Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of Anxiety, Depression and Anger in Eating Disorders-Structural Model

Aim of current study was to offer structural model regarding role of anxiety, depression and anger in eating disorder. Noting morbidity and mushrooming trend of eating disorder in clinical settings and its antagonistic features among afflicted individuals, with respect to clinical implication and, theoretical dimensions, conducting current study seemed vital. Materials and Methods: This study was descriptive-correlational study. Statistical society of current study, consisted of 750 individuals with BMI ≥ 25, who were admitted to nutrition clinic at Sari General Hospital (Sari, Iran). Sample size was specified as 226 according to Krejcie and Morgan Table. We used DASS-20 with respect to depression, anxiety and stress assessment; Spielberger’s State-Trait Anger Expression Inventory in clinical patients with respect to anger assessment, EDDS (Eating disorder diagnostic scale) regarding assessment of eating disorders (anorexia nervosa, bulimia nervosa and binge eating disorder). With respect to data analyze, SPSS-22 and structural equation modeling and regression model via Lisrel test were used. Results: According to results of current study, anxiety, depression and aggression maintain positive and influential roles with respect to anorexia nervosa, bulimia nervosa and binge eating disorder.
Mindfulness skills in borderline personality disorder patients during dialectical behavior therapy: Preliminary results

Objective. One of the components of dialectical behavior therapy (DBT) is the use of mindfulness skills as a core component of treatment for subjects with borderline personality disorder (BPD). In this study, we investigated changes in and correlates of mindfulness skills over a 1-year follow-up including a 4-week session of intensive DBT followed by 10 months of standard DBT. Methods. Fifty-two BPD subjects were assessed several times using the Kentucky Inventory of Mindfulness Skills (KIMS) which describes mindfulness in four discrete dimensions: observing (Obs), describing (Des), acting with awareness (AwA) and accepting without judgment (AwJ). Results. AwJ was the only dimension that increased significantly over time after adjustment for potential confounding factors (β = 0.24; P = 0.0002). Increases in AwJ correlated with improvement in BPD symptoms. Conclusions. This study highlights the usefulness of investigating changes in mindfulness dimensions during DBT. AwJ is a possible mechanism for positive change. Encouraging this skill should lead to a more adaptive response to problematic situations and counteract impulsive and problematic behaviors. The lack of specific control groups means that these findings are preliminary and replication is required.
Anti-Angiogenic Drugs, Vascular Toxicity and Thromboembolism in Solid Cancer.

BACKGROUND Neo-angiogenesis, a key step in cancer progression, is a highly regulated process, in which Vascular Endothelial Growth Factor (VEGF) plays a fundamental role, thus representing the most suitable anti-angiogenic target. In the last year, a number of anti-VEGF drugs have been developed and approved for therapeutic use, especially in combination with standard chemotherapy. VEGF, however, is not only crucial for physiological and pathological angiogenesis, but also for the maintenance of vascular homeostasis, at a point that its pharmacological blockade may lead to endothelial dysfunction and adverse vascular effects, such as venous thromboembolism. The picture is further complicated by the understanding that the amount of VEGF production is influenced by genetic factors, with environmental ones accounting only for 20-30% of its variations. This has recently prompted the design of various pharmacogenetic studies to investigate the role of VEGF polymorphisms in determining the pharmacological response and safety profile of various anti-angiogenic drugs, suggesting that the analysis of VEGF genetic variants in cancer patients may further help personalize anti-angiogenic pharmacological strategies. CONCLUSION In this review, we initially focused on the biological mechanisms involved in vascular maintenance and angiogenesis. Then, discussed the efficacy and toxicity profile of some of the antiangiogenic drugs most commonly used in the treatment of solid cancer, with a particular focus on the thromboembolic complications of anti-angiogenic treatments in cancer patients. Finally, the impact of VEGF gene polymorphisms on clinical outcome and toxicity was briefly reviewed.
Nonsteroidal Anti-Inflammatory Drugs: Exploiting Bivalent COXIB/ TP Antagonists for the Control of Cardiovascular Risk.

BACKGROUND Nonsteroidal anti-inflammatory drugs (NSAIDs) are some of the most widely prescribed or dispensed over the counter analgesics and antipyretics that act by inhibiting prostaglandins and thromboxane synthesis. After the identification of a second isoform of COX, the pharmaceutical research focused on developing COX-2- selective drugs (COXIBs) considered as second generation NSAIDs that would retain the anti-inflammatory and analgesic activities of traditional NSAID without blunting the gastrointestinal cytoprotection sustained by COX1-derived products such as PGE2. However, while several clinical trials confirmed a gastrointestinal safer profile of COXIBs vs unselective COX inhibitors, increasing evidence for potential cardiovascular risk associated with COXIBs rapidly emerged. Today, there are no really safe NSAIDs to be used in chronic pain and anti-inflammatory treatments, as an adequate therapy associated with a minimal gastrointestinal damage and cardiovascular toxicity is yet to be developed. OBJECTIVE Here, we present evidences that combining the anti-aggregating and antiatherotrombotic activities of a thromboxane receptor antagonist with the antiinflammatory activity of a COXIB we could obtain a new multitarget drug providing protection against the harmful activities mediated by the COXIB component, yet exploiting its recognized therapeutic advantages as a gastrointestinal-safer anti-inflammatory drug. We also summarize recent progress achieved in this field of research and possible new strategies to obtain a new bivalent compound. CONCLUSION This possible third-generation NSAID with a safer pharmacological profile, will have all the pharmacological characteristics for the long-term therapy of chronic disorders such as inflammatory diseases or selected forms of cancer.
Acute compartment syndrome in the thigh complicating fracture of the femur. A report of three cases.

3 cas chez des patients ayant une fracture due a un traumatisme a haute energie. Dans 2 cas un saignement arteriel dans la cuisse etait la cause primitive. Dans l'autre cas une compression extrinseque et la contusion des tissus mous etaient sans doute responsables
Inter‐organisational supplier development: the case of customer attractiveness and strategic fit

Purpose – This paper aims to investigate the concept of inter‐organisational supplier development programs and to stress the importance of considering suppliers' interest and motivation when implementing development initiatives.Design/methodology/approach – This paper's theoretical framework is based on an in‐depth literature review that analyses how extant supplier development literature considers an inter‐organisational approach. A single case study of eight inter‐organisational relationships is also included.Findings – The literature review reveals a lack of focus on inter‐organisational approaches to supplier development, even though the literature mentions it as a missing theme. Customer attractiveness is presented as one approach that takes supplier view and motivation into consideration. This idea is supported by the case study, which indicates that supplier performance is influenced by perceived customer attractiveness.Research limitations/implications – This paper is based on only a single case s.
Information‐centric networking and multimedia services: present and future challenges

The emerging information‐centric networking (ICN) paradigm is gaining worldwide the attention of academia and industrial research communities, thanks to its inherent ability to support also the next generation information and communication technology services beyond the current host‐centric Internet rationale. In this context, significant scientific efforts are being devoted to the investigation of ICN‐based multimedia systems because they represent the most popular use case for Internet users. In order to offer a unifying view on such valuable contributions, this paper presents a thorough review of the state of the art, a comprehensive framework to classify the most significant proposals, an overlook at the road ahead towards mature ICN‐based multimedia systems and a critical discussion on available tools. Our final wish is twofold: from one hand, this paper will provide a useful starting point for beginners in the field; whereas, from the other hand, it will help researchers already working on ICN‐related topics in finding a common agreement on participated scientific activities. Copyright © 2013 John Wiley & Sons, Ltd.
Dendritic Cells Transduced With HIV Nef Express Normal Levels of HLA‐A and HLA‐B Class I Molecules

Summary: HIV Nef protein is important for viral pathogenesis and disease progression. Nef downregulates CD4 and major histocompatibility antigens on the surface of HIV‐infected T cells. HIV also infects dendritic cells. We wanted to determine if Nef had a similar function in professional antigen‐presenting cells, where downregulation of Class I could have important effects on the initiation of HIV specific cytolytic T cell responses. We infected human dendritic cells with adenovirus expressing Nef. In contrast to T cells and Hela cells, HLA‐A and HLA‐B molecules are not downregulated nor are other class I molecules increased. We show that, in dendritic cells, HIV Nef has little effect on CD4 or Class I expression.
Cortisol production rate. 8. Pregnancy.

ABSTRACT Cortisol production rates (CPRs) and urinary 17-hydroxycorticosteroid (17-OHCS) excretion were studied in 13 subjects in mid- and late pregnancy and compared with those of nonpregnant women. CPRs and 17-OHCS were significantly lower (p<0.05) in pregnant subjects. The values were still significantly lower when body surface area and body weight corrections were applied. Five women during the labor of pregnancy had elevated CPRs and 17-OHCS. The decreased CPR and 17-OHCS excretion during pregnancy is probably secondary to the increased cortisol-protein binding which itself is due to increased estrogen production. During labor the increased adrenocortical function is probably a “stress” phenomenon.
Propagation of Turing patterns in a plankton model

The paper is devoted to a reaction–diffusion system of equations describing phytoplankton and zooplankton distributions. Linear stability analysis of the model is carried out. Turing and Hopf stability boundaries are found. Emergence of two-dimensional spatial structures is illustrated by numerical simulations. Travelling waves between various stationary solutions are investigated. Transitions between homogeneous in space stationary solutions and Turing structures are studied.
Small ubiquitin‐related modifier‐1 modification regulates all‐trans‐retinoic acid‐induced differentiation via stabilization of retinoic acid receptor α

Small ubiquitin‐related modifier‐1 (SUMO‐1) modification has been implicated in many important cellular processes, including cell cycle progression, apoptosis, cellular proliferation, and development, but its role in all‐trans‐retinoic acid (ATRA)‐induced differentiation processes of cancer cells remains unclear. Here, we report for the first time that ATRA‐induced differentiation of leukemia and osteosarcoma is accompanied by a decrease in the level of SUMO‐1 protein. Our results also demonstrated that depletion or inhibition of SUMO‐1 blocks ATRA‐induced differentiation, suggesting that SUMO‐1 is critical for the differentiation effect of ATRA. Further studies indicated that SUMO‐1‐promoted ATRA‐induced differentiation might be associated with the stabilization of retinoic acid receptor α (RARα), protecting it from degradation. Moreover, our results suggested that Lys399 is a major site for SUMO‐1 conjugation of RARα. We also found that RARα enhanced the transcription of its target genes, which might also contribute to the enhanced differentiating effects of ATRA; however, mutation of Lys399 of RARα inhibits the extents of both SUMO‐1 modification and ATRA‐induced differentiation. Together, these results indicate that SUMO‐1 modification of RARα is a potent mechanism for balancing proliferation and differentiation by controlling the stability of RARα in cancer cells. SUMO‐1 modification may thus serve an important role in controlling ATRA‐induced cell differentiation in cancers.
DOSE RESPONSE RELATIONSHIPS OF DIFFERENT REAGENTS FOR PLATELET AGGREGATION

The synergism between ADP– Epinephrine and Epinephrine – Collagen has been determined in this study by means of turbidometric method, which measures changes in optical density of platelet suspension. The study was carried out at the department of Hematology, Armed Forces Institute of Pathology, Rawalpindi. The subthreshold concentrations of each of the agonists were established with the help of dose response curve. By adding these agonists in subthreshold concentrations, the synergism between ADP – Epinephrine and Epinephrine– Collagen was determined.
Production of adiponectin, an anti-inflammatory protein, in mesenteric adipose tissue in Crohn’s disease

Background and aims: A characteristic feature of Crohn’s disease (CD) is mesenteric adipose tissue hypertrophy. Mesenteric adipocytes or specific proteins secreted by them may play a role in the pathogenesis of CD. We recently identified adiponectin as an adipocyte specific protein with anti-inflammatory properties. Here we report on expression of adiponectin in mesenteric adipose tissue of CD patients. Methods and results: Mesenteric adipose tissue specimens were obtained from patients with CD (n = 22), ulcerative colitis (UC) (n = 8) and, for controls, colon carcinoma patients (n = 28) who underwent intestinal resection. Adiponectin concentrations were determined by enzyme linked immunosorbent assay, and adiponectin mRNA levels were determined by real time quantitative reverse transcription-polymerase chain reaction. Tissue concentrations and release of adiponectin were significantly increased in hypertrophied mesenteric adipose tissue of CD patients compared with normal mesenteric adipose tissue of CD patients (p = 0.002, p = 0.040, respectively), UC patients (p = 0.002, p = 0.003), and controls (p<0.0001, p<0.0001). Adiponectin mRNA levels were significantly higher in hypertrophied mesenteric adipose tissue of CD patients than in paired normal mesenteric adipose tissue from the same subjects (p = 0.024). Adiponectin concentrations in hypertrophied mesenteric adipose tissue of CD patients with an internal fistula were significantly lower than those of CD patients without an internal fistula (p = 0.003). Conclusions: Our results suggest that adipocytes in hypertrophied mesenteric adipose tissue produce and secrete significant amounts of adiponectin, which could be involved in the regulation of intestinal inflammation associated with CD.
Total ionizing dose effects on deca-nanometer fully depleted SOI devices

Total ionizing dose effects are investigated for the first time in deca-nanometer fully depleted (FD) silicon-on-insulator (SOI) devices. Charge trapping and the influence of device architecture are investigated in transistors with and without external body contacts. A radiation-induced high current regime is measured in floating body devices, both at high and low drain voltages. The mechanism responsible for the onset of this high current regime is investigated by 2D numerical simulations, and shown to result from the combined effect of short gate length and floating body potential in the intrinsic Si film. Transistors with a doped Si film are less sensitive to the high current regime. The use of external body contact in the device architecture completely stops the onset of high current regime, whatever the device gate length.
Locally strained ultra-thin channel 25nm narrow FDSOI devices with metal gate and mesa isolation

Strained silicon devices offer very high carrier mobility. If we put them on an SOI substrate we also improve short-channel control and junction leakage. In this paper, we present a new approach to introducing strain in very thin silicon layers. NMOS and PMOS CV/I performance of 0.2 ps and 0.3 ps, respectively, is the highest reported. We analyze 3D geometrical effects on stress, mobility, and drive currents using the 3D process and device simulator, Taurus.
Analysis of Hospital Staff Exposure Risks and Awareness about Poor Medical Waste Management - A Case study of the Tabuk Regional Healthcare System - Saudi Arabia

Aims: The objective of the current study is to seek ways to improve the present situation on occupational risks and awareness about poor medical waste management. It introduces analysis which measures the awareness of hospital staff and knowledge of medical waste processing awareness of existing management methods, health and environmental impacts, realizing policies and concerns of the public about the existing medical waste management processes. Methods: This study utilizes both face- to- face interview and selfadministered questionnaires regarding staff age, years in service, infectious exposure accidents, and knowledge of the concept of medical waste and associated health and environmental impacts of poor medical waste management. Sixty two Healthcare Facilities (HCFs), including 15 large size HCFs (hospitals), and 47 medium to small size HCFs (medical laboratories and healthcare medical centers), are investigated. Herein, statistical multivariate procedures namely factor analysis and multiple regressions procedures are conducted using SPSS v.18. 0 computer software. Results: Results indicate that the strongest exposure risk factor to sharp and needle stick injuries exists for Health care personnel (HCP) who are over 45 years old. Another significantly related factor is spending 3 years or less in service. Also, results on awareness and basic knowledge indicate that about 21% of hospital staff interviewed had a fair knowledge of the concept of medical waste, and about 58% are aware of the associated health and environmental impacts. A further 26.7% and 15.1% are either unaware or uncertain of the associated health risks and exposure risks of poor medical waste management. However, 42.7% of the respondents are unaware of any policy of any type related to the issue of medical waste while 62.1% had never attended any training course or workshops during their service. The results further reveal that 32% of the personnel interviewed had never received any biomedical waste management training from their healthcare managers concerning infectious accidents resulted from sharp and needle stick injuries (SHNSI). Conclusion: There is a great need to develop and adopt a comprehensive healthcare management strategy which includes three keys to success, namely: multi- sectorial cooperation, policy and legal framework, rigorous program for personnel training and raising awareness. Training programs for bodies of HCFs would help in simplifying all delivered guidelines on medical waste management. Such measures would lead to better treatment and controlling the process of monitoring made by administration officers. Recently, Saudi Arabia has implemented many exhaustive training and awareness- raising programs on the safe and proper management of medical wastes.
Measuring the constructs and mechanism of the value co-creation system with customers

Involving customers to co-create value is an important strategy for businesses competing to satisfy personalized customer demands and to gain competitive advantages. However, the research of co-creation value with customer is still in an early stage. In a search for this new competitive strategy, the literature on value co-creation largely overlooked constructs development and the interaction mechanism among the constructs. Using empirical data collected in the middle of China, this study provides an empirical examination into the mechanism of the three constructs in a co-creation system and makes the contribution in the following three aspects. First, this study developed and assessed three constructs in a value co-creation system based on the empirical data. The measures satisfy key measurement criteria including unidimensionality, convergent validity, discriminant validity, and reliability. Second, the results of this study evidence that the emphasis of co-creation with customers may not only positively impact on customerization capabilities, but also directly impact on service capability. These capabilities are significantly different from those generated from traditionally isolated value creation system. Third, the study finds the relationship between the customerization capabilities and service capabilities. Customerization capability significantly impacts on firm's service capabilities.
Identification of Tuberin, the Tuberous Sclerosis-2 Product. TUBERIN POSSESSES SPECIFIC Rap1GAP ACTIVITY (*)

Tuberous sclerosis (TSC) is a human genetic syndrome characterized by the development of benign tumors in a variety of tissues, as well as rare malignancies. Two different genetic loci have been implicated in TSC; one of these loci, the tuberous sclerosis-2 gene (TSC2), encodes an open reading frame with a putative protein product of 1784 amino acids. The putative TSC2 product (tuberin) contains a region of limited homology to the catalytic domain of Rap1GAP. We have generated antisera against the N-terminal and C-terminal portions of tuberin, and these antisera specifically recognize a 180-kDa protein in immunoprecipitation and immunoblotting analyses. A wide variety of human cell lines express the 180-kDa tuberin protein, and subcellular fractionation revealed that most tuberin is found in a membrane/particulate (100,000 g) fraction. Immunoprecipitates of native tuberin contain an activity that specifically stimulates the intrinsic GTPase activity of Rap1a. These results were confirmed in assays with a C-terminal fragment of tuberin, expressed in bacteria or Sf9 cells. Tuberin did not stimulate the GTPase activity of Rap2, Ha-Ras, Rac, or Rho. These results suggest that the loss of tuberin leads to constitutive activation of Rap1 in tumors of patients with tuberous sclerosis.
The preparation of highly active antimicrobial silver nanoparticles by an organometallic approach

Silver nanoparticles of small size with a high surface to volume ratio have been prepared using an organometallic approach. For this, the complex NBu4[Ag(C6F5)2] has been treated with AgClO4 in a 1:1 molar ratio, giving rise to the nanoparticle precursor [Ag(C6F5)] in solution. Addition of one equivalent of hexadecylamine (HDA) and 5 h of reflux in toluene leads to a deep yellow solution containing monodisperse silver nanoparticles (Ag NPs) of ca. 10 nm. This approach leads to nanoparticles with almost uncontaminated surfaces which make them very reactive. Antimicrobial studies show that these nanoparticles are very active as antimicrobial agents. Very low concentrations between 12 and 25 µg ml−1 of Ag NPs are enough to produce bacteriostatic and bactericidal effectiveness.