Miracle-dz/UniFAR-FTUs huggingface dataset:
Surgery plus chemotherapy improves survival of patients with extremity soft tissue leiomyosarcoma and metastasis at presentation

Purpose: Extremity soft tissue leiomyosarcoma (LMS) with metastasis is a rare disease with a poor prognosis. The purpose of our study was to define clinical features of extremity soft tissue LMS with metastasis as well as to identify multivariable predictors of survival. Methods: During 1973-2015, 239 patients with metastatic extremity soft tissue LMS were identified from the Surveillance, Epidemiology, and End Results (SEER) program database. The prognostic analysis was performed using the Kaplan-Meier method and a Cox proportional hazards regression model. Results: This group comprised 126 females (52.7%) and 113 males (47.3%), whose ages ranged from 8 to 95 years (median 67 years). The overall survival (OS) and cancer-specific survival (CSS) rates of the entire group at 3 years were 22.6% and 23.4%, respectively. The median OS and CSS were 14.0±1.5 and 15.0±2.3 months, respectively. Multivariate analysis revealed that tumor size >10 cm, no surgery and no chemotherapy were independent risk factors of decreased OS and CSS. Radiotherapy was not significantly associated with OS or CSS. Conclusion: Extremity soft tissue LMS patients who present with metastasis at diagnosis had a poor prognosis. Patients who performed surgery for primary tumors and chemotherapy had a better chance for prolonged survival.
The phylogenetic relationships of the Elasmotherini (Rhinocerotidae, Mamm.)

A cladistic analysis of the extinct rhinoceros tribe Elasmotherini is presented, based mainly on dental morphology. The result is a new classification of Begertherium (formerly Hispanotherium) grimmi (H eissig) and Begertherium (formerly Beliajevina) tekkayai (H eissig). It is possible to recognize a Hispanotherium-clade and an Elasmotherium-clade at a suprageneric le­ vel, but to do so formally serves no useful purpose.
On error in scientific publications and its detection: the case of pharmaceutical clinical trials

The last decade has witnessed a rapid increase in the number of mistakes that accompany scientific publications. In this paper we draw attention to this phenomenon by analyzing the determinants of error in publications by focusing on clinical research. This field has become remarkably standardized in recent years facilitating the development of common reference frames against which inconsistencies can be more easily identified. At the same time, clinical research has undergone major organizational change including a rapid increase in university-industry collaborations and the globalization of patient enrolment which may hinder effective research coordination. We hypothesize that, in this context, the detection of error can be understood from coordination failure, as well as from the prestige of research. Empirically, we link detailed information from protocols, publications and published errata of 4,777 clinical trials. All errata are classified based on the number and nature of mistakes. Our findings indicate that corrections in the scientific literature depend amongst others on the expected impact of publications, academic peer-control, project size, funding sources and the geographical distance between researchers. We also observe significant differences between these factors depending on the nature of error. More specifically, the likelihood of content-related errors increase with the geographical distance, the project size and commenting by peers, whereas the likelihood of deviations from institutional publishing norms as set within the academic community increase with the organization of the writing process and when the project is industry-funded. A discussion on the implications for the governance of scientific knowledge production
Phase 1 study evaluating the safety, tolerability, pharmacokinetics (PK), and efficacy of AMG 510, a novel small molecule KRASG12C inhibitor, in advanced solid tumors.

3003 Background: The KRASG12C mutation is found in approximately 13% of lung adenocarcinomas and 1–3% of other solid tumors, but there is no approved therapy that targets this mutation. AMG 510 is a novel small molecule that specifically and irreversibly inhibits KRASG12C by locking it in an inactive GDP-bound state. Methods: This phase 1, first-in-human, open-label, multicenter study (NCT03600883) is evaluating the safety, tolerability, PK, and efficacy of AMG 510 in adult patients (pts) with locally-advanced or metastatic KRASG12C mutant solid tumors. The primary endpoint is safety; key secondary endpoints include PK, ORR (assessed every 6 weeks [wks]), DOR, and PFS. Key inclusion criteria: KRASG12C mutation identified through DNA sequencing, measurable or evaluable disease, ECOG PS ≤2, life expectancy >3 months (mo). Key exclusion criteria: active brain metastases, myocardial infarction within 6 mo. A dose exploration will determine the maximum tolerated dose (MTD) or recommended phase 2 dose (RP2D). A dose expansion will enroll pts with NSCLC, CRC, and other advanced solid tumors carrying the KRASG12C mutation. AMG 510 will be given PO until disease progression, intolerance, or withdrawal of consent. Results: 22 pts (8 men, 14 women; median age 55.5 y) were enrolled in the first 3 dose cohorts. Tumor types: 6 NSCLC, 15 CRC, 1 other. Most pts (n=17) had ≥3 prior lines of treatment (tx). Median tx duration was 28 d (range: 8–134). 5 pts reported 10 treatment-related AEs (grade 1, n=9; grade 2, n=1); there were no DLTs. Tumor response was evaluated in 9 pts (4 with ≥2 assessments); 13 pts have not reached their first assessment.1 pt had a PR (NSCLC at wks 6 and 12, tx ongoing), 6 pts had SD (4 CRC and 2 NSCLC; median tx duration 9.7 wks [range: 6.3–19.1], tx ongoing), 2 pts had PD. 20 pts are continuing to receive AMG 510. A second PR (NSCLC at wk 6, tx ongoing) was reported after data cutoff. Conclusions: AMG 510 has been well tolerated at the dose levels tested and has shown antitumor activity when administered as monotherapy to patients with advanced KRAS G12C mutant solid tumors. MTD has not been determined, and enrollment into the dose exploration is ongoing. Clinical trial information: NCT03600883.
Susceptibility of selected apple cultivars to the Mediterranean fruit fly

Ceratitis capitata (Wiedemann), the Mediterranean fruit fly, is one of the key pest species affecting deciduous fruit orchards along the Mediterranean coasts. Because of global warming, C. capitata is gradually spreading north and is becoming a major pest of apples. Determining the susceptibility of the main apple varieties grown in the region will serve as a cornerstone to the management of this pest. In this study, we show the results of a field and laboratory no‐choice test conducted to determine the Medfly preferences on different apple cultivars. The seven main varieties of apples (Gala, Red Delicious, Golden Delicious, Granny Smith, Kanzi, Morgen Dallago and Fuji) were tested. The results demonstrate that C. capitata lays eggs on all apple cultivars in both field and laboratory conditions. The Granny Smith, Red Delicious and Morgen Dallago varieties showed the lowest susceptibility in laboratory conditions, (0.75, 1.55, 2 oviposition punctures/fruit, respectively), with significant differences in oviposition compared to the Golden Delicious, Kanzi and Fuji (3.27, 3.31, 3.1 oviposition punctures/fruit, respectively) varieties, which were shown to be the most susceptible to Medfly attack in laboratory conditions. On the other hand, only slight and not statistically significant differences emerged from the field trials. In relation to the physico‐chemical characteristics, the apple cultivars showing the lowest susceptibility (Granny Smith, Red Delicious and Morgen Dallago) had harder peels and pulps and lower sugar contents than the most susceptible cultivars (Golden Delicious, Fuji and Kanzi). These results were also confirmed through evaluation of larval development on different varieties. In fact, Granny Smith, Red Delicious and Morgen Dallago were the three varieties that did not allow adequate larval and adult development and reduced the possibility of the emergence of a new generation.
Systematic Analysis of Efficiency and Safety of Dexamethasone and Cimetidine in the Treatment of Gastroenteritis

The purpose of this study is to determine the efficiancy and safety of two drugs in the treatment of gastroenteritis by META analysis, and to establish a preliminary evaluation system. PubMed (1966-2018.1), CochraneLibrary (1996-2018.1), Embase (1974-2018.1), CNKI (1994-2018.1), VIP (1989-2018.1) and CBM (1978-2018.1). Exclusion criteria and quality was evaluated and data were extracted. Meta analysis was performed using RevMan 5.0 software. A total of 16 RCTs were enrolled. The quality of the study was moderate. A total of 1333 patients with ulcerative colitis were enrolled. Meta-analysis showed that in the total rate, dexamethasone was superior to cimetidine in the treatment of ulcerative colitis. There were 12 RCTs reported adverse reactions, and dexamethasone had fewer adverse reactions. META analysis showed that both efficacy and safety of dexamethasone were better.
Impact of neuropsychiatric symptoms on caregiver burden in patients with Alzheimer’s disease

SUMMARY Neuropsychiatric symptoms (NPS) are very common amongst patients with Alzheimer’s disease and contribute significantly to caregiver burden. Different NPS may contribute differently to caregiver burden. This has important implications for targeting treatment. Medline was searched using the keywords ‘caregiver burden’, ‘BPSD’, ‘behavioral problems’, ‘Alzheimer’s disease’, ‘dementia’ and ‘dementia of the Alzheimer type’. After an extensive search, 14 papers were identified. Caregiver burden and related quality-of-life measures were significantly associated with NPS in all studies. When compared with other factors, NPS had a stronger association than demographic and cognitive factors and a similar association with functional impairment. Psychotic symptoms were consistently associated with increased caregiver burden compared with other NPS. Pharmacological and nonpharmacological interventions should focus on addressing the NPS that are most associated with increased caregiver burden.
Motor Learning and Performance: From Principles to Application

Chapter 1. Evolution of a Field of Study Chapter 3. Human Information Processing Part II: Motor Control Chapter 5. Sensory Contributions to Motor Control Chapter 7. Principles of Speed and Accuracy Chapter 9. Individual Differences and Capabilities Part III: Motor Learning Chapter 11. Conditions of Practice Chapter 13. The Learning Process Chapter 14. Retention and Transfer.
Time Sharing on Stage: Drama Translation in Theatre and Society

Intercultural theatre: at the crossroads of cultures the text-centred theatre tradition the exchange of texts. Theorizing theatre translation: meaning production the theatrical system drama and theatre theatre texts on the page speakability, playability, performability. The time-sharing of theatre texts: translation as a form of egotism productive reception I - compatibility, II - integration, III - alterity reverence subversion. Translator in the attic: who is speaking? and why is s/he speaking thus? authorship and copyright integrity and la perruque a way forward.
Is there any relationship between PSA and increased peripheral CD4+CD25highFOX3+ Treg in prostate cancer patients?

Introduction: The aims of this study were fi rst, to determine whether peripheral levels of CD4+CD25highFoxp3+ regulatory T cells (Treg) are elevated in Prostate Cancer (PCa) patients, and second, to determine the directcorrelation between peripheral Treg and total serum Prostate Specifi c Antigen (PSA) levels in these patients.Methods: Peripheral Blood Mononuclear Cells from 56 subjects undergoing diagnostic prostate biopsies (PSA ≥ 2.5 ng/ml) were analyzed for Treg numbers. The association between the peripheral Treg and serum PSA values was fi rst determined in the entire population, including people with no prostate pathology and PCa and Benign Prostate Hyperplasia (BPH) patients, and second, in nine PCa patients before and after curative prostatectomy.Results: This project was performed in Akdeniz University immunology laboratory and urology out patient clinic from 2008 to 2010. Peripheral Treg frequencies were signifi cantly increased in PCa patients (n = 19, 3.23 ± 1.59) compared with BPH patients (n = 27, 1.66 ± 0.80) and healthy subjects (n = 10, 1.08 ± 0.43) (p < 0.01). The percentage of Treg in BPH patients was also signifi cantly higher than that of healthy subjects (p < 0.01). Importantly, the increase in BPH and PCa patients paralleled the elevation in total serum PSA levels, demonstrating a strong positive correlation (r = 0.75; p < 0.01). Conclusion: These results demonstrate that peripheral Treg densities are correlated with PSA in BPH and PCa patients, suggesting that PSA may have a role in Treg induction and/or maintenance in Treg in these people.
Experience- and Sex-Dependent Intrinsic Plasticity in the Zebra Finch Auditory Cortex during Song Memorization

For vocal communicators like humans and songbirds, survival and reproduction depend on highly developed auditory processing systems that can detect and differentiate nuanced differences in vocalizations, even amid noisy environments. Early auditory experience is critical to the development of these systems. In zebra finches and other songbirds, there is a sensitive period when young birds memorize a song that will serve as a model for their own vocal production. For vocal communicators like humans and songbirds, survival and reproduction depend on highly developed auditory processing systems that can detect and differentiate nuanced differences in vocalizations, even amid noisy environments. Early auditory experience is critical to the development of these systems. In zebra finches and other songbirds, there is a sensitive period when young birds memorize a song that will serve as a model for their own vocal production. In addition to learning a specific tutor's song, the auditory system may also undergo critical developmental processes that support auditory perception of vocalizations more generally. Here, we investigate changes in intrinsic spiking dynamics among neurons in the caudal mesopallium, a cortical-level auditory area implicated in discriminating and learning species-specific vocalizations. A subset of neurons in this area only fire transiently at the onset of current injections (i.e., phasic firing), a dynamical property that can enhance the reliability and selectivity of neural responses to complex acoustic stimuli. At the beginning of the sensitive period, just after zebra finches have fledged from the nest, there is an increase in the proportion of caudal mesopallium neurons with phasic excitability, and in the proportion of neurons expressing Kv1.1, a low-threshold channel that facilitates phasic firing. This plasticity requires exposure to a complex, noisy environment and is greater in males, the only sex that sings in this species. This shift to more phasic dynamics is therefore an experience-dependent adaptation that could facilitate auditory processing in noisy, acoustically complex conditions during a key stage of vocal development. SIGNIFICANCE STATEMENT Auditory experience early in life shapes how humans and songbirds perceive the vocal communication sounds produced by their species. However, the changes that occur in the brain as this learning takes place are poorly understood. In this study, we show that in young zebra finches that are just beginning to learn the structure of their species' song, neurons in a key cortical area adapt their intrinsic firing patterns in response to the acoustic environment. In the complex, cocktail-party-like environment of a colony, more neurons adopt transient firing dynamics, which can facilitate neural coding of songs amid such challenging conditions.
Fundamentals of Radar Signal Processing

This detailed guide clearly and concisely presents radar digital signal processing for both practicing engineers and engineering students. This revised edition of Fundamentals of Radar Signal Processing provides in-depth coverage of radar digital signal processing (DSP) fundamentals and applications. It has been updated to include coverage of measurement accuracy and target tracking. Additionally, to make it more useful as a teaching tool, it now includes end-of-chapter problems and a solutions manual. New to this Edition: New chapter on Measurement Accuracy and Target Tracking Two new appendices--Important Digital Signal Processing Facts; Important Probability Density Function and Their Relationships Addition of 20 to 30 problems to ends of chapters Solutions manual
ANALYSIS OF HOMA-IR, FOLLICLE SIZE, AND ESTRADIOL AFTER COMBINATION THERAPY OF METFORMIN AND CLOMIPHENE CITRATE IN POLYCYSTIC OVARY SYNDROME’S PATIENT

PCOS is an ovarian dysfunction syndrome which characterized by the present of unovulation, hyperandrogenism, and polycystic ovarian morphology. The main cause of PCOS is still unclear, but many studies report that genetic factor have a great role. There are also two big concept in PCOS, hyperandrogenism and insulin resistance. Previous research by Ayaz et al (2013) has shown that metformin was given if there has been a resistance of clomiphene citrate. This study was designed to provide metformin and clomiphene citrate combination from the early administration to determine the effectiveness of the combination therapy. The objective of this study is to analyze HOMA-IR value, follicle size, and estradiol concentration after metformin and clomiphene citrate treatment in PCOS patient. Design of this study was an observational longitudinal prospective method. There was only a group with a total sample size 19 women of productive age (18-40 years) diagnosed with PCOS. The pre and post combination therapy was observed for ten weeks. Metformin 500 mg three times daily for ten weeks and clomiphene citrate 100 mg in 3rd day until 7th day of menstruation for two cycles were given to the subjects. The result showed that HOMA-IR value decrease after 10 weeks in which value before therapy was 4.9 ± 2.4 and after therapy 3.7 ± 2.2 with the achievement 21.1% HOMA-IR under 2.5. Estradiol concentration after therapy also decreased from 64.8 ± 24.7 pg/ml to 37.9 ± 17.9 pg/ml in ten weeks this concentration remained the range of the follicular phase estradiol levels. On the other hand, follicle size increased from 4.7 ± 0.6 mm to 10.7 ± 2.2 mm after combination therapy of metformin and clomiphene citrate with the occurrence of ovulation 31.6% but none of the samples were successfully pregnant. It is concluded that women with PCOS, declined HOMA-IR, estradiol, and increased follicle size was associated with a good response to combination therapy of metformin and clomiphene citrate.
The female nude

List of Plates Introduction Part One: Theorizing the Female Nude 1. Framing the Female Body 2. A Discourse on the Naked and the Nude 3. A Study of Ideal Art 4. Aesthetics and the Female Nude 5. Obscenity and the Sublime Part Two: Redrawing the Lines 1. 'The Damaged Venus' 2. The Framework of Tradition 3. The Lessons of the Life Class 4. Art Criticism and Sexual Metaphor 5. Breaking Open the Boundaries 6. Redrawing the Lines Part Three: Cultural Distinctions 1. Sacred Frontiers 2. Pure and Motivated Pleasure 3. Policing the Boundaries 4. Displaying the Female Body 5. Erotic Art: A Frame for Desire List of Works Cited Index
Demographic, socioeconomic, dietary and physical activity determinants of obesity in a large nationally representative sample of the Lebanese adult population.

Introduction: The prevalence of obesity within countries varies by gender, age, socioeconomic status, and culture. These determinants appear to predict obesity differently in different countries. The objective of this study was to estimate the impact of these determinants on obesity in a representative sample of the Lebanese adult population. Methods: A cross-sectional survey of 2697 adults aged ≥ 20 years, excluding pregnant and lactating women, was conducted in 2008. Households were selected randomly from all Governates of Lebanon based on a stratified cluster sampling. One randomly-sampled adult was interviewed in each visited household; demographic, socioeconomic and anthropometric data were measured. Dietary intake was obtained using a 24-hour recall instrument. The prevalence of obesity in 2008 was estimated. Logistic regressions analysis was carried out to assess the relationship between energy intake and obesity as well as adjusted relevant variables, excluding data from participants who reported implausible energy intakes. Results: Currently, approximately one in four Lebanese adults is obese. While men and women showed overall similar prevalence rates of obesity, gender disparities were noted across obesity classes and age groups. In males, the odds of being obese increased among those married, employed, and owning increased household assets; the opposite was the case for women. Obesity in women decreased with increasing household wealth. In women also, there was a positive association between obesity and energy intake, and a negative association between obesity and physical activity. Obese adults reported consuming a higher percentage of their energy intake from fat, and a lower intake from cereals, compared with their non-obese counterparts. Conclusion: The prevalence of obesity among Lebanese adults is on the rise, with significant demographic and socioeconomic differentials. High energy consumption and inactivity of Lebanese adults, as well as several complex socioeconomic and cultural elements, are contributing factors to the estimated high rates of obesity.
Age and the rate of foreign language learning

Contents Introduction - Carmen Munoz (Universitat de Barcelona) 1. The Effects of Age on Foreign Language Learning: the BAF Project - Carmen Munoz 2. The Development of English (FL) Perception and Production Skills: Starting Age and Exposure Effects - Natalia Fullana 3. Age Effects on Oral Fluency Development - Joan Carles Mora (Universitat de Barcelona) 4. Age and Vocabulary Acquisition in EFL - Immaculada Miralpeix (Universitat de Barcelona) 5. Accuracy Orders, Rate of Learning and Age in Morphological Acquisition - Carmen Munoz 6. Rate and Route of Acquisition in EFL Narrative Development at Different - Ages Esther Alvarez (Universitat de Barcelona) 7. Age and IL Development in Writing - Maria Rosa Torras, Teresa Naves, Maria Luz Celaya and Carmen Perez-Vidal (Universitat de Barcelona) 8. Age, Proficiency Level and Interactional Skills: Evidence from Breakdowns in Production - Gisela Granena 9. Reported Strategy Use and Age - Elsa Tragant (Universitat de Barcelona) and Mia Victori (Universitat Autonoma de Barcelona) 10. Language Learning Motivation and Age - Elsa Tragant (Universitat de Bercelona)General AppendicesIndex