Miracle-dz/UniFAR-FTUs huggingface dataset:
The Impact of Stereoscopic Depth on the Munker-White Illusion

The current study investigated the impact of stereoscopic depth information on adults' perception of a coloured version of the Munker–White illusion. In one half of the illusory figure red patches were embedded in black stripes and flanked by yellow stripes. In the other half of the illusory figure red patches were embedded in yellow stripes and flanked by black stripes. The red patches either remained in the same depth plane as the black and yellow inducing stripes (zero horizontal disparity condition) or were shifted into the foreground (crossed horizontal disparity condition) or into the background (uncrossed horizontal disparity condition). According to the results, the illusory effect was robust across all viewing conditions. The illusion mainly consisted of a subjective darkening of the red patches superimposed on the yellow stripes, a perceived hue shift of the red patches superimposed on the black stripes toward yellow, and a subjective saturation decrease in both kinds of red patches. Moreover, the study established a partial confirmation of Anderson's scission theory, according to which the Munker–White illusion should be largest in the crossed horizontal disparity condition, intermediate in the zero horizontal disparity condition, and smallest in the uncrossed horizontal disparity condition.
Quantification of Early Subclinical Limited Joint Mobility in Diabetes Mellitus

Limited joint mobility (LJM) has been described in juvenile diabetic patients by Rosenbloom et al.; similar abnormalities are also present in adult diabetes. This modification may be associated with a high risk of microvascular complications. We tested the use of a goniometer in measuring subclinical joint limitation in 50 adult diabetic patients without overt, i.e., clinically evident, LJM as described by these authors. This diabetic population was compared with 118 nondiabetic adult controls. We found significant changes in hand mobility between the two groups for wrist flexion and extension of the 3rd and 5th fingers (P < 0.001). Age was correlated to wrist flexion, wrist extension, and proximal interphalangeal flexion of the little finger. Wrist extension correlated with duration of diabetes (r = − 0.37, P < 0.01). Heavy manual activities significantly limited all motions except wrist and 5th finger metacarpophalangeal flexion. Early systematic examination by goniometry may prove to be a sensitive, quantitative, and inexpensive way of detecting joint stiffness at an early stage.
Genetic and phenotypic relationships between ovulation rate and body weight in the mouse.

The genetic and phenotypic regressions and correlations between ovulation rate and body weight were examined in a random bred strain (Q) of laboratory mice during the course of three experiments. These experiments were (1) a sib analysis; (2) selection for natural and induced primiparous ovulation rate; and (3) replicated selection for 6-week weight. The following results were obtained: ( a ) The genetic correlations between body weight and natural and induced ovulation rate were positive, and approximately equal to 0·4 and 0·6 respectively. ( b ) The genetic regressions of natural and of induced ovulation rate on body weight were approximately 0·4 and 0·9 eggs per gram respectively. ( c ) The genetic regressions of body weight on natural and on induced ovulation rate were approximately 0·5 and 0·25 g per egg respectively. ( d ) The phenotypic correlation between natural ovulation rate and body weight was approximately 0·4 and the corresponding regression of ovulation rate on body weight approximately 0·4 eggs per gram. ( e ) The phenotypic correlation between induced ovulation rate and body weight declined from 0·4 at 6 weeks of age to zero at the time of scoring, the corresponding regressions of ovulation rate on body weight declining from 0·1 eggs per gram to zero. It was concluded that natural ovulation rate itself, and both its components (FSH activity and ovarian sensitivity) are positively genetically correlated with body weight. Furthermore, the observation that large mice shed at least as many eggs as small ones in response to the same dose of PMS showed that the response was more closely related to the absolute dose than to the resultant concentration.
Establishment and characterization of a pluripotent stem cell line derived from human amniotic membranes and initiation of germ layers in vitro

OBJECTIVES: Pluripotent stem cells are proposed to be used in regenerative therapy and may exist in the human amniotic membrane. The present article is aimed at establishing a pluripotent stem cell line from human placenta. METHODS: HAM-1 (stem cell line derived from human amniotic membranes) was established by the colonial cloning technique using α MEM culture medium containing long/ml of EGF, 10ng/ml of hLIF and 10% fetal bovine serum. RESULTS: HAM-1 cells appeared to maintain a normal karyotype indefinitely in vitro and expressed markers characteristic of stem cells from mice and human, namely alkaline phosphatase. Also, these cells contributed to the formation of chimeric mouse embryoid bodies and gave rise to cells of all germ layers in vitro. CONCLUSIONS: This study demonstrates that human amniotic membranes derived stem cells have a wide developmental capability and might be utilized to regenerate different types of cells or tissues for transplantation therapy.
Neural adaptive regulation of unknown nonlinear dynamical systems

With this paper we extend our previous work on the subject, by including the case where the number of control inputs is different from the number of states which is frequently faced in control engineering problems. Uniform ultimate boundedness of the state and uniform boundedness of all other signals in the closed loop is guaranteed. Robustness of our algorithm due to the presence of a modeling error term which has linear growth with unknown growth coefficient is also established. Finally, the applicability of our control scheme is highlighted via simulation results.
An Alu Element in the Myeloperoxidase Promoter Contains a Composite SP1-Thyroid Hormone-Retinoic Acid Response Element*

An Alu element preceding the myeloperoxidase gene (MPO) contains four hexamer motifs related to the consensus recognition sequence for nuclear hormone receptors (AGGTCA), arranged as direct repeats with spacing of 2, 4, and 2 nucleotides (DR-2-4-2). Gel shift experiments and transient transfection assays demonstrate that these sequences include binding sites for retinoic acid and thyroid hormone receptors and function in vivo to activate transcription of a chloramphenicol acetyltransferase reporter gene. The first DR-2 elements of the series do not bind known receptors but do bind the SP1 transcription factor. Two alleles of the MPO gene exist that differ at one position within this element, resulting in one allele with and one without a strong SP1 binding site. The element with the SP1 site activates transcription by 25-fold in transient transfection assays, while the alternative allele confers severalfold less transcriptional activity. Most cases of acute myelocytic leukemia are homozygous for the allele with the SP1 binding site, suggesting this element plays an important role in regulating the MPO gene in myeloid leukemias. This MPO-Alu is a representative of an Alu subclass numbering ∼400,000 copies, suggesting many genes may be regulated by such elements.
Measuring software usability

In recent years the increasingly competitive nature of the software industry has led to greater emphasis on software quality, causing software developing organizations to shift their attention towards usability, which is recognized as one of the key characteristics of software quality. The growing importance attached to software usability has resulted in a plethora of different usability conceptualisations that have led to considerable variation in testing methods throughout industry. These organizations, however, are struggling with usability testing due to the difficulties they face in choosing appropriate usability evaluation methods. This is in part due to the diversity of these testing methods and the increasingly distinctive types of software and software development life cycles. This paper will critically explore the commonly used standardized survey-based usability evaluation methods: SUMI (Software Usability Measurement Inventory), WAMMI (Website Analysis and Measurement Inventory) and TAM (Technology Acceptance Model). Additionally, a contrasting usability evaluation method ‘Think Aloud’ will be discussed, which is a laboratory based rather than field based usability test. The paper will then outline a possible route to ensuring organisations apply the right evaluation process for their individual development context. Finally, the paper will provide recommendations for future research areas, including the formal definition of usability concepts, existing usability evaluation methods and application to common software development lifecycles.
Association between hearing loss and Type 2 Diabetes Mellitus in elderly people in a newly developed society

This is a cross-sectional study. Hearing loss and its complications appear to be increasingly common in elderly people. Hearing impairment is becoming increasingly prevalent in old age and unfortunately many physicians do not view hearing loss as a significant problem and like the patient, often attribute it to normal aging. The aim of this study was to determine the prevalence of hearing loss and its association with type 2 diabetes mellitus (T2DM) in elderly people in a newly developed society. Ear Nose Throat (ENT) and Endocrinology outpatient clinics of the Hamad General and Ru-meilah Hospitals, Hamad Medical Corporation. All subjects aged more then 50 years who were visiting the Endocrinology and ENT outpa-tient clinics of the Hamad Medical Corporation with hearing difficulty were included in this study during the period from January 2003 to November 2006. During this study period, prevalence, hearing, audiological test, family history and medical problems associated with hearing impairment in old patients were recorded. The hearing loss was evaluated using two audiometers Grason Stadler GSI 61 and Madsen Orbiter 922. The prevalence of hearing impairment was higher among men (52.6%) than in women (49.5%). Also, hearing impairment was higher in Qataris (66.3%) than in non-Qataris (33.7%). 40.5% of the studied subjects were consanguineously married couples. Very se-vere (71- 90 dB) and profound (90 ? 120 dB) cases were found more in men (13.8% & 9.3%) than in women (10.2% & 8.2%). The associated risk factors were higher in men such as T2DM (37.8% & 25.5%), hypertension (37% vs 27%), retinopathy (31.7% vs 19.9%), Nephropathy (25.6% vs 17.9%), Neuropathy (22.8% vs 14.3%) than in women. There was a statistically significant relationship between both the genders in all the risk fac-tors. The study findings revealed that the prevalence of hearing loss was higher in elderly men than in women. Elderly individuals with hearing loss were likely to have T2DM and other risk factors like hypertension, retinopathy, nephropathy and neuropathy.
A novel approach for food intake detection using electroglottography

Many methods for monitoring diet and food intake rely on subjects self-reporting their daily intake. These methods are subjective, potentially inaccurate and need to be replaced by more accurate and objective methods. This paper presents a novel approach that uses an electroglottograph (EGG) device for an objective and automatic detection of food intake. Thirty subjects participated in a four-visit experiment involving the consumption of meals with self-selected content. Variations in the electrical impedance across the larynx caused by the passage of food during swallowing were captured by the EGG device. To compare performance of the proposed method with a well-established acoustical method, a throat microphone was used for monitoring swallowing sounds. Both signals were segmented into non-overlapping epochs of 30 s and processed to extract wavelet features. Subject-independent classifiers were trained, using artificial neural networks, to identify periods of food intake from the wavelet features. Results from leave-one-out cross validation showed an average per-epoch classification accuracy of 90.1% for the EGG-based method and 83.1% for the acoustic-based method, demonstrating the feasibility of using an EGG for food intake detection.
Role of Gluten Intake at the Time of Hepatitis B Virus Vaccination in the Immune Response of Celiac Patients

ABSTRACT Some reports have demonstrated an inadequate response to hepatitis B vaccination in patients affected by celiac disease. The aim of our study was to evaluate hepatitis B vaccination response in relation to gluten exposure status in patients with celiac disease. To measure the gluten exposure status at the time of vaccination, we considered three groups: group A (exposed to gluten), including patients vaccinated as 12-year-old adolescents (the celiac disease diagnosis was established after vaccination); group B (not exposed to gluten), including patients vaccinated as 12-year-old adolescents on a gluten-free diet at the time of vaccination; and group C (infants), including patients vaccinated at birth. The response of celiac patients to hepatitis B vaccination was compared to that of healthy subjects, i.e., those in the control group (group D). This study included 163 celiac patients (group A, 57 patients; group B, 46 patients; and group C, 60 patients) and 48 controls (group D). An inadequate response to hepatitis B immunization was present in 43.9% of patients in group A, 34.8% of patients in group B, 58.3% of patients in group C, and 8.3% of patients in group D (group A versus group D, P < 0.001; group B versus group D, P = 0.002; group C versus group D, P = 0.001) (no significant difference for group A versus group B and group A versus group C was evident). Our data suggest that gluten exposure does not influence the response to hepatitis B immunization and that the human leukocyte antigen probably plays the main immunological role in poor responses to hepatitis B-vaccinated celiac patients.
Sequence, transcriptional, and functional analyses of the valine (branched-chain amino acid) dehydrogenase gene of Streptomyces coelicolor

The gene encoding the valine (branched-chain amino acid) dehydrogenase (Vdh) from Streptomyces coelicolor has been characterized as follows. The vdh gene was identified by hybridization to a specific oligodeoxynucleotide that was synthesized on the basis of the N-terminal amino acid sequence of purified Vdh. Nucleotide sequence analysis predicts that the vdh gene contains a 364-amino-acid open reading frame that should produce a 38,305-M(r) protein. The deduced amino acid sequence of the Vdh protein is significantly similar to those of several other amino acid dehydrogenases, especially the leucine and phenylalanine dehydrogenases from Bacillus spp. The vdh gene is apparently transcribed from a single major transcriptional start point, separated by only 8 bp from the 5' end of a divergent transcript and located 63 bp upstream from the vdh translational start point. Mutants with a disrupted vdh gene have no detectable Vdh activity and have lost the ability to grow on valine, leucine, or isoleucine as the sole nitrogen source. This vdh mutation does not significantly affect growth or actinorhodin production in a minimal medium, yet the addition of 0.2% L-valine to the medium provokes approximately 32 and 80% increases in actinorhodin production in vdh+ and vdh strains, respectively.
The Role of Alpha Tocopheryl Succinate (α-TOS) as a Potential Anticancer Agent

In recent years, efforts to improve cancer therapy have focused on developing new anticancer agents, such as mitocans. These agents include vitamin E analogues and suppress cancer by inducing apoptosis by targeting mitochondria. Alpha tocopheryl succinate (α-TOS) is the most effective form of vitamin E analogues causing inhibition of proliferation and apoptosis of cancer cells. Both in vitro and in vivo studies have demonstrated that α-TOS selectively kills tumor cells with little or no effect on normal cells. Treatment with α-TOS shows great promise for future clinical applications, as it causes cell death, at least in part, by selectively inducing apoptosis by mitochondrial destabilization. This review presents an overview of perspectives on α-TOS and the potential uses of α-TOS in cancer treatment and other clinical applications.
Chromosome organization and chromatin modification: influence on genome function and evolution

Histone modifications of nucleosomes distinguish euchromatic from heterochromatic chromatin states, distinguish gene regulation in eukaryotes from that of prokaryotes, and appear to allow eukaryotes to focus recombination events on regions of highest gene concentrations. Four additional epigenetic mechanisms that regulate commitment of cell lineages to their differentiated states are involved in the inheritance of differentiated states, e.g., DNA methylation, RNA interference, gene repositioning between interphase compartments, and gene replication time. The number of additional mechanisms used increases with the taxon’s somatic complexity. The ability of siRNA transcribed from one locus to target, in trans, RNAi-associated nucleation of heterochromatin in distal, but complementary, loci seems central to orchestration of chromatin states along chromosomes. Most genes are inactive when heterochromatic. However, genes within β-heterochromatin actually require the heterochromatic state for their activity, a property that uniquely positions such genes as sources of siRNA to target heterochromatinization of both the source locus and distal loci. Vertebrate chromosomes are organized into permanent structures that, during S-phase, regulate simultaneous firing of replicon clusters. The late replicating clusters, seen as G-bands during metaphase and as meiotic chromomeres during meiosis, epitomize an ontological utilization of all five self-reinforcing epigenetic mechanisms to regulate the reversible chromatin state called facultative (conditional) heterochromatin. Alternating euchromatin/heterochromatin domains separated by band boundaries, and interphase repositioning of G-band genes during ontological commitment can impose constraints on both meiotic interactions and mammalian karyotype evolution.
Long-chain fatty acids inhibit human members of the aldo-keto reductase 1C subfamily

Four human hydroxysteroid dehydrogenases in the aldo-keto reductase (AKR) superfamily, AKR1C1-AKR1C4, are involved in the metabolism of steroids and other carbonyl compounds including drugs, and altered expression of AKRs (1C1, 1C2 and/or 1C3) is related to the pathogenesis of several extrahepatic cancers. Here, we report that unsaturated fatty acids (FAs) are potent competitive inhibitors of the AKR enzymes. The sensitivities to the FAs were different among the enzymes, especially between AKR1C1 and AKR1C2. The most potent inhibitors for AKR1C1, AKR1C2 and AKR1C4 were docosahexaenoic acid (Ki 0.77 µM), palmitoleic acid (Ki 0.41 µM) and linoleic acid (Ki 0.33 µM), respectively. AKR1C3 was the most sensitive to FA inhibition, showing low Ki values (0.23-0.29 µM) for oleic, linoleic, eicosapentaenoic and docosahexaenoic acids. Linoleic and oleic acids also inhibited AKR1C3-mediated metabolism of 9,10-phenanthrenequinone in colon DLD1 cells. Molecular docking and site-directed mutagenesis studies suggested upon FA binding to AKR1C1 and AKR1C3: (i) the carboxyl group of the FA binds to the oxyanion-binding site in the active site; (ii) the difference in FA sensitivity between AKR1C1 and AKR1C2 is due to their residue difference at position 54; (iii) Ser118, Phe306 and Phe311 of AKR1C3 are important for determining the inhibitory potency of FAs.
Improving the Performances of a Reverberation Chamber: a Real Case

In a previous measurement campaign [1] it was found that the reverberation chamber (RC) of CISAM EMC Department evidenced anomalous values of the Quality factor (Q) - too low to be "right" for a fully aluminum chamber - and moreover, after some use it became absolutely evident that it was too easy to improve - lowering it, of course - the value of the Lowest Usable Frequency (LUF) of this chamber. After some investigations on the chamber materials/components and on the assembly procedures, the authors developed the idea that this strange behavior had to be attributed to the tuners - being the original ones made with somehow absorbing material - and therefore they decided to replace them with new, all metal tuners. In this paper, the results of a calibration campaign on the reverberation chamber after tuner replacement are presented, as well as the results of an emission test on a standard reference source before and after the replacement. The calibration has been done in the frequency range 80 MHz ÷ 3 GHz, and the emission tests have been performed in the range 100 MHz to 1 GHz, which is exactly the frequency range of the reference radiator used to generate a standard spectrum. The comparison between the results obtained, under the same conditions, with the old and with the new tuners is presented, and the goodness of the assumptions demonstrated: with the new tuners the performances of the chamber have been considerably improved.
Salicylic Acid and Systemic Acquired Resistance Play a Role in Attenuating Crown Gall Disease Caused by Agrobacterium tumefaciens1[W][OA]

We investigated the effects of salicylic acid (SA) and systemic acquired resistance (SAR) on crown gall disease caused by Agrobacterium tumefaciens. Nicotiana benthamiana plants treated with SA showed decreased susceptibility to Agrobacterium infection. Exogenous application of SA to Agrobacterium cultures decreased its growth, virulence, and attachment to plant cells. Using Agrobacterium whole-genome microarrays, we characterized the direct effects of SA on bacterial gene expression and showed that SA inhibits induction of virulence (vir) genes and the repABC operon, and differentially regulates the expression of many other sets of genes. Using virus-induced gene silencing, we further demonstrate that plant genes involved in SA biosynthesis and signaling are important determinants for Agrobacterium infectivity on plants. Silencing of ICS (isochorismate synthase), NPR1 (nonexpresser of pathogenesis-related gene 1), and SABP2 (SA-binding protein 2) in N. benthamiana enhanced Agrobacterium infection. Moreover, plants treated with benzo-(1,2,3)-thiadiazole-7-carbothioic acid, a potent inducer of SAR, showed reduced disease symptoms. Our data suggest that SA and SAR both play a major role in retarding Agrobacterium infectivity.
Wonderful Mira

Since being named ‘wonderful’ in the seventeenth century for its peculiar brightness variability, Mira A has been the subject of extensive research and become the prototype for a whole class of ‘Mira’ variable stars. The primary star in a binary system, Mira A is reaching the end of its life and currently undergoing an extended period of enhanced mass loss. Recent observations have revealed a surrounding arc-like structure and a stream of material stretching 12 light years away in opposition to the arc. In this article, I review recent modelling of this cometary appearance as a bow shock with an accompanying tail of material ram pressure stripped from the head of the bow shock, place Mira in an evolutionary context, predict its future with reference to the similar star R Hya and planetary nebula Sh 2-188, and speculate some avenues of research both on Mira itself and on other ‘Mira-like’ stars with bow shocks and tails. I also discuss the implications of this discovery for our own star, the Sun.