Miracle-dz/UniFAR-FTUs huggingface dataset:
Finger dexterity and visual discrimination following two yoga breathing practices

Background: Practicing yoga has been shown to improve motor functions and attention. Though attention is required for fine motor and discrimination tasks, the effect of yoga breathing techniques on fine motor skills and visual discrimination has not been assessed. Aim: To study the effect of yoga breathing techniques on finger dexterity and visual discrimination. Materials and Methods: The present study consisted of one hundred and forty subjects who had enrolled for stress management. They were randomly divided into two groups, one group practiced high frequency yoga breathing while the other group practiced breath awareness. High frequency yoga breathing (kapalabhati, breath rate 1.0 Hz) and breath awareness are two yoga practices which improve attention. The immediate effect of high frequency yoga breathing and breath awareness (i) were assessed on the performance on the O′Connor finger dexterity task and (ii) (in) a shape and size discrimination task. Results: There was a significant improvement in the finger dexterity task by 19% after kapalabhati and 9% after breath awareness (P<0.001 in both cases, repeated measures ANOVA and post-hoc analyses). There was a significant reduction (P<0.001) in error (41% after kapalabhati and 21% after breath awareness) as well as time taken to complete the shape and size discrimination test (15% after kapalabhati and 15% after breath awareness; P<0.001) was also observed. Conclusion: Both kapalabahati and breath awareness can improve fine motor skills and visual discrimination, with a greater magnitude of change after kapalabhati.
Balint Groups as a Means to Increase Job Satisfaction and Prevent Burnout Among General Practitioners

PURPOSE General practitioners (GPs) occupy a central position in health care and often have demanding working situations. This corps shows signs of exhaustion, and many consider quitting their job or plan to retire early. It is therefore urgent to find ways of improving GP’s satisfaction with their work. One approach might be Balint group participation. The aim of this study was to explore GPs’ experience of participating in Balint groups and its influence on their work life. METHODS We conducted a descriptive, qualitative study. Nine GPs who had participated in Balint groups for 3 to 15 years were interviewed. A phenomenologic analysis was carried out to describe the phenomenon of Balint group participation. RESULTS The GPs perceived that their Balint group participation influenced their work life. Analyses revealed several interrelating themes: competence, professional identity, and a sense of security, which increased through parallel processes, creating a base of endurance and satisfaction, thus enabling the GPs to rediscover the joy of being a physician. CONCLUSIONS The GPs in this study described their Balint group participation as beneficial and essential to their work life as physicians in several ways. It seemed to increase their competence in patient encounters and enabled them to endure in their job and find joy and challenge in their relationships with patients. Balint groups might thus help GPs handle a demanding work life and prevent burnout. These groups might not suit all GPs, however, and additional ways to reduce stress and increase job satisfaction should be offered.
Distinguishable Epidemics of Multidrug-Resistant Salmonella Typhimurium DT104 in Different Hosts

Sourcing Antibiotic Resistance It is widely assumed that antibiotic resistance in farm animals contributes in a major way to antibiotic resistance in humans. Mather et al. (p. 1514, published online 12 September; see the Perspective by Woolhouse and Ward) analyzed hundreds of genome sequences from Salmonella isolates collected from both livestock and patients in Scotland between 1990 and 2004. The relative contributions of animal-derived and human-derived sources of infection were quantified and the phylogenetic diversity of resistance profiles was matched with bacterial phylogenies. The results suggest that most human infections are caught from other humans rather than from livestock and that humans harbor a greater diversity of antibiotic resistance. Antibiotic resistance travels in independent epidemics in humans and their livestock. [Also see Perspective by Woolhouse and Ward] The global epidemic of multidrug-resistant Salmonella Typhimurium DT104 provides an important example, both in terms of the agent and its resistance, of a widely disseminated zoonotic pathogen. Here, with an unprecedented national collection of isolates collected contemporaneously from humans and animals and including a sample of internationally derived isolates, we have used whole-genome sequencing to dissect the phylogenetic associations of the bacterium and its antimicrobial resistance genes through the course of an epidemic. Contrary to current tenets supporting a single homogeneous epidemic, we demonstrate that the bacterium and its resistance genes were largely maintained within animal and human populations separately and that there was limited transmission, in either direction. We also show considerable variation in the resistance profiles, in contrast to the largely stable bacterial core genome, which emphasizes the critical importance of integrated genotypic data sets in understanding the ecology of bacterial zoonoses and antimicrobial resistance.
Earth Mover's Distance Pooling over Siamese LSTMs for Automatic Short Answer Grading

Automatic short answer grading (ASAG) can reduce tedium for instructors, but is complicated by free-form student inputs. An important ASAG task is to assign ordinal scores to student answers, given some "model" or ideal answers. Here we introduce a novel framework for ASAG by cascading three neural building blocks: Siamese bidirectional LSTMs applied to a model and a student answer, a novel pooling layer based on earth-mover distance (EMD) across all hidden states from both LSTMs, and a flexible final regression layer to output scores. On standard ASAG data sets, our system shows substantial reduction in grade estimation error compared to competitive baselines. We demonstrate that EMD pooling results in substantial accuracy gains, and that a support vector ordinal regression (SVOR) output layer helps outperform softmax. Our system also outperforms recent attention mechanisms on LSTM states.
VERBAL MEMORY DEFICIT FOLLOWING TRAUMATIC BRAIN INJURY: ASSESSMENT USING ADVANCED MRI METHODS

Traumatic axonal injury resulting in disruption of functional networks in the brain is thought to be a major contributor to cognitive dysfunction in survivors of traumatic brain injury (TBI). 1 However, the true significance of this disruption is not known as current clinical imaging modalities do not directly assess axonal injury or functional network connectivity. Modern MRI techniques such as resting-state fMRI correlation analysis may overcome this limitation.2,3 A 21-year-old right-handed woman presented to the outpatient TBI clinic because she was “having trouble in school and remembering things. ” At 15, she was a passenger in a head-on motor vehicle collision. She had a severe TBI, clavicle fracture, and pulmonary contusions. Her initial Glasgow Coma Score was 4 (range: 3, deeply comatose, to 15, normal). Her initial head CT revealed a large left subdural hematoma with 1 cm left-to-right shift, bifrontal hemorrhagic contusions, subarachnoid hemorrhage, intraventricular hemorrhage, and punctate hemorrhages in the subcortical white matter, pons, and splenium of the corpus callosum. A left craniotomy was performed and the subdural hematoma was evacuated. She made a progressive neurologic recovery over 2 months. At discharge she was able to speak complete sentences and had no cranial nerve, motor, or sensory deficits. However, she has experienced persistent difficulties with memory and concentration affecting school performance and everyday life. Neuropsychological testing at age 21 revealed a moderately severe verbal memory deficit for auditory information but otherwise generally …
In vivo cloning of Erwinia carotovora genes involved in the catabolism of hexuronates

Using the RP4::mini-Mu pULB113 plasmid, an RP4 derivative carrying a deleted Mu prophage which allows the plasmid to pick up any chromosomal DNA segment to form R' plasmids, we cloned all of the genes of Erwinia carotovora involved in the catabolism of the hexuronates and in the transport of these substrates. With the R' plasmids we isolated, we performed complementation analysis and found that, in the Erwinia carotovora strain we used, the genes involved in the catabolism of the hexuronates are clustered in four regions of the chromosome. This genetic organization is compared with that of Escherichia coli K-12.
Presence of clonal T cell populations in chronic B lymphocytic leukemia and smoldering myeloma

Clonality in the non-neoplastic T cell population was investigated in 21 patients with B cell chronic leukemic (B-CLL) or multiple myeloma (MM) by probing for TCR beta chain gene rearrangements using Southern blot analysis. In three patients with a benign form of B-CLL (stage 0), and in one patient with smoldering MM, evidence was found for predominant T cell clones. As cellular immunity against the malignant cells may be important in leukemia, the results are discussed in view of the potential role of T cell immunity in B-CLL and MM.
The management of skin toxicity during cetuximab treatment in advanced colorectal cancer: how much does it cost? A retrospecive economic assessment from a single-center experience.

AIMS AND BACKGROUND Skin rash is a predictable and manageable side effect of anti-EGFR therapy such as cetuximab. The aim of this study is to estimate the costs for the foreseeable management of skin toxicity in patients treated with cetuximab in our institute in order to assess the direct medical economic impact. METHODS AND STUDY DESIGN We retrospectively analyzed all consecutive patients with advanced colorectal cancer treated with cetuximab at our institute from June 2006 to May 2011. We evaluated the severity and mean duration of skin rash for each grade and we identified the costs for the different therapeutic interventions. Patients were treated according to the general consensus management of skin toxicity associated with cetuximab treatment. RESULTS We evaluated 31 patients. The median follow-up was 28.95 months (range, 1.84-75.49). At last follow-up 10 patients (32.3%) were alive with metastases, 18 patients (58.1%) had died, 1 patient (3.2%) was alive without evidence of disease, and 2 patients (6.5%) were lost to follow-up. The median progression-free survival was 8.26 months and the median overall survival 32.89 months. Nineteen patients (61.3%) developed skin toxicities: 7 patients (22.6%) grade 1, 9 patients (29.0%) grade 2, 3 patients (9.7%) grade 3; no grade 4 skin toxicity was observed. The median duration of grade 1 toxicity was 79 days (no specific treatments were started), of grade 2 toxicity 95 days (cost range, € 199.50-294.50) and of grade 3 toxicity 64 days (cost range, € 159.42-233.90). CONCLUSIONS Our experience, through the analysis of nonselected cases, showed that the management of skin toxicities related to cetuximab is not so expensive. We recommend proper care of low-grade toxicities in order to reduce progression to high-grade toxicities and the resulting risk of hospitalization, which really impacts on costs.
Recurrent Peritonitis Episodes in a Continuous Ambulatory Peritoneal Dialysis Patient After Gynecologic Procedures

7. Vaidyanathan S, Valencia J, Kemp C, Zhao C, Yeh CM, Bizot MN, et al. Lack of pharmacokinetic interactions of aliskiren, a novel direct renin inhibitor for the treatment of hypertension, with the antihypertensives amlodipine, valsartan, hydrochlorothiazide (HCTZ) and ramipril in healthy volunteers. Int J Clin Pract 2006; 60:1343–56. 8. Katoh M, Nakajima M, Shimada N, Yamazaki H, Yokoi T. Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists: prediction of in vivo drug–drug interactions. Eur J Clin Pharmacol 2000; 55:843–52. 9. Fang CC, Yen CJ, Chen YM, Chu TS, Lin MT, Yang JY, et al. Diltiazem suppresses collagen synthesis and IL-1β-induced TGF-β1 production on human peritoneal mesothelial cells. Nephrol Dial Transplant 2006; 21:1340–7. 10. Suzuki H, Inoue T, Kobayashi K, Shoda J, Nakamoto H. The newly developed calcium antagonist, azelnidipine, increases drain volume in continuous ambulatory peritoneal dialysis patients. Adv Perit Dial 2006; 22:18–23. 11. Ke CY, Lee CC, Lee CJ, Subeq YM, Lee RP, Hsu BG. Aliskiren ameliorates chlorhexidine digluconate–induced peritoneal fibrosis in rats. Eur J Clin Invest 2010; 40:301–9. doi:10.3747/pdi.2011. 00049
On Convergence Rates of Mixtures of Polynomial Experts

In this letter, we consider a mixture-of-experts structure where m experts are mixed, with each expert being related to a polynomial regression model of order k. We study the convergence rate of the maximum likelihood estimator in terms of how fast the Hellinger distance of the estimated density converges to the true density, when the sample size n increases. The convergence rate is found to be dependent on both m and k, while certain choices of m and k are found to produce near-optimal convergence rates.
The Effects of Evolution Education: Examining Attitudes toward and Knowledge of Evolution in College Courses

The present study examined changes in university students' attitudes toward and knowledge of evolution measured by the previously validated Evolutionary Attitudes and Literacy Survey (EALS) in response to curricular content. Specifically, student responses on the survey were compared across an evolutionary psychology course, an introductory biology course with significant evolutionary content, and a political science course with no evolutionary content. To this end, 868 students were assessed at a large Midwestern U.S. university prior to and following completion of one of the three courses. A multiple group repeated measures confirmatory factor analysis (CFA) was conducted to examine latent mean differences in self-reported Evolution Knowledge/Relevance, Creationist Reasoning, Evolutionary Misconceptions, and Exposure to Evolution. A significant and notable increase in Knowledge/Relevance, as well as decreases in Creationist Reasoning and Evolutionary Misconceptions, was observed for the evolutionary psychology course, whereas the biology course demonstrated no change in Knowledge/Relevance and a significant increase in Evolutionary Misconceptions. The implications of these findings for evolution education are discussed.
The joint estimation of signal and noise from the sum envelope

The separate estimation of carrier strength and of narrowband additive noise strength from N envelope samples is considered. The mathematical problem is one of the joint estimation of the two parameters in the Rice probability-density function. The estimation is useful, for example, in the radar analysis of targets containing both specular and distributed components. In the mathematical analysis, theoretical Cramer-Rao lower bounds on the standard deviation in unbiased estimation are first determined. Estimation procedures based upon the method of maximum likelihood and two simple methods of moments are then developed. An error analysis for each procedure is performed by Monte Carlo simulation. For the purpose of comparison, two direct averaging methods are also analyzed. Results are extended to the case where an additional noise is also present, but with known strength. It is also shown that the time average of a slowly-varying carrier strength can be estimated despite the presence of noise.
Early entrance to the job market and its effect on adult health: evidence from Brazil.

OBJECTIVE To determine the effect of employment in childhood on self-reported health in adulthood. METHOD A cross-sectional household survey, with households selected through two-stage sampling, in urban and rural areas in the northeast and southeast of Brazil. A total of 4940 individuals, aged between 18 and 65 years, were included. The main outcome measure was self-reported health. RESULTS There has been a marked reduction in the proportion of people starting work during childhood although, even in the youngest age group, nearly 20% of males began work when under 10. Early entrance into the labour market is strongly associated with low levels of both education and income, with income differentials remaining at later ages. Age starting work is also linked to current household income, with approximately 35% of those starting work when 15 or over currently in the top quartile of household income, compared with 12% of those starting work when under 10. Males, those living in rural areas, and non-whites are most likely to start work early. In univariate analyses, the younger a person started working, the greater the probability of reporting less than good health status as an adult. This persists through all ages, although the difference attenuates with increasing age. In multivariate analyses, adjustment for education or household income substantially reduces the effect but fails to eliminate it in several age bands up to the age of 48, indicating that age starting work has an independent effect on self-reported health in adulthood. CONCLUSIONS The debate about the appropriate policy response to child labour is complex, requiring a balance between protecting the health of the child and safeguarding the income of the family. These findings indicate the need for more research on the long-term sequelae of beginning work at an early age.
Physical Inactivity as a Predictor of High Prevalence of Hypertension and Health Expenditures in the United States: A Cross-Sectional Study

Purpose : To examine the association between physical activity, prevalence of hypertension, and total healthcare and pharmaceutical expenditure in the United States of America (US). Methods : In this cross-sectional study, adult United States residents were included from the Medical Expenditure Panel Survey (MEPS) for 2002. In the MEPS, physical activity was defined as spending at least 30 min 3 times a week in moderate to vigorous physical activity and the diagnosis of hypertension was based on the patient’s self-report. Logistic and multiple linear regression models were used to calculate the risk of prevalent hypertension in physically inactive individuals and examine the association between physical activity and healthcare expenditure after controlling for confounders. Results : Hypertensive patients who were physically active accounted for 46 % and the risk of hypertension was higher in physically inactive individuals than in those who were physically active (Odds ratio, 1.1; 95 % Confidence interval, 1.07 to 1.12, p < 0.0001). Physical activity in all individuals was associated with a decrease in total healthcare expenditure by US$592 per person (p < 0.0001) and pharmaceutical expenditure by US$125 per person (p < 0.0001). Conclusion : Total healthcare and pharmaceutical expenditures were significantly lower for physically active than physically inactive individuals. Keywords : Physical inactivity, Hypertension, Healthcare expenditure.
Transplantation of Menstrual Blood-Derived Mesenchymal Stem Cells Promotes the Repair of LPS-Induced Acute Lung Injury

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are associated with high morbidity and mortality. Menstrual blood-derived stem cells (MenSCs) have been shown to be good therapeutic tools in diseases such as ovarian failure and cardiac fibrosis. However, relevant studies of MenSCs in ALI have not yet proceeded. We hypothesized that MenSC could attenuate the inflammation in lipopolysaccharide (LPS)-induced ALI and promote the repair of damaged lung. ALI model was induced by LPS in C57 mice, and saline or MenSCs were administered via tail vein after four hours. The MenSCs were subsequently detected in the lungs by a live imaging system. The MenSCs not only improved pulmonary microvascular permeability and attenuated histopathological damage, but also mediated the downregulation of IL-1β and the upregulation of IL-10 in bronchoalveolar lavage fluid (BALF) and the damaged lung. Immunohistochemistry revealed the increased expression of proliferating cell nuclear antigen (PCNA) and the reduced expression of caspase-3 indicating the beneficial effect of MenSCs. Keratinocyte growth factor (KGF) was also upregulated after MenSCs administrated. As shown using transwell co-culture, the MenSCs also could improve the viability of BEAS-2B cells and inhibit LPS-induced apoptosis. These findings suggest that MenSC-based therapies could be promising strategies for treating ALI.
Influence of information and knowledge from biology on the variety of technical solution ideas

Bio-inspired design aims at the development of novel, creative solutions with the potential for innovative technical products. It implies the use of different information sources, such as research publications or videos, and knowledge from biology. The influence of information and knowledge from biology on the variety of solution ideas as one criterion for creativity remains to be examined. In this work, we therefore analyse the impact of information and knowledge from biology on the variety of solution ideas generated by pairs of biologists and mechanical engineers working in uni-and bi-disciplinary pairs. The results show a positive influence of information and knowledge from biology on the variety of solution ideas. Moreover, they indicate the need for a support of biologists and mechanical engineers to effectively increase the variety of solution ideas on different levels of abstraction.
IGF1R gene expression as a predictive marker of response to ionizing radiation for patients with locally advanced HPV16-positive cervical cancer.

AIM The aim of this study was to evaluate the predictive utility of Insulin-like growth factor-1 receptor (IGF1R), IGF1, IGF2, Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and of hemoglobin levels for tumor response to exclusive radiotherapy, in patients with locally advanced Human papillomavirus (HPV) 16-positive cervical cancer. PATIENTS AND METHODS From 102 patients treated at our institutes, 38 patients with histologically-proven HPV16-positive cervical cancer were included in this prospective case-controlled study. All patients underwent exclusive radiotherapy-only. Complete response was defined as an absence of residual disease at clinical examination and radiological imaging, three months after the completion of treatment. Gene expression levels, assessed before radiotherapy, were compared between responders and non-responders. Controls consisted of normal cervical tissue samples from 30 patients with non-oncological indications. RESULTS Twenty patients (52.6%) showed a complete response. Gene expressions of IGF1R (34%), IGF2 (24%), and GAPDH (median=3.26 versus 2.12) were increased in cancer patients, in comparison with the control group. Higher levels of expression of GAPDH were observed in patients co-expressing IGF2 and IGF1R, who had a hemoglobin level ≤ 11 g/dl (p=0.05). Clinical characteristics in the responder and in the non-responder groups were similar. In bi-variate and multi-variate analyses, IGF1R expression was the only factor predictive of response to radiotherapy (p=0.018). Accordingly, patients with IGF1R expression had a 28.6-fold greater risk of treatment failure. CONCLUSION In our study, IGF1R was a strong predictive marker of lack of response to radiotherapy. Larger prospective trials are needed to validate IGF1R as a biomarker of radiation response for patients with HPV16-positive cervical cancer.