Miracle-dz/UniFAR-FTUs huggingface dataset:
An online paradigm for exploring the self-reference effect

People reliably encode information more effectively when it is related in some way to the self—a phenomenon known as the self-reference effect. This effect has been recognized in psychological research for almost 40 years, and its scope as a tool for investigating the self-concept is still expanding. The self-reference effect has been used within a broad range of psychological research, from cultural to neuroscientific, cognitive to clinical. Traditionally, the self-reference effect has been investigated in a laboratory context, which limits its applicability in non-laboratory samples. This paper introduces an online version of the self-referential encoding paradigm that yields reliable effects in an easy-to-administer procedure. Across four studies (total N = 658), this new online tool reliably replicated the traditional self-reference effect: in all studies self-referentially encoded words were recalled significantly more than semantically encoded words (d = 0.63). Moreover, the effect sizes obtained with this online tool are similar to those obtained in laboratory samples, and are robust to experimental variations in encoding time (Studies 1 and 2) and recall procedure (Studies 3 and 4), and persist independent of primacy and recency effects (all studies).
Comparison of Proteolytic Activities Produced by Entomopathogenic Photorhabdus Bacteria: Strain- and Phase-Dependent Heterogeneity in Composition and Activity of Four Enzymes

ABSTRACT Twenty strains (including eight phase variant pairs) of nematode-symbiotic and insect-pathogenic Photorhabdus bacteria were examined for the production of proteolytic enzymes by using a combination of several methods, including gelatin liquefaction, zymography coupled to native and sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and activity measurement with two chromogen substrate types. Four protease activities (∼74, ∼55, ∼54, and ∼37 kDa) could be separated. The N-terminal sequences of three of the proteases were determined, and a comparison with sequences in databases allowed identification of these proteases as HEXXH metallopeptidases. Thus, the 74-kDa protease (described formerly as Php-B [J. Marokházi, G. Kóczán, F. Hudecz, L. Gráf, A. Fodor, and I. Venekei, Biochem. J. 379:633-640, 2004) is an ortholog of OpdA, a member the thimet oligopeptidase family, and the 55-kDa protease is an ortholog of PrtA, a HEXXH+H peptidase in clan MB (metzincins), while the 37-kDa protease (Php-C) belongs to the HEXXH+E peptidases in clan MA. The 54-kDa protease (Php-D) is a nonmetalloenzyme. PrtA and Php-C were zymographically detected, and they occurred in several smaller forms as well. OpdA could not be detected by zymography. PrtA, Php-C, and Php-D were secreted proteases; OpdA, in contrast, was an intracellular enzyme. OpdA activity was found in every strain tested, while Php-D was detected only in the Brecon/1 strain. There was significant strain variation in the secretion of PrtA and Php-C activities, but reduced activity or a lack of activity was not specific to secondary-phase variants. The presence of PrtA, OpdA, and Php-C activities could be detected in the hemolymph of Galleria melonella larvae 20 to 40 h postinfection. These proteases appear not to be directly involved in the pathogenicity of Photorhabdus, since strains or phase variants lacking any of these proteases do not show reduced virulence when they are injected into G. melonella larvae.
The Effects of Glucagon-like Peptide-2 on the Tight Junction and Barrier Function in IPEC-J2 Cells through Phosphatidylinositol 3-kinase–Protein Kinase B–Mammalian Target of Rapamycin Signaling Pathway

Glucagon-like peptide-2 (GLP-2) is important for intestinal barrier function and regulation of tight junction (TJ) proteins, but the intracellular mechanisms of action remain undefined. The purpose of this research was to determine the protective effect of GLP-2 mediated TJ and transepithelial electrical resistance (TER) in lipopolysaccharide (LPS) stressed IPEC-J2 cells and to test the hypothesis that GLP-2 regulate TJ and TER through the phosphatidylinositol 3-kinase (PI3K)-protein kinase B (Akt)-mammalian target of rapamycin (mTOR) signaling pathway in IPEC-J2 cells. Wortmannin and LY294002 are specific inhibitors of PI3K. The results showed that 100 μg/mL LPS stress decreased TER and TJ proteins occludin, claudin-1 and zonula occludens protein 1 (ZO-1) mRNA, proteins expressions (p<0.01) respectively. GLP-2 (100 nmol/L) promote TER and TJ proteins occludin, claudin-1, and zo-1 mRNA, proteins expressions in LPS stressed and normal IPEC-J2 cells (p<0.01) respectively. In normal cells, both wortmannin and LY294002, PI3K inhibitors, prevented the mRNA and protein expressions of Akt and mTOR increase induced by GLP-2 (p<0.01) following with the significant decreasing of occludin, claudin-1, ZO-1 mRNA and proteins expressions and TER (p<0.01). In conclusion, these results indicated that GLP-2 can promote TJ’s expression and TER in LPS stressed and normal IPEC-J2 cells and GLP-2 could regulate TJ and TER through the PI3K/Akt/mTOR pathway.
Leucocyte Antibodies in Sera of Pregnant Women

1 The leucocyte agglutinins arising during pregnancy are isoantibodies directed against an antigen present on the leucocytes of the husband and some of the children. 2 With the aid of such sera it is possible to recognize leucocyte groups. 3 These antibodies can cause transfusion reactions. 4 The antigens against which these antibodies are directed are found not only on the leucocytes but also on the thrombocytes, and in placental tissue. They are not found on the erythrocytes. 5 The possible significance of these antibodies in connection with spontaneous abortion is mentioned.
Automated input data management: evaluation of a concept for reduced time consumption in discrete event simulation

Input data management is a crucial and time-consuming part of a simulation project. Consequently, improvement of this process has substantial potential to increase the rapidity of simulation projects, thus enabling more detailed analyses in design and development of production systems. This paper presents the development of a concept and an associated software demonstrator called the Generic Data Management Tool (GDM-Tool), which automates several critical and time-consuming data input activities. More specifically, raw data are extracted from multiple sources, with different data structures, and transformed to simulation input through data cleaning, calculations and distribution fitting, all done in one automated process. Finally, the simulation input is presented in the Core Manufacturing Simulation Data format, for further use in simulation applications. As a first step towards validation, the GDM-Tool was evaluated during a case study in the automotive industry. The results show that the time needed for input data management was reduced by 78%, as relative to a traditional manual approach.
Clinical, pathological, and neurochemical changes in dementia: A subgroup with preserved mental status and numerous neocortical plaques

Postmortem examination was performed on 137 residents (average age 85.5 years) of a skilled nursing facility whose mental status, memory, and functional status had been evaluated during life. Seventy‐eight percent were demented using conservative criteria; 55% had characteristic Alzheimer's disease. Choline acetyltransferase and somatostatin were significantly reduced in the brains of patients with Alzheimer's disease as compared with age‐matched nursing home control subjects, although the degree of the reduction was less severe than found in subjects less than 80 years of age. Ten subjects whose functional and cognitive performance was in the upper quintile of the nursing home residents, as good as or better than the performance of the upper quintile of residents without brain pathology (control subjects), showed the pathological features of mild Alzheimer's disease, with many neocortical plques. Plaque counts were 80% of those of demented patients with Alzheimer's disease. Choline acetyltransferase and somatostatin levels were intermediate between controls and demented patients with Alzheimer's disease. The unexpected findings in these subjects were higher brain weights and greater number of neurons (> 90μm2 in a cross‐sectional area in cerebral cortex) as compared to age‐matched nursing home control subjects. These people may have had incipient Alzheimer's disease but escaped loss of large neurons, or alternatively, started with larger brains and more large neurons and thus might be said to have had a greater reserve.
Cryptococcus neoformans Shows a Remarkable Genotypic Diversity in Brazil

ABSTRACT The genotypic diversity of Brazilian Cryptococcus neoformans strains was analyzed. The majority of the samples were αA (65%), followed by αB (17.5%), αD (9%), αAaD hybrids (5%), and αC (3.5%). A considerable genotypic diversity occurred within C. neoformans var. grubii, and a new amplified fragment length polymorphism genotype, 1B, was recognized.
Mycophenolate mofetil as a treatment for refractory idiopathic thrombocytopenic purpura

AbstractAim:To determine whether mycophenolate mofetil (MMF) has beneficial effects on refractory idiopathic thrombocytopenic purpura (ITP) and the corresponding cellular mechanism.Methods:Twenty refractory ITP patients resistant to corticosteroid and/or splenectomy and chemical therapy were given MMF 1.5-2.0 g/d orally for a 2 to 4-month period. Serum immunoglobulin was detected by rate nephelometry. Platelet-associated antibodies (PAIgG) were assayed by enzyme-linked immunosorbant assay. The immunophenotypic analysis was performed on a flow cytometer and cell apoptosis was detected with transferase mediated dUTP biotin nick end labeling (TUNEL) method.Results:Sixteen of the 20 (80%) patients had responses to MMF treatment; 9 (45%) achieved a complete response, 4 (20%) achieved a partial response, and 3 (15%) achieved a minor response. The therapeutic effects were found to be better in male patients than female patients. The number of CD3+ peripheral blood cells (PBCs) and CD4+ PBCs increased and the number of CD8+ PBCs decreased. The plasma level of IgG, IgM, IgA and platelet associated IgG (PAIgG) decreased in 86% of the patients. TUNEL assay showed that mycophenolate acid (MPA) 0.1 mmol/L induced apoptosis of peripheral blood mononuclear cells isolated from refractory ITP patients. The apoptosis rate was increased in male patients after treatment with MPA, but was unchanged in female patients.Conclusion:Therapy for a period of 8 to 16 weeks with mediandose of MMF was valuable for the treatment of refractory ITP.
Dividing the FEV1 into its component parts.

to the editor: Sorkness et al. ([1][1]) show that the forced expiratory volume in 1 s (FEV1) expressed as percent predicted can be broken down into its two components, forced vital capacity (FVC) and FEV1/FVC, also expressed as percent predicted. They claim that “this is a novel approach [for
The afferent and efferent connections of the ventromedial thalamic nucleus in the rat

The afferent and efferent connections of the ventromedial (VM) nucleus of the thalamus in the rat were studied by experiments using the methods of retrograde cell marking by horseradish peroxidase (HRP) and anterograde fiber tracing by autoradiography. Tritiated amino acids deposited microelectrophoretically into VM label a cortical projection that is distributed to a sharply defined superficial portion of layer I of almost the entire extent of the ipsilateral neocortex. The labeling is most dense at frontal cortical levels, where fibers radiate through the deeper layers to terminate in the outer one‐quarter of layer I throughout all neocortex rostral to the genu of the corpus callosum. A lesser number of labeled fibers extends caudally in a supracallosal location to innervate parieto‐occipital cortical areas. Labeled collaterals ascend through the cortical layers to reach layer I, where grains in the superficial portion are found in a gradually decreasing rostrocaudal gradient of density that reaches the caudal pole of the hemisphere. Coronal sections at most levels contain a band of labeling in layer I that extends uninterrupted from the callosal sulcus at the midline to the banks of the rhinal sulcus laterally. Caudal retrosplenial and ventral temporal areas appear to be the only sectors of neocortex spared by the ubiquitous projection. Evidence for additional terminal distribution in deeper layers is found only in the dorsal and lateral sectors of the cortex rostral to the genu where sparsely labeled bands appear in layers III and V. The nearly exclusive distribution of VM's cortical afferents to layer I is compared and contrasted with multilaminar distributions of other “unspecific” cortical afferent fibers.
Navajo spatial representation and Navajo geometry

Rik Pinxten presenta un informe de su proyecto en curso. Se trata de la representacion de los Navajo ; el autor muestra algunas notas sobre las perspectivas generales de la ensenanza de la geometria y un ejemplo utilizado para implementar el pensamiento geometrico a partir del sistema de representacion espacial nativo.
Effects of chronic ETA-receptor blockade in angiotensin II-induced hypertension.

Angiotensin II, a constrictor and mitogen of vascular smooth muscle cells, affects the release of endothelium-derived factors such as nitric oxide or endothelin-1. This study investigated the influence of endothelin-1, using the selective endothelin A receptor antagonist LU135252, on blood pressure and endothelial function in angiotensin II-induced hypertension in the rat. Two weeks of angiotensin II administration (200 ng/kg per minute) increased systolic blood pressure (+35 +/- 5 mm Hg; tail-cuff method) compared with placebo (P < .05). LU135252 alone did not affect systolic pressure but lowered the angiotensin II-induced pressure increase (P < .05). In isolated aortic rings, endothelium-dependent relaxations to acetylcholine were reduced in the angiotensin II group (P < .05 versus placebo) and improved by concomitant chronic LU135252 treatment (P < .05 versus angiotensin II). Blood pressure elevation strongly correlated with impaired endothelium-dependent relaxations to acetylcholine (r = -.967). LU135252 did not affect endothelium-independent relaxations to sodium nitroprusside, which were diminished after angiotensin II treatment (P < .05). In quiescent rings, chronic angiotensin II administration enhanced endothelium-dependent contractions to acetylcholine, which were reduced by LU135252 (P < .05). Impaired contractions to endothelin-1 and norepinephrine in the angiotensin II group were normalized after treatment with LU135252 (P < .05). Thus, chronic therapy with LU135252 partially prevents angiotensin II-induced hypertension and the alternations of the endothelial function observed in this experimental model.
Effect of a Patient Navigator Program on the Volume and Quality of Colonoscopy

Background and Goals To increase colorectal cancer screening among urban minorities, New York Presbyterian Hospital/Columbia University, with support from the New York City Department of Health and the Citywide Colon Cancer Control Coalition (C5), instituted a patient navigation and direct endoscopic referral system. We assessed the effect of this program on the volume of colonoscopy in this institution, which caters to a socioeconomically diverse patient population. Study We compared colonoscopy volume during the first year of the navigator program with the volume during the year before this program. We stratified on Medicaid status to assess the secular trend of screening rates. To assess quality during this period, we measured cecal intubation rates, preparation quality, and adenoma detection rates. Results Of the 749 patients assessed by the patient navigators, 678 (91%) underwent colonoscopy. Colonoscopy volume among the Medicaid outpatients increased by 56% (957 to 1489). Adenoma detection was 27% and the cecal intubation rate was 97%. Comparing navigated patients with the nonnavigated Medicaid outpatients, preparation quality was superior (34% vs. 40% suboptimal, P=0.0282), although preparation quality remained inferior to that of private patients (20% suboptimal, P<0.0001). Conclusions Volume of the colonoscopy increased, coinciding with the onset of the patient navigation program. This increase was nearly entirely owing to a rise in the colonoscopies among Medicaid outpatients, the principal focus of the navigator program. This increase in quantity was accomplished while maintaining an overall high level of quality as measured by cecal intubation rates and adenoma detection, although preparation quality requires further efforts at improvement.
Serum osteoprotegerin as a determinant of bone metabolism in a longitudinal study of human pregnancy and lactation.

Osteoprotegerin (OPG) is a soluble decoy receptor that inhibits bone resorption by binding to receptor activator of nuclear factor kappa B ligand. Murine studies suggest that OPG is elevated in pregnancy, but its role in human pregnancy is unknown. We evaluated the relationship among OPG, bone turnover, and bone density in a longitudinal study of planned human pregnancy and lactation (n = 17; age, 20-36 yr). Samples were collected before conception; at 16, 26, and 36 wk gestation; and at 2 and 12 wk postpartum. Indexes of bone resorption included serum beta C-terminal and urinary N-terminal (uNTX) telopeptides of type I collagen. OPG increased by 110 +/- 16% (mean +/- SEM) at 36 wk (P < 0.001), followed by a rapid postpartum decline in both lactating and nonlactating women. Bone resorption was elevated at 36 wk (serum beta C-terminal telopeptides by 76 +/- 17%; urinary N-terminal telopeptides by 219 +/- 41%; P < 0.001). The tissue source of OPG in pregnancy is unknown. Human breast milk contains large amounts of OPG (162 +/- 58 ng/ml in milk vs. 0.42 +/- 0.03 ng/ml in nonpregnant serum). However, the rapid postpartum decline in serum OPG and the low serum OPG in neonates suggest a placental source. There was no correlation between change in OPG and bone turnover or bone mineral density (P > 0.05), and the physiological importance of elevated OPG in human pregnancy remains uncertain.
Classification of diffuse large B-cell lymphoma by immunohistochemistry demonstrates that elderly patients are more common in the non-GC subgroup and younger patients in the GC subgroup

In accordance with a recent study by Mareschal et al. , in which they classified diffuse large B-cell lymphoma (DLBCL) by using expression profiling techniques, we show that elderly patients (≥ 80 years) are more common in the “non-germinal center subgroup” (non-GC) compared to younger
Resources for Enhancing Alzheimer's Caregiver Health (REACH): overview, site-specific outcomes, and future directions.

Established in 1995, Resources for Enhancing Alzheimer’s Caregiver Health (REACH) is a unique, multisite research program sponsored by the National Institute on Aging and the National Institute on Nursing Research. The primary purpose of REACH is to carry out social and behavioral research on interventions designed to enhance family caregiving for Alzheimer’s disease (AD) and related disorders. Specifically, REACH has two goals: to test the effectiveness of multiple different interventions and to evaluate the pooled effect of REACH interventions overall. REACH developed from a National Institutes of Health initiative that acknowledged the well-documented burdens associated with family caregiving as well as the existence of promising family caregiver interventions reported in the literature.
Transmastoid extracranial repair of CSF leaks following acoustic neuroma resection

Abstract Acoustic neuromas may be resected either by a suboccipital craniectomy or translabyrinthine approach; the latter gives good access without unduly traumatising the brainstem, but can lead to a higher incidence of cerebrospinal fluid (CSF) leaks. The surgical management of these leaks can be difficult; we describe a transmastoid extracranial technique using pedicled sternomastoid muscle that has produced complete resolution of the leak in all cases managed in this way.
Calculated or caring? Neanderthal healthcare in social context

ABSTRACT Explanations for patterns of healed trauma in Neanderthals have been a matter of debate for several decades. Despite widespread evidence for recovery from injuries or survival despite impairments, apparent evidence for healthcare is given limited attention. Moreover, interpretations of Neanderthals’ approach to injury and suffering sometimes assume a calculated or indifferent attitude to others. Here the authors review evidence for Neanderthal healthcare, drawing on a bioarchaeology of care approach and relating healthcare to other realms of Neanderthal social life. The authors argue that Neanderthal medical treatment and healthcare was widespread and part of a social context of strong pro-social bonds which was not distinctively different from healthcare seen in later contexts. They suggest that the time has come to accept Neanderthal healthcare as a compassionate and knowledgeable response to injury and illness, and to turn to other questions, such as cultural variation or the wider significance of healthcare in an evolutionary context.
Aided/Automatic Target Detection Using Reflective Hyperspectral Imagery for Airborne Applications

Abstract : This paper presents an algorithm to support airborne, real-time automatic target detection using combined EO/IR spatial and spectral discriminants for remote sensing surveillance and reconnaissance applications. The algorithm presented in this paper is sufficiently robust and optimized to accommodate high throughput, real-time, sub-pixel, hyperspectral target detection, and can also be used to support man-in-the loop or automatic target detection. The essence of this algorithm is the ability to select the adaptive endmember spectral signatures in real-time, regardless of target, background, and system related effects such as atmospheric conditions, calibration or sensor artifacts. Based on the selected endmembers, the spectral angle of the endmembers is used as the discriminant for target detection or terrain identification. The detection performance and false alarm rate (FAR) including the performances of different combinations of individual bands will be quantified. Statistical analysis including class distributions, various moments of hyperspectral data, and the endmember spectral signatures is examined. The Forest Radiance I database is collected with the HYDICE hyperspectral sensor (reflective spectral band of 0.4um to 2.5um) at Aberdeen U. S. Army Proving Ground in Maryland. The data set covers an area of about 10 sq km.
Factors Influencing Administrative Staffs toward the Adoption of Cloud Computing

Adoption of new Information and Communication Technologies (ICT) has been one of the most challenging issues in developing part of the world. Uptake of new ICT innovations involves fulfilling many requirements ranging from technical to human resources. This study investigated factors influencing administrative staffs toward the adoption of cloud computing. Unified Theory of Acceptance and Use of Technology (UTAUT) model serves as an assessment framework to understand administrative staffs’ behavioral intention towards cloud computing. The results of T-test showed that there is no significant influence of gender on effort expectancy, performance expectancy and social influence of administrative staffs towards the adoption of cloud computing. Similarly, results of ANOVA revealed there is no significant influence of age on effort expectancy, performance expectancy and social influence of administrative staffs towards the adoption of cloud computing. On the other hand, the result of Linear regression showed that there is a significant relationship between effort expectancy, performance expectancy, social influence and facilitating conditions on administrative staff’s behavioral intention towards the adoption of cloud computing. Knowledge gained from the study is advantageous to both the tertiary administrative staffs and the Nigerian ICT policy makers.