Miracle-dz/UniFAR-FTUs huggingface dataset:
A prospective study of the immune reconstitution inflammatory syndrome (IRIS) in HIV-infected children from high prevalence countries

Background The immune reconstitution inflammatory syndrome (IRIS) in HIV-infected infants and young children is relatively understudied in regions endemic for HIV and TB. We aimed to describe incidence, clinical features and risk factors of pediatric IRIS in Sub-Saharan Africa and India. Methods and findings We conducted an observational multi-centred prospective clinical study from December 2010 to September 2013 in children <72 months of age recruited from public antiretroviral programs. The main diagnostic criterion for IRIS was a new or worsening inflammatory event after initiating antiretroviral therapy (ART). Among 198 participants, median age 1.15 (0.48; 2.21) years, 38 children (18.8%) developed 45 episodes of IRIS. Five participants (13.2%) had two IRIS events and one (2.6%) had 3 events. Main causes of IRIS were BCG (n = 21; 46.7%), tuberculosis (n = 10; 22.2%) and dermatological, (n = 8, 17.8%). Four TB IRIS cases had severe morbidity including 1 fatality. Cytomegalovirus colitis and cryptococcal meningitis IRIS were also severe. BCG IRIS resolved without pharmacological intervention. On multivariate logistic regression, the most important baseline associations with IRIS were high HIV viral load (likelihood ratio [LR] 10.629; p = 0.0011), recruitment at 1 site (Stellenbosch University) (LR 4.01; p = 0.0452) and CD4 depletion (LR 3.4; p = 0.0654). Significantly more non-IRIS infectious and inflammatory events between days 4 and 17 of ART initiation were noted in cases versus controls (35% versus 15.2%: p = 0.0007). Conclusions IRIS occurs commonly in HIV-infected children initiating ART and occasionally has severe morbidity. The incidence may be underestimated. Predictive, diagnostic and prognostic biomarkers are needed.
Predictors of Poor Global Alignment and Proportion Score After Surgery for Adult Spinal Deformity.

MINI: GAP score might define targets for sagittal spinopelvic alignment for favorable outcomes of corrective surgery for adult spinal deformity, including "amplitude of lumbar lordosis," the proportion of lumbar lordosis or pelvic parameters, or both. A large preoperative global tilt is a potential predictor of poor postoperative GAP score. STUDY DESIGN Retrospective observational study of a cohort of consecutive patients. OBJECTIVE To determine 1) the correlation between clinical and radiographic outcomes and Global Alignment and Proportion (GAP) score, and 2) which preoperative parameters predominantly influence the risk for poor GAP scores. SUMMARY OF BACKGROUND DATA Although numerous investigators have indicated their criteria for sagittal correction, it is still not unusual to observe poor outcome or complications even after ideal correction. The recently developed GAP score indicates spinopelvic alignment and setting surgical goals according to the score might decrease the prevalence of mechanical complications. However, there is no clear evidence of correlation between the GAP score and clinical outcomes, or which patient factors are preoperative predictors of poor postoperative GAP score. METHODS We included 128 consecutive patients treated with spinal correction surgery who had a minimum 2-year follow-up. The correlations between clinical outcomes, increased proximal junctional angle, and GAP score were determined. Univariate and multivariate logistic regression analyses were conducted to clarify potential preoperative risk factors for poor GAP score. RESULTS Based on total GAP score, 32 (25%) patients were grouped into proportioned, 50 (39.1%) into moderately disproportioned, and 44 (34.3%) into severely disproportioned spinopelvic alignment. Our present study showed a significantly positive correlation between Oswestry Disability Index, increased proximal junctional angle 2 years after surgery, and total GAP score. Uni and multivariate regression analysis showed a large global tilt was a risk factor for a poor GAP score and that the risk for a poor GAP score increased with ageing. CONCLUSIONS Because GAP score correlated with Oswestry Disability Index and increased proximal junctional angle 2 years after surgery, GAP score might define targets for sagittal spinopelvic alignment for favorable outcomes of corrective spinal surgery. A large preoperative global tilt is a potential predictor of poor postoperative GAP score. LEVEL OF EVIDENCE 3.
Associations between Snacking and Weight Status among Adolescents 12–19 Years in the United States

Snacking is a significant contributor to energy intake among adolescents, but its association with weight status is unclear. To elucidate this association, data from 6545 adolescents (12–19 years) in the 2005–2016 National Health and Nutrition Examination Survey (NHANES) were analyzed. The mean number of daily snack occasions, mean snack size, and mean snack energy density were examined by weight classification (body mass index (BMI)-for-age percentiles: normal weight (NW) <85th; overweight (OW) ≥85th to <95th; obese (OB) ≥95th). Models included all snacking parameters, mean meal size, demographic characteristics, survey cycle year, and dietary reporting accuracy. Adolescents with NW consumed fewer snacks daily (1.69 (0.02) snacks/day) and smaller snacks per occasion (262.32 (4.41) calories (kcal)/snack) compared to adolescents with OW (1.85 (0.05) snacks/day, p = 0.005; 305.41 (8.84) kcal/snack, p < 0.001), and OB (1.97 (0.05) snacks/day; 339.60 (10.12) kcal/snack, both p < 0.001). Adolescents with OW and OB also consumed more added sugar, saturated fat and sodium from snacks, but had lower mean energy density per snack compared to snacks consumed by NW adolescents. US adolescents with OW and OB consume more snacks daily and more calories at each snacking occasion compared to adolescents with NW. Future studies should examine the prospective associations between snacking and weight status and impact on overall diet quality.
Dang-Ki healing: An embodied relational healing practice in Singapore

This article explores the processes of transformation of the self in dang-ki healing, a form of Chinese spirit mediumship in Singapore, drawing on more than a decade of ethnographic research. In dang-ki healing, it is believed that a deity possesses a human, who is called a dang-ki, to help clients (i.e., devotees). Through the dang-ki, clients can interact with powerful deities in ways that help them feel hopeful and supported. The dang-kis themselves may also benefit therapeutically from their participation as mediums. Many dang-kis suffer from personal conflicts and distress before becoming a medium and they express and transform their distress through the idiom of spirit possession. Since deities represent traits and moral values promoted in Chinese culture, possession by a deity allows the dang-ki to embody an ideal self and to acquire spiritual knowledge by engaging in ritual practices involving cleansing, self-mortification, stereotyped movements, and altered consciousness. At the same time, junior possessing deities must undergo training under the guidance of senior deities to achieve a higher level of spiritual existence by helping clients through the dang-ki's body. Thus, in dang-ki healing, practitioners, clients and possessing deities are transformed in parallel ways. The dynamics of this reciprocal and interdependent healing process differ from the individualistic approaches in Western psychotherapy and shed light on the links between healing processes, cultural ontologies, and concepts of personhood.
Positive and negative incentive contrasts lead to relative value perception in ants

Humans usually assess things not according to their absolute value, but relative to reference points – a main tenant of Prospect Theory. For example, people rate a new salary relative to previous salaries and salaries of their peers, rather than absolute income. We demonstrate a similar effect in an insect: ants expecting to find low-quality food showed higher acceptance of medium-quality food than ants expecting medium quality, and vice versa for high expectations. Further experiments demonstrate that these contrast effects arise from cognitive rather than mere sensory or pre-cognitive perceptual causes. Social information gained inside the nest can also serve as a reference point: the quality of food received from other ants affected the perceived value of food found later. Value judgement is a key element in decision making, and thus relative value perception strongly influences which option is chosen and ultimately how all animals make decisions.
Glucose Ingestion Inhibits Endurance Exercise-Induced IL-6 Producing Macrophage Infiltration in Mice Muscle

Background: Carbohydrate (CHO) supplementation during exercise attenuates exercise-induced increases in plasma Interleukin (IL)-6 concentration. However, the effects of CHO supplementation on muscle IL-6 production during endurance exercise is controversial. The purpose of this study was to investigate the effects of CHO supplementation on muscle IL-6 production during endurance exercise with a special focus on the IL-6 producing cells. Methods: C57BL/6J mice were divided into three groups—sedentary with water ingestion group as the control (Con; n = 10), exercise with water ingestion group (Ex; n = 10), and exercise with 6% glucose ingestion group (Ex + glucose; n = 10). The Ex and Ex + glucose groups completed 3 h of treadmill running (24 m/min, 7% incline) and were sacrificed immediately after exercise. Results: The exercise-induced increases of plasma IL-6 concentration and gastrocnemius IL-6 gene expression were attenuated by glucose ingestion. However, the increases of soleus IL-6 gene expression and gastrocnemius and soleus IL-6 protein expression were not attenuated by glucose ingestion. Furthermore, we observed that macrophages that infiltrated muscle produce IL-6 and glucose ingestion attenuated the infiltration of IL-6-producing macrophages. Conclusion: This study revealed that infiltrating macrophages may be one type of IL-6-producing cells during endurance exercise, and the infiltration of these cells in muscle was attenuated by glucose ingestion. However, the effects of glucose ingestion on muscle IL-6 production were limited.
Shaping the future of an ultra-rare disease: unmet needs in the diagnosis and treatment of pulmonary alveolar proteinosis.

PURPOSE OF REVIEW Pulmonary alveolar proteinosis (PAP) can be considered the archetype of ultra-rare diseases with a prevalence of under 10 cases per million. We discuss the classification of PAP, the current diagnostic practice and the supplementary role of genetic testing and granulocyte-macrophage colony-stimulating factor (GM-CSF) signalling in the diagnosis of congenital and hereditary PAP. We report on novel therapeutic approaches such as GM-CSF substitution, stem cell transplantation, pioglitazone, statins and immunomodulation. RECENT FINDINGS The discovery of new genetic mutations underlying this syndrome raises the question whether the classification should be radically revised in the future. Serum GM-CSF autoantibody is the best diagnostic marker for autoimmune PAP, the most common form, but does not correlate with disease severity. Several circulating biomarkers have been investigated to assess disease activity and predict outcome. Imaging techniques have also enormously evolved and offer new tools to quantify disease burden and possibly drive therapeutic decisions. Promising clinical trials are ongoing and will generate new treatment strategies besides or in addition to whole lung lavage in the next future. SUMMARY Despite impressive advances in understanding pathogenesis, PAP remains a rare syndrome with several unanswered questions impacting diagnosis, management and treatment, and, as a result, patients' quality of life.
Is cognitive grammar a usage-based model?Towards a realistic account of English sentential complements

As pointed out by Newmeyer (2003: 683), the term usage-based was coined by Langacker (FCG1: 46, 494) to refer to those approaches which, as is the case with Cognitive Grammar (CG), reject a sharp distinction between language knowledge and language use. In a usage-based approach, knowledge of a language is seen as based in knowledge of actual usage and of generalizations made over usage events. Language acquisition is therefore a bottom-up process, driven by linguistic experience. Unlike generative grammar, which, in Langacker’s (FCG1: 46) words, has “always operated with an archetypal conception of language as a system of general rules, and [has] therefore not accommodated irregular and idiosyncratic phenomena in a natural or convincing manner”, a usage-based theory is claimed to give “substantial importance [. ] to the actual use of the linguistic system and a speaker’s knowledge of this use” (ibid.: 494; see also Langacker 1999: 91-145).
Diagnostic Usefulness of Cytokine and Chemokine Levels in the Cerebrospinal Fluid of Patients with Suspected Tuberculous Meningitis.

In this study, we investigated the diagnostic utility of the cytokine profile of the cerebrospinal fluid (CSF) of patients with suspected tuberculous meningitis (TBM) and the use of enzyme-linked immunospot (ELISPOT) assay. We prospectively enrolled adult patients with suspected TBM, and CSF specimens were analyzed for 18 cytokines/chemokines and soluble programmed death protein 1 (PD-1) and programmed death ligand 1 (PD-L1). Enzyme-linked immunospot assays were performed on mononuclear cells from the CSF (CSF-MCs) and peripheral blood (PBMCs). A total of 87 patients with meningitis, including 42 TBM-suspected patients and 45 non-TBM patients, were enrolled. Excluding the 32 patients with possible TBM, 10 patients with TBM and 45 patients with non-TBM were finally analyzed. Levels of adenosine deaminase (ADA), interleukin 12 subunit β (IL-12p40), IL-13, macrophage inflammatory protein α (MIP-1α), and soluble PD-1 and PD-L1 in the CSF were significantly higher in the TBM group than in the non-TBM group (P < 0.05). The optimal cutoff values for the sensitivities and specificities of the test methods for diagnosing TBM with small samples of 10 cases of definite or probable TBM were as follows: ADA > 6.95 U/L, 70% and 81%; IL-12p40 > 52.04 pg/mL, 80% and 73%; IL-13 > 0.44 pg/mL, 90% and 47%; MIP-1α > 8.83 pg/mL, 80% and 62%; soluble PD-1 > 35.87 pg/mL, 80% and 63%; soluble PD-L1 > 24.19 pg/mL, 80% and 61%; CSF-MC ELISPOT > 13.5 spots/250,000 CSF-MC, 30% and 91%; and PBMC ELISPOT > 14 spots/250,000 PBMCs, 50% and 78%, respectively. Therefore, CSF IL-12p40, IL-13, MIP-1α, and soluble PD-1 and PD-L1 concentrations appear to be useful adjuncts for diagnosing TBM.
Correlates of response and outcomes with talimogene laherperpvec

Patients with in‐transit or limited cutaneous metastatic melanoma may benefit from intralesional injections with talimogene laherparepvec (TVEC), a modified oncolytic herpesvirus. However, its use in patients with adverse prognostic scores in a real‐life clinical setting has not been studied.
Genome‐wide characterization and developmental expression profiling of long non‐coding RNAs in Sogatella furcifera

The genome‐wide characterization of long non‐coding RNA (lncRNA) in insects demonstrates their importance in fundamental biological processes. Essentially, an in‐depth understanding of the functional repertoire of lncRNA in insects is pivotal to insect resources utilization and sustainable pest control. Using a custom bioinformatics pipeline, we identified 1861 lncRNAs encoded by 1852 loci in the Sogatella furcifera genome. We profiled lncRNA expression in different developmental stages and observed that the expression of lncRNAs is more highly temporally restricted compared to protein‐coding genes. More up‐regulated Sogatella furcifera lncRNA expressed in the embryo, 4th and 5th instars, suggesting that increased lncRNA levels may play a role in these developmental stages. We compared the relationship between the expression of Sogatella furcifera lncRNA and its nearest protein gene and found that lncRNAs were more correlated to their downstream coding neighbors on the opposite strand. Our genome‐wide profiling of lncRNAs in Sogatella furcifera identifies exciting candidates for characterization of lncRNAs, and also provides information on lncRNA regulation during insect development.
Olfactomedin-like 3: possible functions in embryonic development and tumorigenesis

Abstract Objective: Modern medical research has proven that human diseases are directly or indirectly related to genes. At the same time, genetic research has also brought updates to diagnostic techniques. Olfactomedin-like 3 (OLFML3) gene is a novel and clinically valuable gene. In order to better understand the role of OLFML3 in human diseases, we discuss and analyze the characteristics, function, and regulation mechanism of the OLFML3 gene in this review. Data sources: A comprehensive search in PubMed and ScienceDirect database for English up to March 2019, with the keywords of “Olfactomedin-like 3,” “Olfactomedin,” “extracellular matrix,” “Transforming Growth Factor β1,” “anoikis-resistance,” and “microRNA-155. ” Study selection: Careful review of all relevant literature, the references of the retrieved articles were also screened to search for potentially relevant papers. Results: OLFML3 is a secreted glycoprotein with 406 amino acid residues, belonging to the Olfactomedin (OLF) family. Due to the particularity of its structure and differential expression, OLFML3 has unique biological functions that could be distinct from other members in the OLF family. The currently known functions include embryonic development function and tumorigenesis. The regulation mechanism is still under investigation. It is directly related to many human diseases. Conclusions: OLFML3 is a multifunctional glycoprotein that is closely involved in embryonic development, tumor invasion, and metastasis. Unfortunately, current research on this important molecule is still very limited. Further investigations on the possible mechanism of OLFML3 biological functions and modulation will help us develop better diagnostics and treatments.
Health education strategies targeting maternal and child health

Abstract Background: Health education during pregnancy is important to improve maternal and children outcomes. However, the strategies must be specifically designed for each context and demographic characteristics. Our objective was identify health education strategies targeting pregnant women with the intention of improving results of pregnancy at an urban level. Methods: We conducted a scoping review of the literature to answer the question: “what health education strategies targeting pregnant women were reported by primary healthcare teams or the community promoting health in pregnancy, childbirth, postpartum and childhood? ” Potential eligible studies were selected using PubMed, Web of Science, LILACS and SciELO by 2 reviewers. Results: From a total of 3105 articles, 23 were deemed eligible. We identified 9 educational methodologies focusing on different outcomes of pregnancy, birth or maternal wellbeing. Conclusions: It is important that health education strategies continue after childbirth, independent of the strategy. All the strategies presented in this review are suitable for transfer with a moderate chance of success of implementation or improvement of current education methodologies. Further research is required on health education, including a higher number of patients.
Influence of Physical Education Teachers on Motivation, Embarrassment and the Intention of Being Physically Active During Adolescence

According to a WHO report (2018), more than 80% of adolescents do not do enough physical activity. Physical Education (PE) classes should be aimed at solving this problem. The present study aims to analyze the influence teachers have on motivation, embarrassment and intention to be physically active among their students. A total of 604 secondary school students participated in the study. Various statistical analyses were carried out to explain the causal relationships between the variables. The results revealed a positive relation between the autonomy support and the satisfaction of basic psychological needs (BPN), and a negative relation with the frustration of BPN. In contrast, perceived control revealed a positive relation with frustration of BPN, and a negative relation with the satisfaction of BPN. Satisfaction of BPN was negatively related to embarrassment and positively related to self-determined motivation. On the other hand, frustration of BPN was positively related to embarrassment and negatively with self-determined motivation. Embarrassment was negatively related to self-determined motivation, and the latter was positively related to intention to be physically active. Indeed, the study demonstrates the influence and the importance of PE teachers and of the motivational and emotional processes of adolescents during PE classes and the role they play in acquiring the habits of an active lifestyle.
A Diagnostic Procedure for Detecting Outliers in Linear State–Space Models

Abstract Outliers can be more problematic in longitudinal data than in independent observations due to the correlated nature of such data. It is common practice to discard outliers as they are typically regarded as a nuisance or an aberration in the data. However, outliers can also convey meaningful information concerning potential model misspecification, and ways to modify and improve the model. Moreover, outliers that occur among the latent variables (innovative outliers) have distinct characteristics compared to those impacting the observed variables (additive outliers), and are best evaluated with different test statistics and detection procedures. We demonstrate and evaluate the performance of an outlier detection approach for multi-subject state-space models in a Monte Carlo simulation study, with corresponding adaptations to improve power and reduce false detection rates. Furthermore, we demonstrate the empirical utility of the proposed approach using data from an ecological momentary assessment study of emotion regulation together with an open-source software implementation of the procedures.
The prevalence of eustachian tube dysfunction symptoms in temporomandibular joint disorder patients

Ear fullness and pressure is a common complaint seen in otolaryngology clinics and frequently is attributed to eustachian tube dysfunction (ETD). In addition to traditional tympanometry and physical examination, the seven‐item Eustachian Tube Dysfunction Questionnaire (ETDQ‐7) has recently been used to aid in the diagnosis of ETD and to assess its severity. Temporomandibular joint disorder (TMJD) is a common condition that causes similar symptoms to ETD and has been recognized as a potential confounding condition in patients presenting with ETD symptoms. We sought to determine the cross‐sectional prevalence of ETD symptoms in patients with TMJD using the ETDQ‐7.