Miracle-dz/UniFAR-FTUs huggingface dataset:
Reassessment of 20th century global mean sea level rise

Significance Estimates of global mean sea level (GMSL) before the advent of satellite altimetry vary widely, mainly because of the uneven coverage and limited temporal sampling of tide gauge records, which track local sea level rather than the global mean. Here we introduce an approach that combines recent advances in solid Earth and geoid corrections for individual tide gauges with improved knowledge about their geographical representation of ocean internal variability. Our assessment yields smaller trends before 1990 than previously reported, leading to a larger overall acceleration; identifies three major explanations for differences with previous estimates; and reconciles observational GMSL estimates with the sum of individually modeled contributions from the Coupled Model Intercomparison Project 5 database for the entire 20th century. The rate at which global mean sea level (GMSL) rose during the 20th century is uncertain, with little consensus between various reconstructions that indicate rates of rise ranging from 1.3 to 2 mm⋅y−1. Here we present a 20th-century GMSL reconstruction computed using an area-weighting technique for averaging tide gauge records that both incorporates up-to-date observations of vertical land motion (VLM) and corrections for local geoid changes resulting from ice melting and terrestrial freshwater storage and allows for the identification of possible differences compared with earlier attempts. Our reconstructed GMSL trend of 1.1 ± 0.3 mm⋅y−1 (1σ) before 1990 falls below previous estimates, whereas our estimate of 3.1 ± 1.4 mm⋅y−1 from 1993 to 2012 is consistent with independent estimates from satellite altimetry, leading to overall acceleration larger than previously suggested. This feature is geographically dominated by the Indian Ocean–Southern Pacific region, marking a transition from lower-than-average rates before 1990 toward unprecedented high rates in recent decades. We demonstrate that VLM corrections, area weighting, and our use of a common reference datum for tide gauges may explain the lower rates compared with earlier GMSL estimates in approximately equal proportion. The trends and multidecadal variability of our GMSL curve also compare well to the sum of individual contributions obtained from historical outputs of the Coupled Model Intercomparison Project Phase 5. This, in turn, increases our confidence in process-based projections presented in the Fifth Assessment Report of the Intergovernmental Panel on Climate Change.
African Highway: The Battle for Health in Central Africa

For most of the period from 1970 to 1986 I worked as a surgeon and health service manager in Zambia and in particular for the mining industry from 1975. In common with most of the residents of the Copperbelt mining district I rather took for granted the fact that we had no need to take malaria prophylaxis. On reflection this was not something we could have expected. My interest in the history of malaria control on the Copperbelt was first raised by sight of correspondence in 1936 from the directors of the Beatty’s mining company in London urging the chief medical officer at the Roan Antelope mine to put more effort into …
Workplace violence: a survey of paediatric residents.

BACKGROUND Paediatric residents are often exposed to verbal abuse and/or physical assaults from patients and patients' families during the course of their training. Residents may benefit from further training on how to prevent and respond to workplace violence. AIMS To determine the prevalence of workplace violence in paediatric residency training programmes. METHODS In 2007, a 25-item web-based questionnaire about experiences of verbal and/or physical abuse while on duty was distributed to 1211 paediatric residents at all training levels from 25 paediatric programmes. RESULTS A total of 541 questionnaires were returned giving a 45% response rate. In total, 33% of the respondents had been verbally abused or physically assaulted by patients and/or patients' families during their residency programme, although verbal abuse was much more common than physical assaults. In total, 71% of respondents reported having no teaching about workplace violence during their residency training. The majority (74%) indicated that they would like to receive more training in managing angry patients and families. CONCLUSIONS Paediatric residents are often exposed to verbal threats during the course of their work. They are also at risk of physical assaults by angry patients and/or families. Paediatric residents require more training on how to prevent and respond to workplace violence, and this important topic should be incorporated into the paediatric residency curriculum.
Coincidence of maternal and fetal QRS complexes in view of fetal heart rate determination

Indirect fetal electrocardiography is a developing diagnostic method in perinatal medicine. Signals of electrical activity being recorded from maternal abdomen surface contain more information than in till now used method of mechanical heart activity measurement based on ultrasound signals. The main problem relies on separation of basic useful component from a signal containing also dominant maternal electrocardiogram and muscles activity artifacts. The algorithms of maternal electrocardiogram suppression via subtraction are commonly used. Although regarding their complexity, these algorithms have limited applicability in systems for long-term monitoring of fetal heart activity. Other solution relies on simple blanking of maternal QRS complexes. However, in case of coincidence of fetal and maternal QRS complexes, this leads to partial loss of information about fetal heart rate variability. For evaluation of how often such coincidence of both complexes takes place, the algorithm has been developed which is described in this paper.
Perceived barriers and facilitators to implement elder abuse intervention for victims and perpetrators: views from US Chinese older adults

Purpose – The purpose of this paper is to explore US Chinese older adults’ views regarding elder abuse interventions in order to understand barriers and facilitators of help-seeking behaviors. Design/methodology/approach – The study design was qualitative, using a grounded theory approach to data collection and analysis. Community-based participatory research approach was implemented to partner with the Chicago Chinese community. A total of 37 community-dwelling Chinese older adults (age 60+) participated in focus group discussions. Findings – Participants viewed many benefits of intervention programs. Perceived barriers were categorized under cultural, social, and structural barriers. Facilitators to implement interventions included increasing education and public health awareness, integrating social support with existing community social services, as well as setting an interdisciplinary team. Perpetrators intervention strategies were also discussed. Originality/value – This study has wide policy and pra.
The effect of atropine on the pulse

It has been shown that, in healthy conscious subjects, the effect of intravenous atropine is a function of the total dose and the rate of administration. Less than about 0.5mg slows the pulse. The effect of larger doses depends on the rate of injection; rapid rates give acceleration only, slow rates give slowing followed by acceleration * 9 2 9 . 3 . Intravenous atropine is often used during anaesthesia for a number of reasons which usually involve an attempt to prevent or treat the occurrence of a dangerously slow pulse rate. A good example is its use to prevent bradycardia when neostipine is used as an antidote to curare-like drugs. It seems important, therefore, to establish whether or not anzsthetised patients behave in the same way as conscious subjects. Previously published work and some unpublished work of my own seems to suggest that they do not. All the authors except one agree that doses of 0.2-1.28mg accelerate the pulse in every case** 3 ~ 4 * 5 ~ 6 9 7 * 8; Rawstrom and Hutchinson9 however noted slowing in 5 out of 44 patients. These authors also noticed that intravenous atropine frequently gave rise to cardiac arrhythmias in anzsthetised patients and that the incidence varied with the anaxthetic agent used. Riding and Robinson 8 emphasised the role of hypoxia and/or hypercarbia in determining the incidence of arrhythmias.
TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation

Significance Genetic studies have identified potential risk factors that have helped elucidate biological pathways involved in the development of Parkinson disease (PD). However, the majority of genome-wide association studies-implicated loci contain multiple genes requiring further investigation to establish the causality of any nominated gene to the pathology of associated disease. Here, we provide functional evidence that deficiency of the lysosomal K+ channel transmembrane protein 175, discovered under the third most-significant PD genome-wide association study peak, is critical for pathogenesis of PD by impairing lysosomal and mitochondrial function. Parkinson disease (PD) is a neurodegenerative disorder pathologically characterized by nigrostriatal dopamine neuron loss and the postmortem presence of Lewy bodies, depositions of insoluble α-synuclein, and other proteins that likely contribute to cellular toxicity and death during the disease. Genetic and biochemical studies have implicated impaired lysosomal and mitochondrial function in the pathogenesis of PD. Transmembrane protein 175 (TMEM175), the lysosomal K+ channel, is centered under a major genome-wide association studies peak for PD, making it a potential candidate risk factor for the disease. To address the possibility that variation in TMEM175 could play a role in PD pathogenesis, TMEM175 function was investigated in a neuronal model system. Studies confirmed that TMEM175 deficiency results in unstable lysosomal pH, which led to decreased lysosomal catalytic activity, decreased glucocerebrosidase activity, impaired autophagosome clearance by the lysosome, and decreased mitochondrial respiration. Moreover, TMEM175 deficiency in rat primary neurons resulted in increased susceptibility to exogenous α-synuclein fibrils. Following α-synuclein fibril treatment, neurons deficient in TMEM175 were found to have increased phosphorylated and detergent-insoluble α-synuclein deposits. Taken together, data from these studies suggest that TMEM175 plays a direct and critical role in lysosomal and mitochondrial function and PD pathogenesis and highlight this ion channel as a potential therapeutic target for treating PD.
Surveillance of Australian workplace Based Respiratory Events (SABRE) in New South Wales.

BACKGROUND The Surveillance of Australian workplace Based Respiratory Events (SABRE) New South Wales (NSW) scheme is a voluntary notification scheme established to determine the incidence of occupational lung diseases in NSW Australia. AIMS Data presented in this paper summarize the last 7 years of reporting to SABRE (June 2001 to December 2008). METHODS Every 2 months, participating occupational physicians, respiratory physicians and general practitioners (accredited by the NSW WorkCover Authority) reported new cases of occupational lung disease seen in their practices. Data collected include gender, age, causal agent and the occupations and industries believed responsible. Estimated incidence was calculated for each disease. RESULTS Three thousand six hundred and fifty-four cases were notified to the scheme, consisting of 3856 diagnoses. Most of the cases were males (76%). Pleural plaques [1218 (28%)] were the most frequently reported condition, followed by mesothelioma [919 (24%)]. Silicosis [90 (2%)] and occupational asthma [OA; 89 (2%)] were the most frequently reported non-asbestos-related diseases. Estimated rates for mesothelioma, diffuse pleural thickening (DPT) and OA were 83, 83 and 5 cases per million employed males per year, respectively. Trades such as carpenters and electricians associated with the building industry, electricity supply and asbestos product manufacture were the most common occupations and industries reported. CONCLUSIONS Asbestos-related diseases are the most frequently reported conditions to SABRE NSW. The very low incidence of OA for NSW most likely reflects under-diagnosis as well as under-reporting. Occupational lung disease is still occurring in NSW despite current preventative strategies. The SABRE scheme currently provides the only available information in this area.
Water‐Rich Biomimetic Composites with Abiotic Self‐Organizing Nanofiber Network

Load‐bearing soft tissues, e.g., cartilage, ligaments, and blood vessels, are made predominantly from water (65–90%) which is essential for nutrient transport to cells. Yet, they display amazing stiffness, toughness, strength, and deformability attributed to the reconfigurable 3D network from stiff collagen nanofibers and flexible proteoglycans. Existing hydrogels and composites partially achieve some of the mechanical properties of natural soft tissues, but at the expense of water content. Concurrently, water‐rich biomedical polymers are elastic but weak. Here, biomimetic composites from aramid nanofibers interlaced with poly(vinyl alcohol), with water contents of as high as 70–92%, are reported. With tensile moduli of ≈9.1 MPa, ultimate tensile strains of ≈325%, compressive strengths of ≈26 MPa, and fracture toughness of as high as ≈9200 J m−2, their mechanical properties match or exceed those of prototype tissues, e.g., cartilage. Furthermore, with reconfigurable, noncovalent interactions at nanomaterial interfaces, the composite nanofiber network can adapt itself under stress, enabling abiotic soft tissue with multiscale self‐organization for effective load bearing and energy dissipation.
African genomes illuminate the early history and transition to selfing in Arabidopsis thaliana

Significance The principal plant model species, Arabidopsis thaliana, is central to our understanding of how molecular variants lead to phenotypic change. In this genome-sequencing effort focused on accessions from Africa, we show that African populations represent the most ancient lineages and provide new clues about the origin of selfing and the species itself. Population history in Africa contrasts sharply with the pattern in Eurasia, where the vast majority of samples result from the recent expansion of a single clade. This previously unexplored reservoir of variation is remarkable given the large number of genomic studies conducted previously in this well-studied species and implies that assaying variation in Africa may often be necessary for understanding population history in diverse species. Over the past 20 y, many studies have examined the history of the plant ecological and molecular model, Arabidopsis thaliana, in Europe and North America. Although these studies informed us about the recent history of the species, the early history has remained elusive. In a large-scale genomic analysis of African A. thaliana, we sequenced the genomes of 78 modern and herbarium samples from Africa and analyzed these together with over 1,000 previously sequenced Eurasian samples. In striking contrast to expectations, we find that all African individuals sampled are native to this continent, including those from sub-Saharan Africa. Moreover, we show that Africa harbors the greatest variation and represents the deepest history in the A. thaliana lineage. Our results also reveal evidence that selfing, a major defining characteristic of the species, evolved in a single geographic region, best represented today within Africa. Demographic inference supports a model in which the ancestral A. thaliana population began to split by 120–90 kya, during the last interglacial and Abbassia pluvial, and Eurasian populations subsequently separated from one another at around 40 kya. This bears striking similarities to the patterns observed for diverse species, including humans, implying a key role for climatic events during interglacial and pluvial periods in shaping the histories and current distributions of a wide range of species.
Synchronous circadian voltage rhythms with asynchronous calcium rhythms in the suprachiasmatic nucleus

Significance The mammalian master circadian clock, the suprachiasmatic nucleus (SCN), contains a network composed of various neuron types. The SCN network plays critical roles in expressing robust circadian rhythms in physiology and behavior, such as sleep–wake cycles. The molecular clock in individual SCN neurons controls membrane excitability, and sends output signals to various organs. However, how the SCN neurons transmit output signals remains unknown. Using a genetically encoded voltage sensor, we directly measured the circadian rhythms of membrane voltage in the SCN network. Remarkably, the circadian voltage rhythms are synchronous across the entire SCN network, whereas simultaneously recorded Ca2+ rhythms are asynchronous in the dorsal and ventral SCN regions. These results indicate that the SCN network produces coherent output signals. The suprachiasmatic nucleus (SCN), the master circadian clock, contains a network composed of multiple types of neurons which are thought to form a hierarchical and multioscillator system. The molecular clock machinery in SCN neurons drives membrane excitability and sends time cue signals to various brain regions and peripheral organs. However, how and at what time of the day these neurons transmit output signals remain largely unknown. Here, we successfully visualized circadian voltage rhythms optically for many days using a genetically encoded voltage sensor, ArcLightD. Unexpectedly, the voltage rhythms are synchronized across the entire SCN network of cultured slices, whereas simultaneously recorded Ca2+ rhythms are topologically specific to the dorsal and ventral regions. We further found that the temporal order of these two rhythms is cell-type specific: The Ca2+ rhythms phase-lead the voltage rhythms in AVP neurons but Ca2+ and voltage rhythms are nearly in phase in VIP neurons. We confirmed that circadian firing rhythms are also synchronous and are coupled with the voltage rhythms. These results indicate that SCN networks with asynchronous Ca2+ rhythms produce coherent voltage rhythms.
Smoking status and immunoglobulin E seropositivity to workplace allergens.

BACKGROUND Detection of serum-specific immunoglobulin E (IgE) can be helpful in the diagnosis of work-related allergic conditions. There have been conflicting reports regarding any association between smoking and specific IgE levels. AIMS To establish whether a relationship exists between smoking status and the outcome of specific IgE tests to workplace allergens. METHODS The Health and Safety Laboratory provides test services for workplace allergens and the request form used collects data on smoking status. Laboratory results of 695 subjects who had undergone specific IgE tests were examined by information on smoking. RESULTS Smokers were more likely than non-smokers to have positive specific IgE tests (P < 0.05). Smoking was the only independent predictor of a positive specific IgE test in logistic regression, with odds ratio of 2.39 (95% confidence interval 1.01-5.65, P < 0.05) for IgE seropositivity. Allergen subgroups also showed a positive association with smoking and in particular for high molecular weight allergens. CONCLUSIONS Being a current smoker is a risk factor for sensitization to workplace allergens especially for those of high molecular weight. Workplace well-being activities may make use of such information for smoking cessation programmes and emphasizing the importance of allergen exposure control. Collaboration between testing laboratories may provide useful datasets for further analysis.
Increased frequencies of T helper type 17 cells in the peripheral blood of patients with acute myeloid leukaemia

T helper type 17 (Th17) cells, which represent a novel subset of CD4+ T cells, play an active role in inflammatory and autoimmune diseases. Recent studies have also suggested that they have an impact on solid tumours. However, the nature of Th17 cells in haematological malignancies remains unknown. In this study, we investigated Th17 cell frequency and secretion of related cytokines in patients with acute myeloid leukaemia (AML). First, we found that Th17 cell frequencies were increased significantly in peripheral blood samples from untreated patients with AML, compared with those from healthy volunteers. Moreover, increased interleukin (IL)‐17 concentrations accompanied the increased Th17 cell frequencies in these patients. These results suggest that Th17 cells may play a role in the pathogenesis of AML. Secondly, we found that the increased Th17 cell frequencies were reduced when patients achieved complete remission after chemotherapy, suggesting that measurement of Th17 cell frequencies may have clinical value in the evaluation of therapeutic effect. In addition, we found that IL‐6 and transforming growth factor (TGF)‐β1 concentrations increased in the untreated patients and that IL‐6 concentrations showed a positive correlation with the frequencies of Th17 cells, suggesting that IL‐6 may play an important role in Th17 cell differentiation in patients with AML.
Protectin D1n-3 DPA and resolvin D5n-3 DPA are effectors of intestinal protection

Significance We provide evidence for a functional role of bioactive lipid mediators of the docosapentaenoic acid (DPA) metabolome in intestinal inflammation. Supported by changes in DPA-derived mediators in colon biopsies from inflammatory bowel diseases, we studied the pharmacological properties of two mediators. Exogenous administration of protectin (PD)1n-3 DPA or resolvin (Rv)D5n-3 DPA in mice reduced dextran sulfate sodium-induced colitis though a mechanism partly linked to decreased leukocyte–endothelial interaction and reduced granulocyte trafficking, as assessed by intravital microscopy. The translational impact of these data was determined by the ability of PD1n-3 DPA and RvD5n-3 DPA to reduce human neutrophil adhesion onto TNF-α–activated human endothelial monolayers. We propose that n-3 DPA-derived mediators could represent the basis for innovative therapeutic strategies in settings of intestinal inflammation. The resolution of inflammation is an active process orchestrated by specialized proresolving lipid mediators (SPM) that limit the host response within the affected tissue; failure of effective resolution may lead to tissue injury. Because persistence of inflammatory signals is a main feature of chronic inflammatory conditions, including inflammatory bowel diseases (IBDs), herein we investigate expression and functions of SPM in intestinal inflammation. Targeted liquid chromatography-tandem mass spectrometry-based metabololipidomics was used to identify SPMs from n-3 polyunsaturated fatty acids in human IBD colon biopsies, quantifying a significant up-regulation of the resolvin and protectin pathway compared with normal gut tissue. Systemic treatment with protectin (PD)1n-3 DPA or resolvin (Rv)D5n-3 DPA protected against colitis and intestinal ischemia/reperfusion-induced inflammation in mice. Inhibition of 15-lipoxygenase activity reduced PD1n-3 DPA and augmented intestinal inflammation in experimental colitis. Intravital microscopy of mouse mesenteric venules demonstrated that PD1n-3 DPA and RvD5n-3 DPA decreased the extent of leukocyte adhesion and emigration following ischemia-reperfusion. These data were translated by assessing human neutrophil–endothelial interactions under flow: PD1n-3 DPA and RvD5n-3 DPA reduced cell adhesion onto TNF-α–activated human endothelial monolayers. In conclusion, we propose that innovative therapies based on n-3 DPA-derived mediators could be developed to enable antiinflammatory and tissue protective effects in inflammatory pathologies of the gut.