Miracle-dz/UniFAR-FTUs huggingface dataset:
Resolution of statin-induced myalgia by correcting vitamin D deficiency: a case report

The onset of myalgia is a well-known side effect of cholesterol-lowering statins. Recent studiesa dvanced the hypothesis that reduced vitamin D levels may play a role in the onset of myalgia in statin users and potentially a vitamin D supplementation may be useful in these cases, as suggested by the present case report. A 52-year-old man with a history of smoke and successfully controlled hypertension presented with chest pain and asthenia. He was diagnosed with stable angina pectoris and discharged on atorvastatin. Due to the onset of myalgia, the dosage of atorvastatin was reduced (from 40 mg daily to 20 mg daily) and then atorvastatin was switched to rosuvastatin without symptoms improvement. Switching from rosuvastatin to ezetimibe resulted in pain improvement, but also in plasma lipids increase beyond the normal range. Ezetimibe was switched to rosuvastatin+ analgesic; in the meanwhile a high-performance liquid chromatography (HPLC) analysis showed low levels of 25-hydroxy-vitamin D and 1-25-dihydroxy-vitamin D. Therefore, vitamin D3 was added to rosuvastatin, resulting in pain improvement, decrease of plasma lipids and progressive discontinuation of analgesics. During the follow-up, rosuvastatin was switched to atorvastatin + vitamin D3, with a good control of plasma lipid levels and without the onset of myalgia.
The evolution of the histopathologic classification of thymic epithelial tumors

Few topics in pathology have been as controversial as the classification of thymic epithelial tumors (TET). The lack of knowledge regarding the structure and function of the thymus has certainly contributed to this difficulty. Only in the second part of the 20 th century did a new awareness concerning the importance of the thymus emerge. Moreover, the heterogeneity of the histopathologic features and the variability of the lymphocytic content in TET contributed to an increase in the number of histologic classifications. This review covers the main classifications and points out the people who developed several classification schema and their underlying “driving” concepts. Historically, the first step regarded the need to separate TET from other tumors occurring in the mediastinum. Subsequently the discussion focused on establishing TET types or subtypes with different prognostic value. The development of histopathologic classifications of TET took also advantage of progressing advances in the knowledge of the thymus together with the adoption of new diagnostic tools which increased diagnostic accuracy and reproducibility. The ultimate goal of the diagnostic pathological process, from the very beginning, was to provide the most useful information to the clinicians (thoracic surgeons, oncologists) involved in patient management.
Principal Components Estimation and Identication of the Factors

It is known that the principal component estimates of the factors and the loadings are rotations of the underlying latent factors and loadings. We study conditions under which the latent factors can be estimated asymptotically without rotation. We derive the limiting distributions for the factor estimates when N and T are large and make precise how identification of the factors affects inference based on factor augmented regressions. We also consider factor models with additive individual and time effects.
The Moderating Influence of Broad‐Scope Trust on Customer–Seller Relationships

Trust relates not only to customer trust in individual companies (i.e., narrow-scope trust) but also to the broader business context in which customer–seller relationships may develop (i.e., broad-scope trust [BST]). Based on two surveys comprising 1155 bank consumers and 817 insurance consumers, respectively, this study investigates the moderating influence of BST on relationships between satisfaction, narrow-scope trust, and loyalty and also examines the direct influence of BST on these variables. The results indicate that whereas BST negatively moderates relationships between satisfaction and narrow-scope trust and between narrow-scope trust and loyalty, BST positively moderates the relationship between satisfaction and loyalty. In addition, it is demonstrated that BST positively influences customer satisfaction and narrow-scope trust. © 2012 Wiley Periodicals, Inc.
Studies on the Antioxidant and Antimicrobial Properties of Rosemary (Rosemarinus ofﬁcinalis) and Oregano (Origanum vulgare) Extracts

Phenolic compounds are commonly found in both edible and non-edible plants and they have been reported to contain multiple biological effects, including antioxidant and antimicrobial activity. The interest towards the utilization of crude extracts of herbs and other plant materials rich in phenolics increased in the food industry because they retard oxidative degradation of lipids thereby improving the quality and nutritional value of food. The importance of the antioxidant constituents of plant materials in the maintenance of health and protection from coronary heart disease and cancer is also raising interest among scientists, food manufacturers, and consumers as the trend of International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 6 Number 12 (2017) pp. 3253-3261 Journal homepage: http://www.ijcmas. com
Birmingham Business School Discussion Paper Series Bureaucrats or Politicians ? Political Parties and Antidumping in the US Tommaso Aquilante 2016-05

Antidumping (AD) is the most widely used contingent protection measure. In the United States, key decisions on AD are delegated to the International Trade Commission (ITC), an independent agency composed of six non-elected commissioners. Using a newly collected dataset, I study the determinants of all final ITC votes on AD during the 1980-2010 period. Contrary to the view that ITC commissioners are bureaucrats who simply follow technical rules, I find that their decisions crucially depend on which party has appointed them (the selection effect) and on the trade policy interests of key senators in that party (the pressure effect): whether (Democratic) Republican-appointed commissioners vote in favor of AD depends crucially on whether the petitioning industry is key (in terms of employment) in the states represented by leading (Democratic) Republican senators.
Macular pigment optical density and academic achievement among preadolescent children

Lutein has been shown to preferentially accumulate in the macula of the neural retina as macular pigment and across all brain cortices of infants and adults. This preferential accumulation in the brain has led to the hypothesis that lutein may positively impact cognition, possibly through its anti-inflammatory and/or antioxidant properties. Both macular pigment optical density (MPOD) – a non-invasive measure of retinal lutein and correlate of brain lutein – and dietary lutein supplementation have been associated with better cognitive function among adult populations. However, the reliability of heterochromatic flicker photometry (HFP) to measure MPOD has only recently been demonstrated to be a moderately reliable technique in preadolescent children. Therefore, to date, the relationship between MPOD and cognitive performance has not been directly investigated in children. Accordingly, the main objective of this thesis was to investigate the relationship between MPOD, assessed and averaged over two time points using HFP, and academic performance among 8-10-year-olds (N = 56). Additional objectives were to investigate how MPOD relates with dietary intake of lutein and zeaxanthin, and to determine if lutein and zeaxanthin intake would mediate the relationship between MPOD and academic performance. Academic performance was assessed using the Kaufman Test of Academic and Educational Achievement II (KTEA). Habitual dietary intake of lutein and zeaxanthin was measured using the average of 3-day food records. The results for the main objective of this thesis indicated a significant correlation between MPOD and the KTEA composite measures of achievement (r = 0.40, P < 0.01), reading (r = 0.28, P = 0.04), math (r = 0.35, P < 0.01), and written language (r = 0.41, P < 0.01), but not with reading fluency (r = 0.22, P = 0.11). Further analysis with stepwise hierarchical regression models was conducted with sex, intelligence quotient (IQ), whole body percent fat, and fat free mass VO2max included in the
Exploring the ‘how’ and ‘why’ of Value Orientations in Physical Education Teacher Education

This paper focuses on the significance of curriculum value orientations for curriculum implementation and, therefore, for teacher education. The paper draws on data arising from research undertaken with six Health and Physical Education teachers in Aotearoa New Zealand to explore issues pertinent to Physical Education teacher education (PETE). Selected findings from the study are presented and critically engaged with from a teacher education viewpoint to specifically address (i) considerations relating to students’ value orientations that teacher educators need to be cognisant of, and (ii) issues arising for teacher educators seeking to engage with value orientations in undergraduate and/or post-graduate PETE programmes. The paper foregrounds the highly personal nature of value orientations in considering their significance in teacher education programmes and is written from the position of the author as a teacher educator committed to raising student teachers’ awareness of value orientations and their influence on curriculum and pedagogy. Attention is drawn to the significance of course content, practicum, critically reflective practice, and programme structures in relation to efforts to embed value orientations into teacher education programmes.
The Early Language in Victoria Study (ELVS): A prospective, longitudinal study of communication skills and expressive vocabulary development at 8, 12 and 24 months

The aim of this paper is to provide an overview of the methods and preliminary findings from the Early Language In Victoria Study (ELVS) a prospective, longitudinal study of child language impairment. Specifically, we provide a summary of early communication and vocabulary development and examine the contributions a range of risk factors and predictors make to these outcomes. The sample was a community-ascertained cohort of 1911 infants, recruited at 8 months and followed at ages 12 and 24 months. The main outcomes of interest were parent reported infant and toddler communication (Communication and Symbolic Behavior Scales, CSBS) and expressive vocabulary (MacArthur-Bates Communicative Development Inventories, CDI). Predictors included gender, preterm birth, birth weight, multiple birth, birth order, socioeconomic status, maternal mental health, maternal vocabulary and education, maternal age at birth of child, non–English-speaking background, and a family history of speech and/or language difficulties. Results demonstrated rapid development in communication skills measured by the three CSBS domains (social, speech and symbolic) and in vocabulary development (CDI). There was rapid growth in gesture use between 8 and 12 months and symbolic use of objects between 12 to 24 months. At approximately 24 months, 19.7% had delayed expressive vocabulary. Male gender and family history were associated with poorer outcomes on the CSBS and the CDI at 8, 12 and 24 months, although the regression models explained only a small amount of the variance in outcome. In summary we measured rapid growth in communication skills and vocabulary between 12 and 24 months, but the hypothesized early risk factors and predictors explained little of the variation in these outcomes. We conclude that the risk factors/predictors examined in this study therefore seem unlikely to be helpful in screening for early language delay.
Trypanocidal activity of coumarins and styryl-2-pyrones from Polygala sabulosa A.W. Bennett (Polygalaceae)

Bioactivity of fractions and compounds obtained from Polygala sabulosa against Trypanosoma cruzi epimastigote, blood trypomastigote and amastigote forms were evaluated in vitro. Dichloromethane and ethyl acetate fractions showed a strong trypanocidal activity on epimastigotes (IC50 < 10.4 µg/mL). Chromatographic analysis by TLC of these fractions confirmed the presence of previously described compounds (dihydrostyryl-2-pyrones, styryl-2-pyrones and 6-methoxy-7-prenyloxycoumarin). The dichloromethane fraction was fractioned by silica gel column chromatography to afford the compound α-spinasterol and the ethyl acetate fraction yielded apigenin, quercetin and a quercetin-3-O-glucoside, being the first description for the Polygala genus. 4-Methoxy-6-(11,12-methylenedioxy-14-methoxydihydrostyryl)-2-pyrone, 4-methoxy-6-(11,12-dimethoxystyryl)-2-pyrone, 6-methoxy-7-prenyloxycoumarin and quercetin-3-O-glucoside showed a weak activity against blood trypomastigotes (IC50 < 1008.6 µg/mL). The prenylated coumarin was the most active compound against both epimastigote and trypomastigote forms, IC50 10.5 and 88.2 µg/mL, respectively. The hemolytic activity and cell toxicity of each active compound was also assessed. Furthermore, 4-methoxy-6-(11,12-methylenedioxy-14-methoxydihydrostyryl)-2-pyrone and 6-methoxy-7-prenyloxycoumarin reduced 4 times the T. cruzi infection rate for Vero cells at 100 and 50 µg/mL, respectively. These results show for the first time active compounds against T. cruzi in P. sabulosa.
Morbidity profile of infants of mothers with gestational diabetes admitted to a tertiary care centre

Background: Infants born to mothers with gestational diabetes are at increased risk of neonatal morbidities like birth trauma, hyperbilirubinemia, hypoglycemia, birth asphyxia etc., Maternal glycemic control has been one of the parameters that determines the occurrence of these problems. Methods: A retrospective study done by analysing the case records of babies born to mothers with gestational diabetes and admitted to the NICU of Govt Kilpauk Medical college from January 2015 to December 2015. The morbidity profile of infants born to mothers with gestational diabetes was analysed and comparison was made between the two groups namely mothers who were managed by meal plan and those who were managed by insulin. Results: About 198 babies were analysed majority were delivered by caesarean section (83%). Only 2 babies (1%) weighed more than 4000gms. The commonest morbidity observed was hyperbilirubinemia (24.2%) which was 27.7% in the insulin group as against 19% in the group on meal plan. The next common morbidity was sepsis (15.2%). This was also common in insulin group 18.5% as against 10.1% in the meal group. Others were hypoglycemia (4%), congenital heart disease (2.5 %) and respiratory distress syndrome (1.5 %). Conclusions: Babies born to mothers with gestational diabetes were found to have morbidities like hyperbilirubinemia and sepsis. Less commonly found morbidities were hypoglycemia, birth asphyxia, respiratory distress syndrome etc., Though the morbidities were more common among insulin group as compared to the group on meal plan this difference was not statistically significant.
Effect of Hydroalcoholic Extract of Chevil (Ferulago angulata) on Glucose and Lipid in Diabetic Male Rats

Introduction: Diabetes is a metabolic disease characterised by chronic hyperglycemia. Considering the properties antioxidant of the Chevil plant compounds, this study performed to determine the effect of hydroalcoholic extract of Chevil on serum glucose and lipid in diabetic male rats. Materials and Methods: In this study, 54 male Wistar rats weighing 200-250 g were divided into 6 groups (n=9 each) and studied for 4 weeks. The groups were as follows: Control, diabetic, diabetic groups treated 200, 400 and 800 mg/kg body weight of the Chevil extract, respectively and the diabetic rats treated with 150 mg/kg body weight of metformin. At the end of study, FBS, Cholesterol, Triglycerides, HDL-C, and LDL-C levels were measured. Results were analyzed by one-way ANOVA. Results: Findings showed a significant reduction (P<0.05) of FBS in all groups with three doses of the extract, 26%, 59.3%, 69.4% respectively), Triglycerides (at 200 and 400 mg/kg of the extract respectively 16.1% and 34.1%), Cholesterol (800 mg/kg of the extract, 20.9%), LDL-C in all three doses of the extract, 25.9%, 49.1% and 53% respectively and a significant increase (P<0.05) in HDL-C in all three doses of the extract, 32.6%, 36.4% and 37.1% respectively compared to the control group was observed in diabetic rats treated with Chevil. Conclusion: The results of this study showed that Chevil extract reduces blood sugar and improves blood lipid profiles in diabetic rats.
The negative effects of failed service recoveries

Research has shown that more than half of attempted recovery efforts fail, producing a "double deviation" effect. Surprisingly, these double deviation effects have received little attention in marketing literature. This paper examines what happens after these critical encounters, which behavior or set of behaviors the customers are prone to follow and how customers' perceptions of the firm's recovery efforts influence these behaviors. For the analysis of choice of the type of response (complaining, exit, complaining and exit, and no-switching), we estimate multinomial Logit models with random coefficients (RCL). The results of our study show that magnitude of service failure, explanations, apologies, perceived justice, angry and frustration felt by the customer, and satisfaction with service recovery have a significant effect on customers' choice of the type of response. Implications from the findings are offered. La investigacion ha mostrado que mas de la mitad de los intentos de recuperacion tras el fallo de un servicio fracasan, lo que produce un efecto de "desviacion doble". Sorprendentemente, estos efectos de desviacion doble han recibido muy poca atencion en la literatura de marketing. Este trabajo analiza que ocurre tras estos encuentros criticos, ? que comportamiento o conjunto de comportamientos tienden a seguir lo clientes? y ? como afectan a estos comportamientos las percepciones de los clientes acerca del problema y de los esfuerzos de recuperacion de la empresa? Para el analisis del tipo de respuesta (queja, abandono, queja y abandono, y no cambiar de entidad), estimamos modelos Logit multinomiales con coeficientes aleatorios (RCL). Los resultados de nuestro estudio muestran que la magnitud del fallo inicial, las explicaciones y disculpas recibidas tras el mismo, la justicia percibida en la gestion de la queja, la frustracion y el enfado que siente el cliente y la satisfaccion con el proceso de recuperacion, tienen un efecto significativo en la eleccion de los clientes del tipo de respuesta de queja. Finalmente, se ofrecen implicaciones para la gestion.
Knowledge, attitude and practices of peasants towards hyraxes in two selected church forests in Tigray Region, Northern Ethiopia

Church forests comprise local as well as global hotspots as critical conservation areas for a large portion of Ethiopian biodiversity. This study was conducted in two selected church forests based on presence of hyrax species and forest coverage in Tigray region, Northern Ethiopia to assess knowledge, attitude and practice (KAP) of peasants towards hyraxes in the church forests. Data collection was carried out from August, 2012 to January, 2013 using questionnaires’ which contains both open and closed ended questions. The knowledge, attitude and practice of the local people towards the hyraxes and church forests were varied among the two church forests. Most respondents from Michael Tsilwo church forest had negative attitude towards the hyrax species although most respondents from Michael Romanat had positive attitude. The church forests have great contribution as habitat and source of food for the hyraxes in particular and many wild animals in general. Most of the local people living around the church forests do not seem to understand the ecological roles of the hyraxes and wildlife. Therefore, awareness creation programmes should be organized to the community and it will help to develop positive attitude towards hyraxes.
Choice of Foreign R&D Entry Mode and Its Relation to Firm Performance: A Firm-level Analysis for Switzerland and Austria

Abstract The objective of this study is to identify the determinants of a firm’s foreign entry mode choice and the relationship between mode selection and firm performance for the specific case of R&D—a topic not yet investigated in entry mode research. Separate estimates of a Heckman selection model for Austria and Switzerland based on comparable firm-level data and variable specification show for both countries that the OLI model is well-suited to explain not only the propensity to invest in R&D abroad but also the related choice between an equity-based and a non-equity governance mode. Moreover, the research reveals that foreign R&D activity is positively related to firm performance and that this relationship is stronger in the case of an equity-based mode of governance, however only in the Swiss case. The differences between the two countries primarily reflect the much higher degree of internationalisation of the Swiss economy. Data available upon request (see the following link): http://www.economics-ejournal.org/economics/journalarticles/2015-34/dataavailability-2015-34/view
The Placebo Effect in Marketing: the Ability of Country of Origin to Modify Product Performance

The placebo effect was first noted in studies in the areas of clinical medicine and pharmacology, and basically consists of the ability of inert products to produce effects because of the userâ€™s belief in their efficacy. Stereotypes due to the country of origin of products is a global phenomenon, in which goods from countries with negative stereotypes are perceived as having worse quality in relation to products from countries with positive reputations. This study analyzed the occurrence of this effect for an energy drink, based on an experiment among 105 university students, by measuring the variations in mental acuity and reasoning speed after drinking products supposedly originating from different countries. The results indicated that the origin from a country with a negative stereotype regarding product quality can generate a negative placebo effect. In other words, the subjects who drank the beverage thinking it was from China performed worse that the participants of the control group, who thought the drink came from Germany. However, we did not identify a positive placebo affect of that country of origin. Classification-JEL:
High Hydrostatic Pressure Effects on Color and Milk‐Fat Globule of Ewe's Milk

The influence of high hydrostatic pressure treatments on lipolysis, color, and size distribution of milk fat globule (MFG) on ewe's milk was studied. Treatments consisted of combinations of pressure (100 to 500 MPa) and temperature (4, 25, and 50 °C) for 10 min. Pressurized samples showed FFA levels lower than control. Pressurizations at 25 and 50 °C showed a tendency to increase MFG in the range 1-2 μm and to decrease MFG between the range 2 to 10 μm, whereas at 4 °C the effect was the reverse. A decrease of lightness (L * ) value, and an increase of (-a * ) and (+b * ) values occurred in coior with pressure increase. Le procede des hautes pressions peut inactiver les microorganismes sans alterer les constituants alimentaires, le gout et la flaveur du produit. Il empeche aussi l'inactivation des enzymes, importantes dans la maturation du fromage. Dans le lait frais entier, les lipides se trouvent sous forme de globules gras disperses et sont entoures d'une membrane native qui previent la floculation et la coalescence des globules gras et les protege aussi de l'action enzymatique de la lipase. Pendant les traitements laitiers, mecaniques et thermiques, cette membrane est alteree. L'objet de cette etude est d'evaluer les effets sur quelques proprietes physicochimiques (lipolyse, taille et distribution des globules gras, couleur) du lait de brebis du traitement par une combinaison de pression (100 a 500 MPa) et de temperature (4, 25 et 50°C).