Miracle-dz/UniFAR-FTUs huggingface dataset:
Study of Hyperkyphosis, Exercise and Function (SHEAF) Protocol of a Randomized Controlled Trial of Multimodal Spine-Strengthening Exercise in Older Adults With Hyperkyphosis

Background Hyperkyphosis negatively affects health status, physical mobility, and quality of life, but there is no standard protocol for treating people with hyperkyphosis. Treatment options include targeted exercise. Objectives This single-site randomized controlled trial (RCT) will determine the efficacy of a targeted multimodal spine-strengthening exercise program, compared with no exercise intervention, among community-dwelling men and women aged ≥60 years. Design The RCT is a parallel-group design, with 1:1 randomization to exercise and attentional control groups. Setting The study will be conducted at one primary site (one academic medical center partnered with one local community medical center). Participants One hundred men and women, aged ≥60 years, with thoracic kyphosis ≥40 degrees will be randomized. Intervention The targeted multimodal spine-strengthening exercise intervention includes exercise and postural training delivered by a physical therapist in a group of 10 participants, 3 times a week for 6 months. Controls receive monthly health education meetings in a group of 10 participants and monthly calls from the study coordinator to monitor physical activity and any adverse events. Measurements The primary outcome is change in Cobb angle of kyphosis measured from lateral spine radiographs at baseline and 6 months. Secondary outcomes include change in physical function (assessed with the modified Physical Performance Test, Timed “Up & Go” Test, timed loaded standing, 4-m walk, and Six-Minute Walk Test) and health-related quality of life (assessed with the modified Scoliosis Research Society instrument [SRS-30] self-image domain and Patient Reported Outcomes Measurement Information System [PROMIS] global health and physical function indexes). Additional secondary outcomes include pain, physical activity level, spinal flexion and extension muscle strength, paraspinal extensor muscle density, and adverse events. Limitations Blinding of the participants and instructors providing the intervention is not possible. Conclusions The efficacy of a high-quality, adequately powered exercise intervention in men and women with kyphosis ≥40 degrees will be evaluated to determine whether targeted multimodal spine-strengthening exercise reduces hyperkyphosis in older adults and improves important secondary outcomes of physical function and health-related quality of life.
The importance of the meniscus in unstable knees

This study analyzes differences in knee function in ACL deficient knees with different meniscus status. Eighty patients, 12 women and 68 men, were matched in four groups according to sex, age, knee injuries, and follow up time. Group I had two intact menisci; Group II, one meniscus successfully repaired; Group III, one menis cus removed; and Group IV, both menisci removed. The ACL was repaired acutely or reconstructed later in most cases and other significant ligament injuries were treated. All patients were reexamined clinically 6 to 8 years after injury. Knee function was recorded using the Lysholm knee function score. Activity level before injury and at followup was rated with the Tegner scale. Stability was tested and weightbearing roentgen ograms were taken. There was a higher frequency of ACL reconstructions in Groups I and II, but instability was the same in all groups. No difference was found in Lysholm score (range, 86 to 92). The activity level was higher in Group IV at followup. A lower frequency of motion impairment was found in Group III, (20% versus 50%). Subjective evaluation was similar and positive in all groups. Group I had six meniscus ruptures during the follow-up period. In Group II three of the repaired menisci were removed, as were two of the contralateral menisci in Group III. Roentgenograms, available in 55 of 80 cases, showed osteoarthritis in 65%. There were no differences in the frequency of osteoarthritis among the first three groups, but Group IV had a higher incidence of osteoar thritic changes. Osteoarthritis did not result in lower knee function, poorer subjective evaluation, or in creased impairment of motion. Of the patients with osteoarthritis, more maintained their preinjury activities. In terms of function and osteoarthritis, instability and chosen activity level seemed to be of prognostic impor tance.
A novel computer-aided lung nodule detection system for CT images.

PURPOSE The paper presents a complete computer-aided detection (CAD) system for the detection of lung nodules in computed tomography images. A new mixed feature selection and classification methodology is applied for the first time on a difficult medical image analysis problem. METHODS The CAD system was trained and tested on images from the publicly available Lung Image Database Consortium (LIDC) on the National Cancer Institute website. The detection stage of the system consists of a nodule segmentation method based on nodule and vessel enhancement filters and a computed divergence feature to locate the centers of the nodule clusters. In the subsequent classification stage, invariant features, defined on a gauge coordinates system, are used to differentiate between real nodules and some forms of blood vessels that are easily generating false positive detections. The performance of the novel feature-selective classifier based on genetic algorithms and artificial neural networks (ANNs) is compared with that of two other established classifiers, namely, support vector machines (SVMs) and fixed-topology neural networks. A set of 235 randomly selected cases from the LIDC database was used to train the CAD system. The system has been tested on 125 independent cases from the LIDC database. RESULTS The overall performance of the fixed-topology ANN classifier slightly exceeds that of the other classifiers, provided the number of internal ANN nodes is chosen well. Making educated guesses about the number of internal ANN nodes is not needed in the new feature-selective classifier, and therefore this classifier remains interesting due to its flexibility and adaptability to the complexity of the classification problem to be solved. Our fixed-topology ANN classifier with 11 hidden nodes reaches a detection sensitivity of 87.5% with an average of four false positives per scan, for nodules with diameter greater than or equal to 3 mm. Analysis of the false positive items reveals that a considerable proportion (18%) of them are smaller nodules, less than 3 mm in diameter. CONCLUSIONS A complete CAD system incorporating novel features is presented, and its performance with three separate classifiers is compared and analyzed. The overall performance of our CAD system equipped with any of the three classifiers is well with respect to other methods described in literature.
Histone deacetylase inhibitor chidamide promotes reactivation of latent human immunodeficiency virus by introducing histone acetylation

Highly active antiretroviral therapy can reduce the human immunodeficiency virus (HIV) viral load in the plasma to undetectable levels. However, because of the presence of latent HIV reservoirs, it is difficult to completely eradicate HIV in infected patients. Our objective was to assess the potency of chidamide, a novel histone deacetylase inhibitor recently approved for cancer treatment by the China Food and Drug Administration, to reactivate latent HIV‐1 via histone acetylation. Viral reactivities of chidamide were accessed in 2 latent HIV pseudotype virus cell reporter systems (J‐Lat Tat‐green fluorescent protein clone A72 and TZM‐bl), a latently infected full‐length HIV virus cell system (U1/HIV), and resting CD4+ T cells from 9 HIV‐infected patients under highly active antiretroviral therapy with undetectable viral load. Chidamide was able to increase HIV expression in each cell line, as evidenced by green fluorescent protein, luciferase activity, and p24, as well as to reactivate latent HIV‐1 in primary CD4+ T cells of HIV‐infected patients. Histone acetylation adjacent to the HIV promoter in A72 cells was determined by chromatin immunoprecipitation. Chidamide was able to increase histone H3 and H4 acetylation at the HIV promoter. In brief, chidamide induced the reactivation of latent HIV in pseudotype virus reporter cells, latently infected cells, and primary CD4+ T cells, making this compound an attractive option for future clinical trials.
Happiness and Financial Satisfaction in Israel: Effects of Religiosity, Ethnicity, and War

We analyze individual satisfaction with life as a whole and satisfaction with the personal financial situation for Israeli citizens of Jewish and Arab descent. Our data set is the Israeli Social Survey (2006). We are especially interested in the impact of the religions Judaism, Islam and Christianity, where we are able to differentiate between individuals who vary in religiosity between secular and ultra-orthodox. We find a significant effect of religiosity on happiness. With respect to Jewish families it is most striking that the impact of family size on both life and financial satisfaction seems to vary with religiosity. This might be a reason for differentiation in family equivalence scales. For Arab families we did not find this effect. First-generation immigrants are less happy than second-generation immigrants, while there is no significant difference between second-generation families and native families. The effect of the Lebanon war is much less than expected.
Comparison of two rapid culture methods for detection of cytomegalovirus in clinical specimens

The conventional virus isolation technique was compared with a 24-h shell vial centrifugation culture technique and with a 48-h tube culture method for the detection of cytomegalovirus (CMV) in MRC-5 cells. Of 200 clinical specimens tested, 41 were positive for CMV by at least one procedure. Indirect immunoperoxidase staining was positive for 32 (78.0%) of 41 specimens in the tube culture method and for 30 (73.2%) of 41 specimens in the shell vial centrifugation method. CMV was detected in 23 (56.1%) of 41 specimens by the development of cytopathic effect within 14 days.
Increased evapotranspiration demand in a Mediterranean climate might cause a decline in fungal yields under global warming

Wild fungi play a critical role in forest ecosystems, and its recollection is a relevant economic activity. Understanding fungal response to climate is necessary in order to predict future fungal production in Mediterranean forests under climate change scenarios. We used a 15‐year data set to model the relationship between climate and epigeous fungal abundance and productivity, for mycorrhizal and saprotrophic guilds in a Mediterranean pine forest. The obtained models were used to predict fungal productivity for the 2021–2080 period by means of regional climate change models. Simple models based on early spring temperature and summer–autumn rainfall could provide accurate estimates for fungal abundance and productivity. Models including rainfall and climatic water balance showed similar results and explanatory power for the analyzed 15‐year period. However, their predictions for the 2021–2080 period diverged. Rainfall‐based models predicted a maintenance of fungal yield, whereas water balance‐based models predicted a steady decrease of fungal productivity under a global warming scenario. Under Mediterranean conditions fungi responded to weather conditions in two distinct periods: early spring and late summer–autumn, suggesting a bimodal pattern of growth. Saprotrophic and mycorrhizal fungi showed differences in the climatic control. Increased atmospheric evaporative demand due to global warming might lead to a drop in fungal yields during the 21st century.
Measurement analysis of polarization distribution of static on-body propagation channels

On-body propagation channels show significant polarization selectivity in static and dynamic scenarios. In this work, we measured polarized on-body channels on static body at 2.4 GHz by monopole antennas, where standing and sitting postures are considered. The polarization direction of the antenna (Z-polarization, H-polarization, V-polarization) depends on the direction of the antenna in the body position. In the statistical characteristics of the channels, the V-polarization direction of the receiving antenna is more conducive for receiving signal and reducing the path losses. Cross-polar discrimination (XPD) is calculated, showing that strong depolarization of on-body channels are more easily caused in sitting posture due to scattering effects from the legs. In all the polarization combinations measured, the receiving antenna generally maintain a dominant field component along the V-polarization direction.
Replicative RNA synthesis and nucleocapsid assembly in vesicular stomatitis virus-infected permeable cells

A permeable-cell system has been developed to study the replication of vesicular stomatitis virus. When vesicular stomatitis virus-infected BHK cells were permeabilized by lysolecithin treatment, they incorporated nucleoside triphosphates into RNA and amino acids into proteins at nearly normal rates. The viral mRNA's synthesized appeared normal in polarity, size distribution, and polyadenylation, and all five viral proteins were synthesized. Replication of the viral genome proceeded, and full-length RNA strands were synthesized in amounts and polarities resembling those found in intact cells. These full-length RNAs associated with viral N proteins to form RNase-resistant nucleocapsids of normal buoyant density. Permeable cells appear to represent ideal hosts for studying vesicular stomatitis virus replication since they closely mimic in vivo conditions while retaining much of the experimental flexibility of current in vitro systems.
A system for predicting and preventing work-related musculoskeletal disorders among dentists

Work-related musculoskeletal disorders (WMSDs) have become increasingly common among dentists and initiate a series of events that could result in a career ending. This study aims to construct a system for predicting and preventing WMSD among dentists. We used Bayesian network (BN) that describes the mutual relationships among multiple variables contributing to WMSDs. The data-sets were prepared from direct measurements of dentist's movements and a questionnaire survey. We applied BN learning algorithms to the training data-sets to develop WMSD prediction model using 10-fold cross-validation. To evaluate the system performance, 16 dentists were randomly assigned into a 2 × 2 crossover trial scheduled to each of two sequences of dental working: receiving feedback or no feedback including the probability of WMSD and related risk factors from the system. The group that received feedback decreased significantly (t-test, p < 0.05) the extensions of neck and upper back in the y-axis as well as the WMSD probability on the post-test. In conclusion, the system for predicting and preventing WMSD aids the correction of neck and upper back extensions and reduction in WMSD probability, which may potentially contribute to reduce the risk of WMSD among dentists.
Posteroventral cochlear nucleus projections to olivocochlear neurons

The presence of ascending auditory inputs from the posteroventral cochlear nucleus (PVCN) to olivocochlear neurons was examined in guinea pig by using the combination Phaseolus vulgaris‐leucoagglutinin (PHA‐L) anterograde and horseradish peroxidase (HRP) retrograde tract‐tracing technique. By labeling the somata of olivocochlear neurons after injection of HRP into the cochlea and simultaneously labeling terminal endings of PVCN efferent neurons after injection of PHA‐L into PVCN, we observed neuronal connections between these two elements within all regions of the superior olivary Complex known to contain olivocochlear neurons. These regions include the superior paraolivary nucleus, medial nucleus of the trapezoid body, lateral superior olive, and periolivary regions. All possible projection patterns regarding side of input and output of both large (four combinations) and small (two combinations) olivocochlear neurons were observed. However, the most frequently observed pattern was the PVCN projection to a contralaterally located and contralaterally projecting, large olivocochlear neuron. Thus the most prevalent pattern demonstrated a feedback pathway that crossed the brainstem twice. Additional patterns demonstrated pathways that fed back to the same cochlea as well as pathways that fed forward to the opposite cochlea.
Trends in mortality from tuberculosis in England and Wales: effect of age on deaths from non-respiratory disease.

BACKGROUND--Although mortality from tuberculosis has continued to fall in recent years, there has been little change in the case fatality rate for tuberculosis over the same period. This has previously been shown to be due to the increasing proportion of cases of tuberculosis occurring in the elderly. Tuberculosis mortality and case fatality were therefore analysed to determine if this disappointing trend in case fatality rate has occurred from disease in all or only certain sites. METHODS--A retrospective analysis of the tuberculosis mortality and case fatality rates in England and Wales for the period 1972-92 was carried out. The average annual percentage change in tuberculosis was calculated for each disease site and by age group and the results were compared. RESULTS--The analysis showed that, although the mortality rate fell steadily by 5.6% per annum, the case fatality rate decreased by only 0.9% (95% CI -1.7 to -0.1) per annum. The case fatality rate for respiratory and central nervous system disease declined, but no decline in tuberculosis at "other" sites was observed (1.01% (+2.2 to -0.2) for all age groups combined). In the group aged 75 and over, however, the proportion of deaths due to disease at other sites increased by 3.2% (2.2 to 4.3) per annum whilst in the other age groups the mortality rate declined. CONCLUSIONS--This analysis suggests that clinicians may be becoming less able to recognise non-respiratory presentations of tuberculosis, particularly in the elderly, and underlines the need to consider tuberculosis as a diagnosis to avoid delay in treatment.
Diversity techniques for mobile radio reception

After discussing the nature of the electromagnetic field in urban environments, and the use of diversity techniques in fading media, the paper presents a survey of these techniques as applied to mobile radio, with emphasis on systems designed for analogue communication. It includes a unified approach to systems based on the double-heterodyne phase-stripper principle. The discussion is not restricted to present-day receivers only, but includes considerations which may apply in future designs.
Distinct CD8+ T Cell Repertoires Primed with Agonist and Native Peptides Derived from a Tumor-Associated Antigen1

Heteroclitic peptides are used to enhance the immunogenicity of tumor-associated Ags to break T cell tolerance to these self-proteins. One such altered peptide ligand (Cap1–6D) has been derived from an epitope in human carcinoembryonic Ag, CEA605–613 (Cap1). Clinical responses have been seen in colon cancer patients receiving a tumor vaccine comprised of this altered peptide. Whether Cap1–6D serves as a T cell agonist for Cap1-specific T cells or induces different T cells is unknown. We, therefore, examined the T cell repertoires elicited by Cap1–6D and Cap1. Human CTL lines and clones were generated with either Cap1–6D peptide (6D-CTLs) or Cap1 peptide (Cap1-CTLs). The TCR Vβ usage and functional avidity of the T cells induced in parallel against these target peptides were assessed. The predominant CTL repertoire induced by agonist Cap1–6D is limited to TCR Vβ1-J2 with homogenous CDR3 lengths. In contrast, the majority of Cap1-CTLs use different Vβ1 genes and also had diverse CDR3 lengths. 6D-CTLs produce IFN-γ in response to Cap1–6D peptide with high avidity, but respond with lower avidity to the native Cap1 peptide when compared with the Cap1-CTLs. Nevertheless, 6D-CTLs could still lyse targets bearing the native epitope. Consistent with these functional results, 6D-CTLs possess TCRs that bind Cap-1 peptide/MHC tetramer with higher intensity than Cap1-CTLs but form less stable interactions with peptide/MHC as measured by tetramer decay. These results demonstrate that priming with this CEA-derived altered peptide ligand can induce distinct carcinoembryonic Ag-reactive T cells with different functional capacities.
Functional recovery of human mesenteric and coronary arteries after cryopreservation at -196 degrees C in a serum-free medium.

PURPOSE Long-term patency of cryopreserved vascular grafts is determined by maintained cellular and tissue viability, which implies preservation of various biochemical, smooth muscle, and endothelial functions. Therefore, it was investigated whether the presence of fetal calf serum (FCS) in the cryomedium improves the postthaw contractile and endothelial function of human arteries. METHODS Rings from human mesenteric (HMA) and left circumflex coronary arteries (HCA) obtained from organ donors were randomized into three groups and studied either unfrozen or after storage for 3 to 6 weeks at -196 degrees C while suspended in Krebs-Henseleit solution without or with 20% FCS as the vehicles and 1.8 mol/L dimethyl sulfoxide and 0.1 mol/L sucrose as cryoprotecting agents. The samples were slowly frozen to -70 degrees C and then stored in liquid nitrogen. Before use, the tissues were thawed within 3 minutes in a 40 degrees C water bath. RESULTS After thawing the sensitivity to various agonists and maximal responses to the endothelium-independent relaxing agent sodium nitroprusside were unchanged. However, after cryopreservation of HMA was performed without and with FCS, maximal contractile responses to noradrenaline were significantly reduced to 10.1 +/- 0.7 gm and 9.9 +/- 0.9 gm compared with 13.3 +/- 0.6 gm in unfrozen HMA (mean +/- SEM, n = 15). After cryopreservation of HCA was performed without and with FCS, maximal contractile responses to prostaglandin F2 alpha (6.9 +/- 0.4 gm in unfrozen HCA) were significantly reduced to 4.3 +/- 0.3 gm and 3.8 +/- 0.2 gm (mean +/- SEM, n = 6). In both types of arteries cryopreservation also attenuated significantly the endothelium-dependent relaxant responses to bradykinin during U46619 (10 nmol/L)-induced tone. In HMA the maximal bradykinin-induced relaxation (85% +/- 4%) was significantly diminished to 29% +/- 7% and 38% +/- 9% after cryopreservation without and with FCS (mean +/- SEM, n = 6). In HCA maximal bradykinin-induced relaxation (88% +/- 4%) was significantly diminished to 26% +/- 10% and 36% +/- 11% after cryopreservation without and with FCS (mean +/- SEM, n = 6). This result was reflected by a marked endothelial denudation in all groups of cryopreserved arteries. Neither functional nor morphologic preservation of the endothelial cell lining was significantly improved by FCS supplementation of the cryomedium. CONCLUSIONS Cryopreservation diminished contractile and endothelium-dependent relaxant responses of human arteries. The presence of FCS in the cryomedium did not modify these changes.