Miracle-dz/UniFAR-FTUs huggingface dataset:
Acceptability of Novel Small-Quantity Lipid-Based Nutrient Supplements for Complementary Feeding in a Peri-Urban South African Community

Background: Small-quantity lipid-based nutritional supplements (SQ-LNS) may potentially be used for home fortification in poor settings, where low nutrient-dense complementary foods are commonly used for infant feeding. However, they need to be acceptable to succeed. Objective: This study assessed the acceptability of 2 novel, SQ-LNS (A and B) for supplementing complementary foods among infants aged 6 to 12 months in a peri-urban South African community. Methods: Both supplements were soy-based pastes and contained micronutrients and essential fatty acids. In addition, supplement B contained docosahexaenoic acid, arachidonic acid, phytase and l-lysine. Mother–infant pairs were enrolled in a 2-part trial. Part 1 (n = 16) was a test-feeding trial with a crossover randomized design, and a 5-point hedonic scale was used for sensory evaluation (disagree = 1, agree = 5). Part 2 (n = 38) was a 2-week, home-use trial followed by focus group discussions. Results: In part 1, more than 70% of mothers reported a score ≥4 on sensory attributes for both SQ-LNSs indicating that both supplements were well perceived. In part 2, the mean reported consumption over the 2-week period was 65.3% ± 34.2% and 62.0% ± 31.3% of the 20 g daily portion for supplements A and B, respectively. Focus group discussions confirmed a positive attitude toward the supplements in the study population. Conclusion: This study showed acceptance of both SQ-LNSs in terms of sensory characteristics as well as in terms of practicality for home use.
UHF Propagation in the Magnetic Resonance Bore

The magnetic resonance (MR) bore's structure, loading parameters, and material makeup greatly influence the ability of a frequency-specific signal to propagate. The relative path loss behavior of the MR bore has been determined experimentally at ultra-high frequencies (UHFs). An experiment is conducted to determine signal attenuation when the bore is empty (air-filled) or dielectrically loaded (patient-filled). This information is especially important to the wireless network designer who is implementing an in-bore physiological monitoring network. Experimental results show that the MR bore exhibits impressive path loss performance at 434 MHz, with greatest signal strength arriving at the receiver when the bore is dielectrically loaded.
Estimated Drainage of Carbon from the Tricarboxylic Acid Cycle for Protein Synthesis in Suspension Cultures of Paul's Scarlet Rose Cells.

The amount of carbon (mumoles of carbon atoms) drained from the tricarboxylic acid cycle for protein synthesis was compared with mumoles of CO(2) released from the cycle at 2-day intervals during the growth of suspension cultures of Paul's Scarlet rose. We concluded that during the period of most rapid protein synthesis (day 0-4) one-sixth as much carbon was drained from the tricarboxylic acid cycle for protein synthesis as was released as CO(2). By day 8, one-thirtieth of the amount of carbon released as CO(2) was incorporated into protein. Net protein synthesis stopped on day 8, but the evolution of CO(2)/culture continued at its maximum rate until day 10.Similar ratios were calculated based on the recovery of (14)C in protein versus CO(2) following a 3-hr provision of labeled substrates to 3-day-old cells (age of maximum protein synthesis). Provision of acetate-1-(14)C and acetate-2-(14)C indicated from one-eighth to an equal amount of carbon was incorporated into protein as was released as CO(2). When (14)C-labeled intermediates of the tricarboxylic acid cycle were provided, the ratio of (14)C incorporated into protein versus that evolved in CO(2) ranged from 1/0.9 to 1/4.9. Following a critical analysis of the methods used, it was concluded that during periods of rapid protein synthesis, a conservative estimate of the amount of carbon drained from the tricarboxylic acid cycle for protein synthesis was one-fourth of the amount evolved as CO(2) from the cycle.
The Heart Rate Response to Exercise Is Blunted in Patients with Sleep-Related Breathing Disorder

Background: This study addressed the hypothesis that cardiovascular reactivity during graded bicycle exercise is influenced by a coexisting sleep-related breathing disorder (SRBD). Methods: Blood pressure and heart rate were assessed at rest and during graded exercise (110 W and maximal load) in 1,149 patients of a Sleep Disorders Center. The degree of SRBD, and potential confounders, including blood gases and pulmonary function, were determined. Results: Maximal exercise capacity tended to decrease with SRBD activity (p = 0.07). The heart rate reactivity was blunted and reduced by –0.07 and –0.09 beats/min for every SRBD unit at 110 W (p < 0.001) and at maximal load (p < 0.001), respectively. Systolic and diastolic blood pressure reactivity at maximal load were positively associated with SRBD severity. These associations were independent of possible confounders. Conclusion: SRBD is associated with reduced physical working capacity and a modified hemodynamic response to exercise.
Predictors of outcomes following catheter‐based therapy for acute stroke

Timely reperfusion directly impacts favorable neurologic outcomes in acute ischemic stroke (AIS) patients. Most strokes present outside the 3–4.5 h window for intravenous thrombolysis (IV‐tPA). Catheter‐based therapy (CBT) is commonly used in patients not eligible for timely IV‐tPa, but variables that predict good neurologic outcomes are poorly understood.
Present Bias and Financial Behavior

Present bias is an important term in behavioral finance that is derived from the concept of self-control. Empirical research finds that present bias is associated with undesirable spending, borrowing, and saving behavior. Unlike previous research that focuses on one domain of financial behavior, the purpose of this study is to examine associations between present bias and a set of financial behaviors in various domains such as spending, borrowing, saving, and money management. With data from a national urban sample in China, results show that some behavioral patterns are consistent with theoretical predictions that present biased consumers are more likely to spend now and less likely to save. The findings have implications for further research of present bias to better understand this important concept and for financial advisors to better serve their clients.
Characterization of the transition technique from enteral tube feeding to breastfeeding in preterm newborns.

PURPOSE To verify the corrected gestational age when oral feeding (breast half full) and exclusive breastfeeding were initiated in preterm newborns submitted to the transition technique from enteral feeding directly to breastfeeding, and time spent (in days) under speech-language pathology intervention until discharge. METHODS Study participants were 35 preterm infants (PTI) divided into two groups. Group 1 (G1) was composed by 22 PTI who did not present any important medical complications during hospitalization, and Group 2 (G2) comprised 13 PTI with a history of major medical complications. The following data were recorded: gestational age at birth, birth weight, weight and corrected gestational age during speech-language pathology evaluation, corrected gestational age when started oral feeding, number of days stimulated through the non-nutritive sucking (NNS) technique, corrected gestational age when oral feeding started and when they were discharged from speech-language pathology intervention, and total number of days under speech-language pathology intervention. RESULTS No differences were found between the groups (G1 and G2) for any of the analyzed parameters. In general, oral feeding started with an average of 36 weeks corrected gestational age. Exclusive oral feeding occurred with an average of 36.6 weeks corrected gestational age. In average, speech-language pathology intervention lasted 12.3 days, and the NNS technique in "gloved finger" or "empty breast" lasted an average of 4.54 days. CONCLUSION The technique allowed the PTI to be discharged in exclusive breastfeeding at a corrected gestational age corresponding to that of healthy term newborns.
Acute Effect of Different Stretching Methods on Illinois Agility Test in Soccer Players

Amiri-Khorasani, M, Sahebozamani, M, Tabrizi, KG, and Yusof, AB. Acute effect of different stretching methods on Illinois agility test in soccer players. J Strength Cond Res 24(10): 2698-2704, 2010-The purpose of this study was to examine the effects of static, dynamic, and the combination of static and dynamic stretching within a pre-exercise warm-up on the Illinois agility test (IAT) in soccer players. Nineteen professional soccer players (age = 22.5 ± 2.5 years, height = 1.79 ± 0.003 m, body mass = 74.8 ± 10.9 kg) were tested for agility performance using the IAT after different warm-up protocols consisting of static, dynamic, combined stretching, and no stretching. The players were subgrouped into less and more experienced players (5.12 ± 0.83 and 8.18 ± 1.16 years, respectively). There were significant decreases in agility time after no stretching, among no stretching vs. static stretching; after dynamic stretching, among static vs. dynamic stretching; and after dynamic stretching, among dynamic vs. combined stretching during warm-ups for the agility: mean ± SD data were 14.18 ± 0.66 seconds (no stretch), 14.90 ± 0.38 seconds (static), 13.95 ± 0.32 seconds (dynamic), and 14.50 ± 0.35 seconds (combined). There was significant difference between less and more experienced players after no stretching and dynamic stretching. There was significant decrease in agility time following dynamic stretching vs. static stretching in both less and more experienced players. Static stretching does not appear to be detrimental to agility performance when combined with dynamic warm-up for professional soccer players. However, dynamic stretching during the warm-up was most effective as preparation for agility performance. The data from this study suggest that more experienced players demonstrate better agility skills due to years of training and playing soccer.
An exploratory investigation of elders' views on diet, nutrition and cancer prevention.

The goal of this exploratory investigation was to describe views related to diet and cancer prevention among the residents of a southwestern retirement community. Ethnographic interviews were conducted with twelve residents, providing over 500 data bits for this investigation. Several categories representative of the elders' views related to diet and cancer prevention were identified using content analysis. These included Determinants of food choices, Vigilance and diet and Expectations related to diet and cancer prevention. Two cultural themes illustrated the semantic relationships among the categories: "It's not easy to change your diet, especially when you are all alone," and "Eating right helps you resist disease but it is just too late for us. " As diet becomes a primary means of reducing one's risk for certain types of cancer, the informed expertise of nutrition educators and health practitioners is needed to assist the public in adopting dietary guidelines. Qualitative data, as presented here, will be useful in developing effective education materials to meet this need.
Classification of inflammatory bowel disease: the old and the new

Purpose of review Inflammatory bowel diseases (IBDs) are disorders of multifactorial cause that present as a multitude of phenotypes, clinical behaviours and severity. Crohn's disease and ulcerative colitis are considered as the two extremes of what is believed to be a spectrum of chronic gut inflammation and this separation is still the first classification used when confronted with an IBD patient. An accurate classification within IBD has several benefits, with respect to patient counselling, assessing risk for disease progression, and particularly with respect to choosing the most appropriate therapy for an individual patient. Basic scientists on the other hand prefer classifications that would allow to better understand the pathophysiology of the different manifestations of Crohn's disease and ulcerative colitis. Recent findings Attempts to reclassify IBD based on recent genetic, serologic or immunologic findings have been made. Most, however, have not been translated to daily practice and need confirmation first. Summary Clinicians should apply a systematic approach to their patients by using existing phenotypic classifications such as Montreal or Paris. They should further recognize clinical and endoscopic features of bad outcome such as perianal disease, deep ulcers on colonoscopy and extensive small bowel involvement.
Modeling Attention in Panoramic Video: A Deep Reinforcement Learning Approach

Panoramic video provides immersive and interactive experience by enabling humans to control the field of view (FoV) through head movement (HM). Thus, HM plays a key role in modeling human attention on panoramic video. This paper establishes a database collecting subjects' HM positions on panoramic video sequences. From this database, we find that the HM data are highly consistent across subjects. Furthermore, we find that deep reinforcement learning (DRL) can be applied to predict HM positions, via maximizing the reward of imitating human HM scanpaths through the agent's actions. Based on our findings, we propose a DRL based HM prediction (DHP) approach with offline and online versions, called offline-DHP and online-DHP. In offline-DHP, multiple DRL workflows are run to determine potential HM positions at each panoramic frame. Then, a heat map of the potential HM positions, named the HM map, is generated as the output of offline-DHP. In online-DHP, the next HM position of one subject is estimated given the currently observed HM position, which is achieved by developing a DRL algorithm upon the learned offline-DHP model. Finally, the experimental results validate that our approach is effective in offline and online prediction of HM positions for panoramic video, and that the learned offline-DHP model can improve the performance of online-DHP.
Environmental pollution due to cadmium: measure of semen quality as a marker of exposure and correlation with reproductive potential.

PURPOSE Contradictory reports exist in the literature regarding an association of cadmium with parameters of semen quality. The aim of the study was to assess cadmium levels in both blood and seminal plasma and to analyze the relationships between cadmium concentrations and lifestyle and semen parameters. MATERIAL AND METHODS Fifty healthy male volunteers were recruited to provide semen and blood samples. Each patient completed an extensive questionnaire regarding his occupation, residence, social status, diet, water source, smoking habits, and medical and surgical history. Semen analysis was carried out according to WHO guidelines. Detection of cadmium in both semen and blood samples was carried out by means of atomic absorption spectrophotometer. RESULTS Mean concentrations of cadmium were 8.18 ± 1.6 ng/ml in blood samples and 2.56 ± 0.9 ng/ml in semen samples. Cadmium blood levels were significantly higher in men from industrialized areas and in current smokers, but were not correlated with semen levels. A significant positive correlation was found between cadmium blood levels, number of immotile spermatozoa, and teratozoospermia index (TZI). Significant inverse relationships between cadmium blood concentration and type-a and type a + b motility were found. CONCLUSIONS The present data show a significant correlation between blood cadmium concentrations, cigarette smoking, occupational exposure, and parameters of semen quality. Such a reduction in spermiogenetic function could be an early marker of a toxic effect by cadmium pollution.
Building a Conversational Agent Overnight with Dialogue Self-Play

We propose Machines Talking To Machines (M2M), a framework combining automation and crowdsourcing to rapidly bootstrap end-to-end dialogue agents for goal-oriented dialogues in arbitrary domains. M2M scales to new tasks with just a task schema and an API client from the dialogue system developer, but it is also customizable to cater to task-specific interactions. Compared to the Wizard-of-Oz approach for data collection, M2M achieves greater diversity and coverage of salient dialogue flows while maintaining the naturalness of individual utterances. In the first phase, a simulated user bot and a domain-agnostic system bot converse to exhaustively generate dialogue "outlines", i.e. sequences of template utterances and their semantic parses. In the second phase, crowd workers provide contextual rewrites of the dialogues to make the utterances more natural while preserving their meaning. The entire process can finish within a few hours. We propose a new corpus of 3,000 dialogues spanning 2 domains collected with M2M, and present comparisons with popular dialogue datasets on the quality and diversity of the surface forms and dialogue flows.
A Human Herpesvirus MicroRNA Inhibits p21 Expression and Attenuates p21-Mediated Cell Cycle Arrest

ABSTRACT The oncogenic human gammaherpesvirus Kaposi's sarcoma-associated herpesvirus (KSHV) expresses 12 viral microRNAs (miRNAs) in latently infected cells. Here, we report that cellular mRNAs encoding the cellular cyclin-dependent kinase inhibitor p21, a key inducer of cell cycle arrest, are direct targets for KSHV miR-K1. Ectopically expressed KSHV miR-K1 specifically inhibited the expression of endogenous p21 in KSHV-negative cells and strongly attenuated the cell cycle arrest that normally occurs upon p53 activation, yet miR-K1 did not prevent the induction of other p53-responsive genes. Stable knockdown of miR-K1 in latently KSHV-infected human primary effusion lymphoma (PEL) B cells revealed a derepression of p21 expression and enhanced cell cycle arrest following activation of p53. Our data demonstrate that miR-K1 represses the expression of p21, a protein with known tumor suppressor functions, and suggest that this KSHV miRNA is likely to contribute to the oncogenic potential of this opportunistic viral pathogen.
Predictive factors for prostatic involvement by transitional cell carcinoma of the bladder.

PURPOSE To evaluate the predictive factors for prostatic involvement according to the bladder transitional cell carcinoma (TCC) characteristics in a prospective study. MATERIALS AND METHODS Hundred patients with the bladder TCC who had undergone standard radical cystoprostatectomy were enrolled in this study. A number of factors, including vascular and perineural invasion, number of tumors, maximum diameter of the tumor, presence of carcinoma in situ, distance between the tumor and the bladder neck, grade, and local stage of the tumor were recorded, and their relationships with prostatic involvement were studied. In addition, hydronephrosis and age of the patients were included in the analysis. RESULTS The mean age of the patients was 62.6 ± 10.8 years. Of a total of 100 patients, 21 (75%) were found to have prostatic involvement with TCC. Univariate statistical analysis showed that vascular invasion and the distance between the tumor and the bladder neck were significantly related to the prostatic involvement (P = .001 and P < .001) and tumor stage had relatively low P value (P = .08). In the logistic regression, only the distance between the tumor and the bladder neck was found to be significantly related to the prostatic involvement (P = .004). CONCLUSION This study demonstrated that distance between the tumor and the bladder neck is a predictive factor for prostatic involvement; hence, prostate-sparing or capsule-sparing cystectomy in patients with tumors in short distances from prostatovesical junction is not rationale and should be avoided.
Hepatitis B surface antigenemia in chronic hemodialysis patients: effect of hepatitis B immunization

OBJECTIVE:Hemodialysis patients with hepatitis B surface antigen (HBsAg) are considered to have the hepatitis B virus (HBV) and are segregated to limit transmission. However, transient de novo HBsAg has been identified in hemodialysis patients shortly after vaccination. Our hypothesis is that immunization rather than actual HBV infection is the most common cause of de novo HBsAg among hemodialysis patients.METHODS:We performed a prospective study between January, 1998 and June, 2000 of de novo HBV infection in over 2400 hemodialysis patients who were screened monthly for HBsAg using a standard enzyme immunoassay. Positive results were confirmed with a neutralization assay. If the confirmatory test was positive, anti-hepatitis B core antibody IgM testing was performed.RESULTS:We identified nine patients with de novo HBsAg confirmed with the neutralization assay. In eight of the nine patients with de novo HBsAg (89%), HBsAg was temporally related to HBV immunization. In none of these eight patients was there a detectable anti-hepatitis B core antibody IgM, an elevated ALT level, or clinical history suggestive of recent hepatitis. The mean age (± SD) of the four men and four women was 56.4 ± 18.8 yr. HBsAg was detectable within 3 days of immunization in most patients.CONCLUSIONS:Our results suggest that HBV immunization is the most common cause of detectable HBsAg in hemodialysis patients. Hemodialysis patients should not be screened for HBV within a week of immunization, and caution should be exercised when interpreting HBsAg seropositivity within 4 wk of HBV immunization.
GeneXpert MTB/RIF Testing in the Management of Patients with Active Tuberculosis; A Real Life Experience from Saudi Arabia

Background GeneXpert MTB/RIF is a real-time PCR assay with established diagnostic performance in pulmonary and extra-pulmonary forms of tuberculosis. The aim of this study was to assess the contribution of GeneXpert MTB/RIF assay to the management of patients with any form of active tuberculosis in a single large tertiary center in Saudi Arabia, with a special focus on the impact on time to start of antituberculous therapy compared with Ziehl-Neelsen (ZN) smears and mycobacterial cultures. Materials and Methods Clinical, radiological and laboratory records for all patients who were commenced on antituberculous therapy between March 2011 and February 2013 were retrospectively reviewed. Results A total of 140 patients were included, 38.6% of which had pulmonary tuberculosis. GeneXpert MTB/RIF was requested for only 39.2% of patients and was the only reason for starting antituberculous therapy for only 12.1%. The median time to a positive GeneXpert MTB/RIF result was 0 days (IQR 3) compared with 0 day (IQR 1) for smear microscopy (P > 0.999) and 22 days (IQR 21) for mycobacterial cultures (P < 0.001). No patients discontinued antituberculous therapy because of a negative GeneXpert MTB/RIF result. Conclusions In a setting wherein physicians are highly experienced in the diagnosis and treatment of tuberculosis, GeneXpert MTB/RIF was remarkably under-utilized and had only a limited impact on decisions related to starting or stopping antituberculous therapy. Cost-effectiveness and clinical utility of routine testing of all smear-negative clinical samples submitted for tuberculosis investigations by GeneXpert MTB/RIF warrant further study.