Miracle-dz/UniFAR-FTUs huggingface dataset:
Can We Derive Explicit and Implicit Bias from Corpus?

Language is a popular resource to mine speakers' attitude bias, supposing that speakers' statements represent their bias on concepts. However, psychology studies show that people's explicit bias in statements can be different from their implicit bias in mind. Although both explicit and implicit bias are useful for different applications, current automatic techniques do not distinguish them. Inspired by psychological measurements of explicit and implicit bias, we develop an automatic language-based technique to reproduce psychological measurements on large population. By connecting each psychological measurement with the statements containing the certain combination of special words, we derive explicit and implicit bias by understanding the sentiment of corresponding category of statements. Extensive experiments on English and Chinese serious media (Wikipedia) and non-serious media (social media) show that our method successfully reproduce the small-scale psychological observations on large population and achieve new findings.
Conservation of Critical Functional Domains in Murine Plasminogen Activator Inhibitor-1*

Plasminogen activator inhibitor-1 is the main physiological regulator of tissue-type plasminogen activator in normal plasma. In addition to its critical function in fibrinolysis, plasminogen activator inhibitor-1 has been implicated in roles in other physiological and pathophysiological processes. To investigate structure-function aspects of mouse plasminogen activator inhibitor-1, the recombinant protein was expressed in Escherichia coli and purified. Five variant recombinant murine proteins (R76E, Q123K, R346A, R101A, and Q123K/R101A) were also generated using site-directed mutagenesis. The variant (R346A) was found to be defective in its inhibitory activity against tissue plasminogen activator relative to its wild-type counterpart. Enzyme-linked immunosorbent assay and surface plasmon resonance experiments demonstrated reduced vitronectin-binding affinity of the (Q123K) variant (KD = 1800 nm) relative to the wild-type protein (KD = 5.4 nm). Kinetic analyses indicated that the (Q123K) variant had a slower association (kon = 2.92 × 104 m-1 s-1) to, and a faster dissociation from, vitronectin (koff = 5.3 × 10-2 s-1), (wild-type kon = 1.03 × 106 m-1 s-1 and koff = 5.27 × 10-3 s-1). The Q123K/R101A variant demonstrated an even lower vitronectin-binding ability. Low density lipoprotein receptor-related protein binding was decreased for the (R76E) variant. It was also demonstrated that the plasminogen activator inhibitor-1/vitronectin complex decreased the interaction of plasminogen activator inhibitor-1 with low density lipoprotein receptor-related protein. These results indicate that the complex interactions traditionally associated with different plasminogen activator inhibitor-1 functions apply to the murine system, thus showing a commonality of subtle functions among different species and evolutionary conservation of this protein. Further, this study provides additional evidence that the human hemostasis system can be studied effectively in the mouse, which is a great asset for investigations with gene-altered mice.
Isolation-Aware Timing Analysis and Design Space Exploration for Predictable and Composable Many-Core Systems

Composable many-core systems enable the independent development and analysis of applications which will be executed on a shared platform where the mix of concurrently executed applications may change dynamically at run time. For each individual application, an off-line Design Space Exploration (DSE) is performed to compute several mapping alternatives on the platform, offering Pareto-optimal trade-offs in terms of real-time guarantees, resource usage, etc. At run time, one mapping is then chosen to launch the application on demand. In this context, to enable an independent analysis of each individual application at design time, so-called inter-application isolation schemes are applied which specify temporal or spatial isolation policies between applications. S.o. t.a. composable many-core systems are developed based on a fixed isolation scheme that is exclusively applied to every resource in every mapping of every application and use a timing analysis tailored to that isolation scheme to derive timing guarantees for each mapping. A fixed isolation scheme, however, heavily restricts the explored space of solutions and can, therefore, lead to suboptimality. Lifting this restriction necessitates a timing analysis that is applicable to mappings with an arbitrary mix of isolation schemes on different resources. To address this issue, we present an isolation-aware timing analysis that unlike existing analyses can handle multiple isolation schemes in combination within one mapping and delivers safe yet tight timing bounds by identifying and excluding interference scenarios that can never happen under the given combination of isolation schemes. Based on the timing analysis, we present a DSE which explores the choices of isolation scheme per resource within each mapping. Experimental results demonstrate the advantage of the proposed approach over approaches based on a fixed isolation scheme.
Administration of the PARP Inhibitor Pj34 Ameliorates the Impaired Vascular Function Associated With Enos−/− Mice

A low-resistance/high-flow uteroplacental circulation is integral to a healthy pregnancy. Impaired flow in the uterine circulation is associated with intrauterine growth restriction (IUGR) and preeclampsia (PE). Poly(ADP-ribose) polymerase (PARP) is a nuclear enzyme which has been associated with oxidative stress-induced vascular dysfunction. Using the endothelial nitric oxide synthase (eNOS−/ −) knockout mouse model, which features vascular dysfunction and IUGR, we tested the hypothesis that administration of a PARP inhibitor may ameliorate the vascular dysfunction associated with the eNOS−/− model. eNOS−/− animals were characterized by impaired uterine artery function when compared to controls. Administration of the PARP inhibitor PJ34 prevented this dysfunction. Gestational day (GD) 17.5 eNOS−/− mice did not exhibit altered systolic blood pressure when compared to control mice. However, treatment of eNOS−/− mice with PJ34 significantly reduced systolic blood pressure when compared to vehicle-treated eNOS−/−. Administration of a PARP inhibitor protects uterine artery function in the face of eNOS−/− deficiency.
The role of platform moderators in software crowdsourcing projects

Crowdsourcing divides a task into small pieces that are carried out by the crowd. In Software Engineering, crowdsourcing divides the software development tasks of to be carried out online by the crowd and is simply called Software Crowdsourcing (SW CS). The goal of this paper is to investigate the role of platform moderators in the communication process during SW CS projects. The findings indicate the relevant role of the platforms moderators in facilitating communication during competitions. Our results contribute to the discussion on how communication paths can be useful in information transfer among crowd and platform.
Spotting Collusive Behaviour of Online Fraud Groups in Customer Reviews

Online reviews play a crucial role in deciding the quality before purchasing any product. Unfortunately, spammers often take advantage of online review forums by writing fraud reviews to promote/demote certain products. It may turn out to be more detrimental when such spammers collude and collectively inject spam reviews as they can take complete control of users’ sentiment due to the volume of fraud reviews they inject. Group spam detection is thus more challenging than individual-level fraud detection due to unclear definition of a group, variation of inter-group dynamics, scarcity of labeled group-level spam data, etc. Here, we propose DeFrauder, an unsupervised method to detect online fraud reviewer groups. It first detects candidate fraud groups by leveraging the underlying product review graph and incorporating several behavioral signals which model multi-faceted collaboration among reviews. It then maps reviewers into an embedding space and assigns a spam score to each group such that groups comprising spammers with highly similar behavioral traits achieve high spam score. While comparing with five baselines on four real-world datasets (two of them were curated by us), DeFrauder shows superior performance by outperforming the best baseline with 17.64% higher NDCG@50 (on average) across datasets.
Catalysis by Supported Gold Nanoclusters

The physical and chemical properties of supported Au clusters are markedly sensitive to cluster size and morphology. To investigate the origin of the unique properties of nanosized Au clusters, model catalysts consisting of Au clusters of varying sizes have been prepared on single crystal TiO2(110) and ultrathin films of single crystalline TiO2, SiO2, and Al2O3. The morphology, electronic structure, and catalytic properties of these supported Au clusters have been investigated using an array of surface analytical techniques with particular emphasis to the unique properties of clusters <5.0 nm in size. These studies illustrate the novel and unique physical and chemical properties of nanosized supported metal clusters.
Psychotic phenomena in 257 young children and adolescents with bipolar I disorder: delusions and hallucinations (benign and pathological).

OBJECTIVES In contrast to studies of adult bipolar I disorder (BP-I), there is a paucity of data on psychotic phenomena in child BP-I. Therefore, the aim of this work was to describe delusions and hallucinations in pediatric BP-I. METHODS Subjects were 257 participants, aged 6-16, in either of two large, ongoing, NIMH-funded studies, 'Phenomenology and Course of Pediatric Bipolar Disorders' or 'Treatment of Early Age Mania (TEAM)'. All subjects had current DSM-IV BP-I (manic or mixed phase) with a Children's Global Assessment Scale score <or=60 (definite clinical impairment), and all had cardinal mania symptoms (i.e., elation and/or grandiosity). Comprehensive assessments included the Washington University in St. Louis Kiddie Schedule for Affective Disorders and Schizophrenia (WASH-U-KSADS), which was administered to parents about their children and separately to children about themselves by experienced research clinicians. The WASH-U-KSADS contains modules for developmentally child-age-specific manifestations of numerous categories of psychotic phenomena. RESULTS Psychosis was present in 76.3% (n = 196) of subjects, which included 38.9% (n = 100) with delusions, 5.1% (n = 13) with pathological hallucinations, and 32.3% (n = 83) with both. The most common delusion was grandiose (67.7%, n = 174), and the most common pathological hallucination was visual (16.0%, n = 41). Benign hallucinations occurred in 43.6% (n = 112). A median split by age yielded 6-9 year-olds (n = 139) and 10-16 year-olds (n = 118). Analyses of these two groups, and of 6, 7, 8, and 9 year-olds separately, found no significant differences in psychotic phenomena. CONCLUSIONS Counterintuitively, psychosis was equally prevalent in 6-9 compared to 10-16 year-olds. High prevalence of psychosis in child BP-I warrants focus in intervention strategies and is consistent with increasing evidence of the severity of child-versus adult-onset BP-I.
Carbamazepine in Fabry's disease

Seven patients with Fabry's disease and severe pain received carbamazepine (CMZ). Five of 7 patients had moderate to complete relief baaed upon self-assessment of pain levels. Preexisting autonomic dysfunction was exacerbated by CMZ in 2. Complications encountered were ileus, urinary retention, and gastrointestinal disturbance. Although CMZ was useful in treatment of pain, caution should be employed in this disease.
Serum anti-Müllerian hormone dynamics during controlled ovarian hyperstimulation.

BACKGROUND The study aim was to investigate possible changes in serum anti-Müllerian hormone (AMH) levels during controlled ovarian hyperstimulation (COH), and their possible relationship with follicular development and other ovarian hormones. METHODS A total of 93 women undergoing COH with GnRH agonist and FSH was studied prospectively. Serum levels of AMH, inhibin B, estradiol (E(2)), progesterone, testosterone and Delta(4)-androstenedione were measured when pituitary suppression was achieved (baseline), on days 6 and 8 of FSH treatment, and on the day of hCG. The number of small (<12 mm) and large (>/=12 mm) antral follicles were estimated using ultrasound. RESULTS Serum AMH levels declined progressively (baseline, 1.21 +/- 0.11 ng/ml; day 6, 0.91 +/- 0.09 ng/ml; day 8, 0.77 +/- 0.08 ng/ml; and day of hCG, 0.53 +/- 0.06 ng/ml), whereas-as expected-the other hormone levels increased during FSH treatment. Throughout COH, serum AMH levels correlated positively with the number of small but not large antral follicles, and with inhibin B serum levels. No correlation between AMH and the other hormones was observed. CONCLUSIONS Serum AMH levels decline gradually during multiple follicular maturation, probably reflecting the dramatic reduction in the number of small antral follicles due to COH, and confirming the scarce AMH expression by larger follicles.
Functional Communication Within a Perceptual Network Processing Letters and Pseudoletters

Summary Many studies have identified regions within human ventral visual stream to be important for object identification and categorization; however, knowledge of how perceptual information is communicated within the visual network is still limited. Current theories posit that if a high correspondence between incoming sensory information and internal representations exists, then the object is rapidly identified, and if there is not, then the object requires extra detailed processing. Event-related responses from the present magnetoencephalography study showed two main effects. The N1m peak latencies were approximately 15 milliseconds earlier to familiar letters than to unfamiliar pseudoletters, and the N2m was more negative to pseudoletters than to letters. Event-related beamforming analyses identified these effects to be within bilateral visual cortices with a right lateralization for the N2m effect. Furthermore, functional connectivity analyses revealed that gamma-band (50–80 Hz) oscillatory phase synchronizations among occipital regions were greater to letters than to pseudoletters (around 85 milliseconds). However, during a later time interval between 245 and 375 milliseconds, pseudoletters elicited greater gamma-band phase synchronizations among a more distributed occipital network than did letters. These findings indicate that familiar object processing begins by at least 85 milliseconds, which could represent an initial match to an internal template. In addition, unfamiliar object processing persisted longer than that for familiar objects, which could reflect greater attention to inexperienced objects to determine their identity and/or to consolidate a new template to aid in future identification.
Multiple schwannomas and meningiomas associated with irradiation in childhood.

OBJECTIVE To determine the pattern of neural tumors (schwannomas, vestibular schwannomas [acoustic neuromas], and meningiomas) that developed in 3013 people who received radiation treatment with x-ray beam therapy for benign conditions of the head and neck area before their 16th birthday. METHODS The surgical and pathology reports and pathology slides were reviewed for all neural tumors in the cohort. Patients with more than 1 neural tumor were compared with those with 1 neural tumor and those with no neural tumors. RESULTS There were 7 patients with multiple neural tumors and 63 with single neural tumors. The distribution of tumors in these 2 groups differed. The group with multiple tumors had more spinal nerve root schwannomas, while the group with single tumors had more cranial nerve schwannomas. Six of the 7 patients did not meet the diagnostic criteria for neurofibromatosis type 2. CONCLUSIONS Our findings suggest that host factors that increase susceptibility to radiation may be involved in the development of the multiple neural tumors. Clinically, patients with multiple neural tumors who do not meet the diagnostic criteria for neurofibromatosis type 2 should be questioned about radiation exposure. If exposure is confirmed, then screening for other radiation-related tumors should be initiated.
Methadone binding to human plasma proteins

The interaction of L‐(1‐3H) methadone with solutions of purified human gamma globulin and with human plasma was studied by equilibrium dialysis. The per cent of methadone bound to gamma globulin was dependent on drug and protein concentration. In the normal range of serum gamma globulin concentration and the therapeutic range of plasma methadone concentration, gamma globulin bound 13.4% to 17.4% ot the total drug concentration. The binding of methadone to plasma from 2 healthy male volunteers, nontolerant to narcotic analgesics, was dependent on drug concentration. Methadone bound to plasma proteins decreased from 87.3% to 83.7% as drug concentration increased in the therapeutic range. This small decrease is most likely due to decreased binding by the gamma globulin fraction since albumin binding is constant in this range. The data in this study, as weil as a previous study with albumin, suggest that methadone may also bind to other plasma proteins such as beta, alpha‐I, and alpha‐2 globulins.
CD14‐dependent and ‐independent cytokine and chemokine production by human THP‐1 monocytes stimulated by Streptococcus suis capsular type 2

Streptococcus suis capsular type 2 is an important aetiologic agent of swine meningitis, and it has been highlighted as a cause of occupational disease leading to meningitis and fulminant sepsis in humans. The objective of the present work was to study the ability of S. suis type 2 to induce the release of tumour necrosis factor alpha (TNF‐α), interleukin‐1 (IL‐1), IL‐6, IL‐8 and monocyte chemotactic protein one (MCP‐1) by human monocytic THP‐1 cells. The induction of these five cytokines was dose‐ and incubation time‐dependent, and it was significantly enhanced by pre‐treatment of cells with interferon gamma. IL‐8 levels were markedly higher compared with those obtained with the other cytokines. However, elevated levels of MCP‐1 and IL‐6 were also observed. Levels of cytokine induced by heat‐killed or live bacteria were similar. Pre‐treatment of cells with anti‐CD14 monoclonal antibodies suggested that this important host receptor is partially implicated in TNF, IL‐1, IL‐6 and MCP‐1 production, while CD14‐independent pathways seem to be responsible for IL‐8 production after S. suis stimulation. In addition, blocking studies with anti‐TNF and anti‐IL‐1 antibodies revealed that these cytokines are involved in amplification of the S. suis‐induced cytokine cascade. When several different S. suis strains of human or porcine origin were compared, a very heterogeneous pattern of cytokine production was observed. Human strains did not exhibit a clear tendency to induce higher cytokine release by human THP‐1 monocytes. The synergistic effect of the up‐regulation of cytokines during S. suis meningitis may mediate many of the inflammatory reactions, including the sequestration of leucocytes at the site of infection.
English Only (EO) In The Classroom: Time For a Reality Check?

The approach of using only English when teaching English as prescribed by the seventh curriculum has become a major issue in the debate over how to improve Korean students' communicative abilities in the L2. Discussions have not always been pleasant about the need to shake up the education system by different means, including using much more classroom English. (Fracas over Education, 2001). That the EO question, at times, has been framed in "all or nothing" views has appeared to take away from a common sense approach. There may be a more middle ground area, at least as a point of departure towards meeting the requirements of the new curriculum.
Demonstration of 184 and 255-GHz Amplifiers Using InP HBT Technology

In this letter, 184 and 255 GHz single-stage heterojunction bipolar transistor (HBT) amplifiers are reported. Each amplifier uses a single-emitter 0.4 ¿m 15 ¿m InP HBT device with maximum frequency of oscillation (fmax) greater than 500 GHz and of 200 GHz. The 183 GHz single-stage amplifier has demonstrated gain of 4.3 ± 0.4 dB for all sites on the wafer. The 255 GHz amplifier has measured gain of 3.5d B and demonstrates the highest frequency measured HBT amplifier gain reported to date. Both amplifiers show excellent agreement with original simulation.
Anatomical Predilection of Intestinal Metaplasia Based on 78,335 Endoscopic Cases

Background/Aims: Gastric intestinal metaplasia (IM) is an important risk factor for intestinal-type gastric carcinoma, and successful treatment critically depends on its timely detection. In order to guide appropriate endoscopic surveillance, objective knowledge on the anatomical predilection of intestinal metaplasia development is urgently needed. Materials and Methods: A total of 78,335 cases who underwent gastroduodenoscopy from 2008 to 2013 in Jiangsu and Anhui provinces in China, were studied. Demographic and clinical characteristics, as well as biopsy location and histological results, were analyzed. Results: This study revealed that intestinal metaplasia incidence was 28.5% in angulus, 20.24% in lesser curvature of the antrum, and 25.48% in corpus; and all these were significantly higher than those observed in other sites (P < 0.01). Histological grading of intestinal metaplasia in the lesser curvature of the antrum and angulus was generally worse than the grading observed in the greater curvature of the antrum. For Helicobacter pylori-positive patients, acute inflammation was more severe in the lesser curvature of the antrum compared with the greater curvature. In the H. Pylori-negative group, both acute and chronic inflammations were more severe in the lesser curvature of the antrum. Conclusions: The angulus, lesser curvature in the antrum, and corpus are most prone to the development of intestinal metaplasia. Inflammation is most severe in the lesser curvature of the antrum, which corresponds to a higher predilection to develop intestinal metaplasia at this site. The lesser curvature of the antrum and corpus require the most attention during endoscopic biopsy surveillance.
An Advanced Home Energy Management System Facilitated by Nonintrusive Load Monitoring With Automated Multiobjective Power Scheduling

Nowadays, electricity energy demands requested from down-stream sectors in a smart grid constantly increase. One way to meet those demands is use of home energy management systems (HEMS). By effectively scheduling major household appliances in response to demand response (DR) schemes, residents can save their electricity bills. In this paper, an advanced HEMS facilitated by a nonintrusive load monitoring (NILM) technique with an automated nondominated sorting genetic algorithm-II (NSGA-II)-based multiobjective in-home power scheduling mechanism is proposed. The NILM as an electricity audit is able to nonintrusively estimate power consumed by each of monitored major household appliances at a certain period of time. Data identified by the NILM are very useful for DR implementation. For DR implementation, the NSGA-II-based multiobjective in-home power scheduling mechanism autonomously and meta-heuristically schedules monitored and enrolled major household appliances without user intervention. It is based on an analysis of the NILM with historical data with past trends. The experimental results reported in this paper reveal that the proposed advanced HEMS with the NILM assessed in a real-house environment with uncertainties is workable and feasible.