Miracle-dz/UniFAR-FTUs huggingface dataset:
Type 3 ILCs in Lung Disease

The lungs represent a complex immune setting, balancing external environmental signals with a poised immune response that must protect from infection, mediate tissue repair, and maintain lung function. Innate lymphoid cells (ILCs) play a central role in tissue repair and homeostasis, and mediate protective immunity in a variety of mucosal tissues, including the lung. All three ILC subsets are present in the airways of both mice and humans; and ILC2s shown to have pivotal roles in asthma, airway hyper-responsiveness, and parasitic worm infection. The involvement of ILC3s in respiratory diseases is less well-defined, but they are known to be critical in homeostasis, infection and inflammation at other mucosal barriers, such as the gut. Moreover, they are important players in the IL17/IL22 axis, which is key to lung health. In this review, we discuss the emerging role of ILC3s in the context of infectious and inflammatory lung diseases, with a focus on data from human subjects.
LAYN Is a Prognostic Biomarker and Correlated With Immune Infiltrates in Gastric and Colon Cancers

Background: Layilin (LAYN) is a critical gene that regulates T cell function. However, the correlations of LAYN to prognosis and tumor-infiltrating lymphocytes in different cancers remain unclear. Methods: LAYN expression was analyzed via the Oncomine database and Tumor Immune Estimation Resource (TIMER) site. We evaluated the influence of LAYN on clinical prognosis using Kaplan-Meier plotter, the PrognoScan database and Gene Expression Profiling Interactive Analysis (GEPIA). The correlations between LAYN and cancer immune infiltrates was investigated via TIMER. In addition, correlations between LAYN expression and gene marker sets of immune infiltrates were analyzed by TIMER and GEPIA. Results: A cohort (GSE17536) of colorectal cancer patients showed that high LAYN expression was associated with poorer overall survival (OS), disease-specific survival (DSS), and disease-free survival (DFS). In addition, high LAYN expression was significantly correlated with poor OS and progression-free survival (PFS) in gastric cancers (OS HR = 1.97, P = 3.6e-10; PFS HR = 2.12, P = 2.3e-10). Moreover, LAYN significantly impacts the prognosis of diverse cancers via The Cancer Genome Atlas (TCGA). Specifically, high LAYN expression was correlated with worse OS and PFS in stage 2 to 4 but not stage 1 and stage N0 gastric cancer patients (P = 0.28, 0.34; P = 0.073, 0.092). LAYN expression was positively correlated with infiltrating levels of CD4+ T and CD8+ T cells, macrophages, neutrophils, and dendritic cells (DCs) in colon adenocarcinoma (COAD) and stomach adenocarcinoma (STAD). LAYN expression showed strong correlations with diverse immune marker sets in COAD and STAD. Conclusions: These findings suggest that LAYN is correlated with prognosis and immune infiltrating levels of, including those of CD8+ T cells, CD4+ T cells, macrophages, neutrophils, and DCs in multiple cancers, especially in colon and gastric cancer patients. In addition, LAYN expression potentially contributes to regulation of tumor-associated macrophages (TAMs), DCs, T cell exhaustion and Tregs in colon and gastric cancer. These findings suggest that LAYN can be used as a prognostic biomarker for determining prognosis and immune infiltration in gastric and colon cancers.
Antidepressant Effects of Repetitive Transcranial Magnetic Stimulation Over Prefrontal Cortex of Parkinson's Disease Patients With Depression: A Meta-Analysis

Objective: The purpose of this meta-analysis was to investigate the antidepressant effects of repetitive transcranial magnetic stimulation (rTMS) over the prefrontal cortex (PFC) of patients with Parkinson's disease (PD) and to determine the optimal rTMS parameters, such as the intensity, frequency and the delivered pattern of rTMS stimulation. Methods: EMBASE, PubMed, Web of Science, MEDLINE, and Cochrane data bases were researched for papers published before March 12, 2018. Studies investigating the anti-depression effects of rTMS over PFC in patients with PD were considered. The main outcomes of pre- and post-rTMS treatment as well as score changes were all extracted. The mean effect size was estimated by calculating the standardized mean difference (SMD) with 95% confidence interval (CI) by using fixed or random effect models as appropriate. Results: Nine studies containing 137 PD patients with depression were included. The pooled results showed significant pre-post anti-depressive effects of rTMS over PFC in PD patients with depression (SMD = −0.80, P < 0.00001). The subgroup analyses of stimulation intensity, frequencies, and models also revealed significant effects (Intensities: 90% RMT: SMD = −1.16, P = 0.0006; >100% RMT: SMD = −0.82, P < 0.0001. Frequencies: < 1.0 Hz: SMD = −0.83, P = 0.03; 5.0 Hz: SMD = −1.10, P < 0.0001; ≥10.0 Hz: SMD = −0.55, P = 0.02. Models: Continuous: SMD = −0.79, P < 0.0001; Discontinuous: SMD = −0.84, P = 0.02). But the results of the studies with place-controlled designs were not significant (Overall: SMD = −0.27, P = 0.54. Intensities: 90% RMT: SMD = 0.27, P = 0.68; 100% RMT: SMD = −0.32, P = 0.33. Frequencies: 5.0 Hz: SMD = −0.87, P = 0.10; ≥10.0 Hz: SMD = 0.27, P = 0.66. Models: Continuous: SMD = −0.28, P = 0.68; Discontinuous: SMD = −0.32, P = 0.33). The greater effect sizes of rTMS with 90% RMT, 5.0 Hz in discontinuous days can be observed rather than the other parameters in both kinds of analyses across study design. Conclusions: rTMS may have a significant positive pre-post anti-depressive effect over PFC on patients with depression, especially by using 5.0 Hz frequency with 90% RMT intensity in discontinuous days, which may produce better effects than other parameters. The real effect, though, was not different from that of the placebo. Future studies with larger sample sizes and high-quality studies are needed to further corroborate our results and to identify the optimal rTMS protocols.
Family environments of parenting and nonpregnant/nonparenting teens

The purpose of this study was to examine the differences in family environments between parenting teens and nonpregnant/nonparenting teens. Parenting teens (N = 56) and nonpregnant/nonparenting nominated friends (N = 27) responded to paper and pencil questionnaires and open-ended questions concerning background characteristics, family environments, self esteem, verbal ability, birth control use, and motherdaughter relationships. T-test analyses indicated that friends were older, more highly educated, and reared more often in intact families than the parenting teens; friends also had a higher self esteem, higher GPAs, more financial aid sources, and attended church more regularly than parenting teens. Furthermore, the nominated friends had friendships of longer duration, felt influenced by friends concerning sexual activity and contraceptive use, and had more pregnant friends in the past than the parenting teens. Friends were more likely not to entertain ideas of being a teen parent. A regression analysis indicated that pregnancy was predicted by lower levels of family cohesion, higher self esteem, lower educational levels in teens, and having a mother who was younger at the birth of her first baby. Descriptive statistics indicated that teens mentioned the following aspects as either ways in which they would be similar or different from their parents in childrearing: family milieu,
Eye check practice among non ophthalmic doctors in a tertiary centre

Aims: To evaluate the practice of eye check among non oph thalmic doctors and the possible factors influencin g such practice in a tertiary health centre in Ekiti State. Materials and methods: A cross-sectional descriptive study conducted at Ekiti state university teaching hospit al Ado Ekiti between January 2014 and April 2014 am ong nonophthalmic doctors in the health institution. All t he consenting doctors were interviewed with pre-tes ted selfadministered questionnaires. Data were analysed usi ng SPSS 20. Results: A total of 125 non ophthalmic doctors participated in the study. Seventy four (59.2%) ha ve had their eyes checked by ophthalmologists while the remaining 40.8% (P=.011) had not done so in their e nti e life. Eighty percent of those who have pract ised medicine for more than 10 years compared with 51.1% of thos e with less than 10 years of practice had their ey es checked by ophthalmologists(P=.003). A small proportion (8.1%) of these doctors had never had an eye checked desp ite u ing glasses. Conclusion: Routine eye check practice was low among these non ophthalmic doctors especially the younger and less experienced ones. Most eye checks were consequent to eye complaints.
Recurrent Pneumonia in Children Admitted to Assiut University Children Hospital. Magnitude of the Problem and Possible Risk Factors

Background: Incidence data indicate that recurrent pneumonia occurs in 7.7–9% of all children with community acquired pneumonia. We aim by this study to assess the prevalence of recurrent pneumonia among the admissions with diagnosis of pneumonia in Assiut university children hospital for one year and to try to define the possible related risk factors. Patients and methods: This is a prospective hospital based study in Assiut University Children’s Hospital. Children younger than 16 years admitted with a hospital diagnosis of pneumonia to Assiut University Children’s Hospital for one year from 1 February 2017 to 31 January 2018 were included. Results: Approximately 1 in 12 children with pneumonia in our locality have recurrent pneumonia with percentage of 12.61%. Cardiac diseases especially congenital heart diseases was the cause among 25.45% of the cases, immunodeficiency diseases represented 20.9% of the cases ,while bronchial asthma was the cause of recurrent pneumonia among 16.36% of the cases. As regard to risk factors in studied group, prematurity was detected among 7.27 % of the cases while more than 50% were formula fed and more than 60% exposed to pollution. Father smoking was detected among 36.36% of cases. Patients aged > 6 years showed significantly higher frequency in risk factors as obesity, indoor and outdoor pollution and use of steroids in comparison to other age groups. However, patients aged 0-3 years exhibited significantly higher % frequency of having heart disease, oro-motor in coordination /swallowing dysfunction, gastro esophageal reflux and under nutrition as risk factors for recurrent pneumonia in comparison to other age groups. Conclusions: The most frequent underlying cause for recurrent pneumonia in Assiut University Children’s Hospital which presents the largest referral pediatric hospital in Upper Egypt for one year according to our study was cardiac diseases; the second most frequent cause was immunodeficiency diseases, followed by bronchial asthma. Risk factors for recurrent pneumonia include socio-economic status of studied cases, prematurity, exposure to passive smoking and in or outdoor pollution, obesity, under nutrition, lack of breast feeding, gastro esophageal reflux and steroids usage.
The Tsunami's CSR Effect: Mnes and Philanthropic Responses to the Disaster

This paper contributes to the literature on CSR and International Business by linking firm internationalization to corporate philanthropy. Considering the 2004 Tsunami disaster as a highly relevant case of an international societal issue, we analyze the characteristics of the corporate response to the disaster among Fortune Global 500 firms. We find that home region, degree of internationalization, firm size and profitability most strongly influenced the propensity of firms to donate as well as the value of their donations.
Relation of Breast Milk Adiponectin Level to Infant Growth

Background: Studies on the physiology of breastfeeding revealed the presence of the adipokines as adiponectin in mothers’ milk. In full-term neonates, during the first few days of life, serum and plasma adiponectin levels correlate positively with birth weight and length, neonatal adiposity. While, circulating adiponectin levels correlate negatively with the degree of adiposity in children aged between 5 and 10 years. Patient and Methods: In the current cross sectional study patients and their mother were recruited from out patient clinic in Ain Shams Hospital. Questionnaire was done for maternal age, maternal diseases, gestational age, mode of delivery, infant sex and type of feeding. Also in this study maternal body mass index and infant anthropometry were calculated and breast milk adiponectin levels were measured at 1st week, one month and at six months. Results: Maternal body mass index ranges from (19-29). Infant weight z-score ranges were (-1.77-1.84), (-1.76-1.9) and (-2.02-1.62) at one week, one month and six months respectively. Infant length z-score ranges were (-1.45-2.72), (1.43-3.01) and (-1.61-1.54) at one week, one month and six months respectively. Breast milk adiponectin ranges were (12.8-38.4 ng/dl), (8.8-30.8 ng/dl) and (5.5-25 ng/dl) at one week, one month and six months respectively. Conclusion: The results of the present study confirm that human milk adiponectin was significantly associated with lower infant WAZ score at one month, with high significant association with lower infant WAZ score at six month. However, not associated with infant weight at baseline.
Testing Day of the Week Effect on Precious Metals Market

Market efficiency assumes that asset prices should be characterized by randomness and unpredictability, so that potential market participants are not able to generate above-average profits. This means that there should be no seasonal phenomenon in time series, which clearly projects a certain pattern of behavior of financial assets. The paper is an attempts to verify some specific seasonal effect called “the day of the week” on the precious metals market. The selection of this area is not accidental. Precious metals are an alternative to classic capital investments, especially in the case of financial and economic crises. In addition, the literature shows a gap in this area in terms of dynamics analysis on commodity markets, if compared to capital market. The analysis of day of the week effect was carried out taking into account both conditional mean and conditional variance. Results are not clear and strongly depends on the type of precious metal.
Posthorax ® Prevents Sternal Dehiscence and Instability: Preliminary Results of a Prospective Randomized Multicenter Trial

Aim: A Prospective Randomized Multicenter Trial is ongoing to evaluate Posthorax and prevention of sternal dehiscence/instability: clinical percept is optimistic for Posthorax use. The aim of this mono-center analysis is to give a preliminary result of Posthorax support vest after sternotomy. Methods: One hundred and eighty three cases elective patients were consecutive operated and included in this study conducted in our department since June 2009. Patients were randomized as following: 68 patients were treated with the Posthorax support vest and 115 received a standard bandage postoperatively. The primary endpoints were the Infective Events. Secondary endpoints included a composite of postoperative clinical variables and mortality. Results: The two groups are homogeneous for these characteristic except sex (more women in Control Group, p = 0.022). Operative data were comparable in both groups. Deep sternal infections occurred in four patients, all in Control Group (3.5% vs 0%, p = 0.153). At Follow up, we recorded 2 cases of superficial infection in the control group versus 0 (1.7%, p = 0.394) and 1 case of wound dehiscence always in Control Group versus 0 (0.9%, p = 0.628). Cumulative Infective Events are statistically more in Control Group (7 cases 6.1% versus 0 cases, p = 0.036*). According to the secondary endpoints, there were also no differences between the two compared groups except length of hospitalization (10.6 ± 4 days versus 13.4 ± 9.5, p = 0.019*). Conclusion: Preliminary results show the Posthorax sternum support vest as a valuable adjunct to prevent sternum-related complications: We record a statistical reduction of length of hospital stay and infective events using the support vest in a 3-month follow-up.
BRITISH JOURNAL OF INDUSTRIAL MEDICINE

But in the process it has gone on to develop two pointsthe restriction of comment to the limited and particular group of the moment, and the independence of the research team-which surely are matters of research tactics, into principles which have guided and confined the entire study within the restricted bounds already described, and without which, its considerable value would have been still more enhanced. It will of course be obvious that these remarks are to be taken in their context-of gratitude that here at last is a serious and indeed pioneering study of some of the least accessible features of human relations in industry. D. H. ALLCORN
Ultrasound guidance versus transillumination for peripheral intravenous cannulation in pediatric patients with difficult venous access

Objective Venous access can be technically difficult in pediatric patients because of the small size and impalpability of their veins. The aim of this prospective randomized study was to compare the use of ultrasound (US) guidance and transillumination as aids to facilitate peripheral intravenous cannulation in pediatric patients with difficult venous access. Patients and methods We included 80 children, less than 6 years of age, undergoing elective surgery, and having difficult venous access as predicted by a Difficult Intravenous Access score of at least 4. The patients were randomized to either US guidance (the US group, n = 40) or transillumination using the Veinlite EMS (the Veinlite group, n = 40). Cannulation was performed after inhalation induction of anesthesia. The primary outcome measure was the first-attempt success rate of cannulation. The secondary outcome measures were the overall success rate of cannulation, number of attempts, and time required to achieve successful cannulation. Results The first-attempt success rate was significantly higher in the US group (82.5%) compared with the Veinlite group (57.5%, P < 0.05). Both groups showed a high overall success rate (92.5% in the US group and 80% in the Veinlite group, P = 0.19). The time to achieve successful cannulation was significantly shorter in the US group (67.1 ± 19.3 s) than in the Veinlite group (94.1 ± 49.9 s, P < 0.01). The number of attempts required was not significantly different between the two groups. Conclusion Both US guidance and transillumination facilitate peripheral intravenous cannulation in pediatric patients with difficult venous access, resulting in a high overall success rate of cannulation. US guidance is superior as it results in a higher first-attempt success rate with less time required to achieve successful cannulation compared with transillumination.
Insulin Resistance in Apparently Healthy Adult Nigerians: Association with Magnesium Status

Magnesium plays a critical role in glucose metabolism and evidences suggest that magnesium deficiency is associated with decreased insulin sensitivity. However, it is likely that these relationships are affected by genetic and environmental factors that can differ among different populations. The aim of this study was to determine the prevalence of insulin resistance and its association with magnesium status among apparently healthy adult Nigerians. Fasting plasma levels of magnesium, glucose and insulin were determined in 120 apparently healthy adults. Insulin resistance was calculated as HOMA-IR. Prevalence of insulin resistance was estimated and the association between plasma magnesium levels and HOMA-IR was determined. About 19.2% of the study subjects were classified as having insulin resistance. Prevalence was higher among males compared to females (21.0% vs. 17.0%) and among obese compared to normal weight subjects (26.1% vs. 14.9%). Subjects with hypomagnesemia had higher prevalence of insulin resistance compared with subjects who had normal plasma magnesium levels (50.0% vs. 14.4%). Insulin resistance was inversely associated with plasma magnesium level independent of age, gender and BMI. Insulin resistance is relatively common among apparently healthy individuals in this study. Magnesium deficiency was found to be a significant predictor of insulin resistance. We recommend further studies that will investigate whether optimization of magnesium status in general population or among individuals at risk of developing type 2 diabetes will be a useful approach in lowering insulin resistance and prevent or delay onset of type 2 diabetes mellitus in our setting.
Understanding the therapeutic alliance between nurses and consumers with anorexia nervosa in the context of the inpatient setting : a mixed methods study

x Chapter One: Introduction . 1 The Need for Evidence . 2 Therapeutic Alliance . 3 Originality of Research . 4 Summary . 5 Dissertation Structure . 5 Key Terms . 7 Chapter Two: Therapeutic Alliance . 9 Introduction . 9 Therapeutic Alliance: A Psychoanalytic Concept . 9 Summary of the Contemporary Dyadic Alliance . 13 Nursing and Therapeutic Alliance . 14 The Interpersonal History of Nursing . 15 Contemporary Nursing and Therapeutic Alliance . 19 A Revolution in Mental Healthcare . 21 Recovery . 23 Therapeutic Alliance and Contextual Implications . 25 Therapeutic Alliance and Contextual Correspondence . 26 Cross Disciplinary Comparison . 26 Therapeutic Alliance in the Dyad and in Nursing . 27 Therapeutic Alliance and Contextual Variation . 29 Ward Context: atmosphere and milieu . 31 Summary . 31 Chapter Three: Anorexia Nervosa and Therapeutic Alliance. 33 Introduction . 33 Anorexia Nervosa . 33 Contemporary Definition . 34
Enabling Reproducible Research in Sensor-Based Transportation Mode Recognition With the Sussex-Huawei Dataset

Transportation and locomotion mode recognition from multimodal smartphone sensors is useful for providing just-in-time context-aware assistance. However, the field is currently held back by the lack of standardized datasets, recognition tasks, and evaluation criteria. Currently, the recognition methods are often tested on the ad hoc datasets acquired for one-off recognition problems and with different choices of sensors. This prevents a systematic comparative evaluation of methods within and across research groups. Our goal is to address these issues by: 1) introducing a publicly available, large-scale dataset for transportation and locomotion mode recognition from multimodal smartphone sensors; 2) suggesting 12 reference recognition scenarios, which are a superset of the tasks we identified in the related work; 3) suggesting relevant combinations of sensors to use based on energy considerations among accelerometer, gyroscope, magnetometer, and global positioning system sensors; and 4) defining precise evaluation criteria, including training and testing sets, evaluation measures, and user-independent and sensor-placement independent evaluations. Based on this, we report a systematic study of the relevance of statistical and frequency features based on the information theoretical criteria to inform recognition systems. We then systematically report the reference performance obtained on all the identified recognition scenarios using a machine-learning recognition pipeline. The extent of this analysis and the clear definition of the recognition tasks enable future researchers to evaluate their own methods in a comparable manner, thus contributing to further advances in the field. The dataset and the code are available online.11http://www.shl-dataset.org/