Miracle-dz/UniFAR-FTUs huggingface dataset:
Mapping the World’s Largest Democracy (1947–2017)

Abstract After seven decades as an independent democratic nation, India’s social landscape remains marred by persistent contradictions and inequalities. As the country moves from celebrating 70 years of independence towards its seventeenth general election in 2019, this article sets out to survey what democracy has done to India over the past 70 years. How was Indian democracy established and how has it evolved? Why do people vote, and who do they vote for? How does Indian democracy function beyond elections, and to what extent has democracy delivered in terms of social development and the economic and political integration of marginalized groups? These are the key questions that we address in this article. Drawing on Heller’s distinction between the formal, effective, and substantive dimensions of democracy, we adopt an understanding of the dynamics of Indian democracy that extends well beyond formal institutions and elections. While we acknowledge that Indian democracy in the formal sense is plural, vibrant, and resilient, we also argue that the transition from a vibrant formal democracy to one that is both effective and substantive is impeded by contradictions and inequalities that are both historical and contemporary in nature. We also reflect on the current potential of popular mobilizations from below for forging mutually reinforcing connections between the formal, effective, and substantive dimensions of democracy, in a context in which an increasingly authoritarian Hindu nationalism continues to gain ground.
Degradation of the Retinoblastoma Tumor Suppressor by the Human Papillomavirus Type 16 E7 Oncoprotein Is Important for Functional Inactivation and Is Separable from Proteasomal Degradation of E7

ABSTRACT The steady-state level and metabolic half-life of retinoblastoma tumor suppressor protein pRB are decreased in cells that express high-risk human papillomavirus (HPV) E7 proteins. Here we show that pRB degradation is a direct activity of E7 and does not reflect a property of cell lines acquired during the selection process for E7 expression. An amino-terminal domain of E7 that does not directly contribute to pRB binding but is required for transformation is also necessary for E7-mediated pRB degradation. Treatment with inhibitors of the 26S proteasome not only blocks E7-mediated pRB degradation but also causes the stabilization of E7. Mutagenic analyses, however, reveal that the processes of proteasomal degradation of E7 and pRB are not linked processes. HPV type 16 E7 also targets the pRB-related proteins p107 and p130 for destabilization by a proteasome-dependent mechanism. Using the SAOS2 flat-cell assay as a biological indicator for pRB function, we demonstrate that pRB degradation, not solely binding, is important for the E7-induced inactivation of pRB.
Metabolism of Arsenic Trioxide in Acute Promyelocytic Leukemia Cells

Arsenic trioxide (As2O3) effectively induces complete clinical and molecular remissions in acute promyelocytic leukemia (APL) patients and triggers apoptosis in APL cells. The effect induced by As2O3 is also associated with extensive genomic‐wide epigenetic changes with large‐scale alterations in DNA methylation. We investigated the As2O3 metabolism in association with factors involved in the production of its methylated metabolites in APL‐derived cell line, NB4. We used high performance liquid chromatography (HPLC) technique to detect As2O3 metabolites in NB4 cells. The effects of As2O3 on glutathione level, S‐Adenosylmethionine (SAM) and S‐adenosylhomocysteine (SAH) levels were investigated. Also, we studied the expression levels of arsenic methyltransferase (AS3MT) and DNA methyltransferases (DNMT1, DNMT3a, and DNMT3b) by real‐time PCR. Our results show that after As2O3 entry into the cell, it was converted into methylated metabolites, mono‐methylarsenic (MMA) and dimethylarsenic (DMA). The glutathione (GSH) production was increased in parallel with the methylated metabolites formations. As2O3 treatment inhibited DNMTs (DNMT1, DNMT3a, and DNMT3b) in dose‐ and time‐dependent manners. The SAH levels in As2O3‐treated cells were increased; however, the SAM level was not affected. The present study shows that APL cell is capable of metabolizing As2O3. The continuous formation of intracellular methylated metabolites, the inhibition of DNMTs expression levels and the increase of SAH level by As2O3 biotransformation would probably affect the DNMTs‐methylated DNA methylation in a manner related to the extent of DNA hypomethylation. Production of intracellular methylated metabolites and epigenetic changes of DNA methylation during As2O3 metabolism may contribute to the therapeutic effect of As2O3 in APL. J. Cell. Biochem. 115: 1729–1739, 2014. © 2014 Wiley Periodicals, Inc.
A1S_2811, a CheA/Y‐like hybrid two‐component regulator from Acinetobacter baumannii ATCC17978, is involved in surface motility and biofilm formation in this bacterium

Two‐component systems in Acinetobacter baumannii are associated with its virulence, drug resistance, motility, biofilm formation, and other characteristics. In this study, we used RecAb, a genetic engineering method, to investigate the function of A1S_2811 in A. baumannii strain ATCC17978. A1S_2811, a hypothetical hybrid sensor histidine kinase/response regulator, has four histidine‐containing phosphotransfer domains, a CheA‐like regulatory domain, and a CheY‐like receiver domain at its C terminus. Compared with the ATCC17978 strain, both surface motility and biofilm formation at the gas–liquid interface decreased significantly in the A1S_2811 knock‐out strain. The number of pilus‐like structures and the amount of extrapolymeric substances on the cell surface also decreased in the A1S_2811 null strain. Transcription of abaI, which encodes an N‐acylhomoserine lactone synthase in A. baumannii , decreased significantly in the A1S_2811 null strain, and supplementation with synthetic N‐(3‐oxodecanoyl) homoserine‐l‐lactone rescued the surface motility and biofilm formation phenotype in the null mutant. We speculate that A1S_2811 regulates surface motility and biofilm formation, not by regulating type IV pili‐associated genes expression, but by regulating the chaperone/usher pili‐associated csuA/ABCDE operon and the AbaI‐dependent quorum‐sensing pathway‐associated A1S_0112‐0119 operon instead.
Funny Evidence: Female Comics are the New Policy Entrepreneurs

The last decade has seen on-going issues of gender inequity as well as arguably the golden age of female comics. From Tina Fey and Amy Poehler’s renditions of Sarah Palin and Hillary Clinton in 2008, to Amy Schumer’s critique of US college rape culture, this is an extraordinary time to consider the role of female comics in policy making. This article will examine this period by locating these comedic skills within the policy entrepreneur literature. First, it will review policy entrepreneurship elements; secondly it will propose a framework for policy entrepreneurship that builds on intersectional feminist principles. Lastly, it will apply the framework to female comic’s influence on political issues. In all, we argue that female comics can serve as policy entrepreneurs in public administration by using their identity to locate themselves as relevant actors, attaching solutions to problems, biasing political outcomes, benefiting from their engagement, and introducing narratives that change the emotional habitus of an audience and influence the broader public.
Reliability of Emerging Bonded Interface Materials for Large-Area Attachments

Conventional thermal interface materials (TIMs), such as greases, gels, and phase change materials, pose bottlenecks to heat removal and have long caused reliability issues in automotive power electronics packages. Bonded interface materials (BIMs) with superior thermal performance have the potential to be a replacement to the conventional TIMs. However, due to coefficient of thermal expansion mismatches between different components in a package and resultant thermomechanical stresses, fractures or delamination could occur, causing serious reliability concerns. These defects manifest themselves in increased thermal resistance in the package. In this paper, the results of reliability evaluation of emerging BIMs for large-area attachments in power electronics packaging are reported. Thermoplastic (polyamide) adhesive with embedded near-vertical-aligned carbon fibers, sintered silver, and conventional lead solder (Sn63Pb37) materials were bonded between 50.8 mm x 50.8 mm cross-sectional footprint silicon nitride substrates and copper base plate samples, and were subjected to accelerated thermal cycling until failure or 2500 cycles. Damage in the BIMs was monitored every 100 cycles by scanning acoustic microscopy. Thermoplastic with embedded carbon fibers performed the best with no defects, whereas sintered silver and lead solder failed at 2300 and 1400 thermal cycles, respectively. Besides thermal cycling, additional lead solder samples were subjected to thermal shock and thermal cycling with extended dwell periods. A finite element method (FEM)-based model was developed to simulate the behavior of lead solder under thermomechanical loading. Strain energy density per cycle results were calculated from the FEM simulations. A predictive lifetime model was formulated for lead solder by correlating strain energy density results extracted from modeling with cycles-to-failure obtained from experimental accelerated tests. A power-law-based approach was used to formulate the predictive lifetime model.
Protective ventilation attenuates postoperative pulmonary dysfunction in patients undergoing cardiopulmonary bypass.

OBJECTIVE To ascertain if protective ventilation can attenuate the damaging postoperative pulmonary effects of cardiopulmonary bypass (increases in airway pressure, decreases in lung compliance, and increases in shunt). DESIGN Prospective, randomized clinical trial. SETTING Single university hospital. PARTICIPANTS Twenty-five patients undergoing elective coronary artery bypass graft procedure and early extubation. INTERVENTIONS Thirteen patients received conventional mechanical ventilation (CV; respiratory rate, 8 breaths/min; tidal volume, 12 mL/kg; fraction of inspired oxygen [FIO2], 1.0; positive end-expiratory pressure [PEEP], +5), and 12 patients received protective mechanical ventilation (PV; respiratory rate, 16 breaths/min; tidal volume, 6 mL/kg; FIO2, 1.0; PEEP, +5). Perioperative anesthetic and surgical management were standardized. Various pulmonary parameters were determined twice perioperatively: 10 minutes after intubation and 60 minutes after arrival in the intensive care unit. MEASUREMENTS AND MAIN RESULTS The mean postoperative increase in peak airway pressure in group CV was significantly larger than the mean postoperative increase in peak airway pressure in group PV (7.1 v 2.4 cm H2O; p < 0.001). Group CV experienced significant postoperative increases in plateau airway pressure (p = 0.007), but group PV did not (p = 0.644). The mean postoperative decrease in dynamic lung compliance in group CV was significantly larger than the mean postoperative decrease in dynamic lung compliance in group PV (14.9 v 5.5 mL/cm H2O; p = 0.002). Group CV experienced significant postoperative decreases in static lung compliance (p = 0.014), but group PV did not (p = 0.645). Group CV experienced significant postoperative increases in shunt (15.5% to 21.4%; p = 0.021), but group PV did not (18.4% to 21.2%; p = 0.265). CONCLUSIONS Data indicate that protective ventilation decreases pulmonary damage caused by mechanical ventilation in normal and abnormal lungs. The results of this investigation indicate that protective ventilation may also help attenuate the postoperative pulmonary dysfunction (increases in airway pressure, decreases in lung compliance, and increases in shunt) commonly seen in patients after exposure to cardiopulmonary bypass.
Influences of Housing Systems and Slaughter Weight on the Market Realization of Slaughter Pigs by SEUROP Classification

SLÁDEK LIBOR, MIKULE VLADIMÍR. 2018. Influences of Housing Systems and Slaughter Weight on the Market Realization of Slaughter Pigs by SEUROP Classification. Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 66(2): 389 – 397. The aim of the study was to evaluate an influence of housing technology and slaughter weight of slaughter pigs on realization with SEUROP system. Slaughter pigs of hybrid combination (Czech Large White × Czech Landrace) × Duroc were studied for reasons of an experiment. Analysed were 733 pigs. Slaughter pigs fattened on deep-bedded pens reached higher slaughter weight, higher back fat thickness, higher muscle deep, higher price per 1 kg of slaughter weight in comparison with pigs on slatted floor pens, but on the contrary they reached a lower portion of lean meat. These data were determined in pigs on deep-bedded pens: 117.58 kg slaughter weight, 16.78 mm of back fat thickness, 61.30 mm of muscle deep, 55.53 % of lean meat portion and price 32.15 Kč per 1 kg of slaughter weight. These data were determined in pigs reared on slatted floor pens: 110.82 kg slaughter weight, 14.38 mm of back fat thickness, 56.67 mm of muscle deep, 57.11 % of lean meat portion and price 31.86 Kč per 1 kg of slaughter weight. A statistical conclusive difference on a level of importance P ≤ 0.01 was found between pigs bred on deep-bedded pens and on slatted floor pens in traits slaughter weight, back fat thickness, muscle deep and meatiness. From experiment it is obvious that for 1 kg of slaughter weight in all business classes SEUROP higher price was in pigs fattened on deep-bedded pens in comparison with pigs fattened on slatted floor pens.
Increasing Hyperscale Data Center Efficiency: A Better Way to Manage 54-V\/48-V-to-Point-of-Load Direct Conversion

The hyperspeed growth of data center power demand starts with the high power consumption required by the current and upcoming generations of digital application-specific integrated circuits (ASICs)-central processing unit (CPU), double data rate memories (DDR) and networking ASICs-in addition to the exploding use of high-power graphics processing units (GPUs) for artificial intelligence and machine-learning functions. Hyperscale data centers will also increase in number, from 259 at the end of 2015 to 485 by 2020. They will represent 47% of all installed data center servers by 2020 [1]. Server shipment growth has been driven by large, hyperscale data centers, where servers are often configured for maximum productivity and operate at high utilization rates. Server power consumption is perpetually escalating, and this trend will continue into the near future for both midrange and high-end power servers [2], as shown in Figure 1.
Pulsed and continuous wave mobile phone exposure over left versus right hemisphere: Effects on human cognitive function

The possible effects of continuous wave (CW) and pulse modulated (PM) electromagnetic field (EMF) on human cognition was studied in 36 healthy male subjects. They performed cognitive tasks while exposed to CW, PM, and sham EMF. The subjects performed the same tasks twice during each session; once with left‐sided and once with right‐sided exposure. The EMF conditions were spread across three testing sessions, each session separated by 1 week. The exposed hemisphere, EMF condition, and test order were counterbalanced over all subjects. We employed a double‐blind design: both the subject and the experimenter were unaware of the EMF condition. The EMF was created with a signal generator connected via amplifier to a dummy phone antenna, creating a power output distribution similar to the original commercial mobile phone. The EMF had either a continuous power output of 0.25 W (CW) or pulsed power output with a mean of 0.25 W. An additional control group of 16 healthy male volunteers performed the same tasks without any exposure equipment to see if mere presence of the equipment could have affected the subjects' performance. No effects were found between the different EMF conditions, separate hemisphere exposures, or between the control and experimental group. In conclusion, the current results indicate that normal mobile phones have no discernible effect on human cognitive function as measured by behavioral tests. Bioelectromagnetics 28:289–295, 2007. © 2007 Wiley‐Liss, Inc.
Slovenian Adaptation of the Original Audit-C Questionnaire

Background: Alcohol Use Disorders Identification Test Consumption (AUDIT-C) questionnaire as a screening instrument for identification of hazardous and harmful drinkers give some false-positive and negative results. Changes of answers decrease the number of false results. Methods: Changes in second and third questions with theoretical simulation of possible answers’ combinations was made; cutoff scores have to be changed. Study with original and adapted AUDIT-C was conducted among 298 students to analyze the differences. Results: Adapted Slovenian version of AUDIT-C gives less false-positive and less false-negative results. Conclusions: Changes of AUDIT-C questionnaire that give less false results means less potential disharmony in doctor–patient relationship, less unnecessary questioning, less time spent inadequately, and also less missed hazardous drinkers.
Studies of platelet volume, chemistry and function in patients with essential thrombocythaemia treated with Anagrelide

Anagrelide (imidazoquinazolin derivative) is a new compound proposed for the treatment of myeloproliferative disorders. In this study, Anagrelide was given to patients with essential thrombocythaemia (ET) in a compassionate‐use protocol. The aim of this study was to test the effect of this drug not only on the platelet count but also on platelet volume, chemistry and function, which has not previously been reported. Thus, in ET, different functional or structural platelet abnormalities were reported: a shortening of the bleeding time, hypoaggregation to several agonists, and in particular a lack of response to adrenalin, an increase in the amount of total platelet glycoprotein IV (or CD36), and an abnormal migration of thrombospondin on electrophoresis. These different parameters were studied before and during therapy with Anagrelide. Although the platelet count was corrected, no functional or chemical abnormality was improved. Furthermore, platelet volume was shown to be constantly increased under Anagrelide. Thus, Anagrelide, in reducing the platelet count, may possibly decrease the risk of thrombosis and haemorrhage. Nevertheless, if the risk of thromboses and/or myelofibrosis is related not only to the platelet count but also to the platelet abnormalities, the persistence of a thrombocytopathy in patients treated with Anagrelide must be taken in consideration. Our data suggest that thromboses and myelofibrosis are clinical end‐points which should be included in future large‐scale use of Anagrelide.
Countercyclical School Attainment and Intergenerational Mobility

We study how economic conditions at the time of choosing post-compulsory education affect intergenerational mobility. Exploiting local variation in birthplace unemployment rate at age 16 across 23 cohorts in France, we find that cohorts deciding on post-compulsory education in bad economic times are more educationally mobile - their level of education is less related to having a white-collar father. These cohorts are also more occupationally mobile; and a large fraction of this effect is explaiend by business cycle-induced differences in educational attainment. Accounting for differential spatial mobility between birth and age 16 by parental background confirms the results.
GABA receptors and prepulse inhibition of acoustic startle in mice and rats

The acoustic startle reflex is strongly inhibited by a moderate‐intensity acoustic stimulus that precedes the startling stimulus by roughly 10–1000 ms (prepulse inhibition, PPI). At long interstimulus intervals (ISIs) of 100–1000 ms, PPI in rats is reduced by the muscarinic receptor antagonist scopolamine. Here, we studied the role of GABA receptors in PPI at full ISI ranges in both mice and rats. In B6 mice, PPI begins and ends at shorter ISIs (4 and 1000 ms, respectively) than in Wistar rats (8 and 5000 ms). The GABAA antagonist bicuculline (1 mg/kg i.p.) reduced PPI at ISIs near the peak of PPI in both rats and mice. The GABAB antagonist phaclofen (10 or 30 mg/kg i.p. in rats or mice, respectively) reduced PPI only at long ISIs, similar to the effects of the muscarinic antagonist scopolamine (1 mg/kg i.p.). The effects of phaclofen and scopolamine were additive in rats, suggesting independent effects of GABAB and muscarinic receptors. Patch‐clamp recordings of startle‐mediating PnC (nucleus reticularis pontis caudalis) giant neurons in rat slices show that EPSCs evoked by either trigeminal or auditory fiber stimulation were inhibited by the GABAA/C agonist muscimol or the GABAB agonist baclofen via postsynaptic mechanisms. Hyperpolarization of PnC neurons by muscimol was reversed with bicuculline, indicating that postsynaptic GABAA receptors strongly inhibit PnC giant neurons needed for startle. Therefore, GABA receptors on PnC giant neurons mediate a substantial part of PPI, with GABAA receptors contributing at the peak of PPI, and GABAB receptors adding to muscarinic effects on PPI at long ISIs.
The Use of Mind Mapping on Economic Learning at SMK Negeri 1 Malang

Abstract The purpose of this research is to find out how mind mapping learning method can improve learning activeness in class. This research was conducted in SMK Negeri 1 Malang on Business Economics subjects material scarcity and sub theme of requirement. The sample in this research is students of class X AP 1 as many as 40 students. In the sample, the selection is not based on tribe, religion, race, and learning outcomes. In implementing the teaching, teachers apply 3 stages in accordance with the lesson plan that is the beginning, core, and closing activities. The application of mind mapping learning method is applied to the core stages of learning. The result of this research is student activeness in learning using mind mapping method looks increasing. Students are active and no students are found that are not active in learning. Keywords : Mind Mapping, Economic Learning, Classroom Research DOI: 10.17977/um013v1i12017p012