Miracle-dz/UniFAR-FTUs huggingface dataset:
Développement et applications d'outils d'analyse métagénomique des communautés microbiennes associées aux insectes. (Bioinformatic tools and applications for metagenomics of microbial communities associated to insects)

Ces travaux de these reposent sur le double objectif de proposer des approches innovantes pour l’etude des relations entre un hote et son microbiote, et de les appliquer a la description fine de l’holobionte du puceron du pois par des donnees metagenomiques. Les relations symbiotiques faconnent le fonctionnement et l’evolution de tous les organismes, mais restent decrites de maniere imparfaite, notamment a cause de la difficulte a caracteriser la diversite genomique des partenaires microbiens constitutifs des holobiontes. L’essor des technologies de sequencage metagenomique revolutionne l’etude de ces systemes, mais pose egalement des problemes methodologiques pour analyser les jeux de donnees metagenomiques. La metagenomique est ici appliquee au puceron du pois, un modele d’etude des relations symbiotiques qui abrite une communaute bacterienne d’une complexite moderee, ideale pour developper de nouvelles approches de caracterisation de la diversite microbienne. Cette these vise a mieux decrire la communaute de symbiotes qu’abrite cet holobionte, notamment en distinguant les differents niveaux de variabilite genomique en son sein. Nous presentons une demarche pour l’analyse metagenomique d’holobiontes, qui repose d’abord sur l’assignation taxonomiques des lectures par alignement a des genomes de reference ou prealablement assembles, puis sur la recherche de variants genomiques. L’etude de genotypes complets de symbiotes permet de retracer l’histoire evolutive des relations hote-microbiote avec une resolution elevee. Chez le puceron du pois, nous mettons en evidence des niveaux et structures de diversite genomique differents selon les symbiotes, que nous proposons d’expliquer par les modalites de transmission ou l’histoire evolutive propre a chacun des partenaires microbiens. Dans un second temps, nous presentons donc une methode d’assemblage guide par reference en contexte metagenomique. Cette methode se deroule en deux temps : le recrutement et l’assemblage de lectures par alignement sur un genome de reference distant, puis l’assemblage de novo cible des regions manquantes, permis par des developpements complementaires apportes au logiciel MindTheGap. Comparativement a un assembleur metagenomique, cette methode permet l’assemblage d’un seul genome en un temps reduit, et permet de detecter d’eventuels variants structuraux sur le genome cible. Applique au puceron du pois, MindTheGap a realise l’assemblage du symbiote obligatoire \textit{Buchnera} en un seul contig, et a permis d’identifier differents variants structuraux du bacteriophage APSE. Ces travaux ouvrent la voie a la fois a une caracterisation plus precise des relations hote-microbiote chez le puceron du pois par des approches fonctionnelles et metaboliques, ainsi qu’a l’application des outils presentes a des systemes plus complexes.
Opted Out: A study of men and women who have left television news careers

This research reports the results of a qualitative study of former experienced television news journalists. The analysis of in-depth interviews reveals that female participants were more likely to leave their careers. The socialist feminist perspective suggests women‘s careers were inhibited by gender role expectations that conflicted with expectations of television news work. These conflicts were often found in the women‘s personal situations and reified in the organization of work. Men were more likely to leave their careers when they became dissatisfied with the work. Based on these interviews, the study suggests the television news industry should consider new models for work that will retain the experienced worker, particularly women.
Figurative frames: A critical vocabulary for images in information visualization

Critical analyses provide information visualization practitioners with insight into the range and suitability of different techniques for visualization. Theory provides the necessary models and vocabulary to deconstruct, explain and classify visualizations, allowing the analysis and comparison of alternate designs, and evaluation of their success. While the critical vocabulary for information visualization in general is well developed, the same cannot be said for ‘hybrid’ information visualizations which combine abstract representation of data with figurative elements such as illustrations. Figurative elements are widely used in information visualization in practice and are increasingly recognized as beneficial for memorability. However, the information encoded by a figurative image and how that information contributes to the overall content of the visualization lacks robust definition within visualization theory. To support critical analysis of hybrid visualization, we provide a model of the information content of a figurative image, which we call the figurative frame model. We use the model to classify hybrid visualizations along two dimensions: information density in the images (defined as the number of features and preserved measurements) and integration of figurative and abstract forms of representation. The new vocabulary for analysing hybrid visualizations reveals how the figurative images expand the expressiveness of information visualization by integrating descriptive and abstract information and allows the formulation of new measures of visualization quality which can be applied to hybrid visualizations.
Digital innovation: A review and synthesis

Organizations are under increasing pressure to apply digital technologies to renew and transform their business models. A great deal of research has examined specific phenomena, such as adoption antecedents and design methods. However, it is unclear what we know in totality, including what research streams exist, how they fit together, and fruitful opportunities for new knowledge development. We combine scientometric and systematic literature review methodologies to examine 7 dimensions of an adapted theoretical framework: initiation; development; implementation; exploitation; the role of the external competitive environment; role of internal organizational environment; and product, service, and process outcomes. From a macro perspective, we find vastly uneven coverage of research streams, diversity and diffusiveness of research, and knowledge and learning as an underlying conceptual pillar. Combined with our summary of each of the 7 research streams, these findings suggest several areas of future research, which we develop by identifying oppositions and tensions.
Qualitative Analysis of Common Belief of Rationality in Strategic-Form Games

We study common belief of rationality in strategic-form games with ordinal utilities, employing a model of qualitative beliefs. We characterize the three main solution concepts for such games, viz., Iterated Deletion of Strictly Dominated Strategies (IDSDS), Iterated Deletion of Boergers-dominated Strategies (IDBS) and Iterated Deletion of Inferior Strategy Profiles (IDIP), by means of gradually restrictive properties imposed on the models of qualitative beliefs. As a corollary, we prove that IDIP refines IDBS, which refines IDSDS.
Optimal online channel strategies for a hotel considering direct booking and cooperation with an online travel agent

This paper studies the channel strategies for a hotel considering alternative online distribution channels. The decision for the hotel involves whether to rely on direct booking via its official website or cooperating with an online travel agent (OTA), and if the latter is suggested, what business model to be adopted for the cooperation with the OTA. Three mathematical models, i.e., direct booking model, OTA merchant model, and OTA agent model, are developed to evaluate the costs and benefits in the three different cases. The negotiation process in the OTA agent model is studied by using the generalized Nash bargaining solution. The optimal decisions and profits are analyzed with respect to the values of key parameters. Results of numerical examples are discussed to show the implications of the established models.
Dissociation between Private and Social Counterfactual Value Signals Following Ventromedial Prefrontal Cortex Damage

Individuals learn by comparing the outcome of chosen and unchosen actions. A negative counterfactual value signal is generated when this comparison is unfavorable. This can happen in private as well as in social settings—where the foregone outcome results from the choice of another person. We hypothesized that, despite sharing similar features such as supporting learning, these two counterfactual signals might implicate distinct brain networks. We conducted a neuropsychological study on the role of private and social counterfactual value signals in risky decision-making. Patients with lesions in the ventromedial prefrontal cortex (vmPFC), lesion controls, and healthy controls repeatedly chose between lotteries. In private trials, participants could observe the outcomes of their choices and the outcomes of the unselected lotteries. In social trials, participants could also see the other player's choices and outcome. At the time of outcome, vmPFC patients were insensitive to private counterfactual value signals, whereas their responses to social comparison were similar to those of control participants. At the time of choice, intact vmPFC was necessary to integrate counterfactual signals in decisions, although amelioration was observed during the course of the task, possibly driven by social trials. We conclude that if the vmPFC is critical in processing private counterfactual signals and in integrating those signals in decision-making, then distinct brain areas might support the processing of social counterfactual signals.
A randomized trial comparing doxorubicin, cyclophosphamide, methotrexate with leucovorin rescue, vincristine, and cytarabine (ACOMLA), with doxorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin (CHOP-B) in the treatment of diffuse histiocytic lymphoma

Forty eight patients with previously untreated diffuse histiocytic*lymphoma (DHL) were treated prospectively with ACOMLA (hydroxydaunorubicin, cyclophosphamide, vincristine, methotrexate with leucovorin, and cytosine arabinoside) or CHOP-B (cylophosphamide, hydroxydaunorubicin, vincristine, prednisone, and bleomycin). Forty six of these patients were classified by the Lukes-Collins classification with the identification of 13 large cleaved follicular center cell, 7 large non-cleaved follicular center cell, 14 B-cell immunoblastic, 8 T-cell immunoblastic, and 4 large cell unclassified lymphomas. There was no difference in survival advantage between the two treatments. Overall complete response rate was 70% (with ACOMLA having a response rate of 68% and CHOP-B 71%). Of these, 4 of the ACOMLA patients and 3 of the CHOP-B patients have relapsed. Median follow-up time is 32 months. Median survival for all patients has not yet been reached. Drug toxicity was substantial with 3 drug related deaths. ACOMLA caused slightly more sepsis but the difference was not significant. Patients with follicular center cell (FCC) lymphomas had a significant survival advantage over patients with immunoblastic sarcomas (p=0.01). No difference in survival was found between the cleaved and non-cleaved FCC types. Age, sex, stage, site of involvement, or presence of symptoms were not significantly correlated with survival. Immunoblastic sarcomas (B and T cell types) appear to be more resistant to current chemotherapeutic regimens and may warrant more aggressive treatment.
An Operationalized Understanding of Personalized Learning

As referenced in the Every Student Succeeds Act and the National Educational Technology Plan, personalized learning is the new focus in many K–12 learning environments. Nonetheless, few people understand what personalized learning really means and even fewer can design and implement a personalized learning environment appropriate for all learners, especially learners with disabilities. This 18-month descriptive research study focused on identifying the design characteristics of personalized learning environments and the initial results of these environments. Findings indicate that personalized learning environments require more than technology, that the technology itself is simply a tool to support implementation. These personalized learning environments were highly learner self-regulated, had transparent and actionable near-real-time data, provided various structures for student voice and feedback, and integrated purposeful supports for embedding the principles of Universal Design for Learning at the cornerstone of practice. Personalized learning requires a shift in instructional practice on behalf of both the teacher and the learners. Implications for further research and practice are discussed.
REPORTED HEAD INJURY AND DISCIPLINARY RULE INFRACTIONS IN PRISON

We hypothesized that prison residents with brain injuy would have greater difficulty in following prison rules then residents without brain injury. To test grossly for brain injury, we administered a simple structured interview to 129 felons in the Protective Custody and Segregation Unit of a large Midwestern prison. To assess prison rule-following, we counted the disciplinary tickets accrued per day of stay for 41 "reported head injury" (RHI) and 41 reported "no head injury" (NI) residents. The RHI group averaged . 2132 and NI residents . 1373 disciplinary tickets per day. A t-test (t = 14.10, p < .001) supported the hypothesis of difference in ticket receipt frequency between the groups. Thus, RHI residents were involved in disciplinary infractions nearly twice as frequently as NI residents. While a simple interview must be used with caution, the results of this study have some important implications for resident rehabilitation and prison management.
Du droit à l'enfant au travail psychique de la parentalité : approche psychanalytique de la maternité lesbienne

Resume L’objectif de cet article consiste a presenter les donnees d’une etude clinique qui porte sur l’exploration des representations de la fonction parentale des couples lesbiens demandant l’insemination artificielle par donneur (iad). La reference a la litterature anglo-saxonne et francophone autour des differentes questions soulevees par l’homoparentalite, notamment celles qui ont preoccupe la communaute psychanalytique, nous a permis d’orienter l’analyse qualitative du materiel clinique (issu des entretiens realises avec trente-deux couples) autour de deux axes. D’une part, il s’agit de penser l’iad comme une experience qui introduit un paradoxe important pour le psychisme des sujets concernes, et d’autre part, d’analyser le travail psychique lie a l’acces a l’homoparentalite surtout a travers la question de l’assignation des places de la mere biologique et de la mere sociale. L’analyse de ces deux thematiques, illustree par la presentation des vignettes cliniques, donne acces a une reflexion metapsychologique autour de la notion de tiers et du concept de la bisexualite psychique en tant qu’elements centraux de ce travail psychique.
Lay community health workers and mental health services in low resource settings : Group interpersonal psychotherapy for caregivers of children affected by nodding syndrome in northern Uganda

The thesis is premised on a public mental health perspective, and is informed by my interest in working with and developing task shifting/sharing initiatives in low resourced settings. Based on my experience with nodding syndrome (NS), a mysterious neuropsychiatric illness affecting children in northern Uganda, I sought to answer questions relating to the roles and utilization of lay community health workers (LCHWs) within health systems in low and middle-income countries (LMICs). I use outcomes from research studies that employed varied methods including a systematic literature review, qualitative and quantitative methods. The burden and nature of mental health problems associated with NS, task shifting initiatives to deliver psychological treatments in LMICs, as well as key intervention outcomes relating to the contextualization and effectiveness of group interpersonal therapy (IPT-G) for caregivers and their children affected by NS are discussed. The positive impact of IPT-G on both the intended beneficiaries (caregivers and their children) and providers (LCHWs) informs my discussion about syndemic approaches to care, as a model for public mental health care that demands further research in LMICs. The thesis concludes with insights and recommendations on the need to include emic and etic perspectives in determining burden of mental illness or disease, utilization of LCHWs to deliver effective public mental health interventions within LMICs, the importance of systematic contextualization of evidence based treatments as a prerequisite to scale up, and the need for ‘dual’ generation and syndemic interventions to address children and adolescent mental health problems.
The relationship between family socio-economic status, family social support and adolescent physical activity

Despite health benefits and WHO recommendations the prevalence of physically inactive adolescents and children is continuously increasing. A great number of research have found a positive relationship between socio- economic status and chronic diseases and mortality rates. The aim of this study was to examine: 1) the association between parents socio-economic status and adolescent physical activity ; 2) to assess links between parents social support and adolescents’ physical activity. Participants were 3396 final year secondary school students from 33 randomly selected secondary schools from Zagreb. The study was conducted from April to June in school year 2015. /2016. Physical activity was measured using a short version of the International Physical Activity Questionnaire (IPAQ-SF). Socio-economic status and parents’ social support was assessed using questionnaires. Boys were significantly more physically active than girls. The results of the logistic regression analysis did not determine statistically significant association between the socio-economic status of the father, the mother, the parents, family social support and physical activity of the participants. Family social support and parent’s socio- economic status are not positively related to physical activity in Croatian adolescents.
La lactancia materna en la Comunidad Valenciana. Análisis multivariante de una encuesta a 6.400 lactantes

MT. Hernandez Aguilar, A. Munoz Guillen, JJ. Lasarte Velillas, C. Garcia Vera, C. Diaz Marijuan, J. Martin Calama Pediatra. Consultorio Auxiliar de Carretera de Artes. Valencia. Pediatra. Jefe de Seccion de Neonatologia. Hospital Infantil La Fe. Valencia. Pediatra. Centro de Salud de Zuera. Zaragoza. Pediatra. Centro de Salud Monzon Urbano. Monzon. Huesca. Pediatra. Seccion de Neonatologia. Hospital Infantil La Fe. Grupo de Lactancia de la S.V. P. Pediatra. Servicio de Pediatria. Hospital Obispo Ruiz Polanco, Teruel.
The effectiveness of milieu language strategies on the English language growth of Head Start children learning English as a second language

The current study explored the effectiveness of milieu language strategies on the English language growth over the course of a school year of children learning English as a second language. The four basic milieu language strategies; model, mand-model, time delay, and incidental teaching, can be embedded into daily routines and interaction to teach language skills to children within a supportive context. Three Head Start teachers and nine children, three native English speakers and six native Spanish speakers, participated in the school year-long study. The teachers received training and coaching to effectively implement the milieu strategies. The aim of this study was to examine how instructional strategies created and implemented from a special education perspective based on recommended teaching practices can be used with children learning English as a second language as a means of providing teachers with developmentally appropriate strategies and providing children learning English as a second language with consistent comprehensible input. This study recognizes that children with special needs and children learning English as a second language do not necessarily have similar cognitive abilities and learning needs. The current study sought to answer three questions: can preschool teachers implement milieu language strategies with fidelity, what is the impact of milieu language strategies on young children‘s English acquisition, and what are teachers‘ perceptions regarding milieu language strategies. A multiple baseline single subject and qualitative case study methodology was used. Results showed that teachers can implement the strategies with fidelity with on-going feedback and coaching. Milieu language strategies had a positive impact children‘s language growth. Teachers‘ perceptions of the milieu language strategies were mixed. Additional research is needed to determine the specific types of coaching needed to maintain intervention fidelity
The home environment of junior high school students in Hyogo, Japan – Associations with asthma, respiratory health and reported allergies

Associations between home environment factors and respiratory symptoms, and reported allergies among junior high school students in Kobe, Japan (N = 1048) were investigated in the present study. These were mutually adjusted for age, sex, type of school (private/local) and their significant exposures to the environment. Totally 13.4% of students reported to have doctor's diagnosed asthma, 9.9% had wheeze and 50.1% had attacks of daytime breathlessness during past 12 months, 25.7% of students reported that they had pollen allergy, 8.8% had cat allergy and 6.1% had dog allergy. Totally 29.4% of students were living in a wooden house and during past 12 months, 18% of students reported that their homes had signs of dampness, 38.2% of homes had window condensation in winter and 7.8% of homes had indoor painting. Window condensation was associated with wheeze (odds ratio (OR) = 1.54; 95% confidence interval (CI) 1.01–2.34), daytime breathlessness (OR = 2.02; 95% CI 1.56–2.63), airway infection during past 12 months (OR = 1.66; 95% CI 1.17–2.37), cat allergy (OR = 1.63; 95% CI 1.05–2.54); mould allergy (OR = 1.84; 95%CI 1.08–3.12) and pollen allergy (OR = 1.54; 95% CI 1.15–2.06). Recent indoor painting was associated with daytime breathlessness (OR 1.83; 95% CI 1.12–3.00), dog allergy (OR = 2.23; 95% CI 1.02–4.85) and mould allergy (OR = 2.43; 95% CI 1.14–5.17). Living in a wooden house was associated with dog allergy (OR = 2.17; 95% CI 1.18–4.00) and mould allergy (OR = 1.98; 95% CI 1.04–3.76). In conclusion, in Japanese homes, the window condensation in winter, recent indoor painting and living in a wooden house could contribute to the increased risk of respiratory symptoms and allergies for young Japanese school children.