Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of root length following treatment with clear aligners and two different fixed orthodontic appliances. A pilot study

OBJECTIVES: The purpose of this pilot study was to evaluate the root lengths of upper incisors as an indication of the degree of orthodontically-induced apical root resorption following treatment with Smart Track® aligners and compare it with two different fixed orthodontic appliances – regular and Damon brackets – using cone-beam computerized tomography (CBCT). MATERIALS AND METHODS: The sample comprised 33 patients with class I malocclusion and 4–6 mm crowding divided in 3 groups; Group I: 11 patients treated with Smart Track® aligners, group II: 11 patients treated with Damon brackets, and group III: 11 patients with regular brackets. Maxillary incisors teeth lengths were assessed using Dolphin imaging software before and after treatment. All data were analyzed using analysis of variance and t-test. RESULTS: All groups showed statistically significant root resorption, 0–1.4 mm for clear aligners, 0.1–2.3 mm for Damon, and 0–2.5 mm for regular brackets group. However, cases treated with fixed appliance in general showed significantly higher resorption than those treated with Smart Track® aligners (P < 0.05). CONCLUSION: Orthodontically-induced root resorption, as evaluated by root length, is an inevitable drawback with different orthodontic techniques. However, the use of Smart Track® aligners showed less root resorption relative to regular fixed appliances.
A Crater-Exposed Bedrock Database for Mars with Applications for Determining the Composition and Structure of the Upper Crust

COMPOSITION AND STRUCTURE OF THE UPPER CRUST. L. L. Tornabene, A. S. McEwen, C. Caudill, G. R. Osinski, J. J. Wray, G. A. Marzo, J. F. Mustard, J. R. Skok, J. A. Grant, and S. Mattson, LPL (University of Arizona, Tucson, AZ; livio@pirl.lpl.arizona.edu), Dept. of Earth Sciences (University of Western Ontario, London, ON), Dept. of Astronomy (Cornell University, Ithaca, NY), Bay Area Environmental Research Institute (Sonoma, CA), NASA Ames (Moffett Field, CA), Dept. of(Brown University, Providence, RI), CEPS, (Smithsonian Institute, Washington DC).
Secure sharing of mobile personal healthcare records using certificateless proxy re‐encryption in cloud

The ubiquitous and timely access to personal health records help physicians to take critical decisions and save lives. Cloud computing has a potential to provide ubiquitous and on‐demand instant access to common pool of shared resources and services to various stakeholders involved in electronic healthcare industry such as patients, healthcare professionals, insurance companies, etc. The speedy evolution and adoption of cloud computing in electronic healthcare systems have inevitably raised concerns enveloping outsourced data in a myriad of safety issues. In this paper, cryptanalysis of Qin's scheme is performed breaching confidentiality of their scheme. We further proposed a lightweight and pairing free single‐hop unidirectional certificateless proxy re‐encryption scheme based on elliptic curves for secure sharing of mobile personal health records with public cloud competent for low‐power mobile devices. In certificateless proxy re‐encryption, patients encrypt the data with their public keys before outsourcing to the cloud and cloud resident semitrusted proxy further re‐encrypts into ciphertext under intended recipient's public key without learning anything about encrypted message. We prove its security through formal analysis against chosen ciphertext attack in the random oracle model. Our proposed scheme is more efficient and suitable for low‐power mobile devices in comparison with existing schemes.
Obesity and its Effects on Health in Middle-Aged Women from Slums of Pune

Aim: The study aims to find out the prevalence of obesity and its consequences on the health of middle-aged (45–59 years) women in slum areas. Methodology: The present study includes 559 women between 45 and 59 years of age from slums of Pune city, Maharashtra. Data were collected using a structured questionnaire, anthropometric measurements, physical activity using International Physical Activity Questionnaire long version, information on dietary habits, chronic illnesses, etc., Univariate analysis and further multiple logistic regressions were used to determine associations and risk estimates using Statistical Package for the Social Science version 16. Results: About 60% had body mass index (BMI) above normal, 39% were overweight, and 21.3% obese. The percentage of obesity increased with increasing age. Obesity was significantly associated with working status (P = 0.042), hypertension (P = 0.013), knee pain (P = 0.029), squatting (P = 0.001), walking (P = 0.001), climbing stairs (P = 0.004), and rising from chair (P = 0.040). Functional decline was reported by 62.8% women. Odds of having high blood pressure 1.8 (95% confidence interval [CI]: 1.1–3.0), difficulty in squatting, walking was 1.5 (95% CI: 1.0–2.4) and 1.9 (95% CI: 1.0–3.6) respectively more in overweight. Higher odds of having blood pressure 1.8 (95% CI: 1.0–3.3) and difficulty in walking 2.4 (95% CI: 1.2–4.6) was observed in obese women as compared to women in normal BMI category. Conclusion: The study shows that the prevalence of obesity is higher among women even in the low-income areas. This indicates a need for specific interventions targeted to women in urban slum. The inclusion of multicomponent intervention will prove to be beneficial at the community level.
Dietary Supplement and Complementary and Alternative Medicine Use Are Highly Prevalent in Patients with Gastrointestinal Disorders: Results from an Online Survey

ABSTRACT The use of complementary and alternative medicine (CAM) is widespread among adults in the United States to self-treat a range of disorders, including gastrointestinal (GI) disorders. This study determined the self-reported use of CAM, including dietary supplements, in managing GI symptoms among Internet users and investigated perceived effects of supplement use on GI symptoms. We used a cross-sectional, descriptive, correlational design. A Qualtrics online survey was utilized to collect data through various websites. Focused areas include demographics, health evaluation, health issue(s), supplement and CAM use, and GI symptoms. Of the participants included in the study, a majority (88%) were women and half (50.1%) were between the ages of 26 and 45. Most participants (84.5%) reported use of herbal supplements, and 84.8% of the participants used herbal supplements for a specific health problem. The most common reported health condition was gastroesophageal reflux (44.4%). The attrition rate was low at 22%. The novelty of using an anonymous online survey to collect data on supplement use in GI disorders indicated a high prevalence of dietary and herbal supplement use among persons with GI disorders comparable to previous reports. Health-care providers should ask patients about supplement use in addition to prescribed medications and communicate effectively if conventional pharmacotherapy is not sufficient to manage symptoms or patients are inclined to use supplements.
ESGO Survey on Current Practice in the Management of Cervical Cancer

Objective The aim of this survey was to acquire an overview of the current management of cervical cancer with an emphasis on the early disease stages. Materials and Methods A hyperlink to the survey was sent to the European Society of Gynaecological Oncology Office database. The survey contained 6 groups of questions regarding the characteristics of respondents, pretreatment workup, management of the early stages of cervical cancer, adjuvant treatment, fertility-sparing treatment, and surveillance. Results In total, 566 responses were collected. The most frequent imaging method used in the workup was magnetic resonance imaging (74%), followed by computed tomography (54%) and positron emission tomography/computed tomography (25%). Conization or simple hysterectomy was a preferred procedure in stage T1a1 lymphovascular space invasion (LVSI)–positive for 79% of respondents, in stage T1a2 LVSI-negative for 58%, and in stage T1a2 LVSI-positive for 28%. Sentinel lymph node biopsy alone was reported in stage T1a1 by 17% and in stage T1b1 less than 2 cm by 9%, whereas systematic lymphadenectomy by 29% and 90% of respondents. Macrometastases, micrometastases, and isolated tumor cells in lymph nodes were considered indications for adjuvant treatment by 96%, 93%, and 68% of respondents, respectively. Neoadjuvant chemotherapy was reported by 28% and 19% of respondents in fertility-sparing and nonsparing management in stage T1b1. Over 60% of respondents recommend primary surgery for their patients with T1b2 N0 disease and 81% of them use a combination of adverse prognostic factors as indication for adjuvant radiotherapy in pN0 disease. Conclusions The results of this survey indicate considerable differences in the workup and treatment of cervical cancer in current clinical practice.
Neural Processing of Acoustic and Electric Interaural Time Differences in Normal-Hearing Gerbils

Bilateral cochlear implants (CIs) provide benefits for speech perception in noise and directional hearing, but users typically show poor sensitivity to interaural time differences (ITDs). Possible explanations for this deficit are deafness-induced degradations in neural ITD sensitivity, between-ear mismatches in electrode positions or activation sites, or differences in binaural brain circuits activated by electric versus acoustic stimulation. To identify potential limitations of electric ITD coding in the normal-hearing system, responses of single neurons in the dorsal nucleus of the lateral lemniscus and in the inferior colliculus to ITDs of electric (biphasic pulses) and acoustic (noise, clicks, chirps, and tones) stimuli were recorded in normal-hearing gerbils of either sex. To maintain acoustic sensitivity, electric stimuli were delivered to the round window. ITD tuning metrics (e.g., best ITD) and ITD discrimination thresholds for electric versus transient acoustic stimuli (clicks, chirps) obtained from the same neurons were not significantly correlated. Across populations of neurons with similar characteristic frequencies, however, ITD tuning metrics and ITD discrimination thresholds were similar for electric and acoustic stimuli and largely independent of the spectrotemporal properties of the acoustic stimuli when measured in the central range of ITDs. The similarity of acoustic and electric ITD coding on the population level in animals with normal hearing experience suggests that poorer ITD sensitivity in bilateral CI users compared with normal-hearing listeners is likely due to deprivation-induced changes in neural ITD coding rather than to differences in the binaural brain circuits involved in the processing of electric and acoustic ITDs. SIGNIFICANCE STATEMENT Small differences in the arrival time of sound at the two ears (interaural time differences, ITDs) provide important cues for speech understanding in noise and directional hearing. Deaf subjects with bilateral cochlear implants obtain only little benefit from ITDs. It is unclear whether these limitations are due to between-ear mismatches in activation sites, differences in binaural brain circuits activated by electric versus acoustic stimulation, or deafness-induced degradations in neural ITD processing. This study is the first to directly compare electric and acoustic ITD coding in neurons of known characteristic frequencies. In animals with normal hearing, populations of auditory brainstem and midbrain neurons demonstrate general similarities in electric and acoustic ITD coding, suggesting similar underlying central auditory processing mechanisms.
Mucormycosis of the Thyroid Gland: A Cataclysmic Event in Renal Allograft Recipient

Invasive fungal infection is a complication seen in immunocompromised patients. A disseminated fungal infection has a high rate of mortality. Although disseminated infection is known to be seen in most organs, thyroid involvement is rarely reported. Hence, we report a fatal case of thyroid mucormycosis which resulted into laryngeal nerve paralysis and death of a renal allograft recipient.
Suppression of Th1-Mediated Keratoconjunctivitis Sicca by Lifitegrast.

PURPOSE Increased interferon gamma (IFN-γ) expression in dry eye causes ocular surface epithelial disease termed keratoconjunctivitis sicca (KCS). The purpose of this study was to investigated the effects of the LFA-1 antagonist, lifitegrast, in a mouse desiccating stress (DS) dry eye model that develops KCS similar to Sjögren syndrome. METHODS Mice were treated with vehicle or lifitegrast twice daily for 5 days and expression of Th1 family genes (IFN-γ, CXCL9, and CXCL11) was evaluated by real-time polymerase chain reaction. Cornea barrier function was assessed by Oregon Green dextran staining and goblet cell number and area were measured. RESULTS Compared to the vehicle-treated group, the lifitegrast-treated group had significantly lower expression of Th1 family genes, less corneal barrier disruption, and greater conjunctival goblet cell density/area. CONCLUSIONS These findings indicate that lifitegrast inhibits DS-induced IFN-γ expression and KCS. This suggests that ICAM-LFA-1 signaling is involved with generation of Th1 inflammation in KCS.
The impact of automation on the safety of drug dispensing in nursing homes.

OBJECTIVE To compare the frequency and seriousness of notified dispensing errors in nursing homes when medication is dispensed manually versus automatically using a specifically selected automatic dispensing system. METHOD A pre-post retrospective observational study in 7 nursing homes. We compare voluntarily notified dispensing errors in a manually dispensed weekly system on the one hand (year 2013), with an Automated Tablet Dispensing and Packaging System Xana4001U2 Tosho® for oral solid drugs used in combination with a manual system for other drug forms (year 2015), on the other. We analyze patient function, cognition and pharmacological data in two time periods. RESULTS Residents' mean age (83.9 vs 83.6 years; p > 0.05) and physical functioning (Barthel index 41.8 vs 44.2; p > 0.05) were similar, but not cognitive functioning (MMSE 20.3 vs 21.7; p < 0.0,5). During the year previous to the automated dispensing, 408 errors were detected with the manual system, whereas only 36 were detected in the following yearwith the automated system. This represents a reduction of 91% in dispensing errors. 43 errors reached the patient during the manually dispensing year, versus 6 during the automated year. And 5 errors versus 1 required monitoring. CONCLUSIONS The introduction of an automatic tablet dispensing and packaging system has shown to be an important improvement in safety in the dispensing and administration of solid drugs in nursing homes. The voluntary notification of errors has permitted the comparison of safety during two time periods with different dispensing systems.
Satisfaction level among patients visiting a rural dental institution toward rendered dental treatment in Haryana, North India

BACKGROUND: To provide quality care to the patient's perspective and patient satisfaction are two major multidimensional concepts. In India, patient satisfaction with dental services has received only minor attention as the importance of the teeth is always neglected. OBJECTIVE: To assess the satisfaction level among patients toward dental treatment rendered at an academic institution. MATERIALS AND METHODS: A cross-sectional study was conducted among 474 voluntary camp patients visiting Department of Public Health Dentistry, Swami Devi Dyal Hospital and Dental College, Barwala, using a 14-item closed ended questionnaire which included demographic details, attitude, and practices of the participants and their satisfaction level to the treatment rendered to them was graded as highly satisfied, satisfied, and not satisfied. The data were analyzed using SPSS version 18 which covered both descriptive and inferential statistics. RESULTS: Curative and preventive treatment was mostly required in younger age groups whereas extraction and prosthetic rehabilitation were found to be present in older age groups. Lack of education and awareness was the most common reason behind not seeking treatment. Majority of the participants were satisfied with the treatment rendered and were found to be statistically significant with visiting and referrals (P < 0.01). CONCLUSION: Imparting proper and appropriate information regarding the dental treatment will definitely change the attitude of the patients, thus help in raising the satisfaction levels.
Information triangulation: A complex and agentic everyday information practice

In contemporary urban settings, information seekers may face challenges assessing and making use of the large quantity of information to which they have access. Such challenges may be particularly acute when laypeople are considering specialized or technical information pertaining to topics over which knowledge is contested. Within a constructivist grounded theory study of the health information practices of 39 young parents in urban Canada, a complex practice of information triangulation was observed. Triangulation comprised an iterative process of seeking, assessment, and sense‐making, and typically resulted in a decision or action. This paper examines the emergent concept of information triangulation in everyday life, using data from the young parent study. Triangulation processes in this study could be classified as one of four types, and functioned as an exercise of agency in the face of structures of expertise and exclusion. Although triangulation has long been described and discussed as a practice among scientific researchers wishing to validate and enrich their data, it has rarely been identified as an everyday practice in information behavior research. Future investigations should consider the use of information triangulation for other types of information, including by other populations and in other areas of contested knowledge.
Dynamic changes of CB 1 receptor expression in hippocampi of epileptic mice and humans

Zsófia Maglóczky1, Kinga Tóth1, Rita Karlócai1, Sára Nagy1, Loránd Erőss2, Sándor Czirják2, János Vajda2, György Rásonyi2, Anna Kelemen2, Vera Juhos3, Péter Halász4, Ken Mackie5, and Tamás F. Freund1 1 Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary 2 National Institute of Neurosurgery, Budapest, Hungary 3 Szent István Hospital, Department of Neurology, Budapest, Hungary 4 Pázmány Péter Catholic University, Dept. of Information Technology, Budapest, Hungary 5 The Gill Center and Department of Physiological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA
“Candidatus Nitrosotenuis aquarius,” an Ammonia-Oxidizing Archaeon from a Freshwater Aquarium Biofilter

Nitrification is a critical process for preventing ammonia toxicity in engineered biofilter environments. This work describes the cultivation and complete genome sequence of a novel AOA representative enriched from a freshwater aquarium biofilter. In addition, despite the common belief in the aquarium industry that AOB mediate ammonia oxidation, the present study suggests an in situ role for “Ca. Nitrosotenuis aquarius”-like AOA in freshwater aquarium biofilters. ABSTRACT Ammonia is a metabolic waste product excreted by aquatic organisms that causes toxicity when it accumulates. Aquaria and aquaculture systems therefore use biological filters that promote the growth of nitrifiers to convert ammonia to nitrate. Ammonia-oxidizing bacteria (AOB) have been isolated from aquarium biofilters and are available as commercial supplements, but recent evidence suggests that ammonia-oxidizing archaea (AOA) are abundant in aquarium biofilters. In this study, we report the cultivation and closed genome sequence of the novel AOA representative “Candidatus Nitrosotenuis aquarius,” which was enriched from a freshwater aquarium biofilter. “Ca. Nitrosotenuis aquarius” oxidizes ammonia stoichiometrically to nitrite with a concomitant increase in thaumarchaeotal cells and a generation time of 34.9 h. “Ca. Nitrosotenuis aquarius” has an optimal growth temperature of 33°C, tolerates up to 3 mM NH4Cl, and grows optimally at 0.05% salinity. Transmission electron microscopy revealed that “Ca. Nitrosotenuis aquarius” cells are rod shaped, with a diameter of ∼0.4 μm and length ranging from 0.6 to 3.6 μm. In addition, these cells possess surface layers (S-layers) and multiple proteinaceous appendages. Phylogenetically, “Ca. Nitrosotenuis aquarius” belongs to the group I.1a Thaumarchaeota, clustering with environmental sequences from freshwater aquarium biofilters, aquaculture systems, and wastewater treatment plants. The complete 1.70-Mbp genome contains genes involved in ammonia oxidation, bicarbonate assimilation, flagellum synthesis, chemotaxis, S-layer production, defense, and protein glycosylation. Incubations with differential inhibitors indicate that “Ca. Nitrosotenuis aquarius”-like AOA contribute to ammonia oxidation within the aquarium biofilter from which it originated. IMPORTANCE Nitrification is a critical process for preventing ammonia toxicity in engineered biofilter environments. This work describes the cultivation and complete genome sequence of a novel AOA representative enriched from a freshwater aquarium biofilter. In addition, despite the common belief in the aquarium industry that AOB mediate ammonia oxidation, the present study suggests an in situ role for “Ca. Nitrosotenuis aquarius”-like AOA in freshwater aquarium biofilters.
Clicking Health Risk Messages on Social Media: Moderated Mediation Paths Through Perceived Threat, Perceived Efficacy, and Fear Arousal

ABSTRACT This study drew on appraisal theory to examine how fear appeal messages and individual coping styles combined to drive users’ intention to click (ITC) health risk messages on social media. A 2 × 2 × 2 mixed-design experiment was conducted, with threat and efficacy as between subject factors and message as the within subject factor. The results suggested that: (1) threat and efficacy message influenced ITC via the mediating effect of perceived threat, and perceived efficacy; (2) fear arousal was positively related to intention to click; (3) blunting style used by the participant suppressed fear arousal’s ability to mobilize ITC; and (4) monitoring style had a positive main effect on ITC. Theoretical and practical implications are discussed.