Miracle-dz/UniFAR-FTUs huggingface dataset:
Cancer Cell ASXL 1 Loss Inhibits PRC 2 in Myeloid Leukemia syndrome and z 10 % – 15 % of patients with myeloproliferative neoplasms and acute myeloid leukemia

Omar Abdel-Wahab,1,12 Mazhar Adli,2,12 Lindsay M. LaFave,1,3,12 Jie Gao,5 Todd Hricik,1 Alan H. Shih,1 Suveg Pandey,1 Jay P. Patel,1 Young Rock Chung,1 Richard Koche,2 Fabiana Perna,4 Xinyang Zhao,6 Jordan E. Taylor,7 Christopher Y. Park,1 Martin Carroll,8 Ari Melnick,9 Stephen D. Nimer,11 Jacob D. Jaffe,7 Iannis Aifantis,4 Bradley E. Bernstein,2,* and Ross L. Levine1,10,* 1Human Oncology and Pathogenesis Program and Leukemia Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA 2Howard Hughes Medical Institute, Broad Institute of Harvard and MIT, Department of Pathology, Massachusetts General Hospital, and Harvard Medical School, MGH-Simches Research Building, CPZN 8400,185 Cambridge Street, Boston, MA 02114, USA 3Gerstner Sloan Kettering School of Biomedical Sciences 4Molecular Pharmacology and Chemistry Program Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA 5Howard Hughes Medical Institute and Department of Pathology, New York University School of Medicine, New York, NY 10016, USA 6Department of Biochemistry and Molecular Genetics, University of Alabama, Birmingham, AL 35233, USA 7Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA 8Division of Hematology and Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA 9Division of Hematology/Oncology 10Biochemistry and Molecular Biology Program Weill Cornell Medical College, New York, NY 10065, USA 11Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USA 12These authors contributed equally to this work *Correspondence: bernstein.bradley@mgh.harvard. edu (B.E.B.), leviner@mskcc.org (R.L.L.) http://dx.doi. org/10.1016/j.ccr. 2012.06. 032
econstor Make Your Publications Visible . A Service of zbw

This paper provides an explanation for why the sunk cost bias persists among firms in a competitive environment in which rich learning possibilities are allowed. We envision firms that experiment with cost methodologies that are consistent with real-world accounting practices, including ones that confuse the relevance of variable, fixed, and sunk costs to pricing decisions. Firms follow “naive” adaptive learning to adjust prices and reinforcement learning to modify their costing methodologies. Costing and pricing practices that increase profits are reinforced. We show that all firms eventually display the sunk cost bias in their pricing behavior.
Velocity and mass bias in the distribution of dark matter haloes

The non-linear, scale-dependent bias in the mass distribution of galaxies and the underlying dark matter is a key systematic affecting the extraction of cosmological parameters from galaxy clustering. Using 95 million haloes from the Millennium-XXL N-body simulation, we find that the mass bias is scale independent only for k < 0.1 h Mpc−1 today (z = 0) and for k < 0.2 h Mpc−1 at z = 0.7. We test analytic halo bias models against our simulation measurements and find that the model of Tinker et al. is accurate to better than 5 per cent at z = 0. However, the simulation results are better fitted by an ellipsoidal collapse model at z = 0.7. We highlight, for the first time, another potentially serious systematic due to a sampling bias in the halo velocity divergence power spectra which will affect the comparison between observations and any redshift-space distortion model which assumes dark matter velocity statistics with no velocity bias. By measuring the velocity divergence power spectra for different sized halo samples, we find that there is a significant bias which increases with decreasing number density. This bias is approximately 20 per cent at k = 0.1 h Mpc−1 for a halo sample of number density n¯=10−3(h/ Mpc)3 at both z = 0 and 0.7 for the velocity divergence auto power spectrum. Given the importance of redshift-space distortions as a probe of dark energy and the major ongoing effort to advance models for the clustering signal in redshift space, our results show that this velocity bias introduces another systematic, alongside scale-dependent halo mass bias, which cannot be neglected.
Mergers and Acquisitions: The Performance of the Acquiring Firm-Empirical Study of Cheverontexaco

This paper analyzes a merger in the oil industry; in the case of Chevron and Texaco. Oil is assumed to be a homogeneous good which is produced by a small number of firms with different unit costs. Merger formation is endogenously explained as a result of cooperative decisions. It is shown that merger participants are very asymmetric if prior costs of production differences are moderate. If cost differences are large, however, the more efficient firms participate in the mergers to enjoy production efficiency, while the least efficient firms are not attractive partners and, therefore, remain independent in the post-merger market. Moreover, the research tries to investigate Chevron share returns if the merger has achieved its goal of maximizing shareholders wealth.
Primary Culture of Rat Trigeminal Ganglion Neurons after Retrograde Labeling of DPA Neurons Rat

Mechanosensitive ion channels have been suggested to be expressed in dental primary afferent (DPA) neurons to transduce the movement of dentinal fluid since the proposal of hydrodynamic theory. Piezo2, a mechanosensitive, rapidly inactivating (RI) ion channel, has been recently identified in dorsal root ganglion (DRG) neurons to mediate tactile transduction. Here, we examined the expression of Piezo2 in DPA neurons by in situ hybridization, single-cell reverse transcriptase polymerase chain reaction, and whole-cell patch-clamp recordings. DPA neurons with Piezo2 messenger RNA (mRNA) or Piezo2-like currents were further characterized based on their neurochemical and electrophysiological properties. Piezo2 mRNA was found mostly in mediumto large-sized DPA neurons, with the majority of these neurons also positive for Nav1.8, CGRP, and NF200, whereas only a minor population was positive for IB 4 and peripherin. Whole-cell patch-clamp recordings revealed Piezo2-like, RI currents evoked by mechanical stimulation in a subpopulation of DPA neurons. RI currents were pharmacologically blocked by ruthenium red, a compound known to block Piezo2, and were also reduced by small interfering RNAmediated Piezo2 knockdown. Piezo2-like currents were observed almost exclusively in IB 4 -negative DPA neurons, with the current amplitude larger in capsaicin-insensitive DPA neurons than the capsaicin-sensitive population. Our findings show that subpopulation of DPA neurons is indeed mechanically sensitive. Within this subpopulation of mechanosensitive DPA neurons, we have identified the Piezo2 ion channel as a potential transducer for mechanical stimuli, contributing to RI inward currents. Piezo2-positive DPA neurons were characterized as mediumto large-sized neurons with myelinated A-fibers, containing nociceptive peptidergic neurotransmitters.
Betriebsräte und alternative Formen der Mitbestimmung: Ergebnisse aus dem IW-Zukunftspanel

Betriebliche Mitbestimmung wird hierzulande in der Regel mit der Interessenvertretung der Beschaftigten auf Basis des Betriebsverfassungsgesetzes gleichgesetzt. Eine Befragung von Unternehmen im Rahmen des IW-Zukunftspanels zeigt, dass in der Industrie und deren Verbundbranchen in gut 11 Prozent der Unternehmen ein Betriebsrat existiert. Dagegen finden sich freiwillig eingerichtete alternative Partizipationsformen an Informations- und Entscheidungsprozessen in doppelt so vielen Unternehmen. Ein fehlender Betriebsrat darf daher nicht mit einer mitbestimmungsfreien Zone verwechselt werden. Wahrend mit steigender Betriebsgrose die Verbreitung von Interessenvertretungen auf Basis des Betriebsverfassungsgesetzes kontinuierlich zunimmt, finden sich alternative Gremien, in denen Arbeitgeber und Mitarbeiter gemeinsam beraten und Entscheidungen treffen, vor allem in Unternehmen mit bis zu 100 Beschaftigten. Belegschaftssprecher, Mitarbeiterausschusse und sonstige Vertretungsformen auf Arbeitnehmerseite existieren hingegen haufig in Unternehmen mit 101 bis 199 Mitarbeitern. Mitbestimmungsorgane abseits der Betriebsverfassung gehen haufiger einher mit der Einfuhrung von leistungs- und erfolgsorientierten Lohnsystemen, in die die Mehrheit der Belegschaft eingebunden ist. Betriebsrate scheinen hingegen diesen breiten variablen Vergutungsmodellen eher ablehnend gegenuberzustehen.
CHOOSING AMONG COMPETING ENVIRONMENTAL AND LABOR STANDARDS: AN EXPLORATORY ANALYSIS OF PRODUCER ADOPTION 1

There has been a proliferation of environmental and labor certifications, such as Fair Trade, Rainforest Alliance, and SA 8000. This phenomenon is observed in many industries, including coffee, tourism, apparel, aquaculture, and electronics. Although these programs can have important social and environmental impacts (especially in developing countries, where institutions are weak and governments often do not have enough resources to enforce regulation), the effects of having multiple certification programs competing in an industry are not yet understood. Certification programs have been studied as a mechanism for producers to communicate unobservable organizational attributes to exchange parties. Such signals convey information about a producer’s environmental and labor practices, allowing buyers/consumers to factor them into their purchasing decisions. Previous research on self-regulation has focused on whether firms adopt a single certification. This paper explores what happens in industries in which multiple environmental and labor certifications are available to producers. I extend our understanding of self-regulation by analyzing how managers choose among various certification programs with different characteristics and deployed via different strategies. The empirical context of this paper is the flower industry in Colombia and Ecuador, two of the most important flower growers in the world. I use a combination of fieldwork and quantitative analysis of a unique dataset on flower exporters in these two countries. This exploratory analysis suggests that signaling theory might not suffice to explain producers’ certification choice. Other characteristics, such as the certifying organizations’ promotion strategies and firms’ social connections, seem to influence producers’ decisions. Results suggest that industries with competing certification programs might face a “race to the bottom,” where certifying organizations decrease the stringency of their standard and focus their efforts on marketing in order to increase their adoption by firms. This unanticipated outcome is, in part, a result of consumers being unable to distinguish between the certifications in terms of quality.
CATACGCCATCACC GGTTGTAGTAGCCTTG CTTCTTGTGCAGTG TGCAGCGAACTTTATT ATCCAGTGCAGGGTCCGAGGTATTCGCACTGGATACGACTCAACA GGTAGCTTATCAGACTG TGCAGGGTCCGAGG ATCCAGTGCAGGGTCCGAGGTATTCGCACTGGATACGACGGCTGT GGCTGACCTATGAATTG TGCAGGGTCCGAGG ATCCAGTGCAGGGTCCGAGGTATTCGCACTGGATACGACCTGTTC GGTGGCTCAGTTCAGCAG TGCAGGGTCCGAG

http://dx.doi. org/10.1016/j.jfma. 201 0929-6646/Copyright a 2015, Elsevier Background/purpose: Understanding the mechanisms of protecting the kidneys from injury is of great importance because there are no effective therapies that promote repair and the kidneys frequently do not repair adequately. Evidence has shown that erythropoietin (EPO) has a vital renoprotective role, independent of its erythropoietic effect. However, whether EPO can contribute to kidney repair after injury and the potential mechanisms are not fully understood. Methods: To investigate the renoprotective mechanism of EPO, a kidney ischemia/reperfusion injury (IRI) model was induced in adult male SpragueeDawley rats. The rats were subsequently randomly treated with EPO or a vehicle 6 hours after the kidney IRI. The rats were sacrificed on Day 3, Day 5, and Day 7 post kidney IRI. Renal function and histological alterations were examined. Renal interstitial macrophage infiltration, cell proliferation, apoptosis, and angiogenesis were evaluated by immunostaining. Furthermore, the effects of EPO on the Wnt/b-catenin pathway and IRI-related micro-RNAs were investigated. Results: The administration of EPO significantly improved renal function and reduced tubular injury. Furthermore, EPO treatment significantly prevented tubular cell apoptosis and promoted cell proliferation after IRI. Erythropoietin significantly suppressed macrophage infiltration, compared to the vehicle. In addition, treatment with EPO markedly prevented the loss of microvasculature. We have also demonstrated that, compared to the vehicle, EPO administration enhanced the expression of Wnt7b and b-catenin, and downregulated miR-21, -214, -210, and -199a.
Impact of Parental Interference on Children in High Conflict Divorce

Parental interference in high conflict divorce cases continues to evoke much debate among mental health professionals in the forensic psychology field. Although over the past thirty years, some empirical studies have been conducted regarding the long-term psychological impact of adults that experienced parental interference as children, few studies have examined the impact that this phenomenon has on children during and immediately following divorce proceedings. The present study utilized an original data set that was collected with fifty-five families (e.g., mother, father, and oldest child) from de-identified reports completed by two private Court-appointed licensed clinical-forensic psychologists. The overarching purpose of the present study was to gain further insight into identifying the impact that parental interference had on the psychological functioning within the identified sample. Moreover, the first purpose of this paper sought to highlight the specific domains that children and adolescents are negatively affected by as a result of parental interference within the present sample. Overall, results yielded no significant differences between groups regarding reported (self, teacher, and parent report) elevations on BASC-2 outcomes for children and adolescents. However, the results of a step-wise regression analysis suggested that female children and adolescents were more
KEY POINTS Chronic low-dose macrolide therapy in patients with NCFB has resulted in improved quality of life and a decreased exacerbation rate in several randomized controlled trials

Purpose of review Patients with noncystic fibrosis bronchiectasis (NCFB) share many of the respiratory symptoms of cystic fibrosis and often are provided therapies effective in cystic fibrosis, often without clear evidence of benefit. There are currently no approved therapies for NCFB, but in recent years, there has been increased interest in developing new therapies due to the increasing prevalence and perceived unmet needs. This review is meant to provide the most recent information to clinicians about currently available and pipeline therapies for NCFB.
Title : Seed origin and warming constrain lodgepole pine recruitment , slowing the pace of population range shifts Running head : Provenance and warming limit pine populations

Understanding how climate warming will affect the demographic rates of different ecotypes is critical to predicting shifts in species distributions. Here we present results from a common garden, climate change experiment in which we measured seedling recruitment of lodgepole pine, a widespread North American conifer that is also planted globally. Seeds from a low-elevation provenance had greater recruitment to their third year (by 323%) than seeds from a high-elevation provenance across sites within and above its native elevation range and across climate manipulations. Heating reduced (by 49%) recruitment to the third year of both low-and high-elevation seed sources across the elevation gradient, while watering alleviated some of the negative effects of heating (108% increase in watered plots). Demographic models based on recruitment data from the climate manipulations and long-term observations of adult populations revealed that heating could effectively halt modeled upslope range expansion except when combined with watering. Simulating fire and rapid post-fire forest recovery at lower elevations accelerated lodgepole pine expansion into the alpine, but did not alter final abundance rankings among climate scenarios. Regardless of climate scenario, greater recruitment of low-elevation seeds compensated for longer dispersal distances to treeline, assuming colonization was allowed to proceed over multiple centuries. Our results show that ecotypes from lower elevations within a species’ range could enhance recruitment and facilitate upslope range shifts with climate change.
Impact of intake boundary layer turbulence on the combustion behavior in a scramjet

The present investigations focus on the mixing and combustion enhancement capabilities of a boundary layer entering a combustion chamber. Numerical investigations for both a generic configuration and a real ramp compression intake of a full-scale vehicle with a combustion chamber height of 0.3 m were performed. The flow condition is chosen according to possible conditions in a scramjet combustion chamber with 1300-kelvin static temperature, 1-bar static pressure, and a Mach number of 3. The results of this sensitivity study show that both mixing and combustion efficiency are significantly increased due to the turbulence of the incoming boundary layer, whereas the required injector spacing to reach optimum mixing and combustion has to be increased. In addition to the classical porthole injection, an injection system with hypermixing capabilities was investigated which showed comparable sensitivities.
Investigating the Perceived Innovation Attributes, Toward Online Shopping in Malaysia

At this era of Internet, our daily lives are increasingly overshadowed by information technologies (ITs), when most of us are engaged in Internet shopping as a daily activity. Despite of a huge body of studies well done in developed countries; just few researches have been conducted on cognitive factors affecting consumer online shopping behaviour in developing countries context. The study intended to consider the result of the perceived attributes of innovation namely compatibility, relative advantage and complexity on Internet’ use of online shopping and subjective norm. To do this, structural equation modelling was employed to investigate the causal relationships between perceived attributes of innovation, the attitude of user toward using online purchasing. The result of analysis on a total 375 student samples revealed that relative advantage, compatibility and subjective norms significantly affect the attitude toward using online shopping, while regarding complexity the effect was not significant.
BIONOMICS, POPULATION DYNAMICS AND MANAGEMENT OF Uroleucon compositae (Theobald) INFESTING Gaillardia pulchella (Foug)

Investigations on bionomics, population dynamics and management of Uroleucon compositae (Theobald) infesting ornamental crop Gaillardia puchella Foug. were carried out at B.A. College of Agriculture, Anand Agricultural University, Anand during the year 2003-04. Of the plant floras surveyed for host range of U. compositae four ornamental crops (gaillardia, chrysanthemum, marigold and dahalia) one oil seed crop (safflower) and a weed (Euphorbia pilulifera L.) were found as hosts of this pest in middle Gujarat region. Both nymphs and adults of U. compositae sucked the cell sap from corolla, calyx, flowers, stalk, main stem and leaves of gaillardia. Infestation leads to development of black sooty mould resulting in to bad flower opening or poor quality of flowers. Severely infested plants withered and dried. The aphid passed through four nymphal instars. The first instar nymph was wingless, elongated and brownish or reddish in colour. As the nymph grew, colour changed from pale brown to dark brown. The colour of the adult was
Biochemical Alterations of Liver Enzymes and Microelements During Leishmania Major Infection in Balb/C Mice after Treatment with Paromomycin

Summary Cutaneous leishmaniasis (CL) is a zoonotic disease caused by Leishmania parasites. CL is still one of the health problems in tropical areas and in Iran. In this study, the Paromomycin was used for treatment of CL in Balb/c mice infected with Leishmania major. It is purposed that Paromomycin can be used as an appropriate achievement for control and therapy of CL. Paromomycin was used to inhibit leishmaniasis in susceptible Balb/c mice infected with Leishmania major MRHO/IR/75/ER; as a prevalent strain of CL in Iran. Serum concentrations of essential trace elements including copper (Cu) and Zinc (Zn) were determined by Flame Atomic Absorption Spectrophotometer (FAAS). Moreover, liver enzymes including Serum Glutamic Oxaloacetic Transaminase (SGOT), Serum Glutamic Pyruvic Transaminase (SGPT) and Alkaline Phosphatase (ALP) were also studied by Auto Analyzer Technical RA1000. Paromomycin therapy caused significant changes in the values of liver enzymes, Zn, Cu and Cu/Zn ratio as observed in healthy and infected Balb/c mice. Although, SGOT, SGPT and Cu were decreased in test groups, Zn and ALP increased in same groups in comparison with controls in healthy and infected groups of mice. The biochemical alteration of trace elements and liver enzymes was indicated during this study, which may attributable to anti-leishmanial effects of Paromomycin injection during L. major infection. This result clarifies Paromomycin as an effective therapy for the treatment of CL in rodent model of leishmaniasis.
Is the Government to Blame? An Experimental Test of How Partisanship Shapes Perceptions of Performance and Responsibility

The idea that voters use elections to hold governments to account for their performance lies at the heart of democratic theory, and countless studies have shown that economic performance can predict support for incumbents. Nonetheless recent work has challenged this simple link between policy performance and party choice by arguing that any relationship is conditioned by prior political beliefs, notably partisanship. Some have argued that economic perceptions are shaped by party choice rather than vice versa. Others have claimed that voters tend to attribute responsibility for perceived successes to their favored party, but absolve them of responsibility if performance is poor. This study examines the effect of partisanship on both performance evaluations and responsibility attributions using survey experiments to disentangle the complex causal relationships. Our findings show that partisan loyalties have pervasive effects on responsibility attributions, but somewhat weaker effects on evaluations of perfo.