessels. We further demonstrated that this effect was due, at least in part, to an inhibition of VEGFA secretion by BxPC‐3 myoferlin‐silenced cells. Using immunofluorescence and electron microscopy, we linked the decreased VEGFA secretion to an impairment of VEGFA exocytosis. The clinical relevance of our results was further strengthened by a significant correlation between myoferlin expression in a series of human pancreatic malignant lesions and their angiogenic status evaluated by the determination of the blood vessel density.
Pharmacological Augmentation of NMDA Receptor Function for Treatment of Schizophrenia a

Acute low-dose administration of phencyclidine (1,l-phenylcyclohexylpiperidine; PCP) induces a schizophrenia-like psychotic state in nonpsychotic subjects. By contrast to amphetamine administration, PCP psychosis incorporates negative symptoms (withdrawal, negativism, autism) and cognitive dysfunction (impairment of abstract thinking, symbolic thinking, attention, and perception), as well as positive symptoms closely resembling those in schizophrenia. '-* Neuropsychological tests requiring sustained attention and paired-associate learning are most affected by low-dose PCP administration,' suggesting that, as in schi~ophrenia,~J" prefrontal and temporohippocampal processing may be most severely disturbed by PCP. Furthermore, subjects with Schizophrenia are uniquely sensitive to the psychotomimetic effects of PCP. A single dose of PCP administered to recompensated schizophrenic subjects recreated the presenting symptomatology for days3 to ~ e e k s ~ , ~ without inducing symptoms and signs atypical of schizophrenia; by contrast, psychotomimetic PCP effects in normal subjects typically resolve within four to six hours, although a minority of subjects-approximately 20%-may develop symptoms for a longer period of time. Subjects predisposed to schizophrenia based upon premorbid symptoms or family history appear to be at increased risk for developing prolonged symptoms.1i Nonschizophrenic patients with PCP psychosis are difficult to differentiate from acute schizophrenics on the basis of presenting symptomatology alone.llJz Administration of PCP to monkeys can simulate the abnormalities in event-related potentials seen in schizophrenic ~ubjec ts . '~J~ Finally, patterns of brain metabolism determined by positron emission tomography in nonschizophrenic chronic PCP users have been reported to be abnormal and to resemble patterns seen in chronic schizophrenic^. '^ At serum concentrations (10-100 nM) calculated16 to result from the selectively psychotomimetic human dose of 0.1 mg/kg of PCP, the only significant central nervous system (CNS) target site is the PCP receptor, which has a nanomolar affinity for PCP and binds PCP-like drugs with affinities paralleling their potencies in
PART-PRODUCTS OF S-RESTRICTED INTEGER

If S is a cofinite set of positive integers, an “S-restricted composition of n” is a sequence of elements of S, denoted ~λ = (λ1, λ2, . . . ), whose sum is n. For uniform random S-restricted compositions, the random variable B(~λ) = ∏ i λi is asymptotically lognormal. (A precise statement of the theorem includes an error term to bound the rate of convergence.) The proof is based upon a combinatorial technique for decomposing a composition into a sequence of smaller compositions.
[Prevalence of microscopic colitis in patients with irritable bowel syndrome with diarrhea predominance].

BACKGROUND Microscopic colitis (MC) and irritable bowel syndrome with diarrhea (IBSD) have a similar clinical and endoscopic presentation. The prevalence of MC in Mexican patients with IBS-D is unknown. OBJECTIVES To find out the prevalence of MC in patients with IBS-D and compare it with the one observed in patients with IBS with constipation (IBS-C). METHODS All patients with IBS (Rome III) seen consecutively from January 2008 to August 2010 were included. Those with organic disease, alarm signs, mixed IBS or unsubtyped- IBS (Rome III) were excluded. Colonoscopy with biopsies was performed in all patients that were examined by two pathologists who did not know the clinical characteristics of the subjects. MC was defined according with the universally accepted histological criteria. RESULTS 155 patients with IBS-D and 145 with IBS-C were studied. Both groups were matched from the standpoint of age, gender ratio and time course of disease. MC was detected in 28 patients with IBS-D and in one with IBS-C (18% vs. 0.7%, p <0.0001). Fifteen patients with lymphocytic colitis and 14 with collagenous colitis were detected. The endoscopic appearance of the colon mucosa was normal in 20 of the 29 patients with MC (69%). CONCLUSIONS The prevalence of MC in patients with IBS-D was 18%, significantly higher than the one observed in patients with IBS-C. Colonic mucosa had a normal appearance in most of the patients with MC. Systematic biopsies are recommended in patients with IBS-D.
Phase I study of safety and pharmacokinetics of the anti-MUC16 antibody-drug conjugate DMUC5754A in patients with platinum-resistant ovarian cancer or unresectable pancreatic cancer.

BACKGROUND MUC16 is a tumor-specific antigen overexpressed in ovarian (OC) and pancreatic (PC) cancers. The antibody-drug conjugate (ADC), DMUC5754A, contains the humanized anti-MUC16 monoclonal antibody conjugated to the microtubule-disrupting agent, monomethyl auristatin E (MMAE). PATIENTS AND METHODS This phase I study evaluated safety, pharmacokinetics (PK), and pharmacodynamics of DMUC5754A given every 3 weeks (Q3W, 0.3-3.2 mg/kg) or weekly (Q1W, 0.8-1.6 mg/kg) to patients with advanced recurrent platinum-resistant OC or unresectable PC. Biomarker studies were also undertaken. RESULTS Patients (66 OC, 11 PC) were treated with DMUC5754A (54 Q3W, 23 Q1W). Common related adverse events (AEs) in >20% of patients (all grades) over all dose levels were fatigue, peripheral neuropathy, nausea, decreased appetite, vomiting, diarrhea, alopecia, and pyrexia in Q3W patents, and nausea, vomiting, anemia, fatigue, neutropenia, alopecia, decreased appetite, diarrhea, and hypomagnesemia in Q1W patients. Grade ≥3-related AE in ≥5% of patients included neutropenia (9%) and fatigue (7%) in Q3W patients, and neutropenia (17%), diarrhea (9%), and hyponatremia (9%) in Q1W patients. Plasma antibody-conjugated MMAE (acMMAE) and serum total antibody exhibited non-linear PK across tested doses. Minimal accumulation of acMMAE, total antibody, or unconjugated MMAE was observed. Confirmed responses (1 CR, 6 PRs) occurred in OC patients whose tumors were MUC16-positive by IHC (2+ or 3+). Two OC patients had unconfirmed PRs; six OC patients had stable disease lasting >6 months. For CA125, a cut-off of ≥70% reduction was more suitable for monitoring treatment response due to the binding and clearance of serum CA125 by MUC16 ADC. We identified circulating HE4 as a potential novel surrogate biomarker for monitoring treatment response of MUC16 ADC and other anti-MUC16 therapies in OC. CONCLUSIONS DMUC5754A has an acceptable safety profile and evidence of anti-tumor activity in patients with MUC16-expressing tumors. Objective responses were only observed in MUC16-high patients, although prospective validation is required. CLINICAL TRIAL NUMBER NCT01335958.
β‐Globin Gene Cluster Haplotypes Linked to the βS Gene in Western India

The present survey, which involves 70 sickle cell anemia patients from Gujarat and Maharashtra revealed a high prevalence of the typical Arab‐Indian haplotype (91.5 %). Six atypical haplotypes, including a Cameroon one were also found. Correlation of these various haplotypes with HbF expression was studied.
Regulation of sarcomere number in skeletal muscle: A comparison of hypotheses

Sarcomere lengths from 16 locations in the muscles of mastication were measured from pigs fixed in maximum excursion (wide jaw opening) and in postural position (near occlusion). These data, plus published data on sarcomere lengths in rabbit jaw muscles, were used to evaluate conflicting hypotheses about the factors which regulate serial sarcomere number in striated muscles. According to the most successful hypothesis, sarcomere number is adjusted so as to achieve an optimum sarcomere length when the muscle is experiencing a high level of tension. Most often, this occurs at jaw positions where the muscle is electrically active.
Intracerebral Hemorrhage

Introduction:Intracerebral hemorrhage (ICH) occurs from the rupture of small vessels into the brain parenchyma and accounts for approximately 10% of all strokes in the United States, and carries with it a significantly high morbidity and mortality. Summary:This article reviews the course and management of ICH. The most common chronic vascular diseases that lead to ICH are chronic hypertension and cerebral amyloid angiopathy. Additional factors that predispose to ICH include vascular malformations, chronic alcohol use, hypocholesterolemia, and use of anticoagulant medications. The understanding of mechanisms leading to ICH has advanced significantly, but questions regarding site predilection and timing of spontaneous hemorrhage still remain. Management in the acute setting is first focused on reducing hematoma expansion. Although no specific therapy has yet been proven effective, promising agents, particularly recombinant Factor VIIa, are on the horizon. Subsequent care is focused on controlling hemostasis, hemodynamics, and intracranial pressure in efforts to minimize secondary brain injury. Conclusion:The morbidity and mortality associated with ICH remain high despite recent advances in our understanding of the clinical course of ICH. Novel preventive and acute treatment therapies are needed and may be on the horizon.
Genetic variability, correlation and path analysis for yield and yield contributing characters in soybean (Glycine max L.).

The genetic variability studies carried out on 50 soybean genotypes indicated that the estimate of phenotypic coefficient of variation were greater than those of the genotypic coefficient of variation for all the traits studied. The close proximity between PCV & GCV values for most of the characters indicated less influence of environment on the expression of the characters under study. Considering heritability, most of the characters showed high values. High heritability coupled with high genetic advance as per cent of mean were recorded for biological yield plant-1, harvest index, number of seeds plant-1, seed yield plant-1 and number of pods plant-1 indicating the scope of improvement through direct selection. Correlation analysis revealed that number of pods node-1, number of seeds plant-1, biological yield plant-1, number of nodes plant-1 and harvest index were positively and significantly associated with seed yield plant-1. Path analysis revealed that number of pods node-1 had the high positive direct effect on seed yield plant-1 followed by number of nodes plant-1, number of seed yield plant-1, biological yield plant-1 and harvest index. Traits viz., number of pods plant-1, days to 50% flowering, days to maturity had negative direct effect on seed yield plant-1. Most of the other traits had indirect effect via number of branches plant-1, number of pods plant-1 and 100-seed weight. Hence, these characters should be given more weightage in selection programme of high yielding soybean genotypes.
Factors associated with geographic tongue and fissured tongue

Abstract Objectives: The primary objective of this study was to investigate the association of systemic diseases, use of medications, allergies and tobacco habits with geographic tongue (GT) and fissured tongue (FT) lesions. The secondary objectives were to evaluate the clinical characteristics of tongue lesions and to compare the overall results for referred and non-referred patients. Methodology: Non-referred patients with GT (GTgp; n = 130) and FT (FTgp; n = 62) were examined by general practitioners (gp) and compared to a control group without oral mucosal lesions (C; n = 1029). Referred patients with GT (GTs; n = 166) and FT (FTs; n = 15) were examined by oral medicine specialists (s) and compared to GTgp and FTgp. Statistical analyses were performed using unpaired t-test or Fisher’s exact test. A multiple logistic regression model was developed to control for age and gender as confounders. Results: Compared to the C group, GTgp patients used more anti-hypertensive medications and Swedish snus (p < 0.01). The GTgp group consisted of older males (p < 0.001) compared to C. Compared to the GTgp group, the GTs group was younger, more likely to have symptomatic lesions (p < 0.0001) and comprised of more females. Among the groups examined, FT patients had the highest mean age. Conclusion: This study identified an association between GT and anti-hypertensive medications, as well as the use of Swedish snus. It also found differences in the activities and symptoms of the lesions between referred patients and their counterparts who were seen in general dental practice; these parameters influenced the results when these conditions were taken into account.
Cardiac anomalies in a group of HIV-infected children in a pediatric hospital: an echocardiographic study in Yaounde, Cameroon.

BACKGROUND Cardiac manifestations associated with the HIV infection are known adversely prognosis in adults and children, even at the infraclinical stage. Although cardiac complications of HIV infection are well described in adults, there are few reports in the paediatric age group. We performed echocardiography on a group of HIV-infected children in order to describe the spectrum of the anomalies associated with the HIV infection. METHODS We carried out a cross-sectional descriptive study on a cohort of HIV-infected children followed-up in a children's out-patient clinic. All had a thorough clinical evaluation and transthoracic echocardiography with Doppler flux analysis. The data collected were analyzed with SPPS 18.0, IBM, Chicago. Statistical significance was set at P value <0.05. RESULTS One hundred children (52 males and 48 females) were studied. Their ages ranged from 1 to 15 years with a mean of 7 years. Forty four (44%) and 33 (33%) of the children were in World Health Organization (WHO) clinical stage III and IV respectively. Fifty seven (57%) did not have any significant immune depression. The mean age at diagnosis of HIV infection was 3 years. Ninety one percent of the participants were on highly active antiretroviral therapies (HAART). At least one cardiac abnormality was found in 89% of the participants; right ventricular (RV) dilatation in 76%, LV diastolic dysfunction in 32%, LV hypertrophy in 12%, pericardial effusion in 11% and LV systolic dysfunction in 2%. These abnormalities were more prevalent in late stages of the infection. CONCLUSIONS Cardiac abnormalities are frequent in HIV-infected children, most of which remain asymptomatic. Routine echocardiography in HIV infected children will aid prompt diagnosis.
Simulating tsunami propagation in fjords with long-wave models

Abstract. Tsunamis induced by rock slides constitute a severe hazard towards coastal fjord communities. Fjords are narrow and rugged with steep slopes, and modeling the short-frequency and high-amplitude tsunamis in this environment is demanding. In the present paper, our ability (and the lack thereof) to simulate tsunami propagation and run-up in fjords for typical wave characteristics of rock-slide-induced waves is demonstrated. The starting point is a 1 : 500 scale model of the topography and bathymetry of the southern part of Storfjorden fjord system in western Norway. Using measured wave data from the scale model as input to numerical simulations, we find that the leading wave is moderately influenced by nonlinearity and dispersion. For the trailing waves, dispersion and dissipation from the alongshore inundation on the traveling wave become more important. The tsunami inundation was simulated at the two locations of Hellesylt and Geiranger, providing a good match with the measurements in the former location. In Geiranger, the most demanding case of the two, discrepancies are larger. The discrepancies may be explained by a combinations of factors, such as the accumulated errors in the wave propagation along large stretches of the fjord, the coarse grid resolution needed to ensure model stability, and scale effects in the laboratory experiments.
The Effects of Change in Spousal Power on Intimate Partner Violence Among Chinese Immigrants

This study explored how changes in power relations within couples after immigrating from more patriarchal societies contribute to intimate partner violence (IPV). Both subjective decision-making power and objective power bases were examined in Chinese immigrant couples. Batterers and nonviolent men both experienced loss of decision-making power in favor of their spouses postimmigration. For the batterers, this loss appeared materialized by lower gains in education and lack of significant gains in income compared to their spouses. However, it was subjective power loss that was related to the batterers’ attitudes toward IPV. The study highlights the significance of understanding changes in power dynamics postimmigration among immigrants and the importance of distinguishing between subjective and material power to better capture power imbalance within couples.
Verbal subgroups of hyperbolic groups have infinite width

Let G be a non‐elementary hyperbolic group. Let w be a proper group word. We show that the width of the verbal subgroup w(G)=〈w[G]〉 is infinite. That is, there is no l∈Z such that any g∈w(G) can be represented as a product of at most l values of w and their inverses. As a consequence, we obtain the same result for a wide class of relatively hyperbolic groups.
Gender differences in the use of mental health-related services: a re-examination.

In this study we re-examine the issue of gender differences in the use of mental health services by asking (1) whether gender differences in use depend upon the specific services studied; and (2) whether statistical models which are aligned closely to help-seeking theory can explain such differences better than previously used approaches. Our analyses are drawn from two waves of data collected from a representative sample of 3,921 respondents of the Epidemiologic Catchment Area study at the Yale University site. Results indicate that although women are more likely than men to consult a physician in the general medical sector about mental health-related problems, there are no gender differences in use of the mental health specialty sector. The relationship between gender and use of the general medical sector for mental health problems also varies by psychiatric status and by attitudes toward mental health services. In the presence of a psychiatric disorder determined by the Diagnostic Interview Schedule, the likelihood of using services is highest for women with positive attitudes and for men with negative attitudes.
Structured Markov models for speech recognition

This paper proposes a new modeling of the structure of speech units as a graph consisting of base functions and a transition network. A cluster algorithm taking into account the actual temporal context of the feature vectors is used to generate the base functions, which are approximated by normal distributions. The subsequent Viterbi-based maximum-likelihood training procedure establishes the transition network and adjusts the transition probabilities. The emerging graphs for the speech units are a structure of branching and recombining trajectory segments describing statistical dependencies in the feature vector sequence within the speech units as well as in the transition regions between them. A speaker-independent evaluation shows the superiority of the proposed modeling compared to mixture-state HMMs, even for an equal number of model parameters.
THE INSPIRATION OF HOPE IN BEREAVEMENT COUNSELING

While most healthcare workers would agree that hope is necessary for healthy living, the current understanding of hope and hoping is incomplete. This article reports on a study that attempted to answer the question: Do bereavement counselors inspire hope in their clients, and if so, how? The study used a modified grounded theory method and collected data, by means of interviews, from a total sample of 12 participants, comprising bereavement counselors and ex-clients who had received bereavement counseling. The data were coded and analysed using the constant comparative method, which produced an emerging, integrated, substantive grounded theory of hope inspiration for this client group. This theory includes a core variable: the implicit projection of hope and hopefulness; and three subcore variables: forging the connection and the relationship; facilitating a cathartic release; and experiencing a good (healthy) ending. The theory indicates that this hope inspiration appears to be a subtle, unobtrusive process that was bound up with the necessary and sufficient human qualities in the counselor and the projection of these into the environment (and client).
Mediator release after nasal aspirin provocation supports different phenotypes in subjects with hypersensitivity reactions to NSAIDs

Multiple NSAID‐induced urticaria/angioedema (MNSAID‐UA) is an entity well differentiated from aspirin‐exacerbated respiratory disease (AERD), although no detailed phenotype analysis has yet been performed. The objective was to evaluate the functional characteristics of MNSAID‐UA subjects by analyzing the response to nasal lysine–aspirin challenge and measurement of nasal inflammatory mediator release compared with AERD subjects and controls.
Graft tension in anterior cruciate ligament reconstruction

The purpose of this study was to examine the effect of initial tensioning on the outcome of reconstruction of the ACL. The ACLs of 15 adult mongrel dogs were excised and reconstructed. In the first five dogs, the ACLs of both knees were reconstructed using the medial one- third of the patellar tendon. The graft was fixed under a tension of 1 N (0.22 pounds) in one knee and 39 N (8.8 pounds) in the opposite knee. In the remainder of the dogs, the reconstructions were augmented with Dacron prostheses. Tensioning of both graft compo nents in the augmented reconstructions was either with 1 N in one knee and 39 N in the contralateral knee or disproportionate tensions of 1 N and 39 N applied to the autogenous material and to the prosthesis. Sacrifice was 3 months postsurgery and results were examined with microangiography/histology and mechanical test ing. In the reconstructions with the patellar tendon alone, the biologic study showed poor vascularity and focal myxoid degeneration within the graft pretensioned with a load of 39 N. In the augmented reconstructions, the knees in which both graft materials were fixed with 1 N tension showed the strongest and stiffest reconstruc tion at 3 months. The study suggests that minimal tension should be applied to the graft materials during surgical reconstruction of the ACL.