Miracle-dz/UniFAR-FTUs huggingface dataset:
Environmental Determinants of the Distribution and Abundance of the Ants, Lasiophanes picinus and L. valdiviensis, in Argentina

Abstract The distribution and abundance variation of the terrestrial ants, Lasiophanes picinus and Lasiophanes valdiviensis Emery (Formicinae: Lasiini), which are endemic in Patagonia (Argentina and Chile), are described and a set of environmental factors are examined to explain the observed patterns. Ants were collected using 450 pitfall traps arranged in 50, 100 m2 grid plots each with nine traps within a roughly 150 × 150 km area representative of the subantartic-patagonian transition of Argentina. Five sampling periods each 8-days long were carried out between November 2004 and March 2006. To understand the distributional patterns and their link to environmental variables discriminant analysis was used. Path analysis was performed to test for direct and indirect effects of a set of environmental variables on species abundance variation. L. picinus was more frequently captured and attained higher abundance in the forests, while L. valdiviensis was more frequently captured and more abundant in the scrubs. The maximum daily temperature and mean annual precipitation explained L. picinus distribution (i.e. presence or absence) with an accuracy of 90%. L. valdiviensis distribution was predicted with almost 70% accuracy, taking into account herbal richness. The maximum daily temperature was the only climatic variable that affected ant abundance directly; an increase in temperature led to an increase of L. picinus abundance and a decrease of L. valdiviensis abundance. The amount of resources, as indicated by the percent plant cover, explained the variation of the abundance of both species better than the variety of resources as indicated by plant richness (i.e. models including plant richness had low fit or no fit at all). A direct effect of habitat use by cattle was found, as indicated by the amount of feces in the plots, only when variables related to the amount of resources were replaced by variables with less explanatory power related to the variety of resources. This study provides new data on the ecology of Lasiophanes species in relation to existing hypotheses proposed to explain patterns of abundance variation. Evidence is provided that changes in temperature (i.e. global climate change) may have important consequences on populations of these species.
Skin Capillary Density in Subjects with Impaired Glucose Tolerance and Patients with Type 2 Diabetes

In view of recent interest in the role of impaired early development and the pathogenesis of cardiovascular disease and carbohydrate intolerance in adults, this study examines whether reduced skin capillary density contributes to the limited microvascular hyperaemic responses observed in patients with Type 2 diabetes and subjects with impaired glucose tolerance (IGT). Fifteen patients with Type 2 diabetes, 15 subjects with IGT and 15 matched non‐diabetic control subjects were studied. Capillary videomicroscopy was used to record images of the skin capillaries on the dorsum of the middle phalanx of the left middle finger before and after 10 min venous occlusion at 35 mmHg. There were no significant differences between the three groups in either basal capillary density (112 (71–144) caps mm−2 Type 2 patients (median and range) vs 107 (76–140) caps mm−2 IGT subjects vs 112(76–138) caps mm−2 control subjects; p = 0.9, Kruskal Wallis), or following venous occlusion (122(87–157) caps mm−2 vs 121 (90–143) caps mm−2 vs 123 (81–147) caps mm−1; p=0.9). In addition there were no differences in blood pressure, BMI or skin temperature. These results do not support the concept of impaired early development of the skin microcirculation in patients with Type 2 diabetes or IGT and suggest that mechanisms other than reduced capillary density are involved in limiting microvascular vasodilation.
Evaluation of reproductive toxicity in male rats treated with novel synthesized ruthenium(II) and gold(I)-NHC complexes

In this study, we aimed to determine the reproductive toxicity in rat induced by ruthenium(II)-NHC (RuII) and gold(I)-NHC (AuI) complexes that have anticarcinogenic effects. For this purpose, 35 Sprague–Dawley rats were randomly divided into 5 equal groups. In control group, rats treated with saline, RuII, and AuI complexes were intraperitoneally given high (10 mg/kg) and low (5 mg/kg) doses to rats via a one-time administration. The animals were sacrificed, and testis tissues were taken on Day 10 of the drug administration for the determination of the biochemical, histopathological, spermatological, and hormonal parameters. It was determined that treatment group that was subjected to treatment using both RuII and AuI complexes significantly caused oxidative, histopathological, spermatological, and hormonal damage compared to control group. However, the sexual and accessory organ weight did not significantly change when compared to control. In addition, it was shown that AuI treatment generally caused more adverse effects than RuII treatment in a dose-dependent manner. In conclusion, when these synthesized compounds are used for the treatment of cancer, they could cause toxic effects on male reproductive system and lead to infertility. However, RuII complex is a more preferable option in cancer treatment, particularly in terms of user safety.
Fiscal Sustainability and the Financial Cycle

A frequently neglected aspect of financial booms and busts - financial cycles - is their impact on fiscal positions. And yet, the latest financial crisis and history show that these cycles can wreak havoc with public finances. After reviewing the impact of financial cycles on fiscal positions, we offer a new tool to estimate cyclically adjusted balances, illustrate its performance, explore its strengths and weaknesses, and sketch out a way forward to measuring sustainability in a more holistic way.
FOOD INSECURITY AND PROGRAMS TO ALLEVIATE IT: WHAT WE KNOW AND WHAT WE HAVE YET TO LEARN

Abstract Fourteen percent of households in the United States faced some level of food insecurity in 2014. This study provides a review of the state of knowledge on food insecurity in the United States and the programs designed to combat the problem. A household decision-making model is used to frame the discussion. The study also provides suggestions for future research.
Effects of the serotonin transporter polymorphism and history of major depression on overgeneral autobiographical memory

Overgeneral autobiographical memory (OGM) is a key memory deficit in major depressive disorder (MDD). Much research has examined cognitive mechanisms underlying OGM, but little work has investigated potential neurobiological influences. There is preliminary evidence that a genetic serotonergic vulnerability coupled with depressive symptoms may be associated with other memory impairments, and experimental research suggests a role for serotonin in OGM. We investigated whether a polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) was associated with OGM in interaction with a lifetime history of MDD in 370 young adults in a longitudinal study of risk for emotional disorders. There was a significant interaction between 5-HTTLPR genotype and lifetime history of MDD in predicting OGM. Among S allele homozygotes, MDD history was associated with greater OGM, whereas no significant relationship between MDD history and OGM emerged among L carriers. Furthermore, there was evidence that a greater number of S alleles were associated with greater memory specificity in individuals without a history of MDD. Implications for understanding cognitive and biological risk for depression are discussed.
Morphometrical Analysis of Developing Cochlear Ganglion Neurons: A Light Microscopic Fetal Study.

BACKGROUND AND AIM The cochlear or spiral ganglion neurons are the initial bridge between the external world of sound and its discernment in the brain. As the developing human fetal cochlea is known to start functioning in mid gestational period, its anatomical details when compared with adults could vary with each gestational age. The aim of current study was to assess morphometrical parameter of developing human fetal cochlear ganglion neurons and comparison of data in each gestational period. MATERIALS AND METHODS Ten aborted human fetuses from 14th to 28th weeks of gestation were procured from Department of Obstetrics and Gynaecology of associated hospital, after obtaining ethical clearance and were processed for studying under light microscope. Area of neurons from each gestational age was measured on histophotomicrographs using image Proplus software. Standard statistical method was used to calculate area range and percentage of small and large ganglion neurons. RESULTS The neuronal area increased progressively in successively higher gestation age fetuses. In the fetus belonging to lowest gestational age the area ranged from 4-37μm2 while in highest gestational age fetus its range was 10-58. 3μm2. The small ganglion neurons were higher in 14 weeks (65.5%) fetuses and 16-20 weeks (81.03%) fetuses, while in higher gestational age fetuses' large ganglion neuronal population was higher (62-66%). CONCLUSION A baseline morphometrical representation of fetal cochlear ganglion neurons could be of relevance in advanced human experimental studies on effect of neurotrophic factors in human fetuses with congenital deafness. It has been found that these factors directly influence neuronal maturation assessed by progressive increase in soma size and survival.
Evidence of Multiple Regulatory Functions for the PtsN (IIANtr) Protein of Pseudomonas putida

ABSTRACT The ptsN gene of Pseudomonas putida encodes IIANtr, a protein of the phosphoenol pyruvate:sugar phosphotransferase (PTS) system which is required for the C source inhibition of the ς54-dependent promoter Puof the TOL (toluate degradation) plasmid pWW0. Using two-dimensional gel electrophoresis, we have examined the effect of ptsNdisruption on the general expression pattern of P. putida. To this end, cells were grown in the presence or absence of glucose, and a 1,117-spot subset of the P. putida proteome was used as a reference for comparisons. Among all gene products whose expression was lowered by this carbon source (247 spots [about 22%]), only 6 behaved as Pu (i.e., were depressed in theptsN background). This evidenced only a minor role for IIANtr in the extensive inhibition of gene expression inP. putida caused by glucose. However, the same experiments revealed a large incidence of glucose-independent effects brought about by the ptsN mutation. As many as 108 spots (ca. 9% of the cell products analyzed) were influenced, positively or negatively, by the loss of IIANtr. By matching this pattern with that of an rpoN::ΩKm strain of P. putida, which lacks the ς54 protein, we judge that most proteins whose expression was affected by ptsN were unrelated to the alternative sigma factor. These data suggest a role of IIANtr as a general regulator, independent of the presence of repressive carbon sources and not limited to ς54-dependent genes.
Straddling Cultures, Identities, and Inconsistencies: Voices of Pre-Tenure Faculty of Color in Educational Leadership

Drawing on the notions of biculturalism, or double consciousness, and hybridity, this qualitative study explored how 12 pre-tenure faculty of color (FOC) in the field of educational leadership working at universities in the United States negotiated their self-identified cultural identities within their predominantly White departments. Results indicated that participants were more bicultural in nature than they were in self-authoring a new hybrid identity. Nonetheless, bicultural skills equipped FOC with a better sense of how to help their departments critically examine and move beyond White-dominant notions of educational leadership preparation to more culturally responsive approaches.
Fate of a Burkholderia pseudomallei Lipopolysaccharide Mutant in the Mouse Macrophage Cell Line RAW 264.7: Possible Role for the O-Antigenic Polysaccharide Moiety of Lipopolysaccharide in Internalization and Intracellular Survival

ABSTRACT Burkholderia pseudomallei is a facultative intracellular gram-negative bacterium that can survive and multiply inside macrophages. One of the mechanisms by which B. pseudomallei escapes macrophage killing is by interfering with the expression of inducible nitric oxide synthase (iNOS). However, the bacterial components that modulate antimicrobial activity of the macrophage have not been fully elucidated. In the present study, we demonstrated that B. pseudomallei strain SRM117, a lipopolysaccharide (LPS) mutant that lacks the O-antigenic polysaccharide moiety, was more susceptible to macrophage killing during the early phase of infection than the parental wild-type strain (1026b). Unlike the wild type, the LPS mutant could readily stimulate Y701-STAT-1 phosphorylation (pY701-STAT-1) and interferon-regulatory factor 1 (IRF-1) expression, both of which are essential transcription factors of iNOS. Neutralizing antibody against beta interferon was able to inhibit the phosphorylation of Y701-STAT-1 and the expression of IRF-1 and iNOS, all of which resulted in an increased rate of intracellular replication. These data suggest that the O-antigenic polysaccharide moiety of B. pseudomallei modulates the host cell response, which in turn controls the intracellular fate of B. pseudomallei inside macrophages.
Superposition Violations in the Compensatory Eye Movement System.

PURPOSE Compensatory eye movements (CEM) maintain a stable image on the retina by minimizing retinal slip. The optokinetic reflex (OKR) and vestibulo-ocular reflex (VOR) compensate for low and high velocity stimuli, respectively. The OKR system is known to be highly nonlinear. The VOR is generally modeled as a linear system and assumed to satisfy the superposition and homogeneity principles. To probe CEM violation of the superposition principle, we recorded eye movement responses in C57BL/6 mice to sum of sine (SoS) stimulation, a combination of multiple nonharmonic inputs. METHODS We tested the VOR, OKR, VVOR (visually enhanced VOR), and SVOR (suppressed VOR). We used stimuli containing 0.6 Hz, 0.8 Hz, 1.0 Hz, and 1.9 Hz. Power spectra of SoS stimuli did not yield distortion products. Gains and delays of SoS and single sine (SS) responses were compared to yield relative gains and delays. RESULTS We find the superposition principle is violated primarily in the OKR, VOR, and SVOR conditions. In OKR, we observed relative gain suppression of the lower SoS stimulus frequency component irrespective of the absolute frequency. Conversely, SVOR and VOR results showed gain enhancement of the lower frequency component and overall decrease in lead. Visually enhanced VOR results showed trends for overall gain suppression and delay decrease. CONCLUSIONS Compensatory eye movements arguably depend on predictive signals. These results may reflect better prediction for SS stimuli. Natural CEM system stimulation generally involves complex frequency spectra. Use of SoS stimuli is a step toward unravelling the signals that really drive CEM and the predictive algorithms they depend on.
Gait pattern of severely disabled hemiparetic subjects on a new controlled gait trainer as compared to assisted treadmill walking with partial body weight support

Objectives: To investigate to what extent and with how much therapeutic effort nonambulatory stroke patients could train a gait-like movement on a newly developed, machine-supported gait trainer. Design: Open study comparing the movement on the gait trainer with assisted walking on the treadmill. Setting: Motion analysis laboratory of a rehabilitation centre. Subjects: Fourteen chronic, nonambulatory hemiparetic patients. Intervention: Complex gait analysis while training on the gait trainer and while walking on the treadmill. Main outcome measures: Gait kinematics, kinesiological EMG of several lower limb muscles and the required assistance. Results: Patients could train a gait-like movement on the gait trainer, characterized kinematically by a perfect symmetry, larger hip extension during stance, less knee flexion and less ankle plantar flexion during swing as compared to treadmill walking (p <0.01). The pattern and amount of activation of relevant weight-bearing muscles was comparable with an even larger activation of the M. biceps femoris on the gait trainer (p <0.01). The tibialis anterior muscle of the nonaffected side, however, was less activated during swing (p <0.01). Two therapists assisted walking on the treadmill while only one therapist was necessary to help with weight shifting on the new device. Conclusion: The newly developed gait trainer offered severely disabled hemiparetic subjects the possibility of training a gait-like, highly symmetrical movement with a favourable facilitation of relevant anti-gravity muscles. At the same time, the effort required of the therapists was reduced.
Genotypic versus phenotypic characterization, with respect to susceptibility and identification, of 17 clinical isolates of Staphylococcus lugdunensis.

OBJECTIVES To compare different methods for the identification and determination of susceptibility to penicillin and methicillin of Staphylococcus lugdunensis. METHODS Seventeen clinical isolates of S. lugdunensis (identified by PCR amplification and sequencing of the rpoB gene) were studied using the ATB32-Staph, Crystal, Vitek 2 and Wider commercial systems. The clumping factor test and the tube coagulase test were also performed. Beta-lactamase production was studied by chromogenic methods. Methicillin resistance was phenotypically studied by the MRSA slide latex agglutination test, growth in MRSA agar, and the Vitek 2 and Wider systems (based on oxacillin MIC), and genotypically studied by detection of the mecA gene by PCR. RESULTS The clumping factor test was negative in 35.3% of strains. All isolates were correctly identified to species level by the ATB32-Staph system. Species misidentification rates were 5.9%, 23.5% and 29.4% with the Crystal, the Vitek 2 and the Wider systems, respectively, mostly as Staphylococcus haemolyticus. Beta-lactamase was present in 11.8% of strains. Whereas 76.5% and 47.1% of strains exhibited oxacillin resistance (MIC range 0.5-2 mg/L) by the Vitek 2 system and the Wider system, respectively, none of the strains was positive in the MRSA slide latex agglutination test or grew in MRSA agar. All strains lacked the mecA gene. CONCLUSIONS The clumping factor test and some commercial systems may misidentify S. lugdunensis. Oxacillin resistance detected by commercial systems is not indicative of the presence of the mecA gene. These facts, together with beta-lactamase production, may preclude adequate treatment of infections by this virulent coagulase-negative Staphylococcus.
What Determines the DPRK's Anthracite Exports to China?: Implications for the DPRK's Economy.

Anthracite exports have special value within the DPRK’s economy. In this paper, we focus on what determines the DPRK’s anthracite exports to China. We use panel data consisting of cross-section data from 30 provinces in China and quarterly time-series data from 1998 to 2013. Controlling for all other variables that affect anthracite imports, the variable for steel production in China is robust and statistically significant. This is consistent with on-site interviews which indicate that much of North Korean anthracite is consumed by China’s steel industry. This implies that the North Korean authorities need to make adjustments to the foreign trade structure, as the import demand for anthracite in China may decline further.
A Survey on Non-Orthogonal Multiple Access for 5G Networks: Research Challenges and Future Trends

Non-orthogonal multiple access (NOMA) is an essential enabling technology for the fifth-generation (5G) wireless networks to meet the heterogeneous demands on low latency, high reliability, massive connectivity, improved fairness, and high throughput. The key idea behind NOMA is to serve multiple users in the same resource block, such as a time slot, subcarrier, or spreading code. The NOMA principle is a general framework, and several recently proposed 5G multiple access schemes can be viewed as special cases. This survey provides an overview of the latest NOMA research and innovations as well as their applications. Thereby, the papers published in this special issue are put into the context of the existing literature. Future research challenges regarding NOMA in 5G and beyond are also discussed.
Contribution of nitric oxide to the endothelium‐dependent hyperpolarization in rat aorta.

1. The effect of endogenous and exogenous nitric oxide on the membrane potential (Em) of smooth muscle cells of the thoracic aorta of rats was investigated. 2. In tissues with intact endothelium, application of ACh or carbachol generated a change of the membrane potential consisting of an initial hyperpolarization by 10‐12 mV, followed by a partial recovery toward a level which was at 10 min still 6‐8 mV more negative than in control conditions. 3. Application of NG‐nitro‐L‐arginine methylester (L‐NAME), an inhibitor of endogenous NO production, had no significant effect on the resting membrane potential. The initial peak endothelium‐dependent hyperpolarization elicited by ACh or carbachol was not significantly diminished. However, the recovery was more accentuated. Similarly, NG‐monomethyl‐L‐arginine (L‐NMMA) significantly diminished the second component of the endothelium‐dependent hyperpolarization without affecting the magnitude of the first transient peak Em change. 4. Nitroglycerin produced a small sustained hyperpolarization of 1‐2 mV, and the NO donor SIN‐1, the active metabolite of molsidomine, similarly increased Em by about 1 mV. Infusion of high doses of acidified NaNO2 solution caused a hyperpolarization smaller than that evoked by ACh or carbachol. 5. 8‐Bromo‐cyclic GMP caused little change of membrane potential. In the presence of 8‐Br‐cGMP, ACh evoked a membrane electrical response similar to that observed in the absence of the nucleotide. 6. It is concluded that, in the rat aorta, the initial peak endothelium‐dependent hyperpolarization observed under the influence of ACh or carbachol is not directly related to the synthesis of NO.(ABSTRACT TRUNCATED AT 250 WORDS)