Miracle-dz/UniFAR-FTUs huggingface dataset:
Performance evaluation of an EtherCAT master using Linux and the RT Patch

This paper has the twofold goal of investigating the real-time performance of an EtherCAT master entirely built from open-source components (using Linux and the RT Patch at the operating system level) and assess its ability to support concurrent best-effort tasks without compromising the real-time ones, depending on kernel configuration. This is especially important for the successful adoption of the proposed approach in real-world applications. A hardware-based data acquisition system enables measurements to be taken for long periods of time, and with high resolution and precision. At the same time, this method guarantees that the measurement process does not influence the behavior of the system under test in any way.
Speech-perception performance in prelingually deafened French children using the nucleus multichannel cochlear implant.

PURPOSE The speech-perception abilities of 36 French children, whose onset of deafness occurred before 2 years of age, was longitudinally examined after they received a Nucleus multichannel cochlear implant. METHODS Speech perception was assessed in four areas: phoneme detection, closed-set word and sentence recognition; and modified open-set recognition. RESULTS All children achieved phoneme detection by 3 months after implantation. Closed-set word and sentence recognition appeared initially less accurate in children with congenital deafness than in the prelingually deafened children; however, these differences disappeared by 18 months after implantation. Some modified open-set recognition was evident by 12 months after implantation and continued to improve 3 years after implantation. CONCLUSIONS Data demonstrate significant improvements in speech perception with implant experience: 15 (60%) of 25 of the children identified sentences in closed sets, 22 (88%) of 25 identified words in closed sets after 12 months' experience, and 13 (81%) of 16 demonstrated open-set recognition after 24 months of implant use.
Neuronal loss and brain atrophy in mice lacking cathepsins B and L

Cathepsins B and L are widely expressed cysteine proteases implicated in both intracellular proteolysis and extracellular matrix remodeling. However, specific roles remain to be validated in vivo. Here we show that combined deficiency of cathepsins B and L in mice is lethal during the second to fourth week of life. Cathepsin B−/−/L−/− mice reveal a degree of brain atrophy not previously seen in mice. This is because of massive apoptosis of select neurons in the cerebral cortex and the cerebellar Purkinje and granule cell layers. Neurodegeneration is accompanied by pronounced reactive astrocytosis and is preceded by an accumulation of ultrastructurally and biochemically unique lysosomal bodies in large cortical neurons and by axonal enlargements. Our data demonstrate a pivotal role for cathepsins B and L in maintenance of the central nervous system.
Limitations of Spinal Anesthesia for Patient and Surgeon During Percutaneous Nephrolithotomy.

PURPOSE To evaluate the intraoperative pain score of patients who undergo percutaneous nephrolithotomy under spinal anesthesia and to evaluate surgeons' and patients' convenience with this type of anesthesia. MATERIALS AND METHODS PCNL cases who were performed by two endourology fellows under spinal anesthesia during June to July 2014 were included. Spinal anesthesia was performed using injection of 0.25mg/kg bupivacaine 0.5% in the intrathecal space. All procedures were performed with the patient in the prone position. Stone access was made by using ? uoroscopic guidance, and the tract was dilated using a single-stage technique. Visual analogue pain score was used to assess patients' pain during operation, immediately after, and 2 hours later. RESULTS 50 patients were enrolled during the study period. Visual analogue pain score of 10 and 8 were observed in 5 and three patients respectively. In two patients the operation was terminated because of patient anxiety and pain. In another patient a second access was not obtained to remove a staghorn stone because of patient's agitation. Gross agitation was observed in six patients. Apart from flank pain, intraoperative pain was felt in the flank, scapula, abdomen and/or chest. CONCLUSION Spinal anesthesia does not provide enough analgesia for the patient in a limited frequency of percutaneous nephrolithotomy operations. We could not find statistically significant predictors of insufficient analgesiabased on patients' demographics, stone characteristics or access location.
Brain Clearance of Alzheimer's Amyloid-β40 in the Squirrel Monkey: A SPECT Study in a Primate Model of Cerebral Amyloid Angiopathy

Squirrel monkey is a valuable model to study pathogenesis of cerebrovascular amyloid angiopathy (CAA). Previous studies suggested that circulating amyloid- β 40 peptide (A β 40) crosses the blood-brain barrier (BBB) and may therefore enhance cerebrovascular amyloidosis in aged squirrel monkeys. In the present study, we used single photon emission computed tomography (SPECT) to determine elimination of 123 I-A β 40 and 99m Tc-DTPA, an extracellular marker, from the brain in squirrel monkeys at different age. Following intracerebral microinfusions, the time-activity brain clearance curves indicated bi-exponential removal of 123 I-A β 40 with an initial rapid washout (1.1 ≤ t 1/2 ≤ 2.7 h). This, plus the observed appearance of 123 I-radioactivity in plasma suggest significant brain-to-blood transport. In contrast, 99m Tc-DTPA was removed slowly by brain interstitial fluid bulk flow (monoexponential decay with 6.8 ≤ t 1/2 ≤ 16.8 h) . A comparison of three middle aged (11-16 years old) vs. two old (22 yrs old) monkeys was consistent with an age-related decline in the BBB capacity to remove 123 I-A β from the brain. This correlated with an age-dependent increase in A β 40/42 cerebrovascular immunoreactivity and amyloid deposition. Thus, vascular clearance plays an important role in reducing A β levels in the squirrel monkey brain and impaired A β 40 elimination across the BBB may contribute to the development of CAA.
Pharyngocutaneous fistula after total laryngectomy: emphasis on lymph node metastases as a new predisposing factor.

OBJECTIVE We investigated patient-related and local risk factors for pharyngocutaneous fistula developing after total laryngectomy. DESIGN Retrospective clinical study. SETTING Tertiary medical centre. METHOD The study included 255 patients who underwent total laryngectomy and concurrent neck dissection between July 2001 and February 2006 for laryngeal cancer. MAIN OUTCOME MEASURES The association of fistula and patient-related (age, sex, hemoglobin and albumin levels, diabetes mellitus, chronic obstructive pulmonary disease, chronic congestive heart disease, hypertension) and local risk factors (T stage of the tumour and localization, previous radiotherapy, preoperative tracheostomy, lymph node metastases, surgical margin) was analyzed using the chi-square and independent-sample t-tests. RESULTS Pharyngocutaneous fistulae were found in 18.4% of the patients. Lymph node metastases, chronic congestive heart disease, and postoperative hemoglobin and albumin levels lower than 10.84 +/- 1.2 g/dL and 3.06 +/- 0.5 g/dL, respectively, were found to be statistically significant risk factors in fistula formation. The logistic regression model was carried out on these risk factors. CONCLUSION Pharyngocutaneous fistula remains the most frequent complication of total laryngectomy despite improved preoperative assessment and postoperative care. Lymph node metastases emerged for the first time as a risk factor for fistula formation. Our experience confirmed that meticulous postoperative care should be paid to the patients who have contributing risk factors and lymph node metastases.
Humour therapy in patients with late‐life depression or Alzheimer's disease: a pilot study

Of the disabling disorders of the elderly, depression is the most common affective disorder and Alzheimer's disease (AD) the most common neurodegenerative disorder. Pharmacological treatment strategies for these disorders are often accompanied with severe side effects. Therefore non‐pharmacological treatment strategies are of great importance. The aim of the present study was to investigate the impact of humour therapy on quality of life in patients with depression or AD.
Sterols and sphingolipids strongly affect the growth of fusion pores induced by the hemagglutinin of influenza virus.

Cells expressing the hemagglutinin (HA) of influenza virus were fused to planar phospholipid bilayer membranes to evaluate the effects of sterols and sphingolipids in the target bilayer membranes on properties of fusion pores. Typically, in the absence of sterol, flickering pores are observed, followed by a successful pore (i.e., a pore that fully opens). The incorporation of cholesterol into the lipid bilayer had a marked effect: it greatly decreased the number of flickers, and the first pore formed was usually successful. Similar effects were produced by the sterols epicholesterol and 5beta-cholestanol. In contrast, the sterols cholesteryl acetate, coprostanol, and stanolone did not affect pore flickering, and a successful pore was observed to follow the typical number of flickers. 5alpha-cholestanol gave intermediate results. From these results, it follows that the 3-OH of cholesterol is essential to reduce flickering, but it does not matter if the 3-OH is in an alpha or beta configuration. The double bond is also not critical for the actions of cholesterol nor is the fact that it is a flat molecule. The sphingolipids sphingomyelin, lactosyl cerebroside, and glucosyl cerebroside tended to inhibit full pore enlargement, prolonging the stage of pore flickering. If a sphingolipid and a sterol that strongly interact were both included in the planar membrane, the pattern of flickering was the same as if neither had been included in the bilayer. However, if a sphingolipid and sterol that do not interact with each other were included in the bilayer, the reduced flickering characteristic of the sterol was observed.
Dynamics of Low-Fee Private Schools in Kenya: Governmental Legitimation, School-Community Dependence, and Resource Uncertainty

Background/Context The UN Sustainable Development Goals include a renewed commitment to inclusive and equitable education for all and will maintain pressure on governments in low-income countries to ensure this provision. A range of prominent researchers and institutional actors continue to explore and to promote low-fee private schools (LFPSs) as a viable option for achieving universal access to basic education. The emphasis on LFPSs can be seen as part of the push for education policies that attempt to improve educational access and quality not through the strengthening of public education but through the establishment of public–private partnerships. Focus of Study In this paper we explore the Kenyan government's engagement with LFPSs, document and assess the impact of this support on the behavior of LFPS and clarify key actor perspectives and responses within this context. Research Design Through a qualitative case study of two LFPSs in a large urban informal settlement near Nairobi, we focus on the dynamic interaction and delicate equilibrium within which government officials, LFPS representatives, parents, and students not only interact with but influence each other. Data for the study were gathered over the course of 8 weeks during May and June of 2010 in the urban slum called Mathare Village in Nairobi through document review, 35 interviews, and school visits. Conclusions The findings suggest that LFPSs do not function in practice as in theory, and crucially, that there are inherent trade-offs, tensions, and unexpected dynamics in operation that have serious consequences for such issues as quality and equity, even when supported by formal government policy designed to address these aspects. The study reinforces the importance of national governments and international bodies increasing the resources devoted to improving access to, and the quality of, public education.
Longitudinal changes and predictors of prolonged grief for bereaved family caregivers over the first 2 years after the terminally ill cancer patient’s death

Background: A significant minority of bereaved caregivers experience prolonged grief. However, few longitudinal studies have examined prolonged grief, especially in an Asian context. Aim: We explored longitudinal changes and factors predicting prolonged grief in bereaved caregivers of terminally ill Taiwanese cancer patients. Design: Observational, prospective, and longitudinal. Prolonged grief symptoms were measured with the PG-13 at 6, 13, 18, and 24 months postloss. Setting/participants: A convenience sample of 493 caregivers (83.3% participation rate) of terminally ill cancer patients was recruited from a medical center in Taiwan. Results: The prevalence of prolonged grief decreased significantly over time from the patient’s death (7.73%, 1.80%, 2.49%, and 1.85% at 6, 13, 18, and 24 months postloss, respectively, p < 0.05 at all times in reference to 6 months postloss). Caregivers’ likelihood of prolonged grief was significantly higher if they had severe preloss depressive symptoms, negatively perceived their relative’s dying situation, and were poorly prepared for the patient’s death. However, the likelihood of prolonged grief decreased significantly with greater perceived concurrent social support and subjective caregiving burden right before the patient’s death. Conclusion: Prolonged grief in bereavement diminished over time and was predicted by modifiable factors before, during, and after bereavement. To facilitate bereavement adjustment and avoid prolonged grief, healthcare professionals should develop and provide at-risk caregivers with effective interventions starting when patients are still alive to improve their dying experience, to facilitate preparedness for the patient’s forthcoming death, to alleviate caregivers’ preloss depressive symptoms, and to enhance their perceived postloss social support.
New experimental findings on hot carrier effects in sub-0.1 μm MOSFET's

The behaviors of the substrate current and the impact ionization rate are investigated for deep submicron devices in a wide temperature range. New important features are shown for the variations of the maximum substrate current as a function of applied biases and temperature. It is found that the gate voltage V/sub gmax/, corresponding to the maximum impact ionization current conditions, is quasi-constant as a Function of the drain bias for sub-0.1 /spl mu/m MOSFET's in the room temperature range. At low temperature, a substantial increase of V/sub gmax/ is observed when the drain voltage is reduced. It is also shown that, although a significant enhancement of hot carrier effects is observed by scaling down the devices, a strong reduction of the impact ionization rate is obtained for sub-0.1 /spl mu/m MOSFET's operated at liquid nitrogen temperature in the low drain voltage range. <<ETX>>
Navigating the pitfalls and promise of landscape genetics

The field of landscape genetics has been evolving rapidly since its emergence in the early 2000s. New applications, techniques and criticisms of techniques appear like clockwork with each new journal issue. The developments are an encouraging, and at times bewildering, sign of progress in an exciting new field of study. However, we suggest that the rapid expansion of landscape genetics has belied important flaws in the development of the field, and we add an air of caution to this breakneck pace of expansion. Specifically, landscape genetic studies often lose sight of the fundamental principles and complex consequences of gene flow, instead favouring simplistic interpretations and broad inferences not necessarily warranted by the data. Here, we describe common pitfalls that characterize such studies, and provide practical guidance to improve landscape genetic investigation, with careful consideration of inferential limits, scale, replication, and the ecological and evolutionary context of spatial genetic patterns. Ultimately, the utility of landscape genetics will depend on translating the relationship between gene flow and landscape features into an understanding of long‐term population outcomes. We hope the perspective presented here will steer landscape genetics down a more scientifically sound and productive path, garnering a field that is as informative in the future as it is popular now.
Phylogenetic Positions of Insectivora in Eutheria Inferred from Mitochondrial Cytochrome c Oxidase Subunit II Gene

Abstract For the elucidation of the phylogenetic position of insectivora in eutheria, we have sequenced the cytochrome c oxidase subunit II (COII) gene of mitochondria for three insectivoran species [musk shrew (Suncus murinus), shrew mole (Urotrichus talpoides), Japanese mole (Mogera wogura)] and analyzed these amino acid sequences with neighbor-joining (NJ) method and maximum likelihood (ML) method. NJ analysis shows polyphyly of Insectivora and Chiroptera. Assuming that each of Primates, Ferungulata, Chiroptera, Insectivora and Rodentia is a monophyletic group, ML analysis suggests that Chiroptera is a sister group of Insectivora and that Ferungulata is the closest outgroup to the (Insectivora and Chiroptera) clade.
Effect of carrier tunneling on the structure of Si nanowires fabricated by metal assisted etching

The metal assisted etching mechanism for Si nanowire fabrication, triggered by doping type and level and coupled with choice of metal catalyst, is still very poorly understood. We explain the different etching rates and porosities of wires we observe based on extensive experimental data, using a new empirical model we have developed. We establish as a key parameter, the tunneling through the space charge region (SCR) which is the result of the reduction of the SCR width by level of the Si wafer doping in the presence of the opposite biases of the p- and n-type wafers. This improved understanding should permit the fabrication of high quality wires with predesigned structural characteristics, which hitherto has not been possible.
Cortical development in the presenilin‐1 null mutant mouse fails after splitting of the preplate and is not due to a failure of reelin‐dependent signaling

Cortical development is disrupted in presenilin‐1 null mutant (Psen1−/−) mice. Prior studies have commented on similarities between Psen1−/− and reeler mice. Reelin induces phosphorylation of Dab1 and activates the phosphatidylinositol 3‐kinase (PI3K)/Akt pathway. Psen1 is known to modulate PI3K/Akt signaling and both known reelin receptors (apoER2 and VLDLR) are substrates for Psen1 associated γ‐secretase activity. The purpose of this study was to determine whether reelin signaling is disrupted in Psen1−/− mice. We show that, while Dab1 is hypophosphorylated late in cortical development in Psen1−/− mice, it is normally phosphorylated at earlier ages and reelin signaling is intact in Psen1−/− primary neuronal cultures. γ‐secretase activity was also not required for reelin‐induced phosphorylation of Dab1. Unlike reeler mice the preplate splits in Psen1−/− brain. Thus cortical development in Psen1−/− mice fails only after splitting of the preplate and is not due to an intrinsic failure of reelin signaling. Developmental Dynamics 237:2405–2414, 2008. © 2008 Wiley‐Liss, Inc.
The influence of corporate governance on corporate performance: evidence from Palestine

The objective of this study is to explore the relationship between corporate performance and corporate governance by companies listed on the Palestinian Stock Exchange. Accounting and market performance measures were used to proxy corporate performance. Corporate governance represented by the board of directors' size, the frequency of the annual meetings of the board, existence or otherwise of an audit committee, institutional investors ownership and foreign ownership. To achieve the objective of the study, all non-financial companies listed on the exchange and published their annual reports during the period between 2010 and 2012 were used. The result of the analysis revealed that corporate performance is negatively associated with corporate governance. This implies that the result is inconsistent with agency theory. This might be due to the fact that corporate governance in Palestine is still at its infancy stage.
Neuromorphometry of primary brain tumors by magnetic resonance imaging

Abstract. Magnetic resonance imaging is a technique for the diagnosis and classification of brain tumors. Discrete compactness is a morphological feature of two-dimensional and three-dimensional objects. This measure determines the compactness of a discretized object depending on the sum of the areas of the connected voxels and has been used for understanding the morphology of nonbrain tumors. We hypothesized that regarding brain tumors, we may improve the malignancy grade classification. We analyzed the values in 20 patients with different subtypes of primary brain tumors: astrocytoma, oligodendroglioma, and glioblastoma multiforme subdivided into the contrast-enhanced and the necrotic tumor regions. The preliminary results show an inverse relationship between the compactness value and the malignancy grade of gliomas. Astrocytomas exhibit a mean of 973±14, whereas oligodendrogliomas exhibit a mean of 942±21. In contrast, the contrast-enhanced region of the glioblastoma presented a mean of 919±43, and the necrotic region presented a mean of 869±66. However, the volume and area of the enclosing surface did not show a relationship with the malignancy grade of the gliomas. Discrete compactness appears to be a stable characteristic between primary brain tumors of different malignancy grades, because similar values were obtained from different patients with the same type of tumor.
Injury risk is altered by previous injury: a systematic review of the literature and presentation of causative neuromuscular factors.

BACKGROUND Active adults commonly present with lower extremity (LE) injuries from a variety of professional and amateur sports activities. Decreased LE function significantly alters daily life and subsequent injuries increase this impact. The purpose of this systematic review was to examine the association between previous injury and the risk of re-injury, and to describe the changes in kinematics and motor programming that may contribute to this relationship. METHODS A preliminary search was conducted to determine the four most common LE injuries on PubMed, CINAHL and Web of Science. These injuries, in a healthy active adult population, were hamstring strain (HS), anterior cruciate ligament injury (ACL), achilles tendon pathology, and ankle sprain. After these injuries were established, the search for this systematic review found evidence relating these injuries to re-injury. Articles related to degenerative changes were excluded. Twenty-six articles were included in the systematic review detailing the risk of re-injury from a previous injury and were graded for quality. RESULTS ACL injury was linked to a successive injury of the same ACL, and other injuries in the LE. HS was associated with subsequent ipsilateral HS and knee injuries. Previous achilles tendon rupture increased the risk of an analogous injury on the contralateral side. An ankle sprain was associated with a re-injury of either the ipsilateral or the contralateral ankle. Post-injury changes were present in strength, proprioception, and kinematics, which may have led to overall changes in motor control and function. CONCLUSION This review provides insight into the changes occurring following common LE injuries, how these changes potentially affect risk for future injury, and address the needs of the active adult population in rehabilitation. CLINICAL RELEVANCE Current research on previous injury and re-injury is of high quality, but scarce quantity. Deficits following an injury are known, but how these deficits correlate or lead to re-injury requires further exploration. LEVEL OF EVIDENCE 1.