Miracle-dz/UniFAR-FTUs huggingface dataset:
Psychopathy and physiological responses to threat of an aversive stimulus.

Physiological activity was monitored while 64 prison inmates awaited delivery of a 120dB tone during a 12-sec “count-down” procedure. The inmates were divided into four groups on the basis of global ratings of psychopathy (interrater reliability = .86) and scores on the Socialization (So) scale. Twelve inmates in the group considered to be most psychopathic (high ratings of psychopathy and low So scores) showed larger increases in heart rate and smaller increases in electrodermal activity in anticipation of the tone than did 20 inmates in the group considered to be least psychopathic (low ratings of psychopathy and high So scores). These findings were consistent with those of several previous studies, and were interpreted as a reflection of an association between psychopathy and the operation of efficient mechanisms for coping with threat.
EPIDEMIOLOGY OF TYPE 1 DIABETES IN CHILDREN IN HUNGARY PhD Thesis

S IN RELATION TO THESIS 1. EK Gyurus, G. Soltesz & The Hungarian Childhood Diabetes Epidemiology Group: Changing pattern in incidence of type 1 diabetes in Hungarian children over 1989– 2008. Pediatric Diabetes 2010; 11:(Suppl. 14), O3, page 23. IF:2.171 2. E Gyurus, G. Soltesz for the Hungarian Childhood Diabetes Epidemiology Study Group: Clinical characteristics at presentation – analysis of 1444 prospective incidence cases of the Hungarian Registry (2002-2008) Pediatric Diabetes 2009; 10:(Suppl. 11), Inv 38, p 12 IF:2.628 3. Gyürüs E, Györkő M, Patterson C, Green A, Soltész G and the Hungarian Childhood Diabetes Epidemiology Group. Twenty year incidence of type 1 diabetes in Hungarian children (1978-1997). Diab Res and Clin Practice 1999; 44:(Suppl. 81)
Energy Balance Estimated from Individual Measurements of Body Weight and Backfat Thickness of Heavy Pigs of Four Genetic Lines Fed Different Diets

Summary Pigs of four genetic lines (GL): Anas (A), DanBred (D), Goland (G) and Topigs received either a conventional (140 g CP/kg and 46 g lysine/kg CP; C-CP) or a low protein diet (106 g CP/kg and 46 g lysine/kg CP; L-CP). Body weight (BW) and backfat depth (P2) were individually measured at the start and the end of two growing periods and individual feed intake (FI) was recorded daily. Body protein and lipid mass at the start and at the end of each period were estimated from BW and P2, and hence protein (Pr) and lipid (Lr) retention were computed. Energy requirement for maintenance (MEm), and growth (MEg) were estimated according to National Research Council guidelines, while ME intake (MEI) was computed from measured FI and ME content of the diets. Th e MEI/(MEm + MEg) ratio was used as index of effi ciency. Diff erences among GL (P<0.001) were observed for Pr, which averaged 103, 113, 108 and 101 g/d for A, D, G and T, respectively, and Lr which averaged 204, 186, 194 and 172 g/d for A, D, G, and T, respectively. Th e L-CP diet reduced (P = 0.014) Pr by 8% compared to C-CP, but not Lr. Th e MEI/(MEm+MEg) index was infl uenced by GL (P<0.001) being 0.99, 0.96, 0.99 and 1.03 for A, D, G and T, respectively. Measurements of BW and P2 permits to achieve acceptable quantifi cation of Pr and Lr. In this range of BW (90 to 165kg), gain composition is infl uenced more by GL than by the substantial reduction of CP and essential amino acids dietary density used in this trial.
Differences in neurocognitive functioning associated with alcohol consumption in a multiethnic rural cohort: A Project FRONTIER study

ABSTRACT The current study assessed if a neuroprotective effect on cognition from mild alcohol consumption occurs in multiethnic rural communities and if effect differences occur due to gender or ethnicity. Participants were drawn from Project FRONTIER (Facing Rural Obstacles to healthcare Now Through Intervention, Education & Research), a community-based participatory research study assessing aging in a rural, West Texas, multiethnic cohort of participants aged 40 years and older. Alcohol consumption patterns were determined from Alcohol Use Disorders Identification Test responses. Cognitive measures included the Repeatable Battery for the Assessment of Neuropsychological Status. Because few participants had greater than a mild alcohol consumption pattern, only abstinent participants and those with mild consumption were compared (N = 1,004 1st observation; N = 256 2nd observation). Multivariate analysis of covariance revealed main effects for alcohol consumption pattern, gender, and ethnicity. Attention was most affected by alcohol consumption pattern followed by verbal memory. Mild alcohol consumption was associated with better performance in these areas. Gender and ethnicity had broad effects on cognitive abilities but inconsistent attention effects. Overall, mild alcohol consumption was associated with better attentional and other abilities compared with abstinence in a rural multiethnic sample. These findings are consistent with previous research and suggest ethnicity and gender are uninvolved in any alcohol neuroprotective effects.
State of oxidation-reduction and state of binding in the cytosolic NADH-system as disclosed by equilibration with extracellular lactate-pyruvate in hemoglobin-free perfused rat liver.

1 The extracellular ratio [lactate]/[pyruvate] is used as a means to poise the cytosolic NADH/NAD+ system. This is achieved by stepwise changes of [lactate]/[pyruvate] in the perfusate in an open system. Fluorescence and absorbance at NADH-specific wavelengths is recorded simultaneously with single or dual wavelength methods. Fluorescence excitation and absorbance difference spectra are obtained with the help of an instrument computer. The readout is calibrated by infusion of internal standards, permitting an estimation of the enhancement of quantum yield of NADH-specific fluorescence. 2 Mathematical treatment on the basis of the mass action law permits extrapolation to fully reduced and fully oxidized cytosolic bound NADH. In addition, the apparent equilibrium constant for bound NADH/NAD+ and lactate/pyruvate is obtained (0.022 to 0.071), corresponding to a midpoint potential of bound NADH of – 250 to – 265 mV. Accordingly, the ratio of dissociation constants, KNAD+/KNADH, relevant for the cytosolic binding sites, is 200–700. Cytosolic NADH-binding capacity is estimated to be around 80 nmol/g liver wet weight. Under normoxic conditions at [lactate]/[pyruvate] of 10 in the perfusate, the ratio of contents of cytosolic bound NADH/free NADH is 100. 3 The existence of near-equilibrium conditions in the system is suggested by measurement of net H+ transport coupled to lactate import, as well as by determination of an intracellular dependent indicator metabolite couple, α-glycerophosphate/dihydroxyacetone phosphate. Problems regarding the validity of tissue contents of lactate/pyruvate as indicator for the cytosolic NADH/NAD+ potential are discussed.
Work-Related Well-Being of Emergency Workers in Gauteng

The objective of this study was to assess the relationships between occupational stress, sense of coherence, burnout and work engagement of emergency workers in Gauteng and to determine whether sense of coherence moderates the effects of occupational stress on burnout and work engagement. A cross-sectional survey design was used. A convenience sample (N = 323) was taken from emergency workers in Gauteng. The Maslach Burnout Inventory — Human Services Survey, the Utrecht Work Engagement Scale, the Emergency Worker Stress Inventory and the Orientation to Life Questionnaire were administered. The results showed that occupational stress (as a result of a lack of job resources) and a weak sense of coherence predicted emotional exhaustion and depersonalisation. Sense of coherence predicted personal accomplishment and work engagement. However, sense of coherence did not moderate the effects of occupational stress on emotional exhaustion, depersonalisation, personal accomplishment or work engagement.
[Effects of cigarette smoke on phagocytosed function of monocyte-derived macrophage in chronic obstructive pulmonary disease patients].

OBJECTIVE To explore the effects of cigarette smoke extract (CSE) on phagocytosizing function of monocyte-derived macrophages (MDMs) in patients with chronic obstructive pulmonary disease (COPD). METHODS From January 2012 to March 2013, peripheral blood monocytes were isolated from 32 stable COPD patients and 32 healthy controls at First Hospital, Lanzhou University. MDM was induced and cultured from monocytes in vitro. The MDMs from COPD patients and healthy controls were divided into 4 groups of COPD non-CSE (conventional culture), COPD CSE (4% CSE treatment for 6 h), healthy non-CSE (conventional culture) and healthy CSE (4% CSE treatment for 6 h). Flow cytometry (mean fluorescence intensity, MFI) and laser scanning confocal microscopy (fluorescence grey level) were applied to detect the ability of MDM phagocytosed fluorescein-labeled Escherichia coli (FITC-E.coli). Total antioxidative capacity (TAC) was measured by o-phenanthroline colorimetry. Malondialdehyde (MDA) was measured by thiobarbituric acid colorimetry and glutathione peroxidase (GSH-PX) by 5, 5'-dithiobis-2-nitrobenzoic acid (DTNB) method. RESULTS MFI and fluorescence grey level in COPD non-CSE group (20.2 ± 2.2, 51.5 ± 5.8) significantly decreased than those in healthy non-CSE group (56.9 ± 6.7, 87.3 ± 7.3). And in COPD CSE (7.6 ± 0.7, 14.1 ± 3.4) and healthy CSE groups (48.0 ± 5.4, 69.7 ± 6.0) decreased more than those in COPD non-CSE and healthy non-CSE groups (all P < 0.01). The levels of TAC and GSH-PX in COPD non-CSE group ((4.1 ± 0.5), (47.1 ± 4.1) U/ml) were lower than those in healthy non-CSE group ((5.1 ± 0.6), (88.4 ± 2.3) U/ml). And in COPD CSE and healthy CSE groups ((3.1 ± 0.4), (26.8 ± 6.2) U/ml) and (4.5 ± 0.4), (72.3 ± 5.1) U/ml) were respectively lower than those in COPD non-CSE and healthy non-CSE groups (all P < 0.01). The content of MDA in COPD non-CSE group was higher than that in healthy non-CSE group [(4.8 ± 0.5) vs (2.1 ± 0.4) µmol/L)]. And in COPD CSE and healthy CSE groups ((7.7 ± 0.9), (3.0 ± 0.6)µmol/L) were higher than those in COPD non-CSE and healthy non-CSE groups (all P < 0.01). At basic status, positive correlations existed between MFI and TAC, GSH-PX (r = 0.523, 0.818, P = 0.038, 0.001) while negative correlations between MFI and MDA (r = -0.501, P = 0.048) in COPD patients and after CSE treatment, the above relationships still existed (r = 0.704, 0.716, -0.522, P = 0.002, 0.002, 0.038). CONCLUSIONS Cigarette smoke can reduce the phagocytosizing ability of MDM in COPD patients. And it may be related with oxidative stress.
Diet, nutrition and the ageing brain: current evidence and new directions

Globally populations are ageing. By 2050, it is estimated that there will be two billion people aged 60 years or over, of which 131 million are projected to be affected by dementia, while depression is predicted to be the second leading cause of disability worldwide by 2020. Preventing or delaying the onset of these disorders should therefore be a public health priority. There is some evidence linking certain dietary patterns, particularly the Mediterranean diet, with a reduced risk of dementia and depression. Specific dietary components have also been investigated in relation to brain health, with emerging evidence supporting protective roles for n-3 PUFA, polyphenols, vitamin D and B-vitamins. At this time, the totality of evidence is strongest in support of a role for folate and the metabolically related B-vitamins (vitamin B12, vitamin B6 and riboflavin) in slowing the progression of cognitive decline and possibly reducing the risk of depression in ageing. Future studies incorporating new technologies, such as MRI and magnetoencephalography, offer much promise in identifying effective nutrition interventions that could reduce the risk of cognitive and mental disorders. This review will explore the ageing brain and the emerging evidence linking diet and specific nutrients with cognitive function and depression in ageing, with the potential to develop strategies that could improve quality of life in our ageing population.
Efficiency of the mixed biocide GCSC-BtA against vegetable pests of different arthropod orders in the south-eastern China

The present paper deals with the efficiency of the mixed biocide GCSC-BtA against vegetable pests of five orders of arthropod insects in the south-eastern China, i. e. , diamondback moth, Plutella xylostella (L.); green peach aphid, Myzus persicae (Sulzer); yellow-fanded flea beetle, Phyllotreta vittata Fabricius; vegetable leaf miner, Phytomyza nigricornis Macquart; and vegetable spider mite, Tetranychus neocaledonicus Andre. The results show that the mixed biocide GCSC-BtA has a higher efficacy of control against all of the five pests than the commercial biocide B.t. and insecticide Diazinon. GCSC-BtA gave a higher mortality value of 92.18 % against P. xylostella as compared to the biocide B.t. with a value of 64.70 % and Diazinon with a value of 50.00 %. Similar mortalities were obtained with the other four pests regarding the efficacy of the three products tested against them.The concentration-mortality regression equations were calculated by the probit analysis, from which the average mortalities were calculated. The values calculated for GCSC-BtA were 81.13 % for P. xylostella, 75 % for M. persicae and T. neocaledonicus, 69.23 % for P. vittata, and 61.03 % for P. nigricornis as compared to those caused by Diazinon: 33.33 %, 27.42 %, 66.31 %, 44.54 %, 19.65 % for P. xylostella, M. persicae, P. vittata, P. nigricornis, and T. neocaledonicus, respectively. Based on LC50, P. xylostella was most susceptible to GCSC-BtA with a LC50 value of 0.3445, followed by B.t. with a value of 0.8404 and Diazinon with a value of 1.3160. The LC50 value of GCSC-BtA for M. persicae was 0.4660 which was about three times less than that of Diazinon. LC50 value of GCSC-BtA for P. vittata was 0.3954 which was about the same as that of Diazinon. P. nigricornis and T. neocaledonicus were also much more susceptible to GCSC-BtA than to B.t. and Diazinon. It is concluded that GCSC-BtA kills more target pests than B.t. and is more effective than Diazinon in controlling the vegetable pests.
From Cuthbertson to Fast-Track Surgery: 70 Years of Progress in Reducing Stress in Surgical Patients

ObjectiveTo evaluate the evolution of knowledge concerning the stress response in surgical patients and to determine the therapeutic benefit of stress reduction therapy. Summary Background DataThe stress response in surgical patients is associated with tissue catabolism, organ failure, and prolonged recovery. Understanding the neural-hormonal basis for these events has stimulated efforts to attenuate these undesirable effects. A review of the results of these efforts is important for the application of stress reduction therapy and further improvement of surgical care. MethodsMedline was searched from 1980 to the present using the terms “stress response,” “neural-hormonal response,” “fast track surgery,” and “outcome in surgical patients. ” These papers were reviewed along with historical information relating to early descriptions of metabolic and stress responses in surgical patients. ResultsImproved understanding of the stress response in surgical patients has occurred over the past 70 years. Multiple examples of stress reduction associated with decreased morbidity and mortality are reported. ConclusionsReduction of stress in surgical patients has improved outcome. The use of stress reduction techniques will continue to expand and contribute to the improvement of future surgical care.
Adequate synapse formation between leukemic B cells and effector T cells following stimulation with artificial TCR ligands

Artificial T cell receptor (TCR) ligands can be used to direct virus-specific cytotoxic T lymphocytes (CTL) towards tumor cells. Because of their size, these constructs may differ from cognate peptides in their ability to induce T cell activation. We here analysed signalling outcomes upon synapse formation between human cytomegalovirus (CMV)-specific CTL and chronic lymphocytic leukemia (CLL) cells through targeted complexes (TC) containing anti-CD20 single-chain variable fragment and biotinylated major histocompatibility complex class I molecules presenting peptides from CMVpp65. TC coated CLL cells were effectively lysed by CMVpp65-specific CTL but induced less interferon gamma (IFN-γ) production than peptide loaded targets. Confocal microscopy revealed that TC induced a redistribution of TCR/CD3 but not CD2 towards the immunological synapse. Furthermore, morphological examination of immunological synapses showed smaller and ‘patchy’ interactions between TC coated B cells and CTL as compared with peptide coated targets. Finally, pre-incubation of CTL with CD2 antibodies led to an Fc-dependent redistribution of CD2 into TC-induced synapses and restored IFN-γ production by CMV-specific CTL. Thus, redistribution of CD2 towards the immunological synapse appears to be essential for full T cell activation. However, CD2 triggering is not required for efficient lysis of tumor cells, demonstrating that CTL require only minimal stimulation to release their cytotoxic content.
The Fajada Butte Solar Marker: A Reevaluation

Evaluation of the Fajada Butte solar marker in Chaco Canyon, New Mexico, on the basis of its ethnographic context and usefulness for confirmatory and anticipatory solar observations indicates that the site does not function as an accurate solar calendar (accurate in the context of the historic Puebloan culture). The site most likely served as a sun shrine rather than as a calendrical observing station. The interpretation of the site as marking the northern declinations of the lunar 18.6-year cycle is not supported by the ethnographic evidence nor can the site be used to anticipate accurately the year of the standstill.
Correlations of Physical Activity, Body Mass Index, Shift Duty, and Selected Eating Habits among Nurses in Riyadh, Saudi Arabia

Nurses are the largest group of direct health providers and can serve as role models for their patients. In this cross sectional study we assessed the relationship among physical activity and barriers, shift duty, elevated BMI, and selected eating habits among 362 non-Saudi female nurses in Riyadh, Saudi Arabia. Results showed that 46.7% were either overweight or obese. Marital status, shift duty, education level, and BMI were significant predictors of physical activity. Weather was the most frequently reported barrier to physical activity (88.3%), followed by a lack of transportation (82.6%), and a lack of time (81.3%). Nurses who worked shift duty had significantly (p = 0.004) higher BMIs compared with day shift nurses. Nurses who rarely ate breakfast (p = 0.004) and meals (p = 0.001) and often eat fast food (p = 0.001) were more likely to be overweight or obese. Nurses should be encouraged for a better healthy lifestyles.
The spectrum of renal lesions in patients with cirrhosis: a clinicopathological study

Background/objective: Little is known on the morphological changes in the kidneys of cirrhotic patients with abnormal urinalysis and/or high serum creatinine levels. This retrospective, one‐point‐in‐time study aimed to report the results of the analysis of renal biopsy specimens obtained in patients with cirrhosis.
Neuroendocrine cells in serially passaged rat stomach cancers induced by MNNG

Five gastric carcinomas, induced in inbred Wistar rats by oral administration of N‐methyl‐N'‐nitro‐N‐nitrosoguanidine (MNNG) dissolved in drinking water, were successfully transplanted to isologous rats. The transplants grew to a size of 10 to 35 mm in diameter within 8 to 25 weeks of implantation. In one case, serial transplantations were maintained up to the 11th generation, with occurrence of distant metastasis in the 3rd generation. Histological, histochemical, and electron microscopical comparison of the original and transplanted tumors revealed thet (1) the original tumors were quite well differentiated, forming either papillary or tubular structures, whereas the transplants were more anaplastic and pleomorphic showing often solid nests; and (2) tumor cells with gastrointestinal differentiation and cells with neuroendocrine differentiation were present and evenly distributed in both the original and the serially transplanted tumors. As it is unlikely that the normal and neo‐plastic neuroendocrine cells are growing side‐by‐side with and independently of the epithelial neoplastic components in the present series of transplants, the findings strongly suggest (1) the multidirectional potency of the inbred rat stomach carcinoma cells and (2) the common neoplastic origin of the epithelial and neuroendocrine components.
Cost-effectiveness of interventions to prevent alcohol-related disease and injury in Australia.

AIMS To evaluate cost-effectiveness of eight interventions for reducing alcohol-attributable harm and determine the optimal intervention mix. METHODS Interventions include volumetric taxation, advertising bans, an increase in minimum legal drinking age, licensing controls on operating hours, brief intervention (with and without general practitioner telemarketing and support), drink driving campaigns, random breath testing and residential treatment for alcohol dependence (with and without naltrexone). Cost-effectiveness is modelled over the life-time of the Australian population in 2003, with all costs and health outcomes evaluated from an Australian health sector perspective. Each intervention is compared with current practice, and the most cost-effective options are then combined to determine the optimal intervention mix. MEASUREMENTS Cost-effectiveness is measured in 2003 Australian dollars per disability adjusted life year averted. FINDINGS Although current alcohol intervention in Australia (random breath testing) is cost-effective, if the current spending of $71 million could be invested in a more cost-effective combination of interventions, more than 10 times the amount of health gain could be achieved. Taken as a package of interventions, all seven preventive interventions would be a cost-effective investment that could lead to substantial improvement in population health; only residential treatment is not cost-effective. CONCLUSIONS Based on current evidence, interventions to reduce harm from alcohol are highly recommended. The potential reduction in costs of treating alcohol-related diseases and injuries mean that substantial improvements in population health can be achieved at a relatively low cost to the health sector.