Miracle-dz/UniFAR-FTUs huggingface dataset:
Percutaneous Left Main Coronary Intervention: A Review of Plaque Modification in Left Main Percutaneous Coronary Intervention

Left main coronary artery (LMCA) stenosis has long been recognized as a marker of increased morbidity and mortality. Current treatment algorithms for LMCA stenosis consider both percutaneous coronary intervention (PCI) with drug eluting stents (DES) and coronary bypass surgery, each with advantages based on individual patient characteristics. Since the LMCA is the largest artery in the coronary tree, plaque volume and calcification is greater than other coronary segments and often extends to the distal bifurcation segment. In LMCA bifurcation lesions, larger minimal stent area is strongly associated with better outcome in the DES era. Plaque modification strategies such as rotational, orbital, or laser atherectomy are effective mechanisms to reduce plaque volume and alter compliance, facilitating stent delivery and stent expansion. We present a case of a calcified, medina class 1,1,1 LMCA lesion where intravascular ultrasound (IVUS) and orbital atherectomy were employed for optimal results. In this context, we review the evidence of plaque modification devices and the rationale for their use in unprotected left main PCI.
Are They Buying It? United States Consumers’ Changing Attitudes toward More Humanely Raised Meat, Eggs, and Dairy

Simple Summary The lack of a consistent approval process for animal welfare claims in the US has allowed for misleading labeling of meat, eggs, and dairy. Products that do have meaningful welfare certifications tend to be more expensive. We administered a survey to determine consumers’ attitudes towards welfare certifications and the willingness to pay for foods from animals raised under more humane conditions. Most respondents (78%) thought it was important to know that animal-welfare assessments are conducted by an independent third party or the federal government (and not only the industry producer). The majority of respondents would be willing to pay extra for foods with a trustworthy welfare certification both in supermarkets and in restaurants. Our findings underscore the importance of eliminating fraudulent or misleading claims that can erode consumer trust and suggest that retailers can best serve consumers who are interested in higher welfare products by stocking products with certifications that convey meaningful information on the animal welfare standards from the source farms. Abstract This survey research sampled 1000 US (United States) consumers of meat, eggs, and dairy on their attitudes towards the welfare of farm animals and the willingness to pay for products with trustworthy welfare certifications. Most respondents (70%) reported paying attention to labels that indicate how the animals were raised and 78% believed there should be an objective third party to ensure farm animal welfare. The weighted average of the marginal willingness to pay for products raised under a trustworthy welfare certification was $0.79 for eggs (a 32% premium) and $0.96 for 1 lb. of chicken breast (a 48% premium). In addition, 57% of respondents reported they would be likely to choose a restaurant because it serves welfare-certified animal products and are also willing to pay ≥$5.00 extra per entrée. These findings suggest that many US consumers, particularly millennials, would be willing to seek out higher welfare products if they trust the label claims.
Growth at Elevated CO2 Requires Acclimation of the Respiratory Chain to Support Photosynthesis1[OPEN]

Mitochondrial alternative oxidase respiration supports source leaf carbon and energy balance during growth at elevated CO2. Plants will experience an elevated atmospheric concentration of CO2 (ECO2) in the future. Growth of tobacco (Nicotiana tabacum) at ECO2 more than doubled the leaf protein amount of alternative oxidase (AOX), a non-energy-conserving component of mitochondrial respiration. To test the functional significance of this AOX increase, wild-type tobacco was compared with AOX knockdown and overexpression lines, following growth at ambient CO2 or ECO2. The ECO2-grown AOX knockdowns had a reduced capacity for triose phosphate use (TPU) during photosynthesis compared with the other plant lines. This TPU limitation of CO2 assimilation was associated with an increased accumulation of glucose-6-phosphate, sucrose, and starch in the leaves of the knockdowns. Under TPU-limiting conditions, the size of the proton gradient and proton motive force across the thylakoid membrane was enhanced in the knockdowns relative to the other plant lines, suggesting a restriction of chloroplast ATP synthase activity. This restriction was not due to a decline in ATP synthase (AtpB) protein amount. The knockdowns also displayed a photosystem stoichiometry adjustment at ECO2, which was absent in the other plant lines. Additional experiments showed that the way in which AOX supports photosynthesis at ECO2 is distinct from its previously described role in supporting photosynthesis during water deficit. The results are discussed in terms of how AOX contributes to TPU capacity and the maintenance of chloroplast ATP synthase activity at ECO2. Overall, the evidence suggests that AOX respiration is needed to maintain both the carbon and energy balance in photosynthetic tissues during growth at ECO2.
Cannabinoid CB2 Receptor Gene and Environmental Interaction in the Development of Psychiatric Disorders

CB2 cannabinoid receptor (CB2R) gene is associated with depression. We investigated the gene-environment interaction between CB2R function and diverse stressors. First, anxiety-like behavior during chronic-mild-stress (CMS) was evaluated in C57BL/6JJmsSlc mice following treatment with CB2R agonist JWH015 or inverse-agonist AM630. Second, locomotor activity and anxiety-like behavior were measured following exposure to an immune poly I:C stressor. Gene expressions of HPA axis related molecules, Fkbp5, Nr3c1 and Crf and pro-inflammatory cytokine Il-1b, as well as Bdnf as a key neurotrophin that supports neuron health, function, and synaptic plasticity, were determined in hippocampus of Cnr2 knockout mice, as indicators of stressful environment. CMS-induced anxiety-like behavior was enhanced by AM630 and reduced by JWH015 and fluvoxamine. Poly I:C reduced locomotor activity and increased anxiety-like behavior, and these effects were pronounced in the heterozygote than in the wild type mice. Fkbp5 and Nr3c1 expression were lower in the Cnr2 heterozygotes than in the wild type mice with Poly I:C treatment. These findings indicate that interaction between CB2R gene and stressors increases the risk of depression-like behaviors that may be linked with neuro-immune crosstalk. Further studies in human subjects are necessary to determine the role of CB2R and environmental interaction in the development of depression.
A 3D Relative-Motion Context Constraint-Based MAP Solution for Multiple-Object Tracking Problems

Multi-object tracking (MOT), especially by using a moving monocular camera, is a very challenging task in the field of visual object tracking. To tackle this problem, the traditional tracking-by-detection-based method is heavily dependent on detection results. Occlusion and mis-detections will often lead to tracklets or drifting. In this paper, the tasks of MOT and camera motion estimation are formulated as finding a maximum a posteriori (MAP) solution of joint probability and synchronously solved in a unified framework. To improve performance, we incorporate the three-dimensional (3D) relative-motion model into a sequential Bayesian framework to track multiple objects and the camera’s ego-motion estimation. A 3D relative-motion model that describes spatial relations among objects is exploited for predicting object states robustly and recovering objects when occlusion and mis-detections occur. Reversible jump Markov chain Monte Carlo (RJMCMC) particle filtering is applied to solve the posteriori estimation problem. Both quantitative and qualitative experiments with benchmark datasets and video collected on campus were conducted, which confirms that the proposed method is outperformed in many evaluation metrics.
Oxygen consumption, rate of perceived exertion and enjoyment in high-intensity interval eccentric cycling

Abstract The objectives of this article are to compare oxygen consumption (VO2) and perceptual responses between continuous and interval eccentric cycling protocols in order to test the hypothesis that metabolic demand and enjoyment would be greater for interval than continuous eccentric cycling protocols. Eleven recreationally active men (n = 9) and women (32.6 ± 9.4 years) performed a concentric cycling test to determine peak power output (PPO) followed by five eccentric cycling protocols on separate occasions: continuous eccentric cycling at 60% of PPO for 20 min at 60 rpm (CONT20@60%) and 13.2 min at 90 rpm (CONT13@60%), 4 × 4 min at 75% of PPO with 2-min rest (INT4×4@75%), 12 × 1 min at 100% of PPO with 1-min rest (INT1×12@100%) and 10 × 1 min at 150% of PPO with 1-min rest (INT1×10@150%). Gas exchange and power output were recorded continuously, and rate of perceived exertion (RPE) and enjoyment were assessed after each exercise. Total VO2 including the rest periods was the greatest (p < 0.0001) during INT1×10@150% (382 ± 73 ml kg−1) and lowest (p < 0.0001) during CONT13@60% (146 ± 27 ml kg−1). Total VO2 during INT1×12@100% (312 ± 59 ml kg−1) was greater (p < 0.0001) than CONT20@60% (246 ± 63 ml kg−1) and INT4×4@75% (257 ± 42 ml kg−1). RPE was greater (p < 0.0001) after INT1×10@150% (17 ± 2) than other conditions, but perceived enjoyment was not significantly different between protocols. It was concluded that the interval protocols increased metabolic demand without increasing RPE and enjoyment. It appears that high-intensity interval protocols can be used in eccentric cycling prescription.
The value of the 24-h proteinuria in evaluating the severity of preeclampsia and predicting its adverse maternal outcomes

ABSTRACT Background: To identify the 24-h proteinuria value with quantitative analysis and how it correlates with the severity of preeclampsia and subsequent adverse maternal outcomes in the Chinese population. Study design: Eleven hospitals in 10 provinces across China were chosen, in which 1,738 pregnant women complicated by hypertensive disorders of pregnancy (HDP) with the records of 24 h proteinuria were enrolled. They were allocated into four groups: patients with maximal quantified proteinuria < 0.3 g/24 h (Group 1, n = 328); patients with maximal quantified proteinuria ≥ 0.3 g/24 h and < 2.0 g/24 h (Group 2, n = 638); patients with maximal quantified proteinuria ≥ 2.0 g/24 h and < 5.0 g/24 h (Group 3, n = 353); and patients with maximal quantified proteinuria ≥ 5.0 g/24 h (Group 4, n = 419). Logistic regression analysis were conducted to assess the differences in maternal outcomes between different subgroups of 24-h proteinuria and to identify independent risk factors of adverse maternal outcomes in preeclampsia. The multivariable risk prediction model of adverse maternal outcome for HDP was established with receiver operating characteristic curve (ROC) curve and its predicted value was assessed. Results: Thrombocytopenia and cerebral or visual symptoms were more frequent in Groups 3 and 4 than Groups 1 and 2 but no differences were found between Groups 3 and 4 or Groups 1 and 2. Maternal complications were more frequent in Groups 3 and 4 than in Groups 1 and 2 [Group 3 vs. Group 1, odds ratios (ORs) = 3.359 (1.067–10.571); Group 4 vs. Group 1, OR = 3.628 (1.189–11.086); Group 3 vs. Group 2, OR = 2.845 (1.155–7.003); Group 4 vs. Group 2, OR = 3.082 (1.304–7.288)]. However, no significant difference was found between Groups 4 and 3 or between Groups 2 and 1. The proteinuria ≥ 2 g/24 h had an area under the receiver operating characteristic curve (AUC ROC) of 0.668 (95% confidence interval (CI) 0.632–0.705) for predicting adverse maternal outcome. After adjusting for the effects of other symptoms, signs, and laboratory tests, it was the independent risk factor and predictor factor of the adverse maternal outcome (OR = 3.683, 95% CI 2.439–5.562, P<0.001). The final risk prediction model had an AUC ROC of 0.800 (95% CI 0.769–0.830, P<0.001). Conclusion: The proteinuria ≥ 2 g/24 h is an independent predictive factor of adverse maternal outcomes in preeclampsia, but its individual predictive value is limited. The risk prediction model is effective in assessing the risk of adverse maternal outcomes in patients with HDP.
Diastereomerically Pure 6R- and 6S-3′-Aza-2′-18F-Fluoro-5-Methyltetrahydrofolates Show Unprecedentedly High Uptake in Folate Receptor–Positive KB Tumors

The aim of this study was to develop the radiosyntheses of diastereomerically pure 6R- and 6S-3ʹ-aza-2ʹ-18F-fluoro-5-methyltetrahydrofolate (MTHF) (6R-18F-1 and 6S-18F-1) using the integrated approach and to compare the in vitro and in vivo performance characteristics of both radioligands with the previously reported 3ʹ-aza-2ʹ-18F-fluorofolic acid tracer (18F-2), the oxidized form. Methods: 6R-18F-1, 6S-18F-1, and 18F-2 were radiolabeled with 18F using aromatic nucleophilic substitution reaction. In vitro cell uptake studies and binding affinity assays were performed using folate receptor (FR)-α–expressing KB cells. PET/CT imaging and biodistribution experiments were performed with KB tumor–bearing mice. Results: Reference compounds 6R-1 and 6S-1 were obtained after acidic hydrolysis of the corresponding protected intermediates 6R-3 and 6S-3 in high chemical yields (81%–87%) and chemical purities of more than 95%. 6R-18F-1, 6S-18F-1, and 18F-2 were obtained after a 2-step radiosynthetic procedure in a decay-corrected radiochemical yield of up to 5% and molar radioactivities ranging from 20 to 250 GBq/μmol. In vitro binding affinity studies using FR-α–positive KB cells gave half-maximal inhibitory concentrations of 27.1 ± 3.7 and 23.8 ± 4.0 nM for 6R-1 and 6S-1, respectively, which were higher than for the previously reported 3ʹ-aza-2ʹ-fluorofolic acid 2 (1.4 ± 0.5 nM). Comparably high cell uptake values in FR-α–expressing KB cells were found for all 3 radiofolates. In biodistribution studies, exceptionally high KB tumor uptake value of over 32% injected activity per gram of tissue for both 6R-18F-1 and 6S-18F-1 was observed at 180 min after injection, whereas for 18F-2 only 15% injected activity per gram was found in the KB tumors. Radioactivity uptake in the kidneys, liver, salivary glands, and spleen was substantially different for the 6R- and 6S-diastereoisomers and 18F-2. Excellent KB tumor visualization was found in PET/CT images with 6R-18F-1 and 6S-18F-1, both of which outperformed the corresponding oxidized 18F-2. Conclusion: We have successfully radiolabeled 6R- and 6S-3ʹ-aza-2ʹ-18F-fluoro-5-MTHF with 18F using the integrated approach. Our results suggest that both 6R- and 6S-3ʹ-aza-2ʹ-18F-fluoro-5-MTHF are promising reduced radiofolates for imaging FR-α–expressing cancers.
Comparative estimation of sulfiredoxin levels between chronic periodontitis and healthy patients – A case‐control study

BACKGROUND Growing evidence suggests that oxidative stress forms a key component in the etiopathogenesis of periodontitis. Studies have shown potential antioxidants responsible for combating the pro-oxidants which stress the periodontium. But, peroxiredoxin-sulfiredoxin system is the least explored in periodontal disease. METHODS A case-control study was conducted on 30 participants who fulfilled the inclusion criteria from the Department of Periodontics, Saveetha Dental College and Hospital, Chennai, India. The patients were divided into two groups: 1) Group A- healthy controls (n = 18), 2) Group B- patients with generalized chronic periodontitis (n = 17). Following clinical examination, gingival tissue samples were procured from both the groups and subjected to protein quantification by Lowry method. The samples with adequate protein concentration (n = 30) from the two groups were further analyzed by enzyme-linked immunosorbent assay for estimation of sulfiredoxin levels. RESULTS Sulfiredoxin levels were significantly higher in the gingival tissues of chronic periodontitis patients (171.20 ± 16.97 ng/mL) than in healthy controls (131.20 ± 22.87) with P < 0.001. Also, the levels of sulfiredoxin in gingival tissue of periodontitis patients positively correlated with site-specific probing depth (r = 0.67; P = 0.007) and clinical attachment level (r = 0.55; P = 0.035). CONCLUSIONS The present study was a novel attempt to estimate the levels of sulfiredoxin which was significantly elevated in the diseased sites of patients with chronic periodontitis. Future studies are required to probe the role of sulfiredoxin in the etiopathogenesis of periodontal disease.
Is the COPD Assessment Test sensitive for differentiating COPD patients from active smokers and nonsmokers without lung function impairment? A population-based study

ABSTRACT Objective: To assess COPD Assessment Test (CAT) scores in adults with and without COPD, as well as to compare the CAT scores for nonsmokers, former smokers, and smokers without COPD with those for patients with COPD. Methods: This was a cross-sectional population-based study (the Respira Floripa study). The study included adults ≥ 40 years of age residing in the city of Florianópolis, Brazil. A total of 846 households were surveyed. In addition to completing the Respira Floripa questionnaire and the CAT, participants underwent pulmonary function testing. Results: We analyzed data on 1,057 participants (88.1% of the predicted sample size). A functional diagnosis of COPD was made in 92 participants (8.7%). Of those, 72% were unaware that they had COPD. The mean CAT score was higher in the group of COPD patients than in that of individuals without COPD (10.6 [95% CI: 8.8-12.4] vs. 6.6 [95% CI: 6.1-7.0]; p < 0.01). Individual item scores were significantly higher in the patients with COPD than in the individuals without COPD (p < 0.001), the exception being the scores for the items related to sleep (p = 0.13) and energy (p = 0.08). The mean CAT score was higher in the group of COPD patients than in nonsmokers (5.8 [95% CI: 5.3-6.4]) and former smokers (6.4 [95% CI: 5.6-7.2]; p < 0.05). However, there were no significant differences in the mean CAT score between the group of COPD patients and smokers without COPD (9.5 [95% CI: 8.2-10.8]; p > 0.05), the exception being the mean scores for confidence leaving home (p = 0.02). Conclusions: CAT scores were higher in the group of patients with COPD than in nonsmokers and former smokers without COPD. However, there were no significant differences in CAT scores between COPD patients and smokers without COPD. Smokers with an FEV1/FVC ratio > 0.70 have impaired health status and respiratory symptoms similar to those observed in COPD patients.
Effect of Human Coronavirus OC43 Structural and Accessory Proteins on the Transcriptional Activation of Antiviral Response Elements

Objectives: The molecular mechanisms underlying the pathogenesis of human coronavirus OC43 (HCoV-OC43) infection are poorly understood. In this study, we investigated the ability of HCoV-OC43 to antagonize the transcriptional activation of antiviral response elements. Methods: HCoV-OC43 structural (membrane M and nucleocapsid N) and accessory proteins (ns2a and ns5a) were expressed individually in human embryonic kidney 293 (HEK-293) cells. The transcriptional activation of antiviral response elements was assessed by measuring the levels of firefly luciferase expressed under the control of interferon (IFN)-stimulated response element (ISRE), IFN-β promoter, or nuclear factor kappa B response element (NF-κB-RE). The antiviral gene expression profile in HEK-293 cells was determined by PCR array. Results: The transcriptional activity of ISRE, IFN-β promoter, and NF-κB-RE was significantly reduced in the presence of HCoV-OC43 ns2a, ns5a, M, or N protein, following the challenge of cells with Sendai virus, IFN-α or tumor necrosis factor-α. The expression of antiviral genes involved in the type I IFN and NF-κB signaling pathways was also downregulated in the presence of HCoV-OC43 structural or accessory proteins. Conclusion: Both structural and accessory HCoV-OC43 proteins are able to inhibit antiviral response elements in HEK-293 cells, and to block the activation of different antiviral signaling pathways.
A Prospective Study on the Incidence and Outcomes of Neonatal Thrombocytopenia at a Tertiary Care Facility in Central Saudi Arabia

Background: The incidence of neonatal thrombocytopenia is low, yet highly dependent on the populations studied. Purpose: To assess the incidence of neonatal thrombocytopenia and identify factors associated with its outcomes, namely time to disease onset, recovery duration, and platelet count. Methods: A prospective observational study was conducted between May and October 2013 at a large tertiary care facility in Saudi Arabia. Neonates with a platelet count of fewer than 150,000/&mgr;L of blood were followed up until their recovery or death. Results: The period incidence of neonatal thrombocytopenia was 84/4379 (1.9%). The mortality rate associated with the condition was 68/100,000 births. The male-female ratio of neonates with thrombocytopenia was 2.4:1. The mean (standard deviation) time to disease onset was 1.83 (1.29) days, whereas that of recovery duration was 15.35 (18.46) days. The mean (standard deviation) platelet count at onset was 109,543 (32,826)/&mgr;L of blood, whereas that of the increase in platelet count from onset to recovery was 121,876 (78,218)/&mgr;L of blood. Treatment comprised monitoring/spontaneous recovery (n = 52, 64.2%) or platelet transfusion (n = 9, 11.1%), immunoglobulins (n = 8, 9.9%), or a combination of both (n = 12, 14.8%). Neonates with a higher gestational age (&bgr; = 8061, t = 2.456) and late disease onset (&bgr; = 26,178, t = 3.969) were more likely to have a larger increase in platelet count from onset to recovery than those with a lower gestational age (adjusted P = .017) and earlier disease onset (adjusted P < .001). Implications: The high incidence of neonatal thrombocytopenia in this Middle Eastern setting indicates that it may be dependent on the population studied. Special attention should be focused on neonates of lower gestational ages and with an early disease onset, because their platelet count recovery may be slower than that of the countergroup.
Cross-lingual Argumentation Mining: Machine Translation (and a bit of Projection) is All You Need!

Argumentation mining (AM) requires the identification of complex discourse structures and has lately been applied with success monolingually. In this work, we show that the existing resources are, however, not adequate for assessing cross-lingual AM, due to their heterogeneity or lack of complexity. We therefore create suitable parallel corpora by (human and machine) translating a popular AM dataset consisting of persuasive student essays into German, French, Spanish, and Chinese. We then compare (i) annotation projection and (ii) bilingual word embeddings based direct transfer strategies for cross-lingual AM, finding that the former performs considerably better and almost eliminates the loss from cross-lingual transfer. Moreover, we find that annotation projection works equally well when using either costly human or cheap machine translations. Our code and data are available at http://github.com/UKPLab/coling2018-xling_argument_mining.