Miracle-dz/UniFAR-FTUs huggingface dataset:
A new multimedia packet loss classification algorithm for congestion control over wired/wireless channels

In a wireless network environment, common channel errors, due to multipath fading, shadowing and attenuation, may cause bit errors and packet loss quite different from the packet loss caused by network congestion. In congestion control, the packet loss information can serve as an index of network congestion for effective rate adjustment; therefore, wireless packet loss can mistakenly lead to dramatic performance degradation. The paper proposes a packet loss classification algorithm based on detecting the trend in relative one-way trip time (ROTT) when it falls in the ambiguous zone where the packet loss classification is not straightforward. We show that the proposed algorithm greatly benefits rate-based congestion control algorithms for multimedia over IP networks.
Severe intraoperative complications during VATS Lobectomy compared with thoracotomy lobectomy for early stage non-small cell lung cancer.

BACKGROUND Video-assisted thoracic surgery (VATS) lobectomy has been proved to have shorter hospital stay, less perioperative complications and less pain compared with lobectomy by thoracotomy, but severe intraoperative complications during VATS lobectomy is rare reported. We compared intraoperative safety between VATS lobectomy and lobectomy by thoracotomy. METHODS 659 patients with postoperative stage I and IIa non-small cell lung cancer (NSCLC) who underwent lobectomy in China-Japan Friendship Hospital from February 2008 to June 2012 were analyzed retrospectively, in which 277 were performed by thoracotomy, 357 performed by VATS, and 25 performed by VATS converted to open. Outcomes were analyzed to compare the incidence of significant bleeding, with conversion cases were included into VATS group. RESULTS Ten severe intraoperative complications were identified in 10 patients (6 in VATS, 4 in open), with no intraoperative deaths. The incidence of severe intraoperative complications was similar between VATS group and thoracotomy group [1.57% (6/382) vs. 1.44% (4/277), P=1.0]. Most severe intraoperative complications were related to the injury of major pulmonary vessels (9/10), and most of these complications occurred during upper lobectomy (8/10). There was no statistically significant difference in blood loss (242.85±220.47 vs. 240.43±144.36, P=0.865), and operative time (198.00±75.24 vs. 208.05±61.97, P=0.061) between the open and VATS groups, respectively, but blood loss and operative time are significant different after elimination of conversion cases (214.34±151.85 vs. 240.43±144.36, P<0.01; 193.24±72.64 vs. 208.05±61.97, P<0.01). CONCLUSIONS Our preliminary study demonstrated that the incidence of severe intraoperative complication during VATS lobectomy was low and similar to open lobectomy. The severe intraoperative complications during VATS lobectomy are manageable and the surgeons need to take proper caution in performing VATS lobectomy.
What Came First

A solution to get the problem off, have you found it? Really? What kind of solution do you resolve the problem? From what sources? Well, there are so many questions that we utter every day. No matter how you will get the solution, it will mean better. You can take the reference from some books. And the what came first is one book that we really recommend you to read, to get more solutions in solving this problem.
A foveated silicon retina for two-dimensional tracking

A silicon retina chip with a central foveal region for smooth-pursuit tracking and a peripheral region for saccadic target acquisition is presented. The foveal region contains a 9/spl times/9 dense array of large dynamic range photoreceptors and edge detectors. Two-dimensional direction of foveal motion is computed outside the imaging array. The peripheral region contains a sparse array of 19/spl times/17 similar, but larger, photoreceptors with in-pixel edge and temporal on-set detection. The coordinates of moving or flashing targets are computed with two one-dimensional centroid localization circuits located on the outskirts of the peripheral region. The chip is operational for ambient intensities ranging over six orders of magnitude, targets contrast as low as 10%, foveal speed ranging from 1.5 to 10 K pixels/s, and peripheral ON-set frequencies from <0.1 to 800 kHz. The chip is implemented in a 2 /spl mu/m n-well CMOS process and consumes 15 mW (Vdd=4 V) in normal indoor light (25 /spl mu/W/cm/sup 2/). It has been used as a person tracker in a smart surveillance system and a road follower in an autonomous navigation system.
Oxaliplatin for the treatment of ovarian cancer

Introduction: Oxaliplatin is an important drug in treatment of several solid tumors. Ovarian cancer (OC) is sensitive to chemotherapy and the overall response rate with primary therapy is about 75%. Unfortunately, 60 – 70% of patients experience recurrence requiring additional treatments and finally die of progressive disease within 5 years of the initial diagnosis. Currently, a platinum-based combination therapy is recommended in platinum-sensitive disease while a non-platinum single-agent therapy is preferred in platinum-resistant disease that is characterized by a low response rate. Areas covered: In this article, the authors review the Phase II and Phase III studies of oxaliplatin as an OC therapy. Furthermore, the authors discuss the pharmacokinetic and pharmacodynamic features of oxaliplatin. Expert opinion: Platinum emerged as the mainstay of OC treatment in frontline therapy, and platinum compounds remain a critical component of chemotherapy also in relapsed disease. Unfortunately, increasing exposure to carboplatin/cisplatin raises the risk of resistance or hypersensitivity to platinum. Several studies have demonstrated the safety and effectiveness of oxaliplatin, both alone and in combination regimens, in relapsed OC, demonstrating a good tolerability profile. Moreover, the therapeutic spectrum of oxaliplatin might be extended to OC patients who experienced hypersensitivity to carboplatin because of its favorable toxicity profile and at least equal efficacy.
Human retinal microglia express candidate receptors for HIV-1 infection

Background/aims: Microglia are the primary antigen presenting cells in the central nervous system and the retina, and can harbour viral antigens that may damage neural tissue via the release of neurotoxins. All cells bearing CD4 molecules and co-receptors (members of the chemokine receptor and Fcγ receptor families) are potential targets for the human immunodeficiency virus (HIV). In this study, retinal microglia (in vitro and in situ) were investigated for the expression of candidate HIV-1 binding receptors. Methods: Cultured human retinal microglia and frozen sections of human retinas were used. Immunohistochemistry was used to investigate expression of cell surface receptors necessary for HIV-1 infection: CD4, CC chemokine receptor 5 (CCR5), and Fcγ receptors. Results: Human retinal microglia expressed detectable levels of CD4, CD16, CD64, and CCR5 in vitro and Fcγ receptor I (CD64) in situ. Conclusions: Human retinal microglia express several candidate receptors required for viral binding and as such may be a potential reservoir for HIV-1 infection.
Effect of changing patient mix on the performance of an intensive care unit severity-of-illness model: how to distinguish a general from a specialty intensive care unit.

OBJECTIVE To analyze the effects of patient mix diversity on performance of an intensive care unit (ICU) severity-of-illness model. DESIGN Multiple patient populations were created using computer simulations. A customized version of the Mortality Probability Model (MPM) II admission model was used to ascertain probabilities of hospital mortality. Performance of the model was assessed using discrimination (area under the receiver operating characteristic curve) and calibration (goodness-of-fit testing). SETTING Intensive care units. PATIENTS Data were collected from 4,224 ICU patients from two Massachusetts hospitals (Baystate Medical Center, Springfield, MA; University of Massachusetts Medical Center, Worcester, MA) and two New York hospitals (Albany Medical Center, Albany, NY; Ellis Hospital, Schenectady, NY). INTERVENTIONS Random samples were taken from a database. The percentage of patients with each model disease characteristic was varied by assigning weights (ranging from 0 to 10) to patients with a disease characteristic. Three simulations were run for each of 15 model variables at each of 16 weights, totaling 720 simulations. MEASUREMENTS AND MAIN RESULTS The area under the receiver operating characteristic curve and model fit were assessed in each random sample. Removing patients with a given disease characteristic did not affect discrimination or calibration. Increasing frequency of patients with each disease characteristic above the original frequency caused discrimination and calibration to deteriorate. Model fit was more robust to increases in less frequently occurring patient conditions. From the goodness-of-fit test, a critical percentage for each admission model variable was determined for each disease characteristic, defined as the percentage at which the average p value for the test over the three replications decreased to < . 10. CONCLUSIONS The concept of critical percentages is potentially clinically important. It might provide an easy first step in checking applicability of a given severity-of-illness model and in defining a general medical-surgical ICU. If the critical percentages are exceeded, as might occur in a highly specialized ICU, the model would not be accurate. Alternative modeling approaches might be to customize the model coefficients to the population for more accurate probabilities or to develop specialized models. The MPM approach remained robust for a large variation in patient mix factors.
Prediction of adverse events during intensive induction chemotherapy for acute myeloid leukemia or high‐grade myelodysplastic syndromes

Intensive chemotherapy for newly diagnosed acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) is associated with significant treatment‐related morbidity and mortality. Herein, we investigate how pretreatment characteristics relate to early adverse outcomes in such patients, studying 205 consecutive individuals receiving curative‐intent induction chemotherapy with cytarabine and an anthracycline (“7 + 3”; n = 175) or a “7 + 3”‐like regimen (n = 30). Among the entire cohort, baseline grade 4 neutropenia (i.e., absolute neutrophil count <500 cells/µL) was associated with development of fever (P = 0.04), documented infection (P < 0.0001), and bacteremia (P = 0.002) but not requirement for intensive care unit‐level care; after exclusion of the 30 patients who received “7 + 3”‐like induction, baseline grade 4 neutropenia remained associated with documented infection (P < 0.0001) and bacteremia (P = 0.0005). Among patients achieving a complete remission with the initial treatment cycle, grade 4 neutropenia was associated with delayed neutrophil count recovery (P < 0.0001). Low monocyte and lymphocyte counts at baseline were similarly associated with increased risk of documented infection or bacteremia. After adjustment for age, gender, disease type, cytogenetic/molecular risk, and performance status, the risk of fever, documented infection, or bacteremia was 1.87 (95% confidence interval: 1.04–3.34; P=0.04)‐fold, 4.95 (2.20–11.16; P<0.001)‐fold, and 3.14 (0.99–9.98; P=0.05)‐fold higher in patients with initial grade 4 neutropenia. Together, our studies identify severe baseline neutropenia as a risk factor for infection‐associated adverse events after induction chemotherapy and may provide the rationale for the risk‐adapted testing of myeloid growth factor support in this high‐risk AML/MDS patient subset. Am. J. Hematol. 89:423–428, 2014. © 2014 Wiley Periodicals, Inc.
Properties and Performance of Folded Hypercubes

A new hypercube-type structure, the folded hypercube (FHC), which is basically a standard hypercube with some extra links established between its nodes, is proposed and analyzed. The hardware overhead is almost 1/n, n being the dimensionality of the hypercube, which is negligible for large n. For this new design, optimal routing algorithms are developed and proven to be remarkably more efficient than those of the conventional n-cube. For one-to-one communication, each node can reach any other node in the network in at most (n/2) hops (each hop corresponds to the traversal of a single link), as opposed to n hops in the standard hypercube. One-to-all communication (broadcasting) can also be performed in only (n/2) steps, yielding a 50% improvement in broadcasting time over that of the standard hypercube. All routing algorithms are simple and easy to implement. Correctness proofs for the algorithms are given. For the proposed architecture, communication parameters such as average distance, message traffic density, and communication time delay are derived. In addition, some fault tolerance capabilities of this architecture are quantified and compared to those of the standard cube. It is shown that this structure offers substantial improvement over existing hypercube-type networks in terms of the above-mentioned network parameters. >
Metadata Development for Palm Leaf Manuscripts in Thailand

The main objective of this research is, to develop metadata scheme for the management of digitized PLMs to increase efficiency in the search, access, management and use. The research framework was based on Functional Requirements for Bibliographic Records (FRBR) model developed by International Federation of Library Associations and Institutions (IFLA), while the metadata development process was developed on the concept of Metadata Life Cycle Model (MLM). Thus, there were three main parts in this study: (1) analysis of the user needs and expectations with respect to the manuscripts, of the requirements for managing collections of palm leaf manuscripts, and of physical structure and content of palm leaf manuscripts; (2) development of a metadata schema based on the results of these analyses; and (3) implementation and evaluation of the final metadata schema. The prototype of PLM management system was developed to implement the PLMM to test and evaluate the usefulness of PLMM for access to PLM original copies and their content and for managing PLM digital collection. The finding suggests that the perception of the PLMM usefulness is relatively significant with users' experience with the PLM. Finally, the PLM metadata schema (PLMM) was developed for palm leaf manuscripts consisted of 76 properties (34 core elements and 42 element refinements) to describe all versions and formats of the PLM. It can support both user tasks in searching for the PLMs and the collection management tasks. PLMM can dominantly express and describe the special characteristics and content of Thai Palm Leaf Manuscripts.
Mechanical Conditioning Influences the Metabolic Response of Cell-Seeded Constructs

Injuries and degenerative diseases to load-bearing soft tissues are extremely common in hospital clinics and involve all ages of the population. Tissue engineering provides a major focus for developments within this area due to the relative failure of graft and prosthetic-based strategies. On implantation, such systems will be subjected to normal physiological forces. It is important, therefore, to understand the effects of mechanical conditioning of cells within repair systems to predict their response and ultimate success in vivo. In the current study two well-characterised model systems, involving dermal fibroblasts seeded onto silicone membranes and chondrocytes seeded in agarose constructs, have been used to study the effects of mechanical loading on cellular activity. The data presented demonstrate that both the tensile conditioning of fibroblasts in monolayer and the compressive loading of chondrocytes in three-dimensional agarose constructs produced distinct responses. In particular, the nature of the strain field associated with the tensile system is important in determining the ultimate cell response. Equally within the compressive system the influence of dynamic frequency was shown to be important. The other critical factors in determining response to both types of conditioning are associated with the age of the cell and its original location within the tissue.
Automated 2-D Cephalometric Analysis on X-ray Images by a Model-Based Approach

Craniofacial landmark localization and anatomical structure tracing on cephalograms are two important ways to obtain the cephalometric analysis. In order to computerize them in parallel, a model-based approach is proposed to locate 262 craniofacial feature points, including 90 landmarks and 172 auxiliary points. In model training, 12 landmarks are selected as reference points and used to divide every training shape to 10 regions according to the anatomical knowledge; principle components analysis is employed to characterize the region shape variations and the statistical grey profile of every feature point. Locating feature points on an input image is a two-stage procedure. First, we identify the reference landmarks by image processing and pattern matching techniques, so that the shape partition is performed on the input image. Then, for each region, its feature points are located by a modified active shape model. All craniofacial anatomical structures can be traced out by connecting the located points with subdivision curves according to the prior knowledge. Users are permitted to modify the results interactively in many different ways. Experimental results show the advantage and reliability of the proposed method
A survey on energy estimation and power modeling schemes for smartphone applications

In the last decade, the rising trend in the popularity of smartphones motivated software developers to increase application functionality. However, increasing application functionality demands extra power budget that as a result, decreases smartphone battery lifetime. Optimizing energy critical sections of an application creates an opportunity to increase battery lifetime. Smartphone application energy estimation helps investigate energy consumption behavior of an application at diversified granularity (eg, coarse and fine granular) for optimal battery resource use. This study explores energy estimation and modeling schemes to highlight their advantages and shortcomings. It classifies existing smartphone application energy estimation and modeling schemes into 2 categories, ie, code analysis and mobile components power model–based estimation owing to their architectural designs. Moreover, it further classifies code analysis–based modeling and estimation schemes in simulation‐based and profiling‐based categories. It compares existing energy estimation and modeling schemes based on a set of parameters common in most literature to highlight the commonalities and differences among reported literature. Existing application energy estimation schemes are low‐accurate, resource expensive, or non‐scalable, as they consider marginally accurate smart battery's voltage/current sensors, low‐rate power capturing tools, and labor‐driven lab‐setting environment to propose power models for smartphone application energy estimation. Besides, the energy estimation overhead of the components power model–based estimation schemes is very high as they physically run the application on a smartphone for energy profiling. To optimize smartphone application energy estimation, we have highlighted several research issues to help researchers of this domain to understand the problem clearly.
Exome Sequencing Identifies a Novel FOXP3 Mutation in a 2-Generation Family With Inflammatory Bowel Disease

Objectives: Inflammatory bowel disease (IBD) is heritable, but a total of 163 variants commonly implicated in IBD pathogenesis account for only 25% of the heritability. Rare, highly penetrant genetic variants may also explain mendelian forms of IBD and some of the missing heritability. To test the hypothesis that rare loss-of-function mutations can be causative, we performed whole exome sequencing (WES) on 5 members of a 2-generation family of European ancestry presenting with an early-onset and atypical form of IBD. Methods: WES was performed for all of the 5 family members; the mother and 3 male offspring were affected, whereas the father was unaffected. Mapping, annotation, and filtering criteria were used to reduce candidate variants. For functional testing we performed forkhead box P3 (FOXP3) staining and a T-cell suppression assay. Results: We identified a novel missense variant in exon 6 of the X-linked FOXP3 gene. The c.694A>C substitution in FOXP3 results in a cysteine-to-glycine change at the protein position 232 that is completely conserved among all vertebrates. This variant (heterozygous in the mother and hemizygous in all 3 affected sons) did not impair FOXP3 protein expression, but significantly reduced the ability of the host's T regulatory cells to suppress an inappropriate autoimmune response. The variant results in a milder immune dysregulation, polyendocrinopathy, enteropathy, and X-linked phenotype with early-onset IBD. Conclusions: Our study illustrates the successful application of WES for making a definitive molecular diagnosis in a case of multiply affected families, with atypical IBD-like phenotype. Our results also have important implications for disease biology and disease-directed therapeutic development.
Gender and Alcoholic Subtypes

Although women generally have been subjects of alcohol research less often than men, gender can be used as a defining characteristic in subtyping schemes. Whether the sexes actually differ in aspects of their alcoholism, such as in etiology and degree of severity, however, is not known. Analyzing a sample of male and female alcoholics using several different statistical methods, the researchers found that men and women with either a severe or mild form of alcoholism differed little in their character profiles and etiologies. Women and men with moderately severe alcoholism, however, tended to differ with respect to co-occurring psychopathologies (e.g., depression or antisocial personality) and the degree to which they drank to relieve other conditions (e.g., boredom). These findings suggest that different forms of alcoholism treatment may be most effective for men and women with moderately severe alcoholism. However, as is the case with any subtyping scheme, this conclusion cannot be applied to the general population without further research.
Relations Among Children's Coping Strategies and Anxiety: The Mediating Role of Coping Efficacy

ABSTRACT The current study tests a model that depicts the relationships among coping strategies (active, distraction, avoidance, and support seeking) and anxiety symptoms. SEM is used to test if the relationship between these variables is mediated by coping efficacy. A large sample of Canadian children (N = 506) aged 8 to 11 years (boys = 249, girls = 245, unknown gender = 12) participated in the study. Results showed that coping efficacy is a partial mediator of the relations between active coping strategies and anxiety symptoms, however support was not found for it to be an effective mediator for other coping strategies. This study contributes to the understanding of childhood anxiety by highlighting the importance of the relationship between anxiety and the methods children use to cope with stress and how perceptions of their coping abilities influence this relationship.