Miracle-dz/UniFAR-FTUs huggingface dataset:
Infant temperament and noncompliant behavior at four years: a longitudinal study.

Noncompliant behavior in early childhood (i.e., exaggerated, but age-appropriate negativism) has been inadequately studied. This longitudinal study explores preschool temperament and maternal behavior as current correlates of negativistic behavior at age 4, and early maternal characteristics and infant temperament as etiological variables in the production of negativism. Longitudinal evidence was collected from 62 mother-child dyads, representative of all social classes. This evidence included home observations of maternal and child behavior at 4 years, a temperament questionnaire at 4 years, a questionnaire about infant temperament, and observational and interview measures at various stages from birth to 3 years, of infant behavior and maternal characteristics. The findings suggest that infant and childhood temperament (especially the degree of infant fussiness) are highly predictive of physical noncompliance, and that physical noncompliance is unrelated to maternal or demographic variables. A combination of maternal variables including warmth, closeness, and verbal directiveness, both positive and negative, as well as child variables, predict verbal noncompliance. Demographic variables, temperament, and maternal attitudes predict passive noncompliance. Noncompliance is viewed as a complex phenomenon in which constitutional and environmental variables interact.
Transfusing neonates based on platelet count vs. platelet mass: A randomized feasibility-pilot study

Abstract The objective of this study was to obtain pilot data on which to judge the feasibility and sample size needed for a future comparative-effectiveness trial of platelet transfusions in the NICU. We conducted a limited-scope pilot trial in which neonates were randomized to receive platelet transfusions based on platelet mass vs. platelet count, using preset “transfusion-trigger” values. Analysis included parental consent rate, number of platelet transfusions given, bleeding episodes recorded, and mortality rate. Statistical analysis included ANOVA and Chi-square. A convenience sample of 30 were randomized; 15 per group. No differences were found between groups in gestational age, birth weight, race, gender or clinical diagnoses. The study consent rate was 52% (30/58). No differences were found in number of platelet transfusions received, bleeding episodes, or mortality. Lack of a trend in transfusion-reduction resulted in inability to estimate the number needed in a future comparative-effectiveness trial. Using platelet mass, rather than platelet count, for a NICU platelet transfusion trigger is feasible. However, any future comparative-effectiveness trial, testing the hypothesis that a platelet mass-based trigger reduces the transfusion rate will likely require a very large sample size.
RENAL PATHOLOGY ASSOCIATED WITH LITHIUM THERAPY

Summary Renal biopsies have been examined in patients either currently (50 patients) or previously (5 patients) on maintenance lithium therapy for severe affective disorders. In patients currently taking lithium, a distinctive lesion of the distal convoluted tubules and collecting ducts was identified. This lesion consisted of vacuolation and swelling of the cytoplasm with accumulations of PAS positive material; this material was confirmed to be particulate glycogen by light and ultrastructural techniques. This ‘lithium‐associated’ lesion was not present in patients who had discontinued lithium therapy. Prospective studies showed that the accumulation of glycogen occurs in distal tubules and collecting ducts within days of commencing lithium treatment. The relationship of this distinctive lesion to the patchy focal cortical interstitial fibrosis seen in these biopsies remains to be elucidated.
Laddered questions and qualitative data research interviews.

BACKGROUND Nurse researchers frequently make use of open interviews in their studies, hoping to understand the private world of respondents, and in particular the ways in which thought and behaviour are connected to each other. Unfortunately, there is scant guidance on how to translate such goals into the specifics of interview technique, particularly the use of probing questions. The success of such interviews rests on working ethically and understanding the respondents needs during interview. AIMS This paper explains a technique designed to direct the use of probing in interviews, and argues that its selective use might provide richer data than other ad hoc approaches employed by neophyte researchers. CONCLUSION It is argued that the technique increases the awareness of the researcher to ethical concerns and enables her or him to respond more sensitively. Laddered question technique is evaluated with reference to my own research into the negotiation of student support amongst nurse distance learners.
How Does the Brain Keep Information “in Mind”?

For decades, theoreticians and experimentalists have worked under the assumption that the short-term retention of information depends on elevated activity in the neural elements that represent this information. This was reinforced by the observation of elevated activity in the prefrontal cortex (PFC) during the performance of working memory tasks. Increasingly, however, researchers are realizing that the face-value interpretation of regional patterns of elevated activity, including in the PFC, is constrained, a priori, to the principle that brain functions (like working memory) are organized in a modular manner. This is at odds with our current understanding of the brain as a highly distributed, dynamical system capable of multiplexed processing. An alternative empirical approach, the application of multivariate pattern analysis to neural data sets, has led to two important developments in our conceptualization of working memory. First, it has shown that sustained delay-period activity in the PFC (and elsewhere) often does not correspond to the active retention, per se, of information. Second, it has provided strong empirical evidence for two mechanisms that may underlie our ability to keep in mind small amounts of information with which we can guide our behavior: sensorimotor recruitment, and the temporary activation of long-term memory representations.
Measuring vocabulary by free expression and recognition tasks: Implications for assessing children, adolescents, and young adults

Vocabulary tests are commonly used for assessing verbal ability. Most vocabulary tests employ the free expressive format that taps both verbal knowledge and expressive ability. The recognition format, which requires less expressive ability, has been suggested to be more sensitive in assessing the fund of verbal knowledge. We assessed vocabulary performance of 285 normal individuals (aged 6 to 23 years) using both free expressive and recognition tasks. Results showed that participants aged 6 to 15 performed significantly better on the recognition than on the free expressive task. While the recognition task significantly correlated with the Test of Nonverbal Intelligence–Third Edition (TONI-III) IQ for individuals aged 9 and above, the free expressive task correlated with TONI-III IQ only for young adults. Shortened 18-item versions yielded high reliability and correlation with the full version and reliable association with TONI-III IQ. These results highlight the utility of recognition tasks in measuring the fund of knowledge and suggest the possibility of developing shorter vocabulary tests for more cost-effective assessment.
Tuning the threshold voltage of MoS2 field-effect transistors via surface treatment.

Controlling the threshold voltage (Vth) of a field-effect transistor is important for realizing robust logic circuits. Here, we report a facile approach to achieve bidirectional Vth tuning of molybdenum disulfide (MoS2) field-effect transistors. By increasing and decreasing the amount of sulfur vacancies in the MoS2 surface, the Vth of MoS2 transistors can be left- and right-shifted, respectively. Transistors fabricated on perfect MoS2 flakes are found to exhibit a two-fold enhancement in mobility and a very positive Vth (18.5 ± 7.5 V). More importantly, our elegant hydrogen treatment is able to tune the large Vth to a small value (∼0 V) without any performance degradation simply by reducing the atomic ratio of S : Mo slightly; in other words, it creates a certain amount of sulfur vacancies in the MoS2 surface, which generate defect states in the band gap of MoS2 that mediates conduction of a MoS2 transistor in the subthreshold regime. First-principles calculations further indicate that the defect band's edge and width can be tuned according to the vacancy density. This work not only demonstrates for the first time the ease of tuning the Vth of MoS2 transistors, but also offers a process technology solution that is critical for further development of MoS2 as a mainstream electronic material.
Vision-guided behavior acquisition of a mobile robot by multi-layered reinforcement learning

This paper proposes multi-layered reinforcement learning by which the control structure can be decomposed into smaller transportable chunks and therefore previously learned knowledge can be applied to related tasks in a newly encountered situation. The modules in the lower networks are organized as experts to move into different categories of sensor output regions and to learn, lower level behaviors using motor commands. In the meantime, the modules in the higher networks are organized as experts which learn higher level behavior using lower modules. We apply the method to a simple soccer situation in the context of RoboCup, show the experimental results, and provide a discussion.
Atheists, agnostics and Alcoholics Anonymous.

OBJECTIVE In spite of the strong emphasis in AA on spiritual beliefs and practices, findings are mixed about the importance of such beliefs in predicting AA affiliation. This study of the Project MATCH outpatient (N = 952) and aftercare (N = 774) samples tested three hypotheses about the role of client God belief and subsequent AA attendance and benefit, taking into account that some individuals may, in fact, deny the existence of a God. METHOD Longitudinal analyses were conducted (N = 1,526) investigating client God beliefs, AA attendance, patterns of AA attendance and alcohol use. Assessments were conducted at intake and in 3-month intervals using the Form 90, Religious Behaviors and Background, and the Alcoholics Anonymous Inventory. RESULTS 12-Step treatment was significantly more likely to promote pre-post shifts in client God beliefs, and atheist and agnostic clients attended AA significantly less often throughout follow-up relative to clients self-labeled as spiritual and religious. AA attendance, however, was significantly associated with increased abstinence and reductions in drinking intensity regardless of God belief. Finally, no differences in percent days abstinence and drinking intensity were found between atheist and agnostic versus spiritual and religious clients, but clients unsure about their God belief reported significantly higher drinking frequency relative to the other groups. CONCLUSIONS God belief appears to be relatively unimportant in deriving AA-related benefit, but atheist and agnostic clients are less likely to initiate and sustain AA attendance relative to spiritual and religious clients. This apparent reticence to affiliate with AA ought to be clinically recognized when encouraging AA participation.
Connexin-43 Hemichannels Opened by Metabolic Inhibition*

The cause of altered ionic homeostasis leading to cell death during ischemia and metabolic inhibition is unclear. Hemichannels, which are precursors to gap junctions, are nonselective ion channels that are permeable to molecules of less thanM r 1000. We show that hemichannels open upon exposure to calcium-free solutions when they are either heterologously overexpressed in HEK293 cells or endogenously expressed in cardiac ventricular myocytes. In the presence of normal extracellular calcium, hemichannels open during metabolic inhibition. During ischemia and other forms of metabolic inhibition, activation of relatively few hemichannels will seriously compromise the cell’s ability to maintain ionic homeostasis, which is an essential step promoting cell death.
Rabies in the dog

The presenting signs are described of 19 dogs that were observed from the time of presentation until death. Rabies was confirmed by laboratory tests in each case. Vicious behaviour was seen in only six dogs. Paralytic signs and/or abnormal behaviour--the so-called "dumb" rabies--were more frequent. Six of the dogs had received Flury strain LEP vaccination. Intense conjunctival congestion was an important diagnostic feature.
Physical and chemical signatures of a developing anticyclonic eddy in the Leeuwin Current, eastern Indian Ocean

A multidisciplinary cruise aboard the R/V Southern Surveyor was conducted in May 2006 to sample a developing anticyclonic eddy of the Leeuwin Current off Western Australia. The eddy formed from a meander of the Leeuwin Current in mid-April 2006 and remained attached to the current until mid-August. In this study, a combination of satellite data (altimeter, sea surface temperature, and chlorophyll a) and shipboard measurements (acoustic Doppler current profiler and conductivity-temperature-depth) were used to characterize the physical and chemical signatures of the eddy. The temperature-salinity properties of the mixed layer waters within the anticyclonic eddy and on the shelf were both connected to that of the Leeuwin Current, indicating the water mass in the eddy is mainly derived from the Leeuwin Current and the modified Leeuwin Current water on the shelf. Above the salinity maximum near the eddy center, there was a regionally significant concentration of nitrate (>0.9 μmol L-1), and the maximum (2 μmol L-1) was at 150 in depth, below the photic zone. Nitrification within the eddy and/or local upwelling due to the forming eddy could be responsible for this high concentration of nitrate near the eddy center which potentially makes the eddy a relatively productive feature in the Leeuwin Current.
Oral care in the adult intensive care unit.

BACKGROUND Nurses have not been formally trained in assessing the oral status of patients in intensive care units, and no oral care protocols for these patients are available. OBJECTIVES To assess the oral status of patients in an intensive care unit, evaluate the effects of a defined oral care protocol on the oral health status of patients in an intensive care unit, and compare oral assessments of a dental hygienist with those of intensive care nurses. METHODS A nonequivalent comparison group, longitudinal design with repeated measures was used. In phase 1, oral assessment data on the comparison group were collected by a dental hygienist. In phase 2, nurses were instructed in oral assessment and an oral care protocol. In phase 3, the oral care protocol was implemented in the treatment group, and oral assessment data were collected separately by the dental hygienist and by nurses. RESULTS The mean inflammation score was significantly lower (t test P = .03) in the treatment group (mean, 3.9; SEM, 3.0) than in the comparison group (mean, 12.4; SEM, 2.2). Although not significant, the mean scores of the treatment group were also lower than those of the comparison group on scales of candidiasis, purulence, bleeding, and plaque. Correlations between scores for individual items on the oral assessment tool obtained by the dental hygienist and those obtained by nurses were all greater than 0.6386. CONCLUSION Implementation of a well-developed oral care protocol by bedside nurses can improve oral health of patients in the intensive care unit.
Understanding and addressing socio-cultural barriers to medical male circumcision in traditionally non-circumcising rural communities in sub-Saharan Africa

Given recent clinical trials establishing the safety and efficacy of adult medical male circumcision (MMC) in Africa, attention has now shifted to barriers and facilitators to programmatic implementation in traditionally non-circumcising communities. In this study, we attempted to develop a fuller understanding of the role of cultural issues in the acceptance of adult circumcision. We conducted four focus-group discussions with 28 participants in Mutoko, Zimbabwe, and 33 participants in Vulindlela, KwaZulu-Natal, South Africa, as well as 19 key informant interviews in both settings. We found the concept of male circumcision to be an alien practice, particularly as expressed in the context of local languages. Cultural barriers included local concepts of ethnicity, social groups, masculinity and sexuality. On the other hand, we found that concerns about the impact of HIV on communities resulted in willingness to consider adult male circumcision as an option if it would result in lowering the local burden of the epidemic. Adult MMC-promotional messages that create a synergy between understandings of both traditional and medical circumcision will be more successful in these communities.
An ultrastructural study of smooth muscle‐like cells in the theca externa of ovarian follicles in the rat

The cells of the theca externa of large, antral ovarian follicles in the rat were studied by electron microscopy. Many resembled fibroblasts, while others possessed cytoplasmic filaments and dense bodies characteristic of smooth muscle cells. Filament‐containing cells of intermediate structure appeared to represent transitional forms between the two previous types.
Plasma Pentraxin 3, but not high-sensitivity C-reactive protein, is a useful inflammatory biomarker for predicting cognitive impairment in elderly hypertensive patients.

BACKGROUND Due to the increasing longevity of human populations worldwide, there is need of a useful biomarker for the early detection of cognitive impairment in elderly persons. Both high blood pressure (BP) and inflammatory processes have been reported to be involved in cognitive impairment via cerebrovascular atherosclerosis or neuronal cell damage. METHODS In this cross-sectional study of 210 ambulatory elderly hypertensive patients without clinically evident dementia (mean age: 74 years; 44% men), we measured 24-hour BP, circulatory pentraxin 3 (PTX3) and high-sensitivity C-reactive protein (hs-CRP) levels, and cognitive function (Mini-Mental State Examination [MMSE]). RESULTS A high plasma PTX3 level was observed in lean subjects, especially in those whose current body weight was lower than that measured 5 years earlier, whereas a high hs-CRP level was associated with obesity (all p < .05). Both PTX3 and hs-CRP levels were significantly associated with the MMSE score (r = -.248, p<0.001 and r = -.153, p<0.05, respectively); however, in multiple regression analysis, the PTX3 level, but not the hs-CRP level, was inversely associated with the MMSE score independently of patient demographics, glucose and lipid metabolic parameters, 24-hour systolic BP (SBP) level, and the atherosclerotic burden (all p < .05). Moreover, there was a significant interaction between the PTX3 and 24-hour SBP levels in the determinants of MMSE score (p < .05). CONCLUSIONS A high plasma PTX3 level in elderly hypertensive patients, particularly in those with a high 24-hour BP level, could be a significant predictor of cognitive impairment. A high PTX3 level may be a marker of frailty in elderly hypertensive patients.
Wells'syndrome: is there collagen damage in the flame figures?

Flame figures are a characteristic histologic feature of Wells'syndrome (eosinophilic cellulitis). In this light and electron microscopic study, the ultrastructure of flame figures is described. Collagen fibers were encrusted with free eosinophil granules. No collagen damage was found. Flame figures most probably represent a transient result of unusual eosinophil activity.
Semi-supervised deep kernel learning

Deep learning techniques have led to massive improvements in recent years, but large amounts of labeled data are typically required to learn these complex models. We present a semi-supervised approach for training deep models that combines the feature learning capabilities of neural networks with the probabilistic modeling of Gaussian processes and demonstrate that unlabeled data can significantly improve performance on real-world datasets.
Subclinical and Clinical Eating Disorders in IDDM Negatively Affect Metabolic Control

OBJECTIVE To characterize the relationship of subclinical and clinical eating disorders to HbA1c values in women with IDDM. RESEARCH DESIGN AND METHODS Ninety women with IDDM (18–46 years of age) were recruited from diabetes clinics throughout Connecticut and Massachusetts. Subjects were categorized into one of three groups according to the Diagnostic Statistical Manual of Mental Disorders (DSM-III-R) criteria for eating disorders as follows: the clinical group (n = 14), the subclinical group (partially fulfilling the diagnostic criteria; n = 13), and the control group (n = 63). Group differences in the degree of dietary restraint, binge eating, and bulimic behaviors and weight, shape, and eating concerns were assessed with the Eating Disorder Examination (EDE) and the Bulimia Test Revised (BULIT-R). RESULTS Women with subclinical and clinical eating disorders had clinically elevated HbA1c results and more diabetes-related complications, compared with the control subjects. The severity of bulimic behaviors, weight concerns, reduced BMI, and decreased frequency of blood glucose monitoring were associated with elevated HbA1c. CONCLUSIONS HbA1c may have clinical utility in the identification of eating disorder behavior in females with IDDM. Health care professionals should be aware of the potent effect of subclinical and clinical eating behaviors including insulin misuse in weight-conscious women with IDDM who have poor glycemic control.
Uncovering the affective core of conscientiousness: the role of self-conscious emotions.

We conducted 3 studies to test the idea that guilt is a key affective component of Conscientiousness and that it can account for the relation between Conscientiousness and negative affect. Study 1 used meta-analysis to show that Conscientiousness was associated with specific emotions and overall negative affect but was most strongly associated with guilt. Conscientiousness was negatively related to guilt experience but positively related to guilt proneness. Also, guilt experience mediated the relation between Conscientiousness and negative affect. Study 2 (N = 142) examined the relation between facets of Conscientiousness and guilt. We replicated results from Study 1 and showed that the relation between Conscientiousness and guilt was not due to overlap with Extraversion and Neuroticism. Study 3 (n = 176) examined the interplay between Conscientiousness and guilt on grades in a short-term longitudinal study. These studies showed that Conscientiousness is primarily related to guilt and highlighted the importance of examining the emotional substrate of Conscientiousness.
Urinary tract infection caused by Enterobacter taylorae

We present a case of urinary tract infection caused by Enterobacter taylorae in a 70-year-old male with renal lithiasis. The microorganism was isolated in significant numbers from a urine culture. The disappearance of clinical symptoms after antibiotic treatment points to the participation of this microorganism as the etiological agent in the infection.