Miracle-dz/UniFAR-FTUs huggingface dataset:
The use of computed tomography when comparing nickel-titanium and stainless steel files during preparation of simulated curved canals.

AIM The aim of this study was to compare canal preparations completed with Hedstrom and K-files of ISO size 15 - 40, made of nickel-titanium (Ni-Ti) and stainless steel (SS). METHODOLOGY Eighty simulated canals with 200 and 30 degrees C curvatures were prepared using the step-back technique and quarter turn/pull instrument manipulation. Middle and apical level canal sections were taken using computed tomography. RESULTS No significant difference was found between any of the file types at either level with respect to canal curvature (20 degrees or 30 degrees). At the middle level, the stainless steel files caused more enlargement toward the inner part, compared to nickel-titanium files. At the apical level, nickel-titanium canal files caused more enlargement toward the inner part, whereas more outward enlargement was caused by stainless steel instruments. No significant difference could be observed at the middle level (P > 0.05) related to the enlargement toward the outer side of the canal curvature. Transportation at both levels was significantly less (P < 0.001) for the Ni-Ti files than the SS ones. Centring ratios of the file types at the middle level were low, but not significantly different (P > 0.05), whereas at the apical level the centring ratios were significantly higher for the Ni-Ti files (P < 0.001). CONCLUSIONS Ni-Ti instruments produced preparations with adequate enlargement, less transportation, and a better centring ratio.
The first 10,000 Adult Attachment Interviews: distributions of adult attachment representations in clinical and non-clinical groups

More than 200 adult attachment representation studies, presenting more than 10,500 Adult Attachment Interview (AAI; George, Kaplan, & Main, 1985) classifications, have been conducted in the past 25 years. In a series of analyses on the distributions of the AAI classifications in various cultural and age groups, fathers, and high-risk and clinical samples, we used the distribution of the combined samples of North American non-clinical mothers (23% dismissing, 58% secure, 19% preoccupied attachment representations, and 18% additionally coded for unresolved loss or other trauma) to examine deviations from this normative pattern, through multinomial tests and analyses of correspondence. The analyses were restricted to AAI classifications coded according to the Main, Goldwyn, and Hesse (2003) system. We did not find gender differences in the use of dismissing versus preoccupied attachment strategies, and the AAI distributions were largely independent of language and country of origin. Clinical subjects showed more insecure and unresolved attachment representations than the norm groups. Disorders with an internalizing dimension (e.g., borderline personality disorders) were associated with more preoccupied and unresolved attachments, whereas disorders with an externalizing dimension (e.g., antisocial personality disorders) displayed more dismissing as well as preoccupied attachments. Depressive symptomatology was associated with insecurity but not with unresolved loss or trauma, whereas adults with abuse experiences or PTSD were mostly unresolved. In order to find more reliable associations with clinical symptoms and disorders, future AAI studies may make more fruitful use of continuous AAI scales in addition to the conventionally used categorical classifications.
A 12‐week randomised study comparing intravenous iron sucrose versus oral ferrous sulphate for treatment of postpartum anemia

Objective. To analyze the effect of intravenous ferrous sucrose compared with oral ferrous sulphate on hematological parameters and quality of life in women with postpartum anemia. Design. Open randomised controlled trial. Setting. Multicentre study comprising five obstetrical departments in Norway. Population. Hundred and twenty‐eight postpartum women with hemorrhagic anemia (Hb between 6.5 g/100 ml and 8.5 g/100 ml). The intervention group (59 women) received 600 mg iron sucrose intravenously followed by 200 mg iron sulphate daily from week 5. The control group (70 women) were given 200 mg iron sulphate daily. Methods. Randomisation and start of treatment occurred within 48 hours of the delivery. Participants were followed up at 4, 8 and 12 weeks. Main outcome measures. Hemoglobin, ferritin and quality of life assessed with the Medical Outcomes Study Short Form 36 (SF‐36) and the Fatigue Scale. Results. After 4 weeks the mean hemoglobin values in both groups were similar (11.9g/100ml vs. 12.3g/100ml, p = 0.89). The mean serum ferritin value after 4 weeks was significantly higher in the intervention group with 13. 7μg/L vs. 4. 2μg/L in the control group (p<0.001). At 8 and 12 weeks the hematological parameters were similar. The total fatigue score was significantly improved in the intervention group at week 4, 8 and 12, whereas SF‐36 scores did not differ. Conclusion. Women who received 600mg intravenous iron sucrose followed by standard oral iron after four weeks, replenished their iron stores more rapidly and had a more favorable development of the fatigue score indicating improved quality of life.
Comparison of lateral condensation and thermomechanically compacted warm alpha-phase gutta-percha with a single cone for obturating curved root canals.

OBJECTIVE To evaluate and compare the sealability and radiographic quality of root fillings in extracted teeth by using lateral condensation of gutta-percha or alpha-phase gutta-percha in conjunction with a single gutta-percha cone. STUDY DESIGN A total of 108 single-rooted teeth were divided into 2 groups of 54 teeth based on canal shape. Canals were prepared to a minimum 0.055 taper and enlarged to a size 35 at the working distance. Irrigation was done with 17% EDTA and 2.5% sodium hypochlorite (NaOCl) to remove smear layer. One group was obturated by using cold lateral condensation of gutta-percha; the other group was obturated with thermomechanically compacted alpha-phase gutta-percha and a single cone of gutta-percha. Apical extrusion of sealer or gutta-percha was recorded. Sealability of each technique was assessed by dye penetration. The radiographic quality of obturation was also determined. RESULTS Root canals filled with alpha-phase gutta-percha and a single cone had significantly more extrusion of sealer than canals filled by lateral condensation. Lateral condensation achieved significantly better scores for radiographic quality. There was no significant difference between the 2 filling techniques in terms of apical or coronal leakage. CONCLUSIONS Thermomechanically condensed alpha-phase gutta-percha used in conjunction with a single gutta-percha cone had poorer radiographic quality than laterally condensed gutta-percha.
The Serengeti food web: empirical quantification and analysis of topological changes under increasing human impact.

1. To address effects of land use and human overexploitation on wildlife populations, it is essential to better understand how human activities have changed species composition, diversity and functioning. Theoretical studies modelled how network properties change under human-induced, non-random species loss. However, we lack data on realistic species-loss sequences in threatened, real-world food webs to parameterize these models. 2. Here, we present a first size-structured topological food web of one of the most pristine terrestrial ecosystems in the world, the Serengeti ecosystem (Tanzania). The food web consists of 95 grouped nodes and includes both invertebrates and vertebrates ranging from body masses between 10(-7) and 10(4) kg. 3. We study the topological changes in this food web that result from the simulated IUCN-based species-loss sequence representing current species vulnerability to human disturbances in and around this savanna ecosystem. We then compare this realistic extinction scenario with other extinction sequences based on body size and connectance and perform an analysis of robustness of this savanna food web. 4. We demonstrate that real-world species loss in this case starts with the biggest (mega) herbivores and top predators, causing higher predator-prey mass ratios. However, unlike theoretically modelled linear species deletion sequences, this causes poor-connected species to be lost first, while more highly connected species become lost as human impact progresses. This food web shows high robustness to decreasing body size and increasing connectance deletion sequences compared with a high sensitivity to the decreasing connectance deletion scenario. 5. Furthermore, based on the current knowledge of the Serengeti ecosystem, we discuss how the focus on food web topology alone, disregarding nontrophic interactions, may lead to an underestimation of human impacts on wildlife communities, with the number of trophic links affected by a factor of two. 6. This study underlines the importance of integrative efforts between the development of food web theory and basic field work approaches in the quantification of the structure of interaction networks to sustain natural ecosystems in a changing world.
Effect of type 2 diabetes predisposing genetic variants on colorectal cancer risk.

BACKGROUND The link between colorectal cancer (CRC) and type 2 diabetes mellitus (T2D) has been extensively studied. Although it is commonly accepted that T2D is a risk factor for CRC, the underlying mechanisms are still poorly understood. RESEARCH DESIGN AND METHODS Given that the genetic background contributes to both traits, it is conceivable that genetic variants associated with T2D may also influence the risk of CRC. We selected 26 T2D-related single-nucleotide polymorphisms (SNP) previously identified by genome-wide association studies and assessed their association with CRC and their interaction with known risk factors (gender, T2D, and body mass index) of CRC. Selected SNP were genotyped in 1798 CRC cases and 1810 controls from the population-based Darmkrebs: Chancen der Verhütung durch Screening (DACHS) study (Germany). RESULTS Patients carrying the TCF7L2_rs7903146_T allele had an increased risk of CRC (P(trend) = 0.02), whereas patients harboring the IL13_rs20541_T allele had a reduced risk (P(trend) = 0.02). A further analysis revealed gender-specific effects: the TCF7L2_rs7903146_T allele was associated with an increased risk of CRC in women (P(trend) = 0.003) but not in men (P(interaction) = 0.06); the LTA_rs1041981_A allele was associated with a decreased risk for CRC in women (P(trend) = 0.02), with an opposite effect in men (P(trend) = 0.05; P(interaction) = 0.002); the CDKAL1_rs7754840_C allele was associated with a decreased risk for CRC in men (P(trend) = 0.03), with no effect in women (P(interaction) = 0.03). The risk associated with the presence of T2D was modified both by IGF2BP2_rs4402960 and PPARγ_rs1801282 SNP (P(interaction) = 0.04 and 0.04, respectively). None of the findings were significant after correction for multiple comparisons. CONCLUSIONS These findings suggest that T2D-related variants modify CRC risk independently and/or in an interactive manner according to the gender and the presence or absence of T2D.
Improved Method of Producing Human Neural Progenitor Cells of High Purity and in Large Quantities from Pluripotent Stem Cells for Transplantation Studies

Transplantation of human neural progenitor cells (hNPCs) is a promising therapeutic approach for various diseases of the central nervous system (CNS). Reliable testing of hNPC transplantation in animal models of neurological diseases requires that these cells can be produced in sufficient amounts, show consistent homogeneity as a neural cell population, and be reliably labeled for in vivo tracking. In addition, the cells should be characterized as being at the optimal state of differentiation favoring successful engraftment. Here, we show that high numbers of purified hNPCs can be produced from human embryonic stem cells (hESCs) by manually selecting specifically sized and shaped spheres followed by fluorescence-activated cell sorting based on the relative cell size. In addition, we report that labeling of hNPCs with ultra-small superparamagnetic iron oxide (USPIO) particles does not affect the cellular morphology or growth. More importantly, we show that the transduction with lentiviral vector encoding green fluorescent protein (GFP) decreases the neurality of the cell population. We conclude that our cost-effective protocol of generating hNPCs is widely applicable for preclinical studies on CNS disorders. This improved method of producing large quantities of high-purity hNPCs maybe useful also when generating hNPCs from human induced pluripotent stem (hiPS) cell lines. However, caution should be used when lenti-GFP transduction is applied for hNPC labeling.
On circularity

Circularity is an assumption that was originally introduced for the definition of the probability distribution function of complex normal vectors. However, this concept can be extended in various ways for nonnormal vectors. The first purpose of the paper is to introduce and compare some possible definitions of circularity. From these definitions, it is also possible to introduce the concept of circular signals and to study whether or not the spectral representation of stationary signals introduces circular components. Therefore, the relationships between circularity and stationarity are analyzed in detail. Finally, the theory of linear mean square estimation for complex signals exhibits some connections with circularity, and it is shown that without this assumption, the estimation theory must be reformulated. >
ersistence of MODIS evapotranspiration impacts from mountain pine eetle outbreaks in lodgepole pine forests , south-central Rocky ountains

The current extent and high severity (percent tree mortality) of mountain pine beetle outbreaks across western North America has been attributed to regional climate change, specifically warmer summer and winter temperatures and drier summers. This study paired multiple mountain pine beetle outbreak location datasets, both current and historical, with Moderate Resolution Imaging Spectroradiometer (MODIS) and Global Modeling and Assimilation Office (GMAO) Modern Era Retrospective-Analysis for Research and Applications (MERRA) products in order to quantify the full seasonal evapotranspiration impact of outbreak events for decades after outbreak (0 to 60 years). Following mountain pine beetle outbreaks in lodgepole pine (Pinus contorta) stands in the Colorado Rockies we observed an 18.7 ± 1.4% (p < 0.01) reduction in the rate of summer evapotranspiration at 14 to 20 years since outbreak. We also observed a 21.6 ± 2.2% (p < 0.01) increase in the rate of summer evapotranspiration, relative to non-attacked stands, in intermediate-aged stands 30 to 40 years since outbreak. Changes to growing season evapotranspiration correlated positively with changes in stand density, stand leaf area index (LAI) and the fraction of absorbed photosynthetically active radiation (fPAR), while high incoming solar radiation during the summer months acted to amplify changes to evapotranspiration even given relatively minor changes to summer fPAR and LAI due to the rapid regeneration of understory vegetation. Lodgepole pine mortality from mountain pine beetle outbreaks showed lasting effects on stand-scale evapotranspiration which could have important implications for regional water resources.
A Companion to The Cantos of Ezra Pound

The Companion is a major contribution to the literary evaluation of Pound's great, but often bewildering and abstruse work, The Cantos. Available in a one-volume paperback edition for the first time, the Companion brings together in conveniently numbered glosses for each canto the most pertinent details from the vast body of work on the Cantos during the last thirty years. The Companion contains 10,421 separate glosses that include translations from eight languages, identification of all proper names and works, Pound's literary and historical allusions, and other exotica, with exegeses based upon Pound's sources. Also included is a supplementary bibliography of works on Pound, newly updated, and an alphabetized index to The Cantos.
Culture in salutogenesis : the scholarship of Aaron

Aaron Antonovsky wrote extensively, although disjointedly, about the roles of culture in salutogenesis. This paper provides a synopsis of his work in this arena. A literature review identified those of his English language writings in which culture was a subject, and relevant text segments were analysed using an inductive followed by a deductive method. Using thematic network analysis, text segments were sorted inductively by open coding and then analysed. This was followed by deductive text segment coding guided by the constructs of the salutogenic model of health. The analysis revealed that Antonovsky had an expansive interest in the roles of culture in salutogenesis. His writings included attention to the role of culture in: (a) shaping life situations; (b) giving rise to stressors and resources; (c) contributing to life experiences of predictability, load balance and meaningful roles; (d) facilitating the development of the sense of coherence and (e) shaping perceptions of health and well-being. Antonovsky’s writings about culture were sometimes conjectural, as well as being obviously influenced by his life experience in the USA and then in Israel, and by the spirit of the times in which he lived. However, he also drew extensively on his own and others’ empiricism, leading him to view culture as an integral aspect of the salutogenic model of health. The present analysis provides salutogenesis scholars with a roadmap of Antonovsky’s reflections, ponderings and conclusions about culture in the context of salutogenesis. It provides assistance in the form of an overview of Antonovsky’s treatment of culture in the context of salutogenesis. (Global Health Promotion, 2014; 21(4): 16–23)
Exploiting the buccal mucosa as an alternative route for the delivery of donepezil hydrochloride.

The potential of the buccal mucosa as an alternative route for the systemic delivery of donepezil (DPZ) hydrochloride, and the impact of various skin penetration enhancers on DPZ buccal permeability, was assessed using an in vitro model. DPZ was applied to porcine buccal mucosa in modified Ussing chambers either alone (20 μg/mL) or with different treatment protocols of various enhancers including Azone® (AZ), deoxycholic acid (DA), polyethylene glycol (PEG) 400, and oleic acid (OA)-PEG 400. DPZ permeated the buccal mucosa very rapidly with a permeability coefficient of 35.6 ± 4.9 × 10(-6) cm/s, which was not significantly affected by AZ pretreatment. Coapplication of DA 0.6% (w/w), but not DA 0.01% (w/w), reduced the buccal permeation of DPZ (3.5-fold), and PEG 400 reduced the absorption of DPZ in a dose-dependent manner (1.6- and 18.0-fold reduction at 5% and 50%, w/w, PEG 400, respectively). Coapplication of a combination of OA 1% (v/w) and PEG 400 5% (w/w) further reduced DPZ permeability (5.5-fold), which was demonstrated to result from excipient-induced DPZ precipitation as assessed by light microscopy analysis. These results confirm the feasibility of a novel buccal delivery system for Alzheimer's disease, and suggest various approaches that may be exploited for controlled buccal delivery of DPZ.
Using Remote Sensing and Geographic Information Systems to Study Urban Quality of Life and Urban Forest Amenities

This study examines urban quality of life by assessing the relationship between observed socioeconomic conditions and urban forest amenities in Terre Haute, Indiana, USA. Using remote-sensing methods and techniques, and ordinary least squares regression, the paper determines the relationship between urban leaf area and a population density parameter with median income and median housing value. Results demonstrate positive correlations between urban leaf area, population density, and their interaction with median income and median housing value. Furthermore, leaf area, density, and their interaction statistically account for observed variance in median income and median housing value, indicating that these variables may be used to study observed quality-of-life metrics. The methods used in this study may be useful to city managers, planners, and foresters who are concerned with urban quality-of-life issues, and who are interested in developing and implementing alternative policy assessment regimes.
Patients attitudes towards experience with use of generics in Slovakia, performance of generic substitution.

BACKGROUND Generic substitution of branded pharmaceuticals is a widely adopted tool among payers to achieve cost savings. The adoption and safe use of generics among consumers is predicated upon their knowledge of and attitudes toward these products. OBJECTIVES The aims of this study were to assess patients' attitudes towards generic drugs and their experience with using generics, identify factors associated with differences in attitudes and/or experience, and discern the rate of generic substitution in Slovakia. METHODS Two thousand questionnaires were distributed to patients via pharmacies throughout Slovakia by eleven pharmaceutical companies representing GENAS (the Slovak Generic Association). Responses were received from 1,777 persons (88.85% response rate). Demographic information of respondents was also acquired. RESULTS Only 33.8% (600/1773) of respondents care to know about the product which they are using. Over one half (61.1%, 1084/1774) of respondents indicated no distrust in using generics, with many of them indicating a preference for a product with a lower co-payment. CONCLUSION About 1/3 of patients care to know whether they are using generic or branded pharmaceuticals. If there is a lack of information about generics, this could inhibit the use of generics by patients and discern a rate of generic substitution (Tab. 3, Fig. 1, Ref. 18).
CHD7 mutations are not a major cause of atrioventricular septal and conotruncal heart defects

Since 2004, CHD7 mutations have been a known cause of CHARGE (Coloboma, Heart defects, Atresia of choane, Retardation of growth and development, Genital hypoplasia, Ear anomalies) syndrome, but the full clinical spectrum of CHD7 mutations is only now gradually emerging. CHD7 mutations have been identified in patients who do not fulfill the clinical criteria for CHARGE syndrome and in patients with overlapping syndromes. Variable congenital heart defects occur in the majority of patients with CHD7 mutations, with an overrepresentation of atrioventricular septal defects and conotruncal heart defects. This prompted us to study CHD7 in 46 patients with these heart defects and one other feature of CHARGE syndrome. We identified two CHD7 variants that were inherited from a healthy parent (c.3778 + 17C > T, c.7294G > A), but no pathogenic CHD7 mutations. We conclude that CHD7 mutations are not a major cause of the atrioventricular septal defects and conotruncal heart defects, not even if one extra phenotypic feature of CHARGE syndrome is present. Therefore, CHD7 analysis should not be performed routinely in this group of patients. However, we do recommend adding CHD7 to massive parallel sequencing gene panels for diagnostic work in patients with syndromic heart defects. © 2014 Wiley Periodicals, Inc.
Modeling Situations in Neural Chat Bots

Social media accumulates vast amounts of online conversations that enable data-driven modeling of chat dialogues. It is, however, still hard to utilize the neural network-based S EQ 2S EQ model for dialogue modeling in spite of its acknowledged success in machine translation. The main challenge comes from the high degrees of freedom of outputs (responses). This paper presents neural conversational models that have general mechanisms for handling a variety of situations that affect our responses. Response selection tests on massive dialogue data we have collected from Twitter conﬁrmed the effectiveness of the proposed models with situations derived from utterances, users or time.