Miracle-dz/UniFAR-FTUs huggingface dataset:
Targeting myocardial reperfusion injuries with cyclosporine in the CIRCUS Trial – pharmacological reasons for failure

The mitochondrial permeability transition (mPTP) is a key feature of cardiac cell death in ischaemia‐reperfusion injury (I/R). The mPTP blocker, cyclosporine A (CsA), has been shown to give protection against reperfusion‐induced myocardial necrosis and troubles generated by acute coronary artery repermeabilization. Nevertheless, the results of the CIRCUS trial (Does Cyclosporine Improve Clinical Outcome in ST‐Elevation Myocardial Infarction Patients) seem to go against this hypothesis. Pharmacological reasons linked to CsA pharmacokinetics and pharmacodynamics could be suggested. First, it could be explained by a limited diffusion of the drug in the area at risk, due to the only inclusion of patients with a TIMI 0 or 1 coronary blood flow in the anterior territory and the absence of collateral perfusion. Second, to explain a low tissue diffusion of the compound, blood cell capture and high metabolism could be suggested. Moreover, CsA is highly metabolized by cytochrome P450 3A4 (CYP3A4), a polymorphic enzyme leading to variations of Cmax and AUC between 10–20% in patients using CsA. Finally, CsA blocks calcineurin, a protein implied in I/R damage but calcineurin inhibition could contribute to protection towards I/R damage only when Rcan1, a calcineurin natural inhibitor, expression is low. The results of the CIRCUS trial are disappointing and could contribute to the withdrawal of the mPTP blockade pharmacological strategy as a way to protect the myocardium from I/R lesions. Nevertheless, many pharmacological insights could have contributed to an increased variability and, as a consequence, an important reduction of the pharmacological power of the study.
Comment des filles et des garçons de terminales littéraires ou scientifiques évaluent-ils et justifient-ils leurs sentiments d’efficacité personnelle ?

L’etude presentee ici s’inscrit dans le cadre de la theorie sociale cognitive developpee par Bandura. Elle s’interesse plus particulierement aux types de justifications que les filles et les garcons de terminales litteraires et scientifiques peuvent emettre a propos de leurs sentiments d’efficacite personnelle (SEP) vis-a-vis d’activites concretes. L’analyse de l’auto-evaluation et du discours de 32 eleves montre a la fois un effet du sexe et de la section suivie sur l’efficacite personnelle percue et sur le type de justifications enonce.
Exploring Beliefs about Pain and their Relationship with Treatment Recommendations: A Pilot Online Survey for Occupational Therapists

Background: Previous research has suggested that an association exists between clinician held beliefs about pain and clinicians’ treatment recommendations for clients with chronic low back pain. Such treatment recommendations are more likely to lessen the activity demands on clients and conflict with best practice guidelines for chronic low back pain. While it seems clinician held ‘fear avoidance beliefs’ could be important for treatment outcome, no research has been carried out on these beliefs in occupational therapists. Purpose: The purpose of this pilot study was to administer an online survey to explore New Zealand occupational therapists’ beliefs about pain, and their association with treatment recommendations for clients with low back pain. The use of an online survey was innovative: there is no published research on the use of such methods within the New Zealand occupational therapy workforce. Methods: An online survey was developed and tested. This included demographics, two fear avoidance beliefs questionnaires, a video case study of a client with chronic low back pain, and a series of questions about treatment recommendations for the ‘case’. An invitation to complete the survey was emailed directly to targeted occupational therapists, and to those receiving the New Zealand Occupational Therapy Board email newsletter. Results: Sixty-three online surveys were completed. The study found that there was a statistically significant positive association between ‘fear avoidance beliefs’, held by respondents, and the recommendation of home help for the case study. The response rate was approximately 8%, from emailing respondents directly, and 0.5%, from the New Zealand Occupational Therapy Board Newsletter. Feedback on the online survey process, including the use of video for the case study, was positive.
Malaria Related Knowledge, Practice and Behavior of People in South Halmahera, Indonesia. -

Eastern parts of Indonesia are well known as malaria high incidence areas. This study aimed to describe malaria-related knowledge, practices and behavior in high endemic areas of malaria in South Halmahera district. This descriptive study used probability proportional to measure method for cluster selection in study areas i.e., West Gane (WG) and East Gane (EG) sub-districts. Each area, there were 15 clusters, 405 households (HH), and maximum 2025 respondents (5 from each HH) involved in the study. Knowledge, practice, and behavior of people related to malaria were assessed using a standardized questionnaire. Field workers were trained and by using Personal Digital Assistance entered answers from respondent directly. Results revealed that totally there were 4050 respondents ranged from below five until above 50 years old. From those above 5 yr old who knew about malaria (86.7%), only 45.5% knew that malaria was caused by mosquito and 54.5% knew that mosquito bite inside and outside of the house. Knowledge on symptoms and treatments were relatively low particularly in EG compared to WG (33.7% vs. 74.0% and 19.2% vs. 58.5%, respectively for symptoms and treatment). In addition, most of those who knew malaria said that they agreed malaria is a dangerous disease and they could be infected but only 40.5% knew how to treat. Out of 810 HH, only 49.0% used bed net but only 63.5% consistently used the bed net every night. In addition, mosquito coil was used more in WG than in EG (43.4% vs. 1.9%). Conclusion: We conclude that knowledge, practice, and behavior about malaria were very low especially in EG. Health education should be prioritized as indispensable activity in malaria controlling program.
“Andere Zeiten, andere Lautgesetze”. Replica a Raffaele Caldarelli

Mario Enrietti “Andere Zeiten, andere Lautgesetze”. A Reply to Raffaele Caldarelli At first syllables in Slavic become open and then, because of the falling of jers, they go back to be closed again. These are two phenomena which take place in different stages and are not connected to each other.
PENGARUH KUALITAS PRODUK, HARGA, DAN KUALITAS PELAYANAN TERHADAP KEPUASAN PENGGUNA CAFE DAN RESTO CABANA MANADO

Persaingan yang semakin ketat menuntut para pelaku bisnis untuk memaksimalkan kinerjanya melalui kualitas produk, harga, dan kualitas pelayanan untuk dapat bertahan dalam persaingan bisnis dan mampu menciptakan kepuasan pelanggan. Tujuan penelitian ini adalah untuk mengetahui pengaruh kualitas produk, harga, dan kualitas pelayanan terhadap kepuasan pengguna Cafe dan Resto Cabana Manado. Jenis penelitian yang digunakan adalah penelitian asosiatif dan tekhnik analisis menggunakan regresi linear berganda. Hasil penelitian menunjukan bahwa kualitas produk, harga dan kualitas pelayanan berpengaruh positif terhadap kepuasan pengguna Cafe dan Resto Cabana Manado. Kualitas produk berpengaruh namun tidak signifikan terhadap kepuasan pengguna. Harga dan kualitas pelayanan berpengaruh signifikan terhadap kepuasan pengguna. Manajemen Cafe dan Resto Cabana Manado sebaiknya meningkatkan kualitas produk agar kepuasaan pengguna dapat selalu terpenuhi. Kata kunci : kualitas produk, harga, kualitas pelayanan, kepuasan pengguna
Electronic and Experimental Music: Technology, Music, and Culture

Electronic and Experimental Music: Technology, Music, and Culture is a revised and expanded edition of this classic work, providing a thorough treatment of the relevant history behind the marriage of technology and music that has led to the state of electronic music today. Beginning with an early history of electronic music before 1945, the book outlines key composers, inventions, and concepts, ranging from Edgard Varse to Brian Eno; musique concrte to turntablism; and compositional techniques used in both analog and digital synthesis. The third editions reader-friendly writing style, logical organization, and features provide easy access to key ideas, milestones, and concepts. Features: readers guides and summaries at the beginning and end of each chapter innovations boxes providing a unique profile of an influential individual in the field of electronic music listen playlists recommending key recordings in each musical genre mentioned in each chapter milestones timelines summarizing the major technological and musical innovations discussed in each chapter.
Plasma Levels of Neuropeptide Y and Peptide YY in Patients Diagnosed with Anorexia Nervosa and Type 2 Diabetes Morbid Obese Subjects

Anorexia Nervosa (AN) and Obesity are prevalent in modern societies. This study evaluate circulating levels of Neuropeptide Y (NPY) and of Peptide Tyrosine-Tyrosine (PYY) in 60 women: 20 affected by AN (Body Mass Index = BMI 15.74 ± 2.09 kg/m2, age 30.19 ± 10.52 yr), 10 restrictor (BMI 14.89 ± 1.64 kg/m2) and 10 binge-purge subtype (BMI 18.27 ± 0.81 kg/m2); 20 affected by severe Obesity (BMI>40 kg/m2; age 33.56 ± 5.2 yr) with type II diabetes with no therapy, and 20 healthy controls (BMI 22.06 ± 0.93 kg/m2, age 32.44 ± 4.35 yr). NPY is higher in AN than obese and controls (70.17 ± 20.84 vs 25.12 ± 7.26 and 52.20 ± 10.88 pmol/L; p<0.001) and lower in obese than controls (p<0.001). PYY is higher in AN than obese and controls (219.77 ± 83.51 vs 116.42 ± 41.42 and 94.97 ± 12.74 pg/ml; p<0.001), with no differences between obese and controls. In AN, NPY and PYY are quite higher (p=0.059; p=0.06) in restrictor (75.77 ± 20.86 pmol/L; 241.78 ± 84.6 pg/ml) than in binge-purge subtype (53.39 ± 8.72 pmol/L; 153.73 ± 29.45 pg/ml). Increase of NPY despite simultaneous PYY increase in AN might be related to reduced sensitivity to PYY inhibitory effect on NPY production or increased production of NPY from sympathetic peripheral nervous system, a finding evident mainly in restrictor AN. In obese PYY is close to controls suggesting a reduced intestinal production of this peptide because of the stimulus of continuous overfeeding, whereas the reduced NPY production could be explained by increased levels of insulin and leptin. Reduced NPY levels suggest that in these obese the overfeeding is not dependent on increased hungry signal, but on inadequate satiety signal.
A normal form for sets of not-necessarily normalized relations

A normal form for sets of not-necessarily normalized relations, called NF-N3, is defined. This normal form not only removes local redundancy within each single relation but also removes global redundancy among relations. Properties pertaining to this normal form are given. The main differences between this normal form and others are discussed. Two methods for obtaining sets of not-necessarily normalized relations that are in NF-N3 namely, a decomposition method and a method that uses the entity-relationship (ER) approach are given. A description is given of how the ER approach together with the concepts of a normal-form ER diagram and functional dependency theory can be used for designing a relational database schema that allows the existence of non-first-normal-form relations. The set of not-necessarily normalized relations generated is in NF-N3. The correspondence between not-necessarily normalized relations and hierarchical definition trees of hierarchical databases is presented. <<ETX>>
Rate Of Abnormal Coagulation Test Results in Patients with Congenital Heart Disease

Introduction: Coagluation abnormalities are expected in patients with congenital heart disease. We searched the rate of abnormal coagulation test in children with both cyanotic and non-cyanotic heart disease and investigated the clinical relevance of these abnormal tests. Material and Method: 49 children who have congenital heart disease and needed surgical intervention were prospectively enrolled to this study. Demographic data, primary diagnosis, bleeding complication during and after the intervention and prognosis of the patients were recorded. Platelet counts, prothrombin time, activated partial thromboplastine time and blood fibrinogen levels were measured prior to intervention. Results: 16 patients had prolonged PT, 13 patients had low fibrinogen level, 10 patients had prolonged aPTT and 5 patients had low platelet count. Conclusion: There was no increased complication risk in patients with abnormal test results, but caution must be taken during operation of these patients.
Eat, Drink and Be Civil: Sociability and the Cafe

The article investigates the ascendency of the cafe in the current period of urbanism. I suggest that “going for a coffee” is less about coffee and more about how we connect with others in a mobile world, when flexible work hours are increasingly the norm and more people are living alone than any other period in history. The cafe also plays a role in the development of civil discourse and civility, and plays an important role in the development of cosmopolitan civil societies.
MODEL PEMBELAJARAN REFLEKTIF UNTUK MENINGKATKAN PEMAHAMAN KONSEP DAN KEMAMPUAN KOMUNIKASI MATEMATIS : Studi Eksperimen di Suatu Sekolah Dasar di Bandung

Lusiana (2011) “Model Pembelajaran Reflektif untuk Meningkatan Pemahaman Konsep dan Kemampuan Komunikasi Matematis” (Studi Eksperimen di Suatu Sekolah Dasar di Bandung). ” Banyak siswa Indonesia mengalami kesulitan dalam memahami konsep matematis dan mengomunikasikannya. Penyebab utamanya terletak pada tata cara pembelajaran yang masih mengandalkan model pembelajaran konvensional. Penelitian ini dilaksanakan dengan tujuan mengkaji penerapan Model Pembelajaran Reflektif sebagai alternatif model pembelajaran untuk mengatasi permasalahan tersebut di atas. Melalui penelitian ini diperoleh bukti empiris bagaimana peningkatan pemahaman konsep matematis, kemampuan komunikasi matematis, kaitan (hubungan) antara pemahaman konsep dan kemampuan komunikasi matematis, dan bagaimana sikap siswa terkait dengan model pembelajaran ini. Subjek populasi dalam penelitian ini adalah siswa Sekolah Dasar (SD) Trimulia kelas V yang berlokasi di Kotamadya Bandung. Kelas penelitian terdiri dari kelas eksperimen dan kontrol kelas yang dipilih secara acak dengan kondisi kelas eksperimen diberi perlakuan Model Pembelajaran Reflektif sedangkan kelas kontrol diberi perlakuan model pembelajaran konvensional. Instrumen yang digunakan adalah tes pemahaman konsep matematis, tes kemampuan komunikasi matematis, angket sikap skala Likert, dan lembar observasi. Hasil analisis data menunjukkan bahwa peningkatan pemahaman konsep dan kemampuan komunikasi matematis siswa yang belajar dengan Model Pembelajaran Reflektif lebih baik daripada siswa yang belajar dengan model pembelajaran konvensional. Juga terdapat kaitan yang tinggi antara pemahaman konsep dan kemampuan komunikasi di kelas eksperimen dan sedang di kelas kontrol. Berdasarkan angket, siswa secara umum berpendapat bahwa model pembelajaran dengan serangkaian kegiatan yang ada di dalamnya ini berpengaruh positif terhadap kompetensi (pemahaman konsep dan kemampuan komunikasi) yang dikembangkan dalam penelitian ini.
Central Sleep Apnea

Central sleep apneas result from an abolition of centrally generated rhythmic inspiratory activity, and they are characterized by a cessation of airflow at the nose and mouth along with the cessation of inspiratory thoracoabdominal excursions (Figs. 1, 2) as opposed to obstructive (Fig. 1) and mixed apneas (Fig. 2) both of which are characterized by the presence of occluded inspiratory efforts during their course. ' Arbitrarily, such respiratory pauses during sleep have to last at least 10 seconds to qualify as an apnea. Apnea occurrence during sleep does not necessarily indicate a specific abnormality of respiratory control or an underlying disease process per se, since they may be observed in normal asymptomatic persons with varying duration and frequency ,3-13 and in patients with different clinical characteristics. In this respect they may be likened to premature atrial and ventricular contractions, which do not necessarily indicate the presence of underlying organic heart disease. Thus, central sleep apneas should be accepted as a clinical finding that needs to be interpreted in view of their characteristics, the associated symptomatology and other clinical findings, and their pathophysiologic consequences, such as arterial oxygen desaturation, alveolar hypoventilation, and sleep fragmentation.
A comparative study of thiopental and thiopental– propofol admixture with xylazine premedicated donkeys

The anesthetic property between thiopental (T) and thiopental–propofol mixture (TP) was evaluated in six adult donkeys premedicated with xylazine (X) . Each donkey was anesthetized one time with each dose of (T) (10 mg/kg) and (TP)(5mg/kg+1mg/kg, intravenous respectively) five minutes later of premedication with (X) (1 mg/kg, I.V.). The following anesthetic parameters; induction of anesthesia, duration and quality of anesthesia, narcosis and standing time after recovery, heart and respiratory rates, were qualitatively and quantitatively assessed. The results did not show any significant difference at the level of (p<0.05) between both anesthetic protocols. But, clinically, anesthesia with (T) produce rapid, smooth, and free of excitement induction (18.50 ± 9.88 sec) with apnea (25 ± 8.8 sec). Thiopental produced anesthesia characterized by; good muscle relaxation, narcosis (30.50 ± 5.42 min) and surgical anesthesia (20.25 ± 3.47 min). Recovery was smooth and the standing time lasted for (35.50 ± 10.53 min). While anesthesia with (TP) characterized by a smooth induction (37.75 ± 11.44 sec) and without apnea, good muscle relaxation, and the duration of anesthesia (17.7 ± 1.03 min) and narcosis (23.25 ± 0.62min) was shorter than (T). Recovery was smooth and standing time after recovery was longer than (T) (47.50 ± 12.66 min). In conclusion, both protocols produced good anesthesia in donkeys, but (TP) anesthesia may be a clinically usable technique for induction of anesthesia in donkeys. نیزلایازلاب ةلماعملا ریمحلل لوفوبوربلاو لاتنبویاثلا جیزمو لاتنبویاثلا ریثأت ةنراقم ةسارد دبع ماسو ينایحلا فسوی اللها دیلوتلاو ةحارجلا عرف يرطیبلا بطلا ةیلك / ةعماج رابنلأا
Wanita dan Rokok

Keinginan untuk merokok lebih besar pada wanita daripada pria karena wanita lebih cepat merasa gelisah/kalut dan lain-lain. Beberapa orang wanita yang ''fashionable" berpendapat dengan merokok mereka akan tetap langsing. Di daerah perkotaan kebiasaan merokok pada wanita mungkin dijadikan simbol modemisasi wanita dan diperkirakan kecenderungannya akan meningkat dari tahun ke tahun, maka masalah ini perlu mendapat perhatian secara khusus. Beberapa efek negatif merokok yang berlaku pada pria juga berlaku pada wanita, namun adanya perbedaan struktur tubuh wanita dengan pria menyebabkan timbulnya efek khusus yang tidak terdapat pada pria.
The Association between Smoking, Alcohol Intake, and Low-Salt Diet: Results from the 2008 Community Health Survey

ABSTRACT The purpose of this study was to identify the association between health-related behaviors including smok-ing, alcohol intake, and the practice of a low-salt diet using data from a Community Health Survey conducted in 2008. The study subjects were 129,151 persons (19 years and older) without cardiovascular diseases or dia-betes mellitus diagnosis history. An index for evaluating low salinity was created by summing three low sal-inity-related questions (range: 0∼3), and a low-salt diet was defined if the index of low salinity was 3. We examined the levels of smoking and alcohol intake according to the index of low salinity, and conducted multiple logistic regression analysis to examine the odds ratios of low-salt diet practice in relation to smoking and drinking behavior, adjusting for general characteristics. The smoking and drinking status significantly im-proved as the level of low salinity index increase. Adjusting for general characteristics, those with smoking, alcohol intake, or a combined habit of the two behaviors had significantly lower odds ratios for practice of a low-salt diet. In conclusion, smoking and drinking behavior were negatively associated with the practice of a low-salt diet. Based on these findings, it may be necessary to have comprehensive nutritional education pro-grams that consider the multiple effects of smoking, drinking, and a low-salt diet.
Street Dreams and Hip Hop Barbershops: Global Fantasy in Urban Tanzania

AcknowledgmentsIntroduction: Popular Practices and Neoliberal Dilemmas in Arusha 1. Themes and Theories: Popular Culture in Africa and Elsewhere 2. Enacting the Invincible: Youthful Performance in Town Portraits 1: Bad Boyz Barbers 3. Thug Realism: Inhabiting Spaces of Masculine Fantasy Portraits 2: Aspiration 4. The Barber in Pain: Consciousness, Affliction, and Alterity Portraits 3: Uncertain Prospects 5. Gender (In)Visible: Contests of Style 6. Learning from Your Surroundings: Watching Television and Social Participation 7. Chronic Mobb Asks a Blessing: Apocalyptic Hip Hop and the Global Crisis ConclusionNotes References Index
Understanding Chinese hospitality management master's students' satisfaction with their education

This is to certify that the thesis/dissertation prepared By Entitled For the degree of Is approved by the final examining committee: Chair To the best of my knowledge and as understood by the student in the Research Integrity and Copyright Disclaimer (Graduate School Form 20), this thesis/dissertation adheres to the provisions of Purdue University's " Policy on Integrity in Research " and the use of copyrighted material. ii 献给我的家人 和你 iii ACKNOWLEDGEMENTS I would never have been able to finish my thesis without the guidance of my committee members and the support of my family and friends. First, I want to express my deepest gratitude to my committee chairs, Dr. Annmarie Nicely and Dr. Howard Adler, for their inspiring assistance and valuable guidance. Their intelligent and fresh insights inspired me the most when I struggled in the middle of the research, their patience and care also allowed me to overcome many life difficulties. They helped me throughout the research and writing process. Also I want to thank Dr. Hugo Tang, my committee member, for his commitment to my thesis. He offered me numerous inspiring ideas and suggestions that have raised my thesis to a higher level. The Chinese Master's students who were my subjects also deserve my appreciation. Thanks to the Chinese Master's students in my research for their participation. Without their input, this thesis would not have been possible. Their cooperation and participation assured the quality of the thesis and motivated me to complete the present research. Second, love from my family is my motivation to set and achieve high goals in my life. Mostly importantly, I want to express my heartfelt thanks to my Mom, who makes all my success happen. She works diligently to support me spiritually and financially, I owe my happiness to her. In addition, my Aunt, Grandmother, and my Father are my iv sources of love to me. Their encouragement and unconditional support drive me this far; I am extremely grateful to them. Finally, I cannot express enough my appreciation to my friends at Purdue and in China for their support, encouragement, and care. They offered me endless emotional and financial support. The purpose of the present research was to understand Chinese students' expectations and experiences with their Master's education in hospitality-related programs in the U.S. Three groups of persons could potentially benefit from the results of the study: university administrators, professors, and graduate …