Miracle-dz/UniFAR-FTUs huggingface dataset:
The social dimension of multi-racial advertising : its impact on consumers' attitude

Since the end of the apartheid regime, the number of advertisements casting actors from different racial backgrounds simultaneously has significantly increased. Comments about this development are multi-faceted. While some observers praise this technique as the ideal social mirror of the "new" South Africa, others criticize it as a pervasive commercial tactic. Consistent with this debate, it is important for brands to understand consumers' perceptions of multi-racial advertising. Indeed, these perceptions are also assumed to influence consumers' attitude towards the advertised brand. Based on the attribution theory, this study investigates whether South African companies, by integrating a multi-racial feature in an advertisement, create the perception amongst consumers that their advertisement is socially responsible and, in so doing, increase their brand equity. The empirical results of this study support that consumers' attitude towards a brand is significantly influenced by the extent to which they attribute a social responsibility to its advertisements. Nevertheless, it is also found that using multi-racial advertising is a necessary but not sufficient condition to generate this social attribution.
Spatial and temporal patterns of oligodendrocyte differentiation in rat cerebrum and cerebellum

Oligodendrocytes are largely generated postnatally during mammalian CNS development. We have used a variety of antibodies to label immature neuroectodermal cells and developing oligodendrocytes in several areas of the rat CNS. Antibodies included those to GD3 ganglioside, a characteristic glycolipid of immature cells; carbonic anhydrase (CA), contained primarily in oligodendrocytes; and galactocerebroside and myelin basic protein, myelin components. Several aspects of oligodendrocyte development were examined: changes in shapes of immature cells with respect to time and to location within the brain, the sequential acquisition of the various markers, and possible sites of origin and pathways of precursor cell migration. Our observations suggest that oligodendrocytes in the forebrain and cerebellum arise from cells of the subventricular zone (SVZ) adjacent to the ventricles and migrate into and through nearby white and gray matter. During maturation, there are distinct patterns of morphological changes that correlate with time, locations of the cells in the brain, and acquisition of specific markers.
Precision and accuracy of a new device (CNAPTM) for continuous non-invasive arterial pressure monitoring: assessment during general anaesthesia.

BACKGROUND Continuous non-invasive arterial pressure measured with CNAP (CNAP) has been shown to be superior to intermittent oscillometric measurements during procedural sedation and spinal anaesthesia. We assessed the performance of CNAP during general anaesthesia by analysis of agreement with invasive measurements of arterial pressure (AP). METHODS Eighty-eight patients undergoing elective abdominal surgery, cardio-, or neurosurgery were included in the study. Systolic, diastolic, and mean AP measured by an intra-arterial catheter in the radial artery (IAP) were compared with those obtained by CNAP from the same arm. Data were analysed to determine the precision (i.e. measurement error) and accuracy (i.e. systematic error) of beat-to-beat CNAP values with respect to IAP. Also, we compared the frequency of fast changes in AP (FCAP) and hypotension (IOH) by both methods. RESULTS CNAP precision of 4.5, 3.1, and 3.2 mm Hg (systolic, diastolic, and mean AP, respectively) was not significantly different from IAP precision, and CNAP accuracy was +6.7, -5.6, and -1.6 mm Hg. The frequency of AP pairs having a difference within the calculated limits of agreement was 81%, 64%, and 76% for systolic, diastolic, and mean AP, respectively. The calculated limits of agreement were +/-17.6, +/-11.4, and +/-12.0 mm, Hg, respectively. CNAP and IAP detected simultaneously to 82.1% FCAP and to 84.6% IOH. CONCLUSIONS CNAP provides real-time estimates of arterial pressure comparable with those generated by an invasive intra-arterial catheter system during general anaesthesia.
Confidence Intervals for Conditional Tail Risk Measures in ARMA–GARCH Models

ABSTRACT ARMA–GARCH models are widely used to model the conditional mean and conditional variance dynamics of returns on risky assets. Empirical results suggest heavy-tailed innovations with positive extreme value index for these models. Hence, one may use extreme value theory to estimate extreme quantiles of residuals. Using weak convergence of the weighted sequential tail empirical process of the residuals, we derive the limiting distribution of extreme conditional Value-at-Risk (CVaR) and conditional expected shortfall (CES) estimates for a wide range of extreme value index estimators. To construct confidence intervals, we propose to use self-normalization. This leads to improved coverage vis-à-vis the normal approximation, while delivering slightly wider confidence intervals. A data-driven choice of the number of upper order statistics in the estimation is suggested and shown to work well in simulations. An application to stock index returns documents the improvements of CVaR and CES forecasts.
Amino acid uptake and energy coupling dependent on photosynthesis in Anacystis nidulans

The photoautotrophic cyanobacterium Anacystis nidulans was used to investigate the membrane transport of branched-chain, neutral amino acids and its dependence on photosynthetic reactions. The uptake of alpha-amino [1-14C]isobutyric acid and L-[1-14C]leucine followed Michaelis, Menten kinetics and resulted in an energy-dependent accumulation. As in bacteria, different uptake systems for neutral amino acids were present: two DAG (D-alanine, aminoisobutyric acid, and glycine) systems responsible for uptake of alpha-amino [1-14C]isobutyric acid, and one LIV (leucine, isoleucine, and valine) system, responsible for uptake of leucine. The low-affinity DAG system seemed to be dependent on the presence of Na+ ions. Uptake was enhanced by white light and by monochromatic light of 630 nm. In far red light (717 nm) with and without nitrogen flushing, considerable uptake dependent on light intensity and inhibition by dibromothymoquinone and by high concentrations of KCN were observed. Therefore, the energy generated by photosystem I reactions only could perform this membrane transport. The proton translocator carbonylcyanide m-chlorophenylhydrazone and N,N-dicyclohexylcarbodiimide as an ATPase inhibitor reduced amino acid uptake to a high degree. A pH dependence of aminoisobutyric acid and leucine uptake was obvious, with a maximum at pH 6 to 7 and some at a pH as high as 9.5. At higher pH, increasing concentrations of Na+ K+ and also of triphenylmethylphosphonium ions inhibited the transport of aminoisobutyric acid. These findings are consistent with the assumption that ATP from photosynthetic reactions drives a membrane-bound proton-translocating ATPase producing a proton motive force, consisting at higher pH chiefly in a delta psi amount, which promotes a secondary active H+ or Na+/amino acid symport carrier.
Not Just by Walking Distance: Residential Segregation and Children’s Network Integration in the City of Bremen

How does residential segregation affect 12-year-old children’s networks of home visit with their friends? According to social exchange theory, children visiting the household of their friends’ family increases integration. Focus theory suggests that the effect of residential segregation on these visits is mediated by “intermediary” network ties of friendship and spending leisure time. Accordingly, spatial segregation influences networks of home visits by a stepwise process of network creation and intensification, and not just by walking distance. Empirical evidence is based on a school survey in the German city of Bremen and combines exponential random graph (p*) models (ERGM) for networks with path analysis. Results of direct and indirect effects are in line with focus theory: 57% of the effect of spatial proximity on ties in the visits-at-home network is mediated by ties in networks of spending leisure time together, which, in turn, is mediated by the influence of spatial proximity on ties in friendship networks.
The Collateral Rule: An Empirical Analysis of the CDS Market

We study the empirical determinants of collateral requirements in the cleared credit default swap (CDS) market: how margins depend on portfolio risks and market conditions, and what the implications are for theoretical models of collateral equilibrium. We construct a novel data set containing CDS portfolios and margins posted by all participants to the main CDS clearinghouse, ICE Clear Credit, covering 60% of the U.S. market. We provide direct empirical evidence that margins are much more conservatively set than what a Value-at-Risk (VaR) rule would imply, and are unequally implemented across participants. We show that more extreme tail risk measures have a higher explanatory power for observed collateral requirements than VaR, consistent with endogenous collateral theories such as Fostel and Geanakoplos (2015) where extreme events dominate in determining collateral. The dependence of collateral requirements on extreme tail risks induces potential nonlinearities in margin spirals, dampening small shocks and amplifying large ones. We also confirm empirically the main channel through which collateral-feedback effects operate in many theoretical models of equilibriums with financial frictions, such as Brunnermeier and Pedersen (2009), highlighting the prominent role of aggregate volatility and funding costs.
Hospitality entrepreneurs managing quality of life and business growth

The hospitality industry is dominated by small- and medium-sized enterprises (SMEs). They are often led by entrepreneurs who face the challenge of simultaneously managing business decisions and their own wellbeing. The competitiveness of tourism destinations often depends on these entrepreneurs and therefore understanding their motivations and work patterns is critical. Research on individual wellbeing increasingly builds on the concept of quality of life (QoL). Hospitality and tourism literature so far predominantly focused on investigating QoL for tourists and residents, rather than for entrepreneurs’ QoL, even though being key stakeholders in the hospitality industry. Therefore, this study explores the factors influencing hospitality entrepreneurs’ quality of life (“HE-QoL”) and how these relate to business growth. Results of a 380 hospitality entrepreneurs’ survey identify six distinct factors of HE-QoL. Two groups of HE-QoL are identified with significant differences in fitness level activity, entrepreneurial competencies and business growth. Findings lead to recommendations to reduce stress to improve HE-QoL, and to develop entrepreneurial competencies, which help to cope with entrepreneurial challenges. Tourism destinations and politics can support hospitality entrepreneurs in these actions by creating conditions that foster social exchange in regional communities and trust in political and economic stability.
Immune Response in Infants to the Heptavalent Pneumococcal Conjugate Vaccine against Vaccine-Related Serotypes 6A and 19A

ABSTRACT The currently available 7-valent pneumococcal conjugate vaccine (PCV7) elicits good immune response to and is effective against vaccine serotypes. However, its effectiveness against vaccine-related serotypes is variable. Serum samples were obtained 1 month after the last vaccination from 31 infants immunized with PCV7 at 2, 4, and 6 months of age. The sera were used to determine immunoglobulin G antibody levels to eight serotypes (seven vaccine serotypes and serotype 19A) with enzyme-linked immunosorbent assay (ELISA) and opsonic capacity against 11 serotypes (seven vaccine serotypes, serotypes 19A and 6A, and nonvaccine serotypes 5 and 7F) using a multiplexed opsonization assay. ELISA results showed antibody concentrations varied between 1.84 and 10.49 μg/ml, and all subjects had antibody concentrations of ≥0.35 μg/ml for all serotypes, including serotype 19A. In contrast, the opsonic index was detectable (i.e., opsonic index ≥ 8) in all children for the seven vaccine serotypes, 81% for serotype 6A, and merely 19% for serotype 19A. PCV7 shows good immunogenicity for vaccine serotypes in infants after a primary series. PCV7 does not elicit opsonic antibodies to serotype 19A. ELISA may thus be an inadequate surrogate assay for evaluating the response for cross-reactive serotypes in infants.
Family history of type 2 diabetes: A population-based screening tool for prevention?

Purpose: To evaluate the use of self-reported family medical history as a potential screening tool to identify people at-risk for diabetes.Methods: The HealthStyles 2004 mail survey comprises 4345 US adults who completed a questionnaire to ascertain personal and family history of diabetes, perceived risk of diabetes, and practice of risk-reducing behaviors. Using number and type of affected relatives, respondents were ranked into three familial risk levels. Adjusted odds ratios (AORs) were obtained to evaluate associations between familial risk and prevalent diabetes, perceived risk of disease, and risk-reducing behaviors. Validity of family history as a screening tool was examined by calculating sensitivity, specificity, and positive and negative predictive values.Results: Compared to those of average risk, people with moderate and high familial risk of diabetes were more likely to report a diagnosis of diabetes (AOR: 3.6, 95% CI: 2.8, 4.7; OR: 7.6, 95% CI: 5.9, 9.8, respectively), a higher perceived risk of diabetes (AOR: 4.6, 95% CI: 3.7, 5.7; OR: 8.5, 95% CI: 6.6, 17.7, respectively), and making lifestyle changes to prevent diabetes (AOR: 2.2, 95% CI: 1.8, 2.7; OR: 4.5, 95% CI: 3.6, 5.6, respectively). A positive familial risk of diabetes identified 73% of all respondents with diabetes and correctly predicted prevalent diabetes in 21.5% of respondents.Conclusion: Family history of diabetes is not only a risk factor for the disease but is also positively associated with risk awareness and risk-reducing behaviors. It may provide a useful screening tool for detection and prevention of diabetes.
cDNA cloning of heat shock proteins and their expression in the two phases of the migratory locust

The high population density of insects is often a stress factor. Insects synthesize heat shock proteins (Hsps) in response to the impacts of stress through molecular chaperone activity. Locust solitary and gregarious phases occur at low and high population density, respectively. In this study, we compare the expression profiles of the Hsp genes in the two phases of the migratory locust in an attempt to examine the role of Hsps in adaptation to high density populations. The full length cDNAs of Hsp20.5, 20.6, 20.7, 40, 70 and Hsp90 of the migratory locust were cloned and sequenced. The expressional differentiation of the six Hsps in mRNA levels between solitary and gregarious locusts was observed. Results from real‐time PCR indicate that the six Hsps are expressed throughout all developmental stages except in the early stage embryo. The expression levels of the six Hsps were significantly upregulated in gregarious locusts. The expressional variations among certain organs, such as the head, thorax and leg of fifth instar nymphs in gregarious locusts were also higher than those in solitary ones. These observations suggest that population density may be an important factor in determining Hsp expression in the locust.
Facts, noise and wishful thinking: muscle protein turnover in aging and human disuse atrophy

Surprisingly little is known about the mechanisms of muscle atrophy with aging and disuse in human beings, in contrast to rodents, from which much has been extrapolated to explain the human condition. However, this extrapolation is likely unwarranted because the time course, extent of wasting, muscle fiber involvement and alterations of muscle protein turnover are all quite different in rodent and human muscle. Furthermore, there is little evidence that static indices of protein turnover represent dynamic changes and may be misleading. With disuse there are reductions in the rate of muscle protein synthesis (MPS) large enough to explain the atrophic loss of muscle protein without a concomitant increase in proteolysis. In aging, there is no evidence that there are marked alterations in basal muscle protein turnover in healthy individuals but instead the ability to maintain muscle after feeding is compromised. This anabolic resistance is evident with physical inactivity, which exacerbates the inability to maintain muscle mass with aging. The main conclusion of this review is that in uncomplicated, non‐inflammatory disuse atrophy, the facilitative change causing loss of muscle mass is a depression of MPS, exacerbated by anabolic resistance during feeding, with possible adaptive depressions, rather than increases, of muscle proteolysis.
Motor Learning Enhances Use-Dependent Plasticity

Motor behaviors are shaped not only by current sensory signals but also by the history of recent experiences. For instance, repeated movements toward a particular target bias the subsequent movements toward that target direction. This process, called use-dependent plasticity (UDP), is considered a basic and goal-independent way of forming motor memories. Most studies consider movement history as the critical component that leads to UDP (Classen et al., 1998; Verstynen and Sabes, 2011). However, the effects of learning (i.e., improved performance) on UDP during movement repetition have not been investigated. Here, we used transcranial magnetic stimulation in two experiments to assess plasticity changes occurring in the primary motor cortex after individuals repeated reinforced and nonreinforced actions. The first experiment assessed whether learning a skill task modulates UDP. We found that a group that successfully learned the skill task showed greater UDP than a group that did not accumulate learning, but made comparable repeated actions. The second experiment aimed to understand the role of reinforcement learning in UDP while controlling for reward magnitude and action kinematics. We found that providing subjects with a binary reward without visual feedback of the cursor led to increased UDP effects. Subjects in the group that received comparable reward not associated with their actions maintained the previously induced UDP. Our findings illustrate how reinforcing consistent actions strengthens use-dependent memories and provide insight into operant mechanisms that modulate plastic changes in the motor cortex. SIGNIFICANCE STATEMENT Performing consistent motor actions induces use-dependent plastic changes in the motor cortex. This plasticity reflects one of the basic forms of human motor learning. Past studies assumed that this form of learning is exclusively affected by repetition of actions. However, here we showed that success-based reinforcement signals could affect the human use-dependent plasticity (UDP) process. Our results indicate that learning augments and interacts with UDP. This effect is important to the understanding of the interplay between the different forms of motor learning and suggests that reinforcement is not only important to learning new behaviors, but can shape our subsequent behavior via its interaction with UDP.
Metabolic Testing in the Office

The three most commonly used metabolic tests are the Resting Metabolic Rate, Anaerobic Threshold Testing, and V˙O2max. For several decades, these metabolic tests have been confined to the setting of university-based physiology laboratories and cardiopulmonary environments, i.e., metabolic carts in the intensive care units. The information gathered is used as a research and clinical tool in evaluating metabolic activity in a variety of physiological states from a body at rest, to exercise (aerobic and anaerobic), in certain medical states like illness, fed/starvation, and medicinal or supplementation affective states. Over the last decade, as technology has improved, so have the metabolic testing carts. They have become widely available for mainstream use by a variety of health care professionals. The purpose of this article is to review these three tests and how they may be useful in a medical practice.
Decomposing Multi‐Level Ethnic Segregation in Auckland, New Zealand, 2001–2013: Segregation Intensity for Multiple Groups at Multiple Scales

There has been a growing appreciation that the processes generating urban residential segregation operate at multiple scales, stimulating innovations into the measurement of their outcomes. This paper applies a multi‐level modelling approach to that issue to the situation in Auckland, where multiple migration streams from both Pacific Island and Asian origins have created a complex multi‐ethnic city. We identify two distinct trends. For the larger ethnic groups segregation remained static despite rapid growth over a recent twelve‐year period. For the smaller groups growth has been combined with considerable change; they initially clustered in a few localities and areas within them but then experienced considerable reduction in the intensity of that segregation. By spatially decomposing the segregation levels, this paper extends our appreciation of its underpinning processes when they apply to migration streams that differ in their nature from those on which traditional residential location‐decision theory has been based.
Does democracy promote capital account liberalization?

Abstract Conventional wisdom maintains that democracy promotes market-oriented economic reforms. This paper argues that democracy’s effect on economic liberalization hinges on international-systemic factors. To develop this argument, we focus on one important reform issue: capital account liberalization. We hypothesize that the level of financial openness abroad moderates the relationship between democracy and financial policy at home. An open global financial system increases societal support for capital account liberalization and incentivizes democratic leaders to liberalize the capital account. Analyses of country-level panel data demonstrate that democracy is only positively associated with capital account openness when proximate countries maintain open capital markets. Firm-level survey data and an illustrative case study of Argentina provide support for the mechanisms by showing that policy choices abroad influence domestic support for capital account liberalization. Our findings suggest that integrating domestic- and international-level variables in a single framework improves our understanding of the political economy of reform.
A Multicenter Study of the Ambu® Laryngeal Mask in Nonparalyzed, Anesthetized Patients

We designed this multicenter trial to evaluate the performance and safety of the Ambu® laryngeal mask, a new disposable supraglottic airway device, in patients scheduled for elective surgery. One-hundred-eighteen nonparalyzed, anesthetized patients (ASA physical status I–II, age, 18–65 yr, body mass index, 18–30 kg/m−2) receiving total IV anesthesia were included in this study. After device insertion, fiberoptic position and oropharyngeal leak pressure were determined at an intracuff pressure of 60 cm H2O. Ease of ventilation was determined by controlling ventilation at 6 mL/kg tidal volume. Any complications were noted and recorded. Device placement was successful in all patients on the first or second attempt (92.4% or 7.6%, respectively) with an insertion time (removal of face mask until first tidal volume) of 44.9 ± 37.91 s. Adequate ventilation was achieved in all patients and the vocal cords could be visualized by fiberoptic endoscopy in 91.5% of patients. Oropharyngeal leak pressures were 24.1 ± 5.44 cm H2O. Blood was detected on the device in 8.5% of patients. Complications and patient complaints were minor and quickly resolved. The Ambu laryngeal mask is easy and quick to insert and provides a safe and efficient seal during positive pressure ventilation in nonparalyzed patients scheduled for elective surgery.