Miracle-dz/UniFAR-FTUs huggingface dataset:
A REVIEW OF PSOAS ABSCESS

Psoas abscess is an uncommon clinical entity that can be primary, following haematogenous dissemination of an aetiologic agent, the source of which is usually occult, or secondary, as a result of local extension of an infectious process near the psoas muscle. The triad of presentation; fever, loin pain and limitation of hip movement, may not be found in all patients. The correct diagnosis can be made with a vigilant clinical examination, epidemiological, microbiological and radiological investigations. The main stay of treatment is medical and or surgical drainage of abscess and treatment of the underlying illness. With the resurgence of tuberculosis, consequent upon the HIV/AIDS pandemic, there has been an increase in the number of psoas abscess due to mycobacterial organisms. This is a review of the literature on psoas abscess with highlights on the mode of presentation, diagnosis and treatment modalities. Key Words: psoas, abscess, review African Journal Of Clinical And Experimental Microbiology Jan 2004 Vol.5 No.1 55-63
apid prediction of sustained virological response in patients chronically infected ith HCV by evaluation of RNA decay 48 h after the start of treatment with egylated interferon and ribavirin

The combination of pegylated interferons (PEG-IFNs) and ribavirin represents the standard of care for the treatment of chronic HCV-infected patients, yet with a success rate around 50% in genotypes 1 and 4, high costs and side effects. Therefore, early prediction of sustained virological response (SVR) is a relevant issue for HCV-patients. We evaluated the association between SVR and decline of HCV-RNA at 48 h in a prospective cohort of 145 HCV-patients treated with PEG-IFNs and ribavirin (males = 69.1%; genotypes 1/4 = 51.0%; HIV-1 coinfected = 6.7%). SVR was obtained in 65.5% of patients, while 16.6% experienced relapse and 17.9% no response. The first-phase of HCV-RNA decline clearly differentiated patients with EG-IFN and ribavirin
Successful percutaneous mitral valve repair with the mitraclip system of acute mitral regurgitation due to papillary muscle rupture as complication of acute myocardial infarction

Percutaneous mitral valve repair with the MitraClip is a new promising therapeutic option for symptomatic severe mitral regurgitation (MR). Acute myocardial infarction (MI) is a well recognized cause of papillary muscle rupture (PMR). If PMR is untreated, the prognosis is poor and the mortality could be as high as 80% during the first week of post MI. For patients with PMR, the standard therapy for MR is open surgical repair or replacement. However, in our case, percutaneous mitral valve repair with the MitraClip was chosen technique because of the metastatic colon cancer. We report the case of a 60‐year‐old woman who underwent successful percutaneous mitral valve repair with the MitraClip system for the treatment of acute MI complicated by PMR. © 2013 Wiley Periodicals, Inc.
Structural dynamics of full-length retroviral integrase: a molecular dynamics analysis

HIV integrase catalyzes the integration between host and viral DNA and is considered as an interesting target for treating HIV. Knowledge of the complete structure of integrase is inevitable to describe the communicative inter-domain interactions affecting the HIV integration and disintegration process and hence the study on full-length integrase turns out to be an essential task. In this investigation, a structure of full-length integrase is designed to analyze the global dynamics of integrase dimer and monomers (with and without the C-terminal, 270–288 amino acids) for a period of 20 ns. The molecular dynamics analysis and the subsequent DynDom analysis reveal (i) a stable dynamics of dimeric CCD and NTD domains and (ii) CCD-α11-mediated rotational-cum-translational CTD motion as the functional dynamics of IN dimer. This observation supports that (i) aggregation enhances the integrase activity and (ii) flexible CTD for its cis and trans coordination with CCD. The role of C-loop over the dynamics of integrase is also explored, which unveils that the spatial arrangement of integrase domains is changed during dynamics in the absence of C-loop. In essence, here we report a C-loop-dependent structural dynamics of integrase and the active dynamics of integrase in dimer. Further studies on C-loop sensing mechanism and the multimerization of integrase would provide insight into HIV integration and disintegration processes. Supplementary material. Movies generated from molecular dynamics trajectory showing the CTD dynamics of IN structures (monomers with & without C-loop and dimer) are linked online to this article. The remaining supplementary data can be downloaded from the author’s server at the URL http://ramutha.bicpu. edu.in.
Age-Related Changes in the Episodic Simulation of Future Events

Episodic memory enables individuals to recollect past events as well as imagine possible future scenarios. Although the episodic specificity of past events declines as people grow older, it is unknown whether the same is true for future events. In an adapted version of the Autobiographical Interview, young and older participants generated past and future events. Transcriptions were segmented into distinct details that were classified as either internal (episodic) or external. Older adults generated fewer internal details than younger adults for past events, a result replicating previous findings; more important, we show that this deficit extends to future events. Furthermore, the number of internal details and the number of external details both showed correlations between past and future events. Finally, the number of internal details generated by older adults correlated with their relational memory abilities, a finding consistent with the constructive-episodic-simulation hypothesis, which holds that simulation of future episodes requires a system that can flexibly recombine details from past events into novel scenarios.
Do Today's Young People Really Think They Are So Extraordinary?

The present research investigated secular trends in narcissism and self-enhancement over the past three decades. Despite recent claims about the impact of the “self-esteem movement” on the current generation of young people, we found no evidence that college students' scores on the Narcissistic Personality Inventory increased from the 1980s through 2007 (N = 26,867), although we did find small changes in specific facets of narcissism. Similarly, we found no evidence that high school students' level of self-enhancement, defined by the discrepancy between their perceived intelligence and their actual academic achievements, increased from 1976 to 2006 (N = 410,527). These results cast doubt on the belief that today's young people have increasingly inflated impressions of themselves compared with previous generations.
Association Between Distilled Spirits Consumption and Violent Mortality Rate

The association between alcohol and violent mortality is well documented. Considerably less is known about the beverage-specific effect of alcohol on mortality rate. The role of drinking patterns in the alcohol-violent mortality association is a very important issue today. Aim: To estimate the beverage-specific effect of alcohol on violent mortality rate. Measurement: Trends in different types of violent mortality rate (mortality due to accidents and injuries, mortality due to suicide and homicide, mortality due to motor-traffic accidents) from 1970-1999 in Belarus were analyzed in relation to trends in the level of different types of alcoholic beverage consumption per capita applying time series, factor and cluster analyses. Results: The results of this study demonstrated a positive and statistically significant effect of changes in strong spirits per capita consumption on violent mortality rate. At the same time, the relationship between the total level of alcohol consumption and different types of violent mortality rates is far below statistical significance. The analysis suggest that a 10% increase in spirits consumption per capita would result in a 7.5% increase in accidents and injuries mortality rate, in a 5% increase in suicide rate, in an 11.4% increase in homicide rate, in a 1% increase in fatal traffic accidents rate. Conclusion: The results of this study support the idea that violent mortality rate tends to be more responsive to changes in distilled spirits consumption per capita than in total level of alcohol consumption. The main evidence for this conclusion is that a positive and statistically significant relationship between violent mortality rate and the level of vodka consumption per capita was revealed. The level of strong spirits consumption per capita is most strongly associated with such indexes as mortality due to homicides, suicides, accidents and injuries, and to a lesser degree with mortality due to road accidents. This study supports the idea that violent mortality and alcohol are more closely connected in culture with prevailing intoxication-oriented drinking patterns and adds to the growing body of evidence that a substantial proportion of violent mortality in Belarus is due to the acute effect of binge drinking.
Interpersonal Politics

Research on terror management theory (TMT) indicates that reminders of death affect political attitudes, but political orientation only sometimes moderates these effects. We propose that secure relationships are associated with values of tolerance and compassion, thus orienting people toward liberalism; insecure attachments are associated with more rigid and absolutist values that orient people toward conservatism. Given that attachment relationships become especially active when security needs are heightened, we predicted that mortality salience would be an important factor in understanding the relationship between attachment processes and political orientation. Supporting these ideas, Study 1 showed that after a mortality-salience manipulation, securely attached participants increased their support for a liberal presidential candidate, and less securely attached participants increased their support for a conservative presidential candidate. In Study 2, a secure-relationship prime following a mortality-salience manipulation engendered a less violent approach to the problem of terrorism than did a neutral-relationship prime. We discuss the interaction of TMT processes and individual differences in attachment in shaping political preferences.
Powerful People Make Good Decisions Even When They Consciously Think

The article presents a study to determine whether the powerful are normally under greater attentional demands than the powerless. This study was participated by 81 undergraduate students to examine whether high-power individuals make equally good decisions following conscious versus unconscious thought. It was found that high-power individuals were equally good at identifying the better choice after conscious versus unconscious thought when given problems that require a complex decision. It also concluded that the powerful seem to be able to handle a number of decisions which have great impact without making excessive errors.
The Role of Pragmatics in Mediating the Relationship Between Social Disadvantage and Adolescent Behavior

Objective: The relationship between social disadvantage, behavior, and communication in childhood is well established. Less is known about how these 3 interact across childhood and specifically whether pragmatic language skills act as a mediator between early social disadvantage and adolescent behavior. Method: The sample was the Avon Longitudinal Study of Parents and Children, a representative birth cohort initially recruited in England in 1991/1992 and followed through to adolescence and beyond. Of the original 13,992 live births, data were available for 2926 children at 13 years. Univariable analysis was first used to identify sociodemographic and other predictors of the Strengths and Difficulties Questionnaire (SDQ) at 13 years. The mediational role of the pragmatics scale of the Children's Communication Checklist (CCC) at 9 years was then tested, controlling for age, gender, and IQ. Results: There was evidence of both a direct effect from social disadvantage (path C′) to SDQ Total Behavior Score at 13 years (−.205; p < .001) and an indirect effect from social disadvantage to SDQ Total (−.225; p < .001) after adjusting for the CCC pragmatics scale as a mediator. The latter represents a reduction in the magnitude of the unadjusted effect or “total effect” (−.430), demonstrating that the pragmatics scale partially mediates the relationship of early social disadvantage and adolescent behavior (even after controlling for other covariates). The same relationship held for all but the pro-social subscale of the SDQ. Conclusion: The results provide evidence to suggest that there maybe a causal relationship between these variables, suggesting that interventions targeting pragmatic skills have the potential to reduce adolescent behavioral symptoms.
Safety and efficacy metrics for primary nitinol stenting in femoropopliteal occlusive disease: A meta‐analysis and critical examination of current methodologies

The efficacy and safety of primary stenting for superficial femoral artery (SFA) disease have been benchmarked against historically derived performance goals. However, contemporary evidence evaluating SFA stenting is accumulating. The objective of this systematic review and meta‐analysis was to quantitatively assess outcomes after primary SFA stenting with nitinol stents in contemporary practice, to compare these rates with commonly used efficacy and safety goals, and to discuss the clinical and regulatory implications of these findings.
Influence of divalent magnesium ion on DNA: molecular dynamics simulation studies

A large amount of experimental evidence is available on the effect of magnesium ions on the structure and stability of DNA double helix. Less is known, however, on how these ions affect the stability and dynamics of the molecule. The static time average pictures from X-ray structures or the quantum chemical energy minimized structures lack understanding of the dynamic DNA–ion interaction. The present work addresses these questions by molecular dynamics simulation studies on two DNA duplexes and their interaction with magnesium ions. Results show typical B-DNA character with occasional excursions to deviated states. We detected expected stability of the duplexes in terms of backbone conformations and base pair parameter by the CHARMM-27 force field. Ion environment analysis shows that Mg2+ retains the coordination sphere throughout the simulation with a preference for major groove over minor. An extensive analysis of the influence of the Mg2+ ion shows no evidence of the popular predictions of groove width narrowing by dipositive metal ion. The major groove atoms show higher occupancy and residence time compared to minor groove for magnesium, where no such distinction is found for the charge neutralizing Na+ ions. The determining factor of Mg2+ ion’s choice in DNA binding site evolves as the steric hindrance faced by the bulky hexahydrated cation where wider major groove gets the preference. We have shown that in case of binding of Mg2+ to DNA non electrostatic contributions play a major role. An animated Interactive 3D Complement (I3DC) is available in Proteopedia at http://proteopedia.org/w/Journal:JBSD:5
mulPBA: an efficient multiple protein structure alignment method based on a structural alphabet

The increasing number of available protein structures requires efficient tools for multiple structure comparison. Indeed, multiple structural alignments are essential for the analysis of function, evolution and architecture of protein structures. For this purpose, we proposed a new web server called multiple Protein Block Alignment (mulPBA). This server implements a method based on a structural alphabet to describe the backbone conformation of a protein chain in terms of dihedral angles. This ‘sequence-like’ representation enables the use of powerful sequence alignment methods for primary structure comparison, followed by an iterative refinement of the structural superposition. This approach yields alignments superior to most of the rigid-body alignment methods and highly comparable with the flexible structure comparison approaches. We implement this method in a web server designed to do multiple structure superimpositions from a set of structures given by the user. Outputs are given as both sequence alignment and superposed 3D structures visualized directly by static images generated by PyMol or through a Jmol applet allowing dynamic interaction. Multiple global quality measures are given. Relatedness between structures is indicated by a distance dendogram. Superimposed structures in PDB format can be also downloaded, and the results are quickly obtained. mulPBA server can be accessed at www.dsimb. inserm.fr/dsimb_tools/mulpba/.
The Utility of a Continuous Performance Test Embedded in Virtual Reality in Measuring ADHD-Related Deficits

Objective: Continuous performance tasks (CPT) are popular in the diagnostic process of Attention Deficit/Hyperactivity Disorder (ADHD), providing an objective measure of attention for a disorder with otherwise subjective criteria. Aims of the study were to: (1) compare the performance of children with ADHD on a CPT embedded within a virtual reality classroom (VR-CPT) to the currently used Test of Variables of Attention (TOVA) CPT, and (2) assess how the VR environment is experienced. Methods: Thirty-seven boys, 9 to 17 years, with (n = 20) and without ADHD (n = 17) underwent 3 CPT’s: VR-CPT, the same CPT without VR (No VR-CPT) and the TOVA. Immediately following CPT, subjects described their subjective experiences on the Short Feedback Questionnaire. Results were analyzed using analysis of variance with repeated measures. Results: Children with ADHD performed poorer on all CPT’s. The VR-CPT showed similar effect sizes to the TOVA. Subjective feelings of enjoyment were most positive for VR-CPT. Conclusion: The VR-CPT is a sensitive and user-friendly assessment tool to aid diagnosis in ADHD.
Identification of Families At Risk for Behavior Problems in Primary Care Settings

Objective: Parenting practices and cognitions are associated with child externalizing behavior problems. Parenting programs targeting these areas are effective in improving child behavior but are limited to the extent to which they reach at-risk families. This study compared the parenting practices and cognitions of parents with high and low tolerance for misbehavior to parents of children with clinically significant behavior problems to evaluate the utility of assessing parental tolerance for identifying children at risk for externalizing behavior problems. Methods: Participants were 1014 parents of children between the ages of 2 and 16 years presenting for primary care. Parents completed the Eyberg Child Behavior Inventory, Parenting Scale, and Parenting Sense of Competence Scale. Results: Parents with high and low tolerance resembled the clinically significant problem groups in both parental behaviors and cognitions. Differences regarding parental cognitions were consistent across all age groups assessed. Conclusions: This study demonstrated the clinical utility of interpreting caregiver responses to questions about the intensity of their child's behavior problems and parental tolerance for these problems separately. Results indicated that parents with high or low tolerance for their child's behavior are at risk of having children with clinically significant behavior problems. Parents who are concerned about their child's behavior, even if their child does not currently exhibit clinically significant behavior problems, are likely to profit from early intervention for behavior problems.
The Effects of Different Types of High Heels and Walking Velocity on Muscle Activation of the Paraspinal Muscles

The 28 subjects in this experiment were females in their 20s with a foot size of 225-230 ㎜. To measure the muscle activation of the paraspinal muscles, EMG electrodes were attached on the paraspinal muscles around C6, T7, and L5. The muscle activation during walking while wearing 8 ㎝ high wedge heels, setback heels, and french heels was measured. The measurements were performed 3 times each and the mean value of the result was used for analysis. Two kinds of velocity were used in this study. One of the velocity was 2.5 ㎧. The other was 3.5 ㎧.
Development of a work addiction scale.

Research into excessive work has gained increasing attention over the last 20 years. Terms such as "workaholism,""work addiction" and "excessive work" have been used interchangeably. Given the increase in empirical research, this study presents the development of the Bergen Work Addiction Scale (BWAS), a new psychometrically validated scale for the assessment of work addiction. A pool of 14 items, with two reflecting each of seven core elements of addiction (i.e., salience, mood modification, tolerance, withdrawal, conflict, relapse, and problems) was initially constructed. The items were then administered to two samples, one recruited by a web survey following a television broadcast about workaholism (n = 11,769) and one comprising participants in the second wave of a longitudinal internet-based survey about working life (n = 368). The items with the highest corrected item-total correlation from within each of the seven addiction elements were retained in the final scale. The assumed one-factor solution of the refined seven-item scale was acceptable (root mean square error of approximation = 0.077, Comparative Fit Index = 0.96, Tucker-Lewis Index = 0.95) and the internal reliability of the two samples were 0.84 and 0.80, respectively. The scores of the BWAS converged with scores on other workaholism scales, except for a Work Enjoyment subscale. A suggested cut-off for categorization of workaholics showed good discriminative ability in terms of working hours, leadership position, and subjective health complaints. It is concluded that the BWAS has good psychometric properties.