Miracle-dz/UniFAR-FTUs huggingface dataset:
Towards a ‘map’ of panic: structure of the bodily symptoms

Despite the large amount of research on panic attacks according to DSM criteria, there are some inconsistencies between this and reports from clinical settings. Some naturalistic and non‐standard studies are needed. The authors of the present study submitted a list of 24 bodily symptoms to 65 panic patients who had sought medical help. The results of principal‐component analysis revealed five factors, four of which represent the forms described in clinical and epidemiological contexts: cephalo‐vertiginous, cervico‐respiratory, thoraco‐cardiac and abdomino‐digestive. Each of these factors is differentially related to some specific fearful anticipations, which may organize the symptoms in a body‐related topographical way.
Modified artificial bee colony algorithm for optimal distributed generation sizing and allocation in distribution systems

This paper presents a modification in the neighboring search of the artificial bee colony (ABC) algorithm. The ABC algorithm is a new meta-heuristic population-based optimization technique inspired by the intelligent foraging behavior of honeybee swarms. To verify the validity of the proposed modified ABC algorithm, the problem of determining the optimal size, location and power factor for a distributed generation (DG) to minimize total system real power loss is considered. The IEEE 33-bus and 69-bus feeder systems are examined, and the results obtained by the proposed algorithm are compared with those found using other methods. The outcomes verify that the modified ABC algorithm has excellent solution quality and convergence characteristics. The efficiency of the proposed algorithm lies in the fact that the standard deviation of the attained results for 30 independent runs at every test case is virtually equal to zero.
Release Factor eRF3 Mediates Premature Translation Termination on Polylysine-Stalled Ribosomes in Saccharomyces cerevisiae

ABSTRACT Ribosome stalling is an important incident enabling the cellular quality control machinery to detect aberrant mRNA. Saccharomyces cerevisiae Hbs1-Dom34 and Ski7 are homologs of the canonical release factor eRF3-eRF1, which recognize stalled ribosomes, promote ribosome release, and induce the decay of aberrant mRNA. Polyadenylated nonstop mRNA encodes aberrant proteins containing C-terminal polylysine segments which cause ribosome stalling due to electrostatic interaction with the ribosomal exit tunnel. Here we describe a novel mechanism, termed premature translation termination, which releases C-terminally truncated translation products from ribosomes stalled on polylysine segments. Premature termination during polylysine synthesis was abolished when ribosome stalling was prevented due to the absence of the ribosomal protein Asc1. In contrast, premature termination was enhanced, when the general rate of translation elongation was lowered. The unconventional termination event was independent of Hbs1-Dom34 and Ski7, but it was dependent on eRF3. Moreover, premature termination during polylysine synthesis was strongly increased in the absence of the ribosome-bound chaperones ribosome-associated complex (RAC) and Ssb (Ssb1 and Ssb2). On the basis of the data, we suggest a model in which eRF3-eRF1 can catalyze the release of nascent polypeptides even though the ribosomal A-site contains a sense codon when the rate of translation is abnormally low.
Language Shift Revisited. Linguistic Repertoires of Jews in Low German-Speaking Germany in the Early 20th Century: Insights from the LCAAJ Archive

This paper analyzes the linguistic repertoires of Jews in the Low German-speaking areas in the first decades of the 20th century, as a contribution to historical sociolinguistics. Based on fieldwork questionnaires held in the archives of the Language and Culture Atlas of Ashkenazic Jewry (LCAAJ), it addresses the question of whether the Jewish minorities spoke a supralectal form of standard German or Koiné forms of dialects, relating this to issues of language shift from Western Yiddish. The study shows that many Jews living in northern Germany during the 1920s and 1930s still had access to a multilingual repertoire containing remnants of Western Yiddish; that a majority of the LCAAJ interviewees from this area emphasized their excellent command of standard German; and that their competence in Low German varied widely, from first language to no competence at all, depending on the region where they lived. *
Effects of low air pressure on AC and DC arc propagation on ice surface

The effects of air pressure on the AC and DC arc process on an ice surface, including velocity, parameters and flashover voltage, were studied. The results obtained showed that air pressure has an obvious influence on the arc propagation velocity, arc constant A, electrode voltage drop Ve and consequently on the flashover voltage of the ice surface, Vf. This decrease in Vf is explained by the decrease in the E-I arc characteristics and arc propagation velocity, and by the relatively higher density of Na atoms in the arcs at pressures below standard air pressure. Based on these results, the mechanism underlying the decrease in the flashover voltage of ice-covered insulators at high altitude was analyzed
Eleven phthalate esters and di(2-ethylhexyl) adipate in oneweek duplicate diet samples obtained from hospitals and their estimated daily intake

Plasticizers in duplicate diet samples obtained over 1 week were analysed in order to estimate daily intake. The phthalate esters were as follows: diethyl, dipropyl, dibutyl, dipentyl, dihexyl, butylbenzyl, dicyclohexyl, di(2-ethylhexyl), dioctyl, diisooctyl (mixture of isomers) and diisononyl (mixture). Di(2-ethylhexyl) adipate was also determined. Homogenized samples of composite meals were extracted with acetonitrile, lipids were removed by extraction into n-hexane and the acetonitrile layer was cleaned using FlorisilR and Bondesil PSAR dual layer column. Phthalates were determined by GC/MS (SIM). Phthalate recovery from the fortified food mixture by this method was 62.5–140.8%. Quality assurance as assessed by three laboratories indicated coefficient of variance in the levels of detected phthalates in same lot samples as below 10%. Detection limits were 0.1–23ng/g for each phthalate. One-week duplicate diet samples provided by three hospitals in three remote prefectures of Japan were analysed as individual meals. In all 63 samples, DEHP was present at the highest level among all phthalates in the range 10–4400ng/g. The intake of plasticizers estimated from all samples was 519 μg DEHP/day, 86 μg DEHA/day, 65 μg DINP/day, and 4.7 μg BBP/day. Calculated DEHP in 2-day samples out of 21 days exceeded EU TDI for a person of 50kg body weight (1850 μg per day). Disposable PVC gloves used during the preparation of meals were suspected as the source of the high DEHP content. One-day intake of the other phthalates and DEHA was below 7% of TDI in all cases. High concentrations of DEHP (5990ng/g) was found in baby food used in quality assurance work. The source of contamination was the PVC-tube used during production and was effectively reduced by replacing the tube by one made of stainless steel.
Neural mechanisms underlying behavior in the locust Schistocerca gregaria. I. Physiology of identified motorneurons in the metathoracic ganglion.

A preparation of the desert locust, Schistocera gregaria, has been developed, in which it was possible to work with identified neurons while still allowing some behavior. A total of 26 motorneurons to the hind leg were studied singly, and in various pairs, both by direct stimulation, and by recording during spontaneous activity and various reflex actions. Motorneurons were identified by passing current into their somata and correlating the evoked somata spikes with extracellularly or intracellularly recorded events in the muscles. Tension of the muscle was also recorded and motor axons were stimulated to evoke antidromic spikes in the somata. Both epsp's and ipsp's can be seen clearly in recordings from the somata; spikes appear as electrotonically conducted remnants only. Somata exhibited little or no electrogenesis. It is inferred that impulses are initiated in a zone tentatively identified with the region of emergence of the motor axon from the neuropil. Integration occurs in the neuropilar segment, with the soma serving as a parallel RC element. Data was obtained on the central mechanisms of coordination of synergistic and antagonistic motorneurons and on the modes of excitation of slow and fast neurons to the same muscles.
Wide Band Frequency Characterization of Al-Doped and Undoped Rutile TiO2 Thin Films for MIM Capacitors

In this letter, the dielectric properties of rutile TiO2 thin films are studied for metal–insulator–metal capacitor applications. The dielectric constant, the ac conductivity, and the loss tangent are measured in a wide band frequency range, from 1 Hz to 2 GHz. The effect of aluminum doping, as well as the influence of film thickness, on the dielectric properties is presented.
Endocarditis in a dog due to infection with a novel Bartonella subspecies

Vegetative valvular endocarditis involving the aortic and, to a lesser extent, mitral valves was diagnosed echocardiographically in a 3-year-old spayed female Labrador retriever. Historically, the dog had been treated with tetracycline hydrochloride and prednisolone for positive seroreactivity to Ehrlichia canis and antinuclear antigens. Although three aerobic and anaerobic blood cultures failed to grow bacteria, blood cultured simultaneously by the lysis centrifugation technique grew a fastidious, gram-negative organism. Despite an initial therapeutic response, the owner elected euthanasia 17 days later. Necropsy confirmed aortic and mitral valvular endocarditis. Bacteria phenotypically similar to Bartonella species were visualized in the heart valve by light and electron microscopy, and Bartonella DNA from a frozen heart valve was amplified by PCR. Subsequent phenotypic and genotypic characterization of the isolate, including biochemical testing, cellular fatty acid analysis, DNA hybridization, and sequencing of the 16S rRNA gene indicated that this organism, which can induce endocarditis in dogs, is a novel Bartonella subspecies containing an insertion sequence unique among currently recognized Bartonella species. The name Bartonella vinsonii subsp. berkoffii subsp. nov. will be proposed for this organism.
Objective and Subjective Components of the First-Night Effect in Young Nightmare Sufferers and Healthy Participants

The first-night effect—marked differences between the first- and the second-night sleep spent in a laboratory—is a widely known phenomenon that accounts for the common practice of excluding the first-night sleep from any polysomnographic analysis. The extent to which the first-night effect is present in a participant, as well as its duration (1 or more nights), might have diagnostic value and should account for different protocols used for distinct patient groups. This study investigated the first-night effect on nightmare sufferers (NM; N = 12) and healthy controls (N = 15) using both objective (2-night-long polysomnography) and subjective (Groningen Sleep Quality Scale for the 2 nights spent in the laboratory and 1 regular night spent at home) methods. Differences were found in both the objective (sleep efficiency, wakefulness after sleep onset, sleep latency, Stage-1 duration, Stage-2 duration, slow-wave sleep duration, and REM duration) and subjective (self-rating) variables between the 2 nights and the 2 groups, with a more pronounced first-night effect in the case of the NM group. Furthermore, subjective sleep quality was strongly related to polysomnographic variables and did not differ among 1 regular night spent at home and the second night spent in the laboratory. The importance of these results is discussed from a diagnostic point of view.
Comment on Dissociation between running economy and running performance in elite Kenyan distance runners

Abstract Mooses and colleagues suggest that running economy alone does not explain superior distance running performance in elite Kenyan runners. Whilst we agree with the multi-factorial hypothesis for Kenyan running success, we do not believe that running economy can be overlooked to the extent that it was based on this particular study. Based on the methods used and the range of athletes tested, in this response letter we question whether this study provides any basis for downplaying the influence of running economy or suggesting that other factors compensate for it to enable superior performance.
Plasticity of melanoma in vivo: murine lesions resulting from Trp53, but not Cdk4 or Arf deregulation, display neural transdifferentiation

We previously noted that melanomas developing in Cdk4R24C/R24C::Tyr‐NRAS, Arf−/−::Tyr‐NRAS and Trp53F/F::Tyr‐Cre(ER)::Tyr‐NRAS mice exhibited differences in behaviour in vivo. We investigated this phenomenon using global gene expression profiling of lesions from the respective genotypes. While those from the Cdk4‐ and Arf‐mutant mice exhibited similar profiles, the Trp53F/F::Tyr‐Cre(ER)::Tyr‐NRAS melanomas were strikingly different, showing relative down‐regulation of melanocyte‐related genes, and up‐regulation of genes related to neural differentiation. Specifically, they highly expressed genes representative of the myelin‐producing peripheral oligodendrite (Schwann cell) lineage, although histopathologically the lesions did not exhibit the classical features of schwannoma. As Schwann cell precursors can be a cellular origin of melanocytes, it is unsurprising that plasticity with respect to melanocyte‐neural differentiation can occur in melanoma. What is surprising is the genotype proclivity. Comparison of gene expression signatures revealed that melanomas from the Trp53‐mutant mice show significant similarities with a subset of aggressive human melanomas with relatively low levels of MITF.
A study of factors influencing the sensitivity to antibody of tanned, ovalbumin-coated, formalinized sheep red cells.

Comparative tests were done to find the best conditions under which formalinized sheep red cells can be tanned and then coated with chromatographically purified ovalbumin. Variation in the time taken for tanning or coating, the amount of antigen used, the temperature during coating, the use of different batches of tannic acid, ovalbumin or of cells formalinized by different methods had little effect on sensitivity to agglutination by antibody. A slight increase in sensitivity was obtained by coating at a low pH, by increasing the quantity of tannic acid employed and by heat denaturation of the antigen.
Identification of new serum autoantibodies in neuromyelitis optica using protein microarrays

Neuromyelitis optica (NMO) or Devic’s disease is a severe demyelinating disease of the CNS affecting primarily optic nerves and spinal cord, secondary to a B-cell- and Ab-mediated autoimmune condition.1 This concept was recently bolstered by the demonstration of disease-specific NMO-Abs,2 and the apparent beneficial effect of B-cell depletion.3 Here, we used a protein microarray approach to profile the Ag reactivity of serum IgG from NMO patients. Sera from five patients fulfilling NMO criteria (Cases 2 through 6 described elsewhere3) and five healthy controls were tested. Because patients experienced relapses and progressive clinical impairment despite therapy, they received rituximab as an off-label, innovative treatment.3 A 20-year-old woman with NMO associated with a high relapse rate (19 relapses within the last 6 years) was blind, wheelchair bound, and had a mid-thoracic sensory level and urinary and stool incontinence. Following treatment with rituximab, she experienced improved strength and sensation in her legs. She had an attack of myelitis approximately 1 month after her first course of rituximab from which she recovered spontaneously without additional treatment. At 1 year follow up, her vision remained impaired but she recovered full strength in her legs, normal …
Preventing Childhood Caries

The etiology of dental caries reflects a complex interplay of biochemical, microbial, genetic, social and physical environmental, and health-influencing behavioral factors. This review updates the literature on the efficacy of behavioral approaches to caries prevention for children up to 18 y of age. Included were studies of behavioral interventions implemented at individual, family, and community levels that assessed results in terms of reductions in caries increments. Only those reports published since 2011 were considered. Outcomes were variable, although motivational interviewing, which involves individuals in decisions about oral health within the context of their respective life circumstances, proved effective in 3 of 4 reported studies, and more definitive trials are underway. Recommendations for future research include examinations of the cost-effectiveness of interventions, as well as work focused on understanding the mechanisms underlying oral health behavior change and variables that may mediate or moderate responses to interventions.
Rumen Fermentation Pattern in Buffaloes as Affected by Mode of Urea Supplementation

Studies on rumen fermentation pattern were conducted in an experiment based on 4x4 latin square design. Four adult male buffaloes fitted with rumen cannulae were taken to evaluate the effect of mode of urea supplementation. Animals in group T1 (control) were given concentrate mixture and wheat straw whereas in the 3 experimental groups (T2-T4), 30% of the total CP requirement was met through urea included in the concentrate mixture (T2), wheat straw (T3) or fed as urea ammoniated wheat straw (T4). The pH of rumen liquor in T2 was significantly (P<0.01) higher as compared to other groups. TVFA concentration was significantly (P<0.01) higher in T4 than T1 or T2 and comparable with T3 The rumen NH3-N concentration was significantly lower in T1 than T2,. T4 and comparable with T3, The TCA ppt-N content of rumen liquor was significantly (P<0.01) higher in T4 as compared to other groups. Various end products of rumen fermentation showed favourable response when urea was incorporated in the diet of animals spraying on straw (T3) or in form of urea ammoniated wheat straw.
Magnetic resonance imaging and 3-dimensional transperineal ultrasound evaluation of pelvic floor dysfunction in symptomatic women: a prospective comparative study

Purpose The purpose of this study was to investigate magnetic resonance imaging (MRI) and 3-dimensional transperineal ultrasound (3D-TPUS) features of pelvic floor dysfunction (PFD) in symptomatic women in correlation with digital palpation and to define cut-offs for hiatal dimensions predictive of muscle dysfunction. Methods This prospective study included 73 women with symptoms suggesting PFD. 3D-TPUS, MRI, and digital palpation of the levator ani muscle were performed in all patients. Levator hiatal antero-posterior (LHap) diameter and area (LH area) were measured at rest and at maximum muscle contraction. Results The reduction in LHap diameter and LH area during contraction was significantly less in women with underactive pelvic floor muscle contraction (UpfmC) than in those who had normal pelvic floor muscle contraction by digital palpation (P<0.001). Statistically significant positive correlations (P<0.001) were found between the Modified Oxford Score and 3D-TPUS and MRI regarding the reduction in the LHap diameter (r=0.80 and r=0.82, respectively) and LH area (r=0.60 and r=0.70, respectively). A reduction in LHap of <6.5% on 3D-TPUS and <7.6% on MRI predicted UpfmC with sensitivities of 46.2% and 82.7%, respectively. A reduction in LH area of <3.4% on 3D-TPUS and <3.8% on MRI predicted UpfmC with sensitivities of 75.0% and 88.5%, respectively. MRI was more sensitive in detecting levator avulsion (63.4%) than 3D-TPUS (27.1%). Conclusion MRI and 3D-TPUS had strong positive correlations with findings on palpation, and at certain cut-offs for hiatal dimensions, they can be used as complementary and objective tools to improve the accuracy of diagnosis and management planning of PFD.
Cancer‐related health worries and psychological distress among older adult, long‐term cancer survivors

While long‐term survivors (5 years+) do not face the stressors of diagnosis and treatment, they continue to face the uncertainties that survivorship brings: recurrence, other cancers, late effects of treatment, and the potential of a shortened life expectancy. This research focuses on the cancer‐related health worries of older adult, long‐term cancer survivors, the factors that predict these worries, and their link to traditional measures of psychological distress. Specifically, a model is proposed that identifies the personal (including race and gender) and illness/treatment characteristics of survivors that are significantly associated with cancer‐related health worries and their effects on anxiety and depression. Descriptive and multivariate analyses of a random sample of 321 long‐term survivors in a major cancer center tumor registry are used to address these issues. About one‐third of survivors continue to report worries about recurrence, worries about a second cancer, and worries that symptoms they experience may be from cancer. The regression analyses show that cancer‐related health worries is a significant predictor of both depression (beta=0.36) and anxiety (beta=0.21). Race is a significant predictor; being African American is related to fewer cancer‐related health worries (beta=−0.22). Having more symptoms during treatment is also a predictor of having more cancer‐related health worries (beta=0.20). The most consistent predictor of psychosocial distress is dispositional optimism/pessimism, with more optimistic individuals reporting fewer cancer‐related health worries (beta=−0.27), lower levels of both anxiety (beta=−0.16) and depression (beta=−0.23). Overall, for many older adult, long‐term survivors, the legacy of cancer continues in terms of cancer‐related health worries. In spite of these, for most survivors, their quality of life is not dramatically compromised either physically or psychologically. Copyright © 2005 John Wiley & Sons, Ltd.
Enzyme-linked immunosorbent assay for detection of measles antibody

An enzyme-linked immunosorbent assay (ELISA) was developed for the detection of measles immunoglobulin G antibody (MEASELISA). This assay was found to be comparable to the measles hemagglutination inhibition (HAI) test. Approximately 500 sera from three centers were tested by MEASELISA and the HAI test. MEASELISA demonstrated values of greater than 99% for sensitivity, specificity, and accuracy. Values were very precise, with a mean coefficient of variation of 5.4%. MEASELISA values were shown by linear regression analysis to increase as HAI titers increased. A coefficient of determination of 1.00 was obtained from test center three. MEASELISA values were found to be linearly related (r2 greater than 0.97) to MEASELISA titers, thus enabling quantitation of measles antibody from a single value. Also, data are presented that show MEASELISA to be equivalent to complement fixation for evaluating paired sera for the presence of a significant increase in antibody levels to measles virus.