Miracle-dz/UniFAR-FTUs huggingface dataset:
The Relationship Between Blood Pressure and Pain

The relationship between pain and hypertension is potentially of great pathophysiological and clinical interest, but is poorly understood. The perception of acute pain initially plays an adaptive role, which results in the prevention of tissue damage. The consequence of ascending nociception is the recruitment of segmental spinal reflexes through the physiological neuronal connections. In proportion to the magnitude and duration of the stimulus, these spinal reflexes cause the activation of the sympathetic nervous system, which increases peripheral resistances, heart rate, and stroke volume. The response also involves the neuroendocrine system, and, in particular, the hypothalamic‐pituitary‐adrenal axis, in addition to further activation of the sympathetic system by adrenal glands. However, in proportion to an elevation in resting blood pressure, there is a contemporary and progressive reduction in sensitivity to acute pain, which could result in a tendency to restore arousal levels in the presence of painful stimuli. The pathophysiological pattern is significantly different in the setting of chronic pain, in which the adaptive relationship between blood pressure and pain sensitivity is substantially reversed. The connection between acute or chronic pain and cardiovascular changes is supported observationally, but some of this indirect evidence is confirmed by experimental models and human studies. The pain regulatory process and functional interaction between cardiovascular and pain regulatory systems are briefly reviewed. Various data obtained are described, together with their potential clinical implications.
Contribution of the Bindura community share ownership trust to rural development in Bindura rural district council of Zimbabwe

This research analysed the contribution of the Bindura Community Share Ownership Trust (BCSOT) to Bindura Rural District Council (BRDC) in Mashonaland Central Province of Zimbabwe. Key informant interviews and the survey questionnaire were used for primary data collection while secondary sources such as the Indigenisation and Economic Empowerment Act of 2007 and Statutory Instrument of 2010 which established the Community Share Ownership Trusts were analysed. The research found that 45 projects had been embarked on by the BCSOT. These projects included water, health, education and roads. It concludes that these projects had greatly contributed to rural development in Bindura Rural District Council. The respondents indicated that if CSOTs are to succeed, there should local community involvement in the identification of projects. The research recommended that the BCSOT should also establish small to medium enterprises and other income-generating projects in order to improve rural livelihoods.
Quantitative MRI findings and cognitive impairment among community dwelling elderly subjects

Objectives: To study the factors which influence cognitive impairment among elderly subjects living in a local community, based on both MRI and clinical findings, to further elucidate the causes of dementia, and also to help develop strategies for its prevention. Methods: Cranial MRI and other medical examinations were performed on non-demented elderly subjects who resided in one rural community. A total of 254 subjects aged from 60 to 91 years of age, with a mean age of 73.9 (SD 6.8) were examined. The mini mental state examination (MMSE) was used to identify cognitive impairment. White matter lesions and cerebral atrophy on MR images were measured quantitatively. A multivariate analysis was also performed with the existence of cognitive impairment as the dependent variable, and the MRI findings and clinical observations were used as the independent variables. Results: Cognitive impairment was present in 46 subjects (18.1%). They were older, had a lower educational level, and more frequent hypertension compared with those without cognitive impairment. The packed cell volume was lower in the impaired group. In addition, their MRI findings showed significantly larger quantities of white matter lesions and cerebral atrophy, as well as more infarcts. A logistic regression analysis demonstrated a significant relation among such factors as white matter lesions (odds ratio (OR) 1.575, 95% confidence interval (95% CI) 1.123–2.208), cerebral atrophy (OR 0.761, 95%CI 0.587–0.987), and lower education (OR 0.682, 95%CI 0.544–0.855) for subjects with a cognitive impairment. Conclusions: White matter lesions and cerebral atrophy are factors which induce a cognitive impairment in community dwelling elderly subjects without dementia. It is important to carefully watch for any abnormalities in these factors, and to perform cohort studies to check for the above risk factors, to both prevent and make an early diagnosis of dementia.
Constraints in acquiring and utilizing directors' experience: An empirical study of new‐market entry in the pharmaceutical industry

In this study we provide evidence that firms considering entering new markets are more likely to appoint directors with experience in those markets; and subsequently, we show that directors' market experience increases the likelihood of new-market entry. Moreover, we explore the presence of constraints in both, acquiring experienced directors and utilizing their experience. Specifically, we find that experienced directors are less likely to join firms with financial restatements in the recent past as well as firms with a lower status than the firms where they currently serve. In addition, we find that interlocking directors' experience is less likely to lead to new-market entry for firms that lack new-product development experience and that exhibit a high level of market overlap with interlocked firms.
The Relationship between Transformational Leadership and Organizational Culture in National Oil Corporation of Libya

The purpose of the study is to investigate the relationship between transformational leadership and organizational culture in National Oil Corporation of Libya. This research was carried out by measuring the data gathered from the five point likert scale. The Multifactor Leadership Questionnaire (MLQ) was used to measure transformational leadership, while the Organizational Culture Assessment Instrument (OCAI) was used to measure organizational culture. Quantitative survey method was applied and a sample of 227 employees of National Oil Corporation of Libya was selected to answer the instrument. SPSS software was used to analyze the data collected based on descriptive statistics (mean, standard deviation, percentage, Correlation and Regression). The empirical results indicate that the leaders of National Oil Corporation of Libya follow transformational leadership style to manage their organization, while the relationship between transformational leadership and organizational culture was positive significant relationship and Hierarchy culture was a dominant culture in NOC of Libya.
MISALIGNMENT OF MAGNETIC FIELDS AND OUTFLOWS IN PROTOSTELLAR CORES

We present results of λ1. 3 mm dust-polarization observations toward 16 nearby, low-mass protostars, mapped with ∼2. ″5 resolution at CARMA. The results show that magnetic fields in protostellar cores on scales of ∼1000 AU are not tightly aligned with outflows from the protostars. Rather, the data are consistent with scenarios where outflows and magnetic fields are preferentially misaligned (perpendicular), or where they are randomly aligned. If one assumes that outflows emerge along the rotation axes of circumstellar disks, and that the outflows have not disrupted the fields in the surrounding material, then our results imply that the disks are not aligned with the fields in the cores from which they formed.
Management Forecasts in Japan: Do Managers Accurately Estimate Costs When They Issue Management Forecasts?

Virtually all firms listed on Japanese stock exchanges report point forecasts of sales and earnings in their annual press releases. The availability of management forecasts in Japan provides a unique research opportunity to investigate managers’ prediction of cost behavior of their company. Forecasted costs are available by subtracting forecasted earnings from forecasted sales. Using recent “sticky cost” research methods, the forecasted rate of change in costs can be compared with the actual rate of change in costs. Specifically, I describe the forecasted rate of change in costs as a function of the forecasted rate of change in sales, and comparing the forecasted rate of change in costs with the actual rate of change in costs. The rationale for this approach is, in theory, that costs are resources sacrificed to generate sales; hence, it is generally expected that costs increase (decrease) as sales increase (decrease). Basically, focusing on the relationship between forecasted sales and costs provide deeper insights into management earnings forecasts than focusing on the forecasted earnings because earnings are the aggregated measure of sales and costs. The major findings of this paper are that managers underestimate the rate of increase in costs when sales are expected to increase; however, they tend to overestimate the rate of decrease in costs when sales are expected to decrease, indicating that costs are underestimated regardless of the forecasted direction of change in sales. These findings imply that optimistic bias in management earnings forecasts can partly be attributed to the forecast error of rate of change in costs.
Teaching Next Generation Computing Skills; The Challenge of Embedded Computing

As new paradigms, such as pervasive computing and ambient intelligence change the nature of the computer application market place, so do the skills and educational technology needed by students and teachers. The once dominant PC now finds itself outnumbered by several orders of magnitude by much smaller and cheaper embedded computers which can extend the internet from being just a means of connecting personal computers together, to enabling a world of connected “things”; the so-called “internet of things”. In this world hundreds and even thousands of tiny service providing embedded-computers deliver a variety of services to us (some physical, some information) in ways that enable exciting new lifestyles and business opportunities. Applications range from the creation of digital homes (with their myriad of high-tech appliance), smart vehicles (cars aeroplanes & robotics) through to telecommunications (mobile phones, personal navigation or mobile learning). At the heart of this new technology is the “embedded-computer” which, from a software developers perspective, is significantly different to conventional desktop computers as they need to operate in real-time with computationally small resources and, in general, don't have inbuilt keyboards, displays or programming tools. All these factors conspire to bring significantly different educational and training requirements from older generations of computers, such as PCs. In this paper we examine these issues and introduce a set of modularised tools to arm universities, and other training institutions, with the means to support the acquisition of these key skills by students in a motivating and educationally sound way.
Hedge Fund Boards and the Market for Independent Directors

We provide the first examination of hedge fund boards and their directors. The majority of directorships are held by extremely busy independent directors. These directors are sought by funds because they have more reputational capital at stake, making them independent and credible monitors whose presence can certify fund quality to investors. Busy independent directors are more likely to be hired by high-quality funds, and their departure from the board is associated with investor withdrawals. Moreover, funds with busy independent directors are less likely to commit fraud, abuse discretionary liquidity restrictions, or engage in performance-based risk shifting.
Salvage Therapy with Atazanavir/Ritonavir Combined to Tenofovir in HIV-Infected Patients with Multiple Treatment Failures: Randomized Anrs 107 Trial

Background Ritonavir (RTV)-boosted atazanavir (ATV) and tenofovir disoproxil fumarate (TDF-DF) are promising in highly experienced patients because of their pharmacokinetic profile, activity, safety and resistance properties. Methods A 26-week study of the safety and efficacy of RTV-boosted ATV plus TDF-DF was conducted in 53 HIV-infected patients who were failing their current highly active antiretroviral therapy (HAART) regimen. Patients with history of failure to at least two protease inhibitors (PIs) and one non-nucleoside reverse transcriptase inhibitor (NNRTI) were randomized to either continue their current regimen (group 1) or replace the PI by ATV (300 mg once daily) boosted by RTV (100 mg; group 2) for 2 weeks. Then, all patients received the same combination of ATV, RTV and TDF-DF (300 mg) plus optimized NRTIs regimen. Results At baseline, median CD4+ T-cell count was 206/mm3, median viral load (VL) 5.0 log10/ml and median numbers of NRTI, NNRTI and PI resistance mutations were 7, 1 and 8, respectively. At week 2, median VL remained unchanged from baseline in group 2 as compared with group 1 (-0.1 vs -0.1 log10/ml). At week 26, a mild decrease in median VL from baseline of 0.2 log10/ml was observed, with 16 (31%) and 9 (17%) patients exhibiting a decrease in viral load of at least 0.5 and 1.0 log10/ml, respectively. Baseline phenotypic and genotypic resistance to ATV were the most predictive independent factors of virological response. The regimen was well tolerated. Conclusion In these very advanced patients failing highly HAART, the combination of boosted ATV plus TDF-DF yielded low antiretroviral activity.
Sensemaking and sensegiving in strategic change initiation

This paper reports an ethnographic study of the initiation of a strategic change effort in a large, public university. It develops a new framework for understanding the distinctive character of the beginning stages of strategic change by tracking the first year of the change through four phases (labeled as envisioning, signaling, re‐visioning, and energizing). This interpretive approach suggests that the CEO's primary role in instigating the strategic change process might best be understood in terms of the emergent concepts of ‘sensemaking’ and ‘sensegiving’. Relationships between these central concepts and other important theoretical domains are then drawn and implications for understanding strategic change initiation are discussed.
[Celecoxib induces cell cycle arrest and apoptosis in human tongue squamous carcinoma cell line Tca8113].

OBJECTIVE To investigate the effect of celecoxib on the cell cycle and apoptosis in human tongue squamous cell carcinoma (HTSCC) cell line Tca8113. METHODS Tca8113 cell line was cultured in the presence of different concentrations of celecoxib. MTT assay was used to measure cell survival rate, and flow cytometry performed to analyze the cell cycle distribution. Annexin V-FITC/PI staining was used to detect the early changes of apoptosis, and transmission electron microscope employed to observe the ultrastructural changes of the apoptotic cells. RESULTS Celecoxib inhibited the proliferation of Tca8113 cells in a dose-dependent manner, the effect of which was mediated by inducing cell cycle arrest mainly in G1/S phase. Flow cytometry and ultrastructural observation demonstrated an early to late stage changes of the apoptotic cells exposed to increased concentrations of celecoxib. CONCLUSION Celecoxib dose-dependently inhibits the proliferation of Tca8113 cells by causing cell cycle arrest and inducing apoptosis.
Morphology of the regiones ethmoidalis and orbitotemporalis in Galea musteloides Meyen 1832 and Kerodon rupestris (Wied-Neuwied 1820) (Rodentia: Caviidae) with comments on the phylogenetic systematics of the Caviidae

The present study describes the fetal regions ethmoidalis and orbitotemporalis of the cranium of Galea musteloides and Kerodon rupestris and compares them with Galea spixii and Cavia porcellus. The fetal crania of these representatives of the Caviinae were serially sectioned and 3D plate reconstructions were built. For a broader scope, serially sectioned heads of the caviomorph taxa Hydrochaeris hydrochaeris and Dasyprocta leporina were also examined. The ethmoidal and orbitotemporal regions of the cranium provides characters that are pertinent to the discussion of systematics of the Caviinae. Nine cranial characters were identified as being significant and discussed phylogenetically. Taking the monophyly of the Cavioidea as given, two characters are autapomorphic for the genus Galea: the reduction of the crista semicircularis and the lacrimale forming the ‘arco antorbitario’ (Kraglievich 1930). Cavia is the sister group of Galea; synapomorphic characters are the extent of the processus palatinus medialis of the praemaxillare and the presence lamina pterygoidea of the alisphenoid. There were no apomorphic characters of the structural complexes examined that could support the Caviinae. The reduced and nonperforated alisphenoid is an autapomorphic feature of the Caviidae. The division of the nasoturbinale is evidence for a sistergroup relationship of the Hydrochaeridae and the Caviidae. Autapomorphic characters for the Cavioidea include the ventrolateral opening of the organon vomeronasale and the lateral prolongation of the lacrimale.
Association of Varroa destructor females in multiply infested cells of the honeybee Apis mellifera

The genetic diversity of Varroa destructor (Anderson & Trueman) is limited outside its natural range due to population bottlenecks and its propensity to inbreed. In light of the arms race between V. destructor and its honeybee (Apis mellifera L.) host, any mechanism enhancing population admixture of the mite may be favored. One way that admixture can occur is when two genetically dissimilar mites coinvade a brood cell, with the progeny of the foundresses admixing. We determined the relatedness of 393 pairs of V. destructor foundresses, each pair collected from a single bee brood cell (n = five colonies). We used six microsatellites to identify the genotypes of mites coinvading a cell and calculated the frequency of pairs with different or the same genotypes. We found no deviation from random coinvasion, but the frequency of cells infested by mites with different genotypes was high. This rate of recombination, coupled with a high transmission rate of mites, homogenized the allelic pool of mites within the apiary.
Employee Attitudes Towards Safety Management in Manufacturing Sector in Malaysia

Purpose - This study examines how employees’ attitude of personal involvement, communication and physical work environment will influence the safety management. The purpose of this research is to investigate employee’s attitude and behaviour towards safety in manufacturing industries in Malaysia.Design/Methodology/Approach - Data were collected from a large manufacturing organisation using a questionnaire. A total of 96 valid questionnaires were returned and formed the basis subsequent analyses. Data Analysis - Multiple Linear Regression Model is employed in order to analyze the data.Findings - This study finds the positives relationships between employees’ attitude of personal involvement, communication and physical work environment and the safety management.Originality/value - This study contributes in exposing the strength of employees’ attitude against the safety management and how individual responsibility are the centre of the model.
Fertility and the Personal Exemption : Comment By Richard Crump and

One of the most commonly cited studies on the effect of child subsidies on fertility, Whittington, Alm, and Peters (1990), claimed a large positive effect of child tax benefits on fertility using time series methods. We revisit this question in light of recent increases in child tax benefits by replicating this earlier study and extending the analysis. We do not find strong evidence to justify the model specification from the original paper. Moreover, even if the original specification is appropriate, we show that the Leslie A. Whittington, James Alm and H. Elizabeth Peters results are not robust to more general measures of child tax benefits. (JEL: C22, H24, J13)
Diversity of Synanthropic Mites in Kolkata Metropolis, India

The synanthropic mites are those which regularly inhabit human settlements and human constructions where they form permanent or intermittent, independent or semi independent popUlation (Kucheruk, 1965 and Rosicky, 199]). The group chiefly consisting of mite fauna inhabiting house dust (floor dust and bed dust), stored product, house hold storages and granaries, bird's nest, cattle sheds and those occuring in roof gardens. The dust mites are of great concern to human health as they are directly responsible for causing nasobronchial allergic disorders 1 ike allergic rhinitis, eczema, bronchial asthma etc. Stored product mites are important as nlajority of those directly feed upon the grain contents or on food staffs making those unsuitable for human consumption or make those unmarketable. Some of the mites inhabiting cattle sheds cause nuisance and are of great veterinary importance. The nest associated mites may act as vectors of some viral diseases while roof garden mites cause damage to ornamental plants.
Preferential Stimulation of Extracellular Release of Dopamine in Rat Frontal Cortex to Striatum Following Competitive Inhibition of the N‐Methyl‐d‐Aspartate Receptor

Abstract: Using a brain microdialysis technique, we have shown in the rat that local infusion of a selective and competitive N‐methyl‐d‐aspartate (NMDA) receptor antagonist, cis‐4‐phosphonomethyl‐2‐piperidine carboxylic acid (CGS‐19755), into the medial frontal cortex via dialysis tubing caused a concentration‐related increase in the extracellular release of dopamine, 3,4‐dihydroxyphenylacetic acid, and homovanillic acid in the cortical region. Coinfusion of a sodium channel blocker, tetrodotoxin, completely inhibited the ability of the NMDA antagonist to augment frontal dopamine metabolism. These findings suggest that dopamine neurons projecting to the frontal cortex might be under a tonic transsynaptic inhibition exerted by excitatory amino acid neurotransmission via the NMDA receptor at the level of dopamine terminal fields.
Factors Affecting Continuous Intention to Use Mobile Wallet : Based on Value-based Adoption Model

초 록모바일 쿠폰과 멤버십 카드를 통합적으로 관리하는 모바일 지갑은 사용 편리성과 경제적 혜택으로 인해 빠르게 성장하고 있는 모바일 서비스 중의 하나이다. 그러나 빠른 성장에도 불구하고 모바일 지갑을 지속적으로 사용하지 않는 단기 사용자의 증가는 모바일 지갑 서비스 제공자들이 수익창출을 위해 해결해야 할 주요한 문제점이 되고 있다. 본 연구에서는 모바일 지갑 사용자의 서비스 사용기간을 늘리기 위한 주요 고려사항을 도출하기 위해, 모바일 지갑 사용자의 지속적인 사용의도에 영향을 주는 요인을 이익(Benefit)과 비용(Sacrifice)측면으로 나누어 종합적으로 분석 가능한 VAM(Value-based Adoption Model)을 적용하여 검증하였다. 연구결과, 이익 측면에서는 유용성, 가치표현, 인지된 보안과 즐거움이 지각된 가치에 유의한 영향을 미치는 것으로 나타났으며, 비용 측면에서는 기술의 복잡성이 지각된 가치에 유의한 영향을 미치는 것으로 확인되었다. 또한, 지각된 가치는 지속사용의도와 유의한 관계를 갖는 것으로 검증되었다. 본 연구결과를 활용해 모바일 지갑 서비스 제공자가 단기 사용자를 위한 서비스의 개선 및 마케팅 시에 기능 측면뿐만 아니라 감성적 측면의 요인들까지 고려할 수 있을 것으로 기대한다. ABSTRACTMobile wallet that can keep coupons and membership cards for mobile is one of rapidly growing services due to its usability and financial benefit. However, in spite of its rapid growth, the increase of users who do not use continuously it is an important consideration to service providers for making a profit. This study aims to test the effects of factors affecting the continuous use intention of mobile wallet based on VAM (Value-based Adoption Model) which can analyse them in both benefit and sacrifice aspects, so as to suggest considerations to increase the use period of mobile wallet for service providers. The research findings supported the hypotheses regarding to the effects of usefulness, value-expression, perceived