Miracle-dz/UniFAR-FTUs huggingface dataset:
Presentation, Management, and Outcome of Thyroglossal Duct Cysts in Adult and Pediatric Populations: A 14-Year Single Center Experience.

OBJECTIVES A thyroglossal duct cyst (TDC) is a frequent congenital midline anomaly of the neck that usually manifests during the first decade of life. We aimed to describe the presentation, management, and outcome of TDC in pediatric and adult cases. METHODS A retrospective observational analysis was conducted for all patients diagnosed and treated for TDC between 2000 and 2014 in a single center in Qatar. Data included patients' demographics, presentations, preoperative investigations, anesthesia type, histopathological findings, surgical management, recurrences, and complications. RESULTS We identified 102 patients, of which 57% were males. The mean age of patients was 20.2±15.6 years. A bimodal distribution of TDC has been observed, which peaked between the ages of 6-13 years and at ≥19 years. The preoperative evaluation mainly includes ultrasonography (66%), thyroid function test (44%), and fine-needle aspiration cytology (10%). The median size of the cyst was 25 (2-60) mm. Patients mainly presented with an asymptomatic midline neck mass at or below the hyoid bone (82%), followed by fistula (9%), infection (2%), and dysphagia (2%). Eighty-nine cases were identified preoperatively as TDC. The histopathological findings confirmed TDC with hyoid bone in 61 cases, and TDC alone in 38 cases. Eighty patients underwent the Sistrunk procedure while excision of TDC alone was observed in 18 cases. Five cases of recurrent disease were also treated. Adults had a greater median cyst size (30 (9-60) vs. 22 (2-55) mm; p = 0.005) and required prolonged operation time (69 (1-169) vs. 32.5 (1-140) mins; p = 0.004) compared to the pediatric group. CONCLUSION The occurrence of TDC shows a bimodal age distribution. Preoperative evaluation and time for surgery vary whereas clinical presentations, surgical management, and postoperative outcomes are comparable among adult and pediatric groups. Ultrasonography is the preferred diagnostic modality, and the Sistrunk procedure remains the primary choice of treatment.
Treatment of primary central nervous system lymphoma with induction of complement‐dependent cytotoxicity by intraventricular administration of autologous‐serum‐supplemented rituximab

We describe an immunocompetent 19‐year‐old man with CD20‐positive primary central nervous system (CNS) lymphoma refractory to chemotherapy and irradiation. After intraventricular administration of rituximab, a chimeric anti‐CD20 monoclonal antibody, supplemented with autologous serum, a remarkable response developed to the CNS parenchymal lymphoma. Cytotoxicity assays showed that untreated patient's serum with rituximab, but not that of heat‐inactivated patient's serum with rituximab or rituximab alone, induced potent rituximab‐mediated cytotoxicity against tumor cells in the patient's cerebrospinal fluid, suggesting induction of complement‐dependent cytotoxicity against CNS lymphoma. (Cancer Sci 2006; 97: 80 –83)
Exploring Factors that Influence Domestic Tourists’ Satisfaction with Budget Hotel Services in Egypt

This paper aims to explore the primary factors that affect the perception of domestic tourists towards the service quality of budget hotels in Egypt. The factors were divided into three main constructs: physical quality, service quality and value for money. The primary findings reveal that the budget hotel location, cleanliness, maintenance, comfort level, hotel staff service, value for money room rates and food and beverage values are among the significant factors that influence domestic tourist satisfaction within predefined constructs. Primary Elements associated with the budget hotel stay were also ranked according to guest satisfaction.
The plasmid prophage N15: a linear DNA with covalently closed ends

Coliphage N15 is a temperate bacteriophage whose prophage is a linear plasmid molecule with covalently closed ends (telomeres). The N15 prophage provided the first example of such DNA in prokaryotes and, up to now, it is the only known example of a linear plasmid in Escherichia coli. The linear N15 mature phage DNA has single‐stranded cohesive ends. The phage and plasmid prophage DNAs are circularly permuted. The nucleotide structure of the telomere‐forming site tel RL in phage DNA corresponds to the structures of the terminal hairpin loops. It suggests a unique mechanism for conversion of the circular phage DNA to the linear plasmid form, which is performed by the prokaryotic telomerase (protelomerase). The results of a comparison of the protelomerase with integrases lead us to suggest that these proteins may have evolved from a common ancestor. The mechanism of plasmid N15 replication is unknown. We propose that the protelomerase participates in linear plasmid replication, acting as a resolvase of replicative intermediates that are tail‐to‐tail linear dimers. The sequence analysis of the N15 DNA showed that it represents an evolutionary ‘link’ between plasmids F, P1, P4 and lambdoid bacteriophages.
The Effect of Right-to-left Shunt on the Rate of Increase of Arterial Anesthetic Concentration

Right-to-left shunt was produced in dogs by placing a bronchial blocker in the left main-stem bronchus. Compared with the arterial concentrations attained with both lungs ventilated, right-to-shunt significantly slowed the rate of increase of arterial cyclopropane. Arterial cyclopropane concentrations at 1, 3, 5, 10, and 20 minutes were 30, 27, 26, 22, and 14 per cent less than the concentrations present at the same times with both lungs ventilated. The rate of increase of arterial methoxyflurane was not altered, while halothane's rate of increase occupied an intermediate position. Increases in arterial halothane concentrations were slower in three patients with tetralogy of Fallot prior to closure of the ventricular septal defects. At 1, 3, 5, 10, and 20 minutes, arterial halothane concentrations were 23, 17, 13, 11, and 8 per cent less than the corresponding concentrations after elimination of the right-to-left shunts.
Effect of Compensation and Benefit to Employee Engagement through Organisation Brand in Indonesia’s Startup Company

Startup business in Indonesia has become a popular way to start the business. Startup is as well a promised business in thefiled og investation and pay/salary. Does pay and facility is suit well with their job description and makes the engage to company? This paper tests the hypothesis that compensation and benefit have effect on employee engagement with organisation brand in between. Result shows that organisation brand failed to be mediating variable just because only compensation who have effect, that is on organisation brand and employee engagement. Which engagement is affected as well by compensation.
Caring for mental illness in the United States: a focus on older adults.

OBJECTIVE The authors compared rates of common mental disorders and the use of primary care and specialty mental health services among younger and older adults. METHODS They used data from 9,585 respondents to the HealthCare for Communities (HCC) Household Telephone Survey. Mental disorders during the past year, including depression, dysthymia, and generalized anxiety disorder, were identified with a short questionnaire. The survey also collected information about sociodemographic and insurance status, perceived need for mental health care, and use of health services. RESULTS Older adults (age 65 and older) were significantly less likely than younger adults (18-29) or middle-aged adults (30-64) to meet diagnostic criteria for a mental disorder (8% versus 15% in each of the younger age-groups). Older adults who met diagnostic criteria for mental disorders were less likely to perceive a need for mental health care, to receive specialty mental health care or counseling, or to receive referrals from primary care to mental health specialty care than young or middle-aged adults. CONCLUSION Few older adults with mental disorders use mental health services, particularly specialty mental health services. The lack of perceived need for mental health care may contribute to low rates of mental health service use among older adults.
ANALISIS PENGARUH JOB INSECURITY TERHADAP KEPUASAN KERJA DAN KOMITMEN ORGANISASIONAL SERTA DAMPAKNYA TERHADAP KINERJA KARYAWAN OUTSOURCING PT UPAYA KELOLA PROFITAMA

This study is purposed to analyze the influence of job insecurity towards job satisfaction and organizational commitment and its result on job performance from outsourcing employees that works in PT Upaya Kelola Profitama Malang. This study uses job insecurity, job satisfaction and organizational commitment as variables to analyze outsourcing employee's job performance. Besides, this study is purposed to analyze the influence of job insecurity towards job performance which is moderated by job satisfaction and also organizational commitment. The influence of job insecurity towards organizational commitments which is moderated by job satisfaction is also analyzed. The population of this study are the outsourcing employees of PT Upaya Kelola Profitama Malang, the populations are 248 with 154 samples are being used on three divisions : cleaning service, parking and security. The data gathered using questionnaires method by giving the list of the questions or questionnaires directly to the respondent. The method that is used in this study is Ordinary Least Square (OLS) with SPSS software version 15.0. The result of this study shows that variables job insecurity, job satisfaction and organizational commitment have direct effect towards employee's job performance. This study also shows that there is an indirect and significant influence of job insecurity towards job performance through job satisfaction and organizational commitment. Keywords : Job Insecurity, Job Satisfaction, Organizational Commitment, Job Performance, Outsourcing Employees.
Randomized study of the safety and clinical utility of rotational angiography versus standard angiography in the diagnosis of coronary artery disease

This study evaluates the safety and clinical utility of rotational angiography in the diagnosis of coronary artery disease. High‐speed rotational angiography is a newly available angiographic modality that gives a dynamic multiple‐angle perspective of the coronary tree during a single contrast injection. We prospectively randomized 56 patients referred for diagnostic coronary angiography to either standard or rotational angiography. Contrast and radiation utilization were compared between the two groups. The number of additional cine acquisitions needed was used to determine adequacy of the diagnostic study protocol. Rotational angiography was successfully completed in all subjects. There was a 33% reduction in contrast utilization in the rotational group as compared to the standard group (35.6 ± 12.6 vs. 52.8 ± 10.7 ml, respectively; P < 0.0001). Additionally, there was a 28% reduction in total radiation exposure in the rotational group as compared to the standard group (39.0 ± 18.5 vs. 53.9 ± 23.4 Gycm2, respectively; P = 0.01). Total whole‐body radiation exposure to the primary operator was 144 mrem with rotational angiography and 170 mrem with standard angiography. Procedure time tended to be shorter for rotational angiography (353.9 ± 146.7 vs. 396.8 ± 165.8 s; P = 0.3). Rotational coronary angiography can be rapidly performed in any patient and provides a significant reduction in contrast and radiation utilization while at the same time providing adequate angiographic data to complement or replace standard coronary angiography in the evaluation of coronary artery disease. Catheter Cardiovasc Interv 2004;62:167–174. © 2004 Wiley‐Liss, Inc.
Increased mortality in long-term intensive care patients with active cytomegalovirus infection*

Objective:To determine the prevalence and impact on patient outcome of active human cytomegalovirus infections in patients with prolonged treatment in an intensive care unit. Design:Retrospective analysis of stored plasma samples. Setting:Anesthesiological intensive care unit of a university hospital. Patients:All 138 patients treated for at least 14 days (of a total of 4940 patients admitted during the study period). Immunocompromised patients and patients with inconclusive results for cytomegalovirus DNA were excluded. Interventions:None. Measurements and Main Results:Stored plasma samples of patients with prolonged intensive care unit stay were tested for cytomegalovirus DNA. Sixty-four of 255 evaluable samples from 99 immunocompetent patients tested cytomegalovirus DNA-positive with a mean DNA concentration of 8,600 genome equivalents per milliliter. Active cytomegalovirus infection was diagnosed by reproducibly positive results in 35 patients (35%). Only one case had been diagnosed clinically. Patients with and without active cytomegalovirus infection were not significantly different in parameters, such as age, sex, admission category, source of admission, or comorbidities. Even review of specific surgical procedures or the use of a heart-lung–machine showed no significant differences between the groups. The mortality rate in patients with cytomegalovirus infection was significantly increased (28.6% vs. 10.9%, p = 0.048), and surviving patients had a longer intensive care unit stay (32.6 vs. 22.1 days, p <0.001). Conclusions:Active cytomegalovirus infection is a frequent but seldom diagnosed finding in surgical patients with prolonged intensive care unit stay, which is associated with increased mortality and prolonged intensive care unit stay of surviving patients.
Improving The Compliance With Accounting Standards Without Public Accountability (SAK ETAP) By Developing Organizational Culture: A Case Of Indonesian SMEs

In Indonesia’s economy SMEs have significant contribution to GDP and labor employment. On the other hand, SMEs still have substantial problems. One of them is related to capital insufficiency due to limited access of SMEs to financial institutions. This limitation may be caused, among other things, by the fact that SMEs’ financial statements have not complied with Accounting Standards without Public Accountability (SAK ETAP). The study aims at identifying antecedents of SAK ETAP implementation as well as formulating strategies to improve its implementation in SMEs. Five important antecedents of SAK ETAP implementation are organizational culture, education, exposure, age, and scale. Therefore, developing organizational culture by increasing SMEs’ exposure on socialization and training is a promising strategy. There is also a need for more intensive cooperation of various parties such as government, Institute of Indonesian Chartered Accountants (IAI), universities, SME association, and NGOs to improve both SMEs’ compliance with SAK ETAP and organizational culture. In addition, mobilization of academic staffs and accounting students to facilitate the implementation of SAK ETAP is worth-trying.
Essential Role of the MyD88 Pathway, but Nonessential Roles of TLRs 2, 4, and 9, in the Adjuvant Effect Promoting Th1-Mediated Autoimmunity

Induction of tissue-specific experimental autoimmune diseases involves an obligatory adjuvant effect to trigger an innate response of a type that will drive a Th1-biased adaptive response. This is achieved by use of CFA containing mycobacteria (Mycobacterium tuberculosis), whose recognition by cells of the innate immune system depends on TLRs that signal through the adaptor molecule MyD88. We examined the role of selected components of the MyD88 pathway in promoting experimental autoimmune uveitis (EAU). Mice deficient in MyD88, TLR2, TLR4, or TLR9 were immunized with the retinal Ag interphotoreceptor retinoid-binding protein in CFA, and their EAU scores and associated immunological responses were examined. MyD88−/− mice were completely resistant to EAU and had a profound defect in Th1, but not Th2, responses to autoantigen challenge. Surprisingly, TLR2−/−, TLR4−/−, and TLR9−/− mice were fully susceptible to EAU and had unaltered adaptive responses to interphotoreceptor retinoid-binding protein. Examination of IL-1R family members, which share the common adaptor MyD88 with the TLR family, revealed that IL-1R-deficient mice, but not IL-18-deficient mice, are resistant to EAU and have profoundly reduced Th1 and Th2 responses. These data are compatible with the interpretation that TLR9, TLR4, and TLR2 signaling is either not needed, or, more likely, redundant in the adjuvant effect needed to induce EAU. In contrast, signaling through the IL-1R plays a necessary and nonredundant role in EAU and can by itself account for the lack of EAU development in MyD88 mice.
Corporate Governance, Financial Ratios, Political Risk and Financial Distress: A Survival Analysis

". Objective – The objective of this study was to investigate the factors like corporate governance, financial ratios, and political risk and their impacts on company’s survival. Methodology/Technique – Collecting data of Indonesian Stock Exchange from 2000 to 2014 and employing purposive random sampling, this research collects samples of 58 companies undergoing financial distress and 275 others which do not. Findings – The research eventually proves that agency theory and Asymmetric Information theory do occur in Indonesia. With Cox Proportional Hazard model, it then proves that all two models employed: independence commissioners, leverage, operating risk, size, return on asset and control of corruption, are variables which consistently affect financial distress of the company. Novelty – The study uses original data and gives supported suggestion for the researched issues. "
Use of alpha-interferon in the treatment of chronic delta hepatitis.

Chronic delta hepatitis is a severe disease with a rapidly progressive course for which currently no effective treatment exists. Treatment with alpha-interferon (alpha-IFN) can inhibit HDV replication and improve serum chemistries in a number of patients. Meta-analysis of five randomized controlled trials using at least 5 MU/m2 of alpha-IFN t.i. w. for a minimum of 3 months showed that alpha-IFN had a statistically significant effect in normalizing ALT values during therapy at a p level of less than 0.001, with a 10.24 odds ratio and a 28.69% risk difference (Mantel-Haentzel-Peto chi 2 = 24.13) but had no significant effect on ALT activity after its discontinuation. From hitherto available results, it appears that the best treatment schedule is a 5 MU standard dose of alpha-IFN given daily (QD) or 9 MU t.i. w. for at least 1 year, which is associated with a remission of the disease in 50-70% of patients. A trial conducted in Greece showed that the mean duration of disease remission under alpha-IFN therapy was 3.8 months per year compared to 1.7 months per year of non-treatment (relative risk = 2.8). Unlike hepatitis B, no factors predictive of the response to alpha-IFN therapy have been identified except, perhaps, for the duration of the disease. No adjuvants have been found to enhance the efficacy of alpha-IFN treatment and no therapeutic alternatives are available at present. Advances in understanding HDV replication and the pathogenetic mechanisms in chronic delta hepatitis may bring about significant improvement in its therapy in the future.
A study of asset comovement, integration and contagion in country, style and industry portfolios

13 Declaration . 14 Copyright Statement . 15 Acknowledgement . 16 CHAPTER ONE . 17 1.1. Motivation of the thesis . 17 1.2. Introduction to contagion: definitions and methodology . 23 1.3. Thesis structure . 28 References . 29 CHAPTER TWO . 33 2.1. Introduction . 33 2.2. Literature review . 33 2.2.1. Overview of shock transmission channels . 38 2.2.2. Patterns of integration . 40 2.2.3. Contagion . 42 2.2.4. Testable hypotheses . 44 2.3. Methodology . 46 2.3. 1. A structural regime-switching factor model . 47 2.3. 2. Contagion tests . 47 2.4. Data . 53 2.4. 1. Stock return data . 53 2.4. 2. Descriptive statistics of country portfolios . 53 2.4. 3. Conditioning Information and Structural Instruments . 55 2.5. Empirical results . 55 2.5. 1. Country time-varying beta . 59
NDRG 2 positively regulates E-cadherin expression and prolongs overall survival in colon cancer patients

To discover the molecular mechanism of N-Myc downstream-regulated gene 2 (NDRG2), a newly found differentiation-related tumor suppressor, the relationships between NDRG2 and E-cadherin were investigated in tumor cells and tissues. Positive correlations between the expression of E-cadherin and NDRG2 were shown in several colon cancer cell lines as well as in colon cancer tissues. According to the transcription assays using a reporter plasmid containing E-cadherin promoter region (-368~+51), NDRG2 introduction into colon cancer cell lines induced upregulation of E-cadherin promoter activity and its transcription. On the contrary, inhibition of NDRG2 expression by siRNA treatment caused the decrease of E-cadherin transcription. Snail, a zincfinger transcriptional repressor, was shown to be a mediator of NDRG2-regulated E-cadherin expression. The enhancement of glycogen synthase kinase 3β (GSK-3β) activity by NDRG2 overexpression caused proteasomal degradation of Snail transcription factor followed by transcriptional de-repression of E-cadherin. We also found that NDRG2 could mediate cell density-regulated E-cadherin expression. The increase of NDRG2 expression with cell density preceded E-cadherin expression, and the regulation of Snail activity by GSK-3β was also related to this process.
The Development and Validation of a Measure of Student Attitudes Toward Science, Technology, Engineering, and Math (S-STEM)

Using an iterative design along with multiple methodological approaches and a large representative sample, this study presents reliability, validity, and fairness evidence for two surveys measuring student attitudes toward science, technology, engineering, and math (S-STEM) and interest in STEM careers for (a) 4th- through 5th-grade students (Upper Elementary S-STEM) and (b) 6th- through 12th-grade students (Middle/High S-STEM). Findings from exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) suggested the use of a four-factor structure to measure student attitudes toward science, math, engineering/technology, and 21st century skills. Subject matter experts and literature reviews provided evidence of content validity. Reliability levels were high for both versions. Furthermore, both the Upper Elementary S-STEM and Middle/High S-STEM Surveys demonstrated evidence of configural, metric, and scalar invariance across grade levels, races/ethnicities, and genders. The findings support the validity of interpretations and inferences made from scores on the instruments’ items and subscales.