Miracle-dz/UniFAR-FTUs huggingface dataset:
Prediction of IDH Status Through MRI Features and Enlightened Reflection on the Delineation of Target Volume in Low-Grade Gliomas

Isocitrate dehydrogenase mutational status defines distinct biologic behavior and clinical outcomes in low-grade gliomas. We sought to determine magnetic resonance imaging characteristics associated with isocitrate dehydrogenase mutational status to evaluate the predictive roles of magnetic resonance imaging features in isocitrate dehydrogenase mutational status and therefore their potential impact on the determination of clinical target volume in radiotherapy. Forty-eight isocitrate dehydrogenase-mutant and 28 isocitrate dehydrogenase–wild-type low-grade gliomas were studied. Isocitrate dehydrogenase mutation was related to more frequency of cortical involvement compared to isocitrate dehydrogenase–wild-type group (34/46 vs 6/24, P = .0001). Peritumoral edema was less frequent in isocitrate dehydrogenase–mutant tumors (32.6% vs 58.3% for isocitrate dehydrogenase–wild-type tumors, P = .0381). Isocitrate dehydrogenase–wild-type tumors were more likely to have a nondefinable border, while isocitrate dehydrogenase–mutant tumors had well-defined borders (66.7% vs 39.1%, P = .0287). Only 8 (17.4%) of 46 of the isocitrate dehydrogenase–mutant tumors demonstrated marked enhancement, while this was 66.7% in isocitrate–wild-type tumors (P < .0001). Choline–creatinine ratio for isocitrate dehydrogenase–wild-type tumors was significantly higher than that for isocitrate dehydrogenase–mutant tumors. In conclusion, frontal location, well-defined border, cortical involvement, less peritumoral edema, lack of enhancement, and low choline–creatinine ratio were predictive for the definition of isocitrate dehydrogenase–mutant low-grade gliomas. Magnetic resonance imaging can provide an advantage in the detection of isocitrate dehydrogenase status indirectly and indicate the need to explore new design for treatment planning in gliomas. Choline–creatinine ratio in magnetic resonance spectroscopy could be a potential more reasonable reference for the new design of delineation of target volume in low-grade gliomas.
R-carvedilol, a potential new therapy for Alzheimer’s disease

For decades, the amyloid cascade hypothesis has been the leading hypothesis in studying Alzheimer’s disease (AD) pathology and drug development. However, a growing body of evidence indicates that simply removing amyloid plaques may not significantly affect AD progression. Alternatively, it has been proposed that AD progression is driven by increased neuronal excitability. Consistent with this alternative hypothesis, recent studies showed that pharmacologically limiting ryanodine receptor 2 (RyR2) open time with the R-carvedilol enantiomer prevented and reversed neuronal hyperactivity, memory impairment, and neuron loss in AD mouse models without affecting the accumulation of ß-amyloid (Aβ). These data indicate that R-carvedilol could be a potential new therapy for AD.
Salivary oxytocin in autistic patients and in patients with intellectual disability

Background Assessing the role of oxytocin (OT) in the regulation of social interaction is a promising area that opens up new opportunities for studying the mechanisms of developing autism spectrum disorders (ASD). Aim To assess the correlation between the salivary OT level and age-related and psychopathological symptoms of children with intellectual disability (ID) and ASD. Methods We used the clinical and psychopathological method to assess the signs of ASD based on International Classification of Diseases (ICD-10), the severity of ASD was specified by the selected Russian type version “Childhood Autism Rating Scale” (CARS). Patients of both groups had an IQ score below 70 points. Results The median and interquartile range of salivary OT levels in patients with ID and ASD were 23.897 [14.260–59.643] pg/mL, and in the group ID without ASD - Me = 50.896 [33.502–83.774] pg/mL (p = 0.001). The severity of ASD on the CARS scale Me = 51.5 [40.75–56.0] score in the group ID with ASD, and in the group ID without ASD—at the level of Me = 32 [27.0–38.0] points (p < 0.001). According to the results of correlation-regression analysis in the main group, a direct correlation was established between salivary OT level and a high degree of severity of ASD Rho = 0.435 (p = 0.005). There was no correlation between the salivary OT level and intellectual development in the group ID with ASD, Rho = 0.013 (p = 0.941) and we have found a relationship between oxytocin and intellectual development in the group ID without ASD, Rho = 0.297 (p = 0.005). There was no correlation between salivary OT and age, ASD and age. Conclusion The results of this study indicate that patients in the group ID with ASD demonstrated a lower level of salivary OT concentration and a direct relationship between the maximum values of this indicator and the severity of autistic disorders, in contrast to patients in the group ID without ASD.
Survei Gambaran Pengetahuan dan Pola Swamedikasi Jerawat pada Mahasiswa FMIPA Universitas Islam Bandung

Abstract. Acne is one of skin disease that can lower one’s confidence. Most students treat acne with self-medication. Knowledge of acne and its self-medication will affect the success of the therapy. This study aims to describe the knowledge of acne and its self-medication, also to know the acne’s self-medication pattern such as non-pharmacological therapy, pharmacological therapy, and the success of self-medication therapy. This study is a descriptive non-experimental study with a cross-sectional approach. Data were taken using a questionnaire that had been through a pretest test. The sample were 93 students from FMIPA Unisba who fulfilled the inclusion criteria. Results show that the knowledge of health faculty students (94,34%) was better than the non-health faculty students (60,00%) in knowing pharmacological therapy with a single active substance.The knowledge of non-health faculty students (77,50%) was better than health faculty students (69,38%) in knowing the impact of acne. Self-medication pattern which was prevention by washing face twice a day (67.03%), acne treatment with sulfur active substances (27.273%) combination of sulfur and salicylic acid (21.739%). Clinical outcome tended to be good on health faculty students and the non-health faculty students (54,72%) and (52,50%) respectively success on therapy. Keywords: Knowledge, Self-Medication Pattern, Acne vulgaris . Abstrak. Jerawat merupakan salah satu penyakit kulit yang dapat menurunkan rasa percaya diri seseorang. Sebagian besar mahasiswa mengobati jerawat secara swamedikasi. Pengetahuan mengenai jerawat dan swamedikasi jerawat ini akan berpengaruh terhadap keberhasilan terapi yang dilakukan. Penelitian ini bertujuan untuk mengetahui gambaran pengetahuan yang mencakup jerawat dan swamedikasi jerawat serta pola swamedikasi jerawat yang meliputi terapi non farmakologi, terapi farmakologi, sumber informasi obat, dan keberhasilan terapi secara swamedikasi. Penelitian ini merupakan penelitian non eksperimental yang bersifat deskriptif dengan pendekatan cross sectional. Data diambil menggunakan kuesioner yang telah melalui uji pretest. Sampel yang digunakan sebanyak 93 orang dari mahasiswa FMIPA Unisba yang memenuhi kriteria inklusi. Hasil menunjukan bahwa pengetahuan mahasiswa kesehatan (94,34%) lebih baik daripada non kesehatan (60,00%) dalam mengetahui terapi farmakologi dengan zat aktif tunggal. Pengetahuan mahasiswa non kesehatan (77,50%) lebih baik daripada mahasiswa kesehatan (69,38%) dalam mengetahui dampak dari jerawat . Pola swamedikasi berupa pencegahan dengan frekuensi mencuci muka sebanyak dua kali sehari (67,03%), pengobatan jerawat dengan zat aktif sulfur (27,27%), dan kombinasi sulfur dengan asam salisilat (21,74%). Keberhasilan terapi cenderung baik pada mahasiswa kesehatan dan non kesehatan masing masing (54,72%) dan (52,50%) berhasil. Kata Kunci: Pengetahuan, Pola Swamedikasi dan Jerawat.
Sentiment-Apt Investors and UK Sector Returns

This paper examines the relationship between sentiment-apt investors and UK stock returns at industry level over the period January 1988 to December 2017. Using two new sentiment proxies (laggards to leaders and growth opportunity index) for ten discrete sector groupings, we provide novel evidence on how returns in the UK stock market react to the activities of sentiment-disposed investors. First, using threshold nonlinear regression, we document a significant relationship between the laggards to leaders sentiment proxy and sectoral returns. Our findings reveal that aggregate returns in the sector are affected by activities of investors who embark on profit-taking when there is an increase in the proportion of lagging to leading stocks beyond the threshold value. Secondly, when using the growth opportunity sentiment proxy, we report that the increase in growth above the growth threshold value has a significant impact on sector returns. This study further confirms significant impact of non-threshold variables on sector groupings. Our findings are robust, having been subjected to a range of robustness checks.
Health status of adults after bacterial and fungal bloodstream infections

Bacterial and fungal bloodstream infections are life-threatening diseases. Risk factors for their acquisition are well described. They carry high early mortality and may be community or hospital-acquired. Many studies document this early mortality but considerable debate remains about the relative importance of underlying disease severity and acute sepsis when evaluating probability for early death. Longer term mortality is not well understood with very few studies assessing quality of survival. A prospective longitudinal cohort study aimed to improve knowledge about mortality and health status of survivors of these infections. The study question asked: for adults who have had bacterial or fungal bloodstream infections what are the risks for and patterns of • early and late mortality; and • delayed recovery and reduced health status in survivors? The study population comprised all patients at a tertiary referral and teaching hospital providing speciality services for a regional catchment of 500,000. For three years, all patients over 16 years old with significant (blood culture positive) bacterial or fungal bloodstream infections were recruited, comprising the main cohort. In addition to baseline surveillance data, study information included pre-admission functional status, comorbidities, underlying severity of disease and antibiotic therapy initiated. For,the third year, those identified with infection were followed for an additional 25 weeks (a nested cohort). As well as documenting mortality, all survivors were assessed for reduced or full health status at one week, one month and six months. In addition, telephone interviews at one and six months, using the London Handicap Scale and the Sickness Impact Profile, provided self-assessed functional status for those able to participate. Exploratory statistical analysis identified that risk factors for mortality and for reduced health in survivors were not the same. Therefore, a separate analysis, using logistic regression, was conducted for the survivor cohort at each time point after risk factors for mortality had been identified. Over three years, 628 adults were followed for the first week of infection. There were more males than females and the median age at infection was 64.5 years. More infections were caused by Gram-positive than Gram-negative organisms with S aureus and E coli respectively being the most common isolates. Forty-one per cent of infections were inpatient acquired with an additional 17% being outpatient but health care related. Intravascular access devices were the most common primary infection sites. Before infection, 25% of adults had an active malignancy and one-tenth required a high level of assistance with activities of daily living.
Investigating the effect of synchronized movement on toddlers’ word learning

The effect of interpersonal behavioral synchrony on children’s behavior is an emerging field rich with research potential. While studies demonstrate its effect on affiliative and prosocial outcomes, the role of synchronized movement on children’s specific learning outcomes has not yet been investigated experimentally. One possibility is that synchrony, as a coordinated social activity, encourages perceived social bonds, leading to heightened attention, and better information retention. Equally likely is that physiological, rather than social learning, mechanisms mediate the effect, given the previously demonstrated role of autonomic arousal in attentional fluctuations, cognitive engagement, problem solving, exploration, and curiosity. The present study investigated the behavioral and physiological effects of synchrony conceptualized as induced, interpersonal, behavioral, movement-based interaction, on word learning in 2.5-year-old children. In a laboratory experiment, toddlers engaged in either a synchronous or an asynchronous movement-based interaction with an adult experimenter while listening to an upbeat children’s song. After the (a)synchronous movement episode, the same experimenter engaged children in a word learning task. During the (a)synchrony and learning phases, children’s physiological arousal was continuously recorded, resulting in heart rate and skin conductance response measures. Following a caregiver-child free play break, children were tested on their novel word retention. The results indicated that children learned novel labels at equal rates during the learning phase in both conditions, and their retention at test did not differ between conditions: although above chance retention of novel labels was found only following the synchronous, but not the asynchronous episode, the cross-episode comparisons did not reach statistical significance. Physiological arousal indices following the (a)synchrony episode did not differ between conditions and did not predict better word learning, although skin conductance response was higher during the learning than the movement episode. This study contributes to our understanding of the underlying cognitive and physiological mechanisms of interpersonal behavioral synchrony in the knowledge acquisition domain and paves the way to future investigations.
Economic issues of Hungarian table egg production in different housing systems, farm sizes and production levels

The aim of this study is to reveal the effects of housing systems, farm sizes and production levels on the economic indicators of Hungarian table egg production. This research is based on the farm-level cost and income data and the related weights of egg production farms between 2003-2015 from the Hungarian FADN database. These data were processed using descriptive statistics and correlation and regression analyses were performed to evaluate the correlations between each indicator. The results show that table egg can be more effectively produced using enriched cage system as opposed to barns. The unit cost of egg is lower in larger farm size, however, other factors also affect its value. The increase of production level is also in a positive correlation with the examined economic indicators.
Anesthesia management of open tracheostomy patients: A single center experience

The purpose of the present study of ours was to evaluate anesthesia management and complications in open technique tracheostomy cases. This study was conducted in 105 patients who underwent tracheostomy. The patients were retrospectively screened. The demographic data, anesthesia management, length of hospital stay, Intensive Care Unit stay, mortality, perioperative, postoperative, and early complications of the patients were evaluated. The average age of the patients was 20-91 (60±14.92) years. ASA scores were as follows: 54 cases (51.4%) were ASA II; 45 cases (42.8%) were ASA III; and 6 cases (5.7%) were ASA IV. The most common complaints of the patients were as follows: Head-neck tumor in 75 cases (71.4%). The anesthesia methods were as follows: General anesthesia in 92 cases (87.6%), and sedoanalgesia in 13 cases (12.4%). The most common complications were as follows: Bleeding in 5 patients (4.7%) in the perioperative period; and respiratory failure in 19 patients (18.1%) in the postoperative period. Postoperative mortality was seen in 6 cases (5.7%). There was a statistically significant difference between the mortality rates, hospital stay, and age (P: 0.008) (P<0.0001). In the present study of ours, it was shown that hospital stay and age factor had a significant effect on mortality in tracheostomy cases. We believe that sedoanalgesia, which preserves.
Differences in oxytocin and vasopressin levels in individuals suffering from the autism spectrum disorders vs general population – a systematic review

Introduction Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social interactions, communication, and the presence of stereotyped, repetitive behaviors. Oxytocin (OXT) and arginine-vasopressin are neuropeptides produced in hypothalamus and they are related to processing emotions and social behavior. In the light of a growing number of scientific reports related to this issue, the two neurohormones started to be linked with the basis of neurodevelopmental disorders, including the ASD. The aim of this study was a systematic review of previous studies regarding the differences in OXT and vasopressin levels in ASD and neurotypical persons. Materials and methods Literature review focused on publications in the last 10 years located via the MEDLINE/PubMed database as well as the Google Scholar browser. Selection was made by assumptive criteria of inclusion and exclusion. Results From the 487 studies qualified to the initial abstract analysis, 12 met the six inclusion criteria and were included in the full-text review. Conclusion Currently, available study reports still do not provide unequivocal answers as to the differences in concentrations of those neuropeptides between children with ASD and neurotypical control. Therefore, it is necessary to continue the research taking into account necessity of proper homogenization of study groups, utilization of objective and quantifiable tools for ASD diagnosis and broadening the range of biochemical and molecular factors analyzed.
Introduction of Auricular Acupuncture

The overall purpose of this quality improvement project was to assess if there was an interest to add auricular acupuncture to a substance abuse program. The two guiding questions of the Doctor of Nursing Project were (a) how can auricular acupuncture be helpful when treating patients with substance abuse in a selected organization? (b) what information is needed for both staff and patients to make an informed decision regarding auricular acupuncture? The Promoting Action on Research Implementation in Health Services (PARiHS) framework was used as the theory framework for implementation of evidence-based research into an organization. The facilitator in the PARiHS framework used the Adult Learning Theory when teaching the staff and patients about an implementation change in the selected organization. The Adult Learning Theory principles were applied during the facilitation of the presentation “Introduction of Auricular Acupuncture” to the staff and patients of the non-profit substance abuse agency located in an urban Midwestern city. The Adult Learning Theory was utilized to assess if there was an interest in implementing auricular acupuncture in the agency’s rehabilitation and detoxification programs. The outcome of the project had clarification for the DNP student and the organization that there is a significant level of interest in implementing and including auricular acupuncture in the patients’ treatment plan while the patient is going through detoxification or the rehabilitation process from illicit drugs or alcohol. Several staff members expressed interest to be trained to do the auricular acupuncture procedure. The cost of training the staff is the largest hurdle in a non-profit organization. Further investigation is needed to see if auricular acupuncture could be a billable item to insurance companies for reimbursement.
Bi-dimensional values and attitudes toward online fast food-buying intention during the COVID-19 pandemic: An application of VAB model

The purpose of the study is to determine the factors of online fast food-buying intention among Bangladeshi Millennials during the COVID-19 pandemic. The study adopted the Value-Attitude-Behavior (VAB) model and designed it as a higher-order constructs model to predict buying intention. Using a quantitative method (i.e., cross-sectional survey), data was collected from 325 respondents via a structured questionnaire and subsequently analyzed using Structural Equation Modeling (SEM) through AMOS software. The findings of the study revealed that convenience and food quality generate utilitarian values, while subjective norms and novelty-seeking form hedonic values. Also, utilitarian and hedonic values significantly affect cognitive and affective attitudes. As opposed to food quality, the cognitive attitude, affective attitude, self-identity, and subjective norms were observed to affect behavioral intention, with affective attitude producing the strongest association, albeit with the high explanatory power of the model. Consequently, this study offers a number of theoretical and policy implications to design better interventions that address public health regarding fast food consumption.
The effect of core self-evaluations on career adaptability: The mediating role of protean career attitudes and the moderating role of meritocratic beliefs

Based on the career construction model of adaptation, this study explores the impact of core self-evaluations on career adaptability, with the mediating role of protean career attitudes and moderating role of meritocratic beliefs. The results of the questionnaire survey on 1000 Chinese college students show that: (1) core self-evaluations positively predicted college students’ career adaptability; (2) protean career attitudes mediated the relationship between core self-evaluations and career adaptability; (3) meritocratic beliefs not only moderated the effect protean career attitudes have on career adaptability but also moderated the indirect influence of core self-evaluations on career adaptability through protean career attitudes. These results extend the existing antecedent studies on career adaptability and demonstrate the importance of combining self-mobility beliefs (protean career attitudes) with social mobility beliefs (meritocratic beliefs) in the process of core self-evaluations affecting career adaptability. In conclusion, we hope to further develop the theory of career construction and provide more suggestions for college consultants and students.