Miracle-dz/UniFAR-FTUs huggingface dataset:
Immune Thrombocytopenic Purpura Detected with Oral Hemorrhage: a Case Report

Immune thrombocytopenic purpura (ITP) is an immune-mediated acquired disease found in both adults and children. It is characterized by transient or persistent decreases in the platelet count. We report a case of ITP detected based on oral hemorrhagic symptoms. The patient was a 79-year-old female with no significant past medical history. She presented with sudden onset of gingival bleeding and hemorrhagic bullae on the buccal mucosa. Gingival bleeding was difficult to control. Laboratory tests revealed severe thrombocytopenia with a platelet count as low as 2000/μL. Under a provisional diagnosis of a hematological disorder, she was referred to a hematologist. A peripheral smear showed normal-sized platelets. A bone marrow examination revealed increased numbers of megakaryocytes without morphologic abnormalities. The patient was diagnosed with ITP and treated with a combination of pulsed steroid therapy and high-dose immunoglobulin therapy. However, her severe thrombocytopenia was refractory to these treatments. Then, a thrombopoietin receptor agonist was begun as a second-line treatment. Her platelets rapidly increased, and no bleeding complications were reported. Because oral symptoms can be one of the initial manifestations of ITP, dentists should be familiar with the clinical appearance of ITP, and attention must be paid to detect and diagnose unidentified cases.
A large supernumerary bone at the bregma and metopism co-occurring in the skull of an ancient roman in Serbia

An unusual anatomical variation was observed on a skull excavated at Laniste (Raska district, Serbia), a Roman necropolis dating back to the second half of the 4th century AD. The skull of an adult male showed a remarkably large supernumerary bone at the bregma co-occurring with a continuous persistent metopic suture. Few similar cases have been reported in scientific literature. We describe the case and discuss possible mechanisms and underlying causes, including pathological conditions. [Projekat Ministarstva nauke Republike Srbije, br. 177007 i br. 177021: Urbanization processes and development of medieval society]
Affirmative practice with transgender and gender nonconforming youth: Expanding the model.

Affirmative care with transgender and gender nonconforming (TGNC) children and adolescents is a new framework under which many mental health clinicians now practice. It rests on a premise that appreciates diverse gender expressions and identities within society, and encourages the highest potential for individuals to follow their own paths to positive emotional well-being. Scientific understanding of the phenomenology of gender development in children and adolescents is scarce, and the gaps in knowledge limit evidence-based practice when working with these youths. Interventions span many domains within the physical and mental health realms, calling for providers to navigate differing interdisciplinary perspectives when optimizing assessment and treatment goals. In addition, interventions differ according to developmental stage, and newer approaches and treatments have become more popular within the last decade. For children, the concept of social gender transition has remained controversial, as relatively historical approaches (discouraging cross-gender behavior) have become outdated and more recent methods (supporting gender transition) have gained backing. Fully reversible pubertal suppression has been introduced for TGNC adolescents as a means of buying time for exploration without the pressures of irreversible pubertal advancement. Given the current deficits in scientific understanding of genderidentity development in youth, the affirmative provider often faces decisions that are challenging, complex, and unclear. This paper describes the theoretical approaches to TGNC youth across development, provides a brief overview of the current research, and offers providers a way to conceptualize and provide care that can be both supportive and scientifically driven when done in a thoughtful, balanced way.
Ghd7 (Ma6) Represses Sorghum Flowering in Long Days: Ghd7 Alleles Enhance Biomass Accumulation and Grain Production

Sorghum Ma6, a strong repressor of flowering in long days (LDs), was identified as the CONSTANS, CO‐like, and TOC1 (CCT)‐domain protein encoded by SbGhd7. Sorghum Ghd7 increases photoperiod sensitivity and delays flowering by inhibiting expression of the floral activator SbEhd1 and genes encoding FT. SbGhd7 expression is light‐dependent and gated by the circadian clock. In LDs when flowering is repressed, SbGhd7 mRNA abundance peaks in the morning and evening. In short days (SDs) when floral initiation occurs, the evening phase of SbGhd7 expression occurs in darkness, reducing SbGhd7 mRNA abundance. In energy sorghum hybrids, dominant alleles of SbGhd7 and SbPRR37 act in additive fashion to delay floral initiation for ∼175 d until daylengths decrease below 12.3 h. In contrast, photoperiod‐insensitive grain sorghum genotypes containing recessive alleles of SbGhd7 and SbPRR37 flower in 60 to 80 d. Recessive alleles of SbGhd7 and SbPRR37 are present in historically important sorghum germplasm introduced into the United States in the 1800s that was used to produce early flowering grain and sweet sorghum. Recessive alleles ghd7‐1 and prr37‐1 are present in maturity standards such as SM100, and in BTx406, a genotype used in the Sorghum Conversion Program to convert late‐flowering photoperiod‐sensitive sorghum accessions into early flowering photoperiod‐insensitive germplasm useful for grain sorghum breeding. The results show that alleles of SbGhd7 confer differences in photoperiod sensitivity and flowering times that are critical for production of late‐flowering high‐biomass energy sorghum and early flowering grain sorghum.
Variability of Bacterial Essential Genes Among Closely Related Bacteria: The Case of Escherichia coli

The definition of bacterial essential genes has been widely pursued using different approaches. Their study has impacted several fields of research such as synthetic biology, the construction of bacteria with minimal chromosomes, the search for new antibiotic targets, or the design of strains with biotechnological applications. Bacterial genomes are mosaics that only share a small subset of gene-sequences (core genome) even among members of the same species. It has been reported that the presence of essential genes is highly variable between closely related bacteria and even among members of the same species, due to the phenomenon known as “non-orthologous gene displacement” that refers to the coding for an essential function by genes with no sequence homology due to horizontal gene transfer (HGT). The existence of dormant forms among bacteria and the high incidence of HGT have been proposed to be driving forces of bacterial evolution, and they might have a role in the low level of conservation of essential genes among related bacteria by non-orthologous gene displacement, but this correlation has not been recognized. The aim of this mini-review is to give a brief overview of the approaches that have been taken to define and study essential genes, and the implications of non-orthologous gene displacement in bacterial evolution, focusing mainly in the case of Escherichia coli. To this end, we reviewed the available literature, and we searched for the presence of the essential genes defined by mutagenesis in the genomes of the 63 best-sequenced E. coli genomes that are available in NCBI database. We could not document specific cases of non-orthologous gene displacement among the E. coli strains analyzed, but we found that the quality of the genome-sequences in the database is not enough to make accurate predictions about the conservation of essential-genes among members of this bacterial species.
Rice farmers’ technical efficiency under abiotic stresses in Bangladesh

This study was an attempt to investigate the economic performance of stress tolerant rice varieties in different abiotic stress prone areas (submergence, drought, and salinity) of Bangladesh. The study used production frontier approach to measure the technical efficiency at the farm level. Benefit-cost analysis revealed that farmers in all stress environments obtained positive margin on cash cost basis and the profit became negative on full cost basis in all environments with exception for submergence. That means rice production was marginally benefited to farmers in all the stress environments. Farm specific technical efficiency of all stress environments indicated that large farmers were comparatively more efficient due to their economic solvency as they could apply adequate amount of inputs in due time with proper doses. Inefficiency model indicated that farm size, farmers ‘education, households’ size, farming experience, extension contact, and main occupation of the farmers, were the important factors causing variations in the efficiency. However, BRRI released stress tolerant rice varieties had significant positive impact on technical efficiency. Plausible policies have been recommended according to the study outcomes.
In Vitro and In Silico Studies of the Molecular Interactions of Epigallocatechin-3-O-gallate (EGCG) with Proteins That Explain the Health Benefits of Green Tea

Green tea has been shown to have beneficial effects on many diseases such as cancer, obesity, inflammatory diseases, and neurodegenerative disorders. The major green tea component, epigallocatechin-3-O-gallate (EGCG), has been demonstrated to contribute to these effects through its anti-oxidative and pro-oxidative properties. Furthermore, several lines of evidence have indicated that the binding affinity of EGCG to specific proteins may explain its mechanism of action. This review article aims to reveal how EGCG-protein interactions can explain the mechanism by which green tea/EGCG can exhibit health beneficial effects. We conducted a literature search, using mainly the PubMed database. The results showed that several methods such as dot assays, affinity gel chromatography, surface plasmon resonance, computational docking analyses, and X-ray crystallography have been used for this purpose. These studies have provided evidence to show how EGCG can fit or occupy the position in or near functional sites and induce a conformational change, including a quaternary conformational change in some cases. Active site blocking, steric hindrance by binding of EGCG near an active site or induced conformational change appeared to cause inhibition of enzymatic activity and other biological activities of proteins, which are related to EGCG’s biological oligomer and formation of their toxic aggregates, leading to the prevention of neurodegenerative diseases and amyloidosis. In conclusion, these studies have provided useful information on the action of green tea/catechins and would lead to future studies that will provide further evidence for rational EGCG therapy and use EGCG as a lead compound for drug design.
Climate and Nothofagus pumilio Establishment at Upper Treelines in the Patagonian Andes

Due to its climate sensitivity, the upper treeline offers a unique opportunity to document variations in forest dynamics in response to current climate change. It is generally accepted that the expansion of the upper treeline is limited by cold temperatures. Consequently, warmer conditions in the context of global warming are expected to induce an advance of forests into alpine vegetation. To complement previous studies in the North Patagonia treeline, we conducted a study in the southern Patagonian Andes to: 1) characterize the temporal patterns of Nothofagus pumilio establishment in the upper treeline along a precipitation gradient, 2) establish the relationship between variations in regional climate and tree establishment, and 3) determine the influence of continental and hemispheric-scale climatic forcing on tree establishment at regional scale. At El Chalten-Laguna del Desierto area, the N. pumilio establishment above the upper treelines started at the mid-1970s and reached two peaks in the late 1980s-early 1990s and around the year 2000. Although tree establishment followed similar patterns along the precipitation gradient, we noted some differences between wet and dry forests. Whereas at the wettest sites the largest establishment peak occurred in the most recent, relatively-dry period, tree recruitment was more abundant in the earliest humid period at the driest treelines. Our studies suggest that the location of the N. pumilio upper treeline in the Patagonian Andes is sensitive to changes in climate. The increment in temperature during the past decades has facilitated tree recruitment; however, the rate of seedling establishment appears to be modulated by interactions between the temperature increase and variations in precipitation. The expansion of the upper treeline is mostly limited to 5-10 m from the abrupt treeline suggesting that seed dispersal and winds modulate the rate of spatial advance. While the recent expansion of the upper treeline in northern Patagonia was regulated by temperature and precipitation variations associated with the different phases of the Pacific Decadal Oscillation, the climatic variations induced by the positive trend of the Southern Annular Mode during the last decades have facilitated the establishment above the upper treeline in the southern Patagonian Andes.
Development and Evaluation of a Prototype web XBRL-Enabled Financial Platform for the Generation and Presentation of Financial Statements according to IFRS

The main objective of IFRS is to provide a common qualitative accounting basis and to promote greater transparency and comparability of financial reporting across the world. However, the success of IFRS depends on how financial information flows within the company and in which format is represented to outside users. Therefore, accounting information systems and web financial applications should meet the qualitative criteria of IFRS. Also, it is necessary to introduce new advanced technologies that will be able to electronically describe the new "business language", XBRL. The purpose of this paper is to study accountants’ perceptions to use eXtensible Business Reporting Language (XBRL), investigating the implications of implementing an XBRL project in the Greek capital market. In addition, a pilot model for Web financial reporting, using XBRL, was developed and specifically evaluated. The results indicated that this pilot model is a financial environment where accountants can easily and quickly find, parse, edit and exchange useful and meaningful accounting information. This empirical study revealed that both: a) Greek companies by their prospective adoption of XBRL b) Greek capital market by implementing a sophisticated web financial reporting model seek for the generation and presentation of high quality accounting data.
Alignment of Vertically Grown Carbon Nanostructures Studied by X-Ray Absorption Spectroscopy

X-Ray Absorption Spectroscopy (XAS) on the carbon K edge of carbon nanostructures (nanotubes, nanofibers, nanowalls) is reported here. They are grown on plain SiO2 (8 nm thick)/Si(100) substrates by a Plasma and Hot Filaments-enhanced Catalytic Chemical Vapor Deposition (PE HF CCVD) process. The morphology and the nature of these carbon nanostructures are characterized by SEM, TEM and Raman spectroscopy. According to conditions of catalyst preparation and DC HF CCVD process, carbon nanotubes (CNTs), carbon nanofibers (CNFs), carbon nanowalls (CNWs), carbon nanoparticles (CNPs) with different orientation of the graphene plans or shells can be prepared. From the angular dependence of the incident light and geometrical morphology of the nanostructures, wide variations of the C K-edge intensity of the transitions to the empty π* and σ* states occur. A full lineshape analysis of the XAS spectra has been carried out using a home-made software, allowing estimating the relative proportion of π* and σ* transitions. A geometrical model of the angular dependence with the incidence angle of the light and the morphology of the carbon nanostructures is derived. With normalization to the HOPG (Highly Oriented Pyrolytic Graphite graphite) reference case, a degree of alignment can be extracted which is representative of the localized orientation of the graphitic carbon π bonds, accounting not only for the overall orientation, but also for local defects like impurities incorporation, structural defects . This degree of alignment shows good agreement with SEM observations. Thus CNTs films display degrees of alignment around 50%, depending on the occurrence of defects in the course of the growth, whereas no special alignment can be detected with CNFs and CNPs, and a weak one (about 20%) is detected on CNWs.
CORRELATION OF ANKLE DORSIFLEXION RANGE OF MOTION WITH DYNAMIC BALANCE IN YOUNG NORMAL INDIVIDUALS

1184 Original Article CORRELATION OF ANKLE DORSIFLEXION RANGE OF MOTION WITH DYNAMIC BALANCE IN YOUNG NORMAL INDIVIDUALS Pranali Suryavanshi 1, Ajay kumar 2, Parag Kulkarni 3, Prakash Patel *4. 1 Intern, DPO’s NETT college of Physiotherapy, Thane (W), Maharashtra, India. 2 Principal, DPO’s NETT College of Physiotherapy, Thane (W), Maharashtra, India. 3 Associate professor, DPO’s NETT College of Physiotherapy, Thane (W), Maharashtra, India. *4 Lecturer, SPB Physiotherapy College, Surat, Gujarat, India.
Effect of Fractioning on Antibacterial Activity of Enantia chlorantha Oliver (Annonaceae) Methanol Extract and Mode of Action

Infectious diseases caused by bacteria constitute the main cause of morbidity and mortality throughout the world and mainly in developing countries. In this work, the influence of fractioning and the mode of action of stem barks methanol extract of Enantia chlorantha were investigated. The aim was to optimize the antibacterial activity of the methanol extract. The extract was prepared by maceration of barks powder in methanol. Fractioning was done using increasing solvents polarity. Standard phytochemical methods were used for phytochemical screening. Minimum Inhibitory Concentrations (MIC) and Minimum Bactericidal Concentration (MBC) of the methanol extract and fractions were determined using broth microdilution method. The studied mode of action of both methanol extract and n-butanol fraction included antibiofilm activity, H+-ATPase-mediated proton pumping assay, salt tolerance, and cells cycle. The methanol extract of E. chlorantha stem barks was found to be active on all the bacteria tested (32 ≤ MIC ≤ 512 μg/mL), its activity being significant (MIC < 100 μg/ml) out of 5 of the 28 clinical isolates used. Salmonella enterica serovar paratyphi A was the most sensitive (32 μg/mL). Compared to the extract and other fractions, the n-butanol fraction was found to be more active (32 ≤ MIC ≤ 256). Significant antibacterial activity of this fraction was observed out of 10 of the 28 bacterial isolates and 3 out of 7 bacterial strains. Lowest MIC values (32 μg/ml) of this fraction were obtained with Escherichia coli (136), Pseudomonas aeruginosa (CIP 76110), and Salmonella enterica serovar typhi 9. The methanol extract of E. chlorantha and its n-butanol fraction revealed several modes of action including the prolongation of the latency phase of the bacterial growth, the inhibition of the pump with protons H+ - ATPases bacterial, the loss of the salt tolerance of the Staphylococcus aureus, and inhibition of the formation of the bacterial biofilm. The present results showed that the n-butanol fraction of the methanol stem barks extract of E. chlorantha possess the essential antibacterial components and could best be used to fight against bacterial infections as compared to methanol extract.
A Pharmacological Update of Ellagic Acid

Abstract Ellagic acid is a common metabolite present in many medicinal plants and vegetables. It is present either in free form or as part of more complex molecules (ellagitannins), which can be metabolized to liberate ellagic acid and several of its metabolites, including urolithins. While ellagic acidʼs antioxidant properties are doubtless responsible for many of its pharmacological activities, other mechanisms have also been implicated in its various effects, including its ability to reduce the lipidemic profile and lipid metabolism, alter pro-inflammatory mediators (tumor necrosis factor-α, interleukin-1β, interleukin-6), and decrease the activity of nuclear factor-κB while increasing nuclear factor erythroid 2-related factor 2 expression. These events play an important role in ellagic acidʼs anti-atherogenic, anti-inflammatory, and neuroprotective effects. Several of these activities, together with the effect of ellagic acid on insulin, glycogen, phosphatases, aldose reductase, sorbitol accumulation, advanced glycation end-product formation, and resistin secretion, may explain its effects on metabolic syndrome and diabetes. In addition, results from recent research have increased the interest in ellagic acid, both as a potential protective agent of the liver and skin and as a potential anticancer agent, due to the specific mechanisms affecting cell proliferation, apoptosis, DNA damage, and angiogenesis and its aforementioned anti-inflammatory properties. Taken together, these effects make ellagic acid a highly interesting compound that may contribute to different aspects of health; however, more studies are needed, especially on the compoundʼs pharmacokinetic profile. In this review, we selected papers published from 2005 to the present.
Efficacy Beliefs in Third-Person Effects

People generally believe they are less susceptible than others to influences of media, and a growing body of research implicates such biased processing, or third-person perception, in public support for censorship, a type of third-person effect. The current study extends research of the third-person effect by studying two efficacy-related concepts in the context of sexual content in films. Analysis of cross-sectional data from 1,012 Singaporeans suggests that people exhibit self-other asymmetries of efficacy beliefs: They believe others are less capable than they are of self-regulation and that censorship is more effective at restricting others’ access to sexual content in films. Furthermore, the former belief was directly related to the belief that others are more susceptible to negative influence, and thus was indirectly related to support for censorship; whereas the latter belief was directly related to support for censorship. Results may help distinguish the roles of self-regulation and government censorship as bases of local media standards.