Miracle-dz/UniFAR-FTUs huggingface dataset:
Management of whiplash-associated disorder addressing thoracic and cervical spine impairments: a case report.

STUDY DESIGN Clinical case report. OBJECTIVES To describe a physical therapy program addressing impairments of the upper thoracic and cervical spine region for an individual with a whiplash-associated disorder. BACKGROUND A 32-year-old female with complaint of diffuse posterior cervical and upper thoracic region pain was evaluated 2 weeks following a motor vehicle accident. The patient reported that she was unable to sit for longer than 10 minutes or perform household duties for longer than 1 hour. In addition, she was unable to perform her tasks as a postal worker or participate in her customary running and aerobic exercise activities because of pain in the cervical and upper thoracic region. METHODS AND MEASURES An examination for physical impairments was performed, including the measurement of cervical range of motion using the CROM device, and the assessment of soft tissue and segmental mobility of the upper thoracic and cervical spine regions. The Northwick Park Neck Pain Questionnaire was used to assess functional limitations and disability. Manual therapy and therapeutic exercises were applied to address the identified impairments. Manual therapy techniques included soft tissue mobilization, joint mobilization, and joint manipulation. RESULTS The patient's cervical range of motion was improved and the disability score improved from 25% to 19.5% 3 days after the initial session addressing the thoracic spine. Following a second session also addressing thoracic spine impairments and the use of therapeutic exercises for 7 days, the disability score improved to 11.1%. At the final visit 17 days following the third visit, which focused on addressing the cervical spine impairments, there was complete resolution of signs and symptoms and disability. CONCLUSIONS Interventions addressing the impairments of the upper thoracic and cervical spine region were associated with reducing pain, increasing cervical range of motion, and facilitating return to work and physical activities in a patient with a whiplash-associated disorder. There is a need for continued research investigating the efficacy of providing interventions to the thoracic spine for patients with whiplash-related injuries.
Aberrant Folding of a Mutant Stat5b Causes Growth Hormone Insensitivity and Proteasomal Dysfunction*

A predicted alanine to proline substitution in Stat5b that results in profound short stature, growth hormone insensitivity, and immunodeficiency represents the first natural mutation of this transcription factor in a human. To understand the mechanisms responsible for these pathophysiological abnormalities, we have studied the biochemical and biophysical properties of the mutant Stat5b molecule. In a cellular reconstitution model growth hormone robustly stimulated tyrosine phosphorylation and transcriptional activity of wild-type Stat5b while Stat5bA630P was minimally modified and did not promote reporter gene expression. Steady state levels of Stat5bWT were ∼3-fold higher than Stat5bA630P in cell extracts prepared with nonionic detergents. Although initial rates of biosynthesis of both proteins were similar, pulse-chase experiments established that the apparent half-life of newly synthesized soluble Stat5bA630P was <15% of Stat5bWT (3.5 h versus >24 h). Stat5bA630P accumulated in cells primarily in cytoplasmic inclusion bodies. Structural analysis of the isolated SH2 domain containing the A630P mutation showed that it resembled the wild-type SH2 segment but that it exhibited reduced thermodynamic stability and slower folding kinetics, displayed an increased hydrophobic surface, and was prone to aggregation in solution. Our results are compatible with a model in which Stat5bA630P is an inactive transcription factor by virtue of its aberrant folding and diminished solubility triggered by a misfolded SH2 domain. The potential for aggregation and formation of cytoplasmic inclusions raises the possibility that Stat5bA630P could produce additional defects through inhibition of proteasome function.
Insect bite hypersensitivity in Belgian warmblood horses: prevalence and risk factors

Insect bite hypersensitivity (IBH) is an allergic reaction to the bites of certain Culicoides spp. or other insects. In this study, risk factors for IBH in Belgian warmblood horses stabled or grazing in Flanders (Belgium) were investigated. IBH records (n=3409) were collected in 2009 and 2011 using a questionnaire and face-to-face interviews. The classification of IBH-affected versus unaffected horses was based on the owner’s statement, and the reported IBH lifetime prevalence was 10%. Thirty eight percent of IBH affected horses had no clinical symptoms at the time of questioning. When only the presence or absence of clinical symptoms at the time of questioning was taken into account, the prevalence of IBH symptoms was 6.2%. Seventy percent of IBH-affected horses were treated with IBH measures to reduce clinical symptoms. Model selection was based on backwards elimination in a logistic regression framework starting with 17 factors. The age of the horse, vegetation of surrounding pasture and stud size were found to be significantly associated with the self-reported IBH status.
Modeling side-channel cache attacks on AES

In recent years, side-channel attacks have gained increasing attention, mainly due to their ability to extract sensitive information from their victims in an effortless way. Also, with the development and spread of cloud computing, where victims and potential attackers share physical infrastructure, these attacks are becoming a serious concern. For performance reasons, several resources as CPU cache memories have to be shared, leaving a door opened for attackers. However, when cryptographic processes are properly characterized it is possible to detect attacks which abuse one shared resource as, for example, CPU cache. In this paper we present a timing characterization of a process implementing a cryptographic algorithm such as AES. Then we characterize the same encryption process when suffering a cache attack and when sharing the CPU with other different processes to evaluate how they affect it and get accurate models. The main idea of this work is getting an accurate timing model to distinguish when a process is or not being attacked regarding to timing measurements. Once we get the model, we provide a detection algorithm that detects over 96% of attacks with false positive rates around 5%. The false positive rate is reduced to 0% when discarding the initial transitory state related to the booting stage of a new process.
Modified T-Flip-Flop based scan cell for RAS

Testing using a random access scan (RAS) design-for-test approach is experiencing renewed interest because of the potential for lower test application time, low power dissipation, and low test data volume compared to standard serial scan. In this paper we propose a significant modification and enhancement to the T-Flip-Flop based cell design for Random Access Scan(RAS) [1]. Importantly, the new RAS cell can allow the overlap of the test response read out with the loading of the next test input patterns within the same memory addressing cycle, thereby masking out the need for a separate memory cycle to read the test response in many cases. This can greatly reduce test application time. Experimental results show that the Modified T-Flip-Flop based scan cell is able to mask about 33% to 76% of reads. Further, this new RAS cell also eliminates the need for clock gating and additionally achieves reduction in gate overhead as much as about 20% compared to the existing T-flip-flop based RAS cell design.
Comparative effectiveness and safety of biological treatment options after tumour necrosis factor α inhibitor failure in rheumatoid arthritis: systematic review and indirect pairwise meta-analysis

Background Optimal treatment for rheumatoid arthritis (RA) after inadequate response (IR) to tumour necrosis factor α inhibitors (TNFi) remains uncertain. Objective To compare the efficacy and safety of biological agents after TNFi-IR. Methods A systematic literature search was carried out using Medline and Cochrane databases, as well as http://www.clinicaltrials. gov, and bibliographies of the retrieved literature were searched by hand. Randomised, placebo-controlled trials that enrolled patients with RA with TNFi-IR were included and American College of Rheumatology (ACR) response as primary efficacy outcome and adverse events (AEs), serious adverse events (SAEs) and serious infections (SIs) as safety measures were extracted. An indirect meta-analysis with pairwise comparisons of efficacy and safety data was then carried out using ORs or risk differences (RDs) in a random effects model. Results In four randomised controlled trials with 24 weeks' follow-up, direct comparisons of abatacept, golimumab, rituximab and tocilizumab versus placebo showed statistically significant mean ORs of 3.3–8.9 for ACR20, 5.5–10.2 for ACR50 and 4.1–13.5 for ACR70. Risks of AEs, SAEs and SIs versus placebo were non-significant. Indirect pairwise comparisons of the four biological agents showed no significant differences in ACR50 and ACR70. Golimumab had a significantly lower OR (0.56–0.59) for ACR20 but significantly fewer AEs (RD 0.13–0.18). Efficacy after one versus multiple TNFi failures did not differ significantly between the different biological agents. Conclusion In patients refractory to one or more TNFi, new biological agents provide significant improvement with good safety. Lacking head-to-head trials, indirect meta-analysis enables a comparison of effectiveness and safety of biological agents with each other and shows that all biological agents have similar effects.
Entrepreneurial CSR in the context of a regional family firm: A stakeholder analysis

The purpose of this paper is to contribute to the extant literature of family firms and corporate social responsibility (CSR), examining the case of West’n Fresh, a regional Western Australian family firm. Moreover, in adopting stakeholder theory (ST) the firm’s involvement in and resulting benefits from CSR are investigated. ,In-depth telephone and face-to-face interviews with three members of the firm, including one of its two owners, were further complemented through onsite observations and secondary data from the firm’s website and media reports. ,Entrepreneurial CSR emerges as a critical element in the family firm’s business philosophy, whereby through innovative practices the ownership is able to create a balance between the firm’s financial objectives and socially responsible initiatives. In particular, the development of food products creates business opportunities while at the same time addresses the needs of different consumer groups, in particular, aged care individuals. These findings have alignments with the four theses of ST; for instance, the recognition of various stakeholder groups by the firm’s ownership, and the initiatives to improve their quality of life clearly suggest associations with normative thesis. ,Although the field of family entrepreneurship has grown significantly, many under-researched aspects of this discipline remain. For instance, family business research, including on CSR conducted in Western Australia, a state with a very strong economic significance, and with multiple links to the outside world is very limited.
Cancer screening among jail inmates: frequency, knowledge, and willingness.

OBJECTIVES We determined jail inmates' knowledge of cancer screening tests, their frequency of screening, and their willingness to undergo screening in jail in order to assess preventive health services for jail inmates. METHODS We performed a cross-sectional interview survey of random samples of county jail inmates (n=133). RESULTS Approximately half (53%) the participants were African American, 17% were White, 11% were Latino, and 9% reported multiple ethnicities. Among women aged 18 years and older, 90% had had a Papanicolaou (Pap) test within 3 years, and 94% were willing to be screened in jail. Having ever had a Pap test while incarcerated was significantly associated with being up to date on cervical cancer screening. For women aged 40 years and older, 41% reported having had a mammogram within 2 years, and 88% were willing to have one. Among men (n=51) and women (n=4) aged 50 years and older, 25% had knowledge of colon cancer screening, 31% were up to date, and 69% were willing to be screened. Increased knowledge about colon cancer screening was significantly associated with being White and having insurance. Jail inmates, particularly African Americans, had significantly lower frequency of sigmoidoscopy and colonoscopy than the general population. CONCLUSIONS Jail could be an appropriate venue in which to provide cancer screening for a high-risk population. Inmates were receptive to jail-based screening.
THE WORLD OF AGRITOURISTS: A PSYCHOLOGICAL PERSPECTIVE

An ethnographic study conducted in order to investigate agritourist satisfaction in the Mediterranean Island of Cyprus brings to the surface novel information in regards to motivation; the formation of expectations; satisfaction achievement; and behavioural intentions, of agritourists. The findings of the study contribute to the existing body of knowledge in the field of tourism by divulging further details regarding the relatively unexplored niche market of agritourists. Further to this and perhaps more importantly, the fieldwork findings assist destinations and practitioners alike to achieve guest satisfaction and foster the positive future behavioural intentions of their guests.
Collective action problems in the contracting of public services

In this paper, we examine collective action problems in the UK government in the process of contracting public services to the private sector. In particular, we examine the Ministry of Justice (MoJ) and its evolution in contract monitoring as part of a larger effort of the government to join up departments in contract management. By analyzing MoJ’s management of the electronic tagging contract with G4S and Serco, we show that a lack of coordination within the department and with other departments was a major reason for the overbilling by the two companies. Recent efforts to join up contract management efforts throughout government show promise in rectifying these contracting issues.
A “Suicide Pill” For Older People: Attitudes of Physicians, the General Population, and Relatives of Patients who died After Euthanasia or Physician-Assisted Suicide in The Netherlands

ABSTRACT In the Netherlands there has been ongoing debate in the past 10 years about the availability of a hypothetical “suicide pill”, with which older people could end their life in a dignified way if they so wished. Data on attitudes to the suicide pill were collected in the Netherlands from 410 physicians, 1,379 members of the general population, and 87 relatives of patients who died after euthanasia or physician-assisted suicide. The general population and relatives were more in favor than physicians. Fifteen percent of the general population and 36% of the relatives thought a suicide pill should be made available.
Geohelminths Contamination of Fruits and Vegetables Sold in Lafia Markets

Fruits and vegetables are important in human diets as they help the body system function optimally but could also pose risk to human health when taken unhygienically. This study assessed geohelminths contamination Hookworm, Strongyloides stercoralis and Trichuiris trichiura with A. lumbricoides occurring highest. Information obtained indicated that 65% of the respondents have never heard of geohelminth parasites. Effective health and hygiene education is necessary in order to overcome the continued spread of geohelminths infections through eating unhygienic fruits and vegetables.
Does Smoking Intervention Influence Adolescent Substance Use Disorder Treatment Outcomes?

Although tobacco use is reported by the majority of substance use disordered (SUD) youth, little work has examined tobacco focused interventions with this population. The present study is an initial investigation of the effect of a tobacco use intervention on adolescent SUD treatment outcomes. Participants were adolescents in SUD treatment taking part in a cigarette smoking intervention efficacy study, assessed at baseline and followed up at 3- and 6-months post-intervention. Analyses compared treatment and control groups on days using alcohol and drugs and proportion abstinent from substance use at follow up assessments. Adolescents in the treatment condition reported significantly fewer days of substance use and were somewhat more likely to be abstinent at 3-month follow up. These findings suggest that tobacco focused intervention may enhance SUD treatment outcome. The present study provides further evidence for the value of addressing tobacco use in the context of treatment for adolescent SUD's.
Internet-based treatment after pregnancy loss: concept and case study

The loss of a child during pregnancy results in significant psychological stress for many women, and may lead to long-lasting grief and psychological illnesses. However, only a small percentage of those affected seek or receive traditional forms of psychological treatment, and therefore novel treatment approaches and methods are required. This article introduces an Internet-based psychotherapy programme for patients after pregnancy loss. The five-week intervention comprises two components: structured writing disclosure and cognitive-behavioural therapy. Communication between the therapist and patient is text-based and asynchronous. The writing protocol consists of three treatment phases: self-confrontation, cognitive reappraisal and social sharing. A case report is presented to illustrate the course of the treatment and clinical considerations associated with delivering Internet-based interventions to patients after pregnancy loss.
Two-Stage Stochastic Model Using Benders’ Decomposition for Large-Scale Energy Resource Management in Smart Grids

The ever-increasing penetration level of renewable energy and electric vehicles threatens the operation of the power grid. Dealing with uncertainty in smart grids is critical in order to mitigate possible issues. This paper proposes a two-stage stochastic model for a large-scale energy resource scheduling problem of aggregators in a smart grid. The idea is to address the challenges brought by the variability of demand, renewable energy, electric vehicles, and market price variations while minimizing the total operation cost. Benders’ decomposition approach is implemented to improve the tractability of the original model and its computational burden. A realistic case study is presented using a real distribution network in Portugal with high penetration of renewable energy and electric vehicles. The results show the effectiveness of the proposed approach when compared with a deterministic model. They also reveal that demand response and storage systems can mitigate the uncertainty.
Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle‐aged men: a meta‐analysis

Objectives Ageing in men is associated with a gradual decline in serum testosterone levels and a concomitant loss of muscle mass, accumulation of central adiposity, impaired mobility and increased risk of bone fractures. Whether androgen treatment might be beneficial in these subjects is still under debate. We have carried out a systematic review of randomized controlled trials (RCTs) evaluating the effects of testosterone (T) administration to middle‐aged and ageing men on body composition, muscle strength, bone density, markers of bone metabolism and serum lipid profile.
The Influence of Market Activities and Underwriter Reputation Towards the Excess Returns in the IPO Underwriting Process in Indonesian Capital Market

This study provides a more comprehensive analysis of an IPO (Initial Public Offering) underwriting process. It considers the set of actions that an underwriter undertakes as an integrated process, explicitly recognizing the interdependencies among pre-market, issue-date, and aftermarket underwriter activities. It can be drawn only if these relationships are fully rather than partially considered. This analysis clarifies the relationships between the various underwriter activities and the returns that investors earn during different periods after the offerings. It also shows that an underwriter reputation has implications for both underwriter activities during the underwriting process and investor returns.Underwriter reputation is a positive but weakly determinant of pre-market underwriter activities, unrelated to aftermarket price stabilization activities, and unrelated to investor returns. Pre-market underwriter activities are a significant determinant of initial returns but unrelated to aftermarket activities and short-run returns. Initial returns are significantly related to aftermarket underwriter activities and longer-run returns. The results suggest for a simultaneous consideration of underwriter reputation and market activities, and for which path analysis can be drawn about the IPO as a set of process and investor returns.
The Differential Promotion Effectiveness on Hedonic Versus Utilitarian Products

Consumers find it more difficult to justify hedonic than utilitarian consumptions. Consequently, we propose that promotions have a stronger effect on the purchase likelihood of hedonic than utilitarian products. As expected, the results of a series of studies demonstrate very strong differential impacts of promotions on the purchase likelihood of hedonic vs. utilitarian products. Further, although promotions are particularly effective in stimulating purchases of hedonic products, this effect is eliminated when the hedonic product is intended as a gift for others or when consumers already have justifications. Implications of the findings are discussed.
Corporate Entrepreneurship Top Managers And New Business Creation

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Prevalence and types of tooth resorption in dogs with oral tumors.

OBJECTIVE To determine the prevalence and types of tooth resorption in dogs with oral tumors and to compare findings with those for control dogs. ANIMALS 101 dogs with oral tumors and 128 control dogs that did not have oral tumors and for which dental radiographs were available. PROCEDURES Exclusion criteria for dogs included systemic disease, long-term administration of anti-inflammatory drugs, traumatic occlusion, severe semigeneralized or generalized periodontitis, and endodontic disease. For each dog with an oral tumor, histologic sections of biopsy specimens of tumors were examined. Dental radiographic images of dogs were examined, and the presence and type of tooth resorption were determined for each tooth. Statistical analyses were performed to compare data regarding prevalence of tooth resorption. RESULTS Teeth at tumor sites in dogs with nonodontogenic tumors were significantly more frequently affected with external inflammatory resorption, compared with teeth at tumor sites in dogs with odontogenic tumors. Teeth at sites distant from tumors in dogs with oral tumors were 3.2 times as likely to have external surface resorption (OR, 3.2; 95% confidence interval, 1.3 to 7.9) and 83.4 times as likely to have external inflammatory resorption (OR, 83.4; 95% confidence interval, 9.7 to 719.6) as teeth in control dogs. CONCLUSIONS AND CLINICAL RELEVANCE Resorption of teeth at tumor sites and at sites distant from tumors was common in dogs with oral tumors. Results of the present study will contribute to an understanding of the complex effects of oral tumors on local and distant hard tissues.