Miracle-dz/UniFAR-FTUs huggingface dataset:
The risk of early occurrence and recurrence of hepatocellular carcinoma in hepatitis C‐infected patients treated with direct‐acting antivirals with and without pegylated interferon: A Belgian experience

Recently, concerns were raised of high rates of HCC recurrence in patients treated with direct‐acting antivirals (DAA) for hepatitis C infection. We investigated the HCC occurrence and recurrence rates within 6 months after treatment with DAA with or without pegylated interferon (PEG‐IFN) in real life. This is a retrospective, multicenter cohort trial, executed in 15 hospitals distributed across Belgium. Populations were matched based on fibrosis score (Metavir F3‐F4). Patients with a Child‐Pugh score ≥ B were excluded. In total, 567 patients were included, of whom 77 were treated with PEG‐IFN+DAA between 2008 and 2013 and 490 with DAA without PEG‐IFN between 2013 and 2015. Patients treated with PEG‐IFN+DAA (53±9y) were younger than patients treated with DAA without PEG‐IFN (59±12y) (P=.001). 47% of patients treated with PEG‐IFN+DAA were in the F4 stage vs 67% of patients treated with DAA without PEG‐IFN (P=.001). Screening was inadequate in 20% of both patient groups (P=.664). The early occurrence rate of HCC was 1.7% and 1.1% in patients treated with DAA with and without PEG‐IFN, respectively (P=.540). The early recurrence rate was 0% in patients treated with PEG‐IFN+DAA and 15.0% in patients treated with DAA without PEG‐IFN (P=.857). There is no difference in early occurrence of new HCC between patients treated with DAA with and without PEG‐IFN. We did observe a high early recurrence rate of HCC in patients treated with DAA without PEG‐IFN. However, these patients were at baseline more at risk for HCC. Finally, in 20%, screening for HCC was inadequate.
Fv-1 host cell restriction of friend leukemia virus: microinjection of unintegrated viral DNA

The murine gene Fv-1 has been shown to exert a major influence over the replication of ecotropic murine leukemia viruses. Studies of the replication of Friend murine leukemia virus have shown that the restriction of viral replication occurs intracellularly after the initiation of viral DNA synthesis. The precise mechanism of the block imposed by the Fv-1 gene product is not completely understood. Our studies of Fv-1 restrictive infection have shown a variable decrease in the accumulation of intracellular unintegrated form I viral DNA. Analysis by microinjection of the viral DNA formed in nonpermissively infected BALB/c cells indicates that this DNA is infectious. These studies indicate that the form I DNA accumulated in nonpermissively infected BALB/c cells contains the complete viral sequences necessary for the production of viral progeny, and therefore, they suggest that the Fv-1 host restrictive mechanism recognizes viral factors other than form I DNA alone. These results support the possibility that Fv-1 host restriction occurs after formation of infectious viral DNA, perhaps at the integration step itself.
Attitudes of female nurses toward the male nurse: a study of occupational segregation.

This study analyzes questionnaire responses from 126 female nurses concerning their attitudes toward the male nurse. Multiple regression analysis is used to differentiate the attitudes of various subgroups of nurses. The employment of male nurses wasfound to be consistent with thefemale nurses' values, the vast majority of whom have positive attitudes toward the male nurse andfeel that more males should be encouraged to enter nursing. Sex was generally viewed as an irrelevant consideration in terms of the nursing role. However, there was some concern that employers may exhibit favoritism toward the males, thus making it more difficult forfemales to advance within their organization. Older nurses and nurses with more extensive contact with male nurses were found to have the most positive attitudes. Since there is no evidence here offemale resistance to male entry into nursing, the "sex-typing" of nursing is undoubtedly due to social, cultural and economic values that provide disincentivesfor males to enter this traditionally female occupation.
Evolution of genome size in Brassicaceae.

BACKGROUND AND AIMS Brassicaceae, with nearly 340 genera and more than 3350 species, anchors the low range of angiosperm genome sizes. The relatively narrow range of DNA content (0.16 pg < 1C < 1.95 pg) was maintained in spite of extensive chromosomal change. The aim of this study was to erect a cytological and molecular phylogenetic framework for a selected subset of the Brassicacae, and use this as a template to examine genome size evolution in Brassicaceae. METHODS DNA contents were determined by flow cytometry and chromosomes were counted for 34 species of the family Brassicaceae and for ten Arabidopsis thaliana ecotypes. The amplified and sequenced ITS region for 23 taxa (plus six other taxa with known ITS sequences) were aligned and used to infer evolutionary relationship by parsimony analysis. KEY RESULTS DNA content in the species studied ranged over 8-fold (1C = 0.16-1.31 pg), and 4.4-fold (1C = 0.16-0.71 pg) excluding allotetraploid Brassica species. The 1C DNA contents of ten Arabidopsis thaliana ecotypes showed little variation, ranging from 0.16 pg to 0.17 pg. CONCLUSIONS The tree roots at an ancestral genome size of approximately 1x = 0.2 pg. Arabidopsis thaliana (1C = 0.16 pg; approximately 157 Mbp) has the smallest genome size in Brassicaceae studied here and apparently represents an evolutionary decrease in genome size. Two other branches that represent probable evolutionary decreases in genome size terminate in Lepidium virginicum and Brassica rapa. Branches in the phylogenetic tree that represent probable evolutionary increases in genome size terminate in Arabidopsis halleri, A. lyrata, Arabis hirsuta, Capsella rubella, Caulanthus heterophyllus, Crucihimalaya, Lepidium sativum, Sisymbrium and Thlaspi arvense. Branches within one clade containing Brassica were identified that represent two ancient ploidy events (2x to 4x and 4x to 6x) that were predicted from published comparative mapping studies.
Effect of low [ATP] on depolarization‐induced Ca2+ release in skeletal muscle fibres of the toad.

1. The effect of low [ATP] on depolarization‐induced Ca2+ release from the sarcoplasmic reticulum (SR) was examined using mechanically skinned skeletal muscle fibres of the toad. The amount of Ca2+ released was determined by examining the extent of SR Ca2+ depletion following a single depolarization in the presence of specified total [ATP] and free [Mg2+] and 1 mM EGTA (< 10 nM Ca2+). 2. Reducing the total [ATP] from 8 to 2 mM did not significantly affect the extent of depolarization‐induced Ca2+ release. When the total [ATP] was lowered to 0.5 mM, depolarization‐induced Ca2+ release was markedly reduced. The additional presence of 1.5 mM AMP did not reverse this effect of low [ATP]. 3. At each total [ATP], elevation of the free [Mg2+] from the normal resting level of 1 mM to 3 mM, caused a similar reduction in depolarization‐induced Ca2+ release. This effect was not due to the concomitant decrease in free [ATP] and occurred independently of the reduction in Ca2+ release observed at very low total [ATP]. 4. These results show myoplasmic [ATP] modulates depolarization‐induced Ca2+ release. Thus, if the total [ATP] near the Ca2+ release channels becomes locally depleted in severely fatigued muscle fibres, it may contribute, in combination with an accompanying increase in free [Mg2+], to the reported reduction in Ca2+ release.
Institutional Responsibility for Social Forestry in Africa: Lessons from Zimbabwe

Social forestry hasfailed in may countries in Africa because the projects have been conceived, designed and implemented by agencies with a commercial forestry orientation. Social forestry must address the needs of farmers and be incorporated in the peasant fann system, using and expanding the existing institutions which service rural development. The lack of appropriate technologies is a major constraint to the success of social forestry. Foresters should play a major role in developing appropriate species and technologies and in the management of indigenous woodlands. Existing agricultural extension agencies are better placed to implement social forestry programmes. An integrated approach to development and land use is essential to maximise growth and ensure the sustainable utilisation of natural resources. Agriculturalists should consider trees, and other indigenous flora and fauna, essential components of the fanning systems they are developing.
In Vitro Three-Dimensional Accuracy of Digital Implant Impressions: The Effect of Implant Angulation.

PURPOSE To compare the three-dimensional (3D) accuracy of conventional impressions (CIs) with digital scans (DSs) using an intraoral scanner (IOS) with intraoral scan bodies (SBs) and varying buccolingual interimplant angulations. A secondary aim was to measure the SB machining tolerance and height with and without application of torque. MATERIALS AND METHODS Three master models (MMs) with two implants simulating an implant-supported three-unit fixed partial denture for bone-level implants were used. The implants had buccolingual interimplant angulations of 0, 10, and 20 degrees. Test models for the CI test groups were made with impression copings and polyether impressions. SBs were attached to the MMs, tightened to 15-Ncm torque, and scanned by an IOS for the DS test groups (six test groups, n = 5). A coordinate measuring machine measured linear distortions (dx, dy, dz), 3D distortions (dR), angular distortions (dθx, dθy), and absolute angular distortions (Absdθx, Absdθy) of the physical CI test models and STL files of the DS virtual models relative to the MMs. Metrology software allowed both physical and virtual measurement of geometric targets that were comparable and allowed computation of relative displacements of implant centroids and axes. RESULTS Mean dR ranged from 31 ± 14.2 to 45 ± 3.4 μm for DS and 18 ± 8.4 to 36 ± 6.5 μm for the CI test groups. Mean Absdθx ranged from 0.041 ± 0.0318 to 0.794 ± 0.2739 degrees for DS and 0.073 ± 0.0618 to 0.545 ± 0.0615 degrees for the CI test groups. Mean Absdθy ranged from 0.075 ± 0.0615 to 0.111 ± 0.0639 degrees for DS and 0.106 ± 0.0773 to 0.195 ± 0.1317 degrees for the CI test groups. Two-way analysis of variance showed that the impression technique (P = .012) and implant angulations (P = .007) had a significant effect on dR. Distortions were mostly in the negative direction for DS test groups. Perfect coaxiality of the SB with the implant was never achieved. For SB to implant machining tolerances, the mean absolute horizontal displacement ranged from 4 ± 1.2 to 7 ± 2.3 μm. The SB dz was -5 ± 3.2 μm, which increased in the negative direction to -11 ± 4.9 μm with torque application (P = .002). CONCLUSION Distortions were found for both DS and CI test groups. The best accuracy was obtained with CIs for parallel implants. With angulated implants, conventional and DSs were not significantly different. Excessive torque application that causes negative dz for SB fit would position the virtual implant at a deeper location compared with reality, resulting in possible framework misfit.
Comparing the efficacy in reducing dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a benchmark commercial desensitizing toothpaste containing 2% potassium ion: an eight-week clinical study in Rome, Italy.

OBJECTIVE The objective of this double-blind dentin hypersensitivity clinical study was to investigate the effectiveness of a new desensitizing toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride as sodium monofluorophosphate (MFP), compared to that of a benchmark commercially available desensitizing toothpaste containing 2% potassium ion, dosed as 5.0% potassium nitrate, and 1450 ppm fluoride as sodium fluoride (NaF). METHODS A total of 80 subjects were entered into the study, and stratified into two balanced groups according to their baseline mean tactile and mean air blast sensitivity scores. The two groups were randomly assigned to use either the new arginine toothpaste or the benchmark commercially available desensitizing toothpaste containing 2% potassium ion. Subjects were instructed to brush their teeth twice daily (morning and evening) for one minute with their assigned toothpaste and a commercially available soft-bristled toothbrush. Dentin hypersensitivity examinations, which included tactile and air blast sensitivity measures, were conducted at baseline, one week, two weeks, four weeks, and eight weeks. Subject examinations were conducted by the same dental examiner at each examination period. RESULTS This clinical study demonstrated that the new toothpaste, containing 8.0% arginine and 1450 ppm fluoride as MFP in a calcium carbonate base, provided a significant reduction in dentin hypersensitivity when used over a period of eight weeks. The study also showed that the new arginine toothpaste provided significantly greater reductions (p < 0.05) in dentin hypersensitivity in response to tactile (38.9%, 28.8%, and 11.6%) and air blast (16.8%, 26.4%, and 33.8%) stimuli than the benchmark commercial desensitizing toothpaste containing 2% potassium ion and 1450 ppm fluoride as NaF in a silica base, after two weeks, four weeks, and eight weeks of product use, respectively. CONCLUSION A new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride as MFP provides significantly increased hypersensitivity relief (p < 0.05) as compared to a benchmark commercial desensitizing toothpaste containing 2% potassium ion, dosed as potassium nitrate, after two weeks, four weeks, and eight weeks of product use.
Alcohol, Patient Compliance and Blood Pressure Control in Hypertensive Patients

The association of self-reported use of alcohol with blood pressure and compliance with antihypertensive medication was studied in a randomly selected population sample in eastern Finland. We found a positive correlation between reported use of alcohol and diastolic blood pressure level and a negative correlation with the reduction of diastolic blood pressure during a five-year treatment. These correlations were independent of age, gender, and blood pressure level 5 years earlier. The use of alcohol was associated, especially in men, with poor compliance with antihypertensive medication. In addition to a possible direct contribution to high blood pressure, alcohol intake resulted in an inadequate control of blood pressure in male hypertensive patients by lowering patient compliance.
Can smartphones measure momentary quality of life and participation? A proof of concept using experience sampling surveys with university students

BACKGROUND Understanding quality of life and participation is a key aspect of occupational therapy research. The use of smartphones to deliver experience-sampling surveys may provide an accessible way to monitor these outcomes. This study used smartphone-based experience sampling methods (ESM) to investigate factors influencing momentary quality of life (mQOL) of university students. METHODS A convenience sample of students at an Australian university participated. Using a custom smartphone application, ESM surveys were sent six to eight times, every second day, over a week. Participants indicated their mQOL, occupational participation, occupational enjoyment, social context and location via surveys and provided demographic and health information in a single self-report questionnaire. The relationship between mQOL and variables was analysed at the survey level using logistic regression. RESULTS Forty students completed 391 surveys. Higher mQOL was significantly related to participation in productive occupations (z = 3.48; P = 0.001), moderate (z = 4.00; P < 0.001) or high occupational enjoyment (z = 7.06; P < 0.001), being with someone (z = 2.15, P = 0.031), being at home (z = 2.49; P = 0.013) and an excellent self-rated health status (z = 2.35; P = 0.019). The magnitude of differences in mQOL was small. CONCLUSION This study suggests that mQOL amongst university students relates to personal, environmental and occupational factors. The use of smartphone-based ESM appears to be a practical approach for investigating participation and QOL. Further research utilising a more diverse sample, analysing at the individual level, and using ESM in conjunction with other methodologies is recommended.
Clinical and microbiologic changes associated with the combined use of a powered toothbrush and a triclosan/copolymer dentifrice: a 3-year prospective study.

BACKGROUND Different means are available for self-performed oral hygiene. The aim of this study was to evaluate the clinical and microbiologic effects of a preventive homecare program including the combined use of a powered toothbrush and a triclosan/copolymer-containing dentifrice. METHODS A total of 160 adult subjects without signs of destructive periodontal disease were recruited for this 3-year randomized controlled trial. The subjects were assigned to a homecare program using an oscillating/rotating powered toothbrush and a triclosan/copolymer/fluoride-containing dentifrice (test) or a manual toothbrush and a standard fluoride-containing dentifrice (control). Supragingival polishing and reinforcement of homecare procedures were provided every 6 months. Plaque, bleeding on probing (BOP), and probing depth (PD) were scored at baseline and after 1, 2, and 3 years. Subgingival plaque samples were taken from the mesial aspect of each tooth at baseline and after 1, 2, and 3 years and were analyzed for their content of 40 bacterial species using checkerboard DNA-DNA hybridization. All data analyses were based on "intention-to-treat" with the subject as the statistical unit. RESULTS Compared to baseline, no significant changes in clinical parameters were observed during the 3 years, except for a reduction in the mean PD at the 2- and 3-year follow-up examinations (P <0.05). No significant differences were found between the two groups with regard to plaque, BOP, or PD or in the mean counts of the 40 species at any time point. CONCLUSION The study failed to prove additional benefits of the combined use of a powered toothbrush and a triclosan/copolymer-containing dentifrice in adult subjects without signs of destructive periodontal disease.
The survival benefit and safety of No. 12a lymphadenectomy for gastric cancer patients with distal or total gastrectomy

There has still not been a consensus in aspects of survival benefit and safety on No.12a lymph nodes (LNs) dissection for gastric cancer patients. This study was aimed to evaluate this issue for patients with distal or total gastrectomy. Patients were retrospectively divided into 12aD+ group (with No.12a dissection) and 12aD–group (without No.12a dissection). Clinicopathologic characteristics, survival rate, morbidity and mortality were compared. There were 670 patients in 12aD+ group, while 567 in 12aD–group. The baselines between the two groups were comparable. The No.12a LNs metastasis ratio was 11.6% and higher in lower third tumor. The metastasis of No.5 LNs, N stage and M stage were correlated to metastasis of No.12a LNs. There was no difference in morbidity nor mortality between the two groups. The 5-year overall survival rates (5-y OS) were 59.6% and 55.1% in 12aD+ group and 12aD–group respectively (P = 0.075). The 5-y OS of patients with negative and positive No.12a LNs were 62.3% and 24.1%. The survival of stage III patients with No.12a positive was better than that of stage IV patients. The 5-y OS were better in 12aD+ group for patients with ages more than 60, lower third tumor, distal gastrectomy, N3 status, or III stages compared with 12aD–group. No.12a lymphadenectomy was independently better prognostic factors for stage III patients. No.12a LNs metastasis should not be considered as distant metastasis. No.12a lymphadenectomy can be performed safely and should be indicated for potentially curable progressive stage tumors requiring distal gastrectomy and might be reserved in patients with stage I or II, or upper third tumor.
Racionalidade limitada e consumo: a configuração de objetivos na tomada de decisão do consumidor

O efeito de configuracao de objetivos refere-se ao achado de que as pessoas respondem de maneiras distintas a diferentes configuracoes de um mesmo material de comunicacao, revelando o carater limitadamente racional das decisoes do consumidor. Nessa direcao, esta tese apresenta como objetivo geral investigar o efeito da configuracao de objetivos na tomada de decisao do consumidor. Como objetivos especificos, pretendeu-se mensurar o impacto da quantidade de informacoes sobre o efeito de configuracao de objetivos, bem como avaliar os efeitos moderadores das variaveis envolvimento do consumidor e Need for Cognition (NfC) no efeito de configuracao de objetivos. Este estudo foi realizado em tres secoes, sendo a primeira uma secao teorica e as demais, secoes empiricas experimentais. Os instrumentos utilizados nas secoes empiricas foram quatro versoes de textos promocionais sobre cartoes de credito (configurados em ganhos e perdas, em quantidades de informacoes resumidas e expandidas), o Consumer Involvement for Credit Card Services Scale (desenvolvido para uso nesta tese) e a Escala Need for Cognition (Deliza, Rosenthal, & Costa, 2003). Os resultados apontaram que o efeito de configuracao de objetivos parece estar associado a acao da intuicao e que ele ocorre: (a) somente frente a quantidades de informacoes resumidas; (b) quando as preferencias do consumidor, em termos de formas de pagamento, sao diversas ao cartao de credito; e (c) entre os consumidores com alto grau de envolvimento com servicos de cartoes de credito (independente do grau de NfC do participante).
Pediatric emergencies in the office: are family physicians as prepared as pediatricians?

OBJECTIVE Our objective was to assess the occurrence of pediatric emergencies in the offices of family physicians and pediatricians, the preparedness to respond, and the perceived importance of being prepared. STUDY DESIGN We performed a cross-sectional random mail survey of physicians. POPULATION Surveys were sent to 187 family physicians and 129 pediatricians practicing in North Carolina with 75% and 86% response rates, respectively. The 169 total respondents were in community practices regularly treating children and were included for analysis. OUTCOMES MEASURED We measured the incidence of 8 types of pediatric emergencies, the availability of 11 items for resuscitation and stabilization, whether the physician had Pediatric Advanced Life Support (PALS) training in the previous 2 years, whether the office ever conducted a mock emergency, and beliefs about the importance of preparing for and providing emergency care to children. RESULTS Six types of pediatric emergencies were seen in one third or more of all practices during the year. The average practice saw 4 or more pediatric emergencies in a year (family physicians = 3.8 vs pediatricians = 4.9, P <.001). Family physicians had fewer resuscitation and stabilization items than pediatricians (5.7 vs 8.6 items, P <.001) and were less prepared in terms of PALS training (19% vs 51%, P <.001). Those with PALS training were more likely to have an intraosseous needle and Broselow tape and to have conducted a mock code. Family physicians considered it is less important than pediatricians to provide such care or to be prepared to do so. CONCLUSIONS Pediatric emergencies in the office are likely for either specialty. Family physicians may be less prepared, and they discount the importance of the problem and need for preparation.