Miracle-dz/UniFAR-FTUs huggingface dataset:
Health promotion : foundations for practice

Introduction Section 1 the theory of Health Promotion concepts of Health Influences on health Measuring health Defining health promotion Models and approaches to health promotion Ethical Issues in health promotion the politics of health promotion. Section 2: Strategies and Methods Partnerships for health-working together Public health work working with communities and community development Helping people to change using the mass media in health promotion. Sections 3: Settings for Health Promotion: Health promotion in the workplace Helath promotion in schools Health promotion in primary healthcare and hospitals. Section 4: Working for Health Promotion: Assessing health needs Planning health promotion interventions Evaluation in health promotion.
New RIC Bounds via ` q-minimization with 0 < q ≤ 1 in Compressed Sensing

The restricted isometry constants (RICs) play an important role in exact recovery theory of sparse signals via `q(0 < q ≤ 1) relaxations in compressed sensing. Recently, Cai and Zhang [6] have achieved a sharp bound δtk < √ 1− 1/t for t ≥ 4 3 to guarantee the exact recovery of k sparse signals through the `1 minimization. This paper aims to establish new RICs bounds via `q(0 < q ≤ 1) relaxation. Based on a key inequality on `q norm, we show that (i) the exact recovery can be succeeded via `1/2 and `1 minimizations if δtk < √ 1− 1/t for any t > 1, (ii)several sufficient conditions can be derived, such as for any q ∈ (0, 1 2 ), δ2k < 0.5547 when k ≥ 2, for any q ∈ ( 12 , 1), δ2k < 0.6782 when k ≥ 1, (iii) the bound on δk is given as well for any 0 < q ≤ 1, especially for q = 1 2 , 1, we obtain δk < 13 when k(≥ 2) is even or δk < 0.3203 when k(≥ 3) is odd.
Physical activity to prevent obesity in young children: cluster randomised controlled trial

Objective To assess whether a physical activity intervention reduces body mass index in young children. Design Cluster randomised controlled single blinded trial over 12 months. Setting Thirty six nurseries in Glasgow, Scotland. Participants 545 children in their preschool year, mean age 4.2 years (SD 0.2) at baseline. Intervention Enhanced physical activity programme in nursery (three 30 minute sessions a week over 24 weeks) plus home based health education aimed at increasing physical activity through play and reducing sedentary behaviour. Main outcome measure Body mass index, expressed as a standard deviation score relative to UK 1990 reference data. Secondary measures were objectively measured physical activity and sedentary behaviour; fundamental movement skills; and evaluation of the process. Results Group allocation had no significant effect on the primary outcome measure at six and 12 months or on measures of physical activity and sedentary behaviour by accelerometry. Children in the intervention group had significantly higher performance in movement skills tests than control children at six month follow-up (P=0.0027; 95% confidence interval 0.3 to 1.3) after adjustment for sex and baseline performance. Conclusions Physical activity can significantly improve motor skills but did not reduce body mass index in young children in this trial. Trial registration Current Controlled Trials ISRCTN36363490.
Benchmarking a new three-dimensional ultrasound system for prostate image guided radiation therapy

Image guided radiation therapy (IGRT) is a new type of radiotherapy used to deliver lethal doses of radiation to mobile tumors, while preventing surrounding healthy structures from receiving high doses of radiation. It relies on image guidance to track the tumor and ensure its prescribed position in the radiation beam. The main goal of this work was to determine if a new three-dimensional ultrasound (3D US) image guidance device, called the Restitu System, could safely replace (or be used interchangeably with) an existing method involving x-ray images of implanted fiducial markers (FMs) for prostate IGRT. Using comparison statistics called 95 % limits of agreement (LOA), it was found that the new 3D US system did not produce measurements that agreed sufficiently closely to those made using the FM technique, and therefore, could not safely replace FMs for prostate IGRT. Ultrasound image quality and user variability were determined to have a significant impact on the agreement between the two methods. It was further shown that using the Restitu System offered no significant clinical advantages over a conventional patient re-positioning technique.
Compressed Sensing with Probability-based Prior Information

This paper deals with the design of a sensing matrix along with a sparse recovery algorithm by utilizing the probability-based prior information for compressed sensing system. With the knowledge of the probability for each atom of the dictionary being used, a diagonal weighted matrix is obtained and then the sensing matrix is designed by minimizing a weighted function such that the Gram of the equivalent dictionary is as close to the Gram of dictionary as possible. An analytical solution for the corresponding sensing matrix is derived which leads to low computational complexity. We also exploit this prior information through the sparse recovery stage and propose a probability-driven orthogonal matching pursuit algorithm that improves the accuracy of the recovery. Simulations for synthetic data and application scenarios of surveillance video are carried out to compare the performance of the proposed methods with some existing algorithms. The results reveal that the proposed CS system outperforms existing CS systems.
Consistency Regularization for Generative Adversarial Networks

Generative Adversarial Networks (GANs) are known to be difficult to train, despite considerable research effort. Several regularization techniques for stabilizing training have been proposed, but they introduce non-trivial computational overheads and interact poorly with existing techniques like spectral normalization. In this work, we propose a simple, effective training stabilizer based on the notion of consistency regularization---a popular technique in the semi-supervised learning literature. In particular, we augment data passing into the GAN discriminator and penalize the sensitivity of the discriminator to these augmentations. We conduct a series of experiments to demonstrate that consistency regularization works effectively with spectral normalization and various GAN architectures, loss functions and optimizer settings. Our method achieves the best FID scores for unconditional image generation compared to other regularization methods on CIFAR-10 and CelebA. Moreover, Our consistency regularized GAN (CR-GAN) improves state-of-the-art FID scores for conditional generation from 14.73 to 11.48 on CIFAR-10 and from 8.73 to 6.66 on ImageNet-2012.
Short-distance constraints on hadronic light-by-light scattering in the anomalous magnetic moment of the muon

A key ingredient in the evaluation of hadronic light-by-light (HLBL) scattering in the anomalous magnetic moment of the muon ðg − 2Þμ concerns short-distance constraints that follow from QCD by means of the operator product expansion. Here we concentrate on the most important such constraint, in the longitudinal amplitudes, and show that it can be implemented efficiently in terms of a Regge sum over excited-pseudoscalar states, constrained by phenomenological input on masses, two-photon couplings, as well as short-distance constraints on HLBL scattering and the pseudoscalar transition form factors. Ourestimate of the effect of the longitudinal short-distance constraints on the HLBL contribution is ΔaLSDC 1⁄4 13ð6Þ × 10−11. This is significantly smaller than previous estimates, which mostly relied on μ an ad-hoc modification of the pseudoscalar poles and led to up to a 40% increase with respect to the nominal pseudoscalar-pole contributions, when evaluated with modern input for the relevant transition form factors. We also comment on the status of the transversal short-distance constraints and, by matching to perturbative QCD, argue that the corresponding correction will be significantly smaller than its longitudinal counterpart.
Use of X-ray CT-defined regions of interest for the determination of SPECT recovery coefficients

For accurate activity per unit volume measurements in SPECT, recovery coefficients are usually applied based on the size and shape of objects being imaged to properly account for the resolution limitations of the gamma camera. Because of noise and limited spatial resolution, determination of object sizes and boundaries can be difficult using the SPECT images alone. The authors therefore have developed a technique which determines activity concentrations for SPECT using regions of interest (ROI's) obtained from coregistered X-ray CT images. In this study, experimental phantoms containing cylindrical and spherical objects were imaged on a combined X-ray CT/SPECT system and reconstructed data volumes were registered using the known geometry of the system. ROI's were defined on the registered CT images and used to help quantify activity concentration in localized regions and to measure object volumes. The authors have derived the recovery curves for these objects and scan technique. They have also tested a technique that demonstrates activity quantitation without the need for object and size dependent recovery coefficients in the case of low background.
The Mass Relations between Supermassive Black Holes and Their Host Galaxies at 1 < z < 2 with HST-WFC3

Correlations between the mass of a supermassive black hole (SMBH) and the properties of its host galaxy (e.g., total stellar mass M*, luminosity Lhost) suggest an evolutionary connection. A powerful test of a coevolution scenario is to measure the relations  BH –Lhost and  BH –M* at high redshift and compare with local estimates. For this purpose, we acquired Hubble Space Telescope (HST) imaging with WFC3 of 32 X-ray-selected broad-line (type 1) active galactic nuclei at 1.2 < z < 1.7 in deep survey fields. By applying state-of-the-art tools to decompose the HST images including available ACS data, we measured the host galaxy luminosity and stellar mass along with other properties through the two-dimensional model fitting. The black hole mass (  BH ) was determined using the broad Hα line, detected in the near-infrared with the Subaru Fiber Multi-Object Spectrograph, which potentially minimizes systematic effects using other indicators. We find that the observed ratio of  BH to total M* is 2.7× larger at z ∼ 1.5 than in the local universe, while the scatter is equivalent between the two epochs. A nonevolving mass ratio is consistent with the data at the 2σ–3σ confidence level when accounting for selection effects (estimated using two independent and complementary methods) and their uncertainties. The relationship between  BH and host galaxy total luminosity paints a similar picture. Therefore, our results cannot distinguish whether SMBHs and their total host stellar mass and luminosity proceed in lockstep or whether the growth of the former somewhat overshoots the latter, given the uncertainties. Based on a statistical estimate of the bulge-to-total mass fraction, the ratio  BH /M*,bulge is offset from the local value by a factor of ∼7, which is significant even accounting for selection effects. Taken together, these observations are consistent with a scenario in which stellar mass is subsequently transferred from an angular momentum–supported component of the galaxy to a pressure-supported one through secular processes or minor mergers at a faster rate than mass accretion onto the SMBH.
Elastic plate osteosynthesis of femoral shaft fractures in young dogs

Summary The outcome of femoral fracture repair in young growing dogs using the principle of elastic osteosynthesis was evaluated in a retrospective clinical trial. Unilateral fractures in twenty four dogs, in the first phase of their growth, were repaired with a Veterinary Cuttable Plate (VCP). The plates were applied according to the principles of bridge plating. They were fixed with two screws at each end, positioned as far as possible from the fracture site, leaving a flexible segment between them. The plates contained between seven and 20 holes. The dogs soon used their treated limb and callus was often complete by four weeks. The plates were removed in 18 cases. A very good outcome was recorded in 21 dogs, one dog ran away after two months at which time the owner reported an excellent gait, one dog died of an unrelated problem and one other dog exhibited slight lameness which was attributed to stifle problems. In all of the cases the growing diaphysis was apparently undisturbed. It was concluded that adequate fixation of the fractures was achieved and conditions for rapid bone union was created. The successful use of Veterinary Cuttable Plates, VCP, for the treatment of fractured femurs in immature dogs, is reported
Wild potato species threatened by extinction in the Department of La Paz, Bolivia

The Department of La Paz has the largest number of wild potato species (Solanum Section Petota Solanaceae) in Bolivia, some of which are rare and threatened by extinction. Solanum achacachense, S. candolleanum, S. circaeifolium, S. okadae, S. soestii and S. virgultorum were all searched for in their type localities and new areas. Isolated specimens of S. achacachense were found in its type localities, while S. candolleanum was found in low density populations. Solanum circaeifolium was also found as isolated specimens or in low density populations in its type localities, but also in new areas. Solanum soestii and S. okadae were found in small, isolated populations. No specimen of S. virgultorum was found at all. The majority of the wild species searched for suffered the attack of pathogenic fungi. Interviews with local farmers revealed the main factors negatively affecting these species to be loss of habitat through urbanization and the use of the land for agriculture and forestry. Some 37.8% of those interviewed knew the local uses of the wild potatoes studied. Additional key words: genetic erosion, locality type, rare species, Solanum sp. , threatened species.
THE SERVICE-PROFIT CHAIN

Over the years, the relationship banking model shows a stable and strong model. This corresponds to the theory of the service-profit chain. The relationships among the service-profit chain model have been examined many times. This study examines the link between employee engagement and customer loyalty and the link between customer loyalty and the financial performance. The first relationship is investigated in a theoretical way and a descriptive part about the engagement drivers at Rabobank Alkmaar e.o. Several other studies find that there is a clear relationship between employee engagement and customer loyalty. Besides, it is shown that wage; job characteristics and job development are main drivers for employee engagement. The second link is investigated in an empirical way. From 122 respondents the customer contribution and the Net Promoter Score are measured. A clear link is found between the Net Promoter Score and the customer contribution in the segment of adult enterprises.
Clinical Efficacy and Side Effects of Nabumeton Compared to Meloxicam in Osteoarthritis Pain

Background : Most patients who use non steroid anti-inflammatory drug (NSAID) in long-term or high-dose will experience NSAID gastropathy that appears as dyspepsia complaints. The aim of this study is to assess the efficacy of nabumeton and incidence of dyspepsia as side effect of treatment using nabumeton compared to meloxicam in patients with pain due to osteoarthritis. Methods : Sixty patients with pain due to osteoarthritis at internal medicine clinic in Koja Hospital were included in this study and were given meloxicam or nabumeton within February 29th to March 25 in double-blind manner. Primary disease pain degree and heartburn pain degree were evaluated three days after administration of the drug and a week was added if necessary. The statistical analysis used were student t-test to compare changes in pain scores between the 2 groups, and Chi-square test to assess differences in the number of dyspepsia in both groups. Results: Pain scale reduction in meloxicam group was 0.57 ± 0.67 points, which is less than 1.27 ± 0.74 points in nabumeton group. In addition, the average recurrence of heartburn in the meloxicam was 18 out of 30 (60%) patients in total, while the average recurrence of heartburn in nabumeton was 2 out of 30 (60%) patients. Conclusion : The use of nabumeton pain medication is better in terms of efficacy and side effects of heartburn compared to meloxicam. Keywords : osteoarthritis, joint pain, meloxicam, nabumeton
Epigenetic regulation of Dlg1, via Kaiso, alters mitotic spindle polarity and promotes intestinal tumourigenesis. Authors:

Both alterations to the epigenome and loss of polarity have been linked to cancer initiation, progression and metastasis. It has previously been demonstrated that loss of the epigenetic reader protein Kaiso suppresses intestinal tumourigenesis in the Apc+/min mouse model, in which altered polarity plays a key role. Thus, we investigated the link between Kaiso deficiency, polarity and suppression of intestinal tumourigenesis. We used Kaiso deficient mice to conditionally delete Apc within the intestinal epithelia and demonstrated up-regulation of the spindle polarity genes Dlg1 and Dlgap1. To understand the role of Dlg1 we generated Villin-creApc+/minDlg1flx/flx Kaiso-/y mice to analyse gene expression, survival, tumour burden and spindle orientation. In vivo analysis of the Dlg1 deficient intestine revealed improper orientation of mitotic spindles and a decreased rate of cellular migration. Loss of Dlg1 decreased survival in Apc+/min mice, validating its role as a tumour suppressor in the intestine. Significantly the increased survival of Apc+/minKaisoy/mice was shown to be dependent on Dlg1 expression. Taken together this data indicates that maintenance of spindle polarity in the intestinal crypt requires appropriate regulation of Dlg1 expression. As Dlg1 loss leads to incorrect spindle orientation and a delay in cells transiting the intestinal crypt. We propose that the delayed exit from the crypt increase the window in which spontaneous mutations can become fixed, producing a “tumour-permissive” environment, without an increase in mutation rate.
Dietary nitrate and caffeine on cycling

The aim of this study was to examine the acute supplementation effects of dietary nitrate, caffeine, and their combination on 20 km cycling time-trial performance. Using a randomized, counterbalanced, double-blind, Latin-square design, 14 competitive, female cyclists (age: 31  7 years; height: 1.69  0.07 m; body mass: 61.6  6.0 kg) completed four 20 km time-trials on a racing bicycle fitted to a turbo-trainer. 2.5 hours before each trial, subjects consumed a 70 ml dose of concentrated beetroot juice containing either 0.45 g of dietary nitrate, or with the nitrate content removed (placebo). 1 hour before each trial, subjects consumed a capsule containing either 5 mgkg 1 of caffeine or maltodextrin (placebo). There was a significant effect of supplementation on power output (p = 0.001), with post hoc tests revealing higher power outputs in caffeine (205  21 W) versus nitrate (194  22 W) and placebo (194  25 W) trials only. Caffeine-induced improvements in power output corresponded with significantly higher measures of heart rate (caffeine: 166  12 vs. placebo: 159  15 b·min -1 ; p = 0.02), blood lactate (caffeine: 6.54  2.40 vs. placebo: 4.50  2.11 mmol·L -1 ; p < 0.001), and respiratory exchange ratio (caffeine: 0.95  0.04 vs. placebo: 0.91  0.05; p = 0.03). There were no effects (p ≥ 0.05) of supplementation on cycling cadence, ratings of perceived exertion, V̇O2, or integrated electromyographic activity. The results of this study support the well-established beneficial effects of caffeine supplementation on endurance performance. In contrast, acute supplementation with dietary nitrate appears to have no effect on endurance performance and adds nothing to the benefits afforded by caffeine supplementation.
CMAR_A_215533 7787..7803

Ying Zhang Jia-Yun Zou Zhe Wang Ying Wang 1Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, People’s Republic of China; 2Department of Pathology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, People’s Republic of China Abstract: Angiogenesis plays a critical role in the neoplastic growth, progression, and metastasis of colorectal cancer (CRC) in a process regulated by vascular endothelial growth factor (VEGF) family members and their receptors (VEGFR). Several small-molecule antiVEGFR tyrosine kinase inhibitors (TKIs), such as regorafenib, famitinib, axitinib and apatinib, have been shown to be effective in treating metastatic colorectal cancer (mCRC). Fruquintinib (ELUNATE) is a novel oral anti-VEGFR TKI, originated and developed by Hutchison MediPharma. Fruquintinib is a potent and highly selective small-molecule inhibitor of VEGFR-1, -2 and -3. In the Phase 3 FRESCO trial, fruquintinib improved both overall survival (OS) and progression-free survival (PFS) in patients with mCRC, compared with placebo. Fruquintinib also showed an acceptable safety and tolerability profile. Based on the data from this trial, fruquintinib was approved by the China Food and Drug Administration (CFDA) in 2018, for the treatment of patients with mCRC who had undergone at least two prior standard anticancer therapies. The existing clinical trials and future prospects of fruquintinib in mCRC will be discussed in this article. In addition, to better understand the role of fruquintinib in this setting, recent advances in other anti-VEGFR TKIs for mCRC treatment are also reviewed herein.
THE IMPACT OF INFLATION ON STOCK MARKET RETURNS AND VOLATILITY: EVIDENCE FROM NAIROBI SECURITIES EXCHANGE BY MURUNGI

The linkage between stock prices and inflation has been subjected to extensive research in the past decades and has aroused the interests of academics, researchers, practitioners and policy makers globally. This study examined the impact of inflation on stock market return and volatility in the Nairobi Securities Exchange (NSE). Previous research findings have established the existence of a negative relationship between a stock prices and inflation. These findings contradict the hypothesis by Fisher (1930) who argued that stock prices should be positively related with expected inflation, providing a hedge against inflation. A correlational research design was employed to establish whether inflation is associated with stock market return and volatility. Specifically, it sought to answer the question on the effect of inflation on the stock return and volatility in the NSE. Monthly time series data on NSE 20 share index and Consumer Price Index, for the period July 2000 to August 2012 was used in this research. The OLS estimation technique was employed to estimate a single equation relationship with the stock return as the dependent variable and explanatory variable as inflation. The coefficient for inflation from regression results is high at -0.38 implying that inflation is good at explaining the stock returns. The relationship between stock returns and inflation was found to be negative. This finding opposes the Fisher Hypothesis which states that the two variables are positively correlated in the sense that an increase in inflation leads to a proportional change in nominal market returns consequently hedging against inflation. The R-squared statistic measuring the success of the regression in predicting the values of the dependent variable within the