Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of the COP9 Signalosome (CSN) in Cardiovascular Diseases

The constitutive photomorphogenesis 9 (COP9) signalosome (CSN) is an evolutionarily conserved multi-protein complex, consisting of eight subunits termed CSN1-CSN8. The main biochemical function of the CSN is the control of protein degradation via the ubiquitin-proteasome-system through regulation of cullin-RING E3-ligase (CRL) activity by deNEDDylation of cullins, but the CSN also serves as a docking platform for signaling proteins. The catalytic deNEDDylase (isopeptidase) activity of the complex is executed by CSN5, but only efficiently occurs in the three-dimensional architectural context of the complex. Due to its positioning in a central cellular pathway connected to cell responses such as cell-cycle, proliferation, and signaling, the CSN has been implicated in several human diseases, with most evidence available for a role in cancer. However, emerging evidence also suggests that the CSN is involved in inflammation and cardiovascular diseases. This is both due to its role in controlling CRLs, regulating components of key inflammatory pathways such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and complex-independent interactions of subunits such as CSN5 with inflammatory proteins. In this case, we summarize and discuss studies suggesting that the CSN may have a key role in cardiovascular diseases such as atherosclerosis and heart failure. We discuss the implicated molecular mechanisms ranging from inflammatory NF-κB signaling to proteotoxicity and necrosis, covering disease-relevant cell types such as myeloid and endothelial cells or cardiomyocytes. While the CSN is considered to be disease-exacerbating in most cancer entities, the cardiovascular studies suggest potent protective activities in the vasculature and heart. The underlying mechanisms and potential therapeutic avenues will be critically discussed.
How are germination performance and seedling establishment under abiotic stress improved by seed priming?: A review

Seed priming, also called osmoconditioning, is one of the most promising treatments for reducing the time needed between sowing and seedling emergence. In addition, this treatment has also been associated with increases in seed tolerance to adverse conditions during seed germination and seedling establishment. Thus, this review examines the major changes seen in abiotically stressed plants as a result of seed priming treatments, in particular physiological and biochemical changes promoted by seed priming. Many studies cited in this review have reported improvements in seed physiological quality and seedling vigour when using seed priming under abiotic stress conditions. These features have been related to the repair and build-up of nucleic acids, increases in the synthesis of proteins, osmotic adjustment mechanisms, the repair of membranes and reduced lipid peroxidation, resulting from enhanced antioxidative activities. However, further studies are necessary to explain how physiological and biochemical changes caused by seed priming improve the plant's adaptations to stressful environmental conditions.
Avatars and the Disease: Digital Customization as a Resource for Self-Perception Assessment in Breast Cancer Patients

Avatars, or users' renditions within digital environments, may change depending on modifications of users' self-conception. According to literature, chronic health conditions influence patients and survivors' identity, because living with a disease requires people to reconfigure their self-representation and their own daily life and future plans. This is especially true for breast cancer, whose treatment and surgery also affect patients' body image, sexual identity, and sense of womanhood. In this study, 22 breast cancer survivors were asked to create multiple avatars resembling their actual self (AS), their ideal self (IS), and their self connected to the disease experience; then, they were asked to rate their attitudes toward their three avatars. Results show that disease avatars are significantly different in patients' attitudes toward them from AS and IS avatars. In addition, attitudes toward one's own avatars appeared partially related to clinically relevant psychological states, such as anxiety and depression. Discussion explores suggestions for usage of avatars in interventions for assessment and quality-of-life promotion among chronic patients.
THE EFFECTS OF ACTOR ATTRACTIVENESS AND ADVERTISEMENT CHOICE ON MECHANICAL AVOIDANCE BEHAVIORS

Two common types of advertisement avoidance behaviors in digital domains are skipping and zipping. Skipping involves pressing a “skip ad” button when viewing television content online, and zipping involves pressing a fast-forward button when viewing the same content through some type of recording device (e.g. Digital Video Recording device). The purpose of these studies was to examine if specific factors regarding the content of the advertisement, the persuasion context, and characteristics of the viewer reduce occurrences of skipping and zipping behavior. Participants in these two studies saw a combination of television shows and advertisements. One target advertisement marketed a fictional MP3 player while another discussed the dangers of binge drinking. One version each of the MP3 and binge drinking advertisements contained average-looking (i.e. normal) actors, and the other half contained above-average-looking (i.e. attractive) actors. Half of the viewers were allowed to choose which type of advertisements they would watch while the other half were forced to watch a particular type. The results of one study showed that participants were more likely to skip the MP3 advertisement than the binge drinking advertisement after making an advertisement choice when both contained normally attractive actors. These findings demonstrate that the effect of advertisement choice may be more complicated than previously found. Instead of acting as a means to improve avoidance rates, advertisement choice may make the content more salient to participants. Thus, viewers’ perceptions of the advertisement after making an advertisement choice may determine whether avoidance occurs. THE EFFECTS OF ACTOR ATTRACTIVENESS AND ADVERTISEMENT CHOICE ON MECHANICAL AVOIDANCE BEHAVIORS
How to Reduce Batch-Size

One of the key elements of lean is the elimination of internal inventories along the production line. However, even though the benefits from reducing inventories theoretically are well described (increased learning, visible bottlenecks and reduced capital costs and production time etc.), the concept is not easily introduced at the construction site. Thus, this mainly empirical paper aims at investigating the question: "How can significant reduction in batchsizes be achieved at the construction site". More precisely it is investigated if reduced building time is a way of forcing a reduction in batch-size at the construction site. In order to answer this question, two projects carried out by MT H0jgaard are used as case studies. Both projects have been subject to considerable reduction in the building period, although for different reasons. The paper at one hand illustrates, partly due to reduced batch-size, that it is possible to make significant reductions in construction durations and at the same time maintain and perhaps improve quality, cost and work environment on site. At the same time the case studies show that it is dangerous to reduce building time if the right contingencies are not in place. In particular, the way project management handles time pressure is of essence in this respect. The involvement of the construction crews working on site in the decision making and ongoing planning seem to be far a more efficient way of handling time pressure than by centralizing decisions at the project management level and as part of this increase the amount and richness of time schedules. Hence, this study supports the idea that The Last Planner System has an important role to play in reducing batch-size in construction. The possibility of designing activities in ways where fewer hand-overs are needed is an important way of gaining time. Experience from previous projects is also of vital importance as it allows subcontractors to be honest about their real time consumption. In this way, the case studies suggest that there is a positive interaction between reductions in building time and batch-size on one side and The Last Planner System together with the concepts of partnering and supply chain management on the other.
Finding The Best Feeding Point Location Of Patch Antenna Using HFSS

This paper describes about the finding of an optimal location of feeding location for patch antenna by using Ansoft HFSS software. The dimensions of patch antenna were calculated based on the three essential parameters. The operation frequency of patch antenna was designed at 2.4 GHz. The LaAlO3 was chosen as a substrate material for the designed patch antenna with a dielectric constant of 23.5, and a height of 1.5 mm. The materials were chosen as a perfect conductor for patch and ground plane with a cut off area from a substrate block. The centre of the patch as well as substrate is located at the origin coordinates of x-y plane, and the height of substrate at z-direction. The objective of this paper is to find the best feed point location, which achieves the highest performance for the designed antenna. The best feed point is located at (Xm, Yn) from the origin. The simulation was done for all feed point locations. The return loss was calculated, and it has the highest value of return loss at a constant y-axis point along the length of patch antenna. The results demonstrated that the use of such a design will achieve high directivity, gain, efficiency, and performance.
Coping Strategies and Quality of Life of Children with Type 1 Diabetes Mellitus: A Preliminary Study

ABSTRACT This study was conducted to identify the correlations between the coping strategies and the quality of life of children with type 1 diabetes mellitus (T1DM). This cross-sectional study involved 39 children from 13 to 18 years old with T1DM who were selected using the consecutive sampling technique. The Pediatric Quality of Life Inventory 3.2 and Coping with a Disease questionnaire were used for this research, and the statistical analysis was conducted using the Pearson and Spearman correlation tests. The average age of the participants was 15.23 years old (± 1.81), they had been diagnosed with T1DM for an average of 5.54 years (± 3.06), and 59% were females. The most commonly used coping method was wishful thinking, and the quality of life mean was 63.82. The emotional reaction (p = 0.009, r = −0.413) and acceptance (p = 0.049. r = 0.317) coping strategies were significantly correlated with the quality of life. However, the other four coping strategies had no significant correlations with the quality of life. These study findings suggest that nurses should help to prevent children with T1DM from adopting emotional reactions as long-term coping mechanisms. Moreover, they should promote the use of the acceptance coping mechanism when providing nursing care for children with T1DM.
Impact of aerosol size distribution on extinction and spectral dependence of radiances measured by the OMPS Limb profiler instrument

Abstract. The Ozone Mapping and Profiler Suite Limb Profiler (OMPS/LP) has been flying on the Suomi NPP satellite since Oct 2011. It is designed to produce ozone and aerosol vertical profiles at ~ 2 km vertical resolution over the entire sunlit globe. The current operational (V1) aerosol extinction retrieval algorithm assumes a bimodal lognormal aerosol size distribution (ASD) whose parameters were derived from in situ data taken from an aircraft. In this paper we discuss the impact on the retrieval of using an ASD derived by the Community Aerosol and Radiation Model for Atmospheres (CARMA). We find that the impact of ASD on the retrieved extinctions varies strongly with the underlying reflectivity of the scene, and the functional form of this variation is very different at different scattering angles. We also evaluate how well the two ASDs perform in explaining the spectral dependence of Aerosol Scattering Index (ASI); a dimensionless quantity that we derive from the measured radiances by subtracting out the Rayleigh contribution. ASI is easier to interpret than radiances themselves and serves as our measurement vector. The results show that even though the two ASDs produce very different aerosol scattering phase function values at small and large scattering angles, the effect of the ASD on the spectral dependence of ASI is significant only at small angles. This implies that while OMPS/LP measurements have some information to evaluate the ASDs, they are most effective only at small scattering angles, which for LP measurement geometry occur only in the northern hemisphere. Our analysis suggests that overall CARMA ASD does a better job in explaining the spectral dependence of measured ASI than the ASD used in the operational V1 algorithm.
RETROSPECTIVE: New Attacks and Defense for Encrypted-Address Cache

This ISCA-2019 paper was a follow-up to our prior MICRO-2018 paper (CEASER), which proposed a low-cost randomized cache design using encrypted-address. This paper proposed faster eviction-set algorithms, which broke prior secure caches, and a robust randomized cache (CEASER-S). This paper represented a significant jump in both attacks and defense for randomized caches. Personally, this was truly a fun paper, where for several months, I had posed the problem of eviction-set generation as a ”spy” problem to dozens of people, to see if they could come up with an even better solution. The second attack that exploits the replacement policy was discovered accidentally while making the conference slides for MICRO-2018. Finally, the solution was a simple combination of CEASER with Seznec’s brilliant idea of skewing. We hope to share the backstory, the context, and the impact of the paper.
The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs

Tryptophan-derived metabolites from the gut microbiota control miR-181 expression in mouse white adipocytes to regulate metabolism and inflammation. A gut-fat axis Whether and how the gut microbiome affects adipose tissue homeostasis is an area of current investigation. Virtue et al. showed that a high-fat diet in mice led to the activation of miR-181 in white adipose tissue (WAT) and subsequent obesity, insulin resistance, and WAT inflammation. The authors tied the increased expression of this microRNA to a reduction in circulating microbiota-derived metabolites produced by tryptophan metabolism in the gut and confirmed this link by administering indole to mice. miR-181 was increased in WAT and indole was reduced in the plasma of obese humans, suggesting the potential relevance of this axis to human disease. The gut microbiota is a key environmental determinant of mammalian metabolism. Regulation of white adipose tissue (WAT) by the gut microbiota is a process critical to maintaining metabolic fitness, and gut dysbiosis can contribute to the development of obesity and insulin resistance (IR). However, how the gut microbiota regulates WAT function remains largely unknown. Here, we show that tryptophan-derived metabolites produced by the gut microbiota controlled the expression of the miR-181 family in white adipocytes in mice to regulate energy expenditure and insulin sensitivity. Moreover, dysregulation of the gut microbiota–miR-181 axis was required for the development of obesity, IR, and WAT inflammation in mice. Our results indicate that regulation of miR-181 in WAT by gut microbiota–derived metabolites is a central mechanism by which host metabolism is tuned in response to dietary and environmental changes. As we also found that MIR-181 expression in WAT and the plasma abundance of tryptophan-derived metabolites were dysregulated in a cohort of obese human children, the MIR-181 family may represent a potential therapeutic target to modulate WAT function in the context of obesity.
Effects of peatland drainage management on peak flows

Open ditch drainage has historically been a common land management practice in upland blanket peats, particularly in the UK. However, peatland drainage is now generally considered to have adverse effects on the upland environment, including increased peak flows. As a result, drain blocking has become a common management strategy in the UK over recent years, although there is only anecdotal evidence to suggest that this might decrease peak flows. The change in the hydrological regime associated with the drainage of blanket peat and the subsequent blocking of drains is poorly understood, therefore a new physics-based model has been developed that allows the exploration of the associated hydrological processes. A series of simulations is used to explore the response of intact, drained and blocked drain sites at field scales. While drainage is generally found to increase peak flows, the effect of drain blocking appears to be dependent on local conditions, sometimes decreasing and sometimes increasing peak flows. Based on insights from these simulations we identify steep smooth drains as those that would experience the greatest reduction in field-scale peak flows if blocked and recommend that future targeted field studies should be focused on examining surface runoff characteristics.
The role of lncRNA RP11‐154D6 in steroid‐induced osteonecrosis of the femoral head through BMSC regulation

Bone marrow stem cells (BMSCs) are involved in steroid‐induced osteonecrosis of the femoral head (ONFH). Long noncoding RNAs (lncRNAs) have been demonstrated to regulate functions of BMSCs, especially their differentiation, and have been reported to be implicated in diverse bone disorders. However, the roles of lncRNAs in the progression of steroid‐induced ONFH remain unknown.
Does economic growth really depend on the magnitude of debt? A threshold model approach

In recent economic literature it has been emphasized that across both advanced countries and emerging markets, high levels of debt-to-gross domestic product (GDP) ratio (90% and above) are associated with notably lower growth outcomes. On the other hand, much lower levels of external debt-to-GDP ratio (60% and below) are associated with adverse outcomes for emerging market growth. These findings have been broadly cited and used in practice. On the other hand, there is an opposite evidence, such that the initial level of debt-to-GDP ratio has no impact on economic growth rate. Taking both viewpoints into account, we propose to employ a time series-based nonlinear mechanism in the threshold autoregression form in order to examine the possible relationship between economic growth rate and its potential determinants included the mentioned debt-to GDP indicator. The originality of the study is that it employs threshold variables instead of exogenous variables and time-series data instead of panel data to reveal the economic instruments that have determined the business cycle in European countries for the last 2 decades -starting from 1995. The purpose of the study is to check the mechanism of growth (measured in terms of GDP growth rate and industrial production growth rate) depending on several important macroeconomic variables, such as public debt, rate of inflation, interest rate, and rate of unemployment with the level of growth itself serving as the threshold variable. We propose an efficient methodology for seeking the best specification of threshold autoregression model in terms of both goodness of fit and parsimony of parametrization. The data (quarterly and monthly) applied in the research cover the time period from the beginning of 1995 to the end of 2013. Such a long period is interesting because it allows investigation of the mechanism of growth under two different economic policy models. We identify that the exogenous monetary mechanism played an important role in diagnosing the phases of business cycle in most European economies which is in line with liberal economic policy dominating in the observed period. The initial level of debt-to-GDP ratio as its increase within the recession period was of no value for the economic growth pattern.
The Extent of Using and Trusting Capital Budgeting Methods in Projects Appraisal in Palestinian Corporations

This research paper aims to find the degree of the use as well as the trust of the Net Present Value (NPV), Payback Period (PBP), Internal Rate of Returns (IRR) and Accounting Rate of Returns (ARR) as a key capital budgeting method. The research conducted on the listed corporations in Palestine which are 48 company. A questionnaire distributed on 77 financial and project/operations managers in these corporations with 67 responds. The result shows that both discounted and non-discounted cash flows methods are used and trusted by Palestine public corporations. However, on the other hand, the above four methods are volatile in term of use and trust. The most used and trusted capital budgeting method is the Payback period (PBP). This followed by the Net Present Value (NPV). Accounting Rate of Retunes (ARR) becomes third. Thus the least used and trusted method is the Internal Rate of Returns (IRR).
Impact of Rhinovirus Infections in Children

Rhinovirus (RV) is an RNA virus that causes more than 50% of upper respiratory tract infections in humans worldwide. Together with Respiratory Syncytial Virus, RV is one of the leading causes of viral bronchiolitis in infants and the most common virus associated with wheezing in children aged between one and two years. Because of its tremendous genetic diversity (>150 serotypes), the recurrence of RV infections each year is quite typical. Furthermore, because of its broad clinical spectrum, the clinical variability as well as the pathogenesis of RV infection are nowadays the subjects of an in-depth examination and have been the subject of several studies in the literature. In fact, the virus is responsible for direct cell cytotoxicity in only a small way, and it is now clearer than ever that it may act indirectly by triggering the release of active mediators by structural and inflammatory airway cells, causing the onset and/or the acute exacerbation of asthmatic events in predisposed children. In the present review, we aim to summarize the RV infection’s epidemiology, pathogenetic hypotheses, and available treatment options as well as its correlation with respiratory morbidity and mortality in the pediatric population.
Innovation and international trade: a non-linear relationship

The aim of this paper is to identify the main determinants of the export activity of firms in with special attention to the role of their innovative behaviour. There exist a broad number of previous studies that analyse this question and reflect a clear prelationship between the firmsinnovative behaviour and the probability and/or intensity of the firms? exports (Exports by sales). In addition, the existing literature defines this relationship as linear, although this paper with empirical data for the Mexican and Spanish case shows that this linear modelling seems to be need a revision. Using a TOBIT model, our data reflect a non-linear relationship in the form of an inverted ? U? between the innovative behaviour and the export intensity. The less innovative firms do have a lower export intensity, followed by the most innovative firms, while the firms with a ? medium innovative level? are the most competitive firms on the world market in terms of export intensity. For each country two models were estimated. First a traditional linear model is estimated and its results coincide with the existing literature and show that our data set is not atypical. Secondly we estimate a non-linear model. This model is econometrically significant and, more important, has a higher explanatory power than the traditional linear model. In other words its superiority in relation to the non-linear model use is justified from an econometric point of view.