Miracle-dz/UniFAR-FTUs huggingface dataset:
Tweetocracy Switzerland: exploring the representativeness, structuration and content of swiss party politics on twitter

This contribution puts forward an explorative account of the Swiss political parties' presence on Twitter. Social media in general, and the Twitter microblogging service more in particular, have recently received a lot of attention by scholars who try to harvest the new data source for the social sciences. However, the validity of these data sources is heavily disputed. Therefore, this contribution takes one step back and tries to establish the usefulness of political communication on Twitter for the political sciences in Switzerland, a context which is not well studied so far. More precisely, this study serves two main purposes. First, a descriptive overview over the geographical distribution, network structure and basic dynamic trends of Swiss Twitter accounts which are related to one of the political parties in Switzerland is presented. Subsequently, social network and text analyses are applied to provide evidence on the following questions. In terms of its representativeness, it can be shown that the Swiss partisan Twitter sphere is systematically biases towards the political left and urban areas. As for the structuration of the Twitter sphere, it is revealed that users are separated into a handful of highly networked actors and many peripheral ones. Furthermore, there are clear signs of political homophily among users of the same party. In terms of the Tweets communicated, left and small center parties show a more conversational style than right parties.
Staffing Benchmarks for Clinical Laboratories

s and case studies are now being accepted for the College of American Pathologists (CAP) 2012 meeting, which will be held September 9th through the 12th in San Diego, California. Submissions for the CAP ’12 Abstract Program will be accepted through Monday, April 2, 2012. Accepted submissions will appear in the September 2012 issue of the Archives of Pathology & Laboratory Medicine. Visit the CAP ’12 website at www.cap. org/cap12 for a link to the submission site and additional abstract program information as it becomes available. Arch Pathol Lab Med—Vol 136, February 2012 Staffing Benchmarks for Clinical Laboratories—Jones et al 147
On Academic Discourse.

in a writing course. Teachers who write continually? who love, and participate in, academic discourse ? embody the values they seek to teach, and they remind themselves just how difficult such writing is, how dif ficult learning itself is. To recognize learning as diffi cult and problematic is the beginning of wisdom. Academic discourse aims at defining fields of study, defining the evidence for the study, and establishing connections between parts of the evidence. It aims, too, at systematic exposition. As Aristotle taught long ago and as the rabbis who taught the Torah and the Talmud also believed and as the medieval Scholastics and the humanists of the Renaissance assumed, sys tematic exposition is defined by the law of noncon tradiction. Nothing can be true and not true at the same time. However we may introduce our work or select the evidence to support our thinking, the fun damental aim of academic discourse is to report, ex plain, and argue in such a way that we communicate to readers something they can believe, something they will want to believe. We know, alas, that contradictions abound and that it lies beyond our power to resolve them whenever we please, that in fact sometimes we can only point them out and suggest resolutions. The essence of Hegel's di alectic, according to Walter Kaufmann, is that any sys tem of thought extended far enough begins to contradict itself (154-56). That is the point of an extraordinary essay called "Teaching 'Shakespeare,'" by my former colleague Robert N. Watson, a personal reflection on the contradictions that arise between what we know of modern criticism and what we teach in our classrooms. Academic writers cluster around the contradictions like iron fil ings in a magnetic field. We know, in short, that in every . branch of knowledge some hard, implacable, irreducible frag ments of evidence resist our ef
Translocation of wild populations: conservation implications for the genetic diversity of the black‐lipped pearl oyster Pinctada margaritifera

Translocation has been widely studied as a tool for conservation management to restore or enhance degraded populations. On the contrary, few studies have been conducted on translocation for commercial purposes. In this study, we evaluate the genetic consequences of translocation of wild individuals of Pinctada margaritifera on farmed and adjacent wild populations. We tested the hypotheses that translocations would induce high genetic heterogeneity in farmed populations and this heterogeneity would then leak into the adjacent wild populations. In fact, farmed samples exhibit high levels of heterogeneity and low pairwise relatedness compared to wild populations, highlighting the pooling of genetically divergent populations into farms. We also demonstrate that this heterogeneity is transmitted to adjacent wild populations as a result of interbreeding. Adjacent wild populations tend to have higher genetic diversity values and greater pairwise relatedness coefficient with farmed populations than wild populations. Overall, pearl culture in French Polynesia promotes the mixing of unrelated individuals in farmed locations and reduces genetic divergence among geographically distant populations as well as among farmed and wild populations of a same lagoon. We also studied for the first time a farmed population originating from spat collected in a lagoon where release of hatchery‐produced larvae occurred 10 years ago and we were able to identify four distinct genetic groups. These groups contribute highly to reproduction and caused considerable genetic drift in the lagoon, suggesting that hatchery‐produced larvae are neither sustainable method for pearl culture nor for conserving the diversity of P. margaritifera in French Polynesia.
Persuading End Users to Act Cautiously Online: Initial Findings of a Fear Appeals Study on Phishing

This study examined the impact of fear appeals on user cognitions and behavioural intentions with regard to minimizing the threat of phishing attacks. 1,201 Internet users filled out an online survey and were presented with one of three fear appeal conditions: strong fear appeal, weak fear appeal and no fear appeal. Arguments regarding perceived vulnerability of phishing attacks and arguments concerning response efficacy of vigilant online information-sharing behaviour were manipulated in the fear appeals. Analysis of variance showed that the strong fear appeal message elevated threat appraisal, coping appraisal and protection motivation. Partial least squares path modelling showed little variation between the three groups concerning explained variance of protection motivation and fear. Nonetheless, we conclude that precautionary online behavioural intentions can be raised by making Internet users aware of the threat while simultaneously providing behavioural advice on how to mitigate this threat.
Coaching patients to self-care: a primary responsibility of nursing.

Aim. To explore the process nurses use to guide and support patients to actively re-establish self-care. Background. The movement of hospitalized patients from less to more independence is primarily a nursing responsibility. Studies of nursing practice in inpatient rehabilitation settings have begun to shed some light on this, but as yet there is limited understanding of the actual skills nurses use to support patients to re-establish self-care. Method. This study used grounded theory. Microanalysis and constant comparative analysis of data collected during interviews with, and observation of, registered and enrolled nurses during everyday nursing practice in five inpatient rehabilitation units facilitated open, axial and selective coding. Relevant literature was woven into the final theory. Findings. To facilitate patient transition from the role of acute care patient to rehabilitation patient actively reclaiming self-care, nurses engaged in a three-phase process known as coaching patients to self-care. The three phases were: easing patients into rehabilitation, maximizing patient effort and providing graduated assistance. Conclusion. Coaching patients to self-care is a primary activity and technology of rehabilitation nursing. Relevance to clinical practice. Patients in a variety of settings would benefit from nurses incorporating coaching skills into their nurse-patient interactions.
Group A Streptococcus causing a life‐threatening postpartum necrotizing myometritis: A case report

During childbirth, group A Streptococcus (GAS) can cause a diverse spectrum of disorders ranging from asymptomatic infection to puerperal sepsis and toxic shock syndrome. We report on a healthy parturient who survived a life‐threatening necrotizing myometritis due to GAS following an unremarkable spontaneous delivery. Approximately 29 h after an unremarkable spontaneous vaginal delivery, a generally healthy 28‐year‐old multiparous woman developed a life‐threatening necrotizing myometritis due to GAS. The patient subsequently underwent a total abdominal hysterectomy. Following the surgery, she made a prompt and complete recovery. The course of this extremely rare complication might be so fulminant that the diagnosis is sometimes made after the patient cannot be saved. Clinicians should still consider GAS in life‐threatening infections occurring during the perinatal period.
Psychological functioning of people living with chronic pain: a meta-analytic review.

OBJECTIVES Chronic pain (CP; >3 months) is a common condition that is associated with significant psychological problems. Many people with CP do not fit into discrete diagnostic categories, limiting the applicability of research that is specific to a particular pain diagnosis. This meta-analysis synthesized the large extant literature from a general CP, rather than diagnosis-specific, perspective to systematically identify and compare the psychological problems most commonly associated with CP. METHODS Four databases were searched from inception to December 2013 (PsychINFO, The Cochrane Library, Scopus, and PubMed) for studies comparing the psychological functioning of adults with CP to healthy controls. Data from 110 studies were meta-analysed and Cohen's d effect sizes calculated. RESULTS The CP group reported experiencing significant problems in a range of psychological domains (depression, anxiety, somatization, anger/hostility, self-efficacy, self-esteem and general emotional functioning), with the largest effects observed for pain anxiety/concern and somatization; followed by anxiety and self-efficacy; and then depression, anger/hostility, self-esteem and general emotional functioning. CONCLUSIONS This study demonstrates, for the first time, that individuals with CP are more likely to experience physically focussed psychological problems than other psychological problems and that, unlike self-efficacy, fear of pain is intrinsically tied to the CP experience. This challenges the prevailing view that, for individuals with CP, problems with depression are either equal to, or greater than, problems with anxiety, thereby providing important information to guide therapeutic targets. PRACTITIONER POINTS Positive clinical implications: This is the first time that the CP literature has been synthesized from a general perspective to examine psychological functioning in the presence of CP and provide practical recommendations for assessment and therapy. Individuals with CP were most likely to experience psychological problems in physically focussed areas - namely pain anxiety/concern and somatization. Although fear of pain was intrinsically tied to the CP experience, self-efficacy was not. CP was more strongly associated with anxiety than with depression. Limitations The study focuses on the general CP literature, adults and research-utilizing self-report measures. Meta-analyses are limited by the empirical literature on which they are based.
Revising TAM for hedonic location-based social networks: the influence of TAM, perceived enjoyment, innovativeness and extraversion

As a hedonic information system, a location-based social network LBSN is often seen as a promising innovative mobile service. However, research on LBSNs is still limited. Little is known about the factors influencing the intention to use LBSNs. Our study aims to explain the critical factors underlying the use of an LBSN, by developing a conceptual framework based on the technology acceptance model, the theory of diffusion of innovations and the five-factor model. To examine our proposed research model, we conducted an online survey among users of a Dutch LBSN. Our results demonstrate that perceived usefulness, perceived ease of use, perceived enjoyment and innovativeness predict the intention to use and the actual use of LBSNs, and hedonic information systems in general. We found no effect of extraversion. Our results suggest that developers of LBSNs should especially aim at pleasance and fun.
SHP-1- and Phosphotyrosine-Independent Inhibitory Signaling by a Killer Cell Ig-Like Receptor Cytoplasmic Domain in Human NK Cells1

Killer cell Ig-like receptors (KIR) are MHC class I-binding immunoreceptors that can suppress activation of human NK cells through recruitment of the Src homology 2-containing protein tyrosine phosphatase-1 (SHP-1) to two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in their cytoplasmic domains. KIR2DL4 (2DL4; CD158d) is a structurally distinct member of the KIR family, which is expressed on most, if not all, human NK cells. 2DL4 contains only one ITIM in its cytoplasmic domain and an arginine in its transmembrane region, suggesting both inhibitory and activating functions. While 2DL4 can activate IFN-γ production, dependent upon the transmembrane arginine, the function of the single ITIM of 2DL4 remains unknown. In this study, tandem ITIMs of KIR3DL1 (3DL1) and the single ITIM of 2DL4 were directly compared in functional and biochemical assays. Using a retroviral transduction method, we show in human NK cell lines that 1) the single ITIM of 2DL4 efficiently inhibits natural cytotoxicity responses; 2) the phosphorylated single ITIM recruits SHP-2 protein tyrosine phosphatase, but not SHP-1 in NK cells; 3) expression of dominant-negative SHP-1 does not block the ability of 2DL4 to inhibit natural cytotoxicity; 4) surprisingly, mutation of the tyrosine within the single ITIM does not completely abolish inhibitory function; and 5) this correlates with weak SHP-2 binding to the mutant ITIM of 2DL4 in NK cells and a corresponding nonphosphorylated ITIM peptide in vitro. These results reveal new aspects of the KIR-inhibitory pathway in human NK cells, which are SHP-1 and phosphotyrosine independent.
Circulatory and respiratory changes in response to muscular exercise in man

INTRODUCTION. IT is well known that if muscular exercise is undertaken at a steady rate of working, some appreciable time elapses before the resultant increases in circulation and respiration attain an approximate equilibrium corresponding to the rise in metabolism. It would seem, therefore, not unlikely that the early stages of muscular work must be performed at a considerable disadvantage owing to this lag in the responses of both systems, even though the ultimate level attained by the circulation and respiration is sufficient to allow the work to be maintained at a steady rate almost indefinitely. Thus, for example, the initial accumulation of lactic acid in the body might be considerably influenced by the rapidity with which the circulation and respiration respond to the muscular exertion, and if so, it ought to be possible to obtain evidence of this effect either during or after a short period of steady effort. Recently Jervell() has found that the lactic acid content of the venous blood in man rises most rapidly in the first few minutes of steady work, and suggests that this is largely due to the fact that the circulation rate is less at the start of exercise than later on. With a view to testing this hypothesis, a number of pairs of experiments were performed. In each of these pairs the maximum rate of, work was identical, but in the one case the subject started from rest with the maximum load, while in the other case the load was increased in several small increments to maximum, with the idea that the accommodation of circulation and respiration would be approaching completion by the time the maximum load was actually applied. Indirect evidence of the relative extents to which lactic acid accumulated was sought by following the course of the total respiratory exchange during preliminary rest and subsequent work, in some experiments; and the changes in the alveolar carbon dioxide percentage after stopping work,
A Chance-Constrained Two-Stage Stochastic Program for Unit Commitment With Uncertain Wind Power Output

In this paper, we present a unit commitment problem with uncertain wind power output. The problem is formulated as a chance-constrained two-stage (CCTS) stochastic program. Our model ensures that, with high probability, a large portion of the wind power output at each operating hour will be utilized. The proposed model includes both the two-stage stochastic program and the chance-constrained stochastic program features. These types of problems are challenging and have never been studied together before, even though the algorithms for the two-stage stochastic program and the chance-constrained stochastic program have been recently developed separately. In this paper, a combined sample average approximation (SAA) algorithm is developed to solve the model effectively. The convergence property and the solution validation process of our proposed combined SAA algorithm is discussed and presented in the paper. Finally, computational results indicate that increasing the utilization of wind power output might increase the total power generation cost, and our experiments also verify that the proposed algorithm can solve large-scale power grid optimization problems.
A Fiber-Modified Mesothelin Promoter–Based Conditionally Replicating Adenovirus for Treatment of Ovarian Cancer

Purpose: Recently, virotherapy has been proposed as a new therapeutic approach for ovarian cancer. Conditionally replicative adenoviruses (CRAd) may contain tumor-specific promoters that restrict virus replication to cancer cells. Mesothelin, a cell surface glycoprotein, is overexpressed in ovarian cancer but not in normal ovarian tissues. The purpose of this study was to explore the therapeutic utility of a mesothelin promoter–based CRAd in a murine model of ovarian cancer, using noninvasive in vivo imaging. Experimental Design: We constructed a mesothelin promoter–based CRAd with a chimeric Ad5/3 fiber (AdMSLNCRAd5/3) that contains an Ad5 tail, Ad5 shaft, and an Ad3 knob. Previously, a chimeric Ad5/3 fiber has shown improved infectivity in many ovarian cancer cells. Viral replication and oncolysis were assessed in a panel of ovarian cancer cell lines. To test the oncolytic efficacy of AdMSLNCRAd5/3 in a murine model, bioluminescence imaging of tumor luciferase activity and survival analysis were done. Results: AdMSLNCRAd5/3 achieved up to a 10,000-fold higher cell killing effect and up to 120-fold higher levels of viral replication in all human ovarian cancer cells, compared with wild-type Ad5. AdMSLNCRAd5/3 significantly inhibited tumor growth as confirmed by in vivo imaging (P < 0.05). Survival with AdMSLNCRAd5/3 was significantly enhanced when compared with no virus or with a wild-type Ad5-treated group (P < 0.05). Conclusions: The robust replication, oncolysis, and in vivo therapeutic efficacy of AdMSLNCRAd5/3 showed that this CRAd is a promising candidate for treating ovarian cancer. Importantly, we have applied in vivo imaging that has allowed repeated and longitudinal measurements of tumor growth after CRAd treatment.
Importance of Brand Awareness and Brand Loyalty in assessing Purchase Intentions of Consumer

The aim of this endeavor is to identify the effect of brand awareness and brand loyalty on purchase intention. Questionnaires were distributed to collect the responses from the employees in services sectors and conveniently available general public while descriptive statistics and regression analysis were used to analyze the data and draw the conclusions. Brand Awareness and brand loyalty have strong positive association with purchase intention. Managers all over the world should strive to promote the brand awareness along with brand loyalty as both of them contribute towards positive purchase intentions.
Total Parenteral Nutrition Is a Major Risk Factor for Central Venous Catheter-Related Bloodstream Infection in Colorectal Cancer Patients Receiving Postoperative Chemotherapy

Purpose: To clarify the risk factors for central venous catheter-related bloodstream infection (CVCR-BSI) in patients receiving chemotherapy after surgery for colorectal cancer (CRC). Methods: CVCR-BSI was evaluated retrospectively from a database of patients who had received postoperative chemotherapy using central venous catheters (CVC). Results: One hundred and nine patients received 542 CVC for a total of 5,558 catheter-days. There were no significant differences in background between the patients who had CVCR-BSI and those who did not, except for the administration of total parenteral nutrition (TPN) (p < 0.0001). Moreover, univariate analyses (using factors including type of catheter, sex, age, troubles with insertion, kinds of disinfectant, kinds of catheter, length of inserted catheter, term of catheter insertion and administration of TPN) revealed that the administration of TPN (odds ratio, 12.74; 95% CI, 2.489–62.26; p = 0.0023) was the only risk factor for CVCR-BSI. Conclusions: TPN is a major risk factor for CVCR-BSI in CRC patients receiving postoperative chemotherapy.
Beyond top‐down and bottom‐up work redesign: Customizing job content through idiosyncratic deals

Two established approaches to work redesign are formal top-down interventions and proactive bottom-up job crafting. Top-down approaches are limited in their ability to create individually optimized work characteristics, whereas bottom-up processes are constrained by the latitude workers have to modify their own jobs. Following recent research on the idiosyncratic deals (i-deals) individuals negotiate with their employer, task i-deals customizing job content are suggested as a third approach to work redesign. Hypotheses on antecedents and consequences of task i-deals were tested in two studies conducted in the United States and Germany using structural equation modeling. LMX related positively to the extent of successfully negotiated task i-deals, which, in turn, was associated with a more positive evaluation of work characteristics—specifically, higher complexity and control and lower stressors. Work characteristics mediated positive indirect effects of task i-deals on employee initiative and work engagement. Denied requests for task i-deals were associated with a more negative assessment of work characteristics. We conclude with theoretical, practical, and research implications for better understanding and implementing work redesign through i-deals. Copyright © 2010 John Wiley & Sons, Ltd.