Miracle-dz/UniFAR-FTUs huggingface dataset:
Intraperitoneal Hyperthermic Perfusion Combined with Surgery Effective for Gastric Cancer Patients with Peritoneal Seeding

Fifteen patients with far-advanced gastric cancer were given surgical treatment followed by intraperitoneal hyperthermic perfusion (IPHP) with mitomycin C (MMC) and misonidazole (MIS), a thermosensitizing drug. Immediately after extensive resection of the abdominal tumors, a 2-hour IPHP was performed at the inflow temperature of 44.7 to 48.7 C, using equipment designed for treatment of cancerous peritoneal seeding as a closed circuit, and under hypothermie general anesthesia at 30 to 31 C. In nine of the 15 patients with peritoneal seeding and/or ascites, cancerous ascites was absent after this treatment. In all cases, repeated cytologie examinations of the lavage from Douglas's pouch were negative. The postoperative courses were uneventful except for Patients 1 and 10, in whom slight leakage occurred. All patients were discharged and are in good health at the time of this writing, 7.2 ± 4.6 months after the treatment. The Case 4 Patient recently died in a traffic accident. In all patients, transient hepatic dysfunction and hypoproteinemia occurred after the operation. This extensive surgery combined with IPHP using MMC and MIS was well tolerated and is a safe antitumor treatment for gastric cancer with peritoneal dissemination. Neurotoxicity due to MIS was nil.
GASIFICATION-BASED BIOREFINERY FOR MECHANICAL PULP MILLS

The modern concept of "biorefinery" is dominantly based on chemical pulp mills to create more value than cellulose pulp fibres, and energy from the dissolved lignins and hemicelluloses. This concept is characterized by the conversion of biomass into various biobased products. It includes thermochemical processes such as gasification and fast pyrolysis. In mechanical pulp mills, the feedstock available to the gasification-based biorefinery is significant, including logging residues, bark, fibre material rejects, biosludges and other available fuels such as peat, recycled wood, and paper products. This work is to study coproduction of bio-automotive fuels, biopower, and steam via gasification in the context of the mechanical pulp industry. Biomass gasification with steam in a dual-fluidized bed gasifier (DFBG) was simulated with ASPEN Plus. From the model, the yield and composition of the syngas and the contents of tar and char can be calculated. The model has been evaluated against the experimental results measured on a 150 KWth Mid Sweden University (MIUN) DFBG. The model predicts that the content of char transferred from the gasifier to the combustor decreases from 22.5 wt. % of the dry and ash-free biomass at gasification temperature 750 °C to 11.5 wt. % at 950 °C, but is insensitive to the mass ratio of steam to biomass (S/B). The H2 concentration is higher than that of CO under normal DFBG operating conditions, but they will change positions when the gasification temperature is too high above about 950 °C, or the S/B ratio is too far below about 0.15. The biomass moisture content is a key parameter for a DFBG to be operated and maintained at a high gasification temperature. The model suggests that it is difficult to keep the gasification temperature above 850 °C when the biomass moisture content is higher than 15.0 wt. %. Thus, a certain amount of biomass needs to be added in the combustor to provide sufficient heat
On the role of population size and niche radius in fitness sharing

We propose a characterization of the dynamic behavior of an evolutionary algorithm (EA) with fitness sharing as a function of both the niche radius and the population size. Such a characterization, given in terms of the mean and the standard deviation of the number of niches found during the evolution, can be applied to any EA employing a proportional selection mechanism and does not make any assumption on either the fitness landscape or the internal parameters of the EA itself. On the basis of the proposed characterization, a method for estimating the optimal values for the population size and the niche radius without any a priori information on the fitness landscape is presented and tested on a standard set of functions. The proposed method also provides the best solution for the problem at hand, i.e., the solution obtained in correspondence of such optimal values, at no additional cost.
Obsessional symptoms and obsessional personality traits in patients with depressive illnesses

SUMMARY An inventory of obsessional symptoms and traits was administered to patients with depressive illnesses while they were ill and again after recovery. They obtained higher scores than normals even when well and their scores increased considerably during episodes of depression in proportion to the depth of the depression. In mania, on the other hand, obsessional symptoms are rare.
Envejecimiento poblacional y magnitud de la dependencia en Argentina y México: perspectiva comparada con España

El objetivo del trabajo es analizar los procesos de envejecimiento poblacional y la magnitud de la poblacion mayor en situacion de dependencia en la actualidad en Mexico y en Argentina, desde una perspectiva comparada con Espana. Se construyeron series historicas de la proporcion de personas de 65 anos y mas sobre la base de los censos de poblacion de cada pais. La cantidad de personas en situacion de dependencia y la prevalencia de dicha condicion se aproxima a partir de encuestas de discapacidad o envejecimiento para Argentina, Espana y Mexico, utilizando indicadores de actividades basicas e instrumentales de la vida diaria. Los resultados indican que tanto Argentina como Mexico presentan una prevalencia de dependencia superior a la observada en Espana, lo cual, sumado al rapido crecimiento en la poblacion de adultos mayores en la region, pone de relieve la necesidad de avanzar en el diseno de politicas de prevencion y cuidados de largo plazo en estos paises.
Characterization and distribution of Pasteurella species recovered from infected humans

During a 3-year period, all Pasteurella strains recovered at the Clinical Microbiological Laboratory, Lund, Sweden, were studied biochemically with respect to their relationship to the recently described taxa of this genus. Of 159 strains recovered from 146 infected humans, 95 were identified as Pasteurella multocida subsp. multocida, 21 as Pasteurella multocida subsp. septica, 28 as Pasteurella canis, 10 as Pasteurella stomatis, and 5 as Pasteurella dagmatis. The homology within and between the Pasteurella species regarding cellular fatty acids and enzymatic activities was also studied. Strains of the different Pasteurella species were indistinguishable from each other regarding fatty acid composition; all strains contained major amounts of C14:0, C16:1, C16:0, and 3-OH-C14:0 acids and minor amounts of C18:2, C18:1, and C18:0 acids. Neither did the enzymatic activities distinguish between strains belonging to different species. In addition, of 56 strains examined, toxin production was demonstrated only in 1 strain each of P. multocida subsp. multocida and P. canis. Except for one severe case of necrotizing cellulitis involving P. dagmatis, P. multocida subsp. multocida or P. multocida subsp. septica was recovered in the more serious cases of infection. Except for P. canis, which in all cases was associated with dog bites, most Pasteurella strains were recovered in cases of infection associated with cat bites or scratches. Pasteurella strains occurred in four infected patients without evident connections with animals.
Correlation of acute cocaine-induced changes in local cerebral blood flow with subjective effects.

The authors administered 48 mg of intravenous cocaine or placebo to eight abstinent cocaine users in a double-blind, crossover design and examined blood flow using single photon emission computed tomography. Cocaine produced significant decreases in frontal cortical and basal ganglia blood flow; these latter correlated negatively with increases in self-ratings of "rush" and "high. " The authors conclude that these local effects are compatible with dopaminergic system involvement.
Wound healing ability of Xenopus laevis embryos. I. Rapid wound closure achieved by bisectional half embryos

We examined wound closure in ‘half embryos’ produced by the transverse bisection of Xenopus laevis embryos at the primary eye vesicle stage. Both the anterior‐ and posterior‐half embryos survived for more than 6 days, and grew into ‘half tadpoles’. Histology and videomicroscopy revealed that the open wound in the half embryo was rapidly closed by an epithelial sheet movement in the wound marginal zone. The time‐course of wound closure showed a downward convex curve: the wound area decreased to one‐fifth of the original area within 30 min, and the wound continued to contract slowly thereafter. The rapidity of closure of the epidermis as well as the absence of inflammatory cells are typical features of an embryonic type of wound healing. There was a dorso‐ventral polarity in the motility of the epidermis: the wound was predominantly closed by the ventral and lateral epidermis. The change in the contour of the wound edge with time suggested a complex mechanism involved in the wound closure that could not be explained only by the purse‐string theory. The present experimental system would be a unique and useful model for analyses of cellular movements in the embryonic epithelia.
Creating an agreed discharge: discharge planning for clients with high care needs.

AIMS The purpose of this study was to develop a conceptual model of discharge planning by discharge planning nurses for clients returning home with high care needs. BACKGROUND In Japan, discharge planning plays an important role in the smooth and timely discharge of clients from medical facilities. Discharge planning nurses often oversee such processes, especially for clients with high care needs. However, a conceptual model that guides discharge planning nurses during the discharge planning process is currently lacking. DESIGN Qualitative. METHODS A constant comparative approach was used to collect and analyse data from semi-structured interviews conducted with 13 discharge planning nurses working at medical centres throughout Japan. Each discharge planning nurse described her discharge planning activities for a client with high care needs. RESULTS 'Creating an agreed discharge' was a core category of the discharge planning process carried out by discharge planning nurses. The process consisted of: (1) developing a blueprint, (2) reaching an agreement, (3) materialising the agreed plan and (4) sending the client home. The discharge planning nurse starts by developing a blueprint of client/family life after discharge. The blueprint guides each discharge planning nurse thereafter throughout their various activities. She or he also strives to reach an agreement with the client/family regarding the discharge plan. Discharge planning nurse activities detailed here are based on the client/family's daily life, and adjustments to the plan are made within an agreeable range. CONCLUSIONS Developing a blueprint, revising and refining it to establish an agreed discharge plan based on the client/family's situations and preferences and coming to an agreement for further revisions and the final plan were essential in the discharge planning process. A precise projection of the client's condition, community resource knowledge, estimating family care and understanding specific client/family thoughts on returning home were vital to a successful discharge planning process. RELEVANCE TO CLINICAL PRACTICE These findings may be useful for the development of discharge planning guidelines.
Bank Capital , Survival , and Performance around Financial Crises

What does capital do for banks around financial crises? We address this question by examining the effect of pre-crisis bank capital ratios on banks’ ability to survive financial crises, and on their competitive positions, profitability, and stock returns during and after such crises. We distinguish between two banking crises and three market crises that occurred in the U.S. over the past quarter century, and examine small, medium, and large banks separately. The evidence suggests that capital helps small banks to survive banking and market crises, and helps medium and large banks to survive banking crises. Moreover, the manner in which a bank exits when it does not survive a crisis (e.g., because it is acquired with or without government assistance) also depends on its pre-crisis capital ratio. Higher capital enables banks of all size classes to improve their market shares during banking crises and these banks are generally able to maintain their improved shares afterwards. Around market crises, higher capital enables only small banks to improve their market shares. Similar, but weaker results are obtained based on profitability. Higher capital also led to higher abnormal stock returns for banks during one of the banking crises. During “normal” times between crises, most of the relative benefits of higher capital are experienced only by small banks. Overall, our results suggest that the importance of bank capital is elevated during crises, and particularly banking crises.
Interretinal transduction of injury signals after unilateral optic nerve crush

In this study, we report that partial unilateral optic nerve crush in the rat affects the number of retinal ganglion cells of the contralateral eye still in continuity with the ipsilateral superior colliculus. The reduction in cell number of the uncrossed retinal projection was accompanied by a microglia response and could be prevented by the local intravitreal application of the anti-inflammatory agent dexamethasone. Interestingly, the level of neuronal activity after optic nerve crush as evidenced by thallium autometallography was enhanced in the termination area of the uncrossed projection, the rostro-medial superior colliculus, suggesting that a dying-back mechanism is not involved. We propose that injury signals from the damaged optic nerve and retina are transduced to the unaffected eye.
Influence of Topically Applied Antimicrobial Agents on Muscular Microcirculation

Bacterial infections cause major complications in wound healing. Local antiseptics are used for daily wound care; however, their potential toxic effects on the vasculature have not yet been thoroughly investigated. The aim of this study was to assess the effects of antiseptics on microcirculation. Investigations were performed on a standardized cremaster muscle model on rats (n = 60). The arteriolar diameter and functional capillary density (FCD) were investigated using transillumination microscopy before and 60 and 120 minutes after application of each of the following antimicrobial agents: alcohol, hydrogen peroxide, imipenem, octenidine dihydrochloride, polyhexanide, and ethacridine lactate. Although polyhexanide caused a significant arteriolar dilatation (106.25 ± 3.23 vs. 88.54 ± 6.74 &mgr;m [baseline value]) and increase of FCD compared with baseline value (12.65 ± 0.82 vs. 9.10 ± 0.50 n/0.22 mm2), alcohol led to a significant decrease of both parameters (90.63 ± 10.80 vs. 52.09 ± 7.69 and 5.35 ± 0.54 vs. 1.68 ± 0.48) and was the only agent that caused arteriolar thrombosis. The FCD also increased significantly after treatment with hydrogen peroxide (10.55 ± 0.33 vs. 12.30 ± 0.48) and octenidine (6.82 ± 0.63 vs. 12.32 ± 0.63). However, no positive effect on arteriolar diameter could be found. Ethacridine lactate and imipenem did not impact either parameter. In addition to reducing bacteria, an antiseptic should be nontoxic, especially to the microcirculation. Polyhexanide seems to have a positive influence on vessel diameter and capillary density, whereas alcohol reduces both parameters. If the antimicrobial efficacy is comparable, the antiseptic with less toxic effects should be chosen, especially in critically perfused wounds.
An Interesting Tetrad of Asplenia, Inflammation, Hemolysis, and Nephritis

Heme oxygenase-1 (HO-1) is a vital enzyme that is increasingly emerging as a central player in diseases involving major organ systems [1]. HO-1 enzyme has been found to have antioxidant and anti-inflammatory properties. It is cytoprotective and is important in modulating tissue response to injury in several pathological states [2]. To date, only 2 cases of human HO-1 deficiency have been reported [3, 4]. Both cases presented with a tetrad of hemolysis, inflammation, nephritis, and asplenia.
Modulatory effect of monosodium glutamate on rat thymocyte proliferation and apoptosis.

BACKGROUND Monosodium glutamate (MSG) is the sodium salt of glutamic acid, widely spread in modern nutrition. Numerous recent studies have shown the existence of glutamic receptors on different nonneuronal cells, which among others also include lymphocytes and thymocytes. OBJECTIVES The current study was designed to evaluate the prolonged effect of MSG on rat thymocyte proliferation, apoptosis and expression of two apoptosis related proteins, Bel-2 and Bax. MATERIAL AND METHODS Wistar rats (male) were exposed to monosodium glutamate (MSG) (4 mg/g body wt, i.p.) for 6 consecutive days and sacrificed on 30th and 45th day after last MSG dose. Thymocyte proliferation was evaluated by measuring the expression of proliferating cell nuclear antigen by flow cytometry. Apoptosis was detected using the Annexin V-FITC/PI apoptosis detection kit and cells were analyzed using a flow cytometer. Expression of Bcl-2 and Bax proteins were determined with flow cytometry using respective monoclonal antibodies. RESULTS The current study results demonstrate that MSG significantly decreased thymocyte proliferation (p < 0.001) induced by ConA and increased apoptosis rate (p < 0.001) of the cells during examination period. MSG treatment induced down regulation of Bcl-2 protein while Bax protein levels were not significantly changed. CONCLUSION These results indicate that MSG significantly modulates thymocyte proliferation by modulating the apoptosis rate of the cells. The temporal profile of Bcl-2 and Bax expression, after MSG treatment, suggest that down regulation of Bcl-2 protein and resulting change of Bcl-2/Bax protein ratio may be an important event in thymocyte apoptosis, triggered by MSG (Tab. 1, Fig. 3, Ref. 36).
The effect of collagenase and trypsin on collagen. An electron microscopic study

Banfield ('52) has recently drawn attention to the presence of collagen fibrils with tapered ends in sites where collagen was apparently being actively formed (embryonic human tissue and mesenchymal neoplasms). In preparations of adult tissue such fibrils were rare or absent. Randall, Fraser, Jackson, Martin and North ( '52) reported tapered collagen fibrils from the umbilical cord of the rat and suggested that collagen fiber growth may take place by a process of pyramidal accretion. Noda and Wyckoff' ('51) noted fibrils terminating at one or both ends as cones tapering to a point in reprecipitated collagen using citrate buffer a t pH 4.6. Gross ( '53) illustrated collagen fibrils with tapered ends following 4 hours' action of collagenase supplied by Dr. J. D. MacLennan (Nandl; MacLeiiiian and Howes, ' 5 3 ) . This paper describes the results of this same enzyme on humaii skin and tendon and on calves' tendon. The qualitative changes found under the electron microscope resemble the stages of collagen synthesis reported in the literature. It is possible, therefore, that enzyne break-down may shed light on the visible component parts or building fragments of collagen. Concurrent quantitative chemical determinations will be reported elsewhere. In addition, the effects of various
Knowledge Management: Linking People to Knowledge for Bottom Line Results

Executives in large organizations know that they must develop better techniques to manage their greatest asset: knowledge. Organizations currently create and maintain knowledge in isolated systems targeted at specific workgroups. For users outside the workgroup, that knowledge is virtually invisible. Vendors of all manner of tools, from intranet development tools to document management systems to search engines, are calling their products Knowledge Management systems, without regard to what that means. Without new technologies to create revolutionary change in the way knowledge workers create, communicate and manage information, a Knowledge Management system has little chance of improving enterprise knowledge sharing. This paper explores the concepts and technologies associated with an effective Knowledge Management system.
IN-SITU STRESS IN A FA JLT-HOSTED GEOTHERMAL RESERVOIR AT DIXIE VALLEY , NEVADA

As part of a study relating fractured rock hydrology to in-situ stress and recent deformation within the Dixie Valley Geothermal Field, borehole televiewer logging and hydraulic fracturing stress measurements were conducted in a 2.7-km-deep geothermal production well (73B-7) drilled into the Stillwater fault zone. The borehole televiewer logs from well 73B-7 show numerous drilling-induced tensile fractures, indicating that the direction of the minimum horizontal principal stress, S h m i n , is S57"E k 10". As the Stillwater fault at this location dips S50"E at -53", it is nearly at the optimal orientation for normal faulting in the current stress field. Analysis of the hydraulic fracturing data shows that the magnitude of &,,,in is 24.1 and 25.9 MPa at 1.7 and 2.5 km, respectively. Analysis of a hydraulic fracturing test from a shallow water well (24W-5) 1.5 km northeast of 73B-7 indicates that the magnitude of &,,,in is 5.6 MPa at 0.4 km depth. Given the calculated vertical stress, Coulomb failure analysis indicates that the magnitude of &,,,in measured in these wells is close to that predicted for incipient normal faulting on the Stillwater and other subparallel faults, using laboratory-derived coefficients of friction of 0.6 to 1 . O and estimates of the in-situ formation fluid pressure.
Longitudinal and Sex Measurement Invariance of the Affective Neuroscience Personality Scales

The Affective Neuroscience Personality Scales (ANPS) is a personality instrument based on six evolutionary-related brain systems that are at the foundation of human emotions and behaviors: SEEKING, CARING, PLAYFULNESS, FEAR, ANGER, and SADNESS. We sought to assess for the short and long versions of the ANPS: (a) the longitudinal measurement invariance and long-term (4-year) stability and (b) the sex measurement invariance. Using data from a Canadian cohort (N = 518), we used single-group confirmatory factor analysis to assess longitudinal invariance and multiple-group confirmatory factor analysis to assess sex invariance, according to a five-step approach evaluating five invariance levels (configural, metric, scalar, residual, and complete). Results supported full longitudinal invariance for both versions for all invariance levels. Partial residual invariance was supported for sex invariance. The long-term stability of both versions was good to excellent. Implications for personality assessment and ANPS development are discussed.
Expression of the Epidermal Growth Factor Receptor in Human Small Cell Lung Cancer Cell Lines 1

Epidermal growth factor (EGF) receptor expression was evaluated in a panel of 21 small cell lung cancer cell lines with radioreceptor assay, affinity labeling, and Northern blotting. We found high-affinity receptors to be expressed in 10 cell lines. Scatchard analysis of the binding data demonstrated that the cells bound between 3 and 52 fmol/mg protein with a ADranging from 0.5 x IO'10 to 2.7 x IO"10M. EGF binding to the receptor was confirmed by affinity-labeling EGF to the EGF receptor. The cross-linked complex had a M, of 170,000-180,000. Northern blotting showed the expression of EGF receptor mRNA in all 10 cell lines that were found to be EGF receptor-positive and in one cell line that was found to be EGF receptor-negative in the radioreceptor assay and affinity labeling. Our results provide, for the first time, evidence that a large proportion of a broad panel of small cell lung cancer cell lines express the EGF receptor.