Miracle-dz/UniFAR-FTUs huggingface dataset:
SGLT-2 inhibitors in non-alcoholic fatty liver disease patients with type 2 diabetes mellitus: A systematic review

BACKGROUND Non-alcoholic fatty liver disease (NAFLD) is a common comorbidity with type 2 diabetes. The existing therapeutic options for NAFLD are not adequate. Hypocaloric diet and exercise is the cornerstone of therapy in NAFLD. Pioglitazone is the only drug recommended in diabetes patients with biopsy proven non-alcoholic steatohepatitis. The frequent coexistence of NAFLD and type 2 diabetes with their combined adverse health consequences and inadequate therapeutic options makes it necessary to search for newer alternatives. AIM To assess the effect of sodium glucose cotransporter-2 (SGLT-2) inhibitors on liver enzymes in type 2 diabetes patients with NAFLD. METHODS We searched PubMed/MEDLINE, Cochrane library, Google scholar, and Clinicaltrials.gov for the relevant articles to be included in this systematic review. Human studies done in type 2 diabetes patients with NAFLD treated with SGLT-2 inhibitors for at least 12 wk were included. Data from eight studies (four randomised controlled trials and four observational studies) were extracted and a narrative synthesis was done. A total of 214 patients were treated with SGLT-2 inhibitors in these studies (94 in randomised controlled trials and 120 in observational studies). RESULTS The primary outcome measure was change in serum alanine aminotransferase level. Out of eight studies, seven studies showed a significant decrease in serum alanine aminotransferase level. Most of the studies revealed reduction in serum level of other liver enzymes like aspartate aminotransferase and gamma glutamyl transferase. Five studies that reported a change in hepatic fat exhibited a significant reduction in hepatic fat content in those treated with SGLT-2 inhibitors. Likewise, among the three studies that evaluated a change in indices of hepatic fibrosis, two studies revealed a significant improvement in liver fibrosis. Moreover, there was an improvement in obesity, insulin resistance, glycaemia, and lipid parameters in those subjects taking SGLT-2 inhibitors. The studies disclosed that about 17% (30/176) of the subjects taking SGLT-2 inhibitors developed adverse events and more than 40% (10/23) of them had genitourinary tract infections. CONCLUSION Based on low to moderate quality of evidence, SGLT-2 inhibitors improve the serum level of liver enzymes, decrease liver fat, and fibrosis with additional beneficial effects on various metabolic parameters in type 2 diabetes patients with NAFLD.
The implications of refuge requirements for Bt cotton in India on world cotton markets

The study evaluated the potential impacts of refuge requirements for Bt cotton in India on world cotton markets. The objective was accomplished by estimating regional cotton yield functions in the Indian fiber model, and connecting it with rest of the world fiber model. Results revealed that the refuge requirements have potential to impact world cotton markets; magnitudes of impacts are smaller, however. The world cotton trade would be lower, and the cotton prices would be higher under higher refuge requirements, and vice versa. As the refuge requirements for an insecticidal Bt technology depend on its replacement rate, the time spent in R&D and regulation of the technology has implications for Bt crops refuge requirements and world commodity markets. Key words: Bt cotton, India, refuge requirements, world cotton markets, world fiber model.
Care technologies to prevent and control hemorrhage in the third stage of labor: a systematic review

Objective to identify evidence concerning the contribution of health technologies used to prevent and control hemorrhaging in the third stage of labor. Method systematic review with database searches. First, two researchers independently selected the papers and, at a second point in time, held a reconciliation meeting. The Kappa coefficient was used to assess agreement, while the Grading of Recommendations, Assessment, Development and Evaluation was adopted to assess risk of bias and classify level of evidence. Results in this review, 42 papers were included, 34 of which addressed product technologies, most referred to pharmacological products, while two papers addressed the use of blood transparent plastic bags collector and the contribution of birth spacing and prenatal care. The eight papers addressing process technologies included the active management of the third stage of labor, controlled cord traction, uterine massage, and educational interventions. Conclusion product and process technologies presented high and moderate evidence confirmed in 61.90% of the papers. The levels of evidence confirm the contribution of technologies to prevent and control hemorrhaging. Clinical nurses should provide scientific-based care and develop protocols addressing nursing care actions.
Page 1 of 18 A narrative inquiry into the role of advocacy and activism amongst mothers with a child diagnosed with an Autism Spectrum Disorder

This is a qualitative study into the role of advocacy and activism amongst mothers who have a child diagnosed with an Autism Spectrum Disorder (ASD). Previous research specifically examining this subject recognises it as a development to combat societal isolation (Ryan and Runswick-Cole, 2009; Woodgate et al., 2008). This study seeks to examine the concept further. Five mothers participated in a Free Association Narrative Interview (FANI) to gain an understanding of experiences related to advocacy and activism. The participants were obtained through a snowball sample, whereby personal links were utilised. It demonstrates the importance of advocacy and activism to the participants and their children. A thematic analysis identified three key emerging themes. Namely, developing supportive relationships, negotiating educational approaches and preparing for their children’s future.
Volovik effect in a highly anisotropic multiband superconductor: Experiment and theory

We present measurements of the specific heat coefficient $\ensuremath{\gamma}$ ($\ensuremath{\equiv}C/T)$ in the low-temperature limit as a function of an applied magnetic field for the Fe-based superconductor BaFe${}_{2}$(As${}_{0.7}$P${}_{0.3}$)${}_{2}$. We find both a linear regime at higher fields and a limiting square root $H$ behavior at very low fields. The crossover from a Volovik-like $\sqrt{H}$ to a linear field dependence can be understood from a multiband calculation in the quasiclassical approximation assuming gaps with different momentum dependence on the hole- and electronlike Fermi surface sheets.
Cotyledonoid dissecting leiomyoma: an uncommon form of a common disease

Leiomyomas are benign uterine smooth muscle neoplasms with varied morphology that are well known to undergo secondary changes. Cotyledonoid dissecting leiomyoma is a rare and distinct form of leiomyoma that poses a diagnostic challenge for clinicians, radiologists, and pathologists and can be confused with malignant uterine neoplasms. Only a few cases have been reported so far in the literature. Here we report a case of a cotyledonoid dissecting leiomyoma in a 60-year-old woman, emphasize its gross and histological features, and provide a review of the literature.
Rapid carbon cycling in the oligotrophic ocean

Rapid carbon cycling in the oligotrophic ocean C. M. Duarte and S. Agusti Department of Global Change Research, IMEDEA (CSIC-UIB), Instituto Mediterraneo de Estudios Avanzados, Miquel Marques 21, 07190 Esporles, Spain The UWA Oceans Institute, University of Western Australia, 35 Stirling Highway, Crawley 6009, Australia The UWA Oceans Institute and School of Plant Biology, University of Western Australia, 35 Stirling Highway, Crawley 6009, Australia
Genetic analysis of productive and reproductive traits in multiple-breed dairy cattle populations

The objective of this work was to determine whether the random regression model using linear splines (RRMLS) is suitable to estimate the genetic parameters for productive and reproductive traits of a multiple-breed dairy cattle population, as well as to investigate the effect of the genetic group of the progeny on the genetic merit of the sire. The multiple-trait model (MTM) and the RRMLS with one knot fitted for every genetic group were used to obtain the genetic parameters. Records of 1/2 Holstein + 1/2 Gyr (1/2HG), 5/8 Holstein + 3/8 Gyr (5/8HG), and 3/4 Holstein + 1/4 Gyr (3/4HG) crossbreed dams were considered. The RRMLS showed better fitting. The additive and residual variances estimated by the MTM and the RRMLS were similar. Heritability varied from 0.20 to 0.33 for age at first calving, from 0.09 to 0.22 for first lactation length, and from 0.15 to 0.35 for first lactation 305-day milk yield, according to the genetic composition of the dams. The RRMLS is suitable to estimate the genetic parameters for productive and reproductive traits of multiple-breed dairy cattle populations. The genetic merit of the sires is affected by the genetic group of the progeny by which they are evaluated.
Screening for red flag symptoms of cancer: A community-based cross-sectional study from urban Puducherry, India

BACKGROUND: Patients with cancer often delay seeking medical advice in developing countries. In India, only 20%–30% of cancers are being diagnosed in Stages I and II. Screening for red flag symptoms of cancer can be used to identify high-risk individuals in the community. METHODOLOGY: A community-based cross-sectional study was conducted in February 2017 among 302 participants in one of the service areas of Jawaharlal Institute of Postgraduate Medical Education and Research urban health center selected by universal sampling. Data on the presence of red flag symptoms of cancer (persistent cough, persistent change in bowel/bladder habits, nonhealing ulcer, persistent difficulty in swallowing, unexplained weight loss, unexplained lump, persistent unexplained pain, unexplained bleeding, and change in the appearance of mole) and presence of risk factors were collected through interviews. The collected data were entered using EpiData version 3.0. RESULTS: The mean (standard deviation) age of the study participants was 44 (11) years and 50.6% of them were male. At least one red flag symptom of cancer was present in 22 (7.3%) individuals; 9 (2.8%) had unexplained pain, 4 (1.3%) had change in bowel habits, 4 (1.3%) had change in bladder habits, 3 (1%) had cough, 3 (1%) had nonhealing ulcer, 2 (0.6%) had unexplained bleeding, 1 (0.3%) had difficulty in swallowing, 1 (0.3%) had weight loss, 1 (0.3%) had lump, and 1 (0.3%) had change in the appearance of mole. CONCLUSION: Screening for red flag symptoms of cancer is an easy tool that can be used in the community to identify high-risk individuals, which will facilitate early diagnosis of cancer.
TYPES AND RISK FACTORS OF FIRST TIME STROKE: A SAUDI HOSPITAL- BASED STUDY

Background: The purpose of this study was to explore the stroke types and the risk factors of the first-time stroke in the holy city of Madinah Munawarah.Methods: A prospective hospital-based research study was carried out over the year of 2014. The patients with the diagnosis of the cerebrovascular accident were enrolled in the study. The details of patients’ history, demographic data, stroke type, and risk factors were collected.Results: First-time stroke were determined in 164 patients (91 male and 73 female) during the entire periods of this study with a mean age of 67.52 ± 2.31 years. The prevalence of types of stroke was ischaemic strokes in 133 patients(% 81.1), intercerebral hemorrhage in 24 patients (14.63%), and subarachnoid hemorrhage in one patient (0.6%). The most common risk factors recorded were hypertension (86.6%), diabetes mellitus (63.4%), and ischaemic heart disease (41.5%). There was no significant relationship between the frequency of ischaemic stroke and intercerebral hemorrhagestroke ( p> 0.05). Conclusion: The study indicates that hypertension, diabetes, and ischaemic heart disease are critical risk factors for developing stroke and fairly commensurate with the global reported risk factors. Further research is needed to investigate stroke patterns and other possible risk factors concurrently with Saudi national prevention programs.
An Integrated SEM-Neural Network Approach for Predicting Determinants of Adoption of Wearable Healthcare Devices

The advancement in wireless sensor and information technology has offered enormous healthcare opportunities for wearable healthcare devices and has changed the way of health monitoring. Despite the importance of this technology, limited studies have paid attention for predicting individuals’ influential factors for adoption of wearable healthcare devices. The proposed research aimed at determining the key factors which impact an individual's intention for adopting wearable healthcare devices. The extended technology acceptance model with several external variables was incorporated to propose the research model. A multi-analytical approach, structural equation modelling-neural network, was considered for testing the proposed model. The results obtained from the structural equation modelling showed that the initial trust is considered as the most determinant and influencing factor in the decision of wearable health device adoption followed by health interest, consumer innovativeness, and so on. Moreover, the results obtained from the structural equation modelling applied as an input to the neural network indicated that the perceived ease of use is one of the predictors that are significant for adoption of wearable health devices by consumers. The proposed study explains the wearable health device implementation along with test adoption model, and their outcome will help providers in the manufacturing unit for increasing actual users’ continuous adoption intention and potential users’ intention to use wearable devices.
A new framework for detecting the short term fiscal vulnerability for the European Union countries

The aim of this study is to develop a new framework (V-L-D) for detecting the short term vulnerabilities in fiscal policy for the European Union countries. The methodology relies ontwo distinct indicators: one showing the vulnerabilities signalled by the size of the cyclically adjusted budget and public debtand one indicatingthe vulnerabilities through their annual changes.V-L-D is able to categorize fiscal vulnerability into five distinct classes having scores from 0 (no fiscal vulnerability) to 4 (extreme fiscal vulnerability). From 1990-2013, we found310 episodes of fiscal vulnerability for the 28 European Union countries out of which 128 episodes of low vulnerability, 94 of moderate, 62 of strong and 26 of extreme fiscal vulnerability. We also explored the correlation between financial market sentiment and fiscal vulnerability. We used V-L-D as a predictor and Credit Default Swaps (CDS)as dependent and proxy for the market sentiment in a balanced panel model consisting in 17 European countries with random effects over the period 2008-2013. The results indicatethat CDS are higher and significant for strong and extreme vulnerability periodscompared with times having zero vulnerability. The CDS for low and moderate fiscal vulnerabilityare also higher but they are not significant, suggesting that investorsoverprice the risk randomly during low and moderate vulnerability.Employing a logit model for a panel consisting of 12 European countries over 2008-2013, we also found that governments are less likely to adjust fiscal policy when it is strong or extremely vulnerable and that the probability of fiscal consolidation increaseswhen market sentiment is negative and CDS are higher.
FERTIGATION OF HIGHBUSH BLEUEBERRY (Vaccinium corymbosum L.). PART III. THE EFFECT ON NUTRIENT CONTENTS IN LEAVES

Fertigation with the nutrient solutions containing macro and microelements could influence on the nutrient status of highbush blueberry. Studies were conducted in the years 2002-2004 on a 10-year old plantation of highbush blueberry cv. 'Bluecrop'. The aim was to analyze the effect of fertigation using 3 nutrient solutions (F-1, F-2, F-3) in comparison to drip irrigation (F-0) on the contents of macro- and microelements as well as sodium and aluminium in leaves. Fertigation with nutrient solutions F-1, F-2 and F-3 in relation to drip irrigation (F-0) increased the contents of nitrogen, potassium and calcium in the leaves of highbush blueberry cv. 'Bluecrop' at both terms of leaves collection (15.06 and 15.07) while it reduced the content of magnesium with the application of nu- trient solutions F-2 and F-3 at the second term of study. No distinct effect of fertigation on the contents of phosphorus and sulphur in leaves was found. Among microelements the greatest effect of fertigation was indicated for boron. Nutrient solutions F-2 and F-3 at the first term as well as F-1, F-2 and F-3 at the second one increased boron content in leaves. Fertigation was found to have an effect on the increase of manganese and copper contents at the term II and zinc at the term I. No variation was recorded in iron content in leaves under the influence of fertigation. Fertigation reduced the content of aluminium in leaves of highbush blueberry. The effect was shown mainly under the influence of the applica- tion of nutrient solution F-2. Contents of N, P, K, Zn, Na and B decreased but Ca, Mg, Fe, Mn and Al increased in leaves between the first (15.06) and second II (15.07) term of study. No changes were found in contents of S or Cu in leaves of highbush blueberry at both sampling terms. For the evaluation of highbush blueberry nutrition status in Poland the term II seems to be more advantageous. It is the second half of July, after the first har- vest of cv. "Bluecrop". In this period there is the stabilization of vegetative growth with marked effects of bushes yielding.
RISK AND RETURN IN THE REAL ESTATE, BOND AND STOCK MARKETS

Abstract Studies investigating the relation between risk and return occupy an important place in the discussion about the effectiveness of investing in real estate. A review of the available studies shows that real estate investments are less profitable than stocks, but in terms of risk and return, are usually the best option. This worldwide regularity may not necessarily be presented in Poland, as the Polish market is not fully fledged yet. The analysis presented in this article was performed with a view to reducing a research gap resulting from the lack of comprehensive Polish studies in this field. In the article, data spanning the years from 2006 to 2016 are examined by means of descriptive statistics, measures of risk, and the analysis of variance (ANOVA) to determine which of the following investment vehicles - bonds, real estate or stocks - offer the best risk-return ratio. The article has two parts. The analytical part is a review of studies on risk measurement methods and of earlier studies investigating risk and return by a class of assets (particularly real estate). In the empirical part, assets are compared with the use of statistical methods. The results of the risk-return analysis point to the money market as the best option for investors. Stocks and real estate ranked second and third, respectively.
DILIP SOMAN and AMAR CHEEMA

This research examines the effects of earmarking money on savings by low-income consumers. In particular, the authors test two interventions that are designed to enhance the effects of earmarking: (1) using a visual reminder of the savings goal and (2) dividing the earmarked money into two parts. Consistent with prior research suggesting that partitioning increases self-control, people save more when earmarked money is partitioned into two accounts than when it is pooled into one account. In addition, the presence of the visual reminder increases the savings rate. The authors conclude with implications for consumer welfare and directions for further research.
Fish production of a temperate artificial reef based on the density of embiotocids (Teleostei: Perciformes)

The abundance of two embiotocids (Embiotoca jacksoni and Rhacochilus vacca) was surveyed continually from 1974 to 1998 on the breakwaters comprising King Harbor in Redondo Beach, California, and a nearby natural rocky-reef as a reference. Embiotocids provide an interesting model for reef-fish production because they are viviparous and their entire ontogeny can be observed on the reefs. We deduce that the two reef populations of both species were stable at their carrying capacity. This carrying capacity was greater in King Harbor throughout the study. We also report a linear decline in survival of juveniles of both species over the 25-year period. Overall regional processes were similar on the two reefs, yet temporal differences suggested that they were acting independently. The King Harbor reefs produced greater biomass for both species, which represents one factor explaining the higher density of kelp bass (Paralabrax clathratus), an important predator.Copyright 2002 International Council for the Exploration of the Sea. Published by Elsevier Science Ltd. All rights reserved.
National Convention of the Association for Educational Communications and Technology

The purpose of this study was to investigate the effect of implementing cooperative learning and objectives with computer-based instruction (CBI). Subjects were 125 fifth and sixth grade students. Cooperative dyads and individuals worked through a CBI earth science program that contained either instructional objectives, advance organizers, or no orienting activities. Results indicated that students who received instructional objectives performed significantly better on intentional posttest items than students who received either advance organizers or no orienting activities. Results also revealed that dyads who received objectives exhibited significantly more on-task group behaviors, more helping behaviors, and fewer off-task behaviors than dyads in the other orienting activity conditions. Furthermore, learning strategy influenced time on task; individuals spent significantly more time on instruction and practice than cooperative dyads. Implications for CBI developers are explored. (Contains 52 references.) (Author/MES) Reproductions supplied by EDRS are the best that can be made from the original document. Using Cooperative Learning and Objectives with Computer-Based Instruction PERMISSION TO REPRODUCE AND DISSEMINATE THIS MATERIAL HAS BEEN GRANTED BY
Cored density profiles in the DARKexp model

The DARKexp model represents a novel and promising attempt to solve a long standing problem of statistical mechanics, that of explaining from first principles the quasi-stationary states at the end of the collisionless gravitational collapse. The model, which yields good fits to observation and simulation data on several scales, was originally conceived to provide a theoretical basis for the 1/r cusp of the Navarro-Frenk-White profile. In this note we show that it also allows for cored density profiles that, when viewed in three dimensions, in the r→0 limit have the conical shape characteristic of the Burkert profile. It remains to be established whether both cusps and cores, or only one of the two types, are allowed beyond the asymptotic analysis of this work.