Miracle-dz/UniFAR-FTUs huggingface dataset:
Key premises, a guide to Aedes aegypti (Diptera: Culicidae) surveillance and control

Abstract The population densities of Aedes aegypti Linneaus in four towns in Trinidad were studied using standard house-to-house inspections of all water-holding containers to determine whether persistently positive containers and premises existed over a three-month period in the wet season, from May to July 2002. From a total of 1503 houses inspected, 223 were positive with 41 persistently positive over the three month period and classified as ‘key premises’. The definition of the term key premises is described and the rationale for its utilization discussed. A total of 24,439 containers was inspected from Santa Margarita (6407), Mt Lambert (5709), St Augustine (5384) and Curepe (6939) of which 1.3% or 334 containers were positive for A. aegypti larvae and pupae. A total of 16,507 immatures of A. aegypti were retrieved from these containers which comprised 17 container types but when these were ranked according to productivity levels, only water drums (average 53.5%), buckets (22.2%), tubs and basins (8.0%), water tanks (5.4%), brick holes (4.2%) and tyres (2.0%) were significant (P < 0.001) producers. The role that key premises play in the introduction and re-infestation of A. aegypti-free communities is described and illustrated. These results suggest that A. aegypti control programmes could be more cost effective and sustainable by concentrating efforts on key premises and key containers to control mosquito densities and Dengue transmission while reducing manpower needs and insecticide use.
Human anti‐immunoglobulin antibodies interfering in immunometric assays

Human anti-immunoglobulins of low affinity may be anti-human (rheumatoid factor), anti-animal (heterophilic antibody) or both. High-affinity anti-animal immunoglobulins may develop after exposure to animal immunoglobulins, but seldom cross-react with human immunoglobulins. Measuring human anti-immunoglobulins is technically difficult and assays thus display large inter-method differences, depending on the assay method used. In immunoassays using animal immunoglobulins, human anti-animal immunoglobulins can cause both false high results (positive interference) by binding both capture and tracer assay antibodies and false low results (negative interference) by preventing the binding of tracer assay antibodies. Interference may be reduced by removal of the interfering immunoglobulins, modification of assay antibodies or by using blocking agents. Alternatively, sample dilution or a non-sense assay may be included to give a warning signal when interference is present.
Featured Article: Depletion of HDL3 high density lipoprotein and altered functionality of HDL2 in blood from sickle cell patients

In sickle cell disease (SCD), alterations of cholesterol metabolism is in part related to abnormal levels and activity of plasma proteins such as lecithin cholesterol acyltransferase (LCAT), and apolipoprotein A-I (ApoA-I). In addition, the size distribution of ApoA-I high density lipoproteins (HDL) differs from normal blood. The ratio of the amount of HDL2 particle relative to the smaller higher density pre-β HDL (HDL3) particle was shifted toward HDL2. This lipoprotein imbalance is exacerbated during acute vaso-occlusive episodes (VOE) as the relative levels of HDL3 decrease. HDL3 deficiency in SCD plasma was found to relate to a slower ApoA-I exchange rate, which suggests an impaired ABCA1-mediated cholesterol efflux in SCD. HDL2 isolated from SCD plasma displayed an antioxidant capacity normally associated with HDL3, providing evidence for a change in function of HDL2 in SCD as compared to HDL2 in normal plasma. Although SCD plasma is depleted in HDL3, this altered capacity of HDL2 could account for the lack of difference in pro-inflammatory HDL levels in SCD as compared to normal. Exposure of human umbilical vein endothelial cells to HDL2 isolated from SCD plasma resulted in higher mRNA levels of the acute phase protein long pentraxin 3 (PTX3) as compared to incubation with HDL2 from control plasma. Addition of the heme-scavenger hemopexin protein prevented increased expression of PTX3 in sickle HDL2-treated cells. These findings suggest that ApoA-I lipoprotein composition and functions are altered in SCD plasma, and that whole blood transfusion may be considered as a blood replacement therapy in SCD. Impact statement Our study adds to the growing evidence that the dysfunctional red blood cell (RBC) in sickle cell disease (SCD) affects the plasma environment, which contributes significantly in the vasculopathy that defines the disease. Remodeling of anti-inflammatory high density lipoprotein (HDL) to pro-inflammatory entities can occur during the acute phase response. SCD plasma is depleted of the pre-β particle (HDL3), which is essential for stimulation of reverse cholesterol from macrophages, and the function of the larger HDL2 particle is altered. These dysfunctions are exacerbated during vaso-occlusive episodes. Interaction of lipoproteins with endothelium increases formation of inflammatory mediators, a process counteracted by the heme-scavenger hemopexin. This links hemolysis to lipoprotein-mediated inflammation in SCD, and hemopexin treatment could be considered. The use of RBC concentrates in transfusion therapy of SCD patients underestimates the importance of the dysfunctional plasma compartment, and transfusion of whole blood or plasma may be warranted.
Matrix Metalloproteinases and Subclinical Atherosclerosis in Chronic Kidney Disease: A Systematic Review

Background. Cardiovascular disease (CVD) remains a significant problem in Chronic Kidney Disease (CKD). Subclinical atherosclerosis identified by noninvasive methods could improve CVD risk prediction in CKD but these methods are often unavailable. We therefore systematically reviewed whether circulating levels of Matrix Metalloproteinases (MMPs) and tissue inhibitors (TIMPs) are associated with subclinical atherosclerosis in CKD, as this would support their use as biomarkers or pharmacologic targets. Methods. All major electronic databases were systematically searched from inception until May 2015 using appropriate terms. Studies involving CKD patients with data on circulating MMPs levels and atherosclerosis were considered and subjected to quality assessment. Results. Overall, 16 studies were identified for qualitative synthesis and 9 studies were included in quantitative synthesis. MMP-2 and TIMP-1 were most frequently studied while most studies assessed carotid Intima-Media Thickness (cIMT) as a measure of subclinical atherosclerosis. Only MMP-2 demonstrated a consistent positive association with cIMT. Considerable variability in cIMT measurement methodology and poor plaque assessment was found. Conclusions. Although MMPs demonstrate great potential as biomarkers of subclinical atherosclerosis, they are understudied in CKD and not enough data existed for meta-analysis. Larger studies involving several MMPs, with more homogenized approaches in determining the atherosclerotic burden in CKD, are needed.
The Announcement Effect of Equity Private Placement: Evidence from Malaysia

This study examines the Malaysian stock market reaction to the announcement of equity private placement made by 127 publicly listed firms for the period from 2013 to 2015. Using standard event study methodology, the results for different event windows show zero announcement effect in response to the announcements.The finding is inconsistent with majority of past studies’ results which indicate positive announcement effect.Thus, it can be concluded that the market is indifferent to the announcement of private placement and both hypotheses cannot be applied to explain the announcement effect of equity private placement in Malaysia.
Social media led co-creation of knowledge in developing societies: SME’s roles in the adoption, use and appropriation of smartphones in South Asia

Abstract Social media supports the creative economy through its involvement in the adoption and appropriation of new innovation and accelerates economic growth. The current paper expands on this notion by identifying and analyzing the interaction between social media-based communities and small and medium enterprises (SMEs), as it examines how social media contributes to the knowledge co-creation and supports the adoption, use and appropriation of smartphones in South Asian countries, which are inhabited by approximately 1.6 billion people. The findings obtained through virtual ethnography (VE) provide insights into the dynamics and kinetics of knowledge co-creation and how that benefits large multinationals, small local businesses and consumers in developing societies. As such, we advance the knowledge management scholarship by presenting a holistic model of co-creation of knowledge involving multiple stakeholders.
Effect of carbohydrate supplementation on simulated exercise of rugby league referees

This investigation evaluated the effectiveness of supplementing eight elite rugby league referees with a 6% maltodextrin (Md) solution whilst undertaking a simulated rugby league game. The simulation was based on motion analysis of six rugby league matches. Subjects undertook two trials of repetitive 20-m shuttle activity on an indoor track. During one trial 200 ml of Md was ingested at eight time points and in the other trial a similarly tasting placebo (Pl) was administered. A single-blind, counterbalanced design was employed. The simulation involved subjects performing four, 10-min blocks of shuttle activity before a 10-min break was instigated. Three further 10-min blocks of shuttle activity were also performed before a performance test to volitional exhaustion involving 20-m shuttles at paces varying between 55 and 95% of a pre-determined [Vdot]O2 max was undertaken. Timed 15-m sprints took place during each of the 10-min blocks. The rating of perceived exertion (RPE), and blood glucose and lactate concentrations were also determined throughout. The mean number of shuttles to exhaustion was significantly greater with Md ingestion than with Pl ingestion (57 ± 19 vs. 43 ± 15; p < 0.05), while the mean 15-m sprint times were significantly shorter for the Md than the Pl condition (2.40 ± 0.09 s vs. 2.51 ± 0.14 s; p < 0.01). The mean RPE was ∼ 5.2% lower during Md than Pl ingestion, the values being significantly different (Md: 12.07 ± 0.32; Pl: 12.73 ± 0.28; p < 0.01). Maltodextrin ingestion significantly elevated blood glucose levels compared with placebo (F(1,7) = 18.07: p < 0.01), although no significant differences were apparent for blood lactate levels (F(1,7) = 4.39; p > 0.05). These results highlight the beneficial eVects of maltodextrin ingestion on work-rates of rugby league referees in a simulation of a game? s activity. The improvement may be related to higher circulating concentrations of blood glucose.
Interobserver and intermodality agreement for detection of small bowel Crohn's disease with MR enterography and CT enterography

Background: Magnetic resonance enterography (MRE) and computed tomography enterography (CTE) visualizes small bowel Crohn's disease (CD) and its complications with high accuracy. The aim of this study was to determine the interobserver and intermodality agreement for detection of small bowel CD. Methods: Fifty patients with suspected or known CD were included in the study and all patients underwent MRE and CTE on the same day. Four radiologists with experience in MRE and CTE techniques participated. Observers were blind to patient histories, results of ileocolonoscopies, and other small bowel examinations. Readers assessed the image quality, the presence of small bowel CD, and seven findings consistent with CD. Results: The image quality was better with CTE than MRE (P < 0.001) but the diagnostic yields were comparable (P = 0.4). For detection of small bowel CD, the interobserver agreement was substantial in CTE (&kgr; = 0.64) and moderate in MRE (&kgr; = 0.48). The intermodality agreement was fair to substantial (&kgr; = 0.40‐0.64) for different observers. Two abscesses were detected and confirmed at subsequent surgery. One abscess was not detected with MRE and only recorded by two observers in CTE. A total of 10 fistulas were detected: three were confirmed at subsequent surgery and four were false‐positive findings. Conclusions: MRE and CTE have comparable diagnostic yields in patients with suspected or known CD. However, CTE provides better image quality and interobserver agreement. In a substantial number of patients the diagnosis of small bowel CD is observer‐ and modality‐dependent. (Inflamm Bowel Dis 2010;)
Reciprocal Negative Disclosures: An Application of Expectancy Violations Theory

Social support can dramatically improve an individual’s ability to confront and negotiate stressful life changes, and self-disclosure is one means through which individuals can create and maintain interpersonal relationships that can result in that much-needed social support (Cohen, Mermelstein, Kamarck, & Hoberman, 1985; Cohen & Wills, 1985; Cobb, 1976). However, during communication the relationship between the people interacting can influence what disclosures adhere to the communicators’ expectations and what types of disclosures violate those expectations. Experiencing a communication expectation violation can impact (negatively or positively) individuals’ perception of both their peer and the interaction itself (Burgoon, 1978). This study utilized Expectancy Violations Theory (EVT) to examine graduate students’ expectations of reciprocal negative disclosures with their peers. Within the academic context it is important to better understand the disclosure expectancies that graduate students have of their peers. This is because self-disclosure can serve as a key means by which students develop interpersonal relationships and gain social support from one another as they navigate the challenges of graduate school and the organizational culture of their programs. No literature exists that utilizes expectancy violations theory to examine the impact that violating organizational cultural expectations
Board Members and Board Characteristics Effect on Bank Performance in Turkey

This study analyzes the effect of board member’s characteristics (political, national and gender) and board characteristics (board size, CEO-chairman duality) on bank performance, with the main attention being on the political board directors, in Turkey. By making use of a sample of 31 commercial banks in Turkey, during the period of 2002-2013, our empirical evidence shows that political board directors have a significantly negative impact on bank performance. We found new evidence that not only political board directors inhibit bank performance, but politically connected banks also have less accounting performance than their nonconnected counterparts. Similarly, our results indicate that foreign board directors also affect negatively bank performance. Furthermore, our results demonstrate that gender diversity, board size and CEO-Chairman duality has no impact on bank performance. Our results are robust to the alternative time-period and estimation models.
Lack of influence of test meal fatty acid composition on the contribution of intestinally-derived lipoproteins to postprandial lipaemia

The extent and duration of postprandial lipaemia have been linked to risk of CHD but the influence of dietary variables on, and the relative contributions of, exogenous (chylomicron) and endogenous (VLDL) triacylglycerols to the total lipaemic response have not been comprehensively evaluated. In the present study the triacylglycerol, apolipoprotein (apo) B-48 and retinyl ester (RE) responses to three test meals of varying monounsaturated (MUFA) and saturated fatty acid (SFA) content were measured in the triacylglycerol-rich lipoprotein (TRL) fraction of plasma (ρ = 1·006 g/ml) for 9 h after meal consumption. Fifteen healthy normolipidaemic young men consumed, on separate occasions, three test meals which were identical apart from their MUFA and SFA contents. Expressed as a percentage of total energy the MUFA/SFA contents of the meals were: (1) 12 %/17 %; (2) 17 %/12 % and (3) 24 %/5 %. The contribution of the intestinally-derived lipoproteins (chylomicrons) to the lipaemic response was investigated by determining the time to reach peak concentration and the total and incremental areas under the time response curves (AUC and incremental AUC) for RE, apoB-48 and triacylglycerol in the TRL fraction. No significant differences in these measurements were observed for the three meals. However, visual comparison of the postprandial responses to the three meals suggested that as meal MUFA content increased there was a tendency for the triacylglycerol, apoB-48 and RE responses to become biphasic as opposed to the typical monophasic response seen with the 12 % MUFA/17 % SFA meal. Comparison of the apoB-48 and RE responses for the three test meals confirmed other workers’ findings of delayed entry of RE relative to apoB-48 in TRL. The value of the two markers in investigating dietary fat absorption and metabolism is discussed.
An Overview of German Centers of Corporate Dominance and Motives for Corporate Headquarters Relocation

The purpose of this paper is to identify the centers of corporate dominance in Germany, and the main drivers of recent headquarter relocations within the country. The analysis is based on a literature review, a database comprising the 10,000 most significant companies in Germany and additional research for qualitative input to support the interpretation of the findings. The findings show that corporate dominance in Germany is decentralized. Centers with relative corporate dominance tend to host a higher proportion of public limited companies. These public limited companies had a turnover of over one billion Euros, and most of these companies were founded after the year 2000. The main drivers for recent HQ relocations were corporate restructuring (mergers and demergers) and the centralization of functions. Furthermore, it has been found that differences in the trade tax burden between municipalities have had no influence on recent relocation decisions within Germany.
Lipid Peroxidation, Caspase-3 Immunoreactivity, and Pyknosis in Late-Gestation Fetal Sheep Brain after Umbilical Cord Occlusion

Umbilical cord occlusion (UCO), a known risk factor for perinatal brain damage, causes severe fetal asphyxia leading to oxidative stress, lipid peroxidation, and cell death. We have determined the effects of two 10-min UCO on the distribution of the lipid peroxidation marker 4-hydroxynonenal (4-HNE) and the activated form of the apoptosis marker caspase-3 in the brains of late-gestation fetal sheep. UCO caused asphyxia, hypertension, and bradycardia, but these parameters normalized 2 h after the occlusion. At postmortem, 48 h after the second UCO there were significantly higher numbers of 4-HNE–positive cells in all layers of the hippocampus and cerebellum, the parietal cortex, substantia nigra, caudate nucleus, putamen, and thalamus compared with control brains. 4-HNE immunoreactivity was also found in white matter tracts of the subcallosal bundle, external medullary lamina, reticular thalamic nucleus, and cerebellar fiber tracts only in UCO brains. Double-labeling identified these cells as predominantly neurons and astrocytes, with oligodendrocytes showing lower levels of 4-HNE immunoreactivity. After UCO, the number of caspase-3-immunoposotive cells was increased significantly in the hippocampal CA1, molecular layer and dentate gyrus, ventrolateral thalamic nucleus, substantia nigra, putamen, and cerebellar granular and molecular layers compared with controls. Double-labeling revealed caspase-3 immunoreactivity was mainly in neurons, and to lesser extent in astrocytes and oligodendrocytes. Pyknotic cell numbers were significantly increased in hippocampal CA1 and CA3, parietal cortex, caudate nucleus, putamen, and cerebellar Purkinje cells after UCO. These data indicate that brief asphyxia induces widespread lipid peroxidation involving all cell types of the fetal brain and apoptosis in both neurons and glia.
TIA Triage in Emergency Department Using Acute MRI (TIA-TEAM): A Feasibility and Safety Study

Background Positive diffusion weighted imaging (DWI) on MRI is associated with increased recurrent stroke risk in TIA patients. Acute MRI aids in TIA risk stratification and diagnosis. Aim To evaluate the feasibility and safety of TIA triage directly from the emergency department (ED) with acute MRI and neurological consultation. Methods Consecutive ED TIA patients assessed by a neurologist underwent acute MRI/MRA of head/neck per protocol and were hospitalized if positive DWI, symptomatic vessel stenosis, or per clinical judgment. Stroke neurologist adjudicated the final TIA diagnosis as definite, possible, or not a cerebrovascular event. Stroke recurrence rates were calculated at 7, 90, 365 days and compared with predicted stroke rates derived from historical DWI and ABCD2 score data. Results One hundred twenty-nine enrolled patients had a mean age of 69 years (±17) and median ABCD2 score of 3 (interquartile range [IQR] 3–4). During triage, 112 (87%) patients underwent acute MRI after a median of 16 h (IQR 10–23) from symptom onset. No patients experienced a recurrent event before imaging. Twenty-four (21%) had positive DWI and 8 (7%) had symptomatic vessel stenosis. Of the total cohort, 83 (64%) were discharged and 46 (36%) were hospitalized. By one-year follow-up, one patient in each group had experienced a stroke. Of 92 patients with MRI and index cerebrovascular event, recurrent stroke rates were 1·1% at 7 and 90 days. These were similar to predicted recurrence rates. Conclusion TIA triage in the ED using a protocol with neurological consultation and acute MRI is feasible and safe. The majority of patients were discharged without hospitalization and rates of recurrent stroke were not higher than predicted.
Effect of Dentinal Fluid Composition on Dentin Demineralization in vitro

Dentin demineralization is reduced by perfusion with water. We hypothesized that a simulated dentinal fluid (SDF) that contains albumin, in addition to electrolytes, would be more effective in reducing dentin demineralization than water alone, and this effect would increase with increasing flow rate of SDF. Perfusion rate in tooth segments that carried buccal cervical dentin windows was measured in a fluid transport set-up. These windows were then demineralized under perfusion with water, or SDF at 1.47 kPa for 31 days. We analyzed integrated mineral loss and lesion depth with the use of transverse microradiography (TMR), which revealed that 38% more mineral dissolved from dentin lesions perfused with water than from those perfused with SDF. The former were also 18% deeper. Flow rate of dentinal fluid showed no correlation with demineralization. We concluded that composition of dentinal fluid is an important determinant of the rate of lesion formation and progression in dentin.