Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of Olaparib for Maintenance Monotherapy on Survival in Breast and Ovarian Cancer: A Systematic Review and Pooled Analysis of Published Trials

Purpose: To assess the efficacy and safety of Olaparib, a PARP inhibitor on progression-free survival (PFS), objective response rate (ORR) and overall survival (OS) in patients with breast and ovarian cancer. Methods: Research data from clinical trials through PubMed, Science Citation Index, Elsevier Science Direct and Cochrane Library of all published studies exploring the PFS, ORR or OS of Olaparib for maintenance monotherapy on survival in breast and ovarian cancer were analysed. Pooled estimates of the ORR, weighted medians of PFS and OS from all Olaparib were calculated. Assessment of quality and level of evidence was assigned by Cochrane guidelines and guidelines of Oxford Centre for Evidence-Based Medicine. Results: Data of 893 patients (731 olaparib; 162 control) from 6 trials, 2 randomised controlled trials and 4 non-randomised trials, were included. The overall median weighted PFS and OS in patients treated with Olaparib were 5.9 and 19.1 months, respectively. The pooled ORR was 25%. Olaparib showed a greater effect on PFS in patients with both wild-type BRCA and BRCA mutant gene. The most common toxicity were nausea and vomiting. Conclusions: Olaparib as maintenance monotherapy for breast and ovarian cancer is associated with promising outcomes including increased response rate and improved PFS. Its potential in clinical application is needed for further investigation in phase III trials.
Use of a pilin gene probe to study molecular epidemiology of Pseudomonas aeruginosa

Strains of Pseudomonas aeruginosa from patients with cystic fibrosis (CF) are unusual. The majority have a rough lipopolysaccharide (LPS) which renders them nontypeable by conventional typing systems based on a serological reaction with the O polysaccharide of smooth LPS. We developed a new typing scheme using a pilin gene probe as a marker for hybridization with endonuclease-digested genomic DNA from P. aeruginosa. Twenty-one different restriction fragment length polymorphism (RFLP) types were found among 249 isolates. RFLP type 7 was recovered only from patients with thermal burns (9 of 14 isolates) in both Vancouver, British Columbia, and Edmonton, Alberta, Canada. None of the other RFLP types showed a clear predilection for disease state or environmental niche. Multiple morphologically different isolates from individual patients with CF were studied; each isolate in 33 of 40 sputum samples had an identical RFLP type, despite considerable LPS serotype heterogeneity. Sequential isolates from 23 patients were studied; in 10 isolates there was a clear change in both the RFLP and the LPS serotype. We conclude that patients with CF usually harbor a single P. aeruginosa RFLP type in their sputa, but that one strain can replace another as the predominant colonizing type.
A growing literature on bargaining and reputation focuses particularly on a specific tactic – standing firm and not backing down from the initial offer – and analyze its impacts on bilateral negotiations ( Myerson 1991

It is common to think of reputation as assets –things of value that require costly investments to build, that can deteriorate if not maintained attentively. This paper shows that under reputational concerns, the equilibrium outcome of a highly competitive market may not be Walrasian. In particular, the incentive of committing to a specific share, the opportunity of building reputation about inflexibility and the anxiety to preserve their reputation can provide significant market power to the players that are in the long side of the market, even when frictions are negligible. ∗This research was supported by the Marie Curie International Reintegration Grant (# 256486) within the European Community Framework Programme. I would like to thank David Pearce, Wolfgang Pesendorfer, Larry Samuelson, Mehmet Ekmekçi, Ennio Stacchetti, Kalyan Chatterjee, Vijay Krishna, Ariel Rubinstein, Alessandro Lizzeri and Tomasz Sadzik for helpful comments and suggestions. I also thank seminar participants at Caltech, Penn State, the Econometric Society World Congress 2010 in Shanghai, the 2 Brazilian Workshop of the Game Theory Society 2010 in Brazil, TOBB, METU, the Midwest Theory Conference 2010 in Evanston, Econometric Society Meeting 2009 in Boston, ASSET 2009, SWET 2009, Carnegie Mellon (Tepper Business School), New York University, Maastricht, LUISS Guido Carli, Koc, Sabanci, Bogazici and Bilkent. All the remaining errors are my own. †Faculty of Arts and Social Sciences, Sabancı University, 34956, Istanbul, Turkey. (e-mail: ozyurt@sabanciuniv.edu)
Seizures in the Neonatal Intensive Care Unit of the 1980s

A retrospective review was taken of 150 newborns with seizures evaluated at the same medical center and by the same investigator(s) from 1982 to 1987. The aims of the study were to determine in this current population the distribution of clinical seizure types, the distribution of causative etiologies, and the relation of etiology to the timing of onset of the seizures. Seizures were classified as subtle, multifocal clonic, generalized tonic, focal clonic, and myoclonic. Subtle (65% of total) and multifocal clonic seizures (54% of total) were the most common seizure types. Subtle seizures usually occurred in combination with other seizure types. Only one seizure type was related to gestational age, i.e., focal clonic seizures in the term infant. Hypoxic-ischemic encephalopathy (65% of total) was by far the most common etiology in both preterm and term infants. Seizures with hypoxic-ischemic encephalopathy occurred characteristically early in the neonatal period, i.e., 90 percent in the first 2 days of life. Moreover, 80 percent of all seizures in the first 2 days of life were related to hypoxic-ischemic encephalopathy.
Model-driven development of simulation solution based on SysML starting with the simulation core

Today's market is filled with a variety of simulation solutions for discrete-event simulation, but each one has its own meta-model. A conversion between these meta-models is complicated or even impossible. In some cases this is intended by the vendor of the simulation solution, in other cases it is because of missing standards during development time. We propose SysML as a standardized simulation language and to support this we develop a simulation solution with SysML as meta-model. For that purpose model-driven methods are used for decreased development time and increased stability and maintainability compared to traditional development techniques. In this paper we present the design of the simulation core, and how model-driven techniques can be used for the development of a discrete-event simulation solution. We are starting with SysML as the meta-model, followed by an execution engine based on fUML and create a SysML based simulation core. Additionally we will give a brief introduction to the Eclipse Modeling Framework (EMF), the Java Emitter Templates (JET) and eJava, a tool developed by the Software Technology Group at the Dresden University of Technology.
Modular Modelling of an Embedded Mobile CPU-GPU Chip for Feature Estimation

This paper deals with the modelling of a CPU-GPUchip embedded in an Android phone. The model is used for the estimation of variables that characterise the operating state of System on Chip (SoC). The proposed model is built to demonstrate the causal relationships between the variables, through its interconnected structure of subsystems. This structure allows the extension of other components or the easy exchange of subsystems in the case of a change in components or operating mode. The model developed here requires no additional instrumentation—other than the one present on the phone—which facilitates its implementation. It is used for the estimation of the state of the system and can also be used for monitoring and behaviour prediction. The model is validated and the results are promising for further implementation.
Patterns and correlates of local therapy for women with ductal carcinoma-in-situ.

PURPOSE Concerns have been raised about the quality of treatment for women with ductal carcinoma-in-situ (DCIS) because persistent high rates of mastectomy suggest overtreatment, whereas lower than expected rates of radiation therapy after breast-conserving surgery (BCS) suggest undertreatment. PATIENTS AND METHODS All women with DCIS diagnosed in 2002 and who reported to the Detroit and Los Angeles Surveillance, Epidemiology, and End Results (SEER) registries were identified and surveyed shortly after receipt of surgery (response rate, 79.7%; n = 817). Analyses were restricted to patients with DCIS (n = 659) indicated by SEER stage data. RESULTS Only 14.0% of patients at lowest risk of recurrence (based on tumor size and histologic grade) received a mastectomy compared with 22.8% and 52.6% of patients at intermediate and highest risk (P < .001). Only 13.1% of patients who were not influenced or slightly influenced by concerns about recurrence received mastectomy compared with 48.8% of women who were greatly influenced by this concern (P < .001). A between-geographic site difference in receipt of radiation after BCS was observed for the lowest risk group (38.9% in Los Angeles v 70.5% in Detroit) but not for the highest risk group (80.2% in Los Angeles v 85.9% in Detroit, P = .006 for site and risk group differences). Between-site differences in receipt of radiation after BCS were consistent with patient recall of surgeon discussions about treatment. CONCLUSION Surgeons are tailoring their recommendations for local therapy options for DCIS based on important clinical factors. Patient attitudes also play an important role in treatment decisions. The substantial influence of both surgeon opinion and patient attitudes should temper concerns about the quality of treatment for women with DCIS.
Comparison of IVA and GIG-ICA in Brain Functional Network Estimation Using fMRI Data

Spatial group independent component analysis (GICA) methods decompose multiple-subject functional magnetic resonance imaging (fMRI) data into a linear mixture of spatially independent components (ICs), some of which are subsequently characterized as brain functional networks. Group information guided independent component analysis (GIG-ICA) as a variant of GICA has been proposed to improve the accuracy of the subject-specific ICs estimation by optimizing their independence. Independent vector analysis (IVA) is another method which optimizes the independence among each subject's components and the dependence among corresponding components of different subjects. Both methods are promising in neuroimaging study and showed a better performance than the traditional GICA. However, the difference between IVA and GIG-ICA has not been well studied. A detailed comparison between them is demanded to provide guidance for functional network analyses. In this work, we employed multiple simulations to evaluate the performances of the two approaches in estimating subject-specific components and time courses under conditions of different data quality and quantity, varied number of sources generated and inaccurate number of components used in computation, as well as the presence of spatially subject-unique sources. We also compared the two methods using healthy subjects' test-retest resting-state fMRI data in terms of spatial functional networks and functional network connectivity (FNC). Results from simulations support that GIG-ICA showed better recovery accuracy of both components and time courses than IVA for those subject-common sources, and IVA outperformed GIG-ICA in component and time course estimation for the subject-unique sources. Results from real fMRI data suggest that GIG-ICA resulted in more reliable spatial functional networks and yielded higher and more robust modularity property of FNC, compared to IVA. Taken together, GIG-ICA is appropriate for estimating networks which are consistent across subjects, while IVA is able to estimate networks with great inter-subject variability or subject-unique property.
Long-term implant survival and success: a 10-16-year follow-up of non-submerged dental implants.

OBJECTIVES The aim of the present study was to evaluate the long-term results of dental implants using implant survival and implant success as outcome variables. METHODS Of the 76 patients who received 162 implants of the Straumann Dental Implant System during the years 1990-1997, 55 patients with 131 implants were recalled 10-16 years after implant placement for a complete clinical and radiographic examination, followed by a questionnaire that examined the degree of satisfaction. The incidence of biological and technical complications has been carefully analysed for each implant. Success was defined as being free of all these complications over the entire observation period. Associated factors related to peri-implant lesions were analysed for each implant. RESULTS The long-term implant cumulative survival rate up to 16 years was 82.94%. The prevalence of biological complications was 16.94% and the prevalence of technical complications was 31.09%. The cumulative complication rate after an observation period of 10-16 years was 48.03%, which meant that substantial amounts of chair time were necessary following implant placement. The majority of implant losses and biological complications were concentrated in a relatively small number of patients. CONCLUSION Despite a relatively high long-term survival rate, biological and technical complications were frequent. Patients with a history of periodontitis may have lower implant survival rates than patients without a history of periodontitis and were more prone to biological complications such as peri-implant mucositis and peri-implantitis.
Comprehensive analysis on SCM specifications for high-performance SCM/NAND flash hybrid SSD with through-silicon via

By adding SCM to NAND flash-based SSD, SCM/NAND flash hybrid SSDs have been proposed for performance improvement. This paper analyzes effects of SCM specifications such as read/write latency, capacity and I/O frequency on performance of the hybrid SSD with through-silicon via (TSV). From the evaluation results, TSV reduces energy consumption by 38% when the SCM capacity is 1% of the NAND flash capacity. In addition, the hybrid SSD achieves 2.1-times Input/Output per Second (IOPS) performance improvement compared with NAND flash-only SSD. The power consumption dependency of the SCM read/write latency and I/O frequency is also analyzed. Only SCM capacity affects the power consumption reduction by TSV. When the SCM capacity is 1% in the hybrid SSD, TSV reduces power consumption by up to 38%. In contrast to the result of power consumption, SCM capacity, read/write latency, and I/O frequency have a large effect on the IOPS performance. Up to 81-times IOPS performance is achieved when SCM capacity, latency, and I/O frequency are 10%, 100 ns, 4266 MHz, respectively.
Anthropometric characteristics of elite cricket fast bowlers

Abstract The aims of this study were to describe the current anthropometric profiles of elite Australian female and male cricket fast bowlers and establish a set of reference values useful for future investigations on player selection, talent identification, and training programme development. The participants were 26 female (mean age 22.5 years, s = 4.5; height 1.71 m, s = 0.05; body mass 66.2 kg, s = 7.5) and 26 male (mean age 23.9 years, s = 3.5; height 1.88 m, s = 0.05; body mass 87.9 kg, s = 8.2) fast bowlers. The anthropometric profiles included the measurement of skinfolds, and segment lengths, breadths, and girths. A series of derived variables assessing the distribution of subcutaneous adipose tissue, the bivariate overlap zone, relative body size and proportionality, and somatotype were also calculated. The male bowlers had larger length, breadth, and girth measurements than their female counterparts. There were differences in proportionality between the sexes, with only the male bowlers exhibiting characteristics that could be considered “large” relative to height. The female bowlers had a higher sum of seven skinfolds (P < 0.001), were more endomorphic (F 1,50 = 30.18, P < 0.001), and less mesomorphic (F 1,50 = 10.85, P < 0.01) than the male bowlers. These reference data should be useful to practitioners and researchers interested in cricket. Further research is needed to clarify why only male fast bowlers had variables that were proportionally large relative to height.
The Porcine Endosalpinx at Different Reproductive Stages . Morphology , Immune Cell Infiltration and Cytokine Expression

Fertilization takes place in the lower part of the porcine oviduct and to be successful, a balance between immunological tolerance to allogeneic differences and immune reactivity to foreign pathogens is required. The thesis aims to describe immune cells and morphological changes in different segments [isthmus (Isth), ampulla (Amp) and infundibulum (Inf)] of the porcine oviduct at various stages of the oestrous cycle, after artificial insemination (AI, preand post-ovulatory) and during early pregnancy. The expression of pro-inflammatory and suppressive cytokines was also determined (RT-PCR and immunohistochemistry, IHC) in oviductal samples collected after AI with different components (fresh semen, spermatozoa in extender or extender alone) or only catheter inserted (control) in gilts. In cyclic sows, the epithelial morphology of Amp and Inf varied during the oestrous cycle. High levels of pseudostratification, mitotic activity and secretory granules were found at pro-oestrus/oestrus indicating influence of ovarian hormones. Lymphocytes were predominant in the epithelium whereas both lymphocytes and plasma cells were the major cell types in the connective tissue (CNT). Higher numbers of these cells were found in the Inf than in the Isth both in the cyclic sows and in sows after AI. Neutrophils were found mainly in the infundibular CNT, in cyclic sows at pro-oestrus and in pre-ovulatory inseminated sows in one group (40h after AI). In post-ovulatory inseminated sows, the numbers of neutrophils were lower but present for a longer period. In gilts, IHC-labelling for TGF-β1, IL-10 and IL-6 was apparent, especially in the epithelial cells. Higher mRNA expressions of these cytokines were found in the Isth compared with the Inf and the TGF-β1 mRNA expression was higher than that of IL-6 and IL-10 in both segments. Shortly after AI, no difference between treatments could be detected for any of these cytokines but 35-40 h after AI, the TGF-β1 mRNA expressions were higher in gilts inseminated with different semen components than in the control animals (only catheter inserted). Thus, endogenous production of TGF-β1, IL-10 and IL-6 was indicated and suggests that these cytokines have a physiological function in the porcine oviduct. The relatively higher expression of TGF-β1 mRNA indicates that this cytokine exerts an immunomodulatory role, mainly in the isthmic part of the oviduct, and this seems to be enhanced by AI. The differences between the upper and lower part of the porcine oviduct regarding presence of immune cells and expression of cytokines are likely to reflect a local immune modulation.
Characterization of the Self-Cleaving Effector Protein NopE1 of Bradyrhizobium japonicum

ABSTRACT NopE1 is a type III-secreted protein of the symbiont Bradyrhizobium japonicum which is expressed in nodules. In vitro it exhibits self-cleavage in a duplicated domain of unknown function (DUF1521) but only in the presence of calcium. Here we show that either domain is self-sufficient for cleavage. An exchange of the aspartic acid residue at the cleavage site with asparagine prevented cleavage; however, cleavage was still observed with glutamic acid at the same position, indicating that a negative charge at the cleavage site is sufficient. Close to each cleavage site, an EF-hand-like motif is present. A replacement of one of the conserved aspartic acid residues with alanine prevented cleavage at the neighboring site. Except for EDTA, none of several protease inhibitors blocked cleavage, suggesting that a known protease-like mechanism is not involved in the reaction. In line with this, the reaction takes place within a broad pH and temperature range. Interestingly, magnesium, manganese, and several other divalent cations did not induce cleavage, indicating a highly specific calcium-binding site. Based on results obtained by blue-native gel electrophoresis, it is likely that the uncleaved protein forms a dimer and that the fragments of the cleaved protein oligomerize. A database search reveals that the DUF1521 domain is present in proteins encoded by Burkholderia phytofirmans PsNJ (a plant growth-promoting betaproteobacterium) and Vibrio coralliilyticus ATCC BAA450 (a pathogenic gammaproteobacterium). Obviously, this domain is more widespread in proteobacteria, and it might contribute to the interaction with hosts.
Laparoscopic Heller's cardiomyotomy: a viable treatment option for sigmoid oesophagus.

OBJECTIVES It is generally believed that Heller's cardiomyotomy (HCM) cannot improve dysphagia in patients with marked dilatation and axis deviation or sigmoid oesophagus. Conventional management for sigmoid oesophagus has been oesophagectomy. We report our surgical experience in the management of 8 patients with sigmoid oesophagus with laparoscopic HCM. METHODS Eight patients with sigmoid oesophagus were retrospectively identified and their records were reviewed for symptomatic outcome evaluation following laparoscopic HCM with an antireflux procedure. Preoperative and postoperative, oesophageal and respiratory symptoms and quality of life scoring of achalasia were recorded. RESULTS The mean age was 35.5 (range 25-57) years. Males and females were equally distributed. All patients had dysphagia as their chief presenting complaint. The median duration of dysphagia was 55 (range 18-180) months. All the patients had a poor quality of life. Four patients also had chronic cough. All 8 patients underwent laparoscopic HCM with an antireflux procedure. The mean duration of operation was 203.7 min. There were no mortalities and no major postoperative complications. At a median follow-up of 19.5 (range 6-45) months, there was a significant improvement of dysphagia and regurgitation scores with P-values of 0.014 and 0.008, respectively. Quality of life also significantly (P = 0.005) improved post-surgery. Chronic cough resolved in all the 4 patients (100%) following cardiomyotomy. CONCLUSIONS Laparoscopic HCM with an antireflux procedure provides significant symptom relief in patients with sigmoid oesophagus and may be considered as the first-line treatment option in such patients. Oesophagectomy should be reserved for patients with a failed cardiomyotomy.