Serum Cholesterol, Triglyceride, and Ghrelin Levels in Criminal and Non-criminal Schizophrenia Patients

Amac: Suc kavram›, flahs›n yaflad›¤› toplumdaki mevcut hukuk duzenini bozan, toplumun ahlaki kurallar›n› ihlal eden ve kamunun menfaatine karfl› olan davran›fllar› iceren bir kavramd›r. Psikiyatrik hastal›klar icerisinde sald›rgan davran›fllarla iliflkili hastal›k olarak flizofreni dikkat cekmek- tedir. fiizofrenili hastalarda suc iflleme ve sald›rgan davra- n›fllar uzerinde baz› biyokimyasal parametre duzeylerinin etkili olduu duflunulmektedir. Bu cal›flmada suc ifllemifl ve ifllememifl flizofrenili hastalarda serum kolesterol, trigliserit ve ghrelin duzeylerindeki fakl›l›klar karfl›laflt›r›larak suc uze- rindeki etkilerinin deerlendirilmesi amaclanm›flt›r. Yontem: Cal›flma suresince Elaz›¤ Ruh ve Sinir Hastal›klar› Hastanesinde flizofreni tan›s› alm›fl ve tedavi goren en az bir suc kayd› olan 50 erkek flizofrenili hasta ile herhangi bir suc kayd› olmayan 50 erkek flizofrenili hasta araflt›rmaya al›nd›. Hastalara sosyodemografik bilgi formu uyguland›. Kan or- nekleri, cal›flma kriterlerine uyan hasta ve kontrol gruplar›n- dan sabah 08.00-11.00 saatleri aras›nda al›narak serum to- tal kolesterol, trigliserid ve ghrelin duzeylerine bak›ld›. Bulgular: Suc ifllemifl flizofrenili hastalar ile suc ifllememifl fli- zofrenili hastalar karfl›laflt›r›ld›¤›nda; suc iflleyen flizofrenili hastalar›n serum trigliserit ve ghrelin duzeyleri, suc iflleme- mifl flizofrenili hasta grubuna gore daha yuksek bulundu. Aradaki fark trigliserit ve ghrelinde istatistiksel olarak an- laml›yd›. Serum total kolesterol duzeyleri ise suc ifllemifl olan flizofrenili hastalarda daha dufluk olarak tespit edildi. Arala- r›ndaki bu farkl›l›k istatistiksel olarak anlaml› bulunmad›. Tart›flma: Bulgular›m›z flizofrenili hastalarda suca yatk›nl›k konusunda baz› biyokimyasal parametrelerin duzeylerinin onemli olduunu gosterdi. Suc ifllemede bu parametrele- rin etkinliinin guvenilir bir flekilde kullan›labilmesi icin da- ha ileri cal›flmalara ihtiyac vard›r. Ozellikle kolesterol ve ghrelin duzeylerinin belirlenmesinin suc iflleme eilimi olan flizofreni hastalar›n›n tedavi ve deerlendirmelerinde klinisyenlere katk› salayaca¤›n› duflunmekteyiz. ABSTRACT: cholesterol, triglyceride, and ghrelin levels in criminal and non-criminal schizophrenia patients Objective: Crime is described as actions that disturb the legal order in the community, violate the ethical codes of the society or hinder public interest. Among all psychiatric diseases, schizophrenia is recognized for its association with aggressive behaviors. Some biochemical parameters are considered to induce crime and aggressive behaviors in schizophrenia patients. In this study, we aimed to compare the levels of serum cholesterol, triglyceride, and ghrelin of schizophrenia patients who have committed and not committed a crime and to analyze their effects on commitment of a crime. Method: The current study included 50 schizophrenia patients with at least one record of crime and 50 schizophrenia patients without a crime record that were all diagnosed and treated in Elaz›¤ Mental Hospital. All patients completed a sociodemographic information form. Blood samples for total cholesterol, triglyceride, and ghrelin levels were obtained between 08.00 AM and 11.00 AM. Results: Serum triglyceride and ghrelin levels were higher in the schizophrenia patients that have committed a crime compared to schizophrenia patients that have not committed a crime. Difference between triglyceride and ghrelin levels was statistically significant. Levels of serum total cholesterol were lower in the schizophrenia patients that have committed a crime; however the difference was not statistically significant. Discussion: Our findings have suggested that some biochemical parameters may be important for crime tendency in schizophrenia patients. Further studies are required to confirm the reliability of these parameters for committing a crime. We believe that cholesterol and ghrelin levels will help clinicians for better management of crime tendency in these patients.