Miracle-dz/UniFAR-FTUs huggingface dataset:
Change in intraocular pressure during long-term use of loteprednol etabonate.

PURPOSE Loteprednol etabonate is a novel site-active corticosteroid synthesized through structural modifications of prednisolone-related compounds so that it will undergo a predictable transformation to an inactive metabolite. In double-masked studies, loteprednol etabonate was effective in the treatment of giant papillary conjunctivitis, seasonal allergic conjunctivitis, postoperative inflammation, and uveitis. The objective of this analysis was to determine the incidence of clinically significant elevations in intraocular pressure (IOP) with long-term use of loteprednol etabonate. PATIENTS AND METHODS All subjects (healthy volunteers or patients with inflammation or allergy) in all sponsored loteprednol etabonate studies in the United States were evaluated. A clinically significant elevation in IOP was defined as > or = 10 mmHg at any visit, and long-term use was defined as > or = 28 days. Of the 2,210 subjects, 1,648 were treated for 28 days or longer with loteprednol etabonate (0.2% or 0.5%), prednisolone acetate 1%, or vehicle. RESULTS IOP elevation > or = 10 mmHg occurred in 1.7% (15/901) of patients taking long-term loteprednol etabonate, 0.5% (3/583) of those taking vehicle, and 6.7% (11/164) of those taking prednisolone acetate. Excluding patients who wore contact lenses, the incidence was 0.6% (4/624), 1.0% (3/304), and 6.7% (11/164) for loteprednol etabonate, vehicle, and prednisolone acetate, respectively. The incidence of IOP elevations with 0.2% loteprednol etabonate was 0.8% (1/133), similar to that for vehicle (0.7%, 1/135). CONCLUSION The results of this analysis in a large population of subjects undergoing long-term therapy and of a previously published controlled, double-masked study in corticosteroid responders suggest that loteprednol etabonate has less propensity to cause clinically significant elevations in IOP than prednisolone acetate.
The development of a valid and reliable scale for rating anxiety in dementia (RAID)

A rating scale to measure anxiety in dementia sufferers was developed and evaluated in a sample of 51 inpatients and 32 day-hospital patients. Anxiety scores were not related to sex, age, accommodation or DSM-IV diagnosis of the type of dementia. However, both subjects with physical illnesses and subjects with insight into their memory problems had significantly higher anxiety scores.The kappa values for inter-rater reliability ranged from 0.51 to 1 and for test-retest reliability from 0.53 to 1, which indicates moderate to good reliability.The overall agreement on individual items ranged from 82-100% (inter-rater) and 84-100% (test-retest). The professionals working in the care of the elderly and carer groups felt that the scale was comprehensive and all the items in the scale were important, thereby confirming that it has good content validity. The scale significantly correlated with other anxiety scales and also with independent ratings both by a consultant psychiatrist and also nursing staff, indicatin.
Financial Health, Exports and Firm Survival: Evidence from UK and French Firms

type="main" xml:id="ecca12080-abs-0001"> We use firm-level data for the UK and France to assess the role of exporting in the link between financial health and firm survival. We examine whether firms at different stages of export activity (starters, exiters, continuers, switchers) react differently to changes in financial variables. In general, export starters and exiters experience much stronger adverse effects of financial constraints for their survival prospects. By contrast, the exit probability of continuous exporters and export switchers is less negatively affected by financial characteristics. These relationships between exporting, finance and survival are broadly similar in the UK and French samples.
Time-Zero Renal Biopsy in Living Kidney Transplantation: A Valuable Opportunity to Correlate Predonation Clinical Data With Histological Abnormalities

Background. Living kidney donation is increasing as a partial solution for wait-listed patients. Despite properly followed guideline criteria for donor selection, current reports identify unsuspected renal pathology at preimplantation or time-zero biopsy (T0-RBx). Methods. T0-RBx was evaluated for following: interstitial fibrosis (IF), tubular atrophy (TA), arteriolar hyalinosis (AH), mesangial increase (MI), and glomerulosclerosis (GS). Predonation data were demography, body weight, body mass index (BMI), systolic/diastolic blood pressure (BP), serum creatinine (SCr), estimated glomerular filtration rate (eGFR), and proteinuria. Results. Two hundred nineteen T0-RBx were analyzed. Of these 54.4% had abnormal findings, namely, IF in 29%, TA in 13%, MI in 12%, AH in 10%, and GS in 10%. Mean clinical data were as follows: age 35.4±10 years, weight 66.27±10.14 kg, BMI 25.53±2.99, systolic BP 115±9 mm Hg, diastolic BP 74±7 mm Hg, SCr 0.91±0.25 mg/dL, eGFR 96±16.65 mL/min, and proteinuria 70.25±62.8 mg/24 hr. A total of 56.7% were women. IF correlated to age (r=0.22, P=0.001) and SCr (r=0.19, P=0.005); TA to diastolic BP (r=0.15, P=0.03) and proteinuria (r=0.20, P=0.009); AH to SCr (r=0.15, P=0.02) and eGFR (r=−0.16, P=0.018); MI to BMI (r=0.13, P=0.047). Multivariate analysis failed to sustain the significant associations found on bivariate analysis, most likely due to a low event/parameter relation and sample size. Conclusions. A significant correlation was established between T0-RBx findings and clinical predonation parameters. Whether these mild histologic findings at the time of kidney donation represent a higher risk for the remaining kidney ought to be evaluated during follow-up. In an era, when living kidney donation is increasing, we advise closer donor surveillance to modify risk factors that participate in kidney damage progression.
Self-Vth-Cancellation High-Efficiency CMOS Rectifier Circuit for UHF RFIDs

A high-efficiency CMOS rectifier circuit for UHF RFID applications was developed. The rectifier utilizes a self-Vth-cancellation (SVC) scheme in which the threshold voltage of MOSFETs is cancelled by applying gate bias voltage generated from the output voltage of the rectifier itself. A very simple circuit configuration and zero power dissipation characteristics in biasing enable excellent power conversion efficiency (PCE), especially under small RF input power conditions. At higher RF input power conditions, the PCE of the rectifier automatically decreases. This is the built-in self-power-regulation function. The proposed SVC CMOS rectifier was fabricated with a 0.35-µm CMOS process and the measured performance was compared with those of conventional nMOS, pMOS, and CMOS rectifiers and other types of Vth cancellation rectifiers as well. The SVC CMOS rectifier achieves 32% of PCE at the -10dBm RF input power condition. This PCE is larger than rectifiers reported to date under this condition.
Limited predictive value of an acute test with subcutaneous octreotide for long-term IGF-I normalization with Sandostatin LAR in acromegaly.

OBJECTIVES To study whether the growth hormone (GH) response after the subcutaneous administration 50 microg of octreotide (acute octreotide test) has any predictive value for long-term IGF-I normalization with Sandostatin LAR. DESIGN Twenty four therapy-naive patients with active acromegaly were studied. RESULTS > 75% GH decrease in the acute octreotide test predicted long-term IGF-I normalization with Sandostatin LAR in 8/11 (73%) of patients. 3/13 (23%) patients with < 75% GH decrease in the acute octreotide test were long-term biochemically controlled with Sandostatin LAR. Using the > 75% GH reduction criterion, the sensitivity and specificity of this test for predicting long-term normalization of serum IGF-I with Sandostatin LAR treatment were 73% and 77%, respectively (positive and negative predictive values: 73% and 77%, respectively). 6/8 (75%) patients with GH suppression to levels < 1.1 microg/l and 9/16 (56%) patients with GH suppression to levels < 2 microg/l in the acute octreotide test showed normalization of serum IGF-I with long-term Sandostatin LAR treatment. The sensitivity and specificity of GH suppression < 1.1 microg/l for predicting of the long-term normalization of serum IGF-I with Sandostatin LAR therapy were 55% and 85%, respectively (positive and negative predictive values: 75% and 69%, respectively). The sensitivity and specificity of GH suppression < 2 microg/l for predicting of the long-term normalization of serum IGF-I with Sandostatin LAR therapy were 82% and 46%, respectively (positive and negative predictive values: 56% and 75%, respectively). CONCLUSION The acute octreotide is not recommended for clinical decision making with regard to long-term treatment using the long-acting somatostatin analog Sandostatin LAR in acromegaly.
Functional characterization of tektin-1 in motile cilia and evidence for TEKT1 as a new candidate gene for motile ciliopathies

A child presenting with Mainzer-Saldino syndrome (MZSDS), characterized by renal, retinal and skeletal involvements, was also diagnosed with lung infections and airway ciliary dyskinesia. These manifestations suggested dysfunction of both primary and motile cilia, respectively. Targeted exome sequencing identified biallelic mutations in WDR19, encoding an IFT-A subunit previously associated with MZSDS-related chondrodysplasia, Jeune asphyxiating thoracic dysplasia and cranioectodermal dysplasia, linked to primary cilia dysfunction, and in TEKT1 which encodes tektin-1 an uncharacterized member of the tektin family, mutations of which may cause ciliary dyskinesia. Tektin-1 localizes at the centrosome in cycling cells, at basal bodies of both primary and motile cilia and to the axoneme of motile cilia in airway cells. The identified mutations impaired these localizations. In addition, airway cells from the affected individual showed severe motility defects without major ultrastructural changes. Knockdown of tekt1 in zebrafish resulted in phenotypes consistent with a function for tektin-1 in ciliary motility, which was confirmed by live imaging. Finally, experiments in the zebrafish also revealed a synergistic effect of tekt1 and wdr19. Altogether, our data show genetic interactions between WDR19 and TEKT1 likely contributing to the overall clinical phenotype observed in the affected individual and provide strong evidence for TEKT1 as a new candidate gene for primary ciliary dyskinesia.
Blink reflex abnormalities in diabetes mellitus

Damage of the peripheral nervous system is particularly frequent in diabetes mellitus (DM), but somatic cranial neuropathies usually presenting as mononeuropathies are rare. Oculomotor and facial nerves are among the most commonly affected, whereas the Vth, IXth and Xth cranial nerves are less often affected. While existing neurophysiological tests in the subclinical diagnosis of damage to the peripheral nerve in diabetic patients have advanced, the same does not hold true for the subclinical diagnosis of the central nervous system (CNS). Electrophysiological studies such as the blink reflex was shown to be an effective method for revealing subclinical involvement of cranial nerves in generalised neuropathies.
Mind and Body in Late Plato

Abstract In this paper I re-examine the status of the mind-body relation in several of Plato’s late dialogues. A range of views has been attributed to Plato here. For example, it has been thought that Plato is a substance dualist, for whom the mind can exist independently of the body; or an attribute dualist, who has left behind the strong dualistic commitments of the Phaedo by allowing that the mind may be the subject of spatial movements. But even in cases where a classification of Plato as a holder of a particular ontology of the mind has been left undefined, it has been a shared assumption that in the late dialogues the mind itself must be immaterial. I take issue with these various views and show that none of them is necessitated by the text. In the first place, I argue there is strong evidence against the view that Plato should, in his late period, be committed not only to substance dualism, but also to attribute dualism. Furthermore, it is possible that Plato may have allowed that the mind itself be a three-dimensional corporeal entity (in a way that sets up a precedent for later Stoic developments). But even if this is not the only possible reading of the text, it is shown how at any rate the mind must be seen in late Plato as the principle of organization of a body and ontologically inseparable from it. Despite prima facie affinities with Aristotle here, we shall see a Plato emerge for whom the mind (without exception) and the body cannot exist without one another – a thesis more radical than that of Aristotle’s. To bring out the provocative nature of this suggestion, I start, in section I, by laying out the state of the question and compare what I shall argue is the late Platonic view with standard interpretations of his previous work, stressing the historical force that I expect this thesis to have. Afterwards, in three respective sections, I proceed to pay heed to relevant passages in the Timaeus, Philebus and Laws in order to establish the main point of this paper. Finally, in section V, I consider the challenge apparently introduced against my thesis by Plato’s occasional talk of immortality and eschatology in those dialogues, and argue instead that many of those passages add further strength to the view defended in this essay.
Indian study sparks debate on the use of placebo in psychiatry trials

Indian doctors have questioned the ethics of a study in which patients with severe mental illness were given placebo for up to three weeks in eight hospitals across India. In the double blind, placebo controlled study, which was carried out in 2001, 144 patients received placebo as part of an effort to evaluate the efficacy of the antipsychotic drug risperidone in patients with acute mania. Hospital ethics committees had approved the study, which was supported by Johnson & Johnson, and doctors had obtained written informed consent from the patients or their legal representatives. The company and the principal investigators of the study have said that only patients whose symptoms were poorly controlled with standard treatment were admitted to the study. The study found that patients who were given risperidone showed significantly greater improvements than the patients in the placebo group ( British Journal of Psychiatry 2005;187: 229-34). “The study has helped establish the safety and efficacy of risperidone over and above placebo,” said Sumant …
Myocardial infarction in young versus older adults: clinical characteristics and angiographic features.

BACKGROUND Coronary artery disease is now frequently encountered in young adult population. However, being a relatively uncommon entity, not many studies are available in this regard. Therefore, the present study was designed to evaluate the clinical characteristics and angiographic features of patients less than 40 years of age with a history of myocardial infarction and compare them to patients older than 40 years. METHODS A total of 281 patients who underwent coronary angiography from April, 2009 to December, 2009, were included in this study. The patients were divided into two groups on the basis of age. Group A included patients 40 years of age or younger. Group B included patients older than 40 years. Both the groups were compared with respect to gender, hypertension, diabetes mellitus and extent and severity of coronary artery disease as assessed on coronary angiography. RESULTS Of the total 281 patients, 45 (16%) were < or =40 years old (Group-A) and 236 (84%) were older than 40 years (Group-B). There was no significant difference between the two groups with respect to the risk factors like gender, hypertension and diabetes mellitus. On coronary angiography, the two groups neither differed in the number of totally occluded vessels, nor in the severity of the culprit lesion. There were only 3 patients in group-A (6.7%) and 5 patients in group-B (2.1%) with normal coronaries (p=NS). Majority (60%) of the patients in group-A had no significant disease or single vessel disease while majority (69%) of the patients in group-B had two or more vessels involved (p<0.001 ). As far as the number of lesions in the coronary arteries is concerned, 62.3% patients had 2 or lesser lesions in group-A while 68.6% patients in group-B had three or more lesions (p=0.001). CONCLUSION These data suggest that in our study, young patients with MI do not have significantly high prevalence of normal coronaries compared to older patients. Young patients are similar to the older patients with respect to severity of CAD. Lesser number of coronaries is involved and there is lesser number of lesions per patient in young patients compared to older ones.
Fuzzy Modeling Built Through a Data Mining Process

This work uses fuzzy logic to identify the learning profile of students in a teaching and learning environment. The purpose of this identification is to lead the student to more appropriate use of the available resources in the environment. The fuzzy modeling has been developed from a process of data mining. The mined data set has several learning profiles of several students. The classification method called Decision Tree (DT) was applied in the mining process, and for the comparison two algorithms were used. The analysis of data from the DT allowed to validate and improve the results of fuzzy modeling. This validation process can be used in the remodeling of the characteristics of any fuzzy system, it is a way to build a more harmonious and consistent model, in this case, the student profile.
L'écart et l'entre Ou comment penser l'altérité

Dans sa lecon inaugurale, Francois Jullien dresse un bilan de son chantier engage entre pensee chinoise et philosophie ; et presente les voies selon lesquelles il aborde la pensee de l'alterite. Partant de l'exteriorite de la Chine vis-a-vis de la pensee europeenne, il evoque ce qu'a ete la " deconstruction du dehors " entamee a partir de ce detour chinois. Rejetant les notions de difference et d'identite culturelles, il leur substitue les concepts d'ecart et de fecondite ; a partir de quoi il construit un concept de l'entre, genere par l'ecart, et situant le commun de l'humain. Car le commun n'est pas le semblable. Car il convient de refuser a la fois l'universalisme facile et le relativisme paresseux. C'est seulement a partir d'un tel travail que l'on peut concevoir l' " autre " comme categorie mobile, ni aplatie ni non plus absolutisee, qui soit effectivement promotrice de l'humain comme de la pensee.
Amniotic membrane for ocular surface reconstruction: donor variations and the effect of handling on TGF-beta content.

PURPOSE Amniotic membrane (AM) transplantation is an accepted procedure in ocular surgery. However, little is known of the interdonor and intradonor variability within the membrane. In addition, the effects of the methods of processing, storage, and preoperative preparation on the membrane are not fully elucidated. The purpose of this study was to use TGF-beta as an example to investigate interdonor and intradonor variability and to determine the effect of "handling " on TGF-beta1 within fresh, processed and stored, and transplantation-ready AM (TRAM). METHODS Seventeen human AMs, both fresh and handled, were analyzed for TGF-beta1 by real-time polymerase chain reaction, immunohistochemistry, SDS-PAGE, and Western blotting. RESULTS TGF-beta1 was the highest normalized expressed isoform of TGF-beta in all samples, but it varied between membranes of different donors and at different sites within the same membrane. The highest concentration was noted in the spongy layer. Removal of the spongy layer successfully removed the bulk of TGF-beta1 from TRAM. Latency-associated protein (LAP) and a latent TGF-beta-binding protein (LTBP) were also detected. CONCLUSION TGF-beta1 is present in various regulatory forms in the AM. A degree of intermembrane and intramembrane variation is modified by handling. Unless a standardized protocol is adopted that delivers a membrane with consistent constituents, clinical outcomes may vary and comparisons may be invalid.
Biyoloji ve Fen Bilgisi Öğretmen Adaylarının Kullandığı Öğrenme Stratejileri (DEÜ. Örneği)

Bu arastirmanin amaci, Biyoloji ve Fen Bilgisi ogretmen adaylarinin kullandiklari ogrenme stratejilerini saptamaktir. Arastirmanin verileri Biyoloji’de Kullanilan Ogrenme Stratejileri Olcegi ile toplanmistir. Olcek besli Likert tipindedir. Arastirmaya Biyoloji ve Fen Bilgisi Anabilim dalina devam eden birinci ve son sinif ogrencileri (n=200) katilmistir. Arastirmanin verileri istatistiki yontemlerle analiz edilmistir. Arastirmanin sonucunda ogretmen adaylarinin genel olarak ogrenme stratejilerini cok kullandiklari, “onemli gordukleri yerlerin altini cizme” stratejisini her zaman, “soru sorma” stratejilerini ise ara sira kullandiklari belirlenmistir. Kiz ogretmen adaylarinin erkek ogretmen adaylarina gore daha sik ogrenme stratejilerini kullandiklari, kullanilan stratejilerin bolumlere gore anlamli farkliliklar gosterdigi, ancak mezun olunan ortaogretim okullarina gore anlamli farkliliklar gostermedigi saptanmistir
Allopatric origins of microbial species

Although allopatric divergence is a well-accepted mechanism of speciation for eukaryotic macro-organisms, the importance of geographical barriers to divergence in microbial populations is a subject of great debate. Do geographically separated populations of micro-organisms diverge independently, or does their structure fit the often quoted Bass-Becking description ‘everything is everywhere; the environment selects’? Aided by high-resolution genetic and genomic tools, the search for ‘microbial marsupials’ has revealed that in fact both are true; some species of micro-organisms demonstrate allopatric divergence, while others do not. This discovery opens the door for comparative analyses, where questions about the differences in evolutionary and ecological mechanisms that drive divergence and speciation in different microbial species can begin to be explored. Investigating these differences in evolutionary mechanisms will greatly enhance interest in, and understanding of, the dynamic processes that create and maintain the vast diversity of the microbial world.
Lifetime Prevalence and Correlates of Suicidal Ideation, Plan, and Single and Multiple Attempts in a Korean Nationwide Study

This was the first Korean national study to evaluate prevalence and correlates of suicidal behavior, and to compare multiple and single attempts. A total of 6510 adults completed face-to-face interviews (response rate, 81.7%) through randomly chosen one-person-per-households. Lifetime prevalence and correlates were evaluated with the Korean version of Composite International Diagnostic Interview (K-CIDI), and a questionnaire to inquire about suicidal behaviors. The lifetime prevalence of suicidal ideation, plan, and attempt in South Korea was 15.2%, 3.3%, and 3.2% (single 2.1% and multiple 1.1%), respectively. Younger age was associated with attempts and more strongly associated with multiple attempts. Attempts were the most strongly associated with mood disorders, especially bipolar disorder, which was more strongly associated with multiple attempts. In conclusion, suicidal behaviors are highly prevalent in Korea, especially in young adults. Bipolar disorder was the most strongly associated disorder with suicide attempts, more with multiple attempts.