Miracle-dz/UniFAR-FTUs huggingface dataset:
University of Groningen Effects of a Multidisciplinary Intervention on the Presence of Neuropsychiatric Symptoms and Psychotropic Drug Use in Nursing Home Residents WithYoung-Onset Dementia Appelhof,

Citation for published version (APA): Appelhof, B. , Bakker, C. , de Vugt, M. E. , van Duinen-van den IJssel, J. C. L. , Zwijsen, S. A. , Smalbrugge, M. , Teerenstra, S. , Verhey, F. R. J., Zuidema, S. U. , & Koopmans, R. T. C. M. (2019). Effects of a Multidisciplinary Intervention on the Presence of Neuropsychiatric Symptoms and Psychotropic Drug Use in Nursing Home Residents WithYoung-Onset Dementia: Behavior and Evolution of Young-Onset Dementia Part 2 (BEYOND-II) Study. American Journal of Geriatric Psychiatry, 27(6), 581-589. https://doi.org/10.1016/j.jagp. 2018.12. 032
Rapid Visuomotor Responses Reflect Value-Based Decisions

Cognitive decision-making is known to be sensitive to the values of potential options, which are the probability and size of rewards associated with different choices. Here, we examine whether rapid motor responses to perturbations of visual feedback about movement, which mediate low-level and involuntary feedback control loops, reflect computations associated with high-level value-based decision-making. In three experiments involving human participants, we varied the value associated with different potential targets for reaching movements by controlling the distributions of rewards across the targets (Experiment 1), the probability with which each target could be specified (Experiment 2), or both (Experiment 3). We found that the size of rapid and involuntary feedback responses to movement perturbations was strongly influenced by the relative value between targets. A statistical model of relative value that includes a term for risk sensitivity provided the best fit to the visuomotor response data, illustrating that feedback control policies are biased to favor more frequent task success at the expense of the overall extrinsic reward accumulated through movement. Importantly however, the regulation of rapid feedback responses was associated with successful pursuit of high-value task outcomes. This implies that when we move, the brain specifies a set of feedback control gains that enable low-level motor areas not only to generate efficient and accurate movement, but also to rapidly and adaptively respond to evolving sensory information in a manner consistent with value-based decision-making. SIGNIFICANCE STATEMENT Current theories of sensorimotor control suggest that, rather than selecting and planning the details of movements in advance, the role of the brain is to set time-varying feedback gains that continuously transform sensory information into motor commands by feedback control. Here, we examine whether the fastest motor responses to perturbations of movement, which mediate low-level and involuntary feedback control loops (i.e., reflexes), reflect computations associated with high-level, value-based decision-making. We find that rapid feedback responses during reaching reflect the relative probabilities and rewards associated with target options. This suggests that low-order components of the sensorimotor control hierarchy, which generate rapid and automatic responses, can continuously evaluate evolving sensory evidence and initiate responses according to the prospect of reward.
The role of Vitamin E - Selenium - Folic acid supplementation in improving the sperm parameters after varicocelectomy: a randomized clinical trial.

PURPOSE In this study, we aimed to evaluate the effects of antioxidants including Vitamin E-Selenium-Folic acid (Vit E -Se- FA) on semen parameters following varicocelectomy (VCT). MATERIALS AND METHODS Sixty from 64 infertile male patients diagnosed with varicocele (VC) and underwent sub-inguinal VCT were included in the study. Following sub-inguinal VCT, the patients were randomized into two groups: 30 receiving Vit E-Se-FA supplementation for six months, and 30 as the control group with no treatment. The post-operative semen parameters of Vit E-Se-FA receiving group were compared with control group at the end of experiment. The sperm count, percentage of motile and abnormal sperms were considered. RESULTS There were statistically significant increasing in terms of count (P=.031) and motility (P=.01) of sperm after six months of receiving Vit E-Se-FA supplementation comparing with control group. CONCLUSION In conclusion, Vit E-Se-FA supplementation could improve the sperm parameters (count and motility of sperm) after VCT. Further studies with larger number of samples are needed to make a proper decision on Vit E-Se-FA supplementation after VCT.
Nonoperative Geriatric Hip Fracture Treatment Is Associated With Increased Mortality: A Matched Cohort Study.

OBJECTIVE To report the mortality data and life expectancy of geriatric hip fracture patients who underwent nonoperative management and compare that with a matched operative cohort. DESIGN Retrospective cohort study. SETTING Level 1 trauma center. PATIENTS Geriatric (65 years of age and older) femoral neck or intertrochanteric fracture (OTA/AO 31A and 31B) patients. INTERVENTION Operative treatment with either arthroplasty, cannulated screws, sliding hip screw device, or cephalomedullary nail compared with nonoperative cohort. MAIN OUTCOME MEASUREMENTS In-hospital, 30-day, and 1-year mortality. RESULTS Two hundred thirty-one patients, comprising 154 operative and 77 nonoperative patients, were compared. There were no significant differences among age, sex, fracture location, Charlson Comorbidity Index, preinjury living location, dementia, and history of cardiac arrhythmia between the 2 cohorts. Nonoperatively managed patients were found to have a significantly higher percent in-hospital (28.6 vs. 3.9; P < 0.0001), 30-day (63.6 vs. 11.0; <0.0001), and 1-year (84.4 vs. 36.4; P < 0.0001) mortality. The mean life expectancy after a hip fracture for the nonoperative cohort was significantly shorter than the operative group (221 vs. 1024 days; P < 0.0001). CONCLUSIONS Nonoperatively treated hip fracture patients had an 84.4% 1-year mortality that was significantly higher than a matched operative cohort. Our results demonstrate the bleak overall prognosis for nonoperatively treated geriatric hip fractures as well as the associated reduction in mortality with surgical treatment. Our findings offer helpful information by providing updated mortality data when discussing nonoperative hip fracture management with patients and their family. LEVEL OF EVIDENCE Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Parent-Adult Child Relations of Chinese Older Immigrants in the United States: Is There an Optimal Type?

OBJECTIVES This study aims to identify 1) different types of parent-child relations among Chinese older immigrants, 2) predictors of each relation type, and 3) the most "optimal" type that is associated with better psychological well-being of the older adults. METHODS Data were derived from 3,109 Chinese elderly in Chicago. Latent Class Analysis was used to identify structures of parent-child relations based on eight indicators of family solidarity. Logistic regressions were used to predict the relation types. Negative binomial and logistic regressions were used to examine the associations between the relation types and depression and quality of life (QoL). RESULTS Four types of parent-child relations emerged: unobligated ambivalent (44.77%), tight-knit (40.11%), detached (10.28%), and commanding conflicted (4.84%). Older adults' age, gender, marital status, health status, and immigration/acculturation experience were related to their relation types. While tight-knit relation was associated with the fewest depressive symptoms, older adults with unobligated ambivalent relations were the least likely to report good QoL. DISCUSSION The study illustrates the diverse and complex ways in which Chinese older immigrants and their children are connected. The findings suggest that a departure from the traditional norm of filial piety may presents a risk factor for this population's mental health.
Evaluation of physiological workload assessment methods using heart rate and accelerometry for a smart wearable system

Abstract Work metabolism (WM) can be accurately estimated by oxygen consumption (VO2), which is commonly assessed by heart rate (HR) in field studies. However, the VO2–HR relationship is influenced by individual capacity and activity characteristics. The purpose of this study was to evaluate three models for estimating WM compared with indirect calorimetry, during simulated work activities. The techniques were: the HR-Flex model; HR branched model, combining HR with hip-worn accelerometers (ACC); and HR + arm-leg ACC model, combining HR with wrist- and thigh-worn ACC. Twelve participants performed five simulated work activities and three submaximal tests. The HR + arm-leg ACC model had the overall best performance with limits of agreement (LoA) of −3.94 and 2.00 mL/min/kg, while the HR-Flex model had −5.01 and 5.36 mL/min/kg and the branched model, −6.71 and 1.52 mL/min/kg. In conclusion, the HR + arm-leg ACC model should, when feasible, be preferred in wearable systems for WM estimation. Practitioner Summary: Work with high energy demand can impair employees’ health and life quality. Three models were evaluated for estimating work metabolism during simulated tasks. The model combining heart rate, wrist- and thigh-worn accelerometers showed the best accuracy. This is, when feasible, suggested for wearable systems to assess work metabolism.
Positive Impact of Pulsed Electric Field on Lactic Acid Removal, Demineralization and Membrane Scaling during Acid Whey Electrodialysis

The drying of acid whey is hindered by its high mineral and organic acid contents, and their removal is performed industrially through expensive and environmentally impacting serial processes. Previous works demonstrated the ability to remove these elements by electrodialysis alone but with a major concern—membrane scaling. In this study, two conditions of pulsed electric field (PEF) were tested and compared to conventional DC current condition to evaluate the potential of PEF to mitigate membrane scaling and to affect lactic acid and salt removals. The application of a PEF 25 s/25 s pulse/pause combination at an initial under-limiting current density allowed for decreasing the amount of scaling, the final system electrical resistance by 32%, and the relative energy consumption up to 33%. The use of pulsed current also enabled better lactic acid removal than the DC condition by 10% and 16% for PEF 50 s/10 s and 25 s/25 s, respectively. These results would be due to two mechanisms: (1) the mitigation of concentration polarization phenomenon and (2) the rinsing of the membranes during the pause periods. To the best of our knowledge, this was the first time that PEF current conditions were used on acid whey to both demineralize and deacidify it.
Processing and Comprehension of Accented Speech by Monolingual and Bilingual Children

ABSTRACT This study tested the effect of Spanish-accented speech on sentence comprehension in children with different degrees of Spanish experience. The hypothesis was that earlier acquisition of Spanish would be associated with enhanced comprehension of Spanish-accented speech. Three groups of 5–6-year-old children were tested: monolingual English-speaking children, simultaneous Spanish-English bilingual children, and early English-Spanish bilingual children. The children completed a semantic judgment task in English on semantically meaningful and nonsensical sentences produced by a native English speaker and a native Spanish speaker characterized by a strong Spanish accent. All children were slower to respond to foreign accented speech, independent of language background. Monolingual and early bilingual children showed reduced comprehension accuracy of accented speech, but only for nonsensical sentences. Simultaneous bilingual children performed similarly to other groups for meaningful contexts, but were not as strongly affected by accent for nonsensical contexts. Together, the findings suggest that children’s language background has only a minor influence on processing of accented speech.
Reduced Incubation Time of the Modified Carbapenem Inactivation Test and Performance of Carbapenem Inactivation in a Set of Carbapenemase-Producing Enterobacteriaceae with a High Proportion of blaIMP Isolates

Accurate and timely identification of carbapenemase-producing Enterobacteriaceae (CPE) is critical for microbiology laboratories in order to facilitate infection prevention, reduce the spread of multiresistant Gram-negative bacilli, and reduce delays to effective antibiotic therapy. We undertook a study to compare the carbapenem inactivation method (CIM) against the modified carbapenem inactivation method (mCIM) on a broad range of CPE isolates from Australia, including a high proportion of blaIMP isolates. ABSTRACT Accurate and timely identification of carbapenemase-producing Enterobacteriaceae (CPE) is critical for microbiology laboratories in order to facilitate infection prevention, reduce the spread of multiresistant Gram-negative bacilli, and reduce delays to effective antibiotic therapy. We undertook a study to compare the carbapenem inactivation method (CIM) against the modified carbapenem inactivation method (mCIM) on a broad range of CPE isolates from Australia, including a high proportion of blaIMP isolates. Furthermore, we evaluated the performance of the mCIM with a reduced incubation time using automated incubation and digital plate reading in order to better facilitate quick confirmation of carbapenemases. The overall sensitivity of the mCIM was 98.2%, compared to 95.6% for the CIM. The minimum incubation time for the mCIM while maintaining its sensitivity was 12 hours. Both the CIM and mCIM perform well on a broad range of CPE isolates seen in Australia.
The genetic architecture of teosinte catalyzed and constrained maize domestication

Significance Crop domestication is a well-established system for understanding evolution. We interrogated the genetic architecture of maize domestication from a quantitative genetics perspective. We analyzed domestication-related traits in a maize landrace and a population of its ancestor, teosinte. We observed strong divergence in the underlying genetic architecture including change in the genetic correlations among traits. Despite striking divergence, selection intensities were low for all traits, indicating that selection under domestication can be weaker than natural selection. Analyses suggest total grain weight per plant was not improved and that genetic correlations placed considerable constraint on selection. We hope our results will motivate crop evolutionists to perform similar work in other crops. The process of evolution under domestication has been studied using phylogenetics, population genetics–genomics, quantitative trait locus (QTL) mapping, gene expression assays, and archaeology. Here, we apply an evolutionary quantitative genetic approach to understand the constraints imposed by the genetic architecture of trait variation in teosinte, the wild ancestor of maize, and the consequences of domestication on genetic architecture. Using modern teosinte and maize landrace populations as proxies for the ancestor and domesticate, respectively, we estimated heritabilities, additive and dominance genetic variances, genetic-by-environment variances, genetic correlations, and genetic covariances for 18 domestication-related traits using realized genomic relationships estimated from genome-wide markers. We found a reduction in heritabilities across most traits, and the reduction is stronger in reproductive traits (size and numbers of grains and ears) than vegetative traits. We observed larger depletion in additive genetic variance than dominance genetic variance. Selection intensities during domestication were weak for all traits, with reproductive traits showing the highest values. For 17 of 18 traits, neutral divergence is rejected, suggesting they were targets of selection during domestication. Yield (total grain weight) per plant is the sole trait that selection does not appear to have improved in maize relative to teosinte. From a multivariate evolution perspective, we identified a strong, nonneutral divergence between teosinte and maize landrace genetic variance–covariance matrices (G-matrices). While the structure of G-matrix in teosinte posed considerable genetic constraint on early domestication, the maize landrace G-matrix indicates that the degree of constraint is more unfavorable for further evolution along the same trajectory.
Impending rupture of aortic aneurysm eroding skin and sternum: a rare condition

A rare presentation of ascending aortic aneurysm eroding into the anterior chest wall and skin is described. Only a few reports of this lethal condition associated with luetic disease have been published previously. A 72-year-old man with a history of blunt chest injury subsequently developed a saccular aneurysm of the ascending aorta protruding out of the anterior chest wall. He was successfully treated with a surgical intervention.
Improved Firefly Algorithm: A Novel Method for Optimal Operation of Thermal Generating Units

This paper presents a novel improved firefly algorithm (IFA) to deal the problem of the optimal operation of thermal generating units (OOTGU) with the purpose of reducing the total electricity generation fuel cost. The proposed IFA is developed based on combining three improvements. The first is to be based on the radius between two solutions, the second is updated step size for each considered solution based on different new equations, and the third is to slightly modify a formula producing new solutions by using normally distributed random numbers and canceling uniform random numbers of conventional firefly algorithm (FA). The effect of each proposed improvement on IFA is investigated by executing five benchmark functions and two different systems. The performance of IFA is investigated on six other study cases consisting of different types of objective function and complex level of constraints. The objective function considers single fuel with quadratic form and nonconvex form, and multifuels with the sum of several quadratic and nonconvex functions while a set of constraints taken into account are power loss, prohibited zone, ramp rate limit, spinning reserve, and all constraints in transmission power networks. The obtained results indicate the proposed improvements in terms of high optimal solution quality, stabilization of search ability, and fast convergence compared with FA. In addition, the comparisons with other methods also lead to a conclusion that the proposed method is a very promising optimization tool for systems with quadratic fuel cost function and with complicated constraints.
Cholangiocarcinoma: Epidemiology and risk factors

Cholangiocarcinoma (CCA) is a heterogeneous disease arising from a complex interaction between host‐specific genetic background and multiple risk factors. Globally, CCA incidence rates exhibit geographical variation, with much higher incidence in parts of the Eastern world compared to the West. These differences are likely to reflect differences in geographical risk factors as well as genetic determinants. Of note, over the past few decades, the incidence rates of CCA appear to change and subtypes of CCA appear to show distinct epidemiological trends. These trends need to be interpreted with caution given the issues of diagnosis, recording and coding of subtypes of CCA. Epidemiological evidences suggest that in general population some risk factors are less frequent but associated with a higher CCA risk, while others are more common but associated with a lower risk. Moreover, while some risk factors are shared by intrahepatic and both extrahepatic forms, others seem more specific for one of the two forms. Currently some pathological conditions have been clearly associated with CCA development, and other conditions are emerging; however, while their impact in increasing CCA risk as single etiological factors has been provided in many studies, less is known when two or more risk factors co‐occur in the same patient. Moreover, despite the advancements in the knowledge of CCA aetiology, in Western countries about 50% of cases are still diagnosed without any identifiable risk factor. It is therefore conceivable that other still undefined etiologic factors are responsible for the recent increase of CCA (especially iCCA) incidence worldwide.
Multiple supporting cell subtypes are capable of spontaneous hair cell regeneration in the neonatal mouse cochlea

ABSTRACT Supporting cells (SCs) are known to spontaneously regenerate hair cells (HCs) in the neonatal mouse cochlea, yet little is known about the relative contribution of distinct SC subtypes which differ in morphology and function. We have previously shown that HC regeneration is linked to Notch signaling, and some SC subtypes, but not others, lose expression of the Notch effector Hes5. Other work has demonstrated that Lgr5-positive SCs have an increased capacity to regenerate HCs; however, several SC subtypes express Lgr5. To further investigate the source for spontaneous HC regeneration, we used three CreER lines to fate-map distinct groups of SCs during regeneration. Fate-mapping either alone or combined with a mitotic tracer showed that pillar and Deiters' cells contributed more regenerated HCs overall. However, when normalized to the total fate-mapped population, pillar, Deiters', inner phalangeal and border cells had equal capacity to regenerate HCs, and all SC subtypes could divide after HC damage. Investigating the mechanisms that allow individual SC subtypes to regenerate HCs and the postnatal changes that occur in each group during maturation could lead to therapies for hearing loss. Summary: Several supporting cell subtypes, in particular pillar cells and Deiters’ cells, act as the source of spontaneously regenerated hair cells in the neonatal mouse cochlea.
Food insecurity and violence in a prospective cohort of women at risk for or living with HIV in the U.S.

Background Food insecurity and violence are two major public health issues facing U.S. women. The link between food insecurity and violence has received little attention, particularly regarding the temporal ordering of events. The present study used data from the Women’s Interagency Human Immunodeficiency Virus Study to investigate the longitudinal association of food insecurity and violence in a cohort of women at risk for or living with HIV. Methods Study participants completed six assessments from 2013–16 on food insecurity (operationalized as marginal, low, and very low food security) and violence (sexual or physical, and psychological). We used multi-level logistic regression, controlling for visits (level 1) nested within individuals (level 2), to estimate the association of experiencing violence. Results Among 2,343 women (8,528 visits), we found that victims of sexual or physical violence (odds ratio = 3.10; 95% confidence interval: 1.88, 5.19) and psychological violence (odds ratio = 3.00; 95% confidence interval: 1.67, 5.50) were more likely to report very low food security. The odds of experiencing violence were higher for women with very low food security at both the current and previous visit as compared to only the current visit. HIV status did not modify these associations. Conclusions Food insecurity was strongly associated with violence, and women exposed to persistent food insecurity were even more likely to experience violence. Food programs and policy must consider persistent exposure to food insecurity, and interpersonal harms faced by food insecure women, such as violence.