Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of aspirin on trophoblastic invasion in women with abnormal uterine artery Doppler at 11–14 weeks: a randomized controlled study

Defective trophoblastic invasion is a key feature in many cases of pre‐eclampsia (PE). Uterine artery (UtA) Doppler is a validated non‐invasive proxy for trophoblastic invasion. The aim of this study was to explore whether low‐dose aspirin, administered from the first trimester, improves trophoblastic invasion, evaluated by UtA Doppler during the second and third trimesters in women defined as high risk by abnormal first‐trimester UtA Doppler.
The effects of sodium arsenite on the testis structure and sex hormones in vasectomised rats

Background: Sodium arsenite and/ or vasectomy may cause variation in sex hormones which affect pathophysiology of reproductive organs. Objective: The aim was to investigate the morphological changes in structure of testis and hormonal imbalance in bilateral Vasectomised rats treated with sodium arsenite. Materials and Methods: Four groups of rats: bilateral vasectomy + sodium arsenite, bilateral vasectomy, sham operated + sodium arsenite and sham operated only were considered, and 8 mg/kg/ day of sodium arsenite was given for 8 weeks to the rats. The total volume of testis, volume of interstitial tissue, volume of seminiferous tubules, diameter of seminiferous tubules and germinal epithelium thickness were evaluated using stereological methods. Hormones were also measured and the results were analyzed using one way ANOVA. Results: A significant reduction of total volume of testis (p<0.01), mean volume of seminiferous tubules (p<0.002) as well as germinal epithelium thickness (p<0.05) in both vasectomy + sodium arsenite and vasectomy rats was seen compared to sham operated only. In addition a significant reduction of testosterone was observed in vasectomy + sodium arsenite group when compared to the other groups (p<0.001). LH level decreased significantly in vasectomy + sodium arsenite when compared to sham operated ones (p<0.05). Conclusion: Vasectomy and treatment with sodium arsenite affect the structure of testis with respect to its volume, volume of seminiferous tubules and thickness of germinal epithelium, which may be due to variation of LH and testosterone level in the rats.
Aggressively scaled (0.143 /spl mu/m/sup 2/) 6T-SRAM cell for the 32 nm node and beyond

A 0.143 /spl mu/m/sup 2/ 6T-SRAM cell has been fabricated using a planar SOI technology with mixed electron-beam and optical lithography. This is the smallest functional 6T-SRAM cell ever reported - consistent with cell areas beyond the 32 nm technology node. Enabling process features include a 25 nm SOI layer, shallow trench isolation (STI), 45 nm physical gates with ultra-narrow 15 nm spacers, novel extremely thin cobalt disilicide, 50 nm tungsten plug contacts, and damascene copper interconnects. Device threshold voltages (V/sub T/) and cell beta ratio (/spl beta/) are optimized for cell stability at these aggressive ground rules. The 0.143 /spl mu/m/sup 2/ 6T-SRAM cell exhibits a static noise margin (SNM) of 148 mV at V/sup DD/=1.0 V.
Robust named entity disambiguation with random walks

Named Entity Disambiguation is the task of assigning entities from a Knowledge Base to mentions of such entities in a textual document. This article presents two novel approaches guided by a natural notion of semantic similarity for the collective disambiguation of all entities mentioned in a document at the same time. We adopt a uniﬁed semantic representation for entities and documents—the probability distribution obtained from a random walk on a subgraph of the knowledge base—as well as lexical and statistical features commonly used for this task. The ﬁrst approach is an iterative and greedy approximation, while the second is based on learning-to-rank. Our experimental evaluation uses well-known benchmarks as well as new ones introduced here. We justify the need for these new benchmarks, and show that both our methods outperform the previous state-of-the-art by a wide margin.
Three Level Competencies of Entrepreneurial Team: Team Leader, Member Level and Team Level

This paper develops a conceptual model including three level competencies of entrepreneurial team and environment to comprehensively understand ET's new venture performance. We specify competencies of each level, including leader's individual-oriented and team-oriented competencies; member's individual competencies, member complementary competencies and balanced role distribution; team level's knowledge, skill and attitude. This paper also advances a series of corresponded propositions according to the model
Natural History of Glomus Jugulare

Objective To characterize clinical disease progression and radiologic growth in a series of observed, previously untreated, glomus jugulare tumors (GJT). Study Design Retrospective review. Setting Tertiary neurotologic referral center. Subjects and Methods All patients with primary GJTs that were observed without intervention for a minimum of 2 years. Primary outcome measures included progression of cranial neuropathy and/or radiologic growth. Results A total of 15 patients (80% female; median age, 69.6 years) with 16 GJTs met inclusion criteria. The most common indications for observation included advanced age (11; 73%) and patient preference (11; 73%). Cranial nerve function remained stable in most subjects over a median clinical follow-up period of 86.4 months. Among the 12 with serial imaging, 5 (42%) GJTs demonstrated radiologic growth, while 7 (58%) remained stable. The median growth rate of the 5 enlarging tumors using the maximum linear dimension was 0.8 mm/y (range, 0.6-1.6 mm/y) or 0.4 cm3/y (0.1-0.9 cm3/y) using volumetric analysis. There were no deaths attributable to tumor progression or treatment. Conclusion In an older subset of patients, we found that a significant number of GJTs do not grow after time of diagnosis and symptoms frequently remain stable for many years. Even with disease progression, most GJTs exhibit indolent growth with slowly progressive cranial neuropathy, affording satisfactory physiologic compensation in most patients. In the absence of brainstem compression or concern for malignancy, observation of GJTs is a viable initial management option for elderly patients.
An Evaluation of Antidepressants in Rheumatic Pain Conditions

In a randomized, double-blind, parallel study, fluoxetine and amitriptyline were compared with placebo in the treatment of chronic rheumatic pain. A total of 59 patients were evaluated during 4 wk of treatment and received 20 mg fluoxetine, 25 mg amitriptyline, or placebo daily. Pain intensity, pain relief, vital variables, and global evaluation were used to assess efficacy. To evaluate safety variables, the incidence of side effects was noted. Both amitriptyline and fluoxetine significantly reduced pain intensity compared with placebo. Similarly, pain relief was greater with both amitriptyline and fluoxetine than with placebo. At the end of the fourth week, fluoxetine was superior in efficacy to amitriptyline. The incidence of adverse effects was significantly greater with amitriptyline; dryness of the mouth was the most predominant side effect. We conclude that fluoxetine is an effective analgesic with fewer side effects. (Anesth Analg 1996;83:371-5)
Patient-related factors in rhinitis and asthma: the satisfaction with allergy treatment survey

Abstract Background: Patient satisfaction with the prescribed treatments represents a crucial issue that may have clinical relevance as it may significantly affect treatment compliance. We designed an observational study to evaluate the satisfaction level concerning different pharmacological treatments for allergic rhinitis (AR) and asthma in a real-life setting. Methods: The study was conducted in 21 allergy centres homogeneously distributed in Italy. Three hundred and one patients (46.8% males; 53.2% females; mean [SD] age, 33.1 [13.8] years) with AR and/or asthma were consecutively evaluated. Diagnosis, classification, symptom severity, and satisfaction degree (assessed by a questionnaire) were the parameters considered. Results: Only 33.5% of the AR patients were satisfied with the rhinitis treatments. Only 40.7% of the asthmatic patients were satisfied with the asthma treatments. Some factors associated with treatment dissatisfaction are as follows: female gender (odds ratio [OR] 2.36; p < 0.01), co-morbidity (OR 2.39; p < 0.05), rhinitis severity (OR 1.39; p < 0.05), asthma severity (OR 2.04; p < 0.05), and antihistamine use (OR 2.53); however, the use of bronchodilators had a favourable impact (OR 0.28; p < 0.05). The relatively low number of subjects prevented performing stratification of patients by treatment classes. Conclusion: The findings of this real-life study strengthen the concept that AR is particularly troublesome and that most allergic patients suffering from both rhinitis and asthma are dissatisfied with prescribed drugs.
A single point mutation of Ala-25 to Asp in the 14,000-Mr envelope protein of vaccinia virus induces a size change that leads to the small plaque size phenotype of the virus

The molecular defect responsible for a structural and functional abnormality of the 14,000-molecular-weight (14K) envelope protein of vaccinia virus has been identified. Through DNA sequence analysis of the entire 14K gene from wild-type vaccinia virus and three vaccinia virus mutants, a single base change of C to A was found that resulted in the substitution of Asp for Ala-25. This mutation is responsible for protein size abnormality, as documented by cell-free translation in a rabbit reticulocyte lysate of in vitro mRNA transcripts. In addition, through marker rescue experiments we show that this mutation is responsible for the small plaque size phenotype of vaccinia virus mutants. The structural consequence of the point mutation is a possible turn in an alpha-helix domain with destabilization of a hydrophobic interaction at the N terminus, resulting in monomers and trimers of vaccinia virus 14K protein with decreased electrophoretic mobilities. The functional consequence of the point mutation is a reduction in virulence of the virus.
Production of leukemia inhibitory factor mRNA and protein by malignant and immortalized bone cells

Leukemia inhibitory factor (LIF) is a recently characterized glycoprotein with complex biologic activities on bone cells. We tested various rodent and human immortalized and malignant bone cell lines and primary osteoblast‐enriched cell cultures from fetal rat calvarial digests for expression of LIF mRNA and LIF protein. Both human and rodent immortalized and malignant cells expressed a single 4.4 kb mRNA transcript that hybridized to a human LIF cDNA probe in Northern blots. LIF mRNA was undetectable in unstimulated rodent osteoblast‐like cells lines MC3T3‐E1 and Pyla. However, treatment with LPS (10 μg/ml), TGF‐β (1 ng/ml), TNF‐α (100 ng/ml) or inhibitors of protein synthesis (cycloheximide, emetine, puromycin, and anisomycin) induced the expression of LIF message in these cells. In contrast, primary osteoblast‐enriched cells did not express LIF mRNA in Northern blot assays either constitutively or after treatment with TNF‐α or cycloheximide. The human osteosarcoma cells lines U‐2 OS and Saos‐2 constitutively expressed LIF mRNA and did not respond to LPS treatment. However, phorbol myristate acetate (PMA), an activator of protein kinase C, was a potent stimulator of LIF message in Saos‐2 but not U‐2 OS cells. The effects of PMA (0.5 ng/ml) on LIF mRNA in Saos‐2 cells were detectable at 1 h and maximal at 6 h. TNF‐α (100 ng/ml) and inhibitors of protein synthesis also increased LIF mRNA in both Saos‐2 and U‐2 OS cells. LIF protein was also detected constitutively in the conditioned medium from both Saos and U‐2 OS cells. In addition, TNF (100 ng/ml) stimulated the release of LIF protein from both these cells and PMA (2.5 ng/ml) stimulated LIF protein in Saos‐2 cells. These results show that several different human malignant and rodent immortalized clonal bone cell lines can express and regulate steady‐state LIF mRNA levels and produce LIF protein but that primary cultures of fetal rat osteoblastic cells do not express this cytokine. Hence, LIF may regulate malignant osteogenic cell growth and function in bone but may not be an important regulator of normal bone metabolism.
Detection of tetracycline resistance determinants in pig isolates from three herds with different histories of antimicrobial agent exposure

A total of 114 gram-negative fecal isolates from domestic pigs in herds with different histories of antimicrobial agent exposure were screened for the presence of plasmid DNA and specific tetracycline resistance determinants. More than 84% of the isolates harbored plasmid DNA, which ranged in size from 2.1 to 186 kb. A total of 78 isolates (68.4%) were resistant to tetracycline at concentrations greater than 4 micrograms/ml. Plasmid DNAs from about 56% of the tetracycline-resistant isolates hybridized with DNA probes for class A, B, C, and D tetracycline resistance determinants. The class B determinant was the most common determinant (35% of the isolates), followed by the class C determinant (12%) and the class A determinant (1%). About 9% of the isolates contained two determinants on plasmids. None of the plasmids from isolates hybridized with the class D determinant probe. The class C determinant was the most prevalent determinant on plasmids in isolates from pigs not exposed to antimicrobial agents for more than 146 months, while the class B determinant was more prevalent on plasmids in isolates from pigs exposed to either subtherapeutic or therapeutic levels of antimicrobial agents. Most tetracycline resistance determinants were localized on plasmids which were more than 30 kb long. A great number of wild-type tetracycline-resistant Escherichia coli strains were found with the class E determinant on their chromosomes. This study revealed a high prevalence of tetracycline resistance determinants in the fecal flora of pig herds whether or not they were fed with antibiotics.
Interleukin-2 is found in the synovium of psoriatic arthritis and spondyloarthritis, not in rheumatoid arthritis.

Objective of this project was to determine whether synovial expression of interleukin-2 (IL-2) in arthritis is a disease-specific phenomenon. Immunohistological examination of needle biopsies from 7 rheumatoid arthritis (RA) patients never exposed to disease modifying antirheumatic drugs (DMARDs), 13 RA patients on DMARDs, 4 patients with seronegative spondyloarthritis (SpA), and 5 psoriatic arthritis (PsA) patients. Biopsies were either snap-frozen immediately or cultured for 48 hr, with and without phytohaemagglutinin (PHA) prior to APAAP staining. In snap-frozen biopsies, IL-2 was detected in none of 18 RA samples with significant T cell infiltrates. In contrast, IL-2 was seen in 7/9 PsA/SpA samples. After culture without PHA, IL-2 was detected in 0/14 RA and 5/6 PsA/SpA samples; with PHA, IL-2 was present in 1/14 RA and 2/2 PsA/SPA samples. Synovial IL-2 protein expression appears to distinguish between RA (absent) and PsA/SpA (present). This may reflect a difference in pathophysiology between these diseases.
Changes in breathing, electrocortical and muscle activity in unanaesthetized fetal lambs with age.

Electrocortical and electro‐ocular activity, breathing movements and nuchal muscle activity were recorded continuously in the unanaesthetized lamb in utero (95‐135 days). Electrocortical activity was recorded simultaneously from various sites. The bi‐parietal electrocorticogram gave the clearest differentiation between high‐ and low‐voltage activity. The onset of cortical differentiation from 110 days gestation was attributed to the superimposition of high‐voltage electrocortical activity at 3‐10 Hz on existing low‐voltage activity. Three distinct patterns in the relationships between electrocortical activity, ocular activity breathing movements and nuchal muscle activity were observed at 95‐106, 107‐114 and 120‐135 days. Isocapnic hypoxia caused a diminution in fetal breathing from 95‐135 days gestation, quantitatively greater near term. After cortical differentiation, hypoxia caused the appearance of high‐voltage activity within 4 min, if low‐voltage electrocortical activity was present initially. The relationship, changing with age, between electrocortical activity, breathing movements, ocular and nuchal muscle activity is discussed.
How Experience-Driven Community Identification Generates Trust and Engagement

Purpose – The purpose of this paper is to develop a conceptual model of how technology‐enabled virtual experiences contribute to community members' online trust and engagement through inducing their community identification. It also seeks to examine two types of social influence in the virtual community: within‐community normative pressure and normative pressure from outside the community.Design/methodology/approach – The authors employed the structural equation modelling approach to estimate a conceptual model using survey data from participants in the World of Warcraft online game community.Findings – The results mainly supported the hypotheses. It was shown that three types of experience could influence community members' engaging behaviour through an increase in community identification and community trust. More importantly it was found that normative pressure from outside the community exhibits a significant and inverted U‐shaped relationship with online community engagement, while within‐community n.
Salivary flow and dental caries in Brazilian youth with type 1 diabetes mellitus.

BACKGROUND Although type 1 diabetes mellitus (T1DM) has a significant impact on oral health, its association with dental caries is yet not clear. AIM The aim of this study was to evaluate the salivary flow rate and caries in Brazilian youth with type 1 diabetes mellitus. SETTING AND DESIGN A Cross-sectional study was performed in a tertiary university hospital. MATERIALS AND METHODS Fifty-one age matched subjects suffering from type 1 diabetes mellitus were selected for the study and evaluated for the following: salivary flow rate, number of decayed, missing and filled tooth in permanent dentition (DMF-T) and decayed, extracted, filled tooth index in the deciduous dentition (def-t); visible plaque index (VPI) and gingival bleeding index (GBI). STATISTICS AND ANALYSIS: The t test was utilized when the variables showed normal distribution. The Mann-Whitney test was utilized for comparing non-normal variables. Kolmorgorov-Smirnov test was used to assess the normality assumption. The differences were considered significant when P < 0.05. RESULTS The age and gender distribution of patients and controls was 11.3 ± 3.4 years (56% males) and 11.9 ± 3.4 years (37% males). The mean glycated hemoglobin value in the diabetics was 9.7 ± 1.9%. Salivary flow rate was lower in the diabetic patients as compared to controls (P = 0.02). No differences were found in the DMF-T/def-t indices of diabetic and non-diabetic patients (P = 0.43/0.14). VPI was similar in both the groups (P = 0.15). GBI was higher in the diabetics (8.1 vs. 5.18; P = 0.11). There were no differences in the dental caries experience and dental plaque in the two groups. CONCLUSION The lower salivary flow rate in diabetics could have been related to their higher GBI. The higher GBI in the diabetics is a matter of concern in the diabetics and is a sign for higher chances of developing periodontal problems.
WINTER PHILOPATRY OF HARLEQUIN DUCKS IN PRINCE WILLIAM SOUND, ALASKA

Abstract We used capture-mark-recapture data to assess winter philopatry by Harlequin Ducks (Histrionicus histrionicus) in Prince William Sound, Alaska, during winters 1995–1997 and 2000–2001. Philopatry was quantified using homing rates, which were estimated as the proportion of birds recaptured at their original site out of all recaptured birds. Between-year homing rates of 0.95 (95% CI: 0.87–1.00) and 1.00 (0.92–1.00) were estimated for females and males, respectively, at three locations on Montague Island. Similar homing rates were measured in western Prince William Sound, where estimates were 0.92 (0.80–0.98) for females and 0.96 (0.79–1.00) for males, with a scale of detected movements for all recapture birds ranging from 3–52 km. Our results indicate that wintering aggregations may be demographically independent at a much finer spatial scale than genetic data indicate, and that conservation efforts should recognize this degree of demographic separation among population segments. Filopatría Invernal de Histrionicus histrionicus en Prince William Sound, Alaska Resumen. Utilizamos datos de marcaje y recaptura para determinar la filopatría de Histrionicus histrionicus en Prince William Sound, Alaska, durante los inviernos de 1995–1997 y 2000–2001. La filopatría fue cuantificada utilizando la tasa de retorno, estimada a partir de la proporción del total de aves capturadas que se recapturaron en su sitio original. Las tasas de retorno entre años, estimadas en tres localidades en la isla Montague, fueron de 0.95 (95% IC: 0.87–1.00) y 1.00 (0.92–1.00) para hembras y machos, respectivamente. En Prince William Sound se midieron tasas de retorno similares, donde las estimaciones fueron 0.92 (0.80– 0.98) para las hembras y 0.96 (0.79–1.00) para los machos, y para todas las aves recapturadas se detectó una escala de movimiento entre 3 y 52 km. Nuestros resultados indican que las agrupaciones de invierno pueden ser demográficamente independientes a una escala espacial mucho más fina de lo que los datos genéticos indican, y que los esfuerzos de conservación deberían reconocer este grado de separación demográ fica entre segmentos de poblaciones.
How Authoritarian Leadership and Renqing Orientation Improve Tacit Knowledge Sharing

Following an indigenous approach and fairness theory, we develop a theoretical model to investigate when and how authoritarian leadership will improve tacit knowledge sharing (KS). Drawing on survey data from 309 Chinese employees, we examine whether authoritarian leadership will affect procedural fairness (PF) perception and interactional fairness (IF) perception, which in turn, will affect tacit KS; and examine whether leader renqing orientation (LRO) will moderate these mediation processes. Our data demonstrate that authoritarian leadership is negatively related to IF perception, which is positively related to tacit KS. Moreover, authoritarian leadership significantly increases tacit KS intention through PF perception only when LRO is high. Authoritarian leadership significantly decreases tacit KS intention through PF perception and IF perception only when LRO is low. Theoretical and practical implications are discussed.
Elemental Analysis of Ten Sudanese Medicinal Plants Using X-ray Fluorescence

Eleven elements (K, Ca, Zn, Cu, Fe, Mn, Cr, Ni, Br, Rb and Zr) were determined by using Energy Dispersive X-ray Fluorescence (EDXRF) in selected Sudanese medicinal plants namely; Ambrosia maritime L. , Balanites aegyptiaca (L.) Del. , Cymbopogon proximus (Hochst. ex A. Rich.) Stapf, Grewia tenax (Forssk.) Fiori, Hydnora johannis Becca, Lepidium sativum L. , Nauclea latifolia Smith, Peperomia pellucida L. , Senna obtusifolia (L.) Irwin & Barneby and Tamarix aphylla (L.) Karsten. G. tenax has the highest concentration of Ca (8107 ppm), Br (33 ppm), Rb (19.9 ppm), Zn (18.11 ppm) and Cu (15.9 ppm). The highest concentration of K (15451 ppm) and Fe (1426 ppm) was found in H. johannis. The highest concentration of Cr (13.10 ppm) and Ni (7.6 ppm) was found in C. proximus. A. maritima and B. aegyptiaca had the highest concentration of Mn (10.6 ppm) and Zr (8.2 ppm) respectively. Such information could be helpful in standardization of herbal products since the Sudanese medicinal plants play an important role in maintenance of human health.