Miracle-dz/UniFAR-FTUs huggingface dataset:
Nerve Growth Factor in Glia and Inflammatory Cells of the Injured Rat Spinal Cord

Abstract: Nerve growth factor (NGF) is crucial for the development of sympathetic and small‐diameter sensory neurons and for maintenance of their mature phenotype. Its role in generating neuronal pathophysiology is less well understood. After spinal cord injury, central processes of primary afferent fibers sprout into the dorsal horn, contributing to the development of autonomic dysfunctions and pain. NGF may promote these states as it stimulates sprouting of small‐diameter afferent fibers and its concentration in the spinal cord increases after cord injury. The cells responsible for this increase must be identified to develop a strategy to prevent the afferent sprouting. Using immunocytochemistry, we identified cells containing NGF in spinal cord sections from intact rats and from rats 1 and 2 weeks after high thoracic cord transection. In intact rats, this neurotrophin was present in a few ramified microglia and in putative Schwann cells in the dorsal root. Within and close to the lesion of cord‐injured rats, NGF was in many activated, ramified microglia, in a subset of astrocytes, and in small, round cells that were neither glia nor macrophages. NGF‐immunore‐active putative Schwann cells were prevalent throughout the thoracolumbar cord in the dorsal roots and the dorsal root entry zones. Oligodendrocytes were never immunoreactive for this protein. Therapeutic strategies targeting spinal cord cells that produce NGF may prevent primary afferent sprouting and resulting clinical disorders after cord injury.
Relational governance as an interorganizational strategy: An empirical test of the role of trust in economic exchange

We develop a model of relational governance as a specific form of interorganizational strategy that is distinct from the traditional modes of markets and hierarchies. We conceptualize this form of strategy in terms of structural and processual dimensions and derive a model of its determinants through arguments drawn from transaction cost economics and the sociological exchange literature. Hierarchical regression modeling is employed to test the theoretical model on data collected from a sample of 329 independent insurance agencies. We include the relational variable of trust and demonstrate that the combined model explains relational governance better than a model with the traditional determinants of governance form alone. Further, we observe that governance structure and process are related and discuss implications of the dynamic link between them. Directions for extensions are developed for strategic management research and practice.
MIB‐1 and PCNA immunostaining as a diagnostic adjunct to cervical Pap smear

The present study was done to determine the role of MIB‐1 (Molecular Immunology Borstel) and proliferating cell nuclear antigen (PCNA) proliferative index as a diagnostic adjunct to cervical Papanicolaou (Pap) smear for the identification of ascending grades of cervical intraepithelial neoplasia (CIN) developing into cancer in the human uterine cervix. A total of 49 adequate Pap smears with consensus diagnosis were destained for immunocytochemical staining (MIB‐1 and PC10). Staining was done by streptavidin‐biotin method after antigen retrieval. MIB‐1 and PC10 labeling index (LI) were calculated in each case and divided into three groups, i.e., <10%, 10–20%, and >20%, respectively. Statistical analysis was done by using the SPSS 10.0 package. The comparisons were made using analysis of variance (ANOVA) and independent sample t‐test. Bivariate and Pearson's correlation coefficient were used to obtain correlations between different groups. Out of 49 cases, 40 cases (81.6%) showed positive immunostaining with MIB‐1 and PCNA. Proliferative LI of MIB‐1 and PCNA increased with the ascending grades of CIN lesions to carcinoma. The highest proliferative index (mean ± SD) for PCNA and MIB‐1 were observed for the carcinoma group (PCNA LI, 39.200 ± 1.6865; MIB‐1LI, 35.300 ± 1.8886). A significant positive correlation between ascending grades of squamous intraepithelial lesion (SIL) and labeling indices of markers (r = 0.87 for MIB‐1 and r = 0.88 for PCNA) suggests that MIB‐1/PCNA proliferative markers can be used as an adjunct to cytomorphological interpretation of conventional cervical Pap smear. Diagn. Cytopathol. 2005;33:15–19. © 2005 Wiley‐Liss, Inc.
Vegetable consumption among Scottish children: a review of the determinants and proposed strategies to overcome low consumption

Discusses the factors shaping Scottish children’s perceptions of vegetables as a means of explaining their low vegetable consumption. Examines the impact that sensory factors, the child’s family and eating experiences, and environmental factors (i.e. socio‐economic factors/income, culture, eating patterns and advertising) have on children’s vegetable consumption. Additionally, makes suggestions for strategies to overcome some of these factors which affect children’s low consumption of vegetables.
Service Product Development for Sustainable Competitive Advantage; The Use of the Sources - Position - Performance Model

The results of research into the competitiveness of service firms using the Sources – Performance – Position (SPP) model suggests that a culture of innovation is more important to success than the actual innovation process. Top innovators are more market-oriented, invest more in branding and take more risks. In order to sustain their sources of competitive advantage, these firms also tend to reinvest profits in personnel skills training. This paper reports on the findings of a two stage study survey and follow-up interviews with senior managers of a broad array of service providers, and discusses the implications for services innovation practices and for future research.
The Fortune at the Bottom of the Pyramid

The world's most exciting, fastest-growing new market? It's where you least expect it: at the bottom of the pyramid. Collectively, the world's billions of poor people have immense entrepreneurial capabilities and buying power. You can learn how to serve them and help millions of the world's poorest people escape poverty.It is being done-profitably. Whether you're a business leader or an anti-poverty activist, business guru Prahalad shows why you can't afford to ignore "Bottom of the Pyramid" (BOP) markets.In the book and accompanying CD videos, Prahalad presents.Why what you know about BOP markets is wrong A world of surprises-from spending patterns to distribution and marketingUnlocking the "poverty penalty"The most enduring contributions your company can make Delivering dignity, empowerment, and choice-not just productsCorporations and BOP entrepreneurs Profiting together from an inclusive new capitalism "C. K. Prahalad argues that companies must revolutionize how they dobusiness in developing countries if both sides of that economic equation areto prosper. Drawing on a wealth of case studies, his compelling new bookoffers an intriguing blueprint for how to fight poverty with profitability. " Bill Gates, Chairman and Chief Software Architect,Microsoft "The Bottom of the Pyramid belongs at the top of the reading list forbusiness people, academics, and experts pursuing the elusive goal ofsustainable growth in the developing world. C. K. Prahalad writes withuncommon insight about consumer needs in poor societies andopportunities for the private sector to serve important public purposes whileenhancing its own bottom line. If you are looking for fresh thinking aboutemerging markets, your search is ended. This is the book for you. " Madeleine K. Albright, Former U.S. Secretary of State "Prahalad challenges readers to re-evaluate their pre-conceived notionsabout the commercial opportunities in serving the relatively poor nations ofthe world. The Bottom of the Pyramid highlights the way to commercialsuccess and societal improvement--but only if the developed worldreconceives the way it delivers products and services to the developingworld. " Christopher Rodrigues, CEO, Visa International "An important and insightful work showing persuasively how the privatesector can be put at the center of development, not just as a rhetoricalflourish but as a real engine of jobs and services for the poor. " Mark Malloch Brown, Administrator, United Nations Development Programme
The host relationships of Ixodes hexagonus Leach in Britain

On the available data from south Wales and southeast England, the tick Ixodes hexagonus Leach has spring and autumn peaks of activity on hedgehogs, stoats and weasels. One or more stages of this tick have been recorded on fifteen mammalian hosts. All stages have been collected from hedgehogs, stoats, foxes, polecats and ferrets. The weasel is probably the smallest habitual host. No specimens of I. hexagonus have been found on birds. Man is an ‘accidental’ host and records of this tick on man in the London area are given. From the present information it seems that ill-effects following the bite of this parasite are rare. In built-up areas the probable sources of infestation are dogs, cats and hedgehogs. Air-raid shelters and similar constructions which have harboured these hosts at one time or another may provide a centre of infestation of man. Our observations indicate that the number of ticks in most hedgehogs' nests is not large. Nothing is known of the tick population in the habitats of other hosts. It is suggested tentatively that the ticks may drop off hedgehogs away from the nest and that after further development (i.e. hatching of eggs and metamorphoses of later stages) they are picked up by such animals as foxes, stoats, weasels. The records of this tick in Britain are summarized and they indicate that I. hexagonus is a southern species.
Different Membrane Anchoring Positions of Tryptophan and Lysine in Synthetic Transmembrane α-Helical Peptides*

Specific interactions of membrane proteins with the membrane interfacial region potentially define protein position with respect to the lipid environment. We investigated the proposed roles of tryptophan and lysine side chains as “anchoring” residues of transmembrane proteins. Model systems were employed, consisting of phosphatidylcholine lipids and hydrophobic α-helical peptides, flanked either by tryptophans or lysines. Peptides were incorporated in bilayers of different thickness, and effects on lipid structure were analyzed. Induction of nonbilayer phases and also increases in bilayer thickness were observed that could be explained by a tendency of Trp as well as Lys residues to maintain interactions with the interfacial region. However, effects of the two peptides were remarkably different, indicating affinities of Trp and Lys for different sites at the interface. Our data support a model in which the Trp side chain has a specific affinity for a well defined site near the lipid carbonyl region, while the lysine side chain prefers to be located closer to the aqueous phase, near the lipid phosphate group. The information obtained in this study may further our understanding of the architecture of transmembrane proteins and may prove useful for refining prediction methods for transmembrane segments.
Determinants of Opening-Forwarding E-Mail Messages

E-mail viral marketing is today perceived as a form of electronic word-of-mouth (eWOM) advertising in which firms use provocative content to motivate unpaid peer-to-peer communication of persuasive messages from identified sponsors. However, the success of this practice depends on a range of factors, including those we explore and refer to in the present research as individuals' opening and forwarding of messages. From the theoretical perspectives of the social capital theory and the processing-information approach in a persuasive context, we explore how individuals' structural, relational, and cognitive social capital; the message characteristics; individuals' motivations; and the situational context impact the intention to open and forward viral messages. The empirical analysis of the structural model provides new and relevant theoretical and business implications for advertising.
Corporate acquisition strategies and economic performance

This research investigates the conceptual argument that acquisitions which are related in product/market or technological terms create higher value than unrelated acquisitions. Related acquisitions are found to have greater total dollar gains than unrelated acquisitions. Acquired firms in related acquisitions have substantially higher gains than acquired firms in unrelated acquisitions. These findings indicate that related target firms benefit more from acquisition than unrelated target firms. Implications of these findings for managers are discussed.
Oral health condition of French elderly and risk of dementia: a longitudinal cohort study.

OBJECTIVES Oral condition could be associated with cognitive impairment, but this is not yet well documented. We therefore hypothesized that people with poor oral condition would be more at risk to develop dementia. The objective of this study thus was to describe the oral condition of French community-dwelling elderly persons and to assess its relationship with the occurrence of dementia. METHODS Oral examination was conducted on a sample of individuals aged 66-80 years followed-up prospectively for screening of dementia over 15 years in Gironde, France. Univariate and multivariate analyses of the risk of dementia were performed using a Cox proportional hazard model with delayed entry. RESULTS Data from 405 individuals were analyzed; 45.4% men; median age at baseline: 70 years [interquartile range (IQR): 68-75]. The median number of decayed, missing, and filled teeth was 18 (IQR: 13-24) and was higher in women (median: 20 versus 17, P = 0.004) and in persons with lower school level (median: 21 versus 17, P = 0.003). Among 348 persons with sextant eligible for periodontal assessment, 2/3 required periodontal care: 5.2% had bleeding observed, 44.8% calculus, 17.8% 4-5 mm pockets, and 2.9%≥ 6 mm pockets. The incidence of dementia during a median follow-up of 10 years (IQR: 6.5-13.7) was 19 per 1000 person-years. The adjusted hazard ratio for a number of missing teeth ≥ 11 (median) on the risk of dementia was 1.13 (95% confidence interval, CI = [0.60-2.12]) in people with higher education (n = 312) and 0.30 (CI = 0.11-0.79) in persons with lower school level (n = 93) (P for modification effect = 0.0002). CONCLUSIONS Having eleven or more missing teeth seemed to be associated with a lower risk of dementia in people with lower education possibly owing to the suppression of source of chronic inflammation.
Plexogenic arteriopathy in broiler lungs: Evaluation of line, age, and sex influences.

Plexiform lesions form in the terminal pulmonary arterioles of human patients suffering from prolonged pulmonary arterial hypertension. Plexiform lesions also develop in broiler lungs, but lesion incidences are not strongly correlated with sustained pulmonary hypertension as reflected by right to total ventricular weight (RVTV) ratios. The present study was conducted to assess plexiform lesion incidences in broiler lines that have been divergently selected for susceptibility or resistance to pulmonary hypertension. Broilers from susceptible (SUS) and resistant (RES) lines were reared together and only clinically healthy (nonascitic, noncyanotic) individuals were evaluated to minimize potential line differences in cardiopulmonary hemodynamics. The objective was to determine if an innate genetic predisposition for plexogenic arteriopathy would be exposed in SUS broilers when compared with RES broilers in the absence of extreme differences in cardiopulmonary hemodynamics. Broilers up to 12 wk age from the SUS and RES lines had essentially equivalent BW, indices of cardiopulmonary function (left ventricle + septum weight, total ventricle weight, and RVTV ratios), and lung volumes within a sex. Average RVTV ratios for broilers from both lines were indicative of normal pulmonary arterial pressures at all ages sampled. Nevertheless, plexiform lesions were detected in SUS and RES broiler lungs immediately posthatch and thereafter at all ages sampled. Lesion incidences were consistently low and did not differ between the lines within any of the sampling ages. This evidence demonstrates that plexiform lesions develop extremely rapidly in broiler chicks, apparently without the prerequisite for vascular stress caused by severe, prolonged pulmonary arterial hypertension. No innate genetic predisposition for complex vascular lesion development appeared to exist in the SUS line when compared with the RES line.
Analgesic and Hemodynamic Effects of Epidural Clonidine, Clonidine/Morphine, and Morphine After Pancreatic Surgery--A Double-Blind Study

This study characterizes analgesia and hemodynamics after epidural clonidine 8 micro gram/kg (Group C) or clonidine 4 micro gram/kg + morphine 2 mg (Group CM) in comparison to epidural morphine 50 micro gram/kg (Group M). Forty-five patients scheduled for pancreatectomy in combined general/epidural anesthesia were studied. The study drugs were administered 75 min postoperatively and for 10 h pain intensity (visual analog scale [VAS]), heart rate (HR), mean arterial pressure (MAP), and cardiac output (CO) were measured; filling pressures were kept >5 mm Hg. Adequate analgesia could be achieved within 1 h in all patients of Groups C and CM, but only in six patients of Group M (P < 0.001). Quality of analgesia was comparable in all groups (VAS reduction 82% +/- 20%, mean +/- SD) but duration of analgesic action was longer in Groups CM (586 +/- 217 min) and M (775 +/- 378 min) compared to Group C (336 +/- 119 min) (P < 0.001). In Group M, no hemodynamic alterations occurred. In Groups C and CM, HR, CO, and MAP were reduced significantly compared to baseline within the first 15-90 min, while stroke volume and systemic vascular resistance remained stable. We conclude, that hemodynamic alteration after epidural clonidine under conditions of stable filling pressures is caused mainly by a decrease in HR. It is not an effect of analgesia but of the intrinsic antihypertensive action of clonidine. (Anesth Analg 1995;80:869-74)
Influence of corporate responsibility on financial return in forest plantations: case studies from South America, South East Asia and Africa

Investments in planted forests in emerging markets are increasing and investors are looking for Sustainable and Responsible Investments (SRI) to integrate Environmental, Social And Governance (ESG) into the investment process. This study is presenting a first attempt to develop a framework to evaluate the ESG performance of investments in planted forests and to identify relations between the use of SRI tools and the financial performance of investments in planted forests. The analysis of 121 investments in planted forests allowed the identification of 339 organizations and 50 SRI tools (e.g.: management and investment standards, investment rating) operating with investments in planted forests in emerging markets. The analysis of the 50 SRI tools resulted in the definition of a ESG Reference Document including 155 issues. These issues were organized into an ESG Risk Assessment and have been tested in 12 case studies evenly distributed between Uganda, Cambodia and Vietnam. The results suggest that the most common instruments are management standards (e.g.: FSC), bank investment policies (e.g.: ABN AMRO Forest and Plantation Policy) and investment rating systems (e.g.: FairForest). The majority of the SRI tools have a broad sectoral approach and are managed by business organizations. Investors are using more than 30 SRI tools but these are characterized by a low level of control such as signature and/or participation or at the most a conformity declaration. On the contrary plantation companies are using less instruments but with top level of control such conformity assessment and certification. Aspects related to “Legal and Institutional framework” and “Environment” are the most represented inside SRI tools. On the contrary aspects such as “Minimum percentage of protected areas”, “Poverty reduction” and “Prevention of encroachment” are not only the less frequent issues but also the less controlled issues by SRI tools. The Gold Standard and the Forest Stewardship Council are the SRI tools with the highest performance among the 50 SRI tools analysed. The ESG Risk Assessment allows to identify the most important 25 issues and reveals that SRI tools are focusing on issues that on-the-ground are not the major risk sources. This is the case of “Third party certification” and “High Conservation Value Forests” (HCVFs). Few exemptions where SRI tools are properly identifying the major risks are “Tenure rights”, “Health and safety of workers” and “Social impact assessment”. Climate change impacts, long term financial sustainability, poverty reduction and encroachment are ranked as the most dangerous sources of risk across the 12 case studies. SRI tools are positively influencing the risk mitigation, accounting for a percentage of risk mitigation that ranges from 34.31 till 60.63%. FSC certification was often reported by projects’ stakeholders as a key instrument to mitigate risk of investments in planted forests.
Three-Dimensional Numerical Simulation of a 30-GHz Gyrotron Resonator With an Explicit High-Order Discontinuous-Galerkin-Based Parallel Particle-In-Cell Method

Fast design codes for the simulation of the particle-field interaction in the interior of gyrotron resonators are available. They procure their rapidity by making strong physical simplifications and approximations, which are not known to be valid for many variations of the geometry and the operating setup. For the first time, we apply a fully electromagnetic (EM) transient 3-D high-order discontinuous Galerkin particle-in-cell method solving the complete self-consistent nonlinear Vlasov-Maxwell equations to simulate a 30-GHz high-power millimeter-wave gyrotron resonator without physical reductions. This is a computational expensive endeavor, which requires today's high-performance computing capacity. However, this enables a detailed analysis of the EM field, the excited TE2,3 mode, the frequencies, and the azimuthal particle bunching in the beam. Therefrom, we present new insights into the complex particle-field interaction of the electron cyclotron maser instability transferring kinetic energy from the electron beam to the EM field.
Growth Retardation, Early Death, and DNA Repair Defects in Mice Deficient for the Nucleotide Excision Repair Enzyme XPF

ABSTRACT Xeroderma pigmentosum (XP) is a human genetic disease which is caused by defects in nucleotide excision repair. Since this repair pathway is responsible for removing UV irradiation-induced damage to DNA, XP patients are hypersensitive to sunlight and are prone to develop skin cancer. Based on the underlying genetic defect, the disease can be divided into the seven complementation groups XPA through XPG. XPF, in association with ERCC1, constitutes a structure-specific endonuclease that makes an incision 5′ to the photodamage. XPF-ERCC1 has also been implicated in both removal of interstrand DNA cross-links and homology-mediated recombination and in immunoglobulin class switch recombination (CSR). To study the function of XPF in vivo, we inactivated the XPF gene in mice. XPF-deficient mice showed a severe postnatal growth defect and died approximately 3 weeks after birth. Histological examination revealed that the liver of mutant animals contained abnormal cells with enlarged nuclei. Furthermore, embryonic fibroblasts defective in XPF are hypersensitive to UV irradiation and mitomycin C treatment. No defect in CSR was detected, suggesting that the nuclease is dispensable for this recombination process. These phenotypes are identical to those exhibited by the ERCC1-deficient mice, consistent with the functional association of the two proteins. The complex phenotype suggests that XPF-ERCC1 is involved in multiple DNA repair processes.