Miracle-dz/UniFAR-FTUs huggingface dataset:
Reference intervals for Greyhounds and Lurchers using the Sysmex XT-2000iV hematology analyzer.

BACKGROUND The need for breed-specific reference intervals (RIs) for Greyhounds has been identified. As Lurchers are a sighthound cross-breed, specific RIs may also be needed for these dogs. Hematologic RIs for Greyhounds and Lurchers using the Sysmex XT-2000iV hematology analyzer have not been established. OBJECTIVES The aims of this study were to establish RIs for Greyhounds using the Sysmex XT-2000iV, to investigate whether RIs for Greyhound and nonsighthound dogs could be transferred to Lurchers, and to establish new RIs for Lurchers if transference was not possible. METHODS Data were retrieved retrospectively from a database of blood donor dogs. Greyhound RIs were established using nonparametric methods based on a reference population of 179 dogs. For the RI transference study, 38 Lurchers were selected, following guidelines proposed by the Clinical and Laboratory Standards Institute. When transference was not appropriate, new RIs were generated using the robust method. RESULTS Greyhound RIs for the Sysmex hematology analyzer reflected known differences in this breed with a tendency toward higher RBC mass and lower WBC and platelet counts. RIs for hemoglobin concentration, HCT, MCV, MCH, MCHC, and WBC, neutrophil, lymphocyte, monocyte, and platelet counts for Greyhounds were suitable for transference to Lurchers. For RBC and eosinophil counts, new RIs were established. CONCLUSION Our study suggests that Lurchers share many hematologic characteristics with Greyhounds, but had higher reference limits for RBC and eosinophil counts.
Information Asymmetry within Financial Markets and Corporate Financing Decisions

It is worth noticing that a great deal of interest has recently been paid by the financial literature with respect to the relationship prevailing between the information asymmetry and the financing decisions regarding 150 firms listed on the SBF 250 index over the period ranging from 2005 to 2012. The achieved estimation results have revealed that most variables turn out to be significantly correlated with financial leverage. This significant correlation is established not only starting from a static model estimated by OLS, taking into account the fixed individual specificities, but also by relying a dynamic model estimated by GMM in difference explaining the leverage variation by its last variation. These results prove to be so conclusive as to corroborate the variables relevance thesis as pertaining to the hierarchical financing theory. Indeed, they have turned out to reveal that French firms tend to resort more to debt above all with respect to the information asymmetry case as prevailing as between managers and investors.
Psychiatric Illness in Women: A Review of the Function of a Specialist Mother-Baby Unit

Objective: The aim of this paper is to describe a specialist program in a psychiatric mother-baby unit and to review the characteristics (including mothering skills) and outcomes on discharge of 36 women consecutively admitted to the unit over an intensive 6-month observation period. Changes in admissions to the same unit over 10 years were also compared. Method: Consecutive admissions were studied in terms of demographics, ethnicity, diagnosis, psychiatric history, psychiatric information and mother-infant data. Results: The majority of women admitted suffered from schizophrenia or other psychotic disorders, with the second largest diagnostic criteria being depression. For 20 mothers, this was the first psychiatric admission and most admissions were voluntary. The mean length of stay was 21.7 days, representing a highly significant decrease in stay when compared to the past 10 years in the same unit. Mothering skills were found to be incompetent or only passable in 57% of women. A small improvement occurred by discharge, and the majority of women were not separated from their infants. Conclusions: The critical need to support these women and their infants in the long term was highlighted, with recommendations of outpatient and day programs, as well as supported accommodation.
Implant Treatments for Edentulous Maxilla With Anterior Hyperfunction.

M astication tends to shift to the anterior regions that are not designed for a heavy occlusal load biomechanically after the loss of established posterior occlusal contacts. In many cases, the presence of excessive anterior occlusal function by anterior mandibular teeth leads to the progressive collapse or the loss of residual anterior teeth in the maxilla. This occlusal trauma also causes significant maxillary anterior alveolar resorption in a patient with a completely edentulous maxilla and a partially edentulous mandible with preserved anterior teeth and is known as ‘‘anterior hyperfunction. ’’ This hyperfunction causes some specific oral changes such as bone loss in the maxillary anterior ridge and palatal papillary hyperplasia, which were defined as combination syndrome (CS) by Kelly in 1972. To avoid and manage anterior hyperfunction and CS, implantretained or implant-supported prostheses have become a popular and successful prosthetic rehabilitation for partially and fully edentulous patients. Furthermore, the timing of clinical decision-making for implant treatment might determine the therapeutic regimens and the difficulty of the treatment. The present article was designed to present the successful implant treatment procedures for 3 anterior hyperfunction patients, each classified into pre-CS, moderate CS, and severe CS and discuss the preventive and manageable therapies for anterior hyperfunction and CS.
Small Molecule Therapeutics Preclinical Evaluation of the WEE 1 Inhibitor MK-1775 as Single-Agent Anticancer Therapy

Inhibitionof theDNAdamage checkpoint kinaseWEE1potentiates genotoxic chemotherapies byabrogating cell-cycle arrest and proper DNA repair. However, WEE1 is also essential for unperturbed cell division in the absence of extrinsic insult. Here, we investigate the anticancer potential of a WEE1 inhibitor, independent of chemotherapy, and explore a possible cellular context underlying sensitivity toWEE1 inhibition.We show that MK-1775, a potent and selectiveATP-competitive inhibitor ofWEE1, is cytotoxic across a broad panel of tumor cell lines and induces DNA double-strand breaks. MK-1775–induced DNA damage occurs without added chemotherapy or radiation in S-phase cells and relies on active DNA replication. At tolerated doses, MK-1775 treatment leads to xenograft tumor growth inhibition or regression. To begin addressing potential response markers for MK-1775 monotherapy, we focused on PKMYT1, a kinase functionally related to WEE1. Knockdown of PKMYT1 lowers the EC50 of MK-1775 by five-fold but has no effect on the cell-based response to other cytotoxic drugs. In addition, knockdown of PKMYT1 increases markers of DNA damage, gH2AX and pCHK1, induced by MK-1775. In a post hoc analysis of 305 cell lines treated with MK-1775, we found that expression of PKMYT1 was below average in 73% of the 33 most sensitive cell lines. Our findings provide rationale for WEE1 inhibition as a potent anticancer therapy independent of a genotoxic partner and suggest that lowPKMYT1 expression could serve as an enrichment biomarker forMK-1775 sensitivity.MolCancer Ther; 12(8); 1442–52. 2013 AACR.
On the magnetic structure of Sr3Ir2O7: an x-ray resonant scattering study

This report presents azimuthal dependent and polarization dependent x-ray resonant magnetic scattering at the Ir L3 edge for the bilayered iridate compound Sr3Ir2O7. The two magnetic wave vectors, and , result in domains of two symmetry-related G-type antiferromagnetic structures, denoted A and B, respectively. These domains are approximately 0.02 mm2 and are independent of the thermal history. An understanding of this key aspect of the magnetism is necessary for an overall picture of the magnetic behaviour in this compound. The azimuthal and polarization dependence of the magnetic reflections, relating to both magnetic wavevectors, show that the Ir magnetic moments in the bilayer compound are oriented along the c axis. This contrasts with single layer Sr2IrO4 where the moments are confined to the ab plane.
Arginine and nitric oxide metabolism in critically ill septic pediatric patients*

ObjectiveTo investigate whole body, in vivo arginine metabolism and nitric oxide synthesis rates in septic, critically ill pediatric patients. DesignProspective study. SettingPediatric intensive care unit at a general hospital. PatientsTen consecutive septic patients age 6–16 yrs. InterventionsSeptic patients received an 8-hr primed, constant intravenous tracer infusion of l-[guanidino-15N2]arginine, l-[1-13C]leucine, and [13C]urea. A 24-hr urine collection was obtained for determination of [15N]nitrate enrichment (15NO3−) and urinary nitrogen. The next day they received an infusion of l-[5-13C]arginine and l-[5-13C-ureido, 5,5,2H2]citrulline. Blood samples were obtained for determination of plasma isotopic enrichment of the tracers given and of derived [15N]citrulline (nitric oxide synthesis), l-[13C-guanidino 5,5, 2H2]arginine (M+3 arg) (arginine synthesis), and [15N2]urea (urea formation). Data are compared with historic controls from studies in healthy young adults. Measurements and Main ResultsPlasma arginine fluxes were 67 ± 21 and 72 ± 17 &mgr;mol·kg−1·hr−1, respectively, for the [15N2 guanidino] and the [13C] arginine labels, which were not different from reported adult values. The rates of arginine oxidation were 22.9 ± 10.8 &mgr;mol·kg−1·hr−1 and were higher than de novo arginine synthesis rates of 9.6 ± 4.2 &mgr;mol·kg−1·hr−1 (p < .01); therefore, these patients were in a negative arginine balance. The rates of nitric oxide synthesis as estimated by the [15N]citrulline method were 1.58 ± 0.69 &mgr;mol·kg−1·hr−1 for septic patients and higher (p < .05) than values of 0.96 ± 0.1 &mgr;mol·kg−1·hr−1 in healthy adults. Septic patients were in a negative protein (leucine) balance of about −1.00 ± 0.40 g·kg−1·day−1. ConclusionsHomeostasis of plasma arginine in septic patients was impaired compared with reported adult values. The rates of arginine oxidation were increased whereas de novo net arginine synthesis was unchanged, leading to a negative arginine balance. The rates of nitric oxide synthesis and the fraction of plasma arginine used for nitric oxide and urea formation were increased. These findings suggest that under condition of sepsis, arginine becomes essential in critically ill children.
Are Malaysian government-linked companies (GLCs) creating value?

Government-linked companies (GLCs) play an important role in the development of the Malaysian economy. However, overall public perception of GLCs in Malaysia has been tainted by the poor performance of key players, namely Malaysia Airline System (MAS) and Proton Holdings Berhad. Results of prior studies on the extent to which government intervention affects a company’s performance are mixed. This study empirically assesses the impact of government intervention on firm value in the context of the Malaysian economy. Results of statistical analysis conducted on 15 GLCs over six years—i.e. 2000 to 2005—reveal a significant positive relationship between the degree of government ownership and firm value. In other words, this study has found that contrary to the adverse public perception of GLCs in Malaysia, government intervention improves firm value. Results of this study provide preliminary evidence on the effectiveness of the ownership and control structure of Malaysian GLCs in creating firm value. Such findings pave the way for future research on the extent to which the ownership and control structure of Malaysian GLCs can serve as a model for developing and third-world countries to emulate.
Influence of soil characteristics and formulation on alachlor dissipation in soil

Fatima Sopena acknowledges an investigating contract from Junta de Andalucia. This work was supported by MEC (Spanish Ministry of Education and Science), Research Projects REN2003-01509 and AGL 2005-00164, and by Junta de Andalucia, Project P06-FQM-01909.
Antigenic Subclasses of Polytropic Murine Leukemia Virus (MLV) Isolates Reflect Three Distinct Groups of Endogenous Polytropic MLV-Related Sequences in NFS/N Mice

ABSTRACT Polytropic murine leukemia viruses (MLVs) are generated by recombination of ecotropic MLVs with members of a family of endogenous proviruses in mice. Previous studies have indicated that polytropic MLV isolates comprise two mutually exclusive antigenic subclasses, each of which is reactive with one of two monoclonal antibodies termed MAb 516 and Hy 7. A major determinant of the epitopes distinguishing the subclasses mapped to a single amino acid difference in the SU protein. Furthermore, distinctly different populations of the polytropic MLV subclasses are generated upon inoculation of different ecotropic MLVs. Here we have characterized the majority of endogenous polytropic MLV-related proviruses of NFS/N mice. Most of the proviruses contain intact sequences encoding the receptor-binding region of the SU protein and could be distinguished by sequence heterogeneity within that region. We found that the endogenous proviruses comprise two major groups that encode the major determinant for Hy 7 or MAb 516 reactivity. The Hy 7-reactive proviruses correspond to previously identified polytropic proviruses, while the 516-reactive proviruses comprise the modified polytropic proviruses as well as a third group of polytropic MLV-related proviruses that exhibit distinct structural features. Phylogenetic analyses indicate that the latter proviruses reflect features of phylogenetic intermediates linking xenotropic MLVs to the polytropic and modified polytropic proviruses. These studies elucidate the relationships of the antigenic subclasses of polytropic MLVs to their endogenous counterparts, identify a new group of endogenous proviruses, and identify distinguishing characteristics of the proviruses that should facilitate a more precise description of their expression in mice and their participation in recombination to generate recombinant viruses.
Artificial Nerve Graft Using Collagen as an Extracellular Matrix for Nerve Repair Compared with Sutured Autograft in a Rat Model

A study was conducted to compare the regeneration of rat peroneal nerves across 0.5-cm gaps repaired with artificial nerve grafts versus sutured autografts. The artificial nerve graft model is composed of a synthetic biodegradable passive conduit made of polyglycolic acid filled with a collagen extracellular matrix (predominately Type I collagen, derived from calf skin, and with the telopeptide ends left intact). Axonal regeneration was studied in 22 long-term animals (11 or 12 months). The nerves were studied by qualitative and quantitative histological and electrophysiological methods, and by functional analysis in 9 of the animals. The axonal regeneration of the artificial nerve graft is equal to sutured autografts as measured by axonal counts, and by physiological and functional methods, although the sutured autografts demonstrated statistically superior axonal diameters.
GABA distribution in lamprey is phylogenetically conserved

The localization of γ‐aminobutyric acid (GABA) has been well described in most classes of vertebrates but not in adult lampreys. The question if the GABA distribution is similar throughout the vertebrate subphylum is therefore still to be addressed. We here investigate two lamprey species, the sea lamprey, Petromyzon marinus, and the river lamprey, Lampetra fluviatilis, and compare the GABA pattern with that of other vertebrates. The present immunohistochemical study provides an anatomical basis for the general distribution and precise localization of GABAergic neurons in the adult lamprey forebrain and brainstem. GABA‐immunoreactive cells were organized in a virtually identical manner in the two species. They were found throughout the brain, with the following regions being of particular interest: the granular cell layer of the olfactory bulb, the nucleus of the anterior commissure, the septum, the lateral and medial pallia, the striatum, the nucleus of the postoptic commissure, the thalamus, the hypothalamus, and pretectal areas, the optic tectum, the torus semicircularis, the mesencephalic tegmentum, restricted regions of the rhombencephalic tegmentum, the octavolateral area, and the dorsal column nucleus. The GABA distribution found in cyclostomes is very similar to that of other classes of vertebrates, including mammals. Since the lamprey diverged from the main vertebrate line around 450 million years ago, this implies that already at that time the basic vertebrate plan for the GABA innervation in different parts of the brain had been developed. J. Comp. Neurol. 503:47–63, 2007. © 2007 Wiley‐Liss, Inc.
In-depth Investigation of Hf-based High-k Dielectrics as Storage Layer of Charge-Trap NVMs

In this paper, different Hf-based oxides (HfO2, HfSiO under several annealing conditions, HfSiON, HfAlO with various compositions) are simultaneously considered as storage layers of charge-trap memories. Based on material characterization analyses, electrical data of memory cells, physical modeling of charge-trap devices, we show that a strict relationship exists between the crystal structure of the storage layer and the memory performances. The obtained results clearly demonstrate the high interest of HfO2 dielectric as possible storage layer of future NROM-like memory devices
Outdoor and indoor experiments with localization using LTE signals

This paper reports experiments with realistic positioning using LTE downlink signals measurements. Sets of real live samples of LTE signals have been gathered during outdoor and indoor acquisitions in the town of Rapperswil, Switzerland. The collected data is then processed using a Super Resolution Algorithm in order to extract the received LTE cell specific reference signals, which are used to estimate the pseudoranges. Both an Extended Kalman Filter and an Iterative Least Squares algorithm are evaluated for processing the pseudoranges to obtain the location and time. The algorithms are compared and their different applications are discussed. The features and limitations of LTE signals and networks are also discussed and their impact on positioning performance assessed. The results show that positioning using LTE signals can achieve remarkable performance (50% error quantile as low as 6 m), and that their use is potentially suitable for indoor as well as outdoor applications.
Near Normalisation of Lumbar Spine Bone Density in Young Women with Osteopenia Recovered from Adolescent Onset Anorexia Nervosa: A Longitudinal Study

To investigate the effect of the progression of adolescent onset anorexia nervosa (AN) on bone parameters we followed two cohorts (Disease cohort and recovered cohort) of adolescents for a total of 5.2 years. In the 'Disease' cohort (n = 18), lumbar spine bone density (BMD) was reduced by 0.6 SD after 0.8 years of disease and was reduced a further 1.0 SD after a total 2.5 years of disease (p < 0.001). At the third lumbar vertebra there was bone loss (-3.7%, p < 0.05) resulting in reduced volumetric BMD (-5.1%, p < 0.08). In the 'recovered' cohort, lumbar spine BMD was reduced by 1.9 SD after 1.7 years of disease, and increased by 1.5 SD after 2.7 years of recovery (p < 0.001). At the third lumbar vertebra there was an increase in bone mass (20.5%, p < 0.001) and bone volume (14.1%, p < 0.001), resulting in increased volumetric BMD (6.3%, p < 0.08). Normalisation of lumbar spine BMD may be achieved in patients with adolescent onset AN when the successful recovery of body weight is combined with the return of regular menses.
Fast activation of feedforward inhibitory neurons from thalamic input and its relevance to the regulation of spike sequences in the barrel cortex

Thalamocortical afferents innervate both excitatory and inhibitory cells, the latter in turn producing disynaptic feedforward inhibition, thus creating fast excitation–inhibition sequences in the cortical cells. Since this inhibition is disynaptic, the time lag of the excitation–inhibition sequence could be ∼2–3 ms, while it is often as short as only slightly above 1 ms; the mechanism and function of such fast IPSPs are not fully understood. Here we show that thalamic activation of inhibitory neurons precedes that of excitatory neurons, due to increased conduction velocity of thalamic axons innervating inhibitory cells. Developmentally, such latency differences were seen only after the end of the second postnatal week, prior to the completion of myelination of the thalamocortical afferent. Furthermore, destroying myelination failed to extinguish the latency difference. Instead, axons innervating inhibitory cells had consistently lower threshold, indicating they had larger diameter, which is likely to underlie the differential conduction velocity. Since faster activation of GABAergic neurons from the thalamus can not only curtail monosynaptic EPSPs but also make disynaptic ISPSs precede disynaptic EPSPs, such suppression theoretically enables a temporal separation of thalamically driven mono‐ and disynaptic EPSPs, resulting in spike sequences of ‘L4 leading L2/3’. By recording L4 and L2/3 cells simultaneously, we found that suppression of IPSPs could lead to deterioration of spike sequences. Thus, from the end of the second postnatal week, by activating GABAergic neurons prior to excitatory neurons from the thalamus, fast feedforward disynaptic suppression on postsynaptic cells may play a role in establishing the spike sequences of ‘L4 leading L2/3 cells’.
The WISC-III Freedom from Distractibility Factor: Its Utility in Identifying Children with Attention Deficit Hyperactivity Disorder.

Factor analytic studies of the Wechsler Intelligence Scale for Children—Revised (WISC–R; Wechsler, 1974) have consistently identified what is commonly known as the Freedom From Distractibility (FFD) factor, consisting of the Arithmetic, Digit Span, and Coding subtests (Kaufman, 1979). Support for the validity of this factor stems in part from studies that found significant correlations between the WISC–R FFD subtests and other established measures of attention, such as Continuous Performance Tests (Klee & Garfinkel, 1983) and teacher ratings (Reschly & Reschly, 1979). Additional support comes from investigations that detected significantly lower FFD scores among groups of children with attention deficit hyperactivity disorder (ADHD; American Psychiatric Association, 1987) in comparison with control children (Lufi, Cohen, & Parish-Plass, 1990).
Possible windborne spread of bluetongue to Portugal, June–July 1956

Summary The possible sources for the epidemic of bluetongue in Portugal at the beginning of July 1956 were examined. Introduction through authorized importation of domestic or wild ruminants was not feasible, since no cattle, sheep or goats were imported and the wild ruminants were confined to Lisbon Zoo, which was too far from the initial outbreaks. Weather maps were examined to see if the wind could have carried infected Culicoides midges from North Africa. On 21 June 1956 infected midges in Morocco could have been taken offshore by southeast winds and then carried by south winds unusual at that time of year to the south coast of Portugal. The 200–300 km sea crossing would have taken some 10 h and been by day when air temperatures near the sea surface were about 18–20 °C. Bluetongue had not been reported at that time in Morocco, and the possibility of the presence of the virus in Moroccan animals without clinical signs is discussed.