Miracle-dz/UniFAR-FTUs huggingface dataset:
Acute Static Vibration-Induced Stretching Enhanced Muscle Viscoelasticity But Did Not Affect Maximal Voluntary Contractions in Footballers

Abstract Jemni, M, Mkaouer, B, Marina, M, Asllani, A, and Sands, WA. Acute static vibration-induced stretching enhanced muscle viscoelasticity but did not affect maximal voluntary contractions in footballers. J Strength Cond Res 28(11): 3105–3114, 2014—The aim of this study was to compare the effects of acute vibration-enhanced static stretching and/or static stretching alone on the strength and flexibility of the hamstrings and quadriceps muscles. Twenty-one male footballers participated in this study (21.9 ± 1.8 years; 75.54 ± 7.3 kg; 178.7 ± 6.5 cm). The experiment started with 5 minutes standardized warm-up followed by (a) baseline flexibility pretest (Split Test); (b) maximal voluntary flexion and extension (isokinetic strength) of the knee; (c) Treatment or Sham involving 45-second stretch with or without vibration for the hamstring and quadriceps muscle groups with 10-second rest between; and (d) posttest repeating the measures of the pretest. Each player randomly performed both trials on separate occasions. The vibration device operated at 35 Hz with 2 mm amplitude. Stretching with vibration statistically increased hamstring flexibility by 7.8% (p ⩽ 0.05) when compared with stretching without vibration. No statistical differences for hamstring or quadriceps strength were noted between treatment conditions. There was no statistical correlation between flexibility and strength measurements. In conclusion, flexibility increased with vibration-enhanced static stretching; however, no change was evident in the maximal voluntary contractions of the knee flexors and extensors.
Paraoxonase 2 attenuates macrophage triglyceride accumulation via inhibition of diacylglycerol acyltransferase 1 Published, JLR Papers in Press, December 16, 2008.

This study questioned the role of paraoxonase 2 (PON2) in attenuation of macrophage lipids accumulation. Mouse peritoneal macrophages (MPMs) harvested from PON2-deficient mice versus control C57BL/6 mice, look like foam cells and were larger in size and filled with lipid droplets. Macrophage triglyceride (but not cholesterol) content, biosynthesis rate, and microsomal acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) activity (not mRNA and protein) in PON2-deficient versus control MPM were all significantly increased by 4.6-, 3.6-, and 4.4-fold, respectively. Similarly, microsomal DGAT1 activity and cellular triglyceride content were significantly decreased in human PON2-transfected cells as well as upon incubation of PON2-deficient MPM with recombinant PON2. In all the above experimental systems, PON2 also decreased macrophage oxidative state. Incubation of PON2-deficient MPM with the free radicals generator 2,2′-amidinopropane hydrochloride increased cellular oxidative stress and DGAT1 activity by 2.2- and 3.4-fold, respectively, whereas incubation of microsomes from PON2-deficient MPM with superoxide dismutase decreased DGAT1 activity by 40%. We thus conclude that PON2 attenuates macrophage triglyceride accumulation and foam cell formation via inhibition of microsomal DGAT1 activity, which appears to be sensitive to oxidative state.
Does the Accruals Quality Premium Arise from Information Risk?

In this study, we examine whether the accruals quality premium arises from information risk through the following: (i) an investigation of the accruals quality (AQ) premium conditioned by market competition levels; (ii) a test of the impact of an exogenous shock on tax-loss-selling incentives; and (iii) an examination of the quality of specific accruals. Consistent with an information risk explanation, we find that the pricing effect of AQ is concentrated in firms with low market competition; that tax-loss selling is unlikely to explain the observed AQ premium; and that specific accruals quality measures which are more likely to reflect information risk are priced.
Nurse preceptor training needs assessment: views of preceptors and new graduate nurses.

BACKGROUND In Taiwan, regulatory bodies mandate that preceptor training programs comprise six mandatory topics used by all teaching hospitals. These programs have little empirical justification. This study explores the training needs of preceptors from the viewpoints of both preceptors and preceptees. METHOD Investigators used qualitative methods to conduct 17 focus group interviews with 63 preceptors and 24 preceptees from five hospitals in Taiwan. A constant comparative method was used to analyze the data and extract themes and subthemes from participants' experiences. RESULTS Seven themes were extracted from both preceptor teaching experiences and preceptee learning experiences. Analysis of the empirical data showed that the six mandated topics do not meet the needs of preceptors. This study also documented the concept of "nurses eating their young" for the first time in Taiwan. CONCLUSION The findings of this study may serve as a reference for redesigning preceptor training programs in Taiwan.
Melting trends over the Greenland ice sheet (1958–2009) from spaceborne microwave data and regional climate models

Abstract. To study near-surface melt changes over the Greenland ice sheet (GrIS) since 1979, melt extent estimates from two regional climate models were compared with those obtained from spaceborne microwave brightness temperatures using two different remote sensing algorithms. The results from the two models were consistent with those obtained with the remote sensing algorithms at both daily and yearly time scales, encouraging the use of the models for analyzing melting trends before the satellite era (1958–1979), when forcing data is available. Differences between satellite-derived and model-simulated results still occur and are used here to identify (i) biases in the snow models (notably in the albedo parametrization, in the thickness of a snow layer, in the maximum liquid water content within the snowpack and in the snowfall impacting the bare ice appearance in summer) and (ii) limitations in the use of passive microwave data for snowmelt detection at the edge of the ice sheet due to mixed pixel effect (e.g., tundra or rock nearby the ice sheet). The results from models and spaceborne microwave sensors confirm a significant (p-value = 0.01) increase in GrIS surface melting since 1979. The melt extent recorded over the last years (1998, 2003, 2005 and 2007) is unprecedented in the last 50 yr with the cumulated melt area in the 2000's being, on the average, twice that of the 1980's.
Quark mass RG-running for $N_f$ =3 QCD in a $\chi SF$ setup

We compute the nonperturbative quark mass RG-running in the range $\Lambda_{QCD}\lessapprox\mu\lessapprox M_W$ for $N_f=3$ massless QCD with a mixed action approach: sea quarks are regularised using nonperturbatively $O(a)$-improved Wilson fermions with Schr\"odinger functional (SF) boundary conditions, employing the configurations of 1802.05243, while valence quarks are regularised using nonperturbatively $O(a)$-improved Wilson fermions with chirally rotated Schr\"odinger functional boundary conditions ($\chi$SF). Our result is compatible with its SF counterpart of ref.1802.05243, confirming the universality of $\chi$SF and SF in the continuum limit. We also establish the optimal tuning strategy for the critical hopping parameter $\kappa_c$ and the $\chi$SF boundary counterterm coefficient $z_{\rm f}$. We work in two energy regimes with two different definitions of the coupling: SF-coupling for 2 GeV $\lessapprox\mu\lessapprox M_W$ and GF-coupling for $\Lambda_{QCD} \lessapprox\mu\lessapprox 2 GeV$.
Cocaine actions on rat prefrontal cortical and hippocampal dentate granule neurons in vitro

The electrophysiological actions of cocaine hydrochloride (COC) on medial prefrontal cortical (mpfc) and hippocampal dentate granule (DG) neurons were investigated in rat brain slices with intracellular recording techniques. The following parameters were measured: resting membrane potential (RMP), spike threshold, spike firing adaptation, postspike train afterhyperpolarization (AHP), excitatory postsynaptic potentials (EPSPs), and inhibitory postsynaptic potentials (IPSPs). In the mpfc, COC appeared to have both inhibitory and excitatory effects. In the majority of cells examined, the EPSP amplitude was attenuated by COC (200 nM–20 μM), whereas the amplitude of the postspike train afterhyperpolarization (AHP) was reduced (an excitatory effect). In DG neurons, 1 μM COC caused a small depolarization. COC potentiated the EPSPs at 1 μM but attenuated EPSPs and IPSPs at 10–100 μM. The amplitude of antidromically evoked EPSPs was also increased by 20 μM COC. At concentrations of 10 μM and greater, COC increased spike threshold. It is concluded that COC actions on mpfc and DG neurons are both excitatory and inhibitory and that these effects may be mediated by multiple neurotransmitters/modulators. © 1993 Wiley‐Liss, Inc.
MRI of muscular fat

An MRI technique with high selectivity and sensitivity to the signal components in the chemical shift range of methylene and methyl protons of fatty acids has been developed for noninvasive assessment of muscular fat in vivo. A spoiled gradient‐echo sequence with spatial‐spectral excitation by six equidistant pulses with 2°‐(−9°)‐17°‐(−17°)‐9°‐(−2°) and a multi‐echo train (TE = 16, 36, 56, 76, 96, and 116 ms) allowed a series of images to be recorded with a receiver bandwidth of 78 Hz per pixel. SIs from phantoms with lipid contents between 0.1% and 100% were compared to those from pure water. Thirty healthy volunteers underwent fat‐selective imaging of their lower leg, and parallel localized proton spectroscopy of the tibialis anterior and the soleus muscle by a single‐voxel stimulated echo acquisition mode (STEAM) technique (TR = 2 s, TE = 10 ms, TM = 15 ms). Results show a high correlation (r = 0.91) between fat imaging and the spectroscopic approach in the soleus muscle, considering the percentage total fat content of musculature. The correlation coefficient was clearly lower (r = 0.55) in the tibialis anterior muscle due to signal contaminations from adjacent subcutaneous fat in the images, inhomogeneous fat distribution, and generally lower lipid content in this muscle. Applications of the new imaging technique showed marked intra‐ and interindividual variability in the spatial distribution of lipids in the musculature of the lower leg. No significant correlation of the muscular fat with the thickness of the subcutaneous fat layer was found. In addition, the body mass index does not appear to determine muscular fat content, except in very obese cases. Magn Reson Med 47:720–727, 2002. © 2002 Wiley‐Liss, Inc.
Alzheimer disease in the United States (2010–2050) estimated using the 2010 census

Objectives: To provide updated estimates of Alzheimer disease (AD) dementia prevalence in the United States from 2010 through 2050. Methods: Probabilities of AD dementia incidence were calculated from a longitudinal, population-based study including substantial numbers of both black and white participants. Incidence probabilities for single year of age, race, and level of education were calculated using weighted logistic regression and AD dementia diagnosis from 2,577 detailed clinical evaluations of 1,913 people obtained from stratified random samples of previously disease-free individuals in a population of 10,800. These were combined with US mortality, education, and new US Census Bureau estimates of current and future population to estimate current and future numbers of people with AD dementia in the United States. Results: We estimated that in 2010, there were 4.7 million individuals aged 65 years or older with AD dementia (95% confidence interval [CI] = 4.0–5.5). Of these, 0.7 million (95% CI = 0.4–0.9) were between 65 and 74 years, 2.3 million were between 75 and 84 years (95% CI = 1.7–2.9), and 1.8 million were 85 years or older (95% CI = 1.4–2.2). The total number of people with AD dementia in 2050 is projected to be 13.8 million, with 7.0 million aged 85 years or older. Conclusion: The number of people in the United States with AD dementia will increase dramatically in the next 40 years unless preventive measures are developed.
The Stafford outbreak of Legionnaires’ disease

SUMMARY A large outbreak of Legionnaires’ disease was associated with Stafford District General Hospital. A total of 68 confirmed cases was treated in hospital and 22 of these patients died. A further 35 patients, 14 of whom were treated at home, were suspected cases of Legionnaires’ disease. All these patients had visited the hospital during April 1985. Epidemiological investigations demonstrated that there had been a high risk of acquiring the disease in the out patient department (OPD), but no risk in other parts of the hospital. The epidemic strain of Legionella pneumophila, serogroup 1, subgroup Pontiac la was isolated from the cooling water system of one of the air conditioning plants. This plant served several departments of the hospital including the OPD. The water in the cooling tower and a chiller unit which cooled the air entering the OPD were contaminated with legionellae. Bacteriological and engineering investigations showed how the chiller unit could have been contaminated and how an aerosol containing legionellae could have been generated in the U–trap below the chiller unit. These results, together with the epidemiological evidence, suggest that the chiller unit was most likely to have been the major source of the outbreak. Nearly one third of hospital staff had legionella antibodies. These staff were likely to have worked in areas of the hospital ventilated by the contaminated air conditioning plant, but not necessarily the OPD. There was evidence that a small proportion of these staff had a mild legionellosis and that these ‘influenza–like’ illnesses had been spread over a 5–month period. A possible explanation of this finding is that small amounts of aerosol from cooling tower sources could have entered the air–intake and been distributed throughout the areas of the hospital served by this ventilation system. Legionellae, subsequently found to be of the epidemic strain, had been found in the cooling tower pond in November 1984 and thus it is possible that staff were exposed to low doses of contaminated aerosol over several months. Control measures are described, but it was later apparent that the outbreak had ended before these interventions were introduced. The investigations revealed faults in the design of the ventilation system.
Seeding, Referral, and Recommendation

In recent years, word-of-mouth (WOM) marketing has been the subject of considerable interest among managers and academics alike. However, there is very little common knowledge on what drives the value of WOM programs and how they should be designed to optimize value. Firms therefore frequently rely on relatively simple metrics to measure the success of their WOM marketing efforts and mainly use rules of thumb when making crucial program design decisions. This article proposes a new method to measure WOM program value that is based on the impact of WOM on the firm’s customer equity. It then provides recommendations for the five main questions managers face when planning a WOM program: Who to target? When to launch the program? Where to launch it? Which incentives to offer? and How many participants to include?
Non-supersymmetric black holes with ' corrections pdfkeywords=black hole, string theory, entropy, temperature, Wald, Hawking, branes, supergravity, supersymmetry, corrections, WGC, weak gravity conjecture, heterotic superstring

We study extremal 5and 4-dimensional black hole solutions of the Heterotic Superstring effective action at first order in α′ with, respectively, 3 and 4 charges of arbitrary signs. For a particular choice of the relative signs of these charges the solutions are supersymmetric, but other signs give rise to non-supersymmetric extremal black holes. Although at zeroth order all these solutions are formally identical, we show that the α′ corrections are drastically different depending on how we break supersymmetry. We provide fully analytic O(α′) solutions and we compute their charges, masses and entropies and check that they are invariant under α′-corrected T-duality transformations. The masses of some of these black holes are corrected in a complicated way, but we show that the shift is always negative, in agreement with the Weak Gravity Conjecture. Our formula for the corrected entropy of the four-dimensional black holes generalizes previous results obtained from the entropy function method, as we consider a more general way in which supersymmetry can be broken. aEmail: pabloantonio.cano[at]kuleuven.be bEmail: tomas.ortin[at]csic.es cEmail: alejandro.ruiperez[at]pd.infn. it dEmail: matteo.zatti[at]estudiante.uam. es ar X iv :2 11 1. 15 57 9v 1 [ he pth ] 3 0 N ov 2 02 1
Bovine tuberculosis (Mycobacterium bovis) in British farmland wildlife: the importance to agriculture

Bovine tuberculosis (bTB) is an important disease of cattle and an emerging infectious disease of humans. Cow- and badger-based control strategies have failed to eradicate bTB from the British cattle herd, and the incidence is rising by about 18% per year. The annual cost to taxpayers in Britain is currently £74 million. Research has focused on the badger as a potential bTB reservoir, with little attention being paid to other mammals common on farmland. We have conducted a systematic survey of wild mammals (n=4393 individuals) present on dairy farms to explore the role of species other than badgers in the epidemiology of bTB. Cultures were prepared from 10 397 samples (primarily faeces, urine and tracheal aspirates). One of the 1307 bank voles (Clethrionomys glareolus) live-sampled, and three of the 43 badgers (Meles meles), yielded positive isolates of Mycobacterium bovis. This is the first time the bacterium has been isolated from the bank vole. The strain type was the same as that found in cattle and badgers on the same farm. However, our work indicates that the mean prevalence of infectious individuals among common farmland wildlife is extremely low (the upper 95% confidence interval is ≤2.0 for all of the abundant species). Mathematical models illustrate that it is highly unlikely the disease could be maintained at such low levels. Our results suggest that these animals are relatively unimportant as reservoirs of bTB, having insufficient within-species (or within-group) transmission to sustain the infection, though occasional spill-overs from cattle or badgers may occur.
Microarray analysis of gene expression in murine skin exposed to sulfur mustard

The chemical warfare agent sulfur mustard [bis‐(2‐chloroethyl)‐sulfide; SM] produces a delayed inflammatory response followed by blister formation in skin of exposed individuals. Studies are underway evaluating the efficacy of pharmacological compounds to protect against SM skin injury. Microarray analysis provides the opportunity to identify multiple transcriptional biomarkers associated with SM exposure. This study examined SM‐induced changes in gene expression in skin from mice cutaneously exposed to SM using cDNA microarrays. Ear skin from five mice, paired as SM‐exposed right ear and dichloromethane vehicle‐exposed left ear at six dose levels (0.005, 0.01, 0.02, 0.04, 0.08, and 0.16 mg; 6 mM to 195 mM range), was harvested at 24 h post‐exposure. SM‐induced gene expression was analyzed using cDNA microarrays that included 1,176 genes. Genes were selected on the basis of all mice (N = 5) in the same dose group demonstrating a ≥2‐fold increase or decrease in gene expression for the SM‐exposed tissue compared to the dichloromethane vehicle control ear tissue at all six SM doses. When skin exposed to all six concentrations of SM was compared to controls, a total of 19 genes within apoptosis, transcription factors, cell cycle, inflammation, and oncogenes and tumor suppressors categories were found to be upregulated; no genes were observed to be downregulated. Differences in the number and category of genes that were up‐ or down‐regulated in skin exposed to low (0.005–0.01 mg) and high (0.08–0.16 mg) doses of SM were also observed. The results of this study provide a further understanding of the molecular responses to cutaneous SM exposure, and enable the identification of potential diagnostic markers and therapeutic targets for treating SM injury. © 2005 Wiley Periodicals, Inc. J Biochem Mol Toxicol 18:289–299, 2004; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jbt.20043
Developmental flexibility and the effect of social environment on fertility and fecundity in parthenogenetic reproduction

SUMMARY One specialized environment that can influence development arises in the context of social interactions, including the environment contributed by a sexual partner during sexual reproduction. It is often difficult, however, to separate out the effect of mating (fertilization) from the effect of social environment. In the study reported here we examine the effect of social environment mediated by a pheromonal signal on the fertility and fecundity of the facultatively parthenogenetic cockroach Nauphoeta cinerea. By examining parthenogenetically reproducing females, we isolate the effects of social environment in the absence of mating or fertilization. Females exposed to male odors are more likely to produce parthenogenetic offspring. Further, increased exposure to the male pheromone increases the number of offspring produced. Variation in timing of reproduction is also dependent on the male. Thus, social environments are a mechanism by which males contribute to the development of their offspring, resulting in variation in development. This study illustrates the potential evolutionary importance of social environments in development, because a requirement for male‐contributed environments may be a constraint to evolving asexual reproduction from a sexually reproducing species.
Whose Realm, His Trust - Regional Disparities of Generalized Trust in Europe

Trust explains the functioning of markets, institutions or society as a whole. It is a key element in almost every commercial transaction over time and might be one of the main explanations of economic success and development. In Europe, the determinants of (generalized) trust have been investigated in the past. Most scholars have focused on aggregate (national) levels of trust. However, it can be assumed that driving forces, which foster or diminish trust, act at a sub-national level. Regional clusters remain undetected. With the use of the European Social Survey 6 and modern spatial diagnostics, this work examines the individual and regional determinants of trust in 88 European NUTS1 regions in 26 countries. There are two main findings. First, wealth, linguistic fragmentation, and religious ideologies shape trust on a regional level, education, income, and membership in associations foster trust on an individual level. Secondly, the study unravels regional dispersions in different types of "trust regimes" in Europe. Regional clusters of generalized trust are confirmed by spatial diagnostics. The "regionality" of trust could be of importance for future targeted policy making.