Miracle-dz/UniFAR-FTUs huggingface dataset:
Alveolar adenoma of the lung

Alveolar adenoma is a rare and benign tumour of the lung that usually presents in asymptomatic patients as a coin lesion on chest radiography. Only 25 cases have been reported in the English medical literature. Alveolar adenoma has a characteristic multicystic histology and often resembles the normal lung parenchyma. Ultrastructural studies indicate that the epithelial cells lining the cysts are type‐II pneumocytes. Immunohistochemical analysis may aid in the characterization of alveolar adenoma and discriminate this condition from other types of benign lesions of the lung. An indolent clinical progression and absence of recurrence and metastasis after complete resection are the most important characteristics indicative of the benign nature of alveolar adenoma. Few studies have been conducted at the molecular level, such as by flow cytometry, with the objective of characterizing the biological nature of alveolar adenoma. Differential diagnoses include sclerosing hemangioma, papillary adenoma, lymphangioma, atypical adenomatous hyperplasia and bronchioloalveolar carcinoma. In this article we describe the immunohistochemical and flow cytometric features of this neoplasm in two male patients. Both the tumours showed a diploid DNA pattern with a low proliferation index. p53 test was found to be negative, and post‐operative follow‐up examinations at 22 and 32 months proved uneventful.
Predicting Continuance—Findings From a Longitudinal Study of Older Adults Using an eHealth Newsletter

While eHealth technologies are promisingly efficient and widespread, theoretical frameworks capable of predicting long-term use, termed continuance, are lacking. Attempts to extend prominent information technology (IT) theories to the area of eHealth have been limited by small sample sizes, cross-sectional designs, self-reported as opposed to actual use measures, and a focus on technology adoption rather than continuance. To address these gaps in the literature, this analysis includes empirical evidence of actual use of an eHealth technology over the course of one year. This large (n = 4,570) longitudinal study focuses on older adults, a population with many health needs and among whom eHealth use may be particularly important. With three measurement points over the course of a year, this study examined the effects of utilitarian and hedonic beliefs on the continued use of an eHealth newsletter using constructs from IT adoption and continuance theories. Additional analyses compared the relative strength of intentions compared to earlier use in predicting later use. Usage intention was strongly predicted by both hedonic beliefs and utilitarian beliefs. In addition, utilitarian beliefs had both direct effects on intention and indirect effects, mediated by hedonic beliefs. While intention predicted subsequent use, earlier use was a significantly stronger predictor of use than intention. These findings make a theoretical contribution to an emerging literature by shedding light on the complex interplay of reasoned action and automaticity in the context of eHealth continuance.
Prevalence of cardiovascular risk factors among healthcare staff in a large healthcare institution in Singapore.

INTRODUCTION This study aimed to determine the prevalence of modifiable cardiovascular risk factors among health workers (HWs) and non-health workers (NHWs) in a large hospital in Singapore. METHODS A cross-sectional prevalence survey of 3,384 hospital staff was conducted. The study comprised a self-administered questionnaire, body mass index, systolic and diastolic blood pressure measurements, and laboratory analysis of fasting blood samples of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides and plasma glucose. HWs were doctors and nurses, while NHWs were health administrators, facility staff, clerks and administrative personnel. RESULTS A total of 3,384 out of 3,987 eligible staff (response rate 84.9%) participated in the survey. The majority of the participants were female (81%, n = 2,755), and 64% (n = 2,179) were 20-39 years old. HWs comprised almost two-thirds of the staff employed (61.3%, n = 2076), of whom 87.7% were female, while 72.5% of NHWs were female. Compared to HWs, NHWs had a higher adjusted (age, ethnic group and gender) prevalence of personal history of diabetes mellitus (adjusted prevalence rate ratio [PRR] 1.64, 95% confidence interval [CI] 1.02-2.64), cigarette smoking (adjusted PRR 1.85, 95% CI 1.48-2.32), obesity (adjusted PRR 1.36, 95% CI 1.05-1.75) and elevated systolic pressure (adjusted PRR 1.74, 95% CI 1.31-2.31). CONCLUSION The prevalence of modifiable cardiovascular risk factors in NHWs is higher than that in HWs. Health promotion programmes should address this captive and neglected audience in healthcare organisations.
Study of equatorial E region irregularities using rare daytime VHF scintillation observations

Scintillations on VHF radio signal are sparsely observed during daytime due to unavailability of strong electron density irregularities in equatorial E or F region. Type I/II irregularities observed at E region altitudes during the daytime are linked with either two‐stream or gradient drift instability. The occurrence of these irregularities in presence of strong blanketing Es (Esb) can produce weak‐moderate scintillations on VHF signal during daytime. Such sparse daytime VHF scintillations are used in the present study to retrieve information about E region irregularities, which are generally examined with radar observations. We use spaced receiver scintillation observations on 251 MHz signal transmitted from geostationary satellite UFO2 (71.2°E) and recorded at Tirunelveli (8.5°N, 77.8°E, dip latitude 0.6°N). Ionosonde data from Trivandrum (8.5°N, 76.6°E, dip latitude 0.5°N) during 2003–2005 is used to confirm the association of daytime scintillations with Esb. The daytime scintillations last for 15–45 min during postnoon hours. Their occurrence closely matches the peak occurrence time of Esb. For the first time, spatial scale lengths of E region irregularities are obtained using the technique introduced by Bhattacharyya et al. (2003). The observed spatial scales are validated using theoretical model. The theoretical model manifests 6–19% density fluctuations in the E region to produce weak scintillations (0.15 ≤S4≤ 0.4) on 251 MHz. The study reveals that scale lengths of E region irregularities are smaller on counter equatorial electrojet (CEEJ) days than non‐CEEJ days, which could be resulting from lower electron temperatures in E region on CEEJ days.
Alpha Thalassemia is Associated With Decreased Risk of Abnormal Transcranial Doppler Ultrasonography in Children With Sickle Cell Anemia

Purpose: Cerebrovascular complications of sickle cell disease (SCD) are common, but the risk factors remain unclear. The multicenter Stroke Prevention Trial in Sickle Cell Anemia (STOP) provided an opportunity to examine alpha thalassemia‐2 as a modifying risk factor, using abnormal transcranial Doppler ultrasonography (TCD) as a surrogate marker for cerebrovascular disease. The authors hypothesized that children with abnormal TCD are less likely to have alpha thalassemia‐2, and an increased hemoglobin level accounts for this protective effect. Methods: A retrospective study was conducted of children with SCD who had both alpha gene and TCD data from STOP: 128 with TCD of at least 200 cm/s (abnormal TCD) and 172 with TCD less than 170 cm/s (normal TCD). Results: Alpha thalassemia‐2 was more frequent in the normal TCD group compared with the abnormal TCD group. The odds ratio for normal TCD and alpha thalassemia‐2 was 4.1. Adjusting for either hemoglobin level or red cell size (mean corpuscular volume) reduced the odds ratio only slightly. Age, normal TCD, and alpha thalassemia‐2 had significant statistical interaction, so that alpha thalassemia‐2 was not related to TCD for age 10 years or older. Conclusions: The frequency of alpha thalassemia‐2 was significantly higher in children with normal TCD. Speculation on mechanisms of effect includes improved erythrocyte deformability, reduced red cell adhesion, and reduced nitric oxide scavenging in alpha thalassemia‐2. The association of alpha thalassemia‐2 and normal TCD adds to the evidence on the protective effects of alpha thalassemia‐2 in SCD and highlights the contribution of epistatic factors.
Exploring the interactive patterns of concept map-based online discussion: a sequential analysis of users’ operations, cognitive processing, and knowledge construction

Concept maps can be used as a cognitive tool to assist learners' knowledge construction. However, in a concept map-based online discussion environment, studies that take into consideration learners' manipulative actions of composing concept maps, cognitive process among learners' discussion, and social knowledge construction at the same time are still lacking. Therefore, this study employed lag sequential analysis to empirically explore learners' behavioral patterns in a concept map-based online discussion environment. We explored learners' operations in the concept map tool, and their discussion behavioral patterns of cognitive processing phases and social knowledge construction. The results showed that it was easier for learners to define a node than to define a relationship when they used the concept map. Additionally, the concept map can enhance higher level cognitive processing phases and lead learners to return to the main discussions from off-topic discussions significantly.
Autoantibodies against erythropoietin in a patient with pure red-cell aplasia.

Autoimmunity is often implicated in pure red-cell aplasia. Approximately 10 to 15 percent of patients with pure red-cell aplasia have thymomas,1 and remission of the anemia occurs in 25 to 30 percent of these patients after the thymoma is removed.2 In other patients there are immunologic abnormalities, such as hypogammaglobulinemia,3 monoclonal immunoglobulins,4 antithyroid antibodies,5 antinuclear antibodies,6,7 and autoimmune hemolytic anemia.3,8 Immunosuppressive therapy is successful in many patients,2,9–12 and a good response to plasmapheresis has been reported in two patients.13,14 In 1967 Krantz and Kao reported that plasma from a patient with pure red-cell aplasia inhibited .
Pigmented epithelioid Spitz naevus: report of two cases

and focal and weak reactivity for AE1+3, NSE, CG and NF. Of interest, with immunostaining highlighting the interstitial cells, a vague nodular pattern of mixed carcinoid cells and interstitial cell proliferation was more evident (Figure 1d). The stromal tissue in the metastatic TCT was not immunoreactive for cytokeratin AE1+3, CG, NSE and NF. Of the nine LCTs, one tumour showed diffuse, moderate reactivity for cytokeratin AE1+3 and CG (Figure 2a,b) and NSE, and focal reactivity for SYN and NF. In the remaining eight tumours, the immunoreactivity to these markers was negative to focally mild. The Leydig cells in the tissue surrounding the TCT and LCT showed focal and weak reactivity for cytokeratin AE1+3, CG, NSE, SYN and NF. The primary TCT in this study was characterized by the presence of interstitial cells in the tumour mass. It is unlikely that that such foci represent entrapment of the native Leydig cell population because: (i) the Leydig cells in such foci within the tumour mass appeared to be proliferating with vague nodular formation, (ii) the absence of Leydig cells in secondary TCT suggested that such entrapment is not a usual process in the growth of carcinoid tumour, and (iii) ‘transitional cells’ were present in the primary TCT, displaying features of both Leydig cells and carcinoid tumour cells. In the group of LCTs, one of nine LCTs showed features of NE differentiation, as evidenced by positive reactivity for NE markers, such as CG, NSE and SYN, and cytokeratin. The present data support the notion that the carcinoid tumour cells and the Leydig cells in this primary TCT probably arose from the same progenitor cells. K T Mai P C Park H M Yazdi M Carlier
Nervous Structures with Dynamical Links

Connectivity patterns (instead of mere activity distributions) are argued to be the natural objects of fast brain dynamics. They are to be understood as a basis for self-organization. Natural assumptions on cooperation and competition lead to a conjecture regarding the type of dynamically preferred connectivity patterns. The conjecture is supported and illustrated by dynamic simulation. Applications to sensory segmentation, to invariant pattern recognition, and to resonant projection between homeomorphic structures are discussed.
Right hemisphere lateralization for emotion in the human brain: interactions with cognition

Right-handed subjects tend to look to the left when answering affective questions. The relative shift in gaze from right to left is accentuated when the questions also involve spatial manipulation and attenuated when the questions require verbal manipulation. The data support the hypothesis that the right hemisphere has a special role in emotion in the intact brain, and that predictable patterning of hemispheric activity can occur when specific combinations of cognitive and affective processes interact.
Life Cycle Energy Consumption and Greenhouse Gas Emissions Analysis of Natural Gas-Based Distributed Generation Projects in China

In this paper, we used the life-cycle analysis (LCA) method to evaluate the energy consumption and greenhouse gas (GHG) emissions of natural gas (NG) distributed generation (DG) projects in China. We took the China Resources Snow Breweries (CRSB) NG DG project in Sichuan province of China as a base scenario and compared its life cycle energy consumption and GHG emissions performance against five further scenarios. We found the CRSB DG project (all energy input is NG) can reduce GHG emissions by 22%, but increase energy consumption by 12% relative to the scenario, using coal combined with grid electricity as an energy input. The LCA also indicated that the CRSB project can save 24% of energy and reduce GHG emissions by 48% relative to the all-coal scenario. The studied NG-based DG project presents major GHG emissions reduction advantages over the traditional centralized energy system. Moreover, this reduction of energy consumption and GHG emissions can be expanded if the extra electricity from the DG project can be supplied to the public grid. The action of combining renewable energy into the NG DG system can also strengthen the dual merit of energy conservation and GHG emissions reduction. The marginal CO2 abatement cost of the studied project is about 51 USD/ton CO2 equivalent, which is relatively low. Policymakers are recommended to support NG DG technology development and application in China and globally to boost NG utilization and control GHG emissions.
Spectrophotometric Determination of Chlorophyll - A, B and Total Carotenoid Contents of Some Algae Species Using Different Solvents

In our study, chlorophyll a, chlorophyll b and the total amounts of carotenoids in Cladophora glomerata (L.) Kuetzing, Ulva rigita L. , Codium tomentosum (Huds.) Stackh and Cladostephus verticillatus Ag. species were determined. Methanol, acetone and diethyl ether were used as solvents. The chlorophyll amount in Cladophora glomerata L. Kuetzing, species and carotenoids in Cladostephus verticillatus Ag. were found the highest. It was observed that sonication had no much contribution to the extraction.
Skin wounds in the MRL/MPJ mouse heal with scar

Adult MRL/MpJ mice regenerate cartilage during repair of through‐and‐through ear punch wounds. However, the ability of this mouse strain to heal isolated cutaneous wounds by regeneration or with scar is unknown. The purpose of this study was to characterize the rate of reepithelialization and collagen architecture in dermal wounds from MRL/MpJ mice compared with C57bl/6 and Balb/c strains. Full‐thickness incisional (5 mm) and excisional (2 mm diameter) skin wounds were made on the dorsum of 7‐week‐old MRL/MpJ, C57bl/6, and Balb/c mice. Ear punch wounds were made simultaneously on each animal. Reepithelialization was complete by 48 hours for incisional skin wounds in each strain. All excisional wounds showed incomplete reepithelialization at 24, 48, and 72 hours. At 14 days, all skin wounds had grossly healed. In contrast to the ear wounds made in C57bl/6 and Balb/c mice, MRL/MpJ ear wounds were completely healed by day 28. Dorsal skin wound sections at 14 and 28 days revealed dense collagen deposition and similar degrees of fibrosis between the three strains of mice. In conclusion, in contrast to wound healing in the ear, MRL/MpJ mouse dorsal cutaneous wounds heal similarly to C57bl/6 and Balb/c mice with dermal collagen deposition and scar formation.
Broad-band double-layered coplanar patch antennas with adjustable CPW feeding structure

In this paper, we have presented the double-layered coplanar patch antennas of enhanced impedance bandwidth and adjustable conductor-backed coplanar waveguide feed lines. The proposed structure retains the advantage of laying the coplanar patch and coplanar waveguide (CPW) feed line on the same surface, which makes direct integration with other devices easier. In addition, the substrate thickness of the radiating patch can be adjusted to achieve a wider impedance bandwidth while the dimensions of the CPW feed line are kept unchanged. Simulation has been done by using commercial electromagnetic (EM) simulation software. Four testing antennas, which have centre frequency at about 10 GHz, were designed. The four testing antennas had the same total thickness, but different thickness combinations. From the measured return loss, gain, and radiation patterns of the antennas, it was demonstrated that different thickness combinations do not affect the characteristics of the antennas seriously. Therefore, the dimensions of the CPW feed structure of the antennas can be adjusted individually and can be selected for different applications.
A follow‐up study of postpartum psychoses: prognosis and risk factors for readmission

Terp IM, Engholm G, Møller H, Mortensen PB. A follow‐up study of postpartum psychoses: prognosis and risk factors for readmission. Acta Psychiatr Scand 1999: 100: 40–46. © Munksgaard 1999.
Reacquisition of Specific Proteins Confers Virulence in Mycoplasma pneumoniae

Hemadsorbing revertants were isolated from spontaneous hemadsorption-negative, avirulent mutants of Mycoplasma pneumoniae. The revertants simultaneously reacquired specific proteins absent in their homologous mutants, along with neuraminidase-sensitive adherence to the respiratory epithelium and virulence. Peptide mapping and immunological analysis indicated no precursor-product relationships among certain of these proteins.
Insulin Receptor Substrate 1 and 2 but not Shc can Activate the Insulin Receptor Independent of Insulin and Induce Proliferation in CHOIR Cells

Ligand-activated insulin receptor (IR) attracts and phosphorylates various substrates such as insulin receptor substrates 1-4 (IRS) and Shc. To investigate how binding affinity for substrate affects signalling we generated chimeric receptors with the beta-chain of the insulin receptor containing NPXY motives with different affinities for receptor substrates. We found that the extent of receptor tyrosine phosphorylation positively correlates with binding affinity towards IRS1/2 but not towards Shc. Moreover, overexpression of IRS1 or IRS2 but not of Shc increased IR tyrosine phosphorylation in a dose-dependent manner, also independent of insulin. Molecular truncations of IRS1 revealed that neither the isolated PH and PTB domains nor the C-terminus with the tyrosine phosphorylation sites alone are sufficient for substrate-dependent receptor activation. Overexpression of IRS1 and IRS2 impaired insulin-induced internalization of the IR in a dose-dependent manner suggesting that IRS proteins prevent endosome-associated receptor dephosphorylation/inactivation. IRS1 and IRS2 could therefore target the activated IR to different cellular compartments. Overexpression of IRS1 and IRS2 inhibited insulin-stimulated activation of the MAP kinases Erk1/2 while it increased/induced activation of Akt/PKB. Finally, overexpression of IRS1 and IRS2 but not of Shc induced DNA synthesis in starved CHO-IR cells independent of exogenous growth factors. Our results demonstrate that variations in cellular IRS1 and IRS2 concentration affect insulin signalling both upstream and downstream and that IRS proteins could play instructive rather than just permissive roles in signal transmission. Niessen et al., IRS1 and IRS2 can activate the insulin receptor in CHO-IR cells 1 Insulin Receptor Substrate 1 and 2 but not Shc can Activate the Insulin Receptor Independent of Insulin and Induce Proliferation in CHO-IR Cells Markus Niessen, Frank Jaschinski, Flurin Item, Morgan P. McNamara, Giatgen A. Spinas and Thomas Trüb * authors contributed equally to this work (1) Clinic of Endocrinology and Diabetes, University Hospital Zurich, Ramistrasse 100, 8091 Zurich, Switzerland. (2) Institute of Human Movement Sciences and Sport, ETH Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland (3) Zentrale Dienste der Universität, Ausrüstung und Logistik, Y10 G 22, Winterthurerstrasse 190, 8057 Zurich, Switzerland Correspondence and reprint requests to Markus Niessen, Ph.D., Clinic of Endocrinology and Diabetes, Department of Internal Medicine, University Hospital, CH 8091 Zurich, Switzerland. E-mail: markus.niessen@usz.ch Niessen et al., IRS1 and IRS2 can activate the insulin receptor in CHO-IR cells 2
Dissidents with an innovation cause? Non-institutionalized actors' online social knowledge sharing, solution-finding tensions and technology management innovation

Purpose – Traditionally, most studies focus on institutionalized management-driven actors to understand technology management innovation. The purpose of this paper is to argue that there is a need for research to study the nature and role of dissident non-institutionalized actors’ (i.e. outsourced web designers and rapid application software developers). The authors propose that through online social knowledge sharing, non-institutionalized actors’ solution-finding tensions enable technology management innovation. Design/methodology/approach – A synthesis of the literature and an analysis of the data (21 interviews) provided insights in three areas of solution-finding tensions enabling management innovation. The authors frame the analysis on the peripherally deviant work and the nature of the ways that dissident non-institutionalized actors deviate from their clients (understood as the firm) original contracted objectives. Findings – The findings provide insights into the productive role of solution-finding tensions in enabling opportunities for management service innovation. Furthermore, deviant practices that leverage non-institutionalized actors’ online social knowledge to fulfill customers’ requirements are not interpreted negatively, but as a positive willingness to proactively explore alternative paths. Research limitations/implications – The findings demonstrate the importance of dissident non-institutionalized actors in technology management innovation. However, this work is based on a single country (USA) and additional research is needed to validate and generalize the findings in other cultural and institutional settings. Originality/value – This paper provides new insights into the perceptions of dissident non-institutionalized actors in the practice of IT managerial decision making. The work departs from, but also extends, the previous literature, demonstrating that peripherally deviant work in solution-finding practice creates tensions, enabling management innovation between IT providers and users.