Miracle-dz/UniFAR-FTUs huggingface dataset:
Divinyl Chlorophyll(ide) a Can Be Converted to Monovinyl Chlorophyll(ide) a by a Divinyl Reductase in Rice1[W]

3,8-Divinyl (proto)chlorophyll(ide) a 8-vinyl reductase (DVR) catalyzes the reduction of 8-vinyl group on the tetrapyrrole to an ethyl group, which is indispensable for monovinyl chlorophyll (Chl) synthesis. So far, three 8-vinyl reductase genes (DVR, bciA, and slr1923) have been characterized from Arabidopsis (Arabidopsis thaliana), Chlorobium tepidum, and Synechocystis sp. PCC6803. However, no 8-vinyl reductase gene has yet been identified in monocotyledonous plants. In this study, we isolated a spontaneous mutant, 824ys, in rice (Oryza sativa). The mutant exhibited a yellow-green leaf phenotype, reduced Chl level, arrested chloroplast development, and retarded growth rate. The phenotype of the 824ys mutant was caused by a recessive mutation in a nuclear gene on the short arm of rice chromosome 3. Map-based cloning of this mutant resulted in the identification of a gene (Os03g22780) showing sequence similarity with the Arabidopsis DVR gene (AT5G18660). In the 824ys mutant, nine nucleotides were deleted at residues 952 to 960 in the open reading frame, resulting in a deletion of three amino acid residues in the encoded product. High-performance liquid chromatography analysis of Chls indicated the mutant accumulates only divinyl Chl a and b. A recombinant protein encoded by Os03g22780 was expressed in Escherichia coli and found to catalyze the conversion of divinyl chlorophyll(ide) a to monovinyl chlorophyll(ide) a. Therefore, it has been confirmed that Os03g22780, renamed as OsDVR, encodes a functional DVR in rice. Based upon these results, we succeeded to identify an 8-vinyl reductase gene in monocotyledonous plants and, more importantly, confirmed the DVR activity to convert divinyl Chl a to monovinyl Chl a.
Sodium hyaluronate eye drops in the treatment of dry eye disease: an open label, uncontrolled, multi-centre trial.

BACKGROUND Dry eye disease (DED) is one of the most frequently encountered ocular morbidities. The objective of this study was to assess the performance of sodium hyaluronate eye drop for eight weeks in patients with DED. PATIENTS AND METHODS This was a multi-centre, open-label, uncontrolled clinical trial carried out at different centres of Pakistan, from August 2009 to November 2010. A total of 250 diagnosed patients of Dry Eye who met the inclusion criteria were included in the study. After informed written consent, all patients having at least 2 of the Dry Eye symptoms, and at least 1 of the tests (Tear Film Break-up time (TBUT) < or = 10 second, Schirmer's test < or = 6 mm/5 min, and positive corneal staining) were enrolled. Tolerability/safety assessments consisted of monitoring and recording of adverse events and physical examinations at baseline, 4th week and 8th week. RESULTS Out of 250 allocated patients 13 dropped out. The mean age of the patients was 47.6 +/- 13.8 year and out of 237 patients 86 (36.3%) were men and 151 (63.7%) were women. At the initial visit the foreign body sensation was 80%, itching 68%, burning 58%, watering 38%, photophobia 38%, and feeling of dryness was 16%. At the 3rd visit the foreign body sensation decreased to 32%, itching to 32%, burning to 20%, watering to 12%, photophobia to 18%, and feeling of dryness to 14%. CONCLUSION Sodium hyaluronate has a beneficial effect on the conjunctival epithelium in a well-defined and homogeneous population of patients with dry eye and can be considered useful for the treatment of dry eye.
The Impact of Formal and Informal Distance on Gender Equality Approaches: The Case of a British MNC in Saudi Arabia

This study explores the forces that promote and hinder gender equality efforts of a multinational corporation (MNC) operating in the Middle East. Specifically, we draw from a case study to document the formal and informal pressures exerted on a British MNC operating in Saudi Arabia to better understand the multiple forces that influence gender equality approaches in the host country. Our findings suggest that while formal institutions such as the legal requirements and localization policies support gender equality, informal forces that are rooted in the cultural norms and traditions are formidable in hindering such efforts and in reinforcing the status quo. The insights generated from our study have the potential to inform public policy makers and organizational decision makers to locate the right policy tool to promote gender equality. © 2016 Wiley Periodicals, Inc.
Four-year prospective study of lung function in workers in a high altitude (4000 m) mine.

The aim of this study was to determine if work at high altitude is associated with accelerated lung function decline and if smoking could further accelerate this decline. Subjects working at high altitude (3800 to 4500 m) in a gold mine on shift-rotation basis were included, and 7320 spirometry reports were obtained throughout a 4-yr observation period (2005-2009). Out of 3368 selected reports with acceptable quality, for 842 patients aged 38.9 ± 8.6 yr we analyzed annual decline in vital capacity (VC), forced vital capacity (FVC), and forced expiratory volume during the first second (FEV(1)). VC was reduced by 46.5 mL, FVC by 67.8 mL, and FEV(1) by 74.5 mL a year, greater than in historical controls. In those having initial FEV(1)/FVC below 70%, yearly VC decline was 59.4 mL, FEV(1) -58.6 mL. In long-term workers with no initial obstruction, FEV(1) declined slower (67.2 vs. 101.3 mL/yr (p < 0.001); but VC and FVC decline did not differ. Work at high altitude for years may be a factor that accelerates lung function decline, and the rate of decline along with confounding factors should be the subject of future studies.
Comparing MR imaging and CT in the staging of gastric carcinoma.

OBJECTIVE The purpose of this study was to assess the usefulness of breath-hold two-dimensional (2D) fast low-angle shot (FLASH) and T2-weighted turbo spin-echo fast MR imaging compared with helical CT in the staging of gastric carcinoma. SUBJECTS AND METHODS Thirty patients with gastric carcinoma underwent preoperative MR imaging and helical CT. MR imaging at 1.5 T was performed immediately after the intramuscular injection of scopolamine and the oral administration of water or effervescent granules. Breath-hold 2D FLASH T1-weighted images in all three planes, turbo spin-echo T2-weighted axial images, and gadolinium-enhanced fat-suppressed 2D FLASH axial images were included. Helical CT was performed 60 sec after initiation of i.v. contrast medium injection (2.5-3 ml/sec). Two groups of two radiologists each independently analyzed the MR and helical CT findings, and these results were compared with the pathologic findings. RESULTS For T staging, MR imaging accuracy was higher than that of helical CT (73.3% and 66.7%, respectively); however, the accuracies of the two methods were not significantly different from each other (McNemar test, p > 0.05). Overstaging was noted in 6.7% of cases with MR imaging and 10% with helical CT. Understaging was noted in 20% of cases with MR imaging and 23.3% with helical CT. For N staging, the accuracies of MR imaging and helical CT were 55% and 58.6%, respectively, with no statistical significance (overstaging, 10% and 6.9%; understaging, 34.5% and 34.5%, respectively). CONCLUSION MR imaging was comparable to helical CT in the T and N staging of gastric cancer.
Characteristics of medical practices in three developed managed care markets.

OBJECTIVE To describe physician practices, ranging from solo and two-physician practices to large medical groups, in three geographically diverse parts of the country with strong managed care presences. DATA SOURCES/STUDY DESIGN Surveys of medical practices in three managed care markets conducted in 2000-2001. STUDY DESIGN We administered questionnaires to all medical practices affiliated with two large health plans in Boston, MA, and Portland, OR, and to all practices providing primary care for cardiovascular disease patients admitted to five large hospitals in Minneapolis, MN. We offer data on how physician practices are structured under managed care in these geographically diverse regions of the country with a focus on the structural characteristics, financial arrangements, and care management strategies adopted by practices. DATA COLLECTION A two-staged survey consisting of an initial telephone survey that was undertaken using CATI (computerized assisted telephone interviewing) techniques followed by written modules triggered by specific responses to the telephone survey. PRINCIPAL FINDINGS We interviewed 468 practices encompassing 668 distinct sites of care (overall response rate 72 percent). Practices had an average of 13.9 member physicians (range: 1-125). Most (80.1 percent) medium- (four to nine physicians) and large-size (10 or more physicians) groups regularly scheduled meetings to discuss resource utilization and referrals. Almost 90 percent of the practices reported that these meetings occurred at least once per month. The predominant method for paying practices was via fee-for-service payments. Most other payments were in the form of capitation. Overall, 75 percent of physician practices compensated physicians based on productivity, but there was substantial variation related to practice size. Nonetheless, of the practices that did not use straight productivity methods (45 percent of medium-sized practices and 54 percent of large practices), most used arrangements consisting of combinations of salary and productivity formulas. CONCLUSIONS We found diversity in the characteristics and capabilities of medical practices in these three markets with high managed care involvement. Financial practices of most practices are geared towards rewarding productivity, and care management practices and capabilities such as electronic medical records remain underdeveloped.
The role of the monkey fetus in the exchange of the water and sodium of the amniotic fluid.

Isotopic tracers allow for the expedient investigation of the exchange of elements or metabolic products between the maternal organism and conceptus. The quantity of carrier transferred per unit of time can be estimated from the behavior of tracers if the experimental data are subjected to the proper mathematical treatment. The general background and practical applications of the theory of multi-compartment systems to related biologic problems have recently been reviewed (1). Depending upon the aim of the investigation and the nature of the available experimental data, one can subdivide a given system into an arbitrary number of hypothetical compartments which exchange, or are assumed to exchange, their constituents at constant rates. If such a system is to be completely defined, time-activity curves for all compartments must be known and all must be accessible. Once the applicability of a certain kinetic model is established, the transfer rates can be calculated from a minimum of experimental data. It is the purpose of these investigations to test the applicability of a proposed kinetic model in order to provide the theoretical basis for further studies on clinical material. It is known that the human fetus participates in the exchange of water and electrolytes between amniotic fluid and mother (2), but because of its inaccessibility a quantitative formulation of these mechanisms is not easily accomplished. A knowledge of the tracer concentration in fetal blood as a function of time is a prerequisite for the calculation of transfer rates. Such a time-activity curve for the fetal compartment can be determined directly on some experimental animals where
The role of governance systems and rules in wind energy development: evidence from Minnesota and Texas

Wind energy presents significant opportunity to provide a series of public goods. Drawing on the ideas of J.Q. Wilson and E. Ostrom, we compare options to overcome the obstacles that stand in the way of deploying wind energy in two US states, Texas and Minnesota. Texas outperformed Minnesota in deploying wind energy technology despite Minnesota’s ample wind and other natural advantages. To explain this gap in performance, we argue that Texas outperformed Minnesota because of a more fitting governance system and rules for determining (i) boundaries, (ii) cost and benefit allocation, (iii) conflict resolution, and (iv) rule revision. Our approach sheds an alternative yet overlooked lens upon the topic of wind energy development by focusing on how the concentration of power and authority in the hands of a few dominant public and private elites can lead to the successful deployment of a complex renewable technology under some circumstances.
Immune responses to Aspergillus antigen in IL‐4‐/‐ mice and the effect of eosinophil ablation

Background: Exposure to Aspergillus fumigatus allergens results in enhanced total serum IgE and peripheral blood eosinophils in mice. The associated pulmonary inflammation and immunologic responses are comparable to those detected in human allergic bronchopulmonary aspergillosis. Allergen‐induced cytokines are thought to regulate the inflammatory and immune responses in these animals.
Ecological factors predictive of wild spider monkey (Ateles belzebuth) foraging decisions in Yasuní, Ecuador

Because fruiting trees are uncommon in tropical forests, frugivorous primates experience selective pressure to incorporate knowledge of where to find feeding trees, what to expect when they arrive there, and when they can return after depleting a tree. I investigated these abilities in wild spider monkeys (Ateles belzebuth) in Yasuní, Ecuador, by analyzing the characteristics of feeding trees that drive foraging decisions. Foraging data were derived from four 2‐week follows of focal adult females, conducted between May and December 1999, during which I measured and mapped all trees in which the focal subject fed, feeding bout duration, and the number of conspecifics feeding simultaneously with the focal. Taking into account the order in which feeding trees were visited across each follow, I analyzed each foraging decision from the second week of a follow, treating all previously visited trees as options for visits. I scored each option tree in terms of nine ecological variables, including the distance from the decision to each location tree, DBH, recent feeding time and mean feeding times for the focal and other monkeys present, and the interval in hours between the foraging decision and the most recent visit to each option tree. I then examined the predictive strength of the model using logistic regression analysis, comparing characteristics of selected trees to those not selected. The overall model successfully predicted trees selected by focal monkeys (r2 = 0.27). Monkeys preferentially moved to nearby, large canopy trees, in which previous feeding success was high, and which were visited after an interval of 3.5 days. Interval mattered most for medium and large trees, but did not predict selection for trees <10 cm DBH. Despite the large home range and large numbers of trees, Yasuní spider monkeys appeared to integrate spatial, value, and temporal information when deciding where to feed. Am. J. Primatol. 76:1185–1195, 2014. © 2014 Wiley Periodicals, Inc.
The evolutionary history of the hominin hand since the last common ancestor of Pan and Homo

Molecular evidence indicates that the last common ancestor of the genus Pan and the hominin clade existed between 8 and 4 million years ago (Ma). The current fossil record indicates the Pan‐Homo last common ancestor existed at least 5 Ma and most likely between 6 and 7 Ma. Together, the molecular and fossil evidence has important consequences for interpreting the evolutionary history of the hand within the tribe Hominini (hominins). Firstly, parsimony supports the hypothesis that the hand of the last common ancestor most likely resembled that of an extant great ape overall (Pan, Gorilla, and Pongo), and that of an African ape in particular. Second, it provides a context for interpreting the derived changes to the hand that have evolved in various hominins. For example, the Australopithecus afarensis hand is likely derived in comparison with that of the Pan–Homo last common ancestor in having shorter fingers relative to thumb length and more proximo‐distally oriented joints between its capitate, second metacarpal, and trapezium. This evidence suggests that these derived features evolved prior to the intensification of stone tool‐related hominin behaviors beginning around 2.5 Ma. However, a majority of primitive features most likely present in the Pan‐Homo last common ancestor are retained in the hands of Australopithecus, Paranthropus/early Homo, and Homo floresiensis. This evidence suggests that further derived changes to the hands of other hominins such as modern humans and Neandertals did not evolve until after 2.5 Ma and possibly even later than 1.5 Ma, which is currently the earliest evidence of Acheulian technology. The derived hands of modern humans and Neandertals may indicate a morphological commitment to tool‐related manipulative behaviors beyond that observed in other hominins, including those (e.g. H. floresiensis) which may be descended from earlier tool‐making species.
Secondary Education and Content Literacy in Inclusive Classrooms

The purpose of this research study was to examine the impact on teachers’ understanding and use of content literacy strategies at the secondary level. Teachers’ perceptions, perspectives, understanding and implementation of content literacy practices were examined over six months to determine study effects. In the voluntary professional development (PD) series, participants completed preand postPD surveys, preand postPD focus group interviews, preand postPD peer and researcher observations, along with online and face-to-face PD sessions. It was expected that the participants’ content literacy teaching practices would increase by participating in this multidimensional sustained PD project.
Anhidrosis in multiple system atrophy involves pre‐ and postganglionic sudomotor dysfunction

The objective of this study was to characterize the degree, pattern, lesion site, and temporal evolution of sudomotor dysfunction in multiple system atrophy (MSA) and to evaluate differences by parkinsonian (MSA‐parkinsonism) and cerebellar (MSA‐cerebellar) subtypes.
Cost-effectiveness of induction after preterm premature rupture of the membranes.

OBJECTIVE Our purpose was to design a decision analytic model to evaluate the optimal length of time for expectant management after preterm premature rupture of the membranes between 32 and 36 weeks' gestation. STUDY DESIGN Five models were created for 32 to 36 weeks' gestation. Probabilities for outcomes were obtained from medical center databases. Cost data were collected from the Health Care Microsystem database and were based on 1996 dollars. RESULTS The optimal time of delivery to minimize major morbidity was 34 to 36 weeks' gestation, depending on the time of rupture. When only major morbidity was considered, the most cost-effective approach between 32 to 34 weeks was to deliver 1 week after rupture. At 35 to 36 weeks, the most cost-effective approach was to deliver at presentation. CONCLUSION The current method of treating all patients with ruptured membranes similarly and delivery at 34 weeks' gestation is not risk minimizing or cost-effective. By delivery 1 week after rupture at 32 to 34 weeks and immediately at 35 to 36 weeks, significant morbidity can be avoided.
A double‐blind, randomized, placebo‐controlled trial of itopride (100 and 200 mg three times daily) on gastric motor and sensory function in healthy volunteers

Abstract Itopride, a dopamine D2 antagonist and acetylcholinesterase inhibitor, significantly improved symptoms in patients with functional dyspepsia in one phase II randomized trial. However, the mechanisms by which itopride may improve symptoms are unknown. We aimed to compare the effects of two doses of itopride and placebo on gastric volumes, gastric emptying, small bowel transit and satiation in female and male healthy volunteers. Randomized, double‐blind, placebo‐controlled study evaluated gastric function before and after 7 days of itopride 100 mg (n = 16) or 200 mg (n = 15) or placebo (n = 15) t.i. d. Validated methods were used to study gastric accommodation (single photon emission computed tomography), gastric emptying and orocecal transit and satiation postnutrient challenge. The three arms were comparable with regard to age, gender and body mass index. There were no statistically significant effects of itopride on gastric emptying, orocecal transit, fasting gastric volume, maximum tolerated volume or aggregate symptom score with nutrient drink challenge. Postprandial (PP) change in gastric volume differed in the three groups (P = 0.019): 625[±28 (SEM)], 555(±26) and 512(±33) in placebo, itopride 100 and 200 mg groups, respectively. In healthy subjects, itopride reduced total PP gastric volume without accelerating gastric emptying or significantly altering gastric motor and sensory function in healthy individuals.
Analysis of Predictive Factors on Minors’ Mental Health According to the Spanish National Health Survey

Research on minors’ mental health is an increasingly developing area. Given the increased prevalence of disorders, it seems necessary to analyze the factors that can affect poor mental health. This study analyzes the influence of occupational class, educational level, age, sex and perceived mental health of Spanish children, which is measured through the Strengths and Difficulties Questionnaire. The sample consists of 3599 minors between 4 and 14 years old, who were interviewed through the Spanish National Health Survey 2011. Our results indicating the significant (p < 0.05) relationship between mental health, occupational class (OR 0.533) and minors’ health in the last year (OR 0.313) are shown. However, gender (OR 1.187) and educational level of Pre-School Education in relation to Secondary Education (OR 1.174) and Primary Education (OR 0.996) do not generate significant differences. In conclusion, we consider it necessary to design and implement public policies aimed at improving the care system for children who have had poor or regular health in the last year, and whose parents are positioned in the lowest part of the occupational scale.
Morphologic classification and stress analysis of the mandibular bone in the premolar region for implant placement.

PURPOSE The objective of this study was to assess the influence of mandibular morphology on the stress and strain distributions in the bone supporting an implant. MATERIALS AND METHODS Subjects were selected from patients with missing mandibular premolar teeth. Computed tomographic scans of the premolar region were classified into nine groups based on the overall bone morphology and the relative position of the alveolar crest. Finite element models of the bone on the basis of this classification, with inserted implants and superstructures, were constructed. A load of 200 N applied 30 degrees buccal from the vertical axis was directed toward the occlusal surface. RESULTS One hundred two partially (n = 98) and completely (n = 4) edentulous subjects were recruited. Their ages ranged from 40 to 79 years (mean age, 60.5 years; 41 men and 61 women). Approximately 56% of the patients showed bone widening in the caudal direction. The maximum compressive stresses were shown in the lingual cervical regions. An influence of overall bone morphology on stress distribution was not observed; however, the alveolar crest contour clearly affected the maximum stress and strain values. Compressive microstrain above 4,000 was observed only when the alveolar crest was lingually located relative to the body of the mandible. These high strain levels were concentrated at the lingual cervical margin, with volumes ranging from 0.04 to 0.07 mm3. CONCLUSION The contour of the alveolar crest potentially plays a critical role in maintaining the bone levels surrounding implants.