Miracle-dz/UniFAR-FTUs huggingface dataset:
Kaolin clotting time and dilute Russell's viper venom time distinguish between prothrombin-dependent and beta 2-glycoprotein I-dependent antiphospholipid antibodies.

Antiphospholipid (aPL) antibodies include anticardiolipin (aCL) and lupus anticoagulant (LA) antibodies. LA antibodies recognize the complex of lipid-bound (human) prothrombin, in this way inhibiting the phospholipid-dependent coagulation reactions, whereas aCL antibodies are directed towards beta 2-glycoprotein I (beta 2-GPI) bound to an anionic lipid surface. According to their behavior in coagulation reactions, we have divided aCL antibodies into two groups: aCL-type A, which inhibit the phospholipid-dependent coagulation reactions because they enhance the binding of beta 2-GPI to the procoagulant phospholipid surface; and aCL-type B antibodies, which are devoid of anticoagulant properties. We report the distinctive laboratory and clinical profiles of 25 patients with well-characterized, phospholipid-dependent inhibitor of coagulation. Fourteen patients had LA antibodies (aCL-type B were concomitantly present in 10 cases, while in the other four, aCL titer was normal), and the other 11 had aCL-type A antibodies. The laboratory evaluation of the two groups showed the dilute Russell viper venom time (dRVVT) to be the most abnormal coagulation test in the aCL-type A-positive group, whereas the kaolin clotting time (KCT) was the most abnormal assay in the LA-positive group. In fact, the ratios of the coagulation times of patient plasma over normal pooled plasma (mean +/- standard deviation) for LA versus aCL-type A antibodies were 1.48 +/- 0.27 versus 2.20 +/- 0.42, P = . 0001, and 2.22 +/- 0.42 versus 1.50 +/- 0.42, P = . 0003, for the dRVVT and KCT, respectively. No differences were observed either in the ratios of the activated partial thromboplastin times and the prothrombin times or the plasma levels of beta 2-GPI and prothrombin. Conversely, aCL titers were significantly higher in aCL-type A-positive patients (147 +/- 44 U) than in the LA-positive group (61 +/- 55 U; P = .0003). We ruled out the possibility that platelet contamination of plasma could account for the observed coagulation profiles, as the two patterns were reproduced in platelet-free plasma. In addition, we performed clotting tests in plasma in the presence of phospholipids and calcium after addition of factor IXa or factor Xa. The assay performed with factor Xa was more sensitive to the presence of aCL-type A antibodies, while the assay performed with factor IXa was preferentially sensitive to LA-containing plasmas, supporting the earlier findings with the dRVVT and KCT assays. (ABSTRACT TRUNCATED AT 400 WORDS)
In vivo real-time 3-D intracardiac echo using PMUT arrays

Piezoelectric micromachined ultrasound transducer (PMUT) matrix arrays were fabricated containing novel through-silicon interconnects and integrated into intracardiac catheters for in vivo real-time 3-D imaging. PMUT arrays with rectangular apertures containing 256 and 512 active elements were fabricated and operated at 5 MHz. The arrays were bulk micromachined in silicon-on-insulator substrates, and contained flexural unimorph membranes comprising the device silicon, lead zirconate titanate (PZT), and electrode layers. Through-silicon interconnects were fabricated by depositing a thin-film conformal copper layer in the bulk micromachined via under each PMUT membrane and photolithographically patterning this copper layer on the back of the substrate to facilitate contact with the individually addressable matrix array elements. Cable assemblies containing insulated 45-AWG copper wires and a termination silicon substrate were thermocompression bonded to the PMUT substrate for signal wire interconnection to the PMUT array. Side-viewing 14-Fr catheters were fabricated and introduced through the femoral vein in an adult porcine model. Real-time 3-D images were acquired from the right atrium using a prototype ultrasound scanner. Full 60° × 60° volume sectors were obtained with penetration depth of 8 to 10 cm at frame rates of 26 to 31 volumes per second.
Using area-average remotely sensed surface soil moisture in multipatch land data assimilation systems

In coming years, Land Data Assimilation Systems (LDAS) two-dimensional (2-D) arrays of the relevant land-surface model) are likely to become the routine mechanism by which many predictive weather and climate models will be initiated. If this is so, it will be via assimilation into the LDAS that other data relevant to the land surface, such as remotely sensed estimates of soil moisture, will find value. This paper explores the potential for using low-resolution, remotely sensed observations of microwave brightness temperature to infer soil moisture in an LDAS with a "mosaic-patch" representation of land-surface heterogeneity, by coupling the land-surface model in the LDAS to a physically realistic microwave emission model. The past description of soil water movement by the LDAS is proposed as the most appropriate, LDAS-consistent basis for using remotely sensed estimates of surface soil moisture to infer soil moisture at depth, and the plausibility of this proposal is investigated. Three alternative methods are explored for partitioning soil moisture between modeled patches while altering the area-average soil moisture to correspond to the observed, pixel-average microwave brightness temperature, namely, 1) altering the soil moisture by a factor, which is the same for all the patches in the pixel, 2) altering the soil moisture by adding an amount that is the same for all the patches in the pixel, and 3) altering the change in soil moisture since the last assimilation cycle by a factor which is the same for all the patches in the pixel.
Patient satisfaction with triage nursing care in Hong Kong.

AIM This paper reports a study to examine the relationship between patient satisfaction and triage nursing care in order to assist nurses in defining more clearly their roles, and ultimately to improve the quality of care delivered to emergency patients. BACKGROUND Patient satisfaction is considered an important indicator of quality care from the perspective of the consumer and has been widely studied in many settings. However, few studies have examined patient satisfaction with emergency nursing services in the particular area of triage. METHODS A descriptive, correlational study was conducted in 2001 in one urban acute hospital in Hong Kong using Consumer Emergency Care Satisfaction Scale (CECSS), and patient and nurse demographic data were also collected. Following a power calculation, systematic sampling was carried out, and the final sample consisted of 56 urgent, semi-urgent and non-urgent patients triaged. The response rate was 61%. RESULTS The majority of the participants were satisfied with their triage nursing care and teaching. However, difficulties were encountered during the data collection process, resulting in a relatively low response rate. Correlational analyses revealed that patient satisfaction with triage nursing care was statistically significantly correlated with age and the type of nursing intervention received. Older people were more satisfied with the teaching offered by triage nurses and patients who had received specific nursing interventions gave more positive ratings on the teaching subscale of the CECSS. There were no statistically significant relationships between patient satisfaction with triage nursing care and nurse characteristics, including gender, work experiences and educational level. CONCLUSIONS Patients were generally satisfied with the care provided by the triage nurses. Measuring patient satisfaction with triage nursing care remains a major challenge for health care providers in emergency care settings.
s oropharyngeal colonization upon admission at a pediatric intensive care unit *

Objectives: This study aimed to identify the microbiological oropharyngeal colonization pattern in children admitted at a Pediatric Intensive Care Unit (PICU) and to verify the influence of childrens and implemented therapies characteristics before admission at the UCIP on this pattern. Prospective study realized at a PICU of a university hospital. Methods: Samples of oropharyngeal secretion were obtained in the first 24 hours of the childrens admission. Variables related to the childrens and the therapies characteristics were investigated. Results: The majority of the children had normal nutritional state, admitted in the hospital in emergencies situations, with chronic diseases and without alterations in the clinical conditions of the oral cavity. Conclusion: The children who were colonized by pathogenic microorganisms presented a longer hospital stay (p=0,020) than those with cultures with normal flora species. The investigated characteristics of the children did not exert any significant influence the microbiological oropharyngeal colonization pattern.
Searching the Web of Things

Technological advances allow more physical objects to connect to the Internet and provide their services on the Web as resources. Search engines are the key to fully utilize this emerging Web of Things, as they bridge users and applications with resources needed for their operation. Developing these systems is a challenging and diverse endeavor due to the diversity of Web of Things resources that they work with. Each combination of resources in query resolution process requires a different type of search engine with its own technical challenges and usage scenarios. This diversity complicates both the development of new systems and assessment of the state of the art. In this article, we present a systematic survey on Web of Things Search Engines (WoTSE), focusing on the diversity in forms of these systems. We collect and analyze over 200 related academic works to build a flexible conceptual model for WoTSE. We develop an analytical framework on this model to review the development of the field and its current status, reflected by 30 representative works in the area. We conclude our survey with a discussion on open issues to bridge the gap between the existing progress and an ideal WoTSE.
Acute promyelocytic leukemia in patients aged 70 years and over—A single center experience of unselected patients

The optimal management of patients over age 70 with acute myeloid leukemia (AML) is unclear. Aggressive treatment in such individuals is associated with a higher incidence of morbidity and inferior survival compared with their younger counterparts [1 – 3]. Thus, the identification of a subset of elderly patients who would benefit from intensive therapy is important. Acute promyelocytic leukemia (APL) is a subcategory of AML characterized by t(15;17), which results in synthesis of a PML-RARa fusion protein. Therapy with all-trans retinoic acid (ATRA) combined with anthracycline-based chemotherapy is associated with a 90 – 95% complete remission (CR) rate and a 70 – 80% 5-year disease free survival in younger patients [4]. APL in the elderly is rare, with around 5% occurring in individuals older than 70 years of age [5]. Several reports have indicated that treatment of APL is feasible in elderly patients, with long-term survivals in the 50 – 65% range [6 – 9]. However, these series have included a predominance of patients aged 60 – 70 years, and although patients4 age 70 were included, the degree of patient selection in these studies is unclear. In addition, toxicity data in these reports have been scarce. We retrospectively evaluated all APL patients aged 70 years seen at Princess Margaret Hospital, Toronto, Canada, from 1999 to 2006. The diagnosis was made by morphology and/or cytogenetics, and confirmed by molecular analysis of PML/RARa transcript by real time PCR (qRT-PCR). Baseline left ventricular function was measured both before and after chemotherapy either by multigated cardiac blood pool (MUGA) scan or echocardiography. The treatment regimens used are summarized in Table I. Induction therapy consisted of ATRA 45 mg/m per day in two divided doses for 28 days, combined with daunorubicin 45 or 60 mg/m intravenously daily for 3 days, according to medical discretion. Cytarabine 100 mg/m day as a 7-day continuous intravenous infusion (CIVI) was also given during induction prior to December 2000. For patients achieving CR, two cycles of consolidation therapy were given, each consisting of ATRA 45 mg/m per day for 28 days plus daunorubicin 45 – 60 mg/m daily 63; cytarabine 100 mg/m per day CIVI6 7 days was also used prior to December 2000. In patients with impaired left ventricular function, amsacrine (AMSA) 125 mg/m per day for 3 days was substituted for daunorubicin. One patient received induction with ATRA alone due to his frail medical status. Maintenance therapy consisted of ATRA 45 mg/m per day for 7/14 days for 9 months. 6-Mercaptopurine 50 mg/m per day for 3/4 weeks and Methotrexate 20 mg/m per week were added to the maintenance schedule in one patient because of leukocytosis at presentation. Hematologic CR was defined as the presence of normal bone marrow cellularity with 55%
ZINC AND ZINC TRANSPORTERS IN NORMAL PROSTATE FUNCTION AND THE PATHOGENESIS OF PROSTATE CANCER

Zinc is an essential metal for all cells. It plays a role in a wide variety of physiological and biochemical processes. In the prostate epithelial cell the accumulation of high cellular zinc is a specialized function that is necessary for these cells to carry out the major physiological functions of production and secretion of citrate. The production of citrate and its secretion into prostatic fluid is a differentiated function of the prostate epithelial cells that is apparently important for reproduction. The loss of citrate and zinc accumulation is the most consistent and persistent characteristic of prostate malignancy. This characteristic of prostate cancer indicates that the lost ability of the malignant cells to accumulate zinc and citrate is an important factor in the development and progression of malignancy. The lost ability of the epithelial cells to accumulate zinc and thus to also accumulate citrate is the result of decreased expression of specific zinc uptake transporters. The purpose of this presentation is to review the current understanding of zinc and zinc homeostasis in the prostate and the role of zinc and zinc transporters in the normal function of the prostate and the pathogenesis of prostate cancer.
Dynamic Functional Segregation and Integration in Human Brain Network During Complex Tasks

The analysis of the topology and organization of brain networks is known to greatly benefit from network measures in graph theory. However, to evaluate dynamic changes of brain functional connectivity, more sophisticated quantitative metrics characterizing temporal evolution of brain topological features are required. To simplify conversion of time-varying brain connectivity to a static graph representation is straightforward but the procedure loses temporal information that could be critical in understanding the brain functions. To extend the understandings of functional segregation and integration to a dynamic fashion, we recommend dynamic graph metrics to characterise temporal changes of topological features of brain networks. This study investigated functional segregation and integration of brain networks over time by dynamic graph metrics derived from EEG signals during an experimental protocol: performance of complex flight simulation tasks with multiple levels of difficulty. We modelled time-varying brain functional connectivity as multi-layer networks, in which each layer models brain connectivity at time window $t+\Delta t$ . Dynamic graph metrics were calculated to quantify temporal and topological properties of the network. Results show that brain networks under the performance of complex tasks reveal a dynamic small-world architecture with a number of frequently connected nodes or hubs, which supports the balance of information segregation and integration in brain over time. The results also show that greater cognitive workloads caused by more difficult tasks induced a more globally efficient but less clustered dynamic small-world functional network. Our study illustrates that task-related changes of functional brain network segregation and integration can be characterized by dynamic graph metrics.
Full‐length Cloning, Expression and Cellular Localization of Rat Plasmolipin mRNA, a Proteolipid of PNS and CNS

We have isolated a 1.476 bp cDNA (NTII11) representing a transcript that is differentially expressed during sciatic nerve development and regeneration in the rat. Nucleotide sequence comparison indicates partial identity with a recently isolated plasmolipin cDNA. However, our clone extends the published sequence by 234 bp at the 5’end and predicts a protein that contains an additional 25 amino acids at the N‐terminus. The open reading frame of the NTII11 transcript encodes a 19.4 kDa protein with four putative transmembrane domains. Northern blot analyses revealed a tissue‐specific expression of the plasmolipin transcript that is restricted to sciatic nerve, brain and kidney. The neural expression was confirmed by in situ hybridization, and cellular localization of plasmolipin mRNA was demonstrated in Schwann cells of the sciatic nerve and in glial cells of myelinated brain structures. The steady‐state levels of plasmolipin mRNA were markedly altered (i) during development of the sciatic nerve and brain, (ii) after sciatic nerve injury, and (iii) in cultured Schwann cells maintained under different conditions of cell growth and arrest. Our data indicate a function of plasmolipin during myelination in the central as well as in the peripheral nervous system.
The Kabachnik–Fields Reaction: Mechanism and Synthetic Use

The Kabachnik–Fields (phospha-Mannich) reaction involving the condensation of primary or secondary amines, oxo compounds (aldehydes and ketones) and >P(O)H species, especially dialkyl phosphites, represents a good choice for the synthesis of α-aminophosphonates that are of significant importance due to their biological activity. In general, these three-component reactions may take place via an imine or an α-hydroxy-phosphonate intermediate. The monitoring of a few Kabachnik–Fields reactions by in situ Fourier transform IR spectroscopy has indicated the involvement of the imine intermediate that was also justified by theoretical calculations. The Kabachnik–Fields reaction was extended to >P(O)H species, comprising cyclic phosphites, acyclic and cyclic H-phosphinates, as well as secondary phosphine oxides. On the other hand, heterocyclic amines were also used to prepare new α-amino phosphonic, phosphinic and phosphine oxide derivatives. In most cases, the synthesis under solvent-free microwave (MW) conditions is the method of choice. It was proved that, in the cases studied by us, there was no need for the use of any catalyst. Moreover, it can be said that sophisticated and environmentally unfriendly catalysts suggested are completely unnecessary under MW conditions. Finally, the double Kabachnik–Fields reaction has made available bis(phosphonomethyl)amines, bis(phosphinoxidomethyl)amines and related species. The bis(phosphinoxidomethyl)amines serve as precursors for bisphosphines that furnish ring platinum complexes on reaction with dichlorodibenzonitriloplatinum.
Adaptation of the Dartmouth COOP Charts for Use Among American Indian People With Diabetes

OBJECTIVE To adapt the Dartmouth COOP Charts for use among American Indians with diabetes and to evaluate the operating characteristics of the adapted charts because measures of health status have not been evaluated for use among American Indians with diabetes. RESEARCH DESIGN AND METHODS American Indian adults participated in focus group conferences to adapt and review the Dartmouth COOP Charts for use in American Indian communities. American Indian participants with diabetes were interviewed and administered the adapted charts. The operating characteristics of the charts were evaluated by measuring internal and external consistency, reliability, and acceptability. RESULTS Some of the wording and pictures were considered to be offensive and culturally inappropriate in American Indian communities. The adapted charts showed internal consistency in a comparison of interchart variables. CONCLUSIONS The adapted Dartmouth COOP Charts are more culturally acceptable than the original charts and appear to measure constructs adequately.
Induction of Protective Immunity against Japanese Encephalitis in Mice by Immunization with a Plasmid Encoding Japanese Encephalitis Virus Premembrane and Envelope Genes

ABSTRACT A DNA vaccine plasmid containing the Japanese encephalitis (JE) virus premembrane (prM) and envelope (E) genes (designated pcDNA3JEME) was evaluated for immunogenicity and protective efficacy in mice. Two immunizations of 4-week-old female ICR mice with pcDNA3JEME by intramuscular or intradermal injections at a dose of 10 or 100 μg per mouse elicited neutralizing (NEUT) antibodies at titers of 1:10 to 1:20 (90% plaque reduction), and all immunized mice survived a challenge with 10,000 50% lethal doses of the P3 strain of JE virus. A single immunization with 100 μg of pcDNA3JEME did not elicit detectable NEUT antibodies but induced protective immunity. Spleen cells obtained from BALB/c mice immunized once with 10 or 100 μg of pcDNA3JEME contained JE virus-specific memory cytotoxic T lymphocytes (CTLs). BALB/c mice maintained detectable levels of memory B cells and CTLs for at least 6 months after one immunization with pcDNA3JEME at a dose of 100 μg. The CTLs induced in BALB/c mice immunized twice with 100 μg of pcDNA3JEME were CD8 positive and recognized mainly the envelope protein. These results indicate that pcDNA3JEME has the ability to induce a protective immune response which includes JE virus-specific antibodies and CTLs.
Artin’s conjecture for representations of octahedral type

Let L/F be a finite Galois extension of number fields. E. Artin conjectured that the Z-series of a nontrivial irreducible complex representation of Gal(L/F) is entire, and proved this for monomial representations. The nonmonomial two-dimensional representations are those with image in PGL(2, C) isomorphic to the group of rigid motions of the tetrahedron, octahedron or icosahedron. In [5] Langlands proved Artin's conjecture for all two-dimensional representations of tetrahedral type and certain octahedral representations when F = Q. The purpose of this note is to prove the conjecture for all octahedral representations by using the methods of Langlands and an analytic result of Jacquet, Piatetskii-Shapiro and Shalika. Let p be an irreducible two-dimensional complex representation of Gal(Z,/F). We say that a cuspidal automorphic representation TT of GL(2, AF) equals 7r(p) if n =®TTV with irv = ir(pv) in the sense of [2, §12] for almost all places v of F. When n = 7r(p) the Z-series of TT and p agree, and since cuspidal representations have entire //-series, Artin's conjecture follows. In [5, §3] Langlands used base change for GL(2) to produce candidates for 7r(p). When p is octahedral we will use the following result to show that one of Langlands' candidates is in fact 7r(p).