Miracle-dz/UniFAR-FTUs huggingface dataset:
Strategies of pro-European parties in the face of a Eurosceptic challenge

We ask how pro-European parties communicate in the face of a Eurosceptic challenge and how this affects the politicization of European Union integration within a country. We draw on a quantitative content analysis of parties’ press releases issued in the run-up to the 2014 European Parliament elections in seven countries. Our results show that pro-European parties as such put Europe on the agenda, debate issues similar to those voiced by Eurosceptics and defend their pro-European positions: yet, they do so to varying degrees and with major exceptions. It is pro-European catch-all parties with strong internal dissent that silence Europe and choose blurring or adoption strategies. Consequently, the politicization of European integration varies among countries, thereby high topic visibility is accompanied by low levels of party conflict.
Lumbosacral plexus neuritis

We studied four patients with neurologic disorders of the lumbosacral plexus. Except for location of symptoms, the disorder conformed to criteria established for the clinical diagnosis of brachial plexus neuritis. Acute onset of pain in one or both legs was followed by weakness, loss of stretch reflexes, and sometimes atrophy of affected muscles. The disorder affected individual nerves or parts of the plexus. Gradual recovery occurred in all four patients.
Relation between blood pressure and outcome in intracerebral hemorrhage.

BACKGROUND AND PURPOSE Controversy continues to exist regarding optimal blood pressure control in acute hypertensive intracerebral hemorrhage. Persistent marked elevation of the blood pressure can promote further bleeding, increase cerebral blood flow, and raise intracranial pressure. Relative hypotension, on the other hand, may promote hypoperfusion with secondary ischemia. This study was designed to assess outcome in patient groups defined by the degree of elevation in their pretreatment and posttreatment blood pressures. METHODS We retrospectively assessed 87 patients who were categorized according to an initial mean arterial pressure > 145 mm Hg (n = 34) compared with those with a pressure < or = 145 mm Hg (n = 53). We also studied blood pressure control within the first 2 to 6 hours of presentation with subjects categorized according to a mean arterial pressure > 125 mm Hg (n = 40) or < or = 125 mm Hg (n = 47). RESULTS An improved outcome in both mortality and severe morbidity was observed in the < or = 145 (chi 2 = 7.0, P < .005) and the < or = 125 mm Hg (chi 2 = 6.7, P < .005) groups. CONCLUSIONS Markedly elevated blood pressure on admission and persistent inadequate blood pressure control adversely affect the prognosis in hypertensive intracerebral hemorrhage.
Worldwide Haemophilus influenzae type b disease at the beginning of the 21st century: global analysis of the disease burden 25 years after the use of the polysaccharide vaccine and a decade after the advent of conjugates.

Vaccination against Haemophilus influenzae type b (Hib) diseases began a quarter of a century ago with a polysaccharide vaccine; this vaccine was followed by four different conjugates 10 years later. In this review, the burden of global Hib disease is quantified following this 25-year period of vaccine availability to determine the potential impact of conjugate vaccines. This task was accomplished by analysis of data available in 10 languages in 75 geographical regions of over 50 countries. All severe Hib diseases, not only meningitis, were characterized, and special attention was paid to the most vulnerable age group, i.e., children aged 0 to 4 years. Prior to vaccination, the weighted worldwide incidence of meningitis in patients younger than 5 years was 57/100,000, and for all Hib diseases except nonbacteremic pneumonia, it was 71/100,000, indicating 357,000 and 445,000 cases per year, respectively. At least 108,500 of these children died. For all age groups combined, there were 486,000 cases of Hib disease, excluding pneumonia, with 114,200 deaths and probably an equal number of sequelae per annum. If the figures for nonbacteremic pneumonia are included, a conservative estimate is that over 2.2 million cases of infection and 520,000 deaths from Hib disease occurred worldwide, but the true numbers might have been greater. Despite these large numbers and availability of safe and efficacious vaccines, only 38,000 cases annually are prevented-a meager 8% or less than a 2% reduction in cases, depending on whether nonbacteremic pneumonia is included in the calculations. Although vaccination has had great success in some affluent countries, the current level of activity has had a very small impact globally. The use of conjugates, preferably with a reduced number of doses and in combination with other vaccines or perhaps in fractional doses, should be extended to less privileged countries, where most Hib disease occurs.
Police public relations in the age of social media

This research examines the concept of public relations in the English police; what it is, how it has changed and the problems police forces now face with regard to communications. The last two decades has seen a transformation within police public relations as it has become increasingly standardised, corporatized, professionalised and more open, playing a key part in the police transparency agenda. Police officers have been replaced by civilian experts as the departments have grown in size which has led to changes in the structure, strategy and ideology as these departments have adapted to the new challenges posed by social media, severely restricted budgets, apparent loss of public confidence and public cynicism. Since 2009 England’s police forces have become increasingly active online. There is very little research, however, into how and why social media is being used by the police, how it fits into the broader communication strategies, and how this is changing traditional police public relations. During this study a national comparison of police forces was undertaken to investigate these issues. What emerged was a picture of dynamic tension between change and continuity within police communications around identity, ideology, form and function. Once an understaffed, ancillary function, affiliated to but not part of ‘real police work’, most police public relations departments are now considered an “operationally essential” part of modern policing in their force. Social media has enabled police forces to communicate directly to and with large segments of the populous for the first time. This research has also identified strong evidence of the emergence of a new model, that of ‘direct and digital’ within police communications. This new approach appears to be moving police communications from primarily a reactive service to a proactive dialogical one that is increasingly looking to engage with audiences directly online rather than through conventional methods.
Motion correction and registration of high b‐value diffusion weighted images

It has been suggested that, high b‐value diffusion weighted MRI improves the sensitivity and specificity of these images to tissue microstructure when compared with “clinical” b‐value diffusion weighted MRI (b ≈ 1000 s/mm2). However, it suffers from poor signal to noise ratio ‐ leading to longer acquisition times and therefore more motion artifacts. Together with the orientational sensitivity of the diffusion weighted MRI signal, the contrast at different b‐values and different gradient directions is significantly different. These features of high b‐value diffusion images preclude the ability to perform conventional image‐registration‐based motion/distortion correction. Here, we suggest a framework based on both experimental data (diffusion tensor MRI) and simulations (using the composite hindered and restricted model of diffusion framework) to correct the motion induced misalignments and artifacts of high b‐value diffusion weighted MRI. This approach was evaluated using visual assessment of the registered diffusion weighted MRI and the composite hindered and restricted model of diffusion analysis results, as well as residual analysis to assess the quality of the composite hindered and restricted model of diffusion fitting. Both qualitative and quantitative results demonstrate an improvement in fitting the data to the composite hindered and restricted model of diffusion model following the suggested registration framework, thereby, addressing a long‐standing problem and making the correction of motion/distortions in data collected at high b‐values feasible for the first time. Magn Reson Med, 2011. © 2011 Wiley Periodicals, Inc.
Pour une approche diagnostique de l’autisme en République Démocratique du Congo

La presente recherche porte sur l’approche du diagnostic de l’autisme realise en milieu africain ou, dans la majorite des communautes, les personnes autistes non seulement ne recoivent pas ce diagnostic, mais certains sont par ailleurs assimiles au diagnostic social de la sorcellerie. L’etude consiste a evaluer une population de personnes qui presentent une deficience intellectuelle, une surdite, une maladie mentale ou un diagnostic social de la sorcellerie. L’objectif consiste a d’identifier, parmi elles, celles qui repondent non seulement aux criteres de diagnostic des Troubles Envahissants de Developpement (TED), mais aussi celles qui sont autistes. L’echelle d’evaluation des troubles Envahissants de developpement et des autres troubles apparentes (EATA) a servi au depistage des participants presentant un TED. Le CARS et l’ADI-R ont permis d’identifier, parmi les participants presentant un TED, ceux qui sont autistes. Tous les participants autistes presentent egalement un diagnostic de deficience intellectuelle mesure a l’aide du test de Bonhomme de Goodenough et de la Wechsler Intelligence Scale for Children (WISC-R). Les resultats confirment que l'autisme peut etre identifie dans la population des enfants qui presentent des troubles de developpement divers. Dans le contexte africain, les enfants autistes peuvent donc etre identifies parmi ceux qui sont consideres comme presentant de la sorcellerie.
A Double‐Blind Study of Tranylcypromine Treatment of Major Anergic Depression

Fifty-nine anergically depressed patients were randomly assigned to 6 weeks of double-blind treatment with either tranylcypromine or placebo. Anergic major depression most typically occurs in primary bipolar and in pseudounipolar affective illnesses. We hypothesized that tranylcypromine would be a highly effective and rapid treatment for depressions of this type. Results of repeated measures analyses of variance showed superiority of active drug over placebo by the end of the first week, and this improvement increased in significance at each successive visit. Improvement on tranylcypromine after week 1 was greater than that on placebo after week 6. Analysis of covariance of week 6 scores (corrected for week 0 scores) showed significantly greater improvement for tranylcypromine patients on all measures of depressive symptomatology. Tranylcypromine is a rapid, relatively safe, and dramatically effective treatment for anergic depression. Since 24 of 29 of the bipolar subjects had previously failed to respond to tricyclics and since bipolar depression is usually anergic, tranylcypromine should be compared to imipramine to determine the antidepressant of choice for manic-depressive illness.
Borna disease virus (BDV), a nonsegmented RNA virus, replicates in the nuclei of infected cells where infectious BDV ribonucleoproteins are present

Borna disease virus (BDV) causes neurological disease in a wide range of animal species, providing an important model for studies of persistent viral infection of the central nervous system. In addition, the detection of antibodies that react with BDV antigen in serum from psychiatric patients suggests a role for BDV, or related viruses, in human mental disorders, providing further reason for study of this poorly characterized neurotropic virus. We present evidence that BDV has a nonsegmented negative single-strand RNA genome with the property that viral replication and transcription take place in the nuclei of infected cells where infectious BDV ribonucleoproteins are present. Our results support the view that BDV has unique biological features among animal viruses. Furthermore, the finding that BDV ribonucleoproteins are able to infect susceptible cells raises interesting questions regarding the mechanisms by which some neurotropic viruses may spread through the central nervous system of the infected host without requiring the production of mature infectious virus.
In vitro action of carboxyfullerene.

Fullerene compounds have avid reactivity with free radicals and are regarded as 'radical sponges'. The trimalonic acid derivative of fullerene is one of the water-soluble compounds that has been synthesized and found to be an effective antioxidant both in vivo and in vitro. Carboxyfullerene has been shown to be effective in the treatment of both Gram-positive and -negative infections, although its mode of action is poorly understood. We determined the MIC and minimal bactericidal concentration of carboxyfullerene for 20 isolates, including Staphylococcus spp. , Streptococcus spp. , Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi and Klebsiella pneumoniae. We further investigated the action of carboxyfullerene using transmission electron microscopy (TEM), anticarboxyfullerene antibody binding assay and a membrane perturbation assay. All Gram-positive species were inhibited by < or = 50 mg/L of carboxyfullerene, whereas Gram-negative species were not inhibited, even at 500 mg/L carboxyfullerene. Bactericidal activity was demonstrated only for Gram-positive species, particularly for Streptococcus pyogenes A-20, which was killed rapidly. Intercalation of carboxyfullerene into the cell wall of staphylococci and streptococci was demonstrated by TEM and anti-carboxyfullerene binding assay. Damage to the cell membrane in Gram-positive, but not Gram-negative, bacteria was confirmed by the membrane perturbation assay. These findings indicate that the action of carboxyfullerene on Gram-positive bacteria is achieved by insertion into the cell wall and destruction of membrane integrity.
Follow-up of carriers of BRCA1 and BRCA2 variants of unknown significance: Variant reclassification and surgical decisions

Purpose: Approximately 5–10% of patients who undergo genetic testing of BRCA1 and BRCA2 receive a variant of unknown significance (VUS) result. The ambiguous nature of a VUS may increase difficulty in patient understanding and decision making regarding risk reduction and surveillance options, including cancer risk-reducing surgeries. VUS reclassification to benign or deleterious may occur in time; however, clinical decisions may need to be made expeditiously, and some patients may pursue irreversible treatments before VUS reclassification.Methods: We reviewed the surgical decisions of 107 women postdisclosure of a BRCA VUS result counseled at our institute between 1998 and 2009.Conclusion: Among women receiving a BRCA VUS result at our center, 11 of 107 (10.3%) pursued cancer risk-reducing mastectomy and 22 of 107 (20.6%) pursued cancer risk-reducing bilateral salpingo-oophorectomy. Reclassification of VUS occurred up to 9 years after testing, and 5 of 22 (22.7%) women followed up for 8 or more years continue to have a VUS result. We discuss considerations for providers of genetic services to discuss with patients who receive a VUS result.
Role of Phosphodiesterase III in the Antilipolytic Effect of Insulin in Vivo

The effect of three types of phosphodiesterase (PDE) inhibitors on in vivo antilipolysis was investigated in healthy subjects using a 2-h euglycemic, hyperinsulinemic (40 mU · m-2·min) clamp together with microdialysis of abdominal subcutaneous adipose tissue. During hyperinsulinemia (∼330 pmol/l), the circulating glycerol concentration was reduced to ∼50% of the basal level of 53.2 ± 3.6 μmol/l, indicating an antilipolytic effect. The decrease in adipose tissue dialysate glycerol, which mirrors the change in interstitial glycerol concentration, was about 40% during hyperinsulinemia when Ringer's solution alone was perfused. Local perfusion with a selective PDE IV inhibitor, rolipram (10−4) mol/l), did not influence the insulin-induced decrease in dialysate glycerol (F = 0.8 vs. perfusion with Ringer's solution by two-factor analysis of variance [ANOVA]), although rolipram increased the dialysate glycerol level by 144 ± 7% of the baseline value. However, local perfusion with a selective PDE III inhibitor, amrinone (10−3) mol/l), or a nonselective PDE inhibitor, theophylline (10−2) mol/l), abolished the ability of insulin to lower dialysate glycerol (F = 16.5, P < 0.01 and F = 8.5, P < 0.01, respectively, as compared with perfusion with Ringer's solution). The findings could not be explained by changes in the local blood flow (as measured by a microdialysis–ethanol escape technique), which was not affected by hyperinsulinemia in the presence or the absence of PDE inhibitors in the dialysis solvent. We conclude that PDEs play an important role in mediating the antilipolytic effect of insulin in vivo and that PDE III is the dominant isoenzyme modulating this effect.
Quantitative analysis of serum IL-6 and its correlation with increased levels of serum IL-2R in HIV-induced diseases.

We have devised a luminescence sandwich ELISA for the quantification of IL-6 in both sera and cell culture supernatants, which had a detection limit of 100 fg/ml of test sample. By using the luminescence sandwich-ELISA, low but measurable levels of IL-6 (9.5 pg/ml on average) were found in the sera from normal individuals. The serum levels of IL-6 were elevated in HIV-seropositive asymptomatic carriers (55.5 pg/ml on average), and the IL-6 levels were correlated with the degree of HIV-induced disease progression (AIDS-related complex 106.8 pg/ml on average and (AIDS 283 pg/ml). IL-6 immunoreactivity in the sera of AIDS patients eluted at a 25,000 m.w. major peak, which was biologically active and heat-stable, and a 500,000 m.w. minor peak in size-exclusion HPLC. Interestingly, a significant correlation was observed between the serum IL-6 levels and soluble IL-2R levels. In vitro, HIV infection of PHA-activated PBMC led to enhanced release of IL-6 into the culture supernatants. Moreover, soluble IL-2R release was markedly increased by adding exogenous IL-6, whereas it was decreased by adding the neutralizing anti-IL-6 mAb to the cultures. These results demonstrate that increased IL-6 levels are significantly associated with sIL-2R levels, and suggest a cause of the increased levels of this receptor in patients with HIV infection. Furthermore, both serum IL-6 and serum IL-2R levels in HIV infection reflect the stage of the HIV-induced disease.
A Novel, Selective, and Orally Available Antagonist for CC Chemokine Receptor 3

CC chemokine ligand 11 (CCL11/eotaxin) and other CC chemokine receptor 3 (CCR3) ligands (CCL24/eotaxin-2, CCL26/eotaxin-3, CCL13/monocyte chemotactic protein-4, etc.) play important roles in the chemotaxis and activation of eosinophils and other CCR3-expressing cells (basophils, mast cells, and CD4+ T helper 2 cells) in allergic inflammation incidents, including asthma and rhinitis. A newly synthesized compound, N-{(3R)-1-[(6-fluoro-2-naphthyl)methyl]pyrrolidin-3-yl}-2-{1-[(5-hydroxy-3-methylpyridin-2-yl)carbonyl]piperidin-4-ylidene}-acetamide hemifumarate (YM-355179), inhibited the binding of CCL11 and CCL5/regulated on activation normal T cell expressed and secreted to CCR3-expressing B300-19 cells with IC50 values of 7.6 and 24 nM, respectively. In contrast, YM-355179 did not affect the binding of CCL5 to CCR1 or CCR5. In functional assays, YM-355179 inhibited CCL11-induced, intracellular Ca2+ influx, chemotaxis, and eosinophil degranulation with IC50 values of 8.0, 24, and 29 nM, respectively. YM-355179 did not, however, affect any CC chemokine receptor (CCR1, CCR2, CCR4, or CCR5)-mediated Ca2+ influx signals. Furthermore, oral administration of YM-355179 (1 mg/kg) inhibited CCL11-induced shape change of whole blood eosinophils in cynomolgus monkeys. Intravenous injection of YM-355179 (1 mg/kg) also inhibited eosinophil infiltration into airways of cynomolgus monkeys after segmental bronchoprovocation with CCL11. These results indicate that YM-355179 is a novel, selective, and orally available CCR3 antagonist with therapeutic potential for treating eosinophil-related allergic inflammatory diseases.
The Value of True Liquidity

This study uncovers the ability of liquid stocks to generate significant higher risk-adjusted portfolio returns than their illiquid counterparts. Using U.S. stocks in the period of 01/1990 to 09/2015, we show that a significant negative illiquidity premium can be obtained when accounting for a high negative correlation between a stocks’ illiquidity and its market value of equity. The risk-adjusted orthogonalized illiquidity premium amounts to -0.576% per month and is robust to changes in the portfolio formation setting.
Matheuristic with machine-learning-based prediction for software-defined mobile metro-core networks

In general, humans follow a routine with highly predictable daily movements. For instance, we commute from home to work on a daily basis and visit a selected set of places for commercial and recreational purposes during the nights and weekends. The use of mobile phones increases when commuting via public transportation, during lunch breaks, and at night. Such regular behavior creates predictable spatiotemporal fluctuations of traffic patterns. In this paper, we introduce a matheuristic for dynamic optical routing, which can be implemented as an application into a software-defined mobile carrier network. We use machine learning to predict tidal traffic variations in a mobile metro-core network, which allows us to solve off-line mixed-integer linear programming instances of an optical routing (and wavelength) assignment optimization problem. The optimal results are used to favor near-optimal on-line routing decisions. Results demonstrate the effectiveness of our on-line methodology, with results that match almost perfectly the behavior of a network that performs optical routing reconfiguration with a perfect, oracle-like traffic prediction and the solution of an optimization problem.