Miracle-dz/UniFAR-FTUs huggingface dataset:
Is Strongyloides seropositivity associated with diabetes mellitus? A retrospective case-control study in an East London NHS Trust

BACKGROUND The association between diabetes and Strongyloides stercoralis remains controversial. We conducted a case-control study examining the association between diabetes and Strongyloides seropositivity in a large UK centre. METHODS Between January 2013 and October 2016, cases and controls were identified by positive and negative Strongyloides serology, respectively. Demographic, clinical and microbiological data were retrospectively collected. Multivariate logistic regression analysis was performed. RESULTS Over the study period, 532 samples were serologically tested for Strongyloides. After exclusion of duplicates and cases with missing data, 100 (22.3%; 95% CI 18.5-26.4%) out of 449 tested positive. Of seropositive cases, the mean age was 57 years (SD 16), 71 (71%) were male, 94 (94%) were migrants and 92 (92%) had eosinophilia.Univariate logistic regression analysis demonstrated a significant association between Strongyloides seropositivity and age (OR 1.04, 95% CI 1.02-1.05), male sex (OR 2.22, 95% CI 1.37-3.59), migration (OR 5.36, 95% CI 2.27-12.67), eosinophilia (OR 4.36, 95% CI 2.04-9.33) and diabetes (OR 3.52, 95% CI 2.19-5.66). In multivariate analysis, there remained a significant association between diabetes and Strongyloides seropositivity (OR 1.81, 95% CI 1.04-3.16). CONCLUSIONS We demonstrated a high rate of Strongyloides seropositivity in our East London cohort and a significant association with diabetes.
Early Pars Plana Vitrectomy for Treatment of Acute Infective Endophthalmitis

Purpose: To evaluate the efficacy and safety of early pars plana vitrectomy (PPV) for the treatment of acute infective endophthalmitis, and identify prognostic factors for better visual outcome. Design: Retrospective cohort study. Methods: Consecutive patients who underwent early PPV within 72 hours of presentation for the treatment of acute infective bacterial endophthalmitis and presented to a large tertiary referral center in New South Wales, Australia, between January 2009 and December 2013 were included. Changes in best‐corrected visual acuity (VA) from baseline to 1 year were examined. Results: A total of 64 patients were included. The inciting events were cataract surgery (53%), intravitreal injection (36%), trabeculectomy (3%), and endogenous (3%). The mean VA improved from 3.1 logMAR (hand motion) at baseline to 1.02 (approximately 20/200) at 1 year, with 42% achieving final VA equal to or better than 0.477 logMAR (20/60) following early PPV. Positive prognostic factors were negative microbial cultures (P < 0.01) and etiology of post‐cataract surgery (P < 0.01). In multivariable analyses adjusting for age and prognostic factors, patients with baseline VA of light perception and hand motion achieved greater visual gains than those with counting fingers, with gains of logMAR of −2.68, −2.09, and −0.85, respectively (P < 0.0001). Conclusion: Most patients who undergo early PPV experience substantial VA improvement. Negative microbial cultures and endophthalmitis after cataract surgery were associated with better final visual outcome. Patients with presenting VA of light perception or hand motion achieved higher visual gains than those with counting fingers, suggesting the possibility that early PPV may be beneficial in both groups.
Ambient air pollution and the hospital outpatient visits for eczema and dermatitis in Beijing: a time-stratified case-crossover analysis.

BACKGROUND Eczema and dermatitis are a group of common skin conditions with multiple risk factors. Evidence of the effects of air pollutants on eczema and dermatitis remains limited. This study aimed to investigate the effects of short-term exposure to air pollution on eczema and dermatitis in Beijing. METHODS A time-stratified case-crossover design was used to assess the associations between short-term changes in air pollution and the hospital outpatient visits for eczema and dermatitis in Beijing. RESULTS A total of 157 595 outpatient visits for eczema and dermatitis were recorded from April 1, 2012 to April 30, 2014. All pollutants showed significant positive associations with the number of outpatient visits for eczema and dermatitis on lag 0 (the current day). Per IQR increase in PM2.5, PM10, NO2 and SO2 was associated with 3.81% (95% CI: 2.92-4.7%), 3.18% (95% CI: 2.39-3.97%), 5.43% (95% CI: 4.43-6.43%) and 5.57% (95% CI: 4.55-6.58%) increases in outpatient visits for eczema and dermatitis on lag 0. Associations of air pollutants with eczema and dermatitis outpatient visits varied with the seasons and were stronger among older people and females. Also, an association of consecutive days' high concentration pollution with increased outpatient visits was observed. CONCLUSIONS Exposure to air pollution increases the exacerbation of eczema and dermatitis and stronger positive associations between air pollutants and outpatient visits for eczema and dermatitis were found among the aged, females and when high concentration air pollution occurs continuously.
Oncogenic comparison of human papillomavirus type 58 E7 variants

Human papillomavirus 58 (HPV58) ranks the second or third in East Asian cervical cancers. Current studies on HPV58 are scarce and focus on the prototype. Previously, we identified the three most common circulating HPV58 E7 strains contained amino acid alterations: G41R/G63D (51%), T20I/G63S (22%) and T74A/D76E (14%) respectively. Among them, the T20I/G63S variant (V1) had a stronger epidemiological association with cervical cancer. We therefore suggested that V1 possessed stronger oncogenicity than the other two variants. Here, we performed phenotypic assays to characterize and compare their oncogenicities with HPV58 E7 prototype. Our results showed that overexpression of V1 conferred a higher colony‐forming ability to primary murine epithelial cells than prototype (P < 0.05) and other variants, implicating its higher immortalising potential. Further experiments showed that both V1 and prototype enhanced the anchorage‐independent growth of NIH/3T3 cells (P < 0.001), implicating their stronger transforming power than the two other variants. Moreover, they possessed an increased ability to degrade pRb (P < 0.001), which is a major effector pathway of E7‐driven oncogenesis. Our work represents the first study to compare the oncogenicities of HPV58 E7 prototype and variants. These findings deepened our understanding of HPV58 and might inform clinical screening and follow‐up strategy.
Variation in the possessive allomorphy of Hungarian

Hungarian possessive allomorphy, and, in particular, the third person singular possessive ( poss 3 sg ), is a complex pattern influenced by phonological, morphological, and lexical factors. The most intricate one is phonological conditioning: while possessive suffixation shows categorical behavior in certain environments, it is subject to extensive variation in others. This paper looks at possessive variation in the 3 sg and tries to account for its patterning, especially with stems ending in a consonant that is neither palatal nor sibilant, where variation is the most complex. We argue that the observed variation can be understood if one assumes that this particular function is formally underdetermined, and therefore is affected by a variety of influences, including the behavior of similar items in the language user’s lexicon.
Medical Cannabis Users’ Comparisons between Medical Cannabis and Mainstream Medicine

ABSTRACT An evidence-based approach is needed to shape policies and practices regarding medical cannabis, thereby reducing harm and maximizing benefits to individuals and society. This project assesses attitudes towards and utilization of medical cannabis and the mainstream healthcare system among medical cannabis users. The research team administered brief hard copy surveys to 450 adults attending an annual public event advocating for cannabis law reform. Among usable responses (N = 392), the majority (78%) reported using cannabis to help treat a medical or health condition. Medical cannabis users reported a greater degree of use of medical cannabis and a greater degree of trust in medical cannabis compared to mainstream healthcare. In comparison to pharmaceutical drugs, medical cannabis users rated cannabis better on effectiveness, side effects, safety, addictiveness, availability, and cost. Due to the medical use of cannabis, 42% stopped taking a pharmaceutical drug and 38% used less of a pharmaceutical drug. A substantial proportion (30%) reported that their mainstream healthcare provider did not know that they used medical cannabis. Other issues identified included lack of access to mainstream healthcare, self-initiated treatment of health issues, little knowledge of psychoactive content, and heavy cannabis use.
Drepa-Opia: A Pilot Study to Determine the Predictive Factors of Morphine Use and Consumption in Hospitalized Adult Patients with Sickle Cell Disease

Abstract The aim of this study was to evaluate the clinical, biological and genetic factors that could be associated with the use and dose of morphine during hospitalization for vaso-occlussive crisis (VOC) in adults with sickle cell disease. Ninety-nine hospitalizations for acute VOC (58 sickle cell disease patients aged 18 to 60 years, one to six hospitalizations each) were recorded; we investigated the associations between qualitative and quantitative opioid requirements and several biological, clinical, epidemiological and genetic parameters. Visual analog pain scale (VAS) was the only independent predictor of the qualitative need for morphine (mean value of 8.5 vs. 6.1 for the 77 hospitalizations that required morphine). A higher total administered morphine dose, which relates mainly to the overall crisis severity, was associated with a lower hemoglobin (Hb) level at entry. The mean daily morphine dose, which is more influenced by the individual sensitivity to morphine, was not influenced by the studied genetic parameters [sickle cell disease type, α-thalassemia (α-thal) status, UGT2B7 and ABCB1 genotypes] but a very slight negative association was found with the total bilirubin (BIL) level at entry. Our study demonstrated that physicians are often reluctant to prescribe morphine in sickle cell disease as a VAS of 6 corresponds to the usual threshold of administration in other instances. Total Hb at entry was also associated for the first time with higher total morphine consumption and could be used in a predictive VOC severity score. These results have to be confirmed and completed on larger cohorts.
SDVL: Efficient and Accurate Semi-Direct Visual Localization

Visual Simultaneous Localization and Mapping (SLAM) approaches have achieved a major breakthrough in recent years. This paper presents a new monocular visual odometry algorithm able to localize in 3D a robot or a camera inside an unknown environment in real time, even on slow processors such as those used in unmanned aerial vehicles (UAVs) or cell phones. The so-called semi-direct visual localization (SDVL) approach is focused on localization accuracy and uses semi-direct methods to increase feature-matching efficiency. It uses inverse-depth 3D point parameterization. The tracking thread includes a motion model, direct image alignment, and optimized feature matching. Additionally, an outlier rejection mechanism (ORM) has been implemented to rule out misplaced features, improving accuracy especially in partially dynamic environments. A relocalization module is also included but keeping the real-time operation. The mapping thread performs an automatic map initialization with homography, a sampled integration of new points and a selective map optimization. The proposed algorithm was experimentally tested with international datasets and compared to state-of-the-art algorithms.
Memory T Cell Dynamics in the Lung during Influenza Virus Infection

Influenza A virus is highly contagious, infecting 5–15% of the global population every year. It causes significant morbidity and mortality, particularly among immunocompromised and at-risk individuals. Influenza virus is constantly evolving, undergoing continuous, rapid, and unpredictable mutation, giving rise to novel viruses that can escape the humoral immunity generated by current influenza virus vaccines. Growing evidence indicates that influenza-specific T cells resident along the respiratory tract are highly effective at providing potent and rapid protection against this inhaled pathogen. As these T cells recognize fragments of the virus that are highly conserved and less prone to mutation, they have the potential to provide cross-strain protection against a wide breadth of influenza viruses, including newly emerging strains. In this review, we will discuss how influenza-specific memory T cells in the lung are established and maintained and how we can harness this knowledge to design broadly protective influenza A virus vaccines.
Nail Involvements as an Indicator of Skin Lesion Severity in Psoriatic Patients.

Psoriasis is a recurrent chronic inflammatory skin disease with various mild to severe clinical manifestations. The relationship between severity of the skin lesions and nail involvement has always been underestimated. Aim of the study was to evaluate the severity of skin involvement in psoriatic patients with and without nail manifestations. In this analytic cross-sectional study, patients with psoriasis referred to Razi University Hospital of Rasht from November 2015 to March 2016 were enrolled. Demographical features (i.e. age, gender) were obtained. Psoriasis severity and nail involvement criteria were assessed by Psoriasis Area and Severity Index (PASI) and Nail Psoriasis Severity Index (NAPSI), respectively. All the gathered data were analyzed by SPSS software. In this study, 71 psoriatic patients with a mean age of 39.23±17.9 years (mean ± Standard Deviation; range: 4 to 77 years old) were studied. 22 patients (31%) had nail involvements. PASI scores were 11.7±5.7 and 5.7±4.5 in the two groups with and without nail involvements, respectively (P<0.001). There were no significant differences between age, age of onset, and duration of the disease between the two groups (P>0.05). The correlation coefficient between PASI and NAPSI was 0.367, which was statistically significant (P<0.001). Based on the findings of our study, nail involvement is an important criterion in determining the severity of skin manifestations in psoriatic patients. Additionally, a high percentage of such patients probably manifest both skin and nail manifestations. Therefore it is highly recommended to consider nail involvement when evaluating psoriasis.
Investigating the Hypothesis of Stress System Dysregulation as a Risk Factor for Central Serous Chorioretinopathy: A Literature Mini-Review

ABSTRACT Background: This mini-review addressed the question “what do we know about the association between the dysregulation of stress systems (HPA axis and SAM) and the onset and prognosis of CSC in adult populations? ” Methods: The literature mini-review was conducted through electronic searches using the PubMed, Web of Science, and Scopus databases. All published human and animal studies with both observational and experimental designs from 1966 to October 2018 were included. Results: Our search identified 229 reports, of which 32 articles were ultimately identified to be reviewed in this paper. Among these key articles, twenty-three were related to exogenous and/or endogenous high glucocorticoids as risk factors for CSC, seven were related to Type-A behavior and chronic psychological distress as risk factors for idiopathic CSC, and two were related to stress-induced animal models of CSC. Nineteen out of twenty-three studies in the first group reported a consistent association between high circulating corticosteroids and the onset and prognosis of CSC. Six out of seven studies in the second group reported a consistent association between stress-induced allostatic (over)load and the appearance of more- or less-severe CSC disorders, assuming that elevated circulating steroids may constitute a kind of risk factor for the eye through dysregulation of the HPA axis. All the selected studies reported HPA axis dysregulation as a possible common factor to explain the association between high circulating corticosteroids and CSC. In contrast, the involvement of the SAM system is only indirectly taken into consideration through the PA and HR measures and/or plasma and 24-h urinary catecholamine levels. Therefore, information regarding the involvement of SAM system dysregulation in the onset and prognosis of CSC is lacking. This observation is particularly relevant in view of the fact that animal models of CSC in monkeys are primarily induced by adrenergic hypertonia and that the course of experimental CSC is not further exacerbated by the administration of corticosteroids.
The Use of Context in Large Vocabulary Speech Recognition

In recent years, considerable progress has been made in the eld of continuous speech recognition where the predominant technology is based on hidden Markov models (HMMs). HMMs represent sequences of time varying speech spectra using probabilistic functions of an underlying Markov chain. However, because the probability distribution represented by a HMM is very simple, its discriminative ability is limited. As a consequence, a careful choice of the units represented by each model is required in order to accurately model the variation inherent in natural speech. In practice, much of the variation is due to consistent contextual eeects and can be accounted for by using context dependent models. In large vocabulary recognition the use of context dependent models introduces two major problems. Firstly, some method must be devised to determine the set of contexts which require distinct models. Furthermore, this must be done in a way which takes account of the sparsity and unevenness of the training data. Secondly, a strategy must be devised which allows eecient decoding using models incorporating context dependencies both within words and across word boundaries. This thesis addresses both of these key problems. Firstly, a method of constructing robust and accurate recognisers using decision tree based clustering techniques is described. The strength of this approach lies in its ability to accurately model contexts not appearing in the training data. Linguistic knowledge is used, in conjunction with the data, to decide which contexts are similar and can share parameters. A key feature of this approach is that it allows the construction of models which are dependent upon contextual eeects occurring across word boundaries. The use of cross word context dependent models presents problems for conventional de-coders. The second part of the thesis therefore presents a new decoder design which is capable of using these models eeciently. The decoder is suitable for use with very large vocabularies and long span language models. It is also capable of generating a lattice of word hypotheses with little computational overhead. These lattices can be used to constrain further decoding, allowing eecient use of complex acoustic and language models. The eeectiveness of these techniques has been assessed on a variety of large vocabulary continuous speech recognition tasks and results are presented which analyse performance in terms of computational complexity and recognition accuracy. The experiments demonstrate state of the art performance and a recogniser using these techniques was used in the 1994 US …
A systematic review with meta‐analysis on functional changes associated with neck pain in adolescents

BACKGROUND Neck pain (NP) is highly prevalent in young people, but there has been no systematic review synthetizing the functional changes associated with this in adolescents. The aim of the present study was to identify and assess critically the evidence on the functional changes associated with NP in adolescents, specifically for: (a) posture; (b) postural control; (c) range of motion; (d) proprioception; (e) muscle function; and (f) sensory threshold. METHODS We searched PubMed, ScienceDirect, Web of Science, PEdro, Scielo, Scopus and Academic Search Premier databases for relevant studies. Two reviewers screened studies for inclusion and assessed the quality of the included studies. One reviewer extracted relevant data from the included studies. A meta-analysis was performed for studies that measured forward head posture (FHP). RESULTS Ten studies were included and a total of 15 comparisons for different variables were made. When compared with adolescents without NP, those with NP showed no differences in cervicothoracic posture or FHP. However, statistically significant differences were found for range of motion: weighted mean difference (WMD) from -14.0° (-21.1° to -1.1°) to 9.4° (2.8° to 16.0°); flexor muscle endurance: WMD -11.4 (-21.8 to -0.9) s; extensor muscle endurance: WMD -42.0 (-77.8 to -6.3) s; joint repositioning error for right and left rotation: WMD 1.9° (0.8° to 2.9°) and 2.4° (1.3° to 3.5°), respectively; and pressure pain threshold: WMD from -15.6 (-18.5 to -12.8) to -9.3 (-11.3 to 7.2) N/ cm². CONCLUSION There is very limited to limited evidence that there is no difference in posture between adolescents with and without NP, and that there is a difference for range of motion, muscle function, proprioception and pressure pain threshold.
The Relationship between Perceived Stress and Marital Satisfaction in Couples with Infertility: Actor-Partner Interdependence Model

Background Infertility, one of life’s great stressors, may adversely affect marital satisfaction. No studies have in- vestigated the relationship between perceived stress and marital satisfaction at the dyadic level. The current study assessed the actor and partner effects of perceived stress on marital satisfaction in husband-wife dyads using an in- novative dyadic analysis approach, the Actor-Partner Interdependence Model (APIM). Materials and Methods In this cross-sectional study, we recruited a total of 141 infertile couples. Marital satisfac- tion and stress were assessed using the ENRICH Marital Satisfaction Scale (EMS Scale) and Perceived Stress Scale-4 Item (PSS-4), respectively. Dyadic data have been analysed by the APIM approach, with distinguishable dyads. In this approach, actor effect is the impact of a person᾽s perceived stress on his/her own marital satisfaction. Partner effect is the impact of a person's perceived stress on the partner᾽s marital satisfaction. Results Both men and women’s perceived stress exhibited an actor effect on their marital satisfaction (β=-0.312, P<0.001, β=-0.405, P<0.001, respectively). Women’s perceived stress had a negative relationship to the marital satis- faction of their partner (β=-0.174, P=0.040). Although the partner effect of men’s perceived stress on woman’s marital satisfaction was not significant (β=-0.138, P=0.096), women whose husbands had higher levels of stress were more likely to have poorer marital satisfaction. Both actor and partner effects of perceived stress on marital satisfaction were similar among men and their wives. Conclusion The findings of this study have highlighted that marital satisfaction in patients with infertility was in- fluenced by not only their own perceived stress, but also their spouses’ perceived stresses. Therefore, psychological interventions that target a reduction in perceived stress and enhancement of marital satisfaction in the context of infer- tility should treat the couple as a unit.