Miracle-dz/UniFAR-FTUs huggingface dataset:
Cross‐modal sensory processing in the anterior cingulate and medial prefrontal cortices

One of the principal functions of the nervous system is to synthesize information from multiple sensory channels into a coherent behavioral and perceptual gestalt. A critical feature of this multisensory synthesis is the sorting and coupling of information derived from the same event. One of the singular features of stimuli conveying such information is their contextual or semantic congruence. Illustrating this fact, subjects are typically faster and more accurate when performing tasks that include congruent compared to incongruent cross‐modal stimuli. Using functional magnetic resonance imaging, we demonstrate that activity in select brain areas is sensitive to the contextual congruence among cross‐modal cues and to task difficulty. The anterior cingulate gyrus and adjacent medial prefrontal cortices showed significantly greater activity when visual and auditory stimuli were contextually congruent (i.e., matching) than when they were nonmatching. Although activity in these regions was also dependent on task difficulty, showing decreased activity with decreasing task difficulty, the activity changes associated with stimulus congruence predominated. Hum. Brain Mapping 19:213–223, 2003. © 2003 Wiley‐Liss, Inc.
On the Effectiveness of Least Squares Generative Adversarial Networks

Unsupervised learning with generative adversarial networks (GANs) has proven to be hugely successful. Regular GANs hypothesize the discriminator as a classifier with the sigmoid cross entropy loss function. However, we found that this loss function may lead to the vanishing gradients problem during the learning process. To overcome such a problem, we propose in this paper the Least Squares Generative Adversarial Networks (LSGANs) which adopt the least squares loss for both the discriminator and the generator. We show that minimizing the objective function of LSGAN yields minimizing the Pearson <inline-formula><tex-math notation="LaTeX">$\chi ^2$</tex-math><alternatives><mml:math><mml:msup><mml:mi>χ</mml:mi><mml:mn>2</mml:mn></mml:msup></mml:math><inline-graphic xlink:href="mao-ieq1-2872043.gif"/></alternatives></inline-formula> divergence. We also show that the derived objective function that yields minimizing the Pearson <inline-formula><tex-math notation="LaTeX">$\chi ^2$</tex-math><alternatives><mml:math><mml:msup><mml:mi>χ</mml:mi><mml:mn>2</mml:mn></mml:msup></mml:math><inline-graphic xlink:href="mao-ieq2-2872043.gif"/></alternatives></inline-formula> divergence performs better than the classical one of using least squares for classification. There are two benefits of LSGANs over regular GANs. First, LSGANs are able to generate higher quality images than regular GANs. Second, LSGANs perform more stably during the learning process. For evaluating the image quality, we conduct both qualitative and quantitative experiments, and the experimental results show that LSGANs can generate higher quality images than regular GANs. Furthermore, we evaluate the stability of LSGANs in two groups. One is to compare between LSGANs and regular GANs without gradient penalty. We conduct three experiments, including Gaussian mixture distribution, difficult architectures, and a newly proposed method — datasets with small variability, to illustrate the stability of LSGANs. The other one is to compare between LSGANs with gradient penalty (LSGANs-GP) and WGANs with gradient penalty (WGANs-GP). The experimental results show that LSGANs-GP succeed in training for all the difficult architectures used in WGANs-GP, including 101-layer ResNet.
The Development of “Pro-Life” NGOs in Argentina: Three Strategic Movements

In Latin America, the agenda of sexual and reproductive rights advocated by the feminist and LGBTI movements has challenged the hegemony of the sexual order held by traditionalist sectors, especially the hierarchy of the Catholic Church and conservative evangelical churches. These religious groups have reacted, in turn, to arrest the advance of feminist and LGBTI agendas. Beyond conservative Catholic and evangelical hierarchies, opposition activists also include religious academic institutions, politicians, Christian lay movements, and civil society groups, among others, all committed to a more restrictive view of sexuality. One important strategy of this ‘Pro-Life’ activism in recent years has been the conformation of non governmental organizations (NGOs). This article offers an analysis of the emergence and development of ‘Pro-Life’ NGOs in Argentina. Using both quantitative and qualitative data, it examines three strategic movements made by these NGOs from the 1980s to the present: a state-political turn that favored strategies aimed to colonize the state and to impact sexual policies and the law; a blurring of religious identities; and a process of federalization and civil ecumenism.
What's driving innovation in small businesses in Australia? The case of the food industry†

There is strong evidence that innovation is a primary driver of a nation's economic growth. As Australia continues to compete in the global economy, it is imperative that businesses should be innovative to improve their performance. In this paper, we evaluate the status and main drivers of innovation in small businesses in the food sector in Australia. Discrete choice modelling and bootstrapping procedures are applied to a panel of firm‐level data collected through the ABS Business Characteristics Survey (2006–2007 to 2010–2011 for the Australian Bureau of Statistics’ Business Longitudinal Database Confidential Unit Record File) to investigate the factors affecting the likelihood of small food businesses to innovate. Results show that businesses are more likely to innovate if they collaborate, have higher information and communication technology intensity, and use science, technology, engineering and mathematics skills. We also found that small food businesses, even at the subsector level, do combine different types of innovation when innovating. The propensity to innovate also increases for small businesses that have flexible working arrangements, face moderate‐to‐strong market competition, operate overseas and seek finance through debt and equity. The relative importance of these factors was found to vary between agricultural and nonagricultural food subsectors.
Cortical speech and non‐speech discrimination in relation to cognitive measures in preschool children

Effective speech sound discrimination at preschool age is known to be a prerequisite for the development of language skills and later literacy acquisition. However, the speech specificity of cortical discrimination skills in small children is currently not known, as previous research has either studied speech functions without comparison with non‐speech sounds, or used much simpler sounds such as harmonic or sinusoidal tones as control stimuli. We investigated the cortical discrimination of five syllable features (consonant, vowel, vowel duration, fundamental frequency, and intensity), covering both segmental and prosodic phonetic changes, and their acoustically matched non‐speech counterparts in 63 6‐year‐old typically developed children, by using a multi‐feature mismatch negativity (MMN) paradigm. Each of the five investigated features elicited a unique pattern of differentiating negativities: an early differentiating negativity, MMN, and a late differentiating negativity. All five studied features showed speech‐related enhancement of at least one of these responses, suggesting experience‐related neural commitment in both phonetic and prosodic speech processing. In addition, the cognitive performance and language skills of the children were tested extensively. The speech‐related neural enhancement was positively associated with the level of performance in several neurocognitive tasks, indicating a relationship between successful establishment of cortical memory traces for speech and enhanced cognitive functioning. The results contribute to the understanding of typical developmental trajectories of linguistic vs. non‐linguistic auditory skills, and provide a reference for future studies investigating deficits in language‐related disorders at preschool age.
The genetic landscape of endometrial clear cell carcinomas

Clear cell carcinoma of the endometrium is a rare type of endometrial cancer that is generally associated with an aggressive clinical behaviour. Here, we sought to define the repertoire of somatic genetic alterations in endometrial clear cell carcinomas (ECCs), and whether ECCs could be classified into the molecular subtypes described for endometrial endometrioid and serous carcinomas. We performed a rigorous histopathological review, immunohistochemical analysis and massively parallel sequencing targeting 300 cancer‐related genes of 32 pure ECCs. Eleven (34%), seven (22%) and six (19%) ECCs showed abnormal expression patterns for p53, ARID1A, and at least one DNA mismatch repair (MMR) protein, respectively. Targeted sequencing data were obtained from 30 of the 32 ECCs included in this study, and these revealed that two ECCs (7%) were ultramutated and harboured mutations affecting the exonuclease domain of POLE. In POLE wild‐type ECCs, TP53 (46%), PIK3CA (36%), PPP2R1A (36%), FBXW7 (25%), ARID1A (21%), PIK3R1 (18%) and SPOP (18%) were the genes most commonly affected by mutations; 18% and 11% harboured CCNE1 and ERBB2 amplifications, respectively, and 11% showed DAXX homozygous deletions. ECCs less frequently harboured mutations affecting CTNNB1 and PTEN but more frequently harboured PPP2R1A and TP53 mutations than non‐POLE endometrioid carcinomas from The Cancer Genome Atlas (TCGA). Compared to endometrial serous carcinomas (TCGA), ECCs less frequently harboured TP53 mutations. When a surrogate model for the molecular‐based TCGA classification was used, all molecular subtypes previously identified in endometrial endometrioid and serous carcinomas were present in the ECCs studied, including POLE, MMR‐deficient, copy‐number high (serous‐like)/p53 abnormal, and copy‐number low (endometrioid)/p53 wild‐type, which were significantly associated with disease‐free survival in univariate analysis. These findings demonstrate that ECCs constitute a histologically and genetically heterogeneous group of tumours with varying outcomes. Furthermore, our data suggest that the classification of ECCs as being generally ‘high‐grade’ or ‘type II’ tumours may not be warranted. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Administration of β‐glucan following Leishmania major infection suppresses disease progression in mice

Summary The potential of β‐glucan (glucan) to suppress the progression of lesions caused by virulent strains of Leishmania major in genetically susceptible BALB/c mice when administered post challenge was evaluated. Glucan particles (glucanp) prepared from Saccharomyces cerevisiae were injected i.v. at 7‐day intervals starlins 7 days after parasite challenge. Four injections gave a more rapid and a higher extent of suppression than 1, 2 or 3 injections. Mice receiving only parasites, a glucose solution, starch particles or glucanp by the i.p. route showed a progressive increase in footpad thickness and developed ulcerating lesions. An alkali solubilized glucan (glucanas) was injected (50 μg, 200 μg and 400 μg/mousc) 4 times at 4 day intervals either i.v. or i.p. starling four days post parasite challenge. Glucanas injection by either route blocked lesion development; the 50 μg treatment had already substantial effects and 400 μg in the i.p. route prevented even the initial stages of lesion formation. Touch prints from the lesion area and from the liver of mice receiving 200 μg glucanas were amasiigote free. The anti Leishmania antibody litre of glucanas treated mice was lower and their sera recognized fewer antigens than that of control Leishmania bearing mice.
International organizations and democracy : accountability, politics, and power

Do international organizations represent the interests of the global citizenry? Or are they merely vehicles for the agendas of powerful nations and special interests? Thomas Zweifel explores this increasingly contentious issue, deftly blending history, theory, and case studies. Zweifel's analysis covers both regional organizations (e.g., the EU, NAFTA, NATO, the AU) and such global institutions as the United Nations, the World Bank, and the World Trade Organization. With international organizations becoming perhaps the most appropriate-if not the only-forum for tackling myriad transnational challenges, his systematic study of how these organizations function is central to the study of both international relations and democracy in the 21st century.
Corporate Social Irresponsibility and Purchase Intention

An important objective of business research is to understand how organizational practices can influence consumer attitude and behaviors in order to help achieve organizational goals via consumer purchase intention. It was proposed and found in this study that consumers’ perceptions of certain Corporate Social Irresponsible (CSI) practices serves as antecedents of consumer purchase intention (PI) via corporate reputation (CR) and consumer attitude (CA). On the one hand, this finding may help understand the “black box” between CSI practices and PI. On the other hand, while CR refers to customers’ evaluations of the reputation of the organization and CSI represent a significant channel the organization uses to channel its irresponsible behavior to the community, CR and CA literatures have not comprehensively examined the effect of CSI practices on consumers CA and CR beliefs. The findings in the hierarchical regression from a sample of 455 consumers of products in a large corporate organization in Kenya as a study documenting a negative association between CSI practices and CR and CA with PI suggests that consumers draw inferences from the CSI-related treatment they receive in assessing the supportiveness of the organization. By implementing CSI practices that demonstrate the organization does not care about the community and values their contribution, organizations are likely to be perceived as engaging in a high level of irresponsible behaviour. The results of this study add to our knowledge about the antecedents of CR and CA. Moreover, this study bridges the gap in the literature, by combining CSI, CR, CA and PI.
Gender-Specific Risk Factors for Intimate Partner Homicide

The present study examined gender differences in intimate partner homicide (IPH) and offender characteristics with the focus on putative gender-specific risk factors in a nationwide consecutive sample of homicide offenders. Data on all offenders (N = 642; 91 females, 551 males) convicted of homicide and subjected to a forensic psychiatric examination in Finland were obtained for the years 1995 and 2004. IPH offenders, 39 female and 106 male, were compared for risk factors with female and male offenders whose victims were not spouses. The forensic psychiatric examination reports were retrospectively analyzed, and the Hare Psychopathy Checklist–Revised (PCL-R) was rated. Significant gender differences were found in four risk factors: employment, intoxication of victim, self-defense, and quarrel, mostly related to alcohol as a factor of the offense. The findings support the notion that female IPH is linked to defensive reactions resulting from prior abuse, and that IPH offenders resemble the general population more than offenders of other types of homicide.
B Cells Secrete Eotaxin-1 in Human Inflammatory Bowel Disease

Background:Our previous studies have demonstrated that B cells in human inflammatory bowel disease (IBD) are highly activated and produce copious amounts of chemokines. Here, we showed that B cells produce eotaxin-1, a selective chemokine for acute eosinophilia. Increased levels of activated eosinophils have been found in the intestinal mucosa in patients with IBD, but their role(s) and the regulation of their migration patterns remain poorly defined. Methods:To determine how B-cell secretion of eotaxin-1 influences eosinophil activation and migration, we performed immunoepidemiological approaches coupled with in vitro studies. B cells and eosinophils from patients with Crohn’s disease and ulcerative colitis were isolated, and responses to Toll-like receptor ligands (TLR) were measured and assessed for the relationship with clinical disease. Results:Eotaxin-1 from recirculating B cells, and TLR ligands, regulated eosinophil homing mechanisms in IBD. B cells stimulated with hypo-acylated lipopolysaccharide (LPS) produced copious amounts of eotaxin-1, which influenced eosinophil activation profiles in the bloodstream. We also found that hexa-acylated LPS, such Escherichia coli LPS, directly activated TLR2-expressing and TLR4-expressing eosinophils from patients with IBD to express a different repertoire of mucosal homing receptors, namely CCR9 and CCR10. Whereas B-cell production of eotaxin-1 was correlated with reduced disease activity, eosinophil activation by hexa-acylated LPS was associated with increased disease activity. Conclusions:These results suggest that systemic TLR ligands influence eosinophil migration patterns, both directly and indirectly, through B cells. Our report uncovers unexpected mechanisms of cross talk between certain immune cells that shed new light on IBD immunology.
Role of nitric oxide in the regulation of the mechanical properties of peripheral conduit arteries in humans.

Whether nitric oxide (NO) contributes to the regulation of the mechanical properties of large arteries in humans is not known. We measured the effect of local administration of the inhibitor of NO synthesis N(G)-monomethyl-L-arginine (L-NMMA; 1 and 4 micromol x L[-1] x min[-1] for 5 minutes) and acetylcholine (3 and 30 nmol x L[-1] x min[-1] for 3 minutes) on radial artery diameter and wall thickness in 11 healthy volunteers using an echo-tracking system coupled to a measurement of radial blood flow (Doppler) and arterial pressure. At the highest dose, L-NMMA reduced radial blood flow but surprisingly decreased incremental elastic modulus (from 1.36+/-0.22 to 1.00+/-0.22 kPa x 10[3]; P<.05) and increased arterial compliance (from 3.20+/-0.46 to 4.07+/-0.45 m2 x kPa x 10(-8), P<. 05), without affecting radial artery internal diameter, wall thickness or midwall stress, thus reflecting a decrease in vascular tone. Acetylcholine decreased incremental elastic modulus (from 1.27+/-0.08 to 0.88+/-0.07 kPa x 10[3]; P<.05) and increased arterial diameter, radial blood flow, and compliance (from 2.82+/-0.16 to 5.30+/-0.62m2 x kPa x 10[-8]; P<.05). These results demonstrate in vivo that NO is involved in the regulation of the mechanical properties of large arteries in humans. However, the effects of L-NMMA, ie, a decrease in arterial wall rigidity and an increase in arterial compliance, which occur in the absence of any changes in blood pressure or arterial geometry, suggest that inhibition of NO synthesis is associated in humans with a paradoxical isometric smooth muscle relaxation. This effect could be due to the development of compensatory vasodilating mechanisms after NO synthesis inhibition.
EVOLUTION OF ASPM IS ASSOCIATED WITH BOTH INCREASES AND DECREASES IN BRAIN SIZE IN PRIMATES

A fundamental trend during primate evolution has been the expansion of brain size. However, this trend was reversed in the Callitrichidae (marmosets and tamarins), which have secondarily evolved smaller brains associated with a reduction in body size. The recent pursuit of the genetic basis of brain size evolution has largely focused on episodes of brain expansion, but new insights may be gained by investigating episodes of brain size reduction. Previous results suggest two genes (ASPM and CDK5RAP2) associated with microcephaly, a human neurodevelopmental disorder, may have an evolutionary function in primate brain expansion. Here we use new sequences encoding key functional domains from 12 species of callitrichids to show that positive selection has acted on ASPM across callitrichid evolution and the rate of ASPM evolution is significantly negatively correlated with callitrichid brain size, whereas the evolution of CDK5RAP2 shows no correlation with brain size. Our findings strongly suggest that ASPM has a previously unsuspected role in the evolution of small brains in primates. ASPM is therefore intimately linked to both evolutionary increases and decreases in brain size in anthropoids and is a key target for natural selection acting on brain size.
Mechanisms of Zn2+ efflux in cultured cortical neurons

Zinc dyshomeostasis in brain might be involved in the pathogenesis of brain diseases such as Alzheimer’s disease and stroke. Resting neurons tightly regulate and maintain low to subnanomolar levels of intracellular free Zn2+, but mechanisms of normal Zn2+ homeostasis are poorly understood. In this study, the mechanisms of transporter‐mediated Zn2+ extrusion across the plasma membrane of cultured cortical neurons were studied. Changes in intracellular free Zn2+ levels were tracked in individual neurons by microfluorometry using a Zn2+ selective fluorophore, FluoZin3. Unopposed Zn2+ efflux was measured by first loading cultured cortical neurons with Zn2+ then reducing extracellular Zn2+ to near zero by addition of EDTA. Studies revealed that the primary means of Zn2+ efflux in cortical neurons required both extracellular Na+ and Ca2+. The actions of either Na+ or Ca2+ on Zn2+ efflux were blunted in the absence of the other cation. Reversed Na+ gradients could induce Zn2+ uptake. The Na+ dependence of Zn2+ efflux was not affected by a small pHo shift (7.6–8); whereas an effect of Ca2+ was not observed at pHo 8. In summary, a Na+, Ca2+/Zn2+ exchanger mechanism is proposed to be the primary transport mechanism that extrudes Zn2+ when neuronal intracellular free Zn2+ levels rise.
Campylobacter jejuni in broilers: the role of vertical transmission

SUMMARY The role of broiler eggs in the transmission of Campylobacter jejuni to broiler grow-out flocks was investigated. Six breeder flocks supplying broiler eggs to hatcheries were examined for cloacal carriage of C. jejuni. Of 240 birds tested, 178 (74%) were C. jejuni-positive. Eggs from these birds examined for C. jejuni penetration of the egg shell indicated that 185 of 187 were campylobacter-free. Eggs from breeder flocks of unknown C. jejuni status were also examined for C. jejuni shell penetration. C. jejuni was not isolated from 142 eggs examined. A further 193 hatchery eggs incubated and hatched in the laboratory were campylobacter-free. Six farms containing the progeny of C. jejuni-positive breeder flocks were monitored. Eight hundred and forty birds from 14 flocks m these grow-out farms were campylobacter-free during their 6-week grow-out period. Experimental egg-penetration studies indicated that C. jejuni transmission via the egg is not easily effected. Of 257 eggs surface-challenged with C. jejuni, 162 hatched; all were campylobacter-free. Of 167 eggs injected with C. jejuni, 12 hatched; 2 of these were colonized with C. jejuni. Our data do not support a role for vertical transmission of C. jejuni in commercial broiler production.
In Vitro Activities of Ketolide HMR 3647, Macrolides, and Clindamycin against Coryneform Bacteria

ABSTRACT The in vitro activity of ketolide HMR 3647 against coryneform bacteria isolated from clinical samples was evaluated. Except againstCorynebacterium jeikeium and C. urealyticum, HMR 3647 showed high activity againstCorynebacterium spp. , being more active than 14- and 16-membered macrolides, azithromycin, or clindamycin. HMR 3647 also had high in vitro activity against Brevibacterium spp. andListeria monocytogenes.