Miracle-dz/UniFAR-FTUs huggingface dataset:
Safety and Efficacy of Endovascular Treatment of Basilar Tip Aneurysms by Coiling With and Without Stent Assistance: A Review of 235 Cases.

Background Endovascular therapy is now the preferred treatment option for basilar tip aneurysms (BTAs). Objective To compare the safety and efficacy of common endovascular techniques in the treatment of BTAs. Methods A retrospective review was conducted of 235 patients with BTAs treated with endovascular means in our institution between 2004 and 2011. Categorization was based on the presence and type of stent assistance (none, single, and Y stenting). The rates of perioperative complications, recanalization, rehemorrhage, and retreatment were analyzed. Results A total of 147 patients were treated with coil embolization and 88 patients with stent-assisted coiling (72 single stents, 16 Y stents). Thromboembolic complications occurred in 6.8% of patients in both groups. There was no associated mortality. Angiographic follow-up (mean, 23.5 months) was available in 172 patients (77.1%). Stented patients had significantly lower recanalization (17.2% vs 38.9%; P=.003) and retreatment (7.8% vs 27.8%; P=.002) rates compared with nonstented patients. Four rehemorrhages (2.7%) occurred in the coiled group, whereas none were noted in the stented group (P=.3). In paired comparisons, lower recanalization (8.3% vs 19.2%; P=.21) and retreatment (0% vs 9.6%; P=.19) rates were seen in the Y-stent group compared with the single-stent group. Thromboembolic complications occurred in 6.9% and 6.2% of patients in the single-stent and Y-stent groups, respectively (P=.91). In multivariate analysis, larger aneurysms, nonstented aneurysms, incomplete initial occlusion, and subarachnoid hemorrhage were predictors of aneurysm recanalization. Conclusion Stent-assisted coiling has significantly lower recurrence, retreatment, and rehemorrhage rates than coiling alone for the treatment of BTAs. Y stenting has the highest efficacy with low complication rates.
PLASMA LIPID AND LIPOPROTEIN LEVELS IN A DANISH POPULATION

A study of the plasma lipid and lipoprotein concentrations has been carried out in 373 persons (179 women and 194 men) including 56 obese persons (24 women and 32 men) and 26 women treated with sex hormones, mainly for contraceptive purposes. The technique for quantitative lipoprotein electrophoresis described by the authors in previous papers was used. The technique was compared with other methods and found reliable. Increasing lipid and lipoprotein level with age was demonstrated; but while this increase continued in women, the increase in men ceased at about the age of 45. The levels of triglycerides and pre‐β‐lipoproteins were found to be higher in men than in women, while phospholipids and α‐lipoproteins were higher in women. Cholesterol and β‐lipoproteins were higher in women aged 11–20 years and over 50 years than in men in the corresponding age groups. Higher levels of triglycerides and pre‐β‐lipoproteins were found in obese than in non‐obese persons regardless of sex. An observation not described before was a lower α‐lipoprotein concentration in obese than in non‐obese women. No significant influence of contraceptive sex hormone intake on the lipid and lipoprotein levels could be demonstrated.
The maturation of cutaneous reflexes studied in the upper limb in man.

Cutaneous reflex responses have been recorded from forearm flexor and extensor muscles following electrical stimulation of the fingers. Recordings have been made from premature infants, term infants and children between the age of 6 weeks and 11 years. In the new‐born, stimulation of the fingers elicits such a powerful reflex that, in general, individual stimuli will evoke a reflex synchronous action potential in both forearm flexor and extensor muscles. Individual stimuli delivered to the fingers also elicit reflex synchronous muscle action potentials in forearm flexor and extensor muscles in patients with clinical signs of upper motor neurone lesion affecting the upper limb; this has not been observed in normal adult subjects. The latency of the reflex response in the term infant is about 18 msec. Comparison of this value with the latency of the tendon jerk for these muscles would indicate a central delay for the cutaneous reflex of about 3 msec. The latencies of the cutaneous reflex and tendon jerk remain constant over the first 5 years of life. The size of the short‐latency cutaneous reflex response decreases progressively over the first year of life. In the second year of life stimulation of the fingers produces long‐ as well as short‐latency increases in recorded muscle electrical activity. The maturation of the cutaneous reflex response is discussed in terms of the maturation of function of the corticospinal tract.
Socioeconomic risk factors for asthma in Chilean young adults.

OBJECTIVES We studied the association between socioeconomic status (SES) and asthma symptoms, severity of asthma, atopy, and bronchial hyperresponsiveness (BHR) to methacholine. METHODS We studied 1232 men and women born between 1974 and 1978 in a semirural area of Chile. We assessed asthma symptoms with a standardized questionnaire, atopy with a skin-prick test to 8 allergens, and BHR to methacholine with the tidal breathing method. SES was derived from several indicators: education, occupation, completion of a welfare form, belongings, housing, number of siblings, and overcrowding. RESULTS Those with fewer belongings had more asthma symptoms. Those who had higher education and those who owned cars had fewer asthma symptoms and BHR. Overcrowding was negatively related to atopy, atopy with asthma symptoms, and BHR. Higher education and noncompletion of a welfare form were risk factors for atopy. CONCLUSION The strength and direction of the association between asthma and SES depended on what definition of asthma was analyzed. Asthma symptoms were more common among poor people. There was some support for the hygiene hypothesis, as overcrowding was associated with less wheezing with atopy, less atopy, and less BHR.
The effect of the oxidant hypochlorous acid on the L-type calcium current in isolated ventricular cardiomyocytes.

Disturbances of cellular calcium homeostasis due to oxidative stress are involved in reperfusion associated phenomena like myocardial stunning and reperfusion induced arrhythmias. This study investigates the effect of the major neutrophil-derived oxidant hypochlorous acid (HOCl) on the l-type calcium current (ICa,L) of hamster ventricular cardiomyocytes. Using the whole-cell recording configuration of the patch-clamp technique, I Ca,L was recorded over 12.5 min (0.1 Hz). Application of HOCl or buffer (for control) via a second micropipette in close proximity to the cell was started at t=1 min. To study the influence of increased intracellular calcium buffer concentration and of ATP on HOCl-induced effects, internal solutions were composed as follows (EGTA/ATP in mmol/l): group I (standard) 0.5/0.0, group II 5.0/0.0, group III 0.5/1.0, and group IV 5.0/1.0. Application of 10, 20 and 40 micromol/l HOCl (under group I-conditions) caused a dose-dependent decrease in peak ICa,L to 82+/-3.2, 66+/-4.2 and 36+/-4.3% of baseline value (v 94+/-4.8% in controls, mean+/-s.e.m., P<0.05), and integrated ICa,L without affecting apparent reversal potential, activation and inactivation kinetics. HOCl-induced (40 micromol/l) decrease in ICa,L was partially inhibited in group II and III. Peak currents of these groups averaged 51+/-4.7 and 52+/-4.2% of baseline after 11.5 min administration of HOCl. Peak current in group IV cells decreased to 65+/-3.8% of baseline value (P<0.05 between group I-IV and v controls). Oxidative stress-induced decrease in ICa,L may be explained by energy depletion or calcium overload rather than by direct oxidative inactivation of channel proteins. A decrease in ICa, L may contribute to the shortening of action potential during reperfusion.
Cortisol responses to immobilization with Telazol or ketamine in baboons (Papio cynocephalus/anubis) and rhesus macaques (Macaca mulatta)

Abstract: Little is known about the influence of Telazol on cortisol or of anesthetic agents on immunological measures, and reports of ketamine's effect on cortisol are inconsistent. We measured effects of Telazol, ketamine and blood sampling on cortisol in male rhesus macaques and male savannah baboons. We also obtained leukocyte counts in the macaques. In macaques, Telazol reduced cortisol in the morning but not in the afternoon; ketamine had no effect on cortisol in these animals. In baboons, cortisol changed little post‐Telazol but increased post‐ketamine. In macaques, lymphocyte numbers decreased following afternoon injection of Telazol, ketamine or saline. The injection and blood sampling process increased cortisol levels in monkeys not trained to extend an arm but exerted no effect on cortisol in trained macaques. Thus, the animals’ physiological responses to blood sampling and immobilization are influenced by such variables as anesthetic agent, species, time of day, and familiarity with the blood sampling process.
Analysis of patient satisfaction in Dutch and Spanish online reviews

Sentiment Analysis is a well-known task of Natural Language Processing that has been studied in different domains such as movies, phones or hotels. However, other areas like medical domain remain yet unexplored. In this paper we study different polarity classification techniques applied on health domain. We present a corpus of patient reviews composed by a Dutch part (COPOD: Corpus of Patient Opinions in Dutch) and a Spanish part (COPOS: Corpus of Patient Opinions in Spanish). Experiments have been carried out using a supervised method (SVM), a cross-domain method (OpeNER) and a dictionary lookup method for both languages. Obtained results overcome the baseline in almost all the cases and are higher than other polarity classifiers in patient domain. Regarding the bilingualism, the developed systems for Dutch and Spanish have a similar performance for F1-measure and Accuracy.
Exploratory Study of Internet Banking Technology Adoption

Internet has brought significant impact on the way people conduct life in the present-day scenario. In this premise the Indian economy has experienced rapid growth over the last decade, developing Internet Banking Technology IBT for transforming the traditional lines of banking. This shift has brought profound challenges and opportunities to both bank and its customers. Customers have found in IBT a new ease to do the financial transaction. Review of these literatures indicates that there are not many studies on IBT Adoption in Indian scenario. The review shows that existing study on IBT adoption in Indian context has shown little evidence of an integrated model for IBT Adoption. This indicates that a comprehensive research in the area of IBT adoption under Indian context is very much limited. This research attempts to analyse existing technology adoption theories for formulating an integrated framework to investigate the factors of IBT adoption in India.
Identification And Characterisation Of Chlorella Vulgaris For Biodiesel Production

The current study focuses on molecular identification and characterisation of fresh water algae (AS3) isolated from Unkal Lake, in the district of Dharwad, Karnataka, India. 18s rRNA sequencing of ITS gene, which is conserved region in most eukaryotic organisms helped to identify the genus of the organism. DNA was isolated using InstaGeneTM Matrix Genomic DNA Isolation kit. DNA amplification was done using MJ Research PTC-225 Peltier Thermal Cycler. PCR product was sequenced using the ITS1/ITS4 primers. The phylogeny was determined using blast tools in NCBI. Further characterisation of the algae was done to understand whether the organism is a suitable candidate for biodiesel production. Nile red staining was done for detection of lipid granules. Scanning electron microscopy was used to image the organism’s morphology. Biochemical parameters such as carbohydrates and protein content, total lipids were determined by standard procedures, FTIR analysis of the algal biomass was done to determine the functional groups present. Fatty acid profiling was done by Gas chromatography-Mass spectroscopy to get a note of TAG, SFA, MUFA, and PUFA which is a characteristic feature of the type of biodiesel to be produced. 18s rRNA sequencing of ITS gene confirmed that the isolated organism is chlorella vulgaris. Biochemical estimation showed the presence of 18% protein, 28% Carbohydrate, 40% lipids, 0.516 mg /g.fr. wt. Of chlorophyll and 0. 245μg /g.fr. wt of Caroteniod. FTIR of algal cells showed the presence of O-H, N-H, C=O, CH2, CH3, P=0, -O-C and C-O-C functional groups. The fatty acid profiling showed the presence of Myristic acid, Palmitoleic acid, Palmitic acid, Stearic acid, Oleic acid and Linoleic acid, these fatty acids is of high cetane number with good combustion properties for an ideal biodiesel. The obtained results will help us to determine the right candidate (organism) for economical production of biodiesel.
A Report of the Vancouver Forum on the Care of the Live Organ Donor: Lung, Liver, Pancreas, and Intestine Data and Medical Guidelines

An international conference of transplant physicians, surgeons, and allied health professionals was held in Vancouver, Canada, on September 15 and 16, 2005 to address the care of the live lung, liver, pancreas, and intestine organ donor. The Vancouver Forum was convened under the auspices of the Ethics Committee of The Transplantation Society. Forum participants included over 100 leaders in organ transplantation, representing many countries from around the world, including participants from the following continents: Africa, Asia, Australia, Europe, North and South America. The objective of the Vancouver Forum was to develop an international standard of care for the live lung, liver, pancreas and intestinal organ donor. This Vancouver Forum followed a conference convened in Amsterdam on the care of the live kidney donor (1, 2). There were four organ specific work groups at the Vancouver Forum: lung, liver, pancreas and intestine. Each organ work group addressed the following topics in concert and reported their findings in a plenary presentation to all participants:
The effect of superstructure design on stress distribution in peri-implant bone during mandibular flexure.

PURPOSE Mandibular flexure may affect stress distribution in implant-supported fixed partial dentures; however, this factor has been overlooked in most finite element analyses of the mandible. The purpose of this study was to investigate the effect of two different superstructures on stress distribution in mandibular bone during mandibular deformation caused by clenching. MATERIALS AND METHODS Three-dimensional finite element models consisting of the mandibular bone, six implants, and two- or three-piece superstructures were created. Muscle forces with definite direction and magnitude were exerted over areas of attachment to simulate two static bites of incisal and right molar clenching because, during these clenching tasks, a significant amount of mandibular deformation occurs. The stress analysis was performed using von Misses stress values. RESULTS During right molar clenching, the two-piece superstructure showed increased stress values. During incisal clenching, the three-piece superstructure inhibited mandibular deformation more than the two-piece superstructure. CONCLUSIONS Mandibular deformation was an important factor in the stress distribution of the models, and it should be considered in the design of implant-supported fixed partial dentures in the mandible.
Clinical and Pathological Correlation of Malignant Melanoma

We have attempted to review virtually all forms of cutaneous and mucocutaneous melanomas. Superficial spreading, lentigo maligna and nodular melanomas have been more thoroughly investigated and documented in previous studies. Lentigo maligna melanoma appears to have a longer duration and better prognosis than SSM or NM. The overall prognosis probably correlates better with the anatomic level and thickness of invasion than with type (Clark et al. 1975, Breslow 1970, 1975). It appears that certain pitfalls exist in either method of assessing prognosis, and it is recommended that both methods be applied in evaluating a malignant melanocytic lesion when feasible. With regard to in situ melanoma or Level I melanoma, it is our experience that such lesions can achieve a 100% cure rate when completely excised. Hence, we prefer to call such lesions severely atypical melanocytic hyperplasia, and thus avoid labeling these patients with a malignant diagnosis. The most difficult histologic challenge in diagnosing a lesion of malignant melanoma is the Spitz nevus. The pathologist should never be biased by the age of the patient, for a serious mistake can arise. We have seen a case of nodular melanoma in a 13‐year‐old girl diagnosed as Spitz nevus only to be followed by a lymph node metastasis years later. Other examples of histologic differential diagnoses of malignant melanomas include, for example, halo nevus, soft tissue sarcoma, squamous cell carcinoma with spindle cell proliferation, Paget's disease of metastatic carcinoma, (for example, from the breast). Therefore, the approach to the diagnosis of malignant melanoma necessitates an evaluation of both clinical and pathological features. Histologic study must encompass both the pattern of growth and cellular cytologic detail for successful interpretation.
Determinants of mating and sperm‐transfer success in a simultaneous hermaphrodite

The number of mating partners an individual has within a population is a crucial parameter in sex allocation theory for simultaneous hermaphrodites because it is predicted to be one of the main parameters influencing sex allocation. However, little is known about the factors that determine the number of mates in simultaneous hermaphrodites. Furthermore, in order to understand the benefits obtained by resource allocation into the male function it is important to identify the factors that predict sperm‐transfer success, i.e. the number of sperm a donor manages to store in a mate. In this study we experimentally tested how social group size (i.e. the number of all potential mates within a population) and density affect the number of mates and sperm‐transfer success in the outcrossing hermaphroditic flatworm Macrostomum lignano. In addition, we assessed whether these parameters covary with morphological traits, such as body size, testis size and genital morphology. For this we used a method, which allows tracking sperm of a labelled donor in an unlabelled mate. We found considerable variation in the number of mates and sperm‐transfer success between individuals. The number of mates increased with social group size, and was higher in worms with larger testes, but there was no effect of density. Similarly, sperm‐transfer success was affected by social group size and testis size, but in addition this parameter was influenced by genital morphology. Our study demonstrates for the first time that the social context and the morphology of sperm donors are important predictors of the number of mates and sperm‐transfer success in a simultaneous hermaphrodite. Based on these findings, we hypothesize that sex allocation influences the mating behaviour and outcome of sperm competition.
Reference command shaping for approximate dynamic inversion based model Reference Adaptive Control

A hybrid adaptive-optimal control architecture is presented, which is suitable for implementation on systems with fast, nonlinear and uncertain dynamics subject to constraints. Approximate dynamic inversion transforms the nonlinear system into an equivalent linear form. A linear error controller allows a designer chosen reference model to be tracked by the inverted plant. Model Reference Adaptive Control uses a weighted combination of basis functions in order to reduce the impact of modeling uncertainties on the closed loop dynamics. The underlying assumption is, that if the uncertainty is cancelled, the plant behaves like the inversion model and tracks the reference model exactly. Reference models are often chosen to be conservative. By employing a Model Predictive Controller to shape the reference command, the full control authority of the plant can be exploited, while simultaneously abiding input and state constraints. Since the reference model is preselected, the optimal control problem can be solved offline, drastically reducing the onboard required computational power. The control architecture is implemented for the attitude loop of a multirotor system and validated in flight test.
Crystal structures of two intermediates in the assembly of the papillomavirus replication initiation complex

Initiation of DNA replication of the papillomavirus genome is a multi‐step process involving the sequential loading of viral E1 protein subunits onto the origin of replication. Here we have captured structural snapshots of two sequential steps in the assembly process. Initially, an E1 dimer binds to adjacent major grooves on one face of the double helix; a second dimer then binds to another face of the helix. Each E1 monomer has two DNA‐binding modules: a DNA‐binding loop, which binds to one DNA strand and a DNA‐binding helix, which binds to the opposite strand. The nature of DNA binding suggests a mechanism for the transition between double‐ and single‐stranded DNA binding that is implicit in the progression to a functional helicase.
Homology‐guided mutational analysis reveals the functional requirements for antinociceptive specificity of collapsin response mediator protein 2‐derived peptides

N‐type voltage‐gated calcium (Cav2.2) channels are critical determinants of increased neuronal excitability and neurotransmission accompanying persistent neuropathic pain. Although Cav2.2 channel antagonists are recommended as first‐line treatment for neuropathic pain, calcium‐current blocking gabapentinoids inadequately alleviate chronic pain symptoms and often exhibit numerous side effects. Collapsin response mediator protein 2 (CRMP2) targets Cav2.2 channels to the sensory neuron membrane and allosterically modulates their function. A 15‐amino‐acid peptide (CBD3), derived from CRMP2, disrupts the functional protein–protein interaction between CRMP2 and Cav2.2 channels to inhibit calcium influx, transmitter release and acute, inflammatory and neuropathic pain. Here, we have mapped the minimal domain of CBD3 necessary for its antinociceptive potential.
Cytomorphology of palpable breast lesions: Diagnostic utility of FNAC in a developing country

Breast lesions including breast cancer represent a major public health issue in Sudan. Fine‐needle aspiration cytology (FNAC) is an established, simple, highly accurate, minimally invasive, and cost‐effective method of diagnosing most breast lesions. The aim of this study is to document the most common breast conditions diagnosed by means of FNAC over a two‐year period in Atbara, a city in north Sudan.