Miracle-dz/UniFAR-FTUs huggingface dataset:
Tolerability of atypical neuroleptics and acetylcholinesterase inhibitors when treating neuropsychiatric symptoms in Parkinson's disease

edu Background: Treating neuropsychiatric problems in Parkinson’s disease (PD) remains challenging. Only rivastigmine has US Food and Drug Administration approval for the treatment of PD dementia. Some studies have shown that atypical neuroleptics adequately improve hallucinations while others suggest that side effects and increased mortality negate benefit. We utilized a chart review to assess the tolerability and efficacy of commonly used agents for neuropsychiatric symptoms in PD. Methods: We reviewed patients with a PD diagnosis in our clinic database who were being treated with antidementia agents (donepezil, galantamine, rivastigmine, memantine) or atypical neuroleptics (quetiapine, olanzapine, clozapine) by two PD specialists over 13 years. We determined tolerability by therapy retention in comparison with the accepted gold standard, ie, rivastigmine for dementia and clozapine for hallucinations. Clinician documentation of patient/ caregiver or personally perceived clinical improvement was recorded to define therapeutic response. Secondary outcome measures were death, treatment-limiting side effects, and weight change. Results: A total of 171 PD patients met criteria for study inclusion. All medications were similarly retained in comparison with the standard, with the exception of donepezil which was significantly better ( P , 0.02) than rivastigmine. Using the documentation metric, no medication was statistically superior to its standard. Olanzapine approached significance because it was inferior to the clozapine standard (P , 0.08). Secondary outcome measures were similar among medications. Conclusion: We conclude that, as a group, acetylcholinesterase inhibitors, atypical neuroleptics, and memantine are well tolerated in treating either cognitive difficulties or hallucina tions in PD. They appear to offer variable levels of clinical benefit, as well per documented therapeutic responses. Side effects, death, and weight change were not significantly different
Tranquilizing effect of color reduces aggressive behavior and potential violence.

I would like to report on a significant use of color to reduce potential or actual aggression. It has been discovered that the use of a specific shade of pink can have a moderating effect on subjects experiencing feelings of anger or agitation. The calming effect of pink if appropriately applied, relaxes hostile or agitated behavior in approximately ten to fifteen minutes. In 1978, Glen Wylie of Santa Ana, California, showed John N. Ott, noted photo-biologist, a Kinesoid experiment utilizing the colors pink and blue. If a two foot by three foot piece of bright pink construction paper is placed in front of a subject's eyes, the response is a significant loss of muscular strength. In the experiment, the subject stretches his arm straight out in front of his body, thereby creating a 90° angle. The experimenter's goal is to bring the subject's arm down to the hips. The subject attempts to resist this effort by exercising maximum resistance at the agreed upon command. It
Thrombocytopenia in chronic liver disease due to hepatitis c virus

Objectives: To evaluate the frequency of thrombocytopenia in chronic liver disease due to hepatitis C virus (HCV) infection. Patients and methods: In this prospective study, patients with chronic liver disease (CLD) due to HCV were assessed using Child-Pugh class. All had full blood count, peripheral smear, Anti-HCV antibodies, abdominal ultrasound and esophago-gastroduodenoscopy. Results: Total number of patients were 155 [69 male (44.5%), 86 female (55.5%)]. Mean age was 43.58 years. Fifty patients (32.3%) had thrombocytopenia (platelet count 40 years) as compared to age
Provider-initiated counselling and testing (PICT): An overview

South Africa has the highest number of people living with HIV in the world. Despite this, many South Africans do not know their HIV status and uptake of voluntary counselling and testing (VCT) has been suboptimal. In clinical settings there are many missed opportunities for HIV diagnosis as most patients are not routinely offered HIV counselling and testing (HCT). Provider-initiated counselling and testing (PICT) has been introduced to ensure that HCT becomes the standard of care in all consultations with health providers. PICT promotes universal access to prevention, care and treatment services for all clients by increasing the utilisation and acceptance of HCT services. This article outlines the rationale for PICT as well providing an overview of the implementation protocol that will equip health care providers with the knowledge required to integrate HCT into routine medical care.
The network of nitrifying and pathogenic prokaryotic interactions in a recirculating aquaculture system of a sole (Solea senegalensis) hatchery

Prokaryotic interactions in recirculating aquaculture systems (RAS) environmental communities may play a crucial role in driving their functional potential. However, these interactions are often neglected. The aim of this work is to detect prokaryotic interactions in a Solea senegalensis RAS, through the definition of relevant taxa and cluster identification using co-variance and co-occurrence tools. Amplicon sequence variants (ASV) were obtained from the water, tank biofilm, and biofilters of two systems, pre-ongrowing and weaning, and the study focuses on two microbial target groups, the potentially pathogenic and the nitrifying prokaryotes. No significant negative correlations were found with any target ASVs, indicating a mostly cooperative environment. As expected, ammonia oxidizing bacteria (Nitrosomonas) and archaea (Candidatus Nitrosopumilus) were found to be positively interacting with the nitrite oxidizing bacteria Nitrospira. However, no interactions were found between them, and results hint at a niche differentiation based on ammonia competition. Nitrospira also showed subcommunities with no ammonia oxidizing archaea or ammonia oxidizing bacteria correlations, hinting at a separate functional role of complete ammonia oxidation to nitrate for some Nitrospira ASVs. Two taxa commonly associated with pathogenic outbreaks, Tenacibaculum and Vibrio, had a significant positive correlation in one of the systems. With no outbreaks reported, this association may prove relevant in disease preventions and to improve outbreak predictions. Future studies may further elucidate this interaction, as cumulative evidence is still needed to better understand this correlation.
A retrospective analysis based on multiple machine learning models to predict lymph node metastasis in early gastric cancer

Background Endoscopic submucosal dissection has become the primary option of treatment for early gastric cancer. However, lymph node metastasis may lead to poor prognosis. We analyzed factors related to lymph node metastasis in EGC patients, and we developed a construction prediction model with machine learning using data from a retrospective series. Methods Two independent cohorts’ series were evaluated including 305 patients with EGC from China as cohort I and 35 patients from Spain as cohort II. Five classifiers obtained from machine learning were selected to establish a robust prediction model for lymph node metastasis in EGC. Results The clinical variables such as invasion depth, histologic type, ulceration, tumor location, tumor size, Lauren classification, and age were selected to establish the five prediction models: linear support vector classifier (Linear SVC), logistic regression model, extreme gradient boosting model (XGBoost), light gradient boosting machine model (LightGBM), and Gaussian process classification model. Interestingly, all prediction models of cohort I showed accuracy between 70 and 81%. Furthermore, the prediction models of the cohort II exhibited accuracy between 48 and 82%. The areas under curve (AUC) of the five models between cohort I and cohort II were between 0.736 and 0.830. Conclusions Our results support that the machine learning method could be used to predict lymph node metastasis in early gastric cancer and perhaps provide another evaluation method to choose the suited treatment for patients.
Predicting cross-protection against foot-and-mouth disease virus strains by serology after vaccination

Serology is widely used to predict whether vaccinated individuals and populations will be protected against infectious diseases, including foot-and-mouth disease (FMD), which affects cloven-hoofed animals. Neutralising antibody titres to FMD challenge viruses correlate to protection against FMD, for vaccinated cattle that are infected with the same strain as in the vaccine (homologous protection). Similar relationships exist for cross-strain protection between different vaccine and challenge viruses, although much less data are available for these heterologous studies. Poor inter-laboratory reproducibility of the virus neutralisation test (VNT) also hampers comparisons between studies. Therefore, day-of-challenge sera (n = 180) were assembled from 13 previous FMD cross-protection experiments for serotypes O (n = 2), A (n = 10), and SAT 2 (n = 1). These were tested by VNT against the challenge viruses at the FMD FAO World Reference Laboratory (WRLFMD) and the titres were compared to challenge outcomes (protected or not). This dataset was combined with equivalent serology and protection data for 61 sera from four cross-protection experiments carried out at WRLFMD for serotypes O (n = 2), A (n = 1), and Asia 1 (n = 1). VNT results and protection outcomes were also analysed for a serotype O cross-protection experiment involving 39 cattle, where the sera were not available for retesting at WRLFMD. Three categories of association between heterologous neutralising antibody titre and heterologous protection were found (Group 1–3). The log10 reciprocal titres associated on average with 75% protection (with 95% credible limits) were: Group 1: 2.46 (2.11–2.97); Group 2: 1.67 (1.49–1.92); Group 3: 1.17 (1.06–1.30). Further cross-protection data are needed to understand the factors that underpin this variability and to develop more robust antibody thresholds. Establishing cut-off serological titres that can be used to score the adequacy of vaccine-induced immunity will facilitate the monitoring and thereby the performance of FMD vaccination in the field.
EXPERIMENTAL ASPECT OF FIXED ERUPTION DUE TO ALURATE, A COMPOUND OF ALLONAL

In 1903, Fischer and von Mering 1 described the barbituric acid hypnotic diethylbarbituric acid (diethyl malonyl urea), introduced as Veronal. This is now official in the United States Pharmacopeia X as barbital. There were also introduced the sodium salts of barbital under the proprietary names Medinal and Veronal Sodium. Some years later a second derivative of the series was announced; in this, one of the ethyl groups was displaced by a phenyl group. This derivative, phenylethylbarbituric acid, was the proprietary designated as Luminal; the same substance is now official under the name phenobarbital. In the meantime, numerous hypnotics of the barbituric acid series 2 in which the ethyl groups are replaced by other alkyl or aryl radicals have been developed, including, among the more common ones, amytal (isoamylethylbarbituric acid), dial (diallylbarbituric acid), neonal (N-butylethylbarbituric acid), nostal (isopropyl bromallyl barbituric acid) and pentobarbital sodium. In February, 1922, Allonal (Numal) was introduced
The Education of Children in Out-of-home Care

Abstract In spite of a high investment in out-of-home care services across Australia, the educational attainment of children in care remains an issue of concern. This paper discusses findings from a study designed to identify the factors that promoted educational attainment of children in care based on 18 university-educated women with a care background. The narratives of these women from primary schooling through to graduating from a university were collected and analysed using narrative inquiry. The women's narratives strongly suggested that the educational needs of children in care vary according to individual care circumstances and individual characteristics, and can be identified in five groups: Destined, Decision, Determined, Denied, and Delayed. It was concluded that the promotion of educational attainment for children in care requires carefully tailored support and resources following assessment based on this information.
Sudden Unexpected Death In Epilepsy (SUDEP) – an update

Summary Introduction SUDEP is not so rare event, unexplained, underused and underestimated. Its awareness has recently contributed to a number of initiatives for global action and clinical and experimental research. Aim To undertake a literature review so as to update various aspects of SUDEP: pathophysiological mechanisms, potential markers for autonomic dysfunctions and risk factors, AEDs effects, non-AED management options, forensic/autopsy, patient-physician communications in patients with SUDEP risk. Method A literature review, up to Nov. 2012, was conducted using PubMed-Medline for SUDEP, no indexed citation and relevant papers. Review Interactions between the central and peripheral origin of cardiac and respiratory dysfunctions, triggered by epileptiform discharges in the cortical representation of the autonomic functions, may lead to SUDEP during simple partial autonomic seizures - even without other components of a seizure. A number of potential biomarkers of autonomic dysfunctions and risk of SUDEP are identified and proposed to use in its prevention: heart rate variability, long and short QT, arrhythmias, asystole, oxygen desaturation, apneas, hypoxia, postictal EEG suppression, circadian seizure pattern. Conclusions Risk factors for SUDEP, AEDs effects, non-AED management of preventive options and forensic autopsy in diagnosis of SUDEP are discussed. Periictal long term video EEG, ECG and oxygen saturation monitoring may contribute to better understanding of SUDEP mechanisms and eventually to its prevention. SUDEP occurs as fatal coexistence of several predisposing risk factors. Diagnosis of SUDEP is underestimated and underused. In patient with high risk factors for SUDEP, in particular, with AED noncompliance, prognosis of epilepsy should be discussed with patient.
GPs' preferences: What price fee-for-service?

In mixed health care systems a crucial condition for the success of Managed Care (MC) plans is to win over a su±cient number of general practitioners (GPs) acting as gatekeepers. This contribution reports on GPs' willingness-to-accept (WTA) or compensation asked, respectively, for changing from conventional fee-for-service to MC practice. Some 175 Swiss GPs participated in discrete choice experiments which permit to put a money value on their status quo bias. Regardless of whether effects coding or dummy coding is used to measure status quo bias, Swiss GPs require at least 16 percent of their current average income to give up fee-for-service in favor of MC practice.
Multi-task Weld Seam Recognition Network for Welding Robot based on Structured-light Vision

Robot welding system with structured light vision has been widely used in chemical industry construction, aerospace, and other fields for the welding tasks that require high precision standard. The accuracy of weld recognition is the key to improving weld quality and the robot servo performance. The challenge of weld seam detection is how to deal with the influence of the arc and splash which are existing commonly during the welding process. In this paper, a novel contour-based approach has been developed to detect the weld seam in terms of key feature points which are useful for welding robots to make the welding planning. The proposed network can process multitask simultaneously, and it can not only estimate the location of the weld key-point but also can identify different weld joints without any preprocessing or postprocessing. The experimental result shows that the actual weld seam detection error is within 0.3 mm in the noisy welding process and that illustrates the effectiveness of the proposed work.
SERUM ZINC LEVEL IN PATIENTS WITH SIMPLE FEBRILE SEIZURE

Objective To evaluate the serum zinc level of the patients with simple febrile seizure and compare them with febrile children without seizure. Materials & Methods This prospective case - control study was performed on 60 patients aged 6 months to 6 years from Apr. 2009 to Jan.2010 in Ghaem, Imam Reza and Dr. Sheikh Hospitals in Mashhad. The serum zinc level was assessed and compared between the cases (30 individuals who suffered from simple febrile seizure) and the controls (30 individuals who had fever without seizure). Results Mean serum zinc level was 663.7 µg /l and 758.33 µg /l in the case group and the control group, respectively (P Conclusion It was revealed that the serum level of zinc was significantly lower in children with simple febrile seizure in comparison with febrile children without seizure.
Arterial Baroreflexes in Humans

The sections in this article are: 1 Techniques 1.1 Carotid Sinus Massage 1.2 Electrical Stimulation of Carotid Sinus Nerves 1.3 Section or Anesthesia of Carotid Sinus Nerves and Vagi 1.4 Occlusion of Common Carotid Arteries 1.5 Neck Chamber 1.6 Vasoactive Drugs 1.7 Nonselective Techniques 2 Arterial Baroreceptor Control of Heart Rate 2.1 Autonomic Mediation 2.2 Other Properties 2.3 Relationship to Base-Line R-R Interval 2.4 Relationship to Respiratory Cycle 3 Arterial Baroreceptor Control of Atrioventricular Conduction and Ventricles 4 Carotid Baroreceptor Control of Blood Pressure 5 Carotid Baroreceptor Influence on Cardiac Output and Total Peripheral Resistance 6 Arterial Baroreceptor Control of Regional Circulations 7 Arterial Baroreceptor Control of Veins 8 Set Point of Carotid Baroreflex 9 Aortic Baroreflexes 10 Factors That Modify Arterial Baroreceptor Control of Circulation 10.1 Age 10.2 Exercise 10.3 Mental Stress 10.4 Sleep 10.5 Anesthesia 10.6 Central Blood Volume and Posture 11 Pathological States 11.1 Hypertension 11.2 Heart Disease 11.3 Carotid Sinus Syndrome 11.4 Other Pathological Conditions 12 Modification of Arterial Baroreflexes by Drugs 12.1 β-Adrenergic Antagonists 12.2 Cardiac Glycosides 12.3 Antihypertensive Drugs
Elder Mistreatment Among Four Asian American Groups

Abstract Using 14 statements, this study examined similarities and differences among four groups of elders (American-born Chinese Americans, American-born Japanese Americans, first-generation Korean Americans, and first-generation Taiwanese Americans) with regard to tolerance for elder mistreatment behaviors, tendency to victim blame, and attitudes toward reporting elder mistreatment. The American-born groups were more likely to be tolerant of verbal abuse, less likely to blame the elderly parents for causing the mistreatment by their grown children, and more favorable toward reporting elder mistreatment to the authorities. The Korean Americans differed significantly from the other three groups: They had a greater tolerance for financial exploitation, were more likely to blame the elder as the cause of the mistreatment, and not favorable toward reporting and outside intervention. Among all participants, tolerance for elder mistreatment was strongly associated with victim blaming and not favoring reporting and outside intervention. The large percentages of “Don't know” and “It depends” responses to the statements among all four groups indicate that these groups are unfamiliar with the problems of elder mistreatment.
PENGARUH KEWAJARAN HARGA DAN CITRA PERUSAHAAN TERHADAP KEPERCAYAAN DAN LOYALITAS KONSUMEN

Based on data from the Association of Indonesian Motorcycle Industry (AISI) in 2016, Honda is a company that dominate the scooter market in Indonesia from year to year. This study aims to determine the role of reasonableness of price and corporate image to the trust and loyalty of consumers scooter Honda. Testing of research hypothesis using Structural Equation Modeling (SEM) analysis technique using AMOS 21 support, using IBM SPSS Statistics 22 for validity and reliability test. Samples of 100 respondents, taken using Purposive Sampling technique, with the criteria of respondents using Honda scooter continuously, at least for 1 last year, and live in Denpasar. The result shows that price fairness has positive significant effect to consumer trust. The image of the company has a significant positive effect on consumer's trust, price fairness has no significant effect on consumer loyalty, corporate image has a significant positive effect on consumer loyalty, and consumer trust has positive effect not significant to loyalty consumer.
Issues influencing medication adherence in Black women with hypertension

The purposes of this study were to: (a) describe the differences in adherent and nonadherent Black women who have hypertension (HTN), (b) examine issues that influence medication adherence, and (c) explore the relationship of reactant behaviors and medication adherence. Cox‘s interaction model of client health behavior was used to guide this study. Client singularity background variables: demographic characteristics (age and education), social influence (religion), previous health care experience (family history of HTN, comorbidities, number of medications, blood pressure [BP], and body mass index), and environmental resources (income and type of health coverage) along with client singularity dynamic variables: intrinsic motivation (reactance), cognitive appraisal (HTN knowledge, self-care of HTN, trust in health care provider, and coping), and affective response (perceived racism and depression) were examined to determine their influence on the health outcome, medication adherence. A cross-sectional, correlational non-experimental study was conducted with a convenience sample of 80 Black women who were taking antihypertensive prescription medications for blood pressure control. Over half of the participants (56%) were single, divorced, or widowed. Ages ranged from 19 to 60 with a mean age of 47.8 (SD ± 9.2). Almost one-third 30% (n=24) of the participants reported household incomes levels at or below the federal poverty level. The majority of the sample was employed (67%), physically inactive (90%), overweight/obese (88%), and had a history of smoking (54%). The study results did not show a difference between those who adhere to antihypertensive medications and those who do not. Also, there was no relationship between reactant behaviors and medication adherence. However, in the optimal predictive model, those aged 40-49 were less likely to be adherent to their antihypertensive medications. In contrast, those who took 5 to 7 medications were more likely to be adherent. Trust in the health care provider was highly associated with adherence to the medication treatment regimen. These results are congruent with the expectation that trust in the health care provider promotes better medication adherence. Future research should continue to identify factors that influence adherence to the treatment regimen among Black women with HTN and develop interventions that facilitate their ability to better manage their HTN and thus, maintain BP control.