Miracle-dz/UniFAR-FTUs huggingface dataset:
Blood pressure load, vascular permeability and target organ damage in primary hypertension.

BACKGROUND Target organ damage (TOD) is an often reversible subclinical condition that may precede major cardiovascular events in primary hypertensive patients. Furthermore, TOD has been shown to be a complex, multifactorial process which does not depend on blood pressure (BP) reduction alone. We therefore investigated the relationship between BP load, vascular permeability and the occurrence of TOD. PATIENTS AND METHODS Thirty-seven never-treated, nondiabetic hypertensive patients were enrolled. Albuminuria was measured as the albumin to creatinine ratio (ACR), left ventricular mass index (LVMI) was assessed by echocardiography, systemic vascular permeability was evaluated by transcapillary escape rate of albumin (TERalb), and BP was measured by means of 24-hour ambulatory BP monitoring. RESULTS Patients with microalbuminuria showed higher levels of body mass index (BMI) (p<0.034), 24-hour systolic BP levels (p<0.001), left ventricular mass index (LVMI) (p=0.003) and capillary permeability to albumin (p<0.005), as compared with normoalbuminurics. Increased BP load and vascular permeability were associated with higher LVMI (p=0.012) and with an increased risk of having microalbuminuria and/or left ventricular hypertrophy (Chi square=17.4; p<0.001). Logistic regression analysis showed that the risk of having at least 1 sign of TOD was 10-fold higher in patients with TERalb above the median, and almost 5-fold higher for each 10 mm Hg increase in systolic blood pressure. CONCLUSIONS Abnormal vascular permeability and increased BP load are potentially modifiable risk factors that are independently associated with the development of subclinical cardiac and renal damage.
Work-Based Learning and Work-Integrated Learning: Fostering Engagement with Employers.

Work-based learning and the inclusion of the world of work into tertiary students' learning lie at the heart of the Australian vocational education and training (VET) system. Despite the strong emphasis of work-based learning in post-secondary education, both VET providers and universities faces challenges when it comes to engaging industry and employers in these educational provisions. This research synthesis draws on the literature on work-based learning and work-integrated learning to identify how engagement with industry and employers can be fostered, and what the two sectors can learn from each other.
The effects of co-occurring ADHD symptoms on electrophysiological correlates of cognitive control in young people with Tourette syndrome.

Efficient cognitive control is implicated in tic control in young people with Tourette syndrome (TS). Attention-deficit/hyperactivity disorder (ADHD) frequently co-occurs with TS and is associated with impaired cognitive control. Young people with TS and ADHD (TS+ADHD) show poorer cognitive control performance than those with TS, but how co-occurring ADHD affects underlying neural activity is unknown. We investigated this issue by examining behavioural and event-related potential (ERP) correlates of cognitive control in young people with these conditions. Participants aged 9-17 with TS (n = 17), TS+ADHD (n = 17), ADHD (n = 11), and unaffected controls (n = 20) performed a visual Go/Nogo task during electroencephalography (EEG) recording. Behavioural performance measures (D-prime, RT, reaction time variability, post-error slowing) and ERP measures (N2, P3, error-related negativity (ERN), error positivity (Pe)) were analysed in a 2 (TS-yes, TS-no) × 2 (ADHD-yes, ADHD-no) factorial analysis to investigate the effects of TS, ADHD, and their interaction. The results of these analyses showed that ADHD was associated with poorer performance and reduced amplitude of all ERPs, reflecting widespread cognitive control impairments. Tourette syndrome was associated with slowed RTs, which might reflect a compensatory slowing of motor output to facilitate tic control. There was no interaction between the TS and ADHD factors for any behavioural or ERP measure, indicating the impairing effects of ADHD on behaviour and electrophysiological markers of cognitive control were present in TS+ADHD and that RT slowing associated with TS was unaffected by co-occurring ADHD symptoms.
Involvement of gag- and env-specific cytotoxic T lymphocytes in protective immunity to feline immunodeficiency virus.

Definition of the immunological mechanisms involved in protective immunity against lentiviral infections is crucial to the development of an effective vaccine. The induction of gag- and env-specific cell-mediated immune responses was studied in cats following vaccination with whole inactivated feline immunodeficiency virus (FIV). Cats were immunized by inoculation with three doses of paraformaldehyde-inactivated FIV, derived from the feline lymphoid cell line, FL-4, which is persistently infected with the Petaluma isolate of FIV. Autologous or allogeneic skin fibroblasts either infected with recombinant FIV gag- or env-vaccinia virus or pulsed with FIV env peptides were used as targets in chromium-51 release assays. Effector cells were fresh peripheral blood mononuclear cells. Following the third immunization, all vaccinated cats, but none of the control cats immunized with adjuvant alone, had detectable FIV env-specific lymphocytotoxicity in their peripheral blood. Two cats also exhibited gag-specific activity. There was no recognition of either allogeneic skin fibroblasts infected with recombinant vaccinia virus or autologous target cells infected with wild-type vaccinia virus, indicating the specificity and MHC-restricted nature of the response. Vaccinated cats, but not control cats, were protected from challenge with the homologous Petaluma isolate of FIV. Partial epitope mapping of the env-specific cytotoxic response was performed using overlapping 10-amino acid peptides from the env V3 domain of FIV. This response appeared to be directed at env peptide 1 (RAISSWKQRN) and env peptide 3 (QRNRWEWRPD), which lie adjacent to a beta-turn within the V3 domain. (ABSTRACT TRUNCATED AT 250 WORDS)
Multilevel Optimal Modulation and Dynamic Control Strategies for STATCOMs Using Cascaded Multilevel Inverters

A multilevel optimal modulation strategy was developed for static synchronous compensators (STATCOMs) using cascaded multilevel inverters. In this strategy, besides the minimized harmonic distortion level, the inverter units' fundamental output voltages are also equalized. Therefore, all the inverter units in each phase leg can equally share the exchanged active and reactive power with the utility grid. This greatly helps the DC-link voltages balancing control. A special gating-pattern swapping scheme was developed to further maintain the DC capacitors' charge balance and equalize the current stress of the switching devices. The modulation strategy also includes a redundant operation scheme and a transformer DC magnetization prevention scheme. The performance of the proposed strategy was compared with the conventional fundamental frequency modulation strategy. To implement a fast and robust control of reactive power, a nonlinear feedback linearization controller with a direct voltage control capability was employed. The scheme of modulation index controlling and the operating modulation index range are presented. The effects of the system uncertainties on the closed loop dynamic performance are also discussed. A plusmn30 kVAr 21-level STATCOM prototype was developed. All the modulation and dynamic control strategies were verified using the experimental results from the scaled prototype.
Spousal caregivers of dementia victims: longitudinal changes in immunity and health.

&NA; Providing long‐term care for a demented relative profoundly affects caregivers' lives. We assessed changes in depression, immune function, and health in 69 spousal caregivers who had already been caregiving for an average of five years and 69 sociodemographically matched control subjects. Between the initial sample (“intake”) and the follow‐up data collected an average of 13 months later, caregivers showed decrements relative to controls on three measures of cellular immunity. Caregivers also reported significantly more days of infectious illness, primarily upper respiratory tract infections. Caregivers had a much greater incidence of depressive disorders than controls, with 25% of caregivers meeting syndromal criteria at intake and 32% at follow‐up, compared with no cases among controls at intake and 6% at follow‐up. Caregivers who reported lower levels of social support at intake and who were most distressed by dementia‐related behaviors showed the greatest and most uniformly negative changes in immune function at follow‐up.
Update on antiretroviral treatment during primary HIV infection

Primary HIV-1 infection covers a period of around 12 weeks in which the virus disseminates from the initial site of infection into different tissues and organs. In this phase, viremia is very high and transmission of HIV is an important issue. Most guidelines recommend antiretroviral treatment in patients who are symptomatic, although the indication for treatment remains inconclusive in asymptomatic patients. In this article the authors review the main virological and immunological events during this early phase of infection, and discuss the arguments for and against antiretroviral treatment. Recommendations of different guidelines, the issue of the HIV transmission and transmission of resistance to antiretroviral drugs, as well as recently available information opening perspectives for functional cure in patients treated in very early steps of HIV infection are also discussed.
Clinical Features of Plasmodium Vivax Malaria

Background: Since its reemergence in 1993, a number of cases of Plasmodium vivax malaria have been reported in Korea. We analyzed the cases of malaria patients living in Chuncheon and its neighboring communities, to characterize its clinical manifestations and laboratory findings, and to identify any differences between our clinical findings and those of previous studies. Methods: We reviewed the clinical records of cases that were confirmed as malaria by peripheral blood smear at Chuncheon Sacred Heart Hospital from July 1998 to September 2001. Results: Forty-four cases were included in the study. All patients were infected with Plasmodium vivax, and presented with high fever; however, tertian fever developed in only 15 patients (35.7%). A number of cases showed various symptoms, which included headache, abdominal pain, nausea and vomiting. Of the 44 cases identified, 41 (93.2%) developed malaria between June and September. Thrombocytopenia was a prominent finding in 75% of the cases at diagnosis, but resolved during or after therapy. Other laboratory abnormalities such as, anemia, elevated transamines, coagulopathies, and elevated lactose dehydrogenase (LDH) were also noted. Cerebrospinal fluid (CSF), studies were performed in five cases, one of which showed pleocytosis in the CSF. Conclusion: We noted only 15 patients (35.7%) with tertian fever; the other patients showed variable fever patterns. Thrombocytopenia was the most prominent laboratory finding. Therefore, we suggest that malaria should be included in the differential diagnosis of febrile diseases with an onset between June to and September, regardless of the pattern of the fever.
Biliary Complications After Liver Transplantation Using Grafts from Donors After Cardiac Death: Results from a Matched Control Study in a Single Large Volume Center

Objective:To assess the incidence and impact of biliary complications in recipients transplanted from donors after cardiac death (DCD) at one single large institution. Background:Shortage of available cadaveric organs is a significant limiting factor in liver transplantation (LT). The use of DCD offers the potential to increase the organ pool. However, early results with DCD liver grafts were associated with a greater incidence of ischemic cholangiopathy (IC), leading to several programs to abandoning this source of organs. Methods:A retrospective analysis of a prospective database from April 2001 to 2010 focused on 167 consecutive DCD-LT. Each DCD transplant was matched with 2 brain death donors (DBD) grafts (n = 333) according to the period of transplantation. Primary outcome measures were biliary complications including the severity of complications, graft survival and patient survival. Minimum follow-up was 3 months. Results:Anastomotic stricture was the most common biliary complication (DCD = 30, 19% vs. DBD = 41, 13%). Most were treated endocoscopically (grade IIIa = 72%), whereas hepatico-jejunostomy (grade IIIb) was performed in 22%. Primary IC occurred in 4 (2.5%) recipients from the DCD group and was absent in the DBD group (P = 0.005). However, none of these patients required retransplantation. Patient and graft survival at 1, 3, and 5 years were similar between DCD and DBD groups (P = 0.106, P = 0.138, P = 0.113, respectively). Conclusions:The encouraging results with DCD-LT are probably due to the selection of DCD grafts and clear definition of warm ischemia.
Dispersion of repolarization and refractoriness are determinants of arrhythmia phenotype in transgenic mice with long QT

Enhanced dispersion of repolarization (DR) and refractoriness may be a unifying mechanism central to arrhythmia genesis in the long QT (LQT) syndrome. The role of DR in promoting arrhythmias was investigated in several strains of molecularly engineered mice: (a) Kv4.2 dominant negative transgenic (Kv4.2DN) that lacks the fast component of the transient outward current, Ito,f, have action potential (AP) and QT prolongation, but no spontaneous arrhythmias, (b) Kv1.4 targeted mice (Kv1.4−/−) that lack the slow component of Ito (Ito,s), have no QT prolongation and no spontaneous arrhythmias, and (c) double transgenic (Kv4.2DN×Kv1.4−/−) mice that lack both Ito,f and Ito,s, have AP and QT prolongation, and spontaneous ventricular tachyarrhythmias. Hearts were perfused, stained with di‐4‐ANEPPS and optically mapped. Activation patterns and conduction velocities were similar between the strains but AP duration at 75% recovery (APD75) was longer in Kv4.2DN (28.0 ± 2.5 ms, P < 0.01, n= 6), Kv1.4−/− (28.4 ± 0.4 ms, P < 0.01, n= 5) and Kv4.2DN×Kv1.4−/− (34.3 ± 2.6 ms, P < 0.01, n= 6) mice than controls (20.3 ± 1.0 ms, n= 5). Dispersion of refractoriness between apex and base was markedly reduced in Kv4.2DN (0.3 ± 0.5 ms, n= 6, P < 0.05) but enhanced in Kv1.4−/− (14.2 ± 2.0 ms, n= 5, P < 0.05) and Kv4.2DN×Kv1.4−/− (15.0 ± 3 ms, n= 5, P < 0.5) mice compared with controls (10 ± 2 ms, n= 5). A premature pulse elicited ventricular tachycardia (VT) in Kv1.4−/− (n= 4/5) and Kv4.2DN×Kv1.4−/− hearts (n= 5/5) but not Kv4.2DN hearts (n= 0/6). Voltage‐clamp recordings showed that Ito,f was 30% greater in myocytes from the apex than base which may account for the absence of DR in Kv4.2DN mice. Thus, dispersion of repolarization (DR) appears to be an important determinant of arrhythmia vulnerability.
Zidovudine with nevirapine for the prevention of HIV mother‐to‐child transmission reduces nevirapine resistance in mothers from the Western Cape, South Africa

In the Western Cape province of South Africa, an intensified regimen for the prevention‐of‐mother‐to‐child‐transmission‐of‐HIV consisting of zidovudine (AZT) from 34 weeks of pregnancy plus single dose (sd) nevirapine (NVP) during labor was instituted in 2004. The newborn baby receives a single dose of NVP and AZT for 7 days. Similar strategies in Thailand and Africa have been shown to be more effective in reducing transmission than NVP alone. The use of sd NVP only for the prevention‐of‐mother‐to‐child‐transmission‐of‐HIV has a high risk of inducing resistance (25–69%) with an average of 35.7% by a recent meta‐analysis and has been shown to adversely affect non‐nucleoside reverse transcriptase inhibitor (NNRTI)‐based antiretroviral therapy when initiated within 6 months. In this study the prevalence of resistance to NVP and AZT in mothers who had received the intensified regimen was measured. Specimens collected from mothers were genotyped by in‐house PCR and sequencing. In specimens obtained within 60 days of delivery, acquired NVP resistance mutations were detected in 13 of 76 patients (17.1%, 95% confidence interval: 8.7–25.6%), which appears to be lower than in studies with sd NVP alone (37.5%, 95% confidence interval: 23.0–50.6%). J. Med. Virol. 80:942–946, 2008. © 2008 Wiley‐Liss, Inc.
Meaning in Life and depressive symptoms: a person-oriented approach in residential and community-dwelling older adults

Objectives: In current society, an increasing population of older adults and a high prevalence of depressive symptoms in late life is noticeable. A possible protective resource is ‘Meaning in Life’. The objective of this study is to identify from a person-oriented view (a) Meaning in Life-profiles, based on Presence of Meaning and Search for Meaning dimensions, and (b) their associations with depressive symptoms. Methods: A sample of 205 residential older adults (M = 83.20 years, SD = 7.26) and 280 community-dwelling older adults (M = 75.98 years, SD = 4.76) completed questionnaires of Meaning in Life and depressive symptoms. First, cluster analyses examined potential Meaning in Life-profiles. Second, analyses of variance tested associations between these distinct profiles and depressive symptoms. Results: In both samples, three distinguishable profiles emerged, a ‘Low Presence Low Search’, a ‘High Presence High Search’ and a ‘High Presence Low Search’. Furthermore, older adults with a High Presence Low Search profile witnessed less depressive symptoms, compared to those with a Low Presence Low Search profile. Residential older adults within the High Presence High Search cluster scored in-between the two other clusters for depressive symptoms. However, community-dwelling older adults within this cluster reported similar levels of depressive symptoms as the High Presence Low Search group. Conclusion: Similar Meaning in Life-profiles were detected in residential as well as community-dwelling older adults. In both samples, older adults with a High Presence Low Search profile reported less depressive feelings, pointing to the importance of spontaneously experiencing Meaning in Life in this life stage.
Gas Exchange and C Allocation in Dunaliella salina Cells in Response to the N Source and CO2 Concentration Used for Growth

The halotolerant alga Dunaliella salina was cultured on 10 mM NH4+ or NO3- with air CO2 or 5% (v/v) CO2. Cells grown on NH4+ rather than NO3- were up to 17% larger in volume but had similar division rates. The photosynthetic K0.5 of dissolved inorganic C per cell was reduced, but the light- and CO2-saturated photosynthesis, dark respiration, and light-independent fixation rates were increased. The cells exhibited 2- to 5-fold greater activities of ribulose-1,5-bisphosphate carboxylase/oxygenase, phosphoenolpyruvate carboxylase and carboxykinase, and carbonic anhydrase and more soluble and ribulose-1,5-bisphosphate carboxylase/oxygenase protein. Chlorophyll and [beta]-carotene also increased by 30 to 70%. However, starch and glycerol decreased, indicating that C was reallocated from carbohydrates into protein and pigments by growth on NH4+. Algae cultured on air-CO2 rather than a high CO2 concentration were 44% smaller with 55 to 67% lower cell division rates and thus appeared C-limited, despite the operation of a CO2-concentrating mechanism. Cells cultured on air-CO2 had less protein and starch and 28% more glycerol, but the pigment content was unchanged. In only one growth regime was the cell glycerol concentration sufficient to maintain osmotic equilibrium with the external medium, indicating that an additional osmoticum was required. It appears that the N source, as well as the growth [CO2], substantially modifies photosynthetic and growth characteristics, light-independent C metabolism, and C-allocation patterns of D. salina cells.
Impression Management Activity in Vision, Mission, and Values Statements: A Comparison of Commercial and Charitable Organizations

Abstract: This article investigates the extent to which vision, mission, and values (VM&V) statements play a role in corporate identity management by commercial and charitable organizations. Impression management (IM) theory was used to analyze how these statements could influence stakeholders’ impressions of an organization. A qualitative empirical study was conducted to explore VM&V statements on the websites of 100 commercial and 100 charitable organizations, using content analysis to identify IM activity in the statements. The findings have implications for academics and managers, as there were evidently gaps between theory and practice. Many of the commercial and charitable organizations underutilized VM&V statements as corporate identity cues, and there is subsequently potential for greater use of these statements as part of corporate identity management by organizations in both sectors. Managers should also ensure that the influence of the statements on stakeholders’ impressions of the organization aligns with the desired corporate image.
Abnormal Cortical Cells and Astrocytomas in the Eker Rat Model of Tuberous Sclerosis Complex

Summary: Purpose: In patients with tuberous sclerosis complex (TSC), a wide range of neurologic abnormalities develop, including mental retardation and seizures. Brains from TSC patients are characterized by the presence of cortical tubers, large dysmorphic neurons, and abnormal cytomegalic cells. Although analysis of human TSC brain samples led to the identification of these abnormal cell types, very little is known about how these cells function. In an effort to model TSC‐associated CNS abnormalities (and ultimately to analyze the electrophysiologic properties of abnormal cells), we examined Eker rats carrying a Tsc2 mutation. Anatomic studies, including standard histologic stains and immunocytochemistry, were performed on young Eker rats exposed to a carcinogen in utero or aged untreated Eker rats (18–24 months old).
Revolution, Reform, and Status Inheritance: Urban China, 1949–19961

Do regime change and market reform disrupt patterns of intergenerational mobility? China's political trajectory is distinctive from that of other communist regimes in two ways. During its first three decades, the regime enforced unusually restrictive barriers to elite status inheritance. And during the subsequent market transition, unlike most of its counterparts, the Communist Party survived intact. Data from a multigeneration survey suggest that despite their obvious exclusion from the party and related administrative careers in the Mao era, certain prerevolution elites transmitted one type of elite status to their offspring to a surprising degree. Party elites, in contrast, were hit hard by radical Maoism but recovered quickly afterward, and their offspring inherited elite status at much higher rates.