Miracle-dz/UniFAR-FTUs huggingface dataset:
CO-Dark Star Formation and Black Hole Activity in 3C 368 at z = 1.131: Coeval Growth of Stellar and Supermassive Black Hole Masses

We present the detection of four far-infrared fine-structure oxygen lines, as well as strong upper limits for the CO(2–1) and [N ii] 205 μm lines, in 3C 368, a well-studied radio-loud galaxy at z = 1.131. These new oxygen lines, taken in conjunction with previously observed neon and carbon fine-structure lines, suggest a powerful active galactic nucleus (AGN), accompanied by vigorous and extended star formation. A starburst dominated by O8 stars, with an age of ∼6.5 Myr, provides a good fit to the fine-structure line data. This estimated age of the starburst makes it nearly concurrent with the latest episode of AGN activity, suggesting a link between the growth of the supermassive black hole and stellar population in this source. We do not detect the CO(2–1) line, down to a level twelve times lower than the expected value for star-forming galaxies. This lack of CO line emission is consistent with recent star formation activity if the star-forming molecular gas has low metallicity, is highly fractionated (such that CO is photodissociated throughout much of the clouds), or is chemically very young (such that CO has not yet had time to form). It is also possible, although we argue it is unlikely, that the ensemble of fine-structure lines is emitted from the region heated by the AGN.
Chemical Composition and Product Quality Control of Turmeric (Curcuma longa L.)

Chemical constituents of various tissues of turmeric (Curcuma longa L.) have been extensively investigated. To date, at least 235 compounds, primarily phenolic compounds and terpenoids have been identified from the species, in- cluding 22 diarylheptanoids and diarylpentanoids, eight phenylpropene and other phenolic compounds, 68 monoterpenes, 109 sesquiterpenes, five diterpenes, three triterpenoids, four sterols, two alkaloids, and 14 other compounds. Curcumi- noids (diarylheptanoids) and essential oils are major bioactive ingredients showing various bioactivities in in vitro and in vivo bioassays. Curcuminoids in turmeric are primarily accumulated in rhizomes. The essential oils from leaves and flowers are usually dominated by monoterpenes while those from roots and rhizomes primarily contained sesquiterpenes. The contents of curcuminoids in turmeric rhizomes vary often with varieties, locations, sources, and cultivation condi- tions, while there are significant variations in composition of essential oils of turmeric rhizomes with varieties and geo- graphical locations. Further, both curcuminoids and essential oils vary in contents with different extraction methods and are unstable with extraction and storage processes. As a result, the quality of commercial turmeric products can be mark- edly varied. While curcumin (1), demethoxycurcumin (2), and bisdemethoxycurcumin (5) have been used as marker com- pounds for the quality control of rhizomes, powders, and extract ("curcumin") products, Ar-turmerone (99), � -turmerone (100), and � -turmerone (101) may be used to control the product quality of turmeric oil and oleoresin products. Authentication of turmeric products can be achieved by chromatographic and NMR techniques, DNA markers, with morphological and anatomic data as well as GAP and other information available.
PERINATAL CONDITIONS OF UNWANTED CHILDREN

1. In their study of children who were born after their mothers had been denied a legal abortion Forssman & Thuwe (1966) showed that the children’s mental health, social adjustment and educational level were more unfavourable than in appropriate controls. The authors interpretation of their findings is that the mothers transmit their mental vulnerability to the children either through genes or via lack of stability and security in the home environment. The latter hypothesis was supported by a comparison of those unwanted children and their controls who were living with both their real parents until they were 15; these reduced groups did not differ significantly with the criteria used (although there still was a similar tendency). We wanted to extend this analysis by examining whether, in addition to a genetic and social handicap, there was also a physical handicap, i.e. whether the new-borii children displayed any deviations in the regularly registered features weight, length, head circumference, intrauterine growth rate, prematurity, perinatal mortality and malformations, all of which might reflect an adverse prenatal influence on the foetus.
Definition of human immunodeficiency virus type 1 gp120 and gp41 cytotoxic T-lymphocyte epitopes and their restricting major histocompatibility complex class I alleles in simian-human immunodeficiency virus-infected rhesus monkeys

With the development of chimeric simian-human immunodeficiency virus (SHIV)-infected macaques as a model for assessing novel human immunodeficiency virus type I (HIV-1) envelope glycoprotein (Env)-based vaccine strategies for preventing HIV-1 infection in man, it will be important to determine HIV-1 Env-specific cytotoxic T-lymphocyte (CTL) responses in vaccinated and virus-infected monkeys. To facilitate performing such CTL studies, we have defined two HIV-1 Env CTL epitopes in SHIV-infected rhesus monkeys and characterized the major histocompatibility complex (MHC) class I alleles that bind these Env peptide fragments and present them to CTL. A 9-amino-acid (aa) fragment of HIV-1 gp4l (p6B, aa 553 to 561) is presented to CD8+ CTLs of SHIV-infected animals by the rhesus monkey HLA-B homolog molecule Mamu-B*12. An 8-aa HIV-1 gpl.20 peptide (p9CD, aa 117 to 124) represents a CTL epitope in rhesus monkeys restricted by the HLA-A homolog MHC allele Mamu-A*08. This gp120 CTL epitope is fully conserved in all simian immunodeficiency virus, HIV-1, and HIV-2 isolates that have been sequenced to date and exhibits functional cross-reactivity. Screening of 14 unselected rhesus monkeys for expression of the two novel MHC class I alleles revealed the presence of each of the alleles in more than 40% of the animals. The characterization of the two HIV-1 Env CTL epitopes and their restricting MHC class I alleles will provide a basis for studying vaccine- and virus-elicited cytotoxic effector cell responses in rhesus monkeys.
Exposure to Weight-Stigmatizing Media: Effects on Exercise Intentions, Motivation, and Behavior

This study aimed to evaluate the impact of exposure to weight-stigmatizing media on exercise intentions, motivation, and behavior, as well as to examine the interaction between this exposure and past experiences with weight stigma. A community sample of 72 women were randomly assigned to view a brief weight-stigmatizing or neutral video. Participants’ choice of taking the stairs versus the elevator was observed before they completed measures of exercise intentions, motivation, and behavior; psychological well-being; and experiences with weight stigma. A follow-up survey was sent to participants 1 week later that assessed exercise behavior and intentions. Frequency of past weight stigma correlated with worse psychological well-being and more controlled (versus autonomous) exercise motivation. Significant interactions were found between past weight-stigmatizing experiences and exposure to the weight-stigmatizing video for outcomes of exercise intentions, behavior, and drive for thinness. Participants in the stigma condition with higher frequency of past experiences reported greater exercise intentions and behavior, along with higher drive for thinness. Past experiences of weight stigma interact with exposure to weight-stigmatizing media to increase exercise intentions and behavior, although this effect is accompanied by a heightened drive for thinness that may increase risk for long-term negative health consequences.
Comparison of MRI signatures in pattern I and II multiple sclerosis models

The majority of individuals with multiple sclerosis (MS) exhibit T‐cell‐ and macrophage‐dominated lesions (patterns I and II; as opposed to III and IV). These lesions, in turn, may be distinguished on the basis of whether or not there are immunoglobulin and complement depositions at the sites of active myelin destruction; such depositions are found exclusively in pattern II lesions. The main aim of this study was to determine whether pattern I and pattern II MS lesions exhibit distinct MRI signatures. We have used a recently described focal MOG‐induced EAE model of the rat brain, which recapitulates many of the hallmarks of pattern II MS; we compared this with our previous work in a delayed type hypersensitivity model of a pattern I type lesion in the rat brain. Demyelinating lesions with extensive inflammation were generated, in which the T2‐weighted signal was increased. Magnetisation transfer ratio (MTR) maps revealed loss and subsequent incomplete recovery of the structure of the corpus callosum, together with changes in tissue water diffusion and an associated increase in ventricle size. Notably, the MTR changes preceeded histological demyelination and may report on the processes leading to demyelination, rather than demyelination per se. Immunohistochemically, these MRI‐detectable signal changes correlated with both inflammatory cell infiltration and later loss of myelin. Breakdown of the blood–brain barrier and an increase in the regional cerebral blood volume were also evident in and around the lesion site at the early stage of the disease. Interestingly, however, the MRI signal changes in this pattern II type MS lesion were remarkably consistent with those previously observed in a pattern I lesion. These findings suggest that the observed signal changes reflect the convergent histopathology of the two models rather than the underlying mechanisms of the disease. Copyright © 2009 John Wiley & Sons, Ltd.
Cloud Computing Business Value and Human Determinants: An Empirical Investigation

There are high expectations that cloud computing (CC) can generate sizeable business value (BV) for firms, which includes important benefits, associated with costs reduction, agility enhancement and innovation facilitation and support. However, limited empirical research has been conducted in this direction, in order to investigate to what extent these high expectations are fulfilled, as well as the level of business value that firms realize from CC, and the magnitudes of the specific benefits that firms really obtain from it, as well as their determinants. Our paper contributes to filling this research gap. It investigates the effect of a set of human factors, which concern firm's general human capital, ICT specific human capital, as well the co-operation and relationship between the personnel of the ICT unit and the personnel of the business units, on the BV generated by CC, having as theoretical foundation the 'resource-based view' of the firm theory. For this purpose, we have used data collected through a survey from 115 firms from technologically developed sectors of the Greek economy, from which a CC BV regression model has been estimated. It has been concluded that neither firm's general human capital (quantified by the share of firm's employees having tertiary-level formal education), nor its ICT human capital (quantified by the share of ICT employees), per se impact the BV generated by CC. On the contrary, the relationship and co-operation between the ICT unit personnel and the business units' personnel have a positive effect on the BV from CC usage. Our findings indicate that it is not the mere acquisition of human resources (highly educated business and ICT employees), but their utilization for the development of capability for productive and effective co-operation and relationship among the ICT and business personnel, that can lead to higher levels of BV from CC usage.
Review of Soluble Biomarkers of Osteoarthritis: Lessons From Animal Models

Objective Osteoarthritis (OA) is one of the leading causes of disability within the adult population. Currently, its diagnosis is mainly based on clinical examination and standard radiography. To date, there is no way to detect the disease at a molecular level, before the appearance of structural changes and symptoms. So an attractive alternative for monitoring OA is the measurement of biochemical markers in blood, urine, or synovial fluid, which could reflect metabolic changes in joint tissue and therefore disease onset and progression. Animal models are relevant to investigate the early stage of OA and metabolic changes occurring in joint tissues. The goal of this narrative review is to summarize the scientific data available in the literature on soluble biomarkers in animal models of OA. Design A literature search was conducted using the PubMed/Medline and Scopus databases between February 1995 and December 2015. All original articles, systematic and narrative reviews published in French or in English were considered. Results We summarized the data of 69 studies and proposed a classification scheme for OA biomarkers in animal studies, largely inspired by the BIPEDS classification. Conclusions Studies about biomarkers and animal models indicate that some markers could be valuable to monitor OA progression and assess therapeutic response in some animal models.
Neuroprogression in schizophrenia: Pathways underpinning clinical staging and therapeutic corollaries

Objective: Whilst dopaminergic dysfunction remains a necessary component involved in the pathogenesis of schizophrenia, our current pharmacological armoury of dopamine antagonists does little to control the negative symptoms of schizophrenia. This suggests other pathological processes must be implicated. This paper aims to elaborate on such theories. Methods: Data for this review were sourced from the electronic database PUBMED, and was not limited by language or date of publication. Results: It has been suggested that multiple ‘hits’ may be required to unveil the clinical syndrome in susceptible individuals. Such hits potentially first occur in utero, leading to neuronal disruption, epigenetic changes and the establishment of an abnormal inflammatory response. The development of schizophrenia may therefore potentially be viewed as a neuroprogressive response to these early stressors, driven on by changes in tryptophan catabolite (TRYCAT) metabolism, reactive oxygen species handling and N-methyl d-aspartate (NMDA) circuitry. Given the potential for such progression over time, it is prudent to explore the new treatment strategies which may be implemented before such changes become established. Conclusions: Outside of the dopaminergic model, the potential pathogenesis of schizophrenia has yet to be fully elucidated, but common themes include neuropil shrinkage, the development of abnormal neuronal circuitry, and a chronic inflammatory state which further disrupts neuronal function. Whilst some early non-dopaminergic treatments show promise, none have yet to be fully studied in appropriately structured randomized controlled trials and they remain little more than potential attractive targets.
The Efficacy of RS-25259, a Long-Acting Selective 5-HT3 Receptor Antagonist, for Preventing Postoperative Nausea and Vomiting After Hysterectomy Procedures

We evaluated the safety and efficacy of RS-25259, a potent and long-acting selective 5-HT3 receptor antagonist, for the prevention of postoperative nausea and vomiting (PONV) in women undergoing hysterectomy procedures. In this randomized, double-blind, placebo controlled, dose-ranging study, 218 healthy, consenting women were assigned to one of the six treatment groups: placebo or RS-25259 0.1, 0.3, 1.0, 3.0, or 30 [micro sign]g/kg. All patients underwent a standardized general anesthetic technique. The study medication was administered IV 20-30 min before the end of surgery. During the initial 24-h period after surgery, the incidence of vomiting, the need for rescue antiemetics, the time to the first episode of emesis, and administration of rescue antiemetic medication, as well as a nausea visual analog scale and verbal categorical scale scores were recorded. In addition, recovery times from the end of anesthesia and the incidences of perioperative side effects were noted. Only 30 [micro sign]g/kg RS-25259 significantly decreased the incidence of vomiting and the requirement for rescue antiemetics. The largest dose of RS-25259 also delayed the time to the first emetic episode and reduced the number of treatment failures. However, no differences were found in the severity of postoperative nausea (versus saline), and postoperative headaches were more common after the administration of RS-25259 0.3-30 [micro sign]g/kg IV. In conclusion, RS-25259 30 [micro sign]g/kg IV was effective in reducing the incidence of PONV after major gynecologic surgery, but the occurrence of headaches with the larger doses of RS-25259 is a concern. Implications: RS-25259, a longacting 5-HT3 antagonist, was effective in reducing postoperative vomiting only at the largest dose studied (30 [micro sign]g/kg). However, RS-25259 had no antinausea activity, and the larger doses were associated with an increased incidence of headaches in the postoperative period. (Anesth Analg 1998;87:462-7)
Development of impact-based piezoelectric road energy harvester for practical application

Many researches with regard to piezoelectric energy harvesting from pressure exerted by passing cars have been conducted. In this paper, an impact-based road energy harvester as buried-type is developed with the method that the piezoelectric device is deformed directly by the pressure due to passing cars. Based on this, the developed road energy harvester is made to the size of 30 × 30 × 9 cm3. The performance of this new road energy harvester is measured with UTM (Universal Testing Machine) and MMLS3 (Third-scale Model Mobile Load Simulator) which can apply loads similar to the actual traffic loads to the harvester in lab-scale. Finally, the buried harvester is experimented with APT (Accelerated Pavement Testing).
A Study of the Effectiveness of Online Scarce Promotion - Based on the Comparison of Planned Buying and Unplanned Buying

Promotion can stimulate consumer’s unplanned buying which is regarded as the main source of sales growth, however, it may increase consumer’s planned buying shortfall as well. On one hand, online scarce promotion more significantly influences consumer’s unplanned buying and planned buying shortfall; On the other hand, frequent and continuing online promotion weakens its marginal performance. Under such circumstance, it becomes imperative for us to ascertain whether online scarce promotion can contribute to the growth of consumer’s purchases by comparing the effect of online scarce promotion on planned buying and unplanned buying. Our empirical analysis shows that online scarce promotion can decrease consumer’s planned buying shortfall, and also increase consumer’s unplanned buying, thus adding to consumer’s actual buying relative to their intended purchases.
Hospitals Known for Nursing Excellence Associated with Better Hospital Experience for Patients.

OBJECTIVE To examine the relationship between Magnet recognition, an indicator of nursing excellence, and patients' experience with their hospitalization reported in the Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey. DATA SOURCES This secondary analysis includes cross-sectional data from the 2010 HCAHPS survey, the American Hospital Association, and the American Nurses Credentialing Center. STUDY DESIGN We conducted a retrospective observational study. DATA COLLECTION Using common hospital identifiers, we created a matched set of 212 Magnet hospitals and 212 non-Magnet hospitals. PRINCIPAL FINDINGS Patients in Magnet hospitals gave their hospitals higher overall ratings, were more likely to recommend their hospital, and reported more positive care experiences with nurse communication. CONCLUSIONS Magnet recognition is associated with better patient care experiences, which may positively enhance reimbursement for hospitals.
May selective serotonin reuptake inhibitors (SSRIs) provide some benefit for the treatment of schizophrenia?

ABSTRACT Introduction: The treatment of some psychopathological dimensions of schizophrenia (e.g. negative and depressive symptoms) is still challenging for the modest efficacy of atypical antipsychotics. Among pharmacological alternatives, augmentative Selective Serotonin Reuptake Inhibitors (SSRIs) to antipsychotics are frequently prescribed in clinical practice to improve negative/depressive symptoms of schizophrenia patients; however, the data about the efficacy of these molecules on negative, depressive and obsessive-compulsive symptoms of schizophrenia are contrasting. Areas Covered: Research using the main database sources has been conducted to obtain an overview of the use and efficacy of SSRIs in schizophrenia. Expert Opinion: Data are too scanty to draw definitive recommendations. In a preliminary way, it can be said that available data do not show effectiveness of SSRIs on depressive symptoms of schizophrenia. Regarding negative symptoms, studies are contrasting, but paroxetine appears to be the most effective compound among SSRIs. Despite limited data, SSRIs appear to be useful for the treatment of obsessive-compulsive symptoms of schizophrenia, particularly fluvoxamine. Close clinical and pharmacological monitoring is needed in case of concomitant administration of antipsychotics and antidepressants for potential serious side effects and influence on plasma drug dosages
Sexual and reproductive health of adolescents in Belgium, the Czech Republic, Estonia and Portugal

Objectives This pilot study, within the REPROSTAT 2 Project, aimed at investigating the sexual and reproductive health (SRH) of school-based youths in four countries of the European Union. Methods Students of either sex, aged between 16 and 19 years and entering grade 10, 11 or 12 during the 2005–2006 school year participated in a cross sectional survey. A structured questionnaire was administered to a convenience sample of students from selected schools in Belgium, the Czech Republic, Estonia and Portugal. Results In each country, more than three quarters of respondents had previously had a boyfriend or girlfriend and almost half had heterosexual intercourse. More than 85% of sexually experienced youths in each country had used contraception at coital debut. Mean age at coital debut varied between 15.2 (Belgium) and 16.4 years (Czech Republic). While 51% of respondents in Estonia knew of Chlamydia trachomatis infection, the corresponding figure in Portugal was only 12%. Conclusions Sexual activity is common among school-going youths in all four countries. This highlights the need for Member States to systematically collect indicators of SRH in this population. Use of a common measurement framework can inform the establishment of common targets for joint initiatives such as reducing teenage pregnancy and STIs in adolescents.
Directional budding of human immunodeficiency virus from monocytes

Time-lapse cinematography revealed that activated human immunodeficiency virus (HIV)-infected monocytes crawl along surfaces, putting forward a leading pseudopod. Scanning electron micrographs showed monocyte pseudopods associated with spherical structures the size of HIV virions, and transmission electron micrographs revealed HIV virions budding from pseudopods. Filamentous actin (F-actin) was localized by electron microscopy in the pseudopod by heavy meromyosin decoration. Colocalization of F-actin and p24 viral antigen by light microscopy immunofluorescence indicated that F-actin and virus were present on the same pseudopod. These observations indicate that monocytes produce virus from a leading pseudopod. We suggest that HIV secretion at the leading edges of donor monocytes/macrophages may be an efficient way for HIV to infect target cells.