Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinical outcome of one-third–dose depot triptorelin is the same as half-dose depot triptorelin in the long protocol of controlled ovarian stimulation

OBJECTIVE: Appropriate dosage of the long-acting depot gonadotrophin releasing hormone (GnRH) agonist has not been determined in long protocol for IVF, and one-third-dose depot triptorelin was compared with half-dose in a luteal long protocol of in-vitro fertilization/ intra cytoplasmic sperm injection (IVF/ICSI) treatment in this study. MATERIALS AND METHODS: This is a prospective, randomized, open clinical trial. 100 patients were randomized into two groups. Group I received one-third-dose (1.25 mg) depot triptorelin. Group II received half-dose (1.87 mg). The clinical and experimental parameters were compared between the two groups. RESULTS: There was no premature luteinizing hormone (LH) surge in both groups. On Day 3–5 of menstrual cycle after down-regulation, fewer patients showed low-level LH (<1.0 IU/L) and estradiol (<30 pg/mL) in group I (P <0.05). There were fewer oocytes retrieved (P =0.086), fewer total embryos and available embryos for cryopreservation in Group I (P <0.05), while good-quality embryo rate was higher in group I (P <0.05). The length and dose of ovarian stimulation was lower in Group I, but not significantly. The clinical pregnancy (52% versus 40%), implantation (48% versus 37.5%), delivery (46% versus 32%), or live birth (42% versus 32%) rates and the abortion (8% versus 20%) rates showed no significant differences. CONCLUSION: Depot triptorelin 1.25 mg can be successfully used with reduced pituitary suppression and lower cost in a long protocol for in-vitro fertilization.
Prevalence, risk factors, management, and treatment outcomes of first‐line antituberculous drug‐induced liver injury: a prospective cohort study

Antituberculosis drug‐induced liver injury (ATDILI) is one of the most deleterious side effects associated with chemotherapy against tuberculosis (TB). In this study, our objective was to determine the incidence, risk factors, and management of ATDILI and analyze its impact on the treatment outcome in patients receiving standard anti‐TB chemotherapy.
Experiencia y actitudes de los profesionales de salud mental en torno a las prácticas coercitivas directas: revisión bibliográfica de estudios cualitativos

Esta revision bibliografica de estudios cualitativos trata de explorar cuales son las experiencias y actitudes que tienen los profesionales del ambito de la salud mental sobre practicas coercitivas como la contencion mecanica. Existen multiples estudios que indagan en las experiencias de los usuarios; sin embargo, parece necesario conocer la actitud de los profesionales si se desea trabajar por un cambio de paradigma. Se incluyeron 27 estudios que cumplian los criterios de inclusion y de calidad CASPe para estudios cualitativos. En general, los profesionales sienten malestar hacia las practicas coercitivas, aunque existe cierta inclinacion a justificar estas medidas como inevitables ante determinadas situaciones. Aparece una tendencia en los profesionales a atribuir a factores internos de los pacientes las potenciales situaciones desencadenantes. Se identifican tambien propuestas comunes (a nivel estructural, formativo, organizativo y educacional) para una reduccion en el uso de las medidas senaladas.
Prediction of probable Alzheimer's disease in memory-impaired patients

We determined whether a battery of neuropsychological tests could predict who would develop Alzheimer's disease (AD) in a group of 123 memory-impaired nondemented patients. Patients were followed longitudinally for 2 years with a research battery of neuropsychological tests. After 2 years, 29 developed probable AD, and 94 did not develop dementia. We used logistic regression analyses to examine the classification accuracy of subjects' performance at entry to the study on the research battery. The logistic regression model was significant with an accuracy of 89%, sensitivity of 76%, and specificity of 94%. Two tests contributed significantly to this model: the delayed recall from the Rey Auditory Verbal Learning Test and the Mental Control subtest of the Wechsler Memory Scale. These two tests alone produced the same accuracy, sensitivity, and specificity as the larger model. These results demonstrate that probable AD can be predicted with a high degree of accuracy and with a relatively brief battery of neuropsychological tests.
Effects of restricted feeding ration on growth and body composition of juvenile Pangasianodon hypophthalmus

Feeding trial was conducted to investigate the growth response and body composition of juvenile P. hypothalamus with initial body weight 1.2 ± 0.019 g. Diet (35% protein,3% lipid) were fed at the rate 4, 6, 8, 10 and 12 percent bodyweight for a period of 60 days. At the end of feeding period fishes showed significant difference in length gain, weight gain, specific growth rate, feed conversion efficiency, protein efficiency ratio, lipid efficiency ratio and voluntary feed intake. The relationship between the specific growth rate in wet weight (SGRw,) and ration level (RL) showed an asymptotic curve which is described as SGRw = 0.6380 + 0.4344RL 0.0712RL; R = 0.9272 while FCE = 0.8431 0.09785RL 0.01933RL; R = 0.9272. Feed conversion efficiency decreased significantly with increase in ration levels.
Ethical dilemmas confronting dentists in Queensland, Australia.

BACKGROUND This paper details contemporary ethical dilemmas encountered by Queensland dentists. METHODS An age-stratified sample of 499 dentists resident in Queensland was surveyed. The questionnaire contained scenarios of five common ethical dilemmas. In addition, open-ended questions sought the respondent's most frequent, difficult and recent ethical dilemmas, and where they would seek guidance in dealing with ethical problems. RESULTS Respondents acknowledged the patient's rights in treatment decisions and the dentist's right to refuse demands for inappropriate treatment. However, responses varied in the extent to which dentists may influence treatment decisions. Few respondents would ignore evidence of poor dental treatment but they are evenly divided in choosing to inform the patient, the dentist or both. Poor quality treatment is the most frequent and difficult dilemma, and half have experienced this problem recently. Requests by patients for fraudulent receipts occur in a third of responses. Dentists develop ethical values from multiple sources but for help with dental ethical problems, 90 per cent of respondents would consult another dentist. CONCLUSIONS Of the ethical dilemmas discussed in this survey, those relating to poor quality treatment confronted most respondents. Also the actions of dentists in dealing with these dilemmas were most varied.
The Metabotropic Glutamate Receptor mGluR5 Induces Calcium Oscillations in Cultured Astrocytes via Protein Kinase C Phosphorylation

Abstract: The metabotropic glutamate receptor mGluR5, but not the closely related mGluR1, is expressed in cultured astrocytes, and this expression is up‐regulated by specific growth factors. We investigated the capability and underlying mechanisms of mGluR5 to induce oscillatory responses of intracellular calcium concentration ([Ca2+]i) in cultured rat astrocytes. Single‐cell [Ca2+]i recordings indicated that an mGluR‐selective agonist, (1S,3R)‐1‐aminocyclopentane‐1,3‐dicarboxylate (1S,3R‐ACPD), elicits [Ca2+]i oscillations in good agreement with the growth factor‐induced up‐regulation of mGluR5 in cultured astrocytes. A protein kinase C (PKC) inhibitor, bisindolylmaleimide I, converted a 1S,3R‐ACPD‐mediated oscillatory response into a nonoscillatory response. In addition, the PKC activator phorbol 12‐myristate 13‐acetate completely abolished the [Ca2+]i increase. These and other pharmacological properties of 1S,3R‐ACPD‐induced [Ca2+]i oscillations correlate well with those of the cloned mGluR5 characterized in heterologous expression systems. Furthermore, the potential involvement of protein phosphatases in [Ca2+]i oscillations is suggested. The present study demonstrates that mGluR5 is capable of inducing [Ca2+]i oscillations in cultured astrocytes and that phosphorylation/dephosphorylation of mGluR5 is critical in [Ca2+]i oscillations, analogous to the cloned mGluR5 expressed in heterologous cell lines.
Analysis and characterization of device variations in an LSI chip using an integrated device matrix array

For future large-scale integration design technology, the device matrix array (DMA), which precisely evaluates within-die variation in device parameters, has been developed. The DMA consists of a 14-by-14 array of common units. The unit size is 240 by 240 /spl mu/m, and each unit contains 148 measurement elements (52 transistors, 30 capacitors, 51 resistors, and 15 ring oscillators). The element selection and precise measurement are achieved with low parasitic resistance measurement buses and leakage-controlled switching circuits, which allow the measurement accuracy for a transistor, resistor, or capacitor of 90 pA, 11 m/spl Omega/, and 23 aF, respectively, in the 3/spl sigma/ range. The ability to obtain 29 008 samples from a chip enables statistical analysis of the variation in 148 elements of each chip with 240-/spl mu/m spatial resolution. This high resolution and large sample number allows us to precisely decompose the data into systematic and random variation parts with newly developed fourth-order polynomial fitting. Our methodology has been verified using a test chip fabricated by a 130-nm CMOS process with a 100-nm physical gate length and five Cu interconnect layers. In MOSFETs, the random part was dominant and indicated a certain /spl sigma/ value in every chip. In the case of the interconnect layers, the random and systematic parts of the resistance and the capacitance indicated variance fluctuations. By chip, by item, by size, by structure, random or systematic, the /spl sigma/ values of each variation show inconsistency which we believe is attributable to the Cu process. The correlation coefficients of systematic part between device element and ring oscillator frequency shown very high value (0.87-0.98), and those of a random part were low enough (-0.10-0.22) to prove the accuracy of decomposition.
Metabolic Syndrome in Small Fiber Sensory Neuropathy

Objectives: To determine the prevalence and risk of metabolic syndrome in patients with small fiber sensory neuropathy (SFSN). Methods: We searched our skin biopsy database and identified 194 subjects for this retrospective study. Of these 194 subjects, 43 had normal skin biopsies and 151 had mild, moderate, or severe length-dependent SFSN with no large fiber involvement. Fifty-four subjects had diabetic or prediabetic SFSN and 97 had idiopathic SFSN. Results: The mean age of the neuropathy group was older (54.1 ± 11.9 years) than the normal biopsy group (44.8 ± 13.0, P < 0.001). The prevalence of metabolic syndrome was higher in the neuropathy group (27.8%) than in the normal biopsy group (2.3%, P < 0.001). Age was not different among three neuropathy subgroups. The prevalence of metabolic syndrome was higher in the severe (38.1%) than in the moderate (26.0%) and mild (14.7%) neuropathy groups (P = 0.04). Multivariate analysis revealed that age (odds ratio [OR], 1.95; P < 0.001), metabolic syndrome (OR, 3.20; P < 0.001), hypertension (OR, 1.88; P = 0.04), and obesity (OR, 1.93; P = 0.004) were independent risk factors for SFSN. Conclusions: The prevalence of metabolic syndrome is increased in patients with SFSN and it correlates with the severity of SFSN. Metabolic syndrome may represent an independent risk factor for SFSN.
Real wages, profit margins and inflation in Turkish manufacturing under post-liberalization

This article reports investigations into the behaviour of gross profit margins (mark-ups) in Turkish manufacturing industries for the post-1980 liberalization period in relation to price inflation, trade liberalization (openness) and real wage costs. Panel data econometrics over 29 subsectors of Turkish manufacturing are used over the period 1980–1996. Results suggest that profit margins are positively and significantly related both to price inflation and real wage costs. However, openness is found to have very little impact on profit margins.
INTELLECTUAL CAPITAL CONFIGURATIONS AND VALUE CREATION : A CONCEPTUAL MODEL OF HR SHARED SERVICES Prepared for : The

The ways by which intellectual capital (IC) drives value creation is often limitedly understood, particularly in the case of Human Resource Shared Services (HRSS), as its components – human, organizational and social capital – are treated as independent and separate constructs. In this paper, a configuration approach to intellectual capital is adopted in order to develop a conceptual framework that provides an in-depth understanding of the ways in which intellectual capital creates value for HRSS end-users. We argue that the interrelationships among human, organisational and social capital form value-creating IC configurations which value creation capability is contingent upon the type of HR services offered. Through this, we contribute by explaining how intellectual capital drives value creation, and how HRSS may make use of their human, organisational and social capital to create value for their end-users.
Differential regulation of intracellular glucose metabolism by glucose and insulin in human muscle.

Insulin and glucose stimulate glucose uptake in human muscle by different mechanisms. Insulin has well-known effects on glucose transport, glycogen synthesis, and glucose oxidation, but the effects of hyperglycemia on the intracellular routing of glucose are less well characterized. We used euglycemic and hyperglycemic clamps with leg balance measurements to determine how hyperglycemia affects skeletal muscle glucose storage, glycolysis, and glucose oxidation in normal human subjects. Glycogen synthase (GS) and pyruvate dehydrogenase complex (PDHC) activities were determined using muscle biopsies. During basal insulin replacement, hyperglycemia (11.6 +/- 0.31 mM) increased leg muscle glucose uptake (0.522 +/- 0.129 vs. 0.261 +/- 0.071 mumol.min-1 x 100 ml leg tissue-1, P < 0.05), storage (0.159 +/- 0.082 vs. -0.061 +/- 0.055, P < 0.05), and oxidation (0.409 +/- 0.080 vs. 0.243 +/- 0.085, P < 0.05) compared with euglycemia (6.63 +/- 0.33 mM). The increase in basal glucose oxidation due to hyperglycemia was associated with increased muscle PDHC activity (0.499 +/- 0.087 vs. 0.276 +/- 0.049, P < 0.05). However, the increase in leg glucose storage was not accompanied by an increase in muscle GS activity. During hyperinsulinemia, hyperglycemia (11.9 +/- 0.49 mM) also caused an additional increase in leg glucose uptake over euglycemia (6.14 +/- 0.42 mM) alone (5.75 +/- 1.25 vs. 3.75 +/- 0.58 mumol.min-1 x 100 ml leg-1, P < 0.05). In this case the major intracellular effect of hyperglycemia was to increase glucose storage (5.03 +/- 1.16 vs. 2.39 +/- 0.37, P < 0.05). At hyperinsulinemia, hyperglycemia had no effect on muscle GS or PDHC activity. (ABSTRACT TRUNCATED AT 250 WORDS)
Comparison of Ocular Pulse Amplitude-Lowering Effects of Tafluprost and Latanoprost by Dynamic Contour Tonometry.

PURPOSE A prospective study was performed to compare the ocular pulse amplitude (OPA)-lowering effects of tafluprost and latanoprost, used in the treatment of glaucoma, using dynamic contour tonometry. METHODS The study population consisted of patients with normal-tension glaucoma (NTG) (n = 27) or primary open-angle glaucoma (POAG) (n = 14) treated with tafluprost and latanoprost. All patients were newly diagnosed with NTG and POAG and had undergone no previous treatment. Intraocular pressure (IOP) was measured by Goldmann applanation tonometry (GAT), OPA was measured by dynamic contour tonometry, and corrected OPA (cOPA) was calculated before and after 1 week, 1-3 months of treatment. RESULTS Initial IOP and OPA were 17.12 ± 3.75, 2.30 ± 0.56 mmHg and 17.53 ± 2.87, 2.65 ± 0.94 mmHg in the tafluprost and latanoprost groups, respectively. After 3 months of treatment, IOP and OPA were 13.00 ± 2.04 mmHg (24.1%) and 1.51 ± 0.30 mmHg (34.3%), respectively, in the tafluprost group. These values were 15.40 ± 2.32 mmHg (12.2%) and 2.08 ± 0.83 mmHg (21.5%), respectively, in the latanoprost group. Therefore, tafluprost significantly reduced IOP (P = 0.01), but OPA-lowering effects did not differ significantly between the 2 groups (P = 0.17). However, the cOPA-lowering effect of tafluprost (1.27 mmHg, 55.2%) was significantly greater than that of latanoprost (0.84 mmHg, 31.7%) after 3 months of treatment (P < 0.001). CONCLUSIONS Tafluprost and latanoprost, used to treat glaucoma, have marked OPA-lowering effects as well as IOP-lowering effects. Moreover, tafluprost has a greater effect than latanoprost. Therefore, it can be used for patients in need of IOP reduction and at risk of glaucoma progression.
Reduction of thyroid irradiation from 131-I by potassium iodide.

The prophylactic administration of 100 to 200 mg of potassium iodide in anticipation of radioactive iodine exposure will largely prevent uptake by the thyroid gland, thereby reducing the irradiation dose delivered by more than 98%. The same amount given at intervals after 131 I absorption is progressively less effective, but still reduces uptake to less than half after a delay of three hours. The suppressive effect of one dose is of short duration and daily readministration of the agent is required for prolonged protection. The extent of uptake blockade may be estimated by measuring serum inorganic iodide; concentrations of greater than 10μg /100 cc correlate with marked uptake arrest. Toxicity is negligible for a single ingestion, as is required in this temporary measure for the reduction of the immediate thyroid irradiation hazard, but the drug must be avoided by those allergic to it.
75–110-GHz $W$ -band High-Linearity Traveling-Wave T/R Switch by Using Negative Gate/Body-Biasing in 90-nm CMOS

In this letter, a 75–110-GHz W-band high-linearity traveling-wave single-pole-double-throw switch in 90-nm CMOS GUTM 1P9M is presented. Compared with the traditional traveling-wave switch with negative body-biasing technique, the proposed design applies the negative biasing to the gate terminals simultaneously. Therefore, the third-order intermodulation product is significantly reduced. The measured results show that the insertion loss is less than 3.4 dB, return loss is better than 10 dB, and Tx-to-Rx isolation is higher than 40 dB, respectively. For the linearity of the switch, the measured IP1dB is higher than 15 dBm and IIP3 is 37.1 dBm at 94 GHz, respectively. The proposed switch presents good performance of insertion loss, isolation, IP1dB, and IIP3, among the compared millimeter-wave CMOS switches.
Intracellular mechanisms underlying lipid accumulation (white opaque substance) in gastric epithelial neoplasms: A pilot study of expression profiles of lipid‐metabolism‐associated genes

White opaque substance (WOS) is a novel endoscopic finding in gastric neoplasms, indicating the intracellular accumulation of lipid droplets (LDs). However, gastric lipid metabolism has not been extensively investigated, even in normal mucosa. We investigated the expression profiles of lipid‐metabolism‐associated genes in gastric neoplasms.
Still No Evidence for a Photoreceptor-Level Abnormality in Dyslexia

In reply to Grosser and Spafford's (1992) defence of their theory that there is a photoreceptor-level abnormality in dyslexia we argue that (1) their original experiments do not tap rod functions, (2) the theory fails at the quantitative level, and (3) the proposition that rod inputs generate transient responses is false.
Why people see things that are not there: A novel Perception and Attention Deficit model for recurrent complex visual hallucinations

As many as two million people in the United Kingdom repeatedly see people, animals, and objects that have no objective reality. Hallucinations on the border of sleep, dementing illnesses, delirium, eye disease, and schizophrenia account for 90% of these. The remainder have rarer disorders. We review existing models of recurrent complex visual hallucinations (RCVH) in the awake person, including cortical irritation, cortical hyperexcitability and cortical release, top-down activation, misperception, dream intrusion, and interactive models. We provide evidence that these can neither fully account for the phenomenology of RCVH, nor for variations in the frequency of RCVH in different disorders. We propose a novel Perception and Attention Deficit (PAD) model for RCVH. A combination of impaired attentional binding and poor sensory activation of a correct proto-object, in conjunction with a relatively intact scene representation, bias perception to allow the intrusion of a hallucinatory proto-object into a scene perception. Incorporation of this image into a context-specific hallucinatory scene representation accounts for repetitive hallucinations. We suggest that these impairments are underpinned by disturbances in a lateral frontal cortex–ventral visual stream system. We show how the frequency of RCVH in different diseases is related to the coexistence of attentional and visual perceptual impairments; how attentional and perceptual processes can account for their phenomenology; and that diseases and other states with high rates of RCVH have cholinergic dysfunction in both frontal cortex and the ventral visual stream. Several tests of the model are indicated, together with a number of treatment options that it generates.
Sources of variation in the nesting behavior of chimpanzees (Pan troglodytes schweinfurthii) in the Budongo forest, Uganda

Data on nesting behavior and nests of the Sonso community of chimpanzees (Pan troglodytes schweinfurthii) living in the Budongo Forest, Uganda, were collected between October 1995 and December 1996. Analysis of the selection of nests shows a preference for particular tree species, especially Cynometra alexandri. Male chimpanzees nested lower than females. Day nests were found to be structurally simpler than night nests and were built in tree species used for feeding, at the same height as feeding activity. Day and night nests serve different functions, and should be clearly distinguished in studies of nesting behavior. Am. J. Primatol. 55:49–55, 2001. © 2001 Wiley‐Liss, Inc.
FIRST FAINT DUAL-FIELD OFF-AXIS OBSERVATIONS IN OPTICAL LONG BASELINE INTERFEROMETRY

Ground-based long baseline interferometers have long been limited in sensitivity in part by the short integration periods imposed by atmospheric turbulence. The first observation fainter than this limit was performed on 2011 January 22 when the Keck Interferometer observed a K = 11.5 target, about 1 mag fainter than its K = 10.3 atmospherically imposed limit; the currently demonstrated limit is K = 12.5. These observations were made possible by the Dual-Field Phase-Referencing (DFPR) instrument, part of the NSF-funded ASTrometry and phase-Referenced Astronomy project; integration times longer than the turbulence time scale are made possible by its ability to simultaneously measure the real-time effects of the atmosphere on a nearby bright guide star and correct for it on the faint target. We present the implementation of DFPR on the Keck Interferometer. Then, we detail its on-sky performance focusing on the accuracy of the turbulence correction and the resulting fringe contrast stability.