Miracle-dz/UniFAR-FTUs huggingface dataset:
Ins and outs modulating hepatic triglyceride and development of nonalcoholic fatty liver disease.

In conjunction with the expanding clinical interest in nonalcoholic fatty liver disease (NAFLD), there has been a rapid increase in experimental research to understand hepatic triglyceride homeostasis. Hepatic triglyceride content is modulated by factors affecting liver fatty acid uptake, synthesis and oxidation, and triglyceride secretion. Physiological and pharmacologic investigations in humans and animals, and genetic experiments (Table 1) like those reported in this issue have elucidated these pathways.
Clinical Consensus Statement Development Manual

Clinical consensus statements reflect opinions drafted by content experts for which consensus is sought using explicit methodology to identify areas of agreement and disagreement. In contrast to clinical practice guidelines, which are based primarily on high-level evidence, clinical consensus statements are more applicable to situations where evidence is limited or lacking, yet there are still opportunities to reduce uncertainty and improve quality of care. This manual describes methodology used by the American Academy of Otolaryngology—Head and Neck Surgery Foundation to promote rapid and consistent development of clinical consensus statements for its membership. Although the manual contains specific practices relevant to the Academy, the principles are also explained and may help other organizations create similar products.
Laser-Fluoride Effect on Root Demineralization

Although the individual cariostatic effects of laser and fluoride have been shown, the combined effect of CO2 laser and fluoride on root demineralization remains uncertain and was the main aim of this study. By using a pH-cycling system and Polarized Light Microscopy, we demonstrated the synergistic effect of fluoride combined with CO2 laser treatment on reducing root demineralization. The mean lesion depths (in μm) for each group were 160 ± 14 (Control), 113 ± 8 (Laser treatment alone), 111 ± 6 (Fluoride treatment alone), and 25 ± 7 (Fluoride followed by laser treatment). A significant laser-enhanced fluoride uptake, characterized by the ToF-SIMS analysis, was revealed by the 37% and 400% increments in loosely and firmly bound fluorides (both p < 0.002) in laser-irradiated areas, compared with the non-irradiated controls. In conclusion, there is a significant synergistic effect of combined CO2 laser and fluoride treatment on the inhibition of root demineralization, possibly due to laser-enhanced fluoride uptake in the root.
Antihypercholesterolemic Effects of Fruit Aqueous Extract of Copernicia prunifera (Miller) H. E. Moore in Mice Diet-Induced Hypercholesterolemia

The present objective of the investigation is to evaluate the antihypercholesterolemic activity of the aqueous fruit pulp extract (APE) of Copernicia prunifera (Miller) H. E. Moore (Arecaceae family). Various chemical characterization methods like thin layer chromatography, Fourier transform infrared spectroscopy, 1H and 13C NMR, and molecular weight by gel permeation chromatography have been employed to characterize the extracted pectin. The present study demonstrated that hypercholesterolemic diet (HD) created hypercholesterolemia, caused significant increases in body weight, total cholesterol, and low-density lipoprotein, and caused decreases in high-density lipoprotein in serum compared with SD group. Two doses (APE 150 and 300 mg/Kg b.w./day) were administered to hyperlipidemic mice for 90 days. APE reversed body weight changes, changed serum lipids to normal values, and significantly inhibited the changes of lipid peroxidation and inflammation in the liver tissues. The renal parameters analyzed (urea and creatinine) altered by diet were reverted to normal values. Our results revealed that aqueous fruit pulp extracts of carnauba reduced hypercholesterolemia showing a potential preventive effect against cardiovascular diseases without side effects cause.
HILS1 is a spermatid-specific linker histone H1-like protein implicated in chromatin remodeling during mammalian spermiogenesis

Chromatin remodeling is a major event that occurs during mammalian spermiogenesis, the process of spermatid maturation into spermatozoa. Nuclear condensation during spermiogenesis is accomplished by replacing somatic histones (linker histone H1 and core histones) and the testis-specific linker histone, H1t, with transition proteins and protamines. It has long been thought that H1t is the only testis-specific linker histone, and that all linker histones are replaced by transition proteins, and subsequently by protamines during spermiogenesis. Here, we report the identification and characterization of a spermatid-specific linker histone H1-like protein (termed HILS1) in the mouse and human. Both mouse and human HILS1 genes are located in intron 8 of the α-sarcoglycan genes. HILS1 is highly expressed in nuclei of elongating and elongated spermatids (steps 9-15). HILS1 displays several biochemical properties that are similar to those of linker histones, including the abilities to bind reconstituted mononucleosomes, produce a chromatosome stop during micrococcal nuclease digestion, and aggregate chromatin. Because HILS1 is expressed in late spermatids that do not contain core histones, HILS1 may participate in spermatid nuclear condensation through a mechanism distinct from that of linker histones. Because HILS1 also belongs to the large winged helix/forkhead protein superfamily, HILS1 may also regulate gene transcription, DNA repair, and/or other chromosome processes during mammalian spermiogenesis.
Running head : ADOLESCENT SELF-ESTEEM AND ADULT DEPRESSION Low and Decreasing Self-Esteem During Adolescence Predict Adult Depression Two Decades

Previous studies revealed that low self-esteem is prospectively associated with depression. However, self-esteem has been shown to change over time. We thus hypothesized that not only level but also change in self-esteem affect depression. Using data from a 23-year longitudinal study (N = 1,527), we therefore examined the prospective effects of global and domain-specific self-esteem (physical attractiveness, academic competence) level and change on depressive symptoms 2 decades later. Self-esteem was assessed annually from age 12 to 16, and depression was assessed at age 16 and 35. Results from latent growth curve analyses demonstrated that both level and change in self-esteem served as predictors for adult depression. Individuals who entered adolescence with low self-esteem, and/or whose self-esteem declined further during the adolescent years, were more likely to exhibit symptoms of depression 2 decades later as adults; this pattern held both for global and domain-specific self-esteem. These findings highlight the importance of adolescent self-esteem development for mental health outcomes in adulthood. DOI: https://doi.org/10.1037/a0035133 Posted at the Zurich Open Repository and Archive, University of Zurich ZORA URL: https://doi.org/10.5167/uzh-101336 Accepted Version Originally published at: grue, Andrea E; Allemand, Mathias; Robins, Richard W; Fend, Helmut A (2014). Low and decreasing self-esteem during adolescence predict adult depression two decades later. Journal of Personality and Social Psychology, 106(2):325-38. DOI: https://doi.org/10.1037/a0035133
Association of chromosomal regions 3p21.2, 10p13, and 16p13.3 with nonsyndromic cleft lip and palate

Approximately 4,000 babies with nonsyndromic cleft lip with or without cleft palate (NSCLP) are born each year in the United States. Because NSCLP exhibits both etiologic and genetic heterogeneity, attempts to identify the underlying genetic causes have met with limited success and the pursuit of early promising findings have yielded mixed results. Two recent genomic scans identified a number of suggestive regions; some of these results have been supported by our lab and others in subsequent studies. Using our NSCLP multiplex family population, we were able to provide additional supportive evidence for association to the regions 2q37, 11p12‐14, 12q13, and 16p13.11‐p12 that were identified in the genomic scans. However, there remains a number of additional viable candidate genes and regions that have not been sufficiently investigated. These include chromosomal translocations in patients with NSCLP, growth factor genes, metalloproteinase (MMP) and transcription factor (patterning) genes, including those in the WNT family. Here, we present results from screening the 10p13 chromosomal translocation region associated with NSCLP, MMP genes clustered on chromosomes 1p36, 11q22.3, 16p13.3, and 16q12‐13, and the region containing the WNT5A gene on chromosome 3p21. Markers from three of the regions, 10p13, 16p13.3 (MMP25), and 3p21.2, yielded findings that are sufficiently significant to warrant closer investigation. © 2003 Wiley‐Liss, Inc.
Imagery effects on the performance of skilled and novice soccer players.

The purpose of this study was to investigate the effect of an imagery training programme on the performance of a soccer task by skilled and novice players. An initial assessment of performance on the soccer task was undertaken, and then 22 skilled and 22 novice players were equally and randomly assigned to either a control or an experimental group. The experimental group was given an imagery training programme consisting of both visual and kinaesthetic imagery, and in which both internal and external imagery perspectives were included. The programme lasted 6 weeks, with the subjects attending bi-weekly sessions of approximately 15 min each. The control group developed a competitive strategy that was totally unrelated to the performance task. Similar to the experimental group, the controls did this over a 6-week period, attending bi-weekly sessions of 15 min duration. Two performance measures were recorded--response time (i.e. the time to complete the soccer task) and performance accuracy (i.e. errors in performing the soccer task recorded in the form of time penalties). Performance on the post-test as measured by response time revealed a significant improvement for both the skilled and novice players in the imagery group. The control group failed to show any such improvement. No effects were found for performance accuracy.
Exposure to music and cognitive performance: tests of children and adults

This article reports on two experiments of exposure to music and cognitive performance. In Experiment 1, Canadian undergraduates performed better on an IQ subtest (Symbol Search) after listening to an up-tempo piece of music composed by Mozart in comparison to a slow piece by Albinoni. The effect was evident, however, only when the two pieces also induced reliable differences in arousal and mood. In Experiment 2, Japanese 5-year-olds drew for longer periods of time after singing or hearing familiar children's songs than after hearing Mozart or Albinoni, and their drawings were judged by adults to be more creative, energetic, and technically proficient. These results indicate that (1) exposure to different types of music can enhance performance on a variety of cognitive tests, (2) these effects are mediated by changes in emotional state, and (3) the effects generalize across cultures and age groups.
Melanoma inhibitory activity, a biomarker related to chondrocyte anabolism, is reversibly suppressed by proinflammatory cytokines in rheumatoid arthritis

Objective: In mice, melanoma inhibitory activity (MIA) is a chondrocyte-specific molecule with similar regulation to collagen type II. As MIA is a small secreted protein, its value as cartilage biomarker in human inflammatory arthritis was assessed. Methods: MIA tissue distribution was studied by quantitative PCR and immunohistochemistry. The regulation of MIA production was studied in vivo in rheumatoid arthritis (RA) (n = 37) and spondyloarthritis (SpA) (n = 30) synovial fluid (SF), and in vitro in alginate embedded human chondrocytes. Therapeutic modulation of serum MIA was evaluated during tumour necrosis factor (TNF)α and interleukin (IL)1 blockade in RA. Results: MIA was primarily expressed by chondrocytes in the human joint. SF MIA levels were lower in RA than in SpA despite similar levels of overall synovial inflammation. Further analysis indicated that these levels were inversely correlated with the degree of joint inflammation in RA, but not in SpA, and that the levels of TNFα and IL1β were significantly increased in RA versus SpA. Accordingly, these proinflammatory cytokines suppressed MIA mRNA and protein in cultured chondrocytes. This suppression was paralleled by suppression of cartilage anabolism as assessed by collagen type 2 and aggrecan mRNA. Treatment of patients with RA with TNF blockade or IL1 blockade induced an increase of serum MIA levels. Conclusion: The decreased levels of MIA in the inflamed RA joint and the coregulation of MIA and cartilage matrix molecules by proinflammatory cytokines indicate that joint inflammation in RA not only drives accelerated cartilage degradation but also suppresses cartilage anabolism. This inflammation-driven suppression is reversible in vivo.
The Effect of Drop Jump Starting Height and Contact Time on Power, Work Performed, and Moment of Force

&NA; Walsh, M. , A. Arampatzis, F. Schade, and G. ‐P. Brüggemann. The effect of drop jump starting height and contact time on power, work performed, and moment of force. J. Strength Cond. Res. 18(3):561–566. 2004. —The purposes of this study are (a) to examine the effects of contact time manipulation on jump parameters and (b) to examine the interaction between starting height changes and contact time changes on important jump parameters. Fifteen male athletes performed a series of drop jumps from heights of 20, 40, and 60 cm. The instructions given to the subjects were (a) “jump as high as you can” and (b) “jump high a little faster than your previous jump. ” Jumps were performed at each height until the athlete could not achieve a shorter ground contact time. The data were divided into 5 groups where group 1 was made up of the longest ground contact times of each athlete and groups 2–4 were composed of progressively shorter contact times, with group 5 having the shortest contact times. The jumps of group 3 produced the highest maximum and mean mechanical power (p <0.05) during the positive phase of the drop jumps regardless of starting jump height. The vertical takeoff velocities for the first 3 groups did not show significant (p < 0.05) differences. These results indicate that the manipulation of jump technique plays larger role than jump height in the manipulation of important jump parameters.
IL-17 Suppresses Immune Effector Functions in Human Papillomavirus-Associated Epithelial Hyperplasia

Persistent infection with high-risk human papillomaviruses (HPV) causes epithelial hyperplasia that can progress to cancer and is thought to depend on immunosuppressive mechanisms that prevent viral clearance by the host. IL-17 is a cytokine with diverse functions in host defense and in the pathology of autoimmune disorders, chronic inflammatory diseases, and cancer. We analyzed biopsies from patients with HPV-associated cervical intraepithelial neoplasia grade 2/3 and murine skin displaying HPV16 E7 protein-induced epithelial hyperplasia, which closely models hyperplasia in chronic HPV lesions. Expression of IL-17 and IL-23, a major inducer of IL-17, was elevated in both human HPV-infected and murine E7-expressing lesions. Using a skin-grafting model, we demonstrated that IL-17 in HPV16 E7 transgenic skin grafts inhibited effective host immune responses against the graft. IL-17 was produced by CD3+ T cells, predominantly CD4+ T cells in human, and CD4+ and γδ T cells in mouse hyperplastic lesions. IL-23 and IL-1β, but not IL-18, induced IL-17 production in E7 transgenic skin. Together, these findings demonstrate an immunosuppressive role for IL-17 in HPV-associated epithelial hyperplasia and suggest that blocking IL-17 in persistent viral infection may promote antiviral immunity and prevent progression to cancer.
Investigating the Role of Time in Affective Forecasting: Temporal Influences on Forecasting Accuracy

Using extensive diary data from people taking their driver's license exam, the authors investigated the role of time in affective forecasting accuracy. Replicating existing findings, participants grossly overestimated the intensity and duration of their negative affect after failure and only slightly overestimated the intensity and duration of their positive affect after success. Extending existing findings, participants accurately predicted a decrease of their affective reactions over time but underestimated the speed with which this decrease would occur. In addition, they showed greater forecasting accuracy for positive affect than negative affect when the exam was distant and greater forecasting accuracy for negative affect than positive affect when the exam was close. The motivational processes underlying these findings are being discussed.
Immunohistochemical localization of S‐ 100 protein in granular cell myoblastoma

The presence and distribution of S‐100 protein were studied in three cases of granular cell myoblastoma using the peroxidase‐anti‐peroxidase method. Positive immunostaining was observed in all cases. The densely brown reaction products were found both in the nuclei and in the cytoplasm of myoblastoma cells. The staining of the nuclei was more intense than that of the cytoplasm. In addition, both normal Schwann cells and tumor cells of Schwannomas were also stained with anti‐S‐100 antibody. This result further supports the concept of the neurogenic origin of the granular cell myoblastoma.
Heterarchy of cognition: The depths and the highs of a framework for memory research

To celebrate the levels-of-processing approach, I describe a multilevel evolutionary architecture for human behaviour and cognition. New experimental data on human eye movements are presented that demonstrate a possibility of splitting visual perceptual activity at least on two hierarchical but closely interrelated levels of processing. Furthermore, data from behavioural studies of human memory and neuroimaging testify that within the domain of cognition proper two higher levels can be differentiated. I call them “conceptual structures” and “metacognitive coordinations” and provide evidence that the latter may residue in the phylogenetically new structures of prefrontal and particularly right prefrontal cortices. From this point of few, the most natural framework for an analysis of the levels-of-processing effects on human memory is to consider them as interactions within the main gradients of evolution and development of the corresponding neurophysiological mechanisms. Finally, several new, still unanswered questions for the future research are formulated.
Systemic inflammation and arrhythmic risk: lessons from rheumatoid arthritis

Rheumatoid arthritis (RA) is a chronic immuno-mediated disease primarily affecting the joints, characterized by persistent high-grade systemic inflammation. Cardiovascular morbidity and mortality are significantly increased in RA, with >50% of premature deaths attributable to cardiovascular disease. In particular, RA patients were twice as likely to experience sudden cardiac death compared with non-RA subjects, pointing to an increased propensity to develop malignant ventricular arrhythmias. Indeed, ventricular repolarization (QT interval) abnormalities and cardiovascular autonomic nervous system dysfunction, representing two well-recognized risk factors for life-threatening ventricular arrhythmias in the general population, are commonly observed in RA. Moreover, large population-based studies seem to indicate that also the prevalence of atrial fibrillation is significantly higher in RA subjects than in the general population, thus suggesting that these patients are characterized by an abnormal diffuse myocardial electrical instability. Although the underlying mechanisms accounting for the pro-arrhythmogenic substrate in RA are probably intricate, the leading role seems to be played by chronic systemic inflammatory activation, able to promote arrhythmias both indirectly, by accelerating the development of ischaemic heart disease and congestive heart failure, and directly, by affecting cardiac electrophysiology. In this integrated mechanistic view, lowering the inflammatory burden through an increasingly tight control of disease activity may represent the most effective intervention to reduce arrhythmic risk in these patients. Intriguingly, these considerations could be more generally applicable to all the diseases characterized by chronic systemic inflammation, and could help elucidate the link between low-grade chronic inflammation and arrhythmic risk in the general population.
Can High-Tech Ventures Benefit from Government Guanxi and Business Guanxi? The Moderating Effects of Environmental Turbulence

The construct of guanxi has become an interesting topic for analyzing how to do business more effectively and successfully in China’s economic transition period. Drawing on the guanxi strategy theory, this study examines when government guanxi ( guanxi with the government and its officials) and business guanxi ( guanxi with the business sectors) matter to new venture performance under two typical turbulent environments (institutional turbulence and market turbulence). According to empirical results using original data from 146 new ventures in clusters driven by China’s local governments, both government guanxi and business guanxi were positively related to new venture performance, and market turbulence was an important contextual factor influencing performance benefits of guanxi . However, the results reveal no moderating effects of institutional turbulence on direct relationships. Furthermore, the study provides a better conceptual and empirical understanding of why market turbulence is a double-edged sword for performance implications of guanxi in the rapidly changing business environment.