Miracle-dz/UniFAR-FTUs huggingface dataset:
Esophageal eosinophilic disease after intestinal transplantation in children.

This work was supported by a Fondazione Cariparma grant entitled ‘‘Transplantation tolerance: immunological mechanisms and new biomarkers. ’’ The authors declare no conflicts of interest. Address correspondence to: Augusto Vaglio, M.D., Ph.D., Unità Operativa di Nefrologia, Azienda Ospedaliero-Universitaria di Parma, Via Gramsci 14, 43126 Parma, Italy. E-mail: augusto.vaglio@virgilio.it C.D. B. collected and analyzed data and drafted the article. U.M. contributed to study design and performed statistical analysis. A.P., L.B. , and C.B. contributed to data collection, patient management and critical revision of the article. A.V. was involved in study design, data analysis and interpretation, and wrote the final version of the article. Received 14 February 2014. Accepted 1 May 2014. Copyright * 2014 by Lippincott Williams & Wilkins ISSN: 0041-1337/14/9803-00 DOI: 10.1097/TP.0000000000000277
Causal Modeling of Web-Advertising Effects by Improving SEM Based on DEMATEL Technique

Causal analysis greatly affects the efficiency of decision-making. Scholars usually adopt structural equation modeling (SEM) to establish a causal model recently. However, statistical data allow researchers to modify the model frequently to arrive at good model fitness, and SEM is often misapplied when the data are merely fitted to an SEM and the theory is then extended from the analytical result based on presumed hypotheses. This paper proposed SEM modified by DEMATEL technique, taking causal model of Web-advertising effects for example. Having revealed that the new model is the one that conforms to actual data and is better than initial model, the results confirm that the DEMATEL technique can be an efficient, complementary, and confident approach for reprioritization of the amended modes in a SEM model. In addition, the most important factor affecting the Web-advertising effects may be found via the modified model, which benefits the manager for making strategic marketing plans.
Muscle activation strategies at the knee during running and cutting maneuvers.

PURPOSE The purpose of this article was to investigate the activation patterns of muscles surrounding the knee during preplanned (PP) and unanticipated (UN) running and cutting tasks, with respect to the external moments applied to the joint. It was hypothesized that activation strategies during PP tasks would correspond to the magnitude and direction of the external loads applied to the knee joint, and the muscle activation patterns would differ between PP and UN tasks. METHODS Eleven healthy male subjects performed a series of running and cutting tasks under PP and UN conditions. Activation from 10 knee muscles were determined using full-wave rectified, filtered, and normalized EMG calculated during a precontact phase and two epochs across the stance phase. Knee joint flexor and extensor muscle group ratios indicated the level of co-contraction. Individual muscles were also grouped into medial/lateral and internal/external rotation muscle groups, based upon their ability to counter externally applied varus/valgus and internal/external rotation joint loads, respectively. RESULTS Selective activation of medial/lateral and internal/external rotation muscles and co-contraction of flexors and extensors were used to stabilize the joint under PP conditions, whereas generalized co-contraction strategies were employed during the UN condition. Net muscle activation during the UN sidestepping tasks increased by 10-20%, compared with an approximately 100% increase in applied varus/valgus and internal/external rotation joint moments. CONCLUSION In PP conditions, activation patterns appear to be selected to support the external loads experienced at the knee, e.g., medial muscles activated to resist applied valgus moments. Under UN conditions, there was no selective activation of muscles to counter the external knee load, with generalized co-contraction being the activation pattern adopted. These findings have implications for the etiology of noncontact knee ligament injuries.
Cooperative learning in Forestry Engineering with NIPPE Descartes software

This work describes the methodology, procedure, and results obtained from the application of an education co‐operative learning experience with NIPPE Descartes software in a specific task. Students in the second year of a degree course in Forestry Engineering at the Madrid Polytechnic University were invited to take part in a peer‐learning experience. The students were organized in pairs and asked to complete an optional task in one of the modules in the subject of Mechanics. This experience took place between 2006 and 2011. The results were compared with the previous period between 2003 and 2006 in which this task was not required. The students were surveyed to assess their degree of satisfaction and the contribution of the experience to the learning of the subject. This methodology was observed to substantially reduce the percentage of students who do not show up for their evaluation exams, and the percentage of pass and fail marks also reveals significant differences. Additionally, of the students who performed the task, the number who passed in the ordinary examination period increased nearly 30% points compared to those who did not. It is worth noting that 43% of the students participating in the experience rated the activity as a fairly or very positive in terms of contributing to learning the subject. © 2017 Wiley Periodicals, Inc. Comput Appl Eng Educ 25:103–111, 2017; View this article online at wileyonlinelibrary.com/journal/cae; DOI 10.1002/cae.21783
Neuropsychological characteristics of young children from high-density alcoholism families: a three-year follow-up.

OBJECTIVE We performed a follow-up study of a group of young children from high-density alcoholism families (HD children), who were first assessed about 3.5 years ago, with the aim of evaluating verbal span and visuospatial abilities (which differed significantly between HD and control [C] children at the first assessment), as well as other neuropsychological measures. METHOD In this second assessment, 22 boys and girls were evaluated. They were comparable in family income and parents' level of education. The 12 HD children had an alcoholic father and at least two other alcoholic relatives, whereas the 10 C children had no family history of alcoholism in either the first or second generation. A neuropsychological battery was set up with standardized tasks to measure attention, memory, visuospatial and executive functions. RESULTS Analysis revealed significant Group x Assessment interactions in the digit span subtest where high-density children increased their performance until it reached that of the control children, and in the Wisconsin Card Sorting Test (WCST) where high-density children did not show the same improvement as the C children with maturation. A main effect was also observed for group factor in perseverative responses of the WCST. CONCLUSIONS High-density children attain the same level of performance as control children for verbal span, but differences between groups increase over time for executive functioning as measured by the WCST. These results are considered in the context of the developmental delay hypothesis. The small sample size, however, means further studies will be necessary to confirm our findings.
Adenosine potentiates flow-induced dilation of coronary arterioles by activating KATP channels in endothelium.

Coronary microvascular diameter is significantly influenced by adenosine and flow. However, the interaction between these two regulatory mechanisms in the control of coronary microvascular tone remains unknown. Because adenosine can activate ATP-sensitive K+ (KATP) channels and these channels are located on the endothelium in addition to vascular smooth muscle, we hypothesized that adenosine can potentiate flow-induced vasodilation by activating endothelial KATP channels in the coronary microcirculation. To test this hypothesis, experiments were performed in porcine subepicardial coronary arterioles (50-150 microns) using isolated, cannulated vessel techniques to allow intraluminal pressure and flow to be independently controlled. All vessels developed active tone, approximately 67-73% of maximum diameter, at 60 cmH2O intraluminal pressure and showed graded dilation to stepwise increases in flow. The magnitude of flow-induced dilation was potentiated by a threshold dose of adenosine (10(-10) M) but not by nitroprusside (10(-10) M). Luminal application of a high K+ concentration ([K+]) (40 mM) completely blocked flow-induced arteriolar dilation. In addition, luminal glibenclamide (10(-6) M) abolished the adenosine-potentiated component of flow-induced response. Indomethacin (10(-5) M) did not alter the dose-dependent dilation to adenosine. However, endothelial denudation, NG-monomethyl-L-arginine (10(-5) M), and luminal administration of a high [K+] or glibenclamide each produced identical inhibition of adenosine-induced vasodilation by shifting the 50% effective dose to the right by an order of magnitude. In contrast, vasodilation in response to nitroprusside was not altered by these pharmacological interventions. (ABSTRACT TRUNCATED AT 250 WORDS)
Cancer Information Seekers in China: A Preliminary Profile

Cancer is now the leading cause of death in China. Effective communication about cancer risk and prevention is an important component of cancer control. Yet, research in this area is very limited in China. This study used probability sample survey data from 2 Chinese cities (Beijing and Hefei, Anhui Province) to investigate potential predictors of self-initiated cancer information seeking. Analysis showed that cancer information seekers in China were likely to be married, relatively educated, earning modest incomes, living in rural areas, smoking occasionally, having a family cancer history, relatively trusting of the media for health information, somewhat knowledgeable about cancer, having nonfatalistic attitudes about cancer, and seeing a personal need for more cancer information. The pattern of results, particularly the lack of influence of personal health and risk perception factors, highlights the possibility that seeking for others might be more prevalent than seeking for self in China. Overall, findings suggest that emphasizing family need and mobilizing family support might be a productive approach to cancer communication interventions in China.
Influenza A/H1N1 in Pediatric Oncology Patients

Background: Our aim was to determine the clinical and epidemiological features of pandemic influenza A/H1N1 in immunocompromised children with solid tumors and hematological malignancies. Patients and Methods: A prospective study was conducted during the H1N1 pandemic between August 2009 and February 2010 in a pediatric hematology-oncology unit. Demographic and clinical data were obtained from all children with suspected H1N1 infection (high fever with or without respiratory symptoms). Laboratory diagnosis of influenza A/H1N1 was performed by means of polymerase chain reaction analysis of nasopharyngeal wash specimens. Results: We identified 57 episodes of suspected influenza A/H1N1 infection in 40 children. In all episodes, children were treated with oseltamivir and antibiotics until influenza A/H1N1 results were received. Of all episodes, 13 (22.8%) tested positive for influenza A/H1N1. Two of the H1N1-positive children (15.4%) had been previously immunized against influenza A/H1N1. No differences between H1N1-positive and H1N1-negative children were noted in terms of demographic features, clinical presentation, laboratory findings, and underlying disease. Three polymerase chain reaction-positive (23.0%) children and 1 H1N1-negative (2.3%) child were admitted to the pediatric intensive care unit and were mechanically ventilated (P=0.03). One (7.7%) H1N1-positive patient died versus none of the H1N1-negative patients (P=0.2). The condition of all other children in both the groups improved rapidly during hospitalization. Conclusions: Febrile hospitalized pediatric oncology patients, with and without pandemic influenza A/H1N1, had a similar demographic and clinical presentation with a relatively good outcome. This was probably because of early antiviral treatment and possibly because of the relatively low virulence of the virus. Immunization should be encouraged in these patients.
The antecedents of online financial service adoption: the impact of physical banking services on Internet banking acceptance

The cost-effectiveness of operations on the Web enables financial service firms to employ Web technology to replace or substantially reduce the need for personal interactions in the provision of their services. However, recent cases have shown that the use of Web technology in financial services may not be as promising as expected. This study utilises the constructs derived from transaction cost analysis (TCA), the technology acceptance model (TAM) and relationship marketing literature to develop a framework of the antecedents to using Internet banking. The model explicitly incorporates the impact of the experiences a customer has had with services provided by the physical bank whose Web services the customer is considering using. The results show that the major antecedent variables in TAM and the customers’ specific assets already invested in the focal physical bank have a significant impact on customers’ attitude towards the use and the intention to use a bank's Internet banking services. Our findings suggest that beyond the ease of use and usefulness of information system, companies have to take advantage of customer relationship built up in the offline environment that has the potential to influence customers’ use intention towards Internet service. The study advances the technology acceptance literature in terms of explaining users’ new-service-adoption behaviour by adding the concepts from TCA and customer relationship literature.
CEPHRADINE AND FLUCLOXACILLIN IN THE PROPHYLAXIS OF INFECTION IN PATIENTS WITH OPEN FRACTURES

A comparison of prophylactic antibiotic cover of cephradine or fiucloxacillin in sixty patients with open fractures is reported. There were more infections in the fiucloxacillin than in the cephradine group and gastrointestinal side‐effects were more common. The overall incidence of infection in the whole group, two out of 60 or 3·3%, was acceptably low.
Impact of the MRN Complex on Adeno-Associated Virus Integration and Replication during Coinfection with Herpes Simplex Virus 1

ABSTRACT Adeno-associated virus (AAV) is a helper-dependent parvovirus that requires coinfection with adenovirus (AdV) or herpes simplex virus 1 (HSV-1) to replicate. In the absence of the helper virus, AAV can persist in an episomal or integrated form. Previous studies have analyzed the DNA damage response (DDR) induced upon AAV replication to understand how it controls AAV replication. In particular, it was shown that the Mre11-Rad50-Nbs1 (MRN) complex, a major player of the DDR induced by double-stranded DNA breaks and stalled replication forks, could negatively regulate AdV and AAV replication during coinfection. In contrast, MRN favors HSV-1 replication and is recruited to AAV replication compartments that are induced in the presence of HSV-1. In this study, we examined the role of MRN during AAV replication induced by HSV-1. Our results indicated that knockdown of MRN significantly reduced AAV DNA replication after coinfection with wild-type (wt) HSV-1 or HSV-1 with the polymerase deleted. This effect was specific to wt AAV, since it did not occur with recombinant AAV vectors. Positive regulation of AAV replication by MRN was dependent on its DNA tethering activity but did not require its nuclease activities. Importantly, knockdown of MRN also negatively regulated AAV integration within the human AAVS1 site, both in the presence and in the absence of HSV-1. Altogether, this work identifies a new function of MRN during integration of the AAV genome and demonstrates that this DNA repair complex positively regulates AAV replication in the presence of HSV-1. IMPORTANCE Viral DNA genomes trigger a DNA damage response (DDR), which can be either detrimental or beneficial for virus replication. Adeno-associated virus (AAV) is a defective parvovirus that requires the help of an unrelated virus such as adenovirus (AdV) or herpes simplex virus 1 (HSV-1) for productive replication. Previous studies have demonstrated that the cellular Mre11-Rad50-Nbs1 (MRN) complex, a sensor and regulator of the DDR, negatively regulates AAV replication during coinfection with AdV, which counteracts this effect by inactivating the complex. Here, we demonstrate that MRN positively regulates AAV replication during coinfection with HSV-1. Importantly, our study also indicates that MRN also favors integration of AAV genomes within the human AAVS1 site. Altogether, this work indicates that MRN differentially regulates AAV replication depending on the helper virus which is present and identifies a new function of this DNA repair complex during AAV integration.
Uveitis in Children: Diagnosis and Management

Uveitis encountered in a pediatric patient is always accompanied by a level of anxiety for the treating clinician. This is so in part because of the uncommonness of pediatric uveitis—even more uncommon than in adult patients. There are fewer cases of uveitis in the pediatric population than would be predicted if there were an even age distribution among uveitis patients. Case series estimate that children account for only 6% to 10% of patients seen in uveitis clinics. This rarity has resulted in relatively little information about pediatric uveitis in the literature. Another reason for the higher anxiety provoked by pediatric uveitis patients is the practical difficulties that surround caring for the child. Patient history and symptoms are critically important in the management of the uveitis patient; young children are either unable or unwilling to offer useful histories with regard to recent symptoms. In some instances, uveitis in the pediatric patient is not accompanied by symptoms or signs typically seen in adult patients. Additionally, young children cannot always cooperate with adequate examinations at the slit lamp or the administration of ocular drops. Amblyopia is another concern unique to the uveitis patient in this young age group. Impaired vision for prolonged periods due to active inflammation or cystoid macular edema in adult patients can still be associated with recovery of good vision, whereas in children younger than 7 years, recovery of vision may be limited, particularly if the uveitis is asymmetrical. Finally, the factor that brings the greatest anxiety to the treatment of uveitis in pediatric patients is parental anxiety, which can have profound effects on both the patient and the treating physician. The purpose of this chapter, along with the accompanying chapter in
CYTOLOGICAL QUALITY OF GOAT MILK ON THE BASIS OF THE SOMATIC CELL COUNT

The aim of the present paper was to evaluate the cytological quality of goat milk based on the somatic cell count in respective months of lactation. Besides there was defined the effect of somatic cell on the milk production and chemical composition of milk. The research covered goats of color improved breed in the 2nd and 3rd lactation. Daily milk yield, chemical composition of milk and its somatic cell count were defined based on monthly morning and evening control milkings from both teats, following the A4 method applied in District Animal Evaluation Stations. The research indicated that the greater the somatic cell count in milk, the lower the daily milk yield, however the greater the somatic cell count, the greater the percentage content of fat and dry matter and the lower the content of lactose.
In vitro comparison of a single-layer (continuous Lembert) versus two-layer (simple continuous/Cushing) hand-sewn end-to-end jejunoileal anastomosis in normal equine small intestine.

OBJECTIVES To compare in vitro physical and mechanical characteristics of 1-layer and 2-layer end-to-end jejunoileostomy. STUDY DESIGN In vitro experimental study. ANIMALS Adult horses (n = 6). METHODS Harvested equine jejunum and ileum was used to create 1- and 2-layer end-to-end jejunoileostomy specimens. Construction time, bursting pressure, and relative lumen diameter (anastomosis diameter expressed as a percentage of the lumen diameter of adjacent jejunum and ileum) were compared. Construction time and relative lumen diameters were compared using a paired t-test. Bursting pressure for anastomoses and control jejunal segments were compared using a repeated-measure ANOVA. Statistical significance was set at P < . 05. RESULTS Mean (± SEM) construct completion times were shorter for 1 layer (21 ± 0.91 minutes) than 2 layers (26.71 ± 1.16 minutes; P = .005). Relative lumen diameters (percentage of jejunal diameter) were larger for 1 layer (77.67 ± 4.46%) than for 2 layers (69.37 ± 2.8%; P = .035). There were no significant differences in bursting pressures between the 2 groups and the control jejunum (P =.155) or relative lumen diameters (percentage of ileal diameter; P =.118). CONCLUSIONS One-layer jejunoileostomy can be created in a shorter time and maintain a larger anastomosis luminal diameter without compromising maximum bursting pressure when compared to 2-layer jejunoileostomy.
Deep Ordinal Regression Forests

Ordinal regression is a type of regression techniques used for predicting an ordinal variable. Recent methods formulate an ordinal regression problem as a series of binary classification problems. Such methods cannot ensure the global ordinal relationship is preserved since the relationships among different binary classifiers are neglected. We propose a novel ordinal regression approach called Deep Ordinal Regression Forests (DORFs), which is constructed with the differentiable decision trees for obtaining precise and stable global ordinal relationships. The advantages of the proposed DORFs are twofold. First, instead of learning a series of binary classifiers independently, the proposed method learns an ordinal distribution for ordinal regression. Second, the differentiable decision trees can be trained together with the ordinal distribution in an end-to-end manner. The effectiveness of the proposed DORFs is verified on two ordinal regression tasks, i.e., facial age estimation and image aesthetic assessment, showing significant improvements and better stability over the state-of-the-art ordinal regression methods.
Pathology of Sensorineural Hearing Loss in Otitis Media

The fine structure of the round window membrane has been described by Kawabata and Paparella.9 The membrane has three layers: 1) the epithelial layer, consisting of nonciliated flat cells contiguous with the middle ear lining; 2 ) the middle layer (immediately beneath the basement membrane of the epithelial layer), in which fibrocytes with extensions form a network of continuous cells with large intercellular spaces filled with collagen and elastic ---fibers; and 3) the inner layer (facing the scala tympani) consisting of elongated thin cells with thin cytoplasmic cxtensions (Fig. 1). The membrane measures approximately . 065 nim in thickness.G