Miracle-dz/UniFAR-FTUs huggingface dataset:
Nurse Staffing Models, Nursing Hours, and Patient Safety Outcomes

Background Data Limited research has been conducted examining the effect of nurse staffing models on costs and patient outcomes. Objective The objective of this study was to evaluate the effect of different nurse staffing models on costs and the patient outcomes of patient falls, medication errors, wound infections, and urinary tract infections. Methods A descriptive correlational study was conducted in all of the 19 teaching hospitals in Ontario, Canada. The sample comprised hospitals and adult medical, surgical, and obstetric inpatients within those hospitals. Results The lower the proportion of professional nursing staff employed on a unit, the higher the number of medication errors and wound infections. The less experienced the nurse, the higher the number of wound infections. Nurse staffing models that included a lower proportion of professional nursing staff in the mix used more nursing hours in this study. Conclusions The results of this study suggest that a higher proportion of professional nurses in the staff mix (RNs/RPNs) on medical and surgical units in Ontario teaching hospitals are associated with lower rates of medication errors and wound infections. Higher patient complexity was associated with greater patient use of nursing care resources.
An Examination of Factors that Influence Employees’ Behavioral Intention to Use Electronic Revenue Collection System in Public Hospitals

The aim of this paper is to examine the factors that influence the behavioural intention of Nigerian federal hospitals employees to use the e-collection system. Three factors (Perceived Usefulness, Perceived Ease of Use and Computer Self-efficacy) were considered in determining the behavioural intention of the employee to use the system. In achieving this, survey questionnaire instrument was used in collecting data from 72 e-collection users in some selected federal government hospitals. Smart Partial Least Square (PLS) 2.0 was used to analyze the data from the responses and the findings from the analysis revealed that all the three factors (Perceived Usefulness and Perceived Ease of Use and Computer Self-efficacy) are significant in influencing employees’ intention to use the ecollection system. As such, it is hopeful that the result of this paper will provide an understanding of the underlying factors that influence public sector employees to use new technology in the workplace which will equally provide government with the information on the necessary areas to improve so as to foster its electronic government initiatives in the country.
Clostridium difficile Infection: A Rarity in Patients Receiving Chronic Antibiotic Treatment for Crohn's Disease

Background:Prolonged antibiotic use is limited by several adverse effects, one of which is Clostridium difficile infection (CDI). The aim of this study was to determine the incidence of CDI in patients receiving chronic antibiotic treatment for Crohn's disease (CD). Methods:We conducted a retrospective review of 100 patients with CD for which ≥6 months of outpatient antibiotic therapy was prescribed. Data were collected regarding demographics, CD phenotype, treatment history, and CDI. The incidence of CDI in our patient population was calculated and compared with historical controls. Results:100 patients were studied—60% of men, mean age 23.9 years at CD diagnosis. Eighty-two percent had disease involving the ileum, and 33% had disease involving the colon. The mean duration of antibiotic therapy was 39.6 months (range, 6–217 months). The most commonly prescribed classes of antibiotics were fluoroquinolones (84%), penicillins (57%), and cephalosporins (32%). Forty-nine percent of patients were treated with concomitant thiopurines, 45% with budesonide, and 41% with biologics. The overall incidence of CDI was 2%. This incidence of CDI was lower than previously reported for non-CD patients receiving chronic antibiotics for continuous-flow left ventricular assist device infections (12.5%) and orthopedic prosthesis infections (22.2%). Conclusions:The incidence of CDI is rare in patients receiving chronic antibiotic treatment for CD, and it seems significantly lower than for non-CD populations reported in the literature.
Forecasting sales in industrial services: Modeling business potential with installed base information

Purpose The purpose of this paper is to examine how installed base information could help servitizing original equipment manufacturers (OEMs) forecast and support their industrial service sales, and thus increase OEMs’ understanding regarding the dynamics of their customers lifetime values (CLVs). Design/methodology/approach This work constitutes a constructive research aiming to arrive at a practically relevant, yet scientific model. It involves a case study that employs statistical methods to analyze real-life quantitative data about sales and the global installed base. Findings The study introduces a forecasting model for industrial service sales, which considers the characteristics of the installed base and predicts the number of active customers and their yearly volume. The forecasting model performs well compared to other approaches (Croston’s method) suitable for similar data. However, reliable results require comprehensive, up-to-date information about the installed base. Research limitations/implications The study contributes to the servitization literature by introducing a new method for utilizing installed base information and, thus, a novel approach for improving business profitability. Practical implications OEMs can use the forecasting model to predict the demand for – and measure the performance of – their industrial services. To-the-point predictions can help OEMs organize field services and service production effectively and identify potential customers, thus managing their CLV accordingly. At the same time, the findings imply new requirements for managing the installed base information among the OEMs, to understand and realize the industrial service business potential. However, the results have their limitations concerning the design and use of the statistical model in comparison with alternative approaches. Originality/value The study presents a unique method for employing installed base information to manage the CLV and supplement the servitization literature.
Balanced wide band fan-shaped three-tranducer SAW filters with reduced insertion loss and improved frequency response

This paper presents the new balanced SAW filters using fan-shaped IDTs with reduced insertion loss, a fractional bandwidth of 10-24% on 128°YX LiNbO3. The fan-shaped three-transducer structure containing one input IDT and two output IDTs with the split electrodes is used in these filters. The constructional and topological optimization of the SAW filters is provided with a computer simulation using an δ-function model. The 255, 305 MHz samples of the SAW filters have shown 3-dB bandwidth of 30-61 MHz, insertion loss of 5.5-7.5 dB, passband ripple of around 3 dB, shape factor of 1.28-1.5, stopband attenuation over 40 dB in a matched system. The samples were housed in the 5×5×1.35 mm SMD packages and could operate in balanced/unbalanced 50-Ω system.
Efficacies of Albendazole Sulfoxide and Albendazole Sulfone against In Vitro-Cultivated Echinococcus multilocularis Metacestodes

ABSTRACT The metacestode stage of Echinococcus multilocularis is the causative agent of alveolar echinococcosis (AE), a parasitic disease affecting the liver, with occasional metastasis into other organs. Benzimidazole carbamate derivatives such as mebendazole and albendazole are currently used for chemotherapeutic treatment of AE. Albendazole is poorly resorbed and is metabolically converted to its main metabolite albendazole sulfoxide, which is believed to be the active component, and further to albendazole sulfone. Chemotherapy with albendazole has been shown to have a parasitostatic rather than a parasitocidal effect; it is not effective in all cases, and the recurrence rate is rather high once chemotherapy is stopped. Thus, development of new means of chemotherapy of AE is needed. This could include modifications of benzimidazoles and elucidiation of the respective biological pathways. In this study we performed in vitro drug treatment of E. multilocularis metacestodes with albendazole sulfoxide and albendazole sulfone. High-performance liquid chromatography analysis of vesicle fluids showed that the drugs were taken up rapidly by the parasite. Transmission electron microscopic investigation of parasite tissues and nuclear magnetic resonance spectroscopy of vesicle fluids demonstrated that albendazole sulfoxide and albendazole sulfone had similar effects with respect to parasite ultrastructure and changes in metabolites in vesicle fluids. This study shows that the in vitro cultivation model presented here provides an ideal first-round test system for screening of antiparasite drugs.
Humanitarian health project supply chain costs

ABSTRACT The combination of inadequate health systems and the occurrence of humanitarian crisis results in significant logistics and supply chain management (LSCM) challenges in the support of their vulnerable populations. Because of the high cost of humanitarian LSCM and the limited funding available, it is important that organizations make the most of their limited resources. The aim of this research is to develop our understanding of the drivers of LSCM cost in a humanitarian setting. The paper explores the importance of a range of different underpinning potential factors impacting the cost per beneficiary and develops a resultant set of hypotheses tested with a robust regression model. The results demonstrate that the number of beneficiaries and the type of organization, the country’s gross domestic product (GDP) per capita, and the type of health programme all affect the supply chain costs per beneficiary. This research helps further the understanding of the drivers of efficiency for humanitarian supply chains and the impact of health programme design on supply chain costs.
[Evaluation of risk].

Th e aim of this study was to examine the eff ects of hypoglycaemic drug-agonists of PPAR-gama recep- tors-rosiglitazone (Avandia, mg - Glaxo Smith Kline) on values of wide-spread risk-markers: fi brinogen, C-reactive protein and uric acid and glicolysated haemoglobin HbAC as parameter of metabolic control. We examined forty patients who satisfi ed criteria for metabolic syndrome and distributed them into groups of diabetic and prediabetic patients according to criteria of IDF (International Diabetic Federa- tion). Th ese risk markers and glicolysated haemoglobin HbAC were observed at the beginning of therapy, then four, eight and twelve weeks into therapy and results were compared and statistically processed. Th ree months initial therapy with rosiglitazone signifi cantly reduced values of HbAC, fi brinogen and CRP but not uric acid in prediabetic patients. Rosiglitazone initial three months therapy signifi cantly reduced HbAC, fi brinogen and uric acid, but not CRP in diabetic patients.
Residents’ Perceived Marine Tourism Impacts and Support Development Attitude - Case Study of Jibei Island

This study analyzes a small island residents’ impact on development of marine tourism perception and support attitude to new island tourism development and investigates tourism dependence on residents’ impact perception and attitude toward support its moderating effect. This study took residents living on Jibei Island in Taiwan’s Penghu Islands archipelago as the subjects, using the convenience sampling method of questionnaires, and collected a total of 279 valid questionnaires. After statistical analysis, this study has the following findings. Residents perceived that tourism development has brought about the impact of traffic congestion, marine pollution, coastal landscape damage, destruction of coral reefs, but increased employment opportunities. And in the factors of “negative impact to living conditions”, “negative impact to marine environment”, “improved infrastructure”, and “positive economic impact” significantly influence residents support attitude towards tourism development. The residents of depend on the tourism, will affect their perception on the impact of marine tourism and tourism development support attitude. The results of this study not only provide reference to island countries in the development of marine tourism, but also offer specific directions and recommendations for future research. Original Research Article Chang and Huang; AJEE, 5(2): 1-14, 2017; Article no.AJEE. 38298 2
Comprehensive Analysis of Codon Usage Bias in Seven Epichloë Species and Their Peramine-Coding Genes

Codon usage bias plays an important role in shaping genomes and genes in unicellular species and multicellular species. Here, we first analyzed codon usage bias in seven Epichloë species and their peramine-coding genes. Our results showed that both natural selection and mutation pressure played a role in forming codon usage bias in seven Epichloë species. All seven Epichloë species contained a peramine-coding gene cluster. Interestingly, codon usage bias of peramine-coding genes were not affected by natural selection or mutation pressure. There were 13 codons more frequently found in Epichloë genome sequences, peramine-coding gene clusters and orthologous peramine-coding genes, all of which had a bias to end with a C nucleotide. In the seven genomes analyzed, codon usage was biased in highly expressed coding sequences (CDSs) with shorter length and higher GC content. Genes in the peramine-coding gene cluster had higher GC content at the third nucleotide position of the codon, and highly expressed genes had higher GC content at the second position. In orthologous peramine-coding CDSs, high expression level was not significantly correlated with CDS length and GC content. Analysis of selection pressure identified that the genes orthologous to peramine genes were under purifying selection. There were no differences in codon usage bias and selection pressure between peramine product genes and non-functional peramine product genes. Our results provide insights into understanding codon evolution in Epichloë species.
Molecular dynamics studies of a DNA‐binding protein: 2. An evaluation of implicit and explicit solvent models for the molecular dynamics simulation of the Escherichia coli trp repressor

Although aqueous simulations with periodic boundary conditions more accurately describe protein dynamics than in vacuo simulations, these are computationally intensive for most proteins. Trp repressor dynamic simulations with a small water shell surrounding the starting model yield protein trajectories that are markedly improved over gas phase, yet computationally efficient. Explicit water in molecular dynamics simulations maintains surface exposure of protein hydrophilic atoms and burial of hydrophobic atoms by opposing the otherwise asymmetric protein‐protein forces. This properly orients protein surface side chains, reduces protein fluctuations, and lowers the overall root mean square deviation from the crystal structure. For simulations with crystallographic waters only, a linear or sigmoidal distance‐dependent dielectric yields a much better trajectory than does a constant dielectric model. As more water is added to the starting model, the differences between using distance‐dependent and constant dielectric models becomes smaller, although the linear distance‐dependent dielectric yields an average structure closer to the crystal structure than does a constant dielectric model. Multiplicative constants greater than one, for the linear distance‐dependent dielectric simulations, produced trajectories that are progressively worse in describing trp repressor dynamics. Simulations of bovine pancreatic trypsin were used to ensure that the trp repressor results were not protein dependent and to explore the effect of the nonbonded cutoff on the distance‐dependent and constant dielectric simulation models. The nonbonded cutoff markedly affected the constant but not distance‐dependent dielectric bovine pancreatic trypsin inhibitor simulations. As with trp repressor, the distance‐dependent dielectric model with a shell of water surrounding the protein produced a trajectory in better agreement with the crystal structure than a constant dielectric model, and the physical properties of the trajectory average structure, both with and without a nonbonded cutoff, were comparable.
Intergroup Biases of the Intermediate-Status Group: The Effect of Stability and Instability of Social Stratification

ABSTRACT In two studies, the effect of instability of social stratification on intergroup behaviour of the intermediate-status group was investigated. In both studies, participants were categorised in the intermediate-status group. In Study 1, perceived instability was measured. Results show that the more social stratification was perceived as stable, the more intermediate-status group members were biased against the high-status group. Biases against both high- and low-status groups tended to become similar as social stratification was perceived as more unstable. In Study 2, instability was manipulated in upward and downward conditions. Results showed that, in the upwardly unstable condition, intermediate-status group members were more biased against high-status group, while in the downwardly unstable condition they were more biased against the low-status group.
South Turkwel: a new pliocene hominid site in Kenya.

New fossils discovered south of the Turkwel River in northern Kenya include an associated metacarpal, capitate, hamate, lunate, pedal phalanx, mandibular fragment, and teeth. These fossils probably date to around 3.5 m.y. a. Faunal information suggests that the environment at South Turkwel was predominantly bushland. The mandibular and dental remains are fragmentary, but the postcranial fossils are informative. Comparisons with Australopithecus, modern human, chimpanzee and gorilla hand bones suggest that the Turkwel hominid was most like Australopithecus afarensis and A. africanus. Carpometacarpal articulations are intermediate between those of modern humans and African apes, suggesting enhanced gripping capabilities compared with extant apes. The hamulus was strikingly large, similar in proportion only to Neandertals and some gorillas, suggesting the presence of powerful forearms and hands. There are no indicators of adaptations to knuckle-walking or suspensory locomotion in the hand, and the pedal phalanx suggests that this hominid was habitually bipedal.
PENGARUH PROFITABILITAS, KEPEMILIKAN MANAJERIAL, DER DAN FCF TERHADAP NILAI PERUSAHAAN MELALUI DPR

This research is meant to test: (1) the influence of profitability, managerial ownership, debt policy and free cash flow to the dividend policy and firm value; (2) the influence of dividend policy to the firm value; (3) the influence of profitability, managerial ownership, debt policy and free cash flow to the firm value which is mediated by dividend policy. The population of this research is all manufacturing companies which are listed in Indonesia Stock Exchange in 2008-2014. In this research, the sample collection has been determined by using purposive sampling, and 238 companies have been selected as samples. This research is done by using multiple linear regressions technique and the mediated variable is product of coefficient method. The result of this research shows that: (1) profitability, managerial ownership and free cash flow have influence to the dividend policy and firm value; (2) debt policy does not have any influence to the dividend policy; (3) debt policy and dividend policy does not have any influence to the firm value; (4) dividend policy does not mediate the correlation of profitability, managerial ownership, debt policy and free cash flow to the firm value. Keywords: Profitability, Managerial Ownership, Debt Policy, Free Cash Flow, Dividend Policy, Firm Value
PENGARUH KUALITAS AUDITOR, LIKUIDITAS, SOLVABILITAS DAN PROFITABILITAS TERHADAP OPINI AUDIT GOING CONCERN PADA SUB SEKTOR MAKANAN DAN MINUMAN YANG TERDAFTAR DI BURSA EFEK INDONESIA

This research is aimed to emprirically examines the influences of auditor quality, liquidity, solvability and profitability to the Going Concern Auditing Opinion (GCAO). This research’s populations are16 companies from sub sektor food and drink companies listed in Bursa Efek Indonesia (BEI) for the year 2011, 2012, and 2013. This research samples were 15 companies or 45 observation data which had close by purposive sampling. The data which used is secondary data that acquired from Bursa Efek Indonesia and it was analyzed by logistic regression. The result showed that the auditor quality, liquidity and profitability have no significant influence to the going concern opinion. Whereas the solvability have signifcant influence to the going concern opinion. Keywords: Going Concern Auditing Opinion, auditor quality, liquidity, solvability and profitability.
Efficacy and Long-Term Safety of a Dengue Vaccine in Regions of Endemic Disease.

BACKGROUND A candidate tetravalent dengue vaccine is being assessed in three clinical trials involving more than 35,000 children between the ages of 2 and 16 years in Asian-Pacific and Latin American countries. We report the results of long-term follow-up interim analyses and integrated efficacy analyses. METHODS We are assessing the incidence of hospitalization for virologically confirmed dengue as a surrogate safety end point during follow-up in years 3 to 6 of two phase 3 trials, CYD14 and CYD15, and a phase 2b trial, CYD23/57. We estimated vaccine efficacy using pooled data from the first 25 months of CYD14 and CYD15. RESULTS Follow-up data were available for 10,165 of 10,275 participants (99%) in CYD14 and 19,898 of 20,869 participants (95%) in CYD15. Data were available for 3203 of the 4002 participants (80%) in the CYD23 trial included in CYD57. During year 3 in the CYD14, CYD15, and CYD57 trials combined, hospitalization for virologically confirmed dengue occurred in 65 of 22,177 participants in the vaccine group and 39 of 11,089 participants in the control group. Pooled relative risks of hospitalization for dengue were 0.84 (95% confidence interval [CI], 0.56 to 1.24) among all participants, 1.58 (95% CI, 0.83 to 3.02) among those under the age of 9 years, and 0.50 (95% CI, 0.29 to 0.86) among those 9 years of age or older. During year 3, hospitalization for severe dengue, as defined by the independent data monitoring committee criteria, occurred in 18 of 22,177 participants in the vaccine group and 6 of 11,089 participants in the control group. Pooled rates of efficacy for symptomatic dengue during the first 25 months were 60.3% (95% CI, 55.7 to 64.5) for all participants, 65.6% (95% CI, 60.7 to 69.9) for those 9 years of age or older, and 44.6% (95% CI, 31.6 to 55.0) for those younger than 9 years of age. CONCLUSIONS Although the unexplained higher incidence of hospitalization for dengue in year 3 among children younger than 9 years of age needs to be carefully monitored during long-term follow-up, the risk among children 2 to 16 years of age was lower in the vaccine group than in the control group. (Funded by Sanofi Pasteur; ClinicalTrials.gov numbers, NCT00842530, NCT01983553, NCT01373281, and NCT01374516.).
On the stability of generalized gamma functional equation

We obtain the Hyers-Ulam stability and modified Hyers-Ulam stability for the equations of the form g(x+p)= ϕ(x)g(x) in the following settings: |g(x+p)−ϕ(x)g(x)| ≤ δ, |g(x+p)−ϕ(x)g(x) |≤ φ(x), |(g(x + p)/ϕ(x)g(x))−1 |≤ ψ(x). As a consequence we obtain the stability theorems for the gamma functional equation.