Miracle-dz/UniFAR-FTUs huggingface dataset:
Sexual Orientation Disparities in Pregnancy Risk Behaviors and Pregnancy Among Sexually Active Teenage Girls: Updates from the Youth Risk Behavior Survey.

Purpose: The purpose of this study was to determine the extent to which sexual identity and/or sexual behaviors were associated with pregnancy risk factors (condom use, alcohol or other drug use before sex, and World Health Organization [WHO] Tier 1 [i.e., intrauterine device, implant] or Tier 2 [i.e., injectable, pill, patch, or ring] contraception use) and teen pregnancy among female high school students who reported having a sexual relationship with a male partner. Methods: Data were from the Youth Risk Behavior Survey (YRBS; 2005-2015) (n = 63,313). Logistic regression was used to analyze sexual identity and behavior disparities in pregnancy risk behaviors and teen pregnancy. Interactions between sexual identity and behavior were also tested. All models adjusted for the YRBS complex sampling frame. Results: Girls who reported being unsure of their sexual identity were less likely to use condoms or a WHO Tier 1 or Tier 2 contraceptive method at last sex, and more likely to report alcohol or other drug use at last sex than heterosexual girls. Girls who identified as lesbian were also less likely to use a condom at last sex, and girls who reported both male and female sexual partners were more likely to report alcohol or other drug use and less likely to use condoms at last sex. Girls who identified as bisexual were more likely to report pregnancy during teenage years than girls who identified as heterosexual. Conclusion: Our results support the need to assess both sexual identity and sexual behavior in research on teen pregnancy and pregnancy risk. Furthermore, the finding that girls who were unsure of their sexual identity showed heightened risk highlights the need for additional research that includes this group.
Rearing Pigs with Intact Tails—Experiences and Practical Solutions in Sweden

Simple Summary Tail biting is a common problem within modern pig production and is mainly an indicator of poor housing environment where the behavioural needs of pigs are not met. Tail biting causes pain and can result in infection, leading to reduced pig growth and reduced farm profits. In order to prevent tail biting, pigs are often tail docked, without pain relief, within the first week of life. The EU Directive condemns routine tail docking and advises that tail biting can be prevented through improving the environment of pigs. In Sweden, tail docking is banned and all pigs are reared with intact tails. This paper summarises knowledge from Swedish production of undocked pigs and describes practical solutions in use in Sweden that can be applied to pig production in other EU Member States. Housing conditions and management within Swedish pig production, such as stocking density and feeding space, differ in many aspects from those in other EU countries. To prevent tail biting and eliminate the need for tail docking, EU legislation should more clearly match with the biological needs of pigs. Abstract Tail biting is a common issue within commercial pig production. It is mainly an indicator of inadequate housing environment and results in reduced health welfare and production. To reduce the impact of tail biting, pigs are commonly tail docked, without pain relief, within the first week of life. EU Council Directive 2008/120/EC prohibits routine tail docking, but the practice is still widely used in many Member States. Sweden has banned tail docking since 1988 and all pigs have intact tails, yet tail biting is a minor problem. This paper summarises and synthesises experimental findings and practical expertise in production of undocked pigs in Sweden and describes solutions to facilitate a transition to producing pigs with intact tails within intensive pig production in the EU. Swedish pig housing conditions and management differ in many aspects from those in other EU Member States. Swedish experiences show that lower stocking density, provision of sufficient feeding space, no fully slatted flooring, strict maximum levels for noxious gases and regular provision of litter material are crucial for success when rearing pigs with intact tails. To prevent tail biting and to eliminate the need for tail docking, we strongly recommend that EU legislation should more clearly match the biological needs of pigs, as is done in Swedish legislation.
BMP Signaling in Development, Stem Cells, and Diseases of the Gastrointestinal Tract.

The bone morphogenetic protein (BMP) pathway is essential for the morphogenesis of multiple organs in the digestive system. Abnormal BMP signaling has also been associated with disease initiation and progression in the gastrointestinal (GI) tract and associated organs. Recent studies using animal models, tissue organoids, and human pluripotent stem cells have significantly expanded our understanding of the roles played by BMPs in the development and homeostasis of GI organs. It is clear that BMP signaling regulates GI function and disease progression that involve stem/progenitor cells and inflammation in a tissue-specific manner. In this review we discuss these new findings with a focus on the esophagus, stomach, and intestine. Expected final online publication date for the Annual Review of Physiology, Volume 82 is February 10, 2020. Please see http://www.annualreviews. org/page/journal/pubdates for revised estimates.
A comparison of Pakistani and Caucasian mothers' perceptions of child and adolescent mental health problems

Abstract Pakistani and Caucasian mothers were both highly accurate in the identification of child and adolescent mental health problems. In a community-based vignettes study, Caucasian mothers were more likely to identify all behaviours as problematic. However, Pakistani mothers who did identify behaviours as problematic then rated them as being as (or more) serious than the Caucasian mothers. Despite this, Pakistani mothers were less likely to seek treatment from local child and adolescent mental health services.
Peer support in Switzerland - Results from the first national survey.

Peer work is now known in Switzerland for 10 years and has developed strongly. The aim of the study was to describe peer support specialists' (PSSs') work conditions and job satisfaction, as well as the challenges of integration into the workforce in Switzerland. A further aim was to identify possible development topics in the preparation of PSSs for working with peer support work (PSW) training and interventions within the working field. We launched a survey with a self-developed questionnaire for people with lived experiences with mental illness and recovery who were working as PSSs or experts by experience in education, research, politics, and other areas in the German-speaking region of Switzerland. The survey took place from 1 September 2017 to 15 November 2017. The results show that PSSs were working mostly in 1:1 contact with service users and in education and noticeably less in politics and research. Their work conditions and job satisfaction seemed good. Most PSSs had job descriptions matching their duties, were satisfied with their salaries, and indicated being satisfied or very satisfied with their work. Amongst other aspects, the greatest challenge reported was integration into the inter-disciplinary working team. PSS training should better consider the working areas of experts by experience in the fields of politics and research to reinforce employment opportunities in these work areas. To increase the impacts of PSSs and to improve integration into the workspace, the preparation of professionals and institutions should be improved by means of information sessions, trainings, and guidelines.
Total Quality Management Applications in the Saudi University Information Centres

I ACKNOWLEDGEMENTS . II TABLE OF CONTENTS . III LIST OF TABLES . X LIST OF FIGURES . XII GLOSSARY OF ABBREVIATIONS AND ACRONYMS. XIII LIST OF PRESENTATIONS ARAISING FROM THE THESIS . XIV CHAPTER ONE: INTRODUCTION .
Evaluation and comparison of pain questionnaires for clinical screening of osteoarthritis in cats

Background Feline osteoarthritis (OA) is a common cause of long-standing pain and physical dysfunction. Performing a physical examination of a cat is often challenging. There is a need for disease-specific questionnaires or the so-called clinical metrology instruments (CMIs) to facilitate diagnosis and evaluation of treatment of feline OA. The CMI provides the owners an assessment of the cat’s behavioural and lifestyle changes in the home environment. The purpose of the study was to evaluate readability, internal consistency, reliability and discriminatory ability of four CMIs. Methods This is a prospective, cross-sectional study with 142 client-owned cats. Feline OA was diagnosed based on medical history, orthopaedic examination and radiography. Results The results indicate that all four instruments have sound readability, internal consistency, are reliable over time and have good discriminatory ability. Preliminary cut-off values with optimal sensitivity and specificity were suggested for each instrument. The osteoarthritic cats showed significant changes in behavioural response to pain during orthopaedic examination, compared with sound cats. Conclusion The results indicate that all four questionnaires make an important contribution in a clinical setting, and that the cat’s behavioural response to pain during physical examination should be a parameter to take into account as a possible indication of chronic pain.
Platelets and Hepatocellular Cancer: Bridging the Bench to the Clinics

Growing interest is recently being focused on the role played by the platelets in favoring hepatocellular cancer (HCC) growth and dissemination. The present review reports in detail both the experimental and clinical evidence published on this topic. Several growth factors and angiogenic molecules specifically secreted by platelets are directly connected with tumor progression and neo-angiogenesis. Among them, we can list the platelet-derived growth factor, the vascular endothelial growth factor, the endothelial growth factor, and serotonin. Platelets are also involved in tumor spread, favoring endothelium permeabilization and tumor cells’ extravasation and survival in the bloodstream. From the bench to the clinics, all of these aspects were also investigated in clinical series, showing an evident correlation between platelet count and size of HCC, tumor biological behavior, metastatic spread, and overall survival rates. Moreover, a better understanding of the mechanisms involved in the platelet–tumor axis represents a paramount aspect for optimizing both current tumor treatment and development of new therapeutic strategies against HCC.
The Select Committee Report on Obesity (2004): The significant omission of parental views of their children's eating

Many studies have reported increasing levels of obesity and overweight in children. Recent policy developments have examined a range of influences on children's eating habits but have left largely unexamined the role of parents in general and mothers in particular. In this study we examined mothers’ understandings of healthy eating and of their influence on their children's eating patterns. Semi-structured interviews were conducted with nine mothers of children aged between 4 and 12 years of age. Interviewees displayed knowledge of recommended eating practices for their children but distinguished this knowledge from actual eating practices. Avoidance of negative social perceptions, pleasure in eating and opportunities for fast food were regarded as more important than eating in accordance with recommended nutritional guidelines. Moreover, the food choices made were viewed as positive alternatives to eating based on nutritional balance. These views pose a challenge for policy initiatives to address obesity and excess weight in children. Future initiatives should have increased regard for the everyday contexts within which children's eating patterns are understood and justified.
The load dependence and the force-velocity relation in intact myosin filaments from skeletal and smooth muscles.

In the present study we evaluated the load dependence of force produced by isolated muscle myosin filaments interacting with fluorescently labeled actin filaments, using for the first time, whole native myosin filaments. This was made possible by using a newly developed approach that allowed the use of physiological levels of ATP. Single filaments composed of either skeletal or smooth muscle myosinand single filaments of actin were attached between pairs of nano-fabricated cantilevers of known stiffness. The filaments were brought into contact to produce force, which caused sliding of the actin filaments over the myosin filaments. We applied load to the system by either pushing of pulling the filaments during interactions, and observed that increasing the load increased the force produced by myosin and decreasing the load decreased the force. We also performed additional experiments in which we clamped the filaments at pre-determined levels of force, which caused the filaments to slide to adjust the different loads, allowing us to measure the velocity of length changes to construct a force-velocity relation. Force values were in the range observed previously with myosin filaments and molecules. The force-velocity curves for skeletal and smooth muscle myosins resembled the relations observed for muscle fibers. The technique can be used to investigate many issues of interest and debate in the field of muscle biophysics.
Enzymatically-gellable gelatin improves nano-hydroxyapatite-alginate microcapsule characteristics for modular bone tissue formation.

To maintain gelatin (Gel) as adhesive motifs inside alginate microcapsule as building blocks of modular approach, phenol moiety (Ph) was introduced into gelatin (Gel Ph). Addition of Gel Ph to alginate (Alg-Gel Ph) dramatically altered the physical properties of alginate-based hydrogels as compared to unmodified gelatin (Alg-Gel) addition. Alg-Gel Ph hydrogels revealed a dramatically lower swelling ratios (63%) as compared to Alg-Gel hydrogels (150%). Moreover, Gel Ph decreased 40% degradation rate of alginate-based hydrogels after 72h, while increasing compressive modulus 3.5-fold as compared to Alg-Gel hydrogels. Introducing nano-hydroxyapatite (nHA) to Alg-Gel Ph hydrogel (Alg-Gel Ph-nHA) could reduce degradation rate to 41.5% and improve compressive modulus of hydrogels significantly, reaching to 294±2.5 kPa. The microencapsulated osteoblast-like cells proliferated considerably and showed more metabolic activities (two times) in Alg-Gel Ph-nHA microcapsules during a 21-day culture period, resulting in more calcium deposition and alkaline phosphatase (ALP) activities. The subcutaneous microcapsules could also be identified readily without complete absorption and signs of toxicity or any untoward reactions and viable osteoblast-like cells were seen as red colored areas in the central regions of cell-laden microcapsules after one month. The study demonstrated Alg-Gel Ph-nHA microcapsule as a promising 3D microenvironment for modular bone tissue formation. This article is protected by copyright. All rights reserved.
Breaking a Vital Trust: Posting Photos of Patients on Facebook Among a Sample of Peruvian Medical Students

Abstract Background: The doctor-patient relationship may be affected by the indiscriminate use of social media platforms. The aim of this study was to evaluate the content of the photos posted on medical students’ Facebook accounts to determine whether they have posted private patient information and compare this to their self-reported behavior of posting such photos. Methods: We performed a cross-sectional study of medical students from a Peruvian private university. With their permission, we reviewed their Facebook accounts for the publication of photos or documents that included private patient information (face, name, diagnosis, medical exams). Those who allowed access to their Facebook accounts were also asked to complete an online survey. We assessed variables related to sociodemographic aspects, self reported Facebook use, and what type of private patient information they posted. Results: A total of 160/220 students joined the study, 59% were women, mean age: 20 years. 25.7% self-reported having posted private patient information in their Facebook profiles but we found such information on 33.1% of the students’ pages. Of the pages where private patient information was found, in 94% of cases, the patients’ faces were identifiable, and in 7.6%, the patients’ real names appeared. However, only half of the students believed that the information in their Facebook post might affect or influence the doctor-patient relationship. Association with narcissism, gender, and account privacy was not found. Having uploaded more than 250 photos (OR:2.90; CI95%:1.14-7.39) and posting photos tagged with the location of a hospital (OR:4.02; CI95%:1.36-11.9) were associated with having posted photos containing private patient information. Conclusion: One out of three of medical students posted patients’ private information on their personal Facebook profiles. Development, dissemination, and implementation of guidelines related to ethics in social media platforms are needed.
Predictive Power of Liver Maximum Function Capacity Test in Transjugular Intrahepatic Portosystemic Shunt Patients: A Pilot Study

Background: Transjugular intrahepatic shunt (TIPSS) is placed in patients with variceal bleeding, refractory ascites, and for other indications. Postprocedural liver function-associated complications (LFAC), including hepatic encephalopathy (HE) and liver failure, represent a major setback. Current methods to predict complications are insufficient. Objectives: We investigated in a pilot study of patients prior TIPSS placement whether the risk of LFAC correlates with the functional reserve of the liver, as assessed by liver maximum function capacity (LiMAx) test. Methods: Prospectively we included patients prior TIPSS placement between June 2016 and November 2017 at Saarland University Medical Center. LiMAx was conducted before and after TIPSS placement. Patients with HE prior TIPSS, as well as other factors predisposing to HE, including concomitant sedative drugs, current bacterial infections and sepsis, were excluded. Overt HE (OHE), LiMAx, and laboratory values were assessed before and after TIPSS placement. Data were analyzed in multivariate regression and AUROC models. Results: Mean age was 60 ± 8 years. Patients (n = 20) were mainly men (65%), and presented predominantly with Child-Pugh class B (90%). Indications for TIPSS were most commonly refractory ascites or recurrent variceal bleeding. In total, 40% of the patients developed LFAC after TIPSS placement. Expectedly, LiMAx decreased and serum bilirubin increased after TIPSS. LiMAx drop ≥20% was the only parameter predicting the development of LFAC after TIPSS in multivariate regression and AUROC analysis. Conclusions: In multivariate regression models and AUROC analysis, a drop in LiMAx predicted the development of LFAC after TIPSS placement. Additional larger studies assessing OHE and early liver failure separately are warranted.
Velamentous cord insertion in monochorionic twin gestation. An added risk factor.

OBJECTIVE To study the effects of umbilical cord insertion combinations on outcomes in monochorionic (MC) twin placentas. STUDY DESIGN Sixty consecutive MC placentas were analyzed by cord insertion patterns with regard to growth discordance, placental parenchymal sharing, types and patterns of intertwin vascular anastomoses, perinatal mortality and frequency of fetofetal transfusion. Cord insertions were classified as central/eccentric (CEN) or velamentous/marginal (VEL). RESULTS Forty-five percent of the twins had VEL insertions. The CEN/VEL combination was found in 53% of pairs. The CEN/VEL group had the highest rates of growth discordance > 20%, unequal placental parenchymal sharing, uncompensated anastomoses and perinatal demise. CONCLUSION VEL cord insertion and the CEN/VEL combination are indicators of high-risk subgroups within MC twins. VEL cord insertions can be diagnosed by ultrasound, identifying these high-risk groups.
A regimen containing bedaquiline and delamanid compared to bedaquiline in patients with drug-resistant tuberculosis

There are limited data on combining delamanid and bedaquiline in drug-resistant tuberculosis (DR-TB) regimens. Prospective long-term outcome data, including in HIV-infected persons, are unavailable. We prospectively followed up 122 South African patients (52.5% HIV-infected) with DR-TB and poor prognostic features between 2014 and 2018. We examined outcomes and safety in those who received a bedaquiline-based regimen (n=82) compared to those who received a bedaquiline–delamanid combination regimen (n=40). There was no significant difference in 6-month culture conversion (92.5% versus 81.8%; p=0.26) and 18-month favourable outcome rate (63.4% versus 67.5%; p=0.66) in the bedaquiline versus the bedaquiline–delamanid combination group, despite the latter having more advanced drug resistance (3.7% versus 22.5% resistant to at least five drugs; p=0.001) and higher pre-treatment failure rates (12.2% versus 52.5% with pre-treatment multidrug-resistant TB therapy failure; p<0.001). Although the proportion of prolongation of the QT interval corrected using Fridericia's formula was higher in the combination group (>60 ms from baseline (p=0.001) or >450 ms during treatment (p=0.001)), there were no symptomatic cases or drug withdrawals in either group. Results were similar in HIV-infected patients. A bedaquiline–delamanid combination regimen showed comparable long-term safety compared to a bedaquiline-based regimen in patients with DR-TB, irrespective of HIV status. These data inform regimen selection in patients with DR-TB from TB-endemic settings. A bedaquiline–delamanid combination regimen in drug-resistant tuberculosis patients with poor prognostic factors showed comparable efficacy and safety to those in a bedaquiline-based regimen http://bit.ly/32j7Fyo
Interleukin‐34 mediated by hepatitis B virus X protein via CCAAT/enhancer‐binding protein α contributes to the proliferation and migration of hepatoma cells

Interleukin‐34 (IL‐34) is associated with hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC). However, the role and associated mechanisms of IL‐34 in HBV‐related HCC remain unclear. In this study, the expression, biological function and associated mechanisms of IL‐34 in HBV‐related HCC cells were investigated.