Miracle-dz/UniFAR-FTUs huggingface dataset:
Sound level measurements from audio recordings provide objective distance estimates for distance sampling wildlife populations

Distance sampling is widely used to estimate animal population densities by accounting for imperfect detection of individuals with increasing distance from an observer. Distance sampling assumes that distances are measured without error; however, it is often applied to human estimated distances, which are known to be inconsistent, inaccurate, and biased. We present an objective technique for estimating distance to vocalizing individuals that relies on the relative sound level (RSL) of the vocalization extracted from autonomous recording unit (ARU) recordings and show the error is less than human estimated error extracted from a literature case study. RSL predicted distances can be obtained by manual measurement in sound viewing software, or automatically with automated signal recognition software. We built calibration datasets of Ovenbirds (Seiurus aurocapilla) and Common Nighthawks (Chordeiles minor) recorded at known distances and used regression of RSL from those recordings to predict distance. There was no error bias of RSL predicted distances when compared to known distances for Common Nighthawk, minimal error bias for Ovenbird, and error from all RSL predicted distances was less than human estimated error extracted from the literature. We then simulated ARU point count surveys with a known density and estimated that density with distance sampling to test whether RSL distance prediction does not violate the assumption that distances are measured without error. There was no difference in density estimates from known distance and density estimates obtained from RSL predicted distance, while density estimates contaminated with human estimated error were significantly lower than density estimates from known distance. We found that a calibration dataset of approximately 300 vocalizations was suitable to minimize error for both species, and so conclude that RSL distance prediction is an accessible method of improving distance estimates relative to human estimation. We provide general recommendations on how to collect calibration recordings for the application of RSL distance prediction to other species and areas.
Factors associated with a learning effect in glaucoma patients using automated perimetry

Abstract. We studied 45 primary open‐angle glaucoma patients consecutively examined with the program 30–2 on the Humphrey Field Analyzer to determine factors associated with a learning effect between the first two visual field exams. The average mean defect significantly decreased 1.7 dB between exams (P<0.05). No difference was noted in learning based on: the time interval between tests, the area of the field tested, age, sex, race, previous perimetric experience or parameters on the initial field exam (i.e. prevalence of false positive and negative errors, central reference level and eye tested (P<0.05). However, learning positively correlated to defect depth and negatively correlated to fixation losses on the initial exam in patients retested within seven months (P<0.05). This study suggests predicting which patients require a second baseline field exam to exclude a learning effect is difficult, except in those with glaucomatous field loss or few fixation losses and another field is planned within a half year.
Drugs, alcohol and violence in 604 male offenders referred for inpatient psychiatric assessment.

Of 604 White and Coloured male offenders in the Cape referred for inpatient psychiatric observation, 52% habitually indulged heavily in alcohol, drugs (mostly dagga (cannabis)) or both. Indulpence in alcohol alone was frequently associated with violence and sexual assaults, alcohol and drugs together less, and drugs alone least. Those who indulged in drug-taking (i.e. dagga, LSD and hard drugs) were less frequently associated with violence, rape and other sex crimes than were those who did not; 60% of sex offenders were non-abusers. Out of 101 severely psychopathic patients in the sample, only 1 who indulged in drugs but not alcohol was charged with a crime of violence or sex. There was no evidence of a potentiating action between alcohol and dagga towards violent behaviour. Dagga appeared to diminish the action of alcohol, and may inhibit urges toward violence and rape in aggressive persons and psychopaths. Drugs did not release or set off violent reactions, and drug indulgence was associated with stealing without violence. Some implications for forensic psychiatry and arguments about drug indulgence as an extenuating factor in serius crime are discussed.
Induction of autoimmune response to the extracellular loop of the HERG channel pore induces QTc prolongation in guinea‐pigs

Channelopathies of autoimmune origin are novel and are associated with corrected QT (QTc) prolongation and complex ventricular arrhythmias. We have recently demonstrated that anti‐SSA/Ro antibodies from patients with autoimmune diseases and with QTc prolongation on the ECG target the human ether‐à‐go‐go‐related gene (HERG) K+ channel by inhibiting the corresponding current, IKr, at the pore region. Immunization of guinea‐pigs with a peptide (E‐pore peptide) corresponding to the extracellular loop region connecting the S5 and S6 segments of the HERG channel induces high titres of antibodies that inhibit IKr, lengthen the action potential and cause QTc prolongation on the surface ECG. In addition, anti‐SSA/Ro‐positive sera from patients with connective tissue diseases showed high reactivity to the E‐pore peptide. The translational impact is the development of a peptide‐based approach for the diagnosis and treatment of autoimmune‐associated long QT syndrome.
Influence of grain and monensin supplementation on ruminal fermentation, intake, digesta kinetics and incidence and severity of frothy bloat in steers grazing winter wheat pastures.

Three 10-d collection periods (April 4 to 14, early April, EApr; April 23 to May 3, late April, LApr; May 10 to 20, 1984, mid-May, MMay) were conducted to evaluate effects of no supplement (C), . 5 kg-head-1.d-1 (as-fed basis) supplemental grain (steam-flaked milo, G) or G plus 170 mg monensin.head-1.d-1 (M) on forage intake and digestion by 12 ruminally cannulated beef steers (four/treatment; avg initially BW = 393 kg) grazing irrigated winter wheat pasture. Ruminal pH was greater (P less than .01) for M than for C or G during EApr but was not altered by treatments in LApr or MMay. Compared with C, ruminal NH3 was decreased (P less than .10) by G and M (5 h after supplementation) in EApr, decreased (P less than .05) by G (2h) and increased (P less than .05) by M (8 h) in LApr and decreased (P less than .10) by G (-1h) in MMay. Treatments had little influence on total VFA concentrations or on molar proportions of acetate and propionate. Butyrate molar proportion was decreased (P less than .10) by M during EApr and LApr, but not during MMay. Monensin increased (P less than .05) fluid passage rate compared with C and G in EApr but not in other periods, Particulate passage measurements did not differ (P greater than .10) among treatments within periods. Forage DM intake was not influenced (P greater than .10) by supplementation during any period. Extent of in situ forage DM disappearance was greater (P less than .10) for M than for C or G during EApr (12 and 30 h of incubation) but was not different (P greater than .10) in LApr or MMay. Incidence of frothy bloat was decreased (P less than .05) by M during EApr; this reduction may have been related to effects of M on ruminal pH, forage digestion and fluid passage.
Computer Efficacy, Use and Phobia: Contributions to Nigerian Undergraduates' Academic Performance in a Computer Graphics Course

This study investigated the extent to which computer efficacy, computer use, and computer phobia predicted the level of students’ academic performance in a Computer Graphics course. One hundred eighty-nine undergraduates of the Faculty of Education, Olabisi Onabanjo University, Nigeria, served as the sample for this study. The study sample responded to four instruments: Computer Self-Efficacy Scale (CSES), Computer Use Scale (CUS), Computer Phobia Scale (CPS) and Computer Performance Test (CPT). Pearson Product Moment Correlation, Multiple Regression and Analysis of Variance statistical tools were used to investigate the predictive capacity of the independent on the dependent variables. The findings revealed the three independent variables, when taken together, were effective in predicting students’ academic performance in a Computer Graphics course. Meanwhile, each of the variables also contributed to the prediction of students’ academic performance in a Computer Graphics course with computer use making the highest and a significant contribution to the prediction of the outcome measure (students’ academic performance in a Computer Graphics course). On the basis of these findings, it was suggested higher education institutions in developing countries should make a major paradigm shift from the traditional instructional environment to promoting paperless classrooms and facilitate students’ intense use of computer technologies by making assignments and projects writing, seminar presentations, display of course outlines and reference materials, and academic enquiries more computer-oriented.
Cross-Reactions between the Cytotoxic T-Lymphocyte Responses of Human Immunodeficiency Virus-Infected African and European Patients

ABSTRACT The great variability of protein sequences from human immunodeficiency virus (HIV) type 1 (HIV-1) isolates represents a major obstacle to the development of an effective vaccine against this virus. The surface protein (Env), which is the predominant target of neutralizing antibodies, is particularly variable. Here we examine the impact of variability among different HIV-1 subtypes (clades) on cytotoxic T-lymphocyte (CTL) activities, the other major component of the antiviral immune response. CTLs are produced not only against Env but also against other structural proteins, as well as some regulatory proteins. The genetic subtypes of HIV-1 were determined for Env and Gag from several patients infected either in France or in Africa. The cross-reactivities of the CTLs were tested with target cells expressing selected proteins from HIV-1 isolates of clade A or B or from HIV type 2 isolates. All African patients were infected with viruses belonging to clade A for Env and for Gag, except for one patient who was infected with a clade A Env-clade G Gag recombinant virus. All patients infected in France were infected with clade B viruses. The CTL responses obtained from all the African and all the French individuals tested showed frequent cross-reactions with proteins of the heterologous clade. Epitopes conserved between the viruses of clades A and B appeared especially frequent in Gag p24, Gag p18, integrase, and the central region of Nef. Cross-reactivity also existed among Gag epitopes of clades A, B, and G, as shown by the results for the patient infected with the clade A Env-clade G Gag recombinant virus. These results show that CTLs raised against viral antigens from different clades are able to cross-react, emphasizing the possibility of obtaining cross-immunizations for this part of the immune response in vaccinated individuals.
The roles of consolidation and maintenance therapy with novel agents after autologous stem cell transplantation in patients with multiple myeloma

Novel agents including immunomodulatory drugs and proteasome inhibitors incorporated into induction regimens and subsequently followed by autologous stem cell transplantation in cases of multiple myeloma have resulted in enhancement of response rate and its depth. Maintaining or even improving the response is an important treatment goal. Most clinical trials have revealed increased progression‐free survival after consolidation and maintenance therapy. Some of them have also shown prolongation of overall survival. However, continuous therapy may be associated with significant side effects and costs, and therefore remains controversial. Treatment decisions should be individualized and based upon projected benefits and risks.
Secukinumab - First in Class Interleukin-17A Inhibitor for the Treatment of Psoriasis

Psoriasis is a complex inflammatory disease that occurs in genetically susceptible individuals and presents with the development of erythematous scaly plaques on the skin. Interleukins (ILs) in the Th17 pathway play a pivotal role in the pathogenesis of psoriasis and have thus become targets for recent biologic drug development. Secukinumab is a human monoclonal IgG1k antibody that has been developed to target and block the actions of IL-17A. Secukinumab recently approved for use as first-line systemic therapy in a patient with moderate to severe psoriasis has been studied first in psoriasis before other diseases. Both Phase II and III clinical trials have demonstrated the effectiveness of secukinumab in the treatment of moderate-to-severe plaque psoriasis, and it has demonstrated superiority to other comparable biologics on the market, including the tumor necrosis factor inhibitor etanercept. Secukinumab has also shown superiority to ustekinumab, a relatively recent biologic introduced for the treatment of psoriasis. Besides demonstrating better efficacy compared to etanercept and ustekinumab, secukinumab has also demonstrated a greater impact of the quality of life of patients with a comparable safety profile. Secukinumab shows great promise in having a tremendous impact on the treatment of plaque psoriasis based on its ability to produce similar, if not better, clinical outcomes than other biologic antipsoriasis medications.
The globalization of the business sector in a small open economy: the case of Denmark and its wider implications

The growth of multinational corporations (MNCs) is often taken as a quintessential indicator of ‘globalization’. But recent detailed empirical analysis has challenged the idea that most MNCs are global in terms of their business strategy and arena of operations. This article first clarifies the differences between globalization, internationalization and supranational-regionalization by examining the evidence on trade and investment patterns for Denmark. In particular, it presents a detailed analysis of the business strategies of the large corporate sector in Denmark. Denmark is an interesting case, as it is a small open economy (SOE) that might be thought to be one uniquely vulnerable to the forces of globalization. Up until now examination of MNCs’ internationalization strategies has concentrated upon large economies. We provide evidence for a SOE. In addition, we expand the range of dimensions used to consider internationalization beyond the location of turnover (sales) to include measures of company assets, employment and physical investment. Furthermore, in the light of the analysis of this company sector, we explore the public policy implications of our results for the future of SOEs in a rapidly changing international business environment.
Limited functions of Hox genes in the larval development of the ascidian Ciona intestinalis

In animals, region specific morphological characters along the anteroposterior axis are controlled by a number of developmental genes, including Hox genes encoding homeodomain transcription factors. Although Hox genes have been regarded to play a key role in the evolution of morphological diversity, as well as in the establishment of the body plan, little is known about the function of Hox genes in invertebrates, except for in insects and nematodes. The present study addresses the role of Hox genes in body patterning during the larval development of the ascidian Ciona intestinalis conducting knockdown experiments of the seven Hox genes expressed during embryogenesis. Experimental results have demonstrated that Ci-Hox12 plays an important role in tail development through the maintenance of expression of Ci-Fgf8/17/18 and Ci-Wnt5 in the tail tip epidermis. Additionally, it has been shown that Ci-Hox10 is involved in the development of GABAergic neurons in the dorsal visceral ganglion. Surprisingly, knockdown of Ci-Hox1, Ci-Hox2, Ci-Hox3, Ci-Hox4 and Ci-Hox5 did not give rise to any consistent morphological defects in the larvae. Furthermore, expression of neuronal marker genes was not affected in larvae injected with MOs against Ci-Hox1, Ci-Hox3 or Ci-Hox5. In conclusion, we suggest that the contribution of Hox genes to the larval development of the ascidian C. intestinalis might be limited, despite the fact that Ci-Hox10 and Ci-Hox12 play important roles in neuronal and tail development.
Orbifolds of symplectic fermion algebras

We present a systematic study of the orbifolds of the rank n symplectic fermion algebra A(n), which has full automorphism group Sp(2n). First, we show that A(n) andA(n) areW-algebras of typeW(2, 4, . . . , 2n) andW(2, 3, . . . , 2n+1), respectively. Using these results, we find minimal strong finite generating sets for A(mn) and A(mn) for all m,n ≥ 1. We compute the characters of the irreducible representations of A(mn)Sp(2n)×SO(m) and A(mn)GL(n)×GL(m) appearing inside A(mn), and we express these characters using partial theta functions. Finally, we give a complete solution to the Hilbert problem forA(n); we show that for any reductive groupG of automorphisms,A(n) is strongly finitely generated.
Pharmacokinetic drug–drug interaction assessment between LCZ696, an angiotensin receptor neprilysin inhibitor, and hydrochlorothiazide, amlodipine, or carvedilol

LCZ696 is a first‐in‐class angiotensin receptor neprilysin inhibitor in development for treatments of hypertension and heart failure indications. In 3 separate studies, pharmacokinetic drug–drug interactions (DDIs) potential was assessed when LCZ696 was coadministered with hydrochlorothiazide (HCTZ), amlodipine, or carvedilol. The studies used a open‐label, single‐sequence, 3‐period, crossover design in healthy subjects. Blood samples were collected to determine the pharmacokinetic parameters of LCZ696 analytes (AHU377, LBQ657, and valsartan), HCTZ, amlodipine, or carvedilol (R[+]‐ and S[−]‐carvedilol) for statistical analysis. When coadministered LCZ696 with HCTZ, the 90% CIs of the geometric mean ratios of AUCtau,ss of HCTZ and that of LBQ657 were within a 0.80–1.25 interval, whereas HCTZ Cmax,ss decreased by 26%, LBQ657 Cmax,ss increased by 19%, and the AUCtau,ss and Cmax,ss of valsartan increased by 14% and 16%, respectively. Pharmacokinetics of amlodipine, R(+)‐ and S(−)‐carvedilol, or LBQ657 were not altered after coadministration of LCZ696 with amlodipine or carvedilol. Coadministration of LCZ696 400 mg once daily (qd) with HCTZ 25 mg qd, amlodipine 10 mg qd, or carvedilol 25 mg twice a day (bid) had no clinically relevant pharmacokinetic drug–drug interactions. LCZ696, HCTZ, amlodipine, and carvedilol were safe and well tolerated when given alone or concomitantly in the investigated studies.
The effect of CD14 C159T polymorphism on in vitro IgE synthesis and cytokine production by PBMC from children with asthma

To cite this article: Sackesen C, Birben E, Soyer OU, Sahiner UM, Yavuz TS, Civelek E, Karabulut E, Akdis M, Akdis CA, Kalayci O. The effect of CD14 C159T polymorphism on in vitro IgE synthesis and cytokine production by PBMC from children with asthma. Allergy 2011; 66: 48–57.
Prospective evaluation of the macroscopic types and location of early Barrett's neoplasia in 380 lesions.

BACKGROUND AND STUDY AIMS The macroscopic appearance of early gastric cancers, classified according to the Japanese criteria, has been shown to be an important prognostic factor for local endoscopic therapy. No prospective data about the distribution of macroscopic types and their location in early Barrett's neoplasia are available, however. The present study was conducted to evaluate the clinical applicability of this macroscopic classification and to analyze the relative proportions of the different gross types in early Barrett's neoplasms and the correlation between the macroscopic classification and the stage or grade of differentiation. PATIENTS AND METHODS A total of 344 patients with 380 Barrett's neoplastic lesions who were referred between October 1996 and September 2005 for endoscopic therapy of early Barrett's high-grade intraepithelial neoplasia and carcinoma were prospectively included in the study. Routine endoscopy prior to endoscopic resection in our center included assessment of the macroscopic type (according to the Japanese classification) and documentation of the radial location of the neoplastic lesions. Images were recorded which were later assessed by six independent reviewers; intra- and interobserver agreement for the assessment of the macroscopic type were calculated using kappa statistics. RESULTS The distribution of the lesions by gross type was as follows: type I, n = 49 (13 %); type IIa, n = 139 (37 %); type IIb, n = 106 (28 %); type IIc, n = 17 (4 %); type IIa + c, n = 62 (16 %); type III, n = 7 (2 %). Type IIb lesions seem to be the most favorable type with regard to differentiation and T category ( P < 0.05). The mean kappa value for the interobserver agreement was 0.86 and the mean kappa value for the intraobserver agreement was 0.89. Most lesions were found at the 12 o'clock and 3 o'clock positions. CONCLUSIONS Assessment of the macroscopic type may provide important information about the possibility of endoscopic treatment. The harder-to-detect flat lesions are by far the most frequent macroscopic type of neoplastic lesion in Barrett's esophagus.
Requirements for Heterodimerization between the Orphan Nuclear Receptor Nurr1 and Retinoid X Receptors*

The nuclear receptor nurr1 is a transcription factor involved in the development and maintenance of neurons synthesizing the neurotransmitter dopamine. Although the lack of nurr1 expression has dramatic consequences for these cells either in terms of differentiation or survival, the mechanisms by which nurr1 controls gene transcription still remain unclear. In the intent to understand better the modalities of action of this nuclear receptor, we have undertaken a systematic analysis of the transcriptional effects and DNA binding properties of nurr1 as a monomer or when forming dimers with the different isotypes of the retinoic X receptor (RXR). Here, we show that nurr1 acts as a gene activator independently of RXR and through an AF2-independent mechanism. In addition, heterodimerization with RXR is isotype-specific, involves multiple domains in the C-terminal region of nurr1, and requires RXR binding to DNA. RXRα-nurr1 and RXRγ-nurr1 heterodimers bind direct repeat response elements and display no specific requirements with respect to half-site spacing. However, the retinoid responsiveness of DNA-bound heterodimers requires the reiteration of at least three nurr1 binding sites, thereby limiting retinoid-induced nurr1 transcriptional activity to specific direct response elements.