Miracle-dz/UniFAR-FTUs huggingface dataset:
Polymorphism of Listeria monocytogenes and Listeria innocua strains isolated from short‐ripened cheeses

Thirty isolates of Listeria monocytogenes and 18 of L. innocua obtained from different short‐ripened cheeses manufactured in Asturias (northern Spain), were compared with each other and with reference strains using serotype, phage type and pulsed‐field restriction endonuclease digestion profiles analysis of the total DNA. Restriction enzymes ApaI and SmaI defined five clusters in L. monocytogenes (m1 to m5) and two main clusters in L. innocua (i1 and i2). Cluster i2 was further arranged into three subclusters (i2a, i2b and i2c) based on the different Eco52I (XmaIII) and Crf42I (SacII) patterns of its isolates. Clusters of L. innocua were clearly different whereas those of L. monocytogenes were more closely related to each other. In this latter species, serotype 4b isolates (m4 and m5) constituted a more homogeneous group than serogroup 1 isolates (m1, m2 and m3). Cluster m3 contained two strains of serotype 1/2a whereas m1 and m2 harboured strains of both serotypes, 1/2a and 1/2b. Therefore, the combined use of restriction patterns and serotype may be useful to differentiate L. monocytogenes strains showing identical restriction profiles but differing in serotype. The cheese source of Listeria strains proved that isolates from cluster m1 were repeatedly detected as a contaminant in the same type of cheese. Comparison of L. monocytogenesApaI profiles showed a genetic proximity of m4 and m5 to the recognized pathogenic strains ATCC 13932 and NCTC 11994, responsible for meningitis cases in other countries. Finally, bacteriophage typing data indicated that m4, the sole phage typable group, had a phage type resembling that of strains causing the Auckland (New Zealand) outbreak of listeriosis in 1969. These data suggest a wide distribution of closely related types which might cause, under several circumstances, sporadic cases of listeriosis.
Anesthetic management of tongue reduction in a case of Beckwith-Wiedemann syndrome

Anesthesia for partial glossectomy in a premature child with Beckwith-Wiedemann syndrome presents as a unique challenge to the Anesthesiologist. Airway management in patients presenting with macroglossia is especially significant and requires meticulous preparation and pre-operative assessment. This report delineates the anesthetic concerns such as an anticipated difficult airway due to a large tongue, prematurity, hypoglycemia and an oral cavity surgery and their management.
Putting people first in obesity

Bias and discrimination against people with obesity create obstacles to quality patient care. Language used for this disease contributes to the problem. People-first language is the standard for respectfully addressing people with chronic disease, rather than labeling them by their illness. Because of the importance of reducing bias associated with obesity, The Obesity Society and all members of the Obesity Care Continuum have affirmed people-first language as the standard for their publications and programs.
ThingPot: an interactive Internet-of-Things honeypot

The Mirai Distributed Denial-of-Service (DDoS) attack exploited security vulnerabilities of Internet-of-Things (IoT) devices and thereby clearly signalled that attackers have IoT on their radar. Securing IoT is therefore imperative, but in order to do so it is crucial to understand the strategies of such attackers. For that purpose, in this paper, a novel IoT honeypot called ThingPot is proposed and deployed. Honeypot technology mimics devices that might be exploited by attackers and logs their behavior to detect and analyze the used attack vectors. ThingPot is the first of its kind, since it focuses not only on the IoT application protocols themselves, but on the whole IoT platform. A Proof-of-Concept is implemented with XMPP and a REST API, to mimic a Philips Hue smart lighting system. ThingPot has been deployed for 1.5 months and through the captured data we have found five types of attacks and attack vectors against smart devices. The ThingPot source code is made available as open source.
Cyclin‐Dependent Kinase Inhibitors for the Treatment of Breast Cancer: Past, Present, and Future

Treatment of metastatic breast cancer (MBC) that is resistant to endocrine therapy presents a significant clinical challenge. The well‐known role of cell cycle dysregulation in these patients is partly mediated by cyclin‐dependent kinase (CDK) activity. Specific cyclin and CDK complexes regulate cell cycle progression by managing the transition through the cell cycle, and inhibition of CDKs represents an important target for novel agents. First‐generation CDK inhibitors (e.g., flavopiridol) were relatively nonselective and had an unacceptable toxicity profile in early trials. Second‐generation CDK inhibitors were designed to target the CDK4 and CDK6 (CDK4/6) pathway and have shown promising clinical activity with an acceptable toxicity profile in patients with MBC. Palbociclib is a first‐in‐class CDK4/6 inhibitor that was granted accelerated U.S. Food and Drug Administration approval in combination with letrozole for the treatment of MBC in the first‐line setting (February 2015) as well as in combination with fulvestrant for MBC that had progressed on previous endocrine therapy (February 2016). Other CDK4/6 inhibitors, including ribociclib and abemaciclib, are under investigation as monotherapy and in combination with endocrine or anti–human epidermal growth receptor 2 therapy for the treatment of MBC. Ongoing clinical trials should provide additional information to guide the appropriate use of these agents and identify patient populations that could derive the most benefit.
Plus Ça Change: Selected Papers on Speech Research from the 1964 Issue of the Cleft Palate Journal

This review is part of a series of papers by the editorial board reflecting on the 1964 volume of the journal, thereby marking the 50th anniversary of the Cleft-Palate Craniofacial Journal. Twelve speech-related contributions from that year are reviewed. The papers are sorted into four broad thematic categories: quantitative assessment of hypernasality, perceptual assessment of speech, radiological imaging of velopharyngeal function, and speech prosthetics. The 1964 contributions are discussed with regards to their relevance to today's research and clinical practice.
Therapeutic modulation of epigenetic drivers of drug resistance in ovarian cancer

Epigenetic changes in tumours are associated not only with cancer development and progression, but also with resistance to chemotherapy. Aberrant DNA methylation at CpG islands and associated epigenetic silencing are observed during the acquisition of drug resistance. However, it remains unclear whether all of the observed changes are drivers of drug resistance, causally associated with response of tumours to chemotherapy, or are passenger events representing chance DNA methylation changes. Systematic approaches that link DNA methylation and expression with chemosensitivity will be required to identify key drivers. Such drivers will be important prognostic or predicitive biomarkers, both to existing chemotherapies, but also to epigenetic therapies used to modulate drug resistance.
Novel Corynebacterium diphtheriae in Domestic Cats

Novel nontoxigenic Corynebacterium diphtheriae was isolated from a domestic cat with severe otitis. Contact investigation and carrier study of human and animal contacts yielded 3 additional, identical isolates from cats, although no evidence of zoonotic transmission was identified. Molecular methods distinguished the feline isolates from known C. diphtheriae.
Transdermal delivery of butamben using elastic and conventional liposomes

Abstract Gel formulations containing the local anesthetic butamben (BTB) encapsulated in either conventional (BTBLUV) or elastic (BTBLUV-EL) liposomes were prepared and characterized, and then evaluated in terms of their skin permeability. Parameters measured included vesicle size and surface charge, BTB fluorescence anisotropy, encapsulation efficiency, partition coefficient and liposomal membrane organization. Encapsulation efficiencies and membrane/water partition coefficients were determined using a phase separation. The partition coefficients of the elastic and conventional formulations were 2025 ± 234 and 1136 ± 241, respectively. The sizes of the elastic and conventional liposomes did not change significantly (p > 0.05) following incorporation of the anesthetic. As expected, the elastic liposomes presented order parameters that were lower than those of the conventional liposomes, as determined by electron paramagnetic resonance with a 5-stearic acid nitroxide probe incorporated into the bilayer. After 8 h, the fluxes into the receiving solution (µg/cm2/h) were 6.95 ± 1.60 (10% BTB), 23.17 ± 6.09 (10% BTBLUV) and 29.93 ± 6.54 (10% BTBLUV-EL). The corresponding time lags (h) were 1.90 ± 0.48, 1.23 ± 0.28 and 1.57 ± 0.38, respectively. The permeability coefficients (10−3 cm/h) were 1.02 ± 0.23, 2.96 ± 0.77 and 4.14 ± 0.9, for 10% BTB, 10% BTBLUV and 10% BTBLUV-EL, respectively. The results demonstrate that anesthetic access through the skin can be considerably enhanced using liposomal gel formulations, compared to plain gel formulations.
Same or Different? Clarifying the Relationship of Need for Cognition to Personality and Intelligence

Need for cognition (NFC) refers to an individual’s tendency to engage in and enjoy effortful cognitive processing. So far, little attention has been paid to a systematic evaluation of the distinctiveness of NFC from traits with similar conceptualization and from intelligence. The present research contributes to filling this gap by examining the relation of NFC to well-established personality concepts (Study 1) and to a comprehensive measure of intelligence in a sample with broad educational backgrounds (Study 2). We observed NFC to be positively correlated with openness, emotional stability, and traits indicating goal orientation. Using confirmatory factor analysis and event-related potentials, incremental validity of NFC and openness to ideas was demonstrated, showing that NFC is more predictive of drive-related and goal-oriented behavior and attentional resource allocation. Regarding intelligence, NFC was more associated with fluid than with crystallized aspects of intelligence. Altogether, the results provide strong support for the conceptual autonomy of NFC.
Network-Based Data-Driven Filtering With Bounded Noises and Packet Dropouts

This paper is concerned with the problem of a network-based data-driven filter design for discrete-time linear systems with bounded noises and packet dropouts. One favorable feature is that the designed filter can be directly employed without identifying the unknown system model. To compensate the negative effects of packet dropouts, an output predictor is first designed to reconstruct the missing data based on the received outputs and the inputs of the system. The asymptotic convergence of the output prediction error is established, of which the rate can be adjusted by the parameter. Then utilizing the predicted outputs and the received measurements, an almost-optimal data-driven filter with tractability is proposed within the set membership (SM) framework and the bound on the worst case estimation error is derived. Finally, two illustrative examples, including a comparison example and an application example, are presented to show the advantages of the proposed design and the effectiveness of the theoretical results.
The effect of tibio-femoral traction mobilization on passive knee flexion motion impairment and pain: a case series

Abstract The purpose of this case series was to explore the effects of tibio-femoral (TF) manual traction on pain and passive range of motion (PROM) in individuals with unilateral motion impairment and pain in knee flexion. Thirteen participants volunteered for the study. All participants received 6 minutes of TF traction mobilization applied at end-range passive knee flexion. PROM measurements were taken before the intervention and after 2, 4, and 6 minutes of TF joint traction. Pain was measured using a visual analog scale with the TF joint at rest, at end-range passive knee flexion, during the application of joint traction, and immediately post-treatment. There were significant differences in PROM after 2 and 4 minutes of traction, with no significance noted after 4 minutes. A significant change in knee flexion of 25.9°, which exceeded the MDC95, was found when comparing PROM measurements pre- to final intervention. While pain did not change significantly over time, pain levels did change significantly during each treatment session. Pain significantly increased when the participant's knee was passively flexed to end range; it was reduced, although not significantly, during traction mobilization; and it significantly decreased following traction. This case series supports TF joint traction as a means of stretching shortened articular and periarticular tissues without increasing reported levels of pain during or after treatment. In addition, this is the first study documenting the temporal aspects of treatment effectiveness in motion restoration.
Structure and Biodistribution Relationships of Photodynamic Sensitizers *

Abstract— Photodynamic therapy (PDT) has, during the last quarter century, developed into a fully fledged biomedical field with its own association, the International Photodynamic Association (IPA) and regular conferences devoted solely to this topic. Recent approval of the first PDT sensitizer, Photofrin® (porfimer sodium), by health boards in Canada, Japan, the Netherlands and United States for use against certain types of solid tumors represents, perhaps, the single most significant indicator of the progress of PDT from a laboratory research concept to clinical reality.
Quality of Life Is Markedly Improved in Patients With Fecal Incontinence After Sacral Nerve Stimulation

Objective The aim of the present analysis was to report on the relationship between long-term improvement in quality of life (QOL) and fecal incontinence (FI) severity and long-term reduction in FI episodes after sacral nerve stimulation (SNS) or sacral neuromodulation. Methods Patients who met inclusion/exclusion criteria, and initially had more than 2 FI episodes per week, were offered SNS therapy. Patients with 50% or higher reduction in FI during a 2-week test period were implanted with a neurostimulator (InterStim; Medtronic, Minneapolis, Minn). Assessments were completed by patients at baseline and at 3, 6, and 12 months after implant, and annually thereafter. The present report includes data from the 4-year postimplant follow-up. Results A total of 133 patients underwent test stimulation with a 90% success rate, and as a result, 120 (110 females) with a mean age of 60.5 years and a mean duration of FI of 6.8 years received long-term implantation. Of them, 78 patients completed all or part of the 4-year follow-up assessment. Fecal incontinence episodes decreased from a mean of 9.4 per week at baseline to 1.9 per week at 48 months (P < 0.001). The 4-year analyses showed that SNS had a positive and sustained impact on all 4 scales of the Fecal Incontinence Quality of Life questionnaire (P < 0.001), Fecal Incontinence Severity Index scores improved from a mean of 39.9 to 28 (P < 0.001), and self-rated bowel health scores improved from a mean of 3.5 to 6.9 (P < 0.001). Conclusions Sacral nerve stimulation not only restores or improves continence in treated patients with chronic FI but also improves their quality of life and symptom severity.
A Research for Measuring Administrative Effectiveness

Abstract The purpose of this research is to develop an instrument for the evaluation of administrative effectiveness, by discussing the aspects of organizational effectiveness and organizational levels in a university. The sample of the research consisted of 203 academic personnel as the study group of the research. The results of the study indicated that university organizations can be evaluated through administrative effectiveness criteria that are developed by synthesizing four levels into organizational structure of the universities. The results of the study also showed that there is a fifth level at policy-strategy level and a study which is conducted without considering this aspect will be insufficient. The results also revealed that evaluation tool for administrative effectiveness which is developed to that end and be used in administrative effectiveness research and studies in universities.
Variable-rate variable-power non-coherent M-FSK scheme for power limited systems

In response to the ongoing demand for low power applications, the two first authors have recently proposed in F.F. Digham and M. -S. Alouini (2004) a discrete-modulation and fixed-power non-coherent M-ary frequency shift keying scheme. In this paper, we propose an extension of that work by studying a discrete-modulation and continuous-power (DMCP) scheme for further power saving over Nakagami fading channels. The modulation level and power assignment are selected in order to minimize the average transmitted power while meeting average spectral efficiency and bit error rate constraints. We further investigate the problem with an additional peak power constraint. In this case, the modulation switching thresholds are shifted to higher values yielding reduction in both the achievable average spectral efficiency and the average transmitted power. However, the power loading function can be re-shaped to maintain the same average power of transmission for the cases on no-peak and with-peak power constraints. This reshaping is designed so as to involve constant power portions which can be of interest from a practical stand point
In Their Own Words: How Family Carers of People with Dementia Understand Resilience

There is a growing body of research on resilience in family carers of people with dementia, but carers’ voices are noticeably absent from it. The aim of this study was to explore carers’ definitions of resilience and their opinions on the factors associated with resilience. Twenty-one in-depth interviews were conducted in Australia with people who were currently, or had previously been, caring for a family member with dementia. Transcripts were analysed thematically and three themes emerged: the presence of resilience, the path to resilience, and characteristics of the resilient carer. Although carers struggled to define resilience, the vast majority considered themselves resilient. Carers identified a range of traits, values, environments, resources, and behaviours associated with resilience, but there was no consensus on the relative importance or causal nature of these factors. Carers also considered resilience to be domain- and context-specific, but did not agree on whether resilience was a trait or a process. These findings highlight both the importance of including carers’ voices in resilience research and the limitations of the extant literature. There is much to be done to develop a field of carer resilience research that is theoretically sound, methodologically rigorous, and reflects the lived experience of carers. A model is provided to prompt future research.
Field Testing and Modeling of the Fenton-Filtration Process for Arsenic Removal

Abstract v Table of Abbreviations and Symbols vi Introduction 1 Jar Tests 2 Methods and Materials for Jar Tests 2 Results of Jar Tests 3 Reaction Pathways of the Fenton-Filtration Process 11 Methods and Materials for Fenton Stoichiometry Experiments 11 Results of Stoichiometry Experiments 12 Sorption Modeling 17 Arsenic Removal During Full-Scale Treatment Plant Operation 19 Results of Full-Scale Tests 19 Acknowledgments 23 References 25 Appendix 1. Data from Jar Tests 27
Two Cultures: Undergraduate Academic Engagement

Using data on upper-division students in the University of California system, we show that two distinct cultures of engagement exist on campus. The culture of engagement in the arts, humanities and social sciences focuses on interaction, participation, and interest in ideas. The culture of engagement in the natural sciences and engineering focuses on improvement of quantitative skills through collaborative study with an eye to rewards in the labor market. The two cultures of engagement are strongly associated with post-graduate degree plans. The findings raise questions about normative conceptions of good educational practices in so far as they are considered to be equally relevant to students in all higher education institutions and all major fields of study.
Thinking about brain cell assemblies.

Neurobiologists from Sherrington to Hebb (1 ) have struggled with the problem of how perception, cognition, and memory are coded by assemblies of neurons within the cerebral cortex of the brain. We can now simultaneously monitor the activity of hundreds of neighboring cells (2) and have identified functional properties of ensembles of neurons in the cortex and hippocampus (3-7). In this issue of Science, Wilson and McNauehton ( 8 ) reDort one of the . first of these studies on the hippocampus, a phylogenetically old part of the brain that is a final stage of information processing for some kinds of memory. They are able to monitor the activity of neural ensembles and show that, when it comes to functional coding, many neurons are better than one. These kinds of studies-plus insights from computational neuroscience-are beginning to show how the hierarchical organization of the cerebral cortex can be coupled with distributed coding. We may soon understand the nature of representation in the "thinking" parts of the brain. A comprehensive understanding of representation by neural ensembles will require reconciliation of two extreme views of information coding in the cortex. One view espouses a systematic organization com~osed of a hierarchv of "filters" or "detectors" that encode simple stimulus features and com~lex events bv the activitv of single neuron' (9). A cont;asting view'espouses a fully distributed representation that encodes each item by distinct spatiotemporal activity patterns of homogeneous arrays of neurons (1 0). These opposing views may in fact be reconcilable; in the brain, both are employed to different extents at successive stages of information processing (see fieure). ~viYdence in support of the idea that the brain codes information with feature detectors followed closely the development of the extracellular microelectrode in the late 1950s. This technology unexpectedly revealed that cortical firing patterns could readily be related to recognizable dimensions of stimuli and actions ( I I). Many such observations, perhaps most widely promoted by Hubel and Wiesel's studies on the visual cortex, revealed an organized topo-