Miracle-dz/UniFAR-FTUs huggingface dataset:
Cell expansion not cell differentiation predominantly co-ordinates veins and stomata within and among herbs and woody angiosperms grown under sun and shade.

BACKGROUND AND AIMS It has been proposed that modification of leaf size, driven by epidermal cell size, balances leaf water supply (determined by veins) with transpirational demand (generated by stomata) during acclimation to local irradiance. We aimed to determine whether this is a general pattern among plant species with contrasting growth habits. METHODS We compared observed relationships between leaf minor vein density, stomatal density, epidermal cell size and leaf size in four pairs of herbs and woody species from the same families grown under sun and shade conditions with modelled relationships assuming vein and stomatal densities respond passively to epidermal cell expansion. Leaf lignin content was also quantified to assess whether construction costs of herbaceous leaf veins differ from those of woody plants and the leaf mass fraction invested in veins. KEY RESULTS Modelled relationships accurately described observed relationships, indicating that in all species, co-ordinated changes to the density of minor veins and stomata were mediated by a common relationship between epidermal cell size, vein density and stomatal density, with little or no impact from stomatal index. This co-ordination was independent of changes in leaf size and is likely to be an adaptive process driven by the significant proportion of biomass invested in veins (13·1 % of sun leaf dry weight and 21·7 % of shade leaf dry weight). Relative costs of venation increased in the shade, intensifying selective pressure towards economizing investment in vein density. CONCLUSIONS Modulation of epidermal cell size appears to be a general mechanism among our experimental species to maintain a constant ratio between leaf anatomical traits that control leaf water fluxes independently of habit. We propose that this process may co-ordinate plasticity in hydraulic supply and demand in the majority of eudicot angiosperms.
the national society journals present selected research that has driven recent advances in clinical cardiology

The rapid translation from bench to bedside that has been seen in the application of regenerative medicine to cardiology has led to exciting new advances in our understanding of some of the fundamental mechanisms related to human biology. The first generation of cells used in phase I-II trials (mainly bone marrow mononuclear cells) are now entering phase III clinical trials with the goal of producing a cell based therapeutic that can change the outcome of cardiac disease. First generation cell therapy appears to have addressed safety concerns as well as showing ‘activity’ in numerous published metaanalyses. With the knowledge gained to date, the field is moving towards the next generation of cells-the ‘engineered’ cell-that have been developed to display a phenotype that will further enhance the myocardial repair/salvage process. This almanac review covers the latest basic research that may soon have application to humans as well as the results of the latest
Prostasin gene polymorphism at rs12597511 is associated with severe preeclampsia in Chinese Han women

Background Preeclampsia, characterized by hypertension and proteinuria, is a multifactorial disease associated with shallow invasion of trophoblast cells and inadequate spiral artery remodeling. Trophoblast and tumor cells have similar invasion mechanism. Prostasin is closely related to tumor development, invasion and metastasis and influences blood pressure through activating epithelial sodium channel. The effect of prostasin on the pathogenesis of preeclampsia remains unclear. This study investigated the association of prostasin gene at rs12597511 with severe preeclampsia. Methods A single nucleotide polymorphism, rs12597511, was tested with polymerase chain reaction and restriction‐fragment length polymorphism analyses in 179 severe preeclampsia patients and 222 normal pregnant women. Results The frequencies of TC + CC genotypes were significantly higher in severe preeclampsia group compared with in control group (the adjusted odds ratio was 2.030, 95% confidence interval 1.195–3.449, P=0.009). The C allele of rs12597511 was present significantly more often among women with severe preeclampsia (P=0.001). Genotyping analysis showed that the C allele of rs12597511 could confer a risk for severe preeclampsia. Conclusion The higher frequency of C allele of prostasin gene at rs12597511 is associated with severe preeclampsia.
Some stability analysis of a non-linear time-delayed feedback circuit

A key focus of this paper is on understanding stability in a non-linear circuit design subject to delayed feedback. The system we consider is an autonomous first order RC circuit, coupled with a non-linear element, with a fixed feedback delay. With time delays, stability is a key concern. So for the non-linear circuit model we first establish a sufficient condition for local stability. We then establish necessary and sufficient conditions for local stability. Additionally we also exhibit that when local stability is just lost, a Hopf type bifurcation would occur. For the non-linear system, this bifurcation signifies the emergence of limit cycles which can degrade performance. Practically, it is useful to obtain an estimate of the amplitude and frequency of the bifurcating periodic solutions. Such estimates are calculated using the method of harmonic balance. In addition to the local stability analysis, we also establish some global stability results and some conditions to ensure that the solutions of the governing non-linear system are bounded. Some of the theoretical insights obtained are complemented with numerical simulations and also with experiments which are carried out using off-the-shelf components. The combination of theory, both local and global, simulations and experiments serve to enhance our understanding of the underlying model.
Suicide prevalence in Kosova for the period 2007-2008.

UNLABELLED Kosovo as a newer state, characterized with political, economical and cultural transition is touched by suicide phenomenon. Aim of this survey is to analyze prevalence of suicide in Kosova for period 2000-2008 and in particular for 2007-2008. METHODOLOGY Survey is retrospective one and data were taken from Statistical Office of Kosova and Kosovar Police Service report. Cases are analysed due to demographic characteristics as sex, age group, years, dwelling place, months, week days and methods of suicides. RESULTS After the war there is an increase of suicides as it is presented with basic index. For year 2000, there is an increase of 122% compared with cases on 1983, then the highest increase is for 2001 with 711.1%. After 2005 there is a slight decrease of suicides with trend of y = 58-8X. Due to sex, suicides are significantly higher at males than females for both years, with 78.9% for 2007 and 74.5% for 2008. The highest number of suicides is found at age groups 21-30 and 31-40 years with 21.1% for 2007 and 21-30 and 41-50 years with 25.5% for 2008. Average age for suicide victims is 42 years for 2007 and 44 years for 2008. Suicides are more frequent at rural places but not significantly. Greatest percentage of suicides was on July with 21.1% for 2007 and June and October with 15.7% for 2008. On 2007 the highest percentage of suicides was on Wednesdays with 21.1% and on 2008 was on Tuesdays with 19.6%. Due to the time of day, the most frequent time for suicides was 16-18.00 for 2007 and for 2008 the greatest percentage of suicide is on unknown time with 27.5%. The most frequent method of suicide was hanging for both years, with 64.9% for 2007, and 52.9% for 2008, fire arm with 14% for 2007 and 21.6% for 2008 and poisoning with 5.3% for 2007 and 11.8% for 2008. Suicides are most frequent at rural places but not significantly. CONCLUSION Suicides due to sex are significantly higher in males than females in all age groups. Average age of suicide victims is rising from 42 years for 2007 to 44 years for 2008. Suicides are more frequent at rural places and the greatest percentage of suicides due to months was on July for 2007 and June and October for 2008, on Wednesdays for 2007 and Tuesdays for 2008. PROPOSED MEASURES: Suicides are consequence of socioeconomic, psychological and political problems as unemployment and poverty. For challenging suicide phenomenon there is a need for multi-sectoral approach involving health and non health sector as politics, labor, education and media.
Tubulin immunoreactive neuronal intranuclear inclusions in the human brain

Intranuclear filamentous and crystalline inclusion bodies have been described in the nuclei of a variety of cells in both normal and pathological states. The functional significance of these structures remains to be elucidated. Moreover, although the proteinaceous nature of these inclusions has been inferred in some histochemical studies, the identity of their constituent proteins remains to be determined. In the present study, immunohistochemistry was used to investigate the presence of intranuclear inclusions in neurones of the human brain which are intensely immunoreactive for the neuronal cytoskeletal protein class III β tubulin. The ability to label these structures immunohistochemically was exploited to investigate the topographic pattern of distribution of these inclusions in the human brain. Intranuclear inclusions were rod‐shaped, polygonal, or irregular in shape. They were present in neurones and ependymal cells. Intranuclear inclusion‐bearing neurones were distributed in an anatomically heterogeneous pattern in the brain. Areas exhibiting relatively high densities of inclusions included the substantia inominata and anterior olfactory nucleus, dentate gyrus, substantia nigra, inferior olivary nucleus, and dentate nucleus of the cerebellum. In addition, intranuclear inclusions were prevalent in neurones in layers II, V, and VI of the cerebral cortex. They were particularly prevalent in the mesial basal temporal neocortex. The relationship of these structures to the intranuclear rods and sheets of the classical microscopists is uncertain. The demonstration that they are composed, at least in part, of tubulin, a major cytoskeletal protein, provides important clues regarding the mechanisms underlying their formation and provides a springboard for developing hypotheses regarding their functional significance. Furthermore, the ability to demonstrate these inclusions immunohistochemically provides an avenue for further studies directed at elucidating the potential involvement of these inclusions in various pathological settings.
Pulse wave velocity as an indicator of atherosclerosis in impaired fasting glucose: the Tanno and Sobetsu study.

OBJECTIVE Brachial-ankle pulse wave velocity (baPWV), as an indicator of atherosclerosis in impaired fasting glucose (IFG), was studied in 232 subjects randomly selected from inhabitants of two rural communities in Japan. RESEARCH DESIGN AND METHODS BMI, systolic blood pressure (SBP), fasting blood glucose (FBS), lipid parameters, ankle brachial pressure index (ABI), and baPWV were measured in each subject. ABI and baPWV were measured using the recently developed device, form ABI/PWV. The subjects were divided into three groups according FBS level: a normal group consisting of subjects with FBS <110 mg/dl, an IFG group consisting of subjects with FBS 110-125 mg/dl, and a diabetic group consisting of subjects with FBS > or =126 mg/dl and subjects taking hypoglycemic agents. The parameters in the three groups were compared. RESULTS-It was found that the baPWV value increased with increasing plasma glucose level. Significant differences were found between the baPWV values in the normal and IFG groups (1,518 vs. 1,673 cm/s, P = 0.01) and in the normal and diabetic groups (1,518 vs. 1,771 cm/s, P < 0.0001). The results of multiple regression analysis showed that FBS was closely related to baPWV as well as to age and SBP. CONCLUSIONS The relationship between IFG and atherosclerosis remains controversial. Further studies are needed to evaluate whether strict control of blood glucose level in patients with IFG will result in the prevention of atherosclerosis progression.
Guideline recommendations for treatment of schizophrenia: the impact of managed care.

BACKGROUND Medicaid-managed care has been shown to reduce the number and length of psychiatric hospitalizations, but little is known about the clinical and social consequences of such managed care programs. The purpose of this study was to compare the treatment of schizophrenia for disabled Medicaid beneficiaries who were and were not enrolled in managed care. METHODS This was a prospective observational study of patients who sought care for a psychiatric crisis from June 7, 1997, to May 13, 1999. Patients were followed up for 6 months. Inpatient and outpatient mental health facilities in Massachusetts were studied. The participants included 420 adult Medicaid beneficiaries, aged 24 to 64 years, who were treated for schizophrenia; 784 eligible beneficiaries were originally contacted and invited to participate (53.6% response). A private managed behavioral health care organization administered the Medicaid mental health benefit for about half the patients in the study. The other half were enrolled in the dually insured fee-for-service Medicare/Medicaid plan. The main outcome measures were adherence to the Schizophrenia Patient Outcomes Research Team treatment recommendations from inpatient and outpatient medical records, self-reported quality of interpersonal interactions between patient and clinician, self-reported care experiences and outcomes, and clinician-reported outcomes. RESULTS There were no differences between the managed care plan and the unmanaged fee-for-service plan in adherence to the schizophrenia treatment guidelines. However, much outpatient care in both programs was inconsistent with treatment guidelines. Inpatient treatment was far more likely to conform to guidelines than outpatient treatment. Patient ratings of their care were positive and not different between plans. Clinical outcome and health-related quality of life were not different between plans. CONCLUSIONS A major change in Massachusetts in the way mental health care is organized and financed had neither a negative nor a positive effect on care quality. However, adherence to nationally accepted guidelines for care was only modest, suggesting a need to improve the delivery of treatment to the most disabled highest-risk adults with schizophrenia.
Prevalence, risk factors, consequences and strategies for reducing medication errors in Australian hospitals: A literature review

Abstract The purpose of this paper is to examine medication errors in Australian hospitals from a nursing perspective. This paper provides a detailed review of past and current literature to examine prevalence rates and risk factors for medication errors. It also describes unintended injury or harm, also known as adverse events, associated with a medication error, and proposes strategies to counteract them. According to the literature, approximately two percent of patients in an acute hospital setting will experience a medication error. Administration of medications has remained a high risk task for registered nurses, and for this reason, the strategies to reduce error discussed in this paper will be predominantly nursing focussed. The occurrence of a medication error is a significant issue in the health care setting, and although the relative risk of an individual error occurring is low, the rate of error remains perceivably high in clinical practice today. With continual technological and pharmaceutical advances, the medication administration environment is becoming increasingly complex. Given the nature of medication therapy, it is near impossible to avoid all error, human and otherwise.
Aggressive Natural Killer Cell Leukemia: Report of a Chinese Series and Review of the Literature

Aggressive natural killer cell leukemia (ANKL) is a rare Epstein-Barr virus (EBV)-associated fulminating disease that is widely disseminated at diagnosis. Because of its typically extranodal presentation, differing degrees of NK cell involvement, and varying bone marrow pathology, ANKL can be confused with a reactive process. These features, coupled with a rapidly fatal course, have hampered systematic study of the pathogenesis of ANKL. Nine cases of ANKL were diagnosed and characterized by a single laboratory over a 2-year period. Constant features at presentation included disseminated disease, high fever, bone marrow involvement, and a high lactate dehydrogenase index. All cases were positive for EBV early region protein and negative for latent membrane protein 1, and all had a germline T-cell receptor gene configuration. Peripheral blood counts were variable, with severe thrombocytopenia being the most frequently encountered abnormality (7 of 9 cases). Hematophagocytosis, dyserythropoiesis, and stromal degeneration were the most frequent findings in the bone marrow. Neo-plastic cells in the bone marrow were consistently CD2+, CD56+, CD45+, CD34-, CD117-, CD4-, and surface CD3-. Most cases were HLA-DR+ (8/9) and CD8- (8/9). Complex clonal cytogenetic abnormalities were found in 8 of 9 cases. Because of its aggressive course, rapid and accurate diagnosis of ANKL is essential for a better understanding of the etiology, pathogenesis, and treatment of the disease.
Magnetic resonance enterocolonography in detecting erosion and redness in intestinal mucosa of patients with Crohn's disease

In Crohn's disease (CD), assessment of disease activity and extension is important for clinical management. Endoscopy is the most reliable tool for evaluating disease activity in these patients and it distinguishes between lesions based on ulcer, erosion, and redness. Magnetic resonance imaging (MRI) is less invasive than endoscopy; however, the sensitivity of MRI in detecting lesions is believed to be lower, and whether MRI can detect milder lesions has not been studied. The aim of this study was to compare the detection ability of magnetic resonance enterocolonography (MREC) with ileocolonic endoscopy in patients with CD.
Outcomes of maternal weight gain.

OBJECTIVES The RTI International-University of North Carolina at Chapel Hill Evidence-based Practice Center (RTI-UNC EPC) systematically reviewed evidence on outcomes of gestational weight gain and their confounders and effect modifiers, outcomes of weight gain within or outside the 1990 Institute of Medicine (IOM) guidelines, risks and benefits of weight gain recommendations, and anthropometric measures of weight gain. DATA SOURCES We searched MEDLINE Cochrane Collaboration resources, Cumulative Index to Nursing & Allied Health Literature, and Embase. REVIEW METHODS We included studies published in English from 1990 through October 2007. We excluded studies with low sample size (based on study design: case series <100 subjects and cohorts <40 subjects). RESULTS Overall, strong evidence supported an association between gestational weight gains and the following outcomes: preterm birth, total birthweight, low birthweight (<2,500 g), macrosomia, large-for-gestational-age (LGA) infants, and small-for-gestational-age (SGA) infants; moderate evidence supported an association for cesarean delivery and intermediate-term weight retention (3 months to 3 years postpartum). The studies reviewed provided strong evidence for the independent association of pregravid weight status and outcomes, moderate evidence for age and parity, and weak evidence for race. Regarding outcomes of weight gain within or outside 1990 IOM guidelines, moderate to strong evidence suggests an association between weight gain below IOM recommendations and preterm birth, low birthweight, SGA birthweights, and failure to initiate breastfeeding, and strong evidence for the association between weight gain above IOM recommendations and high birthweight, macrosomia, and LGA birthweights. Moderate evidence supports an association between weight gain above IOM guidelines and cesarean delivery and postpartum weight retention in the short, intermediate, and long term. Included research is inadequate for objective assessments of the range of harms and benefits of providing all women, irrespective of age, race or ethnicity, or pregravid body mass index (BMI), with the same recommendation for weight gain in pregnancy. CONCLUSIONS Gestational weight gain is associated with some infant and maternal outcomes. One weight gain recommendation for all women is not supported by the evidence identified in this review. To understand fully the impact of gestational weight gain on short- and long-term outcomes for women and their offspring will require that researchers use consistent definitions of weight gain during pregnancy, better address confounders in their analyses, improve study designs and statistical models, and conduct studies with longer followup.
Risk factors associated with deciduous tooth decay in Iraqi preschool children

Abstract Introduction: Tooth decay (TD) is common in children with significant consequences on systemic well-being, growth and quality of life, as well as increasing the risk of decay in the permanent teeth. Aim: The aim of the present study is to define risk factors associated with deciduous TD (DTD) in Iraqi preschool children. Materials and Methods: From the 1 st June to 31 st December 2012, a case-control study was carried out on 684 children under the age of 6 years who attended Al-Aulwyiah pediatric teaching hospital in Baghdad. Clinical examination and World Health Organization caries diagnostic criteria for decayed, missing and filled teeth (DMFT) were applied. Data including gender, residence, socio-economic status (SES), parental education level, parental smoking, tooth brushing frequency, type of feeding during infancy and the presence of any systemic disease in the child were sought. Results: The mean DMFT score in the case group was 2.03 ± 1.39, of which decayed teeth formed 1.93. Males had a higher mean DMFT (2.10 ± 1.08) than females (1.96 ± 1.70) but with no statistically significant difference. The study revealed that residence, SES, parental education level and tooth brushing frequency were dependent risk factors significantly associated with DTD. However, gender, parental smoking and pattern of feeding during infancy were not significantly associated with DTD. Only four children with systemic disorders (1.2%), namely asthma and congenital heart diseases, were noticed to have DTD. Conclusion: Pediatricians and dentists could provide dental preventive and screening measures. Confronting relevant risk factors associated with DTD and improving access to oral care services are suggested. In addition, promotion of oral health programs through school curricula is needed.