Miracle-dz/UniFAR-FTUs huggingface dataset:
MECHANOSENSORY PERCEPTION: ARE THERE CONTRIBUTIONS FROM BONE‐ASSOCIATED RECEPTORS?

1. The identity of the receptors and afferent nerve fibres that mediate the sense of touch varies somewhat with body location. Those that have been most intensively characterized are associated with the distal glabrous skin of the limbs and, in primates, mediate the sense of touch in the fingertips and palms. In this glabrous skin region, there appear to be three or four principal classes of tactile sensory nerves that fall into two broad groups. One group, the so‐called slowly adapting (SA) receptors and afferent fibres, is responsive to static mechanical displacement of skin tissues and is made up of two classes, the type I (SAI) fibres that innervate Merkel receptors and the type II (SAII) fibres that innervate Ruffini endings. The second broad group displays a pure dynamic sensitivity to tactile stimuli and also falls into two principal classes, the rapidly adapting (RA) tactile fibres that are associated with Meissner corpuscle receptors and the Pacinian corpuscle (PC)‐associated class of tactile afferent fibres.
Adverse reaction after hyaluronan injection for minimally invasive papilla volume augmentation. A report on two cases.

OBJECTIVES To report two cases of adverse reaction after mucosal hyaluronan (HY) injection around implant-supported crowns, with the aim to augment the missing interdental papilla. MATERIAL AND METHODS Two patients with single, non-neighbouring, implants in the anterior maxilla, who were treated within the frames of a randomized controlled clinical trial testing the effectiveness of HY gel injection to reconstruct missing papilla volume at single implants, presented an adverse reaction. Injection of HY was performed bilaterally using a 3-step technique: (i) creation of a reservoir in the mucosa directly above the mucogingival junction, (ii) injection into the attached gingiva/mucosa below the missing papilla, and (iii) injection 2-3 mm apically to the papilla tip. The whole-injection session was repeated once after approximately 4 weeks. RESULTS Both patients presented with swelling and extreme tenderness with a burning sensation on the lip next to the injection area, after the second injection session. In one of the cases, a net-like skin discoloration (livedo reticularis) was also noted. The symptoms lasted for up to 7 days, and in both cases, symptoms resolved without any signs of skin or mucosal necrosis or any permanent damage. CONCLUSION Most likely, water attraction over time by the highly hygroscopic HY, exerted progressively an external vascular compression and at least partial occlusion of neighbouring blood vessels. An infection or an allergic reaction seems unlikely, since all symptoms gradually disappeared within a week irrespective use of antimicrobials, while an allergic reaction most likely would not have been restricted to one side.
Obstetric complications in autism: consequences or causes of the condition?

OBJECTIVE To determine whether and why obstetric complications are associated with autism. METHOD Obstetric histories, obtained at maternal interview and coded as an optimality score (OS), were compared in two groups: 78 families containing an autistic proband (ICD-10 criteria) and 27 families containing a down syndrome (DS) proband. The OS was examined in relation to offspring diagnosis, proband characteristics, and familial loading for autism and its phenotypic variants. RESULTS Autistic and DS probands had a significantly elevated OS compared with unaffected siblings, regardless of birth order position. The elevation was mainly due to an increase in mild as opposed to severe obstetric adversities. In autistic probands, the OS was best predicted by familial loading for autism and its phenotypic variants, but in the absence of this measure by the number of autistic symptoms. Among siblings of autistic probands affected with autism or its variants, the OS was best predicted by the probands' OS, and in its absence, by the measure of familial loading. In DS probands and siblings the OS was associated with increased maternal age, although this did not account for the OS elevation in DS probands. CONCLUSIONS Rather than playing any principal etiological role, the obstetric adversities associated with autism either represent an epiphenomenon of the condition or derive from some shared risk factor(s).
Moral Support: How Moral Values Shape Foreign Policy Attitudes

Although classical international relations theorists largely agreed that public opinion about foreign policy is shaped by moral sentiments, public opinion scholars have yet to explore the content of these moral values, and American IR theorists have tended to exclusively associate morality with liberal idealism. Integrating the study of American foreign policy attitudes with Moral Foundations Theory from social psychology, we present original survey data showing that the five established moral values in psychology—harm/care, fairness/reciprocity, authority/respect, ingroup/loyalty, and purity/sanctity—are strongly and systematically associated with foreign policy attitudes. The “individualizing” foundations of harm/care and fairness/reciprocity are particularly important drivers of cooperative internationalism and the “binding” foundations of authority/respect, ingroup/loyalty, and purity/sanctity of militant internationalism. Hawks and hardliners have morals too, just a different set of moral values than the Enlightenment ones emphasized by liberal idealists.
Relationship between Bone Health Biomarkers and Cardiovascular Risk in a General Adult Population

Purpose/Introduction: Osteoporosis (OP) and cardiovascular (CV) disease emerge as closely related conditions, showing common risk factors and/or pathophysiological mechanisms. The aim of this study was to evaluate the association between bone health markers (BHM) and individual CV risk factors and overall CV risk (FRAMINGHAM-FRS, and PROCAM scores) in a general adult population. Methods: In 103 subjects (21 males; age: 56 ± 12 years), vitamin D (25(OH)D), osteocalcin (OC), bone alkaline phospatase (BALP), procollagen I aminoterminal propeptide (P1NP), CTx-telopeptide, as well clinical history and life style were evaluated. Results: Aging (p < 0.001) and glycemia (p < 0.05) emerged as independent 25(OH)D predictors. Aging (p < 0.001), male sex (p < 0.05), and obesity (p < 0.05) represented independent OC determinants. Aging (p < 0.05) was the only independent BALP determinant. After multivariate adjustment, low 25(OH)D (<20 ng/mL) (Odds ratio OR (95% confidence intervals CI)) (5 (1.4–18) p < 0.05) and elevated OC (>75th percentile-16.6 ng/mL) (6.7 (1.9–23.8) p < 0.01) were found to be significant FRS predictors, while subjects with elevated OC and/or BALP (>75th percentile-9.8 μg/L) showed a higher CV risk as estimated by PROCAM (3.6 (1.2–10.7) p < 0.05). CTx and P1NP did not significantly correlate with CV risk factors or scores. Conclusion: As we go further into bone and CV physiology, it is evident that a close relationship exists between these diseases. Further studies are needed to investigate mechanisms by which bone turnover markers are related to metabolic risk and could modulate CV risk. This knowledge may help to develop possible multiple-purpose strategies for both CV disease and OP prevention and treatment.
Cloud radar Doppler spectra in drizzling stratiform clouds: 1. Forward modeling and remote sensing applications

[1] Several aspects of spectral broadening and drizzle growth in shallow liquid clouds remain not well understood. Detailed, cloud-scale observations of microphysics and dynamics are essential to guide and evaluate corresponding modeling efforts. Profiling, millimeter-wavelength (cloud) radars can provide such observations. In particular, the first three moments of the recorded cloud radar Doppler spectra, the radar reflectivity, mean Doppler velocity, and spectrum width, are often used to retrieve cloud microphysical and dynamical properties. Such retrievals are subject to errors introduced by the assumptions made in the inversion process. Here, we introduce two additional morphological parameters of the radar Doppler spectrum, the skewness and kurtosis, in an effort to reduce the retrieval uncertainties. A forward model that emulates observed radar Doppler spectra is constructed and used to investigate these relationships. General, analytical relationships that relate the five radar observables to cloud and drizzle microphysical parameters and cloud turbulence are presented. The relationships are valid for cloud-only, cloud mixed with drizzle, and drizzle-only particles in the radar sampling volume and provide a seamless link between observations and cloud microphysics and dynamics. The sensitivity of the five observed parameters to the radar operational parameters such as signal-to-noise ratio and Doppler spectra velocity resolution are presented. The predicted values of the five observed radar parameters agree well with the output of the forward model. The novel use of the skewness of the radar Doppler spectrum as an early qualitative predictor of drizzle onset in clouds is introduced. It is found that skewness is a parameter very sensitive to early drizzle generation. In addition, the significance of the five parameters of the cloud radar Doppler spectrum for constraining drizzle microphysical retrievals is discussed.
Shill Bidding and Information in Sequential Auctions: A Laboratory Study

Second-price auctions with public information, such as those on eBay, provide an opportunity for sellers to use the information from finished and ongoing auctions when acting strategically in future auctions. Sellers have frequently been observed to bidding on their own item with the intent to artificially increase its price. This is known as shill bidding. Using lab experiments with two sequential auctions, we study the effect of shill bidding when the seller can choose to shill bid in the second auction. We also study the impact of different information revelation policies regarding the provision of the first auction bidding history to the seller. The experimental data confirm that shill bidding in the second auction affects outcomes in both auctions. Our findings are consistent with the predictions that the threat of shill bidding in the second auction does increase the bidders' final bid in the first auction. However, providing the seller with the bidding history from the first auction does not affect any important outcome variables.
The Effects of Quality of Work Life on Burnout Syndrome: A Study on Hospitality Industry

The purpose of the study is to determine whether the quality of work life of the employees of the hospitality industry is affected by Burnout Syndrome. For this reason, 410 employees who work in 65 independent enterprises awarded 4 and 5 stars, which are members of the Hotel Association of Turkey (TUROB), also a non-governmental organization, operating in the districts of Fatih, Beyoglu, Şisli, Besiktas and Ataturk Airport area of the province of Istanbul, were reached by means of questionnaires and the data were then collected. As a result of the analysis on the obtained data, it was determined that there are various levels of relationship and effects between the work life quality of the hospitality industry employees and their burnout syndromes. It is also achieved that the work life qualities of the employees are moderate, and they experience the burnout in the middle level.
Comparison of isotopic and immunohistochemical methods of studying epithelial cell proliferation in hamster tongue

Our purpose was to validate different approaches to the study of cell proliferation in stratified squamous epithelia, using oral mucosa as a model. Dorsal and ventral tongue from the hamster were examined following in vivo labelling with tritiated thymidine and bromodeoxyuridine (BrdUrd), and in vitro labelling with BrdUrd. These were compared with direct immunolabelling of fixed tissue sections with monoclonal antibody PC10. For the former methods S phase cells were quantified following autoradiography or immunohistochemistry. We conclude that the proliferative status of simple, flat, lining mucosae such as ventral tongue can be derived by all three prelabelling methods and, on average, 18–19 cells per surface millimetre length were in DNA synthesis. On the other hand dorsal tongue epithelium, which is thicker, has an undulating morphology and a complex cell renewal pattern, gives different results with the three labelling methods. In both sites the proliferating cell nuclear antigen (PCNA) index was fourfold that obtained by nucleotide labelling. This is consistent with PCNA marking proliferative cells in other phases of the cell cycle in addition to the S phase. Thus, there are potential differences between the information on proliferative status derived by PCNA immunohistochemistry and other established cell cycle markers, which need to be taken into account in the interpretation of epithelial cell kinetic data in health and disease.
Cricoid Cartilage Pressure Decreases Lower Esophageal Sphincter Tone

Background Cricoid cartilage pressure induced to prevent pulmonary aspiration from regurgitation of gastric contents has been recommended, and its efficacy requires a force greater than 40 Newtons. For regurgitation to occur, both an increase in gastric pressure and relaxation of the lower esophageal sphincter (LES) are necessary. However, the effect of cricoid cartilage pressure on the LES is unknown. This study evaluated the effects of cricoid cartilage pressure on LES in human volunteers. Methods Lower esophageal sphincter and esophageal barrier pressures (which equals LES pressure‐gastric pressure) were measured using a manometric method in eight unanesthetized volunteers (4 men, 4 women) classified as American Society of Anesthesiologists physical status 1. The force applied to the cricoid cartilage was measured continuously, and LES pressure was recorded at a cricoid force of 20 and 40 Newtons. Results Cricoid pressure decreased LES pressure from 24 +/‐ 3 mmHg to 15 +/‐ 4 mmHg at a force of 20 Newtons (P < 0.05) and to 12 +/‐ 4 mmHg with a force of 40 Newtons (P < 0.01). Conclusions These findings may explain the occurrence of pulmonary aspiration before tracheal intubation despite application of cricoid cartilage pressure.
Androgen receptor targeted therapies in castration‐resistant prostate cancer: Bench to clinic

The androgen receptor is a transcription factor and validated therapeutic target for prostate cancer. Androgen deprivation therapy remains the gold standard treatment, but it is not curative, and eventually the disease will return as lethal castration‐resistant prostate cancer. There have been improvements in the therapeutic landscape with new agents approved, such as abiraterone acetate, enzalutamide, sipuleucel‐T, cabazitaxel and Ra‐223, in the past 5 years. New insight into the mechanisms of resistance to treatments in advanced disease is being and has been elucidated. All current androgen receptor‐targeting therapies inhibit the growth of prostate cancer by blocking the ligand‐binding domain, where androgen binds to activate the receptor. Persuasive evidence supports the concept that constitutively active androgen receptor splice variants lacking the ligand‐binding domain are one of the resistant mechanisms underlying advanced disease. Transcriptional activity of the androgen receptor requires a functional AF‐1 region in its N‐terminal domain. Preclinical evidence proved that this domain is a druggable target to forecast a potential paradigm shift in the management of advanced prostate cancer. This review presents an overview of androgen receptor‐related mechanisms of resistance as well as novel therapeutic agents to overcome resistance that is linked to the expression of androgen receptor splice variants in castration‐resistant prostate cancer.
The actomyosin engine

Two recent advances have extended our knowledge of the actomyosin interaction considerably. The first of these is the determination of the crystal structures of the actin monomer and of the myosin head. The structures of these proteins were fit into the quaternary protein complexes of the actin filament, and of the actin filament decorated by the myosin head, using data from fiber diffraction or electron microscopy as constraints. The atomic models of these protein complexes have led to new hypotheses concerning the large conformational changes that must occur in these proteins in order to generate force. The second advance has been the measurement of the forces and displacements of single motor proteins, in particular, of a single myosin molecule interacting with a single actin filament. These data lead to more unambiguous interpretations than did previous mechanical data, which were obtained using ensembles of motors that worked asynchronously on their filaments. This approach brings to the motor field the equivalent of what patch clamp techniques brought to the study of membrane channels: the ability to look at the function of a single molecule. —Cooke, R. The actomyosin engine. FASEB J. 9, 636‐642 (1993)
Moral courage in the workplace: moving to and from the desire and decision to act

Why is moral courage in the workplace viewed as the unusual, rather than the norm? If we want to cultivate organizational environments that exhibit moral strength, we must consider how courage can be exercised in daily organizational life, as an action that can be achieved by everyone. To explore this notion, we see a need to develop additional understanding of how people determine whether or not they will act in a morally courageous way when faced with an ethical challenge. While existing theory sheds light on various aspects of ethical decision making, missing from the literature is an examination of how emotions, automatic responses to situational conditions, along with conscious and deliberative thought, work together to help guide this process. Yet to be fully explored are the internal factors and the social influences that accompany them, specifically those that contribute to forming the desire and decision to act with moral courage. We argue that scholarship designed to explain how this process unfolds will reshape our understanding of moral courage as an action open to self-control, and thus can occur more frequently than the rare event it is often presumed to be. Our depiction of the organizational member’s response to an ethical challenge helps take moral courage out of the extraordinary and into the realm of what can be achieved by most people, at least some of the time. Leading scholars in the area of ethical decision making have put forth an invitation to integrate constructs, topics and issues that span academic fields, taking a cross-disciplinary approach (Payne & Giacalone 1990, Treviño 1992). We accept this call and propose a process orientation to the study of moral conduct, one that is grounded in the behavioural sciences but mindful of philosophical contributions. Considering the recent focus on positive organizational scholarship (Cameron et al. 2003), we also show how moral courage can be better understood, encouraged and taught, by learning what contributes to organizational moral flourishing. If organizational members are expected to conduct themselves with exemplary standards of ethical behaviour, it is the responsibility of scholars and managers to provide clarity on how to do so effectively. To address this concern we ask, What induces people to act in morally courageous ways as they face an ethical challenge in the workplace? Our starting assumption is that moral courage can be realized and achieved by most organizational members, under certain personal and situational conditions. To build Respectively: Assistant Professor, Organizational Behavior and Ethics, Graduate School of Business & Public Policy, Naval Postgraduate School, Monterey, CA, USA; and Professor of Marketing, Stephen M. Ross School of Business & Professor of Social and Administrative Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, MI, USA.
Misoprostol versus curettage in women with early pregnancy failure after initial expectant management: a randomized trial.

BACKGROUND Little is known about the effectiveness of misoprostol treatment in women with early pregnancy failure who have been managed expectantly. We therefore performed a randomized trial on this subject. METHODS Women with early pregnancy failure, who had been managed expectantly for at least 1 week, were assigned randomly (using a computer-generated list) to receive either vaginal misoprostol 800 microg or curettage. If, after 24 h, there had not been complete evacuation, a further 800 microg of misoprostol was administered. In the absence of complete evacuation after > days, curettage was performed. The primary end-point was the complete evacuation of the products of conception, with secondary end-points being the occurrence of side effects, pain intensity, need for analgesics, and intensity and duration of bleeding. RESULTS In the misoprostol group, 47% (37/79) required curettage due to incomplete evacuation. After 1 week, evacuation was complete in 85% (67 out of 79) of the misoprostol group and 93% (70 out of 75) of the curettage group. Severity of pain, bleeding and emergency evacuation was higher in the misoprostol group. The complication rate was 0% for misoprostol and 4% for curettage. CONCLUSIONS Curettage is superior to misoprostol in the evacuation of early pregnancy failure after failed expectant management. However, misoprostol could be clinically useful since it reduces the need for curettage by half and has a lower complication rate, at the expense of increased pain, vaginal bleeding and emergency evacuation.
Strategic Philanthropists: Who Are They and Do They Matter?

Anecdotal evidence suggests that charitable givers – particularly those with the financial means and inclination to make substantial donations – are increasingly strategic in their philanthropic behavior. This study is the first econometric investigation of individual strategic giving, that is giving which is planned, concentrated, and where the donor is also involved as a volunteer. Approximately 3% of the total giver population gives strategically in Canada. We find that the propensity to give strategically is strongly and positively correlated with the level of education and youth experiences, and that strategic givers are substantially more generous than non-strategic givers, particularly after controlling for endogeneity. Strategic giving has a large positive impact on the amount donated to secular organisations, but has no effect whatsoever on the level of religious giving, supporting the view that religious gifts should be modelled differently from non-religious gifts.
Does Financial Reporting Quality Vary Across Firm Life Cycle?

We perform a comprehensive analysis on the relation between a firm’s life cycle and its financial reporting quality. Using abnormal accruals, abnormal revenues, restatements, and others, we provide evidence that there is considerable variation in financial reporting quality across the life cycle. We observe an inverted U-shaped pattern of financial reporting quality, i.e., absolute values of abnormal accruals and abnormal revenues are higher (lower) during the introduction, growth, shakeout, and decline (mature) stages. This pattern is driven by poor matching of current expenses with current revenues during the introduction and decline stages. Further, the likelihood of a restatement is higher in the introduction, shakeout, and decline stages, whereas the likelihood of an enforcement action is higher for growth firms relative to mature firms. Finally, the likelihood of a weakness in internal controls and the level of audit fees are higher for firms in the introduction and growth stages.