Miracle-dz/UniFAR-FTUs huggingface dataset:
Inhibition of Glutamate Release by Arachidonic Acid in Rat Cerebrocortical Synaptosomes

The action of arachidonic acid on glutamate release in rat cerebrocortical synaptosomes was investigated. The Ca2+‐dependent release of glutamate evoked by 4‐aminopyridine (4‐AP) was inhibited by arachidonic acid (0.5–10 μM), but the KC1‐evoked release was not modified. The Ca2+‐independent release of glutamate was insensitive to low concentrations of arachidonic acid, but higher concentrations of this free fatty acid (30 μM) induced a slow efflux of cytoplasmic glutamate. The decrease in the Ca2+‐dependent release of glutamate by arachidonic acid was consistent with a reduction in both the depolarization and the subsequent rise in the cytoplasmic free Ca2+ concentration induced by 4‐AP in the nerve terminal. The inhibitory action by arachidonic acid observed in glutamate release was reversed in the presence of the K+‐channel Mocker tetraethyl‐ammonium.
The Schizosaccharomyces pombe mam2 gene encodes a putative pheromone receptor which has a significant homology with the Saccharomyces cerevisiae Ste2 protein.

The fission yeast Schizosaccharomyces pombe has two mating‐types, h+ (P) and h‐ (M). The mam2 mutant exhibits an h(−)‐specific sterile phenotype. Nucleotide sequencing of the mam2 gene isolated from an S. pombe genomic library revealed an open reading frame composed of 348 amino acids. The deduced mam2 product is a hydrophobic protein of 39 kDa that has significant sequence similarity (26.3% for identical amino acids) with the transmembrane domains of the Saccharomyces cerevisiae STE2 product, the alpha‐pheromone receptor. Hydropathicity analysis suggests that the Mam2 protein contains seven possible membrane‐spanning domains and a carboxy‐terminal hydrophilic region. The mam2 gene was disrupted and found to be non‐essential for growth. An h‐ haploid strain harbouring this disrupted null allele failed to respond to the pheromone of h+ cells, P‐factor. These observations imply that the mam2 gene encodes a receptor for P‐factor. Transcription of mam2 was induced only when strains containing functional mat1‐M allele were cultured under conditions of nitrogen starvation. The mam2 gene was also transcribed in h+/h‐ diploid strains. The fact that the map1/mam2 homozygous diploid cells are incapable of sporulation implies that the pheromone signalling system is necessary for sporulation in diploid cells.
Revisiting Sphere Unfolding Relationships for the Stereological Analysis of Segmented Digital Microstructure Images

Sphere unfolding relationships are revisited with a specific focus on the analysis of segmented digital images of microstructures. Since the features of such images are most easily quantified by counting pixels, the required equations are re-derived in terms of the histogram of areas (instead of diameters or radii) as inputs and it is shown that a substitution can be made that simplifies the calculation. A practical method is presented for utilizing negative number fraction bins (which sometimes arise from erroneous assumptions and/or insufficient numbers of observations) for the creation of error bars. The complete algorithm can be implemented in a spreadsheet. The derived unfolding equations are explored using both linear and logarithmic binning schemes, and the pros and cons of both binning schemes are illustrated using simulated data. The effects of the binning schemes on the stereological results are demonstrated and discussed with reference to their consequences for practical materials characterization situations, allowing for the suggestion of guidelines for proper application of this, and other, distribution-free stereological methods.
The Bhopalator: An Information/Energy Dual Model of the Living Cell (II)

A molecular model of the living cell known as the Bhopalator is described with the hope of aiding mathematicians and computer scientists to develop comprehensive algebraic models of the cell. The Bhopalator is energy/information dual in the sense that it can be described using two complementary languages - the energy/matter based language of physics and chemistry and the information/sign based language of linguistics and mathematics. The availability of mathematical models of the cell may eventually lead to developing computer models of the living cell, resulting in important applications not only in biology and medicine but also in computer science and computer industry. To stimulate discussions among mathematicians and computer scientists, the algebraic encoding of the essential characteristics of the Bhopalator may be referred to as the C system (C indicating the cell), in analogy to the well-known H and P systems.
A New Satellite-Based Indicator for Estimation of the Western North Pacific Tropical Cyclone Current Intensity

A technique to estimate tropical cyclone (TC) current intensity based on geostationary satellite infrared window (IRW) and water vapor (WV) imagery is explored in this paper. First, to combine the advantages of the IRW imagery and the WV minus IRW (WV-IRW) imagery, a WV-IRW-to-IRW ratio (WIRa)-based indicator is proposed. This indicator not only can display the inner-core convection's symmetrization level and vigor but also is able to screen out thin cirrus, stratospheric WV anomaly, and overshooting tops from average deep convection. It is highly correlated with the best track minimum sea-level pressure and thus used to estimate the western North Pacific TC current intensity. Detailed analyses have demonstrated that the WIRa-based indicator can further improve the estimation of TC current intensity alongside the existing algorithms. The WIRa-based indicator is designed based on the hypothesis that “overshooting top is more useful for forecasting than initial estimation,” and the satisfying results of the WIRa-based method perhaps provide indirect evidence to support this hypothesis in turn.
Business Diplomacy: The elucidation to ease multinational corporation’s business risk in developing countries and conflict-prone zones

These days, multinational corporations are no longer ‘innocent’ business actors but play an important role in international relations as well. Entering markets and opening operations in developing countries or conflict-related regions is attractive for MNCs since the margins are high and the potential for growth extensive. However, operating in developing countries and especially conflict-related regions is also risky. Recent research described what kind of diplomatic actions were already accomplished by principled leaders to manage in conflict-related regions. The topic needs far more research to better understand how MNCs act in conflict-related regions to succeed. Therefore, this study investigated on an explorative basis to answer the question: “How do principled leaders manage their company’s business successfully by conducting business diplomacy in developing countries and conflict-prone zones? ”. Grounded theory was used for the methodology and interviews were conducted with nine principled leaders from different MNCs that operated in diverse sectors. Results showed that business diplomacy was conducted by every MNC but to different degrees to minimize business’ risks and maximize business’ opportunities. Based on that, a Business Diplomacy Framework Matrix was developed laying a theoretical foundation for understanding how MNCs can act when launching a new venture in a conflict-related region.
Do measures of externalising behaviour in normal populations predict later outcome?: Implications for targeted interventions to prevent conduct disorder.

Mental health professionals involved with the care of children and adolescents are frequently confronted with questions about the risk of later troublesome outcomes. Of particular concern is whether the presence of certain risk factors warrants the provision of an intervention. The presence of externalising behaviour symptoms is regarded by many as the single best predictor of risk for future conduct disorder and antisocial behaviour (Loeber, 1991; Lynam, 1996; Moffitt, 1993; Patterson, 1993; Yoshikawa, 1994). These symptoms include aggression against others, destruction of the personal property of others, temper tantrums, and noncompliance, to name but a few. The evidence suggests that when these behaviours are present in childhood there is an increased risk for persistent, life-long psychosocial problems (Loeber, 1982; Loeber & Dishion, 1983; Moffitt, 1993; Olweus, 1979; Yoshikawa, 1994). For example, a link between the early onset of externalising behaviours and the later development of conduct disorder, antisocial behaviour, and substance abuse has been documented in both longitudinal and retrospective studies (Caspi, Moffitt, Newman, & Silva, 1996; Farrington, 1990; Robins, 1978; Tremblay, Pihl, Vitaro, & Dobkin, 1994; White, Moffitt, Earls, Robins, & Silva, 1990; Zoccolillo, Tremblay, & Vitaro, 1996). The risks associated with externalising symptoms and the relatively modest effectiveness of treatment for established cases of conduct disorder and antisocial behaviour (Kazdin, 1997; Offord, 1989; Offord & Bennett, 1994) have led to an increased emphasis on the provision of preventive interventions (Institute of Medicine, 1994; Reiss & Price, 1996). It has been argued that intervention should be provided to high-risk children as early as possible. Claims have been made that even in nonclinic populations of children as young as 4 and 5 years of age, 50% or more of those with troublesome externalising symptoms will develop persistent psychosocial problems (Campbell, 1995; Coie, 1996; Reid, 1993; Reid & Patterson, 1991).
Are financially constrained firms susceptible to a stock price crash?

This study investigates whether and how financial constraints on firms affect the risk of their stock price crashing. We find strong evidence that financial constraints increase future stock price crash risk. This finding is robust to using two quasi-natural experiments to control for potential endogeneity. We also provide evidence to suggest that bad news hoarding and default risk explain the crash risk of financially constrained firms. Cross-sectional analysis reveals that the positive relation between financial constraints and future crash risk is more prominent for firms with weak corporate governance. Our study is of interest to investors as well as other stakeholders concerned about firms’ creditworthiness and viability.
Slip Interface Imaging Predicts Tumor-Brain Adhesion in Vestibular Schwannomas.

PURPOSE To test the clinical feasibility and usefulness of slip interface imaging (SII) to identify and quantify the degree of tumor-brain adhesion in patients with vestibular schwannomas. MATERIALS AND METHOD S With institutional review board approval and after obtaining written informed consent, SII examinations were performed in nine patients with vestibular schwannomas. During the SII acquisition, a low-amplitude mechanical vibration is applied to the head with a pillow-like device placed in the head coil and the resulting shear waves are imaged by using a phase-contrast pulse sequence with motion-encoding gradients synchronized with the applied vibration. Imaging was performed with a 3-T magnetic resonance (MR) system in less than 7 minutes. The acquired shear motion data were processed with two different algorithms (shear line analysis and calculation of octahedral shear strain [OSS]) to identify the degree of tumor-brain adhesion. Blinded to the SII results, neurosurgeons qualitatively assessed tumor adhesion at the time of tumor resection. Standard T2-weighted, fast imaging employing steady-state acquisition (FIESTA), and T2-weighted fluid-attenuated inversion recovery (FLAIR) imaging were reviewed to identify the presence of cerebral spinal fluid (CSF) clefts around the tumors. The performance of the use of the CSF cleft and SII to predict the degree of tumor adhesion was evaluated by using the κ coefficient and McNemar test. RESULTS Among the nine patients, SII agreed with the intraoperative assessment of the degree of tumor adhesion in eight patients (88.9%; 95% confidence interval [CI]: 57%, 98%), with four of four, three of three, and one of two cases correctly predicted as no adhesion, partial adhesion, and complete adhesion, respectively. However, the T2-weighted, FIESTA, and T2-weighted FLAIR images that used the CSF cleft sign to predict adhesion agreed with surgical findings in only four cases (44.4% [four of nine]; 95% CI: 19%, 73%). The κ coefficients indicate good agreement (0.82 [95% CI: 0.5, 1]) for the SII prediction versus surgical findings, but only fair agreement (0.21 [95% CI: -0.21, 0.63]) between the CSF cleft prediction and surgical findings. However, the difference between the SII prediction and the CSF cleft prediction was not significant (P = .103; McNemar test), likely because of the small sample size in this study. CONCLUSION SII can be used to predict the degree of tumor-brain adhesion of vestibular schwannomas and may provide a method to improve preoperative planning and determination of surgical risk in these patients.
Evidence transfer: ensuring end users are aware of, have access to, and understand the evidence

ABSTRACT The Joanna Briggs Institute Model of evidence-based healthcare (EBHC) states that the main phases of EBHC include evidence synthesis, transfer, and implementation. There has been some confusion regarding the term ‘evidence transfer’, with this term previously being considered by many as synonymous with knowledge or evidence translation. The aim of this paper is to discuss a proposed definition of evidence transfer and the pivotal role it plays as part of the EBHC process. ‘Evidence transfer’ can be thought of simply as getting the message (evidence) across and at its core it is all about information delivery. We specifically define evidence transfer as a process that helps communicate or convey the results of research or evidence, or brings evidence to the forefront. It is focused on ensuring people are aware of, have access to and understand evidence.
Do Technology Spillovers Accelerate Performance of Firms? Unravelling a Puzzle from Indian Manufacturing Industry

This paper explores the relationship between technology spillovers and productivity for a sample of Indian manufacturing firms over the period 2001-2012. Technology spillovers are defined as function of technology adoption (R&D and technical know-how) and technology diffusion (imports and exports). The paper considers two measures of productivity, namely total factor productivity (TFP) and labor productivity for analysis. For TFP, Results show that firms that are engaged in technology adoption found to be more productive than other. For labor productivity, results demonstrate that firms that are engaged in technology adoption and technology diffusion through imports appear to be more productive than others. This validates the fact that Indian manufacturing firms represent learning-by-importing phenomenon due to their general labor-intensive production processes. The results represent a weak link between technology diffusion through exports and TFP, however strong links are established among labor productivity, technology diffusion through imports & R&D.
Multiple Temporal Cluster Detection

Summary. This article proposes a simple method to determine single or multiple temporal clustering on a variable size population. By a transformation of the data set, the method based on a regression model allows consideration of a variable population size during the time of study. A model selection procedure and a resampling method are used to select the number of clusters. The results have applications in epidemiological studies of rare diseases.
Knowledge quality: Antecedents and consequence in project teams

Purpose – The purpose of this study is to address the nature of knowledge quality, describe its dimensions, and create valid and reliable instruments to measure it. Knowledge quality is proposed as a second‐order factor model which includes three dimensions: intrinsic knowledge quality, contextual knowledge quality, and actionable knowledge quality. This study also aims to examine important antecedents to and an outcome of knowledge quality.Design/methodology/approach – Data collected from 208 project teams were used to test measures of knowledge quality and to examine a proposed research framework by using LISREL for structural equation modeling.Findings – Results support the claim that knowledge quality has three dimensions. The results also show that functional diversity, absorptive capacity, and knowledge networks are critical antecedents that positively impact knowledge quality, which in turn has an influence on innovation.Research limitations/implications – The research framework enables academician.
Is “proof” the Eighth “P” of Service? A Conceptual Model and Propositions

ABSTRACT The article aims at making a conceptual contribution to services marketing literature by proposing an eighth “P” called “proof. ” Proof is a simple operational measure or an intuitive indicator that helps the customer quickly assess the efficacy of a service. The article discusses services marketing literature and develops propositions that underscore the importance of proof as the eighth P. When proof is provided about a service to the customer, it affects all service outcomes (i.e., service evaluation, purchase intent, customer satisfaction, and repurchase intent). Though conceptual, the article provides practical implications as well.
Group Exercise versus Personal Training for Prostate Cancer Patients: A Pilot Randomized Trial

Background: Previous studies have demonstrated psychosocial and physical benefit from exercise for older men treated with androgen deprivation therapy (ADT) for prostate cancer (PCa). To date, different intervention delivery methods have not been assessed. This study compared the effect of group-based exercise (GBE) to personal training (PT) in men undergoing ADT for PCa. Methods: 13 participants (mean age = 68.2, SD = 7.2) were randomly assigned to GBE or PT for 8 weeks. Participants exercised for 60 minutes three times per week at a moderate-vigorous intensity. Results: 10 participants completed the intervention. At post-intervention, the PT group improved: fatigue, systolic BP, waist circumference, body fat percentage, and maximal leg strength; participants in the GBE group improved leg strength. At 8 weeks, maximal upper body strength in the PT group was greater than the GBE group. There were no adverse events associated with moderate-high intensity training in this population of older men. Conclusion: PT may be more efficacious than GBE in improving several physical fitness outcomes and fatigue in men with PCa who are androgen deprived. Due to the small sample size and attrition, these results require cautious interpretation and confirmation from adequately powered trials.
Memory for drug-related visual stimuli in young adult, cocaine-dependent polydrug users

Abstract Background and objectives: Implicit (unconscious) and explicit (conscious) memory associations with drugs have been examined primarily using verbal cues. However, drug seeking, drug use behaviors, and relapse in chronic cocaine and other drug users are frequently triggered by viewing substance-related visual cues in the environment. We thus examined implicit and explicit memory for drug picture cues to understand the relative extent to which conscious and unconscious memory facilitation of visual drug cues occurs during cocaine dependence. Methods: Memory for drug-related and neutral picture cues was assessed in 14 inpatient cocaine-dependent polydrug users and a comparison group of 21 young adults with limited drug experience (n = 35). Participants completed picture cue exposure, free recall and recognition tasks to assess explicit memory, and a repetition priming task to assess implicit memory. Results: Drug cues, compared to neutral cues, were better explicitly recalled and implicitly primed, and especially so in the cocaine group. In contrast, neutral cues were better explicitly recognized, and especially in the control group. Conclusion: Certain forms of explicit and implicit memory for drug cues were enhanced in cocaine users compared to controls when memory was tested a short time following cue exposure. Enhanced unconscious memory processing of drug cues in chronic cocaine users may be a behavioral manifestation of heightened drug cue salience that supports drug seeking and taking. There may be value in expanding intervention techniques to utilize cocaine users’ implicit memory system.
Lupus-like disease and high interferon levels corresponding to trisomy of the type I interferon cluster on chromosome 9p.

OBJECTIVE Systemic lupus erythematosus (SLE) is associated with type I interferons (IFNs) and can be induced by IFNalpha treatment. This study looked for evidence of autoimmunity in a pedigree consisting of 4 family members with a balanced translocation 9;21 and 2 members with an unbalanced translocation resulting in trisomy of the short (p) arm and part of the long (q) arm of chromosome 9. These latter 2 subjects had 3 copies of the IFN gene cluster. METHODS Subjects were evaluated clinically and serologically for autoimmune disease. Expression levels of IFNalpha4, IFNbeta, the type I IFN-inducible gene Mx1, the type I IFN receptor, interleukin-6, and tumor necrosis factor alpha were determined by real-time polymerase chain reaction. Circulating plasmacytoid dendritic cells, the main IFN-producing cells, were quantified by flow cytometry. RESULTS Both subjects with trisomy of chromosome 9p had a lupus-like syndrome with joint manifestations and antinuclear antibodies: one had anti-RNP and antiphospholipid autoantibodies, and the other had anti-Ro 60. The 3 family members with a balanced translocation 9;21 had no clinical or serologic evidence of autoimmunity, similar to that in relatives who were unaffected by the chromosomal translocation. In the 2 subjects with trisomy of 9p, high levels of IFNalpha/beta (comparable with those found in patients with SLE), increased signaling through the IFN receptor (as indicated by high Mx1 expression), and low levels of circulating plasmacytoid dendritic cells (as observed in patients with SLE) were evident. These abnormalities were not seen in individuals with a balanced translocation. CONCLUSION Trisomy of the type I IFN cluster of chromosome 9p was associated with lupus-like autoimmunity and increased IFNalpha/beta and IFN receptor signaling. The data support the idea that abnormal regulation of type I IFN production is involved in the pathogenesis of SLE.
PENGARUH KUALITAS PRODUK DAN PROMOSI TERHADAP KEPUTUSAN PEMBELIAN (Studi pada Pembeli dan Pengguna Honda Beat Series di Astra Honda Motor Gajahmada Semarang)

products with various advantages. One of the automotive products that often discussed is honda beat series. To face up fierce business competition honda beat series needs to influence consumers to choose and buy products honda beat series. Many factors affect consumers in making purchases, including Product Quality and Promotion. This study aims to determine the quality of products and promotion for product purchase decision of honda beat series partially and simultaneously. This type of research is explanatory research. The questionnaire primary data is used and distributed to Semarang people who decided to buy and use honda beat series at astra honda motor gajahmada semarang dealer, counted as many as 100 people. In the analysis used validity and reliability, correlation coefficient, coefficient of determination, simple and multiple regression analysis, and significance test (t test and F test) using SPSS 22. The result of this study showed that the contribution given by product's quality (X1) toward buying decision (Y) is 9.6%. The contribution given by promotion (X2) toward buying decision (Y) is 23.9%. The contribution given by product's quality (X1) and promotion (X2) toward buying decision (Y) is 24.1%. From the two variables that affect buying decision, promotion is the most significant variable that affects the customer's decision to buy Honda Beat Series.