Miracle-dz/UniFAR-FTUs huggingface dataset:
Security Issues and Recommendations for Online Social Networks.

ENISA position papers represent expert opinion on topics ENISA considers to be important emerging risks. They are produced by a group selected for their expertise in the area. The content was collected via wiki, mailing list and telephone conferences, edited by ENISA and the final version has been reviewed by the people listed below. This paper aims to provide a useful introduction to security issues in the area of Social Networking, highlight the most important threats and make recommendations for action and best practices to reduce the security risks to users. Examples are given from a number of providers throughout the paper. These should be taken as examples only and there is no intention to single out a specific provider for criticism or praise. The examples provided are not necessarily those most representative or important, nor is the aim of this paper to conduct any kind of market survey, as there might be other providers which are not mentioned here and nonetheless are equally or more representative of the market. Audience This paper is aimed at corporate and political decision-makers as well as Social Network application-providers. It also seeks to raise awareness among political and corporate decision-makers of the legal and social implications of new developments in Social Networking technologies. In particular, the findings should have important implications for education and data protection policy. Group members participate as individuals. This paper should therefore not be taken as representing the views of any company or other organisation, and does not in any way bind group members when dealing with the issues it covers in other contexts.
A 20-50 GHz RF MEMS single-stub impedance tuner

A novel radio-frequency (RF) microelectromechanical system (MEMS) single-stub impedance tuner has been developed. The design is based on combining the loaded line technique with the single-stub topology to obtain wide impedance coverage with high |/spl Gamma//sub MAX/|. The tuner consist of ten switched MEMS capacitors producing 1024(2/sup 10/) different impedances. The design has been optimized for noise parameter and load-pull measurements of active devices and shows excellent measured impedance coverage over the 20-50 GHz frequency range.
Multiple pollutant discharge permit markets, a challenge for wastewater treatment plants

This study focuses on the challenge of using a multiple pollutant transferable discharge permit market for operating wastewater treatment plants. It uses an analytical case of Sefidrud River in Iran with two checkpoints. It shows that the operating limitations for simultaneous biochemical oxidation demand (BOD) and total nitrogen (TN) removal may convert the economically optimal waste load allocation (WLA) to a framework with lack of incentives. Therefore, water quality trading (WQT) may lose its economical advantages. In this case, a third parameter, such as dissolved oxygen is recommended as an index for assigning market interactions. In spite of economical and practical success, this approach made WLA become a more complicated and uncertain policy. It was totally concluded that using single parameter WQT is only recommended for areas with small agricultural activities or lakes. Otherwise, the integrated discharged permit and reclaimed water market is proposed instead for simultaneous BOD and TN management.
Upward trends of acquired drug resistances in Ethiopian HIV-1C isolates: A decade longitudinal study

Background The emergence, accumulation and spread of HIV-1 drug resistance strains in Africa could compromise the effectiveness of HIV treatment programs. This study was aimed at determining the incidence of virological failure and acquired drug resistance mutations overtime and identifying the most common mutational pathways of resistance in a well characterized HIV-1C infected Ethiopian cohort. Methods A total of 320 patients (220 ART naïve and 100 on first lines ART) were included and followed. ART initiation and patients’ monitoring was based on the WHO clinical and immunological parameters. HIV viral load measurement and genotypic drug resistance testing were done at baseline (T0-2008) and after on average at a median time of 30 months on ART at three time points (T1-2011, T2-2013, T3-2015). Findings The incidence of virological failure has increased overtime from 11 at T1 to 17 at T2 and then to 30% at T3. At all time point’s almost all of the patients with virological failure and accumulated drug resistance mutations had not met the WHO clinical and immunologic failure criteria and continued the failing regimen. A steep increase in the incidence and accumulation of major acquired NRTI and NNRTI drug resistance mutations have been observed (from 40% at T1 to 64% at T2 and then to 66% at T3). The most frequent NRTIs drug resistance associated mutations are mainly the lamivudine-induced mutation M184V which was detected in 4 patients at T1 and showed a 2 fold increase in the following time points (T2: n = 8) and at (T3: n = 12) and the thymidine analogue mutations (such as D67N, K70R and K219E) which were not-detected at baseline T0 and T1 but were increased progressively to 10 at T2 and to 17 at T3. The most frequent NNRTIs associated mutations were K103N, V106M and Y188C. Conclusions An upward trend in the incidence of virological failure and accumulation of NRTI and NNRTI associated acquired antiretroviral drug resistance mutations are observed. The data suggest the need for virological monitoring, resistance testing for early detection of failure and access for TDF and PI containing drugs. Population-level and patient targeted interventions to prevent the spread of mutant variants is warranted.
Effects of exogenous collagenase and cholesterol esterase on the durability of the resin-dentin bond.

PURPOSE The purpose of this work was to determine microtensile dentin bond strengths (microTBS) of dentin-resin composite bonds after three-month storage in artificial saliva containing either collagenase (COL) or cholesterol esterase (EST). The null hypothesis tested is that the resin-dentin bond strength is equivalent for each storage medium at the tested storage times. MATERIALS AND METHODS Resin composite was bonded to occlusal dentin, and microTBS specimens were formed and stored in the artificial saliva, COL, EST, or synthetic oil. After 24 h and 12-week storage, microTBS was determined and failure modes were characterized by SEM. The interfacial ultrastructure was evaluated by transmission electron microscopy as unstained and stained sections (phosphotungstic acid/uranyl acetate). Statistical analysis was performed by ANOVA and Weibull survival analyses at the 0.05 level of statistical significance. RESULTS There were significantly weaker bond strengths after 12 weeks for all experimental storage media (p < 0.001). Artificial saliva containing EST lowered bond strengths to a significantly greater extent than did COL after 12 weeks of storage, while no difference between these groups could be discerned after 24 h. Therefore, the null hypothesis of this experiment is rejected. CONCLUSION Exogenous enzymatic challenge to resin-dentin bonds decreased bond durability only with EST. However, when further challenges to ideal infiltration of the comonomers into the hybrid layer were carried out using inadequate removal of solvent, additional alterations in hybrid layer ultrastructure were discerned by TEM that may represent different potential degradative processes. The contribution of endogenous enzymatic challenges to the primary degradative process, ie, hydrolysis, is unknown and deserves continued attention.
New Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of Action

Background: Competitors of LEDGF binding to HIV-1 integrase could prevent targeted integration to chromatin. Results: LEDGF competitors like tBPQAs were also found to inhibit integrase enzyme activity by preventing proper integrase-viral DNA assembly. Conclusion: tBPQAs are allosteric inhibitors of integrase with a dual mode of action. Significance: Interference with two distinct steps of integration through the same binding site represents a new antiviral paradigm. tert-Butoxy-(4-phenyl-quinolin-3-yl)-acetic acids (tBPQA) are a new class of HIV-1 integrase (IN) inhibitors that are structurally distinct from IN strand transfer inhibitors but analogous to LEDGINs. LEDGINs are a class of potent antiviral compounds that interacts with the lens epithelium-derived growth factor (LEDGF) binding pocket on IN and were identified through competition binding against LEDGF. LEDGF tethers IN to the host chromatin and enables targeted integration of viral DNA. The prevailing understanding of the antiviral mechanism of LEDGINs is that they inhibit LEDGF binding to IN, which prevents targeted integration of HIV-1. We showed that in addition to the properties already known for LEDGINs, the binding of tBPQAs to the IN dimer interface inhibits IN enzymatic activity in a LEDGF-independent manner. Using the analysis of two long terminal repeat junctions in HIV-infected cells, we showed that the inhibition by tBPQAs occurs at or prior to the viral DNA 3′-processing step. Biochemical studies revealed that this inhibition operates by compound-induced conformational changes in the IN dimer that prevent proper assembly of IN onto viral DNA. For the first time, tBPQAs were demonstrated to be allosteric inhibitors of HIV-1 IN displaying a dual mode of action: inhibition of IN-viral DNA assembly and inhibition of IN-LEDGF interaction.
Fast 3D reconstruction using one-shot spatial structured light

Structured light gains its popularity in 3D reconstruction applications due to its robustness against outliers. In the last few decades, a number of high-accuracy temporally encoded structured light emerged to solve the 3D reconstruction problem. However their applications are mainly limited to scanning stationary objects. When dealing with dynamic scenes and real-time data acquisition, one-shot spatial multiplexed structured light has the speed advantage. In this paper, we propose a fast 3D reconstruction method using one-shot special structured light. It works by projecting a static two-dimensional 8-color De Bruijn spatial grid pattern onto the scene, analyzing the deformation of the observed light pattern with respect to the projected one, and identifying their correspondence. Several local optimization strategies are used to offer a confident solution, including special vote majority for color detection and correction, and De Bruijn-based Hamming distance minimization to improve intersection neighborhood information. The effectiveness of the proposed method is verified through 3D reconstruction of a complicated bust.
Age-related histologic changes in human nasal cartilage.

IMPORTANCE Understanding age-related changes is important when considering cartilage-based implants or grafts during rhinoplasty and nasal reconstructive surgery. OBJECTIVE To characterize the cellular and architectural changes in human nasal cartilage with aging. DESIGN Laboratory study. PARTICIPANTS Nasal septal cartilage was harvested from 50 consecutive patients undergoing septoplasty, rhinoplasty, or septorhinoplasty. INTERVENTION Cartilage specimens were stained with hematoxylin-eosin (H&E) and safranin O for cartilage. MAIN OUTCOME MEASURES A modified Mankin histologic grading scale was used to analyze each cartilage sample for H&E findings and safranin O staining. Higher H&E scores indicated more degenerative changes, while higher safranin O scores indicated reductions in proteoglycan content within the cartilage matrix, representing decreased active chondrocyte activity. Correlation between H&E and safranin O scores and patient age was determined. RESULTS There was positive correlation between safranin O staining scores and age, with higher scores seen with advancing age (P = .01). A linear regression best-fit equation was determined to calculate a potential safranin O staining score for a given age. CONCLUSIONS AND RELEVANCE We have quantitatively determined that advancing age is positively correlated with reductions in cartilage proteoglycan content and active cartilage growth. This finding not only enhances our current understanding of the natural changes that occur in cartilage with aging but may also affect surgical decision making when cartilage grafting is considered during functional, reconstructive, and aesthetic rhinoplasty. LEVEL OF EVIDENCE NR.
Large Excess Reserves in the United States: A View from the Cross-Section of Banks

Bank reserves in the United States increased dramatically at the end of 2008. Subsequent asset purchase programs in 2009 and 2011 more than doubled the quantity of reserves outstanding. We study the cross-sectional distribution of reserves in that period, and the relationship between holdings of reserves and other components of banks’ balance sheets. We find that reserves were widely distributed, increasing the liquidity position of many banks which, at the same time, were far from facing tight capital constraints. Our findings have implications for assessing the importance of large quantities of excess reserves for monetary policy.
Different in vivo tolerogenicity of MHC class I peptides

The efficacy of MHC class I‐derived peptides to induce tolerance was tested in a cardiac transplantation model. Two 25‐mer peptides from the polymorphic region of the DA class I molecule (RT1.Aa) were synthesized by F‐moc chemistry and injected intrathymically or intraperitoneally into LEW (RT1.1) responder animals. Intrathymic treatment of the recipient animals with peptide 1 (residues 56–80) accompanied by intraperitoneal treatment with peptide 4 (residues 96–120) led to indefinite survival of allogeneic DA cardiac allografts (n = 7; >100 days). The tolerogenicity of both peptides differed according to the site of inoculation, as donor‐specific tolerance was only observed after administration of peptide 1 into the thymus and injection of peptide 2 into the abdominal cavity of LEW recipients, but not vice versa. Donor‐specific tolerance was confirmed in vivo by grafting of full‐thickness skin and in vitro by appropriate proliferation and cytotoxicity assays using donor and third‐party rats. Donor‐specific tolerance was associated with up‐regulation of interleukin‐4, transforming growth factor β, and interleukin‐10 gene expression within cardiac allografts, thus suggesting intrathymic clonal deletion and external suppression with expansion of T‐helper 2‐type lymphocytes as the underlying mechanisms of tolerance induction. J. Leukoc. Biol. 65: 16‐27; 1999.
Clinicopathological features of primary cutaneous B-cell lymphomas from an academic regional hospital in central Italy: No evidence of Borrelia burgdorferi association

We reviewed the clinico-pathological features of 73 primary cutaneous B-cell lymphomas (PCBCLs), diagnosed in 10 years in Marche region in central Italy, which included 16 marginal zone lymphomas (MZL), 33 follicle centre lymphomas (FCL) and 24 diffuse large B cell lymphomas (DLBCL). We also investigated the presence of Borrelia burgdorferi in tissues by polymerase chain reaction. Differences in age, sex, location site, response to therapy, disease recurrence and 5-year disease-specific survival were observed among the 3 histological groups. Specific DNA sequences of Borrelia burgdorferi were not detected in any of the 73 cases of PCBCL. We conclude that PCBCLs in Marche region behave according to the literature data and do not seem to be associated with Borrelia burgdorferi. Additional investigations should be performed on other possible etiologies, at least in our geographical area.
Sub-Second Temporal Integration of Vibro-Tactile Stimuli: Intervals between Adjacent, Weak, and Within-Channel Stimuli Are Underestimated

Tactile estimation of sub-second time is essential for correct recognition of sensory inputs and dexterous manipulation of objects. Despite our intuitive understanding that time is robustly estimated in any situation, tactile sub-second time is altered by, for example, body movement, similar to how visual time is modulated by eye movement. The effects of simpler factors, such as stimulus location, intensity, and frequency, have also been reported in temporal tasks in other modalities, but their effects on tactile sub-second interval estimation remain obscure. Here, we were interested in whether a perceived short interval presented by tactile stimuli is altered only by changing stimulus features. The perceived interval between a pair of stimuli presented on the same finger apparently became short relative to that on different fingers; that of a weak-intensity pair relative to that of a pair with stronger intensity was decreased; and that of a pair with the same frequency relative to one with different frequencies was underestimated. These findings can be ascribed to errors in encoding temporal relationships: nearby-space/weak-intensity/similar-frequency stimuli presented within a short time difference are likely to be integrated into a single event and lead to relative time compression.
Endobronchial Ultrasound versus Mediastinoscopy for Mediastinal Nodal Staging of Non–Small-Cell Lung Cancer

Introduction: Correct mediastinal staging is critical for determination of the most appropriate management strategy in patients with non–small-cell lung cancer (NSCLC). The purpose of this study was to compare the diagnostic performance of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) with that of mediastinoscopy in patients with NSCLC. Methods: A prospective trial was conducted in a tertiary referral center in Korea. Patients with histologically proven NSCLC and suspicion for N1, N2, or N3 metastasis were enrolled. Each patient underwent EBUS-TBNA followed by mediastinoscopy. Surgical resection and complete lymph node dissection were conducted in patients for whom no evidence of mediastinal metastasis was apparent after mediastinoscopy. Results: In total, 138 patients underwent EBUS-TBNA and 127 completed both EBUS-TBNA and mediastinoscopy. N2/N3 disease was confirmed in 59.1% of the patients. The diagnostic sensitivity, specificity, accuracy, positive predictive value, and negative predictive value (NPV) of EBUS-TBNA on a per-person analysis were 88.0%, 100%, 92.9%, 100%, and 85.2%, respectively. The diagnostic sensitivity, specificity, accuracy, positive predictive value, and NPV of mediastinoscopy on a per-person analysis were 81.3%, 100%, 89.0%, 100%, and 78.8%, respectively. Significant differences in the sensitivity, accuracy, and NPV were evident between EBUS-TBNA and mediastinoscopy (p < 0.005). Conclusions: EBUS-TBNA was superior to mediastinoscopy in terms of its diagnostic performance for mediastinal staging of cN1–3 NSCLC. Because EBUS-TBNA is both less invasive and affords superior diagnostic sensitivity, it should be the first-line procedure performed in patients with NSCLC.
Similarity in temporal variation in sex‐biased dispersal over short and long distances in the dark‐eyed junco, Junco hyemalis

Patterns of sex‐biased dispersal (SBD) are typically consistent within taxa, for example female‐biased in birds and male‐biased in mammals, leading to theories about the evolutionary pressures that lead to SBD. However, generalizations about the evolution of sex biases tend to overlook that dispersal is mediated by ecological factors that vary over time. We examined potential temporal variation in between‐ and within‐population dispersal over an 11‐year period in a bird, the dark‐eyed junco (Junco hyemalis). We measured between‐population dispersal patterns using genetic assignment indices and found yearly variation in which sex was more likely to have immigrated. When we measured within‐population spatial genetic structure and mark–recapture dispersal distances, we typically found yearly SBD patterns that mirrored between‐population dispersal, indicating common eco‐evolutionary causes despite expected differences due to the scale of dispersal. However, in years without detectable between‐population sex biases, we found genetic similarity between nearby males within our population. This suggests that, in certain circumstances, ecological pressures may act on within‐population dispersal without affecting dispersal between populations. Alternatively, current analytical tools may be better able to detect within‐population SBD. Future work will investigate potential causes of the observed temporal variation in dispersal patterns and whether they have greater effects on within‐population dispersal.
[A multilevel study on the relationship between the residential distribution of high class (power elites) and smoking in Seoul].

OBJECTIVES We examined whether the neighborhood socioeconomic position predicts the smoking rates after adjusting for individual socioeconomic position indicators. METHODS Data were obtained from the 2001 Seoul Health Indicators Survey. The neighborhood socioeconomic position was the residential distribution of the high class (power elites), as measured by the location quotients (LQ) for each administrative dong (district). A high LO denotes a high neighborhood socioeconomic status. The individual socioeconomic position included education, occupation and income. Age-adjusted smoking rates according to the LQ level were computed with the direct method. The total number of subjects in this study (26,022 men and 28,007 women) was the reference. A multilevel logistic regression analysis was conducted with the individuals at the first level and the neighborhoods at the second level to estimate the odds ratios of smoking with 95% confidence intervals. RESULTS For men, the age-adjusted smoking rates increased with a decrease in the LQ. For women, the relationship between the age-adjusted smoking rate and the LQ was not clear. The odds of smoking for both genders were greater among those subjects with lower incomes and lower education. The manual occupational class had greater odds of smoking than the non-manual class for the males, while the odds ratio of smoking among females with a manual occupation tended to be lower than those females with a non-manual occupation. For the males, the LQ levels independently predicted smoking after adjustment for individual income. However, this relation between the LQ and smoking in males was explained by full adjustment for the individual socioeconomic position indicators (education, occupation and income). CONCLUSIONS A low level of neighborhood socioeconomic position was associated with higher smoking rates among the men residing in Seoul. This association between the neighborhood socioeconomic position and smoking in men was explained by the individual socioeconomic position. Anti-smoking efforts to reduce geographical inequality in smoking should be directed at reducing the smoking rates between the individuals with different socioeconomic backgrounds in the metropolitan city of Seoul, South Korea.
SCMA codebook design based on constellation rotation

Sparse code multiple access (SCMA) is a competitive non-orthogonal multiple access technique for the fifth generation (5G) wireless communications. The SCMA codebook design is a very essential problem. This paper presents a constellation-rotation-based method for designing codebooks for downlink SCMA system. The basic idea is to make the minimum Euclidean distance of the main-constellation as larger as possible, so as to achieve good BER (bit error rate) performance. By constructing proper sub-constellations and Latin matrix, it is able to achieve a good shaping gain. Simulation results show that the proposed SCMA codebooks provides good BER performance in both additive white Gaussian noise (AWGN) and flat fading channels.