Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of saturated palmitic acid and omega-3 polyunsaturated fatty acids on Sertoli cell apoptosis

ABSTRACT Obesity is believed to negatively affect male semen quality and is accompanied by dysregulation of free fatty acid (FFA) metabolism in plasma. However, the implication of dysregulated FFA on semen quality and the involvement of Sertoli cells remain unclear. In the present study, we report obesity decreased Sertoli cell viability through dysregulated FFAs. We observed an increased rate of apoptosis in Sertoli cells, accompanied with elevated FFA levels, in the testes of obese mice that were provided a high-fat diet (HFD). Moreover, the levels of reactive oxygen species were elevated. Furthermore, we demonstrated by in vitro assays that saturated palmitic acid (PA), which is the most common saturated FFA in plasma, led to decreased cell viability of TM4 Sertoli cells in a time- and dose-dependent manner. A similar finding was noted in primary mouse Sertoli cells. In contrast to saturated FFA, omega-3 (ω-3) polyunsaturated fatty acids (PUFAs) protected Sertoli cells from PA-induced lipotoxicity at the physiologically relevant levels. These results indicated that the lipotoxicity of saturated fatty acids might be the cause of obesity-induced Sertoli cell apoptosis, which leads to decreased semen quality. In addition, ω-3 PUFAs could be classified as protective FFAs. Abbreviations: FFA: free fatty acid; HFD: high-fat diet; SD: standard diet; PA: palmitic acid; PUFA: polyunsaturated fatty acid; AI: apoptotic index; MTT: 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide; ROS: reactive oxygen species; HE: Hematoxylin and eosin; WT1: Wilm Tumor 1; NAFLD: non- alcoholic fatty liver disease; DCFH-DA: 2ʹ, 7ʹ dichloroﬂuorescin diacetate; 36B4: acidic ribosomal phosphoprotein P0; SD: standard deviation; EPA: eicosapentaenoic acid; PI: propidium iodide; DHA: docosahexenoic acid.
Molecular evolution of 5S ribosomal RNA from red and brown algae

The cytoplasmic 5S ribosomal RNA (rRNA) sequences from seven red algae, a golden-yellow alga, a diatom and five brown algae have been determined. Using these sequences, phylogenic tree of these organisms have been constructed.Three types of algae, i.e., Rhodophyta (red algae), green algae (members of green plants), and Chromophyta (brown algae, the diatom and the goldenyellow alga) are only remotely related to one another phylogenically as deduced from the 5S rRNA sequences. Red algae emerged first in the eukaryotec evolution (1.3 to 1.4 billion years ago), and thereafter various fungi, green plants including green algae and Chromophyta emerged in this order. In the red algal evolution, the so-called "primitive group" of the class Bangiophyceae and "more advanced group" of the class Florideophyceae separated first from each other in an early stage of their evolution. The tree also indicates that various red algae, such as Batrachospermum, Gelidium, Gloiopeltis and Carpopeltis are phylogenically rather remote from one another. Thus, red algae are very widely and anciently separated organisms in the evolution of eukaryotes.Chromophyta contains golden-yellow algae, diatoms and brown algae. These three groups are related to one another. During the Chromophyta evolution, the golden-yellow alga separated first, and thereafter the diatom and brown algae separated from each other. Although brown algae are very different in their morphology and life cycle, the 5S rRNA sequences clearly indicate that the brown algae were diversified quite recently within a short period.
Observers' response to facial disfigurement from head and neck cancer

Our long‐term goal is to develop a normative feedback intervention to support head and neck cancer patients in forming realistic expectations about how other people in non‐social group settings will respond to their appearance. This study aimed to evaluate the relationship between observer ratings of facial disfigurement and observer ratings of emotional response when viewing photographs of faces of head and neck cancer patients.
Prediction of Chemoresistance in Women Undergoing Neo-Adjuvant Chemotherapy for Locally Advanced Breast Cancer: Volumetric Analysis of First-Order Textural Features Extracted from Multiparametric MRI

Purpose To assess correlations between volumetric first-order texture parameters on baseline MRI and pathological response after neoadjuvant chemotherapy (NAC) for locally advanced breast cancer (BC). Materials and Methods 69 patients with locally advanced BC candidate to neoadjuvant chemotherapy underwent MRI within 4 weeks from the start of therapeutic regimen. T2, DWI, and DCE sequences were analyzed and maps were generated for Apparent Diffusion Coefficient (ADC), T2 signal intensity, and the following dynamic parameters: k-trans, peak enhancement, area under curve (AUC), time to maximal enhancement (TME), wash-in rate, and washout rate. Volumetric analysis of these parameters was performed, yielding a histogram analysis including first-order texture kinetics (percentiles, maximum value, minimum value, range, standard deviation, mean, median, mode, skewness, and kurtosis). Finally, correlations between these values and response to NAC (evaluated on the surgical specimen according to RECIST 1.1 criteria) were assessed. Results Out of 69 tumors, 33 (47.8%) achieved complete pathological response, 26 (37.7%) partial response, and 10 (14.5%) no response. Higher levels of AUCmax (p value = 0.0338), AUCrange (p value = 0.0311), and TME75 (p value = 0.0452) and lower levels of washout10 (p value = 0.0417), washout20 (p value = 0.0138), washout25 (p value = 0.0114), and washout30 (p value = 0.05) were predictive of noncomplete response. Conclusion Histogram-derived texture analysis of MRI images allows finding quantitative parameters predictive of nonresponse to NAC in women affected by locally advanced BC.
Damasio's error – Prosopagnosia with intact within‐category object recognition

The sudden inability to recognize individual faces following brain damage was first reported in a scientific journal 150 years ago and termed 'prosopagnosia' 70 years ago. While the term originally identified a face-selective neurological condition, it is now obscured by a sequence of imprecisions. First, prosopagnosia is routinely used to define symptoms of individual face recognition (IFR) difficulties in the context of visual object agnosia or other neurological conditions, or even in the normal population. Second, this over-expansive definition has lent support to a long-standing within-category recognition account of prosopagnosia, that is, that the impairment of IFR reflects a general impairment in recognizing within-category objects. However, stringent experimental studies of classical cases of prosopagnosia following brain damage show that their core impairment is not in recognizing physically similar exemplars within non-face object categories. Instead, the impairment presents specifically for recognizing exemplars of the category of faces. Moreover, compared to typical observers, the impairment appears even more severe for recognizing individual faces against physically dissimilar than similar distractors. Here, I argue that we need to limit accordingly our definition of prosopagnosia to a clinical (i.e., neurological) condition in which there is no basic-level object recognition impairment. Other criteria for prosopagnosia are proposed, with the hope that this conservative definition enables the study of human IFR processes in isolation, and supports progress in understanding the nature of these processes.
Sacrificing Accuracy for Reduced Computation: Cascaded Inference Based on Softmax Confidence

We study the tradeoff between computational effort and accuracy in a cascade of deep neural networks. During inference, early termination in the cascade is controlled by confidence levels derived directly from the softmax outputs of intermediate classifiers. The advantage of early termination is that classification is performed using less computation, thus adjusting the computational effort to the complexity of the input. Moreover, dynamic modification of confidence thresholds allow one to trade accuracy for computational effort without requiring retraining. Basing of early termination on softmax classifier outputs is justified by experimentation that demonstrates an almost linear relation between confidence levels in intermediate classifiers and accuracy. Our experimentation with architectures based on ResNet obtained the following results. (i) A speedup of 1.5 that sacrifices 1.4% accuracy with respect to the CIFAR-10 test set. (ii) A speedup of 1.19 that sacrifices 0.7% accuracy with respect to the CIFAR-100 test set. (iii) A speedup of 2.16 that sacrifices 1.4% accuracy with respect to the SVHN test set.
The impact of young maternal age at birth on neonatal mortality: Evidence from 45 low and middle income countries

Objectives This study explores the impact of early motherhood on neonatal mortality, and how this differs between countries and regions. It assesses whether the risk of neonatal mortality is greater for younger adolescent mothers compared with mothers in later adolescence, and explores if differences reflect confounding socio-economic and health care utilisation factors. It also examines how the risks differ for first or subsequent pregnancies. Methods The analysis uses 64 Demographic and Health Surveys collected between 2005 and 2015 from 45 countries to explore the relationship between adolescent motherhood (disaggregated as <16 years, 16/17 years and 18/19 years) and neonatal mortality. Both unadjusted bivariate association and logistic regression are used. Regional level multivariate models that adjust for a range of socio-economic, demographic and health service utilisation variables are estimated. Further stratified models are created to examine the excess risk for first and subsequent births separately. Findings The risk of neonatal mortality in all regions was markedly greater for infants with mothers under 16 years old, although there was marked heterogeneity in patterns between regions. Adjusting for socio-economic, demographic and health service utilisation variables did not markedly change the odds ratios associated with age. The increased risks associated with adolescent motherhood are lowest for first births. Conclusion Our findings particularly highlight the importance of reducing adolescent births among the youngest age group as a strategy for addressing the problem of neonatal mortality, as well ensuring pregnant adolescents have access to quality maternal health services to protect the health of both themselves and their infants. The regional differences in increased risk are a novel finding which requires more exploration.
Are Adolescents Engaged in the Problematic Use of Social Networking Sites More Involved in Peer Aggression and Victimization?

The problematic use of social networking sites is becoming a major public health concern. Previous research has found that adolescents who engage in a problematic use of social networking sites are likely to show maladjustment problems. However, little is known about its links with peer aggression and victimization. The main goal of this study was to analyze the relationship between problematic use of online social networking sites, peer aggression –overt vs. relational and reactive vs. instrumental–, and peer victimization –overt physical and verbal, and relational–, taking into account gender and age (in early and mid-adolescence). Participants were selected using randomized cluster sampling considering school and class as clusters. A battery of instruments was applied to 1,952 adolescents' secondary students from Spain (Andalusia) (50.4% boys), aged 11 to 16 (M = 14.07, SD = 1.39). Results showed that girls and 14–16 adolescents were more involved in a problematic use of online social networking sites. Furthermore, adolescents with high problematic use of online social networking sites were more involved in overt—reactive and instrumental—and relational—reactive and instrumental—aggressive behaviors, and self-reported higher levels of overt—physical and verbal—and relational victimization. Even though boys indicated higher levels of all types of victimization, girls with high problematic use of online social networking sites scored the highest on relational victimization. Relating to age, early adolescents (aged 11–14) with higher problematic use of online social networking sites reported the highest levels of overt verbal and relational victimization. Overall, results suggested the co-occurrence of problematic use of online social networking sites, peer aggression and victimization. In addition, results showed the influence that gender and age had on peer victimization. This study highlights the continuity between offline and online domains with regard to maladjustment problems in adolescence.
Size and Content of the Sex-Determining Region of the Y Chromosome in Dioecious Mercurialis annua, a Plant with Homomorphic Sex Chromosomes

Dioecious plants vary in whether their sex chromosomes are heteromorphic or homomorphic, but even homomorphic sex chromosomes may show divergence between homologues in the non-recombining, sex-determining region (SDR). Very little is known about the SDR of these species, which might represent particularly early stages of sex-chromosome evolution. Here, we assess the size and content of the SDR of the diploid dioecious herb Mercurialis annua, a species with homomorphic sex chromosomes and mild Y-chromosome degeneration. We used RNA sequencing (RNAseq) to identify new Y-linked markers for M. annua. Twelve of 24 transcripts showing male-specific expression in a previous experiment could be amplified by polymerase chain reaction (PCR) only from males, and are thus likely to be Y-linked. Analysis of genome-capture data from multiple populations of M. annua pointed to an additional six male-limited (and thus Y-linked) sequences. We used these markers to identify and sequence 17 sex-linked bacterial artificial chromosomes (BACs), which form 11 groups of non-overlapping sequences, covering a total sequence length of about 1.5 Mb. Content analysis of this region suggests that it is enriched for repeats, has low gene density, and contains few candidate sex-determining genes. The BACs map to a subset of the sex-linked region of the genetic map, which we estimate to be at least 14.5 Mb. This is substantially larger than estimates for other dioecious plants with homomorphic sex chromosomes, both in absolute terms and relative to their genome sizes. Our data provide a rare, high-resolution view of the homomorphic Y chromosome of a dioecious plant.
Propensity to Shop: Identifying Who Shops Til They Drop

ABSTRACT Tourist shopping expenditure is a vital ingredient which contributes significantly to the gross domestic product (GDP) of the nation. Past research has stressed the importance of specific demographic variables related to shopping behavior; however, it has not included interactions between or configurations among demographic variables, shopping related psychographics, and shopping destinations. This study seeks to address that gap. The data was collected from a large representative sample of 26,686 Australian domestic short-stay visitors. Binary logistic regression found that demographic variables and their specific interactions were significantly related to tourist shopping behaviors as well as psychographics, trip motivation, and their shopping destination propensity, when tested simultaneously. The findings assist destination marketing managers to identify and target specific domestic short-stay tourist shoppers.
Cognitive Predictors of Spoken Word Recognition in Children With and Without Developmental Language Disorders.

Purpose This study examined the influence of cognitive factors on spoken word recognition in children with developmental language disorder (DLD) and typically developing (TD) children. Method Participants included 234 children (aged 7;0-11;11 years;months), 117 with DLD and 117 TD children, propensity matched for age, gender, socioeconomic status, and maternal education. Children completed a series of standardized assessment measures, a forward gating task, a rapid automatic naming task, and a series of tasks designed to examine cognitive factors hypothesized to influence spoken word recognition including phonological working memory, updating, attention shifting, and interference inhibition. Results Spoken word recognition for both initial and final accept gate points did not differ for children with DLD and TD controls after controlling target word knowledge in both groups. The 2 groups also did not differ on measures of updating, attention switching, and interference inhibition. Despite the lack of difference on these measures, for children with DLD, attention shifting and interference inhibition were significant predictors of spoken word recognition, whereas updating and receptive vocabulary were significant predictors of speed of spoken word recognition for the children in the TD group. Conclusion Contrary to expectations, after controlling for target word knowledge, spoken word recognition did not differ for children with DLD and TD controls; however, the cognitive processing factors that influenced children's ability to recognize the target word in a stream of speech differed qualitatively for children with and without DLDs.
The price of protection: a defensive endosymbiont impairs nymph growth in the bird cherry‐oat aphid, Rhopalosiphum padi

Bacterial endosymbionts have enabled aphids to adapt to a range of stressors, but their effects in many aphid species remain to be established. The bird cherry‐oat aphid, Rhopalosiphum padi (Linnaeus), is an important pest of cereals worldwide and has been reported to form symbiotic associations with Serratia symbiotica and Sitobion miscanthi L‐type symbiont endobacteria, although the resulting aphid phenotype has not been described. This study presents the first report of R. padi infection with the facultative bacterial endosymbiont Hamiltonella defensa. Individuals of R. padi were sampled from populations in Eastern Scotland, UK, and shown to represent seven R. padi genotypes based on the size of polymorphic microsatellite markers; two of these genotypes harbored H. defensa. In parasitism assays, survival of H. defensa‐infected nymphs following attack by the parasitoid wasp Aphidius colemani (Viereck) was 5 fold higher than for uninfected nymphs. Aphid genotype was a major determinant of aphid performance on two Hordeum species, a modern cultivar of barley H. vulgare and a wild relative H. spontaneum, although aphids infected with H. defensa showed 16% lower nymph mass gain on the partially resistant wild relative compared with uninfected individuals. These findings suggest that deploying resistance traits in barley will favor the fittest R. padi genotypes, but symbiont‐infected individuals will be favored when parasitoids are abundant, although these aphids will not achieve optimal performance on a poor quality host plant.
Three Types of Broadly Reacting Antibodies against Influenza B Viruses Induced by Vaccination with Seasonal Influenza Viruses

We analyzed the antibody (Ab) repertoire against influenza B viruses induced by vaccination with seasonal influenza viruses in one individual who had never been vaccinated until 2009. The vaccine used in this study comprised B/Massachusetts/2/2012 (Yamagata lineage), A/Texas/50/2012 (H3N2), and A/California/7/2009 (H1N1). One month after the subject received two vaccinations, blood (200 ml) was obtained and peripheral mononuclear cells were prepared, and a large Ab library was constructed using phage display technology. The library was screened with HA-enriched fraction of B/Massachusetts/2/2012 and B/Brisbane/60/2008 (Victoria lineage) virus, and a total of 26 Abs that potentially bound to hemagglutinin (HA) molecules were isolated. Their binding activities to six influenza B viruses, three of Yamagata lineage and three of Victoria lineage, and two influenza A viruses, H1N1 and H3N2, were examined. The Abs showed cross-reactivity at three different levels. The first type bound to all Yamagata lineage viruses. The second type bound to both Yamagata and Victoria lineage viruses. The third type bound to both influenza A and B viruses. These results indicate that common epitopes exist on HA molecules of influenza virus at various levels, and humans have capability to produce Abs that bind to such common epitopes.
Phylogenetic Relationships of Tanaidacea (Eumalacostraca: Peracarida) Inferred from Three Molecular Loci

Abstract Molecular phylogenetic analyses were conducted on species of some common tanaidacean families within the suborders Apseudomorpha and Tanaidomorpha based on partial DNA sequences for three genes: one mitochondrial (COI) and two nuclear (H3 and 28S). One nuclear gene (28S) resolved the two suborders as monophyletic groups while H3 and COI could only resolve Tanaidomorpha as monophyletic. The total evidence analysis (in-group taxa having at least two out of the three sequences) resolved both suborders as monophyletic, but only Tanaidomorpha showed strong support. All analyses support the monophyly of Kalliapseudidae (two out of three subfamilies represented) with the family clearly separated from the other apseudomorph families represented here. Relationships between and within the other apseudomorph families could not be resolved with strong support. Within Tanaidomorpha, most analyses supported a sister group relationship between the Tanaoidea (Tanaidae) and the Paratanaoidea. Results suggested that the monotypic Hargeria should be considered a junior synonym of Leptochelia, corroborating morphological evidence. Lack of resolution is likely due to inadequate taxon sampling, and differences in topology are largely due to weak support for relationships. This is the first attempt at using molecular data to determine phylogenetic relationships of tanaidaceans.
Key Management Systems for Smart Grid Advanced Metering Infrastructure: A Survey

Smart grids are evolving as the next generation power systems that transform the traditional ways of functioning of present electrical grids. Advanced metering infrastructure (AMI) is one of the key components in smart grids. An AMI comprises of systems and networks, that are responsible for collecting and analyzing data received from smart meters. In addition, AMI also manages the different applications related with power and services based on the data collected from smart meters. Thus, AMI plays a significant role in the smooth functioning of smart grids. Malicious adversaries have immense opportunities for attacking the AMI, as it is made up of systems that are highly vulnerable to such attacks. Providing security to AMI is necessary as adversaries can cause potential infrastructural damage and privacy threats in smart grid. One of the most effective and challenging topic’s identified, is the key management system (KMS), for sustaining the security concerns in AMI. Therefore, KMS seeks to be a promising research area for future development of AMI. To the best of our knowledge, this survey is the first to highlight the significance of KMS for the security point of view for AMI in smart grids. We believe that we have taken here the needed initiatives that will help understand the importance of key management in AMI security, and strengthen future research works carried out in this area. This survey highlights the key security issues of AMIs and focuses on how key management techniques can be utilized for safeguarding AMI. At first, we discuss the main features of AMIs, the deployment scenario of smart grids and identify the relationship between smart grid and AMI. Then, we explore the main features of AMI, and also introduce the security issues and challenges. We also provide a discussion on the role of key management in AMI, and point out the differences between traditional electrical systems and smart grids. We then classify and provide a review of the existing works in literature that deal with secure KMS in AMI. Finally, we summarize the possible future open research issues and challenges of KMS in AMI.