Miracle-dz/UniFAR-FTUs huggingface dataset:
Self-Management of Older Adolescents with Inflammatory Bowel Disease: A Pilot Study of Behavior and Knowledge as Prelude to Transition

Objective: Patients gradually assume responsibility for self-management. This study sought to determine whether adolescents with inflammatory bowel disease (IBD) have developed key skills of self-management prior to the age at which many transfer to adult care. Patients and Methods: Adolescents aged 16 to 18 years old in the Children’s Hospital Boston IBD database (94 total) received a mailed survey assessing knowledge and confidence of their own health information and behaviors. Results: Respondents (43%) could name medication and dose with confidence but had very poor knowledge of important side effects. Most patients deferred responsibility mostly or completely to parents for scheduling appointments (85%), requesting refills (75%), or contacting provider between visits (74%). Conclusions: Older adolescents with IBD have good recall of medications but not of side effects. Parents remain responsible for the majority of tasks related to clinic visits and the acquisition of medications.
Eye Movements , Strabismus , Amblyopia , and Neuro-Ophthalmology Noninvasive Assessments of Optic Nerve Neurodegeneration in Transgenic Mice With Isolated Optic Neuritis

Citation: Talla V, Yang C, Shaw G, Porciatti V, Koilkonda RD, Guy J. Noninvasive assessments of optic nerve neurodegeneration in transgenic mice with isolated optic neuritis. Invest Ophthalmol Vis Sci. 2013;54:4440–4450. DOI:10.1167/ iovs.13-11899 PURPOSE. To determine if phosphorylated neurofilament heavy chain (pNF-H) released into the bloodstream and the pattern ERG are noninvasive indicators of neurodegeneration in experimental optic neuritis.
Seasonal variation in male alternative reproductive tactics

Genetic parentage analyses reveal considerable diversity in alternative reproductive behaviours (e.g. sneaking) in many taxa. However, little is known about whether these behaviours vary seasonally and between populations. Here, we investigate seasonal variation in male reproductive behaviours in a population of two‐spotted gobies (Gobiusculus flavescens) in Norway. Male two‐spotted gobies guard nests, attract females and care for fertilized eggs. We collected clutches and nest‐guarding males early and late in the breeding season in artificial nests and used microsatellite markers to reconstruct parentage from a subset of offspring from each nest. We hypothesized that mating, reproductive success and sneaking should be more prevalent early in the breeding season when competition for mates among males is predicted to be higher. However, parentage analyses revealed similar values of mating, reproductive success and high frequencies of successful sneaking early (30% of nests) and late (27% of nests) in the season. We also found that multiple females with eggs in the same nest were fertilized by one or more sneaker males, indicating that some males in this population engage in a satellite strategy. We contrast our results to previous work that demonstrates low levels of cuckoldry in a population in Sweden. Our results demonstrate marked stability in both the genetic mating system and male alternative reproductive tactics over the breeding season. However, sneaking rates may vary geographically within a species, likely due to local selection influencing ecological factors encountered at different locations.
The brand loyalty of sportswear in Hong Kong

This paper reports the results of brand loyalty of 280 university students, aged from 18 to 24 years old. This study explores brand loyalty behavior on sportswear and examines key brand loyalty factors: brand name, product quality, price, style, store environment, promotion, and service quality. Consumers are classified into two categories by their degree on brand loyalty: hard-core loyal consumers and brand switchers. The study concludes that brand name, style, and promotion are the key brand factors which can distinguish hard-core loyal consumers and brand switchers. Brand name and style have more influence on the brand loyalty of hard-core loyal consumers, while promotion influences more on that of brand switchers. Product quality is perceived by both groups as the most important factor affecting their brand loyalty.
Female-Owned Micro-Enterprises and Quality of Services of Susu Collectors : A Perceptual Perspective

We examine the perception of female-owned micro-enterprises in the fishing industry as regards the quality of services of susu collectors. We also investigate the quality dimensions of susu services. We hypothesize that susu service quality influences overall customer satisfaction, customer loyalty and customer networking. We add that overall customer satisfaction leads to customer loyalty. Based on a sample of 1203 female-owned micro-enterprises in the fishing industry, our findings support these arguments. Also, the most important susu service quality dimensions are tangibility and empathy. This study contributes to the service quality literature as though the five susu quality dimensions obtained confirm the original dimensions of SERVQUAL/SERVPERF models, the debate on the number of dimensions is still inconclusive as this study is done in the informal banking industry. Also, how these five susu dimensions relate to overall customer satisfaction, customer loyalty and customer networking as well as how overall satisfaction influences loyalty of female micro-enterprises in the fishing industry. We draw conclusion and discuss implications for managers.
Kudoa cerebralis sp. n. (Myxosporidea, Chloromyxidae) from the striped bass, Morone saxatilis (Walbaum).

SYNOPSIS Kudoa cerebralis sp. n. is described from connective tissue of the nervous system in the striped bass, Morone saxatilis (Walbaum), from the southern Chesapeake Bay area. This is the first time the genus Kudoa has been found in association with the nervous system. The polar view mean diameter of the spores was 7.0 μm and the polar capsule mean length was 3.7 μm.
Celiac disease diagnosis without endoscopy: is it really effective among screened patients?

T o the Editor: I read with great interest the article by Webb et al (1) concerning the applicability of the new European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for celiac disease (CD) among screened patients. The authors conclude that by adapting the revised criteria, biopsies could have been omitted in one-fourth of all of the cases of screened children. These data are supported by a large population. Nevertheless, Barnea et al (2) confirm that patients lost at follow-up are generally those who are diagnosed at a later age and who are not involved in well organized serological and clinical control programs. Webb et al (3) stated in another article that adolescents diagnosed through screening show good adherence to the gluten-free diet after 1-year follow-up. These data, although controversial, show that the objective should be an early diagnosis and that patients should be fully informed about the extent of the disease, the reason for a strict and lasting gluten-free diet and the possibility of complications related to nonadherence. Screening programs for CD, while remaining effective and useful diagnostic tools, if deprived of endoscopic examination through the adoption of the new guidelines, cannot be effective in giving the patient the right awareness of the disease and the real need of dietary therapy. A total absence of symptoms associated with a not laborious diagnosis prove to be in contrast to a challenging diet and difficult to maintain. In this way, the risk is to make useless the very purpose of the screening program.
Interrelationship between milk constituents, serum oestradiol and vaginal mucus indicators of oestrus in Egyptian buffaloes.

The intensity of heat signs in buffaloes is generally low and the incidence of suboestrus varied from 15 to 73% (Buffalopedia). The objective of this study was to investigate the feasibility of monitoring the changes in some milk constituents, oestradiol levels and electrical conductivity of vaginal mucus during peri-oestrous period in prediction of the timing of oestrus in buffaloes. Twenty-one Egyptian buffaloes aged 3-9 year, 1st-6th lactations, were examined by oestrous detector and ultrasonographically for monitoring the ovarian and uterine activity for 7 days around the time of standing oestrus. Sodium, potassium, chloride and lactose were assayed in aqueous phase of milk; besides, oestradiol was estimated in serum. Current results declared highly significant acute changes in milk constituents at the time of oestrus characterized by peaking of chloride and sodium levels and lowering of potassium and lactose values. The alternation in milk composition when arranged in decreasing order of magnitude, sodium was the highest (77.78 ± 0.69%), followed by chloride (61.60 ± 1.52%) and potassium (-58.14 ± 10.89%). Concomitantly, milk lactose decreased by 26.07 ± 7.97% compared to baseline levels. Synchronously, vaginal electrical resistance (VER) showed a significant (p < 0.01) decrease, but serum oestradiol 17β levels surged (59.93 ± 7.29 pg/ml) on day of oestrus. Serum oestradiol level was negatively correlated with VER (r = -0.577), potassium (r = -0.661), positively correlated with chloride (r = 0.707) and sodium (r = 0.579) and not correlated with lactose levels. These results for the first time suggested that the changes in constituents of milk during peri-oestrous period may be used as a practical non-invasive indicator for oestrous detection and prediction of ovulation in Egyptian buffaloes.
Characterization of the Vacuolar Transporters for Amino Acid Recycling in Yeast Autophagy

Autophagy is induced in response to nitrogen starvation and delivers bulk of cytosolic proteins to the vacuole to degrade them. Amino acids generated in vacuoles by autophagy are recycled for survival in nitrogenstarved condition. Recently, various physiological roles of autophagy have been revealed. Studies on the marine mussel, Mytilus edulis, demonstrated that autophagy facilitates the recovery of digestive gland from environmentallyinduced oxidative stress. It is inferred that autophagy removes oxidatively and pollutant damaged proteins. We here examined the genes for the amino acid recycling process in autophagy. In yeast Saccharomyces cerevisiae, three transporters have been demonstrated to involve in export of amino acids from vacuoles. Both Avt3 and Avt4 export neutral amino acids and Avt6 exports acidic amino acids. We found that the deletion of AVT6 gene resulted in the loss of survivability and the increase of vacuolar glutamate concentration especially in response to nitrogen starvation. In addition, the cellular amount of Avt6Myc9 protein increased upon nitrogen starvation. These suggest that Avt6 functions in the recycling process of amino acids in autophagy. In addition, we examined the expression and subcellular localization of Avt5 and Avt7, which are closely related to Avt6, and found the distinct characteristics of these proteins.
Decisions With Multiple Objectives Preferences And Value Tradeoffs

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Lung Uptake of Lidocaine in Man as Influenced by Anaesthesia, Mepivacaine Infusion or Lung Insufficiency

Pulmonary uptake of lidocaine was investigated in patients before surgery, and aimed at elucidating the influence of general anaesthesia, the presence of another local anaesthetic agent in the blood, or the possible impact of lung insufficiency. When the lung uptake of lidocaine, injected as a bolus together with indocyanine green dye, was calculated as uptake at 95% pass of the dye, there were no statistically significant differences between the four groups. When the extraction in each of the arterial blood samples was calculated on the basis of the relation between relative concentrations, there were statistically significant differences, with a general tendency towards higher extraction of lidocaine in the awake, healthy volunteers, not given mepivacaine, compared to the other groups. In the group in whom mepivacaine was infused, the arterial concentration of mepivacaine increased transiently after the injection of lidocaine. This probably reflects a displacement of mepivacaine from binding sites for both agents. From this study, it is postulated that the ability of the pulmonary circulation to clear the blood of lidocaine is high, and that it is not affected markedly by those situations studied in the present investigation.
Domestic violence screening and referral can be effective.

STUDY OBJECTIVE We provide a targeted intervention in the emergency department for intimate partner violence (IPV) victims and to facilitate follow-up care from a professional case manager. METHODS This observational case study was conducted in an urban ED from July 1, 1997, through December 31, 1999. The targeted population consisted of all English-speaking women between the ages of 18 and 65 years presenting 24 hours a day, 7 days a week. There were 3 components to the study. The first consisted of an effort to improve the screening for IPV of female patients seen in the ED. The primary outcome for this component was the correlation of increased screening rates with increased violence detection. Universal screening of all women for IPV regardless of their chief complaint was encouraged through an IPV script and a new reporting area on the nursing note. The second component was an on-site IPV advocacy intervention. Once IPV was identified by means of screening or self-disclosure, the nurse notified a volunteer advocate from a local human service agency, who came to the ED within 30 minutes, conducted a crisis intervention, and encouraged the patient to follow-up with the case manager. The outcomes were patient cooperation with the ED intervention and subsequent follow-up with the community-based agency. The third phase was telephone-based counseling by an IPV case manager to help the client reduce her exposure to additional violence. The outcome was the client's self-report of a life free of violence. RESULTS Of the 528 women identified as IPV victims, 475 (84%) agreed to speak to the advocate, and 258 (54% of those seen by the advocate) accepted case management follow-up. After the case management process, lasting 3 to 6 weeks, 127 women reported that they no longer believed they were at risk for violence from their abuser. CONCLUSION Through a coordinated effort by the medical staff and the volunteer advocates, 258 of 528 IPV victims seen in the ED received ongoing community-based services to address their experience of IPV.
Prodomain mutations at the subtilisin interface: correlation of binding energy and the rate of catalyzed folding.

The in vivo folding of subtilisin is dependent on a 77 amino acid prosequence, which is eventually cleaved from the N-terminus of subtilisin to create the 275 amino acid mature form of the enzyme. The recent determination of the structure of a complex of the prodomain and a calcium-free subtilisin mutant has suggested how the prodomain may catalyze subtilisin folding [Bryan, P., Wang, L. , Hoskins, J., Ruvinov, S. , Strausberg, S. , Alexander, P., Almog, O. , Gilliland, G. , & Gallagher, T. (1995) Biochemistry 34, 10310-10318]. In the complex, the prodomain packs against the two parallel surface helices of subtilisin (residues 104-116 and residues 133-144) and supplies caps to the N-termini of the two helices. The binding site is contained almost entirely in the linear sequence 100-144 of subtilisin. The C-terminus of the prodomain (residues 72-77) extends out from its central part to bind like a substrate in subtilisin's active site cleft. The simplest model of catalyzed folding is one in which the observed binding interaction in the complex accelerates folding by stabilizing an intermediate which includes the 45 amino acid alpha beta alpha substructure in subtilisin. According to our hypothesis, amino acids 100-144 would have a native-like fold in the intermediate which the prodomain stabilizes. Guided by the structure of the bimolecular complex of subtilisin and its prodomain, we have constructed mutations in the C-terminal region of the prodomain. Analysis of five mutants reveals a general correlation between the ability of the prodomain to bind to native subtilisin and its ability to accelerate subtilisin folding. (ABSTRACT TRUNCATED AT 250 WORDS)
The risk of cytomegalovirus recurrence after kidney transplantation

Recurrent cytomegalovirus (CMV) infections commonly occur after kidney transplantation. We studied the impact of secondary prophylaxis and other factors on the risk of CMV recurrence. All kidney transplant recipients between 2004 and 2009 in our institution were analyzed (N = 254). Patients with CMV infection were included (N = 62). CMV infections were diagnosed with quantitative PCR. CMV D+/R− recipients received 6 months valganciclovir prophylaxis, after which DNAemia was monitored. After treatment, secondary prophylaxis with valganciclovir was given at the clinician’s discretion for 2–26 weeks and CMV DNAemia was monitored. Altogether 43 reactivations and 19 primary infections occurred. Antiviral treatment with valganciclovir or ganciclovir was given to 45 patients; 34/62 (55%) patients received secondary prophylaxis for mean 62 days (range 14–180 days). CMV recurrence occurred in 14/43 (33%) seropositive patients and in 4/19 (21%) patients after primary infection. In logistic regression, delayed graft function (OR 3.4) and high viral load (>100 000 copies/ml) at initial diagnosis (OR 5.9) predicted recurrence. Use or length of secondary prophylaxis, CMV serostatus, level of immunosuppression, HLA mismatch, antiviral treatment, or time to clearance of viremia during treatment did not predict recurrence of CMV. CMV recurrences occur commonly despite secondary prophylaxis. High viral load at diagnosis predicted the risk of recurrent CMV infection.
Intravital video‐capillaroscopy for the study of the microcirculation in psoriasis

Intravital capillaroscopy using a video‐microscopy system permits real‐time imaging of the skin microvasculature with retrospective analysis of capillary dynamics. The addition of fluorescein angiography improves contrast and detects aspects of blood vessel behaviour, such as perfusion homogeneity and transcapillary solute diffusion, not detectable under native conditions. This study was performed to evaluate whether the method can be applied to the investigation of a skin disease and in particular the understanding of the role of the blood vessel in the pathogenesis of psoriasis. Results demonstrated clear differences between normal and psoriatic skin. More capillaries were red cell perfused in both plaque and uninvolved skin compared to normal skin (P<0·001 and 0·01 > P<0·02. respectively). The capillaries in psoriatic plaque skin were much larger than those in normal skin (P<0·001). The density of capillaries was not increased in plaque or uninvolved psoriatic skin, indicating expansion of existing vessels and not new vessel formation. The area of fluorescence seen around each capillary at 60 s was greater in plaque (P < 0·001) and in uninvolved psoriatic skin (P< 0·001) than in normal skin, indicating greater vessel transcapillary diffusion. This study confirms the value of video‐microscopy as a non‐invasive technique for the examination of the cutaneous microcirculation in vivo.
Background Modeling to Detect Foreground Objects Based on ANN and Spatio-Temporal Analysis

This paper presented an approach to building background model for moving object detection using unsupervised Artificial Neural Network (ANN) without any prior knowledge about foreground objects. First, using Local Binary Pattern (LBP) which is texture feature, builds a statistical Background Model using ANN, then, comparing the behavior of next incoming frame with model and decide each pixel whether is deviating from a model or not. And based on if method detects foreground objects then background model is updated to make this model adaptive. Also, spatial-temporal information has been exploited in this method to suppress sudden illumination variation and to suppress false foreground pixels. It was demonstrated and proved, by qualitative and quantitative metrics that the newly presented approach is adaptive, generic and can address all issues and challenges for background subtraction. To evaluate the performance of the presented approach this paper compared with recent approaches by using standard metrics and proved that presented method outperforms many existing recent approaches.
Kidney transplantation without interruption of warfarin

Some patients undergoing kidney transplantation (KTX) are taking warfarin. For patients at high risk for thromboembolic events, guidelines recommend bridging therapy with heparin (1); however, non-transplant data suggest that it may be safe to perform surgery without interrupting warfarin treatment based on the concept that excessive bleeding due to anticoagulation will be detectable at the time of surgery and more appropriately managed while the wound is still open compared to bleeding only becoming apparent when full dose anticoagulation is resumed (2). Additionally, bridging with heparin involves a short period of normal coagulability—maybe even hypercoagulability related to the prothrombotic state of surgery (2). There are few empiric data examining the safety of continuation of warfarin during KTX (3). Consecutive kidney-only recipients at a single center between 2011 and 2014 who received continued anticoagulation with warfarin (n = 13) were retrospectively evaluated for the primary composite end point of hematoma requiring further sur-
Metoclopramide and perphenazine in the prevention of postoperative nausea and vomiting.

SUMMARY Metoclopramide 10 mg and perphenazine 5 mg were compared in a double-blind trial on 188 women undergoing planned gynaecological laparotomies. Metoclopramide or perphenazine was given intramuscularly at the end of the operation, and the patients were observed for 6 hours in the recovery ward. The metoclopramide-treated group had significantly less nausea, retching and vomiting than the perphenazine-treated group. The difference was significant at the 0.5 per cent level when comparing the “nausea-score” of the two groups by a Wilcoxon-Mann-Whitney test, at the 2.5 per cent level when comparing the incidence of retching and vomiting in the two groups by a λ2 test. The awakening time was slightly longer in the metoclopramide-treated group than in the perphenazine-treated group. There was no significant effect on blood pressure or pulse rate in either group. A significantly lower incidence of pethidine injections was noted in the metoclopramide-treated group than in the perphenazine-treated group. This has no effect on the conclusion that metoclopramide 10 mg is more effective in preventing postoperative nausea and vomiting than perphenazine 5 mg.