Miracle-dz/UniFAR-FTUs huggingface dataset:
MRI after treatment of locally advanced rectal cancer: how to report tumor response--the MERCURY experience.

OBJECTIVE The Magnetic Resonance Imaging and Rectal Cancer European Equivalence (MERCURY) Study validated the use of MRI for posttreatment staging and its correlation with survival outcomes. As a consequence, reassessment of MRI scans after preoperative therapy has implications for surgical planning, the timing of surgery, sphincter preservation, deferral of surgery for good responders, and development of further preoperative treatments for radiologically identified poor responders. CONCLUSION In this article we report a validated systematic approach to the interpretation of MR images of patients with rectal cancer after chemoradiation.
Association between neonatal temperament, SLC6A4, DRD4 and a functional polymorphism located in TFAP2B

Genetic studies on human personality have provided little satisfactory results to date mainly because of the complexity of this trait. Neonatal temperament using observational measures is an alternative phenotype to approach genetics to human behavior. An association study was conducted on 117 Caucasian newborns. Their temperament was evaluated using the Neonatal Behavior Assessment Scale 48 h after birth. Thirteen polymorphisms in the SLC6A4, DRD4 and TFAP2B genes were genotyped. Linear regression was performed to analyze data, and Bonferroni correction was applied. To check the functional effect of the TFAP2B Indel Intron 2 polymorphism, reporter gene luciferase assays using a mouse cortical neural progenitor cell line and quantitative polymerase chain reaction (qPCR) studies in human post‐mortem brain samples were performed. A significant association was found between 5‐HTTLPR, 5‐HTTLPR + rs25531 and TFAP2B Indel Intron 2 with Range of State cluster as well as an interaction between rs25531 and TFAP2B Indel Intron 2 with Range of State. DRD4 variable number tandem repeat exon 3 was associated with orientation. A 30% increase in the luciferase levels of the TFAP2B 5‐repeat alleles compared with the 6‐repeat alleles (P‐value = 0.03) was found using the pGL3 promoter vector. The qPCR experiments showed the same trend as the in vitro studies, although no significant results were obtained. This study supports a role of the SLC6A4, DRD4 and TFAP2B genes in the temperament, including a gene–gene interaction between SLC6A4 and TFAP2B. It also provides evidence about an effect of the TFAP2B polymorphism in TFAP2B gene transcription.
Knowledge Sharing of Senior Employees in the Context of Task-Based Cooperation: a Game Theoretic Analysis

The aging of population has become a global trend and the critical knowledge of enterprises may be lost with the retirement of senior employees. Task-based cooperation is an important method to prevent the loss of knowledge and to promote the knowledge sharing behavior between senior employees and young ones. This paper constructs the knowledge contribution payoff functions of senior employees and young ones in the context of task-based cooperation and analyzes the knowledge contribution behavior using static game theory with complete information, and then we obtain Nash equilibrium solutions under different conditions. The results suggest that enterprises can promote knowledge contribution of senior employees and young ones in the process of task-based cooperation by improving social rate of return(e.g., creating a good cultural atmosphere), reducing cost rate of knowledge contribution (e.g., training on knowledge expression), raising economic rate of return and providing monetary compensation according to the contribution of knowledge, whether the marginal payoff of employees’ knowledge contribution is increasing, invariant or diminishing. Since the formation of social return is difficult in the short term, giving economic incentives can be an effective way at the beginning. With the progress of task-based cooperation between senior employees and young ones, the amount of employees’ knowledge (especially of young ones’), the productivity of knowledge contribution, the collaborative efficiency and social rate of return will increase and therefore economic incentives contributing to cooperation between both players may decrease appropriately. The findings of this paper are beneficial to understand knowledge sharing behavior in the context of task-based cooperation, and provide several incentive mechanisms for enterprises to promote knowledge sharing between senior employees and young ones.
Fibronectin, cholesterol and triglycerides ascitic fluid concentration in the prediction of malignancy.

There have been few trials comparing the efficacy of determinations of cholesterol, fibronectin and triglycerides for diagnosis of malignant ascites. In this study we measured these in 200 ascitic fluids from 93 cirrhotic patients (Group A), 47 hepatocellular-carcinoma patients (Group B), 60 extra-hepatic tumour patients (Group C), 44 of them with malignant cells (Group Cpos) and 16 without (Group Cneg). Anova one-way and the Bonferroni test for multiple comparisons showed that fibronectin and cholesterol were significantly higher in the ascitic fluids of patients of group C than of groups A and B (mean +/- ESM) (Cholesterol in A: 27.2 +/- 2.8; in B 23.5 +/- 1.5; in C: 68.6 +/- 5.3 mg/dl. Fibronectin in A: 32.7 +/- 2.8; in B 31.3 +/- 2.6; in C 127.7 +/- 11.1 mg/l). Both were significantly higher in Group Cpos than in Group Cneg (Cholesterol in Cneg: 41.2 +/- 6.7; in Cpos: 78.6 +/- 6.2 mg/dl. Fibronectin in Cneg: 55.0 +/- 11.2; in Cpos 154 +/- 12.3 mg/dl). We found no differences between cirrhotic ascites and malignant ascites due to primary liver hepatocellular-carcinoma. No difference at all in triglycerides were detected. With the Receiver-Operating Characteristic (ROC) curve, cholesterol had the best Youden Index (57%) at a cut-off of 32 mg/dl (sensitivity 78.3%, specificity 79.3% at this level); the best Youden Index (64%) for fibronectin had a cut-off of 60 mg/dl (sensitivity 65%, specificity 89.3%). Triglycerides appeared to be a great deal less effective as a diagnostic marker, with their best Youden Index (23%) at a cut-off 32 mg/dl (sensitivity 66.7%, specificity 56.4%). (ABSTRACT TRUNCATED AT 250 WORDS)
Closed‐Loop Control of Functional Electrical Stimulation‐Assisted Arm‐Free Standing in Individuals With Spinal Cord Injury: A Feasibility Study

Objectives. The purpose of the present study was to show that the design of a neuroprosthesis for unsupported (arm‐free) standing is feasible. We review findings suggesting that a closed‐loop controlled functional electrical stimulation (FES) system should be able to facilitate arm‐free quiet standing in individuals with spinal cord injury (SCI). Particularly, this manuscript identifies: 1) a control strategy that accurately mimics the strategy healthy individuals apply to regulate the ankle joint position during quiet standing and 2) the degrees of freedom (DOF) of the redundant, closed‐chain dynamic system of bipedal stance that have to be regulated to facilitate stable standing.
Epstein-Barr virus-negative precursor B cell lymphoblastic lymphoma after liver transplantation: a unique form of posttransplant lymphoproliferative disease

Background. We report a liver transplant patient with Epstein-Barr virus-negative, precursor B cell lymphoblastic lymphoma diagnosed 6 months after transplantation. Patient. The patient was a 13-year-old boy with acute, fulminant hepatic failure of unknown etiology who underwent cadaveric liver transplantation. Results. Six months after the transplant, the patient developed non-tender cervical lymphadenopathy 2 days after a reduction in prednisone dosage. The adenopathy worsened despite withdrawal of immunosuppression, and a biopsy showed precursor B cell lymphoblastic lymphoma. All investigations for Epstein-Barr virus were negative. The patient responded well to chemotherapy and is currently in complete remission 24 months after diagnosis. Conclusions. Precursor B cell lymphoblastic lymphoma has not been previously reported as a form of posttransplant lymphoproliferative disease. We discuss this unique form of posttransplant lymphoproliferative disease and briefly review the clinical and pathological spectrum of posttransplant lymphoproliferative disease.
BacA Is Essential for Bacteroid Development in Nodules of Galegoid, but not Phaseoloid, Legumes

ABSTRACT BacA is an integral membrane protein, the mutation of which leads to increased resistance to the antimicrobial peptides bleomycin and Bac71-35 and a greater sensitivity to SDS and vancomycin in Rhizobium leguminosarum bv. viciae, R. leguminosarum bv. phaseoli, and Rhizobium etli. The growth of Rhizobium strains on dicarboxylates as a sole carbon source was impaired in bacA mutants but was overcome by elevating the calcium level. While bacA mutants elicited indeterminate nodule formation on peas, which belong to the galegoid tribe of legumes, bacteria lysed after release from infection threads and mature bacteroids were not formed. Microarray analysis revealed almost no change in a bacA mutant of R. leguminosarum bv. viciae in free-living culture. In contrast, 45 genes were more-than 3-fold upregulated in a bacA mutant isolated from pea nodules. Almost half of these genes code for cell membrane components, suggesting that BacA is crucial to alterations that occur in the cell envelope during bacteroid development. In stark contrast, bacA mutants of R. leguminosarum bv. phaseoli and R. etli elicited the formation of normal determinate nodules on their bean host, which belongs to the phaseoloid tribe of legumes. Bacteroids from these nodules were indistinguishable from the wild type in morphology and nitrogen fixation. Thus, while bacA mutants of bacteria that infect galegoid or phaseoloid legumes have similar phenotypes in free-living culture, BacA is essential only for bacteroid development in indeterminate galegoid nodules.
Quantitation of 5HT2A receptor mRNA in human postmortem brain using competitive RT‐PCR

WE describe quantitation of the absolute amounts of 5HT2A receptor mRNA in various areas of human postmortem brain using a very sensitive and specific technique: competitive reverse transcription polymerase chain reaction (RT-PCR). With this procedure, we were able to show that the highest levels of 5HT2A receptor mRNA are in cerebral cortical areas, i. e. , Brodmann's areas 8, 9, 10, 18, 19, 22, 24, and 46, and that intermediate levels occur in the hippocampus, the amygdala, the nucleus accumbens, and the hypothalamus. Very low levels of 5HT2A receptor mRNA were found in the cerebellum, the thalamus, the caudate, and the putamen. Our results confirm the heterogeneous distribution of 5HT2A receptor mRNA in human postmortem brain and suggest that competitive RT-PCR is a highly sensitive and specific procedure for the quantitative measurement of 5HT2A receptor mRNA expression. The study of 5HT2A receptor mRNA in different brain areas will help clarify the regulation of 5HT2A receptors at the transcriptional level in various neuropsychiatric diseases.
Respiratory pattern, thoracoabdominal motion and ventilation in chronic airway obstruction.

BACKGROUND Patients with chronic obstructive pulmonary disease (COPD) present abnormal respiratory mechanics, but its relation to ventilation variables at rest is not fully understood. METHODS We evaluated breathing pattern, thoracoabdominal motion, and ventilation in moderate and severe COPD patients by means of respiratory inductive plethysmograph and analysis of respiratory metabolism in semirecumbent position at rest. Diaphragmatic movement was measured using radiographs. RESULTS COPD patients showed an increase in mean inspiratory flow, minute ventilation, dead space ventilation, oxygen and carbon dioxide ventilatory equivalents and reduction of respiratory times and pulse oxymetry. These findings were more pronounced in severe COPD. Changes in ventilatory efficiency were correlated with decreased respiratory times, reduced diaphragmatic movement, and lower oxygen uptake. CONCLUSIONS Rapid shallow breathing and reduced diaphragmatic movement have led to ventilatory inefficiency without changes in thoracoabdominal motion.
Negative thermal expansion of diamond and zinc-blende semiconductors.

Experimentally it is well known that diamond and zinc-blend semiconductors show an «unusual» (i.e., negative) thermal expansion at about 100 K. We performed density-functional-theory calculations of thermodynamic potentials (i.e., total energies and entropies) for perfect crystals, to study the temperature dependence of the lattice parameter. The origin of the negative expansion effect is traced back to the entropy contribution of the Gibbs free energy
Treatment of allergic asthma by targeting janus kinase 3-dependent leukotriene synthesis in mast cells with 4-(3', 5'-dibromo-4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline (WHI-P97).

4-(3',5'-Dibromo-4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline (WHI-P97) is a rationally designed potent inhibitor of Janus kinase (JAK)-3. Treatment of mast cells with WHI-P97 inhibited the translocation of 5-lipoxygenase (5-LO) from the nucleoplasm to the nuclear membrane and consequently 5-LO-dependent leukotriene (LT) synthesis after IgE receptor/FcepsilonRI crosslinking by >90% at low micromolar concentrations. WHI-P97 did not directly inhibit the enzymatic activity of 5-LO, but prevented its translocation to the nuclear membrane without affecting the requisite calcium signal. WHI-P97 was very well tolerated in mice, with no signs of toxicity at dose levels ranging from 5 microg/kg to 50 mg/kg, and LD(10) was not reached at a 50 mg/kg dose level when administered as a single i. p. or i.v. bolus dose. Therapeutic WHI-P97 concentrations, which inhibit mast cell leukotriene synthesis in vitro, could easily be achieved in vivo after the i.v. or i.p. administration of a single nontoxic 40 mg/kg bolus dose of WHI-P97. Notably, WHI-P97 showed promising biological activity in a mouse model of allergic asthma at nontoxic dose levels. Treatment of ovalbumin-sensitized mice with WHI-P97 prevented the development of airway hyper-responsiveness to methacholine in a dose-dependent fashion. Furthermore, WHI-P97 inhibited the eosinophil recruitment to the airway lumen after the ovalbumin challenge in a dose-dependent fashion. Further development of WHI-P97 may therefore provide the basis for new and effective treatment as well as prevention programs for allergic asthma in clinical settings.
Barriers and Enablers to Treatment-Seeking Behavior and Causes of High-Risk Practices in Ebola: A Case Study From Sierra Leone

Nine months after the start of the Ebola outbreak in Sierra Leone in May 2014, communities in Port Loko continued to engage in high-risk practices; many remained unwilling to seek treatment. In the face of such behaviors, Oxfam Community Outreach teams conducted qualitative research using in-depth interviews, focus groups, and questionnaires to better understand the barriers and enablers affecting treatment-seeking behavior. Analysis of their results highlights 3 primary barriers to treatment seeking: fear and limited information, concern about unknown outsiders, and the often prohibitive distance and limited accessibility of treatment. Communities were asked to provide suggestions on how to address these barriers. Their recommendations fell into 4 main categories: providing information and better communication, including community members in decisions, providing closer treatment facilities with opportunities to learn how they operate, and using survivors to inspire hope for other sufferers. This research highlights the need for social mobilization programs to invest early in understanding the underlying causes of risky behaviors in order to develop programs that address them.
Block of sodium current by heptanol in voltage-clamped canine cardiac Purkinje cells.

Heptanol blocks sodium current (INa) in nerve, but its effects on cardiac INa have not been well characterized. Block of INa by heptanol was studied in 16 internally perfused voltage-clamped cardiac Purkinje cells at reduced Na+ (45 mM outside, 0 mM inside). Heptanol block of peak sodium conductance was well described by a single-site binding curve with half block at 1.3 mM (20 degrees C) and showed no "use dependence. " With 1.5 mM heptanol, block increased slightly by 0.7%/degrees C from 10 degrees C to 27 degrees C. With 3.0 mM heptanol, steady-state availability shifted by 9.4 +/- 1.3 mV (n = 6) in the hyperpolarizing direction, and steady-state activation shifted by 8.3 +/- 2.2 mV (n = 5) in the depolarizing direction, thus closing off the INa "window current. " Heptanol also decreased the time to peak and accelerated the decay of INa. Similar results were found with octanol at lower concentrations. These alcohols have important effects on cardiac INa at concentrations used in studies for cellular uncoupling in heart.
Methylenetetrahydrofolate Reductase Polymorphisms and Susceptibility to Acute Lymphoblastic Leukemia in a Chinese Population: A Meta-Analysis

SummaryBackground: Although many epidemiologic studies have investigated the methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and their association with acute lymphoblastic leukemia (ALL), definitive conclusions cannot be drawn. To clarify the effects of MTHFR polymorphisms on the risk of ALL, a meta-analysis was performed in a Chinese population. Materials and Methods: A computerized literature search was carried out in PubMed, the Chinese Biomedicine (CBM) database, China National Knowledge Infrastructure (CNKI) platform, and the Wanfang database (Chinese) to collect relevant articles. Results: A total of 11 articles including 1,738 ALL cases and 2,438 controls were included in this meta-analysis. Overall, a significantly decreased association was found between the MTHFR C677T polymorphism and ALL risk when all studies in Chinese populations were pooled into the meta-analysis. In subgroup analyses stratified by age, ethnicity, and source of controls, the same results were observed in children, in population-based studies, and in people with no stated ethnicity. However, a significantly increased association was also found for MTHFR C677T in hospital-based studies, and for MTHFR A1298C in people with no stated ethnicity. Conclusion: Our results suggest that the MTHFR C677T and A1298C polymorphisms may be potential biomarkers for ALL risk in Chinese populations, and studies with a larger sample size and wider population spectrum are required before definitive conclusions can be drawn.
Hydrophobicity of amino acid subgroups in proteins

Protein folding studies often utilize areas and volumes to assess the hydrophobic contribution to conformational free energy (Richards, F. M. Annu. Rev. Biophys. Bioeng. 6:151–176, 1977). We have calculated the mean area buried upon folding for every chemical group in each residue within a set of X‐ray elucidated proteins. These measurements, together with a standard state cavity size for each group, are documented in a table. It is observed that, on average, each type of group buries a constant fraction of its standard state area. The mean area buried by most, though not all, groups can be closely approximated by summing contributions from three characteristic parameters corresponding to three atom types: (1) carbon or sulfur, which turn out to be 86% buried, on average; (2) neutral oxygen or nitrogen, which are 40% buried, on average; and (3) charged oxygen or nitrogen, which are 32% buried, on average.
Determination of sex by cone-beam computed tomography analysis of mental foramen in South Indian Population

Background: One of the most challenging tasks for forensic dentists and anthropologists has been identification and determination of sex of unknown human skeletal remains. Aim: To determine sexual dimorphism by CBCT (3-D) analysis of mental foramen among the south Indian population. Materials and Methods: Total of 116 CBCT images of subjects were analysed. Distance from the superior border of mental foramen to lower border of mandible (SLM) and the inferior border of mental foramen to lower border of mandible (ILM) were calculated by three examiners and recorded. Statistical Analysis: Descriptive statistics, paired t-test and independent sample t-test were used for statistical comparisons. Results: The mean distance of right SLM among male and female subjects were 17.07±1.64 and 14.92 ± 1.33 respectively. Similarly of the left side of male and female subjects were 13.30 ±1.52 and 11.73± 1. The mean distance of left ILM among male and female subjects were 13.44± 1.68 and 11.79 ± 1.21 respectively and on the left side of male and female subjects were 1.3 ± 1.52 and 11.73 ± 1.27. There was a statistically significant difference between sex and sides in terms of SLM and ILM (P = 0.0001). Conclusion: Distances from mental foramen to the lower border of mandible demonstrates sexual dimorphism.
A robust frequency offset estimation scheme for OFDM systems

In this paper, an improved carrier frequency offset estimation method which is less sensitive to timing offset is proposed. The method is based on the carefully constructed frequency domain sequence and the correlation operation. Then, we analyze the performances of our newly proposed estimation metric over different wireless channel conditions by Monte Carlo simulations. Finally, according to the training symbols of IEEE 802.16d, our simulation results show that the newly proposed method can overcome the relatively large influences introduced by timing offset, and at the same time, it may perform better than the conventional methods without increasing algorithm's complexity.
Prediction of postdialysis hypophosphataemia.

Hypercalcaemia is a well-recognised, potentially lethal complication of certain non-endocrine neoplasms but rarely occurs in leukaemia. This is especially true in the case of chronic granulocytic leukaemia (CGL), few such instances having been reported. '-We therefore describe three patients with CGL who developed hypercalcaemia while in the accelerated phase of the disease. Two also had complicating encephalopathy.
Factor structure of the Impact of Event Scale‐Revised in two different Peruvian samples

Background: This article studied the factor structure of the Impact of Event Scale‐Revised (IES‐R) in two samples in Peru, i.e., a sample of survivors of a fire (N=174) and a university student sample (N=562). Methods: First, confirmatory factor analysis was used to compare nine different models of posttraumatic stress disorder symptoms as evaluated by the IES‐R in both of the samples separately. The model with the best fit in both samples had four correlated factors, i.e., Intrusion, Avoidance, Hyperarousal and Sleep Disturbance. Second, the degree of factorial invariance of the IES‐R was compared in both the samples using multiple group confirmatory factor analysis. Results and Conclusions: The results showed almost no differences between both samples. Finally, the results supported the internal consistency, as well as the concurrent and convergent validity of the IES‐R in Peru. Depression and Anxiety, 2009. © 2009 Wiley‐Liss, Inc.