Miracle-dz/UniFAR-FTUs huggingface dataset:
Vitamin D3-induced calcemic and phosphatemic responses in the freshwater mud eel Amphipnous cuchia maintained in different calcium environments.

Vitamin D3 (100 ng 100 g body weight-1 day-1) was administered intraperitoneally (i.p.) to the freshwater mud eel Amphipnous cuchia kept in artificial freshwater, calcium-free freshwater, low-calcium freshwater (0.2 mmol/l CaCl2) or calcium-rich freshwater (13.4 mmol/l CaCl2) for 15 days. Analyses of serum calcium and phosphate levels were performed on days 1, 3, 5, 10 and 15 after the beginning of the experiment (six eels from each group at each interval). Administration of vitamin D3 elevated the serum calcium [maximum elevation occurred at day 10 in artificial freshwater (vehicle: 10.55 +/- 0.298, vitamin D: 13.90 +/- 0.324), low-calcium freshwater (vehicle: 11.17 +/- 0.220, vitamin D: 12.98 +/- 0.297) and calcium-rich freshwater (vehicle: 11.24 +/- 0.373, vitamin D: 14.24 +/- 0.208) whereas it occurred at day 5 (vehicle: 8.42 +/- 0.253, vitamin D: 11.07 +/- 0.328) in calcium-free freshwater] and phosphate levels [maximum elevation at day 15 in artificial freshwater (vehicle: 4.39 +/- 0.105, vitamin D: 5.37 +/- 0.121), calcium-free freshwater (vehicle: 4.25 +/- 0.193, vitamin D: 5.12 +/- 0.181), low-calcium freshwater (vehicle: 3.93 +/- 0.199, vitamin D: 5.28 +/- 0.164) and calcium-rich freshwater (vehicle: 3.77 +/- 0.125, vitamin D: 5.46 +/- 0.151)] of the fish maintained in the above mentioned environmental media, but the responses were more pronounced in the fish kept in calcium-rich media.
Generating an In Vitro–In Vivo Correlation for Metabolism and Liver Enrichment of a Hepatitis C Virus Drug, Faldaprevir, Using a Rat Hepatocyte Model (HepatoPac)

Hepatocytes provide an integrated model to study drug metabolism and disposition. As a result of a loss of polarity or a significant decrease in the expression of enzymes and transporters, suspended and sandwich-cultured hepatocytes have limitations in determining hepatocellular drug concentrations. Underprediction of the extent of glucuronidation is also a concern for these hepatocyte models. Faldaprevir is a hepatitis C virus protease inhibitor in late-stage development that has demonstrated significant liver enrichment in in vivo rat models based on quantitative whole-body autoradiography (QWBA) and liver-to-plasma area under-the-curve ratio. In bile duct cannulated rats, the primary biliary metabolite was a glucuronide. Owing to ethical concerns, it is difficult to assess liver enrichment in humans, and a lack of in vitro and in vivo correlation of glucuronidation has been reported. The current study was conducted to verify whether a hepatocyte model, rat HepatoPac, could overcome some of these limitations and provide validity for follow-up studies with human HepatoPac. With rat HepatoPac, liver enrichment values averaged 34-fold and were consistent with rat QWBA (26.8-fold) and in vivo data (42-fold). In contrast, liver enrichment in suspended hepatocytes was only 2.8-fold. Furthermore, the extent of faldaprevir glucuronidation in HepatoPac studies was in agreement with in vivo results, with glucuronidation as the major pathway (96%). Suspended rat hepatocytes did not generate the glucuronide or two key hydroxylated metabolites that were observed in vivo. Overall, our studies suggest that HepatoPac is a promising in vitro model to predict in vivo liver enrichment and metabolism, especially for glucuronidation, and has demonstrated superiority over suspended hepatocytes.
How Do Work Engagement, Workaholism, and the Work-to-Family Interface Affect Each Other? A 7-Year Follow-Up Study

Objective: To investigate the long-term relationships between work engagement, workaholism, work-to-family enrichment, and work-to-family conflict (WFC). Methods: We used structural equation modeling and the three-wave 7-year follow-up data of 1580 Finnish dentists to test our hypotheses. Results: Work engagement and work-to-family enrichment mutually predicted each other, and work engagement also negatively predicted WFC. Workaholism predicted WFC, but not vice versa. Work engagement and workaholism were unrelated over time. Conclusions: The results indicate that beyond its suggested benefits for organizations, work engagement may boost the positive interaction between work and family, whereas workaholism is likely to lead to WFC over time. It is valuable for organizations to distinguish work engagement from workaholism and to enhance the former while preventing the latter to have sustainably hardworking working employees with happy home lives.
Keeping Slug Woman Alive: A Holistic Approach to American Indian Texts

This remarkable collection of eight essays offers a rare perspective on the issue of cross-cultural communication. Greg Sarris is concerned with American Indian texts, both oral and written, as well as with other American Indian cultural phenomena such as basketry and religion. His essays cover a range of topics that include orality, art, literary criticism, and pedagogy, and demonstrate that people can see more than just 'what things seem to be'. Throughout, he asks: How can we read across cultures so as to encourage communication rather than to close it down? Sarris maintains that cultural practices can be understood only in their living, changing contexts. Central to his approach is an understanding of storytelling, a practice that embodies all the indeterminateness, structural looseness, multi valence, and richness of culture itself. He describes encounters between his Indian aunts and Euro-American students and the challenge of reading in a reservation classroom; he brings the reports of earlier ethnographers out of museums into the light of contemporary literary and anthropological theory. Sarris' perspective is exceptional: son of a Coast Miwok/Pomo father and a Jewish mother, he was raised by Mabel McKay - a renowned Cache Creek Pomo basket weaver and medicine woman - and by others, Indian and non-Indian, in Santa Rosa, California. Educated at Stanford, he is now a university professor and recently became Chairman of the Federated Coast Miwok tribe. His own story is woven into these essays and provides valuable insights for anyone interested in cross-cultural communication, including educators, theorists of language and culture, and general readers.
Cumulative Impact of a Clover Cover Crop on the Persistence and Efficacy of Beauveria bassiana in Suppressing the Pecan Weevil (Coleoptera: Curculionidae)

ABSTRACT The pecan weevil, Curculio caryae (Horn), is a key pest of pecan. Endemic levels of the entomopathogenic fungus Beauveria bassiana (Balsamo) Vuillemin can occur in pecan orchards and contribute to natural control of C. caryae. Commercial formulations of the fungus can also be applied for suppression of C. caryae. We hypothesized that a clover cover crop enhances B. bassiana efficacy and persistence (e.g., by protecting the fungus against abiotic environmental stresses). The hypothesis was tested by conducting field trials in a pecan orchard in Byron, GA, in 2009 and 2010. The study included four treatments arranged in a factorial with two levels of fungus (endemic fungus only, and application of a commercial B. bassiana product), and two levels of clover (white clover, Trifolium repens L., and no clover). Fungal persistence was measured by determining the number of CFUs per gram of soil over time (during 42 d postapplication of B. bassiana in 2009 and 29 d in 2010). Efficacy was measured by capturing naturally emerging C. caryae and subsequently determining mortality and mycosis (over 24 d in 2009 and 17 d in 2010). In 2009, greater prevalence of B. bassiana conidia was detected in plots receiving fungal applications compared with no fungus applications, and no clear effect of clover was observed in plots receiving B. bassiana applications in either year. In 2010, B. bassiana prevalence in the endemic fungus plus clover treatment was higher than fungus without clover, and was similar to plots receiving additional B. bassiana applications. Given that we observed enhanced persistence of endemic B. bassiana in 2010 but not 2009, the impact of clover appears to be a cumulative effect. Mortality of C. caryae (averaged over the sampling periods) ranged between 68–74% in plots receiving B. bassiana applications and 51–56% in plots with endemic fungus only. C. caryae mortality and mycosis data also provided evidence that endemic B. bassiana efficacy was enhanced by clover relative to plots without clover (with no clear clover effect on plots receiving fungus applications). Thus, we conclude that natural control of C. caryae can increase when clover is grown in pecan orchards with endemic populations of B. bassiana.
Efecto del estrés térmico sobre la respuesta inmune en trabajadores expuestos a temperaturas abatidas

El estres termico por frio, en el ambiente laboral, puede condicionar enfriamiento general y local, lo que se deriva, en manifestaciones propias de hipotermia hasta lesiones graves como congelamiento y necrosis de las zonas de exposicion (Holmer, 2009). La exposicion al frio es un peligro significativo en la industria tanto en areas artificiales como naturales (Holmer et al., 2009). Si bien son ampliamente conocidas las manifestaciones clinicas progresivas en la hipotermia, aun no son conocidos, en humanos, los efectos de la exposicion laboral al frio, de manera cronica (mayor a 3 meses), en el sistema inmune. De manera que, el objetivo de esta investigacion fue evaluar el efecto del estres termico en la respuesta inmune de trabajadores expuestos a temperaturas abatidas. El procedimiento realizado consistio en 1. - Determinar las condiciones de trabajo en el area laboral del puesto de ayudante de camara, 2. - Se formaron dos grupos: 7 expuestos (GE) y 7 no expuestos (GNE), para posteriormente evaluar el estado general de salud de los integrantes de cada grupo, y finalmente estimar el efecto del estres termico sobre el sistema inmune, por frio en la poblacion expuesta, por medio de la medicion de IgA, IgG, IgM en muestras de sangre y IgA secretora en saliva. Los resultados mostraron diferencia estadisticamente significativa, con valores para IgA serica (׆pנ< 0.05) del GE vs. GNE, no se encontraron valores significativos para el resto de inmunoglobulinas, IgG e IgM serica e IgA en saliva. Con esto, concluimos que el efecto en la respuesta humoral por estres termico, posterior a exposicion a temperaturas de -23 a -28 oC, parece producir, una disminucion en los valores de IgA serica, se desconoce el mecanismo, por el cual se producen estos cambios aparentes, por lo que se deberan realizar mas estudios con un enfoque inmunologico.
Algorithms for automatic modulation recognition of communication signals

This paper introduces two algorithms for analog and digital modulations recognition. The first algorithm utilizes the decision-theoretic approach in which a set of decision criteria for identifying different types of modulations is developed. In the second algorithm the artificial neural network (ANN) is used as a new approach for the modulation recognition process. Computer simulations of different types of band-limited analog and digitally modulated signals corrupted by band-limited Gaussian noise sequences have been carried out to measure the performance of the developed algorithms. In the decision-theoretic algorithm it is found that the overall success rate is over 94% at the signal-to-noise ratio (SNR) of 15 dB, while in the ANN algorithm the overall success rate is over 96% at the SNR of 15 dB.
A Hoard of Samian Ware from Pompeii

During a visit to Naples in June, 1913, I was permitted by the courtesy of Professor Spinazzola, the distinguished Director of the National Museum, to examine a number of decorated bowls of Samian ware obviously of south Gallic style, preserved in the ‘magazzini’ of the museum. Professor Spinazzola most kindly afforded me every facility for their study, and consented to their publication. Seventy-six of these bowls bore, in addition to the inventory-number, the date 1882, and a subsequent reference to three passages in the Notizie degli Scavi made it possible to identify ninety bowls in all as belonging to a group found together at Pompeii. The circumstances of the discovery were as follows: the ninety bowls were found on 4th October, 1881, in the ‘tablinum’ of house 9, insula 5, region viii (ii). They were arranged in order in a wooden box, of which some charred fragments remained, together with thirty-seven earthenware lamps said to have shewn no sign of use. Of these lamps twenty-four bear the stamp STROBILI; six, COMVNIS; four, ECHIO; two, FORTIS; and one is uninscribed. Side by side with this box were found two others, containing red powder, either pounded brick or red earth, the use of which I do not know.
Attachment representations in 6-year-olds: Related longitudinally to the quality of attachment in infancy and mothers' attachment representations

A new method to assess attachment representations in children by applying a story completion procedure in doll play (SCPDP) is presented. Transmission and continuity of attachment were tested in 28 German families by using the Strange Situation procedure (SS) with the mother and her infant, the Adult Attachment Interview (AAI) with the mother when the child is 5 years old, and the attachment representations (SCPDP) of the 6-year-olds. Relying on the twofold distinction (secure/insecure), results revealed a significant continuity of attachment from 1 to 6 years of age, and a correspondence between maternal AAI and child's attachment quality in SS, as well as a correspondence between maternal AAI and the 6-year-olds' attachment representations. Using configural frequency analysis, we found continuity in patterns of security and insecurity when looking across the measures of infant and pre-school attachment and maternal adult attachment. Processes underlying the high match of mothers' and children's attachment representations are discussed.
Masculinity and Mourning in Modern African American Criticism

Nathan Grant's book, Masculinist Impulses: Toomer, Hurston, Black Writing, and Modernity, has a provocative title. Several critical texts in recent years have significantly added to the body of scholarship on black masculinity, and the title of this book seems to indicate that it will augment this scholarship by taking it in directions that are fresh and new. The writers that Grant includes in his study, Jean Toomer, Zora Neale Hurston, John Edgar Wideman, Toni Morrison, and Gloria Naylor, are all canonical ones whom he could use to develop a very pow erful argument. As the title of the book announces, two of its major concepts are "masculinist impulse" and "modernity," and given the title of the Intro duction, "Modernism and the Masculinist Impulse," one would think that it would define these concepts in the context of the book's analy sis and provide its central critical focus. However, the Introduction does not clearly define masculinist impulse, modernity/modernism, or post modern, and the failure to define masculinist impulse? the book's pri
Disparities in perceived unmet need for supportive services among patients with lung cancer in the Cancer Care Outcomes Research and Surveillance Consortium

The authors investigated the prevalence, determinants of, and disparities in any perceived unmet need for 8 supportive services (home nurse, support group, psychological services, social worker, physical/occupational rehabilitation, pain management, spiritual counseling, and smoking cessation) by race/ethnicity and nativity and how it is associated with perceived quality of care among US patients with lung cancer.
The Two Faces of Collaboration: Impacts of University-Industry Relations on Public Research

We analyze the impact of university--industry relationships on public research. Our inductive study of university--industry collaboration in engineering suggests that basic projects are more likely to yield academically valuable knowledge than applied projects. However, applied projects show higher degrees of partner interdependence and therefore enable exploratory learning by academics, leading to new ideas and projects. This result holds especially for research-oriented academics working in the "sciences of the artificial" and engaging in multiple relationships with industry. Our learning-centred interpretation qualifies the notion of entrepreneurial science as a driver of applied university--industry collaboration. We conclude with implications for science and technology policy. Copyright 2009 The Author 2009. Published by Oxford University Press on behalf of Associazione ICC. All rights reserved. , Oxford University Press.
The Histidine Decarboxylase Gene Cluster of Lactobacillus parabuchneri Was Gained by Horizontal Gene Transfer and Is Mobile within the Species

Histamine in food can cause intolerance reactions in consumers. Lactobacillus parabuchneri (L. parabuchneri) is one of the major causes of elevated histamine levels in cheese. Despite its significant economic impact and negative influence on human health, no genomic study has been published so far. We sequenced and analyzed 18 L. parabuchneri strains of which 12 were histamine positive and 6 were histamine negative. We determined the complete genome of the histamine positive strain FAM21731 with PacBio as well as Illumina and the genomes of the remaining 17 strains using the Illumina technology. We developed the synteny aware ortholog finding algorithm SynOrf to compare the genomes and we show that the histidine decarboxylase (HDC) gene cluster is located in a genomic island. It is very likely that the HDC gene cluster was transferred from other lactobacilli, as it is highly conserved within several lactobacilli species. Furthermore, we have evidence that the HDC gene cluster was transferred within the L. parabuchneri species.
Nephrotoxicity of iso-osmolar iodixanol compared with nonionic low-osmolar contrast media: meta-analysis of randomized controlled trials.

PURPOSE To compare the nephrotoxicity of iso-osmolar iodixanol with that of nonionic low-osmolar contrast media (CM) (LOCM) in randomized clinical trials. MATERIALS AND METHODS This meta-analysis was conducted with a systematic search of MEDLINE, EMBASE, BIOSIS, Web of Science, ISI Web of Knowledge, Current Contents Medizin, Cochrane Library (until August 2007), trial registers, conference proceedings, and reference lists to identify studies and with requests from all manufacturers of CM for unidentified studies. Randomized controlled trials assessing serum creatinine levels before and after intravascular application of iodixanol or LOCM were included. The primary outcome measures were the incidence of contrast medium-induced nephropathy (CIN) and change in serum creatinine levels. RESULTS Twenty-five trials were included. Iodixanol did not significantly reduce the risk of CIN (relative risk [RR], 0.80; 95% confidence interval [CI]: 0.61, 1.04; weighted mean difference in serum creatinine increase, 0.01 mg/dL [0.88 mumol/L]; 95% CI: -0.01, 0.03). There was no significant risk reduction after intravenous administration of the CM (RR, 1.08; 95% CI: 0.62, 1.89); subgroup with preexisting renal insufficiency (RR, 1.07; 95% CI: 0.56, 2.02) or after intraarterial administration (RR, 0.68; 95% CI: 0.46, 1.01); subgroup with preexisting renal insufficiency (RR, 0.59; 95% CI: 0.33, 1.07). However, in patients with intraarterial administration and renal insufficiency, the risk of CIN was greater for iohexol than for iodixanol (RR, 0.38; 95% CI: 0.21, 0.68), whereas there was no difference between iodixanol and the other (noniohexol) LOCM (RR, 0.95; 95% CI: 0.50, 1.78). CONCLUSION Iodixanol is not associated with a significantly reduced risk of CIN compared with the LOCM pooled together. However, in patients with intraarterial administration and renal insufficiency, iodixanol is associated with a reduced risk of CIN compared with iohexol, whereas no significant difference between iodixanol and other LOCM could be found.
A new tool for monoclonal antibody analysis

Monoclonal antibody (mAb) products are extraordinarily heterogeneous due to the presence of a variety of enzymatic and chemical modifications, such as deamidation, isomerization, oxidation, glycosylation, glycation, and terminal cyclization. The modifications in different domains of the antibody molecule can result in different biological consequences. Therefore, characterization and routine monitoring of domain-specific modifications are essential to ensure the quality of the therapeutic antibody products. For this purpose, a rapid and informative methodology was developed to examine the heterogeneity of individual domains in mAb products. A recently discovered endopeptidase, IdeS, cleaves heavy chains below the hinge region, producing F(ab')2 and Fc fragments. Following reduction of disulfide bonds, three antibody domains (LC, Fd, and Fc/2) can be released for further characterization. Subsequent analyses by liquid chromatography/mass spectrometry, capillary isoelectric focusing, and glycan mapping enable domain-specific profiling of oxidation, charge heterogeneity, and glycoform distribution. When coupled with reversed phase chromatography, the unique chromatographic profile of each molecule offers a simple strategy for an identity test, which is an important formal test for biopharmaceutical quality control purposes. This methodology is demonstrated for a number of IgGs of different subclasses (IgG1, IgG2, IgG4), as well as an Fc fusion protein. The presented technique provides a convenient platform approach for scientific and formal therapeutic mAb product characterization. It can also be applied in regulated drug substance batch release and stability testing of antibody and Fc fusion protein products, in particular for identity and routine monitoring of domain-specific modifications.
Pregnancy outcomes according to dialysis commencing before or after conception in women with ESRD.

BACKGROUND AND OBJECTIVES Pregnancy in ESRD is rare and poses substantial risk for mother and baby. This study describes a large series of pregnancies in women undergoing long-term dialysis treatment and reviews maternal and fetal outcomes. Specifically, women who had conceived before and after starting long-term dialysis are compared. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENT All pregnancies reported to the Australian and New Zealand Dialysis and Transplantation Registry from 2001 to 2011 (n=77), following the introduction of specific parenthood data collection, were analyzed. RESULTS Between 2001 and 2011, there were 77 pregnancies among 73 women. Of these, 53 pregnancies were in women who conceived after long-term dialysis was established and 24 pregnancies occurred before dialysis began. The overall live birth rate (after exclusion of elective terminations) was 73%. In pregnancies reaching 20 weeks gestation, the live birth rate was 82%. Women who conceived before dialysis commenced had significantly higher live birth rates (91% versus 63%; P=0.03), but infants had similar birthweight and gestational age. This difference in live birth rate was primarily due to higher rates of early pregnancy loss before 20 weeks in women who conceived after dialysis was established. In pregnancies that reached 20 weeks or more, the live birth rate was higher in women with conception before dialysis commenced (91% versus 76%; P=0.28). Overall, the median gestational age was 33.8 weeks (interquartile range, 30.6-37.6 weeks) and median birthweight was 1750 g (interquartile range, 1130-2417 g). More than 40% of pregnancies reached >34 weeks' gestation; prematurity at <28 weeks was 11.4% and 28-day neonatal survival rate was 98%. CONCLUSIONS Women with kidney disease who start long-term dialysis after conception have superior live birth rates compared with those already established on dialysis at the time of conception, although these pregnancies remain high risk.