Miracle-dz/UniFAR-FTUs huggingface dataset:
Flexyx Neurotherapy System in the treatment of traumatic brain injury: an initial evaluation.

OBJECTIVE To conduct a preliminary experimental evaluation of the potential efficacy of Flexyx Neurotherapy System (FNS), an innovative electroencephalography (EEG)-based therapy used clinically in the treatment of traumatic brain injury (TBI). PARTICIPANTS Twelve people aged 21 to 53 who had experienced mild to moderately severe closed head injury at least 12 months previously and who reported substantial cognitive difficulties after injury, which interfered with their functioning. DESIGN Participants were randomly assigned to an immediate treatment group or a wait-list control group and received 25 sessions of FNS treatment. They were assessed at pretreatment, posttreatment, and follow-up with standardized neuropsychological and mood measures. RESULTS Comparison of the two groups on outcome measures indicated improvement after treatment for participants' reports of depression, fatigue, and other problematic symptoms, as well as for some measures of cognitive functioning. Most participants experienced meaningful improvement in occupational and social functioning. CONCLUSION On the basis of these results, FNS appears to be a promising new therapy for TBI and merits more extensive evaluation.
2,3-Butanediol Synthesis and the Emergence of the Vibrio cholerae El Tor Biotype

ABSTRACT Vibrio cholerae is an aquatic bacterium that causes the severe diarrheal disease cholera. V. cholerae strains of the O1 serogroup exist as two biotypes, classical and El Tor. Toxigenic strains of the El Tor biotype emerged to cause the seventh pandemic of cholera in 1961 and subsequently displaced strains of the classical biotype both in the environment and as a cause of cholera within a decade. The factors that drove emergence of the El Tor biotype and the displacement of the classical biotype are unknown. Here, we show a unique difference in carbohydrate metabolism between these two biotypes. When grown with added carbohydrates, classical biotype strains generated a sharp decrease in medium pH, resulting in loss of viability. However, growth of El Tor biotype strain N16961 was enhanced due to its ability to produce 2,3-butanediol, a neutral fermentation end product, and suppress the accumulation of organic acids. An N16961 mutant (SSY01) defective in 2,3-butanediol synthesis showed the same defect in growth that classical biotype strains show in media rich in carbohydrates. Importantly, the SSY01 mutant was attenuated in its ability to colonize the intestines of infant mice, suggesting that host carbohydrates may be available to V. cholerae within the intestinal environment. Similarly, the SSY01 mutant failed to develop biofilms when utilizing N-acetyl-d-glucosamine as a carbon source. Because growth on N-acetyl-d-glucosamine likely reflects the ability of a strain to grow on chitin in certain aquatic environments, we conclude that the strains of classical biotype are likely defective compared to those of El Tor in growth in any environmental niche that is rich in chitin and/or other metabolizable carbohydrates. We propose that the ability to metabolize sugars without production of acid by-products might account for the improved evolutionary fitness of the V. cholerae El Tor biotype compared to that of the classical biotype both as a global cause of cholera and as an environmental organism.
ANALISIS PROSES PELAKSANAAN REKRUTMEN, SELEKSI, DAN PENEMPATAN KERJA KARYAWAN (Studi pada Hotel dan Restoran Mahkota Plengkung

Employee is an asset for a company in carrying out its objectives to achieve what is intended, therefore employee is an important resource. The first step that became the main key to obtain good human resource is the recruitment and selection process based on company needs and put someone in appropriate position. Qualified employee can be obtained by doing an appropriate, honest, accurate, and objective way in implementation of the recruitment, selection, and placement process. Otherwise, if these processes are not implemented properly then it will fatal to company achievement.The type of research used to analyze the process of recruitment, selection, and placement of employee at Mahkota Plengkung Hotel and Restaurant to get prospective employee is descriptive research using qualitative approach. Therefore, qualitative research is more precise to be used in order to deepen the analysis of the activities that occur.The results of research on the recruitment, selection, and placement of employee at Mahkota Plengkung Hotel and Restaurant is the hotel has applied all theory and processes as well. There are not many obstacles encountered in the process of recruitment, selection, and placement of employee. Keywords: Recruitment, Selection, Employee Placement АBSTRАK Karyawan merupakan asset bagi perusahaan dalam menjalankan tujuannya agar tercapai apa yang dicita-citakan, untuk itu peranan karyawan adalah suatu sumber daya manusia yang penting. Sejalan dengan itu maka langkah awal yang menjadi kunci utama untuk memperoleh sumber daya manusia yang berkualitas adalah proses rekrutmen dan seleksi guna merekrut tenaga kerja yang sesuai dengan kebutuhan perusahaan, serta penempatan posisi yang sesuai. Pelaksanaan proses rekrutmen, seleksi, dan penempatan karyawan jika dilakukan dengan cara yang tepat, jujur, cermat, dan objektif maka dapat dipastikan perusahaan akan mendapatkan calon karyawan yang berkualitas. Jenis penelitian yang digunakan untuk menganalisis proses pelaksanaan rekrutmen, seleksi, dan penempatan karyawan pada Hotel dan Restoran Mahkota Plengkung adalah penelitian deskriptif dengan menggunakan pendekatan kualitatif, dalam penelitian ini menganalisa tentang bagaimana proses rekrutmen, seleksi, dan penempatan karyawan dalam Hotel dan Restoran Mahkota Plengkung untuk mendapatkan calon karyawannya. Oleh karena itu, peneltian kualitatif lebih tepat digunakan agar lebih mendalam analisa dari kegiatan yang terjadi.Hasil penelitian mengenai proses pelaksanaan rekrutmen, seleksi, dan penempatan karyawan pada Hotel dan Restoran Mahkota Plengkung secara garis besar ketiga proses tersebut sudah diterapkan dengan baik oleh pihak hotel, apa yang ada diteoripun banyak yang diterapkan sehingga tidak banyak kendala yang ditemui dalam proses rekrtumen, seleksi, dan penempatan karyawan. Kаtа Kunci: Rekrutment, Seleksi, Penempatan Kerja
Vaso-obliteration in the canine model of oxygen-induced retinopathy.

PURPOSE To quantify the acute constrictive response of developing retinal blood vessels to hyperoxia and to examine the vaso-obliterative phase of sustained oxygen breathing in the neonatal dog model of retinopathy of prematurity. METHODS Seven littermates were used to examine the acute constrictive response of the developing retinal vessels to hyperoxia (30 minutes to 96 hours of 100% oxygen). ADPase retinal flatmounts were prepared, and morphometric measurements were made using computer-assisted analysis. Vaso-obliteration also was examined in three animals killed after prolonged exposure to hyperoxia (4 days of 100% oxygen) and in three room air controls using ADPase flat-embedded retinas and cross-sections. Choroids were processed for alkaline phosphatase flat-embedding. RESULTS After 1 hour of oxygen breathing, all vascular components showed a reduction in diameter: Arteries were reduced 27%, veins 18.3%, and capillaries 27.7%. Capillary constriction peaked by 24 hours (69.4% reduction), whereas arteries and veins continued to close. Although capillary diameters did not decrease significantly after 24 hours, the number of capillaries, as determined by percent vascular area calculations, continued to decrease in all areas through the additional 3 days of oxygen breathing. In contrast, after 4 days of hyperoxia the choriocapillaris lumenal diameters and percent vascular area did not vary significantly from controls. Analysis of sections taken through various retinal regions of these animals revealed significant decreases (40%) in the volume of the extracellular spaces available for blood vessel formation. Hyperoxia also reduced in a 55.6% decrease in the total number of cells (endothelial cells, ablumenal cells, perivascular cells) within the inner retina; however, there was no significant difference in ganglion cell counts in the two groups. CONCLUSIONS This study demonstrates that the pattern and severity of the reaction of developing retinal vessels to hyperoxia in the newborn dog is similar to that described for the kitten and the premature human. This response is unlike that exhibited by the newborn rat or mouse.
Factor spaces and implications on Kirchhoff equations with clamped boundary conditions

We consider mixed problems for the Kirchhoff elastic and thermoelastic systems, subject to boundary control in the clamped boundary conditions BC (clamped control). If w denotes the elastic displacement and θ the temperature, we establish sharp regularity of {w,wt,wtt} in the elastic case, and of {w,wt,wtt,θ} in the thermoelastic case. Our results complement those by Lagnese and Lions (1988), where sharp (optimal) trace regularity results are obtained for the corresponding boundary homogeneous cases. The passage from the boundary homogeneous cases to the corresponding mixed problems involves a duality argument. However, in the present case of clamped BC, and only in this case, the duality argument in question is both delicate and technical. In this respect, the clamped BC are “exceptional” within the set of canonical BC (hinged, clamped, free BC). Indeed, it produces new phenomena which are accounted for by introducing new, untraditional factor (quotient) spaces. These are critical in describing both interior regularity and exact controllability of mixed elastic and thermoelastic Kirchhoff problems with clamped controls.
Evaluation of autoantibody signatures in meningioma patients using human proteome arrays

Meningiomas are one of the most common tumors of the Central nervous system (CNS). This study aims to identify the autoantibody biomarkers in meningiomas using high-density human proteome arrays (~17,000 full-length recombinant human proteins). Screening of sera from 15 unaffected healthy individuals, 10 individuals with meningioma grade I and 5 with meningioma grade II was performed. This comprehensive proteomics based investigation revealed the dysregulation of 489 and 104 proteins in grades I and II of meningioma, respectively, along with the enrichment of several signalling pathways, which might play a crucial role in the manifestation of the disease. Autoantibody targets like IGHG4, CRYM, EFCAB2, STAT6, HDAC7A and CCNB1 were significantly dysregulated across both the grades. Further, we compared this to the tissue proteome and gene expression profile from GEO database. Previously reported upregulated proteins from meningioma tissue-based proteomics obtained from high-resolution mass spectrometry demonstrated an aggravated autoimmune response, emphasizing the clinical relevance of these targets. Some of these targets like SELENBP1 were tested for their presence in tumor tissue using immunoblotting. In the light of highly invasive diagnostic modalities employed to diagnose CNS tumors like meningioma, these autoantibody markers offer a minimally invasive diagnostic platform which could be pursued further for clinical translation.
Coronary artery bypass grafting in octogenarians: long-term results.

INTRODUCTION As surgical revascularization is becoming more frequent in octogenarians, we reviewed our data to analyze the impact of coronary artery bypass grafting on short- and long-term morbidity and mortality. METHODS We performed a retrospective study of 101 consecutive patients aged 80 years or older, who underwent coronary artery bypass in a single cardiac center between January 2002 and December 2007. The patients were divided into two groups: off-pump (64.4%) and on-pump (35.6%), depending on whether the surgery was performed with cardiopulmonary bypass. Early results and those up to 6 years after surgery were assessed. RESULTS Baseline characteristics were similar between the groups and follow-up was 90% complete. There were no significant differences between groups in mean age (off-pump = 82.7 +/- 18 years vs. on-pump = 82.2 +/- 2.2 years; p = NS) or in logistic EuroSCORE (off-pump = 11.2 +/- 12.3 vs. on-pump = 8.5 +/- 5.1; p = NS). However, the off-pump group had less complete revascularization (off-pump = 43.1% vs. on-pump = 83.3%, p = 0.0001) and shorter mean hospital stay (off-pump = 9.3 +/- 5.4 days vs. on-pump = 11.5 +/- 7.3 days; p = 0.09). Both groups showed low hospital mortality (off-pump = 1.5% vs. on-pump = 2.8%, p = NS). At 6-year follow-up, off-pump surgery patients had the same late prognosis (total survival: off-pump = 80% vs. on-pump = 77.4%, p = NS; cardiovascular mortality: off-pump = 15% vs. on-pump = 16.1%, p = NS). CONCLUSION In octogenarians coronary artery bypass grafting had excellent results. The off-pump technique, even though it can mean less complete revascularization, leads to shorter hospital stay and has the same 6-year results as in patients operated under cardiopulmonary bypass.
The mutual relationship between shift work and depressive complaints--a prospective cohort study.

OBJECTIVE The aim of this study was to examine longitudinally the mutual relationship between shift work and depressive complaints. METHODS Data from the ongoing Maastricht cohort study (1998-2008) were used. Firstly, the impact of shift work on the development of depressive complaints, defined as depressed mood, was studied. Both prospective and retrospective approaches were used, conducting, respectively, survival and logistic regression analyses, correcting for possible confounding factors. Secondly, the impact of depressed mood on changes in shift work at one-year follow-up was studied. All analyses were stratified for men and women and, where possible, for age (<45 versus ≥45 years). RESULTS Overall, the impact of shift work on the development of depressed mood over a ten-year period was rather small, although, male shift workers ≥45 years did contribute to a higher risk of developing depressed mood [hazard risk (HR) 1.37, 95% confidence interval (95% CI) 1.01-1.86]. Retrospective analyses found higher odds of depressed mood and depressive disorder among former or current male shift workers than "never shift workers" [odds ratio (OR) 1.39, 95% CI 1.09-1.79 and OR 1.79, 95% CI 1.32-2.42, respectively]. Results lacked significance when correcting for demographic and work-related factors. Analyses studying the impact of depressed mood on changes in work schedules showed that the risk to change from shift to day work or from shift work to sick leave was higher when depressed mood was reported at baseline [relative risk (RR) shift to day work 1.98, 95% CI 1.13-3.47; RR shift work to sick leave 2.96, 95% CI 2.00-4.29]. CONCLUSIONS Although shift work did not have a large impact on the development of depressed mood, results might be underestimated due to selection processes and possibly overcorrection.
FAKTOR–FAKTOR YANG MEMPENGARUHI KEBIJAKAN DIVIDEN: UKURAN PERUSAHAAN SEBAGAI PEMODERASI

The purpose of this study is to examine the factors affecting dividend policy on non-financial companies. The independent variables consist of return on equity, earnings per share, liquidity, current earnings, growth opportunity, institutional ownership, leverage. As for the moderation variables are firm size. Population of this research are non financials companies listed in Indonesia Stock Exchange from 2012-2015. The samples of this study are 280 data using purposive sampling method. This research uses multiple regression method for data analysis. The results of this study indicate that the current earnings and current earnings, variables that are moderated by the firm size have an influence on the dividend policy. Another independent variables such as return on equity, earnings per share, liquidity, growth opportunity, institutional ownership, leverage, and firm size have no effect on dividend policy.
Analysis of Green Supply Chain Management Implementation on Competitiveness, Environmental Performance, and SMEs Performance

This article analyze the implementation of Green Supply Chain Management (GSCM) on competitiveness, environmental performance and food and beverage SMEs performance in Pasuruan. This study aims to determine how significant GSCM implementation to competitiveness, environmental performance, and SMEs performance. The population was 75 food and beverage SMEs from 13 districts in Pasuruan. Data were collected using questionnaires and interviews. Analysis technique was by Partial Least Square (PLS 1.0). Results indicated that GSCM implementation significantly influenced competitiveness, environmental performance, and SMEs performance. However, there was no significant influence between environmental performance and SMEs performance. Keywords— Food and Beverage SMEs, Green Supply Chain Management; competitiveness; environmental performance; SMEs performance
The neurology clerkship core curriculum

Abstract—Neurologic symptoms are common in all practice settings, and neurologic diseases comprise a large and increasing proportion of health care expenditures and global disease burden. Consequently, the training of all physicians should prepare them to recognize patients who may have neurologic disease, and to take the initial steps in evaluating and managing those patients. We present a core curriculum outlining the clinical neurology skills and knowledge necessary to achieve that degree of preparation. The curriculum emphasizes general principles and a systematic approach to patients with neurologic symptoms and signs. The ability to perform and interpret the neurologic examination is fundamental to that approach, so the curriculum delineates the essential components of the examination in three different clinical settings. The focus of the curriculum is on symptom-based rather than disease-based learning. The only specific diseases selected for inclusion are conditions that are common or require urgent management. This curriculum has been approved by the national organization of neurology clerkship directors and endorsed by the major national professional organizations of neurologists. It is intended as a template for planning a neurology clerkship and as a benchmark for evaluating existing clerkships. It should be especially helpful to clerkship directors, neurology chairs, deans of medical education, and members of external accreditation groups.
A valid comparison of vector and scalar tracking loops

This paper analyzes the benefits offered by vector tracking loops relative to scalar tracking loops. A method for designing equivalent scalar and vector tracking loops is first introduced. The benefits of vector tracking are then determined by comparing the two equivalent algorithms. The improvements in signal tracking afforded by vector tracking are quantified in different scenarios using covariance analysis and Monte Carlo simulations. The vector tracking algorithms show a maximum improvement in tracking threshold of 6.2 dB with an eleven satellite constellation and a minimum improvement of 2.4 dB with a five satellite constellation. The results presented in this paper demonstrate the amount of improvement vector tracking can provide in different situations. Furthermore, the analysis technique used to design the equivalent tracking loops provides a simple way to compare other attributes of the algorithms, such as their multipath immunity and robustness.
Employment protection legislation, labor courts, and effective firing costs

Abstract In many countries, labor courts play a central role in the determination of firing costs by monitoring and supervising the procedures for dismissals, and, eventually, deciding severance payments mandated by the employment protection legislation (EPL). To get some insights about the impact of labor courts on effective firing costs, we explore a new database that contains information on labor courts’ intervention in firings before and after the implementation of significant EPL reforms modifying severance payments and procedures for dismissals. Our results suggest that labor court rulings on economic dismissals did not fully translate the reduction of firing costs mandated by the new EPL to effective firing costs.
ENHANCINGEFFECTOFMIRTAZAPINEON COGNITIVEFUNCTIONSASSOCIATEDWITH PREFRONTALCORTEXINPATIENTSWITH RECURRENTDEPRESSION

Cognitive deficits reflecting disturbance of prefrontal cortex activity have been reported in depressed patients, especially during acute episode (1,4,5,8,19,20). Christopher and MacDonald (6) postulated that depression affects the allocation of attention and all elements of working memory. These abnormalities result in an impairment of performance on neuropsychological tests assessing executive functions such as planning, problem solving and cognitive control. The f-MRI data during the performance of N-back test obtained by Harvey et al (13) indicate that depression may impair cognitive capacity of depressed patients necessitating a recruitment of more brain resources compared to healthy subjects during cognitive task. EREDETIKÖZLEMÉNY
Student perceptions and institutional targets: the matches and mismatches of financial bursary support

Bursary support in Higher Education (HE) helps to enable students from widening participation (WP) backgrounds to more fully engage with their university experiences on an equal basis to their peers. But whilst such support is intended to enhance access to HE, aid retention and increase academic success (which can be monitored using existing institutional data), less is understood about student perceptions of this support. To address this gap, studies are required that investigate both the student experience of receiving financial assistance and, crucially, the mode by which that assistance is delivered: the latter impinging directly on student experience. The survey in this paper used a single UK university in which a range of financial assistance is provided, including bursary funds and hardship funds, and where a significant proportion of students are from WP backgrounds. A mixed methods approach was adopted comprising an online questionnaire, in-depth semi-structured interviews and focus groups. The findings suggest that receiving financial assistance has a positive impact. However, three areas emerged where the administration and impact of financial support could be improved: pre-financial support to better ascertain the nature and level of bursary and any non-financial complementary support required by individual students; embedded financial mentoring to help students with budgeting and addressing any non-financial issues such as stress, academic performance and low confidence; and post-financial guidance to support students towards longer-term financial independence and stability. Improvements in student support could be achieved through strategic amendments to current provision that addresses the three areas noted but, as this study suggests, perhaps more-so by considering the modality of the bursary provision.