Miracle-dz/UniFAR-FTUs huggingface dataset:
Equitable allocation of HLA-compatible kidneys for local pools and for minorities.

BACKGROUND The methods used to allocate cadaveric kidneys in the United States have been criticized as being unfair to minorities because of an over-emphasis on HLA matching. We evaluated a new HLA-matching method that might alleviate this problem. METHODS We used data from the United Network for Organ Sharing (UNOS) Kidney Transplant Registry to evaluate and project the outcome of cadaveric kidney transplantation. An HLA-matching method based on compatibility at 10 key amino acid residues of HLA-A and B molecules and a limited number of HLA-DR types was evaluated with use of the HLA types of the patients currently on the national waiting list and waiting lists in Los Angeles and Birmingham, Alabama. RESULTS With national kidney sharing, the projected 10-year rate of graft survival for transplants in which there were no HLA-A, B, or DR mismatches was 66 percent, as compared with 39 percent for transplants with more than two HLA-A, B, or DR mismatches. With local sharing, 43 percent of patients could be fully matched, and they had a projected 10-year graft-survival rate of 50 percent. When one HLA-DR mismatch was allowed, the projected 10-year graft survival was 46 percent, and 67 percent of patients waiting locally could receive such grafts. Even in Alabama, where 68 percent of the patients on the waiting list are black, 48 percent of waiting patients could obtain a matched kidney. CONCLUSIONS Inserting two new HLA-matching categories into the UNOS point system for cadaveric kidney allocation would increase the number of patients for whom matches could be found in local pools.
Prevalence of headache in an elderly population: attack frequency, disability, and use of medication

OBJECTIVES To assess the 1 year prevalence of tension-type headache (TTH), migraine headache (MH), and chronic daily headache (CDH), as well as of headache in general in a rural elderly population. METHODS A door to door two phase survey was carried out on all elderly (⩾65 years) residents in three villages in central Italy. Participants completed a standardised headache questionnaire and underwent a clinical evaluation by a neurologist. Headache diagnosis was made according to the classification of the International Headache Society, with minor modifications for the classification of patients with MH with⩾15 attacks/month. RESULTS Eight hundred and thirty three (72.6%) of the 1147 eligible persons completed the study protocol. One year prevalence rates were respectively 44.5% for TTH, 11.0% for MH, 2.2% for symptomatic headaches, and 0.7% for the remaining types of headache. The prevalence of headache in general was 51.0% because 62 residents had both TTH and MH attacks. Prevalence rates of patients with headache were higher in women than men (62.1% and 36.6% respectively) and decreased steadily with age for the 65–74, 75–84, and 85–96 age groups (56.7%, 45.2% and 26.1% respectively). Prevalence rates were 20.4% for patients with moderate to severe attacks, 18.0% for those with ⩾1 attacks a month, and 4.4% for those with CDH. Of the 425 with headache 52 (12.2%) had not taken any drugs for their attacks in the previous year, 195 (45.9%) had taken them regularly, and 178 (41.9%) had taken them only when the headache pain interfered with activities that could not be postponed. Medication overuse was reported by 37.8% of patients with CDH with higher proportions for transformed migraine than for patients with chronic TTH (69.2% and 23.8% respectively, p=0.009) CONCLUSIONS A consistent proportion of elderly people have primary headaches and consultation with a specialist is particularly recommended for patients with moderate or severe attacks, or with CDH.
[Salivary flow and psychoactive drug consumption in elderly people].

OBJECTIVE To analyze the association between low saliva flow rates and the use of psychoactive drugs among the elderly. METHODS A cross-sectional study was carried out with 267 elderly people from 60 to 74 years of age who lived in a borough of the city of Londrina, Paraná State, Brazil. Individuals with high functional dependence or restricted to bed were excluded. Saliva flow rate was the dependent variable with values under the first tercile being considered as low flow rates (less than 0.44 ml/min). The continuous use of psychoactive drugs (antidepressant, antiepileptic, sedative, antipsychotic, hypnotic or sedative-hypnotic drugs) was the independent variable. Multivariate analysis was performed taking into account gender, age and smoking status. RESULTS The majority of the elderly were women (80.5%), with a mean age of 66.5 years. Use of psychoactive drugs was observed among 31 elderly (11.6%). Mean saliva flow rate was 0.76 ml/min, lower among users of psychoactive drugs (0.67 ml/min). In the multivariate analysis, use of psychoactive drugs was associated with low saliva flow rates (<0.44 ml/min), independent of gender, age or smoking. CONCLUSION Results show that there is an association between use of psychoactive drugs and low saliva flow rates in this group of independent and non-institutionalized elderly. These conclusions stress the need of a rational use of these drugs, particularly among the elderly.
Resistive wall impedance of beam pipes of general cross-section

A method of calculating the coupling impedance and the wake function of resistive beam pipes is given including the short-range behavior of the wake. The pipe is uniform longitudinally but the cross section is arbitrary. The beam is assumed to be ultra-relativistic. A simple computer code is written using the boundary element method. Some results for elliptic, rectangular and hyperbolic pipes are presented.
Real‐time quantitative polymerase chain reaction (qPCR) analysis with fluorescence resonance energy transfer (FRET) probes reveals differential expression of the four ERBB4 juxtamembrane region variants between medulloblastoma and pilocytic astrocytoma

Aims: We report a comparative study on the mRNA expression of ErbB receptor tyrosine kinases, and in particular ERBB4 transcript variants, in two common paediatric brain tumours: medulloblastoma (MB) and pilocytic astrocytoma (PA). Methods: While the conventional real‐time quantitative polymerase chain reaction was used to measure the expression of ERRBs and ErbB4‐processing protease genes, the LightCycler fluorescence resonance energy transfer probes were specifically designed to investigate all of the known ERBB4 juxtamembrane (JM) and cytoplasmic transcript variants. Results: The overall expression of ERBBs suggests that ErbB2/ErbB4 heterodimers and ErbB4 homodimers may be major functional units of the ErbBs in MB, while ErbB2/ErbB3 heterodimers may play a more prominent role in addition to ErbB4‐containing dimers in PA. Different expression patterns of ERBB4 JM transcripts in MB, PA and normal brain were observed. The JM‐d variant was only detected in MBs, while JM‐c was present in MB and PA but was not identified in normal brain. The expression of cleavable ERBB4 transcript variants was elevated in PAs and MBs compared with normal brain, while mRNA levels of ErbB4‐processing proteases were similar in both tumour types and normal brain. This suggests that proteolytic cleavage of ErbB4 may be more common in MB and PA, which leads to signalling events divergent from those in normal brain. Conclusion: Taken together, these results suggest that ErbB4 processing and function may be altered in brain tumours, such as MB and PA, via differential expression of JM transcript variants.
Recombination and photoluminescence mechanism in hydrogenated amorphous carbon.

The luminescence mechanism in a-C:H is described as a modification of the band tail luminescence in hydrogenated amorphous Si. The tail states of a-C:H are formed from clusters of ${\mathit{sp}}^{2}$ sites and luminescence occurs by recombination within each cluster. The paramagnetic defects are confirmed as the nonradiative recombination centers. The weaker temperature dependence of the luminescence efficiency of a-C:H than a-Si:H is attributed to its wider tails which inhibit carrier hopping. The luminescence efficiency is also quenched by narrow optical gaps, because carriers can tunnel to defects more easily in the ${\mathit{sp}}^{2}$-rich, narrow-gap a-C:H. Defect quenching is less strong, however, because of the shorter Bohr radius of localized states in a-C:H. \textcopyright{} 1996 The American Physical Society.
Folding and binding cascades: Dynamic landscapes and population shifts

Whereas previously we have successfully utilized the folding funnels concept to rationalize binding mechanisms (Ma B, Kumar S, Tsai CJ, Nussinov R, 1999, Protein Eng 12:713–720) and to describe binding (Tsai CJ, Kumar S, Ma B, Nussinov R, 1999, Protein Sci 8:1181–1190), here we further extend the concept of folding funnels, illustrating its utility in explaining enzyme pathways, multimolecular associations, and allostery. This extension is based on the recognition that funnels are not stationary; rather, they are dynamic, depending on the physical or binding conditions (Tsai CJ, Ma B, Nussinov R, 1999, Proc Natl Acad Sci USA 96:9970–9972). Different binding states change the surrounding environment of proteins. The changed environment is in turn expressed in shifted energy landscapes, with different shapes and distributions of populations of conformers. Hence, the function of a protein and its properties are not only decided by the static folded three‐dimensional structure; they are determined by the distribution of its conformational substates, and in particular, by the redistributions of the populations under different environments. That is, protein function derives from its dynamic energy landscape, caused by changes in its surroundings.
PENGARUH PENDAPATAN ASLI DAERAH (PAD), DANA ALOKASI UMUM DAN DANA ALOKASI KHUSUS TERHADAP PERTUMBUHAN EKONOMI DI KOTA TOMOHON

ABSTRAKPertumbuhan ekonomi merupakan salah satu indikator yang digunakan dalam menentukan keberhasilan pembangunan. Pertumbuhan ekonomi yang tinggi dapat membuat kesejahteraan masyarakat menjadi semakin baik. Pertumbuhan ekonomi dapat diartikan sebagai perkembangan kegiatan dalam perekonomian yang menyebabkan barang dan jasa yang diproduksi dalam masyarakat bertambah (Sukirno, 2010). Tujuan dari penelitian ini untuk menganalisis bagaimana pengaruh PAD, DAU dan DAK terhadap pertumbuhan ekonomi di Kota Tomohon. Desentralisi berarti penyerahan urusan pemerintah dari pemerintah daerah tingkat atas kepada daerah (kuncoro, 2006). Semakin tinggi PAD yang diperoleh suatu daerah maka akan semakin tinggi pertumbuhan ekonomi di daerah tersebut. Menurut Brata (2004) yang dikutip oleh Adi dan Harianto (2007) menyatakan bahwa terdapat dua komponen penerimaan daerah yang berpengaruh positif secara signifikan terhadap pertumbuhan ekonomi daerah yaitu PAD serta sumbangan dan bantuan. Teknik analisis yang digunakan adalah analisis regresi berganda. Hasil penelitian menunjukan bahwa pendapatan asli daerah berpengaruh positif akan tetapi tidak signifikan terhadap pertumbuhan ekonomi. dana alokasi umum berpengaruh positif signifikan terhadap pertumbuhan ekonomi. dana alokasi khusus berpengaruh positif signifikan terhadap pertumbuhan ekonomi. Kata Kunci: Pendapatan Asli Daerah (PAD), Dana Alokasi Umum (DAU), Dana Alokasi Khusus (DAK) dan Pertumbuhan Ekonomi ABSTRACTEconomic growth is one of the indicators used in determining the success of development. High economic growth can make people's welfare even better Economic growth can be defined as the development of activities in the economy that cause goods and services produced in the community increases (Sukirno, 2010). The purpose of this study is to analyze how the influence of PAD, DAU and DAK on economic growth in Tomohon City. Decentralization means the handover of government affairs from upper level regional governments to regions (kuncoro, 2006). The higher the PAD obtained by a region, the higher the economic growth in the region. According Brata (2004) cited by Adi and Harianto (2007) states that there are two components of local revenue that significantly positive effect on regional economic growth that is PAD and donations and assistance. The analysis technique used is multiple regression analysis. The result of research shows that the original revenue of the region has positive but not significant effect on the economic growth. general allocation funds have a significant positive effect on economic growth. special allocation funds have a significant positive effect on economic growth. Keywords: Pendapatan Asli Daerah (PAD), General Allocation Fund (DAU), Special Allocation Fund (DAK) and Economic Growth
Resistance of Pseudomonas aeruginosaIsolates to Hydrogel Contact Lens Disinfection Correlates with Cytotoxic Activity

ABSTRACT One of the most common pathogens in infection of hydrogel contact lens wearers is Pseudomonas aeruginosa, which can gain access to the eye via contamination of the lens, lens case, and lens care solutions. Only one strain per species is used in current regulatory testing for the marketing of chemical contact lens disinfectants. The aim of this study was to determine whether P. aeruginosa strains vary in their susceptibility to hydrogel contact lens disinfectants. A method for rapidly screening bacterial susceptibility to contact lens disinfectants was developed, based on measurement of the MIC. The susceptibility of 35 P. aeruginosa isolates to two chemical disinfectants was found to vary among strains. MICs ranged from 6.25 to 100% for both disinfectants at 37°C, and a number of strains were not inhibited by a 100% disinfectant concentration in the lens case environment at room temperature (22°C). Resistance to disinfection appeared to be an inherent rather than acquired trait, since some resistant strains had been isolated prior to the introduction of the disinfectants and some susceptible P. aeruginosa strains could not be made more resistant by repeated disinfectant exposure. A number of P. aeruginosa strains which were comparatively more resistant to short-term disinfectant exposure also demonstrated the ability to grow to levels above the initial inoculum in one chemical disinfectant after long-term (24 to 48 h) disinfectant exposure. Resistance was correlated with acute cytotoxic activity toward corneal epithelial cells and with exsA, which encodes a protein that regulates cytotoxicity via a complex type III secretion system. These results suggest that chemical disinfection solutions may select for contamination with cytotoxic strains. Further investigation of the mechanisms and factors responsible for resistance may also lead to strategies for reducing adverse responses to contact lens wear.
Recovering phosphorus from soil: a root solution?

Marc I. Stutter,*,† Charles A. Shand,† Timothy S. George,† Martin S. A. Blackwell,‡ Roland Bol,‡ Regina L. MacKay, Alan E. Richardson, Leo M. Condron, Benjamin L. Turner, and Philip M. Haygarth †The James Hutton Institute, Aberdeen, AB15 8QH, U.K. and Dundee, DD2 5DA, U.K. ‡Rothamstead Research North Wyke, Devon, EX20 2SB, U.K. College of Life Sciences, University of Dundee, Dundee, DD1 5EH, U.K. CSIRO Plant Industry, Black Mountain, Canberra, ACT 2601, Australia Faculty of Agriculture and Life Sciences, Lincoln University, Lincoln 7647, Canterbury, New Zealand Smithsonian Tropical Research Institute, Republic of Panama Lancaster Environment Centre, Lancaster University, LA1 4YQ, U.K.
Trabecular bone adaptation to loading in a rabbit model is not magnitude‐dependent

Although mechanical loading is known to influence trabecular bone adaptation, the role of specific loading parameters requires further investigation. Previous studies demonstrated that the number of loading cycles and loading duration modulate the adaptive response of trabecular bone in a rabbit model of applied loading. In the current study, we investigated the influence of load magnitude on the adaptive response of trabecular bone using the rabbit model. Cyclic compressive loads, producing peak pressures of either 0.5 or 1.0 MPa, were applied daily (5 days/week) at 1 Hz and 50 cycles/day for 4 weeks post‐operatively to the trabecular bone on the lateral side of the distal right femur, while the left side served as an nonloaded control. The adaptive response was characterized by microcomputed tomography and histomorphometry. Bone volume fraction, bone mineral content, tissue mineral density, and mineral apposition rate (MAR) increased in loaded limbs compared to the contralateral control limbs. No load magnitude dependent difference was observed, which may reflect the critical role of loading compared to the operated, nonloaded contralateral limb. The increased MAR suggests that loading stimulated new bone formation rather than just maintaining bone volume. The absence of a dose‐dependent response of trabecular bone observed in this study suggests that a range of load magnitudes should be examined for biophysical therapies aimed at augmenting current treatments to enhance long‐term fixation of orthopedic devices. © 2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31: 930–934, 2013
A diary study of credibility assessment in everyday life information activities on the web: Preliminary findings

This study investigates how people's credibility assessment processes have evolved as they engage in increasingly diverse types of online activities beyond seeking for information or reading online news. Using an online activity diary method, information on people's online activities and their associated credibility assessment processes were collected at multiple points throughout the day for three days. This paper reports on a preliminary analysis of 2,471 diary entries received from 333 respondents. Content analysis was applied to people's descriptions of their online activities, yielding 17 different types of information objects and 26 categories of online content. People's credibility judgments were examined on three levels: construct, heuristics, and interaction. The results, although preliminary, indicate that distinct credibility assessment heuristics are in fact emerging as people engage in online activities involving more user-generated and multimedia content. The unique contribution of this paper is its identification of the importance of taking a heuristic approach to credibility assessment by studying a large sample of heavy Internet users within the context of the everyday life information activities they conduct online.
Modulation of nitric oxide‐evoked apoptosis by the p53‐downstream target p21WAF1/CIP1

When produced in excess, the inflammatory mediator nitric oxide (NO) attenuates cell‐cycle progression at the G1 phase in tight correlation with p21WAF1/CIP1 expression, provokes accumulation of the tumor suppressor p53, and initiates apoptosis/necrosis as judged on cell accumulation in the sub‐G1 phase. To verify the role of p21WAF1/CIP1 in modulating cell‐cycle arrest vs. apoptosis, we transfected stably antisense p21WAF1/CIP1‐encoding plasmids. Following NO exposure, accumulation of p21WAF1/CIP1, but not p53, was largely attenuated in antisense p21WAF1/CIP1 transfectants. Moreover, the G1 cell‐cycle arrest was abrogated, and cells were sensitized toward apoptosis compared with parent macrophages. In contrast, antisense elimination of p53 attenuated p53 as well as p21WAF1/CIP1 expression, abolished the G1 cell‐cycle arrest, and prevented apoptosis. We conclude that p21WAF1/CIP1 is a downstream target of p53 in macrophages that modulate the sensitivity toward the immune‐modulator NO.
Surgical site infection following hernia repair in the day care setting of a developing country: a retrospective review.

OBJECTIVE To determine the incidence proportion of surgical site infection following hernia repair in a daycare setting at a tertiary care hospital of a low-income country. METHODS The retrospective audit was done at the Aga Khan University Hospital, Karachi, from June 1, 2008 to May 30, 2009. Patients with age >15 years who underwent Lichenstein's open mesh repair in daycare were included. Surgical Site Infection was labelled if the records revealed any of the following: opening of the wound by the primary surgeon; pain, tenderness and raised temperature of skin; purulent discharge from the wound; if the surgeon had documented it as a surgical site infection. SPSS 16 was used for data analysis. RESULTS After reviewing the retrieved files, 104 patients were found eligible. Of them, 102 (98%) were males. Overall wound-related complications were found in 13 (12.5%), whereas surgical site infection was found in 8 (7.7%) patients. The mean age of those with infections was 38.7+/-8 year, while that of those with no surgical site infection was 47.8+/-18 years. Smoking was found significantly associated with surgical site infection with 5.8 times higher incidence as compared to the non-smokers [OR with 95% CI: 5.6 (1.2, 25.3)]. CONCLUSIONS The incidence of surgical site infection after hernia repair with mesh in a daycare setting at a tertiary care hospital of a low-income country was higher than internationally reported incidence. Smoking was found to be a significant risk factor.
A metaphysics for scientific realism

Scientific realism is the view that our best scientific theories give approximately true descriptions of both observable and unobservable aspects of a mindindependent world. Debates between realists and their critics are at the very heart of the philosophy of science. Anjan Chakravartty traces the contemporary evolution of realism by examining the most promising recent strategies adopted by its proponents in response to the forceful challenges of antirealist sceptics, resulting in a positive proposal for scientific realism today. He examines the core principles of the realist position, and sheds light on topics including the varieties of metaphysical commitment required, and the nature of the conflict between realism and its empiricist rivals. By illuminating the connections between realist interpretations of scientific knowledge and the metaphysical foundations supporting them, his book offers a compelling vision of how realism can provide an internally consistent and coherent account of scientific knowledge.
Outbreak of chickenpox in a Union Territory of North India

Purpose: Primary infection with a varicella-zoster virus (VZV) leads to chickenpox. Though the incidence of the disease has decreased in many developed countries due to the introduction of the varicella vaccine, outbreaks continue to occur in developing countries. Materials and Methods: The present study reports an outbreak of varicella in an urbanised village in the vicinity of Chandigarh City in North India in November 2013. The outbreak was confirmed by the detection of VZV IgM antibodies in serum samples of clinically suspected patients. Vesicular fluid samples were collected from 8 patients with active lesions and tested for VZV DNA by polymerase chain reaction. Blood samples were also collected from 17 healthy controls residing in the same locality and tested for the presence of VZV IgM and IgG antibodies. Results: A total of 18 cases occurred, and the majority of them (67%) were <15 years of age. Of 17 samples collected from patients with the clinically suspected disease, 13 (76.5%) showed the presence of VZV IgM antibodies. Of the healthy controls, 6 were VZV IgM positive and 4 of them developed symptomatic disease on follow-up. VZV DNA was positive in 5/8 (62.5%) of the patients. In one patient, VZV DNA was detected in the absence of an IgM antibody response. Conclusion: The introduction of varicella vaccine in the universal immunisation programme of India may help to prevent these outbreaks; however, the cost-benefit analysis needs to be carried out before making such policies.