Miracle-dz/UniFAR-FTUs huggingface dataset:
No Difference in Emergence Time and Early Cognitive Function Between Sevoflurane-Fentanyl and Propofol-Remifentanil in Patients Undergoing Craniotomy for Supratentorial Intracranial Surgery

Balanced anesthesia with sevoflurane-fentanyl has been widely accepted as anesthetic management for neurosurgery. Propofol-remifentanil regimen has been successfully used in various surgical settings, but a comprehensive comparison of sevoflurane-fentanyl and propofol-remifentanil anesthesia in patients undergoing craniotomy for supratentorial intracranial surgery has not yet been done. The aim of this prospective, randomized, open-label clinical trial was to compare clinical properties of sevoflurane-fentanyl with propofol-remifentanil anesthesia in patients undergoing supratentorial intracranial surgery. The primary endpoint was to compare early postoperative recovery and cognitive functions within the two groups; we also evaluated hemodynamic events, vomiting, shivering, and pain. One hundred twenty patients (64 males; age 15-75 years) were randomized to either total intravenous anesthesia (group T) or sevoflurane anesthesia (group S). Emergence and extubation times and cognitive function (Short Orientation Memory Concentration Test [SOMCT]) were compared in the two groups. Brain swelling, incidence of hypotensive and hypertensive episodes, postoperative vomiting, shivering, and pain were also analyzed. The mean emergence time (12.2 ± 4.9 minutes for group S versus 12.3 ± 6.1 minutes for group T; P = 0.92) and extubation time (18.2 ± 2.3 minutes for group S versus 18.3 ± 2.1 minutes for group T; P = 0.80) were similar in the two groups. Average SOMCT scores, both 15 minutes after extubation (25.6 ± 4.9 in group S versus 23.9 ± 7.5 in group T; P = 0.14) and 45 minutes after extubation (27.3 ± 2.2 in group S versus 26.0 ± 5.1 in group T; P = 0.07) were also comparable. Brain swelling was present in seven and five patients in groups S and T, respectively (P = 0.76). Hypotension was present in 12% (group S) and 28% (group T) of patients (P = 0.02). Hypertension was present in 17% of patients in group S and 40% of patients in group T (P = 0.0046). Shivering was present in 18% and 25% of patients in groups T and S (P = 0.37). Our study demonstrates that there is no patient benefit of using total intravenous anesthesia with an ultra-short-acting opioid over the conventional balanced volatile technique in terms of recovery and cognitive functions.
A possible association between preterm birth and early periodontitis. A pilot study.

UNLABELLED According to many studies, generalised periodontitis can be a risk factor for preterm birth (PB). A case-control study was carried out to examine if early localised periodontitis could be a risk factor for adverse pregnancy outcome. MATERIAL AND METHODS Postpartum women without any systemic disease were included into the study. Similar numbers of patients belonged to the case (41) and to the control (44) groups. A PB case was defined if a patient had a threatening premature labour during pregnancy, preterm premature rupture of membranes, or spontaneous preterm labour, and/or the weight of the newborn was < or = 2499 g. Control women had delivery after the 37th gestational week and the newborn's weight was > or = 2500 g. Known risk factors like smoking, alcohol, drug consumption, socio-economic status and the periodontal status were recorded. RESULTS A significant association was found between PB and early localised periodontitis of the patient with the following criterion having bleeding at > or = 50% of the examined sites (6 at each tooth) and having at least at one site > or = 4 mm probing depth (p = 0.001). The odds ratio was 5.46 at the 95% confidence interval. The average weight of the newborns in the periodontitis group was less than in the control group, the difference is significant (p = 0.047). CONCLUSION The results indicate that early localised periodontitis of the patient during pregnancy can be regarded as an important risk factor for PB.
Cardiovascular MRI Predicts 5‐Year Adverse Clinical Outcome in Heart Transplant Recipients

Imaging recommendations for the follow‐up of heart transplant recipients (HTRs) lack evidence justifying their prognostic value. Cardiovascular magnetic resonance imaging (CMRI) can characterize heart structure and function and has prognostic value in many myocardial diseases. We hypothesized that CMRI evaluation of cardiac allografts would predict adverse events. We performed CMRI on 60 HTRs evaluating biventricular size, function and myocardial scar. We performed survival analysis to identify independent predictors of cardiovascular (CV) death or hospitalization. Participants had a mean age of 51 ± 14 years, mean graft age of 3.5 years (±4) and 75% are male. Median follow‐up time was 4.9 years with 22 CV hospitalizations and 7 CV deaths. A multivariable survival analysis of imaging and clinical variables identified myocardial scar (hazard ratio [HR] of 10.7, p = 0.005), right ventricular end‐ diastolic volume index (RVEDVI; 1.1/mL/m2, p = 0.001), graft age (HR = 1.2/year, p = 0.004) and previous allograft rejection (HR = 4.4, p = 0.006) as predictive of time to CV death or hospitalization. CMRI‐derived myocardial scar and RVEDVI are independently associated with CV outcomes in HTRs.
Phytotoxicity and antioxidative enzymes of green microalga (Desmodesmus subspicatus) and duckweed (Lemna minor) exposed to herbicides MCPA, chloridazon and their mixtures

In this study, we evaluate the toxicity of MCPA (auxin-like growth inhibitor), chloridazon (CHD) (PSII-inhibitor) and their mixtures to floating plants and planktonic algae. Toxicity of MCPA (4-chloro-2-methylphenoxyacetic acid) and CHD (5-amino-4-chloro-2-phenyl-3(2H)-pyridazinone) was first assessed in two growth inhibition tests with Lemna minor (ISO/DIS 20079) and Desmodesmus subspicatus (ISO 8692). Next, herbicide mixtures at concentrations corresponding to the EC values were used to assess their interactive effects, and the biomarkers were: for duckweed fresh weight, frond area, chlorophyll content and number of fronds, and for algae cell count and cell volume. The 3d EC10 and EC50 values using cell counts of D. subspicatus were 142.7 and 529.1 mg/L for MCPA and 1.7 and 5.1 mg/L for CHD. The 7d EC10 and EC50 values using frond number of L. minor amounted to 0.8 and 5.4 mg/L for MCPA and 0.7 and 10.4 mg/L for CHD. Higher sensitivity of reproductive (number of cells/fronds) than growth processes (cell volume/frond area) to herbicides applied individually and in mixtures was especially pronounced in the responses of Desmodesmus. Herbicide interactions were assessed by the two-way ANOVA and Abbott's formula. Generally, an antagonistic interaction with Lemna was revealed by MCPA and chloridazon, whereas additive effect of both herbicides was observed for Desmodesmus. A significant stimulation of SOD and APX activity by binary mixtures was noted in algal cells mainly after 24 and 48 hours of exposure. The extremely high stimulation of the activity of both enzymes was induced by the combination EC10CHD + EC50MCPA (48 h). Presumably due to oxidative stress, the treatment with CHD at concentration EC50 after 72h was lethal for algae grown in aerated cultures, in contrast to standardized test conditions. Taking into account the consequences of risk assessment for herbicide mixtures we can state that a relatively low toxicity, as well as the lack of significant synergy between MCPA and CHD to non-target plants appears to be the most important result.
Molecular Characterization of Aquatic Bacterial Communities in Dinaric Range Caves

Dinaric limestone cave systems, recognized as a hotspot of subterranean biodiversity, inhabit composite microbial communities whose structure, function and importance to ecosystems was poorly considered until the last few years. Filamentous microbial biofilms from three caves in Dinaric karst were assessed using 16S rRNA‐based phylogenetic approach combined with universally protein coding genes/proteins. Studied clone libraries shared divisions but phylogenetic distribution of the obtained phylotypes differed: in Veternica and Vjetrenica clone libraries, Nitrospirae prevailed with 36% and 60% respectively, while in Izvor Bistrac the most abundant were Alphaproteobacteria (41%) followed by Firmicutes (32%). Moreover, three phylotypes were associated with novel uncultured candidate divisions OP3, WS5 and OD1 revealing the diversity and uniqueness of the microbial world in caves. Deeply understanding subterranean habitats could elucidate many new aspects in phylogeny and evolution of microorganisms as well as animal taxa, adjacent to their energy suppliers in microbial communities and biofilms.
No . 464 INNOVATION STRATEGIES , EXTERNAL KNOWLEDGE AND PRODUCTIVITY GROWTH

This paper studies firms’ capability to recombine internal and local knowledge. It measures the outcome in terms of total productivity growth. Using Swedish data on commuting time for face-to-face contacts across all 290 municipalities, we employ a time sensitive approach for calculating localized knowledge within a municipality and and its close neighbors. Internal knowledge is captured by register data on firms’ innovation intensity. The two sources of knowledge are modeled in a production function setting by discrete composite variables with different combinations of input factors. Applying the model on Swedish firm level panel data, we find strong evidence of differences in the capacity to benefit from external knowledge among persistent innovators, temporary innovators and non-innovators. The results are consistent regardless of whether innovation efforts are measured in terms of the frequency of patent applications or the level of R&D investment.
A Social Commerce Intention Model for Traditional E-Commerce Sites

The existing literature mainly analyses user intention to practice social commerce on social networking sites, but few studies have focused on traditional e-commerce sites with their own integrated social tools (e.g. forums, reviews). This research aims to identify the antecedents to social commerce intention for traditional e-commerce sites where social tools are integrated. Data were obtained from a survey of 201 consumers and were analysed using Partial Least Squares. The results indicate that web quality, flow and emotional social support have a positive and direct influence on social commerce intention, while social presence and informational social support are not significant. This study contributes to consumer behaviour theory by applying predictors of intention to social commerce for traditional e-commerce sites. The results also help e-commerce practitioners to improve their use of social tools. For instance, to increase the use of social commerce, web quality must be improved to promote dissemination and consultation of the information generated by users in an easy, quick and friendly way. Social commerce intention will also increase if the company designs efficient interactive processes which the user enjoys effortlessly, so that the website creates a flow experience.
Affective Technology Acceptance Model: Extending Technology Acceptance Model with Positive and Negative Affect

Research works on TAM, TAM2, TAM3 and UTAUT has always focused on cognitive aspect of technology acceptance in the past two decades. Acceptance of technologies such as eCommerce, Mobile and ERP that considered emotion and affect are still less. This creates a gap in the technology acceptance research, which consider the role of affect into technology acceptance model. This study considers the role of affect of a knowledge worker that work in Multimedia Super Corridor (MSC)-status organizations in Malaysia on their behavioural intention to use knowledge sharing tools (KS tools) in their day-to-day tasks. Hence, Affective Technology Acceptance (A.T.A) model has been proposed. The behavioural intention on the acceptance of KS tools will be hypothesize in the Affective Technology Acceptance (A.T.A) model. Positive (PA) and Negative (NA) affect as the role of affect construct were introduce in this model to investigate its influence on KS tools usefulness and ease of use among employees in Multimedia Super Corridor organizations. The findings of this study highlighted that NA has no impact on perceive usefulness. The findings also showed that PA has very significant positive influence on PU, PEOU and BI with impact on PEOU being the greatest.
3 Rhetoric Versus Reality Why Ethics Training Fails — and How to Fix It

B police Chief Michael Meehan was already under intense scrutiny when the Oakland Tribune featured a story involving his use of department resources to locate his son’s missing iPhone (Bender, 2012). The incident began on January 11, 2012, when Meehan’s son, a freshman at Berkeley High School, found that his iPhone, equipped with the Find My iPhone tracking software, was missing from his unlocked gym locker. The boy alerted his father, and Meehan pulled out his own cell phone and showed a property crimes detective sergeant the real-time movement of the stolen phone. Given the active signal of the stolen phone, the detective sergeant took his team to try to locate it. As the signal was moving into the city of Oakland, the detective sergeant called the drug task force to ask for some additional assistance, said Sgt. Mary Kusmiss, a department spokeswoman. However, a police report about the theft of the iPhone was never written, and the Oakland Police Department was never notified that officers on the department’s drug task force were in North Oakland knocking on doors looking for the phone. Three detectives and a sergeant each logged two hours of overtime. Controversy over the search comes at a time when the city is spending $20,000 to make sure its police department’s media policies are up to speed 3 Rhetoric Versus Reality
A Transpersonal Approach to Care

The arts have a history of relaxing and calming patients in the hospital setting, yet research is limited on how arts may aid in the healing process. DooR to DooR was established to bring comfort, respite, and healing to hospitalized patients, family members, and health care staff. DooR to DooR is located in the University of North Carolina Hospitals at Chapel Hill, North Carolina; professional performing artists visit there, spending 5 to 10 minutes with each patient, family member, and health care staff. The purpose of this qualitative study is to understand performers’ experiences and of how arts-based programs can facilitate improved patient outcomes in the hospitalized setting to help nurses better use the arts in their care of patients and families. Three overarching themes were identified: (a) the arts are therapeutic for all involved, (b) the arts transforms the hospital environment, and (c) nurses and the other medical staff play an important role. The significance of this study for nursing practice is that the arts are a plausible intervention for the hospital because they may help improve patient outcomes by reducing pain and depression and by relieving stress among staff and family members. More research is needed to determine the level of arts-as-an-intervention knowledge among nurses.
In Vitro Activity of Hepatitis C Virus Protease NS3 Purified from Recombinant Baculovirus-infected Sf9 Cells (*)

A recombinant Baculovirus expression system was used for the production of a 20-kDa protein encompassing the hepatitis C virus NS3 protease domain. The protein was purified to apparent homogeneity after detergent extraction of cell homogenates. It was shown to be a monomer in solution and to cleave the in vitro translated precursor proteins NS4A-NS4B and NS5A-NS5B, but not the NS4B-NS5A or the NS3-NS4A precursors. The enzyme also cleaved a 20-mer peptide corresponding to the NS4A-NS4B junction with k/K = 174 M s. Peptides harboring NS4A sequences comprising amino acids 21-54 (Pep4A) and 21-34 (Pep4A) were found to induce an up to 2.8-fold acceleration of cleavage. Kinetic analysis revealed that this acceleration was due to an increase in k, whereas no significant effect on K could be detected. Pep4A was also an absolute requirement for cleavage of in vitro translated NS4B-NS5A by the purified protease. From these data we conclude that: (i) the purified protease domain shows substrate specificity and cleavage requirements similar to those previously reported on the basis of transfection experiments, (ii) activation of the purified protease by the NS4A co-factor can be mimicked by synthetic peptide analogs, and (iii) a central hydrophobic region of NS4A with a minimum core of 14 amino acids is responsible for the interaction with NS3.
Epidemiology and potential mechanisms of tobacco smoking and heavy alcohol consumption in pancreatic cancer

Tobacco smoking represents an important known cause of ductal pancreatic adenocarcinoma. Recent data from pooled analyses in consortia involving multiple case–control and cohort studies suggest that heavy (but not moderate or light) alcohol consumption also may increase pancreatic cancer risk. Animal and human evidence indicate that tobacco carcinogens and metabolites may act in concert and have both genetic and epigenetic effects at early and later stages in pancreatic tumorigenesis. One of the more important tobacco‐related carcinogens, NNK, probably acts via multiple pathways. Heavy alcohol consumption may increase pancreatic cancer risk by potentiating the effects of other risk factors such as tobacco smoking, poor nutrition, and inflammatory pathways related to chronic pancreatitis, but also may have independent genetic and epigenetic effects. Animal and human studies of tobacco‐ and alcohol‐related pancreatic carcinogenesis suggest multi‐modal, overlapping mechanistic pathways. Tobacco smoking and heavy alcohol consumption are preventable exposures, and their avoidance would substantially decrease the burden of pancreatic cancer worldwide. © 2011 Wiley Periodicals, Inc.
Studies on Micropropagation of Pineapple ( Ananas comosus L . )

The present study was conducted at the Tissue Culture Laboratory, Horticulture, Research Institute, Agricultural Research Center (ARC), Egypt during the period from December 2013 to March 2016 to investigate the effect of different type Murashige and Skooge (MS), Gamborge (B5) and Woody plant media (WPM) at four salt concentrations (Full, 3⁄4, 1⁄2 and 1⁄4) of culture media on micropropagability of pineapple (Ananas comosus L. var. Smooth Cayenne) during establishment stage. Shootlet proliferations were investigated at different concentrations of 6-benzyle amino purine (BAP) and kinitine (Kin) at 0.25, 0.5, 1.0 and 2.0 mg/l for each, during two successive subcultures. Finally, rooting capacity were studied by various concentrations of indole butyric acid (IBA) and indole acetic acid (IAA) at1.0, 2.0 and 3.0 mg/l on media containing activated charcoal. The rooted explants were transferred to greenhouse in peat moss and sand at various amounts 1:1, 1:2 and 2:1, respectively. The culture crowns were successfully disinfecting by Colorex 40% for 20 min with 77.77% survival and 100% free contamination. MS media at full strength was the best culture media showed shootlet number 1.75 shootlet/explant and shootlet length 2.25 cm with 9.25 leaf/shootlets. Among the different concentrations 2.0 mg/l BAP showed highest shoot proliferation of 56 and 42 shoots per explant at the first and second subculture, respectively. The longest shoot (5.5 and 5.5 cm) was produced in the two subcultures by the treatment combination of 0.25 mg/l BAP. The highest numbers of roots were produced by 1.0mg/l IAA were 10.67 roots/shootlet and the tallest length of roots were obtained for explants cultured on MS media containing IAA 3 mg/l. The individual rooted explants derived from plantlets were transferred to poly bags in the green house at mixture media after 7 days hardening in room temperature (28-30°C) and established plantlet was ready
Facies analysis , sequence stratigraphy and chemostratigraphy of the Sete Lagoas Formation ( Bambui Group ) , northern Minas Gerais State , Brazil : evidence of a cap carbonate deposited on the Januária basement high

Manuscript ID: 20160112. Received in: 09/14/2016. Approved in: 01/19/2017. ABSTRACT: Sedimentary rocks of the Sete Lagoas Formation, exposed in the left margin of the São Francisco river (Minas Gerais State, Brazil), were deposited on the Januária‐Itacarambi basement high. They show both lateral and vertical rock stack‐ ing along continuous outcrops, allowing us to carry out detailed facies analysis and sequence stratigraphy studies. Our studies also integrate data from geological mapping, macro and micro‐ scopic petrography and high‐resolution C and O isotope analy‐ sis. Eight facies and four facies associations make up a sequence composed by a transgressive tract in the base, and a high stand tract in the upper portion, separated by a maximum flooding surface. The high stand tract shows a progradation stacking from the basement high apex towards progressively deeper base‐ ment areas. This stratigraphic framework, associated with oth‐ ers stratigraphic and isotopic features, indicates that the now exposed Januária basement high also represents a paleo‐high during the sedimentation event. Aragonite pseudomorphs and dolomites coupled with δ13C values of ‐5‰ characterize the basal carbonate of the transgressive tract as a cap carbonate. Records of the Cloudina fossil, recognized in the high stand tract, indicate a Late Ediacaran age for the upper portion of the studied stratigraphic sequence.
Biphasic Model Of Lung Deformations For Video-Assisted Thoracoscopic Surgery (VATS)

Intraoperative localization of small, low-density or deep lung nodules during Video-Assisted Thoracoscopic Surgery (VATS) is a challenging task. Localization techniques used in current practice require an additional preoperative procedure that adds complexity to the intervention and might yield to clinical complications. Therefore, clinical practice may benefit from alternative, intraoperative localization methods. We propose a nonrigid registration approach for nodule localization. Our method is based on a biomechanical model of the lung, where the lung parenchyma is represented as a biphasic medium. Preliminary results are promising, with target registration errors reduced from 28.39 mm to 9.86 mm in median, and to 3.68 mm for the nodule in particular.
Social-media habit of Rural India : Literature Review

There is a have and have not syndrome in India when it comes to social-media usage. A slight shift is seen when it comes to social media habit of rural chunk. Gradually the rural mass is getting addicted to the digi-trends and this is a positive shift. A lot of research has been done in silos in this context but this paper makes them all in a nutshell.