Miracle-dz/UniFAR-FTUs huggingface dataset:
DOG1 is a sensitive and specific immunohistochemical marker for diagnosis of canine gastrointestinal stromal tumors

Gastrointestinal stromal tumors (GISTs) and leiomyosarcomas are histologically similar primary neoplasms commonly occurring in the gastrointestinal tract of dogs and humans. Immunohistochemical staining (IHC) is needed to differentiate between these 2 entities and positive reactivity for KIT (cluster of differentiation [CD]117) is regarded as the gold standard for diagnosis of canine GIST. Studies estimate 5–10% of human GISTs stain negative or only weakly positive for KIT and have identified DOG1 (discovered on gastrointestinal stromal tumors protein 1) as a highly sensitive and specific marker for human GISTs. The purpose of this study was to evaluate immunoreactivity of a commercially available DOG1 antibody for use in diagnosis of canine GISTs. Fifty-five primary mesenchymal gastrointestinal tumors with histologic features consistent with GIST or leiomyosarcoma were evaluated via IHC for KIT, DOG1, and desmin. A subset of tumors was additionally evaluated for reactivity for smooth muscle actin (SMA). Thirty-three tumors (60%) were diagnosed as GIST based on positive immunoreactivity for KIT or DOG1 regardless of reactivity for desmin or SMA. Most GISTs (32/33, 97.0%) had similar staining for both KIT and DOG1. DOG1 expression was identified in 2 tumors (1 study tumor and 1 additional tumor) negative for KIT and desmin that had histologic features consistent with KIT-negative, platelet-derived growth factor receptor-alpha (PDGFRA)-mutant human GISTs. Our results suggest that DOG1 has improved specificity and sensitivity to that of KIT for differentiating between canine GISTs and leiomyosarcomas. Inclusion of both DOG1 and KIT IHC in diagnostic panels will improve the accuracy of canine GIST diagnosis.
The Contour Electrode Array: Safety Study and Initial Patient Trials of a New Perimodiolar Design

Objective The aim of these studies was to investigate the insertion properties and safety of a new intracochlear perimodiolar electrode array design (Contour). Background An electrode array positioned close to the neural elements could be expected to reduce stimulation thresholds and might potentially reduce channel interaction. Methods Two sequential studies were conducted. In study 1, the Contour electrode array was inserted in 12 human temporal bones. After cochlear surface preparation, the position of the array was noted and the basilar membrane was examined for insertion damage. On the basis of the outcome of this temporal bone study, study 2 investigated the Contour array, mounted on a Nucleus CI-24 M device and implanted in three adult patients. Results Study 1 showed that in 10 temporal bones, the Contour array was positioned close to the modiolus, and the basilar membrane was intact. In the two remaining bones, the arrays had pierced the basilar membrane and were positioned in the scala vestibuli apical to the penetration. Statistical analysis showed an equivalent probability of insertion-induced damage of the two array designs. In study 2, image analysis indicated that the Contour electrodes were positioned closer to the modiolus than the standard Nucleus straight array. Lower T and C levels, but higher impedance values, were recorded from electrodes close to the modiolus. Initial speech perception data showed that all patients gained useful open-set speech perception, two patients achieving scores of 100% on sentence material 3 months postoperatively. Conclusions The temporal bone studies showed the Contour electrode array to be generally positioned closer to the modiolus than the standard Nucleus straight array, and to have an equivalent probability of causing insertion-induced damage.
The productive service employee: personality, stress, satisfaction and performance

Purpose The purpose of this study is to more closely examine the trait antecedents and outcomes of frontline employee productivity propensity. The study is the first to use a job demands-resources perspective on productivity propensity and it reveals that the inclusion of the construct into service worker personality studies significantly improves the explanatory ability of hypothesized models. Design/methodology/approach The study follows a job demands-resources perspective and uses an empirical study that included two subsamples: banking and health care. Path analyses were performed using two-group modeling to test the hypotheses. Mediation and hierarchical regressions were also used. Findings The findings indicate that the conscientiousness trait has a consistent effect on productivity propensity. More importantly, the findings reveal that productivity propensity influences role ambiguity, job satisfaction and self-rated service performance and that the addition of the construct into personality studies significantly improves the explanatory ability of personality models. Research limitations/implications This study presents further evidence that productivity propensity is an important construct in services research. Beyond previously established influences on bottom-line service productivity and manager-rated work performance, the current work indicates that it also influences FLE stress, engagement and work outcomes. Practical implications Managers work under pressures to ensure service productivity and are well aware of the importance of selecting job applicants who will fit the service role. This study provides additional evidence that the productivity propensity work resource should be considered when selecting employees. The work also suggests that customer workload and the standardization of the service environment impacts the influence of productivity propensity on service outcomes. Social implications Given the importance of transformative service experiences that uplift the experiences of consumers and employees, the productivity propensity of frontline service employees not only impacts the ability of the employee to satisfy customer needs, but also leads the employee to experience increased job satisfaction. Originality/value This work is the first work to consider the effects of productivity propensity from a job demands-resources perspective and, as such, the first to examine the influence of the construct on job satisfaction and service delivery.
The impact of pay knowledge on organisational performance : investigating Finnish profit-sharing schemes

Aalto University, P.O. Box 11000, FI-00076 Aalto www.aalto. fi Author Christina Sweins Name of the doctoral dissertation The impact of pay knowledge on organisational performance: Investigating Finnish profitsharing schemes Publisher Aalto University School of Science Unit Department of Industrial Engineering and Management Series Aalto University publication series DOCTORAL DISSERTATIONS 35/2011 Field of research Work psychology and leadership Manuscript submitted 8 November 2010 Manuscript revised 24 March 2011 Date of the defence 13 May 2011 Language English Monograph Article dissertation (summary + original articles) Many studies have been carried out on the impact of pay systems on both employee attitudes and organisational performance. However, it is still unclear how the outcomes are developed. In this thesis my aim has been to study the impact of pay knowledge on employee attitudes and organisational performance in the context of Finnish personnel funds, which are deferred profit-sharing schemes. The findings in this thesis are based on four separate articles. By pay knowledge I mean employee knowledge of both joint and firm specific principles of personnel funds. The data used in the articles were collected using a questionnaire in 31 organisations and interviews in 36 organisations that have personnel funds. Additionally, financial data was gathered for personnel fund companies and comparison companies. The results reveal that the impact of pay knowledge is directly connected to performance and not mediated through pay satisfaction as earlier research argues. This finding suggests that pay knowledge may have a stronger independent impact on the effectiveness of the pay system than previously believed. I argue further that actual knowledge is a more reliable measure than perceived knowledge in estimating the relationship between pay knowledge and pay effectiveness, and thus researchers should prefer measures of actual knowledge. To enhance knowledge about the personnel fund, it is not enough to just provide feedback on financial figures. Communication about fund related matters is important in order to increase pay knowledge and the employees’ ‘line of sight’. The results suggest, moreover, that making subjective performance assessments based on uninformed respondents may be a more serious source of bias than single respondent bias. This would mean that many surveys on the financial impacts of the pay system could be done more economically since there would be less need to gather a large number of respondents from individual firms.
A new type of headache, headache associated with airplane travel: Preliminary diagnostic criteria and possible mechanisms of aetiopathogenesis

Background: In recent years, there has been an increase in the reports indicating a form of headache that occurs during commercial aircraft travel. This headache, called airplane headache by some authors, is believed to be a new type of headache. The headache has very specific characteristics and all of the cases exhibited very stereotypical symptoms. Methods: The headache starts suddenly during the ascent and/or descent of the commercial aircraft. It has a mean duration of 20 minutes, which is usually unilateral and commonly localized to periorbital region. The headache is described to be severe, and has a stabbing or jabbing nature, and generally subsides in a short time. In some cases, an organic cause can be identified whereas in others no organic pathology could be found. Results and conclusion: We described the clinical features of 22 cases who suffered from a headache that occurred during airplane travel. We examined other cases with similar features reported in the literature and proposed preliminary diagnostic criteria for this new form of headache. We also discussed the possible patholophysiological mechanisms that may cause this headache.
Radiology of the Petromastoid Canal

Objective: The petromastoid canal is a thin structure that connects the mastoid antrum with the posterior cranial fossa and houses subarcuate blood vessels and prolongation of the dura. The current retrospective study was designed to investigate radiology of the petromastoid canal in different age groups and to determine whether increasing the scanner's resolution could enhance the detection capability of this structure. Methods: Axial sections of 504 high-resolution computed tomographic images obtained with 0.6-, 1.1-, or 1.3-mm-thick slices through the petrous bones were reviewed. Sixteen asymmetric images were excluded from the statistical analysis. Type I petromastoid canal was invisible; Type II and Type III appeared as thin channels less than 0.5 and 0.5 to 1 mm in width, respectively, and Type IV was greater than 1 mm wide. Results: The petromastoid canal Type II was detected more frequently in patients older than 5 years (p < 0.0001) and Type IV was demonstrated more often in children up to age 5years (p < 0.0001). The occurrence of a Type I petromastoid canal was not dependent on the age of the patients or the resolution of the images (p = 0.82). Increasing the resolution failed to improve the visibility of the petromastoid canal or the ability to detect it. A wide petromastoid canal (>2 mm) was significantly more common in younger patients (22.2% versus 2.4% in the older group) (p < 0.0001). A petromastoid canal beginning medially directly from the internal auditory canal was detected in 4 of 488 (0.8%) images. The lateral opening of the petromastoid canal can be found posteriorly to the medial orifice, anteriorly to it, or at the same level. The posterior lateral opening was demonstrated to be more common than the other two types in patients younger than 5 years, and the anterior opening was detected more frequently in older patients (p = 0.0006). Conclusion: The shape and width of the petromastoid canal differ radiologically between populations younger and older than 5 years of age. The findings of the current study may be important for otolaryngologists engaged in cochlear implantation or involved in treating otogenic intracranial complications, especially in young children.
The view from over there: reframing the OSCE through the experience of standardised patient raters

Ratings awarded by standardised patients (SPs) in UK objective structured clinical examinations (OSCEs) are typically based on humanistic (non‐technical) skills and are complementary to clinician‐examiner ratings. In psychometric terms, SP ratings appear to differ from examiner ratings and improve reliability. For the first time, we used qualitative methods from a constructivist perspective to explore SP experiences of rating, and consider how these impact our understanding of assessment.
Comparison of Bankruptcy Prediction Models in Relation to SMEsegment in the Czech Republic

The good and stable financial situation of enterprises is the factor which eliminates credit risk of a bank, so the prediction of a bankruptcy and a credit risk of a bank is an unflagging object of a discussion. We focus on small and medium sized enterprises (SMEs) considering the fundamental role played in the Czech economy and the considerable attention placed on SMEs. The aim of this article is the comparison of the real predicting abilities of several bankruptcy models. We have chosen the Altman Z-score, the Ohlson O-score, the Zmijewski’s model, the Taffler’s model, and the IN05 model. The basic form of the models is used as proposed by their authors. The results are compared using the classification table and ROC curve.
Suppression of Ovarian Follicle Activation in Mice by the Transcription Factor Foxo3a

Foxo transcription factors have been implicated in diverse biological processes, including metabolism, cellular stress responses, and aging. Here, we show that Foxo3a–/– female mice exhibit a distinctive ovarian phenotype of global follicular activation leading to oocyte death, early depletion of functional ovarian follicles, and secondary infertility. Foxo3a thus functions at the earliest stages of follicular growth as a suppressor of follicular activation. In addition to providing a molecular entry point for studying the regulation of follicular growth, these results raise the possibility that accelerated follicular initiation plays a role in premature ovarian failure, a common cause of infertility and premature aging in women.
Both the Middle Temporal Gyrus and the Ventral Anterior Temporal Area Are Crucial for Multimodal Semantic Processing: Distortion-corrected fMRI Evidence for a Double Gradient of Information Convergence in the Temporal Lobes

Most contemporary theories of semantic memory assume that concepts are formed from the distillation of information arising in distinct sensory and verbal modalities. The neural basis of this distillation or convergence of information was the focus of this study. Specifically, we explored two commonly posed hypotheses: (a) that the human middle temporal gyrus (MTG) provides a crucial semantic interface given the fact that it interposes auditory and visual processing streams and (b) that the anterior temporal region—especially its ventral surface (vATL)—provides a critical region for the multimodal integration of information. By utilizing distortion-corrected fMRI and an established semantic association assessment (commonly used in neuropsychological investigations), we compared the activation patterns observed for both the verbal and nonverbal versions of the same task. The results are consistent with the two hypotheses simultaneously: Both MTG and vATL are activated in common for word and picture semantic processing. Additional planned, ROI analyses show that this result follows from two principal axes of convergence in the temporal lobe: both lateral (toward MTG) and longitudinal (toward the anterior temporal lobe).
Production of purified mrsacin from local clinical strain of methicillin-resistant Staphylococcus aureus and its applicability as antimicrobial

Strains MRSA that acquired a specific gene makes for resistant to most (beta-lactam) antibiotics. Also common resistance to other antibiotics especially in hospital-associated, these organisms microbiology are nosocomial pathogens serious and finding an effective treatment can be challenging. Community associated MRSA strains are outside hospitals originated having moved into hospitals and become resistant to drugs increasing than beta-lactams [1]. (Methicillin-resistant Staphylococcus aureus) resistant usually to several type antibiotics and also resistance to ßlactam and a particular shows ability to spread in most hospitals and present now in most countries of Iraq [2]. Risk factors for the hospital acquisition of MRSA include prolonged hospitalization that stay in an intensive care unit, chronic diseases such as chronic renal failure and malignancy, prior exposure to antibiotics, surgery and contact with a patient known to be colonized or infected with MRSA [3]. Bacteriocins are antimicrobial peptides or proteins ribosomally safe substances that are non-toxic to eukaryotic cells. Bacteriocins bacterially produced natural peptides released by different varieties of bacteria and archea that are active against other bacteria and the producer has a specific immunity mechanism [4]. Bacteriocins which have inhibitory effects towards sensitive strains are produced by both gram-positive and gram-negative bacteria, Bacteriocins from lactic acid bacteria are used in food perecierpitive like in dairy products. It has a useful use in health care products and cosmetics for treatment of acne, also being used inhibition of dental caries in toothpaste and mouthwash for the periodontal diseases [5]. Staphylococcin Bac188 also showed very potent activity against many clinical isolates of Mycobacterium tuberculosis. Staphylococcin Bac188) Staphylococci are known to produce a wide variety of inhibitory substances [6]. Other antimicrobial substances produced by staphylococci have been categorized as true bacteriocins [7].
A Free Interface Model for Static/Flowing Dynamics in Thin-Layer Flows of Granular Materials with Yield: Simple Shear Simulations and Comparison with Experiments

Flows of dense granular materials comprise regions where the material is flowing, and regions where it is static. Describing the dynamics of the interface between these two regions is a key issue to understand the erosion and deposition processes in natural environments. A free interface simplified model for non-averaged thin-layer flows of granular materials has been previously proposed by the authors. It is a coordinate-decoupled (separated variables) version of a model derived by asymptotic expansion from an incompressible viscoplastic model with Drucker-Prager yield stress. The free interface model describes the evolution of the velocity profile as well as the position of the transition between static and flowing material. It is formulated using the coordinate $Z$ in the direction normal to the topography and contains a source term that represents the opposite of the net force acting on the flow, including gravity, pressure gradient, and internal friction. In this paper we introduce two numerical methods to deal with the particular formulation of this model with a free interface. They are used to evaluate the respective role of yield and viscosity for the case of a constant source term, which corresponds to simple shear viscoplastic flows. Both the analytical solution of the inviscid model and the numerical solution of the viscous model (with a constant viscosity or the variable viscosity of the $\mu(I)$ rheology) are compared with experimental data. Although the model does not describe variations in the flow direction, it reproduces the essential features of granular flow experiments over an inclined static layer of grains, including the stopping time and the erosion of the initial static bed, which is shown to be closely related to the viscosity for the simple shear case.
Lack of effect of a small dose of flumazenil in reversing short-term tolerance to benzodiazepines in normal subjects

Twelve normal volunteers received two courses of 7 days of either lorazepam (2 mg every morning; six subjects) or oxazepam (30 mg every morning; six subjects). After one of the courses, 0.2 mg of flumazenil was injected, after the other placebo, using a balanced design and double-blind procedures. A test dose of the lorazepam or oxazepam was administered the day after the flumazenil or placebo. A battery of physiological and psychological tests was applied before and after the dose of benzodiazepine on days 1, 4, 8 and 10. The benzodiazepines had the expected effects on the EEG, and event-related potentials (ERP), impaired several psychological tests and induced drowsiness and relaxation. Some tolerance was seen with respect to anxiolytic effects, some EEG and ERP variables and some psychological tests, but not those of memory. Tolerance tended to be more apparent in the subjects given lorazepam than in the oxazepam-treated subjects. No effects of the small dose of flumazenil in reversing tolerance were apparent.
Alcohol Policy in Canada: Reflections on the Role of the Alcohol Industry

Introduction The alcohol industry has played, and continues to play, a decisive role in alcohol policy issues. Given the importance of alcohol policy in reducing or preventing harm from alcohol (Babor et al. 2003), it is surprising that there have been relatively few studies that have looked at the role of the alcohol industry in policy-making (e.g., Addiction 2000; Greenfield et al. 2004; Ogborne et al. 2006; Giesbrecht et al. 2006a). Policy-makers face many challenges, and these can be highlighted by contrasting the view that emerges from recent alcohol epidemiology and social science with that from alcohol marketing and promotion. In the epidemiological studies such as the WHO Global Burden of Disease Project, the disease, death and disability from alcohol is similar to that from tobacco, and even higher in some developing countries (World Health Organization 2002; Rehm et al. 2003a). Alcohol is a major contributor to unintentional injuries or death, violence including homicide and suicide, and a wide range of chronic diseases (e.g. Bagnardi et al. 2001; Boffetta & Hashibe 2006; Room et al. 2005). While epidemiological literature has shown that alcohol is an important risk factor for acute and chronic damage (e.g. World Health Organization 2002; Haydon et al. 2006),
Lack of Chromatin and Nuclear Fragmentation In Vivo Impairs the Production of Lupus Anti-Nuclear Antibodies1

Nuclear autoantigens in systemic lupus erythematosus are thought to derive primarily from apoptotic cells, yet there is no direct evidence that interfering with apoptosis impairs the generation of lupus autoantibodies. Here we use a mouse model that lacks the endonuclease caspase-activated DNase (CAD), resulting in an absence of chromatin and nuclear fragmentation during apoptotic cell death. We show that in this mouse, production and release into circulation of chromatin is impaired after exposure to several apoptotic triggers, but that the absence of CAD does not interfere with upstream steps of apoptosis or immune system function. Finally we show that in CAD-mutant mice, impaired lupus autoimmunity is skewed toward known cytoplasmic components, and autoimmunity toward membrane autoantigens is preserved, while autoimmunity toward chromatin and other lupus nuclear targets is severely impaired or absent. We also show, as control, that the induction of experimental autoimmune encephalomyelitis is not affected by the absence of CAD. Thus, our work in vivo strongly suggests that apoptotic molecular steps during cell death generate nuclear autoantigens to sustain the specific autoimmune response in systemic lupus erythematosus.