Miracle-dz/UniFAR-FTUs huggingface dataset:
Zoledronic acid is superior to tenofovir disoproxil fumarate-switching for low bone mineral density in adults with HIV

Objective: To compare the effects of switching tenofovir disoproxil fumarate (TDF) or treatment with an intravenous bisphosphonate on bone mineral density (BMD) in HIV-positive adults with low bone mass. Design: Two-year, randomized, open-label study at 10 sites in Australia and Spain. Participants: Of 112 adults on TDF-based antiretroviral therapy (ART) screened, 87 with low BMD (T-score < −1.0 at hip or spine by dual-energy X-ray absorptiometry) and undetectable plasma HIV viral load were randomized to either switch TDF to another active antiretroviral drug or to continue TDF-based ART and receive intravenous zoledronic acid (ZOL) 5 mg annually for 2 years. Primary outcome measure: Change in lumbar spine BMD at 24 months by intention-to-treat analysis. Secondary outcomes included changes in femoral neck and total hip BMD, fractures, safety, and virological failure. Results: Forty-four participants were randomized to TDF switch and 43 to ZOL, mean age 50 years (SD 11), 96% men, mean TDF duration 5.9 years (SD 3.1), and mean spine and hip T-scores −1.6 and −1.3, respectively. At 24 months, mean spine BMD increased by 7.4% (SD 4.3%) with ZOL vs. 2.9% (SD 4.5%) with TDF-switch (mean difference 4.4%, 95% CI 2.6–6.3; P < 0.001). Mean total hip BMD increased by 4.6 (SD 2.6%) and 2.6% (SD 4%), respectively (mean difference 1.9%, 95% CI 0.5–3.4; P = 0.009). There was one fracture in the ZOL group vs. seven fractures in four TDF-switch participants. Virological failure occurred in one TDF-switch participant. Other safety endpoints were similar. Conclusion: ZOL is more effective than switching TDF at increasing BMD in HIV-positive adults with low bone mass.
Who Feels What and Why? Annotation of a Literature Corpus with Semantic Roles of Emotions

Most approaches to emotion analysis in fictional texts focus on detecting the emotion expressed in text. We argue that this is a simplification which leads to an overgeneralized interpretation of the results, as it does not take into account who experiences an emotion and why. Emotions play a crucial role in the interaction between characters and the events they are involved in. Until today, no specific corpora that capture such an interaction were available for literature. We aim at filling this gap and present a publicly available corpus based on Project Gutenberg, REMAN (Relational EMotion ANnotation), manually annotated for spans which correspond to emotion trigger phrases and entities/events in the roles of experiencers, targets, and causes of the emotion. We provide baseline results for the automatic prediction of these relational structures and show that emotion lexicons are not able to encompass the high variability of emotion expressions and demonstrate that statistical models benefit from joint modeling of emotions with its roles in all subtasks. The corpus that we provide enables future research on the recognition of emotions and associated entities in text. It supports qualitative literary studies and digital humanities. The corpus is available at http://www.ims. uni-stuttgart.de/data/reman .
Staphylococcus aureus in the nose and throat of Iowan families

Abstract The study objective was to determine the prevalence of Staphylococcus aureus colonisation in the nares and oropharynx of healthy persons and identify any risk factors associated with such S. aureus colonisation. In total 263 participants (177 adults and 86 minors) comprising 95 families were enrolled in a year-long prospective cohort study from one urban and one rural county in eastern Iowa, USA, through local newspaper advertisements and email lists and through the Keokuk Rural Health Study. Potential risk factors including demographic factors, medical history, farming and healthcare exposure were assessed. Among the participants, 25.4% of adults and 36.1% minors carried S. aureus in their nares and 37.9% of adults carried it in their oropharynx. The overall prevalence was 44.1% among adults and 36.1% for minors. Having at least one positive environmental site for S. aureus in the family home was associated with colonisation (prevalence ratio: 1.34, 95% CI: 1.07–1.66). The sensitivity of the oropharyngeal cultures was greater than that of the nares cultures (86.1% compared with 58.2%, respectively). In conclusion, the nares and oropharynx are both important colonisation sites for healthy community members and the presence of S. aureus in the home environment is associated with an increased probability of colonisation.
Age and Productivity - Evidence from Linked Employer Employee Data

In most Western, industrialised countries the workforce is ageing rapidly. In order to assess the possible consequences of an ageing workforce, this paper measures the impact of changes in the age structure of establishments on productivity using representative linked employer-employee panel data. We take into account that the levels as well as the changes in the age structure of establishments and their production are likely to be simultaneously determined and apply dynamic GMM methods. We find that establishment productivity increases with the share of employees until the age of 50-55 and only decreases slightly afterwards. Our findings suggest that previous estimations are biased because they either do not take into account endogeneity, time dependencies, or crucial information correlated with age shares and productivity. Large standard deviations point to important variation in the age productivity profile among establishments.
Body Weight and Mood State Modifications in Mixed Martial Arts: An Exploratory Pilot

Abstract Brandt, R, Bevilacqua, GG, Coimbra, DR, Pombo, LC, Miarka, B, and Lane, AM. Body weight and mood state modifications in mixed martial arts: An exploratory pilot. J Strength Cond Res 32(9): 2548–2554, 2018—Mixed martial arts (MMA) fighters typically use rapid weight loss (RWL) as a strategy to make competition weight. The aim of the present study was to compare body weight and mood changes in professional male MMA athletes who used strategies to rapidly lose weight (n = 9) and with MMA athletes who did not (n = 3). Body mass and mood states of anger, confusion, depression, fatigue, tension, and vigor and total mood disturbance were assessed (a) 30 days before competition, (b) at the official weigh-in 1 day before competition, (c) 10 minutes before competition, and (d) 10 minutes postcompetition. Results indicated that RWL associated with reporting higher confusion and greater total mood disturbance at each assessment point. Rapid weight loss also associated with high anger at the official weigh-in. However, in performance, RWL did not have deleterious effects on performance. The RWL group also reported greater total mood disturbance at all assessment points with a moderate difference effect size. Research supports the notion that RWL associates with potentially dysfunctional mood states.
Multiplex PCR Analysis for Rapid Detection of Klebsiella pneumoniae Carbapenem-Resistant (Sequence Type 258 [ST258] and ST11) and Hypervirulent (ST23, ST65, ST86, and ST375) Strains

Carbapenem-resistant and hypervirulent Klebsiella pneumoniae strains have emerged recently. These strains are both hypervirulent and multidrug resistant and may also be highly transmissible and able to cause severe infections in both the hospital and the community. ABSTRACT Carbapenem-resistant and hypervirulent Klebsiella pneumoniae strains have emerged recently. These strains are both hypervirulent and multidrug resistant and may also be highly transmissible and able to cause severe infections in both the hospital and the community. Clinical and public health needs require a rapid and comprehensive molecular detection assay to identify and track the spread of these strains and provide timely infection control information. Here, we develop a rapid multiplex PCR assay capable of distinguishing K. pneumoniae carbapenem-resistant isolates of sequence type 258 (ST258) and ST11, and hypervirulent ST23, ST65/ST375, and ST86 clones, as well as capsular types K1, K2, K locus type 47 (KL47), and KL64, and virulence genes rmpA, rmpA2, iutA, and iroN. The assay demonstrated 100% concordance with 118 previously genotyped K. pneumoniae isolates and revealed different populations of carbapenem-resistant and hypervirulent strains in two collections in China and the United States. The results showed that carbapenem-resistant and hypervirulent K. pneumoniae strains are still rare in the United States, whereas in China, ∼50% of carbapenem-resistant strains carry rmpA/rmpA2 and iutA virulence genes, which are largely associated with the epidemic ST11 strains. Similarly, a high prevalence of hypervirulent strains was found in carbapenem-susceptible isolates in two Chinese hospitals, but these primarily belong to ST23, ST65/ST375, and ST86, which are distinct from the carbapenem-resistant strains. Taken together, our results demonstrated that this PCR assay can be a useful tool for molecular surveillance of carbapenem-resistant and hypervirulent K. pneumoniae strains.
Titanium dioxide in dental enamel as a trace element and its variation with bleaching

Background Titanium is a less studied trace element in dental enamel. Literature relates an increased Titanium concentration with a decreased enamel crystal domain size, which in turn is related to a higher color value. The aim of our study was to analyze the effect of tooth bleaching agents on its concentration in dental enamel by means of confocal Raman spectroscopy. Material and Methods Human teeth were randomly distributed in six experimental groups (n=10) and submitted to different bleaching protocols according to the manufacturer´s instructions. Confocal Raman spectroscopy was carried out in order to identify and quantify the presence of titanium dioxide molecules in enamel prior to and during whitening. Statistical analysis included repeated measures analysis of variance (p≤0.05) and Bonferroni pairwise comparisons. Results Titanium dioxide concentration was negatively affected by the longer bleaching protocols (at-home bleaching gels). All in-office whitening products increased significantly the studied molecule (p≤0,05). Conclusions All dental specimens depicted the presence of titanium dioxide as a trace element in dental enamel. Bleaching gels that have to be applied at higher concentrations but for shorter periods of time increase the concentration of titanium dioxide, whilst at-home whitening gels used for longer periods of time despite the lower concentration caused a loss in titanium. Key words:Bleaching, whitening, hydrogen peroxide, carbamide peroxide, Raman spectroscopy, titanium dioxide.
Development and Validation of a Genomic Knowledge Scale to Advance Informed Decision-Making Research in Genomic Sequencing

Background: This study evaluated the psychometric properties of a new, comprehensive measure of knowledge about genomic sequencing, the University of North Carolina Genomic Knowledge Scale (UNC-GKS). Methods: The UNC-GKS assesses knowledge in four domains thought to be critical for informed decision making about genomic sequencing. The scale was validated using classical test theory and item response theory in 286 adult patients and 132 parents of pediatric patients undergoing diagnostic whole exome sequencing (WES) in the NCGENES study. Results: The UNC-GKS assessed a single underlying construct (genomic knowledge) with good internal reliability (Cronbach’s α = 0.90). Scores were most informative (able to discriminate between individuals with different levels of genomic knowledge) at one standard deviation above the scale mean or lower, a range that included most participants. Convergent validity was supported by associations with health literacy and numeracy (rs = 0.41–0.46). The scale functioned well across subgroups differing in sex, race/ethnicity, education, and English proficiency. Discussion: Findings supported the promise of the UNC-GKS as a valid and reliable measure of genomic knowledge among people facing complex decisions about WES and comparable sequencing methods. It is neither disease- nor population-specific, and it functioned well across important subgroups, making it usable in diverse populations.
Fundal pressure: risk factors in uterine rupture. The issue of liability: complication or malpractice?

Notre revue des publications judiciaires, qui inclut de nombreuses affaires judiciaires americaines et britanniques, montre que meme pour un uterus non dechire, le recours a l'expression abdominale expose les praticiens a un risque important de condamnation.
Utilization of struvite recovered from high-strength ammonium-containing simulated wastewater as slow-release fertilizer and fire-retardant barrier

ABSTRACT Sustainable uses of the struvite (magnesium ammonium phosphate hexahydrate, MgNH4PO4·6H2O, MAP) recovered from the synthetic wastewater, as a high-quality slow-release fertilizer for the growth of nine medicinal plants and a fire-retardant barrier on the flammability of cotton fabric and wooden plate, were explored in this study. The previous experimental results demonstrated that under the optimal conditions, about 98.7% of (initial = 1000 mg/L) could be effectively and successfully recovered from simulated wastewater in the form of MAP precipitate. Rates of increase in total fresh weights, total dry weights, and fresh heights of plants grown in soil fertilized with the struvite were determined as 67%, 52%, and 12% for valerian; 121%, 75%, and 18% for cucumber; 421%, 260%, and 47% for dill; 314%, 318%, and 27% for coriander; 432%, 566%, and 30% for tomato; 285%, 683%, and 26% for parsley; 200%, 225%, and 9% for basil; 857%, 656%, and 92% for rocket; and 146%, 115%, and 28% for cress, respectively, compared to the control pots. The microstructure, elemental composition, surface area, thermal behaviour, and functional groups of the grown crystals were characterized using SEM, EDS, BET, TGA-DTG-DSC, and FTIR analyses, respectively. Flammability tests and thermal analyses concluded that the dried and crumbled/implanted form of struvite used as a fire-retardant barrier demonstrated a remarkable flame-resistant behaviour for both cotton fabric and wooden plate. Findings of this experimental study clearly corroborated the versatility of struvite as non-polluting and environmentally friendly clean product for the sustainable usage in different fields GRAPHICAL ABSTRACT
Arbuscular mycorrhizal fungi mitigates NaCl induced adverse effects on Solanum lycopersicum L.

The present study aimed to investigate the effects of AMF on the growth and physio-biochemical attributes, antioxidant enzyme activities, plant growth regulators and inorganic nutrients in tomato grown under salt stress condition. Tomato plants were exposed to different concentrations of NaCl alone (0, 50 and 150 mM) and in combination with AMF (0mM+AMF, 50mM+AMF and 150mM+AMF). Spore population and colonization, growth and biomass yield, pigments, membrane stability index and malondialdehyde were negatively affected. Exposure of plants to combination of NaCl and AMF showed positive impact on the above parameters. Proline and antioxidant enzyme activity increased with increasing concentration of NaCl and further increase was observed in plants treated with NaCl in combination with AMF. Acid and alkaline phosphatase, hydrolytic enzymes and pectinase are also affected with increasing concentration of salt. However plants treated with NaCl in combination with AMF balances the above enzymatic activity. Salt stress decreases the auxin concentration in plants but application of AMF has been shown to restore the auxin content. ABA increases with salt concentration but less accumulation of ABA have been found in plants treated with AMF. Regarding the nutrient uptake, Na + and Na;K ratio increased and P, K, Mg and Ca decreases with increasing concentration of NaCl. Enhanced accumulation of P, K, Mg, Ca and K:N ratio and less uptake of Na + was observed in presence of AMF. The results confirm that NaCl imposes threat to the survival of tomato plants and application of AMF mitigates the negative effect to an appreciable level.
Synthesis and Antibacterial Studies of Metal Complexes of Cu(II), Ni(II) and Co(II) with Tetradentate Ligand

The new metal complexes of Cu(II), Ni(II) and Co(II) with the new ligand derived from isatine and 1,2-diaminocyclohexane were synthesized and biologically screened. The synthesized complexes and ligand were characterized by spectroscopic FT-IR, UV-VIS, 1H-NMR and elemental analyses. The ligand and complexes were screened for their antibacterial activities against three different strains, namely E. coli, P. aeruginosa and S. aureus. In particular, the Co(II) and Cu-complexes exhibited excellent antibacterial activities compared to the reference compound.
A case of Hodgkin's lyphoma which caused pericardial tamponade in a young female patient

Malign perikardiyal efuzyon (MPE), ileri evre maligniteli olgularin yaklasik %21’inde gorulur. Malign perikardiyal efuzyonun tedavisi icin standart bir yaklasim bulunmamaktadir. Bu yazida klinigimize perikardiyal tamponad ile basvuran 18 yasinda bir kadin olgu sunuldu. Perikardiyal efuzyonun sitolojik incelemesinde malign hucreler gozlenir iken, biyopsi sonucunda noduler sklerozan tip Hodgkin lenfoma tanisi dogrulandi. Anah tar soz cuk ler: Hodgkin lenfoma; malign perikardiyal efuzyon; perikardiyosentez. Malignant pericardial effusions (MPE) account for approximately 21% of all patients with advanced malignancies. The standard approach to management of MPE has remained controversial. In this article, we present the case of an 18-year-old female who was admitted to our clinic with pericardial tamponade. A cytological examination of the pericardial effusion revealed malignant cells, and the biopsy confirmed the diagnosis of Hodgkin’s lymphoma of the nodular sclerosing type.
Antimicrobial resistance among Shigella in New Zealand.

AIM We undertook a national survey to provide current information on antimicrobial resistance among Shigella isolated in New Zealand. METHODS Diagnostic laboratories are requested to refer all Shigella isolates to the Institute of Environmental Science and Research (ESR) for epidemiological typing as part of the national surveillance of shigellosis. The antimicrobial susceptibility of 263 non-duplicate Shigella isolates referred to ESR in 2015 and 2016 was tested. RESULTS The 263 Shigella comprised 141 (53.6%) S. sonnei, 113 (43.0%) S. flexneri, 7 (2.7%) S. boydii and 2 (0.8%) S. dysenteriae. Among the 141 S. sonnei, the majority were either biotype g (90) or biotype a (50). Rates of resistance to the two currently recommended first-line antibiotics, co-trimoxazole and fluoroquinolones, were relatively high at 56.7% and 22.8%, respectively. Azithromycin is considered a second-line treatment option, but 11.0% of Shigella were categorised as having a non-wildtype (NWT) azithromycin phenotype (ie, having some mechanism of azithromycin resistance although not necessarily clinically resistant). There were several significant differences in resistance between the two most prevalent S. sonnei biotypes, with resistance being significantly more prevalent among biotype g isolates. Shigella from patients who had not travelled overseas were significantly more likely to be azithromycin NWT than isolates from patients who had recently travelled (20.7 vs 5.6%). Azithromycin NWT was more prevalent among Shigella from males than females (13.9 vs 7.7%). CONCLUSIONS These results suggest there is an immediate need to revise the currently recommended first-line treatment for shigellosis, especially when treatment is given on an empirical basis. Equally concerning is the fact that resistance to the second-line antibiotic for shigellosis, azithromycin, appears to be emerging in New Zealand. As diagnostic laboratories increase their use of culture-independent testing, it is recommended that they should continue to culture specimens from all shigellosis cases so that isolates are available for susceptibility testing and epidemiological typing.
Modified DE/Sin for economic dispatch and environmental dispatch

In this paper, the modified differential evolutionary with sine function is developed. This modified algorithm is applied to economic dispatch and environmental dispatch problem. The problem formulations are formulated as single objective function. The simple 6 units system is used as test system. The constraints of generations are used to control the power limit of generators. The parameters of modified differential evolutionary with sine function and original differential evolutionary are set as the same value. Test results indicate that modified differential evolutionary with sine function can determine the better results than those from original differential evolution in both problems.
Stagodontid marsupials from the Late Cretaceous of Canada and their systematic and functional implications

Previously undescribed specimens of stagodontid marsupials from Late Cretaceous deposits in Alberta, Canada, reveal new information concerning the upper dentition of Eodelphis spp. and the lower dentition of Didelphodon coyi. Addition− ally, an incomplete upper dentition of D. coyi from the Scollard Formation extends the range of this species into the Lancian, co−eval with D. vorax and D. padanicus. Stagodontids are in accord with other North American Late Cretaceous marsupials for which the appropriate parts are known in lacking diastemata between the canines and the molars while pos− sessing well−developed palatal vacuities, implying that these morphologies characterized ancestral marsupials. If so, the diastema between P1 and P2 in the Asian middle Early Cretaceous “metatherian” Sinodelphys szalayi is convergent on that in Cenozoic didelphids, and the absence of palatal vacuities in South American Paleogene and Neogene borhyaenids is derived, representing a paedomorphic truncation of development. Claims that the Asian Late Cretaceous “metatherian” Deltatheridium pretrituberculare had a marsupial−like dental replacement pattern are tautological, deduced from an a pri− ori acceptance of a marsupial model of replacement to the exclusion of other, no less realistic, alternatives. The new speci− mens of Didelphodon coyi demonstrate that upper and lower premolars occluded broadly, implying that the inflated lin− gual lobes characteristic of Didelphodon premolars evolved primarily as a crushing mechanism, not for passive protec− tion of the gums. Recent speculations that stagodontids were aquatic are not based on credible morphologic or taphonomic evidence and are dismissed, as is speculation that the Judithian species of Eodelphis are sexual morphs of a single species. Current knowledge of Didelphodon compels correction of numerous errors concerning its morphology as presented in recent analyses of marsupial relationships.
Effect of Organic Selenium from Se-enriched Alga ( Chlorella spp.) on Selenium Transfer from Sows to Their Progeny

The study was conducted to determine the efficacy of organic Se from Se-enriched alga Chlorella spp. in placental transfer to piglets. In group A (n = 8) the sows were fed during the gestation a diet supplemented with inorganic Se (sodium selenite, 0.3 mg/kg). In group B (n = 8) the diet of the sows was supplemented with organic Se from Se-enriched alga (0.3 mg/kg). The Se concentrations in the whole blood (P < 0.05) and in colostrums (P < 0.05) were higher in the group of sows provided with the organic Se form. No differences in GSH-Px activities were found between the two groups. The concentrations of Se in piglet tissues were also higher when the organic form was provided. It is concluded that the use of the organic Se from Se-enriched alga Chlorella spp. in sows resulted in greater transfer of Se to their progeny. Glutathione peroxidase, piglet, inorganic selenium, colostrum