Miracle-dz/UniFAR-FTUs huggingface dataset:
Block diagonalization with interference control for energy efficient downlink

Block diagonalization is a linear precoding technique which eliminates the multi-user interference at the transmitter side by creating parallel orthogonal single user links. In this technique, the transmit diversity order is fixed for each user and only power can be controlled to satisfy SINR requirements. This restricts the degrees of freedom available for resource allocation and limits the energy efficiency of the power allocation schemes performed by the base-station. In this contribution we present a new extension to block diagonalization where spatial degrees of freedom can also be adjusted in addition to power and bandwidth. With this new technique, it is possible to serve multiple users with different rate requirements by tolerating a controllable amount of interference. The amount of interference is controlled through an algebraic parameter that can be tuned in order to allow energy efficient power allocation.
A Comparison Study of Single-Parent Families Living on Remote, Rural Islands and in Urban Settings in Japan

Background: Nursing interventions that aim to enhance the family environment are necessary to help single-parent families with children to improve family functioning. The cultural and social factors that are unique to Japan’s remote islands should be considered to assess the influence of this unique setting on family functioning. Purpose: The objectives of this study were to evaluate the family functioning of child-rearing single-parent families living in different environments and to investigate the association between family demographics and family functioning. Methods: A self-administered questionnaire, the Japanese version of the Survey of Family Environment, was used to evaluate the sufficiency of family functioning. The participants were families with children enrolled in nurseries and kindergartens who were either living in remote, rural islands or in an urban city on the mainland in Japan. Results: Family functioning was significantly higher for single-parent families living on the islands than for those living in the city in terms of media use, participation in community activities, and the collaboration of family members in child-rearing. Family functioning of single-parent families correlated significantly with household income, the parent’s gender, family members’ health, and family life cycle. Conclusions/Implications for Practice: Single-parent families living on Japanese offshore islands maintained family functioning through mutual support and the effective use of information technology. Nevertheless, single-parent families require additional support to improve their healthcare and financial situations.
Melatonin regulates Arabidopsis root system architecture likely acting independently of auxin signaling

Abstract: Melatonin (N‐acetyl‐5‐methoxytryptamine) is a tryptophan‐derived signal with important physiological roles in mammals. Although the presence of melatonin in plants may be universal, its endogenous function in plant tissues is unknown. On the basis of its structural similarity to indole‐3‐acetic acid, recent studies mainly focusing on root growth in several plant species have suggested a potential auxin‐like activity of melatonin. However, direct evidence about the mechanisms of action of this regulator is lacking. In this work, we used Arabidopsis thaliana seedlings as a model system to evaluate the effects of melatonin on plant growth and development. Melatonin modulated root system architecture by stimulating lateral and adventitious root formation but minimally affected primary root growth or root hair development. The auxin activity of melatonin in roots was investigated using the auxin‐responsive marker constructs DR5:uidA, BA3:uidA, and HS::AXR3NT‐GUS. Our results show that melatonin neither activates auxin‐inducible gene expression nor induces the degradation of HS::AXR3NT‐GUS, indicating that root developmental changes elicited by melatonin were independent of auxin signaling. Taken together, our results suggest that melatonin is beneficial to plants by increasing root branching and that root development processes elicited by this novel plant signal are likely independent of auxin responses.
How do investors price stocks?—Evidence with real‐time data from Vietnam

Our paper employs a dataset that comprises real-time data, which, in our study, is defined as the best known data available to investors at the time of making decision. The research was inspired by comments by industry leaders at an international conference in finance in Vietnam in 2016, basically implying that academic research findings were not useful to investors because they had not done in the way that investors think and do. Drawing on an alike experiment study using realtime data for a period from October 2010 to April 2014, our paper documents that the value and liquidity effect do not exist in Vietnam and the size effect is weak. Specifically, we find that growth and high liquidity stocks outperform and do not find strong evidence for the outperformance of small stocks. This finding contradicts the general literature, which suggests that value, low liquidity and small stocks outperform, but supports similar contradicting findings for emerging markets. The findings from our research are important to investors in Vietnam market because they are drawn on the decision making basis that investors in this market normally do. Our research findings also suggest the use of a multifactor pricing model that is relevant for valuing stocks in Vietnam. In addition, to check the reliability of our dataset and the robustness of our conclusions, we repeated the same procedure using two samples of historical data and compared with results from our data. The additional analysis confirms the reliability of our data and findings.
Plasma thrombopoietin concentrations in thrombocytopenic and non‐thrombocytopenic patients in a neonatal intensive care unit

Thrombocytopenia is a frequent occurrence in the neonatal intensive care unit (NICU), but the role of thrombopoietin (Tpo) in the pathophysiology is unknown. We obtained serial plasma Tpo concentrations in 20 thrombocytopenic neonates in our NICU, and performed bone marrow studies in 15. The initial Tpo levels ranged from undetectable (<41 pg/ml) to 1112 pg/ml and did not correlate with gestational age or platelet count. Neonates with decreased marrow megakaryocytes did not have plasma Tpo levels as high as those reported in adults, particularly in small for gestational age infants (Tpo < 300 pg/ml). In 14/15 neonates followed until resolution, the Tpo concentration decreased as the platelet count increased.
Factors related to physical therapy students' decisions to work with elderly patients.

The purpose of this study was to determine the factors related to physical therapy students' decisions to work with elderly patients subsequent to graduation. Questionnaires, distributed to students in graduating classes of seven entry-level master's degree programs and seven baccalaureate degree programs, were returned by 326 participants. The questionnaires included 20 questions within four categories--biographical (3), experiential (7), perceived socioeconomic (3), and attitudinal (7) factors--plus 1 question to determine whether students intended to work with elderly patients. Chi-square tests (p less than .05) determined significant relationships between the participants' intentions to work with elderly people and their answers to 10 of the questions (1 biographical, 3 experiential, and 6 attitudinal). The answers to 1 of these experiential questions and 4 of these attitudinal questions were significant at the . 001 level. No perceived socioeconomic questions were significant. Our results may help in planning strategies to encourage physical therapy students to work with elderly people.
Intramammary administration of gentamicin as treatment for experimentally induced Escherichia coli mastitis in cows.

In 8 Holstein cows, 50 colony-forming units (CFU) of Escherichia coli was administered into 1 mammary gland. Infections were established in all inoculated glands. In 4 of the 8 cows, 500 mg of gentamicin sulfate was administered by intramammary infusion 14 hours after inoculation; the other 4 cows were untreated controls. Infusions of gentamicin also were given after each of the 3 successive milkings after the initial infusion, so that a total dose of 2 g of gentamicin was given to each of the treated cows. During the 33-hour treatment period and for the first milking after the last infusion of gentamicin, the treated cows had a mean gentamicin concentration of greater than or equal to 31.0 micrograms/ml in milk samples that were collected from inoculated quarters immediately before each milking. Concentrations of 0.34 and 0.69 micrograms of gentamicin/ml were detected in milk from 2 cows at 8 days after inoculation with E coli. Mean serum concentrations of gentamicin were greater than or equal to 0.37 micrograms/ml throughout the treatment period and the first 12 hours after the last infusion, with a mean peak concentration of 0.96 micrograms/ml at 24.4 hours. The range of peak concentration of gentamicin detected in urine from all treated cows was 42 to 74.4 micrograms/ml. Peak concentration of E coli in milk in the treated cows (6.08 +/- 1.02 log10 CFU/ml) did not significantly (P greater than 0.05) differ from that of the control cows (5.26 +/- 1.00 log10 CFU/ml). Similarly, mean duration of infection in the treated cows (54 hours) did not differ significantly from that of the control cows (48 hours). (ABSTRACT TRUNCATED AT 250 WORDS)
Developmental changes in calretinin expression in GABAergic and nonGABAergic neurons in monkey striate cortex

The development of the calcium‐binding protein calretinin (CaR) and its co‐localization with GABA was studied in the striate cortex of Macaca monkeys from fetal day (Fd) 45 to adult. At Fd45, early neurons resembling Cajal‐Retizus cells are stained in the marginal zone (MZ). At Fd55 the MZ is filled with CaR+ Cajal‐Retzius cells and their processes, and scattered CaR+ cells are also found in deep cortical plate (CP), intermediate zone (IZ), and subventricular zone (SVZ). At Fd66, a band of CaR+ fibers appears in the IZ, corresponding to the location of the geniculocortical axons. This fiber band labels heavily until Fd130 but then ceases to be immunoreactive by postnatal (P) 16 weeks. At Fd85–101, the number of CaR+ cells in the CP, SVZ, and ventricular zone (VZ) reaches its highest cell density. After Fd130, CaR+ cells are concentrated in layer II and upper layer III, and this distribution changes little into adulthood. After mid‐gestation, there is a progressive loss of CaR+ cell bodies and processes in the MZ, and these are rare in the adult cortex. Just before birth, a weakly stained CaR+ cell band appears in layer NA at the border between layer NA and IVB, but this band disappears immediately after birth. Another CaR+ cell band appears transiently in upper layer V just below the border with layers IV at P6 months. These results suggest that CaR is expressed early in fetal development in the cell populations that are immunoreactive for CaR in the adult. However, developmental events related to cortical maturation during late prenatal and early postnatal stages result in transient expression of CaR in neurons that are not immunoreactive for CaR in the adult.
Customer perceived value in high growth firms

Scholars have asserted that a key factor that differentiates high growth firms (HGFs) from other firms is their ability to create value for their customers. This paper contributes to the literature by empirically exploring this relationship. Drawing on comparative cohorts of eleven HGFs and ten non-HGFs in Scotland, this paper finds that the HGFs were much more likely than their non-HGF counterparts to be positively influencing customer perceived value, which is considered as an important enabler of firm performance and growth. In addition to its empirical contribution to the high growth entrepreneurship literature, this paper raises issues for future research.
Are Men Or Women More Overconfident In Investment Decision-Making?

Stock investment decisions are actions that will generate the highest expected return. This study aims to determine the influence of gender toward overconfidence and investment decision-making and to test whether there are differences in overconfidence between men and women. The population is investors in the city of Medan, Sample is from investors who are actively investing online incorporated in a securities company located in Medan. This study used primary data by questionnaires with sample consisted of 120 respondents. Data analysis using descriptive statistical analysis, regression and Mann-Whitney Test. The results showed no significant influence with alpha five percent between gender toward overconfidence and investment decision-making; there has influence overconfidence toward investment decision-making. There is no difference in overconfidence between men and women. The result of this research is that securities firms can offer investments with different levels of risk to men and women simultaneously. Keywords–gender; overconfidence; investment decision; investment decision-making
Lungs of patients with acute respiratory distress syndrome show diffuse inflammation in normally aerated regions: A [18F]-fluoro-2-deoxy-D-glucose PET/CT study

Objective: Neutrophilic inflammation plays a key role in the pathogenesis of acute respiratory distress syndrome (ARDS) and acute lung injury (ALI). Positron emission tomography (PET) with [18F]-fluoro-2-deoxy-d-glucose (18FDG) can be used to image cellular metabolism that, during lung inflammatory processes, likely reflects neutrophils activity. The aim of this study was to assess the magnitude and regional distribution of inflammatory metabolic activity in the lungs of patients with ALI/ARDS by PET with 18FDG. Design: Prospective clinical investigation. Patients: Ten patients with ALI/ARDS; four spontaneously breathing and two mechanically ventilated subjects, without known lung disease, served as controls. Interventions: In each individual we performed an 18FDG PET/computed tomography of the thorax. Measurements and Main Results: 18FDG cellular influx rate constant (Ki) was computed for the imaged lung field and for regions of interest, grouping voxels with similar density. In all patients with ALI/ARDS, Ki was higher than in controls, also after accounting for the increased lung density. Ki values differed greatly among patients, but in all patients Ki of the normally aerated regions was much higher (2- to 24-fold) than in controls. Whereas in some patients the highest Ki values corresponded to regions with the lowest aeration, in others these regions had lower Ki than normally and mildly hypoaerated regions. Conclusion: In patients with ALI/ARDS, undergoing mechanical ventilation since days, the metabolic activity of the lungs is markedly increased across the entire lung density spectrum. The intensity of this activation and its regional distribution, however, vary widely within and between patients.
F2‐Isoprostanes as Markers of Oxidant Stress: An Overview

The isoprostanes are a unique series of prostaglandin‐like compounds formed in vivo via a non‐enzymatic mechanism involving the free radical–initiated peroxidation of arachidonic acid. This unit summarizes selected aspects regarding current knowledge of these compounds and their value as markers of oxidative injury. Novel aspects related to the biochemistry of isoprostane formation are discussed and methods by which these compounds can be analyzed and quantified are summarized. A considerable portion of this unit examines the utility of F2‐isoprostanes as markers of oxidant injury in vitro and in vivo. Numerous studies carried out over the past decade have shown that these compounds are extremely accurate measures of lipid peroxidation in animals and humans and have illuminated the role of oxidant injury in a number of human diseases.
Inhibition of the mammalian target of rapamycin complex 1 signaling pathway reduces itch behaviour in mice

Abstract Activated mammalian target of rapamycin (P-mTOR) has been shown to maintain the sensitivity of subsets of small-diameter primary afferent A-nociceptors. Local or systemic inhibition of the mTOR complex 1 (mTORC1) pathway reduced punctate mechanical and cold sensitivity in neuropathic pain and therefore offered a new approach to chronic pain control. In this study, we have investigated the effects of the rapamycin analog temsirolimus (CCI-779) on itch. Bouts of scratching induced by the histamine-dependent pruritogenic compound 48/80 and histamine-independent pruritogens, chloroquine and SLIGRL-NH2, injected intradermally were significantly reduced by local (intradermal) or systemic (intraperitoneal, i.p.) pretreatment with CCI-779. We also investigated the action of metformin, a drug taken to control type 2 diabetes and recently shown to inhibit mTORC1 in vivo. Although the response to nonhistaminergic stimuli was reduced at all of the time points tested, scratching to compound 48/80 was modified by metformin only when the drug was injected 24 hours before this pruritogen. We also examined the colocalization of P-mTOR with gastrin-releasing peptide, a putative marker for some itch-sensitive primary afferents, and found that P-mTOR was coexpressed in less than 5% of gastrin-releasing peptide–positive fibers in the mouse skin. Taken together, the data highlight the role that P-mTOR-positive A-fibers play in itch signaling and underline the importance of the mTORC1 pathway in the regulation of homeostatic primary afferent functions such as pain and itch. The actions of the antidiabetic drug metformin in ameliorating nonhistamine-mediated itch also suggest a new therapeutic route for the control of this category of pruritus.
Prognostic Significance of Risk Stratifiers of Mortality, Including T Wave Alternans, After Acute Myocardial Infarction: Results of a Prospective Follow‐Up Study

Noninvasive Risk Assessment Including TWA After AMI. Introduction: Occurrence of sustained microvolt‐level T wave alternans (TWA) at a specified heart rate has been suggested to predict life‐threatening arrhythmic events, but its prognostic value has not been well established in patients who survived an acute myocardial infarction (AMI). The purpose of this prospective study was to assess the predictive significance of various noninvasive risk indicators of mortality, including TWA, in consecutive post‐AMI patients with optimized medical therapy.
CHALLENGES AND OPPORTUNITIES FOR THE IMPLEMENTATION OF H-BIMWITH REGARDS TO HISTORICAL INFRASTRUCTURES:A CASE STUDY OF THE PONTE GIORGINI IN CASTIGLIONE DELLA PESCAIA(GROSSETO – ITALY)

Abstract. Historical Building Information Modeling (H-BIM) has been widely documented in literature and is becoming more popular with government bodies, who are increasingly choosing to make its use mandatory in public procurements and contracts. Although the system seems to be one of the best approaches for managing data and driving the decision-making process, several difficulties arise due to the amount of effort required in the initial phases, when the data derived from a geometrical survey must be converted into parametric elements. Moreover, users must decide on a “level of geometrical simplification” a long time in advance, and this inevitably leads to a loss of geometrical data. From this perspective, our research describes a procedure to optimize the workflow of information for existing artefacts, in order to achieve a “lean” H-BIM. In this article, we will analyse two aspects: the first relates to the level of accuracy in a digital model created from the two different point clouds achieved from laser scanner and form images, while the second concerns the conversion of this information into parametric elements (Building Object Models- BOMs) that need to have specific characteristics. The case study we are presenting is the “Ponte Giorgini” (“Giorgini Bridge”) in Castiglione della Pescaia (Grosseto – Italy).
Inflammatory Disease and Lymphomagenesis Caused by Deletion of the Myc Antagonist Mnt in T Cells

ABSTRACT Mnt is a Max-interacting protein that can antagonize the activities of Myc oncoproteins in cultured cells. Mnt null mice die soon after birth, but conditional deletion of Mnt in breast epithelium leads to tumor formation. These and related data suggest that Mnt functions as a tumor suppressor. Here we show that conditional deletion of Mnt in T cells leads to tumor formation but also causes inflammatory disease. Deletion of Mnt caused increased apoptosis of thymic T cells and interfered with T-cell development yet led to spleen, liver, and lymph node enlargement. The proportion of T cells in the spleen and lymph nodes was reduced, and the numbers of cells in non-T-cell immune cell populations were elevated. The disruption of immune homeostasis is linked to a strong skewing toward production of T-helper 1 (Th1) cytokines and enhanced proliferation of activated Mnt-deficient CD4+ T cells. Consistent with Th1 polarization in vivo, extensive intestinal inflammation and liver necrosis developed. Finally, most mice lacking Mnt in T cells ultimately succumbed to T-cell lymphoma. These results strengthen the argument that Mnt functions as a tumor suppressor and reveal a critical and surprising role for Mnt in the regulation of T-cell development and in T-cell-dependent immune homeostasis.
Retinoid Receptors Involved in the Effects of Retinoic Acid on Rat Testis Development1

Abstract We have previously shown that retinoic acid (RA) is able to act on the development of Leydig, Sertoli, and germ cells in the testis in culture (Livera et al., Biol Reprod 2000; 62:1303–1314). To identify which receptors mediate these effects, we have now added selective agonists and antagonists of retinoic acid receptors (RARs) or retinoid X receptors (RXRs) in the same organotypic culture system. The RAR α agonist mimicked most of the effects of RA on the cultured fetal or neonatal testis, whereas the RAR β, γ, and pan RXR agonists did not. The RAR α agonist decreased the testosterone production, the number of gonocytes, and the cAMP response to FSH of fetal testis explanted at 14.5 days postconception (dpc). The RAR α agonist disorganized the cords of the 14.5-dpc cultured testis and increased the cord diameter in cultured 3-days-postpartum (dpp) testis in the same way as RA. All these RA effects could be reversed by an RAR α antagonist and were unchanged by an RAR β/γ antagonist. The RAR β agonist, however, increased Sertoli cell proliferation in the 3-dpp testis in the same way as RA, and this effect was blocked by an RAR β antagonist. The RAR γ and the pan RXR agonists had no selective effect. These results suggest that all the effects of RA on development of the fetal and neonatal testis are mediated via RAR α, except for its effect on Sertoli cell proliferation, which involves RAR β.