Miracle-dz/UniFAR-FTUs huggingface dataset:
Factors improving the outcome of patients re-irradiated with intensity-modulated radiotherapy (IMRT) for relapse or new head and neck cancer developed in irradiated areas.

BACKGROUND Patients with secondary/recurrent squamous cell head and neck cancer have poor prognoses. Re-irradiation is a treatment option. However, best technique to re-irradiate is not known. This study aims to evaluate the outcome of patients treated with curative-intent intensity-modulated radiotherapy (IMRT) re-irradiation (re-RT) for head and neck (H&N) cancers. METHODS Fifty patients with recurrent H&N cancers underwent fractionated IMRT re-RT. The median time between the two courses of radiotherapy was 22 months. The median dose of re-RT was 66 Gy. RESULTS The median follow-up of surviving patients was 13.6 months. The median overall survival (OS) was 15.7 months, and the 1- and 2-year OS rates were 62.4% and 33.9%, respectively. On multivariate analysis, performance status (PS) 0-1 (HR, 0.518; 95% CI: 0.292-0.917; P=0.024) and 3D-RT use during the first irradiation course technique (HR, 0.415; 95% CI: 0.183-0.938; P=0.035) were favorable, independent of significant prognostic factors of OS. The median loco-regional progression-free survival (LRPFS) was 8.3 months, and, the 1- and 2-year LRPFS rates were 46.6% and 35.9%, respectively. On multivariate analysis, a surgical resection before re-RT (HR, 0.107; 95% CI: 0.027-0.428; P=0.002), a higher age (HR, 0.894; 95% CI: 0.833-0.960; P=0.002), a PS 0-1 (HR, 0.316; 95% CI: 0.140-0.715; P=0.006), and a long re-RT interval (HR, 0.970; 95% CI: 0.945-0.996; P=0.024) were favorable independent significant prognostic factors of LRPFS. The median progression-free survival (PFS) was 7.0 months and, the 1- and 2-year PFS rates were 45.0% and 30.4%, respectively. On multivariate analysis, a surgical resection before re-RT (HR, 0.129; 95% CI: 0.036-0.466; P=0.002), a PS 0-1 (HR, 0.399; 95% CI: 0.208-0.764; P=0.006) and, a long re-RT interval (HR, 0.958; 95% CI: 0.927-0.989; P=0.009) were favorable, independent significant prognostic factors. The early and late toxicities rates were 28% and 34%, respectively. CONCLUSIONS Re-RT for H&N cancers can be curative, and the complications can be manageable but patients need to be strictly selected. Surgery before re-RT could improve the patient outcome. Dose and irradiation schedules should be prospectively evaluated.
IEST: WASSA-2018 Implicit Emotions Shared Task

Past shared tasks on emotions use data with both overt expressions of emotions (I am so happy to see you! ) as well as subtle expressions where the emotions have to be inferred, for instance from event descriptions. Further, most datasets do not focus on the cause or the stimulus of the emotion. Here, for the first time, we propose a shared task where systems have to predict the emotions in a large automatically labeled dataset of tweets without access to words denoting emotions. Based on this intention, we call this the Implicit Emotion Shared Task (IEST) because the systems have to infer the emotion mostly from the context. Every tweet has an occurrence of an explicit emotion word that is masked. The tweets are collected in a manner such that they are likely to include a description of the cause of the emotion – the stimulus. Altogether, 30 teams submitted results which range from macro F1 scores of 21 % to 71 %. The baseline (Max-Ent bag of words and bigrams) obtains an F1 score of 60 % which was available to the participants during the development phase. A study with human annotators suggests that automatic methods outperform human predictions, possibly by honing into subtle textual clues not used by humans. Corpora, resources, and results are available at the shared task website at http://implicitemotions.wassa2018. com.
Heterogeneity of programmed death‐ligand 1 expression in thymic epithelial tumours between initial specimen and synchronous or metachronous metastases or recurrences

Thymic epithelial tumors (TET) are rare malignant neoplasms that have the potential to metastasize, recur, or even have a fatal outcome. While many thymomas have a favorable outcome with a 5-year overall survival of 75.8%, reported 5-year survival rates of thymic carcinomas are only 27.5 to 50.5% [1, 2] Complete resection is the curative treatment of choice, however, high stage TET are often not amenable to complete resection. Therefore, alternate treatments such as anti-PD-1/PD-L1 inhibitors, have been studied in this patient population and remain an area of active investigation. This article is protected by copyright. All rights reserved.
Empowering Teachers through Core Reflection : A Case in Korea

This study explored the reflection process of secondary in-service English teachers during a graduate course. In particular, the study aimed to examine the type of reflection the teachers are engaged in as they strive toward experiencing core reflection. In addition, the restricting and contributing factors during the process of reflection were also looked into. A total of 17 in-service secondary English teachers participated in this study. The data were collected from class observations, group discussions, reflective presentations, and interviews. The results of the study showed that they struggled at first due to many restricting factors such as lack of training to conduct structured reflections and ongoing administrative concerns. As they progressed and focused on a particular question that triggered further reflection, they were able to collaboratively reflect on a shared theme. This enabled them to confront their long-term difficulties and finally move forward. The implication of the study points out the importance of proper training to conduct effective reflection on a regular basis and the efforts to provide programs that focus on helping teachers to redefine imported theories and methods so that they can appropriately apply them in their classrooms.
Performance Analysis of IoT-Based Sensor, Big Data Processing, and Machine Learning Model for Real-Time Monitoring System in Automotive Manufacturing

With the increase in the amount of data captured during the manufacturing process, monitoring systems are becoming important factors in decision making for management. Current technologies such as Internet of Things (IoT)-based sensors can be considered a solution to provide efficient monitoring of the manufacturing process. In this study, a real-time monitoring system that utilizes IoT-based sensors, big data processing, and a hybrid prediction model is proposed. Firstly, an IoT-based sensor that collects temperature, humidity, accelerometer, and gyroscope data was developed. The characteristics of IoT-generated sensor data from the manufacturing process are: real-time, large amounts, and unstructured type. The proposed big data processing platform utilizes Apache Kafka as a message queue, Apache Storm as a real-time processing engine and MongoDB to store the sensor data from the manufacturing process. Secondly, for the proposed hybrid prediction model, Density-Based Spatial Clustering of Applications with Noise (DBSCAN)-based outlier detection and Random Forest classification were used to remove outlier sensor data and provide fault detection during the manufacturing process, respectively. The proposed model was evaluated and tested at an automotive manufacturing assembly line in Korea. The results showed that IoT-based sensors and the proposed big data processing system are sufficiently efficient to monitor the manufacturing process. Furthermore, the proposed hybrid prediction model has better fault prediction accuracy than other models given the sensor data as input. The proposed system is expected to support management by improving decision-making and will help prevent unexpected losses caused by faults during the manufacturing process.
Highly specific monoclonal antibodies for allosteric inhibition and immunodetection of the human pancreatic zinc transporter ZnT8

Solute carrier family 30 member 8 (SLC30A8), encoding the pancreatic zinc transporter ZnT8, is a susceptibility gene for type 2 diabetes (T2D). Reducing ZnT8 transport activity or down-regulating its cellular expression is hypothesized to be an antidiabetogenic strategy mimicking the protective effect of SLC30A8 haploinsufficiency in humans. However, research tools to inhibit ZnT8 activity and measure cellular ZnT8 levels are not available. Here, we report the identification of two anti-ZnT8 mAbs applicable to addressing these unmet needs. Both mAbs exhibited subnanomolar affinities for human ZnT8 and were selective against homologous zinc transporters with distinct cross-species reactivities and epitope recognition. We showed that antigen-binding fragments (Fabs) protected ZnT8 from unfolding and inhibited ZnT8-mediated zinc transport in proteoliposomes. Negative-stain EM revealed a ternary binding complex of a ZnT8 monomer and two different Fabs at a 1:1:1 stoichiometry. Moreover, dual bindings of two different mAbs to a single ZnT8 protein multiplied the individual anti-ZnT8 specificities, enabling quantification of cellular ZnT8 levels by homogeneous time-resolved fluorescence (HTRF). Our results demonstrate the utilities of the two generated mAbs as allosteric inhibitors and highly specific biosensors of human ZnT8.
MesoNet: a Compact Facial Video Forgery Detection Network

This paper presents a method to automatically and efficiently detect face tampering in videos, and particularly focuses on two recent techniques used to generate hyper-realistic forged videos: Deepfake and Face2Face. Traditional image forensics techniques are usually not well suited to videos due to the compression that strongly degrades the data. Thus, this paper follows a deep learning approach and presents two networks, both with a low number of layers to focus on the mesoscopic properties of images. We evaluate those fast networks on both an existing dataset and a dataset we have constituted from online videos. The tests demonstrate a very successful detection rate with more than 98% for Deepfake and 95% for Face2Face.
Hypernyms Through Intra-Article Organization in Wikipedia

We introduce a new measure for unsupervised hypernym detection and directionality. The motivation is to keep the measure computationally light and portatable across languages. We show that the relative physical location of words in explanatory articles captures the directionality property. Further, the phrases in section titles of articles about the word, capture the semantic similarity needed for hypernym detection task. We experimentally show that the combination of features coming from these two simple measures suffices to produce results comparable with the best unsupervised measures in terms of the average precision.
The Risk of Adverse Events in Patients With Polycystic Kidney Disease With Advanced Chronic Kidney Disease

Background: Polycystic kidney disease (PKD) leads to progressive chronic kidney disease (CKD) with a subsequent risk of adverse events such as cardiac disease, infections, end-stage kidney disease (ESKD), and mortality. Objectives: To determine the risks of CKD-related adverse outcomes in patients with PKD compared with patients without PKD. Setting: Canadian study of prediction of death, dialysis and interim cardiovascular events (CanPREDDICT) was a prospective pan-Canadian cohort study from 2008-2013 involving 28 facilities with adjudicated outcomes. Patients: Adult CKD patients (estimated glomerular filtration rate [eGFR] = 15-45 mL/min/1.73 m2) under the care of a nephrologist. Measurements: Polycystic kidney disease as identified by the treating physician. Methods: Patients with PKD (PKD) and non-PKD were propensity score (PS) matched (1:4) using demographics, comorbidities, and laboratory values. We used conditional Cox proportional hazards models to examine the risk of cardiac disease (defined as coronary artery disease or congestive heart failure), infection, ESKD, or all-cause mortality in patients with PKD compared with no PKD. Results: Among a total of 2370 patients, 105 with PKD were matched with 416 without PKD with a baseline mean age and eGFR of 62.6 years and 27.8 mL/min, respectively. During 1680 person-years of follow time (median follow-up: 3.8 years), there were a total of 43 cardiac, 83 ESKD, 117 infectious, and 39 all-cause mortality events. PKD was associated with a higher risk of cardiac events (9.5% vs 7.9%, hazard ratio [HR] = 1.46, 95% confidence interval [CI] = 1.04-2.04) and ESKD (25.7% vs 13.5%, HR = 2.00, 95% CI = 1.33-3.01), and with similar risks for infection (21.9% vs 22.6%, HR = 1.16, 95% CI = 0.75-1.82) or all-cause mortality (6.7% vs 7.7%, HR = 0.87, 95% CI = 0.40-1.91) compared with non-PKD. There were no differences in the types of infections (urinary, respiratory, hematologic, or other) between the 2 groups (P = .585). Conclusions: Patients with PKD with advanced CKD are at a potentially higher risk of ESKD and cardiac events compared with patients without PKD. These findings, if confirmed in larger cohorts, suggest that monitoring and treatment for adverse outcomes in patients with PKD, especially related to cardiac disease, may be beneficial.
Ibrutinib Treatment through Nasogastric Tube in a Comatose Patient with Central Nervous System Localization of Mantle Cell Lymphoma

Nowadays, mantle cell lymphoma is considered to have one of the worst prognostic profiles among lymphoid malignancies. Mantle cell lymphoma rarely affects the central nervous system (CNS) as it represents about 0.9% of diagnosis and 4% among recurrent cases. Here, we present the case of a 69-year-old male patient who was diagnosed with mantle cell lymphoma in 2006. The patient relapsed three times, without affecting the CNS, then was treated accordingly, and achieved complete remission three times. Four years after his last complete remission, upon receiving his last dose of treatment, the medical team noted a rapid worsening of the patient's neurological status followed by a deep coma state causing MCL neurological recurrence by exclusion diagnosis. The patient then received ibrutinib via a nasogastric tube at a dose of 560 mg daily. Two days after receiving his last dose of ibrutinib, the patient regained full consciousness, and 10 days later, he was discharged from the hospital. The patient achieved complete remission and showed no signs of neurological damages for 24 months following his ibrutinib treatment. We believe that the administration of ibrutinib through the nasogastric tube was a determinant factor in this patient's remission and survival.
Finding the Answers with Definition Models

Inspired by a previous attempt to answer crossword questions using neural networks (Hill, Cho, Korhonen, & Bengio, 2015), this dissertation implements extensions to improve the performance of this existing definition model on the task of answering crossword questions. A discussion and evaluation of the original implementation finds that there are some ways in which the recurrent neural model could be extended. Insights from related fields neural language modeling and neural machine translation provide the justification and means required for these extensions. Two extensions are applied to the LSTM encoder, first taking the average of LSTM states across the sequence and secondly using a bidirectional LSTM, both implementations serve to improve model performance on a definitions and crossword test set. In order to improve performance on crossword questions, the training data is increased to include crossword questions and answers, and this serves to improve results on definitions as well as crossword questions. The final experiments are conducted using sub-word unit segmentation, first on the source side and then later preliminary experimentation is conducted to facilitate character-level output. Initially, an exact reproduction of the baseline results proves unsuccessful. Despite this, the extensions improve performance, allowing the definition model to surpass the performance of the recurrent neural network variants of the previous work (Hill, et al., 2015).
Therapeutic Drug Monitoring of Vancomycin in Pediatric Patients With Extracorporeal Membrane Oxygenation Support.

OBJECTIVES Determine pharmacokinetic (PK) parameters and optimal dosage of vancomycin for children on extracorporeal membrane oxygenation (ECMO). METHODS Retrospective PK study of vancomycin in pediatric patients on ECMO who received IV vancomycin 40 to 60 mg/kg/day every 6 hours. Patients were analyzed according to the presence of acute kidney injury (AKI) and requirement of renal replacement therapy (RRT). RESULTS Data from 40 children, with a median age of 2.7 years of age (1 month to 14 years) were evaluated. Thirty-two patients (80%) received vancomycin. Vancomycin therapeutic drug monitoring was performed in 29 patients. The subgroup without AKI or RRT were 15. With initial doses, vancomycin trough levels were within therapeutic range in 53% of patients. After dose change, 93% of patients achieved therapeutic levels. The adjusted dose was 40 (34-60) mg/kg/day every 6 hours. Estimated PK parameters were clearance (CL) 1.67 (1-1.67) mL/kg/min; volume of distribution (Vd) 0.73 (0.7-0.9) L/kg; and half-life (t½) 6.2 (4.9-8.06) hours. In the AKI subgroup, 11 patients, the initial median dose was 40 (30-45) mg/kg/day every 8 (6-12) hours. Trough concentrations of vancomycin were within therapeutic range in 27% of patients. After dose modifications, 63% of patients achieved target trough concentration. The final adjusted dose was 20 mg/kg/day (15-30) every 12 (12-24) hours. Estimated PK parameters were Vd 1.16 (0.68-1.6) L/kg; CL 0.83 (0.38-1) mL/kg/min; and a t½ of 23.6 (16.2-31) hours. CONCLUSIONS In patients without AKI or RRT, Vd of vancomycin was similar and CL was lower compared to pediatric critically ill patients without ECMO. Treatment could be started at 40 mg/kg/day every 6 hours. In patients with AKI, the use of lower doses should be used.
Two-Level Transmission Scheme for Cache-Enabled Fog Radio Access Networks

In this paper, we investigate the downlink transmission for cache-enabled fog radio access networks aiming at maximizing the delivery rate under the constraints of fronthaul capacity, maximum transmit power, and size of files. To reduce the delivery latency and the burden on fronthaul links and make full use of the local cache and baseband signal processing capabilities of enhanced remote radio heads (eRRHs), a two-level transmission scheme including cache-level and network-level transmission is proposed. In cache-level transmission, only requested files cached at the local cache are transmitted to the corresponding users. The duration of cache-level transmission is the delay caused by the transfer between the baseband unit (BBU) and eRRHs as well as the signal processing at the BBU. The remaining requested files are jointly transmitted to the corresponding users at network-level transmission. For cache-level transmission, a centralized optimization algorithm is first presented and then a decentralized optimization algorithm is provided to avoid the exchange of signaling among eRRHs. Meanwhile, another centralized optimization algorithm is presented to tackle the optimization problem for network-level transmission. All presented algorithms are proved to converge to the Karush–Kuhn–Tucker solutions of the problems. Numerical results are provided to validate the effectiveness of the proposed transmission scheme as well as evaluating the system performance.
Factors influencing nursing students’ empathy

Purpose This study attempted to examine nursing students’ self-esteem, interpersonal relationships, and self-efficacy, to identify factors affecting empathy. Methods A predictive correlational design was used. The participants in this study were nursing students from fours university of Korea. The questionnaires were administered to a convenience sample of 147 nursing students in the Republic of Korea. Results Mean item scores for self-esteem, interpersonal relationship, self-efficacy, and empathy were 3.83, 3.63, 3.30, and 3.44, respectively (possible range, 1–5). Empathy was correlated with self-esteem, interpersonal relationships, and self-efficacy. The multiple regression analysis revealed that 45.9% of the variance in empathy is attributable to gender, major satisfaction, self-esteem, self-efficacy, and interpersonal relationships. The most important factor interpersonal relationship explained. Conclusion Improving nursing students’ major satisfaction, self-esteem, self-efficacy, and interpersonal relationships are strategies that may foster empathy.
The Application of Three-Dimensional Printed Finger Splints for Post Hand Burn Patients: A Case Series Investigation

The application of three-dimensional (3D) printing is growing explosively in the medical field, and is especially widespread in the clinical use of fabricating upper limb orthosis and prosthesis. Advantages of 3D-printed orthosis compared to conventional ones include its lower cost, easier modification, and faster fabrication. Hands are the most common body parts involved with burn victims and one of the main complications of hand burns are finger joint contractures. Applying orthotic devices such as finger splints are a well-established essential element of burn care. In spite of the rapid evolution of the clinical use of 3D printing, to our knowledge, its application to hand burn patients has not yet been reported. In this study, the authors present a series of patients with hand burn injuries whose orthotic needs were fulfilled with the application of 3D-printed finger splints.
Evolutionary transitions between beneficial and phytopathogenic Rhodococcus challenge disease management

Understanding how bacteria affect plant health is crucial for developing sustainable crop production systems. We coupled ecological sampling and genome sequencing to characterize the population genetic history of Rhodococcus and the distribution patterns of virulence plasmids in isolates from nurseries. Analysis of chromosome sequences shows that plants host multiple lineages of Rhodococcus, and suggested that these bacteria are transmitted due to independent introductions, reservoir populations, and point source outbreaks. We demonstrate that isolates lacking virulence genes promote beneficial plant growth, and that the acquisition of a virulence plasmid is sufficient to transition beneficial symbionts to phytopathogens. This evolutionary transition, along with the distribution patterns of plasmids, reveals the impact of horizontal gene transfer in rapidly generating new pathogenic lineages and provides an alternative explanation for pathogen transmission patterns. Results also uncovered a misdiagnosed epidemic that implicated beneficial Rhodococcus bacteria as pathogens of pistachio. The misdiagnosis perpetuated the unnecessary removal of trees and exacerbated economic losses.