Miracle-dz/UniFAR-FTUs huggingface dataset:
Long-term evaluation of the clinical effectiveness of community milk fluoridation in Bulgaria.

OBJECTIVE To determine the clinical effectiveness of a community milk fluoridation programme. BASIC RESEARCH DESIGN Parallel arm 5-year cohort study, with final cross-sectional comparisons between groups. PARTICIPANTS 3-year-olds in 8 Bulgarian cities/towns entered the cohort study with random samples (n = 1,782) recruited at baseline in 2004. After 5 years in 2009 sub-samples (about 30%) of these now aged 8 were randomly selected in intervention sites for follow-up examination (n = 454); 276 controls were examined at the age 8 years. For cross-sectional comparisons, in 2004, 284 3-year-olds from control cities were baseline examined for caries, then 276 children at the age 8 years in 2009. INTERVENTIONS In six intervention communities: 1,498 examined children received 0.5 mg F in 100 or 200 ml school milk or yogurt provided each school day; a further 180 received non-fluoridated milk. In two control communities, fluoride was not added to 284 children's school milk. MAIN OUTCOME MEASURES Dental caries experience of primary, and permanent teeth. RESULTS For primary teeth, caries increments were 46% (p < 0.001) and 30% (p < 0.01) lower in the fluoridated milk groups compared with non-fluoridated milk groups in the intervention and control communities, respectively. For permanent teeth those reductions were 61% and 53% (p < 0.001). The cross-sectional comparisons of 8-year-olds showed significant changes in dental caries experience over time; in children consuming fluoridated milk the level of dmfs fell by 43% (2004 and 2009) against 11% in the control group. Among children consuming fluoridated milk the DMFS fell 68% against rising 3% in the controls. CONCLUSIONS Fluoridated milk delivered daily in schools in Bulgaria resulted in substantially lower caries development compared with children in schools receiving milk without added fluoride. The nation-wide experiences from milk fluoridation indicate that such a public health scheme can be effective to the global fight against dental caries of children.
Phagocytic Activity and Monocyte Chemotactic Protein Expression by Pulmonary Macrophages in Persistent Pulmonary Cryptococcosis

ABSTRACT The mechanisms by which Cryptococcus neoformans persists in an immunocompetent host are not well understood. Using a rat model of persistent infection, we investigated the ability of pulmonary macrophages (PuM) to phagocytize C. neoformans and produce monocyte chemotactic protein 1 (MCP-1) as a function of the length of time of infection and opsonin. The ability of macrophages to affect serum-mediated phagocytosis varied over the course of infection and was dependent on CD11b/c and CD18 expression. Infection resulted in increased MCP-1 levels within the lung, though the actual amounts varied over the course of infection. Immunohistochemical studies localized MCP-1 expression to macrophages and epithelioid cells. Enhanced production of MCP-1 by PuM from infected rats was confirmed by ex vivo studies. Induction of MCP-1 following serum-mediated phagocytosis was observed for PuM from both infected and noninfected rats and depended on the interaction of C. neoformans with CD11b/c and CD18. Specific antibody was more efficient than serum in promoting phagocytosis and consistently elicited more MCP-1. The relative amount of MCP-1 produced in association with phagocytosis was similar for PuM at all lengths of time of infection. Decreased MCP-1 production was observed for PuM obtained from older rats, including long-term (8 to 10 months)-infected and age-matched controls, suggesting that aging may affect the production of MCP-1 by PuM in response to cryptococcal infection. In summary, our results show that macrophages are an important source of MCP-1 during pulmonary cryptococcosis and that MCP-1 production is actively regulated during infection. Furthermore, we find that phagocytosis of C. neoformans can serve as an important stimulus for MCP-1 production by PuM, though the efficiency of this process is dependent on the opsonin type and may be affected by aging.
The New Madrid Seismic Zone: Not Dead Yet

Statistical modeling of aftershock occurrences shows that the central United States is still active, despite low active deformation rates. The extent to which ongoing seismicity in intraplate regions represents long-lived aftershock activity is unclear. We examined historical and instrumental seismicity in the New Madrid central U.S. region to determine whether present-day seismicity is composed predominantly of aftershocks of the 1811–1812 earthquake sequence. High aftershock productivity is required both to match the observation of multiple mainshocks and to explain the modern level of activity as aftershocks; synthetic sequences consistent with these observations substantially overpredict the number of events of magnitude ≥ 6 that were observed in the past 200 years. Our results imply that ongoing background seismicity in the New Madrid region is driven by ongoing strain accrual processes and that, despite low deformation rates, seismic activity in the zone is not decaying with time. Rolling Under New Madrid During 1811–1812, the New Madrid Seismic Zone experienced a sequence of three large intraplate earthquakes and at least one comparably sized aftershock. There have been no earthquakes of similar magnitudes since then. Using a combination of historical data dating back to the original large events and an epidemic-type aftershock sequence model, Page and Hough (p. 762, published online 23 January) found that the current low seismicity is not part of an aftershock sequence. Instead, despite low observable deformation rates, there is ongoing accumulation of strain, leaving the potential for large earthquakes in the region.
Methylenetetrahydrofolate reductase gene polymorphisms: association with risk for pediatric acute lymphoblastic leukemia in north Indians

Genetic polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene have been associated with the development of acute leukemias and various malignancies. We conducted a case–control study in 95 north Indian children with acute lymphoblastic leukemia (ALL) and 255 controls, to investigate the role of MTHFR C677T and A1298C polymorphisms as risk factors in the development of ALL. PCR-RFLP on genomic DNA was carried out to determine C677T and A1298C genotypes. The frequency of MTHFR C677T for the T allele was found to be 23.2% among patients and 18.2% among controls. The frequency of the C allele in MTHFR A1298C was 44.2% among cases and 48.2% in controls. Patients showed a higher frequency of heterozygosity for the MTHFR C677T polymorphism as compared to controls (40% vs 27.8%; OR = 1.73, 95% CI 1.02–2.91, p = 0.02), and the A1298C polymorphism did not show any difference in genotype frequency between cases and controls. MTHFR 677CC/1298AC genotype frequencies showed a statistically significant difference between cases and controls (OR = 0.58, 95% CI 0.34–1.01, p = 0.04). In conclusion, our study in north Indian controls and patients with pediatric ALL showed increased frequency for MTHFR C677T in the heterozygous state and no significant difference in the frequency of A1298C genotype between the two groups.
Empirical study of the readiness of public servants on the adoption of e-government

E-government is a new and emerging area of interest in the field of e-businesses which employs ICTs to enhance the access to and delivery of government information and services to citizens, businesses, government employees, and other agencies. In this work a survey of the readiness of public servants on the adoption of e-government is carried out. This study identifies the determinants of civil servant users' adoption of e-government services in four different ministries in Ondo State Nigeria using an amended version of the UTAUT model with seven constructs. The findings revealed that performance expectancy and self efficacy are significantly associated with age, while social influence, attitude behaviour and self efficacy are strongly associated with gender. The research also provides useful insights into the motivations underlying the intentions to use e-government services in developing countries.
Project Troubleshooting: Tiger Teams for Reactive Risk Management

Large long-term projects with many stakeholders generally entail unforeseen risks and events that cannot, in principle, be predicted. Given the impracticality of pre-planning for every possible contingency, managers must react to inevitable disruptions, respond to unexpected events, update risk management plans, rescope the project, and problem-solve. Contrary to these all-too-common project occurrences, management continues to view the project as a deterministic process. The belief is that risk can be anticipated and projects executed as planned. The view presented in this paper is that pragmatic project management involves a practical balance between proactive risk management tools and reactive problem-solving tools.
EVALUATION of SHORT‐TERM and LONG‐TERM TREATMENT of the NARCOLEPSY SYNDROME WITH CLOMIPRAMINE HYDROCHLORIDE

Clinical examinations, questionnaires, and 24‐ or 36‐hour polygraphic recordings were performed on 21 adult patients with the narcolepsy syndrome to investigate the short‐ and long‐term effects of clomipramine HCL. Cataplexy was improved by the medication, but tolerance was observed after 4 1/2 months of treatment. Clomipramine HCL induced significant changes in the sleep EEG, chin EMG, and EOG. In two patients, clomipramine HCL caused a nocturnal myoclonia that produced insomnia. Sexual side effects were seen with clomipramine HCL, particularly in males. A combination of clomipramine HCL and L‐Dopa apparently prevented this difficulty in one patient. A rebound of cataplexy was seen during the 15 days following withdrawal of the drug. Methysergide maleate was found to be ineffective on cataplexy in four patients.
Blind Stereoscopic Video Quality Assessment: From Depth Perception to Overall Experience

Stereoscopic video quality assessment (SVQA) is a challenging problem. It has not been well investigated on how to measure depth perception quality independently under different distortion categories and degrees, especially exploit the depth perception to assist the overall quality assessment of 3D videos. In this paper, we propose a new depth perception quality metric (DPQM) and verify that it outperforms existing metrics on our published 3D video extension of High Efficiency Video Coding (3D-HEVC) video database. Furthermore, we validate its effectiveness by applying the crucial part of the DPQM to a novel blind stereoscopic video quality evaluator (BSVQE) for overall 3D video quality assessment. In the DPQM, we introduce the feature of auto-regressive prediction-based disparity entropy (ARDE) measurement and the feature of energy weighted video content measurement, which are inspired by the free-energy principle and the binocular vision mechanism. In the BSVQE, the binocular summation and difference operations are integrated together with the fusion natural scene statistic measurement and the ARDE measurement to reveal the key influence from texture and disparity. Experimental results on three stereoscopic video databases demonstrate that our method outperforms state-of-the-art SVQA algorithms for both symmetrically and asymmetrically distorted stereoscopic video pairs of various distortion types.
Early versus late antiepileptic drug withdrawal for people with epilepsy in remission.

BACKGROUND Antiepileptic drugs ( AEDs) are used to prevent seizures but are associated with both short and long term adverse effects. When epilepsy is in remission, it may be in the patient's best interest to discontinue medication. However, the optimal timing of AED discontinuation is not known. OBJECTIVES To quantify seizure relapse risk after early (less than two seizure free years) versus late (more than two seizure free years) AED withdrawal in adult and pediatric epilepsy patients. To assess which variables modify the risk of seizure recurrence. SEARCH STRATEGY We searched the Cochrane Epilepsy Group trials register, the Cochrane Controlled trials register (Cochrane Library Issue 4, 2000), MEDLINE (January 1996 to January 2001), EMBASE, Index Medicus, CINAHL, as well as hand-searching of journals. SELECTION CRITERIA Randomized controlled trials that evaluate withdrawal of AEDs after varying periods of seizure remission in adult and pediatric epilepsy patients with or without blinding were included. Included studies compared an early versus late AED discontinuation. DATA COLLECTION AND ANALYSIS Two reviewers independently extracted data and assessed trial quality. Relative risks with 95% confidence intervals were calculated for each trial. Summary relative risks and 95% confidence intervals for dichotomous data were calculated using a random effects model. A test of statistical heterogeneity was conducted for each pooled relative risk calculation. MAIN RESULTS Seven eligible controlled trials were included in the analysis representing 924 randomized pediatric patients. There were no eligible trials evaluating adult seizure free patients. The pooled relative risk for seizure relapse in early versus late AED withdrawal was 1.32 (95% confidence interval 1.02 to 1.70). On the basis of this estimate, the number needed to harm, that is expose an individual to a higher risk of seizure relapse because of early withdrawal of AED, is 10. Early discontinuation was associated with greater relapse rates in patients with partial seizures[pooled RR = 1.52; 95% confidence interval 0.95 to 2.41] or an abnormal EEG [pooled RR=1.67; 95% confidence interval 0.93 to 3.00]. REVIEWER'S CONCLUSIONS There is evidence to support waiting for at least two or more seizure free years before discontinuing AEDs in children, particularly if individuals have an abnormal EEG and partial seizures. There is insufficient evidence to establish when to withdraw AEDs in pediatric patients with generalized seizures. There is no evidence to guide the timing of withdrawal of AEDs in adult seizure free patients. Further blinded randomized controlled trials are needed to identify the optimal timing of AED withdrawal and risk factors predictive of relapse.
Rheb promotes cancer cell survival through p27Kip1‐dependent activation of autophagy

We previously found that the small GTPase Rheb regulates the cell‐cycle inhibitor p27KIP1 (p27) in colon cancer cells by a mTORC1‐independent mechanism. However, the biological function of the Rheb/p27 axis in cancer cells remains unknown. Here, we show that siRNA‐mediated depletion of Rheb decreases survival of human colon cancer cells under serum deprivation. As autophagy can support cell survival, we analyzed the effect of Rheb on this process by detecting the modification of the autophagy marker protein LC3 by western blot and imunofluorescence. We found that Rheb promotes autophagy in several human cancer cell lines under serum deprivation. Accordingly, blocking autophagy inhibited the pro‐survival effect of Rheb in colon cancer cells. We then analyzed whether p27 was involved in the biological effect of Rheb. Depletion of p27 inhibited colon cancer cell survival, and Rheb induction of autophagy. These results suggest that p27 has an essential role in the effect of Rheb in response to serum deprivation. In addition, we demonstrated that the role of p27 in autophagy stands on the N‐terminal portion of the protein, where the CDK‐inhibitory domain is located. Our results indicate that a Rheb/p27 axis accounts for the activation of autophagy that supports cancer cell survival. Our work therefore highlights a biological function of Rheb and prompts the need for future studies to address whether the mTORC1‐independent Rheb/p27 axis could contribute to tumorigenesis and/or resistance to mTOR inhibitors. © 2015 Wiley Periodicals, Inc.
The impact of personality on acceptance of privacy-sensitive technologies: A comparative study of RFID and finger vein authentication systems

The wide and rapid diffusion of ICT has created an environment where consumers must interact with new technology with which they may not be comfortably familiar. Although they often do not fully understand the technological details of these products, consumers find that they need to use a variety of services based on newly introduced ICT, such as Radio Frequency Identification Technology(RFID), Near Field Communication (NFC), or contactless Finger Vein Authentication System (FVAS). Questions regarding whether or not consumers are comfortable with a new technology and how they react when the new technology is introduced need to be addressed, especially in the case where privacy sensitive technology is concerned. This paper investigates the differences in two systems and the reaction to these differences by comparing the results of a questionnaire administered to two separate groups of subjects. It also presents findings from applying the Big-Five Test for Personal Traits to these same groups in an analysis that examines the correlation between Neuroticism and attitudes toward new ICT.
Economic evaluation of toric intraocular lens: a short- and long-term decision analytic model.

OBJECTIVE To assess the economic value of improved uncorrected visual acuity among patients with cataract and preexisting astigmatism treated with toric intraocular lenses (IOLs) compared with conventional monofocal IOLs. METHODS We developed a decision analytic model of hypothetical patients with preexisting astigmatism. We examined costs and outcomes among patients 65 years and older with cataract and preexisting astigmatism (1.5-3.0 diopters) who were receiving either toric or conventional IOLs with and without intraoperative refractive correction (IRC). Data were obtained from the literature and from a survey of 60 US ophthalmologists. Total medical costs of bilateral treatment were calculated for the first posttreatment year and remaining lifetime. Cost-effectiveness and cost-utility outcomes were computed. Future costs and utilities were discounted by 3%. RESULTS A larger proportion of patients receiving toric IOLs achieved distance vision spectacle independence (67%) and uncorrected visual acuity of 20/25 or better OU (53%) compared with conventional IOLs with (63% and 48%, respectively) or without IRC (53% and 44%, respectively), resulting in fewer future vision corrections. Toric IOLs provided an additional 10.20 quality-adjusted life years (QALYs) compared with conventional IOLs with (10.14 QALYs) and without IRC (10.10 QALYs). Higher first-year costs of the toric IOL ($5739) compared with the conventional IOL with ($5635) or without ($4687) IRC were offset by lifetime cost savings of $34 per patient, $393 per patient achieving uncorrected visual acuity of 20/25 or better, and $349 per QALY compared with the conventional IOL without IRC. CONCLUSIONS Toric IOLs reduce lifetime economic costs by reducing the need for glasses or contact lenses following cataract removal. These results can inform physicians and patients regarding the value of toric IOLs in the treatment of cataract and preexisting astigmatism.
Biliary complications after liver transplantation: A review

After liver transplantation, the prevalence of complications related to the biliary system is 6–35%. In recent years, the diagnosis and treatment of biliary problems has changed markedly. The two standard methods of biliary reconstruction in liver transplant recipients are the duct-to-duct choledochocholedochostomy and the Roux-en-Y-hepaticojejunostomy. Biliary leakage occurs in approximately 5–7% of transplant cases. Leakage from the site of anastomosis, the T-tube exit site and donor or recipient remnant cystic duct is well described. Symptomatic bile leakage should be treated by stenting of the duct by endoscopic retrograde cholangiopancreatography (ERCP) or percutaneous transhepatic cholangiography (PTCD). Biliary strictures can occur at the site of the anastomosis (anastomotic stricture; AS) or at other locations in the biliary tree (non-anastomotic strictures; NAS). AS occur in 5–10% of cases and are due to fibrotic healing. Treatment by ERCP or PTCD with dilatation and progressive stenting is successful in the majority of cases. NAS can occur in the context of a hepatic artery thrombosis, or with an open hepatic artery (ischaemic type biliary lesions or ITBL). The incidence is 5–10%. NAS has been associated with various types of injury, e.g. macrovascular, microvascular, immunological and cytotoxic injury by bile salts. Treatment can be attempted with multiple sessions of dilatation and stenting of stenotic areas by ERCP or PTCD. In cases of localized diseased and good graft function, biliary reconstructive surgery is useful. However, a significant number of patients will need a re-transplant. When biliary strictures or ischaemia of the graft are present, stones, casts and sludge can develop.
Transmembrane-deletion Mutants of the Membrane-type Matrix Metalloproteinase-1 Process Progelatinase A and Express Intrinsic Matrix-degrading Activity (*)

Membrane-type matrix metalloproteinase-1 (MT-MMP-1) has been proposed to play a critical role in regulating the expression of tissue-invasive phenotypes in normal and neoplastic cells by directly or indirectly mediating the activation of progelatinase A. To begin characterizing MT-MMP-1 structure-function relationships, transmembrane-deletion mutants were constructed, and the processing of the zymogens as well as the enzymic activity of the mature proteinases was analyzed. We now demonstrate that pro-MT-MMP-1 mutants are efficiently processed to active proteinases following post-translational endoproteolysis immediately downstream of an Arg-Arg-Lys-Arg basic motif by a proprotein convertase-dependent pathway. The secreted form of active MT-MMP-1 not only displays an N terminus identical with that described for the processed wild-type enzyme at Tyr (Strongin, A. Y., Collier, I., Bannikov, G., Marmer, B. L., Grants, G. A., and Goldberg, G. I.(1995) J. Biol. Chem. 270, 5331-5338), but also directly mediated progelatinase A activation via a two-step proteolytic cascade indistinguishable from that observed with intact cells. Furthermore, although the only function previously ascribed to MT-MMP-1 is its ability to act as a progelatinase A activator, purified transmembrane deletion mutants also expressed proteolytic activities against a wide range of extracellular matrix molecules. Given recent reports that MT-MMP-1 ectodomains may undergo intercellular transfer in vivo (Okada, A., Bellocq, J.-P., Rouyer, N., Chenard, M.-P., Rio, M.-C., Chambon, P., and Basset, P.(1995) Proc. Natl. Acad. Sci. U. S. A. 92, 2730-2734), our data suggest that soluble forms of the proteinase confer recipient cells with the ability to not only process progelatinase A, but also directly degrade extracellular matrix components.