Miracle-dz/UniFAR-FTUs huggingface dataset:
MoodViews: Tools for Blog Mood Analysis

We demonstrate a system for tracking and analyzing moods of bloggers worldwide, as reflected in the largest blogging community, LiveJournal. Our system collects thousands of blog posts every hour, performs various analyses on the posts and presents the results graphically. Exploring the Blogspace From the point of view of information access, the blogspace offers many natural opportunities beyond traditional search facilities, such as trend detection, topic tracking, link tracking, feed generation, etc. But there is more. Many blog authoring environments allow bloggers to tag their entries with highly individual (and personal) features. Users of LiveJournal, currently the largest weblog community, have the option of reporting their mood at the time of the post; users can either select a mood from a predefined list of 132 common moods such as “amused” or “angry,” or enter free-text. A large percentage of LiveJournal users chooses to utilize this option, tagging their postings with a mood. This results in a stream of hundreds of weblog posts tagged with mood information per minute, from hundreds of thousands of different users across the globe. Our focus in this demo is on providing access to the blogspace using moods as the “central” dimension. The type of information needs that we are interested in are best illustrated by questions such as: How do moods develop? How are they related? How do global events impact moods? And: Can global mood swings be traced back to global events? We describe MoodViews, a collection of tools for analyzing, tracking and visualizing moods and mood changes in blogs posted by LiveJournal users.
Uric Acid Induces Trophoblast IL‐1β Production Via the Inflammasome: Implications for the Pathogenesis of Preeclampsia

Citation Mulla MJ, Myrtolli K, Potter J, Boeras C, Kavathas PB, Sfakianaki AK, Tadesse S, Norwitz ER, Guller S, Abrahams VM. Uric acid induces trophoblast IL‐1β production via the inflammasome: implications for the pathogenesis of preeclampsia. Am J Reprod Immunol 2010; 65: 542–548
Calculation of Electron Energy Distribution Functions From Electron Swarm Parameters Using Artificial Neural Network in $\hbox{SF}_{6}$ and Argon

This paper proposes an artificial neural network (ANN) to obtain the electron energy distribution functions (EEDFs) in SF6 and argon from the following: 1) mean energies; 2) the drift velocities; and 3) other related swarm data. In order to obtain the required swarm data, the electron swarm behavior in SF6 and argon is analyzed over the range of the density-reduced electric field strength E/N from 50 to 800 Td from a Boltzmann equation analysis based on the finite difference method under a steady-state Townsend condition. A comparison between the EEDFs calculated by the Boltzmann equation and by ANN for various values of E/N suggests that the proposed ANN yields good agreement of EEDFs with those of the Boltzmann equation solution results.
Isotopic and elemental fractionation of solar wind implanted in the Genesis concentrator target characterized and quantified by noble gases

Abstract– We report concentrations and isotopic compositions of He, Ne, and Ar measured with high spatial resolution along a radial traverse of a silicon carbide (SiC) quadrant of the Genesis mission concentrator target. The Ne isotopic composition maps instrumental fractionation as a function of radial position in the target: the maximum observed isotopic fractionation is approximately 33‰ per mass unit between the center and periphery. The Ne fluence is enhanced by a factor of 43 at the target center and decreases to 5.5 times at the periphery relative to the bulk solar wind fluence. Neon isotopic profiles measured along all four arms of the “gold cross” mount which held the quadrants in the concentrator target demonstrate that the concentrator target was symmetrically irradiated during operation as designed. We used implantation experiments of Ne into SiC and gold to quantify backscatter loss and isotopic fractionation and compared measurements with numerical simulations from the code “stopping and range of ions in matter. ” The 20Ne fluence curve as a function of radial distance on the target may be used to construct concentration factors relative to bulk solar wind for accurate corrections for solar wind fluences of other light elements to be measured in the concentrator target. The Ne isotopic composition as a function of the radial distance in the SiC quadrant provides a correction for the instrumental mass‐dependent isotopic fractionation by the concentrator and can be used to correct measured solar wind oxygen and nitrogen isotopic compositions to obtain bulk solar wind isotopic compositions.
Microcellular Radio Channel Characterization at 60 GHz for 5G Communications

The 60-GHz frequency band is one of the candidates for 5G communications. However, there are not many results that report the radio channel characteristics at outdoor environments for large channel bandwidths using directive steering antennas at the mobile end. We present the results of a wideband measurement campaign using directional steering antennas at the mobile end, an RF frequency bandwidth of 1 GHz, and propagation distances of up to 405 m. We propose to describe the angular power distribution using Gaussian functions. The parameters for the model are empirically determined from the measurements.
Endogenous IL-33 Is Highly Expressed in Mouse Epithelial Barrier Tissues, Lymphoid Organs, Brain, Embryos, and Inflamed Tissues: In Situ Analysis Using a Novel Il-33–LacZ Gene Trap Reporter Strain

IL-33 (previously known as NF from high endothelial venules) is an IL-1 family cytokine that signals through the ST2 receptor and drives cytokine production in mast cells, basophils, eosinophils, invariant NKT and NK cells, Th2 lymphocytes, and type 2 innate immune cells (natural helper cells, nuocytes, and innate helper 2 cells). Little is known about endogenous IL-33; for instance, the cellular sources of IL-33 in mouse tissues have not yet been defined. In this study, we generated an Il-33–LacZ gene trap reporter strain (Il-33Gt/Gt) and used this novel tool to analyze expression of endogenous IL-33 in vivo. We found that the Il-33 promoter exhibits constitutive activity in mouse lymphoid organs, epithelial barrier tissues, brain, and embryos. Immunostaining with anti–IL-33 Abs, using Il-33Gt/Gt (Il-33–deficient) mice as control, revealed that endogenous IL-33 protein is highly expressed in mouse epithelial barrier tissues, including stratified squamous epithelia from vagina and skin, as well as cuboidal epithelium from lung, stomach, and salivary gland. Constitutive expression of IL-33 was not detected in blood vessels, revealing the existence of species-specific differences between humans and mice. Importantly, IL-33 protein was always localized in the nucleus of producing cells with no evidence for cytoplasmic localization. Finally, strong expression of the Il-33–LacZ reporter was also observed in inflamed tissues, in the liver during LPS-induced endotoxin shock, and in the lung alveoli during papain-induced allergic airway inflammation. Together, our findings support the possibility that IL-33 may function as a nuclear alarmin to alert the innate immune system after injury or infection in epithelial barrier tissues.
Netrin-1 dampens pulmonary inflammation during acute lung injury.

RATIONALE Acute lung injury (ALI) is an inflammatory disorder characterized by hypoxemia and diffuse infiltration of neutrophils into the alveolar space. The migration and extravasation of neutrophils is guided through positive guidance cues, such as chemokines. Recent work has identified the neuronal guidance protein netrin-1 to be a negative guidance cue for leukocyte migration and to hold antiinflammatory potential. OBJECTIVES To test the role of pulmonary netrin-1 during ALI. METHODS Pulmonary netrin-1 expression was evaluated during acute inflammation in vitro and in vivo; the netrin-1 promoter was studied using pGL4 luciferase reporter. ALI was induced through LPS inhalation and mechanical ventilation in wild-type, Ntn1(+/-), and A2BAR(-/-) animals. Exogenous netrin-1 was used to evaluate its impact on pulmonary inflammation. MEASUREMENTS AND MAIN RESULTS Wild-type animals demonstrated repression of pulmonary netrin-1 after LPS inhalation. In vitro studies confirmed the repression of netrin-1. Studies in the putative netrin-1 promoter identified a nuclear factor-kappaB-dependent mechanism to be involved in this repression. Ntn1(+/-) animals demonstrated increased inflammatory changes after LPS inhalation compared with Ntn1(+/+) animals. Reconstitution with netrin-1 dampened the infiltration of neutrophils and cytokine production in the alveolar space. This effect was dependent on the adenosine 2b receptor. The importance of netrin-1 for the control of pulmonary inflammation could be corroborated in a model of ventilator-induced lung injury. CONCLUSIONS Pulmonary netrin-1 levels are repressed during ALI. This results in pronounced pulmonary damage, an increased infiltration of neutrophils, and increased pulmonary inflammation. Exogenous netrin-1 significantly dampens the extent of ALI through the adenosine 2B receptor.
Systemic Barriers to Diabetes Management in Primary Care: A Qualitative Analysis of Delaware Physicians

Primary care providers deliver the majority of care for patients with diabetes. This article presents a qualitative analysis of systemic barriers to primary care diabetes management in the small office setting in Delaware. Grounded theory was used to identify key themes of focus group discussions with 25 Delaware physicians. A total of 6 systemic barriers were identified: (1) a persistent orientation toward acute care; (2) an inability to provide proactive, population-based patient management; (3) an inability to provide adequate self-management education; (4) poor integration of payer-driven disease management activities; (5) lack of universally available clinical information; and (6) lack of public health support. The results suggest that significant systemic barriers limit the ability of primary care providers, particularly those in small practices, to effectively manage diabetes in current practice. Future primary care reform should consider how to support providers, particularly those in small practices, to overcome these barriers.
Crossflow microfiltration of cell suspensions.

The application of crossflow microfiltration (CFMF) to processing cell suspensions was proposed in the 1970s. The intervening years have seen the scaling up of the technology to commercial operation and have been a period of intense research interest in the physics of the process. Flaschel et al. (1983) noted that the recovery of biomass (by ultrafiltration) appeared still to be in the phase of development. Later reviews particularly commented on the proprietary nature of much of the useful information required to assess the feasibility of CFMF (Hanisch, 1986; Brown & Kavanagh, 1987), but while the need for further publication of some information is still being stressed (e.g. Heath and Belfort, 1992), detailed reports from biotechnology companies of lab-, pilot- and full-scale applications are now appearing in the literature (Bailey et al., 1990, Sheehan et al, 1990; van Reis et al., 1991). The objective of this review is to describe the major factors influencing CFMF of cell suspensions with particular reference to the recent literature.
Effect of gamma rays and some chemical mutagens on induction of telotrisomics in Hordeum.

Trisomic lines for each of chromosomes 1,3,4,5, and 7 of barley (Hordeum vulgare L.) were subjected to mutagens viz, EMS, DES, HA, FUdR and γ rays in an attempt to induce telocentrics in the extra chromosome. DES and EMS caused a relatively high degree of lethality of trisomies compared with that of disomics. Treatment with HA and γ rays at the time of meiosis caused almost complete sterility. No telotrisomics were recovered from these treatments. Irradiation of trisomic seedlings resulted in the isolation of 11 fragments of which 6 were true telocentrics. The frequency of telocentrics was significantly increased over non-treated material only in stocks of trisomic for chromosomes 1 and 7. All chromosome breaks induced in chromosome 7 were localized at the centromere and the adjacent region of the long arm.
Pressure and strain dependence of the strength of sintered polycrystalline Mg2SiO4 ringwoodite

Differential stresses in a cylindrical rock of polycrystalline Mg2SiO4 ringwoodite were measured at room temperature with pressures up to 10 GPa, axial strains in excess of 20%, and strain rates between 5 × 10−5 and 4 × 10−6 s−1, using the deformation‐DIA coupled with monochromatic X‐rays. The sample exhibited ductile behavior in axial shortening‐lengthening cycles with reproducible hysteresis loops, yielding multiple well‐defined stress‐strain curves. Significant strain hardening was observed beyond the yield point, which occurs at axial strains around 1.5%. Large discrepancies in strength data on ringwoodite reported in previous studies, where no strain information could be obtained, can be reconciled by the strain hardening behavior. Above 8% axial strain, sample stresses reach saturation and the deformation reaches steady state, during which process the ultimate strength increases with hydrostatic pressure but are insensitive to strain rate, suggesting that the sample deforms in low‐temperature plasticity regime.
The effect of fatty acids on the formation of thrombi.

When the sodium salts of certain fatty acids were added to rat blood in vitro, the production of artificial thrombi by a modification of Chandler's method was significantly altered: thrombus-formation time was accelerated greatly and longer thrombi were produced. Straight-chain, saturated fatty acids with sixteen to twenty-six carbon atoms were strongly active. Short-chain fatty acids, C 6 and C 7, were inactive. The four long-chain, unsaturated fatty acids tested, oleic, elaidic, ricinoleic, and arachidonic, were inactive or very nearly so. The activity of a long-chain fatty acid such as stearate, was reduced by the addition of methyl groups.
Intracellular Delivery of Phosphatidylinositol (3,4,5)-Trisphosphate Causes Incorporation of Glucose Transporter 4 into the Plasma Membrane of Muscle and Fat Cells without Increasing Glucose Uptake*

Insulin stimulates glucose uptake into muscle and fat cells by translocating glucose transporter 4 (GLUT4) to the cell surface, with input from phosphatidylinositol (PI) 3-kinase and its downstream effector Akt/protein kinase B. Whether PI 3,4,5-trisphosphate (PI(3,4,5)P3) suffices to produce GLUT4 translocation is unknown. We used two strategies to deliver PI(3,4,5)P3 intracellularly and two insulin-sensitive cell lines to examine Akt activation and GLUT4 translocation. In 3T3-L1 adipocytes, the acetoxymethyl ester of PI(3,4,5)P3 caused GLUT4 migration to the cell periphery and increased the amount of plasma membrane-associated phospho-Akt and GLUT4. Intracellular delivery of PI(3,4,5)P3 using polyamine carriers also induced translocation of myc-tagged GLUT4 to the surface of intact L6 myoblasts, demonstrating membrane insertion of the transporter. GLUT4 translocation caused by carrier-delivered PI(3,4,5)P3 was not reproduced by carrier-PI 4,5-bisphosphate or carrier alone. Like insulin, carrier-mediated delivery of PI(3,4,5)P3 elicited redistribution of perinuclear GLUT4 and Akt phosphorylation at the cell periphery. In contrast to its effect on GLUT4 mobilization, delivered PI(3,4,5)P3 did not increase 2-deoxyglucose uptake in either L6GLUT4myc myoblasts or 3T3-L1 adipocytes. The ability of exogenously delivered PI(3,4,5)P3 to augment plasma membrane GLUT4 content without increasing glucose uptake suggests that input at the level of PI 3-kinase suffices for GLUT4 translocation but is insufficient to stimulate glucose transport.
Perceptions of emotion and age among younger, midlife, and older adults

ABSTRACT Objectives: Older adults report greater emotional well-being than younger persons, yet negative stereotypes about aging are pervasive. Little is known about age group perceptions of emotion in adulthood, particularly for familiar persons. Thus, this project determined perceptions of general affect in familiar younger and older adults. Method: In two studies, participants (Study 1, younger adult n = 123, older adult n = 43; Study 2, younger adult n = 34, midlife adult n = 41, older adult n = 16) provided self-report data about their affect in general, as well as reported on the affect of a familiar younger person (aged 18--34) and a familiar older person (aged 65 or older). Emotion scales assessed high- and low-arousal positive and negative affect. Results: Results suggest a less favorable perception of emotion experiences of older adults compared to younger adults. Specifically, participants of all age groups rated older adults as having lower positive emotions and higher negative emotions than is found in self-report data. Conclusion: Perceptions of emotion in older adulthood reflect stereotypes of negative functioning. Older adult participants were not immune to holding negative views about older adults. Negative perceptions about emotion experiences in later life may be detrimental to the physical and mental health of older adults.
On-Line Monitoring of Solutes in Dialysate Using Absorption of Ultraviolet Radiation: Technique Description

Purpose The aim of this work was to describe a new optical method for monitoring solutes in a spent dialysate using absorption of UV radiation. Method The method utilises UV-absorbance determined in the spent dialysate using a spectrophotometrical set-up. Measurements were performed both on collected dialysate samples and on-line. During on-line monitoring, a spectrophotometer was connected to the fluid outlet of the dialysis machine, with all spent dialysate passing through a specially-designed cuvette for optical single-wavelength measurements. The concentrations of several substances of various molecular sizes, electrical charge, transport mechanism, etc. were determined in the dialysate and in the blood using standard laboratory techniques. The correlation coefficient between UV-absorbance of the spent dialysate and concentration of the substances in the spent dialysate and in the blood was calculated from data based on the collected samples. Results The obtained on-line UV-absorbance curve demonstrates the possibility to follow a single hemodialysis session continuously and to monitor deviations in the dialysator performance using UV-absorbance. The experimental results indicate a very good correlation between UV-absorbance and several small waste solutes removed such as urea, creatinine and uric acid in the spent dialysate and in the blood for every individual treatment at a fixed wavelength of 285 nm. Moreover, a good correlation between the UV-absorbance and substances like potassium, phosphate and β2-microglobulin was obtained. The lowest correlation was achieved for sodium, calcium, glucose, vitamin B12 and albumin. Conclusions A technique for on-line monitoring of solutes in the spent dialysate utilising the UV-absorbance was developed. On-line monitoring during a single hemodialysis session exploiting UV-absorbance represents a possibility to follow a single hemodialysis session continuously and monitor deviations in dialysis efficiency (e.g. changes in blood flow and clearance). The UV-absorbance correlates well to the concentration of several solutes known to accumulate in dialysis patients indicating that the technique can be used to estimate the removal of retained substances.
Settlement of mussels Mytilus galloprovincialis on an exposed rocky shore in Ria de Vigo, NW Spain

The mussel farming industry of the Galician re· gion (NW Spain) requires that 60 to 70% of its seed supply is taken from rocky shore areas. However there are almost no quantitative data for a recruitme nt and settlement pattern. In the Ria de Vigo a continuous settlement throughout the year with a major settlement season fr om May to September was fo und, reflecting the presence of spawning mussels through· out the year and the occurrence of a maJor spawning period during the spring. The observed settlement pattern indicates the direct settlement of larvae from the plankton onto the adult beds and an immigration of mussels previously settled on other substrates. This pattern could be a response to the ecological and environmental conditions that occurred on the Galician rocky shores, but could also be a differential charac· teristic between Mytilus edulis and M. galloprovincialis.
COMPARATIVE ANALYSIS OF A HYBRID DE ALGORITHM WITH THE VNS ALGORITHM AND ITS VARIATION SVNS TO SOLVE A REAL-WORLD FREQUENCY ASSIGNMENT PROBLEM

The Frequency Assignment is a very important task in the planning of the GSM networks, and it still continues to be a critical task for current (and future) mobile communication operators. In this work, we compare a hybrid Differential Evolution algorithm with the Variable Neighbourhood Search algorithm and also its variant Skewed Variable Neighbourhood Search to solve a real-world Frequency Assignment problem (FAP) in GSM Networks. The results that are shown use accurate interference information. That information was also adopted by other researchers and it represents a real GSM network, granting, therefore, an really important applicability. Furthermore, we have analyzed and compared our approach with other algorithms proposed so far to this problem. Hence, our approach using the SVNS algorithm has proven to be efficient in solving this problem, and permitted us to obtain good results. In fact, with this work we have contributed to the FAP problem with an additional comparison between approaches using metaheuristics based on trajectory (VNS and SVNS) and others based on population (DE).
Effects of acute administration of acylated and unacylated ghrelin on glucose and insulin concentrations in morbidly obese subjects without overt diabetes.

OBJECTIVE To investigate the effects of unacylated ghrelin (UAG) and co-administration of acylated ghrelin (AG) and UAG in morbid obesity, a condition characterized by insulin resistance and low GH levels. DESIGN AND METHOD Eight morbidly obese non-diabetic subjects were treated with either UAG 200 microg, UAG 100 microg in combination with AG 100 microg (Comb) or placebo in three episodes of 4 consecutive days in a double-blind randomized crossover design. Study medication was administered as daily single i.v. bolus injections at 0900 h after an overnight fast. At 1000 h, a standardized meal was served. Glucose, insulin, GH, free fatty acids (FFA) and ghrelin were measured up to 4 h after administration. RESULTS Insulin concentrations significantly decreased after acute administration of Comb only, reaching a minimum at 20 min: 58.2 + or - 3.9% of baseline versus 88.7 + or - 7.2 and 92.7 + or - 2.6% after administration of placebo and UAG respectively (P<0.01). After 1 h, insulin concentration had returned to baseline. Glucose concentrations did not change after Comb. However, UAG administration alone did not change glucose, insulin, FFA or GH levels. CONCLUSION Co-administration of AG and UAG as a single i.v. bolus injection causes a significant decrease in insulin concentration in non-diabetic subjects suffering from morbid obesity. Since glucose concentration did not change in the first hour after Comb administration, our data suggest a strong improvement in insulin sensitivity. These findings warrant studies in which UAG with or without AG is administered for a longer period of time. Administration of a single bolus injection of UAG did not influence glucose and insulin metabolism.