Miracle-dz/UniFAR-FTUs huggingface dataset:
Exploring factors influencing voluntary turnover intent of Generation X public servants: A South African case

Purpose: The purpose of this article is to report on the factors perceived to influence the turnover intent of Generation X public servants. The problem: The researcher investigated the factors that Generation X public servants in South Africa perceive as influencing their turnover intent. Design: The problem was studied by way of a case study. The data were collected by means of semi-structured interviews. A total of eight purposively selected Generation X public servants participated in this study. Findings: The findings of the study show that the factors influencing the turnover intent of the Generation X public servants correspond to some of those proposed in the literature, including the nature of the job, traditional attitudes, and organisational context, both on the macro- and the micro-levels. Furthermore, these factors are also congruent with the drivers of engagement as set out in the literature, specifically content, coping, compensation, community and career. One of the implications of the findings of this study is that although the value of employees to organisations were established as long ago as the Renaissance, organisations still do not capitalise on their most important asset. It is in particular the direct (line) manager that plays a crucial role in optimising the value-add of employees. Value: This study is original as it was the first to investigate the turnover intentions of Generation X public servants. Generation X employees are important as they are deemed to be the knowledge repositories of organisations and they are next in line to support the organisation when the Baby Boomers retire. The perceived turnover intentions correspond to some of the components of the generic turnover model proposed by Holtom et al. (2008). The question that arises is whether the turnover intentions of Generation X are any different from other generations. Conclusions: Given their unique characteristics, Generation X is a turnover risk, which is facilitated by employee mobility. The line manager has control over all the components influencing turnover intent, while engagement is omnipresent in these components. It is the role and responsibility of the line manager to facilitate engaged employees, which would equate to affectively committed employees, by attending to these components. In so doing the line manager can prevent the costly implications of employee turnover while capitalising on their value to the organisation.
The sustainability of healthcare innovations: a concept analysis.

AIM To report on an analysis of the concept of the sustainability of healthcare innovations. BACKGROUND While there have been significant empirical, theoretical and practical contributions made towards the development and implementation of healthcare innovations, there has been less attention paid to their sustainability. Yet many desired healthcare innovations are not sustained over the long term. There is a need to increase clarity around the concept of innovation sustainability to guide the advancement of knowledge on this topic. DESIGN Concept analysis. DATA SOURCES We included literature reviews, theoretical and empirical articles, books and grey literature obtained through database searching (ABI/INFORM, Academic Search Complete, Business Source Complete, CINAHL, Embase, MEDLINE and Web of Science) from 1996-May 2014, reference harvesting and citation searching. METHODS We examined sources according to terms and definitions, characteristics, preconditions, outcomes and boundaries to evaluate the maturity of the concept. RESULTS This concept is partially mature. Healthcare innovation sustainability remains a multi-dimensional, multi-factorial notion that is used inconsistently or ambiguously and takes on different meanings at different times in different contexts. We propose a broad conceptualization that consists of three characteristics: benefits, routinization or institutionalization, and development. We also suggest that sustained innovations are influenced by a variety of preconditions or factors, which are innovation-, context-, leadership- and process-related. CONCLUSION Further conceptual development is essential to continue advancing our understanding of the sustainability of healthcare innovations, especially in nursing where this topic remains largely unexplored.
Effect of cimetidine on the disposition of rimantadine in healthy subjects

Twenty-three healthy male and female subjects received single 100-mg oral doses of rimantadine hydrochloride on two occasions in an open-label, sequential design with a 6-day washout between doses. The first dose of rimantadine was administered alone, and the second dose was administered concomitantly with cimetidine (300 mg four times a day for 6 days). Blood and urine samples were collected, and rimantadine concentrations were determined by a gas-chromatographic--mass-spectrometric method. There were no changes in the rate of absorption and the renal clearance of rimantadine when it was administered with cimetidine. Both parametric and nonparametric tests showed significant differences in the area under the concentration-time curve, apparent total clearance, and elimination rate constant between the treatments (P less than 0.01). The apparent total clearance was reduced by 18%, resulting in higher values for the area under the concentration-time curve in the presence of cimetidine. However, the wide therapeutic index of rimantadine renders these changes of little, if any, clinical consequence.
The Real Effects of Mandatory Non-Financial Disclosures in Financial Statements

We examine the real effects of mandatory, non-financial disclosures, introduced into securities regulation under the Dodd-Frank Act, which require firms to disclose their mine-safety records in their financial reports. Most, if not all, of the information included in these disclosures was already publicly available, which allows us to examine the incremental effects of including the information in financial reports. Comparing mines owned by SEC-registered issuers to those mines that are not, we document that the disclosures are associated with an approximately 11 percent decrease in both mining-related citations and injuries. We also find suggestive evidence that productivity declines. Using short-window return tests around disclosures of citations, we show that markets price mine-safety information and that financial statement disclosure appears to incrementally increase investors’ awareness of safety issues. Overall, our results suggest that there are real effects of disclosing non-financial information in financial statements—even if this information is publicly available elsewhere.
Retrospective Study Multidisciplinary Care of Unruptured Brain Arteriovenous Malformations to Improve Symptomatic Headache and the Onset , Progression , and Outcomes of Unruptured Brain Arteriovenous Malformations

Methods: The demographics, clinical features, imaging features, and headache details of eligible patients were reviewed. An 11-point pain scale score was used to assess symptomatic headaches before, during, and after treatment. The headache outcomes, death or stroke, and adverse functional outcomes (modified Rankin Scale score ≥ 2, mRS ≥ 2) were assessed following multidisciplinary care of ubAVMs.
Uniform Deviation Bounds for k-Means Clustering

Uniform deviation bounds limit the difference between a model’s expected loss and its loss on a random sample uniformly for all models in a learning problem. In this paper, we provide a novel framework to obtain uniform deviation bounds for unbounded loss functions. As a result, we obtain competitive uniform deviation bounds for k-Means clustering under weak assumptions on the underlying distribution. If the fourth moment is bounded, we prove a rate of O ( m− 1 2 ) compared to the previously known O ( m− 1 4 ) rate. We further show that this rate also depends on the kurtosis — the normalized fourth moment which measures the “tailedness” of the distribution. We also provide improved rates under progressively stronger assumptions, namely, bounded higher moments, subgaussianity and bounded support of the underlying distribution.
Migration of traumatic intracranial subdural hematoma to lumbar spine causing radiculopathy

Background: There have been rare reports of intracranial subdural hematoma (SDH) that migrated into the spine. All previous cases have been surgically managed and in this case report, we describe the first case of conservatively managed spinal hematoma secondary to migratory intracranial SDH. Case Description: A 26-year-old male presented with a left tentorial SDH after blunt trauma. He was conservatively managed and discharged home. He presented 8 days later with worsening lower back pain that was found to be secondary to a spinal SDH. Conclusion: Spinal hematomas can be a serious sequelae of migrated intracranial hematomas. Tentorial and other caudally located intracranial hematomas may be more prone to this phenomenon.
CORRESPONDENCE OF INTERESTS AND SELF-EFFICACY BELIEFS WITH OCCUPATIONAL CHOICE

Person-environment (P-E) congruence and its relation to study satisfaction and academic achievement were examined. Two interest measures and one self-efficacy measure were used to represent RIASEC personality types. The Croatian version of Personal Globe Inventory was administrated on a sample of 630 university students. The congruence indices have shown that students' future occupations are almost equally related to their interests as to their self-efficacy beliefs. P-E congruence shares less than 1% of common variance with study satisfaction and academic achievement, regardless of the RIASEC personality measures used to estimate the congruence.
Ceftaroline Increases Membrane Binding and Enhances the Activity of Daptomycin against Daptomycin-Nonsusceptible Vancomycin-Intermediate Staphylococcus aureus in a Pharmacokinetic/Pharmacodynamic Model

ABSTRACT New antimicrobial agents and novel combination therapies are needed to treat serious infections caused by methicillin-resistant Staphylococcus aureus (MRSA) with reduced susceptibility to daptomycin and vancomycin. The purpose of this study was to evaluate the combination of ceftaroline plus daptomycin or vancomycin in an in vitro pharmacokinetic/pharmacodynamic model. Simulations of ceftaroline-fosamil at 600 mg per kg of body weight every 8 h (q8h) (maximum free-drug concentration in serum [fCmax], 15.2 mg/liter; half-life [t1/2], 2.3 h), daptomycin at 10 mg/kg/day (fCmax, 11.3 mg/liter; t1/2, 8 h), vancomycin at 2 g q12h (fCmax, 30 mg/liter; t1/2, 6 h), ceftaroline plus daptomycin, and ceftaroline plus vancomycin were evaluated against a clinical, isogenic MRSA strain pair: D592 (daptomycin susceptible and heterogeneous vancomycin intermediate) and D712 (daptomycin nonsusceptible and vancomycin intermediate) in a one-compartment in vitro pharmacokinetic/pharmacodynamic model over 96 h. Therapeutic enhancement of combinations was defined as ≥2 log10 CFU/ml reduction over the most active single agent. The effect of ceftaroline on the membrane charge, cell wall thickness, susceptibility to killing by the human cathelicidin LL37, and daptomycin binding were evaluated. Therapeutic enhancement was observed with daptomycin plus ceftaroline in both strains and vancomycin plus ceftaroline against D592. Ceftaroline exposure enhanced daptomycin-induced depolarization (81.7% versus 72.3%; P = 0.03) and killing by cathelicidin LL37 (P < 0.01) and reduced cell wall thickness (P < 0.001). Fluorescence-labeled daptomycin was bound over 7-fold more in ceftaroline-exposed cells. Whole-genome sequencing and mutation analysis of these strains indicated that change in daptomycin susceptibility is related to an fmtC (mprF) mutation. The combination of daptomycin plus ceftaroline appears to be potent, with rapid and sustained bactericidal activity against both daptomycin-susceptible and -nonsusceptible strains of MRSA.
Physicists' Views on Hadrontherapy: A Survey of Members of the Italian Association of Medical Physics (AIFM)

Background This study was based on a survey to investigate perceptions of hadrontherapy of the members of the Italian Association of Medical Physics (AIFM). The survey was digitally submitted to the 991 members between the end of January and the beginning of April 2016. Methods A 19-item questionnaire was designed focusing on advantages and disadvantages of hadrontherapy, current status and possible future improvements, and need and opportunities for future investments in Italy and abroad. Information about professional qualifications, main fields of clinical involvement and specific competencies of the respondents was also collected. Results The survey was completed by 121 AIFM members (response rate 12.2%). In the answers collected, it was shown that medical physicists expressed interest in hadrontherapy mainly for reasons of personal interest rather than for professional needs (90% ± 2.5% vs. 52% ± 4.3% of the respondents, respectively), with a good knowledge of the related basic aspects as well as of the pros and cons of its application. However, poor knowledge of the current status of hadrontherapy was observed among the medical physicists not directly involved at a professional level, who were less than 3% of the physicists working in radiotherapy. Conclusions In light of these results, the implementation of new training and education initiatives should be devised to promote a deeper and global knowledge of hadrontherapy-related issues, not only from a theoretical point of view but also in practical terms. Moreover, a close collaboration between highly specialized medical physicists employed in hadrontherapy centers and others in oncology hospitals should be encouraged.
Measuring Reporting Conservatism

The paper examines the power and reliability of the differential timeliness (DT) measure developed by Basu (1997) to gauge reporting conservatism. We identify certain characteristics of the information environment unrelated to conservatism that affect the DT measure and find that it is sensitive to the degree of uniformity in the content of the news during the examined period, the types of events occurring in the period, and firms' disclosure policies. Our tests, based on both actual and simulated data, indicate that assessing the extent of reporting conservatism using this measure requires the recognition of, and control for, these characteristics. We also find that the difference in the timeliness of reporting bad versus good news is likely to be more pronounced than previously reported. Further, we provide additional evidence on the negative association between the DT measure and alternative aspects of conservatism, suggesting that the exclusive reliance on any single measure to assess the overall cons.
Improving phone recognition performance via phonetically-motivated units

This paper examines how phonetically-motivated units affect the performance of phone recognition systems. Focusing on the realization of /h/, which is one of the most frequently error-making phones in Korean phone recognition, three different phone sets are designed by considering optional phonetic constraints which show complementary distributions. Experimental results show that one of the proposed sets, the h-deletion set improves phone recognition performance compared to the baseline phone recognizer. It is noteworthy that this set needs no additional phonetic unit, which means that no more HMM is necessary to be modeled, accordingly it has the advantage in terms of model size. Besides, it obtains competent performance compared to the baseline system in terms of word recognition as well. Thus, this phonetically-motivated approach dealing with improvement of phone recognition performance is expected to be used in embedded solutions which require fast and light recognition process.
Load Balancing in Home-Based Software DSMS

Load balancing is a critical issue for achieving good performance in parallel and distributed systems. However, this issue is neglected in the research area of software DSMs in the past decade. Based on the observation that scientific applications can be classified into two categories: iterative and non-iterative, we propose two dynamic scheduling schemes for these two cases respectively in this paper. For iterative scientific applications, a dynamic task migration technique is proposed which characterizes itself with integrating computation migration and data migration together. An affinity-based self scheduling (ABS) is proposed for non-iterative scientific applications, which take both the static and dynamic processor affinity into consideration when scheduling. The target experiment platform is a state-of-the-art home-based DSM system named JIAJIA. Performance evaluation results show that the novel task migration scheme improves the performance ranging from 36% to 50% compared with a static task allocation scheme in a metacomputing environment, and performs better than traditional task (computation-only) migration approach about 12.5% for MAT, and 37.5% for SOR and EM3D. Higher resource utilization is achieved via the new task migration scheme too. In comparison with other loop scheduling schemes, the ABS achieves the best performance among all scheduling schemes in a metacomputing environment because of the reduction of synchronization overhead and the great improvement of waiting time resulting from load imbalance.
DenseCut: Densely Connected CRFs for Realtime GrabCut

Figure‐ground segmentation from bounding box input, provided either automatically or manually, has been extremely popular in the last decade and influenced various applications. A lot of research has focused on high‐quality segmentation, using complex formulations which often lead to slow techniques, and often hamper practical usage. In this paper we demonstrate a very fast segmentation technique which still achieves very high quality results. We propose to replace the time consuming iterative refinement of global colour models in traditional GrabCut formulation by a densely connected crf. To motivate this decision, we show that a dense crf implicitly models unnormalized global colour models for foreground and background. Such relationship provides insightful analysis to bridge between dense crf and GrabCut functional. We extensively evaluate our algorithm using two famous benchmarks. Our experimental results demonstrated that the proposed algorithm achieves an order of magnitude (10×) speed‐up with respect to the closest competitor, and at the same time achieves a considerably higher accuracy.
Contribution of germline mutations to PARK2 gene inactivation in lung adenocarcinoma

Homozygous germline mutations of the PARK2 gene are responsible for the development of early‐onset Parkinson's disease (PD). Homozygous PARK2 mutations have been also detected in lung adenocarcinoma (LADC). However, since heterozygous PARK2 germline mutations are present in a subset of non‐PD individuals, the timing for the occurrence of two‐hit PARK2 mutations in LADC progression is unclear. Therefore, we comprehensively analyzed mutations, expression and copy number variations of the PARK2 gene in 267 primary LADCs together with the corresponding noncancerous lung cells and 39 LADC cell lines. Heterozygous germline exonic deletions were detected in five patients with LADC, and loss of heterozygosity including the PARK2 locus was detected in 31/267 (11.6%) LADCs. However, homozygous PARK2 inactivation was not detected in any of them, including the five patients with germline mutations. Homozygous PARK2 inactivation was detected in 6/39 (15%) cell lines, two exonic deletions, one exonic duplication, and three point mutations, while heterozygous PARK2 inactivation was detected in two cell lines (both by exonic deletions). These results strongly indicate that somatic PARK2 mutations occur rarely (or do not occur) in LADC development and that germline PARK2 mutations could contribute to LADC progression but not to LADC development. © 2012 Wiley Periodicals, Inc.
Human Skeletal Growth and Age Determination

Problemes poses par les etudes de squelettes prehistoriques sub-adultes (âge, sexe, maladies retardant la croissance, tendance seculaire dans la maturation, manque du standard dentaire propre a la determination de l'âge, petit nombre d'individus dans certaines classes d'âge, etat incomplet des squelettes). Comparaison des croissances d'Europeens du Moyen Age et d'Indiens nord-americains.
California’s Nurse-to-Patient Ratios, Part 3: Eight Years Later, What Do We Know About Patient Level Outcomes?

OBJECTIVE: The objective of this study was to describe the impact of California’s nurse-to-patient ratios on patient-level outcomes from a comprehensive literature review. BACKGROUND: While implemented in 2004, questions remain about the effects the ratios have had on patients. METHODS: A comprehensive literature review was conducted. RESULTS: Patient outcome results are mixed in the 8 identified studies, with 3 studies finding both positive and negative outcomes and 5 studies reporting no significant changes in patient outcomes. CONCLUSIONS: Findings from this review suggest some improvements have resulted from the implementation of staffing ratios, but the positives have not been as significant and widespread as predicted. Further studies are needed to explore the relationship between patient outcomes and mandated staffing levels in this state and other settings.
FEMALE BIASED PARASITISM AND THE IMPORTANCE OF HOST GENERATION OVERLAP IN A SEXUALLY TRANSMITTED PARASITE OF BEETLES

Sexual transmission is a widespread means of infection, but apart from those in humans, the ecology of sexually transmitted organisms is not well known. In this study, we present an ecological study of a sexually transmitted mite, Parobia husbandi Seeman and Nahrung (Acari: Podapolipidae), that lives beneath the elytra of Chrysophtharta agricola (Chapuis) (Coleoptera: Chrysomelidae). In each of 2 yr, prevalence of mites on beetles began each spring at about 10–20% but gradually increased to 80–100% by late summer. Overlap of adult beetle generations at this time (i.e., the parental generation mating with the F1 generation) is essential for the persistence of these mites. Mites exhibited temporal change in their spatial distribution on beetles; these changes were probably a response to beetle activity (e.g., emergence from diapause) and the need for dispersal from parental to F1 generation beetles. Prevalence and mean intensity of mites was higher on female beetles compared with male beetles. Female bias of sexually transmitted infection has been predicted in animals but hitherto observed only in primates. We speculate that variable male mate-finding success is the cause of these sex-based differences of mite infections, and that female bias in sexually transmitted disease (STD) infection will be widespread in the animal kingdom.