Miracle-dz/UniFAR-FTUs huggingface dataset:
The KMOS Deep Survey (KDS) - I. Dynamical measurements of typical star-forming galaxies at z ≃ 3.5

We present dynamical measurements from the KMOS (K-band Multi-Object Spectrograph) Deep Survey (KDS), which is comprised of 77 typical star-forming galaxies at z $\simeq$ 3.5 in the mass range 9.0 1), with the sample average V$_{C}$/{\sigma}$_{int}$ value much smaller than at lower redshift. After carefully selecting comparable star-forming samples at multiple epochs, we find that the rotation-dominated fraction evolves with redshift with a z$^{-0.2}$ dependence. The rotation-dominated KDS galaxies show no clear offset from the local rotation velocity-stellar mass (i.e. V$_{C}$-M$_{\star}$) relation, although a smaller fraction of the galaxies are on the relation due to the increase in the dispersion-dominated fraction. These observations are consistent with a simple equilibrium model picture, in which random motions are boosted in high redshift galaxies by a combination of the increasing gas fractions, accretion efficiency, specific star-formation rate and stellar feedback and which may provide significant pressure support against gravity on the galactic disk scale.
Plagioclase replacement textures in partially eclogitised gabbros from the Sanddal ma ® c-ultrama ® c complex , Greenland

The Sanddal ma®c-ultrama®c complex (SMUK) is a cluster of variably eclogitised ma®c and ultrama®c bodies that comprise the westernmost known eclogite facies locality in the North-East Greenland eclogite province (NEGEP). Although there are no true eclogites in the SMUK, we interpret three distinct textural types of plagioclase replacement to record sequential stages in adjustment of SMUK olivine gabbronorites to eclogite facies conditions. The earliest stage, in which plagioclase was replaced by omphacite/ spinel symplectite before nucleation of garnet (Type 1A & 1B) has not previously been described. Documentation of this texture provides clear evidence that, at least in some cases, garnet nucleation is delayed relative to nucleation of omphacite and is a rate-limiting step for eclogitisation. Type 1C domains were produced by scattered nucleation of garnet in the same sample. In Type 2 domains, plagioclase was replaced by a layered corona with an outer layer of garnet, an inner layer of omphacite and an interior of inclusion-rich plagioclase. In Type 3 domains, the omphacite layer was overgrown by the garnet rim, and omphacite is preserved only as inclusions in garnet. In more coarse grained leucogabbros, recrystallization was more complete, plagioclase replacement textures were less localised, and could not be divided into distinct stages. Plagioclase replacement in SMUK samples was not isochemical, and required diffusion of at least Mg and Fe from replacement of ma®c phases in the surroundings. Strong compositional gradients in garnet re ̄ect disequilibrium and were controlled by the different diffusion rates of Mg/Fe and Ca, different local chemical environments, and progress of the plagioclase breakdown reaction. The presence of small amounts of hydrous minerals (amphibole, phlogopite and clinozoisite) in local equilibrium in plagioclase domains of most SMUK samples indicates that a small amount of H2O was present during high pressure metamorphism.
Comparative Study of Professionalism of Future Medical Doctors Between Malaysia and Bangladesh

Md. Zakirul Islam, Abdus Salam, Asadul Mazid Helali, Zaida Rahman, Wan Putri Elena Wan Dali, Salwani Ismail, Nor Iza A Rahman, Mainul Haque Department of Pharmacology & Therapeutics, Eastern Medical College, Comilla, Bangladesh. Department of Medical Education, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. 3 Department of Pharmacology & Therapeutics, Gonoshasthya Samajvittik Medical College & Hospital, Savar, Dhaka, Bangladesh. 4 Department of Pharmacology & Therapeutics, Enam Medical College, Savar, Dhaka, Bangladesh. 5 Faculty of Medicine and Health Sciences (FPSK), Universiti Sultan Zainal Abidin (UniSZA), Terengganu, Malaysia.
Measurement of Physician Performance by Standardized Patients: Refining Techniques for Undetected Entry in Physicians' Offices

The article describes the development of methods to use live simulated patients for assessment of quality of care of primary physicians. Methods used to train patients and achieve undetected entry into physicians' practices are described. The study demonstrated that patients can be entered into practices with a low rate of detection (13%) and that they are able to recall the details of the encounter with a high degree of reliability.
The Effect of Advanced Oxidation Processes on Leachate Biodegradation in Recycling Lysimeters

Landfill processes were simulated in laboratory-scale bioreactors - lysimeters. The changes in leachate characteristics as well as the influence of advanced oxidation processes (AOPs) on the processes taking place in the sanitary landfill were investigated. Lysimeters were filled with material simulating municipal waste in the city of Lodz, Poland. Compost in the amount of 30% w/w and the methanogens inoculum were added in order to enhance development of a methanogenic phase. The leachate produced in lysimeters was recirculated. In order to investigate the influence of AOPs implementation on processes taking place in landfills two runs in lysimeters were performed, each lasting about 250 days. The leachate composition and biogas composition and production changes showed trends that confirmed that the bench-scale lysimeters appeared suitable to simulate processes taking place in the landfill. The application of AOPs to the leachate recirculated into the lysimeters did not bring about unequivocally positive effects. The ozonation of the leachate, implemented at the beginning of the methanogenic phase, caused slight acceleration (about 2 weeks) of the bio-degradation, whereas employment of H2O2/UV led to the inhibition of anaerobic processes.
Long-term prognosis of fulminant myocarditis rescued by percutaneous cardiopulmonary support device.

BACKGROUND The long-term prognosis and cardiac function of fulminant myocarditis treated with percutaneous cardiopulmonary support (PCPS) was compared with the outcome of those not treated with PCPS. METHODS AND RESULTS From 1991 to 2000, 14 patients with fulminant myocarditis (left ventricle ejection fraction (LVEF) < or =40%) were admitted to hospital. PCPS was necessary for treatment of shock in 8 (PCPS group), but not for the remaining 6 patients (non-PCPS group). In the PCPS group, 6 patients (75%) survived the critical phase and did not have any cardiac problems after discharge (range of follow-up period, 1.4-6.0 years). All patients in the non-PCPS group survived the acute phase; 1 patient had congestive heart failure 1.5 years after discharge, and another died from malignancy (follow-up period range, 2.2-9.4 years). Although the left ventricular ejection fraction (LVEF) of the PCPS group was significantly lower than that of the non-PCPS group in the acute phase, there was no significant difference in LVEF between the 2 groups in the chronic phase. CONCLUSION Patients who survive the acute phase crisis of acute myocarditis have a favorable long-term survival rate, whether or not mechanical support is used.
Using chemical shifts to generate structural ensembles for intrinsically disordered proteins with converged distributions of secondary structure

A short segment of the disordered p53 transactivation domain (p53TAD) forms an amphipathic helix when bound to the E3 ubiquitin ligase, MDM2. In the unbound p53TAD, this short segment has transient helical secondary structure. Using a method that combines broad sampling of conformational space with re-weighting, it is shown that it is possible to generate multiple, independent structural ensembles that have highly similar secondary structure distributions for both p53TAD and a P27A mutant. Fractional amounts of transient helical secondary structure were found at the MDM2 binding site that are very similar to estimates based directly on experimental observations. Structures were identified in these ensembles containing segments that are highly similar to short p53 peptides bound to MDM2, even though the ensembles were re-weighted using unbound experimental data. Ensembles were generated using chemical shift data (alpha carbon only, or in combination with other chemical shifts) and cross-validated by predicting residual dipolar couplings. We think this ensemble generator could be used to predict the bound state structure of protein interaction sites in IDPs if there are detectable amounts of matching transient secondary structure in the unbound state.
Progesterone and preterm labor--still no definite answers.

In 1930, Willard Allen and George Corner named the steroid hormone that they had extracted from rabbit ovaries “progestin” because they believed, rightly, that it helped maintain pregnancy.1 Removal of progesterone, or blockage of its receptors, reliably ends pregnancy at all gestational ages, and in many nonhuman species, falling levels precipitate natural labor.2 Progestins thus have been an obvious candidate treatment for the major health problem of preterm labor. Therapeutic studies in pregnancy have been limited because natural progesterone given orally is rapidly metabolized in the liver, and synthetic progestins that are not rapidly metabolized have androgenic effects, giving rise .
Retinoic acid‐related orphan receptor alpha reprograms glucose metabolism in glutamine‐deficient hepatoma cells

The metabolism of glutamine and glucose is recognized as a promising therapeutic target for the treatment of cancer; however, targeted molecules that mediate glutamine and glucose metabolism in cancer cells have not been addressed. Here, we show that restricting the supply of glutamine in hepatoma cells, including HepG2 and Hep3B cells, markedly increased the expression of retinoic acid‐related orphan receptor alpha (RORα). Up‐regulation of RORα in glutamine‐deficient hepatoma cells resulted from an increase in the level of cellular reactive oxygen species and in the nicotinamide adenine dinucleotide phosphate/nicotinamide adenine dinucleotide phosphate reduced (NADP+/NADPH) ratio, which was consistent with a reduction in the glutathione/glutathione disulfide (GSH/GSSG) ratio. Adenovirus (Ad)‐mediated overexpression of RORα (Ad‐RORα) or treatment with the RORα activator, SR1078, reduced aerobic glycolysis and down‐regulated biosynthetic pathways in hepatoma cells. Ad‐RORα and SR1078 reduced the expression of pyruvate dehydrogenase kinase 2 (PDK2) and inhibited the phosphorylation of pyruvate dehydrogenase and subsequently shifted pyruvate to complete oxidation. The RORα‐mediated decrease in PDK2 levels was caused by up‐regulation of p21, rather than p53. Furthermore, RORα inhibited hepatoma growth both in vitro and in a xenograft model in vivo. We also found that suppression of PDK2 inhibited hepatoma growth in a xenograft model. These findings mimic the altered glucose utilization and hepatoma growth caused by glutamine deprivation. Finally, tumor tissue from 187 hepatocellular carcinoma patients expressed lower levels of RORα than adjacent nontumor tissue, supporting a potential beneficial effect of RORα activation in the treatment of liver cancer. Conclusion: RORα mediates reprogramming of glucose metabolism in hepatoma cells in response to glutamine deficiency. The relationships established here between glutamine metabolism, RORα expression and signaling, and aerobic glycolysis have implications for therapeutic targeting of liver cancer metabolism. (Hepatology 2015;61:953–964)
The Impact of Situation and Outlook Information in Corn and Soybean Futures Markets: Evidence from WASDE Reports

The purpose of this study was to examine the impact of situation and outlook information from World Agricultural Supply and Demand Estimates (WASDE) in corn and soybean futures markets over the period 1985 to 2006. Results indicate that WASDE reports containing National Agricultural Statistics Service (NASS) crop production estimates and other domestic and international situation and outlook information have the largest impact; causing return variance on report sessions to be 7.38 times greater than normal return variance in corn futures and 6.87 times greater than normal return variance in soybean futures. WASDE reports limited to international situation information and domestic and international outlook information have a smaller impact. The results show that the impact of WASDE reports has increased over time.
16S rRNA Mutation-Mediated Tetracycline Resistance in Helicobacter pylori

ABSTRACT Most Helicobacter pylori strains are susceptible to tetracycline, an antibiotic commonly used for the eradication of H. pylori. However, an increase in incidence of tetracycline resistance in H. pylori has recently been reported. Here the mechanism of tetracycline resistance of the first Dutch tetracycline-resistant (Tetr) H. pylori isolate (strain 181) is investigated. Twelve genes were selected from the genome sequences of H. pylori strains 26695 and J99 as potential candidate genes, based on their homology with tetracycline resistance genes in other bacteria. With the exception of the two 16S rRNA genes, none of the other putative tetracycline resistance genes was able to transfer tetracycline resistance. Genetic transformation of the Tets strain 26695 with smaller overlapping PCR fragments of the 16S rRNA genes of strain 181, revealed that a 361-bp fragment that spanned nucleotides 711 to 1071 was sufficient to transfer resistance. Sequence analysis of the 16S rRNA genes of the Tetr strain 181, the Tets strain 26695, and four Tetr 26695 transformants showed that a single triple-base-pair substitution, AGA926-928→TTC, was present within this 361-bp fragment. This triple-base-pair substitution, present in both copies of the 16S rRNA gene of all our TetrH. pylori transformants, resulted in an increased MIC of tetracycline that was identical to that for the Tetr strain 181.
Thirty-day morbidity and mortality rates for carotid artery intervention by surgeons who perform both carotid endarterectomy and carotid artery angioplasty and stent placement.

OBJECT There is no known standard 30-day morbidity and mortality rate for high-risk patients undergoing carotid artery (CA) angioplasty and stent (CAS) placement. The high-risk registries and the Stenting and Angioplasty with Protection in Patients at High Risk for Endarterectomy, Carotid Revascularization using Endarterectomy or Stenting Systems, and European Long-term Carotid Artery Stenting trials report different rates of morbidity and mortality, and each high-risk cohort has a different risk profile. The applicability of carotid endarterectomy (CEA) results from North American Symptomatic Carotid Endarterectomy Trial/Asymptomatic Carotid Atherosclerosis Study (NASCET/ACAS) remains uncertain, as most clinical CAS placement series reported to date typically included patients who would not have qualified for those studies. At the University at Buffalo, the same neurosurgeons perform triage in patients with CA disease and perform both CEA and CAS insertion. The authors review morbidity and mortality rates in this practice model. METHODS Diagnosis-related group codes were used to search the authors' practice database for patients who had undergone a completed CA intervention solely for the indication of atherosclerotic disease. One hundred twenty patients (129 vessels) treated with CAS surgery and 95 patients (100 vessels) treated with CEA met these criteria. In the CAS placement group, 78% of the patients would not have met NASCET/ACAS inclusion criteria. Demographic and clinical data for both groups were recorded on a spreadsheet for analysis. At 30 days, one patient in the CEA group and two in the CAS group had died. Stroke occurred in one patient in the CAS group and none in the CEA group. Myocardial infarction (MI) occurred in one patient who underwent CAS surgery compared with three undergoing CEA. Composite incidence of stroke/death/MI was 3.3% in the CAS group and 3.2% in the CEA group. CONCLUSIONS In a practice in which surgeons perform both CEA and CAS surgery, the event rates for the CAS surgery equivalent to NASCET and ACAS rates for CEA can be achieved, even in high-risk NASCET/ACAS-ineligible patients in 78% of the CAS cases.
Historical Accumulation of Nonindigenous Forest Pests in the Continental United States

Nonindigenous forest insects and pathogens affect a range of ecosystems, industries, and property owners in the United States. Evaluating temporal patterns in the accumulation of these nonindigenous forest pests can inform regulatory and policy decisions. We compiled a comprehensive species list to assess the accumulation rates of nonindigenous forest insects and pathogens established in the United States. More than 450 nonindigenous insects and at least 16 pathogens have colonized forest and urban trees since European settlement. Approximately 2.5 established nonindigenous forest insects per year were detected in the United States between 1860 and 2006. At least 14% of these insects and all 16 pathogens have caused notable damage to trees. Although sap feeders and foliage feeders dominated the comprehensive list, phloem- and wood-boring insects and foliage feeders were often more damaging than expected. Detections of insects that feed on phloem or wood have increased markedly in recent years.
Energy utilization and growth performance of broilers receiving diets supplemented with enzymes containing carbohydrase or phytase activity individually or in combination

Energy utilization in broilers as influenced by supplementation of enzymes containing phytase or carbohydrase activities was investigated. Day-old male broilers (480) were allocated to four slaughter groups, thirty broilers in the initial slaughter group and 150 broilers in each of the final slaughter groups on days 7, 14 and 21. Broilers in each of the final slaughter groups were allocated to five treatments in a randomized complete block design, each treatment had six replicate cages of five broilers per replicate cage. The diets were maize–soyabean based with wheat as a source of NSP. The treatments were: (1) positive control that met nutrient requirements of the day-old broiler chick; (2) negative control (NC) deficient in metabolizable energy and P; (3) NC plus phytase added at 1000 FTU/kg; (4) NC plus cocktail of xylanase, amylase and protease (XAP); and (5) NC plus phytase and XAP. Gain and gain:food were depressed (P < 0·05) in the NC diet. Phytase improved (P < 0·05) gain at all ages and gain:food at days 0–14 and days 0–21. There was improvement (P < 0·01) in net energy for production, energy retained as fat and protein from days 0 to 14 and from days 0 to 21 in phytase-supplemented diet compared with the NC diet. Net energy for production was more highly correlated with performance criteria than metabolizable energy and may be a more sensitive energy utilization response criterion to use in evaluating broiler response to enzyme supplementation.
Queixas musculoesqueléticas e a prática de ginástica laboral de colaboradores de instituição financeira

Este estudo identificou as queixas musculoesqueleticas de 16 trabalhadores de uma instituicao financeira, praticantes e nao praticantes de ginastica laboral, por meio do questionario do mapa corporal. Para a analise dos dados foi utilizado o teste qui-quadrado com nivel de significância de 5%. O grupo da ginastica laboral mostrou resultados positivos apenas para a analise da regao cervical (p = 0,049), sendo as queixas nesta regao mais leves (44,44%; n = 4) quando comparadas as apresentadas pelos individuos nao praticantes de gnastica laboral. Esses trabalhadores, por sua vez, apresentaram queixas mais intensas como as moderadas (intensidade 3) (42,86%; n = 3) e consideraveis (intensidade 4) (57,14%; n = 4). As praticas em ginastica laboral, realizadas duas vezes na semana, nao foram suficientes para diferenciar a intensidade das queixas musculoesqueleticas na maioria das regioes corporais analisadas, indicando a necessidades de adequacao das atividades realizadas visando maior efetividade em termos musculoesqueleticos.
Performance analysis of mixed amplify-and-forward and decode-and-forward protocol in underlay cognitive networks

In this paper, we propose and evaluate outage performance of a mixed amplify-and-forward (AF) and decode-and-forward (DF) relaying protocol in underlay cognitive radio. Different from the conventional AF and DF protocols, in the proposed protocol, a secondary source attempts to transmit its signal to a secondary destination with help of two secondary relays. One secondary relay always operates in AF mode, while the remaining one always operates in DF mode. Moreover, we also propose a relay selection method, which relies on the decoding status at the DF relay. For performance evaluation and comparison, we derive the exact and approximate closed-form expressions of the outage probability for the proposed protocol over Rayleigh fading channel. Finally, we run Monte Carlo simulations to verify the derivations. Results presented that the proposed protocol obtains a diversity order of three and the outage performance of our scheme is between that of the conventional underlay DF protocol and that of the conventional underlay AF protocol.
Specificity of first-line tests for the diagnosis of Cushing's syndrome: assessment in a large series.

CONTEXT The diagnosis of Cushing's syndrome requires highly sensitive screening tests. Therefore, diagnostic cutoffs have been lowered to maximize sensitivity and identify all patients. However, few studies have investigated the impact of these refinements on the specificity of first-line tests. OBJECTIVE The aim of the study was the assessment of the specificity of three widely used screening tests in a large series of Cushing's syndrome suspects referred to our endocrine service. PATIENTS We retrospectively reviewed the results of urinary free cortisol (UFC), 1-mg dexamethasone suppression test [overnight suppression test (OST)], and serum cortisol at midnight in 3,461, 357, and 864 patients, respectively, with clinical features suggestive of Cushing's syndrome but in whom this diagnosis was subsequently excluded. RESULTS UFC and OST at the 5-microg/dl cutoff exhibited the highest specificities [91% (95% confidence intervals [CI] 90.2-92.1%) and 97% (95% CI 96.3-98.5%), respectively]. Conversely, midnight serum cortisol yielded 87% (95% CI 84.3-91.1%) specificity only with the 7.5-microg/dl cutoff, whereas the 1.8-microg/dl threshold resulted in an unacceptably high proportion of false positives at only 20% specificity (95% CI 16.0-24.4%). Gender and age may lead to misleading results in all three screening tests. CONCLUSIONS Specificity of tests for Cushing's syndrome varies considerably, with OST and UFC presenting the best performances, and circadian rhythm appearing heavily impaired by lowering of diagnostic cutoffs. Indeed, the vast majority of individuals in our series presented midnight serum cortisol values greater than 1.8 microg/dl; thus, caution has to be exercised when this criterion is used to exclude Cushing's syndrome.