Miracle-dz/UniFAR-FTUs huggingface dataset:
Psychometric Properties of the SCARED in a Nationally Representative U.S. Sample of 5–12-Year-Olds

Objective: To examine the factor structure of the Screen for Child Anxiety Related Emotional Disorders – Parent Report (SCARED-P) in young children and elucidate normative levels of parent-reported anxiety using a nationally representative sample of parents of children ages 5–12 years living in the United States. Method: The 41-item SCARED-P was administered to parents of 1,570 youth who were selected to match the U.S. population on key demographic variables. SCARED-P model fit and mean score differences by age, race/ethnicity, and sex were assessed. Results: SCARED-P model fit and subscale reliability appeared almost identical in younger children (ages 5–8) and older children (ages 9–12), although model fit for a five-factor model was poor in both groups. Symptoms of generalized anxiety increased from age 5 to 12, while symptoms of separation anxiety disorder decreased. Parents reported significantly more symptoms of social anxiety in females than males. No significant differences by race/ethnicity were found for mean levels of anxiety or model fit. Conclusions: The SCARED-P shows some utility as an anxiety screening instrument in a representative sample of U.S. youth as young as 5-years-old, but caution should be used when interpreting subscale scores.
Clinical experience with array CGH: Case presentations from nine months of practice

A total of 124 individuals were tested in the initial 9 months that array CGH technology was offered to clinical genetics patients. In 11 of these patients array CGH identified a previously unsuspected diagnosis. A suspected diagnosis was confirmed in three patients. A single case in this series proved to be a polymorphic copy number variant. This paper describes five of the patients with previously unsuspected diagnoses in detail. We suggest that array CGH is an improved tool ready for routine use in clinical genetics. © 2006 Wiley‐Liss, Inc.
Association between number of sexual partners and utilization of family planning and sexually transmitted infection services by men aged 15–44 in the United States

Abstract Unintended pregnancy and sexually transmitted infections (STIs) pose a huge public health problem in the United States. Efforts towards reducing unintended pregnancies have previously focused on women, but the role of men in family planning and preventing unwanted pregnancy is becoming clearer. The primary objective of the study was to fully examine the utilization of family planning services by men in the US, and to determine whether factors such as race, health insurance type and number of sexual partners influenced their utilization and receipt of family planning services and STI-related health services. Data were from the 2006–2010 National Survey on Family Growth (NSFG) study conducted in the US. The study sample comprised 7686 men aged 14–44 who ever had sex with women, and who had had at least one sexual partner in the 12 months before the survey. The receipt of family planning and STI-related health services by this group of men was estimated. The results showed that non-Hispanic Black men were more likely to receive family planning and STI-related services than Hispanic and non-Hispanic White males. Given that non-Hispanic Black men are disproportionately affected by STIs and are a high-risk group, the finding that this group received more family planning and STI services is a positive step towards reducing the disproportionately high prevalence of STIs in men in this under-privileged population.
Elimination of the Photodarkening Effect in an Yb-Doped Fiber Laser With Deuterium

This study reports the radical elimination of the photodarkening (PD)-effect in Yb-doped fiber through deuterium loading. With deuterium pre-loading, no PD-induced excess loss of the Yb-doped fiber was observed under 915-nm pumping conditions. Moreover, the existing loss induced by the PD effect was also eliminated via deuterium loading, and the excess loss declined to nearly 0 dB/m. The method was also validated in a KW-level fiber laser experimental setup. In the 20/400-μm deuterium pre-loaded Yb-doped fiber, an output laser power of 1630 W and beam quality factor (M2) of 1.69 were obtained. The two parameters remained stable during the entire continuous operation process of 40 min, and displayed very little power fluctuation of <0.5%. The results of our experiments confirmed that deuterium loading can protect Yb-doped fibers from the PD effect, thereby improving the power and mode stability, which is often deteriorated by PD. Notably, the results of this study are beneficial in terms of further development of high-power fiber lasers.
Variant Salmonella Genomic Island 1-L Antibiotic Resistance Gene Cluster in Salmonella enterica Serovar Newport

ABSTRACT We report a new Salmonella genomic island 1 variant antibiotic resistance gene cluster called SGI1-L in a Salmonella enterica serovar Newport isolate containing a dfrA15 gene cassette conferring resistance to trimethoprim. The isolate carried another class 1 integron containing the aacC5 and aadA7 gene cassettes conferring resistance to gentamicin and streptomycin/spectinomycin, respectively.
Chlamydiaceae: Diseases in Primary Hosts and Zoonosis

Bacteria of the Chlamydiaceae family are a type of Gram-negative microorganism typified by their obligate intracellular lifestyle. The majority of the members in the Chlamydiaceae family are known pathogenic organisms that primarily infect the host mucosal surfaces in both humans and animals. For instance, Chlamydia trachomatis is a well-known etiological agent for ocular and genital sexually transmitted diseases, while C. pneumoniae has been implicated in community-acquired pneumonia in humans. Other chlamydial species such as C. abortus, C. caviae, C. felis, C. muridarum, C. pecorum, and C. psittaci are important pathogens that are associated with high morbidities in animals. Importantly, some of these animal pathogens have been recognized as zoonotic agents that pose a significant infectious threat to human health through cross-over transmission. The current review provides a succinct recapitulation of the characteristics as well as transmission for the previously established members of the Chlamydiaceae family and a number of other recently described chlamydial organisms.
Feedback Control Applications in New Radio: Exploring Delay Control and Alignment

In a new radio (NR) communication system, low latency and limited jitter are critical to support new use cases exploiting haptic feedback and other closed-loop feedback control applications. Therefore, mechanisms for delay control and delay alignment are important. The simplest approaches to mitigating delay jitter, using buffering techniques, come at the price of memory and increased delay. More recently, techniques using feedback of delays experienced have shown great promise for improved performance with low overhead. The scope of this article is to discuss and motivate recognition of the need for delay alignment in general.
Rapamycin retards epigenetic ageing of keratinocytes independently of its effects on replicative senescence, proliferation and differentiation

The advent of epigenetic clocks has prompted questions about the place of epigenetic ageing within the current understanding of ageing biology. It was hitherto unclear whether epigenetic ageing represents a distinct mode of ageing or a manifestation of a known characteristic of ageing. We report here that epigenetic ageing is not affected by replicative senescence, telomere length, somatic cell differentiation, cellular proliferation rate or frequency. It is instead retarded by rapamycin, the potent inhibitor of the mTOR complex which governs many pathways relating to cellular metabolism. Rapamycin, however, is also an effective inhibitor of cellular senescence. Hence cellular metabolism underlies two independent arms of ageing – cellular senescence and epigenetic ageing. The demonstration that a compound that targets metabolism can slow epigenetic ageing provides a long-awaited point-of-entry into elucidating the molecular pathways that underpin the latter. Lastly, we report here an in vitro assay, validated in humans, that recapitulates human epigenetic ageing that can be used to investigate and identify potential interventions that can inhibit or retard it.
Enhancement of Complex Permittivity and Attenuation Properties of Recycled Hematite (α-Fe2O3) Using Nanoparticles Prepared via Ball Milling Technique

The purpose of this study was to synthesize high-quality recycled α-Fe2O3 to improve its complex permittivity properties by reducing the particles to nanosize through high energy ball milling. Complex permittivity and permeability characterizations of the particles were performed using open-ended coaxial and rectangular waveguide techniques and a vector network analyzer. The attenuation characteristics of the particles were analyzed with finite element method (FEM) simulations of the transmission coefficients and electric field distributions using microstrip model geometry. All measurements and simulations were conducted in the 8–12 GHz range. The average nanoparticle sizes obtained after 8, 10 and 12 h of milling were 21.5, 18, and 16.2 nm, respectively, from an initial particle size of 1.73 µm. The real and imaginary parts of permittivity increased with reduced particle size and reached maximum values of 12.111 and 0.467 at 8 GHz, from initial values of 7.617 and 0.175, respectively, when the particle sizes were reduced from 1.73 µm to 16.2 nm. Complex permeability increased with reduced particle size while the enhanced absorption properties exhibited by the nanoparticles in the simulations confirmed their ability to attenuate microwaves in the X-band frequency range.
Can a Virtual Human Facilitate Language Learning in a Young Baby?

There is a significant paucity of work on language learning systems for young infants [2, 5, 19] despite the widely understood critical importance that this developmental period has for healthy language and cognitive growth, and related reading and academic success [6, 14]. Deaf babies constitute one vulnerable population as they can experience dramatically reduced or no access to usable linguistic input during this period [18]. This causes potentially devastating impact on children's linguistic, cognitive, and social skills [9, 10, 15, 16, 20]. We introduced an AI system, called RAVE (Robot, AVatar, thermal Enhanced language learning tool), designed specifically for babies within the age range of 6-12 months [8, 17]. RAVE consists of two agents: a virtual human (provides language and socially contingent interactions) and an embodied robot (provides socially engaging physical cues to babies and directs babies' attention to the virtual human). Detailed description of the system's constituent components and dialogue algorithms are presented in [17] and [8].
Robot Learning by Collaborative Network Training: A Self-Supervised Method using Ranking

We introduce Collaborative Network Training -- a self-supervised method for training neural networks with aims of: 1) enabling task objective functions that are not directly differentiable w.r. t. the network output; 2) generating continuous-space actions; 3) more direct optimization for achieving a desired task; 4) learning parameters when a process for measuring performance is available, but labeled data is unavailable. The procedure involves three randomly initialized independent networks that use ranking to train one another on a single task. The method incorporates qualities from ensemble and reinforcement learning as well as gradient free optimization methods such as Nelder-Mead. We evaluate the method against various baselines using a variety of robotics-related tasks including inverse kinematics, controls, and planning in both simulated and real-world environments.
Reprogramming Efficiency Following Somatic Cell Nuclear Transfer Is Influenced by the Differentiation and Methylation State of the Donor Nucleus

Reprogramming of a differentiated cell nucleus by somatic cell nuclear transplantation is an inefficient process. Following nuclear transfer, the donor nucleus often fails to express early embryonic genes and establish a normal embryonic pattern of chromatin modifications. These defects correlate with the low number of cloned embryos able to produce embryonic stem cells or develop into adult animals. Here, we show that the differentiation and methylation state of the donor cell influence the efficiency of genomic reprogramming. First, neural stem cells, when used as donors for nuclear transplantation, produce embryonic stem cells at a higher efficiency than blastocysts derived from terminally differentiated neuronal donor cells, demonstrating a correlation between the state of differentiation and cloning efficiency. Second, using a hypomorphic allele of DNA methyltransferase‐1, we found that global hypomethylation of a differentiated cell genome improved cloning efficiency. Our results provide functional evidence that the differentiation and epigenetic state of the donor nucleus influences reprogramming efficiency.
Genotyping of Type A Human Respiratory Syncytial Virus Based on Direct F Gene Sequencing

Background and objectives: The human respiratory syncytial virus (hRSV) is among the important respiratory pathogens affecting children. Genotype-specific attachment (G) gene sequencing is usually used to determine the virus genotype. The reliability of the fusion (F) gene vs. G gene genotype-specific sequencing was screened. Materials and Methods: Archival RNA from Saudi children who tested positive for hRSV-A were used. Samples were subjected to a conventional one-step RT-PCR for both F and G genes and direct gene sequencing of the amplicons using the same primer sets. Phylogeny and mutational analysis of the obtained sequences were conducted. Results: The generic primer set succeeded to amplify target gene sequences. The phylogenetic tree based on partial F gene sequencing resulted in an efficient genotyping of hRSV-A strains equivalent to the partial G gene genotyping method. NA1, ON1, and GA5 genotypes were detected in the clinical samples. The latter was detected for the first time in Saudi Arabia. Different mutations in both conserved and escape-mutant domains were detected in both F and G. Conclusion: It was concluded that a partial F gene sequence can be used efficiently for hRSV-A genotyping.
Virtual Screening Guided Design, Synthesis and Bioactivity Study of Benzisoselenazolones (BISAs) on Inhibition of c-Met and Its Downstream Signalling Pathways

c-Met is a transmembrane receptor tyrosine kinase and an important therapeutic target for anticancer drugs. In this study, we designed a small library containing 300 BISAs molecules that consisted of carbohydrates, amino acids, isothiourea, tetramethylthiourea, guanidine and heterocyclic groups and screened c-Met targeting compounds using docking and MM/GBSA. Guided by virtual screening, we synthesised a series of novel compounds and their activity on inhibition of the autophosphorylation of c-Met and its downstream signalling pathway proteins were evaluated. We found a panel of benzisoselenazolones (BISAs) obtained by introducing isothiourea, tetramethylthiourea and heterocyclic groups into the C-ring of Ebselen, including 7a, 7b, 8a, 8b and 12c (with IC50 values of less than 20 μM in MET gene amplified lung cancer cell line EBC-1), exhibited more potent antitumour activity than Ebselen by cell growth assay combined with in vitro biochemical assays. In addition, we also tested the antitumour activity of three cancer cell lines without MET gene amplification/activation, including DLD1, MDA-MB-231 and A549. The neuroblastoma SK-N-SH cells with HGF overexpression which activates MET signalling are sensitive to MET inhibitors. The results reveal that our compounds may be nonspecific multitarget kinase inhibitors, just like type-II small molecule inhibitors. Western blot analysis showed that these inhibitors inhibited autophosphorylation of c-MET, and its downstream signalling pathways, such as PI3K/AKT and MARK/ERK. Results suggest that bensoisoselenones can be used as a scaffold for the design of c-Met inhibiting drug leads, and this study opens up new possibilities for future antitumour drug design.
The Role of Work Environment in Training Sustainment: A Meta-Analysis

Objective: The purpose of this meta-analytic review is to examine the role of three work environment support variables (i.e., peer, supervisor, and organizational support) in training transfer and sustainment or long-term use of learned knowledge, skills, and attitudes (KSAs). Background: Estimates demonstrate that little training is transferred to the job, wasting billions in organizational spending each year and resulting in significant loss to safety and individual and team performance. Prior research shows the importance of a supportive work environment to facilitating transfer; however, we know little of the relative importance of specific support variables. This study seeks to examine the unique roles of distinct support variables in training transfer. Method: A meta-analysis was conducted with multiple regressions to answer three primary research questions. Results: All work environment support variables demonstrate moderate and positive correlations with transfer of training. Furthermore, multiple regressions demonstrate that each factor of the work environment explains unique variance as a predictor, with the model accounting for 32% of transfer and peer support accounting for most of R2. Motivation to transfer mediates the relationship between all three work environment support variables and transfer. Furthermore, three support variables are positively related to sustainment, with peer and supervisor support showing the strongest relationships. Conclusion: Findings illuminate the relative contribution of peer, supervisor, and organizational support to transfer and sustainment of training. As transfer continues to be an important yet understudied measure of the effectiveness of workplace training, these findings hold implications for both research and practice.
High Life Satisfaction: Exploring the Role of Health, Social Integration and Perceived Safety among Mexican Midlife and Older Adults

ABSTRACT We sought to investigate the relationship of high life satisfaction with important physical health, mental health, social integration and perceived safety factors among midlife and older Mexican adults. We examined 2,200 midlife and older adults (aged 50–101 years) from the Mexican arm of the Study on global AGEing and adult health (SAGE) and used binary logistic regression models to identify key factors associated with high LSA. Our final logistic regression model revealed self-rated health, affect, interpersonal activities and perceived safety on street to be significantly associated with high life satisfaction. Results from this study add to the nascent literature on subjective well-being of midlife and older Mexicans. Although social work with older adults is not well established in Mexico, researchers and practitioners should collaborate on the development and implementation of social worker-led strategies for prevention and intervention to enhance well-being among midlife and older Mexicans.
Magnetic Resonance Spectroscopy Study of Amnestic Mild Cognitive Impairment and Vascular Cognitive Impairment With No Dementia

Amnestic mild cognitive impairment (aMCI) and vascular cognitive impairment with no dementia (VCIND) are highly predictive of Alzheimer’s disease and vascular dementia. In this study, a 2-dimensional magnetic resonance spectroscopy was performed in 25 patients with aMCI, 28 patients with VCIND, and 32 normal controls (NCs). The concentrations of N-acetyl aspartate (NAA), choline (Cho), myoinositol (MI), and creatine (Cr) were measured, and their ratios were calculated. The patients with aMCI displayed significantly lower NAA/MI bilaterally in the posterior cingulate gyrus (PCG) and white matter of occipital lobe (OLWM) than NC participants or patients with VCIND , whereas patients with VCIND displayed markedly lower NAA/Cho bilaterally in the white matter of frontal lobe (FLWM) and left OLWM, and right dorsal thalamus (DT) than patients with NC or aMCI. Compared with the controls, patients with aMCI displayed lower NAA and NAA/Cr in bilateral PCG, left precuneus, and DT, whereas patients with VCIND displayed lower NAA/Cr in bilateral DT and FLWM. In addition, increased MI in right PCG of patients with aMCI and increased Cho in left FLWM of patients with VCIND were also observed. The results might help guide a clinical differentiation between the 2 disorders.
A Comparative Study on Johnson Cook, Modified Zerilli–Armstrong, and Arrhenius-Type Constitutive Models to Predict Compression Flow Behavior of SnSbCu Alloy

The flow behavior of the SnSbCu alloy is studied experimentally by the compression tests in the range of the strain rates from 0.0001 to 0.1 s−1 and temperature from 293 to 413 K. Based on the experimental data, three constitutive models including the Johnson–Cook (J–C), modified Zerilli–Armstrong (Z–A), and Arrhenius-type (A-type) models are compared to find out an optimum model to describe the flow behavior of the SnSbCu alloy. The results show that the J–C model could predict the flow behavior of the SnSbCu alloy accurately only at some specific strain rates and temperature near the reference values. The modified Z–A and A-type constitutive models can give better fitting results than the J–C model. While, at high strains, the predictive values of the modified Z–A model have larger errors than those at low strains, which means this model has limitations at high strains. By comparison, the A-type model could predict the experimental results accurately at the whole strain range, which indicates that it is a more suitable choice to describe the flow behavior of the SnSbCu alloy in the focused range of strain rates and temperatures. The work is beneficial to solve the tribological problem of the bearing of the marine engine by integrating the accurate constitutive model into the corresponding numerical model.
Minority protection and information content of dividends in Finland

This paper highlights some theoretical arguments and empirical results on whether legal-based minority protection affects information content of dividends in Finland. In Finland minority protection applies only in profitable years. I find, that minority protection (as in Finland) decreases information content of positive dividend changes and increases information content of negative dividend changes. When dividend cash flows exceed minority dividend (because minority shareholders have utilized minority protection), information content of dividend disappears concerning both positive and negative dividend changes. The result suggests that minority protection (as in Finland) decreases information content of dividends.