Miracle-dz/UniFAR-FTUs huggingface dataset:
Demand and Revenue Impacts of an Opaque Channel: Evidence from the Airline Industry

Over time, opaque intermediaries, such as Hotwire and Priceline.com, have become an established distribution channel for the travel industry. We use a market response model and a dataset of economy class reservations from a major international airline to empirically examine the demand and cannibalization effects of the opaque channel. We find that: (1) the impact of the opaque channel on total demand is positive and significant in markets with high levels of competition; and (2) overall, the opaque channel cannibalizes the online transparent channel, but not the offline channel nor the full‐fare segment. However, we find that cannibalization of the offline channel moderately increases as markets become more concentrated. These results together suggest that airlines can benefit from opaque offerings mainly in markets with high levels of competition. Further, we develop a methodology to assess the revenue impacts of the opaque channel and show how it can be used by managers to develop and implement pricing tactics to increase demand and decrease cannibalization.
Similarities and differences between Caucasian and African American college women on eating and dieting expectancies, bulimic symptoms, dietary restraint, and disinhibition.

OBJECTIVE To clarify race differences in eating disorder risk factors and symptoms, by comparing Caucasian and African American samples on the factor structures, intercorrelations, and mean levels of endorsement on a set of risk and symptom measures. METHOD A sample of 300 Caucasian and 200 African American undergraduates completed measures of eating and thinness/dieting expectancies, the Three-Factor Eating Questionnaire (TFEQ), and the BULIT. RESULTS The factor structures of each measure were invariant across race. Intercorrelations among the measures generally did not differ across race. On the three expectancy measures predictive of symptomatology, two of three scales of the TFEQ, and the BULIT, African American women had lower mean scores than Caucasian women. Socioeconomic status did not account for the results: in this sample, it was unrelated to race and correlated with only 1 of 20 measures. DISCUSSION The factor-based meaning of these measures appears to be consistent across race. The measures correlate similarly across race, suggesting that the risk process may be similar for both races, but African American women endorsed significantly fewer risk factors and fewer symptoms.
Schizophrenia patients with a history of childhood trauma have a pro-inflammatory phenotype

Background Increasing evidence indicates that childhood trauma is a risk factor for schizophrenia and patients with this syndrome have a pro-inflammatory phenotype. We tested the hypothesis that the pro-inflammatory phenotype in schizophrenia is associated with childhood trauma and that patients without a history of such trauma have a similar immune profile to healthy controls. Method We recruited 40 schizophrenia patients and 40 controls, all of whom completed the Childhood Trauma Questionnaire (CTQ). Using enzyme-linked immunosorbent assay (ELISA) techniques, we measured peripheral levels of interleukin (IL)-1β, IL-6, IL-8 and tumour necrosis factor (TNF)-α. These immune parameters were compared in schizophrenia with childhood trauma, schizophrenia without childhood trauma and healthy controls. Results Patients with childhood trauma had higher levels of IL-6 and TNF-α than patients without trauma and healthy controls, and TNF-α levels correlated with the extent of the trauma. Patients with no trauma had similar immune profiles to controls. Conclusions Childhood trauma drives changes, possibly epigenetic, that generate a pro-inflammatory phenotype.
The potential benefit of a hybrid operating environment among severely injured patients with persistent hemorrhage: How often could we get it right?

BACKGROUND Selecting the appropriate initial destination (operating theater [OR], angiography suite, or intensive care unit [ICU]) in persistently hypotensive injured patients can be extremely challenging. The purpose of this study was to define the flow, interventions, and outcomes of these patients. METHODS All persistently hypotensive (two or more systolic blood pressures < 90 mmHg) severely injured (Injury Severity Score [ISS] ≥ 12) adult patients (1995–2012) were analyzed over the first 24 hours at a Level I trauma referral center. Standard statistical methodology was used (p < 0.05). RESULTS Of 911 patients with an initial systolic blood pressure of less than 90 mm Hg (prehospital or initial trauma bay reading), 56% remained persistently hypotensive. These patients had a mean age of 41 years, were 73% male, and blunt injured in 87% of the cases. Initial destinations included the OR (53%), ICU (29%), trauma ward (13%) after resuscitation and diagnostic imaging, and interventional angiography suite (5%). Of all hypotensive patients, 67% received computed tomography either before or after initial transfer from the trauma bay. Of the patients who were moved to the OR, 64% were subsequently transferred to the ICU and 23% to the ward, and 14% died in the OR itself. Within the OR, 97% of the patients underwent an intervention (79% laparotomies). A total of 7% of the patients required both emergent operative and angiographic interventions. These were most commonly due to ongoing hemorrhage from pelvic fractures or major hepatic lacerations. Mortality was higher in patients who underwent operation before angiography (90% vs. 32%, p = 0.002). The median hospital length of stay was 22 days (ICU stay, 8 days). The mortality (<24 hours) of all persistently hypotensive patients was 22%. CONCLUSION Up to 7% of patients in this cohort could benefit from the utility of a hybrid RAPTOR [Resuscitation with Angiography, Percutaneous Therapy Operative Repair] suite. A “direct to the RAPTOR suite” policy (i.e., bypass emergency department) must be used with caution. LEVEL OF EVIDENCE Therapeutic study, level IV.
Racial-Ethnic Disparities in Management and Outcomes Among Children With Type 1 Diabetes

BACKGROUND AND OBJECTIVES: Previous research has documented racial/ethnic disparities in diabetes treatments and outcomes. It remains controversial whether these disparities result from differences in socioeconomic status (SES) or other factors. We examined racial/ethnic disparities in therapeutic modalities and diabetes outcomes among the large number of pediatric participants in the T1D Exchange Clinic Registry. METHODS: The cohort included 10 704 participants aged <18 years with type 1 diabetes for ≥1 year (48% female; mean age: 11.9 ± 3.6 years; diabetes duration: 5.2 ± 3.5 years). Diabetes management and clinical outcomes were compared among 8841 non-Hispanic white (white) (83%), 697 non-Hispanic black (black) (7%), and 1166 Hispanic (11%) participants. The population included 214 high-income black and Hispanic families. RESULTS: Insulin pump use was higher in white participants than in black or Hispanic participants (61% vs 26% and 39%, respectively) after adjusting for gender, age, diabetes duration, and SES (P < .001). Mean hemoglobin A1c was higher (adjusted P < .001) in black participants than in white or Hispanic participants (9.6%, 8.4%, and 8.7%). More black participants experienced diabetic ketoacidosis and severe hypoglycemic events in the previous year than white or Hispanic participants (both, P < .001). There were no significant differences in hemoglobin A1c, diabetic ketoacidosis, or severe hypoglycemia between white and Hispanic participants after adjustment for SES. CONCLUSIONS: Even after SES adjustment, marked disparities in insulin treatment method and treatment outcomes existed between black versus Hispanic and white children within this large pediatric cohort. Barriers to insulin pump use and optimal glycemic control beyond SES should be explored in all ethnic groups.
Impact of HIV test counseling on college students' sexual beliefs and behaviors.

OBJECTIVE To compare the health beliefs and risky sexual behaviors of college students who did and did not seek HlV testing. METHODS A survey was administered, and testing sessions were content analyzed. RESULTS There were no significant differences in health beliefs, but students surveyed perceived themselves to be invulnerable to HIV/AIDS despite unsafe sexual behaviors. Sexual behaviors varied with students who sought HIV testing practicing more unsafe vaginal and oral intercourse. Assessment of the intervention suggested that counseling sessions were influential in persuading students to rethink their health beliefs and change their risky sexual behaviors. CONCLUSION Testing can be used as both a prevention tool and a way to determine college students' HIV status.
ANALISIS FAKTOR - FAKTOR YANG MEMPENGARUHI KEBIJAKAN DIVIDEN

The study examines the effect of profitability, laverage, collateralizable assets, size, growth, current ratio, and investment opportunity on dividend policy. This research was conducted at the Indonesian Stock Exchange by using using a go public manufacturing company as the unit of analysis. The sampling method use purposive sampling with the observasion period from 2011 to 2013. Relationship and (or) influence betmeen variable is described by using multiple regression analysis. The result showed that profitability, laverage, collateralizable assets, current ratio, and investment opportunity have positive effect and significant to dividend policy. Whereas growth and size have positif and no significant effect on dividend policy. Keywords: Dividend Policy, Profitability, Laverage, Collateralizable Assets, Size, Growth, Current Ratio and Investment Opportunity
“It was like leaving your family”: Gentrification and the impacts of displacement on public housing tenants in inner‐Sydney

In March 2014, the minister responsible announced that all of the approximately 600 public housing tenants of Millers Point and the Sirius Building in inner Sydney are to be moved and the properties sold. Millers Point is probably the oldest public housing area in Australia. The Sirius Building was purpose built for public housing tenants in the late 1970s. The article briefly examines the gentrification process in the Millers Point area. However, the main focus, drawing on six in-depth interviews with public housing tenants who are still residents in the area and 13 who have moved, is an examination of the impact of the government's removal announcement and the actual displacement of residents. What this article illustrates is that the place attachment of most of the interviewees was profound and the removal announcement and the actual move were devastating. Interviewees spoke of deep sadness and anxiety at the thought of leaving what they considered a unique and genuine community. Residents who had moved told of their isolation and melancholy at having lost their local social network. The research shows that the human cost of policies and not revenue should always be the central consideration.
Medical student storytelling on an institutional blog: A case study analysis

Abstract Background: Despite the proclivity and proliferation of blogs on the Internet, the use of blogs at medical institutions is not well documented. Aims: In examining the structured stories that medical students share with the digital community, we may better understand how students use institutional blogs to discuss their medical school experiences while maintaining their role as a medical student ambassador for the program. Methods: We conducted a case study to analyze the stories within 309 medical student blogs from one medical institution in the United States. Results: In an attempt to communicate their experiences to different benefactors, student bloggers engaged in structured and personal storytelling. Structured stories offered medical school advice to prospective students, while personal stories embodied features of a personal diary where students recounted significant milestones, talked about personal relationships and engaged in emotional reflection and disclosure. Conclusion: Institutional blogs may provide social marketing for medical institutions, as students strategically framed their experiences to reflect a positive attitude about the medical institution and focused on providing advice to prospective students. Although these structured stories limit complete disclosure, students may still achieve benefits by engaging in emotional disclosure and personal reflection.
Reliability comparison of matrix and other converter topologies

Several rectifier-inverter and matrix converter topologies suitable for aerospace applications are compared, and their reliability is predicted. The military handbook MIL-HDBK-217F guidelines have been used to predictreliability. The matrix converter has several attractive features for aerospace applications such as potential size and weight savings. Although the matrix converter has a higher number of semiconductor switches, they are subjected to a lower voltage stress, which decreases their failure rate. This results in the reliability indicators of the different converter topologies being very similar
Tumor necrosis factor receptor‐associated factor 6 participates in early brain injury after subarachnoid hemorrhage in rats through inhibiting autophagy and promoting oxidative stress

Tumor necrosis factor receptor‐associated factor 6 (TRAF6) is a member of the TRAF family and an important multifunctional intracellular adaptin of the tumor necrosis factor superfamily and toll/IL‐1 receptor (TIR) superfamily. TRAF6 has been studied in several central nervous system diseases, including ischemic stroke, traumatic brain injury, and neurodegenerative diseases, but its role in subarachnoid hemorrhage (SAH) has not been fully illustrated. This study was designed to explore changes of expression level and potential roles and mechanisms of TRAF6 in early brain injury (EBI) after SAH using a Sprague–Dawley rat model of SAH induced in 0.3 mL non‐heparinized autologous arterial blood injected into the pre‐chiasmatic cistern. First, compared with the sham group, we found that the expression levels of TRAF6 increased gradually and peaked at 24 h after SAH. Second, the results showed that application of TRAF6 over‐expression plasmid and genetic silencing siRNA could increase or decrease expression of TRAF6, respectively, and severely exacerbate or relieve EBI after SAH, including neuronal death, brain edema, and blood–brain barrier injury. Meanwhile, the levels of autophagy and oxidative stress were reduced and increased separately. Finally, GFP‐TRAF6‐C70A, which is a TRAF6 mutant that lacks E3 ubiquitin ligase activity, was used to explore the mechanism of TRAF6 in SAH, and the results showed that EBI and oxidative stress were reduced, but the levels of autophagy were increased under this condition. Collectively, these results indicated that TRAF6 affected the degree of EBI after SAH by inhibiting autophagy and promoting oxidative stress.
Uncoupling of oxidative phosphorylation: different effects of lipophilic weak acids and electrogenic ionophores on the kinetics of ATP synthesis.

Previous studies from this laboratory have shown that the kinetics of ATP synthesis by bovine heart submitochondrial particles (SMP) are modulated by the coupled rate of respiration between two extremes of Vmax and apparent Km's for ADP and Pi [Matsuno-Yagi, A. , & Hatefi, Y. (1986) J. Biol. Chem. 261, 14031-14038; Hekman, C. , Matsuno-Yagi, A. , & Hatefi, Y. (1988) Biochemistry 27, 7559-7565]. Thus, with ADP as the variable substrate, ATP synthesis occurred with Vmax = 200 nmol of ATP min-1 (mg of protein)-1 at 30 degrees C and an apparent KmADP = 2-4 microM at low rates of respiration, and with Vmax = 11,000 nmol of ATP min-1 (mg of protein)-1 at 30 degrees C and an apparent KmADP = 120-160 microM at high rates of respiration. At intermediate respiration rates, it was necessary to introduce a third intermediate KmADP for best fit of the kinetic data, indicating that transition from one kinetic extreme to the other is not abrupt and involves intermediate kinetic states of the ATP synthase complexes. The present paper shows that uncouplers affect the kinetics of ATP synthesis by SMP in two ways. When used at moderate concentrations, electrogenic ionophores such as gramicidin D or valinomycin plus nigericin decreased the Vmax for ATP synthesis without changing the contributions of the low, intermediate, and high KmADP to the overall rate of ATP synthesis. By contrast, potent lipophilic weak acid uncouplers, such as FCCP, CCCP, S-13, and SF6847, decreased Vmax and converted the kinetics of ATP synthesis toward high KmADP. (ABSTRACT TRUNCATED AT 250 WORDS)
Interpreting trial results in light of conflicting evidence: a Bayesian analysis of adjuvant chemotherapy for non-small-cell lung cancer.

PURPOSE When successive randomized trials contradict prior evidence, clinicians may be unsure how to evaluate them: Does accumulating evidence warrant changing practice? An increasingly popular solution, Bayesian statistics quantitatively evaluate new results in context. This study provides a clinically relevant example of Bayesian methods. METHODS Three recent non-small-cell lung cancer adjuvant chemotherapy trials were evaluated in light of prior conflicting data. Results were used from International Adjuvant Lung Trial (IALT), JBR.10, and Adjuvant Navelbine International Trialist Association (ANITA). Prior evidence was sequentially updated to calculate the probability of each survival benefit level (overall and by stage) and variance. Sensitivity analysis was performed using expert opinion and uninformed estimates of survival benefit prior probability. RESULTS The probability of a 4% survival benefit increased from 33% before IALT to 64% after IALT. After sequential updating with JBR.10 and ANITA, this probability was 82% (hazard ratio = 0.84; 95% CI, 0.77 to 0.91). IALT produced the largest decrease in variance (61%) and decreased the chance of survival decrement to 0%. Sensitivity analysis did not support a survival benefit after IALT. However, sequential updating substantiated a 4% survival benefit and, for stage II and III, more than 90% probability of a 6% benefit and 50% probability of a 12% benefit. CONCLUSION When evaluated in context with prior data, IALT did not support a 4% survival benefit. However, sequential updating with JBR.10 and ANITA did. A model for future assessments, this study demonstrates the unique ability of Bayesian analysis to evaluate results that contradict prior evidence.
Relationship Between Nutritional Knowledge and the Amount of Sugar-Sweetened Beverages Consumed in Los Angeles County

Although consumption of sugar-sweetened beverages (SSBs) is associated with many negative health outcomes, including obesity, diabetes, and cardiovascular disease, the relationship between consumer nutritional knowledge and the amount consumed is poorly understood. The objective of this study was to examine the relationship between knowledge of daily calorie recommendations and the amount of SSBs consumed in a large, economically and racially diverse sample of adults recruited at selected Metro subway and bus shelters in Los Angeles County. In June 2012, the Los Angeles County Department of Public Health conducted street intercept surveys to assess food attitudes and consumption behaviors and public opinions related to a recent 8-week health marketing campaign targeting SSB consumption. Descriptive and comparative analyses were conducted, including a negative binomial regression model, to examine the relationship between knowledge of the daily calorie recommendations and the amount of SSBs consumed. Among survey respondents (n = 1,041), less than one third correctly identified the daily calorie recommendations for a typical adult. After controlling for sociodemographics and weight status, respondents who correctly identified recommended calorie needs reported, on average, drinking nine fewer SSBs per month than respondents who did not. Results suggest that efforts to reduce SSB consumption might benefit from the inclusion of educational interventions that empower consumers to make healthy choices.
Investment in Financial Structured Products from Rational and Behavioral Choice Perspectives

Structured products (SP) are synthetic investment instruments specially designed to meet specific needs that cannot be met by acquiring standard financial instruments available in the markets. We argue that many SP currently available to retail investors are designed to exploit several behavioral biases including: loss aversion, the disposition effects, herd behavior, the ostrich effect and the hindsight bias. We perform an experiment that examines investor decision-making in relation to SP investments. Our findings demonstrate that investors tend to be affected by th se behavioral biases, which favor SP investments. Accordingly, regulation dealing specifically with SP may be warranted to improve investor protection. We offer a regulation that would compel issuers to reveal the effective fees they charge investors. In disclosing the effective fees, investors will be able to improve their decisions and will be able to evaluate the costs of their behavioral biases.
PGE2 Causes Mesangial Cell Hypertrophy and Decreases Expression of Cyclin D3

Background/Aims: Glomerular hypertrophy is a feature of many glomerular diseases and is associated with the development of renal failure. We previously demonstrated that the cyclooxygenase 2 inhibitor, NS398, reduced glomerular size after uninephrectomy. Thus, we hypothesized that prostaglandin (PG) E2 would cause mesangial cell hypertrophy in vitro. Methods: We used a mesangial cell line and primary culture of rat mesangial cells. The effects of PGE2 on mesangial cell hypertrophy were determined using immunohistochemistry and image analysis to assess cell size, 3H-leucine incorporation as a measure of protein synthesis and flow cytometry to assess cell cycle status. Western blot was used to examine the effect of PGE2 on expression of cyclin D3, p15, p27 and cyclin-dependent kinase 4 – known regulators of the cell cycle. Results: PGE2 increased cell size by 13% and protein synthesis (3H-leucine incorporation) by 35% over 24 h. By flow cytometry, PGE2 increased the percentage of cells in G0/G1 phase of the cell cycle from 70.13 ± 1.01 to 74.06 ± 1.18% and conversely, decreased the number of cells in S phase from 24.07 ± 1.06 to 22.03 ± 0.78%. The number of cells in G2/M was also reduced. Expression of cyclin D3 was decreased by 60% after treatment with PGE2, while expression of p27 was increased. The effects of PGE2 on cell size and flow cytometry were reproduced by the prostaglandin E2 receptors EP1/EP3 agonist sulprostone. Conclusion: PGE2 induces mesangial cell hypertrophy and cell cycle arrest via its EP1 receptor.