Miracle-dz/UniFAR-FTUs huggingface dataset:
Análise cinemática do movimento uniarticular do punho de sujeitos com e sem doença de Parkinson

A doenca de Parkinson (DP) e uma doenca cronica, neurodegenerativa caracterizada classicamente por quatro sinais/sintomas motores: tremor de repouso, rigidez muscular, bradcinesia e instabilidade postural. Os sinais motores da doenca implicam em dificuldades na execucao e controle dos movimentos. Levando em consideracao a importância da velocidade no controle dos movimentos, em 1989 Gottlieb e colabadores e Corcos et al. propuseram a estrategia dual do movimento que postula que o aumento da distância do movimento e acompanhado com o aumento da duracao de ativacao do pulso ao motoneuronio, e que o aumento da velocidade ou diâmetro do alvo cursa com aumento da amplitude de ativacao do pulso. Desta forma, buscando testar a estrategia dual do movimento, nesta dissertacao sao apresentados tres artigos. O primeiro e uma revisao sistematica sobre os trabalhos que, utilizando a eletromiografia, analisaram o controle dos movimentos uniarticulares dos membros superiores de parkinsonianos. O segundo e o terceiro artigo sao dois estudos transversais que testam em pratica as estrategias pulse-width e pulse-height da estrategia dual do movimento, respectivamente. A revisao de literatura nos mostra que o controle dos movimentos uniarticulares dos membros superiores de parkinsonianos obedecem apenas a estrategia pulse-height de ativacao inicial do motoneuronio. No experimento do segundo artigo, os sujeitos deveriam realizar a flexao do punho em tres distâncias. Enquanto a magnitude de ativacao apresentou-se invariavel ao aumento da distância do movimento, a duracao de ativacao foi significativamente maior para maiores distâncias tanto nos sujeitos com (p=0,015) quanto nos sujeitos sem DP (p=0,020). Nao foi encontrada diferenca na duracao do pulso da aceleracao entre os sujeitos com e sem DP. No experimento do terceiro artigo, os sujeitos deveriam realizar a flexao do punho na mesma distância porem em tres alvos com diferentes diâmetros. O aumento do diâmetro do alvo nao provocou a modulacao da duracao da aceleracao tanto para o grupo com (p=0,920) quanto para o grupo sem (0,939) DP. Ainda, nao foi encontrada diferenca para a duracao entre os dois grupos em nenhum dos diâmetros. Entretanto, a variacao dos diâmetros levou tanto o grupo com (p=0,000) quanto o grupo sem (p=0,004) DP a escalonar a amplitude de ativacao da aceleracao. Comparando os grupos nao foram encontradas diferencas na amplitude do pulso para a variacao do diâmetro dos alvos. Desta forma, os resultados do segundo e terceiro estudo mostram, respectivamente, que os sujeitos com e sem DP obedecem a ambas as estrategias pulse-width e pulse-height da estrategia dual do movimento.
Synthesis and Morphology Control of Gold/Iron Oxide Magnetic Nanocomposites via a Simple Aqueous Method

Gold/iron oxide nanocomposites offer the promise of combining the unique traits of both gold and iron oxide nanomaterials to enable new applications. In this work, a simple and safe method has been established whereby the morphology of gold material in gold/iron oxide nanocomposites can be controlled to be nanowire or nanosphere by adjusting the initial molar ratio of citrate-coated iron oxide nanoparticles to auric acid. Gold/iron oxide nanowires and nanospheres were synthesized through this method. Their structural, optical, and magnetic properties were characterized by transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDS), dynamic light scattering (DLS), ultraviolet-visible spectroscopy (UV-Vis), and vibrating sample magnetometry (VSM). These materials substantially maintained the optical properties of gold nanomaterials and magnetic features of iron oxide magnetic nanoparticles.
THE FATTY ACIDS FROM PLANTS OF THE GENUS ACHILLEA UDC 665 . 12 : 582

The content and composition of fatty acids of three species of Achillea L. : A. lingulata W. et K. , A. nobilis L. and A. crithmifolia W. et K. have been analyzed by GC. It was found that unsaturated acids were prevailing compounds (average U/S was 1.6) and the major components are: palmitic, linoleic and linolenic acids. The ratio of linolenic and linoleic acid were: A. lingulata 1.1, A. nobilis 0.8 and A. crithmifolia 0.2.
Variable immune deficiency related to deletion size in chromosome 22q11.2 deletion syndrome

The clinical features of 22q11.2 deletion syndrome include virtually every organ of the body. This review will focus on the immune system and the differences related to deletion breakpoints. A hypoplastic thymus was one of the first features described in this syndrome and low T cell counts, as a consequence of thymic hypoplasia, are the most commonly described immunologic feature. These are most prominently seen in early childhood and can be associated with increased persistence of viruses. Later in life, evidence of T cell exhaustion may be seen and secondary deficiencies of antibody function have been described. The relationship of the immunodeficiency to the deletion breakpoints has been understudied due to the infrequent analysis of people carrying smaller deletions. This manuscript will review the immune deficiency in 22q11.2 deletion syndrome and describe differences in the T cell counts related to the deletion breakpoints. Distal, non‐TBX1 inclusive deletions, were found to be associated with better T cell counts. Another new finding is the relative preservation of T cell counts in those patients with a 22q11.2 duplication.
The interaction between vitamin A and thiazolidinedione on bovine adipocyte differentiation in primary culture.

We studied the effects of a thiazolidinedione (T-174) and retinoids on adipocyte differentiation in beef cattle. Stromal-vascular (SV) cells containing preadipocytes were prepared from perirenal adipose tissue of 21-mo-old Japanese Black steers. After confluence, these cells were cultured in 25 microM T-174, which is a specific ligand for an adipogenesis stimulating nuclear receptor (i.e., gamma subtype of peroxisome proliferator-activated receptor [PPARgamma]), with 1 microM all-trans retinoic acid (RA) or . 4 to 40 microg/100 mL of retinol for 10 to 14 d. The number of cells accumulating lipid droplets was counted as morphologically differentiated adipocytes, and the activity of glycerol-3-phosphate dehydrogenase (GPDH), a biochemical index for the differentiation, was determined. The number of lipid-laden cells and GPDH activity were increased by the addition of T-174. All-trans retinoic acid completely blocked the stimulative action of T-174. The addition of retinol also decreased the number of lipid-laden cells and GPDH activity in a dose-dependent manner. These results showed that the thiazolidinedione stimulated adipocyte differentiation and the retinoids blocked the adipogenesis induced by the thiazolidinedione in primary culture of bovine SV cells. Peroxisome proliferator-activated receptor gamma may play an important role in adipocyte differentiation, and retinoids may interfere with the action of PPARgamma in cattle.
KELEMAHAN UNDANG-UNDANG MEREK DALAM HAL PENDAFTARAN MEREK (Studi Atas Putusan Sengketa Merek Pierre Cardn)

Abstract This legal research examines the weakness of Act No. 20 of 2016 on Marks and Geographical Indications, as until now there is still a knockoff brands that passed trademark registration in Indonesia. This research uses doctrinal or normative prescriptive research methods. Results of this study is the absence of the requirements and there are multiple interpretations of the philosophy of the brand famous brand understanding and similarity in principle or in its entirety. Keyword: Trademark registration, weakness of Act Abstrak Penulisan hukum ini mengkaji mengenai kelemahan Undang-Undang Nomor 20 Tahun 2016 tentang Merek dan Indikasi Geografis sebagaimana sampai sekarang ini masih terdapat merek-merek tiruan yang lolos pendaftaran merek di Indonesia. Penulisan ini menggunakan metode penelitian doktrinal atau normatif yang bersifat preskriptif. Hasil penelitian ini adalah tidak adanya persyaratan filosofi merek dan terdapat multitafsir pemahaman merek terkenal dan persamaan pada pokoknya atau keseluruhannya. Kata kunci: pendaftaran merek, kelemahan UU
Expression of CD66a in multiple myeloma

CD66a is a member of the carcinoembryonic antigen family and has been suggested to function as an intercellular adhesion molecule and cell growth regulator. Expression of CD66a in myeloma cells was examined with mAb TS135 against CD66a transfectants of murine‐transformed fibroblasts. The reactivity of mAb TS135 with CD66a, CD66c, and CD66e was revealed. CD66a in myeloma cells was considered to be detectable with this mAb, since CD66c and CD66e are not expressed in them. CD66a was detected in three myeloma cell lines and an IgM‐producing B‐cell line. In clinical bone marrow specimens, including 18 multiple myeloma, two primary macroglobulinemia, and a case of CLL‐like chronic lymphoproliferation with monoclonal IgG production, CD66a and three conventional myeloma cell markers (PCA‐1, CD38, and CD56) were examined by indirect immunofluorescence assay. The results showed that 18 out of 21 cases (86%) were CD66a+, and PCA‐1 showed the highest correlation with CD66a among conventional markers. Primary macroglobulinemia and chronic lymphoproliferation were also CD66a+. Two‐dimensional flow cytometry with mAbs TS135 and CD38 confirmed the reactivity of TS135 with myeloma cells in those bone marrow specimens. The findings suggest that CD66a is expressed in multiple myeloma with high frequency. J. Clin. Lab. Anal. 16:79–85, 2002. © 2002 Wiley‐Liss, Inc.
Survey of the bp/tee genes from clinical group A streptococcus isolates in New Zealand - implications for vaccine development.

Group A streptococcus (GAS) is responsible for a wide range of diseases ranging from superficial infections, such as pharyngitis and impetigo, to life-threatening diseases, such as toxic shock syndrome and acute rheumatic fever (ARF). GAS pili are hair-like extensions protruding from the cell surface and consist of highly immunogenic structural proteins: the backbone pilin (BP) and one or two accessory pilins (AP1 and AP2). The protease-resistant BP builds the pilus shaft and has been recognized as the T-antigen, which forms the basis of a major serological typing scheme that is often used as a supplement to M typing. A previous sequence analysis of the bp gene (tee gene) in 39 GAS isolates revealed 15 different bp/tee types. In this study, we sequenced the bp/tee gene from 100 GAS isolates obtained from patients with pharyngitis, ARF or invasive disease in New Zealand. We found 20 new bp/tee alleles and four new bp/tee types/subtypes. No association between bp/tee type and clinical outcome was observed. We confirmed earlier reports that the emm type and tee type are associated strongly, but we also found exceptions, where multiple tee types could be found in certain M/emm type strains, such as M/emm89. We also reported, for the first time, the existence of a chimeric bp/tee allele, which was assigned into a new subclade (bp/tee3.1). A strong sequence conservation of the bp/tee gene was observed within the individual bp/tee types/subtypes (>97 % sequence identity), as well as between historical and contemporary New Zealand and international GAS strains. This temporal and geographical sequence stability provided further evidence for the potential use of the BP/T-antigen as a vaccine target.
Are anxiety and depressed mood related to physical symptom burden? A study in hospitalized advanced cancer patients

Background : Anxiety and depressed mood are common symptoms in hospitalized advanced cancer patients. It is often presumed that anxiety and depression affect the occurrence and experience of physical symptoms. Purpose : To analyse the relation between anxiety, depressed mood and the presence and intensity of physical symptoms. Patients and methods : Anxiety and depressed mood were assessed in a hospitalized advanced cancer population (n = 79) primarily by the Hospital Anxiety and Depression Scale (HADS), and also by a single-item question `Are you anxious and/or depressed? ' and by the Edmonton Symptom Assessment System (ESAS). Physical symptoms were assessed by a semi-structured interview and by the ESAS. Results : Thirty-four percent of the patients reported anxiety, 56% depressed mood and 29% both, as assessed by the HADS. The correlations between HADS, the single-item question and the ESAS were low. No association was found between anxiety or depressed mood and the presence of physical symptoms. Patients who were anxious or depressed had higher ESAS scores for insomnia and drowsiness; scores for pain, anorexia, asthenia, nausea and dyspnea were independent of anxiety and/or depressed mood. Conclusion : The relationship between anxiety, depressed mood and the presence and intensity of physical symptoms in hospitalized advanced cancer patients is very limited. Palliative Medicine 2007; 21: 341—346
Stress and the General Adaptation Syndrome*

With the concept of the general adaptation syndrome we have attempted to integrate a number of seemingly quite unrelated observations into a single unified biologic system. I would draw attention briefly to the work of Claude Bernard, who showed how important it is to maintain the constancy of the "milieu interieur" ; Cannon's concept of " homoeostasis "; Frank Hartmann's " general tissue hormone" theory of the corticoids; Dustin's observations on the " caryoclastic poisons," the " post-operative disease," the curative action of fever, foreign proteins, and of other " non-specific therapeutic agents "; the " nephrotoxic sera " of Masugi; and to the " Goldblatt clamp" for the production of experimental renal hypertension. At first sight it would seem that all these observations have little in common and that there is no reason to attempt their integration into a unified system of physiological and pathological events. Yet most of my research work has been devoted to the construction of bridges between these and many additional facts, since they were thought to be interconnected in nature. Through the comprehension of their unity we hoped to learn how to use them better for the understanding of life and the treatment of disease. The keynote of this unification was the tenet that all living organisms can respond to stress as such, and thiat in this respect the basic reaction pattern is always the same, irrespective of the agent used to produce stress. We called this response the general adaptation syndrome, and its derailments the diseases of adaptation. Anything that causes stress endangers life, unless it is met by adequate adaptive responses; conversely, anything that endangers life causes stress and adaptive responses. Adaptability and resistance to stress are fundamental prerequisites for life, and every vital organ and function participates in them. In order to present a well-proportioned outline of the general adaptation syndrome it was necessary, therefore, to peruse every branch of physiology, biochemistry, pathological anatomy, and clinical medicine in search of the "stress factor" in all aspects of normal and abnormal life. It will take many years, indeed many generations, before the details of the general adaptation syndrome are satis-
A Historical Perspective on SIDS Research

To put research concerned with the sudden infant death syndrome (SIDS) into perspective, it is essential to consider the nature of this problem. Unlike other, more tractable, medical conditions there are usually no obvious clues from the infants that something is awry before they are found dead. As with a mystery novel, the investigator is faced with a victim and must search for clues that will lead to a solution. From the earliest efforts to solve the riddle of SIDS, investigators, who were few in number, sought to make sense of what they found during postmortem examinations. In the late 1700s through the late 1800s it was believed that an enlarged thymus pressed on the trachea cutting off the airway or the blood supply to the head. I As support for the thymic theory waned, the idea that SIDS infants had been “uverlaid” or “stifled in bed,” a theory which had never really been fully rejected, was again embraced by the medical profession and lay public. Even Templeman,’ a Scottish medical examiner, whose description in 1892 of 258 cases of “suffocation” of infants bears a striking resemblance to postmortem and epidemiological descriptions of SIDS infants today, believed that these deaths by suffocation were due to ignorance, carelessness, drunkenness, and overcrowding among the lower classes. Templeman’s report that the greatest number of cases occurred between October and March and the highest incidence was among infants of poor socioeconomic circumstances who were between one and six months of age is consistent with epidemiological findings dating back several decades. An important difference is that it is quite clear that SIDS occurs in all socioeconomic groups, although, as with other medical problems, it is the poor who suffer the most. The observations of infants at autopsy by Werne and Garrow’-’ in the 1940s produced the first evidence that in many sudden and unexpected infant death cases, the cause of death appeared to be from natural causes, possibly involving an inflammatory response, and not suffocation. The observations of various investigators regarding seasonality, inflammation, frequent histories of a slight, upper respiratory infection prior to death, and essentially negative necropsy findings prompted the search in the 1960s for a viral etiology for SIDS. With its establishment, the National Institute of Child Health and Human Development (NICHD) sought to stimulate interest in scientific studies by holding a research conference in 1963 at Seattle, Washington.6 It was expected that the exchange of ideas during this conference would encourage research grant applications from the scientific community, but this did not occur. By 1969, NICHD was supporting only two projects that had SIDS as a primary focus. A second NICHD-sponsored research conference’ in Seattle, in 1969, expanded the
Design of CPW Lange Couplers in Multi-Layer Thin-Film MCM-D

Three procedures (method of Ou, Paolino and Kajfez) for the design of CPW Lange couplers are compared for the first time. For each method, the couplers geometry is determined using a quasi-TEM program and verified by full electromagnetic simulations. The couplers are finally fabricated in a multilayer thin-film MCM-D process. The method of Paolino gives the best results. In the 10.8-14.9 GHz band, we have obtained a return loss below ¿18 dB, isolation below ¿20 dB, an amplitude balance below 0.2 dB and a phase balance of (90.7+/¿0.9) deg. An excellent correspondence between measurement and simulations has been obtained.
Differentiation of a human neuroblastoma into neuron‐like cells increases their susceptibility to transduction by herpesviral vectors

Gene transfer is a powerful tool for functional gene analysis in human cells. In this respect, there is a need to develop experimental models that involve homogeneous cultures of human neuron‐like cells susceptible to gene transduction and that are easy to handle. Here we describe an optimized and reproducible procedure to differentiate human SH‐SY5Y neuroblastoma cells into a homogeneous population of neuron‐like cells. The fully differentiated cells are postmitotic and resemble primary cultured neurons in terms of their cytoskeletal polarity. Notably, differentiated SH‐SY5Y cells are far more susceptible to transduction by herpes simplex virus (HSV‐1)‐based vectors than proliferating SH‐SY5Y cells. This increase in transduction efficiency after neuronal differentiation may be due to the up‐regulation of cell surface receptors for herpesvirus entry. In summary, we propose that fully differentiated human neuron‐like cells obtained from the SH‐SY5Y neuroblastoma may constitute an excellent and versatile experimental tool for gene transfer and functional genomic studies with HSV‐1 vectors. © 2006 Wiley‐Liss, Inc.
Effects of Green Tea and EGCG on Cardiovascular and Metabolic Health

Since ancient times green tea has been considered a health-promoting beverage. In recent years, scientists throughout the world have investigated the potential benefits of green tea and its most abundant catechin, epigallocatechin gallate (EGCG). The anti-cancer effects of green tea and EGCG were the focus of early research, and encouraging data from in vitro, animal model, and human studies have emerged. Due to the dominant role of cardiovascular disease and the dramatic rise of obesity and type 2 diabetes mellitus as major and interlinked healthcare problems, green tea and EGCG are increasingly being investigated in these areas. Dose-response relationships observed in several epidemiological studies have indicated that pronounced cardiovascular and metabolic health benefits can be obtained by regular consumption of 5–6 or more cups of green tea per day. Furthermore, intervention studies using similar amounts of green tea, containing 200–300 mg of EGCG, have demonstrated its usefulness for maintaining cardiovascular and metabolic health. Additionally, there are numerous in vivo studies demonstrating that green tea and EGCG exert cardiovascular and metabolic benefits in these model systems. Therefore, green tea and EGCG can be regarded as food components useful for the maintenance of cardiovascular and metabolic health. To prove the effectiveness for disease prevention or treatment, several multi-center, long-term clinical studies investigating the effects of one precisely-defined green tea product on cardiovascular and metabolic endpoints would be necessary. The aim of this manuscript is to provide an overview of the research investigating the effects of green tea and green tea catechins on cardiovascular and metabolic health.
ANALISIS TINGKAT LITERASI KEUANGAN DAN PENGARUHNYA TERHADAP PERILAKU KEUANGAN PADA MAHASISWA PRODI MANAJEMEN UNIVERSITAS TERBUKA

Tujuan dari penelitian ini adalah mengkaji dan menganalisis tingkat literasi keuangan dan pengaruhnya terhadap perilaku keuangan pada mahasiswa Prodi Manajemen universitas Terbuka. Sampel dalam penelitian ini berjumlah 500 mahasiswa Prodi Manajemen Universitas Terbuka. Data dianalisis menggunakan metode Partial Least Square (PLS) dan menggunakan tools SmartPLS. Hasil dari penelitian ini adalah nilai signifikasi terbesar pada variabel literasi keuangan pada mahasiswa Prodi Manajemen Universitas Terbuka adalah memiliki tabungan yang cukup untuk pengeluaran tidak terduga. Nilai t-statistik pengaruh literasi keuangan terhadap perilaku keuangan sebesar 46.011197, nilai ini lebih besar dari nilai t-tabel 1.98 untuk level signifikan 0.05 (5%) yang menunjukkan signifikansi pengaruh antar variabel laten. Nilai R-square untuk variabel laten Keputusan Berkunjung didapatkan nilai sebesar 0.598824, hal ini menunjukkan bahwa variabel literasi keuangan berpengaruh sebesar 59.8824% terhadap perilaku keuangan. Sedangkan sisanya dijelaskan oleh variabel lain yang tidak termasuk dalam penelitian ini. Implikasi dari penelitian ini ditunjukkan bagi para mahasiswa Prodi Manajemen Universitas Terbuka agar mereka memiliki pengetahuan tentang keuangan sejak dini, agar mereka dapat menjadi manusia cerdas yang dapat mengatur keuangan dengan baik sehingga tidak mengalami kesulitan keuangan dimasa depan.