Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effects of an Educational Program on Using Dietary Approach to Reduce High Blood Pressure in Khartoum State, Sudan (2015)

Background: Sudan is considered one of the leading countries in Africa for the prevalence of hypertension. However, a proper national registry on hypertension is not available in Sudan and evaluation studies are rarely done. Nevertheless, a recent study showed an increase in incidences of hypertension in Sudan. The DASH (Dietary Approaches to Stop Hypertension) diet, which is rich in fruits, vegetables, and low-fat dairy foods, significantly lowers the blood pressure. Objective: To examine the effectiveness of dietary approach to reduce hypertension (DASH) in the reduction of high blood pressure among hypertensive patients. Design: This research is an interventional case control community base study which was carried in 100 patients; 69 females and 31 males were selected by convenient sampling method. They were divided into two groups by simple random sampling 50 patients assigned in the case group and 50 in control group then followed every one separately for ten months. Intervention: The case group were taught individually about dietary approach to reduce hypertension DASH and each participant in case group possessed a book for teaching program to eat food low in saturated fat, cholesterol, total fat and emphasize fruits, vegetables, and fat-free or low-fat milk and milk products; then blood pressure measured monthly for both case and control group for ten month. Result: The study shows decrease in systolic blood pressure among patients who followed dietary approach and received teaching significantly in 4th month (p = 0.032) and diastolic blood pressure became significantly in 6th month (p = 0.032) and became more significant in next four months without change in control group. Conclusion: The study concluded that a diet rich in fruits, vegetables, and low-fat dairy foods, reduced saturated and total fat can substantially lower blood pressure. Recommendation: It is necessary to apply a nutritional approach among all hypertensive patients because it could minimize both the healthcare workload and the money cost for therapy in clinical area.
Extended Gloss Overlaps as a Measure of Semantic Relatedness

This paper presents a new measure of semantic relatedness between concepts that is based on the number of shared words (overlaps) in their definitions (glosses). This measure is unique in that it extends the glosses of the concepts under consideration to include the glosses of other concepts to which they are related according to a given concept hierarchy. We show that this new measure reasonably correlates to human judgments. We introduce a new method of word sense disambiguation based on extended gloss overlaps, and demonstrate that it fares well on the SENSEVAL-2 lexical sample data.
The University of Pennsylvania Smell Identification Test: normative adjustment for Australian subjects

Clinical assessment of olfactory function is not standardised in Australia. Olfactory function is more often tested qualitatively, with no reference to quantitative norms. This practice leads to misdiagnosis, considering the well established differences in olfactory abilities with sex and age. Published norms for the University of Pennsylvania Smell Identification Test (UPSIT), a standardised test of olfactory function, are based upon North American subjects but their utility has not been shown when used for Australian subjects. We matched the scores of Australians tested with the North American English version of the UPSIT with scores of a group of North Americans matched on the basis of race, gender, age and smoking habits. On average, the Australians performed two points lower than the North Americans, suggesting that a test score correction of two points is appropriate when the North American English version of this test is used in Australia.
Ligand-inducible, prostate stem cell antigen (PSCA)-directed GoCAR-T cells in advanced solid tumors: Preliminary results with cyclophosphamide (Cy) ± fludarabine (Flu) lymphodepletion (LD).

2536 Background: Cell-surface protein PSCA is upregulated in many solid tumors and correlates with disease stage. BPX-601, an autologous T-cell product expressing a PSCA-CD3ζ CAR and a rimiducid (Rim)-inducible MyD88/CD40 co-activation switch to augment T-cell proliferation and persistence, is designed to have enhanced efficacy in solid tumors vs traditional CARs. This ongoing first-in-human study assesses safety, biologic, and clinical activity of BPX-601+Rim in PSCA+ cancers. Updated results, including those from patients (pts) who underwent LD with Flu/Cy, are presented. Methods: BP-012 is a 2-part, open-label trial. Part 1 is a 3+3 dose escalation of BPX-601 (1.25–5.0x106 cells/kg; Day [D] 0) given prior to a single, fixed Rim dose (0.4 mg/kg; D7) in pts with previously treated PSCA+ metastatic pancreatic, gastric, or prostate cancers with measurable disease. Results: As of Jan-22-2019, 15 pts have received BPX-601±Rim. Two pts at the highest cell dose received Flu/Cy for LD on D−5 to D−3 before BPX-601; LD after Flu/Cy was 96.6% and 84.3%. Thirteen pts received Cy alone on D−3; in these pts, LD ranged from 0–68.6%. Rapid cell expansion by D4 was observed in all pts with peak vector copy number 8.3-fold higher with Flu/Cy (n = 2) vs Cy LD (n = 13). Serum IP-10, IL-6 and TNFα increased > 2-fold from baseline in ≥1 pt in all Rim cohorts, with 3- to 20-fold Rim-dependent cell expansion in 6 pts. No CRS or DLTs were reported. After Rim, one Flu/Cy pt experienced a serious Grade 2 AE (encephalopathy) related to BPX-601+Rim that resolved with IV steroids; despite time-matched nonserious Grade 1 pyrexia, the pt had no other CRS symptoms. After BPX-601+Rim and ≥1 scan, best responses were 8 SD and 3 PD (1 non-evaluable). With a median follow-up of 9.8 wks, time to next treatment (tx) after BPX-601 ranged from 2.7–22.1 wks (n = 8) and ongoing tx-free intervals range from 9.1–30.1 wks (n = 4). Conclusions: BPX-601+Rim was well-tolerated with manageable safety and early evidence of enhanced CAR T-cell expansion and prolonged persistence after Flu/Cy vs Cy. Additional pts will undergo Flu/Cy LD prior to BPX-601 with single- and repeat-dose Rim. Clinical trial information: NCT02744287.
Dizziness: A Practical Approach to Diagnosis and Management

Dizzy patients are notoriously difficult to diagnose as doctors require knowledge spanning several subspecialties, including neurology, otolaryngology, internal medicine and psychiatry. This updated second edition integrates the essential information from these fields, providing advice that is both practical and accessible. Beginning with two jargon-free chapters on anatomy, physiology and examination techniques, the book follows a coherent structure organized according to clinical presentations, such as recurrent vertigo, positional vertigo and chronic dizziness. Each chapter is summarized with a table showing diagnoses and their key features, ensuring that the relevant differential diagnoses are readily available. Access to more than sixty online video clips is included, illustrating bedside findings from pathological nystagmus to specific balance problems. With practical advice offered for a range of difficult clinical situations, this comprehensive guide will enable any doctor to feel confident when confronted with dizzy patients.
Creating a Better Patient Safety Culture in Taiwan: The Viewpoints of Physicians and Registered Nurses

Background: Patient safety culture in healthcare organizations has become an important issue globally for improving medical services. In 2016, Taiwan’s National Health Insurance (NHI) system covered 99.6% of Taiwan’s population. With the enhancement of medical quality, patients expect medical service providers to care more about safety and medical service. Understanding physicians and registered nurses’ attitudes toward patient safety is a critical issue for healthcare organizations wanting to improve the quality of the medical care they provide. Objective: The purpose of this study was to discern physicians and registered nurses’ attitudes toward patient safety using Sexton and colleagues’ Safety Attitudes Questionnaire (SAQ) in order to develop strategies for improving the quality of medical services. Methods: Pearson correlation analyses were conducted to demonstrate the relationships among six patient safety culture dimensions. Physicians and registered nurses were asked to complete the questionnaire in a case hospital in Taiwan in 2016. Results: The results of Pearson correlation analyses demonstrated a strong and positive relationship between perceptions of management and working conditions. Additionally, teamwork climate was highly correlated to safety climate. The results also illustrated that teamwork climate and job satisfaction were significantly related. Conclusion: The assessment of patient safety culture can provide a basis for hospital managers to monitor the quality of the medical care provided at their organizations. Hospital managers should put more efforts into the essentially important elements of patient safety culture, such as teamwork climate, safety climate, perceptions of management, and working conditions, so as to continuously improve the quality of medical care.
Glyphosate for Weed Control in Dormant Bermudagrass

The control of winter annuals in dormant bermudagrass [Cynodon dactylon (L.) Pers. ‘Common’] has not been consistent with available herbicides. Experiments were conducted to evaluate rates and number of glyphosate [N-(phosphonomethyl)glycine] applications for control of winter annuals growing in dormant bermudagrass. Glyphosate applied as a single treatment at 0.6 kg/ha consistently controlled more parsley-piert (Alchemilla microcorpa Boissier Reuter), corn speedwell (Veronica arvensis L.), and henbit (Lamium amplexicaule L.) than paraquat (1,1′-dimethyl-4,4′-bipyridinium ion) or combination treatments of 2,4-D [(2,4-dichlorophenoxy)acetic acid) + mecoprop 2[(4-chloro-o-tolyl)oxy] propionic acid + dicamba (3,6-dichloro-o-anisic acid). There was no difference between glyphosate and paraquat control of annual bluegrass (Poa annua L.) and common chickweed [Stellaria media (L.) Cyrillo]. Glyphosate treatments did not injure the bermudagrass the following spring.
Healthcare utilisation and cost expenditures for pneumonia in individuals with diabetes mellitus in the USA

Abstract Pneumonia is one of the leading causes of hospitalisations among adults in the USA. Individuals with diabetes mellitus (DM) have been associated with increased risk for pneumonia and complications including death. The objectives of this study were to (1) compare the prevalence and healthcare utilisation patterns for pneumonia in individuals with and without DM, and (2) identify risk factors for pneumonia in those with DM. We performed a retrospective, cross-sectional analysis of the US adult population using Medical Expenditure Panel Surveys (MEPS) data from 2014. Overall, the data represented 24 million individuals with DM and 218 million without DM in the USA. The population-based rate for a pneumonia event was 34 per 1000 persons for individuals with DM and 19 per 1000 persons without DM. Compared to the non-DM group, individuals with DM were treated 1.8x, 2.6x and 1.4x more in the ED, hospital and outpatient, respectively. Furthermore, the average cost per pneumonia event was significantly higher among individuals with DM compared to non-DM in the inpatient setting ($11 931 vs. $7751; P < 0.001). Among individuals with DM, female sex, DM complications, smokers and administration of pneumococcal vaccines were significant factors associated with a pneumonia event.
Culture, Health & Sexuality: An International Journal for Research, Intervention and Care

Resumen En las dos u´ltimasde´cadas, enSuda´frica losnacimientos de madresmenores de 20an˜os han seguidodisminuyendo. El motivo de este declive se atribuye a las poli´ticas progresivas de cara´cter social yeducativo, y a reacciones ma´s complacientes por parte de las familias. En este arti´culo utilizamosdatos etnogra´ﬁcos que se recopilaron entre 2001 y 2002 y de nuevo en 2013 con el objetivo deanalizar las percepciones y experiencias de mujeres jo´venes que han tenido hijos a una edadtemprana en los albores del siglo XXI en comparacio´n con mujeres jo´venes una de´cada ma´s tarde.Este arti´culo hace dos contribuciones principales a la bibliografi´a sobre maternidad precoz enSuda´frica. En primer lugar, permite entrever los cambios que han ocurrido con respecto a co´mo lasmujeres jo´venes han vivido el embarazo y la maternidad en la u´ltima de´cada. En segundo lugar,considera los cambios no solamente con relacio´n al tiempo sino tambie´n con respecto a los cambiosimportantes desde el punto de vista social e ideolo´gico.
The design and content of the National Survey of Families and Households.

This paper is a procedural history of the National Survey of Families and Households (NSFH). It attempts to 1) describe the history of the project 2) enumerate some of the major criteria that guided the decisions relating to the design of the survey what it covered and what questions it included and 3) describe the procedures that were used including sample design field procedures and data preparation. The NSFH includes interviews with a probability sample of 13017 respondents. The NSFH sample includes a main cross-section sample of 9643 households plus a double sampling of blacks Puerto Ricans Mexican Americans single-parent families families with stepchildren cohabiting couples and recently married persons. 1 adult per household was randomly selected as the primary respondent. The design is cross-sectional with several retrospective sequences. A considerable amount of life-history information was collected including the respondents family living arrangements in childhood the experience of leaving the parental home marital and cohabitation experience as well as education employment and fertility histories. The cross-sectional design permits the detailed description of past and current living arrangements and other characteristics and experiences and the analysis of the consequences of earlier patterns on current states marital and parenting relationships kin contact and economic and psychological well-being.
Jejunal multiple perforations for combined abdominal typhoid fever and miliary peritoneal tuberculosis

Typhoid fever and tuberculosis, considered rare diseases in western countries, is still considered a notable problem of health issue in developing countries. The gastrointestinal manifestations of typhoid fever are the most common and the typhoid intestinal perforation (TIP) is considered the most dangerous complication. Abdominal localization of tuberculosis is the 6th most frequent site for extra pulmonary involvement, it can involve any part of the digestive system, including peritoneum, causing miliary peritoneal tuberculosis (MPT). This is the case report of a 4 years old girl with multiple jejunal perforations in a setting of contemporary miliary peritoneal tuberculosis and typhoid fever occurred in “Hopital Saint Jean de Dieu” in Tanguietà, north of Benin. The patient was admitted in the emergency department with an acute abdomen and suspect of intestinal perforation, in very bad clinical conditions, underwent emergency laparotomy. The finding was a multiple perforations of the jejunum in a setting of combined abdominal typhoid fever and miliary peritoneal tuberculosis. Typhoid intestinal perforations and peritoneal tuberculosis are a very rare cause of non-traumatic peritonitis in western country, but still common in developing country. Considering the modern migratory flux and the diffusion of volunteer missions all around the world, the western surgeon should know this pathological entities, and the best treatments available, well known by surgeons with experience of working in developing countries. The combination of both TIP and MPT in the same patient, is a very rare finding which can worsen the outcome of the patient itself.
Efeito da L-Glutamina sobre o perfil leucocitário e a função fagocítica de macrófagos de ratos estressados

OBJECTIVE: To verify the effect of the intraperitoneal administration of glutamine previously to a stress situation on the number of blood leukocytes and on the alveolar macrophage phagocytosis rate in rats. METHODS: Male Wistar rats (90 days old) were divided into four experimental group; control (C, n=15), stress (C+E, n=16), glutamine (GLN, n=15), and glutamine + stress (GLN+E, n=16) experimental groups and kept under standard conditions. The GLN and GLN+E groups received L-glutamine (0,2g/kg of body weight) intraperitoneally (ip) during 10 days. Their controls received L-glicine (0,4g of aa/kg of body weight) ip. The animals of C+E and GLN+E groups were submitted to acute restraint stress (40min, 24h after the last amino acid intervention). Total leukocytes were counted by hemocytometer and for differential leukocytes, count smears were used. To evaluate the phagocytosis rate, the alveolar macrophages (1x106 in a RPMI culture) and S. cerevisiae (1x107) yeast were incubated in an incubator (37oC, 5%CO2) for one hour. The ANOVA and TUKEY (post-hoc) tests were used for the statistical analysis of variance and the values were expressed in mean and standard deviation. RESULTS: When compared with the control group, the C+E group presented a decrease in the number of leukocytes and lymphocytes and an increase in the number of neutrophils (p 0.05). CONCLUSION: The administration of L-glutamine intraperitoneally does not attenuate the effect of stress on the number of blood leukocytes and phagocytic function of alveolar macrophages in rats.
Neutrophil CD64 as a diagnostic marker of sepsis in children

Background: Sepsis is one of the leading causes of mortality among children worldwide. Reliable evidence was insufficient in pediatric sepsis and many aspects in clinical practice actually depend on expert consensus with some evidence in adult sepsis. Objective: This study aimed to investigate neutrophil expression of CD64 in septic children and in healthy controls. We hypothesized that these receptors are elevated during sepsis and can be used as a diagnostic marker. Methods: This study was carried out on 50children with pediatric sepsis and 40 apparently healthy children as controls. Cases were recruited from the PICU of Al Zahraa University Hospital, Al-Azhar University for Girls in the period from May 2014 to March 2015. All the cases were assessed clinically and by routine laboratory investigations. Expression of neutrophil CD64 was measured by flow cytometry. Results: The mean CD64 expression in children with sepsis (66.49 ± 23.45) was significantly higher than in the control group (9.39 ± 6.17) p <0.001 . CD64 expression had a significant positive correlation with CRP level ( r =0.416, p <0.003). ROC curve for CD64 expression showed100% sensitivity and specificity. The most common isolated organisms were gram negative organisms mainly E. coli . A highly significant increase was demonstrated in CRP and TLC values in the culture proven sepsis group compared to clinical sepsis group, while there was no statistical significant difference in CD64 values between the two groups. Conclusion: change in cell surface expression of CD64 on peripheral blood neutrophils can be considered a sensitive marker for the detection of pediatric sepsis. Keywords: Neutrophil, CD64, sepsis, children
Brain and cervical cord myelin water imaging in neuromyelitis optica spectrum disorder

2 Acknowledgements . 3 Table of contents . 4 Statement of contributions . 10 List of associated publications . 11 List of abbreviations . 12 List of tables . 15 List of figures . 16 Chapter
Seroprevalence, Demographic and Blood Donation Characteristics of Blood Donors in the Santa Catarina State, Brazil

There is a paucity of publications on regional variations in seroprevalence of infectious diseases in blood donors within Brazilian states, so that suitable time trends can be derived for major demographic groups. A population study of blood donors in the southern state of Santa Catarina, Brazil, was conducted using all computerized records of the blood donors submitted to serologic screening in 2010. The subjects were predominantly male (57.8%), aged 18-25 years (33.5%), did not direct their donation to any specific recipient (55.6%), nor did they provide another blood donation in last 12 months (58.6%). The highest seroprevalence was observed for the hepatitis B markers (3.0% for anti-HBc and 0.2% for HBsAg), followed by those for syphilis (0, 08% VDRL), HIV-1 (0.06%), hepatitis C (0.05%), HTLV1/2 (0.01%) and Chagas disease (0.01%). The risk factors associated with higher seroprevalence were associated with the first time donation, being male and of older age. Large regional variations were observed, with the Far West region reaching 7% of anti-HBc and 0.5% of HBsAg positive, and the Midwest region showing 0.1% HIV-positive donors. Hepatits B markers of both lifetime and recent infection reached a high level among blood donor candidates in Santa Catarina in 2010 and remain the foremost serological deferral criterion, despite some evidence of the reduced transmission rate compared to the beginning of the decade. The seroprevalence of other sexually transmitted infections (HIV, syphilis) also persisted on a level too high for a blood donor population, implying even higher prevalence in the general population.
Biomarker in insulin resistant and its complication.

Aims: In Type 2 diabetes, Insulin resistant leads microvascular and macrovascular complication. Early finding prevents from this complication and it is a challenging task. A decade research shows adiponectin may be a marker for insulin resistant. Increasing the level of adiponectin prevent the progression of insulin resistant (IR). In this research we are striving adiponectin as a biomarker for insulin resistant also associating the correlation with lipid parameter in the South Indian population. Methods: 30 Type 2 Diabetic patients, 20 Controls were studied. Fasting serum sample were used to measure Adiponectin, Insulin, Lipid parameters (Cholesterol, Triglyceride, HDL) Fasting plasma sample were used to measure Glucose. Anthropometric data including height, weight, BMI and were measured using a standard technique. Results: Wilcoxon signed rank test shows the significant variation between Adiponectin and other analytes. The reduction of mean adiponectin value observed in patient's sample compared to control sample. Insignificant negative correlation between Fasting blood sugar (FBS) and Adiponectin also negative correlation between Adiponectin and Insulin observed. In lipid parameters, significant positive correlation between Adiponectin and HDL and significant negative correlation between Adiponectin and triglyceride observed. Conclusion: Adiponectin might be a prediction for biomarker in Type 2 diabetes associated insulin resistant among South Indians also if test has been done with the high specificity and sensitivity ELISA kit it will improve the insignificant correlation to significant correlation.
The recent upgrades in the "standard" electromagnetic physics package

The current status and the recent developments of Geant4 "Standard" electromagnetic package are presented. The design iteration of the package carried out for the last two years is completed. It provides model versus process structure of the code. The internal database of elements and materials based on the NIST databases is introduced inside the Geant4 toolkit as well. The focus of recent activities is on upgrade of physics models and on validation of simulation results. The significant revisions were done for ionistion models, for models for transition radiation, and multiple scattering models, which are presented in this work. The acceptance suite evolution is also discussed.