Miracle-dz/UniFAR-FTUs huggingface dataset:
On beauty : [a history of western idea]

Introduction. Comparative Tables. The Aesthetic Ideal in Ancient Greece. Apollonian and Dionysiac. Beauty as Proportion and Harmony. Light and Colour in the Middle Ages. The Beauty of Monsters. From the Pastourelle to the Donna Angelicata. Magic Beauty between the Fifteenth and Sixteenth Centuries. Ladies and Heroes. From Grace to Disquieting Beauty. Reason and Beauty. The Sublime. Romantic Beauty. The Religion of Beauty. The New Object. The Beauty of Machines. From Abstract Forms to the Depths of Material. The Beauty of the Media. Bibliographic References of Translations. Index of Authors. Index of Artists.
Probabilistic Attribute Tree in Convolutional Neural Networks for Facial Expression Recognition

In this paper, we proposed a novel Probabilistic Attribute Tree-CNN (PAT-CNN) to explicitly deal with the large intra-class variations caused by identity-related attributes, e.g., age, race, and gender. Specifically, a novel PAT module with an associated PAT loss was proposed to learn features in a hierarchical tree structure organized according to attributes, where the final features are less affected by the attributes. Then, expression-related features are extracted from leaf nodes. Samples are probabilistically assigned to tree nodes at different levels such that expression-related features can be learned from all samples weighted by probabilities. We further proposed a semi-supervised strategy to learn the PAT-CNN from limited attribute-annotated samples to make the best use of available data. Experimental results on five facial expression datasets have demonstrated that the proposed PAT-CNN outperforms the baseline models by explicitly modeling attributes. More impressively, the PAT-CNN using a single model achieves the best performance for faces in the wild on the SFEW dataset, compared with the state-of-the-art methods using an ensemble of hundreds of CNNs.
HDAC inhibition in glioblastoma monitored by hyperpolarized 13C MRSI

Vorinostat is a histone deacetylase (HDAC) inhibitor that inhibits cell proliferation and induces apoptosis in solid tumors, and is in clinical trials for the treatment of glioblastoma (GBM). The goal of this study was to assess whether hyperpolarized 13C MRS and magnetic resonance spectroscopic imaging (MRSI) can detect HDAC inhibition in GBM models. First, we confirmed HDAC inhibition in U87 GBM cells and evaluated real‐time dynamic metabolic changes using a bioreactor system with live vorinostat‐treated or control cells. We found a significant 40% decrease in the 13C MRS‐detectable ratio of hyperpolarized [1‐13C]lactate to hyperpolarized [1‐13C]pyruvate, [1‐13C]Lac/Pyr, and a 37% decrease in the pseudo‐rate constant, kPL, for hyperpolarized [1‐13C]lactate production, in vorinostat‐treated cells compared with controls. To understand the underlying mechanism for this finding, we assessed the expression and activity of lactate dehydrogenase (LDH) (which catalyzes the pyruvate to lactate conversion), its associated cofactor nicotinamide adenine dinucleotide, the expression of monocarboxylate transporters (MCTs) MCT1 and MCT4 (which shuttle pyruvate and lactate in and out of the cell) and intracellular lactate levels. We found that the most likely explanation for our finding that hyperpolarized lactate is reduced in treated cells is a 30% reduction in intracellular lactate levels that occurs as a result of increased expression of both MCT1 and MCT4 in vorinostat‐treated cells. In vivo 13C MRSI studies of orthotopic tumors in mice also showed a significant 52% decrease in hyperpolarized [1‐13C]Lac/Pyr when comparing vorinostat‐treated U87 GBM tumors with controls, and, as in the cell studies, this metabolic finding was associated with increased MCT1 and MCT4 expression in HDAC‐inhibited tumors. Thus, the 13C MRSI‐detectable decrease in hyperpolarized [1‐13C]lactate production could serve as a biomarker of response to HDAC inhibitors.
Discrimination of Emotional Type by Heartbeat Signal Information

Information obtained from heartbeat signal that is associated with emotional responses was extracted and discriminant model for estimating the type of emotion from the information was developed. In healthy subjects, ECG was recorded continuously during watching movies, during which they pressed a button according to the type of emotion. Power concentration of high-frequency (HF, 0.15–0.45 Hz) component (Hsi) that reflects regularity of respiration, the standard deviation of the amplitude of HF component, and the amplitude of low-frequency (LF, 0.04–0.15 Hz) were extracted as the useful discriminator for the type of emotion. Canonical discriminant model with these variables revealed that periods with joy, worry, sorrow, surprise, and aversion are expanded separately on a plane consisting of two canonical variables reflecting the levels of valence and arousal, respectively.
360-degree suture trabeculotomy ab interno with phacoemulsification in open-angle glaucoma and coexisting cataract: a pilot study

Objective We performed a pilot trial to evaluate the 24-month safety and efficacy of 360-degree suture trabeculotomy ab interno with phacoemulsification used to treat mild to moderate open-angle glaucoma coexisting with cataract. Methods and analysis We randomly assigned 18 eyes with open-angle glaucoma and coexisting cataract to undergo 360-degree suture trabeculotomy ab interno with phacoemulsification (combined) or phacoemulsification alone (control) (1:1 ratio) and followed up patients for 24 months. Main outcome measures were mean postoperative intraocular pressure (IOP) and success probabilities based on Kaplan-Meier life table analyses. Surgical success was defined as follows: criterion A: IOP value ≥6 mm Hg and ≤15 mm Hg, with ≥20 % reduction without medication; criterion B: IOP value ≥6 mm Hg and ≤12 mm Hg, with ≥30% reduction without medication. Secondary outcome measures included the number of medications, complications and best-corrected visual acuity. Results Mean IOP values (number of medications), which were 18.4 mm Hg (0.9) and 17.1 mm Hg (1.3) at baseline, showed significant reductions to 11.8 mm Hg (1.0) and 14.6 mm Hg (1.5) at 24 months postoperatively in the combined and control groups, respectively (p=0.0003 and 0.0192, respectively). Success rates for criterion A in the combined and control groups were 77.8% and 11.1%, respectively (p=0.0110) and those for criterion B in the combined and control groups were 46.7% and 0%, respectively (p=0.0036). Both groups had a similar overall occurrence of postoperative complications. Conclusion Using 360-degree suture trabeculotomy ab interno with phacoemulsification appeared to be a more beneficial option for mild to moderate open-angle glaucoma with coexisting cataract than phacoemulsification alone. Trial registration number UMIN000021170, date of registration: 2016/03/01.
Effect of the Living Environment on falls among the Elderly in Urmia

BACKGROUND: The living environment has an impact on the health of the elderly, and the safety of the house is one of the concerns of the elderly. Disregarding the safety concerns increases the falling. AIM: This research was conducted with the aim of influencing the living environment on falls among elderly people in Urmia city. METHODS: This is a cross-sectional (descriptive-analytic) study which 200 elderly people were selected by random cluster sampling. Data were collected by using a two-part questionnaire including demographic information, and home safety assessment checklist. Data were analysed by using chi-square test and logistic regression in SPSS v. 21 software. RESULTS: The incidence of falling in the elderly was 30%. There was a significant statistical association with age, sex, marital status and history of chronic disease. Results of logistic regression showed non-safe stairs (OR = 1.1, p = 0.002), unsafe toilet/bath (OR = 1.3, p = 0.001), unsafe bedrooms (OR = 1.7, p = 0.05) unsafe living room (OR = 1.4, p = 0.02) increase the falls in the elderly, as well as male gender (OR = 1.14, p < 0.001) and living with other people (OR = 0.19, p = 0.002) reduce the falls in the elderly. CONCLUSION: By identifying the risk factors of the physical space of the home, we can plan for implementing necessary interventions according to the risk factor or risk factors to prevent and reduce the falls in the elderly community.
Innovative Scattering Measurement System in W-Band

We present an innovative system dedicated to millimeter wave scattering measurements in W-band. The principal innovations are the high-precision swivel arm, use of a semi-anechoic environment, flexibility for positioning the object under study, and post-processing to correct measurement errors. Different test objects are used for evaluating the performance of the system for VV- and HH-polarizations.
Evaluation of endogenous reference genes in Bactrocera cucurbitae by qPCR under different conditions

Bactrocera cucurbitae (melon flies) are prominent invasive pests in southern China. To screen for a stable reference gene in melon flies suitable for comparing tissue samples subjected to different conditions in four categories (temperature, insect stage, days of age and gender), the expression of 12 candidate reference genes under different treatment conditions was analyzed by real-time fluorescent quantitative PCR. The results obtained from a comprehensive analysis with geNorm, NormFinder, BestKeeper and RefFinder software showed that the most stable reference gene was RPL60, and the least stable reference gene was actin-5. We used a heat shock protein gene (HSP-90) to verify the results, and the conclusion was consistent. When the reference gene RPL60 was used as the reference gene, the relative expression of HSP-90 was essentially constant with the prolongation of treatment time. When actin-5 was used, HSP-90 expression changed markedly with treatment time. The results of this study can be used for further research on gene expression inBactrocera cucurbitae.
The structure of human apolipoprotein C-1 in four different crystal forms

Human apolipoprotein C1 (APOC1) is a 57 amino acid long polypeptide that, through its potent inhibition of cholesteryl ester transferase protein, helps regulate the transfer of lipids between lipid particles. We have now determined the structure of APOC1 in four crystal forms by X-ray diffraction. A molecule of APOC1 is a single, slightly bent, α-helix having 13–14 turns and a length of about 80 Å. APOC1 exists as a dimer, but the dimers are not the same in the four crystals. In two monoclinic crystals, two helices closely engage one another in an antiparallel fashion. The interactions between monomers are almost entirely hydrophobic with sparse electrostatic complements. In the third monoclinic crystal, the two monomers spread at one end of the dimer, like a scissor opening, and, by translation along the crystallographic a axis, form a continuous, contiguous sheet through the crystal. In the orthorhombic crystals, two molecules of APOC1 are related by a noncrystallographic 2-fold axis to create an arc of about 120 Å length. This symmetrical dimer utilizes interactions not present in dimers of the monoclinic crystals. Versatility of APOC1 monomer association shown by these crystals is suggestive of physiological function.
Postdischarge outcome after Takotsubo syndrome compared with patients post-ACS and those without prior CVD: ANZACS-QI 19

Objective Takotsubo syndrome (TS) mimics acute coronary syndrome (ACS) but has a distinct pathophysiology. While in-hospital adverse outcomes appear similar to those presenting with an ACS, data on longer term postdischarge risk are conflicting. This study sought to assess the long-term prognosis of patients discharged alive after TS. Methods The clinical profile and in-hospital and long-term outcomes were prospectively assessed in consecutive patients with TS. Survival in patients with TS was compared with two representative age-matched and gender-matched comparison cohorts: a hospitalised ACS cohort and a community cohort without known cardiovascular disease (CVD). Results Two hundred and-twenty-five patients with TS (216 women, mean age 63.7±11.8 years) were included. In-hospital mortality was 1.8% and 1.9% for patients with TS and ACS, respectively. Of the 219 patients with TS with postdischarge follow-up, at a mean follow-up of 4.8±3.2 years, there were 19 (8.3%) deaths, 18 of which were from non-cardiac causes. When compared with the cohort without prior CVD, postdischarge patients with TS were at increased mortality risk (HR 2.00, 95% CI 1.26 to 3.17, p=0.003), but mortality in postdischarge patients with ACS was over threefold higher (HR 3.43, 95% CI 2.97 to 3.96, p<0.0001). Conclusions In-hospital mortality for patients diagnosed with TS and ACS was similar. However, while postdischarge survivors of TS had a long-term survival which was poorer than for a community-based cohort without known CVD, their survival was better than for postdischarge survivors of an ACS event. Late deaths in patients with TS were almost all from non-cardiac causes.
The Boundaries of Trust: Cross-Religious and Cross-Ethnic Field Experiments in Mauritius

Several prominent evolutionary theories contend that religion was critical to the emergence of large-scale societies and encourages cooperation in contemporary complex groups. These theories argue that religious systems provide a reliable mechanism for finding trustworthy anonymous individuals under conditions of risk. In support, studies find that people displaying cues of religious identity are more likely to be trusted by anonymous coreligionists. However, recent research has found that displays of religious commitment can increase trust across religious divides. These findings are puzzling from the perspective that religion emerges to regulate coalitions. To date, these issues have not been investigated outside of American undergraduate samples nor have studies considered how religious identities interact with other essential group-membership signals, such as ancestry, to affect intergroup trust. Here, we address these issues and compare religious identity, ancestry, and trust among and between Christians and Hindus living in Mauritius. Ninety-seven participants rated the trustworthiness of faces, and in a modified trust game distributed money among these faces, which varied according to religious and ethnic identity. In contrast to previous research, we find that markers of religious identity increase monetary investments only among in-group members and not across religious divides. Moreover, out-group religious markers on faces of in-group ancestry decrease reported trustworthiness. These findings run counter to recent studies collected in the United States and suggest that local socioecologies influence the relationships between religion and trust. We conclude with suggestions for future research and a discussion of the challenges of conducting field experiments with remote populations.
IGNITE4: Results of a Phase 3, Randomized, Multicenter, Prospective Trial of Eravacycline vs Meropenem in the Treatment of Complicated Intraabdominal Infections

Abstract Background Increasing antimicrobial resistance among pathogens that cause complicated intraabdominal infections (cIAIs) supports the development of new antimicrobials. Eravacycline, a novel member of the fluorocycline family, is active against multidrug-resistant bacteria including extended-spectrum β-lactamase (ESBL) and carbapenem-resistant Enterobacteriaceae. Methods IGNITE4 was a prospective, randomized, double-blind trial. Hospitalized patients with cIAI received either eravacycline 1 mg/kg every 12 hours or meropenem 1 g every 8 hours intravenously for 4–14 days. The primary objective was to demonstrate statistical noninferiority (NI) in clinical cure rates at the test-of-cure visit (25–31 days from start of therapy) in the microbiological intent-to-treat population using a NI margin of 12.5%. Microbiological outcomes and safety were also evaluated. Results Eravacycline was noninferior to meropenem in the primary endpoint (177/195 [90.8%] vs 187/205 [91.2%]; difference, –0.5%; 95% confidence interval [CI], –6.3 to 5.3), exceeding the prespecified margin. Secondary endpoints included clinical cure rates in the modified ITT population (231/250 [92.4%] vs 228/249 [91.6%]; difference, 0.8; 95% CI, –4.1, 5.8) and the clinically evaluable population (218/225 [96.9%] vs 222/231 [96.1%]; (difference, 0.8; 95% CI –2.9, 4.5). In patients with ESBL-producing Enterobacteriaceae, clinical cure rates were 87.5% (14/16) and 84.6% (11/13) in the eravacycline and meropenem groups, respectively. Eravacycline had relatively low rates of adverse events for a drug of this class, with less than 5%, 4%, and 3% of patients experiencing nausea, vomiting, and diarrhea, respectively. Conclusions Treatment with eravacycline was noninferior to meropenem in adult patients with cIAI, including infections caused by resistant pathogens. Clinical Trials Registration NCT01844856.
Speedup of EMT simulations by using an integration scheme enriched with a predictive Fourier coefficients estimator

In this paper, we present a new version of the Sinusoidal Predictor Method, whose objective is to accelerate the EMT simulations of AC power systems. More precisely, it aims at using larger time steps to integrate the arising systems of differential algebraic equations. Contrary to main of the existing approaches, the SPM takes into account the sinusoidal behavior of oscillating components in the solver instead of the modeling part and so does not modify the original equations representing the simulated system. This methodology, which combines an estimation method with an adaptive step size integration scheme, allows us to use a wide range of step sizes varying from 1 μs in transients to 100 ms in steady-state. In this new version of the SPM, modifications have been provided to the estimation step: henceforth, the Fourier coefficients are computed by optimizing a measurement of the system stationarity. As a result, the number of iterations used for simulating a system is dramatically reduced compared to a standard integration scheme, especially in steady-state and during slow dynamics.
Early Life Body Size in Relation to First Intracerebral or Subarachnoid Hemorrhage

Background and Purpose As risk of hemorrhagic stroke may have early life origins, we investigated associations of birth weight and childhood body mass index (BMI) with adult intracerebral hemorrhage (ICH) or subarachnoid hemorrhage (SAH). Methods We included 240,234 Danish schoolchildren, born 1936 to 1989, with information on birth weight and measured weights and heights from 7 to 13 years. We calculated hazard ratios (HRs) and confidence intervals (CIs) for the associations between early life anthropometrics and ICH or SAH, identified through linkage with national registers. Results During the study period, 1,947 individuals (39% women) experienced an ICH and 797 individuals (64% women) experienced a SAH. Per 500 g increase in birth weight, women had a 10% decreased risk of SAH (HR, 0.90; 95% CI, 0.83 to 0.97) and men had a 10% decreased risk of ICH (HR, 0.90; 95% CI, 0.85 to 0.95). Birth weight was not associated with risks of ICH in women or SAH in men. In men, a childhood BMI below average (BMI z-score <0) was associated with increased risks of ICH. The association was stronger at older childhood ages, and at 13 years a BMI z-score of –1 was associated with a HR of 1.17 (95% CI, 1.06 to 1.28), and a BMI z-score of –2 with a HR of 1.46 (95% CI, 1.17 to 1.82) for ICH. Childhood BMI was not associated with risks of ICH in women or with risks of SAH in both sexes. Conclusions Early life body size is associated with ICH and SAH, and the associations differ by sex.
A probabilistic metric for the validation of computational models

A new validation metric is proposed that combines the use of a threshold based on the uncertainty in the measurement data with a normalized relative error, and that is robust in the presence of large variations in the data. The outcome from the metric is the probability that a model's predictions are representative of the real world based on the specific conditions and confidence level pertaining to the experiment from which the measurements were acquired. Relative error metrics are traditionally designed for use with a series of data values, but orthogonal decomposition has been employed to reduce the dimensionality of data matrices to feature vectors so that the metric can be applied to fields of data. Three previously published case studies are employed to demonstrate the efficacy of this quantitative approach to the validation process in the discipline of structural analysis, for which historical data were available; however, the concept could be applied to a wide range of disciplines and sectors where modelling and simulation play a pivotal role.
Novel insights into the pharmacometabonomics of first-line tuberculosis drugs relating to metabolism, mechanism of action and drug-resistance

Abstract The World Health Organization recommends the directly observed therapy short-course (DOTS) regimen, a combination of four first-line antibiotics (isoniazid, rifampicin, pyrazinamide and ethambutol), for the treatment of active pulmonary tuberculosis (TB). However, despite the fact that this treatment regimen is commonly used worldwide, the metabolism and anti-bacterial mechanisms of these drugs are not yet fully understood. This lack of information ultimately contributes to the poor patient compliance and the subsequent treatment failure and post treatment relapse seen in some TB patients. Pharmacometabonomics, the latest addition to the omics research domain, focuses on the identification of drug-induced metabolome variations. The observed metabolite changes can be used to better understand drug metabolism, drug action and drug-resistance mechanisms. In this review, we summarize the generally known biological mechanisms of the first-line TB drugs included in the DOTS program, and we additionally elaborate on the contribution that pharmacometabonomics has made to the expansion of this knowledge.
Differential Regulation of Thermodynamic Binding Forces of Levocetirizine and (S)-Cetirizine by Lys191 in Human Histamine H1 Receptors

Cetirizine is a zwitterionic second-generation antihistamine containing R- and S-enantiomers, levocetirizine, and (S)-cetirizine. Levocetirizine is known to have a higher affinity for the histamine H1 receptors than (S)-cetirizine; ligand-receptor docking simulations have suggested the importance of the formation of a salt bridge (electrostatic interaction) between the carboxylic group of levocetirizine and the Lys191 residue at the fifth transmembrane domain of human histamine H1 receptors. In this study, we evaluated the roles of Lys191 in the regulation of the thermodynamic binding forces of levocetirizine in comparison with (S)-cetirizine. The binding enthalpy and entropy of these compounds were estimated from the van ‘t Hoff equation, by using the dissociation constants obtained from their displacement curves against the binding of [3H]mepyramine to the membrane preparations of Chinese hamster ovary cells expressing wild-type human H1 receptors and their Lys191 mutants to alanine at various temperatures. We found that the higher binding affinity of wild-type H1 receptors for levocetirizine than (S)-cetirizine was achieved by stronger forces of entropy-dependent hydrophobic binding of levocetirizine. The mutation of Lys191 to alanine reduced the affinities for levocetirizine and (S)-cetirizine, through a reduction in the entropy-dependent hydrophobic binding forces of levocetirizine and the enthalpy-dependent electrostatic binding forces of (S)-cetirizine. These results suggested that Lys191 differentially regulates the binding enthalpy and entropy of these enantiomers, and that Lys191 negatively regulates the enthalpy-dependent electrostatic binding forces of levocetirizine, contrary to the predictions derived from the ligand-receptor docking simulations.