Miracle-dz/UniFAR-FTUs huggingface dataset:
A Phase I Study of Flavopiridol in Combination With Gemcitabine and Irinotecan in Patients With Metastatic Cancer

Background:Flavopiridol (HMR 1275) is a synthetic flavone with antineoplastic properties through inhibition of cyclin-dependent kinase inhibitor. Flavopiridol synergizes in a sequence-dependent fashion with chemotherapy. Major adverse events of flavopiridol in single agent phase I studies are secretory diarrhea, neutropenia, thrombosis, and fatigue. Patients and Methods:Patients with advanced solid tumors were treated with gemcitabine 800 mg/m2 and irinotecan 80 mg/m2 on day 1, followed by flavopiridol, starting dose of 30 mg/m2 on day 2 with increment of 15 mg/m2 per dose level, repeated on days 8 and 9 for the first 6 patients (3-week cycle), and then repeated on days 15 and 16 for the remainder patients (4-week cycle). The protocol had to be amended for inability to redose after 1 week. Results:Fourteen women and 7 men with advanced solid tumors were enrolled. The median age was 51 years and the median number of prior chemotherapies was 3 (0–9). Neutropenic sepsis (1 patient), grade 3 diarrhea (1 patient), and neutropenia (2 patients) preventing retreatment on day 8 were observed among the 6 subjects treated on the first schedule. The recommended phase II dose of flavopiridol was 45 mg/m2 in combination with irinotecan and gemcitabine every 2 weeks. Dose-limiting toxicities were electrolyte imbalance with fatigue (1 patient), and renal failure and dyspnea with hypoxia (1 patient each), seen at 45 and 60 mg/m2 doses, respectively. The most common side effects were fatigue (81%), nausea (71%), diarrhea (67%), transient myelosuppression (43%), and vomiting (24%). Conclusions:The every 2 week dosing is well tolerated with a phase II recommended dose of 45 mg/m2 of flavopiridol in combination with irinotecan (80 mg/m2) and gemcitabine (800 mg/m2).
Patient Recruitment Methods to Evaluate Treatment Decision Making for Localized Prostate Cancer

Objective:To examine methods for identifying and recruiting prostate cancer patients prior to initiating treatment to gain insight into the treatment decision process and avoid recall bias. Study Design and Setting:One recruitment strategy involved providers and nursing staff approaching patients in community and academic urology clinics. The second recruitment strategy used electronic pathology reports to identify newly diagnosed cases in real time in an integrated health system. Our recruitment goal was to have patients complete the survey about the decision-making process prior to initiating therapy. Results:The two recruitment methods yielded different response rates. Of the 226 eligible participants approached in urology clinics, 187 (83%) returned a completed baseline survey. Of the 1177 surveys mailed to potentially eligible participants at KPNC, 617 (52%) returned a completed baseline survey. The number of surveys completed prior to treatment was 125 (67%) for the clinic recruitment approach and 437 (71%) for the electronic medical record approach. Younger participants and patients with less aggressive clinical characteristics were more likely to complete the survey before initiating treatment. Other patient demographic and clinical factors were not associated with the timing of survey return. Conclusions:Recruiting newly diagnosed patients prior to initiating treatment is feasible with both approach methods. The use of electronic medical records to identify subjects was more cost efficient, although it results in a lower response rate.
Different Types of Physical Activity on Inflammatory Biomarkers in Women With or Without Metabolic Disorders: A Systematic Review

Overwhelming data support the relationship between physical inactivity and inflammatory processes underlying metabolic disorders. The aim of this review was to assess critically the body of evidence for the relationships between exercise protocols and levels of inflammatory biomarkers in women. Systematic literature searches using PubMed Medline, Cochrane Central Register of Controlled Trials, Web of Science, LILACS, and SciELO of publications from 1993 to January 2012 were conducted using the following keywords: inflammation, cytokine, exercise, physical training, aerobic training, cardiovascular training, strength training, resistance training, interval training, cardiac rehabilitation, and therapeutic lifestyle modification/management. Three studies reported no significant changes in inflammatory status, one documented an increase in inflammatory biomarkers, and 12 articles reported decreased inflammatory biomarkers associated with exercise. Secondary lifestyle characteristics, such as strenuous physical labor or smoking, were correlated with levels of inflammatory biomarkers. Integrative interventions, including diet, moderate aerobic (60% to 80% of maximum heart rate, or 50% to 60% of VO2max) and circuit resistance training (8 to 10 exercises, 8 to 12 repetitions), health education, and counseling, used together, appeared to be effective strategies to improve inflammatory biomarkers in women.
Association Between Females’ Perceptions of College Aerobic Class Motivational Climates and Their Responses

The aim of this study was to examine the relationship between female college students’ perceptions of the motivational climate in their aerobics classes to their adaptive exercise responses. Data were collected from university group exercise classes in spring 2008. The participants (N = 213) responded to a questionnaire measuring perceptions of the climate (i.e., caring, task-, and ego-involving), correlates of intrinsic motivation (i.e., interest/enjoyment, perceived competence, effort/importance, and tension/pressure), commitment to exercise, and reasons for exercising. Canonical correlation analyses revealed that participants who perceived a predominately caring, task-involving climate reported higher interest/enjoyment, perceived competence, effort/importance, and commitment to exercise, as well as lower tension/pressure. Further, those who perceived a high caring, task-involving, and low ego-involving climate were also more likely to report more health-related reasons for exercise versus appearance-focused reasons. Results suggested that important motivational benefits might exist when women perceive caring, task-involving climates in their aerobics class settings. Aerobics class instructors who intentionally create caring, task-involving climates may promote more adaptive motivational responses among their female participants.
The Association Between Socioeconomic Status and Cardiovascular Risk Factors Among Middle-Aged and Older Men and Women

Studies of gender differences in the association between socioeconomic status (SES) and cardiovascular risk factors have produced mixed findings. The purpose of this research was to examine whether the association between SES and cardiovascular risk factors differed between older men and women. Using data on physical measures and biomarkers from the 2006 Health and Retirement Study (N = 2,502 men; N = 3,474 women), linear regression models were used to estimate the association between SES and seven cardiovascular risk factors. Interactions between gender and SES were tested. For all seven risks assessed, we observed significant associations of selected SES factors to cardiovascular risk for men and/or women. In all of these cases, lower SES was associated with higher cardiovascular risk. However, for six of the factors, we also observed gender differences in the association between SES and cardiovascular risk, such that lower SES was associated with higher cardiovascular risk for women but not for men. These findings suggest that the association between SES and cardiovascular risk is more pronounced for women than for men. Implementing interventions to reduce cardiovascular risk factors, particularly among older women with lower SES, might, over time, reduce cardiovascular disease in women and improve quality of life.
Lesões extra-renais de uremia em 72 cães

Between 1986 and 1995, 72 cases of uremia were diagnosed from 1,623 (4.43%) dogs necropsied at the Veterinary Pathology Lab of the "Universidade Federal de Santa Maria", RS, Brazil. Clinical signs of uremia were reported in 58 dogs (80.55%) and included mainly vomitus, anorexia, diarrhea and depression. Extrarenal lesions of uremia were most evident, in decreasing order of frequency, in the following organ systems: alimentary, respiratory, cardiovascular, endocrine and skeletal. More frequently observed lesions were uremic gastropathy (79.16%) and pneumopathy (49.27%), and mural endocarditis of the left atrium associated with degenerative arteriopathy of the coronary vessels (34.72%). Seventy (16.27%) out of 430 dogs with primary renal lesions had uremia. Two (14.2%) out of 14 dogs with obstruction of the urinary flow developed post-renal uremia. No case of pre-renal uremia was diagnosed. The renal lesions which induced uremia in the dogs were glomerulonephritis, acute tubular nephrosis, interstitial nephritis, infarction, bilateral cystadenocarcinoma, and amyloidosis. The age of affected dogs varied from 2 months to 12 years. The acute and subacute renal lesions were more frequent in dogs up to 5 years and the chronic renal lesions were more frequent in dogs from 6 to 12 years of age.
The Protective Effect of Moderate Alcohol Consumption on Ischemic Stroke

ContextModerate alcohol consumption has been shown to be protective for coronary heart disease, but the relationship between moderate alcohol consumption and ischemic stroke is more controversial.ObjectiveTo determine the association between alcohol consumption and risk of ischemic stroke.DesignPopulation-based case-control study conducted between July 1993 and June 1997.SettingMultiethnic population in northern Manhattan, New York, NY, aged 40 years or older.Patients and Other ParticipantsCases (n=677) had first ischemic stroke and were matched to community controls (n=1139) derived through random digit dialing by age, sex, and race/ethnicity. Mean ± SD age of cases was 70.0 ± 12.7 years; 55.8% were women; 19.5% were white, 28.4% black, and 50.7% Hispanic.Main Outcome MeasureFirst ischemic stroke (fatal or nonfatal). ResultsModerate alcohol consumption, up to 2 drinks per day, was significantly protective for ischemic stroke after adjustment for cardiac disease, hypertension, diabetes, current smoking, body mass index, and education (odds ratio [OR], 0.51; 95% confidence interval [CI], 0.39-0.67). This protective effect of alcohol consumption was detected in both younger and older groups, in men and women, and in whites, blacks, and Hispanics. In a quadratic model of stroke risk, increased risk of ischemic stroke was statistically significant among those consuming 7 or more drinks per day (OR, 2.96; 95% CI, 1.05-8.29). ConclusionsModerate alcohol consumption was independently associated with a decreased risk of ischemic stroke in our elderly, multiethnic, urban subjects, while heavy alcohol consumption had deleterious effects. Our data support the National Stroke Association Stroke Prevention Guidelines regarding the beneficial effects of moderate alcohol consumption.
Randomized Prospective Phase II Study to Compare the Combination Chemotherapy Regimen Epirubicin, Cisplatin, and 5-Fluorouracil With Epirubicin, Cisplatin, and Capecitabine in Patients With Advanced or Metastatic Gastric Cancer

ObjectivesThe aim of this study was to compare the efficacy and safety of the epirubicin, cisplatin, and continuous infusion of 5-fluorouracil (ECF) regimen with that of the epirubicin, cisplatin, and capecitabine (ECX) regimen in patients with advanced or metastatic gastric cancer. MethodsPatients were randomized to receive either the ECF or ECX regimen. The primary end point was the response rate. The secondary end points were time to progression (TTP), overall survival (OS), and safety. ResultsEighty-five patients were enrolled in the study from January 2003 to March 2007. Forty-five patients received the ECF regimen and 40 patients received the ECX regimen. The objective response rate was 31% [9% complete response (CR) and 22% partial response (PR)] for ECF and 30% (10% CR and 20% PR) for ECX. The disease control rate was 51% and 73%, respectively (P<0.05). Median OS and TTP were 6.8 and 5.5 months, respectively, in the ECF group and 8.3 and 6.0 months, respectively, in the ECX group. The majority of adverse events were grade 1/2. The most frequent grade 3/4 adverse events in both groups were fatigue (ECF 15%, ECX 21%), neutropenia (ECF 16%, ECX 16%), vomiting (ECF 11%, ECX 8%), nausea (ECF 9%, ECX 3%), and anemia (ECF 7%, ECX 5%). ConclusionsThe ECX regimen was at least as effective as the ECF regimen with a similar tolerability profile, and could therefore replace the ECF regimen for the first-line treatment of patients with advanced gastric cancer.
Factors associated with hysterectomy among older women from Latin America and the Caribbean

ABSTRACT To identify factors associated with hysterectomy, data collected from 1999–2000 were assessed from seven cities of the Health, Well-Being and Aging in Latin America and the Caribbean Study on 6,549 women, aged 60 years and older. Hysterectomy prevalence ranged from 12.8% in Buenos Aires (Argentina) to 30.4% in Bridgetown (Barbados). The median age for having had a hysterectomy ranged from 45 to 50 years across the cities and was 47 years in the pooled sample. Ethnic differences in hysterectomy rates were partially explained by differences across cities. Factors significantly associated with lower odds for hysterectomy included older age, household crowding conditions, and having public/military or no health insurance, compared to having private health insurance. Women who had three or more children were less likely to have had a hysterectomy, a finding that differs from most previous studies. Socioeconomic position related to rates of hysterectomy in late life rather than hysterectomies earlier in life. However, the nature of these differences varied across birth cohorts. The findings suggested that adverse socioeconomic factors were most likely related to hysterectomy risk by affecting access to health care, whereas parity was most likely acting through an effect on decision-making processes.
Prevalence and perception of self reported dentine hypersensivity among dentate populations in South-western Nigeria

Aim: To determine by questionnaire the prevalence and perception of DH in general dentate populations in south western Nigeria. Study Design: A descriptive study of self reported dentine hypersensitivity among dentate populations selected by multistage sampling technique in south western Nigeria. Subjects and methods: A structured questionnaire was administered to 373 subjects [170males, 203females, mean age 37.1 (standard deviation +/- 15.8years)] selected by multistage sampling technique in 4 dental clinics in Nigeria. Analysis was done using the Statistical Package for the Social Sciences (SPSS) version 12. Results: About 61% of the subjects (60.9%, n=227) reported to have experienced DH. Most of whom were of fifth decade, and significantly more in females (64.5%) and smokers (72.7%) than males (56.5%)[p Conclusion: Self reporting of DH was similar to previous studies. However, a thorough clinical examination could determine a more accurate prevalence data. Key Words: prevalence, dentin hypersensitivity, dentate populations, South-western Nigeria
Bortezomib-Cyclophosphamide-Dexamethasone for Relapsing Multiple Myeloma

ObjectivesIn vitro studies have shown synergistic antimyeloma effects with the combination of bortezomib and alkylating agents. Combinations of bortezomib, cyclophosphamide, and dexamethasone are rational with the prospect of superior antitumor activity with independent toxicity. MethodsBetween December 2004 and April 2007, we treated 44 patients with relapsing multiple myeloma with the combination of bortezomib 1.3 mg/m2 intravenously on days 1, 4, 8, 11; dexamethasone 20 mg/m2 orally daily for 4 days beginning on days 1, 9 and 17; and cyclophosphamide 70 mg/m2 orally twice daily for 4 days. A second course was given 1 month later. ResultsClinical response was observed in 32 patients (73%) including 26 with disease in partial remission (59%), and 6 with disease in complete remission (14%). Side effects were uncommon and mild, except for grade 3 thrombocytopenia in 15%, infection in 5% and constipation in 2% of patients. The median remission time of responding patients was 10 months that contributed to significantly longer median survival for patients with responsive disease (33 mo) than for those with unresponsive disease (12 mo) (P < 0.01). ConclusionBortezomib-cyclophosphamide-dexamethasone was an effective, well-tolerated combination for the treatment of relapsing multiple myeloma.
Relationship between adipokines and lipid profile in postmenopausal women with different apolipoprotein E genotypes

ABSTRACT The aim of the authors of this study was to clarify the relationships among apolipoprotein E (ApoE) genotype, blood pressure, lipid profile, serum leptin, and adiponectin in healthy postmenopausal women. The study was conducted between March 2011 and December 2012 on 266 participants aged 50–65 years from the Institute of Rural Health in Lublin, Poland. Results showed that women had four combinations of genotypes: ɛ2/ɛ3, ɛ3/ɛ3, ɛ3/ɛ4, and ɛ4/ɛ4. Carriers of different genotypes did not differ in terms of age, body mass index (BMI), blood pressure, total cholesterol, high-density lipoprotein (HDL) cholesterol, and adiponectin levels. Mean low-density lipoprotein (LDL) cholesterol levels were higher in ε4 carriers compared to non-carriers. Fasting serum leptin concentrations were higher in homozygotes ɛ4/ɛ4. Leptin correlated positively with BMI in all study groups and with LDL in ɛ2/ɛ3, ɛ3/ɛ3, and ɛ3/ɛ4. Adiponectin correlated negatively with triglycerides in ɛ2/ɛ3, ɛ3/ɛ3, and ɛ3/ɛ4 and positively with HDL in ɛ2/ɛ3 carriers. Adipokines were not associated with blood pressure. Multiple regression analyses demonstrated associations among leptin, ApoE ɛ4/ɛ4, BMI, and LDL, and among adiponectin, BMI, and triglycerides. In healthy postmenopausal women ɛ4/ɛ4 genotype was associated with lower leptin levels. Homozygosity ɛ4/ɛ4 was associated with a more atherogenic lipid profile and possibly dysregulation of leptin and adiponectin signaling in lipid metabolism.
Prevalence of Canine Parvovirus Infection in Street Dogs in Mymensingh Municipality area, Bangladesh

Canine parvovirus (CPV) is a highly contagious infectious disease of dog characterized by severe gastroenteritis but so far there is no first-hand data on CPV reported in Bangladesh. Therefore, this cross-sectional survey was carried out for the antigenic detection of CPV in thirty randomly selected street dogs captured throughout Mymensingh municipality of Bangladesh over the period from January to July 2010. Rectal swab samples were collected from all dogs and tested by CPV rapid Ag test. Overall prevalence of canine parvovirus disease was recorded as 30%. Prevalence of CPV was higher in young age group than that of older age groups. Male dogs were found to be higher susceptible to canine parvovirus infection in comparison with female. Significantly higher prevalence of CPV was recorded in diarrheic dogs compared with those having no diarrhea. Dogs with poor health condition were more vulnerable to canine parvovirus infection compared to those with normal health status. This is the first published report on CPV in street dogs in Bangladesh. DOI: http://dx.doi. org/10.3329/mh.v3i1. 19768 Microbes and Health, June 2014. 3(1): 5-6
Maternal psychological distress during pregnancy does not increase the risk for adverse birth outcomes

ABSTRACT Maternal psychological distress during pregnancy is a potential risk factor for various birth complications. This study aimed to explore psychological factors associated with adverse birth outcomes. Symptoms of psychological distress, individual characteristics, and medical complications were assessed at two time points antenatally in 285 women from Australia and New Zealand; birth outcomes were assessed postpartum, between January 2014 and September 2015. Hierarchical multiple regression analyses were conducted to examine the relation of psychological distress to adverse birth outcomes. Medical complications during pregnancy, such as serious infections, placental problems and preeclampsia, and antenatal cannabis use, were the factors most strongly associated with adverse birth outcomes, accounting for 22 percent of the total variance (p < .001). Symptoms of depression and/or anxiety, low social support, and low sense of coherence were not associated with birth complications. In unadjusted analyses, self-reported diagnosis of anxiety disorder during pregnancy and an orientation toward a Regulator mothering style were associated with adverse birth outcomes; however, after controlling for medical complications, these were no longer associated. Our study results indicate that antenatal depressive and/or anxiety symptoms were not independently associated with adverse birth outcomes, a reassuring finding for women who are already psychologically vulnerable during pregnancy.
The prevalence of self-reported premenstrual symptoms and evaluation of regular exercise with premenstrual symptoms among female employees in Taiwan

ABSTRACT Few studies have focused on premenstrual symptoms in employees. This study explored the prevalence of premenstrual symptoms in 7,193 female employees aged 18–55 years in a large electronics manufacturer in Taiwan from August 2014 to December 2014 and examined whether regular exercise was associated with premenstrual symptoms. Information was collected on demographics, lifestyle, menstrual history, menstrual pain, and premenstrual symptoms. Half of the participants reported irregular menstruation; 79.4% reported a moderate menstruation amount, and half reported little impact of menstrual pain at work. In order of prevalence, symptoms were “easy to fatigue” (24%), “backache” (21.2%), and “abdominal bloating” (17.4%). Participants who engaged in regular exercise reported fewer backaches (adjusted odds ratio [aOR] = 0.79, 95% confidence interval [CI] = 0.68–0.91), somatic discomfort (aOR = 0.78, 95% CI = 0.63–0.96), headache (OR = 0.82, 95% CI = 0.69–0.98), diarrhea (aOR = 0.76, 95% CI = 0.60–0.96), constipation (aaOR = 0.59, 95% CI = 0.44–0.78), less irritability (aOR = 0.78, 95% CI = 0.65–0.94), feeling morose and depressed (aOR = 0.75, 95% CI = 0.58–0.95), crying (aOR = 0.51, 95% CI = 0.27–0.87), and emotional lability (aOR = 0.73, 95% CI = 0.58–0.91). Regular exercise was associated with decreased menstrual pain (aOR = 0.85, 95% CI = 0.76–0.96). Our findings provide a better understanding of premenstrual symptoms in female workers, allowing for the development of premenstrual health programs to improve their health and quality of life.