Miracle-dz/UniFAR-FTUs huggingface dataset:
The Life Paths and Lived Experiences of Adults Who Have Experienced Parental Alienation: A Retrospective Study

This qualitative study concerns the life paths and lived experiences of 6 adults who have been alienated from a parent in the past. The results suggest several hypotheses concerning the factors that might place children at risk of being alienated from a parent. The presence of postseparation conflict and, in some cases, domestic violence, as well as the triangulation of the child appear to be elements that favor the emergence of parental alienation. Moreover, this study supports a multifactorial explanation of parental alienation. In the scope of lived experience, respondents associated alienation with difficulties at school, internal and external behavior problems, and a search for identity after reaching adulthood. Finally, overcoming the state of alienation involves issues surrounding the establishment of boundaries with the alienating parent and the rebuilding of a relationship with the alienated parent.
IMPROVED BOUNDS ON BELL NUMBERS AND ON MOMENTS OF SUMS OF RANDOM VARIABLES

We provide bounds for moments of sums of sequences of independent random variables. Concentrating on uniformly bounded nonnegative random variables, we are able to improve upon previous results due to Johnson et al. [10] and Latała [12]. Our basic results provide bounds involving Stirling numbers of the second kind and Bell numbers. By deriving novel effective bounds on Bell numbers and the related Bell function, we are able to translate our moment bounds to explicit ones, which are tighter than previous bounds. The study was motivated by a problem in operation research, in which it was required to estimate the Lp-moments of sums of uniformly bounded non-negative random variables (representing the processing times of jobs that were assigned to some machine) in terms of the expectation of their sum. 2000 AMS Mathematics Subject Classification: Primary: 60E15; Secondary: 05A18, 11B73, 26D15.
Exploring the factors that enhance student–content interaction in a technology-mediated learning environment

Abstract The authors discuss the results of a study that was conducted on the factors that enhance effective interaction between students and learning contents in a technology-mediated learning environment in a higher education setting. The results revealed that effective student–content interaction is strongly enhanced by expansive learning through its five key elements; epistemic relation, contradictions, digital learning content, conglomeration of views and cognitive transformation. The intervening effect of network relations and mediating technology was also highlighted therefore, revealing the positive impact of both factors in enhancing effective student-content interaction. The empirical methods employed by the authors were focus group interview (n = 12) and questionnaire (n = 500) among students in a university. While Structural equation modelling was used to analyse the quantitative data, the focus group interviews were analysed using categories, themes and concepts. The authors present the findings and implications of the study by way of theory, practice and further research in the study.
Lamin B1 regulates somatic mutation and progression of B cell malignancies

Somatic hypermutation (SHM) is a pivotal process in adaptive immunity that occurs in the germinal centre and allows B cells to change their primary DNA sequence and diversify their antigen receptors. Here, we report that genome binding of Lamin B1, a component of the nuclear envelope involved in epigenetic chromatin regulation, is reduced during B cell activation and formation of lymphoid germinal centres. ChIP-Seq analysis showed that kappa and heavy variable immunoglobulin domains were released from the Lamin B1 suppressive environment when SHM was induced in B cells. RNAi-mediated reduction of Lamin B1 resulted in spontaneous SHM as well as kappa-light chain aberrant surface expression. Finally, Lamin B1 expression level correlated with progression-free and overall survival in chronic lymphocytic leukaemia, and was strongly involved in the transformation of follicular lymphoma. In summary, here we report that Lamin B1 is a negative epigenetic regulator of SHM in normal B-cells and a "mutational gatekeeper", suppressing the aberrant mutations that drive lymphoid malignancy. © 2017 Macmillan Publishers Limited. All rights reserved.
Dwarfs Cooler than “M”: The Definition of Spectral Type “L” Using Discoveries from the 2-Micron All-Sky Survey (2MASS)

Before the 2-Micron All-Sky Survey (2MASS) began, only six objects were known with spectral types later than M9.5 V. In the first 371 deg2 of actual 2MASS survey data, we have identified another 20 such objects spectroscopically confirmed using the Low Resolution Imaging Spectrograph (LRIS) at the W. M. Keck Observatory. Because the TiO and VO bands, which dominate the far-optical portions of late-M spectra, disappear in these cooler dwarfs, we define a new spectral class "L" in which metallic oxides are replaced by metallic hydrides and neutral alkali metals as the major spectroscopic signatures. We establish classification indices and type all 25 L dwarfs. The 26th "post-M9.5" object—Gl 229B—is the prototype of a methane-dominated spectral class, which we propose as class "T. " At least five of the 20 2MASS L dwarfs show the 6708 Å lithium doublet at low resolution, the strongest having an equivalent width of 18.5 Å. For objects this cool, the presence of lithium proves that they are substellar. Two other 2MASS objects appear to have lithium lines at the limit of our detectability, which if verified means that at least one-third of our L dwarfs are bona fide brown dwarfs. All of the 2MASS brown dwarfs discovered so far have J-Ks > 1.30. We have not yet, despite deliberately searching for them, found any brown dwarfs with colors resembling Gl 229B (J-Ks ≈ -0.1).
Lymphocytes Redirectedbya PSMA CD 3 Bispecific Single-ChainDiabody

BACKGROUND. For redirecting T-lymphocytes to induce prostate cancer cell lysis, we constructed a novel bispecific single-chain (bsc) diabody directed to the prostate specific membrane antigen (PSMA) and the T-cell receptor (TCR)-associated CD3 molecule on T-cells. METHODS. The PSMA CD3 bsc diabody was generated from an anti-CD3 single chain Fv fragment (scFv) and the anti-PSMA scFv D7. It was expressed in E. coli and purified from the periplasmic extract and culture supernatant by immobilized metal affinity chromatography (IMAC). The binding properties were tested on PSMA-expressing prostate cancer cells and PSMA-negative cell lines as well as on Jurkat cells by flow cytometry. For in vitro functional analysis, a cell viability test (WST-1) was used and activation of T-cells was determined by measuring the surface marker expression of CD25 and CD69. For in vivo evaluation, the diabody was administered in combination with human peripheral blood lymphocytes (Ly) in a C4-2 xenograft-SCID mouse model. RESULTS. Specific binding of the PSMA CD3 bsc diabody both to CD3-positive Jurkat cells and PSMA-expressing C4-2 cells was shown by flow cytometry. In vitro, the PSMA CD3 bsc diabody proved to be a potent agent for retargeting CD4þ and CD8þ human lymphocytes to lyse C4-2 prostate cancer cells. Treatment of SCID mice bearing C4-2 tumor xenografts with the diabody and human lymphocytes efficiently inhibited tumor growth. CONCLUSIONS. The PSMA CD3 bsc diabody bears a high potential for the immunotherapy of prostate cancer. Prostate 71: 588–596, 2011. # 2010 Wiley-Liss, Inc.
On behalf of the ELPAT psychosocial care for living donors and recipients working group

This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/tri.13041 This article is protected by copyright. All rights reserved. DR. EMMA KAY MASSEY (Orcid ID : 0000-0002-9017-1924) MISS HANNAH MAPLE (Orcid ID : 0000-0002-1330-0366)
ADHD in a Brazilian Sample of Adult Patients Lack of Association Between a 3 ' UTR VNTR Polymorphism of Dopamine Transporter Gene ( SLC 6 A 3 ) and

Objective: To investigate a possible association between a 3’UTR VNTR polymorphism of the dopamine transporter gene (SLC6A3) and ADHD in a Brazilian sample of adult patients. Method: Study Case-control with 102 ADHD adult outpatients (DSM-IV criteria) and 479 healthy controls. The primers’ sequence used were: 3’UTR-Forward: 5’ TGT GGT GAT GGG AAC GGC CTG AG 3’ and 3’UTR-Reverse: 5’ CTT CCT GGA GGT CAC GGC TCA AGG 3’. Alleles of the 3’UTR were coded according to their number of repeats: 6repeat 320 bp (allele 6), 8repeat 400 bp (allele 8), 9repeat 440 bp (allele 9), 10repeat 480 bp (allele 10), and 11repeat 520 bp (allele 11). Results: There were no allelic (c2 = 2.67, 5df, p = .75) and genotypic (c2 = 7.20, 1df, p = .61) association between adult ADHD and VNTR 3’UTR polymorphism of SLC6A3. Conclusion: Our findings do not support SLC6A3 as marker genetic susceptibility factor in adult ADHD. More comprehensive polymorphism coverage within the SLC6A3 region should be conducted in larger samples, including comparisons in clinical subgroups, and in samples with different ethnic backgrounds. (J. of Att. Dis. 2011; 15(4) 305-309)
Experimental Heat Transfer 1 NON-UNIFORM ONSET OF NUCLEATE FLOW BOILING OF 1 R-134 A INSIDE A GLASS MINICHANNEL

8 Even if far from being completely characterized, convective boiling inside miniand micro9 channels is likely to be one of the most relevant process for enhancing the cooling capability 10 of modern heat transfer devices. Since, due to the process miniaturization, many novel 11 devices are very small, fully developed flows are difficult to achieve, and therefore the 12 knowledge of the onset nucleate boiling (ONB) position is even more critical for cooling 13 design. However visualization of the ONB phenomena is not common in the literature, since 14 usually the heaters are made in opaque metals and therefore they are not allowing a complete 15 imagining. The present work consists in an experimental investigation of the incipient boiling 16 of R134a inside a circular glass mini-channel mounted horizontally and equipped with a series 17 of transparent Indium Tin Oxide (ITO) heaters. The effects of the heat flux input levels and 18 the refrigerant mass fluxes on the ONB process and on the saturated boiling heat transfer rate 19 are quantitatively explored. The flow pattern visualizations, carried on by means of a high20 speed camera, show that the nucleation process is oddly non-uniform: the first vapor bubbles 21 are always generated on the upper side of the tube and lead to a first wall temperature drop. A 22 further increase in the heat flux values results in an increased wall superheat until bubbles 23 nucleation originates also on the lower side of the tube causing a second wall temperature 24 drop. Finally, at higher heat input levels, the boiling process becomes uniformly distributed 25 on the inner tube surface. This phenomenon occurred also after a 180° rotation of the glass 26 1 Corresponding author
Basophils and the Th 2 environment in a spontaneous model of murine lupus

Systemic lupus erythematosus is a complex autoimmune disease of multifactorial origins. All compartments of the immune system appear to be affected, at least in some way, and to contribute to disease pathogenesis. Because of an escape from negative selection autoreactive T and B cells accumulate in SLE patients leading to the production of autoantibodies mainly raised against nuclear components and their subsequent deposition into target organs. We recently showed that basophils, in an IgE and IL-4 dependent manner, contribute to SLE pathogenesis by amplifying autoantibody production. Here, we summarize what we have learned about the deleterious role of basophils in lupus both in a mouse model and in SLE patients. We discuss which possible pathways could be involved in basophil activation and recruitment to secondary lymphoid organs during SLE, and how basophils may amplify autoantibody production.
The Fear Avoidance Model seeks a better understanding of the role of fear in explaining pain experience ( Crombez

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Efficient implementation of power-law attenuation of elastic waves in time-domain numerical simulations

Numerical simulation of wave propagation in the time domain is easily parallelizable on high performance computing systems due to the spatially local nature of the governing equations. The disadvantage of working in the time domain arises when lossy media must be modeled which generally gives rise to convolution-type loss terms in the governing time-domain equations. Computation of these convolutions usually requires the storage of several solution fields at thousands of previous time steps. This requirement can be memory prohibitive in three-dimensions. In this talk we present a recursive convolution approach to computing lossy (power-law) elastic wave propagation that is an extension of the one-way, one-dimensional acoustic wave equation work done by Liebler (M. Liebler et al., J. Acoust. Soc. Am., 116, 2004) in order to handle multiple dimensions and shear waves. Convolutions are computed recursively by first using a least-squares technique to fit the kernel of the convolution with a series of decaying.
Molecular phylogenetics of Chaetodon and the Chaetodontidae (Teleostei: Perciformes) with reference to morphology

Butterflyfish are colourful, pan-tropical coastal fish that are important and distinctive members of coral reef communities. A successful systematic scheme and a robust phylogeny is considered essential in understanding further their biogeography and ecology, although recent cladistic treatments of butterflyfish phylogeny, based on soft tissue and bone morphology and coded at the generic and subgeneric levels, differ in character coding and subsequently tree topology. This study provides an independent test of the morphologically based hypotheses, using molecular systematic data from two partial mitochondrial gene fragments, cytochrome b (cytb) and small subunit rRNA (rrnS), for 52 ingroup chaetodontids and seven pomacanthids used to root the molecular trees. Individual gene trees were largely compatible and a combined molecular phylogeny, inferred from Bayesian analysis, was used to test alternative hypotheses suggested by morphological analyses. The tree was also used to map the latest morphological matrix in order to evaluate potential synapomorphies for various nodes defining butterflyfish interrelationships. A clade comprised of Chelmon and Coradion was sister group to other chaetodontids. Heniochus and Hemitaurichthys were each resolved as monophyletic groups, and as sister taxa Of the taxa sampled, Prognothodes was resolved as the sister genus to Chaeotodon. Of the ten Chaetodon subgenera sampled, all were monophyletic but their interrelationships differed significantly from that inferred from morphological characters. Lepidochaetodon was the most basal subgenus followed by Exornator and the remaining subgenera. Molecular data support the sister group relationship between Corallochaetodon and Citharoedus suggested by morphology, but major differences occur among the remaining more derived taxa. Chaetodon trifascialis and C. oligacanthus were resolved as sister taxa adding weight to the inclusion of the latter in C. Megaprotodon. Of those pairs of taxa known to hybridize and sampled with molecular data, all were closely related phylogenetically, except those hybrids known to occur in the Rabdophorus subgenus. Two base changes separated C. pelewensis from C.
A Systematic measure of perceptual relatedness in false memories

Previous memory research has exploited the perceptual similarities between lures and targets in order to evoke false memories. Nevertheless, while some studies have attempted to use lures that are objectively more similar than others, no study has systematically controlled for perceptual overlap between target and lure items and its role in accounting for false alarm rates or the neural processes underlying such perceptual false memories. The current study looked to fill this gap in the literature by using a face-morphing program to systematically control for the amount of perceptual overlap between lures and targets. Our results converge with previous studies in finding a pattern of differences between true and false memories. Most importantly, expanding upon this work, parametric analyses showed false memory activity increases with respect to the similarity between lures and targets within bilateral middle temporal gyri and right medial prefrontal cortex (mPFC). Moreover, this pattern of activation was unique to false memories and could not be accounted for by relatedness alone. Connectivity analyses further find that activity in the mPFC and left middle temporal gyrus co-vary, suggestive of gist-based monitoring within the context of false memories. Interestingly, neither the MTL nor the fusiform face area exhibited modulation as a function of target-lure relatedness. Overall, these results provide insight into the processes underlying false memories and further enhance our understanding of the role perceptual similarity plays in supporting false memories.
Infrared Absorption from Charge Density Waves in Magnetic Manganites

The infrared absorption of charge density waves coupled to a magnetic background is first observed in two manganites ${\mathrm{La}}_{1\ensuremath{-}x}{\mathrm{Ca}}_{x}{\mathrm{MnO}}_{3}$ with $x\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}0.5$ and $x\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}0.67$. In both cases a BCS-like gap $2\ensuremath{\Delta}(T)$, which for $x\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}0.5$ follows the hysteretic ferromagnetic-antiferromagnetic transition, fully opens at a finite ${T}_{0}l{T}_{N}$, with $2\ensuremath{\Delta}({T}_{0})/{k}_{B}{T}_{c}\ensuremath{\simeq}5$. These results may also explain the unusual coexistence of charge ordering and ferromagnetism in ${\mathrm{La}}_{0.5}{\mathrm{Ca}}_{0.5}{\mathrm{MnO}}_{3}$.
Growth and length–weight relationships of Pseudorasbora parva (Temminck & Schlegel, 1846) in Hirfanlı Dam Lake: Comparison with traditional and artificial neural networks approaches

The present study was carried out to assess the population structure and growth with length weight relations, von Bertalanffy equations and artificial neural networks (ANNs) of topmouth gudgeon, between May 2015 and May 2016, in Hirfanli Dam Lake. The age of topmouth gudgeon caught from Hirfanli Dam Lake ranged between 1 to 5 years. The von Bertalanffy growth function growth coefficient k was 0.5 and asymptotic length L∞ was 91.3 mm fork length (FL). The weight-length relationship is given by the regression equation W = 0.01275334 × L3.0005 for all individual. Growth equations in length (mm) and weight (g) are: Lt = 91.3 [1–e–0.380 (t + 0.5)] and Wt = 10.36 [1–e–0.380 (t + 0.5)]3.0005 for all individual. Minimum and maximum size was 27 and 92 mm FL for all individuals. Here, we examine the growth properties (length and weight) of topmouth gudgeon by modern (artificial neural networks) and traditional approaches (Length weight Relations and von Bertalanffy growth model) in Hirfanli Dam Lake. This study presents the first LWR, von Bertalanffy and ANNs references for this species in Hirfanli Dam Lake.
PGC 1-alpha over-expression prevents metabolic alterations and soleus muscle atrophy in hindlimb unloaded mice Running title : PGC 1-α over-expression prevents soleus muscle atrophy during disuse

Prolonged skeletal muscle inactivity causes muscle fiber atrophy. Redox imbalance has been considered one of the major triggers of skeletal muscle disuse atrophy, but it is still debated whether redox imbalance is actually the major cause or simply a consequence of muscle disuse. Here we hypothesized that a metabolic stress mediated by PGC-1α down-regulation plays a major role in disuse atrophy. First we studied the adaptations of soleus to mice hindlimb unloading (HU) in the early phase of disuse (3 and 7 days HU) with and without antioxidant treatment (trolox). HU caused reduction of cross sectional area, redox status alteration (NRF2, SOD1 and catalase up-regulation), and induction of the ubiquitin proteasome system (MuRF-1 and atrogin-1 mRNA up-regulation) and autophagy (Beclin1 and p62 mRNA up-regulation). Trolox completely prevented the induction of NRF2, SOD1 and catalase mRNAs, but not atrophy and catabolic systems induction in unloaded muscles, suggesting that oxidative stress is not a major cause of disuse atrophy. HU mice showed a marked alteration of oxidative metabolism. PGC-1α and mitochondrial complexes were down-regulated and DRP1 was up-regulated. To define the link between mitochondrial dysfunction and disuse muscle atrophy we unloaded mice overexpressing PGC-1α. ) at NERL Consortia on August 17, 2014 jp.physoc. org Downloaded from J Physiol ( This article is protected by copyright. All rights reserved. 3 Transgenic PGC-1α animals did not show metabolic alteration during unloading preserving muscle size through the reduction of autophagy and proteasome degradation. Our results indicate that mitochondrial dysfunction plays a major role in disuse atrophy and that compounds inducing PGC-1α expression could be useful to treat/prevent muscle atrophy. Abbreviations: CuZnSOD1, superoxide dismutase1; DRPI, dynamin-related protein 1; 4EBP1, Eukaryotic translation initiation factor 4E-binding protein 1; MuRF-1, Musclespecific Ring Finger protein-1; NRF2, Nuclear factor , erythroid derived 2, like 2 (Nfe2l2); PGC-1α, peroxisome proliferative activated receptor-γ coactivator 1α
Prevalence of malaria and geohelminth co-infection among antenatal women at the Federal Medical Centre and Specialist Hospital, Yola, Adamawa Sate, Nigeria

Malaria and geohelminths are known to be associated with pregnancy within all age groups. The objective of this study was to determine the prevalence of malaria and geohelminths co-infection among pregnant women. The study was conducted on 252 pregnant women who came for antenatal visits at Federal Medical Center and Specialist Hospital within Yola metropolis from July to November 2015. Socio-demographic information of the pregnant women was collected. Capillary blood from finger prick was used for malaria screening by microscopy. Geohelminths were determined by stool examination using wet mount and formal ether concentration techniques. Malaria, geohelminths and co-infecion had 20.2%, 21.4%, and 6.3% prevalence, respectively. Those within 20-24 and 25-29year age group had high rate of coinfection of 2.4% each. The results show no association between age and coinfection p <0.05. Malaria was significant in this study at p< 0.05. The result show relatively low rate of coinfection of malaria and geohelminths prevalence. Keywords: Prevalence, Malaria, Geohelminths, Coinfection, Hospital, Yola