Miracle-dz/UniFAR-FTUs huggingface dataset:
Metabolic bioactivation and drug-related adverse effects: current status and future directions from a pharmaceutical research perspective

Retrospective studies indicate that many drugs that cause clinical adverse reactions, such as hepatotoxicity, undergo metabolic bioactivation, resulting in the formation of electrophilic intermediates capable of covalently modifying biological macromolecules. A logical extension of these findings is a working hypothesis that compounds with reduced levels of bioactivation should be inherently safer drug molecules and thus have a greater likelihood of success in drug development. Whereas some research-based pharmaceutical companies have adopted a strategy of addressing metabolic bioactivation early in drug discovery, much skepticism remains on whether such an approach would enable the industry to reach the desired objectives. The debate is centered on the question of whether there is a quantitative correlation between bioactivation and the severity of drug-treatment–related toxicity, and whether covalent protein modification represents only one of several possible mechanisms underlying observed tissue injury. This communication is intended to briefly review the current understanding of drug-induced hepatotoxicity and to discuss the controversy and future directions with respect to the effort of minimizing the probability of clinical adverse reactions.
Pedagogy beyond compliance: teachers providing opportunities for students to self-regulate their learning in the primary-secondary transition years of schooling

This study explored how teachers provided opportunities for young adolescent students to be empowered as learners. Despite the crucial role that self-regulated learning plays in enhancing students’ achievement at school and beyond, few studies have created a practice-based pedagogy aimed at enabling students to rationalise their goals, to accept responsibility for their learning and to develop their capabilities as resourceful learners in social learning environments. The research was conducted as dual case studies within a primary school and a secondary school as transitionally connected settings in Queensland, Australia. The middle years of schooling, Years 5 to 9, have been identified as being a critical stage of development in young adolescents’ lives for effective lifelong learning. How schools and teachers can contribute to fostering these learning qualities was highlighted as a topic relevant to current Australian and international educational policy and debate. Rich qualitative data were collected through semi-structured interviews and classroom observations from eight teacher participants in the middle years of schooling. Thematic analysis methods were used in inductive intra-case and cross-case processes of generating codes, categories and themes. The findings were reported as interpretations that were intertwined with snapshots of data that represented the voices of the teacher participants. The data foregrounded teachers’ practices to identify that in striving to foster students’ effective learning they implemented pedagogical approaches aimed beyond the management of students’ behaviour for compliance and they sought to empower students as resourceful learners. As an original contribution to knowledge, the findings were synthesised to construct a practice-based pedagogical model for self-regulated learning. The study found that the teachers endeavoured to provide opportunities for the students to regulate their own learning through pedagogical approaches that connect the learning, facilitate the learning, diversify the learning, socialise the learning and reflect on teaching. Extending this model, the transition pedagogy framework for self-regulated learning presents key elements that attend to the distinctive needs of young adolescent students in the primary–secondary transition years of schooling. This study’s findings offer a proactive pedagogical approach to behaviour management within classroom environments that focuses on potentiating students’ self-regulation of their learning.
Ethnic disparities among food sources of energy and nutrients of public health concern and nutrients to limit in adults in the United States: NHANES 2003–2006

Background Identification of current food sources of energy and nutrients among US non-Hispanic whites (NHW), non-Hispanic blacks (NHB), and Mexican American (MA) adults is needed to help with public health efforts in implementing culturally sensitive and feasible dietary recommendations. Objective The objective of this study was to determine the food sources of energy and nutrients to limit [saturated fatty acids (SFA), added sugars, and sodium] and nutrients of public health concern (dietary fiber, vitamin D, calcium, and potassium) by NHW, NHB, and MA adults. Design This was a cross-sectional analysis of a nationally representative sample of NWH (n=4,811), NHB (2,062), and MA (n=1,950) adults 19+ years. The 2003–2006 NHANES 24-h recall (Day 1) dietary intake data were analyzed. An updated USDA Dietary Source Nutrient Database was developed using current food composition databases. Food grouping included ingredients from disaggregated mixtures. Mean energy and nutrient intakes from food sources were sample-weighted. Percentages of total dietary intake contributed from food sources were ranked. Results Multiple differences in intake among ethnic groups were seen for energy and all nutrients examined. For example, energy intake was higher in MA as compared to NHB; SFA, added sugars, and sodium intakes were higher in NHW than NHB; dietary fiber was highest in MA and lowest in NHB; vitamin D was highest in NHW; calcium was lowest in NHB; and potassium was higher in NHW as compared to NHB. Food sources of these nutrients also varied. Conclusion Identification of intake of nutrients to limit and of public health concern can help health professionals implement appropriate dietary recommendations and plan interventions that are ethnically appropriate.
Hypothalamic expression of anorexigenic and orexigenic hormone receptors in obese females Neotomodon alstoni: Effect of fasting

Abstract Obesity is a world problem that requires a better understanding of its physiological and genetic basis, as well as the mechanisms by which the hypothalamus controls feeding behavior. The volcano mouse Neotomodon alstoni develops obesity in captivity when fed with regular chow diet, providing a novel model for the study of obesity. Females develop obesity more often than males; therefore, in this study, we analysed in females, in proestrous lean and obese, the differences in hypothalamus expression of receptors for leptin, ghrelin (growth hormone secretagogue receptor GHS-R), and VPAC, and correlates for plasma levels of total ghrelin. The main comparisons are between mice fed ad libitum and mice after 24 hours of fasting. Mice above 65 g body weight were considered obese, based on behavioral and physiological parameters such as food intake, plasma free fatty acids, and glucose tolerance. Hypothalamic tissue from obese and lean mice was analysed by western blot. Our results indicate that after ad libitum food access, obese mice show no significant differences in hypothalamic leptin receptors, but a significant increase of 60% in the GHS-R, and a nearly 62% decrease in VPAC2 was noted. After a 24-hour fast, plasma ghrelin increased nearly two fold in both lean and obese mice; increases of hypothalamic leptin receptors and GHS-R were also noted, while VPAC2 did not change significantly; levels of plasma free fatty acids were 50% less after fasting in obese than in lean animals. Our results indicate that in obese N. alstoni mice, the levels of orexigenic receptors in the hypothalamus correlate with overfeeding, and the fact that lean and obese females respond in different ways to a metabolic demand such as a 24-hour fast.
Are Fair Weather Fans Affected by Weather? Rainfall, Habit Formation, and Live Game Attendance

We analyze habit formation in sports attendance utilizing rainfall as an unexpected, transitory shock to attendance costs. Using attendance data from Major League Baseball (MLB) and National Oceanic and Atmospheric Administration weather data, we analyze the impact of variation in game day weather conditions on current and future MLB attendance. The empirical strategy permits identification of both the formation and persistence of habit from exogenous weather shocks. Past adverse weather shocks increase future attendance by about 200 fans per game. This contributes to the literature developing empirical evidence of habit formation in the field and provides policy implications for optimal ticket-pricing strategies.
Cytotoxicity of Various Endodontic Materials on Stem Cells of Human Apical Papilla

Introduction: This in vitro study assessed and compared the cytotoxicity of mineral trioxide aggregate (MTA), calcium-enriched mixture (CEM) cement, Biodentine (BD) and octacalcium phosphate (OCP) on stem cells of the human apical papilla (SCAP). Methods and Materials: SCAPs were isolated from two semi-impacted third molars. The cells were cultured in wells of an insert 24-well plate and were then incubated. The plates were then removed from the incubator and randomly divided into four experimental groups that were exposed to 1-mm discs of set MTA, CEM, BD or OCP, and one untreated control group. After 24, 48 and 168 h, the plates were removed from the incubator and 3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyl tetrazolium bromide (MTT) solution was added to each well. Data were analyzed at different time points using the repeated measures ANOVA followed by Bonferroni test and the level of significance was set at 0.05. Results: Cytotoxicity of the four materials was not significantly different from that of the control group at 24, 48 and 168 h (P>0.05). Two-by-two comparison revealed that cytotoxicity of MTA and CEM cement was significantly different from each other at 168 h (P<0.05) although the cytotoxicity of CEM was less than MTA. Cytotoxicity of OCP and MTA was also significantly different from each other at 48 h and OCP had more favorable biocompatibility than MTA (P<0.05). Conclusion: CEM, OCP, BD and MTA showed acceptable biocompatibility when exposed to SCAP. Over time, CEM showed the least cytotoxicity among the materials under study.
The SEU Cross Section Estimation in SRAM Induced by Protons of Space Environment

The main goal of this paper is to propose an approach to calculate proton induced SEU cross sections. The starting point is the RPP sensitive volume model and some reasonable assumptions. An approximate analytic calculational model is presented, by which the valid number of the heavy ions induced by the interaction of proton and Si nuclei will be obtained. Then, the saturated proton SEU cross section for the typical 6T SRAM can be calculated by using this number and the experimental data of heavy ions. The calculated proton SEU cross section is in good agreement with experiment results.
Patterns of Second‐to‐Fourth Digit Length Ratios (2D:4D) in Two Species of Frogs and Two Species of Lizards at La Selva, Costa Rica

It is now well documented that androgen and estrogen signaling during early development cause a sexual dimorphism in second‐to‐fourth digit length ratio (2D:4D). It is also well documented that males of mammalian species have a smaller 2D:4D than females. Although there are discrepancies among 2D:4D studies in birds, the consensus is that birds exhibit the opposite pattern with males having a larger 2D:4D than females. The literature currently lacks substantial information regarding the phylogenetic pattern of this trait in amphibians and reptiles. In this study, we examined 2D:4D in two species of frogs (Oophaga pumilio and Craugastor bransfordii) and two species of lizards (Anolis humilis and Anolis limifrons) to determine the existence and the pattern of the sexual dimorphism. Male O. pumilio and C. bransfordii displayed larger 2D:4D than females in at least one of their two forelimbs. Male A. humilis had larger 2D:4D than females in both hindlimbs, but smaller 2D:4D than females in both forelimbs. Male A. limifrons may also have smaller 2D:4D than females in the right forelimb. Finally, digit ratios were sometimes positively related to body length, suggesting allometric growth. Overall, our results support the existence of the 2D:4D sexual dimorphism in amphibians and lizards and add to the knowledge of 2D:4D trait patterning among tetrapods. Anat Rec, 2012. © 2012 Wiley Periodicals, Inc.
[Dietary intake of pregnant women and maternal weight gain after nutritional counseling].

PURPOSE to determine the dietary consumption of pregnant women, by assessing the intake of macronutrients and micronutrients, and to verify the maternal weight gain during pregnancy. METHODS a retrospective study conducted from June 2002 to June 2008 with pregnant women who received nutritional counseling during prenatal care at a university hospital, grouped according to anthropometric nutritional status classified by pregestational body mass index (BMI). The dietary intake was analyzed according to the information obtained in food frequency interviews, performed at the first evaluation of pregnant women in the service of nutrition to obtain data about eating habits, and the intake of macronutrients and micronutrients was calculated. The pregnant women received nutritional counseling, and the maternal weight gain was investigated. RESULTS a total of 187 pregnant women who received nutritional counseling were analyzed. Twenty-three (12.2%) were underweight, 84 (45.0%) normal weight, 37 (19.8%) overweight, and 43 (23.0%) obese. The underweight pregnant women had lower consumption of lipids when compared to the normal weight group (101.4 versus 137.3 g; p=0.043). The average iron intake was higher in normal weight pregnant women (14.6 mg/d) compared to the overweight (12.2 mg/d) or obese (10.9 mg/d; p<0.001) groups. The average intake of folate was higher in normal weight pregnant women compared to obese ones (336.5 µg/d versus 234.5 µg/d; p=0.002). Excessive maternal weight gain was significantly (p=0.009) more frequent in overweight (56.7%) and obese (39.5%) pregnant women compared to underweight (17.4%) and normal weight (31.0%) women. CONCLUSIONS The maternal weight gain above recommended levels was associated with overweight and obesity. The dietary intake of pregnant women differs according to maternal anthropometric nutritional status, with a lower daily intake of iron in overweight and obese women and a lower intake of folate in obese ones, a fact that reinforces the importance of prenatal vitamin supplementation.
Comparison of the effects of divalent cations on the noradrenaline‐evoked cation current in rabbit portal vein smooth muscle cells

1 The facilitatory effects of external Ca2+, Sr2+ and Ba2+ (Ca2+o, Sr2+o and Ba2+o) on the noradrenaline‐evoked non‐selective cation current (Icat) were compared in rabbit portal vein smooth muscle cells using patch pipette techniques. 2 All divalent cations tested potentiated the amplitude of Icat and the potency sequence was Ca2+o > Sr2+o > Ba2+o. Ca2+o and Sr2+o increased the amplitude of Icat by about eight times whereas Ba2+o produced only a threefold facilitation. 3 The current‐voltage relationship of Icat was not changed by Ca2+o, Sr2+o or Ba2+o. 4 From noise analysis the single channel conductance (γ) was approximately 10 pS in divalent cation‐free solution but was about 20 pS with Ca2+o, Sr2+o and Ba2+o. 5 From noise and voltage‐jump experiments it was apparent that at least three kinetically resolvable channel states are associated with Icat in divalent cation‐free solution. Ca2+o and Sr2+o produced marked changes in the characteristics of the power spectrum and relaxations of Icat in response to voltage steps, consistent with a shift in the equilibrium between the channel states, whereas Ba2+o produced minimal effects. 6 The data show that Ca2+o, Sr2+o and Ba2+o increase the amplitude of Icat, which results in part from an increase in the single channel conductance. In addition the results suggest that Ca2+o and Sr2+o alter the kinetic behaviour of the single channels whereas Ba2+o has little effect on the equilibrium between the channel states.
Much Ado about the Egyptian Pound: Exchange Rate Misalignment and the Path Towards Equilibrium

Abstract This paper estimates Egypt's equilibrium real exchange rate and exchange rate misalignment based on economic fundamentals over the period 2001Q3–2017Q3. Focusing on the more recent period, we find that the Egyptian pound was undervalued by about 22.3% in 2017Q1 due to overshooting its equilibrium value after floating the currency in 2016Q4. The currency undervaluation then declined to 18.5% in 2017Q3 driven by an increase in the real effective exchange rate due to a surge in domestic inflation. With regard to the determinants of the equilibrium real exchange rate, we find the productivity differential (vis-à-vis Egypt's trade partners) and trade openness to be the most significant factors. We also provide projections for the equilibrium real exchange rate and exchange rate misalignment until 2020Q4, which reveal that the exchange rate undervaluation will be dissipating fast due to high inflation. If the nominal exchange rate stabilizes at its level in 2017Q3 (17.73 pounds per US dollar), the currency will be overvalued by 13.1% in 2020Q4. Given the uncertainty surrounding the projections, a forecast combination approach is also presented. Finally, the paper highlights the implications of the empirical findings for the conduct of monetary policy in Egypt.
The Economic Reality of the Beauty Myth

We investigate income, marital status, and hourly pay differentials by body mass (kg/m 2 ) in a sample of 23- to 31-year-olds drawn from the 1988 NLSY. Obese women have lower family incomes than women whose weight-for-height is in the "recommended" range. Results for men are weaker and mixed. We find similar results when we compare same-sex siblings in order to control for family background (for example, social class) differences. Differences in economic status by body mass for women increase markedly when we use an earlier weight measure or restrict the sample to persons who were single and childless when the early weight was reported. There is some evidence of labor market discrimination against obese women. Differences in marriage probabilities and spouse's earnings, however, account for 50 to 95 percent of their lower economic status. There is little evidence that obese African American women suffer an economic penalty relative to other African American women.
Investigation of the initial dip in fMRI at 7 Tesla

In agreement with optical imaging studies, previous fMRI studies have reported an initial decrease (i.e. the initial dip) in the BOLD response, which is believed to arise from an increase in oxygen consumption and to be mostly microvascular. To date, experimental studies of the initial dip in humans have been performed at fields up to 4 T, with relatively low spatial resolution. Because the sensitivity to microvascular contribution is increased at high magnetic fields, the present study investigated the initial dip at 7 T. In addition, to reduce the partial volume effect, the study is conducted at a high spatial resolution. The initial dip was detected in all subjects studied and was found to reside mostly in the gray matter. The relative amplitude of the early response was found to be 0.6, higher than that at 4 T (0.3) and 1.5 T (0.11). In addition, based on the assumption that the initial dip is a result of increased oxygen utilization, the fractional change in oxygen utilization was estimated to be 40% of that of the fractional change in cerebral blood flow. These results are in agreement with the notion that the initial dip arises from an increase in oxygen consumption. Copyright © 2001 John Wiley & Sons, Ltd.
Incidence, kinetics, and risk factors of Epstein–Barr virus viremia in pediatric patients after allogeneic stem cell transplantation

Bordon V, Padalko E, Benoit Y, Dhooge C, Laureys G. Incidence, kinetics, and risk factors of Epstein–Barr virus viremia in pediatric patients after allogeneic stem cell transplantation. Pediatr Transplantation 2012: 16: 144–150. © 2012 John Wiley & Sons A/S.
[Everyday burden of mentally ill people's spouses -- client orientated approaches in relatives' support].

OBJECTIVE Regarding clinical practice groups for relatives of mentally ill people mostly are conceptualized depending on the type of disorder the patient is suffering from. However, results of research on burden of caregivers indicate aspects of burden which do not seem to be associated with the patients' disorder. METHOD As part of a study on the burden of caregiving to mentally ill family members in-depth interviews as well as diary writing over a 12 weeks period were carried out with 6 spouses of patients suffering from schizophrenia or depression. RESULTS Differences in the burden of caregiving do not seem to be related to the type of the patients' diagnosis. Aspects of partnership dominated the interviews and diary writing of the spouses. In all cases substantial parts of experienced burden are related to the spouses' efforts to share mastering of the illness with the patient. CONCLUSIONS The hypothesis of specific aspects regarding the type of the patients' disorder related to spouses caregiver burden can not be supported by the results of this study. However, our results seem to encourage aspects of relationship within the development of support programs for relatives of mentally ill people.
Self-Reported Parenting Style Is Associated With Children’s Inflammation and Immune Activation

Family environments and parenting have been associated with inflammation and immune activation in children and adolescents; however, it remains unclear which specific aspects of parenting drive this association. In this study, we cross-sectionally examined the association between 5 discrete parenting styles and inflammation and immune activation in late childhood. Data were drawn from 102 families (55 with female children, mean age 9.50 years, SD = 0.34) participating in the Imaging Brain Development in the Childhood to Adolescence Transition Study. Children provided saliva samples from which inflammation (C-reactive protein) and immune competence/activation (secretory immunoglobulin A) were measured. Parents completed the Alabama Parenting Questionnaire, which measures 5 aspects of parenting style—positive parental involvement, positive disciplinary techniques, consistency in disciplinary techniques, corporal punishment, and monitoring and supervision. Results showed that higher scores on the poor parental monitoring scale were associated with higher levels of both inflammation and immune activation in children. This study highlights parental monitoring and supervision as a specific aspect of parenting behavior that may be important for children’s physical and mental health.