Miracle-dz/UniFAR-FTUs huggingface dataset:
Volatility and lifetime against OH heterogeneous reaction of ambient isoprene-epoxydiols-derived secondary organic aerosol (IEPOX-SOA)

Abstract. Isoprene-epoxydiols-derived secondary organic aerosol (IEPOX-SOA) can contribute substantially to organic aerosol (OA) concentrations in forested areas under low NO conditions, hence significantly influencing the regional and global OA budgets, accounting, for example, for 16–36 % of the submicron OA in the southeastern United States (SE US) summer. Particle evaporation measurements from a thermodenuder show that the volatility of ambient IEPOX-SOA is lower than that of bulk OA and also much lower than that of known monomer IEPOX-SOA tracer species, indicating that IEPOX-SOA likely exists mostly as oligomers in the aerosol phase. The OH aging process of ambient IEPOX-SOA was investigated with an oxidation flow reactor (OFR). New IEPOX-SOA formation in the reactor was negligible, as the OFR does not accelerate processes such as aerosol uptake and reactions that do not scale with OH. Simulation results indicate that adding ∼ 100 µg m−3 of pure H2SO4 to the ambient air allows IEPOX-SOA to be efficiently formed in the reactor. The heterogeneous reaction rate coefficient of ambient IEPOX-SOA with OH radical (kOH) was estimated as 4.0 ± 2.0 × 10−13 cm3 molec−1 s−1, which is equivalent to more than a 2-week lifetime. A similar kOH was found for measurements of OH oxidation of ambient Amazon forest air in an OFR. At higher OH exposures in the reactor (> 1 × 1012 molec cm−3 s), the mass loss of IEPOX-SOA due to heterogeneous reaction was mainly due to revolatilization of fragmented reaction products. We report, for the first time, OH reactive uptake coefficients (γOH = 0.59 ± 0.33 in SE US and γOH = 0.68 ± 0.38 in Amazon) for SOA under ambient conditions. A relative humidity dependence of kOH and γOH was observed, consistent with surface-area-limited OH uptake. No decrease of kOH was observed as OH concentrations increased. These observations of physicochemical properties of IEPOX-SOA can help to constrain OA impact on air quality and climate.
Moyamoya disease: a review of histopathology, biochemistry, and genetics.

OBJECT Moyamoya disease (MMD) is a rare cerebrovascular disorder involving stenosis of the major vessels of the circle of Willis and proximal portions of its principal branches. Despite concerted investigation, the pathophysiology of the disorder has not been fully elucidated. Currently, the major proteins believed to play an active role in the pathogenesis include vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), hepatocyte growth factor (HGF), transforming growth factor-β₁ (TGFβ₁), and granulocyte colony-stimulating factor (G-CSF). In terms of the genetics, recent literature suggests a low penetrance autosomal dominant or polygenic mode of transmission involving chromosomes 3, 6, 8, 12, and 17 for familial MMD. This review summarizes the current knowledge on the histopathology, pathophysiology and genetics of MMD. METHODS A PubMed/Medline systematic study of the literature was performed, from which 45 articles regarding MMD pathophysiology were identified and analyzed. CONCLUSIONS Moyamoya disease is characterized by the intimal thickening and media attenuation of the proximal vessels of the circle of Willis as well as the development of an aberrant distal vascular network. The primary proteins that are currently implicated in the pathophysiology of MMD include VEGF, bFGF, HGF, TGFβ₁, and G-CSF. Furthermore, the current literature on familial MMD has pointed to a low penetrance autosomal dominant or polygenic mode of transmittance at loci on chromosomes 3, 6, 8, 12, and 17.
The effectiveness of Tai Chi for chronic musculoskeletal pain conditions: a systematic review and meta-analysis.

OBJECTIVE To determine whether Tai Chi improves pain, disability, physical performance, and/or health-related quality of life (HRQOL) in people with chronic musculoskeletal pain. METHODS Eight databases were searched for randomized controlled trials (RCTs). Two independent reviewers rated trial quality and extracted trial data. Effect sizes and 95% confidence intervals were calculated for individual trials, and pooled effect sizes were calculated using a random-effects model. RESULTS Seven RCTs were selected for inclusion in the review. Of these, 6 studied people with chronic arthritis and 1 studied people with chronic tension headaches. The trials were typically small and of low methodologic quality. The pooled effect size for arthritic populations on a 0-100 scale was 10.1 (range 6.3-13.9) points for pain reduction, and was 9.6 (range 5.2-14.0) points for disability reduction. Additionally, physical performance and HRQOL outcomes favored the Tai Chi intervention, but of these outcomes, only the level of tension and satisfaction with general health were statistically significant. CONCLUSION The available data on the effect of Tai Chi are sparse and derived principally from low-quality studies. These data suggest that Tai Chi has a small positive effect on pain and disability in people with arthritis. The extent to which it benefits other forms of musculoskeletal pain is unclear.
Health benefits of air pollution abatement policy: Role of the shape of the concentration–response function

There is strong evidence that fine particulate matter (aerodynamic diameter <2.5 μm; PM2.5) air pollution contributes to increased risk of disease and death. Estimates of the burden of disease attributable to PM2.5 pollution and benefits of reducing pollution are dependent upon the shape of the concentration response (C-R) functions. Recent evidence suggests that the C-R function between PM2.5 air pollution and mortality risk may be supralinear across wide ranges of exposure. Such results imply that incremental pollution abatement efforts may yield greater benefits in relatively clean areas than in highly polluted areas. The role of the shape of the C-R function in evaluating and understanding the costs and health benefits of air pollution abatement policy is explored. There remain uncertainties regarding the shape of the C-R function, and additional efforts to more fully understand the C-R relationships between PM2.5 and adverse health effects are needed to allow for more informed and effective air pollution abatement policies. Current evidence, however, suggests that there are benefits both from reducing air pollution in the more polluted areas and from continuing to reduce air pollution in cleaner areas. Implications: Estimates of the benefits of reducing PM2.5 air pollution are highly dependent upon the shape of the PM2.5-mortality concentration-response (C-R) function. Recent evidence indicates that this C-R function may be supralinear across wide ranges of exposure, suggesting that incremental pollution abatement efforts may yield greater benefits in relatively clean areas than in highly polluted areas. This paper explores the role of the shape of the C-R function in evaluating and understanding the costs and health benefits of PM2.5 air pollution abatement.
The Determinant of Accounting Conservatism on Manufacturing Companies in Indonesia

Tujuan penelitian ini adalah untuk mengetahui dan menganalisis pengaruh financial distress, leverage, investment opportunity set (IOS), dan kepemilikan manajerial terhadap konservatisme akuntansi. Populasi peneltian adalah perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia (BEI) pada tahun 2013-2016 sebanyak 143 perusahaan. Teknik pengambilan sampel menggunakan purposive sampling sehingga menghasilkan 20 sampel dan 80 unit analisis. Alat analisis data yang digunakan yaitu analisis regresi linear berganda dengan menggunakan Program IBM SPSS 23. Hasil penelitian menunjukkan bahwa financial distress dan leverage berpengaruh positif secara signifikan terhadap konservatisme akuntansi. Namun, investment opportunity set (IOS) tidak berpengaruh terhadap konservatisme akuntansi. Sedangkan kepemilikan manajerial berpengaruh negatif secara signifikan terhadap konservatisme akuntansi. Berdasarkan hasil penelitian, dapat disimpulkan bahwa financial distress dan leverage dapat meningkatkan penerapan konservatisme akuntansi. Sedangkan kepemilikan manajerial dapat menurunkan penerapan konservatisme akuntansi.
Chromosomal aberrations in a series of large-cell neuroendocrine carcinomas: unexpected divergence from small-cell carcinoma of the lung.

Large-cell neuroendocrine carcinoma (LCNEC) and small-cell lung cancer (SCLC) are high-grade neuroendocrine tumors of the lung. Despite different morphologic appearances, loss of heterozygosity and oncogene studies on LCNEC to date suggest genetic similarities. We analyzed 13 LCNEC and 5 mixed SCLC/LCNEC tumors by comparative genomic hybridization and subsequently compared our results with previously published data on 32 SCLCs. Comparison with SCLC showed several shared chromosomal aberrations, specifically losses of 3p, 4q, 5q, and 13q and gains of 5p. However, these aberrations are no special feature of neuroendocrine lung tumors but can also be found in other high-grade lung carcinomas. From this point of view, genetic similarities of LCNEC and SCLC are less important than the nonrandom changes that differ between these 2 tumor types. A gain of 3q observed in 66% of all SCLCs was detected only once in the LCNEC group. In contrast to the pure LCNEC, all mixed types with a SCLC component had a gain of 3q. Gains of 6p occurred more frequently in LCNEC. Deletions of 10q, 16q, and 17p were less frequent in LCNEC than in SCLC.
The Prevalence of Ataques De Nervios in the Puerto Rico Disaster Study: The Role of Culture in Psychiatric Epidemiology

This paper presents one of the few epidemiological studies of a popular category of distress, ataques de nervios (attacks of nerves), in the cross-cultural psychiatric literature. As part of a major study of the psychological consequences of the 1985 floods and mudslides which caused considerable damage and death in Puerto Rico, a question was added to the Diagnostic Interview Schedule/Disaster Supplement concerning ataques de nervios. This additional item provided the opportunity to carry out the first study of this important Puerto Rican popular category of distress using a representative, community-based sample. This paper addresses several key questions about ataques de nervios which come from previous psychiatric and anthropological literatures concering the social correlates of who experiences an ataque de nervios and the relationship of ataques to social distress and psychiatric disorder. People who reported an ataque de nervios were more likely to be female, older, less educated, and formerly married. They were also more likely to meet criteria for anxiety and depressive disorders than those who had not experienced an ataque. The picture that emerges from our analyses is that those who suffer from a combination of social disadvantage, psychiatric disorder, and poor perceived health are more likely to experience an ataque de nervios.
System identification and closed-loop control of end-tidal CO2 partial pressure in mechanically ventilated patients

This paper presents a systematic approach to system identification and closed-loop control of end-tidal carbon dioxide partial pressure (P<inf>ET</inf>CO<inf>2</inf>) in mechanically ventilated patients. An empirical model consisting of a linear dynamic system followed by an affine transform is proposed to derive a low-order and high-fidelity representation that can reproduce the positive and inversely proportional dynamic input-output relationship between P<inf>ET</inf>CO<inf>2</inf> and minute ventilation (MV) in mechanically ventilated patients. The predictive capacity of the empirical model was evaluated using experimental respiratory data collected from eighteen mechanically ventilated human subjects. The model predicted P<inf>ET</inf>CO<inf>2</inf> response accurately with a root-mean-squared error (RMSE) of 0.22+/−0.16mmHg and a coefficient of determination (r<sup>2</sup>) of 0.81+/−0.18 (mean+/− SD) when a second-order rational transfer function was used as its linear dynamic component. Using the proposed model, a closed-loop control method for P<inf>ET</inf>CO<inf>2</inf> based on the proportional-integral (PI) compensator was proposed by the systematic analysis of the system root locus. For the eighteen mechanically ventilated patient models identified, the PI compensator exhibited acceptable closed-loop response with a settling time of 1.27+/−0.20min and a negligible overshoot (0.51+/−1.17%), in addition to zero steady-state P<inf>ET</inf>CO<inf>2</inf> set point tracking.
Mutations in beta-myosin S2 that cause familial hypertrophic cardiomyopathy (FHC) abolish the interaction with the regulatory domain of myosin-binding protein-C.

The myosin filaments of striated muscle contain a family of enigmatic myosin-binding proteins (MyBP), MyBP-C and MyBP-H. These modular proteins of the intracellular immunoglobulin superfamily contain unique domains near their N termini. The N-terminal domain of cardiac MyBP-C, the MyBP-C motif, contains additional phosphorylation sites and may regulate contraction in a phosphorylation dependent way. In contrast to the C terminus, which binds to the light meromyosin portion of the myosin rod, the interactions of this domain are unknown. We demonstrate that fragments of MyBP-C containing the MyBP-C motif localise to the sarcomeric A-band in cardiomyocytes and isolated myofibrils, without affecting sarcomere structure. The binding site for the MyBP-C motif resides in the N-terminal 126 residues of the S2 segment of the myosin rod. In this region, several mutations in beta-myosin are associated with FHC; however, their molecular implications remained unclear. We show that two representative FHC mutations in beta-myosin S2, R870H and E924K, drastically reduce MyBP-C binding (Kd approximately 60 microM for R870H compared with a Kd of approximately 5 microM for the wild-type) down to undetectable levels (E924K). These mutations do not affect the coiled-coil structure of myosin. We suggest that the regulatory function of MyBP-C is mediated by the interaction with S2, and that mutations in beta-myosin S2 may act by altering the interactions with MyBP-C.
Caffeine Eliminates Gamma-Ray-Induced G2-Phase Delay in Human Tumor Cells but Not in Normal Cells

Abstract Jha, M. N. , Bamburg, J. R. , Bernstein, B. W. and Bedford, J. S. Caffeine Eliminates Gamma-Ray-Induced G2-Phase Delay in Human Tumor Cells but Not in Normal Cells. Radiat. Res. 157, 26–31 (2002). It has been known for many years that caffeine reduces or eliminates the G2-phase cell cycle delay normally seen in human HeLa cells or Chinese hamster ovary (CHO) cells after exposure to X or γ rays. In light of our recent demonstration of a consistent difference between human normal and tumor cells in a G2-phase checkpoint response in the presence of microtubule-active drugs, we examined the effect of caffeine on the G2-phase delays after exposure to γ rays for cells of three human normal cell lines (GM2149, GM4626, AG1522) and three human tumor cell lines (HeLa, MCF7, OVGI). The G2-phase delays after a dose of 1 Gy were similar for all six cell lines. In agreement with the above-mentioned reports for HeLa and CHO cells, we also observed that the G2-phase delays were eliminated by caffeine in the tumor cell lines. In sharp contrast, caffeine did not eliminate or even reduce the γ-ray-induced G2-phase delays in any of the human normal cell lines. Since caffeine has several effects in cells, including the inhibition of cAMP and cGMP phosphodiesterases, as well as causing a release of Ca++ from intracellular stores, we evaluated the effects of other drugs affecting these processes on radiation-induced G2-phase delays in the tumor cell lines. Drugs that inhibit cAMP or cGMP phosphodiesterases did not eliminate the radiation-induced G2-phase delay either separately or in combination. The ability of caffeine to eliminate radiation-induced G2-phase delay was, however, partially reduced by ryanodine and eliminated by thapsigargin, both of which can modulate intracellular calcium, but by different mechanisms. To determine if caffeine was acting through the release of calcium from intracellular stores, calcium was monitored in living cells using a fluorescent calcium indicator, furaII, before and after the addition of caffeine. No calcium release was seen after the addition of caffeine in either OVGI tumor cells or GM2149 normal cells, even though a large calcium release was measured in parallel experiments with ciliary neurons. Thus it is likely that caffeine is eliminating the radiation-induced G2-phase delay through a Ca++-independent mechanism, such as the inhibition of a cell cycle-regulating kinase.
LH responses to single doses of exogenous GnRH by social Mashona mole–rats:a continuum of socially induced infertility in the family Bathyergidae

The Mashona mole‐rat, Cryptomys darlingi exhibits an extreme reproductive division of labour. Reproduction in the colony is restricted to a single breeding pair. The non–reproductive male and female colony members are restrained from sexual activity by being familiar and related to one another and the reproductive animals. Circulating basal concentrations of luteinizing hormone (LH) as well as LH levels measured in response to a single exogenous gonadotropin releasing hormone (GnRH) challenge are not significantly different between the reproductive and non–reproductive groups of either sex. Socially induced infertility in both non–reproductive males and females does not result from a reduced pituitary secretion of LH or decreased sensitivity to hypothalamic GnRH, but rather appears to result from an inhibition of reproductive behaviour in these obligate outbreeders. The African mole–rats exhibit a continuum of socially induced infertility with differing social species inhabiting regions of varying degrees of aridity. In this continuum a transition from a predominantly behavioural repression in a social mesic–adapted species through to complete physiological suppression lacking incest avoidance in an arid–adapted eusocial species occurs in this endemic African family of rodents.
Releasing Phosphorus from Calcium for Struvite Fertilizer Production from Anaerobically Digested Dairy Effluent

Being a non‐renewable resource and a source of potential water pollution, phosphorus could be recovered from animal manure in the form of struvite (MgNH4PO4·6H2O) to be used as a slow‐release fertilizer. It was found recently that the majority of phosphorus in anaerobically digested dairy effluent is tied up in a fine suspended calcium‐phosphate solid, thus becoming unavailable for struvite formation. Acidification and use of a chelating agent were investigated for converting the calcium‐associated phosphorus in the digested effluent to dissolved phosphate ions, so that struvite can be produced. The results demonstrated that the phosphorus in the effluent was released into the solution by lowering the pH. In addition, the phosphorus concentration in the solution increased significantly with increased ethylenediaminetetraacetic acid (EDTA) concentration, as EDTA has a high stability constant with calcium. Most of the phosphorus (91%) was released into the solution after adding EDTA. Further, the freed phosphorus ion precipitated out as struvite provided that sufficient magnesium ions (Mg2+) were present in the solution. Furthermore, the phase structure of the solid precipitate obtained from the EDTA treatment matched well with standard struvite, based on the data from X‐ray diffraction analysis. These results provide methods for altering the forms of phosphorus for the design and application of phosphorus‐removal technologies for dairy wastewater management.
Functional and morphologic changes caused by acute ozone exposure in the isolated and perfused rat lung.

Ozone has been shown to increase airway resistance and/or airway reactivity in vivo in animals and humans. Because of the complexities inherent in studying this phenomenon in whole animals, we developed a model of ozone-induced effects on airway physiology using the isolated perfused rat lung. Rat lungs were suspended in an airtight chamber and perfused via the pulmonary circulation with a modified Krebs-Henseleit buffer containing 4.5% bovine albumin. Ventilation of the lungs was achieved by generating a fluctuating negative pressure within the chamber (-2 to -7 cm H2O) at a rate of 60 breaths/min. The lungs were ventilated with humidified 95% air and 5% CO2 alone (control condition) or mixed with ozone at 1.0 or 2.0 ppm. Transpulmonary pressure, flow rate, and tidal volume were recorded at 0, 1, 2, and 3 hours, and pulmonary resistance (RL) and dynamic compliance (Cdyn) were calculated. There was no significant difference in lung weight/total body weight ratios between the three groups at the end of the 3-h period. RL increased and Cdyn decreased in a time- and dose-dependent manner with ozone exposure. The percent increase above baseline in RL +/- SEM at 3 h was 9.4 +/- 4.1% for control lungs, 21.0 +/- 3.2% for 1.0 ppm ozone-exposed lungs, and 63.6 +/- 13.5% for 2.0 ppm ozone-exposed lungs. The percent decrease below baseline in Cdyn +/- SEM at 3 h was 27.4 +/- 2.1% for control lungs, 37.1 +/- 2.7% for 1.0 ppm ozone-exposed lungs, and 55.2 +/- 7.3% for 2.0 ppm ozone-exposed lungs. (ABSTRACT TRUNCATED AT 250 WORDS)
Women in politics in Kenya: an analysis of participation and barriers

Women constitute more than half of the world’s population but their representation in the political arena has consistently been lower compared to men. Since representation is important in the allocation of resources, laws have been passed to guarantee gender parity in decision-making. In Kenya, the 2010 Constitution introduced a two-third gender rule to enhance parity in legislative bodies at both lower and national legislative bodies. From a sociological perspective, this paper assessed the extent of participation of women in the political development of Kenya. The qualitative study used interviews to analyse the contribution of women in politics. In all, 30 key informants, made up of 11 males and 19 females, were purposively recruited for the study. The study found that there were hindrances to women’s effective political participation which included; political environment characterized by violence propaganda, discrimination based on gender and lack of support from fellow women. The study and its implication for policymaking has been discussed extensively.
Sons of the Shaking Earth

"Wolf drew on anthropology, archaeology, history, and geography to mold a magnificent, sweeping, and beautifully written synthesis. With style and deep personal engagement he unraveled the complexity of Mexico and Guatemala's past with its multiple ethnicities, many languages, and environmental diversity. Armies of graduate students have challenged many of the details, but the book stands as a monument to a time when social scientists were able to think large thoughts and write elegant English"-- "Foreign Affairs," Significant Books of the Last 75 Years.