Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficient Mobility Support by Indirect Mapping in Networks With Locator/Identifier Separation

In networks with locator/identifier separation, it is of critical importance to design an elegant mapping service to map identifiers onto locators. While there are many mapping services in the literature, how to support efficient host mobility is still an open issue. In this paper, we first borrow the idea of indirection from proxy mobile IPv6 and incorporate it into the design of a mapping service. In particular, we divide the network into many rendezvous domains (RDs) and assign a rendezvous point (RP) to a mobile node (MN) when it moves into an RD. In addition, the mapping registered into a mapping system for the MN is the mapping from the MN's identifier onto the RP's locator. When other nodes send packets to the MN, these packets are first sent to the MN's RP, which then sends packets to the attaching egress tunnel router. This way, the identifier-to-locator mapping for the MN remains unchanged as long as it roams within the same RD, thus supporting efficient host mobility. We then propose a method to build large RDs and handover processes to deal with host mobility. We also present numerical results to demonstrate the performance of the proposed approaches.
Intracellular Localization of the Pseudorabies Virus Large Tegument Protein pUL36

ABSTRACT Homologs of the essential large tegument protein pUL36 of herpes simplex virus 1 are conserved throughout the Herpesviridae, complex with pUL37, and form part of the capsid-associated “inner” tegument. pUL36 is crucial for transport of the incoming capsid to and docking at the nuclear pore early after infection as well as for virion maturation in the cytoplasm. Its extreme C terminus is essential for pUL36 function interacting with pUL25 on nucleocapsids to start tegumentation (K. Coller, J. Lee, A. Ueda, and G. Smith, J. Virol. 81:11790-11797, 2007). However, controversy exists about the cellular compartment in which pUL36 is added to the nascent virus particle. We generated monospecific rabbit antisera against four different regions spanning most of pUL36 of the alphaherpesvirus pseudorabies virus (PrV). By immunofluorescence and immunoelectron microscopy, we then analyzed the intracellular location of pUL36 after transient expression and during PrV infection. While reactivities of all four sera were comparable, none of them showed specific intranuclear staining during PrV infection. In immunoelectron microscopy, neither of the sera stained primary enveloped virions in the perinuclear cleft, whereas extracellular mature virus particles were extensively labeled. However, transient expression of pUL36 alone resulted in partial localization to the nucleus, presumably mediated by nuclear localization signals (NLS) whose functionality was demonstrated by fusion of the putative NLS to green fluorescent protein (GFP) and GFP-tagged pUL25. Since PrV pUL36 can enter the nucleus when expressed in isolation, the NLS may be masked during infection. Thus, our studies show that during PrV infection pUL36 is not detectable in the nucleus or on primary enveloped virions, correlating with the notion that the tegument of mature virus particles, including pUL36, is acquired in the cytosol.
A Cross-cultural Sociopragmatic Study - Apology Speech Act Realization Patterns in Indonesian, Sundanese, and Japanese

: In everyday life, when a person has performed an action of utterance which has offended another person, and for which he can be held responsible, the person needs to apologize. However, in the cross-cultural context, different rules and customs may apply according to its language and cultural background. This study examined the differences and similarities of apology speech acts and strategies used in different cross-cultural contexts, i.e., in Indonesian, Sundanese, and Japanese. The data on this research were collected using Discourse Completion Test (DCT), which investigated four apology situations focused on the relations with the interlocutors. The subjects of this study were 60 Japanese native speakers, 60 Indonesian native speakers, and 54 Sundanese native speakers. The collected data were then classified using Cross-Cultural Speech Act Realization Pattern (CCSARP) coding scheme. The study findings revealed that Indonesian, Sundanese, and Japanese native speakers used four similar strategies overall, but used different main strategies depending on the relation with the interlocutor. Moreover, Indonesian and Japanese native speakers tend to express apology in the highest frequency, whereas Sundanese native speakers tend to express their responsibility in the highest frequency. Furthermore, the difference of apology speech act also showed in utterance level which indicates the characteristics of each language. This study is expected to give a reference in speech act study, and help understanding apology in cross-cultural context.
Distribution of melatonin receptors in murine pancreatic islets

Abstract: Melatonin has multiple receptor‐dependent and receptor‐independent functions. At the cell membrane, melatonin interacts with its receptors MT1 and MT2, which are expressed in numerous tissues. Genome‐wide association studies have recently shown that the MTNR1B/MT2 receptor may be involved in the pathogenesis of type 2 diabetes mellitus. In line with these findings, expression of melatonin receptors has been shown in mouse, rat, and human pancreatic islets. MT1 and MT2 are G‐protein‐coupled receptors and are proposed to exert inhibitory effects on insulin secretion. Here, we show by immunocytochemistry that these membrane melatonin receptors have distinct locations in the mouse islet. MT1 is expressed in α‐cells while MT2 is located to the β‐cells. These findings help to unravel the complex machinery underlying melatonin’s role in the regulation of islet function.
Microscopic Polyangiitis

Microscopic polyangiitis is a systemic vasculitis affecting smal-l and medium-sized vessels and is characteristically associated with a focal and segmental necrotizing glomerulonephritis. It may present as a pulmonary-renal syndrome with rapidly progressive glomerulonephritis and alveolar hemorrhage, but the pattern of disease will vary according to the organ systems involved. Granulomatous disease of the upper or lower respiratory tract is not a feature, and its presence suggests the diagnosis of Wegener's granulomatosis. The etiology of the condition is unclear, but most patients have antineutrophil cytoplasm antibodies (ANCA) with specificity for either myeloperoxidase (MPO) or proteinase 3 (PR3), and there is increasing evidence that these may be pathogenic. Current treatment includes an induction phase using cyclophosphamide and steroids to attain remission, followed by a maintenance phase in which the levels of immunosuppression are gradually reduced. Azathioprine may be substituted for cyclophosphamide at 3 months. Adjunctive plasma exchange or intravenous methylprednisolone is used in the management of either or both severe renal disease and alveolar hemorrhage, and new evidence suggests that plasma exchange is more effective in recovery of renal function. Overall, 1-year survival in systemic vasculitis is around 85%, and up to 50% of patients relapse, although relapse is less common in those with MPO-ANCA. Newer therapies are being explored in an attempt to increase the efficacy and reduce the toxicity of treatment.
Parameters predicting follicular carcinoma in thyroid nodules with indeterminate cytology.

AIM To determine the parameters supporting the malignancy by comparing demographic features of patients and nodule features in malign and benign nodules according to the pathology results after thyroidectomy in patients with the suspicious fine needle aspiration biopsy (FNAB) results for follicular neoplasia. MATERIAL AND METHOD Thyroidectomy performed 152 cases with the suspicion of follicular carcinoma owing to the FNAB results were included in the study. Age, radiation exposure history, and serum TSH levels of patients were recorded as well as the ultrasound findings of nodules as nodule count, diameter, internal structure, echogenicity, border features, presence of peripheral halo, and presence of internal micro calcifications. Scintigram findings of nodules were also recorded. RESULTS The mean age of the patients was 48,14 years (range: 20-71 years). Twenty five (16,5%) of the patients were male while 127 (83,5%) were female. Among patients with higher than normal TSH levels, malignancy was more common compared with the patients with normal or lower TSH levels. Presence of intranodular calcifications [Odd's Ratio: 3,1; 95 % Confidence Interval: 1,3-7,4], increase in intranodular vascularization [Odd's Ratio: 14,7; 95% Confidence Interval: 1,4-147,7], absence of halo sign [Odd's Ratio: 0,1; 95% Confidence Interval: 0,04-0,8], and ill-defined margins [Odd's Ratio: 0,1; 95% Confidence Interval: 0,49-0,3] were statistically significantly more common in malignant cases. CONCLUSION The ability of clinical features, and sonographic parameters to predict malignancy in indeterminate thyroid nodules should be kept in mind since ultrasound is a simple, easy and inexpensive tool in the diagnosis of thyroid nodules.
Oil Prices and Monetary Policy in Emerging Markets: Structural Shifts in Causal Linkages

ABSTRACT This study tests the causal relationships between oil prices and monetary policy for the emerging markets (Brazil, India, Indonesia, South Africa, and Turkey). In particular, we explore the role of exchange rates, inflation, and interest rates. First, we utilize the commonly used Toda–Yamamoto causality framework and later augment the model to account for structural shifts—including gradual/smooth shifts. The empirical findings show that (i) accounting for gradual structural shifts matter for the causal linkages between oil prices and the monetary policy variables and (ii) employing a bivariate or multivariate frameworks is not important (with few exceptions) as much as controlling for structural breaks in these causal linkages.
The cortical response to a noxious procedure changes over time in preterm infants

Abstract The aim of the study was to investigate whether cortical response to a repeated noxious procedure may change over time in preterm infants. Possible reasons for change are: (1) advancing maturation of central nervous system; and (2) increasing experience with noxious procedures during hospital stay. Sixteen preterm infants were recruited, with a postmenstrual age (PMA) ranging between 29 and 36 weeks. Newborns were assessed during a heel-prick procedure, once a week for at least 3 consecutive times. Multichannel near-infrared spectroscopy was used to detect cortical activation, by measuring increase in cortical oxy-haemoglobin (HbO2). Parietal, temporal, and posterior frontal areas were monitored bilaterally. By regression analysis, we studied the effect of (1) increasing PMA and (2) increasing number of heel pricks, on the magnitude of cortical activation. We observed a bilateral nociceptive event-related activation of the posterior frontal cortex, mainly contralateral to the side pricked. Additionally, we found a significant positive effect of PMA, as HbO2 progressively increased in the posterior frontal cortex (P < 0.001), bilaterally, over time. Conversely, the degree of cortical activation decreased as the number of noxious events increased (P < 0.002). We conclude the following: (1) Preterm newborns showed a significant activation of the posterior frontal cortex in association with noxious stimuli; (2) Cortical activation was progressively greater with increasing PMA; (3) There was an inverse relationship between cortical activation and the number of heel pricks. We speculate that such findings may be due to both endogenous cortical maturation and experience-dependent neuroplasticity of the developing brain (eg, synaptogenesis, synaptic pruning).
Unicellular, aerobic nitrogen-fixing cyanobacteria of the genus Cyanothece

Two marine, unicellular aerobic nitrogen-fixing cyanobacteria, Cyanothece strain BH63 and Cyanothece strain BH68, were isolated from the intertidal sands of the Texas Gulf coast in enrichment conditions designed to favor rapid growth. By cell morphology, ultrastructure, a GC content of 40%, and aerobic nitrogen fixation ability, these strains were assigned to the genus Cyanothece. These strains can use molecular nitrogen as the sole nitrogen source and are capable of photoheterotrophic growth in the presence of 3-(3,4-dichlorophenyl)-1,1-dimethylurea and glycerol. The strains demonstrated a doubling time of 10 to 14 h in the presence of nitrate and 16 to 20 h under nitrogen-fixing conditions. Rapid growth of nitrogen-fixing cultures can be obtained in continuous light even when the cultures are continuously shaken or bubbled with air. Under 12-h alternating light and dark cycles, the aerobic nitrogenase activity was confined to the dark phase. The typical rates of aerobic nitrogenase activity in Cyanothece strains BH63 and BH68 were 1,140 and 1,097 nmol of C2H2 reduced per mg (dry weight) per h, respectively, and nitrogenase activity was stimulated twofold by light. Ultrastructural observations revealed that numerous inclusion granules formed between the photosynthetic membranes in cells grown under nitrogen-fixing conditions. These Cyanothece strains posses many characteristics that make them particularly attractive for a detailed analysis of the interaction of nitrogen fixation and photosynthesis in an aerobic diazotroph.
The Ratio of Metastatic/Resected Lymph Nodes is an Independent Prognostic Factor in Patients With Node-positive Pancreatic Head Cancer

Objectives: The aim of this study was to evaluate the prognostic value of nodal involvement in resected adenocarcinoma of the pancreatic head. Methods: For the period between 1980 and 2002, 96 patients underwent pancreaticoduodenectomy for pancreatic cancer. Lymph nodes were numbered and classified into groups according to the Japan Pancreatic Society rules. Metastatic lymph nodes were identified based on hematoxylin and eosin staining. Results: Sixty-four (66.7%) patients had positive lymph nodes. The median number of metastatic nodes was 2 (95% confidence interval [CI], 1.0-3.0) and the median ratio of metastatic/resected nodes was 9.7% (95% CI, 7.1%-14.4%). The median survival was 14.2 months (95% CI, 10.7-17.7) and was significantly higher for node-negative than node-positive patients (27.9; 95% CI, 20.9-34.9 vs. 10.6; 95% CI, 8.7-12.5; P < 0.001). The Cox proportional hazards model, including all patients, demonstrated that nodal involvement (hazard ratio [HR], 1.461; 95% CI, 1.177-12.024), moderate or poor tumor differentiation (HR, 2.330; 95% CI, 1.181-6.949), and positive resection margins (HR, 3.838; 95% CI, 1.390-10.597) were independent negative prognostic factors. If the analysis was limited to node-positive patients, lymph node ratio of more than 20% (HR, 1.364; 95% CI, 1.116-2.599), moderate or poor tumor differentiation (HR, 3.393; 95% CI, 1.041-11.061), and positive resection margins (HR, 9.400; 95% CI, 2.235-39.536) significantly correlated with a poorer survival. Conclusions: Lymph node ratio seems to be a new promising prognostic factor in patients with respectable node-positive pancreatic head cancer.
Neuroendocrine control of a sexually dimorphic behavior by a few neurons of the pars intercerebralis in Drosophila

In Drosophila, locomotor activity is sexually dimorphic and the brain area controlling this dimorphism has been mapped. The neurons of the pars intercerebralis (PI) have been suggested to participate in such differences between males and females. However, the precise physical nature of the dimorphism, the identity of the PI neurons involved, and the nature of the neuronal signal coding the dimorphism remain unknown. In this study, we used a video-tracking paradigm to characterize further the pattern of locomotor activity in Drosophila. We show that the number of activity/inactivity periods (start/stop bouts) is also sexually dimorphic, and that it can be genetically feminized in males. Moreover, the transplantation of PI neurons from a female, or of feminized PI neurons from a donor male into a receiver wild-type male is sufficient to induce the feminization of locomotor behavior, confirming that this tiny cluster of ≈10 neurons is directly responsible for the sexual dimorphism in locomotor activity. Finally, feeding males with fluvastatin, a juvenile hormone (JH) inhibitor, also led to start/stop feminization, and this effect is reversible by the simultaneous application of methoprene, a JH analog, suggesting the existence of a neuroendocrine control, by JH, of such behavioral dimorphism.
Between social capital and formal governance in farmer cooperatives: Evidence from China

Although social capital has been regarded as valuable for organizations, some scholars have noticed that the effect of social capital on economic performance is nonlinear and depends on formal governance. This article examines the role of social capital and the interaction of social capital and formal governance in influencing the economic performance of farmer cooperatives. An empirical exploratory study is conducted based on a data set of 147 farmer cooperatives in China, and an ordinary least squares regression model is used to estimate the results. The results show that the stock of social capital can enhance the economic performance of farmer cooperatives and that social capital has a larger impact when there is stronger formal governance with regard to income distribution. Social capital and formal governance are therefore complementary. An improvement in some aspects of formal governance is favorable to the outcome of social capital. Cooperative practitioners need to consider the creation of both social capital and formal governance.
NS1643 enhances ionic currents in a G604S‐WT hERG co‐expression system associated with long QT syndrome 2

Loss of function mutations in the human ether‐a‐go‐go‐related gene (hERG) cause long QT syndrome type 2 (LQT2). Most LQT2 patients are heterozygous mutation carriers in which the mutant hERG exerts potent dominant‐negative effects. 1, 3‐bis‐(2‐hydroxy‐5‐trifluoromethyl‐phenyl)‐urea (NS1643) is known to enhance IKr in WT‐hERG. We investigated its actions following lipofectamine‐induced expression of both mutant G604S‐ and WT‐hERG in the heterologous HEK293 expression system. Cells transfected with pcDNA3‐G604S‐hERG did not lead to any expression of detectable currents whether before or following NS1643 challenge. Cells transfected with both pcDNA3‐WT‐hERG and pcDNA3‐G604S‐hERG showed reduced hERG currents compared to those transfected with pcDNA3‐G604S‐hERG consistent with the reduced trafficking and formation of modified heteromeric WT‐G604S channels reported on earlier occasions. Nevertheless, NS1643 then continued to produce concentration‐ and voltage‐dependent increases in hERG current amplitude. It did not affect the voltage dependence of activation, recovery from inactivation and deactivation. However, NS1643 (30 μmol/L) slowed steady state inactivation and shifted the steady state half maximal activation voltage (V1/2) of the inactivation curve by +10 mV, and significantly increased the time constants of inactivation. Our present experimental results suggest that NS1643 significantly increases ion current and attenuates its inactivation in cells co‐expressing G604S‐hERG and WT‐hERG. These findings raise the possibility that hERG channel activators offer potential treatment strategies for inherited LQT2.
CTX-M β-Lactamase–producing Klebsiella pneumoniae in Suburban New York City, New York, USA

CTX-M extended-spectrum β-lactamase (ESBL)–producing Klebsiella pneumoniae isolates are infrequently reported in the United States. In this study, we analyzed nonduplicate ESBL-producing K. pneumoniae and Escherichia coli clinical isolates collected during 2005–2012 at a tertiary care medical center in suburban New York City, USA, for the presence of blaCTX-M, blaSHV, blaTEM, and blaKPC genes. Despite a high prevalence of blaCTX-M genes in ESBL-producing E. coli since 2005, blaCTX-M genes were not detected in K. pneumoniae until 2009. The prevalence of CTX-M–producing K. pneumoniae increased significantly over time from 1.7% during 2005–2009 to 26.4% during 2010–2012 (p<0.0001). CTX-M-15 was the dominant CTX-M genotype. Pulsed-field gel electrophoresis and multilocus sequence typing revealed high genetic heterogeneities in CTX-M–producing K. pneumoniae isolates. This study demonstrates the recent emergence and polyclonal spread of multidrug resistant CTX-M–producing K. pneumoniae isolates among patients in a hospital setting in the United States.
Essays on macro-financial linkages

The main theme of this thesis are macro-financial linkages. I covered three different questions related to this topic. In the first chapter Gael Giraud and I develop a model for the Euro Area answering to many of the critiques of policy models before the Global Financial Crisis and with a focus on the interaction between the financial sector and the macroeconomy. The second and third chapter focus on behaviour of the financial sector in the aftermath of the Global Financial Crisis and its implications for the macroeconomy. Chapter 2 investigates the practice of forbearance towards stressed borrowers. The ultimately relevant question in this chapter is to what extend there is a feedback to the real economy due to this behaviour. Finally, the third chapter sheds light on an episode of manipulation in commodity markets. This alleged manipulation was apparently only possible due to the dominant market position banks took in the run up to the crisis and thereafter. Ultimately I quantify the effects of such behaviour and provide evidence of a structural change of the manipulated market during the period of alleged manipulation. The first chapter exploits a bank level dataset, whereas in chapter 2 and 3 I develop structural macroeconomic models. Especially the dynamical system model in the second chapter is an innovation. This class of models and more specifically a model of the size we develop has never been estimated and subsequently used for policy analysis.
Acetaminophen and acetylcysteine dose and duration: Past, present and future

Abstract Acetylcysteine has been utilized successfully in the treatment of acetaminophen overdose since the 1970s. Although prospective trials as to efficacy and safety of acetylcysteine were conducted, there were no randomized controlled trials. This commentary addresses the reasons for this, and the background to choice of dose of acetylcysteine utilized in the oral and IV dosing regimens. Nomograms to predict possible hepatotoxicity based upon time of ingestion of acetaminophen were developed from a relatively arbitrary definition of toxicity as an aspartate aminotransferase/alanine aminotransferase (ALT/AST) greater than 1000 IU/L. While these have proved generally useful, patients still continue to develop hepatic damage after acetaminophen overdose, particularly if they present late after ingestion. The optimum management of these patients remains unclear, and one area of uncertainty is the dose and duration of acetylcysteine in various circumstances. This article discusses the issues that need to be elucidated to better target changes in acetylcysteine dose. The potential for measurements of other markers to improve treatment selection is the subject of further research.