Miracle-dz/UniFAR-FTUs huggingface dataset:
Uric acid metabolism in psoriasis.

control subjects. The patient with gout and psoriasis (F.M.) had a history of frequent attacks of acute arthritis which responded to colchicine. A synovial biopsy of his left knee revealed characteristic deposition of urate crystals. The control subjects had no family history or stigmata of either psoriasis or gout. Remission of psoriasis occurred in one patient (L.P.) following a severe drug eruption resulting from the oral administration of chloroquin phosphate. Within 2 weeks after the drug had been discontinued, complete healing of the skin had occurred and no lesions of psoriasis were present. The repeat glycine-1-C1' incorporation study was carried out approximately 10 weeks after the last dose of chloroquin had been administered, while the psoriasis was still in complete remission. All subjects were hospitalized throughout the studies and were maintained on a standard 2,600 calorie diet, essentially free of purines and containing 70 g of protein, 350 g of carbohydrate and 100 g of fat. At least 5 days were allowed for equilibration on the diet before the studies were performed. Patients received no medication during the study. The clinical diagnosis of psoriasis in each case was confirmed by skin biopsy. Renal function was assessed by routine urinalysis, blood urea nitrogen and phenolsulfonphthalein excretion. Daily 24-hour urine collections were preserved with
Field-dependent thermoelectric power and thermal conductivity in multilayered and granular giant magnetoresistive systems.

The giant magnetoresistance (GMR) effect in granular and multilayer thin films has been widely investigated because of possible device applications. Despite this intensive effort, the underlying mechanisms responsible for the effect have not been identified. We present measurements of the thermoelectric power (TEP) and thermal conductivity on a wide variety of granular and multilayer GMR systems. The strong magnetic field dependences of both the TEP and the thermal conductivity are found to be closely related to the magnetoresistance. The TEP measurements require that the high density of states in the ferromagnetic materials play a major role in the GMR effect. The thermal conductivity measurements indicate that the scattering mechanisms in granular samples are elastic while multilayer samples have a significant inelastic, spin-flip component. {copyright} {ital 1996 The American Physical Society. }
Cellular senescence increases expression of bacterial ligands in the lungs and is positively correlated with increased susceptibility to pneumococcal pneumonia

Cellular senescence is an age‐associated phenomenon that promotes tumor invasiveness owing to the secretion of proinflammatory cytokines, proteases, and growth factors. Herein we demonstrate that cellular senescence also potentially increases susceptibility to bacterial pneumonia caused by Streptococcus pneumoniae (the pneumococcus), the leading cause of infectious death in the elderly. Aged mice had increased lung inflammation as determined by cytokine analysis and histopathology of lung sections. Immunoblotting for p16, pRb, and mH2A showed that elderly humans and aged mice had increased levels of these senescence markers in their lungs vs. young controls. Keratin 10 (K10), laminin receptor (LR), and platelet‐activating factor receptor (PAFr), host proteins known to be co‐opted for bacterial adhesion, were also increased. Aged mice were found to be highly susceptible to pneumococcal challenge in a PsrP, the pneumococcal adhesin that binds K10, dependent manner. In vitro senescent A549 lung epithelial cells had elevated K10 and LR protein levels and were up to 5‐fold more permissive for bacterial adhesion. Additionally, exposure of normal cells to conditioned media from senescent cells doubled PAFr levels and pneumococcal adherence. Genotoxic stress induced by bleomycin and oxidative stress enhanced susceptibility of young mice to pneumonia and was positively correlated with enhanced p16, inflammation, and LR levels. These findings suggest that cellular senescence facilitates bacterial adhesion to cells in the lungs and provides an additional molecular mechanism for the increased incidence of community‐acquired pneumonia in the elderly. This study is the first to suggest a second negative consequence for the senescence‐associated secretory phenotype.
A Typology of Individual Search Strategies Among Purchasers of New Automobiles

Cluster analysis of questionnaire data was used to identify six distinctive external information search patterns among purchasers of new automobiles. Two of the shopper clusters had not been clearly specified in prior research—namely, an advisor-assisted shopper group and a highly self-reliant shopper group. An effort to cross-validate the typology using data obtained from automobile sales personnel was partially successful. It is hypothesized that these strategies are reflections of heuristic decision processes which reflect both individual difference characteristics and the purchase situation.
EFFECT OF EXCLOSURE ON RUNOFF, SEDIMENT CONCENTRATION AND SOIL LOSS IN EROSION PLOTS

Nowadays watershed and rangeland management projects play the important role in water resources and soil management worldwide. Although watershed and rangeland management projects have the considerable importance as approaches to rural areas development and natural resources management, more studies have been focused on their effects on sediment and their effects on soil erosion have rarely been considered. The present study was conducted in two treated and control sub-watersheds with exclosure treatment and under grazing respectively, in Khamsan representative watershed with an area of 4337.27 ha in south of Kurdistan Province, Iran. Three plots were installed in each western, northern and eastern slopes for the runoff volume and coefficient, sediment concentration and soil loss measurement. The exclosure treatment was operated for installed plots in treated sub-watershed from 2007. Then, all the data of runoff volume and coefficient, sediment concentration and soil loss from USLE standard plots in both control and treated sub-watersheds for 52 events over the years 2009 to 2014 were compared and evaluated. Therefore, in order to the number of plots and subwatersheds, 18 USLE standard plot data were finally recorded and analysed for each storm event. The results showed the significant (p≤0.05) decreasing effect of exclosure treatment on runoff volume, sediment concentration and soil loss at plot scale. Finally, decreasing rates of 15.68, 6.13, 16.67, 24.37 and 21.43% due to exclosure respectively for runoff volume and coefficient, sediment concentration, soil loss and sediment yield were obtained. The variables of runoff volume, soil loss and sediment yield had statistically significant differences (p≤0.05) in treated and control sub-watersheds. The sediment concentration variable had p value of 0.058 and therefore the effect of exclosure treatment on sediment concentration was also significant (p≤0.06).
A framework of outsourcing relationship marketing: a focus on the Malaysian hotel industry

This study contributes to the body of knowledge by examining the antecedents of outsourcing relationship quality among the management of Malaysian hotels and their service providers. This study is important considering that the quality of relationship between client firms and their service providers adds positive image to the entire system and is crucial for the delivery of the benefits of outsourcing arrangement. Identifying the determinants of the outsourcing relationship quality is important due to its effect on outsourcing ventures. A firm should have a strong relationship with its service provider since a high relationship quality has been proven to provide positive impact on outsourcing. This study examines the effect of relational norms on the quality of relationship among hotel managements and their service providers. Hotel industry has been the focus of this study due to its significant contribution to the service sector as the largest contributor of the Malaysian economy.
Biochemical and Functional Properties of Wheat Gliadins: A Review

Gliadins account for 40–50% of the total storage proteins of wheat and are classified into four subcategories, α-, β-, γ-, and ω-gliadins. They have also been classified as ω5-, ω1, 2-, α/β-, and γ-gliadins on the basis of their primary structure and molecular weight. Cysteine residues of gliadins mainly form intramolecular disulfide bonds, although α-gliadins with odd numbers of cysteine residues have also been reported. Gliadins are generally regarded to possess globular protein structure, though recent studies report that the α/β-gliadins have compact globular structures and γ- and ω-gliadins have extended rod-like structures. Newer techniques such as Mass Spectrometry with the development of matrix-assisted laser desorption/ionization (MALDI) in combination with time-of-flight mass spectrometry (TOFMS) have been employed to determine the molecular weight of purified ω- gliadins and to carry out the direct analysis of bread and durum wheat gliadins. Few gliadin alleles and components, such as Gli-B1b, Gli-B2c and Gli-A2b in bread wheat cultivars, γ-45 in pasta, γ-gliadins in cookies, lower gliadin content for chapatti and alteration in Gli 2 loci in tortillas have been reported to improve the product quality, respectively. Further studies are needed in order to elucidate the precise role of gliadin subgroups in dough strength and product quality.
Corporate Lobbying and Fraud Detection: Revisited

This paper re-examines the size of penalties following securities class actions and the impact of lobbying on the time it takes to detect managerial misconduct. Managers of lobbying firms are able to get away with misconduct for longer and are marginally less likely to have to settle a class action up to 2004. From 2005, lobbying no longer impacts the time it takes to detect misconduct or the outcome of the case. Our findings suggest that the tacit power of lobbying firms has decreased over time and the most likely explanation for this is the enactment of SOX.
Why Do IPO Offer Prices Only Partially Adjust?

This study develops a structural model of the initial public offering (IPO) pricing process that enables the estimation of adjustment rates for public and private pricing information gathered during bookbuilding. The estimated upward adjustment rate of public information is only 21%, significantly less than the 28% rate of private information. Adjustment rates decline towards the IPO date, especially for upward adjustments. The findings contradict information acquisition theories that predict a complete adjustment to public information and highlight the inefficiency of the IPO bookbuilding mechanism in handling new information even when information is publicly available and especially when it is favorable.
Secondhand smoke does cause respiratory disease

Editor–The report by Enstrom and Kabat confirms that exposure to secondhand smoke causes injury to the respiratory system with the finding of a combined increased mortality risk for men and women for chronic obstructive pulmonary disease (relative risk 1.65, 95% confidence interval 1.0 to 2.73). 1 This is consistent with other investigations that show the sensitivity of the respiratory system to secondhand smoke at all ages and in different settings. In …
Privacy concern and online transactions: the impact of internet self-efficacy and internet involvement

Purpose – This study aims to examine the effects of internet self-efficacy and internet involvement on privacy concern and the effect of privacy concern on the frequency of online transactions. The study also seeks to examine the direct effect of internet self-efficacy and internet involvement on the frequency of online transactions. Design/methodology/approach – A structural equation model was developed to test the hypotheses. The model was tested using the LISREL 8.8 software and both structural and measurement parameters were estimated. Findings – Findings suggest that internet self-efficacy and internet involvement affect privacy concern negatively; and privacy concern, in turn, affects frequency of online transactions negatively. Findings also indicate that the direct effect of internet self-efficacy and internet involvement on the frequency of online transactions is positive. All parameters are significant and in the hypothesized direction. Practical implications – Findings highlight the significanc.
Factors Influencing Generations Y students’ Attitude towards Online Shopping

Internet access grew exponentially in South Africa; online shopping in South Africa has also shown an upward trend, although it is still in its infancy. Generation Y consumers, and students in particular, spend more time on the internet and are regarded as the most attractive market segments for online shopping. Their spending power exceeds those of their parents. Marketers should, therefore, understand factors that determine the Generation Y students’ attitude towards online shopping. A survey method, using convenience sampling, was adopted to study the attitude of Generation Y students towards online shopping. A closed-ended questionnaire was distributed among the Generation Y students at a university of technology. The outcomes of the study indicated that the majority of Generation Y students do not shop online. However, the Generation Y students spend more time on the Internet, accessing the Internet on a daily basis. The Generation Y students at different age groups did not differ in attitudes towards online shopping. Generation Y students were found to be influenced by the perceived convenience associated with online shopping. DOI: 10.5901/mjss.2014. v5n21p39
Partner Selection in Emerging and Developed Market Contexts: Resource-Based and Organizational Learning Perspectives

This study of the international partner selection of firms from emerging (Mexico, Poland, and Romania) and developed (Canada, France, and the United States) markets supports resource-based and organizational learning explanations of such partner selection, a critical factor for success with international strategic alliances. Emerging market firms emphasized financial assets, technical capabilities, intangible assets, and willingness to share expertise in selection of partners more than developed market firms. In contrast, developed market firms tried to leverage their resources through partner selection. In particular, they emphasized unique competencies and local market knowledge and access in their partner selection more than emerging market firms.
The determinants of increased short-selling activity

Using hedge fund assets and institutional ownership (IO) as proxies for short-selling demand and supply, this paper investigates the determinants of increased short-selling activity on the NYSE/AMEX and NASDAQ from 1988 to 2011. Hedge fund assets, IO and liquidity are significantly related to short-selling activity, and the relationships are stronger in the 2001-2011 period than in the 1988-2000 period. The ownership of short-term hold institutions has a stronger relationship with short-selling activity than ownership of long-term hold institutions. Further, both the expected and unexpected components of short selling have stronger relationships with short-term IO than with long-term IO.
BUSINESS MODEL ANALYSIS ON ANDROID APP STORES

Heikkinen, Lauri Business model analysis on Android app stores Jyvaskyla: University of Jyvaskyla, 2013, 103 p. Information Systems, Master’s Thesis Supervisor: Frank, Lauri The recent growth in smart phone and tablet adoption has increased the popularity of mobile application stores, also known as app stores. This study examines the business models and underlying strategic factors of the app stores operating in the Android ecosystem. The study consists of a literature review on business models, two-sided markets and platforms, followed by a multiple-case study researching six Android app stores. The app store features and policies implemented by the studied app stores are analyzed in order to draw implications on business models and the underlying strategies. Effectively all of the app store’s revenues come from the revenue share retained from the developers. Due to this dependency on the developers, app stores aim to provide tools that improve the monetization possibilities for the applications. Moreover, these tools and the revenues attained by using them are protected by certain policies and regulating processes exerted by the app stores. Furthermore, the device integration of the app store appears to be an important channel for the studied app stores to reach the users. Finally, developer aimed APIs and SDKs provided by the app stores stand out as an important strategic and competitive factor.
Erratic strategic decisions: when and why managers are inconsistent in strategic decision making

While decision makers in organizations frequently make good decisions rooted in stable and consistent preferences, such consistency in outcomes is not always the case. In this study, we adopt a psychological perspective of judgment to investigate managers' erratic strategic decisions, which we define as a manager's inconsistent judgments that can shape the direction of the firm. In a study of 2,048 decisions made by 64 CEOs of technology firms, we examine how both metacognitive experience and perceptions of the external environment (hostility and dynamism) could affect the extent to which managers make erratic strategic decisions. The results indicate that managers with greater metacognitive experience make less erratic strategic decisions. The results also indicate that in hostile environments managers make more erratic strategic decisions. But contrary to our expectations, in dynamic environments managers make less erratic strategic decisions. Similarly, hostility and dynamism interact in their effect on erratic strategic decisions in that the positive relationship between environmental hostility and erratic strategic decisions will be less positive for managers experiencing high environmental dynamism than those experiencing low environmental dynamism. These results have important implications for strategic decision-making research. Copyright © 2010 John Wiley & Sons, Ltd.
Short Stature and Turner Skeletal Features in an 11-Year-Old Boy with a Ring Y Chromosome Missing the Short Stature Homeobox Containing Gene

We report on an 11-yr-old boy with short stature and Turner skeletal features. Chromosome analysis revealed a 46,X,r(Y)(p11.3q11.2) karyotype, and FISH analysis showed loss of the Short stature homeobox containing gene (SHOX) from the ring Y chromosome. The results are consistent with the association of SHOX haploinsufficiency with short stature and Turner skeletal features, and suggest the importance of SHOX analysis in boys with Turner-like skeletal phenotype.
Towards a More Holistic Stakeholder Analysis Approach. Mapping Current And Potential Stakeholders From Social Media.

This paper proposes a conceptual direction for organizations of how they could map their stakeholders in a more holistic way. Thesis suggests that stakeholder theory is useful in identifying and prioritizing stakeholders that a company is aware of. However, the theory is argued being ineffective in finding stakeholders on new environments (social media), where connectivity and relationships play a key role. As addressed by Rowley (1997), stakeholder theory dismisses relationships that go beyond dyadic ties. As a consequence, new approaches should be used to properly map stakeholders from social media. This research paper proposes social network analysis (SNA) being suitable for analyzing social media. Moreover, SNA is argued being crucial in finding key actors within the network that particular company is not necessarily aware of. These actors are argued being important to identify since, they can be great intermediaries in communicating important information regarding a company or e.g. help preventing to cope with different crisis situations respectively (Coombs, 2008). As a consequence, they can be vital stakeholders of the company. Therefore, the importance of identifying them is considered being relevant. A process of finding these social media members (stakeholders among others) is identified incorporating SNA. Analysis includes estimating key network characteristics such as Density (see part 2.3.1.3.3). In addition, the process of social media stakeholder identification suggests judging certain actor presence within social media network based on its Prestige and various Centrality measures presented in parts 2.3. 1.3 accordingly. Centrality indices (see part 2.3) are argued being vital in finding important network actors (potential stakeholders) since it is proposed, that being connected to badconnected others makes an actor “powerful” (Hanneman, & Riddle, 2005) or that having many connections refers to a greater possibility to reach other members of the network. The combination of stakeholder theory and SNA is proposed as a more holistic solution for stakeholder mapping including those from social media (that company is not necessarily aware of).
A measure of ceo social power in strategic decision‐making

For the strategic management field to advance its understanding of the interpersonal dimensions of strategic decision‐making, valid and reliable measures of power and influence need to be developed. Research in the discipline would also be subsequently likely to enjoy enhanced viability and greater cross‐discipline confidence if it was based on proven measures. For these reasons, field research was undertaken to determine if a modified version of an existing instrument (Spekman, 1979), designed to gauge social power at low organizational levels, could be used to measure the exercise of CEO power in strategic decision‐making.
Transaction Costs in Agriculture: From the Planting Decision to Selling at the Wholesale Market: A Case-Study on the Feeder Area of the Dambulla Dedicated Economic Centre in Sri Lanka

With the increasing concern with regards to reducing poverty in the world, lowering transaction costs within the value chain is one of the key elements to ensuring growth in agriculture which will in turn have a significant impact in reducing poverty. This paper presents the results of a study to identify the information-related transaction costs of selected small-holder farmers who sell their produce at Sri Lanka’s largest wholesale agriculture market. It then analyses the potential reduction of these costs if they were to use Information and Communication Technology (ICT) tools in obtaining such information.This study finds that information related costs form 70 percent of the total transaction costs, which is 15 percent of the total production cost, incurred by these farmers. Therefore, it is argued that simple mobile phones can reduce these costs significantly. Such information can help farmers not only in deciding where and at what price to sell their produce, but also in reducing the high search costs associated with locating outlets that has (subsidized) fertilizer available for distribution on a given day.Overall, it is postulated that benefits to farmers can become much greater if a phone-based ICT platform could tie the selling decision with that of the decision to grow a particular produce while incorporating information needs of the farmer throughout the value chain. It is believed that this a reasonable approach because the mobile phone is expected to reach 90 percent of the world’s population by 2010 (GSMA, 2006), including these farmers.