Miracle-dz/UniFAR-FTUs huggingface dataset:
Structure and function of the homeotic gene complex (HOM‐C) in the beetle, Tribolium castaneum

The powerful combination of genetic, developmental and molecular approaches possible with the fruit fly, Drosophila melanogaster, has led to a profound understanding of the genetic control of early developmental events. However, Drosophila is a highly specialized long germ insect, and the mechanisms controlling its early development may not be typical of insects or Arthropods in general. The beetle, Tribolium castaneum, offers a similar opportunity to integrate high resolution genetic analysis with the developmental/molecular approaches currently used in other organisms. Early results document significant differences between insect orders in the functions of genes responsible for establishing developmental commitments.
GROWTH REQUIREMENTS OF BACTERIAL VIRUSES.

The problem of the growth requirements of bacteria is generally considered to consist of a description of those organic and inorganic components in the medium which must penetrate the organism to become available for various metabolic or structural roles essential to the production of a like organism2. It also includes a definition of these roles, metabolic, structural, or both. Implicit in an approach to the problem is the knowledge that the bacteria contain the enzymes capable of synthesizing and assembling their own macromolecular components. Since the growth of bacterial viruses has to date been shown to occur only in an ordered enzymatic environment, as in living cells3, the problem under discussion must be expanded to include the question, "How much of the enzymatic functions of virus synthesis are accomplished by the host cell? " or, conversely, "To what extent does the virus contribute to its own synthesis? " Therefore, it is clear that the problem of the growth requirements of viruses is a far more complex problem than for bacteria. The environment essential for multiplication of any virus consists of the numerous organized macromolecular components of a living cell. These components, in turn, may be affected by variations in the external environment of the cell. Since it is difficult to vary the interior of the cell directly and controllably, the external environment of the infected host has been varied most frequently
THE EFFECT OF SACCHAROMYCES CEREVISIAE ON RUMINAL FERMENTATION IN DAIRY COWS

This study presents the results of an experiment in which the effect of addition of a yeast culture (Saccharomyces cerevisiae, Strain 47) on rumen fermentation was studied in thirty-six dairy cows of Holstein breed. The animals were divided into one control and five experimental groups. Each group involved 6 individuals. The animals received a diet consisting of good maize silage with a higher dry matter content (16 kg), clover-grass haylage (l6 kg), meadow hay (3 kg) and supplementary feed mixture (7.5 kg). The rations were fed to cows as total mixed ration (TMR). In experimental groups, the yeast culture was added into the feed mixture in amounts of 2, 4, 6, 8, 10 g per day and animal. Samples of rumen fluid were taken perorally 3–4 hours after feeding. The obtained results indicated that the addition of a Saccharomyces cerevisiae SC-47 culture in recommended doses showed a positive effect on ruminal digestion. As compared with control, the addition of all aforementioned amounts of the yeast culture into the feeding ration resulted in all cases in a statistically significant (P < 0.01) decrease in pH and fluctuated near the lower limit of the reference values. As compared with control, the yeast culture supplementation showed a positive effect (P < 0.01) on production of volatile fatty acids (VFA) (127.6 vs. 84.0 mmol/l). The utilisation of ammonia was higher (P < 0.01) in experimental groups (8.12, resp. 8.68 mmol/l) than in controls (9.06 mmol/l). The difference in protozoa numbers in rumens of dairy cows in the control and experimental groups was statistically highly significantly (P < 0.01) different. There was a close relationship between the dose of yeast culture on the one hand and the VFA content and protozoa numbers on the other. The regression analysis of dependence of dependent variable (i.e. pH of rumen fluid) on the independent one (i.e. the dose of yeast culture) revealed only a slight degree of dependence (r = 0.671).
Research Report: The Evolving Relationship Between General and Specific Computer Self-Efficacy - An Empirical Assessment

The concept of computer self-efficacy (CSE) recently has been proposed as important to the study of individual behavior toward information technology. This paper extends current understanding about the concept of self-efficacy in the context of computer software. We describe how two broad types of computer self-efficacy beliefs, general self-efficacy and task-specific self-efficacy, are constructed across different computing tasks by suggesting that initial general CSE beliefs will strongly predict subsequentspecific CSE beliefs. The theorized causal relationships illustrate the malleability and development of CSE beliefs over time, within a training environment where individuals are progressively provided with greater opportunity for hands-on experience and practice with different software. Consistent with the findings of prior research, judgments of self-efficacy then serve as key antecedents of the perceived cognitive effort (ease of use) associated with technology usage. Further, we theorize that self-efficacy judgments in the task domain of computing are strongly influenced by the extent to which individuals believe that they are personally innovative with respect to information technology. Panel data were collected using a longitudinal research design within a training context where 186 subjects were taught two software packages in a sequential manner over a 14-week period. The emergent patterns of the hypothesized relationships are examined using structural equation modeling techniques. Results largely support the relationships posited.
Prevalence of HIV infection in provincial prisons in British Columbia.

OBJECTIVE To ascertain the prevalence of HIV infection among people entering provincial adult prisons in British Columbia and to study associations between HIV infection and specific demographic and behavioural characteristics. DESIGN Prospective, unlinked, voluntary survey involving HIV antibody testing of saliva specimens. SETTING All adult provincial prisons in British Columbia through which inmates are admitted to the provincial correctional system. PARTICIPANTS All adult inmates admitted to provincial prisons in British Columbia between Oct. 1 and Dec. 31, 1992. OUTCOME MEASURES Rate of HIV positivity. Independent variables included sex, native status (native or non-native), self-reported HIV status, age group and history of injection drug use. RESULTS A total of 2482 (91.3%) of 2719 eligible inmates volunteered for testing. Refusal was not associated with sex, native status, self-reported HIV status or age group; inmates who reported a history of injection drug use were more likely than the others to refuse HIV antibody testing (12.9% v. 6.8%; p < 0.001). The 2482 inmates who were tested for HIV were similar to the general inmate population with regard to sex, native status and age group. A total of 28 inmates were confirmed to be HIV positive, for an overall prevalence rate in the study population of 1.1% (95% confidence interval 0.8% to 1.6%). The prevalence rates were higher among the women than among the men (3.3% v. 1.0%; p = 0.023, Fisher's exact test) and among the inmates who reported a history of injection drug use than among those who did not report such a history (2.4% v. 0.6%; p < 0.001). There was no association between HIV status and native status or age group. Logistic regression analysis revealed the higher prevalence rate among the women to be explained by more of the women than of the men reporting a history of injection drug use. Of the 30 people who stated that they were HIV positive and who were tested, 19 (63.3%) had a negative result; conversely, 17 who reported that they were HIV negative or had not been tested had a positive result. CONCLUSIONS Unlinked, voluntary HIV antibody testing of inmates can achieve high participation rates. The overall prevalence rate of 1.1% and the rate among the female inmates of 3.3% confirm that HIV infection is a reality in prisons and that the virus has established a clear foothold in inmate populations. Harm-reduction interventions should include a comprehensive education program for inmates on infectious diseases, the availability of condoms throughout prisons and the distribution of bleach for sterilizing needles and syringes. From a public health perspective, these data suggest an urgent need for access to sterile injection equipment in addition to other preventive measures.
每月一書：Lean In: Women, Work, and the Will to Lead

Thirty years after women became 50 percent of the college graduates in the United States, men still hold the vast majority of leadership positions in government and industry. This means that women’s voices are still not heard equally in the decisions that most affect our lives. In LEAN IN, Sheryl Sandberg examines why women’s progress in achieving leadership roles has stalled, explains the root causes, and offers compelling, commonsense solutions that can empower women to achieve their full potential.
Dialysate Potassium, Serum Potassium, Mortality, and Arrhythmia Events in Hemodialysis: Results From the Dialysis Outcomes and Practice Patterns Study (DOPPS).

BACKGROUND Sudden death is a leading cause of death in patients on maintenance hemodialysis therapy. During hemodialysis sessions, the gradient between serum and dialysate levels results in rapid electrolyte shifts, which may contribute to arrhythmias and sudden death. Controversies exist about the optimal electrolyte concentration in the dialysate; specifically, it is unclear whether patient outcomes differ among those treated with a dialysate potassium concentration of 3 mEq/L compared to 2 mEq/L. STUDY DESIGN Prospective cohort study. SETTING & PARTICIPANTS 55,183 patients from 20 countries in the Dialysis Outcomes and Practice Patterns Study (DOPPS) phases 1 to 5 (1996-2015). PREDICTOR Dialysate potassium concentration at study entry. OUTCOMES Cox regression was used to estimate the association between dialysate potassium concentration and both all-cause mortality and an arrhythmia composite outcome (arrhythmia-related hospitalization or sudden death), adjusting for potential confounders. RESULTS During a median follow-up of 16.5 months, 24% of patients died and 7% had an arrhythmia composite outcome. No meaningful difference in clinical outcomes was observed for patients treated with a dialysate potassium concentration of 3 versus 2 mEq/L (adjusted HRs were 0.96 [95% CI, 0.91-1.01] for mortality and 0.98 [95% CI, 0.88-1.08] for arrhythmia composite). Results were similar across predialysis serum potassium levels. As in prior studies, higher serum potassium level was associated with adverse outcomes. However, dialysate potassium concentration had only minimal impact on serum potassium level measured predialysis (+0.09 [95% CI, 0.05-0.14] mEq/L serum potassium per 1 mEq/L greater dialysate potassium concentration). LIMITATIONS Data were not available for delivered (vs prescribed) dialysate potassium concentration and postdialysis serum potassium level; possible unmeasured confounding. CONCLUSIONS In combination, these results suggest that approaches other than altering dialysate potassium concentration (eg, education on dietary potassium sources and prescription of potassium-binding medications) may merit further attention to reduce risks associated with high serum potassium levels.
Molecular Evidence of Coinfection of Borrelia burgdorferi Sensu Lato, Human Granulocytic Ehrlichiosis Agent, and Babesia microti in Ticks From Northwestern Poland

To assess the potential risk for tick-borne agents, Ixodes ricinus were collected from 2 sites in northwestern Poland. The ticks were tested by polymerase chain reaction for coinfection with Borrelia burgdorferi sensu lato (s. l.), human granulocytic ehrlichiosis (HGE) agent, and Babesia microti. Of the 533 processed ticks, 16.7% were positive for B. burgdorferi s. l. , 13.3% for B. microti, and 4.5% for the HGE agent. Twenty ticks were coinfected with 2 or 3 of the pathogens.
Thermodynamics of anomalous diffusion.

It is pointed out that the generalized statistical mechanics introduced by Tsallis [J. Stat. Phys. 52, 479 (1988)] provides a natural frame for developing a thermodynamical formalism of anomalous diffusion. Within such a frame, we calculate the mean square displacement as a function of time and generalize the Einstein relation of diffusivity and temperature for random walks of the Levy-Right type.
Anatomic Considerations for Safe Placement of Calcaneal Pins

Placement of a Steinmann pin in the calcaneus is indicated in various orthopaedic conditions. Planning the point of entry and the direction of transcalcaneal pin insertion is crucial for avoidance of neurovascular injury, tendon injury, and subtalar joint violation. Fifteen cadaveric feet were studied in which transfixing calcaneal pins were inserted in posteromedial and anteromedial sites. The posteromedial site was at a point ¾ the distance between the palpable tip of the medial malleolus and the heel, with the pin inserted transversely. The anteromedial site was at the sustentaculum tali with the pin inserted transversely angled 25 ° to 30 ° inferolaterally. Radiographs were then taken and the specimens were dissected to determine the path of each pin and the safe and danger zones for transcalcaneal pin placement. It was concluded that the posteromedial calcaneal pin site is safer and easier to determine.
Endogenous antioxidant defence system in rat liver following mercury chloride oral intoxication

Mercury is a highly toxic metal which induces oxidative stress. Superoxide dismutases, catalase, and glutathion peroxidase are proteins involved in the endogenous antioxidant defence system. In the present study rats were administered orally, by gavage, a single daily dose of HgCl2 for three consecutive days. In order to find a relation between the proteins involved in the antioxidant defence and mercury intoxication, parameters of liver injury, redox state of the cells, as well as intracellular protein levels and enzyme activities of Mn‐dependent superoxide dismutase (MnSOD), Cu‐Zn‐dependent superoxide dismutase (CuZnSOD), catalase, and glutathione peroxidase (GPx) were assayed both in blood and in liver homogenates.
Lack of selective Vβ deletion in peripheral CD4+ T cells of human immunodeficiency virus‐infected infants

To investigate the possibility of superantigen‐mediated deletions of T cells expressing particular T cell receptor Vβ (TcR Vβ) gene segments during human immunodeficiency virus (HIV) infection, TcR Vp usage in CD4+ and CD8+ subsets was analyzed in a cohort of infants maternally infected by HIV and in a group of healthy neonates. We used a semi‐quantitative anchored polymerase chain reaction technique together with cytofluorographic analysis with anti‐Vβ monoclonal antibodies. The representation of the 24 vβ families in CD4+ and CD8+ T cells from normal neonates was very similar to that in adults. Preferential expression of Vβ2 in the CD4+ subset was observed in both the neonates and in healthy adults. The representation of the 24 Vβ families in peripheral CD4+ T cells from the HIV‐infected infants showed no selective vβ deletion, even when the CD4+ subset was globally depleted. Moreover, the main characteristics of the control group (predominance of certain Vβ families and Vβ2 skewing towards the CD4+ subset) were also present in all the HIV‐infected infants.
The small GTPase Rap1 is a novel regulator of RPE cell barrier function.

PURPOSE To determine whether the small GTPase Rap1 regulates the formation and maintenance of the retinal pigment epithelial (RPE) cell junctional barrier. METHODS An in vitro model was used to study RPE barrier properties. To dissect the role of Rap1, two techniques were used to inhibit Rap1 function: overexpression of RapGAP, which acts as a negative regulator of endogenous Rap1 activity, and treatment with engineered, adenovirally-transduced microRNAs to knockdown Rap1 protein expression. Transepithelial electrical resistance (TER) and real-time cellular analysis (RTCA) of impedance were used as readouts for barrier properties. Immunofluorescence microscopy was used to visualize localization of cadherins under steady state conditions and also during junctional reassembly after calcium switch. Finally, choroidal endothelial cell (CEC) migration across RPE monolayers was quantified under conditions of Rap1 inhibition in RPE. RESULTS Knockdown of Rap1 or inhibition of its activity in RPE reduces TER and electrical impedance of the RPE monolayers. The loss of barrier function is also reflected by the mislocalization of cadherins and formation of gaps within the monolayer. TER measurement and immunofluorescent staining of cadherins after a calcium switch indicate that junctional reassembly kinetics are also impaired. Furthermore, CEC transmigration is significantly higher in Rap1-knockdown RPE monolayers compared with control. CONCLUSIONS Rap1 GTPase is an important regulator of RPE cell junctions, and is required for maintenance of barrier function. This observation that RPE monolayers lacking Rap1 allow greater transmigration of CECs suggests a possible role for potentiating choroidal neovascularization during the pathology of neovascular age-related macular degeneration.
Intratumoral microvessel density, response to chemotherapy and clinical outcome of patients with advanced ovarian carcinoma.

BACKGROUND The aim of this study was to assess intratumoral microvessel density (IMD) in tissue samples from primary ovarian carcinomas, and to correlate this angiogenic parameter with the common clinico-pathological variables, response to chemotherapy and prognosis of patients with this malignancy. PATIENTS AND METHODS The investigation was conducted on 64 patients who underwent initial surgery for FIGO stages I-IV ovarian carcinoma. Paraffin-embedded sections of primary tumor specimens were analyzed for IMD by immunohistochemistry using anti-CD34 antibodies. In detail, we assessed the 49 patients with advanced (FIGO stages II-IV) disease. Postoperative chemotherapy consisted of paclitaxel/platinum-based chemotherapy in 36 (73.5%) patients and platinum-based chemotherapy in 13. RESULTS The IMD ranged from 6 to 115 microvessels/field, with a median value of 40, and correlated with none of the common clinico-pathological variables of ovarian carcinoma. As for the patients with advanced disease, women with elevated IMD (> or = 40 microvessels/field) had a higher chance of achieving a complete response to chemotherapy when compared to those with lower IMD (p = 0.0068). Multiple logistic regression showed that IMD was an independent predictor of complete response to chemotherapy (p = 0.0094). By log-rank test, patients with elevated IMD had a better progression-free survival (p = 0.0039) and a better overall survival (p = 0.0365) when compared to those with lower IMD. The Cox model showed that IMD was the only independent prognostic variable for both progression-free survival (p = 0.0112) and overall survival (p = 0.0296). DISCUSSION The present retrospective analysis seems to show a positive association between IMD, response to chemotherapy, mainly represented by a paclitaxel/platinum-based regimen, and clinical outcome of patients with advanced ovarian carcinoma.
Default Prediction Models a Comparison between Market Based Models and Accounting Based: Case of the Zimbabwe Stock Exchange 2010-2013

Default prediction is relevant to equity investors in Zimbabwe. The study examined the performance of two bankruptcy prediction models, the accounting ratio-based (Z-Score) model and the market based (KMV distance to default) model. The Z-Score model developed has two variables, market value to long term debt and EBIT to current liabilities and uniquely describe Zimbabweâ€™s corporate environment. The research concluded that accounting model (Z-Score) has superior bankruptcy prediction power. The model achieved 0.959 accuracy ratio against the market based model 0.509. Companies that went bankrupt during the period had shown signs of poor financial performance in prior years.
Italian children's understanding of the epistemic and deontic modal verbs dovere (must) and potere (may)

This study assesses children's understanding of the Italian modal verbs dovere (must) and potere (may) in their dual function of qualification of the speaker's beliefs (epistemic modality) and behaviour regulation (deontic modality). 192 children and 60 adults participated in the experiment. Children aged 3;0 to 9;2 were presented with two tasks: one assessed their understanding of modal expressions in the epistemic domain – looking for an object by following the information contained in a sentence; the other assessed their understanding of modal expressions in the deontic domain – acting according to obligations, permissions and prohibitions in the context of a game. Half of the subjects carried out the tasks in a single-sentence format and half carried out the tasks in a double-sentence format. In the single-sentence format the subjects had to follow the directions supplied by a modalized sentence; in the double-sentence format they had to follow the directions supplied by the sentence containing the stronger modal verb. Our results show that the understanding of deontic modal forms precedes the understanding of epistemic modal forms and that a full understanding of the strength of different modal forms is achieved only at eight years.
Causal Relationships among Dimensions of Consumer-Based Brand Equity and Purchase Intention: Fashion Industry

Due to the intense competition in market place, customers nowadays are exposed to several brands from across the globe. Building the brand equity becomes an important source of differentiation. It is widely recognized the important role of brand image in establishing brand awareness and brand attitude. Numbers of research are still debating on relationship among the dimensions of brand equity and yet no conclusive decision has been made. The purpose of the research is to investigate the relationship among the dimensions of brand equity and propose a model that predicts the purchase intention in fashion industry. The result confirms the casual relationship among the dimensions of brand equity. Interestingly perceived quality rather than brand image has stronger impact on brand loyalty and brand loyalty rather than perceived quality has stronger impact on purchase intention. This study contributes the original model of customer based brand equity of Aaker by introducing brand image as one of the assets to measure the brand equity concept. Strategic guidelines are provided to managers in building the brand loyalty.
Diagnosis, Prevention and Management of Thromboembolism

of such trials, for failure to prevent the formation of clinically insignificant calf thrombi does not necessarily mean that propagation and the incidence of pulmonary embolism is unaffected. For instance, elastic stockings fail to prevent small thromboses detected by 1251-fibrinogen (Rosengarten et al. 1970, Browse et al. 1974), but they do appear to be effective in reducing the incidence of major pulmonary embolism (Wilkins et al. 1952). 1251-fibrinogen is useless above the inguinal ligament or in the presence of healing wounds. It is contraindicated in young or pregnant patients. It is not very suitable for routine clinical work because, with its extreme sensitivity, it detects thrombi which are of little clinical significance. The method's main place is in research.