Miracle-dz/UniFAR-FTUs huggingface dataset:
Optical Coherence Tomography Angiography: A New Tool in Glaucoma Diagnostics and Research

Optical coherence tomography angiography (OCTA) is a new modality in ocular imaging which provides high resolution view of the vascular structures in the retina and optic nerve head. This technology has the advantages of being noninvasive, rapid and reproducible. OCTA is becoming a valuable tool for evaluating many retinal and optic nerve diseases. This article provides a brief introduction to the technology and its application in the field of glaucoma diagnostics.
Levels Issues in Theory Development, Data Collection, and Analysis

Despite past entreaties to organizational theorists and researchers to address levels issues more carefully, levels issues continue to arouse confusion and controversy within the organizational literature. We highlight three alternative assumptions that underlie the specification of levels of theory throughout organizational behavior: (a) homogeneity within higher level units, (b) independence from higher level units, and (c) heterogeneity within higher level units. These assumptions influence the nature of theoretical constructs and propositions and should, ideally, also influence data collection, analysis, and interpretation. Greater attention to levels issues will strengthen organizational theory development and research.
Build N Burn: Using Fire as a Tool to Evoke, Educate and Entertain

The visceral nature of fire was exploited in the Neolithic and Bronze Age periods in Britain by the burning down of timber buildings and monuments, as well as the cremation of the dead. These big fires would have created memories, perhaps even ‘flashbulb memories’, and this powerful mnemonic aspect of fire was likely of significance to the social and religious lives of individuals, families and communities. This article introduces the Build N Burn concept, where fires are recreated and deployed alongside public talks, performances, experimental archaeology activities and demonstrations by craft specialists to create memorable and informative public events. Three public engagements to date, two on the island of Arran and one in Caithness, both Scotland, are described here. In each case, we constructed replica timber structures inspired by local prehistoric sites, and then burned these down in a free-to-attend public event at dusk, evoking the culmination of a prehistoric festival. Build N Burn has, at its core, the principle of delivering memorable experiences for the public inspired by prehistory, underpinned by research and experiment, using events which draw on cross-sectoral collaboration and working with local communities. This article offers a critical reflection on work to date, and discusses future potential for such activities, utilizing the mnemonic power and transformational potential of fire for public engagement and experimental archaeology.
The Effect of Managerial Ability on Future Stock Price Crash Risk: Evidence from Korea

This study examines the effect of managerial ability on subsequent stock price crash risk using listed firm data in Korea. Compared to some financially advanced countries, the influence of managers is particularly more powerful in Korea, as ownership and management are not effectively separate in most Korean firms. In addition, we considered the effect of large business groups called Chaebol, which is family-run conglomerates with unique corporate governance system that hugely affect the Korean economy. It is important to recognize determinants of the stock price crash risk which would result in doubt on going concern to enhance the company’s sustainable management. Hence, this study focuses on the managerial ability as one of the main factors of the stock price crash risk. We use the measures of firm-specific stock price crash risk based on Hutton et al. (2009). Managerial ability is estimated through a Data Envelopment Analysis (DEA) and tobit regressions following Demerjian et al. (2012). From the empirical tests, there is a negative association between managerial ability and stock price crash risk. This suggests that managers with a higher ability release more voluntary disclosure to signal their ability, ultimately lowering the subsequent stock price crash risk. We also find that firms in large business groups, Chaebol, weaken the negative association between managerial ability and subsequent stock price crash risk.
Spying on the Smart Home: Privacy Attacks and Defenses on Encrypted IoT Traffic

The growing market for smart home IoT devices promises new conveniences for consumers while presenting new challenges for preserving privacy within the home. Many smart home devices have always-on sensors that capture users' offline activities in their living spaces and transmit information about these activities on the Internet. In this paper, we demonstrate that an ISP or other network observer can infer privacy sensitive in-home activities by analyzing Internet traffic from smart homes containing commercially-available IoT devices even when the devices use encryption. We evaluate several strategies for mitigating the privacy risks associated with smart home device traffic, including blocking, tunneling, and rate-shaping. Our experiments show that traffic shaping can effectively and practically mitigate many privacy risks associated with smart home IoT devices. We find that 40KB/s extra bandwidth usage is enough to protect user activities from a passive network adversary. This bandwidth cost is well within the Internet speed limits and data caps for many smart homes.
Efficacy and safety of one intravitreal injection of bevacizumab in diabetic macular oedema

PURPOSE To assess the efficacy, duration of effect and safety of one intravitreal injection of bevacizumab in diabetic macular oedema (DMO). METHODS Bevacizumab (1 mg/0.04 ml) was injected intravitreally into eyes with DMO (29 with and nine without previous treatments). Best corrected visual acuity (BCVA), intraocular pressure and central retinal thickness (CRT) were measured; slit-lamp examination, macular biomicroscopy, optical coherence tomography and fluorescein angiography were performed before and at 2-4, 8 and 12 weeks post-injection. Best corrected VA and CRT were analysed in both groups. RESULTS In the non-pretreated group, mean BCVA improved from 0.76 +/- 0.33 (baseline) to 0.57 +/- 0.30 and 0.54 +/- 0.27 at 2-4 weeks and 8 weeks post-injection, respectively (p = 0.02, p = 0.014, paired t-test). Mean CRT decreased from 632.4 +/- 196.0 microm (baseline) to 392.3 +/- 113.6 microm and 370.4 +/- 141.7 microm at the same time-points, respectively (p = 0.01, p = 0.01). There was no difference in BCVA or CRT at 12 weeks. In the pretreated group, mean BCVA improved from 0.62 +/- 0.30 (baseline) to 0.53 +/- 0.33 at 2-4 weeks post-injection (p = 0.01), and mean CRT decreased from 583.9 +/- 180.7 microm (baseline) to 404.1 +/- 197.9 microm at 2-4 weeks post-injection (p < 0.001). Mean BCVA was unchanged at 8 weeks and 12 weeks post-injection, although mean CRT remained lower at 8 weeks (p = 0.004). No ocular or systemic side-effects developed during follow-up. CONCLUSIONS One intravitreal injection of bevacizumab for DMO seems to be effective and safe in both eyes that have been treated previously and eyes that have not. The therapeutic effect is temporary and repeat treatment may be needed.
Building consensus for provision of breathlessness rehabilitation for patients with chronic obstructive pulmonary disease and chronic heart failure

The study aimed to gain consensus on key priorities for developing breathlessness rehabilitation services for patients with chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF). Seventy-four invited stakeholders attended a 1-day conference to review the evidence base for exercise-based rehabilitation in COPD and CHF. In addition, 47 recorded their views on a series of statements regarding breathlessness rehabilitation tailored to the needs of both patient groups. A total of 75% of stakeholders supported symptom-based rather than disease-based rehabilitation for breathlessness with 89% believing that such services would be attractive for healthcare commissioners. A total of 87% thought patients with CHF could be exercised using COPD training principles and vice versa. A total of 81% felt community-based exercise training was safe for patients with severe CHF or COPD, but only 23% viewed manual-delivered rehabilitation an effective alternative to supervised exercise training. Although there was strong consensus that exercise training was a core component of rehabilitation in CHF and COPD populations, only 36% thought that this was the ‘most important’ component, highlighting the need for psychological and other non-exercise interventions for breathlessness. Patients with COPD and CHF face similar problems of breathlessness and disability on a background of multi-morbidity. Existing pulmonary and cardiac rehabilitation services should seek synergies to provide sufficient flexibility to accommodate all patients with COPD and CHF. Development of new services could consider adopting a patient-focused rather than disease-based approach. Exercise training is a core component, but rehabilitation should include other interventions to address dyspnoea, psychological and education needs of patients and needs of carers.
Hepatitis C Virus Particle Assembly Involves Phosphorylation of NS5A by the c-Abl Tyrosine Kinase*

Background: HCV NS5A regulates viral RNA replication and virus particle assembly. Results: Phosphorylation of NS5A by c-Abl is required for efficient production of infectious HCV particles but not for viral RNA replication. Conclusion: HCV particle assembly involves tyrosine phosphorylation of NS5A. Significance: This study provides the first evidence for the importance of NS5A tyrosine phosphorylation in the HCV life cycle. Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) is thought to regulate the replication of viral RNA and the assembly of virus particles in a serine/threonine phosphorylation-dependent manner. However, the host kinases that phosphorylate NS5A have not been fully identified. Here, we show that HCV particle assembly involves the phosphorylation of NS5A by the c-Abl tyrosine kinase. Pharmacological inhibition or knockdown of c-Abl reduces the production of infectious HCV (J6/JFH1) particles in Huh-7.5 cells without markedly affecting viral RNA translation and replication. NS5A is tyrosine-phosphorylated in HCV-infected cells, and this phosphorylation is also reduced by the knockdown of c-Abl. Mutational analysis reveals that NS5A tyrosine phosphorylation is dependent, at least in part, on Tyr330 (Tyr2306 in polyprotein numbering). Mutation of this residue to phenylalanine reduces the production of infectious HCV particles but does not affect the replication of the JFH1 subgenomic replicon. These findings suggest that c-Abl promotes HCV particle assembly by phosphorylating NS5A at Tyr330.
Residual level of Chromium, Copper and Manganese in Soil and Water of N-24 Parganas (West Bengal) and its Relation to Chevon quality

An increase in human population coupled with urbanization, has resulted for higher demand in meat per capita.Meat and meat products are important for human diet as they provide a great part of nutrients, including necessary trace elements which act as micronutrients. The present study focuses on the concentration of trace elements (chromium, copper and manganese) in the meat of goats (40 weeks age) reared in the three targeted zones of West Bengal, where high heavy metal concentrations in soil and water is a matter of concern. Soil, water and chevon samples were collected from three targeted zones of West Bengal.The meat samples were taken from free range goats grazing locally. Over a span of six months samples were collected, digested and analyzed by atomic absorption spectrophotometry. The mean values of heavy metals in soil samples ranged from 29.96-49.260 ppm of chromium, 14.65 to 38.3 ppm for copper and 198.6 to 482 ppm for manganese. The mean values of heavy metals in water ranged from 0.006-0.02 ppm for chromium, 0.0024 to 0.0180 ppm for copper and 0.068 to 0.436 ppm for manganese . Soil samples revealed high concentration of chromium and copper whereas water samples revealed high concentration of manganese. These levels did not impact the edible quality of meat. Hence advocating that risks associated with chevon consumption from goats (40 weeks age) reared in areas having high heavy metal residual content are negligible and consumption of such meats should not necessarily cause any dilemma. Abstract and
An MRI study of Chlamydia pneumoniae infection in Italian multiple sclerosis patients

We amplified sequences of the Chlamydia pneumoniae (C P) major-outer membrane protein in the cerebrospinal fluid (CSF) from 23 of 107 (21.5%) relapsing-remitting or secondary progressive multiple sclerosis (MS) patients and two of 77 (2.6%) patients with other neurological diseases (OND) (P =0.00022). C P+ patients showed magnetic resonance imaging (MRI) evidence of more active disease (P =0.02) compared to CP-MS patients and tended to have an anticipation of age at disease onset (32.39-12 versus 28.59-10 years; P =ns) causing a longer disease duration (7.59-5 versus 4.49-4 years; P =0.016) at the time of clinical evaluation. These findings, although indirectly, suggest that C P infection of the central nervous system (C NS) might affect disease course in a subgroup of MS patients.
Patterns of loss of enterotoxigenicity by Escherichia coli isolated from adults with diarrhea: suggestive evidence for an interrelationship with serotype

Enterotoxigenic Escherichia coli isolates obtained in Mexico from adult subjects with diarrhea and from healthy controls were examined for the production of heat-stable enterotoxin (ST) and heat-labile enterotoxin (LT) after serial passage in the laboratory. Isolates were found to be either stable for the production of ST and LT or unstable with respect to ST, LT, or both. Unilateral loss of either ST or LT production allowed classification of E. coli isolates into four groups according to stability/instability of enterotoxin production. Fewer serotypes, with more representative isolates, were in group I (stable) than in group IV (completely unstable). Isolates from Dacca, Bangladesh, could be similarly classified into stability groups. There is an apparent relationship between serotype, stability of enterotoxin production, particularly LT, and isolation from diarrhea cases as opposed to isolation from healthy controls.
Unified characterization of RTN and BTI for circuit performance and variability simulation

In small devices, Bias Temperature Instability (BTI) produces discrete threshold voltage (VT) shifts, which are attributed to the charge and discharge of single defects. In this work, the voltage and temperature dependences of charging/discharging of individual defects, considering their stochastic behavior, have been analyzed. From the results, and considering a previously presented BTI physics-based model, the corresponding VT shifts in the device have been obtained and included in a circuit simulator, to evaluate their effects on SRAM cells performance and variability.
The architecture of the human Rad54–DNA complex provides evidence for protein translocation along DNA

Proper maintenance and duplication of the genome require accurate recombination between homologous DNA molecules. In eukaryotic cells, the Rad51 protein mediates pairing between homologous DNA molecules. This reaction is assisted by the Rad54 protein. To gain insight into how Rad54 functions, we studied the interaction of the human Rad54 (hRad54) protein with double-stranded DNA. We have recently shown that binding of hRad54 to DNA induces a change in DNA topology. To determine whether this change was caused by a protein-constrained change in twist, a protein-constrained change in writhe, or the introduction of unconstrained plectonemic supercoils, we investigated the hRad54–DNA complex by scanning force microscopy. The architecture of the observed complexes suggests that movement of the hRad54 protein complex along the DNA helix generates unconstrained plectonemic supercoils. We discuss how hRad54-induced superhelical stress in the target DNA may function to facilitate homologous DNA pairing by the hRad51 protein directly. In addition, the induction of supercoiling by hRad54 could stimulate recombination indirectly by displacing histones and/or other proteins packaging the DNA into chromatin. This function of DNA translocating motors might be of general importance in chromatin metabolism.
Congenital absence of the thymus.

creasing interest in the function of the thymus and its relationship to clinical disease. The thymus has been shown to have a central role in those immunologic mechanisms that are responsible for cellular immunity. In 1965, one of us (A.D.G.) called attention to the syndrome of congenital absence of the thymus with the concurrent congenital absence of the parathyroid glands. ’ In i of infants with this syndrome whom we have studied, thymic aplasia was suspected ante mortem and was proven at the time of autopsy at 17 months of age.2 The association of congenital absence of the thymus and the parathyroids stems from the fact that both structures arise from the third and fourth pharyngeal pouches. Furthermore, one might expect other developmental anomalies of closely related anlage: for example, anomalies of the aortic arch, which arises from the fourth branchial arch, have been noted in this syndrome. Three of our 4 patients with absent thymus had roentgen examinations of the chest during the first week of life. The findings in these roentgenograms form the basis of this report.
An Unusual Cause of Gastrointestinal Bleeding: Gastric Fundic Gland Polyps

The most usual causes of iron deficiency anemia are related to the digestive disease: acute or chronic blood loss (due to cancer or polyp of colon or stomach, peptic ulcer, nonsteroidal anti-inflammatory drugs use, inflammatory bowel disease, vascular lesions) or reduced iron absorption (in celiac disease, small bowel bacterial overgrowth, Whipple’s disease, lymphangiectasia, gastrectomy and gastric atrophy, gut resection or bypass). Fundic gland polyps are not common causes of gastrointestinal bleeding, but in this case we were able to proof that the bleeding was the result of these unusual large polyps. What is reported here is a case of occult gastrointestinal bleeding caused by torsion of sessile polyps in the patient who received chronic low-dose acetylsalicylic acid therapy. The patient was successfully treated with endoscopic resection of largest polyps. This report could be useful in cases of sporadic fundic gland polyps and unrecognized cause of bleeding or iron deficiency anemia; especially in instances in which anticoagulant or low-dose aspirin therapies were applied.
Beamwidth Selection for a Uniform Planar Array (UPA) Using RT-ICM mmWave Clusters

Beamforming is the primary technology to overcome the high path loss in millimeter-wave (mmWave) channels. Hence, performance improvement needs knowledge and control of the spatial domain. In particular, antenna structure and radiation parameters affect the beamforming performance in mmWave communications systems. In order to address the impairments such as beam misalignments, outage loss, tracking inability, blockage, etc., an optimum value of the beamwidth must be determined. In our previous paper, assuming a communication system that creates a beam per cluster, we theoretically investigated the beamwidth-received power relation in the cluster level mmWave channels. We used uniform linear array (ULA) antenna in our analysis. In this paper, we revisit the analysis and update the expressions for the scenario where we use rectangular uniform planar array (R-UPA) antenna. Rectangular beam model is considered to approximate the main lobe pattern of the antenna. For the channel, we derive beamwidth-dependent extracted power expressions for two intra-cluster channel models, IEEE 802.11ad and our previous work based on ray-tracing (RT-ICM). Combining antenna and channel gains, in case of the perfect alignment, we confirm that the optimum beamwidth converges zero. Performing asymptotic analysis of the received power, we give the formulation and insights that the practical nonzero beamwidth values can be achieved although sacrificing subtle from the maximum received power. Our analysis shows that to reach 95% of the maximum power for a typical indoor mmWave cluster, a practical beamwidth of 3.5 deg is enough. Finally, our analysis results show that there is a 13 dB increase in the maximum theoretical received power when UPA is used over ULA. We show that an 8 x 8 UPA can reach 50% of that maximum received power while the received power is still 10 dB larger than the ULA scenario.
Intrathyroidal activated (Ia+) T-lymphocyte CD+ subsets and B cells in Graves' hyperthyroidism respond rapidly to propylthiouracil therapy: demonstration using fine needle aspirates and two-colour laser flow cytometry.

Using a rapid (whole blood lysis) single laser microfluorocytometric technique that permitted the simultaneous analysis of two monoclonal antibody surface markers tagged with different fluorescent dyes, the intrathyroidal (IT) and peripheral blood (PB) activated [Ia+ = DR+] T-lymphocyte CD3+ subsets and [F(ab')2+] B cells were studied in hyperthyroid patients with Graves' disease (GD) before and after 1-4 months of propylthiouracil (PTU) therapy. IT lymphocytes were obtained by serial fine needle aspiration. In untreated patients a marked quantitative (approximately < 10 fold) increase in activated (Ia+ CD3+) T-lymphocytes as well as CD4+ and CD8+ subsets, for IT compared to PB sites, was found. The percentages of Ia+ CD4+ and Ia+ CD8+ within Ia+ CD3+ were not significantly different between the two sources of T cells. F(ab')2+. B cells were significantly increased (approximately 2-3 fold) in IT compared to PB. In hyperthyroid GD patients, PTU therapy induced rapid and specific changes within the Ia+ CD3+ subsets, namely a reduction in the Ia+ CD4+ subset and an increase in the Ia+ CD8+ subset, resulting in a marked decrease in the Ia+ CD4+/Ia+ CD8+ ratio. These changes occurred in association with a reduction in serum T4 and T3 concentration. No significant changes could be detected within the total (predominantly non-activated) CD3+, CD4+ or CD8+ lymphocyte subsets within PB and only a small decrease in the CD4+/CD8+ ratio was demonstrated in IT, following PTU treatment. (ABSTRACT TRUNCATED AT 250 WORDS)
Lumbosacral degenerative stenosis in the dog

Summary Thirty-eight dogs with Hansen type II lumbosacral disc protrusion were treated with epidural infiltration of methylprednisolone acetate between the seventh lumbar vertebra and the sacrum. Epidural infiltration was carried out under C-arm fluoroscopic guidance at standardised intervals for the first three treatments and later on demand. Retrospective evaluation by owner questionnaire found that 79% of the animals were considered to have improved, and 53% were totally cured. Epidural infiltration with methylprednisolone acetate has a clinical outcome comparable to decompressive surgery and can be safely used as a less invasive alternative.