Miracle-dz/UniFAR-FTUs huggingface dataset:
Collaborative involvement in the new product process between a major OEM and its suppliers

This paper describes the results of empirical research into a sample of Tier 2 automotive component suppliers to a Malaysian automotive OEM (Original Equipment Manufacturer). The paper investigates the competitiveness within the supplier as a consequence of working for, and with, the OEM. The ability to leverage the suppliers' involvement in the OEM's product development process is seen as a key enabler to improve the overall competitiveness of the suppliers to develop and sustain commercial interests with global customers beyond the OEM. Measurement of supplier buyer relationship indicates the intensity of the relationship. The correlation between the market and technology competiveness with supplier involvement in product development is investigated. The study has shown that supplier's involvement is significant for firm's competitive position. However, the relationship has not given the suppliers more access to new market or makes them more responsive to market needs. But, the high percentage of partnership that is growing and established indicates a positive outlook. The efforts with regards to maintaining a good relationship by both parties is necessary to ensure that the collaboration effort is a successful one. It is envisaged that these activities will contribute towards building a Malaysian industry base that can meet current and future technology and competitive needs of the industry in a global competitive situation.
Dietary Polyphenols Increase Paraoxonase 1 Gene Expression by an Aryl Hydrocarbon Receptor-Dependent Mechanism

ABSTRACT Human paraoxonase 1 (PON-1) is a serum high-density lipoprotein-associated enzyme mainly secreted by the liver. It has endogenous and exogenous substrates and displays protective properties with respect to cardiovascular disease and organophosphate intoxication. In the HuH7 human hepatoma cell line, PON-1 activity and mRNA levels were increased by dietary polyphenolic compounds such as quercetin but also by toxic ligands of the aryl hydrocarbon receptor (AhR) such as 3-methylcholanthrene (3-MC). However, the 2,3,7,8-tetrachlorobenzo(p)dioxin (TCDD) was a poor inducer. Transient and stable transfection assays indicated that these compounds increased the PON-1 gene promoter activity in an AhR-dependent manner, since their effect was inhibited by 7-keto-cholesterol and AhR-directed short interfering RNA. Deletions and mutations studies showed that a xenobiotic responsive element (XRE)-like sequence within the PON-1 promoter mediated the effect of 3-MC and quercetin. In contrast with consensus XREs from the cytochrome P450 1A1 gene, the PON-1 XRE-like element mediated preferentially the effect of quercetin compared to the results seen with TCDD. Furthermore, AhR binding to this element was preferentially activated by quercetin. These observations provide a molecular mechanism for the regulation of the cardioprotective enzyme PON-1 by polyphenols. They suggest also that AhR ligands may differentially regulate gene expression depending on the DNA target sequence.
Impact of Oxidative Stress on the Endothelial Dysfunction of Children and Adolescents With Type 1 Diabetes Mellitus: Protection by Superoxide Dismutase?

Diabetes mellitus is associated with endothelial dysfunction and oxidative stress (OS). We investigated whether these abnormalities are interrelated in children and adolescents with type 1 diabetes mellitus (T1DM) and if early OS markers predictive of vascular dysfunction can be identified. Thirty-five T1DM patients were matched for sex, age, height, and weight with nondiabetic subjects as healthy controls (CO). Flow-mediated dilatation (FMD), carotid intima media thickness (IMT), and OS status in fasting blood were measured. Diabetic children had impaired FMD (6.68 ± 1.98 versus 7.92 ± 1.60% in CO, p = 0.004), which was more pronounced in boys. The degree of FMD impairment was not related to the lower plasma levels of antioxidants or to the higher glucose, glycation, lipids, and peroxidation products. Erythrocyte superoxide dismutase activity, copper/zinc superoxide dismutase (Cu/Zn SOD), was higher in diabetic subjects (1008 ± 224 versus 845 ± 195 U/g Hb in CO, p = 0.003) and was positively associated with FMD. After correcting for diabetes and gender, the subgroup of children with high Cu/Zn SOD (>955 U/g Hb) had a significantly better FMD (p = 0.035). These results suggest that higher circulating Cu/Zn SOD could protect T1DM children and adolescents against endothelial dysfunction. Low Cu/Zn SOD is a potential early marker of susceptibility to diabetic vascular disease.
Psychometric Evaluation of the EMO and the SUS in the Context of a Large-Sample Unmoderated Usability Study

This article describes the psychometric properties of the Emotional Metric Outcomes (EMO) questionnaire and the System Usability Scale (SUS) using data collected as part of a large-sample unmoderated usability study (n = 471). The EMO is a concise multifactor standardized questionnaire that provides an assessment of transaction-driven personal and relationship emotional outcomes, both positive and negative. The SUS is a well-known standardized usability questionnaire designed to assess perceived usability. In previous research, psychometric evaluation using data from a series of online surveys showed that the EMO and its component scales had high reliability and concurrent validity with loyalty and overall experience metrics but did not find the expected four-factor structure. Previous structural analyses of the SUS have had mixed results. Analysis of the EMO data from the usability study revealed the expected four-factor structure. The factor structure of the SUS appeared to be driven by item tone. The estimated reliability of the SUS (.90) was consistent with previous estimates. The EMO and its subscales were also quite reliable, with the estimates of reliability for the various EMO scales ranging from . 86 to . 96. Regression analysis using SUS, EMO, and Effort as predictors revealed different key drivers for the outcome metrics of Satisfaction and Likelihood-to-Recommend. The key recommendations are to include the EMO as part of the battery of poststudy standardized questionnaires, along with the SUS (or similar questionnaire), but to be cautious in reporting SUS subscales such as Usable and Learnable.
Individual and county level predictors of asthma related emergency department visits among children on Medicaid: A multilevel approach

ABSTRACT Objective: Disparities in asthma outcomes are well documented in the United States. Interventions to promote equity in asthma outcomes could target factors at the individual and community levels. The objective of this analysis was to understand the effect of individual (race, gender, age, and preventive inhaler use) and county-level factors (demographic, socioeconomic, health care, air-quality) on asthma emergency department (ED) visits among Medicaid-enrolled children. This was a retrospective cohort study of Medicaid-enrolled children with asthma in 29 states in 2009. Multilevel regression models of asthma ED visits were constructed utilizing individual-level variables (race, gender, age, and preventive inhaler use) from the Medicaid enrollment file and county-level variables reflecting population and health system characteristics from the Area Resource File (ARF). County-level measures of air quality were obtained from Environmental Protection Agency (EPA) data. Results: The primary modifiable risk factor at the individual level was found to be the ratio of long-term controller medications to total asthma medications. County-level factors accounted for roughly 6% of the variance in the asthma ED visit risk. Increasing county-level racial segregation (OR=1.04, 95% CI=1.01-1.08) was associated with increasing risk of asthma ED visits. Greater supply of pulmonary physicians at the county level (OR=0.81, 95% CI=0.68-0.97) was associated with a reduction in risk of asthma ED visits. Conclusions: At the patient care level, proper use of controller medications is the factor most amenable to intervention. There is also a societal imperative to address negative social determinants, such as residential segregation.
Prenatal detection of trisomy 21: combined experience of two British hospitals

A retrospective study was performed to determine the detection rate of trisomy 21 in two British hospitals using a combination of: (1) second trimester serum screening with maternal age, αFP and hCG; (2) karyotyping for raised maternal age and high background risk of aneuploidy; and (3) second trimester fetal anomaly ultrasonography at 18–22 week gestation. 36 410 women with a median age of 27 years were studied. Trisomy 21 detected by the combination of methods in both hospitals was compared with the actual number of pregnancies affected by trisomy 21, to determine the detection rate. Serum screening as the backbone of the service detected 31/48 (65%) trisomy 21 affected pregnancies. Karyotyping for maternal age and previous aneuploidy detected eight trisomy 21 affected pregnancies, and second trimester ultrasound a further six, giving a total detection rate of 45/56 (80%). Thus, the detection rate of trisomy 21 in our population is 65% by serum screening alone. This is similar to demonstration projects, but the addition of second trimester ultrasonography and karyotyping for maternal age and prior risk, contributes further to improve the overall sensitivity to 80%. The invasive procedure rate was 4.8% of all women. Copyright © 2000 John Wiley & Sons, Ltd.
Stress induced lipid production in Chlorella vulgaris: Relationship with specific intracellular reactive species levels

Microalgae have significant potential to be an important alternative energy source, but the challenges to the commercialization of bio‐oil from microalgae need to be overcome for the potential to be realized. The application of stress can be used to improve bio‐oil yields from algae. Nevertheless, the understanding of stress effects is fragmented due to the lack of a suitable, direct quantitative marker for stress. The lack of understanding seems to have limited the development of stress based strategies to improve bio‐oil yields, and hence the commercialization of microalgae‐based bio‐oil. In this study, we have proposed and used the specific intracellular reactive species levels (siROS) particularly hydroxyl and superoxide radical levels, separately, as direct, quantitative, markers for stress, irrespective of the type of stress induced. Although ROS reactions are extremely rapid, the siROS level can be assumed to be at pseudo‐steady state compared to the time scales of metabolism, growth and production, and hence they can be effective stress markers at particular time points. Also, the specific intracellular (si‐) hydroxyl and superoxide radical levels are easy to measure through fluorimetry. Interestingly, irrespective of the conditions employed in this study, that is, nutrient excess/limitation or different light wavelengths, the cell concentrations are correlated to the siROS levels in an inverse power law fashion. The composite plots of cell concentration (y) and siROS (x) yielded the correlations of y = k1 · x−0.7 and y = k2 · x−0.79, for si‐hydroxyl and si‐superoxide radical levels, respectively. The specific intracellular (si‐) neutral lipid levels, which determine the bio‐oil productivity, are related in a direct power law fashion to the specific hydroxyl radical levels. The composite plot of si‐neutral lipid levels (z) and si‐hydroxyl radical level (x) yielded a correlation of z = k3 · x0.65. More interestingly, a nutrient shift caused a significant change in the sensitivity of neutral lipid accumulation to the si‐hydroxyl radical levels. Biotechnol. Bioeng. 2013; 110: 1627–1636. © 2013 Wiley Periodicals, Inc.
The Role of Predictability in Intonational Variability

Predictability is known to affect many properties of speech production. In particular, it has been observed that highly predictable elements (words, syllables) are produced with less phonetic prominence (shorter duration, less peripheral vowels) than less predictable elements. This tendency has been proposed to be a general property of language. This paper examines whether predictability is correlated with fundamental frequency (F0) production, through analysis of experimental corpora of American English. Predictability was variously defined as discourse mention, utterance probability, and semantic focus. The results revealed consistent effects of utterance probability and semantic focus on F0, in the expected direction: less predictable words were produced with a higher F0 than more predictable words. However, no effect of discourse mention was observed. These results provide further empirical support for the generalization that phonetic prominence is inversely related to linguistic predictability. In addition, the divergent results for different predictability measures suggests that the parameterization of predictability within a particular experimental design can have significant impact on the interpretation of results, and that it cannot be assumed that two measures necessarily reflect the same cognitive reality.
Committee Decisions under Majority Rule: An Experimental Study

This article reports the findings of a series of experiments on committee decision making under majority rule. The committee members had relatively fixed preferences, so that the process was one of making decisions rather than one of problem solving. The predictions of a variety of models drawn from Economics, Sociology, Political Science and Game Theory were compared to the experimental results. One predictive concept, the core of the noncooperative game without side payments (equivalent to the majority rule equilibrium) consistently performed best. Significantly, however, even when such an outcome did not exist, the experimental results did not display the degree of unpredictability that some theoretical work would suggest. An important subsidiary finding concerns the difference between experiments conducted under conditions of high stakes versus those conducted under conditions of much lower stakes. The findings in the two conditions differed considerably, thus calling into question the political applicability of numerous social psychological experiments in which subjects had little or no motivation.
A Secure and Efficient ID-Based Aggregate Signature Scheme for Wireless Sensor Networks

Affording secure and efficient big data aggregation methods is very attractive in the field of wireless sensor networks (WSNs) research. In real settings, the WSNs have been broadly applied, such as target tracking and environment remote monitoring. However, data can be easily compromised by a vast of attacks, such as data interception and data tampering, etc. In this paper, we mainly focus on data integrity protection, give an identity-based aggregate signature (IBAS) scheme with a designated verifier for WSNs. According to the advantage of aggregate signatures, our scheme not only can keep data integrity, but also can reduce bandwidth and storage cost for WSNs. Furthermore, the security of our IBAS scheme is rigorously presented based on the computational Diffie–Hellman assumption in random oracle model.
Peroxisome proliferator-activated receptor gamma1 expression in porcine white blood cells: dynamic regulation with acute endotoxemia.

Peroxisome proliferator-activated receptor gamma (PPARgamma), a primary regulator of adipocyte differentiation, has been implicated in the regulation of monocyte and macrophage function in vitro. We report that PPARgamma protein is expressed in porcine peripheral white blood cells (WBC), and that PPARgamma1 but not gamma2 mRNA predominates. Additionally, we provide the first evidence that in vivo lipopolysaccharide challenge (LPS, 25 microg/kg BW) causes a dynamic increase in PPARgamma protein expression in peripheral WBC (P < 0.05). PPARgamma expression was increased 2-fold over basal (1 hr post-LPS), was maximal by 4 hr (3-fold), and was normalized to control by 8 hr post-LPS. Changes in PPARgamma expression coincided with or closely followed LPS-induced changes in plasma cortisol, TNF-alpha, insulin, IGF-1, glucose, and free fatty acids. These data suggest that induction of PPARgamma expression in WBC may play a role in host response to acute inflammatory challenge and may prove to be an important target of anti-inflammatory therapies.
A New Framework for Measuring 2D and 3D Visual Information in Terms of Entropy

In recent years, the problem of how to more perceptually quantify visualizations of an object and a surface displayed in 3D space between the human eye and a display has been more prominent with rapid increase in the demand for 3D/ultrahigh-definition content. In order to quantify the content information in terms of human visual perception, it is necessary to measure the visual information of 2D and 3D videos accurately in accordance with the human visual system. In this paper, we investigate a new framework for expressing visual information in bits termed visual entropy, based on information theory. 2D visual entropy (2DVE) is composed of two major components: 1) texture entropy on the 2D surface and 2) depth entropy based on the monocular cue. In contrast, 3D visual entropy (3DVE) includes the depth entropy based on the binocular cue in addition to the 2DVE. A series of simulations is conducted to demonstrate the effectiveness of visual entropy, including the degree of accuracy needed to represent perceptual information by means of the texture and monocular and binocular depth entropies. In the simulation results, two successful example applications are also provided, whereby visual entropy is applied to the problems of predicting the visual discomfort experienced when viewing 3D displays and of analyzing performance tradeoffs between 2D and 3D contents.
Phospholipids in mammalian semen.

The earliest investigations on the lipids of spermatozoa are those of Miescher (1878) who reported that the ether-extractable material in the spermatozoa of bull and salmon was about 50 % lecithin. At that time, of course, the term lecithin had no precise chemical connotation. However, a high concentration of phospholipid was subsequently shown to be a general characteristic of spermatozoa where it is present mainly in the mid-pieces and tails. The first inquiries into possible metabolic roles for the phospholipids of spermatozoa were made by Lardy & Phillips (1941 a, b). These authors
The Maternal Lifestyle Study (MLS): effects of prenatal cocaine and/or opiate exposure on auditory brain response at one month.

OBJECTIVE To study absolute and interpeak latencies of the auditory brain response in infants exposed to cocaine and/or opiates in utero.Study design The sample included 477 exposed and 554 comparison infants matched for race, sex, and gestational age. Mothers were recruited at 4 urban university-based centers; most were black, receiving public assistance, and had received adequate prenatal care. Exposure was determined by meconium assay and self-report with alcohol, marijuana, and tobacco present in both groups. At 1 month, infants were tested by masked examiners with the auditory brain response. RESULTS Analyses were conducted for exposed and comparison groups and for level of prenatal cocaine exposure with adjustment for covariates (alcohol, marijuana, tobacco, gestational age at birth, social class, and site). Heavy prenatal cocaine exposure (>/=3 days per week, first trimester) led to an increase in the I-III, I-V, and III-V interpeak latencies and to a shorter latency to peak I. Infants with prenatal opiate exposure showed a longer latency to peak V and a longer III-V interpeak latency. CONCLUSIONS Prenatal cocaine and/or opiate exposure affects neural transmission. Detection of these effects requires a large sample with control for gestational age, other drugs, and level of cocaine use.
Serum Retinol-binding Protein 4 Is Independently Associated With Pediatric NAFLD and Fasting Triglyceride Level

Objectives: Nonalcoholic fatty liver disease (NAFLD) is identified as a major liver disease in children. The present study aimed to identify the prevalence and predictors of pediatric NAFLD and the correlation between serum retinol-binding protein 4 (RBP4) levels and metabolic characteristics in children. Methods: A total of 748 schoolchildren, ages 6 to 12 years, were enrolled in 2009. The body weight and height were measured in the morning before intake. Laboratory tests included overnight fasting serum lipids, insulin, liver enzymes, and RBP4 levels. Hepatic steatosis was determined by ultrasound in 219 volunteers. Results: The rates of NAFLD were 3% in the normal-weight, 25% in the overweight, and 76% in the obese children. Twenty (22%) of obese children had abnormal alanine aminotransferase (ALT) levels. In children with NAFLD, younger age and higher body mass index (BMI), insulin/homeostasis model of assessment, and male sex rate were associated with abnormal liver function. Stepwise increments in BMI, insulin, homeostasis model of assessment, and ALT were found in children with normal livers to simple steatosis, and to steatosis with abnormal ALT. Multiple logistic regression analysis confirmed that serum RBP4 levels (P = 0.048), ALT (P = 0.048), and BMI (P < 0.001) were independently predictors of pediatric NAFLD. Moreover, multiple linear regression analysis revealed that only serum triglycerides levels were positively related to RBP4 levels (P < 0.001). Conclusions: Higher RBP4 and ALT levels as well as BMI are independently associated with pediatric NAFLD in Taiwan. In addition, an increment in RBP4 levels was positively correlated to hypertriglyceridemia in children.
Improving Drug Prescribing in a Primary Care Practice

A model for improving physician prescribing that utilizes computerized feedback was studied in a family medicine residency practice. Resident and faculty physicians were stratified by level of experience and randomized into two groups. For 9 months the experimental group received monthly printouts identifying drugs they had prescribed by brand name with estimates of cost savings that might have been realized by prescribing generic drugs. The control group received no feedback. Prescription monitoring of both groups continued for 12 months after all feedback had ceased. Median weighted rates of generic prescribing for the experimental physicians were 14% for the baseline, 67% for the feedback, and 54% for the follow-up periods. Rates for the control physicians for the three periods were 32%, 37% and 31%, respectively. The increase in generic prescribing by physicians in the experimental group was significantly greater than for control physicians (P = 0.01). The feedback model improved rates of generic prescribing but should be evaluated for broader areas of physician prescribing.
The Evolving Role of the Instructor in the Digital Age

In this era of student-centered, collaborative, constructivist learning, augmented by social networks and other virtual environments featuring learner autonomy, self-direction and independence, the role of instructors in online education is undergoing continuous evolution since the advent of the Internet, and the proliferation of Learning Management Systems (LSM) to support teaching and learning. This chapter examines the role of the online instructor, and indeed, poses the provocative question: does there remain a useful and meaningful role for what is arguably the increasingly ‘invisible’ instructor in many online settings. Factors that contribute to this phenomenon, such as the proliferation of new technology, the emphasis on self-directed learning, a changing student clientele, emerging modes of assessment, etc. are noted. Findings from a various studies of student attitudes, behaviors, and perceptions of what is critical for success in online courses are highlighted, including data suggesting that the role of instructors and the features of Learning Management Systems are relatively minor factors for achieving success in online learning. The implications of these trends for the future role of the professoriate are also considered.