Miracle-dz/UniFAR-FTUs huggingface dataset:
Lattice-reduction aided linear equalizer design for linear complex-field coded OFDM systems

Orthogonal frequency division multiplexing (OFDM) is an effective method to deal with frequency-selective channels since it has low complexity equalization and decoding. To eliminate the effects of the channel nulls and enable multipath diversity, linear complex-field coded (LCFC-) OFDM is introduced and the maximum likelihood decoder is used to collect the diversity. But, the low complexity provided by OFDM is sacrificed. Recently it has been discovered that the performance of linear equalizers may be improved by using lattice-reduction (LR) techniques, in this paper, we analyze the performance of conventional linear equalizers for LCFC-OFDM systems. Then we develop LR aided linear equalizers for LCFC-OFDM systems and prove that complex LR aided linear equalizers collect the same diversity order as that offered by maximum likelihood detectors, but with much lower complexity. Simulation results corroborate the theoretical findings
Panorama da ovinocultura e da caprinocultura a partir do Censo Agropecuário 2017.

A importância economica da agropecuaria traz um crescente interesse no acompanhamento dos seus resultados, pela analise do comportamento dos indicadores, cenarios e perspectivas. A analise de resultados anteriores e fundamental para o entendimento da conjuntura e previsao de tendencias, o que leva em consideracao diversos fatores estruturais e de mercado. Dentre as principais fontes de informacoes da agropecuaria, o Censo Agropecuario realizado pelo Instituto Brasileiro de Geografia e Estatistica - IBGE se destaca e representa a maior base de informacoes para o setor de forma sistematizada. O Censo Agropecuario de 2017, com dados divulgados em carater preliminar, traz uma gama de informacoes estrategicas, que atualizam e incrementam as informacoes disponiveis para auxiliar a elaboracao de estudos e politicas publicas nas diversas cadeias produtivas da agropecuaria. As informacoes contemplam as caracteristicas dos estabelecimentos agropecuarios, caracteristicas dos produtores, informacoes da agroindustria rural, alem de aquicultura, apicultura, horticultura, extracao vegetal, pecuaria, producao vegetal, pessoal ocupado, silvicultura e valores monetarios. O grande diferencial e importância das informacoes do Censo Agropecuario em relacao as demais pesquisas anuais do IBGE, esta no nivel de detalhamento das informacoes, que vai alem do dado de producao, como tambem do levantamento de dados socioeconomicos que caracterizam o produtor e os estabelecimentos agropecuarios, com informacoes estruturais, por exemplo area total, utilizacao da area, estrutura disponivel, praticas adotadas, organizacao do produtor, grau de instrucao, dentre outras muitas informacoes importantes. Portanto, trata-se do retrato mais detalhado disponivel da agropecuaria brasileira, que se presta a muitas analises e estudos com o objetivo de tornar mais eficiente as tomadas de decisoes no setor agropecuario.
Somatic characteristics and cardiovascular risk factors in growth hormone deficiency: A randomized, double‐blind, placebo‐controlled study of the effect of treatment with recombinant human growth hormone

The purpose of the present study was to identify the effect of treatment with recombinant human growth hormone (rhGH) on seven somatic characteristics and eight clinical cardiovascular risk factors. Twenty‐seven male and 24 female patients between the ages of 21 and 60 years were examined. The investigation was a double‐blind, placebo‐controlled study of 12 months duration. Patients were assigned randomly to treatment (T) and placebo (P) groups. In the first 6 months group T received rhGH and group P placebo. In the second 6 months both groups received rhGH. Complete data were available for 23 males and 20 females. Increments were calculated between 6 months –BL (increment 1) and 12–6 months (increment 2) in both T and P groups. Apart from the somatotype, data were analysed with a 2 × 2 mixed analysis of variance (ANOVA) using treatment (rhGH and placebo) and time (increments 1 and 2). Somatotype data were analysed using a 2 × 3 multivariate ANOVA. Three significant interactions were identified in males: waist circumference (P = 0.006), trunk fat (P = 0.0001), and conicity index (P = 0.001). The only significant interaction in females was trunk fat (P = 0.006). In general, treatment and placebo groups responded differently by time and treatment. Responses were similar in males and females. In the first 6 months when group P was on placebo, waist circumference, trunk fat, and conicity index increased slightly; with group T on rhGH somatic variables declined markedly. In the second 6 months when both groups received rhGH there was a marked decline in group P and a continued decline (but less steeply) in group T. In males there were significant decreases in endomorphy in group T and increases in mesomorphy in group P. In females the somatotype remained stable. There were no significant interactions in clinical cardiovascular risk factors in either males or females. Favourable responses occurred in male and female lipid profiles, although these were not significant. It was concluded that in males waist circumference, trunk fat, conicity index, and somatotype responded significantly to treatment with rhGH; in females the only significant response was trunk fat. Am. J. Hum. Biol. 16:533–543, 2004. © 2004 Wiley‐Liss, Inc.
Myelinopathia centralis diffusa (vanishing white matter disease): Evidence of apoptotic oligodendrocyte degeneration in early lesion development

We describe histopathological changes in a 2‐year‐old boy who died from myelinopathia centralis diffusa. Despite extensive white matter destruction, surprisingly high numbers of oligodendrocytes expressing proteolipid protein mRNA were detected. In an active demyelinating lesion in the brainstem, oligodendrocytes showed typical signs of apoptosis. We suggest that death of mature oligodendrocytes is the critical event in the disease.
The Role of Political Intelligence in Firms’ Export Decisions During the Euro Crisis

Inspired by the literatures on internationalization and absorptive capacity, we develop a model exploring how small firms—during crises—acquire and apply political information to export decisions. We test our model using data collected during the 2012 Eurozone crisis from a sample of 440 British, French, and Swedish SMEs. Findings indicate that firms dependent on the Eurozone for exports and heavily impacted by the crisis engaged in frequent political monitoring. In turn, frequent monitoring leads to the development of formal routines for exploiting political information. Firms with the most formal routines sought new export opportunities beyond the Eurozone. In contrast to previous research into small‐firm internationalization, our study stresses the significance of “shortcut” searching activities, non‐market information, and firms’ decisions to reduce prior investments in export markets.
Relationship between intracranial pressure and cortical spreading depression following fluid percussion brain injury in rats.

Traumatic brain injury (TBI) is known to be accompanied by an increase in intracranial pressure (ICP) and in some cases, by spontaneous generation of cortical spreading depression (CSD) cycles. However, the role of CSD in the pathophysiology of cerebral contusion is still unknown. A multiparametric monitoring assembly was placed on the right hemisphere of the rat brain to evaluate ICP, DC potential, extracellular K(+), cerebral blood flow (CBF), and electrocorticogram in 27 rats during 5 h. Fluid percussion brain injury (FPBI) with the magnitude of the impact 2.9, 3.3, 4.1, and 5.0 atmospheres was induced to the left parietal cortex in animal groups A, B, C, and D, respectively. A slow increase in ICP was evident, and was pronounced in group C and especially in group D, where four of nine animals died during the monitoring. At the end of the 5 h experiment, the mean ICP levels were 6.75 +/- 2.87, 8.40 +/- 2.70, 12.75 +/- 4.03, 29.56 +/- 9.25, and the mean total number of CSD cycles was 2.00 +/- 1.41, 4.29 +/- 4.23, 11.71 +/- 13.29, and 20.11 +/- 19.26 in groups A, B, C, and D, respectively. The maximal level of intensity of CSD cycle generation after FPBI was obtained in group D, where almost constant activity was maintained until the end of the experiment. A significant coefficient of correlation between ICP level and total number of CSD cycles was found for all ICP measurements (r = 0.47-0.63, p < 0.05, n = 27), however more significant (p < 0.001) was the coefficient during the period of monitoring between 2 and 4 h after FPBI. Our results suggest that numerous repeating CSD cycles are typical phenomena in moderate and especially severe forms of FPBI. The rising number of CSD cycles under condition of an ICP level >/=20 mm Hg may demonstrate, with high probability, the unfavorable development of TBI, caused by growing secondary hypoxic insult.
MICROENCAPSULATION OF BERGAMOT PEEL ESSENTIAL OIL WITH GUM ARABIC AND MALTODEXTRIN BLENDS: STABILITY AND RELEASE CHARACTERISTICS OF THE ESSENTIAL OIL COMPOUNDS

Bergamut ucucu yagi, gida, icecek, sekerleme ve kozmetik endustrilerinde kullanimi olan degeri yuksek olan bir ucucu yagdir. Yuksek ucuculugu ve cevresel etkilere karsi duyarliligi nedeniyle, bergamut ucucu yaginin raf omru boyunca stabilitesini korumak icin koruyucu onlemler alinmasi gerekmektedir. Bu calismanin amaci, farkli tasiyici materyallerle kapsullenmesi, ve bu materyallerin mikrokapsullerde urun verimi, kapsulleme verimi, fiziksel ve kimyasal ozellikler uzerine etkilerinin incelenmesidir. Bu amacla, farkli konsantrasyonlarda (100: 0, 0: 100, 25:75, 75:25, 40:60, 60:40) arap zamki ve maltodekstrin (DE 12) kullanilarak bergamut ucucu yagi kapsullenmistir. Elde edilen bergamut ucucu yagi mikrokapsullerinin fiziksel ve kimyasal (terpenoid kompozisyonu) ozellikleri degerlendirilmistir. Ayrica, mikrokapsuller 25°C'de 20 gun boyunca depolanmis ve depolamadan sonra onemli ucucu yag bilesenlerinin icerigi ve stabilitesi belirlenmistir. Emulsiyonlarda, maltodekstrin orani arttiginda urun verimi artmistir ancak arap zamki, ucucu yag bilesiminin daha iyi korunmasini saglamistir.
Liver abscesses in Holstein dairy cattle: 18 cases (1992-2003).

BACKGROUND The characteristic clinical manifestations, clinicopathologic findings, treatment, and outcome of dairy cattle with liver abscess are poorly defined. ANIMALS The study included 18 Holstein cows with liver abscesses. METHODS A retrospective study of medical records was performed. Cattle with liver abscess were identified by ultrasound examination or exploratory laparotomy. RESULTS The most common reason for examination was anorexia (14/18). Five cows had fever, 5 were bradycardic, and 5 were tachycardic. Peritonitis (n=6) and vagal indigestion (n=4) were the most frequently associated diseases. Neutrophilia (n=14), hyperfibrinogenemia (n=11), and high serum globulin concentration (n=10) were characteristic of chronic inflammation. Evidence of liver disease on serum biochemistry profile was uncommon. The most common bacterium isolated from the abscess was Arcanobacterium pyogenes (n=4). Anaerobic bacteria were isolated frequently (n=7). There were 6 polymicrobial isolates, with both aerobic and anaerobic bacteria, out of 8 positive samples. Medical treatment was successful in 5 of 7 cattle. Five cows were euthanized and postmortem examination revealed 2 cattle with thrombosis of caudal vena cava. CONCLUSIONS AND CLINICAL IMPORTANCE Holstein dairy cattle affected by liver abscess exhibit no pathognomonic clinical signs. Clinicopathologic findings were often consistent with a chronic active inflammation. Liver abscesses should be included in the differential diagnosis in cattle with a chronic inflammatory process, cranial peritonitis, or vagal indigestion. Prolonged treatment with antimicrobials might be successful.
Informational Content of Open-to-Close Stock Returns

In the present study, I explore interday correlations between open-to-close and opening stock returns. Employing intraday price data on all the stocks that were S&P 500 Index constituents during the period from 1993 to 2013, I find that stock returns in opening trading sessions systematically tend to be higher following days with relatively low (either negative, or lower than the same day's market) open-to-close returns. Moreover, I explicitly document the tendency of opening stock returns to be reversed (to change their sign) following previous day's open-to-close returns. This kind of price behaviour seems to contradict stock market efficiency, and may be potentially interpreted as stock price ‘corrections’ following their ‘deviations’ from the underlying values caused by noise trading during the continuous trading sessions. Based on this finding, for the sampling period, I construct two different daily-adjusted investment portfolios based on the opening trading sessions and involving a long position in the stocks on the days when their opening returns are expected to be high and a short position in the stocks on the days when their opening returns are expected to be low. Both portfolios are found to yield significantly positive returns, even after accounting for trading commissions, providing an evidence for practical applicability of the documented pattern in opening stock prices.
Localization of a Subset of Yeast mRNAs Depends on Inheritance of Endoplasmic Reticulum

Localization of messenger RNA (mRNAs) contributes to generation and maintenance of cellular asymmetry, embryonic development and neuronal function. The She1‐3 protein machinery in Saccharomyces cerevisiae localizes >30 mRNAs to the bud tip, including 13 mRNAs encoding membrane or secreted proteins. Ribonucleoprotein (RNP) particles can co‐localize with tubular endoplasmic reticulum (ER) structures that form the initial elements for segregation of cortical ER (cER), suggesting a coordination of mRNA localization and cER distribution. By investigating localization of MS2‐tagged mRNAs in yeast defective at various stages of cER segregation, we demonstrate that proper cER segregation is required for localization of only a subset of mRNAs. These mRNAs include WSC2, IST2, EAR1 and SRL1 that encode membrane or ER associated proteins and are expressed during S and G2 phases of the cell cycle when tubular ER movement into the bud occurs. Translation of WSC2 is not required for localization, ruling out co‐translational targeting of this mRNA. Localization of ASH1 mRNA is independent of cER segregation, which is consistent with the expression pattern of ASH1 at late mitosis. Our findings indicate the presence of two different pathways to localize mRNAs to the yeast bud.
miRNA and mRNA cancer signatures determined by analysis of expression levels in large cohorts of patients

Significance The study of mRNA and microRNA (miRNA) expression profiles of cells and tissue has become a major tool for therapeutic development. The results of such experiments are expected to change the methods used in the diagnosis and prognosis of disease. We introduce surprisal analysis, an information-theoretic approach grounded in thermodynamics, to compactly transform the information acquired from microarray studies into applicable knowledge about the cancer phenotypic state. The analysis of mRNA and miRNA expression data from ovarian serous carcinoma, prostate adenocarcinoma, breast invasive carcinoma, and lung adenocarcinoma cancer patients and organ-specific control patients identifies cancer-specific signatures. We experimentally examine these signatures and their respective networks as possible therapeutic targets for cancer in single-cell experiments. Toward identifying a cancer-specific gene signature we applied surprisal analysis to the RNAs expression behavior for a large cohort of breast, lung, ovarian, and prostate carcinoma patients. We characterize the cancer phenotypic state as a shared response of a set of mRNA or microRNAs (miRNAs) in cancer patients versus noncancer controls. The resulting signature is robust with respect to individual patient variability and distinguishes with high fidelity between cancer and noncancer patients. The mRNAs and miRNAs that are implicated in the signature are correlated and are known to contribute to the regulation of cancer-signaling pathways. The miRNA and mRNA networks are common to the noncancer and cancer patients, but the disease modulates the strength of the connectivities. Furthermore, we experimentally assessed the cancer-specific signatures as possible therapeutic targets. Specifically we restructured a single dominant connectivity in the cancer-specific gene network in vitro. We find a deflection from the cancer phenotype, significantly reducing cancer cell proliferation and altering cancer cellular physiology. Our approach is grounded in thermodynamics augmented by information theory. The thermodynamic reasoning is demonstrated to ensure that the derived signature is bias-free and shows that the most significant redistribution of free energy occurs in programming a system between the noncancer and cancer states. This paper introduces a platform that can elucidate miRNA and mRNA behavior on a systems level and provides a comprehensive systematic view of both the energetics of the expression levels of RNAs and of their changes during tumorigenicity.
Ki-67, p53, bcl-2 and bax expression in urothelial carcinomas of urinary bladder

Objective: The most important predictive parameter for the biological behavior of urothelial carcinomas except depth of invasion is the histological grade of the tumor. However, crucial discordances arise between pathologists because of subjectivity in histological grading schemes and these discordances cause difficulties especially in lowgrade tumors. The number of studies aiming to predict the risk of recurrence and progression in urothelial carcinomas has therefore increased in recent years. Our aim in this study was to evaluate the relation of histopathological and clinical characteristics of urothelial carcinomas with proliferation and apoptosis markers and to determine predictive parameters for their biological behavior. Material and Method: This study included 84 previously diagnosed cases of urothelial carcinoma of the urinary bladder. immunohistochemical expressions of Ki-67, p53, bcl-2, and bax were examined in each case. Results: Expressions of Ki-67 and p53 determined a significant relationship between pathological stage and histological grade of the cases. There was no significant relationship between the other apoptotic markers (bcl-2, and bax) and clinical or morphological parameters. Conclusion: We concluded that the evaluation of Ki-67 and p53 expression combined with pathological stage and histological grade may give more accurate information about the biological behavior of urothelial carcinomas of the urinary bladder.
Nucleoid and cytoplasmic localization of small RNAs in Escherichia coli

Abstract Bacterial small RNAs (sRNAs) regulate protein production by binding to mRNAs and altering their translation and degradation. sRNAs are smaller than most mRNAs but larger than many proteins. Therefore it is uncertain whether sRNAs can enter the nucleoid to target nascent mRNAs. Here, we investigate the intracellular localization of sRNAs transcribed from plasmids in Escherichia coli using RNA fluorescent in-situ hybridization. We found that sRNAs (GlmZ, OxyS, RyhB and SgrS) have equal preference for the nucleoid and cytoplasm, and no preferential localization at the cell membrane. We show using the gfp mRNA (encoding green fluorescent protein) that non-sRNAs can be engineered to have different proportions of nucleoid and cytoplasmic localization by altering their length and/or translation. The same localization as sRNAs was achieved by decreasing gfp mRNA length and translation, which suggests that sRNAs and other RNAs may enter the densely packed DNA of the nucleoid if they are sufficiently small. We also found that the Hfq protein, which binds sRNAs, minimally affects sRNA localization. Important implications of our findings for engineering synthetic circuits are: (i) sRNAs can potentially bind nascent mRNAs in the nucleoid, and (ii) localization patterns and distribution volumes of sRNAs can differ from some larger RNAs.
Liquid Chromatography–Mass Spectrometry Method for the Determination of Amlodipine in Human Plasma and its Application in a Bioequivalence Study

Abstract A sensitive and selective liquid chromatographic-mass spectrometric (LC-MS) method for the determination of amlodipine (CAS 88150-42-9) in human plasma has been developed. Sample preparation was based on liquid-liquid extraction using NaOH and cyclohexane. Analytical determination was carried out on a C18 column interfaced with a single quadrupole mass spectrometer. Positive electrospray ionization was employed as the ionization source. The mobile phase was 10 mmol/L ammonium acetate solution-methanol (30 : 70, v/v) at the flow rate of 0.2 mL/min. The method was linear in the concentration range of 0.2–20 ng/mL. The lower limit of quantification was 0.2 ng/mL. Amlodipine was sensitive to UV light. The method was validated in terms of accuracy, precision, absolute recovery, and stability. The intra- and inter-day relative standard deviation across three validation runs over the entire concentration range was less than 8.17%. The accuracy determined at three concentrations (0.4, 2.0 and 10 ng/mL for amlodipine maleate) was within ± 3.17% in terms of relative error. The method herein described was successfully applied for the evaluation of pharmacokinetic profiles of amlodipine maleate tablets in 20 healthy volunteers. The results showed that AUC, Tmax, Cmax and T1/2 between the test and reference formulation have no significant difference (P > 0.05). The relative bioavailability was 103.7 ± 12.3%.
Openness Endangers Your Wealth: Noise Trading and the Big Five

We examine the cross-sectional determinants of individual trading activity based on given Big Five personality traits. Our unique data set is obtained by a self-reported questionnaire with 2147 individual investors. We find that Agreeableness, Extraversion and Openness are central in explaining cross-sectional differences in trading activity. Openness is found to be a main driver of excess trading. Overconfidence as predicted by low levels of Agreeableness relates to excessive trading, while high levels of Extraversion do not. Our performance prediction conditional on investor personality is that Agreeableness saves individual investors from losing money via trading, while Openness will endanger terminal wealth.