Miracle-dz/UniFAR-FTUs huggingface dataset:
Validation of cancer institute quality of life questionnaire version II for cancer patients in India.

BACKGROUND The Quality of Life (QOL) questionnaire version I consisted of 38 items that were validated using 392 patients. The experiences gained through the interaction with the patients during the administration of the questionnaire provided a lot of inputs for the improvization of the tool. AIM The current study is aimed at certain modifications of the QOL questionnaire version I and standardization of the same. MATERIALS AND METHODS The modifications of version I QOL scale included the change of verbatim, splitting, deleting, and adding of new items. Finally, version II included 42 items. It was administered to 183 cancer patients irrespective of their demographic details for further standardization. STATISTICS The principal component method with varimax rotation was used. Spearman's product moment correlation and Cronbach's alpha coefficient were used for reliability analysis. RESULTS The data were subjected to factor analysis to explore the factors. Eleven factors emerged with the eigenvalue ranging from 8.03 to 1.10 and accounted for 66.7% variance. The first factor contributed maximally, 19.5%, and the remaining 10 factors contributed a total of 46.2% variance on QOL. They are general well-being, physical well-being, psychological well-being, familial relationship, sexual and personal ability, cognitive well-being, optimism and belief, economical well-being, information support, patient-physician relationship, and body image. The Cronbach alpha of 0.90 and split-half reliability of 0.80 indicated a high reliability of the tool. CONCLUSION The factor structure showed that QOL is a multidimensional concept having different aspects. The Cancer Institute QOL Questionnaire version II for cancer patients is found to be a valid and reliable tool and feasible to administer at the clinical settings.
The psychosocial treatment of schizophrenia: an update.

OBJECTIVE The authors sought to update the randomized controlled trial literature of psychosocial treatments for schizophrenia. METHOD Computerized literature searches were conducted to identify randomized controlled trials of various psychosocial interventions, with emphasis on studies published since a previous review of psychosocial treatments for schizophrenia in 1996. RESULTS Family therapy and assertive community treatment have clear effects on the prevention of psychotic relapse and rehospitalization. However, these treatments have no consistent effects on other outcome measures (e.g., pervasive positive and negative symptoms, overall social functioning, and ability to obtain competitive employment). Social skills training improves social skills but has no clear effects on relapse prevention, psychopathology, or employment status. Supportive employment programs that use the place-and-train vocational model have important effects on obtaining competitive employment. Some studies have shown improvements in delusions and hallucinations following cognitive behavior therapy. Preliminary research indicates that personal therapy may improve social functioning. CONCLUSIONS Relatively simple, long-term psychoeducational family therapy should be available to the majority of persons suffering from schizophrenia. Assertive community training programs ought to be offered to patients with frequent relapses and hospitalizations, especially if they have limited family support. Patients with schizophrenia can clearly improve their social competence with social skills training, which may translate into a more adaptive functioning in the community. For patients interested in working, rapid placement with ongoing support offers the best opportunity for maintaining a regular job in the community. Cognitive behavior therapy may benefit the large number of patients who continue to experience disabling psychotic symptoms despite optimal pharmacological treatment.
SNAP-23 Requirement for Transferrin Recycling in StreptolysinO-permeabilized Madin-Darby Canine Kidney Cells*

Fusion of recycling and transcytotic vesicles with the apical and basolateral plasma membrane domains of Madin-Darby canine kidney (MDCK) cells requires theN-ethylmaleimide-sensitive factor and is sensitive to botulinum neurotoxin serotype E (BoNT/E). BoNT/E is thought to selectively proteolyze the 25,000-dalton synaptosomal associated protein (SNAP-25), a protein found in neurons or cells of neuroendocrine origin. However, SNAP-25 is not found in MDCK cells. One possible target for BoNT/E in MDCK cells is SNAP-23, a newly described SNAP-25 homolog that is found in several organs including kidney. Currently, the function of SNAP-23 is unknown. We have reconstituted transferrin recycling in permeabilized MDCK cells to assess the role of SNAP-23 in the endocytic traffic of this protein. We find that: (i) SNAP-23 is expressed in MDCK cells and is found both at the basolateral plasma membrane and associated with apical and basolateral vesicles, (ii) canine SNAP-23 is cleaved by BoNT/E, (iii) transferrin recycling is N-ethylmaleimide-sensitive factor-dependent and BoNT/E-sensitive, and (iv) addition of either exogenous SNAP-23 or anti-SNAP-23 antibodies inhibits ligand recycling. Our observations suggest that SNAP-23 may be required for fusion of recycling vesicles with the basolateral membrane of polarized MDCK cells.
Productivity, profitability and employment generation in integrated farming systems for rainfed vertisols of western zone of Tamil Nadu

A study was conducted at Coimbatore during July 2000 to July 2002 to find out suitable farming system for small and marginal farmers of rainfed vertisols of the western zone of Tamil Nadu. All enterprise combinations tried were profitable compared with conventional practice of cropping alone. The integration of crop (0.80 ha) fertilized with buffalo manure produced on the farm, with pigeon (10 pairs on 0.01 ha), goat (5 + 1 female + male on 0.02 ha), buffalo (2 milking buffaloes + 1 calf on 0.03 ha), agroforestry (0.10 ha) and farm pond (0.04 ha) was found to be the most profitable farming system on a holistic basis. Recycling of resources and residues led to higher pro- ductivity, employment and income generation with this enterprise combination. For small and marginal farmers who are short of cash, integration of crop (0.80 ha) with pigeon (10 pairs on 0.01 ha), goat (5 + 1 female + male on 0.05 ha), agroforestry (0.10 ha) and farm pond (0.04 ha) was found to be a good alternative farming system with recycling of composted goat manure to the crop.
Palmitate-induced Apoptosis Can Occur through a Ceramide-independent Pathway*

Cytotoxic accumulation of long chain fatty acids has been proposed to play an important role in the pathogenesis of diabetes mellitus and heart disease. To explore the mechanism of cellular lipotoxicity, we cultured Chinese hamster ovary cells in the presence of media supplemented with fatty acid. The saturated fatty acid palmitate, but not the monounsaturated fatty acid oleate, induced programmed cell death as determined by annexin V positivity, caspase 3 activity, and DNA laddering. De novo ceramide synthesis increased 2.4-fold with palmitate supplementation; however, this was not required for palmitate-induced apoptosis. Neither biochemical nor genetic inhibition of de novo ceramide synthesis arrested apoptosis in Chinese hamster ovary cells in response to palmitate supplementation. Rather, our data suggest that palmitate-induced apoptosis occurs through the generation of reactive oxygen species. Fluorescence of an oxidant-sensitive probe was increased 3.5-fold with palmitate supplementation indicating that production of reactive intermediates increased. In addition, palmitate-induced apoptosis was blocked by pyrrolidine dithiocarbamate and 4,5-dihydroxy-1,3-benzene-disulfonic acid, two compounds that scavenge reactive intermediates. These studies suggest that generation of reactive oxygen species, independent of ceramide synthesis, is important for the lipotoxic response and may contribute to the pathogenesis of diseases involving intracellular lipid accumulation.
The Analysis Of Political Marketing Mix In Influencing Image And Reputation Of Political Party And Their Impact Toward The Competitiveness Of Political Party (The Survey Of Voters In West Java Province)

Recently in Indonesia, public trust toward political parties has been decreasing. Most voters tend to be neutral, they had better to choose to none. The Experts argued that political competitivness will be high when political parties apply the accurate marketing mix or enhance their image and reputation. The aim of this research is to show how far political marketing mix in influencing the image or the reputation of political party and their impact toward the competitivness of 10 political parties conducted in Province West Java. I use quantitative method with explanatory survey method design. The population in this research is all voters in West Java, while the samples are about 400 persons with cluster random sampling. Data analysis in this research is descriptive with Parsial Least Square (PLS) hypothesis test. PLS describes political marketing mix toward the image and the reputation of political party and their impact toward the competitivness of political party. The result shows that independent variable (X), political marketing mix, gives a positive and significant influence to intervening variables (Y1) and (Y2), the image and the reputation of political party, and dependent variable (Y3), political party competitivness, their impact to the variable depend on it. The finding in this study is that marketing mix has high influence toward the competitiveness of political party by enhancing the image and the reputation of political party.
In-Field Peduncle Detection of Sweet Peppers for Robotic Harvesting: a comparative study

Robotic harvesting of crops has the potential to disrupt current agricultural practices. A key element to enabling robotic harvesting is to safely remove the crop from the plant which often involves locating and cutting the peduncle, the part of the crop that attaches it to the main stem of the plant. In this paper we present a comparative study of two methods for performing peduncle detection. The first method is based on classic colour and geometric features obtained from the scene with a support vector machine classifier, referred to as PFH-SVM. The second method is an efficient deep neural network approach, MiniInception, that is able to be deployed on a robotic platform. In both cases we employ a secondary filtering process that enforces reasonable assumptions about the crop structure, such as the proximity of the peduncle to the crop. Our tests are conducted on Harvey, a sweet pepper harvesting robot, and is evaluated in a greenhouse using two varieties of sweet pepper, Ducati and Mercuno. We demonstrate that the MiniInception method achieves impressive accuracy and considerably outperforms the PFH-SVM approach achieving an F1 score of 0.564 and 0.302 respectively.
Speaking modifies voice‐evoked activity in the human auditory cortex

The voice we most often hear is our own, and proper interaction between speaking and hearing is essential for both acquisition and performance of spoken language. Disturbed audiovocal interactions have been implicated in aphasia, stuttering, and schizophrenic voice hallucinations, but paradigms for a noninvasive assessment of auditory self‐monitoring of speaking and its possible dysfunctions are rare. Using magnetoencephalograpy we show here that self‐uttered syllables transiently activate the speaker's auditory cortex around 100 ms after voice onset. These phasic responses were delayed by 11 ms in the speech‐dominant left hemisphere relative to the right, whereas during listening to a replay of the same utterances the response latencies were symmetric. Moreover, the auditory cortices did not react to rare vowel changes interspersed randomly within a series of repetitively spoken vowels, in contrast to regular change‐related responses evoked 100–200 ms after replayed rare vowels. Thus, speaking primes the human auditory cortex at a millisecond time scale, dampening and delaying reactions to self‐produced “expected” sounds, more prominently in the speech‐dominant hemisphere. Such motor‐to‐sensory priming of early auditory cortex responses during voicing constitutes one element of speech self‐monitoring that could be compromised in central speech disorders. Hum. Brain Mapping 9:183–191, 2000. © 2000 Wiley‐Liss, Inc.
The Pharmacokinetics of Antiepileptic Drugs in Rats: Consequences for Maintaining Effective Drug Levels during Prolonged Drug Administration in Rat Models of Epilepsy

Summary: Rodent models of chronic epilepsy with spontaneous recurrent seizures likely represent the closest parallel to the human condition. Such models may be best suited for therapy discovery for pharmacoresistant epilepsy and for antiepileptogenic or disease‐modifying therapeutics. However, the use of such rodent models for therapy discovery creates problems with regard to maintaining effective drug levels throughout a prolonged testing period. This is particularly due to the fact that rodents such as rats and mice eliminate most drugs much more rapidly than humans. Thus, knowledge about elimination rate of a test drug in a laboratory species is essential for development of a treatment paradigm that allows maintaining adequate drug levels in the system over the period of treatment. Currently, the most popular models of epilepsy with spontaneous seizures are poststatus epilepticus models of temporal lobe epilepsy in rats. Such models are both used for studies on antiepileptogenesis and drug resistance. For validation of these models, current antiepileptic drugs (AEDs) have to be used. In this article, the elimination rates of these AEDs and their effective plasma levels in rats are reviewed as a guide for developing treatment protocols for chronic drug testing. The advantages and disadvantages of several technologies for drug delivery are discussed, and some examples for calculation of adequate treatment protocols are given. As shown in this review, because of the rapid elimination of most AEDs in rats, it is no trivial task to maintain effective steady‐state AED levels in the plasma throughout the day over multiple days to ensure that there will be adequate levels in the system for the purpose of the experiment. However, the use of an adequate dosing regimen that is based on elimination rate is an absolute prerequisite when using rat models for discovery of new antiepileptogenic therapies or therapies for pharmacoresistant epilepsy, because otherwise such models may lead to erroneous conclusions about drug efficacy.
Academics or Entrepreneurs? Entrepreneurial Identity and Invention Disclosure Behavior of University Scientists

We conceptualize the nascent process of becoming an entrepreneur as a role identity transformation and investigate the factors that influence an individual's decision to assume an entrepreneurial identity. We collected more than 70 hours of interview data in addition to a survey of 796 scientists at a premier research university. Our results reveal that perceived social and economic enablers, institutional support and perceived impediments play a significant role in the willingness of scientists to adopt an entrepreneurial role identity and engage in technology commercialization activity, measured by the level of invention disclosure. Interestingly, entrepreneurial intent to start a business did not have a significant main effect on the level of disclosure activity. Our findings provide a deeper understanding of the social psychological dynamics underlying nascent entrepreneurial activity as it relates to the factors enabling or impeding the adoption of role identities. This study also informs the rich dialog in the science policy and academic entrepreneurship literatures.
Characteristics of children hospitalized with severe dehydration and persistent diarrhoea in Bangladesh.

The study analyzed data from a systematic sample of children, aged less than five years, who presented with persistent diarrhoea (diarrhoea of more than 14 days duration). It aims to differentiate (a) non-severe persistent diarrhoea (with no or mild dehydration) and (b) severe persistent diarrhoea (with moderate or severe dehydration), and to identify individual characteristics associated with severe persistent diarrhoea. In total, 7,505 patients, who represented a 4% systematic sample of the patient population, were seen during January 1993-December 1995. Of them, 297 (4%) presented with persistent diarrhoea. The male:female ratio was 2:1. Eighty-three percent of them had mild or no dehydration, and 17% had moderate or severe dehydration. Severe malnutrition of the study patients defined as weight-for-age z-score < -3, weight-for-length z-score < -3 and length-for-age z-score < -3 were 33.9%, 9.7%, and 22.7% respectively. Only 3% had oedematous malnutrition, and 11% had xerophthalmia. Factors independently associated with severe persistent diarrhoea by logistic regression analyses were: number of watery stool > 10 times during the last 24 hours prior to admission (OR, 10.0; CI, 1.2-87, p = 0.03), lower respiratory tract infection (OR, 111; CI, 4.2-2955, p = 0.004), and lack of mothers' education (OR, 7.8; CI, 1.4-41.9, p = 0.016) after controlling for confounders. Awareness and health education of mothers or caregivers and better case management during acute diarrhoeal episode might prevent the development of severe persistent diarrhoea in young children. In addition, children with severe persistent diarrhoea might need special attention to have adequate rehydration and control of extraintestinal infections, including respiratory tract infection.
Modulation of Premotor and Primary Motor Cortical Activity during Volitional Adjustments of Speed-Accuracy Trade-Offs

Recent work suggests that while animals decide between reaching actions, neurons in dorsal premotor (PMd) and primary motor (M1) cortex reflect a dynamic competition between motor plans and determine when commitment to a choice is made. This competition is biased by at least two sources of information: the changing sensory evidence for one choice versus another, and an urgency signal that grows over time. Here, we test the hypothesis that the urgency signal adjusts the trade-off between speed and accuracy during both decision-making and movement execution. Two monkeys performed a reaching decision task in which sensory evidence continuously evolves over the course of each trial. In different blocks, task timing parameters encouraged monkeys to voluntarily adapt their behavior to be either hasty or conservative. Consistent with our hypothesis, during the deliberation process the baseline and gain of neural activity in decision-related PMd (29%) and M1 cells (45%) was higher when monkeys applied a hasty policy than when they behaved conservatively, but at the time of commitment the population activity was similar across blocks. Other cells (30% in PMd, 30% in M1) showed activity that increased or decreased with elapsing time until the moment of commitment. Movement-related neurons were also more active after longer decisions, as if they were influenced by the same urgency signal controlling the gain of decision-related activity. Together, these results suggest that the arm motor system receives an urgency/vigor signal that adjusts the speed-accuracy trade-off for decision-making and movement execution. SIGNIFICANCE STATEMENT This work addresses the neural mechanisms that control the speed-accuracy trade-off in both decisions and movements, in the kinds of dynamic situations that are typical of natural animal behavior. We found that many “decision-related” premotor and motor neurons are modulated in a time-dependent manner compatible with an “urgency” signal that changes between hasty and conservative decision policies. We also found that such modulation influenced cells related to the speed of the reaching movements executed by the animals to report their decisions. These results suggest that a unified mechanism determines speed-accuracy trade-off adjustments during decision-making and movement execution, potentially influencing both the cognitive and motor aspects of reward-oriented behavior.
Hepatitis B virus and hiv infections among patients in Mulago hospital.

OBJECTIVE To compare the frequency of exposure to hepatitis B infection among HIV seropositive and HIV seronegative medical outpatients. DESIGN Case control study. SETTING Mulago hospital medical outpatient clinics. PATIENTS One hundred and twenty nine consecutive HIV seropositive patients and one hundred and twenty nine HIV seronegative control patients. RESULTS The frequency of anti-HBc among the HIV seropositive patients was 65.1% compared to 41.9% in the HIV seronegative patients (95% confidence interval: 1.51-4.45; p-value: 0.0002). Of the 84 HIV positive patients with anti-HBc, 52 (61.9%) had more than five lifetime sexual partners. In comparison, of the 45 HIV positive patients with no anti-HBc, only 18 (40%) had more than five lifetime sexual partners (95% confidence interval: 1.04-1.80; p-value: 0.028). There was no significant difference in the frequency of HBsAg and HBeAg among the HIV seropositives and HIV seronegatives. CONCLUSION The frequency of previous exposure to hepatitis B infection was higher among HIV seropositive patients compared with HIV seronegative patients and was associated with a greater number of lifetime sexual partners. Safe sexual behaviour and reduction in the number of sexual partners should continue to be promoted in the community including HIV positive patients, because it is likely to have the added advantage of reducing coincident exposure to HBV infection. This is especially important for the immunocompromised HIV positive patients who are more likely to develop a chronic infectious carrier state and among whom HBV control by vaccination is less effective than in the immunocompetent individuals.
Charge effects on particle deposition in the human tracheobronchial tree.

Electrification occurs in most aerosol generating processes. The unipolar charges carried by these particles can influence the deposition of inhaled particles in the lungs. Recently published studies using a hollow lung cast of a human larynx-tracheobronchial tree and in vivo experiments in human subjects have demonstrated that increased deposition was due to electrostatic charges on the particle. The electrostatic charge effect on deposition may be important in the assessment of hazards associated with charged particles and was therefore studied theoretically. A new model was developed to predict particle deposition in the bronchial airways due to the combined mechanisms of inertial and electrostatic image forces. The agreement between the predicted values and the experimental data suggests that the new theory can be used to estimate tracheobronchial deposition of charged particles in the human respiratory tract.