Miracle-dz/UniFAR-FTUs huggingface dataset:
The clinical characteristics and investigations planned in patients with stable angina presenting to cardiologists in Europe: from the Euro Heart Survey of Stable Angina

AIMS: The Euro Heart Survey of Stable Angina set out to prospectively study the presentation and management of patients with stable angina as first seen by a cardiologist in Europe, with particular reference to adherence to existing guidelines and regional variability in patient presentation and initial assessment. METHODS AND RESULTS: Consecutive outpatients with a clinical diagnosis by a cardiologist of stable angina were enrolled in the study and 3779 patients were included in the analysis. The average age was 61 years and 58% were male. The majority of patients (88%) had mild to moderate angina, CCS class I or II. Despite a high prevalence of recognized risk factors, 27% did not have cholesterol and 33% did not have glucose measured within 4 weeks of assessment. The resting ECG was abnormal in 41% of patients. An exercise ECG was performed or planned as part of initial investigation in 76% of patients and 18% had a stress imaging test such as perfusion scanning or stress echo. A coronary angiogram was performed or planned in 41%, and 64% had an echo. The time from assessment to investigation varied widely, particularly for angiography. One in 10 patients had neither any form of stress test nor angiography, with marked regional variation. Availability of invasive facilities increased the likelihood of both non-invasive and invasive investigations. Those with more severe symptoms or longer duration of symptoms or a positive non-invasive test were more likely to have angiography. In multivariable analysis, a positive stress test was the strongest predictor of the use of angiography, associated with a six-fold increase in the likelihood of invasive investigation. However, gender and availability of facilities were also predictive. CONCLUSION: Considerable variation in features at presentation and use of investigations has been identified in the stable angina population in Europe. The evaluation of biochemical cardiovascular risk factors was suboptimal. Overall rates of non-invasive investigation for angina and the clinical appropriateness of factors predictive of the use of invasive investigation were broadly in line with guidelines. However, the influence of access to facilities, and marked international variation in rates and timing of investigation suggest that factors unrelated to clinical need are also influential in the management of patients with stable angina.
The Influence of Computer Experience and Screen Size on Use Performance and Perceptions of a Tablet-Based Chronic Illness Self-Management System for Older Adults

A usability study of a tablet-based chronic illness self-management system was conducted to evaluate the system’s usability and to examine the effects of screen size and computer experience on use performance and perceptions of the system. A two-factor, between-subjects design was implemented, in which 40 older adults aged from 55 to 88 years were equally assigned to two screen size groups and required to perform a set of self-management tasks. The results showed that screen size had no effect on either the use performance or perceptions of the system, and that computer experience had significant effects on the former but no effect on the latter. Older adults without computer experience tended to perceive the large tablet screen system as more useful. This study verified the usability of the tablet-based self-management system with older adults. Its findings suggest the need to determine an optimal screen size for consumer health information technologies, and highlight the importance of computer experience in usability studies. Future studies may address its limitations.
Some observations on Saudi medicinal plants of veterinary importance.

Current study was undertaken during summer 2010 in Saudi Arabia, with the aim to investigate the significance of medicinal plants and their use in the treatment of different ailments in livestock. The plants were collected, properly identified, and their folklore traditional uses were recorded. Ethno-veterinary information was collected through the show-and-tell/semi-structured method and personal interviews during field trips. The methodology was largely based on the Sustainable Livelihood Framework, which is based on the premise that livelihood is not about resource productivity but it was about people and their lives. The study revealed 24 plants species to be of ethno-veterinary importance in traditional Saudi Medicine. The major traditional uses were to treat livestock for ailments such as: gastrointestinal disorders, fever, cough, respiratory tract infection, and urinary tract diseases, promote lactation, wound healing, placenta removal, devorming, carminative, and to cure paralysis and flatulence. It was noticed that a few plants were used singly while the others were used in combination with other plants or edible items. It was interesting to notice that some plants species were selectively used to treat a specific disease while several other plants had multiple uses. The data was collected on the local uses; local recipe preparation, application and disease treated for each medicinally important plant species. The data collected and observations made are useful for future record. The study concluded that knowledge of traditional healers about various medicinal plants used for animals health was strongly influenced by information recorded in Traditional Saudi Medicine. The current study accomplished the gaps existing between Traditional Saudi Medicine and the proper use of medicinal plants in animal care. It also became obvious that there was a strong influence on the standardization of plant knowledge among rural populations in Saudi Arabia. However, distinct local use of plants also existed; indicating that plant knowledge specific to the local Badous is alive and practiced. The study recommends scientific validity and toxicity tests of the medicinal plants used in traditional Arab system of medicine. Interestingly, it was observed that a type of interaction existed among the local Bedouins using medicinal plants to treat their animals and the traditional healers and experts practicing Traditional Saudi Medicine in rural population of Saudi Arabia. However, the current study recommended scientific validity and toxicity tests to be conducted on the medicinal plants used in traditional Arab system of medicine.
Treatment Fidelity in Sex Offender Programming: Assessing Delivery across Community Providers

Abstract In an effort to focus on treatment fidelity in the sex offender field, this study evaluated the treatment delivery of ten clinicians who provided treatment to sex offenders under community supervision. Data collection and analysis involved a combination of qualitative and quantitative methods. Results revealed that treatment providers varied in their use of empirically-supported treatment techniques, their participation in the community containment approach, and their adherence to the treatment contract. These findings provide support for the continued study of treatment fidelity in the corrections literature. Implications and future directions are discussed.
Benefit-Risk of Immunomodulators in Multiple Sclerosis. Alemtuzumab and Next?

End of December 2013, alemtuzumab, a monoclonal antibody for multiple sclerosis (MS) with an immunomodulator action targeting CD52 receptors and inducing decrease counts of lymphocytes B and T was rejected by the Food and Drug Administration, as the registration dossier had not shown convincing evidence that the benefit of the drug would overreach its safety risks. The question is in fact more global as immunomodulators constitute the majority of the newly registered drugs and drugs in clinical development for MS. The knowledge accumulated by the time these drugs are registered does not suffice to ascertain their safety profile. This is preoccupying as these treatments are intended to be administered to young patients who need to be treated for decades. Cumulative risks over years with such treatments are at the moment unknown but are certainly non negligible. Despite significant benefits of immunomodulation in the treatment of MS, the solution for treatment of disorders with auto-immune origin is likely to come from targeting more specific factors to avoid long-term depression of the immune system. Research and development in this direction need to be actively encouraged.
Meta-analysis of correlations among usability measures

Understanding the relation between usability measures seems crucial to deepen our conception of usability and to select the right measures for usability studies. We present a meta-analysis of correlations among usability measures calculated from the raw data of 73 studies. Correlations are generally low: effectiveness measures (e.g., errors) and efficiency measures (e.g., time) have a correlation of . 247 ± . 059 (Pearson's product-moment correlation with 95% confidence interval), efficiency and satisfaction (e.g., preference) one of . 196 ± . 064, and effectiveness and satisfaction one of . 164 ± . 062. Changes in task complexity do not influence these correlations, but use of more complex measures attenuates them. Standard questionnaires for measuring satisfaction appear more reliable than homegrown ones. Measures of users' perceptions of phenomena are generally not correlated with objective measures of the phenomena. Implications for how to measure usability are drawn and common models of usability are criticized.
The Extent of Family Violence in Europe

This article reviews current victim studies on family violence in Europe and attempts to interpret the variation in the prevalence rates. Methodological shortcomings contribute in part to different rates across countries. The prevalence rates are also linked to preventive and causative factors. Three factors appear to explain the differing prevalence rates in European countries: deprived economic living conditions, traditional attitudes toward women and children, and a general tolerance of violent behavior in a given society. In addition, personal coping may influence whether a family member will act violently against another family member.
Mice deficient in H+-ATPase a4 subunit have severe hearing impairment associated with enlarged endolymphatic compartments within the inner ear

SUMMARY Mutations in the ATP6V0A4 gene lead to autosomal recessive distal renal tubular acidosis in patients, who often show sensorineural hearing impairment. A first Atp6v0a4 knockout mouse model that recapitulates the loss of H+-ATPase function seen in humans has been generated and recently reported (Norgett et al., 2012). Here, we present the first detailed analysis of the structure and function of the auditory system in Atp6v0a4−/− knockout mice. Measurements of the auditory brainstem response (ABR) showed significantly elevated thresholds in homozygous mutant mice, which indicate severe hearing impairment. Heterozygote thresholds were normal. Analysis of paint-filled inner ears and sections from E16.5 embryos revealed a marked expansion of cochlear and endolymphatic ducts in Atp6v0a4−/− mice. A regulatory link between Atp6v0a4, Foxi1 and Pds has been reported and we found that the endolymphatic sac of Atp6v0a4−/− mice expresses both Foxi1 and Pds, which suggests a downstream position of Atp6v0a4. These mutants also showed a lack of endocochlear potential, suggesting a functional defect of the stria vascularis on the lateral wall of the cochlear duct. However, the main K+ channels involved in the generation of endocochlear potential, Kcnj10 and Kcnq1, are strongly expressed in Atp6v0a4−/− mice. Our results lead to a better understanding of the role of this proton pump in hearing function.
Adolescent Violence Perpetration: Associations With Multiple Types of Adverse Childhood Experiences

OBJECTIVE: Adverse childhood experiences are associated with significant functional impairment and life lost in adolescence and adulthood. This study identified relationships between multiple types of adverse events and distinct categories of adolescent violence perpetration. METHODS: Data are from 136 549 students in the 6th, 9th, and 12th grades who responded to the 2007 Minnesota Student Survey, an anonymous, self-report survey examining youth health behaviors and perceptions, characteristics of primary socializing domains, and youth engagement. Linear and logistic regression models were used to determine if 6 types of adverse experiences including physical abuse, sexual abuse by family and/or other persons, witnessing abuse, and household dysfunction caused by family alcohol and/or drug use were significantly associated with risk of adolescent violence perpetration after adjustment for demographic covariates. An adverse-events score was entered into regression models to test for a dose-response relationship between the event score and violence outcomes. All analyses were stratified according to gender. RESULTS: More than 1 in 4 youth (28.9%) reported at least 1 adverse childhood experience. The most commonly reported adverse experience was alcohol abuse by a household family member that caused problems. Each type of adverse childhood experience was significantly associated with adolescent interpersonal violence perpetration (delinquency, bullying, physical fighting, dating violence, weapon-carrying on school property) and self-directed violence (self-mutilatory behavior, suicidal ideation, and suicide attempt). For each additional type of adverse event reported by youth, the risk of violence perpetration increased 35% to 144%. CONCLUSIONS: Multiple types of adverse childhood experiences should be considered as risk factors for a spectrum of violence-related outcomes during adolescence. Providers and advocates should be aware of the interrelatedness and cumulative impact of adverse-event types. Study findings support broadening the current discourse on types of adverse events when considering pathways from child maltreatment to adolescent perpetration of delinquent and violent outcomes.
Camp Jump Start: Effects of a Residential Summer Weight-Loss Camp for Older Children and Adolescents

OBJECTIVE: Residential weight-loss camps offer an opportunity for overweight and obese children to lose weight in a medically safe, supervised, supportive environment. The purpose of this report is to describe short-term outcomes in 76 children participating in a 4- or 8-week residential weight-loss camp for children and adolescents. PATIENTS AND METHODS: The camp program enrolled obese 10- to 18-year-old adolescents. The program consisted of structured and nonstructured physical activities and group educational sessions covering nutrition, physical fitness, and self-esteem. A diet plan of 3 balanced meals and 2 snacks per day was prepared under the supervision of a registered dietitian. Participants had height, weight, and blood pressure measured and performed a 1-mile run at maximum effort on an outdoor track. RESULTS: For all campers, statistically significant (P < .0001) reductions were observed for BMI, BMI z score, systolic blood pressure, body weight, and 1-mile run times. Compared with campers in the 4-week session, campers in the 8-week session had greater reductions in BMI, BMI z score, body weight, and systolic blood pressure. Multivariate analysis revealed that gender was a significant predictor for reduction in body weight, BMI, and BMI z score, all of which decreased more in boys than in girls. CONCLUSIONS: This report adds to the evidence that residential weight-loss camps are highly effective in improving measures of health and fitness among overweight and obese children and adolescents. Additional study is needed on the long-term effects of such camps in terms of weight maintenance, behavior change, and metabolic and health outcomes.
Racial/Ethnic Differences in Early-Life Risk Factors for Childhood Obesity

OBJECTIVE: By the preschool years, racial/ethnic disparities in obesity prevalence are already present. The objective of this study was to examine racial/ethnic differences in early-life risk factors for childhood obesity. METHODS: A total of 1343 white, 355 black, and 128 Hispanic mother–child pairs were studied in a prospective study. Mother's reported child's race/ethnicity. The main outcome measures were risk factors from the prenatal period through 4 years old that are known to be associated with child obesity. RESULTS: In multivariable models, compared with their white counterparts, black and Hispanic children exhibited a range of risk factors related to child obesity. In pregnancy, these included higher rates of maternal depression (odds ratio [OR]: 1.55 for black, 1.89 for Hispanic); in infancy more rapid weight gain (OR: 2.01 for black, 1.75 for Hispanic), more likely to introduce solid foods before 4 months of age (OR: 1.91 for black, 2.04 for Hispanic), and higher rates of maternal restrictive feeding practices (OR: 2.59 for black, 3.35 for Hispanic); and after 2 years old, more televisions in their bedrooms (OR: 7.65 for black, 7.99 for Hispanic), higher intake of sugar-sweetened beverages (OR: 4.11 for black, 2.48 for Hispanic), and higher intake of fast food (OR: 1.65 for black, 3.14 for Hispanic). Black and Hispanic children also had lower rates of exclusive breastfeeding and were less likely to sleep at least 12 hours/day in infancy. CONCLUSIONS: Racial/ethnic differences in risk factors for obesity exist prenatally and in early childhood. Racial/ethnic disparities in childhood obesity may be determined by factors that operate at the earliest stages of life.
deal.II—A general-purpose object-oriented finite element library

An overview of the software design and data abstraction decisions chosen for deal.II, a general purpose finite element library written in C++, is given. The library uses advanced object-oriented and data encapsulation techniques to break finite element implementations into smaller blocks that can be arranged to fit users requirements. Through this approach, deal.II supports a large number of different applications covering a wide range of scientific areas, programming methodologies, and application-specific algorithms, without imposing a rigid framework into which they have to fit. A judicious use of programming techniques allows us to avoid the computational costs frequently associated with abstract object-oriented class libraries. The paper presents a detailed description of the abstractions chosen for defining geometric information of meshes and the handling of degrees of freedom associated with finite element spaces, as well as of linear algebra, input/output capabilities and of interfaces to other software, such as visualization tools. Finally, some results obtained with applications built atop deal.II are shown to demonstrate the powerful capabilities of this toolbox.
Body Mass Index in Children and Their Parents: A Cross-Sectional Study in aStudy Population of Children from Southern Italy

The prevalence of overweight and obesity has increased over the last decades. Parental obesity plays an important role in determining childhood obesity. We aimed to evaluate the relationship between parental and offspring’ weight status in a population of children from South of Italy, as no data have ever been published from this area. We recruited 636 children (5.7 ± 1.5 years old) and their parents. Seventy-three (11.5%) and sixteen (2.5%) children were overweight and obese, respectively. Offspring weight status was significantly associated with parents’ weight status. The linear regression analysis showed that offspring BMI was more affected by paternal than by maternal BMI. Our data confirmed that parents’ weight status plays an important role on children’s BMI. Interestingly, in our study, parents’ height and weight were measured and not reported as in most of the previous papers, strengthening our conclusions. We suggest that intensive nutritional education and preventive programs should be performed in children with overweight / obese parents rather than in children with normal weight parent. Furthermore, nutritional education should be performed also for overweight parents to modify preventable risk factor for pediatric obesity.
Practice and Child Characteristics Associated With Influenza Vaccine Uptake in Young Children

OBJECTIVES: The objective of this study was to determine both practice and child characteristics and practice strategies associated with receipt of influenza vaccine in young children during the 2004–2005 influenza season, the first season for the universal influenza vaccination recommendation for all children who are aged 6 to 23 months. METHODS: Clinical and demographic data from randomly selected children who were aged 6 to 23 months were obtained by chart review from a community-based cohort study in 3 US counties. The proportion of children who were vaccinated by April 5, 2005, in each practice was obtained. For assessment of practice characteristics and strategies, sampled practices received a self-administered practice survey. Practice and child characteristics that predicted complete influenza vaccination were determined by using multinomial logistic regression. RESULTS: Forty-six (88%) of 52 sampled practices completed the survey and permitted chart reviews. Of 2384 children who were aged 6 to 23 months and were studied, 27% were completely vaccinated. The proportion of children who were completely vaccinated varied widely among practices (0%–71%). Most (87%) practices implemented ≥1 vaccination strategy. Complete influenza vaccination was associated with 3 practice characteristics: suburban location, lower patient volume, and vaccination strategies of evening/weekend vaccine clinics; with child characteristics of younger age, existing high-risk conditions, ≥6 well visits to the practice by 3 years of age, and any practice visit from October through January. CONCLUSIONS: Modifiable factors that were associated with increased influenza vaccination coverage included October to January practice visits and evening/weekend vaccine clinics.
Sensory neuropathy in a Border Collie puppy

The clinical, electrophysiological and pathological features of a purely sensory polyneuropathy in a Bordie Collie puppy are described. It was found to be ataxic, with a loss of proprioception and of pain sensation. Electrophysiological testing confirmed that the neuropathy was restricted to sensory function. Examination of nerve biopsy material revealed an axonopathy.