Miracle-dz/UniFAR-FTUs huggingface dataset:
Top-Down Cognitive and Linguistic Influences on the Suppression of Spontaneous Otoacoustic Emissions

Auditory sensation is often thought of as a bottom-up process, yet the brain exerts top-down control to affect how and what we hear. We report the discovery that the magnitude of top-down influence varies across individuals as a result of differences in linguistic background and executive function. Participants were 32 normal-hearing individuals (23 female) varying in language background (11 English monolinguals, 10 Korean-English late bilinguals, and 11 Korean-English early bilinguals), as well as cognitive abilities (working memory, cognitive control). To assess efferent control over inner ear function, participants were presented with speech-sounds (e.g., /ba/, /pa/) in one ear while spontaneous otoacoustic emissions (SOAEs) were measured in the contralateral ear. SOAEs are associated with the amplification of sound in the cochlea, and can be used as an index of top-down efferent activity. Individuals with bilingual experience and those with better cognitive control experienced larger reductions in the amplitude of SOAEs in response to speech stimuli, likely as a result of greater efferent suppression of amplification in the cochlea. This suppression may aid in the critical task of speech perception by minimizing the disruptive effects of noise. In contrast, individuals with better working memory exert less control over the cochlea, possibly due to a greater capacity to process complex stimuli at later stages. These findings demonstrate that even peripheral mechanics of auditory perception are shaped by top-down cognitive and linguistic influences.
Explosive Properties of Reactor-Grade Plutonium

The following discussion focuses on the question of whether a terrorist organization or a threshold state could make use of plutonium recovered from light-water-reactor fuel to construct a nuclear explosive device having a significantly damaging yield. Questions persist in some nonproliferation policy circles as to whether a bomb could be made from reactor-grade plutonium of high burn-up, and if so, whether the task would be too difficult for a threshold state or terrorist group to consider. Although the information relevant to these questions is in the public domain, and has been for a considerable time, it is assembled here for use by policy makers and members of the public who are concerned about preventing the spread of nuclear explosives.
Experimental examination of pollinator-mediated selection in a sexually deceptive orchid

Background and Aims Selection exerted by pollinators on flowers is predicted to occur along two distinct axes. While pollinator attraction to flowers is governed by pollinator preferences, pollen transfer efficiency is mediated by the mechanical fit of pollinators to flower morphology. Although pollinator attraction in sexually deceptive orchids is typically underpinned by floral odour, morphological traits are expected to play a vital role in mechanical fit during floral contact with pollinators. Methods Here we utilize a comprehensive and novel procedure to test for pollinator-mediated selection through mechanical fit with the flower labellum in the orchid Chiloglottis trapeziformis. This approach combines detailed pollinator observations related to plant reproductive fitness with complementary experimental manipulation and phenotypic selection analysis. Key Results Experiments with virgin flowers revealed that pollen removal occurs only during vigorous pseudocopulation. This behaviour involves male wasps that grasp the insectiform callus structure on the labellum while probing the labellum tip in a forward orientation. Both orientation and duration of pseudocopulation were significant predictors of pollen removal, confirming a direct relationship between pollinator behaviour and plant fitness. Controlled floral manipulation that either shortened or elongated the distance between the callus and the labellum tip detected no change in pollinator attraction. The duration of pseudocopulation, however, was significantly reduced on flowers with shortened or elongated callus-tip distances, consistent with stabilizing selection. Phenotypic selection analysis confirmed this prediction in natural populations by uncovering evidence for stabilizing selection on the distance between the callus and the labellum tip. Conclusions Our experimental manipulations and selection analysis in natural populations thus demonstrate stabilizing selection on the distance from the callus to the labellum tip, and illustrate the utility of employing multiple approaches to confirm selection exerted by pollinators on floral form.
Continuous-Time Acquisition of Biosignals Using a Charge-Based ADC Topology

This paper investigates continuous-time (CT) signal acquisition as an activity-dependent and nonuniform sampling alternative to conventional fixed-rate digitisation. We demonstrate the applicability to biosignal representation by quantifying the achievable bandwidth saving by nonuniform quantisation to commonly recorded biological signal fragments allowing a compression ratio of <inline-formula><tex-math notation="LaTeX">$\approx$</tex-math> </inline-formula>5 and 26 when applied to electrocardiogram and extracellular action potential signals, respectively. We describe several desirable properties of CT sampling, including bandwidth reduction, elimination/reduction of quantisation error, and describe its impact on aliasing. This is followed by demonstration of a resource-efficient hardware implementation. We propose a novel circuit topology for a charge-based CT analogue-to-digital converter that has been optimized for the acquisition of neural signals. This has been implemented in a commercially available 0.35 <inline-formula><tex-math notation="LaTeX">$\mu \text{m}$</tex-math></inline-formula> CMOS technology occupying a compact footprint of 0.12 mm<sup>2</sup>. Silicon verified measurements demonstrate an 8-bit resolution and a 4 kHz bandwidth with static power consumption of 3.75 <inline-formula> <tex-math notation="LaTeX">$\mu$</tex-math></inline-formula>W from a 1.5 V supply. The dynamic power dissipation is completely activity-dependent, requiring 1.39 pJ energy per conversion.
Monogenic Disorders of Adrenal Steroidogenesis

Disorders of adrenal steroidogenesis comprise autosomal recessive conditions affecting steroidogenic enzymes of the adrenal cortex. Those are located within the 3 major branches of the steroidogenic machinery involved in the production of mineralocorticoids, glucocorticoids, and androgens. This mini review describes the principles of adrenal steroidogenesis, including the newly appreciated 11-oxygenated androgen pathway. This is followed by a description of pathophysiology, biochemistry, and clinical implications of steroidogenic disorders, including mutations affecting cholesterol import and steroid synthesis, the latter comprising both mutations affecting steroidogenic enzymes and co-factors required for efficient catalysis. A good understanding of adrenal steroidogenic pathways and their regulation is crucial as the basis for sound management of these disorders, which in the majority present in early childhood.
Soft mechanical metamaterials with unusual swelling behavior and tunable stress-strain curves

Soft mechanical metamaterials were designed to offer large negative/positive swelling ratios and tunable stress-strain curves. Soft adaptable materials that change their shapes, volumes, and properties in response to changes under ambient conditions have important applications in tissue engineering, soft robotics, biosensing, and flexible displays. Upon water absorption, most existing soft materials, such as hydrogels, show a positive volume change, corresponding to a positive swelling. By contrast, the negative swelling represents a relatively unusual phenomenon that does not exist in most natural materials. The development of material systems capable of large or anisotropic negative swelling remains a challenge. We combine analytic modeling, finite element analyses, and experiments to design a type of soft mechanical metamaterials that can achieve large effective negative swelling ratios and tunable stress-strain curves, with desired isotropic/anisotropic features. This material system exploits horseshoe-shaped composite microstructures of hydrogel and passive materials as the building blocks, which extend into a periodic network, following the lattice constructions. The building block structure leverages a sandwiched configuration to convert the hydraulic swelling deformations of hydrogel into bending deformations, thereby resulting in an effective shrinkage (up to around −47% linear strain) of the entire network. By introducing spatially heterogeneous designs, we demonstrated a range of unusual, anisotropic swelling responses, including those with expansion in one direction and, simultaneously, shrinkage along the perpendicular direction. The design approach, as validated by experiments, allows the determination of tailored microstructure geometries to yield desired length/area changes. These design concepts expand the capabilities of existing soft materials and hold promising potential for applications in a diverse range of areas.
Niemann-Pick Type C2 Protein Regulates Free Cholesterol Accumulation and Influences Hepatic Stellate Cell Proliferation and Mitochondrial Respiration Function

Liver fibrosis is the first step toward the progression to cirrhosis, portal hypertension, and hepatocellular carcinoma. A high-cholesterol diet is associated with liver fibrosis via the accumulation of free cholesterol in hepatic stellate cells (HSCs). Niemann-Pick type C2 (NPC2) plays an important role in the regulation of intracellular free cholesterol homeostasis via direct binding with free cholesterol. Previously, we reported that NPC2 was downregulated in liver cirrhosis tissues. Loss of NPC2 enhanced the accumulation of free cholesterol in HSCs and made them more susceptible to transforming growth factor (TGF)-β1. In this study, we showed that knockdown of NPC2 resulted in marked increases in platelet-derived growth factor BB (PDGF-BB)-induced HSC proliferation through enhanced extracellular signal-regulated kinases (ERK), p38, c-Jun N-terminal kinases (JNK), and protein kinase B (AKT) phosphorylation. In contrast, NPC2 overexpression decreased PDGF-BB-induced cell proliferation by inhibiting p38, JNK, and AKT phosphorylation. Although NPC2 expression did not affect caspase-related apoptosis, the autophagy marker light chain 3β (LC3B) was decreased in NPC2 knockdown, and free cholesterol accumulated in the HSCs. The mitochondrial respiration functions (such as oxygen consumption rate, ATP production, and maximal respiratory capacity) were decreased in NPC2 knockdown, and free cholesterol accumulated in the HSCs, while NPC2-overexpressed cells remained normal. In addition, NPC2 expression did not affect the susceptibility of HSCs to lipopolysaccharides (LPS), and U18666A treatment induced free cholesterol accumulation, which enhanced LPS-induced Toll-like receptor 4 (TLR4), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) p65 phosphorylation, interleukin (IL)-1 and IL-6 expression. Our study demonstrated that NPC2-mediated free cholesterol homeostasis controls HSC proliferation and mitochondrial function.
Optimal Marketing Strategies for the Acquisition and Retention of Service Subscribers

In this paper, we propose a diffusion model for a subscription service. The evolution over time of the number of subscribers is governed by a differential equation combining two processes—namely, a customer acquisition process and a customer attrition process. Assuming profit-maximization behavior of the firm, we use dynamic programming to optimize the customer equity and determine optimal customer relationship marketing expenditures. We implement an augmented Kalman filter with continuous state and discrete observations to estimate the model’s parameters using market data of two well-known companies in the telecommunications sector. To the best of our knowledge, this is the first paper to model acquisition and retention efforts in the context of a diffusion model. By doing so, we extend the literature on product diffusion to services—that is, beyond its traditional area of durable (and occasionally nondurable) products. By the same token, we contribute to the literature on customer relationship marketing.
Distinct Dimensions Defining the Adult ADHD Self-Report Scale: Implications for Assessing Inattentive and Hyperactive/Impulsive Symptoms

There has been growing interest in studying attention-deficit/hyperactivity disorder (ADHD) in adulthood as a result of research indicating that ADHD often persists into adulthood and frequently is comorbid with other psychiatric disorders. Adult ADHD symptoms are most commonly assessed via self-report, but prior research examining the structure of self-reported adult ADHD symptoms has yielded discrepant results. Explicating the factor structure of ADHD symptom measures is essential to determine if such self-report measures assess symptom dimensions showing distinctive relations with other psychopathology and psychosocial functioning. Consequently, we examined the structure of adult ADHD symptoms in a large sample of adult outpatients (N = 1,094). Symptoms were assessed via the Adult ADHD Self-Report Scale (ASRS; Kessler et al., 2005), which has become the most widely used self-report ADHD measure. Additionally, we extended prior research by examining the relations for emergent ADHD dimensions with other psychopathology and psychosocial impairment. Results indicated that the ASRS’s items define a bifactor structure with specific dimensions of inattentiveness, motor hyperactivity/impulsivity, and verbal hyperactivity/impulsivity. Our results indicate that specific ADHD factors show distinctive relations in some ways. For example, verbal hyperactivity/impulsivity showed negative relations with major depressive disorder, whereas inattentiveness showed positive relations with major depression. These results highlight the need for future research determining the extent to which making distinctions among various ADHD symptom types (i.e., distinguishing motor and verbal hyperactivity/impulsivity) is empirically warranted and clinically useful.
Early Holocene loessic colluviation in northwest England: new evidence for the 8.2 ka event in the terrestrial record?

Vincent, P. J., Lord, T. C. , Telfer, M. W. & Wilson, P. 2010: Early Holocene loessic colluviation in northwest England: new evidence for the 8.2 ka event in the terrestrial record? Boreas, 10.1111/j.1502‐3885.2010. 00172.x. ISSN 0300‐9483.
Molecular and Pathological Features of Gastric Cancer in Lynch Syndrome and Familial Adenomatous Polyposis

Lynch syndrome (LS) and familial adenomatous polyposis (FAP) are autosomal dominant hereditary diseases caused by germline mutations leading to the development of colorectal cancer. Moreover, these mutations result in the development of a spectrum of different tumors, including gastric cancers (GCs). Since the clinical characteristics of GCs associated with LS and FAP are not well known, we investigated clinical and molecular features of GCs occurring in patients with LS and FAP attending our Institution. The Hereditary Tumor Registry was established in 1994 at the Department of Oncologic Gastroenterology, CRO Aviano National Cancer Institute, Italy. It includes 139 patients with LS and 86 patients with FAP. Patients were recruited locally for prospective surveillance. Out of 139 LS patients, 4 developed GC—3 in the presence of helicobacter pylori infection and 1 on the background of autoimmune diseases. All GCs displayed a high microsatellite instability (MSI-H) and loss of related mismatch repair (MMR) protein. One of the FAP patients developed a flat adenoma, displaying low-grade dysplasia at the gastric body, and another poorly differentiated adenocarcinoma with signet ring cells like Krukenberg without HP infection. LS carriers displayed a risk of GC. The recognition of HP infection and autoimmune diseases would indicate those at higher risk for an endoscopic surveillance. Regarding FAP, the data suggested the need of suitable endoscopic surveillance in long survivals with diffuse fundic gland polyps.
'Look this way': Using gaze maintenance to facilitate the detection of children's false reports

Summary In two experiments, we investigated whether imposing a secondary task is an effective technique for detecting child deceit. First, 85 children aged 8 to 11 years old provided either a true or false report of a recent school event. At interview, some children were asked to gaze towards either the interviewer's face (IF) or a teddy bear's face (TF), whereas some children were given no gaze instruction. In both the IF and TF conditions, lie-tellers provided significantly fewer details than truth-tellers. A total of 192 adult evaluators then judged the credibility of 10 children's reports from one of the three ‘gaze’ conditions with and without guidance on level of detail. Evaluators discriminated truths from lies successfully when judging children instructed to look at IF, but not when children were asked to gaze towards TF. Evaluators who received guidance demonstrated better discrimination between true and false reports than evaluators who received no such information. Copyright © 2016 John Wiley & Sons, Ltd.
Electronic properties of Fabre charge-transfer salts under various temperature and pressure conditions

Using density functional theory, we determine parameters of tight-binding Hamiltonians for a variety of Fabre charge transfer salts, focusing, in particular, on the effects of temperature and pressure. Besides relying on previously published crystal structures, we experimentally determine two new sets of structures: (TMTTF)2SbF6 at different temperatures and (TMTTF)2PF6 under various hydrostatic pressures. We find that a few trends in the electronic behavior can be connected to the complex phase diagram shown by these materials. Decreasing temperature and increasing pressure cause the systems to become more two dimensional. We analyze the importance of correlations by considering an extended Hubbard model parameterized using Wannier orbital overlaps and show that while charge order is strongly activated by the intersite Coulomb interaction, the magnetic order is only weakly enhanced. Both orders are suppressed when the effective pressure is increased.
Barycentric Representation and Metric Learning for Facial Expression Recognition

In this paper, we tackle the problem of dynamic facial expression recognition. An affine-invariant facial shape representation based on barycentric coordinates is proposed and related to the Grassmannian representation. Unlike the latter, the barycentric representation allows us to work directly on Euclidean space and apply a metric learning algorithm to find a suitable metric that is discriminative enough to compare facial shapes under different expressions. Finally, we exploit the learned metric in a machinery combining a Dynamic Time Warping (DTW) phase and a pairwise proximity function SVM classifier for a rate-invariant classification of the facial sequences. Experiments on the AFEW dataset show the effectiveness of our approach while exploiting only geometric features.
Two new triterpenoids with antimicrobial activity from the leaves and twigs of Orophea yunnanensis

Abstract Two new triterpenoids, 3-O-(4’,5’-dihydroxybenzoyl)-lup-20(29)-en (1) and 3-O-(6’-desmethysyringyl)-13α-methyl-27-norolean-14-en-3β-ol (2), were isolated from the leaves and twigs of Orophea yunnanensis. Their structures were identified by extensive spectroscopic experiments (NMR and MS) and comparison with literature data. Compounds 1 and 2 exhibited the moderate inhibitory activity against Sclerotinia sclerotiorum, Ceratocystis fimbriata and Verticillium dahliae Kleb with MIC values from 50 to 25 μg/mL, and also displayed the weak activity selectively against tested bacteria strains with MIC values from 100 to 50 μg/mL.
Novel MeCP 2 Isoform-Specific Antibody Reveals the Endogenous MeCP 2 E 1 Expression in Murine Brain , Primary Neurons and Astrocytes

Rett Syndrome (RTT) is a severe neurological disorder in young females, and is caused by mutations in the X-linked MECP2 gene. MECP2/Mecp2 gene encodes for two protein isoforms; MeCP2E1 and MeCP2E2 that are identical except for the Nterminus region of the protein. In brain, MECP2E1 transcripts are 10X higher, and MeCP2E1 is suggested to be the relevant isoform for RTT. However, due to the unavailability of MeCP2 isoform-specific antibodies, the endogenous expression pattern of MeCP2E1 is unknown. To gain insight into the expression of MeCP2E1 in brain, we have developed an antiMeCP2E1 antibody and validated its specificity in cells exogenously expressing individual MeCP2 isoforms. This antibody does not show any cross-reactivity with MeCP2E2 and detects endogenous MeCP2E1 in mice brain, with no signal in Mecp2 y/2 null mice. Additionally, we show the endogenous MeCP2E1 expression throughout different brain regions in adult mice, and demonstrate its highest expression in the brain cortex. Our results also indicate that MeCP2E1 is highly expressed in primary neurons, as compared to primary astrocytes. This is the first report of the endogenous MeCP2E1 expression at the protein levels, providing novel avenues for understanding different aspects of MeCP2 function. Citation: Zachariah RM, Olson CO, Ezeonwuka C, Rastegar M (2012) Novel MeCP2 Isoform-Specific Antibody Reveals the Endogenous MeCP2E1 Expression in Murine Brain, Primary Neurons and Astrocytes. PLoS ONE 7(11): e49763. doi:10.1371/journal.pone. 0049763 Editor: Nicoletta Landsberger, University of Insubria, Italy Received July 30, 2012; Accepted October 12, 2012; Published November 19, 2012 Copyright: 2012 Zachariah et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: This work is supported by funds from the Manitoba Institute of Child Health (MICH) Small Grant and Operating Funds, Scottish Rite Charitable Foundation of Canada (SRCFC, Grant 10110), Manitoba Health Research Council (MHRC) Establishment and Operating Funds, and Health Sciences Centre Foundation (HSCF) Grant. RMZ is a recipient of MHRC-MICH Studentship Award and CE is a recipient of MHRC-UMGF Studentship Award. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: The authors have declared that no competing interests exist. * E-mail: rastegar@cc.umanitoba. ca . These authors contributed equally to this work.