Miracle-dz/UniFAR-FTUs huggingface dataset:
Developmental Regulation of Eed Complex Composition Governs a Switch in Global Histone Modification in Brain*

Originally discovered as epigenetic regulators of developmental gene expression, the Polycomb (PcG) and trithorax (trxG) group of proteins form distinct nuclear complexes governing post-translational modification of histone tails. This study identified a novel, developmentally regulated interface between Eed and Mll, pivotal constituents of PcG and trxG pathways, respectively, in mouse brain. Although the PcG proteins Eed and EzH2 (Enhancer of Zeste protein-2) engaged in a common complex during neurodevelopment, Eed associated with the trxG protein Mll upon brain maturation. Comprehensive analysis of multiple histone modifications revealed differential substrate specificity of the novel Eed-Mll complex in adult brain compared with the developmental Eed-EzH2 complex. Newborn brain from eed heterozygotes and eed;Mll double heterozygotes exhibited decreased trimethylation at lysine 27 of histone H3, as well as hyperacetylation of histone H4. In contrast, adult hippocampus from Mll heterozygotes was remarkable for decreased acetylation of histone H4, which restored to wild-type levels in eed;Mll double heterozygotes. A physiological role for the Eed-Mll complex in adult brain was evident from complementary defects in synaptic plasticity in eed and Mll mutant hippocampi. These results support the notion that developmental regulation of complex composition bestows the predominant Eed complex with the chromatin remodeling activity conducive for gene regulation during neurodevelopment and adult brain function. Thus, this study suggests dynamic regulation of chromatin complex composition as a molecular mechanism to co-opt constituents of developmental pathways into the regulation of neuronal memory formation in adult brain.
On the Influence of Text Content on Pass-Phrase Strength for Short-Duration Text-Dependent Automatic Speaker Authentication

In the context of automatic speaker verification it is well known that different speech units offer different levels of speaker discrimination. For short-duration, text-dependent automatic speaker recognition, a user’s pass-phrase bears influence on how reliably they can be recognized; just as is the case with text passwords, some spoken pass-phrases are more secure than others. This paper investigates the influence of text or phone content on recognition performance. This work is performed using the shortest duration subset of the standard RSR2015 database. With a thorough statistical analysis, the work shows how significant reductions in error rates can be achieved by preventing the use of weak passwords and that improvements in performance are consistent across disjoint speaker subsets. The ultimate goal of this work is to develop an automated means of enforcing the use of stronger or more discriminant spoken pass-phrases.
Graph Colouring is Hard for Algorithms Based on Hilbert's Nullstellensatz and Gröbner Bases

We consider the graph k-colouring problem encoded as a set of polynomial equations in the standard way. We prove that there are bounded-degree graphs that do not have legal k-colourings but for which the polynomial calculus proof system defined in [Clegg et al. 1996, Alekhnovich et al. 2002] requires linear degree, and hence exponential size, to establish this fact. This implies a linear degree lower bound for any algorithms based on Grobner bases solving graph k-colouring using this encoding. The same bound applies also for the algorithm studied in a sequence of papers [De Loera et al. 2008, 2009, 2011, 2015] based on Hilbert's Nullstellensatz proofs for a slightly different encoding, thus resolving an open problem mentioned, e.g., in [De Loera et al. 2009] and [Li et al. 2016]. We obtain our results by combining the polynomial calculus degree lower bound for functional pigeonhole principle (FPHP) formulas over bounded-degree bipartite graphs in [Miksa and Nordstrom 2015] with a reduction from FPHP to k-colouring derivable by polynomial calculus in constant degree.
Influence of feeding a fish oil-containing diet to young, lean, adult dogs: effects on lipid metabolites, postprandial glycaemia and body weight

The aim of this study was to determine the effect of feeding a fish oil (FO)-containing diet on lipid and protein metabolism, postprandial glycaemia and body weight in young, lean, adult dogs. Eight female Beagles were randomly assigned to one of two isonitrogenous and isoenergetic diets, Control or FO, in a crossover design. At the beginning of the experiment and at 30 and 60 d, a baseline blood sample was collected and the dogs then were fed their daily ration. Nitrogen balance began at 07:00 h on day 63 of each experimental period and ended at 07:00 h on day 69. On day 66 of each period, a single dose (7.5 mg/kg) of 15N-glycine was administered orally to each dog via gelatin capsule. Postprandial glycaemia did not differ between treatments or among sampling days within treatment. Cholesterol concentration was increased (p < 0.05) on the Control treatment throughout the experiment when compared to values of day 0. Dogs fed the FO treatment had higher plasma triglyceride and ghrelin concentrations than those fed the Control treatment. Body weight and food intake did not differ between dietary treatments. Faecal excretion was increased (p < 0.05) in the FO treatment. Dry matter digestibility was decreased (p < 0.05) and fat digestibility tended (p < 0.10) to decrease in the FO treatment. Overall, feeding a FO-containing diet showed a protective effect against the rise of plasma cholesterol and it increased plasma ghrelin concentration. However, FO supplementation did not appear to affect protein metabolism or postprandial glycaemia in adult lean dogs.
THE EFFECTS OF ALCOHOL-RELATED VISUAL STIMULI ON INHIBITORY CONTROL AND ATTENTIONAL BIAS: TESTING THE ROLES OF CLASSICAL CONDITIONING AND SEMANTIC PRIMING

OF THESIS THE EFFECTS OF ALCOHOL-RELATED VISUAL STIMULI ON INHIBITORY CONTROL AND ATTENTIONAL BIAS: TESTING THE ROLES OF CLASSICAL CONDITIONING AND SEMANTIC PRIMING Alcohol research has shown that alcohol-related stimuli can disrupt behavioral control and attract more attention in alcohol drinkers. Stimuli typically used in tasks assessing these mechanisms are likely representative of an individual's history. Responses to visual stimuli that no longer closely resemble an individual's history may help shed light on whether these behaviors are due to classical conditioning or processes such as semantic priming. Hypotheses were tested using typical visual stimuli and modified, abstract versions in these tasks. 41 participants were exposed to these stimuli types while using a visual dot probe task. The difference in degree of attentional bias between real and modified stimuli was determined using gaze time. Individuals participated in two versions of the attentional bias-behavioral activation (ABBA) task. Proportion of inhibitory failure differences between versions was examined for the effects of stimuli modification on behavioral control. Results demonstrated that the sample did not exhibit an attentional bias to alcohol. Visual probe results yielded no differences between real and modified stimuli on attentional bias. ABBA performance indicated no differences as a result of image abstraction or stimuli type. Reasons for these findings and comparisons to similar research inquiries using the tasks the current thesis utilized were explored.
Lycopene: a biologically important carotenoid for humans?

Lycopene is a carotenoid present in human blood (approximately 0.5 micromol/liter plasma), and the tissue levels vary from 1 nmol/g wet wt in adipose tissue to up to 20 nmol/g wet wt in adrenals and testes. Its biological activities include antioxidant activity (singlet oxygen quenching and peroxyl radical scavenging), induction of cell-cell communication, and growth control, but no provitamin A activity. Epidemiological studies suggest protective effects of lycopene on some types of cancer, e.g., prostate cancer. In vitro and in vivo studies on growth of tumor cells support this conclusion. The major sources of lycopene for the human are tomatoes and tomato products, and bioavailability from different food items varies considerably. Lycopene oxidation products have recently been identified in human serum. Suggested health effects of lycopene require further investigation.
Clinicopathological significance of B-cell-specific Moloney murine leukemia virus insertion site 1 expression in gastric carcinoma and its precancerous lesion.

AIM To explore the relation between B-cell-specific Moloney murine leukemia virus insertion site 1 (Bmi-1) expression and the clinicopathological features of gastric carcinoma (GC). METHODS Immunohistochemistry was used to detect the expression of Bmi-1 and ki-67. Double-labeling staining was used to display the distribution of Bcl-2(+)/ki-67(-) cells in 162 cases of GC and its matched normal mucosa and precancerous lesion. RESULTS The positive rate of Bmi-1 expression in GC (52.5%) was significantly higher than that in normal gastric mucosa (21.6%, chi(2) = 33.088, P < 0.05). The Bmi-1 expression in GC was closely related with the Lauren's and Borrmann's classification and clinical stage (chi(2) = 4.400, 6.122 and 11.190, respectively, P < 0.05). The expression of ki-67 was related to the Borrmann's classification (chi(2) = 13.380, P < 0.05). Bcl-2 expression was correlated with the Lauren's classification (chi(2) = 4.725, P < 0.05), and the Bmi-1 expression both in GC (r(k) = 0.157, P < 0.05) and in intestinal metaplasia (r(k) = 0.270, P < 0.05). CONCLUSION Abnormal Bmi-1 expression in GC may be involved in cell proliferation, apoptosis and cancerization. This marker can objectively indicate the clinicopathological characteristics of GC.
ASEAN integration: Malaysian business undergraduates’readiness and perspectives on priority issues

This study examined the perception of business undergraduates in a Malaysian university on their readiness to exploit regional opportunities following the establishment of the ASEAN Economic Community (AEC) by end 2015 as well as their perspectives on priory issues for ASEAN co-operation.It is found that while the majority of business undergraduates support the AEC and the freer flow of skilled professionals within the region, many students do not feel confident in their ability to compete with other ASEAN graduates. The business undergraduates’ readiness to compete with other ASEAN undergraduates were found to be positively correlated with their self-perception of their soft skill abilities. The students rated their ASEAN inter-cultural skills, comprising understanding of ASEAN languages, cultures and business etiquettes as their weakest soft skills.The study also revealed the “push and pull factors” of intra-ASEAN skilled labour mobility as perceived by business undergraduates. The findings of this research has important implications.In order to better equip graduates for a borderless job market in ASEAN as envisaged under the AEC, ASEAN universities should intensify efforts to develop multicultural skills among young graduates.Existing programs to develop soft skills may have overlooked the importance of multicultural skills, particularly intercultural ASEAN skills.
Vibration analysis of fluid-conveying double-walled carbon nanotubes based on nonlocal elastic theory

This paper presents an analytical solution to a coupled vibration problem of fluid-conveying double-walled carbon nanotubes (DWCNTs) and analyzes the influences of nonlocal effect, aspect ratio and van der Waals interaction on the fundamental frequency. According to the analysis, the results show that the vibration frequencies of the first three modes of DWCNTs are lower than those of single-walled carbon nanotubes (SWCNTs). The trend is more obvious when the flow velocity is high. It can also be found that the velocity of vibration-induced flutter instability for DWCNTs is lower than that of SWCNTs. In addition, the frequency of mode 1 of DWCNTs decreases with increasing nonlocal parameter. However, the frequency increases as the aspect ratio and the van der Waals interaction increased, especially at higher flow velocities.
Linking the DISABKIDS modules for health-related quality of life assessment with the International Classification of Functioning, Disability and Health (ICF)

Purpose. The aim of this study was to examine the relationship between all established DISABKIDS modules and the International Classification of Functioning, Health and Disability (ICF). The DISABKIDS questionnaires were developed as a tool set of both condition-generic and condition-specific modules for assessing the health-related quality of life of children and adolescents with medical conditions. Methods. All DISABKIDS modules were linked to the ICF by two trained health experts using a set of previously published linking rules. Results. We have identified 210 meaningful concepts from a total of 144 items included in all questionnaires. Concepts represented by the items in the nine different questionnaires of the DISABKIDS measurement tool set were linked to 49 different categories of the ICF: 18 categories of the component ‘Body Functions’, 21 categories of the component ‘Activities and Participation’ and 10 categories of the component ‘Environmental Factors’. Conclusions. This article strongly emphasises the usefulness of the ICF as a framework and provides interesting insights into differences and similarities between the generic and the condition-specific DISABKIDS modules.
GOVERNMENT DEBT MANAGEMENT AT THE ZERO LOWER BOUND

This paper re-examines government debt management policy in light of the U.S. experience with extraordinary fiscal and monetary policies since 2008. We first document that the Treasury’s decision to lengthen the average maturity of the debt has partially offset the Federal Reserve’s attempts to reduce the supply of long-term bonds held by private investors through its policy of quantitative easing. We then examine the appropriate debt management policy for the consolidated government. We argue that traditional considerations favoring longer-term debt may be overstated, and suggest that there are several advantages to issuing greater quantities of short-term debt. Under current institutional arrangements, neither the Federal Reserve nor the Treasury is caused to view debt management policy on the basis of the overall national interest. We suggest revised institutional arrangements to promote greater cooperation between the Treasury and the Federal Reserve in setting debt management policy. This is particularly important when conventional monetary policy becomes constrained by the zero lower bound, leaving debt management as one of the few policy levers to support aggregate demand.
Thymidine Phosphorylase Expression in Gallbladder Adenocarcinomas

The expression of thymidine phosphorylase (TP), a potent chemotactic factor for enothelial cells, was studied in 60 adenocarcinomas of the gallbladder, by use of imunohistochemical techniques. Results on patterns of TP expression were correlated with angiogenesis (anti-CD31), histopathological variables, and patient survival. TP was frequently expressed in tumor cells, stromal cells, tumor-associated macrophages, and lymphocytes of gallbladder adenocarcinomas. The expression was mixed nuclear/cytoplasmic. However, only nuclear TP (TPnuc) expression by tumor cells was correlated with increased angiogenic activity. High angiogenesis, assessed as microvessel density (MVD), was the most significant prognostic factor. The subgroup of patients with TPnuc and medium/high MVD had the worst prognosis as evaluated by the survival curves. Furthermore, CD31+ lymphocytes, frequently seen in carciomas with high-fibroblastic TP reactivity, were connected with an improved surival. It is concluded that angiogenesis, as verified by multivariate analysis, is the most important prognostic factor in gallbladder carcinomas. In these tumors, high histologic grade and low CD31+ lymphocytic infiltration are also independent preictors of poor prognosis. TP is associated with an aggressive phenotype apparently because of its anglogenic activity. Therapeutic strategies targeting TP may be of value in patients overexpressing this enzyme.
Determinants of Shopper Behaviour in E-tailing: An Empirical Analysis

Consumers’ decision-making process has been changed with the introduction of the Internet as on alternative channel for shopping. E-tailing is an emergent area of nascent organized retailing in India. The purpose of this paper is to explore the determinants of shopper behaviour such as convenience, customer service, trust, web store environment, and web shopping enjoyment and to examine the influence of these factors towards willingness to buy and patronage of online retail stores. The study is purely based on primary data collected from a sample of 135 respondents by using simple random sampling technique from five leading software companies in Hyderabad. Necessary secondary data were used to reinforce the model. A structured non-disguised questionnaire was administered and responses were measured on the seven-point Likert scale. Statistical tools like mean, standard deviation, multiple correlations, multiple regressions, student t-test, and ANOVA were used to find out the strength of relationship and degree of association among the variables entered into the model. The results reveal that convenience, web store environment, online shopping enjoyment, and customer service have significant impact on the willingness to buy from online retail stores rather than perceived trust. Except trust and customer service, all other variables are significant with patronage of online retail stores. As not much work in India has been done in this context, the paper seeks to provide fruitful insights into the factors determining the prospects of e-tailing that can benefit academicians as well as marketers.
The (Self-) Funding of Intangibles

In response to technological change, U.S. corporations have been investing more in intangible capital. This transformation is empirically associated with lower leverage and greater cash holdings, and commonly explained as a precautionary response to reduced debt capacity. We model how firms' payout and cash holding policies are affected by this shift. Our insight is that the creation of intangibles is largely achieved by human capital investment and requires lower upfront outlays. Firms can self-finance the retention of human capital by granting deferred equity compensation. Interestingly, retaining cash and repurchasing shares enhances the value of unvested equity, thereby facilitating retention and reducing equity dilution. Our empirical evidence confirms that firms with higher intangible investment have lower upfront investment needs. They make similar payouts as tangible investment firms, suggesting they are not on average more financially constrained. They also tend to grant more deferred equity and prioritize repurchases over dividends in particular when their stock volatility is high, in line with our model's predictions.
Transport capacity for networks of interfering multiple-access channels

We analyze the distance-weighted rate achievable in wireless networks that utilize multiple antennas and multi-user links. We give the transport capacity of vector multiple-access channels, and use this network topology at the physical layer of an ad-hoc network to obtain achievable distance-weighted rate regions for a multiple-antenna wireless network. These regions are obtained by considering interfering multiple-access in all possible link configurations. We give an analytic upper bound on the capacity and show that in networks with an asymptotically large number of nodes the throughput grows with the number of antennas, and depends on the expected path loss between nodes. Numerical examples agree with the analysis and show the benefit of interfering multiple-access over interfering point-to-point links for a uniform per-node power constraint.
Alteration of active Na-K transport on protein kinase C activation in cultured ciliary epithelium.

PURPOSE Experiments were conducted to test whether protein kinase C activation causes changes in active sodium-potassium transport in an established SV-40 transformed line (ODM2) of cultured human nonpigmented ciliary epithelial cells. METHODS Rubidium-86 (86Rb) uptake was measured and the data used to determine the rate of potassium entry into the cells. RESULTS Protein kinase C activator, phorbol dibutyrate (PDBu), caused a stimulation of ouabain-sensitive 86Rb uptake. Inhibition of protein kinase C by 1-(5-isoquinolinylsulfonyl) 2-methylpiperazine (H-7), or down-regulation of protein kinase C activation by prolonged exposure of PDBu, decreased the PDBu response. These results suggest that protein kinase C plays a role in Na-K pump activation. The Na/H+ exchanger inhibitor, amiloride, also reduced the stimulation of the ouabain-sensitive 86Rb uptake by PDBu. 86Rb efflux was not altered by protein kinase C activation. At the same time that PDBu increased the ouabain-sensitive 86Rb uptake, it also decreased the ouabain-insensitive 86Rb uptake. The ouabain-insensitive 86Rb uptake component could be inhibited by bumetanide, suggesting that protein kinase C activation decreases the activity of a Na/K/2Cl cotransporter. CONCLUSIONS These findings suggest that activation of protein kinase C may stimulate Na,K-ATPase activity mainly by a mechanism involving increased Na+ influx mediated by the Na+/H+ exchanger.
The ac stark shift and space-borne rubidium atomic clocks

Due to its small size, low weight, and low power consumption, the Rb atomic frequency standard (RAFS) is routinely the first choice for atomic timekeeping in space. Consequently, though the device has very good frequency stability (rivaling passive hydrogen masers), there is interest in uncovering the fundamental processes limiting its long-term performance, with the goal of improving the device for future space systems and missions. The ac Stark shift (i.e., light shift) is one of the more likely processes limiting the RAFS' long-term timekeeping ability, yet its manifestation in the RAFS remains poorly understood. In part, this comes from the fact that light-shift induced frequency fluctuations must be quantified in terms of the RAFS' light-shift coefficient and the output variations in the RAFS' rf-discharge lamp, which is a nonlinear inductively-couple plasma (ICP). Here, we analyze the light-shift effect for a family of 10 on-orbit Block-IIR GPS RAFS, examining decade-long records of their on-orbit f.