Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficacy of Methotrexate Treatment in Children with Polyarticular Juvenile Idiopathic Arthritis

Objective: This study aims to evaluate the efficacy of methotrexate (MTX) use in the treatment of patients with polyarticular Juvenile Idiopathic Arthritis (JIA). Materials and Methods: Forty-nine patients with polyarticular JIA who didn’t respond to NSAIDs and therefore underwent the MTX treatment were analyzed retrospectively. The joint involvements were evaluated through systemic and extra-articular findings while the laboratory findings were assessed in terms of remission, deformity, and relapse rates. Results: Twenty-eight patients with polyarticular JIA received MTX therapy. The majority of our MTX patients ages (46.4%) ranged between 8–11 years. While 18 patients were girls, 10 were boys. The most frequent joint involvements were observed in knee, ankle, wrist, and finger. Extra-articular findings were observed in 17 patients. The laboratory findings highlighted that; increase in C-reactive protein (CRP) 25 (92.5%), leukocytosis 2 (7.1%), thrombocytosis 21 (75%) and anemia 22 (78.5%) were observed in patients. The remission rate of the patients with MTX treatment at regular controls was 83.3%, the deformity rate 20.8% and the relapse rate was 45.8%. Conclusion: MTX treatment is successful for patients with polyarthritis-induced JIA with poor prognostic factors, not having responded to NSAIDs.
Seiberg-Witten invariant and Casson-Walker invariant for rational homology 3-spheres

We consider a modi ed version of the Seiberg{Witten invariants for rational homology 3{spheres, obtained by adding to the original invariants a correction term which is a combination of {invariants. We show that these modi ed invariants are topological invariants. We prove that an averaged version of these modi ed invariants equals the Casson{Walker invariant. In particular, this result proves an averaged version of a conjecture of Ozsv ath and Szab o on the equivalence between their ̂ invariant and the Seiberg{Witten invariant of rational homology 3{spheres.
Delamination of southern Puna lithosphere revealed by body wave attenuation tomography

The southern Puna Plateau has been proposed to result from a major Pliocene delamination event that has previously been inferred from geochemical, geological, and some preliminary geophysical data. Seventy‐five seismic stations were deployed across the southern Puna Plateau in 2007–2009 by scientists from the U.S., Germany, Chile, and Argentina to test the delamination model for the region. The Puna passive seismic stations were located between 25 and 28°S. Using the seismic waveform data collected from the PUNA experiment, we employ attenuation tomography methods to resolve both compressional and shear quality factors (Qp and Qs, respectively) in the crust and uppermost mantle. The images clearly show a high‐Q Nazca slab subducting eastward beneath the Puna plateau and another high‐Q block with a westward dip beneath the Eastern Cordillera. We suggest that the latter is a piece of delaminated South American lithosphere. A significant low‐Q zone lies between the Nazca slab and the South American lithosphere and extends southward from the northern margin of the seismic array at 25°S before vanishing around 27.5°S. This low‐Q zone extends farther west in the crust and uppermost mantle at the southern end of the seismic array. The low‐Q zone reaches ~100 km depth beneath the northern part of the array but only ~50 km depth in the south. Lateral variations of the low‐Q zone reflect the possible mechanism conversion between mantle upwelling related to delamination and dehydration. The depth of the Nazca slab as defined by Q images decreases from north to south beneath the plateau, which is consistent with the steep‐flat transition of the angle of the subducting slab as defined by previous earthquake studies.
Ventilatory Acclimatization in Women to High Altitude

Abstract : The purpose of this study was to test the hypotheses that women ascending to high altitude in their early luteal phase will have higher resting ventilations and accelerated ventilatory acclimatization compared to women in their follicular phase. Furthermore, given the proportionally greater ventilation in women compared to men, we postulated that women will have higher resting ventilations and accelerated ventilatory, acclimatization compared to men at the same altitude.
Plan and Goal Recognition as HTN Planning

Plan-and Goal Recognition (PGR) is the task of inferring the goals and plans of an agent based on its actions. Traditional approaches in PGR are based on a plan library including pairs of plans and corresponding goals. In recent years, the field successfully exploited the performance of planning systems for PGR. The main benefits are the presence of efficient solvers and well-established, compact formalisms for behavior representation. However, the expressivity of the STRIPS planning models used so far is limited, and models in PGR are often structured in a hierarchical way. We present the approach Plan and Goal Recognition as HTN Planning that combines the expressive but still compact grammar-like HTN representation with the advantage of using unmodified, off-the-shelf planning systems for PGR. Our evaluation shows that - using our approach - current planning systems are able to handle large models with thousands of possible goals, that the approach results in high recognition rates, and that it works even when the environment is partially observable, i.e., if the observer might miss observations.
Nonaliquots and Robbins numbers

Let '(·) and �(·) denote the Euler function and the sum of divisors func- tion, respectively. We give a lower bound for the number of mx for which the equation m = �(n) n has no solution. We also show that the set of positive integers m not of the form (p 1)/2 '(p 1) for some prime number p has a positive lower asymptotic density.
A STUDY OF THE USE OF PERCEPTUAL FEATURES FOR MUSIC EMOTION RECOGNITION

Perceptual features are defined as musical descriptors that closely match a listener’s understanding of musical characteristics. This paper tackles Music Emotion Recognition through the consideration of three kinds of perceptual feature sets, human rated, computational and modelled features. The human rated features are extracted through a survey and the computational features are estimated directly from the audio signal. Regressive modelling is used to predict the human rated features from the computational features. The latter predicted set constitute the modelled features. The regressive models performed well for all features except for Harmony, Timbre and Melody. All three feature sets are used to train three regression models (one for each set) to predict the components Energy and Valence, which are then used to recognise emotion. The model trained on the rated features performed well for both components. This therefore shows that emotion can be predicted from perceptual features. The models trained on the computational and modelled features performed well in predicting Energy, but not so well in predicting Valence. This is not surprising since the main predictors for Valence are Melody, Harmony and Timbre, which therefore need added or modified computational features that better match human perception.
On Gerber–Shiu functions and optimal dividend distribution for a Lévy risk process in the presence of a penalty function

This paper concerns an optimal dividend distribution problem for an insurance company whose risk process evolves as a spectrally negative L\'{e}vy process (in the absence of dividend payments). The management of the company is assumed to control timing and size of dividend payments. The objective is to maximize the sum of the expected cumulative discounted dividend payments received until the moment of ruin and a penalty payment at the moment of ruin, which is an increasing function of the size of the shortfall at ruin; in addition, there may be a fixed cost for taking out dividends. A complete solution is presented to the corresponding stochastic control problem. It is established that the value-function is the unique stochastic solution and the pointwise smallest stochastic supersolution of the associated HJB equation. Furthermore, a necessary and sufficient condition is identified for optimality of a single dividend-band strategy, in terms of a particular Gerber-Shiu function. A number of concrete examples are analyzed.
Metallurgical Factors Influencing the Machinability of Inconel 718

Because of the large volume of Inconel 718 used by the aerospace and power generation industries and the high percentage of metal removed to machine complex component geometries; understanding and improving the machining characteristics of Inconel 718 would result in substantial cost savings. While progress has been made in developing improved tool materials and machining processes, a detailed understanding of the metallurgical factors influencing the machinability of Inconel 718 has not been generated. This paper presents work conducted by United Technologies Research Center and Pratt & Whitney Division establishing the relationship between the metallurgy and machinability of Inconel7 18. Factors such as fabrication technique (investment cast, cast + HIP and wrought), hardness, grain size and carbon content were all found to influence machinability. In addition to presenting the relationship between metallurgy and machinability of Inconel 718, suggestions are made in order to improve Inconel 718 machining characteristics and reduce fabrication costs. Superalloys 718,625,706 and Various Derivatives Edited by E.A. Loria The Minerals, Metals &Materials Society, 1994
Synthetic and Marine-Derived Porous Bone Graft Substitutes

Bone is a dynamic tissue with the capacity of repair and regeneration in specific conditions. Nevertheless, due to the increased incidence of bone disorders, the need of bone grafts has been growing over the past decades and the development of an ideal bone graft with optimal properties remains a clinical challenge. This review addresses the bone properties (morphology, composition and their repair and regeneration capacity) and puts the main focus on the potential strategies for developing bone repair and regeneration materials. It describes the requirements for designing a suitable scaffold material, types of materials (polymers, ceramics and composites) and techniques to obtain the porous structures (additive manufacturing techniques/robocasting or derived from marine skeletons) for bone tissue engineering applications. The main objective of this review is to gather the knowledge on the materials and methods for the production of scaffolds for bone tissue engineering and highlighting the potential of natural porous structures such as marine skeletons as promising alternative bone graft substitute materials without any further mineralogical changes, or after partial or total transformation into calcium phosphate. The suitability of the marine-derived porous bone graft substitutes for the intended applications will be also discussed.
Running head: RELATION BETWEEN TEAM CONFIDENCE AND PERFORMANCE

26 The present manuscript extends previous research on the reciprocal relation between 27 team confidence and perceived team performance in two ways. First, we distinguished 28 between two types of team confidence; process-oriented collective efficacy and outcome29 oriented team outcome confidence. Second, we assessed both types not only before and after 30 the game, but for the first time also during half-time, thereby providing deeper insight into 31 their dynamic relation with perceived team performance. Two field studies were conducted, 32 each with 10 male soccer teams (N = 134 in Study 1; N = 125 in Study 2). Our findings 33 provide partial support for the reciprocal relation between players‟ team confidence (both 34 collective efficacy and team outcome confidence) and players‟ perceptions of the team‟s 35 performance. Although both types of players‟ team confidence before the game were not 36 significantly related to perceived team performance in the first half, players‟ team confidence 37 during half-time was positively related to perceived team performance in the second half. 38 Additionally, our findings consistently demonstrated a relation between perceived team 39 performance and players‟ subsequent team confidence. Considering that team confidence is a 40 dynamical process, which can be affected by coaches and players, our findings open new 41 avenues to optimize team performance. 42
Metabolic remodeling of the tumor microenvironment: migration stimulating factor (MSF) reprograms myofibroblasts toward lactate production, fueling anabolic tumor growth

Recommended Cit tio Carito, Valentina; Bonuccelli, Gloria; Martinez-Outschoorn, Ubaldo E; Whitaker-Menezes, Diana; Caroleo, Maria Cristina; Cione, Erika; Howell, Anthony; Pestell, Richard G; Lisanti, Michael P.; and Sotgia, Federica, "Metabolic remodeling of the tumor microenvironment: migration stimulating factor (MSF) reprograms myofibroblasts toward lactate production, fueling anabolic tumor growth. " (2012). Department of Stem Cell Biology and Regenerative Medicine Faculty Papers & Presentations. Paper 8. https://jdc.jefferson. edu/stem_regenerativefp/8
U . S . State Fiscal Policy and Natural Resources

An analytical framework predicts that, in response to an exogenous increase in resource-based government revenue, a benevolent government will partially substitute away from taxing income, increase spending and save. Fifty-one years of U.S.-state level data are largely consistent with this theory. A baseline fixed effects model predicts that a $1.00 increase in resource revenue results in a $0.25 decrease in non-resource revenue, a $0.43 increase in spending and a $0.32 increase in savings. Instrumenting for resource revenue reveals that a positive revenue shock is largely saved and the rest is transferred back to residents in the form of lower non-resource tax rates. JEL: Q38; H20
Homeobox Genes Mediates the Biological Functions of Human TITLE: Chorionic Gonadotropin (hCG) in Human Breast Epithelial Cells

GRANT NUMBER: DAMD17-99-1-9182 Homeobox Genes Mediates the Biological Functions of Human TITLE: Chorionic Gonadotropin (hCG) in Human Breast Epithelial Cells PRINCIPAL INVESTIGATOR: Jose Russo, M.D. CONTRACTING ORGANIZATION: Fox Chase Cancer Center Philadelphia, Pennsylvania 19111 REPORT DATE: July 2000 TYPE OF REPORT: Annual PREPARED FOR: U.S. Army Medical Research and Material Command Fort Detrick, Maryland 21702-5012
Memory Architectures in Recurrent Neural Network Language Models

We compare and analyze sequential, random access, and stack memory architectures for recurrent neural network language models. Our experiments on the Penn Treebank and Wikitext-2 datasets show that stack-based memory architectures consistently achieve the best performance in terms of held out perplexity. We also propose a generalization to existing continuous stack models (Joulin & Mikolov,2015; Grefenstette et al., 2015) to allow a variable number of pop operations more naturally that further improves performance. We further evaluate these language models in terms of their ability to capture non-local syntactic dependencies on a subject-verb agreement dataset (Linzen et al., 2016) and establish new state of the art results using memory augmented language models. Our results demonstrate the value of stack-structured memory for explaining the distribution of words in natural language, in line with linguistic theories claiming a context-free backbone for natural language.
UNOFFICIAL ECONOMY IN CROATIA: ESTIMATION METHODS AND RESULTS

According to the Eurostat’s recommendations, GDP of each country must be as exhaustive as possible regarding economic activity coverage. All EU member states and candidate countries have a strict obligation to include the estimate of the unoffi cial economy (UE) in offi cial GDP data. Over the past few years, the Croatian Bureau of Statistics (CBS) has been working on a project of improvement the exhaustiveness of national accounts. Recently, offi cial national accounts data have been revised, thus expanding coverage to include the estimated unoffi cial economy.
Prevalence of Human Immune Deficiency among Registered Tuberculosis Patients across Pakistan during 2013-2015—Prevalence of TB-HIV Co-Infection in Pakistan

The problem of Tuberculosis (TB) and Human Immune Deficiency Virus (HIV) co-infection becomes vital when it is seen in the context of under developed countries like Pakistan. Pakistan ranks 5th high burden countries for drug-susceptible and 6th among drug-resistant TB patients [1]. Objectives of the study were to assess the prevalence of TB-HIV Co-infection at the designated Sentinel Sites across Pakistan. A cross-sectional study is based on retrospective record review of routinely maintained TB program data at all 17 designated sentinel sites of TB Control Program from 2013-15. Among the screened TB patients 145 (0.66%) were found HIV reactive. The prevalence of HIV was higher (1.02%) in extra-pulmonary and male TB patients (1.23 %) as compared to pulmonary (0.55%) and female patients (0.09%). Scale up TB surveillance activities, integrating TB-HIV care services, active case finding among key affected populations will have a positive impact on TB-HIV co-infection and disease control.
Iterative methods for solving partial difference equations of elliptic type

Conditions (1.2) were formulated by Geiringer [4, p. 379](2). Evidently these conditions imply that ai,i 5#O (i=1, 2, -, 1N). It is easy to show by methods similar to those used in [4, pp. 379-381] that the determinant of the matrix A= (ai,j) does not vanish. Moreover, if the matrix A * = (a*j) is symmetric, where a*1=ai,iai,j/ ai,i (i, j= 1, 2, N * , N), then A * is positive definite. For if X is a nonpositive real number, then the matrix A * -XI, where I is the identity matrix, also satisfies (1.2) and hence its determinant cannot vanish. Therefore all eigenvalues of A * are positive, and A * is positive definite. On the other hand if A* is positive definite then ai,i5zQ (i=1, 2, , N). We shall be concerned with effective methods for obtaining numerical solu-
Sex Determination by CHDW and CHDZ Genes of Avian Sex Chromosomes in Nymphicus hollandicus

The aim of this study was sex determination in Nymphicus hollandicus without giving it any harm and obtaining accurate results by DNA analysis. CHD genes are preserved within avian Z and W sex chromosomes. The intron regions of the CHDW and CHDZ genes vary between male (ZZ) and female (ZW) individuals. The method used in this study was based on this difference. DNA was extracted from feathers instead of blood. The intron regions of CHDW and CHDZ genes were amplified by sex specific primers (P2 and P8). PCR products were screened by agarose gel electrophoresis. Individuals showing double (ZW) and single (ZZ) bands were identified as females and males, respectively. Ozet: Bu cal›flman›n amac›, Nymphicus hollandicus'lara (sultan papaan›) fiziksel bir zarar vermeden DNA analiz metoduyla cinsiyet saptamas› yapmakt›r. CHD genleri kanatl› Z ve W cinsiyet kromozomlar› aras›nda korunmufltur. CHD geninin intron bolgesi erkek (ZZ) ve difli (ZW) bireyler aras›nda farkl›l›k gostermektedir. Cal›flmada kullan›lan metotta bu farkl›l›k esas al›nm›flt›r. DNA kan yerine tuyden izole edilmifltir. PCR uygulamas› CHDW ve CHDZ genlerinin intron bolgesini coaltan cinsiyete ozel primerler kullan›larak (P2 ve P8) gerceklefltirilmifltir. PCR urunleri agaroz jel elektroforezi ile goruntulenmifltir. Sonuc olarak, cift bant gosterenlerin difli, tek bant gosterenlerin erkek olduu saptanm›flt›r. Anahtar Sozcukler: Nymphicus hollandicus, CHD1W, CHD1Z, kanatl›, cinsiyet tayini
Annual AIAA/USU Conference on Small Satellites Drift Recovery and Station Keeping Results for the Historic CanX-4/CanX-5 Formation Flying Mission

Specialized drift recovery and station keeping algorithms were developed for the Canadian Advanced Nanospace eXperiments 4 and 5 (CanX-4 & CanX-5) formation flying mission (launched 30 June 2014), and successfully verified on orbit. These algorithms performed almost exactly according to predictions. The highly successful CanX4 and CanX-5 formation flying demonstration mission was completed in November 2014, ahead of schedule. CanX-4 & CanX-5 are a pair of identical formation flying nanosatellites that demonstrated autonomous submetre formation control, with relative position knowledge of better than 10 cm and control accuracy of less than one metre at ranges of 1000 to 50 metres. This level of performance has never before been seen on nanosatellite class spacecraft to the author’s knowledge. This capability is crucial to the future use of coordinated small satellites in applications such as sparse aperture sensing, interferometry, ground moving target indication, on-orbit servicing or inspection of other spacecraft, and gravitational and magnetic field science. Groups of small, relatively simple spacecraft can also replace a single large and complex one, reducing risk through distribution of smaller instruments, and saving money by leveraging non-recurring engineering costs. To facilitate the autonomous formation flight mission, it was a necessary precondition that the two spacecraft be initially brought within a few kilometres of one another, with a low relative velocity. Complicating this was the fact that the CanX-4 and CanX-5 spacecraft were released separately from their shared launch vehicle, drifting thousands of kilometres apart in the short time it took to fully commission one spacecraft. Therefore, a system to calculate fuelefficient recovery trajectories and produce the corresponding spacecraft commands was required, another first on the nanosatellite scale. This system was also extended to provide station keeping capabilities in the time between individual formation experiments, to keep the spacecraft safely separated without allowing their distance to grow large again.
THREE-DIMENSIONAL COMPRESSIONAL- AND SHEAR-WAVE SEISMIC VELOCITY MODELS FOR THE SOUTHEAST GEYSERS GEOTHERMAL FIELD, CALIFORNIA

Three-dimensional compressionaland shear-wave velocity (“Vp” and “Vs,” respectively) structure is obtained for the SE Geysers geothermal area from microearthquake arrival-time data. The results indicate a region of high Vp and high Vs in the northwest portion of the area studied, and a low value of VpNs at depths corresponding to the upper part of the steam reservoir. The Vp and Vs anomalies are found to be well-modeled by the predicted seismic signature of the felsite intrusion.
Antinutrients in the cassava (Manihot esculenta Crantz) leaf powder at three ages of the plant

In Brazil, the cassava leaf meal (CLM) has been used to strive against undernourishment because it is a high source of vitamins and minerals. However, the wide variation in the chemical composition of the different cultivars, as well as their antinutritional substances may be a restriction to their uses. The levels of some antinutrients in CLM from five cultivars at three ages of the plant (TAP) were investigated, in order to select the cultivars and plant ages that would be more appropriate for human consumption. The lowest contents of antinutrients were observed in the 12-month old plants, except for nitrate and hemagglutinin from which the lowest contents were found for the 17 month old ones. The cultivar IAC 289-70 had the lowest antinutrient levels, except for saponin and oxalate. Thus, the cultivar IAC 289-70 at 12 months is the most appropriate for human consumption.