Miracle-dz/UniFAR-FTUs huggingface dataset:
Cell Stem Cell ABCA 1 , ABCG 1 , and HDL Regulate HSPC

Marit Westerterp,1,2,6 Samuel Gourion-Arsiquaud,3,4,6 Andrew J. Murphy,1,6 Alan Shih,5 Serge Cremers,1 Ross L. Levine,5 Alan R. Tall,1,7 and Laurent Yvan-Charvet1,7,* 1Department of Medicine, Division of Molecular Medicine, Columbia University, New York, NY 10032, USA 2Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam 1105 AZ, The Netherlands 3Hospital for Special Surgery, New York, NY 10021, USA 4TRI/Princeton, Princeton, NJ 08542, USA 5Human Oncology and Pathogenesis Program and the Leukemia Service, Department of Medicine Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA 6These authors contributed equally to this work 7These authors contributed equally to this work *Correspondence: ly2159@columbia.edu http://dx.doi. org/10.1016/j.stem. 2012.04. 024
Hybrid Geoinformatic-Statistical Analysis for Assessing Single-Family-Home Values: The Case of College Station, Texas

This study investigates the impact of certain residential development elements on the value of single-family homes (SFH) within an urban setting. Development elements such as gatedness, level of amenity, and size and proximity of nearest city-park were investigated. Appraisals of SFH in the City of College Station, Texas; and market values and other SFH's multiple listing services data for approximately 1326 randomly distributed SFH's are utilized as the database for this study. The methodology of this research integrates traditional econometric techniques used in value analysis, namely the hedonic price function, with cutting edge geoinformatic technology. Automated spatial analy- sis tools offered efficient and accurate generation, validation, manip- ulation, and assessment of development variables. Furthermore, resolution of spatial autocorrelation encountered in statistical analysis was facilitated using residual mapping processes along with tradi- tional residual plots and other statistical remedies. Findings indicate that the power of the hybrid geoinformatic- statistical model in analyzing, explaining, and presenting change in real estate value is significant. Furthermore, findings indicate that gated ness of a development has a higher positive impact on home values in such a development than the level of amenities provided, e.g. trails, playgrounds, common greens, etc.
Thermal Radiation Effects on MHD Fluid Flow Near Stagnation Point of Linear Stretching Sheet with Variable Thermal Conductivity

Aim of the paper is to investigate effects of variable thermal conductivity and heat source/sink on steady two-dimensional radiative MHD boundary-layer flow of a viscous, incompressible, electrically conducting fluid in the presence of variable free stream near a stagnation point on a non-conducting stretching sheet. The equations of continuity, momentum and energy are transformed into ordinary differential equations and solved numerically using shooting method. The velocity and temperature distributions are discussed numerically and presented through graphs. Skin-friction coefficient and the Nusselt number at the sheet are derived, discussed numerically and their numerical values for various values of physical parameters are presented through Tables.
THE DISCOVERY OF SEVEN EXTREMELY LOW SURFACE BRIGHTNESS GALAXIES IN THE FIELD OF THE NEARBY SPIRAL GALAXY M101

Dwarf satellite galaxies are a key probe of dark matter and of galaxy formation on small scales and of the dark matter halo masses of their central galaxies. They have very low surface brightness, which makes it difficult to identify and study them outside of the Local Group. We used a low surface brightness-optimized telescope, the Dragonfly Telephoto Array, to search for dwarf galaxies in the field of the massive spiral galaxy M101. We identify seven large, low surface brightness objects in this field, with effective radii of 10–30 arcseconds and central surface brightnesses of μg ∼ 25.5–27.5 mag arcsec−2. Given their large apparent sizes and low surface brightnesses, these objects would likely be missed by standard galaxy searches in deep fields. Assuming the galaxies are dwarf satellites of M101, their absolute magnitudes are in the range −11.6 ≲ MV ≲ −9.3 and their effective radii are 350 pc–1.3 kpc. Their radial surface brightness profiles are well fit by Sersic profiles with a very low Sersic index (n ∼ 0.3–0.7). The properties of the sample are similar to those of well-studied dwarf galaxies in the Local Group, such as Sextans I and Phoenix. Distance measurements are required to determine whether these galaxies are in fact associated with M101 or are in its foreground or background.
Transport of peritoneal membrane assessed before and after the start of peritoneal dialysis

Background. Haemodialysis (HD) and peritoneal dialysis (PD) should be regarded as complementary methods of renal replacement therapy. Approximately 10–20% of patients on PD are transferred annually to HD due to technique failure. Much smaller proportion of patients changes modality from HD to PD, predominantly due to vascular access problems, cardiac disease or patient preference. The effects of these transfers on therapy outcome, patient and technique survival have not been studied, with research focusing on outcome measures within the single modality and comparisons between the two methods. Methods. We have analysed retrospectively a cohort of 264 patients treated with PD in a single PD centre during 1994–2006. Patient characteristics, therapy measures and outcome of patients were compared between patients for whom PD was the initial method of renal replacement therapy (group 1, n = 197) and those transferred to PD from haemodialysis because of complications (group 2, n = 67). The Kaplan–Meier method and Cox proportional hazards multiple regression analysis were used to assess patient and technique survival. Results. In patients transferred from HD, significantly less had diabetes (11.9% versus 38.1%, P < 0.0001) and there were also significantly more females (57% versus 42.2%, P < 0.05). Baseline Kt/V was significantly higher in the primary PD therapy group (2.46 ± 0.57 versus 2.11 ± 0.48, P < 0.001), due to lower residual renal function in patients transferred from HD. Group 2 had also significantly higher peritonitis rate (0.86 versus 0.62 episode/year, P < 0.05). During the time of observation, 71 patients have died, in 100 patients kidney transplantation was performed, 56 were transferred to HD, renal function recovered in 5 and 32 were still on PD at the end of the study. No significant differences were observed in unadjusted patient survival, but technique survival was significantly lower in group 2 (P < 0.05). In the Cox multiple regression model, diabetes status, age and albumin level significantly influenced survival. Relative risk of death was not increased significantly in patients transferred from HD. Conclusions. Our data suggest that outcome of patients transferred from HD is similar to that achieved in patients in whom PD is the first choice therapy. Thus, this option should be strongly considered in patients experiencing complications on HD, mainly vascular access problems, heart failure or intradialytic hypotension.
Mutual fund investment horizon and performance

This paper proposes several new holdings-based measures of fund investment horizon, and examines the relation between manager skills and fund holding horizon. We find that both aggregate holdings and trades of long-horizon funds are informative about superior future long-term stock returns, whereas aggregate trades, but not holdings, of short-horizon funds are associated with future short-term stock returns. Specifically, stocks that are largely held by long-term funds outperform stocks that are largely held by short-term funds by roughly 3% per year over the following five-year period. This superior performance of fund managers with long investment horizons stems from their ability to identify superior long-term firm fundamentals. In contrast, short-term funds predict short-term earnings or use simple mechanical strategies, such as momentum strategies, to select stocks.
Active Comb Filter Using Operational Transconductance Amplifier

A new approach for the design of an active comb filter is proposed to remove the selected frequencies of various signals. The proposed filter is based on only OTAs and capacitors, hence suitable for monolithic integrated circuit implementation. The workability of the circuit is tested using PSPICE for test signals of 60, 180, 300, and 420 Hz as in ECG signal. The results are given in the paper and found to agree well with theory.
Evaluation of Bacillus subtilis and Lactobacillus acidophilus probiotic supplementation on reproductive performance and noxious gas emission in sows

Abstract The impacts of probiotics supplementation on reproduction performance and noxious gas emission in sows was evaluated in an experiment with a total of thirty sows (second-parity), from 4 weeks prior to farrowing, to day 21 of lactation. The gestation and lactation diets of sows were supplemented with probiotics containing Bacillus subtilis (1.2 × 107 cfu/g) and Lactobacillus acidophilus (1.15 × 106 cfu/g). Treatment included: basal diet (CON), basal diet + 0.1% probiotics (PB0.1), and basal diet + 0.2% probiotics (PB0.2). The supplementation of dietary probiotics significantly improved average daily feed intake during the lactation period (quadratic, P = 0.0429), sow backfat thickness during the weaning period (linear, P = 0.0385), and initial body weight of piglets (linear, P = 0.0054) as compared with CON, respectively. Furthermore, the supplementation of dietary probiotics reduced noxious gas emission as compared with CON (linear, P<0.05 for day 5 and day 10), respectively. In conclusion, dietary probiotics containing B. subtilis and L. acidophilus improved the growth performance of sows, resulted in increased weaning body weight of piglets, and induced an effective and significant reduction in fecal noxious gas emission in lactating sows, as compared with CON.
rimary angioplasty : Effect of deferred tenting on stent size ngioplastie primaire : impact de la stratégie de stenting différé sur la taille u stent

a Cardiology Department, European Society of Hypertension Excellence Center, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, 69004 Lyon, France b Université de Lyon, CREATIS, CNRS UMR5220, INSERM U1044, INSA-Lyon, Université Claude-Bernard Lyon 1, Hospices Civils de Lyon, 69100 Lyon, France c Université d’Auvergne, Cardio-Vascular Interventional Therapy and Imaging, Image Science for Interventional Techniques, UMR 6284, 63000 Clermont-Ferrand, France d University Hospital of Clermont-Ferrand, Cardiology Department, 63000 Clermont-Ferrand, France
revalence and correlates of non-optimal econdary medical prevention in patients ith stable coronary artery disease révalence et déterminants d ’ une prévention secondaire non optimale en cas e maladie coronaire stable

a Polyclinique du Bois, Lille, France b Centre Hospitalier de Dunkerque, Dunkerque, France c Centre Hospitalier Régional et Universitaire de Lille, Lille, France d Inserm U744, Institut Pasteur de Lille, Université Lille Nord de France, Lille, France e Faculté de Médecine de Lille, Lille, France f Polyclinique de Riaumont, Lievin, France g Centre Hospitalier de Lens, Lens, France h Centre Hospitalier de Seclin, Seclin, France i Medical Office, Templemars, France j Medical Office, Somain, France k Centre Hospitalier de Wattrelos, Wattrelos, France l Clinique des Acacias, Cucq, France m Centre Hospitalier de Boulogne-sur-mer, Boulogne-sur-mer, France n Medical Office, Henin Beaumont, France
Children's mappings of part-whole construct of fractions

The representation of part-whole relations that are embodied in fractional numbers continues to be a problematic area of learning for many children. In this study I examine this problem with a ten-year old child by analyzing his mappings between the language of fractions, area models and symbols. The visual models in this study were built and modified with computer manipulatives called Javabars. Results of analysis showed that the participant experienced difficulty in mapping symbolic representation of selected fractions to the area analogs.
Probiotics and Oxidative Stress

A large number of reports about the health benefits of probiotics could be found in the PubMed database. Very little information is available about probiotics possessing physiologically relevant antioxidative properties. Quite scarce is information on the influence of probiotics on human body oxidative stress status and a limited number of clinical trials have been conducted on the effect of antioxidative lactic acid bacteria on human oxidative stressdriven cardiovascular disease-related aspects. In this chapter possibilities of antioxidative probiotics to influence on oxidative stress status in human body are discussed.
Evaluating the effects of different fractions obtained from Gundelia tournefortii extract against carbon tetrachloride-induced liver injury in rats

Xenobiotics-induced liver injury is a major challenge for clinicians and pharmaceutical industry. Hence, finding new therapeutic molecules against this complication has clinical value. The current investigation aimed to evaluate the potential protective effects of different fractions obtained from Gundelia tournefortii (GT) hydroalcoholic extract in a rat model of acute hepatic injury. Male Sprague-Dawley rats (200‑250 g) were treated with carbon tetrachloride (CCl4) (1.5 ml/kg, i.p), then ethanol, water, chloroform, ethyl acetate, and n-Butanol fractions of GT extract were administered. Biochemical and histopathological markers of hepatic injury were assessed and glutathione (GSH) and lipid peroxidation were monitored in liver samples. CCl4 administration caused hepatotoxicity as revealed by an increase in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) activity, as well as pathological changes of the liver. Furthermore, a significant reduction in hepatic glutathione content and an elevation in lipid peroxidation were observed in CCl4‑treated rats. It was found that the n‑butanol (200 mg/kg) and the ethyl acetate (300 mg/kg) fractions of GT extract protected liver against CCL4‑induced damage as judged by lower AST, ALT, LDH and lipid peroxidation, prevention of tissue glutathione depletion, and alleviation of histopathological damages of liver in extract‑treated animals. As n‑butanol and the ethyl acetate fractions of GT effectively alleviated the liver injury induced by CCl4 and provide antioxidant properties, we might be able to propose that the hepatoprotective chemicals of Gundelia extract are present in these fractions.
serine protease inhibitor , is renoprotective by Pigment epithelium-derived factor , a noninhibitory inhibiting the Wnt pathway

inhibiting the Wnt pathway Xuemin He, Rui Cheng, Kyoungmin Park, Siribhinya Benyajati, Gennadiy Moiseyev, Chengyi Sun, Lorin E. Olson, Yanhui Yang, Bonnie K. Eby, Kai Lau and Jian-xing Ma Department of Physiology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA; Joslin Diabetes Center, Harvard Medical School, Harvard University, Boston, Massachusetts, USA; Department of Cell Biology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA; Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA; Key Laboratory of Hormones and Development, Tianjin Metabolic Diseases Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China; and Section of Nephrology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
Dynamics of soluble extracellular polymeric ­substances and transparent exopolymer particle pools in coastal ecosystems

Time series of soluble extracellular polymeric substance (S-EPS) and transparent exopolymer particle (TEP) fractions, as well as biological, physical and chemical parameters, were studied in natural phytoplankton assemblages at 2 macrotidal sites located in the English Channel for 3 yr. The first site, the Bay des Veys (BDV), is sheltered from prevailing winds and influenced by a high river discharge, whereas the second, Lingreville-sur Mer (LGV), is exposed to the open ocean and to dominant winds. At both sites, the highest TEP concentrations were measured in spring and summer (1735 and 3604 µg equiv X l -1 at BDV and LGV, respectively) and were correlated with phytoplankton biomass and nitrogen concentrations. During the autumn and winter, TEP dynamics were not related to phytoplankton dynamics but appeared controlled by hydrodynamics. In contrast to TEP concentrations, S-EPS did not present any seasonal dynamics and was not correlated with TEP variations. The highest amount of S-EPS was recorded in spring at LGV (25.8 mg equiv. glucose l -1 ) and in summer at BDV (26.4 mg equiv. glucose l -1 ). The S-EPS pool was separated in 2 fractions according to the molecular weight: low (LW) and high (HW). The LW fraction was produced in higher quantity than the HW fraction, and with larger temporal fluctuations. Therefore, both S-EPS fractions seem controlled by different environmental parameters depending on the season and on the studied ecosystem. The different dynamics observed for TEP and S-EPS confirm the complexity of carbon excretion processes in phytoplankton, and the results reveal different metabolic pathways and differ- ent origins for these carbon excretions.
Prevalence of Hypertension and Diabetes Mellitus Among Individuals Attending a Health Fair in Dominica

Hypertension and Diabetes mellitus stands out to be one of the major diseases recorded worldwide. This has led to various responses by several organisations aiming at reducing and managing the incidence of these illnesses. Despite active involvement in combating hypertension and diabetes mellitus, recent surveys have also shown an incidence of over 1 billion hypertension cases and approximately 366 million diabetic individuals. Incidence of these diseases among the Caribbean populace have also shown similar increase, although surveys done among Caribbean islands in respect to the prevalence of hypertension and diabetes mellitus are limited. Thus this study is aimed at identifying cases of hypertensive and diabetic individuals in Dominica during a health fair. A total of 146 subjects were examined based on questionnaire and vital signs examination. Aside other parameters checked, 85(58.22%) and 47(33.58%) presented with high blood pressure and high blood glucose respectively. This study therefore highlights the need for proper awareness on the risks and complications of hypertension and diabetes mellitus among Caribbean indigene.
Stable isotope ratios and contaminant concentrations in a sewage-distorted food web

Concentrations of selected neutral organic contamlnants and stable isotope ratios of carbon nltrogen and deu tenudhydrogen In invertebrates and fish were compared from near a large, 60m deep municipal waste outfall near Los Angeles Cahforn~a, where waste has a measurable influence on the structure of the marlne food web, and from a reference area off Santa Barbara, Cahfomia Oblect~ves were to investigate (1) the degree of utilization of sewage organlc matter in the food web especially by 3 species of fish, (2) l f ferences in contaminant accumulahon between these benthophagous fish and (3) the behavior of organic contamlnants relat~ve to each other and to organlc matter through several t rophc levels Isotopically lighter carbon and nitrogen and h g h e r concentrations of most chlorinated hydrocarbons were found in t~ssues of organisms from near the outfall On the basis of the 6I3C and 6I5N of the fishes, the estimated contnbution of nitrogen and carbon from sewage was about 15 to 20% of their requirements for these elements The 613c and 6 1 5 ~ values increased in the fishes In the order of M~crostomus paclficus, Clthanchthys sordldus and Zaruolep~s lahplnnls The Cs/K rat10 of the latter species was also sign~ficantly h ~ g h e r than the former 2 species also ind~cahng its h g h e r t roph~c posihon C sordldus had the highest wet-weight concentrations of chlonnated hydrocarbons and phthahc a c ~ d esters, intermed~ate concentrat~ons of these compounds were found in Z lahplnnls and the lowest concentrations were found In M paclficus Concentrations of chlonnated hydrocarbons on a 11pid-weight basis changed this order so that ~t more closely resembled the t roph~c structure revealed by the stable isotope ratio and Cs/K rat10 data Increases of both XDDT and Aroclor 1254, from deposit-feeding invertebrates through fish were evldent In foodwebs of the outfall and reference areas as posit~ve correlations w t h 6I3C A large degree of correlahon was evldent between contaminants in Z lahpinnls but not in the other 2 fish species These correlations were apparently not a function of liver lipid concentration, but the strengths of the correlations were dependent on the similarities of log KO, values of the correlated compounds
Effect of Pack-Year of Cigarette Smoking on Erythrocyte Parameters and Glucose Level Among Healthy Males

Objective: To evaluate the effect of cigarette smoking and pack-year of cigarette smoking on red blood cell counts and its related parameters, also glucose concentration. Methods: Sixty consenting subjects of which 30controls (non-smokers) and 30 cases (smokers) were studied. Smokers were divided into two groups based on pack-year of cigarettes smoked. The red blood cell parameters and glucose level were analyzed in smoker and non-smoker. Independent T-test was used to comparison of a smoker and also one way ANOVA was used to comparison pack-year of smoking groups. Results: The present study showed no changes significantly in red blood cell parameter and glucose level between in smoker. The current result appeared alteration of red blood cells counts (RBC), hemoglobin level (HGB), hematocrit percent (HCT) and mean corpuscular hemoglobin concentration level (MCHC), while no difference of mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), red cell distribution width (RDW) and glucose level in duration of smoking. Conclusions: This study revealed that cigarette smoking statistically no effect on RBC counts and its related parameters and glucose level among healthy. However, the duration of smoking statistically had the effect on RBC, HGB, HCT and MCHC while had no effect on MCV, MCH, RDW and glucose level.
A public health approach to enhancing safe and supportive family environments for children

Families are the mainstay of safety and support for children's positive development (Bowes, Watson, and Pearson, 2009). Although families can be the source of harm (e.g., from child abuse, neglect or exposure to domestic violence), they can also be the most important source of protection from harm for children when they provide a sense of security, foster self-esteem and respond appropriately to children's needs.