Miracle-dz/UniFAR-FTUs huggingface dataset:
Radiotherapy versus Radiotherapy plus Chemotherapy in Stages I and II Hodgkin's Disease.

In a multi-centre study in which data from all Danish Hodgkin patients have been registered since 1971, all patients in supradiaphragmatic stages I or II, as confirmed by staging laparotomy, were randomized to either radiotherapy (RT) to supra- and infradiaphragmatic lymph node regions (total nodal irradiation, TNI), or RT to a mantle field followed by 6 cycles of MOPP combination chemotherapy (RT+ CT). Interim results up to July 1979, when 237 patients had entered the study, showed a treatment failure rate of 19/117 in the TNI group and 4/120 in the RT+CT group (P < 0.05). 19 of the 23 relapsing patients were under the age of 40, and 14 in the TNI group and 3 in the RT+CT group belonged to stage II. 13 patients had nodular sclerosis, 9 had mixed cellularity and 1 had lymphocytic predominance histology. 12 of the 19 relapsing patients in the TNI group had hilar or mediastinal involvement as against 51 of the 117 patients in the entire group. Most of the TNI failures could be retreated, and as yet there is no difference in the overall survival.
The Effects of Trial Repetition and Individual Characteristics on Decision Making Under Uncertainty

The authors examined participants' preferences between certain and uncertain outcomes in a multistage gambling task and the effects of individual difference characteristics on those preferences. In Study 1, 144 participants made choices in single-stage gambles under gain and loss conditions and replicated the certainty effect in a previous study (D. Kahneman & A. Tversky, 1979). In Study 2, 94 participants engaged in a multistage gambling task using the same decision problems as those in Study 1. They also answered a questionnaire consisting of the Japanese version (M. Kamahara, K. Higuchi, & N. Shimizu, 2001) of the Locus of Control Scale (J. B. Rotter, 1966), the Reflection-Impulsivity Scale (K. Takigiku & A. Sakamoto, 2001), and a Japanese version (M. Terasaki, K. Shiomi, Y. Kishimoto, & K. Hiraoka, 1987) of the Sensation-Seeking Scale (M. Zuckerman, 1994). The results indicated that the certainty effect (Kahneman & Tversky) disappears in multistage gambling tasks and that differences in reflection-impulsivity and in gender influence the process of decision making under gain conditions. These results are discussed in terms of the decision strategies and cognitive biases involved in the multistage gambling task.
Comparative study between the internal behavior of GA and PSO through problem-specific distance functions

The evolutionary approach is a family of probabilistic search algorithms. The genetic algorithm (GA) and particle swarm optimization (PSO) are members of the evolutionary family, where both GA and PSO have been proven to be successful in finding good solutions in a short time for many combinatorial problems. In this paper, we have proposed several metrics, in the form of distance functions (DP), to examine and compare the internal behavior of GA and PSO based on a problem-specific DF rather than an algorithmic DF. Our initial experimental results show that PSO has more smooth and steady distance function values than GA.
Injuries to the Head and Face in Women's Collegiate Field Hockey

Objective:To investigate the incidence and severity of head and facial injuries in female collegiate field hockey players. Design:Prospective, survey-based study. Setting and Participants:Certified athletic trainers and athletes at 6 Division I institutions. Interventions/Assessment of Risk Factors:Head and facial injuries were documented during practices and games during 2 women's field hockey seasons. Main Outcome Measurements:The total number of incidents that resulted in a head or facial injury, the total number of head and facial injuries, the injury type, location, and source, and the amount of time the injured athlete lost from play. When the injury occurred, either in a game or practice, was documented in year 2. Results:A total of 253 student-athlete seasons (each season that a player competed was considered 1 student-athlete season) were completed. A total of 57 incidents occurred with 62 head and facial injuries reported (5 incidents yielded 2 injuries each). Most injuries were due to contact with the ball (56%); the majority of injuries were lacerations (32%). A relatively high number of facial fractures were reported (13%). Sixty-five percent of the injuries resulted in less than 1-day time loss and would not have been reportable in many traditional injury surveillance systems. Conclusions:The high number and rate of serious or potentially serious injuries occurring to the head and face in female collegiate field hockey players is a concern. Prevention measures, including better protective equipment for the head and face, may help reduce future head and facial injuries in these athletes.
Interleukin-4 Receptor Alpha-Deficient BALB/c Mice Show an Unimpaired T Helper 2 Polarization in Response to Leishmania major Infection

ABSTRACT We recently generated interleukin-4 (IL-4) receptor alpha-deficient (IL-4Rα−/−) BALB/c mice and showed evidence for a protective role of IL-13-mediated functions in leishmaniasis. In this study, we investigated the IL-4 expression and T helper 2 (Th2) development in Leishmania major-infected IL-4Rα−/− mice. Here we show that the early burst of IL-4 expression observed in L. major-infected BALB/c mice is independent of IL-4Rα-mediated functions. Subsequently, we confirmed an impaired Th2 development in vitro. Unexpectedly, duringL. major infection, isolated CD4+IL-4Rα−/− T cells expressed high IL-4- but low gamma interferon (IFN-γ)-specific mRNA, comparable to Th2-polarized BALB/c CD4+ cells and in contrast to Th1-polarized C57BL/6 CD4+ cells. Since antigen-specific restimulated popliteal lymph node cells (PLN) of IL-4Rα−/− mice also responded with high IL-4 but low IFN-γ production, comparable to Th2-polarized cells from wild-type BALB/c mice and in contrast to Th1-polarized C57BL/6 cells, these results suggested an unimpaired Th2 polarization during an established infection with L. major. To further define the observed IL-4 receptor-independent Th2 cell phenotype, we determined an independent Th2 marker, the IL-12 receptor beta-2 (IL-12Rβ2)-specific transcript levels of CD4+ T cells. Confirming Th2 polarization in L. major-infected IL-4Rα−/− mice, comparable IL-12Rβ2 message levels between CD4+ T cells from infected IL-4Rα−/− mice and Th2 cells from BALB/c mice were found, whereas Th1-polarized C57BL/6 cells showed strikingly increased IL-12Rβ2 expression levels. These results indicate that signals mediated by the IL-4Rα are not necessary to induce and sustain an efficient IL-4 expression and Th2 polarization in L. major-infected BALB/c mice and suggest that IL-4Rα-independent mechanisms underlie the default Th2 development in L. major-infected BALB/c mice.
Beyond Appearances: The Risk-Reducing Effects of Responsible Investment Practices

This article examines the theoretical motivations underlying the conflicting beliefs in support of and against responsible investment (RI) and presents unique quantitative evidence to illustrate how such conflicting logics produce a curvilinear (inverted U-shape) relationship between screening intensity and two measures of risk. First, I argue that, whereas limiting the investable universe by using RI screening criteria increases the risk specific to the portfolio, very high screening intensity can reduce this risk. This is due to the fact that information benefits enable fund managers to be more selective, allowing them to select less risky firms. Second, by drawing on behavioral studies, I argue that this same curvilinear relationship occurs when examining the flow of money coming in and out of a fund. That is, high RI screening makes ethical investors “stickier” and less likely to pull money out of a fund because they are attracted to its ethical properties. I test my hypotheses using a data set of all known European RI screening equity mutual funds. I generally find strong support for both hypotheses. This has an important implication for investors: For high screening intensity and meaningful RI practices, RI is associated with a significant risk reduction.
Long-term follow-up of patients with acute liver failure of indeterminate aetiology

Objective. To determine the clinical characteristics of patients with acute liver failure of indeterminate cause and their long-term outcome in comparison with patients with acute liver failure of obvious aetiology (acetaminophen and mushroom poisoning, Budd-Chiari syndrome, acute viral hepatitis) and other controls (idiosyncratic drug reactions, autoimmune hepatitis and Wilson's disease). Material and methods. All patients with acute liver failure and listed for liver transplantation in Sweden between 1984 and 2006 were included in a retrospective analysis. Results. A total of 71 patients with acute liver failure were identified, 33 with indeterminate cause (IDC group), 23 with obvious aetiology (OE group) and 15 other controls (OC group). Before admission to the transplant centre, IDC patients were hospitalized in the referring hospital for 9 days (4–15) versus 1.5 days (1–3) in the OE group (p<0.001) and 7 days (2–14) in the OC group (NS). Serum bilirubin was higher (p<0.001), whereas peak creatinine was lower (p=0.001) in the IDC group compared with the OE group but was not significantly different from the OC group. There were no significant differences in 1-, 3-, 5- and 10-year patient and graft survival rates between the IDC group and the OE or the OC group. Conclusions. Patients with acute liver failure of indeterminate cause seem to differ from those with obvious aetiology in clinical and biochemical presentation but are similar to other controls. The overall long-term outcome seems to be similar in patients with an unknown aetiology as in those with a specific aetiology.
The Nek6 and Nek7 Protein Kinases Are Required for Robust Mitotic Spindle Formation and Cytokinesis

ABSTRACT Nek6 and Nek7 are members of the NIMA-related serine/threonine kinase family. Previous work showed that they contribute to mitotic progression downstream of another NIMA-related kinase, Nek9, although the roles of these different kinases remain to be defined. Here, we carried out a comprehensive analysis of the regulation and function of Nek6 and Nek7 in human cells. By generating specific antibodies, we show that both Nek6 and Nek7 are activated in mitosis and that interfering with their activity by either depletion or expression of reduced-activity mutants leads to mitotic arrest and apoptosis. Interestingly, while completely inactive mutants and small interfering RNA-mediated depletion delay cells at metaphase with fragile mitotic spindles, hypomorphic mutants or RNA interference treatment combined with a spindle assembly checkpoint inhibitor delays cells at cytokinesis. Importantly, depletion of either Nek6 or Nek7 leads to defective mitotic progression, indicating that although highly similar, they are not redundant. Indeed, while both kinases localize to spindle poles, only Nek6 obviously localizes to spindle microtubules in metaphase and anaphase and to the midbody during cytokinesis. Together, these data lead us to propose that Nek6 and Nek7 play independent roles not only in robust mitotic spindle formation but also potentially in cytokinesis.
Density patterns in metal films produced by laser interference

Fringed periodic patterns have been produced by laser interference at 193 nm in an almost continuous 9.5 nm-thick Ag film that exhibits a number density of ≈189 μm−2 holes. Patterns with four periods in the range of 1.8–10.2 μm were produced by changing the projection optics. At high fluences, the film breaks up into nanostructures around the regions exposed to intensity maxima due to laser-induced melting. At low fluences, a new process is observed that is triggered at the initial holes of the film by solid-state dewetting. Once the fluence is high enough to prevent the temperature balance across the pattern, mass transport from cold to hot regions is observed, leading to film densification in regions around intensity maxima sites. The novel patterns are thus formed by fringes of material that is more/less dense than the as-grown film, each of which is located at intensity maxima/minima sites, and have negligible topography. Comparing the present results to earlier reports in the literature shows that the thermal gradient across the pattern is influenced by the initial film microstructure, rather than by the thickness. The existence of a minimum period, which is achievable depending on the thermal continuity of the film, is also discussed.
Influence of surface roughness on the color of dental-resin composites

This study deals with the influence of surface roughness on the color of resin composites. Ten resin composites (microfilled, hybrid, and microhybrid) were each polished with 500-grit, 1 200-grit, 2 000-grit, and 4 000-grit SiC papers. The roughness parameter (Ra) was measured using a Plμ confocal microscope, and field-emission scanning electron microscope (Fe-SEM) images were used to investigate filler morphology. Color was measured using a spectroradiometer and a D65 standard illuminant (geometry diffuse/0° specular component excluded (SCE) mode). Surface roughness decreased with grit number and was not influenced by filler size or size distribution. A significant influence of Ra on lightness (L*) was found. Lightness increased with decreases in roughness, except for specimens that underwent polishing procedure 4 (PP4; 500-grit, 1 200-grit, 2 000-grit, and 4 000-grit SiC papers consecutively). Generally, it was found that surface roughness influenced the color of resin composites. The composites that underwent PP1 (500-grit SiC paper) exhibited significant differences in chroma (C*), hue (h°), and lightness (L*) compared to composites that underwent PP3 (500-grit, 1 200-grit, and 2 000-grit SiC papers consecutively) and PP4. Color difference (ΔE*) between the polishing procedures was within acceptability thresholds in dentistry.
Monte Carlo modeling of threshold variation due to dopant fluctuations

This paper presents a new 3D Monte Carlo approach for modeling random dopant fluctuation effects in MOSFETs. The method takes every silicon atom in the device into account and is generally applicable to arbitrary nonuniform doping profiles. In addition to body dopant fluctuations, the effect of source-drain dopant fluctuations on short-channel threshold voltage is studied for the first time. The result clearly indicates the benefit of retrograde body doping and shallow/abrupt source-drain junctions. It also quantifies the magnitude of threshold voltage variations due to discrete dopant fluctuations in an optimally designed 25 nm MOSFET.
Kinetics of CD4+ and CD8+ Memory T-Cell Responses during Hepatitis C Virus Rechallenge of Previously Recovered Chimpanzees

ABSTRACT The immunological correlates of hepatitis C virus (HCV)-specific immunity are not well understood. Antibodies to HCV structural proteins do not appear to play a key role in clearance of the virus and do not persist after recovery. Here, we studied the kinetics of the cellular immune responses of three HCV-recovered chimpanzees during rechallenge with increasing doses of homologous HCV. Although HCV envelope antibodies remained undetectable throughout the rechallenge, all animals mounted rapid HCV-specific T-cell responses. The pattern of the cellular immune response in blood and liver correlated with the virological outcome. The animal that most rapidly cleared circulating HCV as determined by nested reverse transcription-PCR (RT-PCR) displayed the most vigorous and sustained response of gamma interferon (IFN-γ)-producing and proliferating CD4+ T cells in the blood. Vigorous CD4+ T-cell proliferation during viremia was followed by an increased frequency and a phenotypic and functional change of the tetramer+ CD8+ T-cell population. The second animal cleared HCV initially with strong peripheral and intrahepatic CD4+ T-cell responses but experienced low-level HCV recrudescence 12 weeks later, when HCV-specific T cells became undetectable. The third animal maintained minute amounts of circulating HCV, detectable only by nested RT-PCR, in the face of a weak IFN-γ+ T-cell response. Collectively, the results suggest protective rather than sterilizing immunity after recovery from hepatitis C. The rate of HCV clearance following reexposure depends on the cellular immune response, the quality and quantity of which may vary among chimpanzees that recovered from HCV infection.
Movement and containment of microbial contamination in the nutrient mist bioreactor

SummaryIn vitro plant cultures tend to get contaminated easily with bacteria and fungi because they are grown for long times in sugar-rich media. Contamination of bioreactors is particularly problematic as larger volumes entail larger losses. To study the movement and develop subsequent control of contaminants in the mist bioreactor, the spore-forming microbes Penicillium chrysogenum and Bacillus subtilis were deliberately inoculated into three possible locations in the reactor: the growth chamber (GC), the medium reservoir (R), or the mist-generating chamber (MG). Compared to inoculation into either R or MG regions, the growth of P. chrysogenum inoculated into the GC required 3 more days (c. 60% more time) to move throughout the rest of the reactor. In contrast, regardless of where B. subtilis was inoculated (GC, R, or MG), it took 7d to contaminate the entire system. The movement of filamentous fungi and bacteria seems to follow the same route of contamination throughout this reactor. Once visibly present in the reactor, neither contaminant was controllable by addition of the biocide, Plant Preservative Mixture (PPM). Both microbes were completely inhibited if PPM was added to the MG at the time of inoculation and then again 2-d post-inoculation of plants. Reactors were fun for 3 wk. Plants remained free of contamination. These results will prove useful in the implementation of large-scale in vitro culture systems.
Prevalence and risk factors of cervicovaginal HIV shedding among HIV-1 and HIV-2 infected women in Dakar, Senegal

Objectives: To assess the risk determinants and prevalence of cervicovaginal shedding of HIV-1 and HIV-2 among women in Dakar, Senegal. Methods: We conducted a cross sectional study of 153 HIV seropositive female sex workers (FSW) and another 142 HIV seropositive women attending an infectious diseases unit, based on an interview, physical examination, and laboratory screening for major sexually transmitted infections (STI). Cervicovaginal lavage fluid was tested for HIV-RNA by means of nested PCR. Links between cervicovaginal shedding of HIV-1 and HIV-2 and sociodemographic, clinical, and laboratory variables were identified by using odd ratios and 95% confidence intervals. Logistic regression analysis was used to identify independent links with HIV shedding. Results: The detection rate of HIV-RNA in cervicovaginal lavage fluid was low among FSW, with no difference between HIV-1 (7/90: 8%) and HIV-2 (3/48: 6%). The rate was far higher among the other women (41%, 48/117; 33%, 7/21 for HIV-1 and HIV-2, respectively). In multivariate analysis, high plasma viral load (>40 000 copies/ml) (AOR = 2.4 (1.0–5.6) p = 0.04) and basic vaginal pH (AOR = 2.2 (1.3–3.7) p = 0.002) were independently associated with HIV-1 shedding. For HIV-2 a CD4 count < 200 cells × 106/l was the only factor associated with the shedding of HIV-2 (AOR = 9.0 (0.9–93)). The genital shedding rate was higher with HIV-1 than with HIV-2 (OR = 2.1 (0.9–4.8), but this difference disappeared after adjustment for the CD4+ cell count (AOR = 1.2 (0.5–2.9)). Conclusion: Advanced disease stage and immunosuppression are the major risk determinants for shedding of both HIV-1 and HIV-2. Basic vaginal pH is also a risk determinant for HIV-1 shedding.
Do physiotherapists' attitudes towards evidence-based practice change as a result of an evidence-based educational programme?

RATIONALE The concept of evidence-based practice (EBP) encourages health care professionals to provide the most effective health care, and to be accountable for the interventions they provide. Little work has been undertaken to examine how practically allied health professionals' encompass EBP and how they perceptive and understand the concept of EBP. The use of opinion leaders to disseminate new evidence into practice, and thereby encourage the behaviour of health care professionals has been proposed. AIMS The aims of this study were to investigate physiotherapists' attitudes towards EBP and to examine change in their attitudes following an education package, which utilized local opinion leaders. METHOD Thirty musculoskeletal physiotherapists from a Community Trust in North Staffordshire were cluster randomized by location of work to two groups. The intervention group received an evidence-based programme on aspects of EBP including literature searching and critical appraisal. The attention control group received a standard in-service training package on the management of common knee pathologies. The physiotherapists' attitudes towards EBP were measured at baseline (before randomization) and at 3 and 6 months follow-up. RESULTS Physiotherapists reported that they primarily relied on 'courses' and 'in-service training' for informing their clinical practice. Most agreed that clinical practice should be based on the best available evidence and that they would change their clinical practice if evidence suggested they should do so. However, many of the physiotherapists reported difficulty in reading journals and could not identify opinion leaders in key areas. In terms of clinical practice, literature, journals and research were ascribed low priority throughout. Differences in attitudes between the intervention and control groups were observed in relation to management support for EBP at 3 and 6 months follow-up. CONCLUSIONS In this study, physiotherapists appeared to be in favour of the idea of EBP, yet they remained reluctant to change their practice. Opinion leaders were not easily identifiable by physiotherapists, suggesting that this method alone may not be an effective method of changing attitudes in clinical practice. The process of changing attitudes in the clinical environment is a complex issue worthy of further research.
Nephropathy and Retinopathy in Type 2 Diabetic Patients Living at Moderately High Altitude and Sea Level

Background: High-altitude-induced hypoxia results in various diseases, such as chronic mountain sickness and high altitude retinal edema, and may affect severity and incidence of some cardiovascular diseases. In order to evaluate the effects of moderately high altitude on diabetic nephropathy and retinopathy, a cross-sectional study was planned. Material Method: Long-term type II diabetic residents of sea level (n = 75, 38 male, 37 female, mean age 51.9 ± 10.5 in Trabzon and Zonguldak cities) and moderately high altitude (h = 1,727 m, n = 73, 28 male, 45 female, mean age 48.3 ± 12.1, Van city) were compared. Results: No difference was observed in terms of age, gender, diabetes duration, body mass index, smoking, systolic, diastolic, and mean arterial blood pressure values, serum glucose levels, cholesterol, high-density lipoprotein (HDL)-cholesterol, low-density lipoprotein (LDL)-cholesterol, hemoglobin, HbA1C, hypertension control, or blood pressure medications and retinopathy incidence. Mean 24 h protein excretion (210.0 ± 139.9, 127.8 ± 112.1 mg; P = 0.00), proteinuria prevalence (57.5% versus 33.3%, p = 0.003), and serum creatinine levels (1.04 ± 0.22 versus 0.84 ± 0.21, p = 0.00) were significantly higher in the highlanders, glomerular filtration rate (GFR) was significantly lower in sea level (SL) patients (90.9 ± 26.5 versus 83 ± 21.1, p = 0.05). Conclusion: Tendency to diabetic nephropathy as indicated by higher proteinuria and creatinine levels is increased among type 2 diabetic patients living at moderately high altitude. Prospective studies are needed to confirm these findings.