Miracle-dz/UniFAR-FTUs huggingface dataset:
Combined pars plana vitrectomy and lens management in complex vitreoretinal disease

Concurrent cataract and vitreoretinal disorders are relatively common. Additionally, a considerable number of phakic eyes develop visually significant cataract following pars plana vitrectomy. The ophthalmic literature is replete with reports of a combined procedure consisting of simultaneous cataract extraction, intraocular lens implantation, and pars plana vitrectomy to treat a wide range of vitreoretinal disorders and co-existing cataracts. Historical concerns of increased risk of complications with the combined procedure have been shown not to be clinically significant. The combined procedure offers the advantages of a single procedure, including faster recovery time and cost effectiveness. Earlier reports of the combined procedure describe pars plana lensectomy and extracapsular cataract extraction as techniques for cataract extraction. Currently, phacoemulsification with implantation of a foldable posterior intraocular lens implantation has become the preferred technique of cataract removal. With advances in instrumentation and surgical techniques, the combined procedure offers a safe and effective way to manage concurrent cataract and complex vitreoretinal disease.
Brain Natriuretic Hormone Predicts Stress-Induced Alterations in Diastolic Function

Background:Mental stress (MS) reduces diastolic function (DF) and may lead to congestive heart failure with preserved systolic function. Whether brain natriuretic hormone (brain natriuretic peptide [BNP]) mediates the relationship of MS with DF is unknown. Methods:One hundred sixty individuals aged 30 to 50 years underwent 2-hour protocol of 40-minute rest, videogame stressor and recovery. Hemodynamics, pro-BNP samples and DF indices were obtained throughout the protocol. Separate regression analyses were conducted using rest and stress E/A, E′ and E/E′ as dependent variables. Predictor variables were entered into the stepwise regression models in a hierarchical fashion. At the first level, age, sex, race, height, body mass index, pro-BNP and left ventricular mass (LVM) were permitted to enter the models. The second level consisted of systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR). The final level contained cross-product terms of race by SBP, DBP and HR. Results:E/A ratio was lower during stress compared to rest and recovery (P < 0.01). Resting E/A ratio was predicted by a regression model of age (−0.31), pro-BNP (0.16), HR (−0.40) and DBP (−0.23) with an R2 = 0.33. Stress E/A ratio was predicted by age (−0.24), pro-BNP (0.08), HR (−0.38) and SBP (−0.21) with total R2 = 0.22. Resting E′ model consisted of age (−0.22), pro-BNP (0.26), DBP (−0.27) and LVM (−0.15) with an R2 = 0.29. Stress E′ was predicted by age (−0.18), pro-BNP (0.35) and LVM (−0.18) with an R2 = 0.18. Resting E/E′ was predicted by race (0.17, B > W) and DBP (0.24) with an R2 = 0.10. Stress E/E′ consisted of pro-BNP (−0.36), height (−0.26) and HR (−0.21) with an R2 = 0.15. Conclusions:pro-BNP predicts both resting and stress DF, suggesting that lower BNP during MS may be a marker of diastolic dysfunction in apparently healthy individuals.
Timing, order and durability of new product advantages with imitation

This research examined the effects of timing, order and the durability of first mover advantages by analyzing the stock market reactions to new product introductions and imitations. The major findings are that both timing and order of moves are important and that rival reactions undermine the durability of first mover advantages. More specifically, (1) early and fast movers achieve greater gains than late and slow movers, and (2) first movers suffer at the time of new product imitations. Copyright © 2000 John Wiley & Sons, Ltd.
Extended visual fixation in young infants: look distributions, heart rate changes, and attention.

Visual fixation in infants from 3 to 6 months of age was examined for its fit to the theory of "attentional inertia. " This theory posits that during the progression of a look there is increasing attention toward the stimulus and an "inertia" to continue looking. An extended audiovisual stimulus was presented for 20 min to infants while fixation was videotaped and heart rate (HR) was recorded. Consistent with the attentional inertia theory, look duration toward the stimulus had a lognormal distribution. Hazard functions describing these distributions showed a decreasing conditional probability of looking away with increases in look duration. Look onset and stimulus changes that occurred within a look were accompanied by HR deceleration. The average HR level continued to decrease over the duration of a look and returned to prestimulus level immediately prior to the fixation offset. Infant fixation has characteristics similar to fixation in children and adults, and attention appears to increase over the course of a look in young infants.
Inducible nitric oxide synthase expression in chronic viral hepatitis and its relation with histological severity of disease

summary. The role of nitric oxide in the pathogenesis of chronic viral hepatitis is not known. Elevated nitric oxide production is assumed to be responsible for the pathological changes in many inflammatory conditions, mainly via peroxynitrite, a potential oxidant that is produced by the reduction of superoxide anion with nitric oxide. The intensity and the distribution of the immunohistochemical staining of intrahepatic inducible nitric oxide synthase were studied in the biopsy specimens obtained from 63 patients with viral hepatitis and 13 patients with elevated transaminase levels of various aetiologies. Hepatic inducible nitric oxide synthase staining was significantly more intense in the viral hepatitis group (P = 0.000). Inducible nitric oxide synthase staining levels correlated well with the severity of the viral hepatitis using the Knodell's liver histological activity index (r = 0.393, P = 0.002) Among the viral hepatitis group, the pathological distribution of the inducible nitric oxide synthase staining favoured the periportal hepatocytes (zone 1) whereas less staining was observed in parenchymal hepatocytes zone of 2 and 3 and bile duct epithelium. As nitric oxide mediated nitration of hepatocellular proteins is elevated in inflamed hepatic tissues and is correlated with the severity of the disease, we suggest that inducible nitric oxide synthase can possibly have a critical role in the pathogenesis of chronic viral hepatitis.
A secure lightweight and fair exchange protocol for NFC mobile payment based on limited-use of session keys

The use of NFC mobile payment has increased dramatically over the last few years. The huge number of payment transactions has caused an increase in the economic growth rate. However, NFC mobile payment protocol still have insufficient security properties and fairness. In this paper, we recommend a novel NFC mobile payment protocol for m-payment that offer both fair exchange and information security in a POS (Point of Sale) transaction processing system. Moreover, methods of offline session key generation and distribution are implemented in order to improve the security, whilst keeping the property lightweight. According to our analysis, the results have shown that our protocol tends to be more efficient and effective than others, with regards to the properties of security and fairness.
Clarification of the Mechanism of Clopidogrel-Mediated Drug–Drug Interaction in a Clinical Cassette Small-dose Study and Its Prediction Based on In Vitro Information

Clopidogrel is reported to be associated with cerivastatin-induced rhabdomyolysis, and clopidogrel and its metabolites are capable of inhibiting CYP2C8 and OATP 1B1 in vitro. The objective of the present study was to identify the mechanism of clopidogrel-mediated drug–drug interactions (DDIs) on the pharmacokinetics of OATP1B1 and/or CYP2C8 substrates in vivo. A clinical cassette small-dose study using OATPs, CYP2C8, and OATP1B1/CYP2C8 probe drugs (pitavastatin, pioglitazone, and repaglinide, respectively) with or without the coadministration of either 600 mg rifampicin (an inhibitor for OATPs), 200 mg trimethoprim (an inhibitor for CYP2C8), or 300 mg clopidogrel was performed, and the area under the concentration–time curve (AUC) ratios (AUCRs) for probe substrates were predicted using a static model. Clopidogrel increased the AUC of pioglitazone (2.0-fold) and repaglinide (3.1-fold) but did not significantly change the AUC of pitavastatin (1.1-fold). In addition, the AUC of pioglitazone M4, a CYP2C8-mediated metabolite of pioglitazone, was reduced to 70% of the control by coadministration of clopidogrel. The predicted AUCRs using the mechanism-based inhibition of CYP2C8 by clopidogrel acyl-β-glucuronide were similar to the observed AUCRs, and the predicted AUCR (1.1) of repaglinide using only the inhibition of OATP1B1 did not reach the observed AUCR (3.1). In conclusion, a single 300 mg of clopidogrel mainly inhibits CYP2C8-mediated metabolism by clopidogrel acyl-β-glucuronide, but its effect on the pharmacokinetics of OATP1B1 substrates is negligible. Clopidogrel is expected to have an effect not only on CYP2C8 substrates, but also dual CYP2C8/OATP1B1 substrates as seen in the case of repaglinide.
The Right Ventricle in Pulmonary Arterial Hypertension: Disorders of Metabolism, Angiogenesis and Adrenergic Signaling in Right Ventricular Failure

The right ventricle (RV) is the major determinant of functional state and prognosis in pulmonary arterial hypertension. RV hypertrophy (RVH) triggered by pressure overload is initially compensatory but often leads to RV failure. Despite similar RV afterload and mass some patients develop adaptive RVH (concentric with retained RV function), while others develop maladaptive RVH, characterized by dilatation, fibrosis, and RV failure. The differentiation of adaptive versus maladaptive RVH is imprecise, but adaptive RVH is associated with better functional capacity and survival. At the molecular level, maladaptive RVH displays greater impairment of angiogenesis, adrenergic signaling, and metabolism than adaptive RVH, and these derangements often involve the left ventricle. Clinically, maladaptive RVH is characterized by increased N-terminal pro–brain natriuretic peptide levels, troponin release, elevated catecholamine levels, RV dilatation, and late gadolinium enhancement on MRI, increased 18fluorodeoxyglucose uptake on positron emission tomography, and QTc prolongation on the ECG. In maladaptive RVH there is reduced inotrope responsiveness because of G-protein receptor kinase–mediated downregulation, desensitization, and uncoupling of &bgr;-adrenoreceptors. RV ischemia may result from capillary rarefaction or decreased right coronary artery perfusion pressure. Maladaptive RVH shares metabolic abnormalities with cancer including aerobic glycolysis (resulting from a forkhead box protein O1–mediated transcriptional upregulation of pyruvate dehydrogenase kinase), and glutaminolysis (reflecting ischemia-induced cMyc activation). Augmentation of glucose oxidation is beneficial in experimental RVH and can be achieved by inhibition of pyruvate dehydrogenase kinase, fatty acid oxidation, or glutaminolysis. Therapeutic targets in RV failure include chamber-specific abnormalities of metabolism, angiogenesis, adrenergic signaling, and phosphodiesterase-5 expression. The ability to restore RV function in experimental models challenges the dogma that RV failure is irreversible without regression of pulmonary vascular disease.
An Evaluation of the Effectiveness of a Commercial Mechanical Trap to Reduce Abundance of Adult Nuisance Mosquito Populations

Abstract In this study, we explore the potential of a commercially available mechanical mosquito control device, the Liberty Plus Mosquito Magnet® (hereafter referred to as Mosquito Magnet), to reduce the abundance of adult nuisance mosquito populations in public recreational areas. Mosquitoes were trapped on 2 replicate sites close to a campground at Brae Island Regional Park near Fort Langley, British Columbia, Canada. Each site comprised a treatment (Mosquito Magnets used) and control subsection (Mosquito Magnets not used). Mosquito numbers were assessed before and after the treatment period in both subsections at each site with Centers for Disease Control and Prevention (CDC) black light traps. Although nearly 200,000 mosquitoes from 14 different species were collected over 366 trap-nights from May 31 to July 31, 2008, the majority of those identified were Aedes sticticus (68%) and Ae. vexans (22%)—2 of the most notorious nuisance mosquito species in British Columbia. The number of mosquitoes captured by CDC black light traps increased overall during the study period due to natural seasonal variation. Nevertheless, a significant treatment effect (P = 0.0389) was associated with an average decrease of about 32% in the average number of adult mosquitoes collected per day. These results strongly suggest that Mosquito Magnets can reduce the abundance of nuisance mosquitoes, potentially reducing the biting pressure on the public, and providing another tool in mosquito control operations.
Nucleocytoplasmic Shuttling by Human Immunodeficiency Virus Type 1 Vpr

ABSTRACT Human immunodeficiency virus type 1 (HIV-1) is capable of infecting nondividing cells such as macrophages because the viral preintegration complex is able to actively traverse the limiting nuclear pore due to the redundant and possibly overlapping nuclear import signals present in Vpr, matrix, and integrase. We have previously recognized the presence of at least two distinct and novel nuclear import signals residing within Vpr that, unlike matrix and integrase, bypass the classical importin α/β-dependent signals and do not require energy or a RanGTP gradient. We now report that the carboxy-terminal region of Vpr (amino acids 73 to 96) contains a bipartite nuclear localization signal (NLS) composed of multiple arginine residues. Surprisingly, when the leucine-rich Vpr(1–71) fragment, previously shown to harbor an NLS, or full-length Vpr is fused to the C terminus of a green fluorescent protein-pyruvate kinase (GFP-PK) chimera, the resultant protein is almost exclusively detected in the cytoplasm. However, the addition of leptomycin B (LMB), a potent inhibitor of CRM1-dependent nuclear export, produces a shift from a cytoplasmic localization to a nuclear pattern, suggesting that these Vpr fusion proteins shuttle into and out of the nucleus. Studies of nuclear import with GFP-PK–Vpr fusion proteins in the presence of LMB reveals that both of the leucine-rich α-helices are required for effective nuclear uptake and thus define a unique NLS. Using a modified heterokaryon analysis, we have localized the Vpr nuclear export signal to the second leucine-rich helix, overlapping a portion of the amino-terminal nuclear import signal. These studies thus define HIV-1 Vpr as a nucleocytoplasmic shuttling protein.
Intrathecal methylprednisolone for intractable postherpetic neuralgia.

BACKGROUND There is no effective treatment for intractable postherpetic neuralgia. Because there is evidence that postherpetic neuralgia has an inflammatory component, we assessed treatment with intrathecally administered methylprednisolone to reduce pain in patients with this disorder. METHODS We enrolled 277 patients who had had intractable postherpetic neuralgia for at least one year, 270 of whom were followed for two years. The patients were randomly assigned to receive intrathecal methylprednisolone and lidocaine (3 ml of 3 percent lidocaine with 60 mg of methylprednisolone acetate, 89 patients), lidocaine alone (3 ml of 3 percent lidocaine, 91 patients), or no treatment (90 patients) once per week for up to four weeks. Each weekly dose was injected into the lumbar intrathecal space. Pain was evaluated before randomization, at the end of the treatment period, and then four weeks, one year, and two years later. Samples of cerebrospinal fluid were obtained for measurement of interleukin-8 before and at the end of the treatment period. RESULTS There was minimal change in the degree of pain in the lidocaine-only and control groups during and after the treatment period. In the methylprednisolone-lidocaine group, the intensity and area of pain decreased, and the use of the nonsteroidal antiinflammatory drug diclofenac declined by more than 70 percent four weeks after the end of treatment. No complications related to intrathecal methylprednisolone were observed. Before treatment, the concentrations of interleukin-8 in the cerebrospinal fluid were inversely related to the duration of neuralgia in all the patients (r=-0.49, P<0.001). In the patients who received methylprednisolone, interleukin-8 concentrations decreased by 50 percent, and this decrease correlated with the duration of neuralgia and with the extent of global pain relief (P<0.001 for both comparisons). CONCLUSIONS The results of this trial indicate that the intrathecal administration of methylprednisolone is an effective treatment for postherpetic neuralgia.
Early use of cyclic TPN prevents further deterioration of liver functions for the TPN patients with impaired liver function.

BACKGROUND/AIMS Impaired liver function is frequently found in patients who need prolonged total parenteral nutrition. Cyclic total parenteral nutrition can minimize the adverse effects of long-term total parenteral nutrition, such as hepatic complication. The adequate timing to shift to use cyclic total parenteral nutrition for patients with impaired liver function may prevent further hepatic dysfunction. METHODOLOGY A prospective study of 65 patients who need total parenteral nutrition and have impaired liver functions was performed. Cyclic total parenteral nutrition was used in different groups of patients, when their total bilirubin levels were just over 5 mg%, 10 mg%, or 20 mg% during the course of total parenteral nutrition. The patients of control groups received straight non-cyclic total parenteral nutrition. All the patients had stable vital signs without major stress, such as sepsis or acute bleeding. Ten patients (A2) in Group A were shifted to cyclic total parenteral nutrition when their total bilirubin was just over 5 mg%; the other 10 patients (A1) continued the non-cyclic total parenteral nutrition. Eleven patients (B2) in Group B were shifted to cyclic total parenteral nutrition when their total bilirubin was just over 10 mg%; the other 11 patients (B1) continued the non-cyclic total parenteral nutrition. Ten patients (C2) in Group C were shifted to cyclic total parenteral nutrition when their total bilirubin was just over 20 mg%; the other 13 patients (C1) continued the non-cyclic total parenteral nutrition. The average energy intake among 3 groups had no difference. Their liver functions were examined each week for 2 weeks. RESULTS The results showed that the patients with non-cyclic total parenteral nutrition had significant increase of direct-total bilirubin and alkaline phosphatase (P < 0.05) in Group A and significant decrease of albumin accompanied with increase of GOT, GPT, direct/total bilirubin (P < 0.05) in Group B. The patients either using cyclic or non-cyclic total parenteral nutrition showed significant decrease of albumin and increase of direct/total bilirubin (P < 0.05) in Group C. CONCLUSIONS We conclude that the early use of cyclic total parenteral nutrition may prevent deterioration of liver function for the patients with jaundice and need prolonged total parenteral nutrition.
Electronic Commerce within the Chinese Banking Industry

Electronic Commerce (EC) enables business transactions to be conducted electronically, offering many benefits to organisations. While EC has been widely adopted across industry sectors in developed countries, its adoption in developing countries has not been widespread. At the moment, there are relatively fewer studies of EC adoption in developing countries compared to those in developed countries and hence little is known why and how to accelerate the EC adoption in developing countries. This paper explores the adoption of EC within the banking industry of China, as an example of a developing country. The findings of this study are useful to better understand the drivers of EC adoption, the potential of EC and the issues faced by the Chinese banking industry. Other developing countries may also benefit from the findings of this study by establishing their awareness of the EC potential as well as possible barriers that they need to confront in the adoption of EC.
[Spacing and limiting components of the fertility transition in Latin America].

Trends in marital fertility according to rural or urban residence, wife's educational level, and husband's occupation are analyzed for 6 Latin American countries which participated in both the World Fertility Survey and Demographic and Health Surveys. The countries were Colombia, Dominican Republic, Ecuador, Mexico, Peru, and Trinidad and Tobago. The principal methodological tool for this analysis is a statistical model of period marital fertility which expresses fertility as a function of spacing, which is assumed to operate equally in all durations of union, and of limiting, which increases in importance as the duration of union increases. The model permits a summary description of the levels and patterns of marital fertility and yields parameters that may be interpreted in terms of basic behavioral mechanisms, such as lactation and contraception. Total marital fertility in the 6 countries decreased in the recent past, with the magnitude of decline varying from . 4 births/woman in Trinidad and Tobago to 2.2 in Mexico. The results indicate that the transition originated in an educated urban minority and has spread to almost all strata studied. Most of the observed fertility decline resulted from birth limitation, but spacing played a surprisingly large role. Despite the diversity of conditions in the 6 countries, the indices of spacing and limiting in the different social strata appeared to have followed a single pattern of increase over time. Although the trajectory followed by the indices of spacing and limiting is sufficiently broad to accomodate substantial differences between the countries, it is well defined, indicating that a common explanation exists. It is demonstrated that the pattern of increase is consistent with a simple mathematical model of social diffusion.
Type of Vascular Access and Survival among Very Elderly Hemodialysis Patients

The use of central venous catheters (CVC) for hemodialysis (HD) is associated with higher mortality compared to arteriovenous access (AV). However, studies analyzing the influence of the type of vascular access on the survival of very elderly patients (≥75 years) initiating HD are few and involve only a limited number of patients. We studied a cohort of 5,466 incident patients who started HD; of these, 1,841 were aged ≥75. Types of vascular access for HD were classified as either CVC, which included both tunneled and non-tunneled catheters, or AV, which included AV fistula and grafts. The outcome of the study was all-cause mortality during the follow-up period. In the whole cohort, AV use was associated with a survival advantage over CVC use (88 and 63% at 2 and 5 years, respectively, in patients with an AV as compared to 75 and 48% in patients with a CVC) (p < 0.0001). Among patients ≥75, CVC use was associated with a higher number of deaths compared to AV use. Patients ≥75 with an AV showed a greater survival as compared to patients ≥75 with a CVC (80 and 53% at 2 and 5 years, respectively, vs. 68 and 43%; p < 0.0001). Multivariate analysis revealed that CVC use and the presence of arrhythmia were independent risk factors of death in patients ≥75, whereas obesity was associated with greater survival. In conclusion, the type of vascular access has a significant influence on the survival of very elderly patients (≥75) initiating HD. CVC use was associated with poorer survival compared to AV access.