Miracle-dz/UniFAR-FTUs huggingface dataset:
OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF RETINAL VENOUS OCCLUSION

Purpose: To noninvasively evaluate the retinal microvasculature in human subjects with retinal venous occlusions using optical coherence tomography angiography and assess potential clinical applications. Methods: This was a prospective, observational study of adult human subjects with clinical and imaging findings demonstrating retinal venous occlusion. Subjects underwent complete ophthalmic examination and fluorescein angiography as appropriate for their standard of care. Optical coherence tomography angiography was performed on a prototype spectral domain-OCTA system in 3 mm × 3 mm and 6 mm × 6 mm regions centered on the fovea and parafoveal areas. Retinal vasculature was assessed within three horizontal slabs consisting of the superficial, middle, and deep retina. The vasculature within each slab was reconstructed using intensity contrast-based algorithms and visualized as en-face images. Optical coherence tomography angiograms were manually segmented to verify the accuracy of the automated segmentation algorithms. Results: Optical coherence tomography angiography was able to demonstrate almost all of the clinically relevant findings in 25 subjects with acute and chronic retinal venous occlusion. These findings were consistent with clinical, anatomic, and fluorescein angiographic findings including areas of impaired vascular perfusion, retinal atrophy, vascular dilation, shunt vessels, and some forms of intraretinal edema. Conclusion: Optical coherence tomography angiography is an investigational method that generates high-resolution, noninvasive angiograms that qualitatively illustrate most of clinically relevant findings in retinal venous occlusion. Optical coherence tomography angiography corresponds well with fluorescein angiograms and in many cases provides more detailed anatomic and blood flow information. Optical coherence tomography angiography, in conjunction with standard spectral domain-OCT, is at least equally as effective as fluorescein angiography for evaluation and management of the macular complications of retinal venous occlusions.
The effect of cortisone on the metabolism of connective tissues in the rat.

Abstract Pharmacological doses of cortisone administered to rats greatly diminished the 35 S-sulfate incorporation into epiphyseal cartilage and skin. The effect on the incorporation of the 35 S-sulfate by aorta and liver was less markedly diminished. Autoradiographic and histochemical studies suggested that sulfated mucopolysaccharide synthesis was decreased. Critical evaluation of chemical methods for the estimation of hexuronic acid and hexosamine indicated diminished mucopolysaccharide or glycoprotein concentrations in most of the tissues of the cortisone-treated animals. Specifically in the liver, the total hexosamine as well as the glucosamine concentration was decreased. Decreased glucosamine-6-phosphate synthesis (amidotransferase reaction) was also observed by liver supernatants and homogenates in the cortisone-treated group. Ion-exchange chromatography of the glucosamine-6-phosphate produced by liver supernatants, with the use of labeled substrate, indicated that the observed amidotransferase suppression could not be attributed to related reactions such as concomitant increase in glucose-6-phosphatase activity.
Abnormality of CD4+CD25+ regulatory T cells in idiopathic thrombocytopenic purpura

Objectives: The aim of this study was to explore the profile and function of CD4+CD25+ regulatory T cells (Treg cells) in idiopathic thrombocytopenic purpura (ITP) patients. Methods: Treg cell numbers were analyzed by flow cytometric analysis in peripheral blood mononuclear cells collected from healthy donors or patients with ITP. Quantification of cell proliferation was assayed by an enzyme‐linked immunosorbent assay kit, based on the measurement of BrdU incorporation during DNA synthesis. Results: The percentage of Treg cells was significantly decreased in ITP patients in active and non‐remission state(5.79 ± 1.22%) when compared with the patients in remission(11.63 ± 4.56%) and to healthy subjects(12.68 ± 3.59%). The suppressive activity of Treg cells in ITP patients was also found to be impaired. Conclusion: These results suggest that decreased number and function of Treg cells might be one of mechanisms that cause immune regulation dysfunction in ITP.
Analysis of the performance of predictive SNR scalable coders

In this paper, we present an analysis of the performance of three predictive fine granular SNR-scalable coders and compare them with their non-scalable version. In our study, we assume an exponential model for the quantization noise and the use of linear prediction. Coders efficiency is assessed through the signal-to-noise ratio as a function of rate (SNR(R)) and the mean SNR. Validity of our analysis is tested by comparing theoretical results with simulations of the encoding of realizations of first order autoregressive processes. Results show that the use of coders which tolerate some prediction drift provides better results than other conventional scalable schemes.
Prolactin response to thyrotropin releasing hormone in normal subjects.

Synthetic thyrotropin releasing hormone (TRH) was administered intravenously to normal human subjects and the serum prolactin (PRL) response was measured. The effects of dose and of age and sex of the recipients on the PRL response were evaluated. The maximum increase in scrum PRL above the baseline level (max APRL) was used as the index of response. The max APRL increased linearly as a function of the log of the TRH dose between 6.25 and 100 μg of TRH, but did not increase further in response to 400 and 800 μg of TRH. Mean PRL responses did not vary with age in subjects of the same sex, but individual variability was greater in the older subjects of both sexes. PRL responses in each of 3 age groups of females, 20-39, 40-59 and 60-79 years old, were nearly double the responses observed in males of the same age groups (58.9 ± 4.7 ng/ml in all females vs 28.7 ± 2.4 ng/ml in all males, mean ± sem). In order to avoid diagnostic error in evaluating PRL response to TRH, criteria must be employed that are specif.
NUA-Prolog: An Extension to the WAM for Parallel Andorra

The Andorra Kernel Language (AKL), also known as the Agents Kernel Language, is a logic programming language that combines both don’t know nondeterminism and stream programming. This thesis reports on the design and construction of an abstract machine, the DAM, for the parallel execution of AKL programs. Elements of a compiler for the DAM are also described. As part of the development of the DAM, a bottom-up abstract interpretation for AKL and a logic semantics for the AKL, based on interlaced bilattices have also been developed. This thesis reports on the abstract interpretation and the logical semantics. This thesis is less than 100,000 words in length, exclusive of tables, bibliography and appendices.
Designing for Bodily Interplay in Social Exertion Games

While exertion games facilitate, and benefit from, social play, most exertion games merely support players acting independently. To help designers explore the richness of social play in exertion games, we present the design dimension “bodily interplay” that gives critical focus to how players’ bodies interact with one another. We offer two broad categories of bodily interplay—parallel and interdependent play—to explain how exertion games can facilitate independent and offensive/defensive-type experiences. These categories can be applied to both the physical and virtual space, and by looking at all permutations of these categories, we articulate four ways of coupling the spaces: comparative, actuated, derived, and projected coupling. This article illustrates the inspirational power of the dimensions by applying them to the analysis of four exertion games. Altogether, we articulate a vocabulary that can guide designers in the creation of social exertion games, helping players profit from the many benefits of exertion.
Targeting and plasticity of mitochondrial proteins revealed by proximity-specific ribosome profiling

The wheres and whys of protein translation Localized protein synthesis is important for a broad range of biological activities, from specifying the animal body plan to coordinating entry into the secretory pathway. Few tools are available that can investigate translation at specific subcellular sites. Jan et al. present a flexible ribosome profiling–based methodology to enable precise characterization of localized protein synthesis (see the Perspective by Shao and Hegde). Proximity-specific ribosome profiling provides a high-precision tool for looking at the mechanism of localized protein targeting and synthesis in living cells. The approach yielded a high-resolution systems-level view of cotranslational translocation at the endoplasmic reticulum. Williams et al. applied the technique to look at localized mRNA translation at the mitochondrial outer membrane. Science, this issue 10.1126/science.1257521, p. 701; see also p. 748 A new method reveals exactly which proteins are synthesized in the neighborhood of the endoplasmic reticulum and mitochondria. [Also see Perspective by Shao and Hegde] Nearly all mitochondrial proteins are nuclear-encoded and are targeted to their mitochondrial destination from the cytosol. Here, we used proximity-specific ribosome profiling to comprehensively measure translation at the mitochondrial surface in yeast. Most inner-membrane proteins were cotranslationally targeted to mitochondria, reminiscent of proteins entering the endoplasmic reticulum (ER). Comparison between mitochondrial and ER localization demonstrated that the vast majority of proteins were targeted to a specific organelle. A prominent exception was the fumarate reductase Osm1, known to reside in mitochondria. We identified a conserved ER isoform of Osm1, which contributes to the oxidative protein-folding capacity of the organelle. This dual localization was enabled by alternative translation initiation sites encoding distinct targeting signals. These findings highlight the exquisite in vivo specificity of organellar targeting mechanisms.
Understanding medial temporal activation in memory tasks: Evidence from fMRI of encoding and recognition in a case of transient global amnesia

We used fMRI to examine the activation patterns of patient AE during encoding and recognition of visual scenes during an episode of transient global amnesia (TGA) and 3 months later. Controls (n = 5) showed bilateral (R > L) activation in parahippocampal and fusiform gyri during encoding and right‐sided activation in the same regions associated with recognition of previously viewed scenes. AE showed a similar pattern at follow‐up. During acute TGA, when performance was profoundly impaired, AE showed no medial temporal activation associated with encoding of new scenes or recognition of old scenes. In both contrasts, the percent signal change in relevant medial temporal regions was more than three standard deviations below the control sample mean. She did, however, show striking bilateral hippocampal activation for recognition attempts (old + new scenes > baseline) even though retrieval was unsuccessful (55% recognition accuracy). This finding was unique to AE on this occasion. This is the first study to document normalization of both encoding and recognition activation patterns in TGA. Furthermore, the strong hippocampal activation during unsuccessful retrieval highlights important issues in interpreting memory‐related activations, particularly in dysfunctional systems. © 2007 Wiley‐Liss, Inc.
Vitellogenin mRNA from Dacus oleae: Characterization, cDNA cloning, and dependence on sex and developmental stage

Poly(A)+ RNA was isolated from 5-day-old females of the olive fruitfly Dacus oleae. In vitro translation of mRNA, followed by immunoprecipitation with anti-vitellin antiserum, demonstrated the synthesis of two vitellogenin polypeptides of 54,000 and 56,000 daltons. In sucrose gradient centrifugation, the vitellogenin mRNA sediments in the 14.4S region that corresponds to an RNA size of approximately 1,600 nucleotides. Translation of poly(A)+ RNA isolated from male flies revealed the presence of small quantities of vitellogenin mRNA, consistent with the finding of vitellogenin in male hemolymph of Dacus. Using the female poly(A)+ RNA population as template, we constructed a cDNA expression library in a lambda gt11 vector, which was screened with anti-vitellin antiserum. Four recombinant clones were isolated containing inserts of 550–800 bp*, which were identified as vitellogenin cDNA clones by hybrid-selected translation. All four cDNA clones showed crossreaction with vitellogenin genes of Drosophila melanogaster. The Dacus clones were used as probes to study vitellogenin expression during postembryonic development of Dacus. In females, vitellogenin mRNA appeared at the time of eclosion with increasing accumulation up to the 5th day of adult life; then it reached a plateau. On day 10, the mRNA titer had already started to decrease and on day 25, no vitellogenin mRNA was detectable. In males, vitellogenin mRNA was found up to the 8th day after eclosion, in very low concentrations. No vitellogenin mRNA was present during larval and pupal stages.
Parásitos intestinales en habitantes de una comunidad rural del Estado Bolívar, Venezuela

Introduccion. Las parasitosis intestinales constituyen un importante problema de salud publica por sus altas tasas de prevalencia y amplia distribucion mundial, sobre todo en las regiones tropicales y subtropicales, siendo la poblacion infantil la mayormente afectada. Objetivo. Determinar la prevalencia de parasitos intestinales en habitantes de Aripao, comunidad rural del estado Bolivar, Venezuela. Materiales y Metodos. En abril de 2005 se realizo un estudio transversal con 155 habitantes de ambos sexos. De cada uno se obtuvo una muestra fecal la cual fue analizada mediante la tecnica de examen directo, metodos de concentracion de Kato y formol-eter, cultivo en placa de agar y coloracion de Kinyoun. Resultados. La prevalencia de parasitosis intestinal fue de 83.9% (130/155). Las prevalencias por grupos de edad fueron similares (χ2 = 3.037; g.l. = 5). Ambos sexos fueron afectados por igual (p › 0.05). Se diagnosticaron 15 especies de parasitos y/o comensales. Los protozoarios fueron mas prevalentes que los helmintos. Blastocystis hominis fue el parasito intestinal mas prevalente con 60%. Se diagnosticaron 9 casos de Cryptosporidium parvum y 2 de Cyclospora cayetanensis. Entre los helmintos Ascaris lumbricoides (20%), Trichuris trichiura (9%) y Strongyloides stercoralis (4.5%) resultaron los mas comunes. De los parasitados 75.4% resulto poliparasitado (98/130). En este ultimo grupo los parasitos mas frecuentemente asociados fueron Blastocystis hominis (75.5%) y Entamoeba coli (48.9%). Conclusion. Se determino una elevada prevalencia (83.9%) de parasitos intestinales en habitantes de la comunidad rural de Aripao, estado Bolivar, Venezuela, sin predileccion por el sexo o la edad y con predominio de los protozoarios, en particular de B. hominis.
The Use of Indicators in Modified Historical Model to Estimate the Intrinsic Value of a Stock

The article mentions several methods of a fundamental analysis used to value stocks. It pri- marily focuses on the historical model. This model enables undervalued, correctly valued and overvalued stocks to be identified. The model is further modified in the article, using selected accounting indicators. The modified model versions are applied to selected stocks in the SPAD segment, Prague Stock Exchange, within the 2005-2010 period. Empirical analysis is applied to a comparison of accuracy of the accounting indicator value estimates and accuracy of stock intrinsic value estimates, both separately for each stock and accounting indicator. The com- parisons of accuracy of the accounting indicator value estimates and the accuracy of the stock intrinsic value estimates are also done based on the length of applied time period. With re- spect to the obvious fierce competition between stock issuers within the financial markets, the model enables potential investors, who are to select from an extensive offer of stocks, to make better informed investment decisions.
THE STROMAL LESION IN LATTICE DYSTROPHY OF THE CORNEA. A LIGHT AND ELECTRON MICROSCOPIC STUDY.

The corneal stromal lesions of a case of lattice dystrophy that fulfilled all the clinical and histopathologic criteria of this disease were examined by light and electron microscopy. The lesions were found to consist of two distinct parts: (1) a nonbirefringent mass of disoriented filaments of approximately one-third the diameter of normal stronml collagen fibrils and (2) a second, birefringent part containing -modified stromal lamellas with highly oriented fibrils of normal diameter but increased density. These observations suggest that the normal collagen fibril separates into filaments of smaller diameter ("fibrillary degeneration").
A Brief History of the Encoding of Hand Position by the Cerebral Cortex: Implications for Motor Control and Cognition

Encoding hand position by the cerebral cortex is essential not only for the neural representation of the body image but also for different actions based on eye-hand coordination. These include reaching for visual objects as well as complex movement sequences, such as tea-making, tool use, and object construction, among many others. All these functions depend on a continuous refreshing of the hand position representation, relying on both predictive signaling and afferent information. The hand position influence on neural activity in the parietofrontal system, together with eye position signals, are the basic elements of an eye-hand matrix from which all the above functions can emerge and could be regarded as key features of a network with several entry points, command nodes and outflow pathways, as confirmed by the discovery of a direct parietospinal projection for the control of hand action. The integrity of this system is crucial for daily life, as testified by the consequences of cortical lesions, spanning from severe paralysis to complex forms of apraxia. In this review, I will sketch my personal understanding of the scientific and conceptual trajectory of a line of investigation with many unexpected influences on cortical function and disease, from motor behavior to cognition.
N-formimidoyl thienamycin (MK0787): in vitro activity against anaerobic bacteria

The in vitro activity of N-formimidoyl thienamycin (MK0787) was tested against 239 anaerobic bacteria clinical isolates: 70 of Bacteroides fragilis, 18 of B. distasonis, 16 of B. thetaiotaomicron, 10 of B. vulgatus, 24 of Bacteroides spp. , 22 of B. melaninogenicus (all three subspecies), 26 of Fusobacterium spp. , 10 of Peptococcus spp. , 15 of Peptostreptococcus spp. , 15 of Clostridium perfringens, and 13 of Clostridium spp. Ninety-five percent of the isolates were inhibited by less than or equal to 0.125 microgram/ml, and all were inhibited by less than or equal to 4 micrograms/ml.
The effects of nocturnal compared with conventional hemodialysis on mineral metabolism: A randomized‐controlled trial

Hyperphosphatemia is common among patients receiving dialysis and is associated with increased mortality. Nocturnal hemodialysis (NHD) is a long, slow dialytic modality that may improve hyperphosphatemia and disorders of mineral metabolism. We performed a randomized‐controlled trial of NHD compared with conventional hemodialysis (CvHD); in this paper, we report detailed results of mineral metabolism outcomes. Prevalent patients were randomized to receive NHD 5 to 6 nights per week for 6to 10 hours per night or to continue CvHD thrice weekly for 6 months. Oral phosphate binders and vitamin D analogs were adjusted to maintain phosphate, calcium and parathyroid hormone (PTH) levels within recommended targets. Compared with CvHD patients, patients in the NHD group had a significant decrease in serum phosphate over the course of the study (0.49 mmol/L, 95% confidence interval 0.24–0.74; P=0.002) despite a significant reduction in the use of phosphate binders. Sixty‐one percent of patients in the NHD group compared with 20% in the CvHD group had a decline in intact PTH (P=0.003). Nocturnal hemodialysis lowers serum phosphate, calcium‐phosphate product and requirement for phosphate binders. The effects of NHD on PTH are variable. The impact of these changes on long‐term cardiovascular and bone‐related outcomes requires further investigation.
k-PCA: a semi-universal encoder for image compression

Purpose – In recent years, principal component analysis (PCA) has attracted great attention in dimension reduction. However, since a very large transformation matrix must be used for reconstructing the original data, PCA has not been successfully applied to image compression. To solve this problem, this paper aims to propose a new technique called k‐PCA.Design/methodology/approach – Actually, k‐PCA is a combination of vector quantization (VQ) and PCA. The basic idea is to divide the problem space into k clusters using VQ, and then find a PCA encoder for each cluster. The point is that if the k‐PCA encoder is obtained using data containing enough information, it can be used as a semi‐universal encoder to compress all images in a given domain.Findings – Although a k‐PCA encoder is more complex than a single PCA encoder, the compression ratio can be much higher because the transformation matrices can be excluded from the encoded data. The performance of the k‐PCA encoder can be improved further through learn.
The effect of maternal anemia on anthropometric measurements of newborns.

يثيدح لافطلأاو ةدلاولا مسق نم 3688 ةساردلا تلمش :ةقيرطلا لوبنطسا – لاتراك – رادريق يفطل روتكدلا ىفشتسم يف ةدلاولا . م2006 ربمسيد ىتحو م2005 رياني ينبام ةرتفلا للاخ ،ايكرت – ديلاوملل ردصلاو سأرلا طيحم ،لوطلا ،نزولا تاسايق ليجست تم لماولحا ءاسنلل لماكلا مدلا دادعت مييقت ىرجأُ امك . ددلجا نم لقا ينبولجوميهلا زيكرت تاوذ تاهملأا مييقت تم . تاروكذلما ميسقت تمو . )مدلا رقف( ايمينلأاب تاباصم نهنأ يلع 11g/dl :تاعومجم ثلاث يلإ )مدلا رقف( ايمينلأاب تاباصلما تاهملأا ناك اذإ ةدالحا ايمينلأاب ةباصم ملأا ربتعتو ،ةدالحاو ةلدتعلما ،ةفيفلخا ناك اذإ ةلدتعلمابو ،7g/dl نم لقأ ينبولجوميهلا زيكرت يوتسم ينب ينبولجوميهلا زيكرت يوتسم ناك اذإ ةفيفلخاو ،8.9-7.0g/dl نم ددلجا ديلاوملل ةيرشبلا تاسايقلا ةنراقم تم . 10.9-9.0g/dl ةباصم ريغلاو ةباصلما تاعومجلما يف تاهملأا