Miracle-dz/UniFAR-FTUs huggingface dataset:
Common Components in Pollen Extracts

In order to evaluate the clinical relevance of testing with various pollen extracts in a multi‐center investigation from Denmark, 5,052 patients were skin prick tested with the anamnestically relevant extract from a battery of 48. With the aid of a computer program comparing the extracts, two by two calculations were made over the percentage of patients reacting against allergens present in both extracts. Pollen extracts which frequently produce reaction were divided into three separate groups (tree pollen, grass pollen and herb pollen) within which common allergens were so dominant that it seemed advisable in routine examinations to use one extract and one extract only from each group.
Early influences of word length and frequency: a group study using MEG

In what way are linguistic word properties reflected in the neurophysiological brain response? During a memory task we presented written words orthogonally varied in length (long, short) and frequency (high, low). Brain responses of 15 subjects were recorded using a 148-channel magnetoencephalogram. Very early after stimulus onset (60 ms), long words led to significantly stronger activation than short words, as revealed by the global field power (GFP). Later on, low frequency words led to stronger brain responses than high frequency words. This effect depended on word length: it was seen 120–170 ms after stimulus onset, for short words only, but at 225–250 ms exclusively for long words. Source localisation revealed that effects due to word length were pronounced over occipital areas whereas frequency effected more widespread cortical areas with a strong focus over left occipitotemporal areas (visual word form areas).
Star Cluster Simulations Including Stellar Evolution

The past few years have seen dramatic improvements in the scope and realism of star cluster simulations. Accurate treatments of stellar evolution, coupled with robust descriptions of all phases of binary evolution, have been incorporated self-consistently into several dynamical codes, allowing for the first time detailed study of the interplay between stellar dynamics and stellar physics. The coupling between evolution, dynamics, and the observational appearance of the cluster is particularly strong in young systems and those containing large numbers of primordial binary systems, and important inroads have been made in these areas, particularly in N-body simulations. I discuss some technical aspects of the current generation of N-body integrators, and describe some recent results obtained using these codes.
Anaemia and iron deficiency screening in adolescence: a pilot study of iron stores and haemoglobin response to iron treatment in a population of 14—15‐year‐olds in Norway

Screening for haemoglobin (Hb) and s‐ferritin, in 176 of all 189 (93%) pupils at 8th grade (14—15‐years‐old) in one Norwegian community was performed in order to map the prevalence of anaemia and depleted iron stores. In order to determine the clinical significance of the findings, a questionnaire aimed at detecting symptoms or risk factors for iron deficiency was completed by all participants, and a 3 mo therapeutic trial with iron was offered to subjects with s‐ferritin values below 15 p.g/l. Four percent of girls and 8% of boys were anaemic according to WHO cut‐off levels. S‐ferritin < 15 p.g/l was found in 25% of girls and 30% of boys. Forty‐four of 48 pupils with s‐ferritin < 15 p.g/l completed the therapeutic trial. Only three pupils had a clinically significant increase in Hb, representing less than 2% of the population. The questionnaire gave no clues that could identify subjects with depleted iron stores. To increase Hb in one 14—15‐y‐old with depleted iron stores, 59 (95% CHI: 20—285) had to be screened and 16 (6—76) had to be given iron treatment. This pilot study suggests that functional iron deficiency is rare in Norwegian adolescents despite a high frequency of low iron stores. A double blind, placebo controlled study covering the entire span of pubescence is needed to confirm these results. □Adolescence, anaemia, iron deficiency, ferritin, haemoglobin, screening, therapeutic trial
Survival Analysis in Modeling the Birth Interval of the First Child in Indonesia

First birth interval is one of the examples of survival data. One of the characteristics of survival data is its observation period that is fully unobservable or censored. Analyzing the censored data using ordinary methods will lead to bias, so that reducing such bias required a certain method called survival analysis. There are two methods used in survival analysis that are parametric and non-parametric method. The objective of this paper is to determine the appropriate method for modeling the birth of the first child. The exponential model with the inclusion of covariates is used as parametric method, considering that the newly married couples tend to have desire for having baby as soon as possible and such desire will be weakened by increasing age of marriage. The data that will be analyzed were taken from the Indonesia Demographic and Health Survey (IDHS) 2012. The result of data analysis shows that the birth of the first child data is not exponentially distributed thus the Cox proportional hazard method is used. Because of the suspicion that disproportional covariate exists, then the proportional hazard test is conducted to show that the covariate of age is not proportional, the generalized Cox proportional method is used, namely Cox extended that allows the inclusion of disproportional covariates. The result of analysis using Cox extended model indicates that the factors affecting the birth of the first child in Indonesia are the area of residence, educational history and its age.
Sodium currents in smooth muscle cells freshly isolated from stomach fundus of the rat and ureter of the guinea‐pig.

1. Inward currents elicited by depolarization from holding potentials of ‐80 to ‐10 mV in single smooth muscle cells isolated from stomach fundus of the rat and ureter of the guinea‐pig had two components. The initial fast component (Ifi) was activated and mostly inactivated within 1‐2 and 10 ms, respectively, at 21 degrees C. The following sustained component (Isi) lasted over 50 and 500 ms in fundus and ureter cells, respectively. Ifi was blocked by tetrodotoxin but not affected by 0.5 microM‐mu‐conotoxin in both types of cells. Isi was abolished by the substitution of extracellular Ca2+ with Mn2+. 2. The sensitivity of Ifis to TTX was markedly different in fundus and ureter cells. The half‐inhibition was obtained at 870 and 11 nM, respectively. The amplitude of Ifi was highly dependent on extracellular Na+ concentration in a solution containing 2.2 mM‐Mn2+ and 0 mM‐Ca2+ in both cells. It is concluded that Ifis in these cells are TTX‐sensitive and mu‐conotoxin‐insensitive Na+ currents. 3. Some of the kinetics of INa measured at 10 degrees C were markedly different in fundus and ureter cells. The current‐voltage relationships for Ifi in fundus and ureter cells had peaks at about ‐10 and 0 mV, respectively. The voltage dependence of the steady‐state inactivation of Ifi was also significantly different in these cell types. The half‐inactivation voltages were about ‐74 and ‐45 mV, respectively. The recovery time course from inactivation in fundus cells was about 10 times slower than that in ureter at ‐80 mV, where it was 25 ms. 4. The contribution of Ifi to the rising phase of an action potential was examined using TTX under current clamp mode at 21 degrees C. A fast notch‐like potential elicited by a subthreshold stimulus for action potential generation was blocked by TTX in both types of cells. Action potentials elicited by a stimulus around threshold were occasionally suppressed by TTX, whereas an action potential was never observed when extracellular Ca2+ was replaced with Mn2+. 5. In conclusion, the existence of at least two types of Na+ channel currents, which were distinguished by their TTX sensitivity and kinetics, was strongly suggested in smooth muscle cells from the rat fundus and the guinea‐pig ureter. INa in these cells may have a physiological role to accelerate the generation of an action potential by triggering a rapid activation of ICa, while not being essential for activation of action potentials.
Phase stability of wüstite at high pressure from first-principles linearized augmented plane-wave calculations.

We use the local spin-density approximation (LSDA) to investigate the phase stability and physical properties of stoichiometric wustite at high pressure. Highly converged total-energy calculations are presented for nonmagnetic, ferromagnetic, and antiferromagnetic, unstrained B1 and B2, and rhombohedrally strained B1 structures. We find the local magnetic moments are greatly diminished at high pressure, and we expect the LSDA to provide an accurate description of FeO at high pressure. The antiferromagnetic ground state occurs for a small rhombohedral distortion of the B1 structure
Optimizing the Equity-Bond-Annuity Portfolio in Retirement: The Impact of Uncertain Health Expenses

This paper derives optimal equity-bond-annuity portfolios for retired households who face stochastic capital market returns, differential exposures to mortality risk and uncertain uninsured health expenses, and differential Social Security and defined benefit pension coverage. The results show that the health spending risk drives household portfolios to shift from risky equities to safer assets and enhances the demand for annuities due to their increasing-with-age superiority over bonds in hedging against life-contingent health spending and longevity risks. Households with higher income have a greater incremental demand for life annuities. The annuities in turn provide greater leverage for equity investment in the remaining asset portfolios.
Contention free embedding of complete binary trees into 3D meshes in half and full-duplexed network models

We consider the problem of dimension-ordered embedding of complete binary trees into 3-dimensional meshes without link contention. In this paper, the embedding problems are studied under two different network models: half-duplexed networks and full-duplexed networks. Gibbons and Paterson showed that a complete binary tree T/sub p/ could be disjointedly embedded into a full-duplexed 2-dimensional mesh of optimum size without dimension-ordered routing. Using the dimension-ordered routing, the authors showed that T/sub p/ could be embedded into a 3-dimensional mesh of optimum size with link congestion two. This paper presents the dimension-ordered embedding algorithms of the complete binary trees into the wormhole routed 3-dimensional meshes without link contention achieving expansion of no larger than 1.125 of optimum in half-duplexed network model and optimum in full-duplexed network model.
Center and other factor effects in recipients of living-donor kidney transplants.

UNLABELLED 1. LIVING DONOR KIDNEY TRANSPLANTS Using 1996-2001 UNOS Registry data, we assessed the joint influence of center, 19 pre- and 5 posttransplant factors on renal allograft function in 21,830 patients transplanted with living donor kidneys. During an initial risk period, 21,033 recipients were projected to keep their grafts through one year (an average 96.4% one-year graft survival), and, in a second risk period, 17,775 recipients were projected to keep their grafts through 5 years (84.5% conditional 5-year graft survival after surviving one year posttransplant). 2. CENTER EFFECTS: Following multivariate log-linear analysis, 57.5% and 26.5% of assignable variation in one- and 5-year living-donor graft survival rates were due to the variation across 234 transplant centers. Center effect dominated other factors in influencing early outcomes among living kidney donor transplants. A program's size was associated with this center effect since all large centers (400+ living donor kidneys) had better-than-average one-year graft survival rates, whereas smaller centers (< or = 100 grafts) had wide ranges in short-term outcomes (87-100%). Center size did not play a role in explaining long-term variation, and the extent to which uniformity in care remains the responsibility of the original center needs to be investigated. 3. PRETRANSPLANT FACTOR EFFECTS The impact of the 19 pretransplant cofactors on short-term outcomes among living donor transplants was clinically small--adjusted one-year graft survival rates across all categories exceeded 94%. However, their long-term effects were stronger and more typical of cadaveric results. The following 4 factors, each explaining > 10% of the assignable variation in conditional 5-year graft survival, were ranked and independently yielded poor results: 1) kidneys from parental donors; 2) grafts in male recipients; 3) teenage/adult recipients (> 12 years); and 4) black recipients. Recipient's original disease and body mass index, donor's race and age, and HLA matching were highly significant factors, but their impact on long-term graft survival was less than those observed previously in cadaveric renal transplants. 4. POSTTRANSPLANT FACTOR EFFECTS Short- and long-term outcomes were relatively stable regardless of the maintenance drug initiated at hospital discharge. Living donor transplant outcomes were similar for Neoral versus Tacrolimus and for MMF versus azathioprine. Kidney graft survival among living donor transplants was strongly affected by delays in graft function or acute rejection episodes. 5. CONCLUSIONS During the first year posttransplant, the benefits of receiving a living donor kidney (versus a cadaver kidney) mitigate negative cofactor risks of graft failure. Beyond one-year, recipients of living donor kidneys are subjected to the same deleterious effects from cofactors and early posttransplant events that impact the long-term graft survival following cadaveric transplantation.
Niastella gongjuensis sp. nov., isolated from greenhouse soil.

An aerobic, Gram-stain-negative, non-flagellated, long rod or rod-shaped bacterial strain, 5GH22-11, was isolated from a soil sample of a greenhouse in Gongju, Republic of Korea. According to 16S rRNA gene sequence analysis, strain 5GH22-11 showed the highest sequence similarities with Niastella populi THYL-44 (97.1%), Niastella koreensis GR20-10 (95.7%) and Niastella yeongjuensis GR20-13 (95.6%), and ,93% sequence similarity with all other species with validly published names. The phylogenetic tree also showed strain 5GH22-11 formed a compact cluster with members of the genus Niastella. DNA–DNA hybridization revealed strain 5GH22-11 is a novel species, showing far less than 70% DNA–DNA relatedness with Niastella populi THYL-44. Strain 5GH22-11 contained iso-C15 : 0 (34.3%), iso-C17 : 0 3-OH (24.8%) and iso-C15 : 1 G (18.2%) as the major fatty acids; phosphatidylethanolamine, six unknown aminolipids, two unknown lipids and one unknown phospholipid as the polar lipids; and MK-7 as the predominant isoprenoid quinone. The DNA G+C content was 41.4 mol%. Based on these phylogenetic, physiological and chemotaxonomic data, it was demonstrated that strain 5GH22-11 represents a novel species of the genus Niastella, for which the name Niastella gongjuensis sp. nov. is proposed. The type strain is 5GH22-11 (5KACC 173995JCM 19941).
Improvement of Soft Tooling Process Through Particle Reinforcement with Polyurethane Mould

Use of conventional flexible polymeric mould materials yields to longer solidification time of (wax/plastic) patterns in soft tooling process, thereby reducing the rapidity of the process to a great extent, which is not desirable in present competitive market. In this work, approach of particle-reinforcement with mould materials is introduced to reduce the cycle time of Soft tooling process and the resulting cooling time is experimentally investigated in considering a case of manufacturing of a typical wax pattern with aluminium particle filled polyurethane. It is observed that cooling time is significantly reduced particularly with higher loading condition of aluminium filler. This happens due f mould material. However, it is also found that the stiffness of mould becomes simultaneously high due to increase of effective modulus of elasticity of mould material. Realizing these facts, an extensive study is carried out to find the effect on equivalent thermal properties and modulus of elasticity of polyurethane composite mould materials with the reinforcement of aluminium and graphite particles independently through rigorous experimentation and correlation of experimental findings with the models cited in literatures. soft tooling process, flexible polymeric mould material, particle reinforcement, cooling time, equivalent thermal conductivity, equivalent modulus of elasticity
Robust Parameter-Dependent Constrained Model Predictive Control

The problem of robust constrained model predictive control (MFC) of systems with polytopic uncertainty is considered in this paper. New sufficient conditions for the existence of parameter-dependent Lyapunov functions are proposed in terms of linear matrix inequalities (LMIs), which will reduce the conservativeness resulting from using a single Lyapunov function. At each sampling instant, the corresponding parameter-dependent Lyapunov function is an upper bound for a worst-case objective function, which can be minimized using the LMI convex optimization approach. Based on the solution of optimization at each sampling instant, the corresponding state feedback controller is designed, which can guarantee that the resulting closed-loop system is robustly asymptotically stable. In addition, the feedback controller will meet the specifications for systems with input or output constraints, for all admissible time-varying parameter uncertainties. Numerical examples are presented to demonstrate the effectiveness of the proposed techniques.
Transcripts of Calcium/Calmodulin-dependent Kinases are Changed After Forskolin- or IBMX-induced Insulin Secretion due to Melatonin Treatment of Rat Insulinoma β-Cells (INS-1)*

The objective of the present study was to examine the effects of melatonin on transcripts of isoforms of calcium/calmodulin-dependent protein kinases in rat insulinoma beta-cells INS-1. Investigations show that calcium/calmodulin-dependent kinase IV and calcium/calmodulin-dependent kinase 2d are expressed in human and rat pancreatic islets and INS-1 cells. By application of either forskolin or 3-isobutyl-1-methylxanthine for 6 hours, calcium spiking was evoked and the release of insulin was increased. The expression of the calcium/calmodulin-dependent kinase IV and calcium/calmodulin-dependent kinase 2d transcripts was significantly increased due to forskolin or 3-isobutyl-1-methylxanthine. Acute melatonin treatment (6 h) in the presence of either forskolin or 3-isobutyl-1-methylxanthine caused a significant decrease in insulin release and induced significant downregulation of calcium/calmodulin-dependent kinase IV and calcium/calmodulin-dependent kinase 2d transcripts in INS-1 batch cultures. The attenuating effect of melatonin on transcripts could be almost completely reversed by preincubation with the melatonin receptor antagonist luzindole. Thus, the insulin-inhibiting effect of melatonin in INS-1 cells is associated with significant changes in transcripts of calcium-signaling components suggesting that melatonin influences gene expression of components, which are known to be involved in insulin secretion or insulin gene expression.
Design of multisine excitations to characterize the nonlinear distortions during FRF-measurements

In this paper multisine excitation signals are designed which will be used to detect and qualify the nonlinear distortions on FRF measurements, and this without making additional experiments. The kernel idea in this method is to apply well chosen periodic excitations where not all harmonics are excited. The nonexcited frequency lines are used to detect, qualify and quantify the nonlinear distortions, while the FRF is measured at the same time at the excited harmonics. Since not every multisine yields optimal results, this paper presents some signals by which the following purposes are accomplished: simplicity, robustness and a reliable nonlinear characterization.
WNT/Frizzled signalling: receptor–ligand selectivity with focus on FZD‐G protein signalling and its physiological relevance: IUPHAR Review 3

The wingless/int1 (WNT)/Frizzled (FZD) signalling pathway controls numerous cellular processes such as proliferation, differentiation, cell‐fate decisions, migration and plays a crucial role during embryonic development. Nineteen mammalian WNTs can bind to 10 FZDs thereby activating different downstream pathways such as WNT/β‐catenin, WNT/planar cell polarity and WNT/Ca2+. However, the mechanisms of signalling specification and the involvement of heterotrimeric G proteins are still unclear. Disturbances in the pathways can lead to various diseases ranging from cancer, inflammatory diseases to metabolic and neurological disorders. Due to the presence of seven‐transmembrane segments, evidence for coupling between FZDs and G proteins and substantial structural differences in class A, B or C GPCRs, FZDs were grouped separately in the IUPHAR GPCR database as the class FZD within the superfamily of GPCRs. Recently, important progress has been made pointing to a direct activation of G proteins after WNT stimulation. WNT/FZD and G protein coupling remain to be fully explored, although the basic observation supporting the nature of FZDs as GPCRs is compelling. Because the involvement of different (i) WNTs; (ii) FZDs; and (iii) intracellular binding partners could selectively affect signalling specification, in this review we present the current understanding of receptor/ligand selectivity of FZDs and WNTs. We pinpoint what is known about signalling specification and the physiological relevance of these interactions with special emphasis on FZD–G protein interactions.
Will Improvement in Quality of Life (QOL) Impact Fatigue in Patients Receiving Radiation Therapy for Advanced Cancer?

Background:Fatigue has a significant impact on the quality of life (QOL) of cancer patients. Recent research has suggested that physical activity can reduce fatigue in patients receiving active cancer treatment. In this project, we examined the impact that participation in a randomized controlled trial of a multidisciplinary intervention designed to impact overall QOL had on fatigue for advanced cancer patients actively receiving treatment. Methods:Patients with newly diagnosed cancer were randomly assigned to an 8-session structured multidisciplinary intervention or a standard-care arm at the beginning of their course of radiotherapy (RT) designed to impact QOL. Ninety-minute sessions were led by either a psychiatrist or psychologist, collaborating with a nurse, physical therapist, chaplain, or social worker, depending on the session's theme. The fatigue assessments used in this trial included the Linear Analogue Self Assessment (LASA), the Profile of Mood States (POMS), Spielberger's State-Trait Anxiety Inventory (STAI), and the Symptom Distress Scale (SDS). Results:There were 115 participants enrolled and the 2 randomization arms were well balanced in terms of baseline characteristics and treatment received except for increased commuting distance for the patients in the intervention arm (P = 0.042). Most of scores indicated less fatigue (higher score) in the standard treatment group, but there were no statistically significant differences found at baseline and weeks 4, 8, and 27 except for SDS at week 8 (P = 0.018) with less patients reporting significant fatigue in the standard treatment arm. For the entire participant population, fatigue levels initially worsened with radiotherapy, stabilized at week 8, and returned to baseline by week 27. Disease site, chemotherapy use, and radiotherapy dose did not have a significant impact on fatigue levels. Conclusions:Radiotherapy initially caused a worsening of fatigue but with time fatigue levels returned to baseline. Clinically, this structured multidisciplinary intervention had no impact on fatigue, and there was the suggestion the multiple sessions may have contributed to worse fatigue during active cancer treatment.