Miracle-dz/UniFAR-FTUs huggingface dataset:
Revisión bibliométrica de la producción científica en balonmano A bibliometric review of the scientific production in handball Revisão bibliométrica da produção científica no handebol

The aim of the present study was to provide a bibliometric review of the scientific production in handball. Publications were collected from the Web of Science and MEDLINE databases for the period 1900-2012 and 1950-2012 respectively. The analysis assessed the document types and languages, annual trend of published articles, average number of authors per article, research disciplines and topics, trend of publication in research disciplines, major journals, author productivity, and country distribution of publications. Only the papers focused mainly on handball were consid- ered, for a total of 373 articles under study. There was a significant increase in number of published articles and average number of authors per article in recent years, which allows considering handball an expanding research field both in terms of scientific production and research collaboration. Sports medicine was the most active research discipline, the studies focused on injuries the main topic. In the last two decades there was a remarkable annual growth in the disciplines of sport training theory, anthropometry and biomechanics. European authors participated in 87.94% of the articles, Norwegians the most active, revealing Europe's big dominance in handball research. This study provides baseline information on future research direc - tions for researchers and academic institutions interested in handball.
Gender Segregation among College and University Employees

This article examines the gender composition and degree of job segregation among current and recently hired employees in U.S. four-year colleges and universities. Aggregate-level patterns of women's representation by job category are discussed, and a contextual analysis identifies the level of gender segregation according to organizational conditions and institutional characteristics. The results indicate that the gender composition of an institution's employees is more balanced and men and women are less segregated into different jobs when institutions have a relatively high proportion of women students and women administrators, less emphasis on research, more reliance on federal revenue sources, and smaller endowed sources of revenue. Geographic factors seem to have stronger influences on the gender composition of nonprofessional than of faculty positions. Implications for models of discriminatory processes and for the status of women workers in colleges and universities are discussed.
Severe Disability in a Patient With Rheumatoid Arthritis and Sickle Cell Anemia: An Underreported, But Yet a Potentially Treatable Combination of Diseases.

To the Editor: T he coexistence of rheumatoid arthritis (RA) and sickle cell anemia (SCA) has been little reported in the literature. We describe such a case and discuss the importance of recognizing the coexisting diseases, the role of musculoskeletal (MSK) imaging, and a coordinated multidisciplinary team (MDT) approach to treatment. A 20-year-old Nigerian woman with known SCA was admitted with acute
Impact of Personality on Task Selection in Crowdsourcing Software Development: A Sorting Approach

Growing demand for software has attracted the attention of the software development industry. Crowdsourced software development has provided a new method for the software industry to produce quality software based on an open-call format. Selecting an appropriate task to develop (developer-end) or evaluate (platform-end) is one of the primary problems in this type of open-call format. Receiving or assigning an improper task to an improper crowdsource (CS) developer does not only decrease the quality of the software deliverables, but also causes overburden on both the platform and the developers. To solve this problem, sorting the tasks based on the developers’ human characteristics may increase task relevancy for developers, which can accelerate efficiency and lessen complexity. Thus, this paper has conducted an empirical experiment to measure the influence of personality on task selection based on the important characteristics of a task: money, time, and type. A total of 83 students from the University of Sindh voluntarily participated in four different short-duration rounds of task development using the developed CS platform. The personality types of the participants were measured based on the Myers-Briggs type indicator. In addition, a complex network technique called weighted degree centrality was applied to identify the most suitable personality for task sorting based on money or complexity attractions (i.e., time or type). Based on the results, it can be observed that personality has a significant relationship with task selection. For instance, developers with intuitive (N) and feeling (F) personality traits are primarily focused on the time duration of a project.
A corona-stabilised plasma closing switch

Corona-stabilised plasma closing switches, filled with electronegative gases such as SF6 and air, have been used in pulsed-power applications as repetitive switching devices for the last 10 years. Their high repetition-rate capabilities coupled with their relatively simple design and construction have made them suitable alternatives to thyratrons and semi-conductor switches. As well as having repetitive switching capabilities, corona-stabilised plasma closing switches have the potential to operate at elevated voltages through the incorporation of multiple electrode sets. This allows high-voltage operation with inherent voltage grading between the electrodes. A further feature of such switches is that they can have relatively low jitter under triggered condition. This paper reports on some of the operational features of a new design of corona-stabilised, cascade switch that utilises air as the insulating gas. At pressures between 0 and 1 bar gauge the switch has be shown to operate over the voltage range of 40 to 100 kV with a jitter below 2 ns.
Alternative Donor Graft Sources for Adults with Hematologic Malignancies: A Donor for All Patients in 2017!

Hematopoietic stem cell transplant (HSCT) is potentially curative for a wide variety of malignant diseases, including acute and leukemias, lymphoma, and myelodysplasia. Choice of a stem cell donor is dependent on donor availability, donor compatibility and health, recipient disease type, and recipient condition. Current sources of stem cell donation for HSCT are matched sibling donors (MSDs), matched unrelated donors (MUDs), 1-antigen mismatched unrelated donors (MMUDs), haploidentical donors (haplo), and umbilical cord blood (UCB) units. Historically, preferred donors for HSCT have been human leukocyte antigen (HLA)-matched sibling donors; however, only about 30% of U.S. patients will have a MSD available. The majority of patients referred for HSCT will require an alternative donor graft: MUD, MMUD, UCB, or haplo. The likelihood of finding a MUD varies depending on the ethnicity of the recipient. White Caucasians of European descent have the greatest chance of finding a MUD. Chances of finding a MUD are significantly less for African-American or Hispanic recipients due to HLA polymorphisms. Therefore, MMUD, UCB, and haplo donor graft sources expand the donor pool for recipients who do not have a MSD or MUD available. Given the variety of different donor stem cell sources available today, nearly every patient who needs an allogeneic HSCT has a potential donor in 2017. All transplant-eligible patients with hematologic malignancies should be evaluated by a transplant center to determine if HSCT is a viable treatment option for their underlying disease process. IMPLICATIONS FOR PRACTICE The goal of this review is to increase the awareness of oncology practitioners to the availability of alternative donor stem cell transplants for patients with hematologic malignancies. Despite new agents, stem cell transplant remains the only curative therapy for many patients with acute and chronic leukemia, myelodysplasia, and lymphoma. Given the variety of different donor stem cell sources available today, nearly every patient who needs an allogeneic stem cell transplant will have a donor.
A Rapid Method for Measurement of the Susceptibility to Oxidation of Low-Density Lipoprotein

Oxidation of low-density lipoprotein (LDL) may be important in the pathogenesis of atherosclerosis. We describe a method which measures the oxidation resistance of LDL isolated by a rapid procedure without added antioxidants. LDL was isolated from heparinized plasma by density gradient ultracentrifugation and desalted by gel filtration. The protein concentration was standardized to 50 mg/L and oxidation was promoted by copper (2 μmol/L) at 37°C. The total sample preparation time was 2·5 h. Conjugated diene production was monitored at λ = 234 nm with computation of the lag time. LDL oxidation was inhibited by EDTA but not heparin. Albumin inhibited LDL oxidation but only in concentrations greater than 50 mg/L. LDL was stable in frozen plasma (–70°C) for 10 weeks, but unstable in the isolated and desalted state. The lag time for LDL from patients treated with the antioxidant probucol was markedly prolonged compared to normal subjects.
SERUM SELENIUM AND THE RISK OF PROSTATE CANCER

Introduction: The purpose of this study is to investigate the relationship of serum selenium levels and the risk of developing prostate cancer. It has been documented that antioxidants reduce the incidence of cancer by eradicating free radicals that damage DNA, thus increasing the risk of cancer. Selenium is a component of the antioxidant enzyme glutathione peroxidase, whose role in cancer prevention has been controversial in the last 40 years. Methodology: A systematic review of evidence-based literature was performed utilizing the following search engines: MEDLINE FirstSearch, ArticleFirst, dissertations, and Paper's First and a bibliographic search of selected articles. MeSH ( medical subject heading terms) and text words utilized in this study include: serum, selenium, prostate, neoplasia, risk, nutrition, adenocarcinoma, male, prostatic intraepithelial neoplasm, and prostatic neoplasia. Results: The results of the evidence-based literature results are consistent with the epidemiologic studies available at this time. The best quality evidence suggests that higher selenium levels decrease a man's risk of developing prostate cancer. However, because of unaccounted for confounders including family history of prostate cancer and educational level, it is not recommended that providers prescribe selenium as preventive medicine combating prostate cancer. Nevertheless, individuals who have a higher intake of selenium may benefit from its protective effects.
Acute Ethanol Increases IGF‐I‐Induced Phosphorylation of ERKs by Enhancing Recruitment of p52‐Shc to the Grb2/Shc Complex

Ethanol plays a detrimental role in the development of the brain. Multiple studies have shown that ethanol inhibits insulin‐like growth factor I receptor (IGF‐IR) function. Because the IGF‐IR contributes to brain development by supporting neural growth, survival, and differentiation, we sought to determine the molecular mechanism(s) involved in ethanol's effects on this membrane‐associated tyrosine kinase. Using multiple neuronal cell types, we performed Western blot, immunoprecipitation, and GST‐pulldowns following acute (1–24 h) or chronic (3 weeks) treatment with ethanol. Surprisingly, exposure of multiple neuronal cell types to acute (up to 24 h) ethanol (50 mM) enhanced IGF‐I‐induced phosphorylation of extracellular regulated kinases (ERKs), without affecting IGF‐IR tyrosine phosphorylation itself, or Akt phosphorylation. This acute increase in ERKs phosphorylation was followed by the expected inhibition of the IGF‐IR signaling following 3‐week ethanol exposure. We then expressed a GFP‐tagged IGF‐IR construct in PC12 cells and used them to perform fluorescence recovery after photobleaching (FRAP) analysis. Using these fluorescently labeled cells, we determined that 50 mM ethanol decreased the half‐time of the IGF‐IR‐associated FRAP, which implied that cell membrane‐associated signaling events could be affected. Indeed, co‐immunoprecipitation and GST‐pulldown studies demonstrated that the acute ethanol exposure increased the recruitment of p52‐Shc to the Grb2‐Shc complex, which is known to engage the Ras‐Raf‐ERKs pathway following IGF‐1 stimulation. These experiments indicate that even a short and low‐dose exposure to ethanol may dysregulate function of the receptor, which plays a critical role in brain development. J. Cell. Physiol. 232: 1275–1286, 2017. © 2016 Wiley Periodicals, Inc.
Quality of life and building design in residential and nursing homes for older people

Older people living in residential and nursing care homes spend a large proportion of their time within the boundaries of the home, and may depend on the environment to compensate for their physical or cognitive frailties. Regulations and guidelines on the design of care buildings have accumulated over time with little knowledge of their impact on the quality of life of building users. The Design in Caring Environments Study (DICE) collected cross-sectional data on building design and quality of life in 38 care homes in and near Sheffield, Yorkshire. Quality of life was assessed using methods which included all residents regardless of their frailty, and staff morale was also assessed. The physical environment was measured on 11 user-related domains using a new tool, the Sheffield Care Environment Assessment Matrix (SCEAM). Significant positive associations were found between several aspects of the built environment and the residents' quality of life. There was evidence that a focus on safety and health requirements could be creating risk-averse environments which act against quality of life, particularly for the least frail residents. Staff morale was associated with attributes of a non-institutional environment for residents rather than with the facilities provided for the staff. The new tool for assessing building design has potential applications in further research and for care providers.
What size were Arctodus simus and Ursus spelaeus (Carnivora: Ursidae)?

Body masses of the giant short-faced bear (Arctodus simus Cope) and the cave bear (Ursus spelaeus Rosenmuller & Heinroth) were calculated with equations based on a long-bone dimensions:body mass proportion ratio in extant carnivores. Despite its more long-limbed, gracile and felid-like anatomy as compared with large extant ursids, large Arctodus specimens considerably exceeded even the largest extant ursids in mass. Large males weighed around 700–800 kg, and on rare occasions may have approached, or even exceeded one tonne. Ursus spelaeus is comparable in size to the largest extant ursids; large males weighed 400–500 kg, females 225–250 kg. Suggestions that large cave bears could reach weights of one tonne are not supported.
Aerosol deposition in cystic fibrosis using an aerosol conservation device and a conventional jet nebulizer

Abstract The deposition of technetium radiolabelled aerosol within the lungs of 12 stable cystic fibrosis patients (mean age 12.7 years) was compared using the Acorn nebulizer and mouthpiece alone, and the Acorn nebulizer attached to the Mizer Aerosol Conservation Device (MACD). The total activity delivered to the patient using the MACD was 11.1% (\pm7.8% s.d.) of the initial dose, compared to 5.8% (\pm4.2% s.d.) with the nebulizer and mouthpiece alone (P<0.05). With the MACD, 84% of the intrapulmonary dose was delivered to the peripheral regions, compared to 76.5% with the nebulizer and mouthpiece (P<0.05). No significant correlation was found between aerosol deposition and pulmonary function. The Mizer Aerosol Conservation Device significantly increases both total intrapulmonary aerosol deposition and peripheral aerosol distribution.
Signal transduction inhibitors and antiangiogenic therapies for malignant glioma

Detailed characterization of the cancer genome in a large number of primary human glioblastomas has identified recurrent alterations that result in deregulation of signal transduction pathways and are “druggable” with a growing number of small molecule pharmaceuticals. While many of these compounds have shown clinical activity in other human cancers harboring similar genetic alterations, the clinical experience in glioblastoma has been disappointing thus far with only rare and transient radiographic responses. Our understanding of drug resistance is confounded by the uncertainty of drug delivery across the blood brain barrier and the limited knowledge to what extent the growth of these tumors depends on any particular signaling pathway. This uncertainty is, at least in part, due to shortcomings in the current approach to evaluate signal transduction inhibitors in glioma patients, including drug testing in molecularly unselected patient populations, limited documentation of drug penetration and target inhibition in tumor tissue, and use of radiographic response criteria that may not be optimal for the evaluation of these compounds. © 2011 Wiley‐Liss, Inc.
Cerebrospinal Fluid Concentrations of Functionally Important Amino Acids and Metabolic Compounds in Patients with Mild Cognitive Impairment and Alzheimer’s Disease

Cerebrospinal fluid (CSF) biomarkers play an important role in the differential diagnosis of neurodegenerative diseases such as Alzheimer’s disease (AD) and its postulated precursor stage mild cognitive impairment (MCI). While CSF tau protein, phospho-tau protein and β-amyloid have become part of the diagnostic process in clinical routine, the importance of several other biomarkers remains quite unclear. Among these, amino acids and metabolic compounds have been studied in clinical conditions mostly other than AD and, to our knowledge, never in MCI. In patients with AD (n = 14) and MCI (n = 13) we now determined CSF levels of 36 different amino acids and metabolic compounds by high-performance liquid chromatography. We found that 8 out of 36 amino acids (urea, threonine, glutamate, citrulline, α-aminobutyric acid, ornithine, ammonia and arginine) were significantly elevated in the CSF of patients with AD compared to those with MCI. As most of these amino acids and metabolic compounds are functionally important for brain-specific metabolic processes, neurotransmitter pathways or compensatory mechanisms, our findings might reflect these changes occurring within the brain of patients with MCI and those who developed manifest AD.
Hypertension after heart and heart/lung transplantation in childhood – Study on the evolution of short‐term blood pressure regulation

Kohler SM, Reisner J, Kozlik‐Feldmann R, Januszewska K, Netz H, Pozza RD. Hypertension after heart and heart/lung transplantation in childhood – Study on the evolution of short‐term blood pressure regulation. Pediatr Transplantation 2011: 15: 804–808. © 2011 John Wiley & Sons A/S.
[Correlation between orthostatic hypotension and cardiovascular risks in elderly population].

OBJECTIVE To investigate the correlation between orthostatic hypotension and cardiovascular risks and hospitalization rate in the elders. METHODS A total of 1174 people over 65 years old underwent health screening physical examination through a self-made questionnaire at our hospital. Their clinical data were collected. The orthostatic blood pressure and heart rate were measured in supine position after resting for over 5 minutes and at 0 and 2 min after standing. Orthostatic hypotension was defined as 20 mm Hg or greater decrease in SBP or/and 10 mm Hg or greater decrease in DBP after standing. All cases were followed up by telephone or hospitalization medical records for a mean period of 315.8 days. The primary endpoint was the occurrence of such cardiovascular or cerebrovascular events as angina, fatal or nonfatal myocardial infarction (MI), congestive heart failure, sudden cardiac death, ischemic and hemorrhagic stroke. RESULTS The prevalence of OH was 25.6% in this cohort. Significant differences could be found in the rate of all-cause and cardiovascular-related hospitalization between OH positive and OH negative (45.1% vs 32.5%; 19.1% vs 7.4%); the rates of angina and myocardial infarction in the OH positive group were significantly higher than those in the OH negative group (7.5% vs 3.7%: 4.8% vs 0.5%, P < 0.05); after adjusting for age, supine blood pressure, heart rate and cerebrovascular history by logistic regression, statistical differences could also be observed between OH and angina [P = 0.011, HR (hazard ratio): 2.122, 95%CI (confidence interval): 1.184-3.802 and MI (P < 0.001, HR: 8.995, 95%CI: 2.909 - 27.819)]. CONCLUSION Orthostatic hypotension may increase the rates of all-cause and cardiovasular-related hospitalization. And it is a robust predictor of angina and myocardial infarction in the elders.
A Raloxifene Withdrawal Response

Creative Commons CC-BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). Editorial
Factor VIII in Von Willebrand's Disease

The hemostatic problems encountered in von Willebrand's disease (VWD) appear to be corrected by factor VIII, one of the essential constituents of the blood coagulation system. Similarly, the bleeding problems encountered in classic hemophilia also are corrected by factor VIII. The clinical and laboratory observations suggest that these two diseases are very different, yet the genesis of both appears to result from absent or non-functional factor VIII. Our under standing of factor VIII and its relationship to VWD and classic hemophilia is an area of exciting research
Sharing “happy” information

This study focuses on the sharing of “happy” information: information that creates a sense of happiness within the individual sharing the information. We explore the range of factors motivating and impacting individuals' happy information‐sharing behavior within a casual leisure context through 30 semistructured interviews. The findings reveal that the factors influencing individuals' happy information‐sharing behavior are numerous, and impact each other. Most individuals considered sharing happy information important to their friendships and relationships. In various contexts the act of sharing happy information was shown to enhance the sharer's happiness.
Conservative Christian parents’ perceptions of child−parent relationship therapy.

The purpose of our study was to understand, document, and report conservative Christian parents’ perceptions of the effectiveness of an intensive 5-week filial therapy program, ChildParent Relationship Therapy (CPRT). A transcendental phenomenological approach (C. Moustakas, 1994, Phenomenological Research Methods, Thousand Oaks, CA. Sage) was used to gather, analyze, and report the findings from this study. A 14-question, semistructured interview was used with 10 parent participants to ascertain the parents’ perceptions of the CPRT model. Overall, the parents thought the CPRT model was effective and had a positive change on the parent– child relationship and behavior problems the child was experiencing. Several techniques and interventions were described by the parents as the most helpful and beneficial. The results of our study suggest that CPRT may be effective for conservative Christian parents when certain modifications are made. The themes that emerged may be used to provide alternative methods to assist clients who hold conservative Christian beliefs.