Miracle-dz/UniFAR-FTUs huggingface dataset:
Why we evaluate: Functions of attitudes.

As the first book to examine the psychological motivations underlying people's attitudes, as well as why people form attitudes, this volume presents empirical research describing theoretical perspectives and practical applications. The editors assembled the leaders in the field to examine the topics of attitude function persuasion, individual-differences approaches, and the role of motivation within a variety of psychological disciplines, including social, personality, consumer, and environmental.
Cardiovascular Changes During Maturation and Ageing in Male and Female Spontaneously Hypertensive Rats

Background: Cardiovascular remodeling leading to heart failure is common in the elderly. Testing effective pharmacological treatment of human heart failure requires a suitable animal model that adequately mimics the human disease state. Methods: This study has characterized the structural, functional, and electrical characteristics of the cardiovascular system throughout the lifespan in male and female spontaneously hypertensive rats (SHRs), a genetic model of chronic hypertension-induced cardiovascular remodeling, and age- and gender-matched normotensive controls, to determine whether ageing SHRs mimic the changes seen in ageing humans. Results: Both the ageing male and female SHRs developed progressive hypertension, ventricular hypertrophy, left ventricular fibrosis, action potential prolongation without impaired glucose tolerance. Male SHRs from 15 months of age exhibited left ventricular wall thinning and chamber dilation, together with systolic and diastolic dysfunction and increased cardiac stiffness and increased erythrocyte superoxide production, which were not present in the female SHRs. Conclusion: Ageing male SHRs in contrast to the female SHRs, better mimic the chronic heart failure in humans produced by chronic hypertension. Ageing male SHRs could then be used to investigate proposed therapeutic interventions for chronic congestive heart failure in humans.
Transcription factor GATA-4 regulates cardiac muscle-specific expression of the alpha-myosin heavy-chain gene

The alpha-myosin heavy-chain (alpha-MHC) gene is the major structural protein in the adult rodent myocardium. Its expression is restricted to the heart by a complex interplay of trans-acting factors and their cis-acting sites. However, to date, the factors that have been shown to regulate expression of this gene have also been found in skeletal muscle cells. Recently, transcription factor GATA-4, which has a tissue distribution limited to the heart and endodermally derived tissues, was identified. We recently found two putative GATA-binding sites within the proximal enhancer of the alpha-MHC gene, suggesting that GATA-4 might regulate its expression. In this study, we establish that GATA-4 interacts with the alpha-MHC GATA sites to stimulate cardiac muscle-specific expression. Mutation of the GATA-4-binding sites either individually or together decreased activity by 50 and 88% in the adult myocardium, respectively. GATA-4-dependent enhancement of activity from a heterologous promoter was mediated through the alpha-MHC GATA sites. Coinjection of an alpha-MHC promoter construct with a GATA-4 expression vector permitted ectopic expression in skeletal muscle but not in fibroblasts. Thus, the lack of alpha-MHC expression in skeletal muscle correlates with a lack of GATA-4. GATA-4 DNA binding activity was significantly up-regulated in triiodothyronine- or retinoic acid-treated cardiomyocytes. Putative GATA-4-binding sites are also found in the regulatory regions of other cardiac muscle-expressed structural genes. This indicates a mechanism whereby triiodothyronine and retinoic acid can exert coordinate control of the cardiac phenotype through a trans-acting regulatory factor.
Time trends in pulmonary embolism in the United States: evidence of overdiagnosis.

BACKGROUND Computed tomographic pulmonary angiography (CTPA) may improve detection of life-threatening pulmonary embolism (PE), but this sensitive test may have a downside: overdiagnosis and overtreatment (finding clinically unimportant emboli and exposing patients to harms from unnecessary treatment). METHODS To assess the impact of CTPA on national PE incidence, mortality, and treatment complications, we conducted a time trend analysis using the Nationwide Inpatient Sample and Multiple Cause-of-Death databases. We compared age-adjusted incidence, mortality, and treatment complications (in-hospital gastrointestinal tract or intracranial hemorrhage or secondary thrombocytopenia) of PE among US adults before (1993-1998) and after (1998-2006) CTPA was introduced. RESULTS Pulmonary embolism incidence was unchanged before CTPA (P = .64) but increased substantially after CTPA (81% increase, from 62.1 to 112.3 per 100,000; P < .001). Pulmonary embolism mortality decreased during both periods: more so before CTPA (8% reduction, from 13.4 to 12.3 per 100,000; P < .001) than after (3% reduction, from 12.3 to 11.9 per 100,000; P = .02). Case fatality improved slightly before (8% decrease, from 13.2% to 12.1%; P = .02) and substantially after CTPA (36% decrease, from 12.1% to 7.8%; P < .001). Meanwhile, CTPA was associated with an increase in presumed complications of anticoagulation for PE: before CTPA, the complication rate was stable (P = .24), but after it increased by 71% (from 3.1 to 5.3 per 100,000; P < .001). CONCLUSIONS The introduction of CTPA was associated with changes consistent with overdiagnosis: rising incidence, minimal change in mortality, and lower case fatality. Better technology allows us to diagnose more emboli, but to minimize harms of overdiagnosis we must learn which ones matter.
Analyzing moral hazard behaviors of non-environmental pollution agri-product producers under the government regulation—based on a survey of rural households in Jiangsu

To control the quality of agricultural products one must manage from the production headstream.Using the empirical method and the survey data of 331 non-environmental pollution agricultural product producers in Jiangsu,the authors studied the moral hazard behavior of the producers.The results indicate that some of the producers of non-environmental pollution agricultural product didn't operate in accordance with the standard for non-environmental pollution production.The factors influencing the producers of non-environmental pollution agricultural product include the sex,the family configuration,the planting areas,the proportion of non-environmental pollution agricultural product income,the quality control education,the agricultural cooperate organization,the degree of commodity,the concern over food safety,and the awareness of monitoring and punishment due to disobeying the standard.
Rosette-forming Glioneuronal Tumour of the Fourth Ventricle with Previous Intratumoural Haemorrhage: Case Report and Review of the Literature

The case is reported of a rosette-forming glioneuronal tumour of the fourth ventricle (RGTFV) in a 27-year-old male. Symptoms included headache, severe vomiting and clumsy walking that had progressively worsened over 14 days. Computed tomography and magnetic resonance imaging indicated a 3.0 × 2.5 × 2.0 cm solid-cystic mass in the fourth ventricle and obstructive hydrocephalus. The tumour showed evidence of previous intra-tumour haemorrhage, with heterogeneous enhancement after contrast administration. Complete excision of the lesion was performed. Signs of previous intra-tumoural haemorrhage were seen intra-operatively. The detailed clinical, radiological and pathological features in this patient are described and compared with existing literature on this type of tumour. Despite benign histological features and a reported favourable post-operative course, there is still limited clinical experience with this type of tumour, however intratumoural haemorrhage may result in morbidity and mortality. This report will help provide better characterization of this entity, improving the diagnosis and potentially reducing mortality in RGTFV.
Gender and Intimate Partner Violence

Research on Intimate Partner Violence (IPV) has ignited considerable controversy about gender and IPV. Feminist scholars have viewed IPV as a manifestation of male dominance and control, with women primarily the victims and men primarily the perpetrators of this behavior (gender asymmetry). Conversely, family violence researchers have viewed IPV as emerging from conflicts in relationships, with both men and women being involved (gender symmetry). The present study was framed within the context of this controversy using new empirical evidence on one person arrested (single arrest) or both persons arrested (dual arrest) in IPV incidents. Data were acquired on the assessed risk of IPV recidivism immediately after arrest and actual IPV recidivism over an 18-month period postassessment across the state of Connecticut involving heterosexual partners (N = 2,155). Though not definitive, the findings showed persistent gender asymmetry on these behavioral characteristics across arrest categories.
The Course of the Inferior Alveolar Nerve in the Normal Human Mandibular Ramus and in Patients Presenting for Cosmetic Reduction of the Mandibular Angles

This study was undertaken to quantify the path of the inferior alveolar nerve in the normal human mandible and in the mandibles of patients presenting for cosmetic reduction of the mandibular angles. The goals were: (1) to provide normative information that would assist the surgeon in avoiding injury to the nerve during surgery; (2) to characterize gender differences in the normal population; and (3) to compare the course of the nerve in the normal population to its course in a group of patients who presented with a complaint of “square face. ” The study was based upon the computerized tomographic scans of 10 normal patients (six men, four women) and 8 patients (all women) complaining of “square face. ” Using AnalyzePC 2.5 imaging software, the mandibles were segmented and the position of the nerve was recorded within its osseous canal in the mandibular ramus on each axial slice in which it was identifiable. Distances were calculated between the nerve and the anterior, posterior, lateral, and medial cortices. The positions of the lateral ramus prominence and the lowest point on the sigmoid notch were also recorded. The position of the mental foramen was recorded in relation to the nearest tooth, and the three-dimensional surface distances from the foramen to the alveolar bone, the inferior border of the mandible, and the mandibular symphysis were determined. The distances from the entrance of the nerve into the mandible to the lateral ramus prominence and the lowest point on the sigmoid notch were calculated. Summary statistics were obtained, comparing differences in gender. The nerve was identifiable in each ramus over a mean distance of 12.7 mm. On average, the lateral ramus prominence was 0.3 mm higher on the caudad-cephalad axis than the point at which the nerve entered the bone, whereas the location of the lowest point on the sigmoid notch was 16.6 mm above the nerve. The average distances from the nerve to the anterior, posterior, medial, and lateral cortices were 11.6, 12.1, 1.8, and 4.7 mm, respectively. Gender differences were significant for all of these except the medial cortex to nerve distance. On average, the mental foramen exited the body of the mandible immediately below the second premolar and the average surface distances from the foramen to the symphysis, the most cephalad alveolar bone, and the inferior border of the body were 30.9, 14.2, and 19.3 mm, respectively. With regard to the patients presenting for mandibular angle reduction, there were a few statistically significant but small scalar differences from normal controls.
Caprine arthritis-encephalitis in an indigenous Spanish breed of dairy goat

The presence of caprine arthritis and encephalitis (CAE) in Spain has never been officially acknowledged but it is suspected. Goats have been imported from other European countries with a high prevalence of the disease, mainly France, and they might have introduced the disease into the indigenous goat population. A serological survey of caprine arthritis and encephalitis virus antibodies was carried out in 22 volunteer dairy Murciano-Granadina goat herds; 2513 lactating goats were tested with an agar gel immunodiffusion test, and 12.1 per cent were found to be positive. Five of the herds were free of infection, six had a low prevalence of the disease, five had a medium prevalence and six had a high prevalence. Five seropositive goats with clinical signs of CAE were studied. Macroscopic and microscopic lesions similar to those described for CAE were detected in all five goats and a cytopathic effect typical of CAE virus was observed in primary explant cultures from four of them.
Octopamine immunoreactive cell populations in the locust thoracic‐abdominal nervous system

We describe octopamine‐immunoreactive somata and their projections in the pro‐ meso‐, meta‐ and pregenital abdominal‐ganglia of locusts. Immunoreactive midline somata were identified as dorsal‐ and ventral‐ unpaired median (DUM‐ and VUM‐, respectively) neurones due to their: characteristic large size and positions of somata, primary neurites in DUM‐tracts giving rise to T‐junctions, and bilaterally projecting axons. In the prothoracic ganglion there are most likely 8 such cells; in the meso‐ and metathoracic, some 20 each; and in each individual pregenital abdominal ganglion, typically 3. All appear to project to peripheral nerves and their numbers correspond to the number of peripherally projecting DUM‐cells identified to date in each ganglion. We suggest that probably all peripherally projecting DUM‐cells are octopaminergic in the examined ganglia. Presumptive DUM‐interneurones are not octopamine‐immunoreactive, but, confirming other studies, are shown to label with an antiserum to γ‐amino butyric acid (GABA).
Precise modelling of switching and conduction losses in cascaded h-bridge multilevel inverters

Nowadays, voltage source multilevel inverters are being used extensively in industry due to its many advantages, compared to conventional two level inverters, such as higher output voltage at low switching frequency, low voltage stress(dv/dt), lower total harmonic distortion (THD), less electro-magnetic interference (EMI), smaller output filter and higher fundamental output. However, the evaluation of multilevel inverter losses is much more complicated compared to two level inverters. This paper proposes an on-line model for precise calculation of conduction and switching losses for cascaded h-bridge multilevel inverter. The model is simple and efficient and gives clear process of loss calculation. A single phase, 7-level cascaded H-bridge with IGBT's as switching devices has been used as a case study of the proposed model. The inverter has been controlled using selective harmonic elimination in which the switching angles were determined using the Genetic Algorithm (GA). MATLAB-SIMULINK is used for the modelling and simulation.
P‐Selectin Sustains Extramedullary Hematopoiesis in the Gata1low Model of Myelofibrosis

Splenomegaly is a major manifestation of primary myelofibrosis (PMF) contributing to clinical symptoms and hematologic abnormalities. The spleen from PMF patients contains increased numbers of hematopoietic stem cells (HSC) and megakaryocytes (MK). These MK express high levels of P‐selectin (P‐sel) that, by triggering neutrophil emperipolesis, may cause TGF‐β release and disease progression. This hypothesis was tested by deleting the P‐sel gene in the myelofibrosis mouse model carrying the hypomorphic Gata1low mutation that induces megakaryocyte abnormalities that recapitulate those observed in PMF. P‐selnullGata1low mice survived splenectomy and lived 3 months longer than P‐selWTGata1low littermates and expressed limited fibrosis and osteosclerosis in the marrow or splenomegaly. Furthermore, deletion of P‐sel disrupted megakaryocyte/neutrophil interactions in spleen, reduced TGF‐β content, and corrected the HSC distribution that in Gata1low mice, as in PMF patients, is abnormally expanded in spleen. Conversely, pharmacological inhibition of TGF‐β reduced P‐sel expression in MK and corrected HSC distribution. Spleens, but not marrow, of Gata1low mice contained numerous cKITpos activated fibrocytes, probably of dendritic cell origin, whose membrane protrusions interacted with MK establishing niches hosting immature cKITpos hematopoietic cells. These activated fibrocytes were not detected in spleens from P‐selnullGata1low or TGF‐β‐inhibited Gata1low littermates and were observed in spleen, but not in marrow, from PMF patients. Therefore, in Gata1low mice, and possibly in PMF, abnormal P‐sel expression in MK may mediate the pathological cell interactions that increase TGF‐β content in MK and favor establishment of a microenvironment that supports myelofibrosis‐related HSC in spleen. Stem Cells 2016;34:67–82
Characterizing the human-robot haptic dyad in robot therapy of stroke survivors

– The working hypothesis, on which this paper is built, is that it is advantageous to look at protocols of robot rehabilitation in the general context of human-robot interaction in haptic dyads. The purpose of this paper is to propose a new method to detect and evaluate an index of active participation (AC index), underlying the performance of robot-assisted movements. This is important for avoiding the slacking phenomenon that affects robot therapy. , – The evaluation of the AC index is based on a novel technique of assistance which does not use constant or elastic forces but trains of small force impulses, with amplitude adapted to the level of impairment and a frequency of 2 Hz, which is suggested by recent results in the field of intermittent motor control. A preliminary feasibility test of the proposed method was carried out during a haptic reaching task in the absence of visual feedback, for a group of five stroke patients and an equal group of healthy subjects. , – The AC index appears to be stable and sensitive to training in both populations of subjects. , – The main original element of this study is the proposal of the new AC index of voluntary control associated with the new method of pulsed haptic interaction.
Borrelia burgdorferi OspC Protein Required Exclusively in a Crucial Early Stage of Mammalian Infection

ABSTRACT This study demonstrates a strict temporal requirement for a virulence determinant of the Lyme disease spirochete Borrelia burgdorferi during a unique point in its natural infection cycle, which alternates between ticks and small mammals. OspC is a major surface protein produced by B. burgdorferi when infected ticks feed but whose synthesis decreases after transmission to a mammalian host. We have previously shown that spirochetes lacking OspC are competent to replicate in and migrate to the salivary glands of the tick vector but do not infect mice. Here we assessed the timing of the requirement for OspC by using an ospC mutant complemented with an unstable copy of the ospC gene and show that B. burgdorferi's requirement for OspC is specific to the mammal and limited to a critical early stage of mammalian infection. By using this unique system, we found that most bacterial reisolates from mice persistently infected with the initially complemented ospC mutant strain no longer carried the wild-type copy of ospC. Such spirochetes were acquired by feeding ticks and migrated to the tick salivary glands during subsequent feeding. Despite normal behavior in ticks, these ospC mutant spirochetes did not infect naive mice. ospC mutant spirochetes from persistently infected mice also failed to infect naive mice by tissue transplantation. We conclude that OspC is indispensable for establishing infection by B. burgdorferi in mammals but is not required at any other point of the mouse-tick infection cycle.
Marked ancestor problems

Consider a rooted tree whose nodes can be in two states: marked or unmarked. The marked ancestor problem is to maintain a data structure with the following operations: mark(v) marks node v: unmark(v) removes any marks from node v; firstmarked(v) returns the first marked node on the path from v to the root. We show tight upper and lower bounds for the marked ancestor problem. The lower bounds are proved in the cell probe model, the algorithms run on a unit-cost RAM. As easy corollaries we prove (often optimal) lower bounds on a number of problems. These include planar range searching, including the existential or emptiness problem, priority search trees static tree union-find, and several problems from dynamic computational geometry, including segment intersection, interval maintenance, and ray shooting in the plane. Our upper bounds improve algorithms from various fields, including coloured ancestor problems and maintenance of balanced parentheses.
Decreasing pfmdr1 Copy Number Suggests that Plasmodium falciparum in Western Cambodia Is Regaining In Vitro Susceptibility to Mefloquine

ABSTRACT Dihydroartemisinin-piperaquine is the current frontline artemisinin combination therapy (ACT) for Plasmodium falciparum malaria in Cambodia but is now failing in several western provinces. To investigate artesunate plus mefloquine (AS+MQ) as a replacement ACT, we measured the prevalence of multiple pfmdr1 copies—a molecular marker for MQ resistance—in 844 P. falciparum clinical isolates collected in 2008 to 2013. The pfmdr1 copy number is decreasing in Western Cambodia, suggesting that P. falciparum is regaining in vitro susceptibility to MQ.
Comprehensive Circuit Model of Autolimiting Superconductor Devices

This paper presents a phenomenological equivalent circuit to model the phenomenon occurring when a section of superconducting transmission line transits from a superconducting state to a normal state. This phenomenon allows the use of superconductors for the design of autolimiting structures based on superconducting transmission line sections. Although this autolimiting effect happens when the current density achieved in the superconductor exceeds the critical current inherent to the superconducting material, heating effects also play a significant role in this behavior. The equivalent circuit presented in this work accounts for both electric and thermal effects, and the interaction between them. The circuit model is then used for the evaluation of a practical microwave and frequency selective IMUX configuration.
The Basis for a Second-generation Highly Cross-linked UHMWPE

Highly cross-linked ultra-high molecular weight polyethylene (UHMWPE) decreases wear at the hip by more than 50% compared with conventional UHMWPE. However, melted highly cross-linked polyethylene may be susceptible to fatigue cracking, and annealed highly cross-linked polyethylene may be susceptible to in vivo oxidation. The second-generation highly cross-linked UHMWPE (X3 HXPE) uses a sequential irradiation and annealing process. It preserves mechanical strength properties and has the highest survivorship in functional fatigue testing. The free radical content is low, and its performance under accelerated aging is the same as virgin UHMWPE. Hip simulator studies with 32-mm acetabular components demonstrated 97% wear reduction compared with conventional UHMWPE, and 62% compared with a clinically successful first-generation annealed highly cross-linked polyethylene. The crystallinity, density, and tensile strength of the X3 HXPE material was unchanged by oxidative challenge. X3 HXPE material articulating on cobalt-chromium alloy yields a volumetric wear rate very similar to that of metal-on-metal articulations, but eliminates the concerns of metal ion release. Wear particles generated from the X3 HXPE were the same size as those produced from conventional UHMWPE. Preliminary results suggest X3 HXPE can be used for cups larger than 36 mm.