Miracle-dz/UniFAR-FTUs huggingface dataset:
THE INFLUENCE OF REGIONAL DIALECT VARIATION ON RACE CATEGORIZATION

Socio-ethnic and regional group membership influence segmental and suprasegmental talker characteristics. Listeners can use acoustic-phonetic variation to identify a talker's socio-ethnic and regional dialect; often with above chance accuracy. However, the interaction between socio-ethnic identity and regional dialect in speech perception has rarely been evaluated. This work examined how regional dialect variation influences socio-ethnic perceptions of race within the United States. Black and White talkers from two distant North Carolina communities produced /hVd/ words. Listeners unfamiliar with the dialect completed a twoalternative forced-choice race identification task. An interaction was observed between talker socio-ethnic racial identity and regional dialect. Listeners' identification of White talkers was well above chance for both communities. Listeners' identification of Eastern North Carolina Black talkers, participants of the African American Vowel Shift, was above chance; but identification of Black Western North Carolina talkers, participants of the Southern Vowel Shift, was at chance.
The Communication of Intellectual Capital – Prevalence and relationship with Organizational Performance

While intellectual capital (IC) as an asset is long noted, one area that has begun to attract attention is the communication of IC. The past decade of increasing global competition and economic downturns have enhanced the importance of the communication of IC, in particular, how IC supports organizational performance (OP). Current literature on the communication of IC is limited to reporting metrics, which does not provide sufficient insights on OP. Yet, the need for the communication of IC is growing globally as investors are demanding for more non-financial information to reflect organization’s sustainability. Hence, the objectives of this study are three-fold. First is to ascertain the prevalence of the communication of IC, where past studies have reported low occurrence. Secondly, the study aims to examine the communication of IC in terms of content; and finally, to investigate the correlation of the communication of IC with OP. The dataset used in this study was drawn from annual reports and supplementary corporate disclosure (ARS) published for FYE2011 in English by 299 banks listed on the stock exchanges globally. The communication of IC was reviewed from three angles, namely human capital, relational capital and structural capital; and OP encompasses business continuity, risk management and organizational productivity. Content analysis was used to evaluate the communication of IC and to highlight nuances and trends. Findings showed that the communication of IC was prevalent in more than half of the banks in the dataset, where the communication of Human Capital content was most widely reported. Smaller banks, in particular, were found to be lacking in the communication of IC. Three peculiarities were also identified, namely inclusion of information on women, importance of training to organizational productivity, and extensiveness of risk management processes in banks. The significance of this study lies in its effort to highlight relevance of the communication of IC from the perspective of IC components and its correlation to OP.
Sheffield Economic Research Paper Series SERP Number : 2007003

Estimates of over education from different ethnic groups are presented using a new method of calculating over education and data from the UK Labour Force Survey. Calibrated against existing mean methods, the new approach leads to lower levels of over education for men and women. While the overall extent of over education has similarities with earlier studies, the differences between ethnic groups are far less than those found in some studies and fall even further when we control for other productivity related differences. Gender differences can be partially explained by differences in working part-time, whereas some ethnic differences are exacerbated slightly by being temporarily over educated, as well as by differences in the subject of degree.
The Empire is Dead, Long Live the Empire! Long�?Run Persistence of Trust and Corruption in the Bureaucracy

Do empires affect attitudes towards the state long after their demise? We hypothesize that the Habsburg Empire with its localized and well-respected administration increased citizens’ trust in local public services. In several Eastern European countries, communities on both sides of the long-gone Habsburg border have been sharing common formal institutions for a century now. Identifying from individuals living within a restricted band around the former border, we find that historical Habsburg affiliation increases current trust and reduces corruption in courts and police. Falsification tests of spuriously moved borders, geographic and pre-existing differences, and interpersonal trust corroborate a genuine Habsburg effect.
Impacto de las advertencias con pictogramas en las cajetillas de cigarrillos en México: resultados de una encuesta en fumadores de Guadalajara

OBJETIVO: Mostrar el efecto de las primeras advertencias sanitarias (AS) con pictogramas en Mexico. MATERIAL Y METODOS: Encuesta transversal en una muestra representativa de 1 765 adultos fumadores de Guadalajara, Mexico (2010). Se estimaron modelos logisticos para determinar la asociacion entre el reconocimiento de las AS con pictogramas y las variables que indican el impacto de las mismas. RESULTADOS: 58% de la poblacion indico haber comprado una cajetilla con AS con pictogramas. Estos fumadores expuestos reportaron pensar con mayor frecuencia en los danos que causa fumar (34 contra 25% p=0.003) y pensar en dejar de fumar (23 contra 14% p=0.001). Se observo una mayor aceptacion de las AS como medio para comunicar informacion importante al fumador (93 contra 87% p<0.001) asi como mayor aceptacion de que el gobierno comunica bien sobre los danos a la salud por fumar (68 contra 55% p<0.001). CONCLUSION: Las AS con pictogramas han logrado aumentar el conocimiento sobre los danos que provoca el tabaco. La recomendacion es seguir desarrollando y mejorando esta intervencion para coadyuvar a lograr una poblacion informada de los riesgos del tabaco.
Domain Adaptation with BERT-based Domain Classification and Data Selection

The performance of deep neural models can deteriorate substantially when there is a domain shift between training and test data. For example, the pre-trained BERT model can be easily fine-tuned with just one additional output layer to create a state-of-the-art model for a wide range of tasks. However, the fine-tuned BERT model suffers considerably at zero-shot when applied to a different domain. In this paper, we present a novel two-step domain adaptation framework based on curriculum learning and domain-discriminative data selection. The domain adaptation is conducted in a mostly unsupervised manner using a small target domain validation set for hyper-parameter tuning. We tested the framework on four large public datasets with different domain similarities and task types. Our framework outperforms a popular discrepancy-based domain adaptation method on most transfer tasks while consuming only a fraction of the training budget.
Demographic and utilisation changes for rural and remote populations—subacute admitted care

Over the last 20 years Jim Pearse has been an active participant and leader in health policy issues and research both within and outside of government. He established Health Policy Analysis Pty Ltd in 1993, a consulting firm focusing on health policy, analysis of health data for decision making, performance indicators, and health economics. Since 1993, Health Policy Analysis has undertaken a large number of consulting projects for the Commonwealth and state government, and non‐government clients, including projecting demand for health services, costing, development of funding models and evaluation of health services.
OTT_A_199452 7785..7790

*These authors contributed equally to this work Abstract: Therapy for leptomeningeal metastases (LM) from non-small cell lung cancer (NSCLC) is challenging, and conventional treatments have little impact on the disease course. We report three cases that were definitively diagnosed as LM from NSCLC with a mutation of epidermal growth factor receptor (EGFR) L858R. The systemic therapies of chemotherapy, local radiotherapy, and early generation tyrosine kinase inhibitors (TKIs) were implemented but ineffective. Three patients were treated with the third-generation TKI osimertinib at 80 mg daily, despite their different detection levels of T790M in the cerebrospinal fluid (CSF) and plasma, and achieved symptomatic remission, a decline of carcinoembryonic antigen (CEA) levels, and stable lesions. After the progression of LM, osimertinib at 160 mg daily further lengthened the quality of life and survival time of patients without any notable side effects during treatment. Recent related studies and our cases indicate that osimertinib has a positive effect on LM from EGFR-mutant NSCLC, regardless of T790M status.
Analysis of community structures in anaerobic processes using a quantitative real-time PCR method

The methanogenic community structures of four different anaerobic processes were characterized using a quantitative real-time PCR with group-specific primer and probe sets targeting the 16S rRNA gene (rDNA). The group specific primer and probe sets were developed and used to detect the orders Methanosarcinales, and the families Methanosarcinaceae and Methanosaetaceae. Two separate sets targeting the domains Archaea and Bacteria were also used. Each microbial population in different anaerobic processes was determined and the relative abundance in the system was compared with each other. Dominant methanogenic populations and the community structures in the processes were varied by hydraulic retention time and acetate concentration. This indicates that the real-time PCR method with the primer and probe sets is a promising tool to analyze community structures in anaerobic processes.
Histopathological characteristics ofendometrial biopsies in the Igbos of Nigeria

Background: Geographical approach in medical research has revealed important patterns of diseases. Many ethnic groups remained to be explored worldwide. Objective: To study the histopathological characteristics of endometrial biopsies in the Igbos of Nigeria. Methodology: A retrospective analysis of the records of the histopathological department of the National Orthopaedic Hospital, Enugu between January and December 2014. The sociodemographic characteristics of the patients, clinical summaries and the histological diagnosis on endometrial tissues were extracted from the records of the histopathology department. Results: A total of 330 endometrial tissue samples were analysed. The age range was 20-75 years with a mean of 36.2±14 years. The parity ranged from 0-9±4. Secretory endometrium (56.1%), products of conception (7.6%) and proliferative endometrium (5.2%) were the commonest histopathological diagnosis whereas infertility (61.2%) was the commonest indication for requesting for endometrial biopsy. Conclusion: There are recognizable histopathological patterns of endometrial pathologies amongst the Igbos. These patterns are not at great variance with those in other black communities in the developing parts of Africa and the rest of the world.
What characterizes the culture of a relationship-focused organization applying a customer intimacy strategy ?

This paper aims to answer the question: What characterizes the culture of a relationshipfocused firm applying a customer intimacy strategy? The theoretical lens utilized enables us to focus our attention on the inside of firms, thus resources and assets embodied in, for example, the people and culture that underlie any advantages on the product market. Findings from this study show that a successful outcome of the firm’s strategy is attributed to its culture; its commitment to continuous improvement is considered as a point of parity. The strategy’s point of difference is the passion and behaviour of people in the firm toward their customers and each other. The findings show that organizational learning is a key to future organizational success, and the ability to learn is a priority for organizations that wish to compete effectively. Conclusions and implications drawn from the study are that the strategy provides a sense of unity, direction and purpose. Moving from a sales philosophy to a customer intimacy strategy requires an appreciation of the current and changing needs of customers and organizations that continuously fine-tune the strategy’s compatibility with corresponding values in the firm’s business culture, and maintain an informed workforce that is aligned with the strategy, working together, and sharing knowledge to help the strategy succeed. This paper contributes to existing knowledge by showing how cultural reasoning can lead to useful insights for practising managers, particularly with regard to strategies for dealing with a firm’s internal and external environments.
Antimicrobial Property of Sodium Alginate/TiO2 Nanocomposite Film

Food poisoning outbreaks are commonly caused by bacterial contamination. These incidents can be minimized by using antimicrobial films that are suitable for use as packaging material. These films can be made by immobilizing an antibacterial agent to a non-toxic polymer matrix. Titanium dioxide (TiO2), when irradiated with ultraviolet light, produces free radicals capable of killing bacteria. Sodium alginate (SA) is an edible polymer taken from brown algae. Both TiO2 and SA are approved by the U.S. Food and Drug Administration as an additive in food. Therefore, composites made from SA and TiO2 are considered safe. SA/TiO2 nanocomposite films can be activated by both fluorescent and black light lamps. As evidenced by the percent color removal of methylene blue, the photocatalytic activity appeared to be higher when exposed to black light. SA/TiO2 composite films were exposed to fluorescent and black light lamps for 5 h in the presence of Escherichia coli and Staphylococcus aureus. Under fluorescent lamps, the photocatalytic activity of the SA/TiO2 composite films was enough to at least inhibit the proliferation of both bacteria. However, exposure of the 5% SA/TiO2 composite film to black light resulted to a 0 log count for both bacteria. These results showed that SA/TiO2 composite films can therefore be used in the food industry as an antibacterial film. Philippine Journal of Science 147 (3): 545-550, September 2018 ISSN 0031 7683 Date Received: 22 Feb 2018
OPTA—malnutrition in chronic renal failure

Protein–energy malnutrition (PEM) is common among patients with advanced chronic kidney disease (CKD stages 4 and 5) and is associated with an increased risk of morbidity and mortality. Early recognition and treatment of malnutrition is essential to improve the outcome of patients with advanced CKD and those undergoing maintenance peritonealdialysis and haemodialysis treatment.
The relationships between marketing mix, brand equity, lifestyle and attitude on a consumer’s private product brand purchasing decision

In a 2018 study, 85% of the American consumers surveyed stated they trusted private brand products at least as much as national brands. In both Asia and Thailand, the importance of private brands is also increasing. Therefore, the researchers undertook a study to investigate the sample group of 1,000 Thai Tesco Lotus and Big C retail shoppers about their opinions concerning the importance of the store’s marketing mix (MM), brand equity (BE), their lifestyle (LS), and their attitude (AT) towards their final purchase decision. LISREL 9.1 was used to conduct both a confirmatory factor analysis [CFA] and a structural equation model [SEM] to analyze the study’s six hypotheses and their interrelationships. From the SEM analysis it was determined that the most important causal variables influencing PDPD were BE, AT, MM, and LS, which had total effect values of . 61, . 23. , . 22, and . 17, respectively.
Tensile Properties and Fracture Behavior of 6061/Al2o3 Metal Matrix Composites Fabricated by Low Pressure Die Casting Process

In the present work, the low-pressure die casting process has been implemented to fabricate 6061/ Al2O3 metal matrix composites. This process avoids the transport of clustered Al2O3 particles into the die cavity. The yield strength and fracture strength increase with increase in volume fraction of Al2O3 , whereas ductility of 6061/Al2O3 composites decreases. The skewness in the tensile properties is reduced owing to the solution treatment of the 6061/ Al2O3 composites. The formation of intermetallic particles MgAl2O4, Al5Cu2Mg8Si6 or Al4CuMg5Si4 was also observed in the composites. The fracture mode is ductile in nature.
Lessons to be learned from partnerships with families: a case study

The following case study describes a therapeutic intervention with a seven-year-old child with diabetes and her family, at the centre of which was the partnership between two professionals, and between the family and the team. The work was informed by systemic models of family therapy and elements of cognitive behavioural therapy as well as best practice in working with families and young people with type 1 diabetes. The collaborative nature of multidisciplinary teams within paediatric diabetes, facilitates best outcomes for families of young children with type 1 diabetes and promotes continuity of care. The case study pays particular regard to the way in which practice is informed and evaluated by theory. Thus, relevant literature is signposted throughout the article, reflecting our use of documented strategies and issues that have been discussed further (and in greater depth) elsewhere.
DYRK1A Overexpression Alters Cognition and Neural-Related Proteomic Pathways in the Hippocampus That Are Rescued by Green Tea Extract and/or Environmental Enrichment

Down syndrome (DS), caused by trisomy of chromosome 21, is the most common genetic cause of intellectual disability. We recently discovered that green tea extracts containing epigallocatechin-3-gallate (EGCG) improve cognition in mice transgenic for Dyrk1a (TgDyrk1A) and in a trisomic DS mouse model (Ts65Dn). Interestingly, paired with cognitive stimulation, green tea has beneficial pro-cognitive effects in DS individuals. Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1A (DYRK1A) is a major candidate to explain the cognitive phenotypes of DS, and inhibiting its activity is a promising pro-cognitive therapy. DYRK1A kinase activity can be normalized in the hippocampus of transgenic DYRK1A mice administering green tea extracts, but also submitting the animals to environmental enrichment (EE). However, many other mechanisms could also explain the pro-cognitive effects of green tea extracts and EE. To underpin the overall alterations arising upon DYRK1A overexpression and the molecular processes underneath the pro-cognitive effects, we used quantitative proteomics. We investigated the hippocampal (phospho)proteome in basal conditions and after treatment with a green tea extract containing EGCG and/or EE in TgDyrk1A and control mice. We found that Dyrk1A overexpression alters protein and phosphoprotein levels of key postsynaptic and plasticity-related pathways and that these alterations were rescued upon the cognitive enhancer treatments.
Intra- and Post-match Time-Course of Indicators Related to Perceived and Performance Fatigability and Recovery in Elite Youth Soccer Players

Purpose Our aims were to examine (i) the internal load during simulated soccer match-play by elite youth players; and (ii) the time-course of subsequent recovery from perceived and performance fatigability. Methods Eleven male youth players (16 ± 1 years, 178 ± 7 cm, 67 ± 7 kg) participated in a 2 × 40-min simulated soccer match, completing 30 rounds (160 s each) with every round including multidirectional and linear sprinting (LS20m), jumping (CMJ) and running at different intensities. During each round, LS20m, CMJ, agility, heart rate (HR), oxygen uptake (VO2), energy expenditure (EE), substrate utilization and perceived exertion RPE were assessed. In addition, the blood level of lactate (Lac) was obtained after each of the five rounds. Creatine kinase (CK) concentration, maximal voluntary isometric knee extension and flexion, CMJ, number of skippings in 30 s, and subjective ratings on the Acute Recovery and Stress Scale (ARSS) were examined before and immediately, 24 and 48 h after the simulation. Results During the game %HRpeak (p < 0.05, d = 1.08), %VO2peak (p < 0.05; d = 0.68), Lac (p < 0.05, d = 2.59), RPEtotal (p < 0.05, d = 4.59), and RPElegs (p < 0.05, d = 4.45) all increased with time during both halves (all p < 0.05). Agility improved (p < 0.05, d = 0.70) over the time-course of the game, with no changes in LS20m (p ≥ 0.05, d = 0.34) or CMJ (p ≥ 0.05, d = 0.27). EE was similar during both halves (528 ± 58 vs. 514 ± 61 kcal; p = 0.60; d = 0.23), with 62% (second half: 65%) carbohydrate, 9% (9%) protein and 26% (27%) fat utilization. With respect to recovery, maximal voluntary knee extension (p ≥ 0.05, d = 0.50) and flexion force (p ≥ 0.05, d = 0.19), CMJ (p ≥ 0.05, d = 0.13), number of ground contacts (p ≥ 0.05, d = 0.57) and average contact time (p ≥ 0.05, d = 0.39) during 30-s of skipping remained unaltered 24 and 48 h after the game. Most ARSS dimensions of load (p < 0.05, d = 3.79) and recovery (p < 0.05, d = 3.22) returned to baseline levels after 24 h of recovery. Relative to baseline values, CK was elevated immediately and 24 h after (p < 0.05, d = 2.03) and normalized 48 h later. Conclusion In youth soccer players the simulated match evoked considerable circulatory, metabolic and perceptual load, with an EE of 1042 ± 118 kcal. Among the indicators of perceived and performance fatigability examined, the level of CK and certain subjective ratings differed considerably immediately following or 24–48 h after a 2 × 40-min simulated soccer match in comparison to baseline. Accordingly, monitoring these variables may assist coaches in assessing a U17 player’s perceived and performance fatigability in connection with scheduling training following a soccer match.
Targeted Therapies for Pediatric AML: Gaps and Perspective

Acute myeloid leukemia (AML) is a hematopoietic disorder characterized by numerous cytogenetic and molecular aberrations that accounts for ~25% of childhood leukemia diagnoses. The outcome of children with AML has increased remarkably over the past 30 years, with current survival rates up to 70%, mainly due to intensification of standard chemotherapy and improvements in risk classification, supportive care, and minimal residual disease monitoring. However, childhood AML prognosis remains unfavorable and relapse rates are still around 30%. Therefore, novel therapeutic approaches are needed to increase the cure rate. In AML, the presence of gene mutations and rearrangements prompted the identification of effective targeted molecular strategies, including kinase inhibitors, cell pathway inhibitors, and epigenetic modulators. This review will discuss several new drugs that recently received US Food and Drug Administration approval for AML treatment and promising strategies to treat childhood AML, including FLT3 inhibitors, epigenetic modulators, and Hedgehog pathway inhibitors.