Miracle-dz/UniFAR-FTUs huggingface dataset:
The Impact of Executive Functions and Emotional Intelligence on Iowa Gambling Task Performance: Focus on Right Frontal Lobe Damage

Objective Decision-making in the Iowa Gambling Task (IGT) has been intensively studied regarding both the "hot" and "cold" components. The ventromedial prefrontal cortex is a key region involved in processing somatic marker information, though recent findings suggest dorsolateral regions are also important. The dorsolateral prefrontal cortex is also known as a substrate of executive functions-the cold component of decision-making. However, there is contradictory evidence about the role of executive functions, as well as the hot component of decision-making-emotional intelligence. Previous findings suggest that patients with right frontal lobe lesions find decision-making more problematic in IGT. The goal of this study is to replicate previous findings on IGT performance in patients with dorsolateral lesions compared to controls. Methods We obtained data from patients with right frontal lobe tumors (n = 12), localized in the dorsolateral prefrontal cortex, and healthy controls (n = 21) who undertook the IGT, Wisconsin Card Sorting Test (WCST), Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT), and D-KEFS Color-Word Interference Test. Results The performance in the IGT, WCST, and EI tests is impaired in the clinical group. At the subgroup level, we found patients had lower EI scores regarding the ability to use "emotions for thinking facilitation". However, we found an interaction between the EI scores regarding the ability "the perception and identification of emotions" and the performance on WCST only in the patient group. Conclusion This study raises the possibility of identifying components of EI which could be helpful in understanding the impairment of patients with right dorsolateral lesions.
Dietary patterns are not associated with overweight and obesity in a sample of 8900 Chinese preschool children from four cities

Globally, the prevalence of childhood obesity has substantially increased at an alarming rate. This study investigated associations between dietary patterns and overweight/obesity in 3- to 6-year-old children. Recruited children were from four prefecture-level cities in Eastern China. Childhood overweight and obesity were defined according to WHO Child Growth Standards. Individual dietary patterns were assessed by a comprehensive self-administered FFQ using thirty-five food items. Using factor analysis two dietary patterns were derived: the traditional Chinese pattern was characterised by high consumption of cereals, vegetables and fresh juices while the modern pattern was characterised by high consumption of Western fast food, Chinese fast food, sweets/sugary foods and carbonated beverages. The associations of dietary patterns with overweight/obesity were evaluated by logistic regression models. Data of 8900 preschool children from thirty-five kindergartens recruited from March to June 2015 were used in the final analysis. Adherence to the modern dietary pattern was positively associated with children's age while adherence to the traditional dietary pattern was positively associated with maternal education; these associations were statistically significant. After adjustment, we found that being in the highest tertile of any identified dietary patterns was not significantly associated with overweight and obesity. Dietary patterns are not associated with overweight/obesity in Chinese preschool children. Prospective studies are needed to establish a causal link between dietary patterns and childhood obesity.
Monetary Equilibrium and the Cost of Banking Activity

We investigate the effects of banks’ operating costs on allocations and welfare in a low interest rate environment. We introduce an explicit production function for banks in a microfounded model where banks employ labor resources, hired on a competitive market, to run their operations. In equilibrium, this generates a spread between interest rates on loans and deposits, which naturally reflects the underlying monetary policy and the efficiency of financial intermediation. In a deflation or low inflation environment, equilibrium deposits yield zero returns. Hence, banks end up soaking up labor resources to offer deposits that do not outperform idle balances, thus reducing aggregate efficiency.
Follow-up study of 6.5 years of admissions to a UK female medium secure forensic psychiatry unit

Aims and method We aimed to examine clinical and risk outcomes at follow-up, and reoffending and readmission rates, for a sample of 50 admissions to a female medium secure unit (MSU). Demographic, clinical risk assessment (HCR-20 and HoNOS-Secure) and quality of life data were collected using validated measures for all admissions to a female MSU ward in London, UK, between April 2008 and November 2014. Results All clinical and risk assessment scale scores had improved at follow-up. Quality of life compared favourably to community samples and was good for physical, social and environmental factors and acceptable for psychological health. Twenty-six per cent had at least one readmission, while 17.5% reoffended in the period studied. A longer duration of admission and use of restrictions on discharge was associated with reduced reoffending, but not readmission. Clinical implications Admission is associated with improvement on clinical risk assessment at follow-up. Longer hospital admissions and use of restrictions on discharge may be necessary to prevent reoffending in this group. Declaration of interest None.
DNA methylation of OXTR is associated with parasympathetic nervous system activity and amygdala morphology

Abstract Oxytocin has anxiolytic properties whose mechanisms of action are still being identified. DNA methylation in the promoter region of the oxytocin receptor gene (OXTR), an epigenetic modification that putatively reflects a downtuning of the oxytocin system, has previously been implicated in the regulation of fear‐related responses through the amygdala. In this study, we attempted to characterize the relationship between methylation of OXTR and anxiogenesis using two distinct endophenotypes: autonomic nervous system activity and subcortical brain structure. In 79 participants, we found that increased OXTR methylation is associated with attenuated resting parasympathetic tone, measured using high‐frequency heart rate variability. Further, we found that this relationship is mediated by brain morphology, such that OXTR methylation is associated with increased gray matter of the central amygdala which is, in turn, associated with decreased parasympathetic tone. These results further our understanding of epigenetic regulation of the human oxytocin system and its role in anxiogenesis.
Determination of citric acid pretreatment effect on nutrient content, bioactive components, and total antioxidant capacity of dried sweet potato flour

Abstract Orange flashed sweet potatoes are rich and inexpensive source of diet and antioxidants. The purpose of this study was to evaluate the effects of CA pretreatments and convective hot air drying temperature on proximate composition, bioactive components, and total antioxidant capacity of flour of five orange flashed sweet potato varieties. Moisture, protein, ether extract, ash, carbohydrate, fiber, β‐carotene, total phenolic compounds, and total antioxidant capacity in the dried flour samples were evaluated and reported in the range of 4.1–7.4%, 2.4–4.2%, 1.2–1.1.8%, 2.2–3.2%, 82.7–87.1%, 1.3–1.8%, 35.5–91.6 mg/100 g, 49.8–107.9 mg GAE/100 g, and 27.3–85.4%, respectively. The interaction effects of varieties, drying temperature, and CA concentration were significant (p ˂ 0.05) except for fiber. Kulto and SPK006/6/6 performed better for most of the parameters studied followed by SPK00/06. For almost all varieties, samples dried at 55°C and after treated in 3% CA solution had the highest percentage in terms of proximate composition, bioactive components, and total antioxidant capacities.
Inequity aversion improves cooperation in intertemporal social dilemmas

Groups of humans are often able to find ways to cooperate with one another in complex, temporally extended social dilemmas. Models based on behavioral economics are only able to explain this phenomenon for unrealistic stateless matrix games. Recently, multi-agent reinforcement learning has been applied to generalize social dilemma problems to temporally and spatially extended Markov games. However, this has not yet generated an agent that learns to cooperate in social dilemmas as humans do. A key insight is that many, but not all, human individuals have inequity averse social preferences. This promotes a particular resolution of the matrix game social dilemma wherein inequity-averse individuals are personally pro-social and punish defectors. Here we extend this idea to Markov games and show that it promotes cooperation in several types of sequential social dilemma, via a profitable interaction with policy learnability. In particular, we find that inequity aversion improves temporal credit assignment for the important class of intertemporal social dilemmas. These results help explain how large-scale cooperation may emerge and persist.
Cooperation Diversity and Innovation Performance: the Role of Firms’ Research- and Development-Orientation

This study examines how diversity in R&D collaboration partners affects the innovation performance, as measured by each firm’s sales share of innovative products taking into account the research versus development orientation of firms. To address this question, a large-scale sample of firm-level data from six waves (1999, 2002, 2005, 2008, 2011 and 2013) of the Swiss innovation survey is examined using a heteroscedastic-robust Tobit regression method. Results suggest that diversity positively affects the innovation performance of both firm types, but that the effects are strongest for researchoriented firms. In line with theoretical reasoning, a clear inverted U-shaped relationship between partner diversity and innovation performance is detected only for development-oriented firms and differences in effects are most pronounced for new-to-the-market innovations. In light of our findings, the study stresses the importance of partner diversity for research-oriented firms and (vertical) partner selectivity for development-oriented firms.
Brain and soccer: Functional patterns of brain activity during the generation of creative moves in real soccer decision‐making situations

This fMRI study investigated brain activity while soccer players were imagining creative moves in real soccer decision‐making situations. After presenting brief video clips of a soccer scene, participants had to imagine themselves as the acting player and think either of a creative or obvious move that might lead to a goal. Findings revealed stronger activation during trials in which the generation of obvious moves was required, relative to trials requiring creative moves. The reversed contrast (creative > obvious) showed no significant effects. Activations were mainly left‐lateralized, primarily involving the cuneus, middle temporal gyrus, and the rolandic operculum, which are known to support the processing of multimodal input from different sensory, motor and perceptual sources. Interestingly, more creative solutions in the soccer task were associated with smaller contrast values for the activation difference between obvious and creative trials, or even with more activation in the latter. Furthermore, higher trait creative potential (as assessed by a figural creativity test) was associated with stronger activation differences between both conditions. These findings suggest that with increasing soccer‐specific creative task performance, the processing of the manifold information provided by the soccer scenario becomes increasingly important, while in individuals with higher trait creative potential these processes were recruited to a minor degree. This study showed that soccer‐specific creativity tasks modulate activation levels in a network of regions supporting various cognitive functions such as semantic information processing, visual and motor imagery, and the processing and integration of sensorimotor and somatosensory information.
A Generalized Index for Static Voltage Stability of Unbalanced Polyphase Power Systems Including Thévenin Equivalents and Polynomial Models

This paper proposes a voltage stability index (VSI) suitable for unbalanced polyphase power systems. To this end, the grid is represented by a polyphase multiport network model (i.e., compound hybrid parameters), and the aggregate behavior of the devices in each node by Thévenin equivalents (TEs) and polynomial models (PMs), respectively. The proposed VSI is a generalization of the known $L$-index, which is achieved through the use of compound electrical parameters, and the incorporation of TEs and PMs into its formal definition. Notably, the proposed VSI can handle unbalanced polyphase power systems, explicitly accounts for voltage-dependent behavior (represented by PMs), and is computationally inexpensive. These features are valuable for the operation of both transmission and distribution systems. Specifically, the ability to handle the unbalanced polyphase case is of particular value for distribution systems. In this context, it is proven that the compound hybrid parameters required for the calculation of the VSI do exist under practical conditions (i.e., for lossy grids). The proposed VSI is validated against state-of-the-art methods for voltage stability assessment using a benchmark system, which is based on the IEEE 34-node feeder.
Hypervariable Region 1 in Envelope Protein 2 of Hepatitis C Virus: A Linchpin in Neutralizing Antibody Evasion and Viral Entry

Chronic hepatitis C virus (HCV) infection is the cause of about 400,000 annual liver disease-related deaths. The global spread of this important human pathogen can potentially be prevented through the development of a vaccine, but this challenge has proven difficult, and much remains unknown about the multitude of mechanisms by which this heterogeneous RNA virus evades inactivation by neutralizing antibodies (NAbs). The N-terminal motif of envelope protein 2 (E2), termed hypervariable region 1 (HVR1), changes rapidly in immunoglobulin-competent patients due to antibody-driven antigenic drift. HVR1 contains NAb epitopes and is directly involved in protecting diverse antibody-specific epitopes on E1, E2, and E1/E2 through incompletely understood mechanisms. The ability of HVR1 to protect HCV from NAbs appears linked with modulation of HCV entry co-receptor interactions. Thus, removal of HVR1 increases interaction with CD81, while altering interaction with scavenger receptor class B, type I (SR-BI) in a complex fashion, and decreasing interaction with low-density lipoprotein receptor. Despite intensive efforts this modulation of receptor interactions by HVR1 remains incompletely understood. SR-BI has received the most attention and it appears that HVR1 is involved in a multimodal HCV/SR-BI interaction involving high-density-lipoprotein associated ApoCI, which may prime the virus for later entry events by exposing conserved NAb epitopes, like those in the CD81 binding site. To fully elucidate the multifunctional role of HVR1 in HCV entry and NAb evasion, improved E1/E2 models and comparative studies with other NAb evasion strategies are needed. Derived knowledge may be instrumental in the development of a prophylactic HCV vaccine.
LOBO: Evaluation of Generalization Deficiencies in Twitter Bot Classifiers

Botnets in online social networks are increasingly often affecting the regular flow of discussion, attacking regular users and their posts, spamming them with irrelevant or offensive content, and even manipulating the popularity of messages and accounts. Researchers and cybercriminals are involved in an arms race, and new and updated botnets designed to defeat current detection systems are constantly developed, rendering such detection systems obsolete. In this paper, we motivate the need for a generalized evaluation in Twitter bot detection and propose a methodology to evaluate bot classifiers by testing them on unseen bot classes. We show that this methodology is empirically robust, using bot classes of varying sizes and characteristics and reaching similar results, and argue that methods trained and tested on single bot classes or datasets might not able to generalize to new bot classes. We train one such classifier on over 200,000 data points and show that it achieves over 97% accuracy. The data used to train and test this classifier includes some of the largest and most varied collections of bots used in literature. We then test this theoretically sound classifier using our methodology, highlighting that it does not generalize well to unseen bot classes. Finally, we discuss the implications of our results, and reasons why some bot classes are easier and faster to detect than others.
Association between physician US News & World Report medical school ranking and patient outcomes and costs of care: observational study

Abstract Objective To investigate whether the US News & World Report (USNWR) ranking of the medical school a physician attended is associated with patient outcomes and healthcare spending. Design Observational study. Setting Medicare, 2011-15. Participants 20% random sample of Medicare fee-for-service beneficiaries aged 65 years or older (n=996 212), who were admitted as an emergency to hospital with a medical condition and treated by general internists. Main outcome measures Association between the USNWR ranking of the medical school a physician attended and the physician’s patient outcomes (30 day mortality and 30 day readmission rates) and Medicare Part B spending, adjusted for patient and physician characteristics and hospital fixed effects (which effectively compared physicians practicing within the same hospital). A sensitivity analysis employed a natural experiment by focusing on patients treated by hospitalists, because patients are plausibly randomly assigned to hospitalists based on their specific work schedules. Alternative rankings of medical schools based on social mission score or National Institute of Health (NIH) funding were also investigated. Results 996 212 admissions treated by 30 322 physicians were examined for the analysis of mortality. When using USNWR primary care rankings, physicians who graduated from higher ranked schools had slightly lower 30 day readmission rates (adjusted rate 15.7% for top 10 schools v 16.1% for schools ranked ≥50; adjusted risk difference 0.4%, 95% confidence interval 0.1% to 0.8%; P for trend=0.005) and lower spending (adjusted Part B spending $1029 (£790; €881) v $1066; adjusted difference $36, 95% confidence interval $20 to $52; P for trend <0.001) compared with graduates of lower ranked schools, but no difference in 30 day mortality. When using USNWR research rankings, physicians graduating from higher ranked schools had slightly lower healthcare spending than graduates from lower ranked schools, but no differences in patient mortality or readmissions. A sensitivity analysis restricted to patients treated by hospitalists yielded similar findings. Little or no relation was found between alternative rankings (based on social mission score or NIH funding) and patient outcomes or costs of care. Conclusions Overall, little or no relation was found between the USNWR ranking of the medical school from which a physician graduated and subsequent patient mortality or readmission rates. Physicians who graduated from highly ranked medical schools had slightly lower spending than graduates of lower ranked schools.
The Association of Severe Diabetic Retinopathy With Cardiovascular Outcomes in Long-standing Type 1 Diabetes: A Longitudinal Follow-up

OBJECTIVE It is well established that diabetic nephropathy increases the risk of cardiovascular disease (CVD), but how severe diabetic retinopathy (SDR) impacts this risk has yet to be determined. RESEARCH DESIGN AND METHODS The cumulative incidence of various CVD events, including coronary heart disease (CHD), peripheral artery disease (PAD), and stroke, retrieved from registries, was evaluated in 1,683 individuals with at least a 30-year duration of type 1 diabetes drawn from the Finnish Diabetic Nephropathy Study (FinnDiane). The individuals were divided into four groups according to the presence of diabetic kidney disease (DKD) and/or SDR (+DKD/+SDR, +DKD/−SDR, −DKD/+SDR, and −DKD/−SDR) at baseline visit. Furthermore, age-specific incidences were compared with 4,016 control subjects without diabetes. SDR was defined as laser photocoagulation and DKD as estimated glomerular filtration rate <60 mL/min/1.73 m2. RESULTS During 12,872 person-years of follow-up, 416 incident CVD events occurred. Even in the absence of DKD, SDR increased the risk of any CVD (hazard ratio 1.46 [95% CI 1.11–1.92]; P < 0.01), after adjustment for diabetes duration, age at diabetes onset, sex, smoking, blood pressure, waist-to-hip ratio, history of hypoglycemia, and serum lipids. In particular, SDR alone was associated with the risk of PAD (1.90 [1.13–3.17]; P < 0.05) and CHD (1.50 [1.09–2.07; P < 0.05) but not with any stroke. Moreover, DKD increased the CVD risk further (2.85 [2.13–3.81]; P < 0.001). However, the risk was above that of the control subjects without diabetes also in patients without microvascular complications, until the patients reached their seventies. CONCLUSIONS SDR alone, even without DKD, increases cardiovascular risk, particularly for PAD, independently of common cardiovascular risk factors in long-standing type 1 diabetes. More remains to be done to fully understand the link between SDR and CVD. This knowledge could help combat the enhanced cardiovascular risk beyond currently available regimens.
WDFY4 Is Involved in Symptoms of Systemic Lupus Erythematosus by Modulating B Cell Fate via Noncanonical Autophagy

Genome-wide association studies have recently illuminated that WDFY4 is genetically associated with systemic lupus erythematosus (SLE) susceptibility in various ethnic groups. Despite strong genetic evidence suggesting a role of WDFY4 in SLE pathogenesis, its functional relevance is largely unknown. In this study, we generated Wdfy4 B lymphocyte conditional knockout (Wdfy4-CKO) mice and found that loss of Wdfy4 led to a decrease in number of total B cells and several subpopulations of B cells in the periphery and a defect in the transition from the pro– to pre–B cell stage in bone marrow. Also, Wdfy4-CKO mice showed impaired Ab responses as compared with controls when challenged with Ag. SLE phenotypes were effectively alleviated in Wdfy4-CKO mice, with significantly diminished pristane-elicited production of autoantibodies and glomerulonephritis. Genetic silencing of WDFY4 in B cells increased lipidation of LC3 independent of p62 and Beclin1, which are essential proteins of canonical autophagy. Our in vivo and in vitro data suggest that WDFY4 facilitates noncanonical autophagic activity. Our findings provide a novel functional link underlying the mechanism of SLE in which WDFY4 influences B cell fate via noncanonical autophagy.
Characterization of protein isolate from Sesamum indicum seed: In vitro protein digestibility, amino acid profile, and some functional properties

Abstract This work evaluated the impacts of pH and sodium chloride (NaCl) concentration on some functional properties, in vitro protein digestibility, and amino acid profile of sesame (Sesamum indicum) protein isolate (SPI) produced using simultaneous recovery of protein and oil technique. The emulsion activity index (EAI), foam capacity (FC), and protein solubility varied with pH and ionic ability. Foam capacity rose with an increase in ionic strength. Protein solubility ranged from 8.39% at pH 4 to 55.08% at pH 10. In vitro protein digestibility of the SPI with pepsin–pancreatin enzyme systems was 89.57%. Amino acid profile showed that essential amino acids constituted 39.48%. The amino acids had good scores well above 50%. The results showed that SPI extracted by aqueous technique could be used as food ingredient, particularly as thickener, binder, and ingredient in baked food products.