Miracle-dz/UniFAR-FTUs huggingface dataset:
New endeavors, risk taking, and personal growth in the recovery process: findings from the STARS study.

OBJECTIVE This study examined consumers' perspectives on the role of personal growth-related risk taking in the recovery process and on clinicians' roles in patients' decisions to take on new activities and opportunities. Clinical approaches cited by patients as most helpful in making significant changes were also identified. METHODS A total of 177 members of a nonprofit health plan (93 women and 85 men), ranging in age from 16 to 84 years, participated in a mixed-methods exploratory study of recovery among individuals with serious mental illness (schizophrenia, schizoaffective disorder, bipolar disorder, and affective psychosis). Participants completed four in-depth semistructured interviews over 24 months; interviews were transcribed verbatim and coded for content by study staff. Data were analyzed using a modified grounded theory approach. RESULTS The most helpful discussions about new endeavors occurred in the context of healthy, collaborative, mutually trusting clinician-patient relationships. Advice was accepted when clinicians listened well, knew patients' capabilities and interests, and pushed gently at a pace that was comfortable for patients. Knowledge gained by clinicians in the context of good relationships with patients provided a firm grounding for approaching the delicate balance of providing helpful levels of support and encouragement without pushing consumers so hard that it caused difficulties. CONCLUSIONS Enduring, strong, collaborative relationships provide a healthy framework for discussions between patients and clinicians about taking on new activities, roles, or responsibilities and increase the likelihood that new activities and opportunities will be planned and carried out in ways that promote, rather than endanger, recovery.
H magnetic resonance spectroscopy in the investigation of intractable epilepsy

We have been using proton magnetic resonance spectroscopy (1H MRS) in the investigation of adults and children with intractable epilepsy. Spectra were obtained from 2 × 2 times 2 cm cubes in the medial region of the temporal lobe, and were analyzed on the basis of signals from N‐acetylaspartate (NAA), creatine+phosphocreatine (Cr), and choline‐containing compounds (Cho). In comparison with control subjects, the epilepsy patients as a group show significant reductions in the NAA signal and in the NAA/Cho + Cr ratio, with increases in the Cho and Cr signals. The reduction in NAA is interpreted in terms of neuronal loss or damage, while the increase in Cr and Cho signals may be a reflection of reactive astrocytosis.
Crowd medical services in the English Football League: remodelling the team for the 21st century using a realist approach

Objectives To evaluate the new model of providing care based on demand. This included reconfiguration of the workforce to manage workforce supply challenges and meet demand without compromising the quality of care. Design Currently the Sports Ground Safety Authority recommends the provision of crowd medical cover at English Football League stadia. The guidance on provision of services has focused on extreme circumstances such as the Hillsborough disaster in 1989, while the majority of demand on present-day services is from patients with minor injuries, exacerbations of injuries and pre-existing conditions. A new model of care was introduced in the 2009/2010 season to better meet demand. A realist approach was taken. Data on each episode of care were collected over 14 consecutive football league seasons at Millwall FC divided into two periods, preimplementation of changes and postimplementation of changes. Data on workforce retention and volunteer satisfaction were also collected. Setting The data were obtained from one professional football league team (Millwall FC) located in London, UK. Primary and secondary outcomes The primary outcome was to examine the demand for crowd medical services. The secondary outcome was to remodel the service to meet these demands. Results In total, 981 episodes of care were recorded over the evaluation period of 14 years. The groups presenting, demographic and type of presentation did not change over the evaluation. First aiders were involved in 87.7% of episodes of care, nurses in 44.4% and doctors 17.8%. There was a downward trend in referrals to hospital. Workforce feedback was positive. Conclusions The new workforce model has met increased service demands while reducing the number of referrals to acute care. It involves the first aid workforce in more complex care and key decision-making and provides a flexible registered healthcare professional team to optimise the skill mix of the team.
Rifampin in the treatment of experimental brucellosis in mice and guinea pigs.

Rifampin, a broad-spectrum antibiotic able to penetrate intracellularly, was used for treatment of infections with Brucella melitensis in mice and Brucella abortus in guinea pigs. Treatments were administered for seven, 14, or 21 days; mice were given 25 mg of rifampin/kg per day, and guinea pigs 100 mg/kg per day. Efficacy of the drug was determined by comparison of rifampin-treated animals with saline-treated controls and with tetracycline-treated mice (200 mg/kg per day) according to the following criteria: (1) primary infections of the spleen and (in guinea pigs) of the lymph nodes; (2) residual infections of the spleen, i.e., infections shown after complementary treatment with suspensions of killed Corynebacterium parvum or with cortisone; (3) splenomegaly; and (4) serological response (in guinea pigs). Treatment with rifampin, even for one or two weeks, drastically reduced the number of infections by all of these criteris, and treatment for three weeks cured nearly all mice; the incidences of primary and residual infections in rifampin-treated mice after three weeks were 0 and 8.5%, respectively, as compared with 70.3% and 73.5%, respectively, in tetracycline-treated mice. Of 25 guinea pigs treated with rifampin for three weeks, spleen infection was shown in one, and lymph node infections in 10.
Speaker Diarization Using Convolutional Neural Network for Statistics Accumulation Refinement

The aim of this paper is to investigate the benefit of information from a speaker change detection system based on Convolutional Neural Network (CNN) when applied to the process of accumulation of statistics for an i-vector generation. The investigation is carried out on the problem of diarization. In our system, the output of the CNN is a probability value of a speaker change in a conversation for a given time segment. According to this probability, we cut the conversation into short segments that are then represented by the i-vector (to describe a speaker in it). We propose a technique to utilize the information from the CNN for the weighting of the acoustic data in a segment to refine the statistics accumulation process. This technique enables us to represent the speaker better in the final i-vector. The experiments on the English part of the CallHome corpus show that our proposed refinement of the statistics accumulation is beneficial with the relative improvement of Diarization Error Rate almost by 16 % when compared to the speaker diarization system without statistics refinement.
Ursolic acid plays a role in Nepeta sibthorpii Bentham CNS depressing effects

The sedative, anticonvulsant and analgesic activity of ursolic acid, a terpenoid bioassay‐isolated from Nepeta sibthorpii Bentham, was evaluated in mice. The oral administration of ursolic acid (2.3 mg/kg) produced a significant depressant effect on CNS by reducing spontaneous motor activity and the number and lethality of pentylenetetrazol (PTZ)‐induced seizures. Two models of nociception, the writhing test and the hot plate test, were also used to examine the analgesic effect of ursolic acid. At a dose of 2.3 mg/kg, ursolic acid caused an inhibition of acetic acid‐induced abdominal constriction, but was inactive in the hot plate test. Treatment at a higher dose (20 mg/kg) significantly increased the reaction time in the hot plate test. This effect, reversed by naloxone, evidently involves opioid receptors, but the analgesic activity of ursolic acid may be related also to the antiinflammatory and antioxidant properties of this compound. Copyright © 2007 John Wiley & Sons, Ltd.
[Frequency as the cardinal determinant for electroacupuncture analgesia to be reversed by opioid antagonists].

Antagonism of the analgesic effect of electroacupuncture (EA) by opioid anta-gonist naloxone has been regarded as strong evidence for the participation ofendogenous opioids in EA analgesia. We found in the present study that subcu-taneous injection of opioid antagonist naloxone or naltrexone, 1 mg/kg, was capableof reversing low and medium frequency (2, 15Hz) EA analgesia, but not highfrequency (100 Hz) EA effect which could only be partially blocked by 20 mg/kgof naloxone. From the dose-response curve obtained by 0. 25-20 mg/kg of naloxonethe doses needed for 50% reversal of 2, 15 and 100 Hz fixed frequency EA analgesiawere calculated to be 0.53, 1.02 and 24 mg/kg respectively. When a changingfrequency (2-15 Hz, 12 cycles per minute) was used, the analgesic effect couldonly be partially blocked by a large dose of naloxone (100μg intracerebroventri-cularly, or 20 mg/kg subcutaneously). Under either of the afore-mentioned fre-quencies, changes in the intensity of EA stimulation (1, 2, 3V) exhibited little effecton naloxone reversibility of EA effect. The results indicate that the frequency of EA stimulation seems to be thecardinal factor in determining the degree of reversal of EA analgesia by naloxoneand that different kinds of endogenous opioids might have been released in thecentral nervous system by EA stimulation of different frequencies.
Tax Base Elasticities: A Multi-State Analysis of Long-Run and Short-Run Dynamics

We examine the relative dynamic responses of state personal tax revenues and sales tax bases to changes in state personal income. Our econometric analysis, which includes separate analyses of long-run and short-run dynamics for each state, permits the estimation of asymmetric short-run responses depending upon the relationship between current and expected tax base growth. Results indicate that the average long-run elasticity for income taxes is more than double that for sales taxes. Most states have asymmetric short-run income elasticities, which are again greater for income taxes than for sales taxes. However, a joint analysis of long- and short-run dynamics reveals that neither tax is universally more volatile. After calculating state-specific income elasticities for both taxes, we employ cross-section regression techniques to explain the variation in elasticities across states. Several policy factors are found to be important, including elements of tax bases and rate structures.
Cognitive and mood effects of phenobarbital treatment in people with epilepsy in rural China: a prospective study

Background Phenobarbital is an effective treatment for epilepsy but concerns remain over its potential neurocognitive toxicity. This prospective study evaluated the effects of phenobarbital treatment on cognition and mood in people with epilepsy in rural China. Methods We recruited 144 adults with convulsive seizures and 144 healthy controls from six sites in rural China. People with epilepsy were treated with phenobarbital monotherapy for 12 months. At baseline, and at 3, 6 and 12 months, cases and controls were evaluated with a battery of neuropsychological tests: the Mini-Mental State Examination, the Hamilton Depression Rating Scale, a digit span test, a verbal fluency test, an auditory verbal learning test and a digit cancellation test. Efficacy of phenobarbital treatment was evaluated at the end of follow-up for those with epilepsy. Results Cognitive test scores and mood ratings were available for 136 (94%) people with epilepsy and 137 (95%) controls at the 12 month follow-up. Both groups showed slightly improved performance on a number of neuropsychological measures. The people with epilepsy showed greater performance gains (p=0.012) in verbal fluency. Nine people with epilepsy complained of memory problems during the treatment period. Conclusion In this study, phenobarbital was not found to have a major negative impact on cognitive function of people with convulsive seizures and some cognitive gains were observed, possibly due to improved seizure control.
Masticatory Muscles Activity Associated with Occlusal Factors : An EMG Review

The aim of the study was to conduct a review of electromyographic studies, in order to assess the relationship between various occlusal features and masticatory muscles' activity. An exhaustive MEDLINE computer search was performed to identify all experimental studies present in the English literature describing the relationship between the electromyographyc evaluation of patients and their occlusal morphology. The search methodology provided a total of 102 abstracts and from these 11 full reports were selected as full text. Of the 11 articles selected, 8 studied the variation of the muscular activity as a consequence of the experimental introduction of occlusal disturbances whereas the remaining three studies estimated the electrical muscular characteristics without any artificial alteration of the occlusal morphology. The results obtained seem to suggest that occlusal features can affect the electrical signals recordings of masticatory muscles. Further researches are strongly requested to realize if this altered muscular activity can turns in the occurrence of TMDs.
Detection and Evaluation of Gastric Motility for Erosive Gastritis Patients

In order to investigate the complex course of electricity and mechanism of erosive gastritis (EG), including its rhythm, transmission, gastric empty course and the influences of them, it is neccesery to extract gastric motility feature indexes. Methods: According the clinic standardization, 30 volunteers of erosive gastritis were selected. The signal processing device was designed by Chongqing University of Posts and Telecommunications. Both signals impedance gastric motility (IGM) and EGG collected from body surface are decomposed by multi-resolution analysis (MRA). Wavelet transform is addressed to separate the IGM signal from breathing and blood flowing impedance signals. By the means of energy and freqency spectrum analysis technic, the signals can be classify according to the dominant power and dominant frequency. Some indexes such as frequency of EGG and IGM, signal power spectrum and dynamic spectrum, the rates of rhythm and power for the normal EGG and IGM and so on can also be calculated. Results: The experiments of gastric motility measurement and evaluation are executed including before teating and after a week. The parameters have changed significantly between health adult and patient (P 0.05). The results of the experiments show that the method based on the synchronous measurement of EGG and IGM can provide a non-invasive way to investigate and evaluate gastric motility situation corresponding gastrointestinal physiology and pathology conditions.
Aortovenous Fistulas Due to Ruptured Infrarenal Aortic Aneurysms: Experience With Six Cases

A review of patients undergoing aortic aneurysmectomy between 1970 and 1979 at the Emory University Hospital and the Atlanta Veterans Administration Medical Center disclosed six patients with aortovenous fistulas. Four fistulas were aorta to vena cava; one, aorta to left renal vein; and one, aorta to left iliac vein. Four of the arteriovenous fistulas were identified preoperatively. In another patient the symptoms and signs were masked by concomitant retroperitoneal rupture of the aneurysm. The final patient was asymptomatic preoperatively, but had an occluded fistula discovered at operation when laminated thrombus was removed from the wall of the aneurysm. One patient died while being prepared for operation; five were operated upon and survived. Successful management of this problem is contingent upon preoperative recognition, careful manipulation of the aneurysm with endoaneurysmal closure of the fistula, and judicious perioperative fluid management.
Ultrasonic imaging of internal vibration of soft tissue under forced vibration

An imaging system that can display both the amplitude and phase maps of internal vibration in soft tissues for forced low-frequency vibration is described. In this method, low-frequency sinusoidal vibration of frequency under several hundred hertz is applied from the surface of the sample and the resulting movement in it is measured from the Doppler frequency shift of the simultaneously transmitted probe ultrasonic waves. Basic experiments are carried out by using 3.0-MHz ultrasonic waves. The two-dimensional maps of the amplitude and phase of internal vibration are shown, and the velocities of vibration are measured for some samples as well as in vivo. <<ETX>>
Use of restriction fragment polymorphism analysis of rRNA genes to assign species to unknown clinical isolates of oral viridans streptococci

This study evaluated restriction fragment length polymorphisms of rRNA genes (ribotyping) for genotypic identification of 53 oral isolates classified as "Streptococcus sanguis" by colony morphology. Isolates were from 8-h buccal plaque on lower first permanent molars of 20 subjects. DNA was digested with AatII and hybridized with digoxygenin-labeled cDNA of Escherichia coli 16S and 23S rRNA. Strains were ribotyped again with AlwNI or PvuII on the basis of the presence or absence of a 2,290-bp AatII band. Band patterns were compared with reference ribotypes for Streptococcus gordonii, Streptococcus sanguis, Streptococcus crista, Streptococcus oralis, Streptococcus mitis, and Streptococcus parasanguis strains. Forty-eight isolates could be assigned to a species (22 S. sanguis, 14 S. oralis, 12 S. gordonii). Multiple species were seen in 14 subjects; multiple strains of the same species occurred in 11 subjects. Our findings suggest that ribotyping can be used for genotypic identification of S. sanguis, S. oralis, and S. gordonii isolates.
Applying EEG-based vigilance measurement in a case of adult attention deficit hyperactivity disorder.

Adult attention-deficit hyperactivity disorder (ADHD) is characterized by inattentiveness, hyperactivity, mood lability, hot- or short-temper, impaired stress tolerance, disorganization and impulsivity (Wender, 1995). Due to the reduction of externalizing symptoms in adulthood and the absence of hyperactivity in the predominantly inattentive subtype, ADHD is more difficult to diagnose in adults (Nierenberg et al., 2005) and often unrecognized or mistakenly attributed to other psychiatric conditions (Kessler et al., 2006). Adult ADHD overlaps in symptom profiles and is highly co-morbid with other psychiatric disorders, including major depressive disorder (MDD), bipolar disorder (BD) and substance abuse, making the discrimination of symptoms more complicated (Wilens et al., 2009) and warranting the search for facilitating diagnostic tools.
Community Corrections Officers' Attributions for Sexual Offending Against Children

ABSTRACT The present research examined gender differences in community corrections officers' (CCOs') attributions for child sexual offending. Eighty-five CCOs were asked to write down the reasons why they thought men sexually abused children, and then rate their reasons using Benson's Attributional Dimensions Scale. The results found that CCOs' reasons regarding why men sexually abuse children strongly paralleled current scientific theories on the etiology of child sexual abuse. Also, significant gender differences were found regarding the frequency with which participants cited certain types of reasons for child sexual abuse. Female CCOs were more likely to cite power and control as a reason, while male CCOs were more likely to cite psychopathology as a reason for child sexual abuse. No other gender differences were found. The research, clinical, and educational implications pertaining to these findings are discussed.
Isolation and identification of melanin-concentrating hormone as the endogenous ligand of the SLC-1 receptor.

Melanin-concentrating hormone (MCH), which is an orexigenic peptide, was isolated and identified as the endogenous ligand of the SLC-1 receptor. We established a CHO cell line expressing the rat SLC-1 receptor to search for its endogenous ligand. The extract of rat whole brain showed inhibition of intracellular forskolin-induced cAMP accumulation in rat SLC-1-expressing CHO cells and was purified. Using HPLC purification, we isolated and identified MCH as the endogenous ligand of the SLC-1 receptor. The authentic MCH demonstrated a dose-dependent inhibitory effect on cAMP accumulation in forskolin-stimulated rat and human SLC-1-expressing CHO cells with an EC(50) value of 0.2 nM for both the rat and human SLC-1 receptors. This is the first description of the functional receptor for MCH.
Sclerosing angiomatoid nodular transformation of the spleen (SANT): Clinicopathological study of 10 cases with or without abdominal disseminated calcifying fibrous tumors, and the presence of a significant number of IgG4+ plasma cells

Sclerosing angiomatoid nodular transformation (SANT) is a peculiar splenic vascular lesion that is characterized by marked stromal sclerosis and the presence of plasma cells, which shares histopathological features associated with IgG4‐related sclerosing disease. The cinicopathological features of 10 cases of SANT were reviewed and immunohistochemistry with IgG4 and IgG antibodies was performed. Nine other various splenic lesions served as controls. Five cases of SANT were found incidentally. Three cases of SANT had multiple tumors and five had associated abdominal disseminated calcifying fibrous tumors (CFT). IgG4+ plasma cells were found in all of the cases of SANT and in calcifying fibrous tumors. The densities of IgG4+ and IgG+ cells and the IgG4/IgG ratios were significantly higher in SANT than in control spleens (P= 0.001, 0.006, and 0.028, respectively). Serum IgG4 concentration was elevated in one case. In conclusion, SANT can occur either as a solitary or as multiple tumors. Frequent association with abdominal disseminated CFT simulating carcinomatosis was observed. A statistically significant number of IgG4+ plasma cells was found in all of the cases of SANT and the associated CFT. Whether they are related to the IgG4‐related sclerosing disease or not is debatable and warrants further investigation.
First Detected Human Case in Algeria of mcr-1 Plasmid-Mediated Colistin Resistance in a 2011 Escherichia coli Isolate

The mcr-1 gene, a transferable plasmid-mediated colistin resistance gene, was recently detected in Escherichia coli isolates from animals, food, and patients in China ([1][1]). This gene spread rapidly beyond China into southern Asia, Europe, South America, and Africa, mirroring the emerging NDM-1-