Miracle-dz/UniFAR-FTUs huggingface dataset:
Benefit of cardiac N13 PET CFR for combined anatomical and functional diagnosis of ischemic coronary artery disease : a pilot study

Background Cardiac positron emission tomography (PET) can lead to flow impairment quantification using PET coronary flow reserve (CFRp: ratio of stress flow to rest flow) and is superior to the current standard, singlephoton emission computed tomography. In this study, our first aim was to assess the benefit of CFRp in place of invasive CFR (CFRi) by comparing the correlations of each of the indices with combined pressure and flow index CDP, and combined functional (pressure-flow) and anatomical (%area stenosis, %AS) index, LFC. The second aim was to test the correlation between CFRp and CFRi. Methods N-13 ammonia PET scans were performed and CFRp was obtained using a 1-compartment 2K-dynamic volume (DV)-constant kinetic model in Flowquant. During catheterization, simultaneous pressure and flow readings were obtained in 10 vessels (three vessels in one patient, one vessel each in 7 patients) using a dual sensor tipped Combowire, and CFRi, CDP, LFC, and FFR were computed. %AS was obtained using quantitative coronary angiography. CDP was correlated with invasive pressure index (FFR) and CFRp and with FFR and CFRi. LFC was correlated with the %AS, FFR, and CFRp/CFRi, individually and in combination. Correlation analysis was done in SAS; p \ 0.05 was used for statistical significance. Results The correlations between CDP vs FFR and CFRp (r = 0.62, p = 0.19) in combination, as well as CDP vs FFR and CFRi in combination (r = 0.58, p = 0.24) remained similar. The correlation between LFC vs FFR, CFRp and %AS in combination improved (r = 0.82) with a near-significant p = 0.06, in comparison to the correlation between LFC vs FFR, CFRi and %AS in combination (r = 0.75, p = 0.15). CFRp correlated strongly and significantly (r = 0.82, p = 0.003) with CFRi, and the values were within 11 %. Conclusion The novelty of the PET procedure in this study is that the noninvasive CFRp can be used instead of invasive CFRi for the functional diagnosis of CAD. Therefore, a PET scan can reduce procedure time and cost while simplifying the diagnostic protocol for assessing coronary artery disease, thus benefitting both the patients and clinicians.
Improved linearity using harmonic error rejection in a full-field range imaging system

Full field range imaging cameras are used to simultaneously measure the distance for every pixel in a given scene using an intensity modulated illumination source and a gain modulated receiver array. The light is reflected from an object in the scene, and the modulation envelope experiences a phase shift proportional to the target distance. Ideally the waveforms are sinusoidal, allowing the phase, and hence object range, to be determined from four measurements using an arctangent function. In practice these waveforms are often not perfectly sinusoidal, and in some cases square waveforms are instead used to simplify the electronic drive requirements. The waveforms therefore commonly contain odd harmonics which contribute a nonlinear error to the phase determination, and therefore an error in the range measurement. We have developed a unique sampling method to cancel the effect of these harmonics, with the results showing an order of magnitude improvement in the measurement linearity without the need for calibration or lookup tables, while the acquisition time remains unchanged. The technique can be applied to existing range imaging systems without having to change or modify the complex illumination or sensor systems, instead only requiring a change to the signal generation and timing electronics.
Neck compartmentalization as the molecular basis for the different endocytic behaviour of Chs3 during budding or hyperpolarized growth in yeast cells

Yeast cells normally grow by budding, but under certain specific conditions they are also able to grow in hyperpolarized forms reminiscent of hyphal growth. During vegetative growth, the synthesis of the septum that physically separates yeast cells during cytokinesis depends on the correct assembly of the septin ring. Septins and actin patches are assembled at the neck, forming two concentric rings where the actin patch ring occupies the external‐most part. This specific positioning defines a plasma membrane region at the neck from which other lateral membrane compartments are excluded. In this scenario, correct assembly of the chitin ring is dependent on the anchoring of Chs3 to the septin ring through Chs4. The anchoring of Chs3 to septins through Chs4 prevents the arrival of this protein at endocytic sites, thus reducing the endocytosis of Chs3. This allows an equilibrium to be set up between the antero‐ and retrograde transport of Chs3, facilitating the synthesis of the chitin ring at the neck. In contrast, hyperpolarized growth is characterized by a reduced endocytic turnover of Chs3, which in turn lead to the accumulation of Chs3 at the plasma membrane and a concomitant increase in chitin synthesis.
ANALISIS FAKTOR YANG MEMENGARUHI PETANI MEMILIH POLA TANAM UBI KAYU SERTA EFISIENSI TEKNIS DI KABUPATEN LAMPUNG TENGAH

Rendahnya produksi singkong mengharuskan Indonesia mengimpornya dari negara lain. Upaya untuk meningkatkan produksi dan produktivitas perlu dilakukan untuk mengatasi masalah ketersediaan domestik. Teknologi budidaya ubi kayu diharapkan dapat membantu dalam meningkatkan produksi. Penelitian ini bertujuan untuk menganalisis faktor-faktor yang mempengaruhi petani singkong untuk memilih pola tanam dan efisiensi teknis di Lampung. Metode analisis yang digunakan untuk mengukur faktor-faktor yang mempengaruhi pola tanam dan Data Envelopment Analysis (DEA) untuk mengukur tingkat efisiensi petani. Data primer digunakan melalui wawancara kuesioner, dan data sekunder diperoleh dari institusi. Hasil penelitian menunjukkan bahwa ada 4 variabel signifikan yang mempengaruhi pola tanam petani yaitu luas lahan, jarak lahan dengan pabrik, pendapatan sedangkan variabel tingkat pendidikan tidak berpengaruh signifikan. Jika diukur seara teknis bahwa petani tumpangsari lebih efisien dibandingkan petani monokultur dengan persentase 77.41 dan 45.
Intra‐arterial therapy of melanoma with dimethyl triazeno imidazole carboxamide (NSC‐45388)

NTKA-ARTERIAL I N F U S I O N T H E R A P Y IS A I method of delivering a high concentration o f an effective antitumor drug to a localized tumor, all portions of which are perfused by a single accessible arterial supply.8 Dimethyl I.ri;izeno imiclazole carboxamitle (DTZC, NSC 45388) is a synthetic antitumor agent of unk n o i v n mode of action which, given intrawnously, gives rise to approximately 20% rcmiscions in patients with disseminated malignant melanoma. '~3~6~Q This is a higher remission rate than has generally been reported for other agents.5 T h e drug is not locally irritating to vessels, and this is in its favor as an ;gent lor intra-arterial infusion. The fact that c~uadrupling the intravenous dose does not seem to increase the response rate is a point against i t as a potential intra-arterial infusion agent, since this suggests that there might be little point in presenting the melanoma cells with the still greater concentrations of drug possililc by infusion.
Community growth monitoring in practice

For some, football is more a religion than a sport. This can impact on families in multiple ways. One such quasi-religious event was the UEFA Cup Final between Glasgow Celtic and Porto (21 May 2003). An estimated 85 000 Celtic supporters converged on Seville for the UEFA Cup Final. While doing two paediatric clinics on the day of the Cup Final I noted that the “did not attend” (DNA) rate at these clinics was well above normal, being …
The Labeling Effect of a Child Benefits System: Evidence from Russia 1994-2015

Impacts of child benefits and earned incomes on child wellbeing are identified for Russia. To predict earnings, a counter-factual commodity price model is constructed using information on local industrial composition and the evolution of world prices during 1994-2015 for six key commodity exports. Discontinuity in benefits eligibility at age 16 is exploited to predict the probability of receipt. Child benefits are found not to be spent differently from earned incomes or to influence child health differentially. Benefits do not observably crowd out private transfers to households containing children. Earned incomes and child health appear to be little related.
Maintaining reliability through activity management in an 802.15.4 sensor cluster

Different ways to simultaneously control event sensing reliability and device utilization in a beacon-enabled IEEE 802.15. 4 sensor cluster are investigated. Activity management is achieved through probabilistic control of the duration of active and inactive (i.e., service and sleep) periods. The probabilistic control parameters are derived as functions of the required event sensing reliability, device utilization, medium access control and physical layer parameters, and network size
Wearing Two Hats: CEO Duality, Risk, Innovation, and Firm Performance in the IT Industry

The relationship between the role of the CEO, and corporate risk, innovation, and performance, has been explored in prior literature. However, a majority of the research takes an agency view of the role of the CEO, considering CEO compensation as a major factor in organizational outcomes. Empiric results have been mixed, and sometimes, contradictory. The role of the CEO in relation to firm outcomes is especially complex in the information technology industry. We propose a model rooted in stewardship theory, which adopts a behavioral rather than an economic view of the CEO, to explain how CEOduality is linked to corporate risk, innovation
Manual-based group psychotherapy for bipolar disorder: a feasibility study.

BACKGROUND The Life Goals Program is a structured, manual-based group psychotherapy program for bipolar disorder that seeks to improve patient participation in medical model treatment (phase 1) and assist patients in meeting functional status goals (phase 2). The goals of this initial study were (a) to determine whether the procedures could be exported from the authors to other therapists and (b) to quantify tolerability and impact of procedures on patients. METHOD Four therapists across 2 sites and 29 patients from the Veterans Affairs (VA) Medical Center were studied in an open feasibility study. Therapists were trained, and subsequent compliance with manual procedures was quantified. Several process indices measuring tolerability and impact on patients were analyzed. RESULTS Therapists covered 90% to 96% of phase 1 psychoeducational content, indicating excellent fidelity to manual procedures. Sixty-nine percent of patients completed phase 1, and participation scores were in the good to excellent range for 56%. Completion of phase 1 was associated with significant increase in knowledge about bipolar disorder. Fourteen (70%) of 20 patients enrolled in phase 2 reached their self-identified, behaviorally based goal (48% of the total sample who began phase 1 of the program). Mean +/- SD time to goal completion was 8.7 +/- 5.3 months (median [95% confidence interval] = 7 [5.1-12.3 months]; range, 2-17 months). CONCLUSION The manual-based intervention can be exported with fidelity to other therapists and sites (for phase 1). Data indicate reasonable tolerability and good achievement of process (for phases 1 and 2) for those who accept this group modality. Comparison with other manual-based psychotherapies indicates remarkable consistency regarding content for psychotherapy for bipolar disorder; major differences among the psychotherapies include mode of delivery and relative emphasis of specific components.
Effect of experiential marketing on purchase intention: a moderated mediation of store image and perceived value among selected supermarkets in Nairobi; Kenya.

The experience economy is right here; characterised by high levels of competition and assertive customers who make purchase decisions guided by their rational and emotional influences. Moreover, customers are value driven and get attracted by outlets that project positive images. There has however been no known empirical research that has modelled this complex relationship. The purpose of this study was therefore to determine the relationship between experiential marketing and purchase intention, moderated and mediated by store image and perceived value. The study was grounded on the Theory of Planned Behavior, Pine & Gilmore model of experience economy, and the Stimulus Organism Response model. Quantitative and explanatory research designs guided the study. Data for the study was collected from a sample of 420 customers from the Nairobi city based branches of three tier one retail Chains in Kenya namely Nakumatt, Tuskys and Naivas. Store intercept method was used to purposefully identify the study respondents and a questionnaire used to collect data. Data was tested to ensure that it conforms to the regression assumptions and later analyzed using descriptive and inferential statistics. Confirmatory factor analysis and structural equation modeling (SEM) was used for data analysis, using the software‘s; SPSS, SPPSS with process macro model 7. Relationships were tested based on the dimensions and not the first order constructs. Multiple hierarchical regression analysis was used in determining the regression model with the overall efficiency of the model determined by use of coefficient of determination (R 2 ). The results of the study showed that all the direct and indirect (mediated) relationships were statistically significant. Moreover, bootstrapping results indicate that only three out of six conditional indirect effects were statistically significant; those involving social-sensory experience and social value (β=0.0245: Btll 0.0045, Btul 0.0516), emotional experience and utilitarian value (β=0.0506; Btll 0.0045, Btul 0.1075), and, emotional experience and social value (β=0.0628: Btll 0.0282, Btul 0.1099). These results confirm perceived value dimensions (social, utilitarian and hedonic) as mediators in relationships directed at purchase intention while store image also emerged as a moderator in these relationships. The study has contributed to theory by successfully developing and testing an integrated model on consumer decision making. In addition, a new variable social-sensory experience has emerged from this study. The study recommends that supermarket package their strategies to incorporate the shoppers‘ emotional and social-sensory experiences as well as value propositions that emphasises rational, social and hedonic aspects. Moreover, store personnel should be well trained on service and product knowledge. Future studies may test the model in an online or a non-service sector.
Prognostic influence of elevated values of cardiac troponin I in patients with unstable angina.

BACKGROUND Elevations of the MB isoform of creatine kinase (CK) and cardiac troponin T seem to confer an adverse prognosis in unstable angina. We examined whether this prognostic influence is also present for cardiac troponin I (cTnI), a new and even more specific marker of myocardial injury. METHODS AND RESULTS We studied 106 patients with the clinical diagnosis of unstable angina showing chest discomfort at rest within 48 hours of admission, ECG evidence of myocardial ischemia, and normal values of total CK over the initial 16 hours of observation. The primary end point was death or nonfatal myocardial infarction (MI) at 30 days; the secondary end point was the incidence of cardiac events at 1 year. Blood was drawn every 8 hours for 3 days. Thirteen patients were excluded because of increased CK-MB mass concentrations within 16 hours of admission (non-Q-wave MI) and 2 because of inadequate blood sampling. Of the remaining 91 patients, 22 had cTnI elevations on admission (n=7) or after 8 hours (n=15). At 30 days, no deaths (0%) and 4 MIs (5.8%) occurred in the 69 patients with normal cTnI compared with 2 deaths (9.1%) and 4 MIs (18.2%) in the 22 patients with elevated cTnI. The combined incidence of death and nonfatal MI was 5.8% and 27.3%, respectively (P=.02). At 1 year, only 68% of patients with elevated cTnI were free of cardiac events, compared with 90% of those without elevations (P=.01). CONCLUSIONS These data indicate that cTnI is an important prognostic variable in patients with unstable angina. Elevations of cTnI predict an adverse short- and long-term prognosis.
Effects of dietary enrichment with conventional foods on energy and protein intake in older adults: a systematic review.

CONTEXT Decreased food intake is a common problem among older adults; it is a known cause of weight loss and may lead to malnutrition. OBJECTIVE The objective of this systematic review was to determine the effects of dietary enrichment with conventional foods on energy and protein intake in older adults. DATA SOURCES Studies were identified through systematic searches of the following electronic databases: MEDLINE, via PubMed; CINAHL, via EBSCO; Web of Science; Scopus; and Google Scholar. STUDY SELECTION Studies in older adults were included without restrictions for sample size, length of follow-up, comparators, or date or status of publication. Eligible studies were dietary-enrichment interventions with conventional foods and powdered modules that aimed to increase the energy and protein density of meals without significantly increasing the final volume of the meals. DATA EXTRACTION Outcomes assessed included changes in energy intake, protein intake, nutritional status, body weight, functional status, and episodes of infection. DATA SYNTHESIS Nine studies were included. The results suggest that dietary enrichment can improve energy intake in older adults. While dietary enrichment seems to increase protein intake, there is not enough evidence of sufficient quality to confirm this observation or to determine whether dietary enrichment improves other outcomes assessed in this population. CONCLUSIONS Additional large clinical trials with long-term interventions are needed to establish the effects of dietary enrichment in older people at risk of malnutrition.
Patterns in Effective Distributed Software Development

As with many other industries today, software development must increasingly adapt to teams whose members work together but are geographically distributed. Many factors have contributed to this rise in distributed software development (DSD), including companies' desires to leverage skilled resources wherever they can be found and to reduce costs by working in different labor markets. Its increasing popularity has led to diverse industrial experience, which has in turn led to some best practices and an initial body of knowledge.
Quantitative proteomic analysis of the budding yeast cell cycle using acid‐cleavable isotope‐coded affinity tag reagents

Quantitative profiling of proteins, the direct effectors of nearly all biological functions, will undoubtedly complement technologies for the measurement of mRNA. Systematic proteomic measurement of the cell cycle is now possible by using stable isotopic labeling with isotope‐coded affinity tag reagents and software tools for high‐throughput analysis of LC‐MS/MS data. We provide here the first such study achieving quantitative, global proteomic measurement of a time‐course gene expression experiment in a model eukaryote, the budding yeast Saccharomyces cerevisiae, during the cell cycle. We sampled 48% of all predicted ORFs, and provide the data, including identifications, quantitations, and statistical measures of certainty, to the community in a sortable matrix. We do not detect significant concordance in the dynamics of the system over the time‐course tested between our proteomic measurements and microarray measures collected from similarly treated yeast cultures. Our proteomic dataset therefore provides a necessary and complementary measure of eukaryotic gene expression, establishes a rich database for the functional analysis of S. cerevisiae proteins, and will enable further development of technologies for global proteomic analysis of higher eukaryotes.
Is there increase of STDs during Carnival? Time series of diagnoses in a STD clinic.

OBJECTIVE Sexually transmitted diseases (STDs) are common reasons for seeking medical assistance. Media campaigns on STD/AIDS assume that exposure to risky sexual practices is greater during Carnival. The objective of this study was to analyze the temporal distribution of first appointments in a STD clinic from January 1993 to December 2005 to verify whether there is a seasonal increase in STD after Carnival. METHODS A total of 2,646 medical records with a diagnosis of gonorrhea, syphilis, or trichomoniasis were selected among patients seeking medical assistance in the STD Unit of Universidade Federal Fluminense, Niterói, Rio de Janeiro, Brazil. Statistical analysis was performed using month-to-month and year-to-year standardized average number of appointments during 13 years, in addition to smoothed time-series data using the Lowess method and the deterministic moving average method. RESULTS July and August exhibited the largest number of gonorrhea and syphilis diagnoses, and June and July of trichomoniasis diagnoses. Gonorrhea had its peak value in May, with a falling trend until August. A constant number of syphilis diagnoses was observed between May and August, with smaller numbers in January and February and peak values in November. The seasonal pattern for trichomoniasis diagnosis showed peak values in July, with a consistent falling trend until December and an increase from January on. CONCLUSION Carnival has no influence on the increase in the occurrence of gonorrhea, syphilis, and trichomoniasis in patients attending a STD clinic in Niterói, Rio de Janeiro, Brazil.
Coronary revascularisation in stable patients after an acute coronary syndrome: a propensity analysis of early invasive versus conservative management in a register-based cohort study

Objectives To compare the effectiveness of in-hospital medical therapy versus coronary revascularisation added to medical therapy in patients who stabilised after an acute coronary syndrome (ACS). Design Propensity score-matched cohort study from the database of the Tampere ACS registry. Setting A single academic hospital in Finland. Participants 1149 patients with a recent ACS, but no serious coexisting conditions: recurrent ischaemic episodes despite adequate medical therapy, haemodynamic instability, overt congestive heart failure and serious ventricular arrhythmias. Primary and secondary outcome measures The composite endpoint of major acute cardiovascular events (MACEs): unstable angina requiring rehospitalisation, stroke, myocardial infarction and all-cause mortality, at 6-month follow-up. Results Compared with standard medical treatment, revascularisation was associated with a lower rate of MACEs at 6 months in patients of the first quintile (HR 0.81; 95% CI 0.66 to 0.99), but a higher rate of MACEs in the fifth quintile (HR 4.74, CI 1.36 to 16.49; p=0.014). There were no significant differences in the rates of MACEs in the remaining three quintiles. Patients of the first quintile were the oldest (79.7±8.3 years) and had a more significant (p<0.001) history of prior myocardial infarction (37%) and poor renal function (creatine, µmol/l: 114.9±70.7). They also showed the highest C reactive protein (7.3±9.5 mg/l) levels. Conclusions Our findings suggest that in-hospital coronary revascularisation did not lead to any advantage with signal of possible harm in the great majority of patients who stabilised after an ACS. An early invasive management strategy may be best reserved for elderly patients having high-risk clinical features and biochemical evidence of a strong inflammatory activity.