Miracle-dz/UniFAR-FTUs huggingface dataset:
Gender Differences in the Pharmacological Actions of Pegylated Glucagon-Like Peptide-1 on Endothelial Progenitor Cells and Angiogenic Precursor Cells in a Combination of Metabolic Disorders and Lung Emphysema

In clinical practice, the metabolic syndrome (MetS) is often associated with chronic obstructive pulmonary disease (COPD). Although gender differences in MetS are well documented, little is known about sex-specific differences in the pathogenesis of COPD, especially when combined with MetS. Consequently, it is not clear whether the same treatment regime has comparable efficacy in men and women diagnosed with MetS and COPD. In the present study, using sodium glutamate, lipopolysaccharide, and cigarette smoke extract, we simulated lipid metabolism disorders, obesity, hyperglycemia, and pulmonary emphysema (comorbidity) in male and female C57BL/6 mice. We assessed the gender-specific impact of lipid metabolism disorders and pulmonary emphysema on angiogenic precursor cells (endothelial progenitor cells (EPC), pericytes, vascular smooth muscle cells, cells of the lumen of the nascent vessel), as well as the biological effects of pegylated glucagon-like peptide 1 (pegGLP-1) in this experimental paradigm. Simulation of MetS/COPD comorbidity caused an accumulation of EPC (CD45−CD31+CD34+), pericytes, and vascular smooth muscle cells in the lungs of female mice. In contrast, the number of cells involved in the angiogenesis decreased in the lungs of male animals. PegGLP-1 had a positive effect on lipids and area under the curve (AUC), obesity, and prevented the development of pulmonary emphysema. The severity of these effects was stronger in males than in females. Furthermore, PegGLP-1 stimulated regeneration of pulmonary endothelium. At the same time, PegGLP-1 administration caused a mobilization of EPC (CD45−CD31+CD34+) into the bloodstream in females and migration of precursors of angiogenesis and vascular smooth muscle cells to the lungs in male animals. Gender differences in stimulatory action of pegGLP-1 on CD31+ endothelial lung cells in vitro were not observed. Based on these findings, we postulated that the cellular mechanism of in vivo regeneration of lung epithelium was at least partly gender-specific. Thus, we concluded that a pegGLP-1-based treatment regime for metabolic disorder and COPD should be further developed primarily for male patients.
COLD TOLERANCE OF BANANA FRUITS OF DIFFERENT CULTIVARS

The objective of this work was to evaluate the tolerance of fruits of different banana cultivars to low temperature storages. Fruits of the cultivars Nanicão (AAA), Prata (AAB), Vitória (AAAB), Maçã (AAB) and Caipira (AAA) were used. Clusters of three fruits were kept in cold storage for 7, 14 and 21 days, with average temperature of 10.53±0.37°C and relative humidity of 85%. Subsequently, the clusters were transferred to temperatures of 22±0.39°C and evaluated for 16 days. The fruits of all cultivars remained green after 21 days of storage at 10.53±0.37°C. Fruits of the cultivar Nanicão did not completely ripened after transferred to the 22°C storage, when stored for 7 days at low temperature. These fruits were firmer, with green peel and low soluble solids and titratable acidity. The fruits of all cultivars complete the ripening when transferred to room temperature after 21 days of cold storage. Chilling injuries increased with cold storage time in all cultivars. The cultivars Nanicão, Caipira and Maçã had more symptoms of chilling injury, while Prata and Vitória were more tolerant to the cold storage (10.53°C) for up to 21 days, showing normal ripening after transferred to the 22±0.39°C storage.
Neuroprotective Effects of Boric Acid against Fluoride Toxicity on Rat Synaptosomes

Objective: Fluoride toxicity primarily contributes to the production of reactive oxygen and nitrogen derivatives, trigger the cell death pathways by causing lipid peroxidation and DNA damage. Boric acid (BA) contributes to preservation of membrane integrity and function and maintenance of redox balance due to its high affinity to some metabolites in the organism. The aim of this study was to investigate the protective effect of BA on neurodegenerative processes against the toxic effects of sodium fluoride (NaF) administered at different doses on rat brain synaptosomes. Material and Methods: Synaptosomes obtained from the rat frontal cortex were administered at different doses of sodium fluoride (NaF) to determine the most toxic dose of NaF. Determined toxic dose of NaF for synaptosomes and BA concentrations were administered in vitro at 37°C for 30min and then the parameters of malondialdehyde (MDA) level, superoxide dismutase (SOD) activity, Na/K ATPase activity and DNA fragmentation value were measured spectrophotometrically. Results: There was a statistically significant difference between measured parameters, when the 80mg/L NaF group was compared with the control group. We found that 10 and 25 mM BA treatment provided a significant improvement in MDA, SOD, Na/K ATPase and DNA fragmentation compared to the 80mg/L NaF group. The 5 mM BA concentration was not found effective dose according to other doses. Conclusion: In conclusion, BA has potential for neuroprotective effects against cellular damage caused by NaF. The results suggest that the BA can be a neuroprotective therapeutic agent for fluoride toxicity.
The Effect of Store Atmosphere and Packaging Design toward Impulsive Buying with Shopping Lifestyle As a Moderating Variable at Carrefour in Jakarta

Thisresearchwasconductedtoexaminethe factorsthatinﬂuenceimpulsivebuying in Carrefour Jakarta consumers, which consists of shopping lifestyle, store atmosphere and packaging design. This study uses survey methods by distributing questionnaires. The population of this study consisted of Carrefour Jakarta consumers, while the number of samples was 96 people. Sample selection is done using random sampling techniques.ThedataanalysistechniqueusedinthisstudyusesSEMwiththeWarpPLS analysis tool. The results of the study prove that store atmosphere does not have a signiﬁcant effect on impulsive buying. Packaging design has a positive and signiﬁcant effect on impulsive buying. Store atmosphere has a signiﬁcant effect on impulsive buying with shopping lifestyle as a moderating variable. But shopping lifestyle cannot moderate the packaging design relationship to impulsive buying. The contribution of this research is to see the role of shopping lifestyle in moderating store atmosphere and packaging design towards impulsive buying.
Occurrence of Tephritid Fruit Flies with Intermediate morphologies of Bactrocera carambolae and B.papayae (Diptera: Tephritidae) in Selangor, Peninsular Malaysia

Background: Tephritid fruit flies, Bactrocera carambolae(Drew and Hancock) and Bactrocera papayae (Drew and Hancock) belonging to the B. Dorsalis complex are key pests of valuable fruits in Southeast Asia. Control of these pests is often limited by difficulties on their identification that have been increasing due to recent occurrences of species with morphological characteristics of B. carambolaeand B. papayae (hereafter known as intermediates). Whilst field observations of mating between B. Carambolae and B. Papayae have not been documented, it was believed that this phenomenon had occurred through trapping of adult fruit flies with intermediate morphologies of the two mentioned species. This was also substantiated from results of laboratory crossing between B. Carambolae and B. papayae. Objective: A study was conducted to investigate the occurrence of intermediates and its proportion from their parental stocks based on field collection of flies infested starfruits, Averrhoa carambola L. and methyl eugenol-baited traps. Results: A total of 7,144 Bactrocera fruit flies were collected from infested fruits and another 12,522 male flies from traps were collected. A high proportion of intermediates (63%) were trapped whilst 25% of the flies from infested fruits accounted for intermediates. Conclusion: This study suggested that B. carambolae,B. Papayae along with their intermediates are pests of economic importance to starfruit in Malaysia. The study also has reported the predominance of B. Carambolae from damaged fruits and intermediates from methyl eugenol trapping capture; indicating that B. Carambolae is a major fruit fly species infesting starfruit however, intermediates are found in high proportion in fruit field environment.
Synthesis and Characterization of N-Methyl Fatty Hydroxamic Acids from Ketapang Seed Oil Catalyzed by Lipase

N-methyl fatty hydroxamic acid (N-MFHA), which is a derivative of hydroxamic acid (HA), was synthesized from ketapang seed oil (Terminalia catappa L.). In general, HAs have wide applications due to their chelating properties and biological activities. N-MFHAs were synthesized using immobilized lipase (Lipozyme TL IM) in biphasic medium which was the ketapang seed oil dissolved in hexane and N-methylhydroxylamine dissolved in water. The products were characterized through color testing and FT-IR spectroscopy after purification. Various factors affecting the enzyme activity investigated in the study included the effect of incubation time, the amount of lipase used, and the temperature. On the basis of the results, the optimum conditions for the synthesis of N-MFHA obtained are 25 h of incubation time, a temperature of 40 °C, and a ratio of 1:100 for the amount of enzyme (g)/oil (g). At the optimum conditions of the reaction, 59.7% of the oils were converted to N-MFHA.
Corpus-Assisted Study of Discursive Practices in Russian-language Car Advertisements

Even though the advertising discourse has been extensively researched, there is a lack of corpus-assisted studies in this field with regard to Russian-language advertising. The paper addresses the gap by using the corpus approach to provide insights into discursive practices in Russian-language car advertisements through investigation of the keywords identified with SketchEngine software tool. The research draws on the corpus of approximately 80,000 words that contains Russianlanguage advertisements available from websites of car dealers in Russia, which is divided into three sub-corpora comprising texts for cars in different price segments. To complete a comparative analysis that would bring out similarities and differences in the advertising strategies and reveal nuances in patterns of meaning, the key word data in each sub-corpus were compared against each other. The results show that lexical choices might be indicative of different discursive practices revealing distinctive sets of cultural values used for pragmatic purposes. Based on a close reading of the advertisements and a search for discursive tendencies, common and specific conceptual metaphors employed in featuring an automobile have been revealed. It was found that though the conceptualization of car rests on similar metaphors across the corpus, they have different entailments and metaphoric interpretation in different price categories. Keywords—corpus linguistics; advertising discourse; discursive practice; conceptual metaphor.
PFKFB3 Inhibition Attenuates Oxaliplatin-Induced Autophagy and Enhances Its Cytotoxicity in Colon Cancer Cells

6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 (PFKFB3), a glycolytic enzyme highly expressed in cancer cells, has been reported to participate in regulating metabolism, angiogenesis, and autophagy. Although anti-cancer drug oxaliplatin (Oxa) effectively inhibits cell proliferation and induces apoptosis, the growing resistance and side-effects make it urgent to improve the therapeutic strategy of Oxa. Although Oxa induces the autophagy process, the role of PFKFB3 in this process remains unknown. In addition, whether PFKFB3 affects the cytotoxicity of Oxa has not been investigated. Here, we show that Oxa-inhibited cell proliferation and migration concomitant with the induction of apoptosis and autophagy in SW480 cells. Both inhibition of autophagy by small molecule inhibitors and siRNA modification decreased the cell viability loss and apoptosis induced by Oxa. Utilizing quantitative PCR and immunoblotting, we observed that Oxa increased PFKFB3 expression in a time- and dose-dependent manner. Meanwhile, suppression of PFKFB3 attenuated both the basal and Oxa-induced autophagy, by monitoring the autophagic flux and phosphorylated-Ulk1, which play essential roles in autophagy initiation. Moreover, PFKFB3 inhibition further inhibited the cell proliferation/migration, and cell viability decreased by Oxa. Collectively, the presented data demonstrated that PFKFB3 inhibition attenuated Oxa-induced autophagy and enhanced its cytotoxicity in colorectal cancer cells.
Post-surge structural glaciology of the ice margin of Múlajökull, central Iceland, and composition and distribution of geometrical ridges in the forefield

This thesis deals with the structural glaciology of the ice margin of Múlajökull, a surge-type glacier in central Iceland, and the distribution and composition of till ridges that are exposed in the immediate foreland. Detailed structural mapping, glacial geological and geomorphological methods, drone and aerial images, photogrammetry and remote sensing are used to investigate the structural architecture of Múlajökull and the impact of its latest surge on the glacier surface. The mapping reveals that Múlajökull comprises a rapidly flowing central section bounded by slower flowing sections on either side. The boundary between these sections is marked by a series of poorly to well-developed brittle shear zones characterized by sigmoidal, en-échelon tension fissures, which can be used to establish the sense of shear within the ice. Analysis of these brittle deformation structures reveals a flow pattern of the Múlajökull margin that can be linked to a complex interplay between subglacial topography and glacier flow. The subglacial topography is characterized by an overdeepening that is delimited by an arcuate ridge near the present (2015) ice margin, and a series of elongate streamlined bedforms (drumlins) in the ice-marginal zone. A study of sedimentary ridges immediately in front of the present glacier margin shows that they are mainly composed of massive diamiction containing blocky clasts and localized pockets of sorted sediments. The distribution and orientation of these ridges has been correlated with the fracture pattern on the surface of Múlajökull. This indicates that the majority of these ridges formed through the squeezing up of mobile sub-glacial sediments (till) into open longitudinal fractures. Transverse ridges most likely represent seasonal, small push moraines. The study widens the understanding of structural flow dynamics in surging piedmont glaciers and the landform assemblage associated with these glaciers. The relationship between ice surface structures and landforms exposed upon ice retreat is still poorly understood but may have bearing on our understanding of ice flow within both past and present glaciers and ice sheets.
ASSESSMENT OF POTENTIAL DRUG INTERACTIONS AMONG HOSPITALIZED PATIENTS IN NEUROLOGY DEPARTMENT IN TERTIARY CARE HOSPITALS

Objective: This research was instigated to determine and assess the prevalence, severity, type, and the total number of potential drug interactions in the neurology department of two hospitals in India. Methods: The data were collected from the prescriptions and by patient history interview on a daily basis. The drug-drug interactions (DDIs) were identified using Micromedex® database-2.7 and drugs.com. Results: The drug interactions were influenced by a plethora of risk factors: Gender, age, comorbidities, length of hospital stay, and the neurological condition. The study was comprised 320 patients, among 196 patients were identified with potential DDIs (PDDIs), and a total of 450 PDDIs were observed. The prevalence of PDDIs according to the severity was major (42.6%), moderate (45.11%), and minor (12.22%). Conclusion: To lessen PDDIs, the range of medications for the patients must be properly managed, and it is encouraged to remove all medicines without therapeutic advantage, intention, and an indication.
The Assessment of Pragmatic Knowledge in the Online General IELTS-Practice Resources: A Corpus Analysis of Writing Tasks

Motivated by the concept of Communicative Language Ability and the eminence of the IELTS exam, this study intended to scrutinize the representation of functional knowledge (FK) and socio-linguistic knowledge (SK) as sub-components of pragmatic knowledge in the writing performances of both tasks of the online General IELTS-practice resources across three band scores. This quantitative inter-scores/intra-tasks and inter-tasks investigation aimed to reveal firstly whether the writers of three band scores 7, 8, and 9 differed from each other in their FK and SK level, and secondly whether the tasks differed in activating them. This study adopted a taxonomy of five illocutionary acts and 20 register features to investigate representation of FK and SK in a wellestablished corpus of 180 writing performances through both manual analysis and Multidimensional Analysis Tagger software. While the results of statistical analyses revealed no FK differences between the bands in task one (T1), T2‟s higher bands involved more functional features because of the expression of a diverse range of psychological states, no speaker‟s involvement, and less commitment to a future course of actions. Furthermore, socio-linguistically, band 9 scripts encompassed more logical relations, but conversational and spoken style in T1 and more integration, less simplified structures and ego-involvement in T2. The inter-task analyses uncovered T1‟s greater activation of FK through self-mentions, others involvement, emotion, and intention expression. Nevertheless, when it came to SK register features, T2 overdid in both spoken and written genre elements except in persuasion, writers‟ involvement, mental acts expression, and interactive discourse creation.
Importance of isomerization reactions for the OH radical regeneration from the photo-oxidation of isoprene investigated in the atmospheric simulation chamber SAPHIR

<p>Theoretical, laboratory and chamber studies have shown fast regeneration of hydroxyl radical (OH) in the photochemistry of isoprene largely due to previously disregarded unimolecular reactions which were previously thought not to be important under atmospheric conditions. Based on early field measurements, nearly complete regeneration was hypothesized for a wide range of tropospheric conditions, including areas such as the rainforest where slow regeneration of OH radicals is expected due to low concentrations of nitric oxide (NO). In this work the OH regeneration in the isoprene oxidation is directly quantified for the first time through experiments covering a wide range of atmospheric conditions (i.e. NO between 0.15 and 2 ppbv and temperature between 25 and 41&#176;C) in the atmospheric simulation chamber SAPHIR. These conditions cover remote areas partially influenced by anthropogenic NO emissions, giving a regeneration efficiency of OH close to one, and areas like the Amazonian rainforest with very low NO, resulting in a surprisingly high regeneration efficiency of 0.5, i.e. a factor of 2 to 3 higher than explainable in the absence of unimolecular reactions. The measured radical concentrations were compared to model calculations and the best agreement was observed when at least 50% of the total loss of isoprene peroxy radicals conformers (weighted by their abundance) occurs via isomerization reactions for NO lower than 0.2 parts per billion (ppbv). For these levels of NO, up to 50% of the OH radicals are regenerated from the products of the 1,6 &#945;-hydroxy-hydrogen shift (1,6-H shift) of Z-&#948;-RO<sub>2 </sub>radicals through photolysis of an unsaturated hydroperoxy aldehyde (HPALD) and/or through the fast aldehyde hydrogen shift (rate constant ~10 s<sup>-1</sup> at 300K) in di-hydroperoxy carbonyl peroxy radicals (di-HPCARP-RO<sub>2</sub>), depending on their relative yield. The agreement between all measured and modelled trace gases (hydroxyl, hydroperoxy and organic peroxy radicals, carbon monoxide and the sum of methyl vinyl ketone, methacrolein and hydroxyl hydroperoxides) is nearly independent on the adopted yield of HPALD and di-HPCARP-RO<sub>2</sub> as both degrade relatively fast (< 1 h), forming OH radical and CO among other products. Taking into consideration this and earlier isoprene studies, considerable uncertainties remain on the oxygenated products distribution, which affect radical levels and organic aerosol downwind of unpolluted isoprene dominated regions. </p>
Identification of Trichophyton mentagrophytes strains isolated from patients with dermatophytosis

According to epidemiological, clinical and mycological criteria, it has long been admitted that the Trichophyton mentagrophytes species includes two varieties: a zoophilic variety (var. mentagrophytes) and an anthropophilic variety (var. interdigital) that involve the upper and the lower part of the body respectively. The further application of molecular techniques to the characterization of dermatophyte strains showed that this classification is unreliable. The aim of our study was to assess the usefulness of PCR-RFLP (restriction fragment length polymorphism) and sequencing in the characterization of T. mentagrophytes strains taken from Tunisian patients. The study was carried out in 2008 in the laboratory of Parasitology-Mycology of Farhat Hatched hospital, Sousse, Tunisia. A total of 133 strains were isolated from 133 patients addressed to the laboratory for dermatological lesions very evocative of dermatomycosis. Eighty strains were isolated from lesions located on the lower part of the body (onychomycosis, tinea pedis) and 53 strains from the upper part of the body (tinea capitis, tinea corporis). All strains were submitted to mycological examination (direct microscopic examination, and culture on Sabered medium) and further investigated by using RFLP analysis of the PCR amplified ITS1-5.8 s and ITS2 region of the ribosomal DNA and the MvaI restriction enzyme. In addition, 20 strains were further submitted to a sequencing of the ITS1-5.8 s and ITS2 region. On the basis of mycological criteria all strains were diagnosed as T. mentagrophytes. All strains produced the same RFLP pattern and were identified as T. mentagrophytes interdigital regardless of the location of lesions. Out of the 20 sequenced strains, five were found anthropophilic and 15 were zoophilic. In conclusion, all strains provisionally diagnosed as T. mentagrophytes on the basis of mycological criteria were shown to belong to T. interdigital by using PCR-RFLP and sequencing irrespective of the site of lesions. The predominance of zoophilic strains needs further investigation. Keywords: Dermatophytes; Trichophyton mentagrophytes; PCR-RFLP; Sequencing; Phenotypic features