Miracle-dz/UniFAR-FTUs huggingface dataset:
Internet privacy concerns and their antecedents - measurement validity and a regression model

This research focuses on the development and validation of an instrument to measure the privacy concerns of individuals who use the Internet and two antecedents, perceived vulnerability and perceived ability to control information. The results of exploratory factor analysis support the validity of the measures developed. In addition, the regression analysis results of a model including the three constructs provide strong support for the relationship between perceived vulnerability and privacy concerns, but only moderate support for the relationship between perceived ability to control information and privacy concerns. The latter unexpected results suggest that the relationship among the hypothesized antecedents and privacy concerns may be one that is more complex than is captured in the hypothesized model, in light of the strong theoretical justification for the role of information control in the extant literature on information privacy.
Venlafaxine: A Structurally Unique and Novel Antidepressant

Objective: To introduce the new antidepressant venlafaxine. Basic pharmacokinetic data and clinical trials are reviewed, as well as adverse reactions, drug interactions, dosing guidelines, and therapeutic considerations. The article also discusses several pharmacotherapy issues and how venlafaxine compares with other available antidepressants. Data Sources: A MEDLINE search was used to identify pertinent literature, including reviews. Study Selection: As this is a relatively new agent, all available clinical trials were reviewed. Data Extraction: All clinical trials that were available prior to submission for publication were reviewed. Preliminary trials and unpublished reports were not reviewed. Data Synthesis: Venlafaxine hydrochloride is a structurally novel agent that has recently been approved in the US for the treatment of depression. This unique antidepressant blocks neuronal reuptake of norepinephrine, serotonin, and, to a lesser extent, dopamine. Venlafaxine and its major active metabolite, O—desmethylvenlafaxine, exhibit linear kinetics with an elimination half-life of 5 and 11 hours, respectively. Venlafaxine has been evaluated in 7 clinical trials for the treatment of depression. These have consisted of 2 open trials, 3 double-blind, placebo-controlled trials, and 2 double-blind trials where venlafaxine was compared with trazodone and imipramine. All 7 trials have established efficacy for venlafaxine using standard psychiatric rating scales to measure change of depressive symptoms. The usual daily dosage ranges from 75 to 225 mg/d in 2 to 3 divided doses, with a maximum daily dosage of 375 mg/d. The drug's adverse effect profile differs somewhat from other more specific serotonin reuptake inhibitors in that it appears to cause dry mouth, somnolence, and elevated blood pressure as well as nausea, headache, and dizziness. Conclusions: Although venlafaxine has recently become available for use as an antidepressant in the US, few clinical trials have been conducted to help the practitioner evaluate its place in the treatment of depression. There are no comparative trials of venlafaxine with the serotonin specific reuptake inhibitor antidepressants, which are rapidly becoming the newest comparative standard. The clinical place for venlafaxine in the treatment of depression has yet to be determined.
Influence of strain field on nanoscale electronic processes in silicon-based semiconductors

The effects of strain field are studied in Si wafers implanted with heavy iodine and bismuth ions and in multi-quantum well structures. The experimental method of thermally stimulated currents without applied bias is used, and the trapping centres parameters are determined by modelling the discharge curves. In both cases, the strain field produces temperature-dependent parameters of trapping levels. So, due to the high strain field in the neighbourhood of implanted ions, energy levels broaden and cross sections become temperature dependent. In multilayer structures, for the trapping centres corresponding to strain-induced defects both concentrations and capture cross sections are temperature dependent.
Hippocampal neurons in the monkey with activity related to the place in which a stimulus is shown

In order to analyze the functions of the hippocampus in the primate, and to advance the understanding of amnesia, the activity of 994 single hippocampal neurons in the monkey was analyzed during the performance of a task known to be affected by hippocampal damage in which both an object, and its position in space, must be remembered. The serial multiple object-place memory task required a memory for the position on a video monitor in which a given object had appeared previously. It was found that 9.3% of neurons recorded in the hippocampus and hippocampal gyrus had spatial fields in this and related tasks, in that they responded whenever there was a stimulus in some but not in other positions on the screen. We found that 2.4% of the neurons responded to a combination of spatial information and information about the object seen, in that they responded more the first time a particular object was seen in any position. Six of these neurons were found that showed this combination even more clearly, in that, for example, they responded only to some positions and only if it was the first time that a particular stimulus had appeared there. It is concluded that there are neurons in the primate hippocampus which (1) respond to position in space and (2) in some cases combine information about stimuli and their position in space, responding to a stimulus only the first time it is seen in a position in space, for example. Thus, not only is spatial information processed by the primate hippocampus, but it can be combined with information about which stimuli have been seen before. The ability of the hippocampus to form such conjunctions may be an important property for its role in memory.
Stability and change in adolescents' personality: a longitudinal study

The present study examined three types of personality change and continuity (mean‐level, individual‐level, and rank‐order stability) over the 2‐year period in a nationally representative longitudinal sample of Estonian adolescents (N = 876) aged 12–18. According to the Reliable Change Index, 82.1% of adolescents maintained the same level on any given personality trait measured by the NEO Five‐Factorial Inventory (NEO‐FFI) indicating that the individual‐level continuity of adolescents did not differ compared to young adults. A reliable increase was found in Openness. Across the five dimensions, the average test–retest correlations were 0.51, 0.56 and 0.67, and the computed biennial stability values were 0.80, 0.83 and 0.89 for age groups 12 → 14, 14 → 16 and 16 → 18 years, respectively. Neither intelligence nor school performance moderated the differential continuity. Copyright © 2006 John Wiley & Sons, Ltd.
Boötes-HiZELS: an optical to near-infrared survey of emission-line galaxies at z = 0.4-4.7

We present a sample of ∼1000 emission-line galaxies at z = 0.4–4.7 from the ∼0.7deg^2 High-z Emission-Line Survey in the Bootes field identified with a suite of six narrow-band filters at ≈0.4–2.1 μm. These galaxies have been selected on their Ly α (73), [O II] (285), H β/[O III] (387) or H α (362) emission line, and have been classified with optical to near-infrared colours. A subsample of 98 sources have reliable redshifts from multiple narrow-band (e.g. [O II]–H α) detections and/or spectroscopy. In this survey paper, we present the observations, selection and catalogues of emitters. We measure number densities of Ly α, [O II], H β/[O III] and H α and confirm strong luminosity evolution in star-forming galaxies from z ∼ 0.4 to ∼5, in agreement with previous results. To demonstrate the usefulness of dual-line emitters, we use the sample of dual [O II]–H α emitters to measure the observed [O II]/H α ratio at z = 1.47. The observed [O II]/H α ratio increases significantly from 0.40 ± 0.01 at z = 0.1 to 0.52 ± 0.05 at z = 1.47, which we attribute to either decreasing dust attenuation with redshift, or due to a bias in the (typically) fibre measurements in the local Universe that only measure the central kpc regions. At the bright end, we find that both the H α and Ly α number densities at z ≈ 2.2 deviate significantly from a Schechter form, following a power law. We show that this is driven entirely by an increasing X-ray/active galactic nucleus fraction with line luminosity, which reaches ≈100 per cent at line luminosities L ≳ 3 × 10^(44) erg s^(−1).
Endovascular treatment of 306 anterior communicating artery aneurysms: overall, perioperative results.

OBJECT A series of 306 consecutive patients with an anterior communicating artery (ACoA) aneurysm is presented. The goal in this study was to report the results of endovascular treatment of ACoA aneurysms in these patients. METHODS The aneurysms were managed with an endovascular approach in which detachable coils were used. A brief anatomical description of the ACoA and its branches as well as a review of the surgical and endovascular literature is presented. The "ACoA Syndrome" (that is, amnesia and personality changes), which may occur after subarachnoid hemorrhage, is briefly reviewed and described. Recent technical developments that can lead to improved results are also discussed. RESULTS Of the 306 aneurysms, 268 (87.5%) were small, 30 (10%) were large, and 8 (2.6%) were giant. One hundred ninety-three aneurysms (63%) had a small neck, whereas 113 (37%) had a wide neck. Sixty-five lesions (21%) were incidental, 5 (2%) presented with symptoms of mass effect, and 236 (77%) presented with a subarachnoid hemorrhage. A complete aneurysm occlusion was attained in 139 cases (45.5%), a neck remnant was detected in 145 (47.5%), and in 22 cases (7%) a residual filling of the aneurysm was observed. Regarding the clinical neurological outcome, 280 patients (91.5%) remained neurologically intact, improved, or unchanged from their initial clinical status. Two large, wide-necked, subtotally occluded aneurysms ruptured 3-7 months after the procedure, with subsequent death of the patients. The procedure-related morbidity and mortality rates were 3.5% (11 cases) and 1% (3 cases), respectively. CONCLUSIONS The inherently lower risk of injuring or occluding the delicate branches and perforating vessels arising from the ACoA makes the endovascular approach attractive, interesting, and elegant.
Morphological and molecular alterations at the junctional complex in irradiated human colon adenocarcinoma cells, Caco-2

Purpose: Ionizing radiation is one of the main modalities used in the treatment of colorectal cancer. Despite a number of epigenetic or non-targeted effects of radiation exposure that have been described, the effect of radiation on cell-cell adhesion in the epithelium has been less studied. We report morphological and molecular alterations induced by ionizing radiation at the junctional complex level of human colon cancer Caco-2 cells. Materials and methods: Cells were irradiated with doses of 2, 5 or 10 Gy and the effects on the junctional complex were monitored for different times after irradiation. Alterations of tight and adherens junction components were observed by measuring the transepithelial electrical resistance, by immunofluorescence and immunoblotting and electron microscopy analyses. Results: Ionizing radiation caused alterations in the junctional complex, as evidenced by: (a) a decrease in the transepithelial electrical resistance, (b) alterations in the pattern of the distribution of junctional proteins as observed for E-cadherin, occludin, and zonula occludens 1 (ZO-1), but with minor changes in claudin-1 localization, and (c) wide spaces between opposed cells. These effects were dose and time-dependent since minor doses of irradiation caused a reversible effect on E-cadherin distribution and transepithelial electrical resistance. Conclusions: The results obtained show that ionizing radiation caused redistribution of the main junctional proteins E-cadherin, occludin and ZO-1 with minor changes for claudin-1, leading to disassembly of the junctional complex and loss of its functionality in Caco-2 cells. The molecular mechanisms responsible for these events need further elucidation.
A unique spectrum of p53 mutations in B‐cell chronic lymphocytic leukemia distinct from that of other lymphoid malignancies

The spectrum and pattern of p53 mutations detected in 42 cases of B‐cell chronic lymphocytic leukemia (B‐CLL) were analyzed, and several interesting features were noted. Codon 209 in the p53 gene may be a new hot‐spot for p53 mutation in B‐CLL disease. Four of the 42 (10%) reported B‐CLL p53 mutations occurred at codon 209 versus none in 214 cases of other lymphoid malignancies screened for p53 mutations (P = 0.0006). Transversion mutations predominated at codon 273 rather than the transition mutations that are known to occur at this CpG site. Four of six (67%) B‐CLL cases had transversions at codon 273 compared with two of 17 (12%) of all other lymphoid tumors examined (P = 0.02). In addition, over 65% of the p53 mutations detected in B‐CLL showed a strand bias for p53 mutations on the untranscribed DNA strand. This feature of DNA strand bias is notable in cancers of the lung, esophagus, and head and neck, which may result from high exposure to carcinogens. This spectrum of p53 mutations in B‐CLL together with the high frequency of transversion mutations and DNA strand bias may implicate environmental carcinogens associated with p53 gene damage in some B‐CLL patients. © 1995 Wiley‐ Liss, Inc.
Antigen-specific B-1a antibodies induced by Francisella tularensis LPS provide long-term protection against F. tularensis LVS challenge

Francisella tularensis (Ft), a Gram-negative intracellular bacterium, is the etiologic agent of tularemia. Infection of mice with <10 Ft Live Vaccine Strain (Ft LVS) organisms i.p. causes a lethal infection that resembles human tularemia. Here, we show that immunization with as little as 0.1 ng Ft LVS lipopolysaccharide (Ft-LPS), but not Ft lipid A, generates a rapid antibody response that protects wild-type (WT) mice against lethal Ft LVS challenge. Protection is not induced in Ft-LPS-immunized B cell-deficient mice (μMT or JhD), male xid mice, or Ig transgenic mice that produce a single IgH (not reactive with Ft-LPS). Focusing on the cellular mechanisms that underlie this protective response, we show that Ft-LPS specifically stimulates proliferation of B-1a lymphocytes that bind fluorochrome-labeled Ft-LPS and the differentiation of these cells to plasma cells that secrete antibodies specific for Ft-LPS. This exclusively B-1a antibody response is equivalent in WT, T-deficient (TCRαβ−/−, TCRγδ−/−), and Toll-like receptor 4 (TLR4)-deficient (TLR4−/−) mice and thus is not dependent on T cells or typical inflammatory processes. Serum antibody levels peak ≈5 days after Ft-LPS immunization and persist at low levels for months. Thus, immunization with Ft-LPS activates a rare population of antigen-specific B-1a cells to produce a persistent T-independent antibody response that provides long-term protection against lethal Ft LVS infection. These data support the possibility of creating effective, minimally invasive vaccines that can provide effective protection against pathogen invasion.
Spatial differentiation in the eastern Pacific yellowfin tuna revealed by microsatellite variation

Five eastern Pacific yellowfin tuna samples (four northern: 10–25°N, 95–130°W, and one southern: 16–18°S, 95–97°W), collected from fishing vessels between 1994 and 2002 were analyzed for variation at seven microsatellite loci to evaluate their spatial genetic homogeneity. Single-locus homogeneity exact tests revealed significant genetic differentiation caused by three of seven loci. Pairwise sample comparisons of multilocus allele-frequency homogeneity tests and subpopulation division (FST), revealed significant differentiation in comparisons between north equatorial samples and the south equatorial sample. AMOVA analysis among collections grouped as northern and southern populations separated by the equator in the eastern Pacific confirmed the differentiation observed. These results may be considered as preliminary evidence of the presence of discrete populations in the eastern Pacific yellowfin tuna. The possibility that the spatial differentiation observed corresponds to temporal variation or non-random sampling cannot be discarded. The genetic differences encountered need to be corroborated by increasing sample sizes, including temporal replicates, and by the use of an alternative marker.
Characterization of CAX4, an Arabidopsis H+/Cation Antiporter1

Ion compartmentalization is essential for plant growth and development. The Arabidopsis open reading frames for CAX1, CAX2, and CAX3 (cation exchangers 1, 2, and 3) were previously identified as transporters that may modulate ion fluxes across the vacuolar membrane. To understand the diversity and role of H+/cation transporters in controlling plant ion levels, another homolog of theCAX genes, CAX4, was cloned from an Arabidopsis cDNA library. CAX4 is 53% identical to CAX1 at the amino acid level, 42% identical to CAX2, and 54% identical to CAX3.CAX4 transcripts appeared to be expressed at low levels in all tissues and levels of CAX4 RNA increased after Mn2+, Na+, and Ni2+ treatment. An N-terminal CAX4-hemagglutinin fusion appeared to localize to both yeast and plant vacuolar membranes. When expressed in yeast, CAX4, like CAX3, failed to suppress the Ca2+ sensitivity of yeast strains deficient in vacuolar Ca2+ transport. Several modifications to CAX4 allowed the protein to transport Ca2+. Addition of amino acids to the N terminus of CAX4 and CAX3 caused both transporters to suppress the sensitivity of yeast strains deficient in vacuolar Ca2+ transport. These findings suggest that CAX transporters may modulate their ion transport properties through alterations at the N terminus.
Motion tolerance in wearable sensors - The challenge of motion artifact

Motion artifact is a major limitation in most practical implementations of wearable health monitoring devices. Especially in applications requiring continuous monitoring and high specificity, motion artifact can render a solution infeasible in real world use cases. We believe that the single most important technical challenge that will decide the success of wearable biomedical sensor systems is signal integrity. Principle possibilities to reduce artifact are explained, and some historical and modern examples are given, showing the relevance of this subject. However, still no proper models for artifact exist, nor is there a generalized approach to deal with this problem. This paper intends to call to attention the need for a common understanding in the community for a method of addressing this area objectively, and proposes next steps toward this goal.
A Q-Band Low-Profile Dual Circularly Polarized Array Antenna Incorporating Linearly Polarized Substrate Integrated Waveguide-Fed Patch Subarrays

An integrated low-profile dual circularly polarized (dual CP) array antenna operating in the Q-band is proposed in this paper, which is realized by sequentially rotating subarrays comprised linearly polarized (LP) substrate integrated waveguide (SIW)-fed patches. The design methodology and working mechanism of the LP SIW-fed patches is presented first, which is implemented with a two-layer printed circuit board structure where the SIW feeding network is located in the bottom substrate and the patches are on the top substrate. Four subarrays are then arranged according to the requirements of a sequential rotation array for producing CP directive beams. A two-layer SIW feeding network for providing the required amplitude and phase distributions for the four subarrays is designed, which includes two input ports for exciting CP radiation with opposite handedness, respectively. Prototypes of the LP subarray and the integrated dual CP array antenna were fabricated and measured. Good agreement between the simulation and measured results validates the designs. The proposed low-cost and lightweight dual CP antenna owns the advantages of wide useful bandwidth (8.9%), high isolation of more than 19 dB, low profile of less than $0.1\lambda _{0}$ , and good orthogonal polarization discrimination higher than 25 dB.
SHIMMER™: An extensible platform for physiological signal capture

Wireless sensor networks have become increasingly common in everyday applications due to decreasing technology costs and improved product performance, robustness and extensibility. Wearable physiological monitoring systems have been utilized in a variety of studies, particularly those investigating ECG or EMG during human movement or sleep monitoring. These systems require extensive validation to ensure accurate and repeatable functionality. Here we validate the physiological signals (EMG, ECG and GSR) of the SHIMMER (Sensing Health with Intelligence, Modularity, Mobility and Experimental Reusability) against known commercial systems. Signals recorded by the SHIMMER EMG, ECG and GSR daughter-boards were found to compare well to those obtained by commercial systems.
Causes of death in hospitalized adults with a premortem diagnosis of tuberculosis: an autopsy study

Objective:To ascertain the immediate and underlying causes of death in adults who died in hospital with a premortem diagnosis of tuberculosis. Design:Causes of death were assessed independently by internists and pathologists in 50 adults admitted to two Soweto hospitals who died 24 h or more after admission. Detailed record reviews and complete autopsies including HIV tests when not performed premortem were performed. In addition, a variety of postmortem microbiological tests were performed. Results:Forty-seven patients had HIV infection; all were antiretroviral naive. Their median age was 34.5 years, median CD4 cell count was 48 cells/μl and median length of hospitalization before death was 6 days. Autopsy confirmed the premortem diagnosis of tuberculosis in 37 HIV-infected patients (79%), whereas 10 (21%) did not demonstrate tuberculosis. Bronchopneumonia and cytomegalovirus pneumonitis were the leading pathologies in these 10 patients. In 47 HIV-infected cadavers immediate or contributory causes of death were: extensive pulmonary tuberculosis, 32 (68%); disseminated tuberculosis, 28 (60%); bacterial pneumonia, 13 (26%); cytomegalovirus pneumonitis in seven (15%); cytomegalovirus DNA was found in 31 (66%) and Pneumocystis pneumonia was found in five cadavers (11%). The lung, followed by lymph nodes, liver and kidney, were the commonest sites of tuberculosis. Mycobacterium tuberculosis was cultured from 19 spleens, one of which was multidrug resistant, and Salmonella spp. was cultured from 11 splenic specimens. Conclusion:We demonstrated disseminated, extensive tuberculosis associated with advanced HIV disease. Severe bacterial infections, including salmonellosis, were the leading co-morbidity, suggesting that hospitalized HIV-infected adults in whom tuberculosis is suspected may benefit from broad-spectrum antibiotic therapy.