Miracle-dz/UniFAR-FTUs huggingface dataset:
Research Performance Based Funding Systems: a Comparative Assessment

Performance based funding is used by most EU Member States to increase the performance of their public research system. This report analyses the different nature of systems in EU Member States, selected associated and third countries. It aims to inform Member States which are in a process of mutual learning to improve the design of their allocation systems. â€¢ Research Performance based funding systems provide incentives to increase scientific performance and concentrates resources in well performing organisations â€¢ The nature of systems in place differs widely â€¢ The specific features of RPBF assessment designs can generate unintended consequences â€¢ The assessment suggests RPBF as a potential avenue for several Member States â€¢ The choice for specific designs, taking into accounts costs and potential benefits, should take into account the national context
‘The New Normal',the Late Stage of Industrialization and the New Power of Industrial Growth

From the analysis of the changes of the growth rate of industry,industrial demand side,industrial structure and regional industry structure,and industrial enterprise performance,all the signs show that Chinese industrial economy is heading for a slow growth,structure optimization,which is 'the new normal',the process of China step into the late stage of industrialization stage.International experience shows that the late stages of industrialization is often tortuous and challenging.For China,in the numerous challenges,she must pay attention to the excess capacity,the transformation and upgrading of the industrial structure and the third industrial revolution.In current China,inferior industry theory is untenable,and the industrial status decline theory is still too early to realise.Facing the new challenges of industrial development,what we have to do is to increase the new power of the industrial economic growth.China industrialization process will provide further impetus to the industrial growth in supply,while China urbanization process will provide the impetus for industrial growth in demand,and comprehensively deepen reform is the source of power.
The Relationship between Spiritual Intelligence and Work Satisfaction among Leaders and Employees

Abstract This study aims to investigate the relationship between spiritual intelligence and work satisfaction among both leaders and employees. Most studies in this area have focused on researching the relationship between employees’ spiritual intelligence and work satisfaction, so we also researched the relationship between leaders’ spiritual intelligence and work satisfaction. Our leading thesis was that leaders and employees with a higher level of spiritual intelligence have a higher level of work satisfaction. In our study, we found no significant relationship between spiritual intelligence and work satisfaction for leaders, but we found a significant positive relationship between spiritual intelligence and workplace satisfaction for employees.
Nuclear Inclusions and Pseudoinclusions: Friends or Foes of the Surgical Pathologist?

Abnormal substances in the nuclei that can be observed by light microscopy are often broadly referred to as nuclear inclusions. Although their recognition in the appropriate clinicopathological settings can aid in the diagnosis of some disease entities and tumor types, they can also be a source of error. There are 2 morphologically distinct types of inclusions with different mechanisms of formation and diagnostic significance, including bona fide nuclear inclusions and nuclear pseudoinclusions. Bona fide nuclear inclusions result from accumulation in the nuclei of viral particles, cytoplasmic materials (such as surfactant, immunoglobulin, and glycogen), biotin, nuclear lamins, or polyglutamine. Some of them are diagnostically helpful, such as surfactant inclusion, which can support the pulmonary origin of an adenocarcinoma, whereas others may be misleading, such as biotin inclusion, which can be mistaken for herpes infection. Nuclear pseudoinclusions, which represent invaginations of cytoplasm into the nucleus, are delimited by the nuclear membrane. Although not totally specific, they are particularly common in papillary thyroid carcinoma, meningioma, and usual ductal hyperplasia of the breast and hence may aid in the diagnosis of these entities. Nuclear pseudo-pseudoinclusions, which are artefactual bubbles in the nuclei that mimic nuclear pseudoinclusions or clear nuclei, can lead to misdiagnosis of follicular adenoma or hyperplastic nodule as papillary thyroid carcinoma.
The effect of different fibre components on growth rate, nutrient digestibility, rate of digesta passage and hindgut fermentation in domesticated rabbits

Trials were conducted to study the effect of dietary fibre on performance and nutrient digestibility in growing rabbits. The basal diet was supplemented with 12% cellulose, pectin, lignin, or alfalfa, in four different treatments. Twenty-four 4-week-old Californian male rabbits were randomly allocated into four groups and placed in individual cages. The lignin supplement severely affected both feed intake and performance, pectin second, with dietary cellulose having the least effect. Dietary lignin significantly decreased the digestibility of crude protein, gross energy and dry matter content (P < 0.05). Rabbits on the pectin supplemented diet digested dry matter, crude fibre and neutral detergent fibre (NDF) better (P < 0.05) than other treatment groups. On the other hand, rabbits in the lignin group digested crude fibre, acid detergent fibre (ADF) and NDF significantly less well than rabbits in other groups (P < 0.05). Dietary lignin also significantly decreased the caecal concentration of volatile fatty acids (VFA, P < 0.05) but did not significantly affect the molar ratios of the VFAs among treatment groups. The turnover rate of the marker, chromic oxide, in the gastrointestinal (GI) tract of rabbits was 64.94, 51.81, 44.05 and 29.59 h in the pectin, alfalfa, lignin and cellulose treatment groups, respectively. The rate of turnover in the digestive tract significantly influenced digestibility of fibre components but did not significantly influence caecal fermentation.
Comparing the effectiveness of different educational programs for patients with total knee arthroplasty.

PURPOSE To compare the effects of preadmission and postadmission educational programs for patients with total knee arthroplasty. DESIGN Quasiexperimental study. SAMPLE 60 total knee arthroplasty patients. METHODS Subjects in the experimental group received preadmission preoperative teaching with an instruction booklet during a preoperative outpatient clinic visit. Upon admission to the hospital, they were presented with an educational video tape. The control group received only postadmission preoperative teaching with the same instruction booklet and no video. PREADMISSION AND POSTADMISSION: Preoperative anxiety level, knowledge about postoperative care, exercise performance and postoperative recovery were used as outcome measures. FINDINGS The research results found: 1. there was no significant difference between the two groups in reduction of preoperative anxiety score: 2. the experimental group had a significantly higher knowledge level than the control group; 3. the experimental group performed exercise more regularly and correctly than those in the control group; 4. the experimental group had greater flexion of the operative knee joint than the control group. CONCLUSION Preadmission teaching with a videotape program and a health manual for patients with total knee arthroplasty is recommended. IMPLICATIONS FOR NURSING RESEARCH More indicators such as postoperative pain and patient satisfaction can be used to investigate the effectiveness of intervention. In addition, increasing the sample size is recommended for future studies.
Atg20- and Atg24-family proteins promote organelle autophagy in fission yeast

ABSTRACT Autophagy cargos include not only soluble cytosolic materials but also bulky organelles, such as ER and mitochondria. In budding yeast, two proteins that contain the PX domain and the BAR domain, Atg20 and Atg24 (also known as Snx42 and Snx4, respectively) are required for organelle autophagy and contribute to general autophagy in a way that can be masked by compensatory mechanisms. It remains unclear why these proteins are important for organelle autophagy. Here, we show that in a distantly related fungal organism, the fission yeast Schizosaccharomyces pombe, autophagy of ER and mitochondria is induced by nitrogen starvation and is promoted by three Atg20- and Atg24-family proteins – Atg20, Atg24 and SPBC1711.11 (named here as Atg24b). These proteins localize at the pre-autophagosomal structure, or phagophore assembly site (PAS), during starvation. S. pombe Atg24 forms a homo-oligomer and acts redundantly with Atg20 and Atg24b, and the latter two proteins can form a hetero-oligomer. The organelle autophagy defect caused by the loss of these proteins is associated with a reduction of autophagosome size and a decrease in Atg8 accumulation at the PAS. These results provide new insights into the autophagic function of Atg20- and Atg24-family proteins. Summary: Fission yeast Atg20- and Atg24-family proteins promote starvation-induced autophagy of ER and mitochondria, and we propose that their function is to ensure that autophagosomes are of a sufficient size.
A Study of Intensified Dietary Support in Underweight Candidates for Lung Transplantation

Background: No data is available on dietary intervention in candidates for lung transplantation and on the effect of different strategies for dietary support in this cohort. Aim: We therefore wanted to evaluate the effects of intensified nutritional support compared with simple support on energy intake and nutritional status. Method: Our participants were underweight (n = 42) and normal-weight (control group, n = 29) candidates for lung transplantation. The underweight patients were randomized into two groups. Group A received intensified dietary counselling, ready-made liquid nutritional supplements free of charge and regular follow-ups, while group B received only one session of individual dietary counselling, no supplements and no follow-ups. Results: The mean intervention time was 21 weeks. Groups A and B both increased their energy intake and gained weight. Group A increased their energy intake from a median of 8.7 to 10.1 MJ (p < 0.01 compared with the control group after intervention) and gained a mean of 2.9 kg body weight (95% CI 1.2; 4.7, p = 0.005 compared with the control group), while group B increased from 7.4 to 10.8 MJ (p = 0.005) and gained 2.3 kg (1.2; 3.3, p = 0.002). Only group B increased their fat-free mass. In this group, an increase in O2 saturation and a decrease in PaCO2 were suggested. None of the groups improved its physical performance. Conclusion: In candidates for lung transplantation we were unable to confirm the hypothesis that intensified nutritional support compared with a simple support increased compliance. Both groups achieved the goal for energy intake and gained weight.
Impact of Lidar Nominal Post-spacing on DEM Accuracy and Flood Zone Delineation

Lidar data have become a major source of digital terrain information for use in many applications including hydraulic modeling and flood plane mapping. Based on established relationships between sampling intensity and error, nominal post-spacing likely contributes significantly to the error budget. Post-spacing is also a major cost factor during lidar data collection. This research presents methods for establishing a relationship between nominal post-spacing and its effects on hydraulic modeling for flood zone delineation. Lidar data collected at a low post-spacing (approximately 1 to 2 m) over a piedmont study area in North Carolina was systematically decimated to simulate datasets with sequentially higher post-spacing values. Using extensive first-order ground survey information, the accuracy of each DEM derived from these lidar datasets was assessed and reported. Hydraulic analyses were performed utilizing standard engineering practices and modeling software (HEC-RAS). All input variables were held constant in each model run except for the topographic information from the decimated lidar datasets. The results were compared to a hydraulic analysis performed on the un-decimated reference dataset. The sensitivity of the primary model outputs to the variation in nominal post-spacing is reported. The results indicate that base flood elevation does not statistically change over the post-spacing values tested. Conversely, flood zone boundary mapping was found to be sensitive to variations in post-spacing.
A longitudinal study of plasma and urinary cortisol in pregnancy and postpartum.

CONTEXT There is a paucity of longitudinal data on plasma and urinary cortisol levels during pregnancy using modern assays. Furthermore, conflicting data exist as to the effect of the low-dose oral contraceptive pill (OCP) on cortisol. DESIGN, SUBJECTS, AND MEASUREMENTS: We conducted a prospective longitudinal study on morning plasma cortisol (total and free), corticosteroid-binding globulin (CBG), and 24-h urinary free cortisol (UFC) levels in 20 pregnant women during the first, second, and third trimesters and 2-3 months postpartum compared with 12 subjects on low-dose OCP and 15 nonpregnant subjects not taking the OCP (control group). RESULTS A progressive rise in total plasma cortisol, CBG, and 24-h UFC was demonstrated during pregnancy, peaking during the third trimester (mean 3-fold rise compared with controls). Plasma free cortisol increased 1.6-fold by the third trimester. In the OCP group, total plasma cortisol and CBG were 2.9- and 2.6-fold elevated, respectively, whereas 24-h UFC and plasma free cortisol were not significantly different from controls. Compared with liquid chromatography-mass spectrometry, a commercial immunoassay underestimated mean total plasma cortisol concentrations by 30% during second and third trimesters and in OCP users and overestimated UFC levels by 30-35% during pregnancy. CONCLUSIONS Our study demonstrated elevations in total plasma cortisol and CBG concentrations during pregnancy and with low-dose OCP use. Pregnancy was also associated with significant increases in plasma free cortisol and UFC, suggesting that the rise in total plasma cortisol is contributed to by up-regulation of the maternal hypothalamic-pituitary-adrenal axis in addition to elevated CBG.
Structural and Functional Characterization of an RNase HI Domain from the Bifunctional Protein Rv2228c from Mycobacterium tuberculosis

ABSTRACT The open reading frame Rv2228c from Mycobacterium tuberculosis is predicted to encode a protein composed of two domains, each with individual functions, annotated through sequence similarity searches. The N-terminal domain is homologous with prokaryotic and eukaryotic RNase H domains and the C-terminal domain with α-ribazole phosphatase (CobC). The N-terminal domain of Rv2228c (Rv2228c/N) and the full-length protein were expressed as fusions with maltose binding protein (MBP). Rv2228c/N was shown to have RNase H activity with a hybrid RNA/DNA substrate as well as double-stranded RNase activity. The full-length protein was shown to have additional CobC activity. The crystal structure of the MBP-Rv2228c/N fusion protein was solved by molecular replacement and refined at 2.25-Å resolution (R = 0.182; R free = 0.238). The protein is monomeric in solution but associates in the crystal to form a dimer. The Rv2228c/N domain has the classic RNase H fold and catalytic machinery but lacks several surface features that play important roles in the cleavage of RNA/DNA hybrids by other RNases H. The absence of either the basic protrusion of some RNases H or the hybrid binding domain of others appears to be compensated by the C-terminal CobC domain in full-length Rv2228c. The double-stranded-RNase activity of Rv2228c/N contrasts with classical RNases H and is attributed to the absence in Rv2228c/N of a key phosphate binding pocket.
Students' Perspective on the Impact of a Web-based Discussion Forum on Student Learning

It is often said that students learn best from their peers, thus it is beneficial to promote student-to-student interactions inside and outside of the classroom. A Web-based discussion forum is one way of facilitating these interactions. At Rochester Institute of Technology, every oncampus course has a Website, which includes e-mail and discussion forum sections, and areas where the course syllabus, homework, and grades can be posted. The level of usage of these course Websites varies across RIT, with many instructors using the Websites solely for posting course syllabus and grades, and few using the discussion forum. The authors conducted a survey of students in the structural analysis and structural loads courses to determine the impact of online discussion forums on student learning in engineering technology on-campus courses. The survey results and correlation of students' participation rates with course grades indicate a positive impact on student learning in these oncampus courses
An interneuronal relay for group I and II muscle afferents in the midlumbar segments of the cat spinal cord.

1. The properties of interneurones located in the 4th lumbar segment of the cat spinal cord (L4 interneurones) have been investigated by intracellular and extracellular recording from individual neurones. The study focused on interneurones projecting to hind‐limb motor nuclei and/or interposed in pathways from group II muscle afferents. The projection to motor nuclei was assessed from antidromic activation of the neurones by stimuli applied in the motor nuclei of the 7th lumbar (L7) segment. 2. Interneurones which projected to gastrocnemius‐soleus or hamstring motor nuclei were found in laminae VI and VII and at the border between laminae VII and VIII. The dominant peripheral input to most of them was from group II muscle afferents, but they were also influenced by group I muscle afferents and by afferents in cutaneous, joint and interosseous nerves. Both excitatory post‐synaptic potentials (e.p.s.p.s) and inhibitory post‐synaptic potentials (i.p.s.p.s) were evoked from all of these fibre systems. 3. The same kind of multimodal input was also found in other interneurones in laminae VI and VII. However, their axonal projections were not identified and they might have included neurones projecting to motor nuclei (though outside the areas which were stimulated) as well as neurones with more local actions. 4. Interneurones located in laminae IV and V of the dorsal horn appeared to constitute a separate functional population since both their projections and their input differed from those of the more ventrally located interneurones; none of the dorsal horn interneurones were found to project to motor nuclei and none had input from group I afferents, although they were influenced by group II muscle afferents and by afferents in cutaneous, joint and interosseous nerves. 5. Many of the excitatory actions from group I and II afferents upon L4 interneurones were found to be evoked monosynaptically. A high proportion of L4 neurones synapsing upon motoneurones would thus be interposed in disynaptic reflex pathways from these afferents. In comparison to actions evoked via interneurones of the caudal lumbar segments, any post‐synaptic potentials (p.s.p.s) evoked via L4 interneurones would be delayed. These delays would amount to 0.4‐0.9 ms for p.s.p.s. from group I afferents and by 0.5‐2.5 ms for group II p.s.p.s. 6. In many interneurones, particularly those located ventrally, i.p.s.p.s. were evoked by group I and II muscle afferents at latencies which indicated that they were evoked disynaptically. They may therefore reflect inhibitory interactions between subpopulations of L4 interneurones. (ABSTRACT TRUNCATED AT 400 WORDS)
Approaches for optimizing the calibration standard of Tewameter TM 300

Abstract: Calibration of devices measuring transepidermal water loss (TEWL) is in intensive discussion. Comparative studies revealed that comparable measuring systems, e.g. open and closed chamber systems, do not always deliver the same results, even when expressing the measured values in SI units, namely in g/m2/h. Therefore, adequate and reliable calibration procedures need to be established. We were able to test the reliability of a multi‐step calibration algorithm for an open chamber system such as Tewameter TM 300. In order to achieve reliable measurements, the maintenance of stable microclimate conditions without air turbulences is mandatory. The TEWL values should be compared with those determined gravimetrically on heated skin simulators. The reproducibility of the results is warranted by consecutive measurements on different adjacent spots of a defined area. Preheating of the probe sensors is an effective approach for shortening the measuring time and gaining a rapid steady‐state. The accurate calibration of the probe can be checked under laboratory conditions any time. The critical point of the calibration and ultimately the accuracy of in vivo measurements maintain the steady functional capacity of the probes during the entire duration of continuous studies. The studied calibration procedure ensures these requirements.
Array‐based comparative genomic hybridization analysis of recurrent chromosome 15q rearrangements

Genomic rearrangements of chromosome 15q11‐q13 cause diverse phenotypes including autism, Prader–Willi syndrome (PWS), and Angelman syndrome (AS). This region is subject to genomic imprinting and characterized by complex combinations of low copy repeat elements. Prader–Willi and Angelman syndrome are caused primarily by 15q11‐13 deletions of paternal and maternal origin, respectively. Autism is seen with maternal, but not paternal, interstitial duplications. Isodicentric 15q, most often of maternal origin, is associated with a complex phenotype often including autistic features. Limitations of conventional cytogenetic tests preclude a detailed analysis in most patients with 15q rearrangements. We have developed a microarray for comparative genomic hybridization utilizing 106 genomic clones from chromosome 15q to characterize this region. The array accurately localized all breakpoints associated with gains or losses on 15q. The results confirmed the location of the common breakpoints associated with interstitial deletions and duplications. The majority of idic(15q) chromosomes are comprised of symmetrical arms with four copies of the breakpoint 1 to breakpoint 5 region. Patients with less common breakpoints that are not distinguished by routine cytogenetic methods were more accurately characterized by array analysis. This microarray provides a detailed characterization for chromosomal abnormalities involving 15q11‐q14 and is useful for more precise genotype–phenotype correlations for autism, PWS, AS, and idic(15) syndrome. © 2005 Wiley‐Liss, Inc.
UvA-DARE ( Digital Academic Repository ) Measuring the effects of genetic testing : studies on thrombophilia , sickle cell trait , recurrent miscarriage and male subfertility

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