Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparative Study of Chronic Kidney Disease Prediction using KNN and SVM

— Chronic kidney disease (CKD), also known as chronic renal disease. Chronic kidney disease involves conditions that damage your kidneys and decrease their ability to keep you healthy. You may develop complications like high blood pressure, anemia (low blood count), weak bones, poor nutritional health and nerve damage. Early detection and treatment can often keep chronic kidney disease from getting worse. Data Mining is the term used for knowledge discovery from large databases. The task of data mining is to make use of historical data, to discover regular patterns and improve future decisions, follows from the convergence of several recent trends: the lessening cost of large data storage devices and the ever-increasing ease of collecting data over networks; the expansion of robust and efficient machine learning algorithms to process this data; and the lessening cost of computational power, enabling use of computationally intensive methods for data analysis. Machine learning, has already created practical applications in such areas as analyzing medical science outcomes, detecting fraud, detecting fake users etc. Various data mining classification approaches and machine learning algorithms are applied for prediction of chronic diseases. The objective of this research work is to introduce a new decision support system to predict chronic kidney disease. The aim of this work is to compare the performance of Support vector machine (SVM) and K-Nearest Neighbour (KNN) classifier on the basis of its accuracy, precision and execution time for CKD prediction. From the experimental results it is observed that the performance of KNN classifier is better than SVM.
The Turkish Version of the Breastfeeding Attrition Prediction Tool

This study demonstrates that the original English version of the Breastfeeding Attrition Prediction Tool (BAPT) was successfully adapted to Turkey, as methodologically demonstrated here. The results of this study show that the Turkish version of the BAPT is similar to the original version and that it can be used with Turkish women to identify mothers who may be at high risk of weaning prematurely.
Reduction in IL-33 expression exaggerates ischaemia/reperfusion-induced myocardial injury in mice with diabetes mellitus.

AIMS The underlying mechanism(s) of vulnerability of the diabetic myocardium to ischaemia/reperfusion (I/R)-induced injury is not fully understood. Interleukin-33 (IL-33) has been reported showing the beneficial effect to the myocardium on I/R injury. The aims of this study were to test whether diabetes mellitus (DM) affects myocardial levels of IL-33 and to examine whether reduction in IL-33 is responsible for exaggerated I/R injury in the diabetic myocardium. METHODS AND RESULTS DM hearts were challenged with I/R in vivo, whereas while isolated cardiomyocytes in vitro were conditioned with high glucose (HG) followed by an anoxia/reoxygenation (A/R) challenge. Myocardial levels of IL-33 were decreased in mice with DM which was associated with increased protein kinase C βII (PKCβII) activation. Exogenous IL-33 prevented the DM-induced PKCβII activation and attenuated I/R injuries (myocardial infarction size and apoptosis). HG-conditioned myocytes incurred exaggerated apoptosis when compared with naïve myocytes after A/R which was attenuated by IL-33. HG activated PKCβII in cardiomyocytes, which was further enhanced by A/R. IL-33 prevented the PKCβII activation in myocytes with HG or HG and A/R. Inhibition of PKCβII prevented the beneficial effect of IL-33. Finally, IL-33 up-regulated diacylglycerol kinase zeta (DGK-zeta) in cardiomyocytes and reversed the down-regulation of myocardial DGK-zeta in mice with DM. CONCLUSION Our results indicate that decreased levels of IL-33 are responsible for the increased sensitivity of the myocardium to I/R in DM. Reduction in IL-33 results in a chronic activation of PKCβII. I/R further enhances PKCβII activation in the diabetic myocardium which results in exaggeration of myocardial injury.
Development of multiplex microsatellite PCR panels for the seagrass Thalassia hemprichii (Hydrocharitaceae)1

Premise of the study: New microsatellites were developed for the seagrass Thalassia hemprichii (Hydrocharitaceae), a long-lived seagrass species that is found throughout the shallow waters of tropical and subtropical Indo-West Pacific. Three multiplex PCR panels were designed utilizing new and previously developed markers, resulting in a toolkit for generating a 16-locus genotype. Methods and Results: Through the use of microsatellite enrichment and next-generation sequencing, 16 new, validated, polymorphic microsatellite markers were isolated. Diversity was between two and four alleles per locus totaling 36 alleles. These markers, plus previously developed microsatellite markers for T. hemprichii and T. testudinum, were tested for suitability in multiplex PCR panels. Conclusions: The generation of an easily replicated suite of multiplex panels of codominant molecular markers will allow for high-resolution and detailed genetic structure analysis and clonality assessment with minimal genotyping costs. We suggest the establishment of a T. hemprichii primer convention for the unification of future data sets.
(+/-)-7alpha,8beta-dihydroxy-9beta,10beta-epoxy-7,8,9,10-tetrahydrobenzo(a)-pyrene is an intermediate in the metabolism and binding to DNA of benzo(a)pyrene.

The addition of borate buffer to the aqueous methanol used to elute hydrocarbon-deoxyribonucleoside derivatives from an LH 20 Sephadex column resulted in the separation of the products of reaction with DNA of the stereoisomers, (+/-)7alpha,8beta-dihydroxy-9alpha,10alpha-epoxy- and (+/-)-7alpha,8beta-dihydroxy-9beta,10beta-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrenes, i.e., the syn- and anti-benzo(a)pyrene-diolepoxide, respecitvely. By this technique it was shown that the microsome-mediated binding to DNA of benzo(a)pyrene-7,8-dihydrodiol involved exclusively the anti-benzo(a)pyrene-diolepoxide. The benzo(a)pyrene binding to DNA that resulted on exposure of BHK21/C13 cells to this carcinogen was also shown to result predominantly by reaction of the anti-benzo(a)pyrene-diolepoxide. However, in this case other derivatives, including the syn-benzo(a)pyrene diolepoxide, might also be involved.
Alternative bone expansion technique for immediate placement of implants in the edentulous posterior mandibular ridge: a clinical report.

PURPOSE The aim of this study was to evaluate the effectiveness of a split-crest bone augmentation technique performed for immediate implant placement in thin edentulous posterior mandibular ridges. MATERIALS AND METHODS In the present study, 125 implants were placed in posterior mandibular ridges of 30 patients. The mandibular buccal walls were split, expanded, and grafted with a combination of platelet-rich plasma and Cerasorb. The split segments were held in place by cortical bone screws. Before loading, periodontal status was checked, implant stability was evaluated with the Periotest, and panoramic radiographs and computerized tomography scans were obtained. Second-stage surgery (cover screw removal and healing abutment placement) was performed after 3 to 4 months. RESULTS All implants osseointegrated successfully and underwent loading after 4 months. Optimal healing occurred 3 to 4 months earlier than the usual 6 to 9 months required, and no lip paresthesia was noted. DISCUSSION Although onlay-inlay grafts, sandwich osteotomies, guided bone regeneration, piezoelectricity, and alveolar distraction have been indicated for augmentation in the posterior mandibular region, each of these techniques involves risks and complications. The crest-splitting bone expansion technique enables single-stage immediate implant placement and lateral ridge augmentation in thin crests and may prevent neurosensorial deficiencies. CONCLUSIONS The split-crest surgical technique is a valid reconstructive procedure for sharp posterior mandibular ridges. If performed using platelet-rich plasma and Cerasorb, it can shorten the osseointegration period.
Gender Differences and Moderators Women Are More Likely Than Men to Use Tentative Language , Aren ' t They ? A Meta-Analysis Testing for

Robin Lakoff proposed that women are more likely than men to use tentative speech forms (e.g., hedges, qualifiers/disclaimers, tag questions, intensifiers). Based on conflicting results from research testing Lakoff’s claims, a meta-analysis of studies testing gender differences in tentative language was conducted. The sample included 29 studies with 39 independent samples and a combined total sample of 3,502 participants. Results revealed a statistically significant but small effect size (d 1⁄4 .23), indicating that women were somewhat more likely than men to use tentative speech. In addition, methodological moderators (operational definition, observation length, recording method, author gender, and year of study) and contextual moderators (gender composition, familiarity, student status, group size, conversational activity, and physical setting) were tested. Effect sizes were significantly larger in studies that (a) observed longer (vs. shorter) conversations, (b) sampled undergraduates (vs. other adults), (c) observed groups (vs. dyads), and (d) occurred in research labs (vs. other settings). The moderator effects are interpreted as supporting proposals that women’s greater likelihood of tentative language reflects interpersonal sensitivity rather than a lack of assertiveness. In addition, the influence of self-presentation concerns in the enactment of gender-typed behavior is discussed.
Look-Up tables with multiple inputs for secured-by-design FPGAs

We introduce a set of circuit techniques that make the dynamic and static power consumptions of multiple-input Look-Up Tables (LUT) independent of both the input data and FPGA configuration. This feature provides intrinsic robustness to dynamic and static power attacks. We also show that the proposed circuitry exhibits a monotonic response, which makes the FPGA robust to early evaluation attacks and those based on glitches. This quadruple robustness of the secured FPGA implementation is achieved while the FPGA configurability is fully maintained. The silicon area overhead is in line with the industrial and academic prior art, which means that the secured FPGA can be very attractive to cryptosystems developers.
Effects of precommercial thinning and midstory control on avian and small mammal communities during longleaf pine Savanna restoration

Restoring longleaf pine (Pinus palustris Mill.) savanna is a goal of many southern land managers, and longleaf plantations may provide a mechanism for savanna restoration. However, the effects of silvicultural treatments used in the management of longleaf pine plantations on wildlife communities are relatively unknown. Beginning in 1994, we examined effects of longleaf pine restoration with plantation silviculture on avian and small mammal communities using four treatments in four 8- to 11- year-old plantations within the Savannah River Site in South Carolina. Treatments included prescribed burning every 3 to 5 years, plus: (1) no additional treatment (burn-only control); (2) precommercial thinning; (3) non-pine woody control with herbicides; and (4) combined thinning and woody control. We surveyed birds (1996-2003) using 50-m point counts and small mammals with removal trapping. Thinning and woody control alone had short-lived effects on avian communities, and the combination treatment increased avian parameters over the burn-only control in all years. Small mammal abundance showed similar trends as avian abundance for all three treatments when compared with the burn-only control, but only for 2 years post-treatment. Both avian and small mammal communities were temporarily enhanced by controlling woody vegetation with chemicals in addition to prescribed fire and thinning.Therefore, precommercial thinning in longleaf plantations, particularly when combined with woody control and prescribed fire, may benefit early-successional avian and small mammal communities by developing stand conditions more typical of natural longleaf stands maintained by periodic fire.
Complete Genome Sequence of Pseudomonas balearica DSM 6083T

ABSTRACT The whole-genome sequence of Pseudomonas balearica SP1402 (DSM 6083T) has been completed and annotated. It was isolated as a naphthalene degrader from water of a lagooning wastewater treatment plant. P. balearica strains tolerate up to 8.5% NaCl and are considered true marine denitrifiers.
Hyperthermia as an adjuvant therapy to chemotherapy for the treatment of advanced ovarian cancer complicated by ascites

In this study, the efficacy of hyperthermia as an adjuvant treatment was assessed for patients with advanced epithelial ovarian cancer complicated by ascites. Forty-eight patients with advanced ovarian cancer and ascites were randomly assigned to two groups. Group A was treated with both hyperthermia (BSD-2000 Hyperthermia System) and chemotherapy (the GT regimen). Group B was treated only with the GT regimen. The curative effects, side effects, Karnofsky Performance Score (KPS), and immune indexes were assessed after two cycles of treatment for both groups. The response rate of Group A was significantly higher than that of Group B (50.0% vs. 25.0%, P<0.05). The median progression-free survival time for Group A was 8.2 months, as compared to 4.8 months for Group B (P<0.05). There was no significant difference between the groups in the disease control rate, overall survival, or improvement in the KPS score. Compared with Group B, the number of CD3+, CD4+, and CD8+ cells in Group A increased remarkably, while the CD4+/CD8+ ratio declined after the treatment (P<0.05 for all). These results suggest that hyperthermia is a promising adjuvant therapy for late-stage ovarian cancer. A future large-scale randomized clinical trial is warranted to confirm this conclusion.
THE BARYONIC TULLY–FISHER RELATION OF GAS-RICH GALAXIES AS A TEST OF ΛCDM AND MOND

The baryonic Tully–Fisher relation (BTFR) is an empirical relation between baryonic mass and rotation velocity in disk galaxies. It provides tests of galaxy formation models in ΛCDM and of alternative theories like modified Newtonian dynamics (MOND). Observations of gas-rich galaxies provide a measure of the slope and normalization of the BTFR that is more accurate (if less precise) than that provided by star-dominated spirals, as their masses are insensitive to the details of stellar population modeling. Recent independent data for such galaxies are consistent with Mb = AV 4 f with A = 47 ± 6 M ☉ km−4 s4. This is equivalent to MOND with a 0 = 1.3 ± 0.3 Å s−2. The scatter in the data is consistent with being due entirely to observational uncertainties. It is unclear why the physics of galaxy formation in ΛCDM happens to pick out the relation predicted by MOND. We introduce a feedback efficacy parameter to relate halo properties to those of the galaxies they host. correlates with star formation rate and gas fraction in the sense that galaxies that have experienced the least star formation have been most impacted by feedback.
Plant Mitochondrial Genome Evolution Can Be Explained by DNA Repair Mechanisms

Plant mitochondrial genomes are notorious for their large and variable size, nonconserved open reading frames of unknown function, and high rates of rearrangement. Paradoxically, the mutation rates are very low. However, mutation rates can only be measured in sequences that can be aligned—a very small part of plant mitochondrial genomes. Comparison of the complete mitochondrial genome sequences of two ecotypes of Arabidopsis thaliana allows the alignment of noncoding as well as coding DNA and estimation of the mutation rates in both. A recent chimeric duplication is also analyzed. A hypothesis is proposed that the mechanisms of plant mitochondrial DNA repair account for these features and includes different mechanisms in transcribed and nontranscribed regions. Within genes, a bias toward gene conversion would keep measured mutation rates low, whereas in noncoding regions, break-induced replication (BIR) explains the expansion and rearrangements. Both processes are types of double-strand break repair, but enhanced second-strand capture in transcribed regions versus BIR in nontranscribed regions can explain the two seemingly contradictory features of plant mitochondrial genome evolution—the low mutation rates in genes and the striking expansions of noncoding sequences.
Assessing pain in cognitively impaired older adults.

BACKGROUND Accurate assessments of pain help healthcare professionals to identify its source and manage it appropriately. Pain in cognitively impaired older adults is difficult to assess and this can result in poor management and outcomes. In response to the vulnerability of this patient group, researchers have produced a variety of tools for pain assessment in cognitively impaired older adults. CONCLUSION Replication research is recommended to validate further and generalize results, although there is enough evidence to support the use of direct observation of behaviour in identifying pain in this group of patients.
Size and Shape Variability in Human Molars during Odontogenesis

Under the patterning cascade model (PCM) of cusp development inspired by developmental genetic studies, it is predicted that the location and the size of later-forming cusps are more variable than those of earlier-forming ones. Here we assessed whether differences in the variability among cusps in total and each particular crown component (enamel-dentin junction [EDJ], outer enamel surface [OES], and cement-enamel junction [CEJ]) could be explained by the PCM, using human maxillary permanent first molars (UM1) and second deciduous molars (um2). Specimens were µCT-scanned, and 3D models of EDJ and OES were reconstructed. Based on these models, landmark-based 3D geometric morphometric analyses were conducted. Size variability in both tooth types was generally consistent with the above prediction, and the differences in size variation among cusps were smaller for the crown components completed in later stages of odontogenesis. With a few exceptions, however, the prediction was unsupported regarding shape variability, and UM1 and um2 showed different patterns. Our findings suggested that the pattern of size variability would be caused by temporal factors such as the order of cusp initiation and the duration from the beginning of mineralization to the completion of crown formation, whereas shape variability may be affected by both topographic and temporal factors.
Beck Depression Inventory as a Predictor of Long-term Outcome Among Patients Admitted to the Breast Cancer Diagnosis Unit: A 25-year Cohort Study in Finland.

AIM The Beck Depression Inventory (BDI) is one of the most widely used instruments for measuring the severity of depression. However, there has been no prospective study to investigate the long-term outcome in patients admitted to Breast Cancer Diagnosis Units. PATIENTS AND METHODS In the Kuopio Breast Cancer Study, women with breast symptoms were evaluated for total BDI score before any diagnostic procedures were carried out. The relapse-free survival (RFS) was calculated from the time of diagnosis to the time of first relapse including local relapse, contralateral breast cancer (BC) or metastatic disease. The overall survival (OS) was assessed as the time from the date of diagnosis to the date of last follow-up or death of the patient. The effect of the BDI on the RFS and on the OS were calculated by the Kaplan-Meier survival analysis and the difference between the groups was assessed by the log-rank test. The RFS and OS was estimated for the study groups with a low BDI score (<8) versus those with a high BDI score (≥8). The end-point of our study was to determine differences in long-term outcome and in BDI score in individuals with BC, benign breast disease (BBD) and in healthy study subjects (HSS). RESULTS In the Cox proportional hazard model, the total BDI score significantly predicted the 25-year RFS and OS in the HSS, BBD and BC groups combined (Hazard Ratio=1.87, p=0.039; Hazard Ratio=1.98, p=0.048, respectively), and in the Kaplan-Meier survival analysis with the log-rank test, the total BDI score predicted the 25-year RFS and OS in the HSS, BBD and BC groups combined (p=0.043; p=0.036, respectively). CONCLUSION The BDI is a significant predictor of long-term outcome among patients admitted to the Breast Cancer Diagnosis Unit in Finland.
Collaboration Between General Practitioners and Occupational Physicians: A Comparison of the Results of Two National Surveys in France

Objective: To study the perceptions that general practitioners (GPs) and occupational physicians (OPs) have of GPs' role in occupational health and their willingness to work together to prevent the exclusion of patients with disabilities from the workplace. Methods: Cross-sectional telephone survey of two randomly selected national samples of GPs and OPs was conducted. Results: The majority of GPs and OPs are in favor of cooperation, especially to prevent exclusion from the workplace. However, some GPs lack trust in OPs' independence, an attitude associated negatively with the practice of GP referral to OPs to anticipate disability-related problems likely to occur when returning to work after a prolonged sick leave. Conclusions: There are some barriers to cooperation, on the part of both OPs and GPs. Initiatives are needed to encourage cooperation between these two types of physicians.
Host‐specific aphid population responses to elevated CO2 and increased N availability

Sap‐feeding insects such as aphids are the only insect herbivores that show positive responses to elevated CO2. Recent models predict that increased nitrogen will increase aphid population size under elevated CO2, but few experiments have tested this idea empirically. To determine whether soil nitrogen (N) availability modifies aphid responses to elevated CO2, we tested the performance of Macrosiphum euphorbiae feeding on two host plants; a C3 plant (Solanum dulcamara), and a C4 plant (Amaranthus viridis). We expected aphid population size to increase on plants in elevated CO2, with the degree of increase depending on the N availability.
unc5c haploinsufficient phenotype: striking similarities with the dcc haploinsufficiency model

DCC and UNC5 homologs (UNC5H) are guidance cue receptors highly expressed by mesocorticolimbic dopamine neurons. We have shown that dcc heterozygous mice exhibit increased dopamine, but not norepinephrine, innervation and function in medial prefrontal cortex. Concomitantly, dcc heterozygotes show blunted mesolimbic dopamine release and behavioral responses to stimulant drugs. These changes appear only in adulthood. Recently, we found an adolescent emergence of UNC5H expression by dopamine neurons and co‐expression of DCC and UNC5H by single dopamine cells. Here, we demonstrate selective expression of unc5 homolog c mRNA by dopamine neurons in adulthood. We show that unc5c haploinsufficiency results in diminished amphetamine‐induced locomotion in male and female mice. This phenotype is identical to that produced by dcc haploinsufficiency and is observed after adolescence. Notably, and similar to dcc haploinsufficiency, unc5c haploinsufficiency leads to dramatic increases in tyrosine hydroxylase expression in the medial prefrontal cortex, but not in the nucleus accumbens. In contrast, medial prefrontal cortex dopamine‐β‐hydroxylase expression is not altered. We confirmed that UNC5C protein is reduced in the ventral tegmental area of unc5c heterozygous mice, but that DCC expression in this region remains unchanged. UNC5C receptors may also play a role in dopamine function and influence sensitivity to behavioral effects of stimulant drugs of abuse, at least upon first exposure. The striking similarities between the dcc and the unc5c haploinsufficient phenotypes raise the possibility that functions mediated by DCC/UNC5C complexes may be at play.