Miracle-dz/UniFAR-FTUs huggingface dataset:
Individualizing Acceleration in English Premier League Academy Soccer Players

Abstract Abbott, W, Brickley, G, Smeeton, NJ, and Mills, S. Individualizing acceleration in English Premier League academy soccer players. J Strength Cond Res 32(12): 3512–3519, 2018—Global thresholds are typically used to band acceleration dependent on intensity. However, global thresholds do not account for variation in individual capacities, failing to quantify true intensity of acceleration. Previous research has investigated discrepancies in high-speed distance produced using global and individual speed thresholds, not yet investigated for acceleration. The current aim was to investigate discrepancies between global and individual thresholds when quantifying acceleration tasks. Acceleration data were recorded for 31 professional soccer players, using 10-Hz global positioning systems devices. Distances traveled performing low-, moderate-, and high-intensity acceleration were calculated for athletes using global and individual thresholds. Global acceleration thresholds for low-, moderate-, and high-intensity acceleration were classified as 1–2, 2–3, and >3 m·s−2, respectively, with individual thresholds classified as 25–50%, 50–75%, and >75% of maximum acceleration, respectively. Athletes were grouped low (LO), medium (ME), or high (HI) maximum accelerative capacity, determined using 3 maximal 40-m linear sprints. Two-way mixed-design analyses of variance were used to analyze differences in acceleration distances produced between analysis methods and athlete groups. No significant differences were identified between analysis methods for LO. For ME, no significant differences were demonstrated for low intensity. Moderate- and high-intensity acceleration distances were significantly higher for global compared with individual analysis method (p < 0.01). For HI, significantly higher acceleration distances were produced for all acceleration intensities using global thresholds (p < 0.01). Significant differences identified between analysis methods suggest practitioners must apply caution when using global thresholds. Global thresholds do not account for individual capacities and may provide an inaccurate representation of relative intensity of acceleration tasks.
Associations of TCF7L2 gene polymorphisms with the risk of diabetic nephropathy

Abstract The aim of the study was to explore the correlation between rs7903146 and rs290487 polymorphisms in transcription factor 7-like 2 (TCF7L2) gene and diabetic nephropathy (DN) in Chinese Han population. Polymerase chain reaction–restriction fragment length polymorphism was used to determine genotypes of TCF7L2 polymorphisms in 90 patients with DN and 96 diabetes patients without DN. The linkage disequilibrium (LD) and haplotype analysis were performed with haploview software. Hardy–Weinberg equilibrium was assessed in the control group based on the genotype distributions of TCF7L2 polymorphisms. The genotype, allele, and haplotype distribution differences between the case and control groups were analyzed by chi-squared test, and odds ratio (OR) and 95% confidence interval (CI) were used to indicate the relative risk of DN. People carrying TT genotype of rs7903146 were more easily to be attacked by DN than CC genotype carriers (P = .02, OR = 4.26, 95% CI = 1.12–16.24). Meanwhile, T allele also showed 1.85 times risk to suffer from DN compared with C allele (OR = 1.85, 95% CI = 1.02–3.10). However, there was no significant difference in genotypes and alleles frequencies of rs290487 between 2 groups. The strong LD existed between the 2 single nucleotide polymorphisms and haplotype T–T (rs7903146–rs290487) increased the susceptibility to DN (OR = 2.63, 95% CI = 1.31–5.25). TCF7L2 rs7903146 polymorphism may be associated with the susceptibility to DN in Chinese Han population, but rs290487 is not. Additionally, haplotype is also a risk factor for DN.
Endovascular retrograde approach may be a better option for acute tandem occlusions stroke

Objective The endovascular treatment strategy for acute tandem occlusion stroke is challenging, and controversy exists regarding which lesion should be treated first. This study addresses the uncertainty regarding the priority choice for thrombectomy in acute anterior circulation tandem occlusion stroke. Methods We analysed the clinical and angiographic data of tandem stroke patients who underwent interventional therapy from the endovAsCular Treatment of acUte Anterior circuLation ischaemic stroke (ACTUAL) registry. Recanalisation was assessed according to the modified thrombolysis in cerebral infarction score. Clinical outcome was evaluated at 90 days using the modified Rankin scale score. Results Sixty tandem occlusion stroke patients were enrolled. Thirty-one (51.7%) patients received anterograde therapy, while 29 (48.3%) patients underwent the retrograde approach. Successful recanalisation (modified thrombolysis in cerebral infarction score 2b–3) occurred in 78.3% (47/60) of patients, and 50.0% (30/60) of patients achieved a modified Rankin scale score of 0–2 at 90 days. Patients undergoing the retrograde approach spent less time in distal occlusion recanalisation (125 (86–167) vs. 95 (74–122) minutes; P = 0.04) and achieved better functional outcomes at 90 days (69.0% (20/29) vs. 32.3% (10/31); P = 0.004) than patients who received anterograde therapy. The retrograde approach was associated with favourable clinical outcomes (odds ratio 0.21; 95% confidence interval 0.07–0.64; P = 0.006). Conclusion For acute tandem occlusion stroke, favourable outcomes were better in patients undergoing retrograde therapy than in patients who received the anterograde approach. Future randomised trials are warranted to determine the optimal treatment.
Possible Mechanisms for The Effects of Calcium Deficiency on Male Infertility

Calcium (Ca) is a significant element that acts as an intracellular second messenger. It is necessary for many physi- ological processes in spermatozoa including spermatogenesis, sperm motility, capacitation, acrosome reaction and fertilization. Although influences of Ca deficiency on sperm function and male infertility have been widely studied, mechanisms for these abnormalities are not well considered. Poor sperm motility, impairment of chemotaxis, capaci- tation, acrosome reaction and steroidogenesis are the major mechanisms by which Ca deficiency induces male infertil- ity. Therefore, an optimal seminal Ca concentration is required to strengthen sperm function and all steps leading to successful fertilization. Furthermore, identification of these mechanisms provides valuable information regarding the mechanisms of Ca deficiency on male reproductive system and the way for developing a better clinical approach. In this review, we aim to discuss the proposed cellular and molecular mechanisms of Ca deficiency on male reproductive system, sperm function and male fertility. Also we will discuss the valuable information currently available for the roles of Ca in male reproduction.
A systematic review and meta-analysis

Objective: It is still controversial whether patients with clinical T2N0M0 (cT2N0M0) esophageal cancer are treated with induction therapy. The aim of this study was to determine the effect of induction therapy on cT2N0M0 esophageal cancer. Methods and materials: We searched PubMed, Embase, the Cochrane Library, and Medline databases from inception up to May 1, 2017. This meta-analysis was performed to compare odds ratios (OR) for 5-year overall survival (OS), pathologically understaged and overstaged after esophagectomy. Results: Eight retrospective studies of 2646 patients were included in the meta-analysis. Data showed that no statistically significant difference in 5-year over survival was observed between induction therapy group and direct operation group. The pooled OR and 95% confidence interval (CI) for 5-year OS were 0.92 (95% CI=0.72–1.18; P= .52). Whereas, compared with induction therapy group, direct operation group had more pathologically understaged and less overstaged after esophagectomy. Conclusions: Currentclinical staging for T2N0M0 esophageal carcinoma remains inaccurate. In this study, we found that direct operation group had more pathologically understaged and less overstaged after esophagectomy compared with induction therapy group. Induction therapy could degrade the tumor staging but not improve the patient’s survival. Abbreviations: CI = confidence interval, cT2N0M0 = clinical T2N0M0, CRT = chemoradiotherapy, OR = odds ratios, OS = overall survival, pTNM = pathological TNM.
Amygdala subnuclei and healthy cognitive aging

Amygdala is a group of nuclei involved in the neural circuits of fear, reward learning, and stress. The main goal of this magnetic resonance imaging (MRI) study was to investigate the relationship between age and the amygdala subnuclei volumes in a large cohort of healthy individuals. Our second goal was to determine effects of the apolipoprotein E (APOE) and brain‐derived neurotrophic factor (BDNF) polymorphisms on the amygdala structure. One hundred and twenty‐six healthy participants (18–85 years old) were recruited for this study. MRI datasets were acquired on a 4.7 T system. Amygdala was manually segmented into five major subdivisions (lateral, basal, accessory basal nuclei, and cortical, and centromedial groups). The BDNF (methionine and homozygous valine) and APOE genotypes (ε2, homozygous ε3, and ε4) were obtained using single nucleotide polymorphisms. We found significant nonlinear negative associations between age and the total amygdala and its lateral, basal, and accessory basal nuclei volumes, while the cortical amygdala showed a trend. These age‐related associations were found only in males but not in females. Centromedial amygdala did not show any relationship with age. We did not observe any statistically significant effects of APOE and BDNF polymorphisms on the amygdala subnuclei volumes. In contrast to APOE ε2 allele carriers, both older APOE ε4 and ε3 allele carriers had smaller lateral, basal, accessory basal nuclei volumes compared to their younger counterparts. This study indicates that amygdala subnuclei might be nonuniformly affected by aging and that age‐related association might be gender specific.
Psychiatric morbidity in the male sentenced Irish prisons population

Abstract Background: This is the first epidemiologically representative cross-sectional study of psychiatric morbidity using research diagnostic instruments in sentenced prisoners in Ireland. Objective: To estimate the prevalence of psychiatric morbidity and psychiatric service requirements. Method: We interviewed 340 men serving a fixed sentence (14.6% of total) and 98 men serving a life sentence (82% of total). Prisoners were drawn from 15 different prisons using a random stratified sampling method. Mental illness and substance misuse was measured using the SADS-L, SODQ and a structured interview to generate ICD-10-DCR diagnoses. Results: We found a high prevalence of mental illness. Our six month prevalence for psychosis (2.7%) was similar to an international meta-analysis. We found a significantly higher prevalence of psychosis in life sentenced prisoners (6.1%) compared to fixed sentenced prisoners (1.8%). Drugs and alcohol problems were very prevalent. Conclusions: Using the six month prevalence figures found for psychosis, we estimate that there are approximately 79 sentenced male prisoners with a severe mental illness who would require treatment in hospital additional to current provision. We discuss the relationship between drug availability and the prevalence of severe mental illnesses in prisons.
Base excess is superior to lactate-levels in prediction of ICU mortality after cardiac surgery

Introduction Cardiac surgery with the use of cardiopulmonary bypass is known to induce distinct metabolic changes. Respective changes in acid-base status including increased systemic lactate levels were previously related to clinical outcomes, but data remain controversial. Therefore, we aim to investigate the relevance of lactate and base excess (BE) levels on ICU-mortality in patients admitted to the ICU after cardiac surgery. Materials and methods Perioperative data of patients treated in a tertiary care academic center admitted to the ICU after on-pump surgery were analyzed in a retrospective fashion. Receiver operation characteristic (ROC) curves were constructed for admission lactate-levels and BE with calculation of optimal cut-off values to predict ICU mortality. Univariate followed by multivariate regression models were constructed to identify potential outcome-relevant indices. Results Data from 1,058 patients were included in the analysis. Area under the curves for prediction of ICU mortality were 0.79 for lactate levels at ICU admission (sensitivity 61.9%/ specificity 87.5%; optimal cut-off level 3.9mmol/l), and 0.7 for BE (sensitivity 52.4%/ specificity 93.8%, optimal cut-off level -6.7), respectively. Multivariate regression identified BE < -6.7 as the single metabolic predictor of ICU-mortality (HR 4.78, 95%-CI 1.4–16.33, p = 0.01). Explorative subgroup analyses revealed that the combination of lactate ≤3.9mmol/l and BE ≤ -6.7 has stronger impact on mortality than a combination of lactate of >3.9mmol/l and BE > -6.7 (HR 2.56, 95%-CI 0.18–37.17). Conclusions At ICU-admission, severely reduced BE appears superior to hyperlactatemia with regard to prediction of ICU-mortality in patients after cardiac surgery.
Hospital Readmission Risk for Patients with Self‐Reported Hearing Loss and Communication Trouble

We studied participants in the Medicare Current Beneficiary Survey (MCBS), a nationally representative rotating panel survey. Individuals who responded between 2010 and 2013, were not institutionalized, were aged 65 and older, and had at least one inpatient claim at an acute care hospital were potentially eligible for the analysis. Index hospitalizations were identified using criteria from the Centers for Medicare and Medicaid Services (CMS) all-cause readmission program: no transition to a health maintenance organization plan within 30 days of discharge, no death in the hospital or within 30 days of discharge, no same-day transfer to another acute care facility, and no discharge against medical advice. Readmissions were admissions to an acute care hospital within 30 days of index discharge. Trouble communicating was assessed according to responses to two survey questions: Which describes your hearing (with a hearing aid): no trouble hearing, a little trouble, a lot of trouble, or deaf? and How much trouble do you have communicating with your doctor or other medical personnel because of your difficulty hearing: no
Comparative Evaluation of Retention, Cariostatic Effect and Discoloration of Conventional and Hydrophilic Sealants - A Single Blinded Randomized Split Mouth Clinical Trial

Introduction: Pit and fissures are approximately eight times vulnerable than the smooth surface caries lesion. Sealants are effective in preventing, arresting, and progression of pit-and-fissure occlusal caries lesions. The failure of sealant resin-based retention is mainly attributed to the moisture contamination. To overcome this drawback, UltraSeal XT® hydro, a moisture-friendly sealant, has been introduced. Aim: This study aimed to compare and evaluate the retention, cariostatic effect, and discoloration of conventional Clinpro™ 3M™ ESPE™ and hydrophilic UltraSeal XT® sealants among 12 to 15-year-old schoolchildren for 3 months. Materials and Methods: A single-blinded, randomized, split-mouth clinical trial was conducted among thirty schoolchildren aged 12–15 years. Sealants used in the present study were Group I – Clinpro™ and Group II – UltraSeal XT® hydro. Sealants were provided in the school by two operators based on the computer-generated random sequence and the study participants were evaluated after 3 months for sealant coverage, caries incidence, and discoloration using Color, Coverage and Caries sealant evaluation system. Sealant coverage between the two sealants was compared using Mann–Whitney U-test and Z-test for proportions. Results: A total of 47 teeth (78.3%) with UltraSeal XT® Hydro had the sealant covering in all the fissures compared to Clinpro™ 3M™ ESPE™ which was 46.7% (28 teeth) and the difference was observed to be statistically significant. Conclusion: Hydrophilic UltraSeal XT® Hydro yielded better sealant coverage (retention) compared to the conventional Clinpro™ 3M™ ESPE™. No difference was observed with regard to cariostatic effect and discoloration.
Devadasi and Their Intimate Partners: Dynamics of Relationship

Background: Devadasi practice is still prevalent in some parts of North Karnataka; most of the Devadasis get into sex work for their survival. During sex work, devadasis would get close to their customer, as they feel secure and emotionally satisfied. Objectives: The present study aims at understanding the Devadasi sex worker (DSW) and their intimate partners' (IPs) relationship and knowing the reasons for continuing the relationship even though they experience violence and abuse from their IP. Methods: Exploratory research design was adopted. Purposive sampling was used for the field visits. Data were gathered through personal interviews during field visits along with the counselors who were capacitated to deal with the relationship issues of DSWs and their IPs. Modified thematic analysis was used to analyze twenty field visit reports. Results: This study analyzed the quality and dynamics of the relationship between DSWs and their IP. DSWs and their IP define their relationship as “like marriage” without legal recognition. DSWs accept the violence from their IP as a symbol of love. Violence was identified as a key concern for the sex workers and is often acceptable in their relationship. Conclusion: The relationship between DSWs and their IPs needs to be understood before arriving at the care plan to deal with the relationship issues. There is an urgent need for developing an interventional model for the counselors and equip them to deal with the relationship issues of DSWs.
Ultrasound-guided Fine-needle Aspiration Cytology along with Clinical and Radiological Features in Predicting Thyroid Malignancy in Nodules ≥1 cm

Aims and Objectives: The aim of the study is to examine the adequacy and accuracy of ultrasound-guided fine-needle aspiration cytology (US-FNAC) in thyroid nodules ≥1 cm and to analyze the clinical, sonological, and cytological features in predicting thyroid malignancy. Materials and Methods: US-FNAC was done on 290 patients from December 2013 to December 2014 by the radiologist. The Thyroid Imaging Reporting and Data System (TIRADS) was used to record the sonological features. FNAC samples were reported by a dedicated cytopathologist. Accuracy was calculated by comparing US-FNAC, clinical features and ultrasound (US) features for those who had final histopathology till April 2017. Results: The adequacy of US-FNAC in this study was 80.2%. Thyroidectomy was performed in 128/290 (44.1%). The sensitivity and specificity of US-FNAC in this study is 83.9 and 76.3%, respectively, with a positive predictive value of 85.2%, negative predictive value of 74.4%, and an accuracy of 81% in predicting malignancy in thyroid nodules ≥1 cm. The malignancy rate in benign FNAC sample was 25% (10/40), and was 69% (8/13) in those with a follicular lesion of undetermined significance (FLUS). Around 80% of benign and 89% of FLUS had follicular variant of papillary carcinoma of thyroid (FVPTC). US-FNAC, a high TIRADS score, and US features such as marked hypoechogenicity, taller than wide, irregular margins, microcalcification, and clinical features, such as hard in consistency and significant cervical lymph nodes, were important in predicting malignancy (P < 0.001). Conclusions: The accuracy of US-FNAC in this study is 81%. The US-FNAC, a high TIRADS score, a hard thyroid nodule, and significant cervical lymph nodes are important in predicting malignancy. The accuracy rate in benign and atypia undetermined significance categories needs to improve in this study. Further research to help in decreasing false negative rates of FVPTC will help in increasing the accuracy of US-FNAC in the present study.
Neonatal Glycemic Status of Infants of Diabetic Mothers in a Tertiary Care Hospital

Background: Diabetes is a common medical complication during pregnancy that results in significant neonatal morbidities. In infants of diabetic mothers (IDMs), hypoglycemia is a common complication. Objective: To study the neonatal hypoglycemia in IDMs in a tertiary care hospital. Settings and Design: A cross-sectional study was done in postnatal ward in Bangladesh Institute of Research and Rehabilitation in Diabetic, Endocrine and Metabolic Disorders from January to December 2009. Subjects and Methods: The data of IDMs were collected from postnatal ward. All IDMs delivered during this period staying in postnatal ward were included in this study. The outcomes were compared between the hypoglycemic and normoglycemic IDMs and between gestational diabetes mellitus (GDM) and pre-GDM in hypoglycemic group using Chi-square test and Fisher's exact test. The data analysis was performed with Epi-enfo7 software. Statistical significance was set at P < 0.05. Results: A total of 363 IDMs were included in this study. Hypoglycemia developed in 38.3% IDMs and 43.2% mothers of hypoglycemic IDMs had GDM and 56.8% had pre-GDM. Duration of maternal diabetes (P = 0.04) and large for gestational age (P = 0.0001) were associated with hypoglycemia. Multigravidae (82.2% vs 68.3%, P = 0.03), prolonged duration of maternal diabetes (45.46 weeks vs 3.23 weeks, P = 0.00001), preterm babies (48.1% vs 28.3% P = 0.009), and control of diabetes by insulin (81% vs 46.7%, P = 0.001) were more in pre-GDM, and statistically significant. About 85% IDMs developed hypoglycemia within 6 h of birth (P-value 0.00001) and majority (68%) were at 2 h of age. Forty percent of hypoglycemic IDMs from postnatal ward were admitted in special care baby unit. Conclusion: Hypoglycemia observed in 38.3% IDMs and developed within 6 h of age and maximum were at 2 h. Early recognition and appropriate intervention are needed in IDMs.
Efficacy of Lesion Sterilization and Tissue Repair in Primary Tooth with Internal Resorption: A Case Series

Lesion sterilization and tissue repair (LSTR) treatment involves the use of a triple antibiotic mixture in a suitable vehicle, which is used to disinfect root canal systems. This report highlights three cases where LSTR therapy using triple antibiotic paste was attempted in primary molars exhibiting gross periradicular pathosis and internal resorption. Follow-up examinations revealed reduction of periradicular pathosis and reversal of internal resorption in all the three cases. This case series opens a perspective on the use of LSTR therapy as an alternative option to extraction in treating primary teeth with gross periradicular pathosis and internal resorption.