Miracle-dz/UniFAR-FTUs huggingface dataset:
Stu2 uses a 15-nm parallel coiled coil for kinetochore localization and concomitant regulation of the mitotic spindle

The yeast microtubule polymerase Stu2’s C-terminal domain is a 15-nm parallel, homodimeric coiled coil with two spatially distinct conserved regions. Determinants in these conserved regions optimally position Stu2 on the mitotic spindle to drive proper spindle structure and dynamics.
The epidemiology of gallstone disease in Rome, Italy. Part II. Factors associated with the disease

The epidemiological associations of gallstone disease were evaluated in a population of 2,325 civil servants (1,244 men and 1,081 women) in Rome, Italy, which was enrolled in a cross‐sectional survey on cholelithiasis. Participants were screened for the presence of gallstones by gallbladder ultrasonography, completed a questionnaire on family and personal history and underwent a physical examination and blood chemistry. Statistically significant associations were established by univariate analysis of the age‐standardized data and by step‐wise multiple logistic regression.
Combined cognitive biases for pain and disability information in individuals with chronic headache: A preliminary investigation

Pain-related cognitive biases have been demonstrated in chronic pain patients, yet despite theoretical predictions are rarely investigated in combination. Combined cognitive biases were explored in individuals with chronic headache (n = 17) and pain-free controls (n = 20). Participants completed spatial cueing (attentional bias), sentence generation (interpretation bias) and free recall tasks (memory bias), with ambiguous sensory-pain, disability and neutral words. Individuals with chronic headache, relative to controls, showed significantly greater interpretation and memory biases favouring ambiguous sensory-pain words and interpretation bias favouring ambiguous disability words. No attentional bias was found. Further research is needed exploring the temporal pattern of cognitive biases.
Altering Trends in the Dominance of Shigella flexneri Serotypes and Emergence of Serologically AtypicalS. flexneri Strains in Dhaka, Bangladesh

ABSTRACT Of 469 recently isolated Shigella flexneri strains, 452 agglutinated with Shigella flexneri-specific monoclonal antibodies. Of these, 396 could be assigned to 10 of the currently recognized 15 serotypes, with S. flexneri 2b dominating (23.2%). Of the 56 untypeable strains which showed invasive properties, 17 were serologically atypical and the remaining 39 belonged to a new serotype.
The effect of inlay butterfly cartilage tympanoplasty technique on compliance

Abstract Conclusion: IBCT technique should be preferred owing to its high graft survival rate and ABG gain. While no significant difference was found in middle ear pressures between ears that underwent IBCT and normal ears, compliance values were found to be decreased in patients undergoing IBCT. However, the lack of correlation between ABG gain and compliance values indicated that compliance increase had no effect on post-operative ABG results. Objective: The aim of the present study was to compare tympanometric and audiological parameters in patients undergoing inlay butterfly cartilage tympanoplasty (IBCT) with their normal ears and to determine their difference with normal ear tympanometric parameters. Methods: Overall, 25 patients that underwent an operation between August 2010–May 2014 were included in the present study. In 13 of these patients, the ear that did not undergo operation was normal. 0.5, 1, 2, 4 kHz pure sound average values, tympanometric measurements and compliance values of normal and operated ears were compared. Results: The graft survival rate in patients was found to be 92%. Mean pre-operative air–bone gap (ABG) was 16.4 ± 5.4 in patients, while mean post-operative ABG was 10.9 ± 5.8, with a statistically significant difference (p = 0.001) While there was no significant difference between operated and normal ears of patients in terms of middle ear pressure (0.441), compliance values were significantly higher in normal ears than those in operated ears (0.032). When post-operative ABG gain was compared with compliance values, no significant correlation was found between ABG gain and compliance measurements (r = −0.025 and p = 0.936).
Screening for speech and language delay: a systematic review of the literature.

Study selection Study designs of evaluations included in the review For intervention: the studies had to detail the number of participants in each group and the nature, duration, span, and delivery of treatment, provide a comparison of preand postintervention speech and language measures, and fulfill one of three design criteria: experimental study with randomised non-treatment controls; quasi-experimental studies (with non-random/pseudo-random or non-equivalent non-treatment control groups); or a single-subject experimental design with graphical displays or session-by-session data for individuals.
Prohormone brain natriuretic peptide (proBNP), BNP and N-terminal-proBNP circulating levels in chronic hemodialysis patients. Correlation with ventricular function, fluid removal and effect of hemodiafiltration

Abstract Background: Brain natriuretic peptide (BNP), N-terminal proBNP (NT-proBNP) and to a lesser extent prohormone proBNP are recognized as biochemical markers of left ventricular dysfunction. In renal failure, interpretation of natriuretic peptide remains unclear, as natriuretic peptide levels may be not only be dependent on cardiac function and dimensions but also on renal function, fluid volume and removal by dialysis procedure including hemodiafiltration (HDF). The purpose of this study was (i) to assess BNP, NT-proBNP and proBNP levels and their correlation with clinical and echocardiographic data in chronic hemodialysis patients, and (ii) to investigate basal level alteration following HDF. Methods: Baseline clinical and echocardiographic parameters were collected in 31 dialysis patients without evidence of cardiac failure. Pre- and post-HDF BNP, NT-proBNP and proBNP concentrations were measured. Correlations between echocardiographic measurements and basal circulating peptides, between changes in peptide values and changes in fluid volume after HDF were investigated. Results: Baseline plasmatic levels were elevated (BNP=517±840 pg/mL, NT-proBNP=5340±6132 pg/mL and proBNP=3569±4683 pg/mL) and correlated with left auricular diameter and left ventricular mass index. HDF session induced a significant decrease of 39%, 59% and 36% for BNP, NT-proBNP and proBNP levels, respectively. This decrease was not correlated to post-HDF fluid removal or weight decrease. Correlation between BNP and proBNP was stronger (r2=0.88) than between NT-proBNP and proBNP (r2=0.54). Conclusions: Despite their elimination, BNP, NT-proBNP and proBNP could be potential markers of left ventricular remodeling in chronic renal failure patients on hemodialysis. According to these results, their cut-off values, however, need to be re-evaluated. Clin Chem Lab Med 2008;46:1019–24.
The Yersinia Effector Protein YpkA Induces Apoptosis Independently of Actin Depolymerization1

The pathogenicity of the plague agent Yersinia pestis is largely due to the injection of effector proteins that potently block immune responses into host cells through a type III secretion apparatus. One Yersinia effector protein, YpkA, a putative serine/threonine kinase, has been reported to act by depolymerizing actin and disrupting actin microfilament organization. Using YpkA-GFP fusion proteins to directly visualize cells expressing YpkA, we found instead that YpkA triggered rapid cell death that can be blocked by caspase inhibitors and Bcl-xL, but was not dependent on caspase-8. The actin depolymerization promoted by YpkA was only seen in cells with other features of apoptosis, and was blocked by inhibiting apoptosis, indicating that actin filament disruption is likely to be a result, rather than a cause of YpkA-induced apoptosis. A region including aa 133–262 in YpkA was sufficient for inducing apoptosis independent of localization to the plasma membrane. These data suggest that YpkA can act as a direct inducer of cell death.
Identification of Special Care Needs: The Comparison of the Cardiothoracic Intensive Care Unit Patient and Nurse

The purposes of this study were to assess (a) the critically ill patient's and critical care nurse's identification and perception of special care needs and (b) the relationship between the patient's and nurse's perception of the identified special care needs. A qualitative approach, using linked data and open-ended surveys, was used to identify common themes and patterns in data. Data collection took place over a 2-month period at a metropolitan research hospital in the Southeast. Common themes and patterns of identified special care needs were recognized across data and with linked data between the patient and nurse. Findings indicate that both nurses and patients feel that the special care needs of the patient are being met. Common needs currently identified by the patient include miscommunication, anxiety, pain, and relaxation. Common needs currently identified by the nurses include pain management, nausea, and comfort.
Essential Oil of Myrtus communis Inhibits Inflammation in Rats by Reducing Serum IL-6 and TNF-α

The topical anti-inflammatory activity of the essential oil of Myrtus communis L. was studied using croton oil induced ear edema and myeloperoxidase (MPO) activity in mice, and cotton pellet induced granuloma, and serum tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in rats. On topical application, the oil exhibited a significant decrease in the ear edema as well as MPO activity. The oil also inhibited cotton pellet-induced granuloma and serum TNF-α and IL-6. It can be concluded that the essential oil of Myrtus communis reduces leukocyte migration to the damaged tissue and exhibits anti-inflammatory activity.
Coping in Adolescents with Cancer

Abstract The dual challenge of normal adolescent development combined with a diagnosis places high demands on the coping of adolescents with cancer (AWC). A review was conducted to synthesize and critique studies of coping in AWC. Findings from this review indicated inconsistent results for developmental and gender differences as well as associations of coping with distress. A number of limitations were associated with these studies, including the use of small samples, lack of consistency in the conceptualization of coping and instruments, and limited knowledge helpful to inform intervention research to improve effective coping in AWC. Future studies are needed to address these limitations.
Medically Serious Suicide Attempters With or Without Plan in Rural China

Abstract Although previous studies have discussed the risk factors of unplanned suicide behavior in several countries, the unplanned suicide attempt in China was not explored in a large sample. We aim to look into the characteristics of unplanned suicide attempters in China and compare them with those suicide attempters with plans. Subjects were 791 medically serious suicide attempters aged 15–54 years in rural China. The sixth item of Beck's Suicide Intent Scale was used to estimate the planned and unplanned suicide attempt. Logistic regression analysis was performed to examine the factors related to planned or unplanned suicide attempt. The results showed that the planned suicide attempts were associated with higher education, hopelessness, and previous suicide act. The unplanned suicide attempt tends to be suicide by pesticide and store pesticide at home. A ban of lethal pesticides may be a method for suicide prevention in rural China.
Latest trends and issues in the ASP service market

Purpose – To provide students and academia with an opportunity to gain an understanding of recent trends and issues regarding the application service providers (ASP) market.Design/methodology/approach – A range of recently published (1999‐2003) works, which provide practical issues, is reviewed to explore the existing pricing models, selecting an ASP and risk/rewards associated with ASPs.Findings – Provides guidance to businesses in selecting an ASP in terms of key questions to be asked and discusses the importance of selecting reliable ASPs. It also recognizes key areas academia should emphasize in teaching students outsourcing of IT.Research limitations/implications – It is not an extensive study of the issues and trends of ASPs. The paper does not review in detail the impact of outsourcing on organizational participants, which perhaps limits its usefulness in a complex business world.Practical implications – A very useful source of information for businesses making outsourcing decisions. The paper prov.
Economic integration in the quality ladder model

Here we perform the same kind of "integration experiments" as in Rivera-Batiz and Romer (1991), this time in the context of a "quality ladder model", where international trade integration is not enough to prevent redundancy of R&D efforts. Thus a further kind of integration is analysed: "financial market integration". We adopt as a setup the Simple Schumpeterian Model in Aghion and Howitt (2005), whose innovation technology differs sharply from the ones conceived by Rivera-Batiz and Romer in that it displays decreasing returns to scale.
Parametric Variation of Chaotic Eigenstates and Phase Space Localization.

We investigate the phase space localization properties of eigenstates of a quantum system pos a chaotic classical limit. Parametric variation of the system suggests introducing a measu correlations between state overlap intensities and level velocities to infer information about the of eigenstate localization. Random matrix theory predicts no correlations. Yet when applied t chaotic stadium billiard, we find large correlations reflecting the significant eigenstate scarring d the parametric action variations of the orbits homoclinic to the central trajectory underlying the packet. The analysis can be applied to data taken with quantum dots in the Coulomb-blockade and microwave cavities. [S0031-9007(96)01650-X]
Partial Anomalous Left Pulmonary Artery along with Aortic Coarctation in an Infant with Kabuki Syndrome

We report an antenatally diagnosed fetal coarctation delivered prematurely and confirmed to have coarctation as well as additional nonobstructing anomalous left pulmonary artery branch (aLPA) from right pulmonary artery (RPA) and significant dysmorphic features. The baby underwent an uncomplicated arch repair, but had numerous multisystem and growth related issues prompting a diagnosis of Kabuki syndrome (KS) at 1 year of age. While coarctation and hypoplastic left heart syndrome are observed in this syndrome, this is the second reported case of aLPA in KS and the first with the forme fruste of left‐sided obstruction as well as aLPA in this group of patients. (Echocardiography 2012;29:E145‐E147)
In Vitro Activity of API-1252, a Novel FabI Inhibitor, against Clinical Isolates of Staphylococcus aureus and Staphylococcus epidermidis

API-1252 (Fig. [1][1]), an inhibitor of bacterial enoyl-acyl carrier protein (enoyl-ACP) reductase (FabI), is being developed by Affinium Pharmaceuticals, Inc. (Toronto, Canada), in both oral and intravenous formulations, for single-agent and combination treatment of antimicrobial-susceptible and -
Epidemiology of amyotrophic lateral sclerosis in the province of Modena, Italy. Influence of environmental exposure to lead

ABSTRACT— A retrospective study of all admissions to the University of Modena Neurological Department from 1976‐1986; 51 cases of amyotrophic lateral sclerosis (ALS) were found. ALS mean annual incidence was 0.78/100,000 inhabitants, while prevalence was 2.35/100,000. Mean age at onset was 61.43 years, mean and median duration of illness were, respectively, 28.83 and 24.5 months, and survival at 5 years post‐onset was 24.4%. A tendency to higher incidence and prevalence of ALS in the ceramic district, when compared with those of the rest of the province was found. However, the small number of cases did not allow any conclusive statistical correlation between environmental exposure to lead and frequency of ALS.
Health care huddles: managing complexity to achieve high reliability.

BACKGROUND Health care huddles are increasingly employed in a range of formats but theoretical mechanisms underlying huddles remain relatively uncharted. PURPOSE A complexity science view implies that essential managerial strategies for high-performing health care organizations include meaningful conversations, enhanced relationships, and a learning culture. These three dimensions informed our approach to studying huddles. We explore new theories for how and why huddles have been useful in health care organizations. METHODS We used a study design incorporating literature review, direct observation, and semistructured interviews. A complexity science framework guided data collection in three health care settings; we also incorporated theories on high-reliability organizations to analyze our observations and interpret huddle participants' perspectives. FINDINGS We identify theoretical paths that could link huddles to improvement in patient safety outcomes. Huddles create time and space for conversations, enhance relationships, and strengthen a culture of safety. Huddles can be of particular value to health care organizations seeking or sustaining high reliability. PRACTICE IMPLICATIONS Achieving high reliability, the organizational capacity to deliver what is intended to be delivered every time is difficult in complex systems. Managers have potential to create conditions from which huddle outcomes that support high reliability are more likely to emerge. Huddles support efforts to improve patient safety when they afford opportunities for heedful interactions to take place among individuals caring for patients and embed mindfulness into the organization.
Reversible effect of X‐irradiation on proliferation, neurogenesis, and cell death in the dentate gyrus of adult mice

Therapeutic cranial X‐irradiation causes cognitive deficits in adult and pediatric patients, in particular, when the exposed area includes the medial temporal lobes. Effects on adult neurogenesis within the hippocampus may be related to such deficits. To investigate this relation, we irradiated the brain of young adult C57Bl/6j mice with a single dose of 4 Gy at a dose‐rate of 27.5 cGy/min. We observed an ∼80% decrease in the number of cells immunoreactive for the proliferation marker Ki67, 16 and 48 h after exposure, which was restored to control values after 1 week. The number of doublecortin‐ and NeuroD‐immunoreactive cells of neuronal lineage was reduced by 60–70% up to 1 week after irradiation, but not after 1 month. The number of pyknotic cells increased ∼2.5 fold after 16 h, decreased to ∼50% of control numbers after 48 h and 1 week, and was again at normal levels after 1 month. Granule cell number did not differ between different groups and time points. There was no apparent activation of microglia or astrocytes. Our findings consist of an acute and reversible effect of X‐irradiation on proliferation, neurogenesis, and cell death. Transient changes of neurogenesis may play a role in transient impairments of cognitive performance of patients exposed to X‐irradiation. We present an experimental approach to temporarily alter adult hippocampal neurogenesis (AhN), allowing mechanistic investigations of AhN and its relevance to cognitive performances. The work also represents a step toward optimized radiotherapy schedules. © 2007 Wiley‐Liss, Inc.
Holding-side influences on infant's view of mother's face

Recently we found that adult children whose mothers had had a right-arm preference for holding infants have a reduced left bias for recognising faces, suggesting that they are less well right-hemisphere lateralised for perceiving faces. One possible explanation of this finding is that early visual exposure to faces is suboptimal for right-held infants. To test this idea, we asked mothers to pick up a doll with an inbuilt camera in its face and to start bottle-feeding it. The results showed that less was visible of the face of mothers who held the doll on their right arm in comparison to those who held the doll on their left arm: From the right arm, the mother's left half of the face was less visible when the mothers were looking up and their right half of the face was less visible when they were looking at the doll. These results suggest that right-held infants receive suboptimal information from faces. Because early face exposure is important for face-processing development, the suboptimal face exposure probably experienced by right-held infants may have consequences for their ability to recognise faces and facial emotion later in life.
The Establishment of a Non-Invasive Continuous Blood Pressure Measure System Based on Pulse Transit Time

Most non-invasive continuous blood pressure (BP) meters are developed based on principles of oscillometry, tonometry and pulse transit time (PTT). Compared with apparatus based on oscillometry and tonometry, apparatus using PTT to monitor BP is more suitable in space because the sensors which used have simple structure and wear comfortably. A novel method to calculate arterial blood pressure by using wavelet transform to detect the peak value of pulse wave and calculate pulse transit time accurately is introduced, and which was applied in the non-invasive continuous blood pressure measure system. The system has solved problems such as low accuracy and lack of synchronism in collecting ECG and pulse wave signal which exist in other system based on pulse wave velocity. The system has been applied to astronaut's daily training and provides a new technique and instrument for non-invasive continuous blood pressure measure in space.
Presidential Address: The Corporation in Finance

To produce significant net present value, an entrepreneur has to differentiate her enterprise from the ordinary. To take collaborators with her, she needs to have substantial ownership, and thus financing. But it is hard to raise finance against differentiated assets. So an entrepreneur has to commit to undertake a second transformation, standardization, that will make the human capital in the firm, including her own, replaceable, so that outside financiers obtain control rights that will allow them to be repaid. A vibrant stock market helps the entrepreneur commit to these two transformations. The nature of firms and financing are intimately linked. ONE OF THE CORNERSTONES of modern corporate finance is the Modigliani-Miller Theorem, which essentially says that, in a world where investors can borrow and lend as easily as corporations, the value of a firm is determined by the present discounted value of its expected cash flows, and not by how these cash flows are allocated to various claimholders. A firm's capital structure is therefore irrelevant to its value, or taken literally, much of what corporate finance spends its time on is of second-order importance. Corporate finance researchers have spent the years since Modigliani and Miller (1958) trying to prove the value of their field by challenging one as- sumption after another of the near-perfect world that Modigliani and Miller postulate. Modigliani and Miller themselves acknowledge the tax deductability of interest, which would imply that firm value should increase with leverage. Seminal contributions by Jensen and Meckling (1976) and Myers (1977) show that capital structure choices affect the firm's investment decisions. These con- tributions have been followed by Myers and Majluf (1984), who suggest that information asymmetries between management and investors also influence the choice of securities that are issued, and hence corporate investment, and by Jensen (1986), who proposes that debt disciplines managerial waste. Corpo- rate finance has thus responded well to the challenge posed by Modigliani and