Miracle-dz/UniFAR-FTUs huggingface dataset:
ssociation of plasma thioredoxin-1 with renal tubular damage and ardiac prognosis in patients with chronic heart failure

Background: Thioredoxin-1 (Trx-1) is an abundant 12.5 kDa redox protein expressed in almost all eukaryotic cells that protect against the development of heart failure and kidney dysfunction. Plasma Trx-1 levels are considered as a reliable marker for oxidative stress. However, it remains to be determined whether plasma Trx-1 levels can predict cardiac prognosis in patients with chronic heart failure (CHF). Methods and results: We measured plasma Trx-1 levels and urinary 2-microglobulin–creatinine ratio (UBCR), a marker for renal tubular damage, in 156 consecutive patients with CHF and 17 control subjects. The patients were prospectively followed for a median follow-up period of 627 days and 46 cardiac events were observed. The patients with cardiac events had significantly higher plasma Trx-1 levels and UBCR levels than the cardiac event-free patients. Multivariate Cox proportional hazard analysis revealed that an elevated Trx-1 level was independently associated with poor outcome in patients with CHF after adjustment for confounding factors (hazard ratio, 1.74; 95% confidence interval, 1.33–2.29; p < 0.0001). UBCR was increased with higher plasma Trx-1 levels. Kaplan–Meier analysis demonstrated that the highest Trx-1 tertile was associated with the highest risk of cardiac events. Conclusion: Plasma Trx-1 level was associated with renal tubular damage and cardiac prognosis, suggesting that it could be a useful marker to identify patients at high risk for comorbid heart failure and renal tubular damage. © 2014 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
Study of Vitamin-D status in patients with low backache

Introduction: Apart from its established role in calcium homeostasis, studies have found vitamin D to be very much important for the normal maintenance and functioning of the muscles and nerves. Aims: i) To study the vitamin D levels in patients of low back ache ii) compare it with a control population. Methods: The study was designed as a case control study, with 100 cases and 100 controls. Patients with complaint of low backache were included in the study. A sample of venous blood was collected for vitamin D estimation. Results: In this study mean vitamin D level in the case group was found to be 29.19 ng/ml and in the control group 38.45ng/ml. Pvalue was found to be <. 0001. Vitamin D deficiency and insufficiency was found more in females than males in both groups. 77.5% of the female patients and 45% of male patients had below normal vitamin D levels. Conclusion: There is a high possibility that vitamin D deficiency has a role to play in the aetiology of low backache.
ELECTRODE PROCESSES IN IONIC LIQUID SOLVENTS AS MIXTURES OF CHOLINE CHLORIDE WITH UREA , ETHYLENE GLYCOL OR MALONIC ACID

The paper reports studies about electrochemical reduction and oxidation processes in three types of ionic liquids consisted in binary mixtures of choline chloride (ChCl) with urea, ethylene glycol (EG) and malonic acid (MA) at various molar ratios from 2:1 to 1:4. The potential windows on Pt and glassy carbon were determined at 70C by cyclic voltammetry. By comparing to those of eutectic systems, namely ChCl-urea (1:2), ChCl-EG (1:2) and ChCl-MA (1:1), voltammograms from ionic liquids with more or less ChCl content provide information about reduction of choline ion and oxidation of complexed Cl anion.
SAMA Working Paper : A Comparative Study between Islamic and Conventional Banks-The case of Saudi Arabia : A Binary Logistic Regression Approach August 2017 By

The aim of this study is to examine, at bank level performance, the differences between Islamic and conventional banks in Saudi Arabia. Six factors are examined in this study; five of which are internal factors and one of which is an external factor. The data are from Saudi Arabia and consist of panel data for the period 1988 to 2016 from 12 local banks: four Islamic banks (Al Rajhi Bank, Alinma Bank, Bank Aljazira, and Bank Albilad) and eight conventional banks. The study shows a noticeable difference between conventional and Islamic banks in Saudi Arabia in terms of profitability, credit risk, capitalization, efficiency, liquidity, and contribution to economic growth.
MINISTÉRIO DA EDUCAÇÃO UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL - UFRGS

DUARTE, Rosangela. A construcao da musicalidade do professor de educacao infantil: um estudo em Roraima. – Porto Alegre, 2010. 213 f. Tese (Doutorado em Educacao) – Universidade Federal do Rio Grande do Sul. Faculdade de Educacao. Programa de Pos-Graduacao em Educacao, Porto Alegre, 2010. Aiming to investigate the development of musicianship training and practice of Music professor of early childhood education, this study reflects on the role of music as a knowledge to be built and its applications in schools of Boa Vista RR. I chose to reflect and analyze how music is present in this teaching practice, and the conceptions of music that guide the classroom. I observe and discuss how this education professional understands and streamlines the musical knowledge, to think about their ability to work with music in their teaching through an educational and reflective criticism: the Musicalization Workshop. There are two focus of analysis: the musicalization of teacher with a pedagogic background and their teaching practices in early childhood education. The theoretical framework underlying this research addresses the theory of Piaget and the thought of Paulo Freire, based on dialectic-dialogic relationship between teacher and student. To discuss the formation of teachers with a pedagogic background and the music education, I adopted the studies of authors like Bellochio (2000), Kater et al (1998), Penna (2008), Figueiredo (2004), Krobot and Santos (2005). And from the studies of Brito (2003), Fonterrada (2005), Beaumont (2003), Schafer (2001), I did realize the presence of music in early childhood education as an area of knowledge. As methodology I adopted action research, based on the approach suggested by Carr & Kemmis (1986), Elliott (1991), Kemmis & McTaggart (1992), highlighting: the researcher's immersion in the circumstances and context of research, the recognition of the participating subjects as producers of knowledge and practice, and the quest for results as the fruit of a collective consequence of the interaction between researcher and researched. This research is a contribution to debates and discussions on the theory that permeates our practices in order to privilege a distinct area of knowledge building and contribute to the formation of a pre-school teacher, who can act and reflect in and for educational practice.
When Not to Classify: Anomaly Detection of Attacks (ADA) on DNN Classifiers at Test Time

A significant threat to the recent, wide deployment of machine learning–based systems, including deep neural networks (DNNs), is adversarial learning attacks. The main focus here is on evasion attacks against DNN-based classifiers at test time. While much work has focused on devising attacks that make small perturbations to a test pattern (e.g., an image) that induce a change in the classifier's decision, until recently there has been a relative paucity of work defending against such attacks. Some works robustify the classifier to make correct decisions on perturbed patterns. This is an important objective for some applications and for natural adversary scenarios. However, we analyze the possible digital evasion attack mechanisms and show that in some important cases, when the pattern (image) has been attacked, correctly classifying it has no utility---when the image to be attacked is (even arbitrarily) selected from the attacker's cache and when the sole recipient of the classifier's decision is the attacker. Moreover, in some application domains and scenarios, it is highly actionable to detect the attack irrespective of correctly classifying in the face of it (with classification still performed if no attack is detected). We hypothesize that adversarial perturbations are machine detectable even if they are small. We propose a purely unsupervised anomaly detector (AD) that, unlike previous works, (1) models the joint density of a deep layer using highly suitable null hypothesis density models (matched in particular to the nonnegative support for rectified linear unit (ReLU) layers); (2) exploits multiple DNN layers; and (3) leverages a source and destination class concept, source class uncertainty, the class confusion matrix, and DNN weight information in constructing a novel decision statistic grounded in the Kullback-Leibler divergence. Tested on MNIST and CIFAR image databases under three prominent attack strategies, our approach outperforms previous detection methods, achieving strong receiver operating characteristic area under the curve detection accuracy on two attacks and better accuracy than recently reported for a variety of methods on the strongest (CW) attack. We also evaluate a fully white box attack on our system and demonstrate that our method can be leveraged to strong effect in detecting reverse engineering attacks. Finally, we evaluate other important performance measures such as classification accuracy versus true detection rate and multiple measures versus attack strength.
Salmonella and Shigella Among Asymptomatic Street Food Vendors in the Dire Dawa city, Eastern Ethiopia: Prevalence, Antimicrobial Susceptibility Pattern, and Associated Factors

Background: Salmonella and Shigella infections are a common public health problem throughout the world. The risk of getting infections is high, where asymptomatic street food vendors are preparing foods and vending. Current knowledge of antimicrobial susceptibility pattern is essential for appropriate treatment and management of these infections. Objective: This study was aimed to determine the prevalence, antimicrobial susceptibility pattern, and associated factors of Salmonella and Shigella among asymptomatic street food vendors in the Dire Dawa city, Eastern Ethiopia. Methods: A cross-sectional study was conducted among 218 randomly selected asymptomatic street food vendors in the Dire Dawa city, Eastern Ethiopia from May to July 2017. Data on the sociodemographic and associated factors were collected using a pretested structured questionnaire. The stool specimens collected were examined for Salmonella and Shigella using recommended culture methods. The antimicrobial susceptibility test was done using the disk diffusion technique. Data were described using descriptive statistical tools. Logistic regression models were used to identify the factors associated with Salmonella and Shigella infections. A P-value ⩽ . 05 was considered statistically significant. Results: The overall prevalence of Salmonella and Shigella was 8.7% (95% confidence interval: 5.6, 10.3). The most common isolates were Salmonella (6%). Most of the isolates were resistant to amoxicillin (97.7%), ampicillin (89.5%), and tetracycline (68.4%). Almost half (47.4%) of Salmonella isolates were multidrug resistant. Food vendors who did not wash hands with soap after the use of the toilet (adjusted odds ratio: 3.3, 95% confidence interval: 1.2, 7.9), and who had untrimmed fingernails (adjusted odds ratio: 4.4, 95% confidence interval: 1.5, 9.3) had higher odds of Salmonella and Shigella compared with their counterparts. Conclusions: The carrier rate of Salmonella and Shigella was relatively low. Most isolates have developed resistance to amoxicillin, ampicillin, and tetracycline. The odds of Salmonella and Shigella was high among those who lack a habit of hand washing with soap after the use of the toilet and with untrimmed fingernails. Regular screening and appropriate hygienic control measures are needed in place to reduce the risk of infections.
REVIEW: Current understanding of the pathogenesis of Fuchs’ endothelial corneal dystrophy

Fuchs’ endothelial corneal dystrophy (FECD) is the most prominent reason for corneal-endothelial transplantations across the globe. The disease pathophysiology manifests through a combination of various genetic and non-heritable factors. This review provides a comprehensive list of known genetic players that cause FECD, and discusses the prominent pathological features that participate in disease progression, such as channel dysfunction, abnormal extracellular matrix deposition, RNA toxicity, oxidative stress, and apoptosis. Although current practices to correct visual acuity involve surgical intervention, this review also discusses the scope of various non-surgical therapeutics to remedy FECD.
Effect of community-based intervention on improving access to treatment for sick under-five children in hard-to-reach communities in Niger State, Nigeria

Background Access to prompt and appropriate treatment is key to survival for children with malaria, pneumonia and diarrhoea. Community-based services are vital to extending care to remote populations. Malaria Consortium supported Niger state Ministry of Health, Nigeria, to introduce and implement an integrated community case management (iCCM) programme for four years in six local government areas (LGAs). The objective was to increase coverage of effective treatment for malaria, pneumonia and diarrhoea among children aged 2-59 months. Methods The programme involved training, equipping, ongoing support and supervision of 1320 community volunteers (CORPs) to provide iCCM services to their communities in all six LGAs. Demand creation activities were also conducted; these included community dialogues, household mobilization, sensitization and mass media campaigns targeted at programme communities. To assess the level of changes in care seeking and treatment, baseline and endline household surveys were conducted in 2014 and 2017 respectively. For both surveys, a 30×30 multi-stage cluster sampling method was used, the sampling frame being RAcE programme communities. Results Care-seeking from an appropriate provider increased overall and for each iCCM illness from 78% to 94% for children presenting with fever (P < 0.01), from 72% to 91% for diarrhoea cases (P < 0.01), and from 76% to 89% for cases of cough with difficult or fast breathing (P < 0.05). For diagnosis and treatment, the coverage of fevers tested for malaria increased from 34% to 77% (P < 0.001) and ACT treatments from 57% to 73% (<0.005); 56% of cases of cough or fast breathing who sought care from a CORP, had their respiratory rate counted and 61% with cough or fast breathing received amoxicillin. At endline caregivers sought care from CORPs in their communities for most cases of childhood illnesses (84%) compared to other providers at hospitals (1%) or health centres (9%). This aligns with caregivers’ belief that CORPs are trusted providers (94%) who provide quality services (96%). Conclusion Implementation of iCCM with focused demand creation activities can improve access to quality lifesaving interventions from frontline community providers in Nigeria. This can contribute towards achieving SDGs if iCCM is scaled up to hard-to-reach areas of all states in the country.
Outcomes of Trabeculectomy With and Without Mitomycin C in Pseudoexfoliative Glaucoma Compared With Mitomycin C in Primary Open Angle Glaucoma

The aim of this study was to evaluate the outcomes of trabeculectomy with mitomycin C (MMC) in patients with Pseudoexfoliative Glaucoma (PXG) and compare the results with the outcomes of trabeculectomy without MMC in PXG and with MMC in Primary Open Angle Glaucoma (POAG). Ninety eyes (76 patients) submitted to trabeculectomy were included in a one-year retrospective study. Fifty-eight eyes with PXG were divided into group 1 (28 eyes) and group 2 (30 eyes), with and without MMC application respectively. Then, the group 1 results were compared with 32 eyes with POAG that performed trabeculectomy with MMC (group 3). Main outcome measures were intraocular pressure (IOP), number of IOP lowering medications, rate of bleb failure (encapsulation, flattening and/or vascularization) and the number of eyes submitted to surgical procedures after trabeculectomy (needling, 5-fluorouracil (5FU) or 2nd trabeculectomy). Results revealed that compared to trabeculectomy with MMC in POAG and trabeculectomy with MMC in PXG, trabeculectomy without MMC in PXG leads to higher IOP (preoperative mean ± standard deviation [SD] was 28.6 ± 5.4 mmHg in group 1, 32.2 ± 8.2 mmHg in group 2 and 26.1 ± 6.5 mmHg in group 3; and after one year was 13.9 ± 3.9 mmHg in group 1, 16.1 ± 5.9 mmHg in group 2 and 12.5 ± 4.0 mmHg in group 3); higher number of IOP lowering medications (preoperative mean ± SD was 3.1 ± 0.60 in group 1, 2.8 ± 0.81 in group 2 and 3.4 ± 0.76 in group 3; and after one year was 1.1 ± 1.1 in group 1, 1.1 ± 1.0 in group 2 and 0.33 ± 0.89 in group 3); higher prevalence of bleb failure (47% in group 1, 53% in group 2, and 18% in group 3); and increased participation in surgical procedures following trabeculectomy (47% in group 1, 57% in group 2, and 6% in group 3). We concluded that trabeculectomy without MMC in PXG had the worst surgical outcome. Thus, PXG appears to be a potential risk factor for filtration bleb failure. Therefore, it could be considered in surgical protocols of MMC application.
MicroRNAs in endocrine tumors

MicroRNAs (miRNAs) are small, protein noncoding RNAs that regulate gene expression post-transcriptionally. Their role is considered to set the gene expression to the optimal level, or in other words to provide “fine tuning” of gene expression. They regulate essential physiological processes such as differentiation, cell growth, apoptosis and their role is known in tumor development too. At tissue level differential miRNA expression in endocrine disorders including endocrine malignancies has also been reported. A new era of miRNAs-related research started when miRNAs were successfully detected outside of cells, in biofluids, in cell-free environments. Their significant role has been demonstrated in cell-cell communication in tumor biology. Due to their stability circulating miRNAs can serve as potential biomarkers. In common diseases circulating miRNAs can be potentially proposed as screening biomarkers and they are also useful to detect tumor recurrence hence they can be applied in post-surgery follow-up too. MiRNAs as diagnostic markers can also be helpful at tissue level when certain histology diagnosis is challenging. Beside diagnosis, tissue miRNAs have the potential to predict prognosis. Intensive research is carried out regarding endocrine tumors as well in terms of miRNAs. However, until now miRNAs as biomarkers do not applied in routine diagnostics, probably due to the challenging preanalytics. In this review we summarized tissue and circulating miRNAs found in thyroid, adrenal, pituitary and neuroendocrine tumors. We aimed to highlight the most important, selected miRNAs with potential diagnostic and prognostic value both in tissue and circulation. Common miRNAs across different endocrine neoplasms are summarized and miRNAs enriched at 14q31 locus are also highlighted suggesting their general role in tumorigenesis of endocrine glands.
Effect of a 10-Week Aquatic Exercise Training Program on Gross Motor Function in Children With Spastic Cerebral Palsy

Introduction. Cerebral palsy (CP) is caused by an injury to the developing brain, and abnormal gross motor function is a hallmark of CP. Properly structured exercises on land have been reported to be effective in improving functional performance in children with CP while only few have been documented on aquatic therapy. Objective. To investigate the effect of a 10-week aquatic exercise training program on gross motor function in children with spastic CP. Methods. Thirty participants aged 1 to 12 years were randomized into the experimental and control groups. Both groups received manual passive stretching and functional training exercises, depending on their level of motor impairment, either in water (temperature 28°C to 32°C) or on land. Each exercise training session lasted for about 1 hour 40 minutes, twice per week for 10 weeks in both groups. Measurement of gross motor function was done using Gross Motor Function Measure (GMFM-88) at baseline and after 4 weeks, 8 weeks, and 10 weeks of intervention. Both groups were compared for differences in change in gross motor function using Mann-Whitney U test. The level of significance was set at P < . 05. Results. Only the experimental group showed significant improvement (P < .05) in all dimensions of gross motor function except for walking, running, and jumping (P = .112). Statistically significant difference (P < .05) was found between both groups for all dimensions of gross motor function after 10 weeks of intervention. Conclusion. Aquatic exercise training program is effective in the functional rehabilitation of children with spastic CP.
Autophagy Enhancing Contributes to the Organ Protective Effect of Alpha-Lipoic Acid in Septic Rats

Alpha-lipoic acid (ALA) reportedly has protective effects against sepsis, which is a leading cause of mortality worldwide and is associated with multiple organ dysfunction. The present study aimed to investigate further the possible action mechanisms of ALA. Male Sprague-Dawley rats were subjected to cecal ligation and puncture (CLP) in order to establish a sepsis model. The rats received an oral gavage of 200 mg/kg ALA or saline immediately after surgery. The heart rate (HR), left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP) and maximum rising and lowering rates of left ventricular pressure (±dp/dt) were examined for assessing the cardiac function. Blood urea nitrogen (BUN) and serum creatinine levels were assessed for evaluating renal function. Neutrophil gelatinase-associated lipocalin (NAGL) was examined for reflecting acute renal injury. Histopathological alterations of the small intestine were examined by hematoxylin-eosin staining. The ultrastructure of the small intestine and kidney was observed under electron microscopy. The levels of autophagy- and inflammation-associated proteins were determined via western blot analysis. The binding of nuclear factor-kappa B (NF-κB) to DNA was tested via an electrophoretic mobility shift assay. Cell apoptosis was examined using TUNEL staining. ALA treatment improved the survival rate, restored the loss of body weight and pro-inflammatory cytokines production in the serum of CLP-induced septic rats. ALA improved the cardiac and renal functions, downregulated the expression levels of interleukin-1β, tumor necrosis factor-α, and inducible nitric oxide synthase in the myocardium and small intestine of septic rats. ALA treatment also inactivated the NF-κB signaling pathway in the small intestine. An examination of autophagy showed that ALA increased the LC3II/I ratio, upregulated Atg5, Atg7, and beclin-1 and downregulated p62 protein levels in the myocardium, kidney, and small intestine of septic rats, and further promoted autophagosome accumulation in the kidney and small intestine. In addition, ALA could also reduce cell apoptosis in myocardium, kidney and small intestine tissues. These effects can be completely or party inhibited by 3-MA. Our findings suggest that autophagy enhancing may contribute to the organ protective effect of ALA in septic rats.