Miracle-dz/UniFAR-FTUs huggingface dataset:
Message scheduling and timing analysis for flexray dynamic segment by considering slot-multiplexing

FlexRay is a communication protocol that combines event- and time-triggered communication to increase the schedulability and flexibility of message scheduling in current car systems. Because safety and reliability are particularly crucial for automotive systems, the worst-case response times of signals transmitted by electronic control units must be under their deadlines. To increase the bandwidth utilization, the slotmultiplexing (SM) mechanism that is allowable in protocol specification was adopted to schedule messages offline in the dynamic segment of the FlexRay protocol, and this mechanism was also considered in the timing analysis. The proposed method was feasible to calculate worst-case response time of message under any bus load when considered slot-multiplexing. Then the approach was applied to a Society of Automotive Engineers benchmark to ensure that all messages were schedulable. The simulation results revealed that by using slot-multiplexing, only 17 identifiers were used, which was less than 23 identifiers that were needed when the slot-multiplexing was not considered. It also improved the schedulability of dynamic segment with up to 27% improvement in bus bandwidth utilization.
Total phenolic content, in vitro antioxidant activity and type II diabetes relevant enzyme inhibition properties of methanolic extract of traditionally processed underutilized food legume, Acacia nilotica (L.) Willd ex. Delile.

The methanolic extract of Acacia nilotica (L.) Willd ex. Delile (black thorn tree) seed materials, an underutilized food legume collected from India was found to contain total free phenolic content of 14.57 ± 1.69 g catechin equivalent/100 g extract DM. Encouraging levels of ferric reducing/antioxidant power (FRAP, 1840 mmol Fe[II]/mg extract), inhibition of ß-carotene degradation (53.26%) and radical scavenging activity against DPPH (64.91%) and superoxide (53.23%) radicals were noticed. Further, it also recorded 72.91% of α-amylase and 65.13% of α-glucosidase enzyme inhibition characteristics. Sprouting + oil-frying caused a apparent increase on the total free phenolic content and also significant improvement on the antioxidant and free radical scavenging capacity of methanolic extract of A. nilotica seeds, while soaking + cooking as well as open-pan roasting treatments showed diminishing effects. Moreover, inhibition of α-amylase and α-glucosidase enzyme activities was declined to 22.47 and 46.13%, respectively during sprouting + oil-frying treatment, which are more desirable for the dietary management of type II diabetes.
Both silicalite-1/SiC foam and ZSM-5/SiC foam may serve as novel bone replacement materials.

Background This study aimed to analyze the bioactivity and biocompatibility of silicon carbide (SiC) foam coated with one of two kinds of zeolite. Methods The surface charges, protein adsorption ability and mineralization ability were compared between silicalite-1/SiC foam and ZSM-5/SiC foam. Results Proliferation and differentiation of primary osteoblasts seeded on two types of materials were significantly higher when compared with uncoated SiC foam after 7 d. There was no significant difference in the bioactivity between silicalite-1/SiC foam and ZSM-5/SiC foam. Silicalite-1/SiC foam and ZSM-5/SiC foam had no cytotoxic effect on primary osteoblasts. Conclusions These results suggest both silicalite-1/SiC foam and ZSM-5/SiC foam have the potential for use as novel bone replacement materials.
Incidence of inhibitors in a cohort of 838 males with hemophilia A previously treated with factor VIII concentrates

Summary. Background: Development of an inhibitory antibody to factor VIII is currently the most serious complication of hemophilia A treatment. The rate of inhibitor development in those that have been previously treated with factor concentrates is poorly defined. Understanding the baseline rate of inhibitor development in the population of previously treated patients (PTPs) is important when evaluating the effect of exposure to new factor replacement products on inhibitor formation. Objectives: To determine the rate of inhibitor development in PTPs with hemophilia A. Methods: A cohort of males with hemophilia A who had data collected on four or more occasions prior to 30 March 2003, as part of the Center for Disease Control and Prevention's Universal Data Collection Project, were eligible for inclusion in the cohort. Patients were included in the cohort if they had at least two Bethesda assay measurements and did not have an inhibitor prior to or at the start of the study period. The overall incidence rate was estimated as the number of verified incident inhibitor cases divided by the total follow‐up time in years multiplied by 1000 (cases per 1000 person‐years). Results: A total of 838 patients were included in the study. The overall incidence rate was calculated to be 2.14 cases per 1000 person years. All incident cases had more than 50 exposure days prior to inhibitor development. Conclusions: Given the low rate of inhibitor development in PTPs with hemophilia A, small, non‐randomized studies are inadequate to determine the rate of inhibitor development after exposure to novel products. Ongoing, standardized, postmarketing surveillance is needed to determine if novel factor products pose an increased risk of inhibitor development.
Long-term cultures of testicular biopsies from boys with cryptorchidism: effect of FSH and LH on the number of germ cells.

BACKGROUND A long-term culture system of testicular biopsies from boys with undescended testes was established to evaluate the effect of gonadotrophins on germ cell survival and growth. METHODS Biopsies from 25 boys with cryptorchidism, aged 1.1-9.9 years, were obtained at the time of surgery. Each biopsy was subdivided into fragments and cultured for 1 or 3 weeks in a testis culture medium without gonadotrophins or supplemented with FSH (50 IU/l) or LH (5 IU/l), or a combination of FSH (50 IU/l) plus LH (5 IU/l). The survival of the germ cells was evaluated by calculating the ratio of spermatogonia and gonocytes per cross-sectioned testicular tubule, the S/T ratio. RESULTS All cultured fragments maintained their overall morphology. A significantly reduced S/T ratio was observed in the fragments cultured in the presence of LH (P = 0.006), independently of the culture period. The mean tubular diameter in fragments cultured for 1 week with hormones was significantly larger than that of the controls (P < 0.0002). All cultured fragments had a larger tubular diameter than the uncultured fragments (P = 0.0002). CONCLUSIONS This culture system supports survival of spermatogonia for at least 3 weeks. LH either alone or in combination with FSH results in a significantly reduced S/T ratio.
The Evolution of Inequality, Heterogeneity and Uncertainty in Labor Earnings in the U.S. Economy

A large empirical literature documents a rise in wage inequality in the American economy. It is silent on whether the increase in inequality is due to greater heterogeneity in the components of earnings that are predictable by agents or whether it is due to greater uncertainty faced by agents. Applying the methodology of Cunha, Heckman, and Navarro (2005) to data on agents making schooling decisions in different economic environments, we join choice data with earnings data to estimate the fraction of future earnings that is forecastable and how this fraction has changed over time. We find that both predictable and unpredictable components of earnings have increased in recent years. The increase in uncertainty is substantially greater for unskilled workers. For less skilled workers, roughly 60% of the increase in wage variability is due to uncertainty. For more skilled workers, only 8% of the increase in wage variability is due to uncertainty. Roughly 26% of the increase in the variance of returns to schooling is due to increased uncertainty. Using conventional measures of income inequality masks the contribution of rising uncertainty to the rise in the inequality of earnings for less educated groups.
A comprehensive study: Ant Colony Optimization (ACO) for facility layout problem

In context of manufacturing, numerous models are designed to appropriately represent the facility layout problem (FLP) and a variety of optimization methods have been applied to solve these models. The ultimate goal of these methods is to find optimal solutions, In regard to Swarm Intelligence (SI), Ant Colony Optimization (ACO) and Particle Swarm Optimization (PSO) are regarded as the most important SI techniques of our time. In this paper, a brief introduction for the so far most promising approaches to facility layout related topics, are provided. The succeeding paper will then illustrate some of those, in more detail. Moreover, we examine ACO modifications and extensions that could contribute to optimization methods in FLP; mostly conform to NP-hard combinatorial problems. future research areas are identified in Construction Site Facility Layout Problems, Multi-Criteria Facility Layout Problems and Dynamic Facility Layout Problems.
A Study of the Multilevel and Dynamic Nature of Trust in E-Commerce from a Cross-Stage Perspective

Trust in e-commerce is a multilevel construct (intrapersonal, system, and interpersonal), and trust building is a dynamic evolutionary process that can be adjusted over time when additional evidence of new interactions becomes available. From a consumer's perspective in a business-to-consumer e-commerce context, there are at least two trustees: the Internet as a shopping channel (the e-channel—system level) and an Internet selling party or Internet vendor (the e-vendor—interpersonal level) as a business partner. Understanding the multilevel and dynamic nature of trust in e-commerce is important because it not only provides practical insights that can be used to further enhance the online experiences for both online managers and consumers but also extends our conceptual foundations of trust. Although the multilevel and dynamic nature of trust is a crucial characteristic of trust in e-commerce, there is little empirical research. To fill this knowledge gap, this study proposes a multilevel model of e-channel and e-vendor trust, including trust propensity (intrapersonal level) from a cross-stage (pre- and postpurchase) perspective. This study also proposes a relatively new construct, the consumer's perceived delivery fulfillment in e-commerce. Implications of the findings for theory and practice as well as limitations and avenues for future study are discussed.
Malignant Change Arising in Tissues Affected by Herpes

mental and physical disabilities rendering future life nigh unbearable-were a nightmare to all who had the misfortune to participate in this phase of the management of tuberculous meningitis. Happily we are now rapidly passing to a more rational and infinitely more kindly treatment and are getting better results, as was shown by Smellie (1954). Yet some infants must inevitably succumb if they are involved in a progressive infection, whatever treatment they have, and, vaccination might well save these.
Model based method for electro-migration stress determination in interconnects

Electro-migration (EM) failure in interconnects is one of the most important reliability considerations in current advanced semiconductor technologies. As the technology features are pushed to the limit and with the introduction of new materials and increased current densities to satisfy the performance demands, the EM failure risk is ever-increasing. In this paper we present a novel methodology based on a model-based approach where EM risk can be assessed for any interconnect geometry through an exact solution of the fundamental stress equations. This approach eliminates the need for complex look-up tables for different geometries and can be implemented in CAD tools very easily.
Protein structure prediction and design in a biologically-realistic implicit membrane

Protein design is a powerful tool for elucidating mechanisms of function and engineering new therapeutics and nanotechnologies. While soluble protein design has advanced, membrane protein design remains challenging due to difficulties in modeling the lipid bilayer. In this work, we developed an implicit approach that captures the anisotropic structure, shape of water-filled pores, and nanoscale dimensions of membranes with different lipid compositions. The model improves performance in computational bench-marks against experimental targets including prediction of protein orientations in the bilayer, ΔΔG calculations, native structure dis-crimination, and native sequence recovery. When applied to de novo protein design, this approach designs sequences with an amino acid distribution near the native amino acid distribution in membrane proteins, overcoming a critical flaw in previous membrane models that were prone to generating leucine-rich designs. Further, the proteins designed in the new membrane model exhibit native-like features including interfacial aromatic side chains, hydrophobic lengths compatible with bilayer thickness, and polar pores. Our method advances high-resolution membrane protein structure prediction and design toward tackling key biological questions and engineering challenges. Significance Statement Membrane proteins participate in many life processes including transport, signaling, and catalysis. They constitute over 30% of all proteins and are targets for over 60% of pharmaceuticals. Computational design tools for membrane proteins will transform the interrogation of basic science questions such as membrane protein thermodynamics and the pipeline for engineering new therapeutics and nanotechnologies. Existing tools are either too expensive to compute or rely on manual design strategies. In this work, we developed a fast and accurate method for membrane protein design. The tool is available to the public and will accelerate the experimental design pipeline for membrane proteins.
Proposal for a synthetic lethality therapy using the paralog dependence of cancer cells--response.

We thank Dr. Thompson and colleagues for their insightful comments about our article ([1][1]). We have now reevaluated our finding based on their comments. Recently, two studies sought to identify synthetic lethal partners for BRG1 using the same (and other) cancer cell lines as used by us ([2, 3][
Predicting Cognitive Decline in Alzheimer Disease: Role of Platelet Amyloid Precursor Protein

An altered pattern of platelet amyloid precursor protein (APP) forms, consisting of a reduced ratio of the upper (130 kDa) to the lower (110 to 106 kDa) immunoreactivity band (APPr), is associated with Alzheimer disease (AD), although in the early stages of AD this pattern shows high variability. To explore whether APPr values at baseline may predict the rate of cognitive decline, we evaluated patients with mild AD before and after 1 year of treatment with acetylcholinesterase inhibitors. Lower APPr at baseline was the only predictor of progressive cognitive decline, suggesting that this biomarker might be a useful indicator of prognosis for patients with AD.
[Analysis on genetic polymorphism of mtDNA in endurance athletes and sedentary subjects].

AIM To analysis the sequence variation of the origin region (D-loop) of mitochondrial DNA (mtDNA) in elite endurance athletes and sedentary subjects in order to find the genetic markers related with performance. METHODS Using a new established PCR method by virtue of tracing sample analysis, the restricted fragment length polymorphism (RFLP) of D-loop in mtDNA was assessed in 76 elite Chinese endurance athletes (EEA), 33 endurance athletes with average-level(GEA) and 20 sedentary control(sc). RESULTS There is a significant difference in distribution of the polymorphism in mtDNA D-loop between the EEA and SC(chi 2 = 33.3, P < 0.01). CONCLUSION The sequence variation of D-loop region of mtDNA in the elite endurance athletes may contribute to the individual difference in aerobic performance and trainability.
Primary Bone Tumor of the Spine—An Evolving Field: What a General Spine Surgeon Should Know

Study Design: A narrative review of the literature. Objective: This article reviews the general principles of treatment and investigation for primary bone tumors of the spine. Furthermore, it explores the emerging alternatives. Methods: A review was performed using Medline, Embase, and Cochrane databases. Results: Primary bone tumors of the spine are rare entities that general spine surgeons may encounter only a few times in their career. The treatment algorithm of these complex tumors is filled with nuances and is evolving constantly. For these reasons, patients should be referred to experienced tertiary or quaternary centers who can offer a comprehensive multidisciplinary approach. For most malignant spinal bone tumors, surgery remains the cornerstone of treatment. Respecting oncologic principles has been associated with improved survival and decreased local recurrence in multiple settings. However, even in experienced centers, these surgeries carry a significant risk of adverse events and possible long-term neurologic impairment. The associated morbidity of these procedures and the challenges of local recurrence have encouraged professionals caring for these patients to explore alternatives or adjuncts to surgical treatment. Conclusions: Over the past few years, several advances have occurred in medical oncology, radiation oncology and interventional radiology, changing the treatment paradigm for some tumors. Other advances still need to be refined before being applied in a clinical setting.
Magnetic Sensor Used to Detect Contamination of Insulating Oil in Motors Applied to Electrical Submersible Pump

This paper presents a solution for detecting contamination of insulating oil used in the artificial lift method of the oil-type electrical submersible pump (ESP), which indirectly protects the induction motor associated with that system. The objective of this sensor is to generate an alarm signal at just the moment when the contamination in the isolated oil is present. The prototype was designed to work in harsh conditions to reach a depth of 2000 m and temperatures up to 200°C. It used simulator software to define the mechanical and electromagnetic variables. Results of field experiments were performed to validate the prototype. The final results performed in an ESP system with a 60-HP motor showed a good reliability and fast response of the prototype.
BACTERIAL PILI Architecture of the type IVa pilus machine

INTRODUCTION: Type IVa pili are bacterial cell surface structures that perform critical functions in motility, surface adhesion, virulence, and biofilm formation. Type IVa pili are anchored in the cell envelope and pull cells forward through cycles of extension, adhesion to surfaces, and retraction, all powered by the type IVa pilus machine (T4PM). Although the structures and connectivities of the 10 core T4PM proteins and minor pilins have already been determined, the overall architecture of the T4PM and its extension and retraction mechanisms have not.
Local Stabilizability of Nonlinear Control Systems

Introduction and some notations - general framework: statement of the problem motivations and examples definitions linear systems the linearization approach obstructions to stabilizability controllability and stabilizability. The Liapunov's direct method: Artstein's theorem the Jurdjevic-Quinn approach asymptotic controllability homogeneous systems bilinear systems - constant feedback stabilization. Indirect approaches: local approximation critical cases - the Center Manifold approach cascade systems exact and partial linearization minimum phase systems. Low-dimensional systems.
Inverse Determination of Coupling of Modes Parameters of Surface Acoustic Wave Resonators

Extraction of coupling of modes (COM) parameters from the manufacturing process of a surface acoustic wave device (SAW) is important in practice. In this study, we employed an inverse algorithm to recover the COM parameters from the measured admittance of a one-port SAW resonator. For completeness, the COM equations, the P-matrix representation and the related COM parameters have been summarized. The admittance of a one-port resonator was derived based on the P-matrix representation. One-port and two-port SAW resonator filters were fabricated and the related responses were measured. The simplex method was then used to determine the COM parameters inversely. The recovered COM parameters of the one-port SAW resonator have been demonstrated to be applicable to simulate not only the frequency response of the one-port SAW resonator but also that of the two-port one.
Psoriasis arthropathica associated with severe obesity showing high serum leptin level

Dear Editor, A 47-year-old man was seen in November 2002 for scaly erythema on the scalp. Three months later, scaly erythema also appeared on the abdomen and gradually spread to the whole body. His father and brother had been diagnosed with psoriasis vulgaris, and he had been diagnosed with hypertension. He and his brother had a body mass index (BMI) of 42.9 and 50.7 kg/m, respectively, and were severely obese. He had multiple erythema with white to silver scales on the back (Fig. 1a), abdomen (Fig. 1b) and extremities. Skin biopsy from the scaly erythema on the upper arm (Fig. 1c) disclosed hyperkeratosis with parakeratosis and elongation of rete ridges (Fig. 2a). In the papillary dermis and partially in the epidermis, there was an infiltration of lymphocytes, mixed with neutrophils, and a subcorneal microabscess (Fig. 2b). General laboratory data showed no particular abnormalities including glucose, glycohemoglobin A1c, total cholesterol and triglyceride except for a slightly elevated level of C-reactive protein (CRP; 0.6 mg/ dL). Serum leptin levels of our patient and his brother were high (20.2 and 28.1 ng/mL, respectively; normal, <5.2 ng/mL). He was diagnosed with psoriasis vulgaris and his Psoriasis Area and Severity Index (PASI) score was 15. He was treated with topical corticosteroid (mometasone furoate) and vitamin D3 (maxacalcitol), resulting in improvement of the skin lesions. When he was 49 years old, he suffered from arthralgia on the fingers and elbows. The distal interphalangeal joints of his right fingers swelled, and the CRP level rose to 5.0 mg/dL. Rheumatoid factor was negative. Thus, he was diagnosed with psoriasis arthropathica and treated with 8 mg/week of methotrexate, resulting in soothing of the arthralgia and a decline in the CRP level (1.0 mg/dL). Obesity is a significant risk factor for psoriasis and BMI is correlated with the severity of the disease. Naldi et al. disclosed that a moderately increased BMI (26–29 kg/m) was associated with a slightly