Miracle-dz/UniFAR-FTUs huggingface dataset:
Phase II evaluation of IPI-926, an oral Hedgehog inhibitor, in patients with myelofibrosis

Abstract The clinical safety and efficacy of IPI-926 was evaluated in 14 patients with myelofibrosis in a phase II study. Patients received 160 mg IPI-926 orally in continuous 28-day cycles. The median treatment duration was 5.1 months, and all patients had discontinued treatment by 7.5 months. Nine patients discontinued due to lack of response as determined by the treating physician, two after developing acute leukemia and one due to disease progression/loss of response. Twelve patients had slight reductions in spleen size (less than 50% from baseline), but symptoms did not improve consistently. One patient achieved transfusion independence lasting 5 months. Reductions in GLI1 mRNA and protein levels, JAK2V617F allele burden, degree of fibrosis or cytokine levels were observed in some patients, but were not significant when evaluated for the cohort. Low-grade gastrointestinal/liver abnormalities were the most common toxicities. The results did not support continued evaluation of IPI-926 as a monotherapy in myelofibrosis.
Enseigner l'anglais de l'école au collège : comment aborder les principaux obstacles à l'apprentissage

Fruit de nombreuses annees de recherche a l'INRP sur les debuts de l'apprentissage d'une langue etrangere en milieu scolaire, cet ouvrage propose des demarches pedagogiques innovantes visant a faciliter l'apprentissage de la langue etrangere. Il se concentre sur les principaux obstacles linguistiques rencontres par les eleves, sources d'erreurs systematiques et recurrentes tout au long du cursus. Il est constitue de dossiers pedagogiques directement exploitables en classe, unifies par une meme demarche de reflexion sur le francais et l'anglais. L'originalite de ces dossiers reside dans l'articulation etroite entre approche reflexive rigoureuse des phenomenes langagiers et pratique intensive et immediate de la langue etrangere. A travers les sequences d'enseignement proposees, sont fournis de nombreux elements destines a accroitre la qualite de l'enseignement, a ameliorer le cursus de l'eleve en anglais et, plus particulierement, le passage du cours moyen a la classe de 6e du college.
Spontaneously Healed Asymptomatic Pulmonary Tuberculosis: Prevalence of Airflow Obstruction, and Correlation Between High-Resolution CT Findings and Pulmonary Function Tests

Rationale and Objectives We investigated the relationships between spontaneously healed asymptomatic pulmonary tuberculosis (SHAPTB), airflow obstruction (AFO), and high-resolution computed tomography (HRCT) findings. Materials and Methods We selected 82 participants with SHAPTB diagnosed by interferon-&ggr; release assay and 8044 with normal chest radiographs (CXR). We applied a CT scoring system for the extent of tuberculous sequelae to correlate the HRCT findings with pulmonary function test. We compared the AFO prevalence between subjects with and without SHAPTB. Results The subjects with SHAPTB diagnosed by interferon-&ggr; release assay had a significantly higher prevalence of AFO (13.4% [11/82]) than those with normal CXR (7.4% [595/8044]). The important HRCT findings that correlated with AFO were the number of lung segments with TB sequelae and the CT score for emphysema. Conclusion The subjects with SHAPTB had a higher AFO prevalence than those with normal CXR, and the important HRCT findings correlated with AFO were the extent of tuberculous sequelae and emphysema.
Multi-User Transmissions for Relay Networks with Linear Complexity

This paper considers transmission and detection schemes in a (J, R, N) multi-access relay network (MARN), where J single-antenna source nodes send independent messages to one N-antenna destination node through one R-antenna relay node. For complexity considerations, the network is under two linear constraints. The relay node linearly maps its received signals to generate the forwarded signals without decoding and the destination node has linear decoding complexity in the number of users. We propose two protocols to allow multi-user concurrent transmission in the network. Using distributed space-time coding (DSTC) at the relay and zero-forcing interference cancellation (IC) at the receiver, the protocol of DSTC-ICRec allows concurrent transmission in both the source-relay link and the relay-receiver link. When J = 2J-1, TDMA-ICRec achieves the maximum interference-free (int-free) diversity of R, at a lower symbol rate compared to DSTC-ICRec.
Neurochemical biomarkers in Alzheimer’s disease and related disorders

Neurochemical biomarkers for diagnosing dementias are currently under intensive investigation and the field is rapidly expanding. The main protagonists and the best defined among them are cerebrospinal fluid levels of Aβ42, tau and its phosphorylated forms (p-tau). In addition, novel cerebrospinal fluid biomarkers are emerging and their multiparametric assessment seems most promising for increasing the accuracy in neurochemical dementia diagnostics. The combined assessment of Aβ42 and p-tau has recently shown value for diagnosing prodromal states of Alzheimer’s dementia, that is, mild cognitive impairment. Disease-specific biomarkers for other degenerative dementias are still missing, but some progress has recently been made. As lumbar puncture is an additional burden for the patient, blood-based neurochemical biomarkers are definitely warranted and promising new discoveries have been made in this direction. These diagnostic developments have implicit therapeutic consequences and give rise to new requirements for future neurochemical dementia diagnostics.
Characterizing traditionally defined periodontal disease in HIV+ adults.

BACKGROUND Results have varied from previous studies examining the level and extent of periodontal disease (PD) in HIV-1 infected (HIV+) adults. These studies used different methodologies to measure and define PD and examined cohorts with divergent characteristics. Inconsistent methodological approaches may have resulted in the underestimation of traditionally-defined PD in HIV+ individuals. OBJECTIVES To characterize the level, extent and predictors (i.e. immunologic, microbiologic, metabolic and behavioral) of PD in an HIV+ cohort during the era of highly active antiretroviral therapy (HAART). STUDY DESIGN Cross-sectional study. SETTING HIV+ adults receiving outpatient care at three major medical clinics in Cleveland, OH. Subjects were seen from May, 2005 to January, 2008. MEASUREMENTS Full-mouth periodontal examinations included periodontal probing depth (PPD), recession (REC) and clinical attachment level (CAL). Subgingival plaque was assessed for DNA levels of Porphyromonas gingivalis (Pg), Tannerella forsythia, and Treponema denticola by real-time DNA PCR assays developed for each pathogen. Rather than using categories, we evaluated PD as three continuous variables based on the percent of teeth with >or=1 site per tooth with PPD >or= 5mm, REC > 0 mm and CAL >or= 4mm. RESULTS Participants included 112 HIV+ adults. Each subject had an average 38% (+/-24%) of their teeth with at least one site of PD >or= 5 mm, 55% (+/-31%) of their teeth with at least one site of REC > 0 mm, and 50% (+/-32%) of their teeth with at least one site of CAL >or= 4 mm. CD4+ T-cell count <200 cells/mm(3) was significantly associated with higher levels of REC and CAL, but not PPD. Greater levels of Pg DNA were associated with PPD, REC and CAL.By regression analysis, CD4+ T-cell count <200 cells /mm3 had approximately twice thedeleterious effect on CAL as did smoking (standardized beta coefficient 0.306 versus 0.164) [corrected]. Annual dental visit compliance remained an independent predictor for lower levels of PD. CONCLUSIONS The level and extent of PD were high in this cohort even though most patients were being treated with HAART. The definition of periodontal disease used and cohort characteristics examined can influence the level of periodontal disease reported in studies of persons with HIV. Traditional periodontal pathogens are associated with PD in this cohort. Those with CD4+ T-cell counts <200 cells/mm(3) are at greater risk for PD. Therefore, earlier HAART initiation may decrease exposure to immunosuppression and reduce PD morbidity. Continuity of dental care remains important for HIV+ patients even when they are being treated with HAART.
Restoring Point-of-Care Testing during Parathyroidectomy with a Newer Parathyroid Hormone Assay

Objective. Intraoperative parathyroid hormone (IOPTH) monitoring has emerged as a useful adjunct in parathyroidectomy. Originally performed within the operating room, removal of the Nichols assay from the market forced many surgeons to rely on testing done in central laboratories, reducing convenience and prolonging operative times. The authors hypothesized that PTH assessment with a newer point-of-care (POC) assay would reduce results reporting time compared with central-laboratory PTH assays. Study Design. Cross-sectional study with planned data collection. Setting. Academic medical center. Subjects and Methods. Patients underwent parathyroidectomy for primary or recurrent hyperparathyroidism. Intraoperative monitoring of serum PTH levels was used to confirm biochemical cure following adenoma excision. Samples were run in duplicate using both a POC PTH assay (Future Diagnostics) located within the operating room and a laboratory-based assay (Turbo PTH). Samples were taken at incision and at 5-, 10-, and 15-minute intervals following removal of suspected parathyroid adenomas. Results reporting time was recorded and compared by nonparametric Wilcoxon rank sum test. Results. Sixty-six serum samples were assayed. There was excellent correlation between POC and central-laboratory IOPTH results (r = 0.880, P < .001). The POC IOPTH results were available faster than corresponding central-laboratory results, with a mean of 14.4 minutes compared with 30.7 minutes, respectively (P < .001). All patients (100%) demonstrated a biochemical cure by the end of the procedure. Conclusion. Use of a rapid POC IOPTH assay results in a significant decrease in the amount of time for laboratory results to be communicated to the surgical team. This reduces operative times for parathyroidectomy and improves patient care.
The experiential basis of meaning

How are abstract ideas acquired and structured? One idea is that people’s understanding of abstract domains is constructed using more basic, experiential knowledge that is acquired directly. For instance, a series of studies (Boroditsky 2000, Boroditsky & Ramscar, 2002) has shown that people’s understanding of time supervenes on their physical conceptions of space, to the extent that manipulations of people’s spatial knowledge have predictable affects on their temporal reasoning. In this paper we explore just how widespread this phenomenon is. To see whether basing abstract knowledge on concrete knowledge is a pervasive aspect of cognition, we investigate whether thought about an abstract, non-literal type of motion called fictive motion (Matlock, 2003a; Talmy, 1996) can influence the way people understand time. Our results suggest that, contrary to previous claims (Jackendoff, 2002), abstract, metaphorical knowledge about motion involves the same structures used in understanding literal motion, and that the activation of these “literal” aspects of fictive motion serve to influence temporal reasoning. The results provide further evidence of the intimate connection between abstract and concrete knowledge.
Nuclear Import of the Retrotransposon Tf1 Is Governed by a Nuclear Localization Signal That Possesses a Unique Requirement for the FXFG Nuclear Pore Factor Nup124p

ABSTRACT Retroviruses, such as human immunodeficiency virus, that infect nondividing cells generate integration precursors that must cross the nuclear envelope to reach the host genome. As a model for retroviruses, we investigated the nuclear entry of Tf1, a long-terminal-repeat-containing retrotransposon of the fission yeastSchizosaccharomyces pombe. Because the nuclear envelope of yeasts remains intact throughout the cell cycle, components of Tf1 must be transported through the envelope before integration can occur. The nuclear localization of the Gag protein of Tf1 is different from that of other proteins tested in that it has a specific requirement for the FXFG nuclear pore factor, Nup124p. Using extensive mutagenesis, we found that Gag contained three nuclear localization signals (NLSs) which, when included individually in a heterologous protein, were sufficient to direct nuclear import. In the context of the intact transposon, mutations in the NLS that mapped to the first 10 amino acid residues of Gag significantly impaired Tf1 retrotransposition and abolished nuclear localization of Gag. Interestingly, this NLS activity in the heterologous protein was specifically dependent upon the presence of Nup124p. Deletion analysis of heterologous proteins revealed the surprising result that the residues in Gag with the NLS activity were independent from the residues that conveyed the requirement for Nup124p. In fact, a fragment of Gag that lacked NLS activity, residues 10 to 30, when fused to a heterologous protein, was sufficient to cause the classical NLS of simian virus 40 to require Nup124p for nuclear import. Within the context of the current understanding of nuclear import, these results represent the novel case of a short amino acid sequence that specifies the need for a particular nuclear pore complex protein.
Effect of flower and fruit thinning on maturity, yield and quality of plum (Prunus salicina Lindl) cv. Satluj purple

Chemical thinners namely ammonium thiosulphate (1.5 and 2.5%) at 50 per cent flowering and at full bloom stage; urea (4 and 6%) at full bloom and ethrel (50,100 and 150 ppm) before pit hardening stage of the fruits were applied in plum cv. Satluj Purple. Hand thinning of the fruitlets was done before pit hardening stage. Ammonium thiosulphate at 1.5 per cent was found to be the most effective treatment to reduce the crop load, followed by hand thinning. Maturity was advanced by 2 days with ethrel 100 ppm. Maximum yield, fruit weight, TSS, TSS/acid ratio, total sugars and reducing sugars were recorded with ethrel 100 ppm, followed by hand thinning. Ethrel 100 ppm applied before pit hardening stage was the best treatment as it advanced fruit maturation, reduced the crop load and increased the yield of superior quality fruits. Hand thinning of the fruitlets before pit hardening stage was the next best treatment.
Fowler-Nordheim Plot Analysis: A Progress Report

The commonest method of characterizing a cold field electron emitter is to measure its current-voltage characteristics, and the commonest method of analysing these characteristics is by means of a Fowler-Nordheim (FN) plot. This tutorial/review-type paper outlines a more systematic method of setting out the Fowler-Nordheim-type theory of cold field electron emission, and brings together and summarises the current state of work by the authors on developing the theory and methodology of FN plot analysis. This has turned out to be far more complicated than originally expected. Emphasis is placed in this paper on: (a) the interpretation of FN-plot slopes, which is currently both easier and of more experimental interest than the analysis of FN-plot intercepts; and (b) preliminary explorations into developing methodology for interpreting current-voltage characteristics when there is series resistance in the conduction path from the high-voltage generator to the emitter's emitting regions. This work reinforces our view that FN-plot analysis is best carried out on the raw measured current-voltage data, without pre-conversion into another data format, particularly if series resistance is present in the measuring circuit. Relevant formulae are given for extracting field-enhancement-factor values from such an analysis.
Toxicity associated with the long-term use of targeted therapies in patients with advanced renal cell carcinoma

VEGF and mTOR inhibitors have encouraging clinical activity for patients with advanced renal cell carcinoma (RCC), but may lead to significant short- and long-term toxicities. Although 40–70% of adverse events (AEs) are grade 1 and 2, 10–20% of patients develop grade 3 or 4 AEs requiring dose reductions, drug holidays or treatment discontinuation. The long-term impact of the most common grade 3 and 4 AEs observed in Phase III trials evaluating VEGF and mTOR inhibitors, including hypertension, decreased left ventricular ejection fraction, hand–foot-syndrome and myelosuppression, are a concern in RCC patients who are living longer and receiving chronic sequential or combination therapy. There is a clear need to develop a more rational way to individualize therapy for RCC. Long-term follow-up from existing Phase II/III trials should provide us with increased understanding of the potential implications of AEs in RCC patients. Prevention, early recognition and aggressive management of side effects are fundamental to avoid significant long-term complications and unnecessary dose reductions, which can ultimately reduce the efficacy of these novel agents.
Integrating VSCs to Weak Grids by Nonlinear Power Damping Controller With Self-Synchronization Capability

This paper presents a new control topology to enable effective integration of voltage source converters (VSCs) in weak grids. The controller has two main parts. The first part is a linear power-damping and synchronizing controller which automatically synchronizes a VSC to a grid by providing damping and synchronizing power components, and enables effective full power injection even under very weak grid conditions. The controller adopts cascaded angle, frequency and power loops for frequency and angle regulation. The controller emulates the dynamic performance of synchronous machines, which eases grid integration and provides a virtual inertia control framework for VSCs to damp power and frequency oscillations. Although the linear controller offers stable and smooth operation in many cases, it cannot ensure system stability in weak grids, where sudden large disturbances rapidly drift system dynamics to the nonlinear region. To overcome this difficulty, a supplementary nonlinear controller is developed to assist the linear controller and enhance system performance under large-signal nonlinear disturbances, such as self-synchronization, disturbances in grid frequency and angle, high power injection in very weak grids and fault-ride-through conditions.
Meridional Location of the Pacific Ocean Subtropical Gyre

Abstract The observed subtropical gyre in the North Pacific shows a shift in meridional location with depth. At shallow levels the density deviation peaks at around 15°N while at deep levels the peak is more like 30°N. It is argued here using analytical solutions to the beta-plane shallow-water equations that such a shift can be explained by the effects of oceanic dissipation processes. These solutions show that the highly damped solution is approximately proportional to Ekman pumping whereas the lightly damped case tends toward the classical Sverdrup solution. In the North Pacific, Ekman pumping peaks near 15°N while the Sverdrup solution peaks at 30°N. It is further demonstrated that 1) density deviations in the upper ocean are more highly influenced by higher order baroclinic modes than those in the deep, which are influenced by the lower modes, and 2) constant dissipation effectively acts much more strongly on the higher order baroclinic modes because of their slower speeds and smaller Rossby radii. T.
Letter: sequential therapy for Helicobacter pylori eradication in children ' updated meta‐analysis of randomized controlled trials

SIRS, Previously, we have shown in a meta-analysis that 10-day sequential therapy compared with standard triple therapy may be considered as an option for increasing the eradication rates in children with Helicobacter pylori (H. pylori) infection. Recently, one of the randomized controlled trials (RCTs) included in our meta-analysis has been retracted by the editors of the Journal of Pediatric Gastroenterology and Nutrition ‘after finding issues related to the institutional review board approval of the project’, prompting us to re-evaluate the role of sequential therapy in children with H. pylori infection. For completeness, we re-searched databases (i.e. MEDLINE, EMBASE, and the Cochrane Library) from May 2012 (last search) to 30 January 2013 for any new trials published subsequent to our meta-analysis. The methods used are discussed in full detail in the original meta-analysis. The updated meta-analysis included 9 RCTs involving 813 children aged 3–18 years compared with 10 RCTs (857 children aged 3–18 years). Of the 395 patients in the sequential therapy group, 303 (77%, 95%: CI 72–81) experienced eradication compared with 301 of the 418
Lysis of Gram-negative bacteria by host-independent ectoparasitic Bdellovibrio bacteriovorus isolates.

Surmmary Methods of isolation and nutritional requirements of Bdellovibrio bacteriovorus strains capable of growth on host-free media are described. Such strains retained their parasitic capacities for various Gram-negative bacteria after many transfers in host-free media. In parasite + host suspensions the spectrum of host specificity of various bdellovibrio strains was considerably wider than that obtained by examination for plaques on host lawns. The growth conditions therefore affect the capacity of the bdellovibrios to attach to and lyse host organisms. A proteolytic exoenzyme formed by certain bdellovibrio strains digested heat-killed, acid-treated or EDTA-treated host organisms, but did not affect intact host organisms. High phosphate concentrations inhibited exoenzyme activity. The morphological sequence of lysis induced by exoenzyme-forming parasitic bdellovibrio strains suggested that this lysis was a two-stage process: the first stage was specific attachment of bdellovibrios with damage to the cell wall of the host organisms; the second stage was non-specific digestion of cellular components by exoenzyme produced by the bdellovibrios.
1 Distributed Resource Allocation in 5 G Cellular Networks

The fifth generation (5G) cellular networks are expected to provide wide variety of high rate (i.e., 300 Mbps and 60 Mbps in downlink and uplink, respectively, in 95 percent of locations and time [1]) multimedia services. The 5G communication platform is seen as a global unified standard with seamless connectivity among existing standards, e.g., High Speed Packet Access (HSPA), Long Term Evolution-Advanced (LTE-A), and Wireless Fidelity (WiFi). Some of the emerging features and trends of 5G networks are: multi-tier dense heterogeneous networks [2], [3], device-to-device (D2D) and machine-to-machine (M2M) communications [3], [4], densification of the heterogeneous base stations (e.g., extensive use of relays and small cells) [5], cloud-based radio access network [3], integrated use of multiple radio access technologies [6], wireless network virtualization [3], massive and 3D MIMO [3], [7], millimeter wave [8], and full duplex [9] communications. Conventional 3G systems are single-tier and based on code division multiple access (CDMA) technology. In CDMA systems, all network nodes use the same frequency resource and are distinguished from each other by different pseudo-random spreading codes, which are not exactly orthogonal. Therefore the interference among the nodes is closely related to transmit power. Through efficient power control and spreading schemes [10], [11], interference in CDMA systems can be well-managed. 4G systems (such as LTE/LTEA) employ orthogonal frequency division multiplexing (OFDM) to improve the spectrum efficiency. Due to unplanned deployment of small cells, resource allocation and interference management in 4G networks is quite different to those in single-tier 3G networks. In a heterogeneous 4G network (which is mainly consists with macro and small cells), there is always a major interferer leading to higher dominant-interference-ratio compared to singletier network [12]. Therefore, advance interference management schemes such as almost blank