Miracle-dz/UniFAR-FTUs huggingface dataset:
Infertility in Cryptorchidism Is Linked to the Stage of Germ Cell Development at Orchidopexy

Background: Cryptorchidism represents the most common endocrine disease in boys, with infertility frequently observed in unilateral as well as bilateral forms. In this study, we examined the role of Ad (dark) spermatogonia for fertility in cryptorchid boys. The hypothesis to be proven was that boys lacking Ad spermatogonia will develop infertility despite a successful orchidopexy at an early age. Methods: To estimate total sperm count, one of the most predictive parameters of male fertility, we analyzed the ejaculatein 218 cryptorchid men and correlated it with the developmental stage of their germ cells at the time of successful surgery. Results: Abnormal sperm concentration (<40 × 106/ejaculate) was found in half of the patients under the study. 47.5% of unilateral and 78% of bilateral cryptorchid males had their sperm concentration in the infertility range according to the WHO standards. If transformation into Ad spermatogonia had occured, age-related differences in the fertility outcome was observed. The younger the unilateral cryptorchid boys were at surgery, the higher their sperm count. Age-related difference was not found in the group of cryptorchid men having had no A dark spermatogonia at time of surgery, indicating that in this group a successful orchidopexy is insufficient to prevent infertility development and, in particular, the development of azoospermia. Conclusion: The presence of Ad spermatogonia at surgery is an excellent prognostic parameter for future fertility. Cryptorchid boys lacking these cells will develop infertility despite successful orchidopexy at an early age.
Assessing Diachronic Reasoning: Exploratory Measures of Perceived Self-Change in Young Adults

Personal persistence, the subjective perception of self-sameness through time, is implied or explicitly asserted in nearly all modern theories of self and identity. Recently, personal persistence has become the subject of inquiry and argument, most directly due to Galen Strawson, who recently described himself as experiencing a distinct series of non-defective and non-pathological selves, each phenomenologically independent of the other. Using a combination of previously published, modified, and newly constructed measures, the present study, in an attempt to provide empirical information relevant to the theoretical treatments of personal persistence, assembled an assessment battery of assumptively intercorrelated personal persistence measures, which collectively provided dichotomous, linear, quantitative, and qualitative information about the experience of self-persistence in a sample of 177 mostly female college students between the ages of 18 and 44 years.
Determination of Zinc Oxide Nanoparticles Toxicity in Root Growth in Wheat (Triticum Aestivum L.) Seedlings

The effect of zinc oxide nanoparticles (ZnONPs) was studied in wheat (Triticum aestivum L.) seedlings under in vitro exposure conditions. To avoid precipitation of nanoparticles, the seedlings were grown in half strength semisolid Murashige and Skoog medium containing 0, 50, 100, 200, 400 and 500 mg L^–1 of ZnONPs. Analysis of zinc (Zn) content showed signifcant increase in roots. In vivo detection using fuorescent probe Zynpyr-1 indicated accumulation of Zn in primary and lateral root tips. All concentrations of ZnONPs signifcantly reduced root growth. However, signifcant decrease in shoot growth was observed only after exposure to 400 and 500 mg L^–1 of ZnONPs. The reactive oxygen species and lipid peroxidation levels signifcantly increased in roots. Signifcant increase in cell-wall bound peroxidase activity was observed after exposure to 500 mg L^–1 of ZnONPs. Histochemical staining with phloroglucinol-HCl showed lignifcation of root cells upon exposure to 500 mg L^–1 of ZnONPs. Treatment with propidium iodide indicated loss of cell viability in root tips of wheat seedlings. These results suggest that redox imbalances, lignifcation and cell death has resulted in reduction of root growth in wheat seedlings exposed to ZnONPs nanoparticles.
The Impact of Oxidative Stress on the Bone System in Response to the Space Special Environment

The space special environment mainly includes microgravity, radiation, vacuum and extreme temperature, which seriously threatens an astronaut’s health. Bone loss is one of the most significant alterations in mammalians after long-duration habitation in space. In this review, we summarize the crucial roles of major factors—namely radiation and microgravity—in space in oxidative stress generation in living organisms, and the inhibitory effect of oxidative stress on bone formation. We discussed the possible mechanisms of oxidative stress-induced skeletal involution, and listed some countermeasures that have therapeutic potentials for bone loss via oxidative stress antagonism. Future research for better understanding the oxidative stress caused by space environment and the development of countermeasures against oxidative damage accordingly may facilitate human beings to live more safely in space and explore deeper into the universe.
Perceived Maternal Parenting Self-Efficacy (PMP S-E) tool: development and validation with mothers of hospitalized preterm neonates.

AIM This paper is a report of a study to develop and test the psychometric properties of the Perceived Maternal Parenting Self-Efficacy tool. BACKGROUND Mothers' perceptions of their ability to parent (maternal parenting self-efficacy) is a critical mechanism guiding their interactions with their preterm newborns. A robust measure is needed which can measure mothers' perceptions of their ability to understand and care for their hospitalized preterm neonates as well as being sensitive to the various levels and tasks in parenting. METHODS Using a mixed sampling methodology (convenience or randomized cluster control trial) 165 relatively healthy and hospitalized mother-preterm infant dyads were recruited in 2003-2005 from two intensive care neonatal units in the United Kingdom (UK). Mothers were recruited within the first 28 days after giving birth to a preterm baby. The Perceived Maternal Parenting Self-Efficacy tool, which is made up of 20 items representing four theorized subscales, was tested for reliability and validity. RESULTS Internal consistency reliability of the Perceived Maternal Parenting Self-Efficacy tool was 0.91, external/test-retest reliability was 0.96, P<0.01. Divergent validity using the Maternal Self-Report Inventory was r(s)=0.4, P<0.05 and using the Maternal Postnatal Attachment Scale was r(s)=0.31, P<0.01. CONCLUSION The Perceived Maternal Parenting Self-Efficacy tool is a psychometrically robust, reliable and valid measure of parenting self-efficacy in mothers of relatively healthy hospitalized preterm neonates. Although application outside the UK will require further cross-cultural validation, the tool has the potential to provide healthcare professionals with a reliable method of identifying mothers of preterm hospitalized babies who are in need of further support.
Physiology of H I horizontal cells in the primate retina

Two types of recording were obtained from horizontal cells in the superfused eyecup preparation of the retina of Macaca mulatta. Injection of horseradish peroxidase showed that one class of responses was generated by the cell body of H I horizontal cells. The origin of the other type of responses was not identified morphologically, but they were strikingly similar to those recorded from the axonal arborization of axon-bearing horizontal cells of other mammalian species. The soma of H I cells responded with graded hyperpolarizations to increasing changes in diffuse white-light illumination. Threshold responses were obtained with stimulus intensities above electroretinogram (ERG) b-wave threshold; this was taken as an indication of cone input to this part of the cell. Responses to low-intensity stimuli were small, sustained hyperpolarizations; at intermediate intensities, the hyperpolarizations were initiated by a prominent transient component and were followed by a small rod after-effect at stimulus termination; with bright flashes, the transient component was abolished and the rod after-effect became larger. The spectral input of the H I cell body was tested with chromatic stimuli matching the spectral sensitivity of primate cone pigments: responses to all wavelengths were hyperpolarizations. Spectral sensitivity values for the different wavelengths and a comparison of the spectral amplitude–intensity curves for 450 nm, 540 nm and 630 nm wavelengths suggested that H I cell bodies had a non-specific, broad-band sensitivity to mid-spectral wavelengths. Thus more than one spectrally sensitive mechanism was involved in the generation of their response and they were not univariant. This was supported by the morphological observation that the clusters of terminal dendritic branchlets of H I cells had the same arrangement and distance from each other as the overlying cone inner segments, suggesting that these cells contact cones in an indiscriminate fashion. The other class of horizontal cell responses were characterized by a lower threshold, a larger amplitude with low intensity stimuli, a steeper increment in amplitude with increasing intensity, a saturation at moderate levels of illumination and a prominent rod after-effect in response to bright-light stimuli. We concluded that these responses were generated by the axon terminal of H I horizontal cells, that receives synaptic input from rods. Thus H I horizontal cells belong to the luminosity type, are not involved in the processing of colour contrast and are homologous to the axon-bearing horizontal cells of other mammalian retinas.
Evaluation of competencies in the field of vocational rehabilitation and the employment of persons with disabilities

For decades, employment of a person with disabilities has been considered a key indicator of the success of vocational rehabilitation. There is a link between the quality of vocational rehabilitation and a better quality of life for service users; these services have a significant impact on efficiency in the field of work. Very few authors have researched the qualification and skills of rehabilitation experts essential for successfully carrying out their professional activities. The objective of the present study was to investigate the perceived importance attached to the competencies of vocational rehabilitation professionals and the frequency of their application at work in three different countries, which was conducted using a questionnaire that was prepared on the basis of a questionnaire designed by Australian researchers. Basic competencies comprise four sets: vocational counselling, professional practice, personal counselling and rehabilitation case management. Special competencies are composed of two sets: workplace disability case management and workplace intervention and programme management. The questionnaire was completed by 131 respondents, of whom 61 were from Slovenia, 34 were from Austria and 36 were from the UK. t-Tests for two independent samples (sex), analysis of variance (type of education, country) and Pearson’s correlation coefficient were used to compare the perception of basic and special competencies. The respondents perceived personal counselling, vocational counselling and management of rehabilitation cases as being the most important, whereas the least importance was assigned to interventions. In practice, the respondents used personal counselling most frequently and very few interventions.
Newspaper coverage of HIV/AIDS in China from 2000 to 2010

Mass media in China play a significant role in the dissemination of HIV/AIDS knowledge to the general public. Previous studies have described how the Chinese mass media portray HIV/AIDS in general, but no study has yet to examine changes in patterns of HIV/AIDS reporting over time. This study aims to describe and examine newspaper coverage of HIV/AIDS in China from 2000 to 2010. A systematic search of the China Core Newspapers Database was conducted to identify HIV/AIDS-focused news articles; we found 3648 articles. Results show that coverage rates of HIV/AIDS in newspapers remained low, with only about three articles published per newspaper per year between 2000 and 2010. The sources focused primarily on prevention methods (23.7%), development of a cure or vaccine (21.2%), and education and awareness (17.2%). The HIV/AIDS-related topic covered in an article varied significantly depending on scope (national vs. local) of the newspaper (χ2=130.37, p<0.001) and article type (χ2=455.72, p<0.001). Totally, more articles were classified as positive than negative from 2002 to 2010. Findings indicate that the HIV/AIDS news-reporting pattern has shifted in the past decade, with more news stories disclosing information about prevention or treatment. However, coverage of HIV/AIDS remains insufficient. Enhancing collaboration between health educators and media sources can be an important strategy in disseminating HIV/AIDS knowledge.
Colonization of the Oral Cavity by Probiotic Bacteria

The aim of this study was to investigate if three probiotic bacteria present in the milk product Cultura Dofilus® naturell could be detected in saliva and on oral mucosal surfaces, and if they colonized dental surfaces in situ in 8 caries-inactive individuals after 8 daily exposures to the milk product for up to 3 days. Bacteria were identified by fluorescence in situ hybridization and confocal laser scanning microscopy. While probiotic bacteria were present sporadically in the oral cavity on mucosal surfaces and in saliva after 3 days of frequent use of the probiotic milk, they were not detected on dental surfaces. Probiotic bacteria may thus contribute to general oral health, but their potential role in biofilm-induced dental diseases remains unclear.
Exploring text datasets by visualizing relevant words

When working with a new dataset, it is important to first explore and familiarize oneself with it, before applying any advanced machine learning algorithms. However, to the best of our knowledge, no tools exist that quickly and reliably give insight into the contents of a selection of documents with respect to what distinguishes them from other documents belonging to different categories. In this paper we propose to extract `relevant words' from a collection of texts, which summarize the contents of documents belonging to a certain class (or discovered cluster in the case of unlabeled datasets), and visualize them in word clouds to allow for a survey of salient features at a glance. We compare three methods for extracting relevant words and demonstrate the usefulness of the resulting word clouds by providing an overview of the classes contained in a dataset of scientific publications as well as by discovering trending topics from recent New York Times article snippets.
Independent Expansion of Epitope-Specific Plasma Cell Responses upon HIV-1 Envelope Glycoprotein Immunization

Abs that bind the functional envelope glycoprotein (Env) spike are considered critical for a broadly effective prophylactic HIV-1 vaccine. The difficulty in eliciting such Abs by vaccination is partially attributed to the immunodominance of hydrophilic, surface-exposed variable protein regions of Env. However, little is known about the potential for competition between B cells that recognize distinct and distal epitopes on Env during protein subunit vaccination. In this study, we address this basic question at the level of Ab-secreting cells and serum IgG using a pair of isogenic soluble Env trimers, designated wildtype and gV3, which differ only in their potential to activate B cell responses against the highly immunogenic V3 region of Env. Immunization of mice with gV3 resulted in a markedly lower Ag-specific response compared with that induced by wildtype Env and could be explained by a loss of V3-directed reactivities. There was no redistribution of the response to other regions of Env in gV3-inoculated mice, suggesting that the epitope-specific Ab-secreting cell responses measured after boost are independently regulated rather than dictated by direct or indirect competition between B cells recognizing different structural elements of Env. This information is relevant for ongoing efforts in Env immunogen design to focus responses on conserved neutralizing determinants and for our general understanding of B cell responses to large-protein Ags that display numerous B cell epitopes.
Chronic coccydynia in adolescents. A series of 53 patients.

BACKGROUND Little is known about coccydynia in adolescents. AIM The aim of this study was to explore causes, clinical and imaging features and response to treatment of chronic coccydynia in adolescents. DESIGN This was a cohort study. SETTING The study included patients followed up at a specialized consultation in a university hospital. METHODS A series of 53 adolescent patients with chronic coccydynia were followed for 1-4 years. Investigations included dynamic X-ray films, with a magnetic resonance imaging scan of the coccyx in 26/53. Treatment was by coccygeal steroid injection or non-steroidal anti-inflammatory drugs (NSAIDs). Amitriptyline or coccygectomy were used as second-line treatment. Outcomes were assessed at a consultation two months after the treatment, then between one to four years later, by telephone interview, questionnaires and by a visual analogue scale (VAS). Fifty-one adult patients with coccydynia formed the control group. RESULTS In 20 cases (37.7%) the coccydynia was subsequent to trauma. Obesity was not a risk factor. Abnormal mobility was rarer and spicules more frequent compared to adult patients (P<0.001); 11/27 MRI scans showed a hypersignal within the disc or adjacent bone and 6/27 a hypersignal surrounding the tip of the coccyx (bursitis). Initial treatment was a coccygeal steroid injection for 41 patients and NSAIDs for 12. Ten were given amitriptyline and 3 a coccygectomy. At final assessment, there was no pain or almost no pain in 32/53 (60.4%), moderate pain and functional impairment in 12/53 (22.6%) and severe pain and functional impairment in 9/53 (17%). CONCLUSION Coccydynia in adolescents differs from coccydynia in adults. A MRI scan is helpful and should be obligatory for diagnosis. Prognosis is relatively good. CLINICAL REHABILITATION IMPACT Our results should help clinicians manage this rare and debilitating condition.
Prediction of Explosion Limits of Multi-Component Gas Mixture Using LS-SVR

In safety engineering, lower and upper explosion limits are the important indices to evaluate the safety of multi-component explosive gas mixture such as hydrogen and methane. There is a nonlinear dependence of explosion limits on the composition (components and theirs concentration) of multi-component explosive gas mixture. Therefore, a least square support vector regression (LS-SVR) model was proposed to establish a non-linear model between the composition of the explosive mixture and the explosion limits. The results show that the LS-SVR model predicted explosion limits with good accuracy. The selection of input variables for the LS-SVR showed significant effect on the predictive accuracy.
Mortality and Recovery of Hemlock Woolly Adelgid (Adelges tsugae) in Response to Winter Temperatures and Predictions for the Future

Eastern (Tsuga canadensis) and Carolina hemlocks (T. caroliniana) of eastern North America have been attacked by the non-native hemlock woolly adelgid (Adelges tsugae Annand) (HWA) since the first half of the 20th century. Unlike most insects, HWA develops through one generation from fall to late winter, exposing this insect to the lethal effects of winter temperatures. The mortality inflicted by winter temperatures on HWA determines the surviving population density as well as its ability to spread to uninfested areas. With the ongoing changes in climate, knowledge of this species’ ability to survive and spread in the future can help land managers prepare for its management. This study began during the winter of 2014 and ended in the spring of 2017. During this period, winter mortality of HWA was recorded at 100 sites from Maine to Georgia (n = 209). Changes in population density from the sistens to the succeeding progrediens generation were recorded at 24 sites (n = 35). Models were developed to predict HWA mortality using the lowest minimum temperature prior to the mortality assessment date, the number of days with mean temperature <−1 °C, and the mean daily temperature of the three days preceding that minimum. Models were also developed to predict population density changes from the overwintering sistens generation to the following progrediens generation. Future projections under climate change showed increases in winter survival and population growth rates over time. Especially towards the northeastern edge of T. canadensis’ distribution as minimum temperatures are predicted to increase at a greater rate. This will result in an increase in density throughout its current distribution and expansion northward causing an increase in its impact on eastern Tsuga spp.
Focus: Querying Large Video Datasets with Low Latency and Low Cost

Large volumes of videos are continuously recorded from cameras deployed for traffic control and surveillance with the goal of answering "after the fact" queries: identify video frames with objects of certain classes (cars, bags) from many days of recorded video. While advancements in convolutional neural networks (CNNs) have enabled answering such queries with high accuracy, they are too expensive and slow. We build Focus, a system for low-latency and low-cost querying on large video datasets. Focus uses cheap ingestion techniques to index the videos by the objects occurring in them. At ingest-time, it uses compression and video-specific specialization of CNNs. Focus handles the lower accuracy of the cheap CNNs by judiciously leveraging expensive CNNs at query-time. To reduce query time latency, we cluster similar objects and hence avoid redundant processing. Using experiments on video streams from traffic, surveillance and news channels, we see that Focus uses 58X fewer GPU cycles than running expensive ingest processors and is 37X faster than processing all the video at query time.
Adenosine Stimulates Anion Secretion Across Cultured and Native Adult Human Vas Deferens Epithelia1

Abstract Experiments were conducted to determine the responsiveness of human vas deferens epithelial cell monolayers to adenosine and related agonists. Human abdominal vas deferens epithelial cells have been isolated from adult tissues and grown to confluence on permeable supports. All cells exhibit intense ZO-1 and cytokeratin immunoreactivity. Cultured cell monolayers exhibit high electrical resistance with a lumen-negative potential difference and short circuit current (Isc) indicative of anion secretion and/or cation absorption. A portion of the basal Isc is inhibited by amiloride. Amiloride-sensitive Isc is enhanced by exposure to glucocorticoids and is Na+ dependent, indicating the presence of epithelial sodium channel-mediated Na+ absorption. Epithelial anion secretion and intracellular generation of cAMP are acutely stimulated by adenosine and the adenosine receptor agonist 5′-(N-ethylcarboxamido)adenosine (NECA), with these effects being fully blocked by 8-phenyltheophylline. Adenosine receptors are localized to the apical membrane of the epithelial cells, as basolateral adenosine is without effect. Freshly excised human vas deferens recapitulate observations made on cultured epithelia when evaluated with the self-referencing vibrating probe: amiloride inhibition of basal ion transport, stimulation by adenosine, and inhibition by 8-phenyltheophyline. These results demonstrate that adult human vas deferens epithelium actively transports ions to generate the luminal environment of the deferent duct. Thus, vas deferens epithelium likely plays an active role in male fertility, and interventions that modulate epithelial function might be exploited to treat male-factor infertility or in contraception.