Miracle-dz/UniFAR-FTUs huggingface dataset:
OPTICAL MATRIX - VECTOR MULTIPLICATION AND TWO-CHANNEL PROCESSING WITH PHOTODICHROIC CRYSTALS

This dissertation deals with two optical methods for data processing. The first method works with incoherent light. It is based on optical analog methods developed by Bromley in 197^ for performing the operations of correlation and convolution. This method yields the product of a two-dimensional matrix operator on a one-dimensional input column vector. The ele­ ments of the input column vector are represented by a time sequence of an intensity-modulated incoherent light beam. The two-dimensional matrix operator is represented by a transmission mask. Several optical transforms are performed by use of this method. The case of the discrete cosine transform is investigated experimentally to confirm the the­ oretical calculations. The second method works with coherent light. The processing is performed by spatial frequency filters. The approach parallels that of Marathay, who in 1969 laid the theoretical foundation for the realization of real bipolar and complex spatial filters for two-channel coherent optical processing using the polarization discrimination properties of Vectograph film. The technique of Marathay is an alter­ native to the Vander Lugt and Lohmann techniques of record­ ing complex spatial filters on conventional recording media
The Adherence of Home Pelvic Floor Muscles Training Using a Mobile Device Application for Women With Urinary Incontinence: A Randomized Controlled Trial

Supplemental digital content is available in the text. Objectives The objective of this study was to evaluate the use of a mobile device application (app) for the treatment of urinary incontinence through adherence to home pelvic floor muscle training (PFMT) and its impact on urinary symptoms. Methods This prospective randomized study included women with stress urinary incontinence. They were randomized into 2 groups: the app group, which used an app developed using the same visual component of electromyography as a guide for PFMT and followed exercises shown on the screen, and the control group, which received written instructions with the same protocol as the app group but without the dynamic sequence of PFMT images. Exercises were done twice a day. Reevaluation was repeated at 1, 2, and 3 months after the initial evaluation. Changes in urinary and vaginal symptoms were evaluated using questionnaires, and the Oxford Modified Scale was determined through digital palpation. Results Twenty-one women were included in the study (app group, n = 12; control group, n = 09). Adherence (number of repetitions) was higher in the app group at 2 and 3 months after PFMT (P < 0.001), but adherence decrease, especially in the control group, at 1, 2, and 3 months. Vaginal symptoms (P < 0.001), quality of life (P = 0.003), urinary symptoms (P < 0.001), and stress urinary symptoms (P < 0.001) showed improvement comparing baseline and during treatment, but there was no difference between the app and control groups (P values, 0.887, 0.817, 0.573, and 0.825, respectively). Conclusions Using the app increased adherence to PFMT in women with urinary incontinence symptoms and improved subjective perception.
The burden of at-home preparation of lyophilized parenteral medications: an analysis of contributing factors and implications for chronic disease patients and caregivers

ABSTRACT Background: In the acute care setting, parenteral medication errors are well-studied. However, there is comparatively little research on how these issues translate to patient- or caregiver-prepared medications in the home, particularly with reconstituted medications. Methods: This was an ethnographic study designed to identify issues associated with four reconstitution use scenarios. Preparation burden was determined by measuring the time and manipulations required to prepare reconstituted medications across three preparation phases (assembly, reconstitution, and transfer). Deviations from product instructions for use, sterility breaches, self-reported preparation complications, and supply storage conditions were also analyzed. Results: A total of 14 participants completed the study. Overall, preparation burden was markedly higher when purpose-built reconstitution devices were not available. The majority of participants reported experiencing at least one complication associated with their medication preparation process; the reconstitution phase was the most significant source of both instructions for use deviations and breaches in sterility. Participants reported that the volume and variety of medication preparation supplies were a significant source of burden. Conclusions: At-home preparation of reconstituted medications poses several challenges for patients and caregivers. As parenteral medications continue to shift towards self-administration, manufacturers should carefully consider the usability of such products and employ purpose-built reconstitution devices whenever possible.
Six months versus two years of oral anticoagulation after a first episode of unprovoked deep-vein thrombosis. The PADIS-DVT randomized clinical trial

The optimal duration of anticoagulation after a first episode of unprovoked deep-vein thrombosis is uncertain. We aimed to assess the benefits and risks of an additional 18 months of treatment with warfarin versus placebo, after an initial 6 months of anticoagulation for a first unprovoked proximal deep-vein thrombosis. We conducted a multicenter, randomized, double-blind, controlled trial comparing an additional 18 months of warfarin with placebo in patients with a unprovoked proximal deep-vein thrombosis initially treated for 6 months (treatment period: 18 months; follow up after treatment period: 24 months). The primary outcome was the composite of recurrent venous thromboembolism or major bleeding at 18 months. Secondary outcomes were the composite at 42 months, as well as each component of the composite, and death unrelated to pulmonary embolism or major bleeding, at 18 and 42 months. All outcomes were centrally adjudicated. A total of 104 patients, enrolled between July 2007 and October 2013 were analyzed on an intention-to-treat basis; no patient was lost to follow-up. During the 18-month treatment period, the primary outcome occurred in none of the 50 patients in the warfarin group and in 16 out of 54 patients (cumulative risk, 29.6%) in the placebo group (hazard ratio, 0.03; 95% confidence interval: 0.01 to 0.09; P<0.001). During the entire 42-month study period, the composite outcome occurred in 14 patients (cumulative risk, 36.8%) in the warfarin group and 17 patients (cumulative risk, 31.5%) in the placebo group (hazard ratio, 0.72; 95% confidence interval: 0.35-1.46). In conclusion, after a first unprovoked proximal deep-vein thrombosis initially treated for 6 months, an additional 18 months of warfarin therapy reduced the composite of recurrent venous thrombosis and major bleeding compared to placebo. However, this benefit was not maintained after stopping anticoagulation. Clinical registration: this trial was registered at www.clinicaltrials. gov as #NCT00740493.
Radiological and Clinical Outcome After Reversed L‐Shaped Osteotomy: A Large Retrospective Swiss Cohort Study

&NA; The objective was to report radiological and clinical outcomes after reversed L‐shaped osteotomy (ReveL) for hallux valgus (HV). A retrospective cohort study was performed between January 2004 and December 2013. The primary outcome was radiological recurrence of HV (HV angle [HVA] >15°). There were various exposure and secondary outcome variables. The results showed a median follow‐up of 12.0 months (N = 827). Radiological recurrence, limited patient satisfaction, complication, revision surgery, and elective hardware removal were found in 25.0%, 15.3%, 4.6%, 2.5%, and 26.7%. Median pre‐ to postoperative changes were highest for HVA (delta = –16.7°). Recurrence was more likely in cases with preoperative HVA ≥40° (adjusted odds ratio [ORadjusted]) 3.63, p < . 001). Revisions were more likely with concomitant diseases and bilateral surgery (ORadjusted 12.53, p = .010; ORadjusted 3.35, p = .030). Hardware removal was less likely in patients ≥50 years (ORadjusted 0.67, p = .014). In conclusion, ReveL was a good surgical option for HV because of the relatively low rates of unfavorable outcomes.
Biomarker combination is necessary for the assessment of Gaucher disease?

Biomarkers are useful tools to help in disease diagnosis and follow-up. According to the US Food & Drug Administration, biomarkers are defined as measurable elements that can be used as indicators in normal biological and pathological processes, or in response to an exposure or therapeutic interventions. Molecular, histologic, radiographic or physiological characteristics are some of those biomarkers (www.fda.gov). The term biomarker is currently being applied to molecular markers that define a specific biological status (1). Considering these factors, the “ideal” biomarker should fulfill susceptibility/risk, be reliable, and can be used for diagnosis, monitoring, prognosis, prediction and pharmacodynamic response.
Understanding the Impact and Misconceptions of Rural Plastic Surgery

Abstract In the United States, 54 million people live in a designated health service area with either no plastic surgeon or less than 1 plastic surgeon per 100,000 population. Previous studies demonstrate that patients in rural communities often have limitations with access to basic primary care services and subspecialty care services. Such limitations can have significant adverse impacts on health care and quality of life. Plastic and reconstructive surgeons offer unique advantages especially within rural settings given their broad scope of surgical skillsets. The purposes of this study are to illustrate the shortage of plastic and reconstructive surgeons within rural America catchment regions, identify and outline certain care offerings provided by these surgical specialists, and highlight the potential impact having such specialists directly involved in provision of care to patients within rural community settings. Our group will present data demonstrating misperceptions and an unawareness by hospital administrators on routine care services provided through plastic surgery practices. We will also report on selective surgical offerings of 2 rural-based plastic surgeons and outline certain financial and reimbursement findings from their practices, while also illustrating the impact of their practice on their patients and the health care systems they provide coverage.
Open Learning Environments and the Impact of a Pedagogical Agent

Research reveals that in highly structured learning environments pedagogical agents can act as tools to direct students' learning processes by providing content or problem solving guidance. It has not yet been addressed whether pedagogical agents have a similar impact in more open learning environments that aim at fostering students' acquisition of complex problem solving skills. To fill this gap, this study compares two experimental conditions to a control condition. In the first experimental condition, the pedagogical agent's interventions are adapted to students' activities (APA-group). In the second experimental group, the agent interferes on fixed time intervals (NPA-group). Students work on an environmental problem in an open learning environment. It was hypothesized that the two experimental groups would outperform the control group and, additionally, that the APA-group would outperform the NPA-group. Results show that the NPA-group outperforms the control group, and that the APA-group takes a middle position, not differing from either the NPA-group or the control-group. Consequently, the second hypothesis was not confirmed. An agent providing adapted advice did not result in better performance. The discussion provides some possible explanations for these results.
Effect of Descent Velocity upon Muscle Activation and Performance in Two-Legged Free Weight Back Squats

Background: The aim of this study was to investigate the effect of descent velocity during two-legged full back squats upon muscle activation and squat ascent performance. Methods: Eleven healthy resistance-training males (age: 24 ± 6 years, body mass: 89.5 ± 21.5 kg, height: 1.84 ± 0.10 m) performed 4-repetition maximum (4-RM) two-legged full squats with slow, normal, and fast descent phases. Kinematics and muscle activity of ten muscles divided into five regions were measured. Results: The main findings were that maximal and minimal velocity were lower and maximal velocity occurred later in the slow condition, while there was no difference in second peak velocity or ascent displacement when compared with the normal and fast conditions. Furthermore, no differences in muscle activation were found as an effect of the descent velocity. Conclusion: It was concluded that the slow descent velocity had a negative effect upon the ascent phase, because of the lower peak velocity and peak force increasing the chance of failure. The lower velocities were not caused by lower pre-activation of the muscles but were probably a result of potentiation and/or utilization of stored elastic energy and/or the stretch reflex.
Mass media reportage of Lassa fever in Nigeria: a viewpoint

In Nigeria, the mass media are used independently or complementarily in health promotion activities to achieve positive lifestyle changes. The mass media can play a positive role in combating the Lassa fever epidemic and its attendant fatality in Nigeria. The present review is necessitated by the widespread reportage and persistence of Lassa fever infection and fatality in Nigeria. From June to October 2018, the authors searched for relevant information in the grey literature, Scopus database, PubMed, Cochrane database, Google, and Nigerian newspapers and magazines, among other sources. Based on the reviewed literature, the authors argue that the mass media reportage of Lassa fever is limited in its content and undermined by poor network connection, the time of the day the broadcasts are made, and people’s indifference. These factors have posed a hindrance to health and environmental behaviours that would help to prevent Lassa fever and have resulted in cases of Lassa fever. It is recommended that media reporters intensify efforts at understanding the best time of the day to broadcast Lassa fever prevention information. The mass media should also make efforts toward providing accurate information regarding disease outbreak because this might help reduce panic and resistance to control and prevention measures.
Stress-Strain Response of Cylindrical Rubber Fender under Monotonic and Cyclic Compression

The study was devoted to the observation and modeling the mechanical behaviors of a hybrid SBR/NR (Styrene-Butadiene/Natural Rubber) hybrid vulcanized rubber fender under monotonic/cyclic compression. In experimental observations of the monotonic compression tests, it was found that lateral deformation occurred on the tested fender and was more significant with increasing the extent of the compressive strain. The relationship between the transmission stress Sc and the compressive strain ec was nonlinear and the absorbed strain-energy-density was increased monotonically with the increment of the compressive strain. Among all cyclic compression tests with strain controlled, the reductions in both the stress range and the absorbed strain-energy-density up to the ten-thousandth cycle were found and then both of the cyclic properties remain approximately constant in the following compression cycles. Two new properties, the softening factor and the energy reduction factor, were introduced to quantify the effect of the strain range on the extent of the reduction in stress range and that on the absorbed strain-energy-density, respectively. It was found that both of the calculated values of the new properties increase with the increment of strain range. In mathematical modeling of the relationship between the transmission stress and the compressive strain, a new approach based on energy-polynomial-function Es(ec) was presented and was successfully used to simulate the monotonic curve and the stable hysteresis loop curves of the tested rubber fender in compression. Essentially, the energy-polynomial-function Es(ec) was obtained by performing a polynomial regression on a large amount of (ec,Es) data. Moreover, the least-square approach was applied to determine the corresponding regression coefficients in Es(ec). Clearly, the stress-polynomial-function in modeling the Sc−ec curve could be obtained from the differentiation of the energy-polynomial-function with respect to the compressive strain. In addition, to provide an adequate estimation of the mechanical properties of the cylindrical rubber fender under compression, the named cyclic stress-strain curve and cyclic energy-strain curve were developed and also modeled in this study.
Suppression of Hepatic CYP3A4 Expression and Activity by 3-Methylcholanthrene in Humanized PXR-CAR-CYP3A4/3A7 Mice

Polycyclic aromatic hydrocarbons (PAHs) are environmental pollutants that activate the aryl hydrocarbon receptor, thereby triggering a range of biologic responses, exemplified by the induction of CYP1A1. PAHs can also regulate the expression of members of the CYP3A subfamily, with reports of mainly suppressive effects on mouse hepatic Cyp3a11 expression, but paradoxically both inductive and suppressive effects on human hepatic CYP3A4 expression. Understanding the regulation of CYP3A4 expression by PAHs is important because of the widespread exposure of humans to these chemicals and the central role of the CYP3A4 enzyme in the metabolism of clinically important drugs and endogenous substances. The present study used 3-methylcholanthrene (MC) as a model PAH to characterize the in vivo regulation of CYP3A4 expression and activity in humanized pregnane X receptor–constitutive androstane receptor-CYP3A4/3A7 mice. Adult mice were treated by intraperitoneal injection with MC (80 mg/kg), or corn oil vehicle, and euthanized 24 or 72 hours later. As a positive control response, pronounced induction of hepatic Cyp1a1 by MC was confirmed at both time points in males and females at the mRNA, protein, and catalytic activity levels. Basal hepatic CYP3A4 expression and activity were significantly higher in female versus male mice. MC treatment suppressed hepatic CYP3A4 in female mice at 72 hours postdosing at the mRNA, protein, and catalytic activity levels. A similar response was observed in male mice, although the suppression of CYP3A4 protein levels did not achieve statistical significance. This mouse model will facilitate further studies of the mechanisms and consequences of CYP3A4 suppression by PAHs.
NHLBI-Sponsored Randomized Trial of Postconditioning During Primary Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction

Rationale: Postconditioning at the time of primary percutaneous coronary intervention (PCI) for ST-segment–elevation myocardial infarction may reduce infarct size and improve myocardial salvage. However, clinical trials have shown inconsistent benefit. Objective: We performed the first National Heart, Lung, and Blood Institute–sponsored trial of postconditioning in the United States using strict enrollment criteria to optimize the early benefits of postconditioning and assess its long-term effects on left ventricular (LV) function. Methods and Results: We randomized 122 ST-segment–elevation myocardial infarction patients to postconditioning (4, 30 seconds PTCA [percutaneous transluminal coronary angioplasty] inflations/deflations)+PCI (n=65) versus routine PCI (n=57). All subjects had an occluded major epicardial artery (thrombolysis in myocardial infarction=0) with ischemic times between 1 and 6 hours with no evidence of preinfarction angina or collateral blood flow. Cardiac magnetic resonance imaging measured at 2 days post-PCI showed no difference between the postconditioning group and control in regards to infarct size (22.5±14.5 versus 24.0±18.5 g), myocardial salvage index (30.3±15.6% versus 31.5±23.6%), or mean LV ejection fraction. Magnetic resonance imaging at 12 months showed a significant recovery of LV ejection fraction in both groups (61.0±11.4% and 61.4±9.1%; P<0.01). Subjects randomized to postconditioning experienced more favorable remodeling over 1 year (LV end-diastolic volume =157±34 to 150±38 mL) compared with the control group (157±40 to 165±45 mL; P<0.03) and reduced microvascular obstruction (P=0.05) on baseline magnetic resonance imaging and significantly less adverse LV remodeling compared with control subjects with microvascular obstruction (P<0.05). No significant adverse events were associated with the postconditioning protocol and all patients but one (hemorrhagic stroke) survived through 1 year of follow-up. Conclusions: We found no early benefit of postconditioning on infarct size, myocardial salvage index, and LV function compared with routine PCI. However, postconditioning was associated with improved LV remodeling at 1 year of follow-up, especially in subjects with microvascular obstruction. Clinical Trial Registration: URL: http://www.clinicaltrials. gov. Unique identifier: NCT01324453.
Efficacy of iron isomaltoside among anemic females of Bundelkhand region: An interventional study

Introduction: More than a quarter of the world's population is anemic with about one half of the burden from iron deficiency. The prevention and treatment of iron deficiency is a major public health goal especially in women in low-income countries. Challenges in the treatment of iron deficiency include a selection of an iron replacement product that can be given as high-dose intravenous (IV) infusion in single visit with good safety profile. In this pilot study, a new IV therapeutic agent iron isomaltoside 1000 with above-desired properties was investigated to establish its efficacy in the treatment of iron deficiency anemia (IDA). Material and Methods: This 3 months' prospective interventional hospital-based study was conducted on 42 nonpregnant women with moderate-to-severe anemia attending obstetrics and Gynecology Department at Government Medical College Banda in Bundelkhand region. Pre- and post-hemoglobin (Hb) estimation after 3 weeks of a single shot of iron isomaltoside 1000 IV infusion was done. A rise in Hb of 2 g/dl or more at 21 days was considered a satisfactory response. SPSS software 17.0 version was used for data analysis. Results: Mean preinfusion Hb was found to be 7.139 g/dl and mean postinfusion Hb was found to be 10.088 g/dl. Thus, a rise of 2.949 g/dl in mean Hb after 3 weeks was recorded after a single infusion of iron isomaltoside among the anemic females. Conclusion: Iron isomaltoside has demonstrated robust efficacy in patients suffering from IDA due to different etiologies. The wide dosing range allows iron correction in a single visit with minimal risk of anaphylaxis and is thus cost-effective for health-care system.