Miracle-dz/UniFAR-FTUs huggingface dataset:
Transgender community resilience on YouTube: Constructing an informational, emotional, and sociorelational support exchange

Abstract This strength‐based, mixed‐methods study explored how trans individuals utilize transvlogs as a community building and resilience resource. Eighty‐six transvlog viewers explained their motivation for viewing transvlogs and additionally rated their self‐efficacy and well‐being. Narrative analyses indicate that participants viewed transvlogs to gain informational, emotional, and sociorelational resources. Twelve percent of participants additionally shared those resources with others and contributed to a relational resilience exchange. In addition, transvlog viewers' self‐efficacy and well‐being scores were higher than previously reported means. While prior research has noted the benefits of transvlog creation, the present study furthers this study by suggesting that transvlog viewers interactionally benefit as well. Participants in this study were not passive viewers, but rather active, agentive contributors to a trans community resilience exchange. Building on this study, we conclude with a discussion of how therapists can incorporate extant trans‐created resources to foster trans community resilience.
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

Histone deacetylases (HDACs) play important roles in transcriptional regulation and pathogenesis of cancer. Thus, HDAC inhibitors are candidate drugs for differentiation therapy of cancer. Here, we show that the well‐tolerated antiepileptic drug valproic acid is a powerful HDAC inhibitor. Valproic acid relieves HDAC‐dependent transcriptional repression and causes hyperacetylation of histones in cultured cells and in vivo. Valproic acid inhibits HDAC activity in vitro, most probably by binding to the catalytic center of HDACs. Most importantly, valproic acid induces differentiation of carcinoma cells, transformed hematopoietic progenitor cells and leukemic blasts from acute myeloid leukemia patients. More over, tumor growth and metastasis formation are significantly reduced in animal experiments. Therefore, valproic acid might serve as an effective drug for cancer therapy.
Magnet arrangement of linear PM vernier machine

We proposed a linear vernier machine with permanent magnets on armature side only. In this machine, the armature winding and permanent magnets are located on the mover; therefore, the stator is composed only of an iron core with small teeth. This feature contributes greatly to low-cost linear machine system for long distance application. However, higher force densities will likely be required to improve the scope of this machine's applicability. For this reason, we investigated the permanent magnet arrangement and achieved an improvement in the force density of 68% in evaluations through the finite element analysis. This paper presents the details of the investigations.
Temporal Discrimination in Pigeons

Pigeons trained to peck a lighted key were presented with a key that was alternately dark and lighted. The key was dark for intervals of from 3 to 30 seconds. Pecking of the lighted key was reinforced only after the shortest or, in a second experiment, the longest interval that the key was dark. The pigeons were able to discriminate the duration of the dark interval.
Heritability and repeatability of speed for 2- and 3-year-old standardbred racehorses.

Repeatabilities (t) and heritabilities (h2) of racing time were estimated from data on 7,206 2- and 3-yr-old Standardbred pacers and trotters competing in 1-mile (1.6 km) charted races at six tracks between 1975 and 1978. A total of 38,487 records representing 2,387 sire progeny groups were divided into subsets by gait, age and track. Initially, the designation "class of race" was recognized as a subjective categorization that reflected nonrandom assignments of horses to races. After extensive investigation, we concluded that racing times should be adjusted by linear regression for the time of the winning horse (defined at the "pace" of the race). Residual regression coefficients of time on pace ranged from . 61 +/- . 08 to . 79 +/- . 05 s/s and appeared to adequately account for the environmental effects of class. Repeatabilities of adjusted times ranged from . 32 +/- . 08 to . 55 +/- . 04 and heritabilities ranged from -. 25 +/- . 22 to . 66 +/- . 16. Overall estimates of t and h2 (pooled over gaits, ages and tracks) were . 44 +/- . 01 and . 29 +/- . 03, respectively. When data were not adjusted for pace, the sire, horse and error variance component estimates were inflated by environmental effects (pooled t = .62; pooled h2 = .36). Racing time adjusted for pace is recommended for use as a selection criterion in Standardbred horses.
KNOWLEDGE AND PRACTICE REGARDING ORAL REHYDRATION THERAPY FOR ACUTE DIARRHOEA AMONG MOTHERS OF UNDER-FIVE CHILDREN IN AN URBAN AREA OF PUDUCHERRY, INDIA

Background: Diarrhoea is a major cause of morbidity and mortality among under-five children. Correct knowledge regarding Oral Rehydration Therapy (ORT) helps prevent morbidity and mortality due to diarrhoea. Our objective was to assess the awareness, knowledge and practice of mothers of under-five children regarding ORT and home management of diarrhoea. Methods: A cross-sectional study was carried out during September 2012. A structured and pre-tested questionnaire was administered to all the mothers of under-five children in the study area. Results: A total of 252 children and 245 mothers were covered. Around two-thirds of mothers knew about at least one method of diarrhoea prevention. Three-fourths of mothers had heard of Oral Rehydration Solution (ORS) and knew how to prepare and administer ORS. Also, majority of mothers (82.9%) were aware about home available fluids for rehydration. Around half of the mothers who knew about ORS thought that ORS had to be discontinued if diarrhoea persisted or vomiting developed. Mothers educated only till class eight were almost twice less likely to know about ORS preparation as compared to better educated mothers (OR = 2.15, 95% CI 1.14 – 4.05, P = 0.02). No association was found between lack of knowledge regarding home available fluids with younger age, low education of mothers or low per capita income. Conclusion: Although awareness regarding ORS and home available fluids was adequate, knowledge regarding its continuation in persistent diarrhoea or vomiting was poor. Lack of education predisposed to ignorance regarding ORS preparation.
Results of a survey of attitudes of dairy veterinarians in New Zealand regarding painful procedures and conditions in cattle

Abstract AIMS: To quantify the range of attitudes and perceptions of cattle practitioners to painful procedures and conditions in cattle, to identify some of the demographic factors affecting those attitudes and perceptions, and to compare results from veterinarians based in New Zealand with those from the United Kingdom (UK) and Europe. METHODS: A questionnaire, based on one used for similar surveys in Europe, was sent to all 455 members of the Society of Dairy Cattle Veterinarians (DCV) of the New Zealand Veterinary Association. This questionnaire included a section on demographic data, e.g. gender, year of graduation, and preveterinary school background, and a section which asked the respondents to rate on a scale of 1 to 10 how painful they thought 24 procedures and conditions would be without any analgesia. RESULTS: A total of 166 questionnaires were returned, a response rate of 37%. From the range of procedures and conditions outlined in the questionnaire, those perceived as most painful were claw amputation, then Caesarean section, followed by surgery for left-displaced abomasum (LDA). The two least painful were mastitis with milk clots only, and the effect on a calf of dystocia. There were significant differences between the pain scores assigned by men and women and by respondents who had graduated in different decades. Female respondents and more recent graduates tended to give a higher pain score for most conditions. These effects remained, even after the potential interaction between age and gender had been assessed. The effect on pain score of either background or time spent treating cattle was much less marked than the effect of age and gender. Overall, the results were very similar to results from similar surveys undertaken in the UK and Europe. CONCLUSIONS: The responses to this survey indicate that, as in the UK and Europe, dairy cattle practitioners in New Zealand have a wide range of attitudes to pain in cattle. The estimates of the severity of pain were subjective, but such a survey allows the majority opinion of a considerable number of informed assessors to be quantified. CLINCAL RELEVANCE: The wide range of results suggests that more needs to be done to disseminate up-to-date knowl- edge of pain in cattle to veterinarians to ensure they provide appropriate levels of analgesia. In particular, the baseline data from this study can be used by practitioners to identify whether they are underestimating pain in cattle and, if they are, to assess whether they are using analgesia appropriately. Additionally, this dataset provides an informed and independent assessment of the pain associated with husbandry procedures, and could be used to better guide legislation concerning pain control of such procedures.
Accuracy of Proximal Caries Depth Measurements: Comparison between Limited Cone Beam Computed Tomography, Storage Phosphor and Film Radiography

The aim of this study was to compare the accuracy of limited cone beam computed tomography (LCBCT), an image plate system and F-speed film in assessing the depth of proximal carious lesions. Radiographs of a dry mandible with sound and carious teeth were obtained with all three methods. In 41 molar and premolar proximal surfaces, 2 observers independently measured lesion depth on the images from the three modalities. The correlation of measurements was assessed with Pearson’s correlation analysis. Results from imaging modalities and histological sectioning (gold standard) were compared using Bland-Altman plots. Overall comparison of the depth measurements from the imaging modalities and the gold standard was done using repeated-measures ANOVA. Pairwise comparisons of systems were done by the Bonferroni t test. The correlation between the measurements of the two observers was 0.977 for film, 0.997 for image plate system and 0.998 for LCBCT. Bland-Altman plots revealed that LCBCT agreed very closely with the gold standard while the agreement between the latter and the image plate – or film – images was moderate. The mean difference and 95% limits of agreement between LCBCT and the gold standard were smaller than those between either image plate or F-speed film and the gold standard. The LCBCT method appears as a promising tool for detection and monitoring of proximal carious lesions.
Enhancing Sequential Time Perception and Storytelling Ability of Deaf and Hard of Hearing Children

A 3-month intervention was conducted to enhance the sequential time perception and storytelling ability of young children with hearing loss. The children were trained to arrange pictorial episodes of temporal scripts and tell the stories they created. Participants (N = 34, aged 4-7 years) were divided into 2 groups based on whether their spoken-language gap was more or less than 1 year compared to age norms. They completed A. Kaufman and N. Kaufman's (1983) picture series subtest and Guralnik's (1982) storytelling test at pretest and posttest. Measures demonstrated significant improvement in sequential time and storytelling achievement postintervention. Three of the examined demographic variables revealed correlations: Participants with genetic etiology showed greater improvement in time sequencing and storytelling than participants with unknown etiology; early onset of treatment correlated with better achievement in time sequencing; cochlear implant users showed greater storytelling improvement than hearing aid users.
Serologically HLA-DR—Mismatched Unrelated Donors Might Provide a Valuable Alternative in Allogeneic Transplantation: Experience from a Single Japanese Institution

To clarify the clinical significance of a serologic HLA-DR mismatch after unrelated-donor transplantation, we evaluated for hematologic malignancies 123 cases of unrelated bone marrow transplantation carried out in a single institution between 1995 and 2004. Of the patients in these cases, 12 were serologically mismatched at the single HLA-DR locus. Eighty-two patients who received HLA-matched transplantations were used as controls. Conditioning consisted of a conventional total body irradiation —based regimen or a fludarabine-based reduced-intensity regimen. Prophylaxis for graft-versus-host disease (GVHD) consisted of tacrolimus plus short-term methotrexate. Graft failure did not develop. With a median follow-up of 42 months (range, 11-99 months), rates of overall survival, nonrelapse mortality, and relapse at 4 years were 63%, 38%, and 0%, respectively, all of which were comparable with those after HLA-matched transplantation. The frequency of acute GVHD of grades II to IV was 75%, significantly higher than after HLA-matched transplantation (42%, P = .046), and there was a trend toward an increased incidence of acute GVHD of grades III to IV after serologically HLA-DR —mismatched unrelated transplantation (27% versus 10%, P = .093). Chronic GVHD developed in 4 of 11 evaluable patients, an incidence comparable with that after HLA-matched transplantation. In summary, serologically HLA-DR —mismatched unrelated transplantation is feasible and might be an acceptable alternative for the Japanese population, although the higher incidence of acute GVHD is notable.
CORONARY HEART DISEASE IN SEVEN RACIAL GROUPS IN SINGAPORE

The purpose of this communication is to examine the pattern of coronary heart disease over the years 1948 to 1957 inclusive, as seen in the mortuary of the General Hospital at Singapore in 19,415 consecutive autopsies, and to determine whether there are racial differences. The macroscopic data considered relevant were transferred from the post-mortem protocols on to a specially prepared proforma in all those cases in which the principal cause of death was given as coronary heart disease. The series does not include other cases in which coronary heart disease was an incidental finding. The Island of Singapore and its Population. Singapore, an island of some 217 square miles, lies one degree north of the Equator and 104 degrees east of Greenwich. The climate is equable, the average temperature being 850 F. and the average relative humidity 83 per cent. There are no seasons. On the Island live some one and a half million people of varying races, religions, customs, and dietary habits. When Thomas Stamford Raffles landed on the Island in 1819 the population was in the region of 150, all Bugis Malay. In 1824 when the Island was formally ceded to the East India Company, it had risen to 10,000. Free immigration continued, mainly from China and India, until about 1939. Since then the polyglot populace has rapidly increased until it has reached the figures shown in Table I.
Concise Review: Roles of Polycomb Group Proteins in Development and Disease: A Stem Cell Perspective

The acquisition and maintenance of cell fate are essential for metazoan growth and development. A strict coordination between genetic and epigenetic programs regulates cell fate determination and maintenance. Polycomb group (PcG) genes are identified as essential in these epigenetic developmental processes. These genes encode components of multimeric transcriptional repressor complexes that are crucial in maintaining cell fate. PcG proteins have also been shown to play a central role in stem cell maintenance and lineage specification. PcG proteins, together with a battery of components including sequence‐specific DNA binding/accessory factors, chromatin remodeling factors, signaling pathway intermediates, noncoding small RNAs, and RNA interference machinery, generally define a dynamic cellular identity through tight regulation of specific gene expression patterns. Epigenetic modification of chromatin structure that results in expression silencing of specific genes is now emerging as an important molecular mechanism in this process. In embryonic stem (ES) cells and adult stem cells, such specific genes represent those associated with differentiation and development, and silencing of these genes in a PcG protein‐dependent manner confers stemness. ES cells also contain novel chromatin motifs enriched in epigenetic modifications associated with both activation and repression of genes, suggesting that certain genes are poised for activation or repression. Interestingly, these chromatin domains are highly coincident with the promoters of developmental regulators, which are also found to be occupied by PcG proteins. The epigenetic integrity is compromised, however, by mutations or other alterations that affect the function of PcG proteins in stem cells leading to aberrant cell proliferation and tissue transformation, a hallmark of cancer.
Association between Short Maternal Height and Low Birth Weight: a Hospital-based Study in Japan

Anthropometry measurements, such as height and weight, have recently been used to predict poorer birth outcomes. However, the relationship between maternal height and birth outcomes remains unclear. We examined the effect of shorter maternal height on low birth weight (LBW) among 17,150 pairs of Japanese mothers and newborns. Data for this analysis were collected from newborns who were delivered at a large hospital in Japan. Maternal height was the exposure variable, and LBW and admission to the neonatal intensive care unit were the outcome variables. Logistic regression models were used to estimate the associations. The shortest maternal height quartile (131.0–151.9 cm) was related to LBW (OR 1.91 [95% CI 1.64, 2.22]). The groups with the second (152.0–157.9 cm) and the third shortest maternal height quartiles (158.0–160.9 cm) were also related to LBW. A P trend with one quartile change also showed a significant relationship. The relationship between maternal height and NICU admission disappeared when the statistical model was adjusted for LBW. A newborn’s small size was one factor in the relationship between shorter maternal height and NICU admission. In developed countries, shorter mothers provide a useful prenatal target to anticipate and plan for LBW newborns and NICU admission.
Samian Pottery in Britain: Exploring its Distribution and Archaeological Potential

This paper presents some of the results of an English Heritage funded study of the distribution of samian pottery (Terra Sigillata). It aims to highlight the value of samian pottery as a resource for exploring a range of archaeological questions beyond its essential role in providing dating evidence. The work to date has comprised a pilot study designed to assemble an initial database of stratified samian groups, to test methodologies and to explore the character of samian distribution. Some substantive patterns identified from the database are reproduced here and discussed. The opportunity is also taken to clarify baseline trends in the occurrence of samian within Roman pottery assemblages, and to place patterns in the incidence of this ware within the wider context of Roman Britain. A number of other aspects of archaeological value, for instance, the nature of samian from rural sites and the potential use of samian in ritual actions, are also evaluated. A written report and (hardcopy) database were prod.
Discrimination of selected species of pathogenic bacteria using near-infrared Raman spectroscopy and principal components analysis

Abstract. A method, based on Raman spectroscopy, for identification of different microorganisms involved in bacterial urinary tract infections has been proposed. Spectra were collected from different bacterial colonies (Gram-negative: Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa and Enterobacter cloacae, and Gram-positive: Staphylococcus aureus and Enterococcus spp.), grown on culture medium (agar), using a Raman spectrometer with a fiber Raman probe (830 nm). Colonies were scraped from the agar surface and placed on an aluminum foil for Raman measurements. After preprocessing, spectra were submitted to a principal component analysis and Mahalanobis distance (PCA/MD) discrimination algorithm. We found that the mean Raman spectra of different bacterial species show similar bands, and S. aureus was well characterized by strong bands related to carotenoids. PCA/MD could discriminate Gram-positive bacteria with sensitivity and specificity of 100% and Gram-negative bacteria with sensitivity ranging from 58 to 88% and specificity ranging from 87% to 99%.
Rythmes biologiques, fonctionnement vestibulaire et contrôle postural

L’objectif de ce travail est d’etudier l’effet de l’heure de la journee sur la fonction vestibulaire, le controle postural et la perception de la verticale chez des populations composees de sujets jeunes et de sujets âges. Afin de repondre a cet objectif, 2 etudes ont ete successivement conduites. La procedure experimentale a ete la meme pour les deux populations. Un protocole experimental dit « discontinu » compose de 6 sessions de tests a 02:00, 06:00, 10:00, 14:00, 18:00 et 22:00h a ete mis en place. Chaque session de tests consistait en une evaluation (i) de la temperature, (ii) de la fatigue et de la somnolence subjectives (iii) du reflexe vestibulo-oculaire (iv) du controle postural et (v) de la perception de la verticale. Les resultats permettent de mettre en evidence des rythmes circadiens de la temperature, de la fatigue et de la somnolence avec des etats degrades lors des sessions de tests nocturnes. De la meme facon, des effets de l’heure de la journee sont observes sur le reflexe-vestibulo-oculaire avec une duree de mise en jeu plus longue le matin a laquelle s’ajoute une alteration de la vitesse du reflexe chez les sujets âges. En revanche, les resultats obtenus lors de l’evaluation du controle postural divergent entre nos deux populations. Les sujets jeunes ne presentent pas de rythme circadien du controle postural ce qui les eloigne de tous dangers de desequilibre ou de chute malgre une perception de la verticale degradee. Les sujets âges ont des capacites d’equilibration qui fluctuent au cours de la journee avec des performances degradees en fin de journee-debut de soiree, ce qui pourrait conduire a un risque de chute plus important durant cette periode.
Enhanced-Boost Z-Source Inverters With Switched Z-Impedance

This paper proposes a new topology for an enhanced-boost Z-source inverter (ZSI) with combined two Z-impedance networks. By two Z-impedance networks and low shoot-through duty cycle, the proposed inverter produces high output voltage gain. In traditional ZSIs for high boosting voltage, a low modulation index is required; hence, under these conditions, the output voltage will have low quality with high total harmonic distortion. Compared with the conventional high-boost ZSI topologies, the proposed inverter uses shorter shoot-through duration and a larger modulation index to improve the output waveform quality. Comparison between the proposed topology and previously proposed schemes, in terms of inductor numbers, voltage and current stresses on elements, sizes of inductors and capacitors, efficiency, and switching device product (SDP) factors of diodes, is made, and the results verify the priority of the proposed topology. The operating principle of the proposed topology is analyzed in detail. Both simulation and experimental results verify the high performance of the proposed inverter.