Miracle-dz/UniFAR-FTUs huggingface dataset:
Complementary medicine use, views, and experiences: a national survey in England

Background In 2005,12% of the English population visited a complementary and alternative medicine (CAM) practitioner. Aim To obtain up-to-date general population figures for practitioner-led CAM use in England, and to discover people's views and experiences regarding access. Design & setting A face-to-face questionnaire survey was commissioned. A nationally representative adult quota sample (aged ≥15 years) was used. Method Ten questions were included within Ipsos MORI’s weekly population-based survey. The questions explored 12-month practitioner-led CAM use, reasons for non-use, views on NHS-provided CAM, and willingness to pay. Results Of 4862 adults surveyed, 766 (16%) had seen a CAM practitioner. People most commonly visited CAM practitioners for manual therapies (massage, osteopathy, chiropractic) and acupuncture, as well as yoga, pilates, reflexology, and mindfulness or meditation. Women, people with higher socioeconomic status (SES) and those in south England were more likely to access CAM. Musculoskeletal conditions (mainly back pain) accounted for 68% of use, and mental health 12%. Most was through self-referral (70%) and self-financing. GPs (17%) or NHS professionals (4%) referred and/or recommended CAM to users. These CAM users were more often unemployed, with lower income and social grade, and receiving NHS-funded CAM. Responders were willing to pay varying amounts for CAM; 22% would not pay anything. Almost two in five responders felt NHS funding and GP referral and/or endorsement would increase their CAM use. Conclusion CAM use in England is common for musculoskeletal and mental health problems, but varies by sex, geography, and SES. It is mainly self-referred and self-financed; some is GP-endorsed and/or referred, especially for individuals of lower SES. Researchers, patients, and commissioners should collaborate to research the effectiveness and cost-effectiveness of CAM and consider its availability on the NHS.
Renalase as a Biomarker in Gestations with Preeclampsia

Gestation is featured by physiologic adaptations within systemic and renal hemodynamic systems. The initial hemodynamic adaptation in gestation is crucial systemic arterial vasodilatory physiological change [1]. On the other hand, hypertensive illnesses involve up to 10% of all gestations [2]. Preeclampsia the chief and most prominent hypertensive illness of gestation is the most common etiology and cause of various fetal and maternal clinical morbidity and mortality. Even though the clinical effect of the preeclampsia, management protocols of that disorder did not change significantly. This could be due to unclear pathophysiologic pathways of the disease. It is described by raised systemic arterial resistance levels. Failure of vascular refractoriness physiological feature to vasoconstricting agents contribute to the systemic occurrence of vascular vasoconstriction in preeclampsia [3]. A new hypothetical feature that has implied and investigated to elucidate the rise in blood pressure levels in gestations that have hyperadrenergic status may donate to the pathological pathway of preeclampsia. Prior research studies displayed that amplified sympathetic vasoconstricting effect is cornerstone pathological mechanism at vascular system level causing a raised vascular resistance [4-6]. Renalase is a variety of monoamine oxidase enzyme and it acts directly to degrade catecholamines (noradrenaline, adrenaline and dopamine). It reduces the blood pressure levels in vivo by inhibiting cardiac contractility feature and heart rate and blocking the compensatory mechanism rise in peripheral levels of vascular tone [7,8]. Consequently serum renalase is considered as a novel biological marker for primary hypertensive disease. It is secreted into the blood by the renal system. Up to date research studies have additionally displayed and revealed that renalase is secreted and synthesized within the peripheral nervous system, hypothalamus and the pituitary [9]. In an experimental research study, renalase expressive features is augmented in ovaries during gestation [10]. In the current research study the main goal to investigate the serum levels of renalase levels in clinically normal gestations and correlations between serum levels of renalase and blood pressure levels, glomerular filtration rate and protein excretion in urine in gestations with mild and severe preeclampsia [11]. Abstract
ECG Changes in Thyroid Dysfunction in Diabetes Mellitus

Introduction: Thyroid disorder and DM are the two most common endocrine disorders encountered in clinical practice which have been shown to mutually influence each other and relationship between both the conditions had long been reported. A certain ECG changes have been recognized in thyroid disorder. this study conducted to see the relation of Thyroid gland with diabetes mellitus in already diagnosed diabetic patients. Aim: To see the relation of Thyroid gland with diabetes mellitus in already diagnosed diabetic patients. Material and Methods: A cross sectional study conducted in Rohilkhand Medical College and Hospital, Bareilly to see the relation of Thyroid gland with diabetes mellitus in already diagnosed diabetic patients. Total 130 Diabetes mellitus patients, 7 patients (5.4%) had T1DM and 123 patients (94.6%) had T2DM selected purposively for the study [Table 2]. A patients were undergone to check the status of thyroid hormone, along with ECG. The data was collected and stastastically analyzed. Results: Mean age of the all patients were 49.20 ± 13.2 years. The most common clinical signs are a narrowed pulse pressure, diastolic hypertension, low cardiac output, reduced EF impaired diastolic function and bradycardia. [18] Overt hypothyroidism is associated with accelerated atherosclerosis and CAD due to hypercholesterolemia and diastolic hypertension. 34% of hypothyroidism showed significant ST-T ECG changes with angina and CAD on subsequent investigation. Reduced EF and diastolic dysfunction were also significant in this study. In hyperthyroidism, sinus tachycardia, AF, wide pulse pressure, dyspnoea on exertion, exercise intolerance are common. [17] Increased LV mass due to sustained volume overload with resultant cardiac work occurs in hyperthyroidism. [25] This may cause ST-T ECG changes due to LV strain. In this study, sinus tachycardia was the commonest ECG finding (61%), LV chamber hypertrophy was the second common abnormality (43%). ST-T ECG changes are due to LV strain occurs in 21% of cases of hyperthyroidism. Conclusions: Horizontal STsegment depression of 1mm or more 0.08 s from the Jpoint with Twave inversion was the ECG finding in 15 hypothyroidism; 3 in anterior LV wall leads, 4 in inferolateral LV wall leads. 10 hypothyroidism has sinus bradycardia in ECG , being the second commonest ECG abnormality. All hypothyroidism with STT changes had stable angina. The present study findings are in conformity with earlier studies. Sinus tachycardia was the commonest ECG finding in the hyperthyroidism 6(40%);LV hypertrophy 3 (20%); prolonged QTc interval 2(13.3%); LV strain(ST-T changes), Atrial fibrillation, Atrial ectopics and Ventricular ectopics 1(6.7%). www.jmscr. igmpublication.org Impact Factor (SJIF): 6.379 Index Copernicus Value: 79.54 ISSN (e)-2347-176x ISSN (p) 2455-0450 DOI: https://dx.doi. org/10.18535/jmscr/v7i1.14
Neurorehabilitation therapy of patients with severe stroke based on functional electrical stimulation commanded by a brain computer interface

Introduction Brain computer interface is an emerging technology to treat the sequelae of stroke. The purpose of this study was to explore the motor imagery related desynchronization of sensorimotor rhythms of stroke patients and to assess the efficacy of an upper limb neurorehabilitation therapy based on functional electrical stimulation controlled by a brain computer interface. Methods Eight severe chronic stroke patients were recruited. The study consisted of two stages: screening and therapy. During screening, the ability of patients to desynchronize the contralateral oscillatory sensorimotor rhythms by motor imagery of the most affected hand was assessed. In the second stage, a therapeutic intervention was performed. It involved 20 sessions where an electrical stimulator was activated when the patient's cerebral activity related to motor imagery was detected. The upper limb was assessed, before and after the intervention, by the Fugl–Meyer score (primary outcome). Spasticity, motor activity, range of movement and quality of life were also evaluated (secondary outcomes). Results Desynchronization was identified in all screened patients. Significant post-treatment improvement (p < 0.05) was detected in the primary outcome measure and in the majority of secondary outcome scores. Conclusions The results suggest that the proposed therapy could be beneficial in the neurorehabilitation of stroke individuals.
The executable pathway to biological

As time goes by, it becomes more and more apparent that the puzzles of life involve more and more molecular pieces that fit together in increasingly complex ways. Genomics and Proteomics technologies nowadays, produce reliable and quantitative data that could potentially reveal all the molecular pieces of a particular puzzle. However, this is akin to the opening of Pandora’s box; and we are now facing the problem of integrating this vast amount of data with its incredible complexity into some coherent whole. With the aid of engineering methods designed to build and analyze computerized man-made systems, a new emerging field called ‘Executable Biology’ aims to create computer programmes that put together the pieces in ways that allows capturing their dynamicity and ultimately elucidating how molecular function generates cellular function. This review aspires to highlight the main features characterizing these kinds of executable models and what makes them uniquely qualified to reason about and analyze biological networks.
Network Capital in a Multi-level World: Getting Support in Personal Communities

Multi-level analysis provides a new approach to studying the sources of network capital by integrating analyses of individuals, interpersonal ties and the personal networks in which they are embedded. Using this approach aids theory and substantive analysis. Toronto data show that while tie characteristics are key predictors of supportive behavior, networks facilitate the supportive behavior of ties and individuals. For example, parents and children are more supportive in networks with high percentages of parents and children. Individual agency, dyadic duets, and network properties all make network capital available for social support. Acknowledgments We are grateful to earlier collaborators in East York personal community research for the foundation laid for this study, to the Rockefeller Foundation for providing Wellman with a month’s stay to complete this work at the magnificent Bellagio (Italy) Center for Study and Conferences, and to the University of Toronto’s Centre for Urban and Community Studies for its thirty years of being an eminently supportive research base. The contributions of Milena Gulia, Catherine Kaukinen, Stephanie Potter and Scot Wortley have been especially important for our work here, as have been the comments of Dean Behrens, Bonnie Erickson, Vicente Espinoza, Nan Lin, Uwe Matzat, Pamela Popielarz, Ray Reagans, Fleur Thomese, Charles Tilly, Beverly Wellman, and the members of the “Socnet” electronic mail discussion list. Earlier versions of this paper were presented to the Duke University Social Networks and Social Capital Conference (1998), the American Sociological Association (1999, 2000) and the International Sunbelt Social Network Conference (1999, 2000). Our research has been supported by grants to Barry Wellman from the Bell Canada University Laboratories and the Social Science and Humanities Research Council of Canada. This chapter is dedicated to Natalie Sherban and Joan Harvey, founding stalwarts of East York’s Neighbourhood Information Centre, who have demonstrated or thirty years that an organization can provide social capital and foster supportive networks. 1Network capital is a form of “social capital”. Social capital is a sprawling term, ranging from an individualistic framework that emphasizes the advantages that individuals can gain through their personal networks to a collective perspective that emphasizes the advantages of volunteerism to a community (Coleman 1988; Paxton 1999; Putnam 2000; Lin 2001). For further discussions of social support, see Erickson, Radkewycz and Nosanchuk 1988; Gottlieb and Selby 1990; Kadushin 1981; Lin, Dean and Ensel 1986; Wellman 1999. Two other means of obtaining resources, less prevalent in industrialized countries, are self-provisioning (Pahl 1984) and coercive appropriation (such as robbery, theft, and extortion (Dickens 1839; Pileggi 1985; Turnbull 1972). 2We ignore here personal characteristics, such as intelligence, health and attractiveness. 1 Network Capital in a Multi-Level World
FAKTOR YANG BERHUBUNGAN DENGAN KEJADIAN DIARE PADA BALITA DI WILAYAH KERJA PUSKESMAS ABELI BAGIAN PESISIR KOTA KENDARI TAHUN 2017

Penyakit diare masih menjadi salah satu masalah kesehatan masyarakat yang penting karenamerupakan penyumbang utama angka kesakitan dan kematian pada anak diberbagai negaratermasuk Indonesia. Penelitian ini adalah untuk mengetahui faktor yang berhubungan dengankejadian diare pada Balita di wilayah kerja puskesmas Abeli bagian pesisir Kota Kendari tahun 2017.Metode penelitian yang digunakan adalah penelitian observasional analitik dengan pendekatan crosssectional study. Sampel dalam penelitian ini adalah 61 Balita yang berdomisili di wilayah pesisir yangtersebar di 3 (tiga) kelurahan yang masuk dalam wilayah kerja puskesmas Abeli, diantaranyakelurahan Lapulu, kelurahan Poasia, dan kelurahan Talia. Hasil uji statistik pada tingkat signifikasialpha 0,05 diperoleh hasil, (1) ada hubungan yang bermakna antara sarana penyediaan air bersihdengan kejadian diare Balita (ρValue= 0,000), (2) ada hubungan yang bermakna antara pembuangan airlimbah dengan kejadian diare Balita (ρValue= 0,000), (3) ada hubungan yang bermakna antara saranapembuangan sampah dengan kejadian diare Balita (ρValue= 0,022), (4) ada hubungan yang bermaknaantara pembuangan tinja dengan kejadian diare Balita (ρValue= 0,000), (5) ada hubungan yangbermakna antara kepadatan lalat dengan kejadian diare Balita (ρValue= 0,048). Diharapkan kepadamasyarakat untuk menjadikan penelitian ini sebagai informasi terkait penyebab meningkatnya Diareyang sering terjadi pada masyarakat sebagai upaya pencegahan awal terhadap penyakit Diare danbagi peneliti selanjutnya diharapkan untuk mengembangkan penelitian lebih lanjut.
Running head: Imatinib Cessation After Stable UMRD in CML

Most patients with chronic myeloid leukemia (CML) treated with imatinib will relapse if treatment is withdrawn. We conducted a prospective clinical trial of imatinib withdrawal in 40 chronic phase CML patients who had sustained undetectable minimal residual disease (UMRD) by conventional Q-PCR on imatinib for at least 2 years. Patients stopped imatinib and were monitored frequently for molecular relapse. At 24 months the actuarial estimate of stable treatment-free remission was 47.1%. Most relapses occurred within 4 months of stopping imatinib, and no relapses beyond 27 months were seen. In the 21 patients treated with interferon before imatinib a shorter duration of interferon treatment before imatinib was significantly associated with relapse risk, as was slower achievement of UMRD after switching to imatinib. Highly sensitive patient-specific BCR-ABL DNA PCR showed persistence of the original CML clone in all patients with stable UMRD, even several years after imatinib withdrawal. No patients with molecular relapse after discontinuation have progressed or developed BCR-ABL mutations (median follow-up 42 months). For personal use only. on April 13, 2017. by guest www.bloodjournal. org From
Tourism in the Serbian, Romanian and Hungarian borderline area as part of cross-border cooperation

In this paper, there have been presented potentials and possibilities for the development of tourism in borderline areas of Serbia, Romania and Hungary. Apart from the existing differences, there are similarities in the geographic space, similar historic events, religious and other demographic characteristics, attractive tourist sites in the borderline areas of Serbia Romania and Hungary, representing compatible tourist cross-border regions. Dominant tourist activities in the observed area are: transit tourism on the rivers of Danube and Tisza, spa, cultural, event, religious, sports and recreational and rural tourism. Tradition, folklore and lifestyle are based on the multiethnic characteristics' of the area and other economic conditions represented in these tourist regions. The establishment of cross-border regions emphasizes the possibilities for the stronger cultural, economic sports, scientific, technological and other forms of cooperation among Serbia, Romania and Hungary, as well as among other countries in the region. The Euro region Danube- Tisza-Kris-Mures on the cross-border area of Serbia Hungary and Romania, the Đerdap Gorge on the Serbian and Romanian cross border area as cross-border eco-park and tourist region, have a potential to develop as an important international tourist destination on the global tourist market.
Femoral Ceramic-Tibial Ceramic Total Knee Arthroplasty (Yokohama Medical Ceramic Knee)-Surgical Techniques and Long-Term Clinical Results for Severe Rheumatoid Arthritis

The bioceramic total knee prosthesis of Yokohama medical ceramic knee (YMCK) type is unique, being composed of an alumina ceramic femoral component, an ultra high-molecular weight polyethylene (UHMWPE)-bearing plate firmly fixed on the alumina ceramic tibial tray and a UHMWPE patellar dome with a large central peg. These prostheses have been developed to obtain an extremely low-friction total knee joint. The clinical results of YMCK total knee arthroplasty were reviewed. Initially, the prostheses were inserted using a cementless technique that was later changed to a cemented technique to avoid aseptic loosening. In the same way, the shape of the patellar dome was changed from a tripod to a large central peg for bone surface fixation. The clinical results of cementless and cemented arthroplasty were reported previously. More than 10 years' long-term follow-up of cemented YMCK knees showed satisfactory results. Evaluation of wear of the UHMWPE surface was performed on 3 retrieved cementless knees, and a wear test using simulation is described. The advantages and disadvantages of ceramic total knee arthroplasty are discussed.
The Catastrophic Flash-Flood Event of 8–9 September 2002 in the Gard Region, France: A First Case Study for the Cévennes–Vivarais Mediterranean Hydrometeorological Observatory

The Cevennes–Vivarais Mediterranean Hydrometeorological Observatory (OHM-CV) is a research initiative aimed at improving the understanding and modeling of the Mediterranean intense rain events that frequently result in devastating flash floods in southern France. A primary objective is to bring together the skills of meteorologists and hydrologists, modelers and instrumentalists, researchers and practitioners, to cope with these rather unpredictable events. In line with previously published flash-flood monographs, the present paper aims at documenting the 8–9 September 2002 catastrophic event, which resulted in 24 casualties and an economic damage evaluated at 1.2 billion euros (i.e., about 1 billion U.S. dollars) in the Gard region, France. A description of the synoptic meteorological situation is first given and shows that no particular precursor indicated the imminence of such an extreme event. Then, radar and rain gauge analyses are used to assess the magnitude of the rain event, which was particularly remarkable for its spatial extent with rain amounts greater than 200 mm in 24 h over 5500 km2. The maximum values of 600–700 mm observed locally are among the highest daily records in the region. The preliminary results of the postevent hydrological investigation show that the hydrologic response of the upstream watersheds of the Gard and Vidourle Rivers is consistent with the marked space–time structure of the rain event. It is noteworthy that peak specific discharges were very high over most of the affected areas (5–10 m3 s−1 km−2) and reached locally extraordinary values of more than 20 m3 s−1 km−2. A preliminary analysis indicates contrasting hydrological behaviors that seem to be related to geomorphological factors, notably the influence of karst in part of the region. An overview of the ongoing meteorological and hydrological research projects devoted to this case study within the OHM-CV is finally presented.
Beware of anal fissures: pemphigus vulgaris of the anal canal

A case of anal pemphigus vulgaris in a 49-year-old female suffering from pemphigus vulgaris of the oral cavity is reported. The oral manifestations were in remission until she presented with episodes of anal pain and bleeding on defecation, initially mimicking anal fissures. Inspection revealed prominent painful erosions in the anal canal with external hemorrhoids and strands of sloughing skin and maceration in the anal verge. Histology and direct immunofluorescence test were consistent with pemphigus vulgaris. The disease was refractory to treatment and complete remission was only achieved with the combination of rituximab and corticosteroids. Anal involvement seems to be an uncommon or underreported manifestation of pemphigus vulgaris. Gastroenterologists should be aware of this entity, especially in areas with a high incidence of the disease, for appropriate diagnosis and management.
Where users’ find the answer: discovery layers versus databases

Abstract Usage statistics for 2015–2017 of searches and electronic resource access actions in Ex Libris Primo, a discovery layer, are compared with COUNTER databases searches, result clicks, and record views, and journal full-text article requests. Results show a decrease in COUNTER result clicks and record views in databases and journal full-text article requests and a slight increase in Primo access actions. Concurrently, searches performed in databases and Primo increase slightly which increases the ratio of searches performed to access actions taken, inferring that users may be having more difficulty locating relevant resources, or relevant resources are not available.