Miracle-dz/UniFAR-FTUs huggingface dataset:
Influence of Framing Information and Disposition Effect in Decision of Investment: Experimental Study on Investor Behavior at Indonesia Stock Exchange Representative on Denpasar, Bali

This study aims to examine framing information, disposition effect and interaction between the two on investment decisions made by investors by predicting stock prices. This study uses 2 × 2 between subject experimental design. Participants amounted to 80 individual investors listed as investors in securities companies in Denpasar, Bali. This study involved 80 individual investors of Bali local community based on nonprobability sampling method with purposive sampling technique. Participants were grouped into 4 experimental groups according to a combination of manipulations.The results showed some important findings. First, information framing is one factor that determines investor behavior in making investment decisions. Positively and negatively framed information will lead to different decision-making patterns. Investors who are given a positive information framing will predict stock prices higher than investors given negative information framing. Secondly, this study confirms that information received by investors contributes to the maximum effect of disposition, furthermore the effect of this disposition is influenced by the framing of information received. Third, the interaction between groups of participants who were given different information framing showed a real difference, except the group of participants given negative information indicating the existence of cognitive style differences which are psychological dimensions that represent the consistency of individuals in collecting and processing information and in decision making. This study also proves that there is no difference in behavior in making investment decisions based on gender and investment experience whereas there is a difference in the level of participants' education. Unique results were found in women participants who had different attitudes toward risk and benefit. Overall participants are posttraditional Balinese people who keep the wisdom of local Balinese culture but are in touch with global culture through stock investment.
Development and Validation of an ELISA Method for Detection of Growth Arrest Specific 6 (GAS6) Protein in Human Plasma

Abstract Gas6 protein is possibly involved in human diseases, but a validated plasma assay is lacking. So, we developed a sandwich enzyme‐linked immunosorbent assay (ELISA) method using commercially available reagents. An appropriate plasma‐based matrix was prepared to optimize the assay. The ELISA method showed inter‐ and intra‐assay coefficients of variation lower than 15%. Recoveries all fell within 15% of expected values. Plasma Gas6 concentration in 61 healthy donors was 20.3±3.8 ng/mL. Our assay meets FDA requirements for precision and accuracy for the validation of bioanalytical methods and it is suitable for research or diagnostic purposes.
Governance of Tunnelling in Developing Countries: Evidence from Bangladesh

Tunnelling (also known as self-dealing transactions) are non-arm’s length transactions with related parties of controlling shareholders for private benefit at the cost of other shareholders. Tunnelling is a governance issue between controlling shareholders and minority shareholders in both developed and developing countries. However, most studies on tunnelling are in developed countries with the few exceptions of studies in China, India and Mexico. Using Oliver Williamson’s Market and Hierarchy model this paper theoretically analyses the suitability of the governance of tunnelling in Bangladesh. Interviewing directors, independent directors and audit committee members, this study identifies the limitation and factors that affect the implementation and enforcement of current governance requirements for restricting tunnelling practices in Bangladesh. <br><br>
EVIDENCE OF INVOLVEMENT OF TUMOR NECROSIS FACTOR IN ADVERSE REACTIONS DURING TREATMENT OF KIDNEY ALLOGRAFT REJECTION WITH ANTITHYMOCYTE GLOBULIN

Serial plasma concentrations of the pyrogenic cytokines tumor necrosis factor and interleukin-1 beta were measured during treatment of acute renal allograft rejection with antithymocyte globulin in 7 consecutive kidney transplant recipients. TNF and IL-1 beta were measured with specific enzyme-linked immunosorbent assays. In 6 of 7 patients TNF could not be detected in the plasma before the start of the ATG infusion. During the first ATG infusion, which was accompanied by fever and other side effects in all patients, plasma TNF levels were shown to be elevated, ranging between 100 and 700 pg/ml. During the second ATG infusion, when side effects were minimal or absent, plasma TNF levels were only slightly raised. Circulating IL-1 beta could not be detected in any of the patients before or during ATG infusion. Additional experiments showed that TNF is rapidly secreted in cultures of peripheral blood mononuclear cells incubated with both ATG and the monoclonal antibody OKT3. These findings suggest that side effects, including fever and chills, during antilymphocyte antibody infusion are related to increased plasma levels of the pyrogenic cytokine TNF.
Mutational analysis of BRCA 1 / 2 in a group of 134 consecutive ovarian cancer patients . Novel and recurrent BRCA 1 / 2 alterations detected by next generation sequencing

The importance of proper mutational analysis of BRCA1/2 in individuals at risk for hereditary breast and ovarian cancer syndrome is widely accepted. Standard genetic screening includes targeted analysis of recurrent, populationspecific mutations. The purpose of the study was to establish the frequency of germline BRCA1/2 mutations in a group of 134 unrelated patients with primary ovarian cancer. Next generation sequencing analysis revealed a presence of 20 (14.9 %) mutations, where 65 % (n=13) were recurrent BRCA1 alterations included in the standard diagnostic panel in northern Poland. However, the remaining seven BRCA1/2 mutations (35 %) would be missed by the standard approach and were detected in unique patients. A substantial proportion (n=5/12; 41 %) of mutation-positive individuals with complete family history reported no incidence of breast or ovarian cancer in their relatives. This observation, together with the raising perspectives for personalized therapy targeting BRCA1/2 signaling pathways indicates the necessity of comprehensive genetic screening in all ovarian cancer patients. However, due to the limited sensitivity of the standard genetic screening presented in this study (65 %) an application of next generation sequencing in molecular diagnostics of BRCA1/2 genes should be considered.
Immune Dysregulation and Chronic Stress among Older Adults: A Review

Aging is associated with a natural dysregulation in immune functioning which may be amplified when it occurs in the context of chronic stress. Family dementia caregiving provides an excellent model to study the impact of chronic stress on immune functioning among older individuals. Empirical data suggest that the stress of caregiving dysregulates multiple components of innate and adaptive immunity. Elderly caregivers have poorer responses to vaccines, impaired control of latent viruses, exaggerated production of inflammatory mediators and accelerated cellular aging, compared to noncaregiving older adults. The chronic stress-induced immune dysregulation observed among older caregivers appears to be of sufficient magnitude to impact health. Furthermore, evidence suggests that chronic stress leads to premature aging of the immune system.
PKC zeta is a molecular switch in signal transduction of TNF‐alpha, bifunctionally regulated by ceramide and arachidonic acid.

Tumor necrosis factor (TNF‐alpha) stimulates a number of signal transduction pathways in which phospholipases produce lipid second messengers. However, the immediate molecular targets of these messengers, in particular those of ceramide and arachidonic acid (AA) and their role in TNF signaling are not well defined. In this study we investigated the relationship of ceramide and AA in regulating an atypical PKC isozyme, PKC zeta. U937 cells responding to TNF‐alpha treatment with NF kappa B activation displayed enhanced phosphorylation of PKC zeta, which is already detectable 30 s after stimulation. [14C]ceramide specifically binds to and regulates kinase activity of PKC zeta in a biphasic manner. Binding studies indicate high and low affinity binding with bmax values of 60 and 600 nM and Kd values of 7.5 and 320 nM respectively. At ceramide concentrations as low as 0.5 nM an up to 4‐fold increase in autophosphorylation is obtained, which, at concentrations > 60 nM, again declines to basal levels. Interestingly, AA competes for ceramide binding and inhibits basal and ceramide‐stimulated PKC zeta kinase activity at < 100 nM. Metabolism of [14C]ceramide in cells is slow and is inhibited in the presence of equimolar concentrations of lyso‐phosphatidylcholine. Based on the bifunctional modulation of PKC zeta by the lipid messengers ceramide and AA, a model of TNF signal pathways is suggested in which PKC zeta takes a central position, acting as a molecular switch between mitogenic and growth inhibitory signals of TNF‐alpha.
Innovation Activities and Integration through Vertical Acquisitions

We examine the determinants of vertical acquisitions using product text linked to product vocabulary from input-output tables. We find that the innovation stage is important in understanding vertical integration. R&D-intensive firms are less likely to become targets of vertical acquisitions. In contrast, firms with patented innovation are more likely to sell to vertically related buyers. Firms’ R&D intensity is a more important deterrent to their vertical acquisitions when the provision of innovation incentives by potential acquirers is more difficult. The role of patents in fostering vertical acquisitions is more prevalent when potential buyers face a higher risk of holdup. (JEL G32, G34, L22, L25, O34)
Launching and evaluating a mobile phone app to provide contemporary, evidence-based advice about self-treatable conditions

Rationale, aims and objectives: As government-funded healthcare provisions are stretched to their limits, it is important that healthcare professionals provide evidence-based advice about minor ailments to facilitate people’s abilities to self-treat these conditions effectively and appropriately, given that self-care is one of the many components of person-centered healthcare. Unfortunately, despite the expanding over-the-counter (OTC) medicines market, there have been doubts cast about advice given by UK community pharmacists. Indeed, research conducted with pharmacists revealed that evidence of effectiveness was a secondary consideration when making decisions about OTC recommendations. We aimed to address these concerns and support decision-making by providing high quality, evidence-based, information about self-treatable conditions and over-the-counter consultations through a mobile phone app.Method: There were 4 main stages, namely: (1) app development (content and design); (2) piloting (use-testing); (3) publication on Apple and Android stores and marketing of the app and, finally, (4) an evaluation (using analytical data obtained through the app content management system, feedback obtained via email, the star-rating and reviews posted on Google Play and Apple stores and comments obtained at events. Additionally, following ethical approval and piloting, we invited 100 people, representing different groups within the pharmacy profession in Northern Ireland, to complete an evaluation questionnaire.Results: Since launching the project in February 2017, there have been over 5000 downloads, 68,453 sessions of use and the app has received a 5-star rating on both Apple and Google Play stores. Positive feedback has centred on the material being relevant and up-to-date, that it facilitates quick access to information in the workplace and is easy to navigate and that it is a good training tool. Future suggestions for improvement include expanding the number of conditions and providing self-assessment questions to help students prepare for professional examinations.Conclusions: The app appears to have had a positive impact on OTC consultations, but it is still evolving to ensure its usefulness in practice is maximised.
A Chandra X-Ray Study of NGC 1068. II. The Luminous X-Ray Source Population

We present an analysis of the compact X-ray source population in the Seyfert 2 galaxy NGC 1068, imaged with a ~50 ks Chandra observation. We find a total of 84 compact sources on the S3 chip, of which 66 are located within the 25.0 B-mag arcsec-2 isophote of the galactic disk of NGC 1068. Spectra have been obtained for the 21 sources with at least 50 counts and modeled with both multicolor disk blackbody and power-law models. The power-law model provides the better description of the spectrum for 18 of these sources. For fainter sources, the spectral index has been estimated from the hardness ratio. Five sources have 0.4-8 keV intrinsic luminosities greater than 1039 ergs s-1, assuming that their emission is isotropic and that they are associated with NGC 1068. We refer to these sources as intermediate-luminosity X-ray objects (IXOs). If these five sources are X-ray binaries accreting with luminosities that are both sub-Eddington and isotropic, then the implied source masses are ≳7 M☉, and so they are inferred to be black holes. Most of the spectrally modeled sources have spectral shapes similar to Galactic black hole candidates. However, the brightest compact source in NGC 1068 has a spectrum that is much harder than that found in Galactic black hole candidates and other IXOs. The brightest source also shows large amplitude variability on both short-term and long-term timescales, with the count rate possibly decreasing by a factor of 2 in ~2 ks during our Chandra observation, and the source flux decreasing by a factor of 5 between our observation and the grating observations taken just over 9 months later. The ratio of the number of sources with luminosities greater than 2.1 × 1038 ergs s-1 in the 0.4-8 keV band to the rate of massive (>5 M☉) star formation is the same, to within a factor of 2, for NGC 1068, the Antennae, NGC 5194 (the main galaxy in M51), and the Circinus galaxy. This suggests that the rate of production of X-ray binaries per massive star is approximately the same for galaxies with currently active star formation, including "starbursts. "
Re-Creating Waves in Large Currents for Tidal Energy Applications

Unsteady wave loading on tidal turbines impacts significantly the design, and expected life-time, of turbine blades and other key components. Model-scale testing of tidal turbines in the wave-current environment can provide vital understanding by emulating real-world load cases; however, to reduce uncertainty, it is important to isolate laboratory-specific artefacts from real-world behaviour. In this paper, a variety of realistic combined current-wave scenarios is re-created at the FloWave basin, where the main objective is to understand the characteristics of testing in a combined wave-current environment and assess whether wave effects on the flow field can be predicted. Here, we show that a combination of linear wave-current theory and frequency-domain reflection analysis can be used to effectively predict wave-induced particle velocities and identify velocity components that are experimental artefacts. Load-specific mechanisms present in real-world conditions can therefore be isolated, and equivalent full-scale load cases can be estimated with greater confidence. At higher flow speeds, a divergence from the theory presented is observed due to turbulence-induced non-stationarity. The methodology and results presented increase learning about the wave-current testing environment and provide analysis tools able to improve test outputs and conclusions from scale model testing.
Consumer brand engagement and its social side on brand-hosted social media: how do they contribute to brand loyalty?

ABSTRACT Social media offer brands new opportunities to interact with their customers. This paper focuses on consumer brand engagement (CBE) and its social facet in the context of brand-hosted social media. It highlights that CBE (consumer–brand interactions encompassing cognitive, affective and behavioural dimensions) and brand-based consumer–consumer interactions (social brand engagement (SBE)) lead to brand loyalty intentions. Brand customers were surveyed about their favourite brands on Facebook. Results indicate that self-brand connections and SBE are two drivers of CBE, and that CBE is the key element in inducing brand loyalty. In addition, configural analysis shows that high brand loyalty can be achieved through several combinations of social and CBE with various levels of cognitive, affective and behavioural engagement.
Evidence for idiotype-directed immunosurveillance is restricted to follicular lymphoma and attributable to somatic hypermutation

Antigen receptors of B cells (BCR) exhibit a virtually unlimited repertoire, created by V(D)J recombination through combinatorial and junctional diversity of genetic elements in B-precursor cells. B cells further increase the antigen affinity of their BCR through somatic hypermutation (SHM). VDJ
Inhibition of protein synthesis stabilizes histone mRNA

The inhibition of protein synthesis in exponentially growing S49 cells leads to a specific fivefold increase in histone mRNA in 30 min. The rate of transcription of histone mRNA, measured in intact or digitonin-permeabilized cells, is increased slightly, if at all, by cycloheximide inhibition of protein synthesis. Both approach-to-equilibrium labeling and pulse-chase experiments show that cycloheximide prolongs histone mRNA half-life from approximately 30 min to greater than 2 h. Histone mRNA made before the addition of cycloheximide becomes stable after the inhibition of protein synthesis, whereas removal of the inhibitor is followed by rapid degradation of histone mRNA. This suggests that the increased stability of histone mRNA during inhibition of protein synthesis results not from alteration of the structure of the mRNA, but from the loss of an activity in the cell which regulates histone mRNA turnover.
Tratamiento de los carcinomas epidermoides orales y orofaringeos mediante láser de CO2

Introduction: The effect of the wide long-wave CO2 laser is the thermal vaporization of the tissues, getting a maximum energy concentration with a minimum of tissue penetration. In oral surgery, it is generally used for the treatment of oral and oropharyngeal small mucous tumors, due to the scarce morbidity that takes place and the absence of reconstructive necessity. Objective: To analyze the postoperative evolution, in the patients treated by oral and oropharyngeal epidermoid carcinomas, after CO2 laser resection. To compare it with that of the patients treated by means of conventional surgical methods, achieving the reconstruction through direct suture or the employment of local, regional or distance flaps. Methods: A prospective study was designed including 70 patients treated by oral and oropharyngeal epidermoid carcinomas. Thirty-five patients were treated by means of CO2 laser, in 10 cases direct wound-closure was realized, and in the remaining 25 patients some local, regional or distance flap were used. There were analysed the presence of postoperative pain, the degree of cicatricial retraction, and the speech and swallowing functional results. Results: We obtained a smaller painful degree and postoperative cicatricial retraction by the employment of CO2 laser. It permits minimizing the functional speech sequels (better words articulation) and swallowing (effective and precocious functional recovery). Conclusion: CO2 laser resection has become the elective treatment for small oral and oropharyngeal epidermoid carcinomas. The reasons are the absence of reconstructive surgery necessity, the scarce cicatricial retraction, and the excellent postoperative evolution.
Changes in Grape Maturity Induced by Spraying Ethanol

Three different ethanol solutions were sprayed onto Cabernet Sauvignon (Vitis vinifera L.) clusters during the ripening period: 2.5, 5 and 10% by volume in water. Controls were sprayed with water alone. Three different times of spraying were also tested: 8, 10 and 13 weeks post-flowering. One of the observed changes was a lower titratable acidity in grape samples at harvest, when the clusters were sprayed with ethanol at 10 weeks, in comparison with controls. The wines made with grapes treated with ethanol after mid-veraison, had higher ODs at 520 nm than did the controls. This may due to a combined effect of red pigment levels and acidity. In addition, following malolactic fermentation, the acidity levels of wines made with ethanoltreated grapes were slightly higher than those made with the control grapes. Spraying ethanol at 13 weeks post-flowering increased the berry weight by 10% at harvest without decreasing the °Brix value. The corresponding wines had similar degrees of alcohol. This observation was made for the first time in 2001.
GIV/Girdin (Gα-interacting, Vesicle-associated Protein/Girdin) Creates a Positive Feedback Loop That Potentiates Outside-in Integrin Signaling in Cancer Cells*

Activation of the tyrosine kinase focal adhesion kinase (FAK) upon cell stimulation by the extracellular matrix initiates integrin outside-in signaling. FAK is directly recruited to active integrins, which enhances its kinase activity and triggers downstream signaling like activation of PI3K. We recently described that Gα-interacting, vesicle-associated protein (GIV), a protein up-regulated in metastatic cancers, is also required for outside-in integrin signaling. More specifically, we found that GIV is a non-receptor guanine nucleotide exchange factor that activates trimeric G proteins in response to integrin stimulation to enhance PI3K signaling and tumor cell migration. In contrast, previous reports have established that GIV is involved in phosphotyrosine (Tyr(P))-based signaling in response to growth factor stimulation; i.e. GIV phosphorylation at Tyr-1764 and Tyr-1798 recruits and activates PI3K. Here we show that phosphorylation of GIV at Tyr-1764/Tyr-1798 is also required to enhance PI3K-Akt signaling and tumor cell migration in response to integrin stimulation, indicating that GIV functions in Tyr(P)-dependent integrin signaling. Unexpectedly, we found that activation of FAK, an upstream component of the integrin Tyr(P) signaling cascade, was diminished in GIV-depleted cells, suggesting that GIV is required to establish a positive feedback loop that enhances integrin-FAK signaling. Mechanistically, we demonstrate that this feedback activation of FAK depends on both guanine nucleotide exchange factor and Tyr(P) GIV signaling as well as on their convergence point, PI3K. Taken together, our results provide novel mechanistic insights into how GIV promotes proinvasive cancer cell behavior by working as a signal-amplifying platform at the crossroads of trimeric G protein and Tyr(P) signaling.
Novel Polymorphism at Exon 2 of Caprine MHC Class II DRB3 Gene in Marwari Goats

The highly polymorphic genes of the MHC play a major role in the immune recognition of pathogens and parasites. The purpose of this study was to study the polymorphism of CLA-DRB3 (Caprine Leukocyte Antigenantigen D Related β3-chain) gene in Marwari goat using PCR-RFLP technique. A region of exon 2 encompassing 285 bp fragment of DRB 3.2 gene in Marwari goats was amplified by polymerase chain reaction (PCR). The restriction digestion by Hin1I revealed two alleles, A and G with frequencies 0.452 and 0.548, respectively and three genotypes, AA (285 bp), AG (285/174/111 bp) and GG (174/111 bp) with frequencies 0.242, 0.420 and 0.338, respectively. The polymorphic information content (PIC) value and expected heterozygosity were 0.373 and 0.495, respectively which were high in both cases. The present study shows polymorphic nature of MHC Class II DRB3 gene at this locus in Marwari goats.