Miracle-dz/UniFAR-FTUs huggingface dataset:
Telomerase activity in peripheral blood mononuclear cells from patients with SLE.

Y. Antinuclear antibodies in localized scleroderma. Arthritis Rheum 1983;26:612–16. 3 Falanga V, Medsger TA Jr, Reichlin M, Rodnan GP. Linear scleroderma: clinical spectrum, prognosis, and laboratory abnormalities. Ann Intern Med 1986;104:849–57. 4 Takehara K, Kikuchi K, Soma Y, Igarashi A, Ishibashi Y. Anti-single-strand DNA antibody and muscle involvement in localized scleroderma. Arch Dermatol 1990;126:1368–9. 5 Sato S, Ihn H, Soma Y, Igarashi A, Tamaki T, Kikuchi K, et al. Antihistone antibodies in localized scleroderma. Arthritis Rheum 1993; 36:1137–41. 6 Reimer G, Steen VD, Penning CA, Medsger TA Jr, Tan EM. Correlates between autoantibodies to nucleolar antigens and clinical features in patients with systemic sclerosis (scleroderma). Arthritis Rheum 1988;31:525–32. 7 Kipnis RJ, Craft J, Hardin JA. The analysis of antinuclear and antinucleolar autoantibodies of scleroderma by radioimmunoprecipitation assays. Arthritis Rheum 1990;33:1431–7. 8 Kuwana M, Kaburaki J, Mimori T, Tojo T, Homma M. Autoantibody reactive with three classes of RNA polymerases in sera from patients with systemic sclerosis. J Clin Invest 1993;91:1399–404. 9 Okano Y, Steen VD, Medsger TA Jr. Autoantibody to U3 nucleolar ribonucleoprotein (fibrillarin) in patients with systemic sclerosis. Arthritis Rheum 1992;35:95–100. 10 Reimer G, Rose KM, Scheer U, Tan EM. Autoantibody to RNA polymerase I in scleroderma sera. J Clin Invest 1987;79:65–72.
Ocean circulation and properties in Petermann Fjord, Greenland

The floating ice shelf of Petermann glacier interacts directly with the ocean and isthought to lose at least 80% of its mass through basal melting. Based on three opportunisticocean surveys in Petermann Fjord we describe the basic oceanography: the circulationat the fjord mouth, the hydrographic structure beneath the ice shelf, the oceanic heatdelivered to the under‐ice cavity, and the fate of the resulting melt water. The 1100 m deepfjord is separated from neighboring Hall Basin by a sill between 350 and 450 m deep.Fjord bottom waters are renewed by episodic spillover at the sill of Atlantic water from theArctic. Glacial melt water appears on the northeast side of the fjord at depths between200 m and that of the glacier’s grounding line (about 500 m). The fjord circulation isfundamentally three‐dimensional; satellite imagery and geostrophic calculations suggest acyclonic gyre within the fjord mouth, with outflow on the northeast side. Tidal flowsare similar in magnitude to the geostrophic flow. The oceanic heat flux into the fjordappears more than sufficient to account for the observed rate of basal melting. Cold,low‐salinity water originating in the surface layer of Nares Strait in winter intrudes farunder the ice. This may limit basal melting to the inland half of the shelf. The melt rate andlong‐term stability of Petermann ice shelf may depend on regional sea ice cover andfjord geometry, in addition to the supply of oceanic heat entering the fjord.
Effect of Gamma Rays and Salinity on Growth and Chemical Composition of Ambrosia maritima L . Plants

This work was achieved in pots at the wire house of the National Center for Radiation Research and Technology (NCRRT) during the two successive seasons of 2007/2008 and 2008/2009. The aim of this experiment was to study the effect of gamma irradiation doses (0, 20, 40 and 80 Gy) on damssisa plants (Ambrosia maritima L.) under salt stress after sowing in (3:2, sand: loamy) soils with mixture of salts. The mixture of salts was sodium chloride, calcium chloride and magnesium sulfate at the ratio of 2:2:1. Three concentrations of the used mixture were prepared; 2000, 4000 and 6000 ppm. It was observed that irradiation of damsissa seeds with 40 or 80 Gy increased plant tolerance to salinity comparing to control, concerning plant height, fresh & dry weights and photosynthetic pigments. This increase was often significant with low concentration of salinity. On the other hand, sowing seeds in 6000 ppm concentration decreased all the previous measurements. Also, it was noticed that radiation alleviates the adverse effect of salinity by increasing total sugar and total soluble phenols in shoots of damsissa plants.
Human Bite Injuries: A Five-Year Retrospective Review of Cases from A Semi-Urban Area of Bayelsa State, Nigeria.

Human bite injuries are common presentation in the Accident and Emergency room. They are often under reported, present late, and are characterized by soft tissue complications and severe mixed synergistic infections derived from the mouth of the assailant or the skin of the victim. Staphylococcus aureus is isolated in 30% of cases, the hand is commonly affected and there is a risk of transmission life threatening infections like hepatitis B, hepatitis C and to a lesser extent HIV, tetanus, actinimycosis, and treponoma palladium. Despite antibiotic use these patients still develop advanced wound infections, and sometimes life threatening complications. We have therefore undertaken this retrospective study is to review the pattern, bacteriology and complications of HBI in our environment. This is a retrospective study in which case notes of patients who had human bite injuries at Divine Grace Medical Center Okolobiri Bayelsa State Nigeria from January 2010 to December 2015 were reviewed and the obtained data analyzed. Simple descriptive statistics and tables were used to present results. Sixty-five (65) patients were studied with a male: female of 1:1; twenty-three (23(35.384 %)) of all human bite injuries occurred in the hand. Wound infection was the commonest complication. The patients had multiple clinical presentations, with pain, bleeding, swelling, purulent discharge, fever and chills being the commonest. Staphylococcus aureus was the most common organism 16(24.615%) isolated, and most were resistance to antibiotics like penicillin ampicillin, cloxacillin. Early clinical evaluation, diagnosis, treatment and the use of appropriate antibiotic coupled with detailed surgical assessment are the key to achieving good treatment outcome.
Critical Role of Calbindin-D28k in Calcium Homeostasis Revealed by Mice Lacking Both Vitamin D Receptor and Calbindin-D28k*

Calbindin (CaBP)-D28k and CaBP-D9k are cytosolic vitamin D-dependent calcium-binding proteins long thought to play an important role in transepithelial calcium transport. However, recent genetic studies suggest that CaBP-D28k is not essential for calcium metabolism. Genetic ablation of this gene in mice leads to no calcemic abnormalities. Genetic inactivation of the vitamin D receptor (VDR) gene leads to hypocalcemia, secondary hyperparathyroidism, rickets, and osteomalacia, accompanied by 90% reduction in renal CaBP-D9k expression but little change in CaBP-D28k. To address whether the role of CaBP-D28k in calcium homeostasis is compensated by CaBP-D9k, we generated VDR/CaBP-D28k double knockout (KO) mice, which expressed no CaBP-D28k and only 10% of CaBP-D9k in the kidney. On a regular diet, the double KO mice were more growth-retarded and 42% smaller in body weight than VDRKO mice and died prematurely at 2.5–3 months of age. Compared with VDRKO mice, the double KO mice had higher urinary calcium excretion and developed more severe secondary hyperparathyroidism and rachitic skeletal phenotype, which were manifested by larger parathyroid glands, higher serum parathyroid hormone levels, much lower bone mineral density, and more distorted growth plate with more osteoid formation in the trabecular region. On high calcium, high lactose diet, blood-ionized calcium levels were normalized in both VDRKO and the double KO mice; however, in contrast to VDRKO mice, the skeletal abnormalities were not completely corrected in the double KO mice. These results directly demonstrate that CaBP-D28k plays a critical role in maintaining calcium homeostasis and skeletal mineralization and suggest that its calcemic role can be mostly compensated by CaBP-D9k.
Transitions in Distinct Histone H3 Methylation Patterns at the Heterochromatin Domain Boundaries

Eukaryotic genomes are organized into discrete structural and functional chromatin domains. Here, we show that distinct site-specific histone H3 methylation patterns define euchromatic and heterochromatic chromosomal domains within a 47-kilobase region of the mating-type locus in fission yeast. H3 methylated at lysine 9 (H3 Lys9), and its interacting Swi6 protein, are strictly localized to a 20-kilobase silent heterochromatic interval. In contrast, H3 methylated at lysine 4 (H3 Lys4) is specific to the surrounding euchromatic regions. Two inverted repeats flanking the silent interval serve as boundary elements to mark the borders between heterochromatin and euchromatin. Deletions of these boundary elements lead to spreading of H3 Lys9 methylation and Swi6 into neighboring sequences. Furthermore, the H3 Lys9methylation and corresponding heterochromatin-associated complexes prevent H3 Lys4 methylation in the silent domain.
EFFECT OF LITTER SUBSTRATES ON THE PERFORMANCE, CARCASS TRAITS, AND ENVIRONMENTAL COMFORT OF RED-WINGED TINAMOU (RHYNCHOTUS RUFESCENS)

The study aimed at evaluating the effect of litter substrates on the performance, carcass traits, and environmental comfort of red-winged tinamou (Rhynchotus rufescens). In this experiment, 160 birds, with 100 and 300 days of age, were housed into 20 pens, and distributed according to a completely randomized experimental design into five treatments with four replicates of eight birds each. Treatments consisted of five litter substrates: wood shavings, rice husks, peanut hulls, grass hay, or sand. Feed intake; weight gain; breast, hock, and footpad lesions; back feathering; total meat production; carcass and parts yield; and leukocyte counts were evaluated. Litter substrates were analyzed for dry matter content, standard microbial count, ammonia volatilization potential, water content, water holding capacity, temperature, and radiant heat load. The results showed that litter substrate did not influence the evaluated bird parameters, despite the higher microbial counts and released ammonia values determined in peanut hulls and sand, respectively. Sand also tended to have higher average temperature than the other litter substrates. It was concluded that litter substrate should be chosen at farmer discretion, taking into consideration its cost and utilization after use.
Update of the 1972 Singer-Nicolson Fluid-Mosaic Model of Membrane Structure

The Fluid-Mosaic Membrane Model of cell membrane structure was based on thermodynamic principals and the available data on component lateral mobility within the membrane plane [Singer SJ, Nicolson GL. The Fluid Mosaic Model of the structure of cell membranes. Science 1972; 175: 720-731]. After more than forty years the model remains relevant for describing the basic nano-scale structures of a variety of biological membranes. More recent information, however, has shown the importance of specialized membrane domains, such as lipid rafts and protein complexes, in describing the macrostructure and dynamics of biological membranes. In addition, membrane-associated cytoskeletal structures and extracellular matrix also play roles in limiting the mobility and range of motion of membrane components and add new layers of complexity and hierarchy to the original model. An updated Fluid-Mosaic Membrane Model is described, where more emphasis has been placed on the mosaic nature of cellular membranes where protein and lipid components are more crowded and limited in their movements in the membrane plane by lipid-lipid, protein-protein and lipid-protein interactions as well as cell-matrix, cell-cell and cytoskeletal interactions. These interactions are important in restraining membrane components and maintaining the unique mosaic organization of cell membranes into functional, dynamic domains.
Proteic expression of p53 and cellular proliferation in oral leukoplakias.

OBJECTIVES We intend to know the protein expression of genetic alterations that take place in the early stages in the field cancerization of oral cavity in our means as well as to study the cellular proliferation by means of Ki-67 and the protein product expression of p53 to value if the alterations in the protein products expression of these markers happen in a sequential pathway through the different stages in the field cancerization of oral cavity. MATERIALS AND METHODS A study was made by immunohistochemistry on 53 patients that presented lesions of oral leukoplaquia, assisted by the ENT service at University Hospital of Salamanca, from 1.990 up to 2000. 11 samples of normal epithelium, 15 mild to moderate dysplasias, 15 in situ carcinomas and 12 microinvasive carcinomas are included in the study. RESULTS we find an increased cellular proliferation and p53 over-expression as we advance in the grade of severity histopathologic of these lesions. The most early alterations are a significant increase of cell proliferation in mild and moderate dysplasias and an increased p53 over-expression. CONCLUSIONS Oral leukoplaquia is a precancerous stage that constitutes a cancerisable lesion due to the genetic alterations that mediate in the evolution of lesion. Routine Immunohistochemical and molecular study of these lesions allow us to know the protein expression of genetic alterations that can help in the early diagnosis and treatment of this pathology, having special relevance the study of Ki-67 in early stages and p53 in advanced lesions.
Disease Severity and Effective Parasite Multiplication Rate in Falciparum Malaria

Abstract Patients presenting with severe falciparum malaria in a Bangladeshi tertiary hospital had higher total parasite burden, estimated by parasitemia and plasma PfHRP2, than uncomplicated malaria patients despite shorter fever duration. This suggests that higher parasite multiplication rates (PMR) contribute to causing the higher biomass found in severe disease. Compared with patients without a history of previous malaria, patients with previous malaria carried a lower parasite biomass with similar fever duration at presentation, suggesting that host immunity reduces the PMR.
Crecimiento físico y estado nutricional de gimnastas rítmicas de élite

Objetivo: Comparar el crecimiento fisico de peso y estatura de gimnastas de ritmicas de elite con la refe- rencia de la Organizacion mundial de la Salud y deter- minar el estado nutricional a traves de las areas mus- cular y grasa del brazo, propuestos por Frisancho. Material y metodos: Fueron estudiadas 136 gimnas- tas de ritmicas de elite de Brasil. Las atletas fueron se- leccionadas de forma no-probabilistica (intencional). Las variables antropometricas valoradas fueron peso, estatura, estatura tronco-cefalica, circunferencia del brazo relajado y pliegue tricipital del brazo derecho. El peso y estatura fueron comparados con la referencia de la Organizacion Mundial de la Salud y el estado nu- tricional fue valorado por el area muscular y grasa pro- puestos por Frisancho. Resultados: Las gimnastas muestran bajos valores de peso corporal (p<0,05) y similar estatura en rela- cion a la referencia de la OMS (p>0,05). Respecto al estado nutricional, se observo que el 13,5% se en- cuentran en riesgo de desnutricion y 12,5% con des- nutricion en funcion de la reserva de proteina. Para el caso de la reserva calorica, el 11,5% se encuentra con riesgo de desnutricion y el 12,5% con desnutricion, respectivamente. En general, las gimnastas presentan valores similares de area muscular y bajos valores de area grasa en relacion a la referencia cuando compa- rados con el p-50. Conclusion: Los resultados sugieren que las jovenes de esta modalidad deportiva presentan bajos valores de reserva calorica debido a alta intensidad de entre- namiento a los que estan expuestos.
Genetic Testing by Cancer Site: Colon (Polyposis Syndromes)

AbstractHereditary colonic polyposis conditions are all characterized by high rates of cancer, but they have diverse phenotypes, genetic heterogeneity, and assorted inheritance patterns. The most well known of these conditions include familial adenomatous polyposis, attenuated familial adenomatous polyposis, MUTYH (MutY human homolog)–associated polyposis, Peutz-Jeghers syndrome, juvenile polyposis syndrome, and Cowden syndrome. Early recognition of these conditions is not only vital for management in affected individuals, but also for prevention and early detection in at-risk relatives. Reviewed here are the genetic testing strategies for colonic polyposis, as well as an overview of characteristic features and management considerations for these syndromes.
The effect of duration of muscle denervation on functional recovery in the rat model

The effect of long‐term denervation on neuromuscular recovery was studied in a rat hind limb model. The posterior tibial nerve was transected and repaired immediately or after denervation periods of 2 weeks, or 1, 3, 6, 9, or 12 months. Six months following reconstruction excellent axonal regeneration was seen across all nerve repairs irrespective of periods of denervation. However, there was a precipitous and profound decrease in the recovery of both muscle mass and integrated motor function if the reconstruction was delayed for longer than 1 month. Rather than a progressive change proportional to the length of the denervation period, significant, more discrete changes occurred sometime after 1 month of denervation that precluded a full recovery of muscle mass. Integrated motor function quantified using walking track analysis was impaired even after immediate nerve repair. © 1997 John Wiley & Sons, Inc. Muscle Nerve 20: 858–866, 1997
Identification of the Haemophilus influenzae tolC Gene by Susceptibility Profiles of Insertionally Inactivated Efflux Pump Mutants

ABSTRACT Isogenic strains containing insertional disruptions of 10 Haemophilus influenzae Rd genes were investigated for their effects on the susceptibility of the organism to various classes of antimicrobial compounds. MIC results show that HI1462, which encodes an Escherichia coli TolC homolog, is the third component of the H. influenzae AcrAB pump.
Does More Crime Mean More Prisoners? An Instrumental Variables Approach*

This paper studies the �mechanical theory� of crime and incarceration—�the notion that changes in imprisonment are partially determined by changes in crime rates. Previous studies found scant evidence supporting the mechanical theory. These studies, however, failed to properly control for simultaneity between incarceration rates and crime rates. While more crime may lead to larger prison populations, rising incarceration rates may deter crime. To address this bias, abortion rates in the 1970s are used as an instrument for crime in later decades. Abortion rates in the 1970s are correlated with crime in the 1990s but are unlikely to be otherwise related to incarceration or prison admissions rates in the 1990s. The instrumental variables approach finds that the estimated elasticity of prison admissions with respect to crime is approximately 1, in accord with the mechanical theory. This finding has important implications for understanding trends in the U.S. prison population.
On Some Trematode Parasites from the Jackdaw, Corvus monedula in Britain

Of a total of sixteen Jackdaws examined, four were found to be infected with Trematodes. These yielded a total of five species, two of which are new to the British fauna, namely Urotocus thalonetensis and Tamerlania zarudnyi. The other parasites found were Platynosomum petiolaium, Lyperosomum longicauda and Prosthogonimus ovatus. With the exception of P. ovatus all the species are described in the text.
Characterization of high‐affinity receptors for bombesin/gastrin releasing peptide on the human prostate cancer cell lines PC‐3 and DU‐145: Internalization of receptor bound 125I‐(Tyr4) bombesin by tumor cells

Specific receptors for bombesin/gastrin releasing peptide (GRP) on the androgen‐independent human prostate cancer cell lines PC‐3 and DU‐145 were characterized. No specific binding of 125I‐[Tyr4]‐bombesin to the androgen‐dependent human prostate cancer cell line LNCaP was detectable. The binding of 125I‐[Tyr4]‐bombesin to PC‐3 and DU‐145 cells was found to be time‐ and temperature‐dependent, saturable, and reversible. Scatchard analysis revealed a single class of binding sites with high affinity (Kd 9.8 × 10−11 M for PC‐3, and 9.1 × 10‐11 M for DU‐145 cells at 25°C) and with a binding capacity of 44,000 binding sites/cell and 19,000 binding sites/cell, respectively. Bound 125I‐[Tyr4]‐bombesin was rapidly internalized by PC‐3 cells. The nonhydrolyzable GTP analog GTP‐gamma‐S caused a dose‐dependent inhibition of 125I‐[Tyr4]‐bombesin binding to PC‐3 and DU‐145 cells, indicating that a G‐protein (guanine nucleotide‐binding protein) couples the bombesin receptor to intracellular effector systems. Bombesin and GRP(14‐27) inhibited the binding of 125I‐[Tyr4]‐bombesin to both cell lines in a dose‐dependent manner with inhibition constants (Ki of 0.5 nM and 0.4 nM, respectively. Both cell lines express the bombesin/GRP preferring bombesin receptor subtype, since, in displacement studies, neuromedin B was more than 200 times less potent than bombesin and GRP(14‐27) in inhibiting the binding of 125I‐[Tyr4]‐bombesin. Two synthetic bombesin/GRP antagonists, RC‐3095 and RC‐3110, powerfully inhibited the specific binding of 125I‐[Tyr4]‐bombesin with Ki 0.92 nM and 0.26 nM on PC‐3 cells, and 3.3 nM and 0.89 nM on DU‐145 cells, respectively. These findings indicate that the PC‐3 and DU‐145 human prostate cancer cell lines possess specific high‐affinity receptors for bombesin/GRP, and are suitable models for the evaluation of the antineoplastic activity of new bombesin/GRP antagonists in the treatment of androgen‐independent prostate cancer. © 1994 Wiley‐Liss, Inc.
Detection Mechanism in SNSPD: Numerical Results of a Conceptually Simple, Yet Powerful Detection Model

In a recent publication we have proposed a numerical model that describes the detection process of optical photons in superconducting nanowire single-photon detectors (SNSPD). Here, we review this model and present a significant improvement that allows us to calculate more accurate current distributions for the inhomogeneous quasi-particle densities occurring after photon absorption. With this new algorithm we explore the detector response in standard NbN SNSPD for photons absorbed off-center and for 2-photon processes. We also discuss the outstanding performance of SNSPD based on WSi. Our numerical results indicate a different detection mechanism in WSi than in NbN or similar materials.
The validity of inferences based on incomplete observations in disease state models.

In many survival time studies or studies on the progression of a disease, information is often incomplete in the sense that it is known only that a patient has been in certain disease states at several time points. In this paper, conditions concerning the interrelationship between the disease process and the examination scheme (i.e., the pattern of examination times) are derived under which a valid statistical inference is possible. These conditions are confronted with examination schemes that are of practical importance in clinical research. A cancer marker study is used as an example to estimate the magnitude of the potential bias when the conditions derived are violated.