Miracle-dz/UniFAR-FTUs huggingface dataset:
Smartphone-Based Health Technologies for Dementia Care: Opportunities, Challenges, and Current Practices

Most of the 5.4 million people affected by Alzheimer’s disease and other forms of dementia (AD) are noninstitutionalized, receiving care by unpaid family caregivers and medically managed by a primary care provider (PCP). Health Information Technology has been recognized for its potential in improving efficiency and quality of AD care and support for AD caregivers. Simultaneously, smartphone technologies have become an increasingly common way to deliver physical and behavioral health care. However, little is known about how smartphone technologies have been used to support AD caregiving and care. This article highlights the current need for smartphone-based interventions for AD and systematically identified and appraised current smartphone apps targeting and available for AD caregivers. Findings indicate that individual available apps have limited functions (compared with the complex needs of caregivers) and little has been done to extend AD caregiving apps to Hispanic populations. Implications for research, practice, and policy are discussed.
Assessment of hemostatic changes after initiation of continuous venovenous hemodialysis.

BACKGROUND Continuous renal replacement therapy (CRRT) is a standard therapy in critically ill patients suffering from acute kidney injury (AKI). Extracorporeal circulation and exposure to foreign surfaces during CRRT may induce disturbances in hemostasis, particularly in platelet function. The present study described the hemostatic changes associated with CRRT and aimed to identify the independent predictors of premature clotting of the circuit. METHODS In a prospective cohort mono-center study, patients were assessed for eligibility if they were i) diagnosed with AKI and ii) assigned to receive CRRT for the first time. Patients were included in the study if their platelet count was greater than 100/nL prior to inclusion in the study. After initiation of CRRT, aggregometric [Multiplate, Roche, Grenzach, Germany: Arachidonic acid (ASPItest)-, ADP (ADPtest)- and Thrombin (TRAPtest)-induced platelet aggregation] and viscoelastic (ROTEM; TEM International, Munich, Germany) analyses were performed immediately before (Baseline, T1) and 6 hours (T2), 12 hours (T3), 24 hours (T4), and 48 hours (T5) after initiation of CRRT. Conventional laboratory coagulation analyses were routinely performed twice a day. Arachidonic acid- and ADP-induced platelet aggregations were defined as primary endpoints. RESULTS A total of 127 patients were screened for eligibility, and 50 patients were enrolled in this study. Aggregometric analyses showed that arachidonic acid-induced platelet aggregation was significantly reduced at T2 [532 (210/1105) median (25th/75th percentile) AU*min] compared to the Baseline at T1 [780 (297/1156), p = 0.007] and remained unchanged from T2 onward. Platelet aggregation in the ADPtest and TRAPtest remained unchanged during the study period. Viscoelastic and conventional coagulation analyses indicated a progredient increase of clot firmness. In total, 76 filter sets (an average of 1.5 per patient) were used, and 26 filter sets occluded prematurely after an average treatment time of 17 ± 12 hours. No predictors for premature clotting of the circuit were identified. CONCLUSIONS The results of the present study indicate that CRRT may lead to impaired primary hemostasis as shown by a decrease in ex vivo arachidonic acid-induced platelet aggregation. Moreover, viscoelastic measure indicate a fibrinogen-associated trend of increasing clot firmness during the study period. Further studies are needed to analyze whether these findings are of hemostatic relevance.
Cytogenetic and morphologic subgroups of myelodysplastic syndromes in relation to occupational and hobby exposures.

OBJECTIVES This study investigated the association between occupational and hobby exposure and the risk of myelodysplastic syndromes (MDS) while focusing on differential patterns of clonal chromosome aberrations and morphologic subgroups. METHODS A case-referent study was conducted with 330 MDS patients investigated cytogenetically in 1976-1993 (cases) and matched referents. Telephone interviews with either the person or a next-of-kin were used. The participation rate of the cases and referents was 85% and 60%, respectively. Information was obtained from the next-of-kin more often for the cases (88%) than for the referents (26%). Occupational hygienists assessed the exposure using interview data on worktasks and hobbies. Associations with disease risk were evaluated for 10 exposures with a logistic regression analysis. RESULTS The investigated exposures were generally not associated with cytogenetically abnormal MDS. Effect estimates for specific cytogenetic or morphologic subgroups were generally imprecise. Occupational exposure to extremely low-frequency magnetic fields (EMF) was associated with MDS with a normal karyotype [odds ratio (OR) 2.0, 95% confidence interval (95% CI) 1.0-4.0]. The exposure-response association was consistent for intensity but inconclusive for duration. A decreased risk was observed for MDS, irrespective of karyotypic pattern, among farmers and farmhands (OR 0.53, 95% CI 0.35-0.81). CONCLUSIONS Cytogenetically abnormal MDS was generally not associated with occupational or hobby exposure to known or suspected genotoxic agents. However, exposure prevalences and intensities were low for several agents. An association was suggested between occupational exposure to EMF and MDS with a normal karyotype. Biases due to differential information quality and selective participation cannot be ruled out.
Conflict Monitoring in Cognition-Emotion Competition.

Emotion regulation allows behavior to be guided in favor of long-term goals when these are at odds with the influence of a competing, emotional response. In this chapter, we propose that conflict may serve as one measure used by the brain to determine when emotion regulation is necessary, paralleling the similar use of conflict signals to signal the need to regulate interference arising from non-emotional processes. Conflict has been well studied in contexts where cognitive control is required to avoid erroneous or prepotent responses in cognitive tasks. Brain responses in the anterior cingulate cortex correlate with the level of conflict and predict subsequent increases in prefrontal cortex activity and exertion of control. Drawing upon findings from tasks in a variety of domains, including economic decision-making, social exchange, and moral judgments, we show that the anterior cingulate cortex is also activated under conditions in which there is competition between emotional and cognitive processes. Based on the hypothesis that the anterior cingulate cortex engages control mechanisms that regulate emotional processes as it does the regulation of cognitive processes, we speculate about how decision-making proceeds in cases involving cognition-emotion competition.
Organic Fertilizers for Greenhouse Tomatoes: Productivity and Substrate Microbiology

Organic fertilizer regimens consisting of combinations of composts (yard waste, swine manure, or spent mushroom substrate) and liquid fertilizers (fish- or plant-based) were evaluated against conventional hydroponic fertilizers in two experiments with greenhouse tomatoes grown in peat-based substrate. Crop yield and fruit quality were evaluated and several assays of substrate microbial activity and community profiles (fluorescein diacetate analysis and EcoLog, values, nematode counts) were conducted. Crops grown in 20% to 40% compost (yard waste or yard waste plus swine manure) plus a continuously applied liquid source of organic potassium (K), calcium (Ca), magnesium (Mg), and sulphate (SO4) could not be sustained more than 1 month before nutrient deficiencies became visible. Supplementation with a nitrogen (N)- and phosphorus (P)- containing plant-based liquid fertilizer at the point when plant deficiencies became apparentsubsequentlyproducedyields '80%thatofthehydroponiccontrol.Inasecond experiment, the proportion of mushroom or yard waste compost was increased to 50% of themix,andliquiddeliveryofK,Ca,MgandSO4pluseitherplant-basedorfish-basedN- and P-containing liquid feeds was started at the date of transplanting. In this case, organic yields equal to that of the hydroponic control (8.5 kg/plant) were observed in some treatments. The most productive organic treatment was the mushroom compost supplemented with a low concentration of the plant-based liquid fertilizer. In general, organic tomatoes had a lower postharvest decay index (better shelf life) than did the hydroponic controls, possibly as an indirect consequence of overall reduced yield in those treatments. High concentrations of both organic liquid feeds resulted in lower yields as a result of treatment-induced fusarium crown and root rot. In contrast to some previous studies, those treatments showing fusarium crown and root rot also had the highest gross microbial activity. Measures of gross microbial activity and numbers of microbivorous nematodes were higher (average of 37% and 6.7 times, respectively) in compost/organic feed treatments than in the hydroponic control. Community physiological profiles of the bacterial populations, on the other hand, did not differ between organic and hydroponic treatments. Nematode populations were significantly correlated with gross microbial activity in the organic treatments.
Assessment of the Knowledge , Attitude and Practices of Rabies in Arada Sub City Addis Ababa , Ethiopia

This study was conducted from November, 2015 to April, 2016 in Arada sub-city which is one of the ten sub-cities of Addis Ababa, Ethiopia. The sub-city covers area of 949.85 ha and has a population size of about 225,999 which makes it one of the densely populated sub-cities in Addis Ababa. The study is done in a cross-sectional study design and multistage sampling procedures were employed to select households for this study. Arada sub city were randomly selected from Addis Ababa. Three Administrative woreda were selected using lottery method from the list of Arada sub city, followed by selection of households from each woreda using systematic random sampling method. The data were collected from 384 households through face to face interview using pretested and structured questionnaires. SPSS Windows version 20.0 was used for data analysis. Descriptive statics techniques and Pearson’s chi squares analysis were used to manage the data and the association between outcome (KAP) and explanatory variables. Of the 384 respondents interviewed, 197 (51.3%) of them were males and 187 (48.7%) females and 154 (40.1%) were between 15-24 years old. The majority of the respondents 177 (46.1%) were Orthodox. Almost all of the respondents indicated that they had previously heard about rabies. The majority of the study participants 258 (67.2%) had good level of KAP. There was strong association between KAP scores and age (x = 12.860, p < 0.05); and occupation (x =16.232, p < 0.05). Generally, 2 2 these findings indicate that a good level of awareness was shown with regard to rabies among the residents of Arada sub city Addis Ababa. Additionally, inaccessibility to appropriate services was also considered as a major reason for the poor level of community participation in rabies but it need for educational outreach to raise accurate knowledge on mode of transmission, symptoms and appropriate prevention and treatment measures.
EVALUATION OF ANTIMICROBIAL ACTIVITY OF SOME PLANT EXTRACTS AGAINST MULTIDRUG RESISTANT-METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS ( MDR-MRSA ) *

Four different varieties of seeds were obtained from authentic seed suppliers on the basis of ethnopharmacological information. Ethanol, methanol, acetone, chloroform and petroleum ether seed extracts were assessed for antibacterial activity against wound isolates of Multi Drug Resistant Methicillin Resistant Staphylococcus aureus (MDR-MRSA). Ethanol, methanol and acetone extracts of Moringa oleifera, Elettaria cardamomum and Tamarindus indica seeds showed more effective anti MRSA activity than Artocarpus heterophyllus. In addition, Moringa oleifera seed extracts may have the potential to restore the effectiveness of ȕ-lactam antibiotics against MRSA.
Extended family relationships, social support, and mental health in a southern black community.

Les perspectives contemporaines sur la famille noire suggerent que la famille etendue est une source essentielle de support social a l'interieur de la communaute noire. Les influences sur l'etat depressif d'un certain nombre de relations sociales sont examinees; on passe en revue: les dimensions de la parente etendue et la perception comparee du soutien venant de la parente et venant des non-parents. Les symptomes depressifs ont paru en raison inverse du soutien par la parente. L'effet tampon du soutien de la parente etendue sur les evenements existentiels n'est evident que chez les hommes. Il n'y a pas d'effet tampon du support social sur les facteurs chroniques de stress.
Study of Ecological and Epidemiological Factors of Dengue Viral Fever in Districts of West Bengal in a Tertiary Care Hospital

Dengue fever is one of the major tropical diseases caused by dengue virus especially in tropical and subtropical countries, mainly involving urban and semi-urban areas. A hospital based observational study was carried out in our tertiary care centre from 01.11. 2018 to 31.12. 2018 to determine ecological and epidemiological factors of dengue viral fever in districts of West Bengal. A total no of 692 serum samples were tested for anti-dengue IgM antibodies and NS1 antigen with overall prevalence of 6.79%. The rate of seropositivity was highest i.e. 46.8% in 15-30 years age group and the study found statistically significant association between rate of seropositivity and age group (p value <0.05). Though there was male preponderance but it was not found to be statistically significant. Maximum Dengue cases were observed in Kolkata districts (38.12%) followed by Howrah (17%) districts. Majority of cases occurred in the month of November. The dengue fever was affecting both the genders almost equitably and mostly the younger age group from urbanas well as rural areas. Thereby understanding of local epidemiology, risk factors and disease burden in dengue is essential to initiate preventive measures. -------------------------------------------------------------------------------------------------------------------------------------Date of Submission: 07-04-2019 Date of acceptance: 22-04-2019 -------------------------------------------------------------------------------------------------------------------------------------
Her-2/neu overexpression and amplification in uterine papillary serous carcinoma.

PURPOSE Uterine papillary serous carcinoma (UPSC) is an aggressive subtype of endometrial cancer characterized by early metastasis, resistance to therapy, and a high mortality rate. Little is known about the biology of these tumors. Smaller studies suggest that Her-2/neu may be involved in the tumorigenesis of this disease. The purpose of this study was to evaluate the protein expression and gene amplification of Her-2/neu in UPSC and to determine its prognostic value. PATIENTS AND METHODS Tumor tissue from 68 patients with UPSC treated at The University of Texas M.D. Anderson Cancer Center from 1989 to 2002 was available. Her-2/neu expression was evaluated by immunohistochemistry (IHC). Overexpression was defined as complete membrane staining in greater than 10% of the cells. In tumors with overexpression of Her-2/neu by IHC, fluorescence in situ hybridization (FISH) was performed to assess gene amplification. Clinical and pathologic information was obtained from medical records. RESULTS Twelve (18%) of 68 tumors demonstrated Her-2/neu overexpression. Of these, only two showed gene amplification. When evaluating all 68 patients, Her-2/neu overexpression was associated with a poorer overall survival (OS; P = .008). In our multivariate Cox proportional hazards models, Her-2/neu IHC overexpression, lymph node status, and stage were each associated with OS (P < or = .05). CONCLUSION Positive IHC overexpression of Her-2/neu was seen in 18% of UPSCs but was rarely correlated with Her-2/neu gene amplification. Overexpression of Her-2/neu was associated with a worse overall prognosis. The use of trastuzumab (Herceptin; Genentech, South San Francisco, CA) in women with UPSC should be further evaluated in a clinical trial setting.
Longitudinal analysis of a pediatric rheumatology clinic population.

OBJECTIVE To analyze a prospectively maintained pediatric rheumatology clinic disease registry. METHODS A total of 3269 consecutive referrals to the Pediatric Rheumatology Clinic, University of Saskatchewan, during the period 1981-2004 were analyzed. RESULTS Among 3269 patients, a diagnosis was established in 2098 (64.2%). Within this group, 72 subjects (3.4%) were determined to be healthy. Of the remaining 2026 diagnosed patients (62.0% of the total population), 1032 (50.9%) had a rheumatic disease and 994 (49.1%) a nonrheumatic disease. A diagnosis was not established in 1171 patients (35.8%). Among the 1032 patients with a rheumatic disease, 326 (31.6%) had juvenile rheumatoid arthritis (JRA), 360 (34.9%) a spondyloarthropathy (SpA), and 225 (21.8%) a collagen vascular/connective tissue rheumatic disease. The remaining 121 patients with a rheumatic disease (11.7%) had a variety of other conditions. Of the 994 nonrheumatic disease patients, 37 (3.7%) with ocular inflammatory conditions had been referred to exclude an associated rheumatic disease. The remaining group of 957 patients comprised 345 (36.1%) with an orthopedic, mechanical or traumatic condition, 231 (24.1%) had an infection, 45 (4.7%) a hematologic or neoplastic disease, and 336 (35.1%) a variety of other conditions. Current clinic point prevalences for JRA, SpA, and collagen vascular diseases are 35.0, 16.9 and 17.7/100,000, respectively. The mean annual clinic referral incidences of JRA, SpA, and collagen vascular/connective tissue diseases were, respectively, 4.7, 5.2, and 1.7/100,000 children. CONCLUSION Disease registries help establish the frequencies and spectrum of childhood rheumatic diseases and the role of pediatric rheumatology programs in evaluating and caring for children with a wide variety of conditions. Longitudinal disease registries aid in characterizing clinical, epidemiologic, and demographic features of childhood rheumatic diseases.
The effects of competing precursors and pre-oxidation on N-Nitrosodimethylamine formation from ranitidine upon chloramination

N-nitrosodimethylamine (NDMA) is a potent carcinogen and frequently detected nitrosamine from water chloramination. This study investigated the effects of pre-oxidation on the reduction of NDMA formation potential (FP) from ranitidine (RNT) upon subsequent chloramination. Reactive chlorine species (RCS) were generated by employing a coated titanium anode with IrO2 -Ta2O5 and a titanium plate as a cathode material. The TiO2 photocatalyst was immobilized by electrospraying TiO2 dispersion on stainless-steel mesh. In addition, the effects of competing NDMA precursors on the NDMA FP of RNT was examined. Reduced NDMA FP values of RNT in the presence of co-existing compounds might be ascribed to competing reactions and NH2Cl demand. In the presence of N,N-diethyhydroxylamine, complete inhibition of NDMA FP resulted from the depletion of dissolved oxygen. Pre-chlorination was found to effectively mitigate NDMA FP, depending on the applied [RCS]0, duration, and pH. The NDMA FP of RNT decreased approximately 95–99.3% with an increase in the pre-oxidation time and applied [RCS]0 dose. The optimal pH with a contact time of 30 min and [RCS]0 of 0.15 mM to achieve an insignificant level of NDMA FP ranged from 6.5 to 7.0. However, using ultraviolet (UV) photolysis alone, the NDMA FP of RNT was reduced by ca. 50%, while 30 min of irradiation with TiO2 significantly reduced the NDMA FP up to 84%. These results demonstrated that both UV/TiO2 and RCS were effective in minimizing the NDMA FP.
ROLE OF PSYCHOLOGICAL CAPITAL ( PSYCAP ) IN LEADERSHIP EFFECTIVENESS

Psychological Capital or PsyCap has gained prominen ce as an important construct in leadership research. Comprising four factors (selfefficacy, hope, optimism, and resiliency), PsyCap is considered to be a vital factor for both leadership development and influence. The current study reports the results of a questionnair e survey that was conducted in the construction industry of Singapore. The survey expl ored the correlations of PsyCap with various form of leadership and leadership outcomes. The results show that PsyCap significantly correlates with transformational lead rship and leadership effectiveness. The discussion in the paper also considers the implicat ions of PsyCap for leadership development and effectiveness.
Descemet Stripping Automated Endothelial Keratoplasty Combined with Phacoemulsification in Chandler Syndrome

Purpose TO report a case of Descemet stripping automated endothelial keratoplasty (DSAEK) in combination with phacoemulsification and implantation of intraocular lens (IOL) (triple procedure) in a patient with Chandler syndrome. Methods A patient with visually significant corneal edema due to Chandler syndrome and cataract underwent DSAEK combined with phacoemulsification and IOL implantation (DSAEK triple procedure). Results One year postsurgery the patient's uncorrected distance visual acuity improved from counting fingers to 20/63, and the corrected distance visual acuity to 20/32. The cornea was clear with absence of corneal edema. Conclusions In the presented case, DSAEK triple procedure was an effective treatment for corneal edema secondary to Chandler syndrome in the presence of cataract.
Electrostatic switching biosensor - a novel label-free DNA detection using an electrode charging technique

This paper reports a novel electrical detection of label-free DNA by use of a MEMS electrostatic micro-switch. The electrostatic micro-switch detects the immobilization of probe oligonucleotides and their hybridization with target oligonucleotides using pull-in voltage shift in the micro-switch originated from negative charges of the oligonucleotides. A numerical simulation is analyzed to support this concept. The proposed biomolecule detection method using an electrostatic micro-switch represents a protocol for a new candidate of microactuator-type sensor.