Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of Background Scene Complexity and Field Dependence on the Legibility of Head-Up Displays for Automotive Applications

This study examined the legibility of information presented on head-up displays (HUDs) for automotive application as a function of background scene complexity, the position of the HUD within field of view relative to the background scene, and the perceptual capacity of the perceiver. Groups of field-dependent and fieldindependent subjects viewed video footage from the perspective of following a lead caron an open road with low, moderate, and high scene complexity. Subjects were required to track the lead vehicle and identify HUD-presented targets of a specified orientation and specified changes in a HUD-presented speedometer. The results indicate that (a) HUD legibility deteriorated with increased visual complexity of the background scene; (b) positioning the HUD on the roadway reduced the effect of background scene complexity on HUD legibility; and (c) field-dependent subjects made fewer correct and more false positive target identifications than did field-independent subjects.
Increase of HIV-1 Pro-Viral Dna per Million Peripheral Blood Mononuclear Cells in Patients with Advanced HIV Disease (Cd4<200 Cells/Mm3) Receiving Interleukin 2 Combined with Haart Versus Haart Alone (Anrs-082 Trial)

Objective To assess the effect of interleukin (IL)-2 combined with highly active antiretroviral therapy (HAART) on HIV-1 pro-viral DNA quantification in HIV-1-infected patients with CD4<200/mm3. Patients and methods Seventy patients with CD4<200 cells/mm3 and CV<1000 copies/ml were enrolled in a 6-month randomized controlled study to evaluate the subcutaneous injection of IL-2 in addition to HAART versus HAART alone. Then, in a non-comparative phase from week 28 to week 80, IL-2 was proposed to patients from both groups. The HIV-1 pro-viral DNA was quantified at baseline, week 24 and week 50 by a real-time polymerase chain reaction (PCR) assay in peripheral blood mononuclear cells (PBMC). Analysis of resistance mutations was performed at baseline and after 6-months of IL-2. Results HIV-1 DNA level in PBMC increased significantly in patients treated with 6 months of HAART combined to IL-2 (+0.24 log10, P=0.009) compared to a slight decrease in patients treated with HAART alone (–0.05 log10). Moreover, a DNA increase was observed in control group patients when receiving 6 months of IL-2 (+0.34 log10). No increase of HIV-1 DNA was seen when this measure was expressed per million CD4 cells; it was probably hidden by the intense increase of CD4 lymphocytes after 6 months of IL-2 administration. No evolution of resistance mutations in pro-viral DNA was observed during 6 months of IL-2, despite the increase of pro-viral DNA and the occurrence of transient increase of viraemia. Conclusion Administration of IL-2 combined with HAART in HIV-1 infected-patients with advanced disease led to an increase of HIV-1 pro-viral DNA per million PBMC without virological failure or emergence of resistance.
Clostridium perfringens &agr;-Toxin and NetB Toxin Antibodies and Their Possible Role in Protection Against Necrotic Enteritis and Gangrenous Dermatitis in Broiler Chickens

SUMMARY. Necrotic enteritis (NE) and gangrenous dermatitis (GD) are important infectious diseases of poultry. Although NE and GD share a common pathogen, Clostridium perfringens, they differ in other important aspects such as clinical signs, pathologic symptoms, and age of onset. The primary virulence factors of C. perfringens are its four major toxins (&agr;, &bgr;, &egr;, &igr;) and the newly described NE B-like (NetB) toxin. While neutralizing antibodies against some C. perfringens toxins are associated with protection against infection in mammals, the serologic responses of NE- and GD-afflicted birds to these toxins have not been evaluated. Therefore, we measured serum antibody levels to C. perfringens &agr;-toxin and NetB toxin in commercial birds from field outbreaks of NE and GD using recombinant toxin-based enzyme-linked immunosorbent assay (ELISA). Initially, we used this ELISA system to detect antibody titers against C. perfringens &agr;-toxin and NetB toxin that were increased in birds experimentally co-infected with Eimeria maxima and C. perfringens compared with uninfected controls. Next, we applied this ELISA to field serum samples from flock-mated birds with or without clinical signs of NE or GD. The results showed that the levels of antibodies against both toxins were significantly higher in apparently healthy chickens compared to birds with clinical signs of NE or GD, suggesting that these antitoxin antibodies may play a role in protection against NE and GD.
Skeletal muscle fatigue and physical endurance of young and old mice

In order to evaluate the role played by muscular and extramuscular factors in the development of fatigue in old age, the time course of fatigue in isolated skeletal muscles and spontaneous motor activity and endurance of whole animals were monitored using young (3–6 months) and old (34–36 months) CF57BL/6J mice. The isolated extensor digitorum longus (EDL) and soleus muscles from old mice had smaller (P < 0.05) mass and developed lower (P < 0.02) maximal tetanic tension at 100‐Hz stimulation than the muscles of young mice. During stimulation at 30 Hz every 2.5 s, a 50% decline in original tetanic tension occurred by 109 s in young EDL and 129 s in old EDL, but by 482 s in young soleus and 1134 s (projected) in old soleus, indicating more (P < 0.05) resistance to fatigue in old than young soleus. However, the old mice showed significantly fewer (P < 0.002) spontaneous ambulatory movements than the young mice. On a treadmill with a belt speed of 10 m/min at an inclination of 0°, the old mice could only run for 22 min compared to 39 min ran by young mice (P < 0.02). They took more rest periods (P < 0.02) than the young mice. In a quantitative swimming monitor, the old mice swam for a shorter (P < 0.05) time than young mice (20.4 min compared to 28.6 min). Integrated swimming activity at 20 min was smaller (P < 0.05) in old mice than in young mice (413 g/s compared to 628 g/s). Hence increased fatigue in old age is not caused by impairment of processes within the muscles, but by impairment of central or extramuscular processes. © 1998 John Wiley & Sons, Inc. Muscle Nerve 21: 1729–1739, 1998
Peripheral resolution using stationary and flickering gratings: the effects of age.

PURPOSE Currently, little or no psychophysical data exist on the decline in retinal ganglion cell density, with age or on the nature of any selective age-related loss of one cell type over another. The authors wished to determine the nature of any decline in ganglion cell density with age using measurements of peripheral grating resolution, which is directly related to ganglion cell sampling density. METHODS We measured grating resolution at 4 different retinal locations in a group of 97 normal subjects ranging in age from eight to eighty-one years. Stimuli were either stationary or employed counterphase flicker at 30 Hz in order to selectively stimulate a greater proportion of either P or M ganglion cells. RESULTS Mean resolution was significantly higher for stationary gratings than flickering gratings. Loss of peripheral resolution was approximately 5%/decade for stationary gratings and 6%/decade for flickering gratings. The ratio of resolution for flickering/non-flickering stimuli showed a small but insignificant decline with age. CONCLUSIONS There is a general decline in peripheral resolution with age, indicating a corresponding loss of retinal ganglion-cell density. This age-related loss does not appear to be very selective in terms of cells that are sensitive to either stationary or flickering gratings. These results increase the diagnostic power of clinical tests that employ measures of peripheral resolution in subjects of different ages to detect diseases which cause loss of ganglion cells.
B Cells and TCR Avidity Determine Distinct Functions of CD4+ T Cells in Retroviral Infection

The T cell-dependent B cell response relies on cognate interaction between B cells and CD4+ Th cells. However, the consequences of this interaction for CD4+ T cells are not entirely known. B cells generally promote CD4+ T cell responses to pathogens, albeit to a variable degree. In contrast, CD4+ T cell responses to self- or tumor Ags are often suppressed by B cells. In this study, we demonstrated that interaction with B cells dramatically inhibited the function of virus-specific CD4+ T cells in retroviral infection. We have used Friend virus infection of mice as a model for retroviral infection, in which the behavior of virus-specific CD4+ T cells was monitored according to their TCR avidity. We report that avidity for Ag and interaction with B cells determine distinct aspects of the primary CD4+ T cell response to Friend virus infection. Virus-specific CD4+ T cells followed exclusive Th1 and T follicular helper (Tfh) differentiation. High avidity for Ag facilitated expansion during priming and enhanced the capacity for IFN-γ and IL-21 production. In contrast, Tfh differentiation was not affected by avidity for Ag. By reducing or preventing B cell interaction, we found that B cells promoted Tfh differentiation, induced programmed death 1 expression, and inhibited IFN-γ production by virus-specific CD4+ T cells. Ultimately, B cells protected hosts from CD4+ T cell-mediated immune pathology, at the detriment of CD4+ T cell-mediated protective immunity. Our results suggest that B cell presentation of vaccine Ags could be manipulated to direct the appropriate CD4+ T cell response.
Prospective, naturalistic study of open-label OROS methylphenidate treatment in Chinese school-aged children with attention-deficit/hyperactivity disorder.

BACKGROUND Attention deficit hyperactivity disorder (ADHD) is one of the most common mental disorders during childhood, characterized by the core symptoms of hyperactivity, impulsivity and inattention and puts great burden on children themselves, their families and the society. Osmotic release oral system methylphenidate (OROS-MPH) is a once-daily controlled-release formulation developed to overcome some of the limitations associated with immediate-release methylphenidate (IR-MPH). It has been marketed in China since 2005 but still lacks data from large-sample clinical trials on efficacy and safety profiles. The aim of this study was to evaluate the effectiveness and safety of OROS-MPH in children aged 6 to 16 years with ADHD under naturalistic clinical setting. METHODS This 6-week, multi-center, prospective, open-label study enrolled 1447 ADHD children to once-daily OROS-MPH (18 mg, 36 mg or 54 mg) treatment. The effectiveness measures were parent-rated Inattention and Overactivity With Aggression (IOWA) Conners I/O and O/D subscales, physician-rated CGI-I and parent-rated global efficacy assessment scale. Blood pressure, pulse rate measurement, adverse events (AEs) and concomitant medications and treatment review were conducted by the investigator and were served as safety measures. RESULTS A total of 1447 children with ADHD (mean age (9.52 ± 2.36) years) were enrolled in this trial. Totally 96.8% children received an OROS-MPH modal dose of 18 mg, 3.1% with 36 mg and 0.1% with 54 mg at the endpoint of study. The parent IOWA Conners I/O score at the end of week 2 showed statistically significant (P < 0.001) improvement with OROS-MPH (mean: 6.95 ± 2.71) versus the score at baseline (10.45 ± 2.72). The change in the parent IOWA Conners O/D subscale, CGI-I and parent-rated global efficacy assessment scale also supported the superior efficacy for OROS-MPH treatment. Fewer than half of 1447 patients (511(35.3%)) reported AEs, and the majority of the events reported were mild (68.2%). No serious adverse events were reported during the study. CONCLUSION This open-label, naturalistic study provides further evidence of effectiveness and safety of OROS-MPH in school-aged children under routine practice.
Transmission, group delay, and dispersion in single-ring optical resonators and add/drop filters-a tutorial overview

This tutorial describes the transmission, group delay time and quadratic dispersion properties of the four basic building blocs of optical filters built using ring resonators. These building blocs are single-ring resonators in either two-port (all-pass) or four-port (add/drop filter) configuration. The effect of waveguide and coupler loss is included throughout. Explicit expressions to compute the complex amplitude of the circulating wave in the ring, the Q factor, the finesse and the insertion loss are also given. Attention is drawn to the similarities between the ring resonator the Fabry-Pe/spl acute/rot resonator and the Gires-Tournois interferometer. Material properties and fabrication technology are not reviewed.
Comparative Study of OKR and KPI

OKR (objectives and key results) is popular in field of performance management recently, and is adopted by many leading companies. In this study, we compared OKR with KPI (key performance indicators), one famous traditional performance appraisal tool. The characteristics of OKR and its operation mechanism were analyzed; the advantages and disadvantages of KPI and OKR were concluded. In addition, the similarity and difference between OKR and KPI were explored.
Understanding surgical decision making in early hepatocellular carcinoma.

PURPOSE The choice between liver transplantation (LT), liver resection (LR), and radiofrequency ablation (RFA) as initial therapy for early hepatocellular carcinoma (HCC) is controversial, yet little is known about how surgeons choose therapy for individual patients. We sought to quantify the impact of both clinical factors and surgeon specialty on surgical decision making in early HCC by using conjoint analysis. METHODS Surgeons with an interest in liver surgery were invited to complete a Web-based survey including 10 case scenarios. Choice of therapy was then analyzed by using regression models that included both clinical factors and surgeon specialty (non-LT v LT). RESULTS When assessing early HCC occurrences, non-LT surgeons (50% LR; 41% LT; 9% RFA) made significantly different recommendations compared with LT surgeons (63% LT; 31% LR; 6% RFA; P < .001). Clinical factors, including tumor number and size, type of resection required, and platelet count, had significant effects on the choice between LR, LT, and RFA. After adjusting for clinical factors, non-LT surgeons remained more likely than LT surgeons to choose LR compared with LT (relative risk ratio [RRR], 2.67). When the weight of each clinical factor was allowed to vary by surgeon specialty, the residual independent effect of surgeon specialty on the decision between LR and LT was negligible (RRR, 0.93). CONCLUSION The impact of surgeon specialty on choice of therapy for early HCC is stronger than that of some clinical factors. However, the influence of surgeon specialty does not merely reflect an across-the-board preference for one therapy over another. Rather, certain clinical factors are weighed differently by surgeons in different specialties.
Meta‐analysis of B type natriuretic peptide and N‐terminal pro B natriuretic peptide in the diagnosis of clinical heart failure and population screening for left ventricular systolic dysfunction

Background: We set out to review the validity of tests for B type natriuretic peptide (BNP) and N‐terminal pro BNP (NTproBNP) in the diagnosis of clinical heart failure (HF) in primary care and hospital settings and to examine the effect of age. We also examined the accuracy of the test in population screening for left ventricular systolic dysfunction.
Dietary Habits, Internal Migration and Social Class in a Sample of a Northern Italian Population

The study of migrants has generated interesting hypotheses on the etiology of different types of cancer. In particular, it has been suggested that both colon and breast cancer could be related to living conditions, including diet, in the country of immigration. Considerable internal migration occurred in Italy in the sixties. We studied a random sample of 1,400 subjects living in the city of Torino and the province of Varese. They were interviewed with a detailed questionnaire about their dietary habits, and the consumption of several nutrients was considered according to the area of birth and social class. The hypothesis we tested was whether, after controlling for social class, there were different dietary habits among the migrants and the native population, and whether such differences could help in the formulation of etiologic hypotheses on cancer. We found that the intake of saturated fatty acids and cholesterol was lower among the migrants from the south, whereas they consumed higher levels of vegetables than people born in the north. The different intake of saturated fatty acids and cholesterol seemed to be attributable mainly to the consumption of butter, for which the south/north ratio was as low as 0.47 in men and 0.56 in women. Important gradients by social class were also suggested for several nutrients.
Late effects of allogeneic bone marrow transplantation for children with acute myeloblastic leukemia in first complete remission: the impact of conditioning regimen without total-body irradiation--a report from the Société Française de Greffe de Moelle.

PURPOSE To evaluate growth, thyroid function, puberty, cardiac function, and the incidence of cataracts in children who received allogeneic bone marrow transplantation (BMT) for acute myeloblastic leukemia (AML) in first complete remission (CR) after a preparation with or without total-body irradiation (TBI). PATIENTS AND METHODS Among 45 children studied, 26 received busulfan-cyclophosphamide (Bu-Cy) in preparation for transplantation and 19 received TBI. TBI was fractionated in nine cases and delivered as a single dose in 10. Four children in the Bu-Cy group and none in the TBI group had received prior cranial radiation. The mean follow-up duration after BMT was 5.9 years for the whole group. RESULTS The mean cumulative changes in height SD score (SDS) were -0.86 at 3 years and -1.56 at 5 years in the TBI group, whereas these changes were only -0.05 and -0.17 in the Bu-Cy group (P < .01 at 3 and 5 years). The 6-year probability of hypothyroidism was 9% +/- 8% in the Bu-Cy group and 43% +/- 15% after TBI (P < .02). Pubertal development after Bu-Cy was assessable in two girls and five boys: both girls had primary ovarian failure, whereas Leydig cell function appeared to be preserved in the five boys. One child who had received anthracycline when he was less than 1 year old developed cardiac dysfunction 4 years after Bu-Cy. The 6-year probability of cataracts was 70% +/- 13% in the TBI group and 0% after Bu-Cy. CONCLUSION The use of Bu-Cy represents an alternative transplant cytoreductive regimen for children with AML in first CR, which can reduce the risk of posttransplant growth impairment, thyroid dysfunction, Leydig cell damage, and the incidence of cataracts.
Scene-Adapted Plug-and-Play Algorithm with Guaranteed Convergence: Applications to Data Fusion in Imaging

The recently proposed plug-and-play (PnP) framework allows leveraging recent developments in image denoising to tackle other, more involved, imaging inverse problems. In a PnP method, a black-box denoiser is plugged into an iterative algorithm, taking the place of a formal denoising step that corresponds to the proximity operator of some convex regularizer. While this approach offers flexibility and excellent performance, convergence of the resulting algorithm may be hard to analyze, as most state-of-the-art denoisers lack an explicit underlying objective function. In this paper, we propose a PnP approach where a scene-adapted prior (i.e., where the denoiser is targeted to the specific scene being imaged) is plugged into ADMM (alternating direction method of multipliers), and prove convergence of the resulting algorithm. Finally, we apply the proposed framework in two different imaging inverse problems: hyperspectral sharpening/fusion and image deblurring from blurred/noisy image pairs.
Factors Influencing the Dividend Policy of Vietnamese Enterprises

The article explores the factors affecting company’s dividend policy such as profitability, firm size, financial leverage and growth rate. Data is collected from enterprises listed on the Vietnam securities market in the period of 2006 - 2017 with 2,150 observations. Using the Generalized Least Squares (GLS), the authors have identified two factors that have a positive and significant effect: (i) return on total assets and (ii) firm size. At the same time, research results also show a negative impact of enterprise’s revenue growth rate on the dividend payment ratio. In addition, financial leverage has no impact on company’s dividend policy.
Traumatic aneurysm resulting from insertion of an intracranial pressure monitor. Case illustration.

bolt; Codman, Raynham, MA) was placed through a twist-drill hole into the right frontal region of a 30-year-old man who had sustained a severe, closed head injury. The dura mater was opened using an 18-gauge needle and the monitor was inserted without any obvious bleeding. The monitor was removed 7 days later. A cranial computerized tomography (CT) scan obtained several hours postinjury did not reveal skull fracture or hematoma in the right frontal area, and a magnetic resonance (MR) image obtained 17 days postinjury did not demonstrate any hemorrhage at the site where the monitor had been placed (Fig. 1 left; arrow). The patient was transferred to our hospital for further care. A routine CT scan obtained 25 days postinjury revealed the presence of intraparenchymal hemorrhage beginning at the site of monitor insertion and extending down into the lateral ventricle (Fig. 1 center). There was no change in the patient’s clinical condition. Angiography demonstrated a 3-mm-wide fusiform aneurysm arising from a cortical branch of the right anterior cerebral artery (ACA) immediately underneath the twist-drill hole (Fig. 1 right; arrow). The aneurysm was excised via a small craniotomy, and the hematoma was evacuated. Histopathological examination of the aneurysm revealed complete disruption of all three layers of the arterial wall and a false aneurysm (the wall of which consisted of fibrous tissue) arising from the torn edges and blending into a large hematoma with chronic inflammation, hemosiderin-laden macrophages, and decaying blood products (Fig. 2). The degree of fibrous tissue formation was consistent with the aneurysm’s arising at the time of monitor insertion. Most cases of iatrogenic aneurysm present with intracranial hemorrhage (ICH), although 20% have been discovered incidently and 30% after various other symptoms or because vascular injury was suspected in the absence of hemorrhage.1,2 Intracranial hemorrhage at the time of the inciting event has only been noted in two thirds of cases.1,2 Postoperative hemorrhage leading to diagnosis has occurred, on average, 81 days later, if a single case presenting 16 years later is excluded. The reported mortality rate is 14%. 1,2 The inciting pathophysiological event is direct injury to one or more layers of the arterial wall. We postulate that in the present case, the needle used to open the dura mater or the ICP monitor itself lacerated all layers of the arterial wall. The lack of obvious bleeding at the time of monitor placement may indicate that the monitor itself tore the artery and then partly occluded the tear, stopping the bleeding. This case documents a previously undescribed complication of ICP monitor placement and supports the need for angiography in patients who display delayed ICH after head injury.