Miracle-dz/UniFAR-FTUs huggingface dataset:
Nifedipine-induced hypotension and myocardial ischemia in refractory angina pectoris.

Combined nitrate/beta-blocker/nifedipine therapy is commonly used to treat refractory angina pectoris. We have observed "paradoxical" myocardial ischemia in ten patients with refractory angina (seven receiving combined beta-blocker and nitrate therapy, and three receiving nitrate treatment alone) in whom nifedipine (mean dosage, 92 mg/day; range, 60 to 120 mg/day) induced a decrease in blood pressure, angina pectoris (10/10 patients), and ischemic ECG changes (7/10 patients). These ten patients, all of whom regularly reported angina within 20 to 30 minutes of nifedipine ingestion, were prospectively studied before and after usual nifedipine dose administration, while blood pressures, heart rate, and ECGs were recorded. Mean systolic BP fell from 109 to 94 mm Hg after nifedipine (P less than .001, paired t test); mean heart rate increased from 64 to 68 beats per minute (P less than .05); seven patients developed transient ECG changes (five with ST-T wave depression and two with ST-T wave elevation) during the hypotensive period. Nifedipine may provoke angina and myocardial ischemia in certain patients with refractory angina pectoris receiving concomitant beta-blocker and nitrate therapy.
Technology and Teacher–Student Interactions: A Review of Empirical Research

Abstract As technology becomes ubiquitous in education, it is critical to understand the ways in which technology influences interactions between teachers and their students. The overarching research question that guided this systematic review was: What does research tell us about how technology influences interactions between teachers and students in K–12 settings? This review examined studies published in peer-reviewed journals between 2005 and 2016. Findings indicated that studies examined two types of teacher–student interactions that technology influenced: (a) face-to-face interactions in traditional classrooms, and (b) online interactions in traditional and virtual classrooms. Technology promoted collaboration between teachers and students during learning activities, and teachers who used technology leveraged it to maximize their uses of strategies aimed at facilitating learning and promoting students' exploration of content. (Keywords: teacher–student interaction, educational technology, technology, integration)
Capturing health literacy assessment in the electronic health record through evidence-based concept creation: A review of the literature and recommendations for action

Health literacy is the capacity to understand and act upon health-related information and navigate the healthcare system. Published evidence demonstrates a relationship between health literacy and health status. Because of this, there are increasingly calls for a health literacy assessment to be collected and stored in the electronic health record for use by the healthcare team. This article describes the results of a literature review of health literacy assessment instruments with the goal of formulating semantically interoperable concepts that may be used to store the interpretation of the health literacy assessment in the electronic health record. The majority of health literacy instruments could be stored in the electronic health record using a three-concept solution of inadequate, marginal and adequate health literacy. This three-concept solution fully supports semantic interoperability needs across the patient care spectrum.
Solution processing of silver nanowires for transparent heaters and flexible electronics

We present the solution-based synthesis of silver nanowires (AgNWs) with an aspect ratio over 400 in a short growth time of 20 min. The addition of potassium chloride (KCl) during the growth regulates the supply of silver atoms and leads to an agglomerate-free and well-dispersed solution. Via a facile and scalable deposition technique, i.e. spray-coating, the AgNWs are deposited to transparent electrodes (TEs) on flexible or glass substrates. Without any post-treatment such as sintering that can harm the substrate, the films show a high transparency at a low sheet resistance. The TEs are characterized as transparent heaters in terms of their infrared, transient thermal and electrical properties up to a working temperature of 130 deg. C. For the use in flexible electronics, an AgNW-film on a polyvinyl chloride (PVC) substrate is tested under operation for 10,000 bending cycles and shows only a slight increase in resistance.
How knowledge sharing connects interpersonal trust and innovation capability

Purpose Knowledge sharing (KS) and innovation are generally believed as the antecedents of key outcomes that help firms to attain and sustain competitive advantage in long term. The purpose of this paper is to analyze the mechanism of how interpersonal trust and leader support affect KS and improve firm’s innovation capabilities. Design/methodology/approach This is a research paper which is built using empirical data collected from 68 manufacturing and service firms in China. Findings First, the findings show that leader supports moderate the correlation between interpersonal trust and KS. Second, KS serves as mediator in the relationship between interpersonal trust and firm’s innovation capabilities. Research limitations/implications KS plays a crucial role in stimulating innovation capabilities for both manufacturing and service firms. Future research should explore the effects of the motivational factors (such as positive psychological state, perceived benefits and costs) on KS and firm’s innovation capabilities. Practical implications The paper provides the evidence for the positive effects of interpersonal trust on KS, which in turn is significantly associated with product innovation and process innovation. It highlights the important role of leader supports in promoting the degree of sharing knowledge among individuals to enhance innovation capabilities for firms. Originality/value This study puts the theory of innovation forward based on exploring the key factors that have potential and positive impacts on two specific types of innovation capability, namely, product innovation and process innovation, for both manufacturing and service firms.
Active Region Design and Gain Characteristics of InP-Based Dilute Bismide Type-II Quantum Wells for Mid-IR Lasers

The electronic and optical properties of InP-based InGaAs/GaAsSbBi type-II quantum well (QW) structures are investigated theoretically. The detailed analyses of the InGaAs/GaAsSbBi type-II QW laser structures were based on a 14-band <inline-formula> <tex-math notation="LaTeX">$\text {k}\cdot \text {p}$ </tex-math></inline-formula> model. The theoretical results indicate that adding Bi into InGaAs/GaAsSb type-II active regions on InP allows wavelength extension, but with minimal impact to transition matrix element. Moreover, the gain characteristics of the active region of laser were studied as a function of the Bi composition. It is shown that these type-II QW structures are suitable for mid-infrared (2–<inline-formula> <tex-math notation="LaTeX">$4~{\mu }\text{m}$ </tex-math></inline-formula>) operation at room temperature.
Fetal Control of Calcium Transport across the Rat Placenta

ABSTRACT: Control of maternofetal calcium transfer across the in situ perfused rat placenta at day 21 of gestation (term 23 d) was investigated in both intact fetuses and those parathyroidectomized by decapitation on day 19. Decapitation resulted in significant fetal hypocalcemia. Injection of fetuses subcutaneously through the uterine wall with 0.43 μg bovine (b) PTH(l-84), 20 ng 1,25(OH)2D3 or 10 μL of the appropriate diluent resulted 2 h later in a raised fetal blood ionized Ca concentration only with bPTH(l-84) in both normal and decapitated fetuses. Fetal decapitation caused a significant (p < 0.001) fall in the clearance of 45Ca across the placenta (Kmf45Ca), which was significantly (p < 0.05) reversed after fetal bPTH(l-84) and 1,25 dihydroxy vitamin D3 (1,25(OH)2 D3) injection, but not back to normal levels. There was no effect of either hormone on Kmf45Ca in placentas from intact fetuses, or on Kmf51Cr-EDTA (used as an extracellular marker) in either group. When 4 ng/mL r[NIe8,21, Tyr34] PTH(l-34), 50 pg/mL 1,25(OH)2D3 or the appropriate diluent was perfused through placentas the only response observed was a significant (p < 0.05) increase in Kmf45Ca with 1,25(OH)2D3 perfusion in placentas from decapitated fetuses, Kmf51Cr-EDTA being unchanged. Finally, perfusion with 10-5M forskolin (an activator of adenylate cyclase) stimulated Kmf45Ca in placentas from both normal and decapitated fetuses. Although there was also some effect on Kmf51Cr-EDTA in the latter, there was none in the placentas from normal fetuses, and here the effect on Kmf45Ca was dose dependent with an initial response at 10-6 M. It is therefore suggested that fetal PTH and 1,25(OH)2D3 may play a permissive role in the control of maternofetal calcium transfer and that other hormones which act via cAMP may be involved in the acute regulation of calcium transfer under normal conditions.
Entrepreneurship, financial frictions and the welfare gains of business cycles

I propose a simple method to solve a heterogeneous agent model with entrepreneurship, financial frictions and aggregate uncertainty. Aggregate shocks, in this context, induce potential entrepreneurs to save in order to slack their financial constraints, leading to a significant increase in aggregate savings, pushing up wages and lowering interest rates. This channel can be strong enough to more than offset the effect of fluctuations on consumption, leading to welfare gains of business cycles.
Organo-mineral fertilisers from glass-matrix and organic biomasses: a new way to release nutrients. A novel approach to fertilisation based on plant demand.

BACKGROUND A glass-matrix fertiliser (GMF), a by-product from ceramic industries, releases nutrients only in the presence of complexing solutions, similar to those exuded by plant roots. This ensures a slow release of nutrients over time, limiting the risk of their loss in the environment. With the aim to improve fertiliser performance, GMF was mixed with vine vinasse (DVV), pastazzo (a by-product of the citrus processing industry, PAS) or green compost (COMP) and nutrient release was evaluated by citric and chloridric acid extraction, at different concentrations. RESULTS Theoretical and actual nutrients release were compared to evaluate possible synergistic effects due to the organic component added to the mineral fertiliser: phosphorus (+7.1%), K (+4.8%), Fe (+8.5%) and Zn (+5.5%) were released more efficiently by 2% citric acid from GMF + DVV, while Ca availability was increased (+5.3%) by 2% citric acid from GMF + PAS mixture. Both DVV and COMP increased by 12-18% the Fe release from GFM matrix. CONCLUSION Organic biomasses added to GMF increased the release of some macro and micronutrients through an 'activation effect', which suggests the employment of these organo-mineral fertilisers also in short-cycle crops production. Moreover, the re-use of some agro-industrial organic residues gives another 'adding value' to this novel organo-mineral fertilfertilisers.
An Examination of the Relative Abilities of Earnings and Cash Flows to Explain Returns and Market Values

We examine why, as a summary statistic, earnings is better than cash flows at explaining contemporaneous returns despite being a worse predictor of future operating cash flows. Several studies compare the ability of earnings and operating cash flows to predict valuation-related outcome variables including, stock returns, market values, and future operating cash flows. Although past results are mixed, recent studies suggest earnings are a better summary predictor of returns while operating cash flows better predict future operating cash flows. In this study, we replicate these two findings using a constant sample and consistent variable definitions, and examine several possible explanations for why earnings outperform cash flows in explaining contemporaneous returns and market values. Our results suggest that earnings outperform cash flows in explaining variation in both future free cash flows and discount rates. When directly comparing the two, we find that earnings' superior ability to explain variation in discount rates is more responsible than its ability to explain variation in future free cash flows. We provide evidence that the mechanism by which earnings explain more variation in discount rates than cash flows is accounting conservatism or timely loss recognition.
Is maternal transmission of coronary heart disease risk stronger than paternal transmission?

Objective: To test whether intergenerational transmission of coronary heart disease (CHD) to offspring is greater from the mother than from the father, the association between parental history of CHD and coronary mortality in male offspring was examined. Design: Prospective cohort study with 43 years of follow up. Setting: University of Glasgow. Participants: Male students (n = 8402) aged 16–30 years when examined in 1948 to 1968. Main outcome measure: Fatal CHD. Main results: Of the 8402 men studied, 615 (7.3%) reported a history of CHD in at least one of the parents: 479 (5.8%) for fathers only, 124 (1.6%) for mothers only, and a further 12 (0.2%) for both their parents. During follow up, 373 (4.4%) men died of CHD. Parental history of disease was associated with fatal CHD and controlling for personal risk factors such as cigarette smoking, body mass index, systolic blood pressure, and father’s social class did not attenuate this relation. The fully adjusted hazard ratios were 1.53 (95% confidence interval (CI) 1.08 to 2.18), 1.19 (95% CI 0.61 to 2.32), and 8.65 (95% CI 2.65 to 28.31) for father only, mother only, and both parents with CHD, respectively, compared with men whose parents did not have CHD. There was some evidence for interaction between parental histories (p = 0.049), with particularly high risk if both parents reported a history of CHD. Conclusions: This study found no differential transmission of CHD. Paternal history of CHD was at least as important as maternal history. Data from other comparable cohorts provide no consistent evidence of differential transmission. Intergenerational transmission of CHD does not appear to have differential effects between mothers and fathers.
Serum interleukin-6 and fever at diagnosis in children with acute leukemia.

PATIENTS AND METHODS We examined serum interleukin (IL)-6 and tumor necrosis factor (TNF) alpha levels at initial diagnosis in acute leukemic children in order to clarify the roles of these cytokines on the febrile and hematological responses in the disease. RESULTS IL-6 levels were significantly higher in 34 leukemic children than in 18 healthy controls and 15 patients with various malignant diseases in long remission (p < 0.0001). Three patients with apparent bacterial infections showed especially high IL-6 levels of > 100 pg/ml. In all the leukemic children, the high IL-6 levels at initial diagnosis had decreased to a low range at the time of complete remission, regardless of the use of antibiotics. In 10 of 14 leukemic children, TNF levels were high at diagnosis and then decreased to undetectable levels at remission. The relationship between IL-6/TNF levels and clinical/laboratory findings in leukemic children at diagnosis was also examined. Serum IL-6 significantly correlated with elevated body temperature (BT) (p < 0.001) and C-reactive protein (CRP) levels (p < 0.001), but not with other parameters such as leukocyte and platelet counts, hemoglobin levels, lactate dehydrogenase, and serum immunoglobulin. On the other hand, serum TNF did not show any statistical linkage with these parameters. CONCLUSION These data provide evidence for the role of IL-6 in the pathogenesis of tumor-related fever and other acute phase responses in acute leukemia.
The Effects of PspC on Complement-Mediated Immunity to Streptococcus pneumoniae Vary with Strain Background and Capsular Serotype

ABSTRACT Streptococcus pneumoniae may evade complement activity by binding of factor H (FH), a negative regulator of the alternative pathway, to the surface protein PspC. However, existing data on the effects of FH binding to PspC on complement activity are conflicting, and there is also considerable allelic variation in PspC structure between S. pneumoniae strains that may influence PspC-dependent effects on complement. We have investigated interactions with complement for several S. pneumoniae strains in which the gene encoding PspC has been deleted. The degree of FH binding varied between strains and was entirely dependent on PspC for seven strains. Data obtained with TIGR4 strains expressing different capsular serotypes suggest that FH binding is affected by capsular serotype. Results of immunoblot analysis for C3 degradation products and iC3b deposition assays suggested that FH bound to PspC retained functional activity, but loss of PspC had strikingly varied effects on C3b/iC3b deposition on S. pneumoniae, with large increases on serotype 4, 6A, 6B, and 9V strains but only small increases or even decreases on serotype 2, 3, 17, and 23F strains. Repeating C3b/iC3b assays with TIGR4 strains expressing different capsular serotypes suggested that differences in the effect of PspC on C3b/iC3b deposition were largely independent of capsular serotype and depend on strain background. However, data obtained from infection in complement-deficient mice demonstrated that differences between strains in the effects of PspC on complement surprisingly did not influence the development of septicemia.
L* Protein of the DA Strain of Theiler’s Murine Encephalomyelitis Virus Is Important for Virus Growth in a Murine Macrophage-Like Cell Line

ABSTRACT Strain GDVII and other members of the GDVII subgroup of Theiler’s murine encephalomyelitis virus (TMEV) are highly virulent and cause acute polioencephalomyelitis in mice. Neither viral persistence nor demyelination is demonstrated in the few surviving mice. On the other hand, strain DA and other members of the TO subgroup of TMEV are less virulent and establish a persistent infection in the spinal cord, which results in a demyelinating disease. We previously reported that GDVII does not actively replicate in a murine macrophage-like cell line, J774-1, whereas DA strain productively infects these cells (M. Obuchi, Y. Ohara, T. Takegami, T. Murayama, H. Takada, and H. Iizuka, J. Virol. 71:729–733, 1997). In the present study, we used recombinant viruses between these strains of the two subgroups to demonstrate that the DA L coding region of DA strain is important for virus growth in J774-1 cells. Additional experiments with a mutant virus indicate that L* protein, which is synthesized out of frame with the polyprotein from an additional alternative initiation codon in the L coding region of TO subgroup strains, is a key determinant responsible for the cell-type-specific restriction of virus growth. L* protein may play a critical role in the DA-induced restricted demyelinating infection by allowing growth in macrophages, a major site for virus persistence.
Debt, death, and divorce: aging into foreclosure in the U.S. Deep South

ABSTRACT Older homeowners have faced financial pressures since the Great Recession of 2007–2011, including from mortgages that are carried into retirement. In order to chart the postrecession impact of housing loss among older homeowners at a granular level, I used municipal and archival sources to analyze 484 households involving 784 foreclosees in a racially defined county of the U.S. Deep South. Three major and related findings emerged from this exploratory study. First, 65% of foreclosees had acquired second mortgages on their homes prior to the recession; an even higher percentage (77%) had incurred court judgments for auto loans, credit card debt, taxes, and medical expenses prior to foreclosure. Second, African-Americans experienced foreclosure at a significantly higher rate than Whites, especially among older women who were sole owners. Finally, 68% of foreclosees had either died or divorced within 5 years of foreclosure; these events represented financial stressors in older age, or mortgage debts for survivors and their families. The financial vulnerability of older foreclosees who carry mortgages into retirement has important implications for housing stability across the United States, particularly in communities of color and poor regions where housing loss is linked to age-income inequalities.
Glycoengineered Pichia produced anti-HER2 is comparable to trastuzumab in preclinical study

Mammalian cell culture systems are used predominantly for the production of therapeutic monoclonal antibody (mAb) products. A number of alternative platforms, such as Pichia engineered with a humanized N-linked glycosylation pathway, have recently been developed for the production of mAbs. The glycosylation profiles of mAbs produced in glycoengineered Pichia are similar to those of mAbs produced in mammalian systems. This report presents for the first time the comprehensive characterization of an anti-human epidermal growth factor receptor 2 (HER2) mAb produced in a glycoengineered Pichia, and a study comparing the anti-HER2 from Pichia, which had an amino acid sequence identical to trastuzumab, with trastuzumab. The comparative study covered a full spectrum of preclinical evaluation, including bioanalytical characterization, in vitro biological functions, in vivo anti-tumor efficacy and pharmacokinetics in both mice and non-human primates. Cell signaling and proliferation assays showed that anti-HER2 from Pichia had antagonist activities comparable to trastuzumab. However, Pichia–produced material showed a 5-fold increase in binding affinity to FcγIIIA and significantly enhanced antibody dependant cell-mediated cytotoxicity (ADCC) activity, presumably due to the lack of fucose on N-glycans. In a breast cancer xenograft mouse model, anti-HER2 was comparable to trastuzumab in tumor growth inhibition. Furthermore, comparable pharmacokinetic profiles were observed for anti-HER2 and trastuzumab in both mice and cynomolgus monkeys. We conclude that glycoengineered Pichia provides an alternative production platform for therapeutic mAbs and may be of particular interest for production of antibodies for which ADCC is part of the clinical mechanism of action.