Miracle-dz/UniFAR-FTUs huggingface dataset:
Ingroup Love or Outgroup Hate (or Both)? Mapping Distinct Bias Profiles in the Population

Researchers have long argued that ingroup favoritism and outgroup derogation are separable phenomena that occur in different, meaningful combinations. Statistical methods for testing this thesis, however, have been underutilized. We address this oversight by using latent profile analysis (LPA) to investigate distinct profiles of group bias derived from ingroup and outgroup warmth ratings. Using a national probability sample of Māori (the indigenous people of New Zealand; N = 2,289) and Europeans (N = 13,647), we identify a distinct profile reflecting ingroup favoritism/outgroup derogation (Type III in Brewer’s typology of ingroup bias) in both groups (6.7% of Māori, 10.3% of Europeans). The factors associated with this type, however, differed between groups. Whereas ethnic identity centrality predicted membership for Type III for Māori, social dominance orientation predicted this type for Europeans. Thus, although both groups may express the same kind of bias pattern, the motivation underlying this bias varies by status.
Hydrogen Desorption Properties of LiBH4/xLiAlH4 (x = 0.5, 1, 2) Composites

A detailed analysis of the dehydrogenation mechanism of LiBH4/xLiAlH4 (x = 0.5, 1, 2) composites was performed by thermogravimetry (TG), differential scanning calorimetry (DSC), mass spectral analysis (MS), powder X-ray diffraction (XRD) and scanning electronic microscopy (SEM), along with kinetic investigations using a Sievert-type apparatus. The results show that the dehydrogenation pathway of LiBH4/xLiAlH4 had a four-step character. The experimental dehydrogenation amount did not reach the theoretical expectations, because the products such as AlB2 and LiAl formed a passivation layer on the surface of Al and the dehydrogenation reactions associated with Al could not be sufficiently carried out. Kinetic investigations discovered a nonlinear relationship between the activation energy (Ea) of dehydrogenation reactions associated with Al and the ratio x, indicating that the Ea was determined both by the concentration of Al produced by the decomposition of LiAlH4 and the amount of free surface of it. Therefore, the amount of effective contact surface of Al is the rate-determining factor for the overall dehydrogenation of the LiBH4/xLiAlH4 composites.
Stationary and ambulatory attention patterns are differentially associated with early temperamental risk for socioemotional problems: Preliminary evidence from a multimodal eye-tracking investigation

Abstract Behavioral Inhibition (BI) is a temperament type that predicts social withdrawal in childhood and anxiety disorders later in life. However, not all BI children develop anxiety. Attention bias (AB) may enhance the vulnerability for anxiety in BI children, and interfere with their development of effective emotion regulation. In order to fully probe attention patterns, we used traditional measures of reaction time (RT), stationary eye-tracking, and recently emerging mobile eye-tracking measures of attention in a sample of 5- to 7-year-olds characterized as BI (N = 23) or non-BI (N = 58) using parent reports. There were no BI-related differences in RT or stationary eye-tracking indices of AB in a dot-probe task. However, findings in a subsample from whom eye-tracking data were collected during a live social interaction indicated that BI children (N = 12) directed fewer gaze shifts to the stranger than non-BI children (N = 25). Moreover, the frequency of gazes toward the stranger was positively associated with stationary AB only in BI, but not in non-BI, children. Hence, BI was characterized by a consistent pattern of attention across stationary and ambulatory measures. We demonstrate the utility of mobile eye-tracking as an effective tool to extend the assessment of attention and regulation to social interactive contexts.
Sleep history affects task acquisition during subsequent sleep restriction and recovery

The aim of the present study was to examine if sleep amount prior to sleep restriction mediated subsequent task acquisition on serial addition/subtraction and reaction time (RT) sub‐tasks of the Automated Neuropsychological Assessment Metric. Eleven males and 13 females [mean (SD) age = 25 (6.5) years] were assigned to either an Extended [10 h time in bed (TIB)] (n = 12) or Habitual [Mean (SD) = 7.09 (0.7)] (n = 12) sleep group for 1 week followed by one baseline night, seven sleep restriction nights (3 h TIB) and five recovery nights (8 h TIB). Throughout baseline, restriction and recovery, mathematical and serial RT tasks were administered hourly each day (08:00–18:00 h). Math and serial RT throughput for each task (speed × accuracy product) was analysed using a mixed‐model anova with fixed effects for sleep group, day and time‐of‐day followed by post hoc t‐tests (Bonferroni correction). Math throughput improved for both groups during sleep restriction, but more so compared with baseline for the prior sleep Extended group versus the Habitual group during recovery. In sum, 1 week of sleep extension improved resilience during subsequent sleep restriction and facilitated task acquisition during recovery, demonstrating that nightly sleep duration exerts long‐term (days, weeks) effects.
Impact of Tetrazolium Ionic Liquid Thermal Decomposition in Solvothermal Reaction on the Remarkable Photocatalytic Properties of TiO2 Particles

Ionic liquids (ILs) could serve as a structuring agent, a solvent, or a source of dopant during solvothermal synthesis of semiconductors particles. To understand the role of IL during formation of TiO2 particles, it is necessary to study the stability of this IL in solvothermal synthesis conditions, as well as studying the surface properties of formed TiO2 particles. In view of this, the effect of the 2,3,5-triphenyltetrazolium chloride IL ([TPTZ][Cl]) thermal decomposition during the solvothermal reaction and IL content in the reaction system on photoactivity of TiO2 microparticles has been systematically investigated. The samples obtained by using [TPTZ][Cl] exhibited remarkable photocatalytic properties in phenol degradation reaction under visible light. HPLC analysis of the solvothermal reaction medium and X-ray photoelectron spectroscopy (XPS) analysis of TiO2 particles revealed that [TPTZ][Cl] was decomposed completely and was incorporated into the TiO2 lattice. Generally, increasing the reaction time (1, 4, 12, and 24 h) promoted the TiO2 microspheres formation, as well as raising the visible light-induced photocatalytic activity of the photocatalysts. Longer reaction time was also accompanied by an increase in the efficiency of 2,3,5-triphenyltetrazolium chloride decomposition. The properties of the photocatalysts were investigated by means of UV-VIS diffuse reflectance spectroscopy (DRS), BET surface area measurements, scanning electron microscopy (SEM), X-ray powder diffraction (XRD) analysis, and XPS.
Transient vs enduring distress in late pregnancy using the EPDS: a brief longitudinal exploratory study

ABSTRACT Background and Objective: The Edinburgh Postnatal Depression Scale (EPDS) is widely used to detect perinatal distress in women by one single administration. Recently, research has shown that during early pregnancy around half of the women scoring as ‘possibly depressed’ on the EPDS only have transient distress, when re-tested after few weeks. This finding may not occur if women are screened later in pregnancy, as their worries then may be more enduring; therefore an exploratory study was conducted to further investigate this issue. Methods: Pregnant women (N = 84) attending a public hospital in Italy completed the EPDS in their third trimester (x = 33 weeks) and again 8–42 days later (while still pregnant). They had not received professional mental health intervention in this time interval. Results: Approximately half of the women who initially scored high on the EPDS in late pregnancy no longer scored high just a few weeks later. Conclusions: Approximately half of women who initially score high on the EPDS when screened in pregnancy only have transient distress in both the second and third trimester. To label these women as being ‘possibly depressed’, and mixing them with women who show enduring distress, represents a possible weakness in research studies, and may also overburden clinical services. We would therefore recommend, as research and clinical practice, a second administration of the EPDS if a woman initially scores in the distressed range at any stage in pregnancy.
Characterization of liver T‐cell receptor γδ+ T cells obtained from individuals chronically infected with hepatitis C virus (HCV): Evidence for these T cells playing a role in the liver pathology associated with HCV infections

The pathogenic mechanisms involved in viral hepatitis are not completely understood. Evidence suggests that the pathology associated with hepatitis C virus (HCV) and hepatitis B virus (HBV) infections are a result of the immune response in the liver to these viruses. The livers of patients with viral hepatitis have been shown to contain elevated numbers of T cells expressing the γ/δ form of the T‐cell receptor for antigen (TCRγδ). In this study, we investigated whether liver biopsy specimens obtained from individuals with viral (HCV and/or HBV) or nonviral hepatitis contained TCRγδ+ T cells that could be expanded in vitro by cytokines. A high percentage of liver biopsy specimens obtained from HCV‐ and/or HBV‐infected individuals contained high numbers of TCRγδ+ T cells. In contrast, T‐cell lines generated from liver biopsy tissues obtained from individuals with nonviral hepatitis or from normal controls had no preferential expansion of TCRγδ+ T cells. Liver TCRγδ+ T‐cell lines from HCV‐infected individuals had high levels of non–major histocompatibility complex (MHC)–restricted cytotoxic activity against different targets including primary hepatocytes and produced interferon gamma (IFN‐γ), tumor necrosis factor α (TNF‐α), and interleukin 8 (IL‐8) following activation by anti‐CD3. Surprisingly, none of these liver TCRγδ+ T‐cell lines could recognize any of the structural or nonstructural proteins of HCV and had no cytotoxic activity against cells infected with recombinant vaccinia viruses expressing different HCV proteins. However, the crosslinking of CD81, which has been shown to bind HCV particles and E2, resulted in significant levels of IFN‐γ and TNF‐α production by liver TCRγδ+ T cells. These results suggest that TCRγδ+ T cells may play a role in the liver pathology of HCV infections. (HEPATOLOGY 2001;33:1312‐1320.)
A Critical E-box in Barhl1 3′ Enhancer Is Essential for Auditory Hair Cell Differentiation

Barhl1, a mouse homologous gene of Drosophila BarH class homeobox genes, is highly expressed within the inner ear and crucial for the long-term maintenance of auditory hair cells that mediate hearing and balance, yet little is known about the molecular events underlying Barhl1 regulation and function in hair cells. In this study, through data mining and in vitro report assay, we firstly identified Barhl1 as a direct target gene of Atoh1 and one E-box (E3) in Barhl1 3’ enhancer is crucial for Atoh1-mediated Barhl1 activation. Then we generated a mouse embryonic stem cell (mESC) line carrying disruptions on this E3 site E-box (CAGCTG) using CRISPR/Cas9 technology and this E3 mutated mESC line is further subjected to an efficient stepwise hair cell differentiation strategy in vitro. Disruptions on this E3 site caused dramatic loss of Barhl1 expression and significantly reduced the number of induced hair cell-like cells, while no affections on the differentiation toward early primitive ectoderm-like cells and otic progenitors. Finally, through RNA-seq profiling and gene ontology (GO) enrichment analysis, we found that this E3 box was indispensable for Barhl1 expression to maintain hair cell development and normal functions. We also compared the transcriptional profiles of induced cells from CDS mutated and E3 mutated mESCs, respectively, and got very consistent results except the Barhl1 transcript itself. These observations indicated that Atoh1-mediated Barhl1 expression could have important roles during auditory hair cell development. In brief, our findings delineate the detail molecular mechanism of Barhl1 expression regulation in auditory hair cell differentiation.
Menopause and FOXP3+ Treg cell depletion eliminate female protection against T cell-mediated Angiotensin II hypertension.

Hypertension severity increases in women after menopause. Although the immune system is necessary for the development of angiotensin II (Ang II) hypertension in males, we have shown that premenopausal females are protected from T-cell-mediated hypertension. The goals of the current study were to test the hypotheses that 1) female protection against T-cell-mediated Ang II-hypertension is eliminated following progression into menopause and 2) Tregulatory cells (Tregs) provide premenopausal protection against Ang II-induced hypertension. Rag-1-/- mice were treated with 4-vinylcyclohexe diepoxide to induce menopause, received 14-day Ang II infusion, and adoptive transfer of male CD3+ T cells, three weeks before Ang II infusion. In the absence of T cells, systolic blood pressure (SBP) responses to Ang II were similar to premenopausal mice (Δ12mmHg). After transfer of T cells, Ang II increased SBP in postmenopausal females (Δ28mmHg). A significant increase in renal F4/80+ macrophages, inflammatory gene expression and reduction in renal expression of MRC1, an M2 macrophage marker, accompanied the increase in SBP. Flow cytometric analysis identified that Tregs were significantly decreased in the spleen and kidneys of menopausal mice. In a validation study, Ang II with an anti-CD25 antibody, to deplete Tregs by 30%, induced a significant increase in SBP in premenopausal females. These results demonstrate that protection against T-cell-mediated Ang II-hypertension is eliminated once females enter menopause, suggesting a change in hormonal status upregulates macrophage-induced pro-inflammatory and T-cell-dependent responses. Further, we are the first to report that the T regulatory cells are required to suppress Ang II hypertension in premenopausal females.
Expression of ACE and ACE2 in individuals with diabetic kidney disease and healthy controls.

BACKGROUND Angiotensin-converting enzyme (ACE) 2 (ACE2) is expressed mainly in the heart and kidney and forms angiotensin-1-7 from angiotensin II. ACE2 might act in a counterregulatory manner to ACE. There is little information about renal ACE and ACE2 expression in human diabetic nephropathy. STUDY DESIGN Cross-sectional study. SETTING & PARTICIPANTS Kidney tissue from 20 patients with type 2 diabetes and overt nephropathy and 20 healthy kidney donors. PREDICTOR Diabetes status. OUTCOMES & MEASUREMENTS Renal expression of ACE and ACE2 assessed by means of immunohistochemistry and in situ hybridization. Correlation between ACE and ACE2 expression and levels of various biochemical parameters. RESULTS Decreased ACE2 and increased ACE expression in both the tubulointerstitium and glomeruli resulted in a significant (P < 0.001) increase in ACE/ACE2 ratio in patients with diabetes with overt nephropathy compared with controls, although ACE messenger RNA in the tubulointerstitium did not significantly increase. ACE/ACE2 ratio correlated positively with values for mean blood pressure, fasting blood glucose, serum creatinine, proteinuria, and hemoglobin A(1c) and inversely with estimated glomerular filtration rate (P < 0.001). LIMITATIONS Inclusion of small number of human renal biopsy specimens with structural distortion of cortical tissue. CONCLUSIONS The high ACE/ACE2 ratio in kidneys of patients with type 2 diabetes with overt nephropathy may contribute to renal injury.
Epidemiological study on hand, foot and mouth disease in Tongzhou District, Beijing, 2013–2017

Objective To study the epidemiological characteristics of hand, foot and mouth disease (HFMD) in Tongzhou District, Beijing between 2013 and 2017. Methods Data on HFMD infections from 1 January 2013 to 31 December 2017 were collected from the Notifiable Infectious Diseases Reporting Information System and analysed. Serotyping of enteroviruses from samples from patients with HFMD was undertaken using reverse transcription–polymerase chain reaction. Results A total of 15 341 patients with HFMD were reported and 32 patients (0.2%) were classified as having severe HFMD. The annual mean incidence rate of HFMD was 219.3/100 000 of the general population. The incidence and case-severity rates of HFMD generally decreased between 2013 and 2017. In the floating migrant population, the incidence and cases-severity rates of HFMD were significantly higher than in the local population. The peak incidence and severity-case rates were at 2 years of age and > 90% of patients were ≤5 years. Enterovirus A71 and Coxsackievirus A16 were the predominant pathogens in 2013–2017. Conclusions During the 5-year period 2013–2017, the incidence rate and case-severity rate of HFMD generally decreased in Tongzhou District, Beijing. The floating migrant population and children ≤5 years of age were at the highest risk of HFMD.
A Retrospective Study on Efficacy and Safety of Rivaroxaban and Dalteparin for Long-Term Treatment of Venous Thromboembolism in Patients with Lung Cancer

Background: Standard therapy for cancer-associated venous thromboembolism (VTE) is low-molecular-weight heparin. The use of direct oral anticoagulants for cancer-associated VTE has increased; however, their efficacy and safety in lung cancer patients remain unclear. Objectives: We examined the efficacy and safety of rivaroxaban compared with dalteparin for cancer-associated VTE in patients with primary lung cancer. Methods: A single-center retrospective study of 204 patients with primary lung cancer who were prescribed rivaroxaban (n = 131) or dalteparin (n = 73) for VTE was performed. The primary endpoint was a composite event including recurrence and major or clinically relevant nonmajor bleeding. Secondary endpoints included the incidence of recurrence, major and clinically relevant nonmajor bleeding, all-cause mortality, and bleeding or pulmonary embolism-related mortality. Results: The composite event occurred in 38 (29.0) and 12 (16.4%) patients in the rivaroxaban and dalteparin (p = 0.045) groups, respectively. The multivariate Cox proportional hazards model for age, Eastern Cooperative Oncology Group performance score, and bleeding risk factors revealed the rivaroxaban group showed a 1.176-fold composite event risk without statistical significance (0.595–2.324, p = 0.641). There was no statistically significant intergroup difference for the incidence of VTE recurrence (5.3% in the rivaroxaban group versus 2.7% in the dalteparin group, p = 0.495) and major or clinically relevant nonmajor bleeding (23.7% in the rivaroxaban group versus 13.7% in the dalteparin group, p = 0.089). There was no significant difference in the all-cause mortality rate (hazard ratio 0.864, 95% CI 0.624–1.196, p = 0.337). Conclusions: There was no difference in the safety and efficacy profile of rivaroxaban compared with dalteparin. Therefore, rivaroxaban may be a valuable treatment option for lung cancer-associated VTE.
Proposal of a new nodal classification for operable non-small cell lung cancer based on the number of negative lymph nodes and the anatomical location of metastatic lymph nodes

Abstract Lymph node metastasis is one of the most important prognostic indicators in patients with radically resected non-small cell lung cancer (NSCLC). This retrospective study aimed to compare the predictive value of metastatic lymph nodes (MNs), lymph node ratio (LNR), resected lymph nodes (RNs), and negative lymph nodes (NNs) with the currently used pathologic nodal (pN) staging category. We conducted a retrospective analysis of 1019 consecutive NSCLC patients treated with complete resection in a single institution. Prognostic values of various lymph node factors were evaluated by analysis of univariate and multivariate Cox proportional hazards model, and the results were compared with those using the location-based pN stage classification. The median follow-up duration was 47 months. During this period, 353 cases of cancer recurrence and 337 deaths were reported. Multivariate cox analysis indicated that both pN and NN categories were independent predictors of patient survival. The patients were divided into six groups on the basis of pN and NN categories. The survival rates of the groups were as follows: pN0, NN≥8, 81.4%; pN0, NN<8, 73.8%; pN1, NN≥8, 61.4%; pN1, NN<8, 54.2%; pN2, NN≥8, 48.4%; and pN2>1, NN<8, 35.0%. Comparison of the predictive values of the lymph node factors showed that the new N category was a more valuable prognostic factor in operable NSCLC. The combination of anatomically based pN stage classification and the number of MNs is an accurate prognostic determinant in patients with operable NSCLC which can be equal to 8th N category.
Reports of Neuropsychiatric Symptoms of Older Care Recipients by Their Family Members and Their Foreign Home Care Workers: Results From Triadic Data

Objectives: To evaluate reports of neuropsychiatric symptoms (NPS) per family members and round the clock foreign home care workers. Design, setting, and participants: A cross-sectional matched sample of family members, foreign home care workers, and care recipients. Measurements: Family members and foreign home care workers completed a measure of NPS. All 3 stakeholders provided a variety of demographic and clinical characteristics. Results: There was a low agreement between family members and foreign home care workers with regard to reports of depression and disturbing behaviors in care recipient and a good agreement with regard to reports of memory problems. In addition to care recipients’ characteristics, family members’ characteristics were primarily correlated with family members’ reports of NPS and foreign home care workers’ characteristics were primarily associated with foreign home care workers’ reports of NPS. Conclusions: Because much of the evaluation of NPS relies on reports of formal (ie, paid) and informal caregivers (ie, unpaid), clinicians should be aware of the fact that these reports are based in large part on the subjective perception of the caregiver.