Miracle-dz/UniFAR-FTUs huggingface dataset:
IDENTIFICATION OF SUNFLOWER (Helianthus annus L.) SALT TOLERANT GENOTYPES

Salinity is one of the major problems limiting the crop production including oil seeds. The reclamation of these saline soils are expensive and time consuming. As agricultural crops and their varieties differ considerably with regard to salt-tolerance, study of salt genotypes seems promissing. Keeping in view, a greenhouse experiment was carried out for the identification of salt tolerant genotypes of sunflower, as well as their characteristics. Nine genotypes were grown in aerated Hoagland’s nutrient solution. Three salinity levels 40, 80 and 120 mol m-3 were artificially maintained with the help of commercial NaCl.Wheras, control contained Hoagland’s nutrient solution only. Results showed that shoot length decreased significantly with increase in salinity and maximum shoot length was found in SH-3322 while, the minimum in QPS-1001 at 40,80 and 120 mol m-3 level. Maximum root length was found in SH-3322 at all levels. Shoot fresh weight, shoot dry weight, root fresh weight and root dry weight decreased significantly with increased salinity. The maximum Na+ concentration was recorded for ICI-HYSUN-33. while minimum was observed for SH-3322 and SF-187 in all salinity levels. On an overall basis SH-3322 was proved to be the best in saline soil. Key words: salinity, sunflower, salt tolerant genotype, oil seeds, reclamation.
Financial Contracting and Concentration of Operational Control

Concentration of operational control can make it easier for a manager to operate more efficiently but can also make it easier for the manager to act in self interest counter to efficiency. This paper presents a stylized intertemporal model comparing two institutional arrangements, one with concentrated control and one with dispersed control. With concentrated control, the manager who chooses costly effort also controls the incoming cash flows, while with dispersed control the incoming cash flows are controlled by an investor, not the manager. The two arrangements create different potential incentive problems. With concentrated control, the manager may take the entire cash flow out of the firm and with dispersed control, the manager may expend too little effort. Depending on the relative severity of the two incentive problems, either arrangement may dominate. The incentive problems are exacerbated if there is an aftermarket in the firm’s assets and are reduced by gradual buyout of initial investment, compensation in ownership and non-vested pensions.
Impact of Disease and Treatment Response in Drug–Drug Interaction Studies: Osimertinib and Simvastatin in Advanced Non‐Small Cell Lung Cancer

A phase I, open‐label study (NCT02197234) assessed the effects of osimertinib on simvastatin exposure in patients with advanced epidermal growth factor receptor (EGFR)‐mutated non‐small cell lung cancer and disease progression post‐EGFR tyrosine kinase inhibitor treatment. Here, we report on a retrospective analysis of two patients (patients 1 and 2) who had liver metastases and high simvastatin exposure prior to osimertinib treatment, which changed following treatment. Patients received single oral doses of simvastatin 40 mg on day (D) 1 and D31, and osimertinib 80 mg once daily on D3–32. At baseline, both patients had abnormal liver function tests (LFTs; Child‐Pugh scores of 6 and 8, respectively), significant liver metastasis, and, after a single simvastatin dose, had higher (~ 10‐fold) exposure compared with all other patients. Following 31 days of continuous osimertinib treatment, simvastatin exposures (area under the plasma concentration‐time curve from zero to infinity (AUC) and maximum plasma concentration (Cmax)) and LFTs, such as alanine transaminase, aspartate aminotransferase, and bilirubin normalized to population mean values. Additionally, ~ 50% and ~ 80% reductions in liver metastases were observed on computed tomography scans in patients 1 and 2, respectively. High simvastatin exposure on D1 likely resulted from impairment of hepatic first pass metabolism due to liver metastases. Reduction in hepatic disease burden due to osimertinib treatment likely resulted in liver function returning to normal levels.
OWNERSHIP TYPE INFLUENCE ON DIVIDEND PAYMENTS IN CEE COUNTRIES

The present paper provides practical implications for the Central and Eastern European equity investors, who seek dividend income in addition to the capital appreciation. The insight into the dividend puzzle in the CEE companies, provided in the research, gives an overview of the dividend yields and payment stability as well as the relationship between the dividend payments and the type of ownership. Main findings of the study prove that the highest yield and the highest payout ratio are obtained in the case of strategic investor acting as a major shareholder (>10% of ownership capital). Binary logistic regression results provide the possibility to forecast whether the company will pay dividends. The typical dividend payer should not have family/management as a major investor, the ownership still should be concentrated and the investor preferably should be of local origin.
Mapping quantitative trait loci controlling low-temperature germinability in rice

Low-temperature germination is one of the major determinants for stable stand establishment in the rice direct seeding method in temperate regions and at high altitude areas. Quantitative trait loci (QTL) controlling low-temperature germinability in rice were identified using 96 introgression lines (ILs) derived from a cross between Oryza rufipogon and the Korean japonica cultivar, ‘Hwaseongbyeo’. The germination rate at 15℃ was measured to represent low-temperature germination and used for QTL analysis. The germination rate at 15℃ for 7 days of Oryza rufipogon and Hwaseongbyeo was 93.3 and 28.7%, respectively, and that of progenies ranged from 0 to 48%. A linkage map was constructed using 135 simple sequence repeat (SSR) markers. Five putative QTLs associated with low-temperature germination were detected on chromosomes 1, 3, 4, 10 and 11. The QTL, qltg10 on chromosome 10 accounted for 19.2% of the total phenotypic variation for low-temperature germinability. Four additional QTL, accounted for 10.4 - 15.1% of the total phenotypic variation. The O. rufipogon alleles in all detected QTLs loci increased the low-temperature germination rate. No QTL associated with low temperature germinability has been detected near the qltg10 QTL in this study suggesting that qltg10 is a new QTL. The locus, qltg10 is of particular interest because of its independence from undesirable height and maturity effects. The DNA markers linked to the QTL for low temperature germinability would be useful in selecting lines with enhanced low temperature germinability in rice breeding program.
Representation of Mental Illness in Leading Ugandan Daily Newspapers: A Content Analysis

ABSTRACT Media are a major purveyor of information about mental health. Recognizing what messages media are disseminating about mental illness, therefore, is a step toward raising mental health literacy in a population. Most research about media coverage of mental illness, however, has taken place in Western nations. Differences in cultural views of mental illness and severely strained mental health-care resources in sub-Saharan African make it likely that media coverage of mental illness there will differ substantially from Western contexts. This study investigated the coverage of mental illness in the two largest circulation newspapers in Uganda: The Monitor and The New Vision. Analysis of the entire contents of every issue of both papers from January 1, 2017 to June 30, 2019 revealed just 53 articles addressing mental illness. Although types of mental illness addressed did not differ greatly from coverage in Western newspapers, causes to which mental illness was attributed included war, poverty, and witchcraft, none of which appears in content analyses in other contexts. Also, different than Western media, most articles were thematically rather than episodically framed, especially in the government-owned paper, and individuals with mental illness themselves were regularly cited.
A Deep One-Class Neural Network for Anomalous Event Detection in Complex Scenes

How to build a generic deep one-class (DeepOC) model to solve one-class classification problems for anomaly detection, such as anomalous event detection in complex scenes? The characteristics of existing one-class labels lead to a dilemma: it is hard to directly use a multiple classifier based on deep neural networks to solve one-class classification problems. Therefore, in this article, we propose a novel DeepOC neural network, termed as DeepOC, which can simultaneously learn compact feature representations and train a DeepOC classifier. Only with the given normal samples, we use the stacked convolutional encoder to generate their low-dimensional high-level features and train a one-class classifier to make these features as compact as possible. Meanwhile, for the sake of the correct mapping relation and the feature representations’ diversity, we utilize a decoder in order to reconstruct raw samples from these low-dimensional feature representations. This structure is gradually established using an adversarial mechanism during the training stage. This mechanism is the key to our model. It organically combines two seemingly contradictory components and allows them to take advantage of each other, thus making the model robust and effective. Unlike methods that use handcrafted features or those that are separated into two stages (extracting features and training classifiers), DeepOC is a one-stage model using reliable features that are automatically extracted by neural networks. Experiments on various benchmark data sets show that DeepOC is feasible and achieves the state-of-the-art anomaly detection results compared with a dozen existing methods.
MicroRNA‐96 is a potential tumor repressor by inhibiting NPTX2 in renal cell carcinoma

MicroRNA‐96 (miR‐96) is a vertebrate conserved microRNA which plays important roles in various cancers including renal cell carcinoma (RCC). However, its function and mechanism in RCC are still unclear. In this study, miR‐96 was found to be downregulated in RCC based on The Cancer Genome Atlas datasets analyses, and its target genes, which predicted by TargetScan, were investigated. Among these target genes, neuronal pentraxin 2 (NPTX2) was upregulated more than 15‐fold in RCC, and moreover, closely related to patient survival. To validate its targeting of NPTX2 experimentally, reverse transcription polymerase chain reaction, Western blot analysis, and dual‐luciferase assays were performed, and results of these assays demonstrated that miR‐96 inhibited expression of NPTX2 through a single 3′‐untranslated region targeting site. Furthermore, transfection assays in RenCa and 786‐O cells showed miR‐96 and small interfering RNA of NPTX2 inhibited cell proliferation, migration, and invasion and overexpression of NPTX2 recovered the inhibition of miR‐96. In conclusion, the present study reveals a novel regulatory mechanism of miR‐96 on NPTX2 expression in RCC, and the potential of miR‐96 as a RCC tumor repressor deserves further investigation.
CO2 reutilization for methane production via a catalytic process promoted by hydrides.

CO2 emissions have been continuously increasing during the last half of the century with a relevant impact on the planet and are the main contributor to the greenhouse effect and global warming. The development of new technologies to mitigate these emissions poses a challenge. Herein, the recycling of CO2 to produce CH4 selectively by using Mg2FeH6 and Mg2NiH4 complex hydrides as dual conversion promoters and hydrogen sources has been demonstrated. Magnesium-based metal hydrides containing Fe and Ni catalyzed the hydrogenation of CO2 and their total conversion was obtained at 400 °C after 5 h and 10 h, respectively. The complete hydrogenation of CO2 depended on the complex hydride, H2 : CO2 mol ratio, and experimental conditions: temperature and time. For both hydrides, the activation of CO2 on the metal surface and its subsequent capture resulted in the formation of MgO. Investigations on the Mg2FeH6-CO2 system indicated that the main process occurs via the reversed water-gas shift reaction (WGSR), followed by the methanation of CO in the presence of steam. In contrast, the reduction of CO2 by the Mg-based hydride in the Mg2NiH4-CO2 system has a strong contribution to the global process. Complex metal hydrides are promising dual promoter-hydrogen sources for CO2 recycling and conversion into valuable fuels such as CH4.
Characterisation of concurrent use of prescription opioids and benzodiazepine/Z-drugs in Alberta, Canada: a population-based study

Objective The objective of this study is to characterise concurrent use of benzodiazepine receptor modulators and opioids among prescription opioid users in Alberta in 2017. Design A population based retrospective study. Setting Alberta, Canada, in the year 2017. Participants All individuals in Alberta, Canada, with at least one dispensation record from a community pharmacy for an opioid in the year 2017. Exposure Concurrent use of a benzodiazepine receptor modulator and opioid, defined as overlap of supply for both drugs for at least 1 day. Main outcome measures Prevalence of concurrency was estimated among subgroups of patient characteristics that were considered clinically relevant or associated with inappropriate medication use. Results Among the 547 709 Albertans who were dispensed opioid prescriptions in 2017, 132 156 (24%) also received prescriptions for benzodiazepine receptor modulators. There were 96 581 (17.6%) prescription opioid users who concurrently used benzodiazepine receptor modulators with an average of 98 days (SD=114, 95% CI 97 to 99) of total cumulative concurrency and a median of 37 days (IQR 10 to 171). The average longest duration of consecutive days of concurrency was 45 (SD=60, 95% CI 44.6 to 45.4) with a median of 24 days (IQR 8 to 59). Concurrency was more prevalent in females, patients using an average daily oral morphine equivalent >90 mg, opioid dependence therapy patients, chronic opioid users, patients utilising a high number of unique providers, lower median household incomes and those older than 65 (p value<0.001 for all comparisons). Conclusions Concurrent prescribing of opioids and benzodiazepine receptor modulators is common in Alberta despite the ongoing guidance of many clinical resources. Older patients, those taking higher doses of opioids, and for longer durations may be at particular risk of adverse outcomes and may be worthy of closer follow-up for assessment for dose tapering or discontinuations. As well, those with higher healthcare utilisation (seeking multiple providers) should also be closely monitored. Continued surveillance of concurrent use of these medications is warranted to ensure that safe drug use recommendations are being followed by health providers.
Homozygous missense variant in BMPR1A resulting in BMPR signaling disruption and syndromic features

The bone morphogenetic protein (BMP) pathway is known to play an imperative role in bone, cartilage, and cardiac tissue formation. Truncating, heterozygous variants, and deletions of one of the essential receptors in this pathway, Bone Morphogenetic Protein Receptor Type1A (BMPR1A), have been associated with autosomal dominant juvenile polyposis. Heterozygous deletions have also been associated with cardiac and minor skeletal anomalies. Populations with atrioventricular septal defects are enriched for rare missense BMPR1A variants.
Has the threshold for revision surgery for adverse reactions to metal debris changed in metal-on-metal hip arthroplasty patients? A cohort study of 239 patients using an adapted risk-stratification algorithm

Background and purpose — A risk-stratification algorithm for metal-on-metal hip arthroplasty (MoMHA) patients was devised by US experts to help clinicians make management decisions. However, the proposed algorithm did not cover all potential patient or surgical abnormalities. Therefore we adapted the US risk-stratification algorithm in MoMHA patients revised for adverse reactions to metal debris (ARMD) to determine the variability in the revision threshold, and also whether high-risk patients had inferior outcomes following revision. Patients and methods — We analysed 239 MoMHA revisions for ARMD between 2001 and 2016 from 2 centres with pre-revision blood metal ions and imaging. Patients were stratified (low risk, moderate risk, high risk) using pre-revision factors (implant, radiographic, blood metal ions, cross-sectional imaging) by adapting a published algorithm. The risk categories for each factor were assessed against revision year, revision centre, and post-revision outcomes (re-revision surgery, and any poor outcome). Results — Compared with hips revised before 2012, hips revised from 2012 onwards included more high-risk implants (44% vs. 17% pre-2012), high-risk radiographic features (85% vs. 69% pre-2012), and low-risk metal ions (41% vs. 19% pre-2012). 1 centre more frequently revised patients with high-risk implants (48% vs. 14%) and low-risk blood metal ions (45% vs. 15%) compared with the other. All these comparisons were statistically significant (p < 0.05). With the limited sample size available, implant, radiographic, blood metal ion, and cross-sectional imaging risk groups did not statistically significantly affect the rates of re-revision surgery or frequency of poor outcomes post-revision. Interpretation — When applying the adapted risk-stratification algorithm the threshold for ARMD revision changed over time, presumably due to increasing evidence, patient surveillance, and investigation since 2012. Lower blood metal ion thresholds were used from 2012 for ARMD revisions; however, there was evidence that centres attached different importance to metal ions when managing patients. High-risk patients did not have inferior outcomes following ARMD revision.
Response of Yield and Yield Components of Three Red Bean (Phaseolus vulgaris L.) Genotypes to Co-Inoculation with Glomus intraradices and Rhizobium phaseoli

The use of biotechnology with the aim of using soil beneficial organisms to produce maximum production, improving soil quality and considering hygiene and environmental safety, has been considered. In order to investigate the effect of biological fertilizers on beans yield and yield components, a field study was conducted during spring and summer 2010 in agricultural experimental station of Arak Islamic Azad University. A factorial experiment was arranged in randomized complete block design with three replication. Three beans varieties Goli (indeterminate), Sayad (Semi determinate) and Derakhshan (determinate) were used. Mycorrhiza fungi including no inoculation and Glomus intraradices and three levels of Rhizobium phaseoli (no application, strain Rb116 and strain Rb133) were used. Interaction between Mycorrhiza, Rhizobium and cultivars on yield and yield components showed highest seed yield (2664 kg ha ) and biological yield (6333 kg ha ) 11 in treatment of inoculation Goli variety with both mycorrhiza (Glomus intarardices) and Rhizobium strain Rb133, respectively. The lowest yield (1172 kg ha ) was obtained in treatment not using Mycorrhiza fungi and 1 Rhizobium bacteria with variety Derakhshan.
Patterns of Cocaine Use During Treatment: Associations With Baseline Characteristics and Follow-Up Functioning.

OBJECTIVE Abstinence outcomes are typically prioritized in the treatment of cocaine use disorder while ignoring patterns of low-frequency cocaine use. This study examined patterns of cocaine use frequency during treatment and evaluated how these patterns related to baseline characteristics and functioning outcomes 6 and 12 months after treatment. METHOD We used a pooled dataset (N = 720) from seven randomized clinical trials for cocaine use disorder. The Addiction Severity Index (ASI) was used to assess functioning. Repeated-measures latent class analysis was used to derive patterns of cocaine use. RESULTS Three patterns were identified: abstinence (10.6%), low-frequency use (approximately 1 day/week; 66.3%), and persistent frequent use (approximately 4 days/week; 23.1%). The low-frequency group was associated with male gender, younger age, and a criminal justice referral. The abstinent group had the highest alcohol problem severity score at baseline. At Month 6, the low-frequency group reported lower problem severity than the persistent frequent use group across multiple ASI areas, including the cocaine use as well as psychological, family, employment, and legal domains. At Month 12, the low-frequency group did not differ from the abstinent group in problem severity on any ASI domain and, relative to the persistent frequent use group, had lower cocaine use and employment problem severity. CONCLUSIONS These findings highlight the importance of adopting a harm reduction approach and recognizing the potential clinical benefits associated with nonabstinent outcomes.
The efficacy of app‐supported smartphone interventions for mental health problems: a meta‐analysis of randomized controlled trials

Although impressive progress has been made toward developing empirically‐supported psychological treatments, the reality remains that a significant proportion of people with mental health problems do not receive these treatments. Finding ways to reduce this treatment gap is crucial. Since app‐supported smartphone interventions are touted as a possible solution, access to up‐to‐date guidance around the evidence base and clinical utility of these interventions is needed. We conducted a meta‐analysis of 66 randomized controlled trials of app‐supported smartphone interventions for mental health problems. Smartphone interventions significantly outperformed control conditions in improving depressive (g=0.28, n=54) and generalized anxiety (g=0.30, n=39) symptoms, stress levels (g=0.35, n=27), quality of life (g=0.35, n=43), general psychiatric distress (g=0.40, n=12), social anxiety symptoms (g=0.58, n=6), and positive affect (g=0.44, n=6), with most effects being robust even after adjusting for various possible biasing factors (type of control condition, risk of bias rating). Smartphone interventions conferred no significant benefit over control conditions on panic symptoms (g=–0.05, n=3), post‐traumatic stress symptoms (g=0.18, n=4), and negative affect (g=–0.08, n=5). Studies that delivered a cognitive behavior therapy (CBT)‐based app and offered professional guidance and reminders to engage produced larger effects on multiple outcomes. Smartphone interventions did not differ significantly from active interventions (face‐to‐face, computerized treatment), although the number of studies was low (n≤13). The efficacy of app‐supported smartphone interventions for common mental health problems was thus confirmed. Although mental health apps are not intended to replace professional clinical services, the present findings highlight the potential of apps to serve as a cost‐effective, easily accessible, and low intensity intervention for those who cannot receive standard psychological treatment.