Miracle-dz/UniFAR-FTUs huggingface dataset:
Pulmonary , gastrointestinal and urogenital pharmacology The vitamin D receptor agonist , calcipotriol , modulates fi brogenic pathways mitigating liver fi brosis in-vivo : An experimental study

Vitamin D was found to be involved in liver fibrosis modulation through binding to its receptor (VDR) halting many fibrotic pathways. Targeting vitamin D-VDR axis using vitamin D analogs may represent an efficient strategy for liver fibrosis treatment . The study aims at testing the potential ability of the VDR agonist, calcipotriol, to stop fibrosis progression and/or regeneration of hepatocytes in an experimental model of liver fibrosis. Mice (CD-1) were injected with thioacetamide (TAA, 100 mg/kg, i.p., 3 times/ week) for 8 weeks to induce fibrosis and were treated with calcipotriol (20, 60 or 80 mg/kg, i.p., daily) concurrently with TAA during the last 4 weeks. Liver function and oxidative stress biomarkers were measured by the end of the study and hepatic sections were examined for inflammation, necrosis and fibrosis percentage. Additionally, liver contents of collagen-1-alpha-1 (COL1a1), transforming growth factor (TGF)-β1 and phospho-Smad2 (Ser456/467)/Smad3 (Ser423/425) were measured. Finally, expression of TGF-β1, tissue inhibitor metalloproteinase (TIMP)-1, Smad2/3 and Smad1/5/9 were scored using immunohistochemistry techniques. Mainly, calcipotriol (80 mg/kg) significantly (Po0.001) reduced fibrosis percentage and improved TAA effect on transaminases, alkaline phosphatase, COL1a1 level, malondialdehyde, albumin and reduced glutathione (GSH). It also decreased the profibrogenic cytokine TGF-β1, TIMP-1, Smad2/3, Smad1/5/9 and phospoSmad2/3 significantly (Po0.01) when compared to TAA group. Calcipotriol attenuates TAA induced liver fibrosis and can stop its progression through limiting stellate cells activity by decreasing TGF-β1 level and modulating TGF-β1/Smad signaling pathway. It also can help fibrolysis through decreasing TIMP-1 and restoring the balance between metalloproteinases and their inhibitors. & 2016 Elsevier B.V. All rights reserved.
THE PRESENT AND FUTURE STATE-OFTHE -

Ma Vitamin D deficiency is typically caused by inadequate cutaneous synthesis secondary to decreased exposure to sunlight. Serum levels of 25-hydroxyvitamin D l <20 ng/ml are diagnostic of vitamin D deficiency. Vitamin D has various cardiovascular pleiotropic effects by activating its nuclear receptor in cardiomyocytes and vascular endothelial cells and by regulating the renin-angiotensin-aldosterone system, adiposity, energy expenditure, and pancreatic cell activity. In humans, vitamin D deficiency is associated with the following: vascular dysfunction; arterial stiffening; left ventricular hypertrophy; and worsened metrics of diabetes, hypertension, and hyperlipidemia. It is also linked with worse cardiovascular morbidity and mortality. However, meta-analyses of vitamin D supplementation trials have failed to show clear improvements in blood pressure, insulin sensitivity, or lipid parameters, thus suggesting that the link between vitamin D deficiency and cardiovascular disease may be an epiphenomenon. Ongoing larger randomized trials will clarify whether monitoring and supplementation of vitamin D play roles in cardiovascular protection. (J Am Coll Cardiol 2017;70:89–100) © 2017 by the American College of Cardiology Foundation.
Melodic pattern test of temporal processing : an analysis of different types of responses

Purpose: Evaluate the results of the different forms of responses in the melodic temporal ordering test in relation to frequency and duration. Methods: The sample was composed of 33 subjects, for convenience, aged between 17 and 27 years old, normal hearing individuals, presenting no complaints regarding auditory processing and having no hearing impairment, syndromes or craniofacial malformation history; no physical disability (manual), as well as no neurological and speech impairment and education level greater than nine years. They were subjected to the temporal ordering test with musical tone, called melodic Duration Pattern Test (DPT) and Frequency Pattern Test (FPT), applied under three response conditions (motor, humming and motor), performed on the same date. For that, at a first moment, the induvial were asked to recognize the stimuli verbally, then characterize the stimuli in an imitative pattern and, finally, to recognize the stimuli in manual responses. Results: Statistically significant differences were not observed between the three forms of responses for DPT and FPT. However, it is remarkable that there was a greater number of changes for FPT than for DPT, regardless the form of response. Furthermore, motor and verbal responses presented more changes for humming, in FPT. Conclusion: The different forms of response (motor, humming and motor) for the melodic DPT and FPT did not change the results.
Combination , for Hip Osteoarthritis : A Randomized Controlled Study Ultrasound-Guided Injection of Platelet-Rich Plasma and Hyaluronic Acid , Separately and in

http://ajs.sagepub. com/content/44/3/664 The online version of this article can be found at: DOI: 10.1177/0363546515620383 2016 44: 664 originally published online January 21, 2016 Am J Sports Med Gianluca Giavaresi Dante Dallari, Cesare Stagni, Nicola Rani, Giacomo Sabbioni, Patrizia Pelotti, Paola Torricelli, Matilde Tschon and Combination, for Hip Osteoarthritis: A Randomized Controlled Study Ultrasound-Guided Injection of Platelet-Rich Plasma and Hyaluronic Acid, Separately and in
Methods of Analysis of Lisinopril: A Review

Lisinopril is an (ACE) angiotensin-converting enzyme inhibitor and is used in the treatment of high blood pressure, heart failure, and heart attacks. Numerous analytical methods have been developed for the determination of lisinopril. These methods include Chromatographic methods, UV spectrophotometric methods, IR, Polarographic, Stress degradation, titration and assay. This review outlines the applications of these techniques for the determination of lisinopril in pharmaceutical preparations.
Seismic hazard analysis using simulated ground-motion time histories : The case of the Se fi drud dam , Iran

This study aims at conducting probabilistic seismic hazard analysis for the Sefidrud dam located near Rudbar City. For this purpose, firstly, the characteristic earthquake recurrence model for major earthquakes on individual main faults have been combined with the smaller (smoothed) background seismicity of the region. Then, appropriate ground motion prediction equations were applied to estimate hazard values. Finally, in order to obtain reliable estimation of seismic hazard due to sources close to the dam site and to investigate near-field characteristics of motion, the Rudbar fault as the most prominent earthquake source in the immediate vicinity of the site is considered in seismic hazard computation using hybrid broadband simulation based ground motion parameters. The results of this method with different declustering schemes are reported for two level of seismic hazard analysis (i.e. return periods of 475 and 2475 years). Best estimate seismic hazard maps of PGA and PGV values obtained from the logic tree method is presented. By inclusion of simulation results for the Rudbar fault in the probabilistic seismic hazard analysis (PSHA), maximum PGA and PGV for 475 years return period obtained around 340 cm/s/s and 25 cm/s, respectively. For classic PSHA without including simulation the maximum PGA and PGV for 475 years return period obtained around 450 cm/s/s and 32 cm/s, respectively. With the simulation-based PSHA for a 2475 years return period a maximum PGA of 650 cm/s/s and PGV of 50 cm/s have been estimated. Classic PSHA (without simulation) for a 2475 years return period has resulted a maximum PGA of 850 cm/s/s and PGV of 65 cm/s.
Suzaku Detection of Thermal X-Ray Emission Associated with the Western Radio Lobe of Fornax A

We present the results of X-ray mapping observations of the western radio lobe of the Fornax A galaxy, using the X-ray Imaging Spectrometer (XIS) onboard the Suzaku satellite with a total exposure time of 327 ks. The purpose of this study is to investigate the nature and spatial extent of the diffuse thermal emission around the lobe by exploiting the low and stable background of the XIS. The diffuse thermal emission had been consistently reported in all previous studies of this region, but its physical nature and relation to the radio lobe had not been examined in detail. Using the data set covering the entire western lobe and the central galaxy NGC 1316, as well as comparison sets in the vicinity, we find convincingly the presence of thermal plasma emission with a temperature of ~1 keV in excess of conceivable background and contaminating emission (cosmic X-ray background, Galactic halo, intra-cluster gas of Fornax, interstellar gas of NGC 1316, and the ensemble of point-like sources). Its surface brightness is consistent with having a spherical distribution peaking at the center of the western lobe with a projected radius of ~12 arcmin. If the volume filling factor of the thermal gas is assumed to be unity, its estimated total mass amounts to ~10^{10} M_sun, which would be ~10^{2} times that of the central black hole and comparable to that of the current gas mass of the host galaxy. Its energy density is comparable to or larger than those in the magnetic field and non-thermal electrons responsible for the observed radio and X-ray emission.
Physicochemical and Pharmacokinetic Characteristics of Iodinated Contrast Physicochemical Properties of Contrast Media Iodinated

Iodinated contrast media are among the most commonly used pharmacologic agents in medicine. Although generally highly safe, iodinated contrast media are associated with several adverse effects, most significantly the risk of acute kidney injury, particularly in patients with underlying renal dysfunction. By virtue of their pharmacokinetic characteristics, these contrast agents are efficiently cleared by hemodialysis and to a lesser extent, hemofiltration. This has led to research into the capacity for renal replacement therapies to prevent certain adverse effects of iodinated contrast. This review examines the molecular and pharmacokinetic characteristics of iodinated contrast media and critically analyzes data from past studies on the role of renal replacement therapy to prevent adverse effects of these diagnostic agents. Published by Elsevier Inc. on behalf of the National Kidney Foundation, Inc.
Thai Learners' English Pronunciation Competence: Lesson Learned from Word Stress

English has been a lingua franca in various domains of communication such as international business, academic conferences, diplomacy, science and technology. As a result, the demands for English skills in all aspects are crucial in response to the importance of English and the impact of globalization. Despite the constant efforts in developing English education in Thailand, a number of studies have shown that the achievement of Thai learners was unsatisfactory. Given the role of English as an international language which is used in almost domain of communication, amongst several factors hindering the success of English language learning, English pronunciation of the Thai learners should be focused. This study has two principle objectives: 1) to examine Thai learners' knowledge with regard to word stress assignment; and 2) to determine possible factors affecting the Thai learners' pronunciation competence. To achieve these objectives, 90 Thai learners of English participated in this study. The test consisting of two parts: personal information profile, and 40 selected words systematically taken from two textbooks, was employed to identify these participants' pronunciation competence. The results showed that most of the participants' English pronunciation was somewhat limited. Gender was identified to be the most significant factor contributing to the participants' test scores, while faculty and years of studying English were not. In light of the results suggested by the three variables, pedagogical suggestions were offered to help improve teaching and learning English pronunciation in general, and in focusing on the importance of teaching word stress in particular.
Growth Performances and Carcass Characteristics of Broiler Chickens Fed Akasya [Samanea Saman (Jacq.) Merr.] Pod Meal

Akasya pods are seasonally abundant and are good sources of protein and energy and have been considered as an alternative feed source for livestock. This study was conducted to determine the effects of feeding Akasya pod meal (APM) on the growth performances and carcass characteristics of broiler chickens. Three hundred straight-run 7-day-old Cobb broiler chicks were randomly allocated to five dietary treatments containing 0%, 0.5%, 1.0%, 2.5%, and 5.0% APM following a completely randomized design. Each treatment was replicated 10 times with 10 birds per replicate. The digestibility of nutrients was also evaluated to determine the effect of different levels of APM on the efficiency of nutrient digestion in broilers. Broilers fed APM level at more than 1.0% had lower body weights and body weight gains, but feed intake, feed conversion ratio, livability, and carcass characteristics were not affected by increasing levels of APM. The digestibility of crude protein (CP), crude fiber (CF), nitrogen free extract (NFE), ether extract (EE), and energy were the same in broilers across treatments. Increased income over chick and feed cost (IOFCC) was generated from broilers fed diets with 0.5% APM, but progressively declined as APM level in the diet was increased. In conclusion, APM can be used in broiler diets at inclusion levels up to 1.0% wherein growth performance and carcass characteristics were optimum in broilers and income generated was improved at 0.5% level.
Fluctuations of Raikot Glacier during the past 70 years: a case study from the Nanga Parbat massif, northern Pakistan

The Himalaya has some of the largest glacier concentrations outside the polar regions. Despite this, long-term measurements detecting the impact of global warming and changing precipitation patterns on glaciers are rare. The Nanga Parbat massif in northern Pakistan is an exception. The cartographer and glaciologist R. Finsterwalder investigated glacier dynamics of this mountain massif in the 1930s, and several other studies document changes since then. The aim of this study is to detect and analyse the changes of Raikot Glacier over the past seven decades. We use a multitemporal and multiscale approach, based on repeat terrestrial images, additional historical data and remotely sensed imagery (Corona, ASTER, Landsat, QuickBird). The multitemporal approach covers the period 1934-2007. While the analyses show a total glacier retreat of � 200 m in 73 years, this general trend was interrupted by a significant glacier advance between the 1950s and 1980s. Although down-wasting processes can be inferred from an increase in debris-covered area, a general trend of reduced glacier thickness does not appear significant over the whole observation period.
Effects of a Bacillus thuringiensis toxin, two Bacillus thuringiensis biopesticide formulations, and a soybean trypsin inhibitor on honey bee (Apis mellifera L.) survival and food consumption

Des abeilles fraichement ecloses ont ete encagees (40/cage) et ont recu un sirop de sucre (60 % masse/volume) et de l'eau ad libitum et une nourriture a base de pollen et de divers additifs. Les additifs utilises etaient les suivants : la δ-endotoxine Cry1Ba purifiee et activee, venant de Bacillus thuringiensis Bt4412 (Bt) (1, 0,25 et 0,025 % masse/masse), deux preparations biopesticides de Bt: Dipel 2X (1 et 0,25 %) et Foray 48B (0,25 %) et l'inhibiteur de trypsine soja de Kunitz (SBTI) (1, 0,5 ou 0,05 %). Les concentrations de CrylBa et de SBTI ont ete choisies de facon a correspondre a trois niveaux d'expression dans les plantes transgeniques: un niveau eleve non realiste et deux concentrations que l'on peut s'attendre a trouver dans les plantes exprimant ces proteines a des niveaux efficaces contre les insectes depredateurs. Les concentrations en CrylBa equivalent a des niveaux d'expression dans la plante de 4, 1, et 0,1 % de la proteine totale et celles de SBTI a 4, 2 et 0,2 % de la proteine totale. Le traitement au Dipel a 1 % equivaut a 4 % de la proteine totale et se situe bien au-dessus des niveaux de pulverisation recommandes pour ce biopesticide. Les traitements au Dipel et au Foray a 0,25 % equivalent a 1 % de la proteine totale et s'approchent de la DL 50 pour un pesticide qui est « virtuellement non toxique » pour les abeilles. Trois blocs de neuf traitements et un temoin ont ete mis en place (30 cages au total). Les abeilles ont ete maintenues en etuve a 32 °C. Elles ont recu les aliments durant sept jours, puis la nourriture temoin sans additifs pendant le reste de leur vie. La mortalite des abeilles dans les cages a ete verifiee et les recipients de nourriture a base de pollen ont ete peses toutes les 12 h durant cinq jours, puis chaque jour durant les quatre jours suivant et trois fois par semaine jusqu'a ce que les abeilles meurent. La survie des abeilles n'a pas ete affectee par les traitements et la nourriture avec additif a ete consommee au meme rythme que la nourriture temoin pour tous les traitements, sauf celui au Dipel a 1 % (figures 1b et 2b). Une seconde experience a montre que les abeilles totalement privees de nourriture a base de pollen survivaient moins longtemps que celles ayant recu la nourriture temoin (figure 1d). Nous concluons qu'il est peu probable que les plantes transgeniques exprimant CrylBa, SBTI ou les biopesticides utilises aux doses recommandees presentent une toxicite directe pour les abeilles adultes. Neanmoins il serait souhaitable de proceder a d'autres etudes sur des abeilles en conditions naturelles et d'examiner les effets sub-letaux.
Chemosensitivity as a Predictive Biological Marker in Lymphoma

In the present article, the authors reviewed the rationale of FDG-PET/CT performed at an interim time point during therapy (iPET), focusing on the transition from standard, anatomical assessment of tumor shrinkage with CT to document a chemotherapy response, to the use of functional imaging with PET to assess chemosensitivity of the individual tumor. The prognostic or predictive role of iPET in different lymphoma subsets has been reviewed, with particular emphasis on early and advanced-stage Hodgkin lymphoma, diffuse large B-cell lymphoma, peripheral T-cell lymphoma, extranodal natural killer/T-cell lymphoma, and primary mediastinal B-cell lymphoma. A large body of evidence exists in most lymphoma subtypes stressing the role of iPET for early chemotherapy response during first-line chemotherapy treatment, but an increased number of reports have recently been published focusing on the role of iPET in relapsed or refractory lymphoma to predict treatment outcome. Varying patterns of FDG uptake was observed across various lymphoma entities; hence, interpretation of FDG-PET scans should be in the context of the tumor architecture and the prevalence of cellular population, in particular, neoplastic vs non-neoplastic inflammatory cells present in tissue microenvironment. In the second part of the article, the authors reviewed the iPET–response adapted clinical trials and the clinical benefits of this strategy compared to standard non–PET adapted therapy. In particular, the authors extrapolated the reproducibility of FDG-PET image interpretation and the feasibility of a timely treatment adaptation based on FDGPET results in daily clinical practice. This is essential for the reader, as the iPET-adapted strategy has become the standard of care in both earlyand advanced-stage Hodgkin lymphoma, and, in the future, probably this strategy will be expanded to primary mediastinal B-cell lymphoma, follicular lymphoma, and peripheral T-cell lymphoma. Semin Nucl Med ■■:■■–■■ © 2017 Elsevier Inc. All rights reserved.
Modelling and labelling behaviours Q 3 . rstb . royalsocietypublishing

As the publishing schedule is strict, please note that this might be the only stage at which you are able to thoroughly review your paper. Please pay special attention to author names, affiliations and contact details, and figures, tables and their captions. If you or your co-authors have an ORCID ID please supply this with your corrections. More information about ORCID can be found at http://orcid.org/. No changes can be made after publication.
Seeding experiments at SPARC

In the framework of the DS4 EUROFEL collaboration, a research work plan at the SPARC free-electron laser (FEL) test facility aiming at the investigation of seeded and cascaded FEL configurations is under implementation. The main goal of the collaboration is to study and test the amplification and the FEL harmonic generation process of an input seed signal obtained as higher-order harmonics generated both in crystals (400 and 266 nm) and in gases (266, 160, 114 nm). The SPARC FEL can be configured to test several cascaded FEL configurations. In this paper we introduce SPARC and its main parameters and we analyze the superradiant cascade and the harmonic cascade seeded with a signal with the typical time structure of the harmonics generated in gas. & 2008 Elsevier B.V. All rights reserved.
Processing Confers a Novel Function in RNA Receptor β Transforming Growth Factor Nuclear Translocation of Type

Published Ahead of Print 2 April 2012. 10.1128/MCB.00320-12. 2012, 32(12):2183. DOI: Mol. Cell. Biol. Ren-Jang Lin and Shizhen Emily Wang Chow, Weiying Zhou, Yang Yu, Harry Gao, Xiubao Ren, Zimmerman, Jackson Champer, Akihiro Tsuyada, Amy Manasa Chandra, Shengbing Zang, Haiqing Li, Lisa J. Processing Confers a Novel Function in RNA Receptor β Transforming Growth Factor Nuclear Translocation of Type I
HACD 1 in Maintaining Skeletal Muscle Membrane Systems

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 ajp.amjpathol. org 63 64 65 66 67 68 69 70 71 72 73 74 75 76 Progressive Structural Defects in Canine Centronuclear Myopathy Indicate a Role for 77 78 79 80 81 82 HACD1 in Maintaining Skeletal Muscle Membrane Systems Gemma L. Walmsley,* Stéphane Blot,yz Kerrie Venner,x Caroline Sewry,{ Jocelyn Laporte,k Jordan Blondelle,yz Inès Barthélémy,yz Marie Maurer,yz Nicolas Blanchard-Gutton,yz Fanny Pilot-Storck,yz Laurent Tiret,yz and Richard J. Piercy*