Miracle-dz/UniFAR-FTUs huggingface dataset:
Psychomotor Performance of Medical Students: Effect of 24 Hours of Sleep Deprivation

Context: Sleep deprivation is known to have detrimental effects on attentional resources and cognitive functions. Aim: The aim of this study is to assess the changes in performance, due to 24 h of sleep deprivation, in medical students Materials and Methods: The performance was assessed using simple paper–pencil tasks, such as digit symbol substitution test, digit vigilance test, and letter cancellation tasks. Results: The results revealed an increase in the number of errors in letter cancellation tasks and digit vigilance test, with a significant decrease in the number of correct responses on the letter cancellation task. The time taken to complete the tests increased with lack of sleep, with the digit symbol substitution test being affected the most. Discussion: This study infers that sleep deprivation for 24 h affected the judgment ability more than the response speed. Conclusion: Sleep deprivation might lead to compromised performance of medical students in examinations.
DISTRIBUTION , SPREAD AND PRESENT STATUS OF Mimosa pigra L . ( MIMOSACEAE ) IN PENINSULA MALAYSIA : 1980-2004

Mimosa pigra L. (Mimosaceae), a noxious semi-aquatic woody plant and once considered to be an important invasive species in the early 1980s has now spread through out Peninsula Malaysia. This happened despite an effort to control the spread through the introduction of two biological control agents, Carmenta mimosa and Acanthoscelides puniceus between 1992 and 1994. To assess the present status of Mimosa spread, a survey was conducted in 2004, which covered six habitat types namely a construction site, roadside, riverbank, reservoir, plantation and forest reserve. A total of 53 from 80 sites visited have been recorded with Mimosa populations. Five habitat types were more prone to be invaded by Mimosa whilst forest reserves were found to be non-susceptible to Mimosa invasion. Three conclusions can be drawn from this survey; (1) Soil contaminated with Mimosa seeds used in construction industries is likely to be the main dispersal agent, (2) Mimosa infestation has never been dealt successfully at its earliest establishment phase, and (3) the invasion is no longer restricted to wetland habitat but has spread into various types of landscapes and terrestrial ecosystems.
Plasmid-mediated quinolone resistance due to qnrB5 and qnrS1 genes in Salmonella enterica serovars Newport, Hadar and Saintpaul isolated from turkey meat in Denmark.

1. Robicsek A, Jacoby GA, Hooper DC. The worldwide emergence of plasmid-mediated quinolone resistance. Lancet Infect Dis 2006; 6: 629–40. 2. Robicsek A, Strahilevitz J, Sahm DF et al. qnr prevalence in ceftazidime-resistant Enterobacteriaceae isolates from the United States. Antimicrob Agents Chemother 2006; 50: 2872–4. 3. Park CH, Robicsek A, Jacoby GA et al. Prevalence in the United States of aac(60)-Ib-cr encoding a ciprofloxacin-modifying enzyme. Antimicrob Agents Chemother 2006; 50: 3953–5. 4. Park YJ, Yu JK, Lee S et al. Prevalence and diversity of qnr alleles in AmpC-producing Enterobacter cloacae, Enterobacter aerogenes, Citrobacter freundii and Serratia marcescens: a multicentre study from Korea. J Antimicrob Chemother 2007; 60: 868–71. 5. Clinical and Laboratory Standard Institute. Performance Standards for Antimicrobial Susceptibility Testing: Fifteenth Informational Supplement M100-S15. CLSI, Wayne, PA, USA, 2005. 6. Paterson DL, Hujer KM, Hujer AM et al. Extended-spectrum b-lactamases in Klebsiella pneumoniae bloodstream isolates from seven countries: dominance and widespread prevalence of SHVand CTX-M-type b-lactamases. Antimicrob Agents Chemother 2003; 47: 3554–60.
Serum resistance in Haemophilus parasuis SC096 strain requires outer membrane protein P2 expression.

Haemophilus parasuis outer membrane protein P2 (OmpP2), the most abundant protein in the outer membrane, has been identified as an antigenic protein and a potential virulence factor. To study the precise function of OmpP2, an ompP2-deficient mutant (ΔompP2) of a H. parasuis serovar 4 clinical strain SC096 was constructed by a modified natural transformation system. Compared with the wild-type SC096 strain, the ΔompP2 mutant showed a pronounced growth defect and exhibited significantly greater sensitivity to the bactericidal action of porcine and rabbit sera, whereas the complemented strain could restore the growth and serum resistance phenotypes. The results indicated that H. parasuis OmpP2 from SC096 strain is an important surface protein involved in serum resistance.
The impact of pharmacogenetics of metabolic enzymes and transporters on the pharmacokinetics of telmisartan in healthy volunteers

Objective Telmisartan is mainly taken up into the liver by organic anion transporting polypeptide (OATP) 1B3, conjugated with glucuronate, and excreted into the bile. We investigated the relationship between genotypes of metabolizing enzymes and transporters and pharmacokinetics of telmisartan in clinical study. We also checked which enzymes are responsible for telmisartan glucuronidation. Materials and methods We collected blood samples from 57 healthy volunteers who had participated in a clinical trial of telmisartan and examined the relationship between 14 mutations in six transporters/metabolic enzymes and pharmacokinetics of telmisartan. We also performed an in-vitro glucuronidation assay with recombinant uridine 5′-diphospho-glucuronosyltransferases isoforms and human liver microsomes. Results In the clinical study, area under the plasma concentration–time curve value from time zero to infinity, of telmisartan in heterozygotes of SLCO1B3 (encoding protein: OATP1B3) rs11045585 tended to be larger than that in homozygotes of wild-type alleles. Unexpectedly, 19 heterozygotes of UGT1A1*28, whose function was decreased, significantly increased its oral clearance compared with homozygotes of UGT1A1*1 alleles (1090±690 vs. 620±430 ml/min/body). Metabolic clearance of telmisartan in human liver microsomes obtained from individuals with UGT1A1*28/*28 was higher compared with that of UGT1A1*1/*1 (168±33 vs. 93.3±27.3 &mgr;l/min/mg protein). Although telmisartan was metabolized by multiple UGT isoforms, in-vitro experiments revealed that UGT1A3 was estimated to be predominantly involved in telmisartan glucuronidation in human hepatocytes. Conclusion UGT1A1*28 was thought to enhance the protein expression of UGT1A3 as reported most recently (Riedmaier et al. Clin Pharmacol Ther 2010; 87:65–73) and thereby increase glucuronidation activity of telmisartan and decrease the plasma concentration of telmisartan.
[Studies on chemical constituents of Euphorbia sororia].

OBJECTIVE To study the chemical constituents of the aerial parts of Euphorbia sororia. METHOD Isolation and purification were carried out by silica gel and Sephadex LH -20 column chromatographies. Compounds were identified by physicochemical properties and spectral analysis. RESULT Ten compounds were isolated from the plant . Their structures were identified as kaempferol (1), scopoletin (2) , kaempferol 3-O-glucopyranoside (3) , quercetin (4) , vanillic acid (5) , E-p-hydroxycinnamic acid (6) , protocatechuic acid (7), 6, 7-dihydroxycoumarin (8), beta-sitosterol (9), and daucosterol (10) , respectively. CONCLUSION All the above compounds were isolated from the plant for the first time.
How Organizational Identity Affects Team Functioning: The Identity Instrumentality Hypothesis

How does organizational identity affect team functioning? We articulate and test an identity instrumentality hypothesis that suggests that organizational identity (1) directly predicts those aspects of team functioning that enable, and are instrumental in, employees’ fulfillment of their identity with the organization; and (2) indirectly predicts other aspects of team functioning not instrumental to organizational identity fulfillment. Underlying this hypothesis is the idea that some aspects of team functioning, such as team performance and cooperative team behaviors, are important to individuals’ fulfillment of their organizational identity because the implications of these behaviors extend beyond the immediacy of the team, whereas other aspects of team functioning (e.g., team affect) are not instrumental to organizational identity fulfillment because they are relevant mainly within the team context. We test the identity instrumentality hypothesis by using meta-analytic path analysis conducted on effect estimates obtained from 132 independent studies (total N = 28,024) of organizational and team identity. As hypothesized, we find that whereas team identity fully mediates the relationship between organizational identity and team affective constructs (i.e., aspects of team functioning not instrumental to the fulfillment of organizational identity), organizational identity uniquely and directly affects cooperative team behavior and team performance, which are those aspects of team functioning that are instrumental to the fulfillment of organizational identity.
Fibronectin receptor of human macrophages recognizes the sequence Arg- Gly-Asp-Ser

When cultured human monocytes (MO) were spread on fibronectin (Fn)- coated surfaces, C3 receptors on the MO exhibited markedly enhanced capacity to promote phagocytosis. The activation of C3 receptors by Fn was mediated by a receptor that recognizes a sequence, Arg-Gly-Asp-Ser (RGDS), present in the cell-binding domain of Fn. Soluble, RGDS- containing peptides inhibited the activation of C3 receptors caused by surface-bound Fn, and surface-bound, RGDS-containing peptides themselves caused activation of the C3 receptors of attached MO. Although soluble, RGDS-containing peptides bound to Fn receptors, such monovalent ligation was insufficient to activate C3 receptors.
Effects of prostaglandin on the reproductive performance of dairy cows

A single injection of a synthetic analogue of prostaglandin F2 alpha (fenprostalene; Syntex) on the day of calving or between days 14 and 21 after calving did not affect the calving to first service interval, the number of services per conception or the conception rate of dairy cows. In a second trial, cows calved more than 45 days were injected once weekly with prostaglandin F2 alpha (dinoprost; Upjohn) or fenprostalene until served at the first detected oestrus. The calving to first service interval and the conception rate were not affected. Following injection of either prostaglandin, the spread in the pattern of onset of oestrus and the range in the proportion of cows (75 to 98 per cent) seen in oestrus within seven days were similar. This variation in the time of onset of oestrus after the administration of prostaglandin precludes limiting oestrus detection to four or five days per week, and is a major limitation to the use of prostaglandins in breeding programmes in dairy cows.
Intervention strategies to reduce musculoskeletal injuries associated with handling patients: a systematic review

Aims: To report, analyse, and discuss the results of a systematic review looking at intervention strategies to reduce the risk factors associated with patient handling activities. Methods: A search strategy was devised to seek out research between 1960 and 2001. Inclusion/exclusion criteria limited the entry of papers into the review process. A checklist was selected and modified to include a wide range of study designs. Inter-rater reliability was established between six reviewers before the main review process commenced. Each paper was read by two reviewers and given a quality rating score, with any conflicts being resolved by a third reviewer. Papers were grouped by category: multifactor, single factor, and technique training based interventions. Results: A total of 2796 papers were found, of which 880 were appraised. Sixty three papers relating to interventions are reported in this paper. The results are reported as summary statements with the associated evidence level (strong, moderate, limited, or poor). Conclusion: There is strong evidence that interventions predominantly based on technique training have no impact on working practices or injury rates. Multifactor interventions, based on a risk assessment programme, are most likely to be successful in reducing risk factors related to patient handling activities. The seven most commonly used strategies are identified and it is suggested that these could be used to form the basis of a generic intervention programme, with additional local priorities identified through the risk assessment process. Health care providers should review their policies and procedures in light of these findings.
A nor-diterpene from Salvia sahendica leaves

Abstract Phytochemical investigation of n-hexane extract of Salvia sahendica by normal phase column chromatography resulted in the isolation of six compounds. Structures were established by 1D and 2D NMR spectroscopy, and HRMS, as a new norditerpene 1, and known terpenoids, sclareol (2), oleanolic acid (3), β-sitosterol (4), salvigenin (5) and 3α-hydroxy-11α,12α-epoxyoleanan-28,13β-olide (6). The absolute configuration of 1 was confirmed by a combination of X-ray single crystal analysis and electronic circular dichroism spectroscopy. In vitro cytotoxic activity on breast cancer cell line (MDA-MB-231) and also the antimicrobial activity of the pure compounds were tested against Staphylococcus aureus, Bacilus cereus and Escherichia coli.
The role of estrogen in bipolar disorder, a review

Abstract Background: It appears that the female reproductive events and hormonal treatments may impact the course of bipolar disorder in women. In particular, childbirth is known to be associated with onset of affective episodes in women with bipolar disorder. During the female reproductive events the sex hormones, e.g. estrogen, are fluctuating and particularly postpartum there is a steep fall in the levels of serum estrogen. The role of estrogen in women with bipolar disorder is, however, not fully understood. Aim: The main objective of this review is to evaluate the possible relation between serum estrogen levels and women with bipolar disorder including studies of the anti manic effects of the selective estrogen receptor modulator tamoxifen. Method: A systematically literature search on PubMed was conducted: two studies regarding the connection between serum estrogen levels and women with bipolar disorder were identified. Furthermore, four studies were found concerning the antimanic effects of tamoxifen. Results: Both studies in the estrogen studies showed very low levels of estrogen in women with postpartum psychosis and significant improvement of symptoms after treatment with estrogen. The four tamoxifen studies found that tamoxifen was effective in producing antimanic effects. Conclusion: These results indicate that estrogen fluctuations may be an important factor in the etiology of bipolar disorder and it is obvious that more research on this topic is needed to clarify the role of estrogen in women with bipolar disorder.
Evaluation of vaccine seroresponse rates and adverse event rates through Bayesian and frequentist methods

In the evaluation of vaccine seroresponse rates and adverse reaction rates, extreme test results often occur, with substantial adverse event rates of 0% and/or seroresponse rates of 100%, which has produced several data challenges. Few studies have used both the Bayesian and frequentist methods on the same sets of data that contain extreme test cases to evaluate vaccine safety and immunogenicity. In this study, Bayesian methods were introduced, and the comparison with frequentist methods was made based on practical cases from randomized controlled vaccine trials and a simulation experiment to examine the rationality of the Bayesian methods. The results demonstrated that the Bayesian non-informative method obtained lower limits (for extreme cases of 100%) and upper limits (for extreme cases of zero), which were similar to the limits that were identified with the frequentist method. The frequentist rate estimates and corresponding confidence intervals (CIs) for extreme cases of 0 or 100% always equaled and included 0 or 100%, respectively, whereas the Bayesian estimations varied depending on the sample size, with none equaling zero or 100%. The Bayesian method obtained more reasonable interval estimates of the rates with extreme data compared with the frequentist method, whereas the frequentist method objectively expressed the outcomes of clinical vaccine trials. The two types of statistical results are complementary, and it is proposed that the Bayesian and frequentist methods should be combined to more comprehensively evaluate clinical vaccine trials.
Group key exchange protocols withstanding ephemeral-key reveals

When a group key exchange protocol is executed, the session key is typically extracted from two types of secrets: long-term keys (for authentication) and freshly generated (often random) values. The leakage of this latter so-called ephemeral keys has been extensively analysed in the 2-party case, yet very few works are concerned with it in the group setting. The authors provide a generic group key exchange construction that is strongly secure, meaning that the attacker is allowed to learn both long-term and ephemeral keys (but not both from the same participant, as this would trivially disclose the session key). Their design can be seen as a compiler, in the sense that it builds on a 2-party key exchange protocol which is strongly secure and transforms it into a strongly secure group key exchange protocol by adding only one extra round of communication. When applied to an existing 2-party protocol from Bergsma et al., the result is a 2-round group key exchange protocol which is strongly secure in the standard model, thus yielding the first construction with this property.
Hamiltonian magnetic reconnection with parallel electron heat flux dynamics

We analyse, both analytically and numerically, a two-dimensional six-field fluid model for collisionless magnetic reconnection, accounting for temperature and heat flux fluctuations along the direction of the magnetic guide field. We show that the model possesses a Hamiltonian structure with a non-canonical Poisson bracket. This bracket is characterized by the presence of six infinite families of Casimirs, associated with Lagrangian invariants. This reveals that the model can be reformulated as a system of advection equations, thus generalizing previous results obtained for Hamiltonian isothermal fluid models for reconnection. Numerical simulations indicate that the presence of heat flux and temperature fluctuations yields slightly larger growth rates and similar saturated island amplitudes, with respect to the isothermal models. For values of the sonic Larmor radius much smaller than the electron skin depth, heat flux fluctuations tend to be suppressed and temperature fluctuations follow density fluctuations. Increasing the sonic Larmor radius results in an increasing fraction of magnetic energy converted into heat flux, at the expense of temperature fluctuations. In particular, heat flux fluctuations tend to become relevant along the magnetic island separatrices. The qualitative structures associated with the electron field variables are also reinterpreted in terms of the rotation of the Lagrangian invariants of the system.
Quality of Life in Relation to Mood, Coping Strategies, and Dyskinesia in Parkinson's Disease

Given the variability of the results found in the literature, the current study is a step toward better clarifying the influence of motor and nonmotor factors on quality of life in Parkinson's disease. A total of 135 participants with Parkinson's disease were selected. Semistructured interviews were carried out, after which their mental and cognitive states were assessed using different scales (MINI, MADRS, EHD, HAMA). Finally, all participants completed 3 self-report questionnaires: 2 assessing coping strategies (WCC, CHIP) and 1, quality of life (Parkinson's disease questionnaire-39). It appears that the presence of dyskinesia, depression, and anxiety were linked to a poor quality of life. Interestingly, some different coping strategies, namely diversion as well as emotional strategies, were associated with a poor quality of life. These results encourage us to develop interventions focused on coping strategies and tailored to the emotional and clinical characteristics of each patient.
A new second-order accurate time discretization method for the nonlinear cubic Schrödinger equation

A new second-order accurate semi-analytical time discretization method is introduced for the numerical solution of the one-dimensional nonlinear cubic Schrödinger equation. This method is based on the combination of the method of lines, Crank–Nicolson method, Newton method and Lanczos’ Tau method. It is a self-starting averaged two-time-level scheme that has proved to be stable, accurate and energy conservative for long time integration periods. At each time level, approximate solutions are sought on a segmented spatial interval as finite expansions in terms of a given orthogonal polynomial basis mapped appropriately onto each spatial subsegment. We have carried out numerical simulation concerning several cases for the propagation, collision and the bound states of solitons. Accurate results have been obtained using Chebyshev and Legendre polynomials. These results are well comparable with other published results obtained by the use of various standard numerical methods.
Treatment of hyperthyroidism in pregnancy and birth defects.

CONTEXT Clinical hyperthyroidism is not uncommon in pregnancy, with a reported prevalence of 0.1 to 0.4%. The available antithyroid drugs are propylthiouracil and methimazole/carbimazole. OBJECTIVES In this report we examined the association of both drugs with congenital malformations using data from the International Clearinghouse for Birth Defects Surveillance and Research. DESIGN The study used a case-affected control analysis and included 18,131 cases with malformations and reported first-trimester exposure to medication. A total of 127 subjects were born to mothers with known first-trimester antithyroid drug exposure. RESULTS Among the 52 groups of malformations that were analyzed, situs inversus ± dextrocardia, isolated unilateral kidney a/dysgenesis, and cardiac outflow tract defects were associated with prenatal exposure to propylthiouracil based on three, two, and five cases, respectively. Prenatal exposure to methimazole/carbimazole was significantly associated with choanal atresia, omphalocele, and total situs inversus ± dextrocardia (P < 0.01). CONCLUSIONS Further studies are required to exhaustively evaluate the associations between propylthiouracil and birth defects because of the low number, the lack of biological plausibility, and the possibility of underdiagnosis. Association between methimazole/carbimazole exposure and omphalocele and choanal atresia is consistent with previous reports and definitely suggests that these malformations could be part of a specific, even if rare, embryopathy.