Miracle-dz/UniFAR-FTUs huggingface dataset:
ADVANCED JOURNAL OF EMERGENCY MEDICINE. 2019; 3(3): e22

Introduction: Acute kidney injury (AKI) is a common and devastating clinical issue in the community associated with high rates of morbidity and mortality. Objective: We aimed at estimating the frequency and levels of severity of AKI in trauma patients requiring hospital admission using the RIFLE criteria and assess their outcome. Method: Our retrospective record based study enrolled data of 80 participants aged 18-59 years who presented to the emergency department of KIMS hospital following an acute traumatic event. Participants with pre-existing renal dysfunction, chronic heart failure and chronic liver disease were excluded. Tests of significance were Chi square and independent sample t test, a p<0.05 was considered statistically significant. Results: Participants with AKI had significantly lower age (p=0.02) and lower revised trauma score (RTS) (p=0.01). Significant association of AKI with hypotension (p=0.01) and Glasgow coma scale (GCS) (p=0.008) was observed. No association of AKI with gender was observed (p=0.6). None of the AKI patients required renal replacement therapy and all participants attained normal renal function at discharge. Significantly longer mean duration of hospital stay (14.4 days) was observed among AKI patients (p=0.02). Totally, 6.3 % mortality was observed among both participants with and without AKI. Conclusion: Forty percent of acute trauma patients had AKI (in risk and injury category); but none were in failure, loss or end stage renal disease. No association of AKI and mortality was observed. AKI was associated with age, RTS, hypotension and GCS.
Evolution of the intermuscular bones in the Cyprinidae (Pisces) from a phylogenetic perspective

Abstract Intermuscular bones (IBs) are widely present in morphologically generalized teleost fishes and are commonly found in the Cyprinidae. Intermuscular bones are small, hard spicules of bone that are formed by ossification in the myosepta between neighboring myomeres. Why fish have IBs, and whether there is any evolutionary pattern to their occurrence, has been poorly understood. However, the presence of IBs does substantially affect the meat quality and commercial values of many cyprinid fishes in aquaculture. In this study, we sampled 592 individuals of cyprinid fishes to systematically investigate the evolution of IBs from a phylogenetic point of view. We found that the total number of IBs in the Cyprinidae ranged from 73 to 169, and we clarified that only two categories of IBs (epineural and epipleural) were present in all examined cyprinids. Most of the IBs were distributed in the posterior region of the fish, which might be an optimal target for selecting fewer IB strains in aquaculture. There was a positive correlation between IBs and the number of vertebrae, thus making it possible to predict the approximate number of IBs by counting the number of vertebrae. Although the IBs displayed some correlation with phylogenetic relationships in some lineages and to ecological factors such as diet (especially carnivore), in an overall view the variations of IBs in cyprinids were extremely diverse. The number and patterns of IBs in these fishes may reflect their phylogenetic history, but have been shaped by multiple environment factors. In this study, we also confirmed that X‐ray photography remains an optimal and reliable method for the study of IBs.
The effect of platelet lysate in culture of PDLSCs: an in vitro comparative study

Background Cellular therapy clinical applications require large-scale production of stem cells. Therefore, abundance, ease of isolation, and proliferative potential are the most important factors in choosing the appropriate source of cells for transplantation studies. Multipotent stem cells obtained from periodontal ligament (PDL) can be used in periodontal tissue regeneration. In this study, we aimed to evaluate and compare the characteristics of periodontal ligament stem cells (PDLSCs), extracted by either enzymatic digestion or explant methods, and expanded using two different serum types: fetal bovine serum (FBS) and xeno-free platelet lysate (PL). Methods Expanded PDLSCs were assessed for their proliferation capacity, surface markers expression, colony formation, differentiation potential and ability to self-renewal. Most importantly, PDLSCs were evaluated for their ability to produce osteoblasts in vitro. Results PDLSCs isolated by explant method and expanded in PL serve as a promising source of stem cells for osteoblasts regeneration. These cells showed higher proliferation capacity, they retained their stemness characteristics throughout the passages and they revealed an increase in the expression level of osteogenic markers, without showing any karyotypic abnormalities after cell expansion. Conclusions PDLSCs produced using explant extraction method and expanded in cell culture media supplemented with PL provide an excellent source of xeno-free cells for the generation of functional osteoblasts.
Is reproductive strategy a key factor in understanding the evolutionary history of Southern Ocean Asteroidea (Echinodermata)?

Abstract Life traits such as reproductive strategy can be determining factors of species evolutionary history and explain the resulting diversity patterns. This can be investigated using phylogeographic analyses of genetic units. In this work, the genetic structure of five asteroid genera with contrasting reproductive strategies (brooding: Diplasterias, Notasterias and Lysasterias versus broadcasting: Psilaster and Bathybiaster) was investigated in the Southern Ocean. Over 1,400 mtDNA cytochrome C oxidase subunit I (COI) sequences were analysed using five species delineation methods (ABGD, ASAP, mPTP, sGMYC and mGMYC), two phylogenetic reconstructions (ML and BA), and molecular clock calibrations, in order to examine the weight of reproductive strategy in the observed differences among phylogeographic patterns. We hypothesised that brooding species would show higher levels of genetic diversity and species richness along with a clearer geographic structuring than broadcasting species. In contrast, genetic diversity and species richness were not found to be significantly different between brooders and broadcasters, but broadcasters are less spatially structured than brooders supporting our initial hypothesis and suggesting more complex evolutionary histories associated to this reproductive strategy. Broadcasters' phylogeography can be explained by different scenarios including deep‐sea colonisation routes, bipolarity or cosmopolitanism, and sub‐Antarctic emergence for the genus Bathybiaster; Antarctic‐ New Zealand faunal exchanges across the Polar Front for the genus Psilaster. Brooders' phylogeography could support the previously formulated hypothesis of a past trans‐Antarctic seaway established between the Ross and the Weddell seas during the Plio‐Pleistocene. Our results also show, for the first time, that the Weddell Sea is populated by a mixed asteroid fauna originating from both the East and West Antarctic.
MRP4 sustains Wnt/β-catenin signaling for pregnancy, endometriosis and endometrial cancer

Rationale: Abnormal Wnt/β-catenin signaling in the endometrium can lead to both embryo implantation failure and severe pathogenic changes of the endometrium such as endometrial cancer and endometriosis. However, how Wnt/β-catenin signaling is regulated in the endometrium remains elusive. We explored possible regulation of Wnt/β-catenin signaling by multi-drug resistance protein 4 (MRP4), a potential target in cancer chemotherapy, and investigated the mechanism. Methods: Knockdown of MRP4 was performed in human endometrial cells in vitro or in a mouse embryo-implantation model in vivo. Immunoprecipitation, immunoblotting and immunofluorescence were used to assess protein interaction and stability. Wnt/β-catenin signaling was assessed by TOPflash reporter assay and quantitative PCR array. Normal and endometriotic human endometrial tissues were examined. Data from human microarray or RNAseq databases of more than 100 participants with endometriosis, endometrial cancer or IVF were analyzed. In vitro and in vivo tumorigenesis was performed. Results: MRP4-knockdown, but not its transporter-function-inhibition, accelerates β-catenin degradation in human endometrial cells. MRP4 and β-catenin are co-localized and co-immunoprecipitated in mouse and human endometrium. MRP4-knockdown in mouse uterus reduces β-catenin levels, downregulates a series of Wnt/β-catenin target genes and impairs embryo implantation, which are all reversed by blocking β-catenin degradation. Analysis of human endometrial biopsy samples and available databases reveals significant and positive correlations of MRP4 with β-catenin and Wnt/β-catenin target genes in the receptive endometrium in IVF, ectopic endometriotic lesions and endometrial cancers. Knockdown of MRP4 also inhibits in vitro and in vivo endometrial tumorigenesis. Conclusion: A previously undefined role of MRP4 in stabilizing β-catenin to sustain Wnt/β-catenin signaling in endometrial cells is revealed for both embryo implantation and endometrial disorders, suggesting MRP4 as a theranostic target for endometrial diseases associated with Wnt/β-catenin signaling abnormality.
Antifungal effects of indolicidin-conjugated gold nanoparticles against fluconazole-resistant strains of Candida albicans isolated from patients with burn infection

Background: Candida albicans as an opportunistic fungus is one of the most important causes of late-onset morbidity and mortality in patients with major burns and severely impaired immune system. In recent years, the emergence of resistance to opportunistic fungi and toxicity of antimicrobial drugs make it necessary to develop new drugs. Methods: In the present study, we investigated anticandidal effects of indolicidin, as a representative of host defense peptide, conjugated with gold nanoparticles in fluconazole-resistant clinical isolates of C. albicans. After characterizing the conjugation of indolicidin using biophysical methodologies, the cytotoxicity and hemolytic activity of the nanocomplex were examined. In addition, the expression level of ERG11, responsible for antifungal resistance, and the immunomodulatory effect of peptide-nanomaterial conjugates were assessed. Results: Our data indicated that the nanocomplex was nontoxic for the fibroblast cells and erythrocytes. Treatment with the nanocomplex significantly reduced the expression levels of the ERG11 gene in fluconazole-resistant C. albicans isolates and the iNOS gene in macrophages. Conclusion: The study data provides a chance to develop innovative therapies for the treatment of C. albicans burn infections. However, further investigation is required to examine the efficiency of the nanocomplex.
Nitrogen addition decreases seed germination in a temperate steppe

Abstract Seed germination and seedling establishment play an important role in driving the responses of plant community structure and function to global change. Nitrogen (N) deposition is one of the driving factors of global change, which often leads to a loss in species richness in grassland ecosystems. However, how seed germination responds to N addition remains unclear. A pot incubation test was conducted in a semi‐arid grassland in the Mongolian Plateau, Northern China, to investigate the effect of N addition (0, 5, 10, 20, 40, and 80 g N/m2) on seed germination from May to October 2016. Twenty species germinated under all treatments; however, the responses of the 20 species to N addition were different. The densities of Stipa krylovii, Leymus chinensis, and Artemisia frigida, which are the dominant species in this temperate steppe, decreased significantly as the amount of N addition. Moreover, N addition significantly suppressed seedling densities of the community, perennial forbs, perennial grasses, and annuals and biennials. Furthermore, species richness of the community, perennial forbs, and annuals and biennials decreased sharply with increasing N addition level, but perennial grass species richness did not change. The Shannon–Wiener diversity index also decreased as the amount of N addition increased. Our results suggest that N enrichment plays an important role in the seed germination stage and decreases supplements of seedlings to adult plants. These findings may help explain the causes of species loss by atmospheric N deposition in grassland ecosystems.
Association between motor competence and Functional Movement Screen scores

Background Motor competence (MC) is generally used to describe a person’s proficiency in a variety of motor skills and is the basis for one’s performance in sports and recreational activities. Functional Movement Screen (FMSTM) is one of the most used screening systems to provide interpretable measure of movement quality. Both FMSTM and MC constructs share three components: locomotor, manipulative and stabilizing movements. In the present study, it was hypothesized that MC scores can explain FMSTM variables. It was also predicted that better MC leads to better functional movement patterns in young adults. Methods A sample of 92 young adults (73.9% men) with a mean age of 21.2 years participated in this study. All participants were evaluated on anthropometric measurements, dual x-ray absorptiometry; FMSTM and MC. Results Men showed better MC scores and fat mass composition than women. Regarding specific tests, women scored higher in the FMSTMactive straight leg raise test, whereas men performed better in the FMSTM trunk stability push-up (TSP) test. Manipulative tasks and construct presents’ significant and positive associations with FMSTM composite score (r ≥ 0.303). The significant negative correlation were more related to FMSTM TSP and MC shuttle run and FMSTM in-line lunge and MC manipulative. The FMSTM TSP presents significant associations with all MC constructs and tasks. Meanwhile, the FMSTM composite score is associated with all components of MC Stability (p < 0.05). In young adults, and independent of gender, the FMSTMexplains fundamental movements based on motor control according to the stability construct. Moreover, the FMSTM TSP is associated with better performance in the all MC constructs and MC tasks. The FMSTM, on its own, is linked to objective MC stability measures.
Performance Analysis of Adaptive Fuzzy Spray and Wait Routing Protocol

—Delay Tolerant networks (DTN) are Ad-hoc mobile networks that aim to avoid traditional Internet limitations in difficult environments that are identified by intermittent connectivity, power outages, and difficult topographies by following the Store-Carry-and-Forward mechanism. In the present work, we are comparing Adaptive Fuzzy Spray and Wait routing protocol to other famous DTN routing protocols in terms of delivery rate, overhead ratio and latency average. During the simulations we are analyzing the impact of changing nodes buffer sizes and a bunch of DTN drop policies on the above metrics.
An Enhanced University Registration Model Using Distributed Database Schema

A big database utilizes the establishing network technology, and it became an emerging trend in the computing field. Therefore, there is a necessity for an optimal and effective data distribution approach to deal with this trend. This research presents the practical perspective of designing and implementing distributed database features. The proposed system has been establishing the satisfying, reliable, scalable, and standardized use of information. Furthermore, the proposed scheme reduces the vast and recurring efforts for designing an individual system for each university, as well as it is effectively participating in solving the course equivalence problem. The empirical finding in this study shows the superiority of the distributed system performance based on the average response time and the average waiting time than the centralized system. The system throughput also overcomes the centralized system because of data distribution and replication. Therefore, the analyzed data shows that the centralized system thrashes when the workload exceeds 60%, while the distributed system becomes thrashes after 81% workload.
Reaching Byzantine Agreement underlying VANET

The Internet of Things (IoT) enables machines and devices in a global network to connect and provide applications. The Vehicular Ad-hoc NETwork (VANET) allows vehicles in the network to communicate with each other as an application of the IoT. The safety and comfort of passengers can be improved through VANET related applications. In order to be able to provide related applications, there must be a reliable VANET topology. As a result of the Byzantine agreement (BA), fault tolerance can be solved in VANET. In order to improve the reliability of the system, even if some components in the system are damaged, a protocol is needed to assist the system to perform normally. Therefore, the BA problem in VANET with multiple impairments is revisited in this research. The proposed protocol allows all normal processing elements (PEs) to reach agreement using the least amount of information exchange. Moreover, the proposed protocol can tolerate the largest number of damaged PEs in VANET.
A multi-objective multi-factorial evolutionary algorithm with reference-point-based approach

In recent years, multi-task optimization is one of the emerging topics among evolutionary computation researchers. Multi-Factorial Evolutionary Algorithm (MFEA) is developed based on that individuals, from various cultures, exchange their underlying similarities to improve the convergence characteristic. However, in terms of Multi-Objective Multi-Factorial Optimization (MOMFO), current algorithms employing nondominated front ranking and crowding distance still meet difficulties when the number of objective functions arises. In this paper, we propose a Muli-Objective Multi-Factorial Evolutionary Algorithm (MO-MFEA) with reference-point-based approach to improve the multitasking framework. Rather than using crowding distance to compute individual ranking in the context of MOMFO, we employ a set of reference points to determine the diversity of current population. On the other hand, we improve the guided method that automatically adapt the Random Mating Probability (RMP) in order to exploit shared knowledge among high similar task. Further improvement on genetic operators with JADE crossover and NSLS. The conducted experiments demonstrate our approach performs better than the baseline results.
Turbidite sedimentology, biostratigraphy and paleoecology: A case study from the Oligocene Zuberec Fm. (Liptov Basin, Central Western Carpathians)

Abstract Outcrops of a thick turbiditic succession are exposed on the northern bank of the Liptovská Mara reservoir near Liptovská Ondrašová and Ráztoky. The section consists of rhythmic, predominantly thin- to medium-bedded turbidites of the Rupelian age. Their biostratigraphy is based on the calcareous nannofossils. Facies associations of these deposits represent different components of depositional lobe deposits in the turbidity fan system, including mainly the lobe fringe and lobe distal fringe/inter-lobe facies associations and locally the medium bedded deposits of the lobe off-axis facies association. This interpretation is supported by statistical analysis. The deep-sea turbiditic deposits contain trace fossil associations, which include deep-tier fodinichnia and domichnia up to shallow-tier graphoglyptids. Paleocurrent measurements indicate that the majority of sedimentary material was transported from SW and W.
Natural Search User Interfaces for Complex Biomedical Search: An Eye Tracking Study

Abstract Controlled vocabularies such as Medical Subject Headings (MeSH) have been extensively used to organise information resources in the biomedical domain. However, the usefulness of these terms for information access has not been rigorously evaluated in interactive search environments. The objective of this study was to gain an understanding of domain experts’ interactions with novel search interfaces within the context of biomedical information search, with a goal of better interface design of information retrieval systems. An eye tracking study of biomedical domain experts’ interactions with novel search interfaces was conducted, considering user’s individual differences and gaze behaviour. The findings suggest that types of search interfaces have significant effects on gaze behaviour in terms of fixation-based measures of areas of interest, i.e. visual attention to the elements of title, author, abstract and MeSH terms in document surrogates. Significant interaction effects between cognitive style and user interaction with search interfaces were found, specifically the amount of attention to MeSH terms by analytic and wholistic searchers. These findings contribute to our understanding of the relationship between cognitive styles and gaze patterns in information search. Based on these findings, the implications of individual differences and gaze behaviour for search interface design are discussed.
Evaluating 3-D and 1-D mathematical models for mass transport in heterogeneous biofilms

Results from a three dimensional model for heterogeneous biofilms including the numerical solution of hydrodynamics were compared to simplified one dimensional models. A one dimensional model with a variable diffusion coefficient over the thickness of the biofilm was well suited to approximate average concentration profiles of three dimensional simulations of rough biofilms. A new compartmentalized one dimensional model is presented that is then used to evaluate effects of pores and channels on microbial competition in heterogeneous biofilms. Surface and pore regions of the biofilm are modeled using separate compartments coupled by a convective link. Local concentration profiles from the three dimensional simulations could be adequately reproduced using the compartmentalized one dimensional model. The compartmentalized one dimensional model was then used to evaluate bacterial competition in a growing biofilm and in a mushroom type biofilm assuming different modes of detachment.
Dualität in der Funktionentheorie.

Einleitung. Kürzlich hat J. S. e Silva ([13], [14]) ) eine interessante neue Grundlegung der Theorie der analytischen Funktionale von L. Fantappie ) gegeben. Sein Ausgangspunkt ist der lineare Raum JR(2l) aller auf einer abgeschlossenen echten Teilmenge 9l der Riemannschen Zahlenkugel lokalanalytischen Funktionen u ( ). Ein solches u ( ) ist eine in einer offenen Sl enthaltenden Punktmenge erklärte und dort differenzierbare Funktion, und zwei solche ( ) , die auf dem Durchschnitt ihrer Defmitionsbereiche übereinstimmen, sind als äquivalent anzusehen. Ferner wird vorausgesetzt, daß u in oo verschwindet", falls oo in 9l liegt. In . fi(Sl) ist durch die gleichmäßige Konvergenz auf einer geeigneten, 31 umfassenden offenen Menge eine Konvergenz eingeführt. Die linearen analytischen Funktionale und die analytischen Linien von Fantappie lassen sich dann deuten als stetige lineare Abbildungen dieser Räume J? (2l). Es gelang Silva in [14] nicht, eine einfache Topologie in J? (9l) einzuführen, die den angegebenen Konvergenzbegriff liefert, und so blieb die Einordnung in die allgemeine Theorie der linearen Räume noch zu leisten. Silva bewies, daß /? (2l) kein Banachscher Raum sein kann. In einem Spezialfall, nämlich 9l gleich einem Punkt oder einer Kreisscheibe, hatte 0. Toeplitz [15] mit den Mitteln der Theorie der vollkommenen Räume den Raum J? (9l) ebenfalls untersucht, eine einfache Topologie in ihm eingeführt und auch den dazu dualen Raum bestimmt. Für den allgemeinen Fall reicht die Theorie der vollkommenen Räume nicht aus ; nach den Ergebnissen von Toeplitz war aber anzunehmen, daß die Theorie der Räume vom Typus (F) von J. Dieudonno und L. Schwartz [3] das geeignete Hilfsmittel sein würde. Es ist naheliegender, vom dualen Raum zu R (9l) auszugehen. Ist © ein echtes Teilgebiet von JÖ, so bezeichne JP(@) den linearen Raum aller in © erklärten und dort analytischen Funktionen, die im Punkt oo verschwinden, falls er zu 6J gehört. Ist ©^©gc:. eine Folge abgeschlossener Gebiete mit der Vereinigung ©, so wird durch die Normen || x(z) ||n = sup l x(z) l, n = 1,2, . ,