Miracle-dz/UniFAR-FTUs huggingface dataset:
Cerebral Artery Vasospasm Detection Using Transcranial Doppler Signal Analysis

Silent cerebral artery vasospasm in aneurysmal subarachnoid hemorrhage causes serious complications such as cerebral ischemia and death. A transcranial Doppler (TCD) ultrasound system is a noninvasive device that can effectively detect cerebral artery vasospasm as soon as it sets in, even before and in the absence of clinical deterioration. Continuous or even daily TCD monitoring is challenging because of the operator expertise and certification required in the form of a trained sonographer and interpretive experience required in the form of an additionally trained and certified physician to perform these studies. This barrier exists because of a lack of automation for detection (without human intervention) of cerebral artery vasospasm using TCD ultrasound. To overcome this barrier, we present an algorithm that automates detection of cerebral artery vasospasm.
Comparing GBMI and non-GBMI Female Prisoners in Michigan

The guilty but mentally ill (GBMI) verdict was first adopted in Michigan in part to provide treatment for offenders suffering from mental illness. Currently, little is known of its impact among women prisoners. Therefore, the primary aim of this study was to explore if GBMI women (n = 30) spent more time on acute and residential treatment program (RTP) units in prison and/or had a higher number of violence tickets, compared with matched guilty mentally ill prisoners (non-GBMI, n = 30). The secondary aim was to characterize Axis I and Axis II disorders in GBMI female prisoners. Finally, we analyzed the data to find which Axis I and II disorders, if any, were significantly associated with violence tickets in the first year of incarceration and time in acute and RTP settings. Results showed there were no significant differences in time on acute units or the number of violence tickets between groups. Across both groups, those diagnosed with Borderline Personality Disorder had a higher number of violence tickets in the first year of prison (p < .001). The results supported the arbitrariness of the GBMI verdict in the female population and advocated for Dialectical Behavioural Therapy (DBT) programs in prisons.
Outer surface protein polymorphisms linked to host‐spirochete association in Lyme borreliae

Lyme borreliosis is caused by multiple species of the spirochete bacteria Borrelia burgdorferi sensu lato. The spirochetes are transmitted by ticks to vertebrate hosts, including small‐ and medium‐sized mammals, birds, reptiles, and humans. Strain‐to‐strain variation in host‐specific infectivity has been documented, but the molecular basis that drives this differentiation is still unclear. Spirochetes possess the ability to evade host immune responses and colonize host tissues to establish infection in vertebrate hosts. In turn, hosts have developed distinct levels of immune responses when invaded by different species/strains of Lyme borreliae. Similarly, the ability of Lyme borreliae to colonize host tissues varies among different spirochete species/strains. One potential mechanism that drives this strain‐to‐strain variation of immune evasion and colonization is the polymorphic outer surface proteins produced by Lyme borreliae. In this review, we summarize research on strain‐to‐strain variation in host competence and discuss the evidence that supports the role of spirochete‐produced protein polymorphisms in driving this variation in host specialization. Such information will provide greater insights into the adaptive mechanisms driving host and Lyme borreliae association, which will lead to the development of interventions to block pathogen spread and eventually reduce Lyme borreliosis health burden.
CA10 and CA11 negatively regulate neuronal activity‐dependent growth of gliomas

Recent studies have revealed that neurons can promote glioma growth through activity‐dependent secretion of neurotrophins, especially neuroligin‐3. It has therefore been suggested that blocking neuron‐derived neurotrophins may serve as a therapeutic intervention for gliomas. Carbonic anhydrase‐related proteins 11 and 10 (CA11 and CA10) are secreted synaptic proteins which function as neurexin ligands, and the gene‐encoding CA11 is part of a gene signature associated with radiotherapy and prognosis in gliomas. We therefore hypothesized that CA11/CA10 might participate in the neuronal activity‐dependent regulation of glioma growth. In this study, we report that CA11 secreted by depolarized cultured neurons within conditioned medium (CM) inhibited the growth of glioma cell lines. CM from depolarized neurons inhibited CA11 expression in glioma cell lines via the Akt signaling pathway. Consistently, CA11 expression was also reduced in clinical glioma samples and negatively associated with high histological grade. Low CA11 expression of gliomas was associated with short survival in four independent datasets [repository of brain neoplasia data (REMBRANDT), The Cancer Genome Atlas (TCGA) lower grade glioma (LGG), GSE4271, and GSE42669]. CA11 knockdown promoted cell growth, clone formation, and migration; inhibited apoptosis; and increased tumor size in xenografted nude mice. Similarly, CA10 and CA10 secreted by depolarized cultured neurons also inhibited the growth of glioma cell lines. Low CA10 expression was associated with short survival in REMBRANDT, TCGA LGG, and GEO GSE4271 datasets. Our results suggest that CA11 and CA10 negatively regulate neuronal activity‐dependent glioma growth and inhibit glioma aggression. Thus, CA11/CA10 may represent a potential therapeutic target for the treatment of gliomas.
Toward a Theory of HealthIT Adoption Across the Lifespan: Findings from Five Years in the Community

ABSTRACT Mediated communication enabled by information technology has immense potential to positively affect personal health. Although existing theories of technology use and adoption have advanced our understanding of information technology, they do not fully address voluntary adoption in community settings, adoption across the lifespan, and privacy concerns. Drawing on evidence collected during more than five years of field research, we start to address those issues, especially as they pertain to HealthIT (e.g. mHealth, e-Health, and/or connected health) use. Our goals include advancing theoretical discussions on technology acceptance and offering practical applications useful for medical professionals serving patients of all ages. We discuss our findings related to mandatory adoption learning heuristics, pressured voluntary adoption, digital immigrants’ self-reported technology use and skill, perceived versus actual support, concerns about online privacy and information sharing, potential loss of control over personal information, online–offline boundary incongruence, and adoption barriers related to technological features.
Thwarted belongingness and perceived burdensomeness in Korean college students: Psychometric properties and cultural considerations for the interpersonal needs Questionnaire-10

Abstract The present study aimed to validate a Korean version of the Interpersonal Needs Questionnaire in a college student sample. Three hundred and one students completed the scale and other measures of suicidal ideation, loneliness, interpersonal support, responsibility to family, meaning in life, fearlessness about death, anxiety and depression. Results revealed that the scale has two-factor structure (thwarted belongingness and perceived burdensomeness) and it also has good internal consistency, convergent validity and discriminant validity. Cultural comparisons showed that the levels of thwarted belongingness in Korean college students were higher than those in the U.S. college students.
High Global Burden and Costs of Bacterial Vaginosis: A Systematic Review and Meta-Analysis

Background Bacterial vaginosis (BV) is the most common vaginal infection among women of reproductive age and is associated with important adverse health outcomes. Estimates of the burden of BV and associated costs are needed to inform research priorities. Methods We conducted a systematic review and meta-analysis of global BV prevalence among reproductive-aged women in the general population. We searched PubMed and Embase and used random effects models to estimate BV prevalence by global regions. We estimated the direct medical costs of treating symptomatic BV. Assuming a causal relationship, we also estimated the potential costs of BV-associated preterm births and human immunodeficiency virus cases in the United States. Results General population prevalence of BV is high globally, ranging from 23% to 29% across regions (Europe and Central Asia, 23%; East Asia and Pacific, 24%; Latin America and Caribbean, 24%; Middle East and North Africa, 25%; sub-Saharan Africa, 25%; North America, 27%; South Asia, 29%). Within North America, black and Hispanic women have significantly higher (33% and 31%, respectively) prevalence compared with other racial groups (white, 23%; Asian, 11%; P < 0.01). The estimated annual global economic burden of treating symptomatic BV is US $4.8 (95% confidence interval, $3.7–$6.1) billion. The US economic burden of BV is nearly tripled when including costs of BV-associated preterm births and human immunodeficiency virus cases. Conclusions The BV prevalence is high globally, with a concomitant high economic burden and marked racial disparities in prevalence. Research to determine the etiology of BV and corresponding prevention and sustainable treatment strategies are urgently needed to reduce the burden of BV among women. Additionally, the exceptionally high cost of BV-associated sequelae highlights the need for research to understand potential causal linkages between BV and adverse health outcomes.
Thermo-viscous damping of acoustic waves in narrow channels: A comparison of effects in air and water.

Recent work in the acoustic metamaterial literature has focused on the design of metasurfaces that are capable of absorbing sound almost perfectly in narrow frequency ranges by coupling resonant effects to visco-thermal damping within their microstructure. Understanding acoustic attenuation mechanisms in narrow, viscous-fluid-filled channels is of fundamental importance in such applications. Motivated by recent work on acoustic propagation in narrow, air-filled channels, a theoretical framework is presented that demonstrates the controlling mechanisms of acoustic propagation in arbitrary Newtonian fluids, focusing on attenuation in air and water. For rigid-walled channels, whose widths are on the order of Stokes's boundary layer thickness, attenuation in air at 10 kHz can be over 200 dB m-1; in water it is less than 37 dB m-1. However, in water, fluid-structure-interaction effects can increase attenuation dramatically to over 77 dB m-1 for a steel-walled channel, with a reduction in phase-speed approaching 70%. For rigid-walled channels, approximate analytical expressions for dispersion relations are presented that are in close agreement with exact solutions over a broad range of frequencies, revealing explicitly the relationship between complex phase-speed, frequency and channel width.
THE EVOLUTION OF THE REST-FRAME V-BAND LUMINOSITY FUNCTION FROM z = 4: A CONSTANT FAINT-END SLOPE OVER THE LAST 12 Gyr OF COSMIC HISTORY

We present the rest-frame V-band luminosity function (LF) of galaxies at 0.4 ⩽ z < 4.0, measured from a near-infrared selected sample constructed from the NMBS, the FIRES, the FIREWORKS, and the ultra-deep NICMOS and WFC3 observations in the HDFN, HUDF, and GOODS-CDFS, all having high-quality optical-to-mid-infrared data. This unique sample combines data from surveys with a large range of depths and areas in a self-consistent way, allowing us to (1) minimize the uncertainties due to cosmic variance; and (2) simultaneously constrain the bright and faint ends with unprecedented accuracy over the targeted redshift range, probing the LF down to 0.1L⋆ at z ∼ 3.9. We find that (1) the faint end is fairly flat and with a constant slope from z = 4, with α = −1.27 ± 0.05; (2) the characteristic magnitude has dimmed by 1.3 mag from z ∼ 3.7 to z = 0.1; (3) the characteristic density has increased by a factor of ∼8 from z ∼ 3.7 to z = 0.1, with 50% of this increase from z ∼ 4 to z ∼ 1.8; and (4) the luminosity density peaks at z ≈ 1–1.5, increasing by a factor of ∼4 from z = 4.0 to z ≈ 1–1.5, and subsequently decreasing by a factor of ∼1.5 by z = 0.1. We find no evidence for a steepening of the faint-end slope with redshift out to z = 4, in contrast with previous observational claims and theoretical predictions. The constant faint-end slope suggests that the efficiency of stellar feedback may evolve with redshift. Alternative interpretations are discussed, such as different masses of the halos hosting faint galaxies at low and high redshifts and/or environmental effects.
MDM2 antagonist-loaded targeted micelles in combination with doxorubicin: effective synergism against human glioblastoma via p53 re-activation

Abstract p53, The tumour suppressor protein encoded by P53 gene, is the most commonly altered protein in the human malignancies. MDM2 controls the p53 activity through an autoregulatory feedback loop. p53 activates the expression of MDM2 and in return, MDM2 blocks the p53 activity through various mechanisms. Nutlins, including nutlin-3, are a new class of small molecules that bind to MDM2 and prevent its interaction with p53. This antagonism results in increased p53 activity and can also re-activates the p53 pathway and resensitize the glioblastoma cells to apoptosis. Here we used nutlin-3 in combination with another potent anticancer drug, doxorubicin, to investigate the synergism between these drugs. We encapsulated both water-insoluble drugs in the PEG-PE-based micellar nanocarriers efficiently and evaluate their efficacy against U87MG cells in 2 D and 3 D models. These nanomedicine formulations successfully re-activated the p53 levels in cells, increased the apoptosis and showed strong synergistic cytotoxic effect.
Microbiological Air Quality in Heating, Ventilation and Air Conditioning Systems of Surgical and Intensive Care Areas: The Application of a Disinfection Procedure for Dehumidification Devices

International literature data report that the increase of infectious risk may be due to heating, ventilation and air conditioning (HVAC) systems contaminated by airborne pathogens. Moreover, the presence of complex rotating dehumidification wheels (RDWs) may complicate the cleaning and disinfection procedures of the HVAC systems. We evaluated the efficacy of a disinfection strategy applied to the RDW of two hospitals’ HVAC systems. Hospitals have four RDW systems related to the surgical areas (SA1 and SA2) and to the intensive and sub-intensive care (IC and sIC) units. Microbiological air and surface analyses were performed in HVAC systems, before and after the disinfection treatment. Hydrogen peroxide (12%) with silver ions (10 mg/L) was aerosolized in all the air sampling points, located close to the RDW device. After the air disinfection procedure, reductions of total microbial counts at 22 °C and molds were achieved in SA2 and IC HVAC systems. An Aspergillus fumigatus contamination (6 CFU/500 L), detected in one air sample collected in the IC HVAC system, was eradicated after the disinfection. The surface samples proved to be of good microbiological quality. The results suggest the need for a disinfection procedure to improve the microbiological quality of the complex HVAC systems, mostly in surgical and intensive care areas.
Ischemic Preconditioning, O2 Kinetics, and Performance in Normoxia and Hypoxia

Introduction Ischemic preconditioning (IPC) before exercise has been shown to be a novel approach to improve performance in different exercise modes in normoxia (NORM). Few studies have been conducted examining potential mechanisms behind these improvements, and less has been done examining its influence during exercise in hypoxia (HYP). Oxygen uptake and extraction kinetics are factors that have been implicated as possible determinants of cycling performance. We hypothesized that IPC would lead to improvements in oxygen extraction and peripheral blood flow kinetics, and this would translate to improvements in cycling time trial (TT) performance in both NORM and HYP. Methods Thirteen men (age, 24 ± 7 yr; V˙O2max, 63.1 ± 5.1 mL·kg−1·min−1) participated in the study. Subjects completed trials of each combination of normobaric HYP (FiO2 = 0.16, simulating ~8000 ft/2500 m) or NORM (FiO2 = 0.21) with preexercise IPC protocol (4 × 5 min at 220 mm Hg) or SHAM procedure. Trials included submaximal constant load cycle exercise bouts (power outputs of 15% below gas exchange threshold, and 85% of V˙O2max), and a 5-km cycling performance TT. Results Ischemic preconditioning significantly improved 5-km TT time in NORM by 0.9% ± 1.8% compared with SHAM (IPC, 491.2 ± 35.2 s vs SHAM, 495.9 ± 36.0 s; P < 0.05). Ischemic preconditioning did not alter 5-km TT performance times in HYP (P = 0.231). Ischemic preconditioning did, however, improve tissue oxygen extraction in HYP (deoxygenated hemoglobin/myoglobin: IPC, 21.23 ± 10.95 &mgr;M; SHAM, 19.93 ± 9.91 &mgr;M; P < 0.05) during moderate-intensity exercise. Conclusions Our data confirm that IPC is an effective ergogenic aid for athletes performing 5-km cycling TT bouts in NORM. Ischemic preconditioning did mitigate the declines in tissue oxygen during moderate-intensity exercise in HYP, but this did not translate to a significant effect on mean group performance. These data suggest that IPC may be of benefit for athletes training and competing in NORM.
Forefoot and hindfoot kinematics in subjects with medial tibial stress syndrome during walking and running

Excessive foot pronation during static standing, walking and running has been reported as a contributing factor for the development of medial tibial stress syndrome (MTSS). The motion of foot pronation consists of hindfoot and forefoot motion. However, no previous studies have investigated forefoot and hindfoot kinematics during walking and running in subjects with MTSS. The current study sought to compare hindfoot and forefoot kinematics between subjects with and without MTSS while walking and running. Eleven subjects with MTSS and 11 healthy controls (each group containing 10 males and one female) participated in the current study. Segment angles of the hindfoot and forefoot during walking and running barefoot on a treadmill were recorded using three‐dimensional kinematic analysis. An independent t‐test was used to compare kinematic data between groups. Subjects with MTSS exhibited significantly greater hindfoot eversion and abduction (p < 0.05) during walking and running than subjects without MTSS, significantly greater forefoot eversion and abduction (p < 0.05) during walking, and significantly greater forefoot abduction during running (p < 0.05). Hindfoot and forefoot kinematics during walking and running were significantly different between subjects with and without MTSS. For prevention and rehabilitation of MTSS, it may be important to focus on not only hindfoot but also forefoot kinematics during both running and walking. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res
Intersectional internalized stigma among Black gay and bisexual men: A longitudinal analysis spanning HIV/sexually transmitted infection diagnosis

Internalized stigma undermines health among people diagnosed with HIV and other sexually transmitted infections (STI), yet limited research has examined how internalized stigma develops. Black gay and bisexual men (n = 151) reported their race and sexual orientation internalized stigma once before HIV/STI diagnosis and their HIV/STI internalized stigma monthly for 1 year after HIV/STI diagnosis. Multilevel analyses demonstrated that race and sexual orientation internalized stigma before diagnosis were associated with greater HIV/STI internalized stigma after diagnosis. More research is needed to understand how internalized stigma develops, including within the context of other identities and broader environmental characteristics to inform intervention efforts.
Determination of minimum inhibitory concentrations for silver sulfadiazine and other topical antimicrobial agents against strains of Pseudomonas aeruginosa isolated from canine otitis externa

BACKGROUND Otitis externa is a common presenting complaint in practice. Ear infections by Pseudomonas aeruginosa are particularly problematic due to the organism's high level of resistance and ability to damage the tympanum. Treatment should be based on susceptibility testing although minimum inhibitory concentrations (MICs) are not available for all treatment options. Silver sulfadiazine has been used in cases of recurrent P. aeruginosa otitis, although a MIC for silver sulfadiazine as a single agent has not been established. OBJECTIVES To describe susceptibility patterns of P. aeruginosa isolated from canine otitis externa and determine the MIC for silver sulfadiazine and other topical antimicrobials. ANIMALS Thirty-six P. aeruginosa isolates were collected from client-owned dogs, suffering from otitis externa. METHODS AND MATERIALS Susceptibility patterns were established using disc diffusion susceptibility testing against 17 antimicrobial agents. For determination of the MIC, selected strains were tested against increasing concentrations of marbofloxacin, enrofloxacin, gentamicin, polymyxin B and silver sulfadiazine using broth microdilution. RESULTS For nine of 17 antimicrobial agents, complete resistance was seen in all isolates tested via disk diffusion susceptibility testing. Approximately 94% and 96% of isolates were susceptible to gentamicin and imipenem, respectively. These findings were consistent with broth dilution, where all strains were susceptible to gentamicin. Resistance was higher against polymyxin B and the fluoroquinolones. Silver sulfadiazine was effective in vitro with a MIC ranging from 1 to 64 μg/mL. CONCLUSIONS AND CLINICAL SIGNIFICANCE As the MIC of silver sulfadiazine was lower than the concentration in a 1% preparation, such a product potentially represents a treatment option for dogs with P. aeruginosa otitis.
Word-context associations in episodic memory are learned at the conceptual level: Word frequency, bilingual proficiency, and bilingual status effects on source memory.

Three source-memory experiments were conducted with Spanish-English bilinguals and monolingual English speakers matched on age, education, nonverbal cognitive ability and socioeconomic status. Bilingual language proficiency and dominance were assessed using standardized objective measures. In Experiment 1, source was manipulated visuo-spatially, in Experiment 2, source was manipulated temporally, and in Experiment 3, source was manipulated by presenting stimuli in different modalities. Bilingual source discrimination was more accurate for low-frequency words than for high-frequency words, but it did not differ for the more fluent and less fluent languages (L1 and L2, respectively). These results contrast with the L2 advantage observed in item recognition (Francis & Gutiérrez, 2012; Francis & Strobach, 2013), adding to evidence that the bases of performance for item and source memory differ. The dissociation of word frequency and language effects indicates that word-context associations are made at the conceptual level rather than the word-form level. Bilinguals exhibited more accurate source discrimination than monolinguals, both under intentional and incidental encoding conditions, indicating that this effect cannot be explained entirely by differences in encoding strategies. We reason that relative to monolinguals, bilinguals more efficiently encode associations between word concepts and contexts or other types of information that do not convey meaning preexperimentally. (PsycINFO Database Record (c) 2018 APA, all rights reserved).