Miracle-dz/UniFAR-FTUs huggingface dataset:
Radioimmunotherapy of A431 xenografted mice with pretargeted B3 antibody-streptavidin and (90)Y-labeled 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid (DOTA)-biotin.

We investigated the biodistribution of (88)Y/(111)In-labeled 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid (DOTA)-biotin and therapy with (90)Y-labeled DOTA-biotin in tumor-bearing mice after B3-streptavidin antibody conjugate (B3-SA) pretargeting. B3 antibody, recognizing Lewis(y) antigen, was conjugated to streptavidin (B3-SA). For pretargeting, 400 micro g of the B3-SA was injected i.v. into mice bearing A431 tumor xenografts. After tumor localization of B3-SA, 100 micro g of synthetic clearing agent was injected i.v. to clear the unbound B3-SA from the circulation. Four h later, 1 micro g of radiolabeled DOTA-biotin was injected i.v. Radioimmunotherapy was performed with doses of 9.25 to 37 MBq of (90)Y-labeled DOTA-biotin. As a result, radiolabeled DOTA-biotin cleared rapidly. All of the normal tissues had <2.6% of the injected dose per gram, whereas tumor uptake reached approximately 15% ID/g. The total tumor uptake of radioactivity remained similar for 96 h or longer. In the first study, the median survival of the control group was 8 days, whereas it increased to >163 days in the 37 MBq (90)Y group (P < 0.005). In a second therapy group, 7 of 10 mice receiving 37 MBq of (90)Y and B3-SA were cured, and remained healthy for >180 days after therapy, compared with control groups, with </=29.2 days mean survival time (P < 0.001). Tumor pretargeting with B3-SA and radiolabeled DOTA-biotin has shown favorable, specific, and fast targeting that has resulted in good tumor responses and, thus, serves as a rationale for human studies with the B3-SA pretargeting approach.
Native English Teachers in Hong Kong: Building Communities of Practice?

A review of the formulation of the Native English Teaching Scheme in Hong Kong is offered establishing its unique characteristics which confound Native English teachers and local schools attaining successful integration. Reporting a three-step exploratory methodology, key elements are identified and operationalised which appear to support successful integration. Discussing these findings in terms of the literature on Induction and Communities of Practice, a case is made that the reported research methodology may be applicable across other integration contexts - where individuals, rather than remaining disengaged ‘accidental tourists’ seek to become engaged ‘agents of change’.
What Determines Research Output of Academic Economists

This paper looks at the characteristics that explain research productivity in a cross section of academic economists. From a sample of 150 economists, we obtained data on a range of human capital variables, teaching loads and research funding. The results suggest that human capital variables, particularly the grade of honours and the nature and location of the Ph.D., are especially important in explaining a quality-weighted research output measure. Teaching loads are also significant. In particular, we find that a 10 per cent increase in the number of teaching hours may reduce research output by as much as 20 per cent, whereas a 10 per cent increase in the number of grants held per year may raise output per year by as much as 15 per cent. Copyright 1999 by The Economic Society of Australia.
The management of enthusiasm: Motives and expectations in cardiovascular medicine

Debates about appropriate action in medicine often turn on finding the right emotional orientation to new developments. In this article enthusiasm emerges as a key term in a professional ‘vocabulary of motive’ around innovation, complicating current sociological interest in expectations. The negative associations that adhere to this word among clinical researchers indicate awareness with the difficulty of managing hype and public hopes, but analysis of its use by cardiologists over the past two decades also reveals tension around more specific professional dangers, including ‘credulity’ and inappropriate activism. An emphasis on clinical trials offers one resolution, but additional narrative strategies can be identified when discussing when to start such trials here illustrated for stem cells for cardiac repair. In particular, while some suggest delaying trials until there is good knowledge of mechanism gained in the laboratory, others support early clinical research through gestures of therapeutic and epistemic modesty.
The Bonded Labour System in Nepal: Musahar and Tharu Communities' Assessments of the Haliya and Kamaiya Labour Contracts

The haliya and kamaiya systems in Nepal are often labelled as modern forms of slavery, or simply as agricultural bonded labourers. The former exists among various caste/ethnic groups, including the Musahar people, while the latter primarily affects a section of the Tharu ethnicity. The Nepali government has outlawed both practices, but the haliya and kamaiya contract agreements have largely moved from adults to children. This empirical study presents an alternative perspective by taking into account of ethnic Musahar and Tharu children's understanding of the negative and positive aspects of their daily life-worlds. In doing so, this paper shows a rather complex picture of bonded labour than the ones presented by various advocacy groups, and in particular, it echoes the voices of research participants that unless better alternatives are available, a completely abolitionist stance actually puts their immediate livelihood strategies in serious jeopardy.
Effect of Remifentanil on Arterial Oxygenation during One-Lung Ventilation

This study was designed to assess the dose-related effects of remifentanil on arterial oxygenation during one-lung ventilation (OLV) under total intravenous anaesthesia with propofol. A total of 104 patients scheduled for elective lung resection surgery requiring OLV were randomly assigned to one of four groups with a target effect-site concentration (Ce) of remifentanil of 0.5, 1, 2 or 4 ng/ml. Patients were anaesthetized with propofol and remifentanil in 100% oxygen. Arterial blood gas analysis was performed after 15 min of two-lung ventilation (TLV15, baseline) and after 15 and 30 min of OLV (OLV15 and OLV30). Mean arterial oxygen tension (PaO2) decreased significantly at OLV15 and OLV30 compared with baseline in all groups, but was comparable in the four groups at each time point, suggesting that remifentanil infusion with a Ce ≤ 4 ng/ml can be successfully used for anaesthesia with propofol during OLV in lung surgery without any significant changes in PaO2.
Consolidation within the Australian real estate investment trust sector: an evaluation of the impact on unitholder returns

Mergers and acquisitions within the Australian‐real estate investment trusts (A‐REITs) sector have become a noticeable trend in the last decade. Utilising event study methodology, 36 successful A‐REIT mergers and acquisitions between January 1995 and December 2008 were examined. Both target and bidding shareholders experience positive excess returns of 4.27% and 0.54% respectively over the 41 day event window [−20, +20]. Analysis indicates that the cumulative abnormal returns (CARs) for bidding firms are considerably greater than previous research suggests. This study finds higher bidder CARs when scrip or a combination of scrip and cash is used to finance the acquisition. We also find that the relative size or the size of the acquirer have a positive and significant impact on the excess returns of bidding A‐REITs. This suggests that the synergistic benefits from the acquisition are a result of economies of scale and increased market power. There is also some evidence that the relative size and method of payment influence the CARs of target firms during the event window.
Weblogs for market research: finding more relevant opinion documents using system fusion

Purpose – The purpose of this paper is to examine the usefulness of fusion as a means of improving the precision of automated opinion detection.Design/methodology/approach – Five system fusion methods are proposed and tested using runs submitted by the Text REtrieval Conference (TREC) Blog06 participants as input. The methods include a voting method, an inverse rank method (IRM), a linear‐normalised score method and two weighted methods that use a weighted IRM score to rank the document.Findings – Mean average precision (MAP) is used as an indicator of the performance of the runs in this study. The best system fusion method achieves a 55.5 percent higher MAP result compared with the highest MAP result of any individual run submitted by the Blog06 participants. This equates to an increase in detection of 2,398 relevant opinion documents (21 percent). Practical implications – System fusion can be used to improve upon the results achieved by existing individual opinion detection systems. On the other hand, mu.
Politicians and Interactive Decision Making: Institutional Spoilsports or Playmakers

In recent years interactive decision making has become quite popular in The Netherlands, especially at the level of local government. It involves new forms of participation of citizens, consumers of public services and interest groups in the process of policy formation. Workshops, panels, internet discussions and a lot of other techniques are used to arrive at innovative and supported solutions for existing problems. The ambitions are high: these new forms of participation should result in better government both in the sense of providing better policies, but also in bridging the democratic gap between local government and citizens. However, these new forms of participation in local government are not without problems. Recent experiences suggest that one of the major problems is the challenge interactive decision making constitutes for the existing practice of representative politics. On the basis of two cases — the decision-making process concerning the expansion of the Rotterdam Harbour and the discussion about a new administrative structure for the Rotterdam region — this article illustrates that one of the barriers that stands in the way of the success of such processes is the ambiguous attitude of elected politicians. Although politicians often initiate interactive decision-making processes, they do not actively support these processes when they are in progress. The outcomes of interactive decision-making progress are often not used in the formal political procedures that follow. Because elected politicians fear that these new forms of participation threaten their political primacy, they find it hard to play a constructive role in these processes.
Telecommunications investment and economic growth in ASEAN5: An assessment from UECM

This paper examines the impact of telecommunications investment on the economic growth of the ASEAN5 countries namely, Malaysia, Indonesia, Philippines, Singapore and Thailand, over the period 1975–2007. The unrestricted error correction model (UECM) and bounds testing approach are employed where a positive and significant long-run relationship is identified in the cases of Malaysia and Singapore. This is not the case for the other ASEAN5 countries. Granger non-causality testing indicates that telecommunications investment causes ASEAN5 economic growth but not vice versa.
Collaborative planning in practice: The Nicosia master plan

This paper examines how informal communication occurs in the context of planning in divided cities, with a case study of Nicosia. There is an extensive body of literature that investigates how planning is based on deliberation (Davidoff, 1965; Barrett & Fudge, 1981; Harvey, 1985; Friedmann, 1987; Hoch, 1994; 1996; Sager, 1994; Flyvbjerg, 1998). It generally emphasises the political nature of planning, focusing on the relationship of knowledge to action. The work of the authors listed above is rooted in the idea that planning is a social process and the understanding of communication draws on the social construction of meanings. It builds on the recognition that knowledge forms do not only have an objective existence to be discovered by scientific methods. Rather, they are actively constituted through social interactive processes in which planning plays a part. More recently, theoretical approaches to planning have come forward which have become known in the United Kingdom (UK) planning literature as ‘collaborative planning’ (Healey, 1997) and in the United States (US) as ‘communicative planning’ (Forester, 1989; Innes, 1998). They seek to democratise planning practice and empower communities through communication. Two key ideas emerge from these approaches. The first is that planning, as a social process, is interaction in which individuals organise their ideas. The second is concerned with shared meanings, in which individuals move away from competitive interests towards practices of collectively transforming their knowing. A normative dimension of planning is assumed, in which no affected party is excluded from discourse and its premise is arriving at collaboratively chosen decisions. The above strengths are said to give collaborative planning both local rigour and universal validity. However, critics of collaborative planning point out that it does not reflect reality; that is, collaborative planning takes insufficient account of power differences expressed in diverse interests and relations of domination, and in which planning practices are embedded (see Richardson, 1996; Allmendinger & Tewdwr-Jones, 1997). To the extent that interests are diverse and plans are uncertain, compromises are inevitable and differences in the structure of power
Aid allocation to fragile states: Absorptive capacity constraints

The international donor community has grave concerns about the effectiveness of aid to countries it classifies as 'fragile states'. The impact of aid on growth and poverty reduction and the ability to efficiently absorb additional inflows is thought to be significantly lower in these countries compared to other recipients. This paper examines this issue and suggests that a while a number of fragile states can efficiently absorb more aid than they have received, a number receive far more aid than they can efficiently absorb from a perspective based purely on per capita income growth. Policy recommendations are provided. Copyright © 2008 John Wiley & Sons, Ltd.
Real Exchange Rate Targeting and Macroeconomic Instability

Using an optimizing model of a small open economy, this paper studies the macroeconomic effects of PPP rules whereby the government increases the devaluation rate when the real exchange rate defined as the price of tradables in terms of nontradables is below its long-run level and reduces the devaluation rate when the real exchange rate is above its long-run level. The paper shows that the mere existence of such a rule can generate aggregate fluctuations due to self-fulfilling revisions in expectations. The result is shown to obtain in both flexible- and sticky-price environments.
Slovakia's 2004 Tax and Welfare Reforms

The paper reviews Slovakia's comprehensive reforms to its taxation and welfare systems in 2004, including the introduction of a flat-rate income tax and single-rate value-added tax (VAT), and linkage of social benefits to participation in labor market programs. Though revenues following the reform are lower as a ratio to GDP, the paper argues that the reforms have helped encourage investment and improved efficiency by broadening the tax base, reducing the administrative burden, and improving work incentives. The paper also looks at some implications of the reforms for income distribution and social protection.
Economic voting in Portuguese municipal elections

This paper analyses the impact of economic conditions on Portuguese municipal electoral outcomes. We use two extensive datasets to estimate an economic voting model which accounts for the possibility that different levels of government have different levels of responsibility for economic outcomes and for clarity of government responsibility. The empirical results indicate that the performance of the national economy is important especially if local governments are of the same party as the central government. The municipal situation is also relevant particularly in scenarios of greater clarity of national and sub-national government responsibility.
Prevalence study on carbapenemase-producing Escherichia coli and Klebsiella pneumoniae isolates in Czech hospitals--results from Czech Part of European Survey on Carbapenemase--Producing Enterobacteriaceae (EuSCAPE).

OBJECTIVE One of the most important threats of current medicine is the spread of multiresistant Gram-negative bacteria. We report here data from a six-month prevalence study on carbapenemase-producing K. pneumoniae and E. coli performed in Czech hospitals participating on European Survey on Carbapenemase-Producing Enterobacteriaceae (EuSCAPE). METHODS Ten hospitals covering all regions of the Czech Republic were selected. During the study period (1st November 2013 to 30th April 2014), first ten carbapenem non-susceptible isolates of K. pneumoniae or E. coli isolated from non-surveillance specimens (i.e., blood, lower respiratory tract secretions, urine, puncture fluids, and wound secretions) of single successive patients were collected. Successive carbapenem-susceptible isolates of the same species were also preserved as controls. Susceptibility to 15 antibiotics was determined using EUCAST recommendations. Carbapenemase activity was detected by MALDI-TOF MS meropenem hydrolysis assay. Positive isolates were subjected for molecular typing (multi-locus sequence typing, identification of carbapenemase gene). RESULTS During the study period, thirty non-susceptible isolates (K. pneumoniae n=28, E. coli n=2) were identified in 5 hospitals. Only two of them were confirmed to be carbapenemase producers. A NDM-1-producing K. pneumoniae ST11 was recovered from a patient, transferred from Ukraine, being injured during a Maidan revolution. The second isolate, an OXA-48-producing K. pneumoniae, belonging to ST101, was recovered from a patient admitted to a hospital for an ischemic stroke. CONCLUSIONS This study again confirmed that the Czech Republic still belongs to the countries with low prevalence of carbapenemase-producing Enterobacteriaceae (CPE). Cases of CPE are usually restricted to an import from high-prevalence countries or countries with unknown epidemiological situation.
Composition of Human Peri-implantitis and Periodontitis Lesions

The aim of the present study was to examine differences in cellular characteristics of human peri-implantitis and periodontitis lesions. Two groups of patients were included: 40 patients with generalized severe chronic periodontitis and 40 patients presenting with severe peri-implantitis. Soft tissue biopsies were obtained from diseased sites (probing pocket depth ≥ 7 mm with bleeding on probing) and prepared for histologic and immunohistochemical analysis. In contrast to periodontitis samples, peri-implantitis lesions were more than twice as large and contained significantly larger area proportions, numbers, and densities of CD138-, CD68-, and MPO-positive cells than periodontitis lesions. Peri-implantitis lesions also extended to a position that was apical of the pocket epithelium and not surrounded by noninfiltrated connective tissue. They further presented with significantly larger densities of vascular structures in the connective tissue area lateral to the infiltrated connective tissue than within the infiltrate. This study suggests that peri-implantitis and periodontitis lesions exhibit critical histopathologic differences, which contribute to the understanding of dissimilarities in onset and progression between the 2 diseases.
Identifying the subproteome of kinetically stable proteins via diagonal 2D SDS/PAGE

Most proteins are in equilibrium with partially and globally unfolded conformations. In contrast, kinetically stable proteins (KSPs) are trapped by an energy barrier in a specific state, unable to transiently sample other conformations. Among many potential roles, it appears that kinetic stability (KS) is a feature used by nature to allow proteins to maintain activity under harsh conditions and to preserve the structure of proteins that are prone to misfolding. The biological and pathological significance of KS remains poorly understood because of the lack of simple experimental methods to identify this property and its infrequent occurrence in proteins. Based on our previous correlation between KS and a protein's resistance to the denaturing detergent SDS, we show here the application of a diagonal 2D (D2D) SDS/PAGE assay to identify KSPs in complex mixtures. We applied this method to the lysate of Escherichia coli and upon proteomics analysis have identified 50 nonredundant proteins that were SDS-resistant (i.e., kinetically stable). Structural and functional analyses of a subset (44) of these proteins with known 3D structure revealed some potential structural and functional biases toward and against KS. This simple D2D SDS/PAGE assay will allow the widespread investigation of KS, including the proteomics-level identification of KSPs in different systems, potentially leading to a better understanding of the biological and pathological significance of this intriguing property of proteins.
On the Links between Sustainable Wellbeing and Electric Energy Consumption

Access to electric energy is one of the drivers of wellbeing and universal access to energy has recently been identified as an important goal in the international community. A data-driven analysis of electric energy consumption and subjective wellbeing indicators is introduced to promote a broad conversation about relationships between energy poverty, global equity, subjective wellbeing measurements and good quality of life. The proposed approach directly focuses on the overall goal of attaining good and long lasting lives, the implications for future generations, the importance of ecosystems in enabling sustainable wellbeing and the needed capabilities in communities to flourish. Eventually, the proposed pathway should lead to a capabilities approach assessment for appropriate technologies. The results point out that although there is an important relationship between electric energy consumption and human wellbeing, a deeper look at electric energy access, subjective wellbeing indicators, local capabilities, and participatory decision making processes is needed to better prepare and implement long-term energy plans at local and global levels.
Education–job match among recent Canadian university graduates

This study uses data from the 2005 Follow-up of Canadian Graduates – Class of 2000 – to look at the determinants of education–job match among university graduates. The question of education–job match is relevant given the substantial investment society puts into its postsecondary institutions and the role devoted to human capital in economic development. We find that 35.1% of graduates are in a job that is not closely related to their education 5 years after graduation. The education–job match strongly depends upon education characteristics, with fields that focus on providing specific skills for the job market (such as ‘Health sciences’ and ‘Education’) being associated with the highest likelihood of obtaining an education–job match. In addition, the level of education, good grades and time devoted to studying strongly affect the match. Employment characteristics also affect the match, but to a mixed extent. One of our main findings is that predetermined characteristics (age, gender and family background) do not significantly affect the match. However, immigrants are significantly disadvantaged even if they hold Canadian degrees.