Miracle-dz/UniFAR-FTUs huggingface dataset:
TIME-KILL ASSAY: AN EFFICACY OF SYNERGY BETWEEN CARBAPENEMS AND CLODRONIC ACID

Currently, a search for augmenting antibiotics activity is still crucial due to elevated frequency of detecting carbapenem-resistant Gran-positive bacterial isolates. To resolve this, it might be reasonable to combine carbapenems metal-β-lactamase (MβL) inhibitors. Unfortunately, no MβL inhibitors approved for treatment of carbapenem-resistant infections are currently available. Pathogenic bacteria may survive antibiotic attack, exert tolerance and persistence accompanied with the ongoing infectious process. In connection with this, determining dependence between antimicrobialrelated bactericidal effect and exposure time on microbes at 4, 8, 12 and 24 hours after the onset, a so called time-kill assay, is necessary. A synergy between both agents was noted upon reduced microbial population by ≥ 3 log10. A checkerboard array followed by seeding the microplate well contents onto a dense nutrient medium at various time points were used to assess a synergistic efficacy of carbapenems applied together with clodronic acid against MβL-producing VIMgenotype P. aeruginosa 532/14 clinical isolate obtained from patients with infectious complications (minimal inhibitory concentrations [MIC] for imipenem or meropenem were 512 μg/ml), microbial burden 10 CFU/ml. Optical density was measured at two wavelengths (490 and 630 nm) in ELx800 reader, within 4–24 hour exposure time to determine time of logarithmic growth phase emerging in test culture. It is noteworthy that magnitude of optical density is a difference between two bichromatic measurements resulting in remarkably reduced inaccuracy due to scratches or fingerprints left on the plate. It was found that clodronic acid exhibited a synergic bactericidal effect with carbapenems against a clinically resistant MβL-producing VIM-genotype P. aeruginosa 532/14 strain. Upon that, imipenem-related antimicrobial activity was evident as early as 8 hours after the onset decreasing cell growth down to 1.4 log10 compared to control, whereas 12 hours later it resulted in total inhibition of test strain by decreasing growth of the test strain by 6 log10. Meropenem in combination with clodronic acid showed a more pronounced activity: complete absence of P. aeruginosa 532/14 growth by 8 hours of incubation, growth suppression by 3.2 log10, which reached 6 log10 12–24 hours after the onset. Time-kill assay allows to identify efficient combinations of carbapenems and MβL inhibitors, which is of great importance for increasing therapeutic efficacy of patients with severe purulent-septic complications.
AMEP_A_222779 897..905

Saeed Babajani-Vafsi Jamileh Mokhtari Nouri Abbas Ebadi Mitra Zolfaghari 1Nursing Management Department, Faculty of Nursing, Baqiyatallah University of Medical Sciences, Tehran, Iran; 2Medicine, Quran and Hadith Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran; 3Behavioral Sciences Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran; 4Nursing and Midwifery Care Research Center, Department of Electronic Learning in Medical Sciences, Virtual School, Tehran University of Medical Sciences, Tehran, Iran Introduction: The emergence of mobile instant messaging (MIM) based virtual communities of practice (VCoPs) has provided new opportunities for nurses to share their knowledge and promote collaborative learning. This study was conducted with the aim of exploring the factors influencing nurses’ participation in knowledge-sharing within MIM-based VCoPs. Material and methods: This is a qualitative study conducted in Tehran, Iran, between April 2017 and July 2018. The participants were 18 nurses that selected through purposeful sampling technique; then, in-depth and semi-structured interviews were conducted with them. Data was analyzed using conventional content analysis based on Graneheim and Lundman (2004). Accordingly, all interviews were transcribed and read several times; then, meaning units were identified from the transcribed text based on the aim of the study and codes were extracted from them. Finally, the codes were classified into categories and themes. Results: A total of 26 sub-categories, seven categories, and two themes were extracted. Motivations for nurses’ participating in knowledge-sharing activities within MIM-based VCoPs included the theme “Stimuli for professional interactions” with three categories: “The individual drives”, “Attractive interactive environment”, and “User-friendly media”. On the other hand, participation barriers included the theme “Impediments for professional interactions” with four categories of “Individual hindrances”, “Social harm”, “Unprofessional interactive environment” and “Undesirable media”. Conclusion: The findings of this exploratory study indicated that individual, social and technological factors as well as factors associated with the virtual-community interactive environment could influence nurses’ participation in knowledge-sharing within MIM-based VcoPs as motivations and barriers. The insights obtained from this study can be a guide for administrators and educators in the nursing profession to facilitate and enhance nurses’ participation in knowledge-sharing within MIM-based VCoPs by strengthening motivations and minimizing barriers.
Operational Practices and Performance: An Empirical Analysis of Brazilian Manufacturing Companies

This paper used the SEADE database on 1,200 manufacturing companies, located in São Paulo state, active in 14 different industries, to test the relationship between certain operational practices, such as quality, just in time, ISO certifications and level of outsourcing with organizations’ performance. The study used a multiple regression technique and performance was measured in terms of Profitability and Revenue Growth Rate. Generally, no relationship between these practices and performance could be found. The findings were unable to support the large body of literature in operations management that establishes this link based on anecdotal evidence. Level of outsourcing was the only consistently related variable, negatively related with both profitability and growth.
The Influence of Affective Empathy and Autism Spectrum Traits on Empathic Accuracy

Autism spectrum disorder is characterized by interpersonal deficits and has been associated with limited cognitive empathy, which includes perspective taking, theory of mind, and empathic accuracy (EA). The capacity for affective empathy may also be impaired. In the present study we aimed to determine if EA in normally developing individuals with varying levels of autism spectrum traits is moderated by trait affective empathy. Fifty male and fifty female participants (‘perceivers’) completed the Autism-Spectrum Quotient and the Balanced Emotional Empathy Scale to assess autism spectrum traits and trait affective empathy, respectively. EA was assessed using a Dutch-language version of a previously developed task and involved rating the feelings of others (‘targets’) verbally recounting autobiographical emotional events. Targets varied in trait emotional expressivity, assessed using the Berkeley Expressivity Questionnaire. Perceivers with more autism spectrum traits performed worse on the EA task, particularly when their trait affective empathy was relatively low. Interpersonal deficits in autism spectrum disorder may be partially explained by low cognitive empathy. Further, they might be aggravated by a limited capacity for affective empathy. Citation: aan het Rot M, Hogenelst K (2014) The Influence of Affective Empathy and Autism Spectrum Traits on Empathic Accuracy. PLoS ONE 9(6): e98436. doi:10.1371/journal.pone. 0098436 Editor: Angela Sirigu, French National Centre for Scientific Research, France Received October 3, 2013; Accepted May 4, 2014; Published June 6, 2014 Copyright: 2014 aan het Rot, Hogenelst. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: The work was supported by the Innovational Research Incentives Scheme Veni from the Netherlands Organisation for Scientific Research (NWO, Veni grant 451-09-013 awarded to Dr. aan het Rot). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: The authors have declared that no competing interests exist. * E-mail: m.aan. het.rot@rug.nl
Vietnam Trade Balance and Exchange Rate: Evidence from Panel Data Analysis

This study attempts to examine the effect of real exchange rate, domestic and foreign income on bilateral trade balance for Vietnam and her sixteen trading partners over the period 1999-2012. This study for the first time applies the most recently developed panel co-integration method to examine the long-run relationship between the real exchange rate and bilateral trade. The null hypothesis of no co-integration is rejected in all tests, implying that there is a long-run relationship between trade balance, real exchange rate, domestic income, and foreign income in the case of Vietnam. The results from both panel FMOLS and DOLS estimation show that, overall, the real exchange rate and domestic income have negative effect on trade balance, whereas foreign income reported positive effect on trade balance. All variables are in expected sign and statistically significant. A policy implication from this study is that Vietnam’s trade balance can be improved by restructuring the economy rather than devaluating currency in the long run.
CONHECIMENTO DO PROFISSIONAL ENFERMEIRO SOBRE ILEOSTOMIA, NA ATENÇÃO BÁSICA KNOWLEDGE OF PROFESSIONAL NURSING ON ILEOSTOMY, IN PRIMARY CARE EL CONOCIMIENTO DE LA ENFERMERÍA PROFESIONAL EN LA ILEOSTOMÍA, EN ATENCIÓN PRIMARIA

This was an exploratory study with a qualitative approach that aimed to identify the knowledge of nurses on ileostomy of Family Health Teams (FHT) of the Health District of Uberaba that described the perception of nurses on the nursing care with definitive stoma patient. After approval from the Research Ethics Committee, data were collected with 16 nurses, through semi-structured interviews. Thematic content analysis proposed by Bardin was used. Most were female (93.75%), single (56.25%), with 1 to 5 years of study in nursing and had worked in the FHT 1-5 years. The age range was 25 to 45 years. In the data analysis revealed three categories: proper knowledge, inadequate or absent in relation to its possible complications ileostomy care and approach to patients with definitive stoma. One must consider that from the knowledge received by nurses in undergraduate and / or professional practice, enables the development of actions aimed at efforts to improve the quality of life of these patients, as well as empowering professionals assistance to perform actions based on scientific knowledge, against the backdrop of the specialized assistance and systematized.
OCCURRENCE OF BOVINE MASTITIS AND ISOLATION OF SPECIES FROM FRESH COW MILK IN SETTLED FULANI HERDS IN KADUNA STATE,

A study was conducted on 360 dairy cows (1440 quarters) to determine the prevalence of mastitis by California Mastitis Test (CMT) and Staphylococci in settled Fulani herds in Kaduna State, Nigeria. The prevalence of mastitis at cow level was 26.9% (97/360) and out of which 23.9% (86/360) and 3.1% (11/360) were subclinical mastitis and clinical mastitis respectively. The prevale quarter level was 21.7% (312/1440), and out of which 6.5% (28/1440) was clinical mastitis and 19.7% (284/1440) was subclinical mastitis respectively. Statistical analysis showed that there was significant difference in the occurrence of mastitis amo at quarter level was 25.2% (157/624) in adult cows, 20.2% (97/480) in young adults and 17.3% (58/336) in old cows. Similar pattern of occurrence was recorded for both clinical and subclinical mastitis as the adults had 21.8% and 3.4 %, young adults had 19.8% and 0.4% and old cows had 15.8% and 1.5% respectively. The CMT scores showed that 55 (64.0%) of the milk samples had a score of 1+, 26 (30.2%) had a score of 2+, 3 (3.5) had a score of 3+ while only 2 (2.3%) had score of “Trace”. Sixty seven (69.1%) of the samples that were positive for CMT were found to be culture positive and out of which 56.7% (55/97) were S. aureus and 12.3% (12/97) were coagulase-negative staphylococci (CONS). The high prevalence of both c mastitis coupled with the isolation of S. aureus and CONS are of great public health concern and requires strict control and preventive measures. The study recommends standards hygienic measures during milking and culling of infecte cows.
The Entrepreneurship Enabling Role of Freelancers: Theory with Evidence from the Construction Industry

In the entrepreneurship literature freelance workers are often categorised as a small and underperforming version of entrepreneurial owner managers. By contrast, in the industrial relations literature they are often depicted as a form of exploited worker. In this paper we explore the overlooked contextual entrepreneurial function of freelancers where they are the enablers of entrepreneurship rather than the entrepreneurial agents themselves. We outline some key hypotheses and test them in the construction industry where freelancers supply routine labour. We show that freelancers play a key role in their own right in enabling entrepreneurial performance by facilitating the use of de-risking strategies, reducing financial constraints, increasing entrepreneurial strategic agility as well as facilitating market entry by start-ups. This paper is a first but important step towards facilitating a new research trajectory focusing on the contextual role of freelancers in the entrepreneurial economy.
Haemato-biochemical studies in cystic endometrial hyperplasia pyometra complex in Canine

In the present study, an attempt was made to correlate haematological and biochemical data with pathological changes from bitches affected with cystic endometrial hyperplasia pyometra complex (CEHPC). Total leucocyte (TLC), differential leucocyte count (DLC), total erythrocyte count (TEC) and haemoglobin (Hb) concentration were determined for haematology and as biochemical parameters blood urea nitrogen (BUN) and plasma creatinine were estimated to assess the renal dysfunction. Total plasma protein (TPP) was also determined in the pyometric bitches. Haematology of CEHPC cases showed leucocytosis, neutrophilia, lymphocytopenia and anemia. Biochemically, the increased BUN and hyperproteinemia were observed but the plasma creatinine values were not very much affected. Alterations in the haematological and biochemical parameters were more marked in cases where the cervix was closed.
Company life cycle models and business valuation

Future free cash flow is a crucial element of most business valuation tools, such as the Discounted Cash Flow model, with the quality of the valuation depending heavily on its forecast accuracy. This paper explores the theory on business life cycle (and growth) models in an aim to improve that quality. Life cycle and growth models have been studied in the management and organization literature for decades, but the relevant aspects from a business valuation perspective remain unclear. Reviewing the existing literature, we argue that the five-stage Hanks model (Start-up, Growth, Maturity, Diversification, and Decline) is applicable for valuation purposes. We further argue that life cycle thinking provides useful insights for making grounded assumptions in predicting the future free cash flows and residual value of a company. This paper presents practical valuation approaches and insights for each of the five stages of the Hanks model.
Global Journal of Researches in Engineering

A method is presented for elaboration parameters of seismic action on the territory of Tbilisi region. This study has taken into account stochastic nature of earthquakes. Some steps are considered to generate a synthetic ground motion accelerogram compatible with a response spectrum. A mathematical model to simulate ground motion processes is proposed for which both intensity and frequency content are non-stationary. The simulated time histories fit the recorded accelerograms in terms of several ground-motion amplitude measures, such as Peak Acceleration, Fourier Spectra and Response spectra. The method consists in correlating the simulation parameters with earthquake magnitude, source distance and soil conditions. Keywords-Ground, Motion, Seismic, Stochastic, Accelerogram
Unsupervised Graph Association for Person Re-Identification

In this paper, we propose an unsupervised graph association (UGA) framework to learn the underlying viewinvariant representations from the video pedestrian tracklets. The core points of UGA are mining the underlying cross-view associations and reducing the damage of noise associations. To this end, UGA is adopts a two-stage training strategy: (1) intra-camera learning stage and (2) intercamera learning stage. The former learns the intra-camera representation for each camera. While the latter builds a cross-view graph (CVG) to associate different cameras. By doing this, we can learn view-invariant representation for all person. Extensive experiments and ablation studies on seven re-id datasets demonstrate the superiority of the proposed UGA over most state-of-the-art unsupervised and domain adaptation re-id methods.
DANet: Divergent Activation for Weakly Supervised Object Localization

Weakly supervised object localization remains a challenge when learning object localization models from image category labels. Optimizing image classification tends to activate object parts and ignore the full object extent, while expanding object parts into full object extent could deteriorate the performance of image classification. In this paper, we propose a divergent activation (DA) approach, and target at learning complementary and discriminative visual patterns for image classification and weakly supervised object localization from the perspective of discrepancy. To this end, we design hierarchical divergent activation (HDA), which leverages the semantic discrepancy to spread feature activation, implicitly. We also propose discrepant divergent activation (DDA), which pursues object extent by learning mutually exclusive visual patterns, explicitly. Deep networks implemented with HDA and DDA, referred to as DANets, diverge and fuse discrepant yet discriminative features for image classification and object localization in an end-to-end manner. Experiments validate that DANets advance the performance of object localization while maintaining high performance of image classification on CUB-200 and ILSVRC datasets
Cognition enhancing effect of panax ginseng in Korean volunteers with mild cognitive impairment: a randomized, double-blind, placebo-controlled clinical trial

This study aimed to investigate the cognition-enhancing effect of Panax ginseng. A randomized, double-blind, placebo-controlled clinical trial was conducted to address the cognition-enhancing effects of Panax ginseng. A total of 90 Korean volunteers with mild cognitive impairment participated in this study. All subjects were allocated randomly into ‘Ginseng’ group or ‘Placebo’ group. All subjects were administered 3g of Panax ginseng powder or starch (placebo) for 6 months. The Korean version of the Mini-Mental Status Examination (K-MMSE), Korean version of Instrumental Activities of Daily Living (K-IADL), and Seoul Neuropsychological Screening Battery (SNSB) were used to assess the changes in cognitive function at the end of the 6 month study period. The subjects of the ‘Ginseng’ group improved significantly on the Rey Complex Figure Test (RCFT) immediate recall (P = 0.0405 and P = 0.0342 in per-protocol (PP) and intention-to-treat (ITT) analysis, respectively) and on the RCFT 20-min delayed recall (P = 0.0396 and P = 0.0355 in PP and ITT analysis, respectively) compared with ‘placebo’ group throughout the 6 months of Panax ginseng administration. There were no serious adverse events. These results suggest that Panax ginseng has a cognition-enhancing effect.
1 The monoclonal antibody recognized apoptosis-2 associated protein in PCV 2-infected peripheral blood 3 mononuclear cells 4

Porcine circovirus type 2 (PCV2) is a small non-enveloped DNA virus that causes swine immunosuppression by inducing apoptosis in lymphocytes. The ORF3 protein plays a major role in PCV2-induced apoptosis in porcine kidney cells, but there is little information regarding this protein in PCV2-infected lymphocytes. In this study, hybridoma screening and epitope mapping were determined by using an indirect ELISA. The mAb 7D3 against ORF3 peptide (residues 35–65) of PCV2 were generated in this study. In vivo situation, the mAb 7D3 recognized ORF3 protein existed in PCV2-infected apoptotic porcine PBMCs. It is noteworthy that thimerosal interfered with the binding of mAb 7D3 to epitope and it was diminished by adding cysteine. Additionally, thimerosal interacting with cysteine-containing peptide was demonstrated by the PTI assay. Furthermore, thimerosal specifically interacted with the antigen-binding sites of mAb 7D3. This study suggested that thimerosal blockade the occlusion of the antigen-binding sites of mAb 7D3 to bind ORF3 peptide (residues 35–65) via thimerosal interacting with cysteine residues which should be located within the antigen-binding sites of mAb 7D3. Overall, the mAb 7D3 has been characterized and it will be a valuables tool in future studies of ORF3 function and the wider mechanism of cell apoptosis caused by PCV2 infection. Similarly, these techniques will be useful for applications in detecting thimerosal too.
Relationship Between Academic Achievement and Miranda Rights Comprehension and False Confessions A Thesis Submitted to the Faculty

vii 1. BACKGROUND AND LITERATURE SURVEY 1 1.1 The Miranda Warning.2 1.2 Applicability of Miranda Rights to Juvenile Court.3 1.3 Conducting Miranda Evaluations.5 1.4 Updating the Miranda Instruments . 7 1.5 Research on Juveniles’ Miranda Comprehension.8 1.6 IQ and Miranda Comprehension Research . 11 1.7 Educational Achievement and Miranda Comprehension.12 1.8 Research on Juveniles and False Confessions.14 1.9 Intelligence and False Confessions . 15 1.10 Educational Achievement and False Confessions.16 1.11 Special Education and Miranda Comprehension.17 1.12 Special Education and False Consfessions.18
Air Pollution and the Labor Market: Evidence from Wildfire Smoke

We study how air pollution impacts the U.S. labor market by analyzing the effects of drifting wildfire smoke. We link satellite-based smoke plume data with labor market outcomes to estimate that an additional day of smoke exposure reduces quarterly earnings by about 0.1 percent. Extensive margin responses, including employment reductions and labor force exits, explain 13 percent of the overall earnings losses. The implied welfare costs from lost earnings due to air pollution exposure is on par with standard valuations of the mortality burden. The findings highlight the importance of labor market channels in air pollution policy responses.
Examining the Relationship between the Co-Creation and Co-Innovation Success in Tourism and Hotel Industry

The objective of this study is to examine the relationship between co-creation and co-innovation in the tourism and hospitality industry. It also investigates the influence of employees working experiences on co-creation and co-innovation success. Data were collected by developed questionnaire. Originally, 420 questionnaires were distributed to hotels and travel agencies employees in Cairo and Alexandria. Only 395 of the questionnaires were valid giving a response rate of 94%. Data were statistically analyzed using factor analysis, correlation and regression analysis. The results indicated that co-creation is positively related to the co-innovation process. Also, it was found that employees working experiences are significantly related to co-creation and co-innovation success.