Miracle-dz/UniFAR-FTUs huggingface dataset:
PERAN STRES KERJA DAN KEPUASAN KERJA KARYAWAN DALAM PENGELOLAAN TINGKAT TURNOVER INTENTION PADA KARYAWAN PUSKESMAS JASINGA, BOGOR

Employees who worked in health service experienced various pressures when doing their job. This is because they have to deal with various problems (diseases and treatments). Such condition could affect and even reduce their job satisfaction and in the end also affect their intention to quit. This study analyzed the effect of stress and job satisfaction on employee turnover rate at Puskesmas Jasinga, Bogor. The number of participants in this study was 108 employees. Explanatory methods and mediation analysis are used to explain the relationship and influence between variables. The results showed that employeeâ€™s stress level did not have significant influence on job satisfaction, but stress significantly affected employees' intention to quit. Furthermore, no significant effect of job satisfaction on the desire to resign to employees. The differences in the results of this study with previous studies will be discussed more in depth. Keywords—Works Stress; Job Satisfaction; Turnover Intention. Abstrak Karyawan di bidang kesehatan khususnya puskesmas mengalami berbagai tekanan dalam menjalankan pekerjaannya. Hal ini dikarenakan masalah (penyakit dan perawatan) yang dihadapi relatif beragam. Kondisi tersebut diduga dapat mengurangi kepuasan kerja dan pada akhirnya bisa berakibat pada meningkatnya niat untuk mengundurkan diri. Penelitian ini menganalisis pengaruh stres dan kepuasan kerja terhadap tingkat turnover karyawan di Puskesmas Jasinga, Bogor. Jumlah responden yang berpartisipasi dalam penelitian ini adalah 108 orang. Metode eksplanatori dan analisis mediasi digunakan untuk menjelaskan hubungan dan pengaruh antar variabel. Hasil penelitian memperlihatkan bahwa tingkat stres karyawan tidak memiliki pengaruh signifikan terhadap kepuasan kerja, akan tetapi stres secara signifikan positif mempengaruhi niat karyawan untuk mengundurkan diri. Selanjutnya, tidak ditemukan pengaruh signifikan dari kepuasan kerja terhadap keinginan untuk mengundurkan diri pada karyawan. Kata kunci—Stres Kerja; Kepuasan Kerja; Turnover Intention.
AutoSweep: Recovering 3D Editable Objects from a Single Photograph

This paper presents a fully automatic framework for extracting editable 3D objects directly from a single photograph. Unlike previous methods which recover either depth maps, point clouds, or mesh surfaces, we aim to recover 3D objects with semantic parts and can be directly edited. We base our work on the assumption that most human-made objects are constituted by parts and these parts can be well represented by generalized primitives. Our work makes an attempt towards recovering two types of primitive-shaped objects, namely, generalized cuboids and generalized cylinders. To this end, we build a novel instance-aware segmentation network for accurate part separation. Our GeoNet outputs a set of smooth part-level masks labeled as profiles and bodies. Then in a key stage, we simultaneously identify profile-body relations and recover 3D parts by sweeping the recognized profile along their body contour and jointly optimize the geometry to align with the recovered masks. Qualitative and quantitative experiments show that our algorithm can recover high quality 3D models and outperforms existing methods in both instance segmentation and 3D reconstruction.
Treatment of Osteoporosis: Unmet Needs and Emerging Solutions

Efficient therapies are available for the treatment of osteoporosis, however, there are still unmet needs. Anti-resorptive therapies only increase bone mineral density to a certain extent and reduce the risk of non-vertebral fractures by 20%, only one anabolic option is available in most parts of the world-the effect of which levels off over time, and the evidence for combination therapy targeting both resorption and formation is limited. In addition, identification and treatment of patients with high and imminent fracture risk following a recent fracture and long-term adherence to treatment are 2 other very prominent challenges to the management of osteoporosis. The current review will focus on emerging osteoporosis treatments and optimized use of the existing treatments that may help overcome the currently unmet needs in the management of osteoporosis.
Jamaican Mothers’ Perceptions of Children’s Strategies for Resisting Parental Rules and Requests

Research on Jamaican socialization of children has primarily focused on parental discipline practices. Little is known about children’s responses to parental attempts to control their behavior. The present study investigated mothers’ perceptions of children’s strategies for resisting their rules and requests. Thirty mothers living in Kingston and St. Andrew, Jamaica, participated in a 1- to 1.5-h semi-structured, open-ended interview regarding their 8- to 12-year-old children. Mothers reported that their children’s resistance strategies included assertive refusal, arguing, ignoring/avoiding, attitude, and negotiation. Most mothers disapproved of their children’s actions and responded with power-assertive strategies such as physical punishment, psychological control, forced compliance, and threats. Few mothers responded with autonomy support strategies including accommodation and reasoning. The findings provided insight into the ways Jamaican children use their agency to protect their autonomy despite their mothers’ greater power, and the relational nature of children’s influence on their mothers’ behaviors and reactions. More research is needed to expand our knowledge of child agency in Afro-Caribbean families and the various ways that parents may support their growing autonomy that is socially constructive.
Effects of 3-hydroxybutyrate and free fatty acids on muscle protein kinetics and signaling during LPS-induced inflammation in humans: anticatabolic impact of ketone bodies.

Background Acute inflammation, and subsequent release of bacterial products (e.g. LPS), inflammatory cytokines, and stress hormones, is catabolic, and the loss of lean body mass predicts morbidity and mortality. Lipid intermediates may reduce protein loss, but the roles of free fatty acids (FFAs) and ketone bodies during acute inflammation are unclear. Objective We aimed to test whether infusions of 3-hydroxybutyrate (3OHB), FFAs, and saline reduce protein catabolism during exposure to LPS and Acipimox (to restrict and control endogenous lipolysis). Design A total of 10 healthy male subjects were randomly tested 3 times, with: 1) LPS, Acipimox (Olbetam) and saline, 2) LPS, Acipimox, and nonesterified fatty acids (Intralipid), and 3) LPS, Acipimox, and 3OHB, during a 5-h basal period and a 2-h hyperinsulinemic, euglycemic clamp. Labeled phenylalanine, tyrosine, and urea tracers were used to estimate protein kinetics, and muscle biopsies were taken for Western blot analysis of protein metabolic signaling. Results 3OHB infusion increased 3OHB concentrations (P < 0.0005) to 3.5 mM and decreased whole-body phenylalanine-to-tyrosine degradation. Basal and insulin-stimulated net forearm phenylalanine release decreased by >70% (P < 0.005), with both appearance and phenylalanine disappearance being profoundly decreased. Phosphorylation of eukaryotic initiation factor 2α at Ser51 was increased in skeletal muscle, and S6 kinase phosphorylation at Ser235/236 tended (P = 0.074) to be decreased with 3OHB infusion (suggesting inhibition of protein synthesis), whereas no detectable effects were seen on markers of protein breakdown. Lipid infusion did not affect phenylalanine kinetics, and insulin sensitivity was unaffected by interventions. Conclusion During acute inflammation, 3OHB has potent anticatabolic actions in muscle and at the whole-body level; in muscle, reduction of protein breakdown overrides inhibition of synthesis. This trial was registered at clinicaltrials.gov as NCT01752348.
Doxorubicin-Conjugated PAMAM Dendrimers for pH-Responsive Drug Release and Folic Acid-Targeted Cancer Therapy

We present here the development of multifunctional doxorubicin (DOX)-conjugated poly(amidoamine) (PAMAM) dendrimers as a unique platform for pH-responsive drug release and targeted chemotherapy of cancer cells. In this work, we covalently conjugated DOX onto the periphery of partially acetylated and folic acid (FA)-modified generation 5 (G5) PAMAM dendrimers through a pH-sensitive cis-aconityl linkage to form the G5.NHAc-FA-DOX conjugates. The formed dendrimer conjugates were well characterized using different methods. We show that DOX release from the G5.NHAc-FA-DOX conjugates follows an acid-triggered manner with a higher release rate under an acidic pH condition (pH = 5 or 6, close to the acidic pH of tumor microenvironment) than under a physiological pH condition. Both in vitro cytotoxicity evaluation and cell morphological observation demonstrate that the therapeutic activity of dendrimer-DOX conjugates against cancer cells is absolutely related to the DOX drug released. More importantly, the FA conjugation onto the dendrimers allowed a specific targeting to cancer cells overexpressing FA receptors (FAR), and allowed targeted inhibition of cancer cells. The developed G5.NHAc-FA-DOX conjugates may be used as a promising nanodevice for targeted cancer chemotherapy.
Exploring sequence‐based features for the improved prediction of DNA N4‐methylcytosine sites in multiple species

Motivation As one of important epigenetic modifications, DNA N4‐methylcytosine (4mC) is recently shown to play crucial roles in restriction‐modification systems. For better understanding of their functional mechanisms, it is fundamentally important to identify 4mC modification. Machine learning methods have recently emerged as an effective and efficient approach for the high‐throughput identification of 4mC sites, although high predictive error rates are still challenging for existing methods. Therefore, it is highly desirable to develop a computational method to more accurately identify m4C sites. Results In this study, we propose a machine learning based predictor, namely 4mcPred‐SVM, for the genome‐wide detection of DNA 4mC sites. In this predictor, we present a new feature representation algorithm that sufficiently exploits sequence‐based information. To improve the feature representation ability, we use a two‐step feature optimization strategy, thereby obtaining the most representative features. Using the resulting features and Support Vector Machine (SVM), we adaptively train the optimal models for different species. Comparative results on benchmark datasets from six species indicate that our predictor is able to achieve generally better performance in predicting 4mC sites as compared to the state‐of‐the‐art predictors. Importantly, the sequence‐based features can reliably and robust predict 4mC sites, facilitating the discovery of potentially important sequence characteristics for the prediction of 4mC sites. Availability and implementation The user‐friendly webserver that implements the proposed 4mcPred‐SVM is well established, and is freely accessible at http://server.malab. cn/4mcPred‐SVM. Supplementary information Supplementary data are available at Bioinformatics online.
Tumbling Into Queer Utopias and Vortexes: Experiences of LGBTQ Social Media Users on Tumblr

ABSTRACT Drawing on one year of fieldwork with LGBTQ youth, I explore the ways Tumblr, a microblogging and social networking site, has become a vibrant center of queer discourse and collectivity. I argue that for LGBTQ users, Tumblr simultaneously generates the specter of a “queer utopia”—a space where queer potential flourishes and more expansive ways to think about the future materialize—and queer “vortextuality”—an experience of being sucked into an online black hole with severe limitations. Furthermore, the user experience on the site underscores the profound vulnerability of queer individuals and communities in digital, corporatized space.
MT-Feeding-Induced Impermanent Sex Reversal in the Orange-Spotted Grouper during Sex Differentiation

In this study, we systematically investigated the process of sex reversal induced by 17-methyltestosterone (MT) feeding and MT-feeding withdrawal at the ovary differentiation stage in orange-spotted groupers, Epinephelus coioides. Gonadal histology showed that MT feeding induced a precocious sex reversal from immature ovaries to testes, bypassing the formation of an ovarian cavity, and MT-feeding withdrawal led to an ovarian fate. In both the MT feeding and MT-feeding withdrawal phases, cytochrome P450 family 11 subfamily B (cyp11b) gene expression and serum 11-KT levels were not significantly changed, suggesting that the MT-treated fish did not generate endogenous steroids, even though active spermatogenesis occurred. Finally, by tracing doublesex-expressing and Mab-3-related transcription factor 1 (dmrt1)-expressing cells and TUNEL (terminal deoxynucleotidyl transferase 2-deoxyuridine, 5-triphosphate nick end labeling) assays, we found that the efferent duct formed first, and then, the germ cells and somatic cells of the testicular tissue were generated around the efferent duct during MT-feeding-induced precocious sex reversal. Collectively, our findings provide insights into the molecular and cellular mechanisms underlying sex reversal induced by exogenous hormones during sex differentiation in the protogynous orange-spotted grouper.
High‐intensity cannabis use is associated with retention in opioid agonist treatment: a longitudinal analysis

BACKGROUND AND AIMS Cannabis use is common among people on opioid agonist treatment (OAT), causing concern for some care providers. However, there is limited and conflicting evidence on the impact of cannabis use on OAT outcomes. Given the critical role of retention in OAT in reducing opioid-related morbidity and mortality, we aimed to estimate the association of at least daily cannabis use on the likelihood of retention in treatment among people initiating OAT. As a secondary aim we tested the impacts of less frequent cannabis use. DESIGN Data were drawn from two community-recruited prospective cohorts of people who use illicit drugs (PWUD). Participants were followed for a median of 81 months (interquartile range = 37-130). SETTING Vancouver, Canada. PARTICIPANTS This study comprised a total of 820 PWUD (57.8% men, 59.4% of Caucasian ethnicity, 32.2% HIV-positive) initiating OAT between December 1996 and May 2016. The proportion of women was higher among HIV-negative participants, with no other significant differences. MEASUREMENTS The primary outcome was retention in OAT, defined as remaining in OAT (methadone or buprenorphine/naloxone-based) for two consecutive 6-month follow-up periods. The primary explanatory variable was cannabis use (at least daily versus less than daily) during the same 6-month period. Confounders assessed included: socio-demographic characteristics, substance use patterns and social-structural exposures. FINDINGS In adjusted analysis, at least daily cannabis use was positively associated with retention in OAT [adjusted odds ratio (aOR) = 1.21, 95% confidence interval (CI) = 1.04-1.41]. Our secondary analysis showed that compared with non-cannabis users, at least daily users had increased odds of retention in OAT (aOR = 1.20, 95% CI = 1.02-1.43), but not less than daily users (aOR = 1.00, 95% CI = 0.87-1.14). CONCLUSIONS Among people who use illicit drugs initiating opioid agonist treatment in Vancouver, at least daily cannabis use was associated with approximately 21% greater odds of retention in treatment compared with less than daily consumption.
The determination of the infectious status and prevalence of motile Aeromonas species isolated from disease cases in rainbow trout (Oncorhynchus mykiss) and aquarium fish.

The aims of this study were to determine the prevalence and phylogenetic relationship of motile Aeromonas spp. that might be pathogenic species for rainbow trout in infected/mix infection cases (based upon different outbreaks on fish farms). A total of 99 motile Aeromonas isolates (and three reference strains) were analysed that were isolated from four different fish species in different sizes of fish (0.1-3,000 g), different months and water temperatures (6.1-21.2°C). The biochemical characteristics of the isolates were determined using conventional tests and a rapid test kit. Additionally, molecular identification was performed using the gyrB housekeeping gene region and with glycerophospholipid-cholesterol acyltransferase polymerase chain reaction (GCAT-PCR). The sequencing results obtained from the gyrB gene region were deposited in the GenBank database, and phylogenetic relationships were determined with the BioNumerics 7.6 database. Nearly half of the Aeromonas isolates that were isolated from rainbow trout showing signs of disease were determined to be possible infectious agents. Aeromonas species exhibit biochemical variability for many characters, so some Aeromonas species tested negative for GCAT-PCR despite that this test was created especially for Aeromonas identification. The phylogenetic tree based upon gyrB contained 10 different phylogroups that were based on 96% cut-off value in gyrB gene region.
Effect of high-volume hemofiltration on mortality in critically ill patients

Background: High-volume hemofiltration (HVHF) is widely used for blood purification in critically ill patients with systemic inflammatory syndromes. The purpose of this study was to evaluate the effect of HVHF on mortality at different follow-up periods in critically ill patients. Methods: We systematically searched PubMed, Embase, and the Cochrane Library through April 2017 to identify trials that evaluated the effect of HVHF on mortality in critically ill patients. Summary relative risks (RRs) and 95% confidence intervals (CIs) were employed to calculate the treatment effect using a random effects model. Eleven trials involving 1048 critically ill patients were included in this study. Results: The summary results indicated no significant differences between HVHF and usual care for the incidence of 28-day mortality (RR: 0.93; 95%CI: 0.80–1.08; P = .321), 7-day mortality (RR: 0.72; 95%CI: 0.50–1.03; P = .072), 60-day mortality (RR: 1.00; 95%CI: 0.86–1.16; P = .997), and 90-day mortality (RR: 1.01; 95%CI: 0.88–1.16; P = .927). Subgroup analysis suggested HVHF significantly reduced the risk of 28-day mortality (RR: 0.64; 95%CI: 0.42–0.97; P = .035) if pooled the study sample size < 100. Conclusion: Our findings suggest HVHF significantly reduced the incidence of 28-day mortality when pooled the study sample size < 100. Further, HVHF had a marginal effect on the incidence of 7-day mortality.
Predictors of quality of life in young adults with congenital heart disease

AIMS The aim of this study was to identify medical and psychosocial risk factors for impaired health-related quality of life (HRQoL) and poor psychological adjustment (PA) in young adults with congenital heart disease (CHD). METHODS AND RESULTS A group of 188 patients (43% females, ages 18-30 years) with various types of CHD and 139 age-matched healthy controls (57% females) completed questionnaires assessing HRQoL, PA, social support, significant life events in the past year, education level, civil status, and employment status. Medical variables were retrieved from the patients' hospital records. Patients reported worse physical HRQoL than controls but similar mental HRQoL and PA. Female CHD patients showed worse physical and mental HRQoL and poorer PA than males. In CHD patients, a lower educational level and lower physical exercise capacity predicted lower physical HRQoL, but complexity of CHD was not related to HRQoL or PA. Less social support was associated with lower mental HRQoL and poorer PA in CHD patients. CONCLUSION Young adults with CHD have impaired physical HRQoL but normal mental HRQoL and PA. Lower physical exercise capacity, female sex, less social support, and lower educational level predict an unfavourable quality of life and PA. This subgroup of patients should be monitored more closely and provided with special psychosocial care to improve long-term outcome.
Building Context-aware Clause Representations for Situation Entity Type Classification

Capabilities to categorize a clause based on the type of situation entity (e.g., events, states and generic statements) the clause introduces to the discourse can benefit many NLP applications. Observing that the situation entity type of a clause depends on discourse functions the clause plays in a paragraph and the interpretation of discourse functions depends heavily on paragraph-wide contexts, we propose to build context-aware clause representations for predicting situation entity types of clauses. Specifically, we propose a hierarchical recurrent neural network model to read a whole paragraph at a time and jointly learn representations for all the clauses in the paragraph by extensively modeling context influences and inter-dependencies of clauses. Experimental results show that our model achieves the state-of-the-art performance for clause-level situation entity classification on the genre-rich MASC+Wiki corpus, which approaches human-level performance.
Increased tau phosphorylation follows impeded dopamine clearance in a P301L and novel P301L/COMT‐deleted (DM) tau mouse model

In Alzheimer's disease, the phosphorylation of tau is a critical event preceding the formation of neurofibrillary tangles. Previous work exploring the impact of a dopamine blocking antipsychotic on tau phosphorylation in a tau transgenic model suggested that extracellular dopamine may play a regulatory role in the phosphorylation state of tau. In order to test this hypothesis, and in order to develop a mouse model of impaired dopamine metabolism and tauopathy, an extant P301L transgenic tau model of Alzheimer's disease and a novel P301L/catechol‐O‐methyltransferase deleted model (DM mouse) were treated with the norepinephrine reuptake inhibitor reboxetine, and prefrontal dopamine concentrations and the phosphorylated state of tau was quantified. In two experiments, male and female P301L+/+//COMT+/+ and P301L+/+//COMT−/− (DM) mice were treated with reboxetine 20 mg/kg IP. In one experiment, acutely following reboxetine injection, the prefrontal cortex of mice were microdialyzed for dopamine, and its metabolites, 3,4‐dihydroxyphenylacetic acid and homovanillic acid, utilizing the MetaQuant technique. In another experiment, acutely following reboxetine injections, tau phosphorylation was quantified in the frontal cortex, striatum, and hippocampus of the mice. Reboxetine injections were followed by significant increases from baseline in extracellular dopamine concentrations in P301L and DM mice, with significantly higher peak levels in the DM mice. Treatment was also followed by increases in tau phosphorylation spread throughout brain regions, with a larger impact on female mice. Extracellular dopamine concentrations exert an influence on the phosphorylation state of tau, with surges in dopamine associating with acute increases in tau phosphorylation.