Miracle-dz/UniFAR-FTUs huggingface dataset:
On the meaning of innovation performance : Is the synthetic indicator of the Innovation Union Scoreboard flawed?

The European Union (EU) annually publishes an Innovation Union Scoreboard (IUS) as a tool to measure the innovation performance of EU Member States by means of a composite index, called the Summary Innovation Index (SII). The SII is constituted by an average of 25 indicators. The SII is claimed to rank Member States according to their innovation performance. This means that the higher the average value of the 25 indicators, the better the innovation performance is said to be. The first purpose of this article is to assess whether the SII constitutes a meaningful measure of innovation performance. Our conclusion is that it does not. Our second purpose is to develop alternative, productivity or efficiency-based, measures of innovation system performance based on a simple index number, and complement it with advanced and robust nonparametric Data Envelopment Analysis techniques. By doing so, the article offers a critical review of the SII, and proposes to put more emphasis on the identification of and relation between input and output innovation indicators. The data provided by the 2014 and 2015 editions of the IUS are here used to analyze the innovation performance of all 28 EU national innovation systems. A theoretical background and reasons for selecting the indicators used are presented, and our new ranking of the innovation performance using bias-corrected efficiency scores of all EU countries is calculated. We find that the results differ substantially between the SII and the ranking based on our method, with significant consequences for the design of innovation policies.
Color Opponency in Synaesthetic Experiences

Grapheme-color synaesthesia is a rare condition in which perception of a letter or a digit is associated with concurrent perception of a color. Synaesthetes report that these color experiences are vivid and realistic. We used a Stroop task to show that synaesthetically induced color, like real color, is processed in color-opponent channels (red-green or blue-yellow). Synaesthetic color produced maximal interference with the perception and naming of the real color of a grapheme if the real color was opponent to the synaesthetic color. Interference was reduced considerably if the synaesthetic and real colors engaged different color channels (e.g., synaesthetic blue and real red). No dependence on color opponency was found for semantic conflicts between shape and color (e.g., a blue lemon). Thus, the neural representation of synaesthetic colors closely resembles that of real colors. This suggests involvement of early stages of visual processing in color synaesthesia and explains the vivid and realistic nature of synaesthetic experiences.
Small (< or = 3 cm) renal masses: correlation of spiral CT features and pathologic findings.

OBJECTIVE We describe our 3-year experience using spiral CT in the evaluation of small renal masses in order to determine the usefulness of this technique for classifying the lesions and to correlate specific CT features with pathologic findings. MATERIALS AND METHODS We retrospectively analyzed spiral CT scans and results of pathologic examinations of surgically extirpated small (< or = 3 cm) renal masses in 35 patients. The masses included 27 renal cell carcinomas, two transitional cell carcinomas, one leiomyoma, one angiomyolipoma, and four benign cysts. Several imaging features, including attenuation, pattern of contrast enhancement, presence and type of calcification, cyst wall, and septation, were correlated with pathologic findings. RESULTS Most renal cell carcinomas had a solid growth pattern (n = 19), had attenuation values on unenhanced scans of 20 H or greater (n = 26), and had attenuation values that increased by at least 10 H with contrast enhancement (n = 26). Only three renal cell carcinomas were mostly cystic on pathologic examination. Heterogeneous enhancement correlated with the presence of acellular regions (p = .02). Of 12 cystic masses, spiral CT showed the absence of a thick or nodular fibrous capsule in seven of nine masses (specificity, 0.78) and the absence of several (or nodular) septations in six of seven masses (specificity, 0.86) but was not as sensitive in detecting these features. CONCLUSION Spiral CT can show many of the key imaging features of small renal masses used to distinguish between benign and malignant lesions. However, despite the theoretical benefits of volumetric CT, some lesions remain indeterminate and require surgical removal for diagnosis.
c‐crbB2 gene amplification and protein expression in ovarian epithelial tumors: Evaluation of their respective prognostic significance by multivariate analysis

c‐erbB2 gene amplification or over‐expression has been reported in ovarian cancer, but their prognostic value remains conflicting. To investigate the respective prognostic significance of c‐erbB2 gene amplification and protein over‐expression, tumor samples were obtained from 65 patients with ovarian adenocarcinoma (9 FIGO stage I, 7 stage ll, 38 stage III and 11 stage IV) followed up for a median period of 71 months. c‐erbB2 gene amplification (>2.5 a.u.) was detected in 9/65 (14%) adenocarcinomas and in none of 5 benign and 8 borderline ovarian epithelial tumors also analyzed. Specimens from 52 of the 65 adenocarcinomas were available for immunohistochemi‐cal analysis. c‐erbB2 protein expression was observed in 23/52 (44%) adenocarcinomas. No correlation was found between c‐erbB2 gene copy number and protein expression. There was no correlation of c‐erbB2 gene copy number or protein expression with any of the clinico‐pathological factors analyzed (i.e., GIGO stage, histological type, histological grade and residual tumor). On univariate analysis, c‐erbB2 gene amplification was associated with poorer survival (p = 0.04). However, in the multivariate analysis of clinico‐pathological factors and c‐erbB2 gene copy number, c‐erbB2 gene amplification did not retain any independent prognostic significance (p = 0.19). No significant survival difference was found between patients with and without c‐erbB2 protein over‐expression in univariate or multivariate analyses. Therefore, neither c‐erbB2 gene amplification nor c‐erbB2 protein over‐expression appears to be a significant prognostic marker in patients with ovarian carcinoma. © 1995 Wiley‐Liss, Inc.
A Comparison of the Effects of Reading Interventions on Engagement and Performance for Fourth-Grade Students With Learning Disabilities

Inexpensive software applications designed to teach reading, writing, mathematics, and other academic areas have become increasingly popular. Although previous research has demonstrated the potential efficacy of such applications, there is a paucity of research that compares applications instruction (AI) with traditional teacher-directed instruction (TDI), and the relative effectiveness and efficiency of these instructional approaches remains largely unknown. This study used an alternating treatment design to compare academic engagement and outcomes (i.e., word identification and reading fluency) during an AI condition and a TDI condition for four students with learning disabilities (LD) attending a charter school. Instructional conditions (i.e., TDI, AI) were randomly alternated 7 times each, for a total of 14 instructional sessions. Results indicated that both approaches fostered high levels of engagement although students were more engaged during AI. With regard to academic performance, visual and quantitative analysis suggest that TDI was more effective than AI in terms of passage fluency and word identification. Students completed social validity rating scales to examine instructional preference. Results indicated that both approaches, TDI and AI, were popular with the students.
Application of Wrench-Based Feasibility Analysis to the Online Trajectory Optimization of Legged Robots

Motion planning in multicontact scenarios has recently gathered interest within the legged robotics community, however actuator force/torque limits are rarely considered. We believe that these limits gain paramount importance when the complexity of the terrains to be traversed increases. We build on previous research from the field of robotic grasping to propose two new six-dimensional bounded polytopes named the Actuation Wrench Polytope (AWP) and the Feasible Wrench Polytope (FWP). We define theAWP as the set of all the wrenches that a robot can generate while considering its actuation limits. This considers the admissible contact forces that the robot can generate given its current configuration and actuation capabilities. The Contact Wrench Cone (CWC) instead includes features of the environment such as the contact normal or the friction coefficient. The intersection of the AWP and of the CWC results in a convex polytope, the FWP, which turns out to be more descriptive of the real robot capabilities than existing simplified models, while maintaining the same compact representation. We explain how to efficiently compute the vertex-description of the FWP that is then used to evaluate a feasibility factor that we adapted from the field of robotic grasping. This allows us to optimize for robustness to external disturbance wrenches. Based on this, we present an implementation of a motion planner for our quadruped robot HyQ that provides online Center of Mass trajectories that are guaranteed to be statically stable and actuation-consistent.
Effect of Auditory Evoked Potential-Guided Anaesthesia on Consumption of Anaesthetics and Early Postoperative Cognitive Dysfunction: a randomised controlled trial

Background Post-operative cognitive dysfunction (POCD) after non-cardiac surgery is a well known problem in some categories of patients. This study aims to evaluate the influence of auditory evoked potential (AEP)-guided anaesthesia on the requirement for anaesthetic drugs and their influence on POCD. Methods Four hundred and fifty patients aged between 18 and 92 years scheduled for ophthalmic surgery under general anaesthesia were assigned randomly to one of two groups. In group A (AEP group), the depth of anaesthesia (DoA) was aimed at an AEP index (AAI) between 15 and 25. In group C (control group), DoA was guided by clinical signs. Hypotension was treated with fluids and vasopressors using a standardised algorithm. A mini-mental test and the Cognitive Failure Questionnaire were used to evaluate cognitive function. Results Anaesthetic drug requirements were significantly lower in group A than in group C: propofol 92.5 ± 26.5 vs. 103.8 ± 39.5 mg (P = <0.001) and desflurane end-tidal concentration 2.5 ± 0.58 vs. 3.3 ± 0.79% (P < 0.001). In group A, 36 patients (16%) received additional fluids and vasopressors compared to 65 patients (29%) in group C (P < 0.01). AAI values differed significantly between the groups: 18 (11–21) in group A vs. 12 (10–19) in group C (P < 0.001). The number of patients with POCD was 16 in group C compared to two in group A (P < 0.001) at day 1 post-operation. Conclusion AEP monitoring allows dose reduction of anaesthetic agents, leading to better cardiovascular stability and decreased requirements for intra-operative fluids and vasopressors. Cognitive decline seen following minor ophthalmic surgery, even when anaesthesia is assessed clinically, is short-lived with no long-term sequelae.
More than goods: trade in welfare through foods

This paper examines the impact of trade openness over child and general population food security in Latin American countries, except for Haiti, Cuba and the Small Caribbean States, between 1985 and 2016. In order to do so, we regress 5 trade indicators over 6 food security indicators using a FE panel data model and controlling for macroeconomic situation and the number of food security programmes implemented by each country in each year. Our results suggest that there is a strong influence of trade over the reduction of undernutrition in its different forms, improving food security in Latin America. Imports have improved weightfor- height and height-for-age indicators due to improvements in food availability, both in nutritional variety and quality. This suggests a stabilization of seasonal fluctuations in food access and consequent prevalence of infectious diseases. On the other hand, exports seemed to have produced an income effect, which in turn has enabled the reduction of extreme forms of undernutrition and allowed for the purchase of more nutritious food.
Active Harmonic Reduction Using DC-Side Current Injection Applied in a Novel Large Current Rectifier Based on Fork-Connected Autotransformer

In this paper, a novel large current rectifier using the fork-connected autotransformer and dc-side current injection method is proposed. The fork-connected autotransformer outputs two sets of three-phase voltages with 60° phase difference, and feeds two three-phase half-wave rectifiers. Compared with the isolated line-frequency transformer, the proposed autotransformer has lower kilovoltampere (kVA) rating under the same load power. An optimal designed single-phase full-bridge inverter is used to inject the compensation currents into the dc side of the two three-phase half-wave rectifier, which can reduce the harmonics in input line current to be an acceptable level. The kVA rating of the single-phase full-bridge inverter is very lower, and the proposed large current rectifier draws nearly sinusoidal currents from the ac main after using the dc-side injection. A 4 kW prototype is set up to validate the theoretical analysis and evaluate the performance.
Synthesis and characterization of hydroxyapatite-ciprofloxacin delivery systems by precipitation and spray drying technique

This investigation synthesized and characterized hydroxyapatite (HAP) microspheres, agglomerated microspheres, and implants containing ciprofloxacin. This delivery system is to be used as an implantable drug delivery system for the treatment of bone infections. The HAP microspheres were made by chemical precipitation followed by a spray-drying technique. Agglomerated microspheres were prepared by a wet granulation process using a granulator. Implants were prepared by direct compression of the granules on a Carver press. Ciprofloxacin was analyzed by high-performance liquid chromatography. Characterization of the HAP microspheres include particle size, size distribution, physical state of the drug in the microsphere, and microstructure of the drug delivery system before and after in vitro release. The particle size, porosity, and morphology of the microspheres were dependent on viscosity and concentration of the slurry as well as the atomization pressure used during spray drying. Even at the highest drug load (2% wt/wt), the drug was present in a noncrystalline state. The drug release from the agglomerated microspheres was quick and almost complete within 1 hour. However, compressing the same amount of agglomerated microspheres into an implant greatly reduced the rate of ciprofloxacin release. Only 12% (wt/wt) of the drug was released from the implant within 1 hour.The in vitro release of ciprofloxacin from these implants follows a diffusion-controlled mechanism. This method provides a unique way of producing various shapes and drug loads of HAP microspheres that can be easily manufactured on a commercial scale.
Preservice Agricultural Education Teachers and Secondary Education Teachers’ Self-Efficacy and Professional Identity

During the nineteenth century, a decision was made to separate the preparation of agricultural education teachers from their elementary and secondary counterparts (Hearings, 1908; Heren & Hillison, 1996; Hillison, 1986). The majority of land-grant universities and colleges have continued to prepare agricultural education preservice teachers within the college of agriculture, separate from other secondary education preservice teachers in the college of education (Myers & Dyer, 2004). Despite the differences among content disciplines, teachers who possess a strong sense of self-efficacy and professional identity have higher success rates in the classroom when it comes to collaboration, involvement, and student achievement (Ashton & Webb, 1986; Bandura, 1997; Dembo & Gibson, 1985; O’Bryant, 1992; Putman, 2012; Skaalvik & Skaalvik, 2008; Tschannen-Moran & Woolfolk Hoy, 2001White, 2009; Woolfolk, Rosoff, & Hoy, 1990). Therefore, the purpose of this study was to describe the self-efficacy and professional identity of preservice agricultural education teachers and other secondary education preservice teachers. Data were collected from land-grant universities and colleges through either electronic or paper surveys. Respondents (N = 85) from 13 institutions included both agricultural education preservice teachers (n = 68) and other secondary education preservice teachers (n = 17). The instrument used in this study was a modified questionnaire that combined two previously established scales, Tschannen-Moran and Woolfolk Hoy’s (2001) Teacher’s Sense of Efficacy Scale and Woo’s (2013) Professional Identity Scale in Counseling. Descriptive statistics revealed that agricultural education preservice teachers’ possessed a slightly higher level of self-efficacy than other secondary education preservice teachers. Conversely, secondary education preservice teachers possessed a slightly higher level of professional identity than agricultural education preservice teachers. A Pearson’s Correlation was used to reveal a negligible relationship between self-efficacy and professional identity among agricultural education preservice teachers. However, there was a small relationship between self-efficacy and professional identity among secondary education preservice teachers. Further research should be conducted to establish the development of self-efficacy and professional identity throughout the teacher career cycle through longitudinal studies. Additionally, the literature suggest a relationship between selfefficacy and professional identity, but more research is recommended to empirically prove and generalize this to all preservice teachers.
Time-Consistency of Optimal Investment under Smooth Ambiguity

We study portfolio choice in a Black-Scholes world under drift uncertainty. Preferences towards risk and ambiguity are modeled using the smooth ambiguity approach under a double power utility assumption and a normal distribution assumption on the unknown drift. Optimal investment in this setting is time-inconsistent: While utility is maximized by a precommitment strategy resembling the classical Merton solution, the investor’s future selves prefer to constantly increase the riskiness of the strategy. In contrast, the optimal dynamically consistent investment strategy accounts for variations in the perceived severity of drift uncertainty, thus increasing the riskiness of the strategy gradually over time. We provide a detailed comparative analysis of the mechanics and interplay of ambiguity, myopia and optimal decisions in this setting. We show that an investor who pre-commits will regret that decision from some time point onwards, wishing that she had followed the dynamically consistent strategy. This “point of regret” always lies near the middle of the investment horizon.
WHICH CRITERIA ARE CONSIDERED IN HEALTHCARE DECISIONS? INSIGHTS FROM AN INTERNATIONAL SURVEY OF POLICY AND CLINICAL DECISION MAKERS

Objectives: The aim of this study was to gather qualitative and quantitative data on criteria considered by healthcare decision makers. Methods: Using snowball sampling and an online questionnaire with forty-three criteria organized into ten clusters, decision makers were invited by an international task force to report which criteria they consider when making decisions on healthcare interventions in their context. Respondents reported whether each criterion is “currently considered,” “should be considered,” and its relative weight (scale 0–5). Differences in proportions of respondents were explored with inferential statistics across levels of decision (micro, meso, macro), decision maker perspectives, and world regions. Results: A total of 140 decision makers (1/3 clinical, 2/3 policy) from 23 countries in five continents completed the survey. The most relevant criteria (top ranked for “Currently considered,” “Should be considered,” and weights) were Clinical efficacy/effectiveness, Safety, Quality of evidence, Disease severity, and Impact on healthcare costs. Organizational and skill requirements were frequently considered but had relatively low weights. For almost all criteria, a higher proportion of decision makers reported that they “Should be considered” than that they are “Currently considered” (p < .05). For more than 74 percent of criteria, there were no statistical differences in proportions across levels of decision, perspectives and world regions. Statistically significant differences across several comparisons were found for: Population priorities, Stakeholder pressure/interests, Capacity to stimulate research, Impact on partnership and collaboration, and Environmental impact. Conclusions: Results suggest convergence among decision makers on the relevance of a core set of criteria and on the need to consider a wider range of criteria. Areas of divergence appear to be principally related to contextual factors.
Effects of Miglyol 812 on Rats After 4 Weeks of Gavage as Compared with Methylcellulose/Tween 80

Miglyol 812 is a medium-chain triglyceride used in toxicology studies as an excipient to improve test compound solubility/absorption. As part of a larger toxicology study, 15 Wistar Han IGS rats/sex/group were dosed by oral gavage for 4 weeks with 10 mL kg− 1 day− 1 of 100% Miglyol 812 or 0.5% methylcellulose/0.1% Tween 80 in water (MC-T) followed by 4 weeks without treatment to evaluate the potential effects of this excipient in long-term toxicology studies relative to a traditional excipient such as MC-T. Clinical signs evident during the dosing phase included soft and/or mucoid stool in 12/15 males and 11/15 females treated with Miglyol 812 but in no animals treated with MC-T. Animals treated with Miglyol 812 had a 6–7% statistically significant reduction in body weight gain as compared to MC-T–treated animals. Statistically significant changes in clinical chemistry parameters as compared to MC-T included decreased blood urea nitrogen (50% and 29% in males and females, respectively), increased cholesterol (1.6-fold and 1.5-fold in males and females, respectively), decreased total protein (6% and 8% in males and females, respectively), decreased globulins (15% and 11% in males and females, respectively), and increased triglycerides (2.8-fold and 1.7-fold in males and females, respectively). Absolute and relative thymic weights decreased 28% and 24%, respectively, in males, and 18% and 17%, respectively, in females without histological alterations. Histopathology revealed increased alveolar histiocytosis with focal interstitial inflammation in lungs in 5/10 males and 7/10 females treated with Miglyol 812 compared to only 1/10 males and 1/10 females treated with MC-T. All effects were reversible during the recovery period. Results of this study indicate that 100% miglyol 812 produces reversible gastrointestinal effects and decreases in body weight gains along with changes in several serum chemistry parameters. Therefore, it should not be considered innocuous when delivered by oral gavage in long-term rodent toxicology studies.