Miracle-dz/UniFAR-FTUs huggingface dataset:
Shell osteochondral allografts of the knee: comparison of mr imaging findings and immunologic responses.

PURPOSE To define the magnetic resonance (MR) imaging appearance of shell osteochondral allografts of the knee and compare the MR findings with antibody responses. MATERIALS AND METHODS Thirty-six grafts were evaluated with a 1.5-T unit with T1-, intermediate-, and T2-weighted, and three-dimensional spoiled gradient-recalled MR imaging at 3, 6, 12, 24, and/or 36 months after surgery. Nineteen patients underwent imaging serially. Two osteoradiologists scored by consensus host marrow edema, thickness of graft-host interface, signal intensity of graft marrow, cyst formation, joint effusion, articular cartilage defects, and surface collapse. Patients were divided into antibody-positive (AP) (n = 11) and antibody-negative (AN) (n = 25) groups evenly distributed across the different time points on the basis of results of anti-human leukocyte antigen antibody screening. MR findings for the two groups were compared. RESULTS AP patients demonstrated greater mean edema (P<.002), thicker interface (P<.03), and more abnormal graft marrow (P<.04) than AN patients, and they had a higher proportion of surface collapse (P<.03). CONCLUSION Humoral immune responses were associated with more inflammation and less complete incorporation after allograft placement. MR imaging shows promise as a surrogate biomarker for success of shell osteochondral allograft implantation.
Adding the entrepreneurial orientation among the theoretical perspectives to analyse the development of research-based spin-offs

To date, research-based spin-offs (RBSOs) have been studied from an institutional perspective, from an entrepreneurial orientation (EO) or from a resource-based view. Although scholars have expressed an interest in studying RBSOs, nobody has incorporated the three different perspectives into a single integrated model. Therefore, the present article aims to develop a holistic theoretical framework, studying the human, financial, technological and social resources of an RBSO and highlighting whether the EO influences an RBSO during its generation and development phases. A case study from the information and communication technology sector was selected, and data were collected through a structured questionnaire complemented with in-depth and on-site interviews. The holistic framework adopted allowed to highlight the peculiarities of the RBSO: the marked vocation for scientific research, the EO of the founding team and the important role of the parent organization, mostly in supplying intangible assets. The emerged evidence shows how it is possible to generate and develop a successful RBSO, providing useful insights from both academic and managerial viewpoints.
The Use of the Eurosystem's Monetary Policy Instruments and Operational Framework since 2009

This paper provides a comprehensive overview of the use of the Eurosystem's monetary policy instruments and the operational framework from the third quarter of 2012 until the first quarter of 2016. The paper reviews the context of Eurosystem market operations, counterparty and collateral framework, participation in tender operations, recourse to standing facilities, patterns of reserve fulfilment, outright asset purchase programmes, as well as the impact of the ECB’s monetary policy implementation on the Eurosystem's balance sheet and liquidity conditions. JEL Classification: D02, E43, E58, E65, G01
Subsidy Incidence in Privately Negotiated Spot Markets: Experimental Evidence

Abstract We use experimental methods to investigate subsidy incidence, the transfer of subsidy payments from intended recipients to other economic agents, in privately negotiated spot markets. Our results show that market outcomes in treatments with a subsidy given to either buyers or sellers are significantly different from both a no-subsidy treatment and the competitive prediction of a 50% subsidy incidence. The disparity in incidence across treatments relative to predicted levels suggests that incidence equivalence does not hold in this market setting. Moreover, we find no statistical difference in market outcomes when benefits are framed as a “subsidy” versus a schedule shift.
A 52-kb deletion in the SOST-MEOX1 intergenic region on 17q12-q21 is associated with van Buchem disease in the Dutch population.

Van Buchem disease is an autosomal recessive sclerosing bone dysplasia characterized by skeletal hyperostosis, overgrowth of the mandible, and a liability to entrapment of the seventh and eighth cranial nerves. The genetic determinant maps to chromosome 17q12-q21. We refined the critical interval to the < 1-Mb region between D17S2250 and D17S2253 in 15 affected individuals, all of whom shared a common disease haplotype. Furthermore, we report here the identification of a 52-kb deletion located within the interval and encompassing D17S1789 that is 100% concordant with the disorder. Although the deletion itself does not appear to disrupt the coding region of any known or novel gene(s), the closest flanking genes are MEOX1 on the proximal side, and SOST on the distal side of the deletion. MEOX1 is known to be important for the development of the axial skeleton, whereas the SOST gene is the determinant of sclerosteosis, a disorder that shares many features with van Buchem disease, thus raising the possibility that van Buchem disease results from dysregulation of the expression of one or both of these genes.
[Treatment of residual obstetrical brachial plexus palsy with tendon transfer].

OBJECTIVES We evaluated the results of the correction of adduction and internal rotation deformities of the shoulder associated with residual obstetrical brachial plexus palsy (OBPP) by the transfer of latissimus dorsi and teres major muscles to the rotator cuff. METHODS In order to correct adduction and internal rotation deformities associated with residual OBPP, 10 patients (7 males, 3 females; mean age 8.1 years; range 4 to 19 years) underwent transfer of the latissimus dorsi and teres major muscles to the rotator cuff and lengthening of the pectoralis major tendon with Z-plasty. The right and left extremities were affected in seven and three patients, respectively. Involvement of the C5-C6 nerve roots was detected in four, and C5-C6-C7 nerve roots in six patients. In two patients with a positive Putti sign, axillary roentgenograms showed posterior subluxation of the humeral head, and magnetic resonance and computed tomography scans revealed type III glenohumeral deformity. Functional evaluations were made using a 5-point scoring system proposed by Mallet. The mean follow-up was 23.6 months (range 5 to 42 months). RESULTS Postoperatively, the mean abduction and external rotation were 134.5 degrees (range 95 degrees to 170 degrees ) and 70 degrees (range 45 degrees to 90 degrees ), respectively. The mean global abduction score was 4, external rotation score was 4.2, and the scores assigned to the ability to move hand to the neck and mouth were 3.5. Of two patients with type III glenohumeral deformity, whose ages were four and 19 years, abduction and external rotation were 150 degrees and 45 degrees in the former, 135 degrees and 70 degrees in the latter, respectively. CONCLUSION The transfer of the latissimus dorsi and teres major tendons is a necessary procedure to restore external rotation and abduction functions of paralysed shoulders. Compared to other techniques employed, it offers obvious advantages in terms of ease and cost, as well.
A randomized controlled trial of a money management-based substance use intervention.

OBJECTIVE Money management has been implemented, often in bundled interventions, as a strategy to counteract spending of public support checks and other funds on drugs and alcohol. The authors conducted a randomized controlled trial of a voluntary money management program as an adjunctive treatment for patients in treatment for mental illness, substance use disorders, or both. In the advisor-teller money manager (ATM) intervention, a money manager stores patients' checkbooks and automated bank cards, trains patients to manage their own funds, and links spending to activities related to their treatment goals. METHODS Eighty-five veterans with recent use of alcohol or cocaine were randomly assigned to 36 weeks of the ATM intervention or a control intervention (completion of a simple financial workbook). RESULTS With ATM, 75% of veterans gave their checkbook to their money manager to hold, and participants attended significantly more therapy sessions than those assigned to the control therapy (mean of 20.6 versus 8.1 sessions). Although participants assigned to ATM did not show significantly greater improvement over time on the primary outcomes (self-reported abstinence from alcohol and cocaine and negative urine tests for cocaine metabolite), they reduced their Addiction Severity Index drug and alcohol use composite scale scores more rapidly than the control group. High rates of abstinence in both groups created a ceiling effect, limiting the power to detect improved abstinence rates. CONCLUSIONS In this relatively small trial, ATM, a money management intervention, showed promise in engaging patients, improving their money management, and improving some substance abuse outcomes.
Percutaneous Injection of Radiopaque Gelified Ethanol for the Treatment of Lumbar and Cervical Intervertebral Disk Herniations: Experience and Clinical Outcome in 80 Patients

Eighty lumbar and 9 cervical spine herniations were treated with percutaneous intradiskal injection of gelified ethanol under fluoroscopy with 36 injections made simultaneously for 2 disk herniations. Post treatment symptom improvement was reported by 85% of patients with lumbarand 83% of those with cervical disk herniations. BACKGROUND AND PURPOSE: Chemonucleolysis represents a minimally invasive percutaneous technique characterized by an intradiskal injection of materials under fluoroscopic or CT guidance. Recently, a substance based on radiopaque gelified ethanol has been introduced. The purpose of this study was to describe the indications, procedure, safety, and efficacy of radiopaque gelified ethanol in the percutaneous treatment of cervical and lumbar disk herniations. MATERIALS AND METHODS: Between September 2010 and August 2013, 80 patients (32 women and 48 men; age range, 18–75 years) were treated for 107 lumbar disk herniations (L2–L3, n = 1; L3–L4, n = 15; L4–L5, n = 53; and L5–S1, n = 38) and 9 cervical disk herniations (C4–C5, n = 2; C5–C6, n = 2; C6–C7, n = 3; and C7–D1, n = 2) by percutaneous intradiskal injection of radiopaque gelified ethanol under fluoroscopic guidance. Thirty-six patients underwent a simultaneous treatment of 2 disk herniations. Patient symptoms were resistant to conservative therapy, with little or no pain relief after 4–6 weeks of physical therapy and drugs. All patients were evaluated by the Visual Analog Scale and the Oswestry Disability Index. RESULTS: Sixty-two of 73 (85%) patients with lumbar disk herniations and 6/7 (83%) patients with cervical disk herniations obtained significant symptom improvement, with a Visual Analog Scale reduction of at least 4 points and an Oswestry Disability Index reduction of at least 40%. Leakage of radiopaque gelified ethanol in the surrounding tissues occurred in 19 patients, however without any clinical side effects. CONCLUSIONS: In our experience, percutaneous intradiskal injection of radiopaque gelified ethanol is safe and effective in reducing the period of recovery from disabling symptoms.
Neuromuscular electrical stimulation training increases intermuscular fascial length but not tendon cross-sectional area after spinal cord injury.

OBJECTIVE To determine the effects of 12 weeks of neuromuscular electrical stimulation (NMES) training with ankle weights on intermuscular fascial length and patellar tendon cross-sectional area (CSA) in persons with spinal cord injury (SCI). METHODS This study was a pre-post intervention. Seven men with motor complete SCI were randomly assigned to a resistance training plus diet (RT + diet) group (n = 4) or a diet control group (n = 3). Participants in the RT + diet group were enrolled in a 12-week leg extension weight-lifting program via surface NMES of the knee extensor muscle group. The length of mid-thigh intermuscular fascia and the patellar tendon CSA were measured using MRI. RESULTS In the RT + diet group, a nonsignificant 8% increase in the CSA of the patellar tendon (P = .14) was noted. The length of the mid-thigh intermuscular fascia increased by 19% and 23% in the right (P = .029) and left (P = .015) legs, respectively, with no changes in the diet control group. Positive relationships were noted between skeletal muscle CSAs of the whole thigh (r = 0.77, P = .041) and knee extensors (r = 0.76, P = .048) and intermuscular fascial length. CONCLUSION The preliminary results suggest that noncontractile connective tissue structures of the knee extensors respond differently to NMES training after SCI. Skeletal muscle hypertrophy is associated with an increase in the intermuscular fascial length.
Evaluation of the operational condition and reliability of surge arresters used on medium voltage networks

Laboratory studies were conducted on gapped silicon-carbide arresters and gapless metal-oxide surge arresters (MOAs) gathered from 24 kV networks in Finland. A total of 410 arresters of 21 different types from eight different manufacturers were investigated. A total of 246 silicon-carbide arresters (age from 14 to 38 years) and 164 MOAs (age from 4 to 15 years) were studied at the High Voltage Laboratory of Tampere University of Technology. The results of the measurements on MOAs were compared to the measurements conducted earlier on 16 new, unused MOAs of the same types as those taken from the field. A portion of 16.7% (41 specimens) of the silicon-carbide arresters failed in the ac voltage withstand test and 34.5% (85 specimens) did not pass the lightning impulse sparkover test. The current impulse test of the silicon-carbide arresters resulted in a lot of damage. Due to the damage and failures in the electrical tests the authors recommend the electricity companies in Finland to exchange 7 types of silicon-carbide arresters to new MOA types in order to reduce the risk of arrester failures and to improve the protection levels in MV networks. All the ten MOA types studied were generally in good condition after being used 4-15 years in networks. Only three specimens (out of 164) could be evaluated to be faulty. Comparisons between the MOAs gathered from the networks and the unused MOAs showed that the protection levels of the MOA types studied had remained stable and the ac durability of these MOA types had not remarkably weakened during the use in networks.
Cutaneous factors related to the risk of malignant melanoma

In a case‐control study, 287 women with malignant melanoma were compared with 574 age‐matched controls. Red hair colour at age 5 years was associated with a tripling of risk [relative risk (RR) = 3.0], blonde hair with a 60% increase (RR=1.6) and fair skin with a doubling (RR = 2.1). Women with melanoma also reported that they tended to burn (RR = 1.4) and to freckle (RR =1.9) after exposure to sunlight. Since fair skin, red hair, and the tendency to burn or freckle after exposure to sunlight all cluster in the same individuals, the extent to which each of these factors had an independent influence on susceptibility to melanoma was investigated. Hair colour, especially red hair, proved to be the major determinant, followed by skin colour.
Estimation of UHF RFID Reading Regions in Real Environments

The reading range is one of the most critical performance indicators of radio-frequency identification (RFID) systems. It depends on many physical and geometrical parameters. Typically, in the ultra-high-frequency band (UHF: 860 MHz to 960 MHz), the maximum size of the reading region is estimated by the free-space propagation model. This is based on the Friis formula, even if much more accurate predictions may be accomplished nowadays by time-consuming electromagnetic simulations, accounting for the antennas and the interaction with the nearby environment. This paper proposes a general parameterization of the three-dimensional reading region. This done having introduced all of the accessible system data, such as the emitted power, the reader and tag-over-object radiation patterns, and also the interrogation duty cycle, the scenario features, and the safety regulation constraints. Within this framework, the opportunity and some improvements of the free-space model are analyzed. They are compared with measurements and with more-accurate three-dimensional simulations of realistic environments. The discussion demonstrates the validity range of the free-space approximations, and evaluates the improvement achieved by including the main interactions with the environment. The derived formulas are ready to use and to be applied for the planning and optimization of reader-tag networks.
Prevalence of pulmonary hypertension in sickle cell anaemia patients of a tertiary hospital in Nigeria

Background: Sickle cell disease (SCD) is an inherited haemoglobinopathy characterised by recurrent organ hypoxia-reperfusion cycles which may result in repeated organ damage including the lungs and heart. In SCD, pulmonary hypertension is a known complication that may precede or complicate acute chest syndrome which is often fatal. This study seeks to know the prevalence of pulmonary hypertension and its relationship with clinical and laboratory parameters in sickle cell disease patients attending a tertiary hospital in Lagos. Materials and Methods: This was a case — control study involving patients with sickle cell disease recruited from adult sickle cell clinic of Lagos State University Teaching Hospital, Ikeja and HbAA controls matched for age and sex from a tertiary educational institution in Lagos. Both the patients and controls were subjected to echocardiography and pulmonary hypertension was deduced from their cardiac tricuspid regurgitant jet velocity. Other parameters measured were age, body mass index, full blood count, red cell indices, foetal haemoglobin, chest X-ray, liver function tests, lactate dehydrogenase and pulmonary function tests. Consenting patients were 56 HbSS in steady state and 28 HbAA controls matched for age and sex. Data was analysed using SPSS version 16.0. Results: The mean age of patients was 22 ± 6 years. In two 2 of 56 (3.6%) of the participants with sickle cell disease, the pulmonary artery pressure was > 25mmHg and there was significant difference in the mean of the pulmonary artery pressure of the control and that of the patients (P-value 0.013). Also, using the appropriate correlation tests, there was significant relationship between the pulmonary artery pressure and lactate dehydrogenase, aspartate transferase and haematocrit in patients with sickle cell disease. Conclusion: Sickle cell disease is an independent cause of pulmonary artery hypertension. Variation in cardiovascular reactions to recurrent hyperhaemolysis and hyperdynamic state in sickle cell disease may explain differences in the development of cardiac complications. Exploration of these reactions may reveal other therapeutic measures to prevent complications in sickle cell disease. Clinical assessment of adult patients with sickle cell disease should include echocardiography.
Long‐Term Follow‐Up after Finger and Upper‐Limb Replantation: Clinical, Angiologic, and Lymphographic Studies

This 10-year follow-up study evaluates 25 patients with a total of 57 successfully replanted fingers and six successfully replanted upper limbs. The global functional loss, including loss of range of motion, sensibility, and strength of the hand, was determined using the "Millesi score. " The hemodynamic parameters of replanted and control fingers under resting and stress conditions were measured using a laser Doppler flowmeter. The lymphatic system at the site of replantation was examined by fluorescence microlymphography. All patients showed a considerable functional loss, according to the Millesi score, that averaged 56 percent of the normal function of the hand. In order to overcome functional deficit, many patients had developed successful compensatory mechanisms. In general, the patients themselves subjectively rated their functional deficits lower than indicated by the Millesi score. Laser Doppler flowmetry at rest and after arterial occlusion, and capillaroscopy before, during, and after a cold provocation test, revealed subnormal resting flow conditions and significantly decreased vascular capacity in the replanted fingers. Lymphatic drainage capacity was also significantly reduced despite documented reanastomosis between the skin microlymphatic network distal and proximal to the scar (fluorescence microlymphography). The coexistence of functional loss with compensatory mechanisms, decreased reactive hyperemia, and deficit in lymphatic drainage, present in all patients, must be considered as definitive sequelae of the initial injury.
Effects of Echinacea extracts on macrophage antiviral activities

Type I interferons are a class of cytokines synthesized by leukocytes such as macrophages that limit viral replication. We hypothesized that one mechanism whereby Echinacea spp. extracts may enhance immunity is through modulating interferon‐associated macrophage pathways. We used herpes simplex viral infection in the murine macrophage cell line RAW264.7 and monitored virus‐induced cell death, interferon secretion, and two intracellular proteins that indicate activation of interferon pathways. Cells were incubated with control media or extracts from four different species (E. angustifolia, E. purpurea, E. tennesseensis, E. pallida). Cells incubated with extracts prior to infection showed very modest enhancement of viability, and no increase in the secretion of interferons α or β as compared to control cells. Virus‐infected macrophages treated with extracts from E. purpurea showed a small (<2‐fold) induction of guanylate binding protein (GBP) production, but no effect of extracts from other species was observed. In virus‐infected cells, all the extracts increased the amount of inducible nitric oxide synthase (iNOS) protein, and this effect varied by type of extraction preparation. Together, these results suggest that any potential antiviral activities of Echinacea spp. extracts are likely not mediated through large inductions of Type I interferon, but may involve iNOS. Copyright © 2009 John Wiley & Sons, Ltd.