Miracle-dz/UniFAR-FTUs huggingface dataset:
Erythrogenic toxin type B and its precursor isolated from nephritogenic streptococci induce leukocyte infiltration in normal rat kidneys.

BACKGROUND Leukocyte infiltration is a common feature in renal biopsies from patients with acute poststreptococcal glomerulonephritis (APSGN). Cationic streptococcal erythrogenic toxin type B (ETB) and its precursor (ETBP) have been implicated in the pathogenesis of the disease, and the presence of ETB has been evidenced in renal biopsies from patients with APSGN. The present studies were performed to determine the effect of the ETBP and ETB on renal leukocyte infiltration and the mechanism(s) implicated in the phenomenon. METHODS Male Sprague-Dawley rats were injected intrarenally with 100 microg of ETB or ETBP. Animals were sacrificed at 1, 6 and 24 h after injection and renal samples were studied by indirect immunofluorescence for the presence of leukocyte common antigen (LCA+) cells, C3, monocyte chemotactic protein-1 (MCP-1) and intercellular adhesion molecule-(ICAM-1), and by direct immunofluorescence for the presence of immunoglobulins. ETB and ETBP were tested for chemotactic effect and migration inhibition factor (MIF) activity by chemotaxis under agarose and agarose microdroplet methods, respectively. Streptococcal proteins were also tested for the capacity to induce MIF activity in rat glomerular cultures. To test for the influence of cationic charge on renal LCA+ cell infiltration, rats were injected with cationized ferritin or polyethyleneimine (PEI) and sacrificed 1 h later. RESULTS An increased number of LCA+ cells was found in glomeruli and interstitial areas in ETB- or ETBP-injected animals. ETB and ETBP showed chemotactic and MIF activity on neutrophils and macrophages, and ETBP induced MIF activity in supernatants of glomerular cultures. Data obtained from C3, MCP-1, ICAM-1 or immunoglobulin renal staining in experimental animals were not significantly different when compared to control values. Cationized compounds failed to induce LCA+ cell infiltration; however, an increased number of glomerular LCA+ cells was observed after PEI perfusion. CONCLUSIONS ETB and ETBP induce renal LCA+ cell infiltration during a short period after intrarenal injection, and this finding could be mediated by chemotactic and MIF activities. These observations could be relevant in the early events of pathogenesis of APSGN.
Declining HIV/AIDS mortality in New York City.

BACKGROUND New York City has only 3% of the U.S. population but has reported nearly 16% of all AIDS cases. METHODS This is an observational study using the New York City vital events and AIDS case surveillance registries to describe trends in HIV/AIDS mortality from 1983 through June 30, 1998. RESULTS Annual HIV/AIDS deaths increased steadily until stabilizing at 7046 in 1995, declined 29% to 4998 in 1996, and declined 47% to 2625 in 1997. Comparing data from 1997 with those from 1995, declines occurred in all demographic groups and in all major HIV transmission categories: 74% in men who have sex with men, 68% in injecting drug users, and 64% in heterosexuals. In the first 6 months of 1998, declines were smaller than they had been in previous 6-month intervals in all demographic groups except Hispanic males and those between 35 and 44 years of age. From 1995 to the first 6 months of 1998, the number of people living with AIDS in New York City increased 22% (from 32,692 to 39,976). CONCLUSIONS The precipitous 63% decline in HIV/AIDS deaths from 1995 to 1997 occurred at the same time that more effective antiretroviral therapies became widely available. The slowing in the mortality decline observed in 1998, however, suggests that although these new therapies may have a profound effect at the population level, deaths due to AIDS will continue.
On macroevolution, extinctions and critical phenomena

A new model of large-scale evolution is presented. It involves a simple ecosystem formed by N species related among them through some connections. Random extinction and diversification are involved and it is shown that power-laws in the extinction patterns are obtained, as well as I/f-noise dynamics. Some implications for both theoretical studies and paleobiological data are discussed.
The Dual Functions of IL-1 Receptor-Associated Kinase 2 in TLR9-Mediated IFN and Proinflammatory Cytokine Production

Bone marrow-derived plasmacytoid dendritic cells (pDCs) from IL-1R–associated kinase (IRAK)2-deficient mice produced more IFNs than did wild-type pDCs upon stimulation with the TLR9 ligand CpG. Furthermore, in CpG-stimulated IRAK2-deficient pDCs there was increased nuclear translocation of IFN regulatory factor 7, the key transcription factor for IFN gene transcription in these cells. In IRAK2-deficient macrophages, enhanced NF-κB activation and increased expression of CpG-induced genes were detected within 2 h after treatment. However, at later times, NF-κB activation was decreased and, in contrast to the results with IFN, there was less secretion of other proinflammatory cytokines (such as TNF-α) and chemokines in CpG-stimulated IRAK2-deficient pDCs and macrophages. Therefore, although IRAK2 is a negative regulator of TLR9-mediated IFN production through its modulation of the transcriptional activity of IFN regulatory factor 7, it is also a positive regulator of TLR9-mediated proinflammatory cytokine and chemokine production at some level subsequent to transcription.
Non-linear Gaussian sovereign CDS pricing models

Prior literature indicates that quadratic models and the Black–Karasinski model are very promising for CDS pricing. This paper extends these models and the Black [J. Finance 1995, 50, 1371–1376] model for pricing sovereign CDS’s. For all 10 sovereigns in the sample quadratic models best fit CDS spreads in-sample, and a four factor quadratic model can account for the joint effects on CDS spreads of default risk, default loss risk and liquidity risk with no restriction to factors correlation. Liquidity risk appears to affect sovereign CDS spreads. However, quadratic models tend to over-fit some CDS maturities at the expense of other maturities, while the BK model is particularly immune from this tendency. The Black model seems preferable because its out-of-sample performance in the time series dimension is the best.
Increased bone mineral density in postmenopausal women with type 2 diabetes mellitus

BACKGROUND AND OBJECTIVES Studies of bone mineral density (BMD) in women with type 2 diabetes mellitus have shown conflicting results. We conducted this study to determine whether postmenopausal women with diabetes have higher BMD than non-diabetic women of similar age, and to investigate the relationship between BMD and relevant clinical characteristics in these groups of women. PATIENTS AND METHODS We retrospectively analyzed lumbar spine, femoral neck, and radius BMD data and other relevant clinical data for 130 postmenopausal women with type 2 diabetes mellitus and 166 non-diabetic women collected during a voluntary screening for osteoporosis in postmenopausal women without a history of low bone mass or osteoporotic fractures. RESULTS Women with type 2 diabetes mellitus had significantly higher mean lumbar spine BMD ( 0.903±0.165 vs. 0.824±0.199, respectively, P<.001) and mean femoral neck BMD (0.870±0.132 vs. 0.832±0.134, respectively, P<.05) than non-diabetic women. In both groups of women, age correlated negatively with BMD levels at all three anatomical sites. Higher body mass index was associated only with higher lumbar spine BMD in both groups. Alkaline phosphatase levels showed a negative correlation with BMD at all sites in women with type 2 diabetes mellitus. CONCLUSION Postmenopausal women with type 2 diabetes mellitus have higher BMD levels than non-diabetic women with similar clinical characteristics, and require a more scrutinized approach in managing low bone mass.
Risk of enteric illness associated with travel: a case review of gastroenteritis among Canadian travellers: January to April, 2000.

Risk of Enteric Illness Associated with Travel: A Case Review of Gastroenteritis Among Canadian Travellers: January to April, 2000 . 45 Outbreak of Ebola Hemorrhagic Fever, Uganda, August 2000 – January 2001 . 49 Notifiable Diseases Summary . 54 Announcement . 56 Contenu du présent numéro :
Trade Openness and Carbon Emissions: Evidence from Central and Eastern Europe

Using a composite trade share measure of trade openness, we examined the effects of trade openness on carbon dioxide emission for a sample of 17 Central and Eastern European (CEE) countries over the period 1994 to 2014. We found that high trade openness is associated with low carbon emission in the long run. When compared with the simple measure of trade openness (i.e. total trade as a percentage of GDP), the composite measure indicates that the effect of openness on carbon emission in the long run is smaller in absolute terms. Moreover, while high openness is associated with high emission in the short run using the simple measure, this association is non-existent when using the composite measure. These findings are robust to two historically closed economies and the recent Global Financial Crisis. When testing the Environmental Kuznets Curve (EKC) hypothesis using the composite measure, we found evidence in support of this in the long run. This finding connotes that high openness is associated with low emission in the long run, but up to a certain level of openness. That is, there is a turning point for openness beyond which further openness may spur high emission. Overall, our findings clearly suggest, to a large extent, that the measure of trade openness matters.
Assessment of an Oral Mycobacterium bovis BCG Vaccine and an Inactivated M. bovis Preparation for Wild Boar in Terms of Adverse Reactions, Vaccine Strain Survival, and Uptake by Nontarget Species

ABSTRACT Wildlife vaccination is increasingly being considered as an option for tuberculosis control. We combined data from laboratory trials and an ongoing field trial to assess the risk of an oral Mycobacterium bovis BCG vaccine and a prototype heat-inactivated Mycobacterium bovis preparation for Eurasian wild boar (Sus scrofa). We studied adverse reactions, BCG survival, BCG excretion, and bait uptake by nontarget species. No adverse reactions were observed after administration of BCG (n = 27) or inactivated M. bovis (n = 21). BCG was not found at necropsy (175 to 300 days postvaccination [n = 27]). No BCG excretion was detected in fecal samples (n = 162) or in urine or nasal, oral, or fecal swab samples at 258 days postvaccination (n = 29). In the field, we found no evidence of loss of BCG viability in baits collected after 36 h (temperature range, 11°C to 41°C). Camera trapping showed that wild boar (39%) and birds (56%) were the most frequent visitors to bait stations (selective feeders). Wild boar activity patterns were nocturnal, while diurnal activities were recorded for all bird species. We found large proportions of chewed capsules (29%) (likely ingestion of the vaccine) and lost baits (39%) (presumably consumed), and the proportion of chewed capsules showed a positive correlation with the presence of wild boar. Both results suggest proper bait consumption (68%). These results indicate that BCG vaccination in wild boar is safe and that, while bait consumption by other species is possible, this can be minimized by using selective cages and strict timing of bait deployment.
Educational Aspirations Of Adolescents In Relation To Their Level Of Intelligence

The present study was undertaken with the purpose of studying educational aspiration of adolescents in relation to their intelligence. This study was conducted on a sample of 200 adolescents studying in secondary schools of Amritsar District. The results indicate that gender and type of school do not influence educational aspiration of adolescents, but different levels of intelligence influence the educational aspiration of the adolescents.
Modulated Elliptical Slot Antenna for Electric Field Mapping and Microwave Imaging

Microwave and millimeter wave imaging has shown significant potential in various applications. An imaging system commonly consists of a sensitive electric field mapping array devised to measure the spatial distribution of the scattered field from an object to be imaged. One of the most prominent methods used to realize a cost-effective real-time imaging system is the modulated scatterer technique (MST). Although the conventional MST, using small loaded dipole antennas, performs well at lower microwave frequencies, its utility at high microwave and millimeter wave frequencies is limited. To improve upon the conventional MST, a novel modulated elliptical slot antenna, loaded with a PIN diode, is introduced and analyzed in this paper. The modulation-depth (effectiveness in modulating the slot), current distribution around the slot, and the influence of PIN diode bias structure are discussed based on numerical simulation results and experiments. Finally, the efficacy of the proposed slot for electric field measurements at 24 GHz is demonstrated using a prototype slot.
Oral health status and treatment needs of Iruligas at Ramanagara District, Karnataka, India.

OBJECTIVES To assess the oral health status and treatment needs of Iruliga tribal community residing at Ramanagara District, Karnataka, India. METHODS The total population of 2605 Iruligas residing at 26 villages of Ramanagara District was included for the study. Data were collected using World Health Organization (WHO) 1997 'Oral Health Assessment Form'. Examination was done under good natural light using a mouth mirror and community periodontal index (CPI) probe. RESULTS The total study population was 2605, comprising 1545 males and 1060 females in the age group of 1-80 years with the mean age of 30.56 +/- 19.51. The majority of Iruligas (79.8%) used chew sticks as an oral hygiene aid. Subjects with leukoplakia were found to be 3 (0.12). The most commonly seen enamel opacity/hypoplasia was diffuse opacity affecting 930 (35.7%) subjects. A mild form of dental fluorosis affected 1658 (63.65%) subjects. Subjects with bleeding were only 4.22%; subjects with calculus were 57.9%; those with shallow pockets (4-5 mm) were 22.0% and subjects with deep pockets (> or = 6 mm) were 3.67%. The prevalence of dental caries among Iruligas was found to be 7.52%. The mean number of decayed, missing, filled (DMF) permanent teeth per person was 0.55 +/- 0.1. Definite malocclusion, which required elective treatment, was noted in 14.1%. Iruligas with need for referral were found to be 29.94% (n = 780) according to the various treatment needs required for different oral diseases. CONCLUSION This study revealed less prevalence of oral diseases among Iruligas, highlighting the role of good oral health practices prevalent among this isolated population.
Another Day Another Dollar Metric? An Event History Analysis of Student Loan Repayment

Students increasingly borrow money to attend postsecondary education. Yet, little attention in the literature has been paid to the repayment of student loans, aside from failure indicators like default. This study examines a nationally representative sample of bachelor's degree recipients and the time it takes to reach different repayment thresholds on federal student loans. Motivated by a new federal emphasis on student loan repayment rates, we use event history analysis to show that bachelor's degree recipients have little trouble paying down $1 of their principal balance upon entering repayment. After just six months, 65 percent of this student borrower population had already done so, often paying back much more than $1. However, borrowers enrolled in federal Income-Driven Repayment (IDR) plans took much longer to pay down any loan balance, and many never did in the time we observed their repayment. The consistently negative relationship we find between IDR and paying down loan balances highlights a tension between repayment rate policies and the push for IDR reform of the U.S. repayment system. We discuss the policy implications of these findings and offer an alternative repayment metric to accommodate the contrasting goals and structures of standard repayment schedules versus income-contingent repayment policies.
Effects of Coloured Lighting on the Perception of Interior Spaces

Use of coloured lighting in interior spaces has become prevalent in recent years. Considerable importance is ascribed to coloured lighting in interior and lighting design. The effects of colour on the perception of interior spaces have been studied as surface colour; but here, the effects of three different types of chromatic light were investigated. The lighting differed in colour (red, green and white) and perceptions of interior space were assessed. 97 participants (59 women, 38 men; M age = 21.4 yr.) evaluated the experiment room on a questionnaire assessing eight evaluative factors: Pleasantness, Arousal, Aesthetics, Usefulness, Comfort, Spaciousness, Colour, and Lighting quality. Perceptions of the room differed by colour of lighting for some of the evaluative factors, but there was no sex difference in perceptions. Interior spaces may be perceived as equally pleasant under white, green and red lighting. Under white lighting a space is perceived as more useful, spacious, clear, and luminous. Green lighting would make the same effect. Green and white lighting were perceived equally comfortable in an interior space. Chromatic coloured lighting was perceived to be more aesthetic than white lighting. The results support previous findings for some evaluative factors, but differed for others.
Segmentation of Renal Perfusion Signals From Laser Speckle Imaging Into Clusters With Phase Synchronized Dynamics

Renal perfusion signals contain dynamics arising from the renal autoregulation feedback mechanisms as the contraction and dilation of vessels alter flow patterns. We can capture the time-varying dynamics at points across the renal surface using laser speckle imaging. We segment an imaged area of the renal cortex into clusters with phase synchronized dynamics. Our approach first uses phase coherence with a surrogate data derived threshold to identify synchronized pixel pairs. Non-negative matrix factorization is then applied to segment phase coherence estimates into phase synchronized regions. The method is applied to laser speckle imaging of the renal cortex of anaesthetized rats to identify regions on the renal surface with phase synchronized myogenic activity. In three out of six animals imaged after bolus infusion of Nω-nitro-l-arginine methyl ester (NAM), the renal surfaces are segmented into clusters with high phase coherence. No more than two clusters were identified during control period for any animal. In the remaining three animals, a strong myogenic signal could not be detected in surface perfusion during control or NAM. This method can be used to identify synchronization in renal autoregulation dynamics across the renal surface.
The profession of public relations In Saudi Arabia: a socio-cultural perspective

This thesis examines public relations in Saudi Arabia as an occupational group. The thesis investigates the knowledge public relations practitioners possess, and how Saudi culture and public communication factors affect public relations practitioners. The thesis offers insights into the cultural background of the country, public communication and public relations practice in Saudi Arabia. Moreover, it provides an analysis of theories of the profession and the relationship between the profession and public relations occupation. For the purposes of this research, in-depth unstructured interviews were used to collect data from 27 practitioners. A constructivist paradigm was utilised to examine the Saudi practitioners’ perceptions of knowledge, culture, public communication. Moreover, the thesis has followed a socio-cultural approach and theories of the profession to investigate the empirical data. The thesis has several contributions to knowledge. Firstly, it brings an understanding of the role of the state in the process of professionalization. Using Vygotsky’s theories the thesis has found that educational institutions influence PR practice and this results in lack of progress and limited opportunities for change, learning and career movement. Secondly, the thesis found that there is disconnection between theories that are taught in universities with PR programmes and PR practices. The thesis found that there is a problematic nature of abstract knowledge, which determines the disconnection between communication theories and PR practice. Moreover, there is a disconnection between the practice immersed in culture and that cultural practices are stronger than professional practice. Finally, the thesis has contributed to the literature by finding out that ethics in Western countries are regarded as something that is developed by a professional body in a way that relates to society, however in Saudi Arabia the Muslim values and ethics are implemented directly in the work context and ethics is not developed by a professional body.
Detection of Perchlorate and the Soluble Chemistry of Martian Soil at the Phoenix Lander Site

Phoenix Ascending The Phoenix mission landed on Mars in March 2008 with the goal of studying the ice-rich soil of the planet's northern arctic region. Phoenix included a robotic arm, with a camera attached to it, with the capacity to excavate through the soil to the ice layer beneath it, scoop up soil and water ice samples, and deliver them to a combination of other instruments—including a wet chemistry lab and a high-temperature oven combined with a mass spectrometer—for chemical and geological analysis. Using this setup, Smith et al. (p. 58) found a layer of ice at depths of 5 to 15 centimeters, Boynton et al. (p. 61) found evidence for the presence of calcium carbonate in the soil, and Hecht et al. (p. 64) found that most of the soluble chlorine at the surface is in the form of perchlorate. Together these results suggest that the soil at the Phoenix landing site must have suffered alteration through the action of liquid water in geologically the recent past. The analysis revealed an alkaline environment, in contrast to that found by the Mars Exploration Rovers, indicating that many different environments have existed on Mars. Phoenix also carried a lidar, an instrument that sends laser light upward into the atmosphere and detects the light scattered back by clouds and dust. An analysis of the data by Whiteway et al. (p. 68) showed that clouds of ice crystals that precipitated back to the surface formed on a daily basis, providing a mechanism to place ice at the surface. Most of the chlorine at the Phoenix landing site is in the form of perchlorate, a salt that is highly soluble in water. The Wet Chemistry Laboratory on the Phoenix Mars Lander performed aqueous chemical analyses of martian soil from the polygon-patterned northern plains of the Vastitas Borealis. The solutions contained ~10 mM of dissolved salts with 0.4 to 0.6% perchlorate (ClO4) by mass leached from each sample. The remaining anions included small concentrations of chloride, bicarbonate, and possibly sulfate. Cations were dominated by Mg2+ and Na+, with small contributions from K+ and Ca2+. A moderately alkaline pH of 7.7 ± 0.5 was measured, consistent with a carbonate-buffered solution. Samples analyzed from the surface and the excavated boundary of the ~5-centimeter-deep ice table showed no significant difference in soluble chemistry.