Miracle-dz/UniFAR-FTUs huggingface dataset:
Expression of the caudal-type homeodomain transcription factors CDX 1/2 and outcome in carcinomas of the ampulla of Vater.

PURPOSE Adenocarcinomas of the ampulla of Vater demonstrate a characteristic histology but vary significantly in outcome. As a consequence, prognostic factors for these cancers are poorly defined. The caudal-type homeodomain transcription factors 1 (CDX1) and 2 (CDX2) regulate axial development and intestinal differentiation. We assessed the expression of these putative intestinal epithelial-specific transcription factors and their influence on patient outcome. PATIENTS AND METHODS Fifty-three resected carcinomas of the ampulla of Vater, 31 pancreatic ductal adenocarcinomas, and 15 extrahepatic biliary carcinomas were analyzed for CDX1 and CDX2 expression using immunohistochemistry. RESULTS Forty percent of carcinomas of the ampulla of Vater but less than 5% of pancreatic and biliary adenocarcinomas expressed CDX. Expression of CDX was associated with a better prognosis (P = .0009). Individually, both CDX1 (P = .02) and CDX2 (P = .02) expression were associated with a survival advantage on univariate analysis. Advanced T stage (P = .02), lymph node metastases (P = .004), and vascular space invasion (P = .0009) were associated with a poor prognosis. Multivariate analysis revealed vascular space invasion (P = .01) and CDX expression (P = .01) to be independent prognostic factors. CONCLUSION Expression of CDX was an independent marker of outcome in patients with resected adenocarcinoma of the ampulla of Vater. Expression of CDX may distinguish good prognosis intestinal-like tumors, which potentially arise within intestinal epithelium, from poorer prognosis pancreatobiliary tumors, which arise in adjacent pancreatic and/or biliary ductal epithelium.
Leadership Practices of Principals of Selected Public Secondary Schools in Kathmandu, Nepal

Academic performance of students from most of the public schools in Nepal is not satisfactory. However, there are a few public schools consistently performing well despite similar students’ and teachers’ backgrounds, infrastructure and resources. This study explored how principals’ understandings and practices of their leadership role may have influenced students’ learning. For this study five higher performing and five lower performing schools from Kathmandu Metropolitan City (KMC) were chosen. In-depth interviews and separate focus group discussions were conducted with the principals. Findings were analyzed under six dimensions of effective school leadership identified from the literature: (a) vision building and goal setting, (b) crafting positive school culture, (c) supporting teachers and students, (d) developing leadership among staff, (e) managing resources, and (f) leading for continuous improvement. All principals identified challenges in their work, but the principals from lower performing schools identified more challenges. Principals from higher performing schools typically provided more comprehensive accounts of their roles as school leaders.
Photoperiodic responses of broilers. I. Growth, feeding behaviour, breast meat yield, and testicular growth

1. A total of 7960 Cobb and Ross broiler males were reared in two trials to 35 d on various photoperiods between 2 and 21 h or under continuous illumination; a total of 444 birds were randomly selected at 35 d and retained for subsequent determination of breast meat yield and testicular weight at 40 or 54 d of age. 2. In both strains, feed intake and growth were positively correlated with photoperiod during the first 21 d, but afterwards feed intake was not significantly affected by photoperiods longer than 6 h and growth was negatively correlated with photoperiod beyond 12 h. Overall, to 35 d, there were no significant photoperiodic influences on either feed intake or growth for ≥6-h photoperiods, but significant depressions in feed intake and growth for photoperiods shorter than 6 h. Feed conversion efficiency was maximised by 12-h photoperiods, with decreases in efficiency above and below 12 h. Mortality was unaffected by photoperiod <12 h, but increased proportionately with photoperiod >12 h. The incidence of Sudden Death Syndrome (SDS) had an inverse relationship with photoperiod ≤10 h, but was positively correlated with photoperiod >10 h. The European Efficiency Factor was curvilinearly related to photoperiod, with the highest efficiency occurring at 12 h. Ross birds had significantly greater feed intakes but poorer feed conversion efficiencies than Cobb; differences in growth, overall mortality and the incidence of SDS between the strains were not significantly different. 3. By 5 d, birds given ≤15 h illumination had learned to eat in the dark, with the amount of feed consumed being inversely proportional to photoperiod; further increases in the amount of nocturnal feeding occurred between 5 and 20 d for ≤12-h photoperiods. The mean hourly rate of nocturnal feeding was consistently lower than diurnal feeding, irrespective of photoperiod. Nocturnal feeding patterns were similar for both genotypes. 4. Breast meat yield at 40 d was unaffected by photoperiod in Cobb birds, but significantly higher in continuously illuminated Ross birds than ≤21 h. At 54 d, breast meat yield was significantly higher in both genotypes given 21 h or continuous illumination and, overall, higher than at 40 d. 5. Testicular weights at 40 and 54 d of age increased with photoperiod in both genotypes to 12 or 15 h. Thereafter, weights plateaued for Cobb but decreased for Ross as the photoperiod was further extended to continuous illumination. 6. New EU welfare regulations come into effect on 30 June 2010 and these state that meat-chickens must have at least 6 h of darkness in each 24-h period, i.e. a maximum photoperiod of 18 h; compliance with the regulations should have no adverse effect on either performance or profitability.
Leadership and Lean Six Sigma: a systematic literature review

The term ‘Lean Six Sigma’ refers to the integration of ‘Lean’ and ‘Six Sigma’ business improvement methodologies, where ‘Lean’ is a process improvement methodology used to deliver products and services better, faster and at a lower cost, while ‘Six Sigma’ is a data-driven methodology used to achieve stable and predictable processes. The concept of ‘Lean Six Sigma’ as an integrated strategy is still in development: since its inception in 2000, a number of academics have developed an integrated approach, while others have focused on a framework for the successful integration of Lean and Six Sigma. Despite becoming the most popular business strategy for deploying continuous improvement, many organisations are struggling to turn Lean Six Sigma into a success, citing lack of leadership, changing business focus, internal resistance and availability of resources as the main impeding factors. The focus of this research was to consolidate the existing knowledge on leadership and Lean Six Sigma, providing a starting point for researchers and practitioners seeking to implement Lean Six Sigma in organisations and offering suggestions for future research. This systematic literature review aims to synthesise, organise and structure the stock of knowledge relating to Lean Six Sigma and leadership. The research is based on a systematic literature review of 179 papers that were published on leadership, Lean and Six Sigma in well-known academic databases in the past 20 years. The key findings of the review show that (1) leadership is a requirement for successful Lean Six Sigma deployment in organisations, and critical to sustaining improvement and (2) Lean Six Sigma is an effective leadership development tool. Leadership is a critical factor for Lean Six Sigma success and there is the need to develop a new model of leadership that encompasses the leadership traits needed for Lean Six Sigma.
Severe hypoglycaemia and glycaemic control in Type 1 diabetes: meta‐analysis of multiple daily insulin injections compared with continuous subcutaneous insulin infusion

1 The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993; 329: 977–986. 2 NICE. Diabetes in Pregnancy: Management of Diabetes and its Complications from Pre-conception to the Postnatal Period. NICE guidelines. London: National Institute of Clinical Excellence, July 2008. 3 Alberti K, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus—provisional report of a WHO consultation. Diabet Med 1998; 15: 539–553. 4 Kjos SL, Buchanan TA. Current concepts: gestational diabetes mellitus. N Engl J Med 1999; 341: 1749–1756. 5 UK Prospective Diabetes Study (UKPDS) Group. Intensive blood glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with Type 2 diabetes (UKPDS 33). Lancet 1998; 352: 837–853. 6 Reinblatt SL, Morin L, Meltzer SJ. The importance of a post-partum 75 g oral glucose tolerance test in women with gestational diabetes. J Obstet Gynaecol Can 2006; 28: 690–694.
Phosphofructokinase: structure and control.

Phosphofructokinase from Bacillus stearothermophilus shows cooperative kinetics with respect to the substrate fructose-6-phosphate (F6P), allosteric activation by ADP, and inhibition by phosphoenolpyruvate. The crystal structure of the active conformation of the enzyme has been solved to 2.4 A resolution, and three ligand-binding sites have been located. Two of these form the active site and bind the substrates F6P and ATP. The third site binds both allosteric activator and inhibitor. The complex of the enzyme with F6P and ADP has been partly refined at 2.4 A resolution, and a model of ATP has been built into the active site by using the refined model of ADP and a 6 A resolution map of bound 5'-adenylylimidodiphosphate (AMPPNP). The $\gamma$ -phosphate of ATP is close to the 1-hydroxyl of F6P, in a suitable position for in-line phosphoryl transfer. The binding of the phosphate of F6P involves two arginines from a neighbouring subunit in the tetramer, which suggests that a rearrangement of the subunits could explain the cooperativity of substrate binding. The activator ADP is also bound by residues from two subunits.
Neurophysiological Manifestations of Recollective Experience during Recognition Memory Judgments

Decisions regarding whether an item has been previously encountered are typically accompanied by one of two distinct forms of subjective awareness: either a general sense of familiarity, or conscious recollection of specific details from a prior study episode. To examine the neurophysiological concomitants of these different types of internal experience, event-related potentials (ERPs) were recorded while subjects engaged in a modified recognition memory procedure that required them to describe their subjective response during each testtrial. Stimuli that evoked recollection were accompanied by waveforms distinct from those that evoked only a sense of familiarity, and waveforms for both categories of correctly classified old items differed from correctly rejected distractor items and incorrectly classified (missed) studied items. These ERP responses are interpreted with respect to current knowledge concerning the neural structures and processes intimately involved in the capacity to engage in recollection.
How Resource Phenology Affects Consumer Population Dynamics

Climate change drives uneven phenology shifts across taxa, and this can result in changes to the phenological match between interacting species. Shifts in the relative phenology of partner species are well documented, but few studies have addressed the effects of such changes on population dynamics. To explore this, we develop a phenologically explicit model describing consumer-resource interactions. Focusing on scenarios for univoltine insects, we show how changes in resource phenology can be reinterpreted as transformations in the year-to-year recursion relationships defining consumer population dynamics. This perspective provides a straightforward path for interpreting the long-term population consequences of phenology change. Specifically, by relating the outcome of phenological shifts to species traits governing recursion relationships (e.g., consumer fecundity or competitive scenario), we demonstrate how changes in relative phenology can force systems into different dynamical regimes, with major implications for resource management, conservation, and other areas of applied dynamics.
A New Larval Tray and Rack System for Improved Mosquito Mass Rearing

ABSTRACT The requirement for efficient mosquito mass rearing technology has been one of the major obstacles preventing the large scale application of the Sterile Insect Technique against mosquitoes. At the Food and Agriculture Organization/International Atomic Energy Agency (FAO/IAEA) Insect Pest Control Laboratories we developed a larval rearing unit based on the use of a stainless steel rack that operates 50 thermoformed ABS plastic trays and is expected to be able to successfully rear 140,000–175,000 Anopheles arabiensis (Patton) adult mosquitoes per rack. The mechanized rearing unit is simple to handle, maintains minimal water temperature variation and negligible water evaporation and allows normal larval development. The mosquito mass-rearing tray was designed to provide a large surface area of shallow water that would closely mimic natural breeding sites. The trays stack into a dedicated rack structure and filling and draining were easily performed. The close stacking of the trays in the rack and the possibility to tightly line up several racks makes this rearing unit a valid solution for maximal use of the space thus reducing construction, heating, and cooling costs. The low amount of labor required to operate the system also reduces labor costs that represent one of the main expenditures in any mass rearing facility operation. Preliminary experiments performed on Aedes albopictus (Skuse) also confirm the possibility of successfully extending the use of this technology to other mosquito species. Our larval rearing unit could enhance any mosquito control strategy in which large-scale releases of mosquitoes are needed to suppress or replace natural populations.
Seroreactivity to bacterial antigens is not a unique phenomenon in patients with autoimmune thyroid diseases in Canada.

It has been suggested elsewhere that the enteric pathogen Yersinia enterocolitica (Y.e.) might be implicated etiologically in autoimmune thyroid disease (AITD). To reevaluate this hypothesis in the Canadian population, where the prevalence of anti-Y.e. antibodies in the general population is very low (< 1%), we have studied the occurrence of antibacterial reactivity (against Y.e. 0:3 and 0:9, Escherichia coli and Staphylococcus aureus) in the sera of patients with Hashimoto's thyroiditis (HT), Graves' disease (GD), nontoxic nodular goiter (NTG), and autoimmune rheumatic diseases (ARD) as well as normal controls (C). Using the tube agglutination method, no single positive sample was detected in these subjects. No differences in the mean levels of anti-Y.e. 0:3 or 0:9 by ELISA were observed between various groups of patients. Immunoreactivity in the course of medical therapy during 5-12 months did not show significant changes in any of 12 ARD and AITD patients. Some serological reactivity to the plasmid containing strain of Y.e. 0:3 was demonstrated in all subjects by the Western blotting technique. However, weaker signals and fewer bands were noticed in these sera compared to sera from patients with acute yersiniosis. Analysis of the pattern of reactivity did not show any difference in reactivity to any protein between the groups of subjects. The immunodominant antigen in Y.e. 0:3 to which IgG reacted in almost all subjects was the plasmid encoded 240-kDa protein. Our study favors the view that there is a merely coincidental incidence of seroreactivity to bacterial antigens, which appears to be irrespective of diagnosis.
Effects of antiplatelet therapy on platelet extracellular vesicle release and procoagulant activity in health and in cardiovascular disease

Abstract Dual antiplatelet therapy with aspirin and clopidogrel is commonly used to prevent recurrent ischemic events in patients with cardiovascular disease. Whilst their effects on platelet reactivity are well documented, it is unclear, however, whether antiplatelet therapy inhibits platelet extracellular vesicle (EV) release. The aim of this study was to investigate the effects of antiplatelet therapy on platelet EV formation and procoagulant activity. Blood samples from 10 healthy controls not receiving antiplatelet therapy were incubated in vitro with aspirin or a P2Y12 inhibitor (MeSAMP). Blood samples from 50 patients receiving long-term dual antiplatelet therapy and undergoing coronary angiography were also studied. Platelet reactivity was assessed by Multiplate™ impedance aggregometry. Platelet EV formation and procoagulant activity of pretreated and untreated blood samples in response to arachidonic acid (AA), adenosine diphosphate (ADP), ADP+PGE1, and thrombin receptor-activating peptide (TRAP) stimulation were assessed by flow cytometry and Procoag-PL assays, respectively. Incubation of normal platelets with aspirin significantly inhibited AA-induced platelet reactivity, EV formation, and procoagulant activity, whilst MeSAMP significantly inhibited platelet reactivity and EV formation in response to AA, ADP, and TRAP, but had minimal effect on procoagulant activity. Most patients receiving dual antiplatelet therapy showed an appropriate reduction in platelet reactivity in response to their treatment; however there was not complete inhibition of increased platelet and EV procoagulant activity in response to ADP, AA, or TRAP. In addition, we could not find any correlation between platelet reactivity and procoagulant activity in patients receiving dual antiplatelet therapy.
Socio-economic status scales updated for 2017

The health status of any country depends on the socio-economic status (SES) and the per capita income of its citizens. The SES also decides the affordability and utilization of the health facilities. Constant changes in the price of goods in the country due to inflation make it mandatory to constantly update the income-based socioeconomic scales. This paper attempts to provide updates in Kuppuswamy, B.G. Prasad and udai pareek socioeconomic scales for 2017.
PREFERENSI INDIVIDU MUSLIM DALAM PENYALURAN ZAKAT, INFAK, SHADAQAH DAN WAQAF (ZISWA): KENDALA PEMBANGUNAN SEKTOR KETIGA

In a muslim dominated region, management of zakaf infaq, shadaqah, and waqf (ZISWA) is the third (community) sector activity which serves as an instrument to enhance people welfare. Unfortunately, the third sector development through the implementation of ZISWA instrument is constrained by the phenomenon of limited collected ZISWA funds in amil institution - a non profit organization as an actor in this sector. This phenomenological qualitative research showed that the phenomenon is caused by (1) the preference of ZISWA payers (donors) who tend to pay their ZISWA directly to the recipient; (2) the lack of some muslim awareness to pay their ZISWA; (3) limited financial owned by donors; and (4) the weaknesses of amil institution. The low level of trust towards amil institution is also a constraint of this sector development. It is suggested to do public socialization on the amil existence as well as what and how to accomplish ZISWA. In addition, the improvement of amil institutional governance is a must.
What the Literature Tells Us about Listeners' Reactions to Stuttering: Implications for the Clinical Management of Stuttering

It is known that listeners harbor negative stereotypes toward people who stutter but there are a host of other findings in the literature that provide a broader perspective about how listeners react to stuttering. The focus of this article is a discussion of four areas of research related to listener reactions to stuttering: (1) how stuttering impacts listeners' reactions to mild, moderate, and severe stuttering; (2) how stuttering interferes with listener recall and comprehension of story information; (3) how children react to stuttering; and (4) how listeners react to strategies plus use in stuttering therapy programs. Studies associated with these four areas of research are summarized and discussed. Clinical implications that emerge from these studies are described to assist clinicians in the treatment of children and adults who stutter.
Comparative Alveolar Ridge Preservation Using Allogenous Tooth Graft versus Free-dried Bone Allograft: A Randomized, Controlled, Prospective, Clinical Pilot Study

Background: For the first time in India, allografts from human extracted teeth were prepared. A randomized, prospective, clinicoradiographical, histological study was conducted to evaluate their efficacy in comparison with freeze-dried bone allograft (FDBA) in alveolar ridge preservation. Materials and Methods: Graft preparation: with written consent, teeth were collected from three donors (full mouth extraction cases). Once donors' serums were tested negative for HIV, HBV, HCV, and Venereal disease research laboratory (VDRL), mineralized whole tooth allograft (WTA) and dentin allograft (DA) were prepared using the standard protocol of Tissue Bank at Tata Memorial Hospital, Mumbai, India. Study Design: In this randomized controlled trial, 15 patients undergoing extraction of at least four teeth were selected. In each patient after atraumatic extractions, one socket was grafted with WTA, second with DA, third with FDBA, and fourth was left ungrafted (control site). All the sites were covered with chorion membrane. To estimate three-dimensional alveolar crest changes, cone beam computed tomography scans were taken immediately after grafting and 4 months postoperatively. Bone biopsies using 3 mm trephine bur were obtained from four patients at the time of implant placement and evaluated histologically. Results: Clinically uneventful healing was observed at all sites. Compared to other sites, WTA and DA consistently showed superior results demonstrating least reduction in alveolar crest height and width which was statistically significant (P < 0.05). Between WTA and DA sites, there was no statistically significant difference. Histological analysis also confirmed more new bone formation at WTA and DA sites. Conclusions: Rather than disposing extracted human teeth as a biomedical waste (common practice), they can be collected from suitable systemically healthy donors. With the help of tissue bank, they can be processed into an allograft, serving as an excellent alternative to conventional allografts.
The Emerging Role of p38 Mitogen-Activated Protein Kinase in Multiple Sclerosis and Its Models

ABSTRACT Multiple sclerosis (MS), the most common disabling neurologic disease of young adults, is considered a classical T cell-mediated disease and is characterized by demyelination, axonal damage, and progressive neurological dysfunction. The currently available disease-modifying therapies are limited in their efficacy, and improved understanding of new pathways contributing to disease pathogenesis could reveal additional novel therapeutic targets. The p38 mitogen-activated protein kinase (MAPK) signaling pathway is known to be triggered by stress stimuli and to contribute to inflammatory responses. Importantly, a number of recent studies have identified this signaling pathway as a central player in MS and its principal animal model, experimental allergic encephalomyelitis. Here, we review the evidence from mouse and human studies supporting the role of p38 MAPK in regulating key immunopathogenic mechanisms underlying autoimmune inflammatory disease of the central nervous system and the potential of targeting this pathway as a disease-modifying therapy in MS.