Miracle-dz/UniFAR-FTUs huggingface dataset:
Patterns and Profiles of Adolescent Tobacco Users: Results From the Virginia Youth Survey

Abstract Background Cigarette smoking has decreased to a record low among youth across the United States, including in Virginia. Rates of alternative tobacco use, however, are rising and polytobacco use is common. A better understanding of the shifting use patterns and associated risk factors is important for informing tobacco prevention, cessation, and policy efforts. Methods Weighted data from the 2013 Virginia Youth Survey were used. The sample was limited to 1168 youth who reported past 30-day tobacco use of ≥1 product (cigarettes, smokeless tobacco [smokeless], or cigars/little cigars/cigarillos [cigars]). Latent class analysis categorized individuals based on current tobacco use frequency/intensity. Multivariable multinomial logistic regressions compared classes on demographics, other tobacco-related factors, other substance use, and health/psychosocial factors. Results The five-class model indicated the best fit with classes characterized as “Chippers” (28.0%; high probability of low-frequency/intensity cigarette use), “Moderate Poly-Users” (23.6%; low- to high-frequency/moderate intensity cigarette use; moderate probability smokeless/cigar use), “Cigar Users” (20.9%; no–low-probability cigarette/smokeless use; high-probability cigar use), “Smokeless Users” (17.3%; no–low-probability cigarette/cigar use; moderate–high-probability smokeless use), and “Heavy Poly-Users” (10.4%; daily/high-intensity cigarette use, moderate–high-probability smokeless/cigar use). Classes differed significantly by demographics and inconsistently by other tobacco-related factors. Heavy Poly-Users were more likely to engage in other substance use behaviors, report suicidal ideation, and report being bullied because of gender. Conclusions Classes identified indicate that a large proportion of youth engage in polytobacco use and certain subgroups may be at greater risk for negative health consequences due to elevated psychosocial and behavioral risk factors. Implications These findings suggest distinct patterns of current tobacco use, including a high proportion of youth engaging in polytobacco use. Heavy polytobacco use co-occurs with other health risk behaviors and may be attributed to psychosocial risk factors. Results underscore the need for detailed monitoring of shifting youth tobacco use patterns as well as targeted prevention, cessation, and policy efforts.
Standardized classification and reporting of glomerulonephritis

A kidney biopsy is done to determine the etiology of the glomerulonephritis (GN) and the severity of the lesion, to identify whether other lesions, related to or not related to the GN, are present on the kidney biopsy and finally to ascertain the extent of chronicity of the GN. The etiology of GN is based on the classification of GN into five groups: immune complex-mediated GN, antineutrophil cytoplasmic antibody (ANCA)-associated GN, anti-glomerular basement membrane (GBM) GN, monoclonal immunoglobulin-mediated GN and C3 glomerulopathy. Immune complex GN includes multiple specific diseases such as lupus nephritis, IgA nephropathy, infection-related GN and fibrillary GN. ANCA GN, anti-GBM GN and C3 glomerulopathy are specific diseases in themselves, while monoclonal Ig GN includes proliferative GN with monoclonal Ig deposits and monoclonal Ig deposition disease. Thus identification of the class of GN and within it the specific disease determines the etiology of GN. Ancillary studies may be required to confirm the etiology of GN. The severity of the GN is revealed by the pattern of injury, such as crescentic, necrotizing, diffuse proliferative, exudative, membranoproliferative, mesangial proliferative or a sclerosing GN. Secondary diagnosis either related or unrelated to the GN, such as diabetic glomerulosclerosis, acute tubular necrosis or thrombotic microangiopathy, may also be present. The secondary diagnosis may sometimes be the reason for the kidney biopsy. The chronicity of GN is determined by evaluating the extent of glomerulosclerosis, tubular atrophy and interstitial fibrosis and vascular sclerosis present on the biopsy. This review summarizes the approach to standardizing a kidney biopsy report that includes these components in a logical and sequential manner.
The Risk Factor Analysis for the Late Graft Failure of Radial Artery Graft in Coronary Artery Bypass Grafting

Objective: The aim of this retrospective study was to investigate the early operative results and detect the factors influencing the fate of radial artery grafts (RAGs) by evaluating the mid-term patency. Methods: We retrospectively reviewed 410 patients who underwent isolated coronary artery bypass grafting using RAG. RAGs were anastomosed to 526 coronary arteries. Mid-term angiography was performed in 214 patients at an average 4.9 years after the operation. Results: The early patency of RAGs was 97.6%. Cumulative 5-year patency was 86.5% for RAG, 94.1% for LITA graft, and 81.0% for saphenous vein graft (SVG). RAG was significantly superior to SVG in mid-term patency. Individual grafting (not sequential grafting) (hazard ratio [HR]: 2.535; 95% confidence interval [CI]: 1.293–5.281; p = 0.006) and grafting to the target coronary artery with ≤75% proximal stenosis (HR: 1.947; 95% CI: 1.090–3.484; p = 0.025) were found to be independent risk factors influencing late RAG patency. Conclusions: The patency of RAGs was superior to that of SVGs in the studied population. When using RAGs, grafting to the target vessel with severe proximal stenosis is favorable. The RAG is suitable for sequential grafting.
Editorial on "upfront surgery as first-line therapy in selected patients with stage IIIA non-small cell lung cancer".

In many countries, lung cancer is still the leading cause of cancer deaths, as many patients are diagnosed with cancer at an advanced stage (III or IV). Non-small cell lung cancer (NSCLC) accounts for 85% of lung cancer cases. Treatment for patients with stage IIIA NSCLC remains one of the most challenging areas in thoracic surgery. During the last two decades, many clinical studies have focused on chemotherapy, radiotherapy, or chemoradiotherapy combined with or without surgery. However, optimal management of clinical stage IIIA NSCLC is still controversial in clinical practice (1).
Feasibility and Safety of Transtympanic Balloon Dilatation of Eustachian Tube.

OBJECTIVE Assess safety and feasibility of transtympanic dilatation of proximal (tympanic-end) of the cartilaginous segment of the Eustachian tube in patients undergoing surgery for chronic ear disease. STUDY DESIGN Case series. SETTING Tertiary care hospital. SUBJECT AND METHODS We reviewed the charts of 40 consecutive patients undergoing chronic ear surgery in our practice with manometric evidence of obstruction who underwent attempted transtympanic dilatation of proximal (tympanic-end) segment of the Eustachian tube. A range of outcome measures were reported that included pre and postdilatation opening pressure measurement of the Eustachian tube, closure of perforation, audiometric data, and complications. RESULTS Dilatation of proximal (tympanic-end) of the cartilaginous segment of the Eustachian tube was technically feasible in 37 of 40 patients (93%). Postdilatation inspection of protympanum showed increased aperture in all dilated tubes. Opening pressure of Eustachian tube declined in 36 of 37 patients (97%). Residual perforation was evident in 5 of 40 patients (12%). No facial nerve or carotid complications were observed. Two patients had severe dizziness (5%) with one patient sustaining severe cochlear loss. CONCLUSION Transtympanic dilatation increases the patency of the Eustachian tube immediately after instrumentation. No carotid complications were observed. Continuous endoscopic control is essential to avoid subluxation of stapes. Further study of this technique is warranted to identify its role, if any, in chronic ear surgery.
Indirect Co-Culture of Testicular Cells with Bone Marrow Mesenchymal Stem Cells Leads to Male Germ Cell-Specific Gene Expressions

Objective Non-obstructive azoospermia is mostly irreversible. Efforts to cure this type of infertility have led to the application of stem cells in the reproduction field. In the present study, testicular cell-mediated differentiation of male germ-like cells from bone marrow-derived mesenchymal stem cells (BM-MSCs) in an in vitro indirect co-culture system is investigated. Materials and Methods In this experimental study, mouse BM-MSCs were isolated and cultured up to passage three. Identification of the cells was evaluated using specific surface markers by flow-cytometry technique. Four experimental groups were investigated: control, treatment with retinoic acid (RA), indirect co-culture with testicular cells, and combination of RA and indirect co-culture with testicular cells. Finally, following differentiation, the quantitative expression of germ cell-specific markers including Dazl, Piwil2 and Stra8 were evaluated by real-time polymerase chain reaction (PCR). Results Molecular analysis revealed a significant increase in Dazl expression in the indirect co-culture with testicular cells group in comparison to the control group. Quantitative expression level of Piwil2 was not significantly changed in comparison to the control group. Stra8 expression was significantly higher in RA group in comparison to other groups. Conclusion Indirect co-culture of BM-MSCs in the presence of testicular cells leads to expression of male germ cell-specific gene, Dazl, in the induced cells. Combination of co-culture with testicular cells and RA did not show any positive effect on the specific gene expressions.
Land‐use change promotes avian diversity at the expense of species with unique traits

Abstract Land‐use change may alter both species diversity and species functional diversity patterns. To test the idea that species diversity and functional diversity changes respond in differing ways to land‐use changes, we characterize the form of the change in bird assemblages and species functional traits along an intensifying gradient of land use in the savanna biome in a historically homogeneous vegetation type in Phalaborwa, South Africa. A section of this vegetation type has been untransformed, and the remainder is now mainly characterized by urban and subsistence agricultural areas. Using morphometric, foraging and breeding functional traits of birds, we estimate functional diversity changes. Bird species richness and abundance are generally higher in urban and subsistence agricultural land uses, as well as in the habitat matrix connecting these regions, than in the untransformed area, a pattern mainly driven through species replacement. Functionally unique species, particularly ground nesters of large body size, were, however, less abundant in more utilized land uses. For a previously homogenous vegetation type, declines in the seasonality of energy availability under land‐use change have led to an increase in local avian diversity, promoting the turnover of species, but reduced the abundance of functionally unique species. Although there is no simple relationship between land‐use and diversity change, land‐use change may suit some species, but such change may also involve functional homogenization.
Age Differences in Spatial Memory for Mediated Environments

Compared with younger adults, older adults have more difficulty with navigation and spatial memory in both familiar and unfamiliar domains. However, the cognitive mechanisms underlying these effects have been little explored. We examined three potential factors: (a) use of and coordination across spatial reference frames, (b) nonspatial cognitive abilities, and (c) the ability to segment a route into effective chunks. In two experiments, healthy young and older adults watched videos of navigation in a novel environment and had to remember the placement of landmarks along the route. Participants completed three spatial memory tasks—a virtual pointing task, a distance estimation task, and sketch map drawing—for each route. The pointing task depends on updating and accessing the updated egocentric reference frame relative to other frames. Map drawing may rely more on environment-centered processing. The distance estimation task could be solved using either frame of reference. Last, participants segmented each route. In a separate session, working memory, processing speed, and verbal memory were assessed. Older adults performed less well on all spatial tasks compared with younger adults; aging had a stronger negative effect on pointing performance. This may point to impairments in older adults’ ability to update and coordinate information across reference frames. Performance on all spatial tasks was predicted by nonspatial task performance. Segmentation did not predict spatial memory. These results underline the importance of situating age differences in navigation in the context of basic transformations of spatial reference frames, and also in the context of nonspatial cognitive abilities.
Effects of reproductive period duration and number of pregnancies on midlife ECG indices: a secondary analysis from the Women’s Health Initiative Clinical Trial

Objectives Pregnancy, menses and menopause are related to fluctuations in endogenous sex hormones in women, which cumulatively may alter cardiac electrical conduction. Therefore, we sought to study the association between number of pregnancies and reproductive period duration (RD, time from menarche to menopause) with ECG intervals in the Women’s Health Initiative Clinical Trials. Design Secondary analysis of multicentre clinical trial. Setting USA. Primary outcome measures ECGintervals: PR interval, P-wave duration, P-wave dispersion, QTc interval. Participants n=40 687 women (mean age=62 years) participating in the Women’s Health Initiative Clinical Trials. 82.5% were white, 9.3% black, 4% Hispanic and 2.7% Asian. Methods In primary analysis, we employed multivariable linear regression models relating number of pregnancies and RD with millisecond changes in intervals from enrolment ECG. We studied effect modification by hormone therapy use. Results Among participants, 5+ live births versus 0 prior pregnancies was associated with a 1.32 ms increase in PR interval (95% CI 0.25 to 2.38), with a graded association with longer QTc interval (ms) (none (prior pregnancy, no live births)=0.66 (–0.56 to 1.88), 1=0.15 (–0.71 to 1.02), 2–4=0.25 (–0.43 to 0.94) and 5+ live births=1.15 (0.33 to 1.98), p=0.008). RD was associated with longer PR interval and maximum P-wave duration (but not P-wave dispersion) among never users of hormone therapy: (PR (ms) per additional RD year: 0.10 (0.04 to 0.16); higher P-wave duration (ms): 0.09 (0.06 to 0.12)). For every year increase in reproductive period, QTc decreased by 0.04 ms (−0.07 to –0.01). Conclusions An increasing number of live births is related to increased and RD to decreased ventricular repolarisation time. Both grand multiparity and longer RD are related to increased atrial conduction time. Reproductive factors that alter midlife cardiac electrical conduction system remodelling in women may modestly influence cardiovascular disease risk in later life. Trial registration number NCT00000611; Post-results.
Female gender and left ventricular dysfunction in myocardial surgical revascularization: the strange couple.

Congestive heart failure (CHF) a chronic progressive condition, needing lifelong management, associated with poor outcome and shortened survival, is the first cause of hospitalization in the elderly (1-3). Although data from Framingham Heart Study have historically identified arterial hypertension as the primary cause of heart failure (1,2,4), more recent studies suggest that in the developed country, coronary artery disease (CAD) and its complications have become the most common cause of progressive development of severe left ventricular dysfunction with reduced ejection fraction (EF) (1,3,5,6).
Outcome of Vitrectomy Surgery in Dropped Nucleus at Jakarta Eye Center

Introduction: To report management and outcome of dropped nucleus in Jakarta Eye Center Methods: Retrospective review of the records of 19 consecutive patients who underwent pars plana vitrectomy for retain lens fragments at Jakarta Eye Center from January 2010 to September 2012. Result: The mean age of the patient was 57 years (range 48-79). There were 10 males (53%) and 9 females (47%). 10 patients (53%) had vitrectomy within 1 day of phacoemulsification, 6(32%) within 1 week and 3(15%) after more than 1 week. Eight patients (42%) achieved a final visual acuity of 0.5 or better, only 3 patients (15%) had final visual acuity 1-meter finger counting or worse. 74% patient achieved final acuity better than pre-op (14 patients). Early vitrectomy group has 3 patients (30%) with complication, intermediate vitrectomy group has 33% complication and late vitrectomy has 33 % complication. Posterior chamber IOL were implanted in 12 patients (63%), 2 patients had scleral fixation IOL, anterior chamber IOL in 2 patients, and only 3 patients (16%) were left aphakic. Conclusion: Surgical management in cases of nucleus drop in JEC showed good result with very limited complications. In most cases, vitrectomy was performed immediately after cataract surgery. Early vitrectomy has no significant differences in complications and visual outcome than 1 week vitrectomy and late vitrectomy after cataract surgery.
Evaluation of the Performance of Different Traps for Sampling Usutu and West Nile Viruses and Mosquito (Diptera: Culicidae) Vectors in Senegal

Abstract An efficient trapping tool is one of the most important factors in surveillance and research on arboviruses and their vectors. In the current study, we tested the efficiency of several traps for sampling West Nile (WNV) and Usutu (USUV) viruses and their vectors in Senegal during 2013. A total of 15,527 mosquitoes (Diptera: Culicidae), 94.3% females, were collected. Among the known arbovirus vectors, Mansonia uniformis (Theobald) (Diptera: Culicidae) was the most abundant (46.5%), followed by Culex poicilipes Theobald (Diptera: Culicidae) (19.5%), Culex tritaeniorhynchus Giles (Diptera: Culicidae) (8.0%), and Culex neaveiTheobald (Diptera: Culicidae) (6.1%). The geometric means of these vectors varied by trap, location, and height. WNV was isolated from Cx. neavei and Cx. tritaeniorhynchus collected by pigeon-baited traps within the canopy, CO2-CDC traps within the canopy and at the ground. USUV was isolated only from Cx. neavei collected by pigeon-baited traps and CO2-CDC traps within the canopy. Therefore, for each study, the trap to be chosen will depend on the mosquito species and virus targeted.
Interpersonal Insecurity and Risk-Taking Propensity Across Domains and Around the Globe

During social interactions, individuals frequently experience interpersonal insecurity, including feelings of not being loved, protected, trusted, or cared for; these feelings cause numerous behavioral consequences. The present research explores the relationship between interpersonal insecurity and risk-taking propensity in multiple risk domains and around the globe based on risk-sensitivity theory and research on group identity. In Study 1, participants (N = 209) reported their interpersonal insecurity and risk-taking propensity across seven risk domains. The results show that risk-taking propensity generally increases with interpersonal insecurity. However, this relationship was negative in the cooperation domain and null in the financial domain. In Study 2 (N = 128,162), data from the World Values Survey from 77 countries reveal a positive correlation between risk-taking propensity and interpersonal insecurity with in-group members but a negative relationship between risk-taking propensity and interpersonal insecurity with out-group members.
Inequality and Mobility Using Income, Consumption, and Wealth for the Same Individuals

Recent studies of economic inequality almost always separately examine income inequality, consumption inequality, and wealth inequality, and hence, these studies miss the important synergy between the three measures explicit in the life-cycle budget constraint. Using the Panel Study of Income Dynamics (PSID), we study inequality in three dimensions, focusing on the conjoint distributions of income, consumption, and wealth for the same individuals. We find that the trends in inequality in income, consumption, and wealth similarly increase between 1999 and 2013. We examine the pairwise distributions of our measures using the average propensity to consume and the wealth-income ratios. Using the longitudinal nature of the PSID, we follow people over this period and find mobility is similar using income, consumption, and wealth. We conclude that while all three types of inequality are rising, wealth increasingly acts as a buffer to cushion income changes, which could reduce mobility—both intra- and inter-generational mobility.
Multiple generalist morphs of Lake Trout: Avoiding constraints on the evolution of intraspecific divergence?

Abstract A generalist strategy, as an adaptation to environmental heterogeneity, is common in Arctic freshwater systems, often accompanied, however, by intraspecific divergence that promotes specialization in niche use. To better understand how resources may be partitioned in a northern system that supports intraspecific diversity of Lake Trout, trophic niches were compared among four shallow‐water morphotypes in Great Bear Lake (N65° 56′ 39″, W120° 50′ 59″). Bayesian mixing model analyses of stable isotopes of carbon and nitrogen were conducted on adult Lake Trout. Major niche overlap in resource use among four Lake Trout morphotypes was found within littoral and pelagic zones, which raises the question of how such polymorphism can be sustained among opportunistic generalist morphotypes. Covariances of our morphological datasets were tested against δ13C and δ15N values. Patterns among morphotypes were mainly observed for δ15N. This link between ecological and morphological differentiation suggested that selection pressure(s) operate at the trophic level (δ15N), independent of habitat, rather than along the habitat‐foraging opportunity axis (δ13C). The spatial and temporal variability of resources in Arctic lakes, such as Great Bear Lake, may have favored the presence of multiple generalists showing different degrees of omnivory along a weak benthic–pelagic gradient. Morphs 1–3 had more generalist feeding habits using both benthic and pelagic habitats than Morph 4, which was a top‐predator specialist in the pelagic habitat. Evidence for frequent cannibalism in Great Bear Lake was found across all four morphotypes and may also contribute to polymorphism. We suggest that the multiple generalist morphs described here from Great Bear Lake are a unique expression of diversity due to the presumed constraints on the evolution of generalists and contrast with the development of multiple specialists, the standard response to intraspecific divergence.