Miracle-dz/UniFAR-FTUs huggingface dataset:
Borderline Personality Disorder, Bulimia Nervosa, Antisocial Personality Disorder, ADHD, Substance Use: Common Threads, Common Treatment Needs, and the Nature of Impulsivity.

Our intent in offering this contribution is to share with independent practitioners recent advances in clinical psychology research that shed light on the nature of a wide range of disorders related to impulsivity, as well as information on treatment decisions to be made with individuals suffering from such disorders. We come from academic training programs designed to integrate clinical research and clinical practice (the last author is a member of division 42). We hope that the findings we describe prove useful to the many practitioners who encounter some form of problems related to impulsive behavior in their work.
Comparison of four neural net learning methods for dynamic system identification

Four types of neural net learning rules are discussed for dynamic system identification. It is shown that the feedforward network (FFN) pattern learning rule is a first-order approximation of the FFN-batch learning rule. As a result, pattern learning is valid for nonlinear activation networks provided the learning rate is small. For recurrent types of networks (RecNs), RecN-pattern learning is different from RecN-batch learning. However, the difference can be controlled by using small learning rates. While RecN-batch learning is strict in a mathematical sense, RecN-pattern learning is simple to implement and can be implemented in a real-time manner. Simulation results agree very well with the theorems derived. It is shown by simulation that for system identification problems, recurrent networks are less sensitive to noise.
DART: delay and routability driven technology mapping for LUT based FPGAs

A two-phased approach for routability directed delay-optimal mapping of LUT based FPGAs is presented based on the results of stochastic routability analysis. First, delay-optimal mapping is performed which simultaneously minimizes area and delay. Then, the mapped circuits are restructured to alleviate the potential routing congestions. Experimental results indicate that the first phase creates designs which require 17% fewer levels and 40% fewer LUTs than MIS-pga (delay), 11% fewer levels and 37% fewer LUTs than FlowMap-r, and 5% fewer levels and 39% fewer LUTs than TechMap-D. The success of the second phase is confirmed by running a vendor's layout tool APR. It is observed that they are more routable and have less final delays than those produced by other mappers if they are placed and routed.
Joint effects of gray matter atrophy and altered functional connectivity on cognitive deficits in amnestic mild cognitive impairment patients

Background Gray matter (GM) atrophy and disrupted intrinsic functional connectivity (IFC) are often present in patients with amnestic mild cognitive impairment (aMCI), which shows high risk of developing into Alzheimer's disease. Little is known, however, about the relationship between GM atrophy and altered IFC, and whether they are related to cognitive decline. Method A total of 30 aMCI and 26 cognitively normal (CN) subjects were recruited for this study. Optimized voxel-based morphometric and resting-state functional connectivity magnetic resonance imaging approaches were performed to measure the GM volumes (GMVs) and atrophy-related IFC, respectively. Multivariate linear regression analysis was used to examine the effects of GM atrophy and IFC on cognitive performance across subjects, after controlling for the effects of age, education, gender and group. Results Compared with CN subjects, aMCI subjects showed significantly reduced GMVs and decreased IFC in the frontal-parietal and medial temporal lobe systems. Multivariate regression analysis further demonstrated that the GMVs and decreased IFC simultaneously affected the cognitive function. Specifically, GMVs were positively correlated with cognitive performances, including global cognition and episodic memory, and showed a strong trend in correlation between GMVs and non-episodic memory, whilst IFC was positively correlated with the above three cognitive measures, across all subjects. In addition, significant correlation was found between GMVs and altered IFC strength across all subjects. Conclusions Our findings demonstrated that GMVs and IFC jointly contribute to cognitive performance, and combining quantitative information about GMVs and the strength of functional connectivity may serve as an indicator of cognitive deficits in non-demented elderly.
Short- and Medium-Term Increase of CA125 in Peritoneal Effluent using a Neutral-pH Solution

♦ Objective To investigate the effects of an alternative peritoneal dialysis (PD) solution composed of a lactate/bicarbonate (Lac/Bic) mixture (35/2 mmol/L), pH 7.0, on the appearance of cancer antigen 125 (CA125) in the peritoneal effluent. ♦ Methods Eight stable PD patients received a conventional solution containing 35 mmol/L lactate (Lac) for 11.9 ± 9.2 months, and then changed to Lac/Bic for 3.1 ± 0.7 months. Each patient acted as his/her own control. ♦ Results We studied 4 males and 4 females with a mean age of 57.4 ± 16.8 years. Higher concentrations (U/mL) (p < 0.005) and appearance rates (AR) (U/min) (p < 0.05) of CA125 in the dialysate were observed with Lac/Bic than with Lac, during the sampling times of the peritoneal equilibration test (10, 120, and 240 minutes) and in the overnight effluent: CA125 5.7 versus 0.6, 18.9 versus 1.9, 29.7 versus 3.7, and 43.2 versus 5.5 U/mL; and AR 1177 versus 125, 354 versus 36,297 versus 37, and 194 versus 26 U/min, respectively. Mean CA125 content in the 24-hour dialysate was 34.2 U/min (baseline) and 30.9 U/min (11.9 months) with Lac, and 207.9 U/min and 185 U/min after 1.6 and 3.1 months with Lac/Bic (p = 0.009). The intraperitoneal pH was more physiological during the dwell with the Lac/Bic solution. ♦ Conclusions The CA125 levels in the peritoneal effluent with Lac/Bic are an effect of the solution's neutral pH, as other factors of the prescription were constant. The Lac/Bic solution is more biocompatible than Lac, reflecting short- and medium-term changes in the mesothelial cells, whose clinical significance has not yet been determined.
Targeting anti‐beta‐1‐adrenergic receptor antibodies for dilated cardiomyopathy

Anti‐beta‐1‐adrenergic receptor antibodies (anti‐β1AR Abs) have long been implicated in the pathogenesis of dilated cardiomyopathy (DCM). It is believed that these autoantibodies bind to and constitutively stimulate the β1AR to promote pathological cardiac remodelling and β1AR desensitization and downregulation. The prevalence of anti‐β1AR Abs in patients with DCM ranges from 26% to 60%, and the presence of these autoantibodies correlates with a poor prognosis. Several small studies have shown improvements in functional status, haemodynamics, and biomarkers of heart failure upon removal or neutralization of these antibodies from the sera of affected patients. Traditionally, removal of anti‐β1AR Abs required immunoadsorption therapy with apheresis columns directed against human immunoglobulins (Igs) and subsequent i.v. Ig infusion, thereby essentially performing a plasma exchange transfusion. However, recent advances have allowed the development of small peptides and nucleotide sequences that specifically target and neutralize anti‐β1AR Abs, providing a hopeful avenue for future drug development to treat DCM. Herein, we briefly review the clinical literature of therapy directed against anti‐β1AR Abs and highlight the opportunity for further research and development in this area.
Corrections to AASLD guidelines on chronic hepatitis B

We would appreciate if corrections to Tables 2 and 10 in Lok and McMahon (HEPATOLOGY 2007;45:507-539) and a cautionary note on the use of entecavir in patients with hepatitis B virus (HBV)/human immunodeficiency virus (HIV) coinfection not simultaneously receiving highly active antiretroviral therapy (HAART) be brought to the attention of our readers. We deeply regret that Table 2 regarding who should be screened for HBV infection had an error: in the first bullet point, “South Asia” should be replaced with “Asia”. Below is a corrected version of Table 2.
Determination of recombination coefficients for nanocrystalline silicon embedded in hydrogenated amorphous silicon

The spectroscopic pump-probe reflectance method was used to investigate recombination dynamics in samples of nano crystalline silicon embedded in a matrix of hydrogenated amorphous silicon. We found that the dynamics can be described by a rate equation including linear and quadratic terms corresponding to recombination processes associated with impurities and impurityassisted Auger ionisation, respectively. We determined the values of the recombination coefficients using the initial concentrations method. We report the coefficients of 1.5×1011 sec−1 and 1.1 × 10−10 cm3sec−1 for the impurity-assisted recombination and Auger ionization, respectively. © 2015 Optical Society of America
D-amino acid oxidase inhibitors as a novel class of drugs for schizophrenia therapy.

Over the years, accumulating evidence has indicated that D-serine represents the endogenous ligand for the glycine modulatory binding site on the NR1 subunit of N-methyl-D-aspartate receptors in various brain areas. Cellular concentrations of D-serine are regulated by synthesis due to the enzyme serine racemase (isomerization reaction) and by degradation due to the same enzyme(elimination reaction) as well as by the FAD-containing flavoenzyme D-amino acid oxidase (DAAO, oxidative deamination reaction). Several findings have linked low levels of D-serine to schizophrenia: D-serine concentrations in serum and cerebrospinal fluid have been reported to be decreased in schizophrenia patients while human DAAO activity and expression are increased; oral administration of D-serine improved positive, negative, and cognitive symptoms of schizophrenia as add-on therapy to typical and atypical antipsychotics.This evidence indicates that increasing NMDA receptor function, perhaps by inhibiting DAAO-induced degradation of D-serine may alleviate symptoms in schizophrenic patients. Furthermore, it has been suggested that co-administration of D-serine with a human DAAO inhibitor may be a more effective means of increasing D-serine levels in the brain. Here, we present an overview of the current knowledge of the structure-function relationships in human DAAO and of the compounds recently developed to inhibit its activity (specifically the ones recently exploited for schizophrenia treatment).
GPS tracking data of Western marsh harriers breeding in Belgium and the Netherlands

Abstract In this data paper three datasets are described containing GPS tracking and acceleration data of Western marsh harriers (Circus aeruginosus) breeding in Belgium and the Netherlands. The Western marsh harrier is included as a threatened bird species in Annex I of the European Bird Directive due to the steep decline in population densities. In order to collect data of habitat use and migration behaviour, Western marsh harriers were equipped with light-weight solar powered GPS trackers developed by the Institute for Biodiversity and Ecosystem Dynamics (IBED) at the University of Amsterdam (University of Amsterdam Bird Tracking System, UvA-BiTS). These trackers automatically collect and store data on the bird’s activity and 3D position in time and transmit these data to ground stations. The datasets were collected by the Research Institute for Nature and Forest (INBO) and the Dutch Montagu’s Harrier Foundation. Tracked Western marsh harriers were breeding in the northeast of the Dutch province of Groningen and on the opposite side of the river Ems in Germany (H_GRONINGEN), in the region of Waterland-Oudeman near the Belgian-Dutch border (MH_WATERLAND), and at the left bank of the Scheldt estuary, close to the Belgian-Dutch border and north of the city of Antwerp (MH_ANTWERPEN). Most individuals remained within 10 km from their nesting sites during the breeding season and wintered in West Africa. H_GRONINGEN contains 987,493 GPS fixes and 3,853,859 acceleration records of four individuals since 2012. MH_WATERLAND contains 377,910 GPS fixes of seven individuals. Sampling in this region began in 2013. Three more Western marsh harriers were tagged in the Scheldt estuary near Antwerp more recently in 2018 (one individual) and 2019 (two individuals) for the MH_ANTWERPEN study, which contains 47,917 GPS fixes and 227,746 acceleration records. The three Western marsh harrier datasets were published as separate studies in Movebank (https://www.movebank.org) and archived as data packages in Zenodo (https://www.zenodo.org) to ensure long-term preservation and versioning of the data.
Audiovisual speech processing in visual speech noise

When the talker’s face (visual speech) can be seen, speech perception is both facilitated (for congruent visual speech) and interfered with (for incongruent visual speech). The current study investigated whether the degree of these visual speech effects was affected by the presence of an additional irrelevant talking face. In the experiment, auditory speech targets (vCv syllables) were presented in noise for subsequent speech identification. Participants were presented with the full display or upper-half (control) display of a talker’s face uttering single syllables either in central vision (Exp 1) or in the visual periphery (Exp 2). In addition, another talker was presented (silently uttering a sentence) either in the periphery (Exp 1) or in central vision (Exp 2). Participants’ eye-movements were monitored to ensure that participants always fixated centrally. Congruent AV speech facilitation and incongruent McGurk effects were tested by comparing percent correct syllable identification for full face visual speech stimuli compared to upper-face only conditions. The results showed more accurate identification for congruent stimuli and less accurate responses for incongruent ones (full face condition vs. the upper-half face control). The magnitude of the McGurk effect was greater when the face articulating the syllable was presented in central vision (with visual speech noise in the periphery) than when it was presented in the periphery (with central visual speech noise). The size of the congruent AV speech effect, however, did not differ as a function of central or peripheral presentation.
Storage Lipid Synthesis Is Non-essential in Yeast*

Steryl esters and triacylglycerol (TAG) are the main storage lipids in eukaryotic cells. In the yeastSaccharomyces cerevisiae, these storage lipids accumulate during stationary growth phase within organelles known as lipid bodies. We have used single and multiple gene disruptions to study storage lipid synthesis in yeast. Four genes, ARE1, ARE2, DGA1, and LRO1, were found to contribute to TAG synthesis. The most significant contribution is made byDGA1, which encodes a novel acyl-CoA:diacylglycerol acyltransferase. Two of the genes, ARE1 andARE2, are also involved in steryl ester synthesis. A yeast strain that lacks all four genes is viable and has no apparent growth defects under standard conditions. The strain is devoid of both TAG and steryl esters, and fluorescence microscopy revealed that it also lacks lipid bodies. We conclude that neither storage lipids nor lipid bodies are essential for growth in yeast.
Assessment of percutaneous coronary intervention on regional and global left ventricular function in patients with chronic total occlusions.

BACKGROUND The improvement of regional and global ventricular function following percutaneous coronary intervention (PCI) with reperfusion of the artery supplying the infarct area in acute myocardial infarction is well-described. However, little is known of the potential effects of late recanalization of chronic coronary artery occlusion on left ventricular function. OBJECTIVE To determine whether PCI improves regional and global left ventricular function in patients with chronic coronary artery occlusions. PATIENTS AND METHODS Thirty-five patients having at least one coronary artery occluded for six weeks or longer were included in the present prospective study. Exercise thallium-201 myocardial perfusion scintigraphy, multiple-gated acquisition ventriculography and two-dimensional echocardiography were performed in 19 patients (16 men; mean age of 58+/-5 years) who underwent a successful PCI to assess both regional and global left ventricular function before and six weeks following the procedure. RESULTS The mean ejection fractions before and after reperfusion were 51+/-7% and 58+/-6% using Simpson's method (P<0.001) by echocardiography, and 45+/-1% and 53+/-1% (P=0.01) by multiple-gated acquisition ventriculography, respectively. The echocardiographic wall motion score was 24+/-9 before and 15+/-6 after PCI (P<0.001). The exercise perfusion score (21+/-1 and 14+/-1 [P=0.01]), rest perfusion score (15+/-1 and 12+/-1 [P=0.02]) and reinjection perfusion score (14+/-1 and 11.1+/-1 [P=0.07]) also improved after PCI. The presence of angina was strongly associated with an improvement in left ventricular function and wall motion score (P<0.01). CONCLUSIONS PCI significantly improved the regional and global left ventricular function in patients with chronic total coronary occlusion. This procedure may provide symptom benefits in selected patients.
Wide Variation and Overprescription of Opioids After Elective Surgery

Objective: We aimed to identify opioid prescribing practices across surgical specialties and institutions. Background: In an effort to minimize the contribution of prescription narcotics to the nationwide opioid epidemic, reductions in postoperative opioid prescribing have been proposed. It has been suggested that a maximum of 7 days, or 200 mg oral morphine equivalents (OME), should be prescribed at discharge in opioid-naïve patients. Methods: Adults undergoing 25 common elective procedures from 2013 to 2015 were identified from American College of Surgeons National Surgical Quality Improvement Program data from 3 academic centers in Minnesota, Arizona, and Florida. Opioids prescribed at discharge were abstracted from pharmacy data and converted into OME. Wilcoxon Rank-Sum and Kruskal-Wallis tests assessed variations. Results: Of 7651 patients, 93.9% received opioid prescriptions at discharge. Of 7181 patients who received opioid prescriptions, a median of 375 OME (interquartile range 225–750) were prescribed. Median OME varied by sex (375 men vs 390 women, P = 0.002) and increased with age (375 age 18–39 to 425 age 80+, P < 0.001). Patients with obesity and patients with non-cancer diagnoses received more opioids (both P < 0.001). Subset analysis of the 5756 (75.2%) opioid-naïve patients showed the majority received >200 OME (80.9%). Significant variations in opioid prescribing practices were seen within each procedure and between the 3 medical centers. Conclusions: The majority of patients were overprescribed opioids. Significant prescribing variation exists that was not explained by patient factors. These data will guide practices to optimize opioid prescribing after surgery.
Low-Level Laser Therapy versus Four Layers Compression Technique in the Treatment of Venous Ulcers

Objective: The aim of the study is to evaluate the effect of low-level laser therapy in comparison to compression bandage therapy in the treatment of venous ulcers. Subjects & Methods: This study was carried out in the period from March 2013 to March 2014. The study included 40 adult patients with a diagnosis of venous ulcer classified as C6 according to the clinical classification of CEAP classification. The patients were divided into 2 groups: the first one included 20 patients treated by low-level laser therapy at the Rheumatology and Rehabilitation department, and the second group included 20 patients in whom we use four layers compression bandaging at the vascular surgery department. Results: 32 ulcers were treated in group I and 35 ulcers were treated in group II. The patients of group I were 7 (35%) females and 13 (65%) males, their age range were (24 - 56) years. The patients of group II were 11 (55%) males and 9 (45%) females; their age ranges were (32 - 50) years. Measurements of the ulcers size by (cm2) were taken at the beginning of therapy, at 1 month, at 2 months and at 3 months later on. The calculation of the area of the ulcer was done by using the graph papers to document the ulcer’s perpendicular linear dimensions. According to the size of the ulcer, some ulcers heal within 1 month (15.6%) ulcers in group I, and (28.5%) in group II. Some ulcers heal within 2 months (28%) in group I, and (37%) in group II. The remaining ulcers heal within 3 months or more which are (56%) ulcers in group I, and (34.2%) ulcers in group II. The recurrence rate of chronic venous leg ulcer in compression bandage technique used in group II was the least one as the total number of recurrent cases were 5 (25%), followed by laser therapy used in group I. Conclusion: There was no significant efficacy of the low-level laser therapy over the four layers compression technique in the management of chronic venous ulcers.
HIV infection dynamics in rural Andhra Pradesh south India: A sexual-network analysis exploratory study

Abstract The southern state of Andhra Pradesh (AP) has one of the highest rates of HIV-1 infection in India. Estimates of HIV infection in rural areas have begun to approximate the urban. Methods of HIV transmission in rural India are poorly understood. We examined risk factors for HIV transmission in a group of rural villages in AP through the use of a sexual-network analysis survey—the Indian Health and Family Life Survey (IHFLS). The study sample included 20 HIV-positive and 40 HIV-negative matched controls randomly selected from a population-based, voluntary counselling and testing program in rural AP. HIV-1 status was confirmed by Western Blot. The 405-item IHFLS is based upon the National Health and Life Survey which has been validated in the US and China. The sample mean age was 37 years and 22% were of a tribal caste. Among female respondents, none were commercial sex workers (CSWs) and there were no significant social or behavioral associations with HIV infection. Among male respondents, ever having bought sex and having more than one lifetime partner were found to be significantly associated with HIV infection (p=0.002 and p=0.017). Amongst sub-populations, all men who had sex with men (MSM) were married. Tribals were more likely to report a concurrent sexual relationship (p=0.04). All high-risk men, including MSM, men who buy sex and men with multiple lifetime female partners did not use condoms. Public health interventions aimed at reducing HIV transmission in rural AP should consider targeting sub-populations of men who engage in covert MSM or CSW, high-risk tribal caste members and at-risk wives.