Miracle-dz/UniFAR-FTUs huggingface dataset:
Immunogenomics of gastrointestinal nematode infection in ruminants – breeding for resistance to produce food sustainably and safely

Gastrointestinal nematode (GIN) infection of ruminants represents a major health and welfare challenge for livestock producers worldwide. The emergence of anthelmintic resistance in important GIN species and the associated animal welfare concerns have stimulated interest in the development of alternative and more sustainable strategies aimed at the effective management of the impact of GINs. These integrative strategies include selective breeding using genetic/genomic tools, grazing management, biological control, nutritional supplementation, vaccination and targeted selective treatment. In this review, the logic of selecting for “resistance” to GIN infection as opposed to “resilience” or “tolerance” is discussed. This is followed by a review of the potential application of immunogenomics to genetic selection for animals that have the capacity to withstand the impact of GIN infection. Advances in relevant genomic technologies are highlighted together with how these tools can be advanced to support the integration of immunogenomic information into ruminant breeding programmes.
Effectiveness of negative campaigning in U.S. Senate elections

ate campaigns with an original aggregate data set and ANES survey data. We ask a simple question: how effective is negative campaigning in helping to get candidates elected? Our results provide no straightforward answer. Generally speaking, but dependent on the opponent's strategy, negative campaigning is relatively effective for challengers, while positive campaigning is more effective for incumbents. Overall, our results do provide clear evidence that the cam? paign "matters. " Democracy is a dialogue between putative leaders and citizens. Campaigns provide the most obvious and the loudest forums for this dialogue. Candidates try to persuade voters to cast a ballot and to support their cause. Voters respond by coming to the polls and selecting their preferred candidates. The quality of the dialogue can wane, however, if candidates speak poorly or if voters close their ears. Concern for the democratic dialogue in the United States often turns to negative campaigning. American politics over the past two decades has experienced a dramatic rise in its use, particularly in political advertising (Ansolabehere and Iyengar 1995; Jamieson 1992; Johnson-Cartee and Copeland 1991; West 1993)? or at least a dramatic increase in the number of political observers decrying its use. Although empirical evidence about the type of political advertisements actually used during this period (much less earlier) is hard to come by, the limited available data do indicate a noticeable increase? at least at the presidential level (Geer 1998a; Kaid and Johnston 1991; West 1993). Negative campaigning may be on the rise because it is generally presumed that these methods, particularly in the form of televised advertising, are an unusually effective means of campaigning, a real advantage to those candidates who have the backbone to employ it. Social psychological theory provides several reasons why negative information ought to be more persuasive than comparable positive information (Kanouse and Hanson 1972). Lau (1982,1985) groups these reasons into two main categories. The first is perceptual: negative information may be more likely than compa? rable positive information to be noticed and processed, thereby having the opportunity to get its message across. The second reason is motivational, based on the greater survival benefits resulting from avoiding costs rather than approaching gains. Less formally, some negative campaigning may be
Chronic depression: medication (nefazodone) or psychotherapy (CBASP) is effective when the other is not.

CONTEXT Although various strategies are available to manage nonresponders to an initial treatment for depression, no controlled trials address the utility of switching from an antidepressant medication to psychotherapy or vice versa. OBJECTIVE To compare the responses of chronically depressed nonresponders to 12 weeks of treatment with either nefazodone or cognitive behavioral analysis system of psychotherapy (CBASP) who were crossed over to the alternate treatment (nefazodone, n = 79; CBASP, n = 61). DESIGN Crossover trial. SETTING Twelve academic outpatient psychiatric centers. PATIENTS There were 140 outpatients with chronic major depressive disorder; 92 (65.7%) were female, 126 (90.0%) were white, and the mean age was 43.1 years. Thirty participants dropped out of the study prematurely, 22 in the nefazodone group and 8 in the CBASP group. INTERVENTIONS Treatment lasted 12 weeks. The dosage of nefazodone was 100 to 600 mg/d; CBASP was provided twice weekly during weeks 1 through 4 and weekly thereafter. MAIN OUTCOME MEASURES The 24-item Hamilton Rating Scale for Depression, administered by raters blinded to treatment, the Clinician Global Impressions-Severity scale, and the 30-item Inventory for Depressive Symptomatology-Self-Report. RESULTS Analysis of the intent-to-treat sample revealed that both the switch from nefazodone to CBASP and the switch from from CBASP to nefazodone resulted in clinically and statistically significant improvements in symptoms. Neither the rates of response nor the rates of remission were significantly different when the groups of completers were compared. However, the switch to CBASP following nefazodone therapy was associated with significantly less attrition due to adverse events, which may explain the higher intent-to-treat response rate among those crossed over to CBASP (57% vs 42%). CONCLUSIONS Among chronically depressed individuals, CBASP appears to be efficacious for nonresponders to nefazodone, and nefazodone appears to be effective for CBASP nonresponders. A switch from an antidepressant medication to psychotherapy or vice versa appears to be useful for nonresponders to the initial treatment.
Development and Validation of RAPID: A Patient-Specific Monte Carlo Three-Dimensional Internal Dosimetry Platform.

This work describes the development and validation of a patient-specific Monte Carlo internal dosimetry platform called RAPID (Radiopharmaceutical Assessment Platform for Internal Dosimetry). RAPID utilizes serial PET/CT or SPECT/CT images to calculate voxelized three-dimensional (3D) internal dose distributions with the Monte Carlo code Geant4. RAPID's dosimetry calculations were benchmarked against previously published S-values and specific absorbed fractions (SAFs) calculated for monoenergetic photon and electron sources within the Zubal phantom and for S-values calculated for a variety of radionuclides within spherical tumor phantoms with sizes ranging from 1 to 1000 g. The majority of the S-values and SAFs calculated in the Zubal Phantom were within 5% of the previously published values with the exception of a few 10 keV photon SAFs that agreed within 10%, and one value within 16%. The S-values calculated in the spherical tumor phantoms agreed within 2% for 177Lu, 131I, 125I, 18F, and 64Cu, within 3.5% for 211At and 213Bi, within 6.5% for 153Sm, 111In, 89Zr, and 223Ra, and within 9% for 90Y, 68Ga, and 124I. In conclusion, RAPID is capable of calculating accurate internal dosimetry at the voxel-level for a wide variety of radionuclides and could be a useful tool for calculating patient-specific 3D dose distributions.
Computational Modeling of Human Multimodal Language : The MOSEI Dataset and Interpretable Dynamic Fusion

Computational modeling of human multimodal language is an emerging research area in natural language processing spanning the language, visual and acoustic modalities. Comprehending multimodal language requires not only the modeling of interactions within each modality (intramodal interactions), but more importantly the interactions between modalities (crossmodal interactions). Modeling these interactions lie at the core of multimodal language analysis. From a resource perspective, there is a genuine need for large scale datasets that allow for in-depth studies of human multimodal language. In this paper we introduce Multimodal Opinion Sentiment and Emotion Intensity (MOSEI), the largest dataset for multimodal sentiment analysis and emotion recognition. In addition, we propose a novel multimodal fusion technique called the Graph Memory Fusion Network (GMFN) that dynamically fuses modalities in a hierarchical manner. Using data from MOSEI and GMFN, we conduct experiments to investigate the hierarchical interactions between modalities in human multimodal language. Unlike previously proposed fusion techniques, GMFN is highly interpretable and achieves superior performance when compared to the previous state of the art, demonstrating that GMFN is highly suitable for multimodal language analysis.
Simulating Southern Hemisphere extra-tropical climate variability with an idealised coupled atmosphere-ocean model

Abstract. A quasi-geostrophic model of Southern Hemisphere's wintertime atmospheric circulation with horizontal resolution T21 has been coupled to a global ocean circulation model with a resolution of 2° × 2° and simplified physics. This simplified coupled model reproduces qualitatively some features of the first and the second EOF of atmospheric 833 hPa geopotential height in accordance with NCEP data. The variability patterns of the simplified coupled model have been compared with variability patterns simulated by four complex state-of-the-art coupled CMIP5 models. The first EOF of the simplified model is too zonal and does not reproduce the right position of the centre of action over the Pacific Ocean and its extension to the tropics. The agreement in the second EOF between the simplified and the CMIP5 models is better. The total variance of the simplified model is weaker than the observational variance and those of the CMIP5 models. The transport properties of the Southern Ocean circulation are in qualitative accord with observations. The simplified model exhibits skill in reproducing essential features of decadal and multi-decadal climate variability in the extratropical Southern Hemisphere. Notably, 800 yr long coupled model simulations reveal sea surface temperature fluctuations on the timescale of several decades in the Antarctic Circumpolar Current region.
Edible films from Polysaccharides

Edible films and coatings have received considerable attention in recent years because of their advantages including use as edible packaging materials over synthetic films. This could contribute to the reduction of environmental pollution. By functioning as barriers, such edible films and coatings can feasibly reduce the complexity and thus improve the recyclability of packaging materials, compared to the more traditional non-environmental friendly packaging materials, and may be able to substitute such synthetic polymer films. New materials have been developed and characterized by scientists, many from abundant natural sources that have traditionally been regarded as waste materials. The objective of this review is to provide a comprehensive introduction to edible coatings and films by providing descriptions of suitable materials, reviewing their properties and describing methods of their applications and potential uses. Keywords : Edible film, coatings, characteristics, environmental friendly
Outcomes According to Discharge Location for Persons Who Inject Drugs Receiving Outpatient Parenteral Antimicrobial Therapy

Abstract Background Opioid use disorder poses a significant public health risk. Persons who inject drugs (PWID) suffer from high mortality and morbidity secondary to serious infectious diseases, often requiring prolonged courses of outpatient parenteral antibiotics. The goal of this study was to determine the outcomes of PWID discharged to home or to a skilled nursing or rehabilitation facility (SNF/rehab) with parenteral antibiotic treatment under an outpatient parenteral antimicrobial therapy (OPAT) program. Methods This is a retrospective observational study. The study population was identified via hospital and OPAT databases using substance use disorder diagnoses and confirmed through chart review. The study population included hospitalized PWID with injection drug use in the preceding 2 years who were discharged between 2010 and 2015 to complete at least 2 weeks of parenteral antibiotics and monitored by the OPAT program. Retrospective chart review was used to describe patient characteristics and outcomes. Results Fifty-two patients met inclusion criteria, 21 of whom were discharged to home and 31 were discharged to a SNF/rehab. Of the patients discharged to home, 17 (81%) completed their planned antibiotic courses without complication. Twenty (64%) patients discharged to a SNF/rehab completed the antibiotic courses without complication. Six (11%) patients had line infections, 6 (11%) had injection drug use relapse, and 12 (23%) required readmission. Conclusions Persons who inject drugs discharged home were not more likely to have complications than those discharged to a SNF/rehab. Home OPAT may be a safe discharge option in carefully selected patients.
The Variety of Deconversion Experiences: Contours of a Concept in Respect to Empirical Research 1

This article presents an outline of historical and situational arguments which suggest a focus on deconversion, an outline of conversion research and its consequences for deconversion, and a discussion of extant empirical research on deconversion. The discussion then focuses on the conceptualization of deconversion and compiles the features from which a comprehensive concept of deconversion may emerge. The core features of the deconversion concept which is suggested in this article are complemented by dimensions of diversity which also include a developmental perspective (from the religious styles perspective). This has implications for future research.
Porcine rotavirus C in pigs with gastroenteritis on Thai swine farms, 2011–2016

Swine are economically important food animals, but highly contagious porcine epidemic diarrhea virus (PEDV) and rotavirus can afflict pig herds and contribute significantly to piglet morbidity and mortality. While there have been studies on rotavirus group A (RVA) in Thailand, reports of rotavirus group C (RVC) are limited. Here, we aimed to identify the prevalence of RVC circulating on Thai commercial swine farms. We analyzed 769 feces and intestine mucosal contents of pigs affected with diarrhea between 2011 and 2016 using RT-PCR specific for the PEDV spike (S), rotavirus glycoprotein (G) VP7, and protease-sensitive protein (P) VP4 genes. We found that 6.6% (51/769) of samples tested positive for RVC, of which 11 samples were co-infected with RVA and four samples were co-infected with PEDV. Three samples tested positive for all three viruses. Phylogenetic analysis of the VP7 gene showed that the most frequent RVC genotype was G1, which grouped with the prototypic RVC Cowden strain. While G6 and G9 were also common, G3 was relatively rare. Analysis of the VP4 gene revealed that the most common P type was P[5], followed by P[4], P[7], and P[1]. In all, there were six G/P combinations (G6P[5], G1P[1], G1P[4], G1P[5], G9P[4], and G9P[7]), of which G6P[5] was the most predominant.
Interlaboratory Reproducibility of Blood Morphology Using the Digital Microscope

Differential counting of peripheral blood cells is an important diagnostic tool. However, manual morphological analysis using the microscope is time-consuming and requires highly trained personnel. The digital microscope is capable of performing an automated peripheral blood cell differential, which is as reliable as manual classification by experienced laboratory technicians. To date, information concerning the interlaboratory variation and quality of cell classification by independently operated digital microscopy systems is limited. We compared four independently operated digital microscope systems for their ability in classifying the five main peripheral blood cell classes and detection of blast cells in 200 randomly selected samples. Set against the averaged results, the R2 values for neutrophils ranged between 0.90 and 0.96, for lymphocytes between 0.83 and 0.94, for monocytes between 0.77 and 0.82, for eosinophils between 0.70 and 0.78, and for blast cells between 0.94 and 0.99. The R2 values for the basophils were between 0.28 and 0.34. This study shows that independently operated digital microscopy systems yield reproducible preclassification results when determining the percentages of neutrophils, eosinophils, lymphocytes, monocytes, and blast cells in a peripheral blood smear. Detection of basophils was hampered by the low incidence of this cell class in the samples.
Docetaxel secretion in tears: association with lacrimal drainage obstruction.

OBJECTIVE To test the hypothesis that docetaxel may be secreted in tears after intravenous infusion. DESIGN Prospective pilot trial. PATIENTS AND METHODS Tear fluid was collected from 4 patients receiving docetaxel weekly and 2 patients receiving docetaxel every 3 weeks as a single agent for the treatment of metastatic breast cancer. Tear samples were collected once prior to and again within 30 minutes following the end of the 1-hour docetaxel infusion. A blood sample was also obtained after infusion. The tear and plasma samples were analyzed for drug content using high-performance liquid chromatography and tandem mass spectrometry. RESULTS Docetaxel was found in the tear samples collected from all 6 patients. CONCLUSION The secretion of docetaxel in tears may be a mechanism for canalicular inflammation and tear drainage obstruction, which are known to occur as an adverse effect of the drug.
Neuroprotection by misoprostol against rotenone-induced neurotoxicity in rat brain

Objective: To investigate the effect of the prostaglandin E1 analogue misoprostol on oxidative stress and neurodegeration caused by subcutaneous rotenone administration in rats. Methods: Rotenone was administered in a dose of 1.5 mg/kg every other day for 2 weeks. Starting from the 1st day of rotenone injection, rats were subcutaneously treated with misoprostol at doses of 10, 100 or 1 000 μ g/kg. Rats were evaluated for brain lipid peroxidation (malondialdehyde: MDA), reduced glutathione (GSH), nitric oxide (NO) levels, and paraoxonase-1 (PON-1) activity. The concentrations of the anti-apoptotic protein B cell/lymphoma-2 (Bcl-2) were determined in the striatum. Histopathologic examination and the expression of inducible nitric oxide synthase (iNOS) in the cerebral cortex and striatum were also performed. Results: Compared with the vehicle-treated group, rotenone caused a significant increase in brain lipid proxidation (MDA) by 61% (P<0.05) accompanied by an increase in NO by 73.1% (P<0.05) and a decrease in GSH concentration by 29.4% (P<0.05). In addition, brain PON-1 activity significantly decreased by 63.0% (P<0.05) and striatal Bcl-2 significantly decreased by 27.9% (P<0.05) with respect to the corresponding control value. Brain sections from rotenone treated rats showed extensive dark pyknotic and apoptotic nuclei in neurons, shrunken cytoplasm and perineuronal vacuolation. Rotenone also caused pronounced expression of iNOS in the cerebral cortex and striatum. Treatment with misoprostol at doses of 100 and 1 000 μ g/kg resulted in decreased brain MDA (by 16.5%-23.0%) (P<0.05) and NO levels (by 37.1%-40.7%) (P<0.05) and increased GSH concentrations (by 18.8%-30.1%) (P<0.05). PON-1 activity was significantly increased by 80.0%-114.8% (P<0.05) by misoprostol at 100 and 1 000 μ g/kg, respectively. In addition, misoprostol treatment restored striatal Bcl-2 concentrations to its normal value. Misoprostol treatment resulted in markedly reduced brain injury and decreased iNOS expression in the cerebral cortex and striatum of rotenone intoxicated rats. Conclusions: These data suggest that misoprostol prevents the rotenone-induced neurodegeneration in rat brain by reducing brain oxidative stress.
Absence of phosphocreatine resynthesis in human calf muscle during ischaemic recovery.

Changes in the metabolites phosphocreatine (PCr), Pi and ATP were quantified by 31P n.m. r. spectroscopy in the human calf muscle during isometric contraction and recovery under ischaemic conditions. Time resolution of the measurements was 10 s. During a 30-60 s ischaemic isometric contraction, PCr decreased linearly at a rate of 1.17%/s (relative to the resting value) at a contraction strength equivalent to 70% of the maximal voluntary contraction (MVC) and at a rate of 2.43%/s at 90% MVC. There was a corresponding increase in Pi but the concentration of ATP did not change. pH decreased linearly during contraction by 4.22 and 8.23 milli-pH units/s at 70 and 90% MVC respectively. During a subsequent 5 min interval of ischaemic recovery, PCr, Pi, ATP, phosphomonoesters and calculated free ADP, free AMP and pH retained the value they had attained by the end of contraction with no significant recovery. Thus it is concluded that anaerobic glycolysis and glycogenolysis is halted momentarily on termination of contraction and that PCr is not resynthesized during ischaemic recovery. This paradoxical arrest of glycolytic flow in spite of the very significantly elevated concentration of potent activators such as Pi and free AMP clearly indicates that parameters other than PCr, ATP, Pi, calculated pH, free ADP and free AMP regulate glycolysis and glycogenolysis of human skeletal muscle very efficiently under ischaemic conditions.
In Vivo Safety Studies With SPBN GASGAS in the Frame of Oral Vaccination of Foxes and Raccoon Dogs Against Rabies

In order to obtain Marketing Authorization for an oral rabies vaccine in the European Union, not only safety studies in the target species, red fox and raccoon dog, are required. Since baits are distributed unsupervised in the environment, specific safety studies in selected non-target species are compulsory. Furthermore, oral rabies vaccines are based on live, replication-competent viruses and thus distinct safety studies in the target species for such type of vaccines are also mandatory. Here, the results of these safety studies in target and selected non-target species for a 3rd generation oral rabies virus vaccine construct, SPBN GASGAS (Rabitec), are presented. The studies included the following species; red fox, raccoon dog, domestic dog, domestic cat, domestic pig, wild rodents. The following safety topics were investigated; overdose, repeated dose, dissemination, shedding, horizontal and vertical transmission. It was shown that SPBN GASGAS did not cause disease or any other adverse reaction in vaccinated animals and naïve contact animals. The vaccine did not disseminate within the host beyond the site of entry. No horizontal transmission was observed in wild rodents. In the target species, there was evidence that in a few cases horizontal transmission of vaccine virus could have occurred under these experimental conditions; most likely immediately after vaccine administration. The vaccine construct SPBN GASGAS meets therefore the latest revised minimal safety requirements as laid down in the European Pharmacopoeia.
The Meaning of Being Supportive for Family Caregivers as Narrated by Registered Nurses Working in Palliative Homecare

The aim of this study was to illuminate the meaning of being supportive to family caregivers who care for a relative at home as narrated by registered nurses. The context used to allow for the meaning of being supportive to be illuminated was palliative home care. The study uses a phenomenological-hermeneutical method inspired by the philosophy of Ricoeur. Data consisted of narrative interviews, which were analyzed in three recurring phases: naive reading, structural analyses and interpreted whole. Twenty nurses from the hospitals in Sweden participated in the study. Two core themes were found: forming a relationship and keeping caregiving at home.