Miracle-dz/UniFAR-FTUs huggingface dataset:
Manager's Leadership Is the Main Skill for Ambulatory Health Care Plan Success

To demonstrate effectiveness of ambulatory health care plan implementation among institutions and variables associated with the differences observed. Randomized selection of primary health care (PHC) centers was done. Leadership ability of the plan manager was explored. Univariate/bivariate analyses were performed to observe correlation between variables. Two groups of PHC centers were established according to the efficacy of plan implementation: high and low performance. Differences between groups were observed (592%-1023% more efficacy in controls and practices; P < .001). Leadership was responsible for the main differences observed. Leadership of manager for implementation of the health care plan was the major important variable to reach the best efficacy standards.
KOUNIS SYNDROME SECONDARY TO CEFUROXIME‐AXETIL USE IN AN OCTOGENARIAN

To the Editor: The concurrence of acute coronary syndromes with allergic or hypersensitivity, as well as with anaphylactic or anaphylactoid reactions, is increasingly encountered in clinical practice, and there are several reports associating mast cell activation with acute cardiovascular events in adults. Kounis first described this as ‘‘allergic angina syndrome’’ progressing to ‘‘allergic myocardial infarction. ’’ The main mechanism proposed is the vasospasm of coronary arteries. We present a 90-year-old man, referred to our hospital with thoracic pain, 10 minutes after intramuscular injection of 750 mg of cefuroxime-axetil. Kounis and Zavras described the ‘‘syndrome of allergic angina’’ as the coincidental occurrence of chest pain and allergic reactions accompanied by clinical and laboratory findings of classical angina pectoris caused by inflammatory mediators released during the allergic insult. Allergic angina can progress to acute myocardial infarction, which was named ‘‘allergic myocardial infarction. ’’ Causes of Kounis syndrome include medications (antibiotics, analgesics, antineoplastics, contrast media, corticosteroids, intravenous anesthetics, nonsteroidal antiinflammatory drugs, skin disinfectants, thrombolytics, anticoagulants), various conditions (angio-edema, bronchial asthma, urticaria, food allergy, exercise-induced allergy, mastocytosis, serum sickness), and environmental exposure (ant, bee, wasp, jellyfish stings; grass cutting, millet allergy; poison ivy; latex contact; shellfish eating; viper venom poisoning).
Cardiac side effects of bruton tyrosine kinase (BTK) inhibitors

Abstract The development of bruton tyrosine kinase inhibitors (BTKi) has been a significant advancement in the treatment of chronic lymphocytic leukemia and related B-cell malignancies. As experience in using ibrutinib increased, the first drug to be licensed in its class, atrial fibrillation (AF) emerged as an important side effect. The intersection between BTKi therapy for B-cell malignancies and AF represents a complex area of management with scant evidence for guidance. Consideration needs to be taken regarding the interplay of increased bleeding risk versus thromboembolic complications of AF, drug interactions between ibrutinib and anticoagulants and antiarrhythmic agents, and the potential for other, as yet seldom reported cardiac side effects. This review describes the current knowledge regarding BTKi and potential pathophysiologic mechanisms of AF and discusses the management of BTKi-associated AF. Finally, a review of the second generation BTKi is provided and gaps in knowledge in this evolving field are highlighted.
First-line therapy for chronic phase CML: selecting the optimal BCR-ABL1-targeted TKI

Abstract Patients diagnosed with chronic myeloid leukemia (CML) and treated with BCR-ABL1 tyrosine kinase inhibitors (TKIs) have long life spans. Selection of an appropriate first-line therapy can be difficult as both the unique characteristics of each TKI and patient need to be taken into account to find the optimal match. Patient characteristics include comorbidities, concomitant medications, lifestyle, risk factors, BCR-ABL1 transcript type (e.g. b2a2 or b3a2) and additional chromosomal abnormalities. Just as patients differ, side effects, drug-drug interactions, administration plans, dosing schedules and treatment-related expenses across TKIs also vary. Alignment of these characteristics with the appropriate TKI is key to successfully initiating CML treatment. Continued success relies on communication between the patient and the healthcare team, adherence and optimization of therapy once it is initiated. In this review, we discuss these factors, in addition to TKI efficacy and safety, the cost of therapy, the future of treating CML and treatment-free remission.
Azacytidine in combination with tyrosine kinase inhibitors induced durable responses in patients with advanced phase chronic myelogenous leukemia

Abstract Although the tyrosine kinase inhibitor (TKI) era has brought great improvement in outcome in chronic myelogenous leukemia (CML), prognosis of accelerated phase or myeloid blast crisis patients or of de novo Philadelphia chromosome-positive acute myeloid leukemia remains poor. We conducted a retrospective study on patients with advanced phase disease treated with a TKI and azacytidine. Sixteen patients were eligible. Median age was 64.9 years, the median number of previous therapies was 2.5 lines, and median follow-up was 23.1 months. Hematologic response (HR) rate was 81.3%. Median overall survival (OS), event free survival and relapse-free survival (RFS) were 31.5, 23.3, and 32.2 months, respectively. All except one patient were treated as out-patients after the first cycle. Five patients were bridged to allogenic hematopoietic stem cells transplant. The combination of a TKI and azacytidine is a safe and efficient regiment for patients with CML patients in advanced phases.
Perception of Interactivity: Affects of Four Key Variables in Mobile Advertising

There are indications that interactivity could benefit the effectiveness of mobile advertisements. But there are few guidelines on how to design interactive mobile advertisements. This study investigated the influences of various design features of mobile advertisements on perceived interactivity and the relationship between perceived interactivity and attitude toward mobile advertisements. An experiment consisting of 2 sessions was conducted to test 5 proposed hypotheses with 40 participants. Results showed that the number of user control options and the customizability of advertisements have significant influences on users' perception of interactivity. The more options a message advertisement provides, the more interactive the participants perceive the advertisement; a customizable game advertisement is perceived as more interactive than an uncustomizable game advertisement. But no significant effects of presenting instructional information of mobile Web advertisements and including humorous elements were found. Finally, perceived interactivity was found a strong predictor of attitude toward mobile advertisement.
Actual and Preferred Work Activities of Mental Health Occupational Therapists: Congruence or Discrepancy?

The reform of Australian mental health services has resulted in new models of care and changed work practices for all mental health professionals. Occupational therapists today are as likely to be working in multidisciplinary teams performing a range of generic clinical roles as they are to be working in specialist rehabilitation units. These kinds of changes have taken place in other countries, with anecdotal and some empirical evidence that the changes have resulted in concerns about loss of professional identity and roles. This study sought to identify the current work activities carried out by occupational therapists and to determine whether there was a discrepancy between their actual and desired work activities. It was expected that, overall, they would indicate a preference to do more specialist rehabilitation focused work and less generic case management work. A survey of 196 occupational therapists investigated their actual and preferred work activities in 55 specific roles across four broad categories (senior administration, specialist clinical, general clinical and community development). As expected, the participants indicated that they would prefer to be undertaking more specialist rehabilitation oriented work activities than they were actually doing. Contrary to expectations, they also wished to undertake more rather than less generic clinical work activities, to be more engaged in community development work and to take on more senior and administrative roles. They indicated a preference for less rather than more activity on only 5 of the 55 work roles examined. On examining a subset of 113 participants who reported that 50% or more of their time was spent in case management, there was greater evidence of resistance to generic clinical roles. It was therefore concluded that occupational therapists in Australia are seeking to deploy their specialist skills to a greater degree than the current practice environment permits. They have broadly accepted the generic roles required in multidisciplinary community case management, but those who are actually working in these roles are most likely to have reservations about this kind of work.
Nurse Practitioner Prescriptive Authority for Buprenorphine: From DATA 2000 to CARA 2016

Abstract The aim of this Policy Watch column is to provide an update on a much anticipated legislation, enacted in 2016, which enabled office-based opioid treatment (OBOT) with buprenorphine prescribing for the treatment of opioid addiction by nurse practitioners (as well as physician assistants). First, an overview of the Drug Addiction Treatment Act of 2000, which only permitted OBOT prescribing by physicians, will be described. It will be followed by a summary of the Recovery Enhancement for Addiction Treatment Act of 2015–2016. Finally, a review of the Comprehensive Addiction Recovery Act of 2016 will be provided, which includes information about important changes to OBOT regulations that enable NP prescribing of buprenorphine for the treatment of opioid addiction.
Experimental Assessment of Agent-Supported Electronic Negotiations

This article presents the results of experimental evaluation of the effectiveness of agent support in e-negotiations. The agent-enhanced e-negotiation system eAgora has been used in the experiments. The system features an agent that assists the user in generating candidate offers, evaluating and critiquing incoming offers, and critiquing counteroffers. The work investigates the effects of agent support and task complexity on negotiation performance and perceived measures of usefulness, satisfaction, ease of use, and confidence. Overall, the results support the expectation that use of an agent leads to higher level of negotiation effectiveness, in particular for higher complexity tasks.
An analysis of oral and maxillofacial pathology found in children over a 30-year period.

AIM The vast majority of oral diseases are confined to oral tissues, but numerous underlying systemic conditions may present with signs and symptoms within the oral cavity. Since the epidemiology of diseases is variable between regions, the authors carried out Europe's first paediatric-based survey of oral and maxillofacial pathology specimens submitted for diagnosis. DESIGN All entries for specimens from children between the ages of 0 and 16 years during the 30-year period from 1973 to 2002 were retrieved and compiled into 12 diagnostic categories. RESULTS During the study period, 4406 (8.2%) specimens came from children between the ages of 0 and 16 years, with a male to female ratio of 1.01. The diagnostic category with the largest number of specimens was tooth pathology (22.1%), followed by salivary gland disease (19.1%) and mucosal pathology (12.1%). In all, there were 114 benign tumours of nonodontogenic origin, 43 odontogenic tumours and 31 malignant tumours. The most frequently diagnosed lesions were mucous extravasation cysts, which accounted for over 16% of cases. Periapical pathology in the form of a radicular cyst, residual cyst or chronic periapical granuloma formed almost 13% of all cases. CONCLUSIONS This survey shows that, while nearly 10% of specimens submitted to the authors' laboratory are from children under 16 years of age, the majority of lesions are of a benign nature, requiring minimal intervention; less than 1% of cases comprise malignant lesions. Odontogenic tumours are relatively rare in this age group; however, certain lesions such as adenomatoid odontogenic tumour and ameloblastic fibroma occur predominantly in children and, therefore, remain an important diagnostic consideration.
Embodied Robot versus Virtual Agent: Involvement of Preschool Children in Motor Task Performance

Embodied robots are known to be preferable in most cases to their virtual agents for interaction with and performance by human subjects. This study compared the efficacy of an embodied robot-coacher and its virtual agent in involving preschool children in the performance of playlike motor tasks. The robot or its virtual agent demonstrated movements, asked the children to repeat them, and provided positive feedback on their performance. The difficulty of the motor tasks was increased over the course of the session. Two groups of children were studied, one of them with and the other without previous experience of interaction with the embodied robot. In the experienced group, involvement in motor tasks was successfully induced by both the embodied robot and its virtual agent, but the children interacted less well with the virtual agent than with the embodied robot. Children in the inexperienced group did not interact at all during the experiment with the virtual agent. Because participants in the experiment were preschool children in their natural environment, this study proposes the combined use of an embodied robot and its virtual agent for motor involvement.
Personal Remote Assistance in Ambient Assisted Living—Experimental Research of Elderly People’s Trust and Their Intention to Use

The objective of this article is to analyze the meaning of two different support functions regarding the use of Ambient Assisted Living (AAL). Thirty-two older persons (M age = 69.84, SD = 6.31) and a younger control group (n = 21; M age = 24.71, SD = 2.10) were examined in an experiment with three different tasks using a tablet computer. The first group operated with a mock-up that provided personal remote assistance (PRA) and the second group with one that provided embedded technical assistance (ETA). The main results show that older participants with PRA solve significantly more tasks than people with ETA. Moreover, a significant influence of perceived ease of use with PRA is revealed. Multiple regressions in the senior sample highlight a significant connection between trust in AAL technology and perceived reliability as well as perceived ease of use. No significant correlation between the type of assistance and older persons’ trust, as well as an intention to use AAL, was found.
Novel Approach to Cardiac Alarm Management on Telemetry Units

Background:General medical-surgical units struggle with how best to use cardiac monitor alarms to alert nursing staff to important abnormal heart rates (HRs) and rhythms while limiting inappropriate and unnecessary alarms that may undermine both patient safety and quality of care. When alarms are more often false than true, the nursing staff’s sense of urgency in responding to alarms is diminished. In this syndrome of “clinical alarm fatigue,” the simple burden of alarms desensitizes caregivers to alarms. Noise levels associated with frequent alarms may also heighten patient anxiety and disrupt their perception of a healing environment. Alarm fatigue experienced by nurses and patients is a significant problem and innovative solutions are needed. Objective:The purpose of this quality improvement study was to determine variables that would safely reduce noncritical telemetry and monitor alarms on a general medical-surgical unit where standard manufacturer defaults contributed to excessive audible alarms. Methods:Mining of alarm data and direct observations of staff’s response to alarms were used to identify the self-reset warning alarms for bradycardia, tachycardia, and HR limits as the largest contributors of audible alarms. In this quality improvement study, the alarms for bradycardia, tachycardia, and HR limits were changed to “crisis,” requiring nursing staff to view and act on the alarm each time it sounded. The limits for HR were HR low 45 bpm and HR high 130 bpm. Results:An overall 89% reduction in total mean weekly audible alarms was achieved on the pilot unit (t = 8.84; P < .0001) without requirement for additional resources or technology. Staff and patient satisfaction also improved. There were no adverse events related to missed cardiac monitoring events, and the incidence of code blues decreased by 50%. Conclusions:Alarms with self-reset capabilities may result in an excess number of audible alarms and clinical alarm fatigue. By eliminating self-resetting alarms, the volume of audible alarms and associated clinical alarm fatigue can be significantly reduced without requiring additional resources or technology or compromising patient safety and lead to improvement in both staff and patient satisfaction.
Augmented Presentations: Supporting the Communication in Presentations by Means of Augmented Reality

This work aims to explore the benefits and potential uses of Augmented Reality technology for supporting communication in presentations. This article presents the architecture and implementation of an Augmented Presentation Feedback System. The system allows a speaker equipped with an Augmented Reality Head-Mounted Display to display visual cues depicted over the listeners’ heads. These can be used as a way to provide the speaker with continuous, private, and immediate feedback on his or her explanations. The results of a case study conducted showed that the system not only assists the speaker in adapting the content and pace of the explanation to the listener but also helps to better manage their interventions and improve the flow of the presentation.
Perceived Visual Complexity and Visual Search Performance of Automotive Instrument Cluster: A Quantitative Measurement Study

Advancements in technology have spurred the development of new in-vehicle applications. Drivers are faced with different driving contexts due to an increase in the number of devices that provide a wealth of diverse information. However, such a scenario can cause drivers to become distracted. Therefore, research on how the presentation of visual information can affect drivers’ performance is important. In this study, an analysis of quantifiable measurements that affect drivers’ perception of visual complexity and visual search performance was conducted. A questionnaire was administered to assess subjective perception of visual complexity, and a user experiment using eye tracking was designed to explore participants’ visual search performance. The results of subjective visual complexity perception and visual search performance suggested that some objective measurement variables were significantly related only to perceived visual complexity, whereas others affected both subjective and behavioral measurements. Thus it is possible to predict which quantifiable measurement variables affect subjective perception of visual complexity and which affect visual search performance. Therefore, this study allows understanding and explaining of perception of visual complexity by quantifiable measurements and the different ways by which these measurements affect visual search performance.
Perceived Visual Complexity of In-Vehicle Information Display and Its Effects on Glance Behavior and Preferences

ABSTRACT Despite enhancements in the visual complexity of in-vehicle information display in recent years, few studies have examined the effects of such increased complexity. We conducted this study with the following objectives: (1) to suggest a framework for predicting the perceived visual complexity (PVC) of in-vehicle information display; (2) to examine the effects of PVC on the visual behavior of human operators; (3) to investigate the relationship between preferences and PVC. A theoretical framework to evaluate PVC was developed, and a survey study was used to collect participants’ perceptions on visual complexity. A regression analysis was employed to find the relationship between each of three factors and PVC. Two of the factors—quantity and variety—showed a positive correlation with PVC, whereas the third factor, relation, exhibited a negative correlation. Visual search experiments were conducted to test the effects of PVC on the performance of visual search tasks and glance behavior. The results showed that the high level of PVC leads to more time-on-task and number of fixations. We also found that preference for in-vehicle information displays was inversely proportional to PVC. The results enable us to predict how human operators perceive visual complexity and explain the influence of PVC on human behavior.
Theory, Practice and Policy: An Inquiry into the Uptake of HCI Practices in the Software Industry of a Developing Country

ABSTRACT With almost four decades of existence as a community, human–computer interaction (HCI) practice has yet to diffuse into a large range of software industries globally. A review of existing literature suggests that the diffusion of HCI practices in software organizations lacks theoretical guidance. Although many studies have tried to facilitate HCI uptake by the software industry, there are scarce studies that consider HCI practices as innovations that software organizations could or should adopt. Furthermore, there appears to be a lack of structure in the facilitation of HCI methodological development within the specialized emerging regions field such as Sub-Saharan Africa. In order to address this gap, an exploratory investigation regarding the state of uptake of HCI practices in Nigeria is conducted. The aim of this article is to improve our understanding regarding the state of HCI uptake in developing countries and the challenges prevailing. The findings show that HCI practice still remains within its infancy stage in most software companies. Universities are also lacking the required knowledge transfer of HCI to the students, and in effect themselves contributing to the lack of HCI skills in industry. Furthermore, government policies are in need of refinement and end-users’ involvement in software development is not prioritized.
Factors Affecting Web Portal Information Services Usability: A Canonical Correlation Analysis

ABSTRACT This study employed canonical correlation analysis to determine which of the possible combinations of student, web portal design, and objective measure-related factors might influence both frequency and satisfaction of use of the web portal information services (WPIS). Data gathered from the two studies revealed that usability of WPIS is a combination of self-initiative, commitment, content, availability, speed, esthetics, ease of use, and effectiveness of WPIS. Thus, the null hypothesis stating that the predictor variable set cannot explain any of the variance of the dependent variables was rejected. It was concluded that the WPIS usability was more sensitive to design-related factors than the student-related factors. It was likewise shown that effectiveness is a design consideration and not a dimension of usability in the context of web portal. Further, it was disclosed that initiative and commitment and not external pressure influence the usability of WPIS. Limitations and recommendations were also offered.