Remedial effect of aqueous extract of whole plant of Fumaria vaillantii Loisel and ripe fruit of Benincasa hispida Thunb in ranitidine induced-hypochlorhydric male rat

Summary: Prolonged uses of anti-gastric drugs such as ranitidine, omeprazole, famotidine suppress the gastric acid secretion and raise the gastric pH that creates a suitable environment for gastric infection by Helicobacter pylori . These drugs also reduce the vitamin C concentration in gastric juice and also in plasma. Standard concentration of vitamin C in gastric juice helps iron absorption and reduces the occurrence of gastric cancer. Therefore, hypochlorhydria is a risk factor of gastric carcinoma, Helicobacter pylori infection and anemia. In this study hypochlorhydria was (pH ³ 4) induced by ranitidine, a histamine receptor antagonist, and the aim of this present study is to evaluate the protective effect of pre-administration followed by co-administration of aqueous extract of whole plant of Fumaria vaillantii L. (AEFV) or ripe fruit of Benincasa hispida T. (AEBH) in individual as well as by composite manner in ranitidine-induced hypochlorhydric rat. We measured the pH, free acidity and total acidity, vitamin C concentration of gastric juice along with levels of vitamin C in plasma and hemoglobin in blood. These herbal extracts recovered the gastric secretion and it gave satisfactory results in vitamin C concentration in gastric juice though the composite extract is more potent than individual in this aspect. This study highlighted the protective activity of these two plants from the hypochlorhydric state. Industrial relevance: Herbal drugs are used for the treatment of different types of gastrointestinal ailments in Ayurveda. Hypochlorhydria is the common problemsof the older people due to aging and also problem of the different aged people due to unnecessary use of anti-secretory drugs. Now a day, hypochlorhydria is controlled by supplementation of betaine-HCl with pepsin, but its excess use can cause irritation in the gastric mucosa. These herbal extracts gave promising results in recovery of the hypochlorhydria without any toxic effect. So, this study would be helpful for the industry to develop herbal formulated standard drug for the treatment of hypochlorhydria. Summary: Prolonged uses of anti-gastric drugs such as ranitidine, omeprazole, famotidine suppress the gastric acid secretion and raise the gastric pH that creates a suitable environment for gastric infection by Helicobacter pylori . These drugs also reduce the vitamin C concentration in gastric juice and also in plasma. Standard concentration of vitamin C in gastric juice helps iron absorption and reduces the occurrence of gastric cancer. Therefore, hypochlorhydria is a risk factor of gastric carcinoma, Helicobacter pylori infection and anemia. In this study hypochlorhydria was (pH ³ 4) induced by ranitidine, a histamine receptor antagonist, and the aim of this present study is to evaluate the protective effect of pre-administration followed by co-administration of aqueous extract of whole plant of Fumaria vaillantii L. (AEFV) or ripe fruit of Benincasa hispida T. (AEBH) in individual as well as by composite manner in ranitidine-induced hypochlorhydric rat. We measured the pH, free acidity and total acidity, vitamin C concentration of gastric juice along with levels of vitamin C in plasma and hemoglobin in blood. These herbal extracts recovered the gastric secretion and it gave satisfactory results in vitamin C concentration in gastric juice though the composite extract is more potent than individual in this aspect. This study highlighted the protective activity of these two plants from the hypochlorhydric state. Industrial relevance: Herbal drugs are used for the treatment of different types of gastrointestinal ailments in Ayurveda. Hypochlorhydria is the common problemsof the older people due to aging and also problem of the different aged people due to unnecessary use of anti-secretory drugs. Now a day, hypochlorhydria is controlled by supplementation of betaine-HCl with pepsin, but its excess use can cause irritation in the gastric mucosa. These herbal extracts gave promising results in recovery of the hypochlorhydria without any toxic effect. So, this study would be helpful for the industry to develop herbal formulated standard drug for the treatment of hypochlorhydria.