Miracle-dz/UniFAR-FTUs huggingface dataset:
Cingulo‐opercular adaptive control for younger and older adults during a challenging gap detection task

Cingulo‐opercular activity is hypothesized to reflect an adaptive control function that optimizes task performance through adjustments in attention and behavior, and outcome monitoring. While auditory perceptual task performance appears to benefit from elevated activity in cingulo‐opercular regions of frontal cortex before stimuli are presented, this association appears reduced for older adults compared to younger adults. However, adaptive control function may be limited by difficult task conditions for older adults. An fMRI study was used to characterize adaptive control differences while 15 younger (average age = 24 years) and 15 older adults (average age = 68 years) performed a gap detection in noise task designed to limit age‐related differences. During the fMRI study, participants listened to a noise recording and indicated with a button‐press whether it contained a gap. Stimuli were presented between sparse fMRI scans (TR = 8.6 s) and BOLD measurements were collected during separate listening and behavioral response intervals. Age‐related performance differences were limited by presenting gaps in noise with durations calibrated at or above each participant's detection threshold. Cingulo‐opercular BOLD increased significantly throughout listening and behavioral response intervals, relative to a resting baseline. Correct behavioral responses were significantly more likely on trials with elevated pre‐stimulus cingulo‐opercular BOLD, consistent with an adaptive control framework. Cingulo‐opercular adaptive control estimates appeared higher for participants with better gap sensitivity and lower response bias, irrespective of age, which suggests that this mechanism can benefit performance across the lifespan under conditions that limit age‐related performance differences.
Quasi Similar Routes of NO2 and NO Sensing by Nanocrystalline WO3: Evidence by In Situ DRIFT Spectroscopy

Tungsten oxide is a renowned material for resistive type gas sensors with high sensitivity to nitrogen oxides. Most studies have been focused on sensing applications of WO3 for the detection of NO2 and a sensing mechanism has been established. However, less is known about NO sensing routes. There is disagreement on whether NO is detected as an oxidizing or reducing gas, due to the ambivalent redox behavior of nitric oxide. In this work, nanocrystalline WO3 with different particle size was synthesized by aqueous deposition of tungstic acid and heat treatment. A high sensitivity to NO2 and NO and low cross-sensitivities to interfering gases were established by DC-resistance measurements of WO3 sensors. Both nitrogen oxides were detected as the oxidizing gases. Sensor signals increased with the decrease of WO3 particle size and had similar dependence on temperature and humidity. By means of in situ infrared (DRIFT) spectroscopy similar interaction routes of NO2 and NO with the surface of tungsten oxide were unveiled. Analysis of the effect of reaction conditions on sensor signals and infrared spectra led to the conclusion that the interaction of WO3 surface with NO was independent of gas-phase oxidation to NO2.
Treatment interventions for hand fractures and joint injuries: a scoping review of randomized controlled trials

The aim of this study was to identify and assess all existing randomized studies on treatment interventions for hand fractures and joint injuries, to inform practice and plan future research. PubMed, Cochrane CENTRAL, MEDLINE and Embase were searched. We identified 78 randomized controlled trials published over 35 years, covering seven anatomical areas of the hand. We report on sources of bias, sample size, follow-up length and retention, outcome measures and reporting. In terms of interventions studied, the trials were extremely heterogeneous, so it is difficult to draw conclusions on individual treatments. The published randomized controlled clinical trial evidence for hand fractures and joint injuries is narrow in scope and of generally low methodological quality. Mapping provides a useful resource and stepping-stone for planning further research. There is a need for high-quality, collaborative research to guide management of a wider range of common hand injuries.
Hand Hygiene Practice Among Health Care Workers in a Tertiary Hospital in Sub-Saharan Africa (Handy Study).

BACKGROUND Hand hygiene (HH) practices are emphasized as the single most important way of reducing HealthCare-Associated Infection (HCAIs). This study was done to assess the compliance with hand hygiene and knowledge about standard HH practices by health care workers as well as to assess the availability of HH materials in the largest tertiary Hospital in Nigeria. METHODS A cross-sectional, observational study involving consecutive observations during routine patient care in various units of the University College Hospital (UCH), Ibadan; using a checklist and compliance forms adapted from the WHO guidelines was done. HH knowledge scores were categorized as < 4 = poor, 4-6=fair and >7 = good. RESULTS A total of 559 HH opportunities were identified and overall compliance was 30.4% (170/ 559). Compliance differed by units: Neonatology SCBU (68.2%), Intensive Care Unit (41.8%), Obstetrics & Gynaecology (39.4%), Adult emergency (26.7%), Children emergency (24.6%), Medicine (22.4%), Surgery (14.9%) and Paediatrics (12.8%). Nurses were more likely to practice hand hygiene (33.2%) compared to doctors (29.0%) [c2 = 33.270, CI= 95%, P<0.001]. Female HCWs had higher hand hygiene compliance (30.6% vs. 25.4%) [c2= 2.129, CI= 95%, P= 0.345]. Soap and water were employed more (95.5%) compared to alcohol-based hand rub (4.5%). Only 12.1% had good HH knowledge scores (>7). CONCLUSION Poor HH compliance is observed at the facility and is attributable to inadequate education, poor knowledge of standard HH practices and unavailability of HH materials in most of the units. A multidimensional approach is advocated to tackle these issues.
Tuberculosis Diagnosis in Children Using Xpert Ultra on Different Respiratory Specimens.

RATIONALE Microbiological confirmation of pulmonary tuberculosis in children is desirable. OBJECTIVES To investigate the diagnostic accuracy and incremental yield of Xpert-Ultra, a new rapid test, on repeated induced sputum, nasopharyngeal aspirates and combinations of specimens. METHODS Consecutive South African children hospitalized with suspected pulmonary tuberculosis were enrolled. MEASUREMENTS Induced sputum and nasopharyngeal aspirates were obtained. Nasopharyngeal aspirates were frozen; induced sputum underwent liquid culture, an aliquot was frozen. Ultra was performed on thawed nasopharyngeal aspirates and induced sputum specimens individually. Children were categorised as confirmed, unconfirmed or unlikely tuberculosis according to NIH consensus case definitions. The diagnostic accuracy of Ultra was compared with liquid culture on induced sputum. MAIN RESULTS 195 children [median age 23·3 months, 32(16·4%) HIV-infected] had one induced sputum and nasopharyngeal aspirate; 130 had two nasopharyngeal aspirates. There were 40(20·5%) culture confirmed cases. Ultra was positive on nasopharyngeal aspirates in 26(13·3%) and on induced sputum in 31(15·9%). Sensitivity and specificity of Ultra on one nasopharyngeal-aspirate were 46% and 98% respectively, similar by HIV status. Sensitivity and specificity of Ultra on one induced sputum were 74·3% and 96·9% respectively. Combining one nasopharyngeal aspirate and one induced sputum increased sensitivity to 80%. Sensitivity using Ultra on two nasopharyngeal aspirates was 54.2%, increasing to 87.5% with an induced sputum Ultra. CONCLUSIONS Induced sputum provides a better specimen than repeated nasopharyngeal aspirate for rapid diagnosis using Ultra. However, Ultra testing of combinations of specimens provides a novel strategy that can be adapted to identify most children with confirmed pulmonary tuberculosis.
How to Obtain a Reliable Estimate of Occupational Exposure? Review and Discussion of Models’ Reliability

Evaluation and validation studies of quantitative exposure models for occupational exposure assessment are still scarce and generally only consider a limited number of exposure scenarios. The aim of this review was to report the current state of knowledge of models’ reliability in terms of precision, accuracy, and robustness. A systematic review was performed through searches of major scientific databases (Web of Science, Scopus, and PubMed), concerning reliability of Tier1 (“ECETOC TRA”-European Centre for Ecotoxicology and Toxicology of Chemicals Targeted Risk Assessment, MEASE, and EMKG-Expo-Tool) and Tier2 models (STOFFENMANAGER® and “ART”-Advanced Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) Tool). Forty-five studies were identified, and we report the complete information concerning model performance in different exposure scenarios, as well as between-user reliability. Different studies describe the ECETOC TRA model as insufficient conservative to be a Tier1 model, in different exposure scenarios. Contrariwise, MEASE and EMKG-Expo-Tool seem to be conservative enough, even if these models have not been deeply evaluated. STOFFENMANAGER® resulted the most balanced and robust model. Finally, ART was generally found to be the most accurate and precise model, with a medium level of conservatism. Overall, the results showed that no complete evaluation of the models has been conducted, suggesting the need for correct and harmonized validation of these tools.
Unmet Needs in Ophthalmology: A European Vision Institute-Consensus Roadmap 2019–2025

Purpose: To define unmet needs in ophthalmology that can realistically be addressed in the next 5 years (2019–2025) and describe potential avenues for research to address these challenges. Methods: Outcomes of a consensus process within the European Vision institute (Brussels) are outlined. Disease areas that are discussed comprise glaucoma, retinal dystrophies, diabetic retinopathy, dry eye disease, corneal diseases, cataract and refractive surgery. Results: Unmet needs in the mentioned disease areas are discussed and realistically achievable research projects outlined. Conclusions: Considerable progress can be made in the ophthalmic field and patient-relevant outcomes in the near future.
Stabilization of Human Multidrug Resistance Protein 4 (MRP4/ABCC4) Using Novel Solubilization Agents

Membrane proteins (MPs) are important drug discovery targets for a wide range of diseases. However, elucidating the structure and function of native MP is notoriously challenging as their original structure has to be maintained once removed from the lipid bilayer. Conventionally, detergents have been used to solubilize MP with varying degrees of success concerning MP stability. To try to address this, new, more stabilizing agents have been developed, such as calixarene-based detergents and styrene–maleic acid (SMA) copolymer. Calixarene-based detergents exhibit enhanced solubilizing and stabilizing properties compared with conventional detergents, whereas SMA is able to extract MPs with their surrounding lipids, forming a nanodisc structure. Here we report a comparative study using classical detergents, calixarene-based detergents, and SMA to assess the solubilization and stabilization of the human ABC transporter MRP4 (multidrug resistance protein 4/ABCC4). We show that both SMA and calixarene-based detergents have a higher solubility efficiency (at least 80%) than conventional detergents, and show striking overstabilization features of MRP4 (up to 70 °C) with at least 30 °C stability improvement in comparison with the best conventional detergents. These solubilizing agents were successfully used to purify aggregate-free, homogenous and stable MRP4, with sevenfold higher yield for C4C7 calixarene detergent in comparison with SMA. This work paves the way to MRP4 structural and functional investigations and illustrates once more the high value of using calixarene-based detergent or SMA as versatile and efficient tools to study MP, and eventually enable drug discovery of challenging and highly druggable targets.
Application of the Theory of Planned Behavior in Environmental Science: A Comprehensive Bibliometric Analysis

Since the theory of planned behavior (TPB) was proposed by Ajzen in 1985, it has attracted extensive interest and been widely applied worldwide. Although an increasing number of studies have employed the TPB in the domain of environmental science, there have been no attempts to retrospectively analyze existing articles. The current study aimed to holistically understand the application status of the TPB in environmental science from a knowledge domain visualization perspective. A total of 531 journal articles were obtained through the Scopus database to perform a bibliometric analysis and content analysis. The results showed that waste management, green consumption, climate and environment, saving and conservation, and sustainable transportation are the primary research topics; the United States (U.S.), Mainland China, the United Kingdom (UK), and Malaysia are the most productive countries/regions. Moreover, the cross-disciplinary situations, main source journals, and key articles were revealed. Furthermore, the extended factors, integrated theories, major methods, specific groups, and control variables of environmental science research using the TPB were elaborated and integrated into a comprehensive application framework. Constructive criticisms were ultimately discussed. The findings contribute in several ways to help relevant researchers learn about the application of TPB to environmental science and provide new insights and holistic references for further research on environment-related behavior.
The Influence of Aging in Solvents on Dental Cements Hardness and Diametral Tensile Strength

Prosthetic materials must exhibit adequate resistance to the oral environment. The aim of this paper was to study the resistance of selected cements used for cementing restorations (Breeze—composite, Adhesor Carbofine—zinc-polycarboxylate and IHDENT–Giz type II—glass-ionomer) against ethanol, soda and green tea solutions. The highest values of hardness and DTS (diametral tensile strength) were obtained by composite cement (HV = 15–31, DTS = 34–45 MPa). Ethanol solution had the greatest impact on the hardness value of composite cement, and soda solution on zinc-polycarboxylate cement. No significant differences were noted in the DTS values of composite cements after immersion in solvents; however, the DTS value of zinc-polycarboxylate cement increased after prolonged immersion time in ethanol and the DTS of glass-ionomer cement (IHDENT Giz type II) clearly decreased after submersion in soda solutions. Variation in pH across the range of 6 (tea) to 9 (soda solution) had a low impact on the properties of dental cements. Extended exposure to solvents appears to worsen the properties of cements.
Assessing and Managing the Metabolic Syndrome in Children and Adolescents

The metabolic syndrome (MetS) is a group of cardiovascular risk factors that are associated with insulin resistance and are driven by underlying factors, including visceral obesity, systemic inflammation, and cellular dysfunction. These risks increasingly begin in childhood and adolescence and are associated with a high likelihood of future chronic disease in adulthood. Efforts should be made at both recognition of this metabolic risk, screening for potential associated Type 2 diabetes, and targeting affected individuals for appropriate treatment with an emphasis on lifestyle modification. Effective interventions have been linked to reductions in MetS—and in adults, reductions in the severity of MetS have been linked to reduced diabetes and cardiovascular disease.
Intergeneric Relationships within the Family Salicaceae s.l. Based on Plastid Phylogenomics

Many Salicaceae s.l. plants are recognized for their important role in the production of products such as wood, oils, and medicines, and as a model organism in life studies. However, the difference in plastid sequence, phylogenetic relationships, and lineage diversification of the family Salicaceae s.l. remain poorly understood. In this study, we compare 24 species representing 18 genera of the family. Simple sequence repeats (SSRs) are considered effective molecular markers for plant species identification and population genetics. Among them, a total of 1798 SSRs were identified, among which mononucleotide repeat was the most common with 1455 accounts representing 80.92% of the total. Most of the SSRs are located in the non-coding region. We also identified five other types of repeats, including 1750 tandems, 434 forward, 407 palindromic, 86 reverse, and 30 complementary repeats. The species in Salicaceae s.l. have a conserved plastid genome. Each plastome presented a typical quadripartite structure and varied in size due to the expansion and contraction of the inverted repeat (IR) boundary, lacking major structural variations, but we identified six divergence hotspot regions. We obtained phylogenetic relationships of 18 genera in Salicaceae s.l. and the 24 species formed a highly supported lineage. Casearia was identified as the basal clade. The divergence time between Salicaceae s.l. and the outgroup was estimated as ~93 Mya; Salix, and Populus diverged around 34 Mya, consistent with the previously reported time. Our research will contribute to a better understanding of the phylogenetic relationships among the members of the Salicaceae s.l.
Integrative analysis of gene expression and DNA methylation through one‐class logistic regression machine learning identifies stemness features in medulloblastoma

Most human cancers develop from stem and progenitor cell populations through the sequential accumulation of various genetic and epigenetic alterations. Cancer stem cells have been identified from medulloblastoma (MB), but a comprehensive understanding of MB stemness, including the interactions between the tumor immune microenvironment and MB stemness, is lacking. Here, we employed a trained stemness index model based on an existent one‐class logistic regression (OCLR) machine‐learning method to score MB samples; we then obtained two stemness indices, a gene expression‐based stemness index (mRNAsi) and a DNA methylation‐based stemness index (mDNAsi), to perform an integrated analysis of MB stemness in a cohort of primary cancer samples (n = 763). We observed an inverse trend between mRNAsi and mDNAsi for MB subgroup and metastatic status. By applying the univariable Cox regression analysis, we found that mRNAsi significantly correlated with overall survival (OS) for all MB patients, whereas mDNAsi had no significant association with OS for all MB patients. In addition, by combining the Lasso‐penalized Cox regression machine‐learning approach with univariate and multivariate Cox regression analyses, we identified a stemness‐related gene expression signature that accurately predicted survival in patients with Sonic hedgehog (SHH) MB. Furthermore, positive correlations between mRNAsi and prognostic copy number aberrations in SHH MB, including MYCN amplifications and GLI2 amplifications, were detected. Analyses of the immune microenvironment revealed unanticipated correlations of MB stemness with infiltrating immune cells. Lastly, using the Connectivity Map, we identified potential drugs targeting the MB stemness signature. Our findings based on stemness indices might advance the development of objective diagnostic tools for quantitating MB stemness and lead to novel biomarkers that predict the survival of patients with MB or the efficacy of strategies targeting MB stem cells.
Passenger muscle responses in lane change and lane change with braking maneuvers using two belt configurations: Standard and reversible pre-pretensioner

Abstract Objective: The introduction of integrated safety technologies in new car models calls for an improved understanding of the human occupant response in precrash situations. The aim of this article is to extensively study occupant muscle activation in vehicle maneuvers potentially occurring in precrash situations with different seat belt configurations. Methods: Front seat male passengers wearing a 3-point seat belt with either standard or pre-pretensioning functionality were exposed to multiple autonomously carried out lane change and lane change with braking maneuvers while traveling at 73 km/h. This article focuses on muscle activation data (surface electromyography [EMG] normalized using maximum voluntary contraction [MVC] data) obtained from 38 muscles in the neck, upper extremities, the torso, and lower extremities. The raw EMG data were filtered, rectified, and smoothed. All muscle activations were presented in corridors of mean ± one standard deviation. Separate Wilcoxon signed ranks tests were performed on volunteers’ muscle activation onset and amplitude considering 2 paired samples with the belt configuration as an independent factor. Results: In normal driving conditions prior to any of the evasive maneuvers, activity levels were low (<2% MVC) in all muscles except for the lumbar extensors (3–5.5% MVC). During the lane change maneuver, selective muscles were activated and these activations restricted the sideway motions due to inertial loading. Averaged muscle activity, predominantly in the neck, lumbar extensor, and abdominal muscles, increased up to 24% MVC soon after the vehicle accelerated in lateral direction for all volunteers. Differences in activation time and amplitude between muscles in the right and left sides of the body were observed relative to the vehicle’s lateral motion. For specific muscles, lane changes with the pre-pretensioner belt were associated with earlier muscle activation onsets and significantly smaller activation amplitudes than for the standard belt (P < .05). Conclusions: Applying a pre-pretensioner belt affected muscle activations; that is, amplitude and onset time. The present muscle activation data complement the results in a preceding publication, the volunteers’ kinematics and the boundary conditions from the same data set. An effect of belt configuration was also seen on previously published volunteers’ kinematics with lower lateral and forward displacements for head and upper torso using the pre-pretensioner belt versus the standard belt. The data provided in this article can be used for validation and further improvement of active human body models with active musculature in both sagittal and lateral loading scenarios intended for simulation of some evasive maneuvers that potentially occur prior to a crash.