Miracle-dz/UniFAR-FTUs huggingface dataset:
Diaphragmatic plication for iatrogenic respiratory insufficiency after cardiothoracic surgery.

Background The efficacy of diaphragmatic plication (DP) has been proven in many studies. However, there are few reports on DP for patients with severe respiratory conditions requiring mechanical ventilation. The study aim was to demonstrate the efficacy of DP for patients with severe respiratory insufficiency after cardiothoracic surgeries. Methods We retrospectively reviewed 10 patients who underwent DP for severe respiratory insufficiency due to postoperative diaphragmatic paralysis; eight of them required mechanical ventilation, and two needed high-flow oxygen therapy prior to DP. The symptoms, lung function, and elevation of the diaphragm were assessed before and after DP. Results All patients were successfully withdrawn from mechanical ventilation after DP and discharged without the need for oxygen therapy. The mean perioperative Medical Research Council (MRC) dyspnea scale (ATS/ERS 2004) score improved in 30 days (from 4 to 1.8) and in 90 days (from 4 to 0.6) after DP. Lung dynamic compliance was also ameliorated (mean improvement: 41.9 to 60.7 mL/cmH2O). Radiography revealed improved elevation of the diaphragm (mean improvement of 1.8 intercostal spaces, range, 1-2). Mean hospital stay after DP was 65.5 days (range, 25-187 days). One patient who underwent DP with endostapler-only suturing required re-operation because of staple line ruptures. Conclusions DP was found to be an effective form of treatment for patients with severe respiratory insufficiency after cardiothoracic surgery.
Light and Life at Night as Circadian Rhythm Disruptors

The axial rotation of the Earth, together with the light of the sun, generates 24-hour cycles of day and night, and this light-dark cycle is the basis of 24-hour circadian rhythms. Living organisms have their own endogenous circadian rhythms, also with a duration of approximately 24 hours, driven by environmental factors, especially light and darkness [1]. And it is widely known that circadian rhythms of mammals are regulated by an internal biological clock located in the suprachiasmatic nuclei (SCN) situated directly above the optic chiasm [2]. Maintaining the biological clock is crucial for coordinated function throughout the human body because this near-24-hour oscillations are found in essentially every physiological process in the human brain and body [3,4]. The period, phase and amplitude of circadian rhythms can be affected by circadian gene variants, light exposure, social cues, meal times and work schedules [5-8]. Light is the most effective Light and Life at Night as Circadian Rhythm Disruptors
Systems analysis of barrier molecule and ARNT-related gene expression regulation in melanoma

ABSTRACT Background: We have identified, in melanomas, a set of genes encoding proteins that mediate mechanical barrier function in normal skin (barrier molecule genes, BMGs) and whose overexpression is associated with decreased immune signatures and shorter patient survival. The most overexpressed of these, filaggrin (FLG), is expressed on chromosome 1q21.3, which also encodes genes of the epidermal differentiation complex (EDC). EDC genes may be regulated by the transcription factors (TFs) AHR and ARNT. We hypothesized that ARNT-related genes would be expressed concordantly with BMG and EDC genes, inversely associated with immune signatures, and enhanced by 1q21.3 copy gain. Methods: Gene expression data from human melanomas in the Cancer Genome Atlas (TCGA), and a validation GEO dataset were evaluated, with copy number profiles from TCGA. Expression of Th1 immune genes and BMG/EDCs at 1q21.3 was visualized using clustered copy number and mRNA profiles. Associations of clusters and 1q21.3 copy number with patient survival and mRNA expression were assessed using Kaplan Meier curves, log-rank tests, and Wilcoxon rank sum tests. Results: BMGs are concordantly expressed with EDC genes. Clustering divided tumors into 4 categories: (1) ImmuneHI, (2) BMG/EDCHI, (3) ARNTHI, (4) Mixed. Both ARNTHI and BMG/EDCHI tumors had low immune signatures and significantly shortened survival. KLF4 and FOXF2 are putative TFs that may regulate these genes. Conclusions: ARNTHI tumors may represent another subset of tumors, in addition to BMG/EDCHI tumors, with barriers to immune infiltrates, likely with different mechanisms. These genes have prognostic significance and may be relevant targets for future therapy.
Development of Simple Multiple-Choice Diagnostic Test of Acid-Base Concepts to Identify Studentsr Alternative Conceptions

Alternative conception is students' conception of scientific concepts that are inconsistent with the conception of scientists. Various studies show that alternative conceptions of chemical concepts occur in students, including acid-base concepts. Various identification of alternative conception methods have also been developed, including a simple multiple-choice diagnostic test. Although not too accurate, simple multiple-choice diagnostic test is easy to develop, use, and analyze, but useful enough to identify students’ alternative conceptions. The aims of the study are to develop a valid and reliable simple multiple-choice diagnostic test instrument of acid-base concepts and to identify alternative conceptions of 11 grade students and first year university students of Chemistry Program. This descriptive research design was conducted in two stages 1) development of valid and reliable of simple multiple-choice diagnostic test of acid-base concepts and (2) identification of students’ alternative conceptions. Analysis of instrument validity and reliability was performed based on response of 184 students of 11 grade students and 133 first year university students of Chemistry Program who had studied acid-base concepts before. While the identification of students’ alternative conceptions was conducted to 59 students of 11 grade and 40 first year university students of Chemistry Program. Analysis to response of 11 grade students indicate that 8 of the 25 test items of the acid-base concepts developed in this research were invalid. Five invalid items that have a negative or very low Pearson correlation coefficient were removed, the rest having better Pearson correlation coefficient refined and used to identify students’ alternative conception. The final version of the instrument has a Cronbach’s alpha reliability of 0.537 (medium grade) for 11 grade students and 0.470 (upper low grade) for first year university students. The results of the data analysis show that the alternative conceptions of acid-base concepts occurring in the 11 grade students are more extent and intense than that occurs in the first year university students of Chemistry Program. These can be caused by the difference of age, concept ecology, learning motivation, learning fidelity, and discipline background between 11th grade students and first year university students of Chemistry Program. Keywordsdiagnostic test, alternative conception, acid-base concepts, simple
Acute abdominal pain causes in patients referred to hospital treatment

Objective. Acute abdominal pain is the most common complaint to visit the emergency room. It can be caused by a wide range of underlying surgical and non-surgical conditions. These patients need a quick assessment because of the probability of conducting surgery. The aim of this study was to evaluate the frequency distribution of acute abdominal pain reason and its relation to age, underlying disease and sex. Methods. This descriptive cross-sectional study was conducted on 352 patients with acute abdominal pain in Shahid Sadoughi hospital. Data were extracted from medical records. Diagnosis of disease was performed by a physician. Results. The most common underlying disease in patients with acute abdominal pain was hypertension (14.8%) and diabetes mellitus (10.8(%. The most common cause of disease was related to abdominal pain without any cause (32.2%), intestinal obstruction (14.8%), appendicitis (13.1%), cholecystitis (11.1%) and lead poisoning (4%). The most frequent symptoms in these patients were nausea (49.7%), vomiting (48.6(%, persistent pain (61.6(% and reduced appetite (49.7%). There was a significant difference between the frequency distribution of acute abdominal pain causes in terms of age, sex, job and marital status (p<0.05). Conclusion. The most common cause of acute abdominal pain was related to intestinal obstruction, appendicitis and cholecystitis. The prevalence of appendicitis and intestinal obstruction was higher in young and old patients, respectively. Moreover, cholecystitis and intestinal obstruction were more common in women and men, respectively. It seems that some parameters including age, sex, job and marital status may be key factors that affect acute abdominal pain.
Bridging Remote Cultures : Influence of Cultural Prior-Knowledge in Cross-Cultural Communication (人工知能学会全国大会(第26回)文化,科学技術と未来) -- (International Organized Session「Alan Turing Year Special Session on AI Research That Can Change The World」)

The role of ontology in a multilingual context is one of the emerging challenges in our modern information society. This work first explains different types of ontology applications in a multilingual context based on a number of dimensions defined in [Cimiano 2010]. These dimensions are useful for clarifying the role of ontologies depending on different types of cross-cultural communication scenarios. What is emphasized here is a new dimension in the ontology applications, namely the inherent asymmetric relation of communication between a communicator and an information receiver, which has been inspired by the pragmatic approach of the so-called Relevance Theory of Communication (RTC) [Sperber 1986]. Based on this ground theory, a new framework for simulating the cognitive processes involved in a cross-cultural communication is proposed.
Temporal Trends in Chronic Total Occlusion Percutaneous Coronary Interventions: Insights From the PROGRESS-CTO Registry.

BACKGROUND Chronic total occlusion (CTO) percutaneous coronary intervention (PCI) has significantly evolved in recent years. METHODS We compared the clinical, angiographic, and technical characteristics, as well as procedural outcomes of CTO-PCIs in a multicenter registry between the "early era" (2012-2016) and the "current era" (2017-2019). RESULTS Current era patients more often had stage III or IV angina compared with early era patients (71% vs 66%, respectively; P=.03) and were less likely to undergo ad hoc CTO-PCI (13% vs 16%, respectively; P=.04). The J-CTO score was slightly lower in the current era patients vs the early era patients (2.3 ± 1.4 vs 2.5 ± 1.3, respectively; P=.04). Use of antegrade wire escalation increased in the current era (92% vs 83% in the early era patients; P<.001) whereas use of retrograde crossing decreased (29% vs 39% in the early era; P<.001) and antegrade/ dissection re-entry decreased (23% vs 32% in the early era; P<.001). Technical success rates (85% in the current era vs 86% in the early era; P=.69) and procedural success rates (83% in the current era vs 85% in the early era; P=.15) were similar, whereas the incidence of in-hospital major cardiovascular events decreased in the current era (2% vs 3% in the early era; P=.04). CONCLUSIONS During recent years, ad hoc CTO-PCI decreased along with decreasing use of retrograde crossing and antegrade dissection and re-entry. Technical and procedural success rates remained stable, whereas the incidence of in-hospital MACE decreased.
Psychotropic Drugs in Anorexia Nervosa: Waiting for Clear Evidence from Randomized Controlled Trials

AN has the highest mortality rate among all psychiatric illnesses, with a standardized mortality ratio of 5.86 [2]; one in five deaths in AN patients is by suicide [2]. In fact, regarding psychiatric comorbidity, AN patients often present mood disorders, anxiety disorders and obsessive-compulsive symptoms [3]. Furthermore, obsessive thoughts regarding body shape and weight can become delusional and AN patients can be completely unaware of the altered way they perceive their own body [1]. Some authors demonstrated higher rates of psychiatric comorbidity and self-injurious or suicidal behavior in the binge-purging subtype, when compared with the restrictive subtype [4].
Dietary Pattern in Patients with Preeclampsia in Fasa, Iran

Background: Preeclampsiaisoneof thecausesof mortalityandhigh-riskpregnanciesthatendangersthehealthof mothersinthe developing countries. Objectives: The current study aimed at investigating the nutritional pattern in women with preeclampsia. Methods: Thecurrentcrosssectionalstudywasconductedon182pregnantwomen(82patientswithpreeclampsiaand100healthy subjects)selectedusingeasysamplinginFasaVali-e-AsrHospitalin2016. Thedietaryintakewasevaluatedusingasemi-quantitative food frequency questionnaire and the intensity of day-night activities by a physical activity questionnaire. Anthropometric indica-torswerecalculatedaccordingtostandardguidelines,measurement,andbodymassindex. Dietarypatternswerecharacterizedby a factor analysis and its relationship with preeclampsia was investigated by logistic regression method. Results: Two unhealthy and healthy dietary patterns were identiﬁed among individuals. In the crude model and after adjusting theeﬀectof confoundingvariablesof unhealthydietarypatterns,nosigniﬁcantrelationshipwasobservedbetweendietarypattern and preeclampsia. In the fourth compare to the ﬁrst quartile of the healthy dietary pattern, the chance of preeclampsia was 0.219 (95% CI: 0.090 - 0.528, P = 0.001) crude model and 0.178 (95% CI: 0.059 - 0.530, P = 0.002) adjusted model. Conclusions: The ﬁndings indicated that choosing a healthy dietary pattern was associated with a reduction in the risk of preeclampsia. Regarding these results, prevention of preeclampsia maybe possible by the healthy diet recommendation. The oc-currence of complications in the mother, the fetus, and the baby in the future can also be prevented through the same way.
Path Analysis on the Factors Affecting Postnatal Depression

Background : Postpartum depression is one of the emotional disorders as a result of failure to accept the psychological adaptation process in women in the postpartum period. There are many factors of postpartum depression. This study aimd to determine factors affecting postpartum depression. Subjects an d Met h od: This was a cross sectional study conducted at 30 villages, in Bantul, Yogyakarta, from February to March 2019. A sample of 210 postaprtum mothers was selected by purposive sampling. The dependent variable was the postpartum depression. The independent variables were age, education, income, ANC visit, number of children, parity, unwanted pregnancy, type of labor, family support, domestic violence, and stress. Postpartum depression was measured by Endinburgh postnatal depression scale. Psychological stress was measured by Kessler psychological distress scale. The other variables were collected by questionnaire. The data was analyzed by path analysis. Results : Postpartum depression was directly and positively affected by type of labor (b = 3.85; 95% CI= 0.16 to 7.54; p = 0.041), stress (b= 3.53; 95% CI= 0.34 to 6.72; p= 0.030), parity (b= 4.01; 95% CI= 0.04 to 7.98; p= 0.048), unwanted pregnancy (b= 9.43; 95% CI= 1.51 to 17.3; p= 0.019). It was directly and negatively affected by number of children (b = -5.05; 95% CI= -10 to -0.02; p = 0.049), family support (b= -3.73; 95% CI= -6.98 to -0.50; p= 0.024), and ANC visit (b = -8.18; 95% CI= -15.3 to -1.00; p= 0.026). Postpartum depression was indirectly affected by education, income, domestic violence, and age. Conclusio n: Postpartum depression is directly and positively affected by type of labor, stress, parity, unwanted pregnancy. It is directly and negatively affected by number of children, family support, and ANC visit. Postpartum depression is indirectly affected by education, income, domestic violence, and age. Keywords : Postpartum depression, domestic violence, path analysis Cor r esponden ce : Sri Widarti. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: widacorset@gmail.com. Mobile: 082135814923. Journal of Maternal and Child Health (2019), 4(5): 358-368 https://doi.org/10.26911/thejmch.2019. 04.05. 10
Analysis of stress distribution in ceramic and titanium implants in alveolar sockets of the anterior region of the maxilla

Background In the routine of dentistry, knowing the biomechanical properties of implant systems and their inherent stress distribution under force loading is an essential step to predict structural damage and biological responses. This study aimed to investigate stress distribution in zirconia and titanium implants and their biomechanical response in alveolar sockets of the anterior region of the maxilla through tridimensional finite element analysis. Material and Methods From computed tomography scans of a reference patient, three models of the maxillary dental arch were designed with Rhinoceros 5.0 software (McNeel Europe™, Barcelona, Spain). In each model, a dental implant replaced the maxillary left central incisor. The implants consisted of M1) Zirconia Pure Ceramic Implant Monotype; M2) Zirconia Pure Ceramic ZLA; and M3) Titanium Bone Level - Roxolid SLA. Ceramic crowns were installed in all the implants. Implants and prostheses were loaded with 50N oblique and axial forces. Von-Mises and Mohr Coulomb criteria were used to assess stress distribution in the implant systems and perimplantar bone, respectively. Results Traction was detected in the cervical region of the palatal bone surface of all the models. Oppositely, compression was found in the cervical region of the vestibular bone surfaces. Conclusions Zirconia Pure Ceramic Implant Monotype had the best response under oblique force loading. Ceramic implants may be an alternative to replace titanium implants in fresh alveolar sockets in the anterior region of the maxilla. Key words:Finite elements, implants, stress, ceramic, titanium.
Interdependence of oxidative/antioxidant system indicators and thyroid status under conditions of prolonged exposure to small doses of radiation

We have studied the interdependence of the intensity of oxidative processes/antioxidant level and the thyroid status parameters in a group of students aged 18–24 who lived for a long time in the territory of enhanced radioecological control (density of soil contamination by isotopes (137Cs 3.7 ∙ 104 – 18.5 ∙ 104 Bq/m2). We examined 50 people from relatively environmentally friendly areas (control group) and 50 people from IV radiation zone (experimental group). In the experimental group, there were no individuals with clinical manifestations of thyroid pathology. However, subgroups with signs of hyperthyroidism and hypothyroidism were identified. We evaluated the level of cortisol, thyrotrophic hormone (TSH), triiodothyronine (T3), thyroxine (T4), malonic dialdehyde (MDA), ceruloplasmin (CP), transferrin (Tf), sulfhydryl groups (SH); we calculated the oxidative stress index (OSI). The research was conducted one month before the examination time and also during the exams as a factor in increased emotional stress. A lowered CP level was found in the subgroup with signs of hypothyroidism; SH groups – in all subgroups, separated by thyroid status. The oxidative stress index was higher in all students examined of the experimental group, compared with the control. The growth of MDA level is marked in the experimental group – it is the most strongly pronounced in conditions of additional emotional load in people with signs of hyperthyroidism and hypothyroidism. CP level significantly decreased in the subgroup of hyperthyroidism on the background of T3 decrease. OSI increased in all students examined from the experimental group. In the subgroup of hypothyroidism it became significantly higher than in the subgroup of euthyroidism. A positive correlation between the levels of CP and T3 was found. The highest values of the correlation coefficients were noted for subgroups with signs of hyperthyroidism and hypothyroidism, with the coefficient significance increasing under conditions of emotional stress. The index of oxidative stress in the experimental group positively correlated with the level of TSH – in terms of emotional stress, the statistical significance of the coefficients disappeared. In the subgroups divided by thyroid status, variability of interactions between OSI and T3 was observed but it was not statistically significant. It was found that the participation of thyroid status in supporting redox homeostasis in people aged 18–24 who suffered from chronic small-doze radiation exposure was realized mainly by the influence on the antioxidant system. The ability of thyroid hormones to maintain a proper antioxidant state was suppressed in this group. The unbalanced relationship between thyroid hormones and oxidative stress indicators is strongly manifested under conditions of additional emotional stress.
Interleukin 28B Polymorphism as a Predictor of Response to Treatment of Egyptian HCV Patients Working in Nuclear Material Authority

Background: A Single nucleotide polymorphism upstream of the interferon-λ3 gene (IFNL3; formerly referred to IL28B), strongly linked to unprompted and treatment-induced HCV infection clearance. Interleukin 28B genotype predictive value over the outcome interferon-α/ribavirin treatment was assessed carefully and contrasted with virological predictors Objective: The study aimed to evaluate IL-28B rs12979860 polymorphism in the reaction of HCV patients with directacting antiviral (DAA) regimens (sovosbuvir) and ribavirin therapy and the allele frequencies of this gene in Egyptian HCV patients working in the Egyptian Nuclear Materials Authority contrasted to healthy control. Subjects and Methods: The study was conducted on randomly chosen fifty Egyptian patients infected with genotype 4 HCV aged 30 or more and received antiviral therapy (sovosbuvir and ribavirin) before six months or more. Another Fifty age and gender matched apparantely healthy individuals were also selected as a control group. The study was carried out in accordance with the ethical principles and guidelines of the Declaration of Helsinki and a written informed consent was obtained from all subjects. Results:IL-28B genotype CC was found in 34.6% of patients, while CT and TT genotypes were identified in 42.3 and 23.1% of patients, respectively. Forty (40%) patients achieved an SVR, whereas ten (20%) did not. Of the 40 patients with an SVR, 12 had genotype CC, 25 had genotype CT, and 3 had genotype TT. CT genotype patients has achieved considerably higher SVR rates (62.5%) compared with CC (30%) and TT patients (7.5%). Conclusion: Polymorphism Il-28B is an autonomous predictor of SVR to Peg IFN / RBV in patients with genotype 4 in Egyptian HCV favorable.