Miracle-dz/UniFAR-FTUs huggingface dataset:
Contributory Factors to Postoperative Spinal Fusion Complications for Children With Myelomeningocele

Study Design. This is a retrospective review of all children with myelomeningocele (MMC) who were undergoing surgery for scoliosis at our institution. Objective. Our aim was to investigate possible correlations between poor nutritional indexes and/or positive urinary cultures before surgery to perioperative infection risk. Summary of Background Data. Patients who have scoliosis secondary to MMC have been shown to have a high rate of infectious complications. Many children with MMC have been found to have asymptomatic urinary tact infections due to their neurogenic bladder. There is little literature on risk factors for and ways to prevent postoperative infections for these patients. Methods. We reviewed a comprehensive database for the outcome for spinal fusion surgeries of 59 patients with MMC treated at our institution over the past 45 years. Perioperative infections were correlated to preoperative nutritional status (measured by patient hematocrit [Hct]) and presence of active infection using Fisher Exact Probability Test. Results. A total of 84 different spinal fusion operations for 59 patients were recorded. Patients presenting with poor preoperative nutrition (Hct ≤33) and positive preoperative urinary cultures demonstrated the highest risk for perioperative wound infection (P = 0.001). Patients with preoperative poor nutrition without a positive urinary culture as well as those with adequate nutritional status but a preoperative positive urinary culture showed an increased risk of wound infection respectively (P = 0.03) and (P = 0.002). Conclusion. Positive urine cultures obtained before spinal surgery for children with MMC significantly increased the risk for perioperative wound (P = 0.002). Urinary tract infections can be easily detected and treated. We believe urinary culture, protein deficiencies, or Hct ≤33, should be treated and corrected before surgery.
Development of the Italian Version of the Tampa Scale of Kinesiophobia (TSK-I): Cross-Cultural Adaptation, Factor Analysis, Reliability, and Validity

Study Design. Evaluation of the psychometric properties of a translated and culturally adapted questionnaire. Objective. Translating, culturally adapting, and validating the Italian version of the Tampa Scale of Kinesiophobia (TSK-I) to allow its use for Italian-speaking patients with low back pain. Summary of Background Data. Increasing attention is being given to standardized outcome measures as a means of improving interventions for low back pain. A translated form of the TSK in patients with low back pain has never been validated in the Italian population. Methods. The development of the TSK-I questionnaire involved its translation and back-translation, a final review by an expert committee, and testing of the prefinal version to establish its correspondence to the original English version. Psychometric testing included factor analysis, reliability by internal consistency (Cronbach's alpha) and test-retest repeatability (Intraclass Coefficient Correlation), discriminant validity (Pearson correlation) by comparing TSK-I to a visual analogue scale, the Roland Morris Disability Questionnaire, Beck's Depression Inventory and Anxiety Inventory. Results. It took the authors 5 months to achieve a shared version of the TSK-I, which proved to be satisfactorily acceptable when administered to 178 subjects. Factor analysis indicated a 2-factor 13-item solution (38% of explained variance). The questionnaire showed acceptable internal consistency (&agr; = 0.772) and high test-retest reliability (ICC = 0.956). Discriminant validity showed moderate to low correlations with visual analogue scale (r = 0.345), the Roland Morris Disability (r = 0.337), and Beck's Depression Inventory and Anxiety Inventory (r = 0.258 and r = 283). The subscales were also psychometrically analyzed. Conclusion. The TSK was successfully translated into Italian, showing a good factorial structure and psychometric properties, and replicating the results of existing English versions of the questionnaire. Its use is recommended for research purposes.
Reliability of peak running speeds obtained from different incremental treadmill protocols

Abstract This study compared the values and reliability of peak running speeds from incremental treadmill protocols with different speed increments. Thirty-one men, recreational, endurance-trained runners performed, in an alternate order, three continuous tests with different speed increments (0.5, 1 and 2 km · h−1). The tests were repeated using the same order. Peak speed was identified as (1) the greatest speed that could be maintained for a complete minute (Vpeak-60s), (2) the speed of the last complete stage (Vpeak-C) and (3) the speed of the last complete stage added to the product of the speed increment and the completed fraction of the incomplete stage (Vpeak-P). The Vpeak-P was the most reliable, independent of the incremental test protocol (1.5% ≤ CV ≤ 1.8%), and differently from Vpeak-C (1.8% ≤ CV ≤ 2.6%) and Vpeak-60s (1.6% ≤ CV ≤ 3.8%), the Vpeak-P was only slightly influenced by the incremental test protocol. The results suggest that Vpeak-P should be used to assess aerobic capability and monitor training effects and that other determinations of peak speed should be avoided.
Developmental profile of GABAA‐mediated synaptic transmission in pyramidal cells of the somatosensory cortex

Inhibitory synaptic transmission mediated by γ‐aminobutyric acid (GABA)A receptors is involved in regulation of experience‐dependent cortical plasticity. However, little information is available on their presynaptic and postsynaptic developmental profiles. The present study aims to investigate the developmental changes of miniature and unitary inhibitory postsynaptic currents (mIPSCs and uIPSCs) in mouse barrel cortex. mIPSCs recorded from supragranular pyramidal neurons showed a gradual increase in frequency during postnatal days 6–15 (PD6–15) followed by a marked increase at PD16–20, and mIPSCs frequency reached a plateau at about PD21–30. The amplitude of mIPSCs showed a transient decrease at PD10–12 followed by an increase during PD13–30, and reached a plateau at about PD30. Their decay time constant progressively decreased during the first 30 days postnatally, and reached a steady level at about PD30. Paired recordings from interneurons and synaptically coupled target pyramidal cells revealed that uIPSC amplitude increased with age up to PD30. In contrast, failure rate and coefficient of variation decreased during PD7–15 and showed little change at a later stage. Short‐term depression induced by presynaptic stimulation at 33 Hz progressively decreased during PD6–20, and was stabilized at about PD21–30. Quantal analysis revealed that the number of release sites increased with age up to PD30, while the release probability increased during PD6–12 and then reached a plateau level. These results suggest that the number of release sites and release probability of GABA and GABAA‐mediated IPSC kinetics show distinct developmental profiles, which could play roles in regulating the onset and offset of critical periods for experience‐dependent cortical plasticity.
The WldS gene delays axonal but not somatic degeneration in a rat glaucoma model

Glaucoma is a leading cause of blindness caused by progressive degeneration of retinal ganglion cells (RGCs) and their axons. The pathogenesis of glaucoma remains incompletely understood, but optic nerve (ON) axonal injury appears to be an important trigger of RGC axonal and cell body degeneration. Rat models are widely used in glaucoma research to explore pathogenic mechanisms and to test novel neuroprotective approaches. Here we investigated the mechanism of axon loss in glaucoma, studying axon degeneration in slow Wallerian degeneration (WldS) rats after increasing intraocular pressure. WldS delays degeneration of experimentally transected axons for several weeks, so it can provide genetic evidence for Wallerian‐like degeneration in disease. As apoptosis is unaffected, WldS also provides information on whether cell death results from axon degeneration or arises independently, an important question yet to be resolved in glaucoma. Having confirmed expression of WldS protein, we found that WldS delayed ON axonal degeneration in experimental rat glaucoma for at least 2 weeks, especially in proximal ON where wild‐type axons are most severely affected. The duration of axonal protection is similar to that after ON transection and crush, suggesting that axonal degeneration in glaucoma follows a Wallerian‐like mechanism. Axonal degeneration must be prevented for RGCs to remain functional, so pharmacologically mimicking and enhancing the protective mechanism of WldS could offer an important route towards therapy. However, WldS did not protect RGC bodies in glaucoma or after ON lesion, suggesting that combination treatments protecting both axons and cell bodies offer the best therapeutic prospects.
Concordance for Curve Type in Familial Idiopathic Scoliosis: A Survey of One Hundred Families

Study Design. Prospective comparative study on 100 patients with positive family history for idiopathic scoliosis. Objective. To evaluate the concordance rate for curve pattern and side in family members with idiopathic scoliosis. Summary of Background Data. The pathogenesis of idiopathic scoliosis has been the subject of extensive research. It is termed multifactorial with a genetic component. Similar curve shape has been reported in twins with idiopathic scoliosis. Methods. We included prospectively 100 patients with idiopathic scoliosis when a relative of them was also affected with idiopathic scoliosis, and spine radiographs were available for both. Concordance for curve pattern by Lenke classification and side between family members was analyzed. Results. Familial concordance rate for curve pattern and side was 66% (95% confidence interval, 57-75), whereas the expected random concordance rate was 26% (95% confidence interval, 17-34). The affected relative was in 27 cases a sibling, in 32 cases a parent, in 1 case an uncle, in 2 cases a cousin, in 2 cases a half sister, in 2 cases a grandmother. Concordance rate was 65% (27/42) in siblings' pairs and 67% (32/48) in parents/child's pairs. Conclusion. We report a high concordance rate for curve pattern and side between relatives with idiopathic scoliosis. Curve shape is likely to be genetically determined in familial scoliosis. It seems important that curve type is documented and considered in future genetic studies.
Neural basis of music imagery and the effect of musical expertise

Although the influence of long‐term musical training on the processing of heard music has been the subject of many studies, the neural basis of music imagery and the effect of musical expertise remain insufficiently understood. By means of magnetoencephalography (MEG) we compared musicians and nonmusicians in a musical imagery task with familiar melodies. Subjects listened to the beginnings of the melodies, continued them in their imagination and then heard a tone which was either a correct or an incorrect further continuation of the melody. Only in musicians was the imagery of these melodies strong enough to elicit an early preattentive brain response to unexpected incorrect continuations of the imagined melodies; this response, the imagery mismatch negativity (iMMN), peaked ∼175 ms after tone onset and was right‐lateralized. In contrast to previous studies the iMMN was not based on a heard but on a purely imagined memory trace. Our results suggest that in trained musicians imagery and perception rely on similar neuronal correlates, and that the musicians’ intense musical training has modified this network to achieve a superior ability for imagery and preattentive processing of music.
Functional characterization of GABAergic pallidopallidal and striatopallidal synapses in the rat globus pallidus in vitro

As a central integrator of basal ganglia function, the external segment of the globus pallidus (GP) plays a critical role in the control of voluntary movement. Driven by intrinsic mechanisms and excitatory glutamatergic inputs from the subthalamic nucleus, GP neurons receive GABAergic inhibitory input from the striatum (Str–GP) and from local collaterals of neighbouring pallidal neurons (GP–GP). Here we provide electrophysiological evidence for functional differences between these two inhibitory inputs. The basic synaptic characteristics of GP–GP and Str–GP GABAergic synapses were studied using whole‐cell recordings with paired‐pulse and train stimulation protocols and variance–mean (VM) analysis. We found (i) IPSC kinetics are consistent with local collaterals innervating the soma and proximal dendrites of GP neurons whereas striatal inputs innervate more distal regions. (ii) Compared to GP–GP synapses Str–GP synapses have a greater paired‐pulse ratio, indicative of a lower probability of release. This was confirmed using VM analysis. (iii) In response to 20 and 50 Hz train stimulation, GP–GP synapses are weakly facilitatory in 1 mm external calcium and depressant in 2.4 mm calcium. This is in contrast to Str–GP synapses which display facilitation under both conditions. This is the first quantitative study comparing the properties of GP–GP and Str–GP synapses. The results are consistent with the differential location of these inhibitory synapses and subtle differences in their release probability which underpin stable GP–GP responses and robust short‐term facilitation of Str–GP responses. These fundamental differences may provide the physiological basis for functional specialization.
Injury prevention in male veteran football players – a randomised controlled trial using “FIFA 11+”

Abstract The warm-up programme “FIFA 11+” has been shown to reduce football injuries in different populations, but so far veteran players have not been investigated. Due to differences in age, skill level and gender, a simple transfer of these results to veteran football is not recommended. The purpose of this study was to investigate the preventive effects of the “FIFA 11+” in veteran football players. Twenty veteran football teams were recruited for a prospective 9-month (1 season) cluster-randomised trial. The intervention group (INT, n = 146; 45 ± 8 years) performed the “FIFA 11+” at the beginning of each training session, while the control group (CON, n = 119; 43 ± 6 years) followed its regular training routine. Player exposure hours and injuries were recorded according to an international consensus statement. No significant difference was found between INT and CON in overall injury incidence (incidence rate ratio [IRR]: 0.91 [0.64–1.48]; P = 0.89). Only severe injuries reached statistical significance with higher incidence in CON (IRR: 0.46 [0.21–0.97], P = 0.04). Regular conduction (i.e. once a week) of the “FIFA 11+” did not prevent injuries in veteran footballers under real training and competition circumstances. The lack of preventive effects is likely due to the too low overall frequency of training sessions.
Predictors of outcome in palliative colonic stent placement for malignant obstruction

Emergency surgery for large bowel obstruction carries significant morbidity and mortality. After initially promising results, concerns have been raised over complication rates for self‐expandable metal stents (SEMS) in both the palliative and bridge‐to‐surgery settings. This article documents the technique used at the authors' institution, and reports on success and complication rates, as well as identifying predictors of endoscopic reintervention or surgical treatment.
Effects of isometric quadriceps strength training at different muscle lengths on dynamic torque production

Abstract This study aims to (1) determine whether isometric training at a short vs. long quadriceps muscle length affects concentric torque production; (2) examine the relationship between muscle hypertrophy and concentric torque; and (3) determine whether changes in fascicle length are associated with changes in concentric torque. Sixteen men performed isometric training at a short (SL, n = 8) or a long muscle length (LL, n = 8). Changes in maximal concentric torque were measured at 30, 60, 90, 120, 180, 240 and 300 rad · s−1. The relationships between the changes in concentric torque, cross-sectional area, volume and fascicle length were tested. Concentric torque increased significantly after training only in LL and at angular velocities of 30 and 120 rad · s−1 by 12–13% (P < 0.05). Muscle size increased in LL only, the changes were correlated (r = 0.73–0.93, P < 0.05) with the changes in concentric torque. Vastus lateralis (VL) fascicle length increased in both groups (5.4 ± 4.9%, P = 0.001) but the change was not correlated with changes in concentric torque in either group. Isometric training-induced increases in muscle size and concentric torque were best elicited by training at long muscle lengths. These results highlight a clear muscle length dependence of isometric training on dynamic torque production.
Impact of limited hamstring flexibility on vertical jump, kicking speed, sprint, and agility in young football players

Abstract This study aims to analyse the impact of limited hamstring flexibility (HF) on specific football skills, such as sprinting and jumping ability, agility, and kicking speed in young football players. Forty-three male football players (aged 14–18) from a semi-professional football academy participated voluntarily in this study. Data about anthropometric measurements, HF (unilateral passive straight-leg raise test: PSLR), vertical jumping ability (countermovement jump: CMJ), sprinting ability (5, 10, 20 m: S5 m, S10 m, S20 m), agility (Balsom agility test: BAT), and kicking speed in terms of ball speed (dominant and non-dominant leg: KSdom and KSnon-dom) were collected. Cluster analysis grouped according to HF, dividing participants into a flexible group (FG, n = 24) and a non-flexible group (NFG, n = 19) in relation to performances on the PSLR test. Despite finding no significant differences between groups in body composition and age, the FG performed better in terms of sprint scores (S5 m: 6.12%, S10 m: 4.09%, S20 m: 3.29%), BAT score (4.11%), CMJ score (10.49%), and scores for KSdom (6.86%) and KSnon-dom (8%) than the NFG. The results suggest that HF is a key factor for performing football-specific skills, such as sprinting, jumping, agility, and kicking in young football players. These results support the rationale that muscle flexibility must be specifically trained in football players beginning at early ages.
Circadian rhythms of PERIOD1 expression in the dorsomedial hypothalamic nucleus in the absence of entrained food‐anticipatory activity rhythms in rats

When food availability is restricted to a single time of day, circadian rhythms of behavior and physiology in rodents shift to anticipate the predictable time of food arrival. It has been hypothesized that certain food‐anticipatory rhythms are linked to the induction and entrainment of rhythms in clock gene expression in the dorsomedial hypothalamic nucleus (DMH), a putative food‐entrained circadian oscillator. To study this concept further, we made food availability unpredictable by presenting the meal at a random time each day (variable restricted feeding, VRF), either during the day, night or throughout the 24‐h cycle. Wheel running activity and the expression of the clock protein, Period1 (PER1), in the DMH and the suprachiasmatic nucleus (SCN) were assessed. Rats exhibited increased levels of activity during the portion of the day when food was randomly presented but, as expected, failed to entrain anticipatory wheel running activity to a single time of day. PER1 expression in the SCN was unchanged by VRF schedules. In the DMH, PER1 expression became rhythmic, peaking at opposite times of day in rats fed only during the day or during the night. In rats fed randomly throughout the entire 24‐h cycle, PER1 expression in the DMH remained arrhythmic, but was elevated. These results demonstrate that VRF schedules confined to the day or night can induce circadian rhythms of clock gene expression in the DMH. Such feeding schedules cannot entrain behavioral rhythms, thereby showing that food‐entrainment of behavior and circadian rhythms of clock gene expression in the DMH are dissociable.
A coach’s political use of video-based feedback: a case study in elite-level academy soccer

Abstract This paper examines the video-based pedagogical practices of Terry (pseudonym), a head coach of a professional junior academy squad. Data were collected through 6 in-depth, semi-structured interviews and 10 field observations of Terry’s video-based coaching in situ. Three embracing categories were generated from the data. These demonstrated that Terry’s video-based coaching was far from apolitical. Rather, Terry strategically used performance analysis technologies to help fulfil various objectives and outcomes that he understood to be expected of him within the club environment. Kelchtermans’ micropolitical perspective, Callero’s work addressing role and Groom et al.’s grounded theory were primarily utilised to make sense of Terry’s perceptions and actions. The findings point to the value of developing contextually grounded understandings of coaches’ uses of video-based performance analysis technology. Doing so could better prepare coaches for this aspect of their coaching practice.
Facilitation of corticospinal excitability in the tibialis anterior muscle during robot‐assisted passive stepping in humans

Although phasic modulation of the corticospinal tract excitability to the lower limb muscles has been observed during normal walking, it is unclear to what extent afferent information induced by walking is related to the modulation. The purpose of this study was to test the corticospinal excitability to the lower limb muscles by using transcranial magnetic stimulation (TMS) and transcranial electrical stimulation of the motor cortex while 13 healthy subjects passively stepped in a robotic driven‐gait orthosis. Specifically, to investigate the effect of load‐related afferent inputs on the corticospinal excitability during passive stepping, motor evoked potentials (MEPs) in response to the stimulation were compared between two passive stepping conditions: 40% body weight unloading on a treadmill (ground stepping) and 100% body weight unloading in the air (air stepping). In the rectus femoris, biceps femoris and tibialis anterior (TA) muscles, electromyographic activity was not observed throughout the step cycle in either stepping condition. However, the TMS‐evoked MEPs of the TA muscle at the early‐ and late‐swing phases as well as at the early‐stance phase during ground stepping were significantly larger than those observed during air stepping. The modulation pattern of the transcranial electrical stimulation‐evoked MEPs was similar to that of the TMS‐evoked MEPs. These results suggest that corticospinal excitability to the TA is facilitated by load‐related afferent inputs. Thus, these results might be consistent with the notion that load‐related afferent inputs play a significant role during locomotor training for gait disorders.