Miracle-dz/UniFAR-FTUs huggingface dataset:
[Management of postoperative inflammatory response and pain with nimesulide after cardiac surgery].

INTRODUCTION Nimesulid (Mesulid) is a non-steroid anti-inflammatory drug (NSAID), acting by the selective inhibition of the Cyclooxygenase-2 (COX-2) isoenzyme. In this study the efficacy of nimesulid following cardiac surgery has been investigated in comparison with that of a COX-1 isoenzyme inhibitor drug. PATIENTS AND METHODS 200 cardiac surgical patients operated on cardiopulmonary bypass have been involved in this prospective study. 100 patients received 100 mg. nimesulid bd. routinely in the postoperative period (group M). Another 100 patients were given 275 mg naproxen bd. (group A). In both groups the White Blood Cell (WBC), the blood sedimentation (We), the C-Reactive Protein (CRP) levels were determined from venous blood samples before the operation and on the first five postoperative days. Venous blood samples of 20 patients of each group in the same period were used to determine the Interleukin-6 (IL-6), and the Soluble Tumour Necrosis Factor Receptor-I (sTNF-RI) levels. Postoperative complications related to the use of the investigated drugs as well as the side effects have been compared in the two groups. A visual analogue pain scale was used before and after drug administration. Kruskal Wallis and student t tests were used for the statistical analysis. RESULTS No serious complication related to the use of the investigated drugs has developed in either group. In group A gastrointestinal side effect were recorded in 7 cases (7%) whilst in group M no such complaints were found. Drug doses defined in the study protocol had to be raised or another drug had to be added in 11 and 3 cases in group A and M respectively. Neither the laboratory findings, nor the visual pain scale results have not shown any significant difference between the groups. CONCLUSION The efficacy of nimesulid in postoperative inflammatory inhibition and pain relief has proved equal to that of the investigated COX-1 inhibitor drug, however less gastrointestinal side effects have been related to its administration.
A Novel Iterative and Dynamic Trust Computing Model for Large Scaled P2P Networks

Trust management has been emerging as an essential complementary part to security mechanisms of P2P systems, and trustworthiness is one of the most important concepts driving decision making and establishing reliable relationships. Collusion attack is a main challenge to distributed P2P trust model. Large scaled P2P systems have typical features, such as large scaled data with rapid speed, and this paper presented an iterative and dynamic trust computation model named IDTrust (Iterative and Dynamic Trust model) according to these properties. First of all, a three-layered distributed trust communication architecture was presented in IDTrust so as to separate evidence collector and trust decision from P2P service. Then an iterative and dynamic trust computation method was presented to improve efficiency, where only latest evidences were enrolled during one iterative computation. On the basis of these, direct trust model, indirect trust model, and global trust model were presented with both explicit and implicit evidences. We consider multifactors in IDTrust model according to different malicious behaviors, such as similarity, successful transaction rate, and time decay factors. Simulations and analysis proved the rightness and efficiency of IDTrust against attacks with quick respond and sensitiveness during trust decision.
Id4 promotes senescence and sensitivity to doxorubicin-induced apoptosis in DU145 prostate cancer cells.

UNLABELLED Inhibitor of differentiation proteins (Id1, 2, 3 and 4) are dominant negative regulators of basic helix loop helix transcription factors and play dominant roles in cancer cells, spanning several molecular pathways including senescence, invasion, metastasis, proliferation and apoptosis. In contrast to high Id1, Id2 and Id3 expression, the expression of Id4 is epigenetically silenced in prostate cancer. In the present study we demonstrated a novel role of Id4, that of promotion of cellular senescence in prostate cancer cells. MATERIALS AND METHODS Id4 was ectopically expressed in DU145 cells (DU145+Id4). The cells treated with Doxorubicin (0-500 nm) or vehicle control were analyzed for apoptosis, senescence (SA-beta Galactosidase), and expression of CDKN1A (p21), CDKN1B(p27), CDKN2A (p16), E2F1, vimentin and E-cadherin by immuno-histochemistry and/or Western blot. RESULTS In the present study we demonstrated that Id4 promotes cellular senescence in prostate cancer cell line DU145. Ectopic overexpression of Id4 in androgen receptor-negative DU145 prostate cancer cells resulted in increased expression of p16, p21, p27, E-cadherin and vimentin but down-regulated E2F1 expression. Id4 also potentiated the effect of doxorubicin induced senescence and apoptosis. CONCLUSION The absence of functional p16, pRB and p53 in DU145 suggests that Id4 could alter additional molecular pathways such as those involving E2F1 to promote senescence and increased sensitivity to doxorubicin-induced apoptosis. The results of the present study support the role of Id4 as a tumor suppressor in prostate cancer.
The role of stress transactional theory on the development of fibromyalgia: a structural equation model.

INTRODUCTION The aim of this paper is to evaluate the efficacy of a model based on the Lazarus & Folkman's transactional theory of stress to explain perceived stress and symptoms in a sample of people with fibromyalgia. METHODS The design was an open, cross-sectional, uncontrolled study. Subjects were contacted through internet. A self-administered questionnaire was used that contained each of the variables included in the model. To perform the statistical analysis we used structural equation models. RESULTS We evaluated 165 people who reported to have fibromyalgia diagnosis, 93.9% were female. According to PHQ-15 categories, used to measure symptoms, 83% of the participants were in the highest level of somatic symptom severity. FIQ was used to evaluate fibromyalgia impact, its maximum score is 100 points; taking into account mean and standard deviation, the samples are severely affected by fibromyalgia. We estimated five structural models; fifth model confirmed that some personal and social resources (self-esteem, self-efficacy, social support) perform as predictors of perceived stress level explaining 53% of its variance. This perceived stress was predictor of a latent variable indicated by symptoms and FIQ, and it explained 31% of its variance. Goodness of fit index was adequate. CONCLUSIONS The study suggests the important role that perceived stress has in the fibromyalgia impact and the symptoms severity. This model can help to adequate and establish targets for the psychological treatments included in multidisciplinary programs for this disorder.
Electron traps and their effect on the surface chemistry of TiO2(110)

Oxygen vacancies on metal oxide surfaces have long been thought to play a key role in the surface chemistry. Such processes have been directly visualized in the case of the model photocatalyst surface TiO2(110) in reactions with water and molecular oxygen. These vacancies have been assumed to be neutral in calculations of the surface properties. However, by comparing experimental and simulated scanning tunneling microscopy images and spectra, we show that oxygen vacancies act as trapping centers and are negatively charged. We demonstrate that charging the defect significantly affects the reactivity by following the reaction of molecular oxygen with surface hydroxyl formed by water dissociation at the vacancies. Calculations with electronically charged hydroxyl favor a condensation reaction forming water and surface oxygen adatoms, in line with experimental observations. This contrasts with simulations using neutral hydroxyl where hydrogen peroxide is found to be the most stable product.
Catheter Access for Hemodialysis: An Overview

The provision of hemodialysis requires repeated, reliable access to the central circulatory system. Long‐term hemodialysis has best been provided by arteriovenous fistulae and arteriovenous grafts. In recent years, more and more patients have been chronically dialyzed with tunneled dialysis catheters. These catheters, which were originally developed as a short‐term bridge to permanent vascular access, have made up an increasing percentage of maintenance vascular access. While these catheters have the advantage of ease of placement and are immediately ready for use, they substantially increase the risk of bacteremia, stenosis of central veins, and even mortality.
Hurthle cell carcinoma

Hurthle cell carcinoma (HCC) is an uncommon and more aggressive thyroid cancer. To date, there is a paucity of data at a population level. In this study, demographic, clinical, and pathologic characteristics of HCC were investigated and compared with other types of differentiated thyroid cancers (ODTCs). The authors also evaluated disease‐specific survival and compliance with American Thyroid Association (ATA) management guidelines from 2009.
Eradication of Helicobacter pylori increases childhood growth and serum acylated ghrelin levels.

AIM To determine whether Helicobacter pylori (H. pylori)-infected children have reduced body weight (BW) and height (BH) growth, and if H. pylori eradication may restore growth while improving serum acylated ghrelin. METHODS This longitudinal cohort study with one-year follow-up enrolled 1222 children aged 4 to 12 years old into an observation cohort (18 with and 318 without H. pylori) and intervention cohort (75 with and 811 without). The 7-d triple therapy was used for eradication in the intervention cohort. The net increases of BW and BH as well serum acylated ghrelin after one-year follow-up were compared between successful eradicated H. pylori-infected children and controls. RESULTS In the observation cohort, the H. pylori-infected children had lower z score of BW (-1.11 ± 0.47 vs 0.35 ± 0.69, P = 0.01) and body mass index (BMI) (0.06 ± 0.45 vs 0.44 ± 0.73, P = 0.02) at enrollment and lower net BW gain after one-year follow-up (3.3 ± 2.1 kg vs 4.5 ± 2.4 kg, P = 0.04) than the non-infected controls. In the intervention cohort, the H. pylori-infected children had lower z score of BMI (0.25 ± 1.09 vs 0.68 ± 0.87, P = 0.009) and serum acylated ghrelin levels (41.8 ± 35.6 pg/mL vs 83.6 ± 24.2 pg/mL, P < 0.001) than the non-infected controls. In addition to restoring decreased serum ghrelin levels (87.7 ± 38.0 pg/mL vs 44.2 ± 39.0 pg/mL, P < 0.001), the H. pylori-infected children with successful eradication had higher net gains (P < 0.05) and increase of z scores (P < 0.05) of both BW and BH as compared with non-infected controls after one-year follow-up. CONCLUSION H. pylori-infected children are associated with low serum acylated ghrelin and growth retardation. Successful eradication of H. pylori restores ghrelin levels and increases growth in children.
Functional expression of A‐currents in embryonic chick sympathetic neurones during development in situ and in vitro.

1. The functional expression of transient voltage‐activated K+ currents (IA) was examined using whole‐cell recording techniques in embryonic chick sympathetic ganglion neurones that developed in situ and under various growth conditions in vitro. 2. The density of IA increased dramatically during development in sympathetic neurones isolated acutely between embryonic days 7 and 20 (E7‐E20). The time course of IA inactivation became significantly faster between E7 and E13. With these protocols, neuronal differentiation and development occurred entirely in situ. 3. Sympathetic neurones isolated at E9 and maintained in vitro for 4 days did not express a normal IA compared to neurones isolated acutely at E13. Those neurones that were in physical contact with other neurones expressed normal densities of IA, but the resulting inactivation kinetics were abnormally slow. Sympathetic neurones that were cultured on the membrane fragments of lysed neurones expressed normal densities of IA even when they failed to make visible connections with other viable neurones, but the resulting inactivation kinetics were abnormally slow. Those cultured neurones that were not in physical contact with other cells or their membranes had markedly reduced densities of IA with abnormally slow inactivation kinetics. 4. Application of 5‐100 ng ml‐12.5 S nerve growth factor by itself did not promote normal A density of kinetics in E9 sympathetic neurones cultured for 4 days. 5. Sympathetic neurones that developed in vitro in physical contact with ventral spinal cord explants, cardiac myocytes or aortic smooth muscle cells expressed normal densities of IA, but the inactivation kinetics were abnormally slow. Cell culture media conditioned by these tissues failed to promote normal IA expression. Sympathetic neurones cultured as explants or maintained under depolarizing conditions did not express a normal IA. 6. Embryonic chick sympathetic neurones exhibit developmental changes in the density and kinetics of IA that can be regulated independently by extrinsic environmental factors including interactions with insoluble components of the plasma membranes of some cells.
Stability and Structure of MgSiO3 Perovskite to 2300-Kilometer Depth in Earth's Mantle

Unexplained features have been observed seismically near the middle (∼1700-kilometer depth) and bottom of the Earth's lower mantle, and these could have important implications for the dynamics and evolution of the planet. (Mg,Fe)SiO3 perovskite is expected to be the dominant mineral in the deep mantle, but experimental results are discrepant regarding its stability and structure. Here we report in situ x-ray diffraction observations of (Mg,Fe)SiO3perovskite at conditions (50 to 106 gigapascals, 1600 to 2400 kelvin) close to a mantle geotherm from three different starting materials, (Mg0.9Fe0.1)SiO enstatite, MgSiO3glass, and an MgO+SiO2 mixture. Our results confirm the stability of (Mg,Fe)SiO3 perovskite to at least 2300-kilometer depth in the mantle. However, diffraction patterns above 83 gigapascals and 1700 kelvin (1900-kilometer depth) cannot presently rule out a possible transformation from Pbnm perovskite to one of three other possible perovskite structures with space groupP21/m, Pmmn, orP42/nmc.
Heinz-body Anaemia Due to Dapsone

of the heart, spontaneous beating recommenced, while blood pressure, pulse, skin colour, and pupils returned to normal. ft was then discussed whether or not operation should continue, and it was decided to proceed with the skin grafts. For adequate working function of the patient's hands and a good result for the face they must be grafted as soon as possible, as in a subsequent anaesthesia he might develop an irreversible cardiac arrest. The operation lasted two hours (including cardiac arrest) without further incident, and the patient awoke immediately after extubation. He made an uneventful recovery except for a transient pleural effusion, which was tapped under local analgesia without further recurrence. Electrocardiograms taken on March 23, 27, 28, and 30 were normal. The patient left hospital two weeks after the grafting. When seen three months later his hand function was fair, though he was still very anxious. Otherwise cerebral function was good. Later, operations were carried out seven times on the hands and face under local analgesia. On the hands the method used was brachial plexus block. There has been no further incident in connexion with these anaesthesias. When the patient was seen again one year and three months later, his anxiety was much less and the electrocardiogram continued to be normal.
Antibody-producing cell responses to an isolated outer membrane protein and to complexes of this antigen with lipopolysaccharide or with vesicles of phospholipids from Proteus mirabilis

Antibody-producing cell responses of mice to a protein isolated from the outer membrane of Proteus mirabilis were typical of the responses to a thymus-dependent antigen. The immunoglobulin G antibody-producing cell responses to the protein were increased after administration of the antigen complexed with either lipopolysaccharide or with vesicles of phospholipids extracted from P. mirabilis. The protein in turn significantly increased the immune response to lipopolysaccharide and also converted this response from predominantly immunoglobulin M to predominantly immunoglobulin G.
SWOV Fact sheet The relation between speed and crashes

The exact relation between speed and crashes depends on many factors. However, in a general sense the relation is very clear: if on a road the driven speeds become higher, the crash rate will also increase. The crash rate is also higher for an individual vehicle that drives at higher speed than the other traffic on that road. As speeds get higher, crashes also result in more serious injury, for the driver who caused the crash as well as for the crash opponent. The injury severity of the vehicle occupants in a crash, for example, is not only determined by the collision speed, but also by the mass difference between the vehicles and by the vulnerability of the vehicles/road users who are involved. In a crash between a light vehicle and a heavier one, the occupants of the lighter vehicle generally are considerably worse off than the occupants of the heavier vehicle. Even more so this is the case for pedestrians, cyclists and moped riders in crashes with (much) heavier motor vehicles.
Serum levels of EBVNA-IgG and EBVCA-IgG in patients with multiple sclerosis -

The present case-control study includes 50 patients with multiple sclerosis, diagnosed according to McDonald criteria, 35 women and 15 men, median age 40.8 years (21-61). Twenty of them had familial history with disease transmitted from the mother. Relapsing-remitting course was noted in 42 of them, relapsing-progressive in 4 and secondary progressive in 4. Statistically significant association with multiple sclerosis was found only for the highest serum levels of EBVCA IgG > 750 U/ml (17 vs. 8, p 1.000 U/ml (23 vs. 3, p750 U/ml и EBVNA > 1.000 U/ml, the entire cohort and controls. In contrast to the literature, we found no convincing evidence for the role of EBV in MS. Except a true association, the highest serum levels may reflect a synergistic influence of other genetic or enviromental factors or may be just a secondary phenomenon. However, the possible role of EBV at the early stages of MS pathogenesis could not be excluded and future and larger studies with a proper design are justified.
Eight years' experience of uterine rupture cases

Summary Ruptured uterus is a serious obstetric emergency with a high maternal and perinatal mortality. It is a preventable and common obstetric problem in developing countries. The objective of this study was to review the incidence, methods of diagnosis and maternal and perinatal morbidity and mortality associated with uterine rupture. Case notes were reviewed for all patients with a ruptured uterus at Yüzüncü Yıl University Medical Faculty Department of Obstetrics and Gynaecology from January 1995 to August 2003. Relevant data relating to the clinical characteristics of labour, operative procedures, maternal and perinatal outcome were assessed. There were 20 cases of ruptured uteri. The incidence was 0.40%. When patients referred from other hospitals were excluded, the revised ratio was 0.12%. There were 13 (65%) complete and seven (35%) incomplete ruptures. Nine (45%) cases occurred in patients with scarred uteri. Ten (50%) cases were grand multiparous. Subtotal abdominal hysterectomy was performed in five (25%) cases, total abdominal hysterectomy was performed in two (10%) cases and the remaining 13 (65%) cases had uterine rupture repair. There were two (10%) maternal deaths. Both of them were referred from other hospitals. There were seven (35%) perinatal deaths attributable to uterine rupture. Occurrence of uterine rupture is significantly associated with grand multiparity, scarred uterus, lack of antenatal care, unsupervised labour at home and low socioeconomic status of the patients. These factors are largely preventable.
Cigarette smoking and medical students at King Edward Medical University, Lahore (Pakistan).

OBJECTIVES To observe the frequency of cigarette smoking in medical students of King Edward Medical University and to determine associated variables. METHOD A cross-sectional survey was conducted and data was collected through a self administered questionnaire from students at King Edward Medical University. Information about demographic characteristics, smoking status in family, number of cigarettes smoked/day, influence for starting it and use of nicotine replacement therapy was obtained. Duration of study was from April 1 to May 30, 2009. Smoker was defined as a person who, at the time of survey smoked cigarettes either daily or occasionally. RESULTS Response rate was 65.4%, of these 396 (60.55%) were male and 88 (13.45%) were smokers. Smoking was more among the male students than females (p-value < 0.001). The greatest percentage of smokers was in 3rd Year (n = 29, 26.85%), majority were of 21-30 years age (n = 59, 19.53%), started smoking between 11-20 years (n = 48, 54.54%), smoked < 10 cigarettes/day (n = 37, 42.04%) and started smoking due to influence of friends (n = 53, 60.23%). Majority (n = 69, 78.4%) had no intention to quit in the next 6 months. Lack of Incentive (n = 32, 36.36%) and Addiction (n = 24, 27.27%) were the main reasons for not quitting. CONCLUSION Our results showed a substantial trend of cigarette smoking in medical students in Pakistan. Prevalence is more in higher classes. Majority have a smoker in their family and had started smoking under influence of peers and media. They find it relaxing and addictive, hence difficult to quit. Nicotine use was found to be uncommon.
Brain proteasomal function in sporadic Parkinson's disease and related disorders

Because genetic defects relating to the ubiquitin–proteasome system were reported in familial parkinsonism, we evaluated proteasomal function in autopsied brains with sporadic Parkinson's disease. We found that proteasome peptidase activities in a fraction specific to the proteasome were preserved in five brain areas (including the striatum) of Parkinson's disease where neuronal loss is not observed. Striatal protein levels of two proteasome subunits were normal in Parkinson's disease but reduced mildly in disease controls (multiple system atrophy). Our brain data suggest that a systemic, global disturbance in the catalytic activity and degradation ability of the proteasome itself is unlikely to explain the cause of Parkinson's disease.
Intrinsic Variability in Group and Individual Decision Making

The paper examines the random preference model, which can explain inherent variability of preferences in managerial and individual decision making and provides axiomatizations for the utility components of two such models differentiated by the structure of core preferences: expected utility (EU) and betweenness-like preferences. We then examine the possibility of violations of weak stochastic transitivity for these models and for a model with core dual EU preferences. Such violations correspond to the existence of Condorcet cycles, and therefore, the analysis has implications for managerial decision making and for majority rule voting. The paper also investigates implications of its findings for two popular experimental settings. This paper was accepted by James Smith, decision analysis.