Miracle-dz/UniFAR-FTUs huggingface dataset:
A Simple Unified Framework for Detecting Out-of-Distribution Samples and Adversarial Attacks

Detecting test samples drawn sufficiently far away from the training distribution statistically or adversarially is a fundamental requirement for deploying a good classifier in many real-world machine learning applications. However, deep neural networks with the softmax classifier are known to produce highly overconfident posterior distributions even for such abnormal samples. In this paper, we propose a simple yet effective method for detecting any abnormal samples, which is applicable to any pre-trained softmax neural classifier. We obtain the class conditional Gaussian distributions with respect to (low- and upper-level) features of the deep models under Gaussian discriminant analysis, which result in a confidence score based on the Mahalanobis distance. While most prior methods have been evaluated for detecting either out-of-distribution or adversarial samples, but not both, the proposed method achieves the state-of-the-art performances for both cases in our experiments. Moreover, we found that our proposed method is more robust in harsh cases, e.g., when the training dataset has noisy labels or small number of samples. Finally, we show that the proposed method enjoys broader usage by applying it to class-incremental learning: whenever out-of-distribution samples are detected, our classification rule can incorporate new classes well without further training deep models.
Polynomial bounds for centered colorings on proper minor-closed graph classes

For $p\in \mathbb{N}$, a coloring $\lambda$ of the vertices of a graph $G$ is {\em{$p$-centered}} if for every connected subgraph~$H$ of $G$, either $H$ receives more than $p$ colors under $\lambda$ or there is a color that appears exactly once in $H$. In this paper, we prove that every $K_t$-minor-free graph admits a $p$-centered coloring with $\mathcal{O}(p^{g(t)})$ colors for some function $g$. In the special case that the graph is embeddable in a fixed surface $\Sigma$ we show that it admits a $p$-centered coloring with $\mathcal{O}(p^{19})$ colors, with the degree of the polynomial independent of the genus of $\Sigma$. This provides the first polynomial upper bounds on the number of colors needed in $p$-centered colorings of graphs drawn from proper minor-closed classes, which answers an open problem posed by Dvoř{a}k. As an algorithmic application, we use our main result to prove that if $\mathcal{C}$ is a fixed proper minor-closed class of graphs, then given graphs $H$ and $G$, on $p$ and $n$ vertices, respectively, where $G\in \mathcal{C}$, it can be decided whether $H$ is a subgraph of $G$ in time $2^{\mathcal{O}(p\log p)}\cdot n^{\mathcal{O}(1)}$ and space $n^{\mathcal{O}(1)}$.
Uterine Necrosis after Uterine Artery Embolization for Symptomatic Fibroids

Introduction Uterine artery embolization (UAE) is a minimally invasive intervention that is used in the treatment of fibroids. UAE can lead to complications including postembolization syndrome, postprocedure pain, infection, endometrial atrophy leading to secondary amenorrhea, and uterine necrosis. Uterine necrosis after UAE is very rare and hence poses a clinical dilemma for any clinician in its identification and management. We document a case of uterine necrosis after UAE and conduct a literature review on its causation, clinical features, and management principles. Case A patient presented one month after UAE with abdominal pain and abdominal vaginal discharge. Her work-up revealed features of possible uterine necrosis with sepsis and she was scheduled for a laparotomy and a subtotal hysterectomy was performed. She was subsequently managed with broad spectrum antibiotic and recovered well. Conclusion Uterine necrosis after UAE is a rare occurrence and we hope the documentation of this case will add to the body of knowledge around it. Theories that explain its occurrence include the use of small particles at embolization, the use of Contour-SE a spherical poly-vinyl alcohol, and lack of collateral supply to the uterus. Its symptoms may be nonspecific but unremitting abdominal pain is invariably present. Finally although conservative management may be successful at times, surgical management with hysterectomy will be required in some cases. The prognosis is good after diagnosis and surgical management.
Effect of Perceived Negative Workplace Gossip on Employees’ Behaviors

Negative workplace gossip generates social undermining and great side effects to employees. But, the damage of negative gossip is mainly aimed at the employee who perceived being targeted. The purpose of this study is to develop a conceptual model in which perceived negative workplace gossip influences employees in-role behavior and organizational citizenship behavior differentially by changing employees’ self-concept (organizational-based self-esteem and perceived insider status). 336 employees from seven Chinese companies were investigated for empirical analysis on proposed hypotheses, and results show that: (1) Perceived negative workplace gossip adversely influences employees’ IRB and OCB. (2) Self-concept (OBSE and PIS) plays a mediating role in the relationship between perceived negative workplace gossip and employees’ behaviors (IRB and OCB). (3) Employees’ hostile attribution bias moderates the relationship between perceived negative workplace gossip and self-concept (OBSE and PIS); and also moderates the mediating effect of self-concept (OBSE and PIS) on the relationship between perceived negative workplace gossip and employees’ behaviors (IRB and OCB). Thus, our findings provide deeper insights into the potential harmful effects of gossip. In addition, we help to explain the underlying mechanism and boundary condition of these effects.
Scalable Sparse Subspace Clustering via Ordered Weighted l1 Regression

The main contribution of the paper is a new approach to subspace clustering that is significantly more computationally efficient and scalable than existing state-of-the-art methods. The central idea is to modify the regression technique in sparse subspace clustering (SSC) by replacing the $\ell_{1}$ minimization with a generalization called Ordered Weighted $\ell_{1}$ (OWL) minimization which performs simultaneous regression and clustering of correlated variables. Using random geometric graph theory, we prove that OWL regression selects more points within each subspace than $\ell_{1}$, resulting in better clustering results. This allows for accurate subspace clustering based on regression solutions for only a small subset of the total dataset, significantly reducing the computational complexity compared to SSC. In experiments, we find that our OWL approach can achieve a speedup of $ 20\times$ to $30\times$ for synthetic problems and $4\times$ to $8\times$ on real data problems.
The Globodera pallida SPRYSEC Effector GpSPRY-414-2 That Suppresses Plant Defenses Targets a Regulatory Component of the Dynamic Microtubule Network

The white potato cyst nematode, Globodera pallida, is an obligate biotrophic pathogen of a limited number of Solanaceous plants. Like other plant pathogens, G. pallida deploys effectors into its host that manipulate the plant to the benefit of the nematode. Genome analysis has led to the identification of large numbers of candidate effectors from this nematode, including the cyst nematode-specific SPRYSEC proteins. These are a secreted subset of a hugely expanded gene family encoding SPRY domain-containing proteins, many of which remain to be characterized. We investigated the function of one of these SPRYSEC effector candidates, GpSPRY-414-2. Expression of the gene encoding GpSPRY-414-2 is restricted to the dorsal pharyngeal gland cell and reducing its expression in G. pallida infective second stage juveniles using RNA interference causes a reduction in parasitic success on potato. Transient expression assays in Nicotiana benthamiana indicated that GpSPRY-414-2 disrupts plant defenses. It specifically suppresses effector-triggered immunity (ETI) induced by co-expression of the Gpa2 resistance gene and its cognate avirulence factor RBP-1. It also causes a reduction in the production of reactive oxygen species triggered by exposure of plants to the bacterial flagellin epitope flg22. Yeast two-hybrid screening identified a potato cytoplasmic linker protein (CLIP)-associated protein (StCLASP) as a host target of GpSPRY-414-2. The two proteins co-localize in planta at the microtubules. CLASPs are members of a conserved class of microtubule-associated proteins that contribute to microtubule stability and growth. However, disruption of the microtubule network does not prevent suppression of ETI by GpSPRY-414-2 nor the interaction of the effector with its host target. Besides, GpSPRY-414-2 stabilizes its target while effector dimerization and the formation of high molecular weight protein complexes including GpSPRY-414-2 are prompted in the presence of the StCLASP. These data indicate that the nematode effector GpSPRY-414-2 targets the microtubules to facilitate infection.
Effect of caspases and RANKL induced by heavy force in orthodontic root resorption

Objective Orthodontic root resorption (ORR) due to orthodontic tooth movement is a difficult treatment-related adverse event. Caspases are important effector molecules for apoptosis. At present, little is known about the mechanisms underlying ORR and apoptosis in the cementum. The aim of the present in vivo study was to investigate the expression of tartrate-resistant acid phosphatase (TRAP), caspase 3, caspase 8, and receptor activator of nuclear factor kappa-B ligand (RANKL) in the cementum in response to a heavy or an optimum orthodontic force. Methods The maxillary molars of male Wistar rats were subjected to an orthodontic force of 10 g or 50 g using a closed coil spring. The rats were sacrificed each experimental period on days 1, 3, 5, and 7 after orthodontic force application. And the rats were subjected to histopathological and immunohistochemical analyses. Results On day 7 for the 50-g group, hematoxylin and eosin staining revealed numerous root resorption lacunae with odontoclasts on the root, while immunohistochemistry showed increased TRAP- and RANKL-positive cells. Caspase 3- and caspase 8-positive cells were increased on the cementum surfaces in the 50-g group on days 3 and 5. Moreover, the number of caspase 3- and caspase 8-positive cells and RANKL-positive cells was significantly higher in the 50-g group than in the 10-g group. Conclusions In our rat model, ORR occurred after apoptosis was induced in the cementum by a heavy orthodontic force. These findings suggest that apoptosis of cementoblasts is involved in ORR.
Neuropeptide Y1 and alpha‐1 adrenergic receptor‐mediated decreases in functional vasodilation in gluteus maximus microvascular networks of prediabetic mice

Prediabetes is associated with impaired contraction‐evoked dilation of skeletal muscle arterioles, which may be due to increased sympathetic activity accompanying this early stage of diabetes disease. Herein, we sought to determine whether blunted contraction‐evoked vasodilation resulted from enhanced sympathetic neuropeptide Y1 receptor (Y1R) and alpha‐1 adrenergic receptor (α1R) activation. Using intravital video microscopy, second‐, third‐, and fourth‐order (2A, 3A, and 4A) arteriolar diameters were measured before and following electrical field stimulation of the gluteus maximus muscle (GM) in prediabetic (PD, Pound Mouse) and control (CTRL, c57bl6, CTRL) mice. Baseline diameter was similar between groups; however, single tetanic contraction (100 Hz; 400 and 800 msec) and sustained rhythmic contraction (2 and 8 Hz, 30 sec) evoked rapid onset vasodilation and steady‐state vasodilatory responses that were blunted by 50% or greater in PD versus CTRL. Following Y1R and α1R blockade with sympathetic antagonists BIBP3226 and prazosin, contraction‐evoked arteriolar dilation in PD was restored to levels observed in CTRL. Furthermore, arteriolar vasoconstrictor responses to NPY (10−13–10−8 mol/L) and PE (10−9–10−5 mol/L) were greater in PD versus CTRL at higher concentrations, especially at 3A and 4A. These findings suggest that contraction‐evoked vasodilation in PD is blunted by Y1R and α1R receptor activation throughout skeletal muscle arteriolar networks.
Characterization of whole-body muscle activity during reaching movements using space-by-time modularity and functional similarity analysis

Voluntary movement is hypothesized to rely on a few low-dimensional structures, termed muscle synergies, whose recruitment translates task goals into effective muscle activity. However, the relationship of the synergies with the characteristics of the performed movements remains largely unexplored. To address this question, we recorded a comprehensive dataset of muscle activity during a variety of whole-body pointing movements. We decomposed the electromyographic (EMG) signals using a space-by-time modularity model which encompasses the main types of synergies. We then used a task decoding and information theoretic analysis to probe the role of each synergy by mapping it to specific task parameters. We found that the temporal and spatial aspects of the movements were encoded by different temporal and spatial muscle synergies, respectively, indicating that the identified synergies are tailored with complementary roles to account for the major movement attributes. This approach led to the development of a novel computational framework for comparing muscle synergies from different datasets according to their functional role. This functional similarity analysis yielded a small set of temporal and spatial synergies that describes the main features of whole-body reaching.
PD-L1 Expression and CD8+ T Cell Infiltration Predict a Favorable Prognosis in Advanced Gastric Cancer

Advanced gastric cancer (AGC) has high morbidity and mortality in East Asia, and it is urgent to explore new treatments to improve patient prognosis. Programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) inhibitors have exhibited remarkable activity in clinical trials and were approved by the FDA for clinical therapy in several types of tumors. Here, we evaluated PD-L1 expression and T cell infiltration in AGC. Positive tumor PD-L1 expression was detected in 171 AGCs (33.60%) out of 509 AGCs. PD-L1 expression was positively correlated with CD8+ T cell infiltration. Then, PD-L1 and CD8A mRNA expression was analyzed using gastric cancer data from the TCGA database, confirming a positive correlation. Patient survival was assessed according to PD-L1 status and the T cell infiltration density. PD-L1 expression and a high density of CD8+ T cells in AGCs were associated with improved prognosis, whereas no significant difference was noted between PD-1 and CD3 expression. In contrast, a high density of FOXP3+ T cells in AGCs indicated a poor prognosis. Multivariate Cox regression analysis revealed that CD8+ T cell density acts as an independent predictor of overall survival (OS) in AGC patients. Taken together, this study further highlights targets for immune checkpoint-based therapy in AGC.
Efficient Sampling of SAT Solutions for Testing

In software and hardware testing, generating multiple inputs which satisfy a given set of constraints is an important problem with applications in fuzz testing and stimulus generation. However, it is a challenge to perform the sampling efficiently, while generating a diverse set of inputs which satisfy the constraints. We developed a new algorithm QuickSampler which requires a small number of solver calls to produce millions of samples which satisfy the constraints with high probability. We evaluate QuickSampler on large real-world benchmarks and show that it can produce unique valid solutions orders of magnitude faster than other state-of-the-art sampling tools, with a distribution which is reasonably close to uniform in practice.
Females Are More Sensitive to Opponent’s Emotional Feedback: Evidence From Event-Related Potentials

It is widely believed that females outperformed males in emotional information processing. The present study tested whether the female superiority in emotional information processing exists in a naturalistic social-emotional context, if so, what the temporal dynamics underlies. The behavioral and electrophysiological responses were recorded while participants were performing an interpersonal gambling game with opponents’ facial emotions given as feedback. The results yielded that emotional cues modulated the influence of monetary feedback on outcome valuation. Critically, this modulation was more conspicuous in females: opponents’ angry expressions increased females’ risky tendency and decreased the amplitude of reward positivity (RewP) and feedback P300. These findings indicate that females are more sensitive to emotional expressions in real interpersonal interactions, which is manifested in both early motivational salience detection and late conscious cognitive appraisal stages of feedback processing.
With Friends Like These, Who Needs Adversaries?

The vulnerability of deep image classification networks to adversarial attack is now well known, but less well understood. Via a novel experimental analysis, we illustrate some facts about deep convolutional networks for image classification that shed new light on their behaviour and how it connects to the problem of adversaries. In short, the celebrated performance of these networks and their vulnerability to adversarial attack are simply two sides of the same coin: the input image-space directions along which the networks are most vulnerable to attack are the same directions which they use to achieve their classification performance in the first place. We develop this result in two main steps. The first uncovers the fact that classes tend to be associated with specific image-space directions. This is shown by an examination of the class-score outputs of nets as functions of 1D movements along these directions. This provides a novel perspective on the existence of universal adversarial perturbations. The second is a clear demonstration of the tight coupling between classification performance and vulnerability to adversarial attack within the spaces spanned by these directions. Thus, our analysis resolves the apparent contradiction between accuracy and vulnerability. It provides a new perspective on much of the prior art and reveals profound implications for efforts to construct neural nets that are both accurate and robust to adversarial attack.
Protective Ability of Biogenic Antimicrobial Peptide Microcin J25 Against Enterotoxigenic Escherichia Coli-Induced Intestinal Epithelial Dysfunction and Inflammatory Responses IPEC-J2 Cells

Poison of intestinal induce severe health problems in human infants and young animals due to contaminating foods and feedstuffs. With the emergence of public health concerns and high-speed diffuse of drug-opposition of bacteria, the adoption of antimicrobial peptides as potential candidates in treating pathogen infections raised up. Nature Microcin J25 (MccJ25), a class of lasso peptides separated from a fecal strain of E. coli, has been replied to display powerful antimicrobial behavior. Herein, the study was to assess the usefulness of biogenic MccJ25 in the prophylaxis of ETEC K88 infection in IPEC-J2 cells. In vitro antimicrobial activity against ETEC K88 and cytotoxicity of biogenic MccJ25 were determined first. To further understand how biogenic MccJ25 mediates its impact, ETEC K88 adhesion in cells, membrane permeability [as indicated by reduced release of lactate dehydrogenase (LDH)], transepithelial electrical resistance (TEER), barrier function, and proinflammatory cytokines levels were determined in IPEC-J2 cells after treatment with biogenic MccJ25 and challenge with ETEC K88. Biogenic MccJ25 had a minimum inhibitory concentration of 0.25 μg/mL against ETEC K88, decreased ETEC K88 adhesion in cells and did not cause cytotoxicity toward cells. Furthermore, biogenic MccJ25 protects against ETEC-induced barrier dysfunction by increasing the TEER, decreasing the LDH and promoting tight junction proteins (TJPs) by promoting the assembly of occludin and claudin-1 in the tight junction complex. Biogenic MccJ25 was further found to relieve inflammation responses through modulation of interleukine-6, IL-8 and tumor necrosis factor-α levels via inhibition of mitogen-activated protein kinase (MAPK) and nuclear factor κB activation. In summary, biogenic MccJ25 can protects against ETEC K88-induced intestinal damage and inflammatory response, recommend the hidden adoption of biogenic MccJ25 as a novel prophylactic agent to reduce pathogen infection in animals, food or humans.
A biomechanical case study on the optimal orthodontic force on the maxillary canine tooth based on finite element analysis

Excessive forces may cause root resorption and insufficient forces would introduce no effect in orthodontics. The objective of this study was to investigate the optimal orthodontic forces on a maxillary canine, using hydrostatic stress and logarithmic strain of the periodontal ligament (PDL) as indicators. Finite element models of a maxillary canine and surrounding tissues were developed. Distal translation/tipping forces, labial translation/tipping forces, and extrusion forces ranging from 0 to 300 g (100 g=0.98 N) were applied to the canine, as well as the force moment around the canine long axis ranging from 0 to 300 g·mm. The stress/strain of the PDL was quantified by nonlinear finite element analysis, and an absolute stress range between 0.47 kPa (capillary pressure) and 12.8 kPa (80% of human systolic blood pressure) was considered to be optimal, whereas an absolute strain exceeding 0.24% (80% of peak strain during canine maximal moving velocity) was considered optimal strain. The stress/strain distributions within the PDL were acquired for various canine movements, and the optimal orthodontic forces were calculated. As a result the optimal tipping forces (40–44 g for distal-direction and 28–32 g for labial-direction) were smaller than the translation forces (130–137 g for distal-direction and 110–124 g for labial-direction). In addition, the optimal forces for labialdirection motion (110–124 g for translation and 28–32 g for tipping) were smaller than those for distal-direction motion (130–137 g for translation and 40–44 g for tipping). Compared with previous results, the force interval was smaller than before and was therefore more conducive to the guidance of clinical treatment. The finite element analysis results provide new insights into orthodontic biomechanics and could help to optimize orthodontic treatment plans.