Miracle-dz/UniFAR-FTUs huggingface dataset:
ACTIVE DISK BUILDING IN A LOCAL H i-MASSIVE LIRG: THE SYNERGY BETWEEN GAS, DUST, AND STAR FORMATION

HIZOA J0836-43 is the most H i-massive (MH i = 7.5 × 1010 M☉) galaxy detected in the HIPASS volume (δ = −90° to + 25°, v<12,700 km s−1) and lies optically hidden behind the Milky Way. Markedly different from other extreme H i disks in the local universe, it is a luminous infrared galaxy (LIRG) with an actively star-forming disk (>50 kpc), central to its ∼130 kpc gas disk, with a total star formation rate (SFR) of ∼20.5 M☉ yr-1. Spitzer spectroscopy reveals an unusual combination of powerful polycyclic aromatic hydrocarbon (PAH) emission coupled to a relatively weak warm dust continuum, suggesting photodissociation-region-dominated emission. Compared to a typical LIRG with similar total infrared luminosity (LTIR = 1011 L☉), the PAHs in HIZOA J0836-43 are more than twice as strong, whereas the warm dust continuum (λ>20 μm) is best fit by a star-forming galaxy with LTIR = 1010 L☉. Mopra CO observations suggest an extended molecular gas component (H2 + He>3.7 × 109 M☉) and a lower limit of ∼64% for the gas-mass fraction; this is above average compared to local disk systems, but similar to that of z ∼ 1.5 BzK galaxies (∼57%). However, the star formation efficiency (SFE = LIR/L′CO) for HIZOA J0836-43 of 140 L☉ (K km s−1 pc2)−1 is similar to that of local spirals and other disk galaxies at high redshift, in strong contrast to the increased SFE seen in merging and strongly interacting systems. HIZOA J0836-43 is actively forming stars and building a massive stellar disk. Its evolutionary phase of star formation (Mstellar, SFR, and gas fraction) compared to more distant systems suggests that it would be considered typical at redshift z ∼ 1. This galaxy provides a rare opportunity in the nearby universe for studying (at z ∼ 0.036) how disks were building and galaxies evolving at z ∼ 1, when similarly large gas fractions were likely more common.
Effect of omp10 or omp19 Deletion on Brucella abortus Outer Membrane Properties and Virulence in Mice

ABSTRACT The distinctive properties of Brucella outer membrane have been considered to be critical for Brucella sp. virulence. Among the outer membrane molecules possibly related to these properties, Omp10 and Omp19 are immunoreactive outer membrane lipoproteins. Moreover, these proteins of Brucella could constitute a new family of outer membrane proteins specifically encountered in the family Rhizobiaceae. We evaluated the impact of omp10 or omp19 deletion on Brucella abortus outer membrane properties and virulence in mice. The omp10 mutant was dramatically attenuated for survival in mice and was defective for growth in minimal medium but was not impaired in intracellular growth in vitro, nor does it display clear modification of the outer membrane properties. Significantly fewer brucellae were recovered from the spleens of mice infected with the omp19 mutant than from those of mice infected with the parent strain at 4 and 8 weeks postinfection. The omp19 mutant exhibited an increase in sensitivity to the polycation polymyxin B and to sodium deoxycholate. These results indicate that inactivation of the omp19 gene alters the outer membrane properties of B. abortus.
Ankle injuries

Ice: Use ice (in a plastic bag, ice bag or cold pack) for 15 to 20 minutes every 1 to 2 hours during the first 48 hours after your injury. You should place a thin layer of fabric, such as a pillowcase, between the ice bag and your skin. After 48 hours, continue to ice 2 to 4 times a day for pain and swelling. Compression: An elastic bandage helps to keep the swelling down. Keep it on the injured area as long as there is swelling but remove it at night.
Interrelationships between the content of oxidative markers, antioxidative status, and somatic cell count in cow’s milk

Bovine mastitis is a major disease affecting dairy cattle worldwide. The milk collected from cows with different type of inflammation, including mastitis, is characterized by an increased number of somatic cells (SCC), especially polymorphonuclear cells (PMN). It was proved that the antibacterial activity of PMN generates reactive oxygen species and nitric oxide-derived metabolites. The accumulation of the reactive species correlating with a decrease in the antioxidant activity specific for milk can lead to oxidative and nitrosative stress. The aim of this study was to evaluate the antioxidant/oxidant status in normal cow’s milk and in subclinical mastitis milk using three parameters: total antioxidant status (TAS); levels of malondialdehyde (MDA) – a degradation product of lipid peroxidation; and levels of proteins oxidation expressed as carbonylated proteins analyzed in the reaction with dinitrophenilhydrazine (DNPH). Subclinical mastitis was diagnosed using an electrical conductivity method and by determining the number of SCC in milk. Comparative analysis of TAS in normal and mastitis milk revealed extremely significant differences (P = 0.0005), the average of this parameter was lower for mastitis milk samples. The results describing the antioxidant status were correlated with those on lipid and protein oxidative degradation. The average level of MDA in mastitis milk was higher compared with normal milk, the mean difference was 40.69 nmol/ml. A similar variation was observed for DNPH, the mean difference was 191.24 μmol/ml. The levels of SCC, MDA, and DNPH were significantly higher in subclinical mastitis milk compared to milk from healthy cows due to the occurrence of oxidative stress state in subclinically inflamed mammary gland.
THE MORPHOLOGY OF THE EJECTA IN SUPERNOVA 1987A: A STUDY OVER TIME AND WAVELENGTH

We present a study of the morphology of the ejecta in Supernova 1987A based on images and spectra from the Hubble Space Telescope (HST) as well as integral field spectroscopy from VLT/SINFONI. The HST observations were obtained between 1994 and 2011 and primarily probe the outer H-rich zones of the ejecta. The SINFONI observations were obtained in 2005 and 2011 and instead probe the [Si i]+[Fe ii] emission from the inner regions. We find a strong temporal evolution of the morphology in the HST images, from a roughly elliptical shape before ∼5000 days, to a more irregular, edge-brightened morphology with a “hole” in the middle thereafter. This transition is a natural consequence of the change in the dominant energy source powering the ejecta, from radioactive decay before ∼5000 days to X-ray input from the circumstellar interaction thereafter. The [Si i]+[Fe ii] images display a more uniform morphology, which may be due to a remaining significant contribution from radioactivity in the inner ejecta and the higher abundance of these elements in the core. Both the Hα and the [Si i]+[Fe ii] line profiles show that the ejecta are distributed fairly close to the plane of the inner circumstellar ring, which is assumed to define the rotational axis of the progenitor star. The Hα emission extends to higher velocities than [Si i]+[Fe ii], as expected from theoretical models. There is no clear symmetry axis for all the emission. Instead, we find that the emission is concentrated to clumps and that the emission is distributed somewhat closer to the ring in the north than in the south. This north–south asymmetry may be partially explained by dust absorption. We compare our results with explosion models and find some qualitative agreement, but note that the observations show a higher degree of large-scale asymmetry.
STEREOTACTIC RADIOSURGERY FOR VESTIBULAR SCHWANNOMAS IN PATIENTS WITH NEUROFIBROMATOSIS TYPE 2: AN ANALYSIS OF TUMOR CONTROL, COMPLICATIONS, AND HEARING PRESERVATION RATES

OBJECTIVEVestibular schwannomas present significant management challenges in patients with neurofibromatosis Type 2 (NF2). We evaluated the results of gamma knife radiosurgery for the management of these tumors, focusing on tumor response, hearing preservation, and other factors affecting outcomes. METHODSStereotactic radiosurgery was performed to manage 74 schwannomas in 62 patients. Ipsilateral serviceable hearing was present in 35% of tumors before the procedure. The mean tumor volume was 5.7 cm3. The mean margin and maximum dose used were 14 and 27.5 Gy, respectively. Cox regression analyses were performed to identify factors affecting outcomes. RESULTSThe median follow-up period was 53 months, and two patients were lost to follow-up. Actuarial local control rates at were 85, 81, and 81% at 5, 10, and 15 years, respectively. Tumor volume was significant as a predictor of local control. Since 1992, using current radiosurgery techniques (magnetic resonance imaging scan targeting and reduced margin dose to 14 Gy or less), the actuarial serviceable hearing preservation rate is 73% at 1 year, 59% at 2 years, and 48% at 5 years after radiosurgery. Facial neuropathy occurred in 8% of tumors, trigeminal neuropathy occurred in 4%, and vestibular dysfunction occurred in 4%. Radiation dose and tumor volume were predictive of development of new deficits. No radiosurgery-associated secondary tumors or atypical or malignant changes were noted. CONCLUSIONStereotactic radiosurgery is a safe and effective management modality for neurofibromatosis Type 2 vestibular schwannomas. Although results do not seem to be as good as for patients with sporadic unilateral tumors, gamma knife radiosurgery results seem favorable and indicate that radiosurgery should be strongly considered for primary tumor management in selected patients.
Marked differences in the skin tumor-initiating activities of the optical enantiomers of the diastereomeric benzo(a)pyrene 7,8-diol-9,10-epoxides.

Abstract The abilities of the optically pure (+)- and (-)-enantiomers of the diastereomeric 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo( a )pyrenes derived from the enantiomeric trans -7,8-dihydrodiols to initiate skin tumors in mice were determined with a two-stage system of tumorigenesis. As a tumor initiator, (+)-7β,8α-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo( a )pyrene 2 was approximately 60% as active as was benzo( a )pyrene, whereas (-)-7α,8β-dihydroxy-9β,10β-epoxy-7,8,9,10-tetrahydrobenzo( a )pyrene 2 was about 2% as active as was benzo( a )pyrene. The racemic mixture of the above diol-epoxide, in which the 9,10-epoxide is trans to the 7-hydroxyl group, was 25% as active as was benzo( a )pyrene as a tumor initiator. (-)-7β,8α-Dihydroxy-9β,10β-epoxy-7,8,9,10-tetrahydrobenzo( a )pyrene 1 and (+)-7α,8β-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo( a )pyrene 1, in which the 9,10-epoxide is cis to the 7-hydroxyl group, were found to have little or no tumorigenic activity. The tumor-initiating ability of (+)-7β,8α-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo( a )pyrene 2 was found to be greater when given daily for 6 days at a dose of 34 nmol/day than when given once at a 200-nmol dose level. Similar fractionated doses of benzo( a )pyrene or (-)-7α,8β-dihydroxy-9β,10β-epoxy7,8,9,10-tetrahydrobenzo( a )pyrene 2 did not increase their skin tumor-initiating activity. The data suggest that (+)-7β,8α-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo( a )pyrene is an ultimate carcinogenic form of benzo( a )pyrene.
New Conditions That Guarantee Uniform Asymptotically Stable and Absolute Stability of Singularly Perturbed Systems of Certain Class of Nonlinear Differential Equations

The objectives of this paper is to investigate singularly perturbed system of the fourth order differential equations of the type, to establish the necessary and sufficient new conditions that guarantee, uniform asymptotically stable, and absolute stability of the system. The Liapunov’s functions were the mathematical model used to establish the main results of this study. The study was motivated by some authors in the literature, Grujic LJ.T, and Hoppensteadt, F. , and the results obtained in this study improves upon their results to the case where more than two arguments was established.
Copeptin as a stress marker prior and after a written examination – the CoEXAM study

Abstract The stress hormone copeptin, which is co-secreted with arginine vasopressin, increases in seriously ill patients and can predict outcome in several organic diseases. Information about the influence of psychological stress on copeptin levels is lacking, but is important for interpretation of copeptin levels in the clinical setting. The aim of this study was to evaluate the influence of psychological stress on copeptin levels. We measured copeptin levels in 25 healthy medical students before and after a written examination. The primary endpoint was change in copeptin levels from immediately prior to examination compared with after the examination. Median copeptin levels prior to the examination were significantly higher than those after its conclusion. Similar results were found for serum cortisol and salivary cortisol. Serum cortisol prior to examination was significantly higher in students with a superior examination result, compared to those with a lower score. In conclusion, psychological stress leads to a subtle increase in copeptin level and might therefore be taken into account as a confounding factor in disorders with small diagnostic copeptin range. Higher cortisol levels, but not copeptin, correlated with a better academic performance in this cohort of students.
Bamford-Stevens reaction assisted synthesis of styrene C-glycosides

Abstract Modification of carbohydrates and their analogs is hindered due to multi-step synthetic methodologies involving selective protection and deprotection of multiple hydroxyl groups present in the molecule. A highly efficient route for the synthesis of 1-phenyl-2-(β-D-glycopyranosyl)ethenes has been developed from native sugars, which neither requires protection/deprotection of the hydroxyl groups nor use of any metal/metal ions. The key step of the developed methodology is the use of Bamford-Stevens reaction which led to the formation of the desired compounds in moderate to high yields in three steps only. Graphical Abstract
Gametogenesis in the major group of vascular plants : the angiosperms

Higher plants have evolved to be one of the predominant life forms on this planet. A great deal of this evolutionary success relies in a very short gametophytic phase which underlies the sexual reproduction cycle. Sexual plant reproduction takes place in special organs of the flower. In most species the processes of gametogenesis, pollination, syngamy and embryogenesis are sequentially coordinated to give rise to a functional seed in a matter of few weeks. Any of these processes is so intricately complex and precisely regulated that it becomes no wonder that each involves more specific genes and cellular processes than any other function in the plant life cycle. While variability generation the evolutionary output of the sexual cycle is the same as in any other Kingdom, plants do it using a completely original set of mechanisms, many of which are not yet comprehended. In this paper, we cover the fundamental features of male and female gametogenesis. While the physiological and cellular bases of these processes have been continuously described since the early nineteen century, recent usage of Arabidopsis and other species as central models has brought about a great deal of specific information regarding their genetic regulation. Transcriptomics has recently enlarged the repertoire and pollen became the first gametophyte to have a fully described transcriptome in plants. We thus place special emphasis on the way this newly accumulated genetic and transcriptional information impacts our current understanding of the mechanisms of gametogenesis.
Effects of washing, peeling, storage, and fermentation on residue contents of carbaryl and mancozeb in cucumbers grown in greenhouses

Cucumbers grown in two different greenhouses were exposed to mancozeb and carbaryl at different times. The effects of 10-day preharvest period, water and detergent washing, peeling, predetermined storage period at 4°C (refrigeration), and fermentation on the reduction of residue levels in the plant tissues were investigated. Mancozeb and carbaryl residues in cucumbers were determined by gas chromatography–electron capture detection. Results showed that residue levels in samples, which were collected after 10 days following the pesticide application, were significantly lower than the samples collected after 2 h subsequent to the pesticide application. The culinary applications were effective in reducing the residue levels of the pesticides in cucumbers. As a result, non-fermentative pickling in sodium chloride and acetic acid was the most effective way to reduce the mancozeb and carbaryl residues of the cucumbers.
Chlamydophila psittaci Zoonotic Risk Assessment in a Chicken and Turkey Slaughterhouse

ABSTRACT Chlamydophila psittaci causes respiratory disease in poultry and can be transmitted to humans. We conducted a C. psittaci zoonotic risk assessment study of a chicken and turkey slaughterhouse. Eighty-five percent of the slaughtered chicken flocks tested positive by PCR and culture. Genotype D was discovered. Fifty-seven percent of the slaughtered turkey flocks tested positive by PCR and culture. Genotype D was present. For the chicken slaughterhouse employees, 7.5% and 6% tested positive for C. psittaci by PCR and culture, respectively. In the turkey slaughterhouse, 87% and 61% of the employees tested positive by PCR and culture, respectively. All genotyped human samples contained genotype D. Using stationary bioaerosol monitoring by means of an MAS-100 ecosampler and ChlamyTrap collection medium, chlamydial DNA, and viable organisms were detected in both the chicken and turkey slaughterhouses. Positive air samples were most frequently found in the animal reception area and evisceration room. Zoonotic transmissions were very common, especially from processed turkeys. Accurate diagnostic monitoring and reporting of C. psittaci infections should be promoted in poultry workers.
NMDA receptor antagonist MK-801 reduces neuronal damage and preserves learning and memory in a rat model of traumatic brain injury

Objective NMDA receptor channel plays an important role in the pathophysiological process of traumatic brain injury (TBI). The present study aims to study the pathological mechanism of TBI and the impairment of learning and memory after TBI, and to investigate the mechanism of the protective effect of NMDA receptor antagonist MK-801 on learning and memory disorder after TBI. Methods Forty Sprague-Dawley rats (weighing approximately 200 g) were randomized into 5 groups (n = 8 in each group): control group, model group, low-dose group (MK-801 0.5 mg/kg), middle-dose group (MK-801 2 mg/kg), and high-dose group (MK-801 10 mg/kg). TBI model was established using a weight-drop head injury mode. After 2-month drug treatment, learning and memory ability was evaluated by using Morris water maze test. Then the animals were sacrificed, and brain tissues were taken out for morphological and immunohistochemical assays. Results The ability of learning and memory was significantly impaired in the TBI model animals. Besides, the neuronal caspase-3 expression, neuronal nitric oxide synthase (nNOS)-positive neurons and OX-42-positive microglia were all increased in TBI animals. Meanwhile, the number of neuron synapses was decreased, and vacuoles degeneration could be observed in mitochondria. After MK-801 treatment at 3 different dosages, the ability of learning and memory was markedly improved, as compared to that of the TBI model animals. Moreover, neuronal caspase-3 expression, OX-42-positive microglia and nNOS-positive neurons were all significantly decreased. Meanwhile, the mitochondria degeneration was greatly inhibited. Conclusion MK-801 could significantly inhibit the degeneration and apoptosis of neurons in damaged brain areas. It could also inhibit TBI-induced increase in nNOS-positive neurons and OX-42-positive microglia. Impairment in learning and memory in TBI animals could be repaired by treatment with MK-801.
Eco-physiological performance may contribute to differential success of two forms of an invasive vine, Dolichandra unguis-cati, in Australia

Invasive plant species are hypothesized as being more efficient at resource acquisition and use, resulting in faster growth than co-occurring non-invasive plant species. Nonetheless, some findings suggest that trait differences between invasive and non-invasive species are context dependent. In this study, two forms of an invasive vine species,Dolichandraunguis-cati, were used to test the context-dependent hypothesis.Dolichandraunguis-catiis a weed of national significance in Australia with two different forms: the ‘long pod’ (LP) and ‘short pod’ (SP). The two forms have different levels of distribution on the eastern Seaboard of the continent, with the SP form occurring extensively in both States of Queensland and New South Wales while the LP form is found only in isolated sites in South-East Queensland. This study examines whether differences in eco-physiological performance could be responsible for differential success of the two forms. A partially factorial experiment was set up in controlled conditions where potted plants of both forms were grown under two levels of light, water and nutrient resources (high and low) for 15 months. We measured several traits that are known to correlate with plant performance and resource use efficiency (RUE). The SP form exhibited higher values of carbon assimilation, RUE, number of subterranean tubers and leaf nitrogen than the LP form. However, the LP form produced greater biomass than the SP form, with the difference driven mainly by high resource conditions. The LP form displayed significantly higher phenotypic integration (number of traits significantly correlated) than the SP form in response to all treatments while the SP form exhibited higher phenotypic integration than the LP form in response to high resource conditions only. The SP form displayed traits that are well suited for successful colonization, possibly explaining its increased success in Australia, while the LP form possessed traits of opportunistic plants. Overall, we find that the two forms of the weedy vine deploy different carbon economies in response to resource conditions, which is evidence of the context-dependent trait hypothesis.
Creating and Controlling the Ethical Framework of Mediation

The mediator can play an active role in creating the ethical framework in the conflict mediation. A pyramidal hierarchy of ethics principles in mediation is proposed: mediator’s ethics/legality and morality of the negotiation subject/ethics in the communication between negotiators/ethics of the procedures, techniques and tactics of negotiation. Exercising a triple role (personal example of ethics, generator of negotiation ethics rules, guarantor of minimal ethical framework), the mediators can become the creators of the mediation ethical framework. This ethical framework created by the mediator can be controlled through techniques systematized in a methodology for neutralizing unethical impulses of the negotiators involved in mediation. The proposed method selects a range of possible interventions depending on the orientation of negotiators identified by the mediator - to objective or to relationship. The mediator can use these techniques without exceeding its role of neutral and impartial person. The pro-active attitude of the mediator in the mediation ethical framework construction is identified as the key to reach equitable agreements and the future commitment of the parties.