Miracle-dz/UniFAR-FTUs huggingface dataset:
Life Cycle Costing in physical Asset Management: a multiple case study

Life Cycle Costing (LCC) is a powerful instrument in the Asset Management (AM) of physical systems. It is a valuable tool that can be used to support rational decision making and provide transparency and accountability about various operational, tactical and strategic AM decisions and their expected consequences. However, the application of LCC may not always be straightforward. In order to effectively use LCC in this context, it is important to further the understanding of the main challenges that practitioners face during the application of LCC in AM decision making. This publication summarizes the main descriptions and assumptions found in the literature on LCC into five postulates. These postulates are subsequently compared with empirical findings from four practical case studies within a Dutch utility provider on the use of LCC in AM decision making. Whereas some empirical findings agreed with the postulates, other findings were at least partially in disagreement, indicating inconsistencies between the theory of LCC and the practice of AM. The results suggest fundamental challenges in the use of LCC in AM, specifically regarding the objectives of using LCC and the scope of what is included in the assessment. Practitioners can use this article to avoid the pitfalls of using LCC in the context of AM and researchers can use the findings to guide further work on developing methods and tools that support AM.
The contingency-shifting variant Iowa Gambling Task: An investigation with young adults

The contingency-shifting variant Iowa Gambling Task (IGT), in which the reward and punishment contingencies of different decks of cards are systematically altered, was investigated with a large group of healthy young adults (n = 208). Our findings demonstrate that the onset of unsignaled, contingency-shift phases initially disrupted learning but that performance subsequently improved during each shift. Subjective experience ratings were positively correlated with performance across all phases. A regression model showed that performance early in the task, in Blocks 3 and 4, significantly predicted later ability to shift to the changing contingencies. Subdividing participants into high performer and low performer groups revealed an increased number of selections of previously good-now-bad decks in the latter group. Overall, the contingency-shifting variant IGT may have potential as a novel measure of reversal learning in experimental and clinical settings.
Osteogenic Capacities of Tibial and Cranial Periosteum: A Biochemical and Histologic Study

The periosteum has an important role in bone regeneration. The purpose of this study was to evaluate and compare the osteogenic capacities of tibial and cranial periosteum. To achieve this, 44 New Zealand male rabbits were divided into two groups, each consisting of 22 rabbits. In group 1, periosteal flaps were prepared on the tibia of the posterior cruris of each side. In group 2, bilateral periosteal flaps were prepared on the cranial region. New bone formation was estimated quantitatively by measuring the alkaline phosphatase and osteocalcin levels, because they are the indicators of osteoblastic activity. At weeks 1, 2, 4, and 8, biopsies were taken from five animals of each group for biochemical analyses, and at weeks 2 and 8, biopsies were taken for histologic evaluation. Higher alkaline phosphatase and osteocalcin levels were evaluated in group 1, and more bone formation was observed in group 1. The results showed that osteogenic capacity is higher in tibial periosteum than cranial periosteum.
Repeated oral vitamin K prophylaxis in West Germany: acceptance and efficacy

Owing to concern that neonatal vitamin K prophylaxis might cause childhood cancer,1 parenteral vitamin K prophylaxis for all newborn infants has been abandoned in the United Kingdom2 and Germany.3 In its place three oral doses of vitamin K (0.5 mg in the United Kingdom, 1 mg in Germany) are now recommended for healthy neonates (at birth and during days 4-10 and weeks 4-6). We investigated whether these recommendations are being followed and whether three oral doses of vitamin K are as effective as parenteral vitamin K for preventing late haemorrhagic disease of the newborn. We drew a random sample of 100 obstetric units from all 995 such units in West Germany. In August 1993 we sent questionnaires to the consultants in charge of these 100 units asking about their use of vitamin K prophylaxis. Surveillance for late haemorrhagic disease was carried out by …
The Impact of Working Relationships in the Accounting and Audit Cycle

This study evaluates literature on the wheel of audit partners in Chinese companies and institutions by examining the impact of relationships before and after the rotation between the input and output partners. We consider the partners in the rotation before the rotation, before the work relationship. We find two different results from the previous working relationships: (a) increasing the likelihood of the outgoing partners after the cooling period, and (b) reducing the quality of the audit and lower accounting after the rotation. These findings ask whether the rotational partners are truly independent of the working relationships.
Demonstration of osteocytic perilacunar/canalicular remodeling in mice during lactation

Osteoclasts are thought to be solely responsible for the removal of bone matrix. However, we show here that osteocytes can also remove bone matrix by reversibly remodeling their perilacunar/canalicular matrix during the reproductive cycle. In contrast, no osteocytic remodeling was observed with experimental unloading despite similar degrees of bone loss. Gene array analysis of osteocytes from lactating animals revealed an elevation of genes known to be utilized by osteoclasts to remove bone, including tartrate‐resistant acid phosphatase (TRAP) and cathepsin K, that returned to virgin levels upon weaning. Infusion of parathyroid hormone–related peptide (PTHrP), known to be elevated during lactation, induced TRAP activity and cathepsin K expression in osteocytes concurrent with osteocytic remodeling. Conversely, animals lacking the parathyroid hormone type 1 receptor (PTHR1) in osteocytes failed to express TRAP or cathepsin K or to remodel their osteocyte perilacunar matrix during lactation. These studies show that osteocytes remove mineralized matrix through molecular mechanisms similar to those utilized by osteoclasts. © 2012 American Society for Bone and Mineral Research.
The effect of commodity price changes and USD/IDR exchange rate on Indonesian mining companies’ stock return

There are many variables that will be influencing stock return. Some of those variables are come from the commodity market, such as gold, price and crude oil price changes, and also come from the exchange rate market. This study is about to test the effect of changes prices of gold, silver, crude oil, and exchange rate to the stock return of mining sector companies in Indonesia. There are 48 companies engaged in the mining sector listed on the Indonesia Stock Exchange (IDX). From 48 companies this study uses the purposive sampling method to choose a sample within the criteria, and there are 13 selected companies that will be the object of this study. This study also used an analysis tool GARCH (1,1) to avoid abnormal data. Before advancing to GARCH (1,1) analysis, the data must be tested the stationary first by using the Augmented Dickey-Fuller Test (ADF) to make sure the data stationary or not by using level, 1st difference, and two difference. The result shows that gold has a significant positive effect on stock return mining sector companies such as INCO, KKGI, PTBA, and TINS. Silver has a significant positive effect on HRUM companies and negatively on RUIS. Crude oil has a significant positive effect on HRUM and PTBA firms. Exchange rates have a significant negative impact on companies. ANTM, CTTH, DOID, ELSA, HRUM, ITMG, and KKGI. JEL Classification : E03, F31, G11, G23 DOI : https://doi.org/10.26905/jkdp.v23i1. 2084
Exploring New Strategies for Facial Recall

Marked discrepancies exist between levels of face recognition and accuracy of face recall registered by Photofit. One of the reasons for this may be that Photofit demands that subjects initially identify features in isolation and such a strategy is incompatible with normal coding processes. Experiment 1 compared the normal feature-based approach to face building with a condition which permitted subjects to work from an established face (‘Mr Average’). No superiority for the latter condition could be established. Experiment 2 contrasted the standard building method with one in which subjects were offered a variety of facial types as potential starting points. Again, accuracy was no higher under the novel procedure. It was concluded that there were no grounds advocating for a wholesale change in current tactics of Photofit building which emphasize feature-selection prior to amending a total facial composite.
Breath Amplitude Modulation of Heart Rate Variability in Normal Full Term Neonates

ABSTRACT. The relationship between heart rate variability and respiration patterns was investigated using spectral analysis techniques in nine full-term infants whose ages ranged from 39-75 h. All the infants were studied during sleep, although no attempt was made to classify rapid eye movement or nonrapid eye movement states prospectively. The data obtained were examined to determine which aspects of neonatal breathing patterns are correlated with heart rate variability. Three spectral regions of heart rate variability could be identified: a very low frequency region below 0.02 Hz; a low frequency region from 0.02-0.20 Hz; and a high frequency region above 0.20 Hz. The dominant heart rate variability activity in these neonates was seen in the very low and low frequency regions, with little activity in the high frequency regions. In contrast to older infants and adults, respiration and heart rate variability were not strongly related through a high frequency region respiratory sinus arrhythmia but rather through a breath amplitude sinus arrhythmia which occurs in the low frequency region of the spectrum. The prominent very low frequency activity and the low frequency activity ascribed to breath amplitude modulation may result from autonomic nervous system mediation of chemoregulation.
Pulsed-waveform oscillators with short nonlinear transmission lines

Soliton oscillators enable the generation of short-time pulses, applicable in sampling of fast signals or as probe signals in radar systems. In this paper, the analysis and design of soliton oscillators and frequency dividers, based on nonlinear transmission lines (NLTL) is presented. Different configurations are compared, considering ease of implementation, stability aspects and efficiency. A method is proposed to reduce the number of NLTL inductance-diode stages, using reflection effects together with a proper selection of the line elements, ensuring a quick evolution of the waveform across the NLTL cells. Special attention is paid to the phase-noise analysis, evaluating the impact of different noise sources with the aid of phase-sensitivity functions. Synchronized behaviour, enabling frequency multiplication of high order, and frequency division due to parametric effects are analyzed.
PARP inhibitors: will the new class of drugs match the hype?

BRCA proteins play a role in DNA repair. Healthy cells have several different DNA repair pathways at their disposal; PARP is required for the base excision repair pathway, which mends single-strand nicks, whereas the BRCA proteins are critical for the homologous recombination pathway, which fi xes double-strand breaks. Cells can survive when one repair system breaks down, but they start to die when two of the DNA repair mechanisms stop functioning. Therefore, the combination of a PARP inhibitor and loss of a functional BRCA protein leads to cell death. Preclinical data suggested that the hypothesis was correct; tumor cells that lacked functional BRCA1 or -2 died in the presence of PARP inhibition in vitro. Researchers found that cells that had one normal BRCA allele and one mutant BRCA allele — which is typical of most cells in an individual who carries a BRCA1 or -2 mutation — tolerate PARP inhibition without a problem. In the tumor cells, however, which have lost their remaining functional BRCA gene, PARP inhibition is toxic.
[Comparative study on content of chlorogenic acid in Lonicera japonica and L. macranthoides].

OBJECTIVE To exploit and utilize reasonably the abundant natural resources by appraising the medicinal purposes of Lonicera macranthoides Hands-Mazz. through the content of the useful chemical constitutents chlorogenic acid. METHOD The content of chlorogenic acid in the flowers of L. macranthoides Hands-Mazz in Human and L. japonica Thunb. in Henan and Shandong was compared by HPLC. RESULT The contents of chlorogenic acid were 4.00% and 4.52% in L. macrathoides from Longhui and Xinning County of Hunan respectively. The contents were 2.20% and 2.46% in L. japonica from Shangdong and Henan respectively. CONCLUSION The content of chlorogenic acid in L. macranthoides was higher than that in Lonicera japonica.
Horizontal Diffusion Elutriation: A New Size-Separation Technique for Preparation of Rodent-Respirable Fibers for Animal Testing

Short-and long-term animal experiments are used to examine the toxicology and biopersistence of various types of fibers. In order to ensure an adequate exposure dose for testing, modern experimental protocols specify that the exposure aerosol (in an inhalation test) or the fibers (in an intratracheal instillation [IT] test) must contain at least a minimum concentration of long (> 20 μm) rodent-respirable fibers. As produced and handled, most fibers contain a distribution of diameters and lengths, only some of which are both long and rodent-respirable. Therefore, it is necessary to size-separate the fibers to enrich the proportion of long, rodent-respirable fibers in the material to be tested. This article presents a new and relatively simple method for size separation that avoids some of the difficulties associated with other methods. The method, termed horizontal diffusion elutriation (HDE), is illustrated by size-separating refractory ceramic fiber (RCF) and four polycrystalline alumina (PCA) fibers.
A case of xanthoma disseminatum treated with imatinib mesylate

Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India Correspondence Sunil Dogra, Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh 160012, India. Email: sundogra@hotmail.com Funding information None
The Presence and Characteristics of Female Directors: How They Influence Firm Performance

This research aims to assess the effects of female directors’ presence and characteristics on firm profitability, measured with Return on Assets. Observed characteristics include education, age, and foreign nationality. 364 publicly-traded non-financial Indonesian corporations were observed from 2013 to 2016 (n=1,456). Our fixed effects panel regression analysis finds that the presence of female directors on the board positively influences profitability: women bring in a productive dynamic that complements the style of the male-dominated board. Meanwhile, none of the other independent variables significantly affect ROA, signifying that our results do not correspond with Upper Echelons theory. We also recommend corporations to appoint female board members based on merits and not just for the sake of diversity, as they may improve firm performance. Keywords: female directors, firm performance, profitability, upper echelons, corporate governance
Assessment of Perceived Ease of Use and Instructional Use of ICT by Lecturers in Technical Training Institutions in Kenya

In the past ten years, Information Communication Technology (ICT) has become an essential part of our learning and development in education. The rapid development of these new technologies coupled with the worldwide challenge to educate all children has led to a global reform and development of teacher education and motivated educational Institutions to redesign and restructure their teaching methods to enable students equip themselves for the future. The main purpose of this study therefore was to explore the relationship between Perceived Ease of Use and instructional use of ICT by Lecturers in Technical Training Institutions in Kenya. The study adopted the quantitative research design. A sample size of 629 respondents was drawn from a total population of 2909 Lecturers in Technical Training Institutions in Kenya. Data were collected using questionnaires. The quantitative data obtained from the administrated questionnaires were analyzed using descriptive statistics. The findings indicated that use of ICT by lecturers’ is perceived to greatly improve instruction. The study recommends that lecturers be encouraged to use ICT for instructional purposes because it greatly improves the passage of instruction.
Forces of various nickel titanium closed coil springs.

OBJECTIVE To compare the forces generated by 14 different 9 mm springs supplied by five different companies. MATERIALS AND METHODS Five replicates of 14 different 9 mm springs were evaluated, resulting in 70 total specimens. Each was extended once from its resting length to 12 mm and then was deactivated. All tests were performed in a 37 degrees C water bath. Forces were recorded at the 12 mm extension and deactivation distances of 9 mm, 6 mm, 3 mm, and 1 mm using an MTS force gauge. Data were collected with Testworks software, version 4.0, and were analyzed by analysis of variance (ANOVA) with one factor alternated. RESULTS Mean peak load forces at 12 mm were significantly different between springs, and these forces varied from 147 to 474 grams. Mean unload forces measured at 9 mm, 6 mm, and 3 mm of deactivation values were highly variable, and only 6 of the 14 springs exhibited a "physiologic" mean unload force of 50 grams or less over the total deactivation range. CONCLUSIONS Few springs tested exhibited physiologic peak load forces and constant deactivation forces. This study suggests that labeling of nickel titanium closed coil springs is confusing and misleading.
The customer in focus Patient roles in designing and improving care processes

Challenges in today’s healthcare are many. One of them is that a patient focus is missing in design and improvement of care processes. Traditionally healthcare professionals have done the improvements of care processes in a way they assumed were best based on their experiences and professional knowledge. However, it is only the patient that has experiences of the entire care process. Hence, this way of improving care can contribute to building barriers between specialist functions, for instance between different outpatient clinics and hospital wards. Since the late 1980s, principles, practices and tools for quality management have received increased attention from healthcare organizations. Process orientation with a patient focus has been spread as an example of a beneficial quality management practice. Patient experiences are becoming important sources of information, and there are recent examples of collaboration between patients and healthcare professionals in the actual improvement of care processes. The purpose of this thesis is to contribute to the knowledge base concerning design of good care. More specifically, it aims to explore patient’s roles in care processes, and the ways in which a patient focus can contribute to the design and improvement of care processes. The thesis is based on three improvement projects in care processes. The three improvement projects are described in three appended papers. Paper I is about design of a medication process with a Design for Six Sigma (DFSS) approach. Paper II studies an application of the Kano model aimed to support development of an understanding of patients as customers in various roles in children’s and women’s healthcare. Finally, Paper III is based on a project in a neonatal process, using experience-based co-design – EBCD. The thesis is based on an action research approach at Skaraborg hospital, Sweden. One common notion in the appended papers is that there is a need for customer orientation in healthcare related to care processes, instead of focus on different functions. Moreover, in care processes the patient is a customer pursuing various roles. When improving care processes, experiences of both patients and healthcare professionals is needed. However, in each case considerations has to be made about the importance of involving patients in improvement work. The result of the studies also highlights various roles that patients can have in improvement of care processes, including the role for the patient as co-designer of improvements. Still, the co-designer role asks for a new way of viewing patients in healthcare. A view based on more equal power between patients and healthcare professionals. Thus could be viewed as a paradigm shift in healthcare. Keywords: quality management, customer focus, care processes, patient roles, healthcare
Large animal models of genetic disease: pertinent IACUC issues.

The editors of this issue have assembled an exemplary group of expert reviews that provide an effective overview of the current use of large animal models in genetic disease research and describe the importance of these models in bringing new, safe, and effi cacious treatments to clinical practice. In this essay we focus on both practical and technical considerations for the conduct of this type of research from the standpoint of those who prepare and review institutional animal care and use committee (IACUC) protocols. We discuss the history of these types of research subjects and practical considerations for the use of these models. As IACUC membership often varies in expertise, we spend some time on issues that may seem obvious to the expert but that may not be readily apparent to nonscientist IACUC members. Many of our observations are based on our own and our colleagues’ experiences in the preparation and review of protocols, refl ecting common questions or themes raised during the review process. We do not address issues relevant to individual species but rather the general considerations, including the advantages and constraints, of maintaining and using these large animal models for the study of genetic disease.