Miracle-dz/UniFAR-FTUs huggingface dataset:
Genotype-phenotype correlation of patients with multiple endocrine neoplasia type 2 in Japan.

BACKGROUND Multiple endocrine neoplasia type 2 (MEN 2) is a hereditary syndrome characterized by medullary thyroid carcinoma (MTC), pheochromocytoma and hyperparathyroidism. MEN 2 is caused predominantly by germ-line mutations of the RET proto-oncogene. This study aimed to clarify the genotype-phenotype correlation in MEN 2 patients in Japan in order to modify the clinical management according to the genotype. METHODS Constitutive DNA of 64 MEN 2 patients (48 kindreds) were searched for mutations at exons 10, 11, 13, 14 and 16 of the RET proto-oncogene using polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP), direct sequencing and restriction enzyme digestion. The clinical characteristics of the patients were obtained from a previous nationwide questionnaire survey. RESULTS Overall, 62 (96.9%) out of 64 patients had a germ-line point mutation at the hot spots. MTC and pheochromocytoma occurred equally in every genotype except C630S. Specific genotype had a correlation between tumor size and age at the operation for MTC or extent of MTC, i.e. C618S developed late onset type of MTC as compared with that of C634R, C634Y and M918T. Small MTC in C634R may be less aggressive than those in C634Y and M918T. CONCLUSIONS DNA testing has good clinical implications for the management of patients with MEN 2 and the timing and operative procedures of thyroidectomy can be modified according to the genotype.
Maize SBP-box transcription factors unbranched2 and unbranched3 affect yield traits by regulating the rate of lateral primordia initiation

Significance Crop yields are dependent on the number of lateral primordia made by the inflorescence. In maize unbranched mutants, excess lateral primordia are made at the expense of the stem cells located in the center of the meristem. Ultimately, the unbranched mutant meristem lacks enough cells to regenerate and thus, terminates prematurely. This study shows that the duplicate transcription factors unbranched2 and unbranched3 function together to decrease the rate of lateral primordia initiation, thus giving the stem cells of the meristem enough time to regenerate. Variants of the unbranched3 gene affect different aspects of lateral primordia initiation that control crop yield. The separation of male and female flowers in maize provides the potential for independent regulation of traits that affect crop productivity. For example, tassel branch number controls pollen abundance and length of shedding time, whereas ear row number directly affects kernel yield. Mutations in duplicate SBP-box transcription factor genes unbranched2 (ub2) and ub3 affect both of these yield traits. Double mutants display a decrease in tassel branch number and an increase in ear row number, both of which are enhanced by loss of a related gene called tasselsheath4 (tsh4). Furthermore, triple mutants have more tillers and leaves—phenotypes seen in Corngrass1 mutants that result from widespread repression of SBP-box genes. Immunolocalization of UB2 and UB3 proteins revealed accumulation throughout the meristem but absence from the central domain of the meristem where cells regenerate. Thus, ub2, ub3, and tsh4 function as redundant factors that limit the rate of cell differentiation to the lateral domains of meristems. When these genes are mutated, cells are allocated to lateral primordia at a higher rate, causing a net loss of cells from the central domain and premature termination of the inflorescence. The ub3 locus is tightly linked to quantitative trait loci (QTL) for ear row number and tassel branch number in both the nested association mapping (NAM) and intermated B73 by Mo17 (IBM) populations of maize recombinant inbreds, indicating that this gene may be agronomically important. Analysis of ear and tassel QTL across biparental families suggests that multiple mutations in ub3 independently regulate male and female inflorescence development.
THE METABOLISM OF TUMORS IN THE BODY

In this contribution we discuss the question of whether tumor cells in living animals can be killed off through lack of energy, and the related question of how the tumors are supplied with oxygen and glucose in the body. We assume it is understood that tumor cells obtain the energy required for their existence in two ways: by respiration and by fermentation. In respiration they burn organic materials to carbon dioxide and water; in fermentation they split glucose to lactic acid. All tumors so far tested behave fundamentally alike. There is no essential difference between the cancer cells of transplanted rat tumors and spontaneous tumors, sarcoma and carcinoma cells, and the tar carcinoma, and Rous sarcoma produced by filtrate. The fermentation of tumors was first found with cut pieces of tumor in vitro. I C. and G. Cori 2 demonstrated it in living animals as well. They determined the glucose and lactic acid in the axillary veins of hens having in one wing a Rous sarcoma, and found in 100 cc. of blood 23 mg. less glucose and 16 rag. more lactic acid on the tumor side than on the normal side. A corresponding experiment with a human fore-arm tumor showed in 100 cc. of blood 12 rag. less glucose and 9 rag. more lactic acid on the tumor side. In experiments on the nourishment of tumors through the blood stream, we, like Cori, determined the glucose and lactic acid in tumor veins. Our procedure differed from Cori's in that we compared tumor veins and arteries, not tumor veins and corresponding normal veins. Our differences were greater than Cori's because we went closer to
Diagnosing Cerebral Visual Impairment in Children with Good Visual Acuity

Purpose: To identify elements that could facilitate the diagnosis of cerebral visual impairment (CVI) in children with good visual acuity in the general ophthalmic clinic. Methods: We retrospectively investigated the clinical characteristics of 30 children with good visual acuity and CVI and compared them with those of 23 children who were referred with a suspicion of CVI, but proved to have a different diagnosis. Clinical characteristics included medical history, MRI findings, visual acuity, crowding ratio (CR), visual field assessment, and the results of ophthalmologic and orthoptic examination. We also evaluated the additional value of a short CVI questionnaire. Results: Eighty-three percent of the children with an abnormal medical history (mainly prematurity and perinatal hypoxia) had CVI, in contrast with none of the children with a normal medical history. Cerebral palsy, visual field defects, and partial optic atrophy only occurred in the CVI group. 41% of the children with CVI had a CR ≥2.0, which may be related to dorsal stream dysfunction. All children with CVI, but also 91% of the children without CVI gave ≥3 affirmative answers on the CVI questionnaire. Conclusion: An abnormal pre- or perinatal medical history is the most important risk factor for CVI in children, and therefore in deciding which children should be referred for further multidisciplinary assessment. Additional symptoms of cerebral damage, i.e., cerebral palsy, visual field defects, partial optic atrophy, and a CR ≥2 may support the diagnosis. CVI questionnaires should not be used for screening purposes as they yield too many false positives.
Example-based learning: Effects of different types of examples on student performance, cognitive load and self-efficacy in a statistical learning task

ABSTRACT Previous research has indicated the disconnect between example-based research focusing on worked examples (WEs) and that focusing on modeling examples. The purpose of this study was to examine and compare the effect of four different types of examples from the two separate lines of research, including standard WEs, erroneous WEs, expert (masterly) modeling examples, and peer (coping) modeling examples, on student performance (knowledge retention, near transfer, and far transfer), cognitive load, and self-efficacy. One hundred and sixteen students participated in the study by undergoing computer-based instruction in one of the four versions differing in how examples were provided. The results showed that, overall, expert modeling examples were most effective in promoting knowledge retention, near transfer, and far transfer, while peer modeling examples were shown to be superior in fostering self-efficacy among the four different types of examples.
Experiences of elderly patients regarding independent community living after discharge from hospital: a longitudinal study.

OBJECTIVE To describe the reported experiences of elderly patients regarding their transition from an acute hospital to independent community living. DESIGN Observational longitudinal study based on semi-structured interviews conducted monthly for 6 months following discharge from hospital. SETTING Four South Australian acute hospitals. Patients. One hundred elderly patients who faced a long-term change in health status and/or in their ability to manage practical aspects of daily living. MAIN OUTCOME MEASURES Experiences in managing change in health status, social circumstances and independent community living. RESULTS Few patients believed that discharge plans made in hospital had assisted their return to independent community living. Discharge planning addressed mainly formal health services rather than practical aspects of daily living. Many patients implemented innovative solutions when formal services were unavailable or inadequate. Pain, tiredness, loss of mobility, and grief over loss of previous abilities were frequent, long lasting sequelae to illness, and few discharge plans prepared patients to deal with this. CONCLUSIONS Elderly patients who have left hospital to face a permanent change in health status often regret that they have not been better prepared for what lies ahead in terms of more specific information about their condition, linked with practical discharge plans that prepare them for their period of convalescence. We suggest that the underlying problem is a disjunction between the multiple systems involved in hospital discharge planning, primary medical care, disability-oriented community health services, and informal community services.
30 years of campylobacters: biochemical characteristics and a biotyping proposal for Campylobacter jejuni

Several biochemical test systems were studied for their potential usefulness for the examination of strains of Campylobacter species. Most (81%) of the C. jejuni strains hydrolyzed sodium hippurate, but strains of C. fetus, C. sputorum, and C. fecalis did not. Some (46%) of the C. jejuni strains and all of the C. sputorum subsp. sputorum, C. sputorum subsp. bubulus, and C. fecalis strains hydrolyzed DNA, but the C. fetus and C. sputorum subsp. mucosalis strains did not. Strains of all species of Campylobacter grew on charcoal-yeast extract agar, but 47% of the C. jejuni strains did not. Alkaline phosphatase activity was recorded for some strains of C. jejuni, but all other species were negative for this activity. Aryl sulfatase activity was detected in 7% of the C. jejuni, 15% of the C. fetus subsp. fetus, and all of the C. sputorum subsp. sputorum, C. sputorum subsp. bubulus, and C. fecalis strains, but it was not detected in the C. fetus subsp. venerealis and C. sputorum subsp. mucosalis strains. Most (93%) of the C. jejuni but none of the other Campylobacter strains contained lactobacillic acid when examined for cellular fatty acids. On the basis of results from three of these tests (hippurate hydrolysis, DNA hydrolysis, and growth on charcoal-yeast extract agar), clinical strains of C. jejuni were placed in eight biotypes.
Modelling services to meet the palliative care needs of chronic heart failure patients and their families: current practice in the UK

Objective : To describe current provision of specialist palliative care for chronic heart failure (CHF) patients, and explore challenges, referral criteria and recommendations to inform service development. Method : Semi-structured qualitative telephone survey of key professionals involved in CHF palliative care in the UK. Results : Twenty telephone interviews were conducted with staff from 17 services comprising three main types: hospital-based (n = 7), community-based (n = 6) and hospice-based (n = 4). The main recommendations made were to establish mechanisms for joint working between palliative care and cardiology; to ensure that stakeholders are involved from the outset of service planning; and to involve community heart failure nurses in service provision. Referral guidelines were collected from four services, covering diagnostic, symptomatological, psychosocial and team-related criteria. Conclusions : Information regarding existing services' challenges, recommendations and referral systems is essential when designing a new service, maximising feasibility and acceptability. This study design is of particular value when descriptions and evaluations of service models are lacking in the literature. The survey gives much-needed depth and detail to the types of services currently providing palliative care to CHF patients across the UK. Palliative Medicine 2007; 21 : 385—390
Exploring mechanisms responsible for tidal modulation in flow of the Filchner–Ronne Ice Shelf

Abstract. An extensive network of GPS sites on the Filchner–Ronne Ice Shelf and adjoining ice streams shows strong tidal modulation of horizontal ice flow at a range of frequencies. A particularly strong (horizontal) response is found at the fortnightly (Msf) frequency. Since this tidal constituent is absent in the (vertical) tidal forcing, this observation implies the action of some non-linear mechanism. Another striking aspect is the strong amplitude of the flow perturbation, causing a periodic reversal in the direction of ice shelf flow in some areas and a 10 %–20 % change in speed at grounding lines. No model has yet been able to reproduce the quantitative aspects of the observed tidal modulation across the entire Filchner–Ronne Ice Shelf. The cause of the tidal ice flow response has, therefore, remained an enigma, indicating a serious limitation in our current understanding of the mechanics of large-scale ice flow. A further limitation of previous studies is that they have all focused on isolated regions and interactions between different areas have, therefore, not been fully accounted for. Here, we conduct the first large-scale ice flow modelling study to explore these processes using a viscoelastic rheology and realistic geometry of the entire Filchner–Ronne Ice Shelf, where the best observations of tidal response are available. We evaluate all relevant mechanisms that have hitherto been put forward to explain how tides might affect ice shelf flow and compare our results with observational data. We conclude that, while some are able to generate the correct general qualitative aspects of the tidally induced perturbations in ice flow, most of these mechanisms must be ruled out as being the primary cause of the observed long-period response. We find that only tidally induced lateral migration of grounding lines can generate a sufficiently strong long-period Msf response on the ice shelf to match observations. Furthermore, we show that the observed horizontal short-period semidiurnal tidal motion, causing twice-daily flow reversals at the ice front, can be generated through a purely elastic response to basin-wide tidal perturbations in the ice shelf slope. This model also allows us to quantify the effect of tides on mean ice flow and we find that the Filchner–Ronne Ice Shelf flows, on average, ∼ 21 % faster than it would in the absence of large ocean tides.
Billiard complexity in the hypercube

We consider the billiard map in the hypercube of $\mathbb{R}^d$. We obtain a language by coding the billiard map by the faces of the hypercube. We investigate the complexity function of this language. We prove that $n^{3d-3}$ is the order of magnitude of the complexity.
Treatment Approaches for Management of Poisonings in India

Background: Poisoning is a common medical emergency needing prompt medical interventions. The study focuses on pattern of toxic agents, drug utilization, management and outcome in poisonings reported. Methods: The cross sectional study was carried out on patients admitted to two urban hospitals in Pune, Maharashtra from January 2014 March 2016. Results: Total 1078 cases of poisoning were reported with male (57.1%) predominance. The cases reported ranged from 8 months to 72 years old in age with a mean (± SD) 37.8 ± 27.3. Intentional poisoning was more common (53%). Route of exposure was mostly Ingestion (72.5%) followed by Bite/ Sting (26.4%), Inhalational (0.8%), Injection (0.1%) and Eye (0.1%). Household and agricultural agents (56.4%) were associated with most poisoning followed by Animal Bites and Stings (26.4%). The mortality reported was 9.7%. The management included Supportive treatment, Antidotes, and Enhanced Elimination Techniques. Supportive treatment was mainly with Gastro protective (94.3%) and Anti-Microbial (77.9%) agents. The antidote was used in 70.9% cases and mostly included Anti-Snake Venom (24.4%) followed by Atropine (21%) and Pralidoxime (18.1%). Enhanced Elimination Techniques included Gastric Lavage (76.3%), Nasogastric Aspiration (7.2%), Hemodialysis (0.1%), Activated Charcoal (4.5%) and Eye wash (0.1%). Conclusion: The treatment approaches were based on parameters such as route of exposure, Toxic agent involved and age of the patient. The pharmacist can play a vital role in the recommendation of the rational management plan in Poisonings.
Burnout Syndrome in the Helping Professions

Burnout can be defined as a long-term reaction to occupational stress which involves, particularly, the helping professions. The main aim of this study was the assessment of burnout in a sample of professional and voluntary health care workers and comparison of the two samples on scores from the Maslach Burnout Inventory. Analysis suggests a significant difference in mean scores for Emotional Exhaustion of volunteers vs professional workers. Some evidence has supported the hypothesis of a fourth dimension, called Behavioral Exhaustion, in the burnout syndrome.
Increased mortality associated with the early coagulopathy of trauma in combat casualties.

BACKGROUND Recent civilian studies have documented a relationship between increased mortality and the presence of an early coagulopathy of trauma diagnosed in the emergency department (ED). We hypothesized that acute coagulopathy (international normalized ratio >/=1.5) in combat casualties was associated with increased injury severity and mortality as is seen in civilian trauma patients. METHODS A retrospective study of combat casualties who received a blood transfusion at a single combat support hospital between September 2003 and December 2004 was performed. Coagulation status, pH, base deficit, and temperature were recorded at arrival to the ED. These were analyzed by Injury Severity Score (ISS), associated injury patterns, and mortality. RESULTS A total of 3,287 patients were treated at the combat support hospital during the study period. Of these, 391 patients were transfused and primarily admitted, thus meeting the study criteria, 347 had coagulation data, and 92% had a penetrating mechanism. The prevalence of acute coagulopathy in transfused casualties measured with point-of-care devices at arrival in the ED was 38%. Mortality in those who were coagulopathic at arrival to the ED was 24% (32/133) versus 4% (8/214) in those not presenting with coagulopathy (p < 0.001). The prevalence of mortality by coagulopathy increased as ISS increased. Coagulopathy and acidosis were associated with mortality, odds ratio (OR), 5.38 [95% confidence interval (CI), 1.55-11.37] and 6.9 (95% CI, 2.1-19.5), respectively. Temperature did not affect outcomes (OR, 1.1; 95% CI, 0.4-2.6). CONCLUSIONS The early coagulopathy of trauma was rapidly diagnosed in the ED and present in more than one-third of combat casualties who received a transfusion, similar to the incidence found in civilian trauma patients. Coagulopathy, independent of hypothermia but strongly correlated with acidosis and ISS, was associated with mortality in combat casualties, similar to that found in civilian trauma patients. Early diagnosis and treatment of acute traumatic coagulopathy with new resuscitation paradigms may improve outcomes.
IgG and IgM Antibody Reactivity to Antigens of Treponema pallid um after Treatment of Syphilis

The persistence or loss of IgG and IgM antibody specificities for individual polypeptides of Treponema pallidum after therapy for syphilis was examined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and by the Western blot technique. Both IgG and IgM antibodies to as many as 12 treponemal antigens, including a major 47-kdalton molecule, were evident in plasma from patients with untreated primary syphilis. IgM reactivity declined rapidly and uniformly after therapy, whereas IgG persisted despite some diminution in intensity of staining. Faint-to-moderate IgM and strong IgG antibody reactivities to at least 22 treponemal antigens (12-85 kdaltons) were identified in plasma from patients with untreated secondary and early latent syphilis. Again, IgG antibody declined slightly in staining intensity after treatment but continued to show reactivity against all molecules detected initially. IgM antibody reactivity declined more rapidly and was lost entirely against some determinants, including the 14- and 12-kdalton molecules. Immunofluorescence titers of IgG and IgM antibodies to T. pallidum in sera from these patients generally correlated with results of Western blot analysis. Antibody to the 12-, 14-, and 47-kdalton molecules of T. pallidum may have potential diagnostic applications.
Use of CC Traps with Different Trap Base Colors for Silverleaf Whiteflies (Homoptera: Aleyrodidae), Thrips (Thysanoptera: Thripidae), and Leafhoppers (Homoptera: Cicadellidae)

Abstract During 1996, 1997, and 1999, studies were conducted in cotton, sugar beets, alfalfa, yardlong bean, and peanut fields to compare insect catches in CC traps equipped with different trap base colors. The studies were conducted in southwestern United States, China, and India. The nine colors, white, rum, red, yellow, lime green, spring green, woodland green (dark green), true blue, and black, varied in spectral reflectance in the visible (400–700 nm) and near-infrared (700–1050 nm) portions of spectrum. Lime green, yellow, and spring green were the three most attractive trap base colors for silverleaf whitefly, Bemisia argentifolii Bellows & Perring, and leafhopper, Empoasca spp. adults. The three trap base colors were moderately high in the green, yellow, and orange spectral regions (490–600 nm), resembling the spectral reflectance curve of the abaxial (underleaf) surfaces of green cotton leaves. True blue and white were the most attractive trap base colors for western flower thrips, Frankliniella occidentalis (Pergande), adults. The true blue and white trap bases were moderately high in the blue spectral region (400–480 nm).
‘Fertility’ and the Carnival 1: Symbolic Effectiveness, Emic Beliefs, and the Re-enchantment of Europe

Abstract This article examines European festive culture through the lens of two ethnographic case studies of carnivals, conducted in Italy and the Czech Republic, respectively. The article considers the general problem of studying festivals in Europe today, and then focuses on the emic beliefs related to the ‘ritual magical’ acts of these two carnivals, their social relevance, their effectiveness, and the meanings and functions to which they are bound today. I argue that these acts constitute empirical evidence that supports theories about the ‘re-enchantment’ of Europe in post-modern times. This article is the first part of a broader study divided into two parts.