Miracle-dz/UniFAR-FTUs huggingface dataset:
Impulsivity in panic disorder: neuropsychological correlates.

BACKGROUND Impulsivity plays a prominent role in numerous psychopathological states and poses an important clinical dilemma. However, different aspects of impulsivity are related to mood disorders, addictions, personality disorders, eating disorders, the relationship between anxiety and impulsivity is controversial and not well explored. The impact of anxiety on cognitive functioning is less explored than in other disorders (e.g. depression). The findings on cognitive functioning and impulsivity in anxiety disorders are inconsistent and are most likely due to methodological differences between the studies. MATERIAL AND METHODS Eleven patients diagnosed with panic disorder (DSM-IV-TR) and nine healthy volunteers were enrolled to the study. Both groups did not differ significantly in terms of age, gender and educational level. The experimental group comprised of psychotropic drug naïve patients. The severity of PD was measured with Panic and Agoraphobia Scale. Impulsiveness was evaluated with the Barratt Impulsiveness Scale - 11th version (BIS-11). To asses cognitive functions CANTAB (Cambridge Neuropsychological Test Automated Battery) was used and Paired Associate Learning (PAL) test was chosen for episodic memory evaluation. RESULTS Mean BIS-11 scores observed in the group of psychotropic drug naïve patients with panic disorder were 71.36 (SD 7.31). Mean BIS-scores recorded in the control group were 60.77 (SD 9.57). The correlation between impulsivity and PAL results in the experimental group was found at the level r=0.708723; p<0.05. The respective value for the controls was r=0.200839; p<0.05. CONCLUSIONS Impulsivity in the experimental group was higher than adjusted average for the control group. Our findings indicate also the correlation between impulsivity and cognitive deficits in panic disorder in psychotropic drug naïve patients.
Genomic Characterization of Enterobacter cloacae Isolates from China That Coproduce KPC-3 and NDM-1 Carbapenemases

ABSTRACT Here, we report two Enterobacter cloacae sequence type 231 isolates coproducing KPC-3 and NDM-1 that have caused lethal infections in a tertiary hospital in China. The blaNDM-1-harboring plasmids carry IncA/C2 and IncR replicons, showing a mosaic plasmid structure, and the blaNDM-1 is harbored on a novel class I integron-like element. blaKPC-3 is located on a Tn3-ΔblaTEM-1-blaKPC-3-ΔTn1722 element, flanked by two 9-bp direct-repeat sequences and harbored on an IncX6 plasmid.
Cubeb Oil Lures: Terpenoid Emissions, Trapping Efficacy, and Longevity for Attraction of Redbay Ambrosia Beetle (Coleoptera: Curculionidae: Scolytinae)

ABSTRACT Redbay ambrosia beetle, Xyleborus glabratus Eichhoff, is an exotic wood borer and the primary vector of Raffaelea lauricola, a symbiotic fungus that causes laurel wilt. This lethal disease has decimated native redbay [Persea borbonia (L.) Sprengel] and swampbay [Persea palustris (Rafinesque) Sargent] throughout southeastern U.S. forests, and currently threatens avocado (Persea americana Miller) in Florida. To curtail the spread of laurel wilt, effective attractants are needed for early detection of the vector. Phoebe oil lures were the best known attractant for X. glabratus, but they are no longer available. The current detection system uses manuka oil lures, but previous research indicated that manuka lures have a short field life in Florida. Recently, cubeb oil was identified as a new attractant for X. glabratus, and cubeb bubble lures are now available commercially. This study compared trapping efficacy and field longevity of cubeb and manuka lures with phoebe lures that had been in storage since 2010 over a 12-wk period in south Florida. In addition, terpenoid emissions were quantified from cubeb and manuka lures aged outdoors for 12 wk. Captures were comparable with all three lures for 3 wk, but by 4 wk, captures with manuka were significantly less. Equivalent captures were obtained with cubeb and phoebe lures for 7 wk, but captures with cubeb were significantly greater from 8 to 12 wk. Our results indicate that cubeb bubble lures are the most effective tool currently available for detection of X. glabratus, with a field life of 3 months due to extended low release of attractive sesquiterpenes, primarily &agr;-copaene and &agr;-cubebene.
Assembly and response rules: two goals for predictive community ecology

Abstract. Assembly rules provide one possible unifying framework for community ecology. Given a species pool, and measured traits for each species, the objective is to specify which traits (and therefore which subset of species) will occur in a particular environment. Because the problem primarily involves traits and environments, answers should be generalizable to systems with very different taxonomic composition. In this context, the environment functions like a filter (or sieve) removing all species lacking specified combinations of traits. In this way, assembly rules are a community level analogue of natural selection. Response rules follow a similar process except that they transform a vector of species abundances to a new vector using the same information. Examples already exist from a range of habitats, scales, and kinds of organisms.
Rabbit antibody responses to experimental infestation with Dermatobia hominis

Abstract. The three larval stages of Dermatobia hominis (Linnaeus) have been evaluated for their immunogenicity by ELISA and immunodiffusion (ID) using sera from experimentally infested rabbits. During a primary infestation, first instar D.hominis were found to cause most reaction and allowed the earliest diagnosis by ELISA. An inhibition of the antibody response against second and third instars was observed. The inhibition disappeared after departure of the larvae from the host. In experimentally immunized hosts the antibody response, following challenge, was highest against second and third instar antigens. Antibody remained elevated during the infestation but fell immediately after the larvae had left the host.
Noiseless Fully Homomorphic Encryption

We try to propose two fully homomorphic encryption (FHE) schemes, one for symmetric (aka. secret-key) settings and another under asymmetric (aka. public-key) scenario. The presented schemes are noiseless in the sense that there is no “noise” factor contained in the ciphertexts. Or equivalently, before performing fully homomorphic computations, our schemes do not incorporate any noise-control process (such as bootstrapping, modulus switching, etc) to refresh the ciphertexts, since our fully homomorphic operations do not induce any noise. Instead of decrypting approximately, our proposal works in an exact homomorphic manner, no matter the inputs are the first-hand ciphertexts that come from the encryptions of plaintexts, or the second-hand ciphertexts that come from homomorphic combinations of other ciphertexts. Therefore in essential, our schemes have no limitation on the depth of the fully homomorphic operations over the ciphertexts. Our solution is comprised of three steps. First, Ostrovsky and Skeith’s idea for building FHE from a multiplicative homomorphic encryption (MHE) over a non-abelian simple group is extended so that FHE can be built from an MHE over a group ring that takes an underlying non-abelian simple group as the natural embedding. Second, non-trivial zero factors of the underlying ring are plugged into the encoding process for entirely removing the noise after fully homomorphic operations, and a slight but significant modification towards Ostrovsky-Skeith’s NAND gate representation is also introduced for avoiding computing inverse matrices of the underlying group ring. In such manner, a symmetric FHE scheme is produced. Finally, based on the proposed symmetric FHE scheme, an asymmetric FHE scheme is built by taking a similar diagram to the well-known GM84 scheme. But different from GM84 that only supports ciphertext homomorphism according to the logically incomplete gate XOR, our scheme supports ciphertext homomorphism according to the logically complete gate NAND. ACM ISBN 000-0-0000-0000-0. DOI: 00.0000/0000
Chromosome 19p13 loci in Finnish migraine with aura families

Chromosomal area 19p13 contains two migraine associated genes: a Cav2.1 (P/Q‐type) calcium channel α1 subunit gene, CACNA1A, and an insulin receptor gene, INSR. Missense mutations in CACNA1A cause a rare Mendelian form of migraine, familial hemiplegic migraine type 1 (FHM1). Contribution of CACNA1A locus has also been studied in the common forms of migraine, migraine with (MA) and without aura (MO), but the results have been contradictory. The role of INSR is less well established: A region on 19p13 separate from CACNA1A was recently reported to be a major locus for migraine and subsequently, the INSR gene was associated with MA and MO. Our aim was to clarify the role of these loci in MA families by analyzing 72 multigenerational Finnish MA families, the largest family sample so far. We hypothesized that the potential major contribution of the 19p13 loci should be detected in a family sample of this size, and this was confirmed by simulations. We genotyped eight polymorphic microsatellite markers surrounding the INSR and CACNA1A genes on 757 individuals. Using parametric and non‐parametric linkage analysis, none of the studied markers showed any evidence of linkage to MA either under locus homogeneity or heterogeneity. However, marginally positive lod scores were observed in three families, and thus for these families the results remain inconclusive. The overall conclusion is that our study did not provide evidence of a major MA susceptibility region on 19p13 and thus we were not able to replicate the INSR locus finding. © 2004 Wiley‐Liss, Inc.
Gate-oxide early-life failure identification using delay shifts

This paper presents experimental data from digital circuits on 90nm test chips, together with circuit simulations, to establish the following results: 1. The presence of a gate-oxide early-life failure (ELF) candidate transistor (also called infant mortality) in a logic gate results in delay shifts over time; 2. Delay shifts can be effective indicators of gate-oxide ELF suspects that may be detected using inexpensive digital techniques. These results can be utilized to overcome scaled-CMOS reliability challenges through effective ELF screening during production test or on-line during system operation for systems with built-in self-healing.
Chromatin Remodeling around Nucleosome-Free Regions Leads to Repression of Noncoding RNA Transcription

ABSTRACT Nucleosome-free regions (NFRs) at the 5′ and 3′ ends of genes are general sites of transcription initiation for mRNA and noncoding RNA (ncRNA). The presence of NFRs within transcriptional regulatory regions and the conserved location of transcription start sites at NFRs strongly suggest that the regulation of NFRs profoundly affects transcription initiation. To date, multiple factors are known to facilitate transcription initiation by positively regulating the formation and/or size of NFRs in vivo. However, mechanisms to repress transcription by negatively regulating the size of NFRs have not been identified. We identified four distinct classes of NFRs located at the 5′ and 3′ ends of genes, within open reading frames (ORFs), and far from ORFs. The ATP-dependent chromatin-remodeling enzyme Isw2 was found enriched at all classes of NFRs. Analysis of RNA levels also demonstrated Isw2 is required to repress ncRNA transcription from many of these NFRs. Thus, by the systematic annotation of NFRs across the yeast genome and analysis of ncRNA transcription, we established, for the first time, a mechanism by which NFR size is negatively regulated to repress ncRNA transcription from NFRs. Finally, we provide evidence suggesting that one biological consequence of repression of ncRNA, by Isw2 or by the exosome, is prevention of transcriptional interference of mRNA.
Comparison of techniques for estimation of forage dry matter intake by grazing beef cattle

Four techniques were compared for their ability to estimate forage dry matter intake (DMI) of grazing animals. In the Cage technique, 10 grazing cages were placed within each pasture, and forage inside and outside the cages was clipped from 0.25-m2 quadrats after 12 to 20 d of grazing. The difference between forage inside and outside the grazing cage represented forage consumed by grazing animals. The second technique used n-alkane controlled release capsules to measure DMI of individual grazing animals (N-alkane marker technique). The remaining two techniques were prediction equations; one utilized body weight (BW) and average daily gain (ADG) to estimate DMI (Minson equation) and the other related dietary net energy concentration and BW to DMI (Net Energy equation). The four methodologies were applied to a 3-yr study evaluating liquid hog manure on the productivity of grass pastures. The study utilized steers of a relatively uniform body size on six continuously grazed grass pastures. When individual an.
Evaluation of the Mutagenic Properties of Two Lignans from Acanthopanax koreanum Nakai

Acanthopanax koreanum Nakai, a well known traditional herb grown in Jeju Island, South of Korea, has been used as a tonic and sedative agent, as well as in the treatment of diabetes and immune diseases. Mutagenicity of two lignans, syringaresinol and tortoside A isolated from A. koreanum , was assessed using Salmonella /microsome (Ames) test. Tester strains used were Salmonella typhimurium TA98, TA100, TA1535, and Escherichia coli WP2 uvr A. The mutagenic activity was determined both in the absence or presence of S9 mixture. As a result, tortoside A did not cause any increase in the number of his+ revertants in S. typhimurium and E. coli WP2 uvr A strains in the presence or absence of S9 mix, compared to the controls. Similarly, low concentrations of syringaresinol (750 and 1,500 µg/plate) did not show any mutagenic properties in all bacterial strains, in the presence or absence of S9 mixture. However, in the high concentration of syringaresinol (3,000 µg/plate), the number of revertants were increased in TA1535 strains, in the absence of S9 metabolic activation. Therefore, in vivo experiments such as comet assay are needed to further determine the genotoxic/carciogenic potential of syringaresinol isolated from A. koreanum .
A Review of Mouse Mutants as Genetic Models of Epilepsy

Summary: Here we review the major inherited convulsive disorders found in mice and discuss their possible relationship to specific clinical seizure disorders in humans. These mouse disorders include audiogenic seizures, the epilepsy (El) mutation, spontaneous seizures, the tottering/learner syndrome, cerebellar abnormalities, myelin disorders, and alcohol withdrawal seizures. Some of these disorders are symptomatic and others are idiopathic. We find that for many major types of epilepsy in humans there exists a similar counterpart in mice. Because the genetic constitution of the mouse is better known and more easily manipulated than that of other mammalian species, the mouse may serve as an excellent animal model for genetic and biochemical studies of epilepsy.
Carotenoids and retinoids metabolites as precursors of receptors-specific bioactive compounds . Advances in shrimp 1

Additional efforts need to be devoted to understanding of the bioactive forms of non-produced de novo metabolites such as carotenoids and their derived metabolites, retinoids in crustaceans. Dietary carotenoids are the sole biological precursos of retinoids in animal systems. The results obtained in survival, gonadosomatic and hepatosomatic index in treatments with carotenoids and retinol, demonstrated the importance of carotenoids to yield retinal and retinol needed for significicantly better gonad development. A rough correlation exists between the rate of retinal formation and the biological activity of the administered carotenoids. The presence of 9-cis and 13-cis retinol in reproductive tissue of P. vannamei shrimp points-out their role in the RXR receptors due to the previously reported function of these isomers in the binding domains fo genes which induces growth and development by controlling the production of local morphogenic signals by a nuclear receptor signaling pathway.
Performance analysis of generalized selection combining with threshold test per branch (T-GSC)

We analyze the average bit error rate and outage probability performance of two types of conditional diversity combining schemes in which each branch signal-to-noise ratio is tested against a fixed predetermined threshold and applied to the combiner only if its value exceeds this threshold. The two schemes, respectively referred to as absolute threshold generalized selection combining and normalized threshold generalized selection combining differ from one another only in the manner in which the threshold is chosen. Nevertheless, when operating over a generalized fading channel, the two schemes have a markedly different behavior as reflected in the numerical results presented. The analytical method taken to obtain these results follows the moment generating function approach used previously by the authors for analyzing the performance of more conventional diversity combining schemes.
The rating game.

is 24.3% better than 24.6%? When 24.3% is the rernrn on the Vanguard Index 500 fund, and 24.6% is the rernrn on the Vanguard Index Small Company fund. According to the Wall Street Journal murnal fund rabIe, the 24.3% rernrn on the Vanguard Index 500 fund over the year ending June 20, 1996, merited an A rating, while the higher 24.6% return on the Vanguard Index Small Company fund over the same period was worth only a D. People know that a sure way to look tall is to stand neXt to short people, and murnal fund managers know that a sure way to a high standing is a short benchmark. The purpose of this article is to review some of the games that murnal funds play with their investments, their benchmarks, and their customers.
What Factors Influence Motor Complications in Parkinson Disease?: A 10-Year Prospective Study

AbstractThe causes and mechanism behind motor complications in Parkinson disease (PD) are still a subject of debate. Several factors including age at onset, evolution in years, and initial medication can influence the onset and severity of motor complications in PD.We studied patients with recent diagnosis of PD who were followed up prospectively for 10 years. Analysis included the progression of these patients, as measured by the Unified Parkinson Disease Rating Scale scores and the presence of motor complications (motors fluctuations, dyskinesias, and gait freezing) over time. The patient group was studied as a whole and by subgroups classified according to age at onset, initial treatment, and sex.By the end of the first decade, most patients exhibited dyskinesias (91%), motor fluctuations (62%), and freezing of gait (68%). An association was found between several patients’ characteristics and presence of motor complications by 5 years, though not after 10 years of follow up. The apparition of motor fluctuations was mainly related to initial treatment (odds ratio [OR], 3.87). The development of dyskinesias was linked to initial treatment (OR, 8.31), age at onset (OR, 0.90), and sex (OR, 12.87).
Neuronal Control of Drosophila Walking Direction

Backward or Forward Although land animals generally walk forward, they readily switch to walking backward if they sense an obstruction or danger in the path ahead. Such a switch is likely to involve a neural signal sent from the brain down to local motor circuits, instructing these motor circuits to alter the phase at which specific leg muscles are activated. Bidaye et al. (p. 97; see the Perspective by Mann) identified such a neuron in Drosophila, which they call MDN (moonwalker descending neuron). Blocking synaptic transmission from MDN inhibited backward walking, and conversely artificially activating MDN caused flies to walk backward. Activation of descending command neurons in Drosophila induces flies to walk backward. [Also see Perspective by Mann] Most land animals normally walk forward but switch to backward walking upon sensing an obstacle or danger in the path ahead. A change in walking direction is likely to be triggered by descending “command” neurons from the brain that act upon local motor circuits to alter the timing of leg muscle activation. Here we identify descending neurons for backward walking in Drosophila—the MDN neurons. MDN activity is required for flies to walk backward when they encounter an impassable barrier and is sufficient to trigger backward walking under conditions in which flies would otherwise walk forward. We also identify ascending neurons, MAN, that promote persistent backward walking, possibly by inhibiting forward walking. These findings provide an initial glimpse into the circuits and logic that control walking direction in Drosophila.
Nature and linkages of the fatty acids present in the lipid-A component of Salmonella lipopolysaccharides.

Laurie, myristic, palmitic, and 3-d-(–)-myristic acid in a ratio of about 1:1:1:3 are present in the lipid A part of the glycolipid derived from the Re mutant Salmonella minnesota R595. An additional fatty acid, Δ2-tetradecenoic acid found in larger amounts after alkaline treatment was recognized as an artifact formed by a β-elimination reaction from ester-linked 3-myristoxy-myristic acid. Various methods for the stepwise liberation of fatty acids were used to identify their distribution on the backbone of lipid A which consists of β-1,6-linked glucosamine disaccharide units substituted at position 3′ with 2-keto-3-eoxyoctonate and at positions 1 and 4′ with phosphate. It was found that the amino groups of the glucosamine residues are substituted by 3-D-(–)-hydroxymyristic acid whose hydroxyl group is free. The three available hydroxyl groups at positions 3, 4, and 6′ of the glucosamine dissaccharide are substituted by equal amounts of lauric, palmitic, and 3-D-myristoxymyristic acid and, possibly, by smaller amounts of myristic and unsubstituted 3-D-hydroxymyristic acid. A similar structure of lipid A seems to exist in lipopolysaccharides of other Salmonella species.
The role of pleiotropy and linkage in genes affecting a sexual ornament and bone allocation in the chicken

Sexual selection and the ornaments that inform such choices have been extensively studied, particularly from a phenotypic perspective. Although more is being revealed about the genetic architecture of sexual ornaments, much still remains to be discovered. The comb of the chicken is one of the most widely recognized sexual ornaments, which has been shown to be correlated with both fecundity and bone allocation. In this study, we use a combination of multiple intercrosses between White Leghorn populations and wild‐derived Red Junglefowl to, first, map quantitative trait loci (QTL) for bone allocation and, second, to identify expression QTL that correlate and colocalize with comb mass. These candidate quantitative genes were then assessed for potential pleiotropic effects on bone tissue and fecundity traits. We identify genes that correlate with both relative comb mass and bone traits suggesting a combination of both pleiotropy and linkage mediates gene regulatory variation in these traits.