Miracle-dz/UniFAR-FTUs huggingface dataset:
Analysis of Comparison of Human Meibomian Lipid Films and Mixtures with Cholesteryl Esters In Vitro Films using High Resolution Color Microscopy.

PURPOSE The lipid layer of the tears has been studied in vivo using high resolution color microscopy (HRCM). The purpose of these experiments was to gain further insight into the structure of the lipid layer by applying HRCM to in vitro meibomian lipid films. METHODS Films of human meibomian lipids, cholesteryl nervonate, cholesteryl palmitate, or their mixtures, were spread on a Langmuir trough. Changes to the films were monitored using HRCM as the films were compressed to different surface pressures. The penetration of albumin into a meibomian lipid film also was studied. RESULTS Small amounts of meibomian lipids at low pressures formed very thin films estimated to be 5.2 nm thick. Compression caused spots to appear in the films. At higher concentrations, micro lenses were a feature of the film. Cholesteryl nervonate formed a multilayered oil slick that did not change with surface pressure. Cholesteryl palmitate formed a stiff film that collapsed at high compression. Mixtures of cholesteryl nervonate and meibomian lipids showed that they mixed to increase surface pressures above that of the individual components. HRCM also allowed albumin to be seen penetrating the meibomian lipid film. CONCLUSIONS HRCM combined with in vitro surface pressure measurements using a Langmuir trough is useful for modeling meibomian lipid films. The films often resemble the appearance of the lipid layer of in vivo films. The data indicate that the lipid layer might be modeled best as a duplex film containing an array of liquid crystals.
Uncleaved BAP31 in Association with A4 Protein at the Endoplasmic Reticulum Is an Inhibitor of Fas-initiated Release of Cytochromec from Mitochondria*

BAP31 is a polytopic integral protein of the endoplasmic reticulum membrane and, like BID, is a preferred substrate of caspase-8. Upon Fas/CD95 stimulation, BAP31 is cleaved within its cytosolic domain, generating proapoptotic p20 BAP31. In human KB epithelial cells expressing the caspase-resistant mutant crBAP31, Fas stimulation resulted in cleavage of BID and insertion of BAX into mitochondrial membrane, but subsequent oligomerization of BAX and BAK, egress of cytochrome c to the cytosol, and apoptosis were impaired. Bap31-null mouse cells expressing crBAP31 cannot generate the endogenous p20 BAP31 cleavage product, yet crBAP31 conferred resistance to cellular condensation and cytochrome c release in response to activation of ectopic FKBPcasp8 by FK1012z. Full-length BAP31, therefore, is a direct inhibitor of these caspase-8-initiated events, acting independently of its ability to sequester p20, with which it interacts. Employing a novel split ubiquitin yeast two-hybrid screen for BAP31-interacting membrane proteins, the putative ion channel protein of the endoplasmic reticulum, A4, was detected and identified as a constitutive binding partner of BAP31 in human cells. Ectopic A4 that was introduced into A4-deficient cells cooperated with crBAP31 to resist Fas-induced egress of cytochrome c from mitochondria and cytoplasmic apoptosis.
Building Destination Loyalty Using Tourist Satisfaction and Destination Image: A Holistic Conceptual Framework

Regardless of the value of destination loyalty in both academia and industry, the conceptual development of literature is restricted. This present work seeks to build up a holistic conceptual framework responds to how tourist perception, destination image, satisfaction, and often related attributes can play the main role in destination loyalty. By analyzing the above crucial factors and highlight its implication in destination loyalty. In addition, provide insight into the creation of destination image and in further stage tourist loyalty. The holistic conceptual framework is developed within this research endeavour. The conceptual framework is articulated as one might hope based on tourist demand and supply factors and tourist perception, destination image (organic, induced, and complex image), and the above crucial factors comprising tourist loyalty and how each one of them can be more interactive. The outcomes of the study achieve remarkable theoretical and managerial implications for destination marketing supervisors.
Factors influencing participation of cassava farmers in survival farming intervention programme in Kogi State, Nigeria

This study assessed the factors influencing participation of cassava farmers in Survival Farming Intervention Programme (SFIP) in Kogi State, Nigeria. A multi-stage sampling procedure was used to select 180 respondents comprising of cassava grower in the study area. Primary data were collected with the aid of questionnaire complemented with interview schedule. Both descriptive (frequency count, percentages and mean) and inferential (Logit regression) statistics were used to analyse the data collected. Results revealed that the majority (72.8%) of the respondents were within the age range of 36 – 55 years, while 94.5% the respondents were married. The majority (68.4%) of the respondents acquired formal education, while 31.6% had no formal education. In term of access to SFIP activities, the majority (61.7%) of the respondents were aware of SFIP, 65.6% were visited by extension agents under the programme, 73.3% were member of cooperative society and 58.3% of the respondents had access to credit as introduced under the programme. Major constraint identified by the respondents was poor market for produce (83.9%) ranked 1 st among other constraints. Logit regression analysis shows that with Pseudo-R 2 of 0.68, 68% of the variation in the participation in SFIP was explained by the independent variables in the model. Age (3.26), labour (2.88), education (2.53), land tenure (-2.60), awareness (5.45), extension contact (2.62) and planting material (2.80) were significant at 1% probability level, while marital status (2.47) and gender (-2.37) were significant at 5% probability level and they statistically influence participation in SFIP. In conclusion, most of the respondents were aware of SFIP and benefited from its activities. It was therefore recommended that rural markets should be linked to the urban market to attract good value for cassava products thereby enhancing living standard of the farmers especially those in the rural areas. Keywords: Cassava farmers, Intervention programme, Variables
Flutroline in the Treatment of the Schizophrenic Patient

Abstract: As an introduction into a clinical study of one of a new group of compounds having neuroleptic potential, the background and characteristics of the gamma carbolines, particularly flutroline, are cited in the general context of a review of the use of antipsychotic drugs in psychiatry. In the four‐week double‐blind trial involving dosages of 1, 5, 10, 20 and 100 mg, 48 hospitalized schizophrenic patients were given the tryptoline derivative flutroline on a once‐a‐day basis. Outcome criteria obtained weekly, including the incidence of side effects, standardized psychiatric ratings, and clinical global impressions of psychopathology, indicated that flutroline was a safe and effective antipsychotic drug. Data suggested that dosages of 20 mg and above offered the best potential for optimal clinical effectiveness.
User acceptance of E-Government Services Based on TRAM model

Developing country mostly left behind in adopting e-Government system. Miss-interpretation is assuming e-Government only about the application of technology made fail implementation. It is a whole philosophy that explores a human-citizen centered aspect in organized societies. Further, successful information system determined by user acceptance. Therefore, the evaluation of the performance of e-Government is one of the basic objectives of current government reformation. The research focus is to identify and explore the extent of user acceptance toward e-Government system. The research methodology used in this research is survey based on a questionnaire with TRAM approach and distributed to 230 respondents as customers that had been using e-Government services provided by X institution. The result of the study showed that the personality traits of TR significantly influenced cognitive dimensions of TAM. Through empirical demonstrations indicated that the TRI was said to be antecedents to TAM. The optimism dimension had higher coefficient among others, exhibit the technology users convince that the new technology will improve their productivity, while discomfort had no impact since the users have no doubt or hesitate to use technology.
Algorithmes d'ensemble actif pour le LASSO

Le LASSO est une methode de regression ajoutant a la methode des moindres-carres une contrainte ou une penalisation sur la norme l1 du coefficient lineaire. Cette contrainte a un effet de selection de variable et de regularisation sur l'estimateur. Un estimateur LASSO est defini comme etant la solution d'un probleme pouvant etre vu comme un programme quadratique. Cette these se base sur deux algorithmes dedies a la resolution du LASSO publies en 2000 par M. Osbourne et alii. L'un, une methode par homotopie, a ete reformule en 2004 par J. Friedman et alii sous le nom de LAR-LASSO (ou LARS), s'imposant alors comme la methode standard. Le second, presente comme une methode d'ensemble actif, fut largement ignore, semble-t-il pour deux raisons: une application apparemment limitee a la formulation "contrainte", et une comprehension plus difficile de l'algorithme. Nous reformulons donc le principe general du second, que nous baptisons "Descente sur Ensemble Actif" (DEA) et sa derivation sur le LASSO, ainsi que la methode par homotopie que nous mettons en evidence comme directement derivee de la DEA. La formulation simplifiee des deux methodes permet d'en ameliorer la comprehension, mais aussi l'efficacite en temps de calcul. Elle met en outre en evidence l'applicabilite de la DEA sur la formulation "penalisee" du LASSO, donnant un algorithme plus simple encore. Enfin, elle conduit a une analyse et un traitement de cas limites dans lesquels ces algorithmes peuvent echouer. Nous proposons ensuite une application directe du LASSO sur un nombre infini de variables formant un espace multidimensionel, et etudions l'adaptation des algorithmes d'ensemble actifs dans ce cadre.
Physical design of fusion based on generative adversarial networks

The physical design of fusion is a key part of achieving controlled thermonuclear fusion. The physical design of fusion is divided into three important parts. These are the structural design, the material properties and the physical processes. These three components form a structural design file, a material properties file and a physical process file, which are fed into a configuration operation to generate an adversarial network to determine the final process parameters. The process parameters can be used for the physical design and fabrication of the fusion target as well as for the overall fusion experiments. The fusion physics model obtained by GAN has an output energy of up to 300 MJ, a gain of up to 30 and a neutron yield of 1017-1019, which meets the conditions for fusion ignition.
Identification of Immune Effectors Essential to the Control of Primary and Secondary Intranasal Infection with Brucella melitensis in Mice

The mucosal immune system represents the first line of defense against Brucella infection in nature. We used genetically deficient mice to identify the lymphocytes and signaling pathways implicated in the control of primary and secondary intranasal infection with B. melitensis. Our analysis of primary infection demonstrated that the effectors implicated differ at the early and late stages and are dependent on the organ. TCR-δ, TAP1, and IL-17RA deficiency specifically affects early control of Brucella in the lungs, whereas MHC class II (MHCII) and IFN-γR deficiency impairs late control in the lungs, spleen, and liver. Interestingly, IL-12p35−/− mice display enhanced Brucella growth in the spleen but not in the lungs or liver. Secondary intranasal infections are efficiently contained in the lung. In contrast to an i.p. infectious model, in which IL-12p35, MHCII, and B cells are strictly required for the control of secondary infection, we observed that only TCR-β deficiency or simultaneous neutralization of IL-12p35– and IL-17A–dependent pathways impairs the memory protective response against a secondary intranasal infection. Protection is not affected by TCR-δ, MHCII, TAP1, B cell, IL-17RA, or IL-12p35 deficiency, suggesting that CD4+ and CD8+ α/β+ T cells are sufficient to mount a protective immune response and that an IL-17A–mediated response can compensate for the partial deficiency of an IFN-γ–mediated response to control a Brucella challenge. These findings demonstrate that the nature of the protective memory response depends closely on the route of infection and highlights the role of IFN-γ–and IL-17RA–mediated responses in the control of mucosal infection by Brucella.
Are Short Selling Restrictions Effective?

Despite strong theoretical predictions based on disagreement, limited empirical evidence has linked short selling restrictions to higher prices. We test this relationship using quasi-experimental methods based on Rule 201, a threshold-based policy that restricts aggressive short selling when intraday returns cross -10%. When comparing stocks on either side of the threshold in the same hour of trading, we find that the restriction leads to 8% lower short sale volume and 35 bps higher daily returns. These price effects do not reverse and are not associated with information events, suggesting that Rule 201 restricts short selling based on transient opportunities unrelated to fundamentals. Although these persistent direct effects align with policymaker objectives, we find evidence of offsetting transient spillover effects on peer stocks consistent with cross-stock substitution by short sellers.
POLYCYCLIC AROMATIC HYDROCARBONS IN GALAXIES AT z ∼ 0.1: THE EFFECT OF STAR FORMATION AND ACTIVE GALACTIC NUCLEI

We present the analysis of the polycyclic aromatic hydrocarbon (PAH) spectra of a sample of 92 typical star-forming galaxies at 0.03 < z < 0.2 observed with the Spitzer intensified Reticon spectrograph (IRS). We compare the relative strengths of PAH emission features with Sloan Digital Sky Survey optical diagnostics to probe the relationship between PAH grain properties and star formation and active galactic nuclei (AGNs) activity. Short-to-long wavelength PAH ratios, and in particular the 7.7 μm-to-11.3 μm feature ratio, are strongly correlated with the star formation diagnostics Dn(4000) and Hα equivalent width, increasing with younger stellar populations. This ratio also shows a significant difference between active and non-active galaxies, with the active galaxies exhibiting weaker 7.7 μm emission. A hard radiation field as measured by and effects PAH ratios differently depending on whether this field results from starburst activity or an AGN. Our results are consistent with a picture in which larger PAH molecules grow more efficiently in richer media and in which smaller PAH molecules are preferentially destroyed by the AGN.
A preliminary attempt to experimentally induce post event processing in social anxiety disorder.

BACKGROUND Post event processing (PEP) in social anxiety disorder involves rumination about social events after the fact, and is thought to be a crucial feature of the maintenance of the disorder. AIMS The current experiment aimed to manipulate the use of PEP in individuals with social anxiety disorder. METHOD Forty-one individuals with social anxiety disorder completed a videotaped speech. Anxiety ratings and degree of PEP were measured after the task as well as the day following the experiment. RESULTS Individuals in the distract group reported a greater decrease in anxiety from baseline to post-experimental task than those asked to focus. Individuals in the distract group also reported higher PEP about the task than those instructed to complete a focus task, which appeared to be partially accounted for by baseline differences in symptom severity and state anxiety. Degree of PEP was positively correlated with anxiety ratings, both after the experimental task as well as 24 hours later. CONCLUSIONS These findings suggest that naturalistic PEP is problematic for individuals with social anxiety disorder, especially for those with more severe symptoms. A distraction task, even with breakthrough PEP, appears to have useful short-term effects on anxiety reduction as compared to focus instructions.
The Influence of Corporate Social Responsibility Disclosure, Leverage, Sales Growth, and Industry Type on Profitability in Manufacturing Companies Listed at Indonesia Stock Exchange

This research aims to examine the influence of corporate social responsibility disclosure, leverage, sales growth, and industry type on firm’s profitability which was measured by return on asset (ROA). The population in this research are manufacturing companies listed in Indonesia Stock Exchange period 2013 quantitative research which the data are analyzed by using panel data regression method. The res research show that corporate social responsibility disclosure (CSRD), leverage, sales growth, and industry type have a positive and significant effect on return on asset (ROA). DOI: 10.32602/jafas.2019
Antioxidant Actions of Dried Flower Extracts of Hibiscus sabdariffa L. On Sodium Arsenite - Induced Oxidative Stress in Rats

2 Abstract: The antioxidant actions of 80% ethanolic extract of dried flowers of Hibiscus sabdariffa L. (HSE) on lipid peroxidation (LPO), reduced glutathione (GSH), glutathione-s-transferase (GST), catalase (CAT), superoxide dismutase (SOD) and vitamin C (VITC), were examined using a model of sodium arsenite (SA) - induced oxidative stress in rats. The oral administration of the extracts (200 and 300mg/kg body weight) significantly (P<0.05) decreased by 37% SA - induced malondialdehyde (MDA) formation in liver, suggesting the role of the extract in protection against pro-oxidant induced membrane damage. Pretreatment with the extracts prior to the intra-peritoneal administration of 10mg/kg body weight of SA reduced significantly (by 86%) and induced non-significantly (by 37%) the level of GSH depletion and GST activity respectively in a dose - dependent manner. The extract also attenuated SA - induced reduction in the serum level of VITC as evidenced by a significant (P<0.05) dose - dependent increase (by 60%) in serum VITC level. Pretreatment with the extracts showed a significant (P<0.05) increase in liver and decrease in whole blood activities of SOD (by 369% and 85%) and CAT (by 829% and 58%) respectively, hence revealing the hepatoprotective and antioxidant effectiveness of the extracts. Furthermore, the extracts, evaluated (in vitro) by their capacity of quenching 1, 1-diphenyl - 2-picrylhydraxyl (DPPH) free radical, showed strong scavenging effects on DPPH free radical at concentration of 0.20mg/ml (1C50 = 0.20mg/ml). The extracts at low and high concentrations showed no inhibitory effect on nitric oxide radical. These findings are suggestive of the possible chemopreventive and antioxidative role played by dried flower extract of Hibiscus sabdariffa L.
Evaluation des risques écotoxicologiques liés au déversement de Rejets Urbains par Temps de Pluie (RUTP) dans les cours d'eau : Application à une ville française et à une ville haïtienne

Les Rejets Urbains par Temps de Pluie (RUTP) contiennent des polluants sous forme soluble ou particulaires, issus du lessivage des bassins-versants qu'ils drainent. Ces rejets sont le plus souvent deverses dans les milieux recepteurs, en particulier les cours d'eau peri-urbains, sans traitement prealable. Il en resulte, dans certaines configurations, un risque de toxicite pour les ecosystemes des milieux concernes. Cette these propose deux demarches methodologiques pour evaluer les risques ecotoxicologiques (EDREcotox) lies a un tel scenario: une demarche a priori et une demarche a posteriori. La demarche a priori a ete developpee selon 3 approches complementaires de caracterisation des effets ecotoxicologiques: i) une «approche substances», ii) une «approche substances avec effets combines» et iii) une «approche matrice». Cette demarche a priori a ete par la suite appliquee a un scenario d'une ville francaise et a un scenario d'une ville haitienne. Pour une optimisation de la methodologie proposee dans le cadre de la demarche a priori, nous avons procede, dans un premier temps, a une etude de l'ecotoxicite et des effets combines des principaux polluants generalement presents dans les RUTP, vis-a-vis de Daphnia magna puis de Pseudokirchneriella subcapitata. En ce qui concerne l'«approche matrice», nous avons procede a une caracterisation ecotoxicologique d'echantillons de RUTP provenant des 2 sites etudies. La demarche a posteriori a ete developpee sur la base d'une comparaison entre un «etat amont» et un «etat aval», par rapport au point de deversement des RUTP dans la riviere du site francais, pour 3 horizons (eau de surface, zone benthique et zone hyporheique). L'application de ces 2 demarches methodologiques a conduit a des resultats coherents qui mettent en evidence un risque important pour les organismes du cours d'eau recepteur, avec une accentuation de ce risque pour les organismes des zones benthique et hyporheique. Au titre des perspectives, la poursuite du developpement de ces premieres methodologies pourra prendre en compte certains aspects additionnels comme la biodisponibilite des polluants, leur bioaccumulation, etc.
Early-Stage Alzheimer Disease Represents Increased Suicidal Risk in Relation to Later Stages

The level of risk for suicide in individuals with Alzheimer disease (AD) generally is considered to be low. It is important to recognize, however, that suicide can occur in early-stage Alzheimer disease on the background of a distinct high-risk profile. The objective of this report is to describe the clinical profiles of individuals with very mild Alzheimer disease who either attempted or completed suicide. We describe two participants in a longitudinal study of early-stage Alzheimer disease who were in the ninth decade of life and had very mild Alzheimer disease. Consistent with earlier cases reported in the literature, both displayed the following high-risk phenotype predisposing to suicidal risk: male gender, highly educated professional, preserved insight, dysthymic symptoms that did not meet criteria for major depression and postdated the onset of cognitive decline, and suicidal ideation. Neuropathological examination confirmed histologic Alzheimer disease in both cases. These cases, taken together, emphasize the need for awareness that early-stage Alzheimer disease may present a unique suicidal risk compared with later stages.