Miracle-dz/UniFAR-FTUs huggingface dataset:
Analyst Interest as an Early Indicator of Firm Fundamental Changes and Stock Returns

ABSTRACT: We posit that a change in analyst interest in a firm is an early indicator of the firm's future fundamentals, capital market activities, and stock returns. We measure increases in analyst interest by obser.ving analysts who do not cover a firm but participate in that firm's earnings conference call, and we measure decreases in analyst interest by observing analysts who cover a firm, yet are absent from that firm's call. We find that increases in analyst interest are positively associated with future changes in firm fundamentals and capital market activities, while decreases in analyst interest are negatively associated with capital market activities. We also find that increases (decreases) in analyst interest are positively (negatively) correlated with future stock returns over the next three months and that a hedge portfolio yields a significant abnormal return. Overall, our study shows that analyst interest is a novel and early indicator of future firm fundamentals and capital market consequen.
The influence of blood sample storage time on the propofol concentration in plasma and solid blood elements.

In order to describe the changes of propofol concentration in whole blood and in its components during the blood storage we examined venous blood samples collected from patients anaesthetized either with or without propofol. Blood samples from patients anaesthetized without propofol were spike with propofol 45 min before analysis. Propofol concentration was examined in whole blood, plasma, rinsed formed elements and rinsed and lysed formed blood elements by means of HPLC after 1, 4, 7, 13, 21, 25 and 28 days of storage. There was significant decrease in plasma concentration of propofol during the first few days of sample storage followed by its increase during subsequent days. The opposite phenomenon was observed for formed blood elements. The findings support the hypothesis that propofol distribution between blood components changes in time.
The Research Unit of the Servizio di Psicologia Medica at the Institute of Psychiatry of the University of Verona, 1980–1991

Synopsis There has been an adult psychiatry research group within the Institute of Psychiatry of the University of Verona since 1970. However, in 1980, the University of Verona established a Chair in Medical Psychology and since that time a separate department gradually developed. This department, primarily devoted to epidemiological studies in mental health and to teaching activities, was later involved also in clinical work and was officially recognized by the Regional Health Department and by the Local Socio Health authorities (ULSS No. 25, Verona), as Servizio di Psicologia Medica. They provided additional financial support and new infrastructures not only for its clinical activities but also for research carried out in its Research Unit.
Distribution and ecology of the mayflies (Ephemeroptera) of Flanders (Belgium)

A literature survey and the identification of all available collection material resulted in a checklist and distribution maps for the mayflies occurring in Flanders. In addition, the relationship between the occurrence of mayflies and water characteristics was analysed. Of the 32 species that have been recorded, six are now extinct in Flanders (three of which are potamal species), while the majority of the remaining species are rare and their populations are often strongly isolated and therefore extremely vulnerable. Waters with relatively low oxygen levels and high conductivities were characterized by the most tolerant mayfly species Cloeon dipterum and Caenis robusta. However, most other species only occurred at higher oxygen concentrations and lower conductivities and could be separated into two groups. The first group mainly occurred in waters with a high pH and were often restricted to the loamy region or to stagnant waters, while the second group occurred in waters with a lower pH and mainly occurred in the Campine region. For most mayfly species, sustainable populations can only be achieved when their current habitats are adequately protected and, in addition, measures should be taken to connect and enlarge the remaining populations.
Adherence to Symptom-Based Care Guidelines for Down Syndrome

To assess adherence to symptom-based studies recommended in the health supervision guidelines for Down syndrome from the American Academy of Pediatrics (AAP), 24 pediatric care sites participated in retrospective chart review. Symptom-based screening and 4 associated recommendations, including cervical spine radiograph, video swallow study, celiac study with tissue transglutaminase and sleep study were analyzed by reviewing well-child visit notes of 264 children with Down syndrome. Given trends toward symptom-based screens, Pearson’s chi-square test and Fisher’s exact test were used to determine the association between symptom presence and receiving corresponding symptom-based screens. Adherence rates were widely variable ranging from 0% to 79% completion. Symptom-based studies were performed in 22% to 36% of patients. Symptom screens were documented positive in many patients, but the presence of symptoms did not correlate with completion of symptom-based screens. Symptom-based screening is low; associated studies were performed in patients without documented symptoms contrary to AAP recommendation.
Hypoxia and N6,O2'-dibutyryladenosine 3',5'-cyclic monophosphate, but not nerve growth factor, induce Na+ channels and hypertrophy in chromaffin-like arterial chemoreceptors.

Chronic hypoxia sensitizes the ventilatory reflex in mammals and causes enlargement of the carotid body, a peripheral arterial chemosensory organ. To investigate possible underlying mechanisms, in the absence of circulatory changes, we exposed cultures of dissociated rat carotid body containing the oxygen sensors (i.e., chromaffin-like glomus cells) to chronic hypoxia (6% O2) over a period of 2 weeks. After a delay of a few days, the Na+ current density in hypoxia-treated glomus cells increased significantly, reaching values up to 6 times that seen in normoxic (20% O2) controls. In addition the whole-cell capacitance, an indicator of cell size, was also significantly larger (3-4 times control) in glomus cells exposed to chronic hypoxia. Both effects were mimicked qualitatively by chronic treatment of normoxic cultures with N6,O2'-dibutyryladenosine 3',5'-cyclic monophosphate, but not nerve growth factor, which is known to induce similar changes in the chromaffin cell line PC12. Thus, the physiological and morphological effects of chronic hypoxia on the carotid body in vivo may be due in part to a cAMP-mediated stimulation of Na+ channel expression and hypertrophy in the chemosensory glomus cells.
rapid communication Muc 1 mucins on the cell surface are adhesion sites for Pseudomonas aeruginosa

Lillehoj, E. P., S. W. Hyun, B. T. Kim, X. G. Zhang, D. I. Lee, S. Rowland, and K. C. Kim. Muc1 mucins on the cell surface are adhesion sites for Pseudomonas aeruginosa. Am J Physiol Lung Cell Mol Physiol 280: L181–L187, 2001. — Recently, we cloned and characterized a full-length cDNA of the hamster Muc1 gene, the expression of which appears to be associated with secretory cell differentiation (Park HR, Hyun SW, and Kim KC. Am J Respir Cell Mol Biol 15: 237–244, 1996). The role of Muc1 mucins in the airway, however, is unknown. In this study, we investigated whether cell surface mucins are adhesion sites for Pseudomonas aeruginosa. Chinese hamster ovary (CHO) cells not normally expressing Muc1 mucin were stably transfected with the hamster Muc1 cDNA, and binding to P. aeruginosa was examined. Our results showed that 1) stably transfected CHO cells expressed both Muc1 mRNA and Muc1 mucins based on Northern and Western blot analyses, 2) Muc1 mucins present on the cell surface were degraded by neutrophil elastase, and 3) expression of Muc1 mucins on the cell surface resulted in a significant increase in adhesion of P. aeruginosa that was completely abolished by either proteolytic cleavage with neutrophil elastase or deletion of the extracellular domain by mutation. We conclude that Muc1 mucins expressed on the surface of CHO cells serve as adhesion sites for P. aeruginosa, suggesting a possible role for these glycoproteins in the early stage of airway infection and providing a model system for studying epithelial cell responses to bacterial adhesion that leads to airway inflammation in general and cystic fibrosis in particular.
Decreased and dysfunctional circulating endothelial progenitor cells in patients with chronic obstructive pulmonary disease

Background It has been widely demonstrated that endothelial progenitor cells are involved in several diseases and that they have therapeutic implications. In order to define the altered pulmonary vascular homeostasis in chronic obstructive pulmonary disease, we sought to observe the level and functions of circulating endothelial progenitor cells in patients with chronic obstructive pulmonary disease. Methods The total study population included 20 patients with chronic obstructive pulmonary disease and 20 control subjects. The number of circulating endothelial progenitor cells (CD34+/CD133+/VEGFR‐2+ cells) was counted by flow cytometry. Circulating endothelial progenitor cells were also cultured in vitro and characterized by uptake of DiIacLDL, combining with UEA‐I, and expression of von Willebrand factor and endothelial nitric oxide synthase. Adhesion, proliferation, production of nitric oxide, and expression of endothelial nitric oxide synthase and phosphorylated‐endothelial nitric oxide synthase were detected to determine functions of circulating endothelial progenitor cells in patients with chronic obstructive pulmonary disease. Results The number of circulating endothelial progenitor cells in the chronic obstructive pulmonary disease group was lower than in the control group: (0.54±0.16)% vs. (1.15±0.57)%, P <0.05. About 80% of adherent peripheral blood mononuclear cells cultured in vitro were double labeled with Dil‐acLDL and UEA‐1. The 92% and 91% of them were positive for von Willebrand factor and endothelial nitric oxide synthase, respectively. Compared with the control, there were significantly fewer adhering endothelial progenitor cells in chronic obstructive pulmonary disease patients: 18.7±4.8/field vs. 45.0±5.9/field, P <0.05. The proliferation assay showed that the proliferative capacity of circulating endothelial progenitor cells from chronic obstructive pulmonary disease patients was significantly impaired: 0.135±0.038 vs. 0.224±0.042, P <0.05. Furthermore, nitric oxide synthase (112.06±10.00 vs. 135.41±5.38, P <0.05), phosphorylated endothelial nitric oxide synthase protein expression (88.89±4.98 vs. 117.98±16.49, P <0.05) and nitric oxide production ((25.11±5.27) &mgr;mol/L vs. (37.72±7.10) &mgr;mol/L, P <0.05) were remarkably lower in endothelial cells from the chronic obstructive pulmonary disease group than the control. Conclusion Circulating endothelial progenitor cells were decreased and functionally impaired in patients with chronic obstructive pulmonary disease.
45nm Gateless Anti-Fuse Cell with CMOS Fully Compatible Process

A new gateless anti-fuse cell with 45 nm CMOS fully compatible process has been developed for advanced programmable logic applications. This gateless anti-fuse cell processed by pure logic process and decoupled with logic gate oxide has a highly stable and five orders of on/off current window. It also exhibits superior program performance by only 5 V operation with no more than 10 muA programming current. This new nitride gateless anti-fuse cell is a very promising logic OTP solution with fully CMOS compatible process below 90 nm node.
Effective theory approach to brane world black holes

We derive static spherically symmetric vacuum solutions of the low-energy effective action for the two brane Randall-Sundrum model. The solutions with nontrivial radion belong to a one-parameter family describing traversable wormholes between the branes and a black hole, and were first discovered in the context of Einstein gravity with a conformally coupled scalar field. From a brane world perspective, a distinctive feature of all the solutions with nontrivial radion is a brane intersection about which the bulk geometry is conical but the induced metrics on the branes are regular. Contrary to earlier claims in the literature, we show these solutions are stable under monopole perturbations.
Erythema dyschromicum perstans: the continuing enigma of Cinderella or ashy dermatosis

, 230–232 © 2004 The International Society of Dermatology 230 Erythema dyschromicum perstans (EDP) (ashy dermatosis) is a distinct and somewhat controversial cutaneous eruption closely linked with lichen planus (LP) since its original description by Ramirez 1 in El Salvador in 1957. 2–9 It is most common in Latin America and Asia, somewhat more frequent in women than in men, and has no apparent age preference; however, it is seen worldwide, including in individuals in or originating from northern and western Europe. 9–11 Bahadir et al . 12 described a 16-year-old Turkish boy whose eruption was notable both for its occurrence in a Turk and for its successful response to dapsone.
Bone marrow pre‐B lymphocytes synthesize immunoglobulin mu chains of membrane type with different properties and intracellular pathways.

Mouse normal bone marrow pre‐B lymphocytes synthesize only membrane mu chains (micron), as shown by mRNA studies and peptide analysis. The micron chains exist in two forms: free micron chains assembled into dimers, or L chain‐bound micron chains present in IgM monomers (in the case of ‘late pre‐B cells’, i.e., after productive L chain gene rearrangement). These two forms of molecules are very different in properties, fate and intracellular pathways. Free but not L chain‐bound mu chains are highly susceptible to mild proteolysis, which degrades their entire Cmu 1 and VH domains. Free mu chains are rapidly degraded within the lysosomal compartment, which they reach via the cis, avoiding the trans, part of the Golgi complex. In contrast, as soon as mu chains bind to L chains, they are directed towards the ‘trans’ Golgi compartment, where they undergo terminal glycosylation, then to the cell surface, where they progressively accumulate. It is suggested that the conformation instability of the Cmu 1 and VH domains of the free mu chains plays a critical role in the intracellular targeting of these molecules, as compared with that of L chain‐bound mu chains.
Group X Secreted Phospholipase A2 Releases ω3 Polyunsaturated Fatty Acids, Suppresses Colitis, and Promotes Sperm Fertility*

Within the secreted phospholipase A2 (sPLA2) family, group X sPLA2 (sPLA2-X) has the highest capacity to hydrolyze cellular membranes and has long been thought to promote inflammation by releasing arachidonic acid, a precursor of pro-inflammatory eicosanoids. Unexpectedly, we found that transgenic mice globally overexpressing human sPLA2-X (PLA2G10-Tg) displayed striking immunosuppressive and lean phenotypes with lymphopenia and increased M2-like macrophages, accompanied by marked elevation of free ω3 polyunsaturated fatty acids (PUFAs) and their metabolites. Studies using Pla2g10-deficient mice revealed that endogenous sPLA2-X, which is highly expressed in the colon epithelium and spermatozoa, mobilized ω3 PUFAs or their metabolites to protect against dextran sulfate-induced colitis and to promote fertilization, respectively. In colitis, sPLA2-X deficiency increased colorectal expression of Th17 cytokines, and ω3 PUFAs attenuated their production by lamina propria cells partly through the fatty acid receptor GPR120. In comparison, cytosolic phospholipase A2 (cPLA2α) protects from colitis by mobilizing ω6 arachidonic acid metabolites, including prostaglandin E2. Thus, our results underscore a previously unrecognized role of sPLA2-X as an ω3 PUFA mobilizer in vivo, segregated mobilization of ω3 and ω6 PUFA metabolites by sPLA2-X and cPLA2α, respectively, in protection against colitis, and the novel role of a particular sPLA2-X-driven PUFA in fertilization.
COMPARISON OF MILLIMETER-WAVE AND X-RAY EMISSION IN SEYFERT GALAXIES

We compare the emission at multiple wavelengths of an extended Seyfert galaxy sample, including both types of Seyfert nuclei. We use the Caltech Submillimeter Observatory to observe the CO J = 2–1 transition line in a sample of 45 Seyfert galaxies and detect 35 of them. The galaxies are selected by their joint soft X-ray (0.1–2.4 keV) and far-infrared (λ = 60–100 μm) emission from the ROSAT/IRAS sample. Since the CO line widths (WCO) reflect the orbital motion in the gravitational potential of the host galaxy, we study how the kinematics are affected by the central massive black hole (BH), using the X-ray luminosity. A significant correlation is found between the CO line width and hard (0.3–8 keV from Chandra and XMM-Newton) X-ray luminosity for both types of Seyfert nuclei. Assuming an Eddington accretion to estimate the BH mass (MBH) from the X-ray luminosity, the WCO–LX relation establishes a direct connection between the kinematics of the molecular gas of the host galaxy and the nuclear activity, and corroborates the previous studies that show that the CO is a good surrogate for the bulge mass. We also find a tight correlation between the (soft and hard) X-ray and the CO luminosities for both Seyfert types. These results indicate a direct relation between the molecular gas (i.e., star formation activity) of the host galaxy and the nuclear activity. To establish a clear causal connection between molecular gas and the fueling of nuclear activity, high-resolution maps (<100 pc) of the CO emission of our sample will be required and provided in a forthcoming Atacama Large Millimeter Array observation.
FP//LINSPACE computability of real Riemann zeta function in Ko-Friedman model

In the present paper, we construct an algorithm for the evaluation of real Riemann zeta function $\zeta(s)$ for all real $s$, $s>1$, in polynomial time and linear space on Turing machines in Ko-Friedman model. The algorithms is based on a series expansion of real Riemann zeta function $\zeta(s)$ (the series globally convergents) and uses algorithms for the evaluation of real function $(1+x)^h$ and hypergeometric series in polynomial time and linear space. The algorithm from the present paper modified in an obvious way to work with the complex numbers can be used to evaluate complex Riemann zeta function $\zeta(s)$ for $s=\sigma+\mathbf{i}t$, $\sigma\ne 1$ (so, also for the case of $\sigma<1$), in polynomial time and linear space in $n$ wherein $2^{-n}$ is a precision of the computation; the modified algorithm will be also polynomial time and linear space in $\lceil \log_2(t)\rceil$ and exponential time and exponential space in $\lceil \log_2(\sigma)\rceil$.
Efficacy of amoxicillin and metronidazole combination for the management of generalized aggressive periodontitis.

BACKGROUND The aim of this study is to evaluate the effects of metronidazole-amoxicillin combination on clinical and microbiologic parameters in patients with generalized aggressive periodontitis. METHODS Twenty-eight patients were randomly included. The test group (n = 12) received amoxicillin-metronidazole combination and scaling and root planing; the control group (n = 16) received scaling and root planing alone. In addition to the clinical examinations, subgingival plaque samples were analyzed for total cultivable bacteria and the presence of Porphyromonas gingivalis, Tannerella forsythia (previously T. forsythensis), Treponema denticola, Prevotella intermedia, Prevotella nigrescens, Prevotella pallens, and Aggregatibacter actinomycetemcomitans (previously Actinobacillus actinomycetemcomitans) using polymerase chain reaction. RESULTS All clinical parameters improved significantly compared to baseline (P <0.05) in both groups. There was a statistically significant reduction of pockets and clinical attachment gain in the combined group compared to the control group (P <0.05). Total counts of bacteria also decreased significantly at 3 and 6 months in both groups (P <0.05). T. denticola and T. forsythia were the most prevalent bacteria throughout the study. T. denticola showed a continuous decrease over 6 months in the test group, whereas no change was seen in the control group beyond 3 months. P. gingivalis decreased significantly at 3 months (P <0.05), whereas T. forsythia was the only pathogen decreased below detection limits by the combination therapy with a significant difference compared to the control group (P <0.05). CONCLUSIONS The results from this study suggest that combined amoxicillin and metronidazole use as an adjunct to scaling and root planing leads to better clinical healing compared to mechanical treatment alone. The polypharmaceutical approach used results in a significant and substantial decrease in T. forsythia and prevents its recolonization for 6 months, suggesting that T. forsythia may determine the long-term stability of periodontal treatment outcomes.
Increased expression of nitric oxide synthase and dendritic injury in simian immunodeficiency virus encephalitis.

OBJECTIVES Widespread dendritic injury may be one mechanism involved in the neurologic impairment that occurs in HIV-1 infection. The objectives of this study were to quantitate the extent of dendritic injury in a primate model of central nervous system (CNS) infection, investigate the role of nitric oxide (NO) as a mediator of neuropathologic changes, and evaluate the relation of these changes to cognitive and motor function. STUDY DESIGN/METHODS Cognitive and motor function was assessed in rhesus macaque monkeys infected with simian immunodeficiency virus (SIV). In situ hybridization, immunohistochemistry, and quantitative image analysis were employed to assess the relations among productive infection, NO synthase (iNOS), and dendritic injury. RESULTS Productive infection of cells of the macrophage lineage in CNS is associated with inflammation, increased expression of iNOS, and dendritic injury. The tests of cognitive and motor function employed were abnormal in both animals that had evidence of productive infection and those that did not. CONCLUSIONS Increased NO accompanying productive infection and encephalitis may be one cause of neuronal injury in lentivirus infections of the CNS. Extension of tests of cognitive and motor function to late-stage AIDS in rhesus monkeys is needed to assess the potential role of NO-induced dendritic damage in lentiviral encephalopathy/AIDS dementia complex.