Miracle-dz/UniFAR-FTUs huggingface dataset:
B-HoD: A lightweight and fast binary descriptor for 3D object recognition and registration

3D object recognition and registration in computer vision applications has lately drawn much attention as it is capable of superior performance compared to its 2D counterpart. Although a number of high performing solutions do exist, it is still challenging to further reduce processing time and memory requirements to meet the needs of time critical applications. In this paper we propose an extension of the 3D descriptor Histogram of Distances (HoD) into the binary domain named the Binary-HoD (B-HoD). Our binary quantization procedure along with the proposed preprocessing step reduce an order of magnitude both processing time and memory requirements compared to current state of the art 3D descriptors. Evaluation on two popular low quality datasets shows its promising performance.
Ocean acidification and the Permo-Triassic mass extinction

Ocean acidification and mass extinction The largest mass extinction in Earth's history occurred at the Permian-Triassic boundary 252 million years ago. Several ideas have been proposed for what devastated marine life, but scant direct evidence exists. Clarkson et al. measured boron isotopes across this period as a highly sensitive proxy for seawater pH. It appears that, although the oceans buffered the acidifiying effects of carbon release from contemporary pulses of volcanism, buffering failed when volcanism increased during the formation of the Siberian Traps. The result was a widespread drop in ocean pH and the elimination of shell-forming organisms. Science, this issue p. 229 A rapid injection of massive amounts of carbon into the atmosphere acidified the oceans, causing mass extinction. Ocean acidification triggered by Siberian Trap volcanism was a possible kill mechanism for the Permo-Triassic Boundary mass extinction, but direct evidence for an acidification event is lacking. We present a high-resolution seawater pH record across this interval, using boron isotope data combined with a quantitative modeling approach. In the latest Permian, increased ocean alkalinity primed the Earth system with a low level of atmospheric CO2 and a high ocean buffering capacity. The first phase of extinction was coincident with a slow injection of carbon into the atmosphere, and ocean pH remained stable. During the second extinction pulse, however, a rapid and large injection of carbon caused an abrupt acidification event that drove the preferential loss of heavily calcified marine biota.
High Incidence of Erythromycin Resistance among Clinical Isolates of Streptococcus agalactiae in Taiwan

ABSTRACT The in vitro susceptibilities of 266 isolates ofStreptococcus agalactiae determined by the agar dilution method showed that 6% of isolates were nonsusceptible to penicillin and 46% was resistant to erythromycin. Of the erythromycin-resistant isolates, 86.3% had the macrolide-lincosamide-streptogramin (MLS) resistance phenotype (constitutive MLS, 85.5%; inducible MLS, 0.8%) and 13.7% had the M phenotype.
Multiple layer segmentation and analysis in three-dimensional spectral-domain optical coherence tomography volume scans

Abstract. Spectral-domain optical coherence tomography (SD-OCT) is a three-dimensional imaging technique that allows direct visualization of retinal morphology and architecture. The various retinal layers may be affected differentially by various diseases. An automated graph search algorithm is developed to sequentially segment 11 retinal surfaces in SD-OCT volumes using a three-stage approach. In stage 1, the four most easily discernible and/or distinct surfaces are identified in four-times-downsampled images and are used as a priori information to limit the graph search for the other surfaces in stage 2. Eleven surfaces were then detected in two-times-downsampled images in stage 2, and refined in the original images in stage 3 using the graph search integrating the estimated morphological shape models. Twenty macular SD-OCT volume scans from 20 normal subjects are used in this initial study. The overall mean and absolute mean differences in border positions between the automated and manual segmentation for the 11 surfaces are −0.20±0.53 voxels (−0.76±2.06 μm) and 0.82±0.64 voxels (3.19±2.46 μm), respectively. Intensity/reflectivity and thickness properties in various retinal layers are also investigated. This investigation in normal subjects may provide a comparative reference for subsequent adaptations in eyes with diseases.
Practical Assessment, Research, and Evaluation Practical Assessment, Research, and Evaluation The power of outliers (and why researchers should ALWAYS The power of outliers (and why researchers should ALWAYS check for them) check for them)

There has been much debate in the literature regarding what to do with extreme or influential data points. The goal of this paper is to summarize the various potential causes of extreme scores in a data set (e.g., data recording or entry errors, motivated mis-reporting, sampling errors, and legitimate sampling), how to detect them, and whether they should be removed or not. Another goal of this paper was to explore how significantly a small proportion of outliers can affect even simple analyses. The examples show a strong beneficial effect of removal of extreme scores. Accuracy tended to increase significantly and substantially, and errors of inference tended to drop significantly and substantially once extreme scores were removed.
Promoting the health of looked after children

The Waterhouse report on the widespread abuse of children in care in north Wales from 1974 has focused attention on the issue of how vulnerable such children are to abuse.1 But these children are vulnerable in many ways, not least in terms of their health care, and they are often let down by those who are meant to serve them. The government has been making attempts to improve their overall care and welfare and is currently consulting on improved arrangements for health care. In December 1999 the English Department of Health issued proposed new guidance on the health care of looked after children.2 “Looked after” is the term introduced by the Children Act 1989 to cover all children in public care, including those in foster or residential homes and those still with their own parents but subject to care orders. The new guidance on health care is one of a series of publications that include a revised edition of Working Together to Safeguard Children , 3 which updates the guide to interagency working to promote children's welfare and protect them from abuse, and a new Framework for …
Detection of vascular expression of E-selectin in vivo with MR imaging.

PURPOSE To develop a contrast agent for targeting E-selectin expressed on activated vascular endothelium and to evaluate detection of the agent with magnetic resonance (MR) imaging in an in vivo mouse model of inflammation. MATERIALS AND METHODS All animal experiments were approved according to animal welfare and local ethics committee regulations. An anti-murine E-selectin F(ab')2 monoclonal antibody, MES-1, was conjugated with ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles. Flow cytometry, Perl Prussian blue staining for iron, and MR imaging were performed by using Chinese hamster ovary (CHO) cells expressing mouse E-selectin to detect binding of the conjugate in vitro, and a mouse model of contact hypersensitivity to oxazolone in the ear was used to investigate the in vivo characteristics of the MES-1-USPIO. Serial imaging was performed by using a 9.4-T MR imaging system with a custom receive-only coil. Tissue slices were stained to define distribution of E-selectin expression and localization of the MES-1-USPIO conjugate. RESULTS MES-1-USPIO was shown to bind to CHO cells expressing mouse E-selectin in vitro. After injection of MES-1-USPIO in vivo, distinct changes in R2 relaxation rate (1/T2) characteristics were detected in inflamed ears when they were compared with control ears. Histologic analysis confirmed the vascular endothelial distribution of MES-1-USPIO. CONCLUSION E-selectin expression in vivo can be selectively and directly imaged noninvasively with MR. This has the potential to be useful in the study of inflammatory disease.
Central Differencing Based Numerical Schemes for Hyperbolic Conservation Laws with Relaxation Terms

Many applications involve hyperbolic systems of conservation laws with source terms. The numerical solution of such systems may be challenging, especially when the source terms are stiff. Uniform accuracy with respect to the stiffness parameter is a highly desirable property but it is, in general, very difficult to achieve using underresolved discretizations. For such problems we develop different second order uniformly accurate high-resolution nonoscillatory central schemes. The schemes retain the simplicity of central schemes for hyperbolic conservation laws and avoid the use of Riemann solvers. In particular, we show that these schemes possess a discrete analogue of the continuous asymptotic limit and are able to capture the correct behavior even if the initial layer and the small relaxation time are not numerically resolved.
Respiratory Viral Infections in Developing Countries: Common, Severe, and Unrecognized

annual 36,000 and 11,000 deaths, respectively [4]. Since the discovery of influenza A virus in 1933, ~20 respiratory viruses have been identified. Most acute respiratory infections are caused by rhinovirus, RSV, enteroviruses, influenza A and B viruses, parainfluenza viruses, or adenovirus. During the 21st century, new emerging respiratory viruses have been detected, including severe acute respiratory syndrome coronavirus, human metapneu-
Clinical Significance of Quantifying Pneumocystis jirovecii DNA by Using Real-Time PCR in Bronchoalveolar Lavage Fluid from Immunocompromised Patients

ABSTRACT Quantitative PCR (qPCR) is more sensitive than microscopy for detecting Pneumocystis jirovecii in bronchoalveolar lavage (BAL) fluid. We therefore developed a qPCR assay and compared the results with those of a routine immunofluorescence assay (IFA) and clinical data. The assay included automated DNA extraction, amplification of the mitochondrial large-subunit rRNA gene and an internal control, and quantification of copy numbers with the help of a plasmid clone. We studied 353 consecutive BAL fluids obtained for investigation of unexplained fever and/or pneumonia in 287 immunocompromised patients. No qPCR inhibition was observed. Seventeen (5%) samples were both IFA and qPCR positive, 63 (18%) were IFA negative and qPCR positive, and 273 (77%) were both IFA and qPCR negative. The copy number was significantly higher for IFA-positive/qPCR-positive samples than for IFA-negative/qPCR-positive samples (4.2 ± 1.2 versus 1.1 ± 1.1 log10 copies/μl; P < 10−4). With IFA as the standard, the qPCR assay sensitivity was 100% for ≥2.6 log10 copies/μl and the specificity was 100% for ≥4 log10 copies/μl. Since qPCR results were not available at the time of decision-making, these findings did not trigger cotrimoxazole therapy. Patients with systemic inflammatory diseases and IFA-negative/qPCR-positive BAL fluid had a worse 1-year survival rate than those with IFA-negative/qPCR-negative results (P < 10−3), in contrast with solid-organ transplant recipients (P = 0.88) and patients with hematological malignancy (P = 0.26). Quantifying P. jirovecii DNA in BAL fluids independently of IFA positivity should be incorporated into the investigation of pneumonia in immunocompromised patients. The relevant threshold remains to be determined and may vary according to the underlying disease.
Evaluation of obesity in healthcare workers.

BACKGROUND Obesity is an international social problem. OBJECTIVES This study was aimed at evaluating the relationship of overweight and obesity with social dynamics and correlated biological indicators. SUBJECTS AND METHODS The study was carried out on a group of healthcare workers employed in a large hospital in the province of Messina (Sicily, Italy). A total of 1010 subjects (377 men and 633 women) aged between 16 and 64 years, living in the province of Messina since birth. The educational level, BMI (Body mass index), arterial blood pressure and ECG of each subject was examined. RESULTS The results showed that 52% of the men and 66.5% of the women were of normal weight, while the men showed greater susceptibility to overweight (M 33.2% > F 16%). Obesity was found in both sexes (M 13.3%, F 13.6%). Moreover, it was observed that arterial blood pressure tends to increase with age and body weight, and that the incidence of overweight falls as educational level rises. CONCLUSIONS The study supports the hypothesis that there is a growing incidence of overweight and obesity in subjects of working age employed in the healthcare sector.
Visual outcome in primary macula-off rhegmatogenous retinal detachment treated with scleral buckling.

BACKGROUND AND PURPOSE To evaluate the visual outcome of primary macula-off rhegmatogenous retinal detachment after successful scleral buckling. METHODS A retrospective, non-controlled case series study was conducted in 93 patients (93 eyes) who underwent primary successful scleral buckling procedure for retinal detachment. Factors including duration of macular detachment, patient age, preoperative best-corrected visual acuity (VA), surgical management of subretinal fluid, and refractive error were analyzed statistically to determine their association with final visual outcome. RESULTS Postoperative VA of 20/50 or better was found in 53.6% of eyes with duration of macular detachment within 7 days, and 29.7% of eyes with macular detachment for more than 7 days (Fisher's exact test, p = 0.019). VA better than 20/50 was found in 61% of eyes with preoperative VA better than 20/400 and in 33.9% with preoperative VA worse than 20/400 (Fisher's exact test, p = 0.008). Patients aged 30 years or less achieved better mean postoperative VA than those aged 31 to 50 and those aged 50 years and older (ANOVA, p = 0.003). Patients with low-grade myopia (< -6D) regained significantly better mean postoperative VA as compared with high myopia (> -6D) and emmetropic eyes (0 to +3D) (ANOVA, p < 0.001). Subretinal fluid drainage procedure did not affect postoperative visual result. Multivariate logistic regression analysis revealed that the duration of macular detachment was the only variable affecting the visual result. CONCLUSION Scleral buckle surgery performed within the first week, preoperative vision more than 20/400, age younger than 30 years old, and low-grade myopia were associated with significantly better visual recovery from macular-off rhegmatogenous retinal detachment.
Comparative cognition: Human numerousness judgments

Previous studies regarding numerousness judgments of dot displays showed humans to be accurate to 6 dots and 2 monkeys to be accurate to 8 dots and 1 monkey to 9 dots. However, the monkeys performed numerousness discrimination involving pairs of dot arrays and the humans made absolute numerousness judgments involving as many as 35 dot arrays. With 140 humans we replicated as closely as possible the discrimination method used with monkeys. On the three most difficult tasks, 5 of 20 subjects discriminated 8 versus 9 dots and 2 of 20 discriminated 9 versus 10 and 10 versus 11 dots. There were no significant differences in response time (RT) for successive numerousness pairs and no correlation between mean RT and dot arrays over the range from 3 to 11 dots. Results were discussed in relation to human and nonhuman animal investigations of numerical competence and were considered consistent with a noncounting process interpretation.
Epidermal and Fibroblast Growth Factors Behave as Mitogenic Regulators for a Single Multipotent Stem Cell-Like Population from the Subventricular Region of the Adult Mouse Forebrain

The subventricular zone (SVZ) of the adult mammalian forebrain contains kinetically distinct precursor populations that contribute new neurons to the olfactory bulb. Because among forebrain precursors there are stem-like cells that can be cultured in the presence of mitogens such as epidermal growth factor (EGF) and fibroblast growth factor 2 (FGF2), we asked whether distinct subsets of stem-like cells coexist within the SVZ or whether the proliferation of a single type of SVZ stem-like cell is controlled by several GFs. We show that the latter is the case. Thus cells isolated from the SVZ coexpress the EGF and FGF receptors; by quantitative analysis, the number of stem-like cells isolated from the SVZ by either FGF2 or EGF is the same, whereas no additive effect occurs when these factors are used together. Furthermore, short-term administration of high-dose [3H]thymidine in vivo depletes both the EGF- and FGF2-responsive stem-like cell populations equally, showing they possess closely similar proliferation kinetics and likely belong to the constitutively proliferating SVZ compartment. By subcloning and population analysis, we demonstrate that responsiveness to more than one GF endows SVZ cells with an essential stem cell feature, the ability to vary self-renewal, that was until now undocumented in CNS stem-like cells. The multipotent stem cell-like population that expands slowly in the presence of FGF2 in culture switches to a faster growth mode when exposed to EGF alone and expands even faster when exposed to both GFs together. Analogous responses are observed when the GFs are used in the reverse order, and furthermore, these growth rate modifications are fully reversible.
Phylogeography of the sergeants Abudefduf sexfasciatus and A. vaigiensis reveals complex introgression patterns between two widespread and sympatric Indo‐West Pacific reef fishes

On evolutionary timescales, sea level oscillations lead to recurrent spatio‐temporal variation in species distribution and population connectivity. In this situation, applying classical concepts of biogeography is challenging yet necessary to understand the mechanisms underlying biodiversity in highly diverse marine ecosystems such as coral reefs. We aimed at studying the outcomes of such complex biogeographic dynamics on reproductive isolation by sampling populations across a wide spatial range of a species‐rich fish genus: the sergeants (Pomacentridae: Abudefduf). We generated a mutlilocus data set that included ten morpho‐species from 32 Indo‐West Pacific localities. We observed a pattern of mito‐nuclear discordance in two common and widely distributed species: Abudefduf sexfasciatus and Abudefduf vaigiensis. The results showed three regional sublineages (Indian Ocean, Coral Triangle region, western Pacific) in A. sexfasciatus (0.6–1.5% divergence at cytb). The other species, A. vaigiensis, is polyphyletic and consists of three distinct genetic lineages (A, B and C) (9% divergence at cytb) whose geographic ranges overlap. Although A. vaigiensis A and A. sexfasciatus were found to be distinct based on nuclear information, A. vaigiensis A was found to be nested within A. sexfasciatus in the mitochondrial gene tree. A. sexfasciatus from the Coral Triangle region and A. vaigiensis A were not differentiated from each other at the mitochondrial locus. We then used coalescent‐based simulation to characterize a spatially widespread but weak gene flow between the two species. We showed that these fishes are good candidates to investigate the evolutionary complexity of the discrepancies between phenotypic and genetic similarity in closely related species.
The Multidimensional Work Motivation Scale: Validation evidence in seven languages and nine countries

Self-determination theory proposes a multidimensional conceptualization of motivation comprising autonomous and controlled forms. Whereas autonomous motivation relates positively to individuals’ optimal functioning (e.g., well-being, performance), controlled motivation is less beneficial. To be able to use self-determination theory in the field of organizational behaviour, the Multidimensional Work Motivation Scale was developed and tested using data from 3435 workers in seven languages and nine countries. Factorial analyses indicated that the 19-item scale has the same factor structure across the seven languages. Convergent and discriminant validity tests across the countries also indicate that the psychological needs for autonomy, competence, and relatedness as well as the theoretically derived antecedents to work motivation (e.g., leadership and job design) are predictably related to the different forms of motivation, which in turn are predictably related to important work outcomes (e.g., well-being, commitment, performance, and turnover intentions). Implications for the development of organizational research based on self-determination theory are discussed.
An Assessment of the Effects of Hydrotherapy During the Active Phase of Labor on the Labor Process and Parenting Behavior

This study was conducted to assess the effect on labor process and parenting behavior of hydrotherapy applied during the active phase of labor. This quasi-experimental study was conducted by using an equivalent comparison group (n = 40). The participants in the experimental group whose cervical dilation was 5 cm were taken to the hydrotherapy tub. This application continued until cervical dilation reached 10 cm. The Participants Questionnaire, The Birth Follow-up Questionnaire, The Postpartum ]collection tools. The duration of the active phase and second stage of labor was extremely short in the experimental group in comparison with the equivalent comparison group (p = .001). The Visual Analogue Scale (VAS) scores of the experimental group were lower than those of the equivalent comparison group when cervical dilation was 6 cm and 10 cm (p = .001). The experimental group also displayed more positive parenting behavior and positive labor feeling (p = .001).
Length of stay: prediction and explanation.

Abstract Five methodologies for predicting hospital length of stay were developed and compared. Two—a subjective Bayesian forecaster and a regression forecaster—also measured the relative importance of the symptomatic and demographic factors in predicting length of stay. The performance of the methodologies was evaluated with several criteria of effectiveness and one of cost. The results should provide encouragement for those interested in computer applications to utilization review and to scheduling inpatient admissions.
The role of the house in early Neolithic Ireland

The focus of this article is the use and abandonment of the rectangular timber buildings of the Irish early Neolithic, a period that corresponds roughly with the first half of the fourth millennium cal BC. While they do not represent the only remains of occupation at this time, the fact that they display a striking degree of homogeneity of size, shape and materials makes them an especially interesting part of settlement activity on the island. One particular feature of this patterning is the frequency with which early Neolithic timber buildings have been substantially or completely destroyed by fire. It will be argued below that this burning was deliberate and played an important role in the lifecycle – the creation, maintenance and destruction – of these buildings. To provide a context for this discussion, a more in-depth look will be taken at these distinctive buildings and at their form and function.