Miracle-dz/UniFAR-FTUs huggingface dataset:
The Association Between Adolescent Sexting, Psychosocial Difficulties, and Risk Behavior

When a sexting message spreads to an unintended audience, it can adversely affect the victim’s reputation. Sexting incidents constitute a potential school safety risk. Just as with other types of adolescent risk behavior, school nurses might have to initiate the first response when a sexting episode arises, but a school nurse’s role goes beyond intervention. They can also play an important role in the prevention of sexting and its related risks. This article reviews the links between adolescent sexting, other types of risk behavior, and its emotional and psychosocial conditions. Seven databases were examined and nine studies remained for further review. The review of the literature shows that adolescent sexting is cross sectionally associated with a range of health-risk behaviors. Youth who engage in sexting are also found to experience peer pressure and a range of emotional difficulties. The results can guide school nurse education and practice.
Primary cilia maintain corneal epithelial homeostasis by regulation of the Notch signaling pathway

Primary cilia have been linked to signaling pathways involved in cell proliferation, cell motility and cell polarity. Defects in ciliary function result in developmental abnormalities and multiple ciliopathies. Patients affected by severe ciliopathies, such as Meckel syndrome, present several ocular surface disease conditions of unclear pathogenesis. Here, we show that primary cilia are predominantly present on basal cells of the mouse corneal epithelium (CE) throughout development and in the adult. Conditional ablation of cilia in the CE leads to an increase in proliferation and vertical migration of basal corneal epithelial cells (CECs). A consequent increase in cell density of suprabasal layers results in a thicker than normal CE. Surprisingly, in cilia-deficient CE, cilia-mediated signaling pathways, including Hh and Wnt pathways, were not affected but the intensity of Notch signaling was severely diminished. Although Notch1 and Notch2 receptors were expressed normally, nuclear Notch1 intracellular domain (N1ICD) expression was severely reduced. Postnatal development analysis revealed that in cilia-deficient CECs downregulation of the Notch pathway precedes cell proliferation defects. Thus, we have uncovered a function of the primary cilium in maintaining homeostasis of the CE by balancing proliferation and vertical migration of basal CECs through modulation of Notch signaling. Summary: In the mouse corneal epithelium, primary cilia are confined to basal cells and modulate Notch signaling and cell proliferation to maintain normal epithelial thickness.
The internationalization of SMEs: developing and testing a multi-dimensional measure on Slovenian firms

The internationalization of small and medium-sized enterprises (SMEs) is explored by focusing on a clarification of the internationalization construct. A set of hypotheses is conceptually developed, including the main dimensions of internationalization (operation mode, market, product, time and performance). The proposed multi-dimensional internationalization construct is empirically tested.Questionnaire data were collected from a sample of 161 Slovenian SMEs. Scales were tested for reliability and validity. Key data analysis (confirmatory factor analyses and structural equation modelling) was conducted using the EQS structural equation modelling software.The multi-dimensionality of the developed SME internationalization construct is confirmed. The findings support the proposed SME internationalization hypotheses for the product, time and performance dimensions in full, and the operation mode and market dimensions in part. The proposed internationalization construct can be considered to be a valid measure of the internationalization of SMEs by capturing their multi-dimensionality.The new construct advanced in this study is richer than previous research and offers a relatively complete picture that can be used as a research framework in future examinations of internationalization. The developed internationalization construct advances SME internationalization theory and is informative for practitioners in developing SME internationalization programmes.
Sustained cardiac diastolic changes elicited by ultrafiltration in patients with moderate congestive heart failure: pathophysiological correlates.

OBJECTIVE--To investigate the pathophysiological (cardiac function and physical performance) significance of clinically silent interstitial lung water accumulation in patients with moderate heart failure; to use isolated ultrafiltration as a means of extravascular fluid reabsorption. DESIGN--Echocardiographic, Doppler, chest x-ray evaluations, and cardiopulmonary tests at baseline, soon after ultrafiltration (veno venous extracorporeal circuit), and four days, one month, and three months later. SETTING--University institute of cardiology. SUBJECTS--24 patients with heart failure due to idiopathic dilated cardiomyopathy or ischaemic myocardial disease with sinus rhythm and ejection fraction less than 35%. Twelve were randomised to ultrafiltration and 12 were taken as controls. MAIN OUTCOME MEASURES--Left ventricular systolic function (from ultrasonography); Doppler evaluation of mitral, tricuspid, and aortic flow and echo-Doppler determination of cardiac output; radiological score of extravascular lung water; right and left ventricular filling pressures; oxygen consumption at peak exercise and exercise tolerance time in cardiopulmonary tests. RESULTS--Soon after ultrafiltration (1976 (760) ml of fluid removed) the following was observed: a reduction in radiological score of extravascular lung water (from 15(1) to 9(1)) and of right (from 7.1 (2.3) to 2.3 (1.7) mm Hg) and left (from 17.6 (8.8) to 9.5 (6.4) mm Hg) ventricular filling pressures; an increase in oxygen consumption at peak exercise (from 15.8 (3.3) to 17.6 (2) ml/min/kg) and of tolerance time (from 444 (138) to 508 (134) s); a slight decrease in atrial and ventricular dimensions; no changes in the systolic function of the left ventricle; a reduction of the early to late filling ratio in both ventricles (mitral valve from 2 (2) to 1.1 (1.1)); (tricuspid valve from 1.3 (1.3) to 0.69 (0.18)) and an increase in the deceleration time of mitral and tricuspid flow, reflecting a redistribution of filling to late diastole. Variations in the ventricular filling pattern, lung water content, and functional performance persisted for three months in all cases. None of these changes was detected in the control group. CONCLUSIONS--Reduction of interstitial lung water was probably the mechanism whereby ultrafiltration modified the pattern of filling of the two ventricles and improved functional performance.
Influence of individual brightness and contrast adjustment on accuracy of radiographic measurements of infrabony defects.

OBJECTIVES To assess the accuracy of radiographic measurements of infrabony defects and to compare the accuracy with and without individual digital adjustment of brightness and contrast. METHODS In 41 periodontitis patients (19 females, 22 males; age range 23-73 years), 50 radiographs of 50 infrabony defects were obtained. All radiographs were digitized. Using a personal computer program, the linear distances between cemento-enamel junction (CEJ) and alveolar crest (AC) and between CEJ and bony defect (BD), and the depth of the infrabony defect (INFRA), were measured twice, according to the individual judgement of the radiographic examiner: (1) without digital adjustment (W) and (2) after use of contrast and brightness adjustment (A). Intrasurgical bone measurements served as the gold standard. The accuracy of measurements with or without digital adjustment was compared. RESULTS Radiographic measurements underestimated the gold standard for CEJ-BD (W: 1.1 mm ± 1.8 mm, P < 0.001; A: 1.0 mm ± 1.9 mm, P = 0.001). Both CEJ-AC (W: 0.2 mm ± 2.5 mm; A: 0.5 mm ± 2.6 mm) and INFRA (W: -0.4 mm ± 2.4 mm; A: -0.6 mm ± 2.5 mm) measurements came close to the gold standard. Statistically significant differences between W and A regarding accuracy were not observed. CONCLUSIONS The measurement tool used in this study provided high-accuracy measurements of periodontal bone loss in INFRA. Individual brightness and contrast adjustment failed to improve accuracy.
A Comparison of Outcomes and Dislocation Rates Using Dual Articulation Cups and THA for Intracapsular Femoral Neck Fractures

Total hip arthroplasty for intracapsular femoral neck fractures (FNF) is associated with a greater risk of dislocation. Dual articulation systems in this group of patients may provide better implant stability and a reduced dislocation rate. The aim of our study was to investigate FNF patients treated with dual articulation cups (DAC) and conventional THA and compare their clinical results at four months and one year after surgery. Our study compared femoral neck fracture patients treated with either DAC or conventional THA during two different time periods. Before surgery and during follow-up, the patients answered questions regarding their mobility, pain and usage of walking aids. Additionally at four-month and one-year follow-ups EQ-5D and HOOS questionnaires were applied for those patients qualifying for functional and quality of life analysis. Out of 125 femoral neck fracture patients 58 were treated with DAC and 67 with conventional THA. At four months and one year follow-up the HOOS and EQ-5D results did not differ significantly between DAC and conventional THA. Five hips in the THA group were revised for recurrent dislocation and two had a single dislocation. One year after surgery, the functional result of DAC and conventional THA are comparable but DAC have a lower risk of dislocation.
The Wide Distribution and Change of Target Specificity of R2 Non-LTR Retrotransposons in Animals

Transposons, or transposable elements, are the major components of genomes in most eukaryotes. Some groups of transposons have developed target specificity that limits the integration sites to a specific nonessential sequence or a genomic region to avoid gene disruption caused by insertion into an essential gene. R2 is one of the most intensively investigated groups of sequence-specific non-LTR retrotransposons and is inserted at a specific site inside of 28S ribosomal RNA (rRNA) genes. R2 is known to be distributed among at least six animal phyla even though its occurrence is reported to be patchy. Here, in order to obtain a more detailed picture of the distribution of R2, we surveyed R2 using both in silico screening and degenerate PCR, particularly focusing on actinopterygian fish. We found two families of the R2C lineage from vertebrates, although it has previously only been found in platyhelminthes. We also revealed the apparent movement of insertion sites of a lineage of actinopterygian R2, which was likely concurrent with the acquisition of a 28S rRNA-derived sequence in their 3′ UTR. Outside of actinopterygian fish, we revealed the maintenance of a single R2 lineage in birds; the co-existence of four lineages of R2 in the leafcutter bee Megachile rotundata; the first examples of R2 in Ctenophora, Mollusca, and Hemichordata; and two families of R2 showing no target specificity. These findings indicate that R2 is relatively stable and universal, while differences in the distribution and maintenance of R2 lineages probably reflect characteristics of some combination of both R2 lineages and host organisms.
Persistence, survival, and growth: a closer look at 20 years of fast-growing firms in Austria

This article studies the survival, persistence, and growth of fast-growing firms after their fast-growth period, using an extensive data set of Austrian firms. We use two definitions to identify fast-growing firms. High-growth firms (HGF) are firms with the highest growth rates, while high-Birch firms (HBF) are the firms that contribute most to job creation. Matching as nonparametric preprocessing is used to construct control groups consisting of firms that were similar in terms of size, age, and industry affiliation to the fast-growing firms. We run survival, persistence, and growth regressions on the balanced data sets. The results point to differences between the two definitions but also show similarities in outcomes. We find that HBFs have a substantially larger probability of repeating their fast-growth event than HGFs. For survival we find small differences between the definitions. With regard to firm growth, we find that growth after the high-growth period is rather modest for both definitions when compared with the growth rates achieved during the fast-growth episode. However, both HBFs and HGFs have much higher growth rates than control firms. Copyright 2014 The Author 2013. Published by Oxford University Press on behalf of Associazione ICC. All rights reserved. , Oxford University Press.
Determinants of Drug Disposition in Patients with Cirrhosis

The effects of alterations of the hepatic blood flow, the intrinsic clearance, and the anatomy of the portal circulation on drug disposition were investigated in 53 cirrhotic patients with portal hypertension using indocyanine green (ICG) and lidocaine as model drugs. ICG disposition was studied by sampling from an artery and one hepatic vein following i.v. injection, with determination of systemic and intrinsic clearances and hepatic blood flow. Lidocaine disposition was studied following i.v. and oral administration from peripheral vein disappearance curves, with determination of systemic and intrinsic clearances and systemic availability. The shunted fraction of intestinal blood flow (f) was measured from the combined ICG and lidocaine disposition studies. In the 53 patients, systemic clearances of ICG and lidocaine varied widely and were significantly correlated with each other (r = 0.725, p < 0.001). The systemic clearances of both ICG and lidocaine were not related to hepatic blood flow but were significantly correlated to their respective intrinsic clearances (for ICG: r = 0.948, p < 0.001; for lidocaine: r = 0.873, p < 0.001). Lidocaine systemic availability was also found to vary widely from 0.2 to 1.0. In 28 patients, f was <0.1 indicating minimal extrahepatic shunting and in these patients, lidocaine systemic availability was related to its intrinsic clearance (r = –0.717, p < 0.001); in the 25 other patients with significant extrahepatic shunting (f > 0.1), the extent of lidocaine systemic availability was related to both intrinsic clearance (r = −0.819, p < 0.001) and extrahepatic shunting (r = 0.913, p < 0.001). It is concluded that, in patients with cirrhosis: (i) the disposition of drugs with intermediate‐high hepatic extraction ratios is no longer influenced by hepatic blood flow but becomes limited by intrinsic clearance; and (ii) the decrease of intrinsic clearance plus extrahepatic shunting, when present, are responsible for the increased systemic availability of this type of drug.
The state of quality management in the Irish manufacturing industry

This study is part of a research programme on the implementation and implication of quality management in the Irish manufacturing industry. One of its main objectives is to identify an implementation order concerning tools and techniques. Data from survey show there has been continuous decline in the number of new ISO 9000 registrations in the manufacturing industry since reaching its peak some 4-5 years (up to and including survey year, 1996) ago. Statistically significant relationships exist between firms with ISO and those without ISO registration. The survey shows that a majority of the firms have ISO 9000 registration before successfully embracing and implementing total quality management (TQM). Empirical results show that there would be a marginal increase in performance over a 4-year and 6-year period, respectively, upon installing ISO and TQM programmes. This means that unless firms maintain and sustain the TQM drives continuously, there will be a decline in competitiveness. This paper concludes t.
Institutional Innovation and Public Extension Services Provision: The Marche Regional Administration Reform in Central Italy

Abstract This paper describes how Marche Regional Administration (MRA) introduced an innovative institutional reform of an Agricultural Knowledge and Information System (AKIS) in central Italy. In order to study the main features of the MRA reform we used a methodological approach based on three steps: (i) first we applied a desk analysis to sketch the main elements of the reform; (ii) we then analyzed farmers' assessment of the institutional change by using information derived from a field survey on a sample of beneficiaries, and (iii) using a focus group technique. We found that MRA reform introduced an institutional innovation in the domain of public extension services (ES) provision within the Italian context. However, the assessment of the short-term effects indicate that the original objectives of the reform have been only partially achieved. This is in line with other experiences presented in the literature and confirms the difficulties to introduce institutional innovation in the domain of AKIS. The paper describes the analysis of an institutional reform in the AKIS domain which has been considered a ‘best practice’ within the Italian context. Using an institutional analysis approach the paper provides an original way of looking at a ‘new’ model for organizing public ES.
Integrated Bi‐Layered Scaffold for Osteochondral Tissue Engineering

Osteochondral tissue engineering poses the challenge of combining both cartilage and bone tissue engineering fundamentals. In this study, a sphere‐templating technique was applied to fabricate an integrated bi‐layered scaffold based on degradable poly(hydroxyethyl methacrylate) hydrogel. One layer of the integrated scaffold was designed with a single defined, monodispersed pore size of 38 μm and pore surfaces coated with hydroxyapatite particles to promote regrowth of subchondral bone while the second layer had 200 μm pores with surfaces decorated with hyaluronan for articular cartilage regeneration. Mechanical properties of the construct as well as cyto‐compatibility of the scaffold and its degradation products were elucidated. To examine the potential of the biphasic scaffold for regeneration of osteochondral tissue the designated cartilage and bone layers of the integrated bi‐layered scaffold were seeded with chondrocytes differentiated from human mesenchymal stem cells and primary human mesenchymal stem cells, respectively. Both types of cells were co‐cultured within the scaffold in standard medium without soluble growth/differentiation factors over four weeks. The ability of the integrated bi‐layered scaffold to support simultaneous matrix deposition and adequate cell growth of two distinct cell lineages in each layer during four weeks of co‐culture in vitro in the absence of soluble growth factors was demonstrated.
Intellectual capital for organic growth: comparative analysis of two technology sectors

In this comparative analysis espousing resource-based view and contemporary research in intellectual capital, two groups of emerging technology-based companies respectively from the semiconductor and wireless application sectors were selected to review their pattern of capital allocations during their early years of growth and development. An intellectual capital flow framework was introduced to examine the interrelationship between financial capital and components of intellectual capital exemplifying conversion of external resources into enablers for organic growth within a technology-based company. Under such framework, statistical analysis was launched to explore the predictability of resource allocation for components of intellectual capital to generation of business growth among these enterprises that harnessed emerging technologies. The results suggested that particular combination of heterogeneous resources demonstrated through intellectual capital flow would construct positive impact on organic growth in time.
APELIN IN EPIRETINAL FIBROVASCULAR MEMBRANES OF PATIENTS WITH RETINOPATHY OF PREMATURITY AND THE CHANGES AFTER INTRAVITREAL BEVACIZUMAB

Purpose: Apelin, a novel cytokine, was reported to regulate angiogenesis. The aim of this study was to investigate the correlation between apelin and retinopathy of prematurity (ROP), between apelin and the other known angiogenic cytokines including vascular endothelial growth factor (VEGF) and hypoxia-induced factor-1a (HIF-1a). Methods: The study included 36 ROP patients who underwent vitrectomy. Previous intravitreal bevacizumab (IVB) was performed in 18 patients (IVB group). The other ROP eyes belonged to non-IVB group. Surgical removed membranes from 10 patients who underwent vitrectomy for idiopathic preretinal membranes or macular hole served as control. The expression of apelin and angiotensin-1–like receptor (APJ) in the excised membranes was examined by fluorescence immunostaining. Quantitative reverse transcription polymerase chain reaction was used to examine the expression of apelin, VEGF, and HIF-1a mRNA. Results: The density of neovascularization in fibrovascular membranes was significantly correlated with the age and postconception age of ROP patients (r = −0.94, P < 0.01; r = −0.83, P = 0.04). In the non-IVB group, colocalization of the endothelial marker CD31 with the marker for apelin and colocalization of CD31 and APJ were observed. In the IVB group, staining of apelin and APJ were positive, whereas the staining of CD31 was negative. Expression of apelin mRNA, HIF-1a mRNA, and VEGF mRNA were significantly higher in ROP membranes than idiopathic epiretinal membranes. Expression of apelin mRNA and VEGF mRNA significantly correlate with HIF-1a mRNA (r = 0.64, P = 0.04; and r = 0.96, P < 0.01, respectively), but the expression of apelin mRNA did not significantly correlate with VEGF mRNA (r = 0.491, P = 0.15). Conclusion: The apelin/APJ system may be involved in the development of retinal neovascularization of ROP. The present results showed that the effect of apelin was related to HIF-1a but independent with VEGF.
Consideration of Retirement Income Stages in Planning for Retirement

Previous retirement adequacy studies have ignored expected retirement income stages. Ignoring retirement income stages results in biased estimations of retirement adequacy. This study analyzes retirement income stage theoretically and then empirically. Based on the 1995 to 2007 Survey of Consumer Finances (SCF) datasets, about 73% of working households with the head and/or spouse/partner age 35-70 and working full-time will have more than one retirement income stage. When income stages are taken into account, the proportion of households with retirement adequacy ranges from 44% in 1995 to 58% in 2007. Ignoring retirement income stages results in adequacy proportions being 23 to 28 percentage points higher. Financial planners and researchers evaluating retirement adequacy should take retirement income stages into account.