Miracle-dz/UniFAR-FTUs huggingface dataset:
The Impact of a Workplace-Based Weight Loss Program on Work-Related Outcomes in Overweight Male Shift Workers

Objective: The aim of this study was to evaluate the impact of a workplace-based weight loss program (Workplace POWER [Preventing Obesity Without Eating like a Rabbit]) for male shift workers on a number of work-related outcomes. Methods: A total of 110 overweight/obese (body mass index = 25–40) (mean [SD] age = 44.3 [8.6] years; body mass index = 30.5 [3.6]) male employees at Tomago Aluminium (New South Wales, Australia) were randomized to either (i) Workplace POWER program (n = 65) or (ii) a 14-week wait-list control group (n = 45). Men were assessed at baseline and 14-week follow-up for weight, quality of life, sleepiness, productivity at work (presenteeism), absenteeism, and workplace injuries. Results: Retention was 81%. Intention-to-treat analysis using linear mixed models revealed a significant intervention effect for weight, quality of life (mental), presenteeism, absenteeism, and injuries. Conclusions: The Workplace POWER weight loss program improved a number of important work-related outcomes in male shift workers.
Characterization and Computation of Optimal Policies for Operating an M/G/1 Queuing System with Removable Server

This paper studies the optimal operation of an M/G/1 queuing system with removable server and the following cost structure: a holding cost per customer in the system per unit time, a cost per unit time of keeping the server running, and fixed charges for turning the server on or off. The server can be turned on at arrival epochs or off at service-completion epochs. The paper characterizes an optimal policy for the infinite-horizon discounted problem, offers an optimality proof, and presents a computational algorithm.
Barrier diameter effect on the behaviour of transformer oil submitted to AC voltage

Dielectric interfaces can have a significant effect on the insulating performances of HV apparatus. The oil/solid interface represents a relatively weak component of an insulation system in power transformer. Therefore, when we are considering the effect of oil breakdown in oil filled transformer, we should consider the interactions which electrical discharges may have with solid surfaces. This work is devoted to the influence of insulating barrier on the behaviour of transformer oil under ac voltage in point-plane electrode configuration. The influence of the characteristics of barrier such as its position between electrodes, and its diameter on the pre-breakdown and breakdown phenomena is investigated. It is shown that the insertion of barrier near the point electrode increases the breakdown voltage and leads to decrease the pre-breakdown charge. The increase of breakdown voltage is due to the channel elongation of the disruptive charge. By determination of the pre-breakdown charge and breakdown voltage, we can estimate the optimal position of the barrier. The barrier diameter influences the breakdown voltage, the pre-breakdown charge and the trajectory of discharge.
Actin‐binding proteins in a postsynaptic preparation: Lasp‐1 is a component of central nervous system synapses and dendritic spines

CNS synapses are complex sites of cell–cell communication. Identification and characterization of the protein components of synapses will lead to a better understanding of the mechanisms of neurotransmission and plasticity. We applied multidimensional protein identification technology (MudPIT) to purified, guanidine‐solubilized postsynaptic fractions to identify novel synaptically localized molecules. We identified several actin‐associated proteins known to regulate actin polymerization and control cell motility in nonneural cells that have not previously been associated with CNS synaptic function. One of these is lasp‐1, an actin‐associated LIM and SH3 domain‐containing protein. We show that lasp‐1 is strongly expressed by CNS neurons and is concentrated at synaptic sites. Overall, the preponderance of actin‐associated proteins in postsynaptic density fractions, and specifically those involved in actin reorganization, suggests that there are many modes by which the state of synaptic F‐actin polymerization and, hence, synaptic physiology are affected. © 2004 Wiley‐Liss, Inc.
Short-Term Caloric Restriction Induces Accumulation of Myocardial Triglycerides and Decreases Left Ventricular Diastolic Function in Healthy Subjects

OBJECTIVE—Diabetes and obesity are associated with increased plasma nonesterified fatty acid (NEFA) levels, myocardial triglyceride accumulation, and myocardial dysfunction. Because a very low–calorie diet (VLCD) also increases plasma NEFA levels, we studied the effect of a VLCD on myocardial triglyceride content and cardiac function in healthy subjects. RESEARCH DESIGN AND METHODS—Fourteen healthy nonobese men underwent 1H-magnetic resonance spectroscopy (MRS) to determine myocardial and hepatic triglyceride content, 31P-MRS to assess myocardial high-energy phosphate (HEP) metabolism (phosphocreatine/ATP), and magnetic resonance imaging of myocardial function at baseline and after a 3-day VLCD. RESULTS—After the dietary intervention, plasma NEFA levels increased compared with those at baseline (from 0.5 ± 0.1 to 1.1 ± 0.1 mmol/l, P < 0.05). Concomitantly, myocardial triglyceride content increased by ∼55% compared with that at baseline (from 0.38 ± 0.05 to 0.59 ± 0.06%, P < 0.05), whereas liver triglyceride content decreased by ∼32% (from 2.2 ± 0.5 to 1.5 ± 0.4%, P < 0.05). The VLCD did not change myocardial phosphocreatine-to-ATP ratio (2.33 ± 0.15 vs. 2.33 ± 0.08, P > 0.05) or systolic function. Interestingly, deceleration of the early diastolic flow across the mitral valve decreased after the VLCD (from 3.37 ± 0.20 to 2.91 ± 0.16 ml/s2 × 10−3, P < 0.05). This decrease in diastolic function was significantly correlated with the increase in myocardial triglyceride content. CONCLUSIONS—Short-term VLCD induces accumulation of myocardial triglycerides. In addition, VLCD decreases left ventricular diastolic function, without alterations in myocardial HEP metabolism. This study documents diet-dependent physiological variations in myocardial triglyceride content and diastolic function in healthy subjects.
The use of free online educational resources by Canadian emergency medicine residents and program directors.

UNLABELLED Introduction Online educational resources (OERs) are increasingly available for emergency medicine (EM) education. This study describes and compares the use of free OERs by the Royal College of Physicians and Surgeons of Canada (RCPSC) EM residents and program directors (PDs) and investigates the relationship between the use of OERs and peer-reviewed literature. METHODS A bilingual, online survey was distributed to RCPSC-EM residents and PDs using a modified Dillman method. The chi-square test and Fisher's exact test were used to compare the responses of residents and PDs. RESULTS The survey was completed by 214/350 (61%) residents and 11/14 (79%) PDs. Free OERs were used by residents most frequently for general EM education (99.5%), procedural skills training (96%), and learning to interpret diagnostic tests (92%). OER modalities used most frequently included wikis (95%), file-sharing websites (95%), e-textbooks (94%), and podcasts (91%). Residents used wikis, podcasts, vodcasts, and file-sharing websites significantly more frequently than PDs. Relative to PDs, residents found entertainment value to be more important for choosing OERs (p<0.01). Some residents (23%) did not feel that literature references were important, whereas all PDs did. Both groups reported that OERs increased the amount of peer-reviewed literature (75% and 60%, respectively) that they read. CONCLUSIONS EM residents make extensive use of OERs and differ from their PDs in the importance that they place on their entertainment value and incorporation of peer-reviewed references. OERs may increase the use of peer-reviewed literature in both groups. Given the prevalence of OER use for core educational goals among RCPSC-EM trainees, future efforts to facilitate critical appraisal and appropriate resource selection are warranted.
Vascular Density of the Posterior Tibial Tendon: A Cadaver Study

Background: Degenerative pathology of the posterior tibial tendon, a common cause of foot and ankle dysfunction, frequently affects women over 40 years of age. Its etiology is still controversial. The literature reports decreased vascularization coinciding with the most common site of the lesion, near the medial malleolus. Methods: Forty pairs of PTT obtained from human cadavers were transversally cut into six levels, from the musculotendon transition to its insertion point. In each segment, a histologic cut was made and stained with Masson's trichrome allowing viewing of the vascular structure of the tendon under a light microscope. By using an integrating eyepiece on the microscope, vascular density was calculated. This verified any variation of the vascular concentration in the normal tendon, a possible cause of its degeneration. Results: When the results were compared by side, sex, and age, no statistically significant difference was observed. When the levels were compared, no area of decreased vascularization was seen in the midportion of the tendons, the most common site of degeneration of the posterior tibial tendon. Conclusion: These results indicate that an area of decreased vascularity is not a factor in degeneration of the posterior tibial tendon at the medial malleolus.
Analysis of the methylation sites in yeast ribosomal RNA.

The methylation sites and the number of methyl groups of 26-S and 17-S ribosomal RNA (rRNA) of Saccharomyces carlsbergensis were investigated. 28-S and 17-S rRNA contain 43 and 24 methyl groups per molecule, respectively, of which in both molecules 6 are attached to the heterocyclic bases. In 26-S rRNA the base-methyl groups are present as two copies of m3U, m5C as well as m1A, whereas the methylated bases in 17-S rRNA are one m7G, one methylated cytidine and two of m26A. In 17-S rRNA there are 11 different alkali-stable (i.e. ribose-methylated) dinucleotides, while 26-S rRNA contains 15 different alkali-stable dinucleotides, and in addition 4 alkali-stable trinucleotides (Am-Cm-Gp, Am-Gm-Cp, Am-Am-Up and Um-Gm-Ψp). Most of the methylated oligonucleotides found in a ribonuclease T1 digest of 26-S or 17-S rRNA occur in approximately one-molar amounts. The combined data suggest that yeast ribosomal RNA is essentially homogeneous in its methylated sequences and in addition that the methylation is a highly specific process.
Emotional Distress in Partners of Patients with an Implantable Cardioverter Defibrillator: A Systematic Review and Recommendations for Future Research

Both patients with an implantable cardioverter defibrillator (ICD) and their partners face challenges when adapting to the ICD. Distress is a burden on its own for partners but may also affect well being and health of patients. This review provides a systematic overview of the literature on psychological distress in partners of ICD patients and recommendations for future research.
Dynamics of HIV viremia and antibody seroconversion in plasma donors: implications for diagnosis and staging of primary HIV infection

Objectives: The characterization of primary HIV infection by the analysis of serial plasma samples from newly infected persons using multiple standard viral assays. Design: A retrospective study involving two sets of archived samples from HIV-infected plasma donors. (A) 435 samples from 51 donors detected by anti-HIV enzyme immunoassays donated during 1984–1994; (B) 145 specimens from 44 donors detected by p24 antigen screening donated during 1996–1998. Setting: Two US plasma products companies. Main outcome measures: The timepoints of appearance of HIV-1 markers and viral load concentrations during primary HIV infection. Results: The pattern of sequential emergence of viral markers in the ‘A’ panels was highly consistent, allowing the definition and estimation of the duration of six sequential stages. From the ‘B’ panels, the viral load at p24 antigen seroconversion was estimated by regression analysis at 10 000 copies/ml (95% CI 2000–93 000) and the HIV replication rate at 0.35 log copies/ml/day, corresponding to a doubling time in the preseroconversion phase of 20.5 h (95% CI 18.2–23.4 h). Consequently, an RNA test with 50 copies/ml sensitivity would detect HIV infection approximately 7 days before a p24 antigen test, and 12 days before a sensitive anti-HIV test. Conclusion: The sequential emergence of assay reactivity allows the classification of primary HIV-1 infection into distinct laboratory stages, which may facilitate the diagnosis of recent infection and stratification of patients enrolled in clinical trials. Quantitative analysis of preseroconversion replication rates of HIV is useful for projecting the yield and predictive value of assays targeting primary HIV infection.
The Ameba Balamuthia mandrillaris Feeds by Entering into Mammalian Cells in Culture

ABSTRACT. Microscopic observations of live cultures of the pathogenic ameba Balamuthia mandrillaris and mammalian cells showed that amebic feeding involved the invasion of the pseudopodia, and/or the whole ameba into the cells. The ameba, recognized by their size and flow of organelles in the cytosol, was seen to extend the tip of a pseudopodium into the cytoplasm of a cell where it moved about leaving visible damage when retracted. In rounded cells, whole amebas were seen to enter into and move around before exiting a cell and then remain quiescent for hours. The invaded mammalian cells retained their turgidity and excluded vital dyes until only their denuded nuclei remained. The cytoplasm of the cells was consumed first, then the nuclei, but not their mitotic chromosomes. The feeding pattern of four isolates of B. mandrillaris, two from humans and two from soil samples, was by amebic invasion into the mammalian cells. The resulting ameba population included cysts, amebas on the surface, and free‐floating amebas as individuals or in dense‐packed clusters. There was no morphologic indication of a cytopathic change in the mammalian cells before their invasion by the amebas. Feeding by cell invasion is a distinctive feature of B. mandrillaris.
B cells are not required for T cell priming in low zone tolerance to contact allergens and contact hypersensitivity

Low zone tolerance (LZT) to contact allergens is induced by epicutaneous exposure to haptens in subsensitizing doses resulting in an inhibition of contact hypersensitivity (CHS), which, in contrast, occurs after sensitization with immunogenic doses of allergens. Performing the protocol of tolerance induction resulted in robust LZT to allergens in B cell‐deficient mice in vivo, indicating that B cells are not required for the induction and effector phase of LZT. However, CHS reactions in vivo were restricted in B cell‐deficient mice as compared to wild‐type (WT) mice. In contrast, analysis of hapten‐specific T cell activation in vitro revealed a strong proliferative response of T cells derived from both WT and B cell‐deficient sensitized mice. Similar to WT animals, T cells obtained from tolerized B cell‐deficient mice produced a Tc2 cytokine pattern of LZT with high levels of IL‐4 and IL‐10, whereas sensitization of B cell‐deficient mice resulted in the typical Tc1 cytokine profile of CHS. Adoptive transfer of CD8+ effector T cells from tolerized or sensitized B cell‐deficient mice induced significant LZT or CHS reactions, respectively, in WT recipients, demonstrating that the development of hapten‐specific effector CD8+ T cells of LZT and CHS is independent of B cells.
Nonaqueous liquid electrolytes for lithium-based rechargeable batteries.

2.1. Solvents 4307 2.1. 1. Propylene Carbonate (PC) 4308 2.1. 2. Ethers 4308 2.1. 3. Ethylene Carbonate (EC) 4309 2.1. 4. Linear Dialkyl Carbonates 4310 2.2. Lithium Salts 4310 2.2.1. Lithium Perchlorate (LiClO4) 4311 2.2.2. Lithium Hexafluoroarsenate (LiAsF6) 4312 2.2. 3. Lithium Tetrafluoroborate (LiBF4) 4312 2.2. 4. Lithium Trifluoromethanesulfonate (LiTf) 4312 2.2. 5. Lithium Bis(trifluoromethanesulfonyl)imide (LiIm) and Its Derivatives 4313
[Etiological surveillance and analysis of infectious diarrhea in Beijing in year 2010].

OBJECTIVE To explore the pathogenic form, epidemic features and serotype distribution of the pathogenic bacteria causing infectious diarrhea in Beijing. METHODS A total of 2118 samples of rectal swabs and stool specimens of diarrheal patients were collected from 6 surveillant intestinal tract clinics during the period between April and October, 2010. Enteric multiple pathogens including Vibrio cholerae, Vibrio parahaemolyticus, Salmonella, Shigella and diarrheagenic Escherichia coli were detected by the isolation culture, biochemical identification and serotyping methods. The population distribution, temporal distribution and serotype distribution of the above pathogenic bacteria were analyzed by descriptive statistical methods. RESULTS 478 strains isolated from the total 2118 specimens were positive for pathogen detection, accounting to 22.6%. Among the 478 strains of pathogenic bacteria, Shigella accounting for 40.8% (195/478) was the most frequent pathogen, followed by Vibrio parahaemolyticus accouting for 23.8% (114/478), Salmonella accounting for 19.0% (91/478) and diarrheagenic Escherichia coli accounting for 4.8% (23/478). Enteric pathogenic bacteria spread mainly among adults aging between 20 and 39; and the distribution was different among different age groups, while the highest detected rate was in 30 - 39 age group, accounting for 27.2% (92/338). The detected rate of pathogenic bacteria showed evident seasonal variations, with a peak from July to October, whose detected rates were 23.5% (114/486), 32.8% (176/536), 36.1% (90/249) and 25.9% (29/112) respectively. The detected rates in other months were all under 16.0%. Shigella Sonnei was the dominant serotype, accounting for 83.1% (162/195). O3:K6 was the dominant serotype among Vibrio parahaemolyticus, accounting for 63.2% (72/114). Salmonella Enteritidis and Salmonella Typhimurium were dominant serotypes among Salmonella, accounting for 13.2% (12/91) and 12.1% (11/91) separately. Enterpathogenic Escherichia coli and enterotoxigenic Escherichia coli were the dominant serotypes among Diarrheagenic Escherichia coli, accounting for 69.6% (16/23) and 30.4% (7/23) respectively. CONCLUSION The three main pathogenic bacteria causing infectious diarrhea in Beijing are Shigella, Vibrio parahaemolyticus, Salmonella; and there are obvious changes in the serotype distribution of Shigella and Samonella compared to previous years.
The value of HLA phenotypes in the prognosis of Hodgkin's lymphoma

The study included 52 patients with Hodgkin's disease, 32 males and 20 females, whose ages ranged from 3 to 36 years (34 under and 18 over 15 years). All patients were carefully staged, and lymph‐node biopsies were taken for histopathological examination. HLA phenotype determinations were carried out, and the frequencies were statistically compared with those of normal Egyptian controls. We followed the patients for 3 years to monitor the effect of therapy. In order to determine the prognostic value of patients′ characteristics (age, stage, histologic pattern and HLA phenotypes), statistical analysis and retrospective stratification studies were performed. The frequency of HLA‐AI was significantly increased in our patients. The relative risk showed that persons carrying the Al antigen are 6 times more susceptible than those lacking it. There was no significant difference in the frequency of Al antigen in relation to the histopathologic subtypes. Furthermore, the results revealed a prognostic value of the HLA marker. In conclusion, we suggest that chemotherapy should be added to radiotherapy of marker‐positive patients at any stage.
The Industry 4.0 Journey: Start the Learning Journey with the Reference Architecture Model Industry 4.0

The wave of the fourth industrial revolution (Industry 4.0) is breaking on manufacturing companies. In manufacturing, one of the buzzwords of the moment is "Smart production". Smart production involves manufacturing equipment with many sensors that can generate and transmit large amounts of data. Data and information from manufacturing operations are however not used by most manufacturing companies and this impedes organizational learning. To address this problem, the authors applied in a Smart Production Laboratory the International Electrotechnical Commission (IEC) Reference Architecture Model Industry 4.0 (RAMI4.0) standard for Smart production. The instantiation contributed to organizational learning in the laboratory by collecting and sharing up-to-date information concerning manufacturing
Malware Avoidance Motivations and Behaviors: A Technology Threat Avoidance Replication

The current study presents a conceptual replication of Liang and Xue’s (2010) test of their proposed Technology Threat Avoidance Theory (TTAT). Whereas the original study investigated individuals’ spyware related threat perceptions, avoidance motivations, and behaviors; we applied the original study’s research questions, hypotheses, and model to the more general context of malware. Results from a sample of 486 computer users revealed that safeguard effectiveness, safeguard cost, and self-efficacy are relatively robust predictors of avoidance motivation across varied settings. Perceived severity is a strong predictor of perceived threat, however the impact of this overall threat perception (along with its perceived susceptibility antecedent) may be less stable in predicting avoidance motivation under changing contextual/environmental circumstances. The results suggest that TTAT is a valid foundational framework for examining user behavior related to malicious software. Future research should investigate additional predictors of avoidance motivation such as risk propensity, distrust, and impulse control to improve the power of the model. Additionally, the current TTAT instrument offers several opportunities for enhanced measurement accuracy through item modifications, scale anchor revisions, and improvements in parsimony.
A Fully-Asynchronous Low-Power Implantable Seizure Detector for Self-Triggering Treatment

In this paper, we present a new asynchronous seizure detector that is part of an implantable integrated device intended to identify electrographic seizure onset and trigger a focal treatment to block the seizure progression. The proposed system has a low-power front-end bioamplifier and a seizure detector with intelligent mechanism to reduce power dissipation. This system eliminates the unnecessary clock gating during normal neural activity monitoring mode and reduces power dissipation in the seizure detector; as a result, this device is suitable for long-term implantable applications. The proposed system includes analog and digital building blocks with programmable parameters for extracting electrographic seizure onset information from real-time EEG recordings. Sensitivity of the detector is enhanced by optimizing the variable parameters based on specific electrographic seizure onset activities of each patient. The detection algorithm was validated using Matlab tools and implemented in standard 0.13 μm CMOS process with total die area of 1.5×1.5 mm2. The fabricated chip is validated offline using intracranial EEG recordings from two patients with refractory epilepsy. Total power consumption of the chip is 9 μW and average detection delay is 13.7 s after seizure onset, well before the onset of clinical manifestation. The proposed system achieves an accurate detection performance with 100% sensitivity and no false alarms during the analyses of 15 seizures and 19 non-seizure datasets.