Miracle-dz/UniFAR-FTUs huggingface dataset:
Early Administration of Tirofibanin Mid- to High-risk Patients with Non-ST Elevation Acute Coronary Syndrome Referred for Elective Percutaneous Coronary Intervention (ETN-STEP): A Multi-center Randomized Controlled Clinical Trial in China

Aims: The objective of this randomized controlled clinical trial was to evaluate the efficacy and safety of upstream administration of Tirofiban in mid- to high-risk patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS) undergoing early percutaneous coronary intervention (PCI). Methods and results: A total of 478 patients with mid- to highrisk NSTE-ACS were randomized into two groups: 220 patients in the upstream group who received tirofiban 12 hours before PCI, and 258 patients in the downstream group who received tirofiban after angiography. Use of tirofiban lasted till 24-36 hours after PCI in both groups. Coronary blood flow and myocardial perfusion were evaluated as primary endpoints. Major adverse cardiovascular events (MACEs) and bleeding events were evaluated as secondary endpoints. Results: Results showed that the percentage of TIMI myocardial perfusion grade 3 after PCI was significantly higher (93.8% vs 87.2%, P=0.02) and the corrected TIMI frame count was significantly lower (16.0 vs 18.0, P=0.002) in the upstream group compared with the downstream group.
Working Papers on Innovation and Space

This paper examines regional effects of the InnoRegio program, which was conducted by the German Federal Ministry of Education and Research. The InnoRegio program has been a new tool of innovation policy with the aim to improve innovativeness in East Germany on the basis of prosperous regional networks. Besides the direct support of networks and innovation activities, the program was meant to trigger the regional development in East Germany. While existing studies examine whether the development of networks or cluster was successful, this paper focuses on the investigation of regional economic development. Using regional data, especially on employment and patents, we examine whether the involved industries have developed better in supported regions than in other (East) German regions. Developments are investigated for a time span including years before, during and after the policy measure. We find some positive effects in the regional development that can be assigned to the InnoRegio program.
Salicylic Acid Accumulation Causes Alteration in Abscisic Acid Signaling and Induces Abscisic Acid Insensitivity in the Lesion Mimic Mutant cpr22

Some Arabidopsis lesion mimic mutants (LMM) show alterations in abiotic stress responses as well as pathogen resistance. cpr22 is a LMM which has a mutation in cyclic nucleotide-gated ion channels, is a typical LMM exhibiting elevated levels of salicylic acid (SA), spontaneous cell death, constitutive expression of defense genes, and enhanced resistance to various pathogens in an SA dependant manner. cpr22 defense responses are suppressed in high humidity and enhanced by low humidity. To investigate environmental effects, microarray analyses were conducted. Expression of several genes related to abscisic acid (ABA) signaling was altered and ABA levels increased in cpr22 after humidity shift. Furthermore, significant alterations in ABA-related phenotypes were observed. Double mutant analysis with nahG plants indicated that alterations in ABA signaling were attributable to elevated SA levels. These results suggest a negative effect of SA on ABA signaling/abiotic stress responses during the activation of defense responses.
Epidemiology of Infective Endocarditis

Infective endocarditis is a rare disease, with an incidence of two to six episodes per 100,000 habitants/year. Incidence is higher in elderly people; besides, this group is often affected by many comorbidities. There is a clear and observable change in the spectrum of heart diseases predisposing to infective endocarditis in the last decades. Up to one-third of the patients acquire the disease on a health-care-associated environment. Despite advances in health-care logistics, infective endocarditis remains a big concern especially in low-income countries, where the main cause of infection is rheumatic fever. In-hospital mortality persists relatively high despite development in medical and surgical treatment. Patients with infective endocarditis need rapid response and prompt diagnosis from a multidisciplinary group including cardiologists, surgeons, infectolo-gists, and radiologists.
Identifying Vulnerable Displaced Workers: The Role of State-Level Occupation Conditions

Some displaced workers experience larger earnings changes after displacement than others. Using comprehensive occupational employment data, I estimate the effect of the state-level occupation growth rate in the worker’s pre-displacement occupation on subsequent labor market outcomes. I find that adverse labor market conditions in a worker’s occupation at the time of displacement have negative consequences. Displacement from a shrinking occupation is associated with decreased earnings and longer durations of joblessness. Furthermore, holding the occupation growth rate constant, there is only a small effect of the worker’s industry growth rate on their labor market outcomes. These results suggest that vulnerable displaced workers’ difficulties in the labor market are a function of their skills and less related to the goods and services they were previously producing. (JEL: J24,
Phylogeography of Seychelles' endemic skink genera Pamelaescincus and Janetaescincus

Unveiling patterns of genetic differentiation across insular distributions is relevant for biogeographic and conservation reasons. In the Indian Ocean, surprisingly, little is known regarding the genetic structure of many taxa across the Seychelles Islands, despite their importance as old Gondwanic islands, part of the Western Indian Ocean biodiversity hotspot. In recent molecular studies, a northeastern-southwestern subdivision pattern across the granitic islands has been uncovered within some species. Pamelaescincus gardineri, a Seychelles endemic skink and possibly one of the deepest lineages of Afro-Malagasy “scincines”, is another species widespread across these islands within which undescribed variation may occur. Both nuclear (c-mos and MC1R) and mitochondrial (Cyt-b) DNA data were used to address this issue. Mitochondrial DNA shows a marked FCUP Phylogeography of Seychelles’ endemic skink genera Pamelaescincus and Janetaescincus ! 12! northeastern-southwestern structure of two highly divergent clades, similar to the pattern previously described in other reptile species. Nuclear DNA seems to corroborate this pattern, although these markers were much less informative. Migration between the two island groups was identified, and gene flow between the two mtDNA lineages is likely, the extent of which remains to be fully explored. This will require more variable nuclear markers and more detailed sampling across the island of Mahé. A suitable assessment of morphological variation is also needed prior to any taxonomic revision of this species. From a conservation point of view, however, these lineages should already be treated as two distinct evolutionary units.
Evaluating Accuracy and Precisión in Morphologic Traits for Sexual Dimorphism in Malnutrition Human Skull: a Comparative Study

Uno de los propositos mas importantes del protocolo antropologico de estudios de osamentas humanas, es la determinacion del sexo. Algunos craneos pueden ser clasificados erroneamente debido a condiciones sistemicas presentadas durante la vida de individuos que hayan afectado a las fuerzas musculares que actuan sobre el hueso, como es el caso de la desnutricion severa. El proposito de este estudio fue determinar la exactitud y confiabilidad, sobre los parametros morfologicos determinantes de dimorfismo sexual, clasicamente estudiados en el analisis visual del craneo, para los dos grupos que componen la muestra, uno con desnutricion acompanando el momento del deceso y otro con causa de muerte sin ese factor acompanante. Se utilizaron 163 craneos humanos de sexo, edad y causa de muerte conocido, pertenecientes a la coleccion de la UNIFESP. Se realizaron la inspeccion visual del craneo y el diagnostico de sexo en base a: tamano y arquitectura general del craneo, aspecto del hueso cigomatico, tamano y rugosidades del proceso mastoides, rugosidades del hueso occipital y aspecto general de la mandibula. Los craneos fueron clasificados en dos grupos, de acuerdo a si presentaron desnutricion severa descrita en su causa de muerte (n=60) o presentaban otra causa de muerte (n=103). Los resultados de la inspeccion se compararon con la del registro para determinar la exactitud en el diagnostico y la sensibilidad del metodo para hombres y mujeres, en los dos grupos analizados. En el grupo con desnutricion, el mejor indicador resulto el aspecto del hueso cigomatico, con un 86,6% de exactitud. En el otro grupo, la mayor exactitud se encontro en el tamano del proceso mastoides (87,3%). En ambos grupos, los mayores valores de sensibilidad fueron para hombres (83,3-95,3%). La sensibilidad para mujeres presento menores valores en el grupo sin desnutricion (69,2-76,9%) que en el grupo con desnutricion (72,4-89,65%), estas diferencias resultaron estadisticamente significativas (p<0,05).
Simultaneous v. sequential lineups: What do we really know?

Both conceptual and metaanalyses of the effects of simultaneous and sequential lineup testing procedures on false alarm and hit rates suggest that recent interest in moving to sequential lineups might be premature. A simple criterion-shift model based on signal detection analysis accounted for the results from the metaanalysis raising concern that the previously accepted relative v. absolute decision strategy view may be incorrect. The accepted view that hit rates will be unaffected by a change in procedure may be incorrect. Monte Carlo simulation results raise the possibility that serial position might play a much larger and more complicated role in performance on sequential lineups than has been considered. Much more research is needed before the sequential procedure is adopted.
Asthma and Injury Risk: A Large Scale Population-Based Study

Purpose: Clinical data suggest that asthma impairs sleep quality and further impairs cognitive performance during the daytime, while there is a causal relationship between impaired sleep quality and injuries. Therefore asthma patients may have increased risk of injury, and this is supported by our recent population-based studies conducted in Australia. This study is to investigate the effect of asthma on the risk of injury at the population level using data from the U.S. National Health Interview Survey collected in 2008, 2009, and 2010. Method: Data from the 2008, 2009 and 2010 National Health Interview Surveys were combined and analyzed together. Results: U.S. adults with current or previous asthma had significantly greater risk of injury compared to those without asthma. The risk of injury was also significantly higher among children with current asthma. Conclusion: This population-based study provided further evidence on the positive association between asthma and risk of injury among both adults and children. The increased risk of injury among asthma patients is at least partly due to impaired sleep quality and quantity caused by asthma symptoms and asthma medications.
Quantification of bioactive compounds in crem (Tropaeolum pentaphyllum Lam) tubers: fibers, phenolic compounds and evaluation of its antioxidant activity

Crem (Tropaeolum pentaphyllum Lam) is a tuber that is well-known in the south of Brazil, particularly in the states of Santa Catarina and Rio Grande do Sul. It is used as a condiment in food and is normally prepared by being grated and pickled in red vinegar. This study aimed to chemically characterize crem and to quantify its bioactive compounds. The following were evaluated: chemical composition; phenolic compounds by the Folin-Ciocalteu method; antioxidant capacity by scavenging of the 2,2-diphenyl-1-picryl hydrazyl (DPPH) radical; and flavonoids by high-performance liquid chromatography (HPLC). The results indicated that the tuber was a good source of fiber (16.79%); the values found for total phenolic compounds were 32.98 ± 0.57 mg GAE/100 g and DPPH free radical scavenging activity was 22.49 ± 0.74%. In the quantification of phenolic compounds the following five flavonoids were identified: kaempferol (15.62 ± 0.01 mg/g); luteolin (12.17 ± 0.03 mg/g); quercetin (10.45 ± 0.01 mg/g) coumarin (6.38 ± 0.02 mg/g) and rutin (0.84 ± 0.01 mg/g). Other components found in crem were caffeic acid (6.15 ± 0.02 mg/g), gallic acid (4.97 ± 0.03 mg/g) and chlorogenic acid (4.73 ± 0.01 mg/g). The crem has good fiber supply, but presents low amount of phenolic compounds and antioxidant activity when compared to other condiments. Some flavonoids stand out in relation to other condiments, making it a culinary alternative.
Solar-wind control of plasma sheet dynamics

Abstract. The purpose of this study is to quantify how solar-wind conditions affect the energy and plasma transport in the geomagnetic tail and its large-scale configuration. To identify the role of various effects, the magnetospheric data were sorted according to different solar-wind plasma and interplanetary magnetic field (IMF) parameters: speed, dynamic pressure, IMF north–south component, epsilon parameter, Auroral Electrojet (AE) index and IMF ultra low-frequency (ULF) fluctuation power. We study variations in the average flow speed pattern and the occurrence rate of fast flow bursts in the magnetotail during different solar-wind conditions using magnetospheric data from five Time History of Events and Macroscale Interactions during Substorms (THEMIS) mission spacecraft and solar-wind data from NASA's OMNIWeb. The time interval covers the years from 2008 to 2011 during the deep solar minimum between cycles 23 and 24 and the relatively quiet rising phase of cycle 24. Hence, we investigate magnetospheric processes and solar-wind–magnetospheric coupling during a relatively quiet state of the magnetosphere. We show that the occurrence rate of the fast (|Vtail| > 100 km s−1) sunward flows varies under different solar-wind conditions more than the occurrence of the fast tailward flows. The occurrence frequency of the fast tailward flows does not change much with the solar-wind conditions. We also note that the sign of the IMF BZ has the most visible effect on the occurrence rate and pattern of the fast sunward flows. High-speed flow bursts are more common during the slow than fast solar-wind conditions.
Radiology image perception and observer performance: How does expertise and clinical information alter interpretation? Stroke detection explored through eye-tracking

Historically, radiology research has been dominated by chest and breast screening. Few studies have examined complex interpretative tasks such as the reading of multidimensional brain CT or MRI scans. Additionally, no studies at the time of writing have explored the interpretation of stroke images; from novices through to experienced practitioners using eye movement analysis. Finally, there appears a lack of evidence on the clinical effects of radiology reports and their influence on image appraisal and clinical diagnosis. A computer-based, eye-tracking study was designed to assess diagnostic accuracy and interpretation in stroke CT and MR imagery. Eight predetermined clinical cases, five images per case, were presented to participants (novices, trainee, and radiologists; n=8). The presence or absence of abnormalities was rated on a five-point Likert scale and their locations reported. Half cases of the cases were accompanied by clinical information; half were not, to assess the impact of information on observer performance. Results highlight differences in visual search patterns amongst novice, trainee and expert observers; the most marked differences occurred between novice readers and experts. Experts spent more time in challenging areas of interest (AOI) than novices and trainee, and were more confident unless a lesion was large and obvious. The time to first AOI fixation differed by size, shape and clarity of lesion. 'Time to lesion' dropped significantly when recognition appeared to occur between slices. The influence of clinical information was minimal.
Treatment with Lithium Induces a Long-Term Enhancement of Neurogenesis in the Subventricular Zone of the Ts65Dn model of Down Syndrome

One of the major challenges of research on Down syndrome (DS) is the identification of treatments that are able to improve intellectual disability, the invariable hallmark of this genetic condition. The DS brain is characterized by a severe impairment of neurogenesis that starts at prenatal life stages and continues throughout life [1,2]. This defect largely accounts for the typical hypotrophy of the DS brain and, hence, intellectual disability. It ensues that means to improve/restore neurogenesis can be regarded as potential tools to improve intellectual disability in DS. The bulk of neurons forming the forebrain derive from the fetal ventricular zone (VZ) and, subsequently, from the subventricular zone (SVZ) of the lateral ventricle. The subgranular zone (SGZ) of the hippocampal dentate gyrus is a neurogenic niche that is specifically responsible for hippocampal neurogenesis. The SVZ and the SGZ retain proliferative capacity throughout life in all examined mammals [3]. In particular, the adult SVZ produces granule neurons destined to the olfactory bulb and the SGZ produces granule neurons destined to the granular layer of the dentate gyrus. In view of the key role of the SVZ in the generation of forebrain neurons, it appears to be particularly relevant to identify treatments that are able to increase neurogenesis in this neurogenic niche because they might be exploited in order to restore cortical neurogenesis during the most critical phases of brain development.
Spatially varying constraints of human-caused fire occurrence in British Columbia, Canada

Human-caused wildfires are controlled by human and natural influences, and determining their key drivers is critical for understanding spatial patterns of wildfire and implementing effective fire management. We examined an array of explanatory variables that account for spatial controls of human-caused fire occurrence from 1990 to 2013 among six ecosystem zones that vary in human footprint and environmental characteristics in British Columbia, Canada. We found that long-term patterns of human-caused fire in ecosystem zones with a larger human footprint were strongly controlled by biophysical variables explaining conditions conducive to burning, whereas fire occurrence in remote ecosystem zones was controlled by various metrics of human activity. A metric representing the wildland–urban interface was a key factor explaining human-caused fire occurrence regardless of ecosystem zone. Our results contribute to the growing body of research on the varying constraints of spatial patterns of fire occurrence by explicitly examining human-caused fire and the heterogeneity of constraints based on human development.
DETERMINATION OF THE PHOSPHATE CONTENT ORIGINALLY ADSORBED ON THE SOIL BY FITTING AN ADSORPTION ISOTHERM MODEL

In order to replace the rather complicated physico-chemical method, a mathematical technique related to the binding of phosphate ions was elaborated to determine the labile, and thus plant-available phosphate content of the soil. The technique is based on the analysis of the quantity of phosphate bound to the soil in the equilibrium state when soil samples are suspended in solutions containing various concentrations of phosphate. The majority of soils contain a certain amount of adsorbed phosphate, so negative adsorption is observed if the analysis is carried out with solutions containing little or no phosphate. The isotherm models generally used to describe adsorption processes do not assume the presence of any material originally bound on the adsorbent surface, so their starting point is a state with a zero quantity of adsorbed material on the adsorbent in a solution with an initial equilibrium concentration of zero. In the case of soil phosphate adsorption, however, different results are obtained, as the soil already contains adsorbed phosphate in its original state. For this reason the isotherm model was modified. The modified isotherm model was fitted to the measurement data using non-linear regression. The quantity of phosphate originally adsorbed on the soil can be calculated using a model parameter. The phosphate quantity calculated in this way exhibits a close correlation both with the isotopically exchangeable phosphate content, and with the results obtained with the best chemical extraction methods.
Conditions on Iterative Rounding Harmony in Oroqen

In this paper, we re-examine the claim that Baiyinna Oroqen, a language of the Tungusic family with a largely predictable distribution of non-high round vowels, requires a non-iterative type of rounding harmony, by demonstrating instead the need for a clear distinction between stem-internal morpheme structure constraints and suffixal vowel harmony. We also propose to revise what was thought to be a requirement that harmony donors must be anchored in two successive syllables; it is instead a restriction that copying of the harmonic feature must be from the closest non-initial vowel.
Somatotopic principle of perineural implantation of stem cells in patients with brain injuries

Background: Neuro destructive processes of any etiology are related to problematic and socially important diseases due to ineffective therapeutic strategy and need to search for new successful ways of treatment and rehabilitation of patient with cerebral infarctions and brain attacks Aims: Authors plant overify hypothesis on viability of additional use of perineural implantation of autologous mesenchymal stem cells (MSC) in order to optimize standard therapy of patients with brain attacks. Such combined technology is aim datextra activation of brain plasticity mechanisms during development of neuro destructive processes. Methods: The technique of MSC perineural migration to injured brain regions was experimentally verified on rats (n=40) paying attention to somatotopic organization of cranial nerves. This technique was clinically tested in pilot project. Phenotyping of autologous MSC from adipose tissue (AT) was performed in 23 patients with brain attacks. These 23 patients received standard treatment as per international guidelines together with three perineural implantations of autologous MSC from AT with 5-9days intervals. The other group of patients (n=7) received only standard therapy as per international guidelines. Results: Additional use of cell therapy resulted in more rapid and effective recovery of disordered neurological functions in all cases compared to those who received standard therapy. The phenomenon of abrupt recovery of neurological functions was established during first 24hours after each injection of autologous MSC. Cumulative recovery of functions progressed after each implantation. Discussion and conclusion: Experimentally developed technique of perineural implantation of autologous MSC was successfully verified in clinical conditions in accordance with certified cell therapy guideline (The Ministry of Health of the Republic of Belarus) in combination with standard treatment of patients with cerebral infarctions. Cell therapy with autologous MSC from AT by means of perineural delivery to injured brain regions is the basis for activation of reparative potential of nerve tissue and progressive recovery of neurological functions in patients with cerebral infarctions.