Miracle-dz/UniFAR-FTUs huggingface dataset:
Dynamic Energy Management of Renewable Grid Integrated Hybrid Energy Storage System

In this paper, a unified energy management scheme is proposed for renewable grid integrated systems with battery-supercapacitor hybrid storage. The intermittent nature of renewable-energy resources (RES), coupled with the unpredictable changes in the load, demands high-power and high-energy-density storage systems to coexist in today's microgrid environment. The proposed scheme dynamically changes the modes of renewable integrated systems based on the availability of RES power and changes in load as well. The participation of battery-supercapacitor storage to handle sudden/average changes in power surges results in fast dc link voltage regulation, effective energy management, and reduced current stress on battery. In addition, the proposed energy management scheme enables the real power transfer along with ancillary services such as current harmonic mitigation, reactive power support, and power factor improvement at the point of common coupling. The proposed scheme is validated through both simulation and experimental studies.
Shielding effectiveness of flat samples and conductive gaskets: New measuring cell for the frequency range 1–18 GHZ

In the past, different methods have been defined and some standardised for the characterisation of flat samples of shielding materials. Basically, the methods are based on three principles: coaxial cell methods simulating far field conditions, near-field cells (especially magnetic near field) and methods based on a modified Mil Std 285 design. The first two are typically restricted up to the frequency of around 1 GHz, and only the latter one allows measurements above 1 GHz. There is a lack of simple measuring setups in order to characterise the shielding effectiveness of small flat samples in this frequency range of 1- 18 GHz. In this paper, the design and construction of such a measuring is cell is discussed and a first set of measurements is summarised.
Using the same cut-off for sulfur hexafluoride and nitrogen multiple-breath washout may not be appropriate.

Recent evidence suggests that results from multiple-breath washout (MBW) using nitrogen (N 2 ) as washout gas are different to those obtained by using sulfur hexafluoride (SF 6 ). Explanations were mainly related to different MBW equipment and gas properties. We aim to mention a new aspect, namely using the same cut-off in both techniques to determine lung clearance index (usually 2.5% of initial tracer concentration) irrespective of additional contribution of tissue-nitrogen in N 2 -MBW. In a simple model calculation we subtracted 1% tissue-N 2 from the N 2 -MBW in real washout traces from two children, one with cystic fibrosis (CF) and one healthy. This "SF 6 -washout simulation" decreased LCI differently in the children. In the healthy subject 1/40 th (2.5%) was achieved two breaths earlier compared to the original signal and changed LCI from 6.7 to 5.9 (12%), while in CF 1/40 th was achieved 19 breaths earlier leading to a LCI decrease from 13.7 to 10.0 (27%). It would have been required to wash out SF6 until 1/66 th (1.5%) to be comparable to N 2 washout at 1/40th (2.5%), or to stop N2-MBW already at 3.5% of the starting concentration to make both techniques comparable. We show that a basic physiological-mathematical difference between both techniques additionally accounts for different sensitivities and poor agreement between SF 6 - and N 2 -MBW. The best way of adjusting for the contribution of tissue-N 2 needs to be examined in future studies. Thus, despite increasing use in different disease groups, the books on MBW technology are obviously not closed yet.
Evidence of unilateral isolated utricular hypofunction

Abstract Conclusions: The findings demonstrate that an enduring unilateral utricular dysfunction, possibly together with canal hypofunction, can occur after labyrinthine disease or injury. They also suggest that unilateral, isolated utricular dysfunction – or utricle paresis – can occur, representing a novel entity in the differential diagnosis of peripheral vestibular function. The occurrence of subjective visual vertical (SVV) asymmetry in the presence of symmetric vestibular evoked myogenic potentials (VEMPs) also confirms that the information from the utricles, rather than the saccules, dominates SVV estimation. Objectives: To determine the incidence of unilateral utricular hypofunction. Methods: The retrospective clinical study deals with a selection of those vestibular patients who showed pathological responses to utricle testing. Peripheral vestibular function was examined in a group of 110 patients. Utricular function was evaluated by estimation of SVV during unilateral centrifugation. Bithermal caloric testing was performed to assess unilateral semicircular canal function. Saccular function was tested by measurement of VEMPs. Results: A total of 46 patients were found with asymmetric SVV findings (p < 0.001 for healthy versus lesioned ear), but symmetric caloric responses and VEMPs. Statistical testing also verified that their SVV asymmetry factors were significantly higher than those calculated for caloric responses and VEMPs (p < 0.001).
Old and in pain: Enduring and situational effects of cultural aging stereotypes on older people's pain experiences

This study aimed to investigate the interplay between enduring and situational aging stereotype (AS) effects in older adults' self‐reports of clinical and experimentally induced pain. We expected that, as compared with the situational activation of positive AS or a neutral condition, the activation of negative AS would lead to more severe self‐reports of clinical pain (H1, hypothesis 1), higher cold pressor task (CPT) pain threshold (H2) and lower CPT pain tolerance (H3), especially among older adults who more strongly endorsed AS.
Pasireotide (SOM230), a Novel Multireceptor‐Targeted Somatostatin Analogue, Is Well Tolerated When Administered as a Continuous 7‐Day Subcutaneous Infusion in Healthy Male Volunteers

Pasireotide is a novel multireceptor‐targeted somatostatin analogue that has shown efficacy in patients with acromegaly and Cushing's disease when administered by subcutaneous (SC) injection. This study assessed the safety, tolerability, and pharmacokinetics (PK) of a continuous infusion of pasireotide in healthy volunteers. In this single‐center, open‐label, dose escalation study, healthy male volunteers received a 7‐day continuous SC infusion of pasireotide in sequential ascending‐dose cohorts. Single and/or 8‐hour blood samples were taken on days 1 to 10 to assess PK and on days 1, 2, and 7 and a control day to assess glucose metabolism. Adverse events were evaluated throughout. Forty‐four participants were enrolled into 8 cohorts: pasireotide 450, 900, 1350, 1800 (3 cohorts were enrolled at this dose level), 2250, and 2025 μg/d. Doses were well tolerated up to 2025 μg/d. Adverse events were generally mild and gastrointestinal. Pasireotide steady‐state clearance was reduced at high doses, and plasma concentrations increased disproportionately with increasing dose. Blood glucose levels increased after initiation of pasireotide infusion with attenuation by day 7. Insulin and glucagon levels decreased after pasireotide infusion, with insulin levels exhibiting a greater degree of suppression. Pasireotide has the potential to be administered as a long‐acting release formulation, and future studies are warranted.
Biochemical Characterization and Subcellular Localization of the Mouse Retinitis Pigmentosa GTPase Regulator (mRpgr)*

The retinitis pigmentosaGTPase regulator (RPGR) gene encodes a protein homologous to the RCC1 guanine nucleotide exchange factor and is mutated in 20% of patients with X-linked retinitis pigmentosa. We have characterized the full-length and variant cDNAs corresponding to the mouse homolog of the RPGR gene (mRpgr). Comparison with the human cDNA revealed sequence identity primarily in the region of RCC1 homology repeats. As in humans, the mRpgr gene maps within 50 kilobases from the 5′-end of the Otc gene. The mRpgr transcripts are detected as early as E7 during embryonic development and are expressed widely in the adult mice. Variant mRpgr isoforms are generated by alternative splicing and by utilizing two in-frame initiation codons. The products of mRpgr cDNAs migrate aberrantly in SDS-polyacrylamide gels because of a charged domain. In transfected COS cells, the mRpgr protein is isoprenylated and is localized in the Golgi complex. This subcellular distribution is not observed after treatments with brefeldin A or mevastatin and when the conserved isoprenylation sequence (CTIL) at the carboxyl terminus is deleted or mutagenized. These studies suggest a role for the mRpgr protein in Golgi transport and form the basis for investigating the mechanism of photoreceptor degeneration in X-linked retinitis pigmentosa.
Evolutionary epitopes of Hsp90 and p23: implications for their interaction

The amino‐terminal domain (N‐domain) of Hsp90 represents the ATP binding site and is important for interaction with its cochaperone, p23. Whereas some evidence suggests that p23 may bind to this domain in an ATP‐dependent manner and that this process requires the dimerization of two N‐domains, the interaction sites between them and the molecular mechanism of coupling these two events to p23 binding remain unsolved. As a first step toward establishing the interaction mechanism, we used the evolutionary tracing (ET) method [Lichtarge, O. , Bourne, H. R. , and Cohen, F. E. (1996) J. Mol. Biol. 257, 342–358] to identify the putative functional surfaces of Hsp90 and p23, and combined with protein–protein docking techniques, to predict their binding interface. Both evolutionarily privileged surfaces of Hsp90 and p23 identified by ET appear on this putative interface. An analysis of the complex model produced using the ET results combined with available experimental data highlights a putative conformational pathway in the ATP binding domain of Hsp90, where a series of conformational changes transfer the ATP‐induced N‐domain dimerization signal for the binding of p23. In this pathway, the closure of “lid” may result in reorientation of the helix αl and the following loop (residues 10‐27 in yeast Hsp90), which will expose more hydrophobic surface, and thus triggers the dimerization of N‐domain. —Zhu, S. , Tytgat, J. Evolutionary epitopes of Hsp90 and p23: implications for their interaction. FASEB J. 18, 940–947 (2004)
A Randomized Trial of Cardiovascular Responses to Energy Drink Consumption in Healthy Adults.

Author Affiliations: Center for Surgery and Public Health, Brigham and Women’s Hospital, Boston, Massachusetts (Sammon, Trinh); VUI Center for Outcomes Research, Analytics and Evaluation, Henry Ford Health System, Detroit, Michigan (Abdollah, Menon); Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts (Choueiri, Kantoff); Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts (Nguyen).
Inhibitory effects of isradipine on uterine contractions in pregnant rats

Objective: To investigate the effects of isradipine, which is a calcium channel blocker, on late pregnant rats’ myometrium under in vitro conditions. Methods: Stripes were obtained from the myometriums of pregnant rats which were decapitated on the 18 days of gestation. The effects of isradipine on myometrium were investigated in four groups and four cumulative doses: 1 ng/ml, 10 ng/ml, 0.1 μg/ml, 1 μg/ml. Group 1: spontaneous myometrial contractions, Group II: myometrial contractions induced by oxytocin, Group III: myometrial contractions induced by prostaglandin, Group IV: myometrial contractions induced by oxytocin in calcium-free medium. Wilcoxon signed ranks test was used for the statistical analysis and p<0.05 was considered statistically significant. Results: Group 1: compared to the control group, 10 ng/mL and 0.1 μg/mL isradipine decreased the amplitude of uterine contractions. Group II: 0.1 μg/mL isradipine decreased the frequency of contractions (p=0.02). Isradipine decreased the amplitudes of contractions in the doses of 10 ng/mL and 0.1 μg/mL (p=0.02 for each dose). Group III: 0.1 μg/mL isradipine decreased the frequency of contractions (p=0.02). Isradipine decreased the amplitudes of contractions in the doses of 10 ng/mL and 0.1 μg/mL (p=0.02 for each dose). One μg/mL isradipine completely removed all spontaneous and induced contractions. Group IV: when compared to mediums with calcium, both amplitudes and frequencies of the contractions were found lower in this group (p<0.001). Isradipine was only used in the dose of 1 μg/mL and it completely removed all contractions.
pipsqueak Encodes a Factor Essential for Sequence-Specific Targeting of a Polycomb Group Protein Complex

The Polycomb (Pc) group (Pc-G) of repressors is essential for transcriptional silencing of homeotic genes that determine the axial development of metazoan animals. It is generally believed that the multimeric complexes formed by these proteins nucleate certain chromatin structures to silence promoter activity upon binding to Pc-G response elements (PRE). Little is known, however, about the molecular mechanism involved in sequence-speciﬁc binding of these complexes. Here, we show that an immunoafﬁnity-puriﬁed Pc protein complex contains a DNA binding activity speciﬁc to the (GA) n motif in a PRE from the bithoraxoid region. We found that this activity can be attributed primarily to the large protein isoform encoded by pipsqueak ( psq ) instead of to the well-characterized GAGA factor. The functional relevance of psq to the silencing mechanism is strongly supported by its synergistic interactions with a subset of Pc-G that cause misexpression of homeotic genes. The Hox genes in the Antennapedia complex (ANTP-C) and the bithorax complex (BX-C) of Drosophila melanogaster are essential for segmental speciﬁcation along the anteropos-terior body axis (32, 41). Aberrant expression of these genes often causes homeotic transformation, i.e., misspeciﬁcation of body parts. Complex regulatory mechanisms exist to ensure
Alternative interferons and immunomodulators in the treatment of hepatitis C

Interferon‐α (IFN‐α) has been the mainstay of therapy for hepatitis C and is currently being combined with other drugs to improve the response rate. Newer therapeutic regimens are being developed to spare the use of IFN because of the important side effects associated with IFN‐based therapy. However, there may still be a need for the use of IFN in certain populations. In addition, agents that mimic the actions of IFN but with fewer side effects may still be of major value. This review focuses on the development of alternative and new forms of IFNs and other immunomodulatory agents that may supplant IFN‐α in combination therapy for hepatitis C.
A 3-D Continuous–Discontinuous Galerkin Finite-Element Time-Domain Method for Maxwell's Equations

A 3-D continuous–discontinuous Galerkin (CDG) finite-element time-domain method for Maxwell's equations is proposed to analyze transient electromagnetic problems, which is based on the field variables E and B. This method is aimed at exploiting the advantages of reduced number of unknowns for continuous Galerkin (CG) method and block-diagonal property of discontinuous Galerkin (DG) method. The whole domain is divided into several clusters. The CG is used for the elements in the clusters, and they exchange information with adjacent clusters through traditional numerical fluxes in a DG manner. Moreover, compared to the conventional method based on field variables E and H, the proposed method can eliminate spurious modes. Numerical results demonstrate that the proposed CDG method is superior to the DG method in terms of memory and simulation time.
BER Analysis of OFDM Digital Communication Systems with Improved ICI Cancellation Technique

In this paper, performance of OFDM digital communication systems have been analyzed with improved ICI cancellation technique. The bit error rate has been regarded as a fundamental information theoretic measure of a communication system. A novel parallel ICI cancellation technique has been proposed for mitigating frequency offset of OFDM digital communication systems. The simulated results of the proposed technique is compared with ICI self cancellation scheme. The simulated results show better performance over ICI self cancellation scheme.
Adaptive contention resolution parameters for the IEEE 802.16 networks

In the IEEE 802.16 networks, the base station allocates resources to subscriber stations based on their QoS requirements and bandwidth request sizes. A subscriber station can send a bandwidth request when it has an uplink grant allocated by the base station or by taking part in the contention resolution mechanism. This paper presents analytical calculations for parameters that control the contention resolution process in the IEEE 802.16 networks. In particular, the backoff start/end values and the number of request transmission opportunities are considered. The simulation results confirm the correctness of theoretical calculations. They also reveal that the adaptive parameter tuning results in a better throughput when compared to a static configuration. At the same time, all the timing requirements are met.
Prevalence of Hyperkalemia in Type 2 Diabetics Treated with Inhibitors of the Renin-Angiotensin-Aldosterone System: A Multicenter Study

Background and Aim: Hyperkalemia is a common risk among patients treated with renin-angiotensin-aldosterone system (RAAS) inhibitors, especially diabetics. The aim of this study was to measure the prevalence of hyperkalemia among patients with type-2 diabetics treated with ARBs and/or ACEIs, and compare them with controls. Subjects and methods: This study was carried out in four primary health care centers in Bahrain using a comparative ex-post-facto cross-sectional design with a control group. It included 305 type-2 diabetes patients in these settings. They were categorized into four groups: A) controls not on RAAS medications; B) ARB alone; C) ACE Inhibitors alone; D) combination of both. Data were collected from medical records. The study protocol was approved by the research committee in the Ministry of Health in the Kingdom of Bahrain. Results: The prevalence of hyperkalemia among those on ACE inhibitor and/or ARB medications was 16.51% (95% CI: 11.84 – 22.12%), while severe hyperkalemia was 1.38% (95% CI: 0.28 – 3.97%). The patients in the group taking both ARB and ACE inhibitor medications had significantly higher level of serum potassium but better control of their Fasting Blood Sugar (FBS) compared to the other 3 groups. In multivariate analysis, the medication group was not a statistically significant predictor of hyperkalemia. Conclusion: A combined ACEi/ARB therapy may pose a higher risk of increased serum potassium compared with mono-treatment or control. Hence, caution should be exercised especially in those with advanced kidney disease, heart failure, on renal replacement therapy, on potassium sparing diuretics.
Update on chronic hepatitis C in HIV/HCV-coinfected patients: viral interactions and therapy

With highly active antiretroviral therapy (HAART), HIV-infected patients can now live longer and healthier lives, and other comorbid diseases, such as chronic hepatitis C, have emerged as a significant health concern. Coinfection with the hepatitis C virus (HCV) may limit life expectancy because it can lead to serious liver disease including decompensated liver cirrhosis and hepatocellular carcinoma. HCV-induced fibrosis progresses faster in HIV/HCV-coinfected persons, although HAART may be able to decrease this disease acceleration. Combination therapy for HCV with interferon and ribavirin can achieve a sustained viral response, although at a lower rate than in HCV-monoinfected patients. Combination treatment with pegylated interferon and ribavirin will probably emerge as the next HCV therapy of choice for HIV/HCV-coinfected patients. HCV combination therapy is generally safe, but serious adverse reactions, like lactic acidosis, may occur. Cytopenia may present a problem leading to dose reductions, but the role of growth factors is under study. All HIV/HCV-coinfected patients should be evaluated for therapy against the hepatitis C virus. A sustained viral load will probably lead to regression of liver disease, and even interferon-based treatment without viral clearance may slow down progression of liver disease. HIV/HCV-coinfected patients who have progressed to end-stage liver disease have few therapeutic options other than palliative care, since liver transplants are generally unavailable. The mortality post-transplant may be higher than in HCV-monoinfected patients. We are entering an era where safe and effective HCV therapy is being defined for HIV/HCV-coinfected patients, and all eligible patients should be offered treatment.
Estimating customer reviews in recommender systems using sentiment analysis methods

The paper presents a method for estimating unknown user reviews in terms of which specific aspects of a particular item, such as a restaurant, a user would mention in a review that he/she would write about the item and also which sentiments the user would express about these aspects. Unlike the traditional rating-based recommendation methods, the proposed approach estimates user experiences of an item in terms of the most crucial aspects of the item for the user. Therefore, this approach enables more detailed item recommendations to the user. We apply this method to two real-life review datasets from Yelp to evaluate its performance.
‘LiveJournal Libra!’: The political blogosphere and voting preferences in Russia in 2011–2012

This study explores relationship between the Internet and the Russian national election of 2011–2012. In contrast to other studies, we focus on the blogosphere as a political factor. Our conclusions are based on a study of the LiveJournal blogging platform represented by a sample of political posts from the top 2000 bloggers for 13-week-long periods. Sampling from the population of about 180,000 posts was performed automatically with a topic modelling algorithm, while the analysis of the resulting 3690 texts was carried out manually by five coders. We found that the most influential Russian blogs perform the role of a media ‘stronghold’ of the political opposition. Moreover, we established a relationship between the weekly pre-election ratings of the opposition parties and presidential candidates and the indicators of political activity in the blogosphere. Our results cautiously suggest that political activity on the Internet is not simply an online projection of offline political activity: it can itself provoke activity in offline political life.