Miracle-dz/UniFAR-FTUs huggingface dataset:
Gender differences in preferences of individual and team sports in Polish adolescents

Background: The prevalence of physical activity (PA) depends greatly on the options of executing preferable and favorite PA. Objective information about individual preferences in types of PA can support successful integration of adolescents into regular participation in PA. Defining the role of individual and team sports in regard to girls' and boys' sport preferences is a permanent problem that requires objective and continuous diagnostics. Objective: The purpose of the study is to examine the relationship among girls' and boys' preferences in individual and team sports and further among these preferences and PA participation. Methods: Online research was conducted in the Katowice region and 518 boys and 559 girls from the age of 15 to 17 years participated. All high schools in the region were called on for participation, but only schools that allowed the research examination participated. Sport preferences survey that participants completed online via INDARES system was used to diagnose preferences in individual and team sports. The results were analyzed using basic statistical procedures, the relationship was determined based on rank correlation coefficients and differences between orders of preferred sports were tested by Mann-Whitney test. Results: The most preferred individual sport in girls and boys is swimming, and that applies for all age groups. There is a very strong correlation (rs = .841 - .895; p < .001) among girls' and boys' (15 to 17 years old) preferences in individual sports. Volleyball is the most preferred team sport for girls followed by basketball and handball. The most preferred team sport for boys is soccer by distantly followed by volleyball and basketball. The relationship between girls' and boys' team sports is not as strong as for individual sports (rs = .745 - .763; p < .001). In regard to selected sports, boys and girls corresponded in their team sports preferences followed by individual sports preferences. The highest difference in preferences was evident in the group of Rhythmic and Dancing activities, which were ranked third by girls, while boys ranked them last. Both girls and boys who prefer individual sports and girls who prefer team sports participate longer in hourly range of organized PA. Conclusions: The Polish version of the online system INDARES is a suitable diagnostic tool for the examination of sport preferences sphere in adolescents. Understanding gender differences in sport preferences of adolescents can increase their participation in organized PA.
Using Semantic Web technologies in the development of data warehouses: A systematic mapping

The exploration and use of Semantic Web technologies have attracted considerable attention from researchers examining data warehouse (DW) development. However, the impact of this research and the maturity level of its results are still unclear. The objective of this study is to examine recently published research articles that take into account the use of Semantic Web technologies in the DW arena with the intention of summarizing their results, classifying their contributions to the field according to publication type, evaluating the maturity level of the results, and identifying future research challenges. Three main conclusions were derived from this study: (a) there is a major technological gap that inhibits the wide adoption of Semantic Web technologies in the business domain;(b) there is limited evidence that the results of the analyzed studies are applicable and transferable to industrial use; and (c) interest in researching the relationship between DWs and Semantic Web has decreased because new paradigms, such as linked open data, have attracted the interest of researchers.
Effect of Lifestyle Modification Intervention on Health Status of Coronary Artery Disease Patients: Randomized Control Trial

Background: Coronary artery disease is a major cause of morbidity and mortality throughout the world. Modification of life style can be achieved by patients' education to improve their health status. Aim: To evaluate effect of lifestyle modification intervention on health status of coronary artery disease patients. Design: Randomized control trial used to achieve the aim of this study. Setting: The current study conducted at the coronary care unit and cardiology out-patient clinics of Benha University Hospital, Benha City. Subjects: Purposive sample of 92 coronary artery disease patients (study and control) were included in the study. Tools: Two tools used in this study 1) Interview questionnaire. 2) Health status questionnaire. Results: Significant percentage of the study participants from both groups were adhered to unhealthy life-style practices as smoking, eating salty and fatty foods, drinking tea and coffee as well as they didn't practice exercises and recreational activities. After lifestyle modification intervention, there were significant statistical differences between the two groups favoring the study group regarding all aspects of health status; physical function, bodily pain, social function, role limitation due to physical or emotional problems and mental health (P<0.05). Conclusion and recommendations: This study concluded that life style modification intervention for coronary artery disease patients is effective and useful for enhancing their health status. This study recommended that coronary artery patients` education should be held in permanent approach, because it is a crucial part of their treatment.
Student Worksheet in Mathematical Creative Thinking

This study aimed to develop student worksheet on a calculus with APOS to improve mathematical creative thinking. The development model includes: identifying learning objectives, conducting learning analyzes, formulating specific objectives, developing assessment instruments, developing learning strategies, developing and selecting learning materials, designing and executing evaluation, revising learning materials, designing and carry out evaluation. The research is done by validating the student worksheet on calculus with APOS and the subject of the test was the mathematics education student. The results show that the trial of student worksheets on the calculus with APOS showed very good and very effective results and appropriate to be used in learning. This is because the student worksheet got positive responses from student and learning by using student worksheet is very interesting and students understand the calculus material more easily and student’s ability of mathematical creative thinking improved with 83% achievement. The student worksheets on the calculus material with APOS has impact on the student's academic ability which has improved very well.
Naive cynicism in everyday theories of responsibility assessment : On biased assumptions of bias

Evidence from several lab and field studies is presented that indicates that people have cynical intuitions about how others assess responsibility. Married couples (Study 1), video game enthusiasts (Study 2), debaters (Study 3), and darts players (Study 4) divided responsibility for a series of desirable and undesirable joint outcomes and estimated how others would apportion responsibility. In all studies, participants expected the responsibility allocations of others-but not their own-to be motivationally biased. This was true regardless of whether responsibility assessments actually were biased. In Studies 3 and 4, participants assumed that their teammates would be less biased than their opponents, suggesting that factors known to influence motivation can moderate the strength of this naive cynicism.
Procedural Justice in Performance Evaluation: The Role of Instrumental and Non-Instrumental Voice in Performance Appraisal Discussions

This study examined the role of subordinate voice in creating positive attitudes in the performance appraisal context. Two aspects of voice, instrumental and non-instrumental, were assessed. Both aspects of voice were related to satisfaction with the appraisal, while only non-instrumental voice had an impact on attitudes toward the manager. Implications for procedural justice and performance appraisal are discussed.
A Furcated Visual Collision Avoidance System for an Autonomous Microrobot

This paper proposes a secondary reactive collision avoidance system for microclass of robots based on a novel approach known as the furcated luminance-difference processing (FLDP) inspired by the lobula giant movement detector, a wide-field visual neuron located in the lobula layer of a locust nervous system. This paper addresses some of the major collision avoidance challenges: obstacle proximity and direction estimation, and operation in GPS-denied environment with irregular lighting. Additionally, it has proven effective in detecting edges independent of background color, size, and contour. The FLDP executes a series of image enhancement and edge detection algorithms to estimate collision threat-level which further determines whether the robot’s field of view must be dissected where each section’s response is compared against the others to generate a simple collision-free maneuver. Ultimately, the computation load and the performance of the model are assessed against an eclectic set of offline as well as real-time real-world collision scenarios validating the proposed model’s asserted capability to avoid obstacles at more than 670 mm prior to collision, moving at 1.2 ms−1 with a successful avoidance rate of 90% processing at 120 Hz on a simple single-core microcontroller, sufficient to conclude the system’s feasibility for real-time real-world applications that possess fail-safe collision avoidance system.
Individuation, counting, and statistical inference: The role of frequency and whole-object representations in judgment under uncertainty

Evolutionary approaches to judgment under uncertainty have led to new data showing that untutored subject reliably produce judgments that conform to may principles of probability theory when (a) they are asked to compute a frequency instead of the probability of a single event, and (b) the relevant information is expressed as frequencies. But are the frequencycomputation systems implicated in these experiments better at operating over some kinds of input than others? Principles of object perception and principles of adaptive design led us to propose the individuation hypothesis : that these systems are designed to produce wellcalibrated statistical inferences when they operate over representations of “whole” objects, events, and locations. In a series of experiments on Bayesian reasoning, we show that human performance can be systematically improved or degraded by varying whether a correct solution requires one to compute hit and false-alarm rates over “natural” units, such as whole objects, as opposed to inseparable aspects, views, and other parsings that violate evolved principles of object construal. The ability to make well-calibrated probability judgments depends, at a very basic level, on the ability to count. The ability to count depends on the ability to individuate the world: to see it as composed of discrete entities. Research on how people individuate the world is, therefore, relevant to understanding the statistical inference mechanisms that govern how people make judgments under uncertainty. Computational machinery whose architecture is designed to parse the world and make inferences about it is under intensive study in many branches of psychology: perception, psychophysics, cognitive development, cognitive neurosci
Increasing Rates of School Completion: Moving from Policy and Research to Practice (NCSET Teleconference)

A transcript summarizing a teleconference on the magnitude of the dropout problem, especially in relation to students with disabilities, what we know with regard to key concepts in understanding dropout, who is at increased risk of dropout, understanding why students drop out of school, and what we should focus on in order to keep kids in school.
Proton pump inhibitors regulate metabolic profile and glycaemic indices in patients with type 2 diabetes mellitus: A rising dawn of a new therapeutic concept.

Objective To evaluate the effect of proton pump inhibitors on glycaemic indices in patients with type 2 diabetes mellitus. Methods The case-control study was conducted at the National Diabetes Centre, Mustansiriyah University, Baghdad, Iraq, from January to April 2018, and comprised type 2 diabetes patients and non-diabetic healthy controls. The subjects were divided into three groups: Group A had controls on proton pump inhibitors; Group B had patients treated with metformin 850 g/day; and Group C had patients treated with metformin 850 g/day plus proton pump inhibitors. Gastrin serum levels, lipid profile, glycaemic indices and blood pressure changes were measured in the groups. Data was analysed using SPSS 20. Results Of the 100 subjects, 60(60%) were patients with a mean age of 54.98}4.22 years, while40(40%) were controls with a mean age of 50.69}4.34 years. Group A had 40(40%) subjects, while Group B and Group C had 30(30%) each. Proton pump inhibitors improved glycaemic indices and lipid profile in the patients 9p<0.05) while increasing gastrin serum levels which were significantly correlated with reduction in glycated haemoglobin, fasting blood glucose and augmentation of β-cell function (p<0.05 each). Conclusions Proton pump inhibitors improved glycemic indices and metabolic profile in type 2 diabetes patients via augmentation of gastrin serum levels.
Immune cell infiltration as a biomarker for the diagnosis and prognosis of digestive system cancer

The digestive system cancers are aggressive cancers with the highest mortality worldwide. In this study, we undertook a systematic investigation of the tumor immune microenvironment to identify diagnostic and prognostic biomarkers. The fraction of 22 immune cell types of patients were estimated using CIBERSORT. The least absolute shrinkage and selection operator (LASSO) analysis was carried out to identify important immune predictors. By comparing immune cell compositions in 801 tumor samples and 46 normal samples, we constructed the diagnostic immune score (DIS), showing high specificity and sensitivity in the training (area under the receiver operating characteristic curve [AUC] = 0.929), validation (AUC = 0.935), and different cancer type cohorts (AUC > 0.70 for all). We also established the prognostic immune score (PIS), which was an effective prognostic factor for relapse‐free survival in training, validation, and entire cohorts (P < .05). In addition, PIS provided a higher net benefit than TNM stage. A composite nomogram was built based on PIS and patients' clinical information with well‐fitted calibration curves (c‐index = 0.84). We further used other cohorts from Gene Expression Omnibus databases and obtained similar results, confirming the reliability and validity of the DIS and PIS. In addition, the unsupervised clustering analysis using immune cell proportions revealed 6 immune subtypes, suggesting that the immune types defined as having relatively high levels of M0 or/and M1 macrophages were the high‐risk subtypes of relapse. In conclusion, this study comprehensively analyzed the tumor immune microenvironment and identified DIS and PIS for digestive system cancers.
Phosphorylation of the amyloid precursor protein (APP) at Ser-675 promotes APP processing involving meprin β

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by abnormal deposition of β-amyloid (Aβ) peptides. Aβ is a cleavage product of the amyloid precursor protein (APP), and aberrant posttranslational modifications of APP can alter APP processing and increase Aβ generation. In the AD brain, seven different residues, including Ser-675 (APP695 numbering) in the APP cytoplasmic domain has been found to be phosphorylated. Here, we show that expression of a phosphomimetic variant of Ser-675 in APP (APP-S675E), in human neuroblastoma SK-N-AS cells, reduces secretion of the soluble APP ectodomain (sAPPα), even though the total plasma membrane level of APP was unchanged compared with APP levels in cells expressing APPwt or APP-S675A. Moreover, the level of an alternative larger C-terminal fragment (CTF) increased in the APP-S675E cells, whereas the CTF form that was most abundant in cells expressing APPwt or APP-S675A decreased in the APP-S675E cells. Upon siRNA-mediated knockdown of the astacin metalloprotease meprin β, the levels of the alternative CTF decreased and the CTF ratio was restored back to APPwt levels. Our findings suggest that APP–Ser-675 phosphorylation alters the balance of APP processing, increasing meprin β–mediated and decreasing α-secretase–mediated processing of APP at the plasma membrane. As meprin β cleavage of APP has been shown to result in formation of highly aggregation-prone, truncated Aβ2–40/42 peptides, enhanced APP processing by this enzyme could contribute to AD pathology. We propose that it would be of interest to clarify in future studies how APP–Ser-675 phosphorylation promotes meprin β–mediated APP cleavage.
Adjunctive host-directed therapy with statins improves tuberculosis-related outcomes in mice.

BACKGROUND Tuberculosis (TB) treatment is lengthy and complicated and patients often develop chronic lung disease. Recent attention has focused on host-directed therapies aimed at optimizing immune responses to M. tuberculosis (Mtb), as adjunctive treatment given with anti-tubercular drugs. In addition to their cholesterol-lowering properties, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) have broad anti-inflammatory and immunomodulatory activities. METHODS In the current study, we screened 8 commercially available statins for cytotoxic effect, anti-tubercular activity, synergy with first-line drugs in macrophages, pharmacokinetics and adjunctive bactericidal activity, and, in two different mouse models, as adjunctive therapy to first-line TB drugs. RESULTS Pravastatin showed the least toxicity in THP-1 and Vero cells. At non-toxic doses, atorvastatin and mevastatin were unable to inhibit Mtb growth in THP-1 cells. Simvastatin, fluvastatin and pravastatin showed the most favorable therapeutic index, and enhanced the anti-tubercular activity of the first-line drugs isoniazid, rifampin and pyrazinamide in THP-1 cells. Pravastatin modulated phagosomal maturation characteristics in macrophages, phenocopying macrophage activation, and exhibited potent adjunctive activity in the standard mouse model of TB chemotherapy and in a mouse model of human-like necrotic TB lung granulomas. CONCLUSION These data provide compelling evidence for clinical evaluation of pravastatin as adjunctive, host-directed therapy for TB.
Pistacia Genus as a Potential Source of Neuroprotective Natural Products

Abstract Neuroprotective agents are able to defend the central nervous system against acute or chronic neuronal injuries. Even with the progress made over the last decades, most of the medications prescribed for the management of neurodegenerative diseases can only reduce their symptoms and slow down their progression. Based on natural product research, there are potential effective medicinal plants and phytochemicals for modulating neuronal functions and protecting against neurodegeneration. Plants in the genus Pistacia are also among valuable natural resources for neuroprotection research based on experiences in traditional medicine. Studies have supported the value of bioactive compounds of the genus Pistacia for central nervous system disorders such as Alzheimerʼs, Parkinsonʼs, multiple sclerosis, cerebral ischemia, depression, and anxiety. Related literature has also revealed that most of the evidence on neuroprotection in the genus Pistacia is in the form of preliminary studies, mainly including models of behavior, motor function, and memory impairments in animals, neural toxicity, cerebral ischemia and seizure models, evaluation of their effects on antioxidant and inflammatory biomarkers, amyloid β aggregation, and acetylcholinesterase as well as investigations into some cellular pathways. Along with the phytonutrients in kernels such as pistachios, various phytochemicals, mostly terpenes, and phenolic compounds have also been identified in different plant parts, in particular their oleoresins, of species in the genus Pistacia. In this review, the pharmacology of neurological effects and related molecular mechanisms of the plants belonging to the genus Pistacia and its active constituents, as well as pharmacokinetics aspects, are discussed.
Novel biallelic variants in MSTO1 associated with mitochondrial myopathy

Mitochondrial disorders are caused by nuclear and mitochondrial pathogenic variants leading to defects in mitochondrial function and cellular respiration. Recently, the nuclear-encoded mitochondrial fusion gene MSTO1 (Misato 1) has been implicated in mitochondrial myopathy and ataxia. Here we report on a 30-yr-old man presenting with a maternally inherited NM_018116. 3:c.651C>G, p.F217L missense variant as well as a paternally inherited arr[GRCh37] 1q22(155581773_155706887) × 1 deletion encompassing exons 7–14 of MSTO1. His phenotype included muscle weakness, hypotonia, early motor developmental delay, pectus excavatum, and scoliosis. Testing revealed elevated plasma creatine kinase, and electromyogram results were consistent with longstanding generalized myopathy. These phenotypic features overlap well with previously reported patients harboring biallelic MSTO1 variants. Additionally, our patient presents with dysphagia and restrictive lung disease, not previously reported for MSTO1-associated disorders. The majority of patients with disease-associated variants in MSTO1 present with biallelic variants suggesting autosomal recessive inheritance; however, one family has been reported with a single variant and presumed autosomal dominant inheritance. The pattern of inheritance we observed is consistent with the majority of previous reports suggesting an autosomal recessive disorder. We add to our knowledge of the syndrome caused by variants in MSTO1 and provide additional evidence supporting autosomal recessive inheritance. We also describe phenotypic features not reported in previous cases, although further research is needed to confirm they are associated with defects in MSTO1.
Overexpression of UDP-glycosyltransferase potentially involved in insecticide resistance in Aphis gossypii Glover collected from Bt cotton fields in China.

BACKGROUN The cotton aphid, Aphis gossypii Glover is one of the most destructive insect pests. It has evolved resistance to numerous insecticides around the world due to the application of insecticides. UDP-glycosyltransferases (UGTs) have been reported to potentially facilitate the detoxification process of imidacloprid and thiamethoxam in A. gossypii. RESULTS In this study, the field populations of A. gossypii developed different levels of resistance to multiple insecticides. An UGTs inhibitor, 5-nitrouracil, dramatically increased the toxicity of acetamiprid in resistant populations, moderately increased the toxicity of sulfoxaflor in IMI_S, SXYC, and HBJZ populations, and increased the toxicity of bifenthrin in IMI_S and HBJZ populations, butnosynergismon the toxicities of omethoate and carbosulfan. The quantitative real-time PCR analysisrevealed that UGT344B4 and UGT344C7 were overexpressed in all field populations, and UGT344N4 was overexpressed in SDBZ and HBZJ populations. Furthermore, the suppression of UGT344B4 or UGT344C7 by RNAi significantly increased the susceptibility to bifenthrin in IMI_S population, and the susceptibilityto sulfoxaflor in SXYC population. CONCLUSION These results suggested that UGTs werepotentially involved in the detoxification of neonicotinoid, sulfoximine, and pyrethroid insecticides in A. gossypii. Furthermore, the overexpression of UGTs could be associated with insecticide resistance in field population of A. gossypii.The results might be helpful for the management of insecticide resistance in field populations of A. gossypii. This article is protected by copyright. All rights reserved.