Miracle-dz/UniFAR-FTUs huggingface dataset:
Detection of apoptotic epidermal cells in a dog with toxic epidermal necrolysis.

: It has been reported that apoptotic keratinocytes were not observed in dogs with toxic epidermal necrolysis (TEN). Here, we describe a dog with TEN in which apoptotic cells were found in the epidermis. A 13-year-old female mongrel dog was presented with acute and extensive erythema, vesicles and ulcerations, especially on the ventral skin and visible mucous membranes. The dog also exhibited anorexia and lethargy. The dog was administrated oral amoxicillin 5 days before development of the skin lesions. Histopathological examination of the skin lesions revealed a full-thickness epidermal coagulative necrosis with lymphocytic exocytosis compatible with TEN. Immunohistochemical analyses indicated that in ﬁ ltrative lymphocytes were positive for CD3. In addition, TdT-mediated dUTP-end labeling (TUNEL) positive cells indicated there were apoptotic cells in the epidermis including keratinocytes. Based on these ﬁ ndings, T cell-mediated apoptosis of the epidermal keratinocytes was considered as a possible pathomechanism of epidermal necrolysis in the present case.
A systematic review and meta-analysis of the association between HOTAIR polymorphisms and susceptibility to breast cancer

Introduction Many studies are drawing attention to the associations of HOTAIR polymorphisms and susceptibility to breast cancer, while the results remain inconsistent. We conducted a meta-analysis on the association of four common HOTAIR polymorphisms with breast cancer susceptibility. Material and methods Eligible published articles were searched in PubMed, Embase, Cochrane library databases and Web of Science databases up to July 2019. Odds ratios with 95% confidence intervals were used to identify potential links between lncRNA HOTAIR polymorphisms and the risk of breast cancer. Results Our results showed no significance in all genetic models of all four SNPs. Pooled analyses detected crucial links between the rs1899663 polymorphism and decreased susceptibility to breast cancer in five genetic models rather than the dominant model in the hospital-based control subgroup. For the rs920778 polymorphism, we found that it significantly decreased breast cancer risk under recessive, homozygous and heterozygous models within the west Asian subgroup and increased breast cancer risk under allele and dominant models within the East Asian subgroup. Additionally, rs920778 polymorphism decreased breast cancer risk under recessive and heterozygous models in the hospital-based control subgroup. However, no significant association was observed between the rs4759314 polymorphism and breast cancer risk in overall and stratified analyses. For rs12826786 polymorphism, it was greatly associated with decreased breast cancer risk under recessive, homozygous and heterozygous models in the hospital-based control subgroup. Conclusions HOTAIR rs920778, rs1899663 and rs12826786 polymorphisms may contribute to breast cancer susceptibility.
Outcomes and risk factors of postoperative hepatic dysfunction in patients undergoing acute type A aortic dissection surgery.

Background Postoperative hepatic dysfunction (HD) increases the morbidity and mortality risk after cardiac surgery; however, only a few studies have specifically focused on acute type A aortic dissection (AAAD) surgery. We explored the possible risk factors and outcomes of early postoperative HD in patients with AAAD undergoing surgery. Methods All patients who underwent AAAD surgery at our institution from April 2015 to April 2017 were retrospectively evaluated. Postoperative model for end-stage liver disease (MELD) score was used to define HD. Independent risk factors for HD were determined by multivariate logistic analysis. Results Two hundred fifteen patients with AAAD met the inclusion criteria. The incidence rate of early postoperative HD was 60.9%, and the rate of in-hospital mortality was 16.8%. Patients with a high postoperative MELD score had longer mechanical ventilation time, longer durations of intensive care unit (ICU) stay, and higher in-hospital mortality. During the postoperative period, patients with AAAD complicated by HD needed continuous renal replacement therapy (CRRT), reintubation, tracheostomy, and blood transfusion more frequently. Aortic cross clamp (ACC) time [per 10 min higher; odds ratio (OR): 1.216, 95% confidence interval (CI): 1.017-1.454, P=0.032], postoperative leucocytes (per 2×109/L higher; OR: 1.161, 95% CI: 1.018-1.324, P=0.026), postoperative respiratory dysfunction (OR: 3.176, 95% CI: 1.293-7.803, P=0.012), and postoperative low cardiac output syndrome (LCOS) (OR: 12.663, 95% CI: 1.432-111.998, P=0.022) were independent risk factors associated with HD in patients undergoing AAAD surgery. Conclusions Postoperative HD prolongs mechanical ventilation time and ICU stay, and is associated with increased in-hospital mortality among patients who undergo AAAD surgery. Several factors are associated with a high postoperative MELD score.
Pleural Biopsy And Adenosine Deaminase Enzyme Activity In Effusions Of Different Aetiologies

Adenosine deaminase enzyme (ADA) activity was estimated in 73 patients of pleural effusion. Patient were classified into five different groups based on aetiological diagnosis made on pleural biopsy and fluid examinations. ADA concentrations were significantly higher in tubercular effusion. Four of 26 patients (15.4%) with malignant pleural effusion had also shown raised ADA levels. All these patients had predominantly lymphocytic effusion. Though a higher ADA value is strongly suggestive of tubercular effusion, malignancy cannot be altogether excluded. However, ADA activity less than 40 IU/L excludes tubercular aetiology.
The Wow Factor: Global Research Compendium on the Impact of the Arts in Education

Commissioned by UNESCO in 2004, and carried out in collaboration with the Australia Council for the Arts and the International Federation of Arts and Cultural Agencies (IFACCA), Bamford conducted the first international research and analysis of the impact of the arts in education on children and young people. ‘The Wow Factor’ (also available in Korean, Mandarin, Spanish) is the direct outcome of the research project and provides a knowledge base for understanding the organisational frameworks and conditions that regulate arts-rich education around the world.The research, led by Bamford, used an extensive survey process distributed to every country in the world and completed by the Ministries of Education, Arts and Culture. Case studies were used to determine the impact of art-rich programmes on the education of children and young people, and the results were analysed using numerical and qualitative triangulation, and cross-checked with 170 empirical case studies. Using extensive quantitative and qualitative methods to draw conclusions about the role of arts-rich programmes, Bamford developed internationally comparable standards for quality arts education, and identified a number of concrete educational, cultural and social benefits of arts education. This research has become a reference point for national policies in arts education including The Netherlands, Belgium, Denmark, Australia, Czech Republic, Korea, France, Germany and South Africa; was featured in the Dossier l’Education Artistique (no.42, 2006), and Cuadernos de Pedagogia (November 2005). Bamford has presented a number of papers including the opening keynote at the UNESCO World Conference on Arts Education (Lisbon, March 2006) and was presented with Portuguese medal in recognition of services to arts education. ‘The Wow Factor’ has been widely reviewed in professional journals, including the International Journal of Art & Design Education (Volume 25, 2006).
Neonatal neuroimaging after repair of congenital diaphragmatic hernia and long-term neurodevelopmental outcome

Objective Previous outcome reports of congenital diaphragmatic hernia (CDH) have described neuroimaging anomalies and neurodevelopmental impairment. However, the link between imaging and outcome has not been described. We aimed to determine whether routine postoperative neonatal neuroimaging in infants with CDH detects later neurodevelopmental impairment. Methods In a prospective cohort study within a clinical service in The Royal Children’s Hospital Newborn Intensive Care. Cerebral ultrasound was performed in 81 children and MRI in 57 children who subsequently underwent neurodevelopmental follow-up after surgery for CDH. MRI scans were analyzed using a scoring system designed to identify injury, maturation and volume loss. Neurodevelopmental assessment occurred at 2 years (48) and neurocognitive assessment at 5 years (26) and/or 8 years (27). Brain imaging scores corrected for gestational age at scan time were correlated with outcome measures, adjusting for known clinical confounders. Results Clinically significant findings were identified on MRI of 16 (28%) infants. Mean scores were in the normal range for all domains assessed at each age. Language impairment was seen in 23% at 2 years and verbal intellectual impairment in 25% at 8 years. Mean cognitive scores were lower in 2-year-old children with white matter injury on MRI (p=0.03). Mean motor scores were lower in 2-year-old children with brain immaturity (p=0.01). Associations between MRI and 5-year and 8-year assessments were no longer significant when adjusting for known clinical confounders. Conclusions Neuroimaging abnormalities were associated with worse neurodevelopment at 2 years, but not with later neurocognitive outcomes, after accounting for clinical risk factors.
An appraisal of the effect of nursing location on weaning weight of piglets and its dependence on the feeding of essential oils to sows

OF THESIS An appraisal of the effect of nursing location on weaning weight of piglets and its dependence on the feeding of essential oils to sows The objective of these studies was to evaluate the effect of piglet nursing location on weaning weight, and its dependence on essential oil supplementation on sow and piglet performances. Piglets that nursed anterior teat pairs had heavier weaning weights and higher gain for the lactation period. Additionally, piglet birthweight did not impact their overall teat selection and nursing location. These results provide some insight into the biological aspects of sow milk production, and implied that milk yield may vary between teat pairs along the udder line. Supplementation of essential oils (EO) during late gestation and lactation had no effect on sow fecal dry matter (DM), immunoglobulin content of colostrum and milk, but it did increase the lactose content in milk from sows supplemented with EO, with an increase from 5.84% to 5. 97% (P = 0.04). There was an increase in sow weight loss during lactation (P = 0.002), and there was a significant effect on piglet birthweight, with sows supplemented with EO producing heavier piglets at birth, 1.56 kg in EO sows, compared to 1.49 kg in the control (CON) sows (P = 0.03). Overall, piglet weaning weight is impacted by their selected nursing location along the udder line. Supplementation of EO may have limited effects on sow performance, such as fecal dry matter (DM) but may positively impact piglet birthweight. Furthermore, including EO into sow diets during late gestation and lactation can potentially impact the nutrient levels of sow milk.
Neonatal Intestinal Obstruction: A 5 Year Experience in a Tertiary Hospital in Enugu, Nigeria

Background: Neonatal intestinal obstruction is one of the most common surgical emergencies in a newborn requiring the services of a pediatric surgeon. This study reports the etiology, sex incidence, age of presentation, management and outcome of neonatal intestinal obstruction in pediatric surgical unit of a tertiary hospital in Enugu, Nigeria. Methodology: This was a retrospective study of neonates who presented, at Enugu State University Teaching Hospital, with intestinal obstruction over a 5-year period. Result: Thirty five neonates were recruited into the study. There were 24 (68.6%) males and 11 (31.4%) females. Five patients (14.3%) were delivered before term (preterm) while thirty patients (85.7%) were delivered at term. Most of the patients (54.3%) presented after 72 hours from onset of symptoms. Abdominal distension was the most common symptomatology recorded in our patients. Necrotizing enterocolitis was the most common etiology in our patients accounting for 17 neonates (48.6%). This was followed by anorectal malformation 5 (14.3%), obstructed hernia 4 (11.4%), intestinal atresia 4 (11.4%), Hirschsprung’s disease 3 (8.6%), meconium plug 2 (5.7%). Colostomy formation was the most common surgical procedure performed. Twenty percent of our patients developed post-operative complication and mortality was 22.9%. Conclusion: Necrotizing enterocolitis is the most common cause of neonatal intestinal obstruction in the current study. With the mortality of 22.9%, the outcome in our patients is still poor and requires some improvements.
Epidemiology and Resistance Levels of Enterobacteriaceae Isolates from Urinary Tract Infections Expressed as Multiple Antibiotic Resistance (MAR) Indices

Aims: To assess the epidemiology of UTIs affecting inpatients and outpatients and the antibiotic resistance levels, expressed as multiple antibiotic resistance (MAR) indices from the isolated species at a tertiary-care hospital in Hungary, during a 10-year study period. Study Design: Retrospective microbiological study. Place and Duration of Study: 1st of January 2008 - 31st of December 2017 at the University of Szeged, which is affiliated with the Albert Szent-Györgyi Clinical Center, a primary- and tertiary-care teaching hospital in the Southern Great Plain of Hungary. Methodology: Antimicrobial susceptibility testing (AST) was performed using disk diffusion method and when appropriate, E-tests on Mueller–Hinton agar (MHA) plates. The multiple antibiotic resistance (MAR) index of the isolates was determined. Results: During the 10-year study period, the Institute of Clinical Microbiology received 21,150 urine samples from outpatient clinics and 19,325 samples from inpatient departments that turned out to be positive for a significant urinary pathogen. Out of the positive urine samples, E. coli represented the overwhelming majority of all positive urine samples. The resistance levels in inpatient isolates were higher than in the outpatient isolates (average MAR indices: 0.347 vs. 0.410, 0.267 vs. 0.435 and 0.318 vs. 0.473 for the E. coli/Klebsiella, CES and Proteae group, respectively). Conclusion: As the therapeutic options are becoming increasingly limited in the current antibiotic resistance climate, more effort should be put into the prudent use of antibiotics and the development of novel antimicrobial agents.
Child and adolescent obesity in Asia

Childhood obesity is a rapidly growing public health problem in developing countries. World Health Organization estimated that in 2010, of 43 million overweight/obese children worldwide, about 35 million of them were living in developing countries. In this chapter we will present case studies on what is happening in Vietnam, Indonesia, Thailand and China, the developing countries in the Southeast and East Asia that are undergoing rapid socioeconomic development and urbanisation. We will also explore the possibilities of what the governments and communities can do to address the emerging childhood obesity epidemic in these countries.
Beliefs About HPV Vaccine’s Success at Cervical Cancer Prevention Among Adult US Women

Abstract Background Beliefs are known to be a key determinant in vaccines’ uptake. However, little is known about beliefs surrounding the success of the human papillomavirus (HPV) vaccine in preventing cervical cancer in the United States. Methods Data from the Health Information National Trends Survey 5 Cycle 1 (2017) were analyzed for 1851 female respondents aged 18 years and older. Weighted multinomial logistic regression was employed to determine predictors of beliefs in the success of the HPV vaccine in preventing cervical cancer. Results Overall, 29.8% of women believed that HPV vaccine is successful in preventing cervical cancer, 6.6% believed it is not successful, and 63.6% did not know if the HPV vaccine is successful. Non-Hispanic blacks (adjusted odds ratio [aOR] = 1.80, 95% confidence interval [CI] = 1.16 to 2.79), women with no more than 12 years of education (aOR = 2.05, 95% CI = 1.17 to 3.60), those who did not know if they were advised by a health-care provider to get an HPV shot within the last 12 months (aOR = 4.19, 95% CI = 1.39 to 12.60), and those unaware of a family cancer history (aOR = 5.17, 95% CI = 1.48 to 18.21) were more likely to not know whether the HPV vaccine prevents cervical cancer. Women younger than 65 years were more likely than elderly to believe that the HPV vaccine is not successful at preventing cervical cancer. Conclusions A substantial proportion of US women are uninformed about the HPV vaccine. To accelerate progress in the HPV vaccine’s uptake, future interventions should incorporate educational programs, particularly targeting Non-Hispanic blacks, women with a lower level of education, and those younger than 65 years. Health-care providers’ participation in promotion of patient education about HPV vaccination should also be increased.
Lameness scoring systems for cattle in dairy farms

Dairy cow locomotion and its correct interpretation are extremely important for assessment of normal locomotion and lameness. In the literature, cattle lameness is often described as deviation from the normal locomotion due to pain or discomfort in the region of feet and hooves. A major part of the existing locomotion scoring systems are based upon identification of changes in normal locomotion, but sometimes, the interpretation of these changes is difficult when described in the best possible way. The existing risk related to the correct evaluation predetermines the development of scoring systems for clinical lameness. Many systems are used to score the locomotion of both healthy and diseased cows. The natural stance of cows could also mislead researchers and farmers during the evaluation. Pathological deviations in the region of feet and hooves are not always related to visible alterations in cows' behaviour. Very often, hoof pathology without clinical manifestation could be observed. The intensive mechanisation of cattle husbandry and the reduced contact between animals and men further contribute to the increased incidence of wrong evaluation and flaws in cattle lameness recognition, especially in the early stages. This fact has encouraged attempts for creating accurate practical locomotion scoring systems that could assist in detection of all deviations from normal locomotion in dairy cows.
An investigation of the factors that influence the career aspirations of Year 12 science students

What has become apparent in recent years is the lack of upper secondary students choosing science related subjects in their final years of schooling. Even of those students who do choose science subjects to study in Years 11 and 12 in Australia, many tend to choose non-science pathways for tertiary education options (Department of Education, Science and Training, 2003). This is a worrying trend, given the numbers of science professionals and teachers required in the new age of technology. By investigating a sample of Western Australian Year 12 students that study any science related subject, it is expected that there may be some underlying factors that can be identified that play important roles in their career aspirations. Previous research suggests that these factors will most likely be a combination of social, environmental and individual influences. Science learning experiences, albeit positive or negative, also most certainly determine an individual's interest in science. It is important to understand why science is failing to capture the interest of our best students, who potentially could contribute intellectually to the future of Australian science. A sample of five secondary metropolitan schools was involved in the collection of data. Using a qualitative case study research method, Year 12 science students, aged 16 to 17 years, were surveyed on aspects of career aspirations and experiences in science. Focus groups from each school participated in a narrative inquiry with the author to further probe their thoughts about career choices in relation to science learning experiences. Staff involved in helping students with their career decisions such as Career Advisors, Year 12 Coordinators and science teachers were also interviewed. In summary, it can be noted, that whilst many of our Year 12 science students are reported high levels of enjoyment of science, there is significant room for improvement. Teachers are seen as a vital link in fostering students' enjoyment of science, and need to be able to tea.ch science in a relevant fashion, enabling students to understand and to be able to explain the concepts of science. Teachers also have
Maternal and perinatal outcomes in urgent referral and non-referral cases of emergency cesarean section at a district hospital in Zambia: a retrospective observational study

Maternal and perinatal outcomes in urgent referral and non-referral cases of emergency cesarean section at a district hospital in Zambia: a retrospective observational study Yasuhiro Miyoshi Zimba Mission Hospital, Zimba, Zambia, National Hospital Organization Nagasaki Medical Center, Nagasaki, Japan Corresponding author: Yasuhiro Miyoshi, National Hospital Organization Nagasaki Medical Center, Nagasaki, Japan
Delayed presentation of congenital tibial pseudarthrosis and neurofibromatosis: a difficult union

Abstract Background: A new case of congenital pseudarthrosis of the tibia (CPT) presents yearly to CSC, but treatment is prolonged, and not always successful. Objective: To study the outcomes of treatment, and to determine whether a relationship with neurofibromatosis (NF) was of significance. Methods: A review of the medical records at our centre revealed 11 cases of CPT, 5 of which were associated with neurofibromatosis. Results: Most patients had multiple operations for their case of CPT, which did finally lead to union in 6 out of 6 cases with no NF, but in only 1 case out of 5 when NF was present. Conclusion: Late presentation and severe deformity can be overcome, and union can be achieved, but NF has a deleterious effect on obtaining union.
The predictive value of sFlt-1/PIGF ratio in high risk patients for the development of preeclampsia

Background: Hypertensive disorders of pregnancy constitute a major cause of maternal morbidity and mortality. Pre-eclampsia/eclampsia ranks second only to haemorrhage as a specific, direct cause of maternal mortality. A number of markers have been under study for the early detection of this disease. The study aims to evaluate the predictive value of sFlt-1/PlGF ratio for preeclampsia.Methods: This study was conducted in the Department of Gynaecology and Obstetrics of ASCOMS hospital, Jammu for a period of 6 months from Jan 2019 to June 2019. 50 antenatal patients attending the outpatient department with risk factors for developing preeclampsia were enrolled in the study. Their sFlT-1/PIGF ratio was determined at gestational age of 20 weeks to 37 weeks and its predictive value was evaluated.Results: In the present study, 8 patients developed preeclampsia subsequently. The mean sFlt-1/PIGF ratio values were significantly higher in the patients who developed preeclampsia (73.5) than who did not develop the disease (26.07). The positive predictive value at 1 week was 41.66% and negative predictive value was 100%. At 4 weeks, positive predictive value was 66.66% and negative predictive value was 100%. Conclusions: The present study suggests sFlt-1/PIGF ratio values are useful marker was a predictor of preeclampsia and values >38 were associated with preeclampsia. It is more useful in ruling out preeclampsia than ruling in the disease.