Miracle-dz/UniFAR-FTUs huggingface dataset:
On Universals

The philosophical dispute over whether there are universale, or abstract entities, is not a dispute over the admissibility of general terms. Both sides will agree that general terms, e.g. ‘man,’ and perhaps even abstract singular terms such as ‘mankind’ and ‘7’, are meaningful, in the sense at least of participating in statements which as wholes are true or false. Where the platonists (as I shall call those who accept universale) differ from their opponents, the nominalists, is in positing a realm of entities, universals, corresponding to such general or abstract words. The platonist is likely to regard the word ‘man’ as naming a universal, the class of men or the property of being a man, much as the word ‘Caesar’ names the concrete object Caesar. Actually, however, this is an extraneous detail. The platonist could equally well concur with the nominalist in the view that general terms, though meaningful in context, are not names at all.
The relationship between energy expenditure and environmental temperature in congenitally obese and non‐obese Zucker rats.

The energy expenditure of normal and congenitally obese adult female Zucker rats has been measured by continuous indirect calorimetry for periods of 3‐10 days at ambient temperatures varied from 30 to 5 degrees C. Rectal temperatures were also recorded. Exposure to cold caused no ill‐effects in normal or obese rats. The rectal temperatures of obese rats were about 1 degree C lower than those of normal rats. The rectal temperatures of normal rats did not change measurably with ambient temperature; in obese rats rectal temperature rose slightly as ambient temperature fell. In normal and obese rats, energy expenditure showed a smooth, steeply sloping, negative relationship to ambient temperature. Energy expenditure per rat was higher in obese than in normal rats at all temperatures. The two slightly curvilinear regressions were nearly 'parallel', with a separation of about 40 kJ/day per rat at the mid‐point. This study therefore does not confirm suggestions that obese Zucker rats suffer from a defect in the level of energy expenditure, or in their capacity to increase it when exposed to cold. It is suggested that in both normal and obese rats the level of energy expenditure was determined by thermoregulatory control. The greater heat production of obese rats may have been a response to their lower core temperature. A steady state in which greater heat production is associated with lower core temperature implies lower insulation between body core and surface. This could be due to greater blood flow.
Outcomes of patients completing and not completing cognitive therapy for depression.

OBJECTIVES The aims of this study were to use symptom intensity measures collected at each session (1) to describe the outcomes of clients who received cognitive therapy (CT) for depression in a clinically representative sample, and (2) to compare the outcomes of clients who completed the agreed number of sessions with those who did not. DESIGN AND METHOD Clients (N = 58) contracted to attend between 12 and 20 sessions of CT completed the Beck Depression Inventory (BDI) immediately prior to each therapy session. The BDI and other measures were collected at intake and, for those who completed therapy, at a post-therapy assessment. RESULTS Completers' BDI scores improved significantly from intake to post-treatment and significantly more from intake to their final session than did those of non-completers. However, when non-completers' final session scores were matched with scores of randomly selected completers at the corresponding session, the difference in improvement was not significant. A significantly higher proportion of clients who completed the agreed number of sessions achieved reliable and clinically significant change (71.4%, 25/35), compared with just 13% (3/23) of clients who did not. CONCLUSIONS (1) CT for depression can be effective in a clinically representative population. (2) Attrition from clinical trials may bias estimates of treatment effectiveness.
Retention in methadone maintenance drug treatment for prescription-type opioid primary users compared to heroin users.

AIMS To assess retention in methadone maintenance treatment for prescription-type opioid primary (PTOP) users compared to heroin users. DESIGN AND PARTICIPANTS A retrospective cohort study was carried out to examine the association between opiate types used on 12-month retention. The study population consisted of adults admitted to one of 11 not-for-profit methadone maintenance clinics in 2004 and 2005 throughout Washington State (n = 2308). Logistic regression analyses with fixed effects for treatment agencies were conducted. MEASUREMENTS Opiate use type in past 30 days: any heroin use or primary prescription opioid without heroin use. Demographics, other drugs used, self-reported medical and psychiatric concerns, social, familial and legal issues, public assistance type and housing stability were documented at intake using a comprehensive biopsychosocial instrument, the Treatment and Assessment Reports Generation Tool. FINDINGS The odds of being retained in treatment for PTOP compared to heroin users not adjusting for other factors was 1.33 (95% confidence interval [CI], 1.03, 1.71). In the final logistic regression model the odds of retention for PTOP compared to heroin users was 1.25 (95% CI, 0.93, 1.67), indicating that there was no statistically significant difference in treatment retention by opiate type after adjusting for demographics, treatment agencies, other drug use, public assistance type, medical, psychiatric, social, legal and familial factors. CONCLUSION The findings of this study suggest that PTOP can be treated at methadone maintenance treatment facilities at least as effectively as heroin users in terms of treatment retention.
Torulopsis glabrata Osteomyelitis: A Case Report

Skeletal infection involving Torulopsis glabrata is extremely rare. A 66-year-old woman developed Torulopsis glabrata osteomyelitis during a course of prolonged antibiotic therapy for staphylococcal pneumonia that occurred as a postoperative complication of a total knee arthroplasty for osteoar-thritis. Roentgenograms and a biopsy sample revealed a destructive inflammatory lesion of the vertebrae. The presence of the yeast organism in the lesion was demonstrated definitively by culture and tissue pathology, removing any doubt about the pathogenicity of the organism. The disease was successfully treated with 5-fluorocytosine, and the patient recovered without functional impairments.
Association of Rho/Rho-kinase gene polymorphisms and expressions with obesity-related metabolic syndrome.

OBJECTIVE The metabolic syndrome (MetS) is a common multicomponent condition including abdominal obesity, dyslipidemia, hypertension and hyperglycemia. The aim of this study was to investigate the associations of Rho GTPase and Rho-kinase (ROCK) gene polymorphisms and expressions with MetS in a Turkish population. PATIENTS AND METHODS A total of 141 obese MetS patients and 163 healthy controls with similar age and sex were included to this study. Polymorphisms were analyzed in genomic DNA using a BioMark 96.96 dynamic array system. mRNA from blood samples was extracted, and real-time polymerase chain reaction was performed for gene expressions. RESULTS We observed that genotype (CC, 18.1%; CA, 13.4%, and AA, 68.5%) and allele (C, 24.8%; A, 75.2%) frequencies for the rs35996865 polymorphism of the ROCK1 gene in patients were markedly different from controls (CC, 84.2%; CA, 2.9%, and AA, 12.9%; C, 85.6%; A, 14.4%, p < 0.0001). In the rs2230774 (Thr431Asn) polymorphism of the ROCK2 gene, there were increases in the CC genotype (16.5%) and C allele frequencies (20.4%) in MetS patients when compared with the control group (CC, 6.0%, p = 0.0009, and C, 6.7%, p < 0.0001). However, no associations with the other 18 polymorphisms studied were found. Although there were an increase in peripheral blood mRNA RhoH expressions, marked decreases in RhoC, RhoBTB1, RhoV, Rnd1, and CDC42 gene expressions were noted in MetS patients. CONCLUSIONS This is the first study to provide evidence that ROCK gene polymorphisms and gene expressions of the Rho GTPase proteins may modify individual susceptibility to MetS in the Turkish population.
Calibration of thermocouples for low temperature applications

In this communication, concept of enhancement of instrument accuracy in providing measuring values is been discussed. One way to increase instrument accuracy is through calibration technique. K-type thermocouple wire as got advantage of low cost of operation but with decreased accuracy. To overcome this disadvantage, Oil bath, a standard instrument for maintaining constant temperature is considered as reference and calibration of K-type thermocouples is carried out. This study led to the observation that variation in the values of oil temperature and thermocouples varies linearly with respect to each other at every particular temperature, thus utilizing mathematical procedure of linear regression analysis appeared suitable to find out the error in thermocouple readings. Linear regression method provides close approximations (at least within a given range of interest) to relationships which would otherwise be difficult to describe in mathematical terms. This study concluded that similar procedure can be adopted for calibration of other doubtful electrical and electronic instruments, thus increasing their accuracy.
Postpartum return to smoking among usual smokers who quit during pregnancy.

BACKGROUND Many women stop smoking while they are pregnant, but the majority resume smoking in the postpartum. The objective is to describe postpartum tobacco use of women who quit during pregnancy and factors predicting postpartum smoking relapse. METHODS Secondary analysis of two surveys of new mothers. Survey A conducted in three maternity hospitals, including 685 women interviewed after birth and who answered a postal questionnaire at 5 months postpartum; survey B conducted in four 'départements' (administrative areas), including 636 women who answered a postal questionnaire at 6 months postpartum. Response rates were respectively 90% and 68%. Smoking status was recorded for three time periods: before pregnancy, during pregnancy, and at 5-6 months. Social characteristics and preventive behaviour were compared for regular smokers who had quit smoking during pregnancy and those who had not, and among quitters, who had resumed smoking postpartum and those who had not. RESULTS In survey A, 37% were smokers before pregnancy, 34% of them stopped during pregnancy, and among the latter, 48% had resumed smoking 5-6 months after delivery. In survey B, the percentages were respectively 43, 54 and 57%. The most predictive factor of postpartum smoking relapse was the partner's smoking behaviour. CONCLUSION Return to smoking after delivery is frequent, but nearly half of the regular smokers who had stopped during pregnancy were still non-smokers 5-6 months after the birth. However, to increase this proportion, interventions need to include partners, especially if they are smokers.
Clinical Features of Late-onset Ankylosing Spondylitis: Comparison with Early-onset Disease

Objective. Ankylosing spondylitis (AS) is generally observed in young patients but can occur later in life or in persons ≥ 50 years of age. Our objective was to characterize the clinical features of late-onset AS in a large multicenter national cohort. Methods. We studied late-onset AS in the National Registry of Spondyloarthritis of the Spanish Society of Rheumatology (REGISPONSER database) cohort (n = 1257), of whom 3.5% had onset at age ≥ 50 years versus a control group with onset at < 50 years. Results. There were no differences between late-onset and early-onset AS according to sex and family history of spondyloarthropathies. Patients in the late-onset group more often showed involvement of the cervical spine (22.7% vs 9.7%; p = 0.03) and arthritis of the upper (13.6% vs 3.0%; p = 0.002) and lower limbs (27.3% vs 15.2%; p = 0.03) as first manifestations than did patients in the early-onset group. A higher percentage of mixed forms (axial and peripheral joint disease) during the course of the disease was also recorded in the late-onset group (50% vs 24%; p = 0.0001). Conclusion. Our study suggests that age at onset of AS affects the patients’ presenting clinical form. Arthritis of the upper limbs requires a differential diagnosis with other conditions frequent in patients over 50 years of age, such as rheumatoid arthritis or crystal-induced arthropathy.
cDNA array reveals differential gene expression following chronic neuroleptic administration: implications of synapsin II in haloperidol treatment

The cDNA expression array is a recently developed scientific tool that can profile the differential expression of several hundreds of genes simultaneously and is therefore advantageous in the study of antipsychotic drug action at the genetic level. Using this technology, we discovered 14 genes in the rat striatum whose expression was changed by ≥ 50% following chronic haloperidol treatment. Among them was the synapsin II gene, which was found to be significantly up‐regulated after the treatment. Since recent studies have implicated this gene in schizophrenia, further experiments were performed to determine whether chronic haloperidol exposure resulted in concurrent increases in the expression of striatal synapsin II protein. Immunoblotting revealed that protein levels of both the a and b isoforms of synapsin II were also increased by comparable amounts following haloperidol treatment. This study is the first to show the regulation of synapsin II expression by haloperidol at the transcript and protein level in rat striatum. A possible mechanism for the observed haloperidol‐induced increase in striatal synapsin II expression, along with the implications of this up‐regulation in chronic haloperidol treatment, is presented.
Homosexual activity among rural Indian men: implications for HIV interventions

A cross-sectional survey of 2910 rural Indian men aged 18-40 years from five rural districts in five different states revealed that nearly 10% of single and 3% of married men had had unprotected anal sex with a man in the past year. Homosexually active men are not a separate sexual category,and report extensive mixing with female partners. They have more female partners than other men and they practised anal intercourse in 11% of their heterosexual contacts.
Sexually transmitted acute infection with a clustered genotype 4 hepatitis C virus in HIV-1-infected men and inefficacy of early antiviral therapy

Background:Recent studies have suggested an increased risk of acute hepatitis C (HCV) infection in homosexual HIV-infected men and that early treatment with standard or pegylated interferon-alfa, alone or associated with ribavirin, significantly reduces the risk of chronic evolution in HIV-infected patients. Methods:A retrospective analysis of 12 HIV-infected patients who were consecutively diagnosed as developing acute HCV infection, defined by both seroconversion of anti-HCV antibodies and detection of serum HCV RNA in those with previous negative results. Ten of these patients received early antiviral treatment with standard or pegylated interferon-alfa, alone or associated with ribavirin. Results:The only risk factor in these patients was unprotected sexual intercourse with men. Acute HCV infection was asymptomatic in 10 patients, and the HCV genotype was 4d in 10 patients. The 10 genotype 4d viruses formed a monophylogenetic group and clustered separately from other local sequences of HCV genotype 4d, suggesting a common source of infection. None of the 10 patients who were treated early with antiviral therapy had a sustained virological response, as defined by undetectable HCV RNA 6 months after therapy. Conclusions:There is a risk of sexual transmission of HCV in HIV-infected men who have sex with men; the cluster of HCV genotype 4d suggested a common source of infection and a failure in prevention counselling. Early treatment with standard interferon-alfa failed to prevent chronic evolution of HCV infection in this particular group of HIV-infected patients who had acquired this peculiar cluster of genotype 4 strains.
Comparison of corneal deformation parameters after SMILE, LASEK, and femtosecond laser-assisted LASIK.

PURPOSE To investigate the differences in corneal deformation parameters after femtosecond laser small incision lenticule extraction (SMILE), laser-assisted subepithelial keratomileusis (LASEK), and femtosecond laser-assisted LASIK (FS-LASIK). METHODS In this retrospective study, 17 eyes of 17 patients after SMILE, 18 eyes of 18 patients after LASEK, and 17 eyes of 17 patients after FS-LASIK were included. Corneal deformation parameters were measured with the CorVis ST tonometer (Oculus Optikgeräte GmbH, Wetzlar, Germany) 3 months postoperatively. RESULTS The mean value of deformation amplitude of the FS-LASIK group was significantly higher than that of the LASEK group (P = .022). The mean value of applanation time (applanation 1) of the LASEK group was significantly higher than that of the FS-LASIK group (P = .038). No significant difference was detected in the mean values of deformation amplitude and applanation time (applanation 1) (P > .05) between the LASEK and SMILE groups or between the SMILE and FS-LASIK groups. Multiple linear regression model analysis revealed that after adjustment for age and preoperative central corneal thickness and manifest refraction spherical equivalent, the significance of the difference in the mean values of applanation time (applanation 1) and deformation amplitude between the LASEK and FS-LASIK groups were P = . 084 and . 059, respectively. In all three groups, the values of applanation 1 negatively correlated to those of applanation time (applanation 2) (SMILE: r = −0.577, P = .015; LASEK: r = −0.833, P < .001; FS-LASIK: r = −0.516, P = .034) and deformation amplitude (SMILE: r = −0. 556, P = .021; LASEK: r = −0.877, P < .001; FS-LASIK: r = −0.509, P = .037). CONCLUSIONS Applanation time (applanation 1) and deformation amplitude (as measured with the CorVis ST tonometer) may be helpful in assessing corneal biomechanical changes after corneal refractive surgery. The relations between these parameters should be discussed in further studies.
Learning and teaching in clinical practice The write stuff : A proactive approach to increasing academics ' writing skills and outcomes

An important way to advance the profession of nursing, to promote best practice and to improve the quality of nursing care, is for nurses to publish. A publication track record is necessary to gain competitive research funding, build knowledge, disseminate new insights and advance the profession. However, academics often experience obstacles in publishing ranging from a pervasive teaching culture, lack of confidence in writing, and lack of strategies to write more strategically. The benefits of writing retreats have been discussed within the nursing and other academic literature but the specifics about the method as well as the unplanned benefits have not been explored. More exploration and discussion is needed about factors assisting writers to complete papers and successfully publish. This paper discusses a novel intervention which aimed to seed the beginnings of a flourishing scholarly community at a regional Queensland University. The paper also presents qualitative and quantitative evaluation data. © 2015 Elsevier Ltd. All rights reserved.
Mechanical Ventilation in Sepsis: A Reappraisal

ABSTRACT Sepsis is the main cause of close to 70% of all cases of acute respiratory distress syndromes (ARDS). In addition, sepsis increases susceptibility to ventilator-induced lung injury. Therefore, the development of a ventilatory strategy that can achieve adequate oxygenation without injuring the lungs is highly sought after for patients with acute infection and represents an important therapeutic window to improve patient care. Suboptimal ventilatory settings cannot only harm the lung, but may also contribute to the cascade of organ failure in sepsis due to organ crosstalk. Despite the prominent role of sepsis as a cause for lung injury, most of the studies that addressed mechanical ventilation strategies in ARDS did not specifically assess sepsis-related ARDS patients. Consequently, most of the recommendations regarding mechanical ventilation in sepsis patients are derived from ARDS trials that included multiple clinical diagnoses. While there have been important improvements in general ventilatory management that should apply to all critically ill patients, sepsis-related lung injury might still have particularities that could influence bedside management. After revisiting the interplay between sepsis and ventilation-induced lung injury, this review will reappraise the evidence for the major components of the lung protective ventilation strategy, emphasizing the particularities of sepsis-related acute lung injury.
Education and the minimum wage in the United States

ABSTRACT This article shows that, across the US states, the level of education has a causal effect on the minimum wage. More specifically, it argues that a one-percentage point increase in the proportion of college graduates implies a 0.4–0.5% decrease in the real value of the minimum wage. This is the first article that uses System GMM in order to examine the effect of education on the minimum wage. Given the structure of the available data, this is the most appropriate econometric technique. System GMM not only controls for endogeneity and for fixed effects but also maximizes the precision of the estimates by using all the available variation in the data.
Impact of Glycemic Variability on Chromatin Remodeling, Oxidative Stress, and Endothelial Dysfunction in Patients With Type 2 Diabetes and With Target HbA1c Levels

Intensive glycemic control (IGC) targeting HbA1c fails to show an unequivocal reduction of macrovascular complications in type 2 diabetes (T2D); however, the underlying mechanisms remain elusive. Epigenetic changes are emerging as important mediators of cardiovascular damage and may play a role in this setting. This study investigated whether epigenetic regulation of the adaptor protein p66Shc, a key driver of mitochondrial oxidative stress, contributes to persistent vascular dysfunction in patients with T2D despite IGC. Thirty-nine patients with uncontrolled T2D (HbA1c >7.5%) and 24 age- and sex-matched healthy control subjects were consecutively enrolled. IGC was implemented for 6 months in patients with T2D to achieve a target HbA1c of ≤7.0%. Brachial artery flow-mediated dilation (FMD), urinary 8-isoprostaglandin F2α (8-isoPGF2α), and epigenetic regulation of p66Shc were assessed at baseline and follow-up. Continuous glucose monitoring was performed to determine the mean amplitude of glycemic excursion (MAGE) and postprandial incremental area under the curve (AUCpp). At baseline, patients with T2D showed impaired FMD, increased urinary 8-isoPGF2α, and p66Shc upregulation in circulating monocytes compared with control subjects. FMD, 8-isoPGF2α, and p66Shc expression were not affected by IGC. DNA hypomethylation and histone 3 acetylation were found on the p66Shc promoter of patients with T2D, and IGC did not change such adverse epigenetic remodeling. Persistent downregulation of methyltransferase DNMT3b and deacetylase SIRT1 may explain the observed p66Shc-related epigenetic changes. MAGE and AUCpp but not HbA1c were independently associated with the altered epigenetic profile on the p66Shc promoter. Hence, glucose fluctuations contribute to chromatin remodeling and may explain persistent vascular dysfunction in patients with T2D with target HbA1c levels.