Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of Aldehyde Dehydrogenase 2 Gene Polymorphism on Hemodynamics After Nitroglycerin Intervention in Northern Chinese Han Population

Background: Nitroglycerin (NTG) is one of the few immediate treatments for acute angina. Aldehyde dehydrogenase 2 (ALDH2) is a key enzyme in the human body that facilitates the biological metabolism of NTG. The biological mechanism of NTG serves an important function in NTG efficacy. Some reports still contradict the results that the correlation between ALDH2 gene polymorphisms and NTG and its clinical efficacy is different. However, data on NTG measurement by pain relief are subjective. This study aimed to investigate the influence of ALDH2 gene polymorphism on intervention with sublingual NTG using noninvasive hemodynamic parameters of cardiac output (CO) and systemic vascular resistance (SVR) in Northern Chinese Han population. Methods: This study selected 559 patients from the Affiliated Hospital of Qingdao University. A total of 203 patients presented with coronary heart disease (CHD) and 356 had non-CHD (NCHD) cases. All patient ALDH2 genotypes (G504A) were detected and divided into two types: Wild (GG) and mutant (GA/AA). Among the CHD group, 103 were wild-type cases, and 100 were mutant-type cases. Moreover, 196 cases were wild-type, and 160 cases were mutant type among the NCHD volunteers. A noninvasive hemodynamic detector was used to monitor the CO and the SVR at the 0, 5, and 15 minute time points after medication with 0.5 mg sublingual NTG. Two CO and SVR indicators were used for a comparative analysis of all case genotypes. Results: Both CO and SVR indicators significantly differed between the wild and mutant genotypes at various time points after intervention with sublingual NTG at 5 and 15 minutes in the NCHD (F = 16.460, 15.003, P = 0.000, 0.000) and CHD groups (F = 194.482, 60.582, P = 0.000, 0.000). All CO values in the wild-type case of both NCHD and CHD groups increased, whereas those in the mutant type decreased. The CO and &Dgr;CO differences were statistically significant (P < 0.05; P < 0.05). The SVR and &Dgr;SVR changed between the wild- and mutant-type cases at all-time points in both NCHD and CHD groups had statistically significant differences (P < 0.05; P < 0.05). Conclusion: ALDH2 (G504A) gene polymorphism is associated with changes in noninvasive hemodynamic parameters (i.e. CO and SVR) after intervention with sublingual NTG. This gene polymorphism may influence the effect of NTG intervention on Northern Chinese Han population.
Comparative study of MALDI-TOF MS and VITEK 2 in bacteria identification.

BACKGROUND Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) has recently been introduced in diagnostic microbiology laboratories for the identification of bacterial and yeast strains isolated from clinical samples. This study aimed to evaluate the accuracy of MALDI-TOF MS in clinical microbiology diagnosis by comparing it with commonly-used VITEK 2 or gene sequencing. METHODS The performances of MALDI-TOF MS and VITEK 2 were compared retrospectively for identifying routine isolates. Discrepancies were analyzed by gene sequencing analysis of the 16S genes. RESULTS For 1,025 isolates, classified as 55 species of 25 genera, 1,021 (99.60%) isolates were accurately identified at the genus level, and 957 (93.37%) isolates at the species level by using MALDI-TOF MS. A total of 949 (92.59%) isolates were completely matched by both methods. Both methods found 76 unmatched isolates among which one strain had no definite identification by MALDI-TOF MS and VITEK 2 respectively. However, MALDI-TOF MS made no errors at the genus level while VITEK 2 made 6 (0.58%) errors at the genus level. At the species level, the identification error rates for MALDI-TOF MS and VITEK 2 were 5.56% and 6.24%, respectively. CONCLUSIONS With a lower identification error rate, MALDI-TOF MS has better performance than VITEK 2 in identifying bacteria found routinely in the clinical laboratory. It is a quick and cost-effective technique, and has the potential to replace conventional phenotype methods in identifying common bacterial isolates in clinical microbiology laboratories.
Impact of the load in the detection of bearing faults by using the stator current in PMSM's

Many mechanical faults in industrial processes are related to bearing damage, which can be detected by vibration analysis. This approach may be expensive due to the cost of sensors. Therefore, studies are performed in order to use the stator current to detect bearing damage. This study is to investigate the impact of the load in the bearing damage detection by using the stator current. A diagnostic index is developed and evaluated for vibration signals measured from a healthy and a damaged bearing. Afterwards, the validated index is applied to the stator current of a permanent magnet synchronous machine measured with a healthy and a damaged bearing at different loads. The results show that, the damaged bearing can be differentiated from the healthy bearing by using the proposed index with the signal of the vibration or the stator current. However, the detection by the stator current is strongly dependent on the radial force of the bearing.
Annotated type catalogue of the Orthalicoidea (Mollusca, Gastropoda) in the Royal Belgian Institute of Sciences, Brussels, with descriptions of two new species

Abstract The type status is described of 57 taxa from the superfamily Orthalicoidea in the collection of the Brussels museum. Two new species are described: Stenostylus perturbatus sp. n. , and Suniellus adriani sp. n. New lectotypes are designated for Bulimulus (Naesiotus) amastroides Ancey, 1887; Bulimulus blanfordianus Ancey, 1903; Bulimulus montivagus chacoensis Ancey, 1897; Bulimus coloratus Nyst, 1845; Plecochilus dalmasi Dautzenberg, 1900; Placostylus porphyrostomus elata Dautzenberg, 1923; Bulimulus ephippium Ancey, 1904; Bulimus fulminans Nyst, 1843; Bulimus funckii Nyst, 1843; Orphnus thompsoni lutea Cousin, 1887; Bulimus melanocheilus Nyst, 1845; Orphnus thompsoni nigricans Cousin, 1887; Orphnus thompsoni olivacea Cousin, 1887; Bulimulus pollonerae Ancey, 1897; Orphnus thompsoni zebra Cousin, 1887. New combinations are: Bostryx borellii (Ancey, 1897); Bostryx carandaitiensis (Preston, 1907); Protoglyptus mazei (Crosse, 1874); Kuschelenia (Vermiculatus) sanborni (Haas, 1947). New synonymies are established for the following nominal taxa: Orphnus thompsoni var. lutea Cousin, 1887 = Kara thompsonii (Pfeiffer, 1845); Orphnus thompsoni var. nigricans Cousin, 1887 = Kara thompsonii (Pfeiffer, 1845); Thaumastus nystianus var. nigricans Cousin, 1887 = Drymaeus (Drymaeus) nystianus (Pfeiffer, 1853); Orphnus thompsoni var. olivacea Cousin, 1887 = Kara thompsonii (Pfeiffer, 1845); Orphnus thompsoni var. zebra Cousin, 1887 = Kara thompsonii (Pfeiffer, 1845).
Nasopharyngeal pH and gastroesophageal reflux in children with chronic respiratory disease.

OBJECTIVES The aim of this case-control study was to evaluate the nasopharyngeal pH (NasopH) in children with normal or abnormal pH-metry in two groups of patients; 1) children presenting gastroenterological symptoms; and 2) children with chronic respiratory symptoms. METHODS From February 2004 to January 2005, all consecutive patients referred for 24-hour pH-metry and in whom gastroesophageal reflux disease was suspected were enrolled in a prospective study. They were assigned to four groups: gastroenterological symptoms with normal (A) or abnormal (B) pH-metries (GG), and chronic respiratory symptoms with normal (C) or abnormal (D) pH-metries (RG). NasopH was measured for 5 minutes, before the 24-hour test was performed. RESULTS Thirty-eight pH-metry tests were included (20 in the RG and 18 in the GG). Abnormal pH-metry results were observed in 11 patients in the GG and in 12 in the RG. NasopH means were 6.3273 and 5.6917, respectively (p<0.0001). Average nasopharyngeal pH was 5.6917 among the 12 RG patients with abnormal pH-metry results and 6.5000 among the remaining eight patients with normal test results (p=0.0006). Analysis of the RG with a receiver operating characteristic (ROC) curve showed pH of 5.8 as cutoff point (sensitivity of 91.7% and specificity of 87.5%). The area below the ROC curve was 0.870. CONCLUSIONS Nasopharyngeal pH is significantly lower among patients in the RG presenting abnormal pH-metry results. A 5.8 NasopH has good sensitivity and specificity and can be used as a screening test in patients with chronic respiratory diseases to select those for whom conventional 24-hour pH-metry is indicated.
Towards a global water scarcity risk assessment framework: incorporation of probability distributions and hydro-climatic variability

Changing hydro-climatic and socioeconomic conditions increasingly put pressure on fresh water resources and are expected to aggravate water scarcity conditions towards the future. Despite numerous calls for risk-based water scarcity assessments, a global-scale framework that includes UNISDR’s definition of risk does not yet exist. This study provides a first step towards such a risk-based assessment, applying a Gamma distribution to estimate water scarcity conditions at the global scale under historic and future conditions, using multiple climate change and population growth scenarios. Our study highlights that water scarcity risk, expressed in terms of expected annual exposed population, increases given all future scenarios, up to >56.2% of the global population in 2080. Looking at the drivers of risk, we find that population growth outweigh the impacts of climate change at global and regional scales. Using a risk-based method to assess water scarcity, we show the results to be less sensitive than traditional water scarcity assessments to the use of fixed threshold to represent different levels of water scarcity. This becomes especially important when moving from global to local scales, whereby deviations increase up to 50% of estimated risk levels.
Analysis of ANC Levels after Filgrastim Therapy in Acute Leukemia Children with Neutropenia

Cytotoxic chemotherapy suppresses the hematopoietic system, and the most serious hematologic toxicity is neutropenia. This can decrease a risk of infection that causes delays in treatment and reduction of dose intensity, which reduces therapeutic outcome. Filgrastim is used to increase neutrophils level whose therapeutic effect is unknown. The effectiveness of filgrastim is based on the ANC level pre- and post-therapy. This study aimed to analyze the use of filgrastim on ANC level changes in acute leukemia children with neutropenia, and to analyze the patient that achieve ANC level’s targeted therapy = 1000 cell/mm3. A prospective observational study with a longitudinal design was conducted from June to October 2016. The inclusion criteria of the study were patients who diagnosed acute leukemia with neutropenia and received filgrastim 10 µg/kgBW for 3, 4, 5 days. Patients’ ANC levels were measured before and after filgrastim therapy. This study has been approved its ethical clearance by Dr. Saiful Anwar Hospital, Malang. Data were obtained on the basis of neutropenic episodes, followed by 7 episodes of obtaining filgrastim for 3 days, 1 episode of obtaining filgrastim for 4 days, and 7 episodes of obtaining filgrastim for 5 days. Thus, it consists of 15 episodes. In 3 days, ANC levels increased by 9.5 fold from 381.3 ± 91.8 cell/mm3 to 3984.9 ± 426.8 cell/mm3, but in 5 days, ANC levels decreased by 0.9 fold from 200.9 cell/mm3 ± 98.2 to 189.7 ± 14.2 cell/mm3. Filgrastim was able to increased the ANC levels around nine fold for 3 days of theraphy. There were 53% neutropenia patients who achieved the goal of therapy. Filgrastim therapy with dose 10 µg/kgBW for 3 to 5 days has been able to reach the therapeutic target of 53% in acute leukemia children with neutropenia. The increased levels of ANC maximum was reached on the third day with increased levels of 9.5 fold.
Risk factors of metabolic syndrome among food suppliers

Akbar BARZEGAR Kermanshah University of Medical Sciences School of Public Health, Department of Occupational Health Engineering Dolat Abad, Isar Square, Kermanshah, Iran barzegarakbar@gmail.com SUMMARY Introduction/Objective As a risk factor for chronic diseases, metabolic syndrome (MS) is increasing at an alarming rate. The prevalence of MS varies according to lifestyle and occupation in different populations. The present study aimed to determine the prevalence of MS and its components in food suppliers. Methods A total of 112 food suppliers were randomly selected from all around the city. Data collection tools included demographic, physical activity, and food frequency questionnaires. Body composition was measured using Bio-Electrical Body Analyzer. A sample of 5 ml of fasting blood was taken from participants to assess lipid profile, blood sugar, insulin, and liver enzymes. The data were analyzed using χ2, Kolmogorov–Smirnov and ANOVA tests. Results Participants’ mean BMI was 27.1 ± 3.9 kg/m2, 43.6% were overweight, and 26.4% were obese. Consumption of vegetables was less and of meats more than recommended amounts. The prevalence of MS was 45.5% (51 people), which increased with aging (p = 0.02). Among factors causing MS, the most common one was waist-to-hip ratio (WHR) > 0.09 (72.7%), followed by high triglyceride and low HDL. Conclusion In this study, the prevalence of MS among food suppliers was higher than the world average and than prevalence in other countries. WHR (or obesity) was found to be the most important risk factor for MS. To reduce the risk of MS, changing dietary consumption habits and increased physical activity are recommended to persons with high risk and sedentary occupations.
Association of Physical Fitness With LDL and HDL Subfractions in Young Healthy Men

A dyslipoproteinemia of increased concentrations of small, dense LDL particles and reduced HDL2 cholesterol has shown to be associated with coronary heart disease (CHD). In contrast, an increase in physical fitness and a reduction of body mass index (BMI) improve the lipoprotein profile and reduce the incidence of cardiovascular events. The association of physical exercise, physical fitness, and body weight with an atherogenic lipoprotein subfraction profile has been investigated before in obese subjects, but the relationship is unknown in a healthy non-obese population without insulin resistance or CHD. Therefore, a detailed lipoprotein subfraction profile of 3 HDL and 6 LDL subfractions was determined in 125 healthy men (26+/-5 years). Physical fitness (maximal oxygen consumption, VO2max) was assessed by ergometry and physical activity by questionnaire. Those men with the lowest physical fitness (VO2max < 40 ml/kg/min) and the lowest physical activity score had a significantly less favourable lipoprotein subfraction profile of increased concentration of small, dense LDL particles (d: > 1.044 g/ml) and reduced HDL2a cholesterol than those with a VO2max >50 ml/kg/min. Multivariate regression analysis revealed that concentrations of small, dense LDL particles were primarily determined by BMI whereas HDL2a cholesterol and apolipoprotein A-I were primarily determined by physical fitness. These findings underline the relationship between a good physical fitness, a low body weight, and a favourable lipoprotein subfraction profile even in a healthy young male population.
COMPUTATIONAL FLUID DYNAMICS SIMULATION OF THE THERMAL UNIFORMITY IN CATALYTIC MICRO-COMBUSTORS

The combustion and heat transfer characteristics of hydrogen-air or methane-air mixtures in catalytic micro-combustors were studied numerically to assess the impact of wall thermal properties and key operation parameters on the thermal uniformity. A two-dimensional computational fluid dynamics (CFD) model was developed with detailed hetero-/homogeneous chemistry, heat conduction within the solid wall, surface radiation heat transfer, and external heat losses. Parametric studies were carried out to investigate the effect of wall thermal conductivity, feed composition, and flow rate on the thermal uniformity during highly exothermic catalytic reactions. Comparisons of hydrogenwith methane-air systems were made. Based on these insights, an overall energy balance analysis was performed in terms of enthalpy loss. It was shown that the wall thermal properties strongly affect the thermal uniformity, but little impact on the extinction limit and conversion. The feed composition and flow rate have a significant impact on the operating temperature, but only a moderate effect on the thermal uniformity. Most of the enthalpy released by the exothermic reaction is lost to the surroundings under certain conditions, although this energy exchange becomes less efficient as the flow rate increases. This feature is beneficial for heat-exchanger applications.
Gender and Minor Psychiatric Morbidity: Results of a Case-Control Study in a Developing Country

Objective: Women suffer from minor psychiatric disorders (MPM) more frequently than men. Most of the studies were conducted in England and in the United States and some reported the higher occurrence of MPM among women to be modified by marital status and others by sociodemographic variables. The present study intends to address this question in a developing country. Method: A population based case-control study was conducted in three important urban centers in Brazil. Two hundred seventy-six individuals diagnosed as new cases of MPM and 261 controls were selected to investigate the role of a set of sociodemographic variables in the association between gender and MPM using logistic regression models. Results: Univariate analysis showed that women were more likely than men to suffer from MPM (OR = 3.34; 2.27–4.91). After controlling for other sociodemographic variables, female gender was still positively associated with MPM, but not in a homogeneous way. A multiplicative interaction of gender with age group was found (LRT = 6.01; 2 df; p = 0.05) suggesting an increment in the magnitude of the association among those older than thirty years. Odds-ratios were 2.33 (1.19–4.55), 6.85 (2.86–16.41), and 7.47 (2.90–19.22) for age groups of fourteen to twenty-nine; thirty to forty-four; forty-five or more, respectively. There was no evidence of interaction of gender with marital status or other sociodemographic variables. Conclusions: The findings are consistent with the modification of the association between gender and MPM being mediated by social factors.
Electrical characterization of anomalous cells in phase change memory arrays

In order to integrate phase change memory (PCM) devices into large and yielding arrays, a programming window between the two memory logic states must exist with a probability of error less than 10-9 (1 PPB). Understanding and removing the mechanisms of cell failure during the programming operation is therefore required for this technology to be viable. This paper discusses new methodologies for PCM failure electrical characterization, discovers two potential failure mechanisms and proposes new approaches for improvements
Aerobic kinetoplastid flagellate Phytomonas does not require heme for viability

Heme is an iron-coordinated porphyrin that is universally essential as a protein cofactor for fundamental cellular processes, such as electron transport in the respiratory chain, oxidative stress response, or redox reactions in various metabolic pathways. Parasitic kinetoplastid flagellates represent a rare example of organisms that depend on oxidative metabolism but are heme auxotrophs. Here, we show that heme is fully dispensable for the survival of Phytomonas serpens, a plant parasite. Seeking to understand the metabolism of this heme-free eukaryote, we searched for heme-containing proteins in its de novo sequenced genome and examined several cellular processes for which heme has so far been considered indispensable. We found that P. serpens lacks most of the known hemoproteins and does not require heme for electron transport in the respiratory chain, protection against oxidative stress, or desaturation of fatty acids. Although heme is still required for the synthesis of ergosterol, its precursor, lanosterol, is instead incorporated into the membranes of P. serpens grown in the absence of heme. In conclusion, P. serpens is a flagellate with unique metabolic adaptations that allow it to bypass all requirements for heme.
Quantitation of hepatitis C virus in liver and peripheral blood mononuclear cells from patients with chronic hepatitis C virus infection

Since the natural history of hepatitis C virus‐associated liver disease and the therapeutic responsiveness might vary according to liver and blood mononuclear cells viral levels, it may be important to quantitate viral RNA in liver, blood mononuclear cells and serum, and to compare these data with genotype, biochemical and histologic data. A polymerase chain reaction‐based assay available for serum hepatitis C virus RNA quantitation has been optimized to quantitate viral genomes in liver and peripheral blood mononuclear cells from 47 chronic hepatitis C patients. The procedure permitted hepatitis C virus RNA quantitation in freshly isolated mononuclear cells and in total RNA extracted from frozen mononuclear cells and liver tissue. The intrahepatic viral amount (median: 2.6 × 103 copies/μg RNA; range: 0 to 3.6 × 104 copies/μg RNA) correlated significantly with the hepatitis C virus RNA concentration in serum (r = 0.76, P < .001) but not in mononuclear cells. Viral RNA concentrations in liver (P < .001), serum (P < 0.01) and PBMC (P < 0.05) were significantly higher in hepatitis C virus genotype 1 patients (essentially type 1b) than in non‐1 type cases, but were unrelated to biochemical or histologic indexes of disease activity. In conclusion, the optimized assay permit HCV RNA quantitation in liver and peripheral blood mononuclear cells, suggesting that serum viral level is an accurate measurement of intrahepatic viral burden. J. Med. Virol. 54:265–270, 1998. © 1998 Wiley‐Liss, Inc.
Optimal control of second‐order and high‐order descriptor systems

This study investigates the optimal control problem of second‐order descriptor systems. The optimal control is characterized by using a new second‐order generalized Riccati equation, which is directly derived in terms of the original coefficient matrices of the system. Under some assumption conditions, applying matrix's singular value decomposition and matrix transformation, a nonlinear generalized Riccati matrix equation is transformed into a linear matrix equation, and the optimal control gain can be determined by solving the linear matrix equation. Furthermore, relevant results are also extended to the optimal control problems for the high‐order descriptor system. Finally, several simulation examples and the comparison with the existing linearization method are provided to illustrate the effectiveness of the developed approach.
The Neural Basis of the Deficit Syndrome of Schizophrenia

The deficit syndrome is a domain of schizophrenic psychopathology defined by the presence of primary negative symptoms that are enduring features of a patient's function between periods of relapse. Lesions of the putative neural circuit underlying social affiliation and social behavioral cues in nonhuman primates and other mammals cause behavioral impairments in animals that model the diminished social drive, poverty of speech, and blunted affect of the deficit syndrome. Components of this circuit include the amygdala, periamygdalar cortex, and part of the prefrontal cortex. Abnormal function of this functional circuit may underlie the deficit syndrome.