Miracle-dz/UniFAR-FTUs huggingface dataset:
Peritoneal lavage cytology: an assessment of its value during prophylactic oophorectomy.

OBJECTIVE Prophylactic oophorectomy (PO) is an accepted treatment strategy for women who are at high risk for the development of ovarian carcinoma, particularly women who are BRCA mutation-positive. This study sought to assess the utility of peritoneal lavage cytology at the time of PO in detecting occult malignancy in this group of patients. METHODS Thirty-five high-risk women, who were not suspected of having any malignancy or ovarian mass, underwent peritoneal lavage at the time of PO. Thirty-one of the thirty-five women had undergone BRCA mutation analysis (BRCA1+, 18; BRCA2+, 10; BRCA-, 3). Intensive histopathologic examination was used in all 35 cases to identify occult carcinoma. Lavage specimens were reviewed for the presence of malignant cells and endosalpingiosis. The cytologic review was conducted without knowledge of either the histopathologic or BRCA results. RESULTS In 32 of the 35 lavage specimens no malignancy was detected. In the remaining three cases malignant cells were detected; in two of these cases histopathologic examination confirmed an ovarian/tubal occult carcinoma. Two of these women were BRCA1 mutation positive. Endosalpingiosis was detected in the peritoneal lavage specimens of 7 of the 32 cases showing no evidence of malignancy. All of these 7 women were BRCA mutation positive or unknown. CONCLUSION Peritoneal lavage cytology can detect occult carcinoma at the time of PO and should be performed at PO. The significance of occult carcinoma detected by either histopathologic or cytopathologic examination is uncertain. Whether the prevalence of endosalpingiosis detectable by lavage cytology is increased in BRCA mutation-positive patients requires further study.
Cognitive Bias and Paw Preference in the Domestic Dog (Canis familiaris)

Limb use, an indicator of hemispheric functioning, may be a useful predictor of cognitive bias and hence vulnerability to welfare risk. The relationship between cognitive bias and motor asymmetry, however, has been subject to little investigation. This study explored the association between motor asymmetry and cognitive bias in the domestic dog, a species that displays lateral bias in the form of paw preferences and exhibits positive and negative affective states. Thirty pet dogs had their paw preferences assessed using the Kong ball test. The subjects’ affective state was assessed using a cognitive bias test in which the animals’ latency to approach a bowl placed in 1 of 3 ambiguous positions was recorded. Animals veering more toward a left-paw preference were found to be significantly slower to approach the bowl placed in 1 of the ambiguous positions than ambilateral or right-pawed dogs. Left-pawed subjects approached the bowl located at the 3 ambiguous positions at roughly the same speed, while ambilateral and right-pawed animals became increasingly slower to approach the bowl the further it was located from the baited food bowl. The study points to a possible relationship between cognitive bias and paw preference in the dog, with left-pawed animals being more negative or “pessimistic” in their cognitive outlook than right-pawed or ambilateral individuals. It is proposed that limb preference testing might offer a more practical and straightforward way of identifying individuals at risk from poor welfare by virtue of how they perceive the world than more time-consuming cognitive bias tests.
Yes We Can (Price Derivatives on Survivor Indices)

We propose a simulation approach to value derivatives when the underlying dynamics are estimated using the survivor indices directly. Our results show that survivor forward and swap premiums increase with maturity and with the market price of risk. Our results also confirm that taking the optionality into consideration is important from a pricing perspective, for both U.S. women and men. We compare our results to what is obtained using an alternative modeling approach in which a Lee–Carter model is used to indirectly model the survivor index. Compared to this method, our estimated premiums and prices are higher for all longevity products. Moreover, comparing American-style with European-style options we find that, although the early exercise option has value when using survivor indices directly, the relative value of the early exercise option is significantly less than when the Lee–Carter model is used to indirectly model the survivor index. It follows that the assumed mortality dynamics have important implications for the term structure of forward and swap premiums and for the effect that changes in the market price of risk has on them.
About a MoirÉ-Less Condition for Non-Square Grids

The moire-less condition is found for non-square grids. The exact solution is found in form of a quartic equation depending on the geometric parameter. The root gives the optimal angle for minimized moires. The approximate solution is also found as well as the upper limit for residual moires. The proximity of the two solutions is proven. Experiments confirm the theoretical findings. The results can be used for minimizing moires in display devices which include several layers of regular grids.
Ökonomische Wirkungen der Handwerksnovelle 2004: Ergebnisse einer Kontrollgruppenanalyse

Zusammenfassung Die Reform der Handwerksordnung des Jahres 2004 brachte insbesondere durch die Abschaffung der Meisterpflicht für mehr als die Hälfte der Gewerbezweige des Handwerks eine umfassende Liberalisierung der Zugangsbedingungen. Der vorliegende Beitrag analysiert unter Verwendung von Daten des Zentralverbandes des Deutschen Handwerks (ZDH) den Einfluss der Handwerksnovelle auf die Anzahl der Betriebe und die Ausbildungsleistung in den betroffenen Handwerken. Die Wirkungen der Handwerksnovelle werden durch das Differenz-von-Differenzen-Verfahren geschätzt, das darauf aufbaut, dass nur ein Teil der Gewerbezweige des Handwerks von der Reform betroffen war. Die Ergebnisse zeigen einen starken Anstieg der Anzahl der Betriebe und einen Rückgang der absolvierten Meisterprüfungen in den betroffenen Handwerken in Folge der Reform. Bezüglich der Ausbildungsleistung werden jedoch keine statistisch signifikanten Effekte ermittelt. Umfangreiche Robustheitsanalysen bestätigen diese Ergebnisse.
The Toxicology of New Psychoactive Substances: Synthetic Cathinones and Phenylethylamines

Background: New psychoactive substances (NPSs) are substitutes for classical drugs of abuse and there are now compounds available from all groups of classical drugs of abuse. During 2014, the number of synthetic cathinones increased dramatically and, together with phenylethylamines, they dominate the NPS markets in the European Union. In total, 31 cathinones and 9 phenylethylamines were encountered in 2014. The aim of this article was to summarize the existing knowledge about the basic pharmacology, metabolism, and human toxicology of relevant synthetic cathinones and phenylethylamines. Compared with existing reviews, we have also compiled the existing case reports from both fatal and nonfatal intoxications. Methods: We performed a comprehensive literature search using bibliographic databases PubMed and Web of Science, complemented with Google Scholar. The focus of the literature search was on original articles, case reports, and previously published review articles published in 2014 or earlier. Results: The rapid increase of NPSs is a growing concern and sets new challenges not only for societies in drug prevention and legislation but also in clinical and forensic toxicology. In vivo and in vitro studies have demonstrated that the pharmacodynamic profile of cathinones is similar to that of other psychomotor stimulants. Metabolism studies show that cathinones and phenylethylamines are extensively metabolized; however, the parent compound is usually detectable in human urine. In vitro studies have shown that many cathinones and phenylethylamines are metabolized by CYP2D6 enzymes. This indicates that these drugs may have many possible drug-drug interactions and that genetic polymorphism may influence their toxicity. However, the clinical and toxicological relevance of CYP2D6 in adverse effects of cathinones and phenylethylamines is questionable, because these compounds are metabolized by other enzymes as well. The toxidromes commonly encountered after ingestion of cathinones and phenylethylamines are mainly of sympathomimetic and hallucinogenic character with a risk of excited delirium and life-threatening cardiovascular effects. Conclusions: The acute and chronic toxicity of many NPSs is unknown or very sparsely investigated. There is a need for evidence-based-treatment recommendations for acute intoxications and a demand for new strategies to analyze these compounds in clinical and forensic cases.
Top Users and Long Tails: Twitter and Instagram Use During the 2015 Norwegian Elections

Uses of social media for purposes of political campaigning have become widespread across several electoral contexts. However, as much of the research focused on these issues have dealt primarily with Twitter, relatively little is known regarding how parties make use of other, similar platforms. This article analyzes Twitter and Instagram use during the 2015 Norwegian elections. By adopting a comparative approach, the article suggests a novel approach for applying the often-used normalization and equalization hypotheses. While the former of these hypotheses suggests that larger parties will dominate online, the latter proposes that comparably smaller actors will utilize comparably novel services—such as Instagram in this case—to comparably larger extents than their more sizeable competitors. Contrary to the hypotheses, however, messages primarily relating to smaller actors tended to dominate on Twitter, while larger actors were found to be successful in terms of gaining traction on Instagram.
The phosphoinositol sphingolipids of Saccharomyces cerevisiae are highly localized in the plasma membrane

To investigate the vital function(s) of the phosphoinositol-containing sphingolipids of Saccharomyces cerevisiae, we measured their intracellular distribution and found these lipids to be highly localized in the plasma membrane. Sphingolipids were assayed in organelles which had been uniformly labeled with [3H]inositol or 32P and by chemical measurements of alkali-stable lipid P, of long chain bases, and of very long chain fatty acids. We have developed an improved method for the preparation of plasma membranes which is based on the procedure of Duran et al. (Proc. Natl. Acad. Sci. USA 72:3952-3955, 1975). On the basis of marker enzyme and DNA assays carried out with a number of preparations, the plasma membranes contained less than 10% vacuolar membranes (alpha-mannosidase) and nuclei (DNA); the contamination by the endoplasmic reticulum (NADPH-cytochrome c reductase) varied from 0 to 20%. The plasma membrane preparations showed a 13-fold increase in the specific activity of vanadate-sensitive ATPase, compared with that in the homogenate, with a yield ranging from 50 to 80%. A comparison of the distribution of the ATPase with that of sphingolipids assayed by a variety of methods showed that 80 to 100% of the sphingolipids are localized in the plasma membrane; the sphingolipids constitute about 30% of the total phospholipid content of the plasma membrane. Minor amounts of sphingolipids that were found in isolated mitochondria and nuclei can be attributed to the presence of small amounts of plasma membrane in these fractions. These results suggest that one or more essential functions of these lipids is in the plasma membrane. Furthermore, sphingolipids may be useful chemical markers of the plasma membrane of S. cerevisiae.
Murine Immunodeficiency Virus-Induced Peripheral Neuropathy and the Associated Cytokine Responses

Distal symmetrical polyneuropathy is the most common form of HIV infection-associated peripheral neuropathy and is often associated with pain. C57BL/6 (B6) mice infected with LP-BM5, a murine retroviral isolate, develop a severe immunodeficiency syndrome similar to that in humans infected with HIV-1, hence the term murine AIDS. We investigated the induction of peripheral neuropathy after LP-BM5 infection in B6 mice. Infected B6 mice, like HIV-infected humans, exhibited behavioral (increased sensitivity to mechanical and heat stimuli) and pathological (transient loss of intraepidermal nerve fibers) signs of peripheral neuropathy. The levels of viral gag RNA were significantly increased in all tissues tested, including spleen, paw skin, lumbar dorsal root ganglia, and lumbar spinal cord, postinfection (p.i.). Correlated with the development of peripheral neuropathy, the tissue levels of several cytokines, including IFN-γ, IL-1β, IL-6, and IL-12, were significantly elevated p.i. These increases had cytokine-specific and tissue-specific profiles and kinetics. Further, treatment with the antiretroviral agent zidovudine either significantly reduced or completely reversed the aforementioned behavioral, pathologic, and cytokine changes p.i. These data suggest that LP-BM5 infection is a potential mouse model of HIV-associated distal symmetrical polyneuropathy that can be used for investigating the roles of various cytokines in infection-induced neuropathic pain. Further investigation of this model could give a better understanding of, and lead to more effective treatments for, HIV infection-associated painful peripheral neuropathy.
Cross Sectional Analysis of Short Sale Determinants on U.S. Blue Chips

Short sale is a market practice that allows participle in overpricing markets. The fundamental goal of short sale is to sell borrowed securities, repurchase them back after their prices decrease and then return them to a lender. The aim of this paper is to investigate determinants of the short sale (measured by short sale ratio or SIR) activity. Based on the previous studies the short sale determinants are represented by market specific variables and fundamental-to-price ratios and correspond with hypotheses that explain investor motivations of going short. A panel regression with fixed effect is applied to determine these variables. The trend of short sale is analyzed by splitting the full sample period in three sub periods. There are identified factors such as abnormal rate of return, volume of trade, volatility, market capitalization and beta coefficient that are stable long term and influence the level of short sale. The results of fundamentals-to price ratio is not unambiguous and these variables do not considerably influence the level of short sale.
Comparative Effectiveness of Fish Oil Versus Fenofibrate, Gemfibrozil, and Atorvastatin on Lowering Triglyceride Levels Among HIV-Infected Patients in Routine Clinical Care

Objective:The goal of this study was to compare the effectiveness of fish oil, fenofibrate, gemfibrozil, and atorvastatin on reducing triglyceride (TG) levels among a large cohort of HIV-infected patients in clinical care. Design:Retrospective observational cohort study. Methods:The primary endpoint was absolute change in TG levels measured using the last TG value pretreatment and the first TG value posttreatment. A pre–post quasi-experimental design was used to estimate the change in TG because of initiating fish oil. Linear regression models examined the comparative effectiveness of treatment with fish oil versus gemfibrozil, fenofibrate, or atorvastatin for TG reduction. Models were adjusted for baseline differences in age, sex, race, CD4+ cell count, diabetes, body mass index, protease inhibitor use, and time between TG measures. Results:A total of 493 patients (mean age, 46 years; 95% male) were included (46 patients receiving gemfibrozil; 80, fenofibrate; 291, atorvastatin; and 76, fish oil) with a mean baseline TG of 347 mg/dL. New use of fish oil decreased TG [&Dgr;TG, −45 mg/dL; 95% confidence interval (CI): −80 to −11] in the pre–post study. Compared with fish oil (reference), fibrates were more effective (&Dgr;TG, −66; 95% CI: −120 to −12) in reducing TG levels, whereas atorvastatin was not (&Dgr;TG, −39; 95% CI: −86 to 9). Conclusions:In HIV-infected patients in routine clinical care, fish oil is less effective than fibrates (but not atorvastatin) at lowering TG values. Fish oil may still represent an attractive alternative for patients with moderately elevated TGs, particularly among patients who may not want or tolerate fibrates.
Model of the anaerobic metabolism of the biological phosphorus removal process: Stoichiometry and pH influence

In the anaerobic phase of a biological phosphorus removal process, acetate is taken up and converted to PHB utilizing both energy generated in the degradation of polyphosphate to phosphate, which is released, and energy generated in the conversion of glycogen to poly‐β‐hydroxy butyrate (PHB). The phosphate/acetate ratio cannot be considered a metabolic constant, because the energy requirement for the uptake of acetate is strongly influenced by the pH value. The observed phosphate/acetate ratio shows a variation of 0.25 to 0.75 P‐mol/C‐mol in a pH range of 5.5 to 8.5. It is shown that stored glycogen takes part in the metabolism to provide reduction equivalents and energy for the conversion of acetate to PHB. A structured metabolic model, based on glycogen as the source of the reduction equivalents in the anaerobic phase and the effect of the pH on the energy requirement of the uptake of acetate, is developed. The model explains the experimental results satisfactorily. © 1994 John Wiley & Sons, Inc.
Cost and Benefit of Apprenticeship Training

For the first time it has been made possible to merge a German and a Swiss firm-level data set that include detailed information about costs and benefits of apprenticeship training. Previous analyzes based only on aggregate data showed that the net costs of training apprentices are substantial in Germany, whereas apprenticeship training is on average profitable during the training period for firms in Switzerland, even though the two training systems are rather similar. This paper analyzes the reasons for these differences with matching methods. We simulate the impact of changes in certain parameters such as wages, apprenticeship systemrelated factors and allocation of tasks to apprentices on the cost-benefit ratio using the counterfactual values of the other country. The results show that most of the difference in the net costs of training between the two countries can be explained by a higher share of productive tasks allocated to apprentices in Switzerland and the differences in relative wages.
Unusual Distribution of Mutations Associated with Serial Bottleneck Passages of Human Immunodeficiency Virus Type 1

ABSTRACT Repeated bottleneck passages result in fitness losses of RNA viruses. In the case of human immunodeficiency virus type 1 (HIV-1), decreases in fitness after a limited number of plaque-to-plaque transfers in MT-4 cells were very drastic. Here we report an analysis of entire genomic nucleotide sequences of four HIV-1 clones derived from the same HIV-1 isolate and their low-fitness progeny following 7 to 15 plaque-to-plaque passages. Clones accumulated 4 to 28 mutations per genome, with dominance of A → G and G → A transitions (57% of all mutations) and 49% nonsynonymous replacements. One clone—but not three sibling clones—showed an overabundance of G → A transitions, evidencing the highly stochastic nature of some types of mutational bias. The distribution of mutations along the genome was very unusual in that mutation frequencies in gag were threefold higher than in env. Particularly striking was the complete absence of replacements in the V3 loop of gp120, confirmed with partial nucleotide sequences of additional HIV-1 clones subjected to repeated bottleneck passages. The analyses revealed several amino acid replacements that have not been previously recorded among natural HIV-1 isolates and illustrate how evolution of an RNA virus genome, with regard to constant and variable regions, can be profoundly modified by alterations in population dynamics.
Sunset jets observed on comet 67P/Churyumov-Gerasimenko sustained by subsurface thermal lag

We present observations of sunset jets on comet 67P/Churyumov-Gerasimenko by Rosetta/OSIRIS camera. In late April 2015, when the comet was at a heliocentric distance of ~1.8AU, clusters of dust jets that originated in the Ma’at region on the comet’s small lobe were identified from multipleimages and were apparently sustained for about an hour beyond local sunset. Emanating from the shadowed nucleus, these jets became visible by solar illumination at their apparent sources up to only a few tens of meters above the nucleus surface. We investigate the plausibility of these jets as having been triggered by water ice sublimation and sustained by thermal lag in the subsurface beyond sunset. A general thermo-physical model was parameterized such that the thermal lag in the subsurface is consistent with the elapsed time of observation after sunset. It is found that the sublimation of water ice from a depth of 6 mm and with a low thermal inertia of 50 W m-2 K-1 s1/2 could explain the spatial pattern and evolution of the apparent sources, particularly their disappearance due to the eventual cooling of the subsurface. Our analysis suggests that these sunset jets were essentially day-side dust activities that continued after sunset. Specific observational conditions for the sunset jets constrain their possible sources to mostly within the less abrupt, dusty terrains. The uneven distribution of these jets is possibly related to subsurface inhomogeneities in the dusty area.
Effect of host diversity and species assemblage composition on bovine tuberculosis (bTB) risk in Ethiopian cattle

SUMMARY Current theories on diversity–disease relationships describe host species diversity and species identity as important factors influencing disease risk, either diluting or amplifying disease prevalence in a community. Whereas the simple term ‘diversity’ embodies a set of animal community characteristics, it is not clear how different measures of species diversity are correlated with disease risk. We therefore tested the effects of species richness, Pielou's evenness and Shannon's diversity on bovine tuberculosis (bTB) risk in cattle in the Afar Region and Awash National Park between November 2013 and April 2015. We also analysed the identity effect of a particular species and the effect of host habitat use overlap on bTB risk. We used the comparative intradermal tuberculin test to assess the number of bTB-infected cattle. Our results suggested a dilution effect through species evenness. We found that the identity effect of greater kudu – a maintenance host – confounded the dilution effect of species diversity on bTB risk. bTB infection was positively correlated with habitat use overlap between greater kudu and cattle. Different diversity indices have to be considered together for assessing diversity–disease relationships, for understanding the underlying causal mechanisms. We posit that unpacking diversity metrics is also relevant for formulating disease control strategies to manage cattle in ecosystems characterized by seasonally limited resources and intense wildlife–livestock interactions.