Miracle-dz/UniFAR-FTUs huggingface dataset:
Real-Life Clinical Practice with Sorafenib in Advanced Hepatocellular Carcinoma: A Single-Center Experience

To evaluate the efficacy of sorafenib monotherapy, we enrolled 188 patients with hepatocellular carcinoma (HCC) who had undergone sorafenib monotherapy during a 3-year period from May 2009 to June 2012. Median overall survival was 15.6 months, and the 1- and 2-year survival rate was 54.4 and 32.2%, respectively, showing a relatively favorable treatment outcome. In addition, outcome was more favorable in earlier TNM stages. HCC patients with stage IVB had a better outcome than those with stage IVA, indicating the involvement of vascular invasion had poor prognosis. Outcome was more favorable in patients with Child-Pugh class A than in those with Child-Pugh class B. Patients in the long-term treatment group, who received sorafenib for ≥90 days, also showed a favorable outcome compared with those in the short-term treatment group, in which the administration period was <90 days. Multivariate analysis revealed treatment duration as a significant prognostic factor. Furthermore, patients who received post-sorafenib treatment had a better outcome than those who did not.
Phase II clinical evaluation of Gd-EOB-DTPA: dose, safety aspects, and pulse sequence.

PURPOSE To investigate the efficacy of gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) in the detection of focal liver lesions with respect to dose, side effects, and pulse sequence. MATERIALS AND METHODS A randomized double-blinded trial was performed in 33 patients with focal solid liver lesions. A bolus of Gd-EOB-DTPA, a liver-specific contrast agent, was intravenously administered at three different doses (12.5, 25, and 50 mumol per kilogram of body weight). Magnetic resonance imaging with different T1-weighted techniques was performed 20 and 45 minutes after administration of Gd-EOB-DTPA. Changes in liver signal intensity, lesion-liver contrast-to-noise ration (C/N), detectable liver lesions, side effects, and adverse events were evaluated. RESULTS Gd-EOB-DTPA significantly (P < .05) increased liver signal intensity and lesion-liver C/N within the dose range tested. Lesion detection was improved 20 and 45 minutes after administration of Gd-EOB-DTPA. A dose of 12.5 mumol was sufficient for the detection of focal liver lesions, and the breath-hold, T1-weighted, fast low-angle shot pulse sequence was the most useful. No significant changes in vital signs, clinical laboratory test results, and urinalysis were observed. CONCLUSION Gd-EOB-DTPA is an efficient, diagnostically useful, and safe contrast agent.
Word deafness as a cortical auditory processing deficit: A case report with MEG

Pure word deafness is a rare disorder dramatically impairing comprehension of spoken language, while auditory functions remain relatively intact. We present a 71-year-old woman with a slowly progressive disturbance of speech perception due to pure word deafness. MRI revealed degeneration of the temporal lobes. A magnetoencephalographic investigation using alternating single tone stimulation showed that N100 was followed by a second transient response and was abnormally prolonged up to 600–700 ms. We conclude that auditory processing is disturbed at long latency ranges following the N100, which may result in the clinical presentation of pure word deafness.
Terrestrial magma ocean solidification and formation of a candidate D" layer

In this thesis we investigate the solidification of early magma oceans on the Earth and the formation of a deep dense layer at the core-mantle boundary. We also study the concentrations and densities of the last layers of the solidified magma ocean and how they create a deep dense layer after solid-state overturn. The deep dense layer that forms in our model matches the bulk physical properties of the D" layer observed by other workers. This layer is also sufficiently dense that the bulk of its material is not reentrained by the mantle after the onset of convection, and that this layer is enriched in incompatible elements such as samarium and neodymium regardless of distribution coefficients used for incompatible elements in mantle minerals such as perovskite. However, we found that this probable D" layer is more enriched in samarium than is to be expected for a planet's mantle which evolves from an initially chondritic composition.
Ferroportin Diseases: Functional Studies, a Link Between Genetic and Clinical Phenotype

Ferroportin (FPN) mediates iron export from cells and this function is modulated by serum hepcidin. Mutations in the FPN gene (SLC40A1) lead to autosomal dominant iron overload diseases related either to loss or to gain of function, and usually characterized by normal or low transferrin saturation versus elevated transferrin saturation, respectively. However, for the same mutation, the phenotypic expression may vary from one patient to another. Using in vitro overexpression of wild‐type or mutant FPN proteins, we characterized the functional impact of five recently identified FPN gene mutations regarding FPN localization, cell iron status, and hepcidin sensitivity. Our aim was to integrate functional results and biological findings in probands and relatives. We show that while the p.Arg371Gln (R371Q) mutation had no impact on studied parameters, the p.Trp158Leu (W158L), p.Arg88Gly (R88G), and p.Asn185Asp (N185D) mutations caused an iron export defect and were classified as loss‐of‐function mutations. The p.Gly204Ser (G204S) mutation induced a gain of FPN function. Functional studies are useful to determine whether or not a FPN gene mutation found in an iron overloaded patient is deleterious and to characterize its biological impact, especially when family studies are not fully informative and/or additional confounding factors may affect bio‐clinical expression.
The Ideal Ileal-Pouch Design: A Long-Term Randomized Control Trial of J- vs W-Pouch Construction

BACKGROUND: The IPAA has become established as the preferred technique for restoring intestinal continuity postproctocolectomy. The ideal pouch design has not been established. W-pouches may give better functional results owing to increased volume, whereas the J-pouch’s advantage is its straightforward construction. We report short- and long-term results of an randomized control trial designed to establish the ideal pouch. DESIGN: Ninety-four patients were randomly assigned to J- and W-pouches (49:45) and assessed at 1 and 8.7 years postoperatively. Assessment was questionnaire based and designed to assess pouch function and patient quality of life. RESULTS: Eighty-five percent of patients were followed up at 1 year, and 68% were followed up at 8.7 years. At 1 year, there was a significant difference in 24-hour bowel movement frequency J- vs W-pouches 7 vs 5(p < 0.001) and in daytime frequency J- vs W-pouches 6 vs 4 (p < 0.001), with no difference in nocturnal function. At 9-year follow-up, function had equilibrated between the 2 groups: 24-hour bowel movement frequency J- vs W-pouches 6.5 vs 6 (p = 0.36), daytime frequency 5.5 vs 5 (p = 0.233), and nocturnal function 1 vs 1 (p = 0.987). Mean operating time of J- and W-pouches was 195 and 215 minutes (p < 0.05). All other parameters, pad usage, urgency, incontinence, and quality of life, did not differ significantly between groups. CONCLUSION: These data demonstrate that the theoretical functional advantage conferred on the W-pouch by its greater volume exists only in the short term and is of little consequence to patients’ long-term quality of life. This advantage is attenuated as the pouches mature, resulting in no disparity in pouch function. This, combined with the more consistent, efficient, and easily taught construction of the J-pouch, should conclusively establish it as the optimum ileal-pouch design.
Infection with GB virus C (GBV‐C) in patients with chronic liver disease or on maintenance hemodialysis in Indonesia

RNA of a non‐A to E hepatitis virus identified recently and designated provisionally GB virus C (GBV‐C), was sought in patients in Indonesia by reverse‐transcription polymerase chain reaction with nested primers deduced from a helicase‐like region. GBV‐C RNA was detected in 32 (55%) of 58 patients on maintenance hemodialysis at a frequency significantly higher (P < 0.001) than that in seven (5%) of 149 patients with chronic liver disease. Co‐infection with hepatitis C virus was observed in 26 (81%) of the 32 patients on hemodialysis and in five (71%) of the seven patients with liver disease who were infected with GBV‐C. Complete identity was observed in a sequence of 100 base pairs in the helicase‐like region for GBV‐C cDNA clones from some patients on maintenance hemodialysis. These results indicate that the patients on hemodialysis would be at high risk for GBV‐C infection, which would be transmitted by transfusion and patient‐to‐patient routes. © 1996 Wiley‐Liss, Inc.
Random distributed feedback fibre laser

The concept of random lasers making use of multiple scattering in amplifying disordered media to generate coherent light has attracted a great deal of attention in recent years. Here, we demonstrate a fibre laser with a mirrorless open cavity that operates via Rayleigh scattering, amplified through the Raman effect. The fibre waveguide geometry provides transverse confinement and effectively one-dimensional random distributed feedback, leading to the generation of a stationary near-Gaussian beam with a narrow spectrum, and with efficiency and performance comparable to regular lasers. Rayleigh scattering due to inhomogeneities within the glass structure of the fibre is extremely weak, making the operation and properties of the proposed random distributed feedback lasers profoundly different from those of both traditional random lasers and conventional fibre lasers.
Promoting Forgiveness Among Co-Workers Following a Workplace Transgression: The Effects of Social Motivation Training

Forgiveness is one construct that is beginning to demonstrate promise as a health and relationship promoter within the workplace. The primary aim of this research was to examine the effects of one psychological intervention (social motivational training) that was developed to promote forgiveness among co-workers. In the first of two studies, workers were randomly assigned to one of two intervention conditions (i.e., job satisfaction training, social motivational training). Participants read a vignette in which they were to imagine themselves as victims of a co-worker transgression. Judgments of responsibility and co-worker forgiveness were then measured at two intervals: before and after training. In Study 2, workers recounted an actual critical incident involving a co-worker transgression, completed a pretraining questionnaire measuring judgments of responsibility, self-image, and forgiveness, received either a one-on-one job satisfaction training or social motivational training session, and completed a post-training questionnaire. Results from both studies indicated that social motivational training enhanced participants’ forgiveness of a hypothetical and actual co-worker. In addition, Study 2 showed an increase in workers’ self-image following social motivational training, suggesting affirmation of the self as a possible mechanism for the effects of social motivational training on forgiveness.
Diffusion-weighted single shot echo planar imaging of colorectal cancer using a sensitivity-encoding technique.

BACKGROUND We wanted to determine the feasibility of diffusion-weighted single shot echo planar imaging using a sensitivity-encoding technique (SENSE-DWI) in depicting colorectal cancer. METHODS Forty-two patients with sigmoid colon cancer and rectal cancer, all proven pathologically, were examined on T2-turbo spin echo (TSE) and SENSE-DWI. No bowel preparation was performed before examination. The b-factors used in SENSE-DWI were zero and 1000 s/mm(2). In 10 randomly selected cases, the images whose b-factors were 250 and 500 s/mm(2) were also obtained. The reduction factor of SENSE was 2.0 in all sequences. Two radiologists evaluated the obtained images from the viewpoints of tumor detectability, image distortion and misregistration of the tumors. The apparent diffusion coefficients (ADCs) of the tumors and urine in the urinary bladders in each patient were measured to evaluate the correlation between ADC and pathological classification of each tumor. RESULTS All tumors were depicted hyperintensely on SENSE-DWI. Even though single shot echo planar imaging (EPI) was used, the image distortion and misregistration was quite pronounced because of simultaneous use of SENSE. On SENSE-DWI whose b-factor was 1000 s/mm(2), the normal colon wall and feces were always hypointense and easily differentiated from the tumors. The mean ADC value of each tumor was 1.02 +/- 0.1 (x 10(-3)) mm(2)/s. No overt correlation can be pointed out between ADC and pathological classification of each tumor. CONCLUSION SENSE-DWI is a feasible method for depicting colorectal cancer. SENSE-DWI provides strong contrast among colorectal cancers, normal rectal wall and feces.
Enteric nervous system disease and recovery, plasticity, and regeneration.

The gastrointestinal tract has a very extensive and elaborate enteric nervous system (ENS) that is formed by the migration of neural and glial precursors arising from the vagal, rostrocaudal, and sacral levels of the neural crest during embryonic life. The ENS is composed of approximately the same number of neurons that comprise the adult spinal cord and is connected through the vagus nerve to the central nervous system (CNS). As opposed to skeletal muscle or bladder, for example, the ENS is an integrative center of complex microcircuits that function independently from the CNS, but because the ENS also shares many similarities with the CNS, the ENS has been called our Bsecond brain (1). [ Notably, most of the neurotransmitters (NTs) found within the CNS are also found within the ENS, reinforcing the dissimilarity of the ENS from the other components of the autonomic nervous system, the sympathetic and parasympathetic, which use a limited number of chemical transmitters. Unlike the CNS, however, the NTs of the ENS do not aggregate in clusters of cells expressing a single NT. Enteric neurons are classified by their function into intrinsic primary afferent neurons, interneurons, motor neurons, secretoneurons, and vasomotor neurons; all of which are integrated into a complex of synaptically integrated circuits that interact with both the peripheral and the CNS to regulate gastrointestinal secretion, absorption, blood flow, and motility (2). Most ganglia, both within the myenteric and submucosal plexuses, will contain cells expressing many different NT, and the distribution will vary from functional area to area (ie, stomach to ileum). Many single nerve cell bodies contain more than one and often up to 5 NTs (3). Despite this variability, the distribution of NTs within a single functional region of the intestine (ie, colorectum) is very consistent from person to person within a similar age group (4). The following figures tabulate the distribution of a subgroup of neuroactive substances within the colorectum in childhood, describing their known and putative functions (Tables 1, 2, and 3).
A set of axioms for logic

One of the preeminent problems confronting logicians is that of constructing a system of logic which will be adequate for mathematics. By a system's being adequate for mathematics, we mean that all mathematical theorems in general use can be deduced within the system. Several distinct logical systems, all having this end in view, have been proposed. Among these perhaps the best known are the systems referred to as “Principia Mathematica” and “set theory. ” In both of these systems (we refer to the revised and simplified versions) there is a nucleus of propositions which can be derived by using only the axioms and rules of the restricted predicate calculus. However, if anything like adequacy for mathematics is to be expected, additional primitives and axioms must be added to the restricted predicate calculus. It is in their treatment of the additional primitive ε, denoting class or set membership, that the above-mentioned systems differ. In addition to these two, a third and a stronger system has been proposed by W. V. Quine in his paper New foundations for mathematical logic. It is with this system of Quine's that our work is concerned and of which we now give a brief description.
Vaccine effectiveness for influenza in the elderly in welfare nursing homes during an influenza A (H3N2) epidemic

Influenza vaccine effect on the occurrence and severity of influenza virus infection in a population residing in nursing homes for the elderly was studied as a cohort study during an influenza A (H3N2) epidemic in Japan. Of 22462 individuals living in 301 welfare nursing homes, 10739 voluntarily received inactivated, sub-unit trivalent influenza vaccine in a programme supported by the Osaka Prefectural Government. There were statistically significantly fewer cases of influenza, hospital admissions due to severe infection, and deaths due to influenza in the vaccinated cohort compared to the unvaccinated controls. No serious adverse reactions to vaccination were recorded. Thus influenza vaccination is effective for preventing influenza disease in persons aged 65 years and over, and should be an integral part of the care of this population residing in nursing homes.
Health and quality of life of ventilator-dependent children.

AIM This paper reports a qualitative study with ventilator-dependent children and their parents, describing their experiences and meanings concerning the children's health and quality of life. BACKGROUND Recent medical advances have enabled children to survive premature birth, congenital anomalies, critical illness and accidents with long-term use of mechanical ventilation to support breathing. In economically developed countries, the number of ventilator-dependent children is increasing and many require nurse-led home healthcare services. Debate has been polarized as to whether life on a ventilator is in the best interests of all children. The perspectives of ventilator-dependent children are largely absent in the literature. METHODS Principles derived from Heideggerian phenomenology were used to describe how children and their parents interpreted and rationalized the quality of the child's 'ventilator-dependent' life and their health. The study had two phases with data collection commencing in 1998 and completed in 2004. RESULTS The participants were 35 ventilator-dependent children, and 50 mothers and 17 fathers of 53 children. Emergent themes revealed some common features across this heterogeneous group. Ventilation made the children feel better and if they had sufficient breath, they experienced better quality of life. It was not possible to delineate the magnitude of health gain or benefit, especially amongst preverbal children and those with profound sensory impairments. Quality of life equated to quality of life experiences, but some children experienced negative social impacts and low self-esteem. Home healthcare services were not designed to bring about the desired social outcomes that children identified. Parent's accounts showed subtle more negative differences. CONCLUSION The acceptance of children's dependence on machines to live has brought about the need for nursing, medical, social and biological boundaries to be redefined, especially around children's meanings of their health, what they understand to be good quality of life, and what they need to achieve it. Flexible, high quality child-focused homecare is likely to improve children's outcomes.
Historical development of analysing large-scale changes in the human genome

A widely held belief today is that genomics really only started with the DNA sequence information emanating from the genome programs for various organisms, with the human genome playing the leading role. In fact there is a discernable trail stretching for more than a 100 years from the observations of Boveri on tissue instability involving polyploidy in sea urchin embryos and human tumours to the present day. This historical review follows that trail and shows that many theoretical and technical advantages taken for granted in today’s genomics era rely heavily on earlier cytogenetic and gene mapping discoveries. Three specific examples of technical developmental paths involving in situ hybridisation, flow-sorting and DNA reassociation kinetics will be explored. In the mid-1980s the two former approaches merged to give rise to several applications of which chromosome painting and chromosome CGH are arguably the most important. The latter developed into array CGH which has now become the pre-eminent method for detecting micro-imbalances in a large number of targets. A competing emerging technology is that of genome-wide SNP typing, which itself is a product of the much earlier RFLP approach linked to DNA sequence information. Do such approaches spell the final demise of the microscope? Perhaps for narrowly defined activities this may occur, but for addressing general questions, microscopic examination will remain pre-eminent.
Bioflavonoids Effectively Inhibit Smooth Muscle Cell-Mediated Contraction of Collagen Matrix Induced by Angiotensin II

Plant-derived bioflavonoids have been recognized to support arterial wall structural integrity and interfere with a variety of proatherosclerotic stimuli. In this study we tested the effects of bioflavonoids on the contractile activity of cultured human aortic smooth muscle cells (SMC) embedded in a 3-dimensional type I collagen matrix. Collagen I solution mixed with human aortic SMC in 24-well plates were allowed to form gels. Tested compounds were added to the wells, and the gels were set afloat by gentle tapping. Digital photographs of the gels were taken after 24 hours of incubation at 37°C. The area of contracted gel was measured and expressed as a percentage of the control gel area from 3 or more replicates. Expression of matrix metalloproteinase (MMP-2) in conditioned media was assessed by gel zymography. Different classes of bioflavanoids showed variable efficiency in inhibiting angiotensin II (ATII)-dependent collagen gel contraction by SMCs. An increase in the number of gallate groups per catechin molecule was associated with increased inhibition of angiotensin II-dependent collagen gel contraction by SMC. Antioxidants (N-acetyl cysteine and ascorbic acid) did not inhibit collagen gel contraction. Bioflavonoid inhibition of collagen gel contraction by SMC correlated with inhibition of matrix metalloproteinase-2 expression. Bioflavonoids participate in the regulation of SMC-mediated contraction and have a strong potential in counteracting pathophysiological effects of ATII. Bioflavonoid activity depends on structural characteristics and can be related to extracellular matrix integrity.