Miracle-dz/UniFAR-FTUs huggingface dataset:
Ancient DNA evidence reveals that the Y chromosome haplogroup Q1a1 admixed into the Han Chinese 3,000 years ago

Y chromosome haplogroup Q1a1 is found almost only in Han Chinese populations. However, it has not been found in ancient Han Chinese samples until now. Thus, the origin of haplogroup Q1a1 in Han Chinese is still obscure. This study attempts to provide answer to this question, and to uncover the origin and paternal genetic structure of the ancestors of the Han Chinese.
Oxygen transport dynamics of acellular hemoglobin solutions in an isovolemic hemodilution model in swine.

BACKGROUND One of the perceived advantages of a hemoglobin-based blood substitute is the provision of oxygen-carrying capacity. Although the hemodynamic response to the infusion of acellular hemoglobin solutions has been extensively studied, less is known about the oxygen transport dynamics of such solutions. We hypothesized that acellular hemoglobin solutions are useful oxygen carriers in anemic states and that higher P50 solutions transport O2 more efficiently than low P50 solutions. We sought to quantify O2 transport dynamics of hemoglobin solutions in an isovolemic hemodilution model in swine. METHODS Eighteen swine were anesthetized, ventilated, and instrumented for hemodynamic measurements and for withdrawal of arterial and mixed venous blood. The swine were randomized into three groups and progressively bled from an initial hematocrit (Hct) of 30% to Hcts of 19%, 13%, and 8% using isovolemic exchange with pyridoxalated hemoglobin polyoxyethylene conjugate (PHP, n = 6); an identical hemoglobin solution without the pyridoxalation, resulting in a low P50 solution (POE-Hb, n = 6); or an osmotically similar control solution of pentastarch (PS, n = 6). Hemodynamic measurements, arterial and mixed venous O2 content, and O2 extraction ratio (ER), were determined in whole blood (WB), the red blood cell (RBC) phase, and the plasma phase utilizing a compartmentalized approach. RESULTS Mean pulmonary arterial pressure was higher with hemodilution in the PHP and POE-Hb groups than in the PS group (p < 0.05). Cardiac index increased with hemodilution in all groups, but was significantly less than the cardiac index in the PS group at Hcts = 19% and 13%. Oxygen delivery and consumption were maintained at all hematocrits at baseline levels in the PHP and POE-Hb groups, but O2 delivery was significantly decreased in the PS group at Hct = 8% (p < 0.05 for PS vs. baseline and p < 0.05 for PHP and POE-Hb vs. PS). Oxygen extraction ratio increased with progressive hemodilution in both the RBC hemoglobin and plasma phases to a maximum of 39% for PHP and 36% for POE-Hb at Hct = 8%. The percent contribution from the plasma phase to total oxygen delivery and consumption likewise increased with hemodilution to maximum values of 52.7% (PHP) and 68.2% (POE-Hb) for delivery and 40.9% (PHP) and 39.3% (POE-Hb) for consumption. CONCLUSION Acellular hemoglobin solutions provide a significant contribution to O2 delivery and consumption, particularly in severe anemia, in this model of isovolemic exchange. The differences in the P50 of the two hemoglobin solutions do not appear to significantly influence oxygen dynamics over the range of hematocrits studied.
A qualitative evaluation of medical student learning with concept maps

Purpose and Aims: The purpose of this study was to investigate the ways in which the use of concept maps influenced the learning processes of third year internal medicine students in the context of medical education. Reported here are the qualitative results of this study. Methods: One–hundred thirty four medical students were taught to use concept mapping as a learning strategy at the beginning of their internal medicine rotations. Upon completion of the internal medicine rotation students were asked to evaluate how concept maps fostered the process of linking theoretical information to clinical practice. Additionally, students described how concept maps impacted their learning. Results: In this study, concept maps fostered a positive connection between theory and practice. Additionally, students described three major themes impacting their learning: concept mapping as a facilitator of knowledge integration and critical thinking, as a teaching methodology and finally, as a learning method. Conclusions: This study suggests concept maps may be an instructional method to foster the learning and thinking process of medical students.
Development of Quality Index Method for anchovy (Engraulis anchoita) stored in ice: Assessment of its shelf-life by chemical and sensory methods

The objective of this study was to develop a quality index method for Engraulis anchoita stored in ice and to determine its shelf-life based on this quality index method and chemical indices such as total volatile bases and thiobarbituric acid-reactive substances. Besides, the chemical composition with emphasis on the polyunsaturated fatty acids content was determined. The results indicate that E. anchoita is a valuable protein source and lipid with important content of n-3 polyunsaturated fatty acids. The developed quality index method scheme was composed of 28 demerit points, divided into 4 parameters and 10 attributes. All attributes showed correlation with time of storage (R > 0.90). The quality index (QI) presented a linear relationship with storage (QI = 2.55x days in ice + 1.76; R2 = 0.98). In the shelf-life assessment-based quality index method, the rejection sensory point was observed after 7 days of storage due to the presence of unpleasant odours and deteriorated appearance. The total volatile basic nitrogen value remained below the upper limit of acceptability during the 10 days of ice storage. The evolution of thiobarbituric acid-reactive substances indicates lipids oxidation during the storage of anchovies. According to the results, the quality index method scheme developed for the E. anchoita stored in ice could be considered adequate to evaluate their freshness and to estimate its shelf-life.
Local Authority Homelessness Prevention in England: Empowering Consumers or Denying Rights?

High profile commitments to stemming homelessness have been integral to New Labour's emphasis on promoting social inclusion since 1997. During this period official policy has favoured an increasingly assertive approach in this area as exemplified by the successful post-1998 programmes to reduce street homelessness. The period since 2002 has seen a broader ministerial drive to reduce homelessness, mainly through encouraging local authorities (LAs) to adopt more pro-active, preventative approaches to the problem. Aided by substantial central funding LAs have responded by developing numerous initiatives to this end. Particularly where they involve assisting people at risk of homelessness to access private tenancies, such schemes are often justified by LAs as empowering consumers and promoting choice. With official homelessness figures in England having fallen dramatically since 2003/04, it would appear that the new ‘homelessness prevention regime’ has made a marked impact. However, what such figures do not reveal is the extent to which this results from the adoption of more restrictive interpretations of LA duties under the homelessness legislation. This could mean that the problem is being re-defined rather than resolved. Drawing on a recently completed study, this paper explores the tensions between helping resolve people's housing problems, on the one hand, and upholding legal rights to accommodation, on the other.
AN INJECTION OF BASE MONEY AT ZERO INTEREST RATES: EMPIRICAL EVIDENCE FROM THE JAPANESE EXPERIENCE 2001-2006

Many macroeconomists and policymakers have debated the effectiveness of the quantitative monetary-easing policy (QMEP) that was introduced in Japan in 2001. This paper measures the effect of the QMEP on aggregate output and prices, and examines its transmission mechanism, based on the vector autoregressive (VAR) methodology. To ascertain the transmission mechanism, we include several financial market variables in the VAR system. The results show that the QMEP increased aggregate output through the stock price channel. This evidence suggests that further injection of base money is effective even when short-term nominal interest rates are at zero.
Bargaining and the Interdependent Stages of Civil War Resolution

This article examines civil war resolution as a process comprised of multiple interdependent stages. It engages directly the idea that peace emerges only as a process comprised of battle, negotiation, agreement, and implementation of an agreement. I hypothesize that events at earlier stages of the peace process have implications for later stages, but not always in the same ways. Drawing on bargaining models of war, I consider how two factors that might prevent successful bargaining—stalemates and the number of actors—can encourage cooperation early in a peace process but impede lasting cooperation at later stages. Using a nested dichotomies statistical approach to capture interdependence, I find support for the argument that stalemates and the number of actors have different effects depending on the stage of the peace process. The results substantiate the need in theoretical and policy work to consider peace as an interdependent, sequential process.
Citizen Major? The Rationale and Impact of The Citizen's Charter

John Major's introduction of the Citizen's Charter in July 1991 was intended to mark a watershed in the provision of public services in the United Kingdom. Its subsequent evolution has attracted international attention and, according to the Government, the Charter, although less than half-way through its ten-year timescale, has resulted in significant improvements in public service delivery and has been instrumental in effecting a cultural change in the attitudes of public service personnel. These improvements have occurred within the context of a much wider series of measures pursued by Conservative Governments since 1979, all of which have resulted in a radically transformed public sector. The real significance of the Charter, however, is not easily reconciled with Governmental rhetoric. This paper defines the Charter programme and evaluates its rationale and impact.
A Self-Sustainable Power Management System for Reliable Power Scaling Up of Sediment Microbial Fuel Cells

Sediment microbial fuel cells (SMFCs) are considered a promising renewable power source for remote monitoring applications. However, existing SMFCs can only produce several milliwatts of power, and the output power is not scaled linearly with the size of SMFCs. An effective alternative method to increase the output power is to independently operate multiple SMFCs, each of which has an optimal size for maximum power density. Independently operated SMFCs have electrically isolated electrodes (anodes/cathodes), which complicates the design of a suitable power management system (PMS). This paper describes the challenges in designing a PMS that can harvest energy from multiple independently operated (mio) SMFCs and accordingly proposes a design solution. From experimental results, the proposed PMS demonstrates reliable output power scaling up of mio-SMFC. The proposed PMS is self-sustainable because it is powered entirely from harvested energy without requiring additional external power sources.
Time horizon trading and the idiosyncratic risk puzzle

We analyse whether the idiosyncratic risk puzzle reported by Ang et al. can be explained by the existence of market participants with different investment horizons. We adopt a wavelet multiresolution analysis to decompose the returns distribution for different time scales. Our approach divides the nonlinear link between expected returns and idiosyncratic risk into two linear relationships, a positive one for long-run investors and a negative one for short-run investors, indicating that the puzzle disappears as the wavelet scale increases (long-term horizons). Our results are robust to several types of wavelets, to different definitions of short-term investors and to various measures of idiosyncratic risk.
Electron microscopy of bacteriophage phi 6 nucleocapsid: two-dimensional image analysis

Electron micrographs of negatively stained nucleocapsids isolated from intact, wild-type phi 6 bacteriophage revealed three distinct morphological forms. Two-dimensional analysis of electron micrographs of two of these forms and image averaging of all forms are consistent with a dodecahedral structure embodied in the phi 6 nucleocapsid.
Returning to Work After Maternity Leave: Childcare and Workplace Flexibility

This article explores how responsibilities for childcare are managed as part of family decisions made around the return to work following a period of maternity leave. We surveyed all women health professionals identified as on maternity leave on payroll records of the Health Department, Western Australia, and one private sector national provider of hospital services. Survey questions were designed following a review of the literature and prior empirical work. The design enabled us to collect both quantitative information and interpretive qualitative responses from participants. Over 50% of respondents expected to have childcare provided wholly by family members, while 15% anticipated the use of formal arrangements alone. The planned arrangements for care can best be understood within a framework of a ‘family budget’ of time to be allocated between market-based work and childcare. Attitudes to childcare are central to this ‘time economies’ framework. Respondents experienced dissonance between the stated organizational family-friendly policy of their workplaces and practices at the management level. Employer-centred flexibility often disrupted their child-care arrangements. We identify important employment policy issues for workplaces that would facilitate the optimal return to the workforce by professional women following maternity leave.
Grappling With the Centipede: Defence of Backward Induction for BI-Terminating Games

According to the standard objection to backward induction in games, its application depends on highly questionable assumptions about the players' expectations as regards future counterfactual game developments. It seems that, in order to make predictions needed for backward reasoning, the players must expect (i) each player to act rationally at each node that in principle could be reached in the game, and also to expect (ii) that this confidence in the future rationality of the players would be kept by each player come what may: even at the game-nodes that could only be reached by irrational play. Both expectations seem to be rather unreasonable: a player's initial disposition to rational behaviour may be weakened by a long stretch of irrational play on his part and, even more importantly, his initial confidence in the other players' future rationality may be undermined by an irrational play on their part. For different formulations of this objection see Binmore (1987), Reny (1988) and (1989), Bicchieri (1989), Pettit and Sugden (1989). (For defences of backward induction see Sobel (1993) and Aumann (1995) and (1996). )
Tourism as a Tool of Sustainable Regional Development and the Importance of Clusters in Latvia: The Example of Sigulda and Ventspils

This paper evaluates the role of tourism in sustainable regional development in Latvia. The authors have focused on the identification and mapping of spatial structures in Latvia, choosing the most popular tourist destinations Sigulda and Ventspils cities as textbook examples of such territories. The concept of clusters has been chosen as the most appropriate theory for tourism as a tool of urban development and evaluating the spatial structure of tourism. The result of the research was the identification of a tourism cluster and mapped city influence zone in Sigulda and Ventspils, where spatial processes have developed differently. This research has not only confirmed the advantage of a cluster – the ability to attract new business innovations despite the existing competition in the area – but it has also showed the different character of urban development and integration with surrounding counties in accordance with sustainability principles.
Organizational Legitimacy and Stakeholder Information Provision1

One interpretation of the concept of organizational legitimacy is that it stems from the cultural values of society, and suggests that businesses operate under a mandate that may be withdrawn if organizations are seen not to be doing the 'right' things. This suggests there is something in the nature of a principal-agent relationship in existence, and that some form of accountability is then owed by the agent (the organization) to the principal (society). This paper seeks to investigate the nature of this accountability, distinguishing between the accountability which exists towards those elements of society with which an organization has a contractual relationship, and those where it does not. Adopting a pluralist stance, stakeholder theory is then used to illustrate the possible nature of both the form of legitimacy relationship extant, and of the accountability that the principal might expect of the agent.
Seasonal Variation of Sexual Abuse in Santiago de Chile

Background: Seasonal variations of sexual crime have been seldom studied in the world. Santiago, a city situated at 33° south latitude with a well defined four season climate, has a reliable forensic registry, providing a good opportunity for the assessment of seasonality in this type of crime. Materials and Methods: After studying monthly records of sexual abuse from the registry of the Servicio Médico Legal of Santiago between 1990 and 2001, a ratio of observed to expected monthly frequency was obtained, allowing the assessment of the seasonal character of the phenomenon. Results: A total number of 11,844 cases of sexual abuse were recorded during 12 years of the study. Statistically significant differences could be demonstrated between spring and autumn, with a peak in November and a nadir in June. Conclusions: A distinct seasonal pattern can be set forth for sexual abuse in Santiago, Chile.
On the Link between Urban Location and the Involvement of Knowledge-Intensive Business Services Firms in Collaboration Networks

Herstad S. J. and Ebersberger B. On the link between urban location and the involvement of knowledge-intensive business services firms in collaboration networks, Regional Studies. Knowledge-intensive business services firms can play a key role in modern economies by linking localized collaboration networks to global knowledge flows, and by actively serving in support of knowledge diffusion across institutional and sectoral divides. The extent to which they do is dependent on the resources available locally. This paper uses the unique establishment-level innovation data available in Norway to investigate whether location in urban labour market regions influences the geographical scope of collaborative linkages maintained within and outside the realm of clients. It proceeds to consider whether the diversity of partner types used locally, domestically and abroad differ between locations.
Osteoclasts can be induced in fish having an acellular bony skeleton.

Kelp bass (Paralabrax clathratus) and leopard sharks (Triakis semifasciata) are characterized by an acellular (anosteocytic) bony skeleton and a focally calcified cartilaginous endoskeleton, respectively. These skeletal forms are not considered to function as mineral reservoirs. Previous studies showed that implanted bone particles are resorbed in rats by large multinucleated cells with ultrastructural features (ruffled borders) characteristic of osteoclasts. We tested the ability of fish to resorb bone matrix and to adapt to reduced salinity conditions. Bone particles were implanted in sharks and bass maintained in seawater (34 ppt, 40.5 mg of calcium per dl) or in diluted seawater (26 ppt, 28.5 mg of calcium per dl). Sera and elicited tissues were harvested 4 weeks later. In sharks, bone particles were not resorbed, and multinucleated cells were not evident under either normal or hyposalinity conditions. Shark sera were isoosmolar with the seawater or diluted seawater, with serum chemistries of the hyposalinity group reflecting the 23% reduction in environmental minerals and electrolytes, compared to sharks in normal seawater. In marked contrast, bass adapted to diluted seawater resorbed bone particles and maintained normal serum chemistries. Electron microcopy showed that the bone particles were surrounded by large, foamy multinucleated cells, many with membrane specializations typical of osteoclasts from higher vertebrates, i.e., extensive clear zones apposed to intact bone matrix and active ruffled borders overlying areas of matrix undergoing dissolution. Although osteoclasts had not been described in these fish, this study shows that bass have stem cells that can be stimulated to differentiate into bone-resorbing osteoclasts.
Small is beautiful : The efficiency of credit markets in the late medieval Holland

In this paper, we analyse the functioning of private capital markets in Holland in the late medieval period. We argue that in the absence of banks and state agencies involved in the supply of credit, entrepreneurs' access to credit was determined by two interrelated factors. The first was the quality of property rights protection and the extent to which properties could be used as collateral. The second was the level of interest in borrowing money at the time as well as such borrowing compared with the interest rates on risk-free investments. For our case study, the small town of Edam and its hinterland, De Zeevang, in the fifteenth and sixteenth centuries, we demonstrate that properties were used as collateral on a large scale and that interest rates on both small and large loans were relatively low (about 6 percent). As a result, many households (whether headed by men or women) owned financial assets and/or debts, and the degree of financial sophistication was relatively high. Copyright , Oxford University Press.
Acute glucose and lactate metabolism are associated with cognitive recovery following traumatic brain injury

Traumatic brain injury (TBI) is associated with acute cerebral metabolic crisis (ACMC). ACMC‐related atrophy appears to be prominent in frontal and temporal lobes following moderate‐to‐severe TBI. This atrophy is correlated with poorer cognitive outcomes in TBI. The current study investigated ability of acute glucose and lactate metabolism to predict long‐term recovery of frontal‐temporal cognitive function in participants with moderate‐to‐severe TBI. Cerebral metabolic rate of glucose and lactate were measured by the Kety‐Schmidt method on days 0–7 post‐injury. Indices of frontal‐temporal cognitive processing were calculated for six months post‐injury; 12 months post‐injury; and recovery (the difference between the six‐ and 12‐month scores). Glucose and lactate metabolism were included in separate regression models, as they were highly intercorrelated. Also, glucose and lactate values were centered and averaged and included in a final regression model. Models for the prediction frontal‐temporal cognition at six and 12 months post‐injury were not significant. However, average glucose and lactate metabolism predicted recovery of frontal‐temporal cognition, accounting for 23% and 22% of the variance, respectively. Also, maximum glucose metabolism, but not maximum lactate metabolism, was an inverse predictor in the recovery of frontal‐temporal cognition, accounting for 23% of the variance. Finally, the average of glucose and lactate metabolism predicted frontal‐temporal cognitive recovery, accounting for 22% of the variance. These data indicate that acute glucose and lactate metabolism both support cognitive recovery from TBI. Also, our data suggest that control of endogenous fuels and/or supplementation with exogenous fuels may have therapeutic potential for cognitive recovery from TBI.