Miracle-dz/UniFAR-FTUs huggingface dataset:
Psychiatric disorder, impairment, and service use in rural African American and white youth.

BACKGROUND The Caring for Children in the Community Study examined the prevalence of DSM-IV psychiatric disorders and correlates of mental health service use in rural African American and white youth. METHODS Four thousand five hundred youth aged 9 to 17 years from 4 North Carolina counties were randomly selected from school databases. Parents completed telephone questionnaires about their children's behavior problems. A second-stage sample of 1302 was identified for recruitment into the interview phase of the study, and 920 (70.7%) of these were successfully interviewed at home using the Child and Adolescent Psychiatric Assessment and related measures of service use. RESULTS Weighted back to general population estimates, 21.1% of youth had 1 or more DSM-IV psychiatric disorders in the past 3 months. Prevalence was similar in African American (20.5%) and white (21.9%) youth. The only ethnic difference was an excess of depressive disorders in white youth (4.6% vs 1.4%). Thirteen percent of participants (36.0% of those with a diagnosis) received mental health care in the past 3 months. White youth were more likely than African American youth to use specialty mental health services (6.1% vs 3.2%), but services provided by schools showed very little ethnic disparity (8.6% vs 9.2%). The effect of children's symptoms on their parents was the strongest correlate of specialty mental health care. CONCLUSIONS In this rural sample, African American and white youth were equally likely to have psychiatric disorders, but African Americans were less likely to use specialty mental health services. School services provided care to the largest number of youths of both ethnic groups.
The Paradox of Managerial Dividend Policy in Corporate Malaysia

The prime objective of this paper is to survey the managers of Bursa Malaysia listed non-financial firms and to divulge their views regarding the significance of various potential factors that may affect dividend decisions. In addition to that, we are also interested in highlighting that how managerial perception about the importance of these factors varies from country to country. Our next objective is to know the level of importance, Malaysian managers give to dividend processes and pattern, firm value. Dividend policy (DP) and residual dividend policy (RDP). Finally, we are interested in measuring the level of support that Malaysian managers provide for different justifications for the payment of dividends. Survey instrument including a cover letter was mailed to chief finance officers (CFO) and finance managers of 493 Bursa Malaysia listed firms in October 2017. In the cover letter, a request was made to all respondents that in case of their non-involvement in dividend decision the letter must be forwarded to concerned authority involved in dividend decisions. The response rate of the current study is 40.09 percent (202 out of 493 firms). The study has used a mail survey of Bursa Malaysia listed non-financial firms that have paid at least one cash dividend during the period of 2013-2016 as a primary means of collecting data. No single pattern in rankings of factors among different countries has emerged. However, like their American, Canadian and Indonesian counterparts, According to Malaysian managers, dividend decisions have a significant effect on firm value. Although, a great deal of support has already been established with all dividend theories, however clientele and agency theory has proven to be the strongest one. In author’s knowledge, this is the first study designed to explore the views of Malaysian managers on DP in Malaysia.
Corruption of Human Follicular B-Lymphocyte Trafficking by a B-Cell Superantigen

Protein A (SpA) of Staphylococcus aureus is known to target the paratope of immunoglobulins expressing VH3 genes, and to delete marginal zone B cells and B-1a in vivo. We have discovered that SpA endows S. aureus with the potential to subvert B-cell trafficking in the host. We found that SpA, whose Fc-binding site has been inactivated, binds essentially to naïve B cells and induces a long-lasting decrease in CXCR4 expression and in B-cell chemotaxis to CXCL12. Competition experiments indicated that SpA does not interfere with binding of CXCR4 ligands and does not directly bind to CXCR4. This conclusion is strongly supported by the inability of SpA to modulate clathrin-mediated CXCR4 internalization, which contrasts with the potent effect of anti-immunoglobin M (IgM) antibodies. Microscopy and biochemical experiments confirmed that SpA binds to the surface IgM/IgD complex and induces its clathrin-dependent internalization. Concomitantly, the SpA-induced signaling leads to protein kinase C-dependent CXCR4 downmodulation, suggesting that SpA impairs the recycling of CXCR4, a postclathrin process that leads to either degradation into lysozomes or de novo expression at the cell surface. In addition to providing novel insight into disruption of B-cell trafficking by an infectious agent, our findings may have therapeutic implications. Because CXCR4 has been associated with cancer metastasis and with certain autoimmune diseases, SpA behaves as an evolutionary tailored highly specific, chemokine receptor inhibitor that may have value in addition to conventional cytotoxic therapy in patients with various malignancies and immune-mediated diseases.
Identification of Novel Susceptibility Loci for Kawasaki Disease in a Han Chinese Population by a Genome-Wide Association Study

Kawasaki disease (KD) is an acute systemic vasculitis syndrome that primarily affects infants and young children. Its etiology is unknown; however, epidemiological findings suggest that genetic predisposition underlies disease susceptibility. Taiwan has the third-highest incidence of KD in the world, after Japan and Korea. To investigate novel mechanisms that might predispose individuals to KD, we conducted a genome-wide association study (GWAS) in 250 KD patients and 446 controls in a Han Chinese population residing in Taiwan, and further validated our findings in an independent Han Chinese cohort of 208 cases and 366 controls. The most strongly associated single-nucleotide polymorphisms (SNPs) detected in the joint analysis corresponded to three novel loci. Among these KD-associated SNPs three were close to the COPB2 (coatomer protein complex beta-2 subunit) gene: rs1873668 (p = 9.52×10−5), rs4243399 (p = 9.93×10−5), and rs16849083 (p = 9.93×10−5). We also identified a SNP in the intronic region of the ERAP1 (endoplasmic reticulum amino peptidase 1) gene (rs149481, pbest = 4.61×10−5). Six SNPs (rs17113284, rs8005468, rs10129255, rs2007467, rs10150241, and rs12590667) clustered in an area containing immunoglobulin heavy chain variable regions genes, with pbest-values between 2.08×10−5 and 8.93×10−6, were also identified. This is the first KD GWAS performed in a Han Chinese population. The novel KD candidates we identified have been implicated in T cell receptor signaling, regulation of proinflammatory cytokines, as well as antibody-mediated immune responses. These findings may lead to a better understanding of the underlying molecular pathogenesis of KD.
The influence of sociodemographic characteristics on health care utilisation in a Swedish municipality

During recent years there has been a debate on factors that might influence health care utilisation, and the possibilities to predict such utilisation in order to facilitate the allocation of health care resources in the community. Currently only the age distribution in the population is usually used for such predictions. In this study the influence of a number of other sociodemographic characteristics on health care utilisation, in addition to age and sex, was assess in a small Swedish community. A postal questionnaire, containing questions on health care utilisation and a number of sociodemographic factors, was sent to a random, stratified sample of the population of Habo municipality, Sweden. Out of the sampled 1312 subjects, 827 (63%) responded to the questionnaire. Subjects aged 65 years and above had higher odds for having consulted a physician, having been hospitalised and having a cost limitation card compared to those below age 65. Men had significantly lower odds than women for having consulted a physician, having visited other health care providers and having a cost limitation card. Singles, as compared to married subjects, had lower odds for all health care measures except having consulted a physician. Subjects with sick leave or disability pension, as compared to working subjects, had higher odds for most health care utilisation measures. A number of sociodemographic factors were thus associated with health care utilisation and might be considered in the health care resources allocation process.
Evidence for functional NK1‐tachykinin receptors on motor neurones supplying the circular muscle of guinea‐pig small and large intestine

The guinea‐pig intestine was investigated to determine which neurones are excited via NK1 receptors. The specific NK1 receptor agonists [Sar9, Met(O2)11]‐SP and septide contracted the circular muscle of all regions via a tetrodotoxin (TTX)‐insensitive mechanism. In the proximal colon, they also evoked a TTX‐sensitive relaxation; in the distal colon, the contractions were larger when nerve impulses were blocked with TTX, indicating that the agonists excited inhibitory motor neurones. In the duodenum and ileum, TTX reduced agonist‐evoked contractions indicating that excitatory motor neurones were activated. In the presence of indomethacin, TTX enhanced contractions of ileal circular muscle evoked by these agonists suggesting that NK1 receptors were on inhibitory motor neurones. Blockade of nitric oxide synthase (NOS) enhanced NK1 receptor agonist evoked contractions of duodenal circular muscle, indicating that the agonists excite inhibitory motor neurones in duodenum. Neurones immunoreactive for NK1 receptors were studied in the duodenum and distal colon. As reported previously for the ileum, 1 some neurones were immunoreactive for NOS and had Dogiel type I morphology; features characteristic of inhibitory motor neurones. In conclusion, there are functional NK1 receptors on excitatory and inhibitory motor neurones in the guinea‐pig small intestine and on inhibitory motor neurones in the colon.
Immunoglobulins in normal infant born of severe hypo-gamma-globulinaemic mother.

Delayed hypersensitivity to dinitrochlorobenzene (DNCB) was induced at the age of 13 months by applying 2 mg in acetone to a 1 cm2 area of the forearm. No delayed reaction followed, and no reaction was provoked by the application of a further dose of 0 02 mg 2 weeks later; but a third dose of 0 * 04 mg at the age of 14 months produced a normal delayed hypersensitivity reaction, with a wheal and vesicles. He was still positive at the age of 4j years with a 0 05 mg dose, when a weak delayed reaction to candida 0 10% was also shown. Antibody was not detected to herpes simplex, cytomegalovirus, or rubella at the age of 14months. One month after measles inoculation the titre of measles antibody was 1/64, at 26 months of age.
Oral administration of formalin-inactivated cells of Aeromonas hydrophila A3-51 controls infection by atypical A. salmonicida in goldfish, Carassius auratus (L.).

There has been increasing interest in the use of probiotics in aquaculture to control fish diseases (e.g. Douillet Langdon 1994; Gildberg, Mikkelsen, Sandaker & Ringo 1997; Kennedy, Tucker, Neidic, Vermeer, Cooper, Jarrell & Sennett 1998; DeSchrijver & Ollevier 2000; Robertson, O'Dowd, Burrells, Williams & Austin 2000), and a diverse range of Gram-positive (such as Carnobacterium inhibens) (Robertson et al. 2000) and Gram-negative bacteria, including Vibrio alginolyticus (Garriques & Arevalo 1995), have been evaluated at various times. However, the possible use of probiotics to control diseases of ornamental fish has been neglected. Consequently, following previous success with live (Irianto & Austin 2002) and inactivated probiotics in salmonids (Irianto & Austin, in press), research has focused on the usefulness of inactivated bacterial preparations for the control of atypical Aeromonas salmonicida infections in goldfish, Carassius auratus (L.). Goldfish, of average 40-50 mm in length, were obtained from a commercial farm in England, and maintained in aerated re-circulating dechlorinated fresh water at 17 degrees C. Their health status was examined immediately upon arrival in the aquaria and at 1-2-week periods thereafter (after Austin & Austin 1989).
Variation in fibrinogen FGG and FGA genes and risk of stroke

Summary Haplotypes of the fibrinogen gamma and alpha (FGG and FGA) genes are associated with the structure of the fibrin network and may therefore influence the risk of stroke. We investigated the relationship between common variation in these genes with ischemic and haemorrhagic stroke. The study was based on 6,275 participants of the prospective population-based Rotterdam Study who at baseline (1990 – 1993) were aged 55 years or over, free from stroke, and had successful assessment of at least one FGG or FGA single nucleotide polymorphisms (SNP). Common haplotypes were estimated using seven tagging SNPs across a 30 kb region containing the FGG and FGA genes. Follow-up for incident stroke was complete until January 1,2005. Associations between constructed haplotypes and risk of stroke were estimated with an age- and sex-adjusted logistic regression model. We observed 668 strokes, of which 393 were ischemic and 62 haemorrhagic, during a median follow-up time of 10.1 years. FGG+FGA haplotype 3 (H3) was associated with an increased risk of ischemic stroke (odds ratio [OR] 1.36, 95% confidence interval [CI] 1.09–1.69) and the risk estimate for hemorrhagic stroke was 0.71 (95% CI 0.46–1.09) compared to the most frequent H1. The FGG and FGA genes were not associated with stroke or its subtypes when analyzed separately. In conclusion, risk of ischemic stroke was higher in FGG+FGA H3 than in H1. The results suggested that an opposite association may exist for haemorrhagic stroke.
Clitorodynia: A Descriptive Study of Clitoral Pain.

INTRODUCTION Clitorodynia is classified as a type of localized vulvodynia. Our knowledge of this problem is limited to case studies and one published report. AIMS The objective of the present study was to describe quantitatively the clinical characteristics of clitoral pain, to assess interference with sexual function, and to investigate whether clitoral pain is a unitary category. METHODS One hundred twenty-six women with clitoral pain completed an online questionnaire that assessed demographic information, descriptive pain characteristics, intensity and impact on daily activities, sexual function, and gynecological and medical histories. MAIN OUTCOME MEASURES The main outcome measures used for the study are the following: clitoral pain characteristics (e.g., intensity, duration, quality, distress, etc.), short-form McGill pain questionnaire-2, and the female sexual function index. RESULTS Clitoral pain is characterized by frequent and intense pain episodes that can either be provoked or unprovoked, and causes significant impairment in both daily and sexual function. The pain can be localized to the clitoris only or can occur with other genital pain. Comorbidity with other chronic pain disorders is common. A cluster analysis suggested two distinct patterns of clitoral pain, one localized and one generalized. CONCLUSION Our findings indicate that women with clitoral pain suffer from significant, distressing, and often long-term pain, which interferes with sexual and daily activities. Two subtypes of clitoral pain may exist, each with distinct pain characteristics and subjective experiences.
Hepatic resection for metastatic tumours from gastric cancer: Analysis of prognostic factors

Determinants of prognosis after hepatic resection for metastasis from gastric cancer were studied in a retrospective series of 21 patients, including four who survived more than 5 years after surgery. All patients underwent apparently curative resection. Synchronous or metachronous resection, age, sex, histological type, depth of invasion, lymphatic and venous invasion, lymph node involvement and number of hepatic metastases were analysed as prognostic factors for survival. Serosal invasion was the only significant determinant at synchronous resection. Both lymphatic and venous invasion were significant prognostic factors available after histological examination. Combined analysis of these two histological variables revealed that patients positive for both were at a significantly higher risk for both overall and disease‐free survival. It is suggested that hepatic resection should be attempted in patients with synchronous or metachronous metastases if there is no serosal invasion by the primary gastric tumour, and if the primary tumour has neither venous nor lymphatic invasion in the case of metachronous metastases.
Novel Hospital Curtains with Antimicrobial Properties: A Randomized, Controlled Trial

Design. Privacy curtains that separate patient care areas in hospitals may play an important role in the transmission of healthcare-associated pathogens. The aim of this randomized, controlled trial was to assess the effectiveness in a clinical setting of curtains incorporating a complex element compound (CEC) with antimicrobial properties. Setting. Twenty-one rooms in a surgical intensive care unit (ICU) and 9 rooms in a medical ICU were randomly selected to receive either a new standard curtain or a new identical-looking CEC curtain. Fifteen rooms received CEC curtains and 15 received standard curtains. Methods. Cultures were performed of samples that were collected from curtains twice a week for 4 weeks (23 days). Contamination was determined according to standard microbiologic methods. Time to contamination was assessed with the Wilcoxon rank-sum test and survival analysis. Incidence rates of contamination were compared using Poisson regression. Results. The median time to first contamination was 7 times longer for CEC curtains than for standard curtains (14 vs 2 days; P< .01). CEC curtains were significantly less contaminated than standard curtains according to earlier culture results but not significantly different for later culture results. Fourteen CEC curtains and 13 standard curtains were contaminated at least once (P = 1.0). The adjusted rate of contamination was 29% lower among CEC versus standard curtains, but this was not statistically significant (rate ratio, 0.71; 95% CI, 0.48–1.07). Conclusions. CEC privacy curtains increase the time to first contamination as compared with standard curtains. Use of privacy curtains with antimicrobial properties could increase the time between washings and may potentially play a role in decreasing pathogen transmission.
Validation of an Adaptation of Levenson’s Locus of Control Scale With Adult Male Incarcerated Sexual Offenders

This article examines the psychometric properties of an adaptation of Levenson’s Locus of Control (LoC) measure that is used by the English and Welsh Prison Service as part of the psychometric assessment battery for sexual offenders participating in the Sex Offender Treatment Programme (SOTP). Reliability and validity analyses were conducted on a sample of 2,497 sexual offenders who had completed SOTP. Internal consistency, convergent validity, and relationship to socially desirable responding were investigated. Construct validity was assessed via exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). Test-retest reliability data were collected from an additional sample of 26 sexual offenders. The scale was found to have excellent internal consistency, good test-retest reliability, and weak to moderate convergent validity with measures of self-esteem, attachment styles, emotional loneliness, and social problem solving. There was a moderate correlation between the scale and socially desirable responding. EFA and CFA suggested that a four-factor solution provided an acceptable fit to the data, with the factors relating to constructs of chance, problem solving, powerful others, and internal control. The findings of the present study suggest that the adapted LoC Scale is a useful tool for assessing sexual offenders’ locus of control.
Suppressible and nonsuppressible +1 G-C base pair insertions induced by ICR-170 at the his4 locus in Saccharomyces cerevisiae

Fifteen independent ICR-170-induced his4 mutations in Saccharomyces cerevisiae were examined by DNA sequence analysis. All of the mutations contained a +1 G-C base pair addition in the HIS4 coding region. Eleven different sites of insertion were identified. Combined with previous DNA sequence data, 21 ICR-170-induced his4 mutations distributed at 16 different sites were analyzed. The insertions were always located in a consecutive run of two or more G-C base pairs, with all base pairs in each run having identical orientation. Long consecutive G-C runs were preferred target sites over short runs. Although some consecutive G-C runs appeared to be preferred target sites over others of identical length, such preference was not due to any particular type of nucleotide pair immediately adjacent to a given target site. In addition, DNA sequence analyses of the his4 mutations provided a basis for examining the mechanism of mRNA sequence recognition by extragenic suppressors of ICR-170-induced mutations. The implications of these results for mechanisms of frameshift suppression are discussed.
Effects of Ovariectomy and Prolactin on Mammary Gland Expressions of Transforming Growth Factor α and Epidermal Growth Factor Receptor mRNAs in Mice

Abstract Beginning 15 days after ovariectomy (OVX), a high mammary tumor strain of SHN virgin mice at 3 months of age received subcutaneous injections of danazol (0.5 μg / 0.1 ml olive oil, once a day), perphenazine (0.05 mg / 0.1 ml saline, twice a day) or ovine prolactin (oPRL: 0.25 mg / 0.05 ml buffer, twice a day) for 3 days to modulate their circulating PRL levels. The serum PRL level was significantly decreased by danazol and increased by perphenazine compared to the intact and OVX-control groups. The expression of both transforming growth factor α (TGFα) mRNA and epidermal growth factor receptor (EGFR) mRNA in the mammary gland was increased by danazol. However, TGFα mRNA expression was decreased by perphenazine. Meanwhile, mammary end-bud formation was inhibited in danazol-treated group. All findings suggest that the manifestation of the effect of TGFα on mammary gland is rather suppressed by PRL, while mammary gland growth needs the participation of PRL; in other words, PRL is dominant to TGFα on the mammary gland growth. OVX resulted in a significant decrease of TGFα mRNA expression in the mammary gland despite of little alteration in serum PRL, confirming the previous observations. The similar trend was observed in ICR mice; however, the response to hormonal modulation is generally less susceptible than SHN mice.