Miracle-dz/UniFAR-FTUs huggingface dataset:
Différenciation de cellules mésenchymateuses périnatales vers un phénotype musculaire lisse : base de la construction d'un feuillet vasculaire

Les pathologies vasculaires representent aujourd’hui l’une des principales causes de mortalite mondiale et leur nombre ne cesse d’augmenter. Les greffons autologues (disponibilite faible) et les protheses synthetiques inadaptees pour des vaisseaux de diametre inferieur a 6 mm ne repondent pas a la demande et il existe aujourd’hui, un reel besoin en substitut vasculaire pour les petits vaisseaux. Ainsi, le concept de l’ingenierie vasculaire semble tres prometteur. Cette approche est fondee sur l’utilisation de matrices « scaffold » associees a une composante cellulaire pour construire, dans des conditions environnementales adaptees, un vaisseau qui reponde et reagisse aux contraintes physiologiques. Dans cet objectif, la fonctionnalisation d’une media vasculaire constituee de cellules musculaires lisses (CML) est prerequise. Aux CML matures qui ne sont pas de bons candidats (perte de leur phenotype contractile lors de la culture), nous avons identifie les cellules souches mesenchymateuses (CSM) de la gelee de Wharton (tissu conjonctif du cordon ombilical) comme source cellulaire majeure. Leur facilite de recuperation, leur presence en grand nombre, leur faible immunogenicite et leur capacite de proliferation et differenciation en font d’excellents candidats en ingenierie tissulaire. Dans ce travail nous avons determine les conditions favorables a l’obtention d’un phenotype CML fonctionnelles et montre l’impact de differents parametres environnementaux (apport en oxygene, facteurs de croissance, teneur en serum…) sur le comportement des CSM de la gelee de Wharton. Nous avons pu montrer que 1) ces cellules etaient capables de se differencier en cellules au phenotype contractile comparable a celui des CML matures. 2) L’utilisation des films multicouches de polyelectrolytes (FMP) en tant que support d’adherence cellulaire a montre que les CSM de la gelee de Wharton avaient un comportement specifique selon la charge de surface conduisant vers une cultures tridimensionnelle inadaptee sur (PAH-PSS)3 PAH et en monocouche sur films (PAH-PSS)4, 3) Ces cellules pouvaient etre cultivees sur des hydrogels d’alginate fonctionnalises par les FMP pour fournir un feuillet cellulaire susceptible de recreer une media vasculaire.
Identifying Influential Users' Professions via the Microblogs They Forward

For most social media sites, how to ﬁnd out (inﬂuential) users’ pro-fessions is an important task. Much work has been conducted to explore this task through mining user-generated textual content or analyzing the social network structure. In this paper, we innovatively solve this task by only examining which microblog messages an inﬂuential user has forwarded. First, we deﬁne hot microblog messages under two standards and identify them from a large number of candidate messages. Each of the identiﬁed messages points to a speciﬁc hot event. Next, we group similar hot messages together based on their word similarity, semantic similarity, and forwarders’ similarity. Last, we represent users with the hot messages they forwarded and design an identiﬁcation method to identify their professions. Moreover, we collect a real-world dataset to conduct experiments and prove that our method performs signiﬁcantly better than the traditional method.
OUTCOME OF LYMPHEDEMA AFTER MICROSURGICAL TREATMENT

Lymphedema is a chronic disease with accumulation of water and proteins in the tissue, secondary to impairment of the lymphatic transport capacity. Nowadays, probably millions of persons worldwide are suffering from the disease. Lymphedema can be primary (congenital) or secondary (acquired after e.g. lymph node excision, radiotherapy, recurrent episodes of lymphangitis). The extremities are mostly affected although it can be present at every part of the body. Clinical parameters of lymphedema vary from swelling and recurrent infections (erysipelas) up to disability in end-stage disease because of inflammation and fibrosis in the affected limb. Although lymphedema is a chronic disease, the severity of the edema can be reduced by conservative treatment in many patients. The conservative approach comprises the association of manual lymph drainage, multilayer bandaging (short stretch bandages), physical exercises and skin care. Lifelong use of elastic stockings is mandatory. In patients that respond suboptimally to conservative treatment, one can find benefits associating surgical treatment. The aim of surgery in those cases is to reduce the size of the affected limb, to minimize recurrent episodes of lymphangitis and to improve limb function. A variety of surgical procedures have been applied. Currently, three types of surgical options exist. In reconstructive microsurgery, the interrupted lymphatic system is repaired by the interposition of a homologous vein or lymphatic collector 1,2. In contrast, derivative microsurgical procedures 3,4,5,6,7 aim to deviate the excess of lymphatic flow towards the venous system. A second type of surgery is the liposuction/lipectomy procedure 8 where the excess of fat accumulation after chronic THE EUROPEAN JOURNAL OF lymphology
Serum Parathyroid Hormone Concentrations in Patients with HIV Infection

Endocrine abnormalities are common in patients infected with the human immunodeficiency virus (HIV) but these rarely cause alterations in calcium homeostasis. 1 However, hypocalcaemia has been described in other acutely ill patients, including patients with infectious diseases. Following the diagnosis of frank hypoparathyroidism in a patient with symptomatic HIV infection, we have carried out a systematic study of serum parathyroid hormone (PTH) concentration in patients with symptomatic and asymptomatic HIV infection.
Efficient robust adaptive beamforming for cyclostationary signals

This paper deals with the problem of robust adaptive array beamforming for cyclostationary signals. By exploiting the signal cyclostationarity, the LS-SCORE algorithm presented in a paper by Agee et al. (1990) has been shown to be effective in performing adaptive beamforming without requiring the direction vector of the desired signal. However, this algorithm suffers from severe performance degradation even if there is a small mismatch in the cycle frequency of the desired signal. In this paper, we first evaluate the performance of the LS-SCORE algorithm in the presence of cycle frequency error (CFE). An analytical formula is derived to show the behavior of the performance degradation due to CFE. An efficient method is then developed based on the fact that the array output power approaches its maximum as the CFE is reduced. We formulate the problem as an optimization problem for reducing the CFE iteratively to achieve robust adaptive beamforming against the CFE. Simulation examples for confirming the theoretical analysis and showing the effectiveness of the proposed method are provided.
Naturally occurring mutation, Asp70His, in human butyrylcholinesterase

Background: People with genetic variants of butyrylcholinesterase can have hours of prolonged apnoea after a normal dose of succinylcholine or mivacurium. Methods Serum samples from 308 persons living in mid-USA were phenotyped to identify the atypical and fluoride variants. 308 samples were analysed for the K variant by DNA amplification, digestion with Mae III and gel electrophoresis. Amplified DNA from 16 samples was sequenced to identify the D70G, T243M and D70H mutations. Values for kcat and Km were determined for the D70H mutant BChE expressed in 293T cells. Results: A new mutation, Asp70His, was identified. This mutation is located in the peripheral anionic site of butyrylcholinesterase, where it causes a 10-fold decrease in binding affinity for positively charged substrates. Conclusion: People homozygous for the Asp70His mutation are expected to have prolonged apnoea in response to succinylcholine or mivacurium, similar to people with the Asp70Gly mutation.
Low power CMOS clock buffer

Modern high speed CMOS processors using on-chip phase-locked-loops often require a clock buffer with stringent specifications on the signal's rise time and fall time rather than on the buffer's delay time. For these applications, we propose a low power CMOS clock buffer that momentarily tri-states its output to minimize its power dissipation and its area requirement below those that are achievable by the traditional tapered CMOS buffers. <<ETX>>
Maternal Toxemia Is Associated With Reduced Incidence of Germinal Matrix Hemorrhage in Premature Babies

To evaluate prenatal and perinatal risk factors for development of germinal matrix hemorrhage-intraventricular hemorrhage (GMH-IVH), we conducted a prospective epidemiologic study of 449 babies whose birth weight was less than 1501 grams. This study permitted us to test our previously generated hypothesis that babies born to mothers with preeclampsia were at substantially reduced risk of developing GMH-IVH. Seventy-two (16%) of the babies in this population developed GMH-IVH. One (2.5%) of the 40 mothers with a diagnosis of preeclampsia and 71 (17.4%) of 409 mothers without preeclampsia gave birth to babies who developed GMH-IVH. GMH-IVH was seen in 6/107 (5.6%) of babies born to women with hypertension including 4/69 (5.8%) of babies born to women with pregnancy-induced hypertension, compared to 66/352 (18.8%) of babies born to mothers who did not have hypertension. Only 7.3% (8/108) of babies born to women who had proteinuria had GMH-IVH, compared to 18.3% (64/350) of babies whose mothers did not have proteinuria. GMH-IVH was seen in 5/89 (5.6%) of babies whose mothers had both hypertension and proteinuria, whereas 63/332 (19%) of babies born to mothers who lacked both factors, developed GMH-IVH. In stepwise logistic regression analysis, these significant findings were not explained by the presence of labor, postnatal acidemia, need for intubation, antenatal administration of steroids, birth weight, or gestational age. In addition, we found that maternal receipt of magnesium sulfate was associated with diminished risk of GMH-IVH even in those babies born to mothers who apparently did not have preeclampsia. We postulate that the association of preeclampsia and GVH-IVH may be related to prostaglandin effects. Reduced maternal, placental, and umbilical prostaglandin I2 (PGI2) values are characteristic of women with preeclampsia. Thus, babies born to mothers with preeclampsia may have a physiologic state similar to those having received indomethacin, a cyclooxygenase blocker that causes diminished PGI2 levels and an effective GMH-IVH prophylactic agent. We conclude that early third-trimester maternal preeclampsia/toxemia is associated with reduced risk of GMH-IVH in the preterm newborn. (J Child Neurol 1992;7:70-76).
Sequential Color LED Backlight Driving System for LCD Panels

In this paper, a sequential color light emitting diode (LED) backlight driving system for liquid crystal display (LCD) panels is proposed. Due to improvement on luminous efficacy, long life and wide color gamut, LED has gradually substituted for cold cathode fluorescent lamp as backlight. The proposed driving system adopts sequential color scanning scheme to improve light utilization efficiency by removing color filter. To meet display performance requirement that chromaticity variation Deltauv needs to be limited below 0.002, this paper also proposes a family of output current ripple free topologies to control the average driving current precisely, which in turn can reduce chromaticity variation. In addition, an LED bypass circuit is proposed to prevent LED arrays from open-circuit, and a driving voltage resetter is introduced to eliminate current spikes, improving backlight reliability and availability significantly. A forward-type output current ripple free converter has been built to sequentially drive color LED arrays, from which experimental measurements have verified the discussed performance and feasibility of the proposed system
Profile of Congenital Surgical Anomalies in Neonates Admitted to Tertiary Care Neonatal Intensive Care Unit of Saurashtra Region

Background: Congenital surgical anomaly is a major indication for admission of a neonate to an intensive care unit. Profile of surgical conditions is variable by system affecting the neonate and outcomes of the individual conditions depending upon treatment and post surgical facilities. This study was undertaken to highlight the surgical conditions, their burden and their prognosis encountered in our newborn care unit. Methodology: This study is a cross sectional study. All information was collected from the case records of all neonates admitted in newborn care unit of our centre between 1st April, 2011 and 31st October, 2014 with congenital surgical conditions and the following information extracted: surgical condition, age, sex, maturity, birth weight, its treatment and outcome, and other associated features were studied. Result: A total of 9213 neonates were admitted in the study period, of which 328 neonates (3.6%) had surgical conditions. Surgery was performed in 225 neonates. Commonest congenital surgical condition was of gastrointestinal tract (GIT). Commonest GIT anomalies were tracheo-oesophageal fistula (28.6%), intestinal obstruction (23.7%), anorectal malformation (17.9%), and omphalocoele (7%). The overall mortality in neonates with congenital surgical condition in this study was 51.2%. Significantly, more deaths occurred in preterm than in term neonates (P = 0.00003) and low birth weight babies more than normal weight (p=0.0002). Conclusion: High mortality is found in neonates suffering from surgical conditions. Commonest anomaly includes conditions of Gastrointestinal tract. Prematurity and low birth weight is a significant factor associated with high mortality.
Prediction of Fetal Growth Deviations by Use of Symphysis-Fundus Height Measurements

Abstract The development of various symphysis fundus (SF) growth charts and the use of SF height measurements in the diagnosis of small-for-gestational-age (SGA) births and the prediction of newborn complications are reviewed. Measurement precision and accuracy are also discussed. It is concluded that further research of this simple, low cost, harmless, and widespread technology to detect fetal growth disturbances in routine prenatal care is warranted.
Swimming kinematics and hydrodynamic imaging in the blind Mexican cave fish (Astyanax fasciatus)

SUMMARY Blind Mexican cave fish (Astyanax fasciatus) lack a functioning visual system, and are known to use self-generated water motion to sense their surroundings; an ability termed hydrodynamic imaging. Nearby objects distort the flow field created by the motion of the fish. These flow distortions are sensed by the mechanosensory lateral line. Here we used image processing to measure detailed kinematics, along with a new behavioural technique, to investigate the effectiveness of hydrodynamic imaging. In a head-on approach to a wall, fish reacted to avoid collision with the wall at an average distance of only 4.0±0.2 mm. Contrary to previous expectation, there was no significant correlation between the swimming velocity of the fish and the distance at which they reacted to the wall. Hydrodynamic imaging appeared to be most effective when the fish were gliding with their bodies held straight, with the proportion of approaches to the wall that resulted in collision increasing from 11% to 73% if the fish were beating their tails rather than gliding as they neared the wall. The swimming kinematics of the fish were significantly different when swimming beside a wall compared with when swimming away from any walls. Blind cave fish frequently touched walls when swimming alongside them, indicating that they use both tactile and hydrodynamic information in this situation. We conclude that although hydrodynamic imaging can provide effective collision avoidance, it is a short-range sense that may often be used synergistically with direct touch.
Tensor Detection Severely Constrains Axion Dark Matter

The recent detection of B modes by the BICEP2 experiment has nontrivial implications for axion dark matter implied by combining the tensor interpretation with isocurvature constraints from Planck observations. In this Letter the measurement is taken as fact, and its implications considered, though further experimental verification is required. In the simplest inflation models, r=0.2 implies HI=1.1×10(14) GeV. If the axion decay constant fa 1 accounts for theoretical uncertainty). If fa>HI/2π then vacuum fluctuations of the axion field place conflicting demands on axion DM: isocurvature constraints require a DM abundance which is too small to be reached when the backreaction of fluctuations is included. High-fa QCD axions are thus ruled out. Constraints on axionlike particles, as a function of their mass and DM fraction, are also considered. For heavy axions with ma≳10(-22) eV we find Ωa/Ωd≲10(-3), with stronger constraints on heavier axions. Lighter axions, however, are allowed and (inflationary) model-independent constraints from the CMB temperature power spectrum and large scale structure are stronger than those implied by tensor modes.
Enhanced Fatigue Resistance in Older Adults During Repeated Sets of Intermittent Contractions

Rawson, ES. Enhanced fatigue resistance in older adults during repeated sets of intermittent contractions. J Strength Cond Res 24(1): 251-256, 2010-Reportedly, muscle fatigue in older individuals is greater, less than, or similar to young individuals, potentially because of differences in muscle groups studied, type of contraction, continuous vs. intermittent contractions, exercise duration, duty cycle, and contraction speed. During a single set of isokinetic mode knee extensions, muscle fatigue is similar between older and younger individuals. However, repeated sets may favor the more oxidative nature of muscle from older adults and may be necessary to reveal age-associated enhanced fatigue resistance. The purpose of this investigation was to compare muscular fatigue induced by repeated sets of intermittent isokinetic mode knee extensions in older and younger males. Nineteen older (mean ± SD) (66 ± 6 yr) and 16 younger (21 ± 2 yr) men completed 5 sets of 30 isokinetic mode knee extensions at 180 degrees/second. In the analysis of absolute fatigue, both groups significantly decreased torque production during each set, with young men having significantly higher torque production during all 5 sets. Relative fatigue was significantly greater in young participants during sets 2 through 5 (old vs. young: set 2: 17.1 vs. 26.6%; set 3: 25.5 vs. 39.7%; set 4: 28.1 vs. 45.1%; set 5: 29.3 vs. 46.4%; overall relative fatigue: old 22.2%; young 38.1%). These data indicate enhanced fatigue resistance in older men, which was revealed using repeated sets of intermittent contractions. Resistance to muscle fatigue is only one component of healthy aging muscle, and perhaps exercise interventions targeted toward prevention of falls in the elderly should focus on improved muscle power rather than fatigability/sustainability of contractions.
Uso de fibra vegetal y cemento en la construcción de colmenas

El proposito de esta investigacion fue encontrar un material alternativo para la construccion de colmenas, a manera de prolongar su vida util, reducir costos y que cumpla un objetivo ecologico, utilizando para este proposito planchas de fibra vegetal y cemento, las cuales se utilizaron para construir colmenas tipo Langstroth. Se evaluaron dos tratamientos, (fibra vegetal + cemento y madera), habiendo constado cada uno de 9 repeticiones, siendo la unidad experimental una colmena. Se analizaron las variables siguientes: A) Aceptacion de las colmenas, B) Reproduccion en terminos de area de oviposicion de la reina y finalmente, C) Costos de fabricacion. En cuanto a la variable aceptacion, no hubo diferencias estadisticas (P< 0.05) entre ambos tratamientos, aceptandose, la hipotesis propuesta (Ho: P1 = P2) . La reproduccion presento diferencias significativas (P< 0.05) entre tratamientos, y como se propuso que Ho: M1 = M2; se rechaza la hipotesis planteada. Las colmenas de fibra vegetal y cemento, tuvieron un costo inicial mayor que las de madera, incrementandolo en Q 53.37; sin vegetal se estima en por lo menos el doble que la de madera, de esa cuenta, el costo anual del tratamiento “Madera” fue de Q 39.78, mientras que el costo anual del tratamiento “Fibra vegetal + cemento” fue de Q 27.82, lo expuesto indica claramente que existe una diferencia de Q 11.96, lo que representa menor costo para las colmenas fabricadas con fibra vegetal + cemento.
Investigation of Seepage Meter Measurements in Steady Flow and Wave Conditions

Water exchange between surface water and groundwater can modulate or generate ecologically important fluxes of solutes across the sediment‐water interface. Seepage meters can directly measure fluid flux, but mechanical resistance and surface water dynamics may lead to inaccurate measurements. Tank experiments were conducted to determine effects of mechanical resistance on measurement efficiency and occurrence of directional asymmetry that could lead to erroneous net flux measurements. Seepage meter efficiency was high (average of 93%) and consistent for inflow and outflow under steady flow conditions. Wave effects on seepage meter measurements were investigated in a wave flume. Seepage meter net flux measurements averaged 0.08 cm/h—greater than the expected net‐zero flux, but significantly less than theoretical wave‐driven unidirectional discharge or recharge. Calculations of unidirectional flux from pressure measurements (Darcy flux) and theory matched well for a ratio of wave length to water depth less than 5, but not when this ratio was greater. Both were higher than seepage meter measurements of unidirectional flux made with one‐way valves. Discharge averaged 23% greater than recharge in both seepage meter measurements and Darcy calculations of unidirectional flux. Removal of the collection bag reduced this net discharge. The presence of a seepage meter reduced the amplitude of pressure signals at the bed and resulted in a nearly uniform pressure distribution beneath the seepage meter. These results show that seepage meters may provide accurate measurements of both discharge and recharge under steady flow conditions and illustrate the potential measurement errors associated with dynamic wave environments.
Aedes vector population dynamics and occurrence of dengue fever in relation to climate variables in Puducherry, South India

Puducherry (previously Pondicherry) had reported regular dengue outbreaks since 2003 with increase in number of cases every year. The study was aimed to assess changes in the intensity of vector breeding and its reflection upon case occurrence in relation to climatic variables. Dengue vector surveys were carried out in six Primary Health Centres (PHCs) representing both rural and urban areas round the year, and entomological indices were determined using standard methods. Aedes aegypti and Ae. albopictus were the vectors encountered in the survey, and Ae. aegypti present in high numbers in urban as well as rural areas. For both species, the size of immature populations found to increase with increasing rainfall, though heavy rains resulted in population loss . A significant relationship was found between larval indices and rainfall. Diurnal temperature range was found a critical factor negatively associated with vector abundance (larval indices) and occurrence of dengue cases.