Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of meal carbohydrate content on insulin requirements in type 1 diabetic patients treated intensively with the basal-bolus (ultralente-regular) insulin regimen.

OBJECTIVE In this study, we evaluated the effects of high-(55%) and low-(40%) carbohydrate diets on insulin requirements in nine type 1 diabetic subjects treated intensively with ultralente as basal insulin and regular insulin as premeal insulin adjusted to the carbohydrate content of meals. RESEARCH DESIGN AND METHODS Nine subjects were randomized in a crossover design to follow two diets consecutively for a period of 14 days each. A 3-day food diary was completed for each diet with the amount of carbohydrate in the mixed meals ranging from 21 to 188 g. Preprandial (5.9 vs. 6.1 mmol/l) and postprandial (8 vs. 8.9 mmol/l) capillary glucose and fructosamine (310 vs. 316 mumol/l) were comparable on both the low- and high-carbohydrate diets. RESULTS The assessment of meal carbohydrate content by the patients was excellent, with > 85% of cases falling within 15% of computer-assisted evaluation. When premeal regular insulin was prescribed in U/10 g of carbohydrate, the postprandial glycemic rise remained constant (2.4 +/- 2.8 mmol/l) over a wide range of carbohydrate ingested (21-188 g) and was not affected by the glycemic index, fiber, and caloric and lipidic content of the meals. This tight control was maintained during the low- and high-carbohydrate diet without any change in insulin requirements (breakfast, 1.5 vs. 1.5 U/10 g of carbohydrate; lunch, 1.0 vs. 1.0; supper, 1.1 vs. 1.2) and in basal ultralente insulin requirements (22.5 vs. 21.4 U/day). CONCLUSIONS These results indicate that in type 1 diabetic subjects 1) increasing the amount of carbohydrate intake does not influence glycemic control if premeal regular insulin is adjusted to the carbohydrate content of the meals; 2) algorithms based on U/10 g of carbohydrate are effective and safe, whatever the amount of carbohydrate in the meal; 3) the glycemic index, fiber, and lipidic and caloric content of the meals do not affect premeal regular insulin requirements; 4) wide variations in carbohydrate intake do not modify basal (ultralente) insulin requirements; and, finally 5) the ultralente-regular insulin regimen allows dissection between basal and prandial insulin requirements, so that each can be adjusted accurately and independently.
Robust probabilistic conflict prediction for sense and avoid

Safe integration of Unmanned Aircraft Systems (UAS) into the National Airspace (NAS) will require the development and fielding of a sense-and avoid (SAA) capability to augment the traditional “see-and-avoid” regulations of manned aircraft. In this paper, we focus on the problem of correctly predicting an intruder trajectory. Approaches to intruder prediction are typically grouped into three categories: (i) nominal (deterministic), (ii) worst-case, and (iii) probabilistic. Most prediction algorithms envisioned for SAA fall within the probabilistic category. The benefit of a probabilistic approach is that it provides a mechanism to represent unknown variations in the intruder state at future times while also avoiding the overly conservative assumptions inherent in worst-case prediction. The downside of a probabilistic prediction is that it necessitates the construction of a stochastic model that is both useful for computation and accurately represents the “true” uncertainty in intruder predictions. Markovian structure and time-discretization are very common simplifying assumptions made to satisfy the first goal. Data-driven model tuning is typically used for the latter. However, a model is never exact, and a large quantity of data may be needed to guarantee the approximation accuracy is sufficient. The primary contribution of this paper is to present a fourth option for intruder prediction that we refer to as “robust probabilistic prediction. ” It is meant to address the risk of model mismatch associated with traditional probabilistic predictions. Conceptually, the idea is to specify only those features of the stochastic model that can be justified by data or expert judgment, leaving a full stochastic model underspecified. Typically, one needs a full stochastic model to “turn the crank” on risk calculations (e.g., probability of Near Mid-Air Collision). However, in robust probabilistic predictions, risk is defined as the worst-case risk over a space of stochastic models. This relaxes the need for ensuring that all elements of the model are correct. We show that a computationally efficient semi-definite program (SDP) can be used for performing the optimization over the space of stochastic models. Such an approach greatly reduces the risk of model mismatch as well as reducing the data burden required for model validation.
A novel data structure for adversarial VNet embeddings attack in cloud

Prior work by Pignolet et al. shows a new attacking methodology with which the attackers can disclose the whole cloud topology while deploying virtual networks in cloud, named "Topology Disclosure Attack". However, we discover some unreasonable attack assumptions in their model and this paper tries to develop a data structure, Query-Trie, providing topology disclosure attack a useful attack instruction. This new data structure not only enumerates all possible VNet request systematically but also provides efficient attack guideline. Hence, this Query Trie enables much more possible attack model in cloud in the future.
Optimal Public Debt Consolidation with Distributional Conflicts

In this paper, we adopt a Ramsey-optimal approach to the identification of debt reduction strategies, that is, the optimal policy mix for labor and capital income taxes, public expenditures and inflation designed to achieve an exogenous debt reduction path. Our model accounts for monopoly profits, limited asset market participation and asset holders' infrequent optimization of their portfolio composition between money holdings and other financial assets. The optimal policy envisages persistent reductions in public consumption and increases in taxes and inflation. Distributional conflicts arise between asset owners and the rest of the population. When asset holders interests are relatively less important in the planner's objective function, labor income taxes are drastically reduced whereas capital income taxes and inflation are increased. Just in this case the consolidation has short term expansionary effects.
Mouse Disp1 is required in sonic hedgehog-expressing cells for paracrine activity of the cholesterol-modified ligand

Previous studies have demonstrated that Disp1 function is essential for Shh and Ihh signaling in the mouse, and Disp1 gene dose regulates the level of Shh signaling activity in vivo. To determine whether Disp1 activity is required in Shh-producing cells for paracrine signaling in Shh target fields, we used a ShhGFP-Cre (here shortened to ShhCre) knock-in allele and a Disp1 conditional allele to knock down Disp1 activity specifically within Shh-producing cells. The resulting facial and neural tube phenotypes support the conclusion that the primary and probably exclusive role for Disp1 is within hedgehog protein-producing cells. Furthermore, using an allele that produces N-Shh (a noncholesterol modified form of the Shh protein), we demonstrate that N-Shh is sufficient to rescue most of the early embryonic lethal defects in a Disp1-null mutant background. Thus, Disp1 activity is only required for paracrine hedgehog protein signaling by the cholesterol modified form of Shh (N-Shhp), the normal product generated by auto-processing of a Shh precursor protein. In both respects, Disp function is conserved from Drosophila to mice.
INCREASED TAX DISCLOSURES AND CORPORATE TAX AVOIDANCE

This paper examines whether three recent mandatory tax disclosure regimes (Schedule M-3, FIN 48, and Schedule UTP) are associated with long-term changes in corporate tax avoidance. We find that both the Schedule M-3 and Schedule UTP disclosure regimes are associated with increased levels of tax avoidance while the FIN 48 disclosure regime is associated with decreased levels of tax avoidance. We also posit that these associations could differ for domestic and multinational firms because of the specific information required within each disclosure. We find that the increased tax avoidance associated with Schedule M-3 and Schedule UTP is stronger for domestic firms than for multinational firms. The decreased tax avoidance associated with FIN 48 is also stronger for domestic firms than for multinational firms.
Claudin‐1 immunohistochemistry for distinguishing malignant from benign epithelial lesions of prostate

Claudins are a family of approximately 23 integral membrane tight junction (TJ) proteins that maintain cell polarity and paracellular barrier functions in epithelial and endothelial cells. Although Claudin‐1 was demonstrated to be typically downregulated in various cancers, the precise expression patterns of this protein in normal and neoplastic tissues remain poorly characterized.
Treatment of experimental foreign body infection caused by methicillin-resistant Staphylococcus aureus

A novel model of experimental foreign body infection was developed in rats: four perforated Teflon tissue cages per animal were implanted subcutaneously and 3 to 4 weeks later were infected with 0.5 x 10(5) to 2 x 10(5) CFU of methicillin-resistant Staphylococcus aureus. After 2 weeks, the number of CFU in the cage fluid was determined [day 1 mean, (7.25 +/- 0.79) log10 CFU/ml], and treatment with vancomycin (50 mg/kg twice a day [BID]), fleroxacin (50 mg/kg BID), or fifampin (25 mg/kg BID), alone and in combination, was initiated for a duration of 6 days. Concentrations of antibiotics in cage fluids were in the range of those encountered in clinical conditions. Eighteen hours after the last injection (day 7), the number of CFU in the cage fluid was determined and the difference between day 1 and day 7 values was calculated. Rifampin, alone and in combination with fleroxacin or vancomycin, was the most effective regimen in reducing the bacterial counts in the tissue cage fluids [(1.87 +/- 1.44, 2.18 +/- 1.02, and 2.55 +/- 1.09 log10) CFU/ml, P less than 0.001, respectively]. After treatment, cage fluids and cages were analyzed for resistant bacteria. Resistance to rifampin occurred in 15 of 19 cages in animals treated with rifampin alone and in 4 of 25 in animals treated with rifampin plus vancomycin. We detected no development of resistance to rifampin in animals treated with rifampin plus fleroxacin or to fleroxacin in animals treated with this antimicrobial agent. In conclusion, regimens including rifampin alone or in combination with vancomycin or fleroxacin were an effective treatment of foreign body infection due to methicillin-resistant S. aureus in reducing bacteria counts, but rifampin monotherapy was compromised by significant emergence of resistance. The combined therapy of fleroxacin with rifampin prevent development of resistance to rifampin.
Inhibition of Trophoblast Cell Invasion by TGFB1, 2, and 3 Is Associated with a Decrease in Active Proteases1

Abstract Invasion of extravillous trophoblast cells into the uterus in human pregnancy is tightly regulated. The transforming growth factor-beta (TGFB) family has been suggested to play a role in controlling this process. We hypothesized that TGFB1, 2, and 3 would inhibit the invasive capacity of extravillous trophoblast cells. We also studied trophoblast apoptosis and proliferation and secreted protease levels as potential mechanisms by which these cytokines may act. Inhibition of endogenous TGFB1, 2, and 3 with neutralizing antibodies increased the invasive capacity of extravillous trophoblast cells derived from placental explants. Similarly, addition of exogenous TGFB1, 2, and 3 inhibited the invasive capacity of these cells in a dose-dependent manner. Proliferation of trophoblast in the placental explants did not alter in response to any of the cytokines tested. Apoptosis of villous and extravillous trophoblast did not alter in response to TGFB1, 2, and 3. There was a reduction in secreted levels of matrix metalloproteinase (MMP) 9 and urokinase plasminogen activator in response to all three cytokines. MMP2 and tissue inhibitor of metalloproteinase 1 and 3 levels were not altered. These results suggest that TGFB1, 2, and 3 inhibit trophoblast invasion by a mechanism dependent on reduced protease activity.
Discriminating patterns and drivers of multiscale movement in herpetofauna: The dynamic and changing environment of the Mojave desert tortoise

Abstract Changes to animal movement in response to human‐induced changes to the environment are of growing concern in conservation. Most research on this problem has focused on terrestrial endotherms, but changes to herpetofaunal movement are also of concern given their limited dispersal abilities and specialized thermophysiological requirements. Animals in the desert region of the southwestern United States are faced with environmental alterations driven by development (e.g., solar energy facilities) and climate change. Here, we study the movement ecology of a desert species of conservation concern, the Mojave desert tortoise (Gopherus agassizii). We collected weekly encounter locations of marked desert tortoises during the active (nonhibernation) seasons in 2013–2015, and used those data to discriminate movements among activity centers from those within them. We then modeled the probability of movement among activity centers using a suite of covariates describing characteristics of tortoises, natural and anthropogenic landscape features, vegetation, and weather. Multimodel inference indicated greatest support for a model that included individual tortoise characteristics, landscape features, and weather. After controlling for season, date, age, and sex, we found that desert tortoises were more likely to move among activity centers when they were further from minor roads and in the vicinity of barrier fencing; we also found that movement between activity centers was more common during periods of greater rainfall and during periods where cooler temperatures coincided with lower rainfall. Our findings indicate that landscape alterations and climate change both have the potential to impact movements by desert tortoises during the active season. This study provides an important baseline against which we can detect future changes in tortoise movement behavior.
Long-term effectiveness and tolerability of vagal nerve stimulation in adults with intractable epilepsy: a retrospective analysis of 100 patients

Abstract Data for 100 vagal nerve stimulation (VNS) patients were collected and analysed retrospectively. The mean seizure reduction was 17.86% (n = 67) at 6 months, 26.21% (n = 63) at 1 year, 30.43% (n = 53) at 2 years, 48.10% (n = 40) at 3 years, 49.44% (n = 32) at 4 years, 50.52% (n = 35) at 5 years, 45.85% (n = 31) at 6 years, 62.68% (n = 25) at 8 years, 76.41% (n = 9) at 10 years, 82.90% (n = 4) at 12 years. Evidence of statistical significance for mean seizure reduction over time was strong with all p values less than 0.05 except at 12 years (p = 0.125) where the sample size was small (n = 4). Mean seizure reduction was 49.04% and 51 (51%) patients were considered responders, defined as a 50% or more reduction in seizure frequency. Twenty-one (21%) patients suffered surgical complications. Of these 15 patients were self-limiting and 6 patients were irreversible or required a device revision. Fifty patients (50%) suffered from side-effects, while vagal stimulation cycled on (VNS on) post-operatively. However, of these, only one patient suffered from intolerable side effects requiring the device to be switched off temporarily. This study demonstrates the long-term efficacy in seizure reduction with the use of VNS. Complication rates and tolerability did not deviate greatly from that previously reported, indicating that VNS is a safe and effective treatment for seizure reduction in intractable epilepsy.
Inhibition of shear-induced platelet aggregation in rat by tetramethylpyrazine and salvianolic acid B.

Tetramethylpyrazine (TMP) and salvianolic acid B (SAB) are effective ingredients of Rhizoma Ligustici chuanxiong Hort. and Radix Salviae miltiorrhizae Bge. , accordingly. The inhibitive effects of TMP, SAB and their combination on shear-induced platelet aggregation (SIPA) were investigated in the present study. SD rats were used as blood donors to collect anticoagulated blood, the concentration of platelet-rich-plasma (PRP) was adjusted to 5 x 10(5) microl. HAAKE rheometer RS 600 with sensor C60/0.5 degrees was used as shear generator. Different doses of TMP and SAB and their combinations were added to the PRP. After constant shear of 15 Pa at 37 degrees C for 360 seconds, PRP was transferred to a platelet aggregometer and SIPA was determined by turbidity. SIPA was inhibited by TMP and SAB in a dose-dependent manner. SIPA was decreased from 48.6 +/- 4.6% of the control to 12.5 +/- 2.1% in the presence of TMP (1.46 mM) and SAB (10 microM) (P < 0.0001). In conclusion, TMP and SAB have additive effects on inhibiting platelet aggregation induced by high shear stress.
Effects of dietary phytase on performance and nutrient metabolism in chickens

1. A broiler growth study was conducted to compare the effect of different concentrations of an Escherichia coli-derived phytase on performance, apparent metabolisable energy (AME), nitrogen (N), amino acid and mineral metabolisability, sialic acid excretion and villus morphology when fed to broiler chickens. 2. Female Ross 308 broilers (480) were reared in floor pens from 0 to 28 d of age. All birds were fed on nutritionally complete starter (0 to 21 d of age) and grower diets (21 to 28 d of age) with the exception that they were low in P (28 and 23 g/kg available P, respectively). These maize–soy diets were supplemented with 0, 250, 500 or 2500 phytase units (FTU)/kg feed. 3. Between 21 and 28 d of age, two birds from each floor pen were selected, and each pair placed in one of 32 metabolism cages (two birds per cage). Feed intake was recorded and excreta collected for the last 2 d of the feeding period, and AME, N, amino acid and mineral metabolisability coefficients and endogenous losses were determined following a total collection procedure. 4. Feed intake and weight gain increased in a linear manner in response to phytase dose, with an average increase of approximately 11·7 and 13·5%, respectively, compared with chickens fed on the low-P diet. Birds given diets with 2500 FTU weighed 6·6% more and had a 2·4% higher feed conversion efficiency (FCE) than those fed on diets containing 500 FTU. 5. Enzyme supplementation increased the intake of AME and metabolisable N by 10·3 and 3·9%, respectively, principally through increases in feed intake. Birds given enzyme-supplemented diets also improved their intake of metabolisable amino acids and P by approximately 14 and 12·4%, respectively, compared with birds fed on the control diet. Enzyme supplementation did not affect ileal villus morphometry of the birds. †Dr O. Oduguwa is visiting scientist from University of Agriculture, PMB 2240, Abeokuta, Nigeria.
[Indication for removal of tibial nails].

BACKGROUND Tibial nail removal has been suggested as a routine procedure for both symptomatic and asymptomatic patients. The aim of this study was to define guidelines for the removal of tibial nails. PATIENTS AND METHODS A retrospective study on the isolated removal of 69 tibial nails after fracture consolidation was done. A review of the patient charts and radiographs was performed. Forty-four patients (64%) were available for the follow-up interview. RESULTS Preoperatively, 26 patients (59%) had local complaints. Of these 26 patients, 73% reported an improvement, and 8% reported an aggravation of their local complaints. Of the 18 patients who were asymptomatic before surgery, 17% reported long-term complaints at follow-up. CONCLUSION We conclude that routine removal of tibial nails should be discussed critically in asymptomatic patients.
Serum levels of collagenase, stromelysin-1, and TIMP-1. Age- and sex-related differences in normal subjects and relationship to the extent of joint involvement and serum levels of antigenic keratan sulfate in patients with osteoarthritis.

OBJECTIVE To measure serum levels of collagenase (MMP-1), stromelysin-1 (MMP-3), and tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) in normal subjects and in patients with osteoarthritis (OA), and to assess how these correlate with biochemical and clinical indicators of disease activity in OA. METHODS Specific immunoassays were used to measure MMPs, TIMP-1, and antigenic keratan sulfate (KS). The total area of cartilage affected by the disease was measured (expressed as an articular index). RESULTS In the normal population (n = 118), the serum concentration of MMP-3, but not of MMP-1 or TIMP-1, increased with age and was approximately 2 times higher in males than in females. In the OA patients (n = 33), the serum levels of MMP-3, but not of MMP-1 or TIMP-1, were significantly elevated and correlated strongly with the articular index but poorly with objective and subjective functional capacity scores as well as with serum levels of antigenic KS and systemic parameters of inflammation. CONCLUSION These findings illustrate the importance of matching patients and normal controls for age and sex in further studies of MMP-3 and are consistent with the hypothesis that MMP-3 might play an important role in the degradation of joint cartilage in OA. Further, serum levels of MMP-3 may prove useful for monitoring therapy for OA.
Is fiscal expansion more effective in a financial crisis?

ABSTRACT After the Great Recession, the Keynesian expansionary policy has been regarded as an effective measure, especially under imperfect financial market conditions. Among literature related to fiscal policy in financial crises, Fernández-Villaverde (2010) suggests that the fiscal policy multiplier increases in a financial crisis through the Fisher effect. However, we should note that the author simply compared the multiplier computed in the standard new Keynesian dynamic stochastic general equilibrium (DSGE) with that in the DSGE with financial accelerator settings. As the financial accelerator is considered effective during both financial crises and normal financial conditions, the author’s comparison should be considered insignificant for showing a greater multiplier in the financial crisis. In this study, to make the exact comparison, we first estimate parameters regarding the Fisher effect under each regime separately and then compute and compare the estimated fiscal multipliers using these 2 estimates in the same DSGE model. Using Japanese financial data that provide enough observations under the good and bad regimes of financial conditions, we find that fiscal multipliers are smaller in the bad regime than in the good regime.
2,2′-[2,3,5,6-Tetramethyl-p-phenylenebis(methylenethio)]bis(pyridine N-oxide)

Molecules of the title compound, C22H24N2O2S2, lie across centres of inversion. The two thiopyridine N-oxide groups adopt a stepped trans configuration with respect to the benzene ring, by virtue of the symmetry. The oxopyridinium ring forms a dihedral angle of 79.9 (2)° with the benzene ring. The crystal structure is stabilized by a strong π–π interaction between the pyridinium rings of adjacent molecules [ring centroid–centroid distance = 3.464 (3) Å].