Miracle-dz/UniFAR-FTUs huggingface dataset:
The Impact of Intensive Community Based Rehabilitation on Community Participation and Life Satisfaction Following Severe Traumatic Brain Injury

Brain injury represents the leading cause of death and disability worldwide (International Brain Injury Association [IBIA], 2011). While a small percentage of traumatic brain injury (TBI) survivors continue in a persistent state of coma, the vast majority return to the community with some residual cognitive, psychosocial, behavioral, or physical impairment (Kersel et al., 2001). These impairments contribute to a dramatic change in the individual’s life course, profound disruption of the family, enormous loss of income or earning potential and large expenses over a lifetime (McKinlay and Watkiss, 2001). The need for effective post-acute rehabilitation for traumatic brain injuries has emerged out of both the limited effectiveness of inpatient models (Department of Health and Human Services [DHHS], 2001) and health care system changes that support reduced average length of inpatient stay (Canadian Institute for Health Information, 2008). Within a traditional inpatient model, interventions generally center around medications, surgery, and therapeutic exercises / activities. While this approach is recognized as a necessary component of TBI treatment, it has been argued that by fostering the ‘patient’ role, the inpatient setting has been inadequate for facilitating improvement in important life roles (Willer, et al., 1992). Roles such as parent, spouse, student, employee, and friend are considered essential to successful and satisfying performance in community settings yet are rarely specifically addressed in traditional brain injury rehabilitation models. Determining what constitutes “successful” rehabilitation following traumatic brain injury has received considerable attention among brain injury clinicians and researchers. Many researchers view community integration as the goal of rehabilitation professionals and the rehabilitation programs (Doig, et al., 2001; McColl, et al., 1998). Successful community integration has been described as settling clients into communities where they are both happy and productive (McColl et al., 1998). Life satisfaction has also been considered an important health indicator and measure of rehabilitation outcome (Department of Health and Human Services [DHHS], 2001).
Transarterial chemoembolization can be safely performed in patients with hepatocellular carcinoma invading the main portal vein and may improve the overall survival.

PURPOSE To determine the efficacy and safety of transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC) and main portal vein (MPV) invasion. MATERIALS AND METHODS This study was approved by the institutional review board, and the requirement to obtain informed consent was waived. The authors retrospectively assessed the electronic medical records of patients in whom HCC with MPV invasion was newly diagnosed from January 2004 to December 2007 at a single tertiary medical center. Patients with decompensated hepatic function were excluded. Outcomes of patients treated with TACE were compared with those of patients given supportive care according to Child-Pugh class. RESULTS One hundred twenty-five patients (104 men and 21 women; mean age, 55.7 years; age range, 33.4-83.0 years) were included. The median overall survival was 3.7 months (range, 0.2-33.3 months). Eighty-three of the 125 patients (66.4%) were treated with TACE and 42 (33.6%) received supportive care. Repeated TACE showed significant survival benefits compared with supportive care in patients with Child-Pugh class A (median survival, 7.4 months vs 2.6 months, respectively; P < .001) and class B (median survival, 2.8 months vs 1.9 months, respectively; P = .002) disease. Results of multivariate analysis showed that treatment with TACE (hazard ratio, 0.263; 95% confidence interval [CI]: 0.164, 0.424; P < .001) and Child-Pugh class A status (hazard ratio, 0.550; 95% CI: 0.368, 0.822; P = .004) were independent predictive factors of a favorable outcome. There were no procedure-related deaths within 4 weeks after TACE, and patient morbidity was 28.9% (24 of 83 patients). CONCLUSION TACE can be performed safely and may improve the overall survival of patients with HCC and MPV invasion.
Knowledge management and organizational performance: an exploratory analysis

– The purpose of this paper is to report the results of an exploratory investigation of the organizational impact of knowledge management (KM). , – A search of the literature revealed 12 KM practices whose performance impact was assessed via a survey of business organizations. , – KM practices were found to be directly related to organizational performance which, in turn, was directly related to financial performance. There was no direct relationship found between KM practices and financial performance. A different set of KM practices was associated with each value discipline (i.e. customer intimacy, product development and operational excellence). A gap exists between the KM practices that firms believe to be important and those that were directly related to organizational performance. , – The majority of the research constructs were formative, thus improving the measurement of KM practices will prove vital for validating and extending these findings. The findings were based solely on organizations from North America and Australia and may not reflect KM practices in other geographic, economic or cultural settings. , – This study encourages practitioners to focus their KM initiatives on specific intermediate performance outcomes. , – The paper examines the relationship between KM practices and performance outcomes. It was expected that a direct relationship between KM practices and organizational performance would be observed. It was also expected that organizational performance would mediate the relationship between KM practices and financial performance. These expectations were supported. KM practices showed a direct relationship with intermediate measures of organizational performance, and organizational performance showed a significant and direct relationship to financial performance. There was no significant relationship found between KM practices and financial performance.
Polycythaemia rubra vera and hairy cell leukaemia in the same patient: studies on the spleen

The first association of polycythaemia rubra vera (PRV) and hairy cell leukaemia (HCL) is reported. The secretion by spleen cells in short term culture of IfGλ to the exclusion κ demonstrated that despite aberrant surface marker studies the HCL was a monoclonal tumour of B cells. Chromosomal studies on splenic cells were not able to demonstrate the common clonal origin of the two tumours.
The dim light melatonin onset following fixed and free sleep schedules

The time at which the dim light melatonin onset (DLMO) occurs can be used to ensure the correct timing of light and/or melatonin administration in order to produce desired circadian phase shifts. Sometimes however, measuring the DLMO is not feasible. Here we determined if the DLMO was best estimated from fixed sleep times (based on habitual sleep times) or free (ad libitum) sleep times. Young healthy sleepers on fixed (n = 60) or free (n = 60) sleep schedules slept at home for 6 days. Sleep times were recorded with sleep logs verified with wrist actigraphy. Half‐hourly saliva samples were then collected during a dim light phase assessment and were later assayed to determine the DLMO. We found that the DLMO was more highly correlated with sleep times in the free sleepers than in the fixed sleepers (DLMO versus wake time, r = 0.70 and r = 0.44, both P < 0.05). The regression equation between wake time and the DLMO in the free sleepers predicted the DLMO in an independent sample of free sleepers (n = 23) to within 1.5 h of the actual DLMO in 96% of cases. These results indicate that the DLMO can be readily estimated in people whose sleep times are minimally affected by work, class and family commitments. Further work is necessary to determine if the DLMO can be accurately estimated in people with greater work and family responsibilities that affect their sleep times, perhaps by using weekend wake times, and if this method will apply to the elderly and patients with circadian rhythm disorders.
Minimal mechanical load and tissue culture conditions preserve native cell phenotype and morphology in tendon—a novel ex vivo mouse explant model

Appropriate mechanical load is essential for tendon homeostasis and optimal tissue function. Due to technical challenges in achieving physiological mechanical loads in experimental tendon model systems, the research community still lacks well‐characterized models of tissue homeostasis and physiological relevance. Toward this urgent goal, we present and characterize a novel ex vivo murine tail tendon explant model. Mouse tail tendon fascicles were extracted and cultured for 6 days in a load‐deprived environment or in a custom‐designed bioreactor applying low magnitude mechanical load (intermittent cycles to 1% strain, at 1 Hz) in serum‐free tissue culture. Cells remained viable, as did collagen structure and mechanical properties in all tested conditions. Cell morphology in mechanically loaded tendon explants approximated native tendon, whereas load‐deprived tendons lost their native cell morphology. These losses were reflected in altered gene expression, with mechanical loading tending to maintain tendon specific and matrix remodeling genes phenotypic of native tissue. We conclude from this study that ex vivo load deprivation of murine tendon in minimal culture medium results in a degenerative‐like phenotype. We further conclude that onset of tissue degeneration can be suppressed by low‐magnitude mechanical loading. Thus a minimal explant culture model featuring serum‐free medium with low mechanical loads seems to provide a useful foundation for further investigations. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1383–1390, 2018.
TriviaQA: A Large Scale Distantly Supervised Challenge Dataset for Reading Comprehension

We present TriviaQA, a challenging reading comprehension dataset containing over 650K question-answer-evidence triples. TriviaQA includes 95K question-answer pairs authored by trivia enthusiasts and independently gathered evidence documents, six per question on average, that provide high quality distant supervision for answering the questions. We show that, in comparison to other recently introduced large-scale datasets, TriviaQA (1) has relatively complex, compositional questions, (2) has considerable syntactic and lexical variability between questions and corresponding answer-evidence sentences, and (3) requires more cross sentence reasoning to find answers. We also present two baseline algorithms: a feature-based classifier and a state-of-the-art neural network, that performs well on SQuAD reading comprehension. Neither approach comes close to human performance (23% and 40% vs. 80%), suggesting that TriviaQA is a challenging testbed that is worth significant future study.
What do we mean by health?

The main objective of the doctor's work, in whatever field he or she functions, is ultimately the restoration and maintenance of health. Yet, as Smith pointed out some time ago, disease and health are ‘slippery concepts’ that we have not been able to define clearly hitherto.1 The difficulty of defining health was clearly illustrated when the distinguished figures of the World Health Organisation (WHO) were asked to undertake this task in 1948. Their response was that ‘health is a state of complete physical, mental and social wellbeing and not merely the absence of disease or infirmity’. 2 Now, a definition should define clearly the nature of a subject as it is or by what effect it has; that is, what it does. In addition, in the fields of science and medicine, it should indicate how the subject is produced and enable it to be measured. The WHO definition did none of these things — it merely took one vague entity ‘health’ and defined it in terms of another equally obscure concept, ‘wellbeing’. It did, however, point out that there was more to health than simply the absence of disease, but this was not really a definition at all, being merely a rather vague description. The waters remained as muddy as ever and the measurement of health was in no way facilitated. Incidentally, the Oxford English Dictionary is no more precise on this subject. It offers a number of meanings including ‘soundness of body, that condition in which functions are duly discharged, spiritual, moral or mental soundness, salvation, well-being, safety and deliverance’ — all parts of the picture, but a real definition is still some way off. Now one does not have to be Wittgenstein to recognise the absurdity of the situation in which doctors regard health as the main …
Chiral aspects of the human metabolism of ethosuximide

Ethosuximide is a chiral drug substance primarily indicated for the treatment of absence seizures. This drug is used clinically as the racemate. The human urinary metabolites of ethosuximide (I) have been studied using chiral gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS). The metabolites identified were the previously reported unchanged ethosuximide (I) enantiomers, all four stereoisomers of 2‐(1‐hydroxyethyl)‐2‐methylsuccinimide (II), and the four stereoisomers of 2‐ethyl‐3‐hydroxy‐2‐methylsuccinimide (III). Through chemical derivatization methodology and GC/MS (using electron impact ionization [EI] and chemical ionization [CI] techniques) two enantiomers of a previously unreported metabolite of ethosuximide, 2‐ethyl‐2‐hydroxymethylsuccinimide (VI), have been identified. Copyright © 2005 John Wiley & Sons, Ltd.
Influence de la densite de plantation sur le comportement agronomique de la vigne et sur la qualite des vins: essais sur Chasselas. 2. Resultats oenologiques

Un essai d'ecartement des rangs combine avec differentes hauteurs de la haie foliaire et differents niveaux de rendement a ete mis en place en 1986 avec le cepage Chasselas au domaine experimental de la Station federale de Changins a Pully (VD). Avec un meme nombre de grappes par cep, l'accroissement de l'ecartement des rangs a provoque une forte diminution du rendement par unite de surface sans ameliorer la teneur en sucre des mouts. Avec un meme niveau de rendement a la surface, la richesse en sucre des mouts a eu tendance a diminuer avec l'ecartement des rangs. La distance interligne et la hauteur de feuillage n'ont exerce que peu d'effet sur les parametres lies a l'acidite des mouts et des vins. L'analyse sensorielle des vins a montre que les differences de qualite etaient faibles et rarement significatives. Les vins des variantes a plus faibles ecartements (120 et 160 cm) ont eu tendance a etre legerement mieux apprecies que ceux des variantes a interlignes plus larges (200 et 240 cm).
Enablers and Mechanisms: Practices for Achieving Synergy with Business Analytics

Business Analytics (BA) systems use advanced statistical and computational techniques to analyze organizational data and enable informed and insightful decision-making. BA systems interact with other organizational systems and if their relationship is synergistic, together they create higher-order BA-enabled organizational systems, which have the potential to create value and gain competitive advantage. In this paper, we focus on the enablers and mechanisms of synergy between BA and other organizational systems and identify a set of organizational practices that underlie the emergence of BA-enabled organizational systems. We use a case study involving a large IT firm to identify the organizational practices associated with synergistic relationships that lead to the emergence of higher-order BA-enabled organizational systems.
ORF 73-Null Murine Gammaherpesvirus 68 Reveals Roles for mLANA and p 53 in Virus Replication

Gammaherpesviruses establish lifelong, latent infections in host lymphocytes, during which a limited subset of viral gene products facilitates maintenance of the viral episome. Among the gamma-2-herpesvirus (rhadinovirus) subfamily, this includes expression of the conserved ORF73-encoded LANA proteins. We previously demonstrated by loss-of-function mutagenesis that the murine gammaherpesvirus 68 (MHV68) ORF73 gene product, mLANA, is required for the establishment of latency following intranasal inoculation of mice (N. J. Moorman, D. O. Willer, and S. H. Speck, J. Virol. 77:10295–10303, 2003). mLANA-deficient viruses also exhibited a defect in acute virus replication in the lungs of infected mice. The latter observation led us to examine the role of mLANA in productive viral replication. We assessed the capacity of mLANA-deficient virus (73.Stop) to replicate in cell culture at low multiplicities of infection (MOIs) and found that 73.Stop growth was impaired in murine fibroblasts but not in Vero cells. A recombinant virus expressing an mLANA-green fluorescent protein (GFP) fusion revealed that mLANA is expressed throughout the virus replication cycle. In addition, 73.Stop infection of murine fibroblasts at high MOIs was substantially more cytotoxic than infection with a genetically repaired marker rescue virus (73.MR), a phenotype that correlated with enhanced kinetics of viral gene expression and increased activation of p53. Notably, augmented cell death, viral gene expression, and p53 induction were independent of viral DNA replication. Expression of a mLANA-GFP fusion protein in fibroblasts correlated with both reduced p53 stabilization and reduced cell death following treatment with p53-inducing agonists. In agreement, accentuated cell death associated with 73.Stop infection was reduced in p53-deficient murine embryonic fibroblasts. Additionally, replication of 73.Stop in p53-deficient cells was restored to levels comparable to those of 73.MR. More remarkably, the absence of p53 led to an overall delay in replication for both 73.Stop and 73.MR viruses, which correlated with delayed viral gene expression, indicating a role for p53 in MHV68 replication. Consistent with these findings, the expression of replicationpromoting viral genes was positively influenced by p53 overexpression or treatment with the p53 agonist etoposide. Overall, these data demonstrate the importance of mLANA in MHV68 replication and suggest that LANA proteins limit the induction of cellular stress responses to regulate the viral gene expression cascade and limit host cell injury.
Level of antioxidant vitamins in children suffering from pneumonia

Oxidant antioxidant balance is essential for the normal lung function. Both an increased oxidants and/or decreased antioxidants may reverse the physiologic oxidant antioxidant balance in favour of oxidant leading to lung injury. The aim of present study was to examine the levels of vitamin E & C in children who were suffering from pneumonia. 40 pneumonia children and 40 controls matched with age were analyzed for the study. We observed that highly significant decrease in the concentrations of vitamin E & vitamin C was seen in chil-dren with pneumonia compared to controls (p<0.001) respectively. Also there was increased ratio of vitamin E & vitamin C in patients with pneumonia as compared to the controls.
Two sphingolipid transfer proteins, CERT and FAPP2: Their roles in sphingolipid metabolism

Recent discoveries of two sphingolipid transfer proteins, CERT and FAPP2, have brought the field of sphingolipid metabolism to a more dynamic stage. CERT transfers ceramide from the endoplasmic reticulum (ER) to the Golgi apparatus, a step crucial for sphingomyelin (SM) synthesis. The pleckstrin homology (PH) domain and the FFAT motif of CERT restrict the direction of transfer and destination of ceramide through binding to phosphatidylinositol 4‐monophosphate (PI4P) at the Golgi and the ER resident proteins, VAPs, respectively. CERT is regulated by the phosphorylation and dephosphorylation of serine/threonine, in which protein kinase D, possibly casein kinase I, and PP2Cε are involved. On the other hand, FAPP2 transfers glucosylceramide (GlcCer) to appropriate sites for the synthesis of complex glycosphingolipids. Like CERT, FAPP2 contains a PH domain, the binding of which to PI4P is required for its localization to the Golgi. These observations indicate that lipid transfer proteins, CERT and FAPP2, spatially regulate lipid metabolism on the cytosolic side. © 2008 IUBMB IUBMB Life, 60(8): 511–518, 2008
EvoApproxSb: Library of approximate adders and multipliers for circuit design and benchmarking of approximation methods

Approximate circuits and approximate circuit design methodologies attracted a significant attention of researchers as well as industry in recent years. In order to accelerate the approximate circuit and system design process and to support a fair benchmarking of circuit approximation methods, we propose a library of approximate adders and multipliers called EvoApprox8b. This library contains 430 non-dominated 8-bit approximate adders created from 13 conventional adders and 471 non-dominated 8-bit approximate multipliers created from 6 conventional multipliers. These implementations were evolved by a multi-objective Cartesian genetic programming. The EvoApprox8b library provides Verilog, Matlab and C models of all approximate circuits. In addition to standard circuit parameters, the error is given for seven different error metrics. The EvoApprox8b library is available at: www.fit. vutbr.cz/research/groups/ehw/approxlib
Prediction of harmonic sound power generated by a modern turbofan with heterogeneous OGV and internal bifurcations

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Prediction of harmonic sound power generated by a modern turbofan with heterogeneous OGV and internal bifurcations V. Bonneau, C. Polacsek, R. Barrier, S. Lewy
It’s Complicated—In Fact, It’s Complex

Ceci, Ginther, Kahn, and Williams present a comprehensive and well-reasoned review of the theories and research specific to “gender gaps” in academic science and mathematics. They describe the large and diverse body of research that addresses this question as “contradictory,” but I think a better term is “confounded. ” To their credit, these authors have helped to unconfound the many variables that contribute to gender gaps in academic careers. Ceci et al. have uncovered several important relationships that advance our understanding of why women and men tend to enter different fields of academic science. For readers who are wondering why they should care about gender gaps in academic science, I offer three reasons. First, there is a dwindling pool of mathematicians and scientists in the United States and many other countries. We are not attracting or are losing talented women who could be leaders in fields that will improve the economy, address pressing societal issues (e.g., problems of pollution), and advance development in health care, planetary science, and many other science and mathematics disciplines. Second, questions about gender gaps in academic science are intrinsically related to broader questions about why men and women predominate in different spheres of life. The way we answer questions about gender gaps in academic science has implications for a wide range of questions about the ways in which women and men are similar and different. Third, implications about numerous public-policy issues flow from our understanding of gender-achievement gaps, including the efficiency of affirmative-action programs based on gender, sex-segregated schooling, child-rearing practices, and family-friendly work policies.