Miracle-dz/UniFAR-FTUs huggingface dataset:
[Affective facial behavior of borderline patients during the Adult Attachment Projective].

OBJECTIVE In this study we investigated for the first time the facial activity of patients with Borderline Personality Disorder (BPD) compared to healthy controls during the Adult Attachment Projective (AAP). The AAP is a valid interview measure for assessing adult attachment representation. The attachment system is activated by eight attachment-related pictures. The subjects are asked to tell a story about each picture. METHODS The affective facial behavior during the AAP interview in 15 female patients with BPD and 14 healthy women was coded using EMFACS. Affective facial behavior was compared between diagnostic and attachment groups (resolved versus unresolved trauma). RESULTS As expected, there was a significantly higher number of BPD patients in the category "unresolved trauma" of the AAP. The BPD patients also showed significantly more disgust during the attachment task as compared to controls. CONCLUSIONS The two main results are discussed in the context of frequent traumatic experiences such as sexual abuse and emotional neglect suffered by BPD patients through their attachment figures.
Process and Characteristics of Fully Silicided Source/Drain (FSD) Thin-Film Transistors

In this paper, high-performance fully silicided source/drain (FSD) thin-film transistors (TFTs) with FSD and ul-trashort source/drain extension (SDE) fabricated by the implant-to-silicide (ITS) technique are studied thoroughly. Using the ITS technique, not only the implantation damage but also the silicide spiking is avoided so that the thermal budget can be decreased obviously. The offstate current (Ioff) of the FSD TFTs is equal to (n-channel) or smaller than (p-channel) that of the conventional TFTs. At onstate, due to the FSD and the SDE structure, the parasitic resistance of the S/D region and the carrier-injection resistance between silicide and channel are reduced. Therefore, superior onstate/offstate current ratio can be obtained. The influences of annealing temperature and time are also examined in this paper. A 600degC/30-s rapid thermal annealing is sufficient to diffuse and activate dopants and, then, fabricate high-performance FSD TFTs. Excellent short-channel behavior of the FSD TFT is also confirmed. To conclude, the high-performance FSD TFT with low parasitic resistance fabricated by low-thermal-budget process is very promising for active-matrix liquid-crystal display, active-matrix organic light-emitting-diode display, and system-on-panel applications
Flow cytometry CD45‐negative B‐NHL: A case report of a diffuse large B‐cell lymphoma without extranodal involvement

The loss of CD45, the leukocyte‐common antigen, has been described in rare cases of large B‐cell lymphoma (LBCL) subtypes with extranodal involvement by immunohistochemical methods. Here we report a case of a patient with LBCL, with no extranodal lesions, which is CD45 negative by flow cytometry (FC) immunophenotyping.
Effect of ‘activity monitor-based’ counseling on physical activity and health-related outcomes in patients with chronic diseases: A systematic review and meta-analysis

Abstract Aim. This review evaluated the effects of activity monitor-based counseling on physical activity (PA) and generic and disease-specific health-related outcomes in adults with diabetes mellitus type II (DMII), chronic obstructive pulmonary disease (COPD), or chronic heart failure (CHF). Methods. Four electronic databases were searched for randomized controlled trials using activity monitor-based counseling versus control intervention or usual care in adults with DMII, COPD, or CHF. Pooled effect sizes were calculated using a random effects model. Results. Twenty-four articles were included: 21 DMII studies and 3 COPD studies. No CHF studies were identified. Pooled analysis showed that activity monitor-based counseling resulted in a significantly greater improvement in PA compared to control intervention or usual care in DMII. Furthermore, these interventions had a beneficial effect on hemoglobin A1c (HbA1c), systolic blood pressure, and body mass index (BMI) (P < 0.05), whereas no differences were found on diastolic blood pressure, and health-related quality of life. Meta-analysis of COPD studies was not possible due to lack of available data. Conclusion. Activity monitor-based counseling had a beneficial effect on PA, HbA1c, systolic blood pressure, and BMI in patients with DMII. Data in patients with COPD and CHF are limited or non-existing, respectively.
Control of elevator muscle activity during simulated chewing with varying food resistance in humans.

1. During chewing, a small part of the observed muscle activity is needed for the basic open-close movements of the mandible, and much additional muscle activity (AMA) is needed to overcome the resistance of the food. In chewing cycles in which a counteracting force is expected, the AMA is mainly generated by peripheral induction with a latency of approximately 23 ms. It was investigated whether an open-loop or closed-loop mechanism is involved in the control of the AMA in these cycles. 2. Subjects made rhythmic open-close movements at their natural chewing frequency controlled by a metronome. Food resistance was simulated by an external force, acting on the jaw in a downward direction during part of the closing movement. Sequences of cycles with a force were unexpectedly alternated with sequences of cycles with a different force. The force changed from 19 to 0 N and vice versa, and from 25 to 6 N and vice versa. Jaw movement and surface electromyogram of the masseter, temporalis, and suprahyoid muscles on both sides were recorded during cycles before and after the transition from one force condition to another. 3. The movement trajectory and AMA of the second and following cycles with a new force appeared to be similar. Thus adaptation to the changed circumstances occurred within two open-close cycles. 4. In the first cycle with 0 or 6 N in the 19----0 N and 25----6 N experiments respectively, a large part of the AMA had disappeared. The AMA in this cycle started to differ from the AMA in the previous cycle approximately 23 ms after the moment the force in this cycle started to differ from the previous cycle. 5. In the first cycle with 19 or 25 N in the reverse experiments, the AMA increased 120-136 ms after the moment the force in this cycle started to differ from the previous cycle. 6. During the closing phase of each open-close cycle, no muscle activity of the suprahyoid muscles was observed; thus co-contraction with the elevator muscles did not occur. 7. It was concluded that the AMA is under control of a closed-loop mechanism with a latency of approximately 23 ms. However, the reflex output has a maximum, depending on information about the food resistance gained in previous cycles. (ABSTRACT TRUNCATED AT 400 WORDS)
Weighted Elastic Net Penalized Mean-Variance Portfolio Design and Computation

It is well known that the out-of-sample performance of Markowitz's mean-variance portfolio criterion can be negatively affected by estimation errors in the mean and covariance. In this paper we address the problem by regularizing the mean-variance objective function with a weighted elastic net penalty. We show that the use of this penalty can be motivated by a robust reformulation of the mean-variance criterion that directly accounts for parameter uncertainty. With this interpretation of the weighted elastic net penalty we derive data-driven techniques for calibrating the weighting parameters based on the level of uncertainty in the parameter estimates. We test our proposed technique on U.S. stock return data, and our results show that the calibrated weighted elastic net penalized portfolio outperforms both the unpenalized portfolio and the uniformly weighted elastic net penalized portfolio. This paper also introduces a novel adaptive support split-Bregman approach which leverages the sparse nature of $\e.
Modelos alométricos para estimativa da área foliar de mangueira pelo método não destrutivo

A area foliar e uma das mais importantes medidas de avaliacao do crescimento vegetativo; sendo assim, o conhecimento sobre tal aspecto permite estimar a perda de agua por transpiracao, devido as folhas serem os principais orgaos responsaveis pelas trocas gasosas entre a planta e o ambiente, tornando-se importante o seu estudo. Dessa forma, objetivou-se com a realizacao deste trabalho testar e obter o melhor modelo matematico para estimativa da area foliar da mangueira (Mangifera indica L.) cv. Haden em funcao das suas dimensoes alometricas. Utilizou-se um pomar localizado na propriedade Sao Domingos, no municipio de Alegre, sul do Estado do Espirito Santo, onde foram coletadas 80 folhas de 20 mangueiras em outubro de 2013. As regressoes foram determinadas considerando-se a area foliar real (AFR) como variavel dependente, e o comprimento (C), a largura (L) e o produto das dimensoes lineares (C x L) de cada folha, como variaveis independentes. Com base nos resultados obtidos, concluiu-se que a equacao polinomial y= -0,0001x²+0,6934x+4,7677 foi o melhor modelo matematico para estimar a area foliar da mangueira, com R² de 0,97. Os modelos que utilizam C x L sao os mais adequados para estimar a area das folhas da mangueira, uma vez que apresentam maior correlacao.
The Effect of Metformin on the Metabolic Abnormalities Associated With Upper-Body Fat Distribution. BIGPRO Study Group

OBJECTIVE The constellation of anomalies associated with insulin resistance is a plausible additional cause of ischemic cardiovascular disease and of NIDDM. To test this hypothesis in a primary prevention trial, the effects of metformin as a potential candidate for intervention in the insulin resistance syndrome (IRS) were evaluated in 324 middle-aged subjects with upper-body obesity. RESEARCH DESIGN AND METHODS Trial patients were selected on the basis of a high waist-to-hip ratio. They were randomly allocated to receive either metformin or placebo, following a double-blind procedure. After 1 year of treatment, the main clinical and biological parameters of the IRS were assessed and their evolution compared between treatment groups. RESULTS Compared with placebo, metformin induced a significant weight loss, a better maintenance of fasting blood glucose, total and LDL cholesterol levels, and a greater decrease of fasting plasma insulin concentration. Moreover, tissue-type plasminogen activator antigen, a marker of fibrinolytic impairment, showed a significant decrease under metformin. By contrast, metformin treatment had no significant effect on blood pressure or serum triglyceride and HDL cholesterol concentrations. The main side effect of metformin was diarrhea. CONCLUSIONS The BIGuanides and Prevention of Risks in Obesity (BIGPRO1) results suggest that metformin would be a suitable candidate for long-term intervention for the prevention of diabetes but that its use in a trial of primary prevention of cardiovascular diseases requires either a reevaluation of its properties toward the most potentially atherogenic anomalies of the IRS or a better definition of the target population.
A case‐control study of diet and lung cancer in Kerala, South India

A total of 281 male lung‐cancer patients were identified from the hospital cancer registry in the Regional Cancer Centre in Trivandrum. The controls were selected from the visitors and patients' bystanders in the hospital. The recruitment of cases and controls started in 1990, and the present study used the cases registered in the first year. The questionnaire administered to cases and controls collected information on tobacco smoking and alcohol habits. Dietary data were collected using a food frequency questionnaire and were analyzed by multiple logistic regression producing odds ratio estimates of the relative risk and deviance chi‐squared tests of significance. Analysis was done on the computer package, EGRET. All models included age, education, religion and smoking to adjust for the effect of confounding. Green vegetables and bananas were found to have a protective association with lung cancer. The odds ratio associated with the highest quartile of vegetable consumption compared with the lowest was 0.32 (95% confidence interval 0.13. 0.78). Forward stepwise regression analysis indicated pumpkins and onions as the most consistently significant protective factors. Animal protein foods and dairy products were found to have a predisposing effect on lung cancer in this study. The expected influence of smoking on lung cancer (a considerable increase in risk among smokers) provided evidence of the reliability of the data. In conclusion the results from this study show that diet has a role in lung cancer aetiology, although the association is weak compared to the effects of smoking.
Use of the polymerase chain reaction for physical mapping of Escherichia coli genes

Several investigators are currently positioning published Escherichia coli DNA sequence data on the Kohara physical map (9) by computer-aided alignment of restriction patterns (13, 14, 17). To facilitate direct correlation of the E. coli K-12 physical and genetic maps, we have used a rapid method based on the amplification of specific gene products by the polymerase chain reaction (PCR). PCR products obtained from amplification of total E. coli genomic DNA were utilized as probes in hybridization experiments with a gene mapping membrane. In an alternative strategy, the primers were used directly for the PCR amplification of phage and cosmid DNAs to detect specific sequences at defined positions in ordered E. coli genomic libraries. To physically map genes of interest, we screened a mapping panel constructed from the Kohara phage collection (version 9010) that covers greater than 99% of the E. coli genome. A single filter, or gene mapping membrane, which contains a "miniset" of 476 overlapping phage clones (16), was hybridized with each specific probe. This membrane was prepared by Takara Shuzo Co., Ltd., Kyoto, Japan, and the National Institute of Genetics, Mishima, Japan, and was provided by Akihiro Noda (16). The glpK and cca coding sequences were amplified from total E. coli K-12 W3110 genomic DNA (100 ng) by PCR using the conditions de-scribed below for the phage lysates (Table 1), gel purified (6), oligolabeled (5), and hybridized to the ordered phage filter.
HPLC analysis of the antifungal agent posaconazole in patients with haematological diseases

Posaconazole is a new antifungal drug used in prophylaxis and therapy of fungal infections in patients with immunodeficiency. In the clinical development, posaconazole exhibits variable oral bioavailability. Hence drug monitoring is recommended. For this purpose, a rapid and a convenient high‐performance liquid chromatography (HPLC) method has been developed. To 200 μl serum, 50 μl internal standard (itraconazole) was added. After precipitation of the proteins with acetonitrile, the clear supernatant was evaporated in a centrifugal evaporator, and the residue was dissolved in the HPLC elution. Separation was done on a chromatography performed by injecting a 50 μl aliquot of the resuspended sample onto a Multohyp C18 BDS column (250 × 4 mm). Column temperature was maintained at 50 °C. The flow rate was 1 ml min−1. Retention time of posaconazole was about 9 min and those of itraconazole was 17 min. The limit of quantification was 50 μg l−1 and the limit of detection about 10 μg l−1. Until now the concentration of posaconazole was measured in 14 patients (64 samples). After a daily dosage of 600–800 mg posaconazole the serum concentrations varied between 100 and 3000 μg l−1 (582 ± 579 μg l−1). Oral bioavailability was especially low in patients with cytostatic therapy and/or bone marrow transplantation. Further studies are needed to establish the therapeutic range of the posaconazole concentrations.
Spatial Deep Networks for Outdoor Scene Classification

Scene classification has become an increasingly popular topic in computer vision. The techniques for scene classification can be widely used in many other aspects, such as detection, action recognition, and content-based image retrieval. Recently, the stationary property of images has been leveraged in conjunction with convolutional networks to perform classification tasks. In the existing approach, one random patch is extracted from each training image to learn filters for convolutional processes. However, feature learning only from one random patch per image is not robust because patches selected from di↵erent areas of an image may contain distinct scene objects which make the features of these patches have di↵erent descriptive power. In this dissertation, focusing on deep learning techniques, we propose a multi-scale network that utilizes multiple random patches and di↵erent patch dimensions to learn feature representations for images in order to improve the existing approach. Despite the much better performance the multi-scale network can achieve than the existing approach, lacking of local features and the spatial layout is one of the core limitations of both methods. Therefore, we propose a novel Spatial Deep Network (SDN) to further enhance the existing approach by exploiting the spatial layout of the image and constraining the random patch extraction to be performed in di↵erent areas of the image so as to e↵ectively restrict the patches to hold the necessary characteristics of di↵erent image areas. In this way, SDN yields compact but discriminative features that incorporate both global descriptors and the local spatial information for images. Experiment results show that SDN considerably exceeds the existing approach and multi-scale networks and achieves competitive performance with some widely used classification techniques on the OT dataset (developed by Oliva and Torralba). In order to evaluate the robustness of the proposed SDN, we also apply it to the content-based image retrieval on the Holidays dataset, where our features attain much better retrieval performance but have much lower feature dimensions compared to other state-of-the-art feature descriptors.
Factors affecting survival in patients with oesophageal atresia and tracheo-oesophageal fistula.

OBJECTIVE To evaluate the various factors affecting survival in babies with oesophageal atresia and tracheo-oesophageal fistula. DESIGN Descriptive study. SETTING The study was carried out at the Department of Paediatric Surgery, The Children's Hospital, Pakistan Institute of Medical Sciences (PIMS), Islamabad from March 2004 to March 2005. PATIENTS AND METHODS All neonates with oesophageal atresia (EA) and tracheo-oesophageal fistula (TEF) during the study period were included in the study. Patients having isolated EA were excluded. A total of 80 patients were included in the study. Patients were received from the emergency department, OPD and Neonatal ICU. Diagnosis was confirmed by passing a radio opaque orogastric tube. Investigations were done to look for other associations. After stabilisation, right thoracotomy was performed, fistula was ligated and divided. An attempt was made to do a primary oesophago-oesopahgostomy. Nasogastric feeding was started on 2nd post-operative day. A contrast oesophagogram was performed on the 7th postoperative day and having ruled out leak, oral feeding was started. RESULTS Out of the total, 33 (41%) survived and 47 (58%) patients died. Out of 47 deaths 20 (25%) died before surgery and 27 (34%) died after surgery. Mean follow up period was 6 months. Sixteen (20%) patients had anastomotic leak, 24 (30%) had anastomotic stricture, and 64 (80%) patients had postoperative pneumonia. CONCLUSION We conclude that proper antenatal check ups will detect the problem early, avoid home deliveries and hence improve survival. Pneumonitis and septicaemia significantly affect survival. Availability of ICU is one of the main determinants of survival. The likely cause of high mortality rate in pre-operative patients in our series is non-availability ofNICU due to limited space in our setup.
Potassium conductances underlying repolarization and after‐hyperpolarization in rat CA1 hippocampal interneurones.

1. The roles of multiple potassium conductances underlying action potential repolarization and after‐hyperpolarization (AHP) in visually identified st. oriens‐alveus (st. O‐A) inhibitory interneurones of neonatal rat CA1 hippocampal slices were determined using whole‐cell patch clamp techniques. 2. 4‐Aminopyridine dose‐dependently prolonged the action potential repolarization. The effects of 4‐AP persisted in Ca(2+)‐free conditions. Action potentials evoked from hyperpolarized potentials possessed an increased rate of repolarization. These data suggest an involvement of the rapidly activating transient current, IA, in spike repolarization. 3. Action potential duration was increased in the presence of Ca(2+)‐free, Cd(2+)‐containing solution, iberiotoxin or 1 mM TEA. The fast component of the AHP was attenuated by these agents suggesting that the Ca(2+)‐activated K+ conductance, IC, underlies both the spike repolarization and fast AHP. 4. In Ca(2+)‐free conditions, TEA (> 1 mM) dose‐dependently prolonged the action potential duration by blocking a late conductance in action potential repolarization, suggesting a role for the sustained current, IK. 5. The slow AHP was attenuated by Ca(2+)‐free medium, apamin or the Ca2+ chelator EGTA, suggesting a role for the Ca(2+)‐activated K+ conductance, IAHP. 6. We conclude that action potential repolarization and AHP of st. O‐A interneurones result from the activation of pharmacologically distinct, temporally overlapping potassium conductances. These findings are discussed with reference to the voltage clamp data presented in the preceding manuscript.
Barrier disruption increases gene expression of cytokines and the 55 kD TNF receptor in murine skin

Abstract The signalling mechanisms that regulate epidermal permeability barrier homeostasis arc not known. Previous Northern blot analysis showed that both acute and chronic barrier disruption increase mRNA levels of several cytokines in murine epidermis. To further characterize the epidermal response to barrier abrogation, we used more sensitive, multi‐probe RNasc protection assays to measure the mRNA levels of additional cytokines. as well as cytokine receptors in acute and chronic models of barrier disruption. Normal mouse epidermis expressed interleukin (IL)‐lα, interferon‐γ (IFN‐γ). tumor necrosis factor‐α (TNF‐α) and IL‐6 mRNAs. Following tape‐stripping, only the mRNA levels for TNF‐α, IL‐lα, IL‐lβ and IL‐6 increased at 2.5 and 7 h, and returned toward normal levels by IX h. No mRNAs encoding TNF‐β. IL‐2, IL‐3. IL‐4 or IL‐5, were detected in the epidermis either under basal conditions or after tape‐stripping. Similarly, in a chronic model, essential fatty acid deficiency, epidermal levels of TNF‐α, IL‐lα, IL‐lβ and IL‐6 mRNAs, but not IFN‐γ mRNA. were elevated over controls; and again, mRNAs for the remaining probed cytokines were not detected. In contrast, in the dermis. only IL‐Iβ mRNA levels increased 2.5 h after tape‐stripping, and remained elevated at I8 h. mRNAs encoding the IL‐1 (p60), IFN‐γ ami IL‐6 receptors were present in epidermis, but their levels remained unchanged following either acute or chronic barrier disruption. In contrast, epidermal TNF (p55) receptor mRNA levels were increased by 87% (P<0.01) at 2.5 h, returned to control levels at 7 h and were increased by 68% (p<0.03) at 18 h after tape‐stripping. The increase at 2 h was confirmed by Northern blot analysis and was not prevented by latex occlusion performed immediately after tape‐stripping. mRNAs for the IL‐I (p80) receptor and TNF (p75) receptor were not detected in epidermis. Low levels of TNF (p55) receptor mRNA were present in the dermis. and they remained unchanged after tape‐stripping. The presence of specific receptor mRNAs in the epidermis and dermis suggests that these tissues are capable of responding in an autocrine and/or paracrine fashion to the cognate cytokines. These results suggest that epidermal cytokines produced after barrier disruption may initiate a cytokine cascade which could regulate cytokine and cytokine receptor production and/or inflammatory responses.