Miracle-dz/UniFAR-FTUs huggingface dataset:
Lung tissues in patients with systemic sclerosis have gene expression patterns unique to pulmonary fibrosis and pulmonary hypertension.

OBJECTIVE Pulmonary complications, including pulmonary fibrosis (PF) and pulmonary arterial hypertension (PAH), are the leading cause of mortality in patients with systemic sclerosis (SSc). The aim of this study was to compare the molecular fingerprint of lung tissue and matching primary fibroblasts from patients with SSc with that of lung tissue and fibroblasts from normal donors, patients with idiopathic pulmonary fibrosis (IPF), and patients with idiopathic pulmonary arterial hypertension (IPAH). METHODS Lung tissue samples were obtained from 33 patients with SSc who underwent lung transplantation. Tissues and cells from a subgroup of SSc patients with predominantly PF or PAH were compared to those from normal donors, patients with IPF, and patients with IPAH. Microarray data were analyzed using efficiency analysis for determination of the optimal data-processing methods. Real-time polymerase chain reaction and immunohistochemistry were used to confirm differential levels of messenger RNA and protein, respectively. RESULTS Consensus efficiency analysis identified 242 and 335 genes that were differentially expressed in lungs and primary fibroblasts, respectively. SSc-PF and IPF lungs shared enriched functional groups in genes implicated in fibrosis, insulin-like growth factor signaling, and caveolin-mediated endocytosis. Gene functional groups shared by SSc-PAH and IPAH lungs included those involved in antigen presentation, chemokine activity, and interleukin-17 signaling. CONCLUSION Using microarray analysis on carefully phenotyped SSc and comparator lung tissues, we demonstrated distinct molecular profiles in tissues and fibroblasts from patients with SSc-associated lung disease compared to idiopathic forms of lung disease. Unique molecular signatures were generated that are disease specific (SSc) and phenotype specific (PF versus PAH). These signatures provide new insights into the pathogenesis and potential therapeutic targets of SSc-related lung disease.
The National Trajectory Project of Individuals Found Not Criminally Responsible on Account of Mental Disorder in Canada. Part 3: Trajectories and Outcomes through the Forensic System

Objective: To examine the processing and Review Board (RB) disposition outcomes of people found not criminally responsible on account of mental disorder (NCRMD) across the 3 most populous provinces in Canada. Although the Criminal Code is federally legislated, criminal justice is administered by provinces and territories. It follows that a person with mental illness who comes into conflict with the law and subsequently comes under the management of a legally mandated RB may experience different trajectories across jurisdictions. Method: The National Trajectory Project examined 1800 men and women found NCRMD in British Columbia (n = 222), Quebec (n = 1094), and Ontario (n = 484) between May 2000 and April 2005, followed until December 2008. Results: We found significant interprovincial differences in the trajectories of people found NCRMD, including time detained in hospital and time under the supervision of an RB. The odds of being conditionally or absolutely discharged by the RB varied across provinces, even after number of past offences, diagnosis at verdict, and most severe index offence (all covariates decreased likelihood of discharge) were considered. Conclusions: Considerable discrepancies in the application of NCRMD legislation and the processing of NCRMD cases through the forensic system across the provinces suggests that fair and equitable treatment under the law could be enhanced by increased national integration and collaboration.
The Effects of Social Network Structure on Enterprise Systems Success: A Longitudinal Multilevel Analysis

The implementation of enterprise systems has yielded mixed and unpredictable outcomes in organizations. Although the focus of prior research has been on training and individual self-efficacy as important enablers, we examine the roles that the social network structures of employees, and the organizational units where they work, play in influencing the postimplementation success. Data were gathered across several units within a large organization: immediately after the implementation, six months after the implementation, and one year after the implementation. Social network analysis was used to understand the effects of network structures, and hierarchical linear modeling was used to capture the multilevel effects at unit and individual levels. At the unit level of analysis, we found that centralized structures inhibit implementation success. At the individual level of analysis, employees with high in-degree and betweenness centrality reported high task impact and information quality. We also found a cross-level effect such that central employees in centralized units reported implementation success. This suggests that individual-level success can occur even within a unit structure that is detrimental to unit-level success. Our research has significant implications for the implementation of enterprise systems in large organizations.
Probability densities of turbulent temperature fluctuations.

Starting from an assumption of universality in turbulence and building upon the work in Y. G. Sinai and V. Yakhot, we construct a closed-form expression for the probability density function of temperature fluctuations. This result is found to be in good correspondence to experimental data obtained at Chicago and Yale. By extending this method, we obtain a similar expression for the probability density function of temperature differences between two times. Again the result is checked to hold very well, except for very short time separations
Nurse-physician collaboration and satisfaction with the decision-making process in three critical care units.

OBJECTIVE To assess and compare levels of nurse-physician collaboration and satisfaction with the decision-making process as reported by critical care nurses, resident physicians (residents), and attending physicians (attendings) in making decisions to transfer individual patients out of the critical care unit, and to assess if satisfaction predicts nurse retention. DESIGN Longitudinal descriptive correlational study using self-reporting instruments. SETTINGS A university hospital's surgical ICU, a community teaching hospital's medical ICU, and a community hospital's mixed ICU. SUBJECTS Eighty-one nurses, 23 residents, and 37 attendings from the surgical ICU; 44 nurses and 51 residents from the medical ICU; 25 nurses and 45 attendings from the community hospital's ICU, reporting on the transfers of 473, 465, and 494 patients, respectively. MAIN OUTCOME MEASURES Healthcare providers' reported levels of collaboration and satisfaction with the decision-making process, the correlations between collaboration and satisfaction, and nurse retention. RESULTS Nurses and physicians within sites (except attendings from the surgical ICU) reported similarly moderate amounts of collaboration, but nurses reported less satisfaction with decision making than did physicians in all sites. Collaboration was related to satisfaction with decision making for all providers, but more strongly for nurses. The strength of the relationship for nurses was similar in all sites. Nurses' satisfaction with decision making did not predict their retention. CONCLUSIONS Collaboration between nurses and physicians is a more important component of satisfaction with decision making for nurses than for physicians. Any interventions to change the amount of collaboration in practice must take account of this difference.
Medical officers in Acute Care Settings: Their Views on Medically Assisted Hydration at the end of Life

This study explored the perceptions of doctors in acute care settings regarding the use of medically assisted hydration (MAH) in end-of-life care. The use of MAH at the end of life is controversial, and practice varies across health care settings. A qualitative study using discourse analysis was carried out. Eight medical practitioners in the acute care setting were interviewed individually. MAH has been associated with care, comfort, and standard medical intervention to save lives. Medical officers have some concerns about the benefits or adverse effects of MAH at the end of life. In acute care settings, it can be difficult to recognize and diagnose dying. Often, family discussions regarding end-of-life care do not occur due to pursuit of cure and, therefore, continuation of futile and burdensome treatment such as MAH can occur in the last few days of life.
Effect of oxygen transfer on lipase production by Acinetobacter radioresistens.

The influence of oxygen on alkaline lipase production by Acinetobacter radioresistens was studied under two operating modes: controlled dissolved oxygen (DO) concentration and controlled aeration rate. Compared with cell growth, the lipase production depended more extensively on oxygen. The intrinsic factor determining cell growth and lipase production was oxygen transfer rate (OTR) rather than DO concentration. Improvements in OTR, either by aeration or agitation, resulted in an increase in lipase yield and/or a reduction in fermentation time. The formation of A. radioresistens lipase could be described by a mixed-growth-associated model, and the enzyme was mainly a growth-associated product. The overall productivity for the lipase, which depended more strongly on agitation than aeration, could be related with kLa. DO concentration could not be employed in this correlation, though it has been useful as a criterion for ensuring no oxygen limitation in an aerobic fermentation.
Gastro-oesophageal incompetence in children, with special reference to minor degrees of partial thoracic stomach.

It is becoming recognised that weakness of the valve mechanism between oesophagus and stomach is a not infrequent cause of vomiting in infancy and early childhood (1, 2). This gastro-oesophageal incompetence allows abnormal reflux of stomach contents into the gullet, a process facilitated by the horizontal posture and fluid diet of infancy. In 1947, Neuhauser and Berenberg described in babies the condition of cardio-oesophageal relaxation or “chalasia,” in which the cardia is normally situated but wide and patulous, permitting easy reflux (3–5). More frequent than this condition, in our experience with children, is the so-called “short oesophagus,” with a small proportion of the stomach situated above the diaphragm. At The Children's Hospital in Birmingham (England), the annual incidence of hypertrophic pyloric stenosis is about 90 cases. In one year we see about 18 infants under twelve months of age, as well as a number in the older age groups, in whom vomiting is associated with a minor degree of partia.
Movement Towards Coherence in the Psychotherapy of Schizophrenia: A Method for Assessing Narrative Transformation

*Day Hospital, Roudebush VA Medical Center; †Department of Psychiatry, Indiana University School of Medicine; ‡Department of Psychology, University of Indianapolis; and §Department of Psychology, Indiana University–Purdue University Indianapolis, Indianapolis, Indiana. Reprints: Dr. Lysaker. Day Hospital 116H, Roudebush VA Medical Center, 1481 West 10th St., Indianapolis, IN 46202. Copyright © 2003 by Lippincott Williams & Wilkins DOI: 10.1097/01.nmd. 0000082182.77891. 89
Intraindividual variability of the modified Schwartz and novel CKiD GFR equations in pediatric renal transplant patients

Tsampalieros A, Lepage N, Feber J. Intraindividual variability of the modified Schwartz and novel CKiD GFR equations in pediatric renal transplant patients. Pediatr Transplantation 2011: 15: 760–765. © 2011 John Wiley & Sons A/S.
The development of emotion regulation and dysregulation: a clinical perspective.

Clinical conceptualizations of emotion that stress its disruptive influences and functional models of emotion that emphasize its adaptive aspects can be integrated into a developmental psychopathology framework. Under certain conditions, emotion regulation may develop dysregulatory aspects that can become a characteristic of an individual's coping style. This style may then jeopardize or impair functioning and become associated with symptomatic, disordered functioning. Emotional development provides a critical vantage point from which to study the development of symptomatology and psychopathology, particularly given the prevalence of emotional symptoms in various forms of psychopathology. Dimensions of emotionality that can be used to characterize dysregulation include access to the range of emotions, flexible modulation of intensity, duration, and transitions between emotions, acquisition and use of cultural display rules, and the ability to reflect on the complexity and value of one's own emotions in a self-supporting manner. Developmental psychopathology provides a framework within which to examine how emotions are regulatory, how their regulation changes over time, and under what conditions an adaptive emotion process can develop into a pattern of dysregulation that then becomes, or sustains, some symptoms of mental disorders. Such research requires samples that include children with and without risk or presence of particular mental health problems, paradigms that allow the examination of dimensions of emotionality in context and provide multiple assessments that include observations of children's reactions beyond what they themselves can report, and analyses that extend beyond simple global aggregates such as positive and negative emotion. We believe that it is particularly important to study children and their families in situations that challenge their emotional adaptation. The developmental tasks of emotional life evolve in exchanges between the child and the world of events and relationships. The emotional conditions of early childhood appear to be very important in optimizing or interfering with how the child's emotionality regulates his or her interpersonal and intrapsychic functioning and how the child learns to regulate emotion. The experiences that accrue around emotional events influence the stable aspects of the developing personality and become trait-like aspects of the person (Malatesta & Wilson, 1988). Dysregulation occurs when an emotional reaction loses breadth and flexibility. If a dysregulatory pattern becomes stabilized and part of the emotional repertoire, it is likely that this pattern is a symptom and supports other symptoms. When development and adaptation are compromised, the dysregulation has evolved into a form of psychopathology. The line between normative variations and clinical conditions is not clearly drawn. (ABSTRACT TRUNCATED AT 400 WORDS)
Global coherence in younger and older adults: Influence of cognitive processes and discourse type

ABSTRACT The purpose of the present research was to examine the influence of cognitive processes on discourse global coherence ability measured across different discourse tasks and collected from younger (n = 40; 20–39 years) and older (n = 40; 70–87 years) cognitively healthy adults. Study participants produced oral language samples in response to five commonly used discourse elicitation tasks and they were analyzed for maintenance of global coherence. Participants also completed memory and attention measures. Group differences on the global coherence scale were found for only one type of discourse—recounts. Across discourse elicitation tasks the lowest global coherence scores were found for recounts compared to the other discourse elicitation tasks. The influence of cognitive processes on maintenance of global coherence differed for the two age groups. For the younger group, there were no observed significant relationships. For the older group, cognitive measures were related to global coherence of stories and procedures.
Effects of combined electrostimulation and plyometric training on vertical jump and speed tests

Benito-Martinez E, Lara-Sanchez AJ, Berdejo-del-Fresno D, Martinez-Lopez EJ. Effects of combined electrostimulation and plyometric training on vertical jump and speed tests. J. Hum. Sport Exerc. Vol. 6, No. 4, pp. 603-615, 2011. The aim of this study was to determine the performance evolution of a group of athletes after 8 weeks of training that combined electrostimulation (NM ES) and plyometrics (PT). 78 medium level sprinter athletes participated, 40 women and 38 men (age, 15.9±1.4 years old, body mass index, 20.5±1.68 kg/m 2 ; weight 58.53±8.05 kg; height, 1.68±0.07 m). The sample was randomized into four groups [Control (PT only), NM ES + PT, PT + NM ES, and Simultaneous (plyometric jumps were performed through the passage of current). Improvements were obtained in the Abalakov jump of 3.57% (p<0.01), 13.51% (p<0.001), 1.23% (p<0.01), and 0.77%, and in the sprint of 0.45%, 3.87% (p<0.05), 4.56% (p<0.01) and 7.26% p<0.001 for the control group, NM ES + PT group, PT + NM ES group, and Simultaneous group, respectively. It was concluded that a) improvement in vertical jump requires the application of the NM ES prior to PT; b) the sprinter athlete must combine the workout simultaneously or apply the ES after the PT training; and c) in sportspeople that require improvement in both the vertical jump and speed tests (e.g. basketball) the simultaneous method is not recommended, the order of application of NM ES and PT being non-determinant. Finally, the time needed to obtain significant improvement in strength training through a combination of NM ES and PT is substantially lower (15 days) than the time needed to improve speed (30 days). Key words: ELECTROSTIMULATION, PLYOMETRICS, MUSCLE STRENGTH, ABALAKOV JUMP, SPEED 30 M LAUNCHED.
UCHL‐1 is not a Parkinson's disease susceptibility gene

The UCHL‐1 gene is widely cited as a susceptibility factor for sporadic Parkinson's disease (PD). The strongest evidence comes from a meta‐analysis of small studies that reported the S18Y polymorphism as protective against PD, after pooling studies of white and Asian subjects. Here, we present data that challenge this association.
Carbohydrate Feeding before Exercise: Effect of Glycemic Index

Low glycemic index (GI) foods may confer an advantage when eaten before prolonged strenuous exercise by providing a slow-release source of glucose to the blood without an accompanying insulin surge. To test this hypothesis, eight trained cyclists pedalled to exhaustion one hour after ingestion of equal carbohydrate portions of four test meals: lentils, a low GI food (LGI); potato, a high GI food (HGI), and glucose and water. Plasma glucose and insulin levels were lower after LGI than after HGI from 30 to 60 min after ingestion (p less than 0.05). Plasma free fatty acid (FFA) levels were highest after water (p less than 0.05) followed by LGI and then glucose and HGI. From 45 to 60 min after ingestion, plasma lactate was higher in the HGI trial than in the LGI trial (p less than 0.05) and remained higher throughout the period of exercise. The rank order from lowest to highest for total carbohydrate oxidation during exercise was water, lentils, glucose and potato. Endurance time was 20 min longer after LGI than after HGI (p less than 0.05). These findings suggest that a low GI pre-game meal may prolong endurance during strenuous exercise by inducing less post-prandial hyperglycemia and hyperinsulinemia, lower levels of plasma lactate before and during exercise, and by maintaining plasma glucose and FFA at higher levels during critical periods of exercise.
A Male Head Found at Dabar Kot

The purpose of this note is to draw attention to a small stone sculpture from Dabar Kot, representing a male head, five centimetres high, first published by Sir Aurel Stein (n.1). From the photographs (PL. XL) we can see that the eyebrows are marked by a thick continuous notched groove, the large eyeholes da not contain eyeballs, the k g e projecting nose is broken off far the @eater part and that the small mouth consists only of two slits. A peculiarity is the rendering of the ears by fiat, oval protuberances, which show no further mark of detaiL On the neck, the small round holes, originally inhid, must suggest a string of beads. Adornment with necklaces, bracelets or anklets OCCUFS repeatedly on the ‘Mother goddess’ figurines in the cultures of the peasant communities of Baluchistan, as well as in the Harappan Civilization. From Sir Aurel Steinas description it is not clear what the exact circumstances of this find were. Because, however, he makes no mention of earlier material found in the same trench-indeed apparently none has been found in situ--but only of objects from the Harappan Civilization and possibly later periods, it seems to me unlikely that this head could be regarded as pae-Harappan. As there are no indications to place it in a later period, and in view of the foregoing considerations, it seems more probable that this head comes from the Harappan layer found at Dabar Kot which indeed was once a trading post for that civilization. On examination of the photographs it also seems that this head, although found in Northern Baluchistan, shows some characteristics of the sculpture from Sumer and the river Diyala area in the EarIy Dynastic Period. The rendering of the ears by fiat, oval protuberances has no parallels in the Harappan Civilization, but can be paralleled in a head from the Nintu Temple VI of Khafajah, dated by*H. Frankfort in the Early Dynastic I1 Period (n. 2). This indication, together with the clumsy workmanship of the piece, could perhaps suggest an Early Dynastic I1 dating, although the clumsy workmanship could also be a sign it is a local imitation made after a Mesopotamian model. E. C. L. DURING CASPERS PLATE XL
The Use of Cigarette Package Inserts to Supplement Pictorial Health Warnings: An Evaluation of the Canadian Policy.

BACKGROUND Canada is the first country in the world to require cigarette manufacturers to enclose package inserts to supplement the exterior pictorial health warning label (HWL). In June 2012, Canada implemented new HWL package inserts that include cessation tips accompanied by a pictorial image. This study aims to assess the extent to which adult smokers report reading the newly mandated HWL inserts and to see whether reading them is associated with making a quit attempt. METHODS Data were analyzed from an online consumer panel of Canadian adult smokers, aged 18-64 years. Five waves of data were collected between September 2012 and January 2014, separated by 4-months intervals (n = 1,000 at each wave). Logistic generalized estimating equation (GEE) models were estimated to assess correlates of reading inserts and whether doing so is associated with making a quit attempt by the subsequent wave. RESULTS At each wave, between 26% and 31% of the sample reported having read HWL package inserts at least once in the prior month. Smokers who read them were more likely to be younger, female, have higher income, intend to quit, have recently tried to quit, and thought more frequently about health risks because of warning labels. In models that adjusted for these and other potential confounders, smokers who read the inserts a few times or more in the past month were more likely to make a quit attempt at the subsequent wave compared to smokers who did not read the inserts. CONCLUSIONS HWL package inserts with cessation-related tips and messages appear to increase quit attempts made by smokers.