Miracle-dz/UniFAR-FTUs huggingface dataset:
Electrical Stimulation of Alpha Oscillations Stabilizes Performance on Visual Attention Tasks

Neural oscillations in the alpha band (7–13 Hz) have long been associated with reductions in attention. However, recent studies have suggested a more nuanced perspective in which alpha oscillations also facilitate processes of cognitive control and perceptual stability. Transcranial alternating current stimulation (tACS) over occipitoparietal cortex at 10 Hz (alpha-tACS) can selectively enhance EEG alpha power. To assess the contribution of alpha oscillations to attention, we delivered alpha-tACS across 4 experiments while 178 participants performed sustained attention tasks. Poor performance on all visual tasks was previously associated with increased EEG alpha power. We therefore predicted initially that alpha-tACS would consistently impair visual task performance. However, alpha-tACS was instead found to prevent deteriorations in visual performance that otherwise occurred during sham- and 50 Hz-tACS. This finding was observed in 2 experiments, using different sustained attention tasks. In a separate experiment, we also found that alpha-tACS limited improvements on a visual task where learning was otherwise observed. Consequently, alpha-tACS appeared to exert a consistently stabilizing effect on visual attention. Such effects were not seen in an auditory control task, indicating specificity to the visual domain. We suggest that these results are most consistent with the view that alpha oscillations facilitate processes of top-down control and attentional stability.
Profile of caregivers of Parkinson’s disease patients and burden measured by Zarit Scale Analysis of potential burden-generating factors and their correlation with disease severity

Abstract Parkinson’s disease (PD) promotes burden among patients and caregivers. Objective: To analyze whether disease severity (UPDRS and Karnofsky index), total disease duration, patient cognitive status (MMSE), presence of other diseases, patient age, socioeconomic conditions (ABEP2015), living together with patient, total time caregiving, weekly hours of care and presence of assistance from other caregivers are correlated with, and influence statistically, the degree of caregiver burden measured by the Zarit Burden Interview (ZBI). Methods: After ethics Committee approval, patients and respective caregivers were recruited. Following evaluation with the proper scales, all data were submitted to Pearson’s correlation method and multivariate linear regression analysis (ANOVA). Results: A total of 21 patients and respective caregivers were evaluated. 72% (N=15) of caregivers reported burden. One third of caregivers reported a moderate or severe level of burden. A cause-effect relationship could not be established by the statistical method adopted, but disease severity measured by the UPDRS was the sole variable showing statistically significant moderate positive Pearson’s correlation with ZBI (r=0.48, for p<0.05). On ANOVA, however, no independent variable had a statistically significant impact on ZBI scores. Conclusion: Despite our conflicting results, optimization of the available treatment, with better control of PD severity, can be considered an important element to effectively achieve the goal of reducing burden among caregivers.
Clustering time series based on dependence structure

The clustering of time series has attracted growing research interest in recent years. The most popular clustering methods assume that the time series are only linearly dependent but this assumption usually fails in practice. To overcome this limitation, in this paper, we study clustering methods applicable to time series with a general and dependent structure. We propose a copula-based distance to measure dissimilarity among time series and consider an estimator for it, where the strong consistency of the estimator is guaranteed. Once the pairwise distance matrix for time series has been obtained, we apply a hierarchical clustering algorithm to cluster the time series and ensure its consistency. Numerical studies, including a large number of simulations and analysis of practical data, show that our method performs well.
Femoral Tunnel Drilling Method: Risk of Reoperation and Revision After Anterior Cruciate Ligament Reconstruction

Background: The femoral tunnel in anterior cruciate ligament reconstruction (ACLR) can be created by the transtibial (TT) or tibial-independent (TI) methods. An anatomically located femoral tunnel can be more consistently achieved by TI methods, which include the anteromedial portal and lateral (outside-in, retrodrill) techniques. Nonanatomic graft placement in ACLR can result in postoperative instability and meniscal or chondral injury. An anatomically located graft is subjected to higher postoperative physiologic forces than one placed nonanatomically. Purpose: To examine isolated primary ACLR and determine the risk of aseptic revision and reoperation based on femoral tunnel drilling method. Study Design: Cohort study; Level of evidence, 2. Methods: The ACLR registry of an integrated US health care system was used to identify primary isolated unilateral ACLRs from 2009 to 2014. Multivariable Cox proportional hazard regression models were used to evaluate risk for aseptic revision for graft failure and aseptic reoperation for meniscal or chondral injury according to femoral tunnel drilling method: TI versus TT. Models included age, sex, body mass index (BMI), race, graft type, and femoral fixation type as covariates. Results: The cohort included 19,059 patients with primary ACLR. The mean age was 28.9 years (SD, 11.5), 6991 patients (36.8%) were younger than 22 years, 11,795 patients (61.9%) were male, 7648 patients (40.1%) had a BMI less than 25 kg/m2, 8913 patients (46.8%) were white, and 7357 patients (38.6%) received an allograft. Median follow-up was 2.30 years (interquartile range, 1.08-3.77). TI techniques were used for 12,342 (64.8%) of the ACLRs, and the TT method was used for 6717 (35.2%). Use of TI techniques increased from 33.6% of all ACLRs in 2009 to 83.4% in 2014. After adjustment for covariates, the TI group had a higher risk for aseptic revision than the TT group (hazard ratio [HR], 1.28; 95% CI, 1.04-1.56), and this risk was 1.41 times higher in patients younger than 22 years specifically. The 5-year cumulative reoperation probability was lower in the TI group (4.50%; 95% CI, 3.78%-5.36%) compared with the TT group (5.06%; 95% CI, 4.31-5.94%). After adjustment for the covariates, no difference in risk for aseptic reoperation was observed (HR, 1.08; 95% CI, 0.85-1.39). Conclusion: In the largest known study of its type examining femoral tunnel drilling method for primary ACLR, after adjustment for age, sex, BMI, race, graft type, and femoral fixation, TI techniques were found to carry higher risk of aseptic revision compared with the TT method, while no difference was observed in risk for aseptic reoperation.
Iteratively Training Look-Up Tables for Network Quantization

Operating deep neural networks (DNNs) on devices with limited resources requires the reduction of their memory as well as computational footprint. Popular reduction methods are network quantization or pruning, which either reduce the word length of the network parameters or remove weights from the network if they are not needed. In this article, we discuss a general framework for network reduction which we call Look-Up Table Quantization (LUT-Q). For each layer, we learn a value dictionary and an assignment matrix to represent the network weights. We propose a special solver which combines gradient descent and a one-step k-means update to learn both the value dictionaries and assignment matrices iteratively. This method is very flexible: by constraining the value dictionary, many different reduction problems such as non-uniform network quantization, training of multiplierless networks, network pruning, or simultaneous quantization and pruning can be implemented without changing the solver. This flexibility of the LUT-Q method allows us to use the same method to train networks for different hardware capabilities.
A platform for systematic verification of embedded components in IP-XACT, SystemC and Promela

Nowadays systematic verification is essential because embedded systems are involved in processes decisions that affect the life of humans and they are subject to several constraints in interaction with dangerous processes. To ensure the proper functioning of these systems and reduce the degree of failure of an internal part and the time to market, we opt for formal method of verification which deals particularly with "Model-Checking" model verification by implementing our new verification platform SysVerPml that uses protocol models written in Promela language (PROcess Meta LAnguage) and integrating generic properties in LTL (Linear Temporal Logic) that can be simulated and verified by the Spin software and its Ispin GUI to detect all the possibilities of error. Until now, there have been few research papers directed towards converting SystemC models to Promela language, and until today there is no free platform that is dedicated to this verification process.
Lifelong Learning of Action Representations with Deep Neural Self-Organization

Lifelong learning is fundamental in autonomous robotics for the incremental acquisition of knowledge through experience. However, most of the current deep neural models for action recognition from videos do not account for lifelong learning, but rather learn a batch of training actions. Consequently, there is the need to design learning systems with the ability to incrementally process available perceptual cues and to adapt their behavioral responses over time. We propose a self-organizing neural network architecture for incrementally learning action sequences from videos. The architecture comprises growing self-organizing networks equipped with recurrent connectivity for dealing with time-varying patterns. We use a set of hierarchically-arranged recurrent networks for the unsupervised learning of action representations with increasingly large spatiotemporal receptive fields. The recurrent dynamics modulating neural growth drive the adaptation of the networks to the non-stationary input distribution during the learning phase. We show how our model accounts for an action classification task with a benchmark dataset also in the case of occasionally missing or incorrect sample labels.
Depression, anxiety, and stress and their association with khat use: a cross-sectional study among Jazan University students, Saudi Arabia

Background Depression, anxiety, and stress levels are considered important indicators for mental health. Khat chewing habit is prevalent among all segments of Jazan population in Saudi Arabia. Few studies have been conducted to evaluate depression, anxiety, and stress among Jazan University students, and information about the correlation between khat use and these disorders is scarce. Thus, this study aims to evaluate the prevalence of depression, anxiety, and stress and their correlation with khat chewing and other risk factors among Jazan University students. Methods A cross-sectional study was conducted on 642 students from Jazan University. Multistage sampling was used, with probability proportional to size-sampling technique. The Depression, Anxiety, and Stress Scale 21 questionnaire was used to collect the data, which were analyzed using SPSS Version 20.0 software. Results Moderate depression was prevalent among 53.6% of the sample, anxiety was found among 65.7%, while 34.3% of the students suffered from stress. Female gender was strongly associated with higher mean scores for symptoms of depression, anxiety, and stress, with P-values <0.05 for all. Moreover, anxiety symptoms scores were statistically associated with grade point average and caffeine consumption. Khat use was statistically associated with higher mean scores of anxiety among males and a higher mean score of depression and anxiety among females. Conclusion The results indicate a high rate of symptoms of depression, anxiety, and stress among Jazan University students. Khat use was associated with anxiety, and a higher rate of symptoms of depression, anxiety, and stress was indicated among female students. Therefore, strategy for the prevention and management of depression, anxiety, and stress is highly recommended to minimize the impact of these serious disorders.
Active Interpretation of Visual Situations

We describe an architecture for active interpretation of visual situations. A visual situation is an abstract concept— e.g., “a boxing match”, “a birthday party”, “walking the dog”, “waiting for a bus”—whose image instantiations are linked more by their common spatial and semantic structure than by low-level visual similarity. Our system combines given and learned knowledge of the structure of a particular situation, and adapts that knowledge to a new situation instance as it actively searches for visual elements relevant to the situation. As a preliminary step, we test our approach’s ability to use situation knowledge to efﬁciently localize relevant objects, using a situation-speciﬁc image dataset created by our group. We compare the results with several baselines and variations on our method, and demonstrate the strong beneﬁt of using situation knowledge and active context-driven localization.
Notch1 serves as a prognostic factor and regulates metastasis via regulating EGFR expression in hypopharyngeal squamous cell carcinoma

Objective Hypopharyngeal squamous cell carcinoma (HSCC) remains one of the most lethal malignancies in head and neck. Notch1 has been validated to play prominent roles in the occurrence and development of various types of cancer. The aim of this study was to explore the function and underlying mechanism of Notch1 in HSCC. Patients and methods Seventy-one cancer tissue samples and adjacent noncancerous formalin-fixed paraffin embedded tissue specimens were analyzed by immunohistochemistry. As Notch1 is overexpressed in HSCC, we further questioned whether there was a relationship between Notch1 and the clinicopathological characteristics. After confirming the successful knockdown of Notch1 by siRNA, the migration and invasion after gene knockdown were investigated by Transwell chambers. We then tried to identify YBX1 and EGFR expression using real-time PCR (RT-PCR) and Western blot analyses. To further determine whether the downexpression of EGFR was caused by YBX1 and the overexpression of YBX1 was caused by gene amplification, the expression of EGFR was detected by RT-PCR and Western blot assays. Results We found that the expression of Notch1 and EGFR in HSCC tissues was upregulated compared with those in the adjacent noncancerous tissues. Further clinicopathological characteristics analysis revealed that the expression of Notch1 was positively correlated with distant metastasis (P=0.003) and tumor differentiation (P=0.031). The high expression of Notch1 is an independent prognostic factor for a poor overall survival in patients with HSCC (P=0.015, χ2=10.403). Knocking down of Notch1 significantly inhibits the migration and invasion of FaDu cells in vitro. Mechanistic investigation reveals that Notch1 knockdown is found suppressing the expression of EGFR at transcriptional level. Interestingly, we further found that Notch1 knockdown also decreased the expression of YBX1, which is a transcription factor of EGFR. Moreover, the upregulation of YBX1 reverses the suppression of Notch1 on EGFR. Furthermore, forced overexpression of YBX1 induced the invasion of FaDu cells. Conclusion Taken together, we found a positively cross-linked role of Notch1 signaling in the outcome of HSCC, providing a novel valuable prognostic marker and potential therapeutic target for the treatment of HSCC patients. Notch1 is a core signaling molecule for regulating migration and invasion via interplaying with EGFR in HSCC cells.
Influence of hepatic steatosis on the outcomes of patients with chronic hepatitis B treated with entecavir and tenofovir

Background/Aims The influence of hepatic steatosis (HS) on chronic hepatitis B (CHB) is unclear. We evaluated the influence of the degree of HS, assessed using the controlled attenuation parameter (CAP) of transient elastography (TE), on treatment outcomes in CHB patients initiated on antiviral therapy. Methods A total of 334 patients who were initiated on entecavir or tenofovir between 2007 and 2016 with available TE results were recruited. Results Of the total study population, 146 (43.7%) patients had HS (CAP > 238 dB/m). Three-hundred-three patients (90.7%) achieved complete virological response (CVR) (hepatitis B virus DNA<12 IU/L), and 25 patients (7.5%) developed hepatocellular carcinoma (HCC). Among hepatitis B e antigen (HBeAg)-positive patients (n=172, 51.5%), 37 (21.5%) experienced HBeAg loss. On univariate analysis, CAP value was not associated with the probability of HCC development (P=0.380). However, lower CAP value was independently associated with higher probability of HBeAg loss among HBeAg-positive patients (hazard ratio [HR]=0.991, P=0.026) and with CVR achievement in the entire study population (HR=0.996, P=0.004). The cumulative incidence of HBeAg loss among HBeAg-positive patients was significantly higher in patients without HS than in those with HS (log-rank, P=0.022). Conclusions CAP values were not correlated with HCC development in patients initiated on entecavir and tenofovir. However, CAP values were negatively correlated with the probability of HBeAg loss among HBeAg-positive patients and with CVR achievement.
Melatonin in the seasonal response of the aphid Acyrthosiphon pisum

Aphids display life cycles largely determined by the photoperiod. During the warm long‐day seasons, most aphid species reproduce by viviparous parthenogenesis. The shortening of the photoperiod in autumn induces a switch to sexual reproduction. Males and sexual females mate to produce overwintering resistant eggs. In addition to this full life cycle (holocycle), there are anholocyclic lineages that do not respond to changes in photoperiod and reproduce continuously by parthenogenesis. The molecular or hormonal events that trigger the seasonal response (i.e., induction of the sexual phenotypes) are still unknown. Although circadian synthesis of melatonin is known to play a key role in vertebrate photoperiodism, the involvement of the circadian clock and/or of the hormone melatonin in insect seasonal responses is not so well established. Here we show that melatonin levels in the aphid Acyrthosiphon pisum are significantly higher in holocyclic aphids reared under short days than under long days, while no differences were found between anholocyclic aphids under the same conditions. We also found that melatonin is localized in the aphid suboesophageal ganglion (SOG) and in the thoracic ganglionic mass (TGM). In analogy to vertebrates, insect‐type arylalkylamine N‐acetyltransferases (i‐AANATs) are thought to play a key role in melatonin synthesis. We measured the expression of four i‐AANAT genes identified in A. pisum and localized two of them in situ in the insect central nervous systems (CNS). Levels of expression of these genes were compatible with the quantities of melatonin observed. Moreover, like melatonin, expression of these genes was found in the SOG and the TGM.
Development of the Self-Forgiveness Dual-Process Scale

Progress in the scientific study of self-forgiveness reveals a need for (a) integration of the extant self-forgiveness literature with general psychological theory, (b) development of measures that reflect nuanced conceptualizations of self-forgiveness, (c) better understanding of the impact of self-forgiveness on personal and interpersonal functioning, and (d) development of evidence-based clinical applications of self-forgiveness. Accordingly, we conceptualized self-forgiveness within the framework of Social Cognitive Theory and developed the Self-Forgiveness Dual-Process Scale to assess value reorientation (VRO) and esteem restoration (ERS) following perceived interpersonal offense. In Study 1, we identified the hypothesized 2-factor structure in a sample of university students (N = 191). For Study 2, we used an independent sample (N = 100) to replicate the factor structure and provide initial evidence of construct validity by exploring associations of value reorientation and esteem restoration with established measures of self-forgiveness, self-punishment, and self-exoneration. In Study 3, we recruited a third sample (N = 66) to assess contributions of value reorientation and esteem restoration to explain variance in offense-related rumination beyond that explained by an existing measure of state self-forgiveness. Overall, findings supported conceptualization of self-forgiveness according to processes of value reorientation and esteem restoration, distinguished self-forgiveness from other responses to wrongdoing, and revealed the unique impacts of value reorientation and esteem restoration on functioning.
Tramadol: a valuable treatment for pain in Southeast Asian countries

Background The supply of controlled drugs is limited in the Far East, despite the prevalence of health disorders that warrant their prescription. Reasons for this include strict regulatory frameworks, limited financial resources, lack of appropriate training amongst the medical profession and fear of addiction in both general practitioners and the wider population. Consequently, the weak opioid tramadol has become the analgesic most frequently used in the region to treat moderate to severe pain. Methods To obtain a clearer picture of the current role and clinical use of tramadol in Southeast Asia, pain specialists from 7 countries in the region were invited to participate in a survey, using a questionnaire to gather information about their individual use and experience of this analgesic. Results Fifteen completed questionnaires were returned and the responses analyzed. Tramadol is used to manage acute and chronic pain caused by a wide range of conditions. Almost all the specialists treat moderate cancer pain with tramadol, and every one considers it to be significant or highly significant in the treatment of moderate to severe non-cancer pain. The reasons for choosing tramadol include efficacy, safety and tolerability, ready availability, reasonable cost, multiple formulations and patient compliance. Its safety profile makes tramadol particularly appropriate for use in elderly patients, outpatients, and for long-term treatment. The respondents strongly agreed that tighter regulation of tramadol would reduce its medical availability and adversely affect the quality of pain management. In some countries, there would no longer be any appropriate medication for cancer pain or the long-term treatment of chronic pain. Conclusions In Southeast Asia, tramadol plays an important part in the pharmacological management of moderate to severe pain, and may be the only available treatment option. If it were to become a controlled substance, the standard of pain management in the region would decline.
Phthirus pubis Infestation of the Scalp: A Case Report and Review of The Literature

Phthirus pubis usually infests the pubis, groin, buttocks and perianal region. It can sometimes infest the thighs, abdomen, chest, axillae and beard. Eyelashes and eyebrows may be involved in children. The involvement of the scalp is very rare. We describe a case of P. pubis infestation located exclusively on the scalp in an adult woman. Neither lice/nits nor skin lesions were observed elsewhere, including eyebrows, eyelashes, axillae, pubis, buttocks and perianal region (the patient was hairless in the axillae and pubis). A review of the literature is enclosed.