Miracle-dz/UniFAR-FTUs huggingface dataset:
Risk factors for injury during basic military training. Is there a social element to injury pathogenesis?

A retrospective case-control study into the risk factors for injury during basic military training was conducted at the Recruit Training Unit, Royal Australian Air Force Base Edinburgh, South Australia. Case subjects were recruits suffering a musculoskeletal injury during the course, severe enough to result in backcoursing (being delayed and joining a later course) and usually requiring the loss of 5 days of training. Control subjects were 629 recruits selected randomly from recruits who were not case subjects from the same period of Jan 1, 1985 to Dec 31, 1990. Two hundred thirty-eight cases were identified (2.7% of the recruit population), of which 123 were overuse-type injuries and 115 acute-type injuries. Most injuries occurred in the first 2 weeks of training. Bivariate and logistic regression analysis of possible risk factors for injury was conducted, both for all case subjects and for the subgroup of case subjects with overuse injuries. Statistically significant associations were identified for female gender, body mass index > 26.9, winter training, a history of lower limb injury, and the presence of a lower limb deformity. All these associations were stronger for overuse injury, and preenlistment physical activity was also significantly associated with overuse injury. No significant association was found for height, weight, age, smoking, or gender makeup of courses. Most striking was a large rise in overuse injury incidence in women over the period of study, from 0.2% in 1985 to 8.8% in 1990. Reasons for this increase may include "social pathogenesis. "
Dedicated Double Breast Coil for Magnetic Resonance Mammography Imaging, Biopsy, and Preoperative Localization

Pfleiderer SOR, Reichenbach JR, Azhari T, et al. Dedicated double breast coil for magnetic resonance mammography imaging, biopsy, and preoperative localization. Invest Radiol 2003;38:1–8. Rationale and Objectives.The aim of this study was to compare the performance of a dedicated double breast coil for MR imaging and intervention with a standard diagnostic double breast coil. Materials and Methods.Signal-to-noise ratios (SNRs) were determined for both coils by using a water phantom. Fourteen patients were examined, 11 underwent preoperative hookwire localization, two were biopsied, and one received diagnostic imaging. Breast images were acquired in three patients with both coils and were visually compared. Harvested specimen from the biopsies and surgeries following hookwire localization were histopathologically evaluated. Results.SNR was superior with the interventional coil in the posterior (axillary) part of the imaging volume and inferior in the anterior part compared with the standard coil. Anatomic MR breast images were of similar diagnostic quality. For the two biopsy procedures the trocar was correctly placed in front of the suspicious lesion. Hookwires were correctly located inside the lesion in nine patients and in contact with the lesion in one patient. In one patient a 2 mm distance between the lesion and the wire was observed. Conclusions.Diagnostic imaging followed by subsequent MR-guided intervention is possible within a single session by using the dedicated interventional coil. The correct final position of the hookwires demonstrates the precision of the MR guided localization procedure.
Geographic Variation in the Taphonomic Effect of Vulture Scavenging: The Case for Southern Illinois

The taphonomic effect of vulture scavenging has been previously documented in central Texas (J Forensic Sci, 2009, 54, 524). This study reports on the behavioral differences between two species of vultures (Coragyps atratus, Cathartes aura) observed over a period of 1 year at the Complex for Forensic Anthropology Research in Southern Illinois. The decomposition of six research subjects and two control subjects was observed. Compared with the previous findings of vulture activity, the authors observed a severe delay in the time of first arrival (up to 28 days), decreased feeding time on remains (14–40 min), a less voracious feeding rate (7 days to 2 months to skeletonization), and a completely different feeding pattern of vultures in Southern Illinois. Additionally, no characteristic markings were observed on skeletal elements of research subjects. This study suggests the taphonomic effects of scavengers varies with climate and regions and may affect decomposition rates and patterns.
Impact of Comorbidity Type on Measures of Quality for Diabetes Care

ObjectiveStudies provide conflicting results about the impact of comorbid conditions on the quality of chronic illness care. We assessed the effect of comorbidity type (concordant, discordant, or both) on the receipt of guideline-recommended care among patients with diabetes. Research DesignPatients were assigned to 1 of 4 condition groups: diabetes-concordant (hypertension, ischemic heart disease, hyperlipidemia), and/or diabetes-discordant (arthritis, depression, chronic obstructive pulmonary disease) conditions, or neither. We evaluated hemoglobin A1c, blood pressure, and low-density lipoprotein cholesterol readings at index and measured overall good quality of diabetes care, including a 6-month follow-up interval. We assessed the effect of condition group on overall good quality of care with logistic regression and generalized ordered logistic regression. ResultsWe assigned 35,872 patients to the diabetes comorbid condition groups, ranging from 2.0% in the discordant-only group to 58.0% in the concordant-only group. Patients with both types of conditions were more likely than those with no comorbidities to receive overall good quality for glycemic [odds ratio (OR), 2.13; 95% confidence interval (CI), 1.86-2.41], blood pressure (OR, 1.62; 95% CI, 1.40-1.84), and low-density lipoprotein cholesterol (OR, 3.57; 95% CI, 3.08-4.05) control within 6 months of an index visit. They were also more likely to receive overall good quality for all 3 quality measures combined (OR, 2.17; 95% CI, 1.96-2.39). ConclusionsPatients with the greatest clinical complexity were more likely than less complex patients to receive high quality diabetes care, suggesting that increased complexity does not necessarily predispose chronically ill patients to receiving poorer care. However, caution should be used in treating certain patient groups, such as the elderly, for whom adherence to multiple condition-specific guidelines may lack benefit or cause harm.
A New Mutation in FIG4 Causes a Severe Form of CMT4J Involving TRPV4 in the Pathogenic Cascade

Mutations in FIG4, coding for a phosphoinositol(3,5) bisphosphate 5' phosphatase and involved in vesicular trafficking and fusion, have been shown causing a recessive form of Charcot-Marie-Tooth (CMT). We have identified a novel intronic mutation in the FIG4 in a wheel-chair bound patient presenting with a severe form of CMT4J and provide a longitudinal study. Investigations indicated a demyelinating sensorimotor polyneuropathy with diffuse active denervation and severe axonal loss. Genetic testing revealed that the patient is heterozygous for 2 FIG4 mutations, p.I41T and a T > G transversion at IVS17-10, the latter predicted to cause a splicing defect. FIG4 was severely diminished in patient's fibroblasts indicating loss-of-function. Consistent with FIG4's function in phosphoinositol homeostasis and vesicular trafficking, fibroblasts contained multiple large vacuoles and vesicular organelles were abnormally dispersed. FIG4 deficiency has implications for turnover of membrane proteins. The transient receptor cation channel, TRPV4, accumulated at the plasma membrane of patient's fibroblasts due to slow turnover. Knocking down Fig4 in murine cultured motor neurons resulted in vacuolation and cell death. Inhibiting TRPV4 activity significantly preserved viability, although not correcting vesicular trafficking. In conclusion, we demonstrate a new FIG4 intronic mutation and, importantly, a functional interaction between FIG4 and TRPV4.
Identification of Plagl1/Zac1 binding sites and target genes establishes its role in the regulation of extracellular matrix genes and the imprinted gene network

Abstract PLAGL1/ZAC1 undergoes parental genomic imprinting, is paternally expressed, and is a member of the imprinted gene network (IGN). It encodes a zinc finger transcription factor with anti-proliferative activity and is a candidate tumor suppressor gene on 6q24 whose expression is frequently lost in various neoplasms. Conversely, gain of PLAGL1 function is responsible for transient neonatal diabetes mellitus, a rare genetic disease that results from defective pancreas development. In the present work, we showed that Plagl1 up-regulation was not associated with DNA damage-induced cell cycle arrest. It was rather associated with physiological cell cycle exit that occurred with contact inhibition, growth factor withdrawal, or cell differentiation. To gain insights into Plagl1 mechanism of action, we identified Plagl1 target genes by combining chromatin immunoprecipitation and genome-wide transcriptomics in transfected cell lines. Plagl1-elicited gene regulation correlated with multiple binding to the proximal promoter region through a GC-rich motif. Plagl1 target genes included numerous genes involved in signaling, cell adhesion, and extracellular matrix composition, including collagens. Plagl1 targets also included 22% of the 409 genes that make up the IGN. Altogether, this work identified Plagl1 as a transcription factor that coordinated the regulation of a subset of IGN genes and controlled extracellular matrix composition.
Moral Hazard in Natural Disaster Insurance Markets: Empirical Evidence from Germany and the United States

Moral hazard in natural disaster insurance markets results in policyholders preparing less, increasing the risk they face. However, moral hazard may not arise, due to high risk aversion or market context. We study the relationship between disaster risk reduction and insurance coverage to assess the presence of moral hazard for two different natural hazards, using four econometric models on survey data from Germany and the United States. The results show that moral hazard is absent. Nevertheless, adverse risk selection may be present. This has significant policy relevance such as opportunities for strengthening the link between insurance and risk reduction measures. (JEL Q54)
Sensory-motor deficits in children with fetal alcohol spectrum disorder assessed using a robotic virtual reality platform.

BACKGROUND Fetal alcohol spectrum disorder (FASD) is associated with a large number of cognitive and sensory-motor deficits. In particular, the accurate assessment of sensory-motor deficits in children with FASD is not always simple and relies on clinical assessment tools that may be coarse and subjective. Here we present a new approach: using robotic technology to accurately and objectively assess motor deficits of children with FASD in a center-out reaching task. METHODS A total of 152 typically developing children and 31 children with FASD, all aged between 5 and 18 were assessed using a robotic exoskeleton device coupled with a virtual reality projection system. Children made reaching movements to 8 peripheral targets in a random order. Reach trajectories were subsequently analyzed to extract 12 parameters that had been previously determined to be good descriptors of a reaching movement, and these parameters were compared for each child with FASD to a normative model derived from the performance of the typically developing population. RESULTS Compared with typically developing children, the children with FASD were found to be significantly impaired on most of the parameters measured, with the greatest deficits found in initial movement direction error. Also, children with FASD tended to fail more parameters than typically developing children: 95% of typically developing children failed fewer than 3 parameters compared with 69% of children with FASD. These results were particularly pronounced for younger children. CONCLUSIONS The current study has shown that robotic technology is a sensitive and powerful tool that provides increased specificity regarding the type of motor problems exhibited by children with FASD. The high frequency of motor deficits in children with FASD suggests that interventions aimed at stimulating and/or improving motor development should routinely be considered for this population.
Pregnancy‐associated plasma protein‐A (PAPP‐A): concentration in uterine fluid and immunohistochemical localization in the endometrium

Summary. Pregnancy‐associated plasma protein‐A (PAPP‐A) was localized immunohistochemically in the endometrium and measured in uterine fluid of non‐pregnant women. The variations of PAPP‐A concentrations in uterine fluid during the menstrual cycle paralleled those found in the endometrium. In patients receiving hormone therapy there was a significant correlation between the uterine fluid PAPP‐A concentration and the progestogen to oestrogen potency ratio of the hormonal treatment. The presence of PAPP‐A in the uterine fluid cannot simply be explained by blood contamination or cell damage. These results are interpreted as indirect evidence for an exocrine as well as an endocrine secretion of PAPP‐A by the endometrium which might be influenced by hormones.
Waiting times before dental care under general anesthesia in children with special needs in the Children's Hospital of Casablanca

Introduction Oral diseases may have an impact on quality of children's life. The presence of severe disability requires the use of care under general anesthesia (GA). However, because of the limited number of qualified health personnel, waiting time before intervention can be long. Aim: To evaluate the waiting time before dental care under general anesthesia for children with special needs in Morocco. Methods A retrospective cohort study was carried out in pediatric dentistry unit of the University Hospital of Casablanca. Data were collected from records of patients seen for the first time between 2006 and 2011. The waiting time was defined as the time between the date of the first consultation and intervention date. Results 127 children received dental care under general anesthesia, 57.5% were male and the average age was 9.2 (SD = 3.4). Decay was the most frequent reason for consultation (48%), followed by pain (32%). The average waiting time was 7.6 months (SD = 4.2 months). The average number of acts performed per patient was 13.5. Conclusion Waiting times were long, it is necessary to take measures to reduce delays and improve access to oral health care for this special population.
Home accidents in the elderly in Turkey.

Houses may accommodate environmental barriers that pose a risk for older people. This study aimed to identify the main characteristics of the dwellings of the elderly, and to assess the impact of those on home accidents. In that cross-sectional study, 3,277 people over 60 years of age living in Aydin province of Turkey were evaluated in December 2004, using a questionnaire and a home safety check list. The results indicated that 38.6% of the elderly have had any type of home accident within the last 12 months, and the most common type of accident was falls (31.9% of all accidents). Possible causes of accidents were analyzed and the houses were graded based on two different types of safety point scales (SP): SP1 for "house characteristics" and SP2 for "personal opinions. " According to SP1, 22.7% of the houses were defined as in poor condition while this percentage was 20.1% according to SP2. Poor housing conditions, being female, living alone, having a chronic illness, physical and hearing disability, wearing eyeglasses, inactivity, use of assistive devices and more than four drugs were found to be associated with having a home accident. The environmental hazards and factors contributing to accidents or injuries were well-known. However, the information about home accidents in the elderly and the impact of dwelling characteristics was limited. This study was considered to be helpful to provide a new perspective on this subject. More studies are needed using the home safety check lists to collect additional quantitative data.
Ciliary dyskinesia with normal ultrastructure.

There is increasing awareness of the association between primary ciliary abnormalities and bronchiectasis. The most frequently recognised is that between dynein deficient cilia and Kartageneres syndrome. ' Afzelius, however, predicted that without embryonic ciliary movement the rotation of the archenteron would be random and that in half of the cases of the "immotile cilia syndrome" there would be a normal cardiac situs.2 In recent years other primary structural abnormalities of cilia have been described in association with lower respiratory tract infection-namely absence of radial spokes3 and transposition of the microtubules.4 The finding that some individuals with Kartagener's syndrome have normal ciliary ultrastructureS6 implies that either the association of the clinical syndrome with abnormal cilia does not always hold or that functional abnormalities of cilia may occur in the absence of ultrastructural defects. No observations of ciliary motility have been reported on patients with Kartageneres syndrome and normal ciliary ultrastructure. With Kartagener's syndrome the presence of ciliary dysfunction is readily suspected, but in patients with ciliary dyskinesia and normal situs (who also present with symptoms of sinusitis and bronchiectasis or recurrent chest infections) a functional abnormality may not be recognised unless tests of ciliary motility are performed. We report two cases of ciliary dyskinesia and associated clinical abnormalities but normal ciliary ultrastructure.
On-the-fly domain adaptation of binary classifiers

This work considers the on-the-fly domain adaptation of supervised binary classifiers, learned off-line, in order to adapt them to a target context. The probability density functions associated to negative and positive classes are supposed to be mixtures of the source distributions. Moreover, the mixture weights and the priors are only available at runtime. We present a theoretical solution to this problem, and demonstrate the effectiveness of the proposed approach on a real computer vision application. Our theoretical solution is applicable to any classifier approximating Bayes’ classifier.
Investigation of the effect of combined variations in temperature, pH, and NaCl concentration on nisin inhibition of Listeria monocytogenes and Staphylococcus aureus

Gradient plates were used to investigate the effects of varying temperature, pH, and sodium chloride (NaCl) concentration on nisin inhibition of Staphylococcus aureus and Listeria monocytogenes, Nisin was incorporated into the plates of 0, 50, 100, 250, and 500 IU ml -1. Gradients of pH (3.7 to 7.92) at right angles to NaCl concentration (2.1 to 7% [wt/vol]) were used for the plates, which were incubated at 20, 25, 30 and 35 degrees C. Growth on the plates were recorded by eye and by image analysis. The presence of viable but nongrowing cells was revealed by transfer to nongradient plates. Lower temperatures and greater NaCl concentrations increased the nisin inhibition of S. aureus synergistically. Increasing the NaCl concentration potentiated the nisin action against L. monocytogenes; the effect of temperature difference was not so apparent. Between pH 7.92 and ca. pH 5, a fall pH appeared to increase nisin's effectiveness against both organisms. At more acid pH values (ca. pH 4.5 to 5), the organisms showed resistance to both nisin and NaCl at 20 and 25 degrees C. Similar results were obtained with one-dimensional liquid cultures.
C-Reactive Protein in the Arterial Intima: Role of C-Reactive Protein Receptor–Dependent Monocyte Recruitment in Atherogenesis

Infiltration of monocytes into the arterial wall is an early cellular event in atherogenesis. Recent evidence shows that C-reactive protein (CRP) is deposited in the arterial intima at sites of atherogenesis. In this study, we demonstrate that CRP deposition precedes the appearance of monocytes in early atherosclerotic lesions. CRP is chemotactic for freshly isolated human blood monocytes. A specific CRP receptor is demonstrated on monocytes in vitro as well as in vivo, and blockage of the receptor by use of a monoclonal anti-receptor antibody completely abolishes CRP-induced chemotaxis. CRP may play a major role in the recruitment of monocytes during atherogenesis.
Regulation of UmuD cleavage: role of the amino-terminal tail.

An essential step in SOS mutagenesis is the RecA-mediated posttranslational processing of UmuD-like proteins to the shorter, but mutagenically active, UmuD'-like proteins. Interestingly, the UmuD-like proteins undergo posttranslational processing at different rates. For example, although the Escherichia coli UmuD (UmuDEc) and the Salmonella typhimurium UmuD (UmuDSt) proteins are 73% identical, UmuDSt is processed in vivo at a significantly faster rate than the UmuDEc protein. Here, we report experiments aimed at investigating the molecular basis of these phenotypic differences. The faster rate of UmuDSt cleavage probably does not result solely from a better interaction with RecA, since we observed that, in vitro, UmuDSt undergoes RecA-independent autocatalytic processing about four-times faster than UmuDEc. By constructing chimeric UmuD proteins, we determined that the amino-terminal tail of the UmuD proteins proximal to the Cys24-Gly25 cleavage site is mainly responsible for the difference in UmuDSt and UmuDEc cleavage rates. Site-directed mutagenesis of the UmuDEc protein suggests that most of the enhanced cleavage observed with the UmuDSt protein can be attributed to the presence of a Pro23 residue, juxtaposed to the cleavage site in UmuDSt. Furthermore, this proline residue appears to result in a UmuD protein that is a much better substrate for intermolecular cleavage. These findings clearly implicate the N-terminal tail of the UmuD-like proteins as playing an important and unexpected regulatory function in the maturation of the mutagenically active UmuD'-like mutagenesis proteins.
SERUM ANTIOTENSIN CONVERTING ENZYME ACTIVITY IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

It is well recognized that diabetes mellitus is associated with an increase in kidney size, in both humans and experimental animals (1,2). The morphologic changes that occur in diabetic organs have been best characterized in the kidney. Early in the course of diabetes, kidney cells undergo hypertrophy and, later on, hyperplasia (3). Recent evidence indicates a possible role for the renin-angiotensin system (RAS) in the pathogenesis of glomerular injury in diabetes mellitus (4). RAS has important hemodynamic and growth-enhancing properties, which may play role in the development of diabetic microvascular complications (5). However, in the diabetic human and rat, the results of studies on the activity of the serum angiotensin converting enzyme (ACE), the major enzyme regulating angiotensin II production, have been conflicting. ACE activity, in both humans and rats has been reported as being decreased (6, 7), normal (8, 4) or even elevated (9, 10, 11). Therefore, the present study was designed to clarify the direct effect of diabetes on serum ACE activity in streptozotocin (STZ) -induced rats.