Miracle-dz/UniFAR-FTUs huggingface dataset:
Supervisor Support and Career Anchor Impact on the Career Satisfaction of the Entry-Level Information Systems Professional

Keeping satisfied information systems (IS) professionals at the entry level has become a difficult task for IS managers. Financial incentives have led to escalating costs without widespread improvement of the situation. To capitalize on nonfinancial rewards, organizations must understand the relationships between employees' internal desires, the environment fostered by the organization, and career satisfaction. This paper is a report on a study of 101 entry-level IS professionals. The data analysis indicates that IS professionals find more satisfaction with their career when supervisor support is prominent and an adequate range of opportunities that satisfy career desires exist within the organization.
Chicken or the egg: ST elevation in lead aVR or SYNTA X score

Summary Background: ST-segment elevation in lead aVR (STEaVR) anticipates left main and/or three-vessel disease (LM/3VD) in patients with acute coronary syndromes. STEaVR is generally reciprocal to and accompanied by ST-segment depression (STD) in the precordial leads. SYNTAX score (SS) is an angiographic scoring system and is widely used to evaluate the severity and complexity of coronary artery disease. The purpose of our study was to assess the relationship between STEaVR and SS. Methods: We performed a retrospective analysis of 117 patients with non-ST-segment elevation acute coronary syndrome (NSTEACS). Electrocardiograms at presentation were reviewed, especially for ST-segment elevation of ≥ 0.05 mV in lead aVR and STD of ≥ 0.05 mV in more than two contiguous leads. All lesions causing ≥ 50% stenosis in a coronary artery with a diameter of ≥ 1.5 mm were included in the SS calculation. SS was divided into two groups: ≥ 23: high, < 23: low. Results: Among the 117 patients, 80 (68.4%) had STEaVR and 37 (31.6%) did not. Patients with STEaVR had a higher SS and higher rate of LM/3VD (85 vs 67.6%, p < 0.001; 86.2 vs 72.9%, p = 0.03, respectively) than those without STEaVR. On multivariate analysis, STEaVR [odds ratio (OR) 1.85; 95% confidence interval (CI): 1.20–3.97, p = 0.03] and STD in leads V1–V4 (OR 2.14; 95% CI: 1.46–4.23, p = 0.002) were independent predictors of a high SS. Conclusion: This study demonstrated that STEaVR was an independent predictor of a high SS.
Serum Interleukin-6 Levels in Differential Diagnosis of Sepsis and Transient Tachypnea of Newborn

Objectives: The aim of this study was to evaluate the role of serum interleukin-6 (IL-6) levels in the differentiation of neonatal bacterial sepsis and TTN. Patients and Methods: The hospital records of 58 newborns with respiratory distress that were above 35 weeks of gestational age were investigated. Patients were divided into two groups. The infection group consisted of patients with proven sepsis and clinical sepsis and the remaining one was TTN group. Clinical findings and white blood cell count, serum C-reactive protein (CRP), IL-6 levels and the ratio of immature neutrophils to total neutrophils count (I/T) were recorded and were compared between the two groups. Results: Serum CRP and IL-6 levels were found higher than normal limits in both of the groups. However there was no significant difference between them. Duration of respiratory distress was longer and I/T ratio was significantly higher in the infection group than TTN group. Conclusion: I/T ratio and IL-6 may contribute to the early diagnosis of sepsis with respiratory symptoms in newborn but IL-6 alone can not distinguish TTN and sepsis. Amac: Bu calismanin amaci yenidoganlarda serum interlokin 6 duzeyinin bakteriyel sepsis ve yenidoganin gecici takipnesinin ayriminda rolunun arastirilmasidir. Hastalar ve Yontemler: Solunum sikintisi olan ve gestasyonel yasi 35 haftadan buyuk olan 58 yenidogan calismaya alindi. Hastalar, kanitlanmis veya klinik sepsisi olanlar ve yenidoganin gecici takipnesi olanlar olmak uzere iki gruba ayrildi. Klinik bulgular beyaz kure sayisi, C reaktif protein, serum IL-6 duzeyi, periferik yaymada immature notrofil sayisinin toplam notrofil sayisina orani kaydedilerek gruplar arasinda karsilastirildi. Bulgular: Her iki grupta da serum CRP ve IL-6 duzeyleri normal limitlerden yuksek bulunmasina ragmen iki grup arasinda fark yoktu. Solunum sikintisinin suresi ve I/T orani yenidoganin gecici takipnesi olan grupta belirgin olarak fazla bulundu. Sonuc: IL-6 ve I/T orani solunum sikintisi olan sepsisli yenidoganlarin erken tanisi konusunda katkida bulunurken IL-6 duzeyi tek basina yenidoganlarda sepsis ve yenidoganin gecici takipnesinde kullanilamaz.
Assessing changes in availability of land and water for food (1960–2050)

Future global food demand will require more land and water. We group the global population into six “Gross Domestic Product groups” and study changes in the availability of land and water for food in relation to demographic and nutrition transition theories. We show large differences in land and water availability between rich and poor countries. Inequality will strongly increase due to the projected large population growth in poor countries. By 2050, the richest quarter of the global population will have three times more arable land per person than the rest. Those changing diets to a more affluent consumption will be the ones with less available resources per person. More than two-thirds of global population will not have enough land to produce the food for an affluent diet by 2050. Thus, the large land and water constraints of the poor will result in significant challenges for food security than predicted in previous studies.
Hemiepiphysiodesis for Idiopathic Genu Valgum: Percutaneous Transphyseal Screw Versus Tension-band Plate

Background: The aim of this study was to compare the outcomes of angular deformity correction by percutaneous hemiepiphysiodesis using transphyseal screw (PETS) or tension-band plating (TBP) in growing children with idiopathic genu valgum with emphasis on the rate of deformity correction. Methods: We retrospectively reviewed cases of hemiepiphysiodesis for angular deformity in lower extremities between 2009 and 2014. A total of 90 limbs in 33 patients received PETS and 60 limbs in 24 patients received TBP. Angular measurements were compared preoperatively and at the time of hardware removal. The amount and rate of angular deformity correction were compared between the 2 groups. Potential factors affecting correction velocity were investigated using multivariate analysis. Results: Angular correction was achieved in all patients. The mean rate of correction was more rapid with PETS than with TBP at both the distal femur (0.92 vs. 0.64 deg./mo, respectively; P<0.001) and proximal tibia (0.72 vs. 0.55 deg./mo, respectively; P=0.019). Multivariate analysis showed that the used implant significantly affected the rate of correction: PETS demonstrated faster correction velocity than TBP (−0.26, 95% confidence interval, −0.35 to −0.17, P<0.001). Conclusions: Both PETS and TBP techniques result in satisfactory correction of coronal angular deformity in patients with idiopathic genu valgum. However, the observed rate of correction was faster with PETS than TBP. Correction with PETS, rather than TBP, may better serve patients near skeletal maturity. Level of Evidence: Level III—retrospective comparative series.
Specific interaction of the RNA-binding domain of the bacillus subtilis transcriptional antiterminator GlcT with its RNA target, RAT.

Expression of the Bacillus subtilis ptsGHI operon is controlled by transcriptional antitermination mediated by the antiterminator protein GlcT. The antiterminator is inactivated in the absence of glucose, presumably by phosphorylation. A conditional terminator in the ptsG mRNA leader region has been identified. Mutations in this terminator resulted in constitutive expression of the operon. The terminator is overlapped by an inverted repeat (called ribonucleic-antiterminator, RAT) which is thought to form a stem-loop structure upon binding of the antiterminator protein GlcT. The N-terminal 60 amino acid residues of GlcT are able to bind to the RAT and prevent transcriptional termination in vivo. Sequence-specific interaction between the RNA-binding domain and the RAT was demonstrated by surface plasmon resonance analysis. Mutations affecting the RNA-binding domain were isolated and will be discussed with respect to their consequences for dimerization and RNA binding.
Plasma Homovanillic Acid as an Index of Central Dopaminergic Activity: Studies in Schizophrenic Patients

Despite the limitations of the dopamine hypothesis, compelling evidence remains that implicates dysfunction of CNS dopamine systems in the pathophysiology of schizophrenia. The longitudinal measurement of levels of plasma HVA has proved a useful tool in studying neuroleptic effects and has highlighted time-dependent effects as a potentially important facet of the mechanism of antipsychotic action of these drugs. Despite the good clinical correlates of plasma HVA levels, caution is needed in interpreting plasma levels of HVA with regard to CNS dopamine activity. The peripheral nervous system significantly contributes to levels of HVA that circulate in plasma. This issue is underscored by the fact that CSF HVA shows different neuroleptic response patterns than that seen in plasma. The administration of a peripherally acting MAO inhibitor to enhance the CNS "signal" in circulating levels of HVA does not resolve the "problem" of different CSF-plasma HVA neuroleptic response patterns. The possibility that mesocortical dopamine activity is reflected by CSF HVA is suggested by indirect evidence from clinical and preclinical studies. Future studies in which attempts are made at using both plasma and CSF HVA to enhance neurochemical and clinical correlates may help to advance our understanding of the contributions of specific CNS dopamine systems to schizophrenia.
A Clustered Randomized Trial of an Educational Intervention During Transplant Evaluation to Increase Knowledge of Living Donor Kidney Transplant

Introduction: Maximizing education about living donor kidney transplant (LDKT) during the in-person evaluation at the transplant center may increase the numbers of kidney patients pursuing LDKT. Research Questions and Design: To test the effectiveness of a 1-time LDKT educational intervention, we performed a cluster-randomized trial among 499 patients who presented for evaluation of kidney transplant. We compared usual care education (n = 250) versus intensive LDKT education (n = 249), which was implemented only on the evaluation day and consisted of viewing a 25-minute video of information and stories about LDKT and discussion of LDKT possibilities with an educator. Our primary outcome was knowledge of LDKT, 1 week after the transplant evaluation. Results: One week after evaluation, patients who received intensive education had higher knowledge than patients who received usual care (12.7 vs. 11.7; P = .0008), but there were no differences in postevaluation readiness for LDKT. Among patients who had not previously identified a potential living donor, receiving intensive education was associated with increased willingness to take steps toward LDKT. Discussion: In conclusion, expansion of LDKT education within the evaluation day may be helpful, but interventions that are implemented at multiple times and for greater duration may be necessary to ensure larger and long-term behavioral changes in pursuit of LDKT.
Mandibular third molar angulation in extraction and non extraction orthodontic cases.

BACKGROUND The purpose of this study is to determine the angulation of mandibular third molar in orthodontic cases which are planned for extraction and non extraction. METHODS This is a cross-sectional descriptive study in which pre-treatment panoramic radiographs of 49 patients, age range 11-26 years were taken from the OPD of Department of Orthodontics, Dr. Ishrat- ul -Ebad Khan Institute of Oral and Health Sciences (DIKIOHS), Dow University of Health Sciences. The angles between the long axis of the second and third molars were measured. Descriptive statistics were applied. Mann-Whitney U-test was used for intergroup comparison extraction and non extraction cases. RESULTS This study consists of 49 patients with mean age of 17.94 years. Over all result concluded that mandibular third molar angulations were from 8-94 degrees in extraction cases and 10-73 degrees in non extraction cases. However, the pre-treatment 3rd molar angulation differences in extraction and non extraction cases were statistically insignificant with p-value >0.05. CONCLUSIONS This study evaluates third molar angulations in pre-treatment cases, the differences in angulation were like other morphological differences but changes in angulation after treatment may or may not be related to extractions.
Osteopontin augments CD3‐mediated interferon‐γ and CD40 ligand expression by T cells, which results in IL‐12 production from peripheral blood mononuclear cells

Osteopontin is an RGD‐containing bone matrix protein with cytokine‐like functions that is associated with early stages of Th1‐mediated diseases. Although the function of osteopontin in these responses is unknown, it is expressed by activated T cells and macrophages and can costimulate T cell proliferation. Studies have demonstrated that early IL‐12 and IFN‐γ expression is required to induce a protective response to many intracellular pathogens. Herein, we demonstrate that osteopontin stimulation augments the ability of anti‐CD3 monoclonal antibody to induce CD40 ligand (CD40L) and IFN‐γ expression on human T cells, resulting in CD40L‐ and IFN‐γ‐dependent IL‐12 productionin vitro. These findings suggest a functional role for osteopontin in early Th1 responses, namely regulation of T cell‐dependent IL‐12 production. Further, osteopontin up‐regulation of CD40L provides mechanistic support for the association of osteopontin with polyclonal B cell proliferation and humoral autoimmune disease.
Using a population-based observational cohort study to address difficult comparative effectiveness research questions: the CEASAR study.

BACKGROUND While randomized controlled trials represent the highest level of evidence we can generate in comparative effectiveness research, there are clinical scenarios where this type of study design is not feasible. The Comparative Effectiveness Analyses of Surgery and Radiation in localized prostate cancer (CEASAR) study is an observational study designed to compare the effectiveness and harms of different treatments for localized prostate cancer, a clinical scenario in which randomized controlled trials have been difficult to execute and, when completed, have been difficult to generalize to the population at large. METHODS CEASAR employs a population-based, prospective cohort study design, using tumor registries as cohort inception tools. The primary outcome is quality of life after treatment, measured by validated instruments. Risk adjustment is facilitated by capture of traditional and nontraditional confounders before treatment and by propensity score analysis. RESULTS We have accrued a diverse, representative cohort of 3691 men in the USA with clinically localized prostate cancer. Half of the men invited to participate enrolled, and 86% of patients who enrolled have completed the 6-month survey. CONCLUSION Challenging comparative effectiveness research questions can be addressed using well-designed observational studies. The CEASAR study provides an opportunity to determine what treatments work best, for which patients, and in whose hands.
New organochlorine contaminants and metabolites in plasma and eggs of glaucous gulls (Larus hyperboreus) from the Norwegian Arctic

The present study investigated new or lesser‐studied and legacy organochlorine (OC) contaminants and metabolites in plasma and eggs of glaucous gulls (Larus hyperboreus) collected from major breeding colonies on Bear Island in the Norwegian Arctic. Hexachlorobutadiene was below the method limit of detection (<0.07 ng/g lipid wt) in all samples. The sum (sum) of 20 chlorobornane congener concentrations ranged between 294 and 986 ng/g lipid weight and 104 and 1,121 ng/g lipid weight in plasma and eggs, respectively, whereas those of ∑20polychlorinated naphthalene ranged between 1.34 and 126 ng/g lipid weight in plasma and 1.82 and 162 ng/g lipid weight in eggs. Bis(4‐chlorophenyl) sulfone concentrations ranged between 5.24 and 143 ng/g lipid weight plasma, which is the first report of this contaminant in arctic biota north of Sweden. Based on 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin toxic equivalents (TEQs), partial dioxin‐like toxicity varied between 3.04 and 20.8 ng TEQ/g lipid weight in plasma and 0.94 and 46.5 ng TEQ/g lipid weight in eggs, and largely was due to concentrations of non‐ortho polychlorinated biphenyls (PCBs), with a very minor contribution from mono‐ortho PCBs and polychlorinated naphthalenes. The major aryl sulfone metabolite in plasma was an unidentified hexachlorinated MeSO2‐PCB congener (range: 13.5–551 ng/g lipid wt), whereas the pentachlorinated congeners 3′‐ and 4′‐MeSO2‐CB101 (range: 4.49–38.1 ng/g lipid wt) dominated in eggs. The predominant halogenated phenolic compound (HPC) in plasma was consistently the PCB metabolite 4‐OH‐CB187 (range: 0.29–17.5 ng/g wet wt), whereas in eggs, detectable HPCs were at very low and transient concentrations. As part of a complex profile of contaminant exposure, these chemical classes and metabolites may be contributing factors to enhance physiological stress in breeding glaucous gulls.
Role of the divalent metal ion in sugar binding, ring opening, and isomerization by D-xylose isomerase: replacement of a catalytic metal by an amino acid.

The distinct roles of the two magnesium ions essential to the activity of D-xylose isomerase from Streptomyces olivochromogenes were examined. The enzyme-magnesium complex was isolated, and the stoichiometry of cation binding determined by neutron activation analysis to be 2 mol of magnesium per mole of enzyme. A plot of Mg2+ added versus Mg2+ bound to enzyme is consistent with apparent KD values of < or = 0.5-1.0 mM for one Mg2+ and < or = 2-5 mM for the second. A site-directed mutant of D-xylose isomerase was designed to remove the tighter, tetracoordinated magnesium binding site (site 1, Mg-1); Glu180 was replaced with Lys180. The stoichiometry of metal binding to this mutant, E180K, is 1 mol of magnesium per mole of enzyme. Ring-opening assays with 1-thioglucose (H2S released upon ring opening) show E180K catalyzes the opening of the sugar ring at 20% the rate of the wild-type, but E180K does not catalyze isomerization of glucose to fructose. Thus, the magnesium bound to Glu180 is essential for isomerization but not essential for ring opening. The X-ray crystallographic structures of E180K in the absence of magnesium and in the presence and absence of 250 mM glucose were obtained to 1.8-A resolution and refined to R factors of 17.7% and 19.7%, respectively. The wild-type and both E180K structures show no significant structural differences, except the epsilon-amino group of Lys180, which occupies the position usually occupied by the Mg-1. (ABSTRACT TRUNCATED AT 250 WORDS)
A comparison of the stress‐response sequence in new and experienced pediatric oncology nurses

Oncology nurses experience a variety of occupational stresses. Different support measures have been provided for these nurses, but with mixed effects. This is likely because exact stressors, reactions, and consequences of the stressors differ among groups of oncology nurses, and a support measure appropriate for one group may be ineffective for another group. The purpose of this descriptive study was to identify the specific components of the stress-response sequence in new and experienced pediatric oncology nurses. Twenty-five nurses participated in guided interviews; nine of these comprised a new nurse orientation group, and 14 nurses were randomly selected from all nurses in the setting who had been in the specialty a minimum of 18 months. The new nurses were interviewed at 3, 6, and 12 months posthire, and the experienced nurses were interviewed one time. Interview data were content analyzed, and codes and definitions were developed for each component of the stress-response sequence. Distinct differences in stressors, reactions, and consequences were noted between new nurses who resigned before the 12th month of employment and those who did not, and between new nurses and experienced nurses; new nurses had few coping reactions, and their most common reaction was resignation. Experienced nurses had a greater number and different types of coping reactions and more positive consequences. Descriptive profiles were developed from the codes and can be used as a basis for tailored support measures for pediatric oncology nurses.
Trunk Extensor EMG – Torque Relationship

The integrated surface electromyogram (IEMG) of the lumbar erectores spinae and the torque generated were simultaneously recorded from 27 healthy subjects in the standing posture while they pulled isometrically against resistance provided by a harness around the shoulders. The IEMG – torque ratio (efficiency of electrical activity, or EEA) was used to characterize each subject. Individual recordings showed evidence of nonlinearity of the IEMG–torque relationship in that a statistically better fit to experimental recordings was obtained by using two straight lines with a breakpoint between them. However, with repeated testing, the gradients of these two lines were more variable than the slope of the single straight line fitted to the entire recording. The slope of the best fit line (EEA) was less for recordings made during torque decrease than for increasing-torque recordings. This also showed as a “hysteresis” pattern in the recordings. The coefficient of variability (within subjects) of the EEA was greater in day-to-day testing (24%) than with repeated pulls at the same testing session (14%). This was similar to variability of the maximum generated torque. About 25% of the variability between subjects was found to be due to anthropometric differences. The residual variability of the relationship would limit the accuracy of IEMG as a measure of muscular effort under changing torque conditions. However, the EEA may be useful for characterizing muscle performance, especially when maximum effort cannot be achieved.