Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparison of 4 diets of varying glycemic load on weight loss and cardiovascular risk reduction in overweight and obese young adults: a randomized controlled trial.

BACKGROUND Despite the popularity of low-glycemic index (GI) and high-protein diets, to our knowledge no randomized, controlled trials have systematically compared their relative effects on weight loss and cardiovascular risk. METHODS A total of 129 overweight or obese young adults (body mass index, > or =25 [calculated as weight in kilograms divided by the square of height in meters]) were assigned to 1 of 4 reduced-fat, high-fiber diets for 12 weeks. Diets 1 and 2 were high carbohydrate (55% of total energy intake), with high and low GIs, respectively; diets 3 and 4 were high protein (25% of total energy intake), with high and low GIs, respectively. The glycemic load was highest in diet 1 and lowest in diet 4. Changes in weight, body composition, and blood chemistry profile were studied. RESULTS While all groups lost a similar mean +/- SE percentage of weight (diet 1, -4.2% +/- 0.6%; diet 2, -5.5% +/- 0.5%; diet 3, -6.2% +/- 0.4%; and diet 4, -4.8% +/- 0.7%; P = .09), the proportion of subjects in each group who lost 5% or more of body weight varied significantly by diet (diet 1, 31%; diet 2, 56%; diet 3, 66%; and diet 4, 33%; P = .01). Women on diets 2 and 3 lost approximately 80% more fat mass (-4.5 +/- 0.5 [mean +/- SE] kg and -4.6 +/- 0.5 kg) than those on diet 1 (-2.5 +/- 0.5 kg; P = .007). Mean +/- SE low-density-lipoprotein cholesterol levels declined significantly in the diet 2 group (-6.6 +/- 3.9 mg/dL [-0.17 +/- 0.10 mmol/L]) but increased in the diet 3 group (+10.0 +/- 3.9 mg/dL [+0.26 +/- 0.10 mmol/L]; P = .02). Goals for energy distribution were not achieved exactly: both carbohydrate groups ate less fat, and the diet 2 group ate more fiber. CONCLUSION Both high-protein and low-GI regimens increase body fat loss, but cardiovascular risk reduction is optimized by a high-carbohydrate, low-GI diet.
Intraventricular conduction defects in patients with congestive heart failure: left but not right bundle branch block is an independent predictor of prognosis. A report from the Italian Network on Congestive Heart Failure (IN-CHF database).

BACKGROUND In industrialized countries the prevalence of congestive heart failure (CHF) is increasing. Many clinical factors have been shown to influence the prognosis of CHF. The effect of a wide QRS on mortality is debated; while left bundle branch block (LBBB) has been already identified as a negative prognostic factor, the effect of right bundle branch block (RBBB) is still unknown. The aim of this study was to compare the association of these two intraventricular conduction defects on the prognosis of CHF. METHODS Data were derived from the Italian Registry of CHF. Entry in the Registry required that patients had a diagnosis of CHF based on the European Society of Cardiology guidelines. We analyzed the 1-year follow-up data of 5517 outpatients with CHF of different etiologies. The presence of a wide QRS was defined if the duration was > 120 ms. RESULTS A wide QRS was present in 2066 patients (37.5%), 25.2% with LBBB, 6.1% with RBBB, 6.2% with other intraventricular defects. At univariate analysis patients with complete LBBB had a significantly higher 1-year mortality than those without (16.1 vs 11.9%) but this was not true for complete RBBB (11.9 vs 11.9%). Even after multivariate adjustment, complete LBBB still remained an independent predictor of death (relative risk 1.36, 95% confidence interval 1.15-1.61). CONCLUSIONS LBBB but not RBBB is an independent predictor of death in CHF.
LPLI inhibits apoptosis upstream of Bax translocation via a GSK‐3β‐inactivation mechanism

Low‐power laser irradiation (LPLI), a non‐damage physical therapy, which has been used clinically for decades of years, is shown to promote cell proliferation and prevent apoptosis. However, the underlying mechanisms that LPLI prevents cell apoptosis remain undefined. In this study, based on real‐time single‐cell analysis, we demonstrated for the first time that LPLI inhibits staurosporine (STS)‐induced cell apoptosis by inactivating the GSK‐3β/Bax pathway. LPLI could inhibit the activation of GSK‐3β, Bax, and caspase‐3 induced by STS. In the searching for the mechanism, we found that, LPLI can activate Akt, which was consistence with our former research, even in the presence of STS. In this anti‐apoptotic process, the interaction between Akt and GSK‐3β increased gradually, indicating Akt interacts with and inactivates GSK‐3β directly. Conversely, LPLI decreased the interaction between GSK‐3β and Bax, with the suppression of Bax translocation to mitochondria, suggesting LPLI inhibits Bax translocation through inactivating GSK‐3β. These results were further confirmed by the experiments of co‐immunoprecipitation. Wortmannin, an inhibitor of phosphatidylinositol 3′‐OH kinase (PI3K), potently suppressed the activation of Akt and subsequent anti‐apoptotic processes induced by LPLI. Taken together, we conclude that LPLI protects against STS‐induced apoptosis upstream of Bax translocation via the PI3K/Akt/GSK‐3β pathway. These findings raise the possibility of LPLI as a promising therapy for neuron‐degeneration disease induced by GSK‐3β. J. Cell. Physiol. 224:218–228, 2010 © 2010 Wiley‐Liss, Inc.
Clinical evaluation of the use of locally delivered chlorhexidine in periodontal maintenance therapy.

BACKGROUND The objective of this study was to evaluate clinically the effectiveness of a chlorhexidine gluconate chip in sites still showing signs of disease during periodontal maintenance therapy. METHODS Forty-two maintenance non-smoking patients (previously treated with non-surgical scaling and root planing [SRP]), presenting at least one probing depth (PD) of 5 to 8 mm, and bleeding on probing (BOP) at single-rooted teeth were assigned randomly to two groups: treated with a chlorhexidine gluconate chip (CHIP group) and treated with SRP (SRP group). Patients were assessed for plaque index, gingival index, BOP, PD, clinical attachment level (CAL), and gingival recession at baseline, 6 weeks, and 3 and 6 months. RESULTS Both treatments resulted in improvements in all parameters evaluated. After 6 months, a reduction in PD of 2.64 +/- 0.02 mm and 2.12 +/- 0.02 mm was observed for CHIP and SRP groups, respectively (P >0.05). The observed gain in CAL was 2.19 +/- 0.87 mm and 2.07 +/- 1.53 mm for CHIP and SRP groups, respectively (P >0.05). In deep pockets, PD reduction was 3.60 +/- 0.70 mm for CHIP group and 2.83 +/- 0.62 mm for SRP group (P = 0.01). CONCLUSIONS Both treatments were equally effective in periodontal health reestablishment in inflamed single-root sites of maintenance patients. However, for deep pockets, the chlorhexidine gluconate chip was more effective than SRP in reducing PD.
On Millimeter Wave and THz Mobile Radio Channel for Smart Rail Mobility

As a widely acknowledged efficient and green transportation model, rail traffic is expected to evolve into a new era of “smart rail mobility” whereby infrastructure, trains, and travelers will be interconnected to achieve optimized mobility, higher safety, and lower costs. Thus, a seamless high-data rate wireless connectivity with up to dozens of gigahertz bandwidth is required. Such a huge bandwidth requirement motivates the exploration of the underutilized millimeter (mm) wave and terahertz (THz) bands. In this paper, the motivations for developing millimeter wave and THz communications for railway are clarified by first defining the applications and scenarios required for smart rail mobility. Ray-tracing simulations at 100 GHz imply that to form high-gain directional antenna beams, dynamic beamforming strategies and advanced handover design are critical for the feasibility of THz communications to enable smart rail mobility.
Design considerations for wireless underwater communication transceiver

Evolutionary processes have shaped acoustic communication behaviours of remarkable complexity, for thus many researches have led to the development of innovative receiver structures for robust underwater acoustic communication. As underwater channel model, attenuation, transmission distance, low power consumption, highly Signal to Noise Ratio, Bit Error Ratio, inter-symbol interference, error coding and alternative modulation strategies, are of primary concern in the whole study and in particularly the proposition of the transceiver structure and his design. The values of these parameters above - mentioned are crucial to improve the wireless underwater communication. In addition, the battery powered Network nodes limit the life time of the proposed transceiver. This paper aims to survey the existing and the reliability of this transceiver and its applicability to underwater communication based on these simulations parameters values that are evaluated and presented.
Changeability of the fully methylated status of the 15q11.2 region in induced pluripotent stem cells derived from a patient with Prader‐Willi syndrome

Prader‐Will syndrome (PWS) is characterized by hyperphagia, growth hormone deficiency and central hypogonadism caused by the dysfunction of the hypothalamus. Patients with PWS present with methylation abnormalities of the PWS‐imprinting control region in chromosome 15q11.2, subject to parent‐of‐origin‐specific methylation and controlling the parent‐of‐origin‐specific expression of other paternally expressed genes flanking the region. In theory, the reversal of hypermethylation in the hypothalamic cells could be a promising strategy for the treatment of PWS patients, since cardinal symptoms of PWS patients are correlated with dysfunction of the hypothalamus. The genome‐wide methylation status dramatically changes during the reprograming of somatic cells into induced pluripotent stem cells (iPSCs) and during the in vitro culture of iPSCs. Here, we tested the methylation status of the chromosome 15q11.2 region in iPSCs from a PWS patient using pyrosequencing and a more detailed method of genome‐wide DNA methylation profiling to reveal whether iPSCs with a partially unmethylated status for the chromosome 15q11.2 region exhibit global methylation aberrations. As a result, we were able to show that a fully methylated status for chromosome 15q11.2 in a PWS patient could be reversed to a partially unmethylated status in at least some of the PWS‐iPSC lines. Genome‐wide DNA methylation profiling revealed that the partial unmethylation occurred at differentially methylated regions located in chromosome 15q11.2, but not at other differentially methylated regions associated with genome imprinting. The present data potentially opens a door to cell‐based therapy for PWS patients and, possibly, patients with other disorders associated with genomic imprinting.
The long‐term outcome of transvaginal anterior levatorplasty for intractable rectovaginal fistula

Several procedures have been described for rectovaginal fistula with a wide range of success, but there is little information on the long‐term outcome. The aim of the present study was to investigate the long‐term outcome after transvaginal anterior levatorplasty (ALP) for intractable rectovaginal fistula.
Neuroendocrine gastro-enteropancreatic tumors – from eminence based to evidence-based medicine – A Scandinavian view

Abstract Neuroendocrine tumors (NETs) comprise a heterogenous group of neoplasms with variable clinical expression and progression. The primary tumors most frequently occur in the lungs, intestine and the pancreas. The NET incidence is approximately 6.1/100,000 per year with a prevalence higher than 35/100,000 per year. A NET may be functioning with symptoms related to hormone overproduction or non-functioning, not presenting any hormone-related symptoms. From the early 1980s and onwards, Uppsala University Hospital has contributed significantly to diagnosis, just to mention immunohistochemistry, radio-immunoassays for hormones and peptides and molecular imaging. On the therapeutic side, treatments with cytotoxics as well as biologicals such as, somatostatin analogs and interferons have been evaluated. We have furthermore been involved in important phase III trials for registration of so called, new targeted agents such as, RADIANT-3 and RADIANT-2. Our group were also the first to localize the gene for MEN I on chromosome 11 locus q13. Most recent developments have been the establishments of new biomarkers such as, olfactory receptor E51E1 as well as micro-RNAs in carcinoid tumors of the intestine and lung. A new oncolytic virus, Ad-Vince, for treatment of most NETs has been developed and is ready for the clinic. Furthermore, we have been involved in establishing Nordic and international collaborations. Today, NETs is an area with rapid development and recognized by international organizations at conferences, with large attendance. The Nordic countries continue to be significant contributors to the field.
Increased oxygen radical production determined by whole blood chemiluminescence in patients with previous yersinia arthritis

Luminol‐dependent whole blood chemiluminescence (CL) was studied in patients with previous yersinia arthritis (YA). Patients showed significantly higher CL responses compared to healthy controls regardless of HLA‐B27 antigen when either N‐formyl‐methionyl‐leucyl‐phenylalanine or opsonized zymosan particles were used a stimulus. This hyperreactivity may well play a role in the development of inflammatory injury in YA.
A randomized, double-blind study of phenytoin for the prevention of post-traumatic seizures.

BACKGROUND Antiepileptic drugs are commonly used to prevent seizures that may follow head trauma. However, previous controlled studies of this practice have been inconclusive. METHODS To study further the effectiveness of phenytoin (Dilantin) in preventing post-traumatic seizures, we randomly assigned 404 eligible patients with serious head trauma to treatment with phenytoin (n = 208) or placebo (n = 196) for one year in a double-blind fashion. An intravenous loading dose was given within 24 hours of injury. Serum levels of phenytoin were maintained in the high therapeutic range (3 to 6 mumol of free phenytoin per liter). Follow-up was continued for two years. The primary data analysis was performed according to the intention to treat. RESULTS Between drug loading and day 7, 3.6 percent of the patients assigned to phenytoin had seizures, as compared with 14.2 percent of patients assigned to placebo (P less than 0.001; risk ratio, 0.27; 95 percent confidence interval, 0.12 to 0.62). Between day 8 and the end of year 1, 21.5 percent of the phenytoin group and 15.7 percent of the placebo group had seizures; at the end of year 2, the rates were 27.5 percent and 21.1 percent, respectively (P greater than 0.2 for each comparison; risk ratio, 1.20; 95 percent confidence interval, 0.71 to 2.02). This lack of a late effect could not be attributed to differential mortality, low phenytoin levels, or treatment of some early seizures in patients assigned to the placebo group. CONCLUSIONS Phenytoin exerts a beneficial effect by reducing seizures only during the first week after severe head injury.
Candidate traits in elections: when good news for selection is bad news for accountability

Abstract We analyze a two-election political agency model with moral hazard and adverse selection in which candidates have observable traits such as job qualifications that help voters to imperfectly predict politicians' types. Candidate's traits can help voters select good types of politicians. However, selecting candidates with good traits can reduce accountability because the voter cannot commit to throw out politicians with good traits who produce bad outcomes. This result explains when and why voters may sometimes select candidates who they believe are less likely to be competent.
Growth Factors , Cytokines , Cell Cycle Molecules Contribution of Macrophages to Angiogenesis Induced by Vascular Endothelial Growth Factor Receptor-3-Specific Ligands

From the Schepens Eye Research Institute,* Harvard Medical School, Boston, Massachusetts; the Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, Korea; the Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts; and the Department of Molecular Cell Biology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
An LTI Model-Based Study on Reflected Power Canceler for FMCW Radars

Frequency modulation continuous wave (FMCW) radar receivers generally suffer from transmitter leakage due to insufficient TX-to-RX isolation. One of the effective approaches to solving this problem is using reflected power cancelers (RPCs) that cancel the leakage from the transmitter adaptively. In this paper, a linear time invariant (LTI) model of the RPC is derived in order to carry out a comprehensive study of the mechanism of leakage cancelation and output noise performance for CW radar applications. Loop frequency responses for receiving signal, loop stability, and the influence of dc offset of IQ mixer are analyzed by a simplified transfer function. A detailed noise model of the RPC is established based on the LTI model to study the output noise components of the RPC under a large incident leakage, then the internal noise cancelation mechanism is elucidated. A prototype with its operating frequency range from 820 to 1020 MHz at UHF band is implemented. Measured loop frequency responses are in agreement with simulation results obtained with the proposed model. Furthermore, measured cancelation ratios for leakages of different ramp rates comply with the normalized power gain at corresponding frequency offsets. The input-referred receiving noise of the RPC prototype is measured to be −155 dBm/Hz at 100-kHz offset under +10-dBm incident leakage power. The proposed LTI model provides a useful tool for the design of high-performance RPC for FMCW systems in different application environments.
MLPA as first screening method for the detection of microduplications and microdeletions in patients with X-linked mental retardation

Purpose: Routine protocols for the study of mental retardation include karyotype, analysis for fragile X syndrome, and subtelomeric rearrangements. Nevertheless, detection of cryptic rearrangements requires more sensitive techniques. Mutation screening in all known genes responsible for X-linked mental retardation is not feasible, and linkage analysis is sometimes limited. Multiplex ligation probe amplification is a recently developed technique based on the amplification of specific probes that allows relative quantification of 40 to 46 different target DNA sequences in a single reaction.Methods: In the present study, we assessed multiplex ligation probe amplification for the detection of microduplications/microdeletions in 80 male patients with suspicion of X-linked mental retardation.Results: We detected four copy number aberrations (5%): three duplications (GDI1, RPS6KA3, and ARHGEF6) and one deletion (OPHN1). All these changes were confirmed by other molecular techniques, and patients were clinically re-evaluated.Conclusions: We strongly recommend the use of multiplex ligation probe amplification as a first screening method for the detection of copy number aberrations in patients with mental retardation because of its cost-effectiveness.
Genome‐wide gene expression profiling in GluR1 knockout mice: key role of the calcium signaling pathway in glutamatergically mediated hippocampal transmission

α‐Amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionic acid receptors (AMPARs) convey fast synaptic transmission in the CNS and mediate various forms of hippocampal plasticity. Disruption of glutamate receptor type 1 (GluR1), a member of the AMPAR family, causes synaptic alterations and learning/memory deficits in mice. To gain mechanistic insight into the synaptic and behavioral changes associated with GluR1 deletion, hippocampal genome‐wide expression profiling was conducted using groups of GluR1 knockout (KO) mice and their wild‐type littermates. Regulation of 38 genes was found to be altered more than 30% (P < 0.01, n = 8), and seven of these genes were studied with additional quantitative experiments. A large portion of the altered genes encoded molecules involved in calcium signaling, including calcium channel components, calcium‐binding proteins and calcium‐calmodulin‐dependent protein kinase II subunits. At the protein level, we further evaluated some genes in the calcium pathway that were altered in GluR1 KO mice. Protein levels of two key molecules in the calcium pathway – GluR, ionotropic, N‐methyl‐d‐aspartate‐1 and calcium/calmodulin‐dependent protein kinase II alpha – showed similar changes to those observed in mRNA levels. These findings raise the possibility that calcium signaling and other plasticity molecules may contribute to the hippocampal plasticity and behavioral deficits observed in GluR1 KO mice.
Future supply and demand for oncologists : challenges to assuring access to oncology services.

PURPOSE To conduct a comprehensive analysis of supply of and demand for oncology services through 2020. This study was commissioned by the Board of Directors of ASCO. METHODS New data on physician supply gathered from surveys of practicing oncologists, oncology fellows, and fellowship program directors were analyzed, along with 2005 American Medical Association Masterfile data on practicing medical oncologists, hematologists/oncologists, and gynecologic oncologists, to determine the baseline capacity and to forecast visit capacity through 2020. Demand for visits was calculated by applying age-, sex-, and time-from-diagnosis-visit rate data from the National Cancer Institute's analysis of the 1998 to 2002 Surveillance, Epidemiology and End Results (SEER) database to the National Cancer Institute's cancer incidence and prevalence projections. The cancer incidence and prevalence projections were calculated by applying a 3-year average (2000-2002) of age- and sex-specific cancer rates from SEER to the US Census Bureau population projections released on March 2004. The baseline supply and demand forecasts assume no change in cancer care delivery and physician practice patterns. Alternate scenarios were constructed by changing assumptions in the baseline models. RESULTS Demand for oncology services is expected to rise rapidly, driven by the aging and growth of the population and improvements in cancer survival rates, at the same time the oncology workforce is aging and retiring in increasing numbers. Demand is expected to rise 48% between 2005 and 2020. The supply of services provided by oncologists during this time is expected to grow more slowly, approximately 14%, based on the current age distribution and practice patterns of oncologists and the number of oncology fellowship positions. This translates into a shortage of 9.4 to 15.0 million visits, or 2,550 to 4,080 oncologists-roughly one-quarter to one-third of the 2005 supply. The baseline projections do not include any alterations based on changes in practice patterns, service use, or cancer treatments. Various alternate scenarios were also developed to show how supply and demand might change under different assumptions. CONCLUSIONS ASCO, policy makers, and the public have major challenges ahead of them to forestall likely shortages in the capacity to meet future demand for oncology services. A multifaceted strategy will be needed to ensure that Americans have access to oncology services in 2020, as no single action will fill the likely gap between supply and demand. Among the options to consider are increasing the number of oncology fellowship positions, increasing use of nonphysician clinicians, increasing the role of primary care physicians in the care of patients in remission, and redesigning service delivery.