Miracle-dz/UniFAR-FTUs huggingface dataset:
The Association between Callous-Unemotional Traits and Emotional Processing Within Individuals and Across Generations

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The Relationship of Blood Pressure and Cortisol Reactivity to Family History of Hypertension of African American Adolescents

&NA; Ethnicity and family history of hypertension (FHH) have been associated with the development of hypertension. Blood pressure and cortisol reactivity during physiologic stress are hypothesized to function as biologic markers for hypertension. The purpose of this study was to explore the relationship of blood pressure and cortisol reactivity physiologic to FHH in a selected sample of African American adolescents. Methods: Demographic data and physiologic measurements were obtained from 48 African American adolescents (14-17 years). Reactivity was induced by a cold pressor test of hand immersion in cold water. &khgr;2, t tests, and multivariate repeated-measures analysis were used to determine relationships. Results: Thirty-one (65%) subjects reported an FHH. Thirty (63%) subjects demonstrated cardiovascular reactivity. Although the mean systolic blood pressure was 4 mm Hg higher, t tests indicated no significance between group in systolic blood pressure (P = .32), diastolic pressure (P = .73), and cortisol (P =.81). Blood pressure reactivity of the FHH group was significantly different than the no family history group (P = .0338). Cortisol levels for the total group were markedly elevated (19 nmol/dL) and there was no significant difference in reactivity. Conclusion: African American adolescents with FHH demonstrate increased blood pressure reactivity. Cortisol levels were elevated for all participants. This study adds support to the association of blood pressure reactivity, a biologic marker of HTN and FHH.
Binding competition of toxic shock syndrome toxin 1 and other staphylococcal exoproteins for receptors on human peripheral blood mononuclear cells

Binding of toxic shock toxin 1 (TSST-1) and staphylococcal enterotoxin A (SEA) to human peripheral blood mononuclear cells (PBMC) was investigated by using 125I-labeled ligands. Scatchard analyses revealed similar numbers of receptors (approximately 5,000 to 8,000) and similar dissociation constants (Kd, approximately 20 to 25 nM) per PBMC. SEA but not enterotoxin B, C1, C2, C3, D, or E significantly inhibited binding of 125I-TSST-1 to PBMC. Cross-competition of TSST-1 and SEA in binding assays suggests that they may bind to overlapping or separate epitopes on the same receptor.
Enhancing the Capacity of Spectrum Sharing Cognitive Radio Networks

Spectrum sharing has attracted a lot of attention in cognitive radio recently as an effective method of alleviating the spectrum scarcity problem by allowing unlicensed users to coexist with licensed users under the condition of protecting the latter from harmful interference. In this paper, we focus on the throughput maximization of spectrum sharing cognitive radio networks and propose a novel cognitive radio system that significantly improves their achievable throughput. More specifically, we introduce a novel receiver and frame structure for spectrum sharing cognitive radio networks and study the problem of deriving the optimal power allocation strategy that maximizes the ergodic capacity of the proposed cognitive radio system under average transmit and interference power constraints. In addition, we study the outage capacity of the proposed cognitive radio system under various constraints that include average transmit and interference power constraints, and peak interference power constraints. Finally, we provide simulation results, in order to demonstrate the improved ergodic and outage throughput achieved by the proposed cognitive radio system compared to conventional spectrum sharing cognitive radio systems.
Seuils d'efficacité de la sélection en C.E.S. chez Hevea brasiliensis

Grâce aux donnees de croissance et de production recueillies ou calculees en champs d'evaluation des seedlings (CES), premier stade de selection, et en champs de clones a petite echelle (CCPE), deuxieme stade de selection, on a pu examiner les valeurs agronomiques des familles, etudier les relations entre variables du CES et celles du CCPE par le biais des correlations et des regressions lineaires. Ensuite, les performances des clones elites en CCPE ont permis de rechercher les seuils d'efficacite de la selection en CES, de par la situation de ces genotypes dans le plan des seuils prealablement etablis a partir de l'analyse en composantes principales effectuee en CES. Enfin connaissant les niveaux de correlations CES-CCPE, l'intensite de selection en CES et la proportion de clones elites attendus en CCPE, des seuils de selection ont ete recherches par simulation suivant une methode proposee par N.W. Simmonds 1985. Lorsque le niveau de correlation est faible (r plus petit que 0,40 dans le cas de cette experimentation), la selection devient assimilable a un simple tirage au hasard. Avec un coefficient de correlation hautement significatif (r=0,40), l'ecart de la selection par rapport au tirage aleatoire est de 10%. Cet ecart s'accentue en faveur de la selection au fur et a mesure que les coefficients deviennent de plus en plus eleves et hautement significatifs [resume d'auteur]
Reported provision of analgesia to patients with acute abdominal pain in Canadian paediatric emergency departments.

OBJECTIVES Evidence exists that analgesics are underutilized, delayed, and insufficiently dosed for emergency department (ED) patients with acute abdominal pain. For physicians practicing in a Canadian paediatric ED setting, we (1) explored theoretical practice variation in the provision of analgesia to children with acute abdominal pain; (2) identified reasons for withholding analgesia; and (3) evaluated the relationship between providing analgesia and surgical consultation. METHODS Physician members of Paediatric Emergency Research Canada (PERC) were prospectively surveyed and presented with three scenarios of undifferentiated acute abdominal pain to assess management. A modified Dillman's Tailored Design method was used to distribute the survey from June to July 2014. RESULTS Overall response rate was 74.5% (149/200); 51.7% of respondents were female and mean age was 44 (SD 8.4) years. The reported rates of providing analgesia for case scenarios representative of renal colic, appendicitis, and intussusception, were 100%, 92.1%, and 83.4%, respectively, while rates of providing intravenous opioids were 85.2%, 58.6%, and 12.4%, respectively. In all 60 responses where the respondent indicated they would obtain a surgical consultation, analgesia would be provided. In the 35 responses where analgesia would be withheld, 21 (60%) believed pain was not severe enough, while 5 (14.3%) indicated it would obscure a surgical condition. CONCLUSIONS Pediatric emergency physicians self-reported rates of providing analgesia for acute abdominal pain scenarios were higher than previously reported, and appeared unrelated to request for surgical consultation. However, an unwillingness to provide opioid analgesia, belief that analgesia can obscure a surgical condition, and failure to take self-reported pain at face value remain, suggesting that the need exists for further knowledge translation efforts.
Assessments of Stress of Conscience, Perceptions of Conscience, Burnout, and Social Support Before and After Implementation of a Participatory Action-Research-Based Intervention

Interventions aiming to constructively address stress of conscience are rare. The aim of the study was to compare assessments of stress of conscience, perceptions of conscience, burnout, and social support among health care personnel (HCP) working in municipal residential care of older adults, before and after participation in a participatory action research (PAR) intervention aiming to learn to constructively deal with troubled conscience. Questionnaire data were collected at baseline and at follow-up (1-year interval; n = 29). Descriptive statistics and nonparametric statistical tests were used to make comparisons between baseline and follow-up. HCP gave significantly higher scores to the question, “Are your work achievements appreciated by your immediate superior? ” at follow-up compared with baseline. No significant differences in levels of stress of conscience and burnout at follow-up were found. The results suggested that a PAR intervention aiming to learn HCP to deal with their troubled conscience in difficult situations could be partially successful.
Methyl-CpG-binding Protein, MeCP2, Is a Target Molecule for Maintenance DNA Methyltransferase, Dnmt1*

During mammalian cell division, DNA methylation patterns are transferred accurately to the newly synthesized DNA strand. This depends on maintenance DNA methyltransferase activity. DNA methylation can affect chromatin organization and gene expression by recruitment of histone deacetylases (HDACs). Here we show that the methyl-CpG binding protein, MeCP2, interacts directly with the maintenance DNA methyltransferase, Dnmt1. The region of MeCP2 that interacts with Dnmt1 corresponds to the transcription repressor domain which can also recruit HDACs via a corepressor, mSin3A. Dnmt1 can form complexes with HDACs as well as MeCP2. Surprisingly, the MeCP2-Dnmt1 complex does not contain the histone deacetylase, HDAC1. Thus, Dnmt1 takes the place of the mSin3A-HDAC1 complex, indicating that the MeCP2-interacting Dnmt1 does not bind to HDAC1. Further, we demonstrate that MeCP2 can form a complex with hemimethylated as well as fully methylated DNA. Immunoprecipitated MeCP2 complexes show DNA methyltransferase activity to hemimethylated DNA. These results suggest that Dnmt1 associates with MeCP2 in order to perform maintenance methylation in vivo. We propose that genome-wide and/or -specific local DNA methylation may be maintained by the Dnmt1-MeCP2 complexes, bound to hemimethylated DNA. Dnmt1 may be recruited to targeted regions via multiple steps that may or may not involve histone deacetylases.
Frontal lobe damage produces episodic memory impairment

Abstract This article reports the outcome of a meta-analysis of the relation between the frontal lobes and memory as measured by tests of recognition, cued recall, and free recall. We reviewed experiments in which patients with documented, circumscribed frontal pathology were compared with normal control subjects on these three types of tests. Contrary to conventional wisdom, there is strong evidence that frontal damage disrupts performance on all three types of tests, with the greatest impairment in free recall, and the smallest in recognition. (JINS, 1995, 1, 525–536.)
Self-reported childhood trauma correlates with schizotypal measures in schizophrenia but not bipolar pedigrees

Background Strong evidence supports the association between childhood trauma and psychotic disorders. In two different high-risk populations, we looked for a correlation between the magnitude of schizotypal dimensions and the importance of self-reported childhood trauma. Method A sample of 138 unaffected first-degree relatives was recruited (67 relatives of schizophrenic probands and 71 relatives of bipolar probands). The relationship between schizotypal dimensions and childhood trauma scores was analyzed by partial correlations. Results A positive correlation was found between childhood trauma scores and total schizotypal scores in first-degree relatives of schizophrenic subjects but not in first-degree relatives of bipolar probands. This correlation was primarily due to a strong association with the positive dimension of schizotypy. Conclusions The significant correlation between childhood trauma and schizotypal dimensions in subjects at high genetic risk for schizophrenia suggests that susceptibility genes for schizophrenia may interact with childhood trauma to induce the emergence of schizotypal dimensions, mainly positive psychotic features.
Communication between the Perilymphatic Scalae and Spiral Ligament Visualized by in vivo MRI

We evaluated the transport of Gadolinium-diethylenetriaminepentaacetate-bismethylamide (Gd-DTPA-BMA) through the round window (RW) membrane into the perilymphatic space with 4.7-T MRI in an animal study and 1.5-T MRI in humans. After administration of Gd-DTPA-BMA onto the intact RW membrane of guinea pig, Gd-DTPA-BMA uptake was observed in the basal turn and part of the second turn within 40 min. The scala tympani, scala vestibuli, the fibrous part of the spiral ligament and semicircular canal all showed uptake of Gd-DTPA-BMA. All turns of the cochlea were filled with Gd within 10 min in the perforated RW membrane administration group and within 30 min in the intravenous administration group. In patients who accepted middle ear injection of Gd-DTPA-BMA, uptake was observed within 2 h in the basal turn and semicircular canal. After 12 h the apex did still not show any uptake. Gd-DTPA-BMA is transported from the RW to the semicircular canal, the scala tympani and scala vestibuli without passing the helicotrema.
Intrinsic group behaviour: Dependence of pedestrian dyad dynamics on principal social and personal features

Being determined by human social behaviour, pedestrian group dynamics may depend on “intrinsic properties” such as the purpose of the pedestrians, their personal relation, gender, age, and body size. In this work we investigate the dynamical properties of pedestrian dyads (distance, spatial formation and velocity) by analysing a large data set of automatically tracked pedestrian trajectories in an unconstrained “ecological” setting (a shopping mall), whose apparent physical and social group properties have been analysed by three different human coders. We observed that females walk slower and closer than males, that workers walk faster, at a larger distance and more abreast than leisure oriented people, and that inter-group relation has a strong effect on group structure, with couples walking very close and abreast, colleagues walking at a larger distance, and friends walking more abreast than family members. Pedestrian height (obtained automatically through our tracking system) influences velocity and abreast distance, both growing functions of the average group height. Results regarding pedestrian age show that elderly people walk slowly, while active age adults walk at the maximum velocity. Groups with children have a strong tendency to walk in a non-abreast formation, with a large distance (despite a low abreast distance). A cross-analysis of the interplay between these intrinsic features, taking in account also the effect of an “extrinsic property” such as crowd density, confirms these major results but reveals also a richer structure. An interesting and unexpected result, for example, is that the velocity of groups with children increases with density, at least in the low-medium density range found under normal conditions in shopping malls. Children also appear to behave differently according to the gender of the parent.
N-MYC and C-MYC Oncogenes Amplification in Medulloblastomas. Evidence of Particularly Aggressive Behavior of a Tumor with C-MYC Amplification

N-myc and c-myc amplification was investigated in 27 medulloblastomas. DNA was extracted from 19 formalin fixed and paraffin embedded tumors and from fresh frozen tumor tissue in 8 other cases. The results showed no evidence of amplification of N-myc oncogene and only 1 case had a 27 fold amplification of c-myc. Cytogenetically, this neoplasm presented numerous double minute chromosomes (DMs). Moreover, it had an unusual rapidly aggressive course with massive cerebrospinal fluid dissemination unresponsive to intrathecal chemotherapy. Our results indicate a low incidence of N-myc and c-myc gene amplification in medulloblastomas, suggesting that the oncogenic mechanism in these neoplasms is not closely related to DNA gene amplification. C-myc amplification, although not frequently observed, may however provide a growth advantage for medulloblastoma cells in vivo, favoring their rapid dissemination. Medulloblastomas with c-myc activation may represent a subgroup of tumors with a more aggressive behavior.
Transient Strain Measurements of a Suspended Cable Under Impact Loadings Using Fiber Bragg Grating Sensors

The theoretical and experimental studies of fiber Bragg grating (FBG) sensors is investigated. In the theoretical studies, the coupled-mode theory with transfer matrix method is used to simulate the dynamic responses of the FBG sensors subjected to a sinusoidal strain wave. The numerical results indicate that the increase of frequency and amplitude of strain wave result in signal distortion, hence the signal distortion limit is established to analyze the FBG dynamic sensing range. In the experimental studies, the FBG sensors as well as the strain gage are used to measure simultaneously the transient responses of dynamic strain for a suspended cable under impact loadings. The frequency spectra of the measuring results for transient responses of dynamic strain are analyzed and the natural frequencies of the cable are determined. The natural frequencies obtained from experimental measurements have excellent agreement for different sensors and different impact positions. In addition, the experimental results also have good correspondence with the theoretical analysis and the finite-element method (FEM). According to the available experimental results, it is proved that the FBG sensor has excellent ability of transient strain measurement for structures with curved surface and large curvature and has better performance than the traditional strain gage.
Impact of the biased nucleotide composition of viral RNA genomes on RNA structure and codon usage.

We are interested in the influence of nucleotide composition on the fundamental characteristics of the virus RNA genome. Most RNA viruses have genomes with a distinct nucleotide composition, e.g. ranging from minimally 12.9 % to maximally 40.3 % (C- and U-count, respectively, in coronavirus HKU). We present a global analysis of diverse virus types, including plus-strand, minus-strand and double-strand RNA viruses, for the impact of this nucleotide preference on the predicted structure of the RNA genome that is packaged in virion particles and on the codon usage in the viral open reading frames. Several virus-specific features will be described, but also some general conclusions were drawn. Without exception, the virus-specific nucleotide bias was enriched in the unpaired, single-stranded regions of the RNA genome, thus creating an even more striking virus-specific signature. We present a simple mechanism that is based on elementary aspects of RNA structure folding to explain this general trend. In general, the nucleotide bias was the major determinant of the virus-specific codon usages, thus limiting a role for codon selection and translational control. We will discuss molecular and evolutionary scenarios that may be responsible for the diverse nucleotide biases of RNA viruses.
Validation of the Parkinson Fatigue Scale in Chinese Parkinson's disease patients

Fatigue is a common nonmotor symptom in Parkinson's disease (PD); however, the Parkinson's disease fatigue scale (PFS), which is designed to measure fatigue in PD, has not been validated in China. The aim of this study was to determine the validity and reliability of the Chinese version of the PFS in PD patients.
Venous Leg Ulcer Care: How Evidence–Based Is Nursing Practice?

Objectives The objectives of this study were to (1) determine how congruent community-provided leg ulcer care was with best practice for venous leg ulcers and (2) identify organizational and clinical factors associated with the provision of best practice for venous leg ulcers. Design The practice variation study group was an audit of nursing agency client records to determine the provision of care. Setting and subjects The study population was a home care cohort of persons with venous leg ulcers (n = 66) who received care from one Ontario home care nursing agency between March 1999 and November 1999. Instrument The audit tool was developed with a checklist reflecting the common recommendations from 3 international practice guidelines, as well as organizational and clinical factors that may influence or reflect best practice. Results Half of client records (35/66) included an identified etiology of the leg ulcer. An Ankle Brachial Pressure Index score was documented prior to the initiation of compression on fewer than half of the records (21/44). Regular ulcer measurement was done for 11% of the clients (7/64). Two thirds of the clients (44/66) were treated with compression. More than 60% of the clients (40/66) had been seen by either a dermatologist or a vascular surgeon. Topical antibiotics were prescribed for two thirds of clients (44/64). Fifteen percent of clients (10/66) were assessed for pain, and 17% (11/66) received some form of pain management. Documentation of client education specific to the leg ulcer was present on 3% of records (2/66). The mean number of different nurses providing leg ulcer care to each client was 19. A registered practical nurse was the classification of nurse assigned to 43.8% (29/66) of the clients. Conclusion Several gaps were identified in the care provided. A standardized approach to care is needed that includes a comprehensive leg ulcer assessment to determine the ulcer etiology, determination of an Ankle Brachial Pressure Index score to screen for the presence of arterial disease, and compression for all clients who meet the criteria for venous disease. A reorganization of services is required, which includes an increased role for community nurses in leg ulcer assessment and management. Organizational and clinical factors influencing the delivery of best practice need to be identified and addressed.
Performance Determinants of Kenya Certificate of Secondary Education (KCSE) in Mathematics of Secondary Schools in Nyamaiya Division, Kenya

The study found the performance determinants of students’ performance in mathematics Kenya certificate of secondary education (KCSE) in Nyamaiya division of Kenya. The study employed descriptive survey design of the ex-post facto type with a total student population of 151 and 12 teachers. Four validated research instrument developed for the study were Mathematics Achievement Test (MAT) (r = 0.67), Students Questionnaire (SQ) (r = 0.75), Teachers Questionnaire (TQ) (r = 0.60 and Head teachers Questionnaire (HQ) (r = 0.70). Three research questions were answered. The data was analyzed using multiple regression analysis. There was a positive correlation among the six independent variables and the dependent measure – mathematics performance(R= 0.238; F(6,151)=1.53843; p<0.05). The six variables accounted for 45.6% of the total variance in the independent measure (R2 = 0.564). Teachers’ experience (B=0.972, t=2.080; p<0.05), teachers’ qualification (B=0.182, t=2.390; p<0.05), teachers/students’ attitude (B=0.215, t= 2.821; p<0.05) and school category (B=0.064, t=0.352; p<0.05) could be used to predict students’ academic performance in mathematics. It is therefore recommended that adequate attention should paid to these variables that can predict students’ performance by the government and other stakeholders of education in Kenya.