Miracle-dz/UniFAR-FTUs huggingface dataset:
Gonadotropin-releasing hormone analog repairs reduced endometrial cell apoptosis in endometriosis in vitro.

OBJECTIVE Impaired sensitivity of endometrial tissue to spontaneous apoptosis in women with endometriosis contributes to the abnormal implantation and growth of endometrium at ectopic sites. Our purpose was to examine the effect of gonadotropin-releasing hormone analog, widely used in the treatment of endometriosis, on the reduced rate of endometrial apoptosis in endometriosis. STUDY DESIGN Paired ectopic and eutopic endometrial tissue specimens were obtained from 13 patients with endometriosis, and control samples were taken from 8 patients with uterine myoma. Apoptotic cell death was assessed biochemically and morphologically with an enzyme-linked immunoassay and Hoechst No. 33342 staining of deoxyribonucleic acid fragment, respectively. RESULTS Spontaneous apoptosis was significantly lower in ectopic and eutopic endometrial tissue from patients with endometriosis (0.22 +/- 0.082 in absorbance) than in endometrial tissue from control subjects (0.52 +/- 0.483)(P < 0.001). Incubation with a gonadotropin-releasing hormone analog (1 micromol/L) increased the apoptotic rate of endometrial cells from patients with endometriosis to 0.56 +/- 0.501 (P <.001). The effect of this gonadotropin-releasing hormone revealed a dose dependency; a half-maximal effect occurred with 10 nmol/L; however, the control endometrium was not affected. CONCLUSION Exposure to gonadotropin-releasing hormone results in changes of the sensitivity of endometriotic endometrium to spontaneous apoptosis; these changes in sensitivity may, in turn, release endometrial cells from resistance to apoptosis and result in reduced survival and growth. This phenomenon could, at least in part, account for the therapeutic action of gonadotropin-releasing hormone analog on endometriosis.
The Cid1 family of non‐canonical poly(A) polymerases

Polyadenylation is an essential processing step for most eukaryotic mRNAs. In the nucleus, poly(A) polymerase adds poly(A) tails to mRNA 3′ ends, contributing to their export, stability and translatability. Recently, a novel class of non‐canonical poly(A) polymerases was discovered in yeast, worms and vertebrates. Different members of the Cid1 family, named after its founding member in the fission yeast Schizosaccharomyces pombe, are localized in the nucleus and the cytoplasm and are thought to target specific RNAs for polyadenylation. Polyadenylation of a target RNA by a Cid1‐like poly(A) polymerase can lead to its degradation or stabilization, depending on the enzyme involved. Cid1‐like proteins have important roles in diverse biological processes, including RNA surveillance pathways, DNA integrity checkpoint responses and RNAi‐dependent heterochromatin formation. Copyright © 2006 John Wiley & Sons, Ltd.
Surface Chemistry of Copper(I) Acetamidinates in Connection with Atomic Layer Deposition (ALD) Processes

The thermal chemistry of copper(I)-N,N′-di-sec-butylacetamidinate on Ni(110) single-crystal and cobalt polycrystalline surfaces was characterized under ultrahigh vacuum (UHV) conditions by X-ray photoelectron spectroscopy (XPS) and temperature-programmed desorption (TPD). A complex network of reactions were identified, starting with the dissociative adsorption of the precursor, from its dimeric form in its free state to a monomer once bonded to the nickel surface. The dissociation of a C–N bond in the acetamidinate ligand at ∼200 K leads to the formation of adsorbed 2-butene and N-sec-butylacetamidinate. Some of the latter intermediates hydrogenate around 300 K to release N-sec-butylacetamidine into the gas phase, while the remaining adsorbed species dissociate further around 400 K, as the copper atoms become reduced to a metallic state, possibly to form acetonitrile and a sec-butylamido surface species that reacts further at 485 K to release 2-butene. By 800 K, only copper and a small amount of carbon ca.
A mixed ionic and electronic conducting dual-phase membrane with high oxygen permeability.

To combine good chemical stability and high oxygen permeability, a mixed ionic-electronic conducting (MIEC) 75 wt% Ce(0.85)Gd(0.1)Cu(0.05)O(2-δ)-25 wt% La(0.6)Ca(0.4)FeO(3-δ)(CGCO-LCF) dual-phase membrane based on a MIEC-MIEC composite has been developed. Copper doping into Ce(0.9)Gd(0.1)O(2-δ) (CGO) oxide enhances both ionic and electronic conductivity, which then leads to a change from ionic conduction to mixed conduction at elevated temperatures. For the first time we demonstrate that an intergranular film with 2-10 nm thickness containing Ce, Ca, Gd, La, and Fe has been formed between the CGCO grains in the CGCO-LCF one-pot dual-phase membrane. A high oxygen permeation flux of 0.70 mL min(-1) cm(-2) is obtained by the CGCO-LCF one-pot dual-phase membrane with 0.5 mm thickness at 950 °C using pure CO2 as the sweep gas, and the membrane shows excellent stability in the presence of CO2 even at lower temperatures (800 °C) during long-term operation.
THE INFLAMMATORY RESPONSE

VASCULAR RESPONSE TO INFLAMMATION 119 Increased Vascular Permeability. 119 Methods of Estimating Increased Vascular Permeability 119 STRUCTURAL ASPECTS OF INCREASED VASCULAR PERMEABILITY.1 Ultrastructure of the Normal Capillary and Venule.120 Ultrastructure of Abnormally Permeable Capillaries and Venules.122 Molecular Sieving.123 Basement Membrane in Vascular Permeability.124 Filtration Pressure and Increased Permeability. 125 Phagocytic Activity in Stimulated Vascular Endothelium. 126 DIRECT DAMAGE AND CHEMICAL MEDIATORS AS MECHANISMS OF THE INFLAMMATORY RESPONSE . 126 ENDOGENOUS SUBSTANCES IN THE EARLY INFLAMMATORY REACTION. 127 Histamine. 127 Mechanism of Histamine Release . 129 Serotonin. 129 ENDOGENOUS MECHANISMS POSSIBLY RESPONSIBLE FOR THE DELAYED VASCULAR CHANGES OF INJURY. 130 Polypeptides . 130 Permeability-Increasing Globulins (PF/DIL) . 131 Inhibitors. 132 ROLE OF POLYPEPTIDES, PLASMA KININS, KININ-FORMING ENZYMES, AND GLOBULIN PF IN INFLAM-
Comparative evaluation of clinical efficacy of β-tri calcium phosphate (Septodont–RTR)™ alone and in combination with platelet rich plasma for treatment of intrabony defects in chronic periodontitis

Aim: To assess the clinical outcome by comparing β-tri calcium phosphate (Septodont RTR)™ along with platelet rich plasma (PRP) and β-tri calcium phosphate (β-TCP) alone in intrabony defects, by clinical evaluation in a 6-month analysis. Methodology: Ten patients participated in the study. Using a split-mouth design, interproximal bony defects were surgically treated with either platelet rich plasma (PRP) combined with β-tri calcium phosphate (β-TCP) or β-TCP alone. Plaque Index (PI), Gingival Index, Probing Pocket Depth (PPD), Clinical Attachment Level (CAL) were recorded 6 months after surgery. Results: At 6 months after therapy, the PRP combined with β-TCP group showed mean PPD reduction of 2.50, CAL mean gain of 2.60 + 1.43. The β-TCP group showed mean PPD reduction of 2.80 mm, mean CAL gain of 2.60 mm. On intra-group comparison, there was greater PPD reduction and CAL gain at 6 months in both the groups. In intergroup comparison of PRP/β-TCP and β-TCP alone, there was no statistical significant difference observed. (P = 0.55, and 0.87 for PPD and CAL gain). Conclusion: Both therapies resulted in significant PPD reduction, CAL gain. The present study shows that treatment of intrabony periodontal defects with combination of PRP and β-TCP does not have additional improvements when compared with β-TCP alone within 6 months follow-up.
Air pollution and childhood cancer: A review of the epidemiological literature

The authors evaluated support in the literature for the hypothesis that ambient air pollution causes childhood cancer. The PubMed database was searched for original articles, which were reviewed for evidence of a relation with the main types of childhood cancer, using criteria including sample size, magnitude and precision of relative risk estimates, presence of a dose–response pattern and potential for bias. The hypothesis has been studied almost entirely with respect to traffic‐related air pollution. Since derivation of the hypothesis from 2 case–control studies in Denver, USA, two further case–control studies have provided new positive evidence and 4 case–control and 7 ecological studies mainly negative evidence. The 4 case–control studies providing positive evidence were relatively small and tended to have more methodological limitations than those showing no association. Publication bias is possible. The weight of the epidemiological evidence indicates no increased risk for childhood cancer associated with exposure to traffic‐related residential air pollution. Nevertheless, the limited number of studies, the methodological limitations of both positive and negative studies and the absence of consistency in the results obviate a firm conclusion of no effect. In particular, nondifferential misclassification of exposure might have masked true, weak associations. © 2006 Wiley‐Liss, Inc.
Alternative diagnosis other than pulmonary embolism as a subjective variable in the Wells clinical decision rule: not so bad after all

PTS of the upper extremity in children should consider this normal variation, and a difference of 2% should not be viewed as clinically significant. In addition, our data show that many children also have superficial veins apparent on visual inspection. Therefore, the Vein Prominence Scale used in this study should be modified to reflect that a finding of grade 1 or 2 visible veins unilaterally may be an unreliable indicator of PTS affecting the upper extremity. Arm pain appeared to be a rare complaint in healthy children (with only 2% having reports of pain), although it is a common symptom in patients with a history of DVT likely to have PTS [6]. This study is limited by the fact that one investigator took all themeasurements, sowewere unable to test the reliability of the Vein Prominence Scale. In addition, our scale was arbitrarily developed,basedonour experience assessingpatientswithDVT orwithCVCsat risk of havingunderlyingDVT [10]. Finally,we did not correlate our findings with similar examination of the children s lower extremities. Nevertheless, this is the first study reporting the normal variation in PTS measurements among childrenof variousages, race/ethnicities andweights.The results should help provide a framework for clinical care and for the design and execution of future studies in children and adults at risk of upper venous system DVT and PTS.
Predicting Depression for Japanese Blog Text

This study aims to predict clinical depression, a prevalent mental disorder, from blog posts written in Japanese by using machine learning approaches. The study focuses on how data quality and various types of linguistic features (characters, to-kens, and lemmas) affect prediction outcome. Depression prediction achieved 95.5% accuracy using selected lemmas as features.
Allelotype of uterine cancer by analysis of RFLP and microsatellite polymorphisms: Frequent loss of heterozygosity on chromosome arms 3p, 9q, 10q, and 17p

Cancers in which mutations have been identified in putative tumor suppressor genes, such as the TP53 gene, the retinoblastoma (RBI) gene, the adenomatous polyposis coli (APC) gene, and the Wilms tumor (WTI) gene, frequently show loss of the corresponding allele on the homologous chromosome. To identify locations of tumor suppressor genes involved in uterine cancer, we examined loss of heterozygosity (LOH) by using genomic probes detecting RFLPs in 35 uterine cancers at 29 loci throughout the genome, and with highly informative microsatellite markers in 21 uterine cancers at nine putative or known tumor suppressor gene loci. High frequencies of allelic loss found at loci on 3p (71%), 9q (38%). 10q (35%). and 17p (35%) suggest that tumor suppressor genes involved in uterine carcinogenesis exist in these regions. There were no significant differences in frequencies of LOH between cancers of the uterine cervix and cancers of the uterine endometrium at any of the loci tested. Genes Chrom Cancer 9:119‐123 (1994). © 1994 Wiley‐Liss, Inc.
Comparison of two educational interventions on pediatric resident auscultation skills.

OBJECTIVE Multiple cross-sectional physician surveys have documented poor cardiac auscultation skills. We evaluated the impact of 2 different educational interventions on pediatric resident auscultation skills. METHODS The auscultation skills of all first-year (PGY1; n = 20) and second-year pediatric residents (PGY2; n = 20) were evaluated at the beginning and end of the academic year. Five patient recordings were presented: atrial septal defect, ventricular septal defect, pulmonary valve stenosis, bicuspid aortic valve with insufficiency, and innocent murmur. Residents were asked to classify the second heart sound, identify a systolic ejection click, describe the murmur, and provide a diagnosis. All PGY1 and most PGY2 (14 of 20) participated on the inpatient cardiology service for 1 month. PGY2 on the cardiology service also attended outpatient clinic. PGY1 did not attend outpatient clinic but were allotted 2 hours/week to use a self-directed cardiac auscultation computer teaching program. RESULTS Resident auscultation skills on initial evaluation were dependent on training level (PGY1: 42 +/- 15% correct; PGY2: 53 +/- 13% correct), primarily as a result of better classification of second heart sound (PGY1: 45%; PGY2: 63%) and diagnosis of an innocent murmur (PGY1: 35%; PGY2: 65%). There was no difference in the ability to identify correctly a systolic ejection click (20% vs 23%) or to arrive at the correct diagnosis (35% vs 40%). At the end of the academic year, the PGY1 scores improved by 21%, primarily as a result of improved diagnostic accuracy of the innocent murmur (35% to 65%). PGY2 scores remained unchanged (53% vs 51%), regardless of participation in a cardiology rotation (cardiology rotation: 50%; no cardiology rotation: 51%). Combined, diagnostic accuracy was best for ventricular septal defect (55%) and innocent murmur (60%) and worst for atrial septal defect (18%) and pulmonary valve stenosis (15%). However, 40% identified the innocent murmur as pathologic and 21% of pathologic murmurs were diagnosed as innocent. CONCLUSIONS Pediatric resident auscultation skills were poor and did not improve after an outpatient cardiology rotation. Auscultation skills did improve after the use of a self-directed cardiac auscultation teaching program. These data have relevance given the American College of Graduate Medical Education's emphasis on measuring educational outcomes and documenting clinical competencies during residency training.
Profile and outcome of patients with acute toxicity admitted in intensive care unit: Experiences from a major corporate hospital in urban India

Background and Aim: There is scarcity of data from the Indian subcontinent regarding the profile and outcome of patients presenting with acute poisoning admitted to intensive care units (ICU). We undertook this retrospective analysis to assess the course and outcome of such patients admitted in an ICU of a tertiary care private hospital. Methods: We analyzed data from 138 patients admitted to ICU with acute poisoning between July 2006 and March 2009. Data regarding type of poisoning, time of presentation, reason for ICU admission, ICU course and outcome were obtained. Results: Seventy (50.7%) patients were males and majority (47.8%) of admissions were from age group 21 to 30 years. The most common agents were benzodiazepines, 41/138 (29.7%), followed by alcohol, 34/138 (24.63%) and opioids, 10/138 (7.2%). Thirty-two (23%) consumed two or more agents. Commonest mode of toxicity was suicidal (78.3%) and the route of exposure was mainly oral (97.8%). The highest incidence of toxicity was due to drugs (46.3%) followed by household agents (13%). Organ failure was present in 67 patients (48.5%). During their ICU course, dialysis was required in four, inotropic support in 14 and ventilator support in 13 patients. ICU mortality was 3/138 (2.8%). All deaths were due to aluminium phosphide poisoning. Conclusions: The present data give an insight into epidemiology of poisoning and represents a trend in urban India. The spectrum differs as we cater to urban middle and upper class. There is an increasing variety and complexity of toxins, with substance abuse attributing to significant number of cases.
Predictors of time to institutionalization of patients with Alzheimer's disease

We studied the time to institutionalization (or death as the first event) in 727 white patients with Alzheimer's disease (AD) enrolled in the Consortium to Establish a Registry for Alzheimer's disease (CERAD). At the time of analysis, 417 patients had been admitted to nursing homes and 32 others had died without previous institutionalization. The major predictors of time to first event were sex, age, marital status (men only), and severity of dementia at entry into the study, as measured by activities of daily living, the Mini-Mental State Examination, and the Clinical Dementia Rating scale. The overall median time from enrollment in the study to first event was 3.1 years. For unmarried men, the median time was significantly less (2.1 years) than for either married men or for married or unmarried women, all of whom had medians greater than 3 years. In an analysis of survival time following institutionalization, we found that men survived a median of 2.1 years, compared with 4.5 years for women. This nationwide study of AD largely confirms earlier studies that reported on smaller numbers of cases from local catchment areas and included patients with various types of dementia.
Revisiting Turnover-Induced Knowledge Loss in Software Projects

In large software projects, tacit knowledge of the system is threatened by developer turnover. When a developer leaves the project, their knowledge may be lost if the other developers do not understand the design decisions made by the leaving developer. Understanding the source code written by leaving developers thus becomes a burden for their successors.In a previous paper, Rigby et al. reported on a case study of turnover-induced knowledge loss in two large projects, Chromium and a project at Avaya, using risk evaluation methods usually applied to financial systems. They found that the two projects were susceptible to large knowledge losses that are more than three times the average loss. We report on a replication of their study on the Chromium project, as well as seven other large and medium-sized open source projects. We also extended theirwork by studying two variations of the knowledge loss metric, as well as the location and persistence of abandoned files.We found that all projects had a similar knowledge loss probability distribution, but extreme knowledge loss can be more severe than those originally discovered in Chromium and the project at Avaya. We also found that, in the systems under study, abandoned files often remained in the system for long periods.
Seroprevalence of Human Immunodeficiency Virus SEROPREVALENCE OF HUMAN IMMUNODIFFICIENCY VIRUS (HIV) AMONGST INMATES OF KADUNA PRISON, NIGERIA

Recent evidence indicate that prison population is at risk of HIV, even though they are one of the most neglected risk group in the area of prevention and management (Joshua 2004). By late 1992, HIV seropositive prisoners had been detected in the Nigeria prisons (Orubuloye et al. 1995). A prevalence of 8.7 %, far higher than the Nation’s average of 6 % was reported for Nigerian prisons (Akpan et al. 2004).
Evaluation des paramètres physiques, chimiques et bactériologiques des eaux d’une lagune tropicale en période d’étiage : la lagune Aghien (Côte d’Ivoire)

Pour pallier le deficit en eau potable du District dfAbidjan, la lagune Aghien est pressentie pour venir en appoint aux champs de captages existants. La presente etude se propose dfameliorer les connaissances sur les qualites physiques, chimiques et bacteriologiques des eaux de cette lagune en periode dfetiage. Certains parametres physiques et chimiques ont ete mesures in situ a lfaide dfappareils multifonctionnels et dfautres ont ete analysees au laboratoire par des methodes hydrochimiques homologuees par lfAgence Francaise de Normalisation (AFNOR). Cette etude montre que les eaux de la lagune Aghien, quasi exclusivement alimentee par les eaux continentales, sont basiques, avec un pH moyen de 7,6 qui denote une activite biologique tres intense dans la lagune. Elles ont une salinite moyenne de 0,03 et une conductivite electrique faible qui varie entre 80,6 et 198,7 ƒES. cm-1. Elles contiennent un faible taux dfoxygene dissous, avec une moyenne de 66,83% et elles sont riches en matieres organiques. Dfimportantes valeurs de DBO5 y ont ete determinees, avec une moyenne de 17,46 mg.L-1. La lagune Aghien est un milieu reducteur, avec un potentiel dfoxydoreduction moyen de - 67,7 mV et ses eaux sont confrontees a une pollution chimique, avec une teneur moyenne en ion ammonium de 23,04 mg.L-1 superieure a la valeur guide de lfOMS (0,05 mg.L-1). Les eaux de cette lagune ont une mauvaise qualite bacteriologique. Elles contiennent par endroit de fortes teneurs en coliformes fecaux (520 UFC/ml) et en coliformes totaux (550 UFC/ml) et elles contiennent egalement des streptocoques fecaux (2 UFC/ml). Mots cles : Lagune Aghien, parametres physiques, parametres chimiques, appareil multifonctionnels, qualite bacteriologique.
Combined Effect of Exercise and Ambient Temperature on Insulin Absorption and Postprandial Glycemia in Type I Patients

We studied the combined effect of cool (10°C) and warm (30°C) ambient temperatures and physical exercise on insulin absorption and postprandial glycemia. Nine type I (insulin-dependent) diabetic patients were injected subcutaneously with their usual morning dose of shortand intermediate-acting human insulin and were given breakfast. Warm temperature was associated with 3- to 5-fold higher insulin absorption (P < .01) and significantly lower blood glucose concentration (P < .001) than cool temperature regardless of exercise. Exercise was associated with 28% (P < .01) and 22% (P < .05) increases in plasma insulin and maximally 5.7 mM (P < .025) and 7.1 mM (P < .01) lower blood glucose at cool and warm temperatures, respectively. Warm temperature and exercise had an additive effect in stimulating insulin absorption and in lowering blood glucose concentrations. However, there was no evidence of synergism between higher temperature and exercise in increasing free-insulin concentrations or decreasing blood glucose concentrations. To avoid postprandial hyperglycemia at cool temperature or hypoglycemia after exercise at warm temperature, appropriate adjustments in diet and insulin dose, or both, should be made.
Alternative splicing in the human gene for the core protein A1 generates another hnRNP protein.

The human hnRNP core protein A1 (34 kd) is encoded by a 4.6 kb gene split into 10 exons. Here we show that the A1 gene can be differentially spliced by the addition of an extra exon. The new transcript encodes a minor protein of the hnRNP complex, here defined A1B protein, with a calculated mol. wt of 38 kd, that coincides with a protein previously designated as B2 by some authors. In vitro translation of the mRNAs selected by hybridization with A1 cDNA produced two proteins of 34 and 38 kd; Northern blot analysis of poly(A)+ RNA from HeLa cells revealed that the abundance of the A1B mRNA was approximately 5% that of A1. The A1B protein was detected by Western blotting with an anti‐A1 monoclonal antibody both in enriched preparations of basic hnRNP proteins and in 40S hnRNP particles. The A1B protein exhibits a significantly higher affinity than A1 for ssDNA. The recombinant A1B protein, expressed in Escherichia coli, shows the same electrophoretic mobility and charge as the cellular one.