Miracle-dz/UniFAR-FTUs huggingface dataset:
Chiari-like malformation in the Griffon Bruxellois.

OBJECTIVES This study describes Chiari-like malformation and syringomyelia in the Griffon Bruxellois and establishes if skull radiographs are useful for disease prediction. METHODS Magnetic resonance imaging from 56 Griffon Bruxellois dogs was assessed for Chiari-like malformation and cerebrospinal fluid pathway abnormalities. Skull radiographs were obtained in 33 dogs. Two rostrocaudal and two ventrodorsal measurements were made, and ratios of one length to another were compared. RESULTS In this selected sample, 60.7 per cent had Chiari-like malformation. Syringomyelia occurred with and without Chiari-like malformation (37.5 and 8.9 per cent study population, respectively). The radiographic study demonstrated that one measurement ratio could be used to predict Chiari-like malformation (sensitivity of 87 per cent and specificity of 78 per cent) and that there were significant interaction factors between sex and syringomyelia for two measurement ratios. CLINICAL SIGNIFICANCE The study suggests that Chiari-like malformation is characterised by a shortening of the basicranium and supra-occipital bone with a compensatory lengthening of the cranial vault, especially the parietal bone. We described a simple radiographic technique, which may be useful as a screening test until a more definite genetic test for Chiari-like malformation is available.
Chronic Fatigue Syndrome – An occupational therapy programme

The cause of Chronic Fatigue Syndrome (CFS) is as yet undetermined; therefore, precise definitions for diagnosis and research have been developed. The most accepted diagnostic criteria are detailed below. It has been suggested that there are 150 000 cases of CFS in the UK, with a 2:1 predominance of females to males, and that prognosis without treatment is poor. The patterns of illness seen in CFS are identified and the development of an occupational therapy programme for the management of CFS is described.
Face learning with multiple images leads to fast acquisition of familiarity for specific individuals

Matching unfamiliar faces is a difficult task. Here we ask whether it is possible to improve performance by providing multiple images to support matching. In two experiments we observe that accuracy improves as viewers are provided with additional images on which to base their match. This technique leads to fast learning of an individual, but the effect is identity-specific: Despite large improvements in viewers’ ability to match a particular person's face, these improvements do not generalize to other faces. Experiment 2 demonstrated that trial-by-trial feedback provided no additional benefits over the provision of multiple images. We discuss these results in terms of familiar and unfamiliar face processing and draw out some implications for training regimes.
Masked suffix priming and morpheme positional constraints

Although masked stem priming (e.g., dealer–DEAL) is one of the most established effects in visual word identification, it is less clear whether primes and targets sharing a suffix (e.g., kindness–WILDNESS) also yield facilitation. In a new take on this issue, we show that prime nonwords facilitate lexical decisions to target words ending with the same suffix (sheeter–TEACHER) compared to a condition where the critical suffix was substituted by another one (sheetal–TEACHER) or by an unrelated nonmorphological ending (sheetub– TEACHER). We also show that this effect is genuinely morphological, as no priming emerged in noncomplex items with the same orthographic characteristics (sportel–BROTHEL vs. sportic–BROTHEL vs. sportur–BROTHEL). In a further experiment, we took advantage of these results to assess whether suffixes are recognized in a position-specific fashion. Masked suffix priming did not emerge when the relative order of stems and suffixes was reversed in the prime nonwords—ersheet did not yield any time saving in the identification of teacher as compared to either alsheet or obsheet. We take these results to show that –er was not identified as a morpheme in ersheet, thus indicating that suffix identification is position specific. This conclusion is in line with data on interference effects in nonword rejection and strongly constrains theoretical proposals on how complex words are identified. In particular, because these findings were reported in a masked priming paradigm, they suggest that positional constraints operate early, most likely at a prelexical level of morpho-orthographic analysis.
Developmental changes in misinterpretation of garden-path wh-questions in French

This study explores (mis)interpretation of biclausal wh-questions by French-speaking adults and children, aiming to investigate cross-linguistic differences in sentence revision mechanisms. Following previous work in Japanese the ambiguity of wh-questions was manipulated: In ambiguous questions, the fronted wh-phrase could be associated with the first, main-clause verb or the second, embedded-clause verb, while in garden-path questions, an inserted filled-gap prepositional phrase (PP) blocked main-clause attachment. Importantly, French differs from Japanese in that the filled gap arises after the first verb—that is, after the wh-phrase has been interpreted within the main clause. Two story-based comprehension experiments were conducted to probe the effect of word order on revision performance. Adults and children frequently provided main-clause interpretations of ambiguous questions. In filled-gap questions, children displayed relatively acute sensitivity to the filled-gap in wh-argument questions (Experiment 2), but not in wh-adjunct questions (Experiment 1); adults showed surprisingly low sensitivity to it, frequently misinterpreting adjunct and argument questions. Acceptability ratings (Experiment 3) showed that adults systematically prefer in situ questions over wh-fronting questions. We conclude that timing of the error signal influences revision, and that whereas French-speaking children prioritize syntactic cues, adults prioritize distributional information about the optionality of wh-fronting in French.
Inflected words in production: Evidence for a morphologically rich lexicon

Current evidence suggests that there is a difference between the representations of multimorphemic words in production and perception. In perception, it is widely believed that both whole-word and root representations exist, while in production there is little evidence for whole-word representations. The present investigation demonstrates that whole-word and root frequency independently predict the duration of words suffixed with –ing, –ed, and –s, which reveals that both root and word representations play a role in the production of inflected English words. In a second line of analysis, we find that the number of inflected phonological neighbours independently predicts the duration of monomorphemic words, which extends these results and suggests that whole-word representations exist at the lexical level. Together these results suggest that both root and word representations of inflected words are stored in the lexicon and are relevant for the production of both monomorphemic and multimorphemic words.
Judging the implications of a concession: Conversational distance and belief bias effects

An arguer's position at a given point in an argument can be characterized as a set of commitments. The present study considers the perceptions of ordinary language users about the implications of making a concession for the contents of the conceder's commitment set. In particular, we examine two sources of influence on such lay perceptions—conversational distance (i.e., the number of turns separating the concession from commitments incurred earlier in the argument) and an individual's prior beliefs regarding the content of the argument. Across two studies, college students were administered an argument task assessing the extent to which a concession by the protagonist of an argument on the last move indicated changes to other commitments incurred earlier in the argument. Results indicated that participants were more likely to judge a concession as indicating a change in prior commitments if (a) the commitment was incurred later in the argument than earlier, and (b) the participant disagreed with the protagonists’ thesis in the argument. In addition, performance on deductive reasoning tasks predicted individual differences in the conversational distance effect, but not the belief bias effect.
Perception of Occupational Therapists On Driving Rehabilitation

The purpose of this study is to provide some basic materials for the driving rehabilitation, by analyzing the presence and needs of the driving rehabilitation, which is recognized by the Occupational therapist. This study analyzed 83 survey questionnaires given to occupational therapist in Busan and Kyoung-nam. Most Occupational therapists does not receive lecture and education of driving rehabilitation, 62 Occupational therapist does not driving rehabilitation intervention. Most Occupational therapist mentioned driving rehabilitation needs. Driving rehabilitation influence on rehabilitation of clients and support activities of daily life.
Testing enhances both encoding and retrieval for both tested and untested items

In forward testing effects, taking a test enhances memory for subsequently studied material. These effects have been observed for previously studied and tested items, a potentially item-specific testing effect, and newly studied untested items, a purely generalized testing effect. We directly compared item-specific and generalized forward testing effects using procedures to separate testing benefits due to encoding versus retrieval. Participants studied two lists of Swahili–English word pairs, with the second study list containing “new” pairs intermixed with the previously studied “old” pairs. Participants completed a review phase in which they took a cued-recall test on only the “old” pairs or restudied them. In Experiments 1a, 1b, and 2, the review phase was given either before or after the second study list. Testing benefited memory to the same degree for both “new” and “old” pairs, suggesting that there were no pair-specific benefits of testing. The larger benefit from testing when review was given before rather than after the second study list suggests that the memory enhancement was due to both testing-enhanced encoding and testing-enhanced retrieval. To better equate generalized testing effects for “new” and “old” pairs, Experiment 3 intermixed them in the review phase. A statistically significant pair-specific testing effect for “old” items was now observed. Overall, these results show that forward testing effects are due to both testing-enhanced encoding and retrieval effects and that direct, pair-specific forward testing benefits are considerably smaller than indirect, generalized forward testing benefits.
Present status of the efficacy and tolerability of terbinafine (Lamisil) used systemically in the treatment of dermatomycoses of skin and nails

Lamid is a new antifungal drug which can be administered orrally and is effective against a broad range of dermatomycoses. This report summarizes its mycological and clinical cure rates in 32 clinical studies in which it was used orally for the treatment of tinea corporis, tinea pedis (both interdigital and plantar types), onychomycosis of fingernails and toenails, cutaneous candidiasis and pityriasis versicolor. The pharmacokinetic profile shows Lamisil to be distributed extensively into lipophilic tissue and to have an elimination half-life from plasma which allows effective oncedaily administration. It diffuses from the vascular system into the stratum corneum where it binds, reaching levels well above the fungicidal concentrations against dermatophytes and yeast. In the treatment of over 1000 patients it has been shown to be very effective, leading to clinical cure in all the dermatomycoses listed above except pityriasis versicolor. It was particularly, and uniquely, effective in the most chronic form.
Quantitative mapping of genetic similarity in human heritable diseases by shared mutations

Many genetic diseases exhibit considerable epidemiological comorbidity and common symptoms, which provokes debate about the extent of their etiological overlap. The rapid growth in the number of known disease‐causing mutations in the Human Gene Mutation Database (HGMD) has allowed us to characterize genetic similarities between diseases by ascertaining the extent to which identical genetic mutations are shared between diseases. Using this approach, we show that 41.6% of disease pairs in all possible pairs (42, 083) exhibit a significant sharing of mutations (P value < 0.05). These mutation‐related disease pairs are in agreement with heritability‐based disease–disease relations in 48 neurological and psychiatric disease pairs (Spearman's correlation coefficient = 0.50; P value = 3.4 × 10−5), and share over‐expressed genes significantly more often than unrelated disease pairs (1.5–1.8‐fold higher; P value ≤ 1.6 × 10−4). The usefulness of mutation‐related disease pairs was further demonstrated for predicting novel mutations and identifying individuals susceptible to Crohn disease. Moreover, the mutation‐based disease network concurs closely with that based on phenotypes.
A dystroglycan mutation (p.Cys667Phe) associated to muscle‐eye‐brain disease with multicystic leucodystrophy results in ER‐retention of the mutant protein

Dystroglycan (DG) is a cell adhesion complex composed by two subunits, the highly glycosylated α‐DG and the transmembrane β‐DG. In skeletal muscle, DG is involved in dystroglycanopathies, a group of heterogeneous muscular dystrophies characterized by a reduced glycosylation of α‐DG. The genes mutated in secondary dystroglycanopathies are involved in the synthesis of O‐mannosyl glycans and in the O‐mannosylation pathway of α‐DG. Mutations in the DG gene (DAG1), causing primary dystroglycanopathies, destabilize the α‐DG core protein influencing its binding to modifying enzymes. Recently, a homozygous mutation (p.Cys699Phe) hitting the β‐DG ectodomain has been identified in a patient affected by muscle‐eye‐brain disease with multicystic leucodystrophy, suggesting that other mechanisms than hypoglycosylation of α‐DG could be implicated in dystroglycanopathies. Herein, we have characterized the DG murine mutant counterpart by transfection in cellular systems and high‐resolution microscopy. We observed that the mutation alters the DG processing leading to retention of its uncleaved precursor in the endoplasmic reticulum. Accordingly, small‐angle X‐ray scattering data, corroborated by biochemical and biophysical experiments, revealed that the mutation provokes an alteration in the β‐DG ectodomain overall folding, resulting in disulfide‐associated oligomerization. Our data provide the first evidence of a novel intracellular mechanism, featuring an anomalous endoplasmic reticulum‐retention, underlying dystroglycanopathy.
Fine Motor Skills Enhance Lexical Processing of Embodied Vocabulary: A Test of the Nimble-Hands, Nimble-Minds Hypothesis

Research suggests that fine motor skills (FMS) are linked to aspects of cognitive development in children. Additionally, lexical processing advantages exist for words implying a high body–object interaction (BOI), with initial findings indicating that such words in turn link to children's FMS—for which we propose and evaluate four competing hypotheses. First, a maturational account argues that any links between FMS and lexical processing should not exist once developmental variables are controlled for. Second, functionalism posits that any link between FMS and lexical processing arises due to environmental interactions. Third, the semantic richness hypothesis argues that sensorimotor input improves lexical processing, but predicts no links between FMS and lexical processing. A fourth account, the nimble-hands, nimble minds (NHNM) hypothesis, proposes that having greater FMS improves lexical processing for high-BOI words. In two experiments, the response latencies of preschool children (n = 90, n = 76, ages = 5;1) to 45 lexical items encompassing high-BOI, low-BOI, and less imageable words were measured, alongside measures of FMS, reasoning, and general receptive/expressive vocabulary. High-BOI words appeared to show unique links to FMS, which remained after accounting for low-BOI and less imageable words, general vocabulary, reasoning, and chronological age. Although further work is needed, the findings provide initial support for the NHNM hypothesis.
Cis variants identified in F508del complex alleles modulate CFTR channel rescue by small molecules

Molecules correcting the trafficking (correctors) and gating defects (potentiators) of the cystic fibrosis causing mutation c. 1521_1523delCTT (p.Phe508del) begin to be a useful treatment for CF patients bearing p.Phe508del. This mutation has been identified in different genetic contexts, alone or in combination with variants in cis. Until now, 21 exonic variants in cis of p.Phe508del have been identified, albeit at a low frequency. The aim of this study was to evaluate their impact on the efficacy of CFTR‐directed corrector/potentiator therapy (Orkambi). The analysis by minigene showed that two out of 15 cis variants tested increased exon skipping (c.609C > T and c.2770G > A). Four cis variants were studied functionally in the absence of p.Phe508del, one of which was found to be deleterious for protein maturation c.1399C > T (p.Leu467Phe). In the presence of p.Phe508del, this variant was the only to prevent the response to Orkambi treatment. This study showed that some patients carrying p.Phe508del complex alleles are predicted to poorly respond to corrector/potentiator treatments. Our results underline the importance to validate treatment efficacy in the context of complex alleles.
Comparison of two shampoos for the treatment of canine Malassezia dermatitis: a randomised controlled trial.

OBJECTIVES Two antimicrobial shampoos for treatment of canine Malassezia dermatitis (CMD) were compared in a prospective, randomised, single-blinded, field clinical trial. METHODS Sixty-seven dogs with pedal or generalised dermatitis associated with Malassezia overgrowth (MO) were treated with 3% chlorhexidine shampoo (3%CHX) or 2% miconazole-2% chlorhexidine shampoo (2%MIC/CHX) and evaluated for up to 6 weeks until cytological recovery. Pruritus, erythema, papules, greasy seborrhoea, scaling, malodour, excoriations, secondary hairloss, lichenification, hyperpigmentation and lesion extent were each scored on a 0-3 severity scale and combined making an aggregate score. RESULTS Among 54 dogs with good treatment compliance, reduction of yeast counts by at least 88% was recorded in 21 of 22 dogs with 3%CHX and 30 of 32 dogs with 2%MIC/CHX. No significant difference was detected between products for yeast count reduction (P=0·592). Time to cytological recovery was not significantly different between groups (P=0·960). Lesion score was significantly reduced in both groups after treatment (72·5 ±25·7% with 3%CHX versus 78·7 ±22·3% with 2%MIC/CHX, P=0·309). Four dogs treated with chlorhexidine shampoo showed minor adverse effects. CLINICAL SIGNIFICANCE In this study, 3%CHX was clinically as effective as 2%MIC/CHX for treatment of CMD.
Stimulus dependence and cross-modal interference in sequence learning

A central issue in sequence learning is whether learning operates on stimulus-independent abstract elements, or whether surface features are integrated, resulting in stimulus-dependent learning. Using the serial reaction-time (SRT) task, we test whether a previously presented sequence is transferrable from one domain to another. Contrary to previous artificial grammar learning studies, there is mapping between pre- and posttransfer stimuli, but contrary to previous SRT studies mapping is not obvious. In the pre-transfer training phase, participants face a dot-counting task in which the location of the dots follows a predefined sequence. In the test phase, participants face an auditory SRT task in which the spatial organization of the response locations is either the same as spatial sequence in the training phase, or not. Sequence learning is compared to two control conditions: one with a non-sequential random-dot counting in the training phase, and one with no training phase. Results show that sequential training proactively interferes with later sequence learning, regardless of whether the sequence is the same or different in the two phases. Results argue for the existence of a general sequence processor with limited capacity, and that sequence structures and sequenced elements are integrated into a single sequential representation.
Baseball fans don’t like lumpy batters: Influence of domain knowledge on the access of subordinate meanings

Two experiments investigated the effects of domain knowledge on the resolution of ambiguous words with dominant meanings related to baseball. When placed in a sentence context that strongly biased toward the non-baseball meaning (positive evidence), or excluded the baseball meaning (negative evidence), baseball experts had more difficulty than non-experts resolving the ambiguity. Sentence contexts containing positive evidence supported earlier resolution than did the negative evidence condition for both experts and non-experts. These experiments extend prior findings, and can be seen as support for the reordered access model of lexical access, where both prior knowledge and discourse context influence the availability of word meanings.
DOUBLE-BLIND COMPARISON OF THE MORPHINE SPARING EFFECT OF CONTINUOUS AND INTERMITTENT I.M. ADMINISTRATION OF KETOROLAC

The morphine sparing effect of ketorolac 10 mg administered 4-hourly by intermittent i.m. injection was compared with a continuous i.m. infusion in a double-blind, placebo-controlled trial in patients undergoing upper abdominal surgery. During the 48-h postoperative period, each patient was provided with a patientcontrolled analgesia (PCA) system which delivered bolus doses of morphine and administered the intermittent i.m. doses automatically via a computer controlled pump. In the first 24 h after surgery, there was a significant reduction in morphine demanded by both groups receiving ketorolac compared with placebo. Patients who received a continuous infusion of ketorolac after abdominal surgery required a median dose of morphine by PCA which was 49% less than controls. In the second 24 h and over the entire 48 h of the study, patients in the continuous group required significantly less morphine than those in the placebo group. The intermittent group used less than the placebo group, but this was not significant.