Miracle-dz/UniFAR-FTUs huggingface dataset:
From industry 4.0 to Society 5.0: challenges for sustainable competitiveness of Russian industry

The globalization and digitalization of the world economy keep up to date the problems of attaining sustainable competitiveness for the Russian industrial enterprises. The purpose of investigation is to study the ways of solving these problems on the basis of integrated approach combining the key provisions of concepts of competitiveness of enterprises, sustainable development and information society. The authors have given consideration to interrelation of digitalization objectives and goals of sustainable development reflected in the concepts of Industry 4.0, Society 5.0. The problems of adaptation of the Russian industry to the changes in process and state support to these processes have been revealed. A necessity of shaping a comprehensive methodology under conditions of global digitalization of economy and society on the basis of investigating the genesis of theory and methodology of ensuring competitiveness and sustainable development has been substantiated.
Limited-Sampling Strategies for Therapeutic Drug Monitoring of Moxifloxacin in Patients With Tuberculosis

Background: Moxifloxacin (MFX) is a potent drug for multidrug resistant tuberculosis(TB) treatment and is also useful if first-line agents are not tolerated. Therapeutic drug monitoring may help to prevent treatment failure. Obtaining a full concentration-time curve of MFX for therapeutic drug monitoring is not feasible in most settings. Developing a limited-sampling strategy based on population pharmacokinetics (PK) may help to overcome this problem. Methods: Steady-state plasma concentrations after the administration of 400 mg of MFX once daily were determined in 21 patients with TB, using a validated liquid chromatography-tandem mass spectrometry method. A one-compartment population model was generated and crossvalidated. Monte Carlo data simulation (n = 1000) was used to calculate limited-sampling strategies. The correlation between predicted MFX AUC0-24h (area under the concentration-time curve 0 to 24 hours) and observed AUC0-24h was investigated by Bland-Altman analysis. Finally, the predictive performance of the final model was tested prospectively using MFX profiles from patients with TB receiving 400, 600, or 800 mg once daily. Results: Median minimum inhibitory concentration of Mycobacterium tuberculosis isolates was 0.25 mg/L (interquartile range: 0.25-0.5 mg/L). The geometric mean AUC0-24h was 24.5 mg·h/L (range: 8.5-72.2 mg·h/L), which resulted in a geometric mean AUC0-24h/minimum inhibitory concentration ratio of 72 (range: 21-321). PK analysis, based on PK profiles of 400 mg of MFX once daily, resulted in a crossvalidated population PK model with the following parameters: apparent clearance (Cl) 18.5 ± 8.6 L/h per 1.85 m2, Vd 3.0 ± 0.7 L/kg corrected lean body mass, Ka 1.15 ± 1.16 h−1, and F was fixed at 1. After the Monte Carlo simulation, the best predicting strategy for MFX AUC0-24h for practical use was based on MFX concentrations 4 and 14 hours postdosing (r2 = 0.90, prediction bias = −1.5%, and root mean square error = 15%). Conclusions: MFX AUC0-24h in patients with TB can be predicted with acceptable accuracy for clinical management, using limited sampling. AUC0-24h prediction based on 2 samples, 4 and 14 hours postdose, can be used to individualize treatment.
Proportional-integrative controller design of Pneumatic system using particle swarm optimization

Pneumatic systems are well known for their advantages, simplicity and can be applied in various industrial applications. This paper presents a comparative study of tuning methods on Proportional-Integral (PI) controller for position control performance both in simulation and in real system. A PI controller designed by optimization with the Particle Swarm Optimization (PSO) algorithm is proposed and its output is compared with the Ziegler-Nichols (Z-N) formula and manual (trial and error) results. Performance assessment of the tuned controllers was performed in MATLAB Simulink. It was observed that the controller designed using PSO gives better results and performance compared to the Z-N formula and manual tuning in simulation and real-time.
Mobile Plus: Multi-device Mobile Platform for Cross-device Functionality Sharing

In recent years, the explosion of diverse smart devices such as mobile phones, TVs, watches, and even cars, has completely changed our lives. We communicate with friends through social network services (SNSs) whenever we want, buy stuff without visiting shops, and enjoy multimedia wherever we are, thanks to these devices. However, these smart devices cannot simply interact with each other even though they are right next to each other. For example, when you want to read a PDF stored on a smartphone on a larger TV screen, you need to do complicated work or plug in a bunch of cables. In this paper, we introduce M+, an extension of Android that supports cross-device functionality sharing in a transparent manner. As a platform-level solution, M+ enables unmodified Android applications to utilize not only application functionalities but also system functionalities across devices, as if they were to utilize them inside the same device. In addition to secure connection setup, M+ also allows performing of permission checks for remote applications in the same way as for local. Our experimental results show that M+ enables transparent cross-device sharing for various functionalities and achieves performance close to that of within-device sharing unless a large amount of data is transferred.
Research on the Influence of Corporate Governance Structure on the Performance of Nepal Commercial Banks

The current researches portray the corporate governance’s variables on non-performing loan of commercial bank in Nepal. The total assists of the bank depend on the dependent variables of are non-performing loan and nonperforming loan to total assets while the independent variables includes i.e. board size, independent directors, audit committee member, foreign ownership, domestic ownership, CEO duality, bank age, female director, board meeting and bank size. So the study conducted in current research is based on the data obtained from eighteen commercial banks in Nepal dated: 2010/2011to 2015/2016, leading to a total of 108 observations. Some of the data were obtained from websites and annual reports of the Nepalese Banks. The data were analysed through regression model to examine the importance of corporate governance variables on non-performing loan. Some of the result has positive correlation with the ratio of non-performance loan which shows that diversified the board, director of board, audit committee higher will be the ratio of nonperforming loan and vice versa, while the result has negative impact on the presence of foreign ownership which are otherwise explain the presence of foreign of ownership would reduce the bank proficiency. Furthermore the presence of domestic ownership has increased the efficiency of the corporate banking sectors. The presence of dual CEO is also negative relation with the performance of the bank. Similarly the age of bank, presence of female director, number of board meeting and bank size has positive relation with the said topic. Citation: Gupta AK, Wei GX (2018) Research on the Influence of Corporate Governance Structure on the Performance of Nepal Commercial Banks. J Glob Econ 6: 316. doi: 10.4172/2375-4389.1000316
The value of top-down communication for organizational performance

We design a laboratory experiment to identify causal performance effects of top-down communication between managers and their subordinates. Our focus lies on communication that resolves uncertainty about the work environment but does not provide task-specific knowledge. Recent articles in the business press report a lack of such communication in real-world organizations and associate it with reduced organiza- tional performance. Our results confirm this observation. We find that top-down communication is a profitable way for managers to increase employee performance in the presence of uncertainty. Specifically, we show that non-communication is the worst option for managers. However, 50 percent of our experimental managers use top-down communication too restrictively. Overall, managers forego 30 percent of their potential profits through non-communication. We show that organizations can overcome this problem by adopting automated information procedures, which are equally effective.
Acetylation of PML Is Involved in Histone Deacetylase Inhibitor-mediated Apoptosis*

PML is a potent tumor suppressor and proapoptotic factor and is functionally regulated by post-translational modifications such as phosphorylation, sumoylation, and ubiquitination. Histone deacetylase (HDAC) inhibitors are a promising class of targeted anticancer agents and induce apoptosis in cancer cells by largely unknown mechanisms. We report here a novel post-transcriptional modification, acetylation, of PML. PML exists as an acetylated protein in HeLa cells, and its acetylation is enhanced by coexpression of p300 or treatment with a HDAC inhibitor, trichostatin A. Increased PML acetylation is associated with increased sumoylation of PML in vitro and in vivo. PML is involved in trichostatin A-induced apoptosis and PML with an acetylation-defective mutation shows an inability to mediate apoptosis, suggesting the importance of PML acetylation. Our work provides new insights into PML regulation by post-translational modification and new information about the therapeutic mechanism of HDAC inhibitors.
Fine‐needle aspiration of abdominal fat pad for amyloid detection: A clinically useful test?

Fine‐needle aspiration of abdominal fat pad (FNAFP) is commonly employed for the diagnosis of systemic amyloidosis, a disease with highly variable clinical manifestations, often presenting difficult patient management problems. We evaluated the role of FNAFP particularly in reference to its clinical usefulness. Pathology reports and clinical histories of 91 consecutive cases of FNAFP with Congo red (CR) staining at The Johns Hopkins Hospital (1999–2000) were reviewed. Major emphases were assessment of the clinical utility of the test, correlation with concurrent or subsequent biopsies, and treatment strategies. The primary indications for FNAFP were monoclonal gammopathy (34%), cardiomyopathy (22%), renal insufficiency (20%), neuropathy (8%), plasma cell dyscrasia (6%), and other conditions (10%). Of the 91 patients who underwent FNAFP, the results were as follows; 20 cases (22%) positive; 62 cases (68%) negative; eight cases (9%) insufficient for diagnosis; and one case (1%) equivocal. Of the 20 positive cases, follow‐up biopsies were performed on 11 cases, of which six were positive and five were negative for amyloid by CR. Of the 62 negative cases, follow‐up biopsies were performed on 19 cases, 14 of which were negative and five positive for amyloid by CR. A follow‐up biopsy on the single equivocal case was positive for amyloid by CR. Twenty‐one patients positive for amyloid, based on initial or follow‐up biopsies, were managed symptomatically without any specific treatment for amyloidosis. One patient, who was specifically treated for amyloidosis by melphalan and dexamethasone, died 1 wk after therapy. Three patients with multiple myeloma and amyloidosis underwent chemotherapy. We conclude that primary clinical indications for FNAFP for amyloidosis are highly variable. An FNAFP result is often not considered clinically conclusive and is followed by further invasive procedures to detect amyloid (55% of our positive and 31% of our negative FNAFP cases were rebiopsied). The estimated sensitivity and specificity of FNAFP were 75% and 92%, respectively. Overall, the reliance on the results of FNAFP depended on the degree of clinical suspicion of the treating physician. Although in the majority of cases diagnosis of amyloidosis did not alter the treatment strategies, a conclusive positive result helped in ruling out other underlying conditions as the cause of patients' symptoms. Diagn. Cytopathol. 2004;30:178–181. © 2004 Wiley‐Liss, Inc.
Epistatic Suppression of Systemic Lupus Erythematosus: Fine Mapping of Sles1 to Less Than 1 Mb1

Sle is a susceptibility locus for systemic autoimmunity derived from the lupus-prone NZM2410 mouse. The New Zealand White-derived suppressive modifier Sles1 was identified as a specific modifier of Sle1 and prevents the development of IgG anti-chromatin autoantibodies mediated by Sle1 on the C57BL/6 (B6) background. Fine mapping of Sles1 with truncated congenic intervals localizes it to a ∼956-kb segment of mouse chromosome 17. Sles1 completely abrogates the development of activated T and B cell populations in B6.Sle1. Despite this suppression of the Sle1-mediated cell surface activation phenotypes, B6.Sle1 Sles1 splenic B cells still exhibit intrinsic ERK phosphorylation. Classic genetic complementation tests using the nonautoimmmune 129/SvJ mouse suggests that this strain possesses a Sles1 allele complementary to that of New Zealand White, as evidenced by the lack of glomerulonephritis, splenomegaly, and antinuclear autoantibody production seen in (129 × B6.Sle1 Sles1)F1s. These findings localize and characterize the suppressive properties of Sles1 and implicate 129 as a useful strain for aiding in the identification of this elusive epistatic modifier gene.
Faktor-Faktor Yang Mempengaruhi Praktik Perataan Laba (Income Smoothing) Studi empiris pada perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia (BEI) tahun 2011-2014

The purpose of this research is to examine the influence of company size, financial leverage, net profit margin, operatig profit margin, return on assets, and company’s development toward the practice of income smoothing. The sample used in this study at 39 manufacturing companies listed on the Indonesian Stock Exchange beginning in 2011 to 2014 were obtained by purposive sampling method. Independent variable that examined in this research are company size, financial leverage, net profit margin, operating profit margin, return on assets, and company’s development. Eckel index was used to determine firms who did income smoothing and didn’t do income smoothing. The hypothesis was examined using binary logistic regression. According to hypothesis test, the result of this research is company size have negative and significant influence toward the practice of income smoothing. Financial leverage which proxied by DER (dept to total equity) have positive and significant influence toward the practice of income smoothing. ROA (return on assets) and net profit margin have not significant influence toward the practice of income smoothing. company’s development which proxid by EPS (earning per share)and operating profit margin and have not significant influence toward the practice of income smoothing.
Metformin-associated lactic acidosis: A prognostic and therapeutic study*

Objectives: Metformin-associated lactic acidosis is a rare and serious complication of biguanide treatment. It usually occurs when a precipitating disease induces an acute renal failure and an incidental overdose. Voluntary intoxication is rare. Bicarbonate hemodialysis (HD) is recommended to decrease metformin levels and correct acidosis but its optimal duration has not been determined. This study was designed to document the characteristics and prognostic factors of intentional and incidental metformin overdose and to determine the optimal duration of HD. Design: Ten years retrospective analysis of patients admitted in intensive care unit for metformin-associated lactic acidosis. Setting: Two intensive care units (50 beds) in a university hospital. Measurements and Main Results: Clinical and biological characteristics, organ failures, and sequential metformin levels during HD were recorded. Forty-two patients were included (13 voluntary intoxications and 29 incidental overdoses); 74% of patients were in acute renal failure and needed HD. No death was observed in intentional overdose patients compared with 48.3% mortality in incidental overdose patients. The factors significantly associated with mortality were logistic organ dysfunction system score, pH, plasma lactate, and prothrombin activity. By multivariate analysis, a prothrombin activity <50% was the only independent predictive factor of mortality (relative risk: 59.8; confidence limits: 6.3–568; p < 0.0001). Sequential measurements of metformin levels during HD were consistent with a bicompartmental elimination pattern. A cumulative HD duration of 15 hours was associated with the return of metformin level to the therapeutic normal range. Conclusions: In our study, the outcome of MALA was uniformly favorable after intentional metformin overdose. The vital prognosis was mainly influenced by the occurrence of multiple organ dysfunctions, the best predictive factor of death being an acute liver dysfunction as assessed by PT activity. Prolonged HD was needed to correct metformin overdose.
Consumption experience: past, present and future

Purpose The purpose of this paper is to propose both a retrospective and a prospective look at one of the most powerful concepts in marketing research: consumption experience. Design/methodology/approach A historical review of the development of the concept of consumption experience is conducted from its introduction 35 years ago by Holbrook and Hirschman’s (1982) seminal paper to the most recent advances, including the articles selected for this special issue. Findings First, the authors show that the introduction of the concept of consumer experience was a major (r)evolution on the theoretical, methodological and managerial levels. Second, the authors examine the theoretical risks associated with a biased conceptualization of the consumption experience. Third, the authors highlight future avenues for research on the consumption experience from both macro- (“zoom-out”) and micro-analytic (“zoom-in”) perspectives. Originality/value This paper offers a comprehensive view on one of the most disruptive concepts in marketing theory.
The Relationship of Shoulder Pain Intensity to Quality of Life, Physical Activity, and Community Participation in Persons With Paraplegia

Abstract Background/Objective: For persons with spinal cord injury (SCI), severe bodily pain is related to a lower quality of life. However, the effect of pain from a specific body region on quality of life has yet to be determined. The shoulder joint is a common site of pain among persons with SCI. Therefore, our purpose was to identify the relationship of self-reported shoulder pain with quality of life, physical activity, and community activities in persons with paraplegia resulting from SCI. Methods: Eighty participants with shoulder pain who propel a manual wheelchair (mean age: 44.7 years; mean duration of injury: 20 years; injury level T1-L2) completed the following questionnaires: Wheelchair User's Shoulder Pain Index, Subjective Quality of Life Scale, Physical Activity Scale for Individuals with Physical Disabilities, and Community Activities Checklist. Correlations between shoulder pain scores and quality of life, physical activity, and community activities were determined using Spearman's rho test. Results: Shoulder pain intensity was inversely related to subjective quality of life (rs=-0.35; P=0.002) and physical activity (rs =-0.42; P < 0.001). Shoulder pain intensity was not related to involvement in community activities (rs = -0.07; P= 0.526). Conclusions: Persons with SCI who reported lower subjective quality of life and physical activity scores experienced significantly higher levels of shoulder pain. However, shoulder pain intensity did not relate to involvement in general community activities. Attention to and interventions for shoulder pain in persons with SCI may improve their overall quality of life and physical activity.
Longitudinal associations between social connections and subjective wellbeing in the English Longitudinal Study of Ageing

Objective: The role of social relationships in determining well-being may be particularly salient in ageing populations. There is only limited longitudinal research examining the relationship between different dimensions of social relationships and change in well-being over time. The present analysis explores the association between isolation, loneliness and two measures of subjective well-being over six years using data from the English Longitudinal Study of Ageing. Design: Measures of social relationships were obtained at baseline and associations with well-being over the following six years were analysed using mixed models. Main outcome measures: Hedonic and evaluative well-being assessed every two years over the six-year period. Results: Levels of well-being showed a U-shaped relationship with time. At baseline, higher isolation and loneliness were associated with lower levels of hedonic and evaluative well-being. Individuals with high levels of isolation and loneliness initially showed a smaller decrease in evaluative well-being. The subsequent rise in well-being was, however, also diminished in this group. In contrast, loneliness was not associated with rate of change in hedonic well-being, while high levels of isolation were associated with a sustained decrease in hedonic well-being. Conclusion: Social isolation and loneliness show different associations with changes in evaluative and hedonic well-being over time.
Dual-band printed inverted-F antenna for DCS, 2.4GHz WLAN applications

A new dual band printed inverted-F antenna (PIFA) for the 1.8 GHz digital communication system (DCS) and 2.4 GHz wireless local area network (WLAN) application is presented. The proposed antenna is based on a conventional PIFA, where the shorting strip is modified into a meandering shape such that the antenna can have a double resonance. The antenna finds an impedance bandwidth of 10.85% and 3.61% for SlK-10 dB at 1.8 GHz and 2.45 GHz, respectively. The maximum antenna gains are 2.83 dBi and 3.31 dBi correspondingly.
Impact of functional/cognitive and emotional advertisements on image and repurchase intention

ABSTRACT In this study, we attempted to explore the role of chain steakhouse image (functional, symbolic, and experiential), pleasure, arousal, and brand satisfaction in building customer repurchase intention and to uncover the moderating impact of functional/cognitive and emotional advertisements (ads). A field survey was conducted for data collection. A quantitative approach was employed to analyze the data. Findings from the structural analysis showed that image, emotions, and satisfaction played a significant role in generating intention, both pleasure and satisfaction acted as mediators, and hypothesized associations were mostly supported. Moreover, the relationships among functional image, pleasure, and brand satisfaction within the proposed theoretical framework were significantly moderated by functional/cognitive and emotional ads. Implications for researchers and practitioners are discussed. Current research provides chain steakhouse management a better understanding of the underlying complicated mechanism of customers’ repurchase decision generation process.