Miracle-dz/UniFAR-FTUs huggingface dataset:
Biodegradation, photooxidation and dissolution of petroleum compounds in an Arctic fjord during summer.

Increased economic activity in the Arctic may increase the risk of oil spills. Yet, little is known about the degradation of oil spills by solar radiation and the impact of nutrient limitation on oil biodegradation under Arctic conditions. We deployed adsorbents coated with thin oil films for up to 4 months in a fjord in SW Greenland to simulate and investigate in situ biodegradation and photooxidation of dispersed oil droplets. Oil compound depletion by dissolution, biodegradation and photooxidation was untangled by GC-MS-based oil fingerprinting. Biodegradation was limited by low nutrient concentrations, reaching 97% removal of nC13-26-alkanes only after 112 days. Sequencing of bacterial DNA showed the slow development of a bacterial biofilm on the oil films predominated by the known oil degrading bacteria Oleispira, Alkanindiges and Cycloclasticus. These taxa could be related to biodegradation of shorter-chain (≤C26) alkanes, longer-chain (≥C16) and branched alkanes, and polycyclic aromatic compounds (PACs), respectively. The combination of biodegradation, dissolution and photooxidation depleted most PACs at substantially faster rates than the biodegradation of alkanes. In Arctic fjords during summer, nutrient limitation may severely delay oil biodegradation, but in the photic zone, photolytic transformation of PACs may play an important role.
Cardiorespiratory fitness is associated with increased middle cerebral arterial compliance and decreased cerebral blood flow in young healthy adults: A pulsed ASL MRI study

Cardiorespiratory fitness is thought to have beneficial effects on systemic vascular health, in part, by decreasing arterial stiffness. However, in the absence of non-invasive methods, it remains unknown whether this effect extends to the cerebrovasculature. The present study uses a novel pulsed arterial spin labelling (pASL) technique to explore the relationship between cardiorespiratory fitness and arterial compliance of the middle cerebral arteries (MCAC). Other markers of cerebrovascular health, including resting cerebral blood flow (CBF) and cerebrovascular reactivity to CO2 (CVRCO2) were also investigated. Eleven healthy males aged 21 ± 2 years with varying levels of cardiorespiratory fitness (maximal oxygen uptake ( V · O2MAX) 38–76 ml/min/kg) underwent MRI scanning at 3 Tesla. Higher V · O2MAX was associated with greater MCAC (R2 = 0.64, p < 0.01) and lower resting grey matter CBF (R2 = 0.75, p < 0.01). However, V · O2MAX was not predictive of global grey matter BOLD-based CVR (R2 = 0.47, p = 0.17) or CBF-based CVR (R2 = 0.19, p = 0.21). The current experiment builds upon the established benefits of exercise on arterial compliance in the systemic vasculature, by showing that increased cardiorespiratory fitness is associated with greater cerebral arterial compliance in early adulthood.
Staging of Schizophrenia With the Use of PANSS: An International Multi-Center Study

Abstract Introduction A specific clinically relevant staging model for schizophrenia has not yet been developed. The aim of the current study was to evaluate the factor structure of the PANSS and develop such a staging method. Methods Twenty-nine centers from 25 countries contributed 2358 patients aged 37.21 ± 11.87 years with schizophrenia. Analysis of covariance, Exploratory Factor Analysis, Discriminant Function Analysis, and inspection of resultant plots were performed. Results Exploratory Factor Analysis returned 5 factors explaining 59% of the variance (positive, negative, excitement/hostility, depression/anxiety, and neurocognition). The staging model included 4 main stages with substages that were predominantly characterized by a single domain of symptoms (stage 1: positive; stages 2a and 2b: excitement/hostility; stage 3a and 3b: depression/anxiety; stage 4a and 4b: neurocognition). There were no differences between sexes. The Discriminant Function Analysis developed an algorithm that correctly classified >85% of patients. Discussion This study elaborates a 5-factor solution and a clinical staging method for patients with schizophrenia. It is the largest study to address these issues among patients who are more likely to remain affiliated with mental health services for prolonged periods of time.
Rate of non-response to ursodeoxycholic acid in a large real-world cohort of primary biliary cholangitis patients in Italy

Abstract Background and aim: Response to ursodeoxycholic acid (UDCA) is crucial for the prediction of primary biliary cholangitis (PBC) prognosis, and different response criteria were validated and proposed by reference centers for PBC. To date, rates of non-response to UDCA from real-world series are lacking. Methods: Hepatology/Gastroenterology centers belonging to ‘Club Epatologi Ospedalieri’ (CLEO) and ‘Associazione Italiana Gastroenterologi Ospedalieri’ (AIGO) were invited to participate in the study, and asked to extract all patients followed for PBC, without any selection or exclusion, and fill in the database provided. Results: Thirty-four centers were enrolled throughout Italy, for a total of 713 patients. None of these centers, except one, had a hepatology outpatient clinic devoted to the care of patients with autoimmune liver diseases. After excluding 79 cases of PBC/autoimmune hepatitis overlaps, 634 patients were analyzed: mean age, 64.4 ± 12.0 years; 91.2% females; F/M 10.3/1. For patients with at least 1 year of UDCA treatment (583), rates of non-response to UDCA were evaluated according to the Paris-I/-II, Toronto and GLOBE criteria, and compared with those in the original cohorts: 27% vs 39% in Paris-I cohort; 39.6% vs 52% in Paris-II; 20.1% vs 43.5% in Toronto; 15.7% vs 30% in GLOBE (age-specific cutoffs). Mean alkaline phosphatase levels on UDCA treatment, and the age-adjusted prevalence of F3/F4 fibrosis, appeared lower in this PBC population than in reference cohorts. Conclusions: A mean ∼15% better response to UDCA is observed in a real-world PBC population, probably due to migration of some of most severe/advanced cases to PBC referral centers.
The effect of telehealth interventions on quality of life of cancer survivors: A systematic review and meta-analysis

The objective of this study was to perform a systematic review and meta-analysis comparing the effect of telehealth interventions to usual care for cancer survivors’ quality of life. A comprehensive search of four different databases was conducted. Manuscripts were included if they assessed telehealth interventions and usual care for adult cancer survivors and reported a measure of quality of life. Pooled random effects models were used to calculate overall mean effects for quality of life pre- and post-intervention. Eleven articles fit all systematic review and meta-analysis criteria. Initial analyses indicated that telehealth interventions demonstrated large improvements compared with usual care in quality of life measures (Δ = 0.750, p = 0.007), albeit with substantial heterogeneity. Upon further analysis and outlier removal, telehealth interventions demonstrated significant improvements in quality of life compared with usual care (Δ = 0.141–0.144, p < 0.05). The results of the systematic review with meta-analysis indicate that supplementary interventions through telehealth may have a positive impact on quality of life compared with in-person usual care.
Limited Chemical Structural Diversity Found to Modulate Thyroid Hormone Receptor in the Tox21 Chemical Library

Background: Thyroid hormone receptors (TRs) are critical endocrine receptors that regulate a multitude of processes in adult and developing organisms, and thyroid hormone disruption is of high concern for neurodevelopmental and reproductive toxicities in particular. To date, only a small number of chemical classes have been identified as possible TR modulators, and the receptors appear highly selective with respect to the ligand structural diversity. Thus, the question of whether TRs are an important screening target for protection of human and wildlife health remains. Objective: Our goal was to evaluate the hypothesis that there is limited structural diversity among environmentally relevant chemicals capable of modulating TR activity via the collaborative interagency Tox21 project. Methods: We screened the Tox21 chemical library (8,305 unique structures) in a quantitative high-throughput, cell-based reporter gene assay for TR agonist or antagonist activity. Active compounds were further characterized using additional orthogonal assays, including mammalian one-hybrid assays, coactivator recruitment assays, and a high-throughput, fluorescent imaging, nuclear receptor translocation assay. Results: Known agonist reference chemicals were readily identified in the TR transactivation assay, but only a single novel, direct agonist was found, the pharmaceutical betamipron. Indirect activation of TR through activation of its heterodimer partner, the retinoid-X-receptor (RXR), was also readily detected by confirmation in an RXR agonist assay. Identifying antagonists with high confidence was a challenge with the presence of significant confounding cytotoxicity and other, non-TR-specific mechanisms common to the transactivation assays. Only three pharmaceuticals—mefenamic acid, diclazuril, and risarestat—were confirmed as antagonists. Discussion: The results support limited structural diversity for direct ligand effects on TR and imply that other potential target sites in the thyroid hormone axis should be a greater priority for bioactivity screening for thyroid axis disruptors. https://doi.org/10.1289/EHP5314
Personality structure in east and west Africa: Lexical studies of personality in Maa and Supyire-Senufo.

The field of psychology relies heavily on evidence from North America and Northern Europe. Universally applicable models require input from around the globe. Indigenous lexical studies of personality, which define the most salient person-descriptive concepts and their structure in a population, provide this. Such results are reported from two nonindustrialized communities, representing 2 of the 3 main language families of Africa, in groups with differing cultural characteristics. Maasai participants, traditionally herders in rural Kenya and Tanzania, have a highly structured, traditional culture. Supyire-Senufo participants are traditional horticulturalists in Mali. The 203 most common person-descriptive terms in Maasai were administered to 166 participants, who described 320 persons (166 highly regarded, 154 less so). The optimal emic solution included 5 factors: virtue/moral-character, debilitation/vulnerability, boldness/surgency, hubris/pride, and timidity. In the Maasai context, descriptions of well-regarded individuals were exceptionally uniform, suggesting the role of personality language in norm socialization in tight, traditional cultures. In Supyire, 115 participants used 208 person-descriptive terms to describe 227 targets (half highly regarded). The optimal emic solution included 10 factors: social self-regulation, well-being, vitality/resilience, broadmindedness, diligence versus laziness, madness, stubbornness versus attractiveness, acceptance versus discontent, hurry/worry, and peacefulness. The best convergence between the languages was at the 3-factor level, where factors relate to moral character, low agreeableness coupled with high extraversion, and emotional stability. Beginning with the 4-factor level, content related to local cultural characteristics became apparent. In both languages, 2-factor solutions matched the Big Two, but 3-, 5-, and 6-factor solutions failed to overlap with etic Pan-Cultural Three, Big Five, or Big Six models. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
Unravelling fatty liver haemorrhagic syndrome: 1. Oestrogen and inflammation

ABSTRACT Previous studies have implicated oestrogen as a factor in the induction of fatty liver haemorrhagic syndrome (FLHS). In this study, a refined laying hen model was employed to permit further investigations. Intramuscular (i.m.) injections of exogenous oestrogen as β-estradiol-17-dipropionate (E2) (5 mg/kg BW) were given every 4 days for 20 days to 30-week-old hens fed either ad libitum or with restricted feed intake. Elevated (P < 0.01) plasma oestrogen concentrations produced significant macroscopic and microscopic hepatic alterations. Hens in the E2-treated ad libitum fed (EAL) group experienced a higher incidence of FLHS than hens in the E2-treated restricted feed intake group, showing that birds with a higher feed intake are more at risk of developing FLHS. Histological examination of livers revealed that hens in the E2-treated ad libitum fed group had consistent and severe fat infiltration in the liver, and fat vacuolization within hepatocytes. Fat accumulation and fat droplets were found not only in the cytoplasm of hepatocytes but also in liver sinusoids. White blood cell counts and fibrinogen concentrations were altered (P < 0.01) in hens treated with E2 when compared with controls. Plasma fibrinogen concentrations were altered over time, and correlated with white blood cell counts (Pearson’s correlation r = 0.96; P = 0.001). Hens treated with E2 had increased (P < 0.01) levels of cholesterol and triglycerides, confirming that E2 induced hypercholesterolaemia and hypertriglyceridaemia. It was concluded that E2 successfully induced FLHS in hens, with typical systemic and hepatic events resulting from a disturbance in lipid metabolism and chronic low-grade inflammation.
Specific macrophage populations promote both cardiac scar deposition and subsequent resolution in adult zebrafish

Abstract Aims A robust inflammatory response to tissue injury is a necessary part of the repair process but the deposition of scar tissue is a direct downstream consequence of this response in many tissues including the heart. Adult zebrafish not only possess the capacity to regenerate lost cardiomyocytes but also to remodel and resolve an extracellular scar within tissues such as the heart, but this scar resolution process remains poorly understood. This study aims to characterize the scarring and inflammatory responses to cardiac damage in adult zebrafish in full and investigate the role of different inflammatory subsets specifically in scarring and scar removal. Methods and results Using stable transgenic lines, whole organ imaging and genetic and pharmacological interventions, we demonstrate that multiple inflammatory cell lineages respond to cardiac injury in adult zebrafish. In particular, macrophage subsets (tnfα+ and tnfα−) play prominent roles with manipulation of different phenotypes suggesting that pro-inflammatory (tnfα+) macrophages promote scar deposition following cardiac injury whereas tnfα− macrophages facilitate scar removal during regeneration. Detailed analysis of these specific macrophage subsets reveals crucial roles for Csf1ra in promoting pro-inflammatory macrophage-mediated scar deposition. Additionally, the multifunctional cytokine Osteopontin (Opn) (spp1) is important for initial scar deposition but also for resolution of the inflammatory response and in late-stage ventricular collagen remodelling. Conclusions This study demonstrates the importance of a correctly balanced inflammatory response to facilitate scar deposition during repair but also to allow subsequent scar resolution, and full cardiac regeneration, to occur. We have identified Opn as having both pro-fibrotic but also potentially pro-regenerative roles in the adult zebrafish heart, driving Collagen deposition but also controlling inflammatory cell resolution.
Exercise intensity regulates the effect of heat stress on substrate oxidation rates during exercise

Abstract Hyperthermia stimulates endogenous carbohydrate metabolism during exercise; however, it is not known if exercise intensity impacts the metabolic effect of heat stress. In the first study of this two-part investigation, endurance-trained male cyclists performed incremental exercise assessments in 18 and 35°C (60% rH). The stimulatory effect of heat stress on carbohydrate oxidation rates was greater at high vs. moderate vs. low relative intensity (P < 0.05). In agreement, no effects of heat stress on carbohydrate oxidation rates were observed during 60-min of subsequent low-intensity cycling. In study two, endurance-trained male cyclists performed 20-min of moderate-intensity (power at the first ventilatory threshold) and 5-min of high-intensity (power at the second ventilatory threshold) cycling in 18, 28, 34, and 40°C (60% rH). At moderate-intensity, carbohydrate oxidation rates were significantly elevated by heat stress in 40°C (P < 0.05), whereas at high-intensity carbohydrate oxidation rates were significantly elevated by heat stress in 34 and 40°C (P < 0.05). This exercise intensity-mediated regulation of the effect of heat stress on carbohydrate oxidation may be partially attributable to observed plasma adrenaline responses. Our data suggest that under moderate environmental heat stress (34–35°C, 60% rH), heat stress-induced changes in CHO oxidation rates are unlikely to occur unless the relative exercise intensity is high (81 ± 8%⩒O2max), whereas under more extreme environmental heat stress (40°C, 60% rH), these changes occur at lower relative intensities (69 ± 8%⩒O2max). This provides indication of when heat stress-induced metabolic changes during exercise are likely to occur.
Marketing Strategies of SMEs and Performance: Empirical Evidence from Pharmaceutical Sector of Khyber Pakhtunkhwa

The study finds the effects of marketing strategies on the SME performance. Further, it explores the marketing strategies adopted by the pharmaceutical companies in various industrial sectors of KP. The Industrial Estate Hayatabad, Industrial Estate Hattar and Industrial Estate Gadoon were taken as sample areas for the selection of firms. Data was collected from 300 pharmaceutical firms in these Industrial Estates. Closedended questionnaire was used to collect data. The segmentation strategy, differentiation strategy, cost leadership strategy i.e. porter generic strategies were analyzed. The study used the correlation and regression model. Results reveal the cost leadership, differentiation strategy, segmentation have positive relationship with the firm performance. The findings also show that the cost leadership and differentiation strategy have significant effect while the segmentation strategy has insignificant effect on the performance of a firm.
Understanding, predicting, and tuning the fragility of vitrimeric polymers

Significance The intricate interplay between the molecular structure of a material and its emergent macroscopic dynamics lies at the heart of modern materials science. This interplay, however, remains notoriously poorly understood for glass-forming systems. The recent advent of vitrimers—a promising new class of recyclable high-performance polymers with anomalous glass-forming properties—revives the urgency to gain a full understanding of the elusive structure–dynamics link in glassy matter. We combine computer simulations and first-principles theory to rationally expose the structural origins of the complex glassy dynamics in vitrimers. Our findings provide cues for a better fundamental understanding of glass formation and may stimulate the development of sustainable amorphous materials with on-demand functionalities. Fragility is an empirical property that describes how abruptly a glass-forming material solidifies upon supercooling. The degree of fragility carries important implications for the functionality and processability of a material, as well as for our fundamental understanding of the glass transition. However, the microstructural properties underlying fragility still remain poorly understood. Here, we explain the microstructure–fragility link in vitrimeric networks, a novel type of high-performance polymers with unique bond-swapping functionality and unusual glass-forming behavior. Our results are gained from coarse-grained computer simulations and first-principles mode-coupling theory (MCT) of star-polymer vitrimers. We first demonstrate that the vitrimer fragility can be tuned over an unprecedentedly broad range, from fragile to strong and even superstrong behavior, by decreasing the bulk density. Remarkably, this entire phenomenology can be reproduced by microscopic MCT, thus challenging the conventional belief that existing first-principles theories cannot account for nonfragile behaviors. Our MCT analysis allows us to rationally identify the microstructural origin of the fragile-to-superstrong crossover, which is rooted in the sensitivity of the static structure factor to temperature variations. On the molecular scale, this behavior stems from a change in dominant length scales, switching from repulsive excluded-volume interactions to intrachain attractions as the vitrimer density decreases. Finally, we develop a simplified schematic MCT model which corroborates our microscopically founded conclusions and which unites our findings with earlier MCT studies. Our work sheds additional light on the elusive structure–fragility link in glass-forming matter and provides a first-principles–based platform for designing amorphous materials with an on-demand dynamic response.
Signatures of an eccentric disc cavity: Dust and gas in IRS 48

We test the hypothesis that the disc cavity in the ‘transition disc’ Oph IRS 48 is carved by an unseen binary companion. We use 3D dust–gas smoothed-particle hydrodynamics simulations to demonstrate that marginally coupled dust grains concentrate in the gas overdensity that forms in the cavity around a low binary mass ratio binary. This produces high contrast ratio dust asymmetries at the cavity edge similar to those observed in the disc around IRS 48 and other transition discs. This structure was previously assumed to be a vortex. However, we show that the observed velocity map of IRS 48 displays a peculiar asymmetry that is not predicted by the vortex hypothesis. We show the unusual kinematics are naturally explained by the non-Keplerian flow of gas in an eccentric circumbinary cavity. We further show that perturbations observed in the isovelocity curves of IRS 48 may be explained as the product of the dynamical interaction between the companion and the disc. The presence of an ∼0.4 M⊙ companion at an ∼10 au separation can qualitatively explain these observations. High spatial resolution line and continuum imaging should be able to confirm this hypothesis.
Large Intelligent Surface for Positioning in Millimeter Wave MIMO Systems

Millimeter-wave (mmWave) multiple-input multiple-output (MIMO) system for the fifth generation (5G) cellular communications can also enable single-anchor positioning and object tracking due to its large bandwidth and inherently high angular resolution. In this paper, we introduce the newly invented concept, large intelligent surface (LIS), to mmWave positioning systems, study the theoretical performance bounds (i.e., Cramér-Rao lower bounds) for positioning, and evaluate the impact of the number of LIS elements and the value of phase shifters on the position estimation accuracy compared to the conventional scheme with one direct link and one non-line-of-sight path. It is verified that better performance can be achieved with a LIS from the theoretical analyses and numerical study.