Miracle-dz/UniFAR-FTUs huggingface dataset:
Ontology alignment based on instance using NSGA-II

Nowadays, ontologies are widely used to solve data heterogeneity problems on the Semantic Web. However, simple use of these ontologies may raise the heterogeneity problem to a higher level. Addressing this problem requires identification of correspondences between the entities of various ontologies. Since the real semantics of a concept is often better defined by the actual instances assigned to it, instance, as an important element of ontology, contains a great quantity of knowledge that should be utilized to obtain the ontology alignment. To this end, in this paper, we propose a novel instance-based aligning approach using NSGA-II to determine the optimal instance correspondences and a similarity propagation algorithm that makes use of various semantic relations to propagate the similarity values to other entities of ontologies. The experiment of comparing our approach with the participants of OAEI 2012 has demonstrated that our method is an effective approach that can obtain the alignment with high precision value.
Quantitative dose-volume response analysis of changes in parotid gland function after radiotherapy in the head-and-neck region.

PURPOSE To study the radiation tolerance of the parotid glands as a function of dose and volume irradiated. METHODS AND MATERIALS One hundred eight patients treated with primary or postoperative radiotherapy for various malignancies in the head-and-neck region were prospectively evaluated. Stimulated parotid flow rate was measured before radiotherapy and 6 weeks, 6 months, and 1 year after radiotherapy. Parotid gland dose-volume histograms were derived from CT-based treatment planning. The normal tissue complication probability model proposed by Lyman was fit to the data. A complication was defined as stimulated parotid flow rate <25% of the preradiotherapy flow rate. RESULTS The mean stimulated preradiotherapy flow rate of 174 parotid glands was 0.34 mL/min. The mean flow rate reduced to 0.12 mL/min 6 weeks postradiotherapy, but recovered to a mean flow rate of 0.20 mL/min at 1 year after radiotherapy. Reduction in postradiotherapy flow rate correlated significantly with mean parotid dose. No threshold dose was found. Increasing the irradiated volume of parotid glands from 0%-40% to 90-100% in patients with a mean parotid dose of 35-45 Gy resulted in a decrease in flow ratio from, respectively, approximately 100% to less than 10% 6 weeks after radiation. The flow ratio of the 90%-100% group partially recovered to 15% at 6 months and to 30% at 1 year after radiotherapy. The normal tissue complication probability model parameter TD(50) (the dose to the whole organ leading to a complication probability of 50%) was found to be 31, 35, and 39 Gy at 6 weeks, 6 months, and 1 year postradiotherapy, respectively. The volume dependency parameter n was around 1, which means that the mean parotid dose correlates best with the observed complications. There was no steep dose-response curve (m = 0.45 at 1 year postradiotherapy). CONCLUSIONS This study on dose/volume/parotid gland function relationships revealed a linear correlation between postradiotherapy flow ratio and parotid gland dose and a strong volume dependency. No threshold dose was found. Recovery of parotid gland function was shown at 6 months and 1 year after radiotherapy. In radiation planning, attempts should be made to achieve a mean parotid gland dose at least below 39 Gy (leading to a complication probability of 50%).
Transforming women’s rehabilitation? An early assessment of gender-specific provision in three Community Rehabilitation Companies

Following the implementation of the Offender Rehabilitation Act 2014, the Transforming Rehabilitation (TR) reforms expanded the offender management market to include several private providers, known as Community Rehabilitation Companies (CRCs). The TR reforms have been the subject of intense debate since the outset. Political, academic and campaign-group commentary has critiqued the rapid implementation of the new agenda and examined its likely impact on existing services (particularly those run by the charitable sector). A growing body of research has also questioned the likely impact of the legislation on community provision for women, a field already beset with precarious funding streams. Drawing on 36 interviews conducted with probation officers and practitioners (keyworkers) working for women’s services, this article validates such concerns. While the supposed subjects of an established government strategy, it is particularly regretful to report such findings in the 10th anniversary year of Baroness Corston’s seminal report.
Graph-based visual SLAM and visual odometry using an RGB-D camera

In this paper we present a real-time graph-based visual SLAM approach. The presented visual SLAM algorithm can be separated into three parts: feature extraction, data association, and SLAM back-end. We use FAST for feature detection and the Binary Robust Independent Elementary Features (BRIEF) as feature descriptor, which together provide a fast and stable feature extraction. The data association is solved using Locality Sensitive Hashing (LSH), which uses local hash tables and profits from binary feature descriptors. As SLAM back-end we use the general graph optimization framework g2o, which is designed to provide solutions to several SLAM variants. We further provide a novel approach to visual odometry by combining recent sensor measurements into a small pose graph and optimizing it using g2o. For finding potential neighbour nodes and loop closures we introduce the Global Feature Repository (GFR). GFR searches for loop closures and potential neighbours independent of their position in the graph. Finally, we show the accuracy and real-time ability of our algorithm by comparing it to a recently published benchmark dataset. We further provide some large-scale datasets using state-of-the-art laser localization as ground-truth.
Assessing the psychological predictors of benefit finding in patients with head and neck cancer

Some individuals are able to gain psychological benefits from illness and adversity, such as a greater sense of purpose and closer relationships, termed ‘benefit finding’ (BF). The main aim of this study was to explore the extent to which BF is reported in patients with head and neck cancer (HNC). Secondary aims were to establish the relationships between BF, other patient‐reported outcomes and predictive factors such as coping strategy and level of optimism.
Histologic Assessment of Lichenoid Dermatitis Observed in Patients With Advanced Malignancies on Antiprogramed Cell Death–1 (anti–PD-1) Therapy With or Without Ipilimumab

Abstract: Lichenoid drug reaction is a common adverse reaction in patients taking immune-modulatory agents such as antiprogramed cell death (PD-1) and cytotoxic T lymphocyte antigen–4 agents. The authors describe the clinical and histologic features of lichenoid drug reaction in 20 biopsies from 15 patients on anti–PD-1 agents and 9 biopsies from 7 patients on anti–PD-1 plus ipilimumab therapy. Clinically, all except 2 patients presented with discrete, violaceous exanthematous papules to plaques. The lichenoid inflammation in the majority (18 of 29 biopsies) was florid although histology was quite heterogeneous. Nevertheless, there was frequent involvement of the superficial follicular epithelium and acrosyringium, and also a propensity to blister that occurred in approximately 20% of the biopsies. Occasional patients had disease closely resembling lichen planus, although all of these biopsies had some atypical features for lichen planus such as parakeratosis. Dermal eosinophils were common particularly in those with mild inflammation. The lichenoid reaction was responsive to topical steroid or oral systemic treatment in general, and the anti–PD-1 agent had to be ceased in only one patient.
Using Deliberative and Qualitative Methods to Mobilize Community Around the Mental Health Needs of Rural African Americans

Abstract Abstract—Deliberative methods obtain informed and well-reasoned public input on health topics but are rarely accompanied by rigorous qualitative methods that can ground findings in community members’ shared experiences. In this project, we used Deliberative Democracy Forums, a deliberative process, to bring diverse community members together to collectively discuss mental health among rural African Americans, brainstorm solutions to address mental health needs, deliberate alternate solutions, and indicate steps for future action. By using rigorous qualitative methods to document the deliberative process and analyze deliberative dialogue, we produced a strong evidence base to inform future health care policy and research. In this article, we document our approach, present forum findings, and discuss the impact of deliberation on policy and research. We conclude that the combination of deliberative process and qualitative methods used in our project can produce a deeply contextualized understanding of mental health and identify community-initiated solutions to address mental health needs in resource-poor communities, which can help guide public health research and provide an evidence base for public health policy.
Relation between cell disruption conditions, cell debris particle size, and inclusion body release

The efficiency of physical separation of inclusion bodies from cell debris is related to cell debris size and inclusion body release and both factors should be taken into account when designing a process. In this work, cell disruption by enzymatic treatment with lysozyme and cellulase, by homogenization, and by homogenization with ammonia pretreatment is discussed. These disruption methods are compared on the basis of inclusion body release, operating costs, and cell debris particle size. The latter was measured with cumulative sedimentation analysis in combination with membrane‐associated protein quantification by SDS‐PAGE and a spectrophotometric peptidoglycan quantification method. Comparison of the results obtained with these two cell debris quantification methods shows that enzymatic treatment yields cell debris particles with varying chemical composition, while this is not the case with the other disruption methods that were investigated. Furthermore, the experiments show that ammonia pretreatment with homogenization increases inclusion body release compared to homogenization without pretreatment and that this pretreatment may be used to control the cell debris size to some extent. The enzymatic disruption process gives a higher product release than homogenization with or without ammonia pretreatment at lower operating costs, but it also yields a much smaller cell debris size than the other disruption process. This is unfavorable for centrifugal inclusion body purification in this case, where cell debris is the component going to the sediment and the inclusion body is the floating component. Nevertheless, calculations show that centrifugal separation of inclusion bodies from the enzymatically treated cells gives a high inclusion body yield and purity. © 2004 Wiley Periodicals, Inc.
Prevalent platelet dysfunction in patients with aortic valve disease.

BACKGROUND AND AIM OF THE STUDY In patients with heart valve disease, the valve leaflets display a gapped, rough endothelial lining often covered with calcified areas. As a consequence, blood flow is disturbed and a stimulation of components of the hemostasis system is assumed. The possible mechanisms of this process are, however, unclear at present. METHODS Platelet function was studied in 660 patients considered for isolated coronary artery bypass graft (CABG) surgery, and in 421 patients considered for single aortic valve replacement (AVR). Platelet function was monitored preoperatively using the platelet function analyzer device (PFA-100). The test results were reported as closure time of the membrane hole at the end of a capillary tube. The von Willebrand factor antigen, and its collagen-binding activity, were also determined among subgroups of 40 AVR and 50 CABG candidates. RESULTS Platelet dysfunction was displayed by only 22% of CAD patients, but by 83% of AVR candidates. The mean PFA closure time in AVR patients was considerably higher than in CAD patients (231 +/- 59 s versus 153 +/- 60 s, respectively; p < 0.01). The mean platelet volume, platelet distribution width and von Willebrand factor collagen binding and antigen levels did not differ between the patient groups. CONCLUSION It is assumed that, due to disturbed flow and shear exposition, following an initial activation, the platelets are partially degranulated, shed microparticles, and might become involved in the pathogenesis of microvascular dysfunction and thrombotic events in patients with aortic valve disease.
Relationships of urinary phyto‐oestrogen excretion to BMD in postmenopausal women

objective Phyto‐oestrogens are plant compounds with both oestrogenic and anti‐oestrogenic properties. However, it is not known whether natural phyto‐oestrogens are beneficial or harmful in human osteoporosis. This study was performed to investigate the relationships between urinary phyto‐oestrogens and bone mineral density (BMD) in Korean postmenopausal women.
Dual-Path Convolutional Image-Text Embedding

This paper considers the task of matching images and sentences. The challenge consists in discriminatively embedding the two modalities onto a shared visual-textual space. Existing work in this field largely uses Recurrent Neural Networks (RNN) for text feature learning and employs off-the-shelf Convolutional Neural Networks (CNN) for image feature extraction. Our system, in comparison, differs in two key aspects. Firstly, we build a convolutional network amenable for fine-tuning the visual and textual representations, where the entire network only contains four components, i.e., convolution layer, pooling layer, rectified linear unit function (ReLU), and batch normalisation. End-to-end learning allows the system to directly learn from the data and fully utilise the supervisions. Secondly, we propose instance loss according to viewing each multimodal data pair as a class. This works with a large margin objective to learn the inter-modal correspondence between images and their textual descriptions. Experiments on two generic retrieval datasets (Flickr30k and MSCOCO) demonstrate that our method yields competitive accuracy compared to state-of-the-art methods. Moreover, in language person retrieval, we improve the state of the art by a large margin. Code is available at this https URL com/layumi/Image-Text-Embedding
Gabapentin augmentation therapy in bipolar depression.

BACKGROUND Gabapentin (GBP) may be useful in bipolar disorders, including as adjunctive therapy for bipolar depression, although controlled studies suggest inefficacy as primary treatment for mania or treatment-resistant rapid cycling. METHODS We performed a 12-week trial of open GBP (mean dose 1725 mg/day) added to stable doses of mood stabilizers or atypical antipsychotics in 22 (10 women, mean age 38.4 years) depressed (28-item Hamilton Depression Rating Scale (HDRS) > 18] bipolar (10 bipolar I, 12 bipolar II) disorder outpatients. Mean illness duration was 18.6 years, current depressive episode duration was 18.0 weeks. Prospective 28-item HDRS, Young Mania Rating Scale (YMRS) and Clinical Global Impression-Severity (CGI-S) ratings were obtained. RESULTS Overall, HDRS ratings decreased 53% from 32.5 +/- 7.7 at baseline to 16.5 +/- 12.8 at week 12 (p < 0.0001). Twelve of 22 (55%) patients had moderate to marked improvement (HDRS decrease = 50%) with HDRS decreasing 78% from 27.9 +/- 6.2 to 6.2 +/- 4.5 (p < 0.0001). Eight of 22 (36%) patients remitted (HDRS > or = 8). In non-responders, HDRS decreased from 38.0 +/- 5.4 to 28.9 +/- 6.7 (p = 0.005). Ten of 13 (77%) mild to moderately depressed (baseline HDRS > 18 and <35) patients responded, while only two of nine patients (22%) with severe depression (HDRS > or = 35) responded (p < 0.03). Both groups, however, had similar, statistically significant HDRS decreases. GBP was well tolerated. CONCLUSION Open adjunctive GBP was effective and well tolerated in patients with mild to moderate bipolar depression. This open pilot study must be viewed with caution, and randomized controlled studies are warranted.
Autoantibodies to tumor-associated antigens as diagnostic biomarkers in hepatocellular carcinoma and other solid tumors

Liver cancer, especially hepatocellular carcinoma (HCC), is one of the most common tumors worldwide. The majority of people with HCC will die within 1 year of its detection. The high case–fatality rate can, in part, be attributed to a lack of diagnostic methods that enable the early detection of liver cancer. Hence, there is a need for further understanding of tumor biology and host response mechanisms so that new diagnostic and therapeutic tools can be developed. There has been a growing interest in using serum anti-tumor-associated antigen (TAA) antibodies as serological cancer biomarkers. This interest stems from the notion that these anti-TAA antibodies are ‘sensors’ or ‘reporters’ of molecular events associated with tumorigenesis. The persistence and stability of autoantibodies in the serum of cancer patients is an advantage over other potential markers, including the TAAs themselves, some of which are released by tumors but rapidly degrade or are cleared after circulating in the serum for a limited time. Furthermore, the widespread availability of methods and reagents to detect serum autoantibodies facilitates their characterization in cancer patients and assay development. The hypothesis is that ‘customized’ TAA arrays constitute promising and powerful tools for enhancing the serological anti-TAA antibody detection of cancer. The present review will focus on the recent advances in our studies primarily associated with the idea and possibility that autoantibodies to TAAs can be used as biomarkers in immunodiagnosis of HCC and other solid tumors.
The revitalization of the dual system of vocational training in Germany

This chapter is part of a book that provides a detailed comparative analysis of the vocational training systems in 10 different countries, based on the results of a research project undertaken between 2005 and 2007. The analytical perspective adopted investigated the organising principles of each national vocational training system, its links with general education, further training and the labour market, and the strengths and weaknesses of each system. Innovations introduced over the past decade were given particular attention. In this chapter, the author describes and analyses the changes in the vocational training system of Germany over the past two decades, focusing on the dual system, the most important part of the training system. Aspects covered include the structure of the system, revision of training ordinances, financing, the willingness of companies to provide training, links between vocational training and the labour market, and future challenges facing the system.
Evaluation of pirimiphos-methyl (50% EC) against the immatures of Anopheles stephensi/An. culicifacies (malaria vectors) and Culex quinquefasciatus (vector of bancroftian filariasis).

BACKGROUND & OBJECTIVES In India, temephos and fenthion are used as larvicides in fresh and polluted waters. Since use of same insecticide may precipitate resistant, as an alternative bioefficacy of pirimiphos-methyl--an organophosphorus insecticide was evaluated against immatures of Anopheles and Culex species in different breeding habitats in District Ghaziabad (U.P.) and Goa. METHODS Laboratory bioassays were carried out using standard WHO procedure. LC50 and LC90 were calculated using Probit analysis. Abbott's formula was used to calculate per cent corrected mortality in laboratory exposures while, Mulla's formula was applied for calculating per cent reduction in mosquito immatures under field conditions. RESULTS Pirimiphos-methyl was found to be most effective against larvae of An. stephensi followed by An. culicifacies and Cx. quinquefasciatus. The LC50 and LC90 values against three species were 0.023, 0.032 and 0.04 ppm; and 0.045, 0.057 and 0.114 ppm respectively. In field, pirimiphos-methyl @ 200 g a.i./ha against Anopheles species and @ 300 g a.i./ha against Culex species can produce > 80% reduction in density of immatures up to one week in different habitats. Pirimiphos-methyl < 0.25 ppm is not toxic to fish. INTERPRETATION & CONCLUSION Pirimiphos-methyl is more effective against anophelines in clean water than culicines in polluted water. This larvicide should not be used at a concentration above 0.25 ppm in habitats harbouring the larvivorous fish.
Growth, Tolerance and Biochemical Measures in Healthy Infants Fed a Partially Hydrolyzed Rice Protein-Based Formula: A Randomized, Blinded, Prospective Trial

Objective: To evaluate growth, tolerance and plasma biochemistries in infants fed an experimental rice protein-based infant formula. Design: Randomized, blinded, 16 week parallel feeding trial of 65 healthy infants fed either an experimental partially hydrolyzed rice protein-based infant formula fortified with lysine and threonine (RPF, n = 32), or a standard intact cow’s milk protein-based formula (CMF, n = 33) as a control. Assessments occurred at enrollment (average 2 days), 2, 4, 8, and 16 weeks of age. Results: Growth as indicated by weight, length, and head circumference was not different between the 2 formula groups. All plasma biochemistries for both groups were within reference normal range. However, RPF group had lower phosphorus and urea nitrogen, lower essential amino acids except threonine, which was higher, and lower ratio of essential (including semi-essential) to non-essential amino acids. Differences in the concentrations and ratios of amino acids became less as feeding progressed with age. Plasma total protein, albumin, prealbumin, calcium, magnesium, and alkaline phosphatase were not different between groups. Conclusion: Healthy infants fed an experimental partially hydrolyzed rice protein-based formula had normal growth, tolerance, and plasma biochemistry comparable to those of infants fed a standard intact milk protein-based formula, despite some differences in amino acid profiles.
Improved Three-Phase Current Reconstruction for Induction Motor Drives With DC-Link Shunt

This paper aims to reveal an offset jitter-like waveform error, which is usually present in all three-phase current signals reconstructed from dc-link current samples. This paper also presents a method for the cancellation of that error, which could be useful in low-cost shaft-sensorless drives. A combination of two samples' time displacement and the line current pulse-width modulation (PWM) ripple produces a distinctive shape of the reconstructed current error, which is offset jitter like, and is always at the current ripple level. This unusual waveform distortion is often masked by other jitters and noise sources and therefore is typically not given in the relevant literature. However, the distortion is difficult to filter out, and it may be harmful, particularly in applications with low rated motor current. The proposed waveform correction scheme uses the readily available motor states in shaft-sensorless drives and does not require major computational effort. Experimental results show that the scheme recovers the α-β current waveforms and, as a result, prevent the increase in the sixth harmonic ripple in the d-q currents, which is inherent to the PWM inverter-controlled drives. Consequently, drives with the dc shunt will neither have current signal offset problems nor the need for d-q current signal prefilters with order significantly higher than usual.