Miracle-dz/UniFAR-FTUs huggingface dataset:
Motivations for participating in Wine Tourism Activities- the case of Tourists on the ThraceWine Route in Turkey

Wine tourism is developing in parallel with the increasing number of individuals who take part in alternative tourism and is frequently approached within specialty tourism in the academic literature, being growing worldwide. While countries like Portugal, Spain, and particularly Italy and France, are already recognized wine tourism destinations, in recent years, countries like Bulgaria, Bosnia and Herzegovina and Turkey have also increasingly invested in this specialty tourism form. One crucial factor of success of wine tourism is the development of wine routes presenting appealing and diversified experiences around the theme of wine production and culture. Co-creation of these experiences is also an important topic, since the active participation of wine tourists has been suggested as highly involving and memorable for these thematic and local-resource-based rural tourism experiences (Kastenholz, Carneiro & Marques, 2012). Especially, activities that permit interested tourists to taste different sorts of wine, even engage with the wine harvesting and/ or production process and wine routes that provide outstanding tourist attractions catch the attraction of wine enthusiasts all over the world. Today, the growing number and diversity of wine routes, especially those in the Eastern Europe, is attracting many individuals who want to engage in a variety of wine tourism experiences. Wine tourism development that especially targets tourists with high disposable income and willingness to spend on special wine tourism experiences and on wine purchase is considered a most interesting strategy, enhancing the region’s economic development stimulating both the tourism and wine production sector.
Huntington's Disease: Update and Review of Neuropsychiatric Aspects

Objective: This article presents a general update on Huntington's disease (HD) and reviews the psychiatric and cognitive features of this disorder. Method: HD is discussed in five sections: an introduction and update, the psychiatric aspects, the cognitive aspects, brain-behavior relationships, and the differential diagnosis and management. Results: Recent advancements in HD include the identification of presymptomatic testing methods and HD gene defect, structural and metabolic neuroimaging findings, and a neuropsychological profile. HD is associated with mood disorders, personality changes, irritable and explosive behavior, a schizophrenia-like illness, suicidal behavior, sexuality changes, and specific cognitive deficits. Conclusions: HD results in organic mental disorders from dysfunction of prefrontal-subcortical circuits coursing through the caudate nuclei. The diagnosis of HD is aided by genetic testing, neuroimaging, and neuropsychological testing. Management involves education, genetic counseling, and psychotropic medications. Finally, the future of HD holds promise for the development of rational, neurobiologically-based treatments and genetically engineered therapies.
Children with Tonsillar Obstruction: Indications for and Efficacy of Tonsillectomy

ABSTRACT. One hundred and twenty‐two children between 1 1/2 and 14 years of age with symptoms suggesting tonsillar obstruction have been investigated. Each patient's history was analysed and the symptoms scored according to their incidence and severity. In addition, the size of the tonsils was evaluated. Eighty‐five patients were chosen for tonsillectomy. The children with signs and symptoms of tonsillar obstruction improved greatly immediately after tonsillectomy. Severe symptoms of obstruction were observed in children with nearly normal tonsil size, as well as in those with very large tonsils. It is therefore just as important to obtain a careful history as it is to evaluate the size of the tonsils before deciding about surgery.
Financial charity giving behaviour of the working poor: an empirical investigation

ABSTRACT Although it is well-known that, on the average, financially poor individuals donate higher percentages of their incomes to charity than do the financially well-off, little research has been completed into possible differences in the financial giving behaviour of poor people in employment (the working poor) and poor individuals of working age who do not work. The present study addresses this issue via a survey of working and unemployed poor people in three low-income Boroughs in inner-London: Newham, Hackney and Tower Hamlets. It is hypothesised that disparities can be explained by, among other things, factors connected with a poor person’s sense of engagement with the wider society; in conjunction with an individual’s experiences and perceptions of social deprivation. Outcomes to the investigation suggest that the working poor tend to exhibit attitudes and behaviour more similar to those of the financially better-off than to the non-working poor, and that their affinity with the better-off extends to their donating lower percentages of their incomes to charity than the unemployed poor.
Exploring factors which motivate older consumers’ self-service technologies (SSTs) adoption

ABSTRACT Although the proportion of the older population is growing, the majority of research on technology adoption behaviour, such as the adoption of self-service technologies (SSTs), tends to focus on younger consumers. To fill this gap, this study is designed to explore factors which motivate older consumers’ adoption of SSTs by applying Gatignon and Robertson’s diffusion process model. Responses were collected from 104 respondents who were aged 55 or over and who had used self-checkouts in the past. The data were analysed using partial least squares path modelling with SmartPLS 3.0 software. The results indicate that perceptions of SST characteristics, including usefulness, enjoyment, and control, are indirect antecedents of older consumers’ SST adoption through service quality and/or perceived risk. Another key predictor of older consumers’ adoption of SST is prior usage experience with SSTs, which strongly influences usefulness and compatibility. Findings from this study contribute to the literature because little research has explored what drives older consumers to use SSTs.
Analysis of integrated hepatitis B virus DNA and flanking cellular sequences in a childhood hepatocellular carcinoma

The DNA of tumor tissue K1 obtained at autopsy from a case of hepatocellular carcinoma (HCC) in a 9‐year‐old boy contained integrated hepatitis B virus (HBV) DNA at a single site in the chromosome (case 2, Chang et al.: Hepatology 13:316‐320, 1991). To characterize further the integrated viral DNA sequences, a genomic library of the K1 DNA was constructed in the lambda L47.1 vector. One phage clone, designated KTM‐1, containing integrated HBV DNA and cellular flanking sequences was obtained from this library. The restriction map and DNA sequence of this clone showed that the integrated HBV DNA was partially deleted and rearranged. The most conserved viral DNA sequences were surface and X genes and arranged in the opposite orientation. The viral core gene was not present. Using chloramphenicol acetyltransferase (CAT) assay, the C‐terminal truncated X open reading frame was demonstrated to retain its trans‐activating ability. The result suggested that the functional integrated X gene may play a role in hepatocarcinogenesis. The study also showed that the right cellular flanking sequences were human alphoid repetitive sequences. © 1994 Wiley‐Liss, Inc.
Leukoencephalopathy-related cerebral amyloid angiopathy with cystatin C deposition.

BACKGROUND We have described sporadic cases of cerebral amyloid angiopathy with cerebral hemorrhage showing a low cystatin C level in the cerebrospinal fluid detected by enzyme-linked immunosorbent assay. Recently, several cases of leukoencephalopathy in patients with cerebral amyloid angiopathy have been reported. We describe a sporadic case of leukoencephalopathy with cystatin C-type cerebral amyloid angiopathy diagnosed during life by enzyme-linked immunosorbent assay. CASE DESCRIPTION A 74-year-old man who had suffered from progressive dementia for 3 years was admitted with right hemiparesis, dysarthria, and ataxia. MRI revealed pontine infarction and multiple lacunar state with leukoaraiosis. We suspected cystatin C-type cerebral amyloid angiopathy because of the low level of cystatin C in the cerebrospinal fluid. The patient died of sepsis 3 months later, and the presence of leukoencephalopathy with cerebral amyloid angiopathy was confirmed by autopsy. Immunohistological examination disclosed cystatin C and beta-protein deposition in amyloid structures of the cortical cerebral arteries. CONCLUSIONS Measurement of cystatin C in the cerebrospinal fluid by enzyme-linked immunosorbent assay is a useful method of diagnosing leukoencephalopathy related to sporadic cystatin C-type cerebral amyloid angiopathy.
Body Objectification and Depression in Adolescents: The Role of Gender, Shame, and Rumination

Objectification theory posits that the tendency to view oneself as an object to be looked at and evaluated by others negatively affects girls', but not boys', subjective well-being. Although it has been established that women self-objectify more than men, research in this area has been limited to the study of adult college women. The aim in the current longitudinal study was to investigate the role of body shame and rumination in the link between self-objectification and depression among a community sample of girls and boys at ages 11 and 13. Results indicated that adolescent girls reported higher levels of self-objectification, body shame, rumination, and depression than boys. The findings support a model in which body shame and rumination mediate a direct relation between self-objectification and depression among girls; developmentally, the gender difference in self-objectification appears before the gender differences in rumination and depression.
Tobacco and alcohol use outcomes of a school-based intervention in New Delhi.

OBJECTIVE To reduce tobacco use among adolescents. METHODS Thirty schools in New Delhi, India, were randomly assigned to 3 conditions: school-based and family-based intervention, school-based intervention only, or control group. Students were in the seventh grade at pretest (N = 4,776). The smoking intervention included posters, booklets, classroom activities, debates, and a signature campaign. The family intervention involved home activities. The survey measured tobacco knowledge, attitudes, offers, use, and intentions. RESULTS Intervention students were significantly less likely than controls to have been offered, received, experimented with, or have intentions to use tobacco. CONCLUSION The project had a significant impact on tobacco use.
Popcorn Flavoring Effects on Reactivity of Rat Airways in Vivo and in Vitro

“Popcorn workers' lung” is an obstructive pulmonary disease produced by inhalation of volatile artificial butter flavorings. In rats, inhalation of diacetyl, a major component of butter flavoring, and inhalation of a diacetyl substitute, 2,3-pentanedione, produce similar damage to airway epithelium. The effects of diacetyl and 2,3-pentanedione and mixtures of diacetyl, acetic acid, and acetoin, all components of butter flavoring, on pulmonary function and airway reactivity to methacholine (MCh) were investigated. Lung resistance (RL) and dynamic compliance (Cdyn) were negligibly changed 18 h after a 6-h inhalation exposure to diacetyl or 2,3-pentanedione (100–360 ppm). Reactivity to MCh was not markedly changed after diacetyl, but was modestly decreased after 2,3-pentanedione inhalation. Inhaled diacetyl exerted essentially no effect on reactivity to mucosally applied MCh, but 2,3-pentanedione (320 and 360 ppm) increased reactivity to MCh in the isolated, perfused trachea preparation (IPT). In IPT, diacetyl and 2,3-pentanedione (≥3 mM) applied to the serosal and mucosal surfaces of intact and epithelium-denuded tracheas initiated transient contractions followed by relaxations. Inhaled acetoin (150 ppm) exerted no effect on pulmonary function and airway reactivity in vivo; acetic acid (27 ppm) produced hyperreactivity to MCh; and exposure to diacetyl + acetoin + acetic acid (250 + 150 + 27 ppm) led to a diacetyl-like reduction in reactivity. Data suggest that the effects of 2,3-pentanedione on airway reactivity are greater than those of diacetyl, and that flavorings are airway smooth muscle relaxants and constrictors, thus indicating a complex mechanism.
The Effect of Music Therapy for Patients With Huntington＇s Disease： A Systematic Literature Review

Huntington’s disease is a progressive, neurodegenerative, and autosomal dominant disease characterized by motorand psychiatric disturbances, and cognitive decline. Since there is no cure, all treatment is aimed at improving quality of life. One form of non-drug therapy which is barely recognized, is music therapy. The literature on its use and effect in patients with Huntington’s disease is limited. We therefore performed a detailed literature survey in order to delineate the different types of music therapy interventions and their aims. Music therapy studies were included when targeting: (1) motor disturbances; (2) cognitive disturbances; (3) psychiatric disturbances; and (4) emotional/social disturbances. A total of eight studies that met these criteria were analyzed. We found that music therapy interventions vary throughout the different stages of the disease and are not yet applied optimally. Not the stage of the disease but the individual treatment goals seem to be more determinative for the music therapy indications. In conclusion, precise aims and methods in relation to the stage of the disease are not well determined. There is a need for systematic study of this treatment option.
Evaluation of cuffed tracheal tube size predicted using the Khine formula in children

Background: The correct size of cuffed endotracheal tube (CET) limits the risk of postintubation tracheal damage. The aim of this study was to compare the size of the CET used in children with the size predicted by the Khine formula [age (years)/4 + 3].
Examining the relationship between commuting patterns, employment growth and unemployment in the Sydney Major Statistical Region

The paper will develop a framework to understand how employment growth and commuting patterns (modelled using Journey to Work data) interact to determine the spatial distribution of unemployment in the Statistical Local Areas within the Sydney MSR. We seek to explore how the benefits of employment growth are distributed across space. Employment change over time across urban areas is resolved by a combination of labour market responses summarised as: (a) changes in the local employment of residents, which can incorporate net in or out-migration; and (b) changes in the level of net in- or out-commuting. In areas of employment stagnation or decline, the capacity of some residents to avoid long term unemployment will be dependent on their ability to secure jobs elsewhere in the urban area and either out-commute or relocate. The labour market accounts (LMA) framework is employed to decompose these labour market responses in the period 1996-2001 in the Sydney MSR. Regression models are estimated to consider the relative strength of the relationships between each of these labour market adjustment responses and percentage employment change. Separate models are estimated for males and females to test whether the adjustment processes of each are different. We also augment the regressions with a variable representing occupational structure to determine whether the initial occupational structure of an area impacts on the adjustment process. The results highlight clear differences between males and females. The results show emphatically that employment growth between 1996 and 2001 has elicited substantial changes in commuting behaviour. Women, surprisingly, showing relatively greater in-commuting responsiveness to employment growth. Unemployment changes in local areas are swamped by commuting responses.
Organizational Resources and Performance of Kenyan State Corporations

Organizational resources have been posited to influence organizational performance. However, this position has been largely tautological with need for more empirical grounding. The postulations of resource based theory confer a significant effect of resources on organizational performance only when they possess some strategic characteristics. In spite of this postulation, comparative management advances an argument that management is sensitive to the context in which it is practiced; hence empirical testing of the postulation is inconclusive. This study tested the influence of organizational resources on the performance of Kenyan state corporations. Through a crosssectional descriptive survey, data on resources and performance were obtained from 63 Kenyan state corporations and analyzed using both descriptive and inferential statistics. The findings report a statistically significant relationship between aggregated organizational resources and performance. However, organizational resources could only explain 8.3 percent of performance of Kenyan state corporations. Results of the independent effect of disaggregated organizational resources indicated statistically significant effect of tangible, human and intangible resources on performance. Statistically not significant results were reported for the effect of organizational capabilities on performance. The findings provide partial empirical support for the Resource Based Theory by supporting the postulations that resources possessed by an organization influence performance by establishing the independent contributions of each resource to performance. It has offered direction for dayto- day managerial practice as well as policy direction at both organizational and government levels. At managerial level, practitioners may consider strengthening resource integration, renewal as well as recombination for stellar performance. Government policy should be focused towards encouraging resource acquisition, integration, configuration, and combination that would have a stronger influence on performance. From the limitations of the study, areas for further research have been pointed out.
Heuristic Pricing in an Uncertain Market: Ecological and Constructivist Rationality

How do firms set prices when faced with an uncertain market? Analyzing the pricing strategies of used car dealers using online data and interviews, we find that dealers employ an aspiration level heuristic similar to a Dutch auction. At the same time, the aggregate market is well described by a model of equilibrium price dispersion. Unlike the equilibrium model, the heuristic correctly predicts systematic pricing characteristics such as high initial price, price stickiness, and the “cheap twin paradox. ” We also find first evidence that heuristic pricing can generate higher profits given uncertainty than the equilibrium strategy.
International Financial Reporting Standards Adoption and Value Relevance of Financial Information of Quoted Healthcare Firms in Nigeria

International Financial Reporting Standards (IFRS) was first adopted in 2005 by European Union countries while Nigeria mandatorily adopted in 2012 to participate in opportunities offered by globalization. This study, therefore, investigated the impact of IFRS adoption on the value relevance of financial information of quoted Healthcare Firms in Nigeria. The study conducted a pre (2008-2011) and post (2012-2015) IFRS analyses on six Healthcare firms quoted on the Nigeria Stock Exchange. The study sourced data on Earnings per Share (EPS), Change in Earnings per Share (CEPS), Book Value per Share (BVPS) and Share Price (SP) from published annual reports of the quoted Healthcare firms and Cashcraft Asset Management. Using the Multiple regression model the study revealed that Pre- IFRS financial information is value relevant; Post-IFRS financial information is also value relevant; and Post-IFRS financial information has relative value relevance over Pre- IFRS financial information.
Sex-Related Injury Patterns among Selected High School Sports

This cohort observational study was undertaken to test the hypothesis that the incidence of injuries for girls participating in high school sports is greater than that for boys. From 1995 through 1997, players were included in our study if they were listed on the school's varsity team roster for boys’ or girls’ basketball, boys’ or girls’ soccer, boys’ baseball, or girls’ softball. Injuries and opportunities for injury were recorded daily. Certified athletic trainers reported injury and exposure data. Based on 39,032 player-seasons and 8988 reported injuries, the injury rates per 100 players for softball (16.7) and for girls’ soccer (26.7) were higher than for baseball (13.2) and boys’ soccer (23.4). The knee injury rates per 100 players for girls’ basketball (4.5) and girls’ soccer (5.2) were higher than for their male counterparts. Major injuries occurred more often in girls’ basketball (12.4%) and soccer (12.1%) than in boys’ basketball (9.9%) and soccer (10.4%). Baseball players (12.5%) had more major injuries than softball players (7.8%). There was a higher number of surgeries, particularly knee and anterior cruciate ligament surgeries, for female basketball and soccer players than for boys or girls in other sports.
Cohesive motion in one-dimensional flocking

A one-dimensional rule-based model for flocking, which combines velocity alignment and long-range centering interactions, is presented and studied. The induced cohesion in the collective motion of the self-propelled agents leads to unique group behavior that contrasts with previous studies. Our results show that the largest cluster of particles, in the condensed states, develops a mean velocity slower than the preferred one in the absence of noise. For strong noise, the system also develops a non-vanishing mean velocity, alternating its direction of motion stochastically. This allows us to address the directional switching phenomenon. The effects of different sources of stochasticity on the system are also discussed.
Chromatin Contributes to Structural Integrity of Promyelocytic Leukemia Bodies through a SUMO-1-independent Mechanism*

Promyelocytic leukemia (PML) protein is implicated in transcriptional regulation, apoptosis, DNA repair, and tumor suppression. It is not known, however, whether PML and other components of PML bodies function within the vicinity of the bodies or elsewhere in the nucleoplasm. In this study, we demonstrate that chromatin organization around PML bodies influences their morphology, dynamics, and structural integrity by a SUMO-1-independent mechanism. Following transcriptional inhibition and during early apoptosis, chromatin retracts from the periphery of PML bodies, coinciding with the formation of new PML-containing structures through fission of supramolecular PML-containing microbodies. Both fission and fusion of microbodies with parental PML bodies indicate a loss of structural integrity of the bodies, dependent on the state of the surrounding chromatin. This is supported by the observation that treatment of live cells with DNase I could reproduce the structural instability of PML bodies. In addition, PML bodies, which are normally surrounded by chromatin and are positionally stable, become more dynamic following these treatments, presumably due to the loss of chromatin contacts. Overexpression of SUMO-1, a modification required for PML body formation, did not prevent PML body fission, indicating that chromatin-based integrity of PML body structure occurs through a SUMO-1-independent mechanism.