Miracle-dz/UniFAR-FTUs huggingface dataset:
Mechanisms of snowboarding-related severe head injury: shear strain induced by the opposite-edge phenomenon.

OBJECT To date, there has been no published study in which the focus was on the mechanisms of head injuries associated with snowboarding. The purpose of this study was to identify these mechanisms. METHODS The patient population consisted of 38 consecutive patients with snowboarding-related major head injuries who were treated at two hospitals in Japan, where for years many winter sports injuries have been treated. The skill level of the snowboarder, the cause of the accident, the direction of the fall, the site of impact to the head, and the condition of the ski slope were examined. The injuries were classified as coup, contrecoup, or shear injuries. The predominant features of snowboarding-related major head injuries included: falling backward (68% of cases), occipital impact (66% of cases), a gentle or moderate ski slope (76% of cases), and inertial injury (76% of cases [shear injury in 68% and contrecoup injury in 8% of the patients]). Acute subdural hematoma frequently occurred after a patient fell on the slope (p = 0.025), fell backward (p = 0.0014), or received an occipital impact (p = 0.0064). Subcortical hemorrhagic contusions frequently occurred after the patient fell during a jump (p = 0.0488), received a temporal impact (p = 0.0404), or fell on the jump platform (p = 0.0075). Shear injury frequently occurred after a fall that occurred during a jump or after simple falls on the ski slope, and contact injury was frequently seen after a collision (p = 0.0441). CONCLUSIONS The majority of severe head injuries associated with snowboarding that occur after a simple fall on the slope are believed to involve the opposite-edge phenomenon, which results from a fall backward on a gentle or moderate slope causing occipital impact. The use of a device to protect the occiput is proposed to reduce head injuries associated with snowboarding.
Falling televisions: The hidden danger for children.

BACKGROUND/PURPOSE The United States Consumer Product Safety Commission (USCPSC) recently has reported a significant number of injuries and deaths in the home related to televisions (TV) falling on children. To date, little is known regarding the significance of this mechanism of injury in childhood trauma. The current investigation was designed to examine the risk factors, spectrum of injuries, and operative intervention required in children injured by falling televisions. METHODS The records of all patients 0 to 16 years of age with television-related injuries and entered in the Pennsylvania Trauma Outcome Study (PTOS) between 1989 and 1999 were reviewed. The authors examined Glascow coma scale (GCS), injury severity score (ISS), length of hospital stay (LOS), major injuries sustained, and operative procedures performed. Fourteen of the children in the PTOS were seen at the Benedum Pediatric Trauma Center at the Children's Hospital of Pittsburgh. In these 14 children, a review of the medical records was performed for a detailed description of the accident scenario. RESULTS Forty-three children sustained television-related injuries during this period. Nearly 56% of these children were </= years; 60% were boys. The mortality rate was 11% with 80% of the deaths occurring in children </= years. Furthermore, these children sustained the highest ISS and LOS and lowest GCS. The majority of injuries sustained were head injuries followed by extremity fractures. Dressers and standard television stands were common supportive structures from which the television fell and injured the child. CONCLUSIONS These data show that the majority of television-related injuries occur in toddlers (1 to 3 years) who were left unattended at home. The mortality rate was surprisingly high, especially in children </= years from subsequent head injuries. Prevention focused on improved public awareness of this danger, and modified design of the standard support structures can decrease the number of injuries, which will benefit children overall.
Postindustrial Fertility Ideals, Intentions, and Gender Inequality: A Comparative Qualitative Analysis

Fertility ideals remain centered on two children in most postindustrial societies, presenting a puzzle for demographers interested in very low fertility. This paper explores the conditions producing a gap between fertility ideals and intentions among young highly-educated adults in different postindustrial contexts. We employ in-depth interviews to analyze reasoning about fertility ideals and intentions in two countries with very low fertility (Japan and Spain) and two with slightly higher fertility (the U.S. and Sweden). We find that American and Swedish female interviewees are more likely than those in Japan and Spain to cite work-family conflict as a reason for their ideals-intentions gap. Our results also suggest that gender inequality is more important in generating low fertility intentions among highly-educated interviewees in Japan than Spain. Taken together, these findings suggest complexities in how gender inequality affects fertility intentions among the highly-educated in postindustrial contexts.
Remaining Questions about Clinical Variola Major

After the recent summary of World Health Organization–authorized research on smallpox, several clinical issues remain. This policy review addresses whether early hemorrhagic smallpox is disseminated intravascular coagulation and speculates about the cause of the high mortality rate among pregnant women and whether ocular smallpox is partly the result of trachoma or vitamin A deficiency. The joint destruction common in children with smallpox might be prevented by antiviral drugs, but intraarticular infusion of antiviral drugs is unprecedented. Development of highly effective antiviral drugs against smallpox raises the issue of whether postexposure vaccination can be performed without interference by an antiviral drug. Clinicians should consider whether patients with smallpox should be admitted to general hospitals. Although an adequate supply of second-generation smallpox vaccine exists in the United States, its use is unclear. Finally, political and ethical forces suggest that destruction of the remaining stocks of live smallpox virus is now appropriate.
A nonpeptide integrin antagonist can inhibit epithelial cell ingestion of Streptococcus pyogenes by blocking formation of integrin alpha 5beta 1-fibronectin-M1 protein complexes.

Streptococcus pyogenes can be efficiently internalized by a variety of human epithelial cells. beta-lactam antibiotics, commonly used to treat S. pyogenes infections, do not readily permeate mammalian cells. There is growing evidence that the ability of streptococci to enter host cells contributes to the frequent failure of antibiotics to eradicate the organism from infected individuals. Recent studies have suggested that host cell entry requires the formation of a complex of a bacterial fibronectin (Fn) binding protein (e.g., M1 protein or protein F1/SfbI), human Fn, and the epithelial cell Fn receptor, integrin alpha5beta1. We report here that a low molecular weight, nonpeptide antagonist of integrin alpha5beta1, SJ755, can inhibit internalization of streptococci by primary human tonsillar epithelial cells and immortalized human epithelial (A549) cells, thus increasing the extent of bacterial killing by antibiotics. SJ755 blocked Fn binding by human tonsillar epithelial and A549 cells, suggesting that integrin alpha5beta1 is the major Fn receptor expressed by both cell types. SJ755 did not affect Fn binding by purified M1 protein or M1(+) bacteria. Purified M1 protein failed to associate with integrin alpha5beta1 unless the integrin had been prebound by Fn. Also, SJ755 blocked formation of alpha5beta1-Fn-M1 complexes in vitro. These results support the previous proposal that Fn functions as a molecular bridge between M1 protein and integrin alpha5beta1. Furthermore, these results suggest that integrin antagonists may enhance the efficacy of antibiotics in treatment of S. pyogenes infections.
K+ Channel TASK-1 Knockout Mice Show Enhanced Sensitivities to Ataxic and Hypnotic Effects of GABAA Receptor Ligands

TASK two-pore-domain leak K+ channels occur throughout the brain. However, TASK-1 and TASK-3 knockout (KO) mice have few neurological impairments and only mildly reduced sensitivities to inhalational anesthetics, contrasting with the anticipated functions and importance of these channels. TASK-1/-3 channel expression can compensate for the absence of GABAA receptors in GABAA α6 KO mice. To investigate the converse, we analyzed the behavior of TASK-1 and -3 KO mice after administering drugs with preferential efficacies at GABAA receptor subtypes: benzodiazepines (diazepam and flurazepam, active at α1βγ2, α2βγ2, α3βγ2, and α5βγ2 subtypes), zolpidem (α1βγ2 subtype), propofol (β2–3-containing receptors), gaboxadol (α4βδ and α6βδ subtypes), pregnanolone, and pentobarbital (many subtypes). TASK-1 KO mice showed increased motor impairment in rotarod and beam-walking tests after diazepam and flurazepam administration but not after zolpidem. They also showed prolonged loss of righting reflex induced by propofol and pentobarbital. Autoradiography indicated no change in GABAA receptor ligand binding levels. These altered behavioral responses to GABAergic drugs suggest functional up-regulation of α2β2/3γ2 and α3β2/3γ2 receptor subtypes in TASK-1 KO mice. In addition, female, but not male, TASK-1 KO mice were more sensitive to gaboxadol, suggesting an increased influence of α4βδ or α6βδ subtypes. The benzodiazepine sensitivity of TASK-3 KO mice was marginally increased. Our results underline that TASK-1 channels perform such key functions in the brain that compensation is needed for their absence. Furthermore, because inhalation anesthetics act partially through GABAA receptors, the up-regulation of GABAA receptor function in TASK-1 KO mice might mask TASK-1 channel's significance as a target for inhalation anesthetics.
Thermally robust atomic layer deposited ZrO2 gate dielectric films upon the post-deposition annealing

The effects of post-deposition annealing (PDA) on the electrical characteristics of ZrO<inf>2</inf> and HfO<inf>2</inf> gate dielectric films were investigated. After PDA at 600°C, the insulating properties of ZrO<inf>2</inf> were improved, while those of HfO<inf>2</inf> were deteriorated. The improved insulating properties of ZrO<inf>2</inf> are attributed to both the negligible increase of interfacial layer (IL) thickness and the transformation of its crystalline structure to the tetragonal phase. The degraded insulating properties of HfO<inf>2</inf> after PDA at high temperatures were due to the abrupt increase of IL thickness and the generation of current paths through grain boundaries. The different IL growth between HfO<inf>2</inf> and ZrO<inf>2</inf> after PDA could be understood from the different formation energy of oxygen interstitials in the two dielectric films.
An evaluation of the potential of polarimetric radiometry for numerical weather prediction using QuikSCAT

It has been proposed that wind vector information derived from passive microwave radiometry may provide an impact on numerical weather forecasts of similar magnitude to that achieved by scatterometers. Polarimetric radiometers have a lower sensitivity to wind direction than scatterometers at low wind speed but comparable sensitivity at high windspeed. In this paper, we describe an experiment which aimed to determine if an observing system only capable of providing wind direction information at wind speeds over 8 ms/sup -1/ can provide comparable impact to one providing wind vectors at wind speeds over 2 ms/sup -1/. The QuikSCAT dataset used in the experiments has a wide swath and is used operationally by several forecast centers. The results confirm that assimilation of wind vectors from QuikSCAT only for wind speeds above 8 ms/sup -1/ gives similar analysis increments and forecast impacts to assimilating wind vectors at all wind speeds above 2 ms/sup -1/. Measurements from the WindSat five frequency polarimetric radiometer are compared with calculations from Met Office global forecast fields, and this also confirms that WindSat measurement and radiative transfer model accuracy appears to be sufficiently good to provide useful information for numerical weather prediction.
Screening and treatment of Chlamydia trachomatis infections

#### Summary points Chlamydia trachomatis is the most commonly diagnosed bacterial sexually transmitted infection worldwide.1 2 Numbers of diagnoses have increased over the past 10 years as a result of more sensitive tests and increased testing. Genital infection with C trachomatis is asymptomatic in 50-88% of men and women,w1 and 46% of infections clear spontaneously within a year.3 #### Sources and selection criteria We searched Medline databases for Chlamydia trachomatis , chlamydia screening, pelvic inflammatory disease, and ectopic pregnancy. We looked at guidelines from the National Institute for Health and Clinical Excellence and the Scottish Intercollegiate Guidelines Network, in addition to reports from the European Centre for Disease Prevention and Control, the US Centers for Disease Control and Prevention, and World Health Organization. Persistent chlamydia infection can lead to pelvic inflammatory disease, ectopic pregnancy, and tubal infertility in womenw2 and epididymitis and epididymo-orchitis in men.2 Here, we describe the diagnosis and management of chlamydia and discuss control strategies. Guidance on the laboratory diagnosis and treatment of chlamydia has a strong evidence base, but evidence on the natural course of infection and optimum control strategies is less robust. Infection can occur at any age but is most common in people under 25,w3 with rates of diagnosis peaking …
A Review of Architectures and Concepts for Intelligence in Future Electric Energy Systems

Renewable energy sources are one key enabler to decrease greenhouse gas emissions and to cope with the anthropogenic climate change. Their intermittent behavior and limited storage capabilities present a new challenge to power system operators to maintain power quality and reliability. Additional technical complexity arises from the large number of small distributed generation units and their allocation within the power system. Market liberalization and changing regulatory framework lead to additional organizational complexity. As a result, the design and operation of the future electric energy system have to be redefined. Sophisticated information and communication architectures, automation concepts, and control approaches are necessary in order to manage the higher complexity of so-called smart grids. This paper provides an overview of the state of the art and recent developments enabling higher intelligence in future smart grids. The integration of renewable sources and storage systems into the power grids is analyzed. Energy management and demand response methods and important automation paradigms and domain standards are also reviewed.
[Cigarette smoking among medical students].

WE surveyed the cigarette-smoking habits of the 771 students in the University of Michigan Medical School, and correlated them with their personal opinions about the relation of cigarette smoking to carcinoma of the lung, pulmonary emphysema and coronary-artery disease. The findings are summarized in Table 1. Twenty-three per cent of the students were currently smoking cigarettes; 61.8 per cent had never habitually smoked. Both the smokers and the nonsmokers, in equally high percentages, believed that cigarette smoking could cause carcinoma of the lung. A significantly higher percentage of smokers than nonsmokers believed emphysema was causally related to cigarette smoking (p less .
Morbidity of parainfluenza 3 outbreak in preterm infants in a neonatal unit.

INTRODUCTION Parainfluenza type 3 virus (PIV-3) is an important nosocomial pathogen which causes pneumonia and bronchiolitis in infants. We report an outbreak of PIV-3 respiratory infection which occurred in the neonatal unit of KK Hospital in June 2005. This is the second PIV-3 outbreak in our unit after the fi rst in December 1994. MATERIALS AND METHODS The clinical characteristics and outcome of 7 infants tested positive for PIV-3 on nasopharyngeal aspirate in June 2005 were reviewed retrospectively. RESULTS Seven cases were infected with PIV-3 during this outbreak. The median birthweight of affected infants was 970 g (range, 740 to 2585 g), gestational age was 27 weeks and 4 days (range, 24 to 35 weeks), and postnatal age was 84 days (range, 28 to 250 days). Apnoeas and bradycardias were significant symptoms in 3 infants, 5 infants had progressive respiratory distress while the remaining 2 infants had flu-like illness. Five infants required ventilatory support and there were no deaths. The index case was an infant with chronic lung disease who was on oxygen supplementation and subsequently required ventilatory support with nasal CPAP. Despite implementation of control measures to prevent the spread of infection through early identification with strict cohorting of infected cases, contact tracing/screening, and reinforcement of hand hygiene precautions, the outbreak lasted for 24 days. CONCLUSION PIV-3 respiratory infection in preterm infants can present with non-specific symptoms, leading to significant morbidity especially in those with underlying pulmonary pathology. Early recognition of symptoms and diagnosis by physicians, and prompt institution of control measures are necessary to prevent the spread of infection.
A Visual Reporter System for Virus-Induced Gene Silencing in Tomato Fruit Based on Anthocyanin Accumulation1[C][W]

Virus-induced gene silencing (VIGS) is a powerful tool for reverse genetics in tomato (Solanum lycopersicum). However, the irregular distribution of the effects of VIGS hampers the identification and quantification of nonvisual phenotypes. To overcome this limitation, a visually traceable VIGS system was developed for fruit, comprising two elements: (1) a transgenic tomato line (Del/Ros1) expressing Antirrhinum majus Delila and Rosea1 transcription factors under the control of the fruit-specific E8 promoter, showing a purple-fruited, anthocyanin-rich phenotype; and (2) a modified tobacco rattle virus VIGS vector incorporating partial Rosea1 and Delila sequences, which was shown to restore the red-fruited phenotype upon agroinjection in Del/Ros1 plants. Dissection of silenced areas for subsequent chemometric analysis successfully identified the relevant metabolites underlying gene function for three tomato genes, phytoene desaturase, TomloxC, and SlODO1, used for proof of concept. The C-6 aldehydes derived from lipid 13-hydroperoxidation were found to be the volatile compounds most severely affected by TomloxC silencing, whereas geranial and 6-methyl-5-hepten-2-one were identified as the volatiles most severely reduced by phytoene desaturase silencing in ripening fruit. In a third example, silencing of SlODO1, a tomato homolog of the ODORANT1 gene encoding a myb transcription factor, which regulates benzenoid metabolism in petunia (Petunia hybrida) flowers, resulted in a sharp accumulation of benzaldehyde in tomato fruit. Together, these results indicate that fruit VIGS, enhanced by anthocyanin monitoring, can be a powerful tool for reverse genetics in the study of the metabolic networks operating during fruit ripening.
The Effect of Metal Concentration on the Parameters Derived from Complexometric Titrations of Trace Elements in Seawater—A Model Study

In this study we examine the impact of dissolved metal concentrations on the parameters that are commonly determined from complexometric titrations in seawater. We use the non-ideal competitive adsorption (NICA) model within the framework of the chemical speciation program visual MINTEQ with iron as a model metal. We demonstrate that dissolved iron concentrations effect the determined parameters for a heterogeneous binding site distribution with a fixed concentration of dissolved organic carbon. The commonly used terms ‘ligand concentration’ and ‘binding constant’ are therefore dependent on metal concentration, so we adopt the terminology suggested by Town and Filella (Limnology and Oceanography, 45, 1341-1357, 2000) and use the terms ligand quotient and stability quotient here. The systematic increase in the ligand quotient with dissolved iron concentration likely contributes towards the trend of increasing ligand quotient with dissolved iron concentration observed in field studies, and makes it hard to assign an objective meaning to the parameter. We suggest that calculation of the side reaction coefficient, a parameter that describes the probability that any added metal will be complexed, could be less prone to bias and misinterpretation than calculation of conditional stability and ligand quotients. We explore the impact of experimental design on side reaction coefficients by applying different detection windows, and multiwindow and reverse titration approaches. We identify the method that results in the best estimates of side reaction coefficients over a range of iron concentrations between 0.1 and 1.5 nmol L-1. We find that single window titrations can only reliably estimate side reaction coefficients over a limited range of iron concentrations. Multiwindow titrations provided estimates of side reaction coefficients within the 99 % confidence interval of the values calculated directly from the NICA model at all iron concentrations examined here. We recommend that future reports of speciation measurements consider the potential influence of metal concentrations on the determined parameters and future studies focus on developing and applying experimental designs that improve the robustness and rigor of chemical speciation analysis in the marine environment.
Anaplasma phagocytophilum Infection Induces Protracted Neutrophil Degranulation

ABSTRACT Anaplasma phagocytophilum-infected neutrophil degranulation could exacerbate inflammation. Thus, the degranulation of infected neutrophils was assayed. Infected neutrophils expressed CD11b and CD66b, and supernatants of infected neutrophils showed more proMMP-9 and MMP-9 activity than controls and continued to do so for ≥18 h. Degranulation-related inflammatory tissue injury may account for some clinical manifestations in human granulocytic anaplasmosis.
Studying Single-Trials of phase Synchronous Activity in the Brain

This paper introduces a new method, single-trial phase locking statistics (S-PLS) to estimate phase locking in single trials of brain signals between two electrodes. The possibility of studying single trials removes an important limitation in the study of long-range synchrony in brain signals. S-PLS is closely related to our previous method, phase locking statistics (PLS) that estimates phase locking over a set of trials. The S-PLS method is described in detail and applied to human surface recordings during the task of face-recognition. We compare these results with those provided by PLS and show that they are qualitatively very similar, although S-PLS provides better discrimination of synchronic episodes.