Miracle-dz/UniFAR-FTUs huggingface dataset:
ADHD and Vision Problems in the National Survey of Children’s Health

Purpose To compare the prevalence of attention deficit/hyperactivity disorder (ADHD) in children with normal vision and with vision problems not correctable with glasses or contact lenses (vision problems) as determined by parent report in a nationwide telephone survey. Methods This cross-sectional study included 75,171 children without intellectual impairment aged 4 to 17 years participating in the 2011 to 2012 National Survey of Children’s Health, conducted by the U.S. Centers for Disease Control and Prevention. Demographic information and information regarding vision and ADHD status were obtained by parent interview. Questions asked whether they had ever been told by a doctor or health care provider that the child had a vision problem not correctable with glasses or contact lenses, ADHD, intellectual impairment, or one of 13 other common chronic conditions of childhood. A follow-up question asked about condition severity. The main outcome measure was current ADHD. Results The prevalence of current ADHD was greater (p < 0.0001) among children with vision problems (15.6%) compared with those with normal vision (8.3%). The odds of ADHD compared with those of children with normal vision were greatest for those with moderate vision problems (odds ratio [OR], 2.6; 95% confidence interval [95% CI], 1.7 to 4.4) and mild vision problems (OR, 1.8; 95% CI, 1.1 to 2.9). Children with severe vision problems had similar odds of ADHD to those of children with normal vision perhaps because of the small numbers in this group (OR, 1.6; 95% CI, 0.8 to 3.1). In multivariable analysis adjusting for confounding variables, vision problems remained independently associated with current ADHD (OR, 1.8; 95% CI, 1.2 to 2.7). Conclusions In this large nationally representative sample, the prevalence of ADHD was greater among children with vision problems not correctable with glasses or contacts. The association between vision problems and ADHD remains even after adjusting for other factors known to be associated with ADHD.
In Vitro Study of the Deturgescence Ability of Cultivated Human Corneal Endothelial Cells

Purpose: To evaluate the efficiency of cultivated human corneal endothelial cells (HCECs) to dehydrate the cornea, using models of the posterior cornea, composed of artificial collagen mass (to represent corneal stroma) and equine collagen membranes (to represent Descemet membrane). Methods: HCECs were isolated from donor corneal rings and cultivated at 37°C in 5% CO2 and 95% humidified air. The study design included 4 different sets of models: in set 1, the HCECs were placed directly on the collagen mass complex; in set 2, HCECs were placed on a thin equine collagen membrane and laid over the collagen mass; in set 3, HCECs were placed on a thick equine collagen membrane laid over the collagen mass; and in set 4 (the control group), the hydrophilic collagen mass was left alone to interact with the nutritional medium. The minimum thickness of each sample was measured with optical coherence tomography directly before placement of cells and after exposure to the nutritional fluid for 48 hours. Results: After 2 days of exposure to the nutritional medium, the percentage decreases in thickness in “posterior cornea” models were 66% for set 1, 57% for set 2, and 13% set 3. In the control set, measurement of thickness after 2 days of exposure was not possible because of excessive fluid absorption. Conclusions: This in vitro study of HCECs showed that the dehydrating ability of HCECs is adversely affected by increased thickness of the artificial (Descemet) membrane. Further studies with similar models would aid better understanding of corneal diseases.
Dynasties and the Political Budget Cycle

Families often play a significant role in representative democracies. In this paper, we test the extent to which dynastic and non-dynastic leaders differ in their policy making. Our empirical analysis focuses on local politics in Italy, using a large sample of mayors and mayoral candidates in the period 1985–2012. We highlight that dynastic candidates have more successful political careers and that power is self-perpetuating, as those in power are more likely to establish a dynasty. We then test whether dynastic mayors enforce different policies than their non-dynastic counterparts. We find no effect on average spending, revenues or transfers. Conversely, we show that dynastic mayors increase spending and obtain higher transfers during the year prior to an election, especially when they are eligible to run for re-election. We discuss mechanisms that might explain this strategic behavior.
Do not feed the predators

This study investigates the prevalence and characteristics of papers published in popular predatory journals by South African academics in economic and management sciences. Our aim is to raise awareness and to deepen understanding of the predatory publishing phenomenon. We collected 728 recent (2013 to mid-2016) articles with South African authors in five popular in the field journals classified as ‘potential, possible, or probable predatory’ according to Beall’s list. Our data shows that publishing in these predatory journals is widespread across authors and universities. However, the data also shows that most of the authors only published once in these journals, suggesting that they perhaps mistakenly perceived the journals as being legitimate research outlets. We found evidence of low-quality publishing by the journals in our data, consistent with deficient peer review and copy editing processes. Thus, low-quality publishing was evident from spelling and grammar mistakes in the titles of articles, publishing the same paper twice in the same journal, so-called ‘salami slicing’, and the publishing of an article already published in another journal.
Clinicopathologic Findings and Treatment Outcome of Laryngectomized Patients with Laryngeal Cancer and Hypopharyngeal Cancer: An Experience in Thailand

Objective: To evaluate the clinicopathologic findings and treatment outcome in laryngectomized patients with laryngeal cancer and hypopharyngeal cancer. Materials and Methods: The authors retrospectively reviewed the medical records of 212 patients who had been newly diagnosed and treated with laryngectomy between January 2000 and December 2010. The age, gender, clinical manifestations, associated predisposing condition, tumor WHO grade, AJCC tumor stage, maximum tumor size, anatomical involvement, type of surgery, postoperative sequelae, treatment and therapeutic outcome were analyzed. Results: The present study included laryngeal cancer (n = 155) and hypopharyngeal cancer (n = 57). The patients’ age ranged from 38 to 84 years, with the mean age of 62.08±9.67 years. The common clinical presentations were hoarseness (73.6%), cervical lymphadenopathy (35.8%), sorethroat (22.2%), and odynophagia (14.6%). The laryngeal cancer commonly involves true vocal cord (86.5%), anterior commissure (65.8%), false vocal cord (56.8%), laryngeal ventricle (53.5%), subglottis (47.1%), and paraglotic space (35.5%), respectively. Fifty-three percent of cases had stage IV cancer. The most common postoperative surgical sequela was hypothyroidism (77.8%). The overall 5-year survivals for laryngeal cancer and hypopharyngeal cancer were 55% and 9%, respectively. The 5-year survival for node-negative cases was 61.8% versus 17% for node-positive cases (p< 0.001). AJCC stage of laryngeal cancer and hypopharyngeal cancer was a significant predictor of 5-year survival (p< 0.001 and p = 0.004, respectively). Conclusions: The advanced AJCC stage, advanced T stage, advanced N stage, extracapsular tumor spread, and tumor invasion of false vocal cord, epiglottis, preepiglottic space, paraglottic space, thyroid cartilage, cricothyroid membrane were found to significantly augment the decrease of 5-year survival in laryngeal cancer. Only advanced AJCC stage was significantly associated with 5-year survival rate in hypopharyngeal cancer.
Impact of voice on emotional judgment of faces: An event‐related fMRI study

Emotional information can be conveyed by various means of communication, such as propositional content, speech intonation, facial expression, and gestures. Prior studies have demonstrated that inputs from one modality can alter perception in another modality. To evaluate the impact of emotional intonation on ratings of emotional faces, a behavioral study first was carried out. Second, functional magnetic resonance (fMRI) was used to identify brain regions that mediate crossmodal effects of emotional prosody on judgments of facial expressions. In the behavioral study, subjects rated fearful and neutral facial expressions as being more fearful when accompanied by a fearful voice as compared to the same facial expressions without concomitant auditory stimulus, whereas no such influence on rating of faces was found for happy voices. In the fMRI experiment, this shift in rating of facial expressions in presence of a fearfully spoken sentence was correlated with the hemodynamic response in the left amygdala extending into the periamygdaloid cortex, which suggests that crossmodal effects on cognitive judgments of emotional information are mediated via these neuronal structures. Furthermore, significantly stronger activations were found in the mid‐portion of the right fusiform gyrus during judgment of facial expressions in presence of fearful as compared to happy intonations, indicating that enhanced processing of faces within this region can be induced by the presence of threat‐related information perceived via the auditory modality. Presumably, these increased extrastriate activations correspond to enhanced alertness, whereas responses within the left amygdala modulate cognitive evaluation of emotional facial expressions. Hum Brain Mapp, 2006. © 2006 Wiley‐Liss, Inc.
Near-reshoring your supplies from China: a good deal for financial motives too

Purpose Reshoring, whether concerning back-reshoring or near-reshoring, is a quite recent phenomenon. Despite the economic and political interest of this topic, research questioning determinants and results of reshoring remain rare. The purpose of this paper is to help people to better understand reasons for reshoring. Design/methodology/approach To better understand reasons for near-reshoring, the authors conducted a study among 215 French firms in spring 2016, including 197 of them sourcing manufactured goods from China. Findings Near-reshoring is a recent but growing phenomenon: almost half of the companies sourcing in China chose over the past few years to near-reshore the supply of certain products initially purchased in China, and 10 per cent plan to do so soon. The authors determine main motives for near-reshoring and show that companies having reshored are very satisfied in terms of product quality, responsiveness between order and delivery, responsiveness between design and production, and in terms of total cost of ownership too. Originality/value Despite the economic and political interest of the topic of reshoring, research questioning determinants and results of reshoring remains rare.
Dissociation between cytokine mRNA expression and protein production in shigellosis

In our study, infection with Shigella dysenteriae type 1 (n = 16) or Shigella flexneri in adults (n = 5) was associated with a gradual accumulation of mRNA for interleukin (IL)‐1β, tumor necrosis factor (TNF)‐α, IL‐6, transforming growth factor‐β, IL‐10, IL‐4, TNF‐β, interferon (IFN)‐γ and perforin in the rectal biopsy samples during the convalescent stage of the disease demonstrated by in situ hybridization. In contrast, immunohistochemical staining in rectal tissues of cytokine protein‐producing cells at the single‐cell level exhibited a steady‐state expression during 2–36 days after the onset of the disease. The frequency of cytokine mRNA‐expressing cells varied in the range of 3–100‐fold higher than that of the corresponding protein‐synthesizing cells. The accumulation of cytokine mRNA in vivo during shigellosis represented a long‐lasting phenomenon throughout the disease course, and may be linked to its immunopathogenesis. The results also indicate that assessment of both protein and mRNA in vivo may provide complementary information. Stimulation in vitro of peripheral blood mononuclear cells from normal healthy donors with Shigella‐derived lipopoly‐saccharide or shiga toxin was carried out to elucidate the role of Shigella antigens in the regulation of translation of cytokine‐specific mRNA. The incidence of cytokine (IFN‐γ, IL‐6 and TNF‐α) mRNA‐ and cytokine protein‐expressing cells was very similar and congruent after both these Shigella‐derived stimuli. We could, thus, not find evidence for shiga toxin‐induced down‐regulation of cytokine mRNA translation as the explanation for the observed discrepancy between cytokine mRNA and protein levels in the tissue biopsies.
Collaboration and opportunism as a duality within social capital: a regional ethnic Chinese case study

Abstract Ethnic networks constitute a form of social capital and are central to the success of many ethnic Chinese entrepreneurs in Southeast Asia. The paper elucidates how such ethnic networks come to be formed and how they may create value through entrepreneurship. The findings suggest that ethnic networks can be an enabler of business cooperation but have problems stemming from an essentially dual nature that balances the benefits of such cooperation against tensions from self-interest, opportunism and covert dealings. These rarely described opportunistic characteristics are derived from the distinct historical background of ethnic Chinese business in Southeast Asia. The paper advances the existing concept of ethnic Chinese business networking by showing empirically, the workings of a case of the normally intricate phenomena. Three propositions for theory are also developed that highlight implications of the opportunism, and the rules of the game in which human capital is being used.
Do Knowledge Spillovers promote the coagglomeration between national and multinational firms

This study suggests a model for the agglomerative behaviour of MNEs with local competitors. Relying on foreign MNEs’ spatial distribution across 686 Italian Local Labor Systems, we find that MNEs’ locational behaviour is influenced by (i) informational externalities, giving rise to locational cascades and imitation of other foreign MNEs, and (ii) potential knowledge spillovers, which might act both as a centrifugal and a centripetal force, depending on the nature of local counterparts. Specifically, foreign MNEs tend not to agglomerate with local domestic companies as they perceive potential knowledge inflows to be lower than potential leakages, unless local companies enjoy some comparative advantages. Conversely, foreign MNEs’ are willing to agglomerate with other foreign MNEs, as they bet on a positive balance between knowledge inflows and outflows.
Macular zeaxanthins and lutein – a review of dietary sources and bioavailability and some relationships with macular pigment optical density and age-related macular disease

The retina is unique in the human body in containing three xanthophyll carotenoids; 3R,3′R-zeaxanthin, meso-zeaxanthin (MZ) and lutein. Humans consume 1 to 3 mg lutein per d and the lutein:zeaxanthin ratio in the diet is about 5:1.Xanthophyll pigments occur widely in vegetables and fruits but MZ is found in only a few foods such as the shrimp carapace and fish skin. In spite of the amounts of the different xanthophylls in the diet, zeaxanthin and MZ occur in approximately equal amounts in the eye, and their combined concentration can exceed that of lutein. In the present review the bioavailablity of zeaxanthin and lutein is assessed using the plasma xanthophyll response to dietary intervention. A number of studies have used single and mixed sources of the pure xanthophylls to achieve steady-state plasma responses. Mostly these have been with lutein and zeaxanthin but two using MZ are also described. Responses following the intervention with the pure xanthophylls are compared with those following food intervention. Vegetables are the richest source of dietary lutein and several vegetable-feeding studies are discussed. Intervention studies with eggs, which are a good source of zeaxanthin, suggest that the xanthophyll carotenoids in egg yolk may be more bioavailable than those in other foods and are described separately. MZ has been a component of a xanthophyll supplement added to chicken feed in Mexico in the last 10 years. Egg consumption in Mexico is approximately one egg/person per d and the potential contribution of this food source of MZ to Mexican dietary intakes is described. Very limited information from human feeding studies of MZ-containing supplements suggests that MZ is less well absorbed than zeaxanthin. However, MZ is unusual in the diet and not reported in the plasma. Thus plasma responses may not reflect true absorption if it takes MZ longer to equilibrate with body tissues than the other xanthophylls and competition with zeaxanthin may lower the relative concentrations of MZ in plasma. Lastly, the effects of long-term feeding with both pure and food sources of the xanthophyll pigments on macular pigment optical density is compared and the importance of previous dietary intake on the effects of intervention is discussed.
Prophylactic versus on‐demand treatment strategies for severe haemophilia: a comparison of costs and long‐term outcome

Summary. A multicentre study was performed to compare clotting factor use and outcome between on‐demand and prophylactic treatment strategies for patients with severe haemophilia. Data on treatment and outcome of 49 Dutch patients with severe haemophilia, born 1970–80, primarily treated with prophylaxis, were compared with those of 106 French patients, who were primarily treated on demand. Dutch patients received intermediate dose prophylaxis, for a median duration of 12.7 years. Patients primarily treated with prophylaxis had fewer joint bleeds per year (median 2.8 vs. 11.5), a higher proportion of patients without joint bleeds (29% vs. 9%), lower clinical scores (median 2.0 vs. 8.0), and less arthropathy as measured by the Pettersson score (median 7 points vs. 16 points). Mean annual clotting factor use was equal at 1488 ± 783 IU kg−1 year−1 (mean ± standard deviation) for patients primarily treated with prophylaxis and 1612 ± 1442 IU kg−1 year−1 for patients primarily treated on demand. These findings suggest that, compared with a primarily on‐demand treatment strategy, a primarily prophylactic treatment strategy leads to better outcome at equal treatment costs in young adults with severe haemophilia.
Australias ageing society.

The ageing of the Australian population is a subject which generates much popular and specialist discussion. This paper argues that productivity growth and income distribution are keys to responding to the ageing population through generating higher and more equitably shared standards of living for all Australians. The paper provides an overview of demographic trends the impact of migration the implications for social expenditures of our ageing population the impact of retirement income reform and issues relating to home community and institutional care of the aged. (EXCERPT)
Monitoring Vegetation Moisture Using Passive Microwave and Optical Indices in the Dry Chaco Forest, Argentina

Information about daily variations of vegetation moisture is of widespread interest to monitor vegetation stress and as a proxy to evapotranspiration. In this context, we evaluated optical and passive microwave remote sensing indices for estimating vegetation moisture content in the Dry Chaco Forest, Argentina. The three optical indices analyzed were the Normalized Difference Vegetation Index (NDVI), the Normalized Difference Water Index (NDWI) and the Normalized Difference Infrared Index (NDII) and, for the microwave region the Frequency Index (FI). All these indices are mainly sensitive to leaf area index (LAI), but NDWI and NDII, and FI are also sensitive to leaf water content (LWC) and Canopy Water Content (CWC) respectively. Using optical and microwave radiative transfer models for the vegetation canopy, we estimated the range of values of LAI, LWC and CWC that can explain both NDWI/NDII and FI observations. Using a combination of simulations and microwave and optical observations, we proposed a two step approach to estimate leaf and canopy moisture content from NDWI, NDII and FI. We found that the short variation of LWC estimated from NDWI and NDII present a dynamic range of values which is difficult to explain from the biophysical point of view, and it is partially related to atmosphere contamination and canopy radiative transfer model limitations. Furthermore, the observed FI short-term variations (~ 8 days) cannot be explained unless significant CWC variations are assumed. The CWC values estimated from FI present a short-term variations possibly related to vegetation hydric stress.
Prostaglandins and leukotriene B4 are potent inhibitors of 11beta-hydroxysteroid dehydrogenase type 2 activity in human choriocarcinoma JEG-3 cells.

The 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) is responsible for the inactivation of glucocorticoids. This is the predominant isozyme in the human placenta, where it is proposed to protect the fetus from high levels of maternal cortisol. In the present study, we examined the effects of eicosanoids on the activity of 11beta-HSD2 in human choriocarcinoma JEG-3 cells, a well-established model for placental trophoblasts. Treatment of JEG-3 cells for 24 h with either prostaglandin (PG) E2 or F2alpha attenuated 11beta-HSD2 activity ( approximately 40%). Paradoxically, indomethacin, an inhibitor of cyclooxygenases, inhibited (approximately 40%) rather than stimulated the activity of this enzyme. This indicated that the arachidonic acid metabolism may be diverted to other pathway(s), the products of which may inhibit 11beta-HSD2 activity. To determine whether the lipoxygenase pathways were involved, the cells were treated with nordihydroguaretic acid (NDGA), a blocker of all three (5-, 12-, and 15-) lipoxygenases. NDGA caused a 3-fold increase in 11beta-HSD2 activity. To further delineate which specific lipoxygenase pathway was involved, the cells were incubated with zileuton, a selective inhibitor of 5-lipoxygenase. This resulted in a similar increase in 11beta-HSD2 activity, suggesting that the products of this pathway (e.g., leukotrienes) may be involved. Given that leukotriene B4 (LTB4) is the most biologically active product of the 5-lipoxygenase pathway, we treated the cells with LTB4, which inhibited 11beta-HSD2 activity in a time- and dose-dependent manner with a maximal effect (60% reduction) at 10 nM for 9 h. Semiquantitative reverse transcription-polymerase chain reaction analysis revealed that 11beta-HSD2 mRNA levels were not altered by the addition of LTB4, PGE2, or PGF2alpha, indicating an effect at the posttranscriptional level. In conclusion, these results demonstrate that prostaglandins and LTB4 are potent inhibitors of 11beta-HSD2 activity in JEG-3 cells, suggesting that placental 11beta-HSD2 activity is modulated by these locally produced eicosanoids. This is the first time that the products of arachidonic acid metabolism have been found to regulate the activity of 11beta-HSD2.