Miracle-dz/UniFAR-FTUs huggingface dataset:
Learning Domain-Specific Sentiment Lexicons for Predicting Product Sales

Generic sentiment lexicons have been widely used for sentiment analysis these days. However, manually constructing sentiment lexicons is very time-consuming and it may not be feasible for certain application domains where annotation expertise is not available. One contribution of this paper is the development of a statistical learning based computational method for the automatic construction of domain-specific sentiment lexicons to enhance cross-domain sentiment analysis. Our initial experiments show that the proposed methodology can automatically generate domain-specific sentiment lexicons which contribute to improve the effectiveness of opinion retrieval at the document level. Another contribution of our work is that we show the feasibility of applying the sentiment metric derived based on the automatically constructed sentiment lexicons to predict product sales of certain product categories. Our research contributes to the development of more effective sentiment analysis system to extract business intelligence from numerous opinionated expressions posted to the Web.
Impact of Domain Modeling Techniques on the Quality of Domain Model: An Experiment

The unified modeling language (UML) is widely used to analyze and design different software development artifacts in an object oriented development. Domain model is a significant artifact that models the problem domain and visually represents real world objects and relationships among them. It facilitates the comprehension process by identifying the vocabulary and key concepts of the business world. Category list technique identifies concepts and associations with the help of pre defined categories, which are important to business information systems. Whereas noun phrasing technique performs grammatical analysis of use case description to recognize concepts and associations. Both of these techniques are used for the construction of domain model, however, no empirical evidence exists that evaluates the quality of the resultant domain model constructed via these two basic techniques. A controlled experiment was performed to investigate the impact of category list and noun phrasing technique on quality of the domain model. The constructed domain model is evaluated for completeness, correctness and effort required for its design. The obtained results show that category list technique is better than noun phrasing technique for the identification of concepts as it avoids generating unnecessary elements i.e. extra concepts, associations and attributes in the domain model. The noun phrasing technique produces a comprehensive domain model and requires less effort as compared to category list. There is no statistically significant difference between both techniques in case of correctness.
Zinc chelation enhances the sensitivity of the ERG b-wave in dark-adapted skate retina.

A decade ago, Wu et al. reported evidence of a dense band of ionic zinc in the region of the photoreceptor terminals of the salamander retina (1). They speculated that zinc may play a neuromodulatory role in the outer retina, including possible feedback onto photoreceptors to down-regulate transmitter release, as well as feedforward onto second order cells. Subsequently, a high ionic zinc concentration was identifi ed in a similar region near the base of the photoreceptors in the all-rod retina of the skate (2). In addition, Ugarte and Osborne (3) have reported recently that a dense band of ionic zinc, located in the photoreceptor region of the light-adapted rat retina, is redistributed under dark-adapted conditions. Zinc has been known to affect the response of receptors on a number of retinal cell types to various neurotransmitters (4). In the skate, zinc regulates both GABA (2) and glutamate (5) receptors of isolated cells. Furthermore, the zinc chelator histidine (an amino acid endogenous in the retina, where it may play various roles in cell metabolism and disease (6, 7, 8, 9, 10)) has been shown to enhance the size of the b-wave of the electroretinogram (ERG) of the skate (5) and zebrafi sh (11). Histidine can also increase the membrane currents recorded postsynaptically from horizontal cells during voltage-clamp in the skate retinal slice preparation (12). The effects of histidine support the notion that endogenous zinc may be playing a role in the physiological response of the retina to light. Recent studies of the effects of histidine on the zebra fi sh ERG have demonstrated an increase in sensitivity of its mixed rod-cone retina in the presence of a zinc chelator (11). Here, we report studies of the effect of histidine on the retina of the skate, Raja erinacea, indicating that application of this zinc chelator enhances the sensitivity of the b-wave of the ERG in an all-rod retina. Skates were obtained through the Marine Resources Center of the Marine Biological Laboratory (Woods Hole, MA). The animals were allowed to dark-adapt for at least one hour prior to an experiment. After approved euthanasia, the eyes were enucleated and dissected under dim red light. The anterior portion of the eye, including cornea and lens, was removed; and the remaining retinal eyecup preparation was used for ERG recordings. Eyecups were placed into a chamber over a silver chloride reference electrode within a Faraday cage. The active silver chloride electrode was connected to superfusion solutions in the eyecup via a glass capillary containing Ringer/agar. ERG responses to increasing intensities of illumination were recorded while the preparation was superfused (0.5 ml/min) with skate-modifi ed Ringer’s solution (2) alone, or to which 200 M picrotoxin (to block GABAergic receptors in the retina known to be zinc-sensitive (2)), and then 100 M histidine plus 200 M picrotoxin had been added. We had found that responses in picrotoxin did not increase after the fi rst 10
Hormone therapy modulates ETA mRNA expression in the aorta of ovariectomised New Zealand White rabbits

Objective. To study the effect of 17β-estradiol (E2) or conjugated equine estrogens (CEE) alone and in combination with norethisterone acetate (NETA) or medroxyprogesterone acetate (MPA) on the endothelin-1 (ET-1) system. Methods. New Zealand White rabbits were treated with E2, CEE, E2 + NETA, CEE + MPA or placebo. The thoracic aorta and the epicardial coronary artery were used for mRNA expression and myograph analyses, respectively. Results. E2 and CEE alone significantly reduced ET-1 receptor subtype A (ETA) mRNA expression compared with placebo treatment. The E2-induced reduction in ETA mRNA expression persisted with the co-administration of NETA, but the CEE induced reduction in ETA mRNA expression was not maintained with the co-administration of MPA. Treatment with CEE alone significantly increased endotelin-1 converting enzyme (ECE) mRNA expression and CEE combined with MPA reduced prepro-endothelin-1 (ppET-1) mRNA expression when compared with placebo. ET-1 receptor subtype B mRNA expression and ET-1 induced vasocontraction was unaffected by treatment. Conclusions. E2 and CEE treatment exert potentially beneficial vascular effects through regulation of the ETA receptor. The effect was maintained with the co-administration of NETA, but not MPA. The differential effects of specific hormone components may explain the variable effects of hormone therapy on the arterial wall.
A nucleation–elongation mechanism for the self‐assembly of side polar sheets of smooth muscle myosin.

Self‐assembled filaments of smooth muscle myosin were observed by low dose electron microscopy to be flat side‐polar sheets, in which the component molecules appeared straight and close‐packed. Fraying experiments released small oligomers, in which molecules were staggered in parallel by about +/‐ 14 nm relative to two immediate neighbours, and were bound also to an antiparallel partner via a approximately 14 nm overlap at the very tip of the tail. We suggest a filament model which preserves these packing relationships. Adding stoichiometric amounts of MgATP to the filaments caused them to disassemble completely by progressive loss of material from their ends, at a limiting rate equivalent to about 2 monomers per second per end in physiological saline. The rate of the competing association reaction varied linearly with the monomer concentration, as determined in pressure‐jump experiments. This suggests that myosin monomers, rather than dimers or higher oligomers, are the building blocks of these filaments. Shearing and annealing of assembled filaments appeared negligible on a time scale of a few hours. In consequence, filament number and filament length were dependent on the rate at which monomers were supplied to the assembly reaction, and on the number of filaments already present at the start of the assembly reaction.
Spinal opioids and the prevention of postdural puncture headache

1 Doyle A, Wilkinson D. Day case general anaesthesia in a patient with narcolepsy. Anaesthesia 2008; 63: 880–2. 2 Saper CB. Staying awake for dinner: hypothalamic integration of sleep, feeding and circadian rhythms. Progress in Brain Research 2006; 153: 243–52. 3 Thorpy M. Sodium oxybate for the treatment of narcolepsy. Expert Opinion on Pharmacotherapy 2005; 6: 329–35. 4 Black J, Houghton WC. Sodium oxybate improves excessive daytime sleepiness in narcolepsy. Sleep 2006; 29: 939–46. 5 Kam PCA, Yoong FFY. Gammahydroxybutyric acid: an emerging recreational drug. Anaesthesia 1998; 53: 1195–8.
Parameter Estimation of Permanent-Split Capacitor-Run Single-Phase Induction Motor Using Computed Complex Voltage Ratio

Equivalent circuit parameters and performance variables of permanent-split capacitor-run single-phase induction motor can be obtained from dc test, no-load test, locked-rotor test, and using turns ratio as derived from the winding ratio test (the last one is carried out if the design data are not available). In this paper, turns ratio has been replaced by a computed complex voltage ratio, based on an assumption that single-phase motor for parameter transformation can be represented as an ideal transformer. The equations for this complex quantity have been derived that provide an alternative to winding ratio test, which otherwise requires the tedium of a physical test on the motor. The performance variables like input current, power factor, and power consumed by the motor, obtained by the proposed technique, have been compared with those obtained using the conventional techniques as well as with the experimental observations obtained on three fan motors of different ratings. It is observed that the proposed method gives performance variable values closer to the experimental observations in comparison to those obtained using the conventional methods.
Multi-thread security constraint economic dispatch with exact loss formulation

This paper proposes a new method for solving economic dispatch problems in electrical power systems through the application of multithread programming. Multi-Thread Interior Point Barrier Algorithm, an efficient quadratic programming algorithm, is used to solve economic dispatch problem. The barrier algorithm also caters for any combination of polynomial functions such as polynomial cost functions. Nonlinear characteristics of electrical power system such as generators limitations, transmission losses and nonlinear cost functions are considered in the economic dispatch formulation. Exact transmission loss formula is used in the equality constraint in the economic dispatch equations. The transmission loss coefficients are calculated by using a multi-thread programming. To ensure the optimal dispatch satisfies the line flow limits, line flow constraints has been added to formulation as a security constraint. This optimization problem enable us to solve economic dispatch problems faster, so it is suitable for unit commitment problems and the other power system problems which need to get reasonable speed. IEEE 30, 57, 118 bus case studies are presented and tested with the proposed method.
Ischaemic heart disease and cholesterol Safety of cholesterol reduction remains in doubt

EDITOR, - At their core the papers by M R Law and colleagues are about the advisability of reducing the cholesterol concentration in the general population, principally through restriction of dietary fat. *RF 1-3* This primary prevention mandate is plagued by controversies, while consensus exists for lowering cholesterol in patients with coronary heart disease. What, then, do the papers add to the issues surrounding population based dietary treatment to lower serum cholesterol concentrations? With respect to evidence that a low cholesterol concentration is associated with increased mortality from causes other than coronary heart disease Law and colleagues emphasise that these relations are seen exclusively in community based populations rather than in (typically smaller) cohorts based on occupation. They assert that illness present at entry to community based studies caused a fall in cholesterol concentrations. The authors fail to recognise, however, that the largest “community based” cohort was in fact recruited primarily from employee groups.4 Moreover, no evidence is presented that more illness existed in community samples, that these conditions preceded a fall in cholesterol concentration in people healthy enough to volunteer for participation, and that such illnesses account for the associations with mortality. Quantitative attempts to …
Therapeutic strategies and surgical results for pineal region tumours

Until recently, surgery for pineal region tumours has met with poor results. Although experience remains limited, developments in imaging, surgical approaches, and microsurgery have improved outcomes. Over 26 years we treated 36 patients including: 24 with germinoma; four, teratoma; three, pineal cyst; and one each, embryonal carcinoma, choriocarcinoma, pineocytoma, pineoblastoma and metastasis. All 24 germinomas responded to radiotherapy, as did one case each for teratoma, pineoblastoma, and choriocarcinoma. Eight patients underwent resection, and one patient with germinoma had biopsy via endoscopy. Occipital transtentorial and parieto-occipital transcallosal approaches were used in three each, and infratentorial supracerebellar and a combined infratentorial supracerebellar and occipital transtentorial approach in one each. Total removal was achieved in four patients (50%), and subtotal removal in two. Postoperative complications resolved within 2 weeks. Two patients had recurrence and one had dissemination. All tumours except germinomas should be explored and diagnosed histologically. Current operative techniques allow safe, effective removal of pineal region tumours.
Membrane and Integrative Nuclear Fibroblastic Growth Factor Receptor (FGFR) Regulation of FGF-23*

Background: Mechanisms whereby local bone-derived factors regulate FGF-23 are unclear. Results: Low and high molecular weight FGF-2 stimulated FGF-23 promoter activity in osteoblasts through membrane FGFR-mediated PLCγ and MAPK activation of NFAT and Ets1 and integrative nuclear FGFR1 signaling involving cAMP/CBP/CREB signaling pathways, respectively. Conclusion: Membrane FGFR and intranucelar FGFR/CBP pathways regulate FGF-23 transcription. Significance: Paracrine/autocrine FGFs control hormonal FGF-23. Fibroblastic growth factor receptor 1 (FGFR1) signaling pathways are implicated in the regulation of FGF-23 gene transcription, but the molecular pathways remain poorly defined. We used low molecular weight (LMW, 18 kDa) FGF-2 and high molecular weight (HMW) FGF-2 isoforms, which, respectively, activate cell surface FGF receptors and intranuclear FGFR1, to determine the roles of membrane FGFRs and integrative nuclear FGFR1 signaling (INFS) in the regulation of FGF-23 gene transcription in osteoblasts. We found that LMW-FGF-2 induced NFAT and Ets1 binding to conserved cis-elements in the proximal FGF-23 promoter and stimulated FGF-23 promoter activity through PLCγ/calcineurin/NFAT and MAPK pathways in SaOS-2 and MC3T3-E1 osteoblasts. In contrast, HMW-FGF-2 stimulated FGF-23 promoter activity in osteoblasts through a cAMP-dependent binding of FGFR1 and cAMP-response element-binding protein (CREB) to a conserved cAMP response element (CRE) contiguous with the NFAT binding site in the FGF-23 promoter. Mutagenesis of the NFAT and CRE binding sites, respectively, inhibited the effects of LMW-FGF-2 and HMW-FGF-23 to stimulate FGF-23 promoter activity. FGF-2 activation of both membrane FGFRs and INFS-dependent FGFR1 pathways may provide a means to integrate systemic and local regulation of FGF-23 transcription under diverse physiological and pathological conditions.
Pre-Existing Glomerular Immune Complexes Induce Polymorphonuclear Cell Recruitment Through an Fc Receptor-Dependent Respiratory Burst: Potential Role in the Perpetuation of Immune Nephritis 1

In immune complex (IC) diseases, FcR are essential molecules facilitating polymorphonuclear cell (PMN) recruitment and effector functions at the IC site. Although FcR-dependent initial tethering and FcR/integrin-dependent PMN accumulation were postulated, their underlying mechanisms remain unclear. We here addressed potential mechanisms involved in PMN recruitment in acute IC glomerulonephritis (nephrotoxic nephritis). Since some renal cells may be recruited from bone marrow (BM) lineages, reconstitution studies with BM chimeras and PMN transfer between wild-type (WT) and FcR-deficient mice (γ−/−) were performed. Severe glomerular damage was induced in WT and Wγ chimeras (BM from WT to irradiated γ−/−), while it was absent in γ−/− and γW chimeras (γ−/− BM to WT). Moreover, WT PMN transfer, but not γ−/− PMN, reconstituted the disease in γ−/−, indicating that FcR on resident cells is not a prerequisite for PMN recruitment in this disease. Surprisingly, transferred WT PMN were recruited coincidentally with NF-κB activation and TNF-α overexpression even in glomeruli with preformed IC (nephrotoxic Ab administered 3 days previously), suggesting that PMN can initially be recruited via its own FcR without previous chemoattractant release. Furthermore, H2O2 inhibition by catalase attenuated the acute WT PMN recruitment and the induction of NF-κB and TNF-α much more than integrin (CD18) blockade, indicating a role for the respiratory burst before integrin-dependent accumulation. In coculture experiments with IC-stimulated PMN and glomeruli, PMN caused acute glomerular TNF-α expression predominantly via FcR-mediated H2O2 production. In conclusion, glomerular IC, even preformed, can cause PMN recruitment and injury through PMN FcR-mediated respiratory burst during initial PMN tethering to IC.
Automated Bidirectional Languages Localization Testing for Android Apps with Rich GUI

Mobile apps are everywhere. The release of apps on a worldwide scale requires them to be made available in many languages, including bidirectional languages. Developers and translators are usually different persons. While automatic testing by itself is important in general in order to be able to develop high quality software, such automatic tests become absolutely essential when developers that do not possess enough knowledge about right-to-left languages need to maintain code that is written for bidirectional languages. A few bidirectional localization tests of mobile applications exist. However, their functionality is limited since they only cover translations and adoption of locales. In this paper we present our approach for automating the bidirectional localization testing for Android applications with a complete consideration for BiDi-languages issues. The objective is to check for any localization defects in the product. The proposed methods are used to test issues of bidirectional apps in general and specifically for the Arabic language. The results show that the methods are able to effectively reveal deficiencies in the app’s design, ensure that the localized app matches all expectations of local users, and guarantee that the product is culturally congruent to local conventions.
Epidural test dose with levobupivacaine and ropivacaine: determination of ED(50) motor block after spinal administration.

BACKGROUND When a test is required to detect a possible intrathecal catheter, many would seek to use the same local anaesthetic as that used for epidural analgesia. The rapid onset of inappropriate motor block after a local anaesthetic administered epidurally implies intrathecal spread. Because of claims of greater sensory-motor separation, or because of reduced potency compared with bupivacaine, the efficacy of the new local anaesthetics in intrathecal testing has been questioned. The aim of this study was to establish the feasibility of a test dose for an inadvertent intrathecal catheter using ropivacaine and levobupivacaine, and to establish the dose required. METHODS Sixty women undergoing elective Caesarean section with a combined spinal- epidural technique were enrolled into this prospective, double-blind sequential allocation study. The women were randomized to receive plain levobupivacaine 0.5% or ropivacaine 0.5% intrathecally. The dose was determined according to up-down sequential allocation. The end-point was any evidence of lower limb motor block within 5 min of injection. RESULTS The ED(50) motor block at 5 min was 4.8 mg (95% CI, 4.49, 5.28) for levobupivacaine and 5.9 mg (95% CI, 4.82, 6.98) for ropivacaine (95% CI difference, 0.052, 1.98) (P=0.04). The estimated ED(95) motor block was 5.9 mg (95% CI 5.19, 6.71) for levobupivacaine and 8.3 mg (95% CI, 6.30, 10.44) for ropivacaine. The potency ratio between the two drugs was 0.83 (95% CI, 0.69, 0.99). CONCLUSIONS Both local anaesthetics produce evidence of motor block within 5 min of intrathecal injection and could serve as tests of intrathecal administration. Derived ED(95) values suggest 10 mg doses should be effective, but this study did not measure predictive value. Ropivacaine is less potent for motor block than levobupivacaine by a factor of 0.83 (P<0.04).
Sisvar: a computer statistical analysis system

Sisvar is a statistical analysis system, first released in 1996 although its development began in 1994. The first version was done in the programming language Pascal and compiled with Borland Turbo Pascal 3. Sisvar was developed to achieve some specific goals. The first objective was to obtain software that could be used directly on the statistical experimental course of the Department of Exact Science at the Federal University of Lavras. The second objective was to initiate the development of a genuinely Brazilian free software program that met the demands and peculiarities of research conducted in the country. The third goal was to present statistical analysis software for the Brazilian scientific community that would allow research results to be analyzed efficiently and reliably. All of the initial goals were achieved. Sisvar gained acceptance by the scientific community because it provides reliable, accurate, precise, simple and robust results, and allows users a greater degree of interactivity.