Miracle-dz/UniFAR-FTUs huggingface dataset:
A Resource Allocation Framework for Network Slicing

Telecommunication networks are converging to a massively distributed cloud infrastructure interconnected with software defined networks. In the envisioned architecture, services will be deployed flexibly and quickly as network slices. Our paper addresses a major bottleneck in this context, namely the challenge of computing the best resource provisioning for network slices in a robust and efficient manner. With tractability in mind, we propose a novel optimization framework which allows fine-grained resource allocation for slices both in terms of network bandwidth and cloud processing. The slices can be further provisioned and auto-scaled optimally based on a large class of utility functions in real-time. Furthermore, by tuning a slice-specific parameter, system designers can trade off traffic-fairness with computing-fairness to provide a mixed fairness strategy. We also propose an iterative algorithm based on the alternating direction method of multipliers (ADMM) that provably converges to the optimal resource allocation and we demonstrate the method's fast convergence in a wide range of quasi-stationary and dynamic settings.
Suicide and Accidental Death for Australia’s Farming Families: How Context Influences Individual Response

This article presents qualitative data to explore the experience of farming family members faced with accidental or suicide death and understand how this is experienced within the farming context. Individual semistructured interviews were conducted with 25 members of Australian farming families bereaved by suicide or accidental death. Qualitative data was thematically analyzed. Three interconnected themes were identified: acceptance of risk, normalization of death, pragmatic behavior patterns and connection to place. Bereavement and reconstruction of meaning following suicide or accidental death for farming families is influenced by the cultural, social, geographical, and psychological contexts of farming families. This article challenges traditional conceptions of suicide and accidental death as necessarily experienced as “violent” or “traumatic,” bereavement as experienced similarly across western cultures, and the reaction to suicide or accidental death as one that challenges people’s understanding of their world and leaves them struggling to find a reason why the death occurred.
Genetic diversity in Undaria pinnatifida (Laminariales, Phaeophyceae) deduced from mitochondria genes – origins and succession of introduced populations

S. Uwai, W. Nelson, K. Neill, W.D. Wang, L.E. Aguilar-Rosas, S.M. Boo, T. Kitayama and H. Kawai. 2006. Genetic diversity in Undaria pinnatifida (Laminariales, Phaeophyceae) deduced from mitochondria genes – origins and succession of introduced populations. Phycologia 45: 687–695. DOI: 10.2216/05-66.1 To elucidate the genetic diversity of the brown alga Undaria pinnatifida in native and introduced populations worldwide, and to discuss the transoceanic introduction processes, we investigated the haplotype divergence of the mitochondrial loci of the coding region of cox3 and noncoding region between tatC and tLeu genes. In its native range (Japan, Korea and China), we found 27 haplotypes, which were classified into 4 genetic and biogeographical groups: (1) Northern Japan type, distributed in Hokkaido and Pacific northern Honshu; (2) Continental type, found in Korea and China; (3) Pacific central Japan type; and (4) Sea of Japan type. Among the introduced populations, European and Mexican populations agreed with the Northern Japan type. In Australia, the Tasmanian population agreed with the Sea of Japan type, whereas the Victorian population was of the Continental type. Very high diversities were found in New Zealand: 10 haplotypes were found (including 2 only in old herbarium specimens), including both the Northern Japan type and the Continental type. The haplotype found in California agreed with a component of the Central Japan type collected at Kanagawa Prefecture. The samples from Argentina agreed with the Continental type. The alignment of the European populations with the Northern Japan type is consistent with the notion that the Undaria in Europe was first introduced with oyster spat. It is speculated that Californian and Mexican populations were recently introduced by shipping vectors. There have been many introduction events to New Zealand since the late 1980s, and the dominant haplotypes in the local populations appear to have changed over time. Introduction to Argentina/Australia (Victoria) could have resulted from secondary introductions from New Zealand populations, because transport within the same latitudinal range is considered to be easier than transport by shipping across the equator. Within Japan, the occurrence of both the Continental and the Northern Japan types in the Osaka Bay area is considered to be the result of recent intentional introduction for fisheries purposes.
Lymphocyte Subsets and Inflammatory Cytokines of Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma

Almost all multiple myeloma (MM) cases have been demonstrated to be linked to earlier monoclonal gammopathy of undetermined significance (MGUS). Nevertheless, there are no identified characteristics in the diagnosis of MGUS that have been helpful in differentiating subjects whose cancer may progress to a malignant situation. Regarding malignancy, the role of lymphocyte subsets and cytokines at the beginning of neoplastic diseases is now incontestable. In this review, we have concentrated our attention on the equilibrium between the diverse lymphocyte subsets and the cytokine system and summarized the current state of knowledge, providing an overview of the condition of the entire system in MGUS and MM. In an age where the therapy of neoplastic monoclonal gammopathies largely relies on drugs capable of acting on the immune system (immunomodulants, immunological checkpoint inhibitors, CAR-T), detailed knowledge of the the differences existing in benign and neoplastic forms of gammopathy is the main foundation for the adequate and optimal use of new drugs.
Birth Parents: Blogging The Emotional Journey Through Adoption

Adoption often focuses on the adoptive parents and the child. Birth parents are frequently forgotten about even though the adoption process would not be possible without them. This study looks at the birth parents’ experiences and the emotions they often endure. A textual analysis research design was used to gain insight into the birth parents’ journey though the adoption process, using blogs written by birth mothers and birth fathers. Four blogs were studied with two written by birth mothers and two authored by birth fathers. Qualitative analysis was applied through grounded theory which utilizes coding to deciphering themes. This study brought to light the themes of a) identity, b) relationships with the subthemes of intimacy and support, c) “It’s a hard line to tow” that includes, guilt/shame and stigma, d) “Utter devastation” which incorporates grief and loss, and e) alienation that consists of rejection, loss of control, and being misunderstood. The findings support the previous literature and have implications for future social work practice.
Preventative effects of aripiprazole and quetiapine on seizure and lethality in a mice cocaine toxicity model: an experimental study

Objective To assess the effectiveness of pre-treatment with aripiprazole and quetiapine to prevent acute cocaine toxicity in a mouse model of cocaine toxicity. Methods This experimental study included three groups (n = 25 per group) of mice that were intraperitoneally injected with normal saline solution, 10 mg/kg quetiapine or 10 mg/kg aripiprazole 15 min before 105 mg/kg cocaine hydrochloride. When the cocaine administration was completed, researchers blinded to the study groups observed the mice in terms of seizures and death for a further 30 min. Results In the cocaine + quetiapine group, the mean ± SE time to the first seizure was 10.80 ± 2.27 min and seizure activity was detected in 18 mice (72%) by the end of the 30 min. In the cocaine + aripiprazole group, the mean ± SE time to the first seizure was 18.10 ± 1.94 min and seizure activity was detected in 15 mice (60%) by the end of the 30 min. When compared with the control group, there was a significant difference between the cocaine + quetiapine and cocaine + aripiprazole groups in terms of seizure activity. Survival time was increased in the cocaine + aripiprazole group compared with the control and cocaine + quetiapine groups. Conclusion Quetiapine and aripiprazole pre-treatment reduced seizure activity and delayed the onset of seizures compared with the control group.
Data Mining for AMD Screening: A Classification Based Approach

© 2014, UK Simulation Society. All rights reserved. This paper investigates the use of three alternative approaches to classifying retinal images. The novelty of these approaches is that they are not founded on individual lesion segmentation for feature generation, instead use encodings focused on the entire image. Three different mechanisms for encoding retinal image data were considered: (i) time series, (ii) tabular and (iii) tree based representations. For the evaluation two publically available, retinal fundus image data sets were used. The evaluation was conducted in the context of Age-related Macular Degeneration (AMD) screening and according to statistical significance tests. Excellent results were produced: Sensitivity, specificity and accuracy rates of 99% and over were recorded, while the tree based approach has the best performance with a sensitivity of 99.5%. Further evaluation indicated that the results were statistically significant. The excellent results indicated that these classification systems are ideally suited to large scale AMD screening processes.
Influence of human histocompatibility antigens on susceptibility to and clinical expression of psychiatric diseases

Understanding the molecular basis of diseases is increasingly more important for their diagnosis, prevention, and treatment. Located in the short arm of chromosome 6, the human histocompatibility system – human leukocyte antigens (HLA) – participates in the pathogenesis of some psychiatric disorders. Development of new molecular methods to typify HLA alleles and recent nomenclature updates have been contributing to a better understanding of this system. Unfortunately, this information has not been adequately disclosed in the medical literature. This article aims to review HLA structure, antigen function, detection methods, and current nomenclature, as well as to describe its association with schizophrenia, bipolar disorder, and autism. Articles published between 1995 and 2005 (to reflect the most recent knowledge of the subject) were searched in the MEDLINE and LILACS databases. It is concluded that HLA antigens
MIXED FINITE ELEMENT METHODS: IMPLEMENTATION WITH ONE UNKNOWN PER ELEMENT, LOCAL FLUX EXPRESSIONS, POSITIVITY, POLYGONAL MESHES, AND RELATIONS TO OTHER METHODS

In this paper, we study the mixed finite element method for linear diffusion problems. We focus on the lowest-order Raviart–Thomas case. For simplicial meshes, we propose several new approaches to reduce the original indefinite saddle point systems for the flux and potential unknowns to (positive definite) systems for one potential unknown per element. Our construction principle is closely related to that of the so-called multi-point flux-approximation method and leads to local flux expressions. We present a set of numerical examples illustrating the influence of the elimination process on the structure and on the condition number of the reduced matrix. We also discuss different versions of the discrete maximum principle in the lowest-order Raviart–Thomas method. Finally, we recall mixed finite element methods on general polygonal meshes and show that they are a special type of the mimetic finite difference, mixed finite volume, and hybrid finite volume family.
Characterization of Silver Nanoparticles Synthesizing Bacteria and Its Possible Use in Treatment of Multi Drug Resistant Isolate

Nanobiotechnology is apromisingarea to cater human life. Biological methods for the synthesis of silver nanoparticles are relatively cost effective process. It was aimed at synthesizing silver nanoparticles using water and soil borne bacterial isolates, characterization of silver nanoparticles using UV-Vis spectroscopy and Fourier transform infra red (FTIR) spectroscopy and its effect on multi drug resistant bacterial isolate. The biosynthesis of silver nanoparticles was evaluated in both bacterial biomass and culture supernatant of Bacillus, Pseudomonas and Escherichia coli in the presence of 1mM of AgNO 3 . On the basis of physical appearances of silver nano particles, Pseudomonas sp. was selected for synthesis. The absorbance spectra of reaction mixture of bacterial biomass and supernatant show the strong peak at 420 nm, indicating the presence of silver nanoparticles (AgNPs) using UV-Vis and FTIR spectrophotometry. The influence of synthesized AgNPs wastested against multi drug resistant (MDR) Staphylococcus sp. on Mueller Hinton agar. The multi antibiotics resistant Staphylococcus sp. Showe dantibiotic sensitivity against the antibiotic discs impregnated with silver nanoparticles. The characteristics of silver nanoparticlesrevealedits possible use in biomedical field.
Is higher resilience predictive of lower stress and better mental health among corporate executives?

Objective To assess the impact of resilience, the ability to withstand and bounce back from adversity, on measures of well-being, self-reported stress, and mental health diagnoses. Methods This study was a cross-sectional survey of participants seen at an executive health practice at Mayo Clinic, Rochester, Minnesota, from January 2012 through September 2016. Participants completed an anonymous survey that included demographic information and 3 validated survey instruments—the 10-item Connor-Davidson Resilience Scale (CD-RISC), the 12-item Linear Analogue Self-Assessment Scale (LASA), and the 14-item Perceived Stress Scale (PSS). Self-reported history of mental health diagnoses was also collected. CD-RISC scores were used to stratify participants into lower (<30), medium (30–34), or higher (≥35) resilience categories. Participants’ LASA scores, PSS scores, and self-reported mental health diagnoses were compared among resilience categories. Results Of the 2,027 eligible participants, 1,954 met the study inclusion criteria as currently employed corporate-sponsored executive or business professionals (self-designated) who completed the CD-RISC survey. Most participants (62.5%) were aged 40 to 59 years. The majority were male (78.3%), white (95.3%), educated (86.2%), and in a committed relationship (89.7%). Among participants, 41.7% reported higher resilience, 34.3% had medium resilience, and 24.0% had lower resilience. The quality of life and overall LASA scores were positively associated with higher resilience (P < .001). PSS scores and self-reported mental health diagnoses were negatively associated with higher resilience (P < .001). These associations remained significant after adjusting for patient characteristics. Conclusions In this cross-sectional survey of a large cohort of corporative executives, the lower-resilience cohort had a 4-fold higher prevalence of depression and an almost 3-fold higher prevalence of anxiety compared with the higher-resilience cohort. High resilience was positively associated with well-being and negatively associated with perceived stress. Our findings suggest that higher resilience in the executive workplace environment is associated with better mental health, reduced stress, and greater well-being.
CW-pumped single-pass frequency comb generation by resonant optomechanical nonlinearity in dual-nanoweb fiber

Recent experiments in the field of strong optomechanical interactions have focused on either structures that are simultaneously optically and mechanically resonant, or photonic crystal fibers pumped by a laser intensity modulated at a mechanical resonant frequency of the glass core. Here, we report continuous-wave (CW) pumped self-oscillations of a fiber nanostructure that is only mechanically resonant. Since the mechanism has close similarities to stimulated Raman scattering by molecules, it has been named stimulated Raman-like scattering. The structure consists of two submicrometer thick glass membranes (nanowebs), spaced by a few hundred nanometers and supported inside a 12-cm-long capillary fiber. It is driven into oscillation by a CW pump laser at powers as low as a few milliwatts. As the pump power is increased above threshold, a comb of Stokes and anti-Stokes lines is generated, spaced by the oscillator frequency of ∼6 MHz. An unprecedentedly high Raman-like gain of ∼4×106 m−1 W−1 is inferred after analysis of the experimental data. Resonant frequencies as high as a few hundred megahertz are possible through the use of thicker and less-wide webs, suggesting that the structure can find application in passive mode-locking of fiber lasers, optical frequency metrology, and spectroscopy.
DNA barcoding a complete matrix of stereoisomeric small molecules.

It is challenging to incorporate stereochemical diversity and topographic complexity into DNA-encoded libraries (DELs) because DEL syntheses cannot fully exploit the capabilities of modern synthetic organic chemistry. Here, we describe the design, construction, and validation of DOS-DEL-1, a library of 107,616 DNA-barcoded chiral 2,3-disubsituted azetidines and pyrrolidines. We used stereospecific C-H arylation chemistry to furnish complex scaffolds primed for DEL synthesis, and we developed an improved on-DNA Suzuki reaction to maximize library quality. We then studied both the structural diversity of the library and the physicochemical properties of individual compounds using Tanimoto multi-fusion similarity analysis, among other techniques. These analyses revealed not only that most DOS-DEL-1 members have "drug-like" properties, but also that the library more closely resembles compound collections derived from diversity synthesis than those from other sources ( e.g., commercial vendors). Finally, we performed validation screens against horseradish peroxidase and carbonic anhydrase IX, and we developed a novel, Poisson-based statistical framework to analyze the results. A set of assay positives were successfully translated into potent carbonic anhydrase inhibitors (IC50 = 20.1-68.7 nM), which confirmed the success of the synthesis and screening procedures. These results establish a strategy to synthesize DELs with scaffold-based stereochemical diversity and complexity that does not require the development of novel DNA-compatible chemistry.
Overexpression of the long non-coding RNA Oprm1 alleviates apoptosis from cerebral ischemia-reperfusion injury through the Oprm1/miR-155/GATA3 axis

Abstract Numerous differentially expressed long non-coding RNAs (lncRNAs) have been identified in cerebral ischemia-reperfusion (I/R) injury using RNA-Seq analysis. However, little is known about whether and how lncRNAs are involved in cerebral I/R injury. In this study, we investigated the function of the lncRNA Oprm1 in cerebral I/R injury and explored the underlying mechanism. An oxygen-glucose deprivation model in N2a cells was utilized to mimic cerebral I/R injury in vitro. Trypan blue staining, terminal deoxytransferase-mediated dUTP-biotin nick end labelling and caspase-3 were measured to evaluate apoptosis. Middle cerebral artery occlusion was performed in mice to evaluate the function of lncRNA Oprm1 in vivo. Real-time PCR and western blotting were used to measure the expression levels of lncRNA Opmr1, caspase-3, miR-155, GATA binding protein 3 (GATA3) and nuclear factor (NF)-κB. lncRNA Oprm1 was mainly located in the cytoplasm. Overexpression of lncRNA Oprm1 alleviated the apoptosis induced by oxygen-glucose deprivation and significantly reduced cleaved caspase-3 levels. Infarct size was distinctly decreased in the lncRNA Oprm1-overexpression group. The neurological score was also improved. Our findings showed that the lncRNA Oprm1/miR-155/GATA3 axis plays an important role in cerebral I/R injury. lncRNA Oprm1 may attenuate cerebral injury through the NF-κB pathway. lncRNA Oprm1 may serve as a potential target for new therapeutic interventions in patients with ischemic stroke.
Pseudoexfoliative Glaucoma, Endothelial Dysfunction, and Arterial Stiffness: The Role of Circulating Apoptotic Endothelial Microparticles

Supplemental Digital Content is available in the text. Précis: Pseudoexfoliative glaucoma (PExG) patients present with not only endothelial dysfunction and arterial stiffness but also with a specific profile of circulating apoptotic endothelial microparticles which may be owing to the accumulation of pseudoexfoliative material in vessels walls. Purpose: PExG is characterized by the deposition of pseudoexfoliative material in several tissues and organs including in the cardiovascular system. This study aimed to evaluate the vascular endothelial function, arterial stiffness, inflammatory status, and circulating microparticle (MP) levels in PExG patients compared with those in primary open-angle glaucoma (POAG) patients and control subjects. Methods: Vascular endothelial function was evaluated by flow-mediated dilation. Pulse wave velocity and augmentation index were measured as indices of aortic stiffness and arterial wave reflections, respectively. Growth-differentiation factor-15 and intercellular adhesion molecule1 levels were measured to evaluate the systemic inflammatory status. Circulating MPs that constitute an emerging marker of vascular endothelial dysfunction and platelet activation were isolated and analyzed by flow cytometry. Results: There was a stepwise impairment from the control to the POAG patients and PExG subjects in the flow-mediated dilation (8.21%±2.94% vs. 7.56%±3.12% vs. 5.79±3.13, P=0.005), pulse wave velocity (8.14±1.79 vs. 9.21±2.27 vs. 9.95±3.28 m/s, P=0.007), augmentation index (24.71%±7.84% vs. 26.78%±7.21% vs. 29.96%±7.58%, P=0.02), and growth-differentiation factor-15 (P=0.001) and intercellular adhesion molecule1 levels (P=0.08). PExG patients expressed greater levels of total circulating MPs (Annexin V+) (P=0.004) and endothelial-derived MPs (CD144+) (P<0.001) compared with POAG and control subjects. Conclusions: PExG patients with an accumulation of pseudoexfoliative microfibrillar material presented with vascular endothelial dysfunction and arterial wall impairment associated with the levels of circulating proinflammatory molecules and circulating apoptotic endothelial MPs. These findings highlight the underlying systemic pathophysiological mechanisms associated with the progress of the pseudoexfoliative syndrome.