Miracle-dz/UniFAR-FTUs huggingface dataset:
Poliovirus/Hepatitis C Virus (Internal Ribosomal Entry Site-Core) Chimeric Viruses: Improved Growth Properties through Modification of a Proteolytic Cleavage Site and Requirement for Core RNA Sequences but Not for Core-Related Polypeptides

ABSTRACT H. -H. Lu and E. Wimmer (Proc. Natl. Acad. Sci. USA 93:1412–1417, 1996) have demonstrated that the internal ribosomal entry site (IRES) of poliovirus (PV) can be functionally replaced by the related genetic element from hepatitis C virus (HCV). One important finding of this study was that open reading frame sequences 3′ of the initiating AUG, corresponding to the open reading frame of the HCV core polypeptide, are required to create a viable chimeric virus. This made necessary the inclusion of a PV 3C protease (3Cpro) cleavage site for proper polyprotein processing to create the authentic N terminus of the PV capsid precursor. Chimeric PV/HCV (P/H) viruses, however, grew poorly relative to PV. The goal of this study was to determine the molecular basis of impaired replication and enhance the growth properties of this chimeric virus. Genetic modifications leading to a different proteinase (PV 2Apro) cleavage site between the HCV core sequence and the PV polyprotein (P/H701-2A) proved far superior with respect to viral protein expression, core-PV fusion polyprotein processing, plaque phenotype, and viral titer than the original prototype PV/HCV chimera containing the PV 3Cpro-specific cleavage site (P/H701). We have used this new virus model to answer two questions concerning the role of the HCV core protein in P/H chimeric viral proliferation. First, a derivative of P/H701-2A with frameshifts in the core-encoding sequence was used to demonstrate that production of the core protein was not necessary for the translation and replication of the P/H chimera. Second, a viral construct with a C-terminal truncation of 23 amino acids of the core gene was used to show that a signal sequence for signal peptidase processing, when present in the viral construct, is detrimental to P/H virus growth. The novel P/H chimera described here are suitable models for analyzing the function(s) of the HCV elements by genetic analyses in vivo and for antiviral drug discovery.
Financial Regulations, Profit Efficiency, and Financial Soundness: Empirical Evidence from Commercial Banks of Pakistan

The purpose of this paper is threefold. First, it measures profit efficiency and financial stability of commercial banks of Pakistan. Second, it empirically estimates the effect of the already implemented financial regulations on the profit efficiency and financial stability of banks. Third, it examines the differential effect of financial regulations on profitability and financial soundness across bank size. To carry out the empirical analysis, a balanced bank-level panel data covering the period 2008-2014 is used. To gauge the profit efficiency of commercial banks, Data Envelopment Analysis (DEA) is utilised, while, to proxy the financial soundness, the Z-score is calculated for each bank. The panel regression approach is used to examine the effects of financial regulations on the profit efficiency and financial soundness of banks. We find that the financial regulations enforced by State Bank of Pakistan (SBP) have significant impacts on the profit efficiency and financial stability of banks. The results indicate that the non-performance loans to assets ratio (NPLL) and the reserve ratio (RR) impact positively, whereas, the liquidity ratio (LIQR) and the loans to deposits ratio (LODEPOSIT), significantly and negatively affect the profit efficiency of banks. However, only LR and RR are positively and significant related to the financial stability. The results also suggest that the financial regulations have significant differential effects on the profit efficiency and financial soundness of banks across bank size.
QUALITY AND TECHNOLOGY OF INDIGENOUS TRADITIONAL ‘’BIENO’’ CHEESE IN THE REGION OF MARIOVO, MACEDONIA

Bieno’’ cheese is an indigenous dairy product in Macedonia with autochthonous traditional production technology which dates back from the Ottoman Empire. The research includes and presents the results of the chemical composition and safety of raw milk used for traditional production of ‘’Bieno’’ cheese, technology and physico-chemical and microbiological quality of ‘’Bieno’’ cheese. The quality of the milk samples was determined within the permissible maximum according to data legislation. It is necessary to respect the hygienic-sanitary norms related to cultivation, preservation and care of the milking herds, and with the right technology of milking. After 45 days of ripening the researchers recorded the average results for the following parameters of the ‘’Bieno’’ cheese: moisture (38.63%), dry matter (61.37%), milk fat (26.89%), milk fat in dry matter (43.83%), proteins (26.53%), ash (9.25%), salt (5.21%) and the average of yield (9.36%). The research specified the microbiological quality of “bieno” cheese after 45 days of ripening in accordance with the special requirements of food safety regarding the microbiological criteria. Nowadays, there is a growing interest of consumers for cheeses produced with traditional technologies, usually based on handmade production, characterized by piquant, unique and specific aromas, atypical for industrial cheeses. The technology, physico-chemical and microbiological quality could be used in the protection of the origin and geographical labelling based on its unique technology. The data obtained serve as the basis for creating standardized production procedures, leading to the uniform quality of these products.
Serial Position Effects on Native Advertising Effectiveness: Differential Results Across Publisher and Advertiser Metrics

The advertising industry has recently witnessed proliferation in native ads, which are inserted into a web stream (e.g., a list of news articles or social media posts) and look like the surrounding nonsponsored contents. This study is among the first to examine native ads and unveil how their effectiveness changes across serial positions by analyzing a large-scale data set with 120 ads. For each ad, the authors use separate “natural experiment” studies to compare the ad’s performance as its serial position varies. Subsequently, they conduct a meta-analysis to generalize the results across all studies. The results reveal vastly asymmetric effects of native ad serial position on publishers’ metrics (click-based) versus advertisers’ metrics (conversion-based). As serial position lowers (i.e., from rank 1 to a lower rank), there are only modest changes in publishers’ metrics, but drastic reductions in advertisers’. This pattern is unique to native ads and has not been indicated by prior research on ad serial position. Moreover, the authors show the moderating effects of audience gender and age. The findings provide new and timely implications for researchers and marketers.
Core process management practices, quality tools and quality improvement in ISO 9001 certified manufacturing companies

Purpose – The purpose of this paper is to determine, first, the level to which ISO 9001 certified manufacturing companies adopt process management and improve quality, second, the latent factors of process management and quality improvement, and finally, the relationships between the latent factors extracted.Design/methodology/approach – A research project was carried out in 196 ISO 9001 certified manufacturing companies operating in Greece. A structured questionnaire was designed and pilot tested and then addressed to management representatives of the companies. Descriptive statistics were used in order to determine the level of process management adoption and the level of quality improvement. Exploratory and confirmatory factor analyses were also applied to extract the latent factors of process management and quality improvement and to assess their reliability and validity. The relationships between the latent factors were determined through structural equation modelling.Findings – Two latent factors we.
Self-Management on Employability Skills of Hospitality Management Students

Globalization is inevitable and Philippines as a member of ASEAN regard this reality of economic integration and interdependence. HEI’s have raised concerns regarding graduate preparedness as part of the free flow of skilled labor and are now up on their heels to meet the demand and the issue of employability of the graduates has been a significant topic. The challenges of acquiring employment of graduates after graduation mainly due to the skills gap acquired from training and demanded by the employers. The study concluded that the higher the emotional self-control, the better would be the chances of gaining employability skills.
Digital Vulnerability and Performance of Firms in Developing Countries

This paper provides evidence of large positive effects of Internet use on local firm performance, using a sample of some 30,000 firms from 38 developing and transition countries. We adopt an IV approach emphasizing firm’s digital vulnerability to seismic shocks upon the telecommunications submarine cable network, and find that a 10% increase in Internet incidence raises by 36% their total annual sales, by 26% sales per worker, by 12% the number of permanent workers. Contrary to other studies on the effect of ICT adoption on trade, we do not find significant evidence on firms’ exports. A greater use of Internet by manufactures is also found to increase their number of production (unskilled) workers in a larger extent than non-production workers, which nuances recent evidence on a skilled-biased digital revolution. The concern for omitted variable bias, reverse causality or measurement error is lowered by proceeding to a wide range of restrictions upon the sample composition and the instrument set calibration, and by controlling for location, sector, year, country-by-year fixed effects.
PENGARUH KARAKTERISTIK SISTEM INFORMASI AKUNTANSI MANAJEMEN TERHADAP KINERJA MANAJERIAL DENGAN DESENTRALISASI SEBAGAI VARIABEL MODERATING

This study was aimed to prove empirically the influence of management accounting information system characteristics consisting of broad scope, timeliness, aggregation, and integration on managerial performance with decentralization as a moderating variable. The independent variables used in this study are management accounting information system characteristics (broad scope, timeliness, aggregation, and integration), and the dependent variable used is managerial performance, and the moderating variable used is decentralization. This study uses primary data in questionnaires distributed on units of PT. Japfa Comfeed Indonesia Tbk Poultry Breeding Division Area Sumatra with respondents 35 middle managers and operational managers consisting of Lampung, Jambi, Padang and Medan. The results of this study indicate that the variable characteristics of information timeliness and aggregation effect managerial performance, while the characteristics of information broad scope and integration has no effect on managerial performance. And characteristics of management accounting information system has an effect on managerial performance. However, after being moderated by decentralization the interaction betweencharacteristics of management accounting information systems to managerial performance has no significant effect. Keywords: Management Accounting Information System Characteristics, Managerial Performance, Decentralization
Prednisone Therapy in Becker's Muscular Dystrophy

Two boys with Becker's muscular dystrophy had a dramatic and sustained improvement in strength with therapeutic use of prednisone. Both had documented Xp-21 defects on DNA testing. Concurrently with improvement, there was a decrease in their serum creatine kinase levels. One patient had two muscle biopsies, the first before prednisone treatment and the second during treatment. Both biopsies demonstrated an immunoblot decrease in the quantity of muscle dystrophin. Routine histology on the first biopsy was consistent with muscle dystrophy, and the second biopsy was normal. These two patients suggest that a small percentage of patients with Becker's muscular dystrophy have a dramatic and sustained improvement in strength with the use of therapeutic corticosteroids. All patients with Becker's muscular dystrophy should be given a careful trial of prednisone to define those who benefit. (J Child Neurol 2001;16:870—871).
Genetic Algorithm based Scan Chain Optimization and Test Power Reduction using Physical Information

In this paper, we consider genetic algorithm to optimize the scan chain length of a given circuit and minimize the power dissipation during testing. For scan chain optimization, we use layout information so as to have a more accurate modeling of scan chain lengths. At the same time, we also try to minimize the test power by reducing switching activity in the scan flip-flops during scan test operation. The scan chain is partitioned into a specified number of sub chains in order to further minimize the scan chain length, routing overhead and test power. Experimental results have been reported on ISCAS-89 benchmark circuits
Super-orbital variability of LS I +61 ◦ 303 at TeV energies

Context. The gamma-ray binary LS I +61o303 is a well-established source from centimeter radio up to very high energy (VHE; E > 100 GeV). The broadband emission shows a periodicity of ∼26.5 days, coincident with the orbital period. A longer (super-orbital) period of 1667 ± 8 days was proposed from radio variability and confirmed using optical and high-energy (HE; E ? 100 MeV) gamma-ray observations. In this paper, we report on a four-year campaign performed by MAGIC together with archival data concentrating on a search for a long-timescale signature in the VHE emission from LS I +61o303. Aims. We focus on the search for super-orbital modulation of the VHE emission, similar to that observed at other energies, and on the search for correlations between TeV emission and an optical determination of the extension of the circumstellar disk. Methods. A four-year campaign has been carried out using the MAGIC telescopes. The source was observed during the orbital phases when the periodic VHE outbursts have occurred (φ = 0.55 – 0.75, one orbit = 26.496 days). Additionally, we included archival MAGIC observations and data published by the VERITAS collaboration in these studies. For the correlation studies, LS I +61◦303 has also been observed during the orbital phases where sporadic VHE emission had been detected in the past (φ = 0.75 – 1.0). These MAGIC observations were simultaneous with optical spectroscopy from the LIVERPOOL telescope. Results. The TeV flux of the periodical outburst in orbital phases φ = 0.5 – 0.75 was found to show yearly variability consistent with the long-term modulation of ∼4.5 years found in the radio band. This modulation of the TeV flux can be well described by a sine function with a best-fit period of 1610±58 days. The complete data, including archival observations, span two super-orbital periods. There is no evidence for a correlation between the TeV emission and the mass-loss rate of the Be star, but this may be affected by the strong, short-timescale (as short as intra-day) variation displayed by the Hα fluxes.
Integrated-system to minimizing cyber harassment in kingdom of Saudi Arabia (KSA)

The proposed system framework consists two main databases: Lexicon dictionary and Summarized previous cases, by depending on Senti-ment analysis and N-Gram algorithms to match the terms and documents. In the first branch, the judge opens the cyber case and therefore the system will highlight the technical terms automatically. Furthermore, the technical terms matched with Lexicon dictionary will be high-lighted. After that, the judge opens the highlighted terms (as links), and description page will be appeared. The description page contains details about the technical terms (definitions, explanations, examples, etc). On the other side, the second branch aims to retrieve the related legal cases (from the database) judged by courts in UK and KSA. The related cases are the most closed cases to the current legal case by inserting keywords based on the current case. The judge benefits from these cases through the judgment issued to give the fair judgment. N-gram algorithm is used to find the related cases because it has smart approach to expect the most closed document and texts. The system provides the judge with laws used in issuing the judgment in KSA and UK courts.
Accelerated parameter mapping with compressed sensing : an alternative to MR fingerprinting

We introduce a method for MR parameter mapping based on three concepts: 1) an inversion recovery, variable flip angle acquisition strategy designed for speed, signal, and contrast; 2) a compressed sensing reconstruction which exploits spatiotemporal correlations through low rank regularization; and 3) a model-based optimization to simultaneously estimate proton density, T1, and T2 values from the acquired measurements. Compared to MR Fingerprinting, the proposed method achieves a five-fold acceleration in acquisition time, reconstructs an unaliased series of images, and does not rely on dictionary matching for parameter estimation.
A SURVEY ON PERSONALIZED USER SEARCH GOALS USING MULTI SEARCH ALGORITHM

Every user has their own background and a specific goal when searching of information on the web. A common problem of current web search is user search queries are short and ambiguous and insufficient way to specify user needs exactly. Current web search engine typically provide search result without considering user interest and context, we introduce an effective approach that captures the user's conceptual preferences in order to provide personalized query suggestions. In this work first we are integrating the concept of personalization and multi search to make the refined results more effective. Based on personalized data we extracting user's previous history and providing a database for user so that further refinement matches the user goals. In order to search and clustering experience SOC algorithm. Key terms- user search goals, personalized data, multisearch results, feedback sessions.
Elaboration et caracterisation de couches minces de silicium polycristallin deposees par lpcvd pour application photovoltique

Comme l'utilisations de l'energie solaire est nouvelle par rapport aux energies traditionnelles (surtout les combustibles fossiles), sa recherche et son developpement sont guides a la fois par les possibilites physiques et par les aspects economiques, politiques et sociaux. Le developpement est une rencontre d'un produit et d'un marche. Notre travail est ainsi separe en 3 parties : une partie dite de recherche horizontale concernant l'etude physique du materiau telles les caracteristiques optiques, dont nous avons etudie les principales methodes de determination des constantes optiques. Dans cette partie, nous avons detaille les deux methodes d'obtention de l'epaisseur, de l'indice de refraction et du coefficient d'absorption en fonction des longueurs d'ondes a partir du spectre de transmission seul methode de frange d'interference ; ou a partir de la combinaison des spectres de transmission et de reflexion methode dite ocs. Apres la comparaison des avantages et des inconvenients des deux methodes, nous avons abouti a une nouvelle methode qui consiste a combiner les deux methodes en meme temps afin d'augmenter la precision sur les constantes optiques. La deuxieme partie est dediee a l'application de la methode dite de minimisation, afin de calculer les proprietes optiques des couches minces de silicium amorphe obtenu par decomposition en phase vapeur a basse pression (lpcvd), de disilane, deposee dans un nouveau type de reacteur, appele reacteur puis comparees au silicium polycristallin obtenu par recuit de ce premier et au silicium polycristallin depose directement par decomposition du silane par lpcvd. Ces etudes optiques de ces differents materiaux nous ont conduit a opter pour la filiere gazeuse silane et au condition de depot de ce materiau (t = 660 c, p = 0,3torr), pour la realisation des diodes photovoltaique, et d'optimiser les epaisseurs convenable pour que 90% de la lumiere incidente soit absorbee. Dans une deuxieme etape de notre recherche nous avons etudie la cinetique de depot, les proprietes optiques, electriques, et structurales des differentes couches contribuant a la fabrication des diodes photovoltaique, a savoir les couches de silicium polycristallin non dopes, dopee bore ou phosphore. Afin de mieux comprendre les qualites de ces couches, nous avons essaye de faire un lien entre les differentes variations des parametres optiques et electriques observes et leur variation de structure en fonction de leurs epaisseurs. Pour completer ces etudes, en dernier partie, nous sommes passe a la phase dite verticale consistant a la realisation technologique de ces diodes avec un minimum d'etapes technologiques. Nous avons pu obtenir des diodes a base de silicium polycristallin avec un courant de fuite minimal et une tres bonne tenue au courant inverse jusqu'a 100v sans observer le claquage de la jonction.
Genetic Susceptibility to Sickness Absence is Similar Among Women and Men: Findings From a Swedish Twin Cohort

Previous studies of risk factors for sickness absence (SA) focus primarily on psychosocial and work environmental exposures. The aim of this study was to investigate the relative contribution of genetic influences on SA among women and men. The population-based study sample of Swedish twins (34,547) included 13,743 twin pairs of known zygosity, 3,495 monozygotic, 5,073 same-sexed dizygotic, and 5,175 opposite sexed. The point prevalence of long-term SA (≥15 days) in each zygosity and sex group was calculated. The risk of SA was estimated as an odds ratio (OR) with 95% confidence intervals (CI) where the odds for twins on SA to have a co-twin on SA was compared to the OR for SA in twins whose co-twin were not sickness absent. Intrapair correlations and probandwise concordance rates were calculated and standard biometrical genetic model-fitting methods were used to estimate the heritability of SA. The prevalence of SA was 8.8% (women 10.7%; men 6.5%). Intrapair similarity was higher among monozygotic than dizygotic twin pairs. The best-fitting model showed no sex differences in genetic effects or variance components contributing to SA. The heritability estimate was 36% (95% CI: 35–40%). Results suggest genetic contribution to the variation of SA and that environmental factors have an important role, for women and men. As SA seem to be influenced by genetic factors, future studies of associations between risk factors and SA should consider this potentially confounding effect.
Competitive Equilibrium in the Random Assignment Problem

This paper studies the problem of random assignment with fractional endowments. Fractional endowments complicate matters because the assignment has to make an agent weakly better off than his endowment. I first formulate an exchange economy that resembles the random assignment problem and prove the existence of competitive equilibrium in this economy. I then propose a pseudo-market mechanism for the random assignment problem that is based on the competitive equilibrium. This mechanism is individually rational, Pareto Optimal and justified envy-free but not incentive compatible.