Miracle-dz/UniFAR-FTUs huggingface dataset:
The Metallo-β-lactamase GOB Is a Mono-Zn(II) Enzyme with a Novel Active Site*

Metallo-β-lactamases (MβLs) are zinc-dependent enzymes able to hydrolyze and inactivate most β-lactam antibiotics. The large diversity of active site structures and metal content among MβLs from different sources has limited the design of a pan-MβL inhibitor. Here we report the biochemical and biophysical characterization of a novel MβL, GOB-18, from a clinical isolate of a Gram-negative opportunistic pathogen, Elizabethkingia meningoseptica. Different spectroscopic techniques, three-dimensional modeling, and mutagenesis experiments, reveal that the Zn(II) ion is bound to Asp120, His121, His263, and a solvent molecule, i.e. in the canonical Zn2 site of dinuclear MβLs. Contrasting all other related MβLs, GOB-18 is fully active against a broad range of β-lactam substrates using a single Zn(II) ion in this site. These data further enlarge the structural diversity of MβLs.
Cilt: III Sayı:27 Türk Psikolojik Danışma ve Rehberlik Dergisi ÜNİVERSİTE ÖĞRENCİLERİNDE ÖZNEL VE PSİKOLOJİK İYİ OLMANIN

In this study, it has been aimed to determine the rate of how university students’ subjective and psychological well-being are predicted by their level of extraversion, neurouticism, locus of control, learned resourcefulness, socio-economic status, gender, health situations and satisfaction of social interactions, recreation activities and academic conditions. The study was conducted with 500 university students. 205 of whom were female and 295 of whom were male. “Ryff’s Scales of Psychological WellBeing” were used to determine the level of students’ psychological well-being. Similarly; in order to determine their subjective well-being level, both “Positive-Negative Affect Schedule” and “Life Satisfaction Scale” were used. “Scales of Psychological Well-Being” were adapted into Turkish by the researcher in the present study. Additionally, “Eysenck Personality Questionnaire”, “Rotter Internal-External * Yard. Doç. Dr. Çukurova Üniversitesi Eğitim Fakültesi Eğitim Bilimleri Bölümü Psikolojik Danışmanlık ve Rehberlik Anabilim Dalı, Adana ** Prof. Dr. Çukurova Üniversitesi Eğitim Fakültesi Eğitim Bilimleri Bölümü Psikolojik Danışmanık ve Rehberlik Anabilim Dalı, Adana e-posta: fulyac@cu.edu. tr Fulya Cenkseven Turan Akbaş 44 Control Scale” and “Rosenbaum Learned Resourcefulness Inventory” were used. The results of stepwise regression analyses show that the satisfaction with the interaction of friends was not a significant predictor of subjective well-being. But, other variables mentioned explained 63.9 % of the total variance. Besides, as for the results of the stepwise regression analyses, it was revealed that perceived healthiness, socio-economic status and academic achievement did not significantly predict psychological well-being. But, it was observed that other variables explained 59 % of the total variance.
Blood biochemical parameters of Brazilian sport horses under training in tropical climate

ABSTRACT This study aimed to provide baseline data for the serum biochemical parameters of Brazilian sport horses undergoing physical training for eventing to be used as a practical guide. A total of 139 blood samples were collected by vacuum venipuncture of the jugular vein from healthy horses in training. Tubes without anticoagulant were used for biochemical analysis. Means and standard deviations were determined for aspartate aminotransferase (AST) (306.27±84.66 U/L), creatine kinase (CK) (181.06±80.38 U/L), urea (29.51±5.82 mg/dL), creatinine (1.44±0.20 mg/dL), [. ]
Structure and Migration of 2D Vortices

The evolution of 2D vortices is studied in the case of an adiabatic disk. A new vortex model is derived using a gaussian assumption and tested against numerical solutions. This model is compared with previous ones and used as an initial solution for an accurate second order numerical method. Three parameters are necessary to constrain the model: the radial extent of the vortex, its aspect ratio and the local Rossby number. We explore the space of the parameters and find that two dierent families of vortices can be distinguished: (i) large elongated vortices and (ii) small compact vortices. The shape of the vortices is nearly unchanged even after thousands of rotations. We find that 2D vortices migrate inward at a nearly constant rate that depends on the disk parameters and on the vortex aspect ratio. They appear as quasi-steady structures in Keplerian disks.
What Accounts for the Changes in U.S. Fiscal Policy Transmission?

Using vector autoregressions on U.S. time series for 1957-79 and 1983-2004, we find government spending shocks to have stronger effects on output, consumption, and wages in the earlier period. We try to account for this observation within a DSGE model featuring price rigidities and limited asset market participation. Specifically, we estimate the structural parameters of the model for both periods by matching impulse responses. Model-based counterfactual experiments suggest that most of the changes in fiscal policy transmission are accounted for by increased asset market participation and the more active monetary policy of the Volcker-Greenspan period.
Job Creation and Job Destruction in the Theory of Unemployment

In this paper we model a job-specific shock process in the matching model of unemployment with non-cooperative wage behaviour. We obtain endogenous job creation and job destruction processes and study their properties. We show that an aggregate shock induces negative correlation between job creation and job destruction whereas a dispersion shock induces positive correlations. The job destruction process is shown to have more volatile dynamics than the job creation process. In simulations we show that an aggregate shock process proxies reasonably well the cyclical behaviour of job creation and job destruction in the United States.
Effects of salt stress on carbohydrate metabolism in desert soil alga Microcoleus vaginatus Gom.

The effects of salt stress on carbohydrate metabolism in Microcoleus vaginatus Gom. , a cyanobacterium isolated from desert algal crusts, were investigated in the present study. Extracellular total carbohydrates and exopolysaccharides (EPS) in the culture medium produced by M. vaginatus increased significantly during the growth phase and reached a maximum during the stationary phase. The production of extracellular carbohydrates also significantly increased under higher salt concentrations, which was attributed to an increase in low molecular weight carbohydrates. In the presence of NaCl, the production of cellular total carbohydrates decreased and photosynthetic activity was impaired, whereas cellular reducing sugars, water-soluble sugars and sucrose content and sucrose phosphate synthase activity increased, reaching a maximum in the presence of 200 mmol/L NaCl. These parameters were restored to original levels when the algae were transferred to a non-saline medium. Sodium and K+ concentrations of stressed cells decreased significantly and H+-ATPase activity increased after the addition of exogenous sucrose or EPS. The results suggest that EPS and sucrose are synthesized to maintain the cellular osmotic equilibrium between the intra- and extracellular environment, thus protecting algal cells from osmotic damage, which was attributed to the selective exclusion of cellular Na+ and K+ by H+-ATPase.
Effects of freezing on sperm velocity in four different age groups of Jermasia buck.

The present study was undertaken to investigate the effects of freezing on sperm velocity in four different age groups (young: <1 year; mature: e <= 1.0-2.5 years; old: e <= 2.5-4.5 years and very old: e <= 4.5 years) of Jermasia buck. Tris Citric Acid Egg Yolk Extender (TCAYE) was added to semen samples and cryopreserved using a programmable freezer prior to plunging into liquid nitrogen (-196 degrees C). The fresh extended and frozen-thawed semen were subjected to computer automated semen analyzer (CASA) for sperm velocity evaluation. Fresh extended sperm in mature age group showed significantly highest values for average path velocity (VAP) 76.73 +/- 1.24 mu m/s, straight line velocity (VSL) 55.30 +/- 1.05 mu m/s, curvilinear velocity (VCL) 144.31 +/- 2.38 mu m/s, amplitude of lateral head displacement (ALH) 6.59 +/- 0.10 mu m and beat cross frequency (BCF) 39.59 +/- 0.36Hz as compared to young, old and very old age groups of buck (P<0.05). Significantly (P<0.05) higher values for VAP, VSL, VCL and ALH were observed in fresh as compared to frozen-thawed sperm in all age groups of buck. Thus, age of bucks should be considered as one of the factors that contribute to better sperm velocity which might affect fertilizability of the sperm. Optimizing the freezing technique is also essential in order to obtain satisfactory results after artificial insemination.
Modeling with a large class of unimodal multivariate distributions

ABSTRACT In this paper we introduce a new class of multivariate unimodal distributions, motivated by Khintchine's representation for unimodal densities on the real line. We start by introducing a new class of unimodal distributions which can then be naturally extended to higher dimensions, using the multivariate Gaussian copula. Under both univariate and multivariate settings, we provide MCMC algorithms to perform inference about the model parameters and predictive densities. The methodology is illustrated with univariate and bivariate examples, and with variables taken from a real data set.
Are Organic Growers Satisfied with the Certification System? A Causal Analysis of Farmers’ Perceptions in Chile

This study addresses farmer satisfaction with organic certification and its determinants. The findings show that the majority of the interviewees are satisfied with the certification system. Furthermore, the perceived benefit in terms of farm income is the most important factor determining satisfaction, suggesting a need to improve communication of other potential benefits such as market access. The perceived bureaucracy associated with organic certification negatively affects farmers’ expectations, indicating that the simplification of the certification process and harmonisation of organic standards should be considered in the political debate. Surprisingly, the perceived reliability of organic certification has no significant effect on satisfaction. This study discusses market and policy implications.
Potential for Hepa filter damage from water spray systems in filter plenums

The water spray systems in high efficiency particulate air (HEPA) filter plenums that are used in nearly all Department of Energy (DOE) facilities for protection against fire was designed under the assumption that the HEPA filters would not be damaged by the water sprays. The most likely scenario for filter damage involves filter plugging by the water spray, followed by the fan blowing out the filter medium. A number of controlled laboratory tests that were previously conducted in the late 1980s are reviewed in this paper to provide a technical basis for the potential HEPA filter damage by the water spray system in HEPA filter plenums. In addition to the laboratory tests, the scenario for HEPA filter damage during fires has also occurred in the field. Afire in a four-stage, HEPA filter plenum at Rocky Flats in 1980 caused the first three stages of HEPA filters to blow out of their housing and the fourth stage to severely bow. Details of this recently declassified fire are presented in this paper. Although these previous findings suggest serious potential problems exist with the current water spray system in filter plenum , additional studies are required to confirm unequivocally that DOE`s critical facilities are at risk.
Synthesis of carbon encapsulated mono- and multi-iron nanoparticles

Core-shell nanostructures of carbon encapsulated iron nanoparticles (CEINPs) show unique properties and technological applications, because carbon shell provides extreme chemical stability and protects pure iron core against oxidation without impairing the possibility of functionalization of the carbon surface. Enhancing iron core magnetic properties and, in parallel, improving carbon shell sealing are the two major challenges in the synthesis of CEINPs. Here, we present the synthesis of both CEINPs and a new carbon encapsulated multi-iron nanoparticle by a new modified arc discharge reactor. The nanoparticle size, composition, and crystallinity and the magnetic properties have been studied. The morphological properties were observed by scanning electron microscopy and transmission electron microscopy. In order to evaluate carbon shell protection, the iron cores were characterized by selected area diffraction and fast Fourier transform techniques as well as by electron energy loss and energy dispersive X-ray spectroscopies. Afterward, the magnetic properties were investigated using a superconducting quantum interference device. As main results, spherical, oval, and multi-iron cores were controllably synthesized by this new modified arc discharge method. The carbon shell with high crystallinity exhibited sufficient protection against oxidation of pure iron cores. The presented results also provided new elements for understanding the growth mechanism of iron core and carbon shell.
Automatic Recognition and Counterfeit Detection of Ethiopian Paper Currency

Currency recognition is a technology used to identify currencies of various countries. The use of automatic methods of currency recognition has been increasing due its importance in many sectors such as vending machine, railway ticket counter, banking system, shopping mall, currency exchange service, etc. This paper describes the design of automatic recognition of Ethiopian currency. In this work, we propose hardware and software solutions which take images of an Ethiopian currency from a scanner and camera as an input. We combined characteristic features of currency and local feature descriptors to design a four level classifier. The design has a categorization component, which is responsible to denominate the currency notes into their respective denomination and verification component which is responsible to validate whether the currency is genuine or not. The system is tested using genuine Ethiopian currencies, counterfeit Ethiopian currencies and other countries’ currencies. The denomination accuracy for genuine Ethiopian currency, counterfeit currencies and other countries’ currencies is found to be 90.42%, 83.3% and 100% respectively. The verification accuracy of our system is 96.13%.
Effects of information culture and job satisfaction on the organizational innovation â€“ a study of different leadership styles as a moderatoritle

Organizational innovation plays a very important role in the process of Taiwan's economic miracle. In order to survive, the business organizations have to continually make drastic innovations in today's business environment. This study aimed to explore the impacts from information culture and employee satisfaction on the organizational innovation; as well as the interferences between leadership style and different cultures and employee satisfaction. A questionnaire survey was applied to domestic workers and semi-structured interviews to 5 field directors in technology, financial, manufacturing, service and other industries was also performed. Through descriptive statistics, factor analysis, regression analysis, single-variable variance analysis (ANOVA), our conclusions are: there is an impact on organizational innovation from information culture and job satisfaction; on the other hand, the compassion from different leadership style and institutional regulations play as moderating variables that interfere with the information cultural and job satisfaction. It eventually affects the organizational innovation.
Attitudes Toward Nosocomial Infections Associated Mortality at Intensive Care Units, and Evaluation of the Risk Factors

Background: Nosocomial infections (NIs) are an important public health problem worldwide, particularity in the intensive care units (ICUs). Objectives: The current study aimed to detect and highlight NIs as the critical factor in increasing mortality and morbidity to clarify the current health priorities and challenges in Iran. Patients and Methods: It was a retrospective study on 376 selected patients admitted in ICU at a public hospital in Tehran, Iran, from 2012 to 2014. The major studied NIs included: ventilator associated pneumonia (VAP), central venous catheter related primary bloodstream infections (CRBSIs or BSI), surgical site infections (SSIs) and catheter associated urinary tract infections (CAUTI or UTI). NIs were defined based on the centers for disease control and prevention (CDC) definitions. Site specific NIs rates, mortality rate and the length of hospital stay and other demographic or clinical variables were extracted. Results: Three hundred-four patients were examined for NIs. NIs ratewas19.7% andmortality rates were 44.4% and21.72% in infected and uninfected patients, respectively. The most frequent NIs was VAP and the highest observed rates of mortality were BSI in males (P = 0.050) and UTI in females (P = 0.05). The mortality rate in the infected patients was twice the other patients [2.187 (CI: %95: 1.154.13), P = 0.010]. The results showed that patients with cardiovascular respiratory dysfunction were exposed to higher risk of death. Infection rate increased in patients with diabetes and endocrine disease. Conclusions: To manage ICU patients, risk factors and causative procedures contributing to incidence and development of Nis should be considered. The most considerable points are accurate disinfection andmorestrict infection control procedure especially for prevent of VAP and BSI, which associated with the increasingof patient’s mortality. This issue is more crucial in the cases of the cardiovascular respiratory and diabetic patients.
“Should I really be here?” Exploring the relationship between Black men’s conceptions of wellbeing, subject positions and help-seeking behaviour

In the UK, Black men are over-represented at the coercive end of the mental health system but underrepresented in terms of seeking help voluntarily. This situation reflects longstanding inequalities that arise from multiple sources. Among these are the conceptions of well-being and help seeking that would enable Black men to access appropriate help at an early stage, and the ways in which mental health service providers could adapt practice to meet the needs of Black clients. The objectives of this study were to investigate the discourses that Black men draw upon in talking about themselves and their psychological wellbeing and in seeking help for psychological distress. Nine Black men were recruited via community centres in London, were interviewed, and the transcripts were analysed using Foucauldian discourse analysis. Four discourses were identified, namely oppression and discrimination, Black masculinity, communities and professional systems. These discourses demonstrate the ways in which Black men are discouraged from seeking help for psychological distress. The findings have implications for policy, service delivery, clinical practice and research.
Some Results on Measures of Interaction between Paired Risks

Co-risk measures and risk contribution measures have been introduced to evaluate the degree of interaction between paired risks in actuarial risk management. This paper attempts to study the ordering behavior of measures on interaction between paired risks. For various co-risk measures and risk contribution measures, we investigate how the marginal distributions and the dependence structure impact on the level of interaction between paired risks. Also, several numerical examples based on Monte Carlo simulation are presented to illustrate the main findings.
Efficient Partitioning of Large Databases without Query Statistics

An efficient way of improving the performance of a database management system is distributed processing. Distribution of data involves fragmentation or partitioning, replication, and allocation process. Previous research works provided partitioning based on empirical data about the type and frequency of the queries. These solutions are not suitable at the initial stage of a distributed database as query statistics are not available then. In this paper, I have presented a fragmentation technique, Matrix based Fragmentation (MMF), which can be applied at the initial stage as well as at later stages of distributed databases. Instead of using empirical data, I have developed a matrix, Modified Create, Read, Update and Delete (MCRUD), to partition a large database properly. Allocation of fragments is done simultaneously in my proposed technique. So using MMF, no additional complexity is added for allocating the fragments to the sites of a distributed database as fragmentation is synchronized with allocation. The performance of a DDBMS can be improved significantly by avoiding frequent remote access and high data transfer among the sites. Results show that proposed technique can solve the initial partitioning problem of large distributed databases.
Construct measurement in strategic management research: illusion or reality?

Strategic management research has been characterized as placing less emphasis on construct measurement than other management subfields. In this work, we document the state of the art of measurement in strategic management research, and discuss the implications for interpreting the results of research in this field. To assess the breadth of measurement issues in the discipline, we conducted a content analysis of empirical strategic management articles published in leading journals in the period of 1998–2000. We found that few studies discuss reliability and validity issues, and empirical research in the field commonly relies on single‐indicator measures. Additionally, studies rarely address the problems of attenuation due to measurement error. We close with a discussion of the implications for future research and for interpreting prior work in strategic management. Copyright © 2004 John Wiley & Sons, Ltd.
Benefit finding and well-being in children with life threatening illnesses: An integrative study

Objetivo. Examinamos en que medida la percepcion de beneficios o benefit finding (BF) en ninos con una enfermedad amenazante para la vida (como el cancer o el trasplante de organos) estaria relacionado con un rango de medidas positivas y negativas de funcionamiento psicologico asi como con algunas variables medicas. Metodo. Una muestra de ninos con una enfermedad amenazante para la vida (N=67, edad entre 7 y 18 anos) completaron la Escala de Percepcion de Beneficios para Ninos (Benefit Finding Scale for Children, BFSC) y otras medidas positivas y negativas de funcionamiento psicologico. Resultados. Los ninos expuestos a una enfermedad de gravedad moderada mostraron niveles mas altos de BF. BF se asocio positivamente a diferentes dimensiones de bienestar. Sin embargo, no se encontro relacion con medidas de malestar, a excepcion de algunos dominios de calidad de vida relacionados con la enfermedad. Conclusion. Estos resultados mostraron que el BF refleja un resultado positivo en si mismo y no una mera reduccion de malestar. A pesar de eso, deben considerarse algunos dominios de calidad de vida relacionados con la salud a la hora de realizar intervenciones terapeuticas para facilitar la percepcion de beneficios.