Miracle-dz/UniFAR-FTUs huggingface dataset:
Mean stream coordinates structure of the Subantarctic Front: Temperature, salinity, and absolute velocity

[1] The mean synoptic structure of the northern, strongest branch of the Antarctic Circumpolar Current southwest of Tasmania, at the Subantarctic Front (SAF), is estimated by a stream coordinates analysis of data from overlapping arrays of Inverted Echo Sounders (IESs) and Horizontal Electric Field Recorders deployed during the 1995–1997 Sub-Antarctic Flux and Dynamics Experiment. The stream coordinates are derived from a daily objective mapping of the temperature field obtained from combining the IES travel time measurements with an empirical look-up table constructed from the extensive hydrography acquired during WOCE. Full-water-column stream-coordinates sections of temperature, Salinity, and absolute velocity are presented and compared with prior observations. The along-stream current has a single peak with surface velocities reaching about 50 cm s−1. The vertical structure of the along-stream velocity is roughly consistent with a combined external and first internal normal mode description that is adapted to the buoyancy frequency as it varies across the front, although there are some significant differences. The cross-stream structure of along-stream velocity is very nearly symmetric about the jet axis, but the lateral shear magnitude is slightly larger on the cold side of the SAF. Separating the baroclinic and barotropic currents reveals that the SAF currents are diffluent, primarily baroclinically, in the cross-stream direction. Baroclinic cross-stream diffluence of approximately 0.23 Sv per km (Sv = 106 m3 s−1), or about 16 Sv per degree of longitude at 51°S. The 2-year mean total SAF transport is 75 Sv (for a 220 km width); the barotropic contribution is small (8 Sv) but not negligible.
Compact UWB Band-Notched Antenna Design Using Interdigital Capacitance Loading Loop Resonator

In this letter, a new compact ultrawideband (UWB) antenna with band-notched characteristic is proposed for UWB communication applications. By using a C-shaped ground, the overall dimension of the proposed antenna is dramatically decreased to 24 × 28 × 1 mm3. To avoid potential interferences, interdigital capacitance loading loop resonator (IDCLLR) is utilized to reject certain bands within the passband of the antenna. Due to its high capacitance, the resonator has a smaller size and forms a narrower notched band than many other structures, thus the present design effectively saves many more useful frequencies. Good agreement is achieved between the simulation and measurement, which shows that the proposed antenna has an operation frequency band from 3 to 13 GHz with good rejection to the wireless local area network bands (WLANs) (5.2- and 5.8-GHz bands).
Neurokinin3 receptor antagonism attenuates cocaine's behavioural activating effects yet potentiates its dopamine‐enhancing action in the nucleus accumbens core

Several lines of evidence indicate a role for neurokinin3 receptors (NK3‐Rs) in behavioural activation and mechanisms governing reinforcement processes. In this study we investigated the effect of pretreatment with the NK3‐R antagonist, SR142801, (0.2 and 2.0 mg/kg) on the cocaine‐induced (10.0 mg/kg i.p.) increase in extracellular dopaminergic activity in the nucleus accumbens (NAc). In vivo microdialysis in the NAc of freely moving rats showed that cocaine increased concentrations of dopamine (DA) to ∼350% in the core and ∼450% in the shell. Pre‐treatment with SR142801 significantly potentiated this effect in the core (to ∼550%), whereas this effect was not found in the shell. We also investigated the effects of NK3‐Rs antagonism on cocaine‐induced hyperactivity and conditioned place preference. SR142801 blocked the hyperactivity, but neither the conditioned place preference nor the conditioned locomotor activity induced by cocaine, although there was a slight tendency towards a reduced place preference. When given alone, SR142801 had no effects on behaviour or extracellular dopamine concentrations in any of the structures investigated. These data provide evidence for a contribution of NK3‐Rs in the acute behavioural and neurochemical effects of cocaine, involving dopaminergic activity in the core of the nucleus accumbens.
Conversion disorder in childhood--diagnosed too late, investigated too much?

Conversion disorder is defined in the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)1 as a condition in which symptoms and deficits in voluntary motor function suggest a neurological or other physical condition which is in fact not present. Child psychiatrists have reported a prevalence of 1–3% in the patients they see.2,3 Among new outpatients at a paediatric neurology unit in the west of England the prevalence is closer to 10%. These cases place considerable demands on consulting time and diagnostic resources. In this paper a case is made for early recognition and for management by the general paediatric team.
[Nasopharyngeal carriage of Streptococcus pneumoniae in healthy children, 2 to 24 months of age, in New-Caledonia].

OBJECTIVES The aims of this study were to determine the prevalence of pneumococcal nasopharyngeal carriage in New-Caledonian children less than two years of age, to define risk factors for carriage, and to document the serotypes present in New Caledonia prior to the implementation of the conjugate pneumococcal vaccine. METHOD AND RESULTS From August 2002 to April 2003, nasopharyngeal samples were collected on 1040 children less than two years of age during scheduled visits to dispensaries for routine immunization. Of the 1040 samples, 544 (52%) were positive for Streptococcus pneumoniae. The percentage of pneumococcal strains with reduced susceptibility to penicillin (PRSP) was 21%. Several risk factors for pneumococcal carriage were identified. These included the Province that the child lived in, the ethnic group, age, and having a sibling less than 6 years of age. Risk factors for carriage of PRSP carriage were similar but also included additional risk factors such as attendance at day care and a history of antibiotic treatment. The eight most frequent serotypes were 6B, 19F, 14, 23F, 6A, 19A, 11A, and 16F. These serotypes accounted for 60% of all strains detected. The most frequent serotypes of PRSP were 14, 9 V, 19F, 23F, and 6B. They were more often identified in european children and 80% were vaccine serotypes. However, overall 250/544 (46%) of all pneumococcal isolates were those included in the 7 serotype vaccine.
Full- and part-time work: gender and welfare-type differences in European working conditions, job satisfaction, health status, and psychosocial issues.

OBJECTIVES The aim of this study was to analyze the differences between full- and part-time employment (FTE and PTE) in terms of working conditions, on the one hand, and job satisfaction, health status, and work-related psychosocial problems according to gender and welfare state regime, on the other hand, and to analyze the role of working conditions in the association between PTE and FTE. METHODS This cross-sectional study was based on a sample of 7921 men and 8220 women from the European Working Conditions Survey aged 16-64 years, who were employed part-time (5-19 or 20-30 hours per week) or full-time (31-40 hours/week). Multiple logistic regression models were fitted separately for each gender and welfare state regime. RESULTS PTE is associated with poorer working conditions than FTE for all national welfare types. Among women, only those in southern European countries experienced low job satisfaction [odds ratio after adjustment (OR adj) for sociodemographic variables, OR adj1.73, and 1.66, for those working 20-30 and 5-19 hours/week, respectively; reference group: FTE workers], but this association disappeared after further adjustment for working conditions. Low job satisfaction and poorer health status was more common among PTE men from continental (low job satisfaction, OR adj1.80 and 3.61, for 20-30 and 5-19 working hours/week, respectively), and southern European (OR adj, 2.98, for 5-19 working hours/week) countries. PTE tended to be associated with fewer psychosocial problems among women, but with more psychosocial problems among men in continental Europe and those those engaged in "mini-jobs" in southern European welfare regimes. CONCLUSIONS The association between FTE and PTE and job satisfaction, health status, and psychosocial problems is partly driven by working conditions and differs between gender and welfare regime. This highlights the importance of promoting effective measures to ensure equal treatment between FTE and PTE workers and the role of the social norms that form part of these different welfare states regimes.
Mapping of DNA instability at the fragile X to a trinucleotide repeat sequence p(CCG)n

The sequence of a Pst I restriction fragment was determined that demonstrate instability in fragile X syndrome pedigrees. The region of instability was localized to a trinucleotide repeat p(CCG)n. The sequence flanking this repeat were identical in normal and affected individuals. The breakpoints in two somatic cell hybrids constructed to break at the fragile site also mapped to this repeat sequence. The repeat exhibits instability both when cloned in a nonhomologous host and after amplification by the polymerase chain reaction. These results suggest variation in the trinucleotide repeat copy number as the molecular basis for the instability and possibly the fragile site. This would account for the observed properties of this region in vivo and in vitro.
Applying cathodically polarised substrata to the restoration of a high value coral

Larval settlement of the high value red coral, Corallium rubrum, was studied on three different CaCO3 substrata, viz. lithogenic (marble), electro-accreted calcium carbonate in the presence and in the absence of cathodic polarisation. The last two substrata consisted of stainless steel plates galvanically coupled with Zn anodes. The electrochemical characterization of the settlement device was studied in order to investigate correlations between cathodic parameters (polarisation potential, current density, calcareous deposit composition) and larval settlement. The results obtained in the natural habitat (at 35 m depth) showed that settlement was five times lower on the electro-accreted aragonite in the presence of low cathodic current densities (i ≤ 1 μA cm−2) compared to both marble tiles and electro-accreted aragonite in the absence of polarisation. These last two substrata showed similar settlement values. The implications of these findings on restoration strategies for C. rubrum are discussed.
Two‐dimensional electrophoresis protein profile of the phytopathogenic fungus Botrytis cinerea

Botrytis cinerea is a phytopathogenic fungi causing disease in a number of important crops. It is considered a very complex species in which different populations seem to be adapted to different hosts. In order to characterize fungal virulence factors, a proteomic research was started. A protocol for protein extraction from mycelium tissue, with protein separation by 2‐DE and MS analysis, was optimised as a first approach to defining the B. cinerea proteome. Around 400 spots were detected in 2‐DE CBB‐stained gels, covering the 5.4–7.7 pH and 14–85 kDa ranges. The averages of analytical and biological coefficients of variance for 64 independent spots were 16.1% and 37.5%, respectively. Twenty‐two protein spots were identified by MALDI‐TOF or ESI IT MS/MS, with some of them corresponding to forms of malate dehydrogenase and glyceraldehyde‐3‐phosphate dehydrogenase. Two more spots matched a cyclophilin and a protein with an unknown function.
Does offshoring of materials and business services affect employment? Evidence from a small open economy

The fear of massive job losses has prompted a fast-growing literature on offshoring and its impact on employment in advanced economies. This article examines the situation for Belgium. It improves the offshoring intensity measure by computing a volume measure of the share of imported intermediates in output, and it is among the first to address both materials and business services offshoring to high wage and low wage countries. Estimations of static and dynamic industry-level labour demand equations augmented by offshoring intensities do not reveal a significant impact of either materials or business services offshoring on total employment for Belgium between 1995 and 2003. This result holds for both the manufacturing sector and the service sector and it proves robust to splitting the manufacturing sector into high technology and low technology industries.
Long-Term Efficacy of Dexamethasone-Cyclophosphamide Pulse Therapy in Pemphigus

Background: Corticosteroids are used as a daily oral therapy or in a pulse form with or without various adjuvant drugs for the treatment of pemphigus. Our long-term experience with the use of dexamethasone-cyclophosphamide pulse therapy as a first-line treatment modality for pemphigus is presented. Methods: A retrospective analysis of records of pemphigus patients treated by dexamethasone-cyclophosphamide therapy was carried out. The treatment regimen consisted of the monthly administration of intravenous dexamethasone (136 mg) for 3 consecutive days with addition of intravenous cyclophosphamide (500 mg) on the second day. Oral cyclophosphamide (50 mg) daily and oral corticosteroids (low tapering doses) were given in the intervals between the pulses, till partial remission was achieved. Pulse therapy was then continued for another 6 months followed by daily oral cyclophosphamide (50 mg) for 1 year, which produced a complete remission. Results: A total of 36 patients, 32 with pemphigus vulgaris and 4 with pemphigus foliaceus, were treated with this regimen. Two to 8 pulses were required to achieve a partial remission, while the total number of pulses given for complete remission ranged from 8 to 32. The duration of pulse therapy correlated with both the disease severity and the time to achieve remission. All patients are now in complete remission with a follow-up of 0.5–12 years. Four patterns of remission were observed, related to the severity of disease. The response to pulse therapy was faster in the milder form of disease. The severe form of disease required more pulses as well as higher doses of intervening oral corticosteroids. Conclusions: Dexamethasone-cyclophosphamide pulse therapy is an effective form of treatment in pemphigus and results in long-lasting remissions.
NAT1, NOS3, and TYMS genotypes and the risk of conotruncal cardiac defects.

BACKGROUND Although congenital heart defects (CHDs) are a common and serious group of birth defects, relatively little is known about the causes of these conditions, and there are no established prevention strategies. There is, however, evidence suggesting that the risk of CHDs in general, and conotruncal and related defects (CTRDs) in particular, may be associated with maternal folate status and genetic variants of folate-related genes. Although several folate-related genes have been studied as they relate to CHDs and CTRDs (e.g., MTHFR), others have not been adequately assessed. METHODS Case-parent triads were examined using log-linear analyses to assess the associations between CTRDs and both the genotype inherited by the case and the maternal genotype for the following variants: NAT1 1095C>A, NOS3 894G>T, and TYMS 1494del6. Subgroup analyses were also conducted among cases with classic conotruncal defects and cases with normally related great arteries. RESULTS The results provided little evidence that CTRD risk was associated with the genotype inherited by the case for any of the analyzed variants. However, our results suggest that CTRD risk may be associated with the maternal genotype for NOS3 894G>T (p = 0.024 in the subgroup with normally related great arteries) and TYMS 1494del6 (p = 0.048 in the subgroup with classic conotruncal defects). However, these results were not significant after correcting for multiple comparisons. CONCLUSION This study provides further evidence that CTRD risk may be related to variation within folate-pathway genes and suggests that these associations are, at least in part, mediated through the maternal genotype.
Functional performance and muscle strength phenotypes in men and women with Danon disease

Danon disease is a rare X‐linked myopathy that is characterized clinically by a triad of cardiomyopathy, skeletal myopathy, and cognitive impairment. The purpose of this investigation was to quantify functional performance, muscle weakness, and quadriceps activation in individuals with Danon disease as compared with healthy individuals. Four males (ages 10–34 years) and 4 females (ages 16–50 years), with the genetic markers of Danon disease, were compared with 8 healthy males (ages 22–34 years) and 8 healthy females (ages 23–41 years) and previously reported norms. Affected males and females had decreased functional performance, significant generalized muscle weakness, and decreased quadriceps strength and activation when compared with healthy individuals. Affected males had larger deficits in function, strength, and activation when compared with affected females. The results indicate that, although the presentation of Danon disease is variable and is typically only described in males, muscle weakness patterns exist in both affected males and females. Muscle Nerve 42: 908–914, 2010
Frequency response of fiber-optic multilayer hydrophones: experimental investigation and finite element simulation

The frequency response of a fiber-optic hydrophone that uses a dielectric multilayer system as the sensing element for ultrasound detection is investigated. A primary interferometric calibration technique is applied to determine by experiment the frequency-dependent pressure-voltage transfer function up to 45 MHz. The interaction between an incident pressure wave and the fiber end is analyzed by finite element methods. The simulation yields the response of the sensor to a short Gaussian impulse in the time domain from which the transfer function is calculated. The results of the model simulations allowed the transfer function obtained to be interpreted as the result of the superposition of longitudinal, edge diffraction and lateral waves with a resonant vibration mode of the fiber body representing an elastic rod.
A wavelet-collocation approach for computational electromagnetics ⁄

AbstractAwavelet-collocationscheme,constructedfromthediscretesingularconvolution(DSC)is introduced for computational electromagnetics. The basic philosophy behind the DSCalgorithmisstudied. Fourtestproblems,includingwaveguideanalysisinbothregularandirregulardomains,electromagneticwavescattering,electrostaticﬂeldestimationviapoten-tialfunctions, andelectromagneticwavepropagationinthreespatialdimensions, areem-ployedtoillustratetheusefulness,testtheaccuracyandexplorethelimitationofthewaveletalgorithm. Computationalaccuracyofthewaveletalgorithmisshowntobecontrollableandiscomparedwithastandardapproach. Numericalexperimentsindicatethattheproposedwaveletalgorithmisapromisingapproachforsolvingproblemsinelectromagnetics. Keywords:Maxwell’sequations,waveguide,wavescattering,potentialfunction,wavepropaga-tion,wavelet-collocation,discretesingularconvolution. 1 Introduction Recently,computationalelectromagnetics(CEM)hasemergedasadistinctscientiﬂcdisciplineforthestudyandunderstandingofawidevarietyofelectricalandelectronicengineeringproblems[1,2,3,4,5,6,7,8]. Asanaturalextensiontotheanalyticalapproach,theCEMisbasedonnumericallysolvingthegoverningequationseitherinthepartialdiﬁerentialformorintheintegralequationform. ThecomplexitiesofphysicsandoftheﬂeldgeometryarenolongerthelimitingfactorstoCEMastheyaretotheanalyticalapproach. Withtheadventofhigh-performancedigitalcomputers,CEMisemergingasapowerfulapproachforsolvingpracticalproblemsinelectromagnetics[1,2]. Asacomputationaldiscipline,thesuccessoftheCEMisvitallydependentonthevirtuesofcomputationalalgorithms,suchasnumericalaccuracy,stabilityande–ciency.TheseinturndependongridmethodsandnumericalschemesforthesolutionoftheMaxwell’sequations.Typically,gridmethodsusedinCEMareeitherlocal,suchasﬂnitediﬁerence(FD)methods[2],orglobal,suchasFourierpseudospectralmethods[3]. Globalmethodsarehighlyaccuratebutarecumbersometoimplementincomplexgeometriesandnon-conventionalboundarycondi-tions.Incontrast,localmethodsareeasytoimplementforcomplexgeometriesanddiscontinuousboundaryconditions. However,theaccuracyoflocalmethodsisrelativelylow[4]. Thereexists
Study of the Immunological Status of Patients with Pulmonary Tuberculosis

Most patients with pulmonary tuberculosis have impaired T‐lymphocyte function as measured by dinitrochlorobenzene (DNCB) sensitization and response to tetanus toxoid. The humoral immune response as gauged by the ability to respond to typhoid vaccine was not affected. Tuberculous patients had higher immunoglobulin levels than normal controls. The relative proportions of T lymphocytes in patients were lower than in controls while those of B lymphocytes were normal. By these criteria, rifampin treatment did not seem to cause immunosuppression.
The distinct clinical features of giant cell tumor of bone in pagetic and non-pagetic patients are associated with genetic, biochemical and histological differences

Giant Cell Tumor of Bone (GCT) is a tumor characterized by neoplastic mesenchymal stromal cells and a high number of osteoclast-like multinucleated giant cells. Rarely, GCT could arise in bones affected by Paget's disease of bone (GCT/PDB). Although it is already known that GCT/PDB and GCT show a different clinical profile regarding the age-onset and skeletal localization, our deep clinical comparison between the two GCT/PDB and GCT cohorts, permitted us to identify additional differences (e.g. focality, ALP serum levels, the 5-year survival rate and the familial recurrence), strongly suggesting a different molecular basis. Accordingly, driver somatic mutations in H3F3A and IDH2 were described in GCT patients, while we recently identified a germline mutation in ZNF687 as the genetic defect of GCT/PDB patients. Here, we detected H3F3A mutations in our GCT cohort, confirming its molecular screening as the elected diagnostic tool, and then we excluded the two-hit in H3F3A and IDH2 as the trigger event for the GCT/PDB development. Importantly, we also identified an alternative biochemical profile with GCT/PDB not exhibiting the up-regulation of the GCT marker FGFR2IIIc. Finally, our histological analysis also showed a different appearance of the two forms of the tumor, with GCT/PDB showing a higher number of osteoclast-like giant cells (twice), with an abnormal number of nuclei per cell, corroborating its different behaviour in terms of neoplastic properties. We demonstrated that the distinct clinical features of pagetic and conventional GCT are associated with different genetic background, resulting in a specific biochemical and histological behaviour of the tumour.