Miracle-dz/UniFAR-FTUs huggingface dataset:
Reactive Powder Concrete Mix Ratio and Steel Fiber Content Optimization under Different Curing Conditions

In this paper, a practical reactive powder concrete mixture ratio is created on the basis of an orthogonal experiment. Previous studies have combined the compressive and splitting tensile strengths of four categories of reactive powder concrete (RPC) for major materials. These categories include water/binder ratio, silica fume volume content, sand/binder ratio, and dosage of fly ash volume. The optimal mixing proportion of each factor was determined by analyzing the compressive strength of the RPC matrix. For this purpose, steel fiber was used as a reinforcing agent. The compressive and splitting tensile strength test results of steel fiber RPC were analyzed by comparing compound, standard, and natural curing. This was conducted to explore the improvement effect of different steel fiber contents on compressive performance, especially tensile strength of the RPC matrix. According to the results, the optimal steel fiber content was found to be 4% under the three curing conditions. The effect of compound curing on early strength was found to be greater in RPC than by natural or standard curing. However, the effect of late improvement is not obvious. Although standard curing is slightly stronger than natural curing, the performance under the latter can still meet engineering requirements.
The Influence of Relationship Quality on the Participation of Secondary Respondents: Results from the German Family Panel

Die pairfam-Studie bietet die seltene Moglichkeit, dyadische Analysen von Partner- sowie Eltern-Kind-Beziehungen durchzufuhren. Es werden im Rahmen der Studie namlich nicht nur die zufallig gezogenen Ankerpersonen befragt, sondern – mit Zustimmung der Ankerpersonen – auch deren Partner, Eltern und Kinder. Allerdings stellt sich die Frage, ob bzw. inwieweit die Teilnahme der sekundaren Respondenten selektiv ist, also die dyadischen Daten durch einen Nonresponse-Bias verzerrt sind. Dieser Beitrag analysiert, welche Faktoren die Teilnahme der Partner und Eltern der Ankerperson am Beziehungs- und Familienpanel pairfam beeinflussen. Im Mittelpunkt steht dabei die Frage, ob die Qualitat der Beziehung zwischen Anker und Partner bzw. Anker und Elternteil einen Einfluss auf die Teilnahme hat. Bei den Eltern zeigt sich sowohl ein Einfluss der Beziehungsqualitat im engeren Sinne als auch ein Einfluss der Dichte der Beziehung im Hinblick auf Kontakt und gegenseitige Unterstutzung. Fur die Teilnahme der Partner scheint die Beziehungsqualitat hingegen eine geringere Bedeutung zu haben, einen grosen Einfluss hat aber der Institutionalisierungsgrad der Beziehung. Der Beitrag mochte pairfam-Nutzer fur die Moglichkeit eines Nonresponse-Bias bei dyadischen Analysen sensibilisieren und gibt Hinweise zum angemessenen Umgang mit den Daten.
Effect of Different Concentrations of Cobalt on Pigment Contents of Soybean

A pot culture experiment was conducted to estimate the effect of cobalt (0, 50, 100, 150, 200 and 250 mg kg soil) on pigment accumulation of soybean. Pot culture experiments were conducted. Periodical 1 observations were made to record. From the results, it is observed that, cobalt at lower concentrations have some beneficial values on soybean.
Effect of sowing time and plant density on the growth and production of roselle (Hibiscus sabdariffa).

Experiments were conducted to see the response of roselle to different sowing dates and plant spacing. Six different sowing dates (seed sown at 10 days intervals on 6 May, 16 May, 26 May, 5 June, 15 June and 25 June) were used as main plots and six different planting densities (2, 3, 5, 7, 11 and 18 plants m) as sub plots. Results showed that plant height, stem diameter, number of leaves, number of calyces per plant, fresh weight of calyces per plant, dry weight of calyces per plant and calyces yield per ha was significantly affected by different sowing dates as well as planting densities. Maximum plant height (175 cm), stem diameter (3.1 cm), number of leaves per plant (636), number of calyces per plant (104), calyces fresh (206 g) and dry (21.7 g) weight plant, and calyces yield per ha (1427 kg) was recorded for the plants sown on 6 May, while these traits decreased with delayed sowing. For plant densities, the tallest plants (155 cm) with maximum calyces yield per ha (2496 kg) were observed at the highest density of 18 plants m, though the per plant stem diameter (2.9 cm), number of leaves (653), number of calyces (99), calyces fresh (205 g) and dry (24.9 g) weight were higher at the lowest density of 2 plants m. It was concluded that 6 May sowing and 18 plants m planting density produced the highest yield per ha in roselle crop. © 2016 Friends Science Publishers
NR2F1‐AS1 regulated miR‐423‐5p/SOX12 to promote proliferation and invasion of papillary thyroid carcinoma

Papillary thyroid carcinoma (PTC) is an aggressive histological subtype of thyroid carcinoma (THCA), whose occurrence rate is high. The participation of long noncoding RNAs in the pathologies of cancers has attracted significant attention during the past decades. The purpose of the current study is to investigate the role of NR2F1 antisense RNA 1 (NR2F1‐AS1) in PTC. The expression of NR2F1 in THCA samples was analyzed by bioinformatics tool gene expression profiling interactive analysis. Levels of NR2F1‐AS1, microRNA‐423‐5p (miR‐423‐5p), and SRY‐box 12 (SOX12) were evaluated by a quantitative reverse transcription‐polymerase chain reaction and Western blot. The impact of NR2F1‐AS1 on PTC cell proliferation and invasion was assessed by Cell Counting Kit‐8, EdU, and Transwell invasion assays. The interactions among NR2F1‐AS1, miR‐423‐5p, and SOX12 were determined by RNA immunoprecipitation and luciferase reporter assays. Consequently, we found that NR2F1‐AS1 and SOX12 levels were elevated in PTC, whereas miR‐423‐5p was downregulated in PTC cells. Functionally, NR2F1‐AS1 silence led to reduced proliferation and invasion of PTC cells. Mechanistically, NR2F1‐AS1 interacted with miR‐423‐5p to induce SOX12 expression in PTC cells. In conclusion, the present study firstly stated that NR2F1‐AS1 regulated miR‐423‐5p/SOX12 to promote proliferation and invasion of PTC, indicating NR2F1‐AS1 as a potential novel target for the molecular‐targeted therapy of PTC.
Lactate Efflux From Intervertebral Disc Cells Is Required for Maintenance of Spine Health

Maintenance of glycolytic metabolism is postulated to be required for health of the spinal column. In the hypoxic tissues of the intervertebral disc and glycolytic cells of vertebral bone, glucose is metabolized into pyruvate for ATP generation and reduced to lactate to sustain redox balance. The rise in intracellular H+/lactate concentrations are balanced by plasma‐membrane monocarboxylate transporters (MCTs). Using MCT4 null mice and human tissue samples, complemented with genetic and metabolic approaches, we determine that H+/lactate efflux is critical for maintenance of disc and vertebral bone health. Mechanistically, MCT4 maintains glycolytic and tricarboxylic acid (TCA) cycle flux and intracellular pH homeostasis in the nucleus pulposus compartment of the disc, where hypoxia‐inducible factor 1α (HIF‐1α) directly activates an intronic enhancer in SLC16A3. Ultimately, our results provide support for research into lactate as a diagnostic biomarker for chronic, painful, disc degeneration. © 2019 American Society for Bone and Mineral Research.
Phase III randomized trial of bisphosphonates as adjuvant therapy in breast cancer: S0307.

BACKGROUND Adjuvant bisphosphonates, when given in a low estrogen environment, can decrease breast cancer recurrence and death. Treatment guidelines include recommendations for adjuvant bisphosphonates in postmenopausal patients. SWOG/Alliance/Canadian Cancer Trials Group/ECOG-ACRIN/NRG Oncology study S0307 compared the efficacy of three bisphosphonates in early stage breast cancer. METHODS Patients with stage I-III breast cancer were randomized to 3 years of intravenous zoledronic acid, oral clodronate, or oral ibandronate. The primary endpoint was disease-free survival (DFS) with overall survival (OS) a secondary outcome. All statistical tests were two-sided. RESULTS 6,097 patients enrolled. Median age was 52.7 years. Prior to randomization, 73.2% of patients indicated preference for oral versus intravenous formulation. DFS did not differ across arms in a log-rank test (p = 0.49). 5-year DFS was 88.3% (zoledronic acid, 95% CI 86.9%-89.6%), 87.6% (clodronate, 95% CI 86.1%-88.9%), and 87.4% (ibandronate, 95% CI 85.6%-88.9%). 5-year OS also did not differ between arms (log rank p = 0.50) and was 92.6% (zoledronic acid, 95% CI 91.4%-93.6%), 92.4% (clodronate 95% CI 91.2%-93.5%), and 92.9%% (ibandronate 95% CI 91.5%-94.1%). Bone as first site of recurrence did not differ between arms (P = 0.93). Analyses based on age and tumor subtypes showed no treatment differences. Grade 3/4 toxicity was 8.8% (zoledronic acid), 8.3% (clodronate), and 10.5% (ibandronate). Osteonecrosis of the Jaw (ONJ) was highest for zoledronic acid (1.26%), compared to clodronate (0.36%) and ibandronate (0.77%). CONCLUSIONS We found no evidence of differences in efficacy by type of bisphosphonate, either in overall analysis or subgroups. Despite an increased rate of ONJ with zoledronic acid, overall toxicity grade differed little across arms. Given that patients expressed preference for oral formulation, efforts to make oral agents available in the U.S. should be considered.
Happiness and Life Satisfaction in Advanced European Countries

Based on the European Value Survey 1999, this article analyzes happiness and life satisfaction in nine rich, industrialized countries with different levels of perceived happiness. Using graphical modeling, the statistical analysis showed that happiness and life satisfaction are related but are different concepts and that contextual as well as individual variables are important in explaining their variations. One of the most important results is that happiness depends on whether the respondent lives in a stable relationship and on country characteristics. Life satisfaction was related to the respondent’s feeling of control and his or her country of residence. In an aggregated analysis, the country-specific variables were analyzed, showing that social capital was the most important predictor of happiness.
Effects of Different Plant Density and Cutting Times on Yield of Stevia under the Çukurova Conditions

Stevia ( Stevia rebaudiana Bertoni) is perennial shrub form plant belonging to Asteraceae. It is indigenous to Paraguay and Brazil. Stevia is a natural sweetening and it has using potential to diets of obesity patients with non-caloric specialty and treatment of diabetes with insulin secretagogue specialty. In this study, the effects of different planting spaces and two cutting times on yields of two-year old Stevia plant were investigated. The highest dry leaf yield (515.96 kg/da) was obtained from blooming stage, cuttings in spring and 30x60 cm planting density.
Greek Adaptation of the Positive Aspects of Caregiving (PAC) Scale in Dementia Caregivers

ABSTRACT Objectives: The aim of the present study is to validate the Positive Aspects of Caregiving (PAC) scale in Greek informal family caregivers of patients with dementia, in order to assess its psychometric properties. Methods: Two hundred and forty-seven dementia caregivers completed the Greek version of the PAC (G-PAC) scale in correlation with the following psychometric tools, the Beck Depression Scale, the Zarit Burden Interview (ZBI), the Beck Anxiety Inventory (BAI), the Quality of Life-AD (QoL-AD), the Perceived Stress Scale (PSS), and the Neuropsychiatric Inventory (NPI). Caregivers were included in the study after they had been initially informed of its purpose and completed the informed consent. Results: The Principal Component Analysis (PCA) extracted two factors for the G-PAC, which is also in agreement with the original version, which is Enriching Life and Affirming Self. Concurrent validity suggested significant correlations between G-PAC and behavioral and psychological symptoms of dementia and with perceived stress. In regard to the reliability measures, the results showed that the G-PAC scale has very good internal reliability and high levels of test–retest reliability. Conclusions: The scale is a both valid and reliable tool, and therefore it can be used to assess the positive aspects of caregiving in dementia caregivers. Clinical implications: The development of positive psychology measures in dementia care can be regarded as the cornerstone of the psychotherapeutic interventions addressed to caregivers, and therefore helping them to adapt better in their caregiving role.
Phytochrome B Induces Intron Retention and Translational Inhibition of PHYTOCHROME-INTERACTING FACTOR31[OPEN]

Light down-regulates photomorphogenic repressor PHYTOCHROME-INTERACTING FACTOR3 by multiple mechanisms, including phytochrome B-induced alternative splicing that inhibits PIF3 protein translation. The phytochrome B (phyB) photoreceptor stimulates light responses in plants in part by inactivating repressors of light responses, such as PHYTOCHROME-INTERACTING FACTOR3 (PIF3). Activated phyB inhibits PIF3 by rapid protein degradation and decreased transcription. PIF3 protein degradation is mediated by EIN3-BINDING F-BOX PROTEIN (EBF) and LIGHT-RESPONSE BTB (LRB) E3 ligases, the latter of which simultaneously targets phyB for degradation. In this study, we show that PIF3 levels are additionally regulated by alternative splicing and protein translation in Arabidopsis (Arabidopsis thaliana). Overaccumulation of photo-activated phyB, which occurs in the mutant defective for LRB genes under continuous red light, induces a specific alternative splicing of PIF3 that results in retention of an intron in the 5′ untranslated region of PIF3 mRNA. In turn, the upstream open reading frames contained within this intron inhibit PIF3 protein synthesis. The phyB-dependent alternative splicing of PIF3 is diurnally regulated under the short-day light cycle. We hypothesize that this reversible regulatory mechanism may be utilized to fine tune the level of PIF3 protein in light-grown plants and may contribute to the oscillation of PIF3 protein abundance under the short-day environment.
Effects of magnetic fields pretreatment of mungbean seeds on sprout yield and quality

The aim of this investigation was to determine the effect of magnetic field pretreatment of mungbean seeds on the yield and quality of sprout. The sprout elongation, biomass and nutrition ingredients (for example, concentration of soluble sugar, protein, vitamin C, etc.) were measured to test this effect of magnetic field. The results show that magnetic field stimulation caused 25, 9 and 5.4% increment in sprout elongation, fresh weight and dry weight compared with the control. Similarly, compared to the control, magnetic field pretreatment caused an increase by 12% in the concentration of spouts protein, by 5.1% in the concentration of spouts soluble sugar, by 13.8% in the concentration of spouts vitamin C, and by 113% in the concentration of anthocyanin concentration. Similarly, the concentration of arginine (Arg), histidine (His), lysine (Lys), phenylalanine (Phe), tyrosine (Tyr), leucine (Leu), isoleucine (ILe), glutamic acid (Glu), serine (Ser) and threonine (Thr) were also significantly increased by 600 mT magnetic field pretreatment. Therefore, the results suggest that 600 mT magnetic field can enhance the yield and quality of mungbean sprouts and can be applied to sprouts produce. Keywords: Magnetic field, mungbean sprout, sprout quality, nutrition components, vitamin C
IL-37 Plays a Beneficial Role in Patients with Acute Coronary Syndrome

Background Interleukin-37 (IL-37) acts as an inhibitor of innate and adaptive immunity. However, the exact role of IL-37 in the patients with acute coronary syndrome (ACS) remains to be elucidated. Methods Patients were classified into 4 groups: normal coronary artery (NCA), stable angina (SA), unstable angina (UA), and acute myocardial infarction (AMI). The circulating Treg, Th1, and Th17 frequencies were measured. The effect of IL-37 on stimulated peripheral blood mononuclear cells (PBMCs) and the influence of IL-37 on DCs were explored. In addition, the role of IL-37-treated tDCs on Treg cell expansion and the stability of these tDCs were also tested. Results Our results showed that the circulating Treg frequencies were decreased, while Th1 and Th17 frequencies were increased in ACS patients, and that IL-37 expanded Tregs but suppressed Th1 and Th17 cells in activated PBMCs derived from ACS patients. Of note, IL-37-treated human DCs obtained a tolerogenic phenotype, and such tDCs promoted expansion of Tregs and decreased the Th1 and Th17 populations when cocultured with CD4+ T cells. Interestingly, IL-37-treated DCs from patients with ACS are phenotypically and functionally comparable to IL-37-treated DCs from NCA patients, and tolerogenic properties of IL-37-treated DCs were highly stable. Conclusion In conclusion, our results reveal a beneficial role of IL-37 in the patients with ACS and suggest that autologous IL-37-treated tDCs may be a novel therapeutic strategy for the patients with ACS.
Switching to a Temporary Call Auction in Times of High Uncertainty

We evaluate a stock specific circuit breaker mechanism implemented in several European stock exchanges, which consists of a short-lived call auction triggered by intraday stock-specific price limits. This switching mechanism differs from the previously studied US trading halts in that it is short-lived, non-discretionary, and there is always a trading mechanism (continuous or discrete) going. It differs from daily price limits in that trade prices are not restricted once the limit has been hit; moreover, the intraday price ranges are smaller and adjusted to the recent volatility of the stock, so that limit hits are more frequent. Using data from the Spanish Stock Exchange (SSE), we show that market conditions remain usually high no longer than 90 minutes after the resumption of the continuous session. Adverse selection costs are unusually high near the time of the limit hit, but they revert to normal levels in no longer than 30 minutes after the restart of continuous trading phase. Moreover, price patterns show continuations during the 5-minute auction period and strong reversals in the 30-minute interval following the resumption of the continuous session. Afterwards, prices stabilize. These price patterns suggest that limit hits in the SSE are mostly provoked by noise traders overreacting to new information. We also show that higher returns during the auction are both preceded and followed by more unstable market conditions and higher adverse selection costs, and lead to stronger post-auction price reversions. Our findings contribute to the debate about the benefits and drawbacks of circuit breakers by enlarging the span of these mechanisms studied so far.
Genome-wide SNP analyses reveal population structure of Portunus pelagicus along Vietnam coastline

The blue swimming crab (Portunus pelagicus Linnaeus, 1758) is one of the commercially exploited crab fishery resources in Vietnam. This is the first study to provide a broad survey of genetic diversity, population structure and migration patterns of P. pelagicus along the Vietnamese coastline. The crab samples were collected from northern, central and southern Vietnam. Here, we used a panel of single nucleotide polymorphisms (SNPs) generated from restriction site-associated DNA sequencing (RADseq). After removing 32 outlier loci, 306 putatively neutral SNPs from 96 individuals were used to assess fine-scale population structure of blue swimming crab. The mean observed heterozygosity (Ho) and expected heterozygosity (He) per locus was 0.196 and 0.223, respectively. Pairwise Fst and hierarchical AMOVA supported significant differentiation of central and northern from southern populations (P<0.01). Population structure analyses revealed that P. pelagicus in the south is a separate fisheries unit from the north and center. Contemporary migration patterns supported high migration between northern and central populations and restricted genetic exchange within the southern population. In contrast, historic gene flow provides strong evidence for single panmictic population. The results are useful for understanding current status of P. pelagicus in the wild under an environment changing due to natural and anthropogenic stresses, with implications for fisheries management.
Investigating the prevalence of and factors associated with depressive symptoms among urban and semi-urban school adolescents in Bangladesh: a pilot study

Abstract Background Adolescent depression is an alarming issue for Bangladesh since a large number of Bangladeshi adolescents suffer from depression but cannot get proper treatment. This study aimed to investigate the prevalence of depression and factors associated with this psychological health hazard among urban and semi-urban adolescents of the Dhaka region in Bangladesh. Methods A cross-sectional pilot study was performed among 311 adolescents, grades 8–10, in Dhaka city and Savar Upazila, adjacent to the city, in 2018. Data were collected using a questionnaire consisting of items on sociodemographics, lifestyle information, screen-based sedentary behaviour (SBSB) and mental health. Results A total of 36.6% of the adolescents reported depressive symptoms, with a greater prevalence among females (42.9%) than males (25.7%). Sociodemographic factors including being female, residence and grade in school were significantly associated with depression. Logistic regression analysis showed that SBSBs, such as the use of social media (odds ratio [OR] 2.06 [95% confidence interval {CI} 1.27–3.35]), high screen time (>120 min/day; OR 2.35 [95% CI 1.30–4.25]) and sleep disturbance (OR 3.93 [95% CI 2.37–6.50]) were significantly linked with depressive symptoms. Conclusions Depressive symptoms are prevalent among urban and semi-urban adolescents of Dhaka, Bangladesh. Therefore, urgent initiatives should be taken to curb the spread of depression among Bangladeshi adolescents.
Students’ Need Satisfaction Profiles: Similarity and Change over the Course of a University Semester

Self-determination theory positions the satisfaction of students’ needs for autonomy, competence, and relatedness as important determinants of various educational outcomes. In this study, we identify subpopulations of students characterized by distinct configurations of need satisfaction in the educational context, and assess the extent to which the nature of these configurations, and students’ individual profiles, remain stable over the course of a university semester. We also examine the role of perfectionism in the prediction of profile membership, and how these profiles relate to a variety of educational outcomes. A total of 521 first-year undergraduate university students completed our measures at the beginning and end of a university semester. We identified five need satisfaction profiles, which remained unchanged over the course of the study. Students characterized by higher levels of self-oriented perfectionism were more