Miracle-dz/UniFAR-FTUs huggingface dataset:
Al Qaeda Strikes Back

AL QAEDA is a more dangerous enemy today than it has ever been before. It has suffered some setbacks since September n, zool: losing its state within a state in Afghanistan, having several of its top operatives killed, failing in its attempts to overthrow the governments of Egypt, Jordan, and Saudi Arabia. But thanks largely to Washington's eagerness to go into Iraq rather than concentrate on hunting down al Qaeda's leaders, the organization now has a solid base of operations in the badlands of Pakistan and an effective franchise in western Iraq. Its reach has spread throughout the Muslim world, where it has devel oped a large cadre of operatives, and in Europe, where it can claim the support of some disenfranchised Muslim locals and members of the Arab and Asian diasporas. Osama bin Laden has mounted a successful propaganda campaign to make himself and his movement the primary symbols of Islamic resistance worldwide. His ideas now attract more followers than ever. Bin Laden's goals remain the same, as does his basic strategy. He seeks to, as he puts it, "provoke and bait" the United States into "bleeding wars" throughout the Islamic world; he wants to bankrupt the country much as he helped bankrupt, he claims, the Soviet Union
Damage Maps of Veneered Zirconia under Simulated Mastication

Zirconia-based restorations often fracture from chipping and/or delamination of the porcelain veneers. We hypothesized that veneer chipping/delamination is a result of the propagation of near-contact-induced partial cone cracks on the occlusal surface under mastication. Masticatory loading involves the opposing tooth sliding along the cuspal inner incline surface with an applied biting force. To test this hypothesis, we cemented flat porcelain-veneered zirconia plates onto dental composites and cyclically loaded them (contact–slide–liftoff) at an inclination angle as a simplified model of zirconia-based restorations under occlusion. In light of in situ observation of damage evolution in a transparent glass/zirconia/polycarbonate trilayer, post mortem damage evaluation of porcelain/zirconia/composite trilayers by a sectioning technique revealed that deep-penetrating occlusal surface partial cone fracture is the predominant fracture mode of porcelain veneers. Clinical relevance is discussed.
Evaluation of Bleeding Events Requiring Hospitalization in Patients With Atrial Fibrillation Receiving Dabigatran, Warfarin, or Antiplatelet Therapy

Objective: To determine the incidence and severity of bleeding events requiring hospitalization among patients with atrial fibrillation (AF) receiving anticoagulants (dabigatran or warfarin) or antiplatelet agents (eg, aspirin and clopidogrel). Methods: This was a single-center, retrospective cohort study involving 1494 patients with AF hospitalized from November 1, 2010, to November 1, 2011, with prior warfarin, dabigatran, or antiplatelet therapy. Results: Overall bleeding events in the dabigatran group compared to the warfarin group were 24% and 12%, respectively (P = .004). Of these events, individually, there were no significant differences in major (56% vs 58%, P = .88), life-threatening (25% vs 36%, P = .38), or minor bleeding (44% vs 42%, P = .06). Gastrointestinal (GI) bleeding occurred more in the dabigatran group compared to the warfarin group (P = .02). Intracranial bleeding occurred in 15% of patients in the warfarin group and did not occur at all in the dabigatran group. Warfarin patients had significantly more overall bleeding events compared to antiplatelet therapy (P < .001), with an increasing trend seen in major bleeding (P = .06). GI bleeding, however, favored the warfarin group over the antiplatelet group (48% vs 73%, P = .04). Conclusion: Anticoagulation with dabigatran was associated with an overall increased occurrence of bleeding requiring hospital admission compared to warfarin. GI bleeding was more prevalent with dabigatran and antiplatelets than with warfarin. There were more intracranial hemorrhages seen in the warfarin group.
The allocation of prizes in crowdsourcing contests

A unique characteristic of crowdsourcing contest is the coexistence of multiple contests and each individual contestant strategically chooses the contest that maximizes his/her expected gain. The competition between contests for contestants significantly changes the optimal allocation of prizes for contest organizers. We show that the contestants with higher ability prefer to single-prize contests while those with lower ability prefer to multiple-prize contests, which makes single-prize contest is no longer the optimal choice for organizers as it was in the context of a single contest. We demonstrate that the organizers may allocate multiple prizes whether they intent to maximize total efforts or highest efforts, and presents the condition under which the multiple-prize approach will be optimal. Introduction With the growth of the internet and online communities, crowdsourcing has increasingly become an important strategy for businesses to tap into the wisdom of the public. Crowdsourcing refers to “the act of a company or institution taking a function once performed by employees and outsourcing it to an undefined (and generally large) network of people in the form of an open call. ” (Howe 2006). The function can be R&D challenges, product design, advertisement planning, software development and others. Crowdsourcers can be Fortune 500 companies, government agencies, charity organizations, or small enterprises and individuals, while crowdsourcees are typically small enterprises and individuals (Howe 2008). Crowdsourcing is often conducted in a form of contest with prize varying from hundreds to millions of dollars. In a crowdsourcing contest, a crowdsourcer announces a task contest and the associated prize rule, then the public decide whether to participate given the task requirement, his/her capability and prize rules. After the crowdsourcees complete the tasks and submit their results, the crowdsourcer chooses the winner(s) and award prize(s) based on the prize rule. One of the most well-known crowdsourcing contests is organized by Netflix, a movie rental company. It offers a prize of $1 million to the first contestant(s) who can improve its movie recommendation system by at least 10 percent. A central issue in the design of crowdsourcing contest is the allocation of prizes among contestants. Offering prizes to multiple contestants can encourage participation while offering a single prize to the best contestant can increase competition among the The 10th International Conference on Electronic Business, Shanghai, December 1 December 4, 2010 653
Balancing Arc Synthesis, mRNA Decay, and Proteasomal Degradation

Background: Muscarinic acetylcholine receptor (mAchR) activation enhances expression of Arc, a key gene for synaptic plasticity and memory. Results: Carbachol-evoked Arc expression is abruptly curtailed by translation-dependent RNA decay and proteasomal degradation. Conclusion: Short, rapid eye movement sleep-like, bursts of cholinergic activity induce maximal Arc expression. Significance: Cholinergic epoch pattern may be a critical determinant of Arc expression and function in synaptic plasticity and memory. Cholinergic signaling induces Arc/Arg3.1, an immediate early gene crucial for synaptic plasticity. However, the molecular mechanisms that dictate Arc mRNA and protein dynamics during and after cholinergic epochs are little understood. Using human SH-SY5Y neuroblastoma cells, we show that muscarinic cholinergic receptor (mAchR) stimulation triggers Arc synthesis, whereas translation-dependent RNA decay and proteasomal degradation strictly limit the amount and duration of Arc expression. Chronic application of the mAchR agonist, carbachol (Cch), induces Arc transcription via ERK signaling and release of calcium from IP3-sensitive stores. Arc translation requires ERK activation, but not changes in intracellular calcium. Proteasomal degradation of Arc (half-life ∼37 min) was enhanced by thapsigargin, an inhibitor of the endoplasmic calcium-ATPase pump. Similar mechanisms of Arc protein regulation were observed in cultured rat hippocampal slices. Functionally, we studied the impact of cholinergic epoch duration and temporal pattern on Arc protein expression. Acute Cch treatment (as short as 2 min) induces transient, moderate Arc expression, whereas continuous treatment of more than 30 min induces maximal expression, followed by rapid decline. Cholinergic activity associated with rapid eye movement sleep may function to facilitate long term synaptic plasticity and memory. Employing a paradigm designed to mimic intermittent rapid eye movement sleep epochs, we show that application of Cch in a series of short bursts generates persistent and maximal Arc protein expression. The results demonstrate dynamic, multifaceted control of Arc synthesis during mAchR signaling, and implicate cholinergic epoch duration and repetition as critical determinants of Arc expression and function in synaptic plasticity and behavior.
[Ovarian endometriomas: Effect of laparoscopic cystectomy on ovarian response in IVF-ET cycles].

OBJECTIVE To investigate the follicular response to controlled ovarian hyperstimulation (COH) in IVF-ET cycles after laparoscopic ovarian cystectomy for large endometriomas. PATIENTS AND METHODS In the set of a retrospective controlled study, the medical records of 113 infertile women who underwent IVF-ET cycles after laparoscopic surgery were reviewed. The study group (A) consisted of 63 patients with severe pelvic endometriosis and endometrioma excision. The control group (B) consisted of 50 infertile patients with mild or minimal endometriosis. Interventions were laparoscopic ovarian cystectomy in the study group, and COH in both groups. RESULTS Groups A and B were not different in terms of epidemiologic data. The total numbers of recruited follicles (9.1+/-3.3 vs 10.6+/-4.2; P = 0.001), mature follicles (> or =16 mm) (4.2+/-1.7 vs 4.8+/-2.2; P = 0.04), mature oocytes retrieved (5.8+/-3.8 vs 7.4+/-4.6; P = 0.02), and fertilization rate (48.9+/-34.9 vs 61.8+/-32.1%; P = 0.02) observed in group A were lower than those observed in group B, respectively. While the mean number of rFSH ampoules (75 IU) was increased in group A (38.1+/-20.4) compared to group B (29.3+/-16.4; P = 0.004), cumulative pregnancy rates were similar in both groups (27.5+/-8.8% vs 37.2+/-10.6%; P = 0.37). DISCUSSION AND CONCLUSIONS Ovarian response was reduced during IVF-ET cycles in patients with history of severe endometriosis and laparoscopic excision of endometriomas compared to women with mild or minimal endometriosis without ovarian surgery.
Office Market Segmentation in Emerging Markets: A Study of Sao Paulo

This study uses a unique dataset from Sao Paulo, Brazil, to investigate how corporate and smaller occupiers differ in their willingness to pay for principal office rent determinants. We partition our sample of buildings based on the average size of lease-able units to test whether rent premiums associated with property attributes, locational submarkets and economic change can be generalized or are localized to each group. Results from hedonic regressions show that corporate and smaller occupier properties form both spatial and non-spatial submarkets, but not in terms of temporal changes in market rent which are found to be highly correlated across office market segments. These findings suggest that these property-type segments can be classified as imperfect substitutes with distinct underlying pricing differences for building vintage, specification, size and location, but not as independent real estate markets.
Tenogenically Induced Allogeneic Peripheral Blood Mesenchymal Stem Cells in Allogeneic Platelet-Rich Plasma: 2-Year Follow-up after Tendon or Ligament Treatment in Horses

Poor healing of tendon and ligament lesions often results in early retirement of sport horses. Therefore, regenerative therapies are being explored as potentially promising treatment for these injuries. In this study, an intralesional injection was performed with allogeneic tenogenically induced mesenchymal stem cells and platelet-rich plasma 5–6 days after diagnosis of suspensory ligament (SL) (n = 68) or superficial digital flexor tendon (SDFT) (n = 36) lesion. Clinical, lameness and ultrasonographic evaluation was performed at 6 and 12 weeks. Moreover, a survey was performed 12 and 24 months after treatment to determine how many horses were competing at original level and how many were re-injured. At 6 weeks, 88.2% of SL (n = 68) and 97.3% of SDFT lesions (n = 36) demonstrated moderate ultrasonographic improvement. At 12 weeks, 93.1% of SL (n = 29) and 95.5% of SDFT lesions (n = 22) improved convincingly. Moreover, lameness was abolished in 78.6% of SL (n = 28) and 85.7% (n = 7) of SDFT horses at 12 weeks. After 12 months (n = 92), 11.8% of SL and 12.5% of SDFT horses were re-injured, whereas 83.8 of SL and 79.2% of SDFT returned to previous performance level. At 24 months (n = 89) after treatment, 82.4 (SL) and 85.7% (SDFT) of the horses returned to previous level of performance. A meta-analysis was performed on relevant published evidence evaluating re-injury 24 months after stem cell-based [17.6% of the SL and 14.3% of the SDFT group (n = 89)] versus conventional therapies. Cell therapies resulted in a significantly lower re-injury rate of 18% [95% confidence interval (CI), 0.11–0.25] 2 years after treatment compared to the 44% re-injury rate with conventional treatments (95% CI, 0.37–0.51) based on literature data (P < 0.0001).
A Strobilurin Fungicide Enhances the Resistance of Tobacco against Tobacco Mosaic Virus and Pseudomonas syringae pvtabaci 1

The strobilurin class of fungicides comprises a variety of synthetic plant-protecting compounds with broad-spectrum antifungal activity. In the present study, we demonstrate that a strobilurin fungicide, F 500 (Pyraclostrobin), enhances the resistance of tobacco (Nicotiana tabacum cv Xanthi nc) against infection by either tobacco mosaic virus (TMV) or the wildfire pathogenPseudomonas syringae pv tabaci. F 500 was also active at enhancing TMV resistance in NahGtransgenic tobacco plants unable to accumulate significant amounts of the endogenous inducer of enhanced disease resistance, salicylic acid (SA). This finding suggests that F 500 enhances TMV resistance in tobacco either by acting downstream of SA in the SA signaling mechanism or by functioning independently of SA. The latter assumption is the more likely because in infiltrated leaves, F 500 did not cause the accumulation of SA-inducible pathogenesis-related (PR)-1 proteins that often are used as conventional molecular markers for SA-induced disease resistance. However, accumulation of PR-1 proteins and the associated activation of the PR-1 genes were elicited upon TMV infection of tobacco leaves and both these responses were induced more rapidly in F 500-pretreated plants than in the water-pretreated controls. Taken together, our results suggest that F 500, in addition to exerting direct antifungal activity, may also protect plants by priming them for potentiated activation of subsequently pathogen-induced cellular defense responses.
Tablets and Tablet Apps: What Do Hotel Customers Want?

Abstract This study aims to explore consumers’ preference whether to bring their own tablets or use those provided by hotels, their expectations of hotel tablet apps, and antecedents of their behavioral intention toward hotel tablet apps. This study applied an extended model of the unified theory of acceptance and use of technology to understand consumers’ perceptions of tablet apps. By surveying 1,034 customers, this study found the respondents were more likely to utilize some tablet app features over others and revealed five key antecedents of customers’ behavioral intentions toward hotel tablet apps. The findings will help operators make informed decisions to maximize the benefits of tablet technology investments. The theoretical framework of this study provides a benchmark for other researchers to further investigate this field.
Action of major insecticide groups on insect cell lines of the beet armyworm, Spodoptera exigua, compared with larvicidal toxicity

SummaryIn a first series of experiments, the biological response of a continuous cell line of the beet armyworm, Spodoptera exigua, was tested with different groups, of insecticides with different modes of actions; acetylcholinesterase inhibitors, acetycholine receptor agonists, inhibitors and uncouplers of oxidative phosphorylation, site I electron transport inhibitors, gamma-aminobutyric acid receptor inhibitors, chitin synthesis inhibitors, and juvenile hormone analogues. From the concentration response curves, 50% inhibition concentration (IC50) values were calculated. The most active compound in vitro was pyridaben with an IC50 value of 0.0083 ppm. In a second series of experiments, the toxicity of these insecticide groups was determined on third-instar larvae of S. exigua, and lethal concentration with 50% kill (LC50) values were used in the evaluation of their in vivo biological activity. Toxicity bioassays showed that lufenuron was the most toxic (LC50=0.098 ppm). To explain the discrepancies in biological responses in vitro with insect cells compared with in vivo conditions with whole third-instar larvae, the significance of different detoxifying enzyme systems was tested. P450 monooxygenases, esterases, and glutathione S-transferases were measured in third-instar larvae and cells of S. exigua. Data are discussed in terms of the usefulness of insect cell cultures as tools in the screening for novel insecticide actions.
The haemodialysis machine as a lifeline: experiences of suffering from end-stage renal disease.

AIM The aim of this study was to describe patients' experiences of suffering from end-stage renal disease (ESRD). RATIONALE The rationale was to investigate how persons find meaning or make sense of their situation and how they experience suffering. The theoretical basis for the study was to view suffering at three levels. The first level was related to sickness and treatment. The second level was related to the care provided and the third level was related to each person's unique life experience and existence. METHOD Data were collected by interviews focusing on questions concerning daily life, needs, and expectations for the future. A qualitative interpretative content analysis was used. Fifteen patients between the ages of 50-86 participated in the study. FINDINGS Two main themes were identified describing these patients suffering. The first theme, 'the haemodialysis machine as a lifeline' consisted of three subthemes: 'loss of freedom', 'dependence on the caregiver', and 'disrupted marital, family and social life'. The second theme 'alleviation of suffering' consisted of two subthemes: 'gaining a sense of existential optimism' and 'achieving a sense of personal autonomy'. CONCLUSION This study indicated that, in the lives of patients on haemodialysis, the main areas of suffering were related to loss of freedom expressed as dependence on the haemodialysis machine as a lifeline and, the caregivers. This time-consuming and tiring dependence affected marital, family and social life. Alleviation of suffering could be achieved by accepting dependence on the haemodialysis machine and maintaining autonomy by being seen as an individual by the caregivers.
Platelet amyloid precursor protein abnormalities in mild cognitive impairment predict conversion to dementia of Alzheimer type: a 2-year follow-up study.

BACKGROUND Alteration of the amyloid precursor protein (APP) forms ratio has been described in the platelets of patients with dementia of Alzheimer type (DAT) and in a subset of subjects with mild cognitive impairment (MCI). OBJECTIVE To evaluate the potential role of the platelet APP forms ratio in predicting progression from MCI to DAT. DESIGN Thirty subjects with MCI underwent a clinical and neuropsychological examination and a determination of the platelet APP forms ratio. Subjects were followed up periodically for 2 years, and the progression to dementia was evaluated. SETTING Community population-based sample of patients admitted for memory complaints. RESULTS Patients who progressed to DAT at the 2-year follow-up (n = 12) showed a significant decrease of baseline platelet APP forms ratio values (mean +/- SD, 0.36 +/- 0.28) compared with stable MCI subjects (mean +/- SD, 0.73 +/- 0.32) (P<.01) and patients who developed other types of dementia (mean +/- SD, 0.83 +/- 0.27) (P =.03). By fixing a cutoff score of 0.6, 10 (83%) of the 12 DAT patients showed baseline values below the cutoff, whereas 10 (71%) of 14 subjects who either developed non-Alzheimer-type dementia or maintained cognitive functions had values in the normal range. CONCLUSION Mild cognitive impairment is a major risk factor for DAT, and Alzheimer disease-related pathological changes can be identified in patients converting to DAT within a 2-year follow-up.
Anomalies and News

Using a sample of 97 stock return anomalies documented in published studies, we find that anomaly returns are 7 times higher on earnings announcement days and 2 times higher on corporate news days. The effects are similar on both the long and short sides, and they survive adjustments for risk exposure and data mining. Moreover, anomaly signals predict errors in analysts’ earnings forecasts — analysts’ forecasts are systematically too low for anomaly-longs and too high for anomaly-shorts. Taken together, our results support the view that anomaly returns are the result of biased expectations, which are at least partially corrected upon news arrival.
Demand compliant design of robotic systems

The scarcity of methods for generating innovation systematically, quickly and without mistakes is felt across the technology intensive industries. An emerging autonomous robot industry produce the most complex artefacts ever made and stands to benefit most from effective design methods. In previous work, we described a framework for demand compliant design based on the existence of a demand catalogue and a method specific design database. In this paper, we show how to apply the method to an efficient exploration of design space starting a small and ill defined set of demands. Both the demand catalogue and design data are generated iteratively during the design process. We illustrate this process with the design of a hearing module for robots.