Miracle-dz/UniFAR-FTUs huggingface dataset:
Faculty perceptions and knowledge of career development of trainees in biomedical science: What do we (think we) know?

The Broadening Experiences in Scientific Training (BEST) program is an NIH-funded effort testing the impact of career development interventions (e.g. internships, workshops, classes) on biomedical trainees (graduate students and postdoctoral fellows). BEST Programs seek to increase trainees’ knowledge, skills and confidence to explore and pursue expanded career options, as well as to increase training in new skills that enable multiple career pathways. Faculty mentors are vital to a trainee’s professional development, but data about how faculty members of biomedical trainees view the value of, and the time spent on, career development are lacking. Seven BEST institutions investigated this issue by conducting faculty surveys during their BEST experiment. The survey intent was to understand faculty perceptions around professional and career development for their trainees. Two different, complementary surveys were employed, one designed by Michigan State University (MSU) and the other by Vanderbilt University. Faculty (592) across five institutions responded to the MSU survey; 225 faculty members from two institutions responded to the Vanderbilt University survey. Participating faculty were largely tenure track and male; approximately 1/3 had spent time in a professional position outside of academia. Respondents felt a sense of urgency in introducing broad career activities for trainees given a recognized shortage of tenure track positions. They reported believing career development needs are different between a graduate student and postdoctoral fellow, and they indicated that they actively mentor trainees in career development. However, faculty were uncertain as to whether they actually have the knowledge or training to do so effectively. Faculty perceived that trainees themselves lack a knowledge base of skills that are of interest to non-academic employers. Thus, there is a need for exposure and training in such skills. Faculty stated unequivocally that institutional support for career development is important and needed. BEST Programs were considered beneficial to trainees, but the awareness of local BEST Programs and the national BEST Consortium was low at the time surveys were employed at some institutions. It is our hope that the work presented here will increase the awareness of the BEST national effort and the need for further career development for biomedical trainees.
The Effect of Dining Atmospherics to Perceived Value, Customer Satisfaction, and Behavioral Intention With Double Decker Restaurant in Solo Baru as Research Object

The purpose this study is to examine the impact of Dining Atmospherics, Perceived Value, Customer Satisfaction, and Behavioral Intentions in Restaurant Double Decker at Solo Baru, Indonesia. We distribute questionnaires to 150 consumers of Restaurant Double Decker Solo Baru who visited more than three times. Using Structural Equation Model (SEM) assisted by AMOS application program, the results showed that Behavioral Intention have a significant positive influence on the dependent variable that is Atmospherics, and the dependent variable that is Atmospherics also have a significant positive effect on the mediating variable, Customer Satisfaction, and Perceived Value, then the Customer Satisfaction has a significant positive influence on independent variables of Behavioral Intention.
Age and sex related self-reported symptoms in a general population across 30 years: Patterns of reporting and secular trend

Objective To study age and sex specific prevalence of 30 symptoms in random samples from the general population and to analyze possible secular trends across time. Study population The study was based on data from eight on-going Swedish cohort studies, with baseline investigations performed between 1973 and 2003. Samples were drawn from the general population of the cities of Gothenburg and Eskilstuna, and of Uppsala County. Overall, 20,160 subjects were sampled, 14,470 (71.8%) responded, of whom 12.000 were unique subjects, and 2548 were part of more than one sample. Methods The Complaint score sub-scale of the Gothenburg Quality of Life instrument, listing 30 general symptoms was used. Responders were asked to indicate which symptoms they had experienced during the last three months. Results Women reported on average 7.8 symptoms, and men 5.3 (p<0.0001). Women reported higher prevalence than men for 24 of the 30 symptoms. In multivariate analyses four patterns of prevalence across age were identified in both men and women; increasing prevalence, decreasing, stable and biphasic prevalence. The symptoms in the various pattern groups differed somewhat between men and women. However, symptoms related to strain were prominent among symptoms decreasing with age. Moreover, there were secular trends. Across all symptoms reporting prevalence increased over time in men (p<0.001) as well as in women (p<0.0001). Conclusions Women reported higher total symptom prevalence than men. Symptoms related to health generally increased with age, while symptoms related to stress decreased markedly. Significant secular trends across time regarding symptom prevalence were found.
Population genetic structure of the Mediterranean horseshoe bat Rhinolophus euryale in the central Balkans

Migratory behaviour, sociality and roost selection have a great impact on the population structure of one species. Many bat species live in groups, and movements between summer and hibernation sites are common in temperate bats. The Mediterranean horseshoe bat Rhinolophus euryale is a cave-dwelling species that exhibits roost philopatry and undertakes seasonal movements which are usually shorter than 50 km. Its distribution in Serbia is restricted to karstic areas in western and eastern parts of the country, with a lack of known roosts between them. In this study, microsatellite markers were used to evaluate genetic variation in this species in the Central Balkans. Specifically, spatial genetic structuring between geographic regions and relatedness within different colony types were assessed. All analysed loci were polymorphic, and there was no significant inbreeding coefficient recorded. A moderate degree of genetic differentiation among the sampled colonies was found, and significant isolation by distance was recorded. Our results revealed that populations show a tendency to segregate into three clusters. Unexpectedly, populations from Montenegro and Eastern Serbia tended to group into one cluster, while populations from Western Serbia and Slovenia represented second and third cluster, respectively. The majority of variance was partitioned within colonies, and only a small but significant portion among clusters. Average relatedness within colony members was close to zero, did not differ significantly between the different colony types, and kinship is unlikely to be a major grouping mechanism in this species.
Double Trouble: How Being Outnumbered and Negatively Stereotyped Threatens Career Outcomes of Women in STEM

Masculine work contexts form an important source of social identity threat for working women. But what aspect of masculine work contexts is most threatening to women’s gender identity at work: A numerical majority of male colleagues (i.e., numerical male dominance), working in a profession in which women are negatively stereotyped (i.e., normative male dominance), or the combination? The current study aimed to disentangle these two aspects of masculine work contexts by testing its combined impact on the experience of gender identity threat among women and men who work in the STEM sector (i.e., Science, Technology, Engineering and Mathematics). A field study was conducted among women (N = 177) and men (N = 630) graduates holding an academic degree in a STEM educational program. Respondents either worked in- or outside the STEM sector (i.e., stronger vs. weaker gender stereotype) and estimated the ratio of men to women in their direct work environment. Results from a Structural Equation Model demonstrated that women in STEM face double trouble: The combination of working almost solely with male colleagues (being outnumbered) and working in the technical sector (where women are negatively stereotyped) predicted the highest levels of experienced gender identity threat, particularly among women who highly identified with their gender group. Gender identity threat, in turn, negatively predicted women’s work engagement and career confidence. Men did not face double trouble: Their experience of gender identity threat was not related to working in a masculine STEM sector. Importantly, considering that the women in this sample already hold a degree in STEM, and have proven their competence in STEM and resilience to gender stereotypes, this research reveals how in naturalistic work settings, prevailing social identity threats continue to affect women’s professional careers.
Study on feeding effect of dietary protein sources of on blood or milk urea nitrogen in native cows

A feeding trial with 30 Pabna milking cows of 2 to 4 parities dividing equally into 5 groups was conducted to determine the effect of feeding protein from different sources on blood or milk urea nitrogen, and milk yield or protein content in native cows. Considering a group of cows fed a diet of rice straw and concentrate as the control (T 0 ), two out of the rests were fed either with urea-molasses straw (UMS) (T 1 ) or Matikalai ( Vigna mungo ) hay ( T 2 ) as sources of basal roughage. The rest two groups of cows were fed the control diet replacing percent (%) of feed protein by the amount of urea and molasses fed to UMS group. The amount of urea and molasses was fed daily either in two meals (T 3 ) or fed to cows mixing with other concentrate feed (T 4 ). Feeding a basal diet of UMS, DS or leguminous hay did not affect milk protein (%) and daily milk production Feeding urea and molasses in meals or mix (T 3 and T 4 ) did not affect significantly (p>0.05) BSU and MUN contents. It indicates that feeding urea and molasses in two meals in a day either as a single mix of the two or as a mix of the two with concentrates significantly (p>0.05) reduced the concentration of BSU or MUN without having any change in milk protein (%) of the cows. Dry matter (DM) intake was significantly (p<0.05) higher in T 1 treatment group followed by T 4 , T 0 , T 3 and T 2 , respectively. Similarly, CP intake was significantly (p<0.05) higher in T 1 and T 2 treatment groups followed by T 3 and T 4 treatment groups. The values of CP intake were 490, 770, 760, 630 and 580 g/day for treatment groups T 0 , T 1 , T 2 , T 3 , and T 4 , respectively. Feedings urea and molasses as meals (T 3 ) significantly (p<0.05) reduced the fat content in milk compared with other treatment groups. Similar to T 3 , UMS feeding also significantly (p<0.05) reduced fat content in milk compared to Matikalai hay and T 4 treatment groups. Milk urea nitrogen (MUN) content in morning milk was lower compared to evening milk. These data showed that feeding urea or protein of organic sources had effect on BSU and MUN contents in the morning milk but had no significant effect on evening milk. The lower BSU or MUN content in milk of the cows fed urea and molasses either in daily meals or as mix with concentrates may be due mainly to a lower CP intake compared to UMS and Matikalai. Therefore, it may be concluded that feeding urea or organic protein had no significant effect on milk protein percent . Bangladesh J. of Livestock Res. 19(1-2): 85-96, Jan-Dec 2012
Teaching word processing - the theory behind

It is widely thought and believed that word processors – especially MS Word – are software, which everyone can use. However, if we take a closer look at the documents we find that the picture is not at all that clear. In most of these documents even the basic rules of word processing are broken. The question is how it is possible that most of the users are satisfied with their performance, and do not realize that they only use a less noisy typewriter, and not able to take advantage of the opportunities offered by these software. In the search of clearing this misunderstanding I found that there are no publicly available sources, which would clearly set the rules to determine when the documents are properly formatted. Here I set three maxims which, together, are able to control the tools applied in word processing in order to create properly formatted texts. In summary, they state that the layout of a properly formatted text should be invariant to modification, that is, any modification of the body of text should not initiate its re-formatting. To prove that these maxims work and to show that we desperately need them I give examples of works of professionals from the administration, of those who passed ecdl exams, of teachers of various subjects, and finally of teachers of Informatics.
Vamorolone targets dual nuclear receptors to treat inflammation and dystrophic cardiomyopathy

Vamorolone is a first-in-class dissociative drug that selectively targets the glucocorticoid receptor to safely treat chronic inflammation and the mineralocorticoid receptor to treat cardiomyopathy, providing efficacy with improved safety in mouse models of Duchenne muscular dystrophy. Cardiomyopathy is a leading cause of death for Duchenne muscular dystrophy. Here, we find that the mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) can share common ligands but play distinct roles in dystrophic heart and skeletal muscle pathophysiology. Comparisons of their ligand structures indicate that the Δ9,11 modification of the first-in-class drug vamorolone enables it to avoid interaction with a conserved receptor residue (N770/N564), which would otherwise activate transcription factor properties of both receptors. Reporter assays show that vamorolone and eplerenone are MR antagonists, whereas prednisolone is an MR agonist. Macrophages, cardiomyocytes, and CRISPR knockout myoblasts show vamorolone is also a dissociative GR ligand that inhibits inflammation with improved safety over prednisone and GR-specific deflazacort. In mice, hyperaldosteronism activates MR-driven hypertension and kidney phenotypes. We find that genetic dystrophin loss provides a second hit for MR-mediated cardiomyopathy in Duchenne muscular dystrophy model mice, as aldosterone worsens fibrosis, mass and dysfunction phenotypes. Vamorolone successfully prevents MR-activated phenotypes, whereas prednisolone activates negative MR and GR effects. In conclusion, vamorolone targets dual nuclear receptors to treat inflammation and cardiomyopathy with improved safety.
The water chemistry of some shallow lakes in Northern Patagonia and their nitrogen status in comparison with remote lakes in different regions of the globe

Eighteen small shallow lakes located in the Northern Patagonian Lake District, in southern South America, were sampled in 2001 and analysed for the main chemical variables (pH, conductivity, alkalinity, major ions and nutrients). The study lakes span a wide geographical and altitudinal range and belong partly to the Pacific and partly to the Atlantic watershed. The main aim of this study was to investigate the relationships between water chemistry and physical/geographical properties of these lakes. Secondly, the nitrogen content of the lakes was considered in detail, and results compared to those obtained in previous studies carried out in other remote areas of the globe (the Central Southern Alps in Italy, the Sierra da Estrela region in Portugal, the Svalbard Islands in the Arctic, the Khumbu-Himal region in Nepal, and the Terra Nova Bay area in Antarctica). In the Alps, lakes are characterised by markedly high nitrogen concentrations, manly as nitrate, due to the high inputs of nitrogen compounds from downwind sources like the Po Plain in Northern Italy. Conversely, lakes at remote locations such as the Andes, Antarctica and Himalaya are characterised by a low nitrogen content, mainly as organic nitrogen. This status is related to the limited atmospheric inputs of nitrogen affecting these regions.
An investigation of the cross-mode comparability of a paper and computer-based multiple-choice cloze reading assessment for ESL learners

This study was designed to determine whether a computer-based version of a standardized cloze reading test for second language learners is comparable to its traditional paper-based counterpart and to identify how test takers’ computer familiarity and perceptions of paper and computer-based tests related to their performance across testing modes. Previous comparability research for second language speakers revealed that some studies found that the two forms are comparable while others found they are not. Findings on the connection between computer attitudes and computer test performance were also mixed. One hundred and twenty high school ELL students were recruited for the study. The research instruments included both paper and computer-based versions of a locally developed reading assessment. The two tests are the same in terms of content, questions,pagination and layout. The design was a Latin squares so that two groups of learners took the tests in the opposite order and their scores were compared. Participants were also asked to complete questionnaires about their familiarity with computers and their perceptions of each of the two testing modes. Results indicate that the paper and computer-based versions of the test are comparable. A regression analysis showed that there is a relationship between computer familiarity and computer-based LOMERA performance. Mode preference survey data pointed to differences in preferences depending on each unique test feature. These results help validate the cross-mode comparability of assessments outside of the traditional discrete point multiple choice tests which tends to predominate in current research.
Outcomes and implementation challenges of using daily treatment regimens with an innovative adherence support tool among HIV-infected tuberculosis patients in Karnataka, India: a mixed-methods study

ABSTRACT Background: In India, a new care package consisting of (i) daily regimen with fixed-dose combination drugs, collected once-a-month and self-administered by the patient, (ii) ‘one stop service’ at antiretroviral treatment (ART) centre for both HIV and tuberculosis (TB) treatment and (iii) technology-enabled adherence support (99DOTS, which required patients to give a missed phone call after consuming drugs) was piloted for treatment of TB among HIV-infected TB patients. Conventional care included intermittent regimen (drugs consumed thrice-weekly) delivered under direct observation of treatment supporter and the patients needing to visit TB and HIV care facilities, separately for treatment. Objective: To assess the effect of new care package on TB treatment outcomes among HIV-TB patients registered during January–December 2016, as compared to conventional care and explore the implementation challenges. Methods: A mixed-methods study was conducted in four districts of Karnataka, India where new care package was piloted in few ART centres while the rest provided conventional care. Quantitative component involved a secondary cohort analysis of routine programme data. Adjusted relative risk(aRR) was calculated using Poisson regression to measure association between new care package and unsuccessful treatment outcome. We conducted in-depth interviews with healthcare providers and patients to understand the challenges. Results: Unsuccessful TB treatment outcomes (death, loss to follow-up and failure) were higher in new care package (n = 871) compared to conventional care (n = 961) (30.5% vs 23.4%; P value<0.001) and aRR was 1.3(95% CI: 1.1–1.7). Key challenges included patients’ inability to give missed call, increased work load for ART staff, reduced patient–provider interaction, deficiencies in training and lack of role clarity among providers and reduced involvement of TB program staff. Conclusion: With new care package, TB treatment outcomes did not improve as expected and conversely declined compared to conventional care. TB and HIV programs need to address the operational challenges to improve the outcomes.
Canakinumab: can it untie the Gordian knot of cardiovascular disease in patients with familial Mediterranean fever?

Corresponding author: Dimitrios Ioannis Patoulias Second Propedeutic Department of Internal Medicine General Hospital Hippokration Aristotle University of Thessaloniki 3 B M. Alexandrou St 57010 Thessaloniki, Greece Phone: +30 6946900777 E-mail: dipatoulias@gmail. com Second Propedeutic Department of Internal Medicine, General Hospital Hippokration, Aristotle University of Thessaloniki, Thessaloniki, Greece
Eventive and stative passives in Spanish L2 acquisition: A matter of aspect*

This paper reports on an empirical study that examined knowledge of eventive and stative passives in the L2 Spanish grammar of L1 speakers of English. Although the two types of passive exist in English, the difference between them is not signaled in any specific way. In Spanish, in contrast, the distinction is marked by the choice of copula: ser is used to form eventive passives, estar for statives. Researchers agree that the two copulas, both of which translate as English “to be”, differ in relation to aspect: estar is perfective while ser is not marked for aspect (Schmitt, 1992). The question was whether L2 learners would be able to acquire the aspectual difference of the copulas and apply it to the formation of the passives. Two main tests were used, a Grammaticality Judgment Task and a Sentence Selection Task. The Grammaticality Judgment Task examined properties of the passives related, among other things, to aspect and agentivity. The Sentence Selection Task focused on the interpretation of the subject: only the subject of ser can be interpreted as generic. Although the learners in general distinguished between grammatical and ungrammatical sentences, they had not acquired the restriction on subject interpretation. These results are explained in terms of interfaces.
Advanced control for floating offshore wind turbines

Los aerogeneradores flotantes presentan diversos retos tecnologicos, entre los cuales, las atenuaciones de la dinamica producida por el empuje del viento y la inducida por el oleaje, debido a la baja rigidez hidrodinamica de la plataforma, son vitales. Estas dinamicas no solo influyen en el funcionamiento normal del aerogenerador, sino que ademas, incrementan las cargas mecanicas de algunos componentes, como la torre y palas del aerogenerador. Por ello, el objetivo de esta tesis es minimizar las dinamicas de los aerogeneradores flotantes, mejorando el funcionamiento a la vez que se reducen las cargas mecanicas producidas en la torre y palas mediante tecnicas de control avanzadas, y asi, aumentar la eficiencia del aerogenerador y prolongar la vida util de dichos componentes.La descripcion del trabajo incluye el modelado de plataformas flotantes y el desarrollo de dos lazos de control, que respectivamente realimentan la velocidad de la gondola y los momentos flectores en las raices de las palas, para la contribucion en la regulacion del angulo de pitch de las palas del aerogenerador. Ademas, se estudia la relacion de las dimensiones de las plataformas flotantes y el desempeno del controlador disenado con el fin de reducir las dimensiones de la plataforma manteniendo las propiedades del funcionamiento del aerogenerador. Se proponen dos metodos innovadores para la linealizacion de los modelos no lineales de aerogeneradores flotantes y la optimizacion de los lazos de control disenados en esta tesis. Los resultados mostrados demuestran la eficacia del controlador disenado en la consecucion de los objetivos propuestos.