Miracle-dz/UniFAR-FTUs huggingface dataset:
Abdominal Obesity Indicators: Waist Circumference or Waist-to-hip Ratio in Malaysian Adults Population

Background: Waist circumference (WC) is an accurate and simple measure of abdominal obesity as compared to waist–hip ratio (WHR). The aim of this study was to determine the correlation between body mass index (BMI) with WC and WHR and suggest cutoff points for WC among Rural Malaysian adults. Methods: A cross-sectional study was conducted among 669 respondents from three villages in Tanjung Karang, located in the district of Kuala Selangor. Data collection was carried out by guided questionnaires and anthropometric measures. Results: The prevalence of abdominal obesity for BMI was almost similar for both gender across Caucasian and Asian BMI cutoff points. Based on Caucasian cutoff points, the prevalence of abdominal obesity for WC was 23.8% (male) and 66.4% (female) while for WHR was 6.2% (male) and 54.2% (female). Asian cutoff points gave higher prevalence of abdominal obesity compared to that of WC among male respondents and WHR for both genders. WC showed strong and positive correlation with BMI compared to WHR (in male WC r = 0.78, WHR r = 0.24 and in female WC r = 0.72, WHR r = 0.19; P < 0.001). Receiver operating characteristic curve analysis suggested WC cutoff points of 92.5 cm in men and 85.5 cm in women is the optimal number for detection of abdominal obesity. Conclusions: WC is the best indicator as compared with WHR for abdominal obesity for Malaysian adults.
Inflammatory myopathies: management of steroid resistance.

PURPOSE OF REVIEW The inflammatory myopathies include polymyositis, dermatomyositis, necrotizing autoimmune myopathy (NAM), and inclusion body myositis (IBM). On the basis of clinical experience, most patients respond to corticosterioids to some degree or for a time period. For patients insufficiently responding or for steroid-sparing, the treatment options vary among practitioners, generating a genuine uncertainty. This timely review highlights emerging new therapies and provides practical therapeutic algorithms. RECENT FINDINGS For patients insufficiently responding to corticosteroids, the commonly used immunosuppressants, such as azathioprine, mycophenolate, methotrexate, or cyclosporine, may exert a nonevidence-based 'steroid-sparing' effect but provide minimal benefit on their own. The second line therapy is intravenous immunoglobulin (IVIg) based on a controlled study conducted in dermatomyositis; the drug is also effective in many patients with polymyositis and NAM. Rituximab and tacrolimus may offer additional benefit. Anti-TNF agents are disappointing. IBM remains difficult to treat; although early on some patients may partially respond to steroids or IVIg, they soon become unresponsive and the disease progresses. Emerging agents against T cells, B cells, and transmigration molecules are discussed as promising therapeutic options. SUMMARY New biological agents are in the offing for control trials. Appropriate outcome measures are however needed to assess and monitor responses.
Thermodynamics of protein destabilization in live cells

Significance A key question in structural biology is how protein properties mapped out under simplified conditions in vitro transfer to the complex environment in live cells. The answer, it appears, varies. Defying predictions from steric crowding effects, experimental data have shown that cells in some cases stabilize and in other cases destabilize the native protein structures. In this study, we reconcile these seemingly conflicting results by showing that the in-cell effect on protein thermodynamics is sequence specific: The outcome depends both on the individual target protein and on its detailed host-cell environment. Although protein folding and stability have been well explored under simplified conditions in vitro, it is yet unclear how these basic self-organization events are modulated by the crowded interior of live cells. To find out, we use here in-cell NMR to follow at atomic resolution the thermal unfolding of a β-barrel protein inside mammalian and bacterial cells. Challenging the view from in vitro crowding effects, we find that the cells destabilize the protein at 37 °C but with a conspicuous twist: While the melting temperature goes down the cold unfolding moves into the physiological regime, coupled to an augmented heat-capacity change. The effect seems induced by transient, sequence-specific, interactions with the cellular components, acting preferentially on the unfolded ensemble. This points to a model where the in vivo influence on protein behavior is case specific, determined by the individual protein’s interplay with the functionally optimized “interaction landscape” of the cellular interior.
Sources and Sinks of Escherichia coli in Benthic and Pelagic Fish

ABSTRACT Escherichia coli and fecal coliform bacteria were isolated from five benthic and four pelagic fish species to determine their role in the fecal contamination of recreational waters. All fish were collected during fall 2006 from Southworth Marsh in the Duluth-Superior Harbor, a public beach that is commonly posted to minimize water contact due to high E. coli levels. Although fecal coliform bacteria were isolated from each fish species, they were only isolated from 66% and 72% of the individual benthic and pelagic fish, respectively. While 42% of the fecal coliforms from benthic fish were E. coli, only 4% of these bacteria from pelagic fish were E. coli. Cluster analysis showed different fish species harbored identical strains of E. coli and some fish contained multiple E. coli strains. The potential source for 65% of the E. coli isolates obtained from fish were identified by using the HFERP DNA fingerprinting method and libraries of E. coli DNA fingerprints from warm-blooded animals and environmental isolates collected in the area. The E. coli strains whose source could be identified were most similar to strains isolated from sediments, Canada geese, mallard ducks, and wastewater. None of the fish E. coli had DNA fingerprints matching those from any water or beach sand isolates. Although our results demonstrate that benthic fish contain E. coli, it may be more appropriate to consider these fish as a vector of E. coli from other sources, rather than a new source of E. coli contamination in aquatic environments.
Information privacy compliance in the healthcare industry

Purpose – The Health Insurance Portability and Accountability Act (HIPAA) is US legislation aimed at protecting patient information privacy, but it imposes a significant burden on healthcare employees, especially since the privacy provisions are still evolving and healthcare organizations are still struggling to meet compliance criteria. This study seeks to illuminate characteristics of both the environment (organization) and the individual (healthcare professional) and their relevant influence on compliance intentions by leveraging theories from the domains of social psychology, management, and information systems.Design/methodology/approach – A study of 208 healthcare professionals located at healthcare facilities throughout the USA were surveyed as to their perceptions regarding HIPAA compliance and the underlying organizational and individual factors that influence said compliance.Findings – The findings indicate that perceptions of organizational support and self‐efficacy (SE) leading to HIPAA compli.
Ultrasonographic renal changes associated with phenylbutazone administration in three foals.

Dhenylbutazone is a nonsteroidal anti-inflammatory drug widely used in horses and rapidly absorbed following oral administration (1). Renal papillary or medullary crest necrosis has been noted as an adverse reaction with various daily doses of phenylbutazone in clinical and experimental studies (2-6). This report describes the ultrasonographic renal changes that developed with high daily doses of phenylbutazone in 3 clinically normal, neonatal foals, and correlates these changes with histopathological findings. Three orphan, clinically normal, 7to 10-day-old foals (2 males, 1 female) were used in a study of a scintigraphic technique to detect gastric ulcers. The protocol was approved by The Ohio State University Institutional Laboratory Animal Care and Use Committee. Before we administered the phenylbutazone, we ascertained through physical examination, clinical history, complete blood counts, and blood chemistry panels that the foals were normal. Each foal received phenylbutazone at a dosage of 5 mg/kg body weight (BW), PO, ql2h for 7 d. The foals were examined every day for clinical signs of gastrointestinal and renal abnormalities. A complete blood count and a blood chemistry panel were performed on d 7. Ultrasonographs were performed before phenylbutazone administration and before euthanasia, using 7.5 and 5 MHz transducers (Aloka 500V, Corometrics Company; ATL Ultramark 4, Advanced Technology Laboratory, Tempe, Arizona, USA). The caudodorsal paralumbar areas were clipped, with the foals in a standing position. The left kidney was imaged at the mid-ventral aspect of the left flank, caudal to the 18th rib, and the right kidney was imaged between the 17th and 18th ribs. The study was recorded on a videotape and, in addition, static images were obtained. The relative echogenicity among the liver, spleen, and kidneys, as well as any abnormalities, were recorded. The foals were euthanized and necropsied on d 8. Kidneys were collected and fixed in 10% buffered neutral formalin, and then stained with hematoxylin and eosin. The foals did not develop clinical signs indicative of gastrointestinal or renal abnormalities. The results of complete blood counts and blood chemistry panels remained within normal limits at the end of the treatment period. Ultrasonographic appearances of the kidneys were normal before the administration of phenylbutazone.
Symmetry Breaking in Star-Topology Decoupled Search

Symmetry breaking is a well-known method for search reduction. It identifies state-space symmetries prior to search, and prunes symmetric states during search. A recent proposal, star-topology decoupled search, is to search not in the state space, but in a factored version thereof, which avoids the multiplication of states across leaf components in an underlying star-topology structure. We show that, despite the much more complex structure of search states -- so-called decoupled states -- symmetry breaking can be brought to bear in this framework as well. Starting from the notion of structural symmetries over states, we identify a sub-class of such symmetries suitable for star-topology decoupled search, and we show how symmetries from that sub-class induce symmetry relations over decoupled states. We accordingly extend the routines required for search pruning and solution reconstruction. The resulting combined method can be exponentially better than both its components in theory, and this synergetic advantage is also manifested in practice: empirically, our method reliably inherits the best of its base components, and often outperforms them both.
COMPRATIVE ANTIMICROBIAL EFFICACY EVALUATION OF A NEW PRODUCT ELORES AGAINST MEROPENEM ON GRAM NEGATIVE ISOLATES

ABSTRACT Background and objective: Increased resistance of Gram-negative bacteria towards most of the available antibiotics, especially beta-lactam antibiotics is a prime difficulty for the treatment of infections caused by these pathogens. In view of the fact that there is a continuous increase in the antibitic resistance and the limited available therapeutic options, we aimed the present work to evaluate the antibiotic susceptibility pattern of 847 isolates towards meropenem and Elores (ceftriaxone+sulbcatam+and adjuvant ethylenediaminetetraacetic acid). Methods: A total of 1180 clinical samples were collected from patients suspected of bacterial infection between January 2014 to June 2014. These samples were subjected for bacterial identification. Antibiotic susceptibility testing were carried out according to the recommendations of Clinical Laboratory Standards Institute (CLSI) guidelines. Results: Among the samples which showed the presence of bacteria, around 29.04% samples were of sputum followed by urine and blood which contributed to 21.95% and 12.51%, respectively. Escherichia coli (39.55%) was found to be the most dominant pathogen, followed by Pseudomonas aeruginosa (19.12%), Klebsiella pneumoniae (12.39%), Proteus mirabilis (8.50%), Klebsiella oxytoca (8.26%), Acinetobacter baumannii (5.31%), Morganella morganii (3.77%), Serratia marcescens (2.24%). The susceptibility of Elores was comparable with meropenem in some of the organisms, but Elores displayed higher susceptibility in E. coli, A. baumannii, K. pneumoniae, P. mirabilis, K. oxytoca, M. morganii and S. mercescens which might be due to presence of metallo-beta lactamases in these isolates. Conclusion: Overall, the results of this study strongly advocate the equivalance of Elores with meropenem and can be of very effective alternative to treat against the deadly multi drug resistant Gram-negative bacteria. Keywords: Elores, Gram-negative bacteria, Nosocomial infections, Antimicrobial Resistance, Susceptibility.
Pulmonary venous admixture during one‐lung anaesthesia

Previous studies during one-lung anaesthesia have demonstrated low arterial oxygen tension’,’ and the pulmonary venous admixture (shunt) was estimated from assumed values for the arterial-venous oxygen content difference,334 which however, were larger than those actually found under halothane anae~thesia . ~ This resulted in an underestimate of the shunt. The present study was undertaken to measure the shunt under clinical conditions and to determine what effect varying the inhaled oxygen tension and respiration rate had on the shunt, arterial oxygen tcnsion and content.
CYP2F1 genetic polymorphism: Identification of interethnic variations

Since human cytochrome P450 2F1 (CYP2F1) is predominantly expressed in lung tissue and is involved in the metabolism of various pneumotoxicants with potential carcinogenic effects, variations in the nucleotidic sequence of its gene may contribute to interindividual and interethnic differences in the susceptibility to lung tumorigenesis. The aim of the current study was to compare the frequency of a previously reported frameshift mutation, namely c. 14_15insC, responsible for the synthesis of a severely truncated protein, between several populations of different ethnic origins. The frequencies of this polymorphism were 26.1, 51.6, 42.7 and 22.9% in French, Gabonese, Senegalese, and Tunisian population samples, respectively, thereby representing a substantial inter ethnic variation in the CYP2F1 gene. These findings provide data for further studies that investigate the potential association of CYP2F1 haplotypes with an incidence of lung cancer genesis in respect of ethnicity.
Origin of suppressed demixing in casein/xanthan mixtures

We explore the properties of casein/xanthan mixtures for xanthan concentrations beyond those inducing phase separation. Previous work has successfully described the onset of demixing by depletion theory in the protein limit, where the xanthan polysaccharides, the polymers, are larger than the caseins from skim milk powder, the colloids (S. Bhat et al., J. Phys.: Condens. Matter, 2006, L339). We now extend these studies to xanthan concentrations in a range of c/c* = 13–88, aiming to arrest the phase separation via a (transiently) arrested casein-rich phase. Surprisingly, we find that the casein-rich phase remains fluidic deep into the two-phase region, with an equilibrium composition that significantly differs from predictions for mixtures of hard spheres plus flexible polymer chains in a good solvent. Furthermore, we show that macroscopic phase separation is arrested for c/c* > 60. Our investigations reveal that the rheological properties of the mixtures are fully determined by the xanthan-rich phase with characteristic long relaxation times that depend remarkably strongly on the xanthan concentration.
The Effect of Different Rest Intervals Between Sets on Volume Components and Strength Gains

The purpose of this study was to compare squat strength gains and volume components when resting 2 minutes vs. 4 minutes between sets over multiple mesocycles. After the first squat 1 repetition maximum, 15 trained men were matched and randomly assigned to either a 2-minute (n = 7) or a 4-minute (n = 8) rest interval group. Each group performed the same training program, with the only difference being the length of the rest interval between sets. Subjects performed two squat workouts per week; one was labeled as Heavy and the other was labeled as Light. The squat workouts varied in the intensity, number of sets, and repetitions performed per set in a nonlinear periodized manner throughout each mesocycle. Differences in strength gains and volume components (the load utilized per set, the repetitions performed per set, the intensity per set, and the volume performed per workout) were compared between groups. Both groups demonstrated large strength gains; however, these differences were not significant between groups (P = 0.47). During all mesocycles, the 4-minute group demonstrated significantly higher total volumes for the Heavy workouts (P < 0.05). The findings of the present study indicate that large squat strength gains can be achieved with a minimum of 2 minutes' rest between sets, and little additional gains are derived from resting 4 minutes between sets. Therefore, athletes attempting to achieve specific volume goals may need longer rest intervals initially but may later adapt so that shorter rest intervals can be utilized without excessive fatigue, leaving additional time to focus on other conditioning priorities.
Innovative moments and poor outcome in narrative therapy

Abstract Aims: To analyse a poor outcome case of narrative therapy with a woman victim of intimate violence. Method: The Innovative Moments Coding System: version 1 was applied to all sessions to track the innovative moments (i-moments) in the therapeutic process. I–moments are the narrative details that occur in psychotherapeutic conversations that are outside the influence of the problematic narrative. This research aims to describe the processes involved in the stability of meanings in psychotherapy through a dialogical approach to meaning making. Findings: Contrarily to what usually occurs in good outcome cases, re-conceptualization i-moments are absent. Moreover, two specific types of i-moments emerged with higher duration: reflection and protest. Qualitative analysis showed that the potential meanings of these i-moments were surpassed by a return to the problematic narrative. Conclusion: The therapeutic stability seems to be maintained by a systematic return to the problematic narrative after the em.
Students' Use of Social Media During the Travel Process

Purpose – The purpose of the study is to explore how students as an important travel segment are involved in social media during the travel process and explore the underlying dimensions of social media use by students during the travel process. Design/methodology/approach – The quantitative research focuses on the students’ use of social media in the three phrases of the travel process – before travel, during travel and after travel separately. Survey instrument was a structured questionnaire. Data were collected through online survey using Google Drive. Descriptive statistics and principal component analysis are performed in the study to comprehend the students’ use of social media during the travel process. Findings – The findings of the study give an insight into the use of social media among students. They use mostly Facebook during the travel process, but traditional sources of information remain still relevant. Study findings reveal that social media are mostly used before travel begins and less during and after travel. There are identified two dimensions – “search for opinions” and “information and comparison” – that drive students to use social media before travel and two dimensions – “sociability” and “information” – that drive students to use social media during travel. Just one dimension labelled “sociability” emerged in relation to the use of social media after travel. Originality of the paper – The paper enhances the slim body of research on the use of social media among students during the travel process and raises awareness on social media use during the three phases of the travel process.
Allosteric pathways in imidazole glycerol phosphate synthase

Protein allosteric pathways are investigated in the imidazole glycerol phosphate synthase heterodimer in an effort to elucidate how the effector (PRFAR, N′-[(5′-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamide ribonucleotide) activates glutaminase catalysis at a distance of 25 Å from the glutamine-binding site. We apply solution NMR techniques and community analysis of dynamical networks, based on mutual information of correlated protein motions in the active and inactive enzymes. We find evidence that the allosteric pathways in the PRFAR bound enzyme involve conserved residues that correlate motion of the PRFAR binding loop to motion at the protein-protein interface, and ultimately at the glutaminase active site. The imidazole glycerol phosphate synthase bienzyme is an important branch point for the histidine and nucleotide biosynthetic pathways and represents a potential therapeutic target against microbes. The proposed allosteric mechanism and the underlying allosteric pathways provide fundamental insights for the design of new allosteric drugs and/or alternative herbicides.
CREANDO VÍNCULOS ENTRE UNIVERSIDAD Y COMUNIDAD: EL PROYECTO SHERE ROM, UNA EXPERIENCIA DE APRENDIZAJE SERVICIO EN LA FACULTAD DE PSICOLOGÍA DE LA UNIVERSITAT AUTÒNOMA DE BARCELONA

In this article we describe the project Shere Rom, a network of links between the Autonomous University of Barcelona, gypsie communities and public schools in the metropolitan area of Barcelona. The analysis of the experience highlights two key elements of service learning: a) the project promotes the social return of the university to society, responding to real needs through educational intervention that is developed under the frame of research projects; b) promotes, in college students, the acquisition of knowledge and the development of its own training curriculum skills through participation in a real project and community involvement. After 16 years, with a participation each year between 110 and 140 UAB students and between 250 and 300 children from different ethnic minorities, we can describe the potential that the project offers to each of its participants.
Greater sciatic notch in sex determination.

Various measurements of the greater sciatic notch, e.g. width, depth and length of the posterior segment (of width) were measured, and indices I and II calculated, in 200 adult hip bones (120 males and 80 females). Total and posterior angles were measured after construction of a triangle from the above measurements in each case. Demarking points for sexing of hip bones were calculated for the above seven parameters on the lines of Jit & Singh (1966). Width and depth of the greater sciatic notch were found to be useless criteria for sexing purposes while the posterior angle was found to be the best parameter, which identified 75% of left and 88% of right male hip bones and 92% of left and 100% of right female bones. Length of the posterior segment and Index II also assigned sex to a high percentage of hip bones, especially to the female ones (95-97%), which suggests that the widening of the greater sciatic notch found in females has occurred primarily in its posterior part. The demarking points identify sex with 100% accuracy.