Miracle-dz/UniFAR-FTUs huggingface dataset:
Thymoma With Prominent Cystic and Hemorrhagic Changes and Areas of Necrosis and Infarction: A Clinicopathologic Study of 25 Cases

Twenty-five cases of thymoma with prominent cystic and hemorrhagic changes and areas of necrosis and infarction are presented. The patients were 11 women and 14 men between the ages of 18 and 73 years (median 45.5 years). Clinically, nine patients were asymptomatic and their mediastinal tumor was discovered on routine chest radiograph. Sixteen patients presented with symptoms of chest pain and cough. All patients underwent surgical resection of their tumor. Grossly, the tumors were described as well circumscribed and encapsulated, with the exception of two that showed infiltration of pleura and pericardium. The tumors measured from 4 to 13 cm in greatest dimension. On cut surface they showed prominent cystic areas and foci of hemorrhage and necrosis. Histologically, the tumors contained solid areas showing an admixture of round to oval epithelial cells devoid of atypia admixed with small lymphocytes in varying proportions. Cystic changes with areas of necrosis, infarction, and hemorrhage were present in all cases and comprised extensive areas of the tumors. The areas of infarction showed features of ischemic necrosis and were always intimately associated with vaso-occlusive and thrombotic phenomena and with cystic and hyperplastic changes of adjacent thymic epithelium. Clinical follow-up in 14 patients showed that 11 were alive and well from 1 to 18 years after surgery (median follow-up 9 years). Three patients died: one of complications during the immediate postoperative period, one because of colonic adenocarcinoma 9 years after diagnosis of the mediastinal tumor, and one because of pneumonia 6 years later. The two patients with invasive tumors were lost to follow-up. The present study appears to indicate that areas of hemorrhage and necrosis in well encapsulated, noninvasive thymomas do not portend an adverse prognosis.
Factor IX Gene Analysis In 70 Unrelated Patients with Haemophilia B: Description of 13 New Mutations

Summary Seventy unrelated patients suffering from haemophilia B have been screened for determining the molecular defect and for evaluating the spectrum of factor IX mutations in the Rhône Alpes region in France. Most patients were characterized with respect to factor IX antigen and factor IX coagulant activity. We have used denaturing gradient gel electrophoresis to obtain a full scanning of the whole coding, promoter, and exon flanking sequences of the factor IX gene. This technique enabled us to determine the molecular defect in 68 out of 70 families (97%), and the mutation was further identified in the two last patients with a direct sequencing of the gene. A total of 2 complete gene deletions in patients with antifactor IX inhibitor, 6 small insertions/ deletions and 62 point mutations were found. Two of these nucleotide substitutions (Arg145His and Ala233Thr) were detected in 21 patients (30%) suggesting the existence of a local founder effect. Thirteen mutations were previously undescribed, including 7 missense mutations. The detection of mutations in patients affected with haemophilia B may shed some light in the structure-function relationship of factor IX molecule within the coagulation system.
Sex offences against young girls: a long-term record study

Synopsis There have been recent attempts to re-define those offenders who are sufficiently dangerous to justify a longer sentence for their current offence than is normally provided in law, but there is little information about the frequency with which serious sexual offenders are reconvicted. Follow-up studies of the re-conviction in the subsequent 24 years and 15 years of those found guilty of rape, incest, and unlawful sexual intercourse with girls under 13 in 1951 and 1961 have therefore been made. The present paper deals with those prosecuted for unlawful sexual intercourse with girls under 13. The results suggest that there is a low but more persistent tendency to re-conviction than is found in property offenders.
Effect of electoral information communication technologies on employees performance: A case of independent electoral and boundaries commission in Nairobi County, Kenya

vi TABLE OF CONTENTS . vii LIST OF TABLES . ix LIST OF FIGURES . x LIST OF ABBREVIATIONS AND ACRONYMS . xi CHAPTER ONE: INTRODUCTION . 1 1.1 Background . 1 1.2 Statement of the Problem . 7 1.3 Objective of the Study . 8 1.4 Hypotheses of the Study . 9 1.5 Significance of the Study . 9 1.6 Scope of the Study . 10 1.7 Limitation of the Study . 10 1.8 Assumptions of the Study . 11 1.9 Operational Definitions of Terms . 12 CHAPTER TWO: LITERATURE REVIEW . 13 2.
Head trauma and seizures as risk factors of glioblastoma

This is a case-control study of 160 persons with glioblastoma and 128 of their “best friends” as controls. Subjects came mainly from greater Boston, and data were gathered by questionnaire and telephone interview. Among those who had had a “severe” head injury at age 15 or later, the age-adjusted rate ratio (RR) of glioblastoma was 10.6, p = 0.004. There were six cases and no controls who had seizures for 15 or more years. The related RR is inestimable, but has a p value of 0.03. We could not evaluate whether the latter association implies a direct relationship between the causes of seizures and the causes of glioblastoma, or if it reflects the effect of another factor, such as medications to control the seizures.
A Comprehensive Review of the Use of Deep Brain Stimulation (DBS) in Treatment of Psychiatric and Headache Disorders

Neurostimulation as a treatment option for refractory neuropsychiatric disorders has been increasingly utilized in recent years. For patients with such refractory disorders who have often failed to respond to various medical interventions, deep brain stimulation (DBS) has emerged as a promising treatment modality. DBS is a reversible and adjustable form of brain stimulation (also known as functional neurosurgery) in which desired brain structures (or circuits) are given focal electric stimulation via electrodes that are implanted in the brain tissue during a surgical procedure. It has been utilized among various psychiatric and neurological illnesses, in particular headache disorders.
Transport effects on the vertical distribution of tropospheric ozone over western India

In situ tropospheric ozone measurements by balloon‐borne electrochemical concentration cell (ECC) sensors above Ahmedabad in western India from May 2003 to July 2007 are presented, along with an analysis of the transport processes responsible for the observed vertical ozone distribution. This analysis is supported by 12 day back trajectory calculations using the FLEXPART Lagrangian particle dispersion model. Lowest ozone (~20 ppbv) is observed near the surface during September at the end of the Asian summer monsoon season. Average midtropospheric (5–10 km above sea level) ozone is greatest (70–75 ppbv) during April–June and lowest (40–50 ppbv) during winter. Ozone variability is greatest in the upper troposphere with higher ozone during March–May. The FLEXPART retroplume results show that the free tropospheric vertical ozone distribution above this location is affected by long‐range transport from the direction of North Africa and North America. Ozone levels are also affected by transport from the stratosphere particularly during March–April. The lower tropospheric (<3 km) ozone distribution during the Asian summer monsoon is affected by transport from the Indian Ocean via the east coast of Africa and the Arabian Sea. Influence from deep convection in the upper troposphere confined over central Asia has been simulated by FLEXPART. Lower ozone levels are observed during August–November than in any other season at 10–14 km above sea level. These in situ observations are in contrast to other studies based on satellite data which show that the lowest ozone values at these altitudes occur during the Asian summer monsoon.
RetinaCAD - Retinal Computer-Aided Diagnosis System

This paper presents an automatic application that provides several retinal image analysis functionalities, namely vessel segment atio , vessel width estimation, artery/vein classification and optic dis c segmentation. A pipeline of these methods allows the computation of importa nt vessel related indexes, namely the Central Retinal Arteriolar Equiv alent (CRAE), Central Retinal Venular Equivalent (CRVE) and Arteriolarto-Venular Ratio (AVR), as well as various geometrical features associat ed with vessel bifurcations.
Shifting Journalistic Paradigms

This study examines shifting journalisticparadigms in a transitional society. Analyzing data from surveys of journalists and journalism students in the People’s Republicof China, the authors find that professional journalism has emerged as a direct competitor to the party-journalism paradigm. Although the former is manifested in journalists’ positive appraisal of professional news media, the latter is embodied in praising the official party organs. The professional perspective is associated with emphasis on the disseminator role of the media and the desire for more liberal arts training in journalism, whereas the party-journalism paradigm is related to the emphasis on the interpretive and popular advocacy roles and the desire for more training in communist propaganda. The two journalistic paradigms are also reflected in differences in evaluating various innovative media outlets in the reforms. The implications of the findings for studies on the articulation of professionalism and other journalism paradigms are discussed.
Recurrence, submicroscopic complexity, and potential clinical relevance of copy gains detected by array CGH that are shown to be unbalanced insertions by FISH.

Insertions occur when a segment of one chromosome is translocated and inserted into a new region of the same chromosome or a non-homologous chromosome. We report 71 cases with unbalanced insertions identified using array CGH and FISH in 4909 cases referred to our laboratory for array CGH and found to have copy-number abnormalities. Although the majority of insertions were non-recurrent, several recurrent unbalanced insertions were detected, including three der(Y)ins(Y;18)(q? 11.2;p11.32p11.32)pat inherited from parents carrying an unbalanced insertion. The clinical significance of these recurrent rearrangements is unclear, although the small size, limited gene content, and inheritance pattern of each suggests that the phenotypic consequences may be benign. Cryptic, submicroscopic duplications were observed at or near the insertion sites in two patients, further confounding the clinical interpretation of these insertions. Using FISH, linear amplification, and array CGH, we identified a 126-kb duplicated region from 19p13.3 inserted into MECP2 at Xq28 in a patient with symptoms of Rett syndrome. Our results demonstrate that although the interpretation of most non-recurrent insertions is unclear without high-resolution insertion site characterization, the potential for an otherwise benign duplication to result in a clinically relevant outcome through the disruption of a gene necessitates the use of FISH to determine whether copy-number gains detected by array CGH represent tandem duplications or unbalanced insertions. Further follow-up testing using techniques such as linear amplification or sequencing should be used to determine gene involvement at the insertion site after FISH has identified the presence of an insertion.
Prevalence of myopia in Danish conscripts.

PURPOSE This study aimed to determine the prevalence of myopia among Danish conscripts and compare the results with those from similar Danish studies carried out in 1882 and 1964. Furthermore, the relationships between myopia and educational level, ethnicity, intelligence (IQ), body mass index (BMI) and height were analysed. METHODS We carried out a cross-sectional study based on medical reports for 4681 male conscripts. The following data were collected from September to December 2004: age; place of birth; weight; height; power of spectacles or contact lenses; visual acuity; number of years at school (8-13 years); occupation; intelligence test (IQ test) score, and ethnicity. RESULTS The prevalence of myopia (<or= - 0.5 D, spherical equivalent) was 12.8% (95% confidence interval [CI]+/- 0.96); the prevalence of high myopia (< - 6.5 D) was 0.3% (95% CI +/- 0.15). Myopes scored higher (45.3 [SD 9.4]) on IQ tests than emmetropes (41.4 [SD 10.4]) (p < 0.001) and had a higher educational level. No relationship was found between myopia and BMI, height or ethnicity. CONCLUSIONS The study reports a significantly decreasing prevalence of low myopia among Danish conscripts in 2004 compared with 1964. Compared with the results from the 1882 study, the prevalence of low myopia seems stable. The prevalence of high myopia has decreased significantly since 1882 and has also tended to decrease from 1964. Number of years in education and IQ test score were related to myopia.
Role of Immunoglobulin A Monoclonal Antibodies against P23 in Controlling Murine Cryptosporidium parvum Infection

ABSTRACT Cryptosporidium parvum is an important diarrhea-causing protozoan parasite of immunocompetent and immunocompromised hosts. Immunoglobulin A (IgA) has been implicated in resistance to mucosal infections with bacteria, viruses, and parasites, but little is known about the role of IgA in the control of C. parvuminfection. We assessed the role of IgA during C. parvum infection in neonatal mice. IgA-secreting hybridomas were developed by using Peyer’s patch lymphocytes from BALB/c mice which had been orally inoculated with viable C. parvumoocysts. Six monoclonal antibodies (MAbs) were selected for further study based on indirect immunofluorescence assay reactivity with sporozoite and merozoite pellicles and the antigen (Ag) deposited on glass substrate by gliding sporozoites. Each MAb was secreted in dimeric form and recognized a 23-kDa sporozoite Ag in Western immunoblots. The Ag recognized comigrated in sodium dodecyl sulfate-polyacrylamide gel electrophoresis with P23, a previously defined neutralization-sensitive zoite pellicle Ag. MAbs were evaluated for prophylactic or therapeutic efficacy against C. parvum, singly and in combinations, in neonatal BALB/c mice. A combination of two MAbs given prophylactically prior to and 12 h following oocyst challenge reduced the number of intestinal parasites scored histologically by 21.1% compared to the numbers in mice given an isotype-matched control MAb (P < 0.01). Individual MAbs given therapeutically in nine doses over a 96-h period following oocyst challenge increased efficacy against C. parvuminfection. Four MAbs given therapeutically each reduced intestinal infection 34.4 to 42.2% compared to isotype-matched control MAb-treated mice (P < 0.05). One MAb reduced infection 63.3 and 72.7% in replicate experiments compared to isotype-matched control MAb-treated mice (P < 0.0001). We conclude that IgA MAbs directed to neutralization-sensitive P23 epitopes may have utility in passive immunization against murineC. parvum infection.
Supplementary motor area deactivation impacts the recovery of hand function from severe peripheral nerve injury

Although some patients have successful peripheral nerve regeneration, a poor recovery of hand function often occurs after peripheral nerve injury. It is believed that the capability of brain plasticity is crucial for the recovery of hand function. The supplementary motor area may play a key role in brain remodeling after peripheral nerve injury. In this study, we explored the activation mode of the supplementary motor area during a motor imagery task. We investigated the plasticity of the central nervous system after brachial plexus injury, using the motor imagery task. Results from functional magnetic resonance imaging showed that after brachial plexus injury, the motor imagery task for the affected limbs of the patients triggered no obvious activation of bilateral supplementary motor areas. This result indicates that it is difficult to excite the supplementary motor areas of brachial plexus injury patients during a motor imagery task, thereby impacting brain remodeling. Deactivation of the supplementary motor area is likely to be a serious problem for brachial plexus injury patients in terms of preparing, initiating and executing certain movements, which may be partly responsible for the unsatisfactory clinical recovery of hand function.
Gastrointestinal and immunological responses of senior dogs to chicory and mannan-oligosaccharides

Thirty-four senior dogs (pointers 8 - 11 years, beagles 9 - 11 years) were used to evaluate the effects of oligosaccharides on nutritional and immunological characteristics. Dogs were randomly allotted to treatments [1% chicory (CH), 1% mannan-oligosaccharide (MOS), 1% chicory + 1% MOS (CM), or no supplementation (control, CON)] in a parallel design with a 4 week baseline period followed by a 4 week treatment period. Dietary supplementation with MOS or CM tended (P = 0.07) to increase food intake due, in part, to an increase in fermentable fibre and a decrease in energy content of the diet. Although wet faecal output increased (P < 0.05) for dogs supplemented with MOS or CM, when corrected for food intake, no differences were noted. The CM treatment increased (P < 0.05) faecal score (1 = hard and dry, 5 = watery liquid), although these scores remained in a desirable range (3 to 3.5). Chicory supplementation increased (P = 0.07) fat digestibility. Chicory or MOS increased (P ⩽ 0.05) faecal bifidobacteria concentrations 0.4 and 0.5 log10 cfu/g DM, respectively, compared to the CON, while MOS decreased (P < 0.05) faecal E. coli concentrations. Oligosaccharides did not affect white blood cell (WBC) concentrations, but CH and CM tended to increase (P = 0.10) neutrophil concentrations compared to control dogs. Peripheral lymphocyte concentrations were decreased in dogs supplemented with MOS (P = 0.06) and CM (P < 0.05). Chicory and MOS alter faecal microbial populations and certain indices of the immune system of senior dogs.
T-cell Ubiquitin Ligand Affects Cell Death through a Functional Interaction with Apoptosis-inducing Factor, a Key Factor of Caspase-independent Apoptosis*

The lymphoid protein T-cell ubiquitin ligand (TULA)/suppressor of T-cell receptor signaling (Sts)-2 is associated with c-Cbl and ubiquitylated proteins and has been implicated in the regulation of signaling mediated by protein-tyrosine kinases. The results presented in this report indicate that TULA facilitates T-cell apoptosis independent of either T-cell receptor/CD3-mediated signaling or caspase activity. Mass spectrometry-based analysis of protein-protein interactions of TULA demonstrates that TULA binds to the apoptosis-inducing protein AIF, which has previously been shown to function as a key factor of caspase-independent apoptosis. Using RNA interference, we demonstrate that AIF is essential for the apoptotic effect of TULA. Analysis of the subcellular localization of TULA and AIF together with the functional analysis of TULA mutants is consistent with the idea that TULA enhances the apoptotic effect of AIF by facilitating the interactions of AIF with its apoptotic co-factors, which remain to be identified. Overall, our results shed new light on the biological functions of TULA, a recently discovered protein, describing its role as one of very few known functional interactors of AIF.
Antioxidant capacity , total phenolic content and nutritional composition of Asian foods after thermal processing

Asian foods were studied for antioxidant capacity, total phenolics, and nutritional value. Varieties of commonly consumed foods were selected for the present study. They are chicken curry, spicy stir-fried pork, spicy sausage, curry dip, sate sauce (peanut sauce), and a dessert from black glutinous rice. The foods were packed in retort pouches and sterilized to understand the effect of heat on natural antioxidants to scavenge peroxyl radicals (ORAC assay) and DPPH radicals. One hundred grams of examined foods exhibited antioxidant capacity and total phenolic content ranging from 154.15 to 1499.63 μmole trolox equivalent from 7.46 to 40.16 mg vitamin C equivalent (VCE) and from 14.53 to 145.93 mg gallic acid equivalent, respectively. The top three highest foods in antioxidant capacity were Mu phat phrik khing (40.16 mgVCE/100g), Khua kling mu (31.38 mgVCE/100g) and Nam phrik ong (23.54 mgVCE/100g). The results showed that natural antioxidants retained their activity after thermal processing. Total phenolic content have a positive high correlation (r2 = 0.90) with antioxidant capacity. The determined content of protein, fat, total dietary fiber and energy ranged 1.97-22.74, 2.28-24.97, 1.72-6.77 g/100 g and 125-342 Kcal/100 g, respectively.
The approaches to contextual transaction trust computation in e-Commerce environments

In e-commerce environments, the reputation of sellers is a crucial issue to potential buyers in making decisions. Most existing trust evaluation models compute a single value to reflect the general trust level of a seller without taking any transaction context into account. With such a simple trust evaluation model, a buyer may be easily deceived by a malicious seller in a transaction where the notorious value imbalance problem is involved, namely, the malicious seller can accumulate a high level of trust by selling cheap products and then start to deceive buyers by inducing them to purchase expensive products. In this article, we first present a trust vector consisting of four trust values termed as CTT values, the computation of each of which is based on both past transactions and the forthcoming transaction. In addition, in the computation of CTT values, the parameters, such as product category, price range, and time range, can be specified and adjusted by the buyer, yielding different sets of trust values that can outline the seller's reputation profile. As a result, the value imbalance problem potentially existing in a forthcoming transaction can be identified. The computation of CTT values requires the pre-computation of aggregates over large-scale ratings and transaction data with necessary combinations of three dimensions i.e., product category, price, and time, so as to deliver prompt responses to a buyer's query on different CTT values. In solving this challenging problem, we propose three new data structures and algorithms that mainly focus on efficient computation of CTT values. Our experiments conducted on both eBay data sets and large-scale synthetic data sets illustrate the advantages and disadvantages of our proposed approaches when responding to a buyer's CTT queries. Copyright © 2014 John Wiley & Sons, Ltd.