Miracle-dz/UniFAR-FTUs huggingface dataset:
Cognitive dysfunction in HIV patients despite long-standing suppression of viremia

Objective:To determine the prevalence of cognitive complaints and HIV-associated neurocognitive disorders (HANDs) in a cohort of aviremic HIV-positive patients. To evaluate the relevance of the HIV dementia scale to detect HANDs. Design:Assessment of HANDs with neuropsychological tests. Methods:Two hundred HIV-infected patients with undetectable HIV-1 RNA concentrations in the plasma, no history of major opportunistic infection of the central nervous system in the past 3 years, no current use of intravenous drugs, and no major depression answered a questionnaire designed to elicit cognitive complaints. Cognitive functions of 50 complaining and 50 noncomplaining HIV-positive patients were assessed. Results:Patients had undetectable HIV-1 RNA concentrations for a median time of 48 months (range 3.2–136.6). The prevalence of cognitive complaints was 27%. The prevalence of HANDs was 84% among patients with cognitive complaints (asymptomatic neurocognitive impairment 24%, mild neurocognitive disorders 52%, and HIV-associated dementia 8%) and 64% among noncomplainers (asymptomatic neurocognitive impairment 60%, mild neurocognitive disorders 4%, and HIV-associated dementia 0%; P < 0.001). A score of 14 points or less on the HIV dementia scale yielded a positive predictive value of HANDs of 92% in complainers and 82% in noncomplainers. Conclusion:The prevalence of HANDs is high even in long-standing aviremic HIV-positive patients. However, HANDs without functional repercussion in daily life (asymptomatic neurocognitive impairment) is the most frequent subtype observed. In this population, the HIV dementia scale with a cutoff of 14 points or less seems to provide a useful tool to screen for the presence of HANDs.
How the disposition effect may explain momentum: the relationship between investment behavior biases and brazilian market movements

Momentum is one of the most robust anomalies in financial markets, there are two main recent explanations for this phenomenon, a behavioral-based explanation through disposition-effect (i.e., the willingness to sell “winners” too quickly and to hold “losers” for a long time) and a fund-flow based explanation. The disposition-effect explanation is centered in the convergence of the spread between the fundamental value and the observed market price (disposition-effect causes an underreaction to news that generates this spread), and the fund flows-based explanation is due to the persistence of the performance of mutual-funds (which usually keep buying winning positions and selling the losses). This master thesis compares those theories using Brazilian data (which is suitable for the strong presence of momentum). Our empirical analysis was done using Fama-MacBeth regressions with results pointing the disposition-effect explanation as the most significant, with our robustness analysis contributing positively to the main findings.
EFFECTS OF THE COMPETITOR ON ANTIBODY-HAPTEN BINDING IN IMMUNOASSAYS

ABSTRACT The effects of competitors on antibody (Ab)-hapten binding in an immunoassay were investigated using a goat anti-methamphetamine (MA) antibody (Ab). An N-4-aminobutyl derivative of methamphetamine (4-ABMA) was conjugated with keyhole limpet hemocyanine (KLH) and used as an immunogen. The antiserum was purified by affinity chromatography with various ligands, including 4-ABMA-protein conjugates, free haptens, and protein G. Direct and indirect competitive enzyme-linked immunosorbent assays (ELISA) were conducted with a competitor of 4-ABMA-fluorescein isothiocyanate (4-ABMA-FITC). The results were compared to those of ELISA with a different competing antigen, 4-ABMA-ovalbumin (4-ABMA-OVA), in terms of sensitivity and specificity. In both direct and indirect assay formats, the sensitivity was much improved with 4-ABMA-FITC, compared to that with 4-ABMA-OVA, suggesting that different labels on the same haptenic moiety for competitors considerably influence the assay performance. All the purified Abs also showed a distinct feature of strong affinity for benzphetamine with 4-ABMA-FITC, whereas they had their respective binding specificities with 4-ABMA-OVA. Comparing the results to those from other assay systems, we determined that the assay sensitivity was dependent on both the system and the competitor employed, and that the specificity was primarily dependent on the competitor used.
Structure and Intermolecular Interactions of the Luminal Dimerization Domain of Human IRE1α*

Accumulation of unfolded proteins in the lumen of the endoplasmic reticulum activates a signal transduction cascade that culminates in the transcriptional induction of genes encoding adaptive functions. One proximal sensor for this unfolded protein response is the protein kinase/endoribonuclease IRE1α. IRE1α is a type-I transmembrane glycoprotein for which the N-terminal luminal domain (NLD) senses the accumulation of unfolded proteins. Previously we demonstrated that the NLD forms a stable ligand-independent dimer linked by disulfide bridges. In this report we have identified the cysteine residues responsible for intermolecular disulfide bonding. However, this covalent interaction was not required for dimerization and/or signaling, suggesting that a cryptic dimer interface exists in the NLD that is independent of covalent disulfide interactions. Limited proteolysis of the NLD revealed characteristic fragments, all retaining the same N-terminal sequences as full-length NLD. Biochemical and functional studies using NLD truncation mutants indicated that the dimerization domain of the NLD is confined to the conserved motifs at the N-terminal regions where putative hydrophobic interactions exist. In addition, the peptide binding domain of the endoplasmic reticulum protein chaperone BiP interacted with the N-terminal region within the NLD. Our findings suggest that the NLD has at least two distinct types of interactions mediating dimerization and function in signaling,i.e. covalent interactions involving disulfide bond formation and hydrophobic interactions, with the hydrophobic interaction being the driving force for dimerization.
Influence Estimation and Opinion-Tracking Over Online Social Networks

This article presents a restricted maximum likelihood-based algorithm to estimate who influences whose opinions and to what degree when agents share their opinions over large online social networks such as Twitter. The proposed algorithm uses multi-core processing and distributed computing to provide a scalable solution as the optimization problems are large in scale; a network with 10,000 agents and average connectivity of 100 requires estimates of about 1 million parameters. A computational study is then used to show that the estimates are efficient and robust when the full rank conditions for the covariance matrix are met. The results also highlight the importance of the quantity of the information being shared over the social network for the inference of the influence structure.
Reaction Time and Attention

This pilot study shows results of an experiment comparing reaction times (RTs) and attentional performance between an ADHD group of 30 children and 30 controls, both Spanish speaking. The experiment was carried out using the Seville computerized neuropsychological battery (SNB). Objective: This study had two goals: One was to test sensitivity of SNB for attention deficits in ADHD and the second was to detect differences in RTs between ADHD and controls. Possible explanations and implications of such differences are also discussed. Method: SNB computerized system was used to assess RTs and accuracy, and alternate forms of continuous performance task were used. Results: Results showed high sensitivity of some of the SNB tests, especially cancellation tests. RTs were significantly different between groups. Conclusion: SNB represents a helpful tool for detection of attention deficits, and RT indices represent the most significant variable in differentiation of both groups studied.
A sensitive and selective liquid chromatography-tandem mass spectrometry method for simultaneous determination of five isoquinoline alkaloids from Chelidonium majus L. in rat plasma and its application to a pharmacokinetic study.

Chelidonium majus L. is one of the most important medicinal plants of the family Papaveraceae. Its pharmacological effects have been primarily attributed to the presence of a number of alkaloids. In the present study, a sensitive and selective liquid chromatography-tandem mass spectrometry method for simultaneous determination of five isoquinoline alkaloids from Chelidonium majus L. was developed and validated. The analytes (protopine, chelidonine, coptisine, sanguinarine and chelerythrine), together with the internal standard (palmatine), were extracted from acidified rat plasma with ethyl acetate-dichloromethane (4:1, v/v). Chromatographic separation was carried out on a Diamonsil C(18) column with an isocratic mobile phase consisting of acetonitrile and water (adjusted to pH 2.3 with formic acid) (30:70, v/v) at a flow rate of 0.4 ml/min. Mass spectrometric detection was performed by selected reaction monitoring mode via electrospray ionization source operating in positive ionization mode. The assay exhibited good linearity (r ≥ 0.9933) for all the analytes. The lower limits of quantification were 0.197-1.27 ng/ml using only 50 µl of plasma sample. The intra- and inter-day precisions were less than 11.9%, and the accuracy was between -6.3% and 9.3%. The method was successfully applied to the pharmacokinetic study of the five alkaloids in rats after intragastric administration of Chelidonium majus L. extract.
Psychosocial Work Environment and Intention to Leave the Nursing Profession: A Cross-National Prospective Study of Eight Countries

Many countries throughout the world are facing a serious nursing shortage, and retention of nurses also is a challenge. The aim of this study was to compare the predictive contribution of a broad spectrum of psychosocial work factors, including job strain, effort-reward imbalance, and alternative employment opportunity, to the probability of intention to leave the nursing profession. A total of 7,990 registered female nurses working in hospitals in eight countries (Germany, Italy, France, the Netherlands, Belgium, Poland, Slovakia, and China) were included in the one-year prospective study. A standardized questionnaire on job strain, effort-reward imbalance, employment opportunity, and intention to leave the nursing profession was used in the survey. Multilevel logistic regression modeling was used to analyze the data. Results showed that an imbalance between high effort and low reward (in particular, poor promotion prospects) and good employment opportunity at baseline were independently associated with a new intention to leave the nursing profession at follow-up. However, job strain appeared to have relatively less explanatory power. Findings suggest that interventions to improve the psychosocial work environment, especially the reciprocity experienced between effort and reward, may be effective in improving retention of nurses and tackling the international nursing shortage.
What effect does inequality have on residents’ sense of safety? Exploring the mediating processes of social capital and civic engagement

ABSTRACT A sense of safety and security is of the utmost importance for most residents because it contributes to personal and collective well-being. However, that sense of safety may rest upon community structural factors such as inequality and intracommunity factors such as social capital and civic engagement. In fact, these factors may mediate the relationship between inequality and residents’ sense of safety. As such, the purpose of this study is to investigate this process—the extent to which social capital and civic engagement partially mediate the relationship between economic inequality and sense of safety across 26 U.S. metro areas. Using structural equation modeling (SEM), we found that social capital fully mediates the relationship between inequality and sense of safety but that civic engagement does not. Specifically, residents in communities characterized by high levels of inequality also report reduced levels of social capital, which then results in a lower sense of safety. Additionally, residents who report lower civic engagement report that their communities are less safe.
„Missed” Upper Gastrointestinal Tract Lesions May Explain „Occult” Bleeding

BACKGROUND AND STUDY AIMS Enteroscopy has been shown to be an effective diagnostic method in patients with obscure gastrointestinal bleeding. Arteriovenous malformations (AVMs) of the small bowel are the most common lesions discovered at enteroscopy. However, bleeding lesions may still be detected in the upper gastrointestinal tract even in patients who have previously undergone esophagogastroduodenoscopy. The aim of this study was to focus on these "missed" upper gastrointestinal lesions. PATIENTS AND METHODS A retrospective review was conducted of all enteroscopic examinations carried out in patients with suspected gastrointestinal bleeding or overt gastrointestinal bleeding treated at our institution between 1993 and 1997. All patients had previously undergone an esophagogastroduodenoscopy. The push enteroscope (Olympus XSIF-100) was used in all of them. RESULTS Push enteroscopy was performed in 233 patients (124 men and 109 women; mean age 63). A suspected bleeding lesion was observed in 53 % of the cases. AVMs represented 63% of the detected lesions. "Missed" upper gastrointestinal lesions were described in 25 patients (10.2 %). In half of these cases, the lesion was located in the upper part of the fundus. Wirsungorrhagia was the cause of bleeding in two cases. CONCLUSIONS The study confirmed that push enteroscopy is an effective method of detecting lesions responsible for occult gastrointestinal bleeding. In this study, the overall diagnostic yield was 53%. In 10% of the patients, the lesion was located in the upper gastrointestinal tract, despite an initial esophagogastroduodenoscopy. The lesions were mainly located in the fundus. Although it is a rare condition, Wirsungorrhagia must be considered in patients with occult gastrointestinal bleeding.
Expression of apoptosis in placentae from mice lacking the prostaglandin F receptor.

This study aimed to investigate the changes in apoptosis in the placenta and decidua of pregnant mice lacking the prostaglandin F receptor. Mouse placentae were removed from fetuses on days 10-23 of pregnancy. Apoptotic cells were examined by a DNA fragmentation assay and the terminal deoxynucleotidyl transferase-mediated dUDP nick end-labelling (TUNEL) technique. The placenta and decidual weight increased before day 18 and 14 of pregnancy, and then decreased with gestational day. After day 19, the fetuses gradually died in the uterus. All fetuses died in the uterus on day 23 of pregnancy. The number of apoptosis was not significantly different between wild type and FP-deficient mice before day 18 of pregnancy by DNA fragmentation and TUNEL staining. The DNA fragmentation was always more pronounced in decidual tissue on each day of pregnancy. DNA laddering on placentae was more extensive on day 22 than day 18. In placenta, most TUNEL-positive cells were detected in trophoblast and stromal cells. A higher intensity of apoptotic cells was in the decidual basalis. The main area was the centre of the decidual basalis, and was in decrease toward to margin of placenta. The index of TUNEL positive cells increased as gestation progressed toward termination. Especially, it was prominent in the placentae on day 22 compared with that day 18 of pregnancy. The increased TUNEL-positive staining in syncytiotrophoblast surface was found in placenta at post-term, compared with those at term. Apoptosis may provide insights into both normal placental development and placental dysfunction during an abnormal pregnancy from post-term pregnancy.
Measurement of localized muscle fatigue in building work.

The loads on the shoulder muscles of building workers were investigated by applying a new fatigue index method, for evaluation of localized muscle fatigue during work. Based on a power spectrum analysis of myoelectric signals, and calculations of spectral moments, the method enables the monitoring of changes in the propagation velocity of muscle fibre action potentials. The propagation velocity alters with the integrated response to the strain of the load on muscle metabolism and circulation Myoelectric signals from four shoulder muscles as well as the ECG were recorded on magnetic tape at the building sites during regular daily work. For analysis, specially developed computerized procedures were used, including procedures for automatic checks of signal quality Significant localized muscle fatigue was found in one or more muscles during a spell of work. The fatigue was particularly marked in the supraspinatus and trapezius muscles, and was seen in static work tasks even when the force exerted was small. T.
A price target for U.S. monetary policy? Lessons from the experience with money growth targets

The cutting edge of recent efforts to reshape monetary policy in many countries has been to impose a price target on the central bank. This paper examines such a policy in light of the Federal Reserve System's experience with money targeting from the late 1970s through the mid 1980s. The empirical analysis documents the Federal Reserve's initial use and subsequent disregard of money growth targets, and shows that abandoning these targets was a sensible response to the changing mix of shocks affecting the U.S. economy -- specifically, an increase in the relative volatility of money demand shocks. This experience provides little ground for confidence that a price target would be optimal for U.S. monetary policy. Even if the structure of the relevant shocks at any particular time were to appear favorable, a policy based on a price target would likewise be undermined if the relative volatility of aggregate supply shocks increased.
Interactions between Exogenous Auditory and Visual Spatial Attention

Six experiments were carried out to investigate the issue of cross-modality between exogenous auditory and visual spatial attention employing Posner's cueing paradigm in detection, localization, and discrimination tasks. Results indicated cueing in detection tasks with visual or auditory cues and visual targets but not with auditory targets (Experiment 1). In the localization tasks, cueing was found with both visual and auditory targets. Inhibition of return was apparent only in the within-modality conditions (Experiment 2). This suggests that it is important whether the attention system is activated directly (within a modality) or indirectly (between modalities). Increasing the cue validity from 50% to 80% influenced performance only in the localization task (Experiment 4). These findings are interpreted as being indicative for modality-specific but interacting attention mechanisms. The results of Experiments 5 and 6 (up/down discrimination tasks) also show cross-modal cueing but not with visual cues and auditory targets. Furthermore, there was no inhibition of return in any condition. This suggests that some cueing effects might be task dependent.
The impact of paternity on male–infant association in a primate with low paternity certainty

In multimale groups where females mate promiscuously, male–infant associations have rarely been studied. However, recent studies have shown that males selectively support their offspring during agonistic conflicts with other juveniles and that father's presence accelerates offspring maturation. Furthermore, it was shown that males invest in unrelated infants to enhance future mating success with the infant's mother. Hence, infant care might provide fitness gain for males. Here, we investigate male–infant associations in rhesus macaques (Macaca mulatta), a primate with low paternity certainty as females mate with multiple partners and males ensure paternity less efficiently through mate‐guarding. We combined behavioural data with genetic paternity analyses of one cohort of the semi‐free‐ranging population of Cayo Santiago (Puerto Rico) and recorded affiliative and aggressive interactions between focal subjects and adult males from birth to sexual maturation (0–4 years) of focal subjects. Our results revealed that 9.6% of all interactions of focal subjects involved an adult male and 94% of all male–infant interactions were affiliative, indicating the rareness of male–infant aggression. Second and most interestingly, sires were more likely to affiliate with their offspring than nonsires with unrelated infants. This preference was independent of mother's proximity and emphasized during early infancy. Male–infant affiliation rose with infant age and was pronounced between adult males and male rather than female focal subjects. Overall, our results suggest that male–infant affiliation is also an important component in structuring primate societies and affiliation directed towards own offspring presumably represent low‐cost paternal care.
Mid-Ocean Ridges: Discontinuities, Segments and Giant Cracks

Geological observations reveal that mid-ocean ridges are segmented by numerous rigid and nonrigid discontinuities. A hierarchy of segmentation, ranging from large, long-lived segments to others that are small, migratory, and transient, determines the pattern and timing of creation of new ocean floor. To the extent that spreading segments behave like giant cracks in a plate, the crack propagation force at segment tips increases with segment length, which may explain why long segments tend to lengthen and prevail over shorter neighboring segments. Partial melting caused by decompression of the upper mantle due to plate separation and changes in the direction of spreading result in the spawning of new short segments so that a balance of long and short segments is maintained.
Care dependence and activities of daily living in relation to ageing: results of a longitudinal study.

From 1990 to 1993, the University of Limburg and the Pepijn Centre, the Netherlands, have performed a prospective cohort study on ageing and intellectual disability. The key questions of the study were: "To what degree do the level of care dependence and activities of daily living (ADL) differ between age groups, and to what degree do these skills change during the study period (3 years)? Are the changes age related? '. Looking at the changes in time, the results show that the level of care dependence did not change substantially in the sample of 1602 residents of Dutch facilities for people with intellectual disability. Only the oldest residents (70+ years) showed a significant decline in independence. The results also show that the skills of young people with Down's syndrome (< 40 years) did not change substantially, whereas older people with Down's syndrome (40+ years) showed a substantial decrease in ADL-skills. The ADL-skills of the residents with other aetiological diagnoses younger than 60 years of age did not change substantially, while the older residents (60-69 and 70+ years) showed a significant decrease in ADL-functions. The trend between changes in ADL and age in both aetiological groups was statistically significant. Attention is paid to the implications of these findings in the discussion.