Miracle-dz/UniFAR-FTUs huggingface dataset:
Quality of life in adults and children with asthma and rhinitis

Many clinicians now recognize the importance of incorporating an assessment of health‐related quality of life (HRQL) into their clinical studies and practice. Conventional clinical measures provide valuable information about the status of the affected organ system, but they rarely capture the functional impairments (physical, emotional, and social) that are important to the patients in their everyday lives. In order to obtain a complete picture of a patient's health status, both the conventional clinical indices and the patient's HRQL must be measured. Both adults and children with asthma and rhinitis are distressed by the symptoms, and they are limited in their day‐to‐day activities such as sports, work or school work, and participation in other activities with friends. In addition, both adults and children experience emotional strain as a result of both conditions. Disease‐specific HRQL questionnaires have been developed and validated for both adults and children with asthma and rhinitis. These questionnaires have good measurement properties and validity and can be used in both clinical trials and clinical practice to assess the impact of the condition on a patient's life. Since one of the aims of treatment is to ensure that patients benefit from it, an essential component of clinical assessment should be an evaluation of HRQL.
High anabolic potential of essential amino acid mixtures in advanced nonsmall cell lung cancer.

BACKGROUND Conventional nutritional supplements are not or only partly successful in inducing protein accretion in advanced cancer, suggesting an attenuated anabolic response. To prevent muscle wasting and its deleterious consequences, generating an anabolic response is crucial. Dietary essential amino acids (EAA) have anabolic properties in other wasting diseases; however, data in advanced cancer are lacking. PATIENTS AND METHODS In 13 patients with advanced nonsmall-cell lung cancer (NSCLC) (stage III and IV) and 11 healthy age-matched subjects, we measured protein synthesis and breakdown of the whole body, and net protein anabolism (difference between protein synthesis and breakdown) after intake of 14 g of free EAA with high leucine levels (EAA/leucine) versus a balanced amino acid mixture containing both EAA and non-EAA as present in whey protein, according to a randomized, double-blind, crossover design. RESULTS Protein synthesis and net protein anabolism were higher after intake of the EAA/leucine than the balanced amino acid mixture (P < 0.001), independent of presence of cancer. A highly significant linear relationship between net protein anabolism and the amount of EAA available in the systemic circulation (R(2): 0.85, P < 0.001) was found in both groups. The presence of muscle or recent weight loss, systemic inflammatory response, or length of survival did not influence this relationship. High leucine levels in the EAA/leucine mixture was of no anabolic benefit. CONCLUSIONS There is no anabolic resistance or attenuated anabolic potential to intake of 14 g of EAA/leucine or balanced amino acid mixture in advanced (mainly stage III) NSCLC. The high anabolic potential of dietary EAA in cancer patients is independent of their nutritional status, systemic inflammatory response or disease trajectory, suggesting a key role of EAA in new nutritional approaches to prevent muscle loss, thereby improving outcome of patients with advanced cancer. CLINICALTRAILSGOV NCT01172314.
Leveraging human assets for MNCs performance: the role of management development, human resource system and employee engagement

Abstract This study aims to test the effect of each dimension of Management Development Index, human resource system (HRS) and employee engagement (EE) on firm performance. Additionally, the study attempts to establish if EE is a missing link in the HRS–firm performance relationship. Using disproportionate stratified random sampling, data were collected from a sample of managerial staff of 10 multinational corporations to test the hypotheses. A two-stage structural equation modeling technique was used to test the hypothesized relationships among the constructs. The findings indicate that management development and HRS are associated with firm performance. The study results further support EE as a mediator in the HRS–firm performance relationship, albeit partially.
The use of memoranda of understanding in fostering inter-agency collaboration: A qualitative study of health services agencies serving vulnerable populations in Baltimore, USA

Introduction: We examined whether mandated collaboration reflected in memoranda of understanding (MOUs) developed by health agencies to meet funder expectations is effective in fostering inter-agency collaboration. Methods: We conducted 22 semi-structured interviews from late 2010 to early 2012 in Baltimore, USA, with representatives of 17 HIV service agencies, three local health department units, and one agency that closed in 2008 (two interviews). Results: While there was no consensus, most respondents perceived MOUs negatively, mainly because the process of obtaining signed MOUs was time consuming; frontline staff was mostly unaware of MOUs, agencies did not necessarily work with agencies they signed MOUs with and MOUs were rarely evaluated after being signed. A few agencies reported that MOUs could keep agencies focused and set mutual expectations. The local health department acknowledged shortcomings in MOUs but emphasized that MOUs could help agencies plan for referring clients when their own capacity was full. Conclusions: Although many agencies acknowledged the importance of collaboration, most respondents found that MOUs lacked practical utility. Grant-makers should consult sub-grantees to develop alternative means of fostering collaboration that would be perceived as relevant by both parties.
IPO underpricing phenomenon on the karachi stock exchange

In this study the risk-adjusted performance of IPO firms listed on the KSE from 2000 to 2012 is analyzed. The objective is to provide insights of the underpricing (first trading day) of IPOs and to find out the determinants of underpricing in the light of asymmetric information and signaling theories. The results indicate that underpricing prevails on the KSE. The level of underpricing with regard to the marked adjusted model is found to be 28.28 percent for the full sample of 83 IPOs, which shows that investors can make a market adjusted profit of 28.28 percent by investing in new issues of IPO firms. The profit opportunity for the day traders is also observed. The year-wise analysis of the level of underpricing shows that the overall amount of level of underpricing decreased over the succeeding years. Furthermore, the level of underpricing is observed in all sectors except equity investment instruments, technology hardware and equipment and personal goods. The risk adjusted performance of IPO firms is also measured with the help of five models by using matched firm techniques. The level of underpricing is observed to be 39.64 percent for the market adjusted model, 42.63 percent for market model, 42.31 percent for CAPM, 42.84 percent for the Fama-French three-factor model and 42.99 percent for the four-factor model. The results indicate that the choice of model does not matter while measuring the risk adjusted returns of IPO firms on the first trading day.
Characteristics of Resting and Breeding Habitats of Adult Sand Flies in the Judean Desert

ABSTRACT: Recently, in several areas of the Middle East, a sharp increase of cutaneous leishmaniasis was observed in suburbs of larger towns including Jerusalem. In some of these areas, poor housing conditions and unsuitable waste management was suspected to provide ideal conditions for sand fly breeding, but hard data on diurnal resting sites and breeding habitats of most sand fly species are scant. In this study, we chose 16 sites on both slopes and the bottom of a natural valley in the Judean Desert to conduct a survey of sand fly distribution with emergence traps. Altogether, 1,261 sand flies, 52% Phlebotomus syriacus, 22% P. sergenti, 14% P. papatasi and 12% P. tobbi were caught. About two thirds of the flies caught were resting, while the other third emerged from breeding sites. All four species showed clear preferences for resting and breeding sites, but generally, most sand flies were breeding in the more humid habitats, namely the bottom of the valley, the adjacent north facing slope, terraces on the north facing slope, and caves. The vegetation cover also appeared to be important for resting habitats; on the bottom of the valley more than six times as many sand flies were collected in areas covered by dense vegetation than in areas with low vegetation cover. P. sergenti seemed also to better tolerate the drier habitats, which might explain the abundance of this species in the arid Judean Desert.
Consumer Responses to High Service Attentiveness: A Cross-Cultural Examination

Although the literature generally indicates that service attentiveness can increase consumer satisfaction, providing extra care and attention in service encounters may backfire and lead to negative consumer outcomes. In addition, because of cross-cultural differences, the effects of high service attentiveness may vary across international markets. The authors conduct a qualitative study, a field experiment, and two laboratory experiments in three countries (Canada, the United States, and China) across various service contexts (hairdressing, telecommunications, and computer repair) to examine cross-cultural consumer responses toward high service attentiveness. Consumers’ negative responses toward high service attentiveness are mediated by their suspicion of ulterior motive, which varies according to their self-construal. Specifically, consumers with an interdependent self-construal (either chronic or primed) tend to have greater suspicion of and negative responses toward high service attentiveness. Furthermore, the effect of interdependent self-construal fostering greater suspicion is attributed to a sharper in-group (vs. out-group) distinction, which is mitigated when the service employee is perceived to be an in-group member. The authors conclude by discussing the theoretical and managerial implications and suggesting future research directions.
Distribution feeder one-line diagrams automatic generation from geographic diagrams based on GIS

Geographic information systems (GIS) are computer-based systems designed to support the capture, management, manipulation, analysis, and modeling of spatially referenced data. At present, GIS has been extensively used in the energy management system and provides visualized platform to electrical distribution system analysis, design and operation, that is, AM/FM/GIS. One-line diagrams are widely used to represent the electrical distribution system current state and its facilities connectivity relationship. Once AM/FM/GIS integrate with SCADA, the real time operational data obtained, one-line diagrams could represent electrical distribution system dynamic topological relationship. In the past, one-line diagrams was produced by means of manual working using CAD or more original analogy circuit board, it is inefficient and easily error. Therefore it's significant to implement automatic generation one- line diagram, it can reduce the human errors and the huge effort in a manual generation technique. This paper presents a methodology to automatically build these diagrams based on the usage of geospatial data from AM/FM/GIS. All electrical distribution system facilities including the network buses, branches, switches and transformers were abstracted into edges and nodes. With the aid of the routing methodology in the large scale integration, an intelligent routing algorithm for the power system graph is presented. The intelligent routing algorithm permits the elimination of intersection and overlap of buses and other facilities. The approach was successfully demonstrated with some city district electrical distribution system.
A comprehensive evaluation of the toxicology of cigarette ingredients: essential oils and resins

Context: A total of 32 essential oils and resins were added individually to experimental cigarettes. Objective: A battery of tests was used to compare the toxicity of mainstream smoke from these experimental cigarettes. The lowest target inclusion level was 100 ppm and the highest was 100,000 ppm. Materials and methods: Smoke from each of the experimental cigarette was evaluated using analytical chemistry and in vitro bacterial (Salmonella, five strains) mutagenicity and cytotoxicity (neutral red uptake) assays. For seven of the ingredients (carob bean, carob bean extract, carrageenan, chamomile flower Hungarian oil, guar gum, peppermint oil, and spearmint oil), 90-day smoke inhalation studies with rats were also performed. Results: In general, inclusion levels resulted in minimal changes in smoke chemistry; the exceptions were PO and SO, where reductions to 40–60% of control values were noted, possibly indicating a tobacco displacement effect. Cytotoxicity and mutagenicity were unaffected by any of the test ingredients, except for a dose-related reduction in cytotoxicity for SO. There were very few statistically significant differences within any of the seven inhalation studies; when present, the differences were sporadic and inconsistent between sexes. The addition of SO appeared to depress body weight gain and increase the atrophy of olfactory epithelia, but only in males. Conclusion: The essential oils and resins tested here as ingredients in experimental cigarettes show minimal toxicological sequelae, even at high inclusion levels. The highest inclusion level for SO showed some equivocal responses.
Visual information can hinder working memory processing of speech.

PURPOSE The purpose of the present study was to evaluate the new Cognitive Spare Capacity Test (CSCT), which measures aspects of working memory capacity for heard speech in the audiovisual and auditory-only modalities of presentation. METHOD In Experiment 1, 20 young adults with normal hearing performed the CSCT and an independent battery of cognitive tests. In the CSCT, they listened to and recalled 2-digit numbers according to instructions inducing executive processing at 2 different memory loads. In Experiment 2, 10 participants performed a less executively demanding free recall task using the same stimuli. RESULTS CSCT performance demonstrated an effect of memory load and was associated with independent measures of executive function and inference making but not with general working memory capacity. Audiovisual presentation was associated with lower CSCT scores but higher free recall performance scores. CONCLUSIONS CSCT is an executively challenging test of the ability to process heard speech. It captures cognitive aspects of listening related to sentence comprehension that are quantitatively and qualitatively different from working memory capacity. Visual information provided in the audiovisual modality of presentation can hinder executive processing in working memory of nondegraded speech material.
Diethyldithiocarbamate Causes Nigral Cell Loss and Dopamine Depletion with Nontoxic Doses of MPTP

Although nontoxic when administered alone, diethyldithiocarbamate (DDC) is known to enhance the dopamine-depleting effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse striatum. The purpose of the present study was twofold: (i) to carefully characterize the effects of DDC on MPTP-induced degeneration of dopaminergic neurons in substantia nigra pars compacta using unbiased, stereological cell counting techniques and (ii) to determine whether or not DDC can convert a nontoxic dose of MPTP into one which is clearly toxic on dopaminergic neurons in the substantia nigra. A single low dose of MPTP (15 mg/kg intraperitoneally (ip)) was used for these studies, which failed to induce any neurochemical or histological effects on the nigrostriatal system of C57BL/6 mice when administered alone. However, when animals were pretreated with DDC (400 mg/kg ip), the same dose of MPTP resulted in a 50% loss of neurons in the substantia nigra pars compacta, as well as a 70% reduction in striatal dopamine (DA). A 31% reduction of DA in the ventral mesencephalon was also seen. This combined regimen of DDC and MPTP was not significantly different from a maximally tolerated "toxic" dose of MPTP alone (15 mg/kg x 4, 1 h apart, ip). As expected, animals receiving DDC alone did not show any dopamine depletion nor nigral neuronal loss. The present study confirms previous work suggesting that DDC enhances MPTP-induced nigral cell loss and shows for the first time that DDC can "unmask" MPTP toxicity. These observations could have implications for theories on the cause of Parkinson's disease.
Critical Determinants of Human α-Defensin 5 Activity against Non-enveloped Viruses*

Background: The molecular basis for human α-defensin 5 (HD5) binding to non-enveloped viruses is unknown. Results: Residues critical for virus binding and antiviral activity were identified by mutational analysis. Conclusion: Multimerization, hydrophobicity, and specific arginine residues dictate HD5 antiviral activity. Significance: These studies inform the role of enteric α-defensins in immunity against non-enveloped viruses. Human α-defensins, such as human α-defensin 5 (HD5), block infection of non-enveloped viruses, including human adenoviruses (AdV), papillomaviruses (HPV), and polyomaviruses. Through mutational analysis of HD5, we have identified arginine residues that contribute to antiviral activity against AdV and HPV. Of two arginine residues paired on one face of HD5, Arg-28 is critical for both viruses, while Arg-9 is only important for AdV. Two arginine residues on the opposite face of the molecule (Arg-13 and Arg-32) and unpaired Arg-25 are less important for both. In addition, hydrophobicity at residue 29 is a major determinant of anti-adenoviral activity, and a chemical modification that prevents HD5 self-association was strongly attenuating. Although HD5 binds to the capsid of AdV, the molecular basis for this interaction is undefined. Capsid binding by HD5 is not purely charge-dependent, as substitution of lysine for Arg-9 and Arg-28 was deleterious. Analysis of HD5 analogs that retained varying levels of potency demonstrated that anti-adenoviral activity is directly correlated with HD5 binding to the virus, confirming that the viral capsid rather than the cell is the relevant target. Also, AdV aggregation induced by HD5 binding is not sufficient for neutralization. Rather, these studies confirm that the major mechanism of HD5-mediated neutralization of AdV depends upon specific binding to the viral capsid through interactions mediated in part by critical arginine residues, hydrophobicity at residue 29, and multimerization of HD5, which increases initial binding of virus to the cell but prevents subsequent viral uncoating and genome delivery to the nucleus.
Transcriptomic features of primary prostate cancer and their prognostic relevance to castration-resistant prostate cancer

Although various mechanisms of castration-resistant prostate cancer (CRPC) have been discovered, reliable biomarkers for monitoring CRPC progression are lacking. We sought to identify molecules that predict the progression of advanced prostate cancer (AdvPC) into CRPC. The study used primary-site samples (N=45 for next-generation sequencing (NGS); N=243 for real-time polymerase chain reaction) from patients with prostate cancer (PC). Five public databases containing microarray data of AdvPC and CRPC samples were analyzed. The NGS data showed that each progression step in PC associated with distinct gene expression profiles. Androgen receptor (AR) associated with tumorigenesis, advanced progression, and progression into CRPC. Analysis of the paired and unpaired AdvPC and CRPC samples in the NGS cohort showed that 15 genes associated with progression into CRPC. This was validated by cohort-1 and public database analyses. Analysis of the third cohort with AdvPC showed that higher serine peptidase inhibitor, Kazal type 1 (SPINK1) and lower Sp8 transcription factor (SP8) expression associated with progression into CRPC (log-rank test, both P<0.05). Multivariate regression analysis showed that higher SPINK1 (Hazard Ratio (HR)=4.506, 95% confidence intervals (CI)=1.175–17.29, P=0.028) and lower SP8 (HR=0.199, 95% CI=0.063–0.632, P=0.006) expression independently predicted progression into CRPC. Gene network analysis showed that CRPC progression may be mediated through the AR-SPINK1 pathway by a HNF1A-based gene network. Taken together, our results suggest thatSPINK1 and SP8 may be useful for classifying patients with AdvPC who have a higher risk of progressing to CRPC.
Failure of protein to improve time trial performance when added to a sports drink.

INTRODUCTION Recent studies have reported that adding approximately 2% protein to a carbohydrate sports drink increased cycle endurance capacity compared with carbohydrate alone. However, the practical implications of these studies work are hampered by the following limitations: (a) the rate of carbohydrate ingestion was less than what is considered optimal for endurance performance, and (b) the performance test (exercise time to fatigue) did not mimic the way in which athletes typically compete (i.e., a race in which a fixed distance or set amount of work is performed as quickly as possible). PURPOSE We tested the hypothesis that adding 2% protein to a 6% carbohydrate drink (CHO-PRO) would improve 80-km cycling time trial performance, as compared with a 6% carbohydrate drink (CHO) and a nonenergetic sweetened placebo (PLAC). METHODS Ten trained male cyclists (24 +/- 2 yr; VO2peak = 63 +/- 2 mL.kg(-1). min(-1); mean +/- SE) performed an 80-km laboratory time trial (TT) on three occasions separated by 7 d. In a double-blind crossover manner, subjects ingested CHO-PRO, CHO, or PLAC at a rate of 250 mL every 15 min with no temporal, verbal, or physiological feedback. RESULTS Time to complete the TT was 4.4% lower (P < 0.002) during CHO (135 +/- 9 min) and CHO-PRO (135 +/- 9) compared with PLAC (141 +/- 10), with no difference between CHO and CHO-PRO (P = 0.92). CONCLUSION Ingesting 6% carbohydrate at a rate of 1 L.h(-1) (60 g.h(-1)) improved an 80-km TT performance in trained male cyclists. However, adding 2% protein to a 6% carbohydrate drink provided no additional performance benefit during a task that closely simulated the manner in which athletes typically compete.
Effects of market position and competition on rural hospital closures.

OBJECTIVE To examine the dynamic effects of competition and hospital market position on rural hospital closures. DATA SOURCE/STUDY SETTING Analysis of all rural community hospitals operating between 1984 and 1991, with the exception of sole-provider hospitals. Data for the study are obtained from four sources: the AHA Annual Surveys of Hospitals, the HCFA Cost Reports, the Area Resource File, and a hospital address file constructed by Geographic Inc. DATA COLLECTION AND ANALYSIS Variables are merged to construct pooled, time-series observations for study hospitals. Hospital closure is specified as a function of hospital market position, market level competition, and control variables. Discrete-time logistic regressions are used to test hypotheses. PRINCIPAL FINDINGS Rural hospitals operating in markets with higher density had higher risk of closure. Rural hospitals that differentiated from others in the market on the basis of geographic distance, basic services, and high-tech services had lower risks of closure. Effects of market density on closure disappeared when market position was included in the model, indicating that differentiation in markets should be taken into account when evaluating the effects of competition on rural hospital closure. CONCLUSIONS Our findings suggest that rural hospitals can reduce competitive pressures through differentiation and that accurate measures of competition in geographically defined market areas are critical for understanding competitive dynamics among rural hospitals.