Miracle-dz/UniFAR-FTUs huggingface dataset:
Ambulatory stress psychophysiology: the study of “compensatory and defensive counterforces” and conflict in a natural setting.

&NA; Thirty years ago, Donald Oken raised basic questions about psychophysiological research strategies for the study of the “psychological stress response” in the laboratory. Is it possible to simulate in the laboratory the situations one normally encounters? Do laboratory stimuli provoke affective arousal? Are different classes of stress stimuli associated with specific physiological response patterns? How do one's characteristic “defenses” and coping styles modulate one's responses? This paper describes a novel ambulatory research strategy in which the laboratory is moved into the natural setting. The advantages of this strategy are exemplified in studies of paramedics in whom 24‐hour recordings were made of ambulatory blood pressure and heart rate. The ambulatory physiological data were then related to information about specific work location and subjective ratings of stress made in a diary at the time of each reading, objective assessments of the different stressful situations encountered, and the role of individual differences in anger expression and defensiveness in modulating these relationships. The findings illustrate the ability of real‐life stressors to bring out relationships not typically obtained in the laboratory. Moreover, the natural setting permits individuals to respond to behavioral challenges using their preferred mode of coping with stress, as opposed to the constraints imposed on them in the laboratory. This research strategy has also helped uncover the significance of conflict about the expression of hostility, rather than hostility per se, as a key factor in the “stress response. ”
DO FINANCIAL PERFORMANCE AFFECT THE ENVIRONMENTAL PERFORMANCE AND ENVIRONMENTAL DISCLOSURE? WITH SEM-PLS. CASE: INDONESIAN STOCK EXCHANGE

The company's activities cannot be separated from its impact on the environment. Company activities can have an impact on the environment so that the company is not only faced with profit but also pay attention to the environment in carrying out its activities. However, companies often ignore the environment in their activities. This study aims to provide empirical evidence about the factors that influence the Environmental performance and environmental disclosure in the mining companies that are listed in Indonesian Stock Exchange for the period 2012 to 2016. The variables used are financial performance including liquidity, profitability, and leverage to determine the impact towards environmental performance and environmental disclosure. The method used is the SEM-PLS (Structural Equation Modeling-Partial Least Square) approach with path estimation. The results show that profitability, liquidity, and leverage have a significant effect on environmental performance and also show environmental performance has a significant effect on environmental disclosure. These results are expected to provide additional information about factors that influence environmental performance and environmental disclosure in companies listed in the Indonesia Stock Exchange in the mining sector and provide information for academics research for the development of the capital market.
Two theorems on Galois representations and Shimura varieties

One of the central themes of modern Number Theory is to study properties of Galois and automorphic representations and connections between them. In our dissertation, we describe two different projects that study properties of these objects. In our first project, which is analytic in nature, we consider Artin representations of Q of dimension 3 that are self-dual. We show that these occur with density 0 when counted using the conductor. This provides evidence that self-dual representations should be rare in all dimensions. Our second project, which is more algebraic in nature, is related to automorphic representations. We show the existence of canonical models for certain unitary Shimura varieties. This should help us in computing certain cohomology groups of these varieties, in which regular algebraic automorphic representations having useful properties should be found.
[Grief stages and responses of bereaved mother who lost her children with cancer].

PURPOSE This study was done to develop a bereaved family care program by identifying characteristics of a grief healing process in a child loss. METHOD The subjects were five bereaved mothers who have lost their children with cancer. Data was collected with in-depth interviews using grief phase assessment tool and grief reaction assessment tool from 1, February, 2001 to 31 August, 2002. Data was analyzed on the basis of two tools. RESULT Process of grief in general was as follows: evading phase was within one week - one month, confrontation phase was 5 - 12 months, and reconciliation phase was after 9 months and still going on when the study was finished. Grief reaction in five (physical, cognitive, emotional, social, and spiritual) dimensions was stabilized when the phase moved into reconciliation phase. Influencing factors were intimacy and expectation towards child, social support, personality, prior loss experience, coping style, religion, culture, family cohesion, openness of communication, and stress events. CONCLUSION These results suggest that a bereaved family care program considering characteristics of Korean culture should be developed and activated.
Hematological variables and venous thrombosis : red cell distribution width and blood monocytes are associated with an increased risk Running title : RDW , monocytes and venous thrombosis

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Long-term outcome of early interventions to prevent posttraumatic stress disorder.

BACKGROUND Failing to prevent posttraumatic stress disorder (PTSD) has major clinical and public health consequences. This work evaluates the 3-year outcome of offering early interventions to survivors with acute PTSD. METHODS Adults admitted consecutively to the hospital with acute DSM-IV PTSD were randomized, between June 2003 and October 2007, to 12 weeks of prolonged exposure (n = 63) or cognitive therapy (n = 40) or concealed SSRI (escitalopram; n = 23) versus placebo (n = 23). Eighty-two participants who declined treatment were followed as well. Treatment started 1 month after the traumatic event, and participants were reassessed 5 and 36 months later. Assessors were blinded to treatment allocation and acceptance. The Clinician-Administered PTSD Scale (CAPS) evaluated PTSD and PTSD symptoms. Self-reported symptoms, general functioning, and employment status were secondary outcomes. Participants lost to follow-up were missing completely at random. RESULTS Prolonged exposure and cognitive therapy significantly reduced PTSD and PTSD symptoms between 1 and 5 months (mean CAPS total scores [95% CI] at 1 month: prolonged exposure = 73.59 [68.21-78.96] and cognitive therapy = 71.78 [66.92-78.93]; mean CAPS total scores [95% CI] at 5 months: prolonged exposure = 28.59 [21.89-35.29] and cognitive therapy = 29.48 [21.32-37.95], P < .001), and their results remained stable. At 3 years, however, the study groups had similar levels of PTSD symptoms (mean CAPS total scores [95% CI]: prolonged exposure = 31.51 [20.25-42.78]; cognitive therapy = 32.08 [20.74-43.42]; SSRI = 34.31 [16.54-52.07]; placebo = 32.13 [20.15-44.12]; and no intervention = 30.59 [19.40-41.78]), similar prevalence of PTSD (28.6%-46.2%), and similar secondary outcomes. CONCLUSION Early prolonged exposure and cognitive therapy accelerated the recovery from acute PTSD. Their effect remained stable, however, without reducing the 3-year prevalence of the disorder. The lingering prevalence of PTSD, despite efficient interventions, illustrates a nonremitting, treatment-refractory subset of survivors and outlines a major clinical and public health challenge. TRIAL REGISTRATION ClinicalTrials.gov identifier: NCT00146900.
Small Molecule Therapeutics Synergistic Induction of Apoptosis in Multiple Myeloma Cells by Bortezomib and Hypoxia-Activated Prodrug TH-302 , In Vivo and In Vitro

Recently, we showed that hypoxia is a critical microenvironmental factor in multiple myeloma, and that the hypoxia-activated prodrug TH-302 selectively targets hypoxic multiple myeloma cells and improves multiple disease parameters in vivo. To explore approaches for sensitizing multiple myeloma cells to TH-302, we evaluated in this study the antitumor effect of TH-302 in combination with the clinically used proteasome inhibitor bortezomib. First, we show that TH-302 and bortezomib synergistically induce apoptosis in multiple myeloma cell lines in vitro. Second, we confirm that this synergism is related to the activation of caspase cascades and is mediated by changes of Bcl-2 family proteins. The combination treatment induces enhanced cleavage of caspase-3/8/9 and PARP, and therefore triggers apoptosis and enhances the cleavage of proapoptotic BH3-only protein BAD and BID as well as the antiapoptotic protein Mcl-1. In particular, TH302 can abrogate the accumulation of antiapoptoticMcl-1 inducedbybortezomib, anddecreases the expression of the prosurvival proteins Bcl-2 and Bcl-xL. Furthermore, we found that the induction of the proapoptotic BH3-only proteins PUMA (p53-upregulated modulator of apoptosis) and NOXA is associated with this synergism. In response to the genotoxic and endoplasmic reticulum stresses by TH-302 and bortezomib, the expression of PUMA and NOXA were upregulated in p53-dependent and -independent manners. Finally, in the murine 5T33MMvv model, we showed that the combination of TH-302 and bortezomib can improve multiple disease parameters and significantly prolong the survival of diseasedmice. In conclusion, our studies provide a rationale for clinical evaluation of the combination of TH-302 and bortezomib in patients with multiple myeloma. Mol Cancer Ther; 12(9); 1763–73. 2013 AACR.
Bacterial pneumonia in older people.

We have read the letter from Falon A and O ́Neill D in response to our article “Bacteremic Pneumococcal Pneumonia in Elderly and Very Elderly Patients: Host and Pathogen-related Factors, Process of Care, and Outcome” (1) with interest. The reviewers highlight the importance of oropharyngeal dysphagia (OD) in elderly patients with pneumonia. We totally agree with them regarding the role of OD and subsequent clinical aspiration as both a risk and a prognostic factor for community-acquired pneumonia (CAP) in elderly patients. In relation to their comment, we would like to make the following points. We conducted a prospective observational study including all consecutive patients admitted with bacteramic pneumococcal pneumonia (BPP). We did not include patients with aspiration pneumonia. It is possible that some of our patients could have had silent aspiration. Recently, Almirall and colleagues (2) have published a series of 36 hospitalized elderly patients (aged >70-years old) with CAP. In that well-designed study, silent aspiration was present in 16.7% of patients with pneumonia, in contrast to 0% of healthy elderly control subjects. Patients were not reevaluated after discharge to assess whether this condition had improved after resolution of pneumonia. In the design of our study, we did not include universal screening of subclinical aspiration in these patients, for this reason we cannot confirm the role of silent aspiration in the outcome of our patients with BPP. We also agree with Falon A and O ́Neill D about the routine assessment of OD in all elderly patients with recurrent pneumonia. By contrast, we could have some concerns regarding the routine screening of this disorder in nonfrail elderly patients (3) with a first episode of pneumonia. Probably further studies are needed to assess the impact of silent aspiration on health outcome in these patients, especially in the subgroup of nonfrail patients.
Fiber-type Composition of the Human Jaw Muscles—(Part 1) Origin and Functional Significance of Fiber-type Diversity

This is the first of two articles on the fiber-type composition of the human jaw muscles. The present article discusses the origin of fiber-type composition and its consequences. This discussion is presented in the context of the requirements for functional performance and adaptation that are imposed upon the jaw muscles. The human masticatory system must perform a much larger variety of motor tasks than the average limb or trunk motor system. An important advantage of fiber-type diversity, as observed in the jaw muscles, is that it optimizes the required function while minimizing energy use. The capacity for adaptation is reflected by the large variability in fiber-type composition among muscle groups, individual muscles, and muscle regions. Adaptive changes are related, for example, to the amount of daily activation and/or stretch of fibers. Generally, the number of slow, fatigue-resistant fibers is relatively large in muscles and muscle regions that are subjected to considerable activity and/or stretch.
Endostatin sensitizes p53‐deficient non‐small‐cell lung cancer to genotoxic chemotherapy by targeting DNA‐dependent protein kinase catalytic subunit

Endostatin was discovered as an endogenous angiogenesis inhibitor with broad‐spectrum antitumour activities. Although clinical efficacy was observed when endostatin was combined with standard chemotherapy for non‐small cell lung cancer (NSCLC), as well as other cancer types, the specific mechanisms underlying the benefit of endostatin are not completely understood. Extensive investigations suggest that endostatin is a multifunctional protein possessing more than anti‐angiogenic activity. Here, we found that endostatin exerts a direct chemosensitizing effect on p53‐deficient tumour cells. Concomitant treatment with endostatin and genotoxic drugs resulted in therapeutic synergy in both cellular and animal models of p53‐deficient NSCLC. Mechanistically, endostatin specifically interacts with DNA‐dependent protein kinase catalytic subunit (DNA‐PKcs) in tumour cells and suppresses its DNA repair activity. Using isogenic NSCLC cells with different p53 statuses, we discovered that p53‐deficient tumour cells show chemoresistance to genotoxic drugs, creating a synthetic dependence on DNA‐PKcs‐mediated DNA repair. In this setting, endostatin exerted inhibitory effects on DNA‐PKcs activity, leading to accumulation of DNA lesions and promotion of the therapeutic effect of genotoxic chemotherapy. In contrast, p53‐proficient tumour cells were more sensitive to genotoxic drugs so that DNA‐PKcs could be cleaved by drug‐activated caspase‐3, making DNA‐PKcs inhibition less effective during this ongoing apoptotic process. Therefore, our data demonstrate a novel mechanism for endostatin as a DNA‐PKcs suppressor, and indicate that combination therapy of endostatin with genotoxic drugs could be a promising treatment strategy for cancer patients with p53‐deficient tumours. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Pelvic Fractures in a Pediatric Level I Trauma Center

Objectives Assess the characteristics associated with the risk of complications and mortality in children sustaining pelvic fractures. Setting Urban university pediatric Level I trauma center in a large metropolitan community. Patients/Participants Retrospective analysis of 57 consecutive children with 66 pelvic fractures seen between 1993 and 1999. Intervention Fifty-two patients were treated nonoperatively, and five patients required operative stabilization (four acetabular fractures and one partial sacroiliac joint disruption). Main Outcome Measure Type and cause of pelvic fracture, type of management used, incidence of associated injuries, hemorrhage requiring transfusion, and mortality. Results Hemorrhage directly related to the pelvic fracture occurred in only one patient (2%), whereas 11 other patients required transfusions associated with other body-area injuries. Three patients with pelvic fractures died (5%), but deaths were due to other body-area injuries. Conclusions Children with pediatric pelvic fractures require careful evaluation for other body-area injuries, as these are most likely to be related to hemorrhage or mortality.
An EMD-SARIMA-Based Modeling Approach for Air Traffic Forecasting

The ever-increasing air traffic demand in China has brought huge pressure on the planning and management of, and investment in, air terminals as well as airline companies. In this context, accurate and adequate short-term air traffic forecasting is essential for the operations of those entities. In consideration of such a problem, a hybrid air traffic forecasting model based on empirical mode decomposition (EMD) and seasonal auto regressive integrated moving average (SARIMA) has been proposed in this paper. The model proposed decomposes the original time series into components at first, and models each component with the SARIMA forecasting model, then integrates all the models together to form the final combined forecast result. By using the monthly air cargo and passenger flow data from the years 2006 to 2014 available at the official website of the Civil Aviation Administration of China (CAAC), the effectiveness in forecasting of the model proposed has been demonstrated, and by a horizontal performance comparison between several other widely used forecasting models, the advantage of the proposed model has also been proved.
Comparison between long- and short-axis techniques for ultrasound-guided cannulation of internal jugular vein

Context: Real-time ultrasound guidance for internal jugular (IJ) vein cannulation enhances safety and success. Aims: This study aims to compare the long- and short-axis (LA and SA) approaches for ultrasound-guided IJ vein cannulation. Subjects and Methods: Patients undergoing surgery and in intensive care unit requiring central venous cannulation were randomized to undergo either LA or SA ultrasound-guided cannulation of the IJ vein by a skilled anesthesiologist. First pass success, the number of needle passes, time required for insertion of guidewire, and complications were documented for each procedure. Results: The IJ vein was successfully cannulated in all patients. There are no significant differences between the two groups in terms of gender, diameter of IJ vein, margin of safety, and time required for insertion of guidewire. There was also no significant difference between the two groups in terms of side of IJ vein cannulated, patient on mechanical ventilation, number of skin puncture, number of needle redirections, first pass success, and carotid puncture. However, there is a significant relationship between the diameter of IJ vein with first pass (18.18 ± 4.72 vs. 15.21 ± 4.24; P < 0.004) and margin of safety with of incidence of carotid puncture (12.15 ± 4.03 vs. 6.59 ± 3.13; P < 0.016). Conclusions: Both techniques have similar outcomes when used for IJ vein cannulation.
A new observation of enhanced bias temperature instability in thin gate oxide p-MOSFETs

Bias temperature instability (BTI) and its underlying physical mechanism are studied for thin gate oxide MOSFETs. For p-MOSFETs stressed in inversion for a long-time, BTI increase is observed at high stress temperature. This is shown to be due to higher interface trap generation because of faster hydrogen diffusion in the gate poly. Enhanced BTI affects device lifetime and is strongly influenced by gate oxide scaling, as discussed.
Longitudinal analysis of an HLA-B*51-restricted epitope in integrase reveals immune escape in early HIV-1 infection

Objective:To fully define cytotoxic T-lymphocyte (CTL) escape variants of an HLA-B*51-restricted integrase epitope in early HIV-1 infection. Design:Ninety-four longitudinally sampled acute/early HIV-1 subtype B-infected participants were assessed to determine HLA-B*51-restricted LPPVVAKEI (LI9) escape variants. Methods:LI9 was sequenced at baseline and subsequent time points. Interferon-&ggr; (IFN&ggr;) ELISpot assays were performed using serial log dilutions of variant LI9 peptides to determine the cellular response and functional avidity. Results:There is a significant association between HLA-B*51 expression and an evolving LI9 sequence from baseline to year 1 (P < 0.0001). We detected that the V32I and P30X polymorphisms emerged within HLA-B*51+ participants over time. Reversion of the P30S polymorphism was observed by year 1 in one HLA-B*51− participant. LPPIIAKEI and LPSIVAKEI had significantly lower functional avidity compared with LPPVVAKEI and so may be less well recognized by LI9-specific CTLs; a positive IFN&ggr; response to IPSVVAKEI was rarely seen. Functional avidity to wild-type LI9 inversely correlated with viral load (R2 = 0.448, P = 0.0485). Conclusion:Our results provide support for the role of HLA-B*51-restricted CTLs and functional avidity in the control of early HIV-1 infection.
The two intracellular Ca2+ release channels, ryanodine receptor and inositol 1,4,5-trisphosphate receptor, play different roles during fertilization in ascidians.

Fertilization in the ascidians triggers an activation wave of calcium release followed by intracellular calcium oscillations synchronous with periodic membrane potential excursions during the completion of the meiotic cell cycle. Fertilization also causes a fast decrease in the egg plasma membrane depolarization-activated calcium current and a large increase in capacitance thought to represent membrane addition to the egg surface. We have analyzed the temporal and causal relationships between these changes in the eggs of Phallusia mammillata using whole-cell patch-clamp recording while simultaneously imaging calcium with fura-2 dextran. We have defined the role of ryanodine receptor (RyR) and InsP3 receptor (InsP3R) during fertilization and meiosis by looking at the effects of InsP3, cyclic ADP ribose (cADPR), and ryanodine in perfused oocytes. We show that InsP3 (10 microM perfused through the patch pipette) is able to trigger sustained oscillations in intracellular calcium concentration in unfertilized oocytes, resembling those recorded in fertilized egg completing meiosis. In addition the sustained oscillations resulting from InsP3 perfusion in unfertilized oocytes are sufficient to cause the emission of both polar bodies. In contrast, ryanodine or cADPR never trigger detectable calcium signal in perfused oocytes. Instead, nanomolar concentrations of ryanodine or cADPR cause a capacitance change, implying a net insertion of membrane to the oocyte surface, and trigger a fast decrease in the depolarization-activated calcium current. Both changes are similar to the changes in conductance and capacitance naturally observed following fertilization. These effects, although not associated with measurable calcium signals, are abolished by coperfusion of the calcium chelator BAPTA. In contrast to ryanodine or cADPR, sustained perfusion of the oocyte with nanomolar concentrations of InsP3 causes no capacitance change and a slow and moderate decrease in calcium current. Our observations on inseminated patch-clamped eggs further indicate that membrane insertion, which starts 15-20 sec after the onset of the membrane conductance change at fertilization, can be altered by interfering with the RyR. Our results imply that, in ascidians, as in some mammals, RyR and InsP3R play distinct roles during fertilization.