Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of Negative Pressure Wound Therapy on Cellular Fibronectin and Transforming Growth Factor-β1 Expression in Diabetic Foot Wounds

Background: Chronic diabetic foot wounds are a leading cause of amputation, morbidity, and hospitalization for patients with diabetes. Negative-pressure wound therapy (NPWT) can putatively facilitate wound healing, but the underlying mechanisms remain unclear. Cellular fibronectin (cFN) and transforming growth factor-β1 (TGF-β1) play an important role in wound healing. This prospective randomized controlled trial evaluated the effects of NPWT on the production of cFN and the expression of TGF-β1 in diabetic foot wounds of patients. Methods: From January 2012 to January 2015, 40 patients with diabetic foot wounds were randomly and equally apportioned to receive either NPWT or advanced moist wound therapy (control) for 7 days. Granulation tissue was harvested before and after treatment. Immunohistochemistry and Western blot were performed to evaluate protein levels of cFN and TGF-β1, and real-time polymerase chain reaction (PCR) to measure corresponding mRNA expressions. Results: NPWT facilitated the expression of cFN and TGF-β1 in diabetic foot wounds. Immunohistochemical analysis revealed higher levels of cFN and TGF-β1 in the NPWT group than in the control group. Western blot and real-time PCR analysis further showed that protein and mRNA levels of cFN or TGF-β1 were higher in the NPWT group than that in the control group (P < .01, both). Conclusion: Our results showed that NPWT facilitated the production of cFN and the expression of TGF-β1 in granulation tissue in diabetic foot ulcers. Level of Evidence: Level I, randomized controlled study.
Driving less for better air: Impacts of a public information campaign

In the wake of the 1990 amendments to the Clean Air Act, localities across the United States initiated public information campaigns both to raise awareness of threats to air quality and to change behavior related to air pollution by recommending specific behavioral changes in the campaign messages. These campaigns are designed to reduce the health hazards associated with poor air quality and to avoid federal sanctions resulting from the failure to meet air quality standards. As in many other communities across the country, a coalition of government agencies and businesses initiated a public information campaign in the Atlanta metropolitan region to reduce certain targeted behaviors, mainly driving. A two-stage model used to analyze data from a rolling sample survey shows that the centerpiece of the information campaign-air quality alerts-was effective in raising awareness and reducing driving in a segment of the population. When the overall information campaign was moderated by employers' participation in programs to improve air quality, drivers significantly reduced the number of miles they drove and the number of trips they took by car on days when air quality alerts were sounded. Public information campaigns can be successful in increasing awareness, but changing well-established behaviors, such as driving, is likely to require institutional mediation to provide social contexts that support the behavioral change, as well. © 2003 by the Association for Public Policy Analysis and Management.
Movement and the Rubber Hand Illusion

When a participant views a rubber hand being stroked by a paintbrush while his/her real hand is unseen and similarly stroked by another paintbrush, a misperception known as the rubber hand illusion occurs whereby tactile sensations are falsely referred to the non-body part. The purpose of the current study was to further examine the rubber hand illusion with conditions of movement. An apparatus was devised that would synchronise visual with felt movement in an active condition and a passive condition. An asynchronous condition was included as a control in which visual and felt movement were purposely disconnected. The three movement conditions (active, passive, and asynchronous) were statistically compared in order to assess our prediction that synchronous conditions of movement (especially active) would generate more reports of the illusion. The performance of the movement conditions was evaluated against a visual-tactile condition, which is a known contributor to the rubber hand illusion. Not only significantly more robust reports of the illusion were obtained when visual movement and felt movement were synchronised but there was also a trend toward stronger reports in the active condition rather than the passive condition. Interestingly, the pattern of results differed according to the particular question on the self-report.
Waist-hip ratio and low HDL predict the risk of coronary artery disease in Pakistanis

SUMMARY Objective: To establish risk factor causal associations for coronary artery disease (CAD) in the native Pakistani population. Methods: We conducted a hospital-based, case-control study of 200 cases with angiographically documented CAD and 200 age-and sex-matched controls without angiographic evidence of CAD. Patients on lipid lowering therapy were excluded. Lifestyle, anthropometric and biochemical risk factors were assessed in both groups. Results: The presence of CAD was associated with current, past or passive smoking, a history of diabetes and high blood pressure, a positive family history of CAD, body fat percentage, waist-hip ratio (WHR), low apolipoprotein A1 or low HDL, lipoprotein (a), glucose, insulin, insulin resistance, C-reactive protein (CRP), total cholesterol to HDL ratio (TC/HDL) and creatinine on univariate conditional logistic regression analysis. In multiple regression analysis, significant independent associations were found with low HDL (OR 0.11; 95% CI 0.04–0.34; p < 0.001) positive family history (OR 1.79; 95% CI 1.09-2.93; p = 0.02), CRP (OR 1.45; 95% CI 1.19–1.75; p < 0.001) and WHR (OR 1.04; 95% CI 1.01-1.08; p = 0.01). Angiograms were also quantified for the extent and severity of CAD by the Gensini scoring system. Quantitative angiographic data showed associations with age (p = 0.01), the duration of diabetes (p = 0.04), WHR (p = 0.06), low HDL (p < 0.001), lipoprotein (a) (p = 0.001), creatinine (p < 0.001) and CRP (p = 0.007). Results indicate that total and LDL cholesterol were not significant risk factors in this study; levels were below currently accepted thresholds for treatment. Conclusions: The cardiovascular risk profile in this population is consistent with metabolic syndrome where low HDL and WHR can be used to predict the risk of CAD. Results suggest the need to redefine the currently practised approach to CAD management in this population to fit local needs.
Operation and control of a hybrid photovoltaic-diesel-fuel cell system connected to micro-grid

This paper presents modeling and control of a hybrid Photovoltaic (PV), Diesel-Engine Generator (DEG) - Fuel Cell (FC) system connected to electric grid. A case study on impact of FC operation on the frequency stability of electric grid has been carried out. The model of fuel cell system includes a fuel cell generator, electrolyzer and a hydrogen storage facility. The limits on hydrogen volume due to limited storage capacity have also been incorporated. The modeling of photovoltaic is also presented and analyzed for a time period of 24-hours with varying solar radiation and temperature. Results of simulation indicate that FC system can contribute to frequency stability in both cases when the load increases and also when the load drops. This feature of FC system will be helpful if it is operated along with a hybrid Wind-PV System.
Effects of Noise, Nonlinear Processing, and Linear Filtering on Perceived Speech Quality

Objectives: The purpose of this study was to measure subjective quality ratings in listeners with normal hearing and listeners with hearing loss for speech subjected to a wide range of processing conditions that are representative of real hearing aids. Design: Speech quality was assessed using a rating scale in a group of 14 listeners with normal hearing and 15 listeners with mild to moderately severe sensorineural hearing loss. Controlled simulations of hearing aid processing were used to process speech that included speech subjected to (1) noise and nonlinear processing, (2) linear filtering, and (3) combinations of noise, nonlinear processing, and linear filtering. The 32 conditions of noise and nonlinear processing included stationary speech-shaped nose, multitalker babble, peak clipping, quantization noise, spectral subtraction, and dynamic range compression (in quiet, with babble, and with spectral subtraction). The 32 linear filtering conditions included high-pass filtering, low-pass filtering, band-pass filtering, positive and negative spectral tilt, and resonance peaks. Subsets of these conditions were used for the 36 conditions that combined noise and nonlinear processing with linear processing. Results: Both listeners with normal hearing and listeners with hearing loss gave consistent (reliable) ratings. In both listener groups, sound quality was significantly affected by the noise, nonlinear processing, and linear filtering conditions. Compared with the listeners with normal hearing, the listeners with hearing loss showed significantly lower ratings of sound quality in nearly all of the processing conditions. For the conditions included in the current hearing aid simulation, noise and nonlinear conditions had a greater effect on quality judgments than did the linear filtering conditions. Conclusions: The data reported here provide a comprehensive dataset of speech quality ratings for simulated hearing aid processing conditions. The results indicate that quality ratings by listeners with hearing loss are significantly lower than quality ratings by listeners with normal hearing. In addition, quality ratings by listeners with hearing loss are impacted by signal processing at least as much as, and often more than, the quality ratings by listeners with normal hearing. Finally, quality ratings for speech processed with a simulated hearing aid are impacted more by noise and nonlinear signal processing than by linear filtering.
Breath alcohol estimation training: behavioral effects and predictors of success.

AIMS Breath alcohol concentration (BrAC) estimation training has been effective in increasing estimation accuracy in social drinkers. Predictors of estimation accuracy may identify populations to target for training, yet potential predictors typically are not evaluated. In addition, the therapeutic efficacy of estimation training as a preventive strategy for problematic drinking is unknown. METHODS Forty-six social drinkers with a recent binge history were randomly assigned to an intervention or control group (n = 23 per group). In each of three sessions (pretraining, training, testing), participants consumed alcohol (0.32, 0.24, 0.16 and 0.08 g/kg, in random order) every 30 min (total dose: 0.8 g/kg). Participants provided five BrAC estimates within 3 h of alcohol administration. The intervention group, but not control group, received internal and external training. During testing, participants provided BrAC estimates, but received no feedback. Participants returned for two follow-up visits to complete self-report measures. RESULTS BrAC estimation training improved intervention group estimation accuracy within the laboratory. Together, training, low trait anxiety and low risk expectancy predicted high testing accuracy. There were no significant group differences in subsequent alcohol consumption, behavior under the influence or risk expectancy regarding potentially hazardous behaviors. CONCLUSION BrAC estimation training is effective in the laboratory but may not translate into naturalistic settings.
Prophylactic vena cava filter insertion in patients with traumatic spinal cord injury: preliminary results.

Pulmonary embolism (PE) is a devastating complication in patients with traumatic spinal cord injury (SCI). Prophylactic measures such as venous compression hose or low-dose heparin are only partially protective in reducing the risk of venous thromboembolism and are contraindicated in some patients. Because of extended perturbations in fibrinolytic activity, catecholamine effects on platelet aggregation, increased activity of complement and acute phase reactants, abnormally high factor VIII concentrations, and persistent venous stasis with ongoing endothelial damage, the patient with an SCI remains at prolonged risk for venous thromboembolism. A retrospective 5-year review at the Medical Center Hospital of Vermont revealed seven patients with eight documented PEs (three fatal; 2.7%) in 111 SCI patients (6.3%). Six PEs (75%) occurred after discharge from the acute care facility. Median time to PE after injury was 78 days (range, 9-5993). Although comprising only 4% of all trauma admissions, SCI accounted for 31% of all PEs in the total trauma population (2525 patients). Beginning in July 1991, a new prophylaxis protocol was instituted, which included the percutaneous insertion of vena cava filters under local anesthesia in all SCI patients with paraplegia or quadriplegia. Fifteen patients have undergone the insertion of titanium filters. Impedance plethysmography was performed weekly to detect deep venous thrombosis. No complications were associated with vena cava filter insertion. No patients developed deep venous thrombosis during their acute hospitalization (median, 22 d), and no patients have developed PE after filter insertion. (ABSTRACT TRUNCATED AT 250 WORDS)
Skin lesion classification from dermoscopic images using deep learning techniques

The recent emergence of deep learning methods for medical image analysis has enabled the development of intelligent medical imaging-based diagnosis systems that can assist the human expert in making better decisions about a patients health. In this paper we focus on the problem of skin lesion classification, particularly early melanoma detection, and present a deep-learning based approach to solve the problem of classifying a dermoscopic image containing a skin lesion as malignant or benign. The proposed solution is built around the VGGNet convolutional neural network architecture and uses the transfer learning paradigm. Experimental results are encouraging: on the ISIC Archive dataset, the proposed method achieves a sensitivity value of 78.66%, which is significantly higher than the current state of the art on that dataset.
Harnessing Technological and Non-technological Innovations for SMEs Profitability in the Nigerian Manufacturing Sector

Science, Technology and Innovation (STI) have played a significant role in driving manufacturing sector of the advanced economies. This study examines the impact of technological and non-technological innovations as well as size of firm on the profitability of SMEs. The study was conducted using questionnaire among the manufacturing SMEs in Nigeria with a total of 365 of them correctly filled and analyzed using qualitative and Ordinary Least Squares techniques. The result revealed that process innovation (p-value<0.041) and product innovation (p-value<0.078) which represent technological innovation, marketing innovation (p-value<0.089) which represents non-technological innovation and size of firms (p-value<0.005) were significant in driving the turnover of the SMEs, whereas organisational innovation was not significant at 10% level of significance. The study therefore suggests that the manufacturing SMEs should continuously engage in both technological and non-technological innovations to improve their productivity, which will further increase their contribution to the Nigeria’s GDP.
The impact of diabetic retinopathy on health-related quality of life.

PURPOSE OF REVIEW To review recent evidence evaluating the effect of diabetic retinopathy and diabetic macular edema on health-related quality of life. RECENT FINDINGS A search of PubMed was conducted according to a strategy that combined the text words 'diabetic retinopathy' and 'quality of life' (n = 91; November 11, 2004) and 'diabetic macular edema' and 'quality of life' (n = 6; November 22, 2004). The Methods sections of all abstracts were reviewed for valid generic or disease-specific instruments used to evaluate health-related quality of life. In addition, abstracts were reviewed to ensure that the study sample was made up predominantly of diabetic individuals. Recent data suggest that persons with diabetic retinopathy are willing to trade off significant time to eliminate their ocular condition (mean time tradeoff score = 0.77-0.8) and that laser photocoagulation can improve health-related quality of life (significant improvement noted in 8 of 11 domains in the National Eye Institute Visual Function Questionnaire). In addition, recent research has noted that health-related quality of life can become affected in persons with diabetic retinopathy prior to visual loss, primarily because of anxiety about the future and emotional reaction to diagnosis and treatment. SUMMARY From a search of the literature, several recent articles could be identified that demonstrated both a qualitative and a quantitative reduction in health-related quality of life in persons with diabetic retinopathy. With many novel treatments being explored for the management of diabetic retinopathy and diabetic macular edema, measuring health-related quality of life will likely play an important role both in the decision to offer treatment and in monitoring relevant health gains that may be derived from intervention.
Factors Associated with Occupational Stress and Their Effects on Organizational Performance in a Sudanese University

Occupational stress has a significant impact on student learning and thereby on the contribution that such institutions can make to society. This affects organizational performance by reducing productivity and efficiency which affect the organization negatively. The aim of the current study was to determine the factors associated with occupational stress and their relationship with organizational performance at one of the private universities in Sudan. A total of 150 male and female employees from different departments and with various educational levels in the main building of the university were randomly selected. Data was collected using a questionnaire with background questions, job stressors such as role conflict and ambiguity, lack of participation in decision making, lack of authority, workload, unsatisfactory working conditions and interpersonal relationships, and statements about the effect on organisational performance. Questions were based on three- and four-point scale. Responses were grouped in terms of scores to show the level of job stress. Descriptive statistics was carried out using SPSS programme. Results indicated that on average the employees experienced high degree of job stress. Job stressors affected the general physical health of employees, their job satisfaction and performance as well as their commitment negatively. Similar findings were reported in other studies. The study recommended that the university needs to elevate the situation and resolve all the factors affecting the employees by for example increasing the number of staff needed to perform the tasks and/or decreasing the number of students enrolled.
Actinomycin D as the primary agent for gestational trophoblastic disease

Thirty‐one patients with nonmetastatic trophoblastic disease (NMTD) and 39 patients with metastatic trophoblastic disease (MTD) of gestational origin were treated primarily with actinomycin D. Complete and sustained remission was achieved with actinomycin D alone in 94% of patients with NMTD and 67% with MTD. In the nonmetastatic group, 93% of patients without choriocarcinoma (non‐CCA) achieved remission with actinomycin D, as compared to 100% (only 3 patients) with CCA. In the metastatic group, 76% of patients without CCA achieved remission with actinomycin D, as compared to 56% where CCA was present. Fourteen of the 15 patients who failed to respond completely to actinomycin D alone subsequently responded to methotrexate (10 patients), triple therapy (3 patients), methotrexate plus triple therapy (1 patient), and methotrexate plus vinblastine (1 patient). One patient died with widespread metastases despite intensive chemotherapy with actinomycin D and triple therapy. No serious toxic side effects were encountered even in treated patients with pre‐existing laboratory evidence of impaired hepatic function.
Diagnostic, Predictive, Prognostic, and Therapeutic Molecular Biomarkers in Third Millennium: A Breakthrough in Gastric Cancer

Introduction Gastric cancer is the fifth most common cancer and the third cause of cancer death. The clinical outcomes of the patients are still not encouraging with a low rate of 5 years' survival. Often the disease is diagnosed at advanced stages and this obviously negatively affects patients outcomes. A deep understanding of molecular basis of gastric cancer can lead to the identification of diagnostic, predictive, prognostic, and therapeutic biomarkers. Main Body This paper aims to give a global view on the molecular classification and mechanisms involved in the development of the tumour and on the biomarkers for gastric cancer. We discuss the role of E-cadherin, HER2, fibroblast growth factor receptor (FGFR), MET, human epidermal growth factor receptor (EGFR), hepatocyte growth factor receptor (HGFR), mammalian target of rapamycin (mTOR), microsatellite instability (MSI), PD-L1, and TP53. We have also considered in this manuscript new emerging biomarkers as matrix metalloproteases (MMPs), microRNAs, and long noncoding RNAs (lncRNAs). Conclusions Identifying and validating diagnostic, prognostic, predictive, and therapeutic biomarkers will have a huge impact on patients outcomes as they will allow early detection of tumours and also guide the choice of a targeted therapy based on specific molecular features of the cancer.
Information Content of Hedge Fund Equity Option Holdings

Using a novel sample of 13F reports, the authors document that hedge funds prefer to purchase equity options whose characteristics are particularly well-suited for informed trading. They show that hedge funds purchase liquid high-embedded leverage options without lottery-like skewness. Consistent with informed trading, they find that directional options held by hedge funds deliver superior returns. Although 13F holdings are reported with a 45-day lag, the authors demonstrate that investors can earn profits by utilizing publicly available information on hedge funds’ option holdings. They confirm that hedge funds’ options add value to the total portfolios, indicating that options are economically significant.
Sensitivity and Specificity of Information Criteria

Information criteria (ICs) based on penalized likelihood, such as Akaike’s Information Criterion (AIC), the Bayesian Information Criterion (BIC), and sample-size-adjusted versions of them, are widely used for model selection in health and biological research. However, different criteria sometimes support different models, leading to discussions about which is the most trustworthy. Some researchers and fields of study habitually use one or the other, often without a clearly stated justification. They may not realize that the criteria may disagree. Others try to compare models using multiple criteria but encounter ambiguity when different criteria lead to substantively different answers, leading to questions about which criterion is best. In this paper we present an alternative perspective on these criteria that can help in interpreting their practical implications. Specifically, in some cases the comparison of two models using ICs can be viewed as equivalent to a likelihood ratio test, with the different criteria representing different alpha levels and BIC being a more conservative test than AIC. This perspective may lead to insights about how to interpret the ICs in more complex situations. For example, AIC or BIC could be preferable, depending on the relative importance one assigns to sensitivity versus specificity. Understanding the differences and similarities among the ICs can make it easier to compare their results and to use them to make informed decisions.