Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevalence, social and health correlates of insomnia among persons 15 years and older in Indonesia

ABSTRACT The study aims to investigate the prevalence and social and health correlates of insomnia symptoms in a national sample of older Indonesians who formed part of the ‘Indonesia Family Life Survey (IFLS-5)’ in 2014–15. A community-based cross-sectional study with a probability sample of 31,432 persons 15 years or older was conducted in Indonesia. Measures included information on insomnia, socio-demographic, health, physical activity, anthropometric and blood pressure. Results indicate that 55.7% of participants had no insomnia, 33.3% had sub-threshold insomnia and 11.0% had clinically significant insomnia symptoms. In adjusted logistic regression decreasing age, lower education, lower economic status, urban residence, lower religiosity, having experienced childhood hunger, and one or more disasters increased the odds of having insomnia. Poorer self-rated health status, increasing number of chronic conditions, functional disability, poorer cognitive functioning, and health care utilization in the past four weeks were associated with insomnia. Further, the prevalence of having insomnia was higher in those who were current tobacco users, were highly physically active, consumed infrequently fruit and vegetables, and frequently ate fast food and drank soft drinks. A significant proportion of Indonesians have insomnia symptoms and several risk factors were identified that can help in guiding interventions.
Impact of infertility and infertility treatments on quality of life and levels of anxiety and depression in women undergoing in vitro fertilization

Abstract This study aims to evaluate levels of anxiety and depression in women, correlated with infertility per se and with infertility treatments, highlighting predictors of higher levels of distress. Two validated standardized questionnaires, the Hospital Anxiety and Depression Scale (HADS) and the Fertility Quality of Life (FertiQoL), were administered to 89 women both before their first cycle of infertility treatment and again at the end of the ovarian stimulation for in vitro fertilization (IVF). Women's levels of anxiety were significantly higher before the treatment than during the treatment itself. Stratifying the women in three groups based on principal cause of infertility (male infertility, female infertility, or both male and female), we found significantly higher levels of anxiety and general distress in patients under treatment for female infertility. Higher anxiety levels in our sample before the treatment are probably an effect of not knowing what they are expected to do to solve their problem. Moreover, when the cause of infertility is exclusively female, women experience higher levels of anxiety and general distress both before and during the treatment, probably correlated to a sense of guilt. These data help the treating physician to better counsel patients and to provide a more focused psychological support.
An introduction to scientific research methods in geography & environmental studies

Introduction: A Scientific Approach to Geography and Environmental Studies Fundamental Research Concepts Scientific Communication Data Collection in Geography and Environmental Studies: Overview Physical Measurements Behavioural Oservations and Archives Explicit Reports: Surveys, Interviews and Tests Experimental and Non-Experimental Research Designs Sampling Statistical Data Analysis Data Display: Tables, Graphs, Maps, Visualizations Reliability and Validity Information Technologies in Research Ethics in Scientific Research
Effect of Recrystallization Annealing on Corrosion Behavior of Ta-4%W Alloy

The effect of recrystallization annealing on corrosion behavior of Ta-4%W alloy was studied. It is found that the deformed sample contains high dense dislocations and dislocation boundaries. During annealing, these dislocations and dislocation boundaries are replaced by recrystallizing grains until the alloy is fully recrystallized. Both the anodic dissolution and the cathodic activity is much more blocked. The corrosion potential gradual shift towards negative values and corrosion current density decrease, while polarization resistance increases after annealing, indicating enhanced corrosion resistance of the alloy. Such an enhancement is caused by the increase of low-Σ coincide site lattice boundaries and decrease of dislocations and dislocation boundaries.
Risk factors for vasoplegia after cardiac surgery: a meta-analysis.

OBJECTIVES Postoperative vasoplegia (PV) is a common haemodynamic disorder after cardiac surgery and is associated with high operative mortality. Preventive and potent therapeutic measures are critical to improve the outcome. Identification of risk factors for PV may increase awareness and prompt therapeutic action. Our objective was to pool the available evidence on the risk factors for PV in cardiac surgery and to perform a meta-analysis. METHODS PubMed, Embase, Ovid and Google Scholar databases were searched for studies published between 1965 and 2017. Three investigators independently screened the studies and extracted the data. Pooled estimates were obtained by a random effects model. Preoperative and operative patient data were gathered to determine their association with PV. RESULTS The search yielded 109 potential studies for inclusion. Of these, 10 articles were analysed and their data extracted. The total number of patients included was 30 035 patients (1524 with vasoplegia and 28 511 without vasoplegia). The only preoperative variable that was significantly associated with PV was renal failure [odds ratio (OR) 1.47; 95% confidence interval (CI) 1.17-1.86]. Patients with isolated coronary artery bypass grafting had a lower risk for PV (OR 0.36; 95% CI 0.22-0.59), whereas previous cardiac surgery (OR 2.03; 95% CI 1.27-3.26) and combined procedures increased its incidence (OR 2.12; 95% CI 1.82-2.47). PV increased with higher use of red blood cells (OR 2.12; 95% CI 1.82-2.47), longer aortic cross-clamp (mean difference 8.15 min; 95% CI 8.79-27.50 min) and cardiopulmonary bypass (mean difference 25.72 min; 95% CI 12.75-38.69 min) duration. CONCLUSIONS Patients with renal failure, higher use of red blood cell, longer and combined cardiac surgery procedures are at a higher risk for PV. Measures to promptly identify and treat PV in these patients should be considered.
Effect of Lateral Ligament Augmentation Using Suture-Tape on Functional Ankle Instability

Background: Although lateral ligament augmentation using suture-tape has been effective for restoration of mechanical ankle stability, few data are available regarding changes of peroneal strength, proprioception, and postural control. The aim of this study was to determine effects of suture-tape augmentation on functional ankle instability (FAI). Methods: Twenty-four patients who underwent suture-tape augmentation were eligible and were followed more than 2 years postoperatively. Functional outcomes were evaluated with the Cumberland Ankle Instability Tool (CAIT), Foot and Ankle Ability Measure (FAAM). Changes of peroneal strength, proprioception and postural control were analyzed with an isokinetic dynamometer and a modified Romberg test. Results: CAIT and FAAM (average of daily and sports activity scores) significantly improved to average 27.2 points and 86.7 points, respectively, at final follow-up. Peak torque for eversion in 60 degrees/s angular velocity significantly improved to 10.6 Nm at final follow-up. Deficit ratio of peak torque for eversion significantly improved from mean 39.5% to 20.9%, and significant side-to-side difference was revealed (P < .001). There were no significant differences in joint position sense. A significant improvement in balance retention time was revealed at final follow-up, and the relative deficit ratio compared to the unaffected side was 30.9%. Conclusions: Patient-reported functional outcomes significantly improved after lateral ligament augmentation using suture-tape. Although this procedure demonstrated significant effects on FAI based on improvement of isokinetic peroneal strength and postural control, recovery rates compared to the unaffected side were not significant at the intermediate-term follow-up. In addition, there was no positive effect on proprioception of the ankle. Level of Evidence: Level IV, prospective case series.
Outcomes and prognostic variables associated with central division hepatic lobectomies: 61 dogs

OBJECTIVE To determine the outcome and prognostic variables associated with long-term survival and complications in dogs undergoing hepatic lobectomy of the central division. STUDY DESIGN Multi-institutional retrospective case series. ANIMALS Sixty-one client-owned dogs with central division masses. METHODS Medical records of dogs undergoing hepatic lobectomy of the central division from January 1, 2000 to January 1, 2015 were reviewed for signalment, clinical signs, preoperative staging, preoperative cytology or biopsy results, date of procedure, location of mass, surgical technique, whether cholecystectomy or cholecystopexy was performed, complications, histopathologic diagnosis and margin evaluation, date of local recurrence or detection of metastatic disease, and survival. RESULTS Hilar resection was associated with increased intraoperative and postoperative complications. Intraoperative complications occurred in 29 dogs, with 20 dogs experiencing intraoperative hemorrhage. Nineteen dogs required transfusions. Immediate postoperative complications occurred in 20 dogs. Perioperative mortality rate was 11%, and 2-week mortality rate was 14.7%. The median survival time for dogs with hepatocellular carcinoma (HCC) was not reached. The 1- and 3-year censored survival rates for dogs with HCC was 82.1% and 82.1%, respectively. Margin status did not impact survival time. CONCLUSION Hepatic lobectomy of the central division was associated with hemorrhage in approximately 33% of dogs, but there was a relatively low perioperative mortality rate. Hepatic lobectomy for HCC resulted in long-term survival, regardless of margin status. CLINICAL SIGNIFICANCE Surgeons should anticipate the requirement for blood products in dogs that may require hepatic lobectomy of the central division. Long-term survival can be expected after surgical treatment of HCC, regardless of margin status.
Spatial and temporal habitat partitioning by calliphorid blowflies

Calliphorid blowflies perform an essential ecosystem service in the consumption, recycling and dispersion of carrion nutrients and are considered amongst the most important functional groups in an ecosystem. Some species are of economic importance as facultative agents of livestock myiasis. The interspecific ecological differences that facilitate coexistence within the blowfly community are not fully understood. The aim of this work was to quantify differences in habitat use by calliphorid species. Thirty traps were distributed among three habitats at two sites in southwest England for collections made during March–August 2016. A total of 17 246 specimens were caught, of which 2427 were Lucilia sericata, 51 Lucilia richardsi, 6580 Lucilia caesar, 307 Lucilia ampullacea, 4881 Calliphora vicina and 2959 Calliphora vomitoria (all: Diptera: Calliphoridae). Lucilia sericata was the dominant species in open habitats, whereas L. caesar was the most abundant species in shaded habitats. Calliphora specimens were more abundant in the cooler months. These findings suggest that Calliphora and Lucilia species show strong temporal segregation mediated by temperature, and that species of the genus Lucilia show differences in the use of habitats that are likely to be driven by differences in humidity tolerance and light intensity. These factors in combination result in effective niche partitioning.
Editorial Comment.

subject inclusion criteria were not based on the most recent evidence-based ISSM definition of PE of an IELT of less than 1 minute. This clinical trial was performed before the guideline was published and when there was no consensus on the cutoff to define PE. PE has typically been defined as ejaculation occurring within 1 to 2 minutes of intercourse or inability of the man to control ejaculation timing. This may limit the generalizability of our results. 2) Lifelong PE and acquired PE are distinct clinical diseases considered to have different pathophysiological mechanisms. However, we were not able to separate these 2 classifications. Therefore, it is necessary to clarify differences in the efficacy of on demand treatment of clomipramine 15 mg between lifelong PE and acquired PE.
Encoding of kinetic and kinematic movement parameters in the sensorimotor cortex: A Brain‐Computer Interface perspective

For severely paralyzed people, Brain‐Computer Interfaces (BCIs) can potentially replace lost motor output and provide a brain‐based control signal for augmentative and alternative communication devices or neuroprosthetics. Many BCIs focus on neuronal signals acquired from the hand area of the sensorimotor cortex, employing changes in the patterns of neuronal firing or spectral power associated with one or more types of hand movement. Hand and finger movement can be described by two groups of movement features, namely kinematics (spatial and motion aspects) and kinetics (muscles and forces). Despite extensive primate and human research, it is not fully understood how these features are represented in the SMC and how they lead to the appropriate movement. Yet, the available information may provide insight into which features are most suitable for BCI control. To that purpose, the current paper provides an in‐depth review on the movement features encoded in the SMC. Even though there is no consensus on how exactly the SMC generates movement, we conclude that some parameters are well represented in the SMC and can be accurately used for BCI control with discrete as well as continuous feedback. However, the vast evidence also suggests that movement should be interpreted as a combination of multiple parameters rather than isolated ones, pleading for further exploration of sensorimotor control models for accurate BCI control.
Human rotavirus A detection: Comparison of enzymatic immunoassay and rapid chromatographic test with two quantitative RT-PCR assays.

OBJECTIVE The aim of this study was to compare results of two commercially available kits used for routine detection of Rotavirus A in human stool samples with results of commercial quantitative reverse-transcription PCR (RT-qPCR) test and in-house RT-qPCR. MATERIAL AND METHODS In total, 749 stool samples were screen-ed with the use of four different methods. The samples were collected from four diagnostic laboratories from March 2016 to June 2017. Diagnose of gastrointestinal disorders was stated in one third of tested patients, the rest of samples was collected from patients with other primary diagnose. The samples were tested with the enzymatic immunoassay (EIA) (RIDASCREEN® Rotavirus) and with rapid diagnostic immunochromatographic test (RDT) (IMMUNOQUICK® No-Rot-Adeno). As a reference method a commercial RT-qPCR test was used (Primerdesign Genesig® Kit) and it was compared with in-house RT-qPCR test prepared in our laboratory. The samples which in the reference RT-qPCR gave positive signal of reaction in cycle 28 or higher (Ct 28) were assessed as negatives in order to include only samples with some clinical relevance into sensitivity determination. RESULTS Diagnostic sensitivity was assessed as 84.2% for EIA and 82.5% for RDT. The specificity of those tests was calculated as 97.8% for EIA and 96.4% for RDT. The performance of both diagnostic tests describing their positive predictive value was determined to be 87.3% for EIA and 80.3% for RDT. Negative predictive value was calculated to be 97.2% for EIA and 96.8% for RDT. Proportion of RVA-positive samples determined with the reference RT-qPCR test with our own cut-off level was 15.2% (n=114). Comparisons of the in-house and reference RT-qPCR tests showed very good agreement of results. The sensitivity of the in-house test was 100% and its specificity 99.7%. CONCLUSIONS RT-qPCR is more sensitive for surveillance of rotavirus gastroenteritis than routinely used EIA or RDT methods. The specificity of both evaluated tests was very high. However, EIA was in all performance parameters assessed better than RDT.
Longitudinally Mapping Childhood Socioeconomic Status Associations with Cortical and Subcortical Morphology

Childhood socioeconomic status (SES) impacts cognitive development and mental health, but its association with human structural brain development is not yet well characterized. Here, we analyzed 1243 longitudinally acquired structural MRI scans from 623 youth (299 female/324 male) to investigate the relation between SES and cortical and subcortical morphology between ages 5 and 25 years. We found positive associations between SES and total volumes of the brain, cortical sheet, and four separate subcortical structures. These associations were stable between ages 5 and 25. Surface-based shape analysis revealed that higher SES is associated with areal expansion of lateral prefrontal, anterior cingulate, lateral temporal, and superior parietal cortices and ventrolateral thalamic, and medial amygdalo-hippocampal subregions. Meta-analyses of functional imaging data indicate that cortical correlates of SES are centered on brain systems subserving sensorimotor functions, language, memory, and emotional processing. We further show that anatomical variation within a subset of these cortical regions partially mediates the positive association between SES and IQ. Finally, we identify neuroanatomical correlates of SES that exist above and beyond accompanying variation in IQ. Although SES is clearly a complex construct that likely relates to development through diverse, nondeterministic processes, our findings elucidate potential neuroanatomical mediators of the association between SES and cognitive outcomes. SIGNIFICANCE STATEMENT Childhood socioeconomic status (SES) has been associated with developmental disparities in mental health, cognitive ability, and academic achievement, but efforts to understand underlying SES–brain relationships are ongoing. Here, we leverage a unique developmental neuroimaging dataset to longitudinally map the associations between SES and regional brain anatomy at high spatiotemporal resolution. We find widespread associations between SES and global cortical and subcortical volumes and surface area and localize these correlations to a distributed set of cortical, thalamic, and amygdalo-hippocampal subregions. Anatomical variation within a subset of these regions partially mediates the positive relationship between SES and IQ. Our findings help to localize cortical and subcortical systems that represent candidate biological substrates for the known relationships between SES and cognition.
Relationship of Cardiorespiratory Endurance to Fundamental Movement Skill Proficiency among Adolescents

This study investigated a possible relationship between cardiorespiratory endurance and fundamental movement skill proficiency among adolescents. Locomotor (run and jump) and object-control (catch, throw, kick, and strike) skills and cardiorespiratory endurance, indirectly measured using the Multistage Fitness Test (MFT) or PACER, were assessed in 2,026 boys and girls in Grade 8 (mean age = 13.3 years) and Grade 10 (mean age = 15.3 years), who were part of a randomly selected sample who agreed to participate in the New South Wales Schools Fitness and Physical Activity Survey, 1997. Boys had higher levels of cardiorespiratory endurance and were more competent than girls on 5 out of 6 skills. Grade 10 students were better on all skills and were aerobically fitter than Grade 8 students. All six skills and a skills index were related to the number of laps completed on the MFT. The six skills explained 20% and 26% of the variance in the number of laps completed on the MFT for Grade 8 and Grade 10 girls, respec.
Targeted Delivery of Sildenafil for Inhibiting Pulmonary Vascular Remodeling

Pulmonary arterial hypertension is a fatal lung disease caused by the progressive remodeling of small pulmonary arteries (PAs). Sildenafil can prevent the remodeling of PAs, but conventional sildenafil formulations have shown limited treatment efficacy for their poor accumulation in PAs. Here, glucuronic acid (GlcA)-modified liposomes (GlcA-Lips) were developed to improve the delivery of sildenafil to aberrant over-proliferative PA smooth muscle cells via targeting the GLUT-1 (glucose transport-1), and, therefore, inhibiting the remodeling of PAs in a monocrotaline-induced PA hypertension model. GlcA-Lips encapsulating sildenafil (GlcA-sildenafil-Lips) had a size of 90 nm and a pH-sensitive drug release pattern. Immunostaining assay indicated the overexpression of GLUT-1 in PA smooth muscle cells. Cellular uptake studies showed a 1-fold increase of GlcA-Lips uptake by PA smooth muscle cells and pharmacokinetics and biodistribution experiments indicated longer blood circulation time of GlcA-Lips and increased ability to target PAs by 1-fold after 8 hours administration. Two-week treatment indicated GlcA-sildenafil-Lips significantly inhibited the remodeling of PAs, with a 32% reduction in the PA pressure, a 41% decrease in the medial thickening, and a 44% reduction of the right ventricle cardiomyocyte hypertrophy, and improved survival rate. Immunohistochemical analysis showed enhanced expression of caspase-3, after administration of GlcA-sildenafil-Lips, and reduced expression of P-ERK1/2 (phosphorylated ERK1/2) and HK-2 (hexokinase-2), and increased level of eNOS (endothelial nitric oxide synthase) and cyclic GMP (cGMP). In conclusion, targeted delivery of sildenafil to PA smooth muscle cells with GlcA-Lips could effectively inhibit the remodeling of PAs in the monocrotaline-induced PA hypertension.
The Multidimensional Scale of Perceived Social Support (MSPSS): Reliability and Validity of Russian Version

ABSTRACT Objective: To assess factorial and construct validity along with reliability of the Russian version of the Multidimensional Scale of Perceived Social Support (MSPSS) in cardiac patients. Methods: The study included 1018 patients with coronary artery disease. All patients were offered the opportunity to complete a questionnaire to detect psychosocial risk and protective factors, including the MSPSS. Results: Internal consistency of the Russian version of the MSPSS was high: Cronbach’s alpha coefficient in the group of patients with stable angina was . 91 vs. . 90 in the group with acute coronary syndrome. The three-factor structure of the MSPSS was proved with exploratory and confirmatory factor analyses. As expected, the Russian version of the MSPSS was negatively correlated with measures of anxiety and depression, and positively correlated with curiosity. Conclusions: The Russian version of MSPSS corresponds closely with the English version in reliability, consistency, and internal structure. Test–retest reliability was satisfactorally high and construct validity was supported with the results of the correlation analysis. Clinical Implications: Our study confirms that MSPSS questionnaire is a high valid tool to estimate social support and it can be successfully applied to define social support in patients with cardiac pathology.