Miracle-dz/UniFAR-FTUs huggingface dataset:
Subintimal Angioplasty of Isolated Infragenicular Vessels in Lower Limb Ischemia: Long-term Results

Purpose: To assess the outcome of subintimal angioplasty in treating isolated infragenicular arterial disease in patients with severe lower limb ischemia. Methods: A retrospective study reviewed 67 consecutive patients (39 men; mean age 76 years, range 41–96) who underwent infragenicular subintimal angioplasty between March 1997 and May 2000 for ischemia in 70 limbs. The median length of occlusion was 6 cm (range 1–10) in the below-knee popliteal arteries, 4 cm (range 1–4) in the tibioperoneal trunk, 21 cm(range 1–35) in the anterior tibial artery, 10 (1–30) in the posterior tibial artery, and 5 (range 1–20) in the peroneal artery. Results: The technical and clinical success rates were 86% and 80%, respectively. In the 10 (14%) patients with a technical failure, 3 underwent successful bypass, 4 had an amputation, 1 had a lumbar sympathectomy, and 2 were treated conservatively. Of the 4 (6%) limbs that did not achieve clinical success, 2 patients required femorodistal bypass and their ulcers improved; in the other 2, ulcerations did not heal completely. The cumulative limb salvage rate and freedom from critical limb ischemia (CLI) quantified by Kaplan-Meier life-table analysis were 94% and 84% at 36 months. Mortality rates were 19% at 1 year, 43% at 2 years, and 51% at 3 years. In a subgroup analysis, the rate of CLI was significantly lower in nondiabetics (4%) and than in diabetics (24%, p=0.02), but neither survival nor amputation rates were significantly different. Conclusions: Subintimal angioplasty is a safe and effective procedure for treating isolated crural vessels in patients with severe lower limb ischemia.
AlGaN/GaN HEMTs With Low Leakage Current and High On/Off Current Ratio

In this letter, we propose using an oxide-filled isolation structure followed by N<sub>2</sub>/H<sub>2</sub> postgate annealing to reduce the leakage current in AlGaN/GaN HEMTs. An off-state drain leakage current that is smaller than 10<sup>-9</sup> A/mm (minimum 5.1 × 10<sup>-10</sup> A/mm) can be achieved, and a gate leakage current in the range of 7.8 ×10<sup>-10</sup> to 9.2 × 10<sup>-11</sup>A/mm (<i>V</i> <sub>GS</sub> from -10 to 0 V and <i>V</i> <sub>DS</sub> = 10 V) is obtained. The substantially reduced leakage current results in an excellent on/off current ratio that is up to 1.5 × 10<sup>8</sup>. An improved flicker noise characteristic is also observed in the oxide-filled devices compared with that in the traditional mesa-isolated GaN HEMTs.
A health education program for elderly persons with visual impairments and perceived security in the performance of daily occupations: a randomized study.

OBJECTIVE The purpose of this randomized, longitudinal study was to investigate the impact of a health education program on perceived security in the performance of daily occupations 4 months after the intervention period. METHOD Two groups of persons with age-related macular degeneration were compared: Those who had followed a newly developed health education program that was based on occupation and those who took part in a standard individual intervention program. RESULTS Significant differences in the level of perceived security between the groups were found for 13 of 28 occupations. Participants in the health education group maintained or improved their level of perceived security in 22 daily occupations, whereas those in the individual intervention group declined to a lower level in 17 daily occupations. CONCLUSION This study provides support for the effectiveness of the health education program to enhance security and hinder a progressive decline in perceived security in daily occupations.
Investor attention and Portuguese stock market volatility: We’ll google it for you!

The aim of this work is to analyze the influence of investor attention on the Portuguese stock market activity and volatility. As a proxy of investor attention, we use investors’ online search behavior, both at the individual stock and the overall market level, provided by Google Trends. The econometric analysis is performed both for each stock and for the index portfolio. The model include both market states and the crisis effects. As introduced by previous studies, Google search volume revealed to be a reliable proxy of investor attention and to be a significant determinant of the contemporaneous stock market historical volatility. The results are robust even after controlling for variations in market returns and market volume. Moreover, the model estimates revealed that the impact of investor attention seems to be more sensitive to the high-return market state and becomes stronger during periods of crisis.
EU quality labels in the Italian olive oil market: How much overlap is there between geographical indication and organic production?

ABSTRACT In the early 1990s, the European Union established two main quality schemes: geographical indications (GIs) and organic production (OP). Despite the abundant literature on the EU quality schemes applied to many food categories, including extra virgin olive oil, in most studies, GIs and OP are analysed separately, under the assumption that they are independent. This study aims to prove that synergies exist between GIs and OP labels. We analysed EU labelling on GIs and organic attributes simultaneously using bivariate probit models, and also assessed the level of independence from each other. A survey was administered to Italian consumers to elicit their purchasing behaviour of olive oil. The results found a correlation between the two certifications, highlighting the promising use of both certifications for olive oil products.
Patterns of major histocompatibility complex class II expression by T cell subsets in different immunological compartments. 2. Altered expression and cell function following activation in vivo

This study characterizes antigen‐induced phenotypic and functional aspects of major histocompatibility complex (MHC) class II expression on recirculating T cells in efferent lymph. In vivo secondary, but not primary challenge is associated with both kinetic and phenotypic alterations in class II expression by T cells. All three major T cell subsets, CD4+, CD8+ and T19+ (γδ T cell receptor), show an approximate four fold increase in the level of MHC class II expression during secondary responses. No changes in B cell expression of class II were seen. Resting efferent lymph T cells are predominantly either class II− or DR+DQ− but this changes to DR+DQ+ after antigenic challenge.
Coexistence of malignancies with bullous pemphigoid.

To the Editor. — The relationship of bullous pemphigoid to malignancy is still a controversial problem in spite of multiple reported cases. Some authors regard the association as a real one, 1,2 and others regard it as merely a fortuitous coexistence, 3,5 while still others point to a significantly higher incidence of malignancies in cases of pemphigoid in which the patients have low titers or no detectable serum antibody to the basement membrane zone. 6 Therefore, we have made an analysis of cases of bullous pemphigoid seen in our department during the period of 1968 to 1977. Malignant tumors were found in 12 of 110 (11%) cases of bullous pemphigoid, with six in 54 women and six in 56 men. These tumors included four breast cancers, two cancers of the prostate, two lymphoreticular malignancies, and one malignant tumor of each of the following tissues: lung, thyroid, larynx, and skin. In addition
Impact of Hydrocortisone Hemisuccinate Use on Outcome of Severe Scorpion-Envenomed Adult Patients

The aim of this study is to analyze if the infusion of hydrocortisone hemisuccinate improve outcome in severe scorpion-envenomated adult patients admitted to intensive care unit (ICU). Pairwise retrospective case–control study with 1:1 matching was designed. Patients were defined as cases when they received hydrocortisone hemisuccinate (as alone steroids) during hospitalization and as controls when they did not received any steroids. Patients were matched according to age, severity factors at admission represented by the presence of pulmonary edema and grades of severity of scorpion envenomation, and scorpion antivenom administration. Eighty-four patients were included as follows: 42 patients in the cases group and 42 patients in the control group. The mean age (±SD) was 40 ± 21 years, ranging from 16 to 90 years. Moreover, 67 (80%) patients have a systemic inflammatory response syndrome on ICU admission. The comparison between cases group and control group showed that age is not significantly different. There were the same proportions of patients with pulmonary edema in 2 groups. Moreover, 23 (54%) patients in case group and 23 (54%) in the control group received scorpion antivenom (P > 0.05). The mean temperature on admission was also not significantly different. The presence of systemic inflammatory response syndrome was again not significantly different between 2 groups. The comparison of outcome of the 2 groups showed that the use of mechanical ventilation and its duration, the ICU stay length, and ICU mortality was not significantly different between the 2 groups. Although our study has some limitations, it confirms that the use of hydrocortisone hemisuccinate in severe scorpion-envenomed patients did not improve their outcome.
Increased leisure-time physical activity associated with lower onset of diabetes in 44 828 adults with impaired fasting glucose: a population-based prospective cohort study

Aims To evaluate the effects of habitual leisure-time physical activity (LTPA) on incident type 2 diabetes in a prospective cohort of Chinese adults with impaired fasting glucose (IFG). Methods 44 828 Chinese adults aged 20–80 years with newly detected IFG but free from cardiovascular and cerebrovascular disease were recruited and followed up from 1996 to 2014. Incident type 2 diabetes was identified by fasting plasma glucose ≥7 mmol/L. The participants were classified into four categories based on their self-reported weekly LTPA: inactive, low, moderate, or high. Hazard ratios (HRs) and population attributable fractions (PAFs) were estimated with adjustment for established diabetic risk factor. Results After 214 148 person-years of follow-up, we observed an inverse dose–response relationship between LTPA and diabetes risk. Compared with inactive participants, diabetes risk in individuals reporting low, moderate and high volume LTPA were reduced by 12% (HR 0.88, 95% CI 0.80 to 0.99; P=0.015), 20% (HR 0.80, 95% CI 0.71 to 0.90; P<0.001), and 25% (HR 0.75, 95% CI 0.67 to 0.83; P<0.001), respectively. At least 19.2% (PAF 19.2%, 95% CI 5.9% to 30.6%) of incident diabetes cases could be avoided if the inactive participants had engaged in WHO recommendation levels of LTPA. This would correspond to a potential reduction of at least 7 million diabetic patients in the Greater China area. Conclusions Our results show higher levels of LTPA are associated with a lower risk of diabetes in IFG subjects. These data emphasise the urgent need for promoting physical activity as a preventive strategy against diabetes to offset the impact of population ageing and the growing obesity epidemic.
Managing risk with socially responsible actions in firms involved in controversial activities and earnings management

ABSTRACT This study examines the impact of earnings quality on the association between corporate social responsibility and firm’s risk in firms involved in controversial activities. Based on a US sample over the 2004–2008 period, we find that involvement in controversial issues increases risk of firms despite their engagement in social responsibility activities. Additionally, we find that firms involved in controversial activities that manage their earnings upward, increase levels of risk, no matter if they engage in social responsible actions or not.
Autogenous Augmentation Mammaplasty with Microsurgical Tissue Transfer

Many patients dream of reducing their abdominal or gluteal fat tissue and, in the same procedure, enlarging their breasts without the need for implants and their related problems. Following this demand, a new “natural” alternative to breast augmentation with autogenous tissue is presented. Since 1993, 16 patients have undergone either unilateral or bilateral breast augmentation with free fat transfer. These 20 augmentation mammaplasties consisted of nine deep inferior epigastric perforator flaps, eight superior gluteal artery perforator flaps, and three superficial inferior epigastric artery flaps. The postoperative results were judged aesthetically by independent examiners and by the patients according to Netscher’s score. The additional operations for final shaping of the breasts and the postoperative complications at the donor and recipient sites are reported. The augmented breasts improved the aesthetic proportions more than 100 percent. All flaps survived, and except for minor postoperative complications such as small areas of wound dehiscence, the breasts could be shaped aesthetically in a second-stage procedure several weeks later. Breast augmentation with autogenous tissue offers a natural alternative to alloplastic augmentation mammaplasty.
PENGARUH ROA, FIRM SIZE DAN NPM TERHADAP RETURN SAHAM PADA PERUSAHAAN SEMEN

The objective of the investment is to invest in the form of stock in the capital market which is to obtain maximum return with low risk. Many factors are able to influence the stock return. This research is meant to test the influence of Return on Asset, Firm Size and Net Profit Margin to the stock return. The object of the research is the cement companies which have gone public in Indonesia Stock Exchange and the research observation from 2010 tol 2013. The sample collection technique has been done by using purposive sampling with the criteria i.e.: (1) the cement company which has been listed in Indonesia Stock Exchange in 2010-2013 periods. (2) The cement company has published their financial statement in 2010-2013 periods. 3 cement companies have been obtained from these criteria and they have become the research samples. The analysis technique has been done by using multiple linear regressions analysis. The hypothesis test result in this research is shows that Firm Size variable has significant influence to the return meanwhile Return on Asset variable and Net Profit Margin variable does not have any influence to the stock return. Keywords:stock return, return on assets, firm size, net profit margin.
Primary Murine Small Intestinal Epithelial Cells, Maintained in Long-Term Culture, Are Susceptible to Rotavirus Infection

ABSTRACT We describe a method for long-term culture of primary small intestinal epithelial cells (IEC) from suckling mice. IEC were digested from intestinal fragments as small intact units of epithelium (organoids) by using collagenase and dispase. IEC proliferated from organoids on a basement-membrane-coated culture surface and remained viable for 3 weeks. Cultured IEC had the morphologic and functional characteristics of immature enterocytes, notably sustained expression of cytokeratin and alkaline phosphatase. Few mesenchymal cells were present in the IEC cultures. IEC were also cultured from adult BALB/c mice and expressed major histocompatibility complex (MHC) class II antigens for at least 48 h in vitro. Primary IEC supported the growth of rhesus rotavirus (RRV) to a greater extent than a murine small intestinal cell line, m-ICcl2. Cell-culture-adapted murine rotavirus strain EDIM infected primary IEC and m-ICcl2 cells to a lesser extent than RRV. Wild-type EDIM did not infect either cell type. Long-term culture of primary murine small intestinal epithelial cells provides a method to study (i) virus-cell interactions, (ii) the capacity of IEC to act as antigen-presenting cells using a wide variety of MHC haplotypes, and (iii) IEC biology.
Predictive value of pulmonary function tests before marrow transplantation.

OBJECTIVE To evaluate association between pulmonary function tests (PFT) performed before marrow transplantation and mortality after transplant. SETTING A single marrow transplantation research center. DESIGN Case-series review. PATIENTS All patients between January 1986 and July 1990 who performed PFT before a first marrow transplant for the treatment of malignancy (n = 1297) were included in study. Six hundred twenty-eight (48 percent) patients had morphologically or cytologically active malignant neoplasms at the time of transplant. Allogeneic marrow transplants were performed in 1,056 (82 percent) and autologous transplants were performed in 235 (18 percent). Three hundred seventy-two (29 percent) patients received HLA-nonidentical donor marrow. Graft-vs-host disease prophylaxis was methotrexate and cyclosporine in 901 (85 percent) of the allogeneic recipients. Most patients were prepared for transplant with total body irradiation in addition to cyclophosphamide (n = 1,059, 82 percent), while 230 (18 percent) were conditioned with busulfan and cyclophosphamide. MEASUREMENTS AND MAIN RESULTS The overall mortality during the first six months of follow-up was 44 percent. Respiratory failure requiring assisted mechanical ventilation occurred in 23 percent (n = 298) of patients. A proportional hazards regression analysis was used to evaluate the predictive value of PFT results: (1) FEV1/FVC; (2) P(A-a)O2 gradient; (3) TLC; and (4) Dcosb (the latter two presented a percent of predicted). Abnormalities in TLC, Dcosb, and P(A-a)O2 were found to be significantly associated with death in univariate analysis. Next, the value of PFT for prediction above and beyond other baseline covariates was evaluated by first using the step-up stepwise proportional hazards model to select predictive variables other than the PFT variables. Then each of the PFT variables was tested in the presence of these other variables. The factors of age, primary diagnosis, relapse status, and donor-recipient HLA nonidentity were found to be risks for death and were entered as covariates. Each of the variables of PFT were entered stepwise into the model. Dcosb (RR = 1.43 for a value 80 percent of predicted) and P(A-a)O2 (RR = 1.28 for a value of 20 mm Hg) were found to be independent risk factors for death. The use of assisted mechanical ventilation appeared to increase proportionately with the increase in mortality among patients with abnormal Dcosb or P(A-a)O2. CONCLUSIONS Decreased Dcosb and increased P(A-a)O2 gradient before marrow transplant carry significantly increased risk of death after marrow transplant. The risk associated with abnormal PFT is less than that associated with other recognized risk factors, such as relapse status and donor-recipient HLA nonidentity. Respiratory failure does not appear to account entirely for the increased mortality associated with abnormal pretransplant PFT. PFT should be used in assessing fully the risks to recipients of marrow transplants for malignancy, but should not be used as absolute exclusion criteria for transplantation.
Oscillatory activity is not evident in the primate temporal visual cortex with static stimuli

It has been suggested in studies in the visual system of anaesthetized cats that oscillatory activity with a frequency of 40-60 Hz occurs during the presentation of moving visual stimuli and reflects a synchronization process between neurons that could implement the binding together of related neurons into different sets. We found no evidence for such oscillations in the inferior temporal visual cortex and related areas of awake macaques fixating effective static visual stimuli, which for the neurons analysed were faces. We put forward the possibility that temporal synchronization between neurons to implement binding may not be generally used in the visual system as a solution to the binding problem, at least when static objects are being processed and recognised in higher parts of the visual system.
A high baseline HBV load and antiviral therapy affect the survival of patients with advanced HBV‐related HCC treated with sorafenib

Although a high viral load is an independent risk factor for recurrence of hepatitis B virus (HBV)‐related hepatocellular carcinoma (HCC) after surgery, the prognostic impact of viral load on advanced HCC is unclear. This study investigated the impact of baseline HBV load and antiviral therapy on survival of patients with advanced HCC treated with sorafenib.
The Effect of Organizational Culture, Leadership Style, and Functional Position on Organizational Commitment and Their Impact on the Performance of Internal Auditors in Aceh, Indonesia

This study aims at empirically examining the influence of the organizational culture, leadership style, and functional position of an auditor on organizational commitment and their impact on the performance of government internal auditors in Aceh, Indonesia. All 183 of the governmental internal auditors at the district level within the Province of Aceh, Indonesia, were investigated. Data, which are gathered by distributing questionnaires to the entire population, are then analysed by the Structural Equation Modelling (SEM) technique. The study found that organizational culture, leadership style, and functional auditor have affected the performance of the governmental internal auditor either directly or indirectly through organizational commitment. Keywords: Organizational Culture, Leadership Style, Functional Auditor, Organizational Commitment, Internal Auditor Performance.
Instruction of Compression Therapy by Means of Interface Pressure Measurement

Background. Compression therapy of the leg is the cornerstone in the conservative treatment of venous ulcers. The application of compression bandages, however, is largely a matter of personal experience. Objective. To evaluate the interface pressure under compression bandages and to improve the technique. Methods. Six courses on wound healing with 24–28 participants as well as individual training at our hospital were provided. Interface pressure at the distal medial calf was measured using a simple, but accurate pressure sensor that was built for this purpose (accuracy: ±3 mmHg). Results. During the wound healing courses, the absolute difference from the target pressure of 35–45 mmHg improved from 8.4 mmHg (95% CI 0.0–34.1) to 3.5 mmHg (95% CI 0.0–14.0) (P = .0001). After four sessions, interface pressures greater than 60 mmHg were avoided. During individual training, even nurses with everyday experience in compression therapy improved their accuracy. Conclusion. There is a need for objective measurement of interface pressure in the teaching of compression therapy with bandages. The principles can be taught during a few exercises. However, repeated practice over a longer period of time is necessary to reach a certain accuracy.