Miracle-dz/UniFAR-FTUs huggingface dataset:
‘Fish’ (Actinopterygii and Elasmobranchii) diversification patterns through deep time

Actinopterygii (ray‐finned fishes) and Elasmobranchii (sharks, skates and rays) represent more than half of today's vertebrate taxic diversity (approximately 33000 species) and form the largest component of vertebrate diversity in extant aquatic ecosystems. Yet, patterns of ‘fish’ evolutionary history remain insufficiently understood and previous studies generally treated each group independently mainly because of their contrasting fossil record composition and corresponding sampling strategies. Because direct reading of palaeodiversity curves is affected by several biases affecting the fossil record, analytical approaches are needed to correct for these biases. In this review, we propose a comprehensive analysis based on comparison of large data sets related to competing phylogenies (including all Recent and fossil taxa) and the fossil record for both groups during the Mesozoic–Cainozoic interval. This approach provides information on the ‘fish’ fossil record quality and on the corrected ‘fish’ deep‐time phylogenetic palaeodiversity signals, with special emphasis on diversification events. Because taxonomic information is preserved after analytical treatment, identified palaeodiversity events are considered both quantitatively and qualitatively and put within corresponding palaeoenvironmental and biological settings. Results indicate a better fossil record quality for elasmobranchs due to their microfossil‐like fossil distribution and their very low diversity in freshwater systems, whereas freshwater actinopterygians are diverse in this realm with lower preservation potential. Several important diversification events are identified at familial and generic levels for elasmobranchs, and marine and freshwater actinopterygians, namely in the Early–Middle Jurassic (elasmobranchs), Late Jurassic (actinopterygians), Early Cretaceous (elasmobranchs, freshwater actinopterygians), Cenomanian (all groups) and the Paleocene–Eocene interval (all groups), the latter two representing the two most exceptional radiations among vertebrates. For each of these events along with the Cretaceous‐Paleogene extinction, we provide an in‐depth review of the taxa involved and factors that may have influenced the diversity patterns observed. Among these, palaeotemperatures, sea‐levels, ocean circulation and productivity as well as continent fragmentation and environment heterogeneity (reef environments) are parameters that largely impacted on ‘fish’ evolutionary history, along with other biotic constraints.
Multiwall carbon nano‐onions induce DNA damage and apoptosis in human umbilical vein endothelial cells

Growing evidence has indicated the potential adverse effects on cardiovascular system of some nanomaterials, including fullerenes. In this study, we have evaluated the biological effects of multiwall carbon nano‐onions (MWCNOs) (average size of 31.2 nm, ζ potential of 1.6 mV) on human umbilical vein endothelial cells (HUVECs). It was found that MWCNOs exhibited a dose‐dependent inhibitory effect on cell growth; EC50 was 44.12 μg/mL. Thus, three concentrations were chosen (0.2, 1, and 5 μg/mL) for further experiments. Flow cytometry analysis revealed that 1 and 5 μg/mL MWCNOs could induce apoptosis in HUVECs, the apoptotic rates were 12% and 24% at 24 h after exposure. On the other hand, MWCNOs did not affect the cell cycle distribution during 24 h period. Using γH2AX foci formation as an indicator for DNA damage, it was shown that 5 μg/mL MWCNOs can induce γH2AX foci formation in HUVECs at 6, 12, and 24 h after treatment, whereas 0.2 μg/mL MWCNOs induced γH2AX foci formation only at 6 h after treatment. In addition, all three concentrations of MWCNOs induced the generation of reactive oxygen species (ROS), and inhibition of ROS generation can partially decrease the γH2AX foci formation induced by MWCNOs. Taken together, these data first suggested that MWCNOs can induce DNA damage and apoptosis in HUVECs, and that ROS might be involved in this process. © 2011 Wiley Periodicals, Inc. Environ Toxicol 28: 442–450, 2013.
Interest Rate Channel and Real Economy in Nigeria: A Bayesian Vector Autoregression Approach

This study examined the dynamic response of real economy to interest rate shocks using Bayesian vector autoregression model with Minnesota/Litterman prior criterion. Impulse Response Functions showed that all the variables were consistent with the theory apart from investment whose response was counter intuitive. Forecast Error Variance Decomposition confirmed theoretical interactions between Monetary Policy Rate through interest rate and inflation. Interest rate channel under this framework is effective to bring the economy to stability by suppressing inflation rate and bring it to normalcy in Nigeria with adverse effect on growth rate of Gross Domestic Product due to necessary and policy conflicts.
"Moving Forward": Success from a Physiotherapist's Point of View.

PURPOSE The purpose of this study was to capture the meaning of professional success to experienced physiotherapists practising in the Greater Toronto Area (GTA). METHODS Using a qualitative, phenomenological approach, 10 physiotherapists from the GTA each participated in a 60-minute, semistructured, face-to-face interview. Interviews were transcribed verbatim and analyzed using the vanKaam method, modified by Moustakas. RESULTS Participants described success as "moving forward," a dynamic and evolving experience that extends throughout an entire career. Study participants identified three markers of professional success: positive patient outcome, career advancement, and advancement of the physiotherapy profession. The experience of moving forward toward success applied to all of these markers and was driven by making choices. Choices made throughout a career were influenced by mentorship and self-reflection. CONCLUSIONS The physiotherapists in this study described different indicators of success than have been described by other health care or corporate professionals in the literature. Success in the physiotherapy profession is experienced as a circular rather than linear process. Physiotherapists, professional organizations, and employers have a role in fostering professional success. We suggest the introduction of mentorship and self-reflection programmes early in one's career, focusing on the three markers of success: patient outcomes, career advancement, and advancement of the profession.
Nomograms for predicting local recurrence, distant metastases, and overall survival for patients with locally advanced rectal cancer on the basis of European randomized clinical trials.

PURPOSE The purpose of this study was to develop accurate models and nomograms to predict local recurrence, distant metastases, and survival for patients with locally advanced rectal cancer treated with long-course chemoradiotherapy (CRT) followed by surgery and to allow for a selection of patients who may benefit most from postoperative adjuvant chemotherapy and close follow-up. PATIENTS AND METHODS All data (N = 2,795) from five major European clinical trials for rectal cancer were pooled and used to perform an extensive survival analysis and to develop multivariate nomograms based on Cox regression. Data from one trial was used as an external validation set. The variables used in the analysis were sex, age, clinical tumor stage stage, tumor location, radiotherapy dose, concurrent and adjuvant chemotherapy, surgery procedure, and pTNM stage. Model performance was evaluated by the concordance index (c-index). Risk group stratification was proposed for the nomograms. RESULTS The nomograms are able to predict events with a c-index for external validation of local recurrence (LR; 0.68), distant metastases (DM; 0.73), and overall survival (OS; 0.70). Pathologic staging is essential for accurate prediction of long-term outcome. Both preoperative CRT and adjuvant chemotherapy have an added value when predicting LR, DM, and OS rates. The stratification in risk groups allows significant distinction between Kaplan-Meier curves for outcome. CONCLUSION The easy-to-use nomograms can predict LR, DM, and OS over a 5-year period after surgery. They may be used as decision support tools in future trials by using the three defined risk groups to select patients for postoperative chemotherapy and close follow-up (http://www.predictcancer.org).
Bioengineering the Lung : Molecules , Materials , Matrix , Morphology , and Mechanics Ventilation-induced lung injury is not exacerbated by growth restriction in preterm lambs

X Beth J. Allison, Stuart B. Hooper, Elise Coia, Valerie A. Zahra, Graham Jenkin, Atul Malhotra, Arvind Sehgal, Martin Kluckow, Andrew W. Gill, Foula Sozo, Suzanne L. Miller, and Graeme R. Polglase The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria, Australia; Department of Obstetrics and Gynecology, Monash University, Clayton, Victoria, Australia; Monash Newborn, Monash Medical Centre, and Department of Pediatrics, Monash University, Melbourne, Victoria, Australia; Department of Neonatology, Royal North Shore Hospital and University of Sydney, Sydney, New South Wales, Australia; Centre for Neonatal Research and Education, The University of Western Australia, Western Australia, Australia; and Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia
Active Portfolio Management with Conditioning Information

In this article, the authors propose more efficient and practical portfolio management methodology in which portfolio weights are determined by several market observations. Their method is based on the managed portfolio construction technique and makes it more tractable for fund managers. The key points of this work are as follows: (i) the authors impose constraints on active weights against to the pre-specified benchmark weights, and (ii) the authors show empirically that the constraints stabilize and improve the portfolio performance by backtests. TOPICS: Portfolio management/multi-asset allocation, performance measurement
Blunted feedback processing during risky decision making in adolescents with a parental history of substance use disorders

Abstract Risky decision making, a hallmark phenotype of substance use disorders (SUD), is thought to be associated with deficient feedback processing. Whether these aberrations are present prior to SUD onset or reflect merely a consequence of chronic substance use on the brain remains unclear. The present study investigated whether blunted feedback processing during risky decision making reflects a biological predisposition to SUD. We assessed event-related potentials elicited by positive and negative feedback during performance of a modified version of the Balloon Analogue Risk Task (BART) among high-risk adolescents with a parental history of SUD (HR; n = 61) and normal-risk controls (NR; n = 91). HR males made significantly more risky and faster decisions during the BART than did NR controls. Moreover, HR adolescents showed significantly reduced P300 amplitudes in response to both positive and negative feedback as compared to NR controls. These differences were not secondary to prolonged substance use exposure. Results are discussed in terms of feedback-specific processes. Reduced P300 amplitudes in the BART may reflect poor processing of feedback at the level of overall salience, which may keep people from effectively predicting the probability of future gains and losses. Though conclusions are tentative, blunted feedback processing during risky decision making may represent a promising endophenotypic vulnerability marker for SUD.
Performance of an interferon-gamma release assay for diagnosing latent tuberculosis infection in children

SUMMARY Newly developed interferon-gamma release assays have become commercially available to detect tuberculosis (TB) infection in adults. However, little is known about their performance in children. We compared test results between the QuantiFERON-TB® Gold test (QFT) and tuberculin skin test (TST) in young children living with pulmonary TB patients in Cambodia. Of 195 children tested with both QFT and TST, the TST-positive rate of 24% was significantly higher than the QFT-positive rate of 17%. The agreement between the test results was considerable (κ-coefficient 0·63). Positive rates increased from 6% to 32% for QFT and from 15% to 43% for TST, according to the sputum smear grades of the index cases. The presence of Bacille Calmette-Guérin (BCG) scars did not significantly affect the results of TST or QFT in a logistic regression analysis. In conclusion, QFT can be a substitute for TST in detecting latent TB infection in childhood contacts aged ⩽5 years, especially in those who may have a false-positive TST due to BCG vaccination or non-tuberculous mycobacterial infection.
A Qualitative Study of Physician Perspectives on Prognostication in Neonatal Hypoxic Ischemic Encephalopathy

Hypoxic ischemic encephalopathy is the most frequent cause of neonatal encephalopathy and yields a great degree of morbidity and mortality. From an ethical and clinical standpoint, neurological prognosis is fundamental in the care of neonates with hypoxic ischemic encephalopathy. This qualitative study explores physician perspectives about neurological prognosis in neonatal hypoxic ischemic encephalopathy. This study aimed, through semistructured interviews with neonatologists and pediatric neurologists, to understand the practice of prognostication. Qualitative thematic content analysis was used for data analysis. The authors report 2 main findings: (1) neurological prognosis remains fundamental to quality-of-life predictions and considerations of best interest, and (2) magnetic resonance imaging is presented to parents with a greater degree of certainty than actually exists. Further research is needed to explore both the parental perspective and, prospectively, the impact of different clinical approaches and styles to prognostication for neonatal hypoxic ischemic encephalopathy.
Nexus of Institutional Quality and Stock Market Development: Long-Run Relationships in Dynamic Heterogeneous Panel

INTRODUCTION Muhammad Saeed Meo1 Ramzan Ali2 Bilal Aziz Poswal3 1The Superior College, Lahore, Pakistan Email: saeedk8khan@gmail.com 2The University of Lahore. 3The University of Lahore. 4University of the Punjab. The current study has been carried out to analyze the nexus between stock market development and institutional quality (quality of governance). The term governance is used here to refer to the institutional actions that deal with the regularization of financial institutions in an economy. Evidence has however demonstrated that governess and securities exchange execution is fairly indivisible; along these lines recommending they both go parri-passu. An improvement in institutions which are responsible for the administration of stock market is the base of stock market development. According to Aggarwal et al. (2005) it is evident from an ample body of research that countries with insignificant legal and corporate administration system usually attract lower investment. As exposed by Hooper et al. (2009) agency and transaction costs, which are the major issues, can be alleviated through improved and enhanced quality of governance, which will alternatively lead to significant increase in shareholders return. Further, it is evident from the stock market analysis that countries and firms with an effective level of governance get a relatively high stock market rating. Similarly, countries that practice standard governance system are observed having a relatively high price market ranking. Moreover, after the financial crises, reports of countries with poor and volatile stock market showed that corporate governance practices are abused in countries that have poor governance sceneries. JEL Classification: G11, G15, G18
Continuous Ambulatory Peritoneal Dialysis is Better than Automated Peritoneal Dialysis as First-Line Treatment in Renal Replacement Therapy

This article examines the roles of continuous ambulatory peritoneal dialysis (CAPD) versus automated peritoneal dialysis (APD) as first-line renal replacement therapy. To date, no high-quality large-scale randomized controlled studies have compared CAPD with APD as first-line therapy. However, a discussion on this issue is important so that nephrologists can decide and patients can have a choice of modality on which to start dialysis, especially in the context of health care economics. We review the literature and present Hong Kong as the model of a “CAPD first” policy, an appealing, cost-effective approach for any country. An ideal renal replacement therapy should provide optimal survival, lowest possible risk for comorbidity, highest level of quality of life, and equally important, acceptable cost to society. When we consider this subject in the context that all patients should be started on one first-line modality, the data suggest that a “CAPD first” policy has all these advantages, with APD probably having the edge only with regard to patient preference. The present review highlights preservation of residual renal function, removal and balancing of sodium, incidence of peritonitis, peritoneal membrane transport status, patient rehabilitation, and financial issues in demonstrating that a “CAPD first” policy is the model that should be adopted.
Bendamustine, lenalidomide, and dexamethasone (BRD) is highly effective with durable responses in relapsed multiple myeloma

Bendamustine is a multifunctional alkylating agent with single agent activity in myeloma. We designed the current phase 1/2 trial to determine the maximum tolerated doses (MTD) of bendamustine that can be safely combined with lenalidomide and dexamethasone and to assess the safety and efficacy of the combination. Patients with relapsed MM following at least 1 prior therapy, but no more than four lines of prior therapy and with measurable disease were enrolled. Bendamustine 75 mg/m2 given on days 1 and 2, lenalidomide 25 mg given days 1–21 and dexamethasone 40 mg on days 1, 8, 15, and 22, was the recommended Phase 2 dose. Seventy‐one patients were accrued: 21 on Phase 1 and 50 on Phase 2. The median age was 62.3 years; patients had a median of three prior lines of therapy (range 1–4), with over 70% of the patients having received prior lenalidomide, bortezomib, and/or peripheral blood stem cell transplant. Thirty‐four of 70 (49%) patients had a confirmed partial response or better, including 20 patients (29%) with a very good partial response or better. An additional 4 patients had a minor response, translating to an overall 55% clinical benefit rate. Grade 3 or higher toxicity was seen in 96% of patients, with ≥grade 3 hematologic in 94% and nonhematologic in 50%. The median progression free survival was 11.8 months and the median duration of response was 23 months. The combination of bendamustine, lenalidomide, and dexamethasone is very effective in relapsed multiple myeloma with high response rates and durable responses Am. J. Hematol. 90:1106–1110, 2015. © 2015 Wiley Periodicals, Inc.
Volume-Outcome Relationship in Surgical Interventions for Spinal Metastases

Background: Surgery for spinal metastases is challenging and carries a high risk of perioperative morbidity and mortality. Procedures with such characteristics often exhibit a volume-outcome relationship. This has not been previously characterized for spinal metastasis surgery to our knowledge. Methods: The Florida State Inpatient Database (2011 through 2014) was queried to identify patients who had undergone surgery for spinal metastases. Surgeon and hospital surgical volumes were compared with 90-day complication and readmission rates to develop procedural cut-points used to define high and low-volume providers. These were included in a multivariable logistic regression analysis that was adjusted for confounders. A separate analysis was performed to evaluate the effect of race/ethnicity and insurance status on the likelihood of receiving care from a high-volume surgeon or hospital. Results: This study included 3,135 patients treated by 1,488 surgeons at 162 hospitals. Patients treated at low-volume hospitals had significantly higher odds of having postoperative complications (odds ratio [OR] = 1.47; 95% confidence interval [CI] = 1.13, 1.91) and readmissions (OR = 1.36; 95% CI = 1.06, 1.75). Those treated by low-volume surgeons also demonstrated a higher likelihood of complications (OR = 1.40; 95% CI = 1.16, 1.69) and readmissions (OR = 1.38; 95% CI = 1.17, 1.62). The likelihood of receiving intervention from a high-volume surgeon was significantly lower for African Americans (OR = 0.55; 95% CI = 0.41, 0.75) and Hispanics (OR = 0.60; 95% CI = 0.44, 0.83). The odds of being treated at a high-volume hospital were also significantly lower for African Americans (OR = 0.58; 95% CI = 0.40, 0.84) and Hispanics (OR = 0.28; 95% CI = 0.20, 0.38). Conclusions: There is a clear relationship between the volume and outcomes of surgical treatment of spinal metastases, with high-volume providers demonstrating reduced complication and readmission rates. Racial and ethnic minorities appear to experience health-care segregation when it comes to surgical care for spinal metastases. Regionalization of care for these conditions may help improve access to high-volume providers and mitigate disparities in care. Level of Evidence: Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Supporting Hard Real-time Communication of Periodic Messages over Switched Ethernet

Nowadays, switched Ethernet is considered as an attractive enabling technology for supporting industrial communication needs. However, because of some disadvantages, switched Ethernet requires some mechanisms for supporting real-time communication, which is the most important challenge in industrial communication. This paper suggests and proves the schedulability condition for hard real-time periodic messages on a switched Ethernet that are scheduled under EDF-based scheduling algorithm without any modification of original switches, thus they can be applied directly to industrial communication. The switched Ethernet operates based on the master-slaves principles and the synchronized model, and the transmission of real-time periodic messages will be handled by master node to fulfil their hard real-time requirements.
Remittances and the Dutch Disease: Evidence from Panel Data for 18 Developing Countries

ABSTRACT In this paper, using the GMM technique we attempt to empirically investigate the Dutch disease effect of remittances. The analyses are based on an annual balanced panel data set for 18 developing countries, which have remittances to GDP ratio of 5 percent and above, over the years 1999–2015. It is found that an inflow of remittances has a positive effect on economic growth, whereas it leads to a depreciation of the real effective exchange rate.