Miracle-dz/UniFAR-FTUs huggingface dataset:
New Neolithic Sites in Dorset and Bedfordshire, with a Note on the Distribution of Neolithic Storage-Pits in Britain

This discovery was made as a result of rescue excavation in advance of road improvements by the Dorset County Council in the autumn of 1962. The site (NGR SY/99789918) now lies in the north verge of the A31 trunk road, 500 feet towards Wimborne Minster from the new Lake junction to Corfe Mullen, but in 1962 it was still included in field No. 7924, belonging to Lake Farm. Here the land, which forms part of the flood-plain of the Stour, is crossed by a spur of slightly more elevated ground extending north from Willetts Lane. There is a gentle slope westwards from the site towards the Chillwater Stream, which flows north to the Stour after descending from higher ground. The lowlying terrain to the west of this low spur used to be marshland until its reclamation, accounting for the name ‘lake’ given to the locality. The subsoil of the valley-bottom is composed variously of gravel, shingly stones and brown alluvial loam. The original vegetational cover would have been woodland of deciduous type, extending from the floor of the valley up the slope to the south and thinning out to scrub and heath on the gravel plateau 150 feet above the Stour. Today, pasture dominates the scene, with oak prominent only in hedgerow or isolated clumps. The pit to be described below lay just over half a mile to the north-east of the site of one similar in shape and contents that was discovered in a quarry in Corfe Mullen parish some twenty-five years ago.
Slow internalization of human chorionic gonadotropin by cultured granulosa cells

Kinetic studies were performed on two‐day cultures of rat ovarian granulosa cells to follow the fate of surface‐bound 125l‐labeled human chorionic gonadotropin (125l‐hCG). Low pH was used to release hCG from its surface receptor, allowing us to distinguish between surface‐bound and internalized hormone. Because our results indicated that hormone is lost from the cell surface by dissociation as well as internalization, equations were derived to determine independent rate constants for each process. We calculate that if hormone binding were irreversible, the t1/2 for internalization would be 8.5 hours. Morphometric studies on the uptake of horseradish peroxidase indicate that the t1/2 for internalization of bulk membrane in granulosa cells is 55 to 77 minutes. Thus, the rate of uptake of surface‐bound hCG appears to be seven to nine times slower than the rate of uptake of bulk plasma membrane, which suggests that the LH/hCG receptor may be selectively excluded from the endocytic vesicles of granulosa cells.
Investigating consistent patterns of variation in short-notice cancellations of elective operations: The potential for learning and improvement through multi-site evaluations

As part of efforts to increase productivity in healthcare, there is considerable interest in the extent and causes of variation in the performance of provider organisations. In this study, we use publically available data from the English NHS to examine the characteristics of variation in the rates of short-notice cancellations of elective operations due to hospital reasons (e.g. lack of the required resources such as operating theatres and beds). We find that the variation between hospital trusts is very non-random. There is a fourfold difference in the cancellation rates between the top and bottom deciles of performance. Little is known about the causes of this. There is a large and striking consistency in the relative performance of hospital trusts on cancellation rates over the last five years. Thus, the best and worst performers are consistently relatively very good or very poor, so a multi-site comparison of practices, and accounting for confounds like patient demographics, could be very valuable to inform both this knowledge gap and practice in healthcare. Of particular interest is that the cancellation rates could be a symptom of deeper issues with the efficiency of patient flows within hospitals.
Effectiveness of Decongestive Lymphatic Therapy in Patients with Lymphedema Resulting from Breast Cancer Treatment Regardless of Previous Lymphedema Treatment

Decongestive lymphatic therapy (DLT) has gained wide acceptance as an effective treatment for patients with lymphedema resulting from breast cancer treatment. It is unclear whether DLT is effective for patients with lymphedema who have received lymphedema treatment previously. Our purpose was to compare the effectiveness of DLT in patients who had received lymphedema treatment previously with those who had never received treatment. We retrospectively reviewed the medical records of 98 patients who received outpatient lymphedema therapy for upper extremity lymphedema following surgery. Seventy‐two eligible patients with a breast cancer diagnosis and complete medical records were divided into two groups: group 1; previously treated (PT) patients (n = 38, 53%) had previously received lymphedema treatment, while group 2 (no PT, n = 34, 47%) had never received lymphedema treatment. The primary outcome was the percent change in volume in the lymphedematous arm, measured by perometer, after DLT treatment. The two groups did not differ significantly in age, comorbidities, body mass index, and median time from surgery to current treatment, surgical procedure, previous radiation treatment, or history of cellulitis/lymphangitis. DLT significantly reduced arm volume in both groups (group 1, p < 0.001; group 2, p = 0.003). The mean percent volume reduction did not differ significantly between the groups (p = 0.619). This study is the first to show that, DLT reduce limb volume significantly with post‐mastectomy lymphedema, regardless of previous lymphedema therapy.
Edoardo Mollona ' ' Liability ' ' ? Simulating Dynamic Capabilities and Value Creation in Family Firms : Is Paternalism an ' ' Asset ' ' or a

The authors conduct a simulation study using system dynamics methods to interpret how and when paternalism affects dynamic capabilities (DCs) and by association value creation in family firms. Their simulation experiments suggest that the effect of paternalism on DCs and value creation varies over time. Initially, increasing levels of family social capital and low levels of paternalism are associated with high rates of DCs and value creation accumulation (asset). Later, higher levels of paternalism produce their pressure to decrease DCs, value creation, and family social capital accumulation rates (liability).
Immunoglobulin Classes of Antibodies in Milk of Swine After Intranasal Exposure to Pseudorabies Virus or Transmissible Gastroenteritis Virus

Experiments were conducted to evaluate whether infection of the respiratory tract of pregnant swine with pseudorabies (Pr) virus would induce the secretion of immunoglobulin A (IgA) antibodies in their milk as was observed after enteric infection with transmissible gastroenteritis (TGE) virus. The immune response of sows to Pr virus inoculated intranasally and to TGE virus inoculated orally/intranasally or via a natural infection was studied. Emphasis was placed upon titers and Ig classes of Pr and TGE virus-neutralizing antibodies in colostrum and milk. All animals exposed to Pr virus (alone or in combination with TGE virus) developed Pr-neutralizing antibody titers in both serum and milk. Pr antibody titers were generally higher in colostrum than in serum, but the opposite was true in milk compared with serum, with milk titers declining markedly during lactation. In contrast, TGE antibody titers in milk from experimentally or naturally infected sows usually remained higher than the corresponding serum titers and persisted at relatively constant levels throughout lactation. Gel filtration studies of milk indicated that the antibody activity against Pr virus was associated almost entirely with IgG fractions, with small amounts of antibody detectable in IgM fractions in colostrum from two of nine sows. By comparison, TGE antibodies were primarily of the IgA class, with varying but lesser amounts of antibody associated with the IgG class. Such results suggest that viral infection of the intestinal tract of the sow, but not the upper respiratory tract, stimulates the secretion of IgA antibodies in the milk.
Return to Play and Performance After Jones Fracture in National Basketball Association Athletes

Background: Basketball players are at risk for foot injuries, including Jones fractures. It is unknown how this injury affects the future play and performance of athletes. Hypothesis: National Basketball Association (NBA) players who sustain Jones fractures of the base of the fifth metatarsal have high rates of return to play and do not experience a decrease in performance on return to competition when compared with preinjury and with control-matched peers. Study Design: Retrospective cohort study. Level of Evidence: Level 5. Methods: Data on 26 elite basketball players with Jones fractures over 19 NBA seasons (1994-1995 to 2012-2013) were obtained from injury reports, press releases, player profiles, and online public databases. Variables included age, body mass index (BMI), player position, experience, and surgical treatment. Individual season statistics pre- and postinjury were collected. Twenty-six controls were identified by matched player position, age, and performance statistics. Results: The mean age at the time of injury was 24.8 years, mean BMI was 24.7 kg/m2, and the mean experience prior to injury was 4.1 NBA seasons. Return to previous level of competition was achieved by 85% of athletes. There was no change in player efficiency rating (PER) when pre- and postinjury performance was compared. When compared with controls, no decline in PER measured performance was identified. Conclusion: The majority of NBA players sustaining a Jones fracture return to their preinjury level of competition. These elite athletes demonstrate no decrease in performance on their return to play. Clinical Relevance: Jones fractures are well-studied injuries in terms of etiology, diagnosis, and management. However, the effect of these injuries on future performance of athletes is unknown. Using the findings of our study, orthopaedic surgeons may be better prepared to counsel and educate elite athletes who sustain a Jones fracture.
The Single-Case Reporting Guideline In BEhavioural Interventions (SCRIBE) 2016 statement

We developed a reporting guideline to provide authors with guidance about what should be reported when writing a paper for publication in a scientific journal using a particular type of research design: the single-case experimental design. This report describes the methods used to develop the Single-Case Reporting guideline In BEhavioural interventions (SCRIBE) 2016. As a result of 2 online surveys and a 2-day meeting of experts, the SCRIBE 2016 checklist was developed, which is a set of 26 items that authors need to address when writing about single-case research. This article complements the more detailed SCRIBE 2016 Explanation and Elaboration article (Tate et al., 2016) that provides a rationale for each of the items and examples of adequate reporting from the literature. Both these resources will assist authors to prepare reports of single-case research with clarity, completeness, accuracy, and transparency. They will also provide journal reviewers and editors with a practical checklist against which such reports may be critically evaluated. We recommend that the SCRIBE 2016 is used by authors preparing manuscripts describing single-case research for publication, as well as journal reviewers and editors who are evaluating such manuscripts. Reporting guidelines, such as the Consolidated Standards of Reporting Trials (CONSORT) Statement, improve the reporting of research in the medical literature (Turner et al., 2012). Many such guidelines exist and the CONSORT Extension to Nonpharmacological Trials (Boutron et al., 2008) provides suitable guidance for reporting between-groups intervention studies in the behavioral sciences. The CONSORT Extension for N-of-1 Trials (CENT 2015) was developed for multiple crossover trials with single individuals in the medical sciences (Shamseer et al., 2015; Vohra et al., 2015), but there is no reporting guideline in the CONSORT tradition for single-case research used in the behavioral sciences. We developed the Single-Case Reporting guideline In BEhavioural interventions (SCRIBE) 2016 to meet this need. This Statement article describes the methodology of the development of the SCRIBE 2016, along with the outcome of 2 Delphi surveys and a consensus meeting of experts. We present the resulting 26-item SCRIBE 2016 checklist. The article complements the more detailed SCRIBE 2016 Explanation and Elaboration article (Tate et al., 2016) that provides a rationale for each of the items and examples of adequate reporting from the literature. Both these resources will assist authors to prepare reports of single-case research with clarity, completeness, accuracy, and transparency. They will also provide journal reviewers and editors with a practical checklist against which such reports may be critically evaluated.
Studies of food-intake regulation in man. Responses to variations in nutritive density in lean and obese subjects.

Abstract The effect on spontaneous food intake of concealed variations in nutritive density of machine-dispensed liquid diet was studied in five lean and four obese young adults and two obese juvenile subjects. They were unaware of the changes in caloric concentration and that food intake was being monitored. The lean subjects maintained weight during machine feeding, and when nutritive density was altered, promptly adjusted the volume consumed to maintain near constant energy intake. The obese adults ingested a small fraction of the calories needed to maintain weight and failed to adapt volume intake to appreciable changes in caloric concentration. The obese juvenile subjects consumed large quantities of formula however, one also failed to adjust volume intake when caloric density was varied. Lean young adults appear to regulate energy intake at the physiologic level when the nutritive concentration of the diet is altered covertly. Grossly obese adults seem incapable of such regulation.
Gap Area and Tree Community Regeneration in a Tropical Semideciduous Forest

In tropical and temperate forests, the canopy gaps affect the architecture and the establishment of plants throughout their life-cycle. The gaps help to maintain the tree diversity by density effect and niche partitioning. The possibility of gap occurrence particularly interplays with recruitment limitation, allowing the coexistence of species that otherwise could not make it (Brokaw & Busing 2000; Lima, 2005; Gravel et al., 2010). A typical canopy gap goes through diverse stages, the initial one known as gap stage. In this stage, the invasion by lianas (Schnitzer & Carson, 2010) and bamboos (Larpkern et al., 2011) might occur. The next stage is the construction stage, in which the establishment of some species occurs, although they have not yet reached the canopy level. The last stage is the mature one, in which the canopy and the gap are virtually closed by true vegetation (Lima, 2005).
Clinical profile of chikungunya fever in patients in a tertiary care centre in Maharashtra, India.

BACKGROUND & OBJECTIVE In India a chikungunya fever outbreak started in December 2005 when the country experienced more than 13 lakhs of chikungunya infected cases. We undertook this study to study detailed clinical profile of chikungunya fever in both indoor and outdoor patients in a tertiary care hospital in Nagpur, Maharashtra in 2006. METHODS Suspected cases of chikungunya fever (n=405) during the period of July to September 2006, having clinical triad of fever, arthralgia and/or rashes were included in the study. Clinical profile was studied in all the cases. Of the 405 samples collected, 166 were tested for serum CHIK IgM antibodies. RESULTS Of the 166 samples tested for CHIKV IgM antibodies, 87 (52.4%) were positive (confirmed cases). Male: female ratio was 2.3:1. Fever and arthralgia were present in all cases. Rash was present in 27 (31%) confirmed and 38 (12%) suspected cases. Lymphadenopathy was present in 12 (13.8 %) confirmed and 4 of suspected cases. Chronic polyarthritis was seen in 22 (25.3%) confirmed and 75 (23.6%) suspected cases. Neurological manifestations were observed in 08 (9%) confirmed and 10 (3.14%) suspected cases. Mortality was 7 (2.2%) in 318 suspected cases and 3 (3.4%) in 87 confirmed cases. INTERPRETATION & CONCLUSION Our findings showed that about half of the serum samples for CHIKV IgM antibody tested positive from cases suspected to have chikungunya fever. Fever, joint pain and headache were major symptoms. Certain rare manifestations like lymphodenopathy, oral ulcers and encephalitis were also seen. Mortality in confirmed cases was about 3.4 per cent.
Serum Leptin, Ferritin and Uric Acid as Predictors of Fibrosis and Sustained Virological Response in Chronic Hepatitis C Patients

Hyperleptinemia, hyperferritinemia and hyperuricemia have been implicated in hepatic inflammation and fibrosis and assumed to be predictors of poor response to antiviral therapy. The aim of study is to evaluate the role of serum leptin, ferritin and uric acid in progression of chronic hepatitis C (CHC) disease and their role in detection of virological response to combined antiviral therapy (pegylated interferon PEG-IFN-α/ribavirin RBV). Study design is a prospective study; conducted on 40 patients with CHC infection eligible for treatment with combined antiviral therapy before the combined antiviral therapy introduced and 30 healthy volunteers as controls. Patients with chronic liver disease due to other causes were excluded from the study. All patients and controls were subjected to through clinical evaluation, abdominal ultrasonography, complete blood picture (CBC), liver enzymes (AST/ALT), total bilirubin and leptin, ferritin and uric acid investigations. Plasma HCV-RNA viral load by real- time polymerase chain reaction (PCR) and liver biopsy using Metavir score were done for HCV patients only. We compared level of serum leptin, ferritin and uric acid level between patients and with controls. We estimated serum leptin and ferritin sensitivity, specificity and accuracy in both responders and non-responders to treatment. Study findings were as the follow: serum leptin and ferritin higher concentrations were predictive factors to failure of combined antiviral treatment and correlated with inflammatory activity and advanced liver fibrosis. Serum uric acid level was not significantly associated with inflammatory activity, stage of hepatic fibrosis and interferon treatment failure. In Conclusion CHC is associated with higher leptin and ferritin levels. High serum leptin and ferritin levels are negative predictors of response to combined antiviral treatment in CHC. Serum leptin had higher sensitivity, specificity and accuracy than serum ferritin; so leptin considered better than ferritin in prediction of response to antiviral therapy in chronic HCV patients.
Corporate Governance and Capital Markets: A Conceptual Framework

This paper outlines a conceptual framework of the relationship between corporate governance and two important determinants of capital market development namely, a firm’s access to finance, and its financial performance. The framework assumes that a firm’s corporate governance is simultaneously determined by a group of related governance components and other firm characteristics. Whilst the capital markets play a crucial role in enhancing corporate governance standards, the effectiveness and credibility of such effort might be constrained by poor firm-level corporate governance. Moreover, the cause and effect relationship can work in the opposite direction e.g. firm-level corporate governance quality can enhance both the firm’s ability to gain access to finance and its financial performance, which eventually lead to capital market development. The framework is primarily based on the economic approaches to corporate governance, although it recognises part of the assumptions of the stakeholder theory and the political economy aspects of corporate governance.
Cloning and characterization of osteoclast precursors from the raw264.7 cell line

SummaryOsteoclasts are bone-resorbing cells that differentiate from macrophage precursors in response to receptor activator of NF-κB ligand (RANKL). In vitro models of osteoclast differentiation are principally based on primary cell cultures, which are poorly suited to molecular and transgene studies because of the limitations associated with the use of primary macrophage. RAW264.7 is a transfectable macrophage cell line with the capacity to form osteoclast-like cells. In the present study, we have identified osteoclast precursors among clones of RAW264.7 cells. RAW264.7 cell were cloned by limiting dilution and induced to osteoclast differentiation by treatment with recombinant RANKL. Individual RAW264.7 cell clones formed tartrate resistant acid phosphatase (TRAP)-positive multinuclear cells to various degrees with RANKL treatment. All clones tested expressed the RANKL receptor RANK. Each of the clones expressed the osteoclast marker genes TRAP and cathepsin-K mRNA with RANKL treatment. However, we noted that only select clones were able to form large, well-spread, TRAP-positive multinuclear cells. Clones capable of forming large TRAP-positive multinuclear cells also expressed β3 integrin and calcitonin receptor mRNAs and were capable of resorbing a mineralized matrix. All clones tested activated NF-κB with RANKL treatment. cDNA expression profiling of osteoclast precursor RAW264.7 cell clones demonstrates appropriate expression of a large number of genes before and after osteoclastic differentiation. These osteoclast precursor RAW264.7 cell clones provide a valuable model for dissecting the cellular and molecular regulation of osteoclast differentiation and activation.
Multiple window access antrostomy in maxillary sinus grafting. Presentation of a clinical serie of 10 cases and literature review

Objectives: A variation on the usual maxillary sinus grafting technique and its results are presented, using a more conservative approach that provides better conditions for applying the graft in complicated situations. Material and Methods: Ten case reports are presented in which the multiple access technique was used due to the existence of large maxillary sinuses, where a wide surgical approach was needed because several implants were to be installed or cases in which sinus bone graft was part of a more extensive reconstructive prodedure. Results: All the implants that were placed after using this technique were correctly integrated and it was possible to proceed to the prosthesis stage without any problems. Conclusions: This modified technique of sinus floor bone grafting can have a beneficial effect with a lower risk of perforations, better preservation of vascularisation in the area and improved integration and stability of the implants and bone graft, specially where wider surgical access is required.