Miracle-dz/UniFAR-FTUs huggingface dataset:
Bioavailability of Phytochemical Constituents From a Novel Soy Fortified Lycopene Rich Tomato Juice Developed for Targeted Cancer Prevention Trials

Studies suggest that tomato and soy foods may contribute to a lower risk of certain cancers. We developed a novel soy germ tomato juice to be used in controlled cancer prevention trials. This study describes an initial test of compliance, phytochemical bioavailability, and effects on biomarkers of blood lipids. Healthy men and women (n = 18) consumed a soy germ-fortified juice daily (300 mL supplying 66 mg isoflavones and 22 mg lycopene) for 8 wk. A single-dose bioavailability study was completed on day 1 and isoflavones in plasma and urine, and lycopene in the plasma, were measured. All subjects completed the trial, with 97.7% ± 3.5% (mean ± SD) of the scheduled juice consumed. No adverse effects were documented. The postprandial study indicated that 3.1% ± 2.3% of lycopene was absorbed and that 49.3% ± 12.1% isoflavones ingested were recovered in 24-h urines. Lycopene plasma concentration changed from 0.60 ± 0.22 to 1.24 ± 0.30 μmol/L during 8 wk of consumption. Juice consumption significantly improved resistance of LDL+VLDL-C to Cu2+-mediated oxidation (P = 0.039), HDL-C (47.3 ± 15.8 to 51.7 ± 14.8 mg/dL, P < 0.001), and the ratio of total-C/HDL-C (4.25 ± 1.59 to 3.63 ± 1.16, P < 0.001) at 8 wk. A well-characterized soy-fortified tomato juice can be produced in large scale for multiinstitutional long-term cancer prevention trials and showed excellent compliance with no toxicity, while demonstrating absorption of biologically active phytochemicals.
Observation of extremely large quadratic susceptibility at 9.6-10.8 microm in electric-field-biased AlGaAs quantum wells.

We have observed an extremely large second-order susceptibility for second-harmonic generation of 9.6\char21{}10.8 \ensuremath{\mu}m radiation due to intersubband transitions in electric-field-biased GaAs quantum wells. For 92-A\r{} GaAs wells with 309-A\r{} ${\mathrm{Al}}_{0.48}$${\mathrm{Ga}}_{0.52}$As barriers under a bias of 36 kV/cm, the peak value of the susceptibility was 28 nm/V, 73 times larger than bulk GaAs. The magnitude and sign of the susceptibility depend on the bias field, and are in accord with theoretical predictions.
The East Asian Crisis: Investigating Causes and Policy Responses

Using panel data for Peru for the period 1994-2000, we find that when households receive two or more services jointly, the welfare increases of the household, as measured by changes in consumption, are larger than when services are provided separately. Such an increase appears to be more than proportional, as F-tests on the coefficients of the corresponding regressors confirm. Thus, we find that bundling of services may help realize welfare effects.
Evidence from Japanese Manufacturing Industries

The fraction of exporters and that of multinational enterprises (MNEs) vary substantially across industries. We use firm heterogeneity model presented in Helpman at al. (2004) to derive the testable predictions on the prevalence of these internationalized modes. The model indicates that the intra-industry firm heterogeneity and R&D intensity play the large role in the inter-industry variation of the fraction of internationalized firms. We investigate whether these factors as well as import tariff affect the structure of export and foreign direct investment (FDI), using Japanese industry-level data. We obtain results which are consistent with the model. First, industries with larger productivity dispersion have the larger fraction of non-MNE exporters, the larger fraction of MNEs, the larger relative fraction of MNEs over non-MNE exporters, and the larger fraction of exporters and MNEs. Second, MNEs are heavily concentrated in R&D intensive industries. In addition, we reveal that lower import tariff raises the fraction of exporters and that of MNEs in line with Melitz (2003). The model fits better the data for internationalization to North America and Europe than that for internationalization to Asia. JEL: F1, F23
Mycobacterium avium subsp. paratuberculosis, Genetic Susceptibility to Crohn's Disease, and Sardinians: the Way Ahead

ABSTRACT The present study was performed to determine what proportion of people in Sardinia with or without Crohn's disease were infected with Mycobacterium avium subspecies paratuberculosis and had a preponderance of allelic variants of Nod2, an intracellular protein involved in Crohn's disease susceptibility. Genetic analysis of the alleles of the NOD2/CARD15 gene (insC3020, G908R, and R702W alleles), linked to susceptibility or genetic predisposition to Crohn's disease in humans, was carried out on specimens from 37 Crohn's disease patients and 34 patients without Crohn's disease. Our results show that more than 70 percent of people in Sardinia with Crohn's disease carry at least one of the susceptibility-associated NOD2/CARD15 alleles and were infected with Mycobacterium avium subspecies paratuberculosis.
Currying Favor to Win IPO Mandates

This paper investigates whether a bank can win IPO mandates by issuing flattering analyst recommendations to recent IPOs. We find that security analysts increase their bank's chance of comanaging an IPO when they issue generous recommendations to recent IPOs managed by the IPO's lead manager. However, this result holds only for prestigious banks. Less prestigious banks, whose recommendations are less influential, do not obtain such rewards from lead managers. We also find that security analysts increase their bank's chance of managing future IPOs when they issue generous recommendations to recent IPOs managed by their own bank. This result, however, holds only for non-prestigious banks. These banks, which are not the issuers' first choice, appear to advertize their services by issuing generous analyst coverage to their recent offerings.
Analysts’ Stock Recommendations, Cash Flow Valuations, and Stock Return Profitability

This paper examines whether analysts’ stock recommendations are informed by their cash flow forecasts, and whether these recommendations and cash flow forecasts provide investors with useful information to identify mispriced securities. In doing so, the paper contributes to the ongoing debate regarding the sophistication and value of analysts’ cash flow forecasts. Our findings show that analysts’ stock recommendations are informed by their cash flow forecasts when their forecasts are used in simple cash flow valuation heuristics. However, using these recommendations and heuristics to identify mispricing fails to earn investors excess returns. In contrast, we show that buy-and-hold investors earn significant excess returns by identifying mispricing using analysts’ cash flow forecasts in a discounted valuation model. Overall, we provide the first empirical evidence to suggest that, while analysts apparently fail to use their cash flow forecasts in a sophisticated valuation model, investors can use these forecasts in this manner to identify mispriced securities to earn significant excess returns.
Consumer behavior and the anticipation of a total stockout for a food product: proposing and validating a theoretical model

This paper investigates a new context which has not been studied by previous research, the product total stockout. This research can interest the distributor (or the seller) as well as the manufacturer of products. It helps in avoiding the causes of a total stockout and trying to satisfy consumers by adapting their marketing actions to consumer reactions toward food total stockout. This research proposes and validates a model explaining consumer behavior when anticipating a total stockout for a food product. An exploratory study developed the theoretical model. The quantitative validation of this model is achieved with a sample of 380 consumers, using the Structural Equation Model. Results show that total stockout anticipation is influenced by word-of-mouth and the perceived range assortment of the product. Consumer reactions in the case of a total stockout partially differ from those identified by past research on simple stockouts. For example, product stockpiling and product price acceptance appear as important reactions to a total stockout for a product. However, product substitution intention does not represent a consequence of this anticipation. This research is focused on one product (milk). This affects the possibility of generalizing results for other food product categories. It does not investigate moderating factors, which can be the object of future research.
Hypersensitivity reactions to nonsteroidal anti-inflammatory drugs: from phenotyping to genotyping

Purpose of reviewNonsteroidal anti-inflammatory drugs (NSAIDs) are the most frequent drugs involved in hypersensitivity drugs reactions. Both immunological and nonimmunological mechanisms can be involved. We describe the different phenotypes as well as analyze the genetic basis for NSAIDs hypersensitivity. Recent findingsFive major clinical entities are currently accepted in the classification of hypersensitivity reactions to NSAIDs. Three are mediated by nonspecific immunological mechanisms: NSAIDs-exacerbated respiratory disease, NSAIDs-exacerbated cutaneous disease and NSAIDs-induced urticaria/angioedema. Two are mediated by specific immunological mechanisms: single-NSAID-induced urticaria/angioedema or anaphylaxis and single-NSAID-induced delayed hypersensitivity reactions. The classification becomes more complex if we consider that in an important number of cases skin and airway involvement can occur, as well as the participation of other organs. SummaryHypersensitivity reactions to NSAIDs are more complex than for other drugs like betalactams in terms of the number and types of reactions elicited, and mechanisms involved. As NSAIDs are the most frequent cause of drug hypersensitivity, it is feasible to gather a sufficient number of cases for undertaking pharmacogenetic studies.
3-(4-Amino-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)pyridinium chloride

In the title compound, C7H8N5S+·Cl−, the dihedral angle formed by the pyridine ring with the triazole ring is 10.0 (1)°. There are weak intermolecular hydrogen-bond interactions in the crystal structure, involving the NH and NH2 groups as donors, and the chloride anion, the S atom in the thioketone group and the unsubstituted ring N atom as acceptors.
Abstract 466: Redox Regulation of 14-3-3zeta Controls Monocyte Migration

Cofilin regulates actin turnover and is inactivated by phosphorylation at Ser-3 by LIM kinase (LIMK) and reactivated by the cofilin-phosphatase Slingshot-1L (SSH1L). We recently reported that protein-S-glutathionylation induced by metabolic disorders enhances monocyte recruitment into vascular lesions. Because monocyte priming and accelerated migration involves increases actin turnover, we tested the hypothesis that these regulators of actin assembly/disassembly are redox-regulated. Metabolic priming was induced in human THP-1 monocytes by exposing the cells to diabetic conditions, i.e. human native LDL plus high glucose concentrations (LDL+HG). Phosphorylation of cofilin in response to MCP-1 was completely blocked in metabolically primed monocytes, suggesting that hyperactivation of cofilin may contribute to the enhanced chemotactic activity of primed monocytes. Yet, neither LIMK1 nor SSH1L levels were affected by metabolic stress. However, metabolic priming resulted in a 3.8-fold increase the S-glutathionylation of 14-3-3zeta, a SSH1L binding protein which maintains the cofilin phosphatase in an inactive state. S-glutathionylation of 14-3-3zeta resulted in its caspase-dependent degradation and a 35% reduction in 14-3-3zeta protein levels. Overexpression of glutaredoxin 1 in monocytes inhibited both LDL+HG-induced S-glutathionylation and degradation of 14-3-3zeta, and normalized cofilin phosphorylation in response to MCP-1. The C25S mutant of 14-3-3zeta was resistant to S-glutathionylation and degradation induced by LDL+HG, and restored MCP-1-induced cofilin phosphorylation in metabolically primed monocytes. 14-3-3zeta S-glutathionylation did not affect binding of 14-3-3zeta to SSH1L, suggesting that loss of 14-3-3zeta increases the pool of free SSH1L phosphatase, thus preventing the phosphorylation and deactivation of cofilin in response to chemokine activation. In conclusion, we identified a novel redox-sensitive mechanism for the regulation of monocyte migration that links (thiol) oxidative stress induced by metabolic disorders to monocyte dysfunction and the conversion of blood monocytes into a hypermigratory, proinflammatory and proatherogenic phenotype.
Attitudes Towards Product Website Design: A Study of the Effects of Gender

The research of the Internet2 project has resulted in the introduction of new technologies and has set the stage for another round of Internet growth. These technologies will enhance interactivity and allow for the delivery of greater amounts of information through richer communication. With these new options, World Wide Web‐based retailers must now rethink the design of their sites, the amount of information to deliver and the degree of media richness to provide. This article sets forth an overview of the evolution of the Internet, presents relevant media richness theory, gives a review of the literature with regard to gender and the Internet and presents an empirical illustration of the effects of gender on attitudes towards website design. The results suggest that, overall, males have more positive attitudes than females with regard to both rich and lean websites. The study details the development of an experimental instrument for measuring user attitudes and discusses the impact of the results.
Investigating the central executive in adult dyslexics: Evidence from phonological and visuospatial working memory performance

There is long-standing evidence for verbal working memory impairments in both children and adults with dyslexia. By contrast, spatial memory appears largely to be unimpaired. In an attempt to distinguish between phonological and central executive accounts of the impairments in working memory, a set of phonological and spatial working memory tasks was designed to investigate the key issues in working memory, task type, task demands (static, dynamic, and updating), and task complexity. Significant differences emerged between the dyslexic and nondyslexic participants on the verbal working memory tasks employed in Experiment 1, thereby providing further evidence for continuing dyslexic impairments of working memory into adulthood. The nature of the deficits suggested a problem with the phonological loop, with there being little evidence to implicate an impairment of the central executive. Due to the difficulties associated with separating verbal working memory and phonological processing, however, performance was investigated in Experiment 2 using visuospatial measures of working memory. The results of the visuospatial tasks indicated no between-group differences in static spatial memory, which requires the short-term storage of simultaneously presented information. In almost all conditions there were no between-group differences in dynamic spatial memory that demands the recall of both location and order of stimuli presented sequentially. However, a significant impairment occurred on the dynamic task under high memory updating load, on which dyslexic adults showed nonphonological working memory deficits. In the absence of an explanation involving verbal recoding, this finding is interpreted in terms of a central executive or automaticity impairment in dyslexia.
THE MODE OF ACTION OF CHLORINATED BISPHENOL ANTIBACTERIALS: Part I. Metal Chelates of Hexachlorophene and Thiobisdichlorphenol

2:2′‐Thiobis(4:6‐dichlorphenol) has been found to chelate with Fe++, Fe+++, Cu++, Mn++ and Co++ as shown by colorimetric, Potentiometrie and analytical data. Crystalline copper, iron and cobalt chelates of thiobisdichlorphenol have been isolated and their structures determined. Hexachlorophene chelates with Fe++, Fe+++ and Cu++ as demonstrated by Potentiometrie titrations in the presence and absence of metals. But stable crystalline chelates could not be isolated. The suggestion is made that the structure activity relationship in the bisphenol group of antibacterials is connected with the ability of the molecule to chelate with certain metals.
Preparation and characterization of iron-containing liposomes: their effect on soluble iron uptake by Caco-2 cells

The aim of this work was to study the iron uptake of Caco-2 cells incubated with five different formulations of liposomes containing iron. The vesicles were also characterized before, during, and after in vitro digestion. Caco-2 cells were incubated with digested and nondigested liposomes, and soluble iron uptake was determined. Nondigested liposomes made with chitosan (CHI) or the cationic lipid, DC-Cholesterol (DC-CHOL), generated the highest iron uptake. However, these two formulations were highly unstable under in vitro digestion, resulting in nonmeasurable iron uptake. Digested conventional liposomes composed of soybean phosphatidylcholine (SPC), hydrogentated phosphatidylcholine (HSPC), or HSPC and cholesterol (CHOL) presented the highest iron-uptake values. These liposomal formulations protected iron from oxidation and improved iron uptake from intestinal cells, compared to an aqueous solution of ferrous sulphate.
Reply to letters from Fall and Bailey, and Muldoon.

Two letters were recently submitted to the editor regarding our recent publication (1), both of which raised important issues. Fall and Bailey identified discrepancies between their previous work (2) and ours, which deserve consideration. They also used the same correction technique of Dill and Costill (3) after maximal 223 Konstanzer Online-Publikations-System (KOPS)
Antibody‐dependent cellular cytotoxicity of cetuximab against tumor cells with wild‐type or mutant epidermal growth factor receptor

Cetuximab (Erbitux, IMC‐C225) is a monoclonal antibody targeted to the epidermal growth factor receptor (EGFR). To clarify the mode of antitumor action of cetuximab, we examined antibody‐dependent cellular cytotoxicity (ADCC) activity against several tumor cell lines expressing wild‐type or mutant EGFR. ADCC activity and complement‐dependent cytolysis activity were analyzed using the CytoTox 96 assay. ADCC activities correlated with the EGFR expression value (R = 0.924). ADCC activities were detected against all tumor cell lines, except K562 cells in a manner dependent on the cellular EGFR expression level, whereas complement‐dependent cytolysis activity was not detected in any of the cell lines. The ADCC activity mediated by cetuximab was examined in HEK293 cells transfected with wild‐type EGFR (293W) and a deletional mutant of EGFR (293D) in comparison with the mock transfectant (293M). ADCC activity was detected in 293W and 293D cells, in a cetuximab dose‐dependent manner, but not in 293M cells (<10%). These results indicate that ADCC‐dependent antitumor activity results from the degree of affinity of cetuximab for the extracellular domain of EGFR, independent of EGFR mutation status. These results suggest ADCC activity to be one of the modes of therapeutic action of cetuximab and to depend on EGFR expression on the tumor cell surface. (Cancer Sci 2007; 98: 1275–1280)
ANTECEDENTS AND DIMENSIONS OF CUSTOMER PARTNERING BEHAVIOR IN LOGISTICS OUTSOURCING RELATIONSHIPS

In order to be successful in today's competitive environment, third-party logistics providers (3PLs) increasingly strive to develop close, mutually beneficial long-term relationships with customers. The current study identifies inter-organizational conditions and firm-specific factors that influence a firm's partnering behavior with its 3PL. A model of the antecedents and dimensions of partnering behavior is developed and tested with a diverse set of relationships between a focal 3PL and members of its customer base.
Comparative Advertising: The Influence of Attitude-toward-the-Ad on Brand Evaluation

Abstract Although it has been documented that attitudes toward ads (AAd) often have a direct influence on brand attitudes, no such investigation has been undertaken in the context of comparative advertising, where multiple brands are referenced and displayed. In such situations, it is unclear whether the competitive (referred-to) brand may also be affected by AAd. Results of an empirical study indicate that the transfer of affect from ads to brands occurs almost exclusively for the sponsoring brand. AAd has no measurable effect on attitudes toward the competitive brand.
Altered Expression of Nuclear Non-Histone Protein (P44/46) in Different Stages of B-Chronic Lymphocytic Leukemia

Our previous data have shown some differences in electrophoretic characteristics of proteins from cellular fractions (nuclear, mitochondrial, microsomal and cytosolic) isolated from peripheral blood mononuclear cells of B-cell chronic lymphocytic leukemia (B-CLL), acute lymphoblastic leukemia (ALL) patients and healthy donors. The main differences were found in electrophoretic patterns of nuclear proteins from normal and leukemia cells, especially in the nuclear mass regions of 36–52, 58–85, and 120–180 kDa. Electrophoretically-specific nuclear non-histone protein in the molecular mass zone 44/46 kDa of cells obtained from the peripheral blood of a B-CLL patient was used to produce rabbit polyclonal antiserum. SDS-polyacrylamide gel electrophoresis as well as immunological techniques (Western blot and immunocytochemistry) indicate that the nuclear protein with a molecular mass of 44/46 kDa is specifically expressed in mononuclear cells from B-CLL patients. The expression of this particular nuclear protein seems to correlate with the progression of the leukemia.
The prevalence of psychiatric morbidity and its associated factors in general health care in Taiwan

Background. This paper reports the prevalence, disability, sociodemographic and clinical association of psychiatric morbidity among attenders in general health care in Taiwan where, as in the rest of non-Western countries, few studies have been carried out. Methods. A cross-sectional survey with a two-phase design was carried out at out-patient clinics of three health stations and a general hospital. Results. A total of 990 patients completed the brief screen in the first phase, 486 of whom completed the independent assessment in the second phase. The proportion of screening positives was 46·0% and the weighted prevalence of definite psychiatric disorder was 38·2%. Common mental disorders were associated with female gender and unemployment. Housewives, students and patients with higher educational attainment were at lower risk of having alcohol use disorders. Patients with common mental disorders were more likely to present with psychological complaints, to attribute their illness to psychosocial causes and to perceive their mental and physical health as poor. Psychiatric morbidity was associated with excess life events. Common mental disorders, particularly depressive disorders, were significantly associated with self-reported disability. Conclusions. Psychiatric morbidity is a major health problem in general health care in Taiwan. Physicians should be aware of these health problems.
'Models and Methods for Evaluation of Hybrid Corporate Bonds - A Critical Overview'

Hybrid corporate bonds are innovative financial instruments which are classified as a mixed (i.e., a "hybrid") form of financing which by definition combine characteristics of equity and debt i.e. they have both equity-like and debt-like issue features. The discussion on hybrid bonds has traditionally focused mainly on functional and regulatory aspects, while evaluation issues have rarely been explored. The intention of this paper is therefore to provide an overview of models and approaches for the evaluation of these complex financial vehicles. Besides sophistic theoretical models, the focus is also on pragmatic methods that approach the virulent evaluation problem from a more practical point of view.