Miracle-dz/UniFAR-FTUs huggingface dataset:
Risk Factors, Health Care Resource Utilization, and Costs Associated with Nonadherence to Antiretrovirals in Medicaid-Insured Patients with HIV

BACKGROUND: Adherence to antiretrovirals (ARVs) is critical to achieving durable virologic suppression. OBJECTIVE: To investigate risk factors of poor adherence and the effect of suboptimal adherence on health care resource utilization (HCRU) and costs in Medicaid patients. METHODS: A retrospective longitudinal study was conducted using Medicaid data. Adults (aged ≥ 18 years) with human immunodeficiency virus (HIV)-1 initiating selected ARVs (index date) were identified. Adherence was measured using medication possession ratio (MPR) and proportion of days covered (PDC) at 6 and 12 months post-index. Risk factors of poor adherence (PDC < 80%) were assessed using a logistic regression. HCRU and costs were compared between suboptimal (80% ≤ PDC < 95%) and optimal (PDC ≥ 95%) adherence groups using Poisson and ordinary least square models, respectively. RESULTS: In total, 3,477 patients were identified. Using MPR, 1,282 (39.0%) of the evaluable patients had poor adherence; 667 (20.2%) had suboptimal adherence; and 1,342 (40.8%) had optimal adherence versus 1,342 (51.1%), 509 (19.0%), and 804 (30.0%), respectively, using PDC at 6 months. PDC at 12 months was even lower. Younger age (OR = 1.58; 95% CI = 1.18-2.11; P = 0.002), noncapitated coverage (OR = 1.40; 95% CI = 1.16-1.69; P < 0.001), dual Medicaid/Medicare coverage (OR = 5.98; 95% CI = 4.39-8.16; P < 0.001), no baseline ARV treatment (OR = 1.98; 95% CI = 1.62-2.41; P < 0.001), and baseline asymptomatic HIV (OR = 1.37; 95% CI = 1.13-1.68; P = 0.002) were associated with higher risk of poor adherence. Suboptimal adherence patients had higher total number of days spent in a hospital (incidence rate ratio [IRR] = 1.62; 95% CI = 1.13-2.19; P = 0.008), total number of long-term care admissions (IRR = 3.11; 95% CI = 1.26-7.39; P = 0.008), total medical costs (mean monthly cost difference = $339; 95% CI = $153-$536; P < 0.001), and inpatient costs (mean monthly cost difference = $259; 95% CI = $122-$418; P < 0.001) compared with patients with optimal adherence. CONCLUSIONS: Nonadherence to ARVs was observed in 60%-80% of Medicaid patients, depending on the adherence measure used, and was associated with incremental HCRU and costs. Age, insurance type and coverage, previous ARV treatment, and HIV symptoms were predictors of adherence. Treatment options that enhance adherence and prevent developing virologic failure with drug resistance should be considered for HIV patients.
3-D-Printed Quasi-Elliptical Evanescent Mode Filter Using Mixed Electromagnetic Coupling

This letter presents an innovative topology of evanescent mode filters with mixed electromagnetic coupling finalized to take full advantage of additive manufacturing techniques. A four-pole filter with two transmission zeroes was designed starting from a suitable equivalent circuit. The filter was built using a 3-D printer and measured. The good experimental results show the usefulness of the solution when in-line topologies are required.
Terrorism vulnerability: organizations’ ambiguous expectations and employees’ conflicting priorities

This study demonstrates how field employees’ perceived threat of terrorism (PTT) is magnified by the incompatibility between role demand (travel and work outdoors) and resources (terrorism-endangered environment). With a foundation in the conservation of resources perspective and transactional theory of stress, a theoretical framework was proposed to test the mediating effect of role ambiguity (RA) and role conflict (RC) in the relationship between PTT and emotional exhaustion (EE). An approach involving confirmatory factor analysis and the structural equation was used for analysis. Data from 432 pharmaceutical sales representatives indicate a significant positive relationship between PTT and EE, while RA and RC significantly mediated the relationship. The findings are potentially useful for employers in charge of field employees in high-risk regions by explaining how such groups can be provided with support to reduce their role stress and exhaustion, leading ultimately to increased satisfaction.
Deep Venous Thrombosis After Radical Pelvic Surgery

Deep venous thrombosis or DVT is a blood clot formation in one or more of the deep veins. The blood clot does not break down and therefore, it can become larger and occlude the blood flow within the affected vein. The most frequent sites are the leg veins (femoral and popliteal) and the deep pelvic veins. Rarely, the arm veins are affected (Paget-Schrotter disease). Pulmonary embolism (PE) is the most dangerous complication of DVT. PE occurs when the clot breaks into small pieces (emboli) and travel to the lung. The embolus may travel to other vital organs and cause life-threatening complications such as stroke or heart attack.
It's Complicated: The 2014–2015 U.S. Measles Outbreak and Parents’ Vaccination Beliefs, Confidence, and Intentions

While it seems intuitive that highly visible vaccine‐preventable disease outbreaks should impact perceptions of disease risk and facilitate vaccination, few empirical studies exist to confirm or dispel these beliefs. This study investigates the impact of the 2014–2015 Disneyland measles outbreak on parents’ vaccination attitudes and future vaccination intentions. The analysis relies on a pair of public opinion surveys of American parents with at least one child under the age of six (N = 1,000 across each survey). Controlling for basic demographics, we found higher levels of reported confidence in the safety and efficacy of childhood vaccinations in our follow‐up data collection. However, this confidence was also accompanied by elevated levels of concern toward childhood vaccines among American parents. We then examined how different subgroups in the population scored on these measures before and after the outbreak. We found that parents with high levels of interest in the topic of vaccines and a child who is not fully upto date with the recommended vaccination schedule reported more supportive attitudes toward vaccines. However, future intentions to follow the recommended vaccination schedule were not positively impacted by the outbreak. Possible explanations for these results and implications for vaccination outreach are discussed.
Steroidogenesis in ovarian‐like mesenchymal stroma of hepatic and pancreatic mucinous cystic neoplasms

Mucinous cystic neoplasms (MCNs) occur in the ovary, pancreas, and retroperitoneum but very rarely in the liver. Mucinous cystic neoplasms are known to harbor ovarian‐like mesenchymal stroma (OLS) expressing progesterone and estrogen receptors. In this study we evaluated steroidogenesis in OLS of 25 hepatic MCNs and 24 pancreatic MCNs.
A Single-Layer Dual-Frequency Shared-Aperture SIW Slot Antenna Array With a Small Frequency Ratio

This study provides a solution to achieve a single-layer dual-frequency shared-aperture slot antenna array with a small frequency ratio (FR) based on a substrate integrated waveguide (SIW) technology. Cavity resonator principles are applied to a distinctive SIW antenna array cavity to obtain dual operational frequencies on two separate ports while sharing the same radiation aperture. A 24-element SIW array prototype is designed and fabricated to validate the solution. The prototype has dual frequencies and a shared aperture with a small FR of 1.03 while maintaining a single-layer planar configuration and low cost. The two ports operate at 5.701 and 5.888 GHz. Reasonable parameters are obtained from the simulation and measurements, and there is a good agreement between the results.
Age-Related Developmental and Individual Differences in the Influence of Social and Non-social Distractors on Cognitive Performance

This study sought to examine age-related differences in the influences of social (neutral, emotional faces) and non-social/non-emotional (shapes) distractor stimuli in children, adolescents, and adults. To assess the degree to which distractor, or task-irrelevant, stimuli of varying social and emotional salience interfere with cognitive performance, children (N = 12; 8–12y), adolescents (N = 17; 13–17y), and adults (N = 17; 18–52y) completed the Emotional Identification and Dynamic Faces (EIDF) task. This task included three types of dynamically-changing distractors: (1) neutral-social (neutral face changing into another face); (2) emotional-social (face changing from 0% emotional to 100% emotional); and (3) non-social/non-emotional (shapes changing from small to large) to index the influence of task-irrelevant social and emotional information on cognition. Results yielded no age-related differences in accuracy but showed an age-related linear reduction in correct reaction times across distractor conditions. An age-related effect in interference was observed, such that children and adults showed slower response times on correct trials with socially-salient distractors; whereas adolescents exhibited faster responses on trials with distractors that included faces rather than shapes. A secondary study goal was to explore individual differences in cognitive interference. Results suggested that regardless of age, low trait anxiety and high effortful control were associated with interference to angry faces. Implications for developmental differences in affective processing, notably the importance of considering the contexts in which purportedly irrelevant social and emotional information might impair, vs. improve cognitive control, are discussed.
Few-Shot Segmentation Propagation with Guided Networks

Learning-based methods for visual segmentation have made progress on particular types of segmentation tasks, but are limited by the necessary supervision, the narrow definitions of fixed tasks, and the lack of control during inference for correcting errors. To remedy the rigidity and annotation burden of standard approaches, we address the problem of few-shot segmentation: given few image and few pixel supervision, segment any images accordingly. We propose guided networks, which extract a latent task representation from any amount of supervision, and optimize our architecture end-to-end for fast, accurate few-shot segmentation. Our method can switch tasks without further optimization and quickly update when given more guidance. We report the first results for segmentation from one pixel per concept and show real-time interactive video segmentation. Our unified approach propagates pixel annotations across space for interactive segmentation, across time for video segmentation, and across scenes for semantic segmentation. Our guided segmentor is state-of-the-art in accuracy for the amount of annotation and time. See this http URL for code, models, and more details.
Progressive Multifocal Leukoencephalopathy as a Presenting Manifestation of Acquired Immunodeficiency Syndrome in a Child Research

Progressive multifocal leukoencephalopathy is caused by JC virus and mainly affects human immunodeficiency virus infected patients. The disease is exceptionally rare in children. The diagnosis is based on magnetic resonance imaging and on the detection of JC virus DNA in the cerebrospinal fluid. This is a report of a 14 year old girl, not previously known to have human immunodeficiency virus, who was admitted to the hospital in a semicomatosed state after complaining of progressive neurologic symptoms for 4 months. Initially she complained of being tired and had an unsteady gait. This was followed by worsening myoclonic and generalized tonic-clonic convulsions. Brain magnetic resonance imaging revealed asymmetrical, diffuse subcortical white matter demyelination. Polymerase chain reaction test of the blood was positive for JC virus. Despite the initiation of antireteroviral therapy, the patient died in the intensive care unit 42 days after her admission. ISSN 2576-0564 Review Article Citation: Mamoun Al-Qaseer, Saroj Bala Grover, Mariam Al-Fadhli. Progressive Multifocal Leukoencephalopathy as a Presenting Manifestation of Acquired Immunodeficiency Syndrome in a Child. Int J Microbiol Infect Dis. 2017; 1(1): 1-3.
CAUGHT IN THE ACT: GAS AND STELLAR VELOCITY DISPERSIONS IN A FAST QUENCHING COMPACT STAR-FORMING GALAXY AT z ∼ 1.7

We present Keck I MOSFIRE spectroscopy in the Y and H bands of GDN-8231, a massive, compact, star-forming galaxy at a redshift of z ∼ 1.7. Its spectrum reveals both Hα and [N ii] emission lines and strong Balmer absorption lines. The Hα and Spitzer MIPS 24 μm fluxes are both weak, thus indicating a low star-formation rate of SFR ≲ 5 – 10 ? > M ⊙ ? > yr−1. This, added to a relatively young age of ∼700 Myr measured from the absorption lines, provides the first direct evidence for a distant galaxy being caught in the act of rapidly shutting down its star formation. Such quenching allows GDN-8231 to become a compact, quiescent galaxy, similar to three other galaxies in our sample, by z ∼ 1.5. Moreover, the color profile of GDN-8231 shows a bluer center, consistent with the predictions of recent simulations for an early phase of inside-out quenching. Its line-of-sight velocity dispersion for the gas, &sgr; LOS gas ? > = 127 ± 32 km s−1, is nearly 40% smaller than that of its stars, &sgr; LOS ⋆ ? > = 215 ± 35 km s−1. High-resolution hydro-simulations of galaxies explain such apparently colder gas kinematics of up to a factor of ∼1.5 with rotating disks being viewed at different inclinations and/or centrally concentrated star-forming regions. A clear prediction is that their compact, quiescent descendants preserve some remnant rotation from their star-forming progenitors.
The effects of using an active workstation on executive function in Chinese college students

This study aimed to examine the effects of active workstation use on the executive function by measuring the three components of executive function (Inhibition, Updating, and Shifting) during sitting, standing, and walking at an active workstation with different speeds. Twenty-four college students completed a cognitive test battery while sitting, standing, walking on an active workstation with a self-selected speed (mean = 2.3 km/h) and a faster speed (mean = 3.5 km/h). The three components of executive function (Inhibition, Updating, and Shifting) were assessed by Stroop task, N-back task, More-odd shifting task, respectively. Performance of each task was determined by the response time and accuracy. Repeated measures ANOVAs were conducted with workstation condition and trial type as within-subjects factors. There were no significant main effects for workstation condition and no interaction between workstation condition × trial type in Stroop task and More-odd shifting task. There was a significant main effect for workstation condition (F (3, 69) = 4.029, p = 0.011) and interaction effect between workstation condition × trial type (F (6, 138) = 9.371, p < 0.001) in N-back task. Decomposition of the interaction showed that accuracy of 2-back task in self-paced walking was significantly lower than that in sitting condition (p = 0.017) and in standing condition (p < .001). But there was no difference in accuracy of 2-back task between self-paced walking condition and faster walking condition (p = 0.517). Our results suggest that using an active workstation may have a selective impact on three components of executive function, in which the Updating may be impaired to a certain extent while the Inhibition and Shifting remain unaffected.
Low-Profile Dual-Polarization Frequency-Selective Rasorbers Based on Simple-Structure Lossy Cross-Frame Elements

The low-profile dual-polarization frequency-selective rasorbers with very simple structures are investigated. Based on an equivalent circuit model, the operating principle and design method are first studied. One rasorber using lossy cross-frame elements and double-square loops is then proposed, which exhibits two absorption bands at the two sides of one passband. Moreover, the rasorbers with reduced cell size are further developed to stabilize the angular response. Under normal incidence, an insertion loss of about 0.26 dB is obtained at 4.25 GHz, the fractional bandwidth for reflection less than −10 dB is over 100%, and the thickness is around ${\text{0.1}}\,\lambda _{L}$. For demonstration, the rasorber prototypes are fabricated and measured, while reasonable agreements are observed accordingly.
The effect of shear flow on the rotational diffusion of a single axisymmetric particle

Understanding the orientation dynamics of anisotropic colloidal particles is important for suspension rheology and particle self-assembly. However, even for the simplest case of dilute suspensions in shear flow, the orientation dynamics of non-spherical Brownian particles are poorly understood. Here we analytically calculate the time-dependent orientation distributions for non-spherical axisymmetric particles confined to rotate in the flow–gradient plane, in the limit of small but non-zero Brownian diffusivity. For continuous shear, despite the complicated dynamics arising from the particle rotations, we find a coordinate change that maps the orientation dynamics to a diffusion equation with a remarkably simple ratio of the enhanced rotary diffusivity to the zero shear diffusion: $D_{eff}^{r}/D_{0}^{r}=(3/8)(p-1/p)^{2}+1$ , where $p$ is the particle aspect ratio. For oscillatory shear, the enhanced diffusion becomes orientation dependent and drastically alters the long-time orientation distributions. We describe a general method for solving the time-dependent oscillatory shear distributions and finding the effective diffusion constant. As an illustration, we use this method to solve for the diffusion and distributions in the case of triangle-wave oscillatory shear and find that they depend strongly on the strain amplitude and particle aspect ratio. These results provide new insight into the time-dependent rheology of suspensions of anisotropic particles. For continuous shear, we find two distinct diffusive time scales in the rheology that scale separately with aspect ratio $p$ , as $1/D_{0}^{r}p^{4}$ and as $1/D_{0}^{r}p^{2}$ for $p\gg 1$ . For oscillatory shear flows, the intrinsic viscosity oscillates with the strain amplitude. Finally, we show the relevance of our results to real suspensions in which particles can rotate freely. Collectively, the interplay between shear-induced rotations and diffusion has rich structure and strong effects: for a particle with aspect ratio 10, the oscillatory shear intrinsic viscosity varies by a factor of ${\approx}2$ and the rotational diffusion by a factor of ${\approx}40$ .
Projection-Resolved OCT Angiography of Microvascular Changes in Paracentral Acute Middle Maculopathy and Acute Macular Neuroretinopathy

Purpose To identify the microvascular changes associated with paracentral acute middle maculopathy (PAMM) and acute macular neuroretinopathy (AMN) and to improve our understanding of the relevant involvement of the three retinal capillary plexuses using projection-resolved optical coherence tomography angiography (PR-OCTA). Methods This was a retrospective study of 18 eyes with AMN or PAMM imaged with OCTA. We used cross-sectional PR-OCTA to localize reduced flow signal to the superficial (SCP), middle (MCP), or deep capillary plexus (DCP) or choriocapillaris that corresponded to inner retinal PAMM or outer retinal AMN lesions on OCT. Results Five eyes with AMN showed outer retinal disruption on OCT associated with reduced DCP flow signal. All three eyes with AMN and follow-up had recovery of DCP flow. Thirteen eyes with PAMM showed middle retinal disruption on OCT associated with reduced flow signal in both the MCP and DCP. Of these, five also had reduced flow signal in the SCP. All 10 eyes with PAMM and follow-up showed variable recovery of flow signal in one or more plexuses. PAMM reperfusion was primarily arterial in nature. Three eyes with PAMM and no evidence of MCP reperfusion experienced severe thinning of the inner nuclear layer (INL), while seven eyes with robust MCP flow signal recovery showed relative preservation of INL thickness. Conclusions Using PR-OCTA, we found that AMN was associated with reduced DCP flow signal, while PAMM was associated with reduced MCP and DCP flow signal and occasionally the SCP. The MCP appears to be important in sustaining INL thickness in these eyes.
The OBF Database: A Large Face Video Database for Remote Physiological Signal Measurement and Atrial Fibrillation Detection

Physiological signals, including heart rate (HR), heart rate variability (HRV), and respiratory frequency (RF) are important indicators of our health, which are usually measured in clinical examinations. Traditional physiological signal measurement often involves contact sensors, which may be inconvenient or cause discomfort in long-term monitoring sessions. Recently, there were studies exploring remote HR measurement from facial videos, and several methods have been proposed. However, previous methods cannot be fairly compared, since they mostly used private, self-collected small datasets as there has been no public benchmark database for the evaluation. Besides, we haven't found any study that validates such methods for clinical applications yet, e.g., diagnosing cardiac arrhythmias/disease, which could be one major goal of this technology. In this paper, we introduce the Oulu Bio-Face (OBF) database as a benchmark set to fill in the blank. The OBF database includes large number of facial videos with simultaneously recorded reference physiological signals. The data were recorded both from healthy subjects and from patients with atrial fibrillation (AF), which is the most common sustained and widespread cardiac arrhythmia encountered in clinical practice. Accuracy of HR, HRV and RF measured from OBF videos are provided as the baseline results for future evaluation. We also demonstrated that the video-extracted HRV features can achieve promising performance for AF detection, which has never been studied before. From a wider outlook, the remote technology may lead to convenient self-examination in mobile condition for earlier diagnosis of the arrhythmia.
Real-Time Intraocular Pressure Measurements in the Vitreous Chamber of Rabbit Eyes During Small Incision Lenticule Extraction (SMILE)

ABSTRACT Purpose: To investigate real-time intraocular pressure (IOP) during small incision lenticule extraction (SMILE) in rabbit eyes for myopia correction. Methods: During SMILE, real-time IOP was measured in the vitreous cavity of rabbit eyes with an optic fiber pressure sensor (OFPS). Two groups (n = 6 for each) underwent surgery, one group for a −2.00 diopter (D) refractive spherical correction and the other for a −6.00 D correction. Results: During surgery, the IOP increased once the glass contact attached to the cornea (Pre-suction), and peaked 83.94 mmHg (SD ± 23.87 mmHg) for the −2.00 D group and 89.17 mmHg (SD ± 22.66 mmHg) for the −6.00 D group, both average values were less than 110 mmHg when suction was initiated to fix the glass contact onto the cornea (Suction on). It then fell to 74.81 mmHg (SD ± 20.64 mmHg) and 76.94 mmHg (SD ± 27.43 mmHg), respectively, and remained stable during lenticule creation (Cutting). After suction stopped (Suction off), IOP fell steeply. During lenticule separation/extraction, the change in IOP was 32.26 mmHg (SD ± 2.91 mmHg). Notably, the average duration of elevated IOP during the surgery was 166.05 s (no longer than 3 min). Conclusions: The IOP fluctuations in the vitreous cavity using an OFPS in a rabbit model during SMILE showed that real-time IOP significantly was increased during Pre-suction, Suction on, Cutting, Suction off, and lenticule separation/extraction compared to baseline IOP, although, peaked at Suction on. Neither the degree of myopic correction nor central corneal thickness significantly affected these changes in IOP.