Miracle-dz/UniFAR-FTUs huggingface dataset:
A review of cognitive biases in youth depression: attention, interpretation and memory

ABSTRACT Depression is one of the most common mental health problems in childhood and adolescence. Although data consistently show it is associated with self-reported negative cognitive styles, less is known about the mechanisms underlying this relationship. Cognitive biases in attention, interpretation and memory represent plausible mechanisms and are known to characterise adult depression. We provide the first structured review of studies investigating the nature and causal role of cognitive biases in youth depression. Key questions are (i) do cognitive biases characterise youth depression? (ii) are cognitive biases a vulnerability factor for youth depression? and (iii) do cognitive biases play a causal role in youth depression? We find consistent evidence for positive associations between attention and interpretation biases and youth depression. Stronger biases in youth with an elevated risk of depression support cognitive-vulnerability models. Preliminary evidence from cognitive bias modification paradigms supports a causal role of attention and interpretation biases in youth depression but these paradigms require testing in clinical samples before they can be considered treatment tools. Studies of memory biases in youth samples have produced mixed findings and none have investigated the causal role of memory bias. We identify numerous areas for future research in this emerging field.
Randomised controlled trial of continuous positive airway pressure and standard oxygen therapy in acute pulmonary oedema; effects on plasma brain natriuretic peptide concentrations.

AIMS The study aim was to compare the effects of continuous positive airway pressure (CPAP) on clinical outcomes and plasma neurohormonal concentrations in patients with acute pulmonary oedema. METHODS AND RESULTS In addition to standard therapy, 58 consecutive patients were randomized to receive 60% inhaled oxygen with or without CPAP at 7.5 cmH(2)O pressure. Clinical variables, symptoms and oxygenation were monitored and plasma epinephrine, norepinephrine and brain natriuretic peptide (BNP) concentrations estimated at 0, 1, 6 and 24 h. CPAP was associated with less breathlessness at 1 h (P<0.001), no treatment failures and more rapid resolution in respiratory rate (P<0.001), heart rate (P<0.001) and acidosis (P<0.005). Length of hospital stay was similar but there was a trend for a reduction in overall hospital mortality in the CPAP group (0.10>P>0.05). Plasma BNP concentrations rose progressively (P<0.001) before falling below admission concentrations at 24 h. Plasma neurohumoral concentrations were unaffected by CPAP treatment but were elevated in patients who died or had acute myocardial infarction. CONCLUSION CPAP produces a more rapid clinical and symptomatic improvement in patients with acute pulmonary oedema, particularly within the first hour. CPAP is a useful adjunctive treatment in the early management of acute heart failure.
The contribution of extended-spectrum &bgr;-lactamases to multidrug-resistant infections in children

Purpose of review The prevalence of multidrug-resistant (MDR) infections caused by Gram-negative rods (GNRs) such as Escherichia coli and Klebsiella pneumoniae is increasing in large part because of the production of extended-spectrum &bgr;-lactamases (ESBLs) that confer resistance to third-generation cephalosporins such as ceftriaxone. This review examines the clinical implication of changes in the epidemiology, diagnostic tools, and reporting criteria for ESBL-GNRs. Recent findings Pediatric ESBL-GNR infections, once associated only with hospitals, are increasing in the community. The most common risk factor for ESBL-GNR infection is previous antibiotic use. Evidence also exists for prolonged fecal carriage after discharge from neonatal ICUs, leading to community transmission with close contact of known carriers. Controversial changes in the laboratory criteria for GNR cephalosporin resistance have also contributed to the increased numbers of reported MDR-GNR infections. Newer diagnostic tools will enable more rapid identification of MDR-GNR infections, leading to earlier implementation of appropriate therapy. Summary ESBL-GNR infections are no longer limited to ICUs and are now being identified in children presenting from the community. Appropriate antibiotic prescribing practices are critical to limit the spread of ESBL-GNRs, and pediatricians must prepare to identify and treat these challenging infections.
Extracellular matrix production by nucleus pulposus and bone marrow stem cells in response to altered oxygen and glucose microenvironments

Bone marrow (BM) stem cells may be an ideal source of cells for intervertebral disc (IVD) regeneration. However, the harsh biochemical microenvironment of the IVD may significantly influence the biological and metabolic vitality of injected stem cells and impair their repair potential. This study investigated the viability and production of key matrix proteins by nucleus pulposus (NP) and BM stem cells cultured in the typical biochemical microenvironment of the IVD consisting of altered oxygen and glucose concentrations. Culture‐expanded NP cells and BM stem cells were encapsulated in 1.5% alginate and ionically crosslinked to form cylindrical hydrogel constructs. Hydrogel constructs were maintained under different glucose concentrations (1, 5 and 25 mM) and external oxygen concentrations (5 and 20%). Cell viability was measured using the Live/Dead® assay and the production of sulphated glycosaminoglycans (sGAG), and collagen was quantified biochemically and histologically. For BM stem cells, IVD‐like micro‐environmental conditions (5 mM glucose and 5% oxygen) increased the accumulation of sGAG and collagen. In contrast, low glucose conditions (1 mM glucose) combined with 5% external oxygen concentration promoted cell death, inhibiting proliferation and the accumulation of sGAG and collagen. NP‐encapsulated alginate constructs were relatively insensitive to oxygen concentration or glucose condition in that they accumulated similar amounts of sGAG under all conditions. Under IVD‐like microenvironmental conditions, NP cells were found to have a lower glucose consumption rate compared with BM cells and may in fact be more suitable to adapt and sustain the harsh microenvironmental conditions. Considering the highly specialised microenvironment of the central NP, these results indicate that IVD‐like concentrations of low glucose and low oxygen are critical and influential for the survival and biological behaviour of stem cells. Such findings may promote and accelerate the translational research of stem cells for the treatment of IVD degeneration.
Family History and Risk of Hair Loss

Introduction: The genetic basis of androgenetic alopecia (AGA) is well accepted in the medical community and among the general population. However, rigorous studies investigating the familial basis of AGA are lacking. The purpose of the current study was to explore the relationship between family history and expression of AGA in a sample of men from the general community. Methods: Hair loss was assessed by an independent observer trained by an expert dermatologist using the Norwood/Hamilton classification scale and a 7-point global description of hair loss. Men were classified into two groups, one as having little or no hair loss and the other having hair loss. The family history of hair loss in parents and grandparents was assessed by subject self-report. Results: Adjusting for age, men whose fathers had hair loss were 2.5 times as likely to have had some level of hair loss compared to men whose fathers had no hair loss (95% CI: 1.3–4.9). Likewise, men whose fathers had hair loss were twice as likely to have hair loss than men whose fathers had no hair loss even after adjusting for age (OR = 2.1, 95% CI: 1.2–3.7 and OR = 2.5, 95% CI: 1.4–4.7 for Norwood/Hamilton and global description of hair loss assessments, respectively). Conclusion: Results suggest that the probability of male pattern hair loss is dependent on family history and age. Hair loss in a man’s father also appears to play an important role in increasing a man’s risk of hair loss, either in conjunction with a history of hair loss in the mother or hair loss in the maternal grandfather.
Sensory potentials evoked by tactile stimulation of different indentation velocities at the finger and palm

Previous studies suggest that the rate of indentation of a tactile probe determines which skin mechanoreceptors are activated. To further investigate this possibility, indentations of 300 μm at velocities of 100 (T100) and 400 μm/ms (T400) were applied to the tip (FT) and the proximal phalanx of digit III (PP) and the thenar eminence (Pm) of ten healthy volunteers, and compared with responses after electrical stimulation at the FT. Compound sensory action potentials (CSAPs) were recorded from the median nerve through needle electrodes at the wrist and elbow. The maximal sensory conduction velocities (SNCVs) between wrist and elbow were similar with electrical and T400 stimulation, but on average were 15% lower with T100 stimulation (P < 0.001). With both indentation velocities, SNCVs were similar regardless of stimulation sites. Amplitudes of tactile CSAPs with FT stimulation were 1–2 μV at T400 and 0.3–0.4 μV at T100. The CSAP areas evoked by T100 stimulation showed a reduction from fingertip to proximal finger to palm (P < 0.05–0.005), whereas those obtained with T400 stimulation showed a reduction only at the palm (P < 0.05). The results support previous studies indicating that fast indentation at 400 μm/ms activated deeply placed Pacinian corpuscles as well as superficially situated Meissner corpuscles, whereas slower indentation at 100 μm/ms activated primarily Meissner corpuscles. © 2001 John Wiley & Sons, Inc. Muscle Nerve 24: 1213–1218, 2001
Measuring nursing home resident satisfaction with food and food service: initial testing of the FoodEx-LTC.

BACKGROUND Malnutrition impacts the quality of life and general health of many older persons living in our nation's 20,000 nursing homes (1). Despite the urgency of this issue, no instrument that measures resident satisfaction with food and food service was found in an extensive literature search. The purpose of this article is to describe the development and initial testing of a resident satisfaction with food and food service questionnaire (FoodEx-LTC) in the context of the Quality Nutrition Outcomes-Long-Term Care Model. METHODS This pilot study was conducted in two phases. During phase one the instrument was developed, peer-reviewed, and pretested. Phase two further tested the instrument using a correlational design, measuring both intermediate and long-term outcomes found on the Quality Nutrition Outcomes-Long-Term Care Model. RESULTS Hypothesis testing was used to measure construct validity. 4 of 5 FoodEx-LTC domains were significantly correlated with depression, 2 of 5 with serum albumin. The FoodEx-LTC demonstrates acceptable reliability for a new instrument. The coefficient alpha scores ranged from.69-. 87 and test-retest correlations ranged from.55-. 89, dependent upon domain. CONCLUSIONS FoodEx-LTC appears to be a valid and reliable measure of resident food and food service satisfaction in nursing homes. This line of inquiry is of great importance because perceived quality of food and food service are strongly related to quality of life for residents in nursing homes, and adequate food intake is integral to maintaining weight and preventing protein-calorie malnutrition among elderly residents.
A teacher's response to ‘“Where the wild things are” – an insider's experience of the contemporary classroom’

ABSTRACT In this piece of writing, I respond to Anon's reflections on her/his experiences of being taught Drama in a British high school, recently published in this journal (see Anon. 2017. ‘“Where the wild things are” – an insider's experience of the contemporary drama classroom’, RIDE: The Journal of Applied Theatre and Performance, 22:2, 216–219). As a Drama teacher working in UK education for 13 years, I empathised with the teacher in Anon's account of the drama classroom. In order to provide a contextualisation of UK arts education that form the broader landscape of Anon's account, I reflect on the pressures of drama teaching in the contemporary classroom partly created by the UK government's marginalisation of arts subjects in schools.
Drunk and Disorganised: Relationships between Bar Characteristics and Customer Intoxication in European Drinking Environments

Preventing alcohol-related harm in drinking environments is a growing international priority. Factors relating to the physical, social and staffing environments in bars can contribute to increased alcohol consumption and harm. Understanding the relationships between such factors and intoxication in European drinking environments is critical to developing appropriate interventions. We undertook a quantitative observational study in 60 bars in four European cities, in The Netherlands, Slovenia, Spain and the UK (n = 237 observational visits). Using a structured observational schedule, researchers recorded characteristics of the bar environment and rated customer intoxication levels. All physical bar characteristics showed associations with intoxication before interactions between them were controlled for. Hierarchical modelling found significant independent associations between intoxication and use of plastic glassware, promotion of non-alcoholic drinks (often energy drinks), permissive environments, poor washroom facilities, the presence of a dance floor, customer sexual activity/competitiveness and later observational time. Findings suggest that prevention efforts should focus on raising and enforcing managerial standards in bars. While harm reduction measures such as plastic glassware are often promoted for high risk bars, such measures are inadequate to address public health concerns and insufficient to demonstrate social responsibility.
Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathway

We have selected mutations in genes encoding components of the signaling pathway for alpha interferon (IFN-alpha) by using a specially constructed cell line. The upstream region of the IFN-regulated human gene 6-16 was fused to the Escherichia coli guanine phosphoribosyltransferase (gpt) gene and transfected into hypoxanthine-guanine phosphoribosyltransferase-negative human cells. These cells express gpt only in the presence of IFN-alpha. They grow in medium containing hypoxanthine, aminopterin, and thymidine plus IFN and are killed by 6-thioguanine plus IFN. Two different types of mutants were obtained after treating the cells with mutagens. A recessive mutant, selected in 6-thioguanine plus IFN, was completely resistant to IFN-alpha but responded normally to IFN-gamma and, unexpectedly, partially to IFN-beta. A constitutive mutant, selected in hypoxanthine-aminopterin-thymidine alone, was abnormal in expressing endogenous genes in the absence of IFN. Both types revert infrequently, allowing selection for complementation of the defects by transfection.
Consensus of second-order multi-agent systems with partial state information and intermittent interaction

This paper is concerned with consensus problems of continuous-time second-order agents, where each agent can only obtain partial state information relative to its neighbors at some sampling instants. For reaching consensus on full state, a protocol is designed, and a sufficient and necessary condition for consensus, which shows the clear relationship among the interaction topology, controller gains, and the sampling period, is obtained by analyzing the stability of multi-agent systems. Simulations are performed to validate the theoretical results.
Good clinical practice in patch testing: readings beyond day 2 are necessary: a confirmatory analysis. Members of the Information Network of Departments of Dermatology.

BACKGROUND Despite general recommendations, patch test readings are still sometimes terminated at day 2. OBJECTIVE The consequences of failure to read patch tests after day 2 and the influence of exposure time to the patches is quantified. METHODS Patch test data from 9,946 patients with at least one positive reaction at day 2 or later and readings at both days 2 and 3 (from 21,062 patients tested between January 1, 1990, and December 31, 1993) collected by the Information Network of Departments of Dermatology in Germany were analyzed. RESULTS Comparing results at days 2 and 3, 34.5% of all positive reactions appeared at day 3 only, whereas 8.3% initially judged (weakly) positive were not considered allergic at day 3. Some standard allergens showed specific patterns. Additional positive reactions and an increasing percentage of diminishing reactions can be observed at day 4 (compared with day 3). CONCLUSION The importance of late reading(s) is emphasized by the proportion of potentially false judgments based on readings at day 2 only.
The expression of Ep-CAM (17-1A) in squamous cell cancers of the lung.

Immunotherapy trials using monoclonal antibodies 323/A3 and 17-1A that recognize Ep-CAM, including trials focused on cancer of the lung, currently are underway. Nevertheless, there have been few comprehensive evaluations of the expression of Ep-CAM in specific types of neoplastic processes, including cancer of the lung. The current study of 60 human subjects with squamous cell cancer (SCC) of the lung, selected at random, was undertaken (1) to examine the expression of Ep-CAM in SCC and associated uninvolved bronchial mucosa, bronchial epithelial hyperplasia, and dysplasia, and (2) to correlate the results with established prognostic indicators and survival of patients. In both the uninvolved bronchial mucosa and epithelial hyperplasia, the expression of Ep-CAM in luminal cells was significantly higher compared with its expression in the matched basal cells (P = .003, P < .0001, respectively). When Ep-CAM scores of basal and luminal cells present in uninvolved bronchial mucosa and epithelial hyperplasia were combined, we observed a statistically significant stepwise increase in Ep-CAM expression from uninvolved bronchial mucosa to epithelial hyperplasia to SCC, suggesting its involvement in malignant transformation of SCC. The expression of Ep-CAM was significantly higher in poorly to moderately differentiated SCC compared with well-differentiated SCC (P = .04). An increase in the expression of Ep-CAM with increasing size or local extent of the primary tumor approached statistical significance (P = .09). The expression of Ep-CAM increased significantly with increasing involvement of regional lymph nodes (P = .02). Similarly, the expression of Ep-CAM increased with the increasing TNM stages (P = .04). Kaplan-Meier Survival analysis using the same categorizations showed that increasing tumor size, nodal status, and stage were significantly associated with poor patient survival (P = .04, .01, .01, respectively). There was, however, no statistically significant association between patient survival and staining intensity of carcinomas for Ep-CAM. We conclude that expression of Ep-CAM increased during the progression of SCC of the lung and, therefore, may play a role in the carcinogenesis of this disease.
Comparison of missing data imputation methods for traffic flow

The complete and reliable field traffic data are vital for the planning, design and operation of urban traffic management systems. However, the problem of traffic data missing widely exists in many traffic information systems, which brings great troubles to the further utilization. Some approaches for imputing missing traffic data are needed, therefore, to minimize the effect of incomplete data on utilization. There are also problems of value missing in microarray data and several methods to estimate the missing values are proposed. These methods don't exploit any biology knowledge to estimate the missing value and they are just methods for data mining which can also be applied to the imputation of traffic flow data. In the paper, ten imputation methods for handling missing value problem of microarray data are compared with Bayesian Principle Component Analysis (BPCA) imputation method which is convinced to outperform many conventional approaches. Experiment analysis shows that LSI_gene, LSI_array, LSI_combined, LSI_adaptive, EM_gene and local least square imputation methods outperform BPCA and be good choices to deal with the problem of missing traffic data imputation.
A TEST OF THE HYPOTHESIS THAT CORRELATIONAL SELECTION GENERATES GENETIC CORRELATIONS

Theory predicts that correlational selection on two traits will cause the major axis of the bivariate G matrix to orient itself in the same direction as the correlational selection gradient. Two testable predictions follow from this: for a given pair of traits, (1) the sign of correlational selection gradient should be the same as that of the genetic correlation, and (2) the correlational selection gradient should be positively correlated with the value of the genetic correlation. We test this hypothesis with a meta‐analysis utilizing empirical estimates of correlational selection gradients and measures of the correlation between the two focal traits. Our results are consistent with both predictions and hence support the underlying hypothesis that correlational selection generates a genetic correlation between the two traits and hence orients the bivariate G matrix.
Transhumanism and the transformation of the experience and spectacle in the art of boxing

Going beyond the biological and physiological limitations imposed on us by the human body is something which the human race has strived to do throughout its history. There is something about our human nature that compels us to strive for improvement and enhancement in our physical and mental performance, and to stretch ever further the boundaries of human accomplishment. Nowhere can a stronger desire for enhanced performance be found than in the realm of competitive sport and, it is certainly arguable that, there are very few sports that can rival the competitiveness, endurance and physical exertion involved in the sport of boxing. Transhumanism is borne of this desire for continuous improvement and the refusal to resign ourselves to the restrictions placed on us by our natural biological constitution and environment, enhancing human capabilities and capacities by way of new and emergent technologies. With regard to sport, transhumanism could provide us with the ability to train longer, run, swim or cycle faster, jump higher, throw further and, in the case of boxing, punch harder. However, it is not restricted or confined to the enhancement of our physical powers, but could equally-well serve to improve our psychological capacities and alter the way in which we perceive and experience the world. In this way transhumanism could be employed to change the content of experience.
Paradoxes of High-Stakes Testing

Over the centuries and across nations, tests have been employed as bureaucratic tools for a variety of purposes. As far back as 200 BC, the Chinese used tests to help eliminate patronage and open access to the civil service. The Dead Sea scrolls describe the use of tests by the Qumran community to determine when a man was ready to become a formal member of the community. England, France, and Italy, among other nations, have used tests to ensure that students acquire certain skills and establish standards of performance. In fifteenthcentury Italy, tests were used to hold teachers accountable for student learning. Since then, policy-makers have used tests to hold students and schools accountable and allocate scarce resources.