Miracle-dz/UniFAR-FTUs huggingface dataset:
Young people’s views on provision of sexual health services

Objectives: To identify the sexual health needs of young people in order to establish a service suited to these needs. Methods: A peer designed questionnaire piloted to a small group of young people was followed by a more widely distributed, amended questionnaire. The questionnaire survey was delivered to 744 pupils aged 11–18 years in six secondary schools and a pupil exclusion unit in central London. Factors encouraging or discouraging the use of young people’s sexual health services were measured. Results: Several findings challenged existing models of care for young people’s sexual health services. Notably, pupils wanted clinics to run more frequently than the usual once a week; the staff attributes that were most important were attitudinal rather than to do with sex, age, or physical appearance; and they did not mind if the waiting room contained older people. Many findings, however, agreed with existing data—young people wanted the clinic to be open after school; girls preferred to attend with a friend; a confidential, walk-in service was preferred. Conclusions: Large financial outlays are not necessary for the establishment of effective sexual health services for young people. Existing facilities and staff may be utilised with training of these staff to be sensitive to, and aware of, the needs of young people. Clinic opening times should coincide with school closing times. Although pupils stated a preference for female staff, this was not a high priority. More important was feeling that staff would listen to them and take their problems seriously, and that confidentiality would be maintained.
Depression and Anxiety in Pain

• Mood disorders, especially depression and anxiety, play an important role in the exacerbation of pain perception in all clinical settings. • Depression commonly occurs as a result of chronic pain and needs treating to improve outcome measures and quality of life. • Anxiety negatively affects thoughts and behaviours which hinders rehabilitation. • Anxiety and depression in acute hospital settings also negatively affect pain experience and should be considered in both adults and children. • Poor pain control and significant mood disorders perioperatively contribute to the development of chronic postoperative pain.
Congenital and neonatal syphilis in guinea-pigs show a different pattern of immune response.

C4-deficient (C4D) and Albany strains of guinea-pigs transplacentally and neonatally infected with Treponema pallidum showed distinctive patterns of humoral immune responses. Congenitally infected progeny of both strains originated from dams intradermally (i.d.) infected at mid-pregnancy with virulent T. pallidum. In the neonatal groups families of C4D and Albany strains consisting of 1-3-day-old offspring and their mothers were i.d. infected with a similar dose of T. pallidum. Regardless of the strain, asymptomatic congenitally infected guinea-pigs (n = 16) responded from the first day of life with high levels of IgM [T. pallidum (TP) ELISA] antitreponemal antibodies and up to 85% presented with IgM CIC (circulating immune complexes) and IgM RF (rheumatoid factor). Although relatively high levels of IgM antitreponemal antibodies persisted in these animals throughout the 4-month experimental period, significant levels of host IgG antitreponemal antibodies were detectable after 2-3 months of age. Neonatally infected guinea-pigs of both strains (n = 27) responded similar to the infected sow but with relatively lower levels of IgM and IgG antitreponemal antibodies at 1 and 4 weeks, respectively, both of which increased with the time of infection. Antibodies were also detected in these animals by fluorescent treponemal antibody adsorption test (FTA-ABS). Unlike congenital syphilis, neonatally infected animals developed IgG-CIC after 2-3 months of infection and none of them showed any RF. In neonatal syphilis, FTA-ABS antibody levels were closely associated with the onset of lesions, whereas those of TP ELISA were not. The distinctive immune responses observed in these experimental models have the potential to differentiate between congenitally and neonatally infected human infants, even though the current clinical management is the same.
A performance‐based method for early identification of medical students at risk of developing academic problems

The authors studied three classes at the Albert Einstein College of Medicine and found that students' performances on examinations administered during the third month (November) of medical school were highly predictive of their subsequent performances during the first two years of medical school. The investigation had two components: (1) a retrospective study of the classes of 1988 and 1989, which found that students' November grades from three first-year courses predicted 76% of the variance in the year-one weighted aggregate score and 41% for the year-two score, and (2) a prospective study of the class of 1992, in which three November of year one examination scores of the students in the lowest quarter of the class were highly predictive of their encountering substantial academic problems, with a sensitivity of . 77 and a specificity of . 99. This performance-based method was found to be more powerful than using the scores on the 1977 version of the Medical College Admission Test or the students' undergraduate grade-point averages, or both, in identifying individual students who were academically at risk.
Muscle tuning during running: implications of an un-tuned landing.

BACKGROUND The impact force in heel-toe running is an input signal into the body that initiates vibrations of the soft tissue compartments of the leg. These vibrations are heavily damped and the paradigm of muscle tuning suggests the body adapts to different input signals to minimize these vibrations. The objectives of the present study were to investigate the implications of not tuning a muscle properly for a landing with a frequency close to the resonance frequency of a soft tissue compartment and to look at the effect of an unexpected surface change on the subsequent step of running. METHOD Thirteen male runners were recruited and performed heel-toe running over two surface conditions. The peak accelerations and biodynamic responses of the soft tissue compartments of the leg along with the EMG activity of related muscles were determined for expected soft, unexpected hard and expected hard landings. RESULTS AND CONCLUSIONS For the unexpected hard landing there was a change in the input frequency of the impact force, shifting it closer to the resonance frequency of the soft tissue compartments. For the unexpected landing there was no muscle adaptation, as subjects did not know the running surface was going to change. In support of the muscle-tuning concept an increase in the soft tissue acceleration did occur. This increase was greater when the proximity of the input signal frequency was closer to the resonance frequency of the soft tissue compartment. Following the unexpected change in the input signal a change in pre-contact muscle activity to minimize soft tissue compartment vibrations was not found. This suggests if muscle tuning does occur it is not a continuous feedback response that occurs with every small change in the landing surface properties. In previous studies with significant adaptation periods to new input signals significant correlations between the changes in the input signal frequency and the EMG intensity have been shown, however, changes in soft tissue accelerations have not been found. The results of the present study showed that changes in these soft tissue accelerations can occur in response to a resonance frequency input signal when a muscle reaction has not happened.
Reduction of switching time in pentalayer magnetic tunnel junctions with a composite‐free layer

We have performed micromagnetic simulations of the magnetization dynamics of the composite‐free magnetic layer in a pentalayer structure. We have found a substantial decrease of the switching time in this system as compared to the pentalayer structure of similar dimensions with a monolithic free layer. The physical reasons for the switching time reduction at the same current density are discussed. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Patient Satisfaction, Hernia Recurrence Rate, and Chronic Pain 10 Years After Endoscopic Total Extraperitoneal Inguinal Hernia Repair

Introduction Long-term outcome data after total endoscopic preperitoneal hernia repair are scarce. This study reports the 10-year results after endoscopic total extraperitoneal hernia repair in terms of recurrence rates and various patient-orientated indicators of quality of life. Methods Between July 1995 and April 2000, 107 consecutive patients underwent endoscopic total extraperitoneal inguinal hernia repair. The follow-up assessment between December 2007 and June 2008 included a clinical examination and a patient questionnaire. Results Sixty-three patients (64.3%) with 108 hernias attended follow-up, an average of 115.7 months (range 91 to 148 mo) after the index operation. The incidence of recurrence was 2.8%, of chronic pain 15.9%, and of foreign body sensation 33.3%. Patient satisfaction measured on the Visual Analogue Scale was high with a median of 9.6 (range 0.3 to 10). Conclusions Endoscopic total extraperitoneal hernia repair is a safe and effective procedure with excellent long-term results and an extremely high rate of patient satisfaction.
Suppression of intracellular Cu‐Zn SOD results in enhanced motility and metastasis of Meth A sarcoma cells

We have previously described an inverse relationship between Cu‐Zn superoxide dismutase (SOD) activity and invasiveness of a clone of human tongue cancer cells. In these cells, suppression of Cu‐Zn SOD activity by transfection with anti‐sense cDNA enhanced motility in vitro. The present studies were undertaken to determine whether the inverse relationship between intracellular Cu‐Zn SOD activity and motility is a general property of other tumor cells and whether this enzyme indeed defines in vivo metastatic potential. Murine Meth A sarcoma‐derived ML‐01 cells, which have low metastatic activity, were transfected with anti‐sense Cu‐Zn SOD cDNA. Two clones with very different SOD activities—ML‐AS2, with the most suppressed, and ML‐AS5, with the least suppressed activity—were analyzed for their motility and metastatic capability. Compared to the mock‐transfectant ML‐neo, the metastatic potential and motility of the ML‐AS2 and ML‐AS5 were increased 4.5‐ and 2.1‐fold, respectively. Superoxide treatment enhanced the motility of the AS clones but not that of the ML‐neo cells. Our results clearly show that there is an inverse relationship between the intracellular level of Cu‐Zn SOD, cell motility and in vivo metastatic potential. Int. J. Cancer 73:187–192, 1997. © 1997 Wiley‐Liss, Inc.
Probabilistic Liquefaction Triggering Based on the Cone Penetration Test

Performance-based earthquake engineering requires a probabilistic treatment of potential failure modes in order to accurately quantify the overall stability of the system. This paper is a summary of the application portions of the probabilistic liquefaction tri ggering correlations proposed recently proposed by Moss and co -workers. To enable probabilistic treatment of liquefaction triggering, the variables comprising the seismic load and the liquefaction resistance were treated as inherently uncertain. Supportin g data from an extensive Cone Penetration Test (CPT)-based liquefaction case history database were used to develop a probabilistic correlation. The methods used to measure the uncertainty of the load and resistance variables, how the interactions of these variables were treated using Bayesian updating, and how reliability analysis was applied to produce curves of equal probability of liquefaction are presented. The normalization for effective overburden stress, the magnitude correlated duration weighting factor, and the non-linear shear mass participation factor used are also discussed.
Effect of pu‐erh tea on body fat and lipid profiles in rats with diet‐induced obesity

The antiobesity and antihyperlipidaemic effects of pu‐erh tea in rats with high fat diet (HFD)‐induced obesity were investigated. Male Sprague‐Dawley rats were randomly divided into five groups and fed varying diets for an 8‐week period: control diet, HFD, and HFD supplemented with low, moderate or high doses of pu‐erh tea extract (0.5 g, 2 g and 4 g/kg BW/day, respectively). Pu‐erh tea significantly reduced the total body weight and the weight of various adipose pads. Pu‐erh tea administration also significantly lowered plasma total cholesterol, triglyceride concentrations and low‐density lipoprotein‐cholesterol levels in rats with HFD‐induced obesity, but did not affect high‐density lipoprotein‐cholesterol levels. Moreover, pu‐erh tea significantly increased lipoprotein lipase, hepatic lipase and hormone‐sensitive lipase activities in epididymal fat tissue in rats with HFD‐induced obesity. Analysis of real‐time reverse transcription‐polymerase chain reaction results indicated that pu‐erh tea significantly enhanced mRNA levels of hormone‐sensitive lipase in rats with HFD‐induced obesity. These results suggest that pu‐erh tea attenuated visceral fat accumulation and improved hyperlipidemia in a rat model of HFD‐induced obesity. Copyright © 2010 John Wiley & Sons, Ltd.
Adaptive Cross-Layer Distributed Energy-Efficient Resource Allocation Algorithms for Wireless Data Networks

The issue of adaptive and distributed cross-layer resource allocation for energy efficiency in uplink code-division multiple-access (CDMA) wireless data networks is addressed. The resource allocation problems are formulated as noncooperative games wherein each terminal seeks to maximize its own energy efficiency, namely, the number of reliably transmitted information symbols per unit of energy used for transmission. The focus of this paper is on the issue of adaptive and distributed implementation of policies arising from this approach, that is, it is assumed that only readily available measurements, such as the received data, are available at the receiver in order to play the considered games. Both single-cell and multicell networks are considered. Stochastic implementations of noncooperative games for power allocation, spreading code allocation, and choice of the uplink (linear) receiver are thus proposed, and analytical results describing the convergence properties of selected stochastic algorithms are also given. Extensive simulation results show that, in many instances of practical interest, the proposed stochastic algorithms approach with satisfactory accuracy the performance of nonadaptive games, whose implementation requires much more prior information.
Safety and Immunogenicity of an Investigational Fully Liquid Hexavalent DTaP-IPV-Hep B-PRP-T Vaccine at Two, Four and Six Months of Age Compared With Licensed Vaccines in Latin America

Objective: This trial assessed the safety of a fully liquid investigational hexavalent DTaP-IPV-Hep B-PRP-T vaccine containing 10 &mgr;g Hansenula polymorpha–derived recombinant hepatitis B (hep B) antigen for primary vaccination of infants at 2, 4 and 6 months of age compared with licensed comparators. Methods: Participants received the DTaP-IPV-Hep B-PRP-T vaccine (group 1, N = 1422) or licensed DTwP-Hep B//Hib (Tritanrix-Hep B/Hib) and oral poliovirus vaccines (group 2, N = 711). The incidence of severe fever (≥39.6°C rectal equivalent) in the 2 groups was compared statistically; reactogenicity was evaluated from parental reports. Anti-Hep B antibody titers were measured in a subset of participants (no hepatitis B vaccination at birth) 1 month after dose 3. Results: The investigational vaccine was well tolerated. After any dose, fever (rectal equivalent temperature ≥38°C) was observed in 74.8% and 92.7% of participants in groups 1 and 2; severe fever was observed in 4.0% and 5.5% of participants. Solicited injection site and systemic reactions were numerically less frequent in group 1 than group 2, although this difference was not assessed statistically. In both groups, all participants included in the immunogenicity analysis achieved anti-Hep B ≥10 mIU/mL and ≥96.2% of participants achieved anti-Hep B ≥100 mIU/mL, although geometric mean titer was approximately 3-fold lower for the investigational vaccine. Conclusion: This new, fully liquid acellular pertussis hexavalent vaccine demonstrated less reactogenicity than the licensed comparator whole cell pertussis vaccine and was highly immunogenic for the new Hep B valence.
TERAPI PUISI: DASAR-DASAR PENGGUNAAN PUISI SEBAGAI MODALITAS DALAM PSIKOTERAPI

Puisi sebagai salah satu bentuk karya sastra dan karya seni memiliki potensi terapeutik tersendiri yang unik. Meskipun belum terlalu dikenal di Indonesia, puisi telah digunakan sebagai sarana penyembuhan diberbagai negara lain, bahkan telah terdapat berbagai asosiasi yang mewadahi terapis puisi ini. Tulisan ini akan memberikan gambaran teoritik mengenai terapi puisi, definisi, sejarah terapi puisi secara singkat, dan letak terapi puisi dalam sistem psikoterapi dan dalam kaitannya dengan beberapa aliran terapi utama.
A modified ring dielectric resonator with improved mode separation in MIC environment

In this paper a novel dielectric resonator structure of modified ring resonator with an improved mode separation simultaneous to no deterioration of Q-factor in the mode of interest is proposed. From the analysis carried out for TEols mode the ring dielectric resonator shape is modified in such a way that the nearest hybrid (or TMOls) modes are pushed farther to provide a high mode separation. The configuration also offers versatility in choosing the substrate thickness which otherwise is limited in a ring resonator
Age-related Marrow Adipogenesis Is Linked to Increased Expression of RANKL*

Background: The osteoclastogenic cytokine RANKL is expressed in various cell types, including osteoblasts, osteocytes, and lymphocytes. Results: RANKL expression is induced during adipogenesis through the action of C/EBPβ and/or C/EBPδ, and RANKL-positive preadipocytes increase in aging marrow along with down-regulation of osteoprotegerin. Conclusion: Adipogenesis is linked to osteoclastogenesis through RANKL expression. Significance: Increased marrow preadipocytes with aging may contribute to osteoporosis. With advancing age bone marrow is progressively replaced with adipose tissue, accompanied by a concomitant decline in bone mass and strength. The mechanism underlying the increase in marrow fat and bone destruction remains elusive. We found that on the way of adipogenic differentiation of marrow stromal cells, receptor activator for NF-κB ligand (Rankl) expression was induced, concomitantly with a down-regulation of osteoprotegerin, which prompted us to hypothesize that cells at a preadipocyte stage express RANKL. This concept was supported by the findings that the early adipogenic transcription factors C/EBPβ and C/EBPδ, but not the late factor peroxisome proliferator-activated receptor γ, bind to the Rankl promoter and stimulate Rankl gene transcription. In fact, when cells isolated from the bone marrow of aging mice were analyzed by flow cytometry, we found that cells expressing the pre-adipocyte marker Pref-1 were RANKL-positive, and the number of these cells was increased with aging, with concomitant down-regulation of osteoprotegerin, and most importantly, that these RANKL+/Pref-1+ marrow cells were capable of generating osteoclasts from bone marrow macrophages. Thus, the capacity of cells at a pre-adipocyte stage to express RANKL via C/EBPβ and C/EBPδ and to support osteoclastogenesis may account partly for the co-progression of fatty marrow and bone destruction with aging.
ABORIGINES AND ALCOHOL INTAKE, EFFECTS AND SOCIAL IMPLICATIONS IN A RURAL COMMUNITY IN WESTERN NEW SOUTH WALES

An examination of the patterns of alcohol drinking in a part‐Aboriginal community in rural New South Wales revealed a prevalence of heavy drinking in 53.2% of men and 3.1% of women. The prevalence of problem drinkers was 31.4% for men and 3.9% for women. However, the chances of becoming a reformed problem drinker appeared greater in Aboriginal than in white people. Drinking was due more to group psychosocial pressures rather than to underlying individual psychiatric disorder. Improvement in social circumstances through aiding these Aborigines in the process of community development showed early promise of reducing both the amount and the frequency of drinking episodes.
All-Optical Analog-to-Digital Conversion Based on Polarization-Differential Interference and Phase Modulation

A novel approach of an all-optical analog-to-digital converter is proposed and demonstrated. One single-phase modulator and a continuous-wave laser diode are used to quantize the sinusoidal tone analog signal. Software sampling measurements yielded an effective number of bits of 4.1. Benefits of the proposed setup are its simple design, high bandwidth, and stability. The scheme is primarily limited in the optical domain by the speed of the phase modulator and in electronic domain by electrical comparators and logic devices
Assessment and Feedback: Examining the Relationship Between Self-assessment and Blind Peer- and Teacher-assessment in TOEFL Writing

This study investigated the nature of self-assessment and blind peerand teacher-assessment in L2 writing. The type of feedback students gave to themselves and peers, the type of feedback used in the revision process, and the source of the feedback used were all analyzed. Additionally, student perceptions of selfand peer-assessment, feedback, and their relationships to perceived writing improvement were also studied. Findings revealed that students in this study did not use teacher feedback significantly more than feedback from themselves or their peers, but they did give different types of feedback than the teacher and favored using feedback related to language use in the revision process. Students perceived their writing abilities to have increased due to selfand peer-assessment but responded more positively to peer-assessment than selfassessment. Surprisingly, students also perceived their abilities to have increased in rubric areas in which the feedback they received was not used and not regarded as useful, and the highest perceived gains in writing ability were in areas which accounted for the lowest amounts of feedback given.
Cultural Competency of GRADUATING BSN NURSING STUDENTS

ABSTRACT Providing culturally appropriate care is an essential nursing competency for new graduates. Multiple curricular approaches are being used to achieve this end. When measured by Campinha‐Bacote's Inventory for Assessing the Process of Cultural Competency Among Healthcare Professionals‐R®, graduating students (n = 515) from six different BSN programs scored, on average, in the culturally aware range. These results suggest that no one curricular approach is proving to be more effective than another in achieving essential cultural competency.