Miracle-dz/UniFAR-FTUs huggingface dataset:
Abnormal Platelet Trace Amine Profiles in Migraine With and Without Aura

Trace amines, including tyramine, octopamine and synephrine, are closely related to classic biogenic amines. In one study, where these substances were found elevated in plasma of migraineurs, it was hypothesized that trace amine metabolism is deranged in migraine. To confirm these findings, we studied, using a multichannel electrochemical high-performance liquid chromatography system, the concentrations of trace amines in platelets of migraine without aura (MoA) and migraine with aura (MA) patients in headache-free period, compared with controls. Platelet concentrations of trace amines, although elevated in both migraine types, showed a different profile in MoA and MA. Octopamine was significantly higher in MoA sufferers (0.69 ± 0.43 ng/108 platelets) compared with both control subjects (0.22 ± 0.16 ng/108 platelets) and MA patients (0.39 ± 0.37 ng/108 platelets). Synephrine was significantly higher in MA patients (0.72 ± 0.44 ng/108 platelets) with respect to both controls (0.33 ± 0.25 ng/108 platelets) and MoA sufferers (0.37 ± 0.29 ng/108 platelets). These results strengthen the hypothesis that tyrosine metabolism is deranged in migraine and may participate in its pathophysiology.
The Histologic Features of Hyperplastic Lymphadenopathy in AIDS-Related Complex are Nonspecific

AbstractFollicular hyperplasia is the most common histologic finding in lymph nodes of patients with AIDS-related complex (ARC) and persistent generalized lymphadenopathy. To determine the specificity of the published features considered characteristic of this condition, we compared two sets of lymph-node biopsy specimens with follicular hyperplasia. Thirty-eight specimens were from human immunodeficiency virus (HIV/HTLV3/LAV) positive homosexual men with persistent generalized lymphadenopathy, and 87 specimens were from patients free of AIDS risk. Polykaryocytes, epithelioid histiocytes, and follicle mantle zone effacement were significantly more common in the ARC group. Dermatopathic change and so-called follicle lysis were significantly more common in control, non-ARC nodes. No statistically significant difference between the two groups could be demonstrated for the following features: irregularity of follicles, burnt-out follicles, sinus monocytoid cells, marked plasmacytosis, and the toxoplasmosis triad. Most importantly, no feature was seen exclusively in either of the two groups. Although some features considered characteristic of the hyperplastic form of ARC lymphadenopathy are seen more commonly in this condition than in lymph nodes showing follicular hyperplasia unrelated to ARC, none of these features is specific for ARC and there is no histologic picture diagnostic of this condition.
Virtual Network Embedding: A Hybrid Vertex Mapping Solution for Dynamic Resource Allocation

Virtual network embedding (VNE) is a key area in network virtualization, and the overall purpose of VNE is to map virtual networks onto an underlying physical network referred to as a substrate. Typically, the virtual networks have certain demands, such as resource requirements, that need to be satisfied by the mapping process. A virtual network (VN) can be described in terms of vertices (nodes) and edges (links) with certain resource requirements, and, to embed a VN, substrate resources are assigned to these vertices and edges. Substrate networks have finite resources and utilizing them efficiently is an important objective for a VNE method. This paper analyzes two existing vertex mapping approaches--one which only considers if enough node resources are available for the current VN mapping and one which considers to what degree a node already is utilized by existing VN embeddings before doing the vertex mapping. The paper also proposes a new vertex mapping approach which minimizes complete exhaustion of substrate nodes while still providing good overall resource utilization. Experimental results are presented to show under what circumstances the proposed vertex mapping approach can provide superior VN embedding properties compared to the other approaches.
Author ' s personal copy Goal agreement and relationship quality among college students and their parents

Two hundred eight parent–college student dyads (total N = 416) participated in the current study, which examined the link between goal agreement and perceived conflict within their relationships. Undergraduate participants (91 male, 117 female) completed a demographic form, a 65 items goal measure, and a measure of parental conflict. Parents (98 fathers, 110 mothers) were asked to rate the importance of the same 65 goals for their emerging adult children. College students tended to place more importance on independence, affect control, health, social relationships, and financial concern goals than their parents did, whereas parents placed more importance on moral and religious goals than their emerging adult children did. However, relative goal agreement between parents and college students was found to be moderately high. Those parent–college student dyads who experienced less conflict tended to have higher goal agreement, whereas those dyads with a higher level of conflict had lower goal agreement. These findings provide further evidence for the link between interpersonal relationships and the personality construct of goals. 2009 Elsevier Ltd. All rights reserved.
Aspirin enhances protective effect of fish oil against thrombosis and injury‐induced vascular remodelling

Although aspirin (acetylsalicylic acid) is commonly used to prevent ischaemic events in patients with coronary artery disease, many patients fail to respond to aspirin treatment. Dietary fish oil (FO), containing ω3 polyunsaturated fatty acids (PUFAs), has anti‐inflammatory and cardio‐protective properties, such as lowering cholesterol and modulating platelet activity. The objective of the present study was to investigate the potential additional effects of aspirin and FO on platelet activity and vascular response to injury.
Reconsidering the Soleus Muscle Flap for Coverage of Wounds of the Distal Third of the Leg

Traditionally, cross-leg flaps and microsurgical flaps have been used to reconstruct defects of the distal third of the leg. In the authors’ experience, the soleus muscle has also provided suitable tissue for coverage of these lesions in a notable number of cases. During a 2-year period, the authors treated 28 patients who required flap coverage of defects of the lower third of the leg. In this group, the soleus muscle was used successfully in 8 patients. All of these procedures resulted in healed wounds. The remaining patients underwent reconstruction with microsurgical flaps, fasciocutaneous local flaps, and a gastrocnemius muscle flap. Their experience has demonstrated that the soleus muscle is a valuable tool and should be included in the treatment algorithm for reconstructing lesions of the distal third of the lower extremity.
Analgesic use: A predictor of chronic pain in medication overuse headache: The Head-HUNT Study

1. Miller JW, Selhub J, Nadeau MR, Thomas CA, Feldman RG, Wolf PA. Effect of Ldopa on plasma homocysteine in PD patients: relationship to B-vitamin status. Neurology 2003;60:1125–1129. 2. Clarke S. Protein methylation. Curr Opin Cell Biol 1993;5:977–983. 3. Bottiglieri T, Hyland K. S-adenosyl-methionine levels in psychiatric and neurologic disorders. Acta Neurol Scand 1994;suppl 154:19–26. 4. Werner P, Di Rocco A, Prikhojan A, et al. COMT-dependent protection of dopaminergic neurons by methionine, dimethionine, and S-adenosylmethionine (SAM-e) against L-Dopa toxicity in vitro: implications for Parkinson’s disease treatment. Brain Res 2001;893:278–281. 5. Cai H, Wang X, Colagiuri S, Wilcken DE. Methionine synthase D919G mutation in type 2 diabetes and its relation to vascular events. Diabetes Care 1998;10:1774–1775. 6. Widner B, Leblhuber F, Frick B, Laich A, Artner-Dworzak E, Fuchs D. Moderate hyperhomocysteinaemia and immune activation in Parkinson’s disease. J Neural Transm 2002;109:1445–1452. 7. Widner B, Leblhuber F, Fuchs D. Increased neopterin production and tryptophan degradation in advanced Parkinson’s disease. J Neural Transm 2002;109:181–189. 8. Schroecksnadel K, Frick B, Winkler C, Leblhuber F, Wirleitner B, Fuchs D. Hyperhomocysteinemia and immune activation. Clin Exp Immunol (in press). 9. Fuchs D, Jaeger M, Widner B, Wirleitner B, Artner-Dworzak E, Leblhuber F. Is hyperhomocysteinemia due to oxidative depletion of folate rather than insufficient dietary intake? Clin Chem Lab Med 2001;39:691–694. 10. Chalmers JP, Baldessarini RJ, Wurtman RJ. Effects of L-dopa on norepinephrine metabolism in the brain. Proc Natl Acad Sci 1971;68:662– 666. 11. Ordonez LA, Wurtman RJ. Methylation of exogenous 3,4-dihydroxyphenylalanine (L-Dopa)—effects on methyl group metabolism. Biochem Pharmacol 1973;22:134–137. 12. Miller JW, Shukitt-Hale B, Villalobos-Molina R, Nadeau MR, Selhub J, Joseph JA. Effect of L-dopa and the catechol-O-methyltransferase inhibitor Ro 41-0960 on sulfur amino acid metabolites in rats. Clin Neuropharmacol 1997;20:55–66. 13. Daly D, Miller JW, Nadeau MR, Selhub J. The effect of L-dopa administration and folate deficiency on plasma homocysteine concentrations in rats. J Nutr Biochem 1997;8:634–640.
Search for fMRI BOLD signals in networks of spiking neurons

In a recent experiment, functional magnetic resonance imaging blood oxygen level‐dependent (fMRI BOLD) signals were compared in different cortical areas (primary‐visual and associative), when subjects were required covertly to name images in two protocols: sequences of images, with and without intervening delays. The amplitude of the BOLD signal in protocols with delay was found to be closer to that without delays in associative areas than in primary areas. The present study provides an exploratory proposal for the identification of the neural activity substrate of the BOLD signal in quasi‐realistic networks of spiking neurons, in networks sustaining selective delay activity (associative) and in networks responsive to stimuli, but whose unique stationary state is one of spontaneous activity (primary). A variety of observables are ‘recorded’ in the network simulations, applying the experimental stimulation protocol. The ratios of the candidate BOLD signals, in the two protocols, are compared in networks with and without delay activity. There are several options for recovering the experimental result in the model networks. One common conclusion is that the distinguishing factor is the presence of delay activity. The effect of NMDAr is marginal. The ultimate quantitative agreement with the experiment results depends on a distinction of the baseline signal level from its value in delay‐period spontaneous activity. This may be attributable to the subjects' attention. Modifying the baseline results in a quantitative agreement for the ratios, and provided a definite choice of the candidate signals. The proposed framework produces predictions for the BOLD signal in fMRI experiments, upon modification of the protocol presentation rate and the form of the response function.
Patterns of recurrence following curative resection alone for adenocarcinoma of the rectum and sigmoid colon

Two‐hundred‐four patients with previously untreated adenocarcinoma of rectum, rectosigmoid, and sigmoid colon were retrospectively evaluated to determine patterns of recurrence following curative resection. Seventy‐eight (38%) subsequently developed recurrent disease. Of these, 40% (31/78) presented with local recurrence alone, 28% (22/78) with regional recurrence, 15% (12/78) with concomitant local recurrence and distant metastasis, and 17% (13/78) with distant metastasis alone. The degree of tumor anaplasia and depth of tumor penetration into the bowel wall influenced the rate of local recurrence. Through five years local recurrence without clinical evidence of distant metastasis was the most common cause of death. Need for adjuvant radiation therapy is discussed.
Impairment of Sprint Mechanical Properties in an Actual Soccer Match: A Pilot Study.

PURPOSE To assess soccer-specific impairment of mechanical properties in accelerated sprinting and its relation with activity profiles during an actual match. METHODS Thirteen male field players completed 4 sprint measurements, wherein running speed was obtained using a laser distance-measurement system, before and after the 2 halves of 2 soccer matches. Macroscopic mechanical properties (theoretical maximal horizontal force [F0], maximal horizontal sprinting power [Pmax], and theoretical maximal sprinting velocity [V0]) during the 35-m sprint acceleration were calculated from speed-time data. Players' activity profiles during the matches were collected using global positioning system units. RESULTS After the match, although F0 and Pmax did not significantly change, V0 was reduced (P = .038), and the magnitude of this reduction correlated with distance (positive) and number (negative) of high-speed running, number of running (negative), and other low-intensity activity distance (negative) during the match. Moreover, Pmax decreased immediately before the second half (P = .014). CONCLUSIONS The results suggest that soccer-specific fatigue probably impairs players' maximal velocity capabilities more than their maximal horizontal force-production abilities at initial acceleration. Furthermore, long-distance running, especially at high speed, during the match may induce relatively large impairment of maximal velocity capabilities. In addition, the capability of producing maximal horizontal power during sprinting is presumably impaired during halftime of a soccer match with passive recovery. These findings could be useful for players and coaches aiming to train effectively to maintain sprinting performance throughout a soccer match when planning a training program.
Fezf1 is required for penetration of the basal lamina by olfactory axons to promote olfactory development

In the development of the olfactory system, olfactory receptor neurons (ORNs) project their axons from the olfactory epithelium (OE) to the olfactory bulb (OB). The surface of the OB is covered by the central nervous system (CNS) basal lamina. To establish this connection, pioneer axons of the ORNs penetrate the CNS basal lamina at embryonic day 12.5 in mice. The importance of this penetration is highlighted by the Kallmann syndrome. However, little has been known about the molecular mechanism underlying this penetration process. Fezf1 (also called as Fez, Zfp312‐like, and 3110069A13Rik) is a C2H2‐type zinc‐finger gene expressed in the OE and hypothalamic region in mice. In Fezf1‐deficient mice, ORN axons (olfactory axons) do not reach the OB. Here we demonstrate that Fezf1‐deficient olfactory axons do not penetrate the CNS basal lamina in vivo, and the penetration activity of the axons in Matrigel is impaired in vitro. Coculture experiments using the OE and OB reveal that axonal projection of ORNs is rescued in Fezf1‐deficient mice in which the meninges including the CNS basal lamina are removed from the mutant OB. These data indicate that Fezf1 is required for the penetration of olfactory axons through the CNS basal lamina before they innervate the OB. J. Comp. Neurol. 515:565–584, 2009. © 2009 Wiley‐Liss, Inc.
The Repeat Appointment Factor - Exploring Decision Patterns of Elite Investment Arbitrators

This Article analyzes the judicial behavior of repeatedly appointed arbitrators. Focusing on repeat investment arbitrators, the research empirically controverts the conventional wisdom that arbitrators tend to render compromise awards and the perception that investment arbitrators are biased in favor of investors. The research explores the decisions-patterns of repeat investment arbitrators on three levels, the tribunal as a whole, the appointment status of arbitrators on the tribunal, and the individual level. By distinguishing repeat arbitrators as a group and differentiating between the roles that they play on a tribunal, this research seeks to present a more nuanced understanding of arbitral decision-making. The research shows that repeat arbitrators display no biases and no tendencies to ‘split the difference’. It further shows that repeat presiding arbitrators are less averse to extreme outcomes than party-appointed arbitrators. Finally, the research shows that the arbitrators’ decision records, examined individually, do not always display a balanced decision pattern over time. The research concludes that the arbitrators’ incentive to maintain their reputations as experienced and unbiased experts may lead them to grant an award, uninfluenced by the purported need to satisfy the parties or any of them.
Knowledge Graph Embeddings in Geometric Algebras

Knowledge graph (KG) embedding aims at embedding entities and relations in a KG into a low dimensional latent representation space. Existing KG embedding approaches model entities and relations in a KG by utilizing real-valued , complex-valued, or hypercomplex-valued (Quaternion or Octonion) representations, all of which are subsumed into a geometric algebra. In this work, we introduce a novel geometric algebra-based KG embedding framework, GeomE, which utilizes multivector representations and the geometric product to model entities and relations. Our framework subsumes several state-of-the-art KG embedding approaches and is advantageous with its ability of modeling various key relation patterns, including (anti-)symmetry, inversion and composition, rich expressiveness with higher degree of freedom as well as good generalization capacity. Experimental results on multiple benchmark knowledge graphs show that the proposed approach outperforms existing state-of-the-art models for link prediction.
Origins of Biliary Copper

We tested the hypothesis that the copper present in bile‐the major route of elimination of the metal from the body‐is derived exclusively from hepatocytes by administering radiocopper (84Cu or 67Cu)‐labeled ionic Cu, desialylated (AsCPN) or intact human ceruloplasmin (CPN), intravenously, to rats with cannulated bile ducts. The rates of appearance and the total amounts of radiolabeled isotope recovered in bile were measured. The three vehicles chosen for the delivery of radiocopper interact differently with hepatocytes: ionic Cu is taken up by a passive process (Schmitt, R. C. et al., Am. J. Physiol. 1983; 244:G183‐G191); AsCPN is promptly cleared from the circulation by specific receptor‐mediated endocytosis, and CPN largely remains in the circulation for the duration of the experiment. Similar amounts of radiocopper were recovered following injections of ionic Cu (3.1%) or CPN (2%), but substantially larger amounts (8.1%) were excreted after administration of AsCPN. Using an antibody to CPN which reacts also with AsCPN, we found about 70% of the bile radioactivity to be immunoprecipitable following injections of either glycoprotein, indicating that a fraction of these copper proteins had entered the bile essentially unmodified. Our observations indicate that in addition to the lysosomal compartment which catabolizes a portion of the AsCPN in hepatocytes, there appears to be a direct route for AsCPN from hepatocellular sinusoids to the bile canaliculi. Since CPN does not interact significantly with hepatocytes, its presence in bile suggests transcytosis via the biliary epithelium.
Diverse nature of posterolateral tibial plateau fractures: a new thinking concept.

To the Editor: We read with great interest the technical trick by Frosch et al, “A new posterolateral approach without fibula osteotomy for the treatment of tibial plateau fractures” describing a new posterolateral approach without fibula osteotomy for the treatment of tibial plateau fractures. This study clearly outlines the importance of posterolateral fractures that are underappreciated by most surgeons. In their article, the authors mention that approximately 7% of tibial plateau fractures are in this region, but they did not state the particular morphological type of fracture. Therefore it may be a misconception. We would like to point out previous research regarding depression fractures of the posterolateral corner. Different entities should not be grouped together as they are different in treatment strategies and prognosis. In our observation, the high incidence (7%) is a misconception and the fractures must be verified and an accurate diagnosis obtained. Preoperative computed tomographic scanning is essential to delineate this exact fracture morphology. We have recognized the 3 different forms of posterolateral injury pattern as depicted in Figure 1. In our experience, posterolateral fractures can occur individually or in combination with different forms of posteromedial fractures in posterior shearing injury or with anterolateral fractures. Several investigators have discussed surgical approaches and fixation maneuvers to fix coronal plane fractures. Our belief is that the first step should be the understanding of the fracture pattern. Posterolateral pure split, depressions, and fracture depressions are different forms of injury reflecting the increasing magnitude of energy. The proposed mechanism is combined valgus, axial force, and knee flexion. The exact incidence of various injuries to the posterolateral quadrant, fracture rationale, and prognosis should be reported to minimize the conflict and pitfalls in the literature. We believe that it is critical to place the diversity of posterolateral plateau fractures in different subgroups for both optimal results and research prospect.
Effects of higher-order aberration correction on stereopsis at different viewing durations

Abstract. To better understand how the eye’s optics affects stereopsis, we measured stereoacuity before and after higher-order aberration (HOA) correction with a binocular adaptive optics visual simulator. The HOAs were corrected either binocularly or monocularly in the better eye (the eye with better contrast sensitivity). A two-line stereo pattern served as the visual stimulus. Stereo thresholds at different viewing durations were obtained with the psychophysical method of constant stimuli. Binocular HOA correction led to significant improvement in stereoacuity. However, better eye HOA correction could bring either a bad degradation or a slight improvement in stereoacuity. As viewing duration increased, the stereo benefit approached the level of 1.0 for both binocular and better eye correction, suggesting that long viewing durations might weaken the effects of the eye’s optical quality on stereopsis.
Structure of Alfvén waves at the skin‐depth scale

This analytical study demonstrates that shear Alfven waves having transverse scale on the order of the electron skin depth exhibit a collisionless divergence determined by propagation cones that emanate from the edges of the exciting structures. Axial current channels are found to spread radially due to the skin effect up to the cone trajectories and at distances of a few wavelengths from the exciter develop radial diffraction patterns. For values of the collision frequency slightly larger than the wave frequency resistive diffusion allows the axial currents to expand beyond the cone trajectories.