Miracle-dz/UniFAR-FTUs huggingface dataset:
Induction of DNA Hydroxymethylation Protects the Brain After Stroke.

Background and Purpose- Epigenetics play a significant role in brain pathologies. We currently evaluated the role of a recently discovered brain-enriched epigenetic modification known as 5-hydroxymethylcytosine (5hmC) in regulating transcriptomic and pathogenic mechanisms after focal ischemic injury. Methods- Young and aged male and female mice were subjected to transient middle cerebral artery occlusion, and the peri-infarct region was analyzed at various times of reperfusion. Two days before middle cerebral artery occlusion, short-interfering RNA against an isoform of the 5hmC producing enzyme TET (ten-eleven translocase) was injected intracerebrally. Ascorbate was injected intraperitoneally at 5 minutes, 30 minutes, or 2 hours of reperfusion. Motor function was tested with rotarod and beam-walk test. Results- Focal ischemia rapidly induced the activity of TET, the enzyme that catalyzes the formation of 5hmC and preferentially increased expression of the TET3 isoform in the peri-infarct region of the ischemic cortex. Levels of 5hmC were increased in a TET3-dependent manner, and inhibition of TET3 led to wide-scale reductions in the postischemic expression of neuroprotective genes involved in antioxidant defense and DNA repair. TET3 knockdown in adult male and female mice further increased brain degeneration after focal ischemia, demonstrating a role for TET3 and 5hmC in endogenous protection against stroke. Ascorbate treatment after focal ischemia enhanced TET3 activity and 5hmC enrichment in the peri-infarct region. TET3 activation by ascorbate provided robust protection against ischemic injury in young and aged mice of both sexes. Moreover, ascorbate treatment improved motor function recovery in both male and female mice. Conclusions- Collectively, these results indicate the potential of TET3 and 5hmC as novel stroke therapeutic targets.
Ultrasonographic optic nerve sheath diameter correlation with ICP and accuracy as a tool for noninvasive surrogate ICP measurement in patients with decompressive craniotomy.

OBJECTIVE Increased intracranial pressure (ICP) results in enlarged optic nerve sheath diameter (ONSD). In this study the authors aimed to assess the association of ONSD and ICP in severe traumatic brain injury (TBI) after decompressive craniotomy (DC). METHODS ONSDs were measured by ocular ultrasonography in 40 healthy control adults. ICPs were monitored invasively with a microsensor at 6 hours and 24 hours after DC operation in 35 TBI patients. ONSDs were measured at the same time in these patients. Patients were assigned to 3 groups according to ICP levels, including normal (ICP ≤ 13 mm Hg), mildly elevated (ICP = 14-22 mm Hg), and severely elevated (ICP > 22 mm Hg) groups. ONSDs were compared between healthy control adults and TBI cases with DC. Then, the association of ONSD with ICP was analyzed using Pearson's correlation coefficient, linear regression analysis, and receiver operator characteristic curves. RESULTS Seventy ICP measurements were obtained among 35 TBI patients after DC, including 25, 27, and 18 measurements in the normal, mildly elevated, and severely elevated ICP groups, respectively. Mean ONSDs were 4.09 ± 0.38 mm in the control group and 4.92 ± 0.37, 5.77 ± 0.41, and 6.52 ± 0.44 mm in the normal, mildly elevated, and severely elevated ICP groups, respectively (p < 0.001). A significant linear correlation was found between ONSD and ICP (r = 0.771, p < 0.0001). Enlarged ONSD was a robust predictor of elevated ICP. With an ONSD cutoff of 5.48 mm (ICP > 13 mm Hg), sensitivity and specificity were 91.1% and 88.0%, respectively; a cutoff of 5.83 mm (ICP > 22 mm Hg) yielded sensitivity and specificity of 94.4% and 81.0%, respectively. CONCLUSIONS Ultrasonographic ONSD is strongly correlated with invasive ICP measurements and may serve as a sensitive and noninvasive method for detecting elevated ICP in TBI patients after DC.
Minimally invasive surgery for radical hysterectomy in women with cervical cancer: Korean Society of Gynecologic Oncology, Korean Society of Obstetrics and Gynecology, and Korean Society of Gynecologic Endoscopy and Minimally Invasive Surgery position statement

On the basis of emerging data and the current understanding of minimally invasive surgery (MIS) for radical hysterectomy (RH) in women with cervical cancer, the Korean Society of Gynecologic Oncology, Korean Society of Obstetrics and Gynecology, and Korean Society of Gynecologic Endoscopy and Minimally Invasive Surgery support the following recommendations: • According to the recently published phase III Laparoscopic Approach to Cervical Cancer (LACC) trial—a prospective randomized clinical trial—disease-free survival and overall survival rates of MIS RH are significantly lower than those of open RH. • Gynecologic oncologists should be aware of the emerging data on MIS RH for early-stage cervical cancer. • The results of the LACC trial, together with institutional data, should be discussed with patients before choosing MIS RH. • MIS RH should be performed for optimal candidates according to the current practice guidelines by gynecologic oncologists who are skilled at performing MIS.
"A lot of us have a very difficult time reconciling what being Muslim is": A phenomenological study on the meaning of being Muslim American.

OBJECTIVES Little is known about the lived experiences of Muslim Americans and what it means to identify as "Muslim American" within the sociopolitical context of Islamophobia. Although xenophobia, racism, and religious discrimination have been shown to impact identity development, it is unclear how Muslim American youth negotiate and make sense of their identities against this backdrop. METHOD A qualitative, phenomenological approach guided the research design to explore how 11 Muslim American late adolescents/emerging adults make sense of their Muslim American identities. Using Critical Race Theory (CRT) and Social Identity Theory (SIT) to guide this investigation, we sought to explore the narratives of what it means to be members of the Muslim American community and how participants experienced cultural belongingness. RESULTS Participants identified four key components that are central to their essence of being Muslim American. These elements were, having (a) a "built-in community," (b) "a lot of ethnic diversity," (c) "a religious practice," and (d) "a feeling that we all have to be this very united group. " CONCLUSIONS Our findings capture the complexities of what it means to be Muslim American, particularly given the heterogeneity within the community. Islamophobia contextualized their meaning-making process by perpetuating group homogeneity as the problem and solution. Clinical and research implications highlight the need to recognize intersectionality and systemic oppression as part of the identity negotiation. Pressures from within and outside of the community converged to impede participants' feelings of cultural belongingness and identity exploration. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
Improving detection of low SNR targets using moment-based detection

Increases in the number of cameras deployed, frame rate, and detector array sizes have led to a dramatic increase in the volume of motion imagery data that is collected. Without a corresponding increase in analytical manpower, much of the data is not analyzed to full potential. This creates a need for fast, automated, and robust methods for detecting signals of interest. Current approaches fall into two categories: detect-before-track (DBT), which are fast but often poor at detecting dim targets, and track-before-detect (TBD) methods which can offer better performance but are typically much slower. This research seeks to contribute to the near real time detection of low SNR, unresolved moving targets through an extension of earlier work on higher order moments anomaly detection, a method that exploits both spatial and temporal information but is still computationally efficient and massively parallelizable. It was found that intelligent selection of parameters can improve probability of detection by as much as 25% compared to earlier work with higherorder moments. The present method can reduce detection thresholds by 40% compared to the Reed-Xiaoli anomaly detector for low SNR targets (for a given probability of detection and false alarm).
X-ray and Gamma-ray Observations of the Fermi Bubbles and NPS/Loop I Structures

The Fermi bubbles were possibly created by large injections of energy into the Galactic Center (GC), either by an active galactic nucleus (AGN) or by nuclear starburst more than ~10 Myr ago. However, the origin of the diffuse gamma-ray emission associated with Loop I, a radio continuum loop spanning across 100 deg on the sky, is still being debated. The northern-most part of Loop I, known as the North Polar Spur (NPS), is the brightest arm and is even clearly visible in the ROSAT X-ray sky map. In this paper, we present a comprehensive review on the X-ray observations of the Fermi bubbles and their possible association with the NPS and Loop I structures. Using uniform analysis of archival Suzaku and Swift data, we show that X-ray plasma with kT ~ 0.3 keV and low metal abundance (Z ~ 0.2 Z_solar) is ubiquitous in both the bubbles and Loop I and is naturally interpreted as weakly shock-heated Galactic halo gas. However, the observed asymmetry of the X-ray-emitting gas above and below the GC has still not been resolved; it cannot be fully explained by the inclination of the axis of the Fermi bubbles to the Galactic disk normal. We argue that the NPS and Loop I may be asymmetric remnants of a large explosion that occurred before the event that created the Fermi bubbles, and that the soft gamma-ray emission from Loop I may be due to either pi^0 decay of accelerated protons or electron bremsstrahlung.
Sphingomyelin in Brain and Cognitive Development: Preliminary Data

Abstract Sphingomyelin (SM) supports brain myelination, a process closely associated with cognitive maturation. The presence of SM in breast milk suggests a role in infant nutrition; however, little is known about SM contribution to healthy cognitive development. We investigated the link between early life dietary SM, later cognitive development and myelination using an exploratory observational study of neurotypical children. SM levels were quantified in infant nutrition products fed in the first three months of life and associated with myelin content (brain MRI) as well as cognitive development (Mullen scales of early learning; MSEL). Higher levels of SM were significantly associated with higher rates of change in verbal development in the first two years of life (r = 0.65, p < 0.001), as well as, higher levels of myelin content at 12–24 months, delayed onset and/or more prolonged rates of myelination in different brain areas. Second, we explored mechanisms of action using in vitro models (Sprague Dawley rat pups). In vitro data showed SM treatment resulted in increased proliferation [p = 0.0133 and p = 0.0434 at 4 and 10 d in vitro (DIV)], maturation (p = 0.467 at 4 d DIV) and differentiation (p = 0.0123 and p = 0.0369 at 4 and 10 DIV) of oligodendrocyte precursor cells (OPCs), as well as increased axon myelination (p = 0.0005 at 32 DIV). These findings indicate an impact of dietary SM on cognitive development in healthy children, potentially modulated by oligodendrocytes and increased axon myelination. Future research should include randomized controlled trials to substantiate efficacy of SM for cognitive benefits together with preclinical studies examining SM bioavailability and brain uptake.
Predicting 3-month risk for adolescent suicide attempts among pediatric emergency department patients.

BACKGROUND The incidence of adolescent suicide is rising in the United States, yet we have limited information regarding short-term prediction of suicide attempts. Our aim was to identify predictors of suicide attempts within 3-months of an emergency department (ED) visit. METHODS Adolescents, ages 12-17, seeking health care at 13 pediatric EDs (Pediatric Emergency Care Applied Research Network) and one Indian Health Service Hospital in the United States were consecutively recruited. Among 10,664 approached patients, 6,448 (60%) were enrolled and completed a suicide risk survey. A subset of participants (n = 2,897) was assigned to a 3-month telephone follow-up, and 2,104 participants completed this follow-up (73% retention). Our primary outcome was a suicide attempt between the ED visit and 3-month follow-up. RESULTS One hundred four adolescents (4.9%) made a suicide attempt between enrollment and 3-month follow-up. A large number of baseline predictors of suicide attempt were identified in bivariate analyses. The final multivariable model for the full sample included the presence of suicidal ideation during the past week, lifetime severity of suicidal ideation, lifetime history of suicidal behavior, and school connectedness. For the subgroup of adolescents who did not report recent suicidal ideation at baseline, the final model included only lifetime severity of suicidal ideation and social connectedness. Among males, the final model included only lifetime severity of suicidal ideation and past week suicidal ideation. For females, the final model included past week suicidal ideation, lifetime severity of suicidal ideation, number of past-year nonsuicidal self-injury (NSSI) incidents, and social connectedness. CONCLUSIONS Results indicate that the key risk factors for adolescent suicide attempts differ for subgroups of adolescents defined by sex and whether or not they report recent suicidal thoughts. Results also point to the importance of school and social connectedness as protective factors against suicide attempts.
Validation of radiologists’ findings by computer-aided detection (CAD) software in breast cancer detection with automated 3D breast ultrasound: a concept study in implementation of artificial intelligence software

Background Computer-aided detection software for automated breast ultrasound has been shown to have potential in improving the accuracy of radiologists. Alternative ways of implementing computer-aided detection, such as independent validation or preselecting suspicious cases, might also improve radiologists’ accuracy. Purpose To investigate the effect of using computer-aided detection software to improve the performance of radiologists by validating findings reported by radiologists during screening with automated breast ultrasound. Material and Methods Unilateral automated breast ultrasound exams were performed in 120 women with dense breasts that included 60 randomly selected normal exams, 30 exams with benign lesions, and 30 malignant cases (20 mammography-negative). Eight radiologists were instructed to detect breast cancer and rate lesions using BI-RADS and level-of-suspiciousness scores. Computer-aided detection software was used to check the validity of radiologists' findings. Findings found negative by computer-aided detection were not included in the readers’ performance analysis; however, the nature of these findings were further analyzed. The area under the curve and the partial area under the curve for an interval in the range of 80%–100% specificity before and after validation of computer-aided detection were compared. Sensitivity was computed for all readers at a simulation of 90% specificity. Results Partial AUC improved significantly from 0.126 (95% confidence interval [CI] = 0.098–0.153) to 0.142 (95% CI = 0.115–0.169) (P = 0.037) after computer-aided detection rejected mostly benign lesions and normal tissue scored BI-RADS 3 or 4. The full areas under the curve (0.823 vs. 0.833, respectively) were not significantly different (P = 0.743). Four cancers detected by readers were completely missed by computer-aided detection and four other cancers were detected by both readers and computer-aided detection but falsely rejected due to technical limitations of our implementation of computer-aided detection validation. In this study, validation of computer-aided detection discarded 42.6% of findings that were scored BI-RADS ≥3 by the radiologists, of which 85.5% were non-malignant findings. Conclusion Validation of radiologists’ findings using computer-aided detection software for automated breast ultrasound has the potential to improve the performance of radiologists. Validation of computer-aided detection might be an efficient tool for double-reading strategies by limiting the amount of discordant cases needed to be double-read.
Differential effects of internalizing behaviors on academic functioning for girls versus boys: An analysis of developmental cascades from elementary to high school

Abstract Youth's academic and emotional functioning are closely related, yet little is known about the timing and direction of relationships involving internalizing problems, which are characterized by over control of emotions, anxiety, and depression as well as multiple aspects of academic achievement. This study addresses these gaps using data from the Study of Early Child Care and Youth Development (N = 1,048) to examine the processes by which problems in one domain of functioning lead to problems in another, known as a “cascade effect. ” Results of longitudinal structural equation modeling indicate (a) a direct and indirect negative cascade effect from girls’ internalizing problems to their school achievement in high school, (b) a positive contemporaneous association of 9th grade boys’ internalizing problems with their cognitive achievement; and (c) ways in which demographic characteristics and adolescent social and maturational processes account for variation in functioning yet do not alter the processes by which the emotional and academic functioning interact. Results are discussed with regard to identifiying adolescents’ internalizing problems, gender differences in the effects of internalizing problems on academic functioning, timing of evidence-based interventions, and implications for mental health promotion among girls.
To treat or not to treat? A retrospective multicenter assessment of survival in patients with IDH-mutant low-grade glioma based on adjuvant treatment.

OBJECTIVE The level of evidence for adjuvant treatment of diffuse WHO grade II glioma (low-grade glioma, LGG) is low. In so-called "high-risk" patients most centers currently apply an early aggressive adjuvant treatment after surgery. The aim of this assessment was to compare progression-free survival (PFS) and overall survival (OS) in patients receiving radiation therapy (RT) alone, chemotherapy (CT) alone, or a combined/consecutive RT+CT, with patients receiving no primary adjuvant treatment after surgery. METHODS Based on a retrospective multicenter cohort of 288 patients (≥ 18 years old) with diffuse WHO grade II gliomas, a subgroup analysis of patients with a confirmed isocitrate dehydrogenase (IDH) mutation was performed. The influence of primary adjuvant treatment after surgery on PFS and OS was assessed using Kaplan-Meier estimates and multivariate Cox regression models, including age (≥ 40 years), complete tumor resection (CTR), recurrent surgery, and astrocytoma versus oligodendroglioma. RESULTS One hundred forty-four patients matched the inclusion criteria. Forty patients (27.8%) received adjuvant treatment. The median follow-up duration was 6 years (95% confidence interval 4.8-6.3 years). The median overall PFS was 3.9 years and OS 16.1 years. PFS and OS were significantly longer without adjuvant treatment (p = 0.003). A significant difference in favor of no adjuvant therapy was observed even in high-risk patients (age ≥ 40 years or residual tumor, 3.9 vs 3.1 years, p = 0.025). In the multivariate model (controlled for age, CTR, oligodendroglial diagnosis, and recurrent surgery), patients who received no adjuvant therapy showed a significantly positive influence on PFS (p = 0.030) and OS (p = 0.009) compared to any other adjuvant treatment regimen. This effect was most pronounced if RT+CT was applied (p = 0.004, hazard ratio [HR] 2.7 for PFS, and p = 0.001, HR 20.2 for OS). CTR was independently associated with longer PFS (p = 0.019). Age ≥ 40 years, histopathological diagnosis, and recurrence did not achieve statistical significance. CONCLUSIONS In this series of IDH-mutated LGGs, adjuvant treatment with RT, CT with temozolomide (TMZ), or the combination of both showed no significant advantage in terms of PFS and OS. Even in high-risk patients, the authors observed a similar significantly negative impact of adjuvant treatment on PFS and OS. These results underscore the importance of a CTR in LGG. Whether patients ≥ 40 years old should receive adjuvant treatment despite a CTR should be a matter of debate. A potential tumor dedifferentiation by administration of early TMZ, RT, or RT+CT in IDH-mutated LGG should be considered. However, these data are limited by the retrospective study design and the potentially heterogeneous indication for adjuvant treatment.
Effects of Canagliflozin on Abnormal Liver Function Tests in Patients of Type 2 Diabetes with Non-Alcoholic Fatty Liver Disease.

Introduction Canagliflozin, a second line OHA is well known to reduce weight. Patients of type 2 diabetes with non-alcoholic fatty liver disease (NAFLD) frequently have abnormal liver functions. We evaluated role of canagliflozin in reducing weight and improving liver function tests (LFT) in type 2 diabetes with NAFLD. Aims Effects of canagliflozin on abnormal liver function tests in patients of type 2 diabetes with non-alcoholic fatty liver disease. Methods We selected type 2 diabetes patients who were having comorbid NAFLD with abnormal LFT. Subjects were prescribed canagliflozin in dose of 100mg/ day for 6 months. Dose adjustments of other drugs (oral hypoglycemics agents and insulins) was done to monitor glycemic target. Effects of canagliflozin was observed on LFT, vitals and HbA1c. It was an observational study. Subjects who developed major side effects were excluded and managed. Results One subject was lost to follow up during study and 31 completed the study successfully. Average HbA1c and weight differences were -0·46% and -1·86% respectively. Average ALT reduction was 36 U/L; t= -9·153623, p is < 0·00001. Average AST reduction was 19·0 U/L; t= -8·153600; p is <0·00001. Average GGT reduction was 5·87 U/L; t= -3·286677, p=0·002588. Average ALP reduction was 1·68 U/L; t= -1·295661. p=0·204973. Serum Bilirubin was elevated by 0·04%; t=0·912, p=0·368. With 0·46% reduction in HbA1c there is 37·5% reduction in ALT levels (R=0·1424) and with 1·86% weight reduction there is 37·5% ALT reduction (R=0·3448). Conclusions Canagliflozin controls HbA1c and reduce weight in type 2 diabetes. It also significantly improves LFT in co-morbid NAFLD.
Titanate Nanowires as One-Dimensional Hot Spot Generators for Broadband Au–TiO2 Photocatalysis

Metal–semiconductor nanocomposites have become interesting materials for the development of new photocatalytic hybrids. Along these lines, plasmonic nanoparticles have proven to be particularly efficient photosensitizers due to their ability to transfer plasmonic hot electrons onto large bandgap semiconductors such as TiO2, thus extending the activity of the latter into a broader range of the electromagnetic spectrum. The extent of this photosensitization process can be substantially enhanced in those geometries in which high electromagnetic fields are created at the metal–semiconductor interface. In this manner, the formation of plasmonic hot spots can be used as a versatile tool to engineer the photosensitization process in this family of hybrid materials. Herein, we introduce the use of titanate nanowires as ideal substrates for the assembly of Au nanorods and TiO2 nanoparticles, leading to the formation of robust hybrids with improved photocatalytic properties. Our approach shows that the correct choice of the individual units together with their rational assembly are of paramount importance in the development of complex nanostructures with advanced functionalities.