Miracle-dz/UniFAR-FTUs huggingface dataset:
Software signature derivation from sequential digital forensic analysis

Author(s): Nelson, Alexander Joseph | Advisor(s): Long, Darrell Don Earl | Abstract: Hierarchical storage system namespaces are notorious for their immense size, which is a significant hindrance for any computer inspection. File systems for computers start with tens of thousands of files, and the Registries of Windows computers start with hundreds of thousands of cells. An analysis of a storage system, whether for digital forensics or locating old data, depends on being able to reduce the namespaces down to the features of interest. Typically, having such large volumes to analyze is seen as a challenge to identifying relevant content. However, if the origins of files can be identified---particularly dividing between software and human origins---large counts of files become a boon to profiling how a computer has been used. It becomes possible to identify software that has influenced the computer's state, which gives an important overview of storage system contents not available to date.In this work, I apply document search to observed changes in a class of forensic artifact, cell names of the Windows Registry, to identify effects of software on storage systems. Using the search model, a system's Registry becomes a query for matching software signatures. To derive signatures, file system differential analysis is extended from between two storage system states to many sequences of states. The workflow that creates these signatures is an example of analytics on data lineage, from branching data histories. The signatures independently indicate past presence or usage of software, based on consistent creation of measurably distinct artifacts. A signature search engine is demonstrated against a machine with a selected set of applications installed and executed. The optimal search engine according to that machine is then turned against a separate corpus of machines with a set of present applications identified by several non-Registry forensic artifact sources, including the file systems, memory, and network captures. The signature search engine corroborates those findings, using only the Windows Registry.
Implementing knowledge management in the Palestinian public sector institutions: empirical study on the presidency of the Palestinian government

This paper focuses on bridging the theoretical and empirical approaches of knowledge management (KM) key enablers in the Palestinian public sector, which are essential to facilitate and ensure a successful implementation of KM; these key enablers are: Organizational culture, leadership, personnel, information technology. For this purpose, a questionnaire was personally distributed to all (46) technical, administrative, and supervisory employees working at the Presidency of the Palestinian Government. Total of (44) fully answered questionnaires were received. The results showed a significant positive relationship between KM key enablers and the level of performance in the Palestinian Ministers’ Council by 0.829. It also indicated that 70% of the variation in the performance level has been significantly explained and influenced by KM key enablers. The recommendations proposed by this paper will provide a strategic direction for the Palestinian public administration to act more effectively with KM practices, and pay a focused attention to its key enablers.
Magnetic Resonance Imaging in Gynecological Oncology

Magnetic resonance imaging (MRI) has become an indispensable tool in the assessment of malignant disease. With increasingly sophisticated systems and technical advancements, MRI has continued to expand its role in providing crucial information regarding cancer diagnosis and management. In gynecological malignancies, this modality has assumed greater responsibility, particularly in the evaluation of cervical and endometrial cancers. In addition to conventional imaging, innovative techniques such as dynamic contrast-enhanced MRI and diffusion-weighted MRI show promise in offering early assessment of tumor response. This paper reviews the current role of MRI in gynecological cancers and highlights the potential of novel techniques in improving patient care.
Combination of chemotherapy with interleukin-2 and interferon alfa for the treatment of metastatic melanoma.

PURPOSE The primary objective of this clinical study was to assess the feasibility of administering recombinant interleukin-2 and recombinant interferon alfa-2a before and after combination cytotoxic chemotherapy. After encouraging initial responses, the study was expanded to further evaluate the therapeutic potential, clarify the toxicities of this regimen, and explore any associated immunologic changes. PATIENTS AND METHODS Eighty-four patients with metastatic melanoma, including patients with brain metastases, were treated on this 6-week protocol. Patients received combination cisplatin (25 mg/m2/d) and dacarbazine (220 mg/m2/d) on days 1 through 3 and 22 through 24 plus carmustine (150 mg/m2) on day 1. Interleukin 2 (13.5 million IU/m2/d) and interferon alfa (6 MU/m2/d) were administered on days 4 through 8 and 17 through 21. RESULTS Among 83 patients assessable for response, 12 complete and 34 partial responses were documented (55% response rate). The median time to disease progression was 7 months, the median survival from study entry was 12.2 months, and the median survival from diagnosis of metastatic disease was 15.5 months. Although patients were hospitalized to receive treatment, intensive care unit support generally was not needed. Dose-limiting toxicities were related to elevations in serum bilirubin and serum creatinine levels. No patient developed a grade 4 clinical toxicity. Treatment produced a skin depigmentation, which was associated with prolonged survival. CONCLUSION A plateau in both the survival and time to progression curves beyond 2 years (15% of the patients) and a greater than 10% disease-free survival beyond 4 years indicate that there may be a long-term benefit for some patients. The limited toxicity of this regimen should permit its use in most oncology settings. A randomized trial of chemoimmunotherapy versus chemotherapy should be performed to establish the value of chemoimmunotherapy for melanoma.
FOXL2 Is a Sensitive and Specific Marker for Sex Cord-Stromal Tumors of the Ovary

Sex cord-stromal tumors (SCSTs) of the ovary are relatively uncommon tumors. Diagnosis of SCST rests primarily on the histomorphology of these tumors, and tumors with an atypical or unconventional appearance can pose diagnostic challenges. Previously, we had identified FOXL2 (402C→G) mutation as being characteristic of adult granulosa cell tumors (aGCTs). However, molecular screening for this mutation is not always possible and adds time and cost to the diagnostic process. In this study, we investigated the potential diagnostic use of immunostaining for FOXL2 on formalin-fixed paraffin-embedded tissue sections. Using a commercially available polyclonal antiserum against FOXL2 protein, immunoexpression of FOXL2 was tested in 501 ovarian tumor samples, including 119 SCSTs, using whole tissue sections and tissue microarrays. Staining was correlated with FOXL2 mutation status. In addition, we compared FOXL2 immunoexpression with that of &agr;-inhibin and calretinin, the 2 traditional immunomarkers of SCST, in a subset of 89 SCSTs. FOXL2 immunostaining was present in 95 of 119 (80%) SCSTs, including >95% of aGCTs, juvenile granulosa cell tumors, fibromas, and sclerosing stromal tumors. Only 50% of Sertoli-Leydig cell tumors (N=40) expressed FOXL2. One of 11 steroid cell tumors and 3 of 3 female adnexal tumors of probable Wolffian origin showed FOXL2 immunoreactivity, whereas all other non-SCSTs tested (N=368) were negative for FOXL2 expression. Thus, the sensitivity and specificity of FOXL2 immunoreactivity for SCST are 80% and 99%, respectively. The FOXL2 (402C→G) mutation was confirmed to be both a sensitive and relatively specific indicator of aGCT. Forty-five of 119 SCSTs were mutation positive. These cases were 39 of 42 (93%) aGCTs, 3 of 40 Sertoli-Leydig cell tumors, 2 of 5 thecomas, and 1 of 4 (25%) SCSTs of unclassified type. SCSTs harboring a FOXL2 mutation consistently immunoexpressed FOXL2 (44 of 45, 98%), but FOXL2 immunostaining was also seen in many SCSTs that lacked a mutation (49 of 73, 67%). FOXL2 immunostaining showed higher sensitivity for the diagnosis of SCST, compared with &agr;-inhibin and calretinin, and FOXL2 staining was typically more intense in positive cases compared with either &agr;-inhibin or calretinin. In the SCSTs that were negative for FOXL2 expression, &agr;-inhibin and/or calretinin immunostaining yielded positive results. In conclusion, FOXL2 is a relatively sensitive and highly specific marker for SCST. FOXL2 staining is present in almost all SCSTs with a FOXL2 mutation, and also in a majority of SCSTs without a mutation. FOXL2, together with &agr;-inhibin and calretinin, forms an immunomarker panel that will result in positive staining with 1 or more markers in essentially all cases of SCST.
Effect of Treatment with Stimulant Medication on Nonverbal Executive Function and Visuomotor Speed in Children with Attention Deficit/Hyperactivity Disorder (ADHD)

This study used a novel hidden maze learning test to examine the nature and magnitude of impairment on separable aspects of executive function in 36 children with ADHD. A within-subject analysis of children with ADHD was also conducted to assess cognitive effects of open-label stimulant treatment. Compared to 31 age-matched controls, unmedicated children with ADHD were slower and made significantly more errors that were indicative of relative impairment in prepotent response inhibition and ability to “maintain set” while using simple rules to complete the task. Open-label administration of stimulant medication led to faster and more efficient performance, with children with ADHD making fewer perseverative and rule-break errors than when off medication. This instrument might be useful in monitoring treatment response in specific aspects of executive function and in assisting with dose-titration decisions.
Genetic risk assessment and prevention: the role of genetic testing panels in breast cancer

Multigene panel tests are being increasingly used for the genetic assessment of women with an apparent predisposition to breast cancer. Here, we review all studies reporting results from individuals who have undergone multigene panel testing for hereditary breast cancer. Across all gene panel studies, the prevalence of pathogenic mutations was highest in BRCA1 (5.3%) and BRCA2 (3.6%) and was lowest in PTEN (0.1%), CDH1 (0.1%) and STK11 (0.01%). After BRCA1/2, the prevalence of pathogenic mutations was highest in CHEK2 (1.3%), PALB2 (0.9%) and ATM (0.8%). The prevalence of variants of unknown significance was highest in ATM (9.6%). Based on the prevalence and penetrance of pathogenic mutations and the prevalence of variants of unknown significance, it is our interpretation that BRCA1, BRCA2, PALB2 and CHEK2 are the best candidates for inclusion in a clinical multigene breast cancer panel.
Control of mitochondrial ATP synthesis in the heart.

over 90% of its ATP is made by mitochondrial oxidative phosphorylation. Thus, to a first approximation, we can consider the heart as a system in which ATP is made by the mitochondrial ATP synthase (F1Fo ATPase) and consumed by contraction. The validity of this model is attested by the correlation between heart work rate and the rate of oxidative phosphorylation (as measured by oxygen uptake) [2]. A number of recent reviews have dealt with the control of oxidative phosphorylation in the heart [1,3-9]. In general, however, they have concentrated on the means employed by the cell to modulate the mitochondrial electron transfer chain; the ATP synthase was considered as essentially responding passively to changes in these other events. It is the aim of this Review to redress the balance and focus attention on the ATP synthase within heart mitochondria, and on its regulation.
Inhibition of the Soluble Form of Testis Adenylate Cyclase by Catechol Estrogens and Other Catechols

Abstract The soluble form of rat germ cell adenylate cyclase was inhibited by compounds with a catechol moiety. Among the naturally occurring catechols tested, catechol estrogens were the most potent inhibitors. Catechol estrogens at 2–6 μM inhibited enzyme activity by 50% and almost completely at 30–100 μM concentration. The inhibitory activity of catechol estrogens depends on the catechol moiety of the molecule. Catechol per se also inhibited the activity of this enzyme, 50% inhibition being achieved at about 11 μM. The two hydroxyls of the catechol moiety are essential for the inhibitory interaction with the enzyme. Thus, aromatic compounds containing only one hydroxyl group in the benzene ring, such as tyrosine, phenylephrine, estradiol, and 6α-hydroxyestradiol were either completely inactive or had marginal inhibitory activity at concentrations up to 0.3–1 mM. Moreover, methylation of the hydroxyl groups of the catechol moiety of the catechol estrogens as in 2-methoxyestradiol 3-methyl ether rendered the catechol estrogens inactive. The inhibitory potency of these compounds varied greatly depending on the structure associated with the catechol ring. Thus, compounds in which catechol is associated with an aliphatic side chain, such as dopamine, l-dopa, norepinephrine, and isoproterenol, were about 11- to 34-fold less potent than catechol. On the other hand, compounds in which catechol is associated either with a hydroaromatic ring system, as in apomorphine, or with an alicyclic ring system, as in catechol estrogens, were about 2- to 5-fold more potent than catechol. The inhibitory effect of dopamine, apomorphine, and catechol estrogens was not affected by specific D-1 or D-2 antagonist, indicating that they do not act via receptors for dopamine.
Nailfold Capillaroscopy in Hypothyroidism and Hyperthyroidism: Blood Flow Velocity During Rest and Postocclusive Reactive Hyperemia

Direct intravital microscopic examinations of nailfold capillaries were made in three groups of subjects: 15 healthy volunteers (C) and 11 patients, six with hypothyroidism (h) and five with hyperthyroidism (H). The groups h and H were examined twice, before the onset of treatment and when they returned to euthyroidism. Capillary blood flow velocity (CBFV) was measured during rest and after release of 60-second arterial occlusion. To assess autoregulatory capacity the authors determined peak CBFV postoc clusion and time to reach it in single capillaries. In patients with hypothyroidism, before the onset of the treatment, the mean resting and the mean peak CBFV were significantly lower (resting CBFV—group C: 0.93 ±0.11 mm/s (mean ±SE); group h: 0.33 ±0.09 mm/s; and mean peak CBFV—group C: 1.49 ±0.14 mm/s; group h: 0.79 ±0.19 mm/s). The time to reach mean peak CBFV postocclusion was significantly prolonged (group C: 8.9 ±0.65 s and group h: 19.2 ±2.0 s) compared with the group of healthy volunteers. When these patients achieved euthyroidism, all the studied parameters returned to control levels. In patients with hyperthyroidism only minor changes in CBFV could be detected. In patients with hypothyroidism, the skin microvascular autoregulatory mech anisms are disturbed. The impairments of the reactive hyperemia response could be corre lated with the control of the disease (thyroid state).
(6-Methoxy-2-oxo-2H-chromen-4-yl)methyl piperidine-1-carbodithioate

In the title compound, C17H19NO3S2, the maximum deviation of atoms in the 2H-chromene ring system is 0.0097 (14) Å and the piperidine ring adopts a chair conformation. The dihedral angle between the 2H-chromene ring and the piperidine ring (all atoms) is 87.59 (8)°. In the crystal, inversion dimers linked by pairs of C—H⋯O interactions generate R 2 2(22) loops. Further C—H⋯O hydrogen bonds link the dimers into [110] chains and weak aromatic π–π stacking [shortest centroid–centroid distance = 3.824 (8) Å] is also observed.
Corporate Tax Avoidance in SME: The Effect of Listing

Accounting Standards for Small- and Medium-sized Entities (AS-SMEs) is legislated for small- and medium- sized entities that are not obligated to conduct external audit, to provide better understanding for the accountant and useful information for the users. In the case of small- and medium-sized entities (SMEs), unlike conglomerates, they are qualified to appliance of tax cut provisions and tax subsidy from SMEs aid policy; so they are conjectured to have less motive to avoid tax due to low tax burden when compared to non-SMEs. When going public as a mean to finance, unlisted small- and medium-sized firms are obligated to report financial information to external stakeholders. At the same time, external supervision and check will become inevitable in operating business for these firms. On the other hand, there exists possibility for the SMEs with relatively weak financial structure compared to those unlisted, to avoid tax through IPO process. Therefore, this paper attempts to investigate whether listed SMEs have more tendency to avoid tax than unlisted SMEs. We also empirically tests whether is differing of in between will make a contribution in providing policy implications by inspecting whether SMEs have motive to avoid tax by comparing tax avoidance in SMEs and non-SMEs.
Exercise in hot and cold environments: differential effects on leukocyte number and NK cell activity.

INTRODUCTION Exercise and environmental temperature have been reported to affect the immune system, but few studies have examined the combined effects of very hot or cold temperatures during exercise in the same group of subjects. Therefore, the purpose was to examine the immune responses following exercise combined with exposure to hot and cold environments. METHODS There were 10 men who completed 2 60-min cycle ergometry (60% VO2peak) trials: hot (HT: 38 degrees C, 45% RH) and cold (CD: 8 degrees C, 50% RH). Rectal core temperatures (Tc), average skin temperatures (Tsk), and HR were recorded every 15 min of exercise. Venous blood was collected before (PRE), immediately after (POST), 2 h after (2 h), and 24 h after exercise (24 h). Physiologic strain index (PSI) was calculated. Total and differential leukocytes were determined by manual counting (adjusted for plasma volume shifts). Natural killer cell activity (NKCA) was determined by a whole blood 51Cr-release assay. RESULTS Tsk, Tc, and PSI were significantly lower in the CD than HT trial (p < 0.05). Total leukocyte count was greater POST (40%) and 2 h (74%) than PRE and 24 h in both conditions (p < 0.05). Neutrophil count was greater POST (49%) and 2 h (132%) than PRE and 24 h in both conditions (p < 0.05). Lymphocyte count was greater POST (24%) in HT than CD (p < 0.05). NKCA was greater POST (38%) than PRE, 2 h, and 24 h in both conditions (p < 0.05). HT caused significant increases for Tc and Tsk above those observed for CD (p < 0.05). PSI was greater in HT (9.92 +/- 0.93) than CD (4.24 +/- 0.56) (p < 0.05). DISCUSSION Exercise in HT produced more physiological stress than CD; however, this difference was not manifested in the immune system response. Heat and cold stress in combination with exercise produce similar disturbances in immunity during recovery from exercise.
Rehabilitation of the pitching shoulder

Shoulder pain is a common complaint among baseball pitchers. Frequently, the nature of shoulder pathology can be traced to lack of flexibility and muscular imbal ance. This paper describes: (1) the normal biomechanics of a properly functioning shoulder during a baseball pitch, (2) pathomechanics of shoulder problems, (3) flexibility requirements of the throwing shoulder, and (4) the muscular balance necessary for an effective throwing shoulder. Appropriate examination procedures are de scribed along with remedial exercises which ensure normal glenohumeral motion and integrated muscle action.
PENGARUH KEPUTUSAN INVESTASI, PENDANAAN, DAN KEBIJAKAN DIVIDEN TERHADAP NILAI PERUSAHAAN

One of the primary objectives of the company is to optimize the firm value. This research is meant to examine the influence of investment decision, funding decision, and the dividend policy to the Firm Value.The samples are 38 consumer goods companies which are listed in Indonesia Stock Exchange (IDX) during the 2010-2014 periods which is suitable with the determined criteria and 12 companies have been obtained as samples. This research has been done by using purposive sampling method. The data analysis has been applied in this research is done by using multiple linear regressions with the application instrument of SPSS (Statistical Product and Service Solutions). The result of the research shows that investment decision has significant influence to the firm value, funding decision does not have any significant influence to the firm value, and dividend policy has significant influence to the Firm Value. The value of R square is 0,333 which shows that all of independent variables which are investment decision, funding decision, and dividend policy can explain the dependent variable i.e. firm value is 33,3% and the remaining is 66,7% which is influenced by other factors which are not included in this model. Keywords: Investment Decision, Funding Decision, Dividend Policy, Firm Value.
CT scan findings in chronic thromboembolic pulmonary hypertension: predictors of hemodynamic improvement after pulmonary thromboendarterectomy.

STUDY OBJECTIVES The aim was to correlate CT scan findings with hemodynamic measurements in patients who had undergone pulmonary thromboendarterectomy (PTE) and to evaluate whether CT scan findings can help to predict surgical outcome. PATIENTS AND METHOD Sixty patients who underwent PTE and preoperative helical CT scanning were included. Preoperative and postoperative hemodynamics were correlated with preoperative CT imaging features. RESULTS The diameter of the main pulmonary artery (PA) and the ratio of the PA and the diameter of the ascending aorta correlated with preoperative mean pulmonary artery pressure (PAP) [r = 0.42; p < 0.001; and r = 0.48; p < 0.0001, respectively]. There was a significant correlation of subpleural densities with preoperative pulmonary vascular resistance (PVR) [r = 0.44; p < 0.001] and of the number of abnormal perfused lobes with preoperative PAP (r = 0.66; p < 0.0001) and PVR (r = 0.76; p < 0.0001). Postoperative PVR correlated negatively with the presence and extent of central thrombi (r = -0.36; p = 0.007) and dilated bronchial arteries (p = 0.03) seen on preoperative CT scans. Sixty percent of patients (3 of 5 patients) without visible central thromboembolic material on CT scans had an inadequate hemodynamic improvement in contrast to 4% of patients (2 of 51 patients) with central thrombi (p = 0.003). Preoperative PVR (r = 0.31; p = 0.018) and the extent of abnormal lung perfusion (r = 0.37; p = 0.007) and of subpleural densities (r = 0.32; p = 0.017) were positively correlated with postoperative PVR. CONCLUSIONS In patients with thromboembolic pulmonary hypertension, CT scan findings can help to predict hemodynamic improvement after PTE. The absence of central thrombi is a significant risk factor for inadequate hemodynamic improvement.