Miracle-dz/UniFAR-FTUs huggingface dataset:
[Detection of Epstein-Barr virus in breast cancers with lymphoid stroma].

OBJECTIVE the purpose of our work is to detect Epstein-Barr virus (EBV) in 2 types of breast cancer: medullary carcinoma and high grade invasive ductal carcinoma with lymphoid stroma. PATIENTS AND METHODS we proceeded to a retrospective study of 18 medullary carcinoma and 18 high grade invasive ductal carcinoma with lymphoid stroma. The detection of the virus was carried out by immunohistochemistry with anti-LMP2 antibody and by hybridization in situ by oligonucleotides EBER1 and EBER1. LMP1 as well as hybridization in situ were positive in 5 tumors (3 medullary carcinoma and 2 high grade invasive ductal carcinoma with lymphoid stroma). RESULTS positivity was observed in tumor cells and neither in epithelial non tumoral ones nor in lymphoid cells. DISCUSSION AND CONCLUSIONS during numerous years, correlations between the replication of EBV and the appearance of a malignant phenotype were limited to nasopharyngeal carcinoma and to lymphoid cells. A controversy regarding the association of EBV with breast cancers has recently been reported in the literature. This cancer being very frequent, the involvement of EBV even in a small proportion of breast cancers could have important implications. Our results suggest a possible implication of EBV in these tumours but other studies are necessary.
Clinical Characteristics of Dogs with Progressive Myelomalacia Following Acute Intervertebral Disc Extrusion

Background Progressive myelomalacia (PMM) is a catastrophic disease associated with acute intervertebral disc extrusion (IVDE). Published data on the clinical characteristics of this disease are limited. Objective To describe the onset and progression of clinical signs of PMM in a large case cohort. Animals Fifty‐one dogs, 18 with histopathologically confirmed PMM, 33 presumptively diagnosed based on clinical signs and diagnostic imaging. Methods Retrospective study. Dogs with confirmed IVDE and either a histopathologic diagnosis of PMM or a high clinical suspicion were identified by medical record search. Data on nature and progression of signs were extracted. Results Twenty‐four of 51 dogs were Dachshunds. T12–T13 was the most common site of disc extrusion (12 of 56), and 18 of 55 of mid‐to‐caudal lumbar discs (between L3 and L6) were affected. Onset of PMM signs ranged from present at first evaluation (17/51) to 5 days after presentation, with 25 of 51 cases developing signs within 48 hours. Progression of signs from onset of PMM to euthanasia or death, excluding 7 cases euthanized at presentation, ranged from 1 to 13 days with 23 being euthanized within 3 days. Nonspecific systemic signs were documented in 30 of 51 dogs. Conclusion and Clinical Importance The majority of dogs developed PMM within 2 days of presentation and was euthanized within another 3 days. However, onset can be delayed up to 5 days after presentation with progression to euthanasia taking as long as 2 weeks. Mid‐to‐caudal lumbar discs might be associated with an increased risk of PMM.
In Vivo Virtual Biopsy of Human Skin by Using Noninvasive Higher Harmonic Generation Microscopy

Higher harmonic generation microscopy (HHGM), combining both second- and third-harmonic generation (SHG and THG) modalities, is a new paradigm for in vivo noninvasive virtual biopsy. With the ability to achieve noninvasiveness, high resolution, and high penetrability at the same time, HHGM is a promising tool for future noninvasive diagnosis of skin diseases. In this paper, we report our preliminary pilot clinical trial results on in vivo virtual biopsy of human skin by using HHGM. In vivo virtual biopsy imaging has been performed on 21 volunteers' inside and outside forearm skin along with the damage evaluation. Together with an embryo viability study, our results not only indicate a superior viability performance of the developed system, but also a much improved penetrability in different skin types. Ex vivo studies further confirm the capability of the developed virtual biopsy system to pathohistologically distinguish different skin diseases. Our in vivo HHGM biopsy study of human skin with different colors also reveals the central role of melanin in the epi-THG resonance enhancement and attenuation. With a unique capability to molecular image the melanin distribution, epi-THG microscopy is also highly valuable for diagnosing and screening early melanocytic lesions.
IMMUNOHISTOCHEMICAL DEMONSTRATION OF ORNITHINE DECARBOXYLASE IN DEVELOPING RAT KIDNEY

The distribution of L-ornithine decarboxylase was studied in developing rat kidneys by use of peroxidase-antiperoxidase technique. At postnatal day 2 the immunoreaction was exclusively localized in tubule cells. The glomeruli were devoid of immunostaining. A drastic decline of staining intensity occurred during the first two weeks of postnatal ontogenesis.
Phylogenetic relationships of the five extant Rhinoceros species (Rhinocerotidae, Perissodactyla) based on mitochondrial cytochrome b and 12S rRNA genes.

A major question in rhinocerotid phylogenetics concerns the position of the Sumatran rhinoceros (Dicerorhinus sumatrensis) with regard to the other extant Asian (Rhinoceros unicornis and R. sondaicus) and African (Diceros bicornis and Ceratotherium simum) species. We have examined this particular question through the phylogenetic analysis of the complete sequences of the mitochondrial 12S rRNA and cytochrome b genes. Three additional perissodactyls (one tapir and two equids) plus several outgroup cetartiodactyls were included in the analysis. The analysis identified a basal rhinocerotid divergence between the African and the Asian species, with the Sumatran rhinoceros forming the sister group of the genus Rhinoceros. We estimate the Asian and African lineages to have diverged at about 26 million years before present.
Standing on the shoulders of giants? A critical review of empirical talent management research

Purpose – The purpose of this paper is to frame empirical literature on talent management (TM), and to provide a clear and comprehensive picture of the topics under investigation, the conceptualization of TM, and under-explored areas. Design/methodology/approach – The authors adopted a systematic review that covers empirical research on TM which has been published between 2006 and 2014 in academic peer-reviewed journals. A total of 96 articles were included in the review. A bibliometric as well as a content analysis has been carried out. Findings – The results reveal that the Anglo-Saxon context (in particular EU) has a great impact on empirical TM research. Also research foundations and designs are not very rigorous. A slight awareness of context and culture was found. Empirical TM research is predominantly built on an exclusive approach to TM. Yet, how TM works in practice and how well (from the perspective of multiple actors) as well as the role and perceptions of line managers are under-explored areas.
Anti‐inflammatory effects of macrolides in lung disease *

During the past five decades there has been increasing interest in the potential anti‐inflammatory effects of macrolide antibiotics. Low‐dose macrolide therapy has dramatically increased survival in patients with diffuse panbronchiolitis, a disease with many similarities to cystic fibrosis (CF). This has led to further investigation into the potential use of macrolides in chronic lung diseases with an inflammatory component. This review summarizes the proposed anti‐inflammatory mechanisms for this group of antibiotics, and examines the effect of macrolides on modulation of the inflammatory pathways, neutrophil function, bronchoconstriction, Pseudomonas biofilm, mucus rheology, bacterial adherence, and multidrug‐resistant protein. It discusses the current status of clinical studies in children with CF, bronchiectasis, and asthma. While there are much in vitro data for different proposed anti‐inflammatory effects, randomized controlled clinical trials in children with CF, bronchiectasis, and asthma are still just beginning. The benefits and potential side effects need to be determined before routine use can be advised. Pediatr Pulmonol. 2001; 31:464–473. © 2001 Wiley‐Liss, Inc.
Hyperglycemia alters tumor necrosis factor-alpha release from mononuclear cells in women with polycystic ovary syndrome.

CONTEXT Women with polycystic ovary syndrome (PCOS) are often insulin resistant and have chronic low-level inflammation. OBJECTIVE The purpose of this study was to determine the effects of hyperglycemia on lipopolysaccharide (LPS)-stimulated TNFalpha release from mononuclear cells (MNC) in PCOS. DESIGN The study was designed as a prospective controlled study. SETTING The study was carried out at an academic medical center. PATIENTS Sixteen reproductive age women with PCOS (eight lean, eight obese) and 14 age-matched controls (eight lean, six obese) participated in the study. MAIN OUTCOME MEASURES Insulin sensitivity (IS) was derived from a 2-h 75-g oral glucose tolerance test (IS(OGTT)). Percentage of truncal fat was determined by dual-energy absorptiometry. TNFalpha release was measured from MNC cultured in the presence of LPS from blood samples drawn fasting and 2 h after glucose ingestion. RESULTS IS(OGTT) was lower in women with PCOS compared with controls (3.9 +/- 0.4 vs. 6.3 +/- 1.0; P < 0.03) and was negatively correlated with percentage of truncal fat (r = 0.56; P < 0.002). Truncal fat was greater in lean women with PCOS compared with lean controls (29.8 +/- 2.6 vs. 23.8 +/- 2.5%; P < 0.04). The TNFalpha response was different between obese and lean controls (-96.9 +/- 21.2 vs. 24.4 +/- 21.6 pg/ml; P < 0.03) and obese and lean women with PCOS (-94.1 +/- 34.5 vs. 30.4 +/- 17.6 pg/ml; P < 0.002). Fasting plasma C-reactive protein was elevated (P < 0.003) in obese PCOS and obese controls compared with lean controls. CONCLUSION An increase in abdominal adiposity and increased TNFalpha release from MNC after hyperglycemia may contribute to insulin resistance in lean PCOS patients. In contrast, obese PCOS patients have more profound chronic inflammation, and thus may have LPS tolerance that protects them from relatively mild excursions in blood glucose.
Putative heterotopic ossification progenitor cells derived from traumatized muscle

Heterotopic ossification (HO) is a frequent complication following combat‐related trauma, but the pathogenesis of traumatic HO is poorly understood. Building on our recent identification of mesenchymal progenitor cells (MPCs) in traumatically injured muscle, the goal of this study was to evaluate the osteogenic potential of the MPCs in order to assess the role of these cells in HO formation. Compared to bone marrow‐derived mesenchymal stem cells (MSCs), a well‐characterized population of osteoprogenitor cells, the MPCs exhibited several significant differences during osteogenic differentiation and in the expression of genes related to osteogenesis. Upon osteogenic induction, MPCs showed increased alkaline phosphatase activity, production of a mineralized matrix, and up‐regulated expression of the osteoblast‐associated genes CBFA1 and alkaline phosphatase. However, MPCs did not appear to reach terminal differentiation as the expression of osteocalcin was not substantially up‐regulated. With the exception of a few genes, the osteogenic gene expression profile of traumatized muscle‐derived MPCs was comparable to that of the MSCs after osteogenic induction. These findings indicate that traumatized muscle‐derived MPCs have the potential to function as osteoprogenitor cells when exposed to the appropriate biochemical environment and are the putative osteoprogenitor cells that initiate ectopic bone formation in HO. © 2009 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 27:1645–1651, 2009
Using spatial features for classification of combined motions based on common spatial pattern

Motion recognition is an important application of electromyography (EMG) analysis. While discrete motions such as hand open, hand close and wrist pronation have been extensively investigated, studies on combined motions involving two or more degrees of freedom (DOFs) are relatively few and the classification accuracy of the combined motions reported in previous studies is barely satisfactory. To improve the accuracy of the combined motion recognition, common spatial pattern (CSP) was employed in this study to extract spatial features. 18 forearm motion classes, consisted of 8 discrete motions and 10 combined motions, were classified by the proposed method. Our results showed that the accuracy rate of CSP features was 96.3%, which outperformed the commonly used time-domain (TD) features by 2.4% and TD combined with auto-regression coefficients (TDAR) by 0.6%. Moreover, CSP features cost noticeable much less time than TDAR and quite less time than TD in testing. These results suggest that CSP features could be a better feature set for multi-DOF myoelectric control than conventional features.
Psychometric Properties of a Brief Version of the Escala de Satisfação com o Suporte Social for Children and Adolescents

The main objective of this study was to develop a brief versión of the Escala de Satisfação com o Suporte Social for children and adolescents (Ribeiro, 1999). A representative sample of 3195 children and adolescents was obtained from 5th and 7th graders throughout all five Portuguese regions. The results showed a good internal consistency for the social support satisfaction factor, α = 0.84; acceptable for the necessity for activities connected to social support factor, α = 0.69. By using ANOVA, gender, age and socioeconomic status related differences were identified. A confirmatory factorial analysis was done and an adjusted model was found by taking off item 5. The concurrent validity was inspected with measures related to social support, such as optimism, self-worth and perceptions of health related quality of life. With this analysis, we verified that women and younger participants (< 12 years) showed a higher social support satisfaction. Medium-high socioeconomic status participants showed a higher negative social support satisfaction. These results suggest the validity of the scale in assesing perceptions of social support. El objetivo principal de este estudio fue desarrollar una versión breve de la Escala de Satisfacción con el apoyo social (ESSS) de Ribeiro (1999) para niños, niñas y adolescentes. Una muestra representativa de 3195 niños y adolescentes se obtuvo de alumnos de 5⍛ y 7⍛ grados de las cinco regiones portuguesas. Los resultados mostraron una buena consistencia interna para el factor de satisfacción con el apoyo social, α = 0, 84; y aceptable para el factor de necesidad de actividades conectadas al apoyo social, α = 0, 69. Se identificaron las diferencias relativas al género, edad y status socioeconómico a través de ANOVA. Se llevó a cabo un análisis factorial confirmatorio y se llegó a un modelo ajustado retirando el item 5. Se comprobó la validez concurrente con variables relacionadas con el apoyo social, incluido el optimismo, la autoestima y la percepción subjetiva de la calidad de vida relacionada con la salud. Los análisis mostraron que son las chicas y los sujetos menores de 12 años los que informan de mayor satisfacción con el apoyo social percibido. Los sujetos de status socioeconómico medio-alto mostraron una satisfacción más alta con el apoyo social negativo. Los resultados parecen confirman la validez de la escala para la evaluación del apoyo social percibido.
Chronic Gαs Signaling in the Striatum Increases Anxiety-Related Behaviors Independent of Developmental Effects

Current research in the field of anxiety disorders is largely receptor-centric, leaving intracellular pathways largely unexplored. Gαs, the G-protein which stimulates adenylyl cyclase and L-type voltage-gated calcium channels, may be one intracellular molecule regulating anxiety-related behaviors as increased efficacy of Gαs signaling has been noted in patient populations that suffer from anxiety. We report here anxiety-related behaviors in two lines of transgenic mice expressing a constitutively active isoform of Gαs (or Gαs*). The first line expressed Gαs* throughout postnatal forebrain neurons, while the second line of mice conditionally expressed Gαs* selectively in the striatum (Gαs*str mice). In the open field, both lines of mice showed a significant preference for the periphery suggesting that expression of Gαs* in the striatum alone was sufficient to produce an anxiogenic phenotype. In the light/dark box, Gαs*str mice exhibited longer latencies to enter the light and spent significantly less time in the lit compartment. Similarly, Gαs*str mice showed longer latencies to enter the open quadrants and spent less time in the open quadrants of the elevated zero maze. Interestingly, these anxiety-related phenotypes were largely unrelated to developmental effects as mice expressing the Gαs*str transgene during development, but not at testing, were normal on most measures. These observations show that chronic Gαs signaling in the striatum is sufficient to trigger anxiety-related behaviors largely independent of developmental effects and suggest the cAMP pathway or L-type voltage-gated calcium channels may be viable targets for future pharmacological intervention in the treatment of anxiety disorders.
DUST OBSCURATION AND METALLICITY AT HIGH REDSHIFT: NEW INFERENCES FROM UV, Hα, AND 8 μm OBSERVATIONS OF z ∼ 2 STAR-FORMING GALAXIES

We use a sample of 90 spectroscopically confirmed Lyman break galaxies with Hα measurements and Spitzer MIPS 24 μm observations to constrain the relationship between rest-frame 8 μm luminosity (L8) and star formation rate (SFR) for L* galaxies at z ∼ 2. We find a tight correlation with 0.24 dex scatter between L8 and Hα luminosity/SFR for z ∼ 2 galaxies with 1010 L☉ ≲ LIR ≲ 1012 L☉. Employing this relationship with a larger sample of 392 galaxies with spectroscopic redshifts, we find that the UV slope β can be used to recover the dust attenuation of the vast majority of moderately luminous L* galaxies at z ∼ 2 to within a 0.4 dex scatter using the local correlation. Separately, young galaxies with ages ≲100 Myr appear to be less dusty than their UV slopes would imply based on the local trend and may follow an extinction curve that is steeper than what is typically assumed. Consequently, very young galaxies at high redshift may be significantly less dusty than inferred previously. Our results provide the first direct evidence, independent of the UV slope, for a correlation between UV and bolometric luminosity (Lbol) at high redshift, in the sense that UV-faint galaxies are on average less infrared and less bolometrically luminous than their UV-bright counterparts. The Lbol–LUV relation indicates that as the SFR increases, LUV turns over (or “saturates”) around the value of L* at z ∼ 2, implying that dust obscuration may be largely responsible for modulating the bright end of the UV luminosity function. Finally, dust attenuation is found to correlate with oxygen abundance at z ∼ 2. Accounting for systematic differences in local and high-redshift metallicity calibrations, we find that L* galaxies at z ∼ 2, while at least an order of magnitude more bolometrically luminous, exhibit ratios of metals to dust that are similar to those of local starbursts. This result is expected if high-redshift galaxies are forming their stars in a less metal-rich environment compared to local galaxies of the same luminosity, thus naturally leading to a redshift evolution in both the bolometric luminosity–metallicity and bolometric luminosity–obscuration relations.
ABI4 Activates DGAT1 Expression in Arabidopsis Seedlings during Nitrogen Deficiency1[C][W][OA]

Triacylglycerol (TAG) is the major seed storage lipid and is important for biofuel and other renewable chemical uses. Acyl-coenzyme A:diacylglycerol acyltransferase1 (DGAT1) is the rate-limiting enzyme in the TAG biosynthesis pathway, but the mechanism of its regulation is unknown. Here, we show that TAG accumulation in Arabidopsis (Arabidopsis thaliana) seedlings increased significantly during nitrogen deprivation (0.1 mm nitrogen) with concomitant induction of genes involved in TAG biosynthesis and accumulation, such as DGAT1 and OLEOSIN1. Nitrogen-deficient seedlings were used to determine the key factors contributing to ectopic TAG accumulation in vegetative tissues. Under low-nitrogen conditions, the phytohormone abscisic acid plays a crucial role in promoting TAG accumulation in Arabidopsis seedlings. Yeast one-hybrid and electrophoretic mobility shift assays demonstrated that ABSCISIC ACID INSENSITIVE4 (ABI4), an important transcriptional factor in the abscisic acid signaling pathway, bound directly to the CE1-like elements (CACCG) present in DGAT1 promoters. Genetic studies also revealed that TAG accumulation and DGAT1 expression were reduced in the abi4 mutant. Taken together, our results indicate that abscisic acid signaling is part of the regulatory machinery governing TAG ectopic accumulation and that ABI4 is essential for the activation of DGAT1 in Arabidopsis seedlings during nitrogen deficiency.
Stock Market Reaction To Estimates Of Earnings Per Share By Company Officials

Recent papers have examined the stock market reaction to a variety of information generating events, e.g., stock splits [10], annual and quarterly earnings announcements [1, 3, 7, 8], and announcements of discount rate changes by the Federal Reserve Bank [20]. This paper examines the stock market reaction to another potential information generating event, i.e., estimates of annual earnings per share by company officials. These estimates are made after the end of the financial year, but before the release of audited earnings figures. Three kinds of annual report data may be produced following the end of a firm's fiscal year: (a) Estimates of annual EPS by company officials, (b) Preliminary earnings reports, and (c) Complete annual report data. Relatively few of the companies for which preliminary and complete annual report data are published, release estimates of annual EPS made by company officials. For this reason, the number of firms in our sample is much smaller than in past studies on the stock market reaction to preliminary earnings reports [1, 3].
Routine physiotherapy does not induce a cardiorespiratory training effect post-stroke, regardless of walking ability.

BACKGROUND AND PURPOSE Cardiorespiratory fitness is increasingly being recognized as an impairment requiring physiotherapy intervention after stroke. The present study seeks to investigate if routine physiotherapy treatment is capable of inducing a cardiorespiratory training effect and if stroke patients attending physiotherapy who are unable to walk experience less cardiorespiratory stress during physiotherapy when compared to those who are able to walk. METHOD A descriptive, observational study, with heart rate monitoring and video-recording of physiotherapy rehabilitation, was conducted. Thirty consecutive stroke patients from a geriatric and rehabilitation unit of a tertiary metropolitan hospital, admitted for rehabilitation, and requiring physiotherapy were included in the study. The main measures of the study were duration (time) and intensity (percentage of heart rate reserve) of standing and walking activities during physiotherapy rehabilitation for non-walking and walking stroke patients. RESULTS Stroke patients spent an average of 21 minutes participating in standing and walking activities that were capable of inducing a cardiorespiratory training effect. Stroke patients who were able to walk spent longer in these activities during physiotherapy rehabilitation than non-walking stroke patients (p < 0.05). An average intensity of 24% heart rate reserve (HRR) during standing and walking activities was insufficient to result in a cardiorespiratory training effect, with a maximum of 35% achieved for the stroke patients able to walk and 30% for those unable to walk. CONCLUSIONS Routine physiotherapy rehabilitation had insufficient duration and intensity to result in a cardiorespiratory training effect in our group of stroke patients.