Miracle-dz/UniFAR-FTUs huggingface dataset:
Spectrum of hysterosalpingographic findings among women presenting with infertility in Abuja, Nigeria’s capital

Background: Hysterosalpingography HSG provides the outline of the endometrial canal and fallopian tubes and is an invaluable imaging modality in the investigative management of infertility especially in resource challenged environments. The objective of the study was to review the hysterosalpingographic (HSG) findings in women investigated for infertility in Abuja, Nigeria’s capital. Methods: This is a descriptive review of retrospective radiologic reports of 219 patients who underwent HSG as part of infertility investigation over a three-year period (2013-2015) in University of Abuja teaching Hospital. Results: A total of 219 reports were reviewed with age range of 20-53years (mean 33.9 ±5.7 2SD) years. Majority were between the ages of 26-37 years (n=102, 33.6%). Secondary infertility was the indication in 172 (78.5%) and primary infertility in 47 (21.5%). Majority of the women (n=149, 68%) had hysterosalpingographic abnormalities with Tuboperitoneal pathology as the prevalent finding in 112 (75.2%) of the cases either as a single pathology or coexisting with intrauterine abnormality. The most common endometrial cavity abnormality was uterine Fibroid seen in 53, (35.6%) women. Conclusions: Hysterosalpingography remains very important in the investigation of infertility in our center with tuboperitoneal pathology as the major contributor to female infertility.
Onset of angioedema following a viper bite: different options for diagnostic procedure in an emergency department

The unexpected onset of an angioedema in a patient observed in the emergency department after a viper bite, gave the opportunity to consider some different etiopathogenetic hypothesis and to discuss the most correct diagnostic procedure. The patient was a 60-year-old man who was treated with sartans for hypertension and reported a recent diagnosis of monoclonal gammopathy of uncertain significance. Based on the patient history and on the clinical aspects of the angioedema, the authors consider the possibility of an acquired non-allergic angioedema and its probable close relationship with a lymphoproliferative disorder.
Clinical relevance of genomic signatures of type 2 inflammation in chronic obstructive pulmonary disease

[3] reported on a ‘COPD-like’ small airway epithelial transcriptome; by identifying differentially expressed genes they could classify clinically healthy smokers into subgroups with lesser and greater responses to cigarette smoking. Following these results, whole-genome gene expression profiling done on bronchial biopsies from COPD patients treated with inhaled corticosteroids (ICS) in the GLUCOLD study, [4] showed
Hypoglycemia in unmonitored full-term newborns-a surveillance study.

Background and objectives Hypoglycemia monitoring is not recommended for most full-term newborns. We wished to determine the incidence, presentation and case characteristics of hypoglycemia in low-risk newborns. Methods With the assistance of the Canadian Paediatric Surveillance Program, we conducted a national study of severe hypoglycemia in apparently low-risk full-term newborns. Paediatricians who reported a case were sent a detailed questionnaire and the data were analyzed. Results All 93 confirmed cases were singletons, 56% were first-borns and 65% were male. An 8% rate of First Nations cases was twofold the population rate. Maternal hypertension rate was 23%, fourfold the general pregnancy rate. Maternal obesity was double the general pregnancy rate at 23%. Concerning signs or feeding issues were noted in 98% at the time of diagnosis. Median time to diagnosis was 4.1 hours. Mean blood glucose at intravenous (IV) start was 1.4 ± 0.5 hours (SD). Seventy-eight per cent had at least one of four potential stress indicators and were more likely to have early diagnosis (P=0.03). Major signs were present in 20%. Those cases presented later and had lower glucose levels (median=0.8 mmol/L versus 1.6 mmol/L, [P<0.001). Twenty-five per cent of cases had birth weight less than the 10th centile. Neurodevelopmental concern was reported in 20%. Of the 13 cases which had brain magnetic resonance imaging, 11 were abnormal. Conclusion Hypoglycemia in unmonitored newborns is uncommon but is associated with significant morbidity. We provide a range of clues to help identify these newborns soon after birth. Widespread adoption of norm-based standards to identify small-for-gestational age infants is supported.
Applying the Delphi method to generate interventions to reduce unnecessary interruptions in clinical nursing

The objective of this study was to describe a panel process of selecting interventions to reduce unnecessary interruptions in clinical nursing. Interruptions in nursing may jeopardise patient safety, disorganise planning, and lead to ineffective working procedures. The Delphi panel process may be useful to create consensus on interventions to reduce interruptions. Using the Delphi method, a structured group-based decision-making tool, a panel of 14 nurses agreed on interventions to reduce interruptions. The results showed that a consensus on reducing interruptions was reached in four focus areas: expectations, physical framework, work procedures, and medication room procedures. The panel process was chosen as a means to involve nursing staff to create consensus and ownership about interventions. Our conclusions are that the Delphi panel process was a feasible method of selecting multi-factorial interventions to reduce interruptions. The panel process contributed to dialogue, staff involvement, and competency development. Further prospective studies are needed to explore whether these multi-factorial interventions can reduce unnecessary interruptions and improve patient safety.
Therapeutic effects of traditional Korean medicine, Jeechool-Whan in allergic rhinitis model

Jeechool-Whan (JW) is a prescription of Ponciri Fructus Immaturus and Atractylodis Rhizoma Alba and improves the functions of the stomach and the spleen. Although it is said in Korean Medicine that the spleen and the stomach are the roots of the body"s resistance, the meaning of "improving the spleen and the stomach" is very comprehensive. Moreover, there are lots of drugs that are said to improve the spleen and the stomach, and the number of prescriptions using these drugs is huge. In this study, we focused on the new effect and mechanism of the JW on the ovalbumin (OVA)-induced allergic rhinitis (AR) model. The increased number of rubs and the increased levels of IgE and histamine in the OVA-sensitized mice were inhibited by JW administration. The balance of Th1/Th2 cytokine level was regulated by JW administration. The levels inflammatory proteins were decreased by JW administration in the nasal mucosa of the OVA-sensitized mice. Eosinophils and mast cells infiltration increased by OVAsensitization was also decreased in the JW-administered mice. In addition, JW inhibited caspase-1 activity in the same nasal mucosa tissue. In activated human mast cells, JW inhibited the receptor interacting protein-2, IκB kinase-β, nuclear factor-κB/Rel A, and caspase-1 activation. In conclusion, this study will be support the clear understanding of the concept of the spleen and the stomach in traditional Korean medicine as well as for a possibility of finding a cure for this AR in traditional medical treatments.
Thiamethoxam, Clothianidin, and Imidacloprid Seed Treatments Effectively Control Thrips on Corn Under Field Conditions

Abstract With the widespread adoption of no-tillage technology, outbreaks of thrips have caused serious damage to summer corn fields in China. Therefore, effective control of pest populations is often essential for cost-effective crop production. In this study, experiments were conducted in 2014 and 2015 to determine the control efficacy of seven neonicotinoid insecticide seed treatments against corn thrips and the effects of these treatments on natural enemy population densities and emergence rates, seedling characteristics, and yield of corn. The results showed that among the tested neonicotinoid seed treatments, thiamethoxam (1.0 and 2.0 g active ingredient (AI)/kg of seeds), clothianidin (1.0 and 2.0 g AI/kg of seeds), and imidacloprid (2.0 g AI/kg of seeds) showed the highest control efficacy against corn thrips throughout the corn growing season. Seed treatments with acetamiprid, nitenpyram, dinotefuran, and thiacloprid at rates of 1.0 and 2.0 g AI/kg of seeds were difficult to effectively control thrips on summer corn. Neonicotinoid seed treatments showed no adverse effects on the numbers of spiders and lady beetles. Furthermore, treatments did not negatively influence the seedling growth or development of corn but did prevent yield losses. Therefore, treating corn seeds with thiamethoxam, clothianidin, and imidacloprid can provide effective protection against early-season thrips and reduce yield losses under field conditions.
Does persistent snowpack inhibit degradation of fecal stress indicators?

Stress can be measured non-invasively for free-ranging animals using fecal hormone metabolites. However, fecal samples subject to warm temperatures, wet conditions, or freeze-thaw cycles are liable to degrade. Our results suggest that samples deposited on a persistent snowpack may provide reliable measurements for up to 10 days.
Osteoclast-like giant cell tumor of the pancreas—an unusual presentation in a patient with large mantle cell lymphoma

Abstract Osteoclast-like giant cell tumor of the pancreas is very rare. We report a 78-year-old male who was previously treated for large mantle cell lymphoma, was found to have an increased uptake in a peri-pancreatic node from his restaging PET scan. Endoscopic ultrasound-directed fine-needle aspiration of the mass and lymph node revealed an undifferentiated carcinoma with osteoclast-like giant cells. Osteoclast-like giant cell tumors of the pancreas are frequently found to be unresectable at diagnosis due to their large size (>5 cm). In our patient, due to its small size (<3 cm) sub-total pancreatectomy was performed. Three years from the surgery, the patient is doing well without recurrence. This case report intends to increase provider awareness that in the setting of new pancreatic lesions in a patient with previous history of lymphoma, a high index of suspicion for a primary pancreatic lesion should be included in the differential diagnosis.
Right hemisphere superiority for executive control of attention

Over forty years have passed since the first evidence showing the unbalanced attentional allocation of humans across the two visual fields, and since then, a wealth of behavioral, neurophysiological, and clinical data increasingly showed a right hemisphere dominance for orienting of attention. However, inconsistent evidence exists regarding the right-hemisphere dominance for executive control of attention, possibly due to a lack of consideration of its dynamics with the alerting and orienting functions. In this study, we used a version of the Attentional Network Test with lateralized presentation of the stimuli to the left visual field (processed by the right hemisphere, RH) and right visual field (processed by the left hemisphere, LH) to examine visual field differences in executive control of attention under conditions of alerting or orienting. Analyses of behavioral performance (reaction time and error rate) showed a more efficient executive control (reduced conflict effect) in the RH compared to the LH for the reaction time, under conditions of increased alerting and of informative spatial orienting. These results demonstrate the right-hemisphere superiority for executive control, and that this effect depends on the activation of the alerting and orienting functions.
Health workers' experiences of collaborative quality improvement for maternal and newborn care in rural Tanzanian health facilities: A process evaluation using the integrated 'Promoting Action on Research Implementation in Health Services' framework

Background Quality Improvement (QI) approaches are increasingly used to bridge the quality gap in maternal and newborn care (MNC) in Sub Saharan Africa. Health workers typically serve as both recipients and implementers of QI activities; their understanding, motivation, and level of involvement largely determining the potential effect. In support of efforts to harmonise and integrate the various QI approaches implemented in parallel in Tanzanian health facilities, our objective was to investigate how different components of a collaborative QI intervention were understood and experienced by health workers, and therefore contributed positively to its mechanisms of effect. Materials and methods A qualitative process evaluation of a collaborative QI intervention for MNC in rural Tanzania was carried out. Semi-structured interviews were conducted with 16 health workers in 13 purposively sampled health facilities. A deductive theory-driven qualitative content analysis was employed using the integrated Promoting Action on Research Implementation in Health services (i-PARIHS) framework as a lens with its four constructs innovation, recipients, facilitation, and context as guiding themes. Results Health workers valued the high degree of fit between QI topics and their everyday practice and appreciated the intervention’s comprehensive approach. The use of run-charts to monitor progress was well understood and experienced as motivating. The importance and positive experience of on-site mentoring and coaching visits to individual health facilities was expressed by the majority of health workers. Many described the parallel implementation of various health programs as a challenge. Conclusion Components of QI approaches that are well understood and experienced as supportive by health workers in everyday practice may enhance mechanisms of effect and result in more significant change. A focus on such components may also guide harmonisation, to avoid duplication and the implementation of parallel programs, and country ownership of QI approaches in resource limited settings.
New Developments on the Adenosine Mechanisms of the Central Effects of Caffeine and Their Implications for Neuropsychiatric Disorders

Recent studies on interactions between striatal adenosine and dopamine and one of its main targets, the adenosine A2A receptor–dopamine D2 receptor (A2AR–D2R) heteromer, have provided a better understanding of the mechanisms involved in the psychostimulant effects of caffeine and have brought forward new data on the mechanisms of operation of classical orthosteric ligands within G protein-coupled receptor heteromers. The striatal A2AR–D2R heteromer has a tetrameric structure and forms part of a signaling complex that includes a Gs and a Gi protein and the effector adenyl cyclase (subtype AC5). Another target of caffeine, the adenosine A1 receptor–dopamine D1 receptor (A1R–D1R) heteromer, seems to have a very similar structure. Initially suggested to be localized in the striatum, the A1R–D1R heteromer has now been identified in the spinal motoneuron and shown to mediate the spinally generated caffeine-induced locomotion. In this study, we review the recently discovered properties of A2AR–D2R and A1R–D1R heteromers. Our studies demonstrate that these complexes are a necessary condition to sustain the canonical antagonistic interaction between a Gs-coupled receptor (A2AR or D1R) and a Gi-coupled receptor (D2R or A1R) at the adenylyl cyclase level, which constitutes a new concept in the field of G protein-coupled receptor physiology and pharmacology. A2AR antagonists targeting the striatal A2AR–D2R heteromer are already being considered as therapeutic agents in Parkinson's disease. In this study, we review the preclinical evidence that indicates that caffeine and A2AR antagonists could be used to treat the motivational symptoms of depression and attention-deficit/hyperactivity disorder, while A1R antagonists selectively targeting the spinal A1R–D1R heteromer could be used in the recovery of spinal cord injury.
Guiding the humoral response against HIV-1 toward a MPER adjacent region by immunization with a VLP-formulated antibody-selected envelope variant

Preventive HIV-1 vaccine strategies rely on the elicitation of broadly neutralizing antibody (bNAb) responses, but their induction in vivo by vaccination remains challenging. Considering that the ability of an epitope to elicit effective humoral immunity depends on its exposure on the virion, we have used a reverse genetics approach to select variants from an HIV-1 AC10_29 randomly mutated envelope library that showed increased affinity for a selected bNAb (4E10 bNAb targeting the HIV-1 MPER region). Isolated envelope sequences were analyzed by deep-sequencing showing a small number of dominant changes, including the loss of four potential N-linked glycosylation sites and disruption of the V1/V2 loop. Accordingly, the dominant variant (LR1-C1), showed not only increased affinity for MPER bNAbs 4E10 and 2F5, but also higher affinity for an additional antibody targeting the V3 loop (447-52D) that could be a consequence of an open conformation tier 1-like Env. Furthermore, the amino acids specific for the selected variant are associated with an increased sensitivity for 4E10 and 2F5 antibodies. In vivo studies showed that sera from mice immunized with LR1-C1 viruses possessed an improved neutralizing activity compared to the wild-type AC10_29 env. While Virus Like Particles (VLPs) carrying this envelope were unable to induce detectable neutralizing activity in immunized rabbits, one animal showed antibody response to the 4E10-proximal region. Our data establish a novel approach that has the potential to yield HIV envelope immunogen sequences that direct antibody responses to specific envelope regions.
Stem Cell Markers SOX-2 and OCT-4 Enable to Resolve the Diagnostic Dilemma between Ameloblastic Carcinoma and Aggressive Solid Multicystic Ameloblastoma

Background: Ameloblastic carcinoma (ACA) is a malignant neoplasm with overlapping histopathological features of benign aggressive solid multicystic ameloblastoma (SMA). This often leads to misdiagnosis with direct implication on the management protocol. The need of the hour is to adopt reliable tissue biomarkers to differentiate these lesions accurately that will help to implement an appropriate treatment modality. Few studies to differentiate ACA and SMA in literature with a limitation of a single marker and lack of availability of cases have prompted us to undertake this study. Thereby, this study is aimed at resolving the diagnostic dilemma in differentiating ACA and aggressive SMA using SOX-2, OCT-4 and CD44. Materials and Methods: Tissue samples involved 40 archival cases of histopathologically confirmed cases of ACA (n = 20) and SMA (n = 20). The sections were subjected to immunohistochemical staining using antibodies to SOX-2, OCT-4 and CD44. Nuclear staining for SOX-2 and OCT-4 and membranous reactivity for CD44 was considered positive. Results: The expression of SOX-2 and OCT-4 in ACA was statistically significant when compared to SMA (P < 0.001). CD44 showed an insignificant statistical value of <0.077 in differentiating ACA and SMA. SOX-2 and OCT-4 expression in ACA showed a significant correlation coefficient of 0.616 at P < 0.004. Conclusions: SOX-2 and OCT-4 could serve as independent novel markers in resolving the diagnostic dilemma between ACA and aggressive SMA.
The pleasures of children's literature

I. INTRODUCTION. 1. How to Read this Book. Studying Literature: Some Basic Assumptions Opinion and Dialogue. Writing About What You Read. 2. How to Read Children's Literature. Seeing Beyond an Adult Perspective. The Implied Reader. Children's Literature and Adult Literature: Differences and Similarities. The Pleasures of Literature. 3. Teaching Children Literature. Focusing on Literary Strategies. Can Pleasure Be Taught? What Not to Teach. What to Teach. Teaching Literary Strategies. 4. Strategies for Reading a Literary Text. Schemata and Reading. Gaps in Texts. Filling in the Gaps: Strategies for Building Consistency. II. CULTURE, IDEOLOGY, AND CHILDREN'S LITERATURE. 5. Common Assumptions About Childhood. Children in Ideology. Childhood in History. Childhood Now. Some Common Assumptions. Assumptions as Ideology. Why the Assumptions Might Be True. Why the Assumptions Can't Be the Whole Truth. But They're Sometimes True Anyway. The Assumptions and Power: Why Do We Have Them? Beyond the Child as Other. But Are Children Different After All? Childhood Reading and Censorship. 6. Children's Literature in the Marketplace. Children's Choices: The Freedom to Be Unique? The Field of Children's Literature. The Producers of Children's Literature. Who Sells Books for Children? Who Buys Books for Children? Fewer Books. The Strange Case of Harry Potter. 7. The World of Children's Culture. Unavoidable Teaching. Nonfiction: Is It Nonfictional? The World of Children's Toys and Games. The World of Children's TV. The World of Children's Movies Toys, TV, Movies: A Repertoire For Life and Literature. Freeing Children from Culture? 8. Literature and Ideology. History and Culture. Reading Against a Text. Surfacing Political Assumptions. Surfacing Assumptions About Gender. Multiculturalism: Surfacing Assumptions About Race and Ethnicity. Surfacing Assumptions About Individuality. III. CHILDREN'S LITERATURE AND THE LITERARY REPERTOIRE. 9. Children's Literature as Repertoire. Intertextuality. Texts as Contexts for Each Other. Children's Literature as a Genre. Characteristics of the Genre. The Genre Today. Genre and Formula. 10. The Repertoire of Theory. Reading in the Context of Theory. Reader-Response Theories. Psychoanalytic Theories. Archetypal Theories. Structuralist Theories. Ideological Theories. Cultural Studies. Values and Canons. IV. KINDS OF CHILDREN'S LITERATURE. 11. Poetry. Poetry for Children? The Pleasures of Sound and Image. Experiencing Poetry. Children's Poetry: The Making of Anthologies. Why Many People Don't Like Poetry-And What to Do About It. 12. Picture Books. The Visual Imagination and Pictorial Comprehension. The Pleasures of Picture Books. How Pictures Provide Information About Stories. Storytelling in Words and Pictures. Picture Books as Puzzles. Picture Books for Older Children. 13. Fairy Tales and Myths. A Common Repertoire. The History of Fairy Tales. Oral Tales from Written Versions: Variant Versions. Cultural Values. Which Versions Should Children Read? Characteristics of Fairy Tales. Literary Fairy Tales. Myths. Afterword. Continuing The Dialogue.
Convoluted nasal passages function as efficient heat exchangers in ankylosaurs (Dinosauria: Ornithischia: Thyreophora)

Convoluted nasal passages are an enigmatic hallmark of Ankylosauria. Previous research suggested that these convoluted nasal passages functioned as heat exchangers analogous to the respiratory turbinates of mammals and birds. We tested this hypothesis by performing a computational fluid dynamic analysis on the nasal passages of two ankylosaurs: Panoplosaurus mirus and Euoplocephalus tutus. Our models predicted that Panoplosaurus and Euoplocephalus would have required 833 and 1568 thermal calories, respectively, to warm a single breath of air by 20°C. Heat recovery during exhalation resulted in energy savings of 65% for Panoplosaurus and 84% for Euoplocephalus. Our results fell well within the range of values for heat and water savings observed in extant terrestrial amniotes. We further tested alternate airway reconstructions that removed nasal passage convolutions or reduced nasal vestibule length. Our results revealed that the extensive elaboration observed in the nasal vestibules of ankylosaurs was a viable alternative to respiratory turbinates with regards to air conditioning. Of the two dinosaurs tested, Euoplocephalus repeatedly exhibited a more efficient nasal passage than Panoplosaurus. We suggest that the higher heat loads associated with the larger body mass of Euoplocephalus necessitated these more efficient nasal passages. Our findings further indicate that the evolution of complicated airways in dinosaurs may have been driven by the thermal requirements of maintaining cerebral thermal homeostasis.