Miracle-dz/UniFAR-FTUs huggingface dataset:
Neural microvascular pericytes contribute to human adult neurogenesis

Consistent adult neurogenic activity in humans is observed in specific niches within the central nervous system. However, the notion of an adult neurogenic niche is challenged by accumulating evidence for ectopic neurogenic activity in other cerebral locations. Herein we interface precision of ultrastructural resolution and anatomical simplicity of accessible human dental pulp neurogenic zone to address this conflict. We disclose a basal level of adult neurogenic activity characterized by glial invasion of terminal microvasculature followed by release of individual platelet‐derived growth factor receptor‐β mural pericytes and subsequent reprogramming into NeuN+ local interneurons. Concomitant angiogenesis, a signature of adult neurogenic niches, accelerates the rate of neurogenesis by amplifying release and proliferation of the mural pericyte population by ≈10‐fold. Subsequent in vitro and in vivo experiments confirmed gliogenic and neurogenic capacities of human neural pericytes. Findings foreshadow the bimodal nature of the glio‐vascular assembly where pericytes, under instruction from glial cells, can stabilize the quiescent microvasculature or enrich local neuronal microcircuits upon differentiation.
A Survey of LoRaWAN for IoT: From Technology to Application

LoRaWAN is one of the low power wide area network (LPWAN) technologies that have received significant attention by the research community in the recent years. It offers low-power, low-data rate communication over a wide range of covered area. In the past years, the number of publications regarding LoRa and LoRaWAN has grown tremendously. This paper provides an overview of research work that has been published from 2015 to September 2018 and that is accessible via Google Scholar and IEEE Explore databases. First, a detailed description of the technology is given, including existing security and reliability mechanisms. This literature overview is structured by categorizing papers according to the following topics: (i) physical layer aspects; (ii) network layer aspects; (iii) possible improvements; and (iv) extensions to the standard. Finally, a strengths, weaknesses, opportunities and threats (SWOT) analysis is presented along with the challenges that LoRa and LoRaWAN still face.
Advances in the Diagnosis of GERD Using the Esophageal pH Monitoring, Gastro-Esophageal Impedance-pH Monitoring, And Pitfalls

PH monitoring is not capable of detecting all types of reflux, especially when the amount of acid is very low or not at all in the refluxate. Multichannel intraluminal impedance-pH monitoring (MII-pH) is used as a new method to assess bolus transport. The types of reflexes including acid, weak acid and weak alkaline MII-pH is capable of distinguishing more reflux episodes based upon use of physical and chemical parameters of the refluxate, leads to a diagnosis of normal acid reflux from abnormal nonacidic reflux. 24-h oesophagal pH monitoring can be effectively used to assess the potential relationship between symptoms and refluxes. MII-pH is capable of distinguishing more reflux episodes based upon use of physical and chemical parameters of the refluxate, leads to a diagnosis of normal acid reflux from abnormal nonacidic reflux. It can be used to confirm gastro-oesophagal reflux episodes, where has a sensitivity and specificity for diagnosing GERD in comparison with endoscopy or pH-metry.
Pixel-Anchor: A Fast Oriented Scene Text Detector with Combined Networks

Recently, semantic segmentation and general object detection frameworks have been widely adopted by scene text detecting tasks. However, both of them alone have obvious shortcomings in practice. In this paper, we propose a novel end-to-end trainable deep neural network framework, named Pixel-Anchor, which combines semantic segmentation and SSD in one network by feature sharing and anchor-level attention mechanism to detect oriented scene text. To deal with scene text which has large variances in size and aspect ratio, we combine FPN and ASPP operation as our encoder-decoder structure in the semantic segmentation part, and propose a novel Adaptive Predictor Layer in the SSD. Pixel-Anchor detects scene text in a single network forward pass, no complex post-processing other than an efficient fusion Non-Maximum Suppression is involved. We have benchmarked the proposed Pixel-Anchor on the public datasets. Pixel-Anchor outperforms the competing methods in terms of text localization accuracy and run speed, more specifically, on the ICDAR 2015 dataset, the proposed algorithm achieves an F-score of 0.8768 at 10 FPS for 960 x 1728 resolution images.
Glomerular Hyperfiltration: An Early Marker of Nephropathy in Fabry Disease

Background and objectives: Progressive nephropathy is one of the main features of Fabry disease (FD). It has been supposed that an early phase, clinically silent disease occurs in childhood and adolescence and is characterized by glomerular hyperfiltration (HF). Surprisingly, although HF has been reported in several studies, its prevalence is at present unknown. The focus of our study was to determine the prevalence of HF in a cohort of patients with FD and to identify the factors associated with a high risk of HF. Methods: To address this issue, a retrospective observational study of 87 patients with genetically confirmed FD was performed. HF was defined as an estimated glomerular filtration rate (eGFR) > 130 mL/min/1.73 m2 corrected for age (> 40 years: –1 mL/min/1.73 m2/year). Results: HF occurred in 21 patients (24% of our population), and increased to 50% when only young adults were considered. Hyperfiltrating patients were younger and had lower proteinuria levels than those without HF. The prevalence of cardiovascular and other manifestations of FD was significantly lower in hyperfiltering patients. Conclusions: Our study showed a negative correlation between eGFR and age, and with proteinuria levels and the presence of cardiovascular and other manifestations of FD. These data favor the view that HF in Fabry patients could be related predominantly to a predisease state. Even in the absence of a “measured” GFR, HF should be regarded as an early marker of Fabry nephropathy, and its recognition and confirmation by true GFR seems a relevant feature to address the issue of the potential benefit of nephroprotective treatments at the early stage of Fabry nephropathy.
Comprehensive Health Literacy and Health-Related Behaviors Within a General Japanese Population: Differences by Health Domains

The present study aimed to explore how different health-related domains of health literacy, as measured by the European Health Literacy Survey Questionnaire, were associated with health-related behaviors among a general population in Japan. We conducted a cross-sectional observational study of 1002 Japanese residents. Our questionnaire addressed socioeconomic status, health status, health-related behaviors, and health literacy. Among the 3 health-related domains of health literacy (health care, disease prevention, and health promotion), a multivariate model revealed that the disease prevention domain was associated with exercise behavior and alcohol consumption. The health promotion domain was associated with dietary behavior and exercise behavior. There were strong correlations among all health-related domains of health literacy; however, there were different associations between health literacy and health-related behaviors depending on those domains. Additional research is needed to determine how and to what extent each domain of health literacy is related to what health behaviors and outcomes.
Emotional Androgyny: A Preventive Factor of Psychosocial Risks at Work?

Although previous studies have acknowledged the connections between gender and emotional competences, more research is needed on how gender and emotion interact to influence psychosocial risks at work. This paper addresses how gender stereotypes and emotions simultaneously act as psychosocial antecedents of organizational stress. Following the principles of psychological androgyny, we propose that a combination of communion and agency can serve as a preventive factor at work and lead to healthier responses by providing a wider range of emotional competences to deal with organizational demands. Following previous methodological approaches, we include a quantitative review about scientific research on occupational health in the PsycINFO database during the period 1980–2017 from a multidimensional gender perspective that differentiates between studies addressing the topic from either sex, gender or gender identity dimensions. Finally, we propose new analytical directions to deal with psychosocial hazards at work by underscoring some of the complex ways in which gender and emotional competences influence psychosocial risks at work.
Experiences of school health nurses regarding the provision of the school health service delivery in the Tshwane district

Background Irrespective of the provision of an integrated school health policy, the school health nurses continue to experience multiple challenges regarding the provisioning of school health service delivery. Aim The aim of this paper was to explore and describe the experiences of school health nurses regarding school health service delivery in the Tshwane district. Setting Schools in the Tshwane district in Pretoria were used in the study. Methods A qualitative and descriptive phenomenological design was used to conduct the study. Purposive sampling techniques were used to select a sample from the population of school health nurses employed in the Tshwane district and conduct the enquiry because of their knowledge and experience of school health services. The researchers collected data by means of unstructured, one-on-one in-depth interviews. The Tesch data analysis method was used by the researcher and co-coder. The researcher identified categories, subcategories and themes and these were reduced into grouping topics that were related to one another. Results Positive and negative experiences of school health nurses emerged. It was evident from the findings of the study that the factors affecting the quality of the integrated school health programme (ISHP) provided were interrelated. Most of these factors negatively affected service delivery. Conclusion It was recommended that the partnership between the National Department of Health and National Department of Basic Education as the main role players should be sustained at all times to ensure the successful implementation of the ISHP.
RSL3 Drives Ferroptosis Through GPX4 Inactivation and ROS Production in Colorectal Cancer

Ferroptosis is an iron-dependent, oxidative cell death, and is characterized by iron-dependent accumulation of reactive oxygen species (ROS) within the cell. It has been implicated in various human diseases, including cancer. Recently, ferroptosis, as a non-apoptotic form of cell death, is emerging in specific cancer types; however, its relevance in colorectal cancer (CRC) is unexplored and remains unclear. Here, we showed that ferroptosis inducer RSL3 initiated cell death and ROS accumulation in HCT116, LoVo, and HT29 CRC cells over a 24 h time course. Furthermore, we found that ROS levels and transferrin expression were elevated in CRC cells treated with RSL3 accompanied by a decrease in the expression of glutathione peroxidase 4 (GPX4), indicating an iron-dependent cell death, ferroptosis. Overexpression GPX4 resulted in decreased cell death after RSL3 treatment. Therefore, RSL3 was able to induce ferroptosis on three different CRC cell lines in vitro in a dose- and time-dependent manner, which was due to increased ROS and an increase in the cellular labile iron pool. Moreover, this effect was able to be reversed by overexpression of GPX4. Taken together, our results suggest that the induction of ferroptosis contributed to RSL3-induced cell death in CRC cells and ferroptosis may be a pervasive and dynamic form of cell death for cancer treatment.
Value of rapid on-site evaluation for ultrasound-guided thyroid fine needle aspiration

Objective Application of rapid on-site evaluation (ROSE) for thyroid fine needle aspiration (FNA) is controversial. Therefore, ROSE has not been universally applied. This study aimed to evaluate the value of ROSE for ultrasound-guided thyroid FNA. Methods A total of 997 patients with 1103 suspicious thyroid nodules had ultrasound-guided FNA performed from January 2016 to February 2018. There were 513 nodules with ROSE and 590 nodules without ROSE. The cytological nondiagnostic rate, needle passes, and procedural times of thyroid FNA with or without ROSE were compared. The nondiagnostic rates of subsets of suspicious thyroid nodules were further compared. Results There was no significant effect of ROSE on the nondiagnostic rate of FNA. However, FNA with ROSE significantly reduced the numbers of sub-centimeter, mixed solid-cystic, macrocalcified, and hypervascular nodules. There was a significantly smaller number of needle passes and less procedural times with ROSE than without ROSE. There was no significant difference in the complication rate of FNA with and without ROSE. Conclusion ROSE for thyroid FNA reduces the number of needle passes and procedural times. ROSE has a higher clinical application value in subsets of thyroid nodules, which tend to be difficult to diagnose with FNA.
Middle School Learners' Conceptions of Social Networks: Results of an Interview Study

Social networks are widely and increasingly used by youths. Thereby, they experience various computing-related phenomena (such as recommendations for new contacts or interesting content), which might require further explanation. From conception research in science education it is known that such everyday experiences can lead to the formation of individual explanations and conceptions, which do not necessarily have to be in line with underlying scientific concepts. Incomplete or wrong conceptions can lead to difficulties in future learning processes. Therefore, the description and analysis of such conceptions is relevant for computing education, because they can be used by teachers for the development of student-centered classroom activities. Since social network systems are complex computing systems, the investigation of student conceptions had to be limited to selected aspects to keep the study manageable. Therefore, in the study described in this paper, middle school learners' perspectives of personal data processing, data storage and algorithmic processes in social networks were investigated based on the model of educational reconstruction. A total of eight semi-structured interviews with 12 to 14 years-old learners from two grammar schools in North Rhine-Westphalia, West Germany, were conducted using an interview guide that focused on the abovementioned computing-related aspects of social networks. The interviews were transcribed and analyzed using the method of qualitative content analysis according to Mayring. As a result, a number of conceptions could be identified, which were anchored in the technical concepts, but of ten superficial and quite general.
Öğrenci Gözüyle Geçmişten Günümüze Türk Eğitim Sistemi

Bu arastirmanin amaci, Egitim Fakultesi Rehberlik ve Psikolojik Danismanlik Anabilim Dali ogrencilerinin goruslerine dayali olarak toplumsal ve politik kosullarin Turk Egitim Sistemi uzerindeki etkisini tarihsel bir bakis acisiyla ortaya cikarmaktir. Arastirma nitel arastirma yontemiyle tasarlanmistir. Arastirmanin calisma grubunu Bayburt Egitim Fakultesi Rehberlik ve Psikolojik Danismanlik Anabilim Dali’nda ogrenim goren 139 ogrenci olusturmaktadir. Ogrencilerin goruslerini ortaya cikarmak icin veri toplama araci olarak arastirmaci tarafindan hazirlanan gorusme formu kullanilmistir. Gorusme formlarindan elde edilen nitel verilerin analizinde icerik analizi kullanilmistir. Egitimin tarihsel gelisimi dikkate alindiginda ogrencilerin toplumsal ve politik kosullarin egitim sistemini etkiledigini dusundukleri ortaya cikmistir. Gunumuz egitim sisteminin sorunlarinin kaynagi olarak da egitim sisteminin kendisini, siyaseti ve degisimleri gormektedirler.
Primary intraosseous squamous cell carcinoma of the mandible: a case with atypical imaging features

Primary intraosseous squamous cell carcinoma is a rare malignant tumour that exclusively arises within the jaws. Its diagnosis requires an appropriate clinical, imaging and histological correlation. The exclusion of primary oral mucosa lesions and metastatic disease is mandatory. We report an atypical imaging appearance of this uncommon entity, characterized by new bone formation and periosteal reaction that resemble sarcomatous or malignant odontogenic tumours. A comprehensive discussion on the embryological principles of primary intraosseous squamous cell carcinoma is also provided.
The Embodied Self, the Pattern Theory of Self, and the Predictive Mind

Do we have to presuppose a self to account for human self-consciousness? If so, how should we characterize the self? These questions are discussed in the context of two alternatives, i.e., the no-self position held by Metzinger (2003, 2009) and the claim that the only self we have to presuppose is a narrative self (Dennett, 1992; Schechtman, 2007; Hardcastle, 2008) which is primarily an abstract entity. In contrast to these theories, I argue that we have to presuppose an embodied self, although this is not a metaphysical substance, nor an entity for which stable necessary and jointly sufficient conditions can be given. Self-consciousness results from an integration of an embodied, basic affective flow with an intentional object (the self as agent or as center of imagination or thought), where this integration remains anchored in an embodied self. This embodied self is a flexible and variable entity, which we can account for only with a pattern theory of the self (in line with Gallagher, 2013). Furthermore, I outline how this pattern theory of the self fits into the predictive coding framework, which also answers the open question whether self-representation is prior to world-representation or the other way around. The principal organization of a mechanism of building up a self-model is such that both types of representations are always activated and developed in parallel. Modeling oneself is a process which is always activated when one interacts with the world – much as a shadow is present when a person walks in the sun.
Low titer A plasma in three AB patients for therapeutic plasma exchange

Currently, low titer A plasma is used on a routine basis in bleeding trauma patients of unknown AB type. Three AB non‐bleeding apheresis patients are presented here who safely received a combination of AB and low titer A plasma during therapeutic plasma exchange (TPE). One control AB patient received AB plasma only.
Alternative digestion approaches improve histone modification mapping by mass spectrometry in clinical samples

Profiling histone posttranslational modifications (PTMs) in clinical samples holds great potential for the identification of epigenetic biomarkers and the discovery of novel epigenetic targets. MS‐based approaches to analyze histone PTMs in clinical samples usually rely on SDS‐PAGE separation following histone enrichment in order to eliminate detergents and further isolate histones. However, this limits the digestions options and hence the modification coverage.
Urinary Exosome-Derived microRNAs Reflecting the Changes in Renal Function in Cats

Increased incidence of kidney disease (KD) is a common concern in human and companion animals. Cats, in particular, are highly susceptible to KD. Novel KD biomarkers would help to address these problems. Therefore, we are focusing on microRNA, a highly conserved nucleic acid, as a KD biomarker for various animals. We previously reported that altered levels of urinary exosome (UExo)-derived microRNAs indicate renal pathologies in dogs. This study comprehensively examined UExo-derived microRNAs, which reflected the KD status in cats. The examined cats were divided into two groups: normal renal function (NR) and KD. Based on our previous data in dogs and cats, as well as the present data on UExo-derived microRNAs in cats by next-generation sequencing, let-7b, let-7f, miR-10a, miR-10b, miR-21a, miR-22, miR-26a, miR-27b, miR-146a, miR-181a, miR-191, and miR-486a were identified as biomarker candidates. In summary, the levels of UExo-derived let-7b, miR-22, and miR-26a significantly decreased in cats with KD from the early stages of the disease. UExo-derived miRNA levels normalized to urinary creatinine or total RNA of miR-21a was significantly higher in the KD group. Importantly, the ratio of UExo-derived miR-21a to let-7b showed a significant and strongest correlation with serum creatinine (ρ = 0.751), blood urea nitrogen (ρ = 0.754), and urinary creatinine (ρ = −0.421) among all examined indices. Further, the ratio of miR-181a to let-7b or miR-10b significantly correlated with the progression of renal dysfunction in the KD group. Thus, we identified that UExo-derived microRNAs in cats, and their raw and normalized levels could indicate altered renal function.
Weight up? Changes in children's anthropometry from time of referral to baseline assessment for paediatric weight management.

Objectives To examine children's wait time to access a multidisciplinary, tertiary-level weight management clinic and assess anthropometric changes from time of referral to baseline assessment. Method A retrospective medical record review was completed of children (5 to 17 years) enrolled in a multidisciplinary, tertiary-level paediatric weight management clinic from 2006 to 2015. Children's demographic and anthropometric data from their referral to and baseline assessment at the clinic were retrieved from medical records. Based on changes in body mass index (BMI) z-score from the time of referral to baseline assessment, children were categorized as decreasers (>0.05 unit decrease), increasers (>0.05 unit increase) or stabilizers (-0.05 to 0.05 unit change). The proportion of children with a ≥0.25 unit BMI z-score reduction was calculated. Analysis of variance and chi-squared tests were performed. Results Children (n=400) were 11.7 ± 2.9 years old at the time of referral, 52.8% (n=211) female, and had an average wait time of 4.5 ± 3.9 months. By 3 and 6 months postreferral, 44.0% (n=176) and 80.8% (n=323), respectively, had attended baseline assessments. Based on BMI z-score change, children were classified as decreasers (n=183; 45.8%), increasers (n=118; 29.5%) or stabilizers (n=99; 24.8%). One-fifth of children (n=86; 21.5%) experienced a BMI z-score reduction ≥0.25 units, a subgroup that was younger, had a higher BMI z-score at referral, and had a longer wait time between referral and baseline assessment (all P<0.05). Conclusions Most children who enrolled in paediatric weight management initiated treatment within six months and experienced a modest decrease or stabilization in BMI z-score during their wait time.