Miracle-dz/UniFAR-FTUs huggingface dataset:
Adaptive Moving Window Regression ( AMWR ) Predicted data Kafka Event Collector Complex Event Engine Event

The requirements of analyzing heterogeneous data streams and detecting complex patterns in near real-time have raised the prospect of Complex Event Processing (CEP) for many internet of things (IoT) applications. Although CEP provides a scalable and distributed solution for analyzing complex data streams on the fly, it is designed for reactive applications as CEP acts on near real-time data and does not exploit historical data. In this regard, we propose a proactive architecture which exploits historical data using machine learning (ML) for prediction in conjunction with CEP. We propose an adaptive prediction algorithm called Adaptive Moving Window Regression (AMWR) for dynamic IoT data and evaluated it using a real-world use case with an accuracy of over 96%. It can perform accurate predictions in near real-time due to reduced complexity and can work along CEP in our architecture. We implemented our proposed architecture using open source components which are optimized for big data applications and validated it on a use-case from Intelligent Transportation Systems (ITS). Our proposed architecture is reliable and can be used across different fields in order to predict complex events.
Utility of quantitative flow cytometry immunophenotypic analysis of CD5 expression in small B-cell neoplasms.

CONTEXT The value of assessing CD5 expression in the differential diagnosis of small B-cell neoplasms is well established. Assessment is usually done qualitatively. OBJECTIVES To assess CD5 expression levels by quantitative flow cytometry immunophenotyping and to determine possible differences among various small B-cell neoplasms. DESIGN We performed 4-color flow cytometry analysis on specimens of peripheral blood and bone marrow aspirate and quantified CD5 expression in various small B-cell lymphomas and leukemias. We also assessed CD5 levels in peripheral blood samples of healthy blood donors. RESULTS Cases of chronic lymphocytic leukemia and mantle cell lymphoma had higher levels of CD5 compared with control B cells (P < .001). Cases of marginal zone lymphoma and hairy cell leukemia had CD5 levels similar to control B cells (P = .35 and P = .14, respectively), whereas cases of follicular lymphoma and lymphoplasmacytic lymphoma had significantly lower CD5 levels than control B cells (P < .001 and P = .04, respectively). In B-cell neoplasms, a high level of CD5 expression was correlated with a homogeneous pattern of positive events, whereas lower CD5 levels were correlated with heterogeneous patterns of positive events. CONCLUSIONS Using flow cytometric immunophenotypic analysis to quantify CD5 levels can aid in diagnosis. CD5 expression levels are higher in patients with chronic lymphocytic leukemia and mantle cell lymphoma, and expression is observed in a homogeneous pattern, as compared with other B-cell neoplasms that are either negative for CD5 or express CD5 at lower levels with a heterogeneous pattern. However, there is some overlap in CD5 expression levels between a subset of atypical chronic lymphocytic leukemia and marginal zone lymphoma cases.
Maxillary midline diastemas: a look at the causes.

BACKGROUND Maxillary midline diastemas are a common esthetic problem that dentists must treat. Many innovative therapies have been used, varying from restorative procedures to surgery (frenectomies) and orthodontics. At times, these procedures have been performed by the dentist without full appreciation of the factors contributing to the diastemas. CASE DESCRIPTION Before the practitioner can determine the optimal treatment, he or she must consider the contributing factors. These include normal growth and development, tooth-size discrepancies, excessive incisor vertical overlap of different causes, mesiodistal and labiolingual incisor angulation, generalized spacing and pathological conditions. A carefully developed differential diagnosis allows the practitioner to choose the most effective orthodontic and/or restorative treatment. CLINICAL IMPLICATIONS The differential diagnosis leads to a treatment approach that most effectively addresses the patient's problem. By treating the cause of the diastema, rather than just the space, the dentist enhances both the patient's dental function and appearance.
Comparison of survival periods and response in three modes of treatment for Ca esophagus at CENAR Quetta.

BACKGROUND Esophageal cancer is a fatal disease, with mortality matching the incidence. Balochistan province and Afghanistan happen to fall in the "Esophageal Cancer Belt". This study was designed to compare survival periods and response in three different modes of treatment for cancer of esophagus at CENAR Quetta i.e Radiotherapy plus Surgery, Radiotherapy plus Surgery plus single agent chemotherapy and Radiotherapy plus Surgery plus combined chemotherapy. METHODS During 1997, 59 patients with histopathological evidence of Ca esophagus were referred to CENAR from primary health care centers in Balochistan and Afghanistan. These 59 patients were divided into three groups. Group:I (n=22) treated by local irradiation plus surgery. Group:II (n=20) treated by local irradiation plus surgery plus Single agent chemotherapy i.e 5 florouracil. Group:III (n=17) treated by local irradiation plus surgery plus combination chemotherapy i.e Cis-Platinum and 5-florouracil. All patients were evaluated by endoscopic examination at 2 month intervals. RESULTS This study of 59 patients (mean age 55+/-13 years and male to female ratio of 1:3), shows that 2 year survival is 29% and median survival period is 9 month for all the patients. For group I, median survival period = 5 month, 2 year survival = 18% and complete response = 17%. For group II, Median survival period = 9 months, 2 year survival = 30% and complete response = 20%. For group III, Median survival period = 11 month, 2 year survival = 41% and complete response = 22%. CONCLUSION This study shows that overall survival is poor in cancer of esophagus and combined chemotherapy along with surgery and radiotherapy gives better results as compared to other two groups. Also single agent chemotherapy plus surgery plus radiotherapy give better results than radiotherapy plus surgery.
Role of the GYVG Pore Motif of HslU ATPase in Protein Unfolding and Translocation for Degradation by HslV Peptidase*

HslVU is an ATP-dependent protease consisting of HslU ATPase and HslV peptidase. In an HslVU complex, the central pores of HslU hexamer and HslV dodecamer are aligned and the proteolytic active sites are sequestered in the inner chamber of HslV. Thus, the degradation of natively folded proteins requires unfolding and translocation processes for their access into the proteolytic chamber of HslV. A highly conserved GYVG93 sequence constitutes the central pore of HslU ATPase. To determine the role of the pore motif on protein unfolding and translocation, we generated various mutations in the motif and examined their effects on the ability of HslU in supporting the proteolytic activity of HslV against three different substrates: SulA as a natively folded protein, casein as an unfolded polypeptide, and a small peptide. Flexibility provided by Gly residues and aromatic ring structures of the 91st amino acid were essential for degradation of SulA. The same structural features of the GYVG motif were highly preferred, although not essential, for degradation of casein. In contrast, none of the features were required for peptide hydrolysis. Mutations in the GYVG motif of HslU also showed marked influence on its ATPase activity, affinity to ADP, and interaction with HslV. These results suggest that the GYVG motif of HslU plays important roles in unfolding of natively folded proteins as well as in translocation of unfolded proteins for degradation by HslV. These results also implicate a role of the pore motif in ATP cleavage and in the assembly of HslVU complex.
Construction and Expression of Sugar Kinase Transcriptional Gene Fusions by Using the Sinorhizobium meliloti ORFeome

ABSTRACT The Sinorhizobium meliloti ORFeome project cloned 6,314 open reading frames (ORFs) into a modified Gateway entry vector system from which the ORFs could be transferred to destination vectors in vivo via bacterial conjugation. In this work, a reporter gene destination vector, pMK2030, was constructed and used to generate ORF-specific transcriptional fusions to β-glucuronidase (gusA) and green fluorescent protein (gfp) reporter genes. A total of 6,290 ORFs were successfully transferred from the entry vector library into pMK2030. To demonstrate the utility of this system, reporter plasmids corresponding to 30 annotated sugar kinase genes were integrated into the S. meliloti SM1021 and/or SM8530 genome. Expression of these genes was measured using a high-throughput β-glucuronidase assay to track expression on nine different carbon sources. Six ORFs integrated into SM1021 and SM8530 had different basal levels of expression in the two strains. The annotated activities of three other sugar kinases were also confirmed.
Distribution and occurrence of myxomycetes on agricultural ground litter and forest floor litter in Thailand

The ecological distribution and seasonal patterns of occurrence of myxomycetes associated with the microhabitats represented by agricultural ground litter and forest floor litter were investigated in six study sites in northern Thailand during Oct 2004–Oct 2005. Both specimens that developed under natural conditions in the field and specimens obtained in moist chamber cultures were considered. Agricultural study sites were a banana plantation, a mango orchard and a sweet corn farm, whereas forest study sites consisted of a lowland forest, a midelevation forest and a highland forest. Seventy species of myxomycetes representing 20 genera were collected, with 34 species recorded during the dry season and 58 species recorded during the rainy season. Distinct differences were apparent for numbers of positive moist chambers, numbers of species recorded from moist chambers, numbers of species recorded as field collections and numbers of field collections when data obtained for the two seasons were compared. In the dry season only three species were collected in the field, but the percentage of positive moist chamber cultures (129/180 or 72%) and number of species recorded (33) from these cultures were high. In contrast, during the rainy season, 52 species of myxomycetes were collected in the field but only 15 species were recorded from the much lower percentage (75/180 or 42%) of positive moist chambers cultures.
Oxygen Supersaturation in the Ocean: Biological Versus Physical Contributions

A method based on measurements of dissolved molecular nitrogen, molecular oxygen, and argon can distingish biological from physical contributions to oxygen supersaturation in the ocean. The derived values of biological O2 production can be used as a check on estimates of total organic productivity measured by instantaneous rates of carbon-14 assimilation. Application to the shallow summer O2 maxima in the North Pacific gyres shows that about 72% of the O2 supersaturation maximum at 28�N and about 86% of the maximum at 40�N are due to net photosynthetic production.
A comparison of working memory profiles in children with ADHD and DCD

The main objective of present study was to investigate whether the patterns of working memory performance differ as a function of attention and motor difficulties, and whether children with ADHD and DCD could be reliably discriminated on the basis of their memory deficits. A related aim was to investigate the link between their working memory profiles and academic attainment. Fifty children with ADHD-Combined, 55 children with DCD, and an age-matched group of 50 typically developing children with average working memory were assessed on standardized measures of working memory, IQ, and academic attainment (reading, spelling, comprehension, and math). The normal controls performed significantly better than both clinical groups on all working memory tests. Specific patterns emerged in the memory profile of the clinical groups: The children with DCD had a depressed performance in all working memory tests, with particularly low scores in visuospatial memory tasks; children with ADHD performed within age-expected levels in short-term memory but had a pervasive working memory deficit that impacted both verbal and visuospatial domains. The clinical groups could reliably be discriminated on the basis of their short-term memory scores. Their learning profiles were similar. It is possible that the working memory profiles of the children with ADHD and DCD are influenced by distinct underlying cognitive mechanisms, rather than a general neurodevelopmental delay. Despite these distinctive patterns of memory performance, both clinical groups performed similarly on academic attainments, suggesting that memory may underlie learning difficulties, independent of related clinical disorders.
The Causes of Death in Patients with Human Immunodeficiency Virus Infection: A Clinical and Pathologic Study with Emphasis on the Role of Pulmonary Diseases

The clinical records and autopsy data of 75 patients dying with AIDS were reviewed to determine the frequency of individual diseases diagnosed premortem and postmortem, the significance of pulmonary processes found in the lungs at autopsy, and the clinical and pathologic causes of death. Cytomegalovirus (CMV) infection was identified histologically either premortem or postmortem in 81% of patients. The lungs and adrenal glands were infected most commonly. Only one-half of CMV infections were recognized premortem. Pneumocystis pneumonia and Kaposi sarcoma occurred in 68% and 59% of patients, respectively, but were not unsuspected premortem in any patient. Visceral involvement with Kaposi sarcoma, however, was frequently recognized only at autopsy. While disseminated M. avium-intracellulare infection was common (31% of patients), histologically documented pulmonary disease was uncommon (3% of patients). Cryptococcal infection, diagnosed in 10 patients, was confined to the central nervous system in only 1 patient. Toxoplasma, in contrast, infected the brain of only 6 patients. All 75 patients had one or more disease processes identified in their lungs or pleurae at autopsy. These processes included opportunistic infections in 76% of patients, neoplasms in 37% (Kaposi sarcoma in 36% and lymphoma in 3%), and other processes in 60%. The most prevalent pathogen, CMV was found in pulmonary tissue from 44 patients and caused significant disease in 21 patients. Five patients died due to CMV pneumonia. Pneumocystis carinii was found at autopsy in 24 patients. In spite of treatment, pneumocystis pneumonia was fatal in 11 patients. One patient died with concomitant CMV and pneumocystis pneumonia. Kaposi sarcoma, identified in the lungs of 23 patients, led to death in 5 patients via upper airway obstruction, hemorrhage, or parenchymal destruction. Other fatal pulmonary processes included bacterial pneumonia in 9 patients, idiopathic diffuse alveolar damage in 5, cryptococcosis in 2, and pulmonary hemorrhage in 1. Specific clinical criteria were used to determine the cause of death due to organ system failure. Fifty-one percent of patients died due to respiratory failure; 16% from neurologic disease; 17% from hypotension that was not caused by respiratory, neurologic, or cardiac disease; and 3% from cardiac dysfunction. Thirteen percent of deaths did not meet the clinical criteria defining these 4 categories. This clinical assessment was combined with autopsy data to identify specific diseases as causes of death. (ABSTRACT TRUNCATED AT 400 WORDS)
A Low-Cost Pipelined BIST Scheme for Homogeneous RAMs in Multicore Chips

Multicore system-on-chip (SOC) design is widely used for current high-performance applications. Multicore SOCs typically include a large amount of homogeneous memory cores (i.e., memory cores have the same size and configuration). This paper proposes a pipelined built-in self-test (PBIST) scheme for homogeneous memory cores in multicore SOCs. A PBIST circuit can be shared by clustered multiple homogeneous memories. This drastically reduces the hardware overhead of the PBIST circuit. A systematic procedure for converting a march test into a pipelined march test is also proposed. Experimental results show that the area overhead of a pipelined BIST for eight homogeneous 1k times 128-bit memories is only about 0.71%.
Bit-error probability for an adaptive diversity receiver in a Rayleigh-fading channel

The bit-error probability is determined for a binary antipodal diversity system with an adaptive receiver using decision-directed channel estimation. The diversity channels are assumed to be nonselective Rayleigh-fading channels with additive white Gaussian noise (AWGN). The analysis is valid for all linear estimators which use a finite-impulse-response (FIR)-type estimation filter. Numerical results are presented for a minimum mean-square error (MMSE) filter and a moving average (MA) filter.
Pre- and Postoperative Photographs and Surgical Outcomes in Patients With Lenke Type 1 Adolescent Idiopathic Scoliosis

Study Design. Clinical study with pre- and postoperative back photographs and postoperative Scoliosis Research Society-22 survey in patients who had undergone surgery for idiopathic scoliosis. Objective. To determine the effect of showing patients their photographs before and after surgery for idiopathic scoliosis on postoperative patient satisfaction. Summary of Background Data. After scoliosis surgery, patient satisfaction may be limited because the patients cannot directly see their back and may forget the preoperative appearance. Methods. In 60 patients who had undergone surgery for correction of idiopathic scoliosis (Lenke type 1), pre- and postoperative photographs were taken from the anterior, posterior, and right and left lateral views. After surgery, patients in group 1 (30 patients) were shown the preoperative and most recent follow-up photographs, and patients in group 2 (30 patients) had routine evaluation but were not shown their photographs. All patients completed the Scoliosis Research Society-22 survey. Results. Patients in both groups had similar age, sex, distribution of Lenke type and Risser sign, follow-up, and pre- and postoperative Cobb angles and balance (coronal and sagittal). A significant difference was observed between the groups for survey question 10 (which was about self-image), question 18 (which was about function and activity), and question 21 (which was about satisfaction) (P ⩽ 0.05). There were no differences between patients in groups 1 and 2 in Scoliosis Research Society-22 domain or total scores. Conclusion. By showing patients the pre- and postoperative clinical photographs, patient satisfaction may be greater, as measured with some SRS-22 scores. This method may enable clinicians to positively change the patients' self-image perception after surgery for correction of scoliosis. Level of Evidence: 4
Crystal structure of an endotoxin‐neutralizing protein from the horseshoe crab, Limulus anti‐LPS factor, at 1.5 A resolution.

Lipopolysaccharide (LPS), or endotoxin, is the major mediator of septic shock, a serious complication of Gram‐negative bacterial infections in humans. Molecules that bind LPS and neutralize its biological effects or enhance its clearance could have important clinical applications. Limulus anti‐LPS factor (LALF) binds LPS tightly, and, in animal models, reduces mortality when administered before or after LPS challenge or bacterial infection. Here we present the high resolution structure of a recombinant LALF. It has a single domain consisting of three alpha‐helices packed against a four‐stranded beta‐sheet. The wedge‐shaped molecule has a striking charge distribution and amphipathicity that suggest how it can insert into membranes. The binding site for LPS probably involves an extended amphipathic loop, and we propose that two mammalian LPS‐binding proteins will have a similar loop. The amphipathic loop structure may be used in the design of molecules with therapeutic properties against septic shock.
Aspartate‐containing neurons of the brainstem and rostral spinal cord of the sea lamprey Petromyzon marinus: Distribution and comparison with γ‐aminobutyric acid

The amino acid L‐aspartate (ASP) is one of the most abundant excitatory neurotransmitters in the mammalian brain, but its distribution in other vertebrates has not yet been well characterized. We investigated the distribution of ASP in the brainstem and rostral spinal cord of the adult sea lamprey by using ASP immunohistochemistry. Our results indicate that ASP is accumulated in specific neurons, but not in glia (tanycytes). ASP‐immunoreactive neuronal populations were rather similar as the glutamatergic populations reported in the adult sea lamprey (Villar‐Cerviño et al. [2013] J Comp Neurol 521:522–557), although some important differences were noted. Characteristically, the largest reticular neurons of the lamprey brainstem (Müller cells) showed ASP immunoreactivity in perikarya and processes, in contrast to the absence or faint glutamate immunoreactivity reported in these perikarya. We also compared the distribution of ASP and γ‐aminobutyric acid (GABA) in brainstem neurons by using double immunofluorescence methods. In regions such as the midbrain tectum, dorsal isthmus, and motor nuclei, ASP and GABA immunoreactivity was mostly located in different neurons, whereas in other nuclei (torus semicircularis, octavolateralis area, parvocellular reticular formation), many of the ASP‐immunonegative neurons displayed colocalization with GABA. These results, together with those of our previous studies of colocalization of glutamate and GABA, suggest that some lamprey neurons may co‐release both excitatory and inhibitory neurotransmitters. Further investigation is needed to elucidate the pathways of uptake and release of ASP by ASP‐immunoreactive neurons. Our results indicate that ASP is a neurotransmitter in the central nervous system representative of agnathans, the earliest vertebrate group. J. Comp. Neurol. 522:1209–1231, 2014. © 2013 Wiley Periodicals, Inc.
Optimal parameters for laser tissue soldering. Part I: Tensile strength and scanning electron microscopy analysis

The use of liquid and solid albumin protein solders to enhance laser tissue repairs has been shown to significantly improve postoperative results. The published results of laser‐solder tissue repair studies have, however, indicated inconsistent success rates. This can be attributed to variations in laser irradiance, exposure time, solder composition, chromophore type, and concentration. An in vitro study was performed using indocyanine green‐doped albumin protein solders in conjunction with an 808 nm diode laser to determine optimal laser and solder parameters for tissue repair in terms of tensile strength and stability during hydration.