Miracle-dz/UniFAR-FTUs huggingface dataset:
Understanding soft and hard breakdown statistics, prevalence ratios and energy dissipation during breakdown runaway

Since some MOS digital circuits could remain functional after gate oxide breakdown (BD) provided that the post-BD resistance is high enough (1), the separate consideration of soft (SBD) and hard (HBD) breakdown events is necessary to set up an adequate application-specific reliability assessment methodology. In this work we deal with two relevant issues related to this problem. First, we study the statistics of SBD and HBD and their relation to the first-event BD statistical distribution as a function of their prevalence ratios. Second, we consider the modeling of the BD runaway as a means to determine these prevalence ratios as a function of stress conditions and device geometry.
Effects of socioeconomic and clinical factors on survival in multiple myeloma.

It was recently reported that low socioeconomic status (SES) in multiple myeloma (MM) patients is associated with a poorer prognosis. To reassess this finding in another group of MM patients, we used data from interviews of 153 MM patients seen at Duke University Medical Center over a 6-year period. Medical records were also reviewed for data on traditional clinical prognostic factors. Using proportional hazard survival analysis, no SES variables were associated with survival. Current income, highest income, occupation, type of dwelling, years of education, and crowding did not enter the stepwise regression model at alpha = . 10. In contrast, many clinical factors predicted prognosis (calcium, P = .019; percent plasma cells on initial bone marrow, P = .019; history of transfusions, P = .015; WBC count, P = .007; pathologic fractures, P = .001; and urate, P less than .001). Thus, we do not confirm the previously reported association between social class and myeloma survival.
Perceived Versus Actual Complexity for Websites: Their Relationship to Consumer Satisfaction

This article aims to further the understanding of how visual and decision-making complexities in websites impact the subjective experiences individuals have as they traverse them. More specifically, we attempt to understand subtle yet important differences in how consumers perceive complexity of a website and how that perception then impacts their satisfaction and liking of that website across two different types of products, hedonic and utilitarian. The most important contribution of this article is the idea that complexity per se is not simply a perceptual phenomenon but is also governed by situational and contextual factors. In essence, the subjective outcomes of satisfaction and liking that individuals experience as a result of variations in degrees of complexity of websites, though difficult to predict, can be managed with careful target marketing.
Evidence for evolutionary shifts in the fitness landscape of human complex traits

Selection alters human genetic variation, but the evolutionary mechanisms shaping complex traits and the extent of selection’s impact on polygenic trait evolution remain largely unknown. Here, we develop a novel polygenic selection inference method (Polygenic Ancestral Selection Test Encompassing Linkage, or PASTEL) relying on GWAS summary data from a single population. We use model-based simulations of complex traits that incorporate human demography, stabilizing selection, and polygenic adaptation to show how shifts in the fitness landscape generate distinct signals in GWAS summary data. Our test retains power for relatively ancient selection events and controls for potential confounding from linkage disequilibrium. We apply PASTEL to nine complex traits, and find evidence for selection acting on five of them (height, BMI, schizophrenia, Crohn’s disease, and educational attainment). This study provides evidence that selection modulates the relationship between frequency and effect size of trait-altering alleles for a wide range of traits, and provides a flexible framework for future investigations of selection on complex traits using GWAS data.
Diurnal Variations in Excretion of Chloride in Normal Subjects.∗

Summary The day-to-night ratio of urinary chloride excretion has been determined for each of 41 normal subjects and has been calculated for 28 subjects reported in other papers. No restrictions of diet or activity were imposed. In the great majority of the subjects more chloride was excreted /hour during the up-and-about period than during the period of recumbency. This was true regardless of the amount of chloride excreted/24 hours.
Influenza Vaccination of Health Care Workers in Long-Term-Care Hospitals Reduces the Mortality of Elderly Patients

Abstract Vaccination of health care workers (HCWs) is recommended as a strategy for preventing influenza in elderly patients in long-term care. However, there have been no controlled studies to show whether this approach is effective. During the winter of 1994–1995, 1059 patients in 12 geriatric medical long-term-care sites, randomized for vac.cination of HCWs, were studied. In hospitals where HCWs were offered vaccination, 653 (61%) of 1078 were vaccinated. Vaccination of HCWs was associated with reductions in total patient mortality from 17% to 10% (odds ratio [OR], 0.56; 95% confidence interval [CI], 0.40–0.80) and in influenza-like illness (OR, 0.57; 95% CI, 0.34–0.94). Vaccination of patients was not associated with significant effects on mortality (OR, 1.15; 95% CI, 0.81–1.64). Results of this study support recommendations for vaccination against influenza of HCWs in long-term geriatric care. Vaccination of frail elderly long-term-care patients may not give clinically worthwhile benefits.
Testing Extreme Value Copulas to Estimate the Quantile

Testing weather or not data belongs could been generated by a family of extreme value copulas is difficult. We generalize a test and we prove that it can be applied whatever the alternative hypothesis. We also study the effect of using different extreme value copulas in the context of risk estimation. To measure the risk we use a quantile. Our results have motivated by a bivariate sample of losses from a real database of auto insurance claims. Methods are implemented in R.
Ovarian volume and antral follicle count assessed by MRI and transvaginal ultrasonography: a methodological study

Background Ultrasonographic measurements of ovarian volume and antral follicle count are of clinical importance as diagnostic features of polycystic ovarian syndrome (PCOS), and as a parameter in estimation of ovarian follicular reserve in infertility care. Purpose To compare two-dimensional (2D)/three-dimensional (3D) transvaginal ultrasonography (TVUS) and magnetic resonance imaging (MRI) for estimation of ovarian volume and antral follicle count, and to assess reproducibility and inter-observer agreement of MRI measurements. Material and Methods Volumes of 172 ovaries in 99 women aged 21–37 years were calculated (length x width x height x 0.523) with conventional 2D TVUS and 2D MRI. Semi-automatic estimates of ovarian volumes were obtained by 3D MRI. Antral follicles were counted manually on 2D MRI and automatically by 3D TVUS (SonoAVC), and stratified according to follicle size. Results Mean ovarian volume assessed by 2D TVUS (13.1 ± 6.4 mL) was larger than assessed by 2D MRI (9.6 ± 4.1) and 3D MRI (11.4 ± 4.5) (P < 0.001). Total follicle count was higher by 2D MRI than by 3D TVUS, mean difference 14.3 ± 16.2 follicles (P < 0.001). In the smallest size interval of 1–3 mm the mean difference was 22.2 ± 17.6 (P < 0.001). Intra- and inter-observer absolute agreement assessment for MRI measurements of ovarian volume and total follicle count showed ICC coefficients >0.77. Conclusion 2D MRI reveals more antral follicles, especially of small size, than 3D TVUS. Ovarian volume estimation by MRI provides smaller volumes than by the reference standard 2D TVUS. Ovarian volume estimation by 3D MRI, allowing independence of non-ellipsoid ovarian shape measurement errors, provides volumes closer to 2D TVUS values than does 2D MRI. Reproducibility and inter-observer agreement of 2D MRI measurements of ovarian volume and total follicle count are good.
Regulation of type 1 angiotensin II receptor and its subtype gene expression in kidney by sodium loading and angiotensin II infusion

Objective To test the hypothesis that a high salt intake decreases gene expression of both type 1 angiotensin receptor subtypes 1A and 1B (AT1A and AT1B) and diminishes AT1 receptor density in the kidney through an angiotensin II (Ang II)-independent mechanism. Methods Wistar rats were divided into four groups and fed a normal-sodium diet (0.5%, NSD), NSD + 25 ng/kg per min Ang II infusion, a high-sodium diet (4%, HSD), or HSD + Ang II infusion for 2 weeks. Quantitative reverse transcriptase—polymerase chain reaction was used for analysis of changes in renal AT1A and AT1B messenger RNA (mRNA) levels. Radioligand binding assays were used for measurement of Ang II receptor density. Results Body weight and mean arterial pressure did not differ among the four groups. Renal AT1A and AT1B mRNA levels were decreased significantly in NSD + Ang II and HSD + Ang II groups compared with those in the NSD group. Renal AT1B mRNA was also decreased significantly in HSD versus NSD. The renal AT1 receptor density was decreased significantly in NSD + Ang II and HSD + Ang II, but was not changed in HSD compared with NSD. Conclusion A high salt intake downregulates the AT1B mRNA expression but does not change the AT1A mRNA expression and AT1 receptor density in the kidney, suggesting that differential regulation occurs in the kidney. Infusion of a nonpressor dose of Ang II, either alone or in conjunction with a high salt intake, downregulates the AT1 receptor and its subtype gene expression in the kidney, suggesting that Ang II regulates these responses through a negative feedback mechanism.
Clinical experience using 5% hypertonic saline as a safe alternative fluid for use in trauma.

BACKGROUND Published experience of hypertonic saline (HTS) use in resuscitation has described the use of commercially unavailable 7.5% solutions. The purpose of this study was to compare our experience with the administration of commercially available 5% HTS solution with that of well-matched controls who did not receive HTS. METHODS Prospective observational study of 51 trauma patients receiving 500 mL of 5% HTS during initial resuscitation. Patients who received HTS were 1:2 matched using age, gender, Injury Severity Score, Coma Score, Head Abbreviated Injury Scale, and injury mechanism to trauma patients who did not receive HTS. The laboratory values and outcomes of the two groups were compared. RESULTS Patients receiving HTS demonstrated no difference from the matched cohort in mean pH, international normalized ratio, or p/f ratios at 8 hours or 24 hours. The mean serum sodium of the HTS group was higher than controls at 8 hours (143.1 vs. 150.1 mg/dL, p < 0.001) and remained significantly more increased for 3 days without any adverse sequelae related to hypernatremia. No difference in mortality was noted between the two groups. A trend in decreased mortality was observed in patients with Coma Score <or=8 and Head Abbreviated Injury Scale score >or=3 (25.0% vs. 42.5%). The mean ventilator days were 7.3 for HTS group and 9.2 for the non-HTS group. CONCLUSION Although serum sodium remained increased for several days after HTS administration, no adverse sequelae as a result of hypernatremia resulted. Commercially available 5% HTS solution is safe for use in the resuscitation of trauma patients and may improve outcomes in a selected subset of patients with head injury.
Dynamic Capabilities, Human Resources and Operating Routines: A New Product Development Approach

Purpose – The purpose of this paper is to explain the outcomes and role of dynamic capabilities (DCs). To explain the outcomes, the authors study the relationship between new product development (NPD) (an example of DCs) and metaflexibility. To explain the role of DCs, the authors study how human resources and operating routines moderate the role of DCs in achieving adaptation in the firm. Design/methodology/approach – Using data from 200 managers of Spanish firms, the authors apply regression analysis to test the moderating role of human resources and operating routines in the relationship between NPD and metaflexibility. Findings – The results demonstrate that highly qualified and committed workers enhance the effectiveness of NPD, while high frequency in repetition of operating routines significantly damages such effectiveness. Research limitations/implications – This study is limited to analysing a unique DC (NPD), but future research could explore contributions on other consolidated DCs (e.g. allianc.
Blind Watermarking using QIM and the Quantized SVD Domain based on the q-Logarithm Function

We propose new image blind watermarking by using both the quantization index modulation (QIM) technique and the quantized singular value decomposition (SVD) domain based on the q-logarithm function. In order to reduce the distortion of the embedded image, we employ the q-logarithm transform on the Y component of the original image after performing the SVD domain. We call this domain the q-SVD domain. In our proposed method, the tradeoff of robustness and quality can be controlled by a predefined quantization coefficient Q of QIM and a parameter q of the q-SVD domain. Several experiments are conducted to show the robustness of our proposed method against processing attacks and geometric attacks.
Increased arterial stiffness in nonobese women with polycystic ovary syndrome (PCOS) without comorbidities: one more characteristic inherent to the syndrome?

Background Polycystic ovary syndrome (PCOS) is associated with adverse metabolic effects. Some cardiovascular disease (CVD) risk markers are increased in women with PCOS. However, early markers of atherosclerosis are also associated with obesity and insulin resistance, which are related to PCOS. These markers may result either directly from PCOS or indirectly as a consequence of the comorbidities associated with the syndrome.
Isopranoid- and dipalmitoyl-aminophospholipid adjuvants impact differently on longevity of CTL immune responses

The success of lipid membranes as cytotoxic T-cell (CTL) adjuvants requires targeted uptake by antigen-presenting cells (APCs) and delivery of the antigen cargo to the cytosol for processing. To target the phosphatidylserine (PS) receptor of APCs, we prepared antigen-loaded liposomes containing dipalmitoylphosphatidylserine and archaeal lipid liposomes (archaeosomes), containing an equivalent amount of archaetidylserine, and compared their ability to promote short and long-term CTL activity in animals. CTL responses were enhanced by the incorporation of PS into phosphatidylcholine/cholesterol liposomes and, to a lesser extent, into phosphatidylglycerol/cholesterol liposomes, that correlated to the amount of surface amino groups reactive with trinitrobenzoyl sulfonate. Archaeosomes contrasted to the liposome adjuvants by exhibiting higher amounts of surface amino groups and inducing superior shorter and, especially, longer-term CTL responses. The incorporation of dipalmitoyl lipids into archaeosomes induced instability and prevented long-term, but not short-term, CTL responses in mice. The importance of glycero-lipid cores (isopranoid versus dipalmitoyl) to the longevity of the CTL response achieved was shown further by incorporating dipalmitoyl phosphatidylethanolamine (DPPE) or equivalent amounts of synthetic archaetidylethanolamine (AE) into archaeosome adjuvants. Both DPPE and AE at equivalent (5 mol%) concentrations enhanced the rapidity of CTL responses in mice, indicating the importance of the head group in the short term. In the longer term, 5% of DPPE (but not 5% of AE) was detrimental. In addition to head-group effects critical to the potency of short-term CTL responses, the longer term CTL adjuvant properties of archaeosomes may be ascribed to stability imparted by the archaeal isopranoid core lipids.
EXPLORING THE LANGUAGE OF POEMS : A STYLISTIC STUDY

Perceiving the meaning of literary texts requisites studying and understanding the language of these texts. Stylistic approach to literary texts does not only involve linguistic textual analysis but also encourages readers to interact with textual structure to infer meaning (Tutaş, 2006a). This paper focuses on the relevance of stylistics approach for the analysis of poems in Teaching English as a Foreign Language contexts. To this end, Siegfried Sassoon`s The Rear-Guard and Wilfred Owen`s Anthem for Doomed Youth are taken into consideration. After having explained in what ways stylistic analysis helps the reader to come to terms with the process of coding the meaning embedded in the text by focusing on the linguistic features, the two poems are compared and contrasted via a stylistic approach. The paper does not solely focus on analysing the texts, but also argues in favour of exploiting language-based approaches in literature study in English as a Foreign Language contexts, since stylistics is interested in what writers do with and through language.
Acute coronary syndrome: potassium, magnesium and cardiac arrhythmia.

BACKGROUND Cardiac arrhythmia is often present in patients with acute coronary syndrome (ACS) and may be due to the electrolyte imbalance. AIM To assess the prevalence and clinical significance of electrolyte imbalance in ACS. METHODS Serum potassium and magnesium levels were measured within the first few hours in 204 consecutive patients with ACS admitted to our department over a period of 23 months. Cardiac arrhythmia was documented using continuous ECG monitoring, telemetry or standard ECG. RESULTS Hypokalemia was observed in 34% of patients, and was significantly associated with the occurrence of life-threatening ventricular arrhythmias (26% of patients with potassium level <4 mmol/l vs 11.9% of patients with normokalemia, p<0.001). No relationship was found between potassium level and supraventricular arrhythmias or in-hospital mortality. Decreased magnesium serum concentration was found in 22% of patients but was not significantly associated with cardiac arrhythmias or mortality. CONCLUSIONS Hypokalemia and hypomagnesemia are often present in patients with ACS. The former is associated with dangerous ventricular arrhythmias. Early assessment of electrolyte serum concentration is needed in order to implement proper supplementation.
Size and Organizational Effectiveness: Maintaining a Balance

The paper reviews literature on the effect of size on organizational effectiveness. The paper concludes that the success of organizations to a very large extent depends on their ability to right size and combine the benefits of small and big companies. The paper therefore recommends that Organizations should have a â€œbig company/small company hybridâ€ that combines a large corporationâ€Ÿs resources and reach with a small companyâ€Ÿs simplicity and flexibility. Size should be managed effectively to empower workers and improve the competitiveness of organizations.
Examining the effectiveness of phishing filters against DNS based phishing attacks

– This paper aims to report on research that tests the effectiveness of anti-phishing tools in detecting phishing attacks by conducting some real-time experiments using freshly hosted phishing sites. Almost all modern-day Web browsers and antivirus programs provide security indicators to mitigate the widespread problem of phishing on the Internet. , – The current work examines and evaluates the effectiveness of five popular Web browsers, two third-party phishing toolbar add-ons and seven popular antivirus programs in terms of their capability to detect locally hosted spoofed websites. The same tools have also been tested against fresh phishing sites hosted on Internet. , – The experiments yielded alarming results. Although the success rate against live phishing sites was encouraging, only 3 of the 14 tools tested could successfully detect a single spoofed website hosted locally. , – This work proposes the inclusion of domain name system server authentication and verification of name servers for a visiting website for all future anti-phishing toolbars. It also proposes that a Web browser should maintain a white list of websites that engage in online monetary transactions so that when a user requires to access any of these, the default protocol should always be HTTPS (Hypertext Transfer Protocol Secure), without which a Web browser should prevent the page from loading.
Nicotinamide Mononucleotide Adenylyltransferase Is a Stress Response Protein Regulated by the Heat Shock Factor/Hypoxia-inducible Factor 1α Pathway*

Stress responses are cellular processes essential for maintenance of cellular integrity and defense against environmental and intracellular insults. Neurodegenerative conditions are linked with inadequate stress responses. Several stress-responsive genes encoding neuroprotective proteins have been identified, and among them, the heat shock proteins comprise an important group of molecular chaperones that have neuroprotective functions. However, evidence for other critical stress-responsive genes is lacking. Recent studies on the NAD synthesis enzyme nicotinamide mononucleotide adenylyltransferase (NMNAT) have uncovered a novel neuronal maintenance and protective function against activity-, injury-, or misfolded protein-induced degeneration in Drosophila and in mammalian neurons. Here, we show that NMNAT is also a novel stress response protein required for thermotolerance and mitigation of oxidative stress-induced shortened lifespan. NMNAT is transcriptionally regulated during various stress conditions including heat shock and hypoxia through heat shock factor (HSF) and hypoxia-inducible factor 1α in vivo. HSF binds to nmnat promoter and induces NMNAT expression under heat shock. In contrast, under hypoxia, HIF1α up-regulates NMNAT indirectly through the induction of HSF. Our studies provide an in vivo mechanism for transcriptional regulation of NMNAT under stress and establish an essential role for this neuroprotective factor in cellular stress response.
Measurement Characteristics of the Pediatric Asthma Health Outcome Measure

Introduction. The Pediatric Asthma Health Outcome Measure (PAHOM) was designed to measure quality-adjusted life years (QALYs) in children with asthma. Our objective was to compare parent- and child-reported PAHOM scores to each other, to parent-reported scores on the Juniper Asthma Control Questionnaire (ACQ), and to physician-rated asthma control. Methods. A convenience sample of primarily African-American parent–child dyads (N = 261) was recruited from asthma clinics between May 2008 and May 2010. Correlations and differences in scores between the instruments and respondents were compared across variables of interest. The sensitivity and specificity of each, relative to physician-rated asthma control, were estimated. Results. Mean (SD) parent- and child-reported PAHOM scores were significantly different, 0.91 (0.13) and 0.95 (0.08), respectively, (p < .01) and were weakly correlated (0.24). Parent-reported PAHOM and parent-reported ACQ, 5-item version (ACQ5) scores were moderately correlated (−0.69). Both the parent- and child-reported PAHOM scores distinguished between physician-rated well-controlled and not well-controlled asthma (p < .01 and p < .01, respectively). When compared with physician-rated asthma control, the areas under the receiver operating characteristic (ROC) curves for the parent-reported PAHOM and the ACQ5 were similar (p = .11), but both performed better than the child-reported PAHOM (both p < .01). Discussion. The validity of the PAHOM is supported by its moderate correlation with the ACQ and its association with physician-rated asthma control. Although intended to be administered to children, parent-reported scores were better predictors of physician-rated asthma control. Conclusions. A validation study in a more economically and ethnically diverse population is needed. Until then, we recommend the PAHOM to be administered to both parents and children.