Miracle-dz/UniFAR-FTUs huggingface dataset:
Blind Identification of the Central Aortic Pressure Waveform from Multiple Peripheral Arterial Pressure Waveforms

We introduce a blind identification technique to reconstruct the clinically more relevant central aortic pressure waveform from multiple less invasively measured peripheral arterial pressure waveforms. We conducted initial testing of the technique in two swine in which peripheral arterial pressure waveforms from the femoral and radial arteries and reference central aortic pressure were simultaneously measured during diverse hemodynamic conditions. We report an overall error between the estimated and measured central aortic pressure waveforms of 4.8%. Potential clinical applications of the technique may include critical care monitoring with respect to invasive catheter systems and emergency and home monitoring with respect to non-invasive arterial pressure transducers
Protective effect of Mori Cortex radicis extract against high glucose-induced oxidative stress in PC12 cells

ABSTRACT This study was undertaken to investigate the neuroprotective effect of an ethanolic extract of Mori Cortex radicis (MCR) against high glucose (HG)-induced oxidative damage in PC12 cells. Cell cytotoxicity was examined using MTT and lactate dehydrogenase assays. To examine the antioxidative effects, intracellular reactive oxygen species (ROS) and malondialdehyde (MDA) levels and the activities of antioxidant enzymes were measured. The expressions of apoptosis-associated proteins were assessed. MCR was found to increase the viabilities of HG-induced PC12 cells and to inhibit ROS and MDA production and to promote antioxidative enzyme activities. Furthermore, MCR reduced apoptosis by upregulating p-Akt and Bcl-2/Bax ratio and reducing cytochrome c level. The main flavonoids in MCR were identified by HPLC to be kuwanon G and morusin. These results suggest the antioxidative effects of MCR protect against HG-induced oxidative stress and that MCR has potential therapeutic use for the prevention and treatment of diabetic neuro-degeneration. Graphical abstract Protective effect of MCR against HG-induced oxidative stress and its major compounds kuwanon G and morusin
Clinical Outcomes of Stereotactic Radiosurgery for Cerebral Arteriovenous Malformations in Pediatric Patients: Systematic Review and Meta-Analysis.

BACKGROUND Arteriovenous malformations (AVMs) in pediatric patients exhibit remarkable differences in terms of management and outcomes. Owing to a paucity of relevant data pertaining to AVMs in pediatric patients, special interest and investigation are required for an improved understanding of the available evidence by clinicians. OBJECTIVE To determine the clinical outcomes of single-session stereotactic radiosurgery (SRS) for AVMs in pediatric patients. METHODS A systematic literature review was performed to identify studies that reported the outcomes of SRS for AVMs in pediatric patients. Data pertaining to variables such as obliteration rate, post-SRS new hemorrhage rate, post-SRS new neurological deficit rate, and mortality rate were extracted and analyzed using meta-analysis techniques. RESULTS Based on pooled data from 20 studies with 1212 patients, single-session SRS resulted in complete obliteration in 65.9% (95% confidence interval [CI], 60.5%-71.1%; I2 = 66.5%) patients. Overall complication rate (including new hemorrhage, new neurodeficit, and mortality) was 8.0% (95% CI, 5.1%-11.5%; I2 = 66.4%). Post-SRS new neurological deficit rate was 3.1% (95% CI, 1.3%-5.4%; I2 = 59.7%), and post-SRS hemorrhage rate was 4.2% (95% CI, 2.5%-6.3%; I2 = 42.7%). There was no significant difference between studies disaggregated by treatment method (Gamma Knife [Elekta AB] vs other), treatment year (before year 2000 vs after year 2000), median AVM volume reported (≥3 vs <3 cm3), median dose reported (≥20 vs <20 Gy), or follow-up period (≥36 vs <36 mo). CONCLUSION Single-SRS is a safe treatment alternative that achieves high obliteration rates and acceptable complication rates for AVMs in pediatric patients.
Systematic review of shift work and nurses' health.

BACKGROUND Nursing is characterized by a working articulation in shifts to ensure continuity of care throughout the 24 h. However, shift work and the resulting desynchronization of circadian rhythms may have adverse effects on nurses' health. AIMS To describe the effects of shift work and desynchronization of circadian rhythms on nurse's health. METHODS Databases: PubMed, Cinahl, Scopus, Embase and Ilisi. Search terms (free terms, MeSH): 'nurses', 'shiftwork', 'nightwork', 'sleep disorder, circadian rhythm', 'work schedule tolerance', 'breast neoplasm', 'metabolic syndrome X', 'metabolic cardiovascular syndrome', 'Cardiovascular disease', 'stress', 'diabetes'. We included all randomized controlled trials, observational studies, reviews and papers studying nurses' shift work. Quality assessment of the retrieved papers was verified according to Dixon-Woods checklist. RESULTS Twenty-four articles were analyzed. Literature review has shown that shift work involves an alteration in psychophysical homeostasis, with a decrease in performance. It is an obstacle for social and family relationships, as well as a risk factor for stress, sleep disorders, metabolic disorders, diabetes, cardiovascular disorders and breast cancer. CONCLUSIONS An organized ergonomic turnaround can be less detrimental to the health of nurses and more beneficial for the healthcare providers. Therefore, we suggest organizing studies to assess whether improving nurses' health would lead to a reduction in miscarriages, absenteeism and work-related stress.
Stress Steroid Levels and the Short-Term Impact of Routine Dehorning in Female Southern White Rhinoceroses (Ceratotherium simum simum)

Rhinoceros populations in Africa are under severe threat as a result of surging poaching rates and risk-mitigation strategies are continuously adapted in an attempt to ensure the survival of the species. This study compared faecal glucocorticoid metabolite (fGCM) levels of two age classes of limited free-ranging female white rhinos with fGCM levels of adult free-ranging female white rhinos. Subsequently, fGCM alterations in the limited free-ranging animals were monitored following routine dehorning as a measure of the animals' short-term physiological stress response. Baseline fGCM levels differed significantly between tested groups, with both free-ranging and limited free-ranging adult animals showing significantly higher fGCM levels compared with limited free-ranging juvenile females. In contrast, baseline fGCM levels did not differ significantly between limited free-ranging and free-ranging adult individuals. Routine dehorning procedures resulted in a short-term stress response expressed by a significant increase in fGCM levels 48 h post-dehorning, with stress steroid levels returning to pre-dehorning concentrations 72 h after the procedure.
Herbivore resistance in congeneric and sympatric Nothofagus species is not related to leaf habit.

PREMISE Two fundamental hypotheses on herbivore resistance and leaf habit are the resource availability hypothesis (RAH) and the carbon-nutrient balance hypothesis (CNBH). The RAH predicts higher constitutive resistance by evergreens, and the CNBH predicts higher induced resistance by deciduous species. Although support for these hypotheses is mixed, they have rarely been examined in congeneric species. METHODS We compared leaf constitutive and induced resistance (as leaf polyphenol and tannin concentrations, and as damage level in non-choice experiments) and leaf traits associated with herbivory of coexisting Nothofagus species using (1) a defoliation experiment and (2) natural defoliation caused by an outbreak of a common defoliator of Nothofagus species. RESULTS In the defoliation experiment, polyphenol and tannin concentrations were similar between deciduous and evergreen species; regardless of leaf habit, polyphenols increased in response to defoliation. In the natural defoliation survey, N. pumilio (deciduous) had significantly higher herbivory, lower carbon/nitrogen ratio and leaf mass per area, and higher nitrogen and phosphorus concentrations than N. betuloides (evergreen); N. antarctica (deciduous) had intermediate values. Polyphenol concentrations and herbivore resistance indicated by the non-choice experiment were lower in N. pumilio than in N. antarctica and N. betuloides, which had similar values. CONCLUSIONS Higher herbivory in N. pumilio was associated with a higher nutritional value and a lower level of leaf carbon-based defenses compared to both the evergreen and the other deciduous species, indicating that herbivore resistance in Nothofagus species cannot be attributed to only leaf habit as predicted by the RAH or CNBH.
Evidence for the genetic basis and epistatic interactions underlying ocean‐ and river‐maturing ecotypes of Pacific Lamprey (Entosphenus tridentatus) returning to the Klamath River, California

Surveys of genomic variation have improved our understanding of the relationship between fitness‐related phenotypes and their underlying genetic basis. In some cases, single large‐effect genes have been found to underlie important traits; however, complex traits are expected to be under polygenic control and elucidation of multiple gene interactions may be required to fully understand the genetic basis of the trait. In this study, we investigated the genetic basis of the ocean‐ and river‐maturing ecotypes in anadromous Pacific lamprey (Entosphenus tridentatus). In Pacific lamprey, the ocean‐maturing ecotype is distinguished by advanced maturity of females (e.g., large egg mass) at the onset of freshwater migration relative to immature females of the river‐maturing ecotype. We examined a total of 219 adult Pacific lamprey that were collected at‐entry to the Klamath River over a 12‐month period. Each individual was genotyped at 308 SNPs representing known neutral and adaptive loci and measured at morphological traits, including egg mass as an indicator of ocean‐ and river‐maturing ecotype for females. The two ecotypes did not exhibit genetic structure at 148 neutral loci, indicating that ecotypic diversity exists within a single population. In contrast, we identified the genetic basis of maturation ecotypes in Pacific lamprey as polygenic, involving two unlinked gene regions that have a complex epistatic relationship. Importantly, these gene regions appear to show stronger effects when considered in gene interaction models than if just considered additive, illustrating the importance of considering epistatic effects and gene networks when researching the genetic basis of complex traits in Pacific lamprey and other species.
Essays on the effects of home legal institutions and the Sarbanes-Oxley Act on foreign IPOs in the US

The objective of this thesis is to investigate the role of home country legal institutions and the Sarbanes-Oxley Act (SOX) on the reporting quality, pricing and performance of foreign initial public offerings (IPOs) in US capital markets. The specific characteristics of foreign IPOs as have been recognized within the recently expanding literature on cross-listed firms make the focus of this research highly interesting and relevant given the growing number of firm that chose to make their initial public offering in foreign markets, typically the US markets. Using a unique dataset of foreign issuers in the US, this thesis addresses some of the unresolved issues of the impact of institutional differences on information asymmetry in foreign IPOs. To do this, I look at different agency problems over the life cycle of new issuers. Specifically, the first empirical study of this thesis explores the earnings quality in foreign IPOs in the US and the relation to home country institutions. The second empirical study of this thesis investigates the effects of the home country institutions on the level of underpricing of foreign IPOs in the US, and whether underpricing is significantly different after the enactment of SOX. The third empirical study investigates the effects of the home country institutions on the long-run stock performance of foreign IPOs in the US, and whether performance is significantly different post the enactment of SOX. The main findings of this thesis suggest that home country legal institutions matter to the reporting characteristics, to the costs of capital at the initial listing date and to the aftermarket stock performance of foreign IPOs in the US. Furthermore, there is mixed evidence regarding the effects of SOX on the reporting characteristics, to the cost of capital at the initial listing date and to the aftermarket stock performance. In contrast with some previous research on cross-listed firms, the results of this study suggest that although foreign IPOs may abandon their home capital markets by listing in the US, their reporting characteristics and costs of capital are nonetheless influenced by home country institutions.
What Happens During the Private Period?: Evidence from Public‐To‐Private Reverse LBOs

This study provides new evidence on the restructuring activities undertaken by public‐to‐private reverse leveraged buyouts (RLBOs) while owned by private equity firms. The authors' comprehensive sample of public‐to‐private LBOs that return to public ownership through IPOs enables them to observe changes in profitability, valuation, financial structure, operating structure, and cost structure from the time the firms go private through (and after) their emergence through (re‐) IPOs. With their exclusive focus on reverse LBOs involving public‐to‐private deals, the authors reach findings that contradict previous conclusions about RLBOs. At the time of the LBO, the target firms in reverse LBOs are more levered than their peers, pay higher dividends, and are more profitable than their peers. At the same time, however, they appear to have lower market valuations before the buyouts. During the private period, the target firms of reverse LBOs achieve significant increases in employee productivity, asset restructuring, and improved gross margins, while operating with substantially higher levels of debt financing, lower levels of cash and working capital, and greater concentration of equity ownership. After the companies return to public ownership through IPOs, such companies continue to operate with higher leverage and ownership concentration than their publicly traded peers while producing further increases in profitability, resulting in substantial increases in both enterprise and equity valuation. The authors' analysis also shows that higher debt levels from the buyout play an important role in increased enterprise values. The evidence suggests that possible undervaluation as well as expected efficiency gains from restructuring actions are the primary motives for such reverse LBOs.
Nutrigenetic Testing for Personalized Nutrition: An Evaluation of Public Perceptions, Attitudes, and Concerns in a Population of French Canadians

Background/Aims: This study aimed to evaluate attitudes, perceptions, and concerns about nutrigenetic testing for personalized nutrition in the general population of the province of Quebec in Canada. Methods: A total of 1,425 individuals from the province of Quebec completed a 37-question online survey on nutrigenetics and were included in analyses. The χ2 test was used to test for associations between categorical variables. Results: The majority of the participants (93.3%) considered dietitians the best professionals to give personalized dietary advice based on nutrigenetic testing. The main reported advantage for nutrigenetic testing was “health” (23.5%), followed by “disease prevention” (22.2%). Among the disadvantages, “no disadvantage” (24.4%), followed by “diet restriction” (12.9%) were mostly reported. The 2 major concerns raised were accessibility to genetic testing by telemarketing companies and spammers (51.8%), and solicitation by companies using personal genetic data to sell products (48.6%). Conclusions: French Canadians generally have a positive attitude towards nutrigenetics and consider its use to have many benefits. They expressed concern about possible confidentiality issues associated with the management or property of genetic test results. Education about such issues is needed. Overall, our findings suggest that the population is interested in more extensive use of nutrigenetics in health management.
Effects of Phytase Supplementation to Diets with or without Zinc Addition on Growth Performance and Zinc Utilization of White Pekin Ducks

Simple Summary The environment sustainability of farms is extremely important for the future of the world. In this context, the lowering of the pollution from intensive poultry farms is necessary. Due to its low levels and low digestibility in feeds, Zn is often overdosed in poultry feed, and its excess in the excreta can accumulate in the soil, inhibiting the growth of soil microorganism as well as altering their morphology and metabolism, thus reducing the crop yield and quality. Enzymes, such as phytase, can breakdown the linkage of Zn with phytic acid in vegetable feeds, thus increase the Zn availability for animal digestion. In this way, very low supplementation of Zn to the diets can meet the requirement of poultry. Abstract The effect of phytase and inorganic Zn supplementation was studied in 180 male White Pekin ducks (WPD) from 1 to 56 days of age. The birds were divided into four groups fed the same basal diet (containing 26 ppm of Zn from raw materials): the control group did not receive Zn supplementation; the second group was supplemented with 30 ppm of Zn oxide; and the third and fourth groups were fed the control and the 30 ppm diets, respectively, both supplemented with 500 U of E. coli phytase. Each group contained five replicates of nine ducks. The body weight and feed intake were recorded at 1, 28 and 56 days of age. At 56 days of age, five birds/group were used to measure feed digestibility and five other birds/group were slaughtered. Zn at 30 ppm increased the body weight gain (BWG, p < 0.01) and feed intake (p < 0.05) and improved the feed conversion (FCR, p < 0.05) of the growing ducks. The Zn retention and Zn level in the excreta increased (p < 0.01) due to Zn supplementation. The addition of phytase improved BWG (p < 0.01) and FCR (p < 0.05) of growing ducks. The use of phytase reduced (p < 0.01) the level of Zn in duck excreta. Phytase supplementation to the basal diet at 30 ppm seems to be adequate to meet Zn requirements for ducks without further Zn additions.
Sentiment Contagion, Corporate Governance, Information and Legal Environments

This paper studies impacts of US investor sentiment on non-US stock returns across 38 developed and developing equity markets. Employing data from 1977 to 2004, we find that US sentiment strongly influences future returns for various long-short portfolios designed to reflect sentiment prone stocks. The sentiment contagion is unlikely to be fully explained by the asset holdings of international investors. We find that the sentiment contagion is generally and significantly stronger when the information and legal environments are of high quality. We further document strong evidence that good corporate governance environments help diminish the spread of US investor sentiment across stock markets. Our results also suggest higher correlation for stocks with similar levels of sentiment sensitivity, such as small and high growth stocks, across markets, which will tend to reduce international diversification benefits.
Physician View and Experience of the Diagnosis of Autism Spectrum Disorder in Young Children

Introduction: Clinicians working with children with autism spectrum disorder (ASD) occupy an important position between parents and the wide-ranging research findings. However, it is not widely known how clinicians view and experience ASD in children, even though their perspective has been shown to significantly influence their work. Material and methods: Sixteen physicians working with preschool children without a diagnosis of (intellectual or other) disability with a (presumed) diagnosis of ASD participated in a semistructured interview. They described their professional views on ASD, and how they experienced its use in their clinical practice. The data were analyzed by applying the qualitative research method of interpretative phenomenological analysis of the data through Nvivo 11. Results: The main topic of the interviewed physicians’ views and experiences of ASD in a young child comprised three inductively established themes: 1) physicians’ views on ASD are multifaceted but fit within their personal clinical styles; 2) the ASD diagnosis is a “descriptive” part of a clinical trajectory; and 3) ASD treatment is a mix of “standard” approaches and a personalized search. These physicians’ perspectives on ASD are composed of multiple and sometimes ambiguous facets. However, their views are embedded in their personal clinical styles in general (i.e., beyond ASD) and are experienced as clinically “workable. ” With the aim of finding an adequate approach to the problems parents bring to their office, many interviewed physicians say that—complementary to or rather than a classificatory diagnosis—they prefer using a personalized “profile” of a child in a therapeutic “process. ” Conclusions: The interviewed physicians consider doubts and concerns to be an inherent part of their clinical work with ASD in young children, but do not experience this ambiguity as an obstacle to clinical care. These physicians deal with the multiplicity of their views on ASD by basing their eclectic views on their generally adopted clinical styles, and by selecting what works for them, and for the parents and child, from what they regard as the ‘textbook knowledge’ on ASD. We discuss the implications of these findings for translating research results to the clinic.
Genetic and Environmental Effects on Weight, Height, and BMI Under 18 Years in a Chinese Population-Based Twin Sample

This study examined the genetic and environmental effects on variances in weight, height, and body mass index (BMI) under 18 years in a population-based sample from China. We selected 6,644 monozygotic and 5,969 dizygotic twin pairs from the Chinese National Twin Registry (CNTR) aged under 18 years (n = 12,613). Classic twin analyses with sex limitation were used to estimate the genetic and environmental components of weight, height, and BMI in six age groups. Sex-limitation of genetic and shared environmental effects was observed, especially when puberty begins. Heritability for weight, height, and BMI was low at 0–2 years old (less than 20% for both sexes) but increased over time, accounting for half or more of the variance in the 15–17 year age group for boys. For girls, heritabilities for weight, height and BMI was maintained at approximately 30% after puberty. Common environmental effects on all body measures were high for girls (59–87%) and presented a small peak during puberty. Genetics appear to play an increasingly important role in explaining the variation in weight, height, and BMI from early childhood to late adolescence, particularly in boys. Common environmental factors exert their strongest and most independent influence specifically in the pre-adolescent period and more significantly in girls. These findings emphasize the need to target family and social environmental interventions in early childhood years, especially for females. Further studies about puberty-related genes and social environment are needed to clarify the mechanism of sex differences.