Miracle-dz/UniFAR-FTUs huggingface dataset:
Load balancing for multiple traffic matrices using SDN hybrid routing

Classical traffic engineering (TE) methods calculate the optimal routing based on a single traffic matrix. However, they are unable to handle unexpected traffic changes. Thus, it is of interest to find a good routing configuration to accommodate multiple possible traffic scenarios. There are two major approaches to achieve load balancing for multiple traffic matrices: destination-based routing and explicit routing. It has been shown that explicit routing performs better than destination-based routing for multiple traffic matrices. However, explicit routing has high complexity and requires large Ternary Content Addressable Memory (TCAM) in the routers. Thus, it is power hungry and unscalable. This paper presents an approach called hybrid routing to achieve load balancing for multiple traffic matrices with low complexity and good scalability. Our basic idea is to complement destination-based routing with a small number of explicit routing forwarding entries to take advantage of both two routing approaches. Hybrid routing greatly reduces the number of forwarding entries compared with pure explicit routing. This has great value for practice in that the scheme requires very small TCAM to implement. Hybrid routing is very suitable for implementation using SDN. A heuristic algorithm is developed to obtain the near-optimal hybrid routing configuration. Extensive evaluation demonstrates the effectiveness of hybrid routing. The results show that hybrid routing achieves near-optimal load balancing compared with pure explicit routing. In particular, hybrid routing saves at least 84.6% TCAM resources in all practical networks used in our evaluation.
Purification of Drosophila melanogaster Ultraspiracle Protein and Analysis of Its A/B Region-Dependent Dimerization Behavior in vitro

Abstract Two members of the nuclear receptor superfamily, EcR (ecdysteroid receptor protein) and Usp (Ultraspiracle), heterodimerize to form a functional receptor for the steroid hormone 20-hydroxyecdysone and thus enable it to coordinate morphogenetic events during insect metamorphosis. Nterminally Histagged Usp was overexpressed in E. coli cells as a nontruncated protein and purified to homogeneity in two chromatographic steps. It was demonstrated that the recombinant receptor specifically binds the ecdysone response element of the hsp27 gene promoter (hsp27EcRE). Moreover, ahighly synergistically formed heterodimeric complex with the DNA-binding domain of EcR was observed on hsp27EcRE, but not on the native Usp response element from the chorion s15 gene promoter. Recombinant Usp forms homodimers and homotetramers in the absence of DNA, as judged from gel filtration and chemical crosslinking experiments. Truncation of its N-terminal A/B region changes molecular characteristics of Usp, considerably weakening its oligomerization potential under the same experimental conditions. This contrasts with the results obtained previously for the similarly truncated RXR – a vertebrate homolog of Usp.
Spectrophotometric determination of complex formation equilibria of copper ( II ) , metformin and halides in methanol

Metformin is prescribed against Diabetes Mellitus II, nevertheless its mechanisms of action are not fully understood. Several studies suggest that mitochondrial copper is chelated by metformin and the properties of the copper-metformin complex could generate the therapeutic activity. In this work, a spectrophotometric study was performed in order to evaluate in methanol, the stability of the species coppermetformin and copper-metformin-halides. The formation constants and the calculated electronic spectrum of each species at 298 K, are reported. According with our results and considering the mitochondrial chloride concentration reported elsewhere, we hope that these data can be correlated with possible implications in vivo.
Severe and fatal complications after diagnostic and therapeutic ERCP: a prospective series of claims to insurance covering public hospitals.

BACKGROUND AND STUDY AIMS Increasing numbers of patients are undergoing endoscopic retrograde cholangiopancreatography (ERCP) prior to laparoscopic cholecystectomy, and more departments and doctors are performing ERCP, while new data from large prospective series have documented the risks of both diagnostic and therapeutic ERCP. The establishment in Denmark of a Patient Insurance Association, which has covered injury caused during investigation and treatment in public hospitals since July 1992, has made it possible to collect and analyze a large prospective series of ERCP complications for which compensation has been claimed. PATIENTS AND METHODS Thirty-nine consecutive claims for compensation due to complications after ERCP occurring between 1 July 1992 and 31 December 1996 were investigated. Case notes were reviewed, along with laboratory reports and radiographs. The complications were classified according to the international consensus. RESULTS Claims for compensation were made in 39 cases from 25 hospitals. The indication for ERCP was appropriate in 31. Precut papillotomy for access had been performed in seven. The severity of the complications was mild in one patient, moderate in three patients, severe in 24, and fatal in nine; in two cases, the severity was not classifiable. The complications were: pancreatitis in 23 patients (seven cases fatal, one of which had involved a precut procedure), bleeding in two, perforation in nine (six had a precut procedure, one died), and other reasons in five (including one fatal case). Among the nine fatal cases, cannulation had not been achieved in two and the endoscopic retrograde cholangiogram was normal in four, one of whom underwent a sphincterotomy. One patient with a previous adenoma had an endoprosthesis removed, developed gangrenous cholecystitis afterward, and died. Thirty patients were eligible for compensation. The rejected cases included mild and moderate pancreatitis, a case of fatal hemorrhagic pancreatitis in which the patient had refused blood transfusion, and one patient who had pancreatitis prior to ERCP. CONCLUSIONS ERCP, even for diagnostic purposes, may be associated with very serious and even fatal complications. The use of the precut procedure for access should still be considered dangerous. Other means of investigating the bile ducts should be developed. If endoscopic ultrasonography and magnetic resonance cholangiography prove to have the same diagnostic value as ERCP, which must be considered the gold standard for visualizing the ducts today, they might replace ERCP as the primary investigation in patients with an intermediate or low risk of bile duct stones; this would reduce the numbers of patients exposed to the risks of ERCP.
Biological Enhancement of Meniscus Repair and Replacement

When a meniscus injury occurs, it is generally accepted that preserving the meniscus is important for life-long joint preservation. Traditional suture repair of the meniscus has good results; however, the healing potential of meniscus tissue remains as a biological challenge because it is not a completely vascularized structure. For this reason, investigators have continued to search for adjuncts to improve clinical results. Mechanical adjuncts, local factor enhancement, scaffolds, gene therapy, and cell therapy have all been examined as options for improvement of biology and structure. This study reviews the basic science and clinical application of these modalities and provides an assessment of techniques on the horizon.
Distribution and localization of Epstein–Barr virus subtypes A and B in AIDS‐related lymphomas and lymphatic tissue of HIV‐positive patients

Tissue samples of 421 HIV‐positive patients have been studied for the presence and distribution of Epstein–Barr virus (EBV) subtypes A and B. This was done by PCR, EBER in situ hybridization, and immunohistochemical detection of EBV latent membrane protein (LMP) in AIDS‐associated malignant lymphomas (16 cases) and lymphatic organs of patients without lymphoma (5 cases). Eleven cases were considered to be EBV‐positive, with type A in four, and type B virus in four other cases. In patients with malignant lymphoma, EBV was localized in tumour tissue exclusively. One patient without lymphoma presented with multiple EBV genome type B‐positive cells in all the lymphoid tissue samples examined. In HIV‐positive patients, both subtypes of EBV, A and B, may play a role in the pathogenesis of lymphoproliferative lesions.
Mode in output participation factors for linear systems

The common definition of modal participation factors was intended to provide a measure of participation of modes in states and of states in modes for linear time-invariant (LTI) systems. In this paper, recent work by the authors that revisited this common definition is extended to yield definitions and calculations for quantifying the relative contribution of system modes in system outputs. When the system outputs are simply the system states, the mode-in-output participation factors are found to reduce to the original mode-in-state participation factors. A numerical example is given to illustrate the issues addressed and the results obtained.
Modification of humoral responses by the combination of leflunomide and cyclosporine in Lewis rats transplanted with hamster hearts.

BACKGROUND Vigorous antibody-mediated responses prevent the successful engraftment of hamster hearts transplanted into Lewis rats. Early antibody responses mediating acute rejection of the xenograft are T cell-independent and resistant to the T-cell immunosuppressant, cyclosporine (CsA). Immunosuppression with the combination of leflunomide plus CsA completely prevents xenograft rejection, but when such immunosuppression is stopped the hamster heart is rejected by a process that we term late xenograft rejection. We report here on some of the immunological features of late xenograft rejection. METHODS Lewis rats transplanted with hamster hearts were treated with leflunomide (5 mg/kg/day by gavage) for 14-21 days and CsA (20 mg/kg/day by gavage) continuously from the day of transplant. Serum was harvested and the functional activities of the xenoreactive antibodies were quantitated by in vivo passive transfer of sera, flow cytometry, in vitro C3 deposition assays, and Western blotting. RESULTS CsA alone prevented late xenograft rejection and the accompanying production of xenoreactive antibodies. The xenoreactive antibodies accompanying acute or late xenograft rejection were predominantly IgM, but only serum from rats undergoing acute xenograft rejection was able to induce hyperacute rejection. The ability of serum to induce hyperacute rejection correlated with its ability to induce C3 deposition on hamster lymphocytes in vitro. The repertoire of hamster antigens recognized by IgM in the serum of rats undergoing late xenograft rejection is more restricted than that of IgM in the serum of rats undergoing acute xenograft rejection. We additionally demonstrate that long-term graft survival is not dependent on graft accommodation. CONCLUSIONS These studies demonstrate that a brief treatment with the combination of leflunomide and CsA profoundly modifies the humoral xenoreactivity in the recipient, converting it from a T-independent into a T cell-dependent response. Differences in functional activity of sera from acute or late xenograft rejection suggest that antigenic specificity defines the ability of IgM to induce complement activation and hyperacute rejection.
Student Academic Achievement in Charter Schools: What We Know and Why We Know So Little. Occasional Paper No. 41.

Student achievement is central to the policy debate over charter schools. This paper reviews what is currently known about charter schools' impact on student achievement. After documenting the dearth of systematic empirical studies on the topic, the paper combines the findings of existing research into an overall impact rating, weighted by the studies' methodological quality. It finds that the existing body of research reveals a mixed picture, with studies from some states suggesting a positive impact, studies from other states suggesting a negative impact, and some providing evidence of positive and negative impacts. Overall, the charter impact on student achievement appears to be mixed or very slightly positive. However, this conclusion is tempered by the fact that there are, as yet, no systematic studies of charter achievement in several states that have large numbers of charter schools. The paper concludes by offering some preliminary explanations for variations in charter performance across states and for the paucity of empirical evidence in many states. (Contains 48 references.) (Author/SM) Reproductions supplied by EDRS are the best that can be made from the original document. Occasional Paper No. 41 National Center for the Study of Privatization in Education Teachers College, Columbia University Student Academic Achievement in Charter Schools: What We Know and Why We Know So Little ' Gary Miron and Christopher Nelson The Evaluation Center 401B Ellsworth Hall Western Michigan University Kalamazoo, MI 49008-5237 December 2001 U.S. DEPARTMENT OF EDUCATION Office of Educational Research and Improvement EDUCATIONAL RESOURCES INFORMATION ))tif CENTER (ERIC) This document has been reproduced as received from the person or organization originating it. Minor changes have been made to improve reproduction quality. Points of view or opinions stated in this document do not necessarily represent official OERI position or policy. PERMISSION TO REPRODUCE AND DISSEMINATE THIS MATERIAL HAS BEEN GRANTED BY
Extrahepatic Portal Vein Obstruction

Extrahepatic portal vein obstruction (EHPVO) is an important cause of noncirrhotic portal hypertension, especially in Third World countries. The etiology and clinical presentation are different in children and adults. The portal vein is transformed into a cavernoma, resulting in portal hypertension and oesophagogastic varices. In addition, extensive collateral circulation develops, involving paracholecystic, paracholedochal and pancreaticoduodenal veins resulting in formation of ectopic varices, and portal biliopathy. Besides variceal bleeding, which is the commonest presentation, patients may have symptomatic portal biliopathy, hypersplenism, and growth retardation. Although the liver may appear normal, functional compromise develops in the long term. Variceal bleeding in EHPVO can be successfully managed by endoscopic obliteration of varices, which has low morbidity but requires repeated visits, or by portosystemic shunt surgery, which provides good control of bleeding, possibly helps growth retardation, hypersplenism, and protects against future development of portal biliopathy but is associated with surgical mortality and is sometimes not feasible due to nonavailability of a satisfactory vessel.
Design and Evaluation of a Public Installation of an Eye-Gaze System

ABSTRACT This article evaluates an eye-tracking device (“I Can Speak With My Eyes”) designed for a museum exhibition. An eye-tracking system is designed not only for able individuals, but also for bedridden patients or physically handicapped people who intend to use computers. With one video CCD camera and frame grabber analyzing a series of images taken of the human pupil gazing at a screen, an auto-range-finding algorithm can be used to obtain the location of the pupil in real time. The computers will produce speech according to the location of where the eyes are gazing. In essence, the participants can speak with their eyes to achieve the advantages of learning and communicating. After the system was implemented, an experimental evaluation with innovation diffusion theory was conducted to survey users’ feelings regarding the system. The implications of the evaluation findings are discussed to aid further research and education.
Oregovomab maintenance monoimmunotherapy does not improve outcomes in advanced ovarian cancer.

PURPOSE This phase III study tested the hypothesis that the CA-125-specific murine monoclonal antibody, oregovomab, administered as a monoimmunotherapy after front-line therapy in a selected ovarian cancer population would prolong time to relapse (TTR) and, ultimately, survival. PATIENTS AND METHODS Patients with stage III to IV ovarian cancer with preoperatively elevated CA-125 and objectively defined characteristics were randomly assigned 4 to 12 weeks after front-line carboplatin and paclitaxel chemotherapy to maintenance monoimmunotherapy in a fully blinded protocol. Two mg of oregovomab or placebo was infused over 20 minutes at weeks 0, 4, and 8 and then 12 weeks until recurrence or up to year 5. Patients were evaluated with serial imaging and clinical evaluation for evidence of recurrence at quarterly visits. TTR was the primary end point. RESULTS Three hundred seventy-three patients were accrued at more than 60 centers; 251 patients were assigned to oregovomab and 120 patients were assigned to placebo. The treatment arms were well balanced. There were no differences in the clinical outcomes between treatment groups. Median TTR measured from randomization after completion of chemotherapy for the integrated study was 10.3 months (95% CI, 9.7 to 13.0 months) for oregovomab and 12.9 months (95% CI, 10.1 to 17.4 months) for placebo (P = .29, log-rank test). The treatment was well tolerated. Grade 3 to 4 toxicity was reported in 24.6% of patients in the placebo group and 20.1% of patients in the oregovomab group, respectively. CONCLUSION Although oregovomab has demonstrated bioactivity, the strategy of monoimmunotherapy is not effective as maintenance therapy after front-line treatment of a favorable subset of patients with advanced ovarian cancer. Future studies of this or other tumor-antigen specific immunization strategies should seek ways to further augment induced immunity.
Positive crosstalk between arginase‐II and S6K1 in vascular endothelial inflammation and aging

Augmented activities of both arginase and S6K1 are involved in endothelial dysfunction in aging. This study was to investigate whether or not there is a crosstalk between arginase and S6K1 in endothelial inflammation and aging in senescent human umbilical vein endothelial cells and in aging mouse models. We show increased arginase‐II (Arg‐II) expression/activity in senescent endothelial cells. Silencing Arg‐II in senescent cells suppresses eNOS‐uncoupling, several senescence markers such as senescence‐associated‐β‐galactosidase activity, p53‐S15, p21, and expression of vascular adhesion molecule‐1 (VCAM1) and intercellular adhesion molecule‐1 (ICAM1). Conversely, overexpressing Arg‐II in nonsenescent cells promotes eNOS‐uncoupling, endothelial senescence, and enhances VCAM1/ICAM1 levels and monocyte adhesion, which are inhibited by co‐expressing superoxide dismutase‐1. Moreover, overexpressing S6K1 in nonsenescent cells increases, whereas silencing S6K1 in senescent cells decreases Arg‐II gene expression/activity through regulation of Arg‐II mRNA stability. Furthermore, S6K1 overexpression exerts the same effects as Arg‐II on endothelial senescence and inflammation responses, which are prevented by silencing Arg‐II, demonstrating a role of Arg‐II as the mediator of S6K1‐induced endothelial aging. Interestingly, mice that are deficient in Arg‐II gene (Arg‐II−/−) are not only protected from age‐associated increase in Arg‐II, VCAM1/ICAM1, aging markers, and eNOS‐uncoupling in the aortas but also reveal a decrease in S6K1 activity. Similarly, silencing Arg‐II in senescent cells decreases S6K1 activity, demonstrating that Arg‐II also stimulates S6K1 in aging. Our study reveals a novel mechanism of mutual positive regulation between S6K1 and Arg‐II in endothelial inflammation and aging. Targeting S6K1 and/or Arg‐II may decelerate vascular aging and age‐associated cardiovascular disease development.
PROSPECTS FOR MEASURING NEUTRON-STAR MASSES AND RADII WITH X-RAY PULSE PROFILE MODELING

Modeling the amplitudes and shapes of the X-ray pulsations observed from hot, rotating neutron stars provides a direct method for measuring neutron-star properties. This technique constitutes an important part of the science case for the forthcoming NICER and proposed LOFT X-ray missions. In this paper, we determine the number of distinct observables that can be derived from pulse profile modeling and show that using only bolometric pulse profiles is insufficient for breaking the degeneracy between inferred neutron-star radius and mass. However, we also show that for moderately spinning (300–800 Hz) neutron stars, analysis of pulse profiles in two different energy bands provides additional constraints that allow a unique determination of the neutron-star properties. Using the fractional amplitudes of the fundamental and the second harmonic of the pulse profile in addition to the amplitude and phase difference of the spectral color oscillations, we quantify the signal-to-noise ratio necessary to achieve a specified measurement precision for neutron star radius. We find that accumulating 106 counts in a pulse profile is sufficient to achieve a ≲ 5% uncertainty in the neutron star radius, which is the level of accuracy required to determine the equation of state of neutron-star matter. Finally, we formally derive the background limits that can be tolerated in the measurements of the various pulsation amplitudes as a function of the system parameters.
Stem cells and myocardial regeneration.

A remarkable paradigm shift is occurring in our understanding of organ regeneration that may have significant therapeutic implications. Conventionally, the heart is perceived as a terminally differentiated organ incapable of regeneration. It is thought that the myocytes respond to physiologic or pathologic stress only by hypertrophy, but not by increase in number. However, recent evidence suggests that adult myocytes may have the ability, albeit limited, to divide and increase in number under certain circumstances. This iconoclastic message has opened the doors for experimentation to increase myocyte number as a strategy to combat cardiac disorders. Simultaneously, experience is accumulating on several aspects of cell transplantation in animal experiments. Historically, various cell types including embryonic, fetal, and neonatal rodent and porcine cardiomyocytes, fetal smooth muscle cells, AT-1 tumor cardiomyocytes, adult and fetal human cardiomyocytes, adult atrial cells, and dermal fibroblasts have been used to augment declining myocyte function. More recently, the focus is on using autologous skeletal myoblasts and bone marrow (BM)-derived stem cells. In this editorial, we briefly review the nascent field of stem cell therapy in cardiac disease.
An electronic decision support system to motivate people with severe mental illnesses to quit smoking.

OBJECTIVE Rates of cigarette smoking are high among people with severe mental illnesses compared with the general population (45%-90% versus 20%). The authors developed a Web-based computer decision support system that is tailored for use by people with cognitive deficits and is designed to stimulate motivation to quit smoking by using evidence-based treatment. METHODS This initial study used a quasi-experimental design to test the decision support system among a convenience sample of 41 smokers with severe mental illnesses. Researchers interviewed participants at baseline and two months later to assess for behaviors indicative of motivation to quit smoking. A negative binomial regression modeled the outcome and controlled for baseline group differences. RESULTS Participants who used the decision support system were significantly more likely to show any behavioral motivation to quit smoking (such as meet with a clinician to discuss cessation, initiate cessation treatment, or otherwise attempt to quit) (67% versus 35%; χ(2)=4.11, df=41, p=. 04). Further, using the decision support system increased by a factor of 2.97, or about 300%, the expected number of ways that a participant showed motivation. CONCLUSIONS The encouraging results of this pilot study indicate that electronic decision supports may facilitate motivation to quit smoking and use of cessation treatment among people with severe mental illnesses.