Miracle-dz/UniFAR-FTUs huggingface dataset:
The Healing Effect of Teucrium polium in Acetic Acid-Induced Ulcerative Colitis in the Dog as an Animal Model

BACKGROUND Inflammatory bowel diseases (IBD), which include ulcerative colitis (UC) and Crohn’s disease (CD), are debilitating and chronic disorders with unpredictable courses and complicated treatment measures. Therefore, an efficient treatment protocol seems necessary as therapeutic prophylaxis for these disorders. This study aims to determine the healing effect of Teucrium polium (T. polium) in acetic acid-induced UC in an experimental dog model. METHODS From September to December 2010, eight male (20-25 kg) crossbred dogs were used for induction of UC by 6% acetic acid, transrectally. After one week, three biopsies (10, 20 and 30 cm proximal to the anal verge) were taken from the colon of each animal for histological studies. In the presence of UC, 400 mg/kg/day of T. polium extract was administered orally and transrectally (via enema) for 30 days in six of the dogs. The remaining two dogs were used as controls and did not receive T. polium. Multiple biopsies were taken 7, 14, and 30 days after discontinuation of T. polium in the same manner as before treatment. RESULTS After administration of acetic acid, we noted the presence of multiple ulcers, diffuse inflammation, PMN infiltration in the lamina propria, glandular destruction and goblet cell depletion. Treatment with T. polium restored the colonic architecture with an increased number of healthy cells and a reduction in inflammatory cells. Damage of the surface epithelial cells and mucosal layer of the lumen were reversed, which lead to faster ulcer healing. CONCLUSION T. polium may be a treatment choice for UC and can broaden the current therapy options for UC.
In Vitro Susceptibility of Characterized β-Lactamase-Producing Strains Tested with Avibactam Combinations

ABSTRACT Avibactam, a broad-spectrum β-lactamase inhibitor, was tested with ceftazidime, ceftaroline, or aztreonam against 57 well-characterized Gram-negative strains producing β-lactamases from all molecular classes. Most strains were nonsusceptible to the β-lactams alone. Against AmpC-, extended-spectrum β-lactamase (ESBL)-, and KPC-producing Enterobacteriaceae or Pseudomonas aeruginosa, avibactam lowered ceftazidime, ceftaroline, or aztreonam MICs up to 2,048-fold, to ≤4 μg/ml. Aztreonam-avibactam MICs against a VIM-1 metallo-β-lactamase-producing Enterobacter cloacae and a VIM-1/KPC-3-producing Escherichia coli isolate were 0.12 and 8 μg/ml, respectively.
The Impact of the Environment on the Management of Information Systems

The dynamic environment of an organization makes management difficult. This is especially true in information systems (IS) departments. A new theoretical model, based on structured interviews with IS executives, proposes ways that some dimensions of the environment create problems for IS management, IS managers develop coping mechanisms to attenuate or prevent these problems. They use these coping mechanisms either to resolve the problems directly or to influence the environment to prevent the problems. The new thoeretical model facilitates an organized study of the relationship between the IS department and its dynamic environment.
Glucosteroid treatment of keratin meningitis following removal of a fourth ventricle epidermoid tumour.

ItwasCruveilhier in1829whogavethepicturesque description of intracranial keratinous tumours, 'tumeurs perlees'. Bailey described thefirst successfulremoval ofanintracranial pearly tumourin1920. Inthesecond casereported inthat paperandintwo subsequent casesreported byBailey in1924in which only asubtotal removal ofthis lesion could be safely effected, thepost- operative coursewas complicated byspiking fever andmeningismus, but repeated cultures ofthecerebrospinal fluid were negative. Theaseptic orchemical aetiology ofthis meningitic syndrome following removal ofthese tumourshas beenamplydocumented. Inallinstances thecommon factor inthepathogenesis ofthemeningeal reaction hasappeared tobethecontamination ofthe subarachnoid spacebytumourcontents. Recently, a report wasmadeofa caseofkeratin chemical meningitis following theremoval ofaposterior fossa dermoid. A simple testinvolving microscopic examination of thecerebrospinal fluidunder polarized light afforded identification ofthepresence ofbirefringent keratin inthecerebrospinal fluid (Cantu, Moses,Kjellberg, andConnelly, 1966). Thistestalsoconfirmed thepresence ofkeratin in thelumbar cerebrospinal fluid inthefollowing case, whichisbeingreported toillustrate thestriking therapeutic value ofglucocorticoids inthetreatment ofaseptic chemical meningitis.
A Human Homolog of Angiotensin-converting Enzyme

A novel human zinc metalloprotease that has considerable homology to human angiotensin-converting enzyme (ACE) (40% identity and 61% similarity) has been identified. This metalloprotease (angiotensin-converting enzyme homolog (ACEH)) contains a single HEXXH zinc-binding domain and conserves other critical residues typical of the ACE family. The predicted protein sequence consists of 805 amino acids, including a potential 17-amino acid N-terminal signal peptide sequence and a putative C-terminal membrane anchor. Expression in Chinese hamster ovary cells of a soluble, truncated form of ACEH, lacking the transmembrane and cytosolic domains, produces a glycoprotein of 120 kDa, which is able to cleave angiotensin I and angiotensin II but not bradykinin or Hip-His-Leu. In the hydrolysis of the angiotensins, ACEH functions exclusively as a carboxypeptidase. ACEH activity is inhibited by EDTA but not by classical ACE inhibitors such as captopril, lisinopril, or enalaprilat. Identification of the genomic sequence of ACEH has shown that the ACEH gene contains 18 exons, of which several have considerable size similarity with the first 17 exons of human ACE. The gene maps to chromosomal location Xp22. Northern blotting analysis has shown that the ACEH mRNA transcript is ∼3.4 kilobase pairs and is most highly expressed in testis, kidney, and heart. This is the first report of a mammalian homolog of ACE and has implications for our understanding of cardiovascular and renal function.
Clinical course of patients with aplastic anemia or myelodysplastic syndrome associated with persistent neutropenia

Patients with aplastic anemia (AA) or myelodysplastic syndrome (MDS) often have persistent severe neutropenia and are susceptible to infectious complications. We retrospectively reviewed the clinical course of patients with AA or MDS who had neutropenia (neutrophil count < 500/µl) for more than 25 days. A total of 46 patients, 11 with AA and 35 with MDS, were included. Twenty‐three patients had infectious events (IE), and the cumulative incidence of IE was 30% at 6 months and 51% at 1 year. The cumulative incidence of IE was 67% at 1 year in 30 patients who experienced very severe neutropenia of less than 200/µl. Overall survival in all patients was 76% at 6 months and 65% at 1 year. In a multivariate analysis, male sex, underlying diseases, and a neutrophil count of less than 200/µl as a time‐dependent covariate significantly affected IE. In analyses that excluded patients with AA, male sex was the only factor. In conclusion, severe neutropenia was significantly associated with IE in patients with AA or MDS, and IE might be lethal. When we only considered patients with MDS, the neutrophil count alone could not be used to predict the prognosis. Copyright © 2011 John Wiley & Sons, Ltd.
Costs and Benefits of Building Green

Definitions of sustainability range from broad concepts that incorporate all aspects of sustainability to narrow definitions focused on one specific sustainable feature, such as recycled content materials or energy efficiency. The American Society of Civil Engineers defines sustainable development as “. the challenge of meeting human needs for natural resources, industrial products, energy, food, transportation, shelter, and waste management while conserving and protecting environmental quality and the natural resource base essential for future development. ” [1] What, then, constitutes ‘greenness’? Sustainable construction is a philosophy and an integrated design process, not a building style. The definition of ‘what is green’ varies according to the source, and may be subjective – for the purposes of this paper (while acknowledging that certification methodologies have flaws and continue to evolve), the US Green Building Council criteria will be assumed to best define a green building.
'Evaluating B-type Natriuretic Peptide Levels in Patients with Non-ST Segment Elevation Myocardial Infarction' (ST Elevasyonu Olmayan Miyokard Enfarktüslü Hastalarin B-Tipi Natriüretik Peptid Düzeylerinin Değerlendirilmesi) Research Article (Araştirma Makalesi)

Background: We compared the B-type natriuretic peptide levels in patients with non ST-segment elevation myocardial infarction, with the levels in the healthy control group. Methods: A prospective study was conducted in the emergency department. Thirty patients with non ST-segment elevation myocardial infarction and 29 healthy control subjects were included in the data analysis. We sampled B-type natriuretic peptide at up to 3 time points within 72 h of presentation (0-24, 24-48 and 48-72 hours) and the testing was performed using microparticle enzyme immunoassay method. Results: Median B-type natriuretic peptide, cardiac troponin I and creatine kinase MB levels were significantly higher in patients with non ST-segment elevation myocardial infarction than control group (p<0.05). According to the receiver operating curve analysis; area under the curve calculated for cardiac troponin I, creatine kinase MB and B-type natriuretic peptide (0-24 h), (24-48 h), (48-72 h) were 0.980, 0.973, 0.640, 0.660, and 0.644 respectively. We found a weak correlation between B-type natriuretic peptide (24-48 h) and both troponin I (r =0.321, p<0.05) and creatine kinase MB (r =0.347, p<0.01) levels. Conclusions: B-type natriuretic peptide does not look as a valuable test for the diagnosis of non ST-segment elevation myocardial infarction. It might be a useful adjunct to standard cardiac markers in patients with non ST-segment elevation myocardial infarction. Further larger scaled studies are required.
The dependence on zenith angle of the strength of 3‐meter equatorial electrojet irregularities

Radar measurements in Peru were used to deduce the zenith angle dependence of the scattering cross section of plasma irregularities generated by instabilities in the equatorial electrojet. The irregularities probed by the 50 MHz Jicamarca radar had a wavelength of 3m. The cross section for the type 2 irregularities was isotropic in the plane perpendicular to the magnetic field, while the cross section for the stronger type 1 irregularities varied with zenith angle at a rate of approximately 0.3 dB/degree; the horizontally traveling waves were more than 100 times stronger than those traveling vertically.
Clinical significance of the effects of thiopentone and adjuvant drugs on blood sugar and glucose tolerance.

IT has been shown, both in a previous communication (Dundee, 1956) and from the findings of other workers, that thiopentone produces no appreciable change in the blood sugar levels in man. Slight hyperglycaemia resulted when thiopentone nitrous oxide-oxygen anaesthesia, followed morphia and atropine as premedication for operations on varicose veins. The rise in blood sugar during operation differed significantly from that produced by thiopentone alone, and it was suggested that this may have been secondary to respiratory depression produced by the morphiathiopentone combination. It was also shown, in the same publication, that thiopentone impairs the ability of the body to deal with an extra load of glucose. Goldsmith and Holmes (1957) have also found that a slightly greater degree of hyperglycaemia resulted from intravenous injections of dextrose given to patients under thiopentone anaesthesia than from the same dose given to the same subjects in the conscious state. This paper is concerned with the significance of these effects of thiopentone-nitrous oxideoxygen anaesthesia, as applied to routine anaesthetic practice. The effects of pre-operative medication and adjuvants given during thiopentone—nitrous oxide-oxygen anaesthesia are reported.
ICF Core Set for patients with neurological conditions in the acute hospital

Purpose: The aim of this consensus process was to decide on a first version of the ICF Core Set for patients with neurological conditions in the acute hospital. Methods: The ICF Core Set development involved a formal decision-making and consensus process, integrating evidence gathered from preliminary studies including focus groups of health professionals, a systematic review of the literature and empiric data collection from patients. Results: Twenty-one experts selected a total of 85 second-level categories. The largest number of categories was selected from the ICF component Body Functions (41 categories or 48%). Five (6%) of the categories were selected from the component Body Structures, 18 (21%) from Activities and Participation and 21 (25%) from Environmental Factors. Conclusions: The Acute ICF Core Set for patients with neurological conditions provides all professionals with a clinical framework to comprehensively assess patients in the acute hospital. This first ICF Core Set will be further tested through empiric studies in German-speaking countries and internationally.
Preliminary Perceived Voice Deviations and Hearing Disorders of Adults with Down's Syndrome

It has been noted that Down's syndrome children have voice disorders in pitch and that the perceived quality parameters of their voices are also deviant (2, 3 ) . but few acoustical or objective perceptual data are available concerning the voices of such adults. The collection of extensive family, environmental, medical, physical. and nutritional data from 51 adults (over age 1 6 ) with Down's syndrome was undertaken. Verbal samples of the subjects' voices were obtained in a double-walled, sound-treated booth with a high quality microphone and tape recorder at a transport speed of 15 ips. Each recorded verbal sample was approximately 15 min. long. Two trained listeners independently rated these voices from the tapes and concurred in most cases. Most subjects' voices were rated as "breathy. " Othcr verbal deviations included lower and higher pitch levels in comparison to the subjects' sex and age and inappropriate balance of oral and nasal resonance. Also, pure tone threshold hearing tests were administered using techniques of professional audiologists. Middle-ear impedance audiometry was performed using a GrasonStadler impedance bridge. Preliminary data suggest that about 75% ( n = 3 8 ) of the subjects who could be tested had significant hear~ng losses (25-dB loss or worse by pure tone average method in the better ear ) . Most hearing losses appeared to be of a conductive nature although there were a number of sensorineural and mixed losses. Final results may indicate that subjects with more pronounced voice disorders have more serious hearing disabilities. Deaf children d o have deviant voices due to their hearing disabilities (1) and subsranr~al hearing impairments can adversely affect reception and acquisition of spoken language ( 4 ) . Production of spoken language, including the vocal parameters of quality, intens~ry, and the pitch of the voice is affected by inability to monitor one's own speech ( 5 ) . Adults with Down's syndrome are more likely to have deviant voices as hearing impairment tends to break the feedback loop of the speech chain. Their hearing should be screened frequently and ocological/audiological management planned. When otological management will be of long duration, amplification and aural rehabilitation may be indicated as an adjunctive therapeutic procedure. At present acoustical data are being obtained from the tape recordings, and a tape with short verbal samples from each subject is being prepared for perceptual ratings by groups of trained listeners.
Mmpis of Hispanic, Black, and White DSM-III Schizophrenics

The purpose of this study was to compare the MMPI performance of Hispanic, black, and white mental patients who were matched on the psychiatric diagnosis of schizophrenia. It was hypothesized that ethnic patient groups from a maximum security hospital would not differ significantly on any of the 13 MMPI scales as a result of being equated on psychiatric diagnosis. A secondary purpose was to examine the most frequently occurring two-point high-point codes elicited by each of the ethnic groups. Significant multivariate differences were indicated among the MMPI scales and across ethnic groups. Significant univariate differences were found among the three ethnic groups on six of the 13 MMPI scales. The most frequently occurring two-point high-point code for Hispanic and white groups was the “8-2/2-8” code, while for the black group it was the “6-8/8-6” code. Results were discussed with regard to ethnicity, psychiatric diagnosis, and MMPI performance of ethnic/racial groups.
Regulation of Inositol Metabolism Is Fine-tuned by Inositol Pyrophosphates in Saccharomyces cerevisiae*♦

Background: Regulation of inositol metabolism is crucial for cellular functions. Results: Inositol pyrophosphate-deficient cells exhibit defective inositol biosynthesis. Protein levels of the inositol pyrophosphate biosynthetic enzyme Kcs1 are dynamically altered in response to inositol. Conclusion: INO1 transcription and inositol biosynthesis are regulated by modulation of inositol pyrophosphate synthesis. Significance: Inositol pyrophosphates are novel regulators of biosynthesis of inositol and inositol phospholipids. Although inositol pyrophosphates have diverse roles in phosphate signaling and other important cellular processes, little is known about their functions in the biosynthesis of inositol and phospholipids. Here, we show that KCS1, which encodes an inositol pyrophosphate kinase, is a regulator of inositol metabolism. Deletion of KCS1, which blocks synthesis of inositol pyrophosphates on the 5-hydroxyl of the inositol ring, causes inositol auxotrophy and decreased intracellular inositol and phosphatidylinositol. These defects are caused by a profound decrease in transcription of INO1, which encodes myo-inositol-3-phosphate synthase. Expression of genes that function in glycolysis, transcription, and protein processing is not affected in kcs1Δ. Deletion of OPI1, the INO1 transcription repressor, does not fully rescue INO1 expression in kcs1Δ. Both the inositol pyrophosphate kinase and the basic leucine zipper domains of KCS1 are required for INO1 expression. Kcs1 is regulated in response to inositol, as Kcs1 protein levels are increased in response to inositol depletion. The Kcs1-catalyzed production of inositol pyrophosphates from inositol pentakisphosphate but not inositol hexakisphosphate is indispensable for optimal INO1 transcription. We conclude that INO1 transcription is fine-tuned by the synthesis of inositol pyrophosphates, and we propose a model in which modulation of Kcs1 controls INO1 transcription by regulating synthesis of inositol pyrophosphates.
Customer Adoption of Mobile Payment Services by Professionals across two Cities in India: An Empirical Study Using Modified Technology Acceptance Model

The purpose of this paper is to investigate the factors involved in adoption of a new innovation by consumers specifically in the mobile payment services context. With the mobile penetration of nearly 70% in India, mobile payments services have huge potential in the country; however, customer adoption of mobile payment systems is very low. Therefore, there is a need for research to identify the factors affecting consumer intention to use mobile payment systems. To get meaningful comprehensive insights on customers' perception and usage intention of mobile payment systems, current research validates a model based on Technology Acceptance Model (TAM) using a sample of urban population from two metros in India. The empirical findings indicate that the constructs of performance expectancy, effort expectancy, social influence and facilitating conditions have significant impact on mobile payment services adoption among the consumers. This study provides insights into mobile payment services in India which has not been investigated well. Also, there is lack of studies which connect consumer attitudinal factors like performance expectancy, effort expectancy, social influence and facilitating conditions in the e-finance and mobile finance context especially in India.
Viscous tilting and production of vorticity in homogeneous turbulence

Viscous depletion of vorticity is an essential and well known property of turbulent flows, balancing, in the mean, the net vorticity production associated with the vortex stretching mechanism. In this letter, we, however, demonstrate that viscous effects are not restricted to a mere destruction process, but play a more complex role in vorticity dynamics that is as important as vortex stretching. Based on the results from three dimensional particle tracking velocimetry experiments and direct numerical simulation of homogeneous and quasi-isotropic turbulence, we show that the viscous term in the vorticity equation can also locally induce production of vorticity and changes of the orientation of the vorticity vector (viscous tilting).
Evaluation of the validity of Hb A2 and mean corpuscular haemoglobin action values in antenatal screening for beta thalassaemia carriers in England

National antenatal screening of all pregnant women in England is carried out using standards and guidelines produced by the National Health Service Sickle Cell and Thalassaemia Screening Programme. The algorithms for detection of beta thalassaemia carrier status rely on action criteria, which are set using the percentage Hb A2 and mean corpuscular haemoglobin (MCH) values. Three groups of samples: MCH <27 pg and Hb A2 3·5–3·9%, MCH ≥27 pg and Hb A2 4–4·3% and MCH ≥27 pg and Hb A2 3·5–3·9% were selected from a sample population of 59 500 to assess the validity and predictive value of the action criteria – 25 false positives (0·042% of total) and nine false negatives (0·015% of total) were detected. These findings support the continuation of the current action values.