Miracle-dz/UniFAR-FTUs huggingface dataset:
Delayed Onset of Oculogyric Crisis and Torticollis with Intramuscular Haloperidol

Objective To report a case of delayed-onset dystonic reactions, oculogyric crisis (OGC), and torticollis after treatment with intramuscular haloperidol lactate injection. Case Summary A 22-year-old Mexican American woman received intramuscular haloperidol lactate 7.5 mg followed 4 hours later by 10 mg. Twenty-six hours after the first injection, the patient reported that she was unable to lower her gaze and that her neck was stiff. She was immediately given intramuscular benztropine 2 mg; there was a nearly complete remission of symptoms within 15 minutes of treatment. An objective causality assessment revealed a probable relationship between the OGC/torticollis and haloperidol therapy. Discussion Dystonic reactions have been reported in 10–60% of patients treated with neuroleptic medication, most commonly when patients just start or increase the dose of the drug. The highest frequency of dystonic reactions has occurred in patients receiving high-potency neuroleptics. It has also been suggested that haloperidol-induced dystonic reactions are a result of the toxic metabolites of that agent. Conclusions OGC and torticollis reactions may occur 12–24 hours after treatment with a high-potency neuroleptic, even in the absence of symptoms of extrapyramidal side effects (EPSEs). The delayed dystonic reaction may begin suddenly (no early EPSE symptomatology).
Simple Computation-Universal Cellular Spaces and Self-Reproduction

Cellular spaces computationally equivalent to any given Turing machine are exhibited which are simple in the sense that each cell has only a small number of states and a small neighborhood. Neighborhood reduction theorems are derived in this interest, and several simple computationuniversal cellular spaces are presented. Conditions for computation-universality of a cellular space are investigated, and, in particular, the conjecture that unbounded but boundable propagation in a space is a sufficient condition is refuted. Finally, the computation-universal spaces derived in the study are used to introduce, via recursive function theory, examples of simple self-reproducing universal Turing machine configurations in one and two dimensions.
High expression of INHBA is an adverse prognostic factor for de novo acute myeloid leukemia

Abstract Inhibin-β A (INHBA) is a ligand of the transforming growth factor β superfamily and associated with tumorigenesis and tumor progression in solid tumors. In this study, we investigated the expression levels and clinical significance of INHBA in acute myeloid leukemia (AML). The results showed that high expression of INHBA was significantly correlated with elderly age (>60 years) (p = .038), adverse cytogenetic risks (p = .034), negative NPM1 mutation (p = .016), positive FLT3 internal tandem duplications (p = .011), and low hemoglobin levels (<60 g/dL) (p = .04). Patients with high levels of INHBA had poor responses to therapies as indicated by lower complete remission rate (p = .004), higher early death rate (p = .018), and shorter relapse-free survival (p = .04) and overall survival (p = .003). Moreover, multivariate analysis showed that high expression of INHBA was an independent adverse prognostic factor for AML. Taken together, our study suggested that high expression of INHBA was an adverse prognostic factor for de novo AML.
Shear Bond Strength of Different Adhesive Materials used for Bonding Orthodontic Brackets : A Comparative in vitro Study

Introduction: Bond strength is an important property and determines the amount of force delivered and treatment duration in orthodontics. Many light-cured bonding materials are being used; but it is required to determine the most efficient one with desired bond strength. Objective: To determine and compare the shear bond strength of three visible light-cured composites (Transbond XT, Heliositand Enlight) and two self-cured composites (Rely-a-bond and Concise). Materials & Method: 100 extracted premolars were collected and randomly divided into 5 test groups of different adhesives. Brackets were bonded to the teeth in each test group with the respective adhesive according to the manufacturer’s instructions. Each specimen was debonded using Universal Testing Machine and the shear bond strength for each specimen was calculated. All the groups were compared by ANOVA one-way test. Results: There were statistically significant differences among the five groups (P<0.05). The shear bond strength of Enlight (13.92 ± 3.92) is similar to Transbond XT (14.30 ± 4.35). Conclusion: Light cure composites showed higher bond strength than self cure composites.
Bulk Nanocrystalline  ${\hbox{SmCo}}_{6.6}{\hbox{Nb}}_{0.4}$ Sintered Magnet With ${\hbox{TbCu}}_{7}$-Type Structure Prepared by Spark Plasma Sintering

We prepared bulk nanocrystalline SmCo6.6Nb0. 4 sintered magnet material by spark plasma sintering technique. X-ray diffraction patterns show that the magnet exhibits a stable TbCu7 structure. Transmission electron microscopy indicates that the microstructure of the magnet is composed of SmCo6.6Nb0. 4 single-phase grains with an average grain size of 30 nm. Magnetic measurement shows that under a 7 T magnetic field, the coercivity of the magnet reaches as high as 2.8 T; the saturation magnetization and the remanence are 69.6 and 51.4 emu/g, respectively. The magnet exhibits good thermal stability with the coercivity of 0.48 T at 773 K, and the coercivity temperature coefficient beta of -0.169%/K.
Helicobacter pylori Primary Resistance to Metronidazole and Clarithromycin in Brazil

ABSTRACT Helicobacter pylori resistance to metronidazole was detected in 107 (52.97%) of 202 strains. Twenty (9.85%) strains, 18 of them harboring 23S ribosomal DNA mutations, were resistant to clarithromycin. Metronidazole resistance was associated with female gender. Resistance to metronidazole and resistance to clarithromycin were associated. Increasing clarithromycin resistance rates were observed over time.
Os indicadores financeiros tradicionais explicam a geração de valor no Brasil? Um estudo empírico com empresas não financeiras de capital aberto

No contexto atual dos mercados globalizados, as empresas enfrentam uma competicao cada vez mais complexa na obtencao de capital. Para atrai-lo, elas precisam oferecer retornos que remunerem o risco assumido pelos investidores, ou seja, gerar valor. Assim, o objetivo deste estudo foi verificar se os indicadores financeiros tradicionais, normalmente usados na analise financeira, estao relacionados a geracao de valor nas companhias abertas nao financeiras brasileiras. As tecnicas estatisticas utilizadas foram: correlacao, regressao multipla, regressao em painel e regressao logistica. Um dos principais resultados encontrados foi que pelo menos dois tercos dos indicadores financeiros utilizados para analise de empresas nao explicam a geracao de valor. Com base no universo pesquisado, os indicadores significativamente relacionados a geracao de valor, que podem ser considerados direcionadores gerais de valor do mercado brasileiro, foram: retorno sobre patrimonio liquido (ROE), retorno sobre ativo (ROA), spread do acionista, margem bruta, margem liquida e giro do ativo, todos com relacao direta com valor economico agregado (VEA). Alem disso, na analise dos setores economicos, por suas caracteristicas especificas, encontraram-se divergencias entre os indicadores financeiros considerados direcionadores de valor em cada um deles.
Information technology and economic development in Korea: a causality study

This paper examines the causality issue between information technology (IT) investment and economic development for Korea by applying modern time series techniques. Tests for unit roots, co-integration, and Granger causality are presented. The results show that bi-directional causality runs from IT investment to economic development for Korea. This means that increased IT investment directly affects economic development and that an increase in real income also influences IT investment. The study also discusses the implications of the results for addressing IT policy in Korea.
Trachoma among adults in Damot Gale District, South Ethiopia

PURPOSE To determine the prevalence of trachoma and its risk factors among adults in the Damot Gale District of south Ethiopia. METHODS A cross-sectional, community based survey was conducted in the Damot Gale District of south Ethiopia. A multi-stage sampling method was used to select subjects. RESULTS Out of 924 eligible subjects, 855 were examined, for a response rate of 92.5%. Active trachoma [follicles (TF), intense inflammation (TI) or TF/TI] was found in 20.6% (95% CI: 17.8–23.4%) of the subjects. The prevalence of trachomatous trichiasis (TT) and corneal opacity (CO) was 6.8% (95% CI: 5.1–8.5%) and 2.1% (95% CI: 1.0–3.1%), respectively. Females were affected by active trachoma twice as often as males [OR 2.13 (95% CI: 1.67–3.50, P < 0.0001)]. The prevalence of blinding trachoma (TT and CO) was also significantly higher among females [OR 3.03 (95% CI: 1.58–5.89, P < 0.001)]. Literacy and face washing were found to be significantly associated with less prevalence of active trachoma. CONCLUSION The prevalence of both active and cicatricial trachoma among adults residing in the Damot Gale District of south Ethiopia is very high. Although children are the main reservoirs of active trachoma, intervention strategies should address the fact that a high prevalence of active trachoma is also found among adults residing in hyperendemic areas.
Prevalencia de asma aguda en niños y adolescentes de Mérida, Yucatán, México

Objetivo: Conocer la prevalencia de asma aguda en el servicio de urgencias de un hospital de segundo nivel y determinar las variaciones estacionales del padecimiento. Material y metodos: Estudio retrospectivo, descriptivo y transversal efectuado en el servicio de Urgencias Pediatricas del Hospital General Agustin O’Horan de Merida, Yucatan, Mexico, del 1 de enero al 31 de diciembre de 2005. Se seleccionaron pacientes menores de 14 anos de edad. Resultados: Se registraron 7,674 consultas, de las cuales el asma aguda ocupo el tercer lugar (10.3%). De los 622 pacientes con asma aguda, 376 correspondieron al sexo masculino (60%); predominaron los ninos de un ano de edad (22.6%). Los meses con mayor demanda de atencion por crisis asmatica fueron diciembre (18.4%), octubre (14.1%) y septiembre (12.5%). Se encontro asociacion significativa entre el numero mensual de visitas a urgencias entre asma aguda e infeccion respiratoria superior (r= 0.9059, p= <0.001, IC 99%). Conclusiones: El asma aguda es una de las causas mas frecuentes de consulta en el servicio de urgencias pediatricas y existe correlacion entre la enfermedad e infecciones respiratorias
Fuzzy rule extraction from ID3-type decision trees for real data

This paper proposes a method to construct a fuzzy rule-based classifier system from an ID3-type decision tree (DT) for real data. The three major steps are rule extraction, gradient descent tuning of the rule-base, and performance-based pruning of the rule-base. Pruning removes all rules which cannot meet a certain level of performance. To test our scheme, we have used the DT generated by RIB3, an ID3-type classifier for real data. In this process, we made some improvements of RID3 to get a tree with less redundancy and hence a smaller rule-base. The rule-base is tested on several data sets and is found to demonstrate an excellent performance. Results obtained by the proposed scheme are consistently better than C4.5 across several data sets.
The Gilded Age “Bone Wars” and the Birth of Paleoindian Archaeology: Williston, Martin, Overton, and the 12 Mile Creek Site

The 12 Mile Creek Paleoindian site, excavated in 1895-6, was the first scientifically excavated Paleoindian site. Reported by Williston in 1902, at a time prior to the establishment of standards of evidence, he was left with little recourse but to affirm the experience and skills of the site's excavators, H. T. Martin and Thomas R. Overton. In fact, all three men were products of the Gilded Age “Bone Wars,” the highly public feud waged between O. C. Marsh and E. D. Cope. By the time the 12 Mile Creek site was dug, they had amassed considerable experience in fossil collection and preparation. Despite this and Williston's assurance, the site was not generally accepted by the anthropological elite of the day. This article fills in biographical information on these men and also adds new information, from period newspaper accounts that provide additional insights into the history of the site. These were published in the wake of the Lansing “Man” finds in 1902-3 and on the opening in 1906 of an exhibit featuring a reconstruction of a bison from the 12 Mile Creek site.
FDA summary of adverse events on electronic cigarettes.

The Center for Tobacco Products (CTP), Food and Drug Administration (FDA), oversees the implementation of the Family Smoking Prevention and Tobacco Control Act (TCA). As part of its responsibility in implementing the TCA, CTP receives and reviews voluntary communications from consumers, health care professionals, and concerned members of the public regarding a variety of tobacco products. Surveillance of adverse event (AE) reports allows regulatory agencies (1) to identify previously undetected safety concerns and take appropriate action to prevent further adverse events and (2) or to educate consumers about health and safety risks. Since the late 1980s, over 100 AE reports on tobacco products have been submitted to FDA (electronic cigarettes, n = 47; cigarettes, n = 36; smokeless tobacco, n = 14; other tobacco, n = 5). Notably, approximately half of all tobacco-related AE reports concern electronic cigarettes, the first of which was submitted in 2008.
Kallmann syndrome: 14 novel mutations in KAL1 and FGFR1 (KAL2)

Kallmann syndrome (KAL) combines hypogonadotropic hypogonadism and anosmia. Hypogonadism is due to Gonadotropin Releasing Hormone (GnRH) deficiency and anosmia is related to hypoplasia of the olfactory bulbs. Occasional symptoms include renal agenesis, bimanual synkinesia, cleft lip palate, dental agenesis. KAL is genetically heterogeneous and two genes have so far been identified, namely KAL1 (Xp22.3) and FGFR1/KAL2 (8p12), which underlie the X chromosome‐linked form and an autosomal dominant form of the disease, respectively. We studied a cohort of 98 unrelated Caucasian KAL patients. We identified KAL1 mutations in 14 patients, of which 7 (c.3G>A (p.M1? ), g.IVS1+1G>T, c. 570_571insA (p.R191fsX14), c.784G>C (p.R262P), c.958G>T (p.E320X), c. 1651_1654delinsAGCT (p.P551_E552delinsSX), c.1711T>A (p.W571R)) have not been previously reported. In addition, we found FGFR1 mutations in 7 patients, namely c.303G>A (p.V102I), C.385A>C (p.D129A), c.810G>A (p.V273M), c. 1093_1094delAG (p.R365fsX41), c.1561G>A (p.A520T), c. 1836_1837insT (p.Y613fsX42), c.2190C>G (p.Y730X), all of which were novel mutations. In this study, unilateral renal agenesis and bimanual synkinesia were exclusively found associated with KAL1mutations, cleft palate and dental agenesia with FGFR1mutations. © 2004 Wiley‐Liss, Inc.
Chemical composition changes of post-harvest coconut inflorescence sap during natural fermentation

Coconut inflorescence sap (CIS) is sweet, oyster-white and translucent and was reported to be highly nutritive and a good digestive agent. The chemical composition changes including total sugar, reducing sugar, ethanol, total acidity, volatile acid, amino acid, vitamin C and total phenolic contents of postharvest coconut inflorescence sap (PCIS) were investigated during a 12-day natural fermentation, and the variety and content of phenolic compounds of fresh coconut inflorescence sap (FCIS) and natural fermented coconut inflorescence sap (NCIS) were also studied by an high performance liquid chromatography (HPLC) system. Total acid, volatile acid and total phenolic contents increased during natural fermentation, while total sugar contents decreased during natural fermentation. The amino acid content declined steadily after harvesting until 3 days, but then remained almost constant. Vitamin C content decreased on day 1, slowly rose to 20.7 mg/L on day 3, and then decreased obviously. Five kinds of phenolic compounds were detected by HPLC. These compounds all increased in NCIS compared with FCIS; both NCIS and FCIS also contained other kinds of phenolic compounds.
On symbolic control design of discrete-time nonlinear systems with state quantized measurements

Most of the existing results available in the literature concerning symbolic control design of purely continuous or hybrid systems assume full information of the state which in concrete applications may be not available. This partial information to the controller requires to revisit existing methods on symbolic control design. This paper aims at addressing this issue and deals with symbolic control design with state quantized measurements of discrete-time nonlinear control systems affected by disturbances, with specifications expressed as regular languages.
A multicriteria framework with voxel-dependent parameters for radiotherapy treatment plan optimization.

PURPOSE To establish a new mathematical framework for radiotherapy treatment optimization with voxel-dependent optimization parameters. METHODS In the treatment plan optimization problem for radiotherapy, a clinically acceptable plan is usually generated by an optimization process with weighting factors or reference doses adjusted for a set of the objective functions associated to the organs. Recent discoveries indicate that adjusting parameters associated with each voxel may lead to better plan quality. However, it is still unclear regarding the mathematical reasons behind it. Furthermore, questions about the objective function selection and parameter adjustment to assure Pareto optimality as well as the relationship between the optimal solutions obtained from the organ-based and voxel-based models remain unanswered. To answer these questions, the authors establish in this work a new mathematical framework equipped with two theorems. RESULTS The new framework clarifies the different consequences of adjusting organ-dependent and voxel-dependent parameters for the treatment plan optimization of radiation therapy, as well as the impact of using different objective functions on plan qualities and Pareto surfaces. The main discoveries are threefold: (1) While in the organ-based model the selection of the objective function has an impact on the quality of the optimized plans, this is no longer an issue for the voxel-based model since the Pareto surface is independent of the objective function selection and the entire Pareto surface could be generated as long as the objective function satisfies certain mathematical conditions; (2) All Pareto solutions generated by the organ-based model with different objective functions are parts of a unique Pareto surface generated by the voxel-based model with any appropriate objective function; (3) A much larger Pareto surface is explored by adjusting voxel-dependent parameters than by adjusting organ-dependent parameters, possibly allowing for the generation of plans with better trade-offs among different clinical objectives. CONCLUSIONS The authors have developed a mathematical framework for radiotherapy treatment optimization using voxel-based parameters. The authors can improve the plan quality by adjusting voxel-based weighting factors and exploring the unique and large Pareto surface which include all the Pareto surfaces that can be generated by organ-based model using different objective functions.
Varying Importance of Soluble and Membrane CD14 in Endothelial Detection of Lipopolysaccharide1

The endothelial response to LPS is critical in the recruitment of leukocytes, thereby allowing the host to survive Gram-negative infection. Herein, we investigated the roles of soluble CD14 (sCD14) and membrane CD14 (mCD14) in the endothelial response to low level LPS (0.1 ng/ml), intermediate level LPS (10 ng/ml), and high level LPS (1000 ng/ml). Removal of sCD14 from serum and sCD14-negative serum prevented low level LPS detection and subsequent response. Addition of recombinant sCD14 back into the endothelial system rescued the endothelial response. GPI-linked mCD14 removal from endothelium or endothelial treatment with a CD14 mAb prevented responses to low-level LPS even in the presence of sCD14. This demonstrates essential nonoverlapping roles for both mCD14 and sCD14 in the detection of low-level LPS. At intermediate levels of LPS, sCD14 was not required, but blocking mCD14 still prevented endothelial LPS detection and E-selectin expression, even in the presence of sCD14, suggesting that sCD14 cannot substitute for mCD14. At very high levels of LPS, the absence of mCD14 and sCD14 did not abrogate TLR4-dependent, E-selectin synthesis in response to LPS. The MyD88 independent pathway was detected in endothelium (presence of TRIF-related adaptor molecule TRAM). The MyD88-independent response (IFN-β) in endothelium required mCD14 even at the highest LPS dose tested. Our results demonstrate an essential role for endothelial mCD14 that cannot be replaced by sCD14. Furthermore, we have provided evidence for a TRAM pathway in endothelium that is dependent on mCD14 even when other responses are no longer mCD14 dependent.
Positive unlabelled learning with applications in computational biology

Con el aumento de la cantidad de informacion almacenada, el uso de tecnicas de mineria de datos se han convertido en una pieza clave en muchos campos. Los algoritmos de induccion de clasificadores son herramientas muy utiles ya que permiten condensar la informacion contenida en las bases de datos en clasificadores que pueden luego ser usados para realizar predicciones sobre nuevos datos. Una de las aplicaciones de los algoritmos de induccion de clasificadores es la recuperacion de informacion, que puede ser definida como la recuperacion de los objetos de un tipo determinado (aquellos en los cuales estamos interesados, normalmente llamados 'positivos') de grandes conjuntos de objetos no etiquetados (es decir, objetos que no sabemos a que clase pertenecen). Las aproximaciones clasicas implican tener ejemplos positivos (ejemplos del tipo de objetos que queremos recuperar) y ejemplos negativos (ejemplos de objetos diferentes a los que queremos recuperar), pero no siempre hay disponibles ejemplos negativos. Por este motivo, durante los ultimos anos se han venido desarrollando algoritmos que permitan aprender clasificadores binarios en ausencia de ejemplos negativos. El tema de esta tesis es el aprendizaje a partir de ejemplos positivos y no etiquetados. Las contribuciones de esta tesis abarcan la induccion de modelos de clasificacion, el promediado de clasificadores, la seleccion de variables y la evaluacion de clasificadores. En la parte aplicada, algunos de los algoritmos propuestos son utilizados para resolver dos problemas del area de la biologia, la identificacion de genes asociados a enfermedad y genes involucrados en cancer.
SOBRE LOS FLEBÓTOMOS (DIPTERA: PSYCHODIDAE: PHLEBOTOMINAE), CON ESPECIAL REFERENCIA A LAS ESPECIES CONOCIDAS EN VENEZUELA

Se presenta una revision actualizada sobre aspectos generales de los Flebotomos: importancia medica, identificacion, sistematica y taxonomia, biologia, ecologia y control. Se presta especial atencion a las especies reportadas hasta ahora en Venezuela, de las cuales se provee un catalogo actualizado con 4 especies del genero Brumptomyia y 96 especies del Genero Lutzomyia . Se senalan las especies vectoras de leishmaniasis y su distribucion geografica en el Pais. Se proporciona una extensa literatura de apoyo.