Miracle-dz/UniFAR-FTUs huggingface dataset:
Using incident reports to inform the prevention of medication administration errors

AIMS AND OBJECTIVES To describe ways of preventing medication administration errors based on reporters' views expressed in medication administration incident reports. BACKGROUND Medication administration errors are very common, and nurses play important roles in committing and in preventing such errors. Thus far, incident reporters' perceptions of how to prevent medication administration errors have rarely been analysed. DESIGN AND METHODS This is a qualitative, descriptive study using an inductive content analysis of the incident reports related to medication administration errors (n = 1012). These free-text descriptions include reporters' views on preventing the reoccurrence of medication administration errors. The data were collected from two hospitals in Finland and pertain to incidents that were reported between 1 January 2013 and 31 December 2014. RESULTS Reporters' views on preventing medication administration errors were divided into three main categories related to individuals (health professionals), teams and organisations. The following categories related to individuals in preventing medication administration errors were identified: (1) accuracy and preciseness; (2) verification; and (3) following the guidelines, responsibility and attitude towards work. The team categories were as follows: (1) distribution of work; (2) flow of information and cooperation; and (3) documenting and marking the drug information. The categories related to organisation were as follows: (1) work environment; (2) resources; (3) training; (4) guidelines; and (5) development of the work. CONCLUSIONS Health professionals should administer medication with a high moral awareness and an attempt to concentrate on the task. Nonetheless, the system should support health professionals by providing a reasonable work environment and encouraging collaboration among the providers to facilitate the safe administration of medication. RELEVANCE TO CLINICAL PRACTICE Although there are numerous approaches to supporting medication safety, approaches that support the ability of individual health professionals to manage daily medications should be prioritised.
Registrars' and senior registrars' perceptions of their audit activities.

OBJECTIVES--To ascertain the level and quality of audit activity among junior doctors, their attitudes to audit, and their views on its educational value. DESIGN--Postal questionnaire survey in April 1991. SETTING--Yorkshire region. SUBJECTS--All 610 registrars and senior registrars recorded as employed in the region. MAIN MEASURES--Grade, current specialty, details of last audit participated in and its educational usefulness, and attitude to audit. RESULTS--255 (41.8%) completed questionnaires were returned, 148 from registrars and 101 from senior registrars; grade was not indicated in six. 27 respondents were in general medicine, 26 in general surgery, 30 in anaesthetics, and 36 in psychiatry; other specialties had fewer than 20 respondents. About a fifth (54) of respondents, most in psychiatry (19/36, 53%), had not participated in audit. Among the 201 who had participated, the audit topics covered most components of care (access to services (47, 23%), communication (51, 25%), and appropriateness (158, 79%) and effectiveness (157, 78%) of treatment); only 84 (41%) audits set standards, and in only half of them had the doctors been involved in doing so. Doctors responsible for gathering data and those responsible for collating and reporting data found their experience significantly less useful than those who were not. 172 (86%) respondents considered that audit had helped patient care. Suggested improvements to the educational value of audit were mostly for better methods but included requests for less "witch hunting," better feedback, more training, more time, and more participation by consultants. CONCLUSIONS--The educational value of audit to junior doctors could be improved by better audit methods, guidance, and feedback.
Approaches to Delivery of Care at Home Following Elective Hip and Knee Joint Replacement Surgery

Arthritis has a worldwide increasing prevalence with increased demands on healthcare systems to provide arthroplasty surgery. There is growing evidence that early discharge and rehabilitation at home following hip and knee replacement provide similar or better results in function, complication rates and patient satisfaction. We suggest that this method of rehabilitation is a cost-effective viable option in fitter patients whose medical demands will be low postoperatively.
Effects of NorA Inhibitors on In Vitro Antibacterial Activities and Postantibiotic Effects of Levofloxacin, Ciprofloxacin, and Norfloxacin in Genetically Related Strains ofStaphylococcus aureus

ABSTRACT NorA is a membrane-associated multidrug efflux protein that can decrease susceptibility to fluoroquinolones in Staphylococcus aureus. To determine the effect of NorA inhibition on the pharmacodynamics of fluoroquinolones, we evaluated the activities of levofloxacin, ciprofloxacin, and norfloxacin with and without various NorA inhibitors against three genetically related strains of S. aureus (SA 1199, the wild-type; SA 1199B, a NorA hyperproducer with a grlA mutation; and SA 1199-3, a strain that inducibly hyperproduces NorA) using susceptibility testing, time-kill curves, and postantibiotic effect (PAE) methods. Levofloxacin had the most potent activity against all three strains and was minimally affected by addition of NorA inhibitors. In contrast, reserpine, omeprazole, and lansoprazole produced 4-fold decreases in ciprofloxacin and norfloxacin MICs and MBCs for SA 1199 and 4- to 16-fold decreases for both SA 1199B and SA 1199-3. In time-kill experiments reserpine, omeprazole, or lansoprazole increased levofloxacin activity against SA 1199-3 alone by 2 log10CFU/ml and increased norfloxacin and ciprofloxacin activities against all three strains by 0.5 to 4 log10 CFU/ml. Reserpine and omeprazole increased norfloxacin PAEs on SA 1199, SA 1199B, and SA 1199-3 from 0.9, 0.6, and 0.2 h to 2.5 to 4.5, 1.1 to 1.3, and 0.4 to 1.1 h, respectively; similar effects were observed with ciprofloxacin. Reserpine and omeprazole increased the levofloxacin PAE only on SA 1199B (from 1.6 to 5.0 and 3.1 h, respectively). In conclusion, the NorA inhibitors dramatically improved the activities of the more hydrophilic fluoroquinolones (norfloxacin and ciprofloxacin). These compounds may restore the activities of these fluoroquinolones against resistant strains of S. aureus or may potentially enhance their activities against sensitive strains.
Comparison of methods for serotyping isolates of Haemophilus influenzae

This study compared four methods for serotyping isolates of Haemophilus influenzae. Slide agglutination with commercial antisera (Difco Laboratories and Wellcome Diagnostics), coagglutination (Phadebact Haemophilus Test [Pharmacia Fine Chemicals]), latex agglutination with affinity-purified anticapsular antibody, and counterimmunoelectrophoresis with multiple antisera were used to serotype 80 isolates of H. influenzae. Coagglutination and counterimmunoelectrophoresis correctly identified all 80 isolates as either type b or not type b. Slide agglutination and latex agglutination each successfully identified 76 of the 80 isolates; however, each of these two methods failed to type four isolates because of agglutination of controls. We recommend slide agglutination or coagglutination as the serotyping methods of choice in most laboratories because they are simple, accurate, and rapid. Slide agglutination with Difco antiserum can be performed at the lowest cost.
Angular-momentum-insensitive quantum-defect theory for diatomic systems

We show that the highly excited rovibrational spectra of a diatomic molecule and the closely related slow atomic collision processes contain more systematics and require less parameters to characterize than the Rydberg spectrum of an atom. In the case of a single channel, e.g., we show that a singleshort-range parameter gives a complete description of slow collisions for practically all angular momenta, and covers an energy range of hundreds of millikelvins. Thesameparameter also describes the highly excited rovibrational spectra in the threshold region, including states of different angular momenta. Sample applications and predictions of the theory are presented, including comparisons with experiment.
Moderating effect of privacy self-efficacy on location-based mobile marketing

This study analyses the effects of perceived relevance and perceived vulnerability on approach and avoidance intentions toward location-based mobile marketing LBMM and investigates the moderating effect of privacy self-efficacy PSE. For this, the study considers two types of consumers' approach intentions and two types of their avoidance intentions to provide a better understanding of LBMM adoption. The results of an online survey of 1864 mobile phone users in the USA indicate that perceived relevance had positive effects of both types of consumers' approach intentions but negative effects only on their willingness to refuse. In addition, perceived vulnerability had positive effects on both types of consumers' avoidance intentions as well as their willingness to pretest. PSE had significant moderating effects on the relationships between perceived relevance/perceived vulnerability and approach/avoidance intentions. These results have important theoretical and practical implications.
Automatic Essay Grading System for Short Answers in English Language

Automatic Essay Grading (AEG) system is defined as the computer technology that evaluates and grades written prose. The short essay answer, where the es say is written in short sentences where it has two types the open ended short answer and the close ended sho rt answer where it is our research domain based on the computer subject. The Marking of short essay answers automatically is one of the most complicated domains because it is relying heavily on the semant ic similarity in meaning refers to the degree to wh ich two sentences are similar in the meaning where both used similar words in the meaning, in this case Humans are able to easily judge if a concepts are r elated to each other, there for is a problem when S tudent use a synonym words during the answer in case they forget the target answer and they use their alterna tive words in the answer which will be different from th e Model answer that prepared by the structure. The Standard text similarity measures perform poorly on such tasks. Short answer only provides a limited content, because the length of the text is typicall y short, ranging from a single word to a dozen word s. This research has two propose; the first propose is Alternative Sentence Generator Method in order to generate the alternative model answer by connecting the method with the synonym dictionary. The second proposed three algorithms combined together in matching phase, Commons Words (COW), Longest Common Subsequence (LCS) and Semantic Distance (SD), these algorithms have been successfully used in many Natural Language Processi ng systems and have yielded efficient results. The system was manually tested on 40 questions answered by three students and evaluated by teacher in class. The proposed system has yielded %82 corre lation-style with human grading, which has made the system significantly better than the other stat e of the art systems.
Cyclophosphamide treatment regulates the balance of functional/exhausted tumor-specific CD8+ T cells

ABSTRACT An important question is how chemotherapy may (re-)activate tumor-specific immunity. In this study, we provide a phenotypic, functional and genomic analysis of tumor-specific CD8+ T cells in tumor (P815)-bearing mice, treated or not with cyclophosphamide. Our data show that chemotherapy favors the development of effector-type lymphocytes in tumor bed, characterized by higher KLRG-1 expression, lower PD-1 expression and increased cytotoxicity. This suggests re-engagement of T lymphocytes into the effector program. IFN-I appears involved in this remodeling. Our findings provide some insight into how cyclophosphamide regulates the amplitude and quality of tumor-specific immune responses.
Human monkeypox infection: a family cluster in the midwestern United States.

BACKGROUND The outbreak of monkeypox in the Midwestern United States during June 2003 marks the first documented human infection in the Western Hemisphere. Consistent with those in outbreaks in Africa, most cases in this outbreak were associated with febrile rash illness. We describe a cluster of monkeypox in a family with a spectrum of clinical illness, including encephalitis, and outline the laboratory confirmation of monkeypox. METHODS Standardized patient information was collected by questionnaire and medical chart review; all cases described were laboratory confirmed. Laboratory methods included nucleic acid detection, viral culture, serologic testing, histopathologic evaluation, and immunohistochemical testing. RESULTS Of 3 family members with monkeypox, 2 had rash illness only, and 1 required hospitalization for severe encephalitis. The family member with the mildest clinical course had previously received smallpox vaccination. Diagnostic testing by both polymerase chain reaction and culture revealed infectious monkeypox virus in skin lesions of all 3 patients; 2 patients had orthopoxvirus detected by immunohistochemistry in skin lesions. The patient with encephalitis had orthopoxvirus-reactive immunoglobulin M (IgM) in cerebrospinal fluid. All patients had detectable IgM responses to orthopoxvirus antigens. CONCLUSIONS These 3 patients illustrate a spectrum of clinical illness with monkeypox despite a common source of exposure; manifestation and severity of illness may be affected by age and prior smallpox vaccination. We report that monkeypox, in addition to causing febrile rash illness, causes severe neurologic infection, and we discuss the use of novel laboratory tests for its diagnosis.
If These Walls Could Talk: The Mutual Construction of Organizational Space and Legitimacy

Organizational spaces project claims of organizational legitimacy while also constituting physical environments where work happens. This research questions how organizational space and legitimacy are mutually constituted over time as organizations experience shifts in work and institutional demands.Building on a qualitative case study of Paris Dauphine University, a French university founded in the late 1960s that has, since its inception, occupied the former North Atlantic Treaty Organization headquarters, we theorize the dynamic intersection of organizational space and legitimacy over time. The case study demonstrates how spatial practices of appropriation, reappropriation, and disappropriation intersect with and inform what we call “spatial legacies” that function to establish or repair an alignment between organizational space and legitimacy. Spatial practices of appropriation and reappropriation build and manipulate spatial legacies, whereas spatial practices of disappropriation attempt to break away from such legacies. Appropriation and reappropriation involve managing spatial legacies to maintain the alignment between organizational space and legitimacy claims. Disappropriation involves trying to erase or alter these legacies to realign the space to changing legitimacy claims. This research adds to the literature on sociomateriality by adopting a longitudinal perspective that highlights legacies as nondeterministic outcomes of past imbrications of the social and the material, to research on legitimacy by conceptualizing it as a sociomaterial construction, and to research on organizational spaces by revealing the institutional underpinnings of spatial transformations. This research also holds practical implications by highlighting the relationships between space as it is designed and used and an organization’s legitimacy claims and by showing how claiming the immutability or flexibility of a space can be legitimizing for an organization.
Surgical Treatment of Unresolved Osgood-Schlatter Disease: Ossicle Resection With Tibial Tubercleplasty

The mainstay of treatment of Osgood-Schlatter apophysitis is nonoperative. Surgical treatment has been described for patients who have failed nonoperative management of Osgood-Schlatter disease. The purpose of this study is to evaluate the functional outcome of ossicle excision and tibial tubercleplasty for unresolved Osgood-Schlatter disease that has failed nonoperative treatment. Methods: A retrospective review was performed on 16 knees in 15 patients who underwent ossicle excision and tibial tubercleplasty for unresolved Osgood-Schlatter disease. Functional outcome was assessed using the International Knee Documentation Committee, the Lysholm Knee Scale, and Tegner Activity Score. Results: Twelve patients (75%) returned to preoperative activities and sports, 2 patients (12.5%) partially returned, and 1 patient (6%) did not return. The mean postoperative Lysholm knee score was 76.5. Patients' individual scores ranged from 40 to 100. The mean International Knee Documentation Committee knee score was 75, ranging from 40 to 100. The mean Tegner activity level was 6.8 (range, 3-10). Conclusions: It is our recommendation that when patients fail extensive nonoperative management, surgery to remove the symptomatic ossicle should be offered after skeletal maturity. When this is the case, the addition of tubercleplasty should be performed.
Accrual Accounting, Informational Sufficiency, and Equity Valuation

This paper studies accrual accounting and equity valuation in the context of a firm that makes repeated and overlapping investments in productive capacity. The analysis identifies a particular accrual accounting (depreciation) rule that is termed replacement cost accounting because the book value of existing capacity assets is set equal to the value that such assets would have if a competitive market were to exist for used assets. It is shown that replacement cost accounting aggregates past investment decisions of the firm without a loss of value-relevant information. The intrinsic value of the firm can then be expressed as a function of current accounting data and certain parameters of the firm's operating environment. Further, it is shown that replacement cost accounting is essentially the only accounting rule with this informational sufficiency property.
Antibody response to Rocky Mountain spotted fever

Various techniques were compared to determine the most sensitive method for detection of rocky Mountain spotted fever antibody. A radiometabolic technique for detection of Rocky Mountain spotted fever antibody is also described. In infected monkeys, the fluorescent antibody technique yielded the earliest evidence of seroconversion; with some monkeys the microagglutination procedure was equally effective. The fluorescent antibody and microagglutination measurements showed higher titers than those for complement fixation, Weil-Felix, or the radiometabolic techniques.
Coinfection of hepatitis B and C viruses and risk of hepatocellular carcinoma: Systematic review and meta‐analysis

A subadditive effect of hepatitis B virus (HBV) and hepatitis C virus (HCV) coinfection is possible because superinfection of one virus tends to inhibit infection of the other virus. However, studies have reported inconsistent findings, and two meta‐analyses of studies from various countries (1998) and China (2005) reported a supraadditive effect for hepatocellular carcinoma (HCC) risk. Thus, we reevaluate HBV/HCV monoinfection and coinfection. Of 411 reports, we included 59 studies that assessed the association between HBV/HCV monoinfection and coinfection for HCC risk. HCC risk because of high/detectable HBV DNA and HBeAg infection was higher than HBsAg infection, whereas anti‐HCV vs anti‐HCV/HCV RNA was not different. Geographically, HCC risk was significantly higher in nonendemic than in HBV or HCV endemic areas. Subadditive effect for HCC risk was presented in recently published studies, cohort studies and studies conducted in HBV/HCV nonendemic areas; an additive effect was presented in studies conducted in HBV endemic areas; a supraadditive effect was presented in previously published studies, case‐control studies and studies conducted in HCV endemic areas. Our results suggest HBV/HCV coinfection for HCC risk is not significantly greater than HBV/HCV monoinfection, and HCC risk due to HBV or HCV is higher in nonendemic than endemic areas. The p‐heterogeneity was significant for most analyses, except HBV(+)/HCV(+) and HBV biomarker analyses. Prevention strategies targeted toward HBV or HCV monoinfected patients are needed. In addition, tailored prevention to reduce infectivity such as HBV markers (HBeAg, HBV DNA) is needed.
Estimation of spontaneous blinking main sequence in normal subjects and patients with Graves' upper eyelid retraction.

PURPOSE We quantified the main sequence of spontaneous blinks in normal subjects and Graves' disease patients with upper eyelid retraction using a nonlinear and two linear models, and examined the variability of the main sequence estimated with standard linear regression for 10-minute periods of time. METHODS A total of 20 normal subjects and 12 patients had their spontaneous blinking measured with the magnetic search coil technique when watching a video during one hour. The main sequence was estimated with a power-law function, and with standard and trough the origin linear regressions. Repeated measurements ANOVA was used to test the mean sequence stability of 10-minute bins measured with standard linear regression. RESULTS In 95% of the sample the correlation coefficients of the main sequence ranged from 0.60 to 0.94. Homoscedasticity of the peak velocity was not verified in 20% of the subjects and 25% of the patients. The power-law function provided the best main sequence fitting for subjects and patients. The mean sequence of 10-minute bins measured with standard linear regression did not differ from the one-hour period value. For the entire period of observation and the slope obtained by standard linear regression, the main sequence of the patients was reduced significantly compared to the normal subjects. CONCLUSIONS Standard linear regression is a valid and stable approximation for estimating the main sequence of spontaneous blinking. However, the basic assumptions of the linear regression model should be examined on an individual basis. The maximum velocity of large blinks is slower in Graves' disease patients than in normal subjects.
On the aggregation properties of FMRP – a link with the FXTAS syndrome?

Fragile X mental retardation protein (FMRP) is an RNA binding protein necessary for correct spatiotemporal control of neuronal gene expression in humans. Lack of functional FMRP causes fragile X mental retardation, which is the most common inherited neurodevelopmental disorder in humans. In a previous study, we described the biochemical and biophysical aggregation properties of constructs spanning the conserved region of FMRP and of two other human fragile X related (FXR) proteins, FXR1P and FXR2P. Here, we show that the same regions have an intrinsic tendency to aggregate and spontaneously misfold towards β‐rich structures, also under non‐destabilizing conditions. These findings pave the way to future studies of the mechanism of formation of FXR‐containing ribonucleoprotein granules and suggest a possible link with the as yet poorly understood FXR proteins’ associated pathologies.