Miracle-dz/UniFAR-FTUs huggingface dataset:
Manual handling incident claims in the healthcare sector: Factors and outcomes.

UNLABELLED Manual handling (MH) incidents may result in injury, absenteeism and/or compensation claim. OBJECTIVE This study investigated the factors associated with MH incidents among healthcare workers who had made a claim, and the management and outcome of those workers. PARTICIPANTS A national sample of healthcare sector MH incident claim files (n=247) were accessed and 35~files met the inclusion criteria. METHODS Data were collected and presented graphically or descriptively using percentages (and 95% Confidence intervals, CI). Chi-square (χ2) tests were used for comparing proportions between groups. SPSS (v14.0) was used for analysis. Significance at p<0.05 is assumed. RESULTS Attendants accounted for the highest number of claimants. The majority of claims (74%, 95% CI 68%, 81%) were for back injury; 11% (8%, 15%) for neck injury. Fifty-one percent (43%, 60%) involved patient-handling tasks at the time of incident; 46% (37%, 54%) involved inanimate handling. Ninety-one percent (89%, 94%) took sick leave, with 52% (43%, 60%) taking > 52 weeks. Only 58% (49%, 65%) returned to work. Claimants who had been in communication with employers were significantly more likely to return to work than those who did not (χ2 test, p=0.017). CONCLUSIONS Improved management of MH incidents and injured workers are recommended.
The 5-Year EFS of Multisystem LCH With Risk-Organ Involvement Is Suboptimal: A Single-center Experience From India

The study describes an 8-year experience of a single center in managing patients with langerhans cell histiocytosis on the basis of the langerhans cell histiocytosis-III platform. A retrospective case-file review of children diagnosed during 2006 to 2013 was performed. Group 1 (multisystem with risk-organ involvement) patients received an initial treatment of 6 to 12 weeks, followed by continuation treatment to complete 12 months. Drugs included vinblastine, prednisolone, and 6-mercaptopurine. Group 2 (multisystem without risk-organ involvement) patients received a similar treatment, except for 6-mercaptopurine. Group 3 (single-system/multifocal bone disease) patients were treated for a duration of 6 months. Forty-nine patients were treated: 24 (49%), 14 (28.6%), and 11 (22.4%) in groups 1, 2, and 3, respectively. The mean age at diagnosis was 31.6±28.4 months (range, 4 to 120 mo). Five patients abandoned treatment. There were 7 deaths, all in group 1. All patients who died had either a partial response or progressive disease after induction (P=0.000). Among patients with liver involvement, those with sclerosing cholangitis had a greater mortality (P=0.007). A relapse was observed in 12 (24.5%) patients. The frequency of relapse was not different in the 3 groups (P=0.833). The 5-year event-free survival in groups 1, 2, and 3 was 29.3±10%, 58.9±14.6%, and 69.3±15%, respectively (P=0.019). The 5-year overall survival was 100% in groups 2/3 and 68.9±9.8% in group 1 (P=0.011).
Scenarios of livestock – related greenhouse gas emissions in Austria

Abstract This paper compares existing livestock emissions and projections on three different spatial levels (global, European, national) and on two sets of system boundaries (inventory data and emission data considering the whole lifecycle). It aims to provide insight in the validity of scenario data of national Austrian livestock emissions. This entails the use of national greenhouse gas emission trends until 2030 – specifically for Austria – as well as EU-based assessments of country emissions up to 2050. In addition, global emission data was extracted from the representative concentration pathways (RCPs) database for the years 2000–2100. Extending national emission projections up to 2100 by combining different datasets connects national emission policies to international strategies. It becomes clear that the goal of keeping average global temperature rise under 2 °C (represented by RCP2.6), even in the medium term to 2030 and only looking at the livestock sector, is much more ambitious than any of the national projections. Furthermore, inventory emission data is set in contrast to emission data considering the whole lifecycle of meat products in Austria, with an overview of assessments from pork and beef production. Emissions reported in inventories represent roughly half of those assigned to the livestock sector in life cycle studies.
The Sound of Others: Surprising Evidence of Conformist Behavior

In this article we use the “Click” version of the Bomb Risk Elicitation Task to explore preferences for conformism. In the task subjects can infer the behavior of others from the mass of clicks heard. This signal is uninformative about the precise choices of the other participants, and never mentioned in the instructions. We control the exposure of subjects to clicks by implementing treatments with and without earmuffs. We further test the effect of the introduction of a common rather than individual resolution of uncertainty, still keeping individual payoffs independent of other subjects’ choices. We find strong evidence of conformist behavior even in such an inhospitable environment. Simply hearing the others clicking marginally affects subjects behavior. Introducing a common random draw results in a dramatic shift of the average choices toward risk loving, in particular by women, which is consistent with social preference considerations.
Duration of slip-resistant shoe usage and the rate of slipping in limited-service restaurants: results from a prospective and crossover study

Several studies have indicated that slip-resistant shoes may have a positive effect on reducing the risk of slips and falls, a leading cause of injury at work. Few studies, however, have examined how duration of shoe usage affects their slip-resistance properties. This study examined the association between the duration of slip-resistant shoes usage and the self-reported rate of slipping in limited-service restaurant workers. A total of 475 workers from 36 limited-service restaurants in the USA were recruited to participate in a 12-week prospective study of workplace slipping. Of the 475 participants, 83 reported changing to a new pair of shoes at least once during the 12-week follow-up. The results show that slip-resistant shoes worn for less than six months were moderately more effective than those worn for more than six months. Changing to a new pair of shoes among those wearing slip-resistant shoes at baseline was associated with a 55% reduction in the rate of slipping (RR = 0.45, 95% CI = 0.23–0.89). Further research is needed to develop criteria for the replacement of slip-resistant shoes. Practitioner Summary: The duration of usage impacts the slip-resistance properties of slip-resistant shoes. Slip-resistant shoes worn for less than six months were moderately more effective in reducing slips than slip-resistant shoes worn for more than six months. Shoe use policies should not only encourage or require their use but also include guidance on replacing slip-resistant shoes at regular intervals.
Comparative analysis of the ternary complex factors Elk‐1, SAP‐1a and SAP‐2 (ERP/NET).

A transcription factor ternary complex composed of Serum Response Factor (SRF) and Ternary Complex Factor (TCF) mediates the response of the c‐fos Serum Response Element (SRE) to growth factors and mitogens. Three Ets domain proteins, Elk‐1, SAP‐1 and ERP/NET, have been reported to have the properties of TCF. Here we compare Elk‐1 and SAP‐1a with the human ERP/NET homologue SAP‐2. All three TCF RNAs are ubiquitously expressed at similar relative levels. All three proteins contain conserved regions that interact with SRF and the c‐fos SRE with comparable efficiency, but in vitro complex formation by SAP‐2 is strongly inhibited by its C‐terminal sequences. Similarly, only Elk‐1 and SAP‐1a efficiently bind the c‐fos SRE in vivo; ternary complex formation by SAP‐2 is weak and is substantially unaffected by serum stimulation or v‐ras co‐expression. All three TCFs contain C‐terminal transcriptional activation domains that are phosphorylated following growth factor stimulation. Activation requires conserved S/T‐P motifs found in all the TCF family members. Each TCF activation domain can be phosphorylated in vitro by partially purified ERK2, and ERK activation in vivo is sufficient to potentiate transcriptional activation.
Effect of agomelatine treatment on C-reactive protein levels in patients with major depressive disorder: an exploratory study in “real-world,” everyday clinical practice

Objective Agomelatine is a newer antidepressant but, to date, no studies have been carried out investigating its effects on C-reactive protein (CRP) levels in major depressive disorder (MDD) before and after treatment. The present study aimed (i) to investigate the effects of agomelatine treatment on CRP levels in a sample of patients with MDD and (ii) to investigate if CRP variations were correlated with clinical improvement in such patients. Methods 30 adult outpatients (12 males, 18 females) with a Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) diagnosis of MDD were recruited in “real-world,” everyday clinical practice and treated with a flexible dose of agomelatine for 12 weeks. The Hamilton Rating Scale for Depression (HAM-D) and the Snaith-Hamilton Pleasure Scale (SHAPS) were used to evaluate depressive symptoms and anhedonia, respectively. Moreover, serum CRP was measured at baseline and after 12 weeks of treatment. Results Agomelatine was effective in the treatment of MDD, with a significant reduction in HAM-D and SHAPS scores from baseline to endpoint. CRP levels were reduced in the whole sample, with remitters showing a significant difference in CRP levels after 12 weeks of agomelatine. A multivariate stepwise linear regression analysis showed that higher CRP level variation was associated with higher baseline HAM-D scores, controlling for age, gender, smoking, BMI, and agomelatine dose. Conclusions Agomelatine’s antidepressant properties were associated with a reduction in circulating CRP levels in MDD patients who achieved remission after 12 weeks of treatment. Moreover, more prominent CRP level variation was associated with more severe depressive symptoms at baseline.
Does the size of a binge matter?

OBJECTIVE The aim of this study was to examine whether objective and subjective binges differ significantly from each other in relation to measures of psychopathology in a sample of women who meet DSM-IV diagnostic criteria for bulimia nervosa. METHOD Baseline data from the Eating Disorder Examination (EDE) were analyzed and the average of the sum of and the difference between objective and subjective binge episodes were converted to z scores. Regressions were run with other baseline measures including the Structured Clinical Interview for Diagnosis of DSM-III-R (SCID) I and II disorders, EDE subscales, and psychological measures. RESULTS We found no significant difference between the two types of binges on all but one measure, the "Can Do" subscale of the Self-Efficacy Questionnaire, in a regression with the z score of total binges. DISCUSSION The lack of significant findings questions the diagnostic validity of the "large amount of food" criterion used to define binge eating in the DSM-IV.
Optimal Design of Bank Bailouts: The Case of Prompt Corrective Action

The paper investigates the optimal design of bank bailouts in economies where banks can hide loan losses, and focuses on banking regulation via two Prompt Corrective Action instruments: prohibition of dividends and early closure policy. The first has a mitigating effort on moral hazard and regulator’s costs but the second instrument has a damaging impact. As to bad debts and the cleaning of banks’ balance sheets, asset insurance for the bank’s loan portfolio, bank capital and prohibition of dividends motivate banks to disclose loan losses.
A network analysis of anger, shame, proposed ICD-11 post-traumatic stress disorder, and different types of childhood trauma in foster care settings in a sample of adult survivors

ABSTRACT Background: Anger and shame are aspects that are specifically associated with psychopathology and maladaptation after childhood abuse and neglect. They are known to influence symptom maintenance and exacerbation; however, their interaction is not fully understood. Objective: To explore with network analysis the association and interaction of prolonged, complex interpersonal childhood abuse and neglect in institutional foster care settings [institutional abuse (IA)] with anger, shame, and the proposed 11th revision of the International Statistical Classification of Diseases and Related Health Problems (ICD-11) post-traumatic stress disorder (PTSD) symptoms in adult survivors. Method: Adult survivors of IA (N = 220, mean age = 57.95 years) participated in the study and were interviewed using the Childhood Trauma Questionnaire, the International Trauma Questionnaire, the State–Trait Anger Expression Inventory, the Displaced Aggression Questionnaire, and shame-related items. To identify the most central aspects, we used a staged network analysis and centrality analysis approach: (1) on the scale level; (2) on the item/symptom level; and (3) with modularity analysis to find communities within the item-level network. Results: Trait anger, anger rumination, emotional abuse, and PTSD re-experiencing symptoms played the most important roles on a scale level and were then further analyzed on the item/symptom level. The most central symptom on the item level was anger rumination related to meaningful past events. The modularity analysis supported discriminant validity of the included scales. Conclusions: Anger is an important factor in the psychopathological processes following childhood abuse. Anger rumination is closely related to PTSD symptoms; however, anger is not a part of the proposed ICD-11 PTSD in the present study.
Is obesity a favorable factor for resectability of rectal cancer?

BACKGROUND/AIMS It is well established that unresectable rectal tumors have a detrimental effect on long-term survival. Predictive factors for resectability focused on the body mass index and surgeon case volume were assessed in the present study. METHODOLOGY Data of 387 patients with rectal cancer and 284 patients with colon tumor who underwent elective surgical exploration during two periods (1986-1992 and 1994-2001) were evaluated. Univariate and multivariate analysis was performed to estimate the predictive factors for resectability of rectal cancer. The ratio of unresectable rectal and colon tumors was compared in subgroups of patients selected by body mass index. RESULTS The observed rate of resectability of rectal cancer was 78%. Coexisted distant metastases, low caseload of surgeons, body mass index < 25 kg/m2, tumor location < or = 12 cm and the first treatment period were associated with low rate of resectability. The ratio of unresectable tumors treated by surgeons with low case volume varied significantly with body mass index in rectal cancers (< 20 = 52%, 20-24.9 = 29%, 25-29.9 = 16%, > or = 30 = 19%) but not in colon tumors. CONCLUSIONS In respect to resectability of rectal cancer there was significant difference between surgeons with medium and low case volume. Patient's obesity seemed to be a favorable factor for resectability of tumors located in the rectum but not in the colon when operations were performed by surgeons with low case volume.
Gaucher disease: Identification of three new mutations in the Korean and Chinese (Taiwanese) populations

Gaucher Disease type 1, the most prevalent lysosomal disease among Caucasians, is due to defects in the activity of acid β‐glucosidase. Over 40 missense, nonsense, and more complex alleles have been described, primarily in Western populations. From these results, predictive genotype/phenotype correlations have been developed and used to guide genetic counseling and therapy. Only a few mutations have been described in Japanese patients with Gaucher disease and many of these have resulted in severe phenotypes. Although rare, Gaucher Disease occurs in Korean and Chinese (Taiwanese) populations. Sequencing of RT‐PCR cDNAs from five unrelated Korean and two sibling Chinese (Taiwanese) Gaucher type 1 patients identified three new Gaucher disease mutations. These disease alleles encoded V15L, G46E, and N188S substitutions leading to dysfunctional acid β‐glucosidases. The G46E was present in two Korean patients and the N188S allele was present in the Korean and Chinese (Taiwanese) populations, suggesting an ancient mutation. The commonality of these two mutations in the Korean and Chinese (Taiwanese) population indicates the need for more extensive screening for these mutations in the Gaucher populations. © 1996 Wiley‐Liss, Inc.
Placenta praevia at the Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife. A ten year analysis.

CONTEXT Placenta preavia is one of the obstetric emergencies associated with maternal mortality and morbidity. It is also a major cause ofprematurity. With prompt and appropriate management the complication can be drastically reduced. OBJECTIVE The objective of this study is to document the pattern of presentation, mode of management and the outcome of the management of placenta praevia at Obafemi Awolowo Teaching Hospitals Complex (I.H.U.), Ile-Ife between January, 1996 to December, 2005. The outcome will help in identifying the women at risk and offer suggestions to reduce the associated complications. MATERIALS AND METHODS The study involved a ten-year retrospective analysis of the data collected from the case records of all the cases diagnosed as having placenta praevia during the period under review. RESULTS During this period there were 7515 deliveries and a total of 128 cases of placenta praevia giving an incidence of 1.65% i.e. 3 in 200 births. Majority (58.2%) of patients with placenta praevia were unbooked and 77.4% of them were multiparous. Only 20.2% were accessible for diagnosis by ultrasound scanning, while 25.8% of them were delivered before 36 weeks of gestation. The perinatal mortality rate was 177 per 1000 births. CONCLUSION Placenta praevia is still a major cause of obstetric morbidity and mortality. The diagnosis can be made with routine ultrasound scanning which then allows patient identification and institution of appropriate and comprehensive treatment aimed at minimizing complications. The role of good referral system, 24 hours blood banking services and facilities for caesarean section and adequate neonatal backup in preventing morbidity and mortality associated with the condition can not be over emphasized.
Mitochondrial respiratory metabolism and performance of cattle.

Two groups of cows were sampled to study variation of mitochondrial metabolism. The first group included 10 lactating and five gestating Holstein cows, representing available phenotypic extremes for milk yield. The second group included 13 Angus, 13 Brangus and 13 Hereford cows, representing available extremes within breeds for growth breeding value ratios. Consistently poor mitochondrial samples were obtained from gestating cows; these were excluded from analyses. Linear correlations of Holstein mitochondrial respiratory activities with sire-predicted difference for milk and milk fat ranged from -. 35 to . 15. Correlations of dam and cow indices and cow yields for milk with acceptor-stimulated mitochondrial respiration, oxidative phosphorylation efficiency (adenosine diphosphate:oxygen ratio [ADP:O ratio]) and adenosine triphosphate (ATP) synthesis rate were . 25 to . 48, consistently higher than for milk fat, -. 06 to . 17. No differences among beef breeds in mitochondrial respiration rates, coupling of respiration to phosphorylation, ADP:O ratio or ATP synthesis rate were detected by repeated measures analyses of variance. No patterns were evident among correlations of the mitochondrial characteristics and growth and milk traits in beef cattle. These initial findings indicate that variability in the mitochondrial respiratory activities measured has less relation to weaning and yearling growth traits of beef cattle than to milk yield of Holstein cattle.
Some Facts on Incidence and Mortality of Cancer in Iran

1. Dept. of Social Medicine, School of Medicine, Dezful University of Medical Sciences, Dezful, Iran 2. Dept. of Epidemiology and Biostatistics, School of Public Health, Iran University of Medical Sciences, Tehran, Iran 3. Dept. of Public Health, Faculty of Health, Zabol University of Medical Sciences, Zabol, Iran 4. Dept. of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Implied Correlation and Market Returns

This paper provides evidence that the implied correlation is an indicator of market-wide risk. From a time-series approach, we analyze whether aggregate implied correlation contains information on future market returns. We document that it explains an important fraction of the variation in aggregate market excess returns, with high implied correlation inducing an increase in subsequent market returns. The predictive power is stronger at a forecast of quarterly and semi- annual return horizons and is not captured by standard predictors like valuation ratios and business cycle variables. Moreover, we show that the information con- tent of the correlation risk premium and realized correlation on market returns is fully driven by the implied correlation.
Long noncoding RNA UBE2R2-AS1 promotes glioma cell apoptosis via targeting the miR-877-3p/TLR4 axis

Introduction: Brain glioma is the most common type of primary malignancy in the central nervous system (CNS), with high recurrence and mortality rate, especially glioblastoma (GBM). Recent evidence suggests a role for many long noncoding RNAs (lncRNAs) in the pathogenesis, proliferation, apoptosis, metastasis, and chemotherapeutic resistance of cancer cells. Although the functions of some lncRNAs in the occurrence and development of gliomas have been confirmed, detailed mechanisms of action are lacking. Furthermore, the biological roles of many other lncRNAs in glioma have not been reported at all. Methods: In this study, we identified a novel lncRNA, UBE2R2-AS1, which was dramatically downregulated in glioma compared with normal tissue, by performing microarray detection of six pairs of glioma samples and adjacent normal tissues. In vitro experiments demonstrated that UBE2R2-AS1 regulated glioma cell proliferation, apoptosis, and migration. Results: UBE2R2-AS1 acted as a competing endogenous RNA (ceRNA) to target Toll-like receptor 4 (TLR4) mRNA by binding to miR-877-3p. Furthermore, lncRNA UBE2R2-AS1 suppressed glioblastoma cell growth, migration, and invasion, as well as promoting cell apoptosis by targeting miR-877-3p/TLR4 directly. Conclusion: This information regarding UBE2R2-AS1 and its glioma-related molecular mechanisms will aid the future identification of new lncRNA-directed diagnostics and drug-targeting therapies.