Miracle-dz/UniFAR-FTUs huggingface dataset:
Histopathological Study of Colorectal Carcinomas

1 Associate Professor of Pathology, Mysore Medical College and Research Institute Mysore Address: # 574/A, North East of N R Mohalla, Mysore 570007 Email: karrashilpa@yahoo.com, Contact number: 9060500075 2 Postgraduate student, Mysore Medical College and Research Institute, Mysore Email: monicags737@gmail.com, Contact number: 9916222939 Abstract: Introduction: Colorectal carcinoma ranks the fourth most frequent cancers in men and third in women which causes significant mortality and morbidity. Studies have shown increasing trend in incidence in India. Chronic inflammatory bowel diseases like ulcerative colitis, crohn’s disease and schistosoma mansoni infection, high calorie diet and sedentary life style are etiological factors for colorectal carcinoma. Pathological examination of the biopsy and resected specimens is important for appropriate patient management, prognosis assessment and family counselling. Aims and Objectives: This is a retrospectively conducted study at our institute to evaluate histopathologically the colorectal carcinomas based on age and sex distribution. Material and Methods: All cases of abdominoperineal resection, colectomy, rectal and colonic biopsy received in the Department of Pathology, Mysore Medical College and Research Institute over a period of 3 years (between july 2013 – july 2016) were evaluated. Results: The study included 75 cases with almost equal prevalence in males and females, with most of the cases occurring in 6 th decade and adenocarcinoma not otherwise specified is the most common malignancy and rectum being the commonest site. Conclusion: Colorectal adenocarcinoma is a heterogenous disease that involves multiple tumorigenic pathways. Prediction of prognosis in colorectal cancer is vital for the choice of therapeutic options. Histopathologic diagnosis remain paramount importance in this aspect.
Chlamydia trachomatis infection and the risk of perinatal 29 ( 2001 ) 55 2 59 mortality in Hungary

Introduction: Chlamydial infections of the genital tract are thought to often lead to preterm birth, which is the most important perinatal problem in Hungary. Aim of study: A multicenter study was carried out to determine the prevalence of Chlamydia trachomatis infection, risk factors for the infection and to relate the infection to perinatal mortality, accounting for potential confounding effects. Methods: The nucleic acid hybridization method (PACE2 Gen-Probe) was applied for the examination of J. Perinat. Med. 29 (2001) In summary, testing pregnant women for diseases that can be transmitted perinatally is an important part of obstetric care. Screening for C. trachomatis is suggested only in high-risk pregnancies such as those involving an unfavorable obstetric history, a poor socio-economic situation and a young age less than 24 years old. Any attempt to prevent the spread of STDs must include the provision of contraceptives, sex education, efforts to arouse a more responsible attitude to pregnancy, and attempts to improve the social environment [1]. Chlamydia trachomatis. Logistic regression analysis was used to assess risk. Results: A total of 6156 pregnant women were examined for the occurrence of Chlamydia trachomatis. The observed overall rate of chlamydial infection was 5.9 %. Young age (less than 24 years old) (OR and 95 % CI:1.6 (1.322.0)), unmarried status (1.5 (1.221.9)) and the high unemployment rate (2.1 (1.622.7)) were statistically significant predictors of the infection. Nyári et al, Chlamydia trachomatis infection and the risk of perinatal mortality 59 In logistic regression analysis, chlamydial infection (1.9 (1.123.3)), high unemployment rate (1.5 (1.222.2)) and low birth weight (1.7 (1.122.7) were significant predictors of perinatal mortality.
Referring to Cinderella in L2 Japanese: A preliminary study

This study reports how English-speaking learners of intermediate Japanese refer to the subject noun referents previously introduced within a given discourse. Tsuchiya, Yoshimura & Nakayama (2015) and Nakayama, Yoshimura & Tsuchiya (2015) report that English-speaking L2 Japanese learners only rarely used kanojo ‘she’ during their telling of the story of The Little Match Girl. Instead, we observed a frequent use of null pronouns as well as a positive correlation between language proficiency and a repetitive use of referential nouns. The use of null pronouns, but not kanojo, may come from an instructional effect as those learners were taught the null pronominal use earlier than kanojo. The current study analyzing the Cinderella story in L2 Japanese also finds a more frequent use of null pronouns than referential nouns and kanojo, which may indicate the importance of explicit instruction and more exposure to narratives in the target language.
How Much and How Quick? Pass through of Commodity and Input Cost Changes to Retail Food Prices

Following the food, energy, and overall commodity price surge from mid 2007 to mid 2008, both domestic and international retail food prices rose at an accelerated rate for most of 2008. These changes sparked a renewed interest in both food policy and food industry arenas in estimates of the magnitude of the effect of commodity price changes on retail food prices. The subsequent drop in commodity prices during the fourth quarter of 2008 and beginning of 2009 led to the same set of questions in the opposite direction. What impact do volatile swings in commodity prices have on retail food prices? This paper uses Bureau of Labor Statistics (BLS) price index data across various stages of food production along with data on energy and wage costs to estimate: how much of the change in commodity costs is generally passed through to retail prices; how the pass-through rate varies by food type; and just as important, the time lag between commodity price changes and retail price changes across a number of food groups. A number of factors combined to lead to the run-up in commodity prices in 2007 and 2008. Trostle (2008) divides these factors into supply and demand effects and shows that tight market conditions were the impetus for the sharp increase in food commodity prices. More rapid expansion in demand and slower growth in production began in the 1990s and contributed to declining global demand for reserve stocks of grains beginning in the early 2000s. Then, rising oil prices and evolving biofuel policies provided incentives to expand biofuel production in some countries. In addition
Assessing the Implementation of Fieldwork in the Teaching of Geography in Some Senior Secondary Schools in Kano, Nigeria

Geographical field work has been argued to be particularly useful in the development of insight, attainment of cognitive/intellectual, technical achievements and development of empathy in students. In view of this argument therefore geographical field work becomes an inalienable and corporate part of teaching and learning process in schools. The study therefore assesses the implementation of fieldwork in some senior secondary schools in Kano state. Stratified random sampling was used to select 10 schools out of the 34 public senior secondary in the metropolitan area. Teachers‟ and students formed the sampling frame for the study. All the geography teachers in the selected schools were use as samples since their number is not large. This way a total of 37 geography teachers were selected for the study. Stratified random sampling was employed to select 50 students from six schools out of the ten sampled schools. Data was gotten through the participant observation and administration of questionnaire to the samples. The students were pre tested on some selected concepts in physical geography before going to the field. The pre and the post fieldwork tests were analysed using mean, standard deviation and analysis of variance. The result show significant difference in the mean scores of students for the pre and post test scores. The study found among other things, that the field work was better in enhancing students understanding of geographical concepts and appreciation of the natural environment; it was also found that the involvement of students in group work was seen as a step in the development of leadership roles amongst them. Some of the major constraints to the effective implementation of field work in schools are attributed to inadequate preparation on the parts of the teachers, large classes, time constraint and inadequate funding insecurity amongst others.
Metalloproteinases and neurodegenerative diseases: pathophysiological and therapeutic perspectives

License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress. com/permissions.php Metalloproteinases In Medicine 2015:2 39–50 Metalloproteinases In Medicine Dovepress
NEURAL NETWORKS AND AGENT-BASED DIFFUSION MODELS

This paper introduces a new consumer decision-making model where each agent uses a neural network to evaluate word-of-mouth and predict her utility prior to adoption a new product based on her experiences in the past. The model considers the fact that consumers may not know their true preferences before experiencing the product. By using a neural network, an agent can: (1) interpret the feedback from a neighbor who has conflicting preferences with her; (2) interpret partially positive and/or negative feedback; and, (3) assign different weights to the feedback received from different neighbors. The model is implemented in an agent-based simulation model to verify that the resulting diffusion dynamics follow a typical diffusion curve. Preliminary experiments with the model also provide interesting results about the effect of the number of product attributes on the quality of an individual’s utility prediction as well as proportion of satisfied adopters.
Diagnosing the context of inter-organizational systems by mapping key-players

Inter-organizational systems (IOS) are generally used in a context of various interested parties. If these parties are not identified and if their power and interests related to the IOS are not explored and taken into consideration, implementation is likely to become a disappointing and troublesome affair. This paper presents a diagnostic method for the identification of stakeholders involved in IOS and the assessment of their power and interests with respect to these systems. The diagnostic approach is illustrated by means of an in-depth case study. The case study indicates that addressing power and interest relationships may help make the critical success factors in the implementation and improvement of inter-organizational systems more explicit. On the basis of the case study, conclusions are drawn regarding the application and usefulness of the diagnostic approach.
Far tail or extreme day returns, mutual fund cash flows and investment behaviour

This study examines the frequency of extreme trading days and investment behaviour in Sweden. We show that the frequency, as well as the magnitude of extreme trading days has increased over time. We also show that the frequency of extreme trading days in a year is positively correlated to the frequency the preceding year and that this behaviour has persisted from 1940 to 2006. Furthermore, we show that aggregate cash flows into equity and bond funds are unrelated to risk measured by SD of return. Our findings show that investors, individuals as well as corporations, use simple passive investment strategies and hence do not believe in market timing or wish to risk capital on capturing far tail or black swan-type returns.
Invasion potential of H 22 hepatocarcinoma cells is increased by HMGB 1-induced tumor NF-κ B signaling via initiation of HSP 70

The functional relationship and cross-regulation between damage-associated molecular patterns and NF-κB in the tumor microenvironment remains unclear. In the present study, high-mobility group protein B1 (HMGB1) was secreted in response to feed second phase of NF-κB activation from heat shock protein (HSP) 70 that may result in a higher invasion potential of hepatocarcinoma cells. HSP70 promoted the proliferation of H22 hepatocarcinoma cells through Toll-like receptor (TLR) 2 and TLR4 signaling and induced the early phosphorylation of NF-κB, which reached maximum levels within 30 min. However, HSP70 promoted the upregulation of Beclin-1 expression via Jun N-terminal kinase (JNK) activation in tumor cells and the release of HMGB1 from tumor cells. Inhibition of Beclin-1/c-JNK production prevented the second, but not the first, phase of NF-κB phosphorylation, implicating Beclin-1/c-JNK in the second phase of phosphorylation. HSP70 induced Beclin-1-derived HMGB1 production at 4 h, which occurred before the rise in the second phosphorylation that occurred at 6 h. Exogenous HMGB1 also induced the rapid phosphorylation of NF-κB and upregulated the expression of MMP-9, inhibited the rapid phosphorylation of NF-κB and reduced MMP-9 by receptor for advanced glycation end products (RAGE) inhibitor that prevented HMGB1-induced cell invasion in vitro, which demonstrated that the biological significance of HMGB1/RAGE is key to the second, but not the first, phase of NF-κB phosphorylation in tumor cells. HSP70 triggered a positive feedback loop of NF-κB activation in H22 cells. The second phase of NF-κB phosphorylation mediated by HSP70 is implicated in the increase of tumor cell malignant invasion.
1 E 1-mediated recruitment of a UAF 1-USP deubiquitinase complex 2 facilitates human papillomavirus DNA replication 3 4

E1-mediated recruitment of a UAF1-USP deubiquitinase complex 2 facilitates human papillomavirus DNA replication 3 4 Michaël Lehoux, David Gagnon and Jacques Archambault* 5 6 Institut de Recherches Cliniques de Montréal (IRCM), 110 Pine Avenue West, Montreal, 7 Quebec, Canada, H2W 1R7 and Department of Biochemistry and Molecular Medicine, 8 Université de Montréal, Montreal, Quebec, Canada 9 10 11 These authors contributed equally to this work. 12 13 Abstract: 245 words 14 Text: 6459 words 15 16 Running Title: Recruitment of a UAF1-USP complex by HPV E1 17 18 19 * Corresponding author: Laboratory of Molecular Virology, Institut de Recherches 20 Cliniques de Montréal (IRCM), 110 Pine Avenue West, Montreal, Quebec, Canada, H2W 21 1R7, Tel (514) 987-5739; Fax (514) 987-5741; E-mail: jacques.archambault@ircm.qc. ca 22 23 JVI Accepts, published online ahead of print on 21 May 2014 J. Virol. doi:10.1128/JVI.00379-14 Copyright © 2014, American Society for Microbiology. All Rights Reserved.
Compression therapies for chronic venous leg ulcers: interventions and adherence

Compression therapy has been the mainstay for the treatment of lower extremity edema, venous insufficiency, and particularly, venous ulcerative disease. Though modern surgical treatments exist, none are completely effective without good compressive options to allow for decreased swelling and better oxygenation of damaged tissues. This review article will describe the pathophysiology and presentation of lower extremity venous ulcerations, as well as current options for compression therapy. The benefits, along with the major pitfall of nonadherence, will also be discussed.
Source Properties of Earthquakes near the Salton Sea Triggered by the 16 October 1999 M 7.1 Hector Mine, California, Earthquake

We analyze the source properties of a sequence of triggered earthquakes that occurred near the Salton Sea in southern California in the immediate aftermath of the M 7.1 Hector Mine earthquake of 16 October 1999. The sequence produced a number of early events that were not initially located by the regional network, including two moderate earthquakes: the first within 30 sec of the P-wave arrival and a second approximately 10 minutes after the mainshock. We use available amplitude and waveform data from these events to estimate magnitudes to be approximately 4.7 and 4.4, respectively, and to obtain crude estimates of their locations. The sequence of small events following the initial M 4.7 earthquake is clustered and suggestive of a local aftershock sequence. Using both broadband TriNet data and analog data from the Southern California Seismic Network (SCSN), we also investigate the spectral characteristics of the M 4.4 event and other triggered earthquakes using empirical Green's function (EGF) analysis. We find that the source spectra of the events are consistent with expectations for tectonic (brittle shear failure) earthquakes, and infer stress drop values of 0.1 to 6 MPa for six M 2.1 to M 4.4 events. The estimated stress drop values are within the range observed for tectonic earthquakes elsewhere. They are relatively low compared to typically observed stress drop values, which is consistent with expectations for faulting in an extensional, high heat flow regime. The results therefore suggest that, at least in this case, triggered earthquakes are associated with a brittle shear failure mechanism. This further suggests that triggered earthquakes may tend to occur in geothermal–volcanic regions because shear failure occurs at, and can be triggered by, relatively low stresses in extensional regimes.
Cardioprotective Effect of Erythropoietin on Isoprenaline Induced Myocardial Infarction in Rats

Background: Erythropoietin (Epo) has been shown to have important cytoprotective properties against ischemic damage of the myocardium besides its important hematopoietic effect. Aim: This study was designed to find out the possible effects of treatment with recombinant human erythropoietin in rat model of myocardial infarction induced by isoproterenol (Isoprenaline). Materials and Methods: Adult male albino rats weighing 200 – 220 gm were divided into 4 groups: group I (Control group): Received no medications and given free access to food and water. Group II (ISO group): Injected intraperitoneal "i.p." with a single dose of isoprotrenol in a dose of 75 mg/kg body weight for induction of myocardial infarction. Group III (ISO + rhEPO): Injected i.p. by single dose recombinant human EPO (rhEPO) in a dose of 5000 I.U/kg body weight, 2 hours after induction of myocardial infarction with isoprotrenol. Group IV (rhEPO 10 days + ISO): Injected i.p. with rhEPO in a dose of 5000 I.U/kg body weight/day for 10 days before induction of myocardial infarction with isoproterenol. Results: A significant reduction in the infarction size, serum cardiac enzymes (CPK and LDH), significant increases in plasma NO and nonsignificant change in both mean systemic arterial blood pressure (MSABP) and hematocrit (Hct) value were observed in rats injected with a single dose of rhEPO (5000 I.U/ kg body weight), 2 hours after induction of myocardial infarction when compared with rat model of myocardial infarction (ISO group). Pretreatment of rats with rhEPO (5000 I.U/ kg body weight/day) for 10 days before induction of myocardial infarction causes significant decrease in cardiac enzymes and infarction size, non-significant change in plasma NO, significant increase in Hct value and MSABP when compared with rat model of myocardial infarction. While on comparing these results with those rats treated with single dose of rhEPO, 2 hours after induction of myocardial infarction, there was significant decrease in cardiac enzyme, plasma NO, Significant increase in MSABP, Hct value and nonsignificant change in the infarction size. Conclusion: Cardioprotective effect conferred by rhEPO has many mechanisms. One of them is by modulating the hemodynamic functions through increasing the plasma NO concentration. Although, treatment with rhEPO for longer periods may result in increased hematocrit associated side effects such as hypertension or thromboembolism.
DEMENTIA WITH LEWY BODIES RELATIVE TO ALZHEIMER ’ S DISEASE AND PARKINSON ’ S DISEASE WITH DEMENTIA

The cognitive profiles of patients with dementia with Lewy bodies (DLB) and Parkinson’s disease with dementia (PD-D) are quite similar, though different from Alzheimer’s disease. However, studies comparing the memory performance of patients with DLB, PD-D and AD are rare. Patients with DLB, AD and PD-D – matched for general cognitive status – were compared on a range of memory measures. Semantic memory, verbal fluency and verbal learning were assessed. Delayed verbal recall was better preserved in DLB and PD-D than AD. Semantic memory was better preserved in PD-D than AD. Neither letter nor category fluency differentiated between the groups. Our study shows the usefulness of the Auditory Verbal Learning Test (AVLT) as an easily administered verbal learning measure for further research assessing episodic memory in DLB in comparison to PD-D and AD.
Real-Time Vehicle Roll Angle Estimation Based on Neural Networks in IoT Low-Cost Devices

The high rate of vehicle-crash victims has a fatal economic and social impact in today’s societies. In particular, road crashes where heavy vehicles are involved cause more severe damage because they are prone to rollover. For this reason, many researches are focused on developing RSC Roll Stability Control (RSC) systems. Concerning the design of RSC systems with an adequate performance, it is mandatory to know the dynamics of the vehicle. The main problem arises from the lack of ability to directly capture several required dynamic vehicle variables, such as roll angle, from low-cost sensors. Previous studies demonstrate that low-cost sensors can provide data in real-time with the required precision and reliability. Even more, other research works indicate that neural networks are efficient mechanisms to estimate roll angle. Nevertheless, it is necessary to assess that the fusion of data coming from low-cost devices and estimations provided by neural networks can fulfill hard real-time processing constraints, achieving high level of accuracy during circulation of a vehicle in real situations. In order to address this issue, this study has two main goals: (1) Design and develop an IoT based architecture, integrating ANN in low cost kits with different hardware architectures in order to estimate under real-time constraints the vehicle roll angle. This architecture is able to work under high dynamic conditions, by following specific best practices and considerations during its design; (2) assess that the IoT architecture deployed in low-cost experimental kits achieve the hard real-time performance constraints estimating the roll angle with the required calculation accuracy. To fulfil these objectives, an experimental environment was set up, composed of a van with two set of low-cost kits, one including a Raspberry Pi 3 Model Band the other having an Intel Edison System on Chip linked to a SparkFun 9 Degrees of Freedom module. This experimental environment be tested in different maneuvers for comparison purposes. Neural networks embedded in low-cost sensor kits provide roll angle estimations highly approximated to real values. Even more, Intel Edison and Raspberry Pi 3 Model B have enough computing capabilities to successfully run roll angle estimation based on neural networks to determine rollover risk situations, fulfilling real-time operation restrictions stated for this problem.