Miracle-dz/UniFAR-FTUs huggingface dataset:
NK1 receptor antagonism and emotional processing in healthy volunteers

The neurokinin-1 (NK 1) receptor antagonist, aprepitant, showed activity in several animal models of depression; however, its efficacy in clinical trials was disappointing. There is little knowledge of the role of NK1 receptors in human emotional behaviour to help explain this discrepancy. The aim of the current study was to assess the effects of a single oral dose of aprepitant (125 mg) on models of emotional processing sensitive to conventional antidepressant drug administration in 38 healthy volunteers, randomly allocated to receive aprepitant or placebo in a between groups double blind design. Performance on measures of facial expression recognition, emotional categorisation, memory and attentional visual-probe were assessed following the drug absorption. Relative to placebo, aprepitant improved recognition of happy facial expressions and increased vigilance to emotional information in the unmasked condition of the visual probe task. In contrast, aprepitant impaired emotional memory and slowed responses in the facial expression recognition task suggesting possible deleterious effects on cognition. These results suggest that while antagonism of NK1 receptors does affect emotional processing in humans, its effects are more restricted and less consistent across tasks than those of conventional antidepressants. Human models of emotional processing may provide a useful means of assessing the likely therapeutic potential of new treatments for depression.
ANALISIS PENGARUH TOTAL ASSET, FUND AGE, EXPENSE RATIO DAN PORTOFOLIO TURNOVER TERHADAP KINERJA REKSA DANA(Studi Kasus: Reksa Dana Konvensional Berbasis KIK Tahun 2012-2014)

Mutual fund An investment vehicle that is made up of a pool of funds collected from many investors for the purpose of investing in securities such as stocks, bonds, money market instruments and similar assets. Mutual funds are Managed by an professional investmen maganer that can manage the fund in accordance with its investmen objectives. The method used is multiple regression analysis with the classical assumption as statistical requirements. The research variables consisted of total assets, fund age, expense ratio and portfolio turnover. Data used in the study include the NAB monthly data, the effective date of mutual funds, expense ratio and portfolio turnover in the period 2012 - 2014. Forty-five conventional mutual funds with the observation period of 3 years cover 15 equity funds, 15 fixed income funds and 15 mixed fund. The result show that in a simultaneous manner fund characteristics total asset , fund age, expense ratio and portofolio turnover have influence in the amount of 24,4%. The partial test showed that fund total asset and expense ratio give a positive effect and significant on the performance of conventional mutual fund. Portofolio turnover give a negative effect and not significant on the performance of mutual fund. Fund age give a positif effect but not significant on the performance of mutual fund.
A population-based family study of DSM-III generalized anxiety disorder

Background. A recent meta-analysis provides evidence that generalized anxiety disorder (GAD) is familial. However, two of the key studies relied on subjects who were self-selected or recruited from the clinic setting, thereby limiting generalizability. Method. We conducted a family study of GAD in which probands and controls came from a community sample originally enrolled in a prevalence study in Edmonton, Canada. One hundred and sixty probands, 764 controls and 2386 first-degree relatives (FDRs) were interviewed using the Diagnostic Interview Schedule (DIS); lifetime diagnoses were made according to DSM-III criteria without exclusions. Logistic regression analysis was performed with GAD (in a proband) as the ‘exposure’, and GAD in an FDR as the ‘outcome’. Several analytic strategies were used to control for potential confounding by major depressive disorder (MDD) and several anxiety disorders (panic disorder, phobic disorders, obsessive–compulsive disorder, and post-traumatic stress disorder). Results. The odds ratios for the association between GAD in a proband and GAD in an FDR were in the range 1·4–1·8 when the entire FDR sample was analysed, and in the range 2·1–2·8 when we restricted to FDRs who were children of probands and controls. Conclusion. In the community setting, GAD exhibits mild to moderate familial aggregation.
Are Discretionary Accruals Signal for the Bright Future? Evidence from Information Demand and Supply Matrix

Two competing hypotheses explain the motivation of using discretionary accruals: managerial opportunism and managerial optimism. To the extent of managerial optimism hypothesis, the purpose of my study is to examine whether managers use discretionary accruals to disseminate their private information when the information demand of stakeholders is high while information supply is low. If market participants cannot access sufficient information about a firm, they are likely to make wrong decisions or to postpone making their decisions. If this is the case, managers will attempt to spread their private and optimistic forecasts through discretionary accruals in order to facilitate proper decision making of market participants. Consistent with my predictions, I find:(1) managers tend to use more discretionary accruals when the information demand is high while the information supply is low, (2) and the discretionary accruals contain favorable signals about the future performance.
Contributions to the binding, two-loop correction to the Lamb shift.

In this paper I present an evaluation of the two-loop diagrams, including the closed electron loop, which contribute to the Lamb shift in ([alpha]/[pi])[sup 2]([ital Z][alpha])[sup 5]/[ital n][sup 3] order. These corrections sum to 2.710 61(1) for [ital S] states, which gives a 37.41-kHz shift for the 1[ital S] state of the hydrogen atom.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI KINERJA KEUANGAN PERUSAHAAN TELEKOMUNIKASI YANG GO PUBLIC DI BURSA EFEK INDONESIA

This research is held to find out the following factors: current ratio, total asset turnover, working capital turnover, debt to equity ratio, debt ratio, and net profit margin toward the return on investment of the go-public telecommunication in Bursa Efek Indonesia. This research is an explanation research with descriptive statistics and inferential analysis in the form of classic assumption test and multi regression to analyze the research data. From the result of simultaneously test that current ratio, total asset turnover, working capital turnover, debt to equity ratio, debt ratio, and net profit margin had influence towards return on investment. The six independent variables can explain the dependent variables of 93,7% while the 6,3% influence by the other variable that was not include in this research. Partially, only total asset turnover and net profit margin that influence return on investment, while current ratio, working capital turnover, debt to equity ratio, debt ratio were not influence return on investment. Net profit margin was the most dominant variable that influence return on investment, because it had partial correlation value of (0,755) and t was the biggest (4,887). Telecommunication company should not only focused on company liquidity, although many investors rate the financial work from how much the liquidity value of a company, but how much company liquidity gave not good influence towards company profitability because it showed how many investorrs funds that not take advantage rightly by the company, because of that company must be optimal in using investorrs funds to make maximal return. Beside, laverage of telecommunication companies also gave not good risk towards company profitability. It also with the company activity in using asset, within the increase of company asset it should be increase in asset value or return obtained by increased asset value. The policy that telecommunication company should have was be focused in net profit margin because its influence was dominant towards financial work. Without prejudice attention to total asset turnover because to keep both of variables balance means it also can keep financial work in company.
Elevation protective role of Camellia sinensis and Urtica dioica infusion against trichloroacetic acid‐exposed in rats

This study was designed to investigate the protective effects of two traditionally used Turkish medicinal plants, Camellia sinensis (CS) and Urtica dioica L. (UD), beverages used against chemical carcinogen trichloroacetic acid (TCA)‐exposure in rats. The preventive potential of the plant infusions was evaluated by measuring the level of serum marker enzymes, aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatine phosphokinase (CPK), acid phosphatase (ACP), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH); antioxidant defense systems, reduced glutathione (GSH), glutathione reductase (GR), superoxide dismutase (SOD), glutathione‐S‐transferase (GST) and catalase (CAT); and lipid peroxidation (malondialdehyde, MDA) content in various organs of rats. Twenty four healthy rats were randomly allotted into four experimental groups: A (untreated control), B (only TCA‐treated), C (TCA + CS treated) and D (TCA + UD treated). At the end of the 50 days, the plant infusions possessed chemoprotective effects, deduced by the remaining TCA‐induced increased serum damage marker enzyme, lipid peroxidation and antioxidative system in rats compared with those of the control and TCA‐exposed rats. According to the results, while the levels of AST, ALT and CPK increased in group B, no significant changes were observed in groups C and D. The MDA content slightly increased in tissues of all groups, being higher in group B. Antioxidant enzyme activities such as SOD and CAT increased significantly in the brain, liver and kidney of group B while they did not change significantly except for in the kidney in groups C and D. The GSH level and the ancillary enzyme GR activity did not change significantly in organs of all groups. On the other hand, the drug metabolizing enzyme, GST, activity decreased significantly in the brain, liver and kidney of group D while slight changes were observed for the other groups. The results revealed that TCA exposure induced oxidative stress in rat tissues, however, in plant beverage supplemented groups, a significant protective effect of CS and UD against TCA‐induced oxidative injury was recorded. Hence, the study revealed that the constituents present in CS and UD impart protection against carcinogenic chemical induced oxidative injury that may result in the development of cancer. Also the observations, along with changes, suggest that both CS and UD may possess preventive potential during a 50‐day protective exposure. Copyright © 2007 John Wiley & Sons, Ltd.
Esophagitis and cancer of the esophagus

Early diagnosis is an important factor in the effort to increase the healing rates of esophageal cancer; another consideration is the establishment of a reliable method of identifying risk groups. Alcohol abuse is known to be associated with a higher risk of esophageal cancer. The current investigation, based on a retrospective study of the records of patients with esophageal cancer, reveals a strong connection between cancer development and chronic esophagitis due mainly to reflux in about 10% of the patients. In the literature this connection has been suspected but never so clearly shown. The clinical implication may be a more rigorous approach to long‐standing esophagitis in elderly patients.
After the Genocide: Psychological Perspectives on Victim, Bystander, and Perpetrator Groups

Interest in the aftermath of genocide and mass violence has increased in the last few years, and some researchers in various subdisciplines of psychology have begun to address this urgent social issue. Genocide and mass violence continue to influence intergroup relations, conflicts, and policy attitudes. Nevertheless, these topics are still understudied. We introduce this issue by providing a brief overview of the scarce psychological research on the aftermath of genocide among members of former victim, perpetrator, and bystander groups. Although this distinction is too simplistic to explain individual behavior during genocide and its aftermath, we hold on to it as a framework for organizing existing scholarship, and because of the ongoing relevance of these social representations in discourse on this topic. The introduction concludes with an overview of the issue and its organization, including a brief summary of each article.
CD163+ Tumor-Associated Macrophages Correlated with Poor Prognosis and Cancer Stem Cells in Oral Squamous Cell Carcinoma

Tumor-associated macrophages (TAMs) play an important role in the progression and prognostication of numerous cancers. However, the role and clinical significance of TAM markers in oral squamous cell carcinoma (OSCC) has not been elucidated. The present study was designed to investigate the correlation between the expression of TAM markers and pathological features in OSCC by tissue microarray. Tissue microarrays containing 16 normal oral mucosa, 6 oral epithelial dysplasia, and 43 OSCC specimens were studied by immunohistochemistry. We observed that the protein expression of the TAM markers CD68 and CD163 as well as the cancer stem cell (CSC) markers ALDH1, CD44, and SOX2 increased successively from the normal oral mucosa to OSCC. The expressions of CD68 and CD163 were significantly associated with lymph node status, and SOX2 was significantly correlated with pathological grade and lymph node status, whereas ALDH1 was correlated with tumor stage. Furthermore, CD68 was significantly correlated with CD163, SOX2, and ALDH1 (P < 0.05). Kaplan-Meier analysis revealed that OSCC patients overexpressing CD163 had significantly worse overall survival (P < 0.05). TAM markers are associated with cancer stem cell marker and OSCC overall survival, suggesting their potential prognostic value in OSCC.
Economic well-being of disabled elderly living in the community

This study focuses on understanding the economic well-being of a growing subgroup of elderly, noninstitutionalized elderly facing risks of health problems and financial dependency. The combination of predisposing characteristics and resources that best explain differences in economic well-being of elderly was examined using a sample from the 1984 National Long Term Care Survey of elderly with functional limitations living in the community (N=5500). There were significant differences in economic well-being by age, marital status, gender, race, types of income sources and education, although age, race and gender did not have significant effects when other variables were controlled. Resource variables added the most explanation for differences in economic well-being, especially sources of income beyond Social Security. The results show the importance of having retirement income sources beyond Social Security for preventing poverty in retirement.
Anticancer effects of ZD6474, a VEGF receptor tyrosine kinase inhibitor, in gefitinib (“Iressa”)‐sensitive and resistant xenograft models

ZD6474 is a novel, orally available inhibitor of vascular endothelial growth factor (VEGF) receptor‐2 (KDR) tyrosine kinase, with additional activity against epidermal growth factor receptor (EGFR) tyrosine kinase. ZD6474 has been shown to inhibit angiogenesis and tumor growth in a range of tumor models. Gefitinib (“Iressa”) is an selective EGFR tyrosine kinase inhibitor (TKI) that blocks signal transduction pathways. We examined the antitumor activity of ZD6474 in the gefitinib‐sensitive lung adenocarcinoma cell line, PC‐9, and a gefitinib‐resistant variant (PC‐9/ZD). PC‐9/ZD cells showed cross‐resistance to ZD6474 in an in vitro dye formation assay. In addition, ZD6474 showed dose‐dependent inhibition of EGFR phosphorylation in PC‐9 cells, but inhibition was only partial in PC‐9/ZD cells. ZD6474‐mediated inhibition of tyrosine residue phosphorylation (Tyr992 and Tyr1045) on EGFR was greater in PC‐9 cells than in PC‐9/ZD cells. These findings suggest that the inhibition of EGFR phosphorylation by ZD6474 can contribute a significant, direct growth‐inhibitory effect in tumor cell lines dependent on EGFR signaling for growth and/or survival. The effect of ZD6474 (12.5–50 mg/kg/day p.o. for 21 days) on the growth of PC‐9 and PC‐9/ZD tumor xenografts in athymic mice was also investigated. The greatest effect was seen in gefitinib‐sensitive PC‐9 tumors, where ZD6474 treatment (>12.5 mg/kg/day) resulted in tumor regression. Dose‐dependent growth inhibition, but not tumor regression, was seen in ZD6474‐treated PC‐9/ZD tumors. These studies demonstrate that the additional EGFR TKI activity may contribute significantly to the anti‐tumor efficacy of ZD6474, in particular in those tumors that are dependent on continued EGFR‐signaling for proliferation or survival. In addition, these results provide a preclinical rationale for further investigation of ZD6474 as a potential treatment option for both EGFR‐TKI‐sensitive and EGFR‐TKI‐resistant tumors.
1 CHRISTIAN-MUSLIM FERTILITY DIFFERENCES IN POOR SETTINGS IN GREATER BEIRUT , LEBANON

In this paper, we examine differentials in fertility between Christians and Muslims in three poor communities in Greater Beirut, Lebanon using data from the 2002 – 2003 Urban Health Survey. The difference in total marital fertility rate between Christians and Muslims in these poor settings is very substantial (3.71 and 5.95 respectively). Surprisingly, the total fertility rate of Christians is well below replacement level (1.74). Results from the adjusted parity progression ratios show that young Christian and Muslim women are significantly less likely to progress to the next parity than their older counterparts. However, fertility decline among Christians is much more significant and has been underway for sometime, while that among Muslim women is a recent phenomenon. The decline in Muslim fertility – especially at parities three, four and five – seems to coincide with the end of the civil war in the early 1990’s, while that of Christians is at least 10 years earlier. The differences in marital fertility by religious affiliation persist after controlling for differences in socio-economic conditions, religiosity, and cultural capital. We discuss other – context-specific – explanations of the religious fertility differences taking into account Lebanon’s social, economic, historic and
ontribution of Methylenetetrahydrofolate Reductase MTHFR ) Polymorphisms to Negative Symptoms n Schizophrenia

esults: The 677T allele load was associated with negative symptom severity. Contrary to our expectations, the T allele was also found to be rotective against positive symptoms. The A1298C polymorphism did not contribute to negative symptoms, and only weakly to positive ymptoms. The specific effects of the C677T polymorphism were confirmed with haplotype analysis. Among patients homozygous for the 67T allele, serum folate levels correlated with negative symptom severity.
Efficacy of Lisdexamfetamine in Adults With Moderate to Severe Binge-Eating Disorder: A Randomized Clinical Trial

Importance The ability of pharmacotherapies to prevent relapse and maintain efficacy with long-term treatment in psychiatric conditions is important. Objective To assess lisdexamfetamine dimesylate maintenance of efficacy in adults with moderate to severe binge-eating disorder. Design, Setting, and Participants A multinational, phase 3, double-blind, placebo-controlled, randomized withdrawal study including 418 participants was conducted at 49 clinical research study sites from January 27, 2014, to April 8, 2015. Eligible adults met DSM-IV-R binge-eating disorder criteria and had moderate to severe binge eating disorder (≥3 binge-eating days per week for 14 days before open-label baseline; Clinical Global Impressions−Severity [CGI-S] scores ≥4 [moderate severity] at screening and open-label baseline). Following a 12-week, open-label phase (dose optimization, 4 weeks [lisdexamfetamine dimesylate, 50 or 70 mg]; dose maintenance, 8 weeks), lisdexamfetamine responders (⩽1 binge eating day per week for 4 consecutive weeks and CGI-S scores ⩽2 at week 12) were randomized to placebo or continued lisdexamfetamine during a 26-week, double-blind, randomized withdrawal phase. Interventions Lisdexamfetamine administration. Main Outcomes and Measures The primary outcome variable, time to relapse (≥2 binge-eating days per week for 2 consecutive weeks and ≥2-point CGI-S score increases from randomized withdrawal baseline), was analyzed using a log-rank test (primary analysis); the analysis was stratified for dichotomized 4-week cessation status. Safety assessments included treatment-emergent adverse events. Results Of the 418 participants enrolled in the open-label phase of the study, 411 (358 [87.1%] women; mean [SD] age, 38.3 [10.4] years) were included in the safety analysis set. Of 275 randomized lisdexamfetamine responders (placebo, n = 138; lisdexamfetamine, n = 137), the observed proportions of participants meeting relapse criteria were 3.7% (5 of 136) for lisdexamfetamine and 32.1% (42 of 131) for placebo. Lisdexamfetamine demonstrated superiority over placebo on the log-rank test (&khgr;21, 40.37; P < .001) for time to relapse; the hazard ratio, based on a Cox proportional hazards model for lisdexamfetamine vs placebo, was 0.09 (95% CI, 0.04-0.23). The treatment-emergent adverse events observed were generally consistent with the known profile of lisdexamfetamine. Conclusions and Relevance Risk of binge-eating relapse over 6 months was lower in participants continuing lisdexamfetamine than in those randomized to placebo. The hazard for relapse was lower with lisdexamfetamine than placebo. Trial Registration clinicaltrials.gov Identifier: NCT02009163
Structure, subunit composition, and molecular weight of RD-114 RNA

The properties and subunit composition of the RNA extracted from RD-114 virions have been studied. The RNA extracted from the virion has a sedimentation coefficient of 52S in a nondenaturing aqueous electrolyte. The estimated molecular weight by sedimentation in nondenaturing and weakly denaturing media is in the range 5.7 X 10(6) to 7.0 X 10(6). By electron microscopy, under moderately denaturing conditions, the 52S molecule is seen to be an extended single strand with a contour length of about 4.0 mum corresponding to a molecular weight of 5.74 X 10(6). It contains two characteristic secondary structure features: (i) a central Y- or T-shaped structure (the rabbit ears) with a molecular weight of 0.3 X 10(6), (ii) two symmetreically disposed loops on each side of and at equal distance from the center. The 52S molecule consists of two half-size molecules, with molecular weight 2.8 X 10(6), joined together within the central rabbit ears feature. Melting of the rabbit ears with concomitant dissociation of the 52S molecule into subunits, has been caused by either one of two strongly denaturing treatments: incubation in a mixture of CH3HgOH and glyoxal at room temperature, or thermal dissociation in a urea-formamide solvent. When half-size molecules are quenched from denaturing temperatures, a new off-center secondary structure feature termed the branch-like structure is seen. The dissociation behavior of the 52S complex and the molecular weight of the subunits have been confirmed by gel electrophoresis studies. The loop structures melt at fairly low temperatures; the dissociation of the 52S molecule into its two subunits occurs at a higher temperature corresponding to a base composition of about 63% guanosine plus cytosine. Polyadenylic acid mapping by electron microscopy shows that the 52S molecule contains two polyadenylic acid segments, one at each end. It thus appears that 52S RD-114 RNA consists of two 2.8 X 10(6) dalton subunits, each with a characteristic secondary structure loop, and joined at the 5' ends to form the rabbit ears secondary structure feature. The observations are consistent with but do not require the conclusion that the two 2.8 X 10(6) dalton subunits of 52S RD-114 RNA are identical.