Miracle-dz/UniFAR-FTUs huggingface dataset:
Treatment of Keloid Scars by Botulinum Toxin

Keloid scars are behind an invalidating aesthetic and functional problem for patients as well as pain, and the treatments currently used do not result in total, consistent resolution of this problem. Botulinum toxin type A (BoNT-A) through its antiinflammatory and antalgic action and its effect on muscular fibres, has an action on these pathological scars. We first treated retro-auricular post otoplasty keloid scarring by injecting type A Botulinum toxin in a 14-year old patient resistant to corticosteroid injections. Both ears were affected. This first patient was injected for 3 years, every 3 months. The treatment on the left ear was only BoNT-A, and on the right was BoNT-A and surgical reduction. After the very encouraging result of this case, we injected 16 other patients. Two were lost to follow-up. For the others, the results on pain and aesthetic appearance are good to very good. Of course, further randomisedcontrolled studies are required to confirm the present results so that the treatment can become more widespread.
Coconut fat and serum lipoproteins: effects of partial replacement with unsaturated fats

The aim of the present study was to examine the effect of reducing saturated fat in the diet, or partly replacing it with unsaturated fat, on the serum lipoprotein profile of human subjects. The study had two intervention periods, 8 weeks (phase 1) and 52 weeks (phase 2). In phase 1, total fat was reduced from 31 to 25 % energy (polyunsaturated fatty acids (PUFA):saturated fatty acids (SFA) ratio increased from 0.2 to 0.4) by reducing the quantity of coconut fat (CF) in the diet from 17.8 to 9.3 % energy intake. In phase 2, subjects were randomised to groups A and B. In group A total fat was reduced from 25 to 20 % energy (PUFA:SFA ratio increased from 0.4 to 0.7) by reducing the quantity of CF in the diet from 9.3 to 4.7 % total energy intake. In group B, the saturated fat content in the diet was similar to group A. In addition a test fat (a mixture of soyabean oil and sesame oil, PUFA:monosaturated fatty acids ratio 2) contributed 3.3 % total energy intake and total fat contributed 24 % energy intake (PUFA:SFA ratio increased from 0.7 to 1.1). At the end of phase 1, there was a 7.7 % reduction in cholesterol (95 % CI -3.6, -12.2) and 10.8 % reduction in LDL (95 % CI -4.9, -16.5) and no significant change in HDL and triacylglycerol. At the end of phase 2, the reduction in cholesterol in both groups was only about 4 % (95 % CI -12, 3.2) partly due the concomitant rise in HDL. The reduction in LDL at 52 weeks was significantly higher in group B (group A mean reduction 11 %, 95 % CI -20.1, -2.0 and group B mean reduction 16.2 % 95 % CI -23.5, -8.9). In phase 2, triacylglycerol levels showed a mean reduction of 6.5 % in group 2A and a mean increase of 8.2 % in group 2B. The reduction of saturated fat in the diet is associated with a lipoprotein profile that would be expected to reduce cardiovascular risk. The reduction of dietary saturated fat with partial replacement of unsaturated fat brings about changes in total cholesterol, HDL- and LDL-cholesterol that are associated with a lower cardiovascular risk.
The impact of acute reduction of continuous-flow left ventricular assist device support on cardiac and exercise performance

Background The use of the HeartMate II continuous-flow left ventricular assist device (LVAD) improves survival, quality of life and functional capacity of patients with advanced heart failure. However, no study so far has shown the benefits of these devices for cardiac function during peak exercise. Objective To assess cardiac and exercise performance in patients implanted with the HeartMate II LVAD under two settings: (i) optimal device support and (ii) reduced device support. Methods Twelve patients implanted with a HeartMate II LVAD performed a graded cardiopulmonary exercise test with respiratory gas exchange and non-invasive (rebreathing) haemodynamic measurements. After a 4 h resting period, patients performed an additional cardiopulmonary exercise test with reduced LVAD support (pump speed was reduced from optimal 9000–9600 to 6000 revs/min). Results In response to reduced HeartMate II LVAD support, resting cardiac power output and cardiac output decreased by 21% and 13%, respectively. Also at reduced device support, peak exercise cardiac power output was 39% lower (1.40±0.50 vs 2.31±0.58 W; p<0.05), peak cardiac output 30% lower (8.6±2.5 vs 12.2±2.1 l/min; p<0.05) and mean blood pressure 13% lower (74.3±14.9 vs 85.4±15.4 vs mm Hg; p<0.05). Exercise capacity was also diminished with 23% lower peak oxygen consumption (14.1±5.3 vs 18.2±4.5 ml/kg/min; p<0.05) and an 18% shorter exercise duration (516±119 vs 628±192 s; p<0.05). Conclusion It has been shown for the first time that the HeartMate II LVAD can confer both resting and peak cardiac functional benefits to patients with end-stage heart failure, thus improving exercise capacity.
Cellulases and xylanase of an anaerobic rumen fungus grown on wheat straw, wheat straw holocellulose, cellulose, and xylan

The activities of cellulolytic and xylanolytic enzymes produced by an anaerobic fungus (R1) which resembled Neocallimastix sp. were investigated. Carboxymethylcellulase (CMCase), cellobiase, and filter paper (FPase) activities had pH optima of 6.0, 5.5, and 6.0, respectively. CMCase and cellobiase activities both had a temperature optimum of 50 degrees C, whereas FPase had an optimum of 45 degrees C. The pH and temperature optima for xylanase activity were pH 6.0 and 50 degrees C, respectively. Growth of the fungus on wheat straw, wheat straw holocellulose, or cellulose resulted in substantial colonization, with at least 43 to 58% losses in substrate dry matter and accumulation of comparable amounts of formate. This end product was correlated to apparent loss of substrate dry weight and could be used as an indicator of fungal growth. Milling of wheat straw did not enhance the rate or extent of substrate degradation. Growth of the R1 isolate on the above substrates or xylan also resulted in accumulation of high levels of xylanase activity and lower cellulase activities. Of the cellulases, CMCase was the most active and was associated with either low or trace amounts of cellobiase and FPase activities. During growth on xylan, reducing sugars, including arabinose and xylose, rapidly accumulated in the medium. Xylose and other reducing sugars, but not arabinose, were subsequently used for growth. Reducing sugars also accumulated, but not as rapidly, when the fungus was grown on wheat straw, wheat straw holocellulose, or cellulose. Xylanase activities detected during growth of R1 on media containing glucose, xylose, or cellobiose suggested that enzyme production was constitutive. (ABSTRACT TRUNCATED AT 250 WORDS)
A mixed-method analysis of post-trauma outcomes: Trauma severity and social support from a psychotherapeutic oerspective

While research has focused on the difficulties faced in adapting to life following the experiences of a traumatic event, limited research has examined positive legacies of incorporating a traumatic experience into life post-trauma. This study uses quantitative and qualitative data (N = 218) to examine the effect that trauma severity and social support have on post-trauma outcomes. Individual’s perceptions of their traumatic experiences and the social support they received were significant influences post-trauma. The knowledge gained has practical applications for therapy and the client/counsellor relationship in terms of counselling and facilitating personal growth after trauma.
Antifungal Activity of Ozonized Olive Oil (Oleozone)

The effect of ozonized olive oil (Oleozone) on some pathogenic fungi (Aspergillus fumigatus, Candida albicans, Epidermophyton floccosum, Microsporum canis & Trichophyton rubrum), were tested. The olive oil was ozonized at Ozomaxe, Egypt, OZO3 VTT Cairo, Egypt by an ozone generator. Minimum inhibitory concentrations (MICs) were determined by the agar dilution method. Oleozone showed antimicrobial activity against all species analysed, with an MIC ranging from 0.53 to 2.0 mg mL. Candida albicans, Microsporum canis and Trichophyton rubrum were more susceptible to oleozone than other species tested. Microsporum canis showed the minimum decrease in dry weight (0.03 g/100 mL) under oleozone effect. The inhibition effect of oleozone on nucleic acid content was correlated to the extent of fungal growth reaching the lowest value (0.02 & 0.13 mg g dry weight) in Microsporum canis for DNA and RNA, respectively. Application of oleozone leads to a significant reduction in amylase, lipase, keratinase and urease enzyme activities for all tested fungal species.
F18-FDG-PET for recurrent differentiated thyroid cancer: a systematic meta-analysis

Background Positron emission tomography (PET) with fluor-18-deoxy-glucose (FDG) is widely used for diagnosing recurrent or metastatic disease in patients with differentiated thyroid cancer (DTC). Purpose To assess the diagnostic accuracy of FDG-PET for DTC in patients after ablative therapy. Material and Methods A systematic search was conducted in Medline/PubMed, EMBASE, Cochrane Library, Web of Science, and Open Grey looking for all English-language original articles on the performance of FDG-PET in series of at least 20 patients with DTC having undergone ablative therapy including total thyroidectomy. Diagnostic performance measures were pooled using Reitsma’s bivariate model. Results Thirty-four publications between 1996 and 2014 met the inclusion criteria. Pooled sensitivity and specificity were 79.4% (95% confidence interval [CI], 73.9–84.1) and 79.4% (95% CI, 71.2–85.4), respectively, with an area under the curve of 0.858. Conclusion F18-FDG-PET is a useful method for detecting recurrent DTC in patients having undergone ablative therapy.
Atorvastatin Improves the Impaired Baroreflex Sensitivity via Anti-Oxidant Effect in the Rostral Ventrolateral Medulla of SHRSP

We have demonstrated that oxidative stress in the rostral ventrolateral medulla (RVLM), a vasomotor center in brainstem, increases sympathetic nerve activity (SNA) and that oral administration of atorvastatin inhibited SNA via anti-oxidant effect in the RVLM of stroke-prone spontaneously hypertensive rats (SHRSPs). The impairment of baroreflex sensitivity (BRS) is known as the predictive factor of mortality in the hypertension and BRS is impaired in SHRSP. The aim of the present study was to determine whether oral administration of atorvastatin improved the impaired BRS via anti-oxidant effect in the RVLM in SHRSP. Atorvastatin (20 mg/kg/day) or vehicle was orally administered for 28 days in SHRSPs. Systolic blood pressure (SBP), heart rate, and 24-h urinary norepinephrine excretion as an indicator of SNA were comparable between atorvastatin- and control-SHRSP. Thiobarbituric acid-reactive substance (TBARS) levels as a marker of oxidative stress was significantly lower in atorvastatin-SHRSP than in control-SHRSP. Baroreflex sensitivity measured by the spontaneous sequence method was significantly higher in atorvastatin-SHRSP than in control-SHRSP. These results suggest that atorvastatin improves the impaired BRS in SHRSP via its anti-oxidant effect in the RVLM of SHRSP.
Compatibilidad vegetativa de aislamientos de Fusarium sp. obtenidos de árboles de mango (Mangifera indica L.) con malformación en Michoacán

La enfermedad malformacion es uno de los factores principalesque reducen la produccion del mango en el ambito mundial.Varias especies del hongo Fusarium causan esta enfermedad.En Michoacan se ha detectado una especie nueva de Fusariumcausando la enfermedad. Aun cuando se han realizado estudiosfilogeneticos, la diversidad poblacional de este nuevo patogeno esdesconocida. La determinacion de los Grupos de CompatibilidadVegetativa (GCV) es una herramienta utilizada para estudiar lavariabilidad genetica de poblaciones de hongos mitosporicos. Paraidentificar GCVs se utilizan mutantes auxotrofos nit en pruebasde complementacion. Los mutantes nit surgen espontaneamentecuando el hongo se inocula en medio que contenga nitrato y cloratode potasio. Estos mutantes no pueden utilizar nitrato (NO3)comofuente de nitrogeno debido a una mutacion estructural del gennit1 o en los loci que codifican para un cofactor que es parte delas enzimas nitrato reductasa y purina deshidrogenasa. Los objetivosde este trabajo fueron determinar la frecuencia de generacion demutantes, caracterizarlos fenotipicamente y determinar los gruposde compatibilidad vegetativa en aislamientos de Fusarium obtenidosde mango con malformacion. La frecuencia de generacion desectores de micelio resistentes en medio minimo mas clorato al 2%entre los aislamientos fue variable, 40%-94.4%. El 65.5% del totalde todos los sectores generados produjeron mutantes nit, siendoel tipo nit1 el mas frecuente (55.5%). Los mutantes tipos nit3 yNitM se produjeron en similar proporcion. Todos los aislamientosanalizados produjeron mutantes; sin embargo, el tipo y numero demutantes vario entre los aislamientos, caracteristica que tambienha sido observada en otras especies de Fusarium. Se detectarondos grupos de compatibilidad en estos aislamientos lo cual indicauna baja diversidad genetica en las poblaciones de Fusarium sp.causantes de malformacion del mango en Michoacan.
Nutritional interventions for preventing and treating pressure ulcers.

BACKGROUND Pressure ulcers affect 10% of people in hospitals and older people are at highest risk. The correlation between nutritional intake and the development of pressure ulcers is suggested by several studies, but the results are inconsistent. OBJECTIVES To evaluate the effectiveness of enteral and parenteral nutrition on the prevention and treatment of pressure ulcers. SEARCH STRATEGY The Cochrane Wounds Group Specialised Trials Register and the Cochrane Central register of Controlled Trials were searched in September 2002. An additional search of PubMed and Cinahl and hand search of conference proceedings and journals was performed, bibliographies of relevant articles were examined and experts in the field as well as manufacturers were contacted in order to find additional literature that may be relevant. SELECTION CRITERIA Randomised controlled trials evaluating the effectiveness of enteral or parenteral nutrition on the prevention and treatment of pressure ulcers by measuring the incidence of new ulcers, ulcer healing or changes in pressure ulcer severity. There were no restrictions on patients, setting, date, publication status or language. DATA COLLECTION AND ANALYSIS Abstracts were independently inspected and full articles were obtained of potentially relevant studies. In case of disagreement advice was sought from a third person (AK). Data extraction and assessment of quality were undertaken by the three reviewers independently. MAIN RESULTS Only 8 randomised controlled trials out of 16 potentially relevant articles were included. However, most of the 8 trials included are small and of poor methodological quality. PREVENTION Four studies compared a combination of nutritional supplements, consisting of a minimum of energy and protein in different dosages, for the prevention of pressure ulcers. The largest study found that nutritional supplements reduced the number of new pressure ulcers (Bourdel-M 2000). The three smaller studies lacked power. TREATMENT Four studies evaluated the effects of nutritional supplements for the treatment of existing pressure ulcers: one trial examined mixed nutritional supplements, one trial examined zinc, another the effect of proteins, and two studies compared ascorbic acid. The trials included are heterogeneous with regard to participants, interventions and outcomes; therefore it was considered inappropriate to perform a meta-analysis. REVIEWER'S CONCLUSIONS It was not possible to draw any firm conclusions on the effect of enteral and parenteral nutrition on the prevention and treatment of pressure ulcers. Further trials of high methodological quality are necessary.
Pemphigus foliaceus: an adverse reaction to lisinopril

Lisinopril is an angiotensin converting enzyme inhibitor used in the treatment of cardiovascular disease. We report a case of pemphigus foliaceus in a 66‐year‐old male treated with lisinopril for hypertension and a previous myocardial infarction. The drug‐induced variant of pemphigus is caused by a wide variety of drugs and is most frequently associated with captopril and penicillamine. It has not previously been reported in this commonly used drug.
Use of Elderly Donors in Liver Transplantation: A Paired-match Analysis at a Single Center

Objective: To evaluate the use of elderly donors in liver transplantation (LT) and identify risk factors associated with a worse outcome. Summary Background Data: Use of livers from very old donors could expand the donor pool but is not universally implemented. Methods: This is a retrospective, single-center medical record review. From January 2001 to December 2014, 1354 LTs were performed. After exclusion of donors <18 years, ABO-incompatible LT, re-LT and UNOS 1 status patients, LT recipients were stratified into 2 groups based on donor age: 18–69 (n=692) vs. ≥70 years (n=515) then matched using a propensity score approach. Two groups were finally matched (young group = 448 cases; old group = 515 cases). Results: The median (interquartile range [IQR]) follow-up was 5.0 (2.0–8.4) years. Comparing the 2 identified groups, no differences were observed regarding early retransplants (1.8 vs. 2.9; P = 0.3), HCV-related death (7.6 vs. 8.7%; P = 0.6), vascular (5.8 vs. 5.0%; P = 0.7), and biliary complications (16.5 vs. 18.6%; P = 0.4). On multivariate analysis, independent risk factors for graft loss were: HCV-positive recipient (HR = 2.1; 95% CI = 1.6–2.7; P < 0.001), donor age (HR = 1.0; 95% CI = 1.0–1.0; P < 0.001), cold ischemia time (HR = 1.0; 95% CI = 1.0–1.0; P = 0.042), and donor history of diabetes mellitus (HR = 1.48; 95% CI = 1.03–2.13; P = 0.036). Conclusions: Use of elderly donors is not associated per se with an increased risk of vascular and biliary complications. In the presence of cold ischemia time and diabetes mellitus, appropriate donor-to-recipient matching is warranted.
Burden among Caregivers of Clients with Depression – A Scientific Study

Burden among 30 caregivers of in-patients with depression was assessed using the BASS (Burden assessment scale, Thara etal., 1995). : Data obtained was analysed using spss 16 with descriptive statistics, t test & pearsons correlation coefficient. The subjective burden levels ranged from 67-98 and Mean Burden was 84.7 ± 9.7 suggesting moderate burden perception by the caregivers. Individual domain standardized percentage scores indicated highest burden in the domain of physical & mental health (67.9), taking responsibility (67.5), patients’ behaviour (63.8), and caregivers’ routine (61.3). Indian families are very close knit and perhaps hence standardized percentage scores seemed to be comparatively less in the other domains such as support of patient (53.8), caregivers strategy (51.3), other relations (50.0), spouse related (46.3) and external support (35.8). Mean Burden level in female caregivers (17.3) was significantly (p<0.05) higher than in male caregivers (15.5). High burden levels could predispose to depression, substance abuse, anxiety, etc. in caregivers of patients with depression. This study results indicate the need for family based interventions addressing this issue.
Carcinoma of the Rectum following Ileoproctostomy and Colectomy for Ulcerative Colitis

History: 1943: Aged 14. Onset of diarrheea with blood and mucus. He was also suspected of having pulmonary tuberculosis, but this diagnosis was not sustained after investigation. 1946: Aged 16. Weight 3 st 10 lb. Ten stools a day. 25.1. 46: Ileostomy and appendicectomy. 23.8. 46: Readmitted with acute osteomyelitis of the right radius. 12.9. 46: Drainage of bone abscess. 30.11. 46: Readmitted with osteomyelitis affecting all four limbs. Treated with penicillin and immobilization in plaster. 4.3. 47: Readmitted; pyoderma of left leg. 25.3. 47: Subtotal colectomy. The rectosigmoid stump was retained. Report (Dr C E Dukes) shows typical severe chronic ulcerative colitis. No evidence of tuberculosis (Fig 1). 25.5. 49: Aged 19. Readmitted for ileoproctostomy. The rectum was discharging once a month. 3.6. 49: Establishment of mid-line ileostomy. 28.6. 49: Amputation of ileostomy and insertion of enterotome. 12.7. 49: Extraperitoneal closure of ileostomy. 5.5. 50: Bowel actions three to four times daily. Gaining weight. Very satisfied with operation, but did not keep subsequent appointments. Since last visit the patient lost no days of work through illness until current upset. His bowel action was semi-solid, usually three times a day. He ran his own business as a decorator, married and had 3 children. July 1960: Sudden onset of central abdominal pain followed by profuse watery diarrhoea. This subsided after one month of treatment from patient's practitioner. Constipation and considerable tenesmus. The diarrheea returned whenever the medicine was not taken. Acute loss of weight. 30.9. 60: Referred to hospital with a diagnosis of recurrent ulcerative colitis. A carcinoma of the rectum could be felt with the finger tip and biopsy showed a poorly differentiated adenocarcinoma. 18.10. 60: Combined abdominoperineal excision of rectum, with terminal ileostomy (Mr Ian Todd). Fig 1 1947. Colectomy Specimen. Ulcerative colitis
Once daily nebulized beclomethasone is effective in maintaining pulmonary function and improving symptoms in asthmatic children.

BACKGROUND AND AIM Compliance with long-term inhaled therapy in asthma is often poor, but it is likely to be improved with a simplified administration, once daily. The present study was designed to assess whether, in childhood asthma, a single dose of nebulized beclomethasone dipropionate once daily was as effective and safe as the same total daily dose administered twice daily. METHODS Asthmatic children, not treated with inhaled steroids for at least a month preceding the study and using short-acting bronchodilators more than once a week were enrolled in a double-blind, double dummy, randomised, multicentric study. After a two week run-in period on nebulised twice daily 400 mcg beclomethasone dipropionate, patients were randomly assigned to twelve weeks of treatment with 800 mcg nebulised beclomethasone dipropionate daily, either in single dose (o.d. group) or divided into two 400 mcg doses (b.i.d. group). RESULTS 65 children (mean age 8.6 years, mean FEV1 81% of predicted), were valuable for intention to treat. During the run-in period, a significant improvement in FEV1, FVC, morning and evening PEF values and clinical scores was observed. Children then entered the randomised trial: 32 were included in the o.d. group and 33 in the b.i. d. group. During the twelve week treatment period, the observed improvement in pulmonary function parameters was maintained in both treatment groups. Morning and evening PEF showed a progressive slight increase as well as PEF diurnal variability showed a progressive reduction in the two treatment groups during the whole study period without reaching statistical significance. Moreover, in both treatment groups a similar progressive increase in symptom free nights and days and in the percentage of children achieving total asthma symptoms control was detected. Finally, no significant changes in urinary cortisol/creatinine ratio were observed throughout the study period and between groups. CONCLUSIONS A daily dose of 800 mcg of beclomethasone, administered for twelve weeks with a nebuliser either once or twice daily provide similar efficacy in maintaining pulmonary function and symptoms of asthmatic children, with a good tolerability profile.