Miracle-dz/UniFAR-FTUs huggingface dataset:
Endocrine-Related Cancer ( 2012 ) 19 541 – 556 miR-200 c is aberrantly expressed in leiomyomas in an ethnic-dependent manner and targets ZEBs , VEGFA , TIMP 2 , and FBLN 5

MicroRNA-200c (miR-200c) through repression of specific target genes has been associated with cellular transition, tumorigenesis, and tissue fibrosis. We explored the expression and functional aspects of miR-200c in genesis of leiomyomas (LYO), benign uterine tumors with fibrotic characteristic. Using LYO and matched myometrium (MYO; nZ76) from untreated and from patients exposed to hormonal therapies (GNRH agonist (GNRHa), Depo-Provera, and oral contraceptives), we found that miR-200c was expressed at significantly lower levels (P! 0.05) in LYO as compared with MYO. These levels were lower in LYO from African Americans as compared with Caucasians, patients experiencing abnormal uterine bleeding and those exposed to GNRHa therapy. Gain-of-function of miR-200c in isolated leiomyoma smooth muscle cells (LSMCs), myometrial smooth muscle cells (MSMCs), and leiomyosarcoma cell line (SKLM-S1) repressed ZEB1/ZEB2 mRNAs and proteins, with concurrent increase in E-cadherin (CDH1) and reduction in vimentin expression, phenotypic alteration, and inhibition of MSMC and LSMC proliferations. We further validated TIMP2, FBLN5, and VEGFA as direct targets of miR-200c through interaction with their respective 3 0 UTRs, and other genes as determined by microarray analysis. At tissue levels, LYO expressed lower levels of TIMP2 and FBLN5mRNAs but increased protein expressions, which to some extent altered due to hormonal exposure. Given the regulatory functions of ZEBs, VEGFA, FBLN5, and TIMP2 on cellular activities that promote cellular transition, angiogenesis, and matrix remodeling, we concluded that altered expression of miR-200c may have a significant impact on the outcome of LYO growth, maintenance of their mesenchymal and fibrotic characteristics, and possibly their associated symptoms. Endocrine-Related Cancer (2012) 19 541–556
How Finnish retail investors choose stock mutual funds - A qualitative study with an added emphasis on passive vs. active funds

An effective mutual fund market in which investors find and choose the funds which best suit their needs is beneficial from a societal perspective as it makes the markets more efficient. To bring the market closer to this goal, it is therefore importa nt to study how retail investors make mutual fund decisions. This thesis provides a qualitative study into how private Finnish stock mutual fund investors make their decisions, with an added emphasis on how they determine whether to choose actively or passively managed funds. The study adds to previous research on mutual fund decision making by bringing qualitative analysis to a subject that has mostly b een researched by using quantitative analysis techniques in the past. Also, there are no previous studies into h w Finnish retail investors choose between actively managed fu n s and passive funds. By conducting in depth semi-structured individual i nterviews for ten Finnish stock fund investors, the objective of this paper is to further our under standing of how retail investors, Finnish investors in particular, arrive at their investment choices. The interview data was analyzed to find patterns of behavior or ideas. The data was also compared to the results of past studies on mutual f und investor behavior and behavioral literature. The results of this study suggest that many Finnish retail investors do not perform any comparisons of fund companies, instead choosing the default opt ion, which is most often the investor’s bank. According to the data, the main factor in choosing specific funds within the chosen company’s options was the geographic location or industry of the stock holdings in the fund. The results differ significantly from those of past studi es, which have essentially all suggested that the p ast performance of funds is the most important factor i n choosing a stock fund. Further analysis suggests that the designs of previous questionnaire studies have been somewhat faulty as they left out some major decision factors, thus exaggerating the impor tance of some factors. The findings agree with past studies that significant portion of mutual fund investors are ignorant of many central issues regarding their investments. Finally , the research sugges ts that there is a large group of investors who would be potential index fund inve stors if they had a better knowledge of how index funds operate and if index funds were more ea sily vailable to them.
Effects induced by fungal endophytes in Catharanthus roseus tissues infected by phytoplasmas

Endophytes are microorganisms (fungi, bacteria, actinomycetes) that live inside host plants without causing disease symptoms or apparent injury. Aureobasidium pullulans and Epicoccum nigrum are two endophytic fungi of particular interest because they are reported as antibiotic producers and antagonists against different phytopatogenic microorganisms. In this work, the cytological effects caused by endophyte-inoculation in phytoplasma-infected Catharanthus roseus tissues were investigated. Ultrastructural observations performed on leaves of endophyte-inoculated cuttings evidenced phytoplasma structural modifications associated with the increasing of host defence response, such as formations of phloem protein plugs, callose occlusions and presence of vacuolar phenolic depositions in the lumen of sieve elements. These modifications lead to the enhancement of physical barriers preventing the phytoplasma movements in the host.
Excess Capacity and Capital Malleability in a Fishery with Myopic Expectations

ABSTRACT Understanding the process whereby fishing capital accumulates and excess capacity emerges, particularly in fisheries where incentives for race to fish and race to invest are present, and where capital is not perfectly malleable, remains an important topic. We develop a dynamic model, incorporating quasi-malleable capital, race to fish and invest behaviors and myopic expectations, in which the level of excess capacity is endogenously determined. We show the importance of capital malleability, and of other biological and economic conditions, in determining the existence and strength of persistent equilibrium excess capacity in the fishery. We also highlight a link between the state of the fishery at the time race behavior emerges and the resultant level of excess capacity. Our results have implications for both the management of excess capacity and the use of empirical measures of excess capacity as performance indicators in fisheries where race behaviors are present. JEL Codes: D24, Q22.
Tuning Multipath TCP for Interactive Applications on Smartphones

Multipath TCP enables smartphones to simultaneously use both WiFi and LTE to exchange data over a single connection. This provides bandwidth aggregation and more importantly reduces the handover delay when switching from one network to another. This is very important for delay sensitive applications such as the growing voice activated apps. On smartphones, user experience is always a compromise between network performance and energy consumption. However, the Multipath TCP implementation in the Linux kernel was mainly tuned for bandwidth aggregation and often wakes up the cellular interface by creating a path without sending data on it.In this paper, we propose, implement and evaluate MultiMob, a solution providing fast handover with low cellular usage for interactive applications. MultiMob relies on three principles. First, it delays the utilization of the LTE network. Second, it allows the mobile to inform the server of its currently preferred wireless network. Third, MultiMob extends the Multipath TCP handshake to enable immediate retransmissions to speedup handover. We implement MultiMob on Android 6 smartphones and evaluate its benefits by using both microbenchmarks and in the field measurements. Our results show that MultiMob provides similar latency as the standard Linux implementation while significantly lowering the cellular usage.
Tissue Interactions with Dermal Sheep Collagen Implants: A Transmission Electron Microscopical Evaluation

Tissue interactions with discs of dermal sheep collagen (DSC), subcutaneously implanted in rats, were evaluated using transmission electron microscopy. DSC cross-linked with hexamethylenediisocyanate (HDSC) had already been tested previously. In the present study, we compared tissue interactions of non-cross-linked DSC (NDSC) and glutaraldehyde-cross-linked DSC (GDSC) with those of HDSC. To gain more insight in the relation between basophil-like cells, foreign body multinucleate giant (FBM-G) cells derived from them, and aluminum/silicate (Al/Si)-crystals, we also implanted agarose-embedded Al/Si-crystals. GDSC induced early after implantation extensive lipid formation, cell degeneration and death, but NDSC did not have any cytotoxic effects. Basophil-like (FBM-G) cells specifically dealt with Al/Si-crystals, because they were attracted by the agarose-embedded Al/Si-crystals. These cells were also attracted by GDSC and NDSC, where Al/Si-crystals are present. Accumulation of Al/Si-crystals was especially prominent with GDSC. Degradation by phagocytosis was in part carried out by FBM-G cells, derived from macrophages or fibroblasts, and observed only with GDSC, which indicates that the presence of cross-links is a prerequisite for their formation.
A Mixed-Method Approach for Developing Market Segmentation Typologies in the Sports Industry

This study presents a mixed-method approach for segmenting a sports product-market using participation motivation data. Qualitative data are used to segment a national sports product-market—running footwear—using qualitative analysis software as well as multivariate statistical approaches. This study describes a systematic approach to developing a consumer segmentation typology using both demographic variables as well as self-expressed motivations for sport and fitness participation. The mixed-method approach reported here employs qualitative data to help validate subsequent quantitative cluster analysis, and draws upon cluster profiles to establish the structure for market segmentation. The findings from this study offer implications for marketing research and marketing communications in the sport industry. A Mixed-Method Approach for Developing Market Segmentation Typologies in the Sports Industry
A Non-Linear Manifold Alignment Approach to Robot Learning from Demonstrations

The number and variety of robots active in real-world environments are growing, as well as the skills they are expected to acquire, and to this end we present an approach for non-robotics-expert users to be able to easily teach a skill to a robot with potentially different, but unknown, kinematics from humans. This paper proposes a method that enables robots with unknown kinematics to learn skills from demonstrations. Our proposed method requires a motion trajectory obtained from human demonstrations via a vision-based system, which is then projected onto a corresponding human skeletal model. The kinematics mapping between the robot and the human model is learned by employing Local Procrustes Analysis, a manifold alignment technique which enables the transfer of the demonstrated trajectory from the human model to the robot. Finally, the transferred trajectory is encoded onto a parameterized motion skill, using Dynamic Movement Primitives, allowing it to be generalized to different situations. Experiments in simulation on the PR2 and Meka robots show that our method is able to correctly imitate various skills demonstrated by a human, and an analysis of the transfer of the acquired skills between the two robots is provided.
Secular Stagnation , Land Prices , and Collateral Constraints

Why was the recovery from the Great Recession slower than recoveries from other postwar recessions? This paper develops and quantifies a theory to account for this phenomenon. I propose a standard neoclassical model enriched with a land sector. Land can be used either as a consumption good for the household or as collateral for the firm to finance working capital. The model exhibits two locally stable steady states: one with high capital and high land price, and the other with low capital and low land price. At the good steady state, the high land price relaxes the firm’s working capital constraint. With enhanced employment capacity, the firm is induced to invest in capital, since capital and employment are complementary. This leads to higher capital accumulation and hence higher levels of household wealth. This, in turn, leads to strong demand for housing, which enhances the high land price. At the bad steady state, land price is depressed, which constrains the firm’s ability to finance working capital. This leads to low incentives to invest and, hence to lower levels of capital. This, in turn, implies lower levels of household wealth, which sustains the low land price. The multiplicity of steady states allows for asymmetric responses to small and large shocks. Large adverse shocks have a much more persistent impact, as they trigger transitions from one steady state to the other. A calibrated version of the model displays significantly delayed recovery upon large adverse shocks and is consistent with various features of the Great Recession and its aftermath. ∗Address: 4-101 Hanson Hall, 1925 Fourth Street South, Minneapolis, MN 55414, USA, e-mail: caixx162@umn.edu. The author is grateful to VV Chari and Jonathan Heathcote for invaluable guidance. The author also thanks Manuel Amador, Anmol Bhandari, Christopher Phelan, Si Guo, Zhen Huo, Kyle Herkenhoff, Larry Jones, Wenzel Lee, Keler Marku, Zoe Xie, Pei-cheng Yu, and seminar participants at the Public Workshop at the University of Minnesota and Mathematical Economics Workshop at the University of Minnesota for helpful comments.
The metabolic utilization of iron and copper in the young swine organism.

The aim of this study was to evaluate the influence of different iron and copper levels from the compound feed over the bioproductive performances of young swine, also the evolution of the contained iron and copper in blood, liver, fat and muscles, in the conditions in which during 2 weeks iron and copper marked with radioactive isotope Fe and Cu have been used. The researches have been made on the number of 75 pigs from the LS-345 Peris Synthetical Line, being divided in 3 batches uniformly by body weight (11.5 kg). The swine nutrition from all the 3 batches has been realized with the same compound feed, the differences being in the different proportion of the two microelements (iron and copper) from vitamino-mineral premix (batch no.1 received 95 mg iron/kg compound feed and 6 mg copper/kg, batch no. 2-85 mg iron/kg compound feed and 5 mg copper/kg, batch no. 3-75 mg iron/kg compound feed and 4 mg copper/kg). The best bioproductive performances (average daily gain, average daily consumption, specific consumption) have been obtained by the young swine in which’s compound feed level has been of 85 mg iron/kg and 5 mg copper/kg. After giving the radioactive isotopes the highest values of iron have been observed in liver and muscles, moreover in case of copper, they can be found in liver. For the young swine copper is a growing biostimulating factor, influencing positively the iron metabolism.
Bayesian Approach to Urinary ESBL-Producing Escherichia coli

This is a retrospective study about the prevalence of ESBL-producing Escherichia coli (EEC) in urinary specimens from patients from the Comunitat Valenciana from January 2007 to December 2008. Data were retrieved from RedMIVA, and Bayesian generalized linear mixed models were considered to study the prevalence of EEC with regard to demographical and microbiological factors. The total number of infections considered was 164,502, the amount of urinary isolates was 70,827 belonging to 49,304 different patients, and 5,161 (7.3%) of the urinary isolates were EEC. Three out of four E. coli were isolated in women (76.8%), men showed higher rates of EEC (9.7% in men vs. 6.5% in women). EEC patients were, in average, 10.8 years older, and hospitalization was more frequent (9.9% vs. 6.9%). Resistance to non-β-lactams antimicrobials was higher in EEC. The rates of ciprofloxacin and co-trimoxazol resistance in EEC were 75.5% and 52.0%, respectively, whereas it ranged between 1.4-12.4% for the rest of antimicrobials. Prior EEC infection and hospitalization were the most relevant risk factors and increased the expected EEC probability approximately 400% and 50% respectively. Other infections played an important and positive role too, Enterobacteriaceae, P. aeruginosa and other bacteria being the most relevant elements. Female gender was a protective factor and reduced the risk by approximately 25% while age was an additive risk factor. Finally, an open-access web-based software was constructed to compute the probability that an E. coli in a urinary infection be an EEC from a specific combination of risk factors. This pharmacovigilance tool should prove useful to monitor and control antimicrobial resistance spread.
Moderate and formal cohomology associated with constructible sheaves

On a complex manifold X, we construct the functors · w ⊗OX and Thom( · ,OX) of formal and moderate cohomology from the category of R-constructible sheaves to that of DX -modules. It allows us to treat functorially and in a unified manner C ∞ functions, distributions, formal completion and local algebraic cohomology. The behavior of these functors under the usual operations on D-modules is systematically studied, and adjunction formulas for correspondences of complex manifolds are obtained. This theory provides a natural tool to treat integral transformations with growth conditions such as Radon, Poisson and Laplace transforms. Resume Sur une variete complexe X, nous construisons les foncteurs · w ⊗OX et Thom( · ,OX) de cohomologie formelle et moderee de la categorie des faisceaux R-constructibles a valeurs dans celle desDX -modules. Cela permet de traiter fonctoriellement et de maniere unifiee les fonctions C , les distributions, la completion formelle et la cohomologie locale algebrique. On etudie systematiquement le comportement de ces foncteurs pour les operations usuelles sur les D-modules, et on obtient des formules d’adjonction pour les correspondances de varietes complexes. * Research Institute for Mathematical Sciences, Kyoto University, Kyoto 606, Japan ** Institut de Mathematiques, Universite Paris VI, Case 247, 4 Place Jussieu 75252 Paris, France e-mail schapira@mathp6.jussieu. fr AMS Classification 58G99, 46F20, 18E30, 32S60
Comparison of three analytical procedures to estimate the acid detergent fiber concentration in feeds of widespread use in Argentina.

El objetivo de este trabajo fue comparar la determinacion del contenido de fibra insoluble en detergente acido (FDA) en alimentos muy utilizados en Argentina, mediante tres procedimientos analiticos diferentes.Los procedimientos comparados fueron dos involucrando la tecnica de las bolsas filtrantes ANKOM (FBT) consistentes en el tratamiento directo de las muestras con solucion detergente acido (D-ADF), y en el tratamiento secuencial primero con detergente neutro seguido de detergente acido todo sobre la misma muestra (S-ADF). El tercer procedimiento fue la tecnica tradicional de Van Soest utilizando crisoles de capa filtrante (VS-FDA). Los materiales analizados, elegidos debido a su gran difusion para la alimentacion del ganado fueron: Harina de soja, granos de maiz y semillas de girasol, pasto fresco de agropiro alargado (Thinopyrum ponticum), alfalfa (Medicago sativa), pasto guinea (Panicum maximum), cebada (Hordeum vulgare), pasto lloron (Eragrostis curvula Nees) y raigrass annual (Lolium multiflorum), y ensilajes de maiz y de pasturas perennes consociadas. Por cada procedimiento y alimento se practicaron cuatro corridas analiticas. Los analisis estadisticos mostraron que los resultados de S-ADF difirieron tanto de VS-FDA como de D-FDA. Se encontraron altas correlaciones lineales (R2 > 0.99) entre VS-ADF y D-ADF con S-ADF. Sin embargo, las diferencias encontradas entre los procedimientos para algunos de los alimentos indican que la metodologia utilizada para evaluar el contenido ADF debera ser claramente identificada al reportar resultados
Nutrient recovery from olive by-products through vermicomposting with Eisenia andrei

In this study, Eisenia andrei potential for detoxification of the olive by-products was evaluated. A standard mixture containing 600 g of olive pomace (OP), 300 g of horse manure and 100 g of wheat straw was imbibed by various olive mill wastewater (OMW) ratios (0%, 10%, 25% and 50%) to prepare four mixtures (M1, M2, M3 and M4 respectively), then inoculated with adult earthworms. The biological parameters related to earthworm’s biomass gain and reproduction rate were better in the mixture M1 which used as control mixture (10.7 mg worm -1 day -1 and 0.17 cocoons worm -1 day -1 respectively) followed by M2 and M3. When OMW ratio exceeded 50% of OMW (M4), mortality of earthworm occurred after 7 days of incubation. The reduction of phenol concentration was higher in mixture M1 (91%) compared to other mixtures (M2: 72%, M3: 54%). The C/N ratio decreased in all mixtures to reach values between 17 and 22 at the end of vermicomposting process. The phytotoxicity test revealed that the overall germination index was greater than 80% in M1, M2 and M3, which showed that vermicompost produced can be used as organic amendment for biological and sustainable
SIGNIFICANCE OF THE DMF!T+t" INDEX FOR THE CHILDREN WITH PREMATURELY EXTRACTED TEETH

Premature extraction of temporary teeth is a consequence of different factors such as socio-economic status of the population, level of caries activity, oral hygiene, presence of fluoride in water, philosophy of the dentist. The aim of this article is to compare the DMF (T+t) between children with premature extraction and those without premature extraction. Subject of monitoring of the clinical research were 140 children between 6 and 9 years old. The clinical group consisted of 90 children with prematurely extracted teeth, divided into three groups. The control group consisted of 50 children with intact denture. The dental status was examined and registered according to the WHO by the DMF (T+t). There was a statistically significant difference in the distribution of caries DMF(T+t) between the control groups (2.34±019) and clinical groups (between 5.17±0.33 and 6.40±0.41). The children with premature extraction of temporary teeth had higher caries activity compared to the control group (children without early loss of teeth). The children with prematurely extracted temporary teeth and severe orthodontic deformation had the highest prevalence of DMF(T+t). These results demonstrate the connection between DMF(T+t), malocclusions and the need for prophylaxis.
Do we bank on regulation or reputation? A meta-analysis and meta-regression of organizational trust in the financial services sector

Purpose – Trust in financial institutions has been eroded through the collapse of mortgage-related securities, with confidence further denuded through well publicized cases of rogue traders and rate fixing cases, such as with the Lehman brothers, the Libor rate-fixing scandals, and the hypo real estate breakdown. In response to these events, governments have introduced a range of distinct policy initiatives designed to restore trust in this sector. Thus, the question arises: are these regulations and control mechanisms sufficient in isolation, or are there other elements that this sector needs to pay attention to in efforts to build and sustain customers’ trust? The paper aims to discuss these issues. Design/methodology/approach – There is a compelling agenda for both financial organizations and academics to understand better organizational trust in this context especially the role and impact of regulatory mechanisms in its development and repair. The paper therefore examines the special facets of the fin.