Miracle-dz/UniFAR-FTUs huggingface dataset:
Long-chain n-3 PUFA against breast and prostate cancer: Which are the appropriate doses for intervention studies in animals and humans?

abstract The potential antineoplastic effect of the long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) remains a highly controversial issue. Numerous animal studies have supported the anticancer role of these dietary fatty acids, whereas conflicting results have been obtained in population studies, and only a few intervention human trials have been so far performed. In view of the possibility that the anticancer effects may be maximally observed within a defined range of EPA and DHA doses, herein we critically review the results and doses used in both animal studies and human clinical trials focusing on the possible n-3 PUFA protective effects against breast and prostate cancer. Our main aim is to identify the EPA and/or DHA ranges of doses needed to obtain clear anticancer effects. This may be of great help in designing future animal studies, and also in understanding the most appropriate dose for further human intervention studies. Moreover, since the healthy effects of these fatty acids have been strictly related to their increased incorporation in plasma and tissue lipids, we also examine and discuss the incorporation changes following the administration of the effective anticancer EPA and/or DHA doses in animals and humans.
Vocal responses to frequency modulated composite sinewaves via auditory and vibrotactile pathways

Feedback control mechanisms for speaking have been examined using the transformed auditory feedback (TAF) technique. Previous studies have shown that speakers demonstrate fundamental frequency (F0) changes when they monitor their voice with artificial alterations of F0. However, those studies underestimate the role of vibrotactile information involved in feedback F0 control. This pilot study aims at exploring whether and how vibrotactile information from the larynx influences vowel F0. Participants in our experiment were asked to sustain vowel with their F0 adjusted to composite sinewave stimuli, which were given via auditory and vibrotactile channels using a headset on the ears or a bone-conduction transducer on the larynx. Results revealed the greater compensatory responses to combined vibrotactile-auditory stimuli than to the responses to auditory-only stimuli. The effect of vibrotactile stimuli on feedback F0 adjustment was also observed with the shorter latency of the responses.
Drivers and fitness consequences of dispersive migration in a pelagic seabird

Lay Summary Sex segregation, competition and differences in individual quality may drive dispersive migration in birds and affect their fitness. Atlantic puffins tracked for up to 6 years followed remarkably different migration routes, but individuals followed the same route every year. Although random dispersion and sex segregation could not explain the patterns observed, birds visiting the Mediterranean Sea foraged more and had a higher breeding success than birds remaining locally or visiting the Atlantic Ocean.
Characterization of Pulsed-Laser-Deposited Aln Films as a Gate Dielectric in Aln-Si Mis Structures

MIS structures with AlN films deposited on p-Si substrates by pulsed laser deposition (PLD) were analyzed with respect to their capacitance-voltage and conductance-voltage characteristics, measured at different frequencies and temperatures of 77 and 300 K. The current-voltage characteristics were independent on temperature. It was shown that inter-trap tunneling could adequately account for the observed tunneling currents in these MIS structures
Replication of early and recent Zika virus isolates throughout mouse brain development

Significance Zika virus (ZIKV) infection has been associated with multiple pathologies of the central nervous system (CNS) including microcephaly, Guillain-Barré syndrome, lissencephaly, the loss of white and gray matter volume and acute myelitis. Using organotypic brain slice cultures, we determined that ZIKV replicates across different embryonic developmental stages, and viral infection can disrupt proper brain development leading to congenital CNS complications. These data illustrate that all lineages of ZIKV tested are neurotropic, and that infection may disrupt neuronal migration during brain development. The results expand our understanding of neuropathologies associated with congenital Zika virus syndrome. Fetal infection with Zika virus (ZIKV) can lead to congenital Zika virus syndrome (cZVS), which includes cortical malformations and microcephaly. The aspects of cortical development that are affected during virus infection are unknown. Using organotypic brain slice cultures generated from embryonic mice of various ages, sites of ZIKV replication including the neocortical proliferative zone and radial columns, as well as the developing midbrain, were identified. The infected radial units are surrounded by uninfected cells undergoing apoptosis, suggesting that programmed cell death may limit viral dissemination in the brain and may constrain virus-associated injury. Therefore, a critical aspect of ZIKV-induced neuropathology may be defined by death of uninfected cells. All ZIKV isolates assayed replicated efficiently in early and midgestation cultures, and two isolates examined replicated in late-gestation tissue. Alteration of neocortical cytoarchitecture, such as disruption of the highly elongated basal processes of the radial glial progenitor cells and impairment of postmitotic neuronal migration, were also observed. These data suggest that all lineages of ZIKV tested are neurotropic, and that ZIKV infection interferes with multiple aspects of neurodevelopment that contribute to the complexity of cZVS.
Exposure–Response Analysis of Alvocidib (Flavopiridol) Treatment by Bolus or Hybrid Administration in Newly Diagnosed or Relapsed/Refractory Acute Leukemia Patients

Purpose: To elucidate any differences in the exposure–response of alvocidib (flavopiridol) given by 1-hour bolus or a hybrid schedule (30-minute bolus followed by a 4-hour infusion) using a flavopiridol/cytosine arabinoside/mitoxantrone sequential protocol (FLAM) in patients with acute leukemia. The hybrid schedule was devised to be pharmacologically superior in chronic leukemia based on unbound exposure. Experimental Design: Data from 129 patients in three FLAM studies were used for pharmacokinetic/pharmacodynamic modeling. Newly diagnosed (62%) or relapsed/refractory (38%) patients were treated by bolus (43%) or hybrid schedule (57%). Total and unbound flavopiridol concentrations were fit using nonlinear mixed-effect population pharmacokinetic methodologies. Exposure–response relationships using unbound flavopiridol AUC were explored using recursive partitioning. Results: Flavopiridol pharmacokinetic parameters were estimated using a two-compartment model. No pharmacokinetic covariates were identified. Flavopiridol fraction unbound was 10.9% and not different between schedules. Partitioning found no association between dosing schedule and clinical response. Clinical response was associated with AUC ≥ 780 h*ng/mL for newly diagnosed patients and AUC ≥ 1,690 h*ng/mL for relapsed/refractory patients. Higher exposures were not associated with increases in severe adverse events (≥ grade 3). Conclusions: Pharmacokinetic modeling showed no difference in flavopiridol plasma protein binding for bolus versus hybrid dosing. Further trials in newly diagnosed patients with acute leukemia should utilize the bolus FLAM regimen at the MTD of 50 mg/m2/day. Trials in relapsed/refractory patients should use the hybrid dosing schedule at the MTD (30/60 mg/m2/day) to achieve the higher exposures required for maximal efficacy in this population. Clin Cancer Res; 23(14); 3592–600. ©2017 AACR.
A novel CuxSiyO resistive memory in logic technology with excellent data retention and resistance distribution for embedded applications

A new Cu<inf>x</inf>Si<inf>y</inf>O resistive memory, which is different from Cu-doped SiO<inf>2</inf> or CuxO binary oxide, is integrated successfully in standard logic technology for the first time. Key breakthrough is that data retention (10 years@ 150°C), resistance distribution (with 50x window@125 °C ) and disturbance immunity significantly improved with integration simplicity advantage, as demonstrated on a 1Mb test chip. The activation energy of Cu vacancy migration in Cu<inf>x</inf>Si<inf>y</inf>O increases by 5 times than that in Cu<inf>x</inf>O, giving rise to the great performance improvement. The solution is promising for both high density and low cost embedded nonvolatile memory (NVM) applications.
Immunomodulatory effect of various anti-parasitics: a review

This paper reviews the immunomodulatory effects (immunosuppression or immunoactivation) of various anthelmintics including levamisole, fenvalerate, dieldrin, carbofuran, aminocarb, thiabendazole, fenbendazole, oxfendazole and ivermectin. The induced modulation of immune function may occur via direct and/or indirect mechanisms. The immunomodulatory effects of these anti-parasitics have been studied in a variety of bacterial (e.g. brucellosis, salmonellosis, paratuberculosis, mastitis), viral (e.g. infectious bovine rhinotracheitis, Herpes, foot and mouth disease), parasitic (e.g. onchocerciasis, coccidiosis, ascariasis, schistosomiasis) and neoplastic diseases. Some antiparasitics have also been used to boost immunity in a number of human diseases including leprosy, Hodgkin's disease, rheumatoid arthritis, and in adjuvanted therapy of colorectal cancer. The ability to stimulate the immune response of animals offers a new means of disease intervention. Future research on immunomodulatory effects of anti-parasitics, for humans and domestic farm animals, will provide additional methods of treating immunosuppressed subjects. The immunopotentiating or immunosuppressing activity of anti-parasitics will dictate whether co-administration of vaccines and anthelmintics or administration of vaccines during the window of immunoactivation is justified or not.
Possible augmentation of antidepressant response by buspirone.

In open trials, seven of eight antidepressant nonresponders reported partial or full antidepressant response after the addition of buspirone 10 mg t.i. d. An additional eight of nine patients who suffered winter relapses of depression while receiving previously effective antidepressant regimens showed remission of depressive symptoms after the addition of buspirone 10 mg t.i. d. Improvement after the addition of buspirone was maintained for at least 3 months, and side effects were minimal in most patients. These results suggest that low doses of buspirone may be useful in augmenting antidepressant response.
Inhibition of Src Family Kinases with Dasatinib Blocks Migration and Invasion of Human Melanoma Cells

Src family kinases (SFK) are involved in regulating a multitude of biological processes, including cell adhesion, migration, proliferation, and survival, depending on the cellular context. Therefore, although SFKs are currently being investigated as potential targets for treatment strategies in various cancers, the biological responses to inhibition of SFK signaling in any given tumor type are not predictable. Dasatinib (BMS-354825) is a dual Src/Abl kinase inhibitor with potent antiproliferative activity against hematologic malignancies harboring activated BCR-ABL. In this study, we show that dasatinib blocks migration and invasion of human melanoma cells without affecting proliferation and survival. Moreover, dasatinib completely inhibits SFK kinase activity at low nanomolar concentrations in all eight human melanoma cell lines investigated. In addition, two known downstream targets of SFKs, focal adhesion kinase and Crk-associated substrate (p130CAS), are inhibited with similar concentrations and kinetics. Consistent with inhibition of these signaling pathways and invasion, dasatinib down-regulates expression of matrix metalloproteinase-9. We also provide evidence that dasatinib directly inhibits kinase activity of the EphA2 receptor tyrosine kinase, which is overexpressed and/or overactive in many solid tumors, including melanoma. Thus, SFKs and downstream signaling are implicated as having key roles in migration and invasion of melanoma cells. (Mol Cancer Res 2008;6(11):1766–74)
[A history of food].

Have spare times? Read a history of food writer by Why? A best seller publication in the world with excellent worth as well as content is combined with fascinating words. Where? Simply here, in this website you could read online. Want download? Naturally offered, download them likewise here. Available data are as word, ppt, txt, kindle, pdf, rar, and also zip. Need a great electronic book? a history of food by , the best one! Wan na get it? Locate this exceptional e-book by below currently. Download and install or review online is available. Why we are the best website for downloading this a history of food Certainly, you can pick the book in various file kinds as well as media. Try to find ppt, txt, pdf, word, rar, zip, and kindle? Why not? Obtain them below, now! Whatever our proffesion, a history of food can be excellent resource for reading. Discover the existing reports of word, txt, kindle, ppt, zip, pdf, and rar in this site. You can completely read online or download this book by here. Currently, never miss it. GO TO THE TECHNICAL WRITING FOR AN EXPANDED TYPE OF THIS A HISTORY OF FOOD, ALONG WITH A CORRECTLY FORMATTED VERSION OF THE INSTANCE MANUAL PAGE ABOVE.
Acute and chronic effects of aquatic treadmill training on land treadmill running kinematics: A cross-over and single-subject design approach

ABSTRACT The aim of this study was to determine if selected kinematic measures (foot strike index [SI], knee contact angle and overstride angle) were different between aquatic treadmill (ATM) and land treadmill (LTM) running, and to determine if these measures were altered during LTM running as a result of 6 weeks of ATM training. Acute effects were tested using 15 competitive distance runners who completed 1 session of running on each treadmill type at 5 different running speeds. Subsequently, three recreational runners completed 6 weeks of ATM training following a single-subject baseline, intervention and withdrawal experiment. Kinematic measures were quantified from digitisation of video. Regardless of speed, SI values during ATM running (61.3 ± 17%) were significantly greater (P = 0.002) than LTM running (42.7 ± 23%). Training on the ATM did not change (pre/post) the SI (26 ± 3.2/27 ± 3.1), knee contact angle (165 ± 0.3/164 ± 0.8) or overstride angle (89 ± 0.4/89 ± 0.1) during LTM running. Although SI values were different between acute ATM and LTM running, 6 weeks of ATM training did not appear to alter LTM running kinematics as evidenced by no change in kinematic values from baseline to post intervention assessments.
Aprendizagem espaço-temporal e efeitos das condições luminosas no aprendizado do peixe paulistinha

Para processar a informacao ambiental e perceber o tempo, os individuos utilizam-se de pistas ambientais, como luz e temperatura, que servem como guias para o relogio interno. O mecanismo temporizador endogeno e chamado relogio circadiano, o qual comanda uma grande variedade de ritmos diarios bioquimicos, fisiologicos e comportamentais presentes nos organismos. Com isso, os animais podem antecipar eventos espaco-temporalmente distribuidos e usar essa informacao para organizar as atividades diarias, o que e uma vantagem adaptativa para os individuos, ja que muitos fatores ambientais apresentam variacao circadiana. Aprendizagem espaco-temporal (do ingles: "time-place learning’’-TPL) e a habilidade de associar lugares com importantes eventos biologicos em diferentes horas do dia. Em nosso estudo utilizamos como modelo o peixe paulistinha (Danio rerio), conhecido por ser altamente social, para testar aprendizagem espaco-temporal baseada em reforco social. Alem disso, objetivamos averiguar os efeitos das condicoes de claro constante e escuro constante na aprendizagem espaco-temporal, e se nessas condicoes, a atividade do peixe paulistinha e alterada. Para isso, testamos tres diferentes condicoes (n=10): grupo claro-escuro (CE), grupo claro constante (CC) e grupo escuro constante (EE) durante 30 dias da seguinte maneira: diariamente, um grupo de 5 peixes paulistinha foi introduzido em um recipiente localizado no compartimento da manha (um dos lados do aquario), as 8:00h e retirado as 9:00h, e em outro recipiente do compartimento da tarde (lado oposto do aquario), as 17:00h e removido as 18:00h, servindo como estimulo para que o peixe experimental ocupasse o compartimento onde o grupo fosse colocado. O comportamento foi filmado nos dois horarios, 15 minutos antes e durante os 60 minutos de exposicao ao estimulo, no 15o e no 30a dia, porem neste ultimo, os peixes foram filmados sem a presenca do estimulo a fim de averiguarmos a aprendizagem espaco-temporal. Por fim, para saber a influencia das tres condicoes luminosas na atividade dos peixes, filmamos os ultimos 6 dias de teste, para registrar o padrao de atividade. Nossos resultados mostraram que em ciclo claro-escuro (CE) o peixe paulistinha apresenta TPL, bem como e capaz de antecipar a hora e local do estimulo (grupo de coespecificos), enfatizando a importância do estimulo social para a aprendizagem. Em condicoes de claro constante e escuro constante, o peixe paulistinha nao apresentou aprendizagem espaco-temporal. Ademais, apos 30 dias em condicoes luminosas constantes (claro constante e escuro constante), o peixe paulistinha mantem ritmo circadiano, porem em claro constante sua atividade e aumentada e seu ritmo atividade-repouso e alterado, atraves de um padrao de atividade distribuida homogeneamente ao longo das 24h, ao inves de concentrada na subjetiva fase clara, como nos grupos de ciclo claro-escuro e escuro constante, os quais conservam o padrao de atividade diurno da especie.
A novel multi-channel photonic crystal waveguide biosensor

In this paper, we propose a two-dimensional photonic crystal multi-channel biosensor. This biosensor is implemented by a waveguide and some cavities which has the capability of highly parallel operation due to special architecture. The architecture is obtained by lattice shift of single hole around the cavities. Each channel has different resonant cavity and filling analyte to selected hole causes independently shift in resonant wavelength. Also, this biosensor has high sensitivity and quality factor. The waveguide and cavities are respectively created by omitting a raw of water holes and one hole, respectively. This biosensor is consisted from hexagonal lattice of water holes in silicon on insulator slab. Trapping DNA molecules and protein within the selected hole, causes spectral shift in the output terminal. The plane wave expansion (PWE) and finite difference time domain (FDTD) method are chosen to perform simulation.
Spatio-Temporal Distribution of Malaria in Perak, Malaysia

Malaria incidence in Perak, Malaysia has generally declined, but there remain regions of high incidence. The spatio-temporal distribution pattern of malaria in Perak was studied using Geographical Information Systems (GIS) and spatial statistical tools. Malaria data cases at the subdistrict level in Perak from 2007 to 2011 were analysed to determine the spatial and temporal distribution patterns of malaria incidence. Geographical Information Systems (GIS) and spatial statistical tools were used to identify spatial correlation in the data and malaria hot-spots. Spatial correlation was tested by using an autocorrelation method called Moran’s I. Hot spot analysis was done using Getis-Ord G* statistic technique. Malaria incidence rates were categorized into 3 classes to map the spatial distribution. Malaria cases in Perak were geo-spatially clustered. Most of the hot spots locations were in Kenering, Ulu Kinta, Gerik and Kampar sub-districts. The prevalence of malaria among foreigners was noticeably higher than Malaysians. Improved surveillance of foreign workers can prevent outbreaks and identify high risk areas. This study implies that geographic-based mapping and information system are needed for an effective malaria control.
Perceptions of Oral Errors and Their Corrective Feedback: Teachers vs. Students

Being interested in the whole process of teaching and learning a language, researchers and linguists have attempted to describe what errors and corrective feedback are, which together form an inevitable and indispensable part of instructed second and foreign language acquisition (Hendrickson, 1987). They have tried to define them in order to help learners and teachers in dealing with deviant forms that occur during speaking activities in the foreign language classroom (Nunan, 1996). Moreover, when it comes to error correction, one should not forget about a range of decisions that need to be taken into account after having noticed an error in a student’s utterance (Long, 1977). As a consequence, explaining errors and proposing the ways of rectifying incorrect forms during speaking play a vital role in students’ successes in language learning and teachers’ practices. The major aim of this paper is to report and compare teachers’ and students’ perceptions of oral errors and their corrective feedback as an inseparable part of language acquisition. The participants of the study were 43 secondary school teachers and 250 learners of English as a foreign language, who filled out questionnaires and were observed in real-life situations occurring in the language classroom. As regards the decision-making process and corrective feed-back, the analysis of the data revealed both differences and similarities in the opinions of the two groups of respondents in comparison with the actual classroom conditions, which indicate that correcting students’ erroneous forms is a complex issue meriting further investigation and consideration.
Reviews on the Influences of Alloying elements on the Microstructure and Mechanical Properties of Aluminum Alloys and Aluminum Alloy Composites

In recent year's aluminum and aluminum alloys are widely used in automotive industries. These are light weight (density of about 2.7g/cc),having good malleability and formability, high corrosion resistance and high electrical and thermal conductivity. High machinability and workability of aluminum alloys are prone to porosity due to gases dissolved during melting processes. However, in the engineering application pure aluminum and its alloys still have some problems such as relatively low strength, unstable mechanical properties. The microstructure can be modified and mechanical properties can be improved by alloying, cold working and heat treatment in this regards, this paper reports the influences of some alloying elements on the microstructures and mechanical properties of Aluminum alloys and aluminum alloy composites.
How Well Does the IS-LM Model Fit in a Developing Economy: The Case of India

The IS-LM model, as a vehicle for policy analysis, has a substantial influence on the policy makers and academicians. Like the developed countries, the IS-LM framework remains important for students to learn in the developing countries because of the benefits it offers in clarifying their thinking about the implications for practical policy issues. The main purpose of this study is to examine how well the dynamic properties of the estimated model of India match to the theoretical predictions of IS-LM model. The purpose is accomplished through Structural Vector Autoregressive (SVAR) model by estimating variance decompositions and impulse response functions. Our model explicitly accounts for the variables included in core macroeconomic models developed in the Keynesian flavour and specifies identification scheme, which capture some features of the developing economies in general. Our findings support the advocates of the IS-LM model most often compared to critics of the model.