Miracle-dz/UniFAR-FTUs huggingface dataset:
Dynamics of Type I and Type II Interferon Signature Determines Responsiveness to Anti-TNF Therapy in Rheumatoid Arthritis

The factors influencing long-term responses to a tumor necrosis factor inhibitor (TNFi) in rheumatoid arthritis (RA) patients currently remain unknown. Therefore, we herein conducted a multi-omics analysis of TNFi responses in a Japanese RA cohort. Blood samples were collected from 27 biological disease-modifying antirheumatic drug (DMARD)-naive RA patients at the initiation of and after three months of treatment with TNFi. Treatment responses were evaluated at one year. Differences in gene expression levels in peripheral blood mononuclear cells (PBMCs), plasma protein levels, drug concentrations, and the presence/absence of anti-drug antibodies were investigated, and a cell phenotypic analysis of PBMCs was performed using flow cytometry. After one year of treatment, thirteen patients achieved clinical remission (responders), while the others did not or switched to other biologics (non-responders). Differentially expressed genes related to treatment responses were enriched for the interferon (IFN) pathway. The expression of type I IFN signaling-related genes was higher in non-responders than in responders before and after treatment (P = 0.03, 0.005, respectively). The expression of type II IFN signaling-related genes did not significantly differ before treatment; however, it increased in non-responders and decreased in responders, with a significant difference being observed after three months of treatment (P = 1.2×10-3). The total number of lymphocytes and C-X-C Motif Chemokine Ligand 10 (CXCL10) protein levels were associated with the type I IFN signature (P = 6.7×10-7, 6.4×10-3, respectively). Hepatocyte growth factor (HGF) protein levels before treatment predicted fold increases in type II IFN (P = 0.03). These IFN signature-related indices (the number of lymphocytes, CXCL10, and HGF) significantly differed between responders and non-responders (P = 0.01, 0.01, and 0.04, respectively). A single-cell analysis revealed that the type I IFN signature was more highly enriched in monocytes than in other cell types. A deconvolution analysis of bulk-RNA sequence data identified CD4+ and CD8+ T cells as the main sources of the type II IFN signature in non-responders. Collectively, the present results demonstrated that the dynamics of the type I and II IFN pathways affected long-term responses to TNFi, providing information on its biological background and potential for clinical applications.
The relation between mirror movements and non‐use of the affected hand in children with unilateral cerebral palsy

In children with unilateral cerebral palsy (CP), it is widely believed that mirror movements contribute to non‐use of the affected hand despite preserved capacity, a phenomenon referred to as developmental disregard. We aimed to test whether mirror movements are related to developmental disregard, and to clarify the relation between mirror movements and bimanual function.
Are hsps suitable for indicating stressed states in fish?

SUMMARY In response to most stressors, fish will elicit a generalized physiological stress response, which involves the activation of the hypothalamic-pituitary-interrenal axis (HPI). As in other vertebrates, this generalized stress response comprises physiological responses that are common to a wide range of environmental, physical and biological stressors. Recently, several families of heat shock proteins (hsps) have been proposed as indicators of a generalized stress response at the cellular level. Recent findings that hsp levels, in various fish tissues, respond to a wide range of stressors have supported the use of these proteins as indicators of stressed states in fish. However, the cellular stress response can vary, for example, according to tissue, hsp family and type of stressor. This brief overview of these responses in fish asks the question of whether changes in levels and families of hsps can be used as a suitable indicator of stressed states in fish. By casting this question in the context of the well-established generalized physiological stress response in fish, we argue that the use of hsps as indicators of stressed states in fish in general is premature.
Issues for the Assessment of Visuospatial Skills in Older Adults Using Virtual Environment Technology

Virtual Environment (VE) technology offers clinical assessment and rehabilitation options that are currently not available using traditional neuropsychological methods. Advancements in this type of immersive information technology could produce tools that enhance the scientific study of human cognitive/functional processes and improve our capacity to more accurately assess and treat impairments found in persons with central nervous system (CNS) dysfunction. Through the creation of dynamic three-dimensional (3D) stimulus environments, in which all behavioral responding can be recorded, VE technology offers the possibility to more sensitively address a range of age-related CNS disorders including Alzheimer's Disease, Vascular Dementia, Parkinson's Disease, and stroke. Advances in this area could impact quality of life issues for an increasingly aging world population. The VE Laboratory at the University of Southern California has developed a suite of ImmersaDesk-format, 3D projection-based VEs. These scenar.
Perceived Risk of Bovine Spongiform Encephalopathy and Dietary Behavior

The German BSE crisis in early 2001 can be considered as a natural experiment with strong behavioral consequences. The present study investigated psychological and other factors associated with reduced meat consumption compared to the first months of the previous year. As expected, all types of meat, with the exception of poultry and game, were eaten less often. The effect was strongest in beef, where almost half of the sample reported reduced meat consumption. As predicted by the health belief model, perceived threat was associated with subjective vulnerability. It was not, however, strongly associated with perceived seriousness of BSE, probably due to the ubiquitous public discussion of the topic. Reduced beef consumption has three to four times more frequent in the event of subjective threat.
Laryngeal nerve paralysis and benign thyroid disease.

PREOPERATIVE paralysis of a recurrent laryngeal nerve is far more commonly associated with malignant than benign disease of the thyroid gland. Ceroni et al,1in a series of 100 cases, showed that 24% of recurrent laryngeal nerve paralyses were associated with benign conditions. Cunning,2in a much larger series, showed the incidence to be only 2.3%. The present article records an additional eight cases occurring in a series of 1,200 consecutive patients with thyroid disease undergoing thyroidectomy. Materials and Methods A series of 1,200 consecutive patients admitted for thyroidectomy were examined routinely preoperatively for evidence of laryngeal nerve paralyses. This was a highly select group, clinical examination excluding all but those with thyroid disease. Vocal cord paralysis was used to determine recurrent laryngeal nerve paralysis, both preoperatively and postoperatively. The vocal cords were examined within seven days postoperatively to determine the result of surgical removal of the thyroid
Gender differences in energy expended during activities and in daily energy expenditure of elderly people.

Gender effects on energy expended during light seated activities, walking, cycling, and sleep and their consequences on daily energy expenditure (EE) were examined in 11 men and 15 women aged 66.4 +/- 7.1 yr. Two open-circuit whole body calorimeters were used for EE measurements, except for cycling, during which EE was measured separately with the use of a face mask. Lean body mass (determined using H218O dilution method), fat mass, usual physical activity level, and activity intensity (e.g., walking speed and cycling power output) were taken as covariates in the analysis of EE variations before studying gender effects. Sleeping metabolic rate (SMR) and daily EE, adjusted for differences in all covariates, were 11.2 (P = 0.005) and 8.7% (P = 0.071) lower in women than in men, respectively. No gender-related differences were found in the various physical activity EEs above SMR (e.g., gross EE-SMR) [light seated activities (P = 0.790), walking (P = 0.263), and cycling (P = 0.287)] and daily physical activity EE above SMR (P = 0.587) after adjustment for differences in all covariates. Therefore, the lower adjusted daily EE of women could be related to their lower SMR, the most reliable criterion of whole body metabolic rate.
Pharmacological Characterization of N-tert-Butyl-N′-[2-(4′-methylphenylamino)-5-nitrobenzenesulfonyl]urea (BM-573), a Novel Thromboxane A2 Receptor Antagonist and Thromboxane Synthase Inhibitor in a Rat Model of Arterial Thrombosis and Its Effects on Bleeding Time

The present study was undertaken to characterize the antiplatelet and antithrombotic effects of BM-573 [N-tert-butyl-N′-[2-(4′-methylphenylamino)-5-nitrobenzenesulfonyl]urea], an original combined thromboxane receptor antagonist and thromboxane synthase inhibitor in rats, and to determine its effects on mice bleeding time. Intraperitoneal injection of a single dose of 5 mg/kg BM-573 to rats inhibited U-46619 (9,11-dideoxy-9,11-methanoepoxy-prostaglandin F2)-induced washed platelet aggregation 30 min and 1, 2, and 4 h after drug administration with a maximum antiplatelet effect observed after 1 and 2 h. In a rat model of thrombosis induced by ferric chloride application on the abdominal aorta, BM-573 significantly reduced the thrombus weight by 92.53, 80.20, 64.75, and 18.21% at doses of 5, 2, 0.5, and 0.2 mg/kg, respectively. Time to occlusion of abdominal aorta in the BM-573-treated group (41.50 ± 5.21 min) was significantly prolonged compared with the vehicle-treated rats (16.16 ± 0.79 min). Like furegrelate, seratrodast, and acetylsalicylic acid, BM-573 did not affect the tail bleeding time induced by tail transection in mice compared with vehicle-treated mice. Moreover, BM-573, a close derivative of the loop diuretic torasemide, failed to induce a significant increase in diuresis in rat and did not produce a decrease in blood glucose concentration as observed with the sulfonylurea glibenclamide. In conclusion, we have demonstrated that the nitrobenzenic sulfonylurea BM-573, an original combined thromboxane receptor antagonist and thromboxane synthase inhibitor, is a potent antithrombotic agent that does not affect bleeding time. Moreover, BM-573 lost the diuretic property of torasemide and has no impact on glycemia.
Haploid Helps Phaeocystis Globosa Distribute to Deeper Dim Water, as Evidenced by Growth and Photosynthetic Physiology

Phaeocystis globosa has a haplo-diplontic alternative life cycle and is an important causative species of harmful algal blooms. Diploid solitary cells of Phaeocystis can form colonies and bloom in the surface water. However, haploid cells are abundant in deep water rather than surface water. We hypothesize that the haploid cells of Phaeocystis globosa could better adapt to deep dim water than its diploid cells. Haploid and diploid solitary cells of P. globosa were cultured with eutrophic medium (f/2) under moderately low (15 µmol photons m-2 s-1), extremely low (5 µmol photons m-2 s-1) and normal (60 µmol photons m-2 s-1) irradiance conditions. The results showed that irradiances used in this study did not induce reactive oxygen species (ROS) damage in either haploid or diploid cells. Both haploid and diploid solitary cells grew faster at higher irradiance during the initial exponential growth phase. However, the haploid abundances under moderately and extremely low irradiances were higher than that under normal irradiance after the exponential growth phase, but diploid cells formed more colonies at higher irradiances. An increase in the photosynthetic pigments (PSC) ratio combined with a reduction in photoprotective pigments (PPC) ratio were found in both ploidies with decreasing irradiance, but the ratios of PSC and PPC and xanthophyll cycle pigments were significantly higher in haploid cells than in diploid cells. For haploids, the highest potential photochemistry efficiency of photosystems П was found under extremely low irradiance, but for diploids, it was observed under moderately low irradiance. The results suggest that both haploid and diploid solitary cells of P. globosa in eutrophic water can survive under low-light conditions, but haploid cells have an advantage in extremely low irradiance.
Emotion Dysregulation as a Core Feature of Borderline Personality Disorder: Comparison of the Discriminatory Ability of Two Self-Rating Measures

Background/Aims: There is growing evidence that emotion dysregulation (ED) is a core feature of borderline personality disorder (BPD). The present study examines whether a self-rating measure, the ED Scale, lets us distinguish between individuals with BPD and those diagnosed with other mental disorders in a way similar to that of a borderline-related screening measure, the German version of the McLean Screening Instrument for Borderline Personality Disorders (MSI-BPD). Method: Based on the signal detection theory, receiver operating characteristics as well as reliability and validity indicators are determined in a heterogeneous outpatient sample (n = 168). Results: The values of internal consistency and the validity indicators turned out to be in the expected range. The area under the curve (AUC) for the ED Scale was 0.86, and therefore emerged on a par with the AUC = 0.90 of the MSI-BPD. As required, analyses for both measures revealed equal and high values for sensitivity, as well as corresponding low negative predictive values. There was, however, a lower degree of specificity on the ED Scale as compared to the MSI-BPD. Conclusion: The results support the assumption that ED is a core feature of BPD, but should also be taken into account in the assessment and treatment of other mental disorders.
Generation of a mouse tumor necrosis factor mutant with antiperitonitis and desensitization activities comparable to those of the wild type but with reduced systemic toxicity

In this study, we investigated whether the recently identified lectin-like domain of tumor necrosis factor (TNF) is implicated in its biological activities on mammalian cells. To this end, a mouse TNF (mTNF) triple mutant, T104A-E106A-E109A mTNF (referred to hereafter as triple mTNF), lacking the lectin-like affinity of mTNF for specific oligosaccharides, was compared with the wild-type molecule for various TNF effects in vitro and in vivo. The triple mTNF displayed a 50-fold-reduced TNF receptor 2 (TNFR2)-mediated bioactivity but only a 5-fold-reduced TNFR1-mediated bioactivity in vitro. The specific activity of the triple mutant on L929 fibrosarcoma cells was slightly reduced compared with that of the wild type. We subsequently assessed the systemic toxicity of triple versus wild-type mTNF, since TNFR2 is partially implicated in this activity. The triple mTNF had a significantly reduced toxicity compared with that of wild-type mTNF in vivo. Moreover, we compared the effects of the triple and the wild-type mTNFs in TNFR1-mediated phenomena, such as (i) induction of tolerance towards a lethal mTNF dose and (ii) protective activity in cecal ligation and puncture-induced septic peritonitis. No significant differences between the mutant and wild-type forms were observed. In conclusion, these results indicate that triple mTNF, lacking TNF's lectin-like binding capacity, has reduced systemic toxicity but retains the tolerance-inducing and peritonitis-protective activities of wild-type mTNF.
AKINEMATIC COMPARISON OF DEEP WATER RUNNING AND OVERGROUND RUNNING IN ENDURANCE RUNNERS

Deep water running (DWR) is commonly used as a rehabilitative tool or as a running specific cross-training modality. However, because little is known about the biomechanical specificity of this training, the aim of this study was to compare the leg kinematics of DWR vs. overground running (OGR). Five endurance runners' leg actions in the sagittal plane were filmed in 2 dimensions in DWR and OGR at slow (72 cycles·min-1) and fast (92 cycles·min-1) frequencies to measure hip and knee angles. Hip-knee angle-angle diagrams were quantified using cross-correlations (r). Leg motion was different between DWR and OGR both kinematically (e.g., hip maximum flexion angle, slow frequency: DWR = 92 ± 20° OGR = 49 ± 10° p < 0.05) and in coordination (e.g., slow frequency: DWR, r = −0.94, lag = −1%; OGR, r = 0.87, lag = 22%). The time lag indicates that the hip and knee flex and extend together in DWR, whereas the hip moves before the knee during OGR. Stride frequency had an effect on OGR but not on DWR. The apparent differences between DWR and OGR are likely to affect muscle recruitment patterns and this could be problematic for athletes with hip and knee injuries. Because the negative effects of DWR as a rehabilitative tool are not known, gradual familiarization to DWR prior to a prescribed DWR rehabilitation or intense fitness maintenance program is recommended to offset any adverse affects.
Smoking Cessation Treatment Practices: Recommendations for Improved Adoption on Cardiology Wards

Background and Objectives:Smoking cessation treatment practices described by the 5 A’s (ask, advise, assess, assist, arrange) are not well applied at cardiology wards because of various reasons, such as a lack of time and appropriate skills of the nursing staff. Therefore, a simplified guideline proposing an ask-advise-refer (AAR) strategy was introduced in Dutch cardiac wards. This study aimed to identify factors that determine the intentions of cardiac ward heads in adopting the simplified AAR guideline, as ward heads are key decision makers in the adoption of new guidelines. Ward heads’ perceptions of current smoking cessation practices at the cardiac ward were also investigated. Methods:A cross-sectional survey with written questionnaires was conducted among heads of cardiology wards throughout the Netherlands, of whom 117 (64%) responded. Results:According to the heads of cardiac wards, smoking cessation practices by cardiologists and nurses were mostly limited to brief practices that are easy to conduct. Only a minority offered intensive counseling or arranged follow-up contact. Heads with strong intentions of adopting the AAR guideline differed significantly on motivational and organizational attributes and perceived more smoking cessation assistance by other health professionals than did heads with weak intentions of adopting. Positive attitudes, social support toward adoption, and perception of much assistance at the ward were significantly associated with increased intentions to adopt the AAR guideline. Conclusions:Brief smoking cessation practices are adequately performed at cardiac wards, but the most effective practices, offering assistance and arranging for follow-up, are less than optimal. The AAR guideline offers a more feasible approach for busy cardiology wards. To ensure successful adoption of this guideline, the heads of cardiac wards should be convinced of its advantages and be encouraged by a supportive work environment. Policies may also facilitate the adoption of the AAR guideline.
Sectoral Analysis of Impact of Foreign Aid in Nigeria : A Dynamic Specification

1.0 Introduction Foreign aid represents an important source of finance in most countries in Sub-Sahara Africa (SSA), including Nigeria, where it can supplement low savings, narrow export earning s and thin tax bases. In fact, foreign aid is considered to be a major supplement to government expenditure in Nigeria. Foreign aid stimulates economic growth by supplementing domestic sources of finance such as savings, thus increasing the amount of investment and capital stock in the country. Aid also increases; investment in physical and human capital, capacity to import capital goods or technology and it is also associated with technology transfer that increases productivity of capital and promotes endogenous technical change (Njeru, 2003). All these are influenced by external, climatic, political and institutional conditions. Foreign aid can have positive effect on economic growth, through public expenditure if properly channeled to the productive sectors of the economy (Odusanya et al, 2011). Consequently, donor countries have begun to mobilize additional resources for the needs of developing countries. Several donors have pledged to reach the United Nation's target level (0.7 percent of donor's gross national income) for Official Development Assistance (ODA) over the next decade and which they have begun to significantly increase. In fact, as at 2009, countries such as Sweden (1.12 % of GNI), Norway (1.06% of GNI), Luxembourg (1.04% of GNI), Denmark (0.88% of GNI) and Netherlands (0.82% of GNI) have exceeded 0.7 percent of donor's gross national income pledge for ODA as indicated in Figure 1.
Survey for Encephalitozoon cuniculi in Arctic Foxes (Alopex lagopus) in Greenland

Wild arctic foxes (Alopex lagopus) from Greenland were tested for antibodies to Encephalitozoon cuniculi with an enzyme-linked immunosorbent assay and a carbon immunoassay. Of 230 tested foxes none was seropositive. This finding contrasts with observations from other arctic areas and absence of rodents in the diet of these arctic foxes is the most likely explanation for absence of E. cuniculi.
Coronary Restenosis After Sirolimus‐Eluting Stent Implantation: Morphological Description and Mechanistic Analysis From a Consecutive Series of Cases

Background We describe the clinical and morphological patterns of restenosis after sirolimus‐eluting stent (SES) implantation. Methods and Results From 121 patients with coronary angiography obtained >30 days after SES implantation, restenosis (diameter stenosis >50%) was identified in 19 patients and 20 lesions (located at the proximal 5‐mm segment in 30% or within the stent in 70%). Residual dissection after the procedure or balloon trauma outside the stent was identified in 83% of the proximal edge lesions. Lesions within the stent were focal, and stent discontinuity was identified in some lesions evaluated by intravascular ultrasound. Conclusions Sirolimus‐eluting stent edge restenosis is frequently associated with local trauma outside the stent. In‐stent restenosis occurs as a localized lesion, commonly associated with a discontinuity in stent coverage. Local conditions instead of intrinsic drug‐resistance to sirolimus are likely to play a major role in post‐SES restenosis. (Circulation. 2003; 108:257‐260.)
The Role of Parenting in Drug Use Among Black, Latino and White Adolescents

Abstract This study investigates the role of parenting in adolescent drug use for black, white and Latino adolescents. Parenting has been consistently identified as a crucial factor in drug use by adolescents. This study uses data from the National Longitudinal Study of Adolescent Health. Results show that parenting has a significant effect on drug use for these adolescents. The relationship between parenting and drug use is more strongly negative for the Latino adolescents, than for black and white adolescents. This indicates that greater parental warmth and family acceptance exert a stronger impact in reducing drug use for Latino adolescents than is the case for the black and white adolescents.