Miracle-dz/UniFAR-FTUs huggingface dataset:
Feasibility Controlling Hemoglobin A1c by Oral Hygiene Improvement: A Pilot Study

Purpose: Patients with diabetes mellitus are prone to be bacteremia. The major side effect of diabetes mellitus is caused by bacteremia. However, conventional periodontal treatment does not focus mainly on the elimination of pathogenic bacteria. Therefore, the aim of this study was to the management of oral bacteria improve some symptoms of diabetes mellitus. Material and Method: We monitored Hemoglobin A1c (HbA1c) of five subjects after removed oral bacteria on the tooth surface by antibiotics using custom made tray. By using the results, simulation model was constructed. Result: By the simulation, HbA1c levels declined over time and decreased to 6.0%. However, it took at least 600 days to come up to 6.0%. The higher the level of HbA1c at baseline, the more time takes to improve HbA1c level. Subjects with 7.3% HbA1c at baseline required 2,400 days to achieve 6.0% HbA1c. Conclusion: The results of this study suggest that HbA1c may be improved by oral bacterial control. Clinical studies suggest that a long observational period is required to obtain high quality evidence. Keywords: Oral hygiene; Hemoglobin A1c; Mixed effect model
Women's Skin Care Factors Affecting Korean Women's Skin and Beauty Industry Market

Purpose – This study aims to explore women's beauty industry market and growth development by identifying the main factors of women's perception of skin health care. Research design, data, and methodology – The survey was conducted on women aged 20 to 60 living in Seoul. For the statistical analysis, frequency analysis, t-test and one-way ANOVA were conducted, and significant differences in p<0.05 were tested through the multiple range test of the Scheffe. The factor analysis was conducted to verify the validity of questions, and the reliability was determined by the coefficient of Cronbach's α . Results – The lower the age, the higher the perception of the skin, and women pay a higher price for skin health as a provisional customer. 'Acne care' was the most common skin condition (32.8%), 'life style' (79.8%) was the most important part of skin care. Final education was the highest level of skin care for women with a professional background (M=3.41) (F=4.028, p<.05). Conclusions – The differences in the recognition of health knowledge by age, marital status, and household monthly income were significant, but there was no difference between jobs and final education. Customers who use less skin care than customers who frequently use the skin care center were more aware of skin health, and women who have a high awareness of skin are more interested in aging and regenerating due to the skin care.
Immunostimulatory and Anti-inflammatory Effect of Ganoderma Lucidum on Breast Cancer Patients

Background Breast cancer (BC) is the most common cancer among women. A key factor in tumour development is the evasion of immune detection therefore; search for alternative medicines with the ability to improve function of immune system and targets tumours cells has received growing interest. Ganoderma lucidum (GL) has been demonstrated to possess anti-tumour and immunomodulatory activities. Little is known about immunomodulatory effect of GL on BC patients when used with chemotherapeutic agents. We aim to investigate the level of immune biomarkers; interferon-γ (IFN-γ), tumour necrotic factor-α (TNF-α), inteleukin-8 (IL-8) and adiponectin in these patients. Material and Methods Forty female patients with BC were included and divided equally into two groups: Group 1 received chemotherapy alone and Group 2 received chemotherapy plus GL capsules (1000 mg twice daily). Blood samples were obtained from all patients before and after 4 cycles of chemotherapy. These samples were analysed to identify the levels of IFN-γ, TNF-α, IL-8 and adiponectin. Results After the treatment period, there was significant increase in the level of IFN-γ (P=0.0024) and a significant decrease in the mean serum levels of TNF-α (P=0.0004) and IL-8 (P=0.019) in patients treated with concurrent GL and chemotherapy. A non-significant difference was found between pre and post treatment in the mean serum levels of TNF-α, IFN-γ and IL-8 in patients received chemotherapy only. The mean serum levels of adiponectin in both groups did not show any significant difference when compared to pre-treatment levels. Conclusion The present study showed that the use of GL in-combination with chemotherapy could have immune stimulatory, anti-inflammatory and anti-metastatic activity that can enhance therapeutic responsiveness of BC patients to chemotherapy and improve their quality of life during treatment. More research is needed to confirm these results. In addition, clinical evaluation of benefit and outcome are on going
Epidemiology And Clinical Pattern Of Atopic Dermatitis In 100 Children seen In A City Hospital

A topic desmatitis is a fairly common disorder in the paediatric population. One hundred children were evaluated for epidemiology and clinical pattern with reference to age, age of onset, history of atopy, seasonal variation, type, distribution and extent of eczema etc. The results were tabulated, analysed and compared with data from previous studies. Findings such as onset at a very young age, a male preponderance, summer aggravation, facial dermatitis in preschool children, more acute presentation less disease severity and other regional variations are discussed.
Innervation of the thoracolumbar fascia

The aim of the study was to obtain information on the sensory functions of the thoracolumbar fascia (TLF). The types of nerve fibres present in the TLF were visualized with specific antibodies to neuropeptides and sympathetic fibres. Most data were obtained from the TLF in rats, but some findings from the human fascia are also included. The only receptive nerve ending found was the free nerve ending, i.e. no corpuscular receptors existed in our specimen. An exclusive innervation with free nerve endings speaks for a nociceptive function, but the TLF may also fulfill proprioceptive functions, since many of the free nerve endings have a low mechanical threshold. Most of the fibres could be visualized with antibodies to CGRP [calcitonin gene- related peptide (CGRP)] and SP [substance P (SP)]. The latter ones most likely were nociceptors. The TLF contained a great proportion of postganglionic sympathetic fibres, which may be vasoconstrictors. A comparison between an inflamed and intact fascia showed an increase of the CGRP- and SP-positive fibres in the inflamed TLF. This finding could be one explanation for the low back pain of many patients, since practically all lesions of the fascia are accompanied by a sterile inflammation.
Vitamin D and Breast Cancer - Chemoprevention or Therapy?

Most evidence studies have concluded that there is an inverse association between blood levels of calcidiol and cancer incidence and survival. These findings especially apply in colorectal and breast cancer (BC). The phenomenon of the multidirectional activity of vitamin D is possibly due to the presence of the vitamin D receptor (VDR) in most non-skeletal human cells including cancer cells. The crucial is that a wide range of the genes regulated by VDR are related with cell proliferation, differentiation, angiogenesis and metastasis. The aim of this paper was to present recent data on the possible role of vitamin D as an chemopreventive or therapeutic agent against BC through considering the anticancer mechanisms induced by this vitamin as well as presenting the results of clinical studies on the impact of vitamin D status on BC incidence, survival and response to therapy. This review is based on an electronic search of articles in the PubMed database, including papers published mostly within last five years in that field and selected according to the following criteria: well commented studies concerning the association between vitamin D status and BC risk, response to therapy or survival, with the vitamin D supplementation outline and statistical data.
Changes in immunity characteristics in patients with small (T1) choroidal melanoma after a course of 810-nm diode laser TTT delivered using the developed methodology

E-mail: inna.sister@gmail.com Background: Immune response is an important factor for efficacy of choroidal melanoma (CM) treatment. Adequate uveal melanoma (UM) organ-saving treatment and treatment efficacy monitoring requires determining the interaction pattern between immune and tumor cells. Purpose: To investigate changes in immune characteristics in patients with small T1 CM (measuring ≤ 3 mm in thickness and ≤ 12 mm in basal dimension) after a course of 810-nm diode laser transpupillary thermotherapy (TTT) delivered using the developed methodology. Materials and Methods: We determined immune system characteristics in 35 patients (9 men (25.7%) and 26 women (24.3%); mean age, 53.9 (12.1) years) with small (T1) CM before and after a course of 810-nm diode laser TTT delivered using the developed methodology. Results: Some characteristics (absolute white blood cell count, absolute and relative CD8+ T cell counts, absolute and relative phagocytic neutrophil activity, absolute and relative CD19+ B cell counts, IgA, IgM, and IgG) decreased, whereas others (relative white blood cell count, absolute and relative CD3+ T cell counts, absolute and relative CD4+ T helper counts, CD4+/CD8+ T-cell ratio, and absolute and relative CD16+ NK cell counts) increased after treatment. However, these changes were not statistically significant, excepting that relating to CD4+/CD8+ T-cell ratio (F=7.9; p = 0.05). Conclusion: 810-nm diode laser transpupillary thermotherapy (TTT) delivered using the developed methodology results in a shift in specific antitumor immune response patterns with a suppression of cytolytic CD8+ T cell response, which requires administering immunocorrective therapy as early as the initial stage of the disease.
Comparison of two cow side tests for diagnosis of subclinical mastitis in cows

Bovine mastitis remains as the major infectious disease that affects dairy cattle throughout the world and results in considerable economic losses to dairy farmers. The present study was undertaken to screen dairy cattle of two organized farms using two cow side tests such as electrical conductivity test and the widely used California Mastitis Test. A total of 261 Quarter milk samples from 77 cows were screened cow side for subclinical mastitis using California Mastitis Test (CMT) and electrical conductivity meter (EC). Correlation between the CMT score and corresponding conductivity was analyzed and the use of EC as an alternative in screening of subclinical mastitis is discussed.
Soccer-related head injuries-analysis of sentinel surveillance data collected by the electronic Canadian Hospitals Injury Reporting and Prevention Program.

Background Participating in sports is a great way to gain physical, psychological, and social benefits. However, it also carries the risk of injury. Soccer is one of the most popular sports worldwide, and in recent years, there have been concerns about potential vulnerabilities to head injuries. Objectives To investigate soccer-related head injuries (SRHIs), using data from the electronic Canadian Hospitals Injury Reporting and Prevention Program (eCHIRPP) surveillance system. Specifically, we aim to compare characteristics of SRHI cases to all head injury cases within the eCHIRPP database. Methods Descriptive analyses of emergency department (ED) injury surveillance data (2011 to 2017) for individuals aged 5 to 29 years from all participating eCHIRPP sites. Computation of proportionate injury ratios (PIR) comparing SRHIs to all head injuries reported to eCHIRPP, and 95% confidence intervals (CI). Results A total of 3,970 SRHIs were reported to eCHIRPP. Injuries were from contact with another player, the ball, ground, goal-post, and other causes. Of the injuries caused by contact with the ball, 9% were from purposely directing the ball with the head (heading). A higher proportion of concussions (PIR=1.32, 95% confidence interval [CI]: 1.27 to 1.37) and minor closed head injuries (PIR=1.20, 95% CI: 1.15 to 1.26) were observed in soccer players. Higher proportions of head injuries occurred in organized soccer and soccer played outdoors. However, admission to the ED for a SRHI was rare (PIR=0.40, 95% CI: 0.30 to 0.55). Conclusions Overall, elevated proportions of brain injuries were observed among soccer players, however, these injuries were unlikely to result in a hospital admission. Moreover, purposely heading the ball contributed to few ED visits.
BBT-877, a Potent Autotaxin Inhibitor in Clinical Development to Treat Idiopathic Pulmonary Fibrosis

RATIONALE Idiopathic Pulmonary Fibrosis (IPF) is a progressive, irreversible and fatal lung disease. Its risk factors include age, genetic and environmental/occupational factors. Currently available therapies only slow down disease progression. Autotaxin (ATX) is an extracellular enzyme involved in the hydrolysis of lysophosphatidylcholine (LPC) to form lysophosphatidic acid (LPA). The ATX – LPA – LPA receptor (LPAR) axis has been suggested to play a pivotal role in the pathogenesis and the progression of IPF. Genetic deletion of ATX, LPAR1 and LPAR2 significantly improved the severity of bleomycin-induced pulmonary fibrosis in mouse. Pharmacological inhibition of ATX and LPAR1 reduced lung fibrosis parameters resulted from the bleomycin treatment in mouse. Positive efficacy data were obtained from clinical trials with drugs targeting the ATX – LPAR pathway.
High-Intensive Interval Training or Supramaximal Interval Training - What to Choose When the Goal is to Improve VO2max and Aerobic Endurance Performance in Females

i Acknowledgment . ii Abbreviations . iv Introduction . 1 Physiological determinants of endurance performance . 1 VO2max. 3 Lactate threshold . 6 Work economy . 6 Anaerobic capacity . 7 Endurance performance . 8 Aim and hypothesis . 10 Method . 11 Subjects . 11 Testing and training procedures . 11 Statistical analysis . 16 Results . 17 Discussion . 23 VO2max. 23 Cardiovascular adaptation . 24 Lactate threshold . 25 Work economy . 26 Anaerobic capacity . 27 Endurance performance . 28 Training considerations . 31 Study limitations . 31 Future research . 32 Conclusion . 32 Reference . 34
Cytological and Wet Mount Microscopic Observations Made in Urine of Schistosoma haematobium-Infected Children: Hint of the Implication in Bladder Cancer

Background Schistosomiasis is the second major human parasitic disease next to malaria, in terms of socioeconomic and public health consequences, especially in sub-Saharan Africa. Schistosoma haematobium (S. haematobium) is a trematode and one of the species of Schistosoma that cause urogenital schistosomiasis (urinary schistosomiasis). Although the knowledge of this disease has improved over the years, there are still endemic areas, with most of the reported cases in Africa, including Ghana. Not much has been done in Ghana to investigate cytological abnormalities in individuals within endemic communities, although there are epidemiologic evidences linking S. haematobium infection with carcinoma of the bladder. Aim The aim of this study was to identify microscopic and cytological abnormalities in the urine deposits of S. haematobium-infected children. Methodology Three hundred and sixty-seven (367) urine samples were collected from school children in Zenu and Weija communities. All the samples were examined microscopically for the presence of S. haematobium eggs, after which the infected samples and controls were processed for cytological investigation. Results S. haematobium ova were present in 66 (18.0%) out of the 367 urine samples. Inflammatory cells (82%, 54/66), hyperkeratosis (47%, 31/66), and squamous cell metaplasia (24%, 16/66) were the main observations made during the cytological examination of the S. haematobium-infected urine samples. Conclusion Cytological abnormalities in S. haematobium-infected children may play an important role in the severity of the disease, leading to the possible development of bladder cancer in later years, if early attention is not given. Therefore, routine cytological screening for urogenital schistosomiasis patients (especially children) at hospitals in S. haematobium-endemic locations is recommended.
Depression and Quality of Life after Cerebral Venous Sinus Thrombosis

Introduction: Cerebral venous sinus thrombosis (CVST) is an important cause of stroke in young and has a favorable outcome. Long-term sequelae of CVST include motor disability, cognitive impairment, depression, anxiety, fatigue, impaired employment and poor quality of life. Objective: To evaluate depression and quality of life after CVST. Methods: Patients who completed at least 1 year after discharge were recruited for this cross-sectional observational study from our CVST cohort. Quality of life was assessed using Stroke-Adapted Sickness Impact Profile (SA-SIP 30) and depression using Hamilton Depression scale (HAM-D). Results: A total of 100 patients (60 men and 40 women) were included in the study. Their age ranged from 14 to 60 years (34.97 ± 10.06). The interval from discharge to assessment of quality of life was 2.2 ± 1.6 years. In all, 98% of patients had good modified Rankin score at follow-up. SA-SIP 30 did not reveal any functional disability for physical functioning. Seven had impairment for psychosocial domain despite having good modified Rankin scores. Thirty patients had depression. Patients with higher mRS at discharge had increased presence of depression. Quality-of-life scores did not correlate with presence of seizure, headache, infarction and sinuses involved. Conclusion: This is the first Indian study demonstrating depression in patients with CVST and use of SA-SIP to assess quality of life in them. Occurrence of depression in CVST is as high as in arterial strokes.
The Impact of Education and Feedback on the Accuracy of Pressure Injury Staging and Documentation by Bedside Nurses

Background: Pressure Injuries (PIs) are largely preventable. Accurate documentation of PI stage or progression is a key quality measure. Local Problem: Nurses frequently fail to accurately assess and document their findings in the electronic medical record. This project sought to increase nurses’ knowledge and accuracy of staging and documentation of PIs. Method: Educational interventions; direct observation of PI status; review of nurse documentation; feedback,;and referrals to wound, ostomy, and continence nurses (WOCNs). Interventions: Nurses completed a pre- and post-test and online training modules, and participated in training sessions. Clinical experts completed direct skin observations and provided feedback about PI staging. Results: There was a statistically significant improvement in nurses’ knowledge about PIs (p = 0.004). Skin assessments were conducted on 108 patients (13 PIs identified). The bedside nurse accurately assessed a PI stage in only 31% of these observations. Referrals to WOCNs increased by 18% compared to the baseline period. Conclusions: Educational interventions enhanced nurses’ knowledge; however, appropriate PI staging may require skills development and validation to build competency. Keywords: pressure injury, pressureulcer,wound care, prevention, evidence-based practice, prevalence, assessment, documentation, education
Efficacy of ginkgo biloba extract as augmentation of venlafaxine in treating post-stroke depression

Background Post-stroke depression (PSD) is one of the most common psychiatric diseases afflicting stroke survivors. This study was conducted to assess the efficacy of ginkgo biloba extract as augmentation of venlafaxine in treating PSD. Methods The included PSD patients were randomly assigned into the experiment group (receiving ginkgo biloba extract plus venlafaxine) and control group (receiving venlafaxine alone). The treatment was continued for eight weeks. The Hamilton Depression Rating Scale (HDRS) and the Self-rating Depression Scale (SDS) were used to assess the depressive symptoms. The National Institutes of Health Stroke Scale (NIHSS) was used to assess the neurological defect, and the Activities of Daily Living (ADL) was used to assess recovery of abilities of patients after stroke. Meanwhile, the levels of serum 5-hydroxytryptamine (5-HT) and brain-derived neurotrophic factor (BDNF) were measured before and after treatment. The dose of venlafaxine used and adverse events were also recorded. Results Each group had 40 PSD patients. After treatment, the depressive symptoms, neurological defect and living function were significantly improved in both groups. But the patients receiving ginkgo biloba extract plus venlafaxine had the significantly lower average HDRS score (p=0.0008), SDS score (p<0.00001), NIHSS score (p=0.00001), and higher average ADL score (p=0.0005). Meanwhile, compared to the control group, patients in the experiment group had the significantly higher 5-HT (p<0.00001) level and BDNF level (p<0.00001), needed lower dose of venlafaxine (p=0.007), and experienced fewer adverse events. Conclusion These results demonstrated that the ginkgo biloba extract was a good augmentation of venlafaxine in treating PSD and should be further investigated.
Assessment of Autologous (Platelet-Rich-Plasma) as A Monotherapy for Treatment of Dry Eye Disease

Background: treatment of dry eye disease (DED) depends on minimizing inflammation and improving various components of the tear film. Artificial tears remain an important part of patient comfort, with many lipid- and gelbased formulations for a healthy ocular surface. Objective: the work aimed to evaluate the role of autologous platelet-rich plasma (PRP) as a monotherapy for treatment of dry eye disease, versus artificial tears use. Patients and Methods: a prospective comparative study. The study included 55 eyes of 30 patients with moderate to severe dry eye disease. The study was performed at Ophthalmology Department in Alazhar University Hospitals. Results: in our study PRP group of patients all are improved in all parameters and all of them were statistically significant. Symptoms OSDI score decreased indicating improvement in 86.6% of patients. TBUT improved in 66.6% of cases. CFS improved up to disappearance of staining in 33% of cases and fair improvement in 53.3%, total improvement was 86.6%. Schirmer test improved in 40% of cases. BCVA improved in 26.6% of patients, improvement was not more than one line. Conclusion: PRP is very effective in treatment of moderate and severe cases of DED at the level of subjective symptoms, TBUT, CFS, BCVA, and Schirmer test.