Miracle-dz/UniFAR-FTUs huggingface dataset:
SeamCut: interactive mesh segmentation for parameterization

Mesh parameterization consists in unwrapping mesh regions having the topology of a disk onto the 2D plane. This geometry process is fundamental for 2D texture mapping and instrumental for a number of surface analysis primitives. Typically, users execute automatic unwrapping algorithms on handmade disk-like patches, whose design, often called "seaming" induces a massive amount of tedious manual actions to select the edges of the mesh that eventually form the regions boundaries i.e., the seams. We propose SeamCut, an analytic and interactive segmentation framework to build an organized set of curves, cuts and seams, prior to surface parameterization. While the cuts are in charge of dividing the mesh in semantic parts, the seams aim at minimizing parameterization distortion. To tailor them, our method analyzes the surface geometry using only sparse high level interactions on the surface, where we adopt a field-based approach to generate the curves independently of the actual connectivity of the mesh. Once stable, the curve set may be used to remesh the input or snapped to the mesh edges, giving rise to a consistent mesh segmentation ready for automatic parameterization. We evaluate our live surface analysis system on a variety of models and report interactive performances.
Divergence-conforming HDG methods for Stokes flows

In this paper, we show that by sending the normal stabilization function to inﬁnity in the hybridizable discontinuous Galerkin methods pre- viously proposed in [Comput. Methods Appl. Mech. Engrg. 199 (2010), 582–597], for Stokes ﬂows, a new class of divergence-conforming methods is obtained which maintains the convergence properties of the original methods. Thus, all the components of the approximate solution, which use polynomial spaces of degree k , converge with the optimal order of k + 1 in L 2 for any k ≥ 0. Moreover, the postprocessed velocity approximation is also divergence-conforming, exactly divergence-free and converges with order k + 2 for k ≥ 1 and with order 1 for k = 0. The novelty of the analysis is that it proceeds by taking the limit when the normal stabilization goes to inﬁnity in the error estimates recently obtained in [Math. Comp., 80 (2011) 723–760].
Survival analysis in patients with preserved left ventricular function and standard indications for permanent cardiac pacing randomized to right ventricular apical or septal outflow tract pacing.

BACKGROUND Optimal right ventricular (RV) pacing site in patients referred for permanent cardiac pacing remains controversial. A prospective randomized trial was done to compare long-term effect of permanent RV apex (RVA) vs RV outflow tract (RVOT) pacing on the all-cause and cardiovascular mortality. METHODS AND RESULTS A total of 122 consecutive patients (70 men, 69 +/-11 years), with standard pacing indications were randomized to RVA (66 patients) or RVOT (56 patients) ventricular lead placement. After the 10-year follow-up period the mortality data were summarized on the basis of an intention-to-treat analysis. During the long-term follow-up, 31 patients from the RVA group died vs 24 patients in the RVOT group (hazard ratio (HR), 0.96; 95% confidence interval (CI), 0.57-1.65; P=0.89). There were 10 cardiovascular deaths in the RVA and 12 in the RVOT group (HR, 1.04; 95%CI, 0.45-2.41; P=0.93). There were no differences in the all-cause or cardiovascular mortality between the pacing sites after adjustment for age, gender, arterial hypertension, atrial fibrillation, New York Heart Association class and left ventricular end-diastolic diameter. CONCLUSIONS The RVOT provides no additional benefit in terms of long-term survival over RVA pacing.
Treatment of Obstructed Defecation

Abstract Obstructed defecation is a common problem that adversely affects the quality of life for many patients. Known causes of obstructed defecation include pelvic dyssynergy, rectocele, rectal intussusception, enterocele, pelvic organ prolapse, and overt rectal prolapse. Management of this condition requires an understanding of urinary, defecatory, and sexual function to achieve an optimal outcome. The goal of surgical treatment is to restore the various pelvic organs to their appropriate anatomic positions. However, there is a poor correlation between anatomic and functional results. As the pelvis contains many structures, a pelvic support or function defect frequently affects other pelvic organs. Optimal outcomes can only be achieved by selecting appropriate treatment modalities that address all of the components of a patient's problem.
Supporting the Participation of Disabled Children and Young People in Decision-Making.

Increasing children's and young people's participation in decisions, about their own care and about service development, is a policy priority. Although in general participation is increasing, disabled children are less likely to be involved than non-disabled children and it is unclear to what extent children with complex needs or communication impairments are being included in participation activities. This article presents research exploring factors to support good practice in participation and discusses policy and practice implications.
Introduction of a pediatric palliative care curriculum for pediatric residents.

INTRODUCTION The Pediatric Palliative Care Curriculum (PPCC) was introduced as a pilot study in response to the published need for increased pediatric education in end-of-life (EOL) care. The PPCC was designed to better train residents in EOL issues so they could become more comfortable and knowledgeable in caring for children and adolescents with life-threatening illnesses. METHOD The PPCC consisted of six hour-long sessions run by a clinical psychologist, a licensed social worker, and faculty with experience in EOL care. The curriculum repeated every 6 weeks for 1 year. Residents in the training program at Stanford University rotating through oncology, pulmonology, and pediatric intensive care unit (PICU) were invited to attend. Session topics included: (1) personal coping skills, (2) being a caring professional, (3) recognizing cultural and familial differences, (4) pain management, (5) practical issues, and (6) meeting a bereaved parent. Pretest and posttest surveys with five-point Likert scale questions were used to measure curricular impact. RESULTS Statistically significant improvement was found in resident self-report of: feeling prepared to initiate do-not-resuscitate discussions (p </= 0.001), access to nonpharmacologic pain resources (p </= 0.005), exposure to role models who balance medical professionalism and expression of grief (p </= 0.005), ability to address dying patient anxiety (p </= 0.01), administer pain medications (p </= 0.01), initiate organ donation discussions (p </= 0.05), and discuss transition from curative to palliative care (p </= 0.05). Survey ratings for the following topics were unchanged: "expression of grief is unprofessional" and "residency stress prohibits the processing of and coping with grief. " CONCLUSIONS Pediatric residents who participated in this pilot study felt they learned important skills in pediatric EOL care and enhanced their confidence in their ability to care for dying patients and their families. Interventions like the PPCC may be useful at other institutions and aid in the transition to competency-based training.
Performing Identities in Physical Education

Abstract This paper shows how a group of young people and researchers, through their reading of images, performed “identity work” within discourses of the body and gender in physical education. To explore young people's identity narratives and physicality, the researchers used an ethnographic method using photo-elicitation. Findings in this study showed the complex ways girls and boys, picked up, resisted, and negotiated male and female body signifiers by “doing girl” and “doing boy” in the school context. Given these results, the researchers discuss several implications for educators and scholars to consider in working toward the new gender agenda in physical education.
Reproducibility of quantitative cultures of endotracheal aspirates from mechanically ventilated patients

Ventilator-associated pneumonia is frequently diagnosed with quantitative cultures of samples obtained by bronchoscopic techniques, a method associated with high costs and potential adverse effects. Quantitative cultures of endotracheal aspirates are easier and cheaper to obtain, and good correlations between the results of this method and those of bronchoscopic methods have been reported. However, the reproducibility of quantitative cultures of endotracheal aspirates has never been determined. We studied the quantitative analysis of endotracheal aspirates from 21 mechanically ventilated patients taken during two study days with 2- and 6-h intervals between samplings. In all, 40 endotracheal aspirates were obtained. For mechanically ventilated patients, the median variation of quantitative culture results was 12.3% (range, 0 to 63%), corresponding to 0.7 log CFU/ml. Furthermore, variation was independent of the interval of time between samplings. Persistence of significant numbers of pathogens in quantitative cultures (> or = 10(5) CFU/ml) of the consecutive endotracheal aspirates occurred in 82% of samples. We conclude that results of quantitative cultures from endotracheal aspirates are reproducible and may be useful in diagnosing ventilator-associated pneumonia.
The local community perception of tourism development. The case study of Gryfino County – Western Pomerania, Poland

Abstract An increasing number of people from various countries have seen tourism as a chance to develop local economy and quality of life. The article presents the results of the analysis of tourism potential of Gryfino County in Western Pomerania in Poland and confronts them with how it is perceived by the residents. Although the county abounds in great tourist attractions, both of natural and cultural nature and is favourably located in geographic terms, tourism is developing very slowly. In order to examine the reasons for the current situation, an attempt to survey the opinion of the local community on this subject was made by applying the method of Focus Group Interviews. The results emphasise the significance of local community for tourism development in a region.
hSNF5/INI1‐deficient tumours and rhabdoid tumours are convergent but not fully overlapping entities

Rhabdoid tumours (RTs) are rare but highly aggressive tumours of childhood. Their rarity and their miscellaneous locations make the diagnosis particularly challenging for pathologists. Central nervous system and peripheral RTs have been associated with biallelic inactivation of the hSNF5/INI1/SMARCB1 (hSNF5/INI1) tumour suppressor gene. Immunohistochemistry (IHC) with a monoclonal anti‐hSNF5/INI1 antibody has recently been proposed as an efficient diagnostic tool for RTs. We have conducted a retrospective study of 55 tumours referred to our institution with a suspicion of RT. This analysis included pathological review, IHC with anti‐hSNF5/INI1 antibody, and molecular investigation using quantitative DNA fluorescent analysis and sequencing of the nine exons of hSNF5/INI1. The molecular lesion could be detected in 37 of the 39 cases exhibiting negative staining for hSNF5/INI1. In the two discrepant cases, the lack of detection of genetic abnormality was probably owing to the presence of a high number of non‐tumour cells in the samples. This indicates that hSNF5/INI1 IHC is very sensitive and highly specific for the detection of hSNF5/INI1 loss‐of‐function. Among the 38 cases with typical RT histological features, six failed to exhibit hSNF5/INI1 mutation and stained positive for hSNF5/INI1. This strongly supports the evidence of a second genetic locus, distinct from hSNF5/INI1, associated with RT. Conversely, seven tumours with histological features poorly compatible with RT stained negative for hSNF5/INI1; they nevertheless exhibited an age of onset and a clinical behaviour similar to RT. This suggests that hSNF5/INI1 inactivation is not strictly limited to typical RT but characterizes a wider family of hSNF5/INI1‐deficient tumours. Consequently, we believe that anti‐hSNF5/INI1 IHC should be performed widely, even when the pathological characteristics are not typical. The molecular investigation should be performed in infants when a rhabdoid predisposition syndrome is suspected. Copyright © 2006 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Effects of Music on Memory for Text

Previous research has suggested that the use of song can facilitate recall of text. This study examined the effect of repetition of a melody across verses, familiarity with the melody, rhythm, and other structural processing hypotheses to explain this phenomenon. Two experiments were conducted, each with 100 participants recruited from undergraduate Psychology programs (44 men, 156 women, M age = 28.5 yr., SD = 9.4). In Exp. 1, participants learned a four-verse ballad in one of five encoding conditions (familiar melody, unfamiliar melody, unknown rhythm, known rhythm, and spoken). Exp. 2 assessed the effect of familiarity in rhythm-only conditions and of pre-exposure with a previously unfamiliar melody. Measures taken were number of verbatim words recalled and number of lines produced with correct syllabic structure. Analysis indicated that rhythm, with or without musical accompaniment, can facilitate recall of text, suggesting that rhythm may provide a schematic frame to which text can be attached. Similarly, familiarity with the rhythm or melody facilitated recall. Findings are discussed in terms of integration and dual-processing theories.
Self-Compassion as a prospective predictor of PTSD symptom severity among trauma-exposed U.S. Iraq and Afghanistan war veterans.

U.S. combat veterans of the Iraq and Afghanistan wars have elevated rates of posttraumatic stress disorder (PTSD) compared to the general population. Self-compassion, characterized by self-kindness, a sense of common humanity when faced with suffering, and mindful awareness of suffering, is a potentially modifiable factor implicated in the development and maintenance of PTSD. We examined the concurrent and prospective relationship between self-compassion and PTSD symptom severity after accounting for level of combat exposure and baseline PTSD severity in 115 Iraq and Afghanistan war veterans exposed to 1 or more traumatic events during deployment. PTSD symptoms were assessed using the Clinician Administered PTSD Scale for DSM-IV (CAPS-IV) at baseline and 12 months (n =101). Self-compassion and combat exposure were assessed at baseline via self-report. Self-compassion was associated with baseline PTSD symptoms after accounting for combat exposure (β = -.59; p < .001; ΔR(2) = . 34; f(2) = . 67; large effect) and predicted 12-month PTSD symptom severity after accounting for combat exposure and baseline PTSD severity (β = -.24; p = .008; ΔR(2) = . 03; f(2) = . 08; small effect). Findings suggest that interventions that increase self-compassion may be beneficial for treating chronic PTSD symptoms among some Iraq and Afghanistan war veterans.
Red Cell Metabolism. A Manual of Biochemical Methods. 2nd Edition

At last a book on gastrointestinal fibre-optic endoscopy which is not another collection of beautiful photographs, but rather a source of useful information for the practicing endoscopist. This book will be of value to all Endoscopy Units, but particularly to new and developing services. In this rapidly growing field there is need for guidance from an experienced group. Emphasis is placed on the development of an Endoscopy Unit with its own staff trained to properly maintain complex, sophisticated instruments and to assist at specialized procedures. This book contains basic information about the principles of fibre-optic light transmission , technical knowledge of the instruments, application of electrosurgery, all of which will provide the endoscopist with the principles required for the practice of endoscopy. The radiologist will be informed about the relationship of radiology to endoscopy. At times the information becomes of more interest to the nurse-assistant than the physician. However, this information about maintenance of equipment, list of medications, and care of the outpatient is also most valuable. The chapter on tissue handling could be abbreviated, providing information which would be of more value to the histology department than the Endoscopy Unit. In summary, this book compiles, for the first time in the field of gastrointestinal fibre-optic endoscopy, valuable information for all involved in this rapidly growing field of medicine. This volume represents a compilation of the techniques used in the laboratory of Professor Ernest Beutler for the determination of the activities of many red cell enzymes and important metabolic intermediates. The material is clearly and specifically presented. The general discussion of reagents, preparation of hemolysates, and instrumentation will be valuable for those with relatively little biochemical experience. Each method is clearly described; calculations are set forth explicitly. An important feature of the book is that potential pitfalls in each assay are discussed and explained. The last sections of the book present the fluorescent spot tests that Dr. Beutler has utilized as a screening procedure for several enzyme deficiencies. The book is limited in intention. It does not represent a comprehensive discussion of red cell metabolic disorders or of normal red cell metabolism and it is not a complete laboratory manual of hematology, and it in fact contains none of the routine hematologic procedures other than the categories listed above. The book does not attempt to make a systematic comparison or an evaluation of various methods for analysis of a given …
Characterization of Solanum tuberosum Multicystatin and the Significance of Core Domains[C]

This study characterizes the structure and significance of the core of potato multicystatin (PMC), a multidomain cysteine protease inhibitor found in the cortical parenchyma tissue of potato tubers. Papain inhibitory properties of native and recombinant PMC containing core domains are affected by pH. It is likely that pH-mediated regulation imparts unique properties to PMC that modulate proteolysis upon wounding and/or infection via inhibiting cysteine proteases. Potato (Solanum tuberosum) multicystatin (PMC) is a unique cystatin composed of eight repeating units, each capable of inhibiting cysteine proteases. PMC is a composite of several cystatins linked by trypsin-sensitive (serine protease) domains and undergoes transitions between soluble and crystalline forms. However, the significance and the regulatory mechanism or mechanisms governing these transitions are not clearly established. Here, we report the 2.2-Å crystal structure of the trypsin-resistant PMC core consisting of the fifth, sixth, and seventh domains. The observed interdomain interaction explains PMC’s resistance to trypsin and pH-dependent solubility/aggregation. Under acidic pH, weakening of the interdomain interactions exposes individual domains, resulting in not only depolymerization of the crystalline form but also exposure of cystatin domains for inhibition of cysteine proteases. This in turn allows serine protease–mediated fragmentation of PMC, producing ∼10-kD domains with intact inhibitory capacity and faster diffusion, thus enhancing PMC’s inhibitory ability toward cysteine proteases. The crystal structure, light-scattering experiments, isothermal titration calorimetry, and site-directed mutagenesis confirmed the critical role of pH and N-terminal residues in these dynamic transitions between monomer/polymer of PMC. Our data support a notion that the pH-dependent structural regulation of PMC has defense-related implications in tuber physiology via its ability to regulate protein catabolism.
Implications of the United Kingdom Prospective Diabetes Study

: The goal of treatment of type 2 diabetes is to treat early and balance the risk/benefit ratio of aggressive therapeutic intervention for the patient. The results of the UKPDS trial have shown that treatment to improve overall glucose control significantly reduces the risk of microvascular complications and thereby improves the quality of life for persons with diabetes. Optimal medical management includes a team approach and uses continuous communication and education, medical treatment, lifestyle modifications, and behavior changes to improve glycemic control.
Enteroparasite and vivax malaria co-infection on the Brazil-French Guiana border: Epidemiological, haematological and immunological aspects

Malaria-enteroparasitic co-infections are known for their endemicity. Although they are prevalent, little is known about their epidemiology and effect on the immune response. This study evaluated the effect of enteroparasite co-infections with malaria caused by Plasmodium vivax in a border area between Brazil and French Guiana. The cross sectional study took place in Oiapoque, a municipality of Amapá, on the Amazon border. Malaria was diagnosed using thick blood smears, haemoglobin dosage by an automated method and coproparasitology by the Hoffman and Faust methods. The anti-PvMSP-119 IgG antibodies in the plasma were evaluated using ELISA and Th1 (IFN-γ, TNF-α and IL-2), and Th2 (IL-4, IL-5 and IL-10) cytokine counts were performed by flow cytometry. The participants were grouped into those that were monoinfected with vivax malaria (M), vivax malaria-enteroparasite co-infected (CI), monoinfected with enteroparasite (E) and endemic controls (EC), who were negative for both diseases. 441 individuals were included and grouped according to their infection status: [M 6.9% (30/441)], [Cl 26.5% (117/441)], [E 32.4% (143/441)] and [EC 34.2% (151/441)]. Males prevailed among the (M) 77% (23/30) and (CI) 60% (70/117) groups. There was a difference in haemoglobin levels among the different groups under study for [EC-E], [EC-Cl], [E-M] and [Cl-M], with (p < 0.01). Anaemia was expressed as a percentage between individuals [CI-EC (p < 0.05)]. In terms of parasitaemia, there were differences for the groups [CI-M (p < 0.05)]. Anti-PvMSP-119 antibodies were detected in 51.2% (226/441) of the population. The level of cytokines evaluation revealed a large variation in TNF-α and IL-10 concentrations in the co-infected group. In this study we did not observe any influence of coinfection on the acquisition of IgG antibodies against PvMSP119, as well as on the profile of the cytokines that characterize the Th1 and Th2 patterns. However, co-infection increased TNF-α and IL-10 levels.
Institutional Quality, Trade Openness, and Financial Sector Development in Asia: An Empirical Investigation

ABSTRACT We examine the determinants of financial sector development in Asia and the Pacific from 1995 to 2011. In terms of economic growth, over the last twenty years the region has outperformed other parts of the world and has also experienced major developments in its traditionally bank-dominated financial system since the 1997 Asian financial crisis. We apply the dynamic generalized method of moments to a panel data set of twenty-six economies in the region. The estimations were done for the whole panel as well as for subpanels of developed and developing economies. We find that better governance and institutional quality foster financial sector development in developing economies while economic growth and trade openness are key determinants of financial depth in developed economies.
The Effects of Differing Etch Times on the Etch Pattern on Enamel of Unerupted and Erupted Human Teeth Examined using the Scanning Electron Microscope

The etch pattern produced on enamel from unerupted and erupted human teeth with varying periods of acid etching using 37 per cent phosphoric acid was examined using a scanning electron microscope. For erupted enamel etch scores were fairly consistent above 10 seconds etching, for unerupted enamel etch scores matched those for erupted enamel for etch times above 30 seconds. The etch type was more consistent on unerupted enamel.