Miracle-dz/UniFAR-FTUs huggingface dataset:
A Study on Mastectomy Samples to Evaluate Breast Imaging Quality and Potential Clinical Relevance of Differential Phase Contrast Mammography

ObjectivesDifferential phase contrast and scattering-based x-ray mammography has the potential to provide additional and complementary clinically relevant information compared with absorption-based mammography. The purpose of our study was to provide a first statistical evaluation of the imaging capabilities of the new technique compared with digital absorption mammography. Materials and MethodsWe investigated non-fixed mastectomy samples of 33 patients with invasive breast cancer, using grating-based differential phase contrast mammography (mammoDPC) with a conventional, low-brilliance x-ray tube. We simultaneously recorded absorption, differential phase contrast, and small-angle scattering signals that were combined into novel high-frequency-enhanced images with a dedicated image fusion algorithm. Six international, expert breast radiologists evaluated clinical digital and experimental mammograms in a 2-part blinded, prospective independent reader study. The results were statistically analyzed in terms of image quality and clinical relevance. ResultsThe results of the comparison of mammoDPC with clinical digital mammography revealed the general quality of the images to be significantly superior (P < 0.001); sharpness, lesion delineation, as well as the general visibility of calcifications to be significantly more assessable (P < 0.001); and delineation of anatomic components of the specimens (surface structures) to be significantly sharper (P < 0.001). Spiculations were significantly better identified, and the overall clinically relevant information provided by mammoDPC was judged to be superior (P < 0.001). ConclusionsOur results demonstrate that complementary information provided by phase and scattering enhanced mammograms obtained with the mammoDPC approach deliver images of generally superior quality. This technique has the potential to improve radiological breast diagnostics.
Determining the potential and requirements of transit-oriented development (TOD): The case of Malaysia

Purpose The purpose of this paper is to explore the potential of transit-oriented development (TOD), the perceptions of buyers and the establishment of the comfortable walking distance. The literature indicates the requirement of TOD with increasing population in major cities. Design/methodology/approach In this study, exploratory sequential mixed methods research approach was adopted. Semi-structured interviews were conducted followed by questionnaire survey. The respondents were categorised based on their generation cohorts to further understand their acuities on TOD. Findings The key consideration factors when buying houses in the TOD area are as follows: amenities related to jobs and family for Baby Boomers; time saving for Generation Y; and location for Generation X, i.e. house should be conveniently located in relation to working place, school, etc. Communities in Malaysia are willing to walk for five to ten minutes (approximately 400 to 800 m). Research limitations/implications Future studies can be enlarged to include other major cities in Malaysia and draw comparisons with neighbouring ASEAN countries. Practical implications This paper provides insights to property developers, consultants and government agencies for product development. Ultimately, TOD is the innovative sustainable solution for high-density urban planning and development. Social implications TOD is a sustainable development concept that encourages the use of public transportation system in order to reduce private motor vehicles usage. Originality/value This paper emphasises the potential of TOD, explores the perceptions of different generation cohorts in relation to TOD and establishes the comfortable walking distance for Malaysian communities. It also highlights the key factors of conveniences for TOD.
Multitarget fluorescence in situ hybridization assay detects transitional cell carcinoma in the majority of patients with bladder cancer and atypical or negative urine cytology.

PURPOSE The multitarget fluorescence in situ hybridization (FISH) probe set UroVysion (Vysis, Downers Grove, Illinois), containing probes to chromosomes 3, 7 and 17, and to the 9p21 band, has been recently shown to have high sensitivity and specificity for detecting transitional cell carcinoma. In this study we retrospectively tested 120 urine samples from patients with atypical, suspicious and negative cytology for whom concurrent and followup bladder biopsy data were available. We evaluated the ability of FISH to identify malignant cells in cytologically equivocal or negative cases. MATERIALS AND METHODS Archived slides from 120 voided (47) or instrumented (73) urine cytology specimens from patients with concurrent bladder biopsy and a minimum of 12 months of biopsy followup were subjected to hybridization with UroVysion. The cohort included patients with biopsy proven transitional cell carcinoma, which was grades 1 to 3 in 23, 35 and 24, respectively, and stages pTis in 3, pTa in 64, pT1 in 6, pT2 in 6 and pT4 in 3, while it showed negative histology in 38. Cytology findings were suspicious, atypical and negative for transitional cell carcinoma in 31, 49 and 40 cases, respectively. A positive FISH result was defined as 5 transitional cells or greater with a gain of 2 or more of chromosomes 3, 7 or 17, 12 cells or greater with 9p21 deletion, or 10% or greater of cells with isolated trisomy of 1 of chromosomes 3, 7 and 17. RESULTS All except 12 of the 82 biopsy proven transitional cell carcinoma cases (11 pTa and 1 pT1 tumors) were positive by FISH (85% sensitivity). Sensitivity in patients with suspicious, atypical and negative cytology was 100%, 89% and 60%, respectively. Nine patients with atypical cytology had positive FISH in the setting of a negative concurrent bladder biopsy. However, 8 of these 9 patients (89%) had biopsy proven transitional cell carcinoma within 12 months following the date when the sample tested by FISH was obtained. The last of these patients with false-positive results had previously documented pTis disease, which was also present in the next bladder biopsy 15 months following the positive FISH result. The remaining 29 specimens from patients with negative biopsy and a negative 12-month followup tested negative by FISH (97% overall specificity). CONCLUSIONS The UroVysion FISH assay provides high sensitivity and specificity to detect transitional cell carcinoma in cytologically equivocal and negative urine samples. These results emphasize the important role of this assay in the management of bladder cancer.
Myocardial sarcoidosis. Clinical value of technetium-99m sestamibi tomoscintigraphy.

STUDY OBJECTIVE The presence of defects on rest thallium 201 myocardial scintigraphy, reversible after dipyridamole infusion, was already demonstrated in myocardial localization of sarcoidosis. The present study compared the respective efficiency of a new tracer of myocardial blood flow, 99mTc sestamibi (sestamibi), vs thallium 201 (TI) for the diagnosis and follow-up of myocardial sarcoidosis. METHODS Quantitative single photon emission computed tomography (SPECT) was performed in 37 consecutive patients with confirmed sarcoidosis and clinical suspicion of myocardial localization. Three successive scans were performed in all patients within the same day: rest TI SPECT, rest sestamibi SPECT, and dipyridamole sestamibi SPECT. Thirteen patients were reinvestigated after 3 months of corticosteroid therapy. The size and intensity of the defects were compared using a computerized quantitative analysis of bull's eye. RESULTS At rest, sestamibi SPECT is more sensitive than TI, demonstrating significantly larger defects (28.1 +/- 13.2% vs 17.2 +/- 12.8% of bull's eye area, p < 0.001) and detecting abnormalities in seven more patients (24 vs 17). All patients with abnormal TI scans also had sestamibi abnormalities. After dipyridamole infusion, sestamibi defects decreased significantly (28.1 +/- 13.2% vs 15.2 +/- 12.3%, p < 0.001). This improvement correlated with the evolution of sestamibi SPECT performed in the 13 patients reinvestigated after corticosteroid therapy (r = 0.85, p < 0.001). CONCLUSIONS We conclude that sestamibi SPECT is suitable for the diagnosis of myocardial sarcoidosis and represents an objective tool for the follow-up. The improvement after vasodilatation supports the hypothesis of reversible abnormalities in most of these patients and accurately predicts corticosteroid efficiency.
Effects of droperidol on the vasoconstriction produced by noradrenaline, histamine, sympathetic nerve stimulation and potassium ions in the isolated rabbit auricular artery.

Droperidol consistently blocked the vasoconstriction induced by noradrenaline, histamine and sympathetic nerve stimulation in concentrations between 0.01 and 10 μg/ml in the isolated rabbit auricular artery preparation. Vasoconstriction induced by potassium ions was blocked in all concentrations of droperidol but less at the highest concentration. It is postulated, therefore that droperidol is a non-specific inhibitor of vasoconstriction rather than a competitive alpha-adrenergic receptor blocking agent.
[Prenatal screening of kidney pelvis ectasia, frequently caused by vesico-ureteral reflux detected after birth. Analysis of a series of 159 cases in 4 years at a maternal-child unit].

UNLABELLED To describe the pre- and post-natal management of vesico-ureteric reflux in a prospective study of babies presenting with vesico-ureteric reflux suspected from pre-natal ultrasonography in a tertiary paediatric center. PATIENTS AND METHODS Between 1997 and 2001, 35 children (25 boys and 10 girls) with were vesico-ureteric reflux followed for 12 to 36 months after the pre-natal detection of urinary tract anomalies. Ultrasound examination was realized at the 5th of life, retrograde cystography at the 15th if the renal pelvic dilatation measured at least 10 mm of diameter. In 11 the reflux was bilateral and 46 refluxing units were reviewed. RESULTS According to the international classification of, 7% vesico-ureteric reflux were grade I, 20.5% were grade II, 32% were grade III, 18% were grade IV, 22.5% were grade V. Fourteen patients (17 refluxing units) underwent ureteric-reimplantation. Four total and two partial nephrectomics were carried out in patients < 2 years old; in 8 patients the VUR resolved spontaneously. Of the latter, 7 patients (ten refluxing grade III-IV units) are still being followed and awaiting a decision on treatment. CONCLUSION This study confirms the predominance of boys in those with antenatally suspected vesico-ureteric reflux. The spontaneous resolution or improvement during the first 3 years of life was apparent in most cases, even in those with severe reflux (grade III-V).
Towards an empirical research agenda for public value theory

ABSTRACT There is considerable scholarly writing about the theory and application of public value concepts, but this article explores why there is, by contrast, so little empirical research on public value. The article then goes on to provide a framework and a research agenda for inspiring and guiding new empirical research, based on three different conceptualizations of public value, with researchers needing to be explicit about which approach they are using in order to avoid confusion. While case studies have been used as a research method, the authors suggest a much wider array of potential research methods (depending on the research question) covering both quantitative and qualitative approaches and with a wider variety of designs, including comparative analysis. It is suggested that empirical research is undertaken with a more diverse range of stakeholders of public value, breaking out of the public manager-centric approach. This is an exciting agenda for research, though the paper warns that public value may fade from view unless empirical research is undertaken to test, challenge and extend the scholarly contributions.
The Mexican migration to the United States and substance use in northern Mexico.

AIMS To examine the impact of migration to the United States on substance use and substance use disorders in three urban areas of northern Mexico. DESIGN Cross-sectional survey of immigration-related experiences and life-time and past-year alcohol and drug use, in a representative sample of respondents aged 12-65 years. SETTING Interviews were conducted in the cities of Tijuana, Ciudad Juarez and Monterrey during 2005. Respondents were classified into three groups: (i) 'return migrants', (ii) 'relatives of migrants' and (iii) 'others in the general population'. FINDINGS A total of 1630 completed interviews were obtained for a response rate of 70.5%. 'Return migrants' were more likely to have used alcohol, marijuana or cocaine at least once in their life-time and in the last 12 months, more likely to develop a substance use disorder and more likely to have a 12-month substance use disorder compared with 'others in the general population'. Among 'return migrants', longer length of time in the United States and type of work performed as an immigrant were related to higher prevalence of substance use. Among 'relatives of migrants', migration experiences were not associated with increased prevalence of substance use compared with 'others in the general population'. CONCLUSION This study found a link between migration to the United States and the transformation of substance use norms and pathology in Mexico. Future research on pre-migration involvement in substance use and data on the timing of events among return migrants is needed. Public health measures are likely to require cross-border coordination of research and service development.
How making for a purpose in mathematics can provoke mathematical meaning making

In this paper we are concerned to understand the connection that can occur for primary school children between relevant practical, "hands-on" engagement with the material world in partnership with others and the development of mathematical commitment, enthusiasm and understanding. We draw on our personal experiences of a European Union (EU) project, Mathematics in the Making (MiMa)(http://www.mathematicsinthemaking.eu), (Project no. 539872-LLP-1-2013-1-ITCOMENIUS–CMP)funded through the Comenius Lifelong Learning Programme, which was based on a primary school mathematics intervention in five EU countries - England, Germany, Hungary, Italy and Portugal. We use the writings of David Jardine and Peter Applebaum to aid our thinking. We point to how absorbing, extended practical work recognises our humanity and can provide purposeful spaces for meaning-making in mathematics.
The Neuroprotective Effects of Reg‐2 Following Spinal Cord Transection Injury

This study was designed to elucidate the potential neuroprotective effects of Reg‐2 (regeneration gene protein 2) in a rodent model of spinal cord transection injury at the ninth thoracic level. Reg‐2 at 100 and 500 μg, recombinant rat ciliary neurotrophic factor, or vehicle were delivered intrathecally using Alzet miniosmotic pumps. We found that Reg‐2 treatment significantly reduced neuronal death in the spinal cord. There was also an attenuation of inflammation at the injury site and an increase in white matter sparing and retained myelination. Retrograde tracing revealed that Reg‐2 protected axons of long descending pathways at 6 weeks post‐SCI, and the number of FluoroGold‐labeled neurons in spinal and supraspinal regions was also significantly increased. Immunofluorescent staining confirmed that the spared white matter contained neurofilament‐positive axons. Moreover, behavioral improvements were revealed by Basso Beattie Bresnahan locomotor rating scores and grid‐walk analysis. These results suggest that Reg‐2 might promote functional recovery by increasing axonal growth, inhibiting neuronal apoptosis, and attenuating spinal cord secondary injury after SCI. Anat Rec, 2010. © 2010 Wiley‐Liss, Inc.
Initial reactions to tobacco and cannabis smoking: a twin study.

BACKGROUND AND AIMS Initial subjective reactions to cannabis and tobacco, broadly classified as positive or negative, have previously been explored for their associations with onset and maintenance of subsequent abuse/dependence. We examine (i) the factorial architecture of self-reported initial reactions to cannabis and tobacco; (ii) whether these factors associate with concurrently reported age at onset of DSM-IV diagnosis of nicotine dependence and cannabis abuse/dependence; and (iii) estimate heritable variation in and covariation between the factors. DESIGN Factorial and exploratory structural equation modeling was conducted to examine the factor structure of initial reactions. Cox proportional hazards modeling was employed to examine their association with time to onset of diagnosis of DSM-IV nicotine dependence and cannabis abuse/dependence. Classical twin modeling, using univariate and multivariate models, was used to parse variance in each factor (and the covariance between factors) to their additive genetic, shared environmental and non-shared environmental sources. SETTING AND PARTICIPANTS General population sample of Caucasian female twins aged 18-32 years, with a life-time history of tobacco [n = 2393] and cannabis [n = 1445] use. MEASUREMENT Self-report of initial subjective reactions to tobacco (cigarettes) and cannabis the first time they were used and time to onset of life-time history of DSM-IV diagnosis of abuse (cannabis) and dependence (cannabis or nicotine). FINDINGS Factors representing putatively positive and negative reactions to cannabis and tobacco emerged. Initial reactions to tobacco were associated with onset of DSM-IV diagnosis of nicotine dependence and cannabis abuse/dependence while initial reactions to cannabis were associated with onset of DSM-IV diagnosis of cannabis abuse/dependence alone. Genetic factors played a moderate role in each factor (heritability of 27-35%, P < 0.05), with the remaining variance attributed to individual-specific environment. Covariation across the factors indexing positive and negative initial reactions was attributable to genetic sources (0.18-0.58, P < 0.05) and to overlapping individual-specific environmental factors (-0.16 to 0.36, P < 0.05). CONCLUSIONS Initial subjective reactions to tobacco are associated with onset of DSM-IV diagnosis of nicotine dependence and cannabis abuse/dependence while initial subjective reactions to cannabis are only associated with onset of diagnosis of DSM-IV cannabis abuse/dependence. Genetic and environmental factors underpin the overlap across the factors representing initial reactions, both positive and negative.
The influence of the noninvasive follicular thyroid neoplasm with papillary‐like nuclear features (NIFTP) resection diagnosis on the false‐positive thyroid cytology rate relates to quality assurance thresholds and the application of NIFTP criteria

Noninvasive follicular thyroid neoplasm with papillary‐like nuclear features (NIFTP) is a newly defined entity and recent studies have suggested a decrease of a few percentage points in the rate of malignancy (ROM) for the positive‐for‐malignancy (PFM) cytology category as a result of NIFTP implementation. However, the distinction between a diagnosis of PFM and one of suspicious for malignancy (SFM) may depend on a variety of factors. In the current study, the authors investigated the ROM for the PFM and SFM diagnoses before and after histologic NIFTP reclassification.
An Archival Approach to Measuring Family Influence

Drawing from a framework highlighting how family influence is reflected in organizational identity, we present archival and content analytic adaptations for three key factors signifying alignment between family and organizational identities: family visibility, transgenerational sustainability, and family self-enhancement. We validate these measures using archival data sources, “About Us” pages, and shareholder letters from S&P 500 firms. Random coefficients modeling indicates our measures are largely shaped by temporal and firm, followed by industry, differences. Our work paves the way for further investigation exploring the relationships between family involvement and organizational identity while simultaneously addressing lingering methodological challenges in family business research.
Ex vivo comparison of single‐layer and double‐layer laparoscopic closure of equine bladders with 2 types of barbed sutures

OBJECTIVE To compare laparoscopic single-layer versus double-layer closure of experimental, full-thickness incisions in adult equine urinary bladders using unidirectional and bidirectional barbed suture. STUDY DESIGN Experimental, ex vivo, surgical study. SAMPLE POPULATION Thirty adult equine cadaver urinary bladders. METHODS Bladders were randomly divided into 5 groups (n = 6): intact controls, bladders sutured with unidirectional or bidirectional barbed suture in a single-layer closure, and bladders sutured with unidirectional or bidirectional barbed suture in a double-layer closure. A 5-cm apical incision was created in each bladder assigned to a suture group, prior to closure in a laparoscopic trainer. After suturing, bursting pressures (BPs) were determined by filling the bladders with saline to failure. Continuous variables were compared among groups using generalized linear modeling with post hoc testing between groups, and categorical variables were compared using Fisher's exact test. Significance was set at P < . 05. RESULTS No difference in BP was detected between treatment groups, all failing at pressures lower than those of intact bladders. The 95% confidence interval for BPs exceeded a physiologically relevant threshold of 30 mm Hg after single-layer or double-layer closure. Irrespective of treatment group, surgical time decreased with experience, and the rate of reduction was greater for the single-layer than the double-layer closures. CONCLUSION In this ex vivo study, both closure techniques and both suture types appeared to be acceptable for laparoscopic closure of the urinary bladder in adult horses.
Stable Bipolar Resistive Switching Characteristics and Resistive Switching Mechanisms Observed in Aluminum Nitride-based ReRAM Devices

The authors report upon the ultrafast bipolar switching characteristics observed in aluminum nitride (AlN)-based resistive random access memory devices ReRAMs. The set and reset states were measured to be as low as 2 μA and 5 nA, respectively, at Vread = 0.1&nbsp;V. Regarding pulse operations, very fast switching characteristics were achieved at 3 V/10 ns for the set operation and -3 V/10 ns for the reset operation. In addition, the AlN-based ReRAMs showed an endurance value of over ~ 108 cycles and a retention time of over ten years at 85°C. These results show that this AlN-based ReRAM can be used as a promising high-speed nonvolatile memory device.