Miracle-dz/UniFAR-FTUs huggingface dataset:
Severe fetal growth restriction at 26–32 weeks: key messages from the TRUFFLE study

C. M. BILARDO1 , K. HECHER2, G. H. A. VISSER3, A. T. PAPAGEORGHIOU4, N. MARLOW5, B. THILAGANATHAN4, A. VAN WASSENAER-LEEMHUIS6, T. TODROS7, K. MARSAL8, T. FRUSCA9, B. ARABIN10, C. BREZINKA11, J. B. DERKS12, A. DIEMERT2, J. J. DUVEKOT13, E. FERRAZZI14, W. GANZEVOORT15, P. MARTINELLI16, E. OSTERMAYER17, D. SCHLEMBACH18, H. VALENSISE19, J. THORNTON20, H. WOLF15 and C. LEES21* , on behalf of the TRUFFLE Group# 1Fetal Medicine Unit, Department of Obstetrics and Gynecology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands; 2Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; 3University Medical Center, Division of Woman and Baby, Utrecht, The Netherlands; 4St George’s, University of London and St George’s University Hospitals NHS Foundation Trust, Molecular and Clinical Sciences Research Institute, London, UK; 5Department of Academic Neonatology, UCL Institute for Women’s Health, London, UK; 6Department of Neonatology, Emma Children’s Hospital Academic Medical Centre, Amsterdam, The Netherlands; 7Department of Obstetrics & Gynecology, University of Turin, Turin, Italy; 8Department of Obstetrics and Gynecology, Lund University, University Hospital, Lund, Sweden; 9Maternal-Fetal Medicine Unit, University of Parma, Parma, Italy; 10Department of Perinatology, Isala Clinics, Zwolle, The Netherlands, and Center for Mother and Child of the Philipps University, Marburg, Germany; 11Department of Obstetrics and Gynecology, Medical University Innsbruck, Innsbruck, Austria; 12Perinatal Center, Wilhelmina Children’s Hospital, Utrecht, The Netherlands; 13Division of Obstetrics and Prenatal Medicine, Department of Obstetrics and Gynaecology, Erasmus MC, Rotterdam, The Netherlands; 14Buzzi Children’s Hospital, University of Milan, Milan, Italy; 15Department of Obstetrics and Gynecology, Academic Medical Centre, Amsterdam, The Netherlands; 16Department of Gynecology and Obstetrics, University Federico II of Naples, Naples, Italy; 17Section of Perinatal Medicine, Department of Obstetrics and Gynecology, Technical University, Munich, Germany; 18Department of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria; 19Department of Biomedicine, Tor Vergata University, Policlinico Casilino, Rome, Italy; 20Department of Obstetrics and Gynaecology, City Hospital, Nottingham, UK; 21Department of Surgery and Cancer, Imperial College London, London, UK, and Department of Development and Regeneration, KU Leuven, Leuven, Belgium ∗Correspondence. (e-mail: christoph.lees@nhs.net)
New concept of ileocecal junction: intussusception of the terminal ileum into the cecum.

AIM To prove that the terminal ileum is intussuscepted into the cecum creating the ileocecal junction, contrary to previous valvular concept which has been widely believed. METHODS This study is based on gross and microscopic examinations of fresh specimens derived from colonic operations (right hemicolectomy or subtotal colectomy). Data compiled from observing and dissecting of specimens of seven patients are used to examine both gross and microscopic appearance of ileocecal junction. RESULTS Intussusception of the terminal ileum was found in every specimen. However, the length of intussusception was different in each specimen. CONCLUSION Gross and microscopic appearance studies suggest that the terminal ileum is intussuscepted into the cecum.
Carcinoembryonic antigen levels in advanced gastric carcinoma

Serial CEA levels were measured in 157 patients with advanced inoperable gastric carcinoma entered in a controlled trial of cytotoxic therapy. In 49 (31%) of cases initial levels were greater than 50 ng/ml. However, serial measurements were only possible in 57 (36%) cases and results were prognostically valuable in only 15 (9.5%) of cases.
The Role of Institutions and Immigrant Networks in Firmsâ€™ Offshoring Decisions

The offshoring of production by multinational firms has expanded dramatically in recent decades, increasing these firms' potential for economic growth and technological transfers across countries. What determines the location of offshore production? How do countries' policies and characteristics affect the firm's decision about where to offshore? Do firms choose specific countries because of their policies or because they know them better? In this paper, we use a very rich dataset on Danish firms to analyze how decisions to offshore production depend on the institutional characteristics of the country and firm-specific bilateral connections. We find that institutions that enhance investor protection and reduce corruption increase the probability that firms offshore there, while those that increase regulation in the labor market decrease such probability. We also show that a firm's probability of offshoring increases with the share of its employees who are immigrants from that country of origin.
LONG–TERM AUTONOMY OF MOBILE ROBOTS IN CHANGING ENVIRONMENTS

This habilitation thesis presents research that aims to enable long-term deployment of mobile robots in changing environments. The presented approaches encompass methods that ensure robustness of autonomous visual navigation in outdoor environments for prolonged time periods, spatio-temporal representations that explicitly model the environment changes over time, and supporting software modules that enable robust and accurate robot localisation. The main contribution of the thesis is a novel approach that allows to incorporate the notion of time into most stationary environment models used in mobile robotics. This is achieved by representing the uncertainty of the environment states not by fixed probabilities, but by probabilistic functions of time, represented in the frequency domain. The method allows to integrate unlimited numbers of sparse and irregular observations obtained during long-term deployments of mobile robots into memory-efficient models that reflect the persistence and recurrence of environment variations. The frequency-enhanced spatio-temporal models allow to predict the future environment states, which improves the efficiency of mobile robot operation in changing environments. In this thesis, we present a series of articles, which demonstrate that the proposed approach improves mobile robot localization, path and task planning, activity recognition, human-robot interaction and allows for life-long spatio-temporal exploration of perpetually-changing environments. Tato habilitačnı́ práce se zabývá problémem dlouhodobé samostatnosti mobilnı́ch robotů v prostředı́ch, které podléhajı́ postupným změnám. Práce prezentuje metody, které zvyšujı́ spolehlivost dlouhodobé vizuálnı́ navigace mobilnı́ch robotů v exteriérech, prostoročasové representace světa, které explicitně modelujı́ změny prostředı́ v čase, a nástroje, které umožňujı́cı́ spolehlivou a přesnou lokalizaci mobilnı́ch robotů. Hlavnı́m přı́nosem práce je princip, který umožňuje rozšı́řit většinu prostorových representacı́ světa použı́vaných v robotice tak, aby tyto zahrnovaly pojem času. Tohoto rozšı́řenı́ je dosaženo tı́m, že neurčitost stavů prostředı́ nenı́ modelována jako statická pravděpodobnost, ale jako pravděpodobnostnı́ funkce času, která je representována ve frekvenčnı́ doméně. Výše uvedený princip umožňuje integrovat neomezená množstvı́ dlouhodobých nepravidelných pozorovánı́ stavů daného prostředı́ robotem do paměťově nenáročných modelů, které efektivně reprezentujı́ základnı́ časové charakteristiky pozorovaných změn. Tyto representace umožňujı́ mobilnı́mu robotu předpovı́dat budoucı́ stavy prostředı́, což v dlouhodobém časovém horizontu zvyšuje jeho efektivitu. V této práci ukážeme, že použitı́m výše uvedené metody se při dlouhodobých nasazenı́ch mobilnı́ch robotů zlepšuje efektivita jejich lokalizace, plánovánı́, rozvrhovánı́, rozpoznávánı́ a interakce s lidmi. Dále ukážeme, že kombinace této metody s teoriı́ informace vede vede mobilnı́ roboty k inteligentnı́mu průzkumu měnı́cı́ch se prostředı́.
Association between child and adolescent obesity and parental weight status: A cross-sectional study from rural north China

Objective To investigate the relationship between child and adolescent obesity, and parental weight status. Methods Height and weight were measured in Chinese children and adolescents aged 6–17 years old. Information was collected concerning parental weight and height, and possible covariates, using a questionnaire. The body mass index (BMI) of each study participant and their parents was calculated. On the basis of the BMI, parents were categorized as normal, overweight or obese, and children and adolescents were categorized as normal or obese. Results Of the 5 041 participants included in the study, 6.82% were obese. Child or adolescent obesity was significantly associated with parental obesity. When both parents were obese, there was a 3.62-fold increased risk of obesity compared with those whose parents were of normal weight. Obesity in fathers was associated with a heightened risk of obesity in female children, whereas obesity in mothers was associated with a heightened risk of obesity in male children. Conclusions Parental obesity was a predictor of obesity in children and adolescents. It is therefore of key importance to prevent obesity in children who have one or more obese parents.
Leadership Styles, Turnover Intentions and the Mediating Role of Organizational Commitment

The aim of this research article is to investigate the association between leadership styles, organizational commitment and turnover intentions. In particular, this study focuses on the mediation effect of organizational commitment on the association between styles of leadership and turnover intentions. One hundred and seventy (170) questionnaires were distributed and one hundred and twenty one (121) questionnaires were returned, indicating a response rate of 71.2%. A non-probability convenience sampling technique was used to collect data. The population of this study consists of the insurance sector of Pakistan. Employees working at different hierarchal level were targeted, comprising non-managerial and managerial levels including upper, middle, and lower level management. The data were analyzed by using statistical package of SPSS 20th version. It was found that there is negative insignificant association between turnover intentions and transactional and transformational leadership styles. Also, organizational commitment mediated the association between styles of leadership and turnover intentions. Managers should be aware of the advantages and disadvantages of different leadership styles as these may affect organizational commitment of subordinates and eventually, positive or negative effect on turnover intentions. Keywords: Styles of Leadership, Employee Turnover Intentions, Organizational Commitment, Insurance Companies, Pakistan.
Integration of lncRNA–miRNA–mRNA reveals novel insights into oviposition regulation in honey bees

Background The honey bee (Apis mellifera) is a highly diverse species commonly used for honey production and pollination services. The oviposition of the honey bee queen affects the development and overall performance of the colony. To investigate the ovary activation and oviposition processes on a molecular level, a genome-wide analysis of lncRNAs, miRNAs and mRNA expression in the ovaries of the queens was performed to screen for differentially expressed coding and noncoding RNAs. Further analysis identified relevant candidate genes or RNAs. Results The analysis of the RNA profiles in different oviposition phase of the queens revealed that 740 lncRNAs, 81 miRNAs and 5,481 mRNAs were differently expressed during the ovary activation; 88 lncRNAs, 13 miRNAs and 338 mRNAs were differently expressed during the oviposition inhibition process; and finally, 100 lncRNAs, four miRNAs and 497 mRNAs were differently expressed during the oviposition recovery process. In addition, functional annotation of differentially expressed RNAs revealed several pathways that are closely related to oviposition, including hippo, MAPK, notch, Wnt, mTOR, TGF-beta and FoxO signaling pathways. Furthermore, in the QTL region for ovary size, 73 differentially expressed genes and 14 differentially expressed lncRNAs were located, which are considered as candidate genes affecting ovary size and oviposition. Moreover, a core set of genes served as bridges among different miRNAs were identified through the integrated analysis of lncRNA-miRNA-mRNA network. Conclusion The observed dramatic expression changes of coding and noncoding RNAs suggest that they may play a critical role in honey bee queens’ oviposition. The identified candidate genes for oviposition activation and regulation could serve as a resource for further studies of genetic markers of oviposition in honey bees.
HRAS and the Costello syndrome

Costello syndrome (CS) is a complex developmental disorder involving characteristic craniofacial features, failure to thrive, developmental delay, cardiac and skeletal anomalies and a predisposition to develop neoplasia, both benign and malignant. CS is caused by activating germline mutations in HRAS and belongs to an exciting class of genetic syndromes that are caused by perturbation of function through the Ras pathway. Some of these other syndromes include Noonan syndrome, LEOPARD syndrome, neurofibromatosis 1 and cardio‐facio‐cutaneous syndrome. Ras is a critical signaling hub in the cell and is activated by receptor tyrosine kinases, G‐protein‐coupled receptors, cytokine receptors and extracellular matrix receptors. The downstream effectors of Ras are many and control vital cellular functions including cell cycle progression, cell survival, motility, transcription, translation and membrane trafficking. Understanding the genetic etiology of CS is the first step in gaining insight to the role Ras plays in human development, cellular signaling and cancer pathogenesis.
Diversification of motor skills rely upon an optimal amount of variability of perceptive and motor task demands

In this study, motor skill was proposed as being organized into two hierarchical levels: macro- and microstructures, which would be responsible for the consistency and variability of actions, respectively. Constant practice was considered responsible for promoting the skill’s macrostructure formation and, following random practice, its diversification (microstructure). The aim of this study was to investigate the effects of the number of items varied during random practice in order to promote diversification of the skill on the adaptive process of motor learning. A coincident timing complex task was manipulated in terms of perceptive (experiment 1), motor (experiment 2) and perceptive coupled with motor (experiment 3) requirements. In each experiment, 22 children were divided into two groups according to the amount of variability (three or six). Also, the design included two phases: stabilization and adaptation. Results showed that when the motor skill was diversified in relation to perceptive and motor demands separately (experiments 1 and 2), there were no differences between groups with variability of three and six parameters during the adaptation. No learning occurred for both groups in experiment 3. In conclusion, a minimum amount of variability in perceptive and motor task demands varying separately during practice (three variations) was enough to provide the needed flexibility for adaptation in the motor skill.
Adaptive density estimation in deconvolution problems with unknown error distribution

A density deconvolution problem with unknown distribution of the errors is considered. To make the target density identifiable, one has to assume that some additional information on the noise is available. We consider two different models: the framework where some additional sample of the pure noise is available, as well as the repeated observation model, where the contaminated random variable of interest can be observed repeatedly. We introduce kernel estimators and present upper risk bounds. The focus of this work lies on the optimal data driven choice of the smoothing parameter using a penalization strategy
Are parents doing what they want to do? Congruency between parents’ actual and desired participation in the care of their hospitalized child

Family-centered care is integral to pediatric nursing practice, and includes supporting parents to participate in their hospitalized child’s care. Research to date suggests that parents’ actual participation in care may differ from their desired participation in care, and that such discrepancies may cause parental distress. Supporting parental participation in a way that facilitates congruency between actual and desired participation may contribute to a satisfying experience for families of hospitalized children. This cross-sectional study measured parents’ actual and desired level of participation in care of their hospitalized child and examined the congruency between them. Participants (N = 191), the majority of whom were mothers, provided demographic data and completed two instruments measuring desired and actual participation in care. Study results indicate a significant difference between parents’ actual and desired participation (t = −9.382, df = 190, p < 0.0001). The majority of parents expressed a desire to increase their participation. The care activities in which these parents participated are described, including providing comfort, assisting with activities of daily living and advocating for their child. Nurses caring for hospitalized children and their families need to remember that parental preferences for participation will vary, and they need to be prepared to support parents’ participation at the level parents choose. Understanding congruency between actual and desired levels of participation can promote awareness of parents’ preferences for participation.
Impact of the Pneumococcal Conjugate Vaccine and Antibiotic Use on Nasopharyngeal Colonization by Antibiotic Nonsusceptible Streptococcus pneumoniae, Alaska, 2000[FIGURE DASH]2010

Background: We describe the relative impact of the heptavalent pneumococcal conjugate vaccine (PCV7, introduced 2001) and antibiotic use on colonization by antibiotic-resistant pneumococci in urban Alaskan children during 2000–2010. Methods: We obtained nasopharyngeal swab specimens from a convenience sample of children aged <5 years at clinics annually during 2000–2004 and 2008–2010. PCV7 status and antibiotic use <90 days before enrollment were determined by interview/medical records review. Pneumococci were characterized by serotype and susceptibility to penicillin (PCN). Isolates with full PCN resistance (PCN-R) or intermediate PCN resistance (PCN-I) were classified as PCN-NS. Results: We recruited 3496 children (median, 452 per year). During 2000–2010, a range of 18–29% per year of children used PCN/amoxicillin (P value for trend = 0.09); the proportion age-appropriately vaccinated with PCV7 increased (0[FIGURE DASH]90%; P < 0.01). Among pneumococcal isolates, the PCV7-serotype proportion decreased (53–<1%; P < 0.01) and non[FIGURE DASH]PCV7-serotype proportion increased (43–95%; P < 0.01). PCN-R pneumococcal colonization prevalence decreased (23–9%; P < 0.01) and PCN-I pneumococcal colonization prevalence increased (13–24%; P < 0.01); overall PCN-NS pneumococcal colonization prevalence was unchanged. PCN-NS among colonizing PCV7-type and non[FIGURE DASH]PCV7-type pneumococci remained unchanged; a mean of 31% per year of PCV7-type and 10% per year of non[FIGURE DASH]PCV7-type isolates were PCN-R, and 10% per year of PCV7 and 20% per year of non[FIGURE DASH]PCV7-type isolates were PCN-I. Conclusions: Overall, PCN-NS pneumococcal colonization remained unchanged during 2000–2010 because increased colonization by predominantly PCN-I non-PCV7 serotypes offset decreased colonization by predominantly PCN-R PCV7 serotypes. Proportion PCN-NS did not increase within colonizing pneumococcal serotype groups (PCV7 vs. non-PCV7) despite stable PCN use in our population.
Density of platelet collagen receptors glycoprotein VI and alpha2beta1 and prior myocardial infarction in human subjects, a pilot study.

BACKGROUND Prior studies evaluating whether platelet collagen receptors affect risk of myocardial infarction (MI) have used common polymorphisms thought to affect receptor density, and have yielded conflicting results. Our objective in the current pilot study was to obtain preliminary information on the relationship between platelet collagen receptor density and prior MI. MATERIAL/METHODS We measured glycoprotein VI (GPVI) and integrin alpha2beta1 density by flow cytometry using FITC-conjugated monoclonal antibodies in consecutive subjects from an outpatient cardiology practice. We used a case-control design to match 77 patients with prior MI to 77 control patients. Matching was performed on the basis of traditional risk factors for MI. RESULTS The mean GPVI density was 14% higher in those with prior MI (P = 0.098), and the alpha2beta1 density was 6% higher in those with prior MI (P = 0.49). A GPVI or alpha2beta1 density within the lowest decile was associated with a lower MI prevalence (OR = 6.3, 95% CI: 1.3-29.2 P = 0.009). CONCLUSIONS Our preliminary data suggests that platelet collagen receptor density, when measured directly, may be related to prior myocardial infarction. An appropriately sized clinical study using this methodology is warranted to further investigate whether collagen receptor density serves as a novel risk factor for myocardial infarction.
Fraud Detection: Using Of Data Mining In Accounting Information System

Fraud detection is the identification of fraudulent behavior once it has occurred. Once detection has occurred action can be taken to limit the fraudulent activity. Fraud detection methods are in a constant state of change or flux due to the nature of fraud. The process of data mining is one of methods for obtain the required data for analysis, study, take preventive measures, administrative decisions and fraud detection. This study aims at detecting fraud in evading the payment of the cheques and promissory notes payable by the customer in the Palestinian work environment and enforcing them on one of the largest Palestinian companies that use the system of sale by installments through promissory notes and cheques very large through the extraction of data from the accounting information system. A qualitative research methodology is adopted in undertaking the investigation to understand the actual conduct of practices that aims to recommend improvements for fraud control and detection it and prevent it through data mining and analyze them and making decision for solution these problems. The results indicate that the company has a lot of cheques and promissory notes that are not paid very much therefore the company suffers from this scourge very much by many fraudulent customers, which affects its activities and profits. The data was mining from the accounting information system "Priority" which is using in this company. The research methodology was used these data according to the Microsoft Excel and analysis and extract the results related to the detection of this problem and prove the existence of this problem. Based on the research that aims at how to detect fraud through the data mining by the accounting information systems and the results connected to the researcher has already been detected fraud in the company to which the research was applied. As a result, the study provides information on the causes of this problem and solutions and suggestions that help to reduce them very significantly and therefore the researcher sees the need to participate between all competent authorities concerned with these matters to eliminate this scourge that threatens companies in particular and the State and society in general.