Miracle-dz/UniFAR-FTUs huggingface dataset:
THE EFFECTS OF A COMMERCIALLY AVAILABLE WARM‐UP PROGRAM ON LANDING MECHANICS IN FEMALE YOUTH SOCCER PLAYERS

The purpose of this study was to examine lower extremity kinematics following implementation of the Sportsmetrics Warm-Up for Injury Prevention and Performance (WIPP) training program. The hypothesis was that there would be no difference in landing mechanics between 2 groups of female youth soccer players (9–11 years of age), with 1 group (Treatment) completing the 8-week–duration (2 days per week) WIPP program and the other serving as a Control group. We recruited 21 female youth soccer players. Treatment (n = 12) and Control (n = 9) groups were established. Using the Sportsmetrics Software for Analysis of Jumping Mechanics, we analyzed lower extremity movement during landing after subjects jumped off a 30.5-cm box and immediately went into a vertical jump. No significant changes in knee separation values were observed in the Treatment group after 8 weeks of WIPP training. The results indicate that 8 weeks of WIPP training did not significantly alter landing strategies.
Uneven distribution of urban green spaces in a coastal city in northwest Mexico

ABSTRACT Extent and distribution of urban green spaces (UGS) in Mazatlan (Mexico) are analysed using remote sensing and GIS techniques. Vegetated areas (2,270 ha), a third of the urban area in 2015, were reclassified into green spaces (GS), urban tree (UT) and open spaces (OS), based in the normalised difference vegetation index, relating them with demographic and socioeconomic data. UGS allocation per capita amount 55 m2, mainly represented by the UT class, with the largest patches associated with low developed and very high marginalised areas, and also with very low marginalised sectors, while the lowest allocation correspond to medium and low marginalisation, highly populated sector, without significant correlations. Despite the USG allocation, it is required a better urban planning to maintain public UGS and to protect the local flora, threatened by the introduction of exotic, ornamental species (64% of UT), to guarantee the provision of ecosystem services to the population.
Metabolic Correction Induced by Leptin Replacement Treatment in Young Children With Berardinelli-Seip Congenital Lipoatrophy

OBJECTIVE. Berardinelli-Seip syndrome is a rare congenital lipoatrophy with a severe prognosis and no efficient therapy. Children present with low leptin levels and severe metabolic complications (insulin resistance, elevated triglyceride levels, and hepatic steatosis). The objective of this study was to test safety and efficacy of recombinant-methionyl-human leptin replacement in children with Berardinelli-Seip syndrome before development of severe metabolic disease METHODS. As part of an open trial, recombinant-methionyl-human leptin was given daily for 4 months to children who did not have diabetes and had Berardinelli-Seip congenital lipoatrophy and metabolic complications at a dosage that was meant to achieve physiologic levels. Six boys and 1 girl (age: 2.4–13.6 years), with a mean fasting insulin level of >15 mIU/L and hypertriglyceridemia, were included. RESULTS. At the end of the recombinant-methionyl-human leptin treatment, a 63% reduction of fasting triglycerides level was achieved. A simultaneous 30% increase in insulin sensitivity was seen, and liver volume was reduced by 20.3%. More remarkable, values of insulin sensitivity and triglyceride level were in the reference range in 4 patients. CONCLUSIONS. Leptin replacement is able to reverse metabolic complications in the majority of children with Berardinelli-Seip congenital lipoatrophy and with insulin resistance or dyslipidemia before the development of overt diabetes.
RanBPM regulates the progression of neuronal precursors through M‐phase at the surface of the neocortical ventricular zone

Many of the mitoses that produce pyramidal neurons in neocortex occur at the dorsolateral surface of the lateral ventricles in the embryo. RanBPM was found in a yeast two‐hybrid screen to potentially interact with citron kinase (CITK), a protein shown previously to localize to the surface of the lateral ventricles and to be essential to neurogenic mitoses. Similar to its localization in epithelia, RanBPM protein is concentrated at the adherens junctions in developing neocortex. The biochemical interaction between CITK and RanBPM was confirmed in coimmunoprecipitation and protein overlay experiments. To test for a functional role of RanPBM in vivo, we used in utero RNAi. RanBPM RNAi decreased the polarization of CITK to the ventricular surface, increased the number of cells in mitosis, and decreased the number of cells in cytokinesis. Finally, the effect of RanBPM knockdown on mitosis was reversed in embryos mutant for CITK. Together, these results indicate that RanBPM, potentially through interaction with CITK, plays a role in the progression of neocortical precursors through M‐phase at the ventricular surface. © 2009 Wiley Periodicals, Inc. Develop Neurobiol, 2010
The comparison of Ethibond sutures and semitendinosus autograft in the surgical treatment of acromioclavicular dislocation.

OBJECTIVE The aim of this study was to compare the results of the surgical reconstruction of the acromioclavicular joint (ACJ) dislocations using No. 5 Ethibond suture or semitendinosus autograft. METHODS This analytical cross-sectional study was conducted on the medical records of 39 patients (35 males and 4 females; mean age: 32.6±11.8 years), with complete ACJ joint dislocation (Type 3 to 6). Twenty one patients underwent reconstruction using No. 5 Ethibond suture (Group A) and 18 patients using semitendinosus tendon autograft (Group B). The patients' database records were queried for the information regarding the evaluations during follow-up period (mean: 25.7 months) such as radiographic evaluations, Constant score, VAS score and infection. RESULTS The mean Constant score was 91±1 and 92±2.1 in Groups A and B, respectively. There was a reduction of ACJ based on Zanca view in 15 patients in Group A and 12 patients in Group B. There was subluxation of ACJ by less than 25% in six patients in Group A and five in Group B, in that, the difference was not significant. Patients expressed acceptable satisfaction and equal pain severity in rest and daily activity in both groups. No deep infection has been observed. CONCLUSION Since both surgical techniques led to satisfactory results, reduction of ACJ, excellent functional score and acceptable patient satisfaction, No. 5 Ethibond suture technique could be recommended as the treatment of choice due to the absence of morbidity in removing semitendinosus autograft tendon.
Quadrivalent meningococcal serogroups A, C, W, and Y tetanus toxoid conjugate vaccine (MenACWY-TT): a review

Introduction: Meningococcal disease poses serious health risks globally. The six Neisseria meningitidis serogroups responsible for most of the disease burden are A, B, C, W, X and Y. The case fatality rate remains high worldwide and prevention by vaccination remains the best strategy. Because polysaccharide vaccines are poorly immunogenic in young children, conjugated vaccines were developed to overcome this drawback. The quadrivalent meningococcal conjugate vaccine (MenACWY-TT), comprising the serogroups A, C, W and Y conjugated to tetanus toxoid carrier protein (marketed under the trade name Nimenrix™), is the first quadrivalent vaccine to be approved in Europe as a single dose for ages 12 months and in Canada for ages 12 months to 55 years. Areas covered: This review addresses the limitations posed by polysaccharide vaccines, compares them with the MenACWY-TT conjugated alternative, and focuses on the clinical studies that investigate the immunogenicity and reactogenicity of MenACWY-TT in various age groups and its co-administration with other vaccines compatible with each age group. Expert opinion: Evidence suggests that MenACWY-TT has a good immunogenicity profile across a broad age range including toddlers, children, adolescents, and adults. It also has an acceptable safety profile and is well tolerated when administered with other vaccines.
Validity and reliability of self-monitoring indices

Primary objective: This research concerns the measurement of self-monitoring in people who were diagnosed with traumatic brain injury (TBI), learning disability (LD) and emotional disorder (ED). Two measures of self-monitoring were evaluated: (1) the correlation between participants’ self-predicted and observed standardized sub-test scores (R) on 17 WAIS-III 1 sub-tests and (2) the average difference between the participants’ predicted and observed sub-tests scores (B). It was then determined if these measures could discriminate the three diagnostic groups. Research design: Canonical analysis assessed the relationship between the self-monitoring measures and four WAIS-III IQ measures. This study also evaluated if the R and B measures could discriminate the diagnostic groups. Methods and procedures: One hundred and twenty-four participants, 42 with TBI, 42 with LD and 40 with ED predicted their performance on 17 WAIS-III sub-tests. Main outcomes and results: Canonical analysis demonstrated a significant relationship between the R and B measures and four WAIS-III IQ measures. Results of a MANOVA showed that the R and B measures differed significantly among the diagnostic groups. Conclusions: The R and B measures are two valid and reliable indices of self-monitoring that can be conveniently estimated from the WAIS-III.
Graft-Protective Effects of the HMG-CoA Reductase Inhibitor Pravastatin After Lung Transplantation— A Propensity Score Analysis With 23 Years of Follow-Up

Background. To determine whether the hydroxy-3-methylglutaryl coenzyme A reductase inhibitor pravastatin has a graft-protective effect, we retrospectively analyzed 502 patients who had undergone lung transplantation in Hannover. Methods. Propensity scores have been calculated for each patient and compared between two groups. Cox Hazard analyses were performed for different parameters (e.g., basic parameters of patients, underlying diagnoses, different operations, and important organ functions after lung transplantation). Lung function after transplantation was monitored using repeated measurement analyses. Additionally, conditional Kaplan-Meier survival analyses were used to explore the impact of different diagnoses, the severity of bronchiolitis obliterans, the type of transplantation, and different immunosuppressant regimes on patient survival. Results. The results indicate a strong association between the postoperative administration of statins and the improvement of survival, maintenance of graft (lung) function, and slowing of the onset of bronchiolitis obliterans. Conclusion. These findings suggest a new postoperative therapeutic focus for maintaining graft function.
Automatic Fetal Head Circumference Measurement in Ultrasound Using Random Forest and Fast Ellipse Fitting

Head circumference (HC) is one of the most important biometrics in assessing fetal growth during prenatal ultrasound examinations. However, the manual measurement of this biometric by doctors often requires substantial experience. We developed a learning-based framework that used prior knowledge and employed a fast ellipse fitting method (ElliFit) to measure HC automatically. We first integrated the prior knowledge about the gestational age and ultrasound scanning depth into a random forest classifier to localize the fetal head. We further used phase symmetry to detect the center line of the fetal skull and employed ElliFit to fit the HC ellipse for measurement. The experimental results from 145 HC images showed that our method had an average measurement error of 1.7 mm and outperformed traditional methods. The experimental results demonstrated that our method shows great promise for applications in clinical practice.
Activated Neural Stem Cells Contribute to Stroke-Induced Neurogenesis and Neuroblast Migration toward the Infarct Boundary in Adult Rats

Stroke increases neurogenesis. The authors investigated whether neural stem cells or progenitor cells in the adult subventricular zone (SVZ) of rats contribute to stroke-induced increase in neurogenesis. After induction of stroke in rats, the numbers of cells immunoreactive to doublecortin, a marker for immature neurons, increased in the ipsilateral SVZ and striatum. Infusion of an antimitotic agent (cytosine-β-D-arabiofuranoside, Ara-C) onto the ipsilateral cortex eliminated more than 98% of actively proliferating cells in the SVZ and doublecortin-positive cells in the ipsilateral striatum. However, doublecortin-positive cells rapidly replenished after antimitotic agent depletion of actively proliferating cells. Depleting the numbers of actively proliferating cells in vivo had no effect on the numbers of neurospheres formed in vitro, yet the numbers of neurospheres derived from stroke rats significantly (P < 0.05) increased. Neurospheres derived from stroke rats self-renewed and differentiated into neurons and glia. In addition, doublecortin-positive cells generated in the SVZ migrated in a chainlike structure toward ischemic striatum. These findings indicate that in the adult stroke brain, increases in recruitment of neural stem cells contribute to stroke-induced neurogenesis, and that newly generated neurons migrate from the SVZ to the ischemic striatum.
Biomass allocation and leaf chemical defence in defoliated seedlings of Quercus serrata with respect to carbon-nitrogen balance.

BACKGROUND AND AIMS Both nutrient availability and defoliation affect the carbon-nutrient balance in plants, which in turn influences biomass allocation (e.g. shoot-to-root ratio) and leaf chemical composition (concentration of nitrogen and secondary compounds). In this study it is questioned whether defoliation alters biomass allocation and chemical defence in a similar fashion to the response to nutrient deficiency. METHODS Current-year seedlings of Quercus serrata were grown with or without removal of all leaves at three levels of nutrient availability. KEY RESULTS Plant nitrogen concentration (PNC), a measure of the carbon-nutrient balance in the plant, significantly decreased immediately after defoliation because leaves had higher nitrogen concentrations than stems and roots. However, PNC recovered to levels similar to or higher than that of control plants in 3 or 6 weeks after the defoliation. Nitrogen concentration of leaves produced after defoliation was significantly higher than leaf nitrogen concentration of control leaves. Leaf mass per plant mass (leaf mass ratio, LMR) was positively correlated with PNC but the relationship was significantly different between defoliated and control plants. When compared at the same PNC, defoliated plants had a lower LMR. However, the ratio of the leaf to root tissues that were newly produced after defoliation as a function of PNC did not differ between defoliated and control plants. Defoliated plants had a significantly lower concentration of total phenolics and condensed tannins. Across defoliated and control plants, the leaf tannin concentration was negatively correlated with the leaf nitrogen concentration, suggesting that the amount of carbon-based defensive compounds was controlled by the carbon-nutrient balance at the leaf level. CONCLUSIONS Defoliation alters biomass allocation and chemical defence through the carbon-nutrient balance at the plant and at the leaf level, respectively.
Quantum melting of the hole crystal in the spin ladder of Sr(14-x)CaxCu24O41.

We have used resonant soft x-ray scattering to study the effects of discommensuration on the hole Wigner crystal (HC) in the spin ladder Sr(14-x)CaxCu24O41 (SCCO). As the hole density is varied the HC forms only with the commensurate wave vectors L(L) = 1/5 and L(L) = 1/3; for incommensurate values it "melts. " A simple scaling between L(L) and temperature is observed, tau1/3/tau1/5 = 5/3, indicating an inverse relationship between the interaction strength and wavelength. Our results suggest that SCCO contains hole pairs that are crystallized through an interplay between lattice commensuration and Coulomb repulsion, reminiscent of the "pair density wave" scenario.
Carnitine Disposition Before and During Valproate Therapy in Patients with Epilepsy

Summary: Free and total carnitine and acylcarnitine in plasma and urine samples was measured in 22 epileptic patients before and after 15 and 45 days of valproate (VPA) therapy and in 16 healthy volunteers on a single occasion. Carnitine plasma concentration and renal excretion observed in epileptic patients before VPA therapy did not differ from control values. After VPA was started, free and total plasma concentration decreased significantly (p < 0.05) from 49 ± 17 to 35 ± 16 at 15 days and to 35 ± 13 nmol/ml at 45 days of therapy (free carnitine) and from 60 ± 18 to 50 ± 18 at 15 days and to 55 ± 14 nmol/ml at 45 days of therapy (total carnitine), whereas acylcarnitine increased significantly (p < 0.05) from 10 ± 8 to 14 ± 8 at 15 days and to 18 ± 16 nmol/ml at 45 days of therapy. Free carnitine urinary excretion decreased significantly (p < 0.05) from 200 ± 135 to 115 ± 76 and 118 ± 75 μmol/24 h, whereas acylcarnitine urinary excretion increased significantly (p < 0.05) from 78 ± 56 to 154 ± 98 and 155 ± 89 μmol/24 h after VPA therapy was started. As a consequence, acylcarnitine renal clearance increased significantly (+ 30%, p < 0.05) whereas free carnitine renal clearance did not change during VPA therapy. No difference was detected between 15 and 45 days of therapy. No patients experienced symptoms of VPA toxicity. Our results suggest that VPA in patients increases both formation and renal clearance of acylcarnitine.
Is there a temporal trend in the reported treatment efficacy of periodontal regeneration? A meta-analysis of randomized-controlled trials.

BACKGROUND/AIM The aim of study was to conduct a meta-analysis to investigate whether or not there was a temporal trend in the treatment efficacy reported in the randomized-controlled trials (RCTs) on guided tissue regeneration (GTR) or enamel matrix protein derivatives (EMD) in the treatment of infrabony defects. MATERIAL AND METHODS The treatment outcomes were changes in probing pocket depth (PPD) and clinical attachment level (CAL). Weighted multilevel and ordinary regression analyses were performed to test the temporal relationship between treatment effect difference or treatment effectiveness and publication years. RESULTS For PPD reduction, non-significant positive relationships were found in the treatment effect difference or treatment effect of both GTR and flap operation. For CAL gain, a small positive relationship was found in the treatment effect difference, but a significant positive trend in the treatment effect of flap operation was found. No significant temporal trend was found in the treatment effect difference for EMD. CONCLUSIONS There was no evidence to support or refute a temporal trend in the treatment effect of regenerative procedures, but a positive trend was observed in the control group. These results suggest that only RCTs should be included in the meta-analysis, as the treatment effect of the control group may not be constant.
Étude qualitative sur le point de vue des personnes âgées et des aidants naturels quant à l ’ évaluation et au traitement de la douleur

La documentation disponible donne à penser que la douleur chez les personnes âgées, en particulier celles atteintes de démence, est sous-évaluée et sous-traitée. Dans le cadre de cette étude qualitative, des personnes âgées, du personnel infirmier de première ligne, des administrateurs de résidences pour personnes âgées et des aidants naturels de personnes âgées souffrant de démence donnent leur point de vue sur la manière dont on évalue et on traite actuellement la douleur. L’opinion des participants complète les résultats de recherche cités dans la documentation. Même si certaines explications et solutions possibles concernant le sous-traitement de la douleur chez les personnes âgées font écho aux points de vue exprimés dans la documentation, les participants ont également mentionné des facteurs et des solutions qui ont été pris en compte de manière moins formelle, comme les obstacles systémiques à une évaluation et un traitement efficaces de la douleur. Ils ont également souligné la nécessité d’avoir d’autres stratégies en plus de la médication pour contrôler la douleur. Cette étude examine l’impact de ces résultats.
A clinical trial of the accuracy and treatment experience of the Dexcom G4 sensor (Dexcom G4 system) and Enlite sensor (guardian REAL-time system) tested simultaneously in ambulatory patients with type 1 diabetes.

BACKGROUND Continuous glucose monitoring (CGM) is a tool widely used in the treatment of patients with type 1 diabetes. The purpose of the current study was to evaluate whether accuracy and patient treatment satisfaction differ between the Enlite™ (Medtronic MiniMed, Inc., Northridge, CA) and Dexcom(®) (San Diego, CA) G4 PLATINUM CGM sensors. SUBJECTS AND METHODS Thirty-eight ambulatory patients with type 1 diabetes used the Dexcom G4 and Enlite sensors simultaneously for a minimum of 4 and maximum of 6 days. Patients measured capillary glucose levels with a HemoCue(®) (Ängelholm, Sweden) system six to 10 times a day. In addition, two inpatient studies were performed between Days 1-3 and 4-6. RESULTS The mean absolute relative difference (MARD) in blood glucose for the Dexcom G4 was significantly lower (13.9%) than for the Enlite sensor (17.8%) (P<0.0001). The corresponding MARDs for Days 1-3 were 15.0% versus 19.4% (P=0.0027) and 13.6% versus 15.9% (P=0.026) for Days 4-6. For glucose levels in the hypoglycemic range (<4.0 mmol/L), the MARD for the Dexcom G4 was 20.0% compared with 34.7% for the Enlite (P=0.0041). On a visual analog scale (VAS) (0-100), patients rated the Dexcom G4 more favorably than the Enlite in 12 out of the 13 user experience questions. For example, more patients rated their experience with the Dexcom G4 as positive (VAS, 79.7 vs. 46.6; P<0.0001) and preferred to use it in their daily lives (VAS, 79.1 vs. 42.1; P<0.0001). CONCLUSIONS The Dexcom G4 sensor was associated with greater overall accuracy than the Enlite sensor during initial (Days 1-3) and later (Days 4-6) use and for glucose levels in the hypoglycemic range. Patients reported a significantly more positive experience using the Dexcom G4 than the Enlite.
Bacteriophage lambda vector for transducing a cDNA clone library into mammalian cells

We have developed a bacteriophage lambda vector (lambda NMT) that permits efficient transduction of mammalian cells with a cDNA clone library constructed with the pcD expression vector (H. Okayama and P. Berg, Mol. Cell. Biol. 3:280-289, 1983). The phage vector contains a bacterial gene (neo) fused to the simian virus 40 early-region promoter and RNA processing signals, providing a dominant-acting selectable marker for mammalian transformation. The phage DNA can accommodate pcD-cDNA recombinants with cDNA of up to about 9 kilobases without impairing the ability of the phage DNA to be packaged in vitro and propagated in vivo. Transfecting cells with the lambda NMT-pcD-cDNA recombinant phage yielded G418-resistant clones at high frequency (approximately 10(-2]. Cells that also acquired a particular cDNA segment could be detected among the G418-resistant transformants by a second selection or by a variety of screening protocols. Reconstitution experiments indicated that the vector could transduce 1 in 10(6) cells for a particular phenotype if the corresponding cDNA was present as 1 functional cDNA clone per 10(5) clones in the cDNA library. This expectation was confirmed by obtaining two hypoxanthine-guanine phosphoribosyltransferase (HPRT)-positive transductants after transfecting 10(7) HPRT-deficient mouse L cells with a simian virus 40-transformed human fibroblast cDNA library incorporated into the lambda NMT phage vector. These transductants contained the human HPRT cDNA sequences and expressed active human HPRT.