Miracle-dz/UniFAR-FTUs huggingface dataset:
Multitasking and Subjective Performance Evaluations: Theory and Evidence from a Field Experiment in a Bank

We study the incentive effects of grating supervisors access to objective performance information when agents work on multiple tasks. We first analyze a formal model showing that incentives are lower powered when supervisors have no access to objective measures but assess performance subjectively by gathering information. This incentive loss is more pronounced when the span of control is larger and incentives are distorted towards more profitable tasks. We then investigate a field experiment conducted in a bank. In the treatment group managers obtained access to objective performance measures which raised efforts and profits. We find that the effects are driven by larger branches and lower margin products.
Industrial policy for a Europeanindustrial renaissance. A few reflections

This paper raises and attempts to address three questions that add to the recent debate on industrial policies to promote a European “industrial renaissance”. We ask (i) What type of de-industrialisation represents a threat for Europe? (ii) What type of structural change can industrial policy steer in a context of increasing international fragmentation of production, both across European countries and worldwide? (iii) What type of industrial policy shall we advocate, that goes beyond the manufacturing sectors? With no pretence to provide all the answers or yet another wish list of policy tools, we argue that we are “doomed to choose” (Hausmann and Rodrik, 2006) what type of structural transformation is Europe in need of, in a context of harsher global competition from the emerging countries; of staggering income polarisation within Europe itself; of relentless international fragmentation of production processes. First, we claim that industrial policy should target sectors and segments of value chains that support the manufacturing sector and not necessarily represent a hollowing out of the industrial base. Second, industrial policy should target structural transformation alongside large “missions” and learn from classical debates on industrialisationled development. Interventions should therefore go beyond the traditional vertical versus horizontal tools distinction and complement a “mission oriented” plea with other tools, to avoid yet another “one size fits all” approach.
Synopsis of Central Andean Orthalicoid land snails (Gastropoda, Stylommatophora), excluding Bulimulidae

Abstract A faunal overview is presented of the molluscan families Amphibulimidae, Megaspiridae, Odontostomidae, Orthalicidae, Simpulopsidae in Bolivia, Ecuador, and Peru. These Central Andean countries are known for their biodiverse malacofauna, of which the superfamily Orthalicoidea takes relatively a large share. In this paper the five families containing 103 (sub)species, for which systematic information (original publication, type locality, type depository, summarizing literature) and distributional records are presented. All species are illustrated by photographs of the type material or, if this could not be located, by a reproduction of the original figure. The following new taxon is introduced: Thaumastus (Thaumastus) sumaqwayqu sp. n. Junior subjective synonyms are established for: Plekocheilus (Sparnotion) Pilsbry, 1944 = Plekocheilus (Eudolichotis) Pilsbry, 1896; Scholvienia (Thomsenia) Strebel, 1910 = Scholvienia Strebel, 1910; Sultana (Trachyorthalicus) Strebel, 1909 = Sultana (Metorthalicus) Pilsbry, 1899; Plekocheilus (Eurytus) conspicuus Pilsbry, 1932 = Thaumastus (Thaumastus) hartwegi (Pfeiffer in Philippi, 1846); Zebra gruneri Strebel, 1909 = Orthalicus maracaibensis (Pfeiffer, 1856); Scholvienia jaspidea minor Strebel, 1910 = Scholvienia alutacea (Reeve, 1850); Bulimus bifasciatus unicolor Philippi, 1869 = Scholvienia brephoides (d’Orbigny, 1835). A new status is given to Plekocheilus mcgintyi ‘Pilsbry’ H.B. Baker, 1963 (subspecies of Bulinus piperitus Sowerby I, 1837); Strophocheilus superstriatus var. prodeflexus Pilsbry, 1895 (subspecies of Bulinus piperitus Sowerby I, 1837); Thaumastus (Quechua) salteri maximus Weyrauch, 1967 (subspecies of Thaumastus (Quechua) olmosensis Zilch, 1954); Pseudoglandina agitata Weyrauch, 1967 (nomen inquirendum). New combinations are: Clathrorthalicus corydon (Crosse, 1869), and Cyclodontina chuquisacana (Marshall, 1930). Lectotypes are now designated for Bulimus incisus Hupé, 1857 and Bulinus piperitus Sowerby I, 1837.
Withdrawal Reactions Associated with Venlafaxine

Objective: The aim of this paper is to describe discontinuation syndromes associated with abrupt and tapered withdrawal of venlafaxine, and to document that withdrawal symptoms may occur after missing a single dose. Clinical picture: We report on two patients prescribed venlafaxine. One developed a broad range of serious side effects after reaching a dose of 300 mg a day, and a severe withdrawal syndrome (including hallucinations) during a slow taper regime. The second had severe discontinuation symptoms during and aborting a slow taper regime, and described withdrawal responses after missing a single dose of venlafaxine. Conclusions: As for the short-acting selective serotonin re-uptake inhibitors, severe discontinuation reactions may occur with venlafaxine, seemingly marked most distinctly by headache, nausea, fatigue, dizziness and dysphoria, and may make cessation of the drug extremely difficult. Two strategies for addressing the concern are considered.
Differential effect of nerve injury at birth on the activity pattern of reinnervated slow and fast muscles of the rat.

The activity patterns of the reinnervated slow soleus and fast extensor digitorum longus (e.d.l.) muscles were studied in rats during the first 6 months after sciatic nerve crush at birth, using chronic electromyography. When the nerve lesion was inflicted shortly after birth, the recovery of the muscle weight and size was always much less than if the same lesion was inflicted on adult animals. As previously demonstrated, this effect is due to motoneurone and muscle fibre loss. Following reinnervation after a neonatal crush, the soleus muscle recovered its normal tonic activity pattern during postural and spontaneous locomotor activity. By contrast, in the reinnervated e.d. l. muscle, abnormal tonic motor unit activity was recorded during locomotion, in addition to the phasic activity characteristic of the normal muscle. In response to postural reflexes elicited by tilting the animal, tonic motor unit activity was recorded from the reinnervated e.d. l. muscle, whereas the normal muscle was not activated by these stimuli. The aggregate activity recorded from the reinnervated e.d. l. during spontaneous locomotion was about 2‐3 times greater than normal, whereas in the reinnervated soleus no significant change took place. In animals which had their nerves crushed as adults, the activity pattern and aggregate activity of both muscles was similar to normal. The firing pattern of individual motor units from normal and reinnervated muscles was compared. After a neonatal crush, the mean frequency of firing of e.d. l. motor units was significantly lower compared to normal or to that after an adult crush, whereas in soleus no significant change was found. These results indicate that peripheral nerve lesions during early development affect predominantly the development of motoneurones with a phasic, high‐frequency discharge pattern resulting in a shift towards tonic, lower‐frequency motor unit activity.
Is the Grafted Tendon Shifted Anteriorly in the Femoral Tunnel at the Postremodeling Phase After Anterior Cruciate Ligament Reconstruction? A Clinical MRI Study

Background: Based on previous in vitro studies, it has been commonly believed that during anterior cruciate ligament (ACL) reconstruction with hamstring tendon, the grafted tendon is shifted anteriorly in the tunnel permanently after the graft is anchored to the tunnel wall. However, this has not been proven by in vivo studies. Hypothesis: At 1 year after anatomic double-bundle ACL reconstruction, the grafted tendons may not be shifted anteriorly in the femoral tunnel but anchored to the bony wall at the center of the tunnel. Study Design: Case series; Level of evidence, 4. Methods: Participants consisted of 40 patients who underwent anatomic double-bundle ACL reconstruction. The grafted tendons located in the femoral tunnel were examined 1 year after surgery using 2 different magnetic resonance imaging (MRI) protocols. In the first substudy, with 20 patients, the grafted tendon location was evaluated on an inclined sagittal multiplanar reconstruction (MPR) image taken using a standard T2-weighted protocol. In the second substudy with the remaining 20 patients, tendon location was evaluated on a pure axial MPR image taken using a VISTA (volume isotropic turbo spin echo acquisition) protocol. Results: On the inclined sagittal T2-weighted images of the anteromedial (AM) graft, the anterior width of the newly formed fibrous tissue, which surrounded the tendon graft, was significantly greater than the posterior width (P = .001). The center of the grafted tendon was slightly (mean, 2.5% of the tunnel diameter) but significantly (P = .0310) shifted posteriorly from the tunnel center. On the axial T2-VISTA images, the center of the AM graft was slightly but significantly shifted posteriorly (3.9%; P = .022) and medially (5.5%; P = .002) from the tunnel center. The center of the posterolateral (PL) graft was not significantly shifted to any direction from the center of the tunnel. Conclusion: The grafted tendons were not shifted anteriorly in the femoral tunnel 1 year after anatomic double-bundle ACL reconstruction. The PL graft was located approximately at the center of the tunnel outlet, while the AM graft was slightly but significantly shifted posteriorly and proximally.
Corporate Foreign Bond Issuance and Interfirm Loans in China

This paper uses firm-level data to document and analyze international bond issuance by Chinese non-financial corporations and the use of the proceeds of issuance. We find that dollar issuance is positively correlated with the differential between domestic and foreign interest rates. This interest rate differential increases the likelihood of dollar bond issuance by risky firms and decreases the likelihood of dollar bond issuance of exporters and profitable firms. Moreover, and most strikingly, we find that risky firms do more inter-firm lending than non-risky firms and that this lending rose significantly after the regulatory shock of 2008-09, when the authorities sought to restrict the financial activities of risky firms. Risky firms try to boost profitability by engaging in speculative activities that mimic the behavior of financial institutions while escaping prudential regulation that limits risk-taking by financial firms.
The Welfare Trait: How State Benefits Affect Personality.

The Welfare Trait: How State Benefits Affect Personality By Adam Perkins. Palgrave Macmillan. 2016. £20.00 (pb). 201 pp. ISBN 9781137555281 In this book, Adam Perkins, neurobiologist of personality, makes a powerful claim: namely, that social policy structure can influence personality function:
Human Mena+11a Isoform Serves as a Marker of Epithelial Phenotype and Sensitivity to Epidermal Growth Factor Receptor Inhibition in Human Pancreatic Cancer Cell Lines

Purpose: hMena, member of the enabled/vasodilator-stimulated phosphoprotein family, is a cytoskeletal protein that is involved in the regulation of cell motility and adhesion. The aim of this study was to determine whether or not the expression of hMena isoforms correlated with sensitivity to EGFR tyrosine kinase inhibitors and could serve as markers with potential clinical use. Experimental Design: Human pancreatic ductal adenocarcinoma cell lines were characterized for in vitro sensitivity to erlotinib, expression of HER family receptors, markers of epithelial to mesenchymal transition, and expression of hMena and its isoform hMena+11a. The effects of epidermal growth factor (EGF) and erlotinib on hMena expression as well as the effect of hMena knockdown on cell proliferation were also evaluated. Results: hMena was detected in all of the pancreatic tumor cell lines tested as well as in the majority of the human tumor samples [primary (92%) and metastatic (86%)]. Intriguingly, in vitro hMena+11a isoform was specifically associated with an epithelial phenotype, EGFR dependency, and sensitivity to erlotinib. In epithelial BxPC3 cells, epidermal growth factor up-regulated hMena/hMena+11a and erlotinib down-regulated expression. hMena knockdown reduced cell proliferation and mitogen-activated protein kinase and AKT activation in BxPC3 cells, and promoted the growth inhibitory effects of erlotinib. Conclusions: Collectively, our data indicate that the hMena+11a isoform is associated with an epithelial phenotype and identifies EGFR-dependent cell lines that are sensitive to the EGFR inhibitor erlotinib. The availability of anti-hMena+11a–specific probes may offer a new tool in pancreatic cancer management if these results can be verified prospectively in cancer patients.
Immunologic mechanisms in the induction and regression of Shope papilloma virus-induced epidermal papillomas of rats.

Shope papilloma virus can readily induce epidermal papillomas in rabbits but rats show a high level of resistance to tumor induction. Tumors have not been induced in the skin of adult rats but when fetal rat skin is infected and grafted to syngeneic adult recipients (Lewis strain), papillomas develop in about 7–10% of the grafts. These tumors invariably regress within one week. The regression is always accompanied by an intensive lymphocytic infiltration. If this papilloma regression is mediated by an immune response, then it should be inhibited by immunosuppressive agents. For this purpose, adult rats were treated by a variety of methods. In the first series, varying doses of methylprednisolone were used. In the second series, anti-rat lymphocyte sera prepared in sheep or horses, were used either alone or in combination with adult thymectomy. All of the immunosuppressive methods resulted in prolongation of survival of the pappillomas. The best results were obtained with a combination of adult thymectomy and horse anti-rat lymphocyte serum. The original low incidence of papillomas (7–10%) was not increased by immunosuppression. It is concluded that an immunological mechanism is probably operative in the papilloma regression but that other mechanisms of resistance are responsible for the low initial incidence of papillomas.
Increased dihydrofolate reductase synthesis in Diplococcus pneumoniae following translatable alteration of the structural gene. 3. Further evidence on the extent of genic involvement.

VIDENCE for the occurrence of mutation in the dihydrofolate reductase E gene of Diplococcus pneumoniae, which alters both the amount and structure of the corresponding enzyme, has been presented in two previous reports from this laboratory. (SIROTNAK and HACHTEL 1969; SIROTNAK, WILLIAMS and HACHTEL 1969). This form of dual biochemical effect is similar in some respects to that observed in the L-arabinose operon of Escherichia coli (ENGLESBERG 1961; LEE and ENGLESBERG 1963) and appears to involve an increase in the rate of dihydrofolate reductase synthesis as a result of a “missense” alteration of the structural gene. Other genetic and enzymological findings lending further support to this idea are presented here. In addition to their effect on antifolate binding by the enzyme, a number of these mutations was also found to have a marked effect on stability. Of special significance, also, are results indicating that increased levels of dihydrofolate reductase are not due to genetic alteration of only a specific region of the gene, but occur as a result of mutation at any one of a large number of sites encompassing a major portion, if not all, of the gene. Data relating to a number of extreme dual-effect mutations were presented in a preliminary report ( SIROTNAK 1969). Recent evidence was also given by BERBERICH and LEVINTHAL (1969) for the occurrence of a similar type of mutation in the dihydrofolate reductase gene of Salmonella typhimurium. MATERIALS AND METHODS Many of the procedures used during the present study have already been described in detail (SIROTNAK and HACHTEL 1969; SIROTNAK, WILLIAMS and HACHTEL 1969). Media used for the isolation of mutant strains, for genetic experiments and for culture production have also been given (SIROTNAK, LUNT and HUTCHISON 1964).
Three essays on the informational efficiency of financial markets through the use of Big Data Analytics

The massive increase in the availability of data generated everyday by individuals on the Internet has made it possible to address the predictability of financial markets from a different perspective. Without making the claim of offering a definitive answer to a debate that has persisted for forty years between partisans of the efficient market hypothesis and behavioral finance academics, this dissertation aims to improve our understanding of the price formation process in financial markets through the use of Big Data analytics. More precisely, it analyzes: (1) how to measure intraday investor sentiment and determine the relation between investor sentiment and aggregate market returns, (2) how to measure investor attention to news in real time, and identify the relation between investor attention and the price dynamics of large capitalization stocks, and (3) how to detect suspicious behaviors that could undermine the in-formational role of financial markets, and determine the relation between the level of posting activity on social media and small-capitalization stock returns. The first essay proposes a methodology to construct a novel indicator of investor sentiment by analyzing an extensive dataset of user-generated content published on the social media platform Stock-Twits. Examining users’ self-reported trading characteristics, the essay provides empirical evidence of sentiment-driven noise trading at the intraday level, consistent with behavioral ﬁnance theories. The second essay proposes a methodology to measure investor attention to news in real-time by combining data from traditional newswires with the content published by experts on the social media platform Twitter. The essay demonstrates that news that garners high attention leads to large and persistent change in trading activity, volatility, and price jumps. It also demonstrates that the pre-announcement eﬀect is reduced when corrected newswire timestamps are considered. The third essay provides new insights into the empirical literature on small capitalization stocks market manipulation by examining a novel dataset of messages published on the social media plat-form Twitter. The essay proposes a novel methodology to identify suspicious behaviors by analyzing interactions between users and provide empirical evidence of suspicious stock recommendations on social media that could be related to market manipulation. The conclusion of the essay should rein-force regulators’ eﬀorts to better control social media and highlights the need for a better education of individual investors.
Immunological Subsets Characterization in Newly Diagnosed Relapsing–Remitting Multiple Sclerosis

Objectives Using flow cytometry, we characterized myeloid, B, and T cells in patients recently diagnosed with relapsing–remitting multiple sclerosis (RRMS) naive to disease-modifying therapies (DMTs). Methods This prospective case–control study was conducted in the tertiary MS center of Catania, Italy. Demographic/clinical data and peripheral bloods were collected from 52 naive patients recently diagnosed with RRMS and sex/age-matched healthy controls (HCs) in a 2:1 ratio. We performed flow cytometry on isolated peripheral blood mononuclear cells to assess immune cell subsets differences between RMMS patients and HCs. We explored the biomarker potential of cell subsets using receiver operating characteristic (ROC) curves and relative area under the curve (AUC) analyses. Results Monocytic myeloid-derived suppressor cells (Mo-MDSCs CD14+/HLADR−/low) and inflammatory monocytes (CD14+CD16+) displayed higher frequencies in RRMS patients when compared with HCs (p <.05). A lower percentage of B-unswitched memory cells was observed in RRMS patients when compared with HCs (p = .026). T cells had a higher frequency of T-helper CD4+ cells and their subset, CD4+CD161+, in RRMS patients when compared with HCs (p <.001). ROC analyses revealed an AUC >70% for Mo-MDSCs CD14+/HLADR−/low and inflammatory CD14+CD16+, T-helper CD3+CD4+, and T-helper CD4+CD161+. Conclusions Patients with a recent RRMS diagnosis and naive to DMTs, showed peculiar myeloid, B-, and T-cell immunophenotypes.
Mammary Reconstruction Using Tissue Expander and Partial Detachment of the Pectoralis Major Muscle to Expand the Lower Breast Quadrants

The techniques commonly used in breast reconstruction with tissue expanders do not provide a good definition of the lower breast quadrant. With the authors’ technique a better profile of the breast is achieved. Partial detachment of the pectoral muscle is performed, suturing it to the lower skin flap and thereby avoiding cranial migration of the expander. In addition a rounded shape of the lower quadrants is achieved and the expander remains in a subcutaneous position.
Hemicranial Attacks or Permanent Hemicrania — A Sequel of Upper Cervical Root Compression

After many years of unsuccessful conservative treatment 16 patients suffering from hemicrania are relieved of their pain or are improved by operative treatment. Hemicranial attacks or permanent hemicrania is found to be caused by upper cervical nerve root compression. Vascular compression of C2 (n = 9) or scar tissue surrounding C2 (n = 1) or C3 (n = 1) is the pathology identified in cases of cervicogenic headache or “cluster headache-like” headache. Compression attributable to tumor, prolapsed disc, or spondylotic changes is found to be a cause of permanent headache. Only in those patients with permanent headache are radiological or electrophysiological findings helpful for diagnosis. In patients with hemicranial attacks and compression of nerve root C2 (n = 10) or C3 (n = 1), only vasoactive tests (provoking or relieving pain) or local anaesthesia prove to be helpful in diagnosing and localizing the origin of pain. The operation involves freeing the nerve roots from vascular compression. In two patients the C2 ganglion is resected. Thirteen patients subsequently become pain free. In three patients, hemicrania improves. Four of the 16 patients experience a recurrence of pain after the decompressive operation. After additional thermorhizotomy two patients have no further complaints and one patient has improved. One patient can tolerate his pain with occasional analgesics. The problem of referred pain into the fronto-ocular region is discussed.