Miracle-dz/UniFAR-FTUs huggingface dataset:
PURINE METABOLITES AND PYRIMIDINE BASES IN CEREBROSPINAL FLUID OF CHILDREN WITH SIMPLE FEBRILE SEIZURES

Adenosine monophosphate, inosine monophosphate, inosine, adenosine, guanosine, adenine, guanine, hypoxanthine, xanthine, uric acid and pyrimidine bases were determined in the CSF of 18 children after simple febrile seizures and in a control group. There was no statistically significant difference between the two groups for any of these metabolites. This suggests that simple febrile seizures neither significantly disturb the metabolism of nucleotides, nucleosides or bases, nor significantly deplete neuron adenosine triphosphate ATP levels.
A THEORY OF QUALITY MANAGEMENT UNDERLYING THE DEMING MANAGEMENT METHOD

In its current form, the Deming management method contains a prescriptive set of 14 points that serve as guidelines for appropriate organizational behavior and practice regarding quality management. Despite the apparent effect of these 14 points on both the industrial world and the practice of management theory around the world, there is little evidence of the role of the Deming management method in the formalization and advancement of management theory. Although its impact on management practice is clear, neither its theoretical contribution nor its theoretical base has yet to be articulated. Yes, there is a theory of quality management underlying the Deming management method, but at present, this theory is presented in the prescriptive form of these 14 points. We propose and articulate a theory of quality management to describe and explain the effects of adopting the Deming management method. This theory is based on the conceptual synthesis of Deming's writings, literature on the Deming management metho.
CMOS Vertical Multiple Independent Gate Field Effect Transistor (MIGFET)

Perfectly self aligned vertical multiple independent gate field effect transistor (MIGFET) CMOS devices have been fabricated. The unique process used to fabricate these devices allow them to be integrated with FinFET devices. Device and circuit simulations have been used to explain the device and explore new applications using this device. A novel application of the MIGFET as a signal mixer has been demonstrated. The undoped channel, very thin body, perfectly matched gates allows charge coupling of the two signals and provide a new family of applications using the MIGFET mixer. Since the process allows integration of regular CMOS double gate devices and MIGFET devices this technology has potential for various digital and analog mixed-signal applications.
Amino acid substitution mutations in the herpes simplex virus ICP27 protein define an essential gene regulation function

ICP27 is an essential herpes simplex virus type 1 (HSV-1) alpha protein that is required for the transition from the beta to the gamma phase of infection. To identify functional regions of ICP27, we constructed 16 plasmids that contain nucleotide substitution mutations in the ICP27 gene. The mutations created XhoI restriction sites, altered one or two codons, and were spaced at semiregular intervals throughout the coding region. Three mutations completely inactivated an essential function of ICP27, as demonstrated by the inability of the transfected plasmids to complement the growth of an HSV-1 ICP27 deletion mutant. These mutations, M11, M15, and M16, mapped in the carboxyl-terminal one-third of ICP27 at residues 340 and 341, 465 and 466, and 488, respectively. In cotransfection assays, all three defective-plasmid mutants retained the transrepression function of ICP27 but were defective at transactivation. To define the lytic functions that are mediated by the transactivation activity of ICP27, we engineered HSV-1 recombinants containing the M11, M15, or M16 mutation. All three viral mutants failed to grow in Vero cells and possessed similar phenotypes. The viral mutants replicated their DNA similarly to the wild-type virus but showed several defects in viral gene expression. These were a failure to down-regulate alpha and beta genes at late times after infection and an inability to induce certain gamma-2 genes. Our results demonstrate that the transactivation function of ICP27 (as it is defined in cotransfection assays) mediates an essential gene regulation function during the HSV-1 infection. This activity is not required for ICP27-dependent enhancement of viral DNA replication. Our work supports and extends previous studies which suggest that ICP27 carries out two distinct regulatory activities during the HSV-1 infection.
Prescription pattern of antidepressants in out-patient psychiatric practice

SYNOPSIS The prescription pattern of antidepressants was reviewed in a large sample of psychiatric out-patients in the Region of Piedmont. Antidepressants were administered to 780 patients; most were diagnosed with mood disorders (62% of prescriptions) and anxiety disorders (34%), the rest with other diagnoses. The mean prescribed dose of antidepressants was at the lower end of, or below, the recommended range for out-patients, with the exception of amineptine and mianserin. The administered dose of tricyclic antidepressants was significantly associated with sex and diagnosis: female patients received a daily dose that was significantly lower than that for males, and patients with a diagnosis of mood disorders received significantly more medication than those with other diagnoses.
Natural and anthropogenic variation in coarse wood among and within lakes

1 Residential development is often concentrated near aquatic ecosystems and understanding riparian–littoral zone interactions is therefore critical for assessing its ecological effects. 2 Introduction of wood from riparian forests into the littoral zone, where it becomes habitat for aquatic organisms, is an important, but poorly understood, process. We related the density of littoral coarse wood both among and within 45 lakes in Vilas County, Wisconsin, USA, to forest structure, abiotic drivers and land use. 3 Among all lakes and among a subset of low‐development lakes, the best predictor of the density of littoral coarse wood was the density of riparian coarse wood. At the within‐lake (site) level, two alternative models explain variability in coarse wood abundance: as a function of exposure to wind and amount of riparian coarse wood or as a function of exposure to wind and land‐use intensity. 4 Both among and within lakes, areas more modified by humans had a lower density of littoral coarse wood. Conversely, areas with little (current) human impact were tremendously variable; some sites and lakes had abundant wood and others had virtually none. 5 Contrary to previous studies, there was no relationship between living trees and coarse wood density, suggesting that riparian and littoral coarse wood densities may be strongly influenced by past disturbance, both human and natural. 6 This study highlights the importance of cross boundary subsidies in understanding the impact of development on ecosystems. The concentration of residential development at the boundary between terrestrial and aquatic ecosystems appears to reduce the flow of coarse wood from forests to lakes. Loss of this resource may have negative consequences for lake biota and the aquatic food web.
Understanding the Fundamental Persistence of Corporate Capital Structure

When predicting future leverage ratios, the explanatory power of initial residual leverage falls quickly over time, while initial standard leverage determinants retain much of their explanatory power. To make sense of this fundamental persistence, we show that growth-type (identified by a two-way sort on firm initial market-to-book ratio and asset tangibility) can parsimoniously span significantly dispersed and persistently different leverage ratios. Different growth-types suggest persistently distinct investment styles (of tangible investments versus R&D or intangible investments). This gives rise to specific market imperfections and hence induces different financing behaviors. Therefore, growth-type plays a stable role in anchoring long-run capital structure.
Malaysia’s branding as an Islamic tourism hub: An assessment

Malaysia is attempting to be a popular Islamic tourist destination in the world owing to its Islamic environment. It is already noted as an Islamic country serious in establishing a halal hub for financial products as well as services. As a further step forward it is embracing novel concepts such as Islamic and halal tourism in recent years. While the country does have the potentials of advancing Islamic tourism and hospitality industry with respect to the arts, heritage and unique culture of the Malay Muslims, the evaluation of such strategic branding efforts has rarely been attempted. This study outlines Malaysia’s marketing efforts in branding itself as an Islamic tourism hub. A SWOT analysis was conducted to summarize the country’s internal (strengths and weaknesses) and external (opportunities and threats) issues in branding itself as an Islamic destination. Keywords: branding, halal, Islamic hub, Islamic tourism, Malaysia, SWOT analysis
Service needs and barriers to care five or more years after moderate to severe TBI among Veterans

ABSTRACT Primary objective: The objective of this paper is to identify the most frequent service needs, factors associated with needs, and barriers to care among Veterans and service members five or more years after moderate to severe traumatic brain injury (TBI). Research design: Survey administered via telephone 5–16 years after injury (median eight years) and subsequent acute inpatient rehabilitation at a regional Veterans Affairs (VA) medical centre. Methods and procedures: Participants were 119 Veterans and military personnel, aged 23–70 (median 35), 90% male. Demographics, injury characteristics, service needs, whether needs were addressed, barriers to care, health and general functioning were assessed. Main outcomes and results: The most frequent needs were for help with memory, information about available services and managing stress. Obtaining information about services was the most consistently un-addressed need; managing stress was the most consistently addressed need. Cognitive and psychiatric symptoms and alienation from community were associated with needs going un-addressed. Participants treated after an expansion of TBI services at the study site reported fewer un-addressed needs. Not knowing where to get help was the most common barrier to care. Conclusion: Repeated outreach, assessment of needs and education about available services are needed throughout Veterans’ lifespan after moderate to severe TBI.
On The Role Of Normative Influences In Commercial Virtual Communities

The potential to reconcile economic benefits to the firm with the social needs of customers has made commercial virtual communities a popular tool for companies to support their core products/service with a value-added service option. An important key to the success of such a virtual community is the behavior of its members. In this paper, we develop a framework of pro-social behavior (i.e., community citizenship behavior and contribution intentions) for understanding and explaining the motivation of virtual community members to actively participate in and care for the community. We show that the main determinants of pro-social behavior are the social norm of reciprocity and the personal norm of obligation. Reciprocity, in turn, is impacted by the value of the information and the socio-emotional support exchanged by the virtual community members.
Detection and enumeration of circulating tumour cells in colorectal cancer

Sir I read with interest the article by Dr Olsen and colleagues on the value of laparoscopy before appendicectomy in women (Br J Surg 1993; 80: 922-3). The use of laparoscopy in the diagnosis and treatment of acute appendicitis is becoming widespread in this country and elsewhere in the world. Although this technique is very useful in confirming acute appendicitis and also in diagnosing other pathologies (especially gynaecological ones), practising surgeons must be wary of the ‘laparoscopically normal’ appendix. Dr Olsen and colleagues used the criterion that appendicitis could be excluded ‘if a normal appendix could be seen throughout its length’. However, a recent study by Grunewald and Keating’ showed that, at open operation, surgeons diagnosed a normal appendix incorrectly in 26 per cent of patients when it was subsequently checked histologically. Furthermore, when the appendix appeared normal and no other pathology could be found, the false-reassurance rate rose to 29 per cent. The laparoscope affords excellent views of much of the peritoneal cavity and allows visualization of the pelvic organs while causing minimal morbidity to the patient. It also magnifies the appendix, allowing very close inspection of this structure. Unfortunately, there are no data to show conclusively that laparoscopic assessment of the ‘normal’ appendix is any more accurate than inspection at open operation. My own attempts at assessing the turgidity of the ‘normal’ looking appendix via the laparoscope (the ‘wobbly’ sign) and comparing this with subsequent histological findings in an attempt to identify the hidden inflammation has shown no correlation. TherefoJe, in the face of such a high false-reassurance rate it is inadvisable at present to leave a laparoscopically normal appendix, especially if the clinical picture is suspicious of appendicitis and no other cause of pain can be identified.
Multimodality FDG PET/CT Appearance of Pulmonary Tuberculoma Mimicking Lung Cancer and Pathologic Correlation in a Tuberculosis-Endemic Country

Objectives: Differentiation between pulmonary tuberculoma and malignancy by preoperative diagnostic imaging sometimes proves difficult. The purpose of this study is to investigate variable manifestations of pulmonary tuberculoma mimicking lung cancer on fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) image and pathologic correlation. Patients and Methods: Twenty-five patients with a high suspicion of malignancy and histopathologically diagnosed as pulmonary tuberculoma were included. Their FDG PET/CT images, clinical data, and pathologic findings were investigated. Results: There were 18 men and seven women. The mean age was 52 ± 8.8 years. The maximal diameter of pulmonary tuberculoma ranged from 1.7 to 4.2 cm. CT scan revealed that abnormal signs associated with malignancy such as spicular radiation, notching, and pleural indentation also frequently manifested in tuberculoma. During early imaging, positive FDG uptake was identified in 21 patients (84%), intermediate uptake in 3 patients (12%) and negative uptake in 1 patient (4%). During delayed imaging, 16 patients (64%) showed persistent elevated FDG accumulation and 8 patients (32%) experienced a slight drop of FDG accumulation. Pathologically active tuberculoma showed significantly higher FDG radioactivity during both early and delayed imaging than inactive lesion (P < 0.05). Lymphadenopathy with positive FDG uptake was identified in nine patients (36%). Conclusion: Pulmonary tuberculomas mimicking lung cancer, most of which were pathologically active lesions, commonly displayed abnormal appearances in CT scan and an increase in FDG uptake, similar to changes seen on malignancy. Coexistent lymphadenopathy made differential diagnosis even more complicated. These results suggested that positive FDG PET/CT findings should be interpreted with caution in tuberculosis-endemic regions.
Determinants of GRI G3 Application Levels: The Case of the Fortune Global 500

The objectives of this research are to analyze the determinants for the adoption of the Global Reporting Initiative (GRI) G3 guidelines and GRI G3 application levels (undeclared, C, C+, B, B+, A, A+). Content analysis of the 2009 sustainability reports published by the world's 500 largest companies (Fortune Global 500) was conducted. Based on legitimacy theory and signalling theory, the study yielded two main findings. First, the binary logistic regression reveals that the adoption of GRI G3 guidelines is influenced by company size, profitability, business culture of a country, and industry. These results are consistent with past research on the factors influencing sustainability reporting. Second, the ordinal logistic regression shows that the GRI G3 application level is influenced by the industry in which a firm operates but not by company size, profitability or business culture of a country. In high-risk industries, the GRI G3 application level is more likely to be considered as a signal to manage the reputational risk of the companies. Copyright © 2012 John Wiley & Sons, Ltd and ERP Environment.
Résumé Writing in Russia and the Newly Independent States

This article examines the teaching of résumé writing at one university in Russia and several institutions in the Newly Independent States (NIS). The authors explore challenges including variable cultural norms for written versus oral communication, severe financial and material hardship in the educational sector, cultural discomfort with the norms of U.S. business writing, issues related to the transition from Soviet-style socialism to Western-style capitalism, and other historical factors that shape expectations for business communication in Russia and the NIS. Recommendations to business writing and communication faculty conclude the article.
Effects of Nitrogen and Phosphorus Limitation on the Activated Sludge Biomass in a Kraft Mill Biotreatment System

Unlike wastewater, pulp and paper mill effluents are generally severely deficient in bioavailable nitrogen and phosphorus. The influence of nitrogen and phosphorus limitations on steady‐state or typical pulp and paper mill activated sludge floc properties and performance was studied using a bioreactor‐fed synthetic raw mill effluent and seeded with mill activated sludge. Limitation of either nitrogen or phosphorus decreased growth, five‐day biochemical oxygen demand, and suspended solids removal. Nitrogen limitation greatly enhanced activated sludge floc poly‐β‐hydroxybutyrate (PHB), but not carbohydrate or extracellular polymeric substances (EPS). In contrast, phosphorus limitation increased total floc carbohydrate and EPS, but not PHB. The flocs showed little ability to store either nitrogen or phosphorus. Nitrogen limitation, but not phosphorus limitation, produced much more negative net floc surface charge, increasing fines, while phosphorus limitation, but not nitrogen limitation, increased the floc bound water content and surface hydrophobicity and decreased fines.
Obesity and heart disease: a statement for healthcare professionals from the Nutrition Committee, American Heart Association.

Obesity is an increasingly prevalent metabolic disorder affecting not only the US population but also that of the developing world. It is estimated from the third National Health and Nutrition Examination Survey (NHANES III) (1988-1991) that 33% of the US population is obese, compared with 25% in NHANES II (1976-1980). 1 Fatness is associated with a number of comorbidities, including several forms of heart disease. Although heredity explains 30% to 70% of cases of obesity, environmental contributions to the increasing prevalence of obesity must be sought since the gene pool has remained stable over the same interval. Diets high in fat (and calories)2 and a reduced expenditure of energy in the form of physical activity3 are the most likely explanations. However, in the United States, despite the reduction in consumption of fat from approximately 40% of calories in 1965 to 34% of calories in 1991,4 a decrease in incidence of obesity has not occurred. This is likely attributable to both maintenance of fat intake with an increase in total caloric intake and reduced physical activity. Interestingly, in developing countries some comorbidities are seen at a lesser degree of excess weight, suggesting that relative weight may be as important as absolute adiposity. The definition of obesity, or being overweight,5 remains controversial. In the United States, mortality data provided by the Metropolitan Life Insurance Company historically have been used to define obesity.6 Yet these data relate to mortality only, and the definition depends on a person’s frame (size), which is arbitrary and not independently related to obesity-related mortality or comorbidities. Body mass index (BMI) has recently gained favor as a better measure of adiposity.7 8 BMI is defined as weight in kilograms divided by height in meters squared (kg/m2). A threshold level of BMI to …
Desmosomal localization of β-catenin in the skin of plakoglobin null -mutant mice

e Plakoglobin, a protein belonging to the Armadillo-repeat gene family, is the only component that adherens junctions and desmosomes have in common. Plakoglobin null-mutant mouse embryos die because of severe heart defects and may exhibit an additional skin phenotype, depending on the genetic background. Lack of plakoglobin affects the number and structure of desmosomes, resulting in visible defects when cells are subjected to increasing mechanical stress, e.g. when embryonic blood starts circulating or during skin differentiation. By analysing plakoglobinnegative embryonic skin differentiation in more detail, we show here that, in the absence of plakoglobin, its closest homologue, β-catenin, becomes localized to desmosomes and associated with desmoglein. This substitution may account for the relatively late appearance of the developmental defects seen in plakoglobin null-mutant embryos. β-catenin cannot, however, fully compensate a lack of plakoglobin. In the absence of plakoglobin, there was reduced cell-cell adhesion, resulting in large intercellular spaces between keratinocytes, subcorneal acantholysis and necrosis in the granular layer of the skin. Electron microscopic analysis documented a reduced number of desmosomes, and those present lacked the inner dens plaque and had fewer keratin filaments anchored. Our analysis underlines the central role of plakoglobin for desmosomal assembly and function during embryogenesis.
FACTORS THAT INFLUENCE E-LOYALTY OF INTERNET BANKING USERS

The objective of this study was to examine factors that influence customer e-loyalty. In this respect, we identified three factors that may influence customer e-loyalty, namely trust, customer satisfaction, and sense of belonging. We used Internet banking as the target technology and college students as subjects for this study. One hundred and nineteen questionnaires were used for the data analysis and multiple regression analyses were conducted to analyze the data. Trust, customer satisfaction, and sense of belonging were found to have a significant impact on customer e-loyalty in Internet banking. To cite this document: Ameen M Al-Agaga and Khalil Md Nor, "Factors that influence e-loyalty of internet banking users", International Journal of Electronic Commerce Studies, Vol.3, No.2, pp.297-304, 2012. Permanent link to this document: http://dx.doi. org/10.7903/ijecs.1097
Enabling Collaborative Solutions Across the Semiconductor Manufacturing Ecosystem

A qualitative empirical study of 29 semiconductor manufacturer and supplier firms investigates the challenges associated with implementing lean practices that require broadly based collaboration across firms. The study's primary contribution is a model of the semiconductor manufacturing ecosystem, which shows how chipmakers, suppliers of enabling technologies, subsystem suppliers, and their respective competitors interact to develop the right technologies at the right time. The study finds that the biggest challenge to industry-wide collaboration is managing knowledge flows between users and suppliers in a manner that allows all parties to collaborate without losing competitive advantage. The paper also presents insights into how inter-organizational knowledge is created synchronously in the semiconductor industry. Finally, the paper makes suggestions as to how interfirm knowledge can be managed.