Miracle-dz/UniFAR-FTUs huggingface dataset:
Scanning laser polarimetry and detection of progression after optic disc hemorrhage in patients with glaucoma.

OBJECTIVE To examine retinal nerve fiber layer changes with scanning laser polarimetry (SLP) in the eyes of patients with glaucoma and optic disc hemorrhage. METHODS Automated perimetry and SLP were performed in 17 eyes of 17 patients identified prospectively with optic disc hemorrhage. Criteria for visual field progression were based on decreased sensitivity seen at 3 adjacent points on the total deviation plot. Progression on SLP images was defined as a 15% or more decrease in the average thickness of the affected quadrant (superior or inferior), a 25% or more reduction in the affected quadrant ratio, an increase in the nerve fiber analyzer number of 10 or more (GDx Nerve Fiber Analyzer; Laser Diagnostic Technologies), or any change on Serial Analysis of the SLP images. MAIN OUTCOME MEASURES Visual field progression and SLP image progression. RESULTS The mean follow-up was 31 months (minimum, 12 months). Of the 17 eyes, 10 (59%) had visual field progression. No significant change was seen on SLP images for either the total group or the group with visual field progression. Five eyes (29%) showed progression on SLP images, 3 of which also showed visual field progression. Ten eyes showed progression on SLP images that was not confirmed on subsequent imaging. CONCLUSIONS In eyes with visual field progression after optic disc hemorrhage, a significant change in the SLP image was not seen. Fluctuation of SLP results in patients with glaucoma necessitates confirmation of progression seen on SLP images.
A DC offset-free ultra-wideband direct conversion receiver based on photonics

A demonstrator of DC offset-free direct conversion receiver is presented. The innovative architecture exploits optical domain up-conversion and photonic I/Q demodulation to perform a wideband scanning of the RF input spectrum avoiding bulky multiple crystal oscillators and bandpass filters. Moreover, the scheme provides a total immunity to local oscillator self-mixing and to RF-to-baseband feedthrough. The demonstrator achieves a measured DC offset lower than 50 μν and a second-order input-intercept point of 57 dBm. It also shows an operating and instantaneous bandwidth of 0.5÷10.5 GHz and 1 GHz, respectively, with linear dynamic range of 160 dB/Hz and spurious-free dynamic range of 109 dB/Hz2/3, outperforming current pure electronic direct conversion receivers. Further improvements are proposed to enhance the operating bandwidth and to reduce the size and power consumption, making the proposed direct conversion receiver suitable for practical electronic warfare applications.
The contribution of star-forming galaxies to the cosmic radio background

Recent measurements of the temperature of the sky in the radio band, combined with literature data, have convincingly shown the existence of a cosmic radio background with an amplitude of ∼ 1 K at 1 GHz and a spectral energy distribution that is well described by a power law with index � ≃ −0.6. The origin of this signal remains elusive, and it has been speculated that it could be dominated by the contribution of star-forming galaxies at high redshift if the far infrared-radio correlation q(z) evolved in time. We fit observational data from several different experiments by the relation q(z) ≃ q0 − � log(1 + z) with q0 = 2.783 ± 0.024 and � = 0.705 ± 0.081 and estimate the total radio emission of the whole galaxy population at any given redshift from the cosmic star formation rate density at that redshift. It is found that star-forming galaxies can only account for ∼13 percent of the observed intensity of the cosmic radio background.
Responses of pre- and post-menopausal females to aerobic conditioning.

This study sought to determine whether the ability to improve cardiorespiratory endurance and body composition is affected by the menopausal status of females. Twenty premenopausal females and 18 postmenopausal females, ages 35-49 and 47-66 yr, respectively, were randomly assigned to exercise and control groups depending on menopausal status. Both exercise groups (PRE-EX, N = 16; POST-EN, N = 14) participated in a progressive walking program (4 days/week for 9 weeks) at an intensity of 80% the age-adjusted heart rate maximum (80% HRM). Following training, both exercise groups significantly improved submaximal exercise capacity (SEC) as measured by oxygen consumption (l/min; ml/kg . min) and treadmill walking time at 80% HRM. The PRE-EX group significantly improved percent body fat and lean body weight, while there was no significant change in total body weight. The POST-EX group significantly improved total body weight and percent body fat with no significant change in lean body weight. Although some of these changes in body composition were statistically significant, overall the alterations were minimal. ANCOVA revealed exercise, not menopause, to be the effective treatment for improving percent body fat and SEC80%HRM. There were no significant differences between the PRE-EX and POST-EX groups in their ability to improve SEC80%HRM or to reduce percent body fat. The POST-EX group had a significantly greater reduction in total body weight, while the PRE-EX group had significantly greater increases in lean body weight. These findings suggest that the ability to favorably alter body composition and cardiorespiratory endurance through the aerobic conditioning of females is independent of menopausal status.
Relapse Prevention and the Five Rules of Recovery

There are four main ideas in relapse prevention. First, relapse is a gradual process with distinct stages. The goal of treatment is to help individuals recognize the early stages, in which the chances of success are greatest. Second, recovery is a process of personal growth with developmental milestones. Each stage of recovery has its own risks of relapse. Third, the main tools of relapse prevention are cognitive therapy and mind-body relaxation, which are used to develop healthy coping skills. Fourth, most relapses can be explained in terms of a few basic rules. Educating clients in these rules can help them focus on what is important: 1) change your life (recovery involves creating a new life where it is easier to not use); 2) be completely honest; 3) ask for help; 4) practice self-care; and 5) don’t bend the rules.
Relationship between serum adiponectin with anthropometrical and lipid profile biochemical indexes in obese adult men

Background and objective: This study was conducting aimed at comparing adiponectin serum levels in obese male adults with their peer normal weight subjects as well as determining the relationship between anthropometrical and lipid profile indices and serum adiponectin in obese men. Material and methods: Body mass index and other anthropometrical variables as well as concentrations of glucose, triglyceride, total cholesterol and low and high density lipoprotein were measured in 45 obese male adults after 12 to 14 hours overnight fasting and their correlation with serum adiponectin levels were determined. Also, fasting serum adiponectin levels were measured in 35 male adults with normal weight. T statistical method was used to compare adiponectin levels of obese group with normal weight group and regression analysis was used in SPSS software version 15 environment to determine the relationship of adiponectin with each anthropometrical and biochemical variables in obese subjects (P ≤ 0.05). Results: adiponectin Serum level in obese subjects were significantly lower than those with normal weight (P = 0.021). Adiponectin level had a significant correlation with total cholesterol, low density lipoprotein, glucose, and systolic and diastolic blood pressure and age of subjects (P ≤ 0.05). Conclusion: The significant relationship between adiponectin and some cardiovascular risk factors in this study supports the hypothesis that reduction of systemic levels of this hormone is associated with some cardiovascular risk factors.
An economic value analysis on the evolution path of portable internet service: is voice better than broadcast as integrated service?

Measuring the economic value of Portable Internet Service not only helps with the pricing of Portable Internet Service, but also can provide explicitly important information for sketching out its development path for service providers in future. The results of this study indicate that the economic value of a Portable Internet Service according to the current technological standards is in the range of 34,000 won to 75,000 won monthly, depending on the methods of measurement used. The most conservative estimation from the analysis suggests that the appropriate monthly fee for Portable Internet Service must range from 30,000 won to 35,000 won. This, in other words, means that in order to provide economic satisfaction to Portable Internet Service users, the service must be priced in the range of 30,000 won monthly. As for converged Portable Internet Services, bundling Portable Internet Service with voice, or Portable Internet Service with DMB service, the economic value difference between two integrated services is measured at 250 won to 9,000 won monthly. In the meantime, an examination of the development path of Portable Internet Service business in relation to integrated services conducted in the context of this study shows that the perceived economic value potentially felt by service users is higher with the combination of Portable Internet Service bundled with voice service than with the combination of Portable Internet Service and DMB service. Therefore, to better exploit the relevant market potential, the appropriate path to be adopted by Portable Internet Service business would seem to be integrating Portable Internet Service with voice communications service at first, rather than with DMB service.
Monitoring the emergence of community transmission of influenza A/H1N1 2009 in England: a cross sectional opportunistic survey of self sampled telephone callers to NHS Direct

Objective To evaluate ascertainment of the onset of community transmission of influenza A/H1N1 2009 (swine flu) in England during the earliest phase of the epidemic through comparing data from two surveillance systems. Design Cross sectional opportunistic survey. Study samples Results from self samples by consenting patients who had called the NHS Direct telephone health line with cold or flu symptoms, or both, and results from Health Protection Agency (HPA) regional microbiology laboratories on patients tested according to the clinical algorithm for the management of suspected cases of swine flu. Setting Six regions of England between 24 May and 30 June 2009. Main outcome measure Proportion of specimens with laboratory evidence of influenza A/H1N1 2009. Results Influenza A/H1N1 2009 infections were detected in 91 (7%) of the 1385 self sampled specimens tested. In addition, eight instances of influenza A/H3 infection and two cases of influenza B infection were detected. The weekly rate of change in the proportions of infected individuals according to self obtained samples closely matched the rate of increase in the proportions of infected people reported by HPA regional laboratories. Comparing the data from both systems showed that local community transmission was occurring in London and the West Midlands once HPA regional laboratories began detecting 100 or more influenza A/H1N1 2009 infections, or a proportion positive of over 20% of those tested, each week. Conclusions Trends in the proportion of patients with influenza A/H1N1 2009 across regions detected through clinical management were mirrored by the proportion of NHS Direct callers with laboratory confirmed infection. The initial concern that information from HPA regional laboratory reports would be too limited because it was based on testing patients with either travel associated risk or who were contacts of other influenza cases was unfounded. Reports from HPA regional laboratories could be used to recognise the extent to which local community transmission was occurring.
Late embryogenesis abundant proteins

Late Embryogenesis Abundant (LEA) proteins accumulate at the onset of seed desiccation and in response to water deficit in vegetative plant tissues. The typical LEA proteins are highly hydrophilic and intrinsically unstructured. They have been classified in different families; each one showing distinctive conserved motifs. In this manuscript we present and discuss some of the recent findings regarding their role in plant adaptation to water deficit, as well as those concerning to their possible function, and how it can be related to their intrinsic structural flexibility.
On the typology of negative concord

This paper has three main points. First, contrary to what is often stated, negative concord is not all that frequent and certainly not the most frequent strategy to express single clausal negation in a clause with an indefinite noun phrase or adverbial in the scope of the negation. Second, the subtype of negative concord called ‘strict negative concord’ is much more frequent than the subtype of ‘non-strict negative concord’. These two claims are based on a worldwide sample of 179 languages. Third, it is argued that non-strict negative concord shows too much variation for it to be seen as the one choice of a two-way split between strict and non-strict negative concord. Given the relative rarity of non-strict negative concord, this claim is not based on the worldwide sample, but on a survey of the research literature.
Conflict in families and the psychological adjustment of preadolescent children.

We examined the cross-sectional association between conflict in families and child psychological adjustment in 72 4th-5th graders. Multiple informants (parents, children, and teachers) assessed conflict and anger in the social climate of the home, marital discord, negative emotional tone in the parent-child relationship, and child adjustment. As predicted, child adjustment was more strongly related to family conflict than to marital discord. There was a stronger association between family conflict and maladjustment in girls. Moreover, the association between a general climate of conflict at home and child maladjustment was independent of anger and discord in the marital or parentchild relationships. During the study of the effects of interpersonal conflict at home, it appears to be important to identify the locus of anger and aggression. Findings suggest that researchers should distinguish between a general climate of conflict in the family and interparental discord. We examined anger and conflict in families and related it to preadolescent children's psychological adjustment. The term conflict is used here to describe behaviors between family members that range from verbal disagreements and criticism to acts of physical aggression. Different theoretical perspectives, such as attachment theory, social learning theory, and cognitive theory, agree that children are placed at increased risk for the development of behavioral and emotional problems by child-rearing environments in which interpersonal relations are characterized by anger and conflict (cf. Grych & Fincham, 1990; Margolin, 1981; Marvin & Stewart, 1990). It is therefore not surprising that adolescents' descriptions of high levels of family conflict have been associated with self-reported distress and psychological symptoms in recent We would like to thank the principals, teachers, parents, and children who participated in the study. We are also grateful to Andy Christensen, Steve Lopez, Gayla Margolin, and three anonymous reviewers for their helpful comments on an earlier draft of this article. Rena L. Repetti's participation in the preparation of this article was supported by a FIRST award R29-48595 from the National Institute of Mental Health. Correspondence concerning this article should be
The effects of carbon disulphide exposure on brain catecholamines in rats

1 . Rats exposed to 2.0 mg/l. carbon disulphide (CS2) in the inspired air for 2 days, 4 h a day, showed a 13% decrease in their brain noradrenaline concentration and a 16% increase in their brain dopamine concentration. 2 . After exposure for 5 or 10 days there was a further decrease in the concentration of noradrenaline in the brain, but brain dopamine returned to the control level. 3 . In animals treated intraperitoneally with 2.0 mg/kg reserpine and exposed 2 and 3 days later to 2.0 mg/1. CS2 for 4 h per day, the brain dopamine concentration showed a 77% increase compared with the unexposed reserpinized animals, but the noradrenaline concentration remained unchanged. 4 . The dopamine concentrations in the adrenals after 10 days' exposure to 2.0 mg/1. CS2 were 67% to 100% higher than in the control animals. In reserpinized rats, 2 days' exposure to CS2 nearly trebled the dopamine content of adrenals. 5 . Exposure to CS2 had no effect on the tyrosine concentration in the brain, and there was no change in the brain monoamine oxidase (MAO) activity. Tyrosine in the brain showed a 30 to 96% increase in concentration and MAO activity, using kynuramine as substrate, showed an approximately 5 % increase 0.5 to 2 h after the subcutaneous administration of 500 mg/kg sodium diethyldithiocarbamate. 6 . CS2 at 10−2m or lower concentrations had no inhibitory effect on the brain MAO activity in vitro. Diethyldithiocarbamate inhibited MAO at 10−2m, but not at 10−3m or lower concentrations.
Penetrance and Phenotype of the Cys433Arg Myocilin Mutation in a Family Pedigree with Primary Open-Angle Glaucoma

PurposeTo evaluate the penetrance and the clinical characteristics of the Cys433Arg myocilin mutation in a family pedigree with primary open-angle glaucoma. Patients and MethodsPrimary open-angle glaucoma was defined as untreated intraocular pressure (IOP) over 24 mmHg, with characteristic optic nerve and visual field glaucomatous damage. Patients with IOP <24 mm Hg who were currently being treated for primary open-angle glaucoma were included as affected individuals. Genomic DNA was collected from peripheral blood. PCR, single-strand conformation polymorphism, and sequencing analyses were performed to identify the presence of the Cys433Arg mutation in family members. ResultsOf the 48 members of this family evaluated, 17 (35%) were found to harbor the Cys433Arg mutation, 9 (53%) of whom were glaucomatous. None of the 31 individuals without the mutation had glaucoma. Among the 9 patients with glaucoma, 5 had undergone surgical procedure to improve IOP control, including all patients older than 40 years of age. The mutation's penetrance was 0% in persons younger than 10 years (0/4), 40% in those 11 to 30 years (2/5), 75% in persons 30 to 40 years (3/4), and 100% in those older than 40 years (4/4). ConclusionThe Cys433Arg mutation in this pedigree was associated with a phenotype characterized by early-onset open-angle glaucoma, which frequently requires surgical intervention and is associated with a high penetrance
Use of adoptive transfer of tumor-infiltrating lymphocytes alone or in combination with cisplatin-containing chemotherapy in patients with epithelial ovarian cancer.

Lymphocytes isolated from fresh human epithelial ovarian tumors can be expanded in the presence of recombinant interleukin-2, and some CD8 antigen-positive lymphocytes can lyse autologous fresh tumor cells. We treated 7 patients with advanced or recurrent epithelial ovarian cancers, using the adoptive transfer of these tumor-infiltrating lymphocytes (TILs) following a single i.v. injection of cyclophosphamide. One case of disappearance (complete response) and 4 cases of greater than 50% decrease of tumor (partial response) were reported (14.3 and 57.1%, respectively). Regression of tumors in the ovary, liver, lung, and lymph node, both primaries and metastases, lasted for 3-5 months. Furthermore, 10 patients were treated alternately with a cisplatin-containing chemotherapeutic regimen and the adoptive transfer of TILs. Seven cases of complete regression and 2 cases of partial regression of cancer were reported. Four of the 7 patients with a complete response have had no recurrence for greater than 15 months of follow-up. It appears that this experimental technique of adoptive transfer of TILs achieves high response rates even without recombinant interleukin-2 administration and that the prospect of combined therapy using TILs and cisplatin offers hope for increasing the cure rate and long-term survival.
MiR-145 regulates hematopoiesis during zebrafish development

MicroRNA-145 (miR-145) is considered to play key role in many cellular processes, such as proliferation, differentiation and apoptosis by inhibiting target gene expression. The transcriptional regulation of cardiovascular development requires precise spatiotemporal control of gene expression. We are beginning to understand the functions of miRNA-145 played during essential biological processes especially erythropoiesis. Here, we overview the recent findings on miRNA-145 regulation in erythropoiesis development and report the latest advances in understanding their function by unveiling their mRNA targets. Further analysis of miRNA-145 function during erythropoiesis development will allow us to determine the potential for novel miRNA-145-based therapeutic strategies. Haematopoiesis is an active process by which peripheral blood families are developed. It is a process strongly regulated by many essential and unessential factors, including signalling molecules and transcriptional factors. However, the epigenetic regulation of haematopoiesis regulation via microRNAs (miRNAs) remains partially understood. Here, in this study we show that miRNA-145 participates in the haematopoiesis regulation and vascular development of the early stages of erythropoiesis during Zebra fish early developmental stages. Overexpression inhibited the primitive haematopoiesis, characterized by a significant reduced number and limitation of erythropoiesis cells and myeloid expansion significantly reduced expression of runx1, c-myb, mpo-1, Scl and pu.1, and significantly reduced o-dianisidine staining of haemoglobin. Systematically, miR-145 regulates haematopoiesis by repressing expression of meis1 involved in haematopoiesis. We performed knock-down analysis of the meis1 gene to check and demonstrate that whether meis1-EGFP is related with our miRNA. Co-injection-confirmation at 24 and 48 hpf pictures analyses showed that overexpression of miR-145 repressed expression of meis1. Bioinformatics analysis predicts a target binding sequence for miR-145 at the 3-UTR of meis1. Deletion of the miR-145 target sequence eliminated the repression of meis1 expression mediated by miR-145. These findings create miR-145 as a novel miRNA that regulates haematopoiesis and vascular development by repressing expression of meis1.
Subcortical Metabolic Alterations in Partial Epilepsy

Summary The function of subcortical nuclei in partial epilepsy was investigated using positron emission tomography (PET) to measure metabolism in the basal ganglia and thalamus. Sixteen patients undergoing surgical evaluation were studied with 18F‐fluorodeoxyglucose (FDG) interictally and had intensive extracranial and intracranial electrophysiologic evaluations. Eight patients had left temporal lobe seizure foci, six had right temporal lobe foci, and two had right posterotemporal or parietal foci. The PET data were analyzed visually and quantitatively, using a multivariate analysis of variance on the quantitative data. Hypometabolism of subcortical nuclei was Present ipsilateral to the cortical seizure focus. Cortical hypometabolism was noted focally in the temporal lobe in patients with left temporal lobe seizure foci, whereas patients with right temporal lobe seizure foci had diffuse hemispheric hypometabolism. We postulate that the subcortical hypometabolism is secondary to decreased efferent activity from temporal lobe structures, in particular amygdala and hippocampus, to subcortical nuclei. Diminished subcortical activity may then lead to defective regulation of cortical excitability in the temporal lobe, increasing the likelihood of seizure development and spread.