Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevalence and Impact of De Novo Donor‐Specific Antibodies During a Multicenter Immunosuppression Withdrawal Trial in Adult Liver Transplant Recipients

The development of human leukocyte antigen (HLA) donor‐specific antibody/antibodies (DSA) is not well described in liver transplant (LT) patients undergoing immunosuppression (IS) withdrawal protocols despite the allograft risk associated with de novo DSA (dnDSA). We analyzed the development of dnDSA in 69 LT patients who received calcineurin inhibitor monotherapy and were enrolled in the ITN030ST study. Of these 69 patients, 40 stable patients were randomized to IS maintenance (n = 9) or IS minimization (n = 31). Nine of the 31 IS minimization patients achieved complete withdrawal and were free of IS. Among patients who achieved stable IS monotherapy 1 year after transplantation, the prevalence of dnDSA was 18.8%. Acute rejections and the biopsy‐proven findings disqualifying patients from IS withdrawal attempt were factors associated with dnDSA development (P = 0.011 and P = 0.041, respectively). Among randomized patients, dnDSA prevalence was 51.7% after IS minimization and 66.7% in IS‐free patients. dnDSA prevalence in patients on IS maintenance was 44.4%. dnDSA development during IS minimization was a risk factor for acute rejection (P = 0.015). The majority of dnDSA were against HLA‐DQ antigens (78.7%). Conclusion. During the first year following transplantation, acute rejections increase the risk of developing dnDSA, so dnDSA positivity should be considered for IS withdrawal eligibility; during IS minimization, dnDSA development was associated with acute rejection, which prevented further IS withdrawal attempts.
Online signature verification using i-vector representation

Signature verification (SV) is one of the common methods for identity verification in banking, where for security reasons, it is very important to have an accurate method for automatic SV (ASV). ASV is usually addressed by comparing the test signature with the enrolment signature(s) signed by the individual whose identity is claimed in two manners: online and offline. In this study, a new method based on the i-vector is proposed for online SV. In the proposed method, a fixed-length vector, called i-vector, is extracted from each signature and then this vector is used for template making. Several techniques such as nuisance attribute projection (NAP) and within-class covariance normalisation (WCCN) are also investigated in order to reduce the intra-class variation in the i-vector space. In the scoring and decision making stage, they also propose to apply a 2-class support vector machine method. Experimental results show the proposed method could achieve 8.75% equal error rate (EER) on SigWiComp2013 database in the best case. On SVC2004 database, it also achieved 5% EER that means 11% relative improvement compared with the best reported result. In addition to its considerable accuracy gain, it has shown significant improvement in the computational cost over conventional dynamic time warping method.
School choice, space and the geography of marketization- Analyses of educational restructuring in upper secondary education in Sweden

Title: School choice, space and the geography of marketization. Analyses of educational restructuring in upper secondary education in Sweden Author: Anna-Maria Fjellman Language: English with a Swedish summary ISBN: 978-91-7346-985-2 (print) ISBN: 978-91-7346-986-9 (pdf) ISSN: 0436-1121
Do Narcissists Enjoy Visiting Social Networking Sites? It Depends on How Adaptive They Are

Previous evidence suggests that narcissistic people tend to visit social networking sites (SNS) frequently, but the emotions accompanying their engagement on such sites has not been a significant subject of study. Therefore, we examined the relationship between narcissism and the affective experience on SNS in two different samples. To do so, we not only examined narcissism as a whole but also distinguished between adaptive and maladaptive narcissism. Results of the two studies consistently showed that: (1) narcissism as a whole was not correlated with the SNS affective experience; (2) maladaptive narcissism was predictive of a worse affective experience on SNS; and (3) partly due to a positive correlation with self-esteem, adaptive narcissism was associated with a better SNS affective experience. In addition, these findings held with SNS activities considered in simultaneity. The present research extends our understanding of the relationship between narcissism and social networking as well as that between emotion and social networking.
Lead I R‐wave amplitude to differentiate idiopathic ventricular arrhythmias with left bundle branch block right inferior axis originating from the left versus right ventricular outflow tract

Differentiation of right versus left ventricular outflow tract (RVOT vs. LVOT) arrhythmia origin with left bundle branch block right inferior axis (LBRI) morphology is relevant to ablation planning and risk discussion. Our aim was to determine if lead I R‐wave amplitude is useful for differentiation of RVOT from LVOT arrhythmias with LBRI morphology.
Durable Clinical Responses and Long-Term Follow-Up of Stage III–IV Non-Small-Cell Lung Cancer (NSCLC) Patients Treated With IDO Peptide Vaccine in a Phase I Study—A Brief Research Report

Background: Long-term follow-up on a clinical trial of 15 stage III-IV NSCLC patients treated with an Indoleamine 2,3-Dioxygenase (IDO) peptide vaccine (NCT01219348). Methods: Fifteen HLA-A2-positive patients with stable stage III-IV NSCLC after standard chemotherapy were treated with subcutaneous vaccinations (100 μg IDO5 peptide, sequence ALLEIASCL, formulated in 900 μl Montanide) biweekly for 2.5 months and thereafter monthly until progression or up to 5 years. Here we report long-term clinical follow-up, toxicity and immunity. Results: Three of 15 patients are still alive corresponding to a 6-year overall survival of 20 %. Two patients continued monthly vaccinations for 5 years (56 vaccines). One of the two patients developed a partial response (PR) of target lesions in the liver 15 months after the first vaccine and has remained in PR ever since. The other patient had a solitary distant metastasis in a lymph node in retroperitoneum at baseline which normalized during treatment. All following evaluation scans during the treatment have been tumor free. The vaccine was well tolerated for all 5 years with no long-term toxicities registered. The third long-term surviving patient discontinued vaccinations after 11 months due to disease progression. Flow cytometry analyses of PBMCs from the two long-term responders demonstrated stable CD8+ and CD4+ T-cell populations during treatment. In addition, presence of IDO-specific T-cells was detected by IFN-γ Elispot in both patients at several time points during treatment. Conclusion: IDO peptide vaccination was well tolerated for administration up to 5years. Two of 15 patients are long-term responders with ongoing clinical response 6 years after 1st vaccination.
Comparison of Scapular Manipulation With External Rotation Method of Reduction of Acute Anterior Shoulder Dislocation for Sedation Requirements and Success Rates.

BACKGROUND Anterior shoulder dislocation is a common sports-related musculoskeletal injury. Various methods have been described for reduction of the dislocation. A method that requires less sedation without compromising the success rate is likely to be highly useful in austere and prehospital settings. This study compares scapular manipulation with external rotation method for requirement of sedation and success rates. METHODS Forty-six patients with anterior shoulder dislocation were allocated alternatively to reduction using either scapular manipulation (SMM) or external rotation (ERM) techniques. The groups were compared for sedation requirements, pain scores, and success rates. RESULTS Reductions using SMM had fewer requirements for sedation (13% versus 39%; p < .05) and higher first-pass success rates (87% versus 61%; p < .05) as compared with ERM for anterior shoulder dislocation reduction. The numeric rating score of pain during reduction procedures was less in SMM (mean, 1.65 [standard deviation, 1.6]) than in ERM group (mean, 4.30 [standard deviation, 1.8]; p < .01). CONCLUSION The SMM required less sedation and had higher first-pass success rates than ERM for reduction of anterior shoulder dislocation. The SMM is thus likely to be of advantage in resource-limited austere settings.
Combination of EGFR Inhibitor Lapatinib and MET Inhibitor Foretinib Inhibits Migration of Triple Negative Breast Cancer Cell Lines

Triple-negative breast cancer (TNBC) is the most challenging subtype to treat due to the lack of estrogen receptor, progesterone receptor, and HER2 expression, which excludes the usage of directed targeted therapy against them. Promising therapeutic targets are the hepatocyte growth factor receptor (MET) and epidermal growth factor receptor (EGFR), which expression is frequently elevated in TNBC. Inhibitors of these receptors used as monotherapy are often ineffective. Due to that, we studied the efficacy of combined therapy targeting MET and EGFR simultaneously. Two TNBC cell lines were treated with lapatinib (a dual EGFR and HER2 inhibitor), foretinib (a MET inhibitor), or a combination of the two. After the inhibitors treatment, we verified the cell viability (XTT assay), distribution of the cell cycle phases, the activation of signaling pathways (Western blotting), distribution of invadopodia, fluorescent gelatin digestion (immunofluorescence), and the invasion capacity of cells. A combination of foretinib and lapatinib effectively reduced the viability of examined cells, led to G2/M arrest and reduction of pAKT. There was also a decreasein number of invadopodia formed by cells, their ability to digest gelatin and reduction of cells migration/invasion capacity. Therapy targeting of both EGFR and MET receptors was much more effective against tested cells than monotherapy. We selected a combination of drugs that could be successfully used against this breast cancer subtype.
Tc17/IL-17A Up-Regulated the Expression of MMP-9 via NF-κB Pathway in Nasal Epithelial Cells of Patients With Chronic Rhinosinusitis

Chronic rhinosinusitis (CRS) is a common chronic inflammatory disease of the upper airways involving nasal cavity and sinus. Deriving both from its clinical complexity with protean clinical manifestations as well its pathogenetic heterogeneity, the molecular mechanisms contributing to the pathogenesis of CRS remain unclear, and attract a wide interest in the field. Current evidences indicate that IL-17A is highly expressed in chronic rhinosinusitis with nasal polyps (CRSwNP). However, its pathogenetic role in regulation of tissue remodeling of CRSwNP remains unknown. The present study aimed to investigate the cellular origins and functions of IL-17A cytokine in CRSwNP, and further determined whether IL-17A could affect the expression of metalloproteinases (MMPs), the remodeling factors of CRSwNP. The results showed that the expression of IL-17A was upregulated in nasal tissues of patients with CRSwNP compared to those with chronic rhinosinusitis without nasal polyps (CRSsNP) and controls. CD8+ cytotoxic T lymphocytes (Tc) were major IL-17A producers in nasal tissues of CRSwNP. Interleukin (IL)-17-producing CD8+ T cells (Tc17) was significantly higher in nasal tissues of CRSwNP than CRSsNP and controls. Nonetheless, no difference was observed among the IL-17A in peripheral blood lymphocytes of these three groups. Moreover, in the same patients, IL-17A expression was negligible in lymphocytes of peripheral blood when compared with nasal tissues. Increased gene and protein expression of MMP-7 and MMP-9 in patients with CRSwNP compared with controls were observed. In CRSwNP samples, IL-17A receptor (IL-17AR) co-localized with MMP-9 and they were mainly expressed in the epithelial cells. MMP-9 expression was up-regulated both in Primary human nasal epithelial cells (PHNECs) and a nasal epithelial cell line (RPMI 2650) by IL-17A treatment, and diminished by anti-IL-17AR treatment. Furthermore, IL-17A promoted the expression of MMP-9 by activating the NF-κB signal pathway. Thus, our results have revealed a crucial role of IL-17A and Tc cells on pathogenesis and tissue remodeling of CRSwNP.
A Critical Review of Proactive Detection of Driver Stress Levels Based on Multimodal Measurements

Stress is a major concern in daily life, as it imposes significant and growing health and economic costs on society every year. Stress and driving are a dangerous combination and can lead to life-threatening situations, evidenced by the large number of road traffic crashes that occur every year due to driver stress. In addition, the rate of general health issues caused by work-related chronic stress in drivers who work in public and private transport is greater than in many other occupational groups. An in-vehicle warning system for driver stress levels is needed to continuously predict dangerous driving situations and proactively alert drivers to ensure safe and comfortable driving. As a result of the recent developments in ambient intelligence, such as sensing technologies, pervasive devices, context recognition, and communications, driver stress can be automatically detected using multimodal measurements. This critical review investigates the state of the art of techniques and achievements for automatic driver stress level detection based on multimodal sensors and data. In this work, the most widely used data followed by frequent and highly performed selected features to detect driver stress levels are analyzed and presented. This review also discusses key methodological issues and gaps that hinder the implementation of driver stress detection systems and offers insights into future research directions.
Curious users of casual creators

Casual creators are a type of design tool identified by Compton & Mateas, characterised by an orientation towards enjoyable, intrinsically motivated creative exploration, rather than task-oriented designer productivity. In our experiments holding rapid game jams with Wevva, a casual creator for mobile game design, we have noticed, however, that users seem to vary considerably even within the context of using a casual creator. Some people focus on designing specific games, while others explore the design space extensively, or even focus exclusively on prodding the edges of the design space looking for its possibilities and limits. We hypothesise that the latter group of users is driven primarily by curiosity about a casual creator and its design space. This results in different patterns of behaviour to the former group (of design-oriented users), which may worth characterising and perhaps explicitly designing for.
Embedding invertible languages with binders: a case of the FliPpr language

This paper describes a new embedding technique of invertible programming languages, through the case of the FliPpr language. Embedded languages have the advantage of inheriting host languages' features and supports; and one of the influential methods of embedding is the tagless-final style, which enables a high level of programmability and extensibility. However, it is not straightforward to apply the method to the family of invertible/reversible/bidirectional languages, due to the different ways functions in such domains are represented. We consider FliPpr, an invertible pretty-printing system, as a representative of such languages, and show that Atkey et al.'s unembedding technique can be used to address the problem. Together with a reformulation of FliPpr, our embedding achieves a high level of interoperability with the host language Haskell, which is not found in any other invertible languages. We implement the idea and demonstrate the benefits of the approach with examples.
Practical Linguistic Annotation: The Hebrew Bible

Annotation and research in the humanities are tightly coupled. Annotations can be seen as expressions of research activity which can be turned into input data for subsequent research. The digital paradigm has profoundly altered the ways in which we humans can handle the information content of our sources and it also affects the practice of annotation. We explore new ways of annotation that were not feasible before the digital times, and we list a few requirements for annotation to act as a reliable source of research information. Rather than conducting an academic discussion on the ontology of annotations, we highlight practical use cases for new kinds of annotations. We illustrate those in a concrete system for linguistic annotations to the Hebrew Bible, SHEBANQ.
Evaluation of the effect of diode laser for debonding ceramic brackets on nanomechanical properties of enamel

Background: The heat from laser can lead to the destruction of organic components of enamel and consequently changes in the mechanical properties of enamel. The purpose of this study was to evaluate the effect of diode laser on the nanomechanical properties of enamel in the process of debonding the ceramic brackets. Materials and Methods: In This in vitro study Eighteen ceramic brackets were bonded on the intact premolars in 3 groups of 6 (one control and two study groups). To debond the brackets in the study groups, laser diode was used for 3 s with 1W and 3W power. Shear bond strength and adhesive remnant index were recorded for all groups. Hardness and elastic modulus were measured in 1–31 μ depth from enamel surface in each debonded area. Analysis of variance was used for determining the difference in shear bond strength (SBS), hardness, and elastic modulus and was followed by post hoc Tukey's honest significant difference test. One-sample t-test was used to compare the changes in the pulp temperature with the standard threshold (5.5°C). The significance level was set at %5 in this study. Results: SBS was significantly greater in the control group compared to the study groups. There was no significant difference in the average of hardness and elastic modulus of enamel between the groups. Pulp temperature elevation in the study groups was significantly < 5.5°C (P = 0.000). Conclusion: The diode laser with either 1W or 3W power for 3 s is effective in debonding the ceramic brackets without any detrimental effect on the pulp or mechanical properties of enamel. In regard to the pulp health, the 1W power laser is rather recommended for debonding the ceramic brackets than the 3W laser power.
A high-level petri net-based formal model of distributed self-adaptive systems

Engineering complex distributed self-adaptive systems is a challenging task due to multiple interacting distributed components that monitor and adapt the managed parts operating in a dynamic environment. Therefore, formal methods able to specify and analyze the behavior of decentralized adaptation control by multiple interacting MAPE-K (Monitor, Analyze, Plan, and Execute over a shared Knowledge) components are highly demanded. In this paper we introduce a formal framework for modeling and analyzing self-adaptive systems with decentralized adaptation control. The framework makes use of High-Level Petri nets which represents a sound and expressive formal model for distributed discrete-event systems. We show how to specify in a natural way structural changes that are likely to occur in adaptable and evolvable distributed applications. Our approach supports validation and verification activities to check correctness of the MAPE components. As a proof-of-concepts, we show how to use our framework to model and analyze a self-optimizing cluster management system.
Investigating potential mediator between statin and coronary artery calcification

Statins are mainstay anti-lipidaemic treatments for preventing cardiovascular diseases but also known to increase coronary artery calcification (CAC). However, underlying relationship between statin and CAC is still unclear. This study explored the mediating role of five statin-related biochemical factors [i.e., low-density lipoprotein (LDL)-cholesterol, high-density lipoprotein (HDL)-cholesterol, triglyceride, glucose, and high sensitivity C-reactive protein levels]. Seoul Metabolic Syndrome cohort study includes 1370 participants suspected of metabolic syndrome. For causal mediation analysis, the dataset for 2016 including 847 participants with coronary computed tomography without any missing value were analysed using the Mediation package in R software. This study identified a causal mediation mechanism of HDL-cholesterol among the five biochemical factors. It implied that statin treatment increases the HDL-cholesterol level, leading to decreasing the probability of CAC score > 0. Estimated values of interest in HDL-cholesterol mediation were (1) average causal mediation effect, -0.011 with 95% CI [-0.025, -0.003], (2) average direct effect, 0.143 with 95% CI [0.074, 0.219], and total effect, 0.132 with 95% CI [0.063, 0.209]. Its mediation effect was maintained regardless of statin intensity. Sensitivity analysis also provided a robustness of the results under potential existence of a confounder between HDL-cholesterol and CAC. This study suggests a potential causal pathway between statin and CAC (the positive association of statin on CAC) through HDL-cholesterol as an inhibitor.
Peak Load Cutting in District Heating Network

Simulations of different peak load cutting scenarios in district heating of buildings were performed. Decrease in percentages of 30%, 50%, and 70% in peak loads was analyzed for the two modelled apartment buildings. Simulation results show that even 70% peak load cuts are possible in individual buildings. However, results also reveal that for some buildings 30% peak load cuts would require compromising with the indoor temperature. Therefore, it is important to take into account the different heat storing capacities available in each of the buildings. In future, systems with multiple buildings will be studied to effectively utilize individual heat storing capacities to cut city level peak loads. Simulations presented in this article show that better energy efficiency in district heating can be achieved by predicting the energy consumption and utilizing the thermal mass of a building.
Protective Effects of Oleuropein Against Cerebral Ischemia/Reperfusion by Inhibiting Neuronal Apoptosis

Background In this study, we investigated the potential neuroprotective effect of oleuropein (OLE) on apoptotic changes via modulating Akt/glycogen synthase kinase 3 beta (Akt/GSK-3β) signaling in a rat model of cerebral ischemia/reperfusion injury (IRI). Material/Methods Sprague-Dawley male rats (12 weeks, n=200) were randomly assigned to 5 groups: sham group, vehicle (IRI+ vehicle) group, OLE (IRI+OLE) group, OLE+LY294002 (IRI+OLE+LY294002) group, and LY294002(IRI+LY294002) group. The rats were subjected to cerebral ischemia/reperfusion injury (IRI) model and treated once daily for 5 days with vehicle and OLE (100 mg/kg via intraperitoneal injection) after IRI injury. LY294002 (0.3 mg/kg) was intraperitoneally injected once at 30 min after IRI injury. Brain edema, neurological deficit, rotarod latencies, and Morris water maze (MWM) performance were evaluated after IRI. The number of dead cells were assayed by TUNEL staining. Western blot was used to detect the expression of Bcl-2, Bax, cleaved caspase-3 (CC3), neurotrophic factors, and the phosphorylation levels of Akt and GSK-3β. Results Compared with the vehicle group, brain water content, neurological deficits, rotarod latencies, and escape latency following IRI were reduced in the OLE group. Cell apoptosis and reduced neurotrophic factor caused by IRI was also attenuated by OLE. Furthermore, increased p-Akt and decreased p-GSK-3β were caused by OLE, which were associated with decrease of Bax/Bcl-2 ratio and the suppression of Caspase-3 activity after IRI. Importantly, all the beneficial effects of OLE in the vehicle group were abrogated by PI3K inhibitor LY294002. Conclusions Cerebral ischemia was protected by OLE via suppressing apoptosis through the Akt/GSK-3β pathway and upregulating neurotrophic factor after IRI.