Miracle-dz/UniFAR-FTUs huggingface dataset:
Do HR Practices Influence Job Satisfaction? Examining the Mediating Role of Employee Engagement in Indian Public Sector Undertakings

There is a dearth of research examining relationship among HR practices, employee engagement and job satisfaction in public sector undertakings in India. The present study makes an attempt to shed light on this largely neglected area of research by examining the mediating function of employee engagement between HR practices and job satisfaction. Data were collected from 393 executives through a questionnaire survey. Structural equation modelling was used to examine the relationship between HR practices, employee engagement and job satisfaction. HR practices were found to be positively linked with job satisfaction. Further, employee engagement significantly mediated the relationship between HR practices and job satisfaction. The practical implications of the study are discussed in the light of the existing literature.
Phosphorylation of tau at serine 416 by Ca2+/calmodulin‐dependent protein kinase II in neuronal soma in brain

It is well known that tau is a good in vitro substrate for Ca2+/calmodulin‐dependent protein kinase II (CaM kinase II). However, it is not clear at present whether CaM kinase II phosphorylates tau in vivo or not. Serine 416, numbered according to the longest human tau isoform, has been reported to be one of the major phosphorylation sites by CaM kinase II in vitro. In this study, we produced a specific antibody against tau phosphorylated at serine 416 (PS416‐tau). Immunoblot analysis revealed that the antibody reacted with tau in the rat brain extract which was prepared in the presence of protein phosphatase inhibitors. Developmental study indicated that serine 416 was strongly phosphorylated at early developmental stages in rat brain. We examined the localization of PS416‐tau in primary cultured hippocampal neurons and the immortalized GnRH neurons (GT1‐7 cells), which were stably transfected with CaM kinase IIα cDNA. Immunostaining of these cells indicated that tau was phosphorylated mainly in neuronal soma. Interestingly, tau in neuronal soma in Alzheimer's disease (AD) brain was strongly immunostained by the antibody. These results suggest that CaM kinase II is involved in the accumulation of tau in neuronal soma in AD brain.
Associations among Sleep, Chronotype, Parental Monitoring, and Pubertal Development among German Adolescents

Individuals differ in their timing of sleep (e.g., bedtimes, rise times) and in their preference for morning or evening hours. Chronotype refers to these differences in morningness—eveningness. Adolescents become later chronotypes during puberty, and the transition occurs around the age of 12-14 years. The authors assessed this change among German adolescents using measurements for chronotype, pubertal development, and parental monitoring. Chronotype and sleep parameters correlated significantly with age, suggesting that older adolescents become more evening oriented, sleep less, and have later rise and bedtimes. The authors obtained similar results when assessing puberty scores. Parental setting of bedtimes during the week decreased with age, and it was nearly absent at the age of 17 years. Adolescents without parental monitoring went to bed later and were later chronotypes. Using linear regressions, the authors found that age was the only significant predictor of chronotype, whereas age, pubertal status, and parental monitoring significantly contributed to bedtime during the week and sleep length on weekdays.
Intravitreal Dexamethasone in the Management of Acute Endophthalmitis: A Comparative Retrospective Study

Purpose To compare the clinical outcome of eyes with acute bacterial endophthalmitis treated with intravitreal injection of antibiotics with or without intravitreal dexamethasone. Methods This was a retrospective chart review of 63 eyes diagnosed with acute bacterial endophthalmitis and treated with vitreous tap and intravitreal injection of antibiotics, 19 eyes (30.2%) with and 44 eyes (69.8%) without concurrent intravitreal dexamethasone. Results Visual acuity had significantly improved by 1 week and was maintained long-term (p<0.001). There were no differences in visual outcome or rates of ocular complications between the groups. None of the eyes treated with dexamethasone required repeated intravitreal antibiotic injection while 6 (13.6 %) of the other eyes required repeated intravitreal antibiotic injection (p = 0.09). A subset analysis of 21 eyes that presented with light perception/no light perception vision where vitrectomy was not possible demonstrated that intravitreal antibiotic injection improved vision and achieved similar visual gain as in eyes that presented with hand motion vision or better, with no higher complication rates. Conclusions No adverse effect of intravitreal dexamethasone in the acute management of infectious endophthalmitis was noted. A trend toward less need for repeat intravitreal antibiotic therapy was noted in eyes with acute bacterial endophthalmitis treated with concurrent intravitreal dexamethasone at presentation.
Interobserver variation in the diagnosis of adenoma malignum (minimal deviation adenocarcinoma) of the uterine cervix

To examine the interobserver agreement level of the histological diagnosis of adenoma malignum (ADM), 52 proliferative endocervical glandular lesions were evaluated independently by four observers (A to D), each of whom is in charge of gynecological pathology at a different hospital. The correlation of diagnosis by each observer with patient outcome was also examined for 19 of these lesions. When the diagnoses were categorized into benign lesions including hyperplasias, ADM, and common types of adenocarcinoma, consistent diagnoses among all observers were achieved for only 12 lesions (23%), with a slight level of interobserver agreement (κ = 0.115). The points of disagreement were as follows: (i) whether proliferative endocervical glandular lesions preserving lobular structures were diagnosed as benign or as ADM; and (ii) whether proliferative endocervical glandular lesions with a discrete area of obvious adenocarcinoma were diagnosed as ADM or as common‐type adenocarcinoma. The mortality rates of patients with ADM diagnosed by observers A, B, C, and D were 60% (3 of 5), 25% (3 of 12), 14% (1 of 7), and 13% (2 of 15), respectively. Therefore, ADM diagnosed by observers A and B was frequently lethal, whereas ADM diagnosed by observers C and D was mostly non‐lethal and might contain benign lesions. The diagnosis of ADM covered various spectra of proliferative endocervical glandular lesions among the observers. Disagreement in the diagnosis was suggested to derive largely from the absence of consensus criteria for differential diagnosis among benign hyperplastic lesions, ADM, and common adenocarcinoma, and from differences in the observers’ interpretations about cellular atypia and invasion.
[Effects of beta-sitosterol on microtubular systems in cervical cancer cells].

OBJECTIVE To investigate beta-sitosterol's inhibitory effects on SiHa cells' growth, and the effects on microtubular system in SiHa cell. METHODS Proliferation inhibition of SiHa cell line was evaluated by MTT assay. Cell cycle of SiHa cells treated with beta-sitosterol was analyzed by flow cytometry. The expression and distribution of microtubule and microtubule associated protein 2 in SiHa cells were investigated by confocal microscopy. Immunoblotting analysis was used to determine tubulin alpha, microtubule associated protein 2, and the proportion of polymerization of tubulin. RESULTS beta-sitosterol could obviously inhibit the proliferation of SiHa cells, and induce the accumulation of cells in S phase (rather than the G2/M phase) and mitotic arrest in the cell cycle. Confocal microscopy showed an abnormal microtubular network in SiHa cell treated with beta-sitosterol for 5 days, and the expression of microtubule associated protein 2 was marked down-regulated. Further analysis by immunoblotting confirmed the down-regulation of beta-sitosterol on the expression for both microtubule associated protein 2 and tubulin alpha. Moreover, beta-sitosterol reduced the proportion of polymerization of microtubule in a time-dependent manner. CONCLUSION beta-sitosterol could down-regulate the expression of tubulin alpha and microtubule associated protein 2 in SiHa cells, and inhibit the microtubular polymerization. Our results suggested an anti-microtubule characteristic of beta-sitosterol which might contribute to the proliferation inhibition of SiHa cells.
Hemodialysis causes changes in dynamic vectorcardiographic ischemia monitoring parameters.

AIMS The aim of this study was to establish whether changes in parameters reflecting myocardial ischemia QRS vector difference (QRS-VD), ST change vector magnitude (STC-VM) and ST vector magnitude (ST-VM6) during hemodialysis (HD) registered by MIDA (myocardial infarction dynamic analysis) are related to changes in blood volume (BV), extracellular water (ECW) and blood biochemistry. PATIENTS AND METHODS Fifteen hemodialysis (HD) patients were studied. Computerized vectorcardiography was used for on-line dynamic analysis of ST segment and QRS complex changes. BV changes were monitored non-invasively and continuously with the CRIT-LINE instrument. Bioelectric impedance analysis (BIA) was used for ECW estimation. Blood samples were taken before and after hemodialysis for hemoglobin (B-Hb), hematocrit (B-Hcr), sodium (P-Na), chloride (P-Cl), magnesium (P-Mg), potassium (P-K), ionized calcium (P-iCa), phosphate (P-Pi) and astrup measurement. RESULTS During dialysis treatment QRS-VD, ST-VM6 and STC-VM did not change in parallel. According to the linear mixed model, no statistically significant changes were noted in ST-VM6 during dialysis (time effect p = 0.5635). On the other hand, QRS-VD and STC-VM showed a statistically significant linear trend (time effect for QRS-VD p = 0.0001 and for STC-VM p = 0.0004). Changes in both ECW and BV affected the change in QRS-VD and in STC-VM. CONCLUSION During HD treatment changes in the vectorcardiographic ischemia monitoring parameters QRS-VD and STC-VM are mostly related to ECW and BV changes and may give a false positive impression of myocardial ischemia. The ST-VM6 trend is less markedly influenced by volume changes.
The effect of blood contamination on the compressive strength and surface microstructure of mineral trioxide aggregate.

AIM To investigate the effects of whole, fresh human blood contamination on compressive strength and surface microstructure of grey and tooth-coloured mineral trioxide aggregate (MTA). METHODOLOGY The materials investigated were grey ProRoot MTA Original (Dentsply Tulsa Dental, Johnson City, TN, USA) and tooth-coloured ProRoot MTA (Dentsply Tulsa Dental). Three groups of 10 custom-made cylindrical moulds (internal dimensions 6 +/- 0.1 mm length and 4 +/- 0.1 mm diameter) were filled with tooth-coloured MTA. In the control group, MTA was mixed with water and exposed to water. In the second group, MTA was mixed with water and exposed to whole, fresh human blood. In the third group, MTA was mixed with and exposed to whole, fresh human blood. These three groups were then duplicated using grey MTA, creating a total of 60 samples. A predetermined amount of MTA and appropriate liquid were triturated in a plastic mixing capsule then subjected to ultrasonic energy after placement in the moulds. After 4 days of incubation, specimens were subjected to compressive strength testing. The surface microstructure of one extra specimen in each group was examined using scanning electron microscopy. Data were subjected to a two-way anova. RESULTS Regardless of MTA type, the mean compressive strength values of both experimental groups, which were in contact with blood, were significantly less than that of the control groups (P < 0.0001). In experimental groups in which MTA was mixed with water and exposed to blood, there was a significant difference (P < 0.0001) in compressive strength between tooth-coloured MTA (30.37 +/- 10.16 MPa) and grey MTA (13.92 +/- 3.80 MPa). CONCLUSION When blood becomes incorporated into MTA, its compressive strength is reduced. In clinical situations in which blood becomes mixed with MTA, its physical properties are likely to be compromised.
Agenda setting in the world of online news: New questions for new environment

This paper explores whether agenda setting theory is a fruitful approach to understand online news communication. To answer this question, the distinction between vertical and horizontal media is used and applied to online communication in order to establish their role in news circulation. Vertical media are defined as news media targeting the whole population, while horizontal media are those that enable horizontal flow of communication among different subjects, including citizens. The role these two types of media play in setting issue and attribute agenda is discussed. Additionally, their interconnection is considered in the context of constructing media agenda. Despite the fact that online communication flow is complex and goes in different directions, this paper marks horizontal media as a significant force in making community issue agenda and in interpreting attribute agenda set by vertical media. At the same time, vertical online news media are speculated to be still the major factor when it comes to public issue agenda, the agenda that is specific medium of connection for one society. This paper is trying to provide theoretical framework for thinking about agenda setting and to stimulate further empirical research that will shed additional light on the process.
Layer III Neurons Control Synchronized Waves in the Immature Cerebral Cortex

Correlated spiking activity prevails in immature cortical networks and is believed to contribute to neuronal circuit maturation; however, its spatiotemporal organization is not fully understood. Using wide-field calcium imaging from acute whole-brain slices of rat pups on postnatal days 1–6, we found that correlated spikes were initiated in the anterior part of the lateral entorhinal cortex and propagated anteriorly to the frontal cortex and posteriorly to the medial entorhinal cortex, forming traveling waves that engaged almost the entire cortex. The waves were blocked by ionotropic glutamatergic receptor antagonists but not by GABAergic receptor antagonists. During wave events, glutamatergic and GABAergic synaptic inputs were balanced and induced UP state-like depolarization. Magnified monitoring with cellular resolution revealed that the layer III neurons were first activated when the waves were initiated. Consistent with this finding, layer III contained a larger number of neurons that were autonomously active, even under a blockade of synaptic transmission. During wave propagation, the layer III neurons constituted a leading front of the wave. The waves did not enter the parasubiculum; however, in some cases, they were reflected at the parasubicular border and propagated back in the opposite direction. During this reflection process, the layer III neurons in the medial entorhinal cortex maintained persistent activity. Thus, our data emphasize the role of layer III in early network behaviors and provide insight into the circuit mechanisms through which cerebral cortical networks maturate.
Medium Frequency Cycles, Global Imbalances, and the Puzzles of Open Economy Macroeconomics.

This paper examines the ability of the endogenous growth and medium frequency cycle model of Holden (2016) to explain global imbalances and the puzzles of open economy macroeconomics. The model features complete international financial markets, and intrinsically multi-national R&D, yet is still able to get persistent movements in country-specific variables, including positive correlation between prices and consumption following some shocks. Key to the model’s mechanism is the complementarity between capital (including human capital) and embodied technology, which captures the necessity of investment and training before new technologies may be adopted. The crucial role played by capital in the model’s transmission mechanism gives an important role to financial disturbances and financial frictions, which we model in an original parsimonious form. We also introduce a novel production function that allows for short run non-unitary elasticities of substitution, while being consistent with balanced growth even when factors grow at differing rates.
NADPH Oxidase and PKC Contribute to Increased Na Transport by the Thick Ascending Limb During Type 1 Diabetes

—Type 1 diabetes triggers protein kinase C (PKC)-dependent NADPH oxidase activation in the renal medullary thick ascending limb (mTAL), resulting in accelerated superoxide production. As acute exposure to superoxide stimulates NaCl transport by the mTAL, we hypothesized that diabetes increases mTAL Na+ transport through PKC-dependent and NADPH oxidase–dependent mechanisms. An O2-sensitive fluoroprobe was used to measure O2 consumption by mTALs from rats with streptozotocin-induced diabetes and sham rats. In sham mTALs, total O2 consumption was evident as a 0.34±0.03 U change in normalized relative fluorescence (&Dgr;NRF)/min per mg protein. Ouabain (2 mmol/L) reduced O2 consumption by 69±4% and 500 &mgr;mol/L furosemide reduced O2 consumption by 58±8%. Total O2 consumption was accelerated in mTAL from diabetic rats (0.74±0.07 &Dgr;NRF/min/mg protein; P<0.05 versus sham), reflecting increases in ouabain- and furosemide-sensitive O2 consumption. NADPH oxidase inhibition (100 &mgr;mol/L apocynin) reduced furosemide-sensitive O2 consumption by mTAL from diabetic rats to values not different from sham. The PKC inhibitor calphostin C (1 &mgr;mol/L) or the PKC&agr;/&bgr; inhibitor Gö6976 (1 &mgr;mol/L) decreased furosemide-sensitive O2 consumption in both groups, achieving values that did not differ between sham and diabetic. PKC&bgr; inhibition had no effect in either group. Similar inhibitory patterns were evident with regard to ouabain-sensitive O2 consumption. We conclude that NADPH oxidase and PKC (primarily PKC&agr;) contribute to an increase in O2 consumption by the mTAL during type 1 diabetes through effects on the ouabain-sensitive Na+-K+-ATPase and furosemide-sensitive Na+-K+-2Cl− cotransporter that are primarily responsible for active transport Na+ reabsorption by this nephron segment.
A STUDY OF PREVALENCE OF HYPERTENSION AMONG BUS DRIVERS IN BANGALORE CITY

Background: Growing evidence suggests that hypertension is an important public health problem worldwide that constitutes the basis for the cardiovascular disease epidemic. Hypertension has become significant major health problem because of the major changes in the lifestyles, aging population, urbanization and socioeconomic changes. The percentage increases when selected occupational groups are screened. Transport drivers are one such group of people who are at risk of developing hypertension due to nature of their profession. The related impacts are not only harmful for driver’s health, but also may endanger others. Very few studies in this regard prompted to take up the present study. Objectives: To study the prevalence of hypertension among the city bus drivers and study its association with certain risk factors. Methods: A structured personal interview using questionnaire and physical examination which includes height weight and blood pressure recordings were done in 500 bus drivers who were enrolled to this cross sectional study Results: The prevalence of hypertension among the bus drivers was 16% (80/500). A significant positive correlation was seen between hypertension and increasing age, tobacco chewing and BMI. However, in this study hypertension was not found to be significantly associated with smoking, alcohol consumption, diet and salt intake. Conclusion: Considering the high prevalence of hypertension in bus drivers and its association with risk factors, necessary education programme to raise the awareness has to be conducted. The findings of this study should be reconfirmed by other large scale studies to identify the role of known and unknown factors in hypertension in this community.
Clinical Features and Treatment Outcomes of Non-Hodgkin’s Lymphomas Involving Rare Extranodal Sites: A Single-Center Experience

Background: The involvement of certain organs such as the adrenal gland and ovaries is rare in non-Hodgkin’s lymphoma (NHL). There are few studies comparing clinical features and prognosis based on the extranodal organ involved. Methods: We selected patients presenting with predominantly extranodal involvement among patients diagnosed with NHL from 1998 to 2009 at the Samsung Medical Center. Results: Forty-eight patients with NHL involving rare extranodal sites were analyzed. The extranodal sites were as follows: adrenal gland (n = 14), ovary (n = 13), pancreas (n = 11), uterus (n = 4), esophagus (n = 4) and prostate (n = 2). Diffuse large B-cell lymphoma (DLBCL) was the most common (n = 39), and the median overall survival (OS) was 16.63 months. There was no significant difference in OS according to the involved sites. Rituximab plus CHOP failed to provide an additive survival benefit over CHOP alone in 39 DLBCL patients. The OS of DLBCL in rare extranodal sites was worse than that in common sites when compared based on tumor stage. Conclusions: NHL involving rare extranodal sites had a poor prognosis, and the impact of rituximab on survival was negligible. Thus, more intensive therapeutic strategies should be considered for NHL involving rare extranodal sites.
Matgéné: a program to develop job-exposure matrices in the general population in France.

OBJECTIVES Matgéné is a program to develop job-exposure matrices (JEMs) adapted to the general population in France for the period since 1950. The aim is to create retrospective exposure assessment tools for estimating the prevalence of occupational exposure to various agents that can then be correlated to health-related parameters. METHODS JEMs were drawn up by a team of six industrial hygienists who based their assessments on available occupational measurement, economic and statistical data, and several thousand job descriptions from epidemiological studies performed in France since 1984. Each JEM is specific to one agent, assessing exposure for a set of homogeneous combinations (occupation × activity × period) according to two occupational classifications (ISCO 1968 and PCS 1994) and one economic activities classification (NAF 2000). The cells of the JEM carry an estimate of the probability and level of exposure. Level is estimated by the duration and intensity of exposure-linked tasks or by description of the tasks when exposure measurement data are lacking for the agent in question. The JEMs were applied to a representative sample of the French population in 2007, and prevalence for each exposure was estimated in various population groups. All documents and data are available on a dedicated website. RESULTS By the end of 2010, 18 JEMs have been developed and eight are under development, concerning a variety of chemical agents: organic and mineral dust, mineral fibers, and solvents. By implementation in the French population, exposure prevalences were calculated at different dates and for complete careers, and attributable risk fractions were estimated for certain pathologies. Some of these results were validated by comparison with those of other programs. DISCUSSION Initial Matgéné JEMs results are in agreement with the French and international literature, thus validating the methodology. Exposure estimates precision, however, vary between agents and according to the amount of exposure measurement data available. These JEMs are important epidemiological tools, and improving their quality will require investment in occupational health data harvesting, especially in the case of low-level exposures.