Miracle-dz/UniFAR-FTUs huggingface dataset:
Weight stigma, coping strategies, and mental health among children with overweight

Introduction: Obesity/overweight (hereafter, overweight indicates both obesity and overweight) is an important health issue that is gaining growing interest worldwide. One health issue for children with overweight is stigma. The aims of this study were (1) to detect the impact of stigma on mental health and (2) to probe the effects of positive and negative coping on the mental health of children with overweight. Methods: The author conducted a secondary data analysis using two waves of data from the Taiwan Education Panel Survey (TEPS): the first wave in 2001 and the second wave in 2003. A group of junior high school students (in the 7th grade in the first wave; n = 2612; nmale = 1171) was used for data analysis. Items in the TEPS were categorized into the following five variables: mental health (nine items), stigma from peers (three items in relationship with peers and four items in bullying experience), stigma from parents (four items), positive coping strategies (six items in increasing social activities and two items in increasing self-study activities), and negative coping strategies (five items). Results: The overweight group experienced more peer stigma than the normal-weight group. Bullying experience, stigma from parents, and self-study activities were significantly correlated to mental health in both groups. The overweight group demonstrated stronger negative relationships between bullying events, negative strategies, and mental health than the normal-weight group; a weaker negative relationship was shown between stigma from parents and mental health. Conclusion: Stigma and negative strategies could endanger mental health among children with overweight.
Cathepsins in oral diseases

Cathepsins are a class of globular lysosomal proteases known to be responsible for protein degradation. In addition to proteolysis they have many biological roles such as apoptosis wound healing angiogenesis, proenzymatic activation, bone remodelling and resorption. Cathepsins role has been implicated in the pathogenesis of systemic diseases such as cancer, bronchial asthma, atherosclerosis, neurological disorders, rheumatoid arthritis and osteoarthritis. This review highlights the role of cathepsins in various oral diseases like periodontitis, odontogenic cysts, ameloblastomas, salivary gland tumours and oral malignant melanoma.
Differences in Personal, Familial, Social, and School Factors Between Underachieving and Non-underachieving Gifted Secondary Students

Using various identification methods, differences between underachieving and non-underachieving gifted students in personal, familial, social, and school variables were analyzed in a sample of 164 gifted students with IQs of 120 or higher; the sample was drawn from a larger sample of 1,400 compulsory secondary education students. Three procedures for identifying underachieving students were used: the standardized difference method, the regression method, and the Rasch method. The different profiles of underachieving and non-underachieving students in the personal, familial, social, and school variables were compared using MANOVA and ANOVA tests. Results revealed that underachieving gifted students scored significantly lower in learning strategies, goal orientations, self-concept, attitudes toward teachers, and perceived parent involvement in school variables. These results have clear educational implications as a result of identifying differences in non-cognitive factors.
Alternative Photosynthetic Electron Transfers and Bleaching Phenotypes Upon Acute Heat Stress in Symbiodinium and Breviolum spp. (Symbiodiniaceae) in Culture

The breakdown of the symbiosis between cnidarians and Symbiodiniaceae often occurs upon periods of elevated sea surface temperature and gives rise to bleaching events that affect coral reefs worldwide. In the prevailing model explaining the cellular mechanisms of bleaching, an impairment of photosynthesis would be responsible for light-dependent generation of toxic reactive oxygen species and ultimately for death of symbionts and/or host cells. In some Symbiodiniaceae species, alternative photosynthetic electron flows (AEF) have been documented to occur upon a shift to high temperature, possibly contributing to photoprotection and to the balance of energetic ratio between photoproduced ATP and NADPH. By using a combination of in vivo spectrofluorimetric and oximetric techniques, we studied the capacity for electron rerouting towards oxygen and cyclic electron flow around photosystem I in nine Symbiodiniaceae species belonging to Symbiodinium and Breviolum genera upon a shift from 25°C to 33°C. CEF capacity was determined as the kinetic of PSI primary donor P700 re-reduction in the presence of DCMU, a PSII inhibitor. An active oxygen uptake in light was estimated by comparing net oxygen evolution and relatove electron transport rate of PSII at different light intensities. Among strains that showed elevated capacity for both AEF, some were thermotolerant while others were thermosensitive. Conversely, in some thermotolerant strains, capacities for these AEF were low upon heat stress. Our results thus indicate that a high CEF capacity and/or a high ability to reroute electrons towards O2 are not sufficient to confer thermal resistance of isolated Symbiodiniaceae.
Neoadjuvant Multikinase Inhibitor in Patients With Locally Advanced Unresectable Thyroid Carcinoma

Background: Papillary thyroid carcinoma (PTC) is the most common and less aggressive thyroid cancer, but some patients may display locally advanced disease. Therapeutic options are limited in these cases, particularly for those patients with unresectable tumors. Neoadjuvant therapy is not part of the recommended work up. Methods: Report a case of an unresectable grossly locally invasive PTC successfully managed with neoadjuvant therapy and provide a systematic review (SR) using the terms “Neoadjuvant therapy” AND “Thyroid carcinoma. ” Results: A 32-year-old man with a 7.8 cm (in the largest dimension) PTC was referred to total thyroidectomy, but tumor resection was not feasible due to extensive local invasion (trachea, esophagus, and adjacent structures). Sorafenib, a multikinase inhibitor (MKI), was initiated; a 70% tumor reduction was observed after 6 months, allowing new surgical intervention and complete resection. Radioactive iodine (RAI) was administered as adjuvant therapy, and whole body scan (WBS) shows uptake on thyroid bed. One-year post-surgery the patient is asymptomatic with a status of disease defined as an incomplete biochemical response. The SR retrieved 123 studies on neoadjuvant therapy use in thyroid carcinoma; of them, 6 were extracted: 4 case reports and 2 observational studies. MKIs were used as neoadjuvant therapy in three clinical cases with 70–84% of tumor reduction allowing surgery. Conclusion: Our findings, along with other reports, suggest that MKIs is an effective neoadjuvant therapy and should be considered as a therapeutic strategy for unresectable grossly locally invasive thyroid carcinomas.
In Adult Rats With Polycystic Ovarian Syndrome, Unilateral or Bilateral Vagotomy Modifies the Noradrenergic Concentration in the Ovaries and the Celiac Superior Mesenteric Ganglia in Different Ways

In rats with polycystic ovarian syndrome (PCOS) induced by estradiol valerate (EV) injection, sectioning of the vagus nerve in the juvenile stage restores ovulatory function, suggesting that the vagus nerve stimulates the onset and development of PCOS. We analyzed whether in adult rats, the role played by the vagus nerve in PCOS development is associated with the nerve’s regulation of noradrenergic activity in the celiac superior mesenteric ganglion (CSMG). Ten-day-old rats were injected with corn oil [vehicle (Vh)] or EV (2 mg). At 76 days of age, rats injected with Vh or EV were subjected to sham surgery or the sectioning of one or both vagus nerves (vagotomy). The animals were sacrificed at 80–82 days of age at vaginal estrus smear. Compared to Vh-treated animals, EV-induced PCOS rats showed a lack of ovulation, the presence of follicular cysts, and a high concentration of testosterone, without changes in noradrenaline concentrations in the CSMG or ovaries. In PCOS rats, sham surgery lowered serum testosterone and noradrenaline concentrations in the CSMG but did not restore ovulation. In animals with PCOS, vagotomy lowered testosterone concentrations to a larger degree than in sham-surgery animals. The ovaries of rats with PCOS and vagotomy showed fresh corpora lutea, indicating ovulation. In EV-treated rats with unilateral vagotomy, the concentration of noradrenaline in the CSMG was similar to that in rats with PCOS and sham surgery, which did not ovulate, while in the ovaries of PCOS rats with left or bilateral vagotomy, the noradrenaline concentration was lower than that in sham-surgery-treated animals. Our results suggest that the vagus nerve regulates PCOS development through a different mechanism than the increase in the noradrenergic activity in the CSMG; however, in ovaries, the restoration of ovulation is associated with a decrease in ovarian noradrenaline.
Red Light, Purple Light! Results of an Intervention to Promote School Readiness for Children From Low-Income Backgrounds

Considerable research has examined interventions that facilitate school readiness skills in young children. One intervention, Red Light, Purple Light Circle Time Games (RLPL; Tominey and McClelland, 2011; Schmitt et al., 2015), includes music and movement games that aim to foster self-regulation skills. The present study (N = 157) focused on children from families with low-income and compared the RLPL intervention (SR) to a revised version of RLPL that included literacy and math content (SR+) and a Business-As-Usual (BAU) control group. In both versions of the intervention, teachers were trained to administer the self-regulation intervention in preschool classrooms with coaching support. Although not statistically significant, children receiving either version of the intervention gained more in self-regulation on the Head-Toes-Knees-Shoulders (HTKS) over the preschool year compared to the BAU group (β = 0.09, p = 0.082, Cohen’s d = 0.31). Effect sizes were similar to previous studies (Schmitt et al., 2015; Duncan et al., 2018) and translated to a 21% difference in self-regulation over and above the BAU group at post-test. Furthermore, children participating in either version of the intervention gained significantly more in math across the school year compared to children in the BAU group (β = 0.14; p = 0.003, Cohen’s d = 0.38), which translated to a 24% difference in math over and above the BAU group at post-test. Results were somewhat stronger for the SR+ version, although effect sizes across intervention conditions were comparable. There were no statistically significant differences across groups for literacy skills. Results extend previous research and suggest that the RLPL intervention, which includes an explicit focus on self-regulation through music and movement games, may improve children’s self-regulation and math scores over the preschool year.
Effective Deep Brain Stimulation for Obsessive-Compulsive Disorder Requires Clinical Expertise

Background Deep brain stimulation (DBS) is an innovative treatment for severe obsessive-compulsive disorder (OCD). Electrodes implanted in specific brain areas allow clinicians to directly modulate neural activity. DBS affects symptomatology in a completely different way than established forms of treatment for OCD, such as psychotherapy or medication. Objective To understand the process of improvement with DBS in patients with severe OCD. Methods By means of open-ended interviews and participant observation we explore how expert clinicians involved in the post-operative process of DBS optimization evaluate DBS effects. Results Evaluating DBS effect is an interactive and context-sensitive process that gradually unfolds over time and requires integration of different sources of knowledge. Clinicians direct DBS optimization toward a critical point where they sense that patients are being moved with regard to behavior, emotion, and active engagement, opening up possibilities for additional cognitive behavioral therapy (CBT). Discussion Based on the theoretical framework of radical embodied cognitive science (RECS), we assume that clinical expertise manifests itself in the pattern of interaction between patient and clinician. To the expert clinician, this pattern reflects the patient’s openness to possibilities for action (“affordances”) offered by their environment. OCD patients’ improvement with DBS can be understood as a change in openness to their environment. The threshold for patients to engage in activities is decreased and a broader range of daily life and therapeutic activities becomes attractive. Movement is improvement.
Physical Activity, Sedentary Behavior, and Barriers to Exercise in People Living With Dystonia

Background: Dystonia is a neurological movement disorder that presents as sustained or intermittent involuntary muscle contractions causing abnormal postures and movements. Knowledge of dystonia is mostly at the impairment level with minimal understanding of activity and participation limitations. Physical activity (PA) is an important aspect of neurological disease management, with wide-ranging benefits for overall health and quality of life. No studies have quantified PA and sedentary behavior (SB), nor explored barriers to being physically active in people with dystonia. Methods: Participants diagnosed with any form of dystonia completed a mixed-methods anonymous online survey on activity behaviors. The International Physical Activity Questionnaire (IPAQ) and Adult Sedentary Behavior Questionnaire (SBQ) assessed self-reported PA and SB. Barriers to exercise engagement were investigated according to the five-factor social-ecological framework and dystonia-specific questions regarding the impact of exercise on symptoms were included. Results: Two-hundred and sixty-three participants consented to the study (mean (SD) age = 55 (13) years, 76% Female). A large proportion of respondents (40%) reported living with cervical dystonia (CD). Overall, the median (IQR) time spent in walking, moderate, and vigorous activity was 60 (0–120), 120 (15–300), and 0 (0–13) min/day, respectively. SB time during weekdays was 285.0 (157.5–465.0) min/day and 345.0 (195.0–502.5) min/day on weekends. Fifty-five percent of participants were dissatisfied with their current level of PA and 75% reported dystonia had decreased their level of PA. Fifty-seven percent found their symptoms were worsened during exercise though the after-effects on symptoms varied. Fatigue, motor symptoms, pain, and poor balance were commonly cited limiting factors. Qualitative and quantitative data indicated difficulties with more vigorous intensity activity. The common barriers to engagement were personal and governmental factors, such as physical impairments, lack of funding and lack of trained exercise professionals. Conclusion: While more than half of respondents indicated they were not satisfied with their current level of PA, and exercise primarily worsened their dystonia symptoms, most participants were meeting the minimum guidelines. Future studies should incorporate robust objective methods of PA and SB measurement and explore the causal mechanisms underpinning exercise-induced aggravation of dystonic symptoms to further enhance life participation of people living with dystonia.
Parents or Peers? Predictors of Prosocial Behavior and Aggression: A Longitudinal Study

The aim of this longitudinal study was to determine the associations among peer attachment, warmth from the mother and father, strict control by the mother and father, prosocial behavior, and physical and verbal aggression in adolescence. Few longitudinal studies have examined how peer attachment and parenting styles of the mother and father relate to prosocial behavior and aggression. Participants were 192 boys and 255 girls (M = 14.70 years; SD = 0.68) in wave 1. In the study participated 11 schools. For three successive years, participants reported on their fathers’ and mothers’ warmth and strict control, peer attachment, prosocial behavior, and aggression. Structural equations modeling was employed to explore two longitudinal models. Results show the influence of the mother and father on prosocial and aggression during adolescence. In addition, strong peer attachment predicted prosocial behavior in subsequent years. Therefore, the findings indicate that despite the increasingly important role of friends during the transition from childhood to adolescence, parenting styles play a key role in the personal and social development of their children. Programs aimed at preventing aggression should be designed considering the importance of stimulating and strengthening prosocial behavior, peer attachment and a family environment of affect, support and communication.
Bread Wheat With High Salinity and Sodicity Tolerance

Soil salinity and sodicity are major constraints to global cereal production, but breeding for tolerance has been slow. Narrow gene pools, over-emphasis on the sodium (Na+) exclusion mechanism, little attention to osmotic stress/tissue tolerance mechanism(s) in which accumulation of inorganic ions such as Na+ is implicated, and lack of a suitable screening method have impaired progress. The aims of this study were to discover novel genes for Na+ accumulation using genome-wide association studies, compare growth responses to salinity and sodicity in low-Na+ bread Westonia with Nax1 and Nax2 genes and high-Na+ bread wheat Baart-46, and evaluate growth responses to salinity and sodicity in bread wheats with varying leaf Na+ concentrations. The novel high-Na+ bread wheat germplasm, MW#293, had higher grain yield under salinity and sodicity, in absolute and relative terms, than the other bread wheat entries tested. Genes associated with high Na+ accumulation in bread wheat were identified, which may be involved in tissue tolerance/osmotic adjustment. As most modern bread wheats are efficient at excluding Na+, further reduction in plant Na+ is unlikely to provide agronomic benefit. The salinity and sodicity tolerant germplasm MW#293 provides an opportunity for the development of future salinity/sodicity tolerant bread wheat.
The Current Situation of Esophageal Cancer Staging and Perioperative Strategies Determination in Central and Southern China: A Cross Sectional Survey

Purpose: We aim to investigate the current esophageal cancer staging according to the 7th edition TNM classification for esophageal carcinoma proposed by American Joint Committee on Cancer (AJCC) among oncology-related physicians in China. Methods: A specifically-designed 14-item questionnaire was distributed to 366 doctors who were working with esophageal cancer patients. We collected and analyzed the feedbacks and explored the possible associations within different departments, including thoracic surgery, the internal medicine of gastroenterology, oncology, and/ radiotherapy in eight different hospitals from central and southern China. Results: Among all the responses, 31.42% of them were from thoracic surgery department, 40.44% were from oncology and/or radiation therapy and 28.14% were from the internal medicine of gastroenterology, respectively. Surprisingly, in total 66.12% of all the physicians were unaware that the 7th edition of esophageal carcinoma TNM classification was released in 2009; only 21.86 and 16.67% of physicians recognized cervical nodes and celiac nodes as regional lymph nodes. Furthermore, 67.21% physicians didn't know that tumor location, histologic grade, and histopathology were accepted as new prognostic factors in the latest TNM system; and 51.37% physicians could not determine the correct TNM classification of esophagogastric junction cancers. Intriguingly, over 50% of them could still design appropriate perioperative strategies. Conclusions: The 7th edition of the TNM classification for esophageal carcinoma is poorly recognized and understood in central and southern China, which might contribute to the relatively low rates of appropriate perioperative procedures applied for esophageal cancer patients.
Organ Preservation and Late Functional Outcome in Oropharyngeal Carcinoma: Rationale of EORTC 1420, the “Best of” Trial

Dysphagia represents one of the most serious adverse events after curative-intent treatments with a tremendous impact on quality of life in patients with head and neck cancers. Novel surgical and radiation therapy techniques have been developed to better preserve swallowing function, while not negatively influencing local control and/or overall survival. This review focuses on the current literature of swallowing outcomes after curative treatment strategies. Available results from recent studies relevant to this topic are presented, demonstrating the potential role of new treatment modalities for early- and intermediate-stage oropharyngeal cancers. Based on this, we present the rationale and design of the currently active EORTC 1420 “Best of” trial, and highlight the potential of this study to help prioritizing either surgery- or radiation-based treatment modalities for the treatment of oropharyngeal cancer in the future.
Processing Sentences With Multiple Negations: Grammatical Structures That Are Perceived as Unacceptable

This investigation draws from research on negative polarity item (NPI) illusions in order to explore a new and interesting instance of misalignment observed for grammatical sentences containing two negative markers. Previous research has shown that unlicensed NPIs can be perceived as acceptable when occurring soon after a structurally inaccessible negation (e.g., ever in *The bills that no senators voted for have ever become law). Here we examine the opposite configuration: grammatical sentences created by substituting the NPI ever with the negative adverb never (e.g., The bills that no senators voted for have never become law). The processing and acceptability of these sentences were studied using three tasks: a speeded acceptability judgment (Experiment 1), a self-paced reading task (Experiment 2), and an offline acceptability rating (Experiment 3). The results are consistent across measures in showing that the integration of the adverb never is disrupted by the linearly preceding but structurally inaccessible negative quantifier no in the relative clause. In our view, this pattern of results is in line with Parker and Phillips’ (2016) proposal that NPI illusions arise when the context containing the inaccessible negation has not been fully encoded by the time the NPI ever is encountered, making the embedded negative quantifier transparently available as a licensor. In a similar vein, the disruption effects observed for grammatical sentences containing two negative elements could arise if the negative quantifier is still being integrated when never is encountered, forcing the parser to deal with two negative elements simultaneously. This interpretation suggests that the same incomplete encodings that could be ameliorating the online perception of unlicensed NPIs could also be responsible for deteriorating the perception of the sentences under investigation here. This would represent an illusion of ungrammaticality. Furthermore, these results provide evidence against the speculation that NPI illusions are the consequence of misrepresenting ever as its near neighbor never, given that continuations with never are judged as unacceptable in spite of their grammaticality. Together, these findings inform the landscape of hypotheses on NPI illusions and offer valuable insights into the complexity of multiple negations and the relation between processing difficulty and acceptability.