Miracle-dz/UniFAR-FTUs huggingface dataset:
Illness perception among hypertensive patients in primary care centre UKMMC.

INTRODUCTION Hypertension is one of the chronic diseases with a rising trend globally, including Malaysia. Patients' own perception of their illness is a strong factor that determines their health-seeking behaviour. The objective of this study was to evaluate the illness perception of hypertensive patients and the associated factors. METHOD A cross-sectional study was conducted among 250 hypertensive patients who were randomly sampled at the Primary Care Centre of the Universiti Kebangsaan Malaysia Medical Centre (PCC UKMMC) from October 2011 to January 2012. All respondents completed a self-administered questionnaire comprising three sections: (1) Socio-demographic data, (2) Illness perception score, measured using the Malay version of Brief Illness Perception Questionnaire (BIPQ) and (3) Malay version of depression and anxiety, assessed by the Hospital Anxiety and Depression Scale (HADS). Data entry and analysis were done using Statistical Package for Social Sciences (SPSS) version 19.0. RESULTS The total illness perception score was significantly higher among Malay 5.13 (95% CI: 2.21, 8.05), those with positive family history 5.43 (95% CI: 2.14, 8.72) and respondents who have anxiety 8.56 (95% CI: 4.39, 12.73). CONCLUSION Primary care providers need to identify these three significant factors that are associated with patients' illness perception when managing hypertensive patients. Steps need to be taken to screen and treat anxiety among this group of patients.
A Short-Term, Quasi-Experimental Evaluation of D.A.R.E.'s Revised Elementary School Curriculum

We present the short-term results of a quasi-experimental evaluation of the revised D.A. R.E. (Drug Abuse Resistance Education) curriculum. Study outcomes examined were D.A. R.E. 's effects on three substances, namely students' lifetime and 30-day use of tobacco, alcohol, and marijuana, as well as their school attendance and academic performance. The study comprised students in 17 urban schools, each of which served as its own control; 5th graders in the 2006–2007 school year constituted the comparison group (n = 1490), and those enrolled as 5th graders in the 2007–2008 school year constituted the intervention group (n = 1450). We found no intervention effect on students' substance use for any of the substance use outcomes assessed. We did find that students were more likely to attend school on days they received D.A. R.E. lessons and that students in the intervention group were more likely to have been suspended. Study findings provide little support for the implementation and dissemination of the revised D.A. R.E. curriculum.
Development of colorectal tumors in colonoscopic surveillance in Lynch syndrome.

BACKGROUND & AIMS Mutation carriers in Lynch syndrome families have a high risk for developing colorectal cancer during their lifetime. This study was designed to assess the cumulative risk for the development of colorectal adenoma or carcinoma in prospective colonoscopic surveillance. METHODS Data from the Finnish Hereditary Colorectal Cancer Registry electronic database on 420 Lynch syndrome mutation carriers without previous colorectal tumors were reviewed. Between March 1982 and May 2005 the mutation carriers underwent a total of 1252 colonoscopies. The total follow-up time was 3150 years (mean, 6.7 y/patient). RESULTS The cumulative risk of adenoma by age 60 was estimated as 68% (95% confidence interval [CI], 50%-80%) in men and 48% (95% CI, 29%-62%) in women. The estimated cumulative risk up to age 60 years for the development of cancer found as a result of surveillance at an interval of 2-3 years was 35% (95% CI, 16%-49%) in men and 22% (95% CI, 7%-34%) in women. Half of the adenomas were located proximal to the splenic flexure. Extracolonic cancer was diagnosed in 73 patients (18%). CONCLUSIONS Adenoma would appear to be the most important lesion preceding cancer formation in Lynch syndrome and removal of adenomas decreases the risk for colorectal cancer (CRC). The Finnish surveillance protocol of colonoscopies at 2- to 3-year intervals facilitates patient adherence but includes an essential risk for CRC up to 60 years of age, but without CRC-related mortality when the surveillance instructions are followed.
Tendinous disorders attributed to statins: a study on ninety-six spontaneous reports in the period 1990-2005 and review of the literature.

OBJECTIVE To date, statins have more often been considered a safe medication. However, with the wider use of statins, severe side effects have also been reported to occur in statin-treated patients, especially myositis and rhabdomyolysis. Currently, however, statin-associated tendon impairment has only been described anecdotally. The aim of this retrospective study was to evaluate tendon manifestations occurring in statin-treated patients. METHODS All reports in which a statin was listed spontaneously as a causative suspect medication of tendon complications in the network of the 31 French Pharmacovigilance Centers from 1990-2005 were included in this study. Data collection included patient characteristics and tendon adverse effects (time to onset of adverse effects, pattern, site of injury, and outcome). The percentage of the reports was further calculated for each statin. RESULTS Data were collected from 96 patients with a median age of 56 years; patients exhibited tendinitis (n = 63) and tendon rupture (n = 33). Tendinopathy more often occurred within the first year after statin initiation (59%). Tendon manifestations were related to atorvastatin (n = 35), simvastatin (n = 30), pravastatin (n = 21), fluvastatin (n = 5), and rosuvastatin (n = 5). Statin was reinitiated in 7 patients, resulting in recurrence of tendinopathy in all cases. CONCLUSION Our series suggests that statin-attributed tendinous complications are rare, considering the huge number of statin prescriptions. We suggest that prescribers should be aware of tendinous complications related to statins, particularly in risky situations, including physical exertion and association with medications known to increase the toxicity of statins.
Microbial growth under humic-free conditions in a supraglacial stream system on the Cotton Glacier, Antarctica

During the austral summers of 2004 and 2009, we sampled a supraglacial stream on the Cotton Glacier, Antarctica. The stream dissolved organic matter (DOM) was low (44–48 μM C) and lacked detectable humic fluorescence signatures. Analysis of the excitation emissions matrices (EEMs) indicated that amino-acid fluorophores dominated, consistent with DOM of microbial origin, with little humic-like fluorescence. In most aquatic ecosystems, humic DOM attenuates harmful UV radiation and its absence may represent an additional stressor influencing the microbial community. Nonetheless, the stream contained an active microbial assemblage with bacterial cell abundances from 2.94 × 104 to 4.97 × 105 cells ml−1, and bacterial production ranging from 58.8 to 293.2 ng C l−1 d−1. Chlorophyll-a concentrations ranged from 0.3 to 0.53 μg l−1 indicating that algal phototrophs were the probable source of the DOM. Microbial isolates produced a rainbow of pigment colors, suggesting adaptation to stress, and were similar to those from other cryogenic systems (Proteobacteria and Bacteroidetes lineages). Supraglacial streams provide an example of contemporary microbial processes on the glacier surface and a natural laboratory for studying microbial adaptation to the absence of humics.
Exploration among and within Plateaus in Greedy Best-First Search

Recent enhancements to greedy best-first search (GBFS) such as DBFS, -GBFS, Type-GBFS improve performance by occasionally introducing exploratory behavior which occasionally expands non-greedy nodes. However, most of these exploratory mechanisms do not address exploration within the space sharing the same heuristic estimate (plateau). In this paper, we show these two modes of exploration, which work across (inter-) and within (intra-) plateau, are complementary, and can be combined to yield superior performance. We then introduces a new fractal-inspired scheme called Invasion-Percolation diversification, which addresses “breadth”-bias instead of the “depth”-bias addressed by the existing diversification methods. We evaluate IP-diversification for both intra- and inter-plateau exploration, and show that it significantly improves performance in several domains. Finally, we show that combining diversification methods results in a planner which is competitive to the state-of-the-art for satisficing planning.
Seasonality of Conceptions Under Varying Conditions in a Rhesus Macaque Breeding Colony

SEASONALITY OF CONCEPTIONS UNDER VARYING CONDITIONS IN A RHESUS MACAQUE BREEDING COLONY by Ryan D.P. Dunk The University of Wisconsin-Milwaukee, 2013 Under the Supervision of Andrew J. Petto, Ph.D Rhesus macaques (Macaca mulatta) are well documented as seasonal breeders. Despite this, little is known about what factors influence seasonal reproduction in rhesus. It has been proposed that rhesus are “relaxed income breeders” (Brockman and van Schaik, 2005), which means they respond to changes in photoperiod but endogenous cues can allow deviations from photoperiod-timed seasonality. This study presents the results of a natural experiment on the influence of different housing conditions (featuring different levels of environmental exposure) on the seasonal pattern of reproduction in rhesus. Once the number of attempts was controlled for, rhesus did not exhibit a seasonal distribution in their conceptions regardless of their level of exposure to environmental cues. This indicates that no conceptual model as of yet has adequately assessed the variation in seasonal reproduction in rhesus macaques.
Antibody responses to two encephalomyocarditis virus vaccines in rhesus macaques (Macaca mulatta)

Abstract: Two groups of rhesus macaques (Macaca mulatta) housed in rodent‐controlled outdoor corrals were inoculated with two different encephalomyocarditis virus (EMCV) vaccines. One group (n = 45) received a vaccine made from an inactivated field isolate of virus cultured during an outbreak at a zoo in Florida. This vaccine produced fourfold increases in the titers of 28 animals (62%); the increases persisted for at least 18 months (last test) after a single injection of the vaccine. The other group (n = 51) received a vaccine made from an inactivated porcine field strain of the virus. This vaccine did not produce titers in any of the vaccinees.
[Validation of Diabetes Mellitus Knowledge (DKN-A) and Attitude (ATT-19) Questionnaires].

OBJECTIVE To present the cross-cultural adaptation of the Diabetes Knowledge Scale and Attitudes Questionnaires targeted to evaluate Brazilian Diabetes Mellitus patients. METHODS These questionnaires underwent the following steps: presentation, translation, back translation, semantic and idiomatic assessments, cultural and conceptual similarities and a pilot test. They were administered in two opportunities a month apart in a sample of 61 Diabetes Mellitus type-2 patients from a university hospital. The study design included a test-retest reliability of the answers, which were analyzed and estimated by means of the Kappa coefficient. RESULTS The findings suggested an adequacy of the instruments to the Portuguese language and Brazilian cultural identity. The Kappa coefficient in the reliability analysis showed levels of concordance from moderate to high (0.44 to 0.69) for most questions. CONCLUSIONS The questionnaires proved to be of very easy understanding for the studied subjects and reliable and valid for use in the evaluation of diabetes educational programs in the reality of Brazil.
Effect of T-lymphocyte suppression on the parasite burden in Leishmania major-infected, genetically susceptible BALB/c mice

Treatment of Leishmania major-infected, genetically susceptible BALB/c mice with the T-lymphocyte-immunosuppressive drug cyclosporin A (CyA) resulted in a significantly reduced parasite burden in the local site of infection and in the draining lymph nodes. These data indicate that T cells are pivotal for the propagation of L. major in vivo.
Validity Study of the Beck Anxiety Inventory (Portuguese version) by the Rasch Rating Scale Model

Our objective was to conduct a validation study of the Portuguese version of the Beck Anxiety Inventory (BAI) by means of the Rasch Rating Scale Model, and then compare it with the most used scales of anxiety in Portugal. The sample consisted of 1,160 adults (427 men and 733 women), aged 18-82 years old (M=33.39; SD=11.85). Instruments were Beck Anxiety Inventory, State-Trait Anxiety Inventory and Zung Self-Rating Anxiety Scale. It was found that Beck Anxiety Inventory's system of four categories, the data-model fit, and people reliability were adequate. The measure can be considered as unidimensional. Gender and age-related differences were not a threat to the validity. BAI correlated significantly with other anxiety measures. In conclusion, BAI shows good psychometric quality.
Robust and Reliable Multidiscipline Ship Design

Mathematical formulations of reliability-based design and robust design have been developed for addressing the presence of uncertainty during optimization. Reliability addresses the effects of uncertainty on the constraints; constraints that are influenced by uncertainty are converted into new probabilistic constraints to ensure that the optimal solution will satisfy the constraints within a prescribed reliability level. Robustness is introduced by including the effects of the mean and variance of the response of the objective function in the optimization. This paper presents a formulation for applying reliabilitybased design and robust design within a network of parallel optimizations to account for uncertainty in multidiscipline design optimization. The method for multidiscipline design optimization under uncertainty is applied to a conceptual ship design with a model of a bulk carrier from the literature. The optimization results demonstrate that reliable and robust optimization can be applied effectively to ship design, and that it is important to consider uncertainty during the multidiscipline ship design process.
Significant phenotypic variability of Muenke syndrome in identical twins

Muenke syndrome (MS), also known as Muenke nonsyndromic coronal craniosynostosis, is an autosomal dominant condition which can be distinguished from the more common forms of acrocephalosyndactyly but presents a significant variable phenotype. We report on a set of identical twins with a de novo C749G mutation in the FGFR3 gene codon 250 after a pregnancy complicated by prenatal exposure to Nortriptyline. These patients illustrate the variable expressivity of MS in association with an identical gene mutation. © 2009 Wiley‐Liss, Inc.
S-Naproxen and desmethylnaproxen glucuronidation by human liver microsomes and recombinant human UDP-glucuronosyltransferases (UGT): role of UGT2B7 in the elimination of naproxen.

AIMS To characterize the kinetics of S-naproxen ('naproxen') acyl glucuronidation and desmethylnaproxen acyl and phenolic glucuronidation by human liver microsomes and identify the human UGT isoform(s) catalysing these reactions. METHODS Naproxen and desmethylnaproxen glucuronidation were investigated using microsomes from six and five livers, respectively. Human recombinant UGTs were screened for activity towards naproxen and desmethylnaproxen. Where significant activity was observed, kinetic parameters were determined. Naproxen and desmethylnaproxen glucuronides were measured by separate high-performance liquid chromatography methods. RESULTS Naproxen acyl glucuronidation by human liver microsomes followed biphasic kinetics. Mean apparent K(m) values (+/-SD, with 95% confidence interval in parentheses) for the high- and low-affinity components were 29 +/- 13 microm (16, 43) and 473 +/- 108 microm (359, 587), respectively. UGT 1A1, 1A3, 1A6, 1A7, 1A8, 1A9, 1A10 and 2B7 glucuronidated naproxen. UGT2B7 exhibited an apparent K(m) (72 microm) of the same order as the high-affinity human liver microsomal activity, which was inhibited by the UGT2B7 selective 'probe' fluconazole. Although data for desmethylnaproxen phenolic glucuronidation by human liver microsomes were generally adequately fitted to either the single- or two-enzyme Michaelis-Menten equation, model fitting was inconclusive for desmethylnaproxen acyl glucuronidation. UGT 1A1, 1A7, 1A9 and 1A10 catalysed both the phenolic and acyl glucuronidation of desmethylnaproxen, while UGT 1A3, 1A6 and 2B7 formed only the acyl glucuronide. Atypical glucuronidation kinetics were variably observed for naproxen and desmethylnaproxen glucuronidation by the recombinant UGTs. CONCLUSION UGT2B7 is responsible for human hepatic naproxen acyl glucuronidation, which is the primary elimination pathway for this drug.
HiRes DECONVOLUTION OF SPITZER INFRARED IMAGES

Spitzer provides unprecedented sensitivity in the infrared (IR), but the spatial resolution is limited by a relatively small aperture (0.85 m) of the primary mirror. In order to maximize the scientific return it is desirable to use processing techniques which make the optimal use of the spatial information in the observations. We have developed a deconvolution technique for Spitzer images. The algorithm, “HiRes” and its implementation has been discussed by Backus et al. in 2005. Here we present examples of Spitzer IR images from the Infrared Array Camera (IRAC) and MIPS, reprocessed using this technique. Examples of HiRes processing include a variety of objects from point sources to complex extended regions. The examples include comparison of Spitzer deconvolved images with high-resolution Keck and Hubble Space Telescope images. HiRes deconvolution improves the visualization of spatial morphology by enhancing resolution (to sub-arcsecond levels in the IRAC bands) and removing the contaminating sidelobes from bright sources. The results thereby represent a significant improvement over previously-published Spitzer images. The benefits of HiRes include (a) sub-arcsec resolution (∼0.″6–0.″8 for IRAC channels); (b) the ability to detect sources below the diffraction-limited confusion level; (c) the ability to separate blended sources, and thereby provide guidance to point-source extraction procedures; (d) an improved ability to show the spatial morphology of resolved sources. We suggest that it is a useful technique to identify features which are interesting enough for follow-up deeper analysis.
Changes in Intramaxillary Sinus Pressure following Antrostomy, Draining Tubes, and YAMIK Procedures in 25 Patients Treated for Chronic Paranasal Sinusitis

When conservative therapies are not effective in treating sinus infections, alternate steps can be taken to improve paranasal cavity ventilation. These measures may include surgical procedures such as intranasal endoscopic or maxillary sinus fenestration, and other procedures such as placement of a maxillary sinus tube or a YAMIK sinus catheter. We conducted a prospective study of 25 patients to investigate the effects on the nasal mucosa of improved ventilation between the nasal and paranasal cavities. We accomplished this by comparing (1) the results of simultaneously measured nasal cavity and intramaxillary sinus pressures before and after widening of ventilation openings, (2) changes in mucociliary transport function as measured by the saccharin test, and (3) changes in nasal airway resistance. Just as multiple transit routes between the nasal cavity and maxillary sinus give rise to greater fluctuations in intramaxillary sinus pressure, and just as rapid breathing gives rise to even greater pressure fluctuations than does quiet breathing, we believe that both intranasal cavity airflow velocity and the number of ventilation openings present have an effect on the state of ventilation between the nasal cavity and maxillary sinus. We also suggest that the establishment of maxillary sinus ventilation openings improves mucociliary clearance.
Rapid diagnosis of Campylobacter pyloridis infection.

a day. At this time the platelet count was 256 x 109/l. Over the next nine days the cellulitis improved slightly, but on the ninth day a few purpuric lesions were seen on the lower limbs. These extended within 24 hours and the platelet count on the tenth day was 3 x 109/1 with a normal haemaglobin and white cell count. A bone marrow aspirate taken at this time showed hypercellularity and increased megakaryocytes, consistent with accelerated platelet destruction. Cephamandole was then stopped, four units of platelet concentrates were given, and cephalexin was started in an oral dose of Ig five times a day 12 hours later. The platelet count increased steadily thereafter and returned to normal within four days. Cephalexin was continued at the same doses during the subsequent three months and the platelet count remained normal throughout. Drug dependent platelet antibodies were shown using an immunofluorescence procedure4 with about 5 mg of cephamandole added to the incubation mixture of patient's serum and platelets. Patient's serum and the antibiotic solution were tested separately as controls. Other drugs given at the same time as cephamandole were frusemide, Slow K, sulindac, ibuprofen, panadeine, anginine, palfium, isosorbide dinitrate and rifampicin. All of these had been given for lengthy periods prior to the onset of thrombocytopenia, and with the exception of rifampicin, were continued subsequently without any adverse effects. The table shows the results of the platelet antibody immunofluorescence test (PIFT) performed in the presence of various cephalosporins and rifampicin, which was included as this was the only other drug discontinued at the same time as cephamandole. Platelet bound antibody was shown in the presence of cefaperazone and moxalactam, as well as cephamandole, but not in the presence of cefoxitin, cephalothin,
Directional differentiation of chicken primordial germ cells into adipocytes, neuron‐like cells, and osteoblasts

Primordial germ cells (PGCs) are useful for producing transgenic chickens and preserving genetic material in avian species. In this study, we investigated the in vitro differentiation potential of chicken PGCs into different cell types. For differentiation into adipocytes, chicken PGCs were cultured for 21 days in induction media containing dexamethasone, insulin and/or 3‐isobutyl‐1‐methylxanthine (IBMX), and differentiation rates ranging from 74% to 91% were identified by oil red‐O and alkaline phosphatase (ALP) staining. For differentiation into neuron‐like cells, chicken PGCs were cultured for 3 or 7 days in the induction media containing retinoic acid (RA) and IBMX, and differentiation rates ranging from 71% to 87% were identified by toluidine blue staining and immunohistochemical staining. For differentiation into osteoblasts, chicken PGCs were cultured for 15 or 21 days in the induction media containing desamethasone, β‐glycerol phosphate and/or vitamin C, and differentiation rates ranging from 47% to 79% were confirmed by Von Kossa, cytochemical and immunohistochemical staining. These data suggest that, like mammalian PGCs, chicken PGCs can differentiate into different cell types in vitro. Mol. Reprod. Dev. 77: 795–801, 2010. © 2010 Wiley‐Liss, Inc.
Mergers and Alliances in Pharmaceuticals: Effects on Innovation and R&D Productivity

This book provides an insightful view of major issues in the economics of corporate governance (CG) and mergers. It presents a systematic update on the developments in the two fields during the last decade, as well as highlighting the neglected topics in CG research, such as the role of boards, CG and public interest and the relation of CG to mergers. Two important conclusions can be drawn from this book: the first is that corporate governance systems that better align shareholders’ and managers’ interests lead to better corporate performance; second, there is an important relationship between CG structures and the quality of firm decision-making, one of the most important being the decision to merge or take over another firm.