Miracle-dz/UniFAR-FTUs huggingface dataset:
Stokes problems for moving half-planes

New exact solutions of the Navier–Stokes equations are obtained for the unbounded and bounded oscillatory and impulsive tangential edgewise motion of touching half-infinite plates in their own plane. In contrast to Stokes classical solutions for the harmonic and impulsive motion of an infinite plane wall, where the solutions are separable or have a simple similarity form, the present solutions have a two-dimensional structure in the near region of the contact between the half-infinite plates. Nevertheless, it is possible to obtain relatively simple closed-form solutions for the flow field in each case by defining new variables which greatly simplify the r- and θ-dependence of the solutions in the vicinity of the contact region. These solutions for flow in a half-infinite space are then extended to bounded flows in a channel using an image superposition technique. The impulsive motion has application to the motion near geophysical faults, whereas the oscillatory motion has arisen in the design of a novel oscillating half-plate flow chamber for examining the effect of fluid shear stress on cultured cell monolayers.
Toxicity of Industrially Relevant Chlorinated Organic Solvents In Vitro

The cytotoxic effects of 4 industrially important chlorinated organic solvents, dichloromethane (DCM), 1,2-dichloroethane (DCE), trichloroethylene (TCE), and tetrachloroethylene (PERC) in vitro, were investigated. Jurkat T cells were exposed to the solvents individually for 72 hours and changes in reactive oxygen species (ROS) formation, cell proliferation, intracellular free calcium concentration ([Ca2+]), and caspase-3 activity were measured. There was a concentration-dependent increase in the ROS formation and intracellular free [Ca2+] following exposure to each of the solvents. This was accompanied by a decrease in the cell proliferation. Solvent potency decreased in the following order: PERC > TCE > DCM > DCE. Caspase-3 activity was increased in a concentration-dependent manner by TCE and PERC but was not significantly altered by DCM or DCE. n-Acetyl-l-cysteine pretreatment showed that changes in the intracellular free [Ca2+] and caspase-3 activity were independent of ROS formation. However, increased ROS formation did play a causal role in the decreased cell proliferation observed.
Drug Susceptibility and Molecular Epidemiology of Pseudomonas aeruginosa Isolated in a Burn Unit

Problem statement: Pseudomonas aeruginosa is an opportunistic pathogen that still develops life-threatening infections in patients with immunological system defects, like burn patients, especially in developing countries. Since this bacterium is naturally resistant to many drugs and is able to get resistance to all effective antibiotics, the infection with this organism is particularly problematic condition for patients. This study was design to evaluated drug susceptibility for determination of multidrug-resistant isolates and molecular epidemiology of P. aeruginosa colonization for investigation of the isolates routes in the burn unit of Shahid Motahhari Hospital in Tehran. Approach: About 127 clinical and 2 environmental P. aeruginosa isolates were collected during 6 months. All P. aeruginosa isolates were analyzed for drug susceptibility by disk diffusion method and molecular epidemiology assessment were done by RAPD-PCR analysis. Results: Drug susceptibility tests were shown high resistance for ceftizoxime (86.8%), aztreonam (80.6%), kanamycin (79.8%) and tetracycline (78.3%); furthermore, low resistance for some antibiotics like imipenem (30.2%), piperacillin/tazobactam (34.1%) and amikacin (41.1%) was showed. In addition, 42 multidrug-resistant P. aeruginosa isolates were recovered from clinical specimens and one isolate from environmental samples. Molecular typing revealed eight different profiles that include two profiles, RAPD1 and RAPD4, with environmental resource. The major RAPD profile was RAPD1 profile (n = 64, 50.4%), which includes 31 (72.1%) multidrug-resistant isolates with an environmental reservoir. Conclusion: In summery, we were found three different profiles for multidrug-resistant strains. Different RAPD profiles suggested the different resources of infection, two environmental resources were found, that one of them was multidrug-resistant strain. These findings highlighted the need for further attention to disinfection inanimate hospital environment and controlled contact between staff with patients to limit transfer of P. aeruginosa in this BU; moreover, use of some antimicrobial agents must be restricted due to existence of high resistance and using of combined effective antibiotics is recommend.
p38 Mitogen‐Activated Protein Kinase Activity Commits Embryonic Stem Cells to Either Neurogenesis or Cardiomyogenesis

Mouse embryonic stem (ES) cells can be differentiated, in vitro into a variety of cell types including cardiac cells and neurons. This process is strictly controlled by the potent morphogen retinoic acid (RA). At a concentration of 10−7 M, RA induces ES cell differentiation into neurons and, conversely, inhibits cardiomyogenesis. We found that p38 mitogen‐activated protein kinase (p38MAPK) activity peaked spontaneously, between day 3 and day 5, during ES cell differentiation and that RA completely inhibited this peak of activity. In contrast to wild‐type cells, which required RA treatment, p38α −1− ES cells differentiated spontaneously into neurons and did not form cardiomyocytes. Moreover, inhibition of the peak of p38MAPK activity by a specific inhibitor, PD169316, committed ES cells into the neuronal lineage and blocked cardiomyogenesis. By genetic and biochemical approaches, we demonstrate that, in two different ES cell lines, the control of p38MAPK activity constitutes an early switch, committing ES cells into either neurogenesis (p38 off) or cardiomyogenesis (p38 on).
Investigating trainee translators’ views on the pronunciation of English: a Slovene perspective

While the importance of excellent pronunciation skills for language professionals is indisputable, research attention has focused mainly on the pronunciation skills of teachers. Nevertheless translators, and even more so interpreters, who are constantly engaged in multi-lingual communication with their clients, face a tough competition in the global market and those with poor pronunciation skills are at a considerable disadvantage. Developing good pronunciation skills is thus an aspect that should not be neglected in the training of translators and interpreters, since it may directly affect their prospects of employment. The paper explores the views of Slovene trainee translators on the pronunciation of English. Their self-perception of English pronunciation skills and expectations concerning their pronunciation are examined by using a questionnaire administered to trainee translators at the University of Ljubljana. The questionnaire results provide an insight into the participants’ perceptions of their attained pronunciation proficiency and their attention to pronunciation instruction. The analysis of the replies reveals that trainee translators view pronunciation as an important element of their speaking proficiency, highlighting the issue of intelligibility as an essential component of communicative competence. The findings raise interesting issues important for pronunciation teaching in translator training, underlining the necessity to identify specific learner needs of future translators and interpreters.
Repeated isolation of Yersinia enterocolitica from pasteurized milk in a holding vat at a dairy factory.

Yersinia enterocolitica biotype 1 serotype 5a was repeatedly isolated from pasteurized milk in the same holding vat at a particular dairy factory. It is considered that the occurrence of this organism in pasteurized milk may be partially attributed to its ability to multiply at refrigeration temperatures and survive in inadequately ‘disinfected’ vats.
Erythroid Differentiation Sensitizes K562 Leukemia Cells to TRAIL-Induced Apoptosis by Downregulation of c-FLIP

ABSTRACT Regulation of the apoptotic threshold is of great importance in the homeostasis of both differentiating and fully developed organ systems. Triggering differentiation has been employed as a strategy to inhibit cell proliferation and accelerate apoptosis in malignant cells, in which the apoptotic threshold is often characteristically elevated. To better understand the mechanisms underlying differentiation-mediated regulation of apoptosis, we have studied death receptor responses during erythroid differentiation of K562 erythroleukemia cells, which normally are highly resistant to tumor necrosis factor (TNF) alpha-, FasL-, and TRAIL-induced apoptosis. However, upon hemin-mediated erythroid differentiation, K562 cells specifically lost their resistance to TNF-related apoptosis-inducing ligand (TRAIL), which efficiently killed the differentiating cells independently of mitochondrial apoptotic signaling. Concomitantly with the increased sensitivity, the expression of both c-FLIP splicing variants, c-FLIPL and c-FLIPS, was downregulated, resulting in an altered caspase 8 recruitment and cleavage in the death-inducing signaling complex (DISC). Stable overexpression of both c-FLIPL and c-FLIPS rescued the cells from TRAIL-mediated apoptosis with isoform-specific effects on DISC-recruited caspase 8. Our results show that c-FLIPL and c-FLIPS potently control TRAIL responses, both by distinct regulatory features, and further imply that the differentiation state of malignant cells determines their sensitivity to death receptor signals.
Motivation to become a teacher and its relationships with teaching self-efficacy , professional commitment and perceptions of the learning environment

With the present study we provide insight into the change that is and is not present after a year of teacher training in 58 pre-service teachers’ motivation to become a teacher, their professional commitment, and their self-efficacy. Furthermore, the extent to which these changes are related to these teachers’ perceptions of their learning environment, specifically their perceptions of the quality of curriculum, instruction, and assessment was investigated. These pre-service teachers completed a survey at the beginning and end of their teacher training. Their self-efficacy regarding their tasks within the broader school context significantly decreased during their training period. The pre-service teachers’ change in teachers’ motivation, professional commitment, and self-efficacy appeared to be unrelated to these teachers’ perceptions of their learning environment. Motivation to become a teacher 3 Motivation to become a teacher and its relationships with teaching self-efficacy, professional commitment and perceptions of the learning environment
Long bone articular and diaphyseal structure in old world monkeys and apes. I: locomotor effects.

The relationship between locomotor behavior and long bone structural proportions is examined in 179 individuals and 13 species of hominoids and cercopithecoids. Articular surface areas, estimated from linear caliper measurements, and diaphyseal section moduli (strengths), determined from CT scans, were obtained for the femur, tibia, humerus, radius, and ulna. Both within-bone (articular to shaft) and between-bone (forelimb to hindlimb) proportions were calculated and compared between taxa. It was hypothesized that: 1) species emphasizing slow, cautious movement and/or more varied limb positioning (i.e., greater joint excursion) would exhibit larger articular to cross-sectional shaft proportions, and 2) species with more forelimb suspensory behavior would have relatively stronger/larger forelimbs, while those with more leaping would have relatively stronger/larger hindlimbs. The results of the analysis generally confirm both hypotheses. Several partial exceptions can be explained on the basis of more detailed structural-functional considerations. Associations between locomotion and structural proportions can be demonstrated both across major groupings (hominoids and cercopithecoids) and between relatively closely related taxa, e.g., mountain and lowland gorillas, siamangs and gibbons, and Trachypithecus and other colobines. Furthermore, structure and function do not always covary with taxonomy. For example, compared to cercopithecoids, mountain gorillas have relatively larger joints, like other hominoids, but do not have relatively stronger forelimbs, unlike other hominoids. This is consistent with a locomotor repertoire emphasizing relatively slow movement but with very little forelimb suspension. Proportions of Proconsul nyanzae, Proconsul heseloni, Morotopithecus bishopi, and Theropithecus oswaldi are compared with modern distributions to illustrate the application of the techniques to fossil taxa.
Carbon dioxide versus normal saline in outpatient hysteroscopy.

BACKGROUND The aim of this prospective randomized study was to measure patients' discomfort after hysteroscopy with CO(2) or normal saline. METHODS A total of 415 patients was randomized to two groups according to distension medium (CO(2), n = 201; normal saline, n = 214). The nature of randomization was to alternate distension media on a weekly basis. After hysteroscopy, women were asked to rate the pain experienced on a 100-mm visual analogue scale (0 = no pain; 100 = worst imaginable pain). Pain scores were expressed as mean +/- SD (0-40 = minimal; 41-70 = moderate; 71-100 = severe). Data were analysed using Student's t-test. RESULTS Irrespective of the distension medium used, pelvic discomfort was worse in nulliparous women (pain score 39.0 +/- 26.5) than in multiparous women (30.4 +/- 25.9) (P < 0.05), especially if they were premenopausal. For all patients and both distension media, pelvic discomfort was generally minimal but higher in patients who had undergone hysteroscopy with normal saline (P < 0.05). CONCLUSIONS CO(2) and normal saline were comparable with regard to patient discomfort, but in terms of the high frequency of abnormal uterine bleeding, normal saline may be the most appropriate distension medium for outpatient hysteroscopy.
Çatışma Çözme Programının Ortaokul Öğrencilerinin Çatışma Çözüm Becerilerine, Sürekli Öfke ve Öfke İfade Tarzlarına Etkisi

Bu arastirmanin genel amaci, catisma cozme programinin, ortaokul ogrencilerinin catisma cozum becerileri, surekli ofke ve ofke ifade tarzlari uzerindeki etkisini incelemektir. Bu arastirma Milli Egitim Bakanligi'na bagli bir ortaokulda 2015-2016 egitim-ogretim yilinda yapilmistir. Deneme grubunda ve kontrol grubunda 12'ser ogrenci bulunmaktadir. Arastirmada on-test-son-test kontrol gruplu yari deneysel model kullanilmistir. Deney grubundaki ogrencilere haftada iki oturum olmak uzere bes hafta suresince catisma cozme psiko-egitim programi uygulanmistir. Kontrol grubunda yer alan ogrencilere ise herhangi bir egitim verilmemistir. Arastirmada veri toplamak icin Sari (2005) tarafindan gelistirilen ‘‘Catisma Cozumu Becerileri Olcegi’’ ve Ozer (1994) tarafindan Turkceye uyarlanan ‘‘Surekli Ofke ve Ofke Ifade Tarzi Olcegi’’ kullanilmistir. Deneme ve kontrol grubunun on-test son-test fark puanlarinin anlamliligi icin Mann Whitney U testi kullanilmistir. Arastirma sonucunda elde edilen bulgulara gore; ergenlere uygulanan catisma cozme programinin ergenlerin butunlesme ve uyma puanlarini artirmada; hukmetme puanlarini dusurmede etkili oldugu sonucuna varilmistir. Ayrica catisma cozme psiko-egitim programi uygulanan ogrencilerin surekli ofke duzeylerini, ice yonelik ofke tarzi ve disa yonelik ofke tarzi puanlarini dusurmede; ofke kontrol puanlarini ise artirmada etkili oldugu belirlenmistir.
A wearable ear-EEG recording system based on dry-contact active electrodes

This work reports an ear-EEG acquisition system with dry-contact active electrodes for future wearable applications. Employing dedicated chopper buffer in the active electrodes, a prototype fabricated in a 0.18-μm CMOS demonstrates input impedance as large as 18GΩ@DC and 6. 7GΩ@50Hz, and 3.03fA/vHz input current noise, and a total input-referred noise (IRN) of 0. 67μVrms in 0.5-100Hz bandwidth. System's CMRR in combination with active electrodes is higher than 100dB@DC. Under large source impedance imbalance of 1MΩ, a 78-dB@50Hz CMRR is still obtained. To validate the system's ability to record EEG, an auditory stead-state response was measured, showing same SNR with wet electrodes and a commercial EEG amplifier.
Modification of solid lipid nanoparticles loaded with nebivolol hydrochloride for improvement of oral bioavailability in treatment of hypertension: polyethylene glycol versus chitosan oligosaccharide lactate

Abstract Nebivolol (NB)-loaded solid lipid nanoparticles (SLNs) were prepared and modified with chitosan oligosaccharide lactate (COL) and polyethylene glycol (PEG) stearate for improvement of its oral bioavailability. Compritol, poloxamer and lecithin were used for the preparation of SLNs by homogenisation method. After in vitro characterisation effect of lipase, pepsin, or pancreatin on degradation and release rate were investigated. Cytotoxicity and permeation were studied on Caco-2 cells. As COL concentration increased in SLNs, size and zeta potential increased. PEG concentration was reversely proportional to particle size with no change in zeta potential. Encapsulation efficiencies (EEs) were determined as 84–98%. DSC confirmed solubilisation of NB in lipid matrix. A sustained release with no burst effect was determined. The presence of enzymes affected the release. SLNs did not reveal cytotoxicity and highest permeability was obtained with PEG modification. PEG-modified SLNs could be offered as a promising strategy for oral delivery of NB.
Frustrated and invisible--younger stroke patients' experiences of the rehabilitation process

Purpose : This study aimed to get knowledge of the younger stroke patient's viewpoint and to describe how young stroke patients experience the rehabilitation process. The purpose was also to develop hypotheses about the relationship between young stroke patients and the rehabilitation process. Method : Thematised in-depth interviews were performed with two women and three men who suffered from stroke (37 v - v 54 years). The analysis used was the Grounded Theory method of constant comparison. Results : The analyses resulted in the core category 'Frustration' which was derived from the categories labelled 'The paralysed everyday' and 'Outside and invisible'. 'The paralysed everyday' category involved different aspects of everyday life after a stroke. Because of their fatigue they were unable to work and their family and social life were negatively affected. They found it difficult to engage in daily life activities and felt indifferent. The three women expressed frustration over the demands they experienced as being mothers and housekeepers, whereas the two men emphasised economic responsibility of the family as problematic. The category 'Outside and invisible' describes the lack of participation the informants experienced regarding the rehabilitation process. The informants felt they lacked information and age-adapted interventions. Their needs were not provided for and they felt distant from the other patients. Their remaining symptoms were probably on a cognitive basis and therefore invisible. This was a source of frustration. Conclusion : The hypotheses generated indicated that young stroke patients are frustrated and invisible due to the fact that the rehabilitation setting does not acknowledge the different needs of young stroke patients compared with older patients.
Contextual imitation of intransitive body actions in a Beluga whale (Delphinapterus leucas): A “do as other does” study

Cetaceans are remarkable for exhibiting group-specific behavioral traditions or cultures in several behavioral domains (e.g., calls, behavioral tactics), and the question of whether they can be acquired socially, for example through imitative processes, remains open. Here we used a “Do as other does” paradigm to experimentally study the ability of a beluga to imitate familiar intransitive (body-oriented) actions demonstrated by a conspecific. The participant was first trained to copy three familiar behaviors on command (training phase) and then was tested for her ability to generalize the learned “Do as the other does” command to a different set of three familiar behaviors (testing phase). We found that the beluga (1) was capable of learning the copy command signal “Do what-the-other-does”; (2) exhibited high matching accuracy for trained behaviors (mean = 84% of correct performance) after making the first successful copy on command; (3) copied successfully the new set of three familiar generalization behaviors that were untrained to the copy command (range of first copy = 12 to 35 trials); and (4) deployed a high level of matching accuracy (mean = 83%) after making the first copy of an untrained behavior on command. This is the first evidence of contextual imitation of intransitive (body-oriented) movements in the beluga and adds to the reported findings on production imitation of sounds in this species and production imitation of sounds and motor actions in several cetaceans, especially dolphins and killer whales. Collectively these findings highlight the notion that cetaceans have a natural propensity at skillfully and proficiently matching the sounds and body movements demonstrated by conspecifics, a fitness-enhancing propensity in the context of cooperative hunting and anti-predatory defense tactics, and of alliance formation strategies that have been documented in these species’ natural habitats. Future work should determine if the beluga can also imitate novel motor actions.
Invariant funnels for underactuated dynamic walking robots: New phase variable and experimental validation

We address the problem of finding useful invariant funnels for dynamic walking robots, i.e. sets of initial conditions from which continued walking in a stable manner is guaranteed. The construction is based on transverse dynamics and sum-of-squares verification. This paper makes two main contributions: firstly, we show that for typical models of walking robots the construction of such funnels can be significantly simplified by use of a new phase variable. Secondly, we provide the first hardware validation of the resulting funnels on an experimental testbed.
Detecting Dutch Political Tweets: A Classifier based on Voting System using Supervised Learning

The task of classifying political tweets has been shown to be very difficult, with controversial results in many works and with non-replicable methods. Most of the works with this goal use rule-based methods to identify political tweets. We propose here two methods, being one rule-based approach, which has an accuracy of 62%, and a supervised learning approach, which went up to 97% of accuracy in the task of distinguishing political and non-political tweets in a corpus of 2.881 Dutch tweets. Here we show that for a data base of Dutch tweets, we can outperform the rule-based method by combining many different supervised learning methods.