Miracle-dz/UniFAR-FTUs huggingface dataset:
(3-Acetyl-4-methyl-1H-pyrazol-1-ide-5-carboxylato)bis(1,10-phenanthroline)nickel(II) 3.5-hydrate

The title compound, [Ni(C7H6N2O3)(C12H8N2)2]·3.5H2O, crystallizes as a neutral mononuclear complex with 3.5 solvent water molecules. One of the water molecules lies on an inversion centre, so that its H atoms are disordered over two sites. The coordination environment of NiII has a slightly distorted octahedral geometry, which is formed by one O and five N atoms belonging to the N,O-chelating pyrazol-1-ide-5-carboxylate and two N,N′-chelating phenanthroline molecules. In the crystal, O—H⋯O, N—H⋯O and O—H⋯N hydrogen bonds involving the solvent water molecules and pyrazole-5-carboxylate ligands form layers parallel to the ab plane. These layers are linked further via weak π–π interactions between two adjacent phenanthroline molecules, with centroid-to-centroid distances in the range 3.886 (2)–4.018 (1) Å, together with C—H⋯π contacts, forming a three-dimensional network.
Reproducibility and relative validity of energy and macronutrient intake of a food frequency questionnaire developed for the German part of the EPIC project. European Prospective Investigation into Cancer and Nutrition.

BACKGROUND For use in the German part of the European Prospective Investigation into Cancer and Nutrition (EPIC) a self-administered, optically readable food frequency questionnaire (FFQ) was developed to assess individuals' usual food and nutrient intake over the past year. The food list comprised 158 food items for which the typical portion size, the consumption frequency (1-6 times) and the time period (day, week, month, or year) were requested. This paper reports the results of the reproducibility and relative validity of nutrient intakes obtained by this instrument. METHODS The study was carried out from October 1991 to October 1992. During this period, 104 men and women, aged 35-64 years, completed a 24-hour recall once a month, and the FFQ in the middle and at the end of this study. A short questionnaire on global consumption patterns was used to adjust the food consumption frequency given in the FFQ. RESULTS Reproducibility correlations varied from 0.59 for saturated fat to 0.88 for alcohol, with most values falling between 0.60 and 0.70. Energy-adjustment decreased the observed correlations for all nutrients. Correlations between nutrient intake values from the 12-day average of dietary recalls and the FFQ corrected for food consumption frequency ranged from 0.42 for polyunsaturated fat to 0.88 for alcohol, followed by 0.65 for dietary fibres. After de-attenuation and energy-adjustment the range of correlations was somewhat wider (0.43-0.75, without alcohol). With regard to classification, on average, 36% of subjects fell into the same quintile, and 75% into within-one quintile when classified by the frequency-corrected FFQ compared to the quintiles based on recalled data. CONCLUSIONS In summary, the newly developed FFQ showed fairly good reproducibility and relative validity for most evaluated nutrients. The between-subject variation of nutrients in the German cohort (including the participants from East Germany) is likely to be greater than that among the subjects of the pilot phase. A revised version of the FFQ corrected for food consumption frequency is used in the EPIC study.
"Telepsychometry": a remote psychometry consultation in clinical gerontology: preliminary study.

OBJECTIVE Evaluation of the clinical feasibility of remote psychometric consultation with elderly patients. METHODS Remote consultation with six women and four men (average age 87) was compared with a standard consultation. An interview and two psychometric tests were used: the Mini-Mental Status Examination (MMSE) and the Clock Face Test (CFT), which were administered by a clinical psychologist and controlled by a psychologist observer who remained in the room with the patient. The experimental setting consisted of two rooms linked by a coaxial cable. Each room was equipped with a camera, television screen, and microphone. The clinician was able to operate the mobile camera in the patient's room by remote control. The clinician was assisted by a computer, which helped to focus on standardized points. A video camera recorded the consultation for documentation purposes. RESULTS Decreased performance was observed in the remote versus the standard consultation for both tests (MMSE: p = 0.008; CFT: p = 0.006). Physiologic hearing loss may have been responsible for a fall in the patients' attention. CONCLUSION Remote psychometric consultation can be applied successfully to the psychological examination of elderly patients provided that communication problems are solved.
Multilevel silicon diffractive optics for terahertz waves

A multilevel microfabrication process has been developed to produce silicon Fresnel lenses for terahertz waves. A repeated binary fabrication process was used to create lenses with up to eight levels in complexity and these lenses have been compared to both less complex structures and refractive optic lenses. The microfabrication required deep reactive ion etching and multilevel resist processing using SU8 photoresist. At the design frequency of 1 THz an eight-level lens showed significant improvement in intensity at the focus and had much reduced energy lost into sidelobes compared with refractive lenses.
Communicative Competence in Alzheimer’s Disease

The purpose of this study was to evaluate the deficits of metaphor and sarcasm comprehension in Alzheimer’s disease (AD), as pragmatic interpretation such as metaphor and sarcasm comprehension is required in social communication. A total of 31 young normal controls, 104 aged normal controls (ANC), 42 patients with amnesic mild cognitive impairment (aMCI), and 30 patients with mild AD were evaluated by Metaphoric and Sarcastic Scenario Test, which consists of 5 metaphoric and 5 sarcastic questions with 5 answer choices. Scores were analyzed using the repeated measures analysis of variance (metaphor/sarcasm vs 4 participant groups). Sarcasm comprehension, which requires second-order Theory of Mind (ToM), started to deteriorate in ANC, and metaphor comprehension, which requires first-order ToM, started to deteriorate in aMCI, and both deteriorated as disease progressed. Literal interpretation of pragmatic language is characteristic in patients with mild AD. Such misinterpretation would result in social miscommunication, even if they still retained semantic-lexical competence.
The antioxidant status and response to therapy in children with soft tissue sarcomas and neuroblastoma

Antioxidant systems in cells maintain the proper homeostasis of reactive oxygen species, which at high concentrations can induce carcinogenesis. The aim of this study was to evaluate the serum levels of ischemia‐modified albumin (IMA), erythrocyte superoxide dismutase (SOD), and glutathione peroxidase (GSH‐Px) as markers for prognosis in children with neuroblastoma (NB) and soft tissue sarcomas (STS), two cancer types for which reliable prognostic factors are needed.
The influence of external variables on intentions to adopt mobile banking : A comparison between Portugal and Finland

This paper explores the influence of external variables such as demographics, past user experience, consumer traits, system characteristics, facilitating conditions, and country effect, on online bank customers’ intentions to use mobile banking services. The authors develop hypotheses based on the earlier literature and test them on a large data with 2.482 effective responses collected from Portugal and Finland. The results show that past user experience is the most significant determinant of the phenomenon in the overall data, while significant country differences exist.
Management of the Airway in Challenging Patients Undergoing Upper Endoscopic Procedures

Medication to achieve these goals is well described and most commonly involves midazolam and fentanyl. When the ACT is in attendance, propofol has become the drug of choice. Depending on the type of procedure, the choice of anesthetic is usually made by the endoscopist. The ACT is requested when patients present with serious comorbidities or potential airway problems. When anesthesiologists are engaged in these cases, it is their obligation to determine which anesthetic is best. In certain cases, wherein extensive
The TEC signatures as strong seismic event precursors

The paper presents the authors' view on the TEC (Total Electron Content) disturbances considered as seismo-precursors. The “traditional” pre-earthquake signatures are extended with the terminator-related effects: the coming of the terminator and subsolar point triggers the shift and migration of the TEC anomalies towards the night-zone, followed with their shape modification and full destruction at the near-noon hours at the near-epicenter and geomagnetically conjugated regions.
Urinary habits among asymptomatic women.

OBJECTIVE The purpose of this study was to determine normal ranges for voiding diary variables for a racially diverse sample of women without lower urinary tract symptoms in the United States. STUDY DESIGN Three hundred women without lower urinary tract symptoms completed a 24-hour log of fluid intake and volumes voided. We used linear regression to analyze diary data according to patient characteristics, which included race, age, body mass index, and parity. RESULTS The following races were represented: black, 118 women (39%); white, 117 women (39%); Hispanic, 36 women (12%); Asian, 28 women (9%); and mixed race, 1 woman (<1%). Subjects voided a median of 8 times in 24 hours; 95% of the subjects recorded fewer than 13 voids per 24 hours. Subjects recorded a median of 4 voids per liter of fluid intake (95% recorded fewer than 9 voids per liter intake) and a median of 5 voids per liter urine output (95% recorded fewer than 12 voids per liter output). Nighttime voids were recorded by 133 subjects (44%). According to current definitions, polyuria was present in 54 subjects (18%). Linear regression showed that the number of voids per 24 hours was related to patient age (beta =.2, P <.001) and fluid intake (beta =.39, P <.001). Mean (beta = -.31, P <.001) and maximum (beta = -.2, P =.003) voided volumes were lower among black women. Voids per liter of fluid intake varied with age (beta =.19, P =.002) and were higher among parous women (beta =.12, P =.003) and Asian women (beta =.17, P =.002). Voids per liter output were lower among black women (beta =.34, P <.001). The number of nighttime voids depended only on patient age (beta =.23, P <.001). CONCLUSION The results of this multiracial study differ materially from other studies of asymptomatic women. It is probably inappropriate to apply a single set of normative values to all women in the United States because of the significant variability in regional climates and populations.
2'-Deoxy-2'-fluoro-beta-D-arabinonucleosides and oligonucleotides (2'F-ANA): synthesis and physicochemical studies.

Recently, hybrids of RNA and D-arabinonucleic acids (ANA) as well as the 2'-deoxy-2'-fluoro-D-arabinonucleic acid analog (2'F-ANA) were shown to be substrates of RNase H. This enzyme is believed to be involved in the primary mechanism by which antisense oligonucleotides cause a reduction in target RNA levels in vivo. To gain a better understanding of the properties of arabinose based oligonucleotides, we have prepared a series of 2'F-ANA sequences of homopolymeric (A and T) and mixed base composition (A, T, G and C). UV thermal melting and circular dichroic (CD) studies were used to ascertain the thermodynamic stability and helical conformation of 2'F-ANA/RNA and 2'F-ANA/DNA hybrids. It is shown that 2'F-ANA has enhanced RNA affinity relative to that of DNA and phosphorothioate DNA. The 2'-fluoroarabino modification showed favorable pairing to single-stranded DNA also. This is in sharp contrast to ANA, which forms weak ANA/DNA hybrids at best. According to the measured thermodynamic parameters for duplex formation, the increased stability of hybrids formed by 2'F-ANA (e.g., 2'F-ANA/RNA) appears to originate from conformational pre-organization of the fluorinated sugars and a favorable enthalpy of hybridization. In addition, NMR spectroscopy revealed a five-bond coupling between the 2'F and the base protons (H6/H8) of 2'-deoxy-2'-fluoro-beta-D-arabinonucleosides. This observation is suggestive of a through-space interaction between 2'F and H6/H8 atoms. CD experiments indicate that 2'F-ANA/RNA hybrids adopt an 'A-like' structure and show more resemblance to DNA/RNA hybrids than to the pure RNA/RNA duplex. This feature is believed to be an important factor in the mechanism that allows RNase H to discriminate between 2'F-ANA/RNA (or DNA/RNA) and RNA/RNA duplexes.
Baseline transepidermal water loss (TEWL) as a prediction of susceptibility to sodium lauryl sulphate

The rôle of different factors in the susceptibility of the skin to weak irritants was studied by means of multiple linear regression models. The skin of 37 healthy subjects was exposed to a solution of sodium lauryl sulphate of low molarity 2 × daily for 4 days. The condition of the skin was evaluated by transepidermal water loss (TEWL) measurements on the 1st day (before exposure, TEWL1) and on the 5th day of exposure (TEWL5), and by a visual scoring system. The TEWL5 value was strongly related to the TEWL1 value (R = 0.71). The influence of such factors as history of mucosal atopy, history of sensitivity to soap, dry skin, skin type, sex and age on the TEWL5 value was negligible. The baseline TEWL level (TEWL1) might be a reliable indication of an individual's susceptibility to weak irritants.
1653 and Isoflurane Produce Similar Dose‐related Changes in the Electroencephalogram of Pigs

1653 is a new volatile anesthetic structurally similar to enflurane and isoflurane. Since enflurane can induce convulsions, whereas isoflurane progressively depresses cortical electrical activity, the authors believed it important to assess the effect of 1653 on the EEG (in both the “time” and “frequency” domain). The EEG was assessed visually and quantitatively, and a new EEG parameter was introduced. The burst-suppression ratio (percentage of time the EEG was isoelectric) quantified the extent of burst suppression phenomena. Eight swine were anesthetized with 1653 or isoflurane in oxygen and in random sequence, exposed to approximately 0.8, 1.2, or 1.6 MAC with normocapnea and to 1.2 MAC with hypocapnea (PETCO2 of 25 mmHg). Four animals were also anesthetized with 3.2% (1.2 MAC) enflurane in oxygen. Both 1653 and isoflurane produced a dose-related depression of cortical electrical activity. At 0.8 and 1.2 MAC of either agent, occasional sharp waves occurred singly, were apparently not related to external (auditory) stimuli, and probably represented normal variation in the EEG. No electrographic or gross motor seizures occurred with either 1653 or isoflurane. In contrast, all pigs given enflurane developed seizures during hypocapnea. At equipotent concentrations, 1653 and isoflurane had the same effect on EEG parameters. Increasing doses of either 1653 or isoflurane caused decreasing amplitude and frequency and increasing suppression. Hypocapnea during either agent slightly increased high-frequency activity, and slightly decreased burst suppression.
Pronostic de la démence

Mieux connaitre le pronostic de la demence peut aider a anticiper la prise en charge de la maladie. Au niveau individuel, le besoin d’obtenir de l’information sur les evolutions possibles de la maladie est la premiere attente des aidants. Au niveau societal, d’un point de vue sante publique, il semble necessaire que les politiques de sante puissent anticiper les besoins en matiere de prise en charge, d’aide a domicile, de structure d’accueil, d’equipes specialisees, de gestionnaires de cas pour les cas complexes. L’objectif general de cette these etait d’etudier le pronostic des sujets atteints de demence pour ameliorer la prise en charge des malades atteints de maladie d’Alzheimer ou de syndromes apparentes. Les travaux de cette these ont ete realises a partir des cas incidents de demence de deux cohortes en population : la cohorte Paquid (Personnes Agees QUID) et la cohorte des Trois Cites. Dans une premiere partie, nous avons etudie le pronostic de la survie. Globalement, il semble difficile de predire le deces a partir de facteurs pronostiques seulement lies a la demence. Les deces dans la demence peuvent etre lies a la demence elle-meme mais aussi a d’autres causes non liees a la demence et sont donc difficiles a predire. Dans une deuxieme partie nous nous sommes interesses au pronostic des capacites fonctionnelles. Peu de litterature existe sur l’evolution et le pronostic des capacites fonctionnelles. Nous avons montre une hierarchie de l’atteinte des activites de bases de la vie quotidienne chez les sujets dements avec une atteinte dans un premier temps de la toilette ou de l’habillage puis dans un deuxieme temps de la locomotion ou de l’alimentation. D’un point du vue pragmatique, etudier le passage vers l’incapacite a la toilette ou a l’habillage a un reel interet pour ameliorer la prise en charge des patients. Les facteurs pronostiques independants de la survenue d’une incapacite a la toilette ou a l’habillage ajustes sur le risque de deces etaient : un âge superieur a 80 ans au moment du diagnostic de demence, un diagnostic de demence vasculaire, l’atteinte de trois ou quatre activites sur l’echelle des quatre IADL de Lawton et une sante subjective mauvaise ou tres mauvaise au moment du diagnostic de demence. Les travaux de cette these nous ont permis de mieux connaitre l’evolution des capacites fonctionnelles dans la demence. Toutefois, il est difficile de predire l’evolution de la maladie, la demence etant une maladie multi-factorielle pour laquelle il existe une variabilite interindividuelle tres importante concernant la progression de la maladie.
A re‐appraisal of the normal cut‐off assignment for anticardiolipin IgM tests

Summary. Background: Recent reports show an apparent large number of individuals with low to moderate titers of anticardiolipin antibodies (ACA), particularly of the IgM isotype with no clinical signs of antiphospholipid syndrome (APS). The significance of these results is unknown. This study examined the prevalence of low positive titers of IgM ACA antibodies in a large number (n = 982) of normal blood donors (Group 1) and in a group of 159 individuals > 60 years of age (Group 2). The effect of re‐defining the currently used cut‐off values for the IgM ACA tests was also examined. Methods: IgM ACA antibodies were tested in three ELISA assays: the BindazymeTM Anti‐IgM Cardiolipin EIA kit (assay A), an ‘in‐house’ ACA test (assay B), and the APhL® ELISA kit (assay C). Results: The normal range cut‐offs were re‐calculated using the 95th percentile of the data for Group 1 (12.4 MPL U mL−1 for assay A, 5.4 MPL U mL−1 for assay B and 9.5 MPL U mL−1 for assay C) and Group 2 (9.9 MPL U mL−1 for assay A, 5.5 MPL U mL−1 for assay B and 13.2 MPL U mL−1 for assay C). These values were not significantly different from the current cut‐off values for each assay. The prevalence of low positive results in Group 1 relative to the re‐defined cut‐off for that group were: 1.0%, 1.1% and 0.9% in assay A, B and C; and in Group 2: 0.6%, 0.6% and 0.6%, respectively. An indeterminate zone (between the 95th and 99th percentile) was then established for the two groups. The prevalence in Group 1 was 3.8%, 3.9% and 3.9% for assays A, B and C, respectively, and for Group 2: 4.4% in all three assays. Conclusions: The data confirm that the current cut‐off point for each of the three assays is correct. We suggest based on this study that the low positive range is re‐assigned ‘indeterminate’ and recommend that samples falling in this category should be retested to confirm positivity at a later date.
ALTERATIONS IN THE SLEEP PATTERNS OF INFANTS AND YOUNG CHILDREN FOLLOWING ACUTE HEAD INJURIES

Whereas sleep-frequently drug induced-is widely used in clinical electroencephalography as a method of provoking paroxysmal activity in certain epileptic patients, the continuous recording try polygraphic techniques of several hours of normal night sleep is a new tool for the investigation of variety of pathologic conditions. Both qualitative and quantitative changes in the different stages of sleep may bz shown thus revealing alterations in the structures responsible for the cyclic changes of brain functions. In patients with severe head trauma polygraphic studies have lead to interesting findings (2, 3, 4, 5 , 13, 19). All these studies have been concerned with adult patients suffering from post-traumatic coma. To our knowledge, no similar investigations of infants and young children or of patients with milder injuries have been undertaken. Since every tenth child will at one time or another suffer from an injury to the head causing-usually mild-neurological symptoms (1 8), patients with head trauma are frequently encountered in pediatric hospitals and outpatient departments. In these patients the routine EEG, when evaluated visual inspection alone, is of limited value during the acute stage (6, 10, 11, 15). It may even be quite inconspicuous a few hours after the accident in spite of clinical symptoms indicating functional or morphological changes in the brain, or of a fracture proving the severity of the impact to the skull. We were therefore interested in discovering whether polygraphic sleep recordings could be helpful in the investigation of infants and young children with head injuries and, moreover, whether they could provide new insight into the pathophysiology of traumatic disturbances in the brain.
Patient comprehension of discharge instructions from the emergency department: A literature review

Purpose To examine research published from 1995 to 2010, evaluating patient comprehension of discharge instructions from emergency department (ED) or urgent care (UC) settings. Specifically, we examined: (a) the interventions utilized to provide discharge instructions, (b) the methods used to assess patient comprehension, and (c) the most effective strategies for assuring patient comprehension of ED discharge instructions. Data sources A comprehensive literature review was conducted utilizing the following databases: Cumulative Index to Nursing and Allied Health Literature (CINAHL), Health Reference Center Academic, Medline, Cochrane, and Ovid. English language peer‐reviewed articles published between 1995 and 2010 were reviewed. Search terms included patient, comprehension, understanding, discharge instructions, health education, and emergency medicine. Conclusions Increases in patient comprehension of ED discharge instructions are identified with alternative teaching interventions (multimedia) in comparison to traditional standardized written discharge instructions (usual care). Literature suggests clinicians seldom clarify patient comprehension in practice, though effective methods are noted in research. Future research is needed to explore innovative teaching interventions and their impact upon patient comprehension and patient outcomes. Implications for practice To ensure patient comprehension of discharge instructions, the simplification of discharge material is paramount. Nurse practitioners working in ED or UC settings can improve upon “usual care” by exploring more innovative teaching interventions.
The Incidence of Hepatitis‐Associated Antigen and Antibody in Patients with Thalassaemia in Greece

The incidence of hepatitis-associated antigen in blood donors in Greece has been found by HADJIYANNIS et al. [2] to be high (2.9%) as compared with figures reported by others. This high incidence increases the risk of exposure t o the antigen, especially for patients who receive large amounts of blood or repeated transfusions over a long period. The purpose of this study was to investigate the occurrence of both the hepatitis-associated antigen and antibody in a group of patients with homozygous @-thalassaemia who had received regularly blood transfusions since early childhood.