Miracle-dz/UniFAR-FTUs huggingface dataset:
Memory symptoms and memory performance of neurological patients.

The spontaneous memory symptoms of 100 brain-damaged patients suffering from a variety of conditions were elicited. The most frequent types of symptom related to memory for people's names, memory for recent events occurring a few days or weeks ago, memory for a spoken message and remembering to do something. The spontaneous symptoms from 50 non-brain-damaged patients were also elicited. There was a considerable degree of overlap between the type and incidence of symptoms in brain-damaged and control patients. Some symptoms (e.g. remembering people's names) were reported by a similar proportion of control as brain-damaged patients. A few symptoms (e.g. spatial disorientation, temporal disorientation) were reported by brain-damaged patients but not by any control patients. One symptom (remembering to do something) occurred more frequently in the control group of patients than in the brain-damaged group. The relationship between memory symptoms and memory performance was examined in a group of head-injured patients. A short questionnaire on memory symptoms was completed by each patient and by a close observer, and the head-injured subjects also performed tests of immediate and delayed recall. Although there was a highly significant correlation between degree of memory impairment as perceived by the patient and as perceived by an observer, there was generally a low correlation between subjective or observed memory impairment and scores on commonly used clinical memory tests.
Field ecology of sylvatic Rhodnius populations (Heteroptera, Triatominae): risk factors for palm tree infestation in western Ecuador

Most Rhodnius species (Triatominae) are primarily associated with palm trees. They maintain enzootic Trypanosoma cruzi transmission and are responsible for human infection (causing Chagas disease) through the Neotropics. Assessing whether individual palm traits (ecological and/or botanical) may increase the risk of palm infestation by triatomines is relevant in areas where bugs invade houses flying from peridomestic palms. We developed a novel fieldwork approach with that objective, and applied it to study infestation by sylvatic Rhodnius ecuadoriensis in 110 tagua palms (Phytelephas aequatorialis). Palm infestation (23% overall) was non‐randomly distributed in our sample. Palms located in anthropic landscapes were frequently infested (>27%, n = 92), whereas no bugs were collected from palms surveyed within forest remnants (n = 18; P = 0.01). The presence of abundant decaying vegetable matter (P = 0.001) and (to a lesser extent) epiphytic plants (P = 0.049) on palm crowns and stems increased the probability of infestation and was positively correlated with the apparent density of bug colonies (R2 = 0.68). A trend towards higher infestation rates in male palms (34%vs. 18%) could relate to female palm management (removal of infrutescences and vegetable debris) in areas where palm seeds are harvested. An outline of ‘risk palm ecotopes’ and environmental management‐based strategies for the control of peridomestic, palm tree‐living vector populations are proposed.
Draft Genome Sequence of Tannerella forsythia Type Strain ATCC 43037

ABSTRACT Tannerella forsythia is an oral pathogen implicated in the development of periodontitis. Here, we report the draft genome sequence of the Tannerella forsythia strain ATCC 43037. The previously available genome of this designation (NCBI reference sequence NC_016610.1) was discovered to be derived from a different strain, FDC 92A2 (= ATCC BAA-2717).
Disciplinary actions associated with the administration of local anesthetics against dentists and dental hygienists.

PURPOSE Research studies have demonstrated the need for and the ability of dental hygienists to provide local anesthetics for pain control and reduction of patient anxiety. Although two-thirds of state dental practice laws allow these services to be performed by dental hygienists, controversy exists between organized dentistry and dental hygiene regarding the administration of local anesthetics by dental hygienists. Some dentists believe the quality of care would be compromised and patient safety jeopardized because dental hygienists do not have adequate background knowledge to prevent complications and recognize emergencies caused by anesthetics. The purpose of this study was to collect quantitative data addressing safety when dental hygienists administer local anesthetics. RESULTS Eighteen responses were received, for a response rate of 69%. These data showed, over a 10-year period, no reports of disciplinary actions against dental hygienists for the administration of local anesthetics. CONCLUSION This study affirmed public safety, which should be helpful to states considering statutes to allow the administration of local anesthetics by dental hygienists. Results suggest that properly educated dental hygienists in the states surveyed have administered local anesthetics to patients without harm.
The Natural History of Epistaxis in Patients with Hereditary Hemorrhagic Telangiectasia in the Norwegian population: A Cross-sectional Study

Background Epistaxis is usually the first and most common symptom in hereditary hemorrhagic telangiectasia (HHT), which is known also as Rendu-Osler-Weber syndrome. The severity of HHT-associated epistaxis is highly variable and can affect the patient's quality of life. In the literature, the natural history of epistaxis in HHT patients has been described in a few countries but not from the Norwegian population. Objective This work focused on the natural history of epistaxis in the Norwegian population in a cross-sectional study. Material and Methods Ninety-eight patients with three or four Curaçao criteria were included. The severity of epistaxis was graded depending on epistaxis intensity, frequency, and the amount of blood transfusion during a period of 4 weeks. The epistaxis grades were studied in association with age, gender, gene mutation, age of onset, and whether the patient had or had not been treated for epistaxis during the last 2 years. Results Most of the HHT patients (90%) complained of mild-to-moderate epistaxis. Seventy-seven percent of the patients started epistaxis by or before the age of 20 years. The progression of HHT-associated epistaxis with age could not be proved statistically in this study. There was no statistically significant difference in the grades of epistaxis between HHT1 and HHT2 type, neither between female and male patients. Most of the patients started epistaxis by or before the age of 20 years. There was a significant difference in the grade of epistaxis between non-ENG, non-ALK1 carrier patients, and ENG or ALK1 carrier patients. Conclusion Compared with other populations, the grading of epistaxis in Norwegian patients with HHT gave generally similar results. A multicenter epidemiological study is required to get a larger study population. A common internationally accepted grading or classification system for epistaxis in HHT is highly recommended.
Action of Phenethyl Alcohol on the Synthesis of Macromolecules in Escherichia coli

Prevost, C. (University of California, Berkeley), and V. Moses. Action of phenethyl alcohol on the synthesis of macromolecules in Escherichia coli. J. Bacteriol. 91:1446–1452. 1966. —A kinetic study of the effects of various concentrations of phenethyl alcohol on the synthesis of ribonucleic acid (RNA), deoxyribonucleic acid (DNA), protein, and β-galactosidase in Escherichia coli has confirmed that RNA synthesis, rather than DNA synthesis, is first and most affected by phenethyl alcohol. The presence of inducer did not protect β-galactosidase synthesis from inhibition by phenethyl alcohol. Little preferential inhibition of β-galactosidase synthesis was observed; this is in contrast to the severe catabolite repression which results from partial inhibition of total protein synthesis caused by chloramphenicol or starvation for a required amino acid. We found no evidence that messenger RNA synthesis was inhibited to a greater extent than total RNA synthesis.
VALOR NUTRICIONAL DEL ENSILAJE DE RASTROJO DE PIÑA CON NIVELES CRECIENTES DE UREA

El objetivo de esta investigacion fue determinar el efecto de diferentes concentraciones de urea en las caracteristicas fermentativas y composicion nutricional de los ensilados de rastrojos de pina. El trabajo fue realizado utilizando la tecnica de microsilos en bolsas de 1kg. Se establecieron 4 niveles de urea (0, 0,5, 1, 1,5% p/p) con un unico nivel de inoculo bacterial (1 L/t) para todos los tratamientos. La inclusion de urea afecta de forma significativa, aumentando el pH de los tratamientos conforme aumenta el % de urea incluido, el nitrogeno amoniacal (NH3/NT) tambien se afecta pero sus niveles son bajos, lo que indica que hay una buena conservacion del nitrogeno en el silo, tambien se aumenta el contenido de PC, conforme se aumenta la inclusion de urea. La DIVMS se aumentada conforme se adiciona urea en los ensilados. El contenido de FDN y FDA y el contenido de energia de los tratamientos muestran diferencias significativas al compararlo con el tratamiento control, sin embargo no se encontraron diferencias en los tratamientos con inclusion de urea. El contenido de Carbohidratos no fibrosos (CNF) se reduce conforme se incrementa el nivel de urea incluido en las mezclas ensiladas. La inclusion de urea mejora el contenido de PC de los ensilados de rastrojos de pina permitiendo una mejor calidad del forraje y posibilidad de mejor aporte de nutrimentos para los animales rumiantes.
Expression of cytochrome P450 and MDR1 in patients with proctitis

Background. The aim of this study was to investigate the effect of inflammation on the gene expression of three cytochrome P450's (CYP) and P-glycoprotein (P-gp) in the rectal and colonic mucosa in patients with proctitis. Methods. Biopsies were obtained from inflamed and normal mucosa in association with routine sigmoidoscopy in patients with proctitis. The biopsies were snap-frozen in liquid nitrogen. Real time PCR (polymerase chain reaction) was used for quantitative analyses of mRNA specific for the CYP2E1, CYP3A4 and CYP3A5 gene and the MDR1 genes. Values were normalised based on gene expression of β-actin to enable comparisons between samples. Results. The gene expression of CYP2E1 and CYP3A4 was lower in mucosa with severe inflammation vs normal mucosa (p<0.05). For CYP3A5 and P-gp there was no significant difference when comparing normal and inflammatory changed mucosa. Conclusion. Our study suggests that at least for some of the CYP enzymes the expression decreases in response to the inflammatory process in the gastrointestinal tract.
A python-based software tool for power system analysis

This paper presents a power system analysis tool, called DOME, entirely based on Python scripting language as well as on public domain efficient C and Fortran libraries. The objects of the paper are twofold. First, the paper discusses the features that makes the Python language an adequate tool for research, massive numerical simulations and education. Then the paper describes the architecture of the developed software tool and provides a variety of examples to show the advanced features and the performance of the developed tool.
Characteristics and factors influencing treatment outcome of renal and perinephric abscess--a 5-year experience at a tertiary teaching hospital in Taiwan.

BACKGROUND AND PURPOSE Diagnosis of renal or perinephric abscess is still a challenge for physicians. This study investigated the effect of location and size of abscess and the time of diagnosis on treatment outcomes. METHODS This retrospective analysis enrolled 159 adult patients with renal, perinephric or mixed-type (renal plus perinephric) abscess hospitalized between June 2001 and June 2006. The outcomes of these patients were classified into "poor" and "success" in order to elucidate associated risk factors. 106 patients had clear information of the timing of diagnosis and were categorized into "early" and "delayed" diagnosis groups, depending on whether the diagnosis was made within or after 5 days of admission. RESULTS Compared with the early diagnosis group (n = 78), the delayed diagnosis group (n = 28) were older (59.9 +/- 15.9 vs 50.9 +/- 14.9 years, p=0.005) and had less costovertebral angle knocking pain (85.7% vs 51.3%, p=0.021), a higher rate of renal insufficiency (57.1% vs 15.4%, p<0.001) and hospital stay over 22 days (71.4% vs 24.4%, p<0.001). There was no significant difference between these two groups in clinical outcomes. Compared with renal abscess, both perinephric and mixed-type abscess had higher rates of larger abscess (>5 cm in diameter) [84.1% vs 25.6%, p<0.001; and 55.6% vs 25.6%, p=0.012, respectively] and lower rates of Escherichia coli infection (24.4% vs 59.4%, p<0.001; and 26.7% vs 59.4%, p=0.021, respectively). Among all culture-positive patients, the proportion of Klebsiella pneumoniae was 25.6%. Perinephric abscess had higher rates of percutaneous (56.3% vs 31.5%; p=0.005) and surgical drainage (29.2% vs 7.6%; p=0.001) than renal abscess. In multivariate analysis, age > or =65 years (p=0.006; odds ratio [OR], 7.008; 95% confidence interval [CI], 1.75-28.141), thrombocytopenia (p=0.002; OR [95% CI], 10.434 [2.344-46.444]), and abscess without drainage (p=0.001; OR [95% CI], 9.984 [2.640-37.758]) were independent factors for poor outcome (mortality or nephrectomy). CONCLUSION Old age, renal insufficiency and lack of costovertebral angle knocking pain may contribute to delayed diagnosis of renal or perinephric abscess, and prolonged hospital stay. The location and size of abscess did not affect clinical outcome in this study, which might be due to adequate abscess drainage. K. pneumoniae is not uncommon in renal or perinephric abscess in Taiwan.
The relation of sexual dysfunction to depression and anxiety in patients with Parkinson’s disease

Objective In this study, we aimed to find out whether sexual dysfunction in patients with Parkinson’s Disease (PD) was associated to PD-related disability and whether this relationship was modulated by depressive and anxiety symptoms. Methods Eighty-nine consecutive patients with idiopathic PD who attended to our movement disorders outpatient clinics between January 2011 and June 2014 were included in this study. The diagnosis of PD was confirmed by a movement disorders specialists in Neurology, according to UK Parkinson’s Disease Society Brain Bank Criteria. The Unified PD Rating Scale (UPDRS) motor was used to assess motor disability and Hoehn and Yahr stage (H&Y) was used to establish disease severity. Cognitive function was assessed by the Mini-Mental State Examination. Patients were also administered the Hamilton depression (HAMD) and anxiety (HAMA) rating scales. The sexual functions of the patients were rated by applying the Turkish version of the Arizona Sexual Experiences Scale (ASEX). Results The mean age at the time of the study visit was 67.74±9.05. Male/female ratio was 1.87. Mean UPDRS total was 29.06±13.96 and mean UPDRS motor was 17.62±9.07. Mean HAMD score was 13.92±10.86, 58.4% of the patients had minor or major depression; and mean HAMA score was 7.94±6.49, 56.2% of the patients had minor or major anxiety. The mean ASEX score was 18.54±7.27 out of a maximum of 30. ASEX total scores were correlated with age, H&Y stage and HAMA scores. Age and also age at onset were correlated with ASEX subdomains except sexual desire. There was no correlation between disease duration and ASEX subdomains. UPDRS motor score was correlated with erection/lubrication. HAMD was only correlated with orgasm satisfaction. HAMA score was correlated with stimulation and orgasm. Conclusion In patients with PD, there may be a common factor that modulates both depression, anxiety and sexual function. Further studies are needed to clarify the exact relationship.
Declining Loneliness Over Time

We examined changes in loneliness over time. Study 1 was a cross-temporal meta-analysis of 48 samples of American college students who completed the Revised UCLA Loneliness Scale (total N = 13,041). In Study 1, loneliness declined from 1978 to 2009 (d = −0.26). Study 2 used a representative sample of high school students from the Monitoring the Future project (total N = 385,153). In Study 2, loneliness declined from 1991 to 2012. Declines were similar among White students (d = −0.14), Black students (d = −0.17), male students (d = −0.11), and female students (d = −0.11). Different loneliness factors showed diverging trends. Subjective isolation declined (d = −0.20), whereas social network isolation increased (d = 0.06). We discuss the declines in loneliness within the context of other cultural changes, including changes to group membership and personality.
Drug Interaction Profile of Topiramate

Summary: In separate studies, potential pharmacokinetic interactions of topiramate (TPM) with phenytoin (PHT), carbamazepine (CBZ), and valproate (VPA) were evaluated. TPM was added to the baseline antiepileptic drug (AED) at a dosage of up to 800 mg/day, after which the baseline drug was discontinued, when possible. Addition of TPM produced no change in plasma levels of CBZ or CBZ epoxide (CBZ‐E). Modest increases in PHT plasma levels in six of 12 patients treated with PHT and TPM, and a small mean decrease in VPA levels noted in patients receiving VPA with TPM, were considered unlikely to require adjustments in the dosage of the concomitant AED when TPM is added or discontinued. When patients were changed from concomitant therapy with PHT or CBZ to TPM monotherapy, TPM clearance was reduced by approximately 50%, suggesting that an adjustment in TPM dose may be required when PHT or CBZ is discontinued from TPM‐treated patients. A slight increase in plasma TPM levels during monotherapy compared to concomitant therapy with VPA was considered clinically insignificant and not likely to require TPM dosage adjustment. In another study, oral clearance of digoxin was slightly increased when TPM was added, resulting in a small decrease in peak plasma levels of digoxin. In vitro studies conducted to date on a number of specific cy‐tochrome P450 isoforms show an effect of TPM only on the CYP2Cmeph isoform. The risk for clinically meaningful changes in plasma levels of traditional AEDs when TPM is added to or discontinued from concomitant regimens appears to be minimal. However, adjustments in TPM dosages are likely to be needed when potent enzyme inducers, such as PHT or CBZ, are added or discontinued. TPM has a relatively low propensity for clinically significant drug interactions, and its pharmacokinetic and drug interaction profiles represent a clear advance over those of the traditional AEDs.
Obstacles à la problématisation du temps dans une approche interdisciplinaire : l'explication de quelques phénomènes naturels par des élèves et de futurs enseignants tunisiens

La presente recherche s'interesse a l'apprentissage et a l'enseignement des sciences de la vie et de la terre aupres des eleves et de futurs enseignants. L'utilisation du temps geologique dans l'explication de quelques phenomenes naturels par les apprenants semble etre difficile. Nous engageons donc une reflexion epistemologique et didactique pour l'etude de ce concept dans une approche interdisciplinaire en se basant sur des elements d'histoire et de philosophie des sciences. Un diagnostic precis des difficultes d'apprentissages des apprenants, par le biais de maintes methodes de recherche, pourrait permettre de comprendre leurs problemes et de proposer des strategies afin de faciliter l'acquisition, non seulement du concept de temps, mais aussi d'autres concepts en sciences. Cette recherche a donc comme objectif l'identification des obstacles epistemologiques a la problematisation du temps. Pour atteindre notre objectif, la demarche methodologique suivie est pluriel. En premier temps, nous menons une exploration du terrain par une analyse de manuels et analyse des explications des eleves et des etudiants a propos des seismes, orogenese et crise biologique. Ces deux phases ont ete jumelees par une observation de classe et un entretien avec des etudiants. En deuxieme temps, nous menons une etude interdisciplinaire par des ateliers-debats avec les echantillons concernes afin de suivre la construction du temps dans une demarche de problematisation et l'interpretation de l'origine possible des obstacles a cette finalite. La recherche a permis de depasser le travail sur les conceptions a celui de la problematisation en identifiant un certain nombre de difficultes reliees a l'acquisition du temps geologique comme outil de mesure et de couplage de biologie-geologie. Les registres explicatifs dans lesquels travaillent les etudiants sont varies. Des registres favorisant la problematisation du temps tels que le mobilisme, l'evolutionnisme. D'autres registres dependent des obstacles identifies et ne favorisent pas la problematisation du concept en question. Les origines de ces obstacles sont plurielles. Un travail interdisciplinaire en se basant sur la construction de probleme comme outil methodologique didactique par le biais d'un debat mettant en jeu le role des questions de l'enseignant, l'histoire des sciences.etc. permettrait, non seulement de depasser les difficultes a la problematisation d'un concept, mais aussi d'ameliorer les methodes d'enseignement. Ainsi des axes de recherches devraient etre entrepris pour des approfondissements theoriques et pratiques.
The Role of Partner-Related Fascination in the Association Between Sexual Functioning and Relationship Satisfaction

Past studies have shown strong associations between sexual functioning and interpersonal factors. The aim of this pilot study was to investigate the moderating role of partner-related fascination—an important dimension of relationship quality—in the association between sexual functioning and relationship satisfaction in a community sample of Swiss men and women. A total of 70 individuals participated in an anonymous online survey. Variables related to sexual functioning, fascination and relationship satisfaction were subject to correlation, regression and moderation analyses.