Miracle-dz/UniFAR-FTUs huggingface dataset:
Greater Neural Pattern Similarity Across Repetitions Is Associated with Better Memory

One, Two, Three, Remember Me When a stimulus (such as a word or a face) is presented for the second, third, or fourth time, do the neural representations differ? And, if they do, are multiply represented stimuli remembered better? These questions and related ones have fascinated psychologists for decades, but only recently has it become feasible to begin tackling them using neuroimaging. Xue et al. (p. 97, published online 9 September) provide evidence that the greater the similarity in the patterns of neural activity during encoding of the item, the greater the likelihood that the item will be remembered. Similarity in neural representations is associated with better memory, as well as conscious cognition. Repeated study improves memory, but the underlying neural mechanisms of this improvement are not well understood. Using functional magnetic resonance imaging and representational similarity analysis of brain activity, we found that, compared with forgotten items, subsequently remembered faces and words showed greater similarity in neural activation across multiple study in many brain regions, including (but not limited to) the regions whose mean activities were correlated with subsequent memory. This result addresses a longstanding debate in the study of memory by showing that successful episodic memory encoding occurs when the same neural representations are more precisely reactivated across study episodes, rather than when patterns of activation are more variable across time.
Risk Factors for Posterior Shoulder Instability in Young Athletes

Background: While posterior glenohumeral instability is becoming increasingly common among young athletes, little is known of the risk factors for injury. Purpose: To determine the modifiable and nonmodifiable risk factors for posterior shoulder instability in a high-risk cohort. Study Design: Case-control study (prognosis); Level of evidence, 2. Methods: A prospective cohort study in which 714 young athletes were followed from June 2006 through May 2010 was conducted. Baseline testing included a subjective history of instability, instability testing by a sports medicine fellowship–trained orthopaedic surgeon, range of motion, strength measurement with a handheld dynamometer, and bilateral noncontrast magnetic resonance imaging of the shoulder. A musculoskeletal radiologist measured glenoid version, height, depth, rotator interval (RI) height, RI width, RI area, and RI index. Participants were followed to document all acute posterior shoulder instability events during the 4-year follow-up period. The time to the posterior shoulder instability event during the follow-up period was the primary outcome of interest. Univariate and multivariable Cox proportional hazards regression models were used to analyze the data. Results: Complete data on 714 participants were obtained. During the 4-year surveillance period, 46 shoulders sustained documented glenohumeral instability events, of which only 7 were posterior in direction. The baseline factors that were associated with subsequent posterior instability during follow-up were increased glenoid retroversion (P < .0001), increased external rotation strength in adduction (P = .029) and at 45° of abduction (P = .015), and increased internal rotation strength in adduction (P = .038). Conclusion: This is the largest known prospective study to follow healthy participants in the development of posterior shoulder instability. Posterior instability represents 10% of all instability events. The most significant risk factor was increased glenoid retroversion. While increased internal/external strength was also associated with subsequent instability, it is unclear whether these strength differences are causative or reactive to the difference in glenoid anatomy. This work confirms that increased glenoid retroversion is a significant prospective risk factor for posterior instability.
The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes

Cells from some tumors use an altered metabolic pattern compared with that of normal differentiated adult cells in the body. Tumor cells take up much more glucose and mainly process it through aerobic glycolysis, producing large quantities of secreted lactate with a lower use of oxidative phosphorylation that would generate more adenosine triphosphate (ATP), water, and carbon dioxide. This is the Warburg effect, which provides substrates for cell growth and division and free energy (ATP) from enhanced glucose use. This metabolic switch places the emphasis on producing intermediates for cell growth and division, and it is regulated by both oncogenes and tumor suppressor genes in a number of key cancer-producing pathways. Blocking these metabolic pathways or restoring these altered pathways could lead to a new approach in cancer treatments.
Conditional Cooperation and Costly Monitoring Explain Success in Forest Commons Management

Pulling Together Human social norms can be explored in experiments that provide insights into the situational conditions and individual preferences that prompt the expression of cooperative behavior and the enforcement of norms. Rustagi et al. (p. 961; see the Perspective by Vollan and Ostrom) analyzed a set of 49 user groups, comprising 679 individuals, who had been given the authority and responsibility to manage forests in the Bale region of Ethiopia. The forests managed by groups with larger proportions of conditional cooperators—that is, individuals who will behave in a cooperative fashion if others do so as well—produced more potential crop trees per hectare. Enforcing such behavior, via patrolling of the forests, which although a costly and time-intensive activity, was the key to productivity Social behaviors in lab experiments that result in long-term productivity are seen in a real-world forest management program. Recent evidence suggests that prosocial behaviors like conditional cooperation and costly norm enforcement can stabilize large-scale cooperation for commons management. However, field evidence on the extent to which variation in these behaviors among actual commons users accounts for natural commons outcomes is altogether missing. Here, we combine experimental measures of conditional cooperation and survey measures on costly monitoring among 49 forest user groups in Ethiopia with measures of natural forest commons outcomes to show that (i) groups vary in conditional cooperator share, (ii) groups with larger conditional cooperator share are more successful in forest commons management, and (iii) costly monitoring is a key instrument with which conditional cooperators enforce cooperation. Our findings are consistent with models of gene-culture coevolution on human cooperation and provide external validity to laboratory experiments on social dilemmas.
Are Root Avulsions of the Lateral Meniscus Associated With Extrusion at the Time of Acute Anterior Cruciate Ligament Injury?

Background: Lateral meniscal avulsions left in situ at the time of anterior cruciate ligament (ACL) reconstruction do well subjectively. Limited published results measure meniscal extrusion of the lateral compartment in this setting. Purpose: To determine whether an avulsion of the posterior root of the lateral meniscus is associated with meniscal extrusion on magnetic resonance imaging (MRI). Study Design: Cohort study (prevalence); Level of evidence, 2. Methods: A prospective database of surgically treated ACL tears from 2007 to 2012 was reviewed. Isolated ACL tears without a concomitant injury were identified along with ACL tears in combination with lateral meniscal tears of the posterior root (PRLMTs). Thirty-five patients had ACL tears and PRLMTs verified arthroscopically, of which 23 patients had preoperative MRI scans available for review. From the same database, 25 isolated ACL tears with no meniscal injury were randomly chosen for comparison. Plain radiographs were reviewed for degenerative joint disease using the Kellgren-Lawrence scale. A board-certified radiologist blinded to arthroscopic findings reviewed each MRI scan using midcoronal sections to measure extrusion of the lateral meniscus. The average extrusion was calculated for each group and compared using a Student t test. Results: In the 48 patients reviewed, 1 patient was excluded because of a complex lateral meniscal tear that could not be measured on MRI. The remaining 47 consisted of 22 with root tears and 25 with intact menisci. None of these patients were noted to have degenerative joint disease greater than Kellgren-Lawrence grade 1. All of the patients with PRLMTs were noted to have intact meniscofemoral ligaments at the time of arthroscopic surgery. In the patients with ACL tears and PRLMTs, the average extrusion was 0.8 mm, and in the ACL tear group with an intact meniscus, the average extrusion measured 0.5 mm. No significant difference in the amount of extrusion was observed (P = .22). Conclusion: At the time of acute ACL injuries, PRLMTs do not appear to result in meniscal extrusion on MRI.
Hip and Glenohumeral Rotational Range of Motion in Healthy Professional Baseball Pitchers and Position Players

Background: Research suggests that limitations in the hip motion of baseball players may lead to altered motion at the glenohumeral joint to maintain throwing velocity, thereby predisposing the upper extremity to injury. Purpose: To measure and evaluate the correlation between hip and shoulder rotational range of motion (ROM) in healthy professional baseball players. Study Design: Descriptive laboratory study. Methods: Ninety-nine professional baseball players (50 pitchers and 49 position players; mean age ± standard deviation [SD], 22 ± 2.8 years; mean height ± SD, 187 ± 5.4 cm; mean weight ± SD, 81.6 ± 7.7 kg) with no history of hip or shoulder injury were tested. Dominant and nondominant hip and glenohumeral joints were measured for the following passive ROM variables: (1) hip internal rotation (IR), (2) hip external rotation (ER), (3) total hip rotational ROM (IR + ER), (4) isolated glenohumeral IR, (5) isolated glenohumeral ER, and (6) total glenohumeral rotational ROM (IR + ER). Results: Statistically, hip ER and total hip rotational ROM were greater in position players than in pitchers and less in the lead leg compared with the stance leg hip with groups combined; however, differences are not clinically meaningful. Pitchers had more glenohumeral rotational ROM than did position players. For all players, glenohumeral motion had less IR and greater ER in the throwing arm than the nonthrowing arm, but total glenohumeral rotational ROM was equivalent between sides. The correlations between hip and glenohumeral ROM were little, if any, and ranged from r = −0.19 to 0.11 (P = .006-.94) for all players and r = −0.29 to 0.23 (P = .04-.97) for pitchers only. Conclusion: These data suggest no clinically meaningful differences in hip ROM between pitchers and position players and between lead leg and stance legs of all players. There is little or no relationship between hip and glenohumeral ROM in healthy professional baseball players. Clinical Relevance: The study findings add to the growing body of evidence that suggests an absence of chronic hip ROM adaptations. It is therefore suggested that in the hip, unlike the glenohumeral joint, symmetry in ROM between player positions and dominant and nondominant sides should be expected in healthy professional baseball pitchers and position players.
Postoperative Imaging of Bioabsorbable Anchors in Rotator Cuff Repair

Background: Bioabsorbable anchors may lead to osteolysis and cyst formation. However, the prevalence of these outcomes is not known for rotator cuff repairs. Purpose: To evaluate cyst formation after placement of bioabsorbable anchors for rotator cuff repairs and to verify whether bioabsorbable anchors degraded as intended and preserved bone stock for possible revision compared with metal anchors. The null hypothesis was that the rate and severity of cyst formation around the anchor are negligible. Study Design: Case series; Level of evidence, 4. Methods: Between April 2008 and November 2011, a total of 209 patients (85 men, 124 women) underwent rotator cuff repair with bioabsorbable suture anchors (113 with polylactic acid enantiomers [PLLA] and 96 with poly-D,L-lactide from L-lactide and D-lactide [PLDLA]); the patients underwent magnetic resonance imaging (MRI) evaluation more than 10 months after surgery. The fluid signal around the anchor on T2-weighted MRI scans was graded as follows: grade 0, no fluid around anchor; grade 1, minimal fluid around anchor; grade 2, local fluid around anchor; grade 3, fluid collection around entire length of anchor with cyst diameter less than twice the anchor diameter; and grade 4, cyst diameter larger than grade 3. The integrity of repairs was also evaluated. Results: Cysts were observed in 97 instances (46.4%). There were 41 grade 1 cases (19.6%), 16 grade 2 (7.7%), 22 grade 3 (10.5%), and 18 grade 4 (8.6%). Healing of repaired tendon was observed in 131 patients (62.7%). There was no statistical difference in healing rate between patients with and without cyst formation (66.1% vs 58.8%; P = .276). Altered anchor shape and absorption were not observed in most of the patients. However, in 12 patients (6 with PLLA and 6 with PLDLA anchors), T2-weighted scans showed that the signal intensity of anchors had changed since surgery, which could indicate that absorption had taken place; nonetheless, even in these 12 patients, anchors were clearly visible on T1-weighted scans. Conclusion: Osteolysis and cyst formation are common complications following the use of bioabsorbable anchors in rotator cuff repairs. Considering that adequate absorption of anchors and preservation of bone stock are the reasons for using bioabsorbable anchors, use of these anchors should be reconsidered because of possible interference with revision surgery.
Hepatitis A: Past and Present

AV is a small, non-enveloped, and single-stranded RNA virus. The virus is transmitted from person to person through the fecal-oral route and through the ingestion of contaminated food. HAV infection normally affects children without producing symptoms but in adults it causes clinically apparent disease. The virus can spread easily from asymptomatic children to other children and to adult contacts. Children are thus considered to be a principal reservoir and dominant source of transmission in the community. Infection is maintained by serial transmission from infected individuals to those who are susceptible. While almost acute hepatitis A patients subside without progress to chronic liver disease, some patients may have relapsing, prolonged, cholestatic and fulminant hepatitis. Hepatitis A vaccine has been used successfully to prevent hepatitis A infection worldwide since mid-1990s. The sero-positivity pattern of anti-hepatitis A virus antibody (anti-HAV) has been changing rapidly from the intermediate to the low during the past 30 years in Korea. Thus adulthood acute hepatitis A became widespread in last 10 years in Korea due to decreased seroprevalence of anti-HAV. It can be recognized that acute hepatitis A is a “growing and living”, not a “fading and dying” disease. The changes in seroepidemiologic pattern may cause sporadic and large community outbreaks and lead to increased healthcare cost. In this situation, we should have our own vaccination strategy to prevent and future eradication of hepatitis A infection.
Species Selection Maintains Self-Incompatibility

Incompatible Self-Compatibility Macroevolutionary processes driving species differences in diversification rates are important in explaining the variation we see in nature, but the extent of this process and how much the traits within a single species can drive changes in the diversification rate are unknown. Goldberg et al. (p. 493; see the Perspective by Wright and Barrett) analyzed the phylogenetics of the plant family Solanaceae and found that rates of extinction are greater for self-pollinating species than outbreeding species. Species-level selection against the deleterious effects of inbreeding may explain why self-fertilization, despite its short-term evolutionary advantages, has not spread to become more common in the flowering plants. Self-incompatibility in a family of plants is associated with appreciably higher rates of speciation. Identifying traits that affect rates of speciation and extinction and, hence, explain differences in species diversity among clades is a major goal of evolutionary biology. Detecting such traits is especially difficult when they undergo frequent transitions between states. Self-incompatibility, the ability of hermaphrodites to enforce outcrossing, is frequently lost in flowering plants, enabling self-fertilization. We show, however, that in the nightshade plant family (Solanaceae), species with functional self-incompatibility diversify at a significantly higher rate than those without it. The apparent short-term advantages of potentially self-fertilizing individuals are therefore offset by strong species selection, which favors obligate outcrossing.
Amazonia Through Time: Andean Uplift, Climate Change, Landscape Evolution, and Biodiversity

The Making of Amazonian Diversity The biodiversity of the Amazon Basin is legendary, but the processes by which it has been generated have been debated. In the late 20th century the prevalent view was that the engine of diversity was repeated contraction and expansion of forest refugia during the past 3 million years or so. Hoorn et al. (p. 927) analyze findings from a diverse range of disciplines, including molecular phylogeny, ecology, sedimentology, structural geology, and palaeontology, to offer an overview of the entire history of this region during the Cenozoic era (66 million years ago). The uplift of the Andes was a pivotal event in the evolution of Amazonian landscapes because it continually altered river drainage patterns, which in turn put a variety of pressures on organisms to adapt to changing conditions in a multiplicity of ways. Hence, the diversity of the modern biota of the Amazon has more ancient origins than previously thought. The Amazonian rainforest is arguably the most species-rich terrestrial ecosystem in the world, yet the timing of the origin and evolutionary causes of this diversity are a matter of debate. We review the geologic and phylogenetic evidence from Amazonia and compare it with uplift records from the Andes. This uplift and its effect on regional climate fundamentally changed the Amazonian landscape by reconfiguring drainage patterns and creating a vast influx of sediments into the basin. On this “Andean” substrate, a region-wide edaphic mosaic developed that became extremely rich in species, particularly in Western Amazonia. We show that Andean uplift was crucial for the evolution of Amazonian landscapes and ecosystems, and that current biodiversity patterns are rooted deep in the pre-Quaternary.
A novel system for expansion and delivery of human keratinocytes for the treatment of severe cutaneous injuries using microcarriers and compressed collagen

Cell therapy with autologous or allogeneic keratinocytes applied as a single‐cell suspension is well established in clinical practice in the treatment of severe burn injuries to augment epithelial barrier restoration. Yet, the application of cell sprays can lead to significant cell loss owing to lack of adhesion of cell suspension to the wound bed. The development of a robust and controllable method of transplanting cells onto the wound bed is yet to be established. The ability to control adhesion and distribution of cells by using a cell carrier embedded in a biodegradable scaffold could significantly improve the treatment of cutaneous wounds with keratinocyte cell therapy. Several microcarrier‐based systems for expanding keratinocytes already exist. A new method for expansion of human keratinocytes in a feeder‐free, defined medium system on microcarriers has been developed. The cells retained their basal, proliferative phenotype after rapid expansion in a clinically relevant time‐frame. The cell‐laden microcarriers were further incorporated into collagen scaffolds fabricated by plastic compression. When cultured in vitro, cells continued to proliferate and migrate along the surface of the collagen scaffold. Using an in vitro wound bed model, cells were observed to form mostly single cell layers and in some areas multiple cell layers within 8 days, while retaining their basal, proliferative phenotype, indicating the suitability of this cell transplantation method to improve epithelial barrier restoration. This advanced cell expansion and delivery method for cutaneous cell therapy provides a flexible tool for use in clinical application. Copyright © 2017 John Wiley & Sons, Ltd.
Contribution of a Muscle Fatigue Protocol to a Dynamic Stability Screening Test for Exertional Medial Tibial Pain

Background: Enhancing the accuracy of a risk factor screening test is an important element of sports injury prevention. Purpose: To determine the effect of muscle fatigue on a screening tool for those at risk of exertional medial tibial pain (EMTP). Study Design: Cohort study (prognosis); Level of evidence, 2. Methods: Sixty-nine female students in a physical education program with a mean age of 19.24 ± 0.86 years were tested at the beginning of their first academic year and followed for 1 to 2 years. Participants completed an online questionnaire every week and a retrospective control questionnaire every 3 months, which were used to assess injury follow-up. A diagnosis of EMTP was made by an experienced medical doctor. A Cox regression analysis was used to identify the potential risk factors by comparing prefatigue and postfatigue data between uninjured participants and those with EMTP. Both the leg that developed EMTP and the contralateral leg were compared with legs of a matched control group. Results: During injury follow-up, 21 female participants were diagnosed with EMTP. Results of the comparison between uninjured versus EMTP participants, respectively, are as follows: For the leg at risk in the nonfatigued state, only increased range of motion in the transverse plane (ROMT) of the hip during landing could be identified as a risk factor (8.44° ± 2.94° vs 11.69° ± 3.41°; P = .002). In the fatigued state, increased ROMT of the hip and pelvis during landing (hip: 8.04° ± 2.34° vs 9.36° ± 3.22°; P = .038; pelvis: 6.99° ± 2.20° vs 8.58° ± 3.13°; P = .040) and increased ROMT of the thorax during pushoff (8.83° ± 2.74° vs 10.69° ± 3.20°; P = .036) could be identified. For the leg not at risk for EMTP, increased ROMT of the knee during landing (10.96° ± 3.12° vs 14.07° ± 4.88°; P = .023) and decreased ROMT of the pelvis during pushoff (8.16° ± 3.48° vs 6.47° ± 2.47°; P = .034) were identified in the nonfatigued state but were not significant in the fatigued state. Conclusion: Adding a muscle fatigue protocol to the single-legged drop jump as a screening test for EMTP risk factors may enhance the possibility of identifying the leg at risk in a predisposed athlete and might determine the proximal risk factors for that leg at risk more thoroughly.