Miracle-dz/UniFAR-FTUs huggingface dataset:
A dynamic analysis of the ventilatory response to hypoxia in man.

1. The dynamics of the ventilatory response to isocapnic hypoxia were studied in seven healthy subjects using four different levels of hypoxia, (inspired oxygen pressures, PI,O2 equal to 110, 100, 80 and 60 mmHg) successively increasing and decreasing stepwise. 2. Five such progressions were performed for each subject, corresponding to five different durations of the steps (t) ranging between 0.33 and 5.00 min. The overall duration of one test (T) was taken as the sum of the seven successive PI,O2 hypoxic steps (t) plus one step t of air breathing. Thus, the values of T ranged between 2.6 and 40.0 min. 3. End‐tidal CO2 pressure was maintained constant (+/‐ 1 mmHg) throughout the test by manipulation of inspired CO2 pressure. 4. We measured, as a function of T, (i) the magnitude of the loops formed by the ventilatory response curves (PA,O2‐VE) as measured by their surface area (S), (ii) the magnitude of ventilatory response to each rising hypoxic step, and (iii) the difference between resting VE and VE observed at PA,O2 equal to 50 mmHg (delta V50). On average, we found one maximum in absolute value of S at T = 8 min and one minimum at T = 12 min, along with two maxima of ventilatory response at T values of 8 and 24 min. 5. The same measurements were made on tidal volume response curves (PA,O2‐VT) and ventilatory frequency response curves (PA,O2‐f): on average we observed two non‐significant peaks in the progression with T of VT and S(VT) and two significant peaks in that of delta VT,50 for T = 8 and T = 24 min. No significant peak was observed in the progression with T of f curve parameters. 6. These results are discussed together with the current dynamic model of the ventilatory control system, which includes a central neural controller with no dynamics of its own and a linear response to chemoreceptor inputs. We discuss the physiological meaning of a negative loop area in relation to the previously described depressant effect of hypoxia upon the brain stem. 7. We conclude that the dynamics of the controlling neuronal network are responsible for the observed singularities which result from differential sensitivity properties of the controller. We propose the existence of discrete excitatory states of the controller as a possible explanation of the shape of the steady‐state response curve to hypoxia and of the loop variations.
Considerations on the role of olfactory input in avian navigation

ABSTRACT A large amount of data documents an important role of olfactory input in pigeon navigation, but the nature of this role is not entirely clear. The olfactory navigation hypothesis assumes that odors are carrying essential navigational information, yet some recent experiments support an activating role of odors. This led to an ongoing controversy. An important, often-neglected aspect of the findings on olfaction is that olfactory deprivation affects avian navigation only at unfamiliar sites. The orientation of anosmic birds at familiar sites remains an enigma; earlier assumptions that they would rely on familiar landmarks have been disproven by the home-oriented behavior of anosmic pigeons additionally deprived of object vision, which clearly indicated the use by the birds of non-visual, non-olfactory cues. However, if odors activate the establishing and enlarging of the navigational ‘map’ and promote the integration of local values of navigational factors into this map, it seems possible that such a process needs to occur only once at a given site, when the birds are visiting this site for the first time. If that were the case, the birds could interpret the local factors correctly at any later visit and orient by them. This hypothesis could explain the oriented behavior of birds at familiar sites, and it could also help to reconcile some of the seemingly controversial findings reported in the literature, where the effect of olfactory deprivation was reported to differ considerably between the various pigeon lofts, possibly because of different training procedures. Summary: If odors are required to activate the integration of local navigational factors into the map, it seems possible that such a process needs to occur only once at a given site.
Primary mediastinal lymphoma: diagnosis and treatment options

Primary mediastinal large B-cell lymphoma (PMBCL) is a unique B-cell lymphoma variant that arises from a putative thymic medulla B cell. It constitutes 2–4% of non-Hodgkin lymphomas and occurs most frequently in young females. PMBCL is characterized by a diffuse proliferation of medium-to-large B cells associated with sclerosis. Molecular analysis shows that PMBCL is a distinct entity compared to other types of diffuse large B-cell lymphomas. PMBCL is characterized by a locally invasive anterior mediastinal bulky mass. The combination of rituximab with CHOP/CHOP-like regimens followed by mediastinal radiation therapy (RT) is associated with a 5-year progression-free survival of 75–85%. However, the role of consolidation RT still remains uncertain. More intensive regimens, such as DA-EPOCH-R without mediastinal RT, have shown very promising results. The conclusive role of PET-CT scan requires prospective studies and there is hope that this may allow to de-escalate RT and accordingly yield reliable prognostic information.
Genetic linkage and association analysis in type 1 von Willebrand disease: results from the Canadian Type 1 VWD Study

Summary. Background: von Willebrand disease (VWD) is the most common bleeding disorder known in humans, with type 1 VWD representing the majority of cases. Unlike the other variant forms of VWD, type 1 disease represents a complex genetic trait, influenced by both genetic and environmental factors. Aim: To evaluate the contribution of the von Willebrand factor (VWF) and ABO blood group loci to the type 1 VWD phenotype, and to assess the potential for locus heterogeneity in this condition, we have performed genetic linkage and association studies on a large, unselected type 1 VWD population. Method: We initially collected samples from 194 Canadian type 1 VWD families for analysis. After the exclusion of families found to have either type 2 or type 3 VWD, and pedigrees with samples from single generations, linkage and association analysis was performed on 155 type 1 VWD families. Results and conclusion: The linkage study has shown a low heterogeneity LOD score of 2.13 with the proportion of families linked to the VWF gene estimated to be 0.41. Linkage was not detected to the ABO locus in this type 1 VWD population. In the family‐based association test, significant association was found between the type 1 VWD phenotype, the quantitative traits, VWF:Ag, VWF:RCo, and FVIII:C and the ABO ‘O’ and ‘A’ alleles and the VWF codon 1584 variant. There was also weak association with the −1185 promoter polymorphism and VWF:Ag, VWF:RCo, and FVIII:C plasma levels. These studies provide further evidence to support the role for genetic loci other than VWF and ABO in the pathogenesis of type 1 VWD.
Percutaneous lumbar mechanical disc decompression utilizing Dekompressor®: an update of current evidence.

BACKGROUND The primary goal of the surgical treatment of nerve root compression from a disc protrusion continues to be the relief of compression by removing the herniated nuclear material with open discectomy. However, poor results have been reported for contained disc herniations with open surgical interventions. In recent years, a number of minimally invasive nuclear decompression techniques for lumbar disc prolapse, protrusion, and/or herniation have been introduced, including the Dekompressor®. The efficacy of several alternative techniques, including the Dekompressor, automated percutaneous discectomy, and laser discectomy, has been described, but is not convincing. There is a continued paucity of evidence for all decompression techniques. OBJECTIVE The objective of this systematic review is to evaluate and update the literature describing the clinical effectiveness of Dekompressor, a high rotation per minute (RPM) device used in mechanical lumbar disc decompression. STUDY DESIGN A systematic review of the literature focusing on mechanical disc decompression with Dekompressor. METHODS The available literature on the use of percutaneous disc decompression (PDD) with Dekompressor to manage chronic low back and lower extremity pain was reviewed using the Cochrane Musculoskeletal Review Group criteria for randomized trials and the Newcastle-Ottawa Scale criteria for observational studies.The level of evidence was classified as good, fair, and limited or poor based on the US Preventive Services Task Force (USPSTF) system for grading the quality of evidence.Data sources included relevant literature identified through PubMed and EMBASE from 1966 through September 2012, and manual searches of the bibliographies of known primary and review articles. OUTCOME MEASURES Pain relief was the primary outcome measure. Secondary outcome measures were functional improvement, improvement of psychological status, opioid intake, and return to work. Short-term effectiveness was defined as one year or less. Long-term effectiveness was defined as greater than one year. RESULTS Only 5 studies were considered for inclusion. Of those, only 3 of them met inclusion criteria. Based on USPSTF criteria, the level of evidence for PDD with Dekompressor is limited. LIMITATIONS Paucity of high quality literature. CONCLUSION This systematic review found limited evidence for PDD with Dekompressor.
The Family Gap in Pay: New Evidence for 1967 to 2013

This paper provides new evidence on the family gap in pay—the differential in hourly wages between women with children and women without children—between 1967 and 2013, five decades that include important changes in women's employment, especially mothers’ employment, policy reforms as well as contrasting economic cycles. We use data from the Current Population Survey and adjust for selection into motherhood, by estimating ordinary least square models and (as a robustness check) applying augmented inverse probability of treatment weighting, using the standard doubly robust estimator. For women overall, we find a decline in the family gap over this period from 6 percent in 1967 and 1968 to about 1 percent in 2011 through 2013. However, results vary by marital status, education, race-ethnicity, immigration status, temporal flexibility, and occupation. The most striking difference we find is between mothers who are married and those who are not. The family gap declined for married mothers and was replaced by a positive wage differential in the most recent period, whereas for unmarried mothers, a wage gap persisted throughout the two decades, rising to a notable high of 10 percent in 1996 through 1998.
Clinical care in craniofacial microsomia: A review of current management recommendations and opportunities to advance research

Craniofacial microsomia (CFM) is a complex condition associated with microtia, mandibular hypoplasia, and preauricular tags. It is the second most common congenital facial condition treated in many craniofacial centers and requires longitudinal multidisciplinary patient care. The purpose of this article is to summarize current recommendations for clinical management and discuss opportunities to advance clinical research in CFM. © 2013 Wiley Periodicals, Inc.
Methyl Donor Status Influences DNMT Expression and Global DNA Methylation in Cervical Cancer Cells.

BACKGROUND Methyl donor status influences DNA stability and DNA methylation although little is known about effects on DNA methyltransferases. The aim of this study was to determine whether methyldonor status influences DNA methyltransferase (Dnmt) gene expression in cervical cancer cells, and if so, whether there are associated effects on global DNA methylation. MATERIALS AND METHODS The human cervical cancer cell line, C4 II, was grown in complete medium and medium depleted of folate (FM+) and folate and methionine (FM). Growth rate, intracellular folate, intracellular methionine and homocysteine in the extracellular medium were measured to validate the cancer cell model of methyl donor depletion. Dnmt expression was measured by qRT PCR using relative quantification and global DNA methylation was measured using a flow cytometric method. RESULTS Intracellular folate and methionine concentrations were significantly reduced after growth in depleted media. Growth rate was also reduced in response to methyl donor depletion. Extracellular homocysteine was raised compared with controls, indicating disturbance to the methyl cycle. Combined folate and methionine depletion led to a significant downregulation of Dnmt3a and Dnmt3b; this was associated with an 18% reduction in global DNA methylation compared with controls. Effects of folate and methionine depletion on Dnmt3a and 3b expression were reversed by transferring depleted cells to complete medium. CONCLUSIONS Methyl donor status can evidently influence expression of Dnmts in cervical cancer cells, which is associated with DNA global hypomethylation. Effects on Dnmt expression are reversible, suggesting reversible modulating effects of dietary methyl donor intake on gene expression, which may be relevant for cancer progression.
Deficiency of naive T cells in patients with sudden deafness.

BACKGROUND Although there are a number of reports concerned with the role of immunity in the sudden onset of progressive sensorineural hearing loss, there are few references dealing with the involvement of immune-mediated mechanisms in sudden deafness. OBJECTIVES To study the phenotype of peripheral blood lymphocytes in a group of patients with sudden deafness by use of 3-color flow cytometry. DESIGN The study was carried out prior to the start of steroid therapy. Fourteen patients underwent a follow-up study once steroid therapy had been completed. Prospective analysis, case-control. SETTING Tertiary case referral center, ambulatory and hospitalized care. PATIENTS Twenty-two patients (13 men and 9 women; mean age, 45.3 years) were compared with 14 healthy control subjects (9 men and 5 women; mean age, 36 years). Patients were divided in 2 groups according to their response to steroid therapy. RESULTS Decreased numbers of both CD4+ helper cells (38.4% vs 45.5%; P = .04) and CD8+ cytotoxic cells (17.5% vs 22.3%; P = .02) were observed in patients and compared with those in the control subjects, as well as reduced numbers of CD4+CD45RA+ cells (14.4% vs 29.3%; P = .01) and CD8+CD45RA+ naive cells (18.2% vs 25.4%; P = .04). In the group of patients with a good response to steroid therapy (group 1), a tendency toward normalization of the CD4+ (pretreatment, 38.6%; posttreatment, 44.6%), CD4+CD45RA+ (pretreatment, 15.2%; posttreatment, 21.7%), and CD4+CD45RO+ (pretreatment, 21.1%; posttreatment, 18.2%) cell counts was observed, with a slight decrease in the CD8+ population (pretreatment, 18%; posttreatment, 15.7%). However, in patients with a poorer response (group 2), while there were increases in the CD4+ (pretreatment, 38%, posttreatment, 50%) and CD4+CD45RA+ (pretreatment, 12.8%; posttreatment, 16.7%) cell counts after steroid therapy, there was a significant increment in the CD4+CD45RO+ memory cell count (pretreatment, 14.1%; posttreatment, 28.5%) and low CD8+CD45RA+ counts (pretreatment, 14.6%; posttreatment, 15.5%). No differences were observed in the numbers of B or natural killer cells or in the presence of activation antigens CD25 and HLA-DR when pretreatment and posttreatment levels were compared. CONCLUSION These results demonstrate significant abnormalities in the subpopulations of lymphocytes in patients with sudden hearing loss, suggesting the existence of immune-mediated responses in the inner ear as possible etiopathogenic factors in this entity.
Pneumonia in the Elderly: A Review of the Epidemiology, Pathogenesis, Microbiology, and Clinical Features

Pneumonia is a common and important disease in the elderly. The incidence is expected to rise as the population ages, and, therefore, it will become an increasingly significant problem in hospitals and the community. A comprehensive literature review was performed in order to look at the characteristics of pneumonia in the elderly population. In particular, the epidemiology, etiology and pathogenesis—including risk factors, microbiology, and clinical features—were evaluated. While aging causes physiological changes which make elderly patients more susceptible to pneumonia, it was found that comorbidities, rather than age, are also an important risk factor. The most common micro-organism responsible for pneumonia is Streptococcus pneumoniae, but other organisms need to be considered, depending on the environment of presentation. Elderly patients are more likely than younger adults to present with an absence of fever and an altered mental state. Nursing home residents tend to present with more atypical and less characteristic symptoms.
Carborane-based carbonic anhydrase inhibitors.

CA inhibitors: Human carbonic anhydrases (CAs) are diagnostic and therapeutic targets. Various carborane cages are shown to act as active-site-directed inhibitors, and substitution with a sulfamide group and other substituents leads to compounds with high selectivity towards the cancer-specific isozyme IX. Crystal structures of the carboranes in the active site provide information that can be applied to the structure-based design of specific inhibitors.
Reference Equation for Six Minute Walk Test in Healthy Western India Population.

INTRODUCTION The Six Minute Walk Test (6MWT) is used to assess disease progression and survival in chronic cardiopulmonary disorders. However, variability is noted in the six minute walk test distance (6MWD) in different populations. AIM We aimed to develop a reference equation for 6MWD in healthy Western India population and compare the results with previously published Indian and Caucasian reference equations. MATERIALS AND METHODS Total 174 healthy subjects between 25 to 75 years performed the 6MWT. Variables assessed were age, height, weight, body mass index and sex. Predicted equations were derived using multiple linear regression and compared with the equations for North Indian male, South Indian and Caucasian population using Bland - Altman method. RESULTS The 6MWD mean (SD) was 512.38 (67.84) m for men and 457.27 (56.75) m for women with p=0.001. The 6MWD correlated with age (r=-0.44), height (r=0.43), weight (r=0.21) in univariate analysis. Stepwise multiple regression analysis showed age and sex to be independent predictors of 6MWD, R(2) =0.307. The reference equation for healthy Western India population is 553.289 + (-2.11 x age) + (45.323 x sex; men=1 and women =0). Bland Altman analysis showed that the mean bias was 50.87m (95% limits of agreement 134.77 to - 33.0) for North Indian male equation, 50.75m (95% limits of agreement 105.72 to - 4.22) for South Indian equation and 122.72m (95%limits of agreement 254.11 to - 8.67) for Enright and Sherrill's equation. CONCLUSIONS The North Indian male, South Indian and Caucasian equations significantly over-estimated the predicted walk distance for our healthy population. Hence, there is a need to develop subgroup population specific reference equations.
Innovation, heterogeneous firms and the region: evidence from Spain

ABSTRACT Innovation, heterogeneous firms and the region: evidence from Spain. Regional Studies. This paper investigates the role of regional factors in innovation performance, controlling for firms’ absorptive capacity and other sources of firm heterogeneity. The findings for a sample of firms in Spain support the hypothesis that regional determinants matter, though their role is subtler than is frequently assumed. Rather than exerting a direct influence on firms’ innovation, the regional context moderates the effect of internal determinants, particularly of the firms’ absorptive capacity. The results indicate that the type of relevant interactions differs for product and process innovation and that they only operate for small and medium-sized enterprises, being negligible for large firms.
An assessment of automatic speech recognition as speech intelligibility estimation in the context of additive noise

This paper investigates the potential applicability of automatic speech recognition (ASR) and 6 well-reported objective quality measures for the task of ranking intelligibility of speech degraded by different real life background noises. In a recent investigation ASR has been reported to give high subjective correlation with human assessment when tested with various system degradations. This paper extends this investigation in two directions. First, the usefulness of the measures in the context of different real-life noises is considered. Second, the direct correspondence between statistics computed by an ASR system and human perceived intelligibility is assessed. Subjective listening tests are carried out to provide ground truth. Results show that ASR and WSS (weighted spectral slope) are the only two measures out of the seven considered to give good correlation with human opinion. Specially noted is performance of ASR with correlations ranging from 0.77 to 0.90. Index Terms: speech intelligibility, objective quality measures, ASR
The developmental effects of media ‐ ideal internalization and self ‐ objectification processes on adolescents ’ negative body ‐ feelings , dietary restraint , and binge eating

posited in objectification theory among media-ideal internalization, self-objectification, shame and anxiety surrounding the body and appearance, dietary restraint, and binge eating. Data collected from 685 adolescents aged between 14 and 15 at baseline (47 % males), who were interviewed and completed standardized measures annually over a 3-year period, were analyzed using a structural equation modeling approach. Results indicated that media-ideal internalization predicted later thinking and scrutinizing of one’s body from an external observer’s standpoint (or self-objectification), which then predicted later negative emotional experiences related to one’s body and appearance. In turn, these negative emotional experiences predicted subsequent dietary restraint and binge eating, and each of these core features of eating disorders influenced each other. Differences in the strength of these associations across gender were not observed, and all indirect effects were significant. The study provides valuable information about how the cultural values embodied by gendered beauty ideals negatively influence adolescents’ feelings, thoughts and behaviors regarding their own body, and on the complex processes involved in disordered eating. Practical implications are discussed.