Miracle-dz/UniFAR-FTUs huggingface dataset:
A Comparative Study on Social Media Usage and Health Status among Students Studying in Pre-University Colleges of Urban Bengaluru

Introduction: Social Media usage is a “global consumer phenomenon” with an exponential rise within the past few years. The use of social media websites is among the common activity for today's adolescents, they are sometimes overused/misused, which may lead to social media addiction. Objectives: The objective of this study was to assess and compare the prevalence of social media addiction between Government and Private Pre-University (PU) college study subjects, to assess the health problems related to social media usage among the study subjects, and to assess the various factors associated with social media addiction. Materials and Methods: This cross-sectional study was conducted in Government and Private PU colleges situated in a selected ward of urban Bengaluru city through multistage sampling. A total of 1870 study subjects were recruited. A scale was developed to assess social media addiction. Results: The prevalence of social media addiction was 36.9% among users, distributed equally among private and Government PUs. The most common health problem identified was strain on eyes (38.4%), anger (25.5%), and sleep disturbance (26.1%). Being a male, the habit of smoking, alcohol, and tobacco, consumption of junk food, having ringxiety and selfitis were found to be significant risk factors for social media addiction. Conclusion: Social media addiction was found in over one-thirds of subjects and majority had mild addiction.
Pediatric Sports Specialization in Elite Ice Hockey Players

Background: Pediatric sports specialization, defined as intense year-round training in a single sport as a result of excluding other sports for more than 8 months per year, is common in the United States. There are demonstrated physical and social risks to early pediatric sports specialization (defined as before age 12 years). While thought to be needed to acquire appropriate experience and excel in a given sport, there remains little information on when athletes at the highest levels of their sport specialized. This study aimed to define when professional and collegiate ice hockey players specialized. Hypothesis: Early sports specialization before age 12 years will not be common among elite-level (professional and collegiate) ice hockey players. Study Design: Retrospective cross-sectional survey study. Level of Evidence: Level 3. Methods: Male professional and collegiate ice hockey players within 1 National Hockey League organization and 2 National Collegiate Athletic Association (NCAA) organizations who were 18 years of age or older completed a survey at training camp detailing their history of sports participation and specialization. Results: A total of 91 athletes participated in the study (mean age, 22.8 years; range, 18-39 years). The mean age at the start of any sports participation was 4.5 years, and the mean age of sports specialization was 14.3 years. The mean age of specialization in the professional group, the NCAA Division I group, and the NCAA Division III group was 14.1, 14.5, and 14.6 years, respectively. Conclusion: Early pediatric sports specialization is not common in elite-level (professional and collegiate) ice hockey players. Clinical Relevance: Early pediatric sports specialization before age 12 years is not necessary for athletic success in professional and collegiate ice hockey. This study provides further evidence supporting the recommendations of the American Medical Society for Sports Medicine, American Academy of Pediatrics, and American Orthopaedic Society for Sports Medicine against early sports specialization.
Clinicopathological features of immunoglobulin G4‐related pleural lesions and diagnostic utility of pleural effusion cytology

Immunoglobulin (Ig)G4‐related disease is a recently described systemic immune‐mediated fibro‐inflammatory disease that frequently occurs in tumorous form. Herein, we elucidated the clinicopathological and cytological characteristics of IgG4‐related pleural lesions (PLs).
Arthroscopic management of elbow synovial chondromatosis

Objective: We aimed to identify factors that affect pain, complications, and function following elbow arthroscopy for elbow synovial chondromatosis. Methods: We retrospectively reviewed the cases of all patients with elbow synovial chondromatosis treated by arthroscopic synovectomy and loose body removal between January 2000 and January 2016 at our institution. Eleven patients were enrolled (8 male; mean age, 41.7 years). The mean duration of symptoms was 13.7 months, and all patients had a decreased range of motion (ROM) in the affected elbow. By Milgram criteria, there was 1 phase II case, and 10 cases were phase III. Results: All patients were followed postoperatively (mean follow-up, 65 months). The preoperatively restricted ROM of 100° flexion (range, 78°–120°) and extension of 30° (range, 15°–40°) were improved to 130° flexion (range, 120°–140°) and −5° hyperextension (range, −10°–0°). Pain, recorded as the pain subscore of the American Shoulder and Elbow Surgeons questionnaire for elbows, was significantly improved from 32 points (range, 20–50) preoperatively to 85 (range, 70–100) postoperatively (on a scale ranging from 0 [worst pain] to 100 [pain-free]). Recurrence occurred in 2 patients (18.2%) who then received arthroscopic synovectomy and loose body removal again. There were no fractures or neurovascular complications, and no patient developed an infection. Conclusion: Arthroscopic management of synovial chondromatosis of the elbow was an effective and safe therapeutic method. After the intervention, immediate and durable improvement of elbow function can be expected.
Identification of Key Genes and Pathways Associated with RUNX1 Mutations in Acute Myeloid Leukemia Using Bioinformatics Analysis

Background RUNXl plays a key regulatory role in the process of hematopoiesis and is a common target for multiple chromosomal translocations in human acute leukemia. Mutations of RUNX1 gene can lead to acute leukemia and affect the prognosis of AML patients. We aimed to identify pivotal genes and pathways involved in RUNX1-mutated patients of with acute myeloid leukemia (AML) and to explore possible molecular markers for novel therapeutic targets of the disease. Material/Methods The RNA sequencing datasets of 151 cases of AML were obtained from the Cancer Genome Atlas database. Differentially expressed genes (DEGs) were identified using edgeR of the R platform. PPI (protein–protein interaction) network clustering modules were analyzed with ClusterONE, and the KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway enrichment analyses for modules were performed. Results A total of 379 genes were identified as DEGs. The KEGG enrichment analysis of DEGs showed significantly enriched pathways in cancer, extracellular matrix (ECM)-receptor interaction pathway, and cyclic adenosine monophosphate (cAMP) signaling pathway. The top 10 genes ranked by degree were PRKACG, ANKRD7, RNFL7, ROPN11, TEX14, PRMT8, OTOA, CFAP99, NRXN1, and DMRT1, which were identified as hub genes from the protein–protein interaction network (PPI). Statistical analysis revealed that RUNX1-mutated patients with AML had a shorter median survival time (MST) with poor clinical outcome and an increased risk of death when compared with those without RUNX1 mutations. Conclusions DEGs and pathways identified in the present study will help understand the molecular mechanisms underlying RUNX1 mutations in AML and develop effective therapeutic strategies for RUNX1-mutation AML.
An adaptive scale Gaussian filter to explain White’s illusion from the viewpoint of lightness assimilation for a large range of variation in spatial frequency of the grating and aspect ratio of the targets

The variation between the actual and perceived lightness of a stimulus has strong dependency on its background, a phenomena commonly known as lightness induction in the literature of visual neuroscience and psychology. For instance, a gray patch may perceptually appear to be darker in a background while it looks brighter when the background is reversed. In the literature it is further reported that such variation can take place in two possible ways. In case of stimulus like the Simultaneous Brightness Contrast (SBC), the apparent lightness changes in the direction opposite to that of the background lightness, a phenomenon often referred to as lightness contrast, while in the others like neon colour spreading or checkerboard illusion it occurs opposite to that, and known as lightness assimilation. The White’s illusion is a typical one which according to many, does not completely conform to any of these two processes. This paper presents the result of quantification of the perceptual strength of the White’s illusion as a function of the width of the background square grating as well as the length of the gray patch. A linear filter model is further proposed to simulate the possible neurophysiological phenomena responsible for this particular visual experience. The model assumes that for the White’s illusion, where the edges are strong and quite a few, i.e., the spectrum is rich in high frequency components, the inhibitory surround in the classical Difference-of-Gaussians (DoG) filter gets suppressed, and the filter essentially reduces to an adaptive scale Gaussian kernel that brings about lightness assimilation. The linear filter model with a Gaussian kernel is used to simulate the White’s illusion phenomena with wide variation of spatial frequency of the background grating as well as the length of the gray patch. The appropriateness of the model is presented through simulation results, which are highly tuned to the present as well as earlier psychometric results.
ICAM-1 gene rs5498 polymorphism decreases the risk of coronary artery disease

Background: Many studies investigated the association between intercellular adhesion molecule 1 (ICAM-1) gene rs5498 polymorphism and the risk of coronary artery disease (CAD). However, the results were inconsistent. Methods: To clarify convincing association, we conducted a comprehensive meta-analysis by searching in PubMed, Embase, Web of sciences, Sciences citation index, Google scholar, Cochrane Library, and the CNKI databases. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Results: A total of 29 case–control studies with 5,494 cases and 6,364 controls for rs5498 polymorphism were included. The studied populations of this meta-analysis included Caucasians and Asians. Meta-analysis showed that rs5498 polymorphism was associated with the decreased risk of CAD. Stratification analysis of ethnicity found that rs5498 polymorphism decreased the risk of CAD among Caucasians, but not among Asians. Stratification by type of CAD revealed that ICAM-1 gene rs5498 polymorphism was also correlated with the decreased risk of myocardial infarction (MI). Conclusion: In conclusion, this meta-analysis indicates that ICAM-1 gene rs5498 polymorphism decreases the risk of CAD.
High prevalence of echocardiographic abnormalities in older HIV-infected children taking antiretroviral therapy

Background: Antiretroviral therapy (ART) has decreased mortality so that increasing numbers of children with HIV are reaching adolescence. However, longstanding HIV infection and/or its treatment in children is associated with noninfectious complications including cardiac disease. We investigated the prevalence, spectrum and risk factors for echocardiographic abnormalities among children established on ART. Methods: HIV-infected children aged 6–16 years, on ART at least 6 months were enrolled into a cross-sectional study from a public-sector paediatric HIV clinic in Harare, Zimbabwe. A standardized examination including transthoracic echocardiography was performed. Local echocardiographic reference ranges were used to define cardiac abnormalities. Logistic regression was used to examine the association between cardiac abnormalities and risk factors. Results: Of the 201participants recruited, 92 (46%) were girls and median age was 11 (IQR 9–12) years; CD4+ cell count was 727 cells/&mgr;l (IQR 473–935) and 154 (78%) had viral load less than 400 copies/ml. Echocardiographic abnormalities were found in 83 (42%); left ventricular (LV) diastolic dysfunction was the most common abnormality 45 (23%) and LV hypertrophy in 22 (11%). LV and left atrial dilatation were found in 9 (5%) and 16 (8%), respectively. Right ventricular dilatation and systolic dysfunction were found in 13 (7%) and 4 (2%), respectively, of whom 60% had concurrent left heart abnormalities. Current use of nevirapine was associated with LVH [aOR 3.14 (1.13–8.72; P = 0.03)] and hypertension was associated with LV diastolic dysfunction [aOR 3.12 (1.48–6.57; P < 0.01)]. Conclusion: HIV-infected children established on ART have a high burden of echocardiographic abnormalities. Right heart disease was predominantly associated with left heart abnormalities and may be part of a global cardiomyopathic process. Further studies are needed to investigate the natural history, aetiology, and pathogenesis of these abnormalities, so that appropriate monitoring and treatment strategies can be developed.
Kuzuların Gelişimi Üzerine Koyunların Doğum Dönemindeki Vücut Kondisyonu ve Canlı Ağırlığın Etkisi

Bu arastirma, 3-4 yaslarindaki 115 bas Kivircik koyunda, dogum donemindeki vucut kondisyon skoru (VKS) ve canli agirligin kuzularin dogum ve sutten kesim agirligina etkilerini belirlemek icin yurutulmustur. Koyunlarda VKS dogumu takip eden gun icinde, bel bolgesinde omurlarin uzerindeki ve cevresindeki kas ve yag birikiminin palpasyonu ile 1-5 araliginda puanlanarak yapilmistir. Veriler VKS ve canli agirligi iceren bir model ve uretim ozelliklerini etkileyen diger faktorler kullanilarak analiz edilmistir. Dogum donemindeki koyunlarin VKS, canli agirligi, kuzularin dogum agirligi, sutten kesim agirligi ve gunluk canli agirlik artisi (dogumdan sutten kesime kadarki donemde) degerlerinin ortalamasi sirasiyla 2.9, 57.1 kg, 4.5 kg, 23.6 kg ve 0.249 kg olarak saptanmistir. Ele alinan ozelliklerden VKS ile koyunlarin canli agirligi, kuzu dogum agirligi ve gunluk canli agirlik artisi arasinda pozitif onemli korelasyonlar 0.440, 0.301 ve 0.219 bulunmustur (P<0.01; P<0.05). VKS’nin kuzularda sadece dogum agirligi uzerine onemli (P<0.01) bir etkiye sahip oldugu saptanmistir. Sonuc olarak Kivircik koyun surusunde gebelik doneminin sonunda VKS’nin 3.0-3.5 olmasi ve ayni zamanda gebelik boyunca da bu degerin altina dusmemesinin onemi ortaya konmustur.
A solution to Nature's haemoglobin knockout: a plasma-accessible carbonic anhydrase catalyses CO2 excretion in Antarctic icefish gills

ABSTRACT In all vertebrates studied to date, CO2 excretion depends on the enzyme carbonic anhydrase (CA) that catalyses the rapid conversion of HCO3− to CO2 at the gas-exchange organs. The largest pool of CA is present within red blood cells (RBCs) and, in some vertebrates, plasma-accessible CA (paCA) isoforms participate in CO2 excretion. However, teleost fishes typically do not have paCA at the gills and CO2 excretion is reliant entirely on RBC CA – a strategy that is not possible in icefishes. As the result of a natural knockout, Antarctic icefishes (Channichthyidae) are the only known vertebrates that do not express haemoglobin (Hb) as adults, and largely lack RBCs in the circulation (haematocrit <1%). Previous work has indicated the presence of high levels of membrane-bound CA activity in the gills of icefishes, but without determining its cellular orientation. Thus, we hypothesised that icefishes express a membrane-bound CA isoform at the gill that is accessible to the blood plasma. The CA distribution was compared in the gills of two closely related notothenioid species, one with Hb and RBCs (Notothenia rossii) and one without (Champsocephalus gunnari). Molecular, biochemical and immunohistochemical markers indicate high levels of a Ca4 isoform in the gills of the icefish (but not the red-blooded N. rossii), in a plasma-accessible location that is consistent with a role in CO2 excretion. Thus, in the absence of RBC CA, the icefish gill could exclusively provide the catalytic activity necessary for CO2 excretion – a pathway that is unlike that of any other vertebrate. Editors' Choice: Haemoglobin-less Antarctic icefish express a membrane-bound carbonic anhydrase that is plasma accessible and catalyses CO2 excretion at the gills, to compensate for the loss of red blood cells with the enzyme.
The Brain and Inner Ear of the Early Paleocene “Condylarth” Carsioptychus coarctatus: Implications for Early Placental Mammal Neurosensory Biology and Behavior

Mammals underwent a profound diversification after the end‐Cretaceous mass extinction, with placentals rapidly expanding in body size and diversity to fill new niches vacated by dinosaurs. Little is known, however, about the brains and senses of these earliest placentals, and how neurosensory features may have promoted their survival and diversification. We here use computed tomography (CT) to describe the brain, inner ear, sinuses, and endocranial nerves and vessels of Carsioptychus coarctatus, a periptychid “condylarth” that was among the first placentals to blossom during the few million years after the extinction, in the Paleocene. Carsioptychus has a generally primitive brain and inner ear that is similar to the inferred ancestral eutherian/placental condition. Notable “primitive” features include the large, anteriorly expanded, and conjoined olfactory bulbs, proportionally small neocortex, lissencephalic cerebrum, and large hindbrain compared to the cerebrum. An encephalization quotient (EQ) cannot be confidently calculated because of specimen crushing but was likely very small, and comparisons with other extinct placentals reveal that many Paleocene “archaic” mammals had EQ values below the hallmark threshold of modern placentals but within the zone of nonmammalian cynodonts, indicative of small brains and low intelligence. Carsioptychus did, however, have a “conventional” hearing range for a placental, but was not particularly agile, with semicircular canal dimensions similar to modern pigs. This information fleshes out the biology of a keystone Paleocene “archaic” placental, but more comparative work is needed to test hypotheses of how neurosensory evolution was related to the placental radiation. Anat Rec, 302:306–324, 2019. © 2018 Wiley Periodicals, Inc.
Age, but not short-term intensive swimming, affects chondrocyte turnover in zebrafish vertebral cartilage

Both age and intensive exercise are generally considered critical risk factors for osteoarthritis. In this work, we intend to establish zebrafish models to assess the role of these two factors on cartilage homeostasis. We designed a swimming device for zebrafish intensive exercise. The body measurements, bone mineral density (BMD) and the histology of spinal cartilages of 4- and 12-month-old zebrafish, as well the 12-month-old zebrafish before and after a 2-week exercise were compared. Our results indicate that both age and exercise affect the body length and body weight, and the micro-computed tomography reveals that both age and exercise affect the spinal BMD. However, quantitative analysis of immunohistochemistry and histochemistry indicate that short-term intensive exercise does not affect the extracellular matrix (ECM) of spinal cartilage. On the other hand, the cartilage ECM significantly grew from 4 to 12 months of age with an increase in total chondrocytes. dUTP nick end labeling staining shows that the percentages of apoptotic cells significantly increase as the zebrafish grows, whereas the BrdU labeling shows that proliferative cells dramatically decrease from 4 to 12 months of age. A 30-day chase of BrdU labeling shows some retention of labeling in cells in 4-month-old spinal cartilage but not in cartilage from 12-month-old zebrafish. Taken together, our results suggest that zebrafish chondrocytes are actively turned over, and indicate that aging is a critical factor that alters cartilage homeostasis. Zebrafish vertebral cartilage may serve as a good model to study the maturation and homeostasis of articular cartilage.
Intracanal heating of sodium hypochlorite: Scanning electron microscope evaluation of root canal walls

Introduction: The aim of this study is to evaluate the surface of root canals dentine using scanning electron microscope (SEM) after instrumentation with rotary Nickel-Titanium systems and two different protocols of activation of sodium hypochlorite (NaOCl) (extracanal heating at 50°C and intracanal heating at 180°C), to assess the presence/absence of smear layer and also the presence/absence of open dentinal tubules along the walls at the coronal, middle, and apical third of each sample. Materials and Methods: Thirty-six single-rooted teeth were selected, divided into three groups and shaped with ProTaper Universal instruments following irrigation protocols with 5.25% NaOCl. At the end of the preparation, three different protocols of activation were used: nonheated NaOCl in Group A, extra-canal heated NaOCl at 50°C for Group B and intracanal heated NaOCl at 180°C for Group C. Specimens were cut longitudinally and analyzed by SEM at standard magnification of ×1000. The presence/absence of the smear layer as well as the presence/absence of open tubules at the coronal, middle, and apical third of each canal were estimated using a five-step scale for scores. Numeric data were analyzed using Kruskal–Wallis and Mann–Whitney U statistical tests and significance was predetermined at P < 0.05. Results: Kruskal–Wallis analysis of variance (ANOVA) for debris score showed significant differences among the Ni-Ti systems (P < 0.05). Mann–Whitney test confirmed that Group A presented significantly higher score values than other Ni-Ti systems. The same results were assessed considering the smear layer scores. ANOVA confirmed that the apical third of the canal maintained a higher quantity of debris and smear layer after preparation of all the samples. Discussion and Conclusions: Intra-canal heating of NaOCl at 180°C proved to be more effective in obtaining clean canal walls. On the other hand, extra-canal heating at 50°C of NaOCl left a higher quantity of debris and the smear layer was widely represented.
Three new species of Krogia (Ramalinaceae, lichenised Ascomycota) from the Paleotropics

Abstract Krogiaborneensis Kistenich & Timdal, K.isidiata Kistenich & Timdal and K.macrophylla Kistenich & Timdal are described as new species, the first from Borneo and the two latter from New Caledonia. The new species are supported by morphology, secondary chemistry and DNA sequence data. Krogiaborneensis and K.isidiata contain sekikaic and homosekikaic acid, both compounds reported here for the first time from the genus. Krogiamacrophylla contains an unknown compound apparently related to boninic acid as the major compound. DNA sequences (mtSSU and nrITS) are provided for the first time for Krogia and a phylogeny of the genus based on 15 accessions of five of the six accepted species is presented. Krogiaantillarum is reported as new to Brazil, Guatemala and Mexico.