Miracle-dz/UniFAR-FTUs huggingface dataset:
Worse disease-free, tumor-specific, and overall survival in surgically-resected lung adenocarcinoma patients with ALK rearrangement

Introduction This study determined the prevalence of anaplastic lymphoma kinase (ALK) rearrangement, and identified the associations of ALK rearrangement with clinicopathologic characteristics and treatment outcomes in patients with surgically-resected stage I-III lung adenocarcinoma. Methods A total of 534 surgically-resected lung adenocarcinoma patients were studied. The prevalence of ALK protein over-expression was determined by a fully-automated immunochemistry assay (with mouse monoclonal Ventana D5F3 antibody), and the associations of ALK rearrangement with clinicopathologic characteristics and treatment outcomes were analyzed. Results Forty-two (7.9%) of the 534 lung adenocarcinoma patients were ALK IHC-positive. ALK rearrangement was significantly associated with younger age (P = 0.011), high T-stage (P = 0.025), high pathologic stage (P = 0.002), solid predominant adenocarcinoma with mucin production (P = 0.006), invasive mucinous adenocarcinoma (P = 0.009), and receipt of adjuvant therapy after surgery (P = 0.036), but no significant associations were found between the ALK rearrangement and sex or smoking status. ALK IHC-positivity was significantly associated with a shorter disease-free survival, tumor-specific survival, and overall survival (P = 0.001, 0.026, and 0.007, respectively). Multivariate analysis showed that ALK IHC-positivity was an adverse prognostic factor for disease-free survival (HR, 1.80; 95% CI 1.18-2.77; P = 0.007), tumor-specific survival (HR, 2.59; 95% CI 1.35-4.97; P = 0.004), and overall survival (HR, 1.92; 95% CI 1.07-3.44; P = 0.030). Conclusion The clinical characteristics of patients with ALK-positive lung adenocarcinoma were similar to those of EGFR-mutated patients. ALK rearrangement was an adverse prognostic factor in surgically-resected lung adenocarcinoma patients.
Health-ATM: A Deep Architecture for Multifaceted Patient Health Record Representation and Risk Prediction

Leveraging massive electronic health records (EHR) brings tremendous promises to advance clinical and precision medicine informatics research. However, it is very challenging to directly work with multifaceted patient information encoded in their EHR data. Deriving effective representations of patient EHRs is a crucial step to bridge raw EHR information and the endpoint analytical tasks, such as risk prediction or disease subtyping. In this paper, we propose Health-ATM, a novel and integrated deep architecture to uncover patients’ comprehensive health information from their noisy, longitudinal, heterogeneous and irregular EHR data. Health-ATM extracts comprehensive multifaceted patient information patterns with attentive and time-aware mod-ulars (ATM) and a hybrid network structure composed of both Recurrent Neural Network (RNN) and Convolu-tional Neural Network (CNN). The learned features are ﬁnally fed into a prediction layer to conduct the risk prediction task. We evaluated the Health-ATM on both ar-tiﬁcial and real world EHR corpus and demonstrated its promising utility and eﬃcacy on representation learning and disease onset predictions.
WEAK AND STRONG CONVERGENCE THEOREMS FOR FAMILIES OF NONLINEAR AND NONSELF MAPPINGS IN HILBERT SPACES

In this paper, using a new class of nonlinear mappings called demimetric, we first prove a weak convergence theorem by the Mann type iteration for finding a common element of the set of common fixed points of an infinite family of these new demimetric mappings and the set of common solutions of variational inequality problems for an infinite family of inverse strongly monotone mappings in a Hilbert space. Furthermore, we prove a strong convergence theorem by the Halpern type iteration for the families in a Hilbert space. Using these results, we obtain new weak and strong convergence theorems in a Hilbert space.
Pathophysiology and treatment of achalasia in a muscle mechanical perspective

This review provides a biomechanical perspective on the pathophysiology and treatment of achalasia. The esophagus is efficient in transporting ingested material to the stomach in healthy subjects. A fine balance exists between the peristaltic forces generated in the esophageal body (which herein is defined as the preload) and the resistance in the outlet, the esophago‐gastric junction (which is defined as the afterload). Achalasia is a rare esophageal disease that progressively over many years challenges esophageal efficacy. Clinical features and current literature are interpreted using well‐known muscle mechanics models and terms from cardiac mechanophysiology. The preload, afterload, length–tension, and strain softening concepts in particular are useful for understanding the remodeling induced by achalasia. The concepts are also useful in understanding the treatment that aim to reduce the lower esophageal sphincter pressure that does not relax sufficiently in achalasia. These treatments cover endoscopic or laparoscopic myotomy, pneumatic balloon dilation, and Botox injections. In addition to the intended reduction of the afterload for aboral transport of ingested materials, the treatments tend to induce gastroesophageal reflux in some patients because they obliterate an important component in the reflux barrier.
Arterial stiffness and vascular complications in patients with type 1 diabetes: The Finnish Diabetic Nephropathy (FinnDiane) Study

Abstract Introduction/aims. While patients with type 1 diabetes (T1D) are known to suffer from early cardiovascular disease (CVD), we examined associations between arterial stiffness and diabetic complications in a large patient group with T1D. Methods. This study included 807 subjects (622 T1D and 185 healthy volunteers (age 40.6 ± 0.7 versus 41.6 ± 1.2 years; P = NS)). Arterial stiffness was measured by pulse wave analysis from each participant. Furthermore, information on diabetic retinopathy, nephropathy, and CVD was collected. The renal status was verified from at least two out of three urine collections. Results. Patients with T1D without signs of diabetic nephropathy had stiffer arteries measured as the augmentation index (AIx) than age-matched control subjects (17.3% ± 0.6% versus 10.0% ± 1.2%; P < 0.001). Moreover, AIx (OR 1.08; 95% CI 1.03–1.13; P = 0.002) was associated with diabetic laser-treated retinopathy in patients with normoalbuminuria in a multivariate logistic regression analysis. The same was true for AIx and diabetic nephropathy (1.04 (1.01–1.08); P = 0.004) as well as AIx and CVD (1.06 (1.00–1.12); P = 0.01) in patients with T1D. Conclusions. Arterial stiffness was associated with microvascular and macrovascular complications in patients with T1D.
DHTM: Durable Hardware Transactional Memory

The emergence of byte-addressable persistent (non-volatile) memory provides a low latency and high bandwidth path to durability. However, programmers need guarantees on what will remain in persistent memory in the event of a system crash. A widely accepted model for crash consistent programming is ACID transactions, in which updates within a transaction are made visible as well as durable in an atomic manner. However, existing software based proposals suffer from significant performance overheads. In this paper, we support both atomic visibility and durability in hardware. We propose DHTM (durable hardware transactional memory) that leverages a commercial HTM to provide atomic visibility and extends it with hardware support for redo logging to provide atomic durability. Furthermore, we leverage the same logging infrastructure to extend the supported transaction size (from being L1-limited to LLC-limited) with only minor changes to the coherence protocol. Our evaluation shows that DHTM outperforms the state-of-the-art by an average of 21% to 25% on TATP, TPC-C and a set of microbenchmarks. We believe DHTM is the first complete and practical hardware based solution for ACID transactions that has the potential to significantly ease the burden of crash consistent programming.
Identifying Safety Training Resource Needs in the Cattle Feeding Industry in the Midwestern United States

Cattle feedyards are a high-risk environment. They are characterized by high rates of occupational injuries and illnesses. As such, there is a clear need to address the health and safety of cattle feedyard workers. Therefore, the purpose of this cross-sectional study was to explore safety training practices and preferences in the cattle feeding industry. A survey of feedyard managers, feedyard safety trainers, and feedyard operators was conducted (n = 28). We found that only half of respondents had dedicated safety personnel; however, there was interest in a safety training program, conducted through short hands-on and in-person methods with materials available in English and Spanish. The majority of participants were also interested in a feedyard safety certification program. Participants reaffirmed the importance of partnering with industry and other stakeholders when conducting these types of programs. The results of this Phase 1-type translational research study will be used to guide the development of feedyard safety trainings and a corresponding recognition program for feedyards and feedyard workers as part of the “Improving Safety and Health of Cattle Feedyard Workers” project.
Welfare and punishment The relationship between welfare spending and imprisonment

ISSN 1746-6938 PAPER Introduction We present here a brief outline of findings from our research, which explores the relationship between welfare expenditure and levels of punishment. We begin by examining research on welfare spending and imprisonment rates across US states and replicate this work using data from 18 countries, including the United Kingdom. The results show that welfare provision relates significantly to penal policy and practice, as measured by the scale of imprisonment, and indicate that welfare cutbacks imply penal expansionism.
Advance Sales System with Price-Dependent Demand and an Appreciation Period under Trade Credit

With globalization, companies are facing fierce competition. Offering an appreciation period has become a commonly adopted method by retailers to sustain competitive advantage. During the appreciation period, customers can request to return products for any reason. In addition, retailers provide advance sales to attract additional customers. The supplier usually provides the retailer with a trade credit, which they can use as a type of price reduction to attract additional customers. Price is viewed as an important vehicle to sell products and enhance revenues. Therefore, in this article, we establish an inventory model with price-dependent demand for a retailer who simultaneously receives trade credit from its supplier, and offers advance sales and an appreciation period to its customers. We first establish a proper model and then provide an easy-to-use method to obtain an ordering policy for the retailer to achieve its maximum total profit. Finally, numerical examples are given to illustrate the solution procedure.
Evaluation of the impact of S-adenosylmethionine-dependent methyltransferase inhibitor, 3-deazaneplanocin A, on tissue injury and cognitive function in mice

Cancer patients display cognitive impairment due, at least partly, to the treatments. Additionally, chemotherapeutic treatments can lead to organ injury, limiting their use, and are likely to have negative impacts on patients’ quality of life. The aim of this study was to investigate the toxicity of 3-Deazaneplanocin A (DZNep) on several tissues and organs, as well as on cognitive functions. DZNep is an inhibitor of S-adenosylmethionine-dependent methyltransferase (in particular of the histone methyltransferase EZH2) which showed antitumoral functions in preclinical trials but whose effects on behavior and on organs (side effects) are not known. Chronic injections of DZNep were performed intraperitoneally in male NMRI mice (2 mg/kg; i.p.; three times per week) during 8 weeks. A follow-up of body weight was assessed during all experiments. Histological analysis were performed on several organs. EZH2 expression and H3K27me3 were assayed by western-blot. Several behavioral tests were performed during treatment and 2 weeks after. A particular focus was made on spontaneous locomotor activity, cognitive functions (spontaneous alternation and recognition memory), and anxiety- and depression-related behavior. Hematological modifications were also assessed. Chronic DZNep treatment transiently reduced animal growth. It had no effect on most organs but provoked a reversible splenomegaly, and persistent testis reduction and erythropoiesis. DZNep administration did not alter animal behavior. In conclusion, this study is encouraging for the use of DZNep for cancer treatment. Indeed, it has no effect on animal behavior, conferring an advantageous safety, and induces irreversible side effects limited on testis which are unfortunately found in most chemotherapy treatments.
Clapping in time parallels literacy and calls upon overlapping neural mechanisms in early readers

The auditory system is extremely precise in processing the temporal information of perceptual events and using these cues to coordinate action. Synchronizing movement to a steady beat relies on this bidirectional connection between sensory and motor systems, and activates many of the auditory and cognitive processes used when reading. Here, we use Interactive Metronome, a clinical intervention technology requiring an individual to clap her hands in time with a steady beat, to investigate whether the links between literacy and synchronization skills, previously established in older children, are also evident in children who are learning to read. We tested 64 typically developing children (ages 5–7 years) on their synchronization abilities, neurophysiological responses to speech in noise, and literacy skills. We found that children who have lower variability in synchronizing have higher phase consistency, higher stability, and more accurate envelope encoding—all neurophysiological response components linked to language skills. Moreover, performing the same task with visual feedback reveals links with literacy skills, notably processing speed, phonological processing, word reading, spelling, morphology, and syntax. These results suggest that rhythm skills and literacy call on overlapping neural mechanisms, supporting the idea that rhythm training may boost literacy in part by engaging sensory‐motor systems.
An Assessment Of Laboratory Experiments In Accounting

A reading of back issues of the major academic journals in accounting suggests an increasing number of laboratory experiments. Since 1970, the results of over 100 experiments have been published in Accounting, Organizations and Society, The Accounting Review, and the Journal of Accounting Research. These experiments have focused on the behavior of subjects in response to a wide variety of settings and stimuli. Our intent here is to provide an assessment of laboratory experiments in accounting. We do not intend to provide a review of these experiments, since several reviews of experimental research in accounting are available. Dyckman, Gibbins, and Swieringa [1978] review and evaluate experimental and survey research in financial accounting, Gibbins [1977] reviews behavioral research in auditing, and Ashton [1982], Libby [1981], and Libby and Lewis [1977; 1982] review human information processing research in accounting. Also, a review of the diverse accounting experiments would have to be very general. For example, Berelson used to summarize Berelson and Steiner [1964], which contained 1,045 established propositions about human behavior, with three propositions: (1) some do, some don't; (2) the differences aren't very great; and (3) it's more complicated than that. These propositions also may provide more than a casual summary of results from laboratory experiments in accounting.
Enabling Stroke Rehabilitation in Home and Community Settings: A Wearable Sensor-Based Approach for Upper-Limb Motor Training

High-dosage motor practice can significantly contribute to achieving functional recovery after a stroke. Performing rehabilitation exercises at home and using, or attempting to use, the stroke-affected upper limb during Activities of Daily Living (ADL) are effective ways to achieve high-dosage motor practice in stroke survivors. This paper presents a novel technological approach that enables 1) detecting goal-directed upper limb movements during the performance of ADL, so that timely feedback can be provided to encourage the use of the affected limb, and 2) assessing the quality of motor performance during in-home rehabilitation exercises so that appropriate feedback can be generated to promote high-quality exercise. The results herein presented show that it is possible to detect 1) goal-directed movements during the performance of ADL with a <inline-formula> <tex-math notation="LaTeX">$c$ </tex-math></inline-formula>-statistic of 87.0% and 2) poorly performed movements in selected rehabilitation exercises with an <inline-formula> <tex-math notation="LaTeX">$F$ </tex-math></inline-formula>-score of 84.3%, thus enabling the generation of appropriate feedback. In a survey to gather preliminary data concerning the clinical adequacy of the proposed approach, 91.7% of occupational therapists demonstrated willingness to use it in their practice, and 88.2% of stroke survivors indicated that they would use it if recommended by their therapist.
Online appendix for: Time-Dependent or State-Dependent Wage-Setting? Evidence from Periods of Macroeconomic Instability

This appendix contains four sections. Section A contains further details about our dataset and data treatment. Section B documents heterogeneity in wage changes across industries and occupations. In Section C, we estimate a selection model of wage changes, exploring both the factors influencing the probability of wage change and the size of change. Section D provides supplementary empirical results.
The splitting of solitary waves running over a shallower water

The Korteweg-de Vries type of equation (called KdV-top) for uni-directional waves over a slowly varying bottom that has been derived by Van Groesen and Pudjaprasetya [E. van Groesen, S.R. Pudjaprasetya, Uni-directional waves over slowly varying bottom. Part I. Derivation of a KdV-type of equation, Wave Motion 18 (1993) 345–370. ] is used to describe the splitting of solitary waves, running over shallower water, into two (or more) waves. Results of numerical computations with KdV-top are presented; qualitative and quantitative comparisons between the analytical and numerical results show a good agreement.c ©1999 Elsevier Science B.V. All rights reserved.
EPIDEMIOLOGY OF PARASITIC INFECTION IN MADRAS RED SHEEP IN TAMIL NAIDU

Helminth parasites of Madras Red sheep were studied during the period of January2008 to February2009. The fecal samples were collected from sheep and subjected to worms’ egg per gram of feces (EPG). A total of 95 sheep faces were examined of which 87(91.58%) were positive for one or more species of helminth worm egg parasites and the average epg in affected animals and the whole flocks depicted Table 1 and 2. Among them five species belonged to trematode namely Fasiola hepatica, Fasiola gigentica, Paramphistomum cervi, Cotylophoron cotylophorum and Gastrothylax crumenifer, two species of cestodes namely Moneiza expanda, Moniezia benedeni and five species belonged to nematodes namely Haemonhus contortus, Trichostrongylus species, Oesophagostomum columbianum, Strongyloides papillosus, and Trichuris ovis. Relatively, higher occurrence was recorded (94.29%) in winter (87.50%) in summer and rainy (86.11%) seasons. In relation to age and sex wise prevalence of helminth parasites in young (< 1 year) and in old (> 2 year) sheep was 100% and it was 100% in females and 80.71% in male respectively. The possible source of infection and mortality in sheep might be due to presence of small ponds, lakes and thick vegetation which is favourable for free living infective stage on pasture, on the other hand as meteorological conditions of a locality have profound effects of the parasite epizootiology was conductive for the optimum growth and proliferation of parasites in this thick vegetation. The result revealed no specific blood protozoan could be detected. In conclusion, egg counts in excess of 1000 are generally considered indicative of heavy infection. However, a low EPG is not necessarily indicative of very low infection, since one part of the worm population may just have started to reach patency, but may already cause disease and the worms egg parasites may affect development of host immunity.
Role of inhibitory control in modulating spread of focal ictal activity

Focal seizure propagation is classically thought to be spatially contiguous. However, propagation through the epileptic network – a collection of disparate epileptic nodes – has been theorized. Here, we used a multielectrode array, wide field calcium imaging, and two-photon calcium imaging to study focal seizure propagation pathways in an acute rodent neocortical 4-aminopyridine model. Although ictal neuronal bursts did not propagation beyond a 2-3 mm region, they were associated with hemisphere-wide LFP fluctuations and parvalbumin-positive interneuron activity outside the seizure focus. Globally compromising this inhibitory response using bicuculline surface application resulted in classical contiguous propagation; whereas, focal bicuculline microinjection resulted in epileptic network formation with two physically disparate foci. Our study suggests both classical and epileptic network propagation could arise from inhibition defects without pre-existing pathological connectivity changes, and that preferred propagation pathways may result from variations in cortical topology.
Endoscopic sleeve gastroplasty for obesity: A multicenter study of 248 patients with 24 months follow-up.

Endoscopic sleeve gastroplasty (ESG), a novel, incisionless, minimally invasive procedure, is developed as a non-surgical alternative for the management of obesity. It is a transoral gastroplasty procedure that utilizes a full-thickness endoscopic suturing system (OverStitch; Apollo Endosurgery) for the reduction of gastric volume by approximately 70%. In this procedure, sutures are placed in two rows along the greater curvature of the stomach, from the anterior wall to the greater curvature to the posterior wall, resulting in a gastric cavity that forms a tubular sleeve along the lesser curvature, with the closing of the greater curvature via plications from the gastroesophageal junction to the prepyloric antrum (1).
The role of perspective taking and emotions in punishing identified and unidentified wrongdoers

We present two studies examining the effect of identifiability on willingness to punish, emphasising that identifiability of the wrongdoer may increase or decrease willingness to punish depending on the punisher's perspective. When taking the wrongdoer's perspective, identifiability increases pity and decreases anger towards the wrongdoer, leading to a lighter punishment. On the other hand, when adopting the injured perspective, identifiability decreases pity and increases anger, resulting in a severe punishment. We show that while deliberation and rational factors affect the decision regardless of identification, the role of emotions in the decision is greater in the identified condition. Possible implications for public and educational policy are discussed.