Miracle-dz/UniFAR-FTUs huggingface dataset:
Prognostic nomogram for hepatocellular carcinoma in adolescent and young adult patients after hepatectomy

Background Hepatocellular carcinoma (HCC) was rarely discussed in adolescent and young adult (AYA) patients. This study aimed to discuss the character of AYA HCC patients and establish an effective prognostic nomogram for patients after hepatectomy. Results For all of the patients, the median OS was 57 months with 5-year OS rate 60.4%, and DFS was 48 months with 5-year DFS rate 51.4%. The tumor size, vascular invasion status and the pathological differentiation were the independent predictors for both OS and DFS. Except for that, gender, Neutrophil-lymphocyte ratio, HbeAg, and α-Fetoprotein were the predictors for OS. The c-index for OS prognostic nomogram was 0.75 (95% CI, 0.71 to 0.79), and c-index was 0.70 (95% CI, 0.66 to 0.74) for DFS prognostic nomogram, which was better than American Joint Commission on Cancer 2002 and 2010, Okuda staging system, the Japanese Integrated Staging system, and Tokyo staging system. Materials And Methods This study was based on 423 AYA HCC patients (younger than 40 years old) undergoing hepatectomy in West China Hospital between 2008 to 2014. Based on the multivariate risk factors, the nomogram was constructed for predict the possibility for overall survival (OS) and disease-free survival (DFS) rate. Harrel’s concordance index (c-index) was used to compare the predictive accuracy and discriminative ability between the nomogram and eight contemporary staging systems. Conclusions Our prognostic nomogram could accurately and preciously provide individual prediction for AYA HCC patients in OS and DFS after hepatectomy.
Comparing Performance During Morning vs. Afternoon Training Sessions in Intercollegiate Basketball Players

Abstract Heishman, AD, Curtis, MA, Saliba, EN, Hornett, RJ, Malin, SK, and Weltman, AL. Comparing performance during morning vs. afternoon training sessions in intercollegiate basketball players. J Strength Cond Res 31(6): 1557–1562, 2017—Time of day is a key factor that influences the optimization of athletic performance. Intercollegiate coaches oftentimes hold early morning strength training sessions for a variety of factors including convenience. However, few studies have specifically investigated the effect of early morning vs. late afternoon strength training on performance indices of fatigue. This is athletically important because circadian and/or ultradian rhythms and alterations in sleep patterns can affect training ability. Therefore, the purpose of the present study was to examine the effects of morning vs. afternoon strength training on an acute performance index of fatigue (countermovement jump height, CMJ), player readiness (Omegawave), and self-reported sleep quantity. We hypothesized that afternoon training sessions would be associated with increased levels of performance, readiness, and self-reported sleep. A retrospective analysis was performed on data collected over the course of the preseason on 10 elite National Collegiate Athletic Association Division 1 male basketball players. All basketball-related activities were performed in the afternoon with strength and conditioning activities performed either in the morning or in the afternoon. The average values for CMJ, power output (Power), self-reported sleep quantity (sleep), and player readiness were examined. When player load and duration were matched, CMJ (58.8 ± 1.3 vs. 61.9 ± 1.6 cm, p = 0.009), Power (6,378.0 ± 131.2 vs. 6,622.1 ± 172.0 W, p = 0.009), and self-reported sleep duration (6.6 ± 0.4 vs. 7.4 ± 0.25 p = 0.016) were significantly higher with afternoon strength and conditioning training, with no differences observed in player readiness values. We conclude that performance is suppressed with morning training and is associated with a decrease in self-reported quantity of sleep.
Prediction of Prolonged ICU Stay in Cardiac Surgery Patients as a Useful Method to Identify Nutrition Risk in Cardiac Surgery Patients: A Post Hoc Analysis of a Prospective Observational Study

Abstract Background Cardiovascular surgery patients with a prolonged intensive care unit (ICU) stay may benefit most from early nutrition support. Using established scoring systems for nutrition assessment and operative risk stratification, we aimed to develop a model to predict a prolonged ICU stay ≥5 days in order to identify patients who will benefit from early nutrition interventions. Methods This is a retrospective analysis of a prospective observational study of patients undergoing elective valvular, coronary artery bypass grafting, or combined cardiac surgery. The nutrition risk was assessed by well‐established screening tools. Patients’ preoperative EuroSCORE (European System for Cardiac Operative Risk Evaluation), primary disease, and intraoperative cardiopulmonary bypass (CPB) time were included as independent variables in a multivariate logistic regression analysis to predict a prolonged ICU stay (>4 days). Results The number of cardiac surgery patients included was 1193. Multivariate analysis revealed that for prediction of ICU stay >4 days, both Nutritional Risk Screening 2002 (area under the curve (AUC): 0.716, P = . 020) and Mini Nutritional Assessment (MNA) score (AUC: 0.715, P = .037) were significant, whereas for prediction of ICU stay >5 days, only the MNA score showed significant results (AUC: 0.762, P = .011). Conclusion Present data provide first evidence about the combined use of EuroSCORE, primary disease, CPB time, and nutrition risk screening tools for prediction of prolonged ICU stay in cardiac surgery patients. If prospectively evaluated in adequately designed studies, this model may help to identify patients with prolonged ICU stay to initiate early postoperative nutrition therapy and thus, facilitate an enhanced recovery.
Concurrent developmental course of sleep problems and emotional/behavioral problems in childhood and adolescence as reflected by the dysregulation profile

OBJECTIVES Longitudinal data on the course and relationship of concurrent psychopathology in youth are scarce but are of need for better practical patient care and prevention. This study explores the course of (and relationships over time) between sleep problems and concurrent dimensional difficulties relating to anxiety/depression, attention deficiency, and aggressive behaviors in childhood and adolescence. The latter three may jointly form a broad syndrome, the dysregulation profile. METHODS Young people from the Raine Study, a large community cohort sample (N = 1625) were followed from age 5 to 17 years. Developmental courses of sleep problems and its concurrent regulatory difficulties were estimated separately and jointly. RESULTS The majority of adolescents reported low levels of problems and which appeared to be stable over time, while a small group (rates between 7.8% and 10.1%) reported enduring problematic developmental courses. Sleep problems and regulatory difficulties shared a strong association in their development over time (individual's probabilities of having the same courses, i.e. low-low and high-high, were between 89.8% and 92.3%). Furthermore, having persistent sleep problems over time was associated with an increased risk of having regulatory difficulties by approximately 10 times, and vice versa. CONCLUSION Findings from this study provide empirical evidence for a strong mutual association in the development of sleep problems and difficulties of dysregulation with emotion, cognition, and aggression. It may be suggested that a positive screening of one such psychopathological dimension should lead to a careful assessment, not only to reduce the problem in question but also to prevent the youth from further problems.
Changes in programmed death-ligand 1 expression during cisplatin treatment in patients with head and neck squamous cell carcinoma

Programmed death-ligand 1 (PD-L1) expression is regarded as a predictive marker for anti-PD-1/PD-L1 therapy. The purpose of study was to explore the changes in PD-L1 expression in head and neck squamous cell carcinoma (HNSCC) during treatment. Paired HNSCC tissues prior to and after cisplatin-based treatment were evaluated to determine PD-L1 protein expression by immunohistochemistry. Among the 35 HNSCC patient samples, PD-L1 expression status changed after treatment in 37.1% (13/35) of samples. Among the 13 patients whose baseline PD-L1 was negative, PD-L1 expression was increased in 9 cases (69.2%) and remained negative in 4 cases (30.8%, P = 0.003). Patients exposed to cisplatin generally showed PD-L1 up-regulation (83.3%, P = 0.037) compared to those not exposed to cisplatin (57.1%, P = 0.072). To validate these findings in vitro, changes in PD-L1 expression in HNSCC cell lines (Detroit-562, PCI-13, SNU-1041, SNU-1066, SNU-1076, and FaDu) were analyzed by western blotting and flow cytometry after treatment with cisplatin and interferon-gamma. In HNSCC cell lines, PD-L1 expression was significantly up-regulated after cisplatin, along with phosphor-MAPK/ERK kinase up-regulation. In conclusion, PD-L1 expression in HNSCC may be altered during cisplatin treatment, activating the MAPK/ERK kinase pathway.
Spin transport in a Mott insulator of ultracold fermions

Simulating transport with cold atoms Much can be learned about the nature of a solid from how charge and spin propagate through it. Transport experiments can also be performed in quantum simulators such as cold atom systems, in which individual atoms can be imaged using quantum microscopes. Now, two groups have investigated transport in the so-called Fermi-Hubbard model using a two-dimensional optical lattice filled with one fermionic atom per site (see the Perspective by Brantut). Moving away from half-filling to enable charge transport, Brown et al. found that the resistivity had a linear temperature dependence, not unlike that seen in the strange metal phase of cuprate superconductors. In a complementary study on spin transport, Nichols et al. observed spin diffusion driven by superexchange coupling. Science, this issue p. 379, p. 383; see also p. 344 Atomic transport in a 2D optical lattice is investigated in the strongly interacting regime at or near half-filling. Strongly correlated materials are expected to feature unconventional transport properties, such that charge, spin, and heat conduction are potentially independent probes of the dynamics. In contrast to charge transport, the measurement of spin transport in such materials is highly challenging. We observed spin conduction and diffusion in a system of ultracold fermionic atoms that realizes the half-filled Fermi-Hubbard model. For strong interactions, spin diffusion is driven by super-exchange and doublon-hole–assisted tunneling, and strongly violates the quantum limit of charge diffusion. The technique developed in this work can be extended to finite doping, which can shed light on the complex interplay between spin and charge in the Hubbard model.
Decreased Bioelectrical Impedance Phase Angle in Hospitalized Children and Adolescents with Newly Diagnosed Type 1 Diabetes: A Case-Control Study

The aim of this study was to assess the body composition and nutritional status of hospitalized pediatric patients with newly diagnosed type 1 diabetes by using bioelectrical impedance analysis (BIA) with phase angle (PA) calculation. PA is considered to be a useful and very sensitive indicator of the nutritional and functional status, and it has not yet been evaluated in such a population. Sixty-three pediatric patients aged 4 to 18 years, with newly diagnosed type 1 diabetes, were included in the study. The control group consisted of 63 healthy children and adolescents strictly matched by gender and age in a 1:1 case: control manner. In both groups, BIA with PA calculation was performed. Diabetic patients, in comparison to control subjects, had a highly significantly lower PA of 4.85 ± 0.86 vs. 5.62 ± 0.81, p < 0.001. They also demonstrated a lower percentage of body cell mass (BCM%), 46.89 ± 5.67% vs. 51.40 ± 4.19%, p < 0.001; a lower body cell mass index (BCMI), 6.57 ± 1.80% vs. 7.37 ± 1.72%, p = 0.004; and a lower percentage of muscle mass (MM%), 44.61 ± 6.58% vs. 49.40 ± 7.59%, p < 0.001, compared to non-diabetic controls. The significantly lower PA value in diabetic patients indicate their worse nutritional and functional status compared to healthy subjects. To assess the predictive and prognostic value of this finding in this population, further prospective studies involving larger sample of patients are required.
Competing subsistence needs are associated with retention in care and detectable viral load among people living with HIV

ABSTRACT Competing priorities between subsistence needs and health care may interfere with HIV health. Longitudinal data from the Los Angeles-based HIV Outreach Initiative were analyzed to examine the association between competing subsistence needs and indicators of poor retention-in-care among hard-to-reach people with HIV. Sacrificing basic needs for health care in the previous six months was associated with a 1.55 times greater incidence of missed appointments (95% CI 1.17, 2.05), 2.32 times greater incidence of emergency department visits (95% CI 1.39, 3.87), 3.66 times greater incidence of not receiving ART if CD4 < 350 (95% CI 1.60, 8.37), and 1.35 times greater incidence of detectable viral load (95% CI 1.07, 1.70) (all p < 0.01). Among hard-to-reach PLHIV, sacrificing basic needs for health care delineates a population with exceptional vulnerability to poor outcomes along the HIV treatment cascade. Efforts to identify and reduce competing needs for this population are crucial to HIV health outcomes.
Public Health Response to an Avian Influenza A(H7N8) Virus Outbreak in Commercial Turkey Flocks — Indiana, 2016

In January 2016, highly pathogenic avian influenza (HPAI) A(H7N8) virus and low pathogenicity avian influenza (LPAI) A(H7N8) virus were detected in commercial turkey flocks in Dubois County, Indiana. The Indiana State Department of Health (ISDH) and the Dubois County Health Department (DCHD) coordinated the public health response to this outbreak, which was the first detection of HPAI A(H7N8) in any species (1). This response was the first to fully implement unpublished public health monitoring procedures for HPAI responders that were developed by the U.S. Department of Agriculture (USDA) and CDC in 2015 (Sonja Olsen, CDC, personal communication, October 2017). No cases of zoonotic avian influenza infection in humans were detected during the outbreak.
Analisis terhadap Disposisi Berpikir Kreatif Siswa pada Pembelajaran Matematika

This article was a qualitative research type grounded theory. The purpose of this study is to analyze the creative thinking disposition through junior high school students in order to understand students’ disposition on creative thinking deeply. This study belongs to postpositivism paradigm research. According to ontological side, the reality about students’ creative thinking disposition is actually appeared on students but not or have not been understood before, it just predictable. Otherwise, according to epistemologycal side, the prediction about creative thinking disposition is needed to be more understood. That’s way qualitative research is needed to overcome students’ negative creative thinking disposition. Researcher as the instrument analyzes students’ creative thinking disposition wisely with using triangulation of the data. This study was implemented in one of the junior high school with 25 students as the subject. Based on the analysis of the data, the finding is obtained in this study are: (1) the has complete facilities with fresh air and a clean environment, (2) mathematics studying and learning process is very optimal and conducive so that it can give a positive attitude in students’ creative thinking disposition, (3) based on the result of questionnaire data, there are 20 students (80%) have a positive attitude in creative thinking disposition, although there are 5 students (20%) have a negative attitude in creative thinking disposition. We can conclude that most of the students have a positive attitude in creative thinking disposition.
Coherent Electron Trajectory Control in Graphene.

We investigate coherent electron dynamics in graphene, interacting with the electric field waveform of two orthogonally polarized, few-cycle laser pulses. Recently, we demonstrated that linearly polarized driving pulses lead to sub-optical-cycle Landau-Zener quantum path interference by virtue of the combination of intraband motion and interband transition [Higuchi et al., Nature 550, 224 (2017)NATUAS0028-083610.1038/nature23900]. Here we introduce a pulsed control laser beam, orthogonally polarized to the driving pulses, and observe the ensuing electron dynamics. The relative delay between the two pulses is a tuning parameter to control the electron trajectory, now in a complex fashion exploring the full two-dimensional reciprocal space in graphene. Depending on the relative phase, the electron trajectory in the reciprocal space can, e.g., be deformed to suppress the quantum path interference resulting from the driving laser pulse. Intriguingly, this strong-field-based complex matter wave manipulation in a two-dimensional conductor is driven by a high repetition rate laser oscillator, rendering unnecessary complex and expensive amplified laser systems.
A Case-Cohort Study of Cadmium Body Burden and Gestational Diabetes Mellitus in American Women

Background Environmental cadmium (Cd) exposure is associated with type 2 diabetes. However, the association of Cd and gestational diabetes mellitus (GDM) is unknown. Objectives We examined the association between body burden of Cd and GDM risk. Methods We used 140 GDM cases and 481 randomly selected noncase subcohort members from the Omega Study to conduct a case-cohort study. Creatinine (Cr)–corrected Cd in early pregnancy urine (U-Cd) was measured by inductively coupled plasma mass spectrometry. Tertiles (< 0.29; 0.29–0.42; ≥ 0.43 μg/g Cr) were defined using the subcohort’s U-Cd distribution. GDM was diagnosed using the 2004 American Diabetes Association guidelines. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression. Results GDM cases had higher geometric mean U-Cd (0.39 μg/g Cr; 95% CI: 0.37, 0.41) than noncases (0.31 μg/g Cr; 95% CI: 0.29, 0.33). Odds ratios for GDM increased with increasing U-Cd tertile (OR = 1.64; 95% CI: 0.88, 3.05 for middle vs. low tertile; OR = 2.07; 95% CI: 1.15, 3.73 for high vs. low tertile; p-trend = 0.015). Overweight/obesity (body mass index ≥ 25 kg/m2) did not modify the association between U-Cd and GDM (p = 0.26). Conclusions Our findings suggest that body burden of Cd increases risk of GDM in a dose-dependent manner. Improved understanding of environmental factors influencing GDM may facilitate early identification of women at high risk of GDM. Citation Romano ME, Enquobahrie DA, Simpson CD, Checkoway H, Williams MA. 2015. A case-cohort study of cadmium body burden and gestational diabetes mellitus in American women. Environ Health Perspect 123:993–998; http://dx.doi. org/10.1289/ehp.1408282
How Socio-Demographic Factors of Teachers’ Influence Methods of Communicating Responsible Sexual Behaviour to Students in Schools

This paper examines the ‘HowSocio-Demographic factors of Teachers influence methods of communicating Responsible Sexual Behavior to students in schools’. The paper is based on a survey study that was carried out by the researcher to establish methods used by Christian Religious Education Teachers to Communicate Responsible Sexual Behavior to students in Secondary schools in Kenya. The researcher had generally observed that despite the fact that Kenya Institute of Education had infused HIV/AIDS education program in the school curriculum, high dropout rate of girls due to pregnancies was still reported in schools as per Daily Nation (2012, October 13). This meant that majority of learners in schools were engaging in sex activities thus increasing their risk of contracting HIV and AIDS. Reducing the rate of infection among the youth through behavior change methodologies would lead to substantial slow-down of the epidemic even among married couple in the next decade. The purpose of this study was to assess how the socio-demographic factors of teachers influence methods of communicating responsible sexual behavior to students in schools. The main objective of the study was to find out whether the age, sex, culture and religious background of respondents and teacher preparedness in terms of training affected methods of communicating responsible sexual behavior to students in schools. The study was conducted in selected secondary schools within Eldoret Municipality, Rift Valley Province, Kenya. The theoretical framework of the study was influenced by the Principles of participatory communication methodologies, Frere (1970). The study adopted a pragmatic philosophical world view, which opens the door to multiple methods. The study adopted mixed method approach that combines or associates both qualitative and quantitative forms. A descriptive survey research design was adopted for the study. Simple random, purposive and stratified sampling techniques were used to select the schools, students, and Christian religious education teachers who participated in the study. Primary data was collected using questionnaires and an observation checklist. Descriptive and inferential statistics were used to analyze the data. Inferential statistics was used to test the effect and influence of independent variable on the dependent variables.
Real-time Closed Loop Neural Decoding on a Neuromorphic chip

This paper presents for the first time a real-time closed loop neuromorphic decoder chip-driven intra-cortical brain machine interface (iBMI) in a non-human primate (NHP) based experimental setup. Decoded results show trial success rates and mean times to target comparable to those obtained by hand-controlled joystick. Neural control trial success rates of ≈ 96% of those obtained by hand-controlled joystick have been demonstrated. Also, neural control has shown mean target reach speeds of ≈ 85% of those obtained by hand-controlled joystick. These results pave the way for fast and accurate, fully implantable neuromorphic neural decoders in iBMIs.
Effect of dietary additives on intestinal permeability in both Drosophila and a human cell co-culture

ABSTRACT Increased intestinal barrier permeability has been correlated with aging and disease, including type 2 diabetes, Crohn's disease, celiac disease, multiple sclerosis and irritable bowel syndrome. The prevalence of these ailments has risen together with an increase in industrial food processing and food additive consumption. Additives, including sugar, metal oxide nanoparticles, surfactants and sodium chloride, have all been suggested to increase intestinal permeability. We used two complementary model systems to examine the effects of food additives on gut barrier function: a Drosophila in vivo model and an in vitro human cell co-culture model. Of the additives tested, intestinal permeability was increased most dramatically by high sugar. High sugar also increased feeding but reduced gut and overall animal size. We also examined how food additives affected the activity of a gut mucosal defense factor, intestinal alkaline phosphatase (IAP), which fluctuates with bacterial load and affects intestinal permeability. We found that high sugar reduced IAP activity in both models. Artificial manipulation of the microbiome influenced gut permeability in both models, revealing a complex relationship between the two. This study extends previous work in flies and humans showing that diet can play a role in the health of the gut barrier. Moreover, simple models can be used to study mechanisms underlying the effects of diet on gut permeability and function. This article has an associated First Person interview with the first author of the paper. Summary: Sugar and other food additives can inhibit gut barrier function in both human cell co-cultures and Drosophila melanogaster.