Miracle-dz/UniFAR-FTUs huggingface dataset:
Customer acceptance of playing online game on mobile phones

Online gaming keeps growing as a virtual entertainment industry with the improvement in IT applications and PC popularity. This study explored consumer acceptance after the implementation of online games through mobile phones, based on the 'Unified Theory of Acceptance and Use of Technology' (UTAUT) model, while considering the moderating effects of the online gaming experience and experience of web browsing on mobile phones. The research results indicate that performance expectancy, effort expectancy, social influence and facilitating conditions are all significant determinants of attitudes toward playing online games through mobiles and following the attitude positively influences behavioural intention. This research also reveals that the experience of playing online games and the experience of web browsing on mobile phones have a moderating effect on the acceptance of playing online games through mobile phones. Finally, management implications and future research are also presented in this research.
The effect of a healthy lifestyle program on the elderly's health in Arak.

BACKGROUND Increasing life-expectancy and decreasing birth rate have led to an increase in the elderly population worldwide so that the aging population is considered one of the biggest public health concerns in the present century which demands more attention to this vulnerable group. Therefore, the present study was done to determine the effect of a healthy lifestyle program on elderly's health in Arak. MATERIALS AND METHODS This quasi-experimental intervention study was carried out on 60 elderly citizens of Arak. The participants attended four instructional classes on nutrition, exercise, sleep hygiene, life skills, and personal hygiene over one month and they were followed for three months after the intervention. Data were collected through standard quality of life questionnaire (SF-36) and Katz standard ADLs in the elderly questionnaire before and three months after the completion of the study. RESULTS The average age of the participants was 67.61 ± 5.02 years. In terms of gender, the majority of the participants (60%) were male. In terms of quality of life before the instructional intervention, 13.3% of the participants were in low level, 30% in average level, 41.7% in good level, and 15% in the high level of quality of life. However, after the intervention, the majority of the participants were in good (38.3%) and high (45%) levels of quality of life which showed significant differences before and after the instructional intervention (P < 0.001). Moreover, there was a significant difference between Katz ADLs in the elderly before and after the intervention (P < 0.001). CONCLUSION The comparison between the quality of life and ADLs in the elderly before and after the intervention showed that continuing instruction for the elderly based on a regular healthy lifestyle program is effective and holding different instructional classes for this population, that is often ignored, seems necessary. The findings of this study can help design proper instructional guidelines on healthy lifestyle in the elderly.
Combined renin-angiotensin system gene polymorphisms and outcomes in coronary artery disease - a preliminary report.

BACKGROUND Common variants of the renin-angiotensin system (RAS) genes have been linked to a higher risk of coronary artery disease (CAD) and its complications. AIM To determine the prognostic significance of a combination of three common polymorphisms of RAS genes (angiotensin converting enzyme - ACE Ins/Del, angiotensin receptor type 1 - AGT1R A1166C and angiotensinogen - ATG M235T) in patients with CAD. METHODS The study included 216 patients (mean age 58 ± 9 years, 74% male) prospectively followed for a mean 41 ± 17 months. The end-points were all-cause mortality, myocardial infarction, stroke or the need for coronary revascularisation. RESULTS An end-point occurred in 41 (19%) patients. None of the polymorphisms analysed separately was associated with the end-point. Odds ratios were calculated for different combinations of analysed alleles to determine their relation to outcomes. Based on the cut-off points of odds ratios, the study group was divided into three subgroups: 55 patients without ATG 235T allele (T- subgroup); 100 patients with ATG 235T allele alone or ATG 235T allele combined with ACE Del allele or AGT1R 1166C allele (T+ or T+1 subgroup); and 61 patients with all three variants (T+2 subgroup). Multivariate analysis showed that the only independent predictor of the endpoint was an increasing number of variant genes (HR = 2.6, 95% CI 1.4-4.9, p = 0.002). CONCLUSIONS Co-existing angiotensinogen M235T AGT polymorphism and two other common polymorphisms of the RAS genes are related to adverse events in patients with CAD.
Structural phase transitions and stress accommodation in (La 0.67 Ca 0.33 MnO 3 ) 1-x :(MgO) x composite films

Composite (L 0 . 6 7 Ca 0 . 3 3 MnO 3 ) 1 - x :(MgO) x films were prepared by metalorganic aerosol deposition on a (100)MgO substrate for different concentrations of the (MgO) phase (0≤x≤0.8). At x0.3 a percolation threshold in conductivity is reached, at which an infinite insulating MgO cluster forms around the L 0 . 6 7 Ca 0 . 3 3 MnO 3 grains. This yields a drastic increase of the electrical resistance for films with x>0.3. The film structure is characterized by x-ray diffraction and transmission electron microscopy. The local structure of the La 0 . 6 7 Ca 0 . 3 3 MnO 3 within the film depends on the MgO concentration which grows epitaxially along the domain boundaries. A different structural phase transition from the orthorhombic Pnma structure to an unusual rhombohedral R3c structure at the percolation threshold x0.3 is found for La 0 . 6 7 Ca 0 . 3 3 MnO 3 . A three-dimensional stress accommodation in thick films through a phase transition is suggested.
Ethnic Variation in the Mitochondrial Targeting Sequence Polymorphism of MnSOD

In contrast to CuZn superoxide dismutase (SOD), only a very limited number of mutations have been described in MnSOD. One interesting example is a polymorphism (Ala-9Val) in the mitochondrial targeting sequence of this radical-scavenging enzyme. We have studied the Ala-9Val polymorphism in various ethnic groups by means of the oligonucleotide ligation assay. There were significant variations in this unique polymorphism between three different language groups: Baltic (Lithuanians), Finnic (Finns and Saamis) and Germanic (Swedes). The Ala frequency in an Asiatic population (Chinese) was significantly lower than in most European populations. This polymorphism may affect the mitochondrial targeting rate of MnSOD which may result in mitochondrial damage with implication in various late-onset neurological diseases.
Clostridium difficile Toxins TcdA and TcdB Cause Colonic Tissue Damage by Distinct Mechanisms

ABSTRACT As the major cause of antibiotic-associated diarrhea, Clostridium difficile is a serious problem in health care facilities worldwide. C. difficile produces two large toxins, TcdA and TcdB, which are the primary virulence factors in disease. The respective functions of these toxins have been difficult to discern, in part because the cytotoxicity profiles for these toxins differ with concentration and cell type. The goal of this study was to develop a cell culture model that would allow a side-by-side mechanistic comparison of the toxins. Conditionally immortalized, young adult mouse colonic (YAMC) epithelial cells demonstrate an exquisite sensitivity to both toxins with phenotypes that agree with observations in tissue explants. TcdA intoxication results in an apoptotic cell death that is dependent on the glucosyltransferase activity of the toxin. In contrast, TcdB has a bimodal mechanism; it induces apoptosis in a glucosyltransferase-dependent manner at lower concentrations and glucosyltransferase-independent necrotic death at higher concentrations. The direct comparison of the responses to TcdA and TcdB in cells and colonic explants provides the opportunity to unify a large body of observations made by many independent investigators.
Acute effects of short duration maximal endurance exercise on lipid, phospholipid and lipoprotein levels.

AIM The acute effects of maximal endurance exercise (15 min) on lipid and lipoprotein levels were examined, in order to determine whether the level of response produced could be affected by maximal exercise intensity (incremental stress test). METHODS Participants in this cross sectional study were male athletes (n=78) of national level: basketball (n=10), swimming (n=9), long distance (LD) running (n=23) and wrestling (n=35); also a group of non-athlete volunteers as controls (n=19). Athletes had trained an average of 3 h/day and 5 years. The ergometric test used for the determination of maximal oxygen uptake on a treadmill was based on a stepwise stress protocol. RESULTS Immediately after a maximal effort all groups (controls included) showed significant increases in total cholesterol (TC), triglycerides (TG), phospholipids (PL) and high-density cholesterol (HDL-C), from rest values. Low-density cholesterol (LDL-C) increased significantly in basketball, LD running and wrestling, while it did not change significantly in swimming and controls, after maximal effort. Hemoconcentration was of the order of +12.5%. CONCLUSIONS The level of these increases might be directly related to the intensity and duration of exercise performed. Acute endurance exercise (100% VO(2max)) may induce acute modification of the above lipid parameters potentiating the systematic chronic exercise effects already present.
The Effects of Deep Brain Stimulation on the Speech of Patients with Parkinson's Disease

THE EFFECTS OF DEEP BRAIN STIMULATION ON THE SPEECH OF PATIENTS WITH PARKINSON’S DISEASE Erin Suzanne Bjarnason Department of Communication Disorders Master of Science Abstract Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has received more attention in recent years as a treatment option for regulating the symptoms of Parkinson’s disease. Previous studies of DBS documented consistent improvements in motor function but more variability in speech outcomes. In the present study, six participants diagnosed with idiopathic Parkinson’s disease who reported worsened speech with stimulation were recorded performing speech acoustic tasks with the stimulators on, and again with the stimulators off. Improvements were noted for most participants in measurements of formant slopes, long term average spectrum (LTAS) of a sustained vowel, and spirantization with stimulation on. Stimulation negatively affected most participants’ vowel space area, verbal fluency, sequential motion rate, and LTAS while reading and describing a picture. Measures of stop gap duration, alternating motion rate,Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has received more attention in recent years as a treatment option for regulating the symptoms of Parkinson’s disease. Previous studies of DBS documented consistent improvements in motor function but more variability in speech outcomes. In the present study, six participants diagnosed with idiopathic Parkinson’s disease who reported worsened speech with stimulation were recorded performing speech acoustic tasks with the stimulators on, and again with the stimulators off. Improvements were noted for most participants in measurements of formant slopes, long term average spectrum (LTAS) of a sustained vowel, and spirantization with stimulation on. Stimulation negatively affected most participants’ vowel space area, verbal fluency, sequential motion rate, and LTAS while reading and describing a picture. Measures of stop gap duration, alternating motion rate, and voice onset time were within normal limits for most participants across both stimulation conditions.
Experimental Determination of Hydrodynamic Properties of Weathered Granite

Weathering processes transform hard fresh rock into regolith materials, composed of weathered bedrock and soils. The thickness of the weathered bedrock layer varies greatly, attaining several meters under certain climatic and lithologic conditions. The hydrology of catchments on bedrock is strongly controlled by the hydrologic functioning of these weathered bedrock layers, and the understanding and modeling of this functioning requires a knowledge of their hydraulic properties, such as their water retention curves. There are few references available on the water retention curve of weathered bedrock. To fill this gap, we measured the water retention characteristic of highly weathered Plomelin leucogranodiorite in replicate core samples. The study of weathered granite samples showed that their mean water retention curves differed significantly from those estimated for soil samples of the same grain size distribution using a pedotransfer function and for other granites with the same weathering index. Even if one can generate hypotheses to explain the observed differences, the three approaches we used to compare our results cannot replace the experimental approach to generate the water retention curve of a material such as weathered granite. In addition to enriching the body of work on water retention curves of weathered bedrocks, the results of this work suggest that there is a need for developing a database of retention properties of weathered bedrocks in parallel with the development of a model based on factors more appropriate than the weathering index.
The implementation of evidence-based medicine in general practice prescribing.

BACKGROUND Research on the implementation of evidence-based medicine has focused on how best to influence doctors through information and education strategies. In order to understand the barriers and facilitators to implementation, it may also be important to study the characteristics of those doctors and practices that successfully implement evidence-based changes. AIM To determine the relationship between practice and doctor characteristics and the implementation of recommended evidence-based changes in the area of prescribing. METHOD Visits were made to 39 practices in southern England. Audits of three key prescribing changes were carried out and amalgamated to produce an 'implementation score' for each practice. These scores were related to a wide range of practice and doctor variables obtained from a questionnaire survey of doctors and practice managers. RESULTS There was wide variation between the practices' implementation scores (mean 67%, range 45% to 88%). The only factors that had a significant relationship with implementation of these important prescribing changes were an innovative approach among the doctors (most practitioners were cautious of change), and fundholding status. Use of clinical protocols, disease registers, or computers was not associated with overall implementation score, nor was the doctor's age. Doctors complained of information overload. CONCLUSIONS The emphasis on the need for evidence in medicine, and better transmission of information, needs to be balanced by a recognition that most general practitioners are pragmatic, averse to innovation, and already feel overwhelmed with information. Important advances in therapy may be crowded out. More attention should be given to the facilitation of priority changes in practices.
Expression of Human RAD52 Confers Resistance to Ionizing Radiation in Mammalian Cells (*)

Processing of mutagenic DNA damages by the double strand breaks (DSB) in eukaryotes is most likely achieved by multiple pathways, including homologous recombination. Although RAD52 has been shown to be important for DSB repair in yeasts, its role in DSB repair in mammalian cells has not been demonstrated. This study reports for the first time that the overexpression of human RAD52 confers enhanced resistance to -rays and induces homologous intrachromosomal recombination in cultured monkey cells. Recombination frequency synergistically increased by the combination of overexpression of RAD52 and ionizing radiation. These observations suggest that homologous recombination mediated by RAD52 is involved in double-stranded break repair in mammalian cells.
Constitutive Activation of Two-Component Response Regulators: Characterization of VirG Activation in Agrobacterium tumefaciens

ABSTRACT Response regulators are the ultimate modulators in two-component signal transduction pathways. The N-terminal receiver domains generally accept phosphates from cognate histidine kinases to control output. VirG for example, the response regulator of the VirA/VirG two-component system in Agrobacterium tumefaciens, mediates the expression of virulence genes in response to plant host signals. Response regulators have a highly conserved structure and share a similar conformational activation upon phosphorylation, yet the sequence and structural features that determine or perturb the cooperative activation events are ill defined. Here we use VirG and the unique features of the Agrobacterium system to extend our understanding of the response regulator activation. Two previously isolated constitutive VirG mutants, VirGN54D and VirGI77V/D52E, provide the foundation for our studies. In vivo phosphorylation patterns establish that VirGN54D is able to accumulate phosphates from small-molecule phosphate donors, such as acetyl phosphate, while the VirGI77V/D52E allele carries conformational changes mimicking the active conformation. Further structural alterations on these two alleles begin to reveal the changes necessary for response regulator activation.
Brains, Bodies, Selves, and Science: Anthropologies of Identity and the Resurrection of the Body

930 Research for this article and related work in progress has been supported by a John Simon GuggenheimMemorial Fellowship and a grant from the Swiss National Science Foundation. Earlier versions were discussed at theMax Planck Institute for the History of Science (Berlin) and at the History of the Human SciencesWorkshop of theMorris Fishbein Center for the History of Science andMedicine (University of Chicago). I have profited greatly from comments, questions, and criticisms, especially from LorraineDaston, Jan Goldstein, Robert Proctor, Robert Richards, and Patrick Singy. Unless otherwise indicated, all translations are my own. 1. Dante Alighieri, Paradiso, vol. 3 of La divina commedia, ed. Natalino Sapegno (Florence, 1985), bk. 14, 11. 13–18, p. 185; hereafter abbreviated P. According to Thomas Aquinas, the resurrected body will shine more brightly than the sun, which burns the eye. Yet, because its light will emanate from the soul, it will only give pleasure to the blessed. See Thomas Aquinas, Summa theologica, trans. Fathers of the English Dominican Province, 5 vols. (Westminster, Mar., 1981), suppl. QQ. 85, art. 2, 5:2914. For Dante, virtually the entire experience of paradise is a confrontationwith unbearable light—“battaglia de’ debili cigli” (P, bk. 23, l. 78, p. 294). The poet even suffers temporary blindness when he tries to see through the light that emanates from Saint John’s soul in order to see the saint’s body, which according to legend had ascended directly to Paradise; see P, bk. 25, pp. 314–25. Brains, Bodies, Selves, and Science: Anthropologies of Identity and the Resurrection of the Body
The Impact of Perceived Emergency and Essentiality on Perceived Privacy Risk, Privacy Concern and Intention to Use in Mobile LBS Environment: An Example of China Mobile and Unicom

With the popularization of mobile devices and the rapidly development of LBS, users concern on privacy aroused by services depending on personal location information needed. To strengthen the current research in LBS, combine time management theory and rational choice theory, this paper aims to explore the effect of situational antecedent factors-perceived emergency and perceived essentiality on perceived privacy risk, privacy concern and intention to use. The experimental study was conducted and the findings indicate that perception of emergency and essentiality of a website characteristics have positive effect on intention to use not but on perceived privacy risk and privacy concern. Privacy concern has significant negative effect on intention to use. However, does not consistent with prior literature, the perceived privacy risk has significant direct effect on privacy concern not but on intention to use.
Cardiovascular Disease Risk and Adolescent Females 25 INTRODUCTION Predicting Cardiovascular Disease Risk

Brahler CJ, Stephens WR, Donahoe-Fillmore, B. Field Testing Adolescent Females for Cardiovascular Disease Risk. JEPonline 2009;;12(3):24-33. Over-fatness and poor cardiovascular (CV) fitness are well-documented risk factors for cardiovascular disease (CVD) in adults, but less is known about their association with disease risk in adolescents. This study aimed to determine the relationship between anthropometrics, fitness and CVD risk. Six anthropometric indicators of body fatness, seven measures of fitness, and seven metabolic and hemodynamic CVD risk factors were measured in a convenience sample of 28 female high school students (15-18 years of age). A tally was made of the number of factors for which each subject was outside the normal reference range (CVD risk). Correlation analyses were completed to determine the association between CVD risk and other study variables and regression analyses were completed to determine if any fitness or anthropometric variables were significant predictors of CVD risk. All anthropometric indicators of fatness were highly significantly correlated with CVD risk (P≤0.0001) while only three fitness variables reached a lower level of significance (P≤0.05). WC was the single best anthropometric or fitness predictor of the variance in CVD risk factors (r2=.742; p≤0.004). While SBP was the single best predictor of the variance in CVD risk when all study variables were considered (r2=.932; p≤0.0001). Anthropometric indicators of body fatness were more significantly associated with and predictive of CVD risk compared to fitness variables in a convenience sample of 28 female high school students. Non-invasive measures that are easily obtained in the school setting and may be useful in identifying adolescent females at high risk for developing CVD.
Studies on biodiversity of leaf litter fungi of Central Luzon State University and evaluation of their enzyme producing ability

Fungi are essential part of the ecosystem because they play an important role in the decomposition of organic materials such as plant residues. Fungi feed on dead organic matter and return the nutrients back into the soil. However, the occurrence of fungi growing on leaf litters which are responsible for decomposition are not yet fully studied and documented. Thus, in this study the different species of fungi present in leaf litters of three species of forest trees namely, rain tree (Samanea), orchid tree (Clitorea) and paper tree (Gmelina) were isolated and identified. These fungal species could be potentially used to hasten the decomposition of enormous leaf litters of forest trees. The isolated fungal species were screened for their ability to produce cellulase. A total of 30 species of phyllosphere fungi were isolated namely: Absidia sp. , Aspergillus flavus, A. fumigatus, A. japonicus, A. niger, A. niveus, A. tamarii, Colletotrichum gloeosporioides, Curvularia lunata, Eurotium repens, Fusarium acuminatum, F. semitectum, three unidentified species of Fusarium, Monascus ruber, Mucor piriformis, Neosartorya fischeri, Penicillium chrysogenum, P. citrinum, P. decumbens, P. hirsutum, P. implicatum, P. olsonii, P. oxalicum, P. purpurogenum, two unidentified species of Penicillium, Rhizopus microsporus and Trichoderma hamatum. Out of 30 species of phyllosphere fungi isolated, 22 can degrade cellulose as shown by the formation of clear zone around the colony of the organism. The five species of fungi that produced the largest clear zone were P. citrinum, P. olsonii, P. purpurogenum, A. niveus and P. chrysogenum.