Miracle-dz/UniFAR-FTUs huggingface dataset:
Les études hédoniques soutiennent-elles une valeur verte élevée dans le bâtiment ? Une réponse par la méta-analyse

La place majeure occupee par le secteur du bâtiment dans la consommation d'energie (40%) et les emissions de gaz a effet de serre (1/3 des emissions) explique le developpement du debat scientifique axe sur la reduction de l'impact environnemental du bâtit et sur ses leviers. Ces dernieres annees ont notamment vu croitre une litterature considerable relative a la disposition a payer du public pour les bâtiments « verts » labelises par des ecolabels, cette « valeur verte » etant estimee dans la grande majorite des etudes via des modeles hedoniques. Dans cet article, nous proposons d'offrir une synthese de ces resultats dans le cadre d'une meta-analyse portant sur plus d'une cinquantaine d'etudes a travers le monde. Deux resultats sont produits. Grâce a un modele a effets aleatoires multi-niveaux et une regression MCO ponderee robuste au regroupement, nous fournissons tout d'abord une estimation moyenne ainsi qu'un intervalle de confiance du premium de prix concede par les agents economiques (prix de vente) pour acceder a un bâtiment vert. Cette estimation nous permet de corroborer l'interet et la pertinence economique de l'investissement dans la renovation du bâtiment. Toutefois, un important biais de publication semble affecter cette thematique et sa correction amene a une division par deux de la valeur verte immobiliere (de 8 a 4 %). Ensuite, nous analysons les facteurs susceptibles d'etre a la source de la dispersion des resultats via une meta-regression basee sur differents moderateurs (type de publication, periode d'analyse et zone geographique de l'echantillon, technique econometrique employee…). Divers tests statistiques et methodes alternatives de selection sont egalement realises pour etayer la robustesse de ces resultats. Nous terminons par un certain nombre de recommandations a destination des recherches futures permettant une meilleure comparabilite des resultats ainsi que par des suggestions aptes a eclairer l'efficacite des politiques publiques visant la soutenabilite du secteur du bâtiment.
Epstein-Barr Virus Infection and Altered Control of Apoptotic Pathways in Posttransplant Lymphoproliferative Disorders

Posttransplant lymphoproliferative disorders (PTLD) represent a spectrum of lymphoid diseases complicating the clinical course of transplant recipients. Most PTLD are Epstein-Barr virus (EBV) associated with viral latency type III. Several in vitro studies have revealed an interaction between EBV latency proteins and molecules of the apoptosis pathway. Data on human PTLD regarding an association between Bcl-2 family proteins and EBV are scarce. We analyzed 60 primary PTLD for expression of 8 anti- (Bcl-2, Bcl-XL, and Mcl-1) and proapoptotic proteins (Bak and Bax), the so-called BH3-only proteins (Bad, Bid, Bim, and Puma), as well as the apoptosis effector cleaved PARP by immunohistochemistry. Bim and cleaved PARP were both significantly (p = 0.001 and p = 5.251e-6) downregulated in EBV-positive compared to EBV-negative PTLD [Bim: 6/40 (15%), cleaved PARP: 10/43 (23%), vs. Bim: 13/16 (81%), cleaved PARP: 12/17 (71%)]. Additionally, we observed a tendency toward increased Bcl-2 protein expression (p = 0.24) in EBV-positive PTLD. Hence, we provide evidence of a distinct regulation of Bcl-2 family proteins in EBV-positive versus negative PTLD. The low-expression pattern of the proapoptotic proteins Bim and cleaved PARP together with the high-expression pattern of the antiapoptotic protein Bcl-2 by trend in EBV-positive tumor cells suggests disruption of the apoptotic pathway by EBV in PTLD, promoting survival signals in the host cells.
A novel method for monitoring Mycobacterium bovis BCG trafficking with recombinant BCG expressing green fluorescent protein

To better understand intracellular and extracellular trafficking of Mycobacterium bovis bacillus Calmette-Guérin (BCG) when used as an intravesical agent in the treatment of transitional cell carcinoma (TCC) of the bladder, recombinant BCG (rBCG) expressing the jellyfish green fluorescent protein (GFP) was created. When the MB49.1 murine TCC cell line was incubated with GFP-expressing rBCG, internalization of the pathogen could be directly visualized by UV microscopy and quantitated by flow cytometry. The in vitro internalization of the GFP rBCG by the bladder tumor cells was temperature dependent, occurring most readily at 37 degrees C and being severely inhibited at 4 degrees C. Optimum internalization was achieved in vitro at a 10:1 BCG-to-tumor cell ratio over 24 h during which approximately 16% of the tumor cells became infected. Cytochalasin B, a phagocytosis inhibitor, abrogated the ingestion by almost 100% at a concentration of 200 micrograms/ml, indicating that contractile microfilaments likely played an important role in this process. By using mitomycin, a DNA cross-linking reagent, to inhibit proliferation of MB49.1 cells, clearance of about 40% of the green rBCG was achieved by 3 days postinfection. No significant difference between the GFP rBCG and wild-type BCG was observed in the ability to induce the expression of cell membrane proteins of major histocompatibility classes I and II, ICAM-I and -II, B7-1 and -2, of Fas from MB49.1 cells or cytokine production from mouse spleen cells. These results indicate that GFP rBCG may serve as a useful substitute for wild-type BCG in future studies of in vivo trafficking experimental and clinical immunotherapy.
Effect of Ethanol Administration on Striatal D1 and D2 Dopamine Receptors

Abstract: Chronic in vivo exposure of rats to ethanol in a complete liquid diet for 14 or 21 days produced a behavioral tolerance to the acute injection of ethanol. After 21 days, but not 14 days, of chronic exposure, there was a significant increase in the maximum density of striatal D1 and D2 dopamine receptors without a change in these receptors' affinities. A 24‐h withdrawal from the 21‐day exposure did not alter the observed increase in density. Both the level and duration of ethanol exposure appear to be important variables for demonstration of an increase in striatal D1 and D2 dopamine receptors.
Store-Operated CRAC Channels Regulate Gene Expression and Proliferation in Neural Progenitor Cells

Calcium signals regulate many critical processes during vertebrate brain development including neurogenesis, neurotransmitter specification, and axonal outgrowth. However, the identity of the ion channels mediating Ca2+ signaling in the developing nervous system is not well defined. Here, we report that embryonic and adult mouse neural stem/progenitor cells (NSCs/NPCs) exhibit store-operated Ca2+ entry (SOCE) mediated by Ca2+ release-activated Ca2+ (CRAC) channels. SOCE in NPCs was blocked by the CRAC channel inhibitors La3+, BTP2, and 2-APB and Western blots revealed the presence of the canonical CRAC channel proteins STIM1 and Orai1. Knock down of STIM1 or Orai1 significantly diminished SOCE in NPCs, and SOCE was lost in NPCs from transgenic mice lacking Orai1 or STIM1 and in knock-in mice expressing the loss-of-function Orai1 mutant, R93W. Therefore, STIM1 and Orai1 make essential contributions to SOCE in NPCs. SOCE in NPCs was activated by epidermal growth factor and acetylcholine, the latter occurring through muscarinic receptors. Activation of SOCE stimulated gene transcription through calcineurin/NFAT (nuclear factor of activated T cells) signaling through a mechanism consistent with local Ca2+ signaling by Ca2+ microdomains near CRAC channels. Importantly, suppression or deletion of STIM1 and Orai1 expression significantly attenuated proliferation of embryonic and adult NPCs cultured as neurospheres and, in vivo, in the subventricular zone of adult mice. These findings show that CRAC channels serve as a major route of Ca2+ entry in NPCs and regulate key effector functions including gene expression and proliferation, indicating that CRAC channels are important regulators of mammalian neurogenesis.
Human-robot interaction design using Interaction Composer eight years of lessons learned

Interaction Composer, a visual programming environment designed to enable programmers and non-programmers to collaboratively design social human-robot interactions in the form of state-based flows, has been in use at our laboratory for eight years. The system architecture and the design principles behind the framework have been presented in other work, but in this paper we take a case-study approach, examining several actual examples of the use of this toolkit over an eight-year period. We examine the structure and content of interaction flows, identify common design patterns, and discuss elements of the framework which have proven valuable, features which did not solve their intended purposes, and ways that future systems might better address these issues. It is hoped that the insights gained from this study will contribute to the development of more effective and more usable tools and frameworks for interaction design.
Recurrent and Prolonged Infections in a Child with a Homozygous IFIH1 Nonsense Mutation

In an Egyptian girl born to consanguineous parents, whole-exome sequencing (WES) identified a homozygous mutation in PHGDH, c.1273G>A (p.Val425Met), indicating 3-phosphoglycerate dehydrogenase deficiency. This diagnosis was compatible with the patient’s microcephaly, severe psychomotor retardation, seizures and cataracts. However, she additionally suffered from recurrent (at least monthly) episodes of prolonged and severe chest infections requiring hospitalization, suggesting a secondary, predisposing and potentially Mendelian, condition. A local reactivation of an EBV infection in the respiratory tract was detected after a recent chest infection, likely representing an opportunistic infection based on a compromised immune system. Further inspection of WES data revealed a homozygous nonsense mutation, c.2665A>T (p.Lys889∗), in IFIH1, encoding MDA5. MDA5 detects long viral double-stranded RNA that is generated during replication of picorna viruses, and thereby activates the type I interferon signaling pathway. The results of Western blot analysis of protein from cultured fibroblasts of the patient indicates absence of wild type MDA5/IFIH1, compatible with NMD. We propose that, analogous to the severe course of primary influenza infection due to biallelic deficiency of a downstream effector, IRF7, homozygous loss of IFIH1 defines a novel Mendelian immunodeficiency disorder that increases susceptibility to severe viral infections. This is contrasted to heterozygous gain-of-function IFIH1 mutations in autoimmune diseases. Our findings highlight the potential of comprehensive genomic investigations in patients from consanguineous families to identify monogenic predispositions to severe infections.
In the weeds: distinguishing organic farmers who want information about ecological weed management from those who need it

Abstract The benefits of farming organically in the USA are increasingly known; however, organic farmers also encounter considerable risks, especially from weeds. Without herbicides, organic farmers can rely only on crop rotations, mechanical cultivation, manual weeding, beneficial insects and other cultural practices, termed ecological weed management (EWM), to control weeds. Despite promising results and the many ways in which EWM can be employed, it remains poorly adopted by the organic community. Organic farmers resist research and recommendations from University scientists and Extension, instead preferring to rely on local family and friends and their own experience to guide decisions. Here we investigate factors that may lead organic farmers to recognize that they need additional information about EWM and to seek that information out. Using a national survey of organic farmers (n = 554) and a risk-information seeking and processing model, we show that farmers’ risk and benefit perceptions, worry, social norms encouraging seeking out information, and farmers’ own perceived knowledge gaps, particularly with respect to their most problematic weed, influence information-seeking behavior. Identifying characteristics that may distinguish those organic farmers who need and want additional information, we provide recommendations to Extension and University scientists about how best to communicate, build trust and provide decision support to the organic community with respect to EWM.
Bedside screening tests vs. videofluoroscopy or fibreoptic endoscopic evaluation of swallowing to detect dysphagia in patients with neurological disorders: systematic review.

AIM This paper is a report of a systematic review conducted to determine the effectiveness and feasibility of bedside screening methods for detecting dysphagia in patients with neurological disorders. BACKGROUND Dyspaghia affects 22-65% of patients with neurological conditions. Although there is a large variety of bedside tests to detect dysphagia, it is unknown which have the best psychometric properties and are feasible for nurses to use. DATA SOURCES AND REVIEW METHODS An electronic database search was carried out using Medline (PubMed), Embase, CINAHL, and PsychLit, including all hits up to July 2008. The search terms were dysphagia, sensitivity, specificity, diagnosis, and screening. The methodological quality of included studies was assessed. RESULTS Thirty-five out of 407 studies were included in the review. Eleven studies with sufficient methodological quality revealed that trial swallow tests using water had sensitivities between 27% and 85% and specificities between 63% and 88%. Trial swallow tests with different viscosities led to sensitivities ranging from 41% to 100% and specificities of 57% to 82%. Combining water tests with oxygen desaturation led to sensitivities between 73% and 98% and specificities between 63% and 76%. Single clinical features, such as abnormal gag, generally had low sensitivity and specificity. CONCLUSION A water test combined with pulse oximetry using coughing, choking and voice alteration as endpoints is currently the best method to screen patients with neurological disorders for dysphagia. Further research is needed to establish the most effective standardized administration procedure for such a water test, and to assess the value of pulse oximetry, in addition to a trial swallow to detect silent aspiration.
Risk factors for persistent chronic widespread pain: a community-based study.

BACKGROUND Chronic widespread pain is the cardinal clinical feature of the fibromyalgia syndrome, which, in the majority of clinic patients, is persistent. By contrast, in community-derived patients, pain is persistent in only half of the affected individuals, particularly those with psychological distress. Whether such distress is a consequence of the pain or a manifestation of a wider process of somatization which is associated with the persistence of pain is unclear. OBJECTIVES We tested in a large, prospective, population-based study the hypothesis that features of somatization predict the persistence of chronic widespread pain. METHODS In all, 252 (13%) of 1953 adult subjects selected from a population register were classified as having chronic widespread pain based on a detailed questionnaire which included a pain drawing. The patients also completed a number of psychosocial instruments which measure features known to be associated with somatization. Two hundred and twenty-five (91%) of the patients were successfully followed up after 12 months and provided data on pain status using the same instruments. RESULTS In all, 126 (56%) patients reported chronic widespread pain at follow-up, 74 (33%) reported other pain and 25 (11%) reported no pain. Persistent chronic widespread pain was strongly associated with baseline test scores for high psychological distress and fatigue. In addition, these subjects were more likely to display a pattern of illness behaviour characterized by frequent visits to medical practitioners for symptoms which disrupt daily activities. The prevalence of persistent pain increased with the number of risk factors the subjects were exposed to. CONCLUSIONS Although almost half of the cases of chronic widespread pain resolved within 1 yr, this study has demonstrated for the first time that those subjects who display features of somatization are more likely to have widespread pain which persists. These findings have implications for the identification and treatment of persons with persistent chronic widespread pain.
Collaborative-based HRM practices and open innovation: a conceptual review

Abstract This conceptual paper analyses the role of collaborative-based HRM practices in supporting open innovation. There is already an extensive literature that investigates the impact of HRM practices on organizations’ innovation performance. As organizational boundaries become increasingly permeable and knowledge flows more freely, open innovation continues to receive close attention in management studies. However, relationships between HRM practices and open innovation have still not been examined. From a knowledge management perspective, we identify three kinds of barrier that may deter or impede open innovation. These relate to cognitive biases, concerns about transaction costs, and shortfalls in terms of organization capability. We also discuss the role of four types of collaboration-oriented HRM practices (i.e., teamwork-based recruitment, training in teamwork skills, team-based appraisals and rewards, and rotational job design) in reducing barriers to open innovation. Based on our analyses, we envisage future research directions about the role of collaborative-based HRM practices in supporting open innovation.
Heterosexuals' attitudes toward bisexual men and women in the United States

This paper examines heterosexual adults’ attitudes toward bisexual men and women using data from a 1999 national RDD survey (N = 1,335). Ratings on 101‐point feeling thermometers were lower (less favorable) for bisexual men and bisexual women than for all other groups assessed—including religious, racial, ethnic, and political groups—except injecting drug users. More negative attitudes toward bisexuals were associated with higher age, less education, lower annual income, residence in the South and rural areas, higher religiosity, political conservatism, traditional values concerning gender and sexual behavior, authoritarianism, and lack of contact with gay men or lesbians. White heterosexual women expressed significantly more favorable attitudes than other women and all men. A gender difference was observed in attitudes toward bisexuals and homosexuals: Heterosexual women rated bisexuals significantly less favorably than they rated homosexuals, regardless of gender, whereas heterosexual men rated male targets less favorably than female targets, regardless of whether the target was bisexual or homosexual.
Issues in NiSi-gated FDSOI device integration

Thin-body fully depleted silicon on insulator (FDSOI) devices with NiSi metal gates were fabricated with gate lengths down to 20 nm. Specific issues in the integration of the NiSi-gated FDSOI devices were investigated, in particular: gate CMP, the phase stability of the nickel silicide, and parasitic resistance.
Expression of retinoid‐related orphan receptor (ROR)γt on NK22 cells in the peripheral blood and uterine endometrium of women with unexplained recurrent pregnancy loss and unexplained infertility

Recently, NK22 cells, a subset of interleukin (IL)‐22‐producing natural killer (NK) cells, were identified. We have previously reported the higher percentage of NK22 cells in women suffering recurrent pregnancy loss (RPL). Moreover, we have also reported lower expression of NKp46, a kind of natural cytotoxicity receptor (NCR), on NK cells and the changes of NK cell producing cytokines in women who experience RPL. NK22 cells express NCRs, such as NKp44 or NKp46. Retinoid‐related orphan receptor γt (RORγt) is known as a regulator of NK22 cells; however, in NK22 cells of peripheral blood (PB) and the uterine endometrium (UE), the relationship between NCRs and RORγt is unclear. We investigate RORγt expression NK22 cells in the PB and UE of women with unexplained infertility (uI) or unexplained RPL (uRPL).
Examining Forward and Backward Linkages between Public and Private Investments

Proper working of forward and backward linkages between the public and private investments in the face of balanced development of an economy is an already established fact in the literature of development economics.The present article is aimed at examining the working of these two linkage effects upon the economies of 24 countries in different economic status: whether public capital is more productive than private capital and finally to test whether public investments crowd-in or crowd-out the private investments for the period 1988–2013. The results show that, for the entire period, forward linkage has worked for Spain, Senegal and Ecuador and backward linkages worked for United States of America, United Kingdom, Thailand, South Africa, Nigeria, Cambodia, Rwanda and Paraguay. Both forward and backward linkages have happened for Ireland, China, India, Brazil and Peru. For the second objective, the numbers of instances of the income-generative capacities of both types of investments are a few in the entire as well pre-crisis phases unlike that of the post-crisis phase. And the results of the third objective show that there are the maximum instances in favour of crowding-in effects from either private to public or from public to private in all the time phases and a few instances in crowding-out effects. JEL: O18, H54, E22, E01
Mg2+‐Dependent Modulation of BKCa Channels by Genistein in Rat Arteriolar Smooth Muscle Cells

Genistein, a protein tyrosine kinase (PTK) inhibitor, regulates ion channel activities. However, the mechanism of action of genistein on large‐conductance calcium‐activated potassium (BKCa) channels is unclear. This study aimed to investigate whether the mechanism of Mg2+‐dependent modulation of BKCa channel activity in vascular smooth muscle cells involved inhibition of phosphorylation by genistein or direct interaction between genistein and BKCa channels. The whole‐cell and inside‐out patch‐clamp techniques were used to measure BKCa currents and the effects of genistein on BKCa channel activities in rat mesenteric arteriolar smooth muscle cells. We found that the effects of genistein on BKCa currents were Mg2+‐dependent. Genistein (50 μM) inhibited BKCa currents if the intracellular free magnesium concentration ([Mg2+]i) was 2 μM or 20 μM, but amplified BKCa currents if [Mg2+]i was 200 μM or 2000 μM. The inhibitory effect of genistein on BKCa currents was reversed by the protein tyrosine phosphatase inhibitor sodium orthovanadate (0.5 mM). Daidzein (50 μM), an inactive analogue of genistein, also amplified BKCa currents, and its amplification was insensitive to orthovanadate. Another PTK inhibitor, tyrphostin 23 (50 μM), reduced the open probability of BKCa channels. This inhibitory effect was weaker at 200 μM [Mg2+]i than at 2 μM [Mg2+]i, and was countered by orthovanadate. Our results suggest that genistein amplifies BKCa currents at a high [Mg2+]i, but inhibits BKCa currents at a low [Mg2+]i. The mechanism of this biphasic effects involves PTK‐independent amplification and [Mg2+]i‐PTK‐dependent inhibition. J. Cell. Physiol. 229: 1981–1989, 2014. © 2014 Wiley Periodicals, Inc.
Planning for connections in the long-term in Patagonia.

The relict flora of Gondwanda, the mystic nature of the windswept Patagonian steppe, the Andes mountains and the southern beech forests, all combined, made San Carlos de Bariloche the perfect setting for gathering researchers from North and South Americato discussa common goal:establishing a program of research and scientific interaction focused on long-term ecologicalquestions in northern Patagonia.The 4-<l. workshop was funded by the National Science Foundation of the USA, and by the local scientific agencies of the Consejo Nacional de Investigaciones Cientfficas y Tecnicas (CONICET) and the Agencia Nacional de Promoci6n Cientifica y Tecnolgica (ANPCyT), and was led by Barbara Bond (Oregon State University, USA), Claudio Ghersa