Miracle-dz/UniFAR-FTUs huggingface dataset:
Protection from harm: the experience of adults after therapy with prolonged-speech.

BACKGROUND It is well documented that adults can control stuttering if they use certain novel speech patterns referred to generically as prolonged-speech (PS). These speech patterns were refined in the 1960s and developed into behavioural treatment programmes. The bulk of available PS treatment research has focused on speech parameters thought to reflect favourable treatment outcome. Considering this, and that post-treatment relapse is known to be common, clinicians and researchers could be usefully informed by knowledge about the experiences of those who receive these treatments. Subsequently, they could use such information in attempts to control stuttering in their clients. Yet, at present, systematic research on this topic is scant. AIMS The continued development of PS treatments could be usefully informed by research into the experiences of those who use PS to control stuttering. Hence, that is the topic of the present report. METHODS & PROCEDURES The method used was phenomenology. Participants were a purposive sample of 10 people who had received PS treatment. During a 2-year period, a collaborative approach to the study of the topic was developed between the participants and interviewer. Interviews were from 1.5 to 2 hours, and a total of 34 interviews and discussions were undertaken with participants. Transcripts of these were used to generate text from which themes were identified using line-by-line, holistic and selective approaches. OUTCOMES & RESULTS The main findings were that even after therapy with PS there is a continued risk of stuttering occurring, and although adults have the novel experience of controlling stuttering, they also continue to experience feeling different from those who do not stutter, which may be exacerbated after therapy. Given the negative consequences associated with stuttering and feeling different, the essence of the experience after therapy with PS is that adults use their own resources to integrate behavioural skills with existing experiences in order to protect themselves from the harm of stuttering as best they can. PS changes speech, but not the dynamic and often unpredictable communication situations of everyday life. Hence, the maximum benefits of PS are attained when clients use a strategic approach to control stuttered speech and daily communication. CONCLUSIONS These findings are consistent with the results of existing outcome research as well as with other current research from the present group. Their implications are discussed in relation to the structure of PS treatments as well as in relation to future PS outcome research. The clinical implications of these findings are discussed in terms of informing prospective clients of the experiential consequences of PS, selecting clients who might benefit from PS and in terms of assisting clients to achieve optimal benefits from PS.
ALZHEIMER'S DISEASE AND VASCULAR FACTORS: FACTS AND THEORIES

Although Alzheimer s disease is classified as a neurodegenerative dementia, in Alzheimer s dementia there is increasing evidence of an association with vascular risk factors and vascular pathology. These observations are supported by epidemiological and pathological studies. Vascular factors may play a significant role in the pathogenesis of Alzheimer s dementia. Further research is needed to explore this relationship. Modification of vascular risk factors could make a significant impact towards prevention and treatment of Alzheimer s disease, which is a distressing and prevalent condition in the community. This article considers the relationship of these vascular risk factors and potential mechanisms associated with the aetiopathogenesis of Alzheimer s dementia.
Adoption of E-Government among Bahraini Citizens

Many governments worldwide have been investing heavily in e-Government project as a strategy to provide the best governmental services to citizens. However, many governments and academic researchers recognized the problem of low-level of citizens' adoption toward e-Government services. Bahrain e-Government Authority is one of the governments that suffer from the lack of citizens' adoption of e-Government services, what caused serious problems to the authority. Therefore, this study is dedicated to address the factors that affect citizen's intention to adopt e-Government services from cultural, awareness and trust perspectives. Regression analysis is conducted to determine the relationship between culture, awareness and trust with adoption of e-Government. The results of the regression test showed strong evidence of a significant relationship between culture, awareness and trust and adoption of e-Government. However, the test indicated that trust had the highest level of relationship toward e-Government adoption. These results reveal that trust construct should be more considered by the e-Government authorities in Bahrain because it has a considerable impact on citizens' intention to use e-Government services. This will enable the authority to take actions to enhance citizens' trust, what will increase the rate of e-Government adopters.
Patient‐Controlled Analgesia With Nalbuphine During Labor

The effectiveness and safety of nalbuphine administered via the patient-controlled analgesia system were investigated in 82 parturients during labor. Comparison of nalbuphine via the patient-controlled system versus 66 control patients receiving the same drug via intermittent intravenous bolus injections revealed it to be safe and effective in both cases. Patients receiving nalbuphine by the pump had less drowsiness and were more satisfied with their analgesia than those in the control group. There were no differences in the frequency of fetal distress or in Apgar scores.
Building a Culturally-Competent Web Site: A Cross-Cultural Analysis of Web Site Structure

The internationalization of Web sites requires Web designers to provide effective navigation experience for users from diverse cultural backgrounds. This research investigates the effect of cultural cognitive style on user perception of Web site structure characteristics and performance on the Web site, and the subsequent user satisfaction towards the Web site. More specifically, the authors focus on the breadth versus depth of a Web site's structure. A laboratory experiment involving participants from China and the United States was conducted to test the hypotheses. The results showed that cultural cognitive style and Web site structure indeed interact to affect user perception and performance. People with holistic and analytic cultural cognitive styles displayed different perceived navigability and user performance on "broad" and "deep" Web sites. This study adds a cultural dimension to our knowledge on how Web site structure can affect users' experience. It also suggests pragmatic strategies for Web site design practitioners to improve website design in order to produce compelling navigation experience for users from diverse cultures.
Therapeutic effect of phytoecdysteroids rich extract from Ajuga iva on alloxan induced diabetic rats liver, kidney and pancreas

In the current study, the effect of Ajuga iva extract on blood glucose, lipid profile, hepatic and renal toxicity and antioxidant enzyme activities in alloxan‐induced diabetic rats was investigated. Diabetes was confirmed by measuring the glucoserua concentration 15 days after alloxan administration. Ajuga iva extract was administrated orally 3 weeks after alloxan injection. Our results investigate that Ajuga iva extract supplementation increased the levels of both enzymatic antioxidant (superoxide dismutase, catalase and gluthation peroxidase) and metals antioxidants (iron, copper, magnesium, calcuim) and decreased lipid peroxidation level (TBARs). Besides Ajuga iva ameliorated diabetes provoked hepatic and renal toxicity appeared by a lower level in total and direct bilirubin, urea, creatinine, triglyceride (TG), cholesterol and a higher level in HDL‐cholesterol. Besides, the activities of phosphatase alkalines (PAL), aspartate and lactate transaminase (AST & ALT) were decreased. The benefices effects of phytoecdysteroids of Ajuga iva confirmed by histological observation in pancreatic tissues.
Diffusive dynamics and stochastic models of turbulent axisymmetric wakes

A modelling methodology to reproduce the experimental measurements of a turbulent flow in the presence of symmetry is presented. The flow is a three-dimensional wake generated by an axisymmetric body. We show that the dynamics of the turbulent wake flow can be assimilated by a nonlinear two-dimensional Langevin equation, the deterministic part of which accounts for the broken symmetries that occur in the laminar and transitional regimes at low Reynolds numbers and the stochastic part of which accounts for the turbulent fluctuations. Comparison between theoretical and experimental results allows the extraction of the model parameters.
Biological activity of sour cherry fruit on the bacterial flora of human saliva in vitro.

Maria Hevesi1*, Anna Blazovics2, Erzsebet Kallay3, Anita Vegh1, Monika Steger-Mate4, Gitta Ficzek1 and Magdolna Toth1 Corvinus University of Budapest, Faculty of Horticultural Science, Department of Pomology, Villanyi ut 29–43, HU-1118 Budapest, Hungary Semmelweis University, Department of Pharmacognosy, Ullo”i ut 26, HU-1085 Budapest, Hungary Research Institute for Fruit Growing and Ornamentals, Park u. 2, HU-1223 Budapest–Erd, Hungary Corvinus University of Budapest, Faculty of Food Science, Department of Food Preservation, Menesi ut 43–45, HU-1118 Budapest, Hungary
Risk Management during Requirements

Risk management is project management for adults. This means the manager adopts an adult attitude toward things that might go wrong during the project, a marked difference from the prevailing can-do attitude. The risk manager is obliged to do some cannot-do thinking, to look problems - even potentially unsolvable ones - directly in the eye and acknowledge that they could come to pass. The risk-aware project manager will accept a lucky break if it should happen but refuses to include it in the plan. At the heart of risk management is a public, continuing process of risk identification. Some risks that will threaten your project are utterly unique to your situation, but others are not. Over some 10 years of conducting risk identification exercises in organizations, we have found five risks that are so ubiquitous that we have dubbed them core risks. We focus on the first two core risks and discuss risk management as part of the requirements process: intrinsic schedule flaws-estimates that are wrong (undoable) from day one, often based on nothing more than wishful thinking; and specification breakdown - failure to achieve stakeholder consensus on what to build.
Lord of the Rings: animation that was not there

The need to recreate reality is a driving force behind art. Mimesis-imitation of the real world as a main function of art was observed and analyzed as early as the fourth century B. C. by Socrates, Plato, and Aristotle. Although artists searched for inner inspiration, the psychological need to record reality was always present, appearing during the renaissance, in baroque painting, the art of film, and probably reaching it's most sophisticated form in computer graphics and animation. Seventy years ago, Polish critic Karol Irzykowski, in his book "The 10th Muse", predicted that one day animated film would evolve into the most important film genre of the future. He also contemplated the possibility of animation reaching a state of realism in which it could show "ordinary things and people". He would be surprised to learn how true his words were to become. Digital media has given us an opportunity to go even further towards that goal of "registering reality". In this sketch, I present these concepts in relation to Digital Domain's work on New Line Cinema's release of J. R. R. Tolkien's classic tale "Lord of the Rings: Fellowship of the Ring".
EspD Is Critical for the Virulence-Mediating ESX-1 Secretion System in Mycobacterium tuberculosis

ABSTRACT ESAT-6 system 1 (ESX-1)-mediated secretion in Mycobacterium tuberculosis is dependent on proteins encoded by the cotranscribed espA-espC-espD gene cluster. While the roles of EspA and EspC with respect to the ESX-1 secretion system have been actively investigated, the function of EspD remains unknown. We show that EspD is secreted by M. tuberculosis, but unlike EspA and EsxA, its export does not exclusively require the ESX-1 system. Evidence for stabilization of cellular levels of EspA and EspC by EspD is presented, and depletion of EspD results in loss of EsxA secretion. Site-directed mutagenesis of EspD reveals that its role in the maintenance of cellular levels of EspA in M. tuberculosis is distinct from its facilitation of EsxA secretion. The same mutagenesis experiments have also shown that secretion of EspD is not required for the secretion of EsxA. Our findings highlight a critical and complex role for EspD in modulating the ESX-1 secretion system in M. tuberculosis.
Resident Advisor General Intelligence, Emotional Intelligence, Personality Dimensions, and Internal Belief Characteristics as Predictors of Rated Performance

Resident Advisors (RAs) have a significant hand in helping students adjust and thrive in college life. Given the importance of selecting high-performing RAs, this study sought to examine how well various measures of intelligence (e.g., general, emotional) as well as personality and additional “internal belief” characteristics predict performance in the RA position, using hierarchical regression analyses. General intelligence, emotional intelligence, personality dimensions, and “internal beliefs” survey data was obtained from 36 university RAs. Performance data was obtained from self-reports by the RAs and also from 190 resident students rating their RAs. RA emotional stability, conscientiousness, and confidence in ability as an RA were found to be predictive of rated performance. Scores of emotional intelligence, but not general intelligence, were found to be significantly positively correlated with RA performance. However, emotional intelligence did not have incremental validity above the contribution of other measures. Implications for improving the current process of RA selection at colleges and directions for future research are discussed. Predictors of RA Performance 4 Resident Advisor General Intelligence, Emotional Intelligence, Personality Dimensions, and Internal Belief Characteristics as Predictors of Rated Performance The college experience is a tumultuous time in young people’s lives. Being away from home for the first time, meeting high academic expectations, and potentially facing financial concerns create a situation loaded with tension. Additionally, parents often feel shut out from their children’s lives and unsure of how to help them during this difficult transition period (Kadison & DiGeronimo, 2004). In the face of these pressures, college students may feel hopeless and helpless, resulting in problems such as depression, sleep disorders, substance abuse, anxiety disorders, eating disorders, impulsive behaviors, and suicide (Kadison & DiGeronimo). Fortunately, the transition to autonomy can be greatly facilitated by the guidance of capable peers. Indeed, many studies from the field of social psychology confirm that during the adolescent stage of development, teens tend to be most heavily influenced by their peers (Myers, 2007). Recognizing this fact, most universities employ undergraduate students as leaders in important contexts of the college environment. For example, Resident Advisors (RAs) are students employed by universities to live in specific student housing and supervise students. RAs are typically charged with four major tasks: (i) maintaining campus residence halls, (ii) enforcing residential policies, (iii) developing community, and (iv) assisting students. In addition, they are often viewed as role models by fellow students in the residence halls where they live and work, as they interact daily with fellow students (Healea,
Induction therapy of AML with ara-C plus daunorubicin versus ara-C plus gemtuzumab ozogamicin: a randomized phase II trial in elderly patients.

BACKGROUND Chemotherapy for elderly patients with acute myeloid leukemia (AML) results in a median overall survival (OS) of ≤ 1 year. Elderly patients often present with cardiac comorbidity. Gemtuzumab ozogamicin (GO) is active in elderly (≥ 60 years) patients with relapsed AML with low cardiac toxicity. PATIENTS AND METHODS This randomized phase II study compared a standard combination of ara-C and daunorubicin (DNR; 7+3) versus ara-C plus gemtuzumab ozogamicin (7+GO) as the first course of induction therapy. Primary objectives were comparison of blast clearance on day 16, event-free survival (EFS), and remission duration. OS, complete remission (CR), and tolerability were secondary objectives. RESULTS One hundred and nineteen patients with de novo AML, treatment-related AML, AML with a history of myelodysplastic syndrome (MDS), or high-risk MDS entered the study. Median age of 115 patients (intent-to-treat population) was 69 years. Protocol outlined a second course 7+3 for patients without blast clearance and two courses of high-dose ara-C consolidation upon CR. Both treatments were equally effective in blast clearance, CR, EFS, remission duration, or OS (median: 7+3, 9 months; 7+GO, 10 months). Induction death rate was higher in the GO group due to veno-occlusive disease. CONCLUSION The study did not show significant superiority of 7+GO over standard 7+3.
Abdominal Ventral Hernia Repair With Current Biological Prostheses: An Experimental Large Animal Model

Biologic prostheses have emerged to address the limitations of synthetic materials for ventral hernia repairs; however, they lack experimental comparative data. Fifteen swine were randomly assigned to 1 of 3 bioprosthetic groups (DermaMatrix, AlloDerm, and Permacol) after creation of a full thickness ventral fascial defect. At 15 weeks, host incorporation, hernia recurrence, adhesion formation, neovascularization, inflammation, and biomechanical properties were assessed. No animals had hernia recurrence or eventration. DermaMatrix and Alloderm implants demonstrated more adhesions, greater inflammatory infiltration, and more longitudinal laxity, but near identical neovascularization and tensile strength to Permacol. We found that porcine acellular dermal products (Permacol) contain following essential properties of an ideal ventral hernia repair material: low inflammation, less elastin and stretch, lower adhesion rates and cost, and more contracture. The addition of lower cost xenogeneic acellular dermal products to the repertoire of available acellular dermal products demonstrates promise, but requires long-term clinical studies to verify advantages and efficacy.
Application of magnetic resonance spectroscopy in geriatric mood disorders

Abstract The prevalence of mood disorders in the rapidly-growing older adult population merits attention due to the likelihood of increased medical comorbidities, risk of hospitalization or institutionalization, and strains placed on caregivers and healthcare providers. Magnetic resonance spectroscopy (MRS) quantifies biochemical compounds in vivo, and has been used specifically for analyses of neural metabolism and bioenergetics in older adults with mood disorders, usually via proton or phosphorous spectroscopy. While yet to be clinically implemented, data gathered from research subjects may help indicate potential biomarkers of disease state or trait or putative drug targets. Three prevailing hypotheses for these mood disorders are used as a framework for the present review, and the current biochemical findings within each are discussed with respect to particular metabolites and brain regions. This review covers studies of MRS in geriatric mood disorders and reveals persisting gaps in research knowledge, especially with regard to older age bipolar disorder. Further MRS work, using higher field strengths and larger sample sizes, is warranted in order to better understand the neurobiology of these prevalent late-life disorders.
Different mechanisms involved in interhemispheric transfer of visuomotor information

Twenty-one subjects underwent event-related fMRI while carrying out a simple visuomotor task in which they responded to stimuli flashed either onto the right visual field, onto the left visual field, or onto both visual fields at once. The aim of this study was to clarify areas of brain activity associated with crossed-uncrossed differences (CUD) and to investigate differences of the brain activity between CUD and redundancy gain. An intriguing brain activation related to CUD was found in the genu of the corpus callosum (CC). The sites of activation related to redundancy gain were the extrastriate cortex and the cingulate cortex. Our results suggested that CUD depended on the interhemispheric transfer via the CC, and that CUD and redundancy gain involved different brain mechanisms.
Passive High-speed Imaging of Ion Acoustic Turbulence in a Hollow Cathode

A passive, non-invasive plasma diagnostic is developed and validated to estimate the dispersion of electric propulsion plasmas. This new technique uses a Silicon photomultiplier (SiPM) to measure fluctuations in light intensity to estimate the dispersion of the plasma. Experimental validation of the technique was conducted on a hollow cathode. Ion acoustic waves, which are responsible for the anomalous resistivity of the cathode plume, were measured using both ion saturation probes and the SiPM technique. The results from the SiPM were compared to measurements from ion saturation probes. While the raw data and power spectra acquired with the SiPM were different, the estimated dispersion and phase velocity are within uncertainty of each other and within uncertainty of similar measurements found in the literature.
“Facilitating optimal motivation and psychological well-being across life’s domains”: Correction to Deci and Ryan (2008).

Self-determination theory (SDT) differentiates motivation, with autonomous and controlled motivations constituting the key, broad distinction. Research has shown that autonomous motivation predicts persistence and adherence and is advantageous for effective performance, especially on complex or heuristic tasks that involve deep information processing or creativity. Autonomous motivation is also reliably related to psychological health. Considerable research has found interpersonal contexts that facilitate satisfaction of the basic psychological needs for competence, autonomy, and relatedness to enhance autonomous motivation, which comprises intrinsic motivation and well-internalized extrinsic motivation. SDT has been applied in varied cultures and in many life domains, and research is reviewed that has related autonomous and controlled motivation to education, parenting, work, health care, sport, and close relationships.
A millimeter miss is as good as a thousand miles: The role of accurate target localization in lung stereotactic body radiation therapy.

Surgical intervention with lobectomy and mediastinal lymph node dissection is considered the treatment of choice in early stage non-small cell lung cancer (NSCLC) (1). However, approximately 20-25% of patients with early stage NSCLC are poor surgical candidates for lobectomy because of concomitant severe cardiac or pulmonary co-morbidities. For these patients, conventional radiotherapy with 60 to 70 Gy delivered in 30-35 fractions over a 6-7-week period generally resulted in poor 20-40% 3-year and 10-30% 5-year survival rates (2,3). This inadequate tumor control is mainly due to the insufficient tumor dose that is limited by normal tissue toxicity and possible target-miss caused by tumor mobility.