Miracle-dz/UniFAR-FTUs huggingface dataset:
SCIENTIFIC BASES OF QUANTUM-HOLOGRAPHIC PARADIGM

—Quantum bases of consciousness and free will are considered with implications of two cognitive modes of consciousness (direct religious/creative, in quantum-coherent transitional and altered states of individual consciousness, and indirect perceptually/rationally mediated, in classically-reduced normal states of individual consciousness). Implications for local and global psychosomatics, and religious and transpersonal phenomena, are considered too. Conditions for observation of quantum-coherent quantum-holographic implicate order and classically-reduced explicate order are also discussed.
FOURIER-TYPE KERNELS AND TRANSFORMS ON THE REAL LINE

Kernels of integral transforms of the form k(xy) are called Fourier kernels. Hardy and Titchmarsh [6] and Watson [15] studied self-reciprocal transforms with Fourier kernels on the positive half-real line R+ and obtained nice characterizing conditions and other properties. Nevertheless, the Fourier transform has an inherent complex, unitary structure and by treating it on the whole real line more interesting properties can be explored. In this paper, we characterize all unitary integral transforms on L(R) with Fourier kernels. Characterizing conditions are obtained through a natural splitting of the kernel on R+ and R−, and the conversion to convolution integrals. A collection of concrete examples are obtained, which also include ”discrete” transforms (that are not integral transforms). Furthermore, we explore algebraic structures for operator-composing integral kernels and identify a certain Abelian group associated with one of such operations. Fractional powers can also be assigned a new interpretation and obtained.
Identification of new octamer transcription factor 1‐target genes upregulated in castration‐resistant prostate cancer

Octamer transcription factor 1 (OCT1) is an androgen receptor (AR)‐interacting partner and regulates the expression of target genes in prostate cancer cells. However, the function of OCT1 in castration‐resistant prostate cancer (CRPC) is not fully understood. In the present study, we used 22Rv1 cells as AR‐positive CRPC model cells to analyze the role of OCT1 in CRPC. We showed that OCT1 knockdown suppressed cell proliferation and migration of 22Rv1 cells. Using microarray analysis, we identified four AR and OCT1‐target genes, disks large‐associated protein 5 (DLGAP5), kinesin family member 15 (KIF15), non‐SMC condensin I complex subunit G (NCAPG), and NDC80 kinetochore complex component (NUF2) in 22Rv1 cells. We observed that knockdown of DLGAP5 and NUF2 suppresses growth and migration of 22Rv1 cells. Furthermore, immunohistochemical analysis showed that positive expression of DLGAP5 in prostate cancer specimens is related to poor cancer‐specific survival rates of patients. Notably, enhanced expression of DLGAP5 was observed in CRPC tissues of patients. Thus, our findings suggest that these four genes regulated by the AR/OCT1 complex could have an important role in CRPC progression.
The Effects of Attitudinal, Normative, and Control Beliefs on M-Learning Adoption Among the Students of Higher Education in Pakistan

This study intends to analyze the influence of behavioral and psychosocial factors of higher education students of Karachi on acceptance of m-learning as a mode of getting education. The Theory of Planned Behavior and Technology Acceptance Model have provided the basic frameworks to formulate the hypotheses for this study. The analyses of the study reveal that attitudinal beliefs and subjective norms have significant and positive impact on m-learning. Additionally, control influences on Perceived Behavioral Control also make significant contributions in the adoption of m-learning methodologies. Collectively, all of these factors converge to form greater intent of the students to assimilate this new learning environment. It was also found that the characteristics and features of the mobile gadgets such as greater familiarity of the students with them, handiness and ease of use, influences them to utilize these devices in completing their academic tasks, hence, influencing their intention toward the adoption of m-learning. Also seamless learning experience, students get through m-learning, reduces their mental resistance toward it and encourages them to adopt it. Information pertaining to the defined criteria was gathered through a specimen of 300 questionnaire responses and was then analyzed using the reliability analysis, confirmatory factor analysis, and partial least square-structural equation modeling to assess the influence of these factors on m-learning adoption.
Association between Sociodemographic Factors and Dietary Patterns in Children Under 24 Months of Age: A Systematic Review

Background: Understanding early-life complementary feeding dietary patterns and their determining factors could lead to better ways of improving nutrition in early childhood. The purpose of this review was to evaluate evidence of the association between sociodemographic factors and dietary patterns (DPs) in children under 24 months. Methods: Medline (PubMed), Cochrane Central, NICE guidelines, and Trip database were searched for observational studies that evaluated sociodemographic factors and their associations with DP. Results: Seven studies were selected for the present review. High education level among mothers was inversely associated with unhealthy DPs and positively associated with healthy DPs. Higher household income was negatively associated with unhealthy DPs. Four studies showed a positive association between low household income and unhealthy DPs and three studies showed a positive association between higher household income and healthy DPs. Additionally, in younger mothers, body mass index (BMI ≥ 30.0 kg/m2) and number of children were positively associated with unhealthy DPs. Conclusions: This review provides evidence of a positive association between mothers’ higher education level, higher household income, higher maternal age, and healthy dietary patterns as well as a negative association between these factors and unhealthy dietary patterns. Further studies from low- and middle-income countries are needed for comparison with associations showed in this review.
Socioeconomic inequalities in suicide mortality in Barcelona during the economic crisis (2006–2016): a time trend study

Objectives This study aimed to analyse trends in socioeconomic inequalities in suicide mortality in Barcelona before and after the start of the economic crisis that started at the end of 2008, including both individual factors and contextual factors of the deceased’s neighbourhood of residence. Design This is a trend study of three time periods: pre-economic crisis (2006–2008), early crisis (2009–2012) and late crisis (2013–2016). Setting Total Barcelona residents between 2006 and 2016 (≥25 years of age) and death data derived from the Judicial Mortality Registry of Barcelona. Participants 996 deaths by suicide between 2006 and 2016 were analysed. Primary and secondary outcome measures The outcomes were age-standardised suicide mortality rates and the associations (relative and absolute risk) between suicide mortality and individual and contextual characteristics for the three time periods. Results From 2006 to 2008, men with a lower educational level were more likely to commit suicide than better educated men (relative risk (RR)=1.46; 95% CI 1.11 to 1.91). This difference disappeared after the onset of the crisis. We found no differences among women. From 2013 to 2016, suicide risk increased among men living in neighbourhoods with higher unemployment levels (RR=1.57; 95% CI 1.09 to 2.25) and among women living in neighbourhoods with a higher proportion of elderly people living alone (RR=2.13; 95% CI 1.15 to 3.93). Conclusions We observed risks for suicide among men living in neighbourhoods of Barcelona with higher unemployment levels and among women living in neighbourhoods with a higher proportion of elderly people living alone. Inequalities in suicide mortality according to educational level tended to disappear during the crisis among men. Thus, it is important to continue to monitor suicide determinants especially in times of economic crisis.
Robust Forecast Superiority Testing with an Application to Assessing Pools of Expert Forecasters

We develop a forecast superiority testing methodology which is robust to the choice of loss function. Following Jin, Corradi and Swanson (JCS: 2017), we rely on a mapping between generic loss forecast evaluation and stochastic dominance principles. However, unlike JCS tests, which are not uniformly valid, and have correct asymptotic size only under the least favorable case, our tests are uniformly asymptotically valid and non-conservative. These properties are derived by first establishing uniform convergence (over error support) of HAC variance estimators and of their bootstrap counterparts, and by extending the asymptotic validity of generalized moment selection tests to the case of non-vanishing recursive parameter estimation error. Monte Carlo experiments indicate good finite sample performance of the new tests, and an empirical illustration suggests that prior forecast accuracy matters in the Survey of Professional Forecasters. Namely, for our longest forecast horizons (4 quarters ahead), selecting pools of expert forecasters based on prior accuracy results in ensemble forecasts that are superior to those based on forming simple averages and medians from the entire panel of experts.
Corruption a Bane to Development in Nigeria

There is a mixed opinion in the economics literature on whether corruption promotes economic development or not. The complexity of corruption in terms of its definition and measurement has also deterred many studies to be carried out in terms of its effect on economic development. In order to have a good clarification, the study investigates the extent at which corruption affects development in Nigeria between 1982 and 2015 using cointegration and ECM methods of analysis to determine the long and short run effects of the variables. The findings from the study suggest that there is a long-run relationship among the variables (economic development (ED) and corruption) while the ECM explains that the previous year disequilibrium is adjusted back in this current year at 88.67% speed of adjustment. Overall, it is concluded that corruption has significant negative effect on economic development in Nigeria thereby slows down development in the country. The study therefore recommended among others, the need to strengthen anti-corruption agencies and also give them autonomy so as to enable them discharge their duties effectively.
Depressive role impairment and subthreshold depression in older black and white women: race differences in the clinical significance criterion

ABSTRACT Objectives: We examined race differences in the DSM-IV clinical significance criterion (CSC), an indicator of depressive role impairment, and its impact on assessment outcomes in older white and black women with diagnosed and subthreshold depression. Design: We conducted a secondary analysis of a community-based interview study, using group comparisons and logistic regression. Setting: Lower-income neighborhoods in a Midwestern city. Participants: 411 community-dwelling depressed and non-depressed women ≥ 65 years (45.3% Black; mean age = 75.2, SD = 7.2) recruited through census tract-based telephone screening. Measurements: SCID interview for DSM-IV to assess major depression and dysthymia; Center for Epidemiologic Studies-Depression Scale to define subthreshold depression (≥16 points); Mini-Mental State Examination, count of medical conditions, activities of daily living, and mental health treatment to assess health factors. Results: Black participants were less likely than Whites to endorse the CSC (11.8% vs. 24.1%; p = .002). There were few race differences in depressive symptom type, severity, or count. Blacks with subthreshold depression endorsed more symptoms, though this comparison was not significant after adjustments. Health factors did not account for race differences in CSC endorsement. Disregarding the CSC-eliminated differences in diagnosis rate, race was a significant predictor of CSC endorsement in a logistic regression. Conclusions: Race differences in CSC endorsement are not due to depressive symptom presentations or health factors. The use of the CSC may lead to underdiagnosis of depression among black older adults. Subthreshold depression among Blacks may be more severe compared to Whites, thus requiring tailored assessment and treatment approaches.
Lack of Group Support and Burnout Syndrome in Workers of the State Security Forces and Corps: Moderating Role of Neuroticism

Background and Objectives: This research analyzes the relationship between the lack of group support and burnout syndrome in workers of the State Security Forces and Corps, considering the role of personality traits in this relationship. In particular, it is hypothesized that neuroticism will moderate this relationship. Materials and Methods: Participants were 237 workers from the State Security Forces and Corps dedicated to tasks of citizen security. Results: The results show that neuroticism moderates the relationship between lack of group support and the three components of the burnout syndrome: emotional exhaustion, depersonalization, and personal fulfillment. Conclusions: The findings are discussed, suggesting intervention strategies for the improvement of the agents’ personal well-being.
Multimodal MRI characterization of visual word recognition: an integrative view

The ventral occipito-temporal (vOT) association cortex contributes significantly to recognize different types of visual patterns. It is widely accepted that a subset of this circuitry, including the visual word form area (VWFA), becomes trained to perform the task of rapidly identifying word forms. An important open question is the computational role of this circuitry: To what extent is part of a bottom-up hierarchical processing of information on visual word recognition and/or is involved in processing top-down signals from higher-level language regions. This doctoral dissertation thesis proposal is aimed at characterizing the vOT reading circuitry using behavioral, functional, structural and quantitative MRI indexes, and linking its computations to the other two important regions within the language network: the posterior parietal cortex (pPC) and the inferior frontal gyrus (IFG). Results revealed that two distinct word-responsive areas can be segregated in the vOT: one responsible for visual feature extraction that is connected to the intraparietal sulcus via the vertical occipital fasciculus and a second one responsible for semantic processing that is connected to the angular gyrus via the posterior arcuate fasciculus and to the IFG via the anterior arcuate fasciculus. Importantly, reading behavior was predicted by functional activation in regions identified along the vOT, pPC and IFG, as well as by structural properties of the white matter fiber tracts linking them. The present work constitutes a critical step in the creation of a highly detailed characterization of the early stages of reading at the individual-subject level and to establish a baseline model and parameter range that might serve to clarify functional and structural differences between typical, poor and atypical readers.
Kin recognition and co‐operative foraging in Drosophila melanogaster larvae

A long‐standing goal for biologists and social scientists is to understand the factors that lead to the evolution and maintenance of co‐operative behaviour between conspecifics. To that end, the fruit fly, Drosophila melanogaster, is becoming an increasingly popular model species to study sociality; however, most of the research to date has focused on adult behaviours. In this study, we set out to examine group‐feeding behaviour by larvae and to determine whether the degree of relatedness between individuals mediates the expression co‐operation. In a series of assays, we manipulated the average degree of relatedness in groups of third‐instar larvae that were faced with resource scarcity, and measured the size, frequency and composition of feeding clusters, as well as the fitness benefits associated with co‐operation. Our results suggest that larval D. melanogaster are capable of kin recognition (something that has not been previously described in this species), as clusters were more numerous, larger and involved more larvae, when more closely related kin were present in the social environment. These findings are discussed in the context of the correlated fitness‐associated benefits of co‐operation, the potential mechanisms by which individuals may recognize kin, and how that kinship may play an important role in facilitating the manifestation of this co‐operative behaviour.
On- or Off-pump Coronary Artery Bypass Surgery. Is the Debate Settling Down?

The long-standing controversy on the merits and shortcomings of coronary artery bypass surgery (CABG) being performed onand off-pump has been addressed by a recent series of robust evidences shedding light on prevailing disputed issues. Long-term follow-ups from randomized trials using these two techniques are reassuring on the quality and safety of off-pump coronary artery bypass (OPCAB), therefore, bringing back a valuable tool for the coronary surgeon armamentarium.
Immunogenicity Associated with Botulinum Toxin Treatment

Botulinum toxin (BoNT) has been used for the treatment of a variety of neurologic, medical and cosmetic conditions. Two serotypes, type A (BoNT-A) and type B (BoNT-B), are currently in clinical use. While considered safe and effective, their use has been rarely complicated by the development of antibodies that reduce or negate their therapeutic effect. The presence of antibodies has been attributed to shorter dosing intervals (and booster injections), higher doses per injection cycle, and higher amounts of antigenic protein. Other factors contributing to the immunogenicity of BoNT include properties of each serotype, such as formulation, manufacturing, and storage of the toxin. Some newer formulations with purified core neurotoxin devoid of accessory proteins may have lower overall immunogenicity. Several assays are available for the detection of antibodies, including both structural assays such as ELISA and mouse-based bioassays, but there is no consistent correlation between these antibodies and clinical response. Prevention and treatment of antibody-associated non-responsiveness is challenging and primarily involves the use of less immunogenic formulations of BoNT, waiting for the spontaneous disappearance of the neutralizing antibody, and switching to an immunologically alternate type of BoNT.
Pulmonary Fibrosis in Children

Pulmonary fibrosis (PF) is a very rare condition in children, which may be observed in specific forms of interstitial lung disease. None of the clinical, radiological, or histological descriptions used for PF diagnosis in adult patients, especially in situations of idiopathic PF, can apply to pediatric situations. This observation supports the view that PF expression may differ with age and, most likely, may cover distinct entities. The present review aims at summarizing the current understanding of PF pathophysiology in children and identifying suitable diagnostic criteria.
Discovery of Novel Angiotensin-Converting Enzyme Inhibitory Peptides from Todarodes pacificus and Their Inhibitory Mechanism: In Silico and In Vitro Studies

In order to rapidly and efficiently excavate antihypertensive ingredients in Todarodes pacificus, its myosin heavy chain was hydrolyzed in silico and the angiotensin-converting enzyme (ACE) inhibitory peptides were predicted using integrated bioinformatics tools. The results showed the degree of hydrolysis (DH) theoretically achieved 56.8% when digested with papain, ficin, and prolyl endopeptidase (PREP), producing 126 ACE inhibitory peptides. By predicting the toxicity, allergenicity, gastrointestinal stability, and intestinal epithelial permeability, 30 peptides were finally screened, of which 21 had been reported and 9 were new. Moreover, the newly discovered peptides were synthesized to evaluate their in vitro ACE inhibition, showing Ile-Ile-Tyr and Asn-Pro-Pro-Lys had strong effects with a pIC50 of 4.58 and 4.41, respectively. Further, their interaction mechanisms and bonding configurations with ACE were explored by molecular simulation. The preferred conformation of Ile-Ile-Tyr and Asn-Pro-Pro-Lys located in ACE were successfully predicted using the appropriate docking parameters. The molecular dynamics (MD) result indicated that they bound tightly to the active site of ACE by means of coordination with Zn(II) and hydrogen bonding and hydrophobic interaction with the residues in the pockets of S1 and S2, resulting in stable complexes. In summary, this work proposed a strategy for screening and identifying antihypertensive peptides from Todarodes pacificus.
Replication Studies ( and How to Anyways ) Position Paper

Reproducibility has been increasingly encouraged by communities of science in order to validate experimental conclusions, and replication studies represent a significant opportunity to vision scientists wishing contribute new perceptual models, methods, or insights to the visualization community. Unfortunately, the notion of replication of previous studies does not lend itself to how we communicate research findings. Simple put, studies that re-conduct and confirm earlier results do not hold any novelty, a key element to the modern research publication system. Nevertheless, savvy researchers have discovered ways to produce replication studies by embedding them into other sufficiently novel studies. In this position paper, we define three methods—re-evaluation, expansion, and specialization—for embedding a replication study into a novel published work. Within this context, we provide a non-exhaustive case study on replications of Cleveland and McGill’s seminal work on graphical perception. As it turns out, numerous replication studies have been carried out based on that work, which have both confirmed prior findings and shined new light on our understanding of human perception. Finally, we discuss how publishing a true replication study should be avoided, while providing suggestions for how vision scientists and others can still use replication studies as a vehicle to producing visualization research publications.