Miracle-dz/UniFAR-FTUs huggingface dataset:
Pediatric Liver Transplantation

Orthotopic liver transplantation (OLT) is a remarkable innovation of the last decade that allows survival in the majority of children with diseases that previously would have been fatal. ' The approximately 100 centers in the United States performing OLT provide approximately 350 children per year with this therapy, with the large majority being treated in a dozen centers. Survival rates in children at the beginning of the 1980s approximated 30%; now, several centers report survival rates as high as 85 to 90%. Our goal is to review OLT as it applies to the pediatric patient. We will provide an overview of indications and contraindications for OLT in children, an approach to evaluating pediatric candidates and managing them before surgery, a highlight of surgical approaches that have had their greatest impact in pediatrics, and some postoperative considerations that have particular relevance to the pediatric recipient.
Trajectory generation of biped robots using Linear Pendulum Mode with virtual supporting point

The trajectory generation methods of biped robots using Linear Pendulum Mode(LPM) with Virtual Supporting Point(VSP) are proposed. LPM is the method that a biped robot is approximated by a pendulum hanged from the ceiling. VSP is the concept that virtually maneuvers the supporting point of a pendulum model. Manipulating the supporting point using VSP, the COG trajectories of LPM of two motions are generated in this paper. One is the motion of double support phase for the landing earlier than planned. Biped robots often land earlier than arranged. At the time, the robots don't achieve the desired condition. It causes the unstable walking to the robots. The trajectory of double support phase is generated considering for the different condition from the plan. Another is the stop motion. Biped robots are able to smoothly stop with the COG velocity and acceleration of 0. The stop time and the stop position of COG are specified. The availability of proposed methods is confirmed by simulations and experiments.
Understanding of human movements in crank rotation

Deals with a crank rotation task. The task requires coordinated movements of arm links without developing excessive internal forces. This research is directed, mainly, to the understanding of comfortable human movements constrained by the external environment. To get a deeper insight into the crank rotation task, we develop a mathematical model and analyze a weighted minimum norm muscle force distribution scheme that can be used in the resolution of the force redundancy. Analysis of experimental data shows that in comfortable motions a human is likely to modulate the rotational stiffness of the crank. This gives an additional constraint that can be used in the resolution of the force redundancy by optimization techniques.
Molecular Genetic Testing of Hemostasis and Thrombosis in Developing Countries: Achievements, Hopes, and Challenges

In today's developing world, how do we define a "developing country"? What level of effort and resources is invested in diagnosis, patient care, and research in those countries that we define to be developing? In particular, what is the situation with respect to molecular genetic testing in these countries? How much has been achieved to date, and what are the challenges to further achievements? This article describes the current status, challenges, and future hopes with respect to molecular genetic testing in hemostasis and thrombosis from the perspective of experts from three countries: Brazil, Colombia, and Iran. These individuals have lived and practiced genetic testing in their countries and have also had the experience to work and/or interact with the developed world to enable an appreciation of the difference.
Improving multifrontal solvers by means of algebraic Block Low-Rank representations. (Amélioration des solveurs multifrontaux à l'aide de représentations algébriques rang-faible par blocs)

We consider the solution of large sparse linear systems by means of direct factorization based on a multifrontal approach. Although numerically robust and easy to use (it only needs algebraic information: the input matrix A and a right-hand side b, even if it can also digest preprocessing strategies based on geometric information), direct factorization methods are computationally intensive both in terms of memory and operations, which limits their scope on very large problems (matrices with up to few hundred millions of equations). This work focuses on exploiting low-rank approximations on multifrontal based direct methods to reduce both the memory footprints and the operation count, in sequential and distributed-memory environments, on a wide class of problems. We first survey the low-rank formats which have been previously developed to efficiently represent dense matrices and have been widely used to design fast solutions of partial differential equations, integral equations and eigenvalue problems. These formats are hierarchical (H and Hierarchically Semiseparable matrices are the most common ones) and have been (both theoretically and practically) shown to substantially decrease the memory and operation requirements for linear algebra computations. However, they impose many structural constraints which can limit their scope and efficiency, especially in the context of general purpose multifrontal solvers. We propose a flat format called Block Low-Rank (BLR) based on a natural blocking of the matrices and explain why it provides all the flexibility needed by a general purpose multifrontal solver in terms of numerical pivoting for stability and parallelism. We compare BLR format with other formats and show that BLR does not compromise much the memory and operation improvements achieved through low-rank approximations. A stability study shows that the approximations are well controlled by an explicit numerical parameter called low-rank threshold, which is critical in order to solve the sparse linear system accurately. Details on how Block Low-Rank factorizations can be efficiently implemented within multifrontal solvers are then given. We propose several Block Low-Rank factorization algorithms which allow for different types of gains. The proposed algorithms have been implemented within the MUMPS (MUltifrontal Massively Parallel Solver) solver. We first report experiments on standard partial differential equations based problems to analyse the main features of our BLR algorithms and to show the potential and flexibility of the approach; a comparison with a Hierarchically SemiSeparable code is also given. Then, Block Low-Rank formats are experimented on large (up to a hundred millions of unknowns) and various problems coming from several industrial applications. We finally illustrate the use of our approach as a preconditioning method for the Conjugate Gradient.
Silicon exposure and vasculitis.

A combination of risk factors are involved in susceptibility to a primary or secondary form of vasculitis. Most forms of vasculitis are probably genetically based but environmentally triggered. This review discusses currently available evidence for a pathophysiologic role of one possible environmental trigger, silica. Since 1960, several patients with pulmonary silicosis have been described that developed pauci-immune necrotizing crescentic glomerulonephritis, i.e., with either completely negative immunofluorescence findings or nonspecific granular IgM or C3 deposits along the capillary wall. Recently it was reported that these patients have antineutrophil cytoplasmic antibodies (ANCAs) that are in most cases directed to myeloperoxidase. Further, patients with pulmonary silicosis may develop microscopic polyangiitis, the syndrome of lung hemorrhage and nephritis, or Wegener's granulomatosis. To further substantiate the relation between silicon exposure and renal failure or vasculitis, several case-control studies have been reported. Exposure to silicon-containing compounds was found to be related to chronic renal failure (odds ratio, 1.7:2.5) or vasculitis (odds ratio, 6.5:14.0). The mechanisms by which silica may induce ANCA-associated glomerulonephritis or vasculitis are not well known. Silicon-containing compounds have a pronounced adjuvant effect on immune responses, and silica particles are potent stimulators of lymphocytes and monocytes or macrophages. Further, silica may induce apoptosis of monocytes or macrophages and possibly neutrophils. In conclusion, at present there is ample evidence that occupational exposure to silicon-containing compounds is related to the development of ANCA-associated glomerulonephritis and vasculitis, and silica is one of the first well-documented environmental triggers in these diseases.
Genetic and phenotypic statistics of lactation cell counts in different lactations of Holstein cows.

Between February 1977 and February 1982, 680,246 monthly test-day observations of somatic cell count were taken for Holstein cows having completed 79,124 lactations in 941 herds on the Quebec Dairy Herd Analysis Service. Data were transformed to natural log scale, and analyses were separate within five parity groups. Two lactational measures of cell count, geometric mean, and weighted (by test-day milk yield) mean of the log of monthly cell counts were calculated for each lactation. Maximum likelihood, iterative Minimum Norm Quadratic Unbiased Estimation, and multivariate Restricted Maximum Likelihood procedures were used for estimation of genetic and phenotypic parameters. Repeatabilities of log test-day cell counts and log of test-day cell counts corrected for milk yield were the same at each parity, . 36, . 41, . 42, . 42, and . 42 in first, second, third, fourth, and fifth and later parities. Repeatabilities of lactational measures of cell count were . 33 between first and second parities, . 40 between second and third parities, . 13 between first and third parities, and . 27 between first, second, and third parities. Heritabilities of measures of lactational cell count were small from . 06 to . 14 in the five parities. Genetic correlations between measures of lactational cell count in different parities were close to unity, . 90 to . 97.
Robust transformation mixed‐effects models for longitudinal continuous proportional data

The authors propose a robust transformation linear mixed‐effects model for longitudinal continuous proportional data when some of the subjects exhibit outlying trajectories over time. It becomes troublesome when including or excluding such subjects in the data analysis results in different statistical conclusions. To robustify the longitudinal analysis using the mixed‐effects model, they utilize the multivariate t distribution for random effects or/and error terms. Estimation and inference in the proposed model are established and illustrated by a real data example from an ophthalmology study. Simulation studies show a substantial robustness gain by the proposed model in comparison to the mixed‐effects model based on Aitchison's logit‐normal approach. As a result, the data analysis benefits from the robustness of making consistent conclusions in the presence of influential outliers. The Canadian Journal of Statistics © 2009 Statistical Society of Canada
Infantile colic: child and family three years later.

OBJECTIVE To assess differences in family functioning or child-rearing attitudes within families with previously colicky infants and to assess whether the children differed in their behavior, development, or frequency of allergies. STUDY DESIGN A controlled, prospective study with infants (3 months to 3 years of age) and their families. PARTICIPANTS Three hundred thirty-eight infants with and 866 infants without exhibited colic and their families. METHODS Questionnaires to mothers and nurses regarding infantile colic (3 months of age); questionnaires to mothers, fathers, and nurses regarding interactions within the family, parents' satisfaction with daily life, child caring, child behavior, and development (3 years old); the Denver Developmental Screening Test (parents filled out at home during the whole 3 years of infant development); the Achenbach Behavior Checklist for 2- to 3-year-old children (the 3-year visit at a well baby clinic). RESULTS The families of previously colicky infants demonstrated more dissatisfaction with the arrangements of daily family responsibilities and with the amount of both leisure time and shared activities. The children in the colic group had more sleeping problems and more frequent temper tantrums (at 3 years of age) than the control group. CONCLUSIONS The families with colicky infants had more distress 3 years later. Families with colicky infants should be provided practical support in improving daily family functioning and child rearing. In addition, underlying problems in family relationships should be managed appropriately.
Do adult-children dialogical interactions leave space for a full development of argumentation? A case study

This paper sets out to analyse a case study of adult-children interaction in an educational context from a perspective of argumentation. We select a case in which 3 argumentative discussions are opened and we analyse them with the aim of understanding whether they are fully developed from a point of view of argumentation; or whether they are cut short and why. Our focus is not on the children’s individual productions but on the process of interaction. We assume the pragma-dialectical model of argumentation and the AMT as a theoretical framework. Our findings show that none of the discussions opened gets to a concluding stage, either because the teacher shifts the discussion on a different issue, or because the opening stage is not clear, or because the argumentation stage is not adequately developed. These findings contribute to conceptual clarification about how to interpret the role of a teacher.
Experimental Study of LY333328 (Oritavancin), Alone and in Combination, in Therapy of Cephalosporin-Resistant Pneumococcal Meningitis

ABSTRACT Using a rabbit model of meningitis, we sought to determine the efficacy of LY333328, a semisynthetic glycopeptide, in the treatment of cephalosporin-resistant pneumococcal meningitis. LY333328 was administered at a dose of 10 mg/kg of body weight/day, alone and in combination with ceftriaxone at 100 mg/kg/day with or without dexamethasone at 0.25 mg/kg/day. The therapeutic groups were treated with LY333328 with or without dexamethasone and LY333328-ceftriaxone with or without dexamethasone. Rabbits were inoculated with a cephalosporin-resistant pneumococcal strain (ceftriaxone MIC, 2 μg/ml; penicillin MIC, 4 μg/ml; LY333328 MIC, 0.008 μg/ml) and were treated over a 26-h period beginning 18 h after inoculation. The bacterial counts in cerebrospinal fluid (CSF), the white blood cell count, the lactic acid concentration, the CSF LY333328 concentration, and bactericidal and bacteriostatic activities were determined at different time points. In vitro, LY333328 was highly bactericidal and its use in combination with ceftriaxone at one-half the MIC was synergistic. In the rabbit model, LY333328 alone was an excellent treatment for cephalosporin-resistant pneumococcal meningitis, with a rapid decrease in colony counts and no therapeutic failures. The use of LY333328 in combination with ceftriaxone improved the activity of LY333328, but no synergistic effect was observed. The combination of LY333328 with dexamethasone was also rapidly bactericidal, but two therapeutic failures were observed. The combination of LY333328 with ceftriaxone and dexamethasone was effective, without therapeutic failures.
Testing Web applications

The rapid diffusion of Internet and open standard technologies is producing a significant growth of the demand of Web sites and Web applications with more and more strict requirements of usability, reliability, interoperability and security. While several methodological and technological proposals for developing Web applications are coining both from industry and academia, there is a general lack of methods and tools to carry out the key processes that significantly impact the quality of a Web application (WA), such as the validation & verification (V&V), and quality assurance. Some open issues in the field of Web application testing are addressed in this paper. The paper exploits an object-oriented model of a WA as a test model, and proposes a definition of the unit level for testing the WA. Based on this model, a method to test the single units of a WA and for the integration testing is proposed. Moreover, in order to experiment with the proposed technique and strategy, an integrated platform of tools comprising a Web application analyzer, a repository, a test case generator and a test case executor, has been developed and is presented in the paper. A case study, carried out with the aim of assessing the effectiveness of the proposed method and tools, produced interesting and encouraging results.
Revenue Sharing Contract of Supply Chain with Fuzzy Linear Demand

In a two-stage supply chain composed of a supplier and a retailer, the supply chain models in fuzzy linear demand environment are researched. The parameters of market linear demand function are regarded as trapezoidal fuzzy numbers. The decision processes are analyzed under the decentralized and centralized decision, and the decision model with revenue sharing contract mechanism is also built by the method of fuzzy cut sets theory with fuzzy linear demand. It is shown that in fuzzy linear demand environment, the double marginalization effect is still existed in supply chain system; the profits of members can be coordinated by revenue sharing contract. Finally, a numerical is given to illustrate the model and the solution process.
Consequences of bovine oocyte maturation, fertilization or early embryo development in vitro versus in vivo: Implications for blastocyst yield and blastocyst quality

The aim of this study is to examine the effect of bovine oocyte maturation, fertilization or culture in vivo or in vitro on the proportion of oocytes reaching the blastocyst stage, and on blastocyst quality as measured by survival following vitrification. In Experiment 1, 4 groups of oocytes were used: (1) immature oocytes from 2–6 mm follicles; (2) immature oocytes from > 6 mm follicles; (3) immature oocytes recovered in vivo just before the LH surge; and (4) in vivo matured oocytes. Significantly more blastocysts developed from oocytes matured in vivo than those recovered just before the LH surge or than oocytes from 2–6 mm follicles. Results from > 6 mm follicles were intermediate. All blastocysts had low survival following vitrification. In Experiment 2, in vivo matured oocytes were either (1) fertilized in vitro or (2) fertilized in vivo by artificial insemination and the resulting presumptive zygotes recovered on day 1. Both groups were then cultured in vitro. In vivo fertilized oocytes had a significantly higher blastocyst yield than those fertilized in vitro. Blastocyst quality was similar between the groups. Both groups had low survival following vitrification. In Experiment 3a, presumptive zygotes produced by in vitro maturation (IVM)/fertilization (IVF) were cultured either in vitro in synthetic oviduct fluid, or in vivo in the ewe oviduct. In Experiment 3b, in vivo matured/in vivo fertilized zygotes were either surgically recovered on day 1 and cultured in vitro in synthetic oviduct fluid, or were nonsurgically recovered on day 7. There was no difference in blastocyst yields between groups of zygotes originating from the same source (in vivo or in vitro fertilization) irrespective of whether culture took place in vivo or in vitro. However, there was a dramatic effect on blastocyst quality with those blastocysts produced following in vivo culture surviving vitrification at significantly higher rates than their in vitro cultured counterparts. Collectively, these results indicate that the intrinsic quality of the oocyte is the main factor affecting blastocyst yields, while the conditions of embryo culture have a crucial role in determining blastocyst quality. Mol. Reprod. Dev. 61: 234–248, 2002. © 2002 Wiley‐Liss, Inc.
Schwann cells and cells in the oligodendrocyte lineage proliferate in response to a 50,000 dalton membrane‐associated mitogen present in developing brain

The neuronal cell surface is believed to carry a mitogenic signal for peripheral glial cells. We have purified a mitogen from fetal bovine brain membranes that, in common with the PNS neuronal mitogen, stimulates the proliferation of Schwann cells in vitro and binds heparin. The purified mitogen has an apparent molecular weight of 50,000 daltons as estimated by elution of activity from non‐reducing polyacrylamide gels. Since the developing central nervous system is a rich source of mitogen, we tested whether the protein is mitogenic for one or more cell types isolated from the developing brain. Purified mitogen was added to enriched cultures of astrocytes or developing oligodendrocytes, or to microglial cells. The analyses demonstrated that the protein is mitogenic for developing oligodendrocytes but not astrocytes or microglial cells. These results suggest that during development a membrane‐associated mitogen present in the brain might regulate the proliferation of developing oligodendrocytes, and consequently, the population size of oligodendrocytes in the brain.
How “Intuition” Exploded

Recent decades have seen a surge in interest in metaphilosophy. In particular there has been an interest in philosophical methodology. Various questions have been asked about philosophical methods. Are our methods any good? Can we improve upon them? Prior to such evaluative and ameliorative concerns, however, is the matter of what methods philosophers actually use. Worryingly, our understanding of philosophical methodology is impoverished in various respects. This article considers one particular respect in which we seem to be missing an important part of the picture. While it is a received wisdom that the word “intuition” has exploded across analytic philosophy in recent decades, the article presents evidence that the explosion is apparent across a broad swathe of academia (and perhaps beyond). It notes various implications for current methodological debates about the role of intuitions in philosophy.
No evidence for association of the CD40, CD40L and BLYS polymorphisms, B-cell co-stimulatory molecules, with Brazilian endemic Plasmodium vivax malaria.

BACKGROUND Plasmodium vivax is the most prevalent malaria species in Brazil. The parasite-host coevolutionary process can be viewed as an 'arms race', in which adaptive genetic changes in one are eventually matched by alterations in the other. METHODS Following the candidate gene approach we analyzed the CD40, CD40L and BLYS genes that participate in B-cell co-stimulation, for associations with P. vivax malaria. The study sample included 97 patients and 103 controls. We extracted DNA using the extraction and purification commercial kit and identified the following SNPs: -1C > T in the CD40 gene, -726T > C in the CD40L gene and the -871C > T in the BLyS gene using PCR-RFLP. We analyzed the genotype and allele frequencies by direct counting. We also compared the observed with the expected genotype frequencies using the Hardy-Weinberg equilibrium. RESULTS The allele and genotype frequencies for these SNPs did not differ statistically between patient and control groups. Gene-gene interactions were not observed between the CD40 and BLYS and between the CD40L and BLYS genes. Overall, the genes were in Hardy-Weinberg equilibrium. Significant differences were not observed among the frequencies of antibody responses against P. vivax sporozoite and erythrocytic antigens and the CD40 and BLYS genotypes. CONCLUSIONS The results of this study show that, although the investigated CD40, CD40L and BLYS alleles differ functionally, this variation does not alter the functionality of the molecules in a way that would interfere in susceptibility to the disease. The variants of these genes may influence the clinical course rather than simply increase or decrease susceptibility.