Miracle-dz/UniFAR-FTUs huggingface dataset:
A general population twin study of the CBCL/6-18 DSM-oriented scales.

OBJECTIVE To explore the contributions of genetic and environmental influences to individual variation and covariation of the Child Behavior Checklist (CBCL) DSM-oriented scales (DOS) originally proposed by Achenbach and associates in 2001. METHOD A classic twin study of 398 twin pairs ages 8 to 17 years belonging to the population-based Italian Twin Registry, assessed by parents using the CBCL for Ages 6 to 18 (CBCL/6-18). RESULTS Univariate analyses showed that compared with the classic CBCL/6-18 empirical subscales, the DOS have higher heritability (lowest 0.54 for Anxiety Problems, highest 0.71 for Conduct Problems) and simpler causal structure in that the phenotypic variance was satisfactorily explained by additive genetic and unique environmental factors only. Multivariate analyses showed that the causes of phenotypic correlation among the different DOS can be attributed to one common genetic factor and to two idiosyncratic environmental factors, each loading differently on the Internalizing (Anxiety and Affective Problems) and the Externalizing (Attention-Deficit/Hyperactivity, Oppositional Defiant, and Conduct Problems) CBCL/6-18 DOS. CONCLUSIONS Several common risk factors of both genetic and environmental nature can simultaneously affect a child's proneness to develop the psychopathological signs and symptoms captured by the CBCL/6-18 DOS.
Yüksek teknolojili ürün ihracatı üzerinde doğrudan yabancı sermaye yatırımları ve dışa açıklığın etkisi: Gelişmekte olan ülkelerde panel veri analizi

Gelismekte olan ulkelerin ekonomik kalkinmalarinda yuksek teknolojili urun ihracati onemli bir faktordur. Bu yuzden yuksek teknolojili urun ihracati, ozellikle gelismekte olan ulkelerin ekonomik buyumelerini artirmada buyuk onem arz etmektedir. Yuksek teknolojili urun ihracati son donemlerde ekonomi cevrelerinde icerdigi yuksek katma degerden dolayi buyumenin belirleyicilerinden biri olarak kabul edilmektedir. Literaturde yuksek teknolojili urun ihracatini etkileyen pek cok faktor bulunmaktadir. Bu calismada 2000-2012 doneminde gelismekte olan 12 ulkede dogrudan yabanci sermaye yatirimlari ve disa acikligin yuksek teknolojili urun ihracatini uzerindeki etkisi panel veri analizi yontemi ile arastirilmistir. Uygulama sonucunda, dogrudan yabanci sermaye yatirimlari ve disa acikliginin yuksek teknolojili urun ihracatini pozitif etkiledigi gorulmustur. Calismada elde edilen ampirik bulgular cercevesinde gelismekte olan ulkelere yonelik politika onerileri sunulmustur.
Vector Control, Pest Management, Resistance, Repellents A New In Vitro Bioassay System for the Discovery and Quantitative Evaluation of Mosquito Repellents

Mosquitoes vector many pathogens that cause human diseases. Repellents play a significant role in reducing the risk of these diseases by preventing mosquito bites. In this paper, we are reporting an Ali and Khan (A & K), large cage in vitro bioassay system that can effectively be used to measure repellency of compounds against mosquitoes. The system uses temperature as a landing and feeding stimulus, and collagen as a feeding substrate. The minimum effective dose (MED) of DEET (N, N-diethyl-meta-toluamide; 19.3 mg/cm) against Aedes aegypti (L.) in a 30-cm treatment area from the A & K bioassay falls in the upper range of the in vivo, cloth patch bioassay (6–23 mg/cm). Undecanoic acid and geranic acid, with MED values of 3.6 and 7.5 mg/cm, respectively, in the A & K bioassay were active at 5.5–6.6 times lower dose than that in the in vivo bioassay. Thymol and methyl eugenol with MED values of 11.1 and 10.9 mg/cm, respectively, were active at 3–4 times lower dose than that in the in vivo bioassay, whereas (-)-trans-p-Menthane-3,8 diol with MED value of 32.3 mg/cm was active at 1.3 times lower dose. Comparisons between 12-cm and 30-cm treatment areas, with similar concentration per unit area in the A & K bioassay, indicated that the MED values at 30 cm were 1–2 times higher. In addition to its use to identify the repellent properties of new products, the A & K bioassay can generate useful data on promising repellents to make in vivo testing and field evaluation decisions.
Semen samples showing an increased rate of spermatozoa with imprinting errors have a negligible effect in the outcome of assisted reproduction techniques

The topic of imprinting defects present in the sperm of infertile patients has been addressed by several reports in the last few years. However, whether methylation abnormalities at one or few CpGs within an imprinted locus are pathological is a matter of debate. Moreover, whether imprinting anomalies in sperm could interfere with fertility treatment outcomes is still unknown. In this report we analyze the sperm DNA methylation profile of H19-ICR, KvDMR, SNRPN-ICR, IG-DMR and MEG3-DMR by pyrosequencing in 107 infertile men series and a control population of 30 proven fertile males. DNA methylation was statistically evaluated from two points of view: first, the methylation of each CpG was analyzed in the control population and the mean, standard deviation and range were determined and compared with infertile population data; second, in order to define altered methylation patterns for each region, a hierarchical cluster analysis was performed by which individuals were grouped in different clusters according to the degree of similarity of their methylation pattern. Two pieces of data supported the results obtained in the multi-variate analysis: the classification of the vast majority of control individuals in clusters with normal methylation patterns and the significant differences in methylation levels found between individuals within the normal and abnormal clusters. Individuals included in normal and abnormal methylation clusters were compared according to seminal parameters as well as to the outcome of assisted reproduction.
Musclin is an activity-stimulated myokine that enhances physical endurance

Significance Skeletal muscle is increasingly recognized as a secretory organ. Revealing the identity and function of myokines can improve our understanding of skeletal muscle function under sedentary or exercise conditions, as well as its coordination with other organs, tissues, and overall body metabolism. This study identifies musclin as an exercise-responsive myokine critical for skeletal muscle adaptation to physical activity. We develop a musclin-encoding gene (Ostn) knockout mouse, which allows us to determine a previously unrecognized physiologic function of musclin in regulation of skeletal muscle mitochondrial biogenesis and physical endurance. The demonstrated molecular mechanism for musclin-dependent skeletal muscle adaptation to exercise also transforms the perspective on natriuretic peptide signaling, particularly as it relates to physical activity and exercise-induced remodeling in different tissues. Exercise remains the most effective way to promote physical and metabolic wellbeing, but molecular mechanisms underlying exercise tolerance and its plasticity are only partially understood. In this study we identify musclin—a peptide with high homology to natriuretic peptides (NP)—as an exercise-responsive myokine that acts to enhance exercise capacity in mice. We use human primary myoblast culture and in vivo murine models to establish that the activity-related production of musclin is driven by Ca2+-dependent activation of Akt1 and the release of musclin-encoding gene (Ostn) transcription from forkhead box O1 transcription factor inhibition. Disruption of Ostn and elimination of musclin secretion in mice results in reduced exercise tolerance that can be rescued by treatment with recombinant musclin. Reduced exercise capacity in mice with disrupted musclin signaling is associated with a trend toward lower levels of plasma atrial NP (ANP) and significantly smaller levels of cyclic guanosine monophosphate (cGMP) and peroxisome proliferator-activated receptor gamma coactivator 1-α in skeletal muscles after exposure to exercise. Furthermore, in agreement with the established musclin ability to interact with NP clearance receptors, but not with NP guanyl cyclase-coupled signaling receptors, we demonstrate that musclin enhances cGMP production in cultured myoblasts only when applied together with ANP. Elimination of the activity-related musclin-dependent boost of ANP/cGMP signaling results in significantly lower maximum aerobic capacity, mitochondrial protein content, respiratory complex protein expression, and succinate dehydrogenase activity in skeletal muscles. Together, these data indicate that musclin enhances physical endurance by promoting mitochondrial biogenesis.
Spinal Clonidine Fails to Provide Surgical Anesthesia for Transurethral Resection of Prostate: A Dose-Finding Pilot Study

Background and Objectives This study was designed to determine whether subarachnoid clonidine administration alone results in surgical anesthesia for transurethral resection of the prostate. Methods Blood pressure, heart rate, sedation, and sensory and motor blocks were assessed in 12 patients before and after lumbar subarachnoid injection of increasing doses of clonidine (three patients each received 75, 150, 300, and 450 μg doses). General anesthesia was induced at the request of the patient or surgeon, if conditions were unsatisfactory. Results Clonidine resulted in marked sedation within a mean of 19 minutes of spinal injection, and no motor block was observed. There was a 25% (range, 0-45%) reduction in mean arterial blood pressure. Although endoscopy was tolerated in all cases, general anesthesia was required when resection began, except in two patients who received 300 and 450 μg of clonidine, respectively. Postoperative analgesic requirements showed wide interindividual variability (mean, 6 hours; range 2-12 hours). Conclusions Subarachnoid clonidine cannot be reliably used as the sole agent for spinal anesthesia, since general anesthesia is often required or deep sedation occurs. Increasing doses of clonidine do not prolong postoperative analgesia. Thus, clonidine could be used as a spinal analgesic but not as a spinal anesthetic.
Protein Turnover Quantification in a Multilabeling Approach: From Data Calculation to Evaluation*

Liquid chromatography coupled to tandem mass spectrometry in combination with stable-isotope labeling is an established and widely spread method to measure gene expression on the protein level. However, it is often not considered that two opposing processes are responsible for the amount of a protein in a cell—the synthesis as well as the degradation. With this work, we provide an integrative, high-throughput method—from the experimental setup to the bioinformatics analysis—to measure synthesis and degradation rates of an organism's proteome. Applicability of the approach is demonstrated with an investigation of heat shock response, a well-understood regulatory mechanism in bacteria, on the biotechnologically relevant Corynebacterium glutamicum. Utilizing a multilabeling approach using both heavy stable nitrogen as well as carbon isotopes cells are metabolically labeled in a pulse-chase experiment to trace the labels' incorporation in newly synthesized proteins and its loss during protein degradation. Our work aims not only at the calculation of protein turnover rates but also at their statistical evaluation, including variance and hierarchical cluster analysis using the rich internet application QuPE.
Women’s Exhaustion and Coronary Artery Atherosclerosis Progression: The Stockholm Female Coronary Angiography Study

Objective Vital exhaustion (VE) has been associated with incident and recurrent cardiac events. The present study investigated the impact of VE on coronary atherosclerosis progression for 3 years. We further aimed to detect the relative importance of the VE subcomponents, fatigue, and depressed mood. Methods 103 women (age range, 30–65 years) who had experienced an acute coronary event underwent quantitative coronary angiography at baseline and again after 3 years. VE and subcomponents were assessed using the Maastricht Questionnaire. Results VE correlated significantly with coronary artery diameter change for 3 years (r = −0.239, p = .015). When analyzed in quartiles, women of the highest VE level showed the most pronounced coronary artery luminal diameter narrowing (mean = 0.21 mm, 95% confidence interval [CI] = 0.15–0.27), women in the third quartile were intermediate (mean = 0.11 mm, 95% CI = 0.05–0.17), and women within the two lower quartiles showed no significant change. High levels of the depressed mood and fatigue subscales were also associated with coronary artery diameter narrowing (mean = 0.19 mm, 95% CI = 0.12–0.26, p = .003; and mean = 0.17 mm, 95% CI = 0.08–0.26, p = .03, respectively). However, the associations were attenuated when both variables were entered into the model simultaneously: 0.17 mm (95% CI = 0.09–0.25, p = .05) and 0.14 mm (95% CI = 0.03–0.25, p = .67), respectively. Conclusions VE was associated with accelerated coronary atherosclerosis progression in relatively young women who had experienced an acute coronary event. This association was mainly driven by depressed mood.
Efficacy and Safety of a Pharmaco-Invasive Strategy With Half-Dose Alteplase Versus Primary Angioplasty in ST-Segment–Elevation Myocardial Infarction: EARLY-MYO Trial (Early Routine Catheterization After Alteplase Fibrinolysis Versus Primary PCI in Acute ST-Segment–Elevation Myocardial Infarction)

Background: Timely primary percutaneous coronary intervention (PPCI) cannot be offered to all patients with ST-segment–elevation myocardial infarction (STEMI). Pharmaco-invasive (PhI) strategy has been proposed as a valuable alternative for eligible patients with STEMI. We conducted a randomized study to compare the efficacy and safety of a PhI strategy with half-dose fibrinolytic regimen versus PPCI in patients with STEMI. Methods: The EARLY-MYO trial (Early Routine Catheterization After Alteplase Fibrinolysis Versus Primary PCI in Acute ST-Segment–Elevation Myocardial Infarction) was an investigator-initiated, prospective, multicenter, randomized, noninferiority trial comparing a PhI strategy with half-dose alteplase versus PPCI in patients with STEMI 18 to 75 years of age presenting ⩽6 hours after symptom onset but with an expected PCI-related delay. The primary end point of the study was complete epicardial and myocardial reperfusion after PCI, defined as thrombolysis in myocardial infarction flow grade 3, thrombolysis in myocardial infarction myocardial perfusion grade 3, and ST-segment resolution ≥70%. We also measured infarct size and left ventricular ejection fraction with cardiac magnetic resonance and recorded 30-day clinical and safety outcomes. Results: A total of 344 patients from 7 centers were randomized to PhI (n=171) or PPCI (n=173). PhI was noninferior (and even superior) to PPCI for the primary end point (34.2% versus 22.8%, P noninferiority<0.05, Psuperiority=0.022), with no significant differences in the frequency of the individual components of the combined end point: thrombolysis in myocardial infarction flow 3 (91.3% versus 89.2%, P=0.580), thrombolysis in myocardial infarction myocardial perfusion grade 3 (65.8% versus 62.9%, P=0.730), and ST-segment resolution ≥70% (50.9% versus 45.5%, P=0.377). Infarct size (23.3%±11.3% versus 25.8%±13.7%, P=0.101) and left ventricular ejection fraction (52.2%±11.0% versus 51.4%±12.0%, P=0.562) were similar in both groups. No significant differences occurred in 30-day rates of total death (0.6% versus 1.2%, P=1.0), reinfarction (0.6% versus 0.6%, P=1.0), heart failure (13.5% versus 16.2%, P=0.545), major bleeding events (0.6% versus 0%, P=0.497), or intracranial hemorrhage (0% versus 0%), but minor bleeding (26.9% versus 11.0%, P<0.001) was observed more often in the PhI group. Conclusions: For patients with STEMI presenting ⩽6 hours after symptom onset and with an expected PCI-related delay, a PhI strategy with half-dose alteplase and timely PCI offers more complete epicardial and myocardial reperfusion when compared with PPCI. Adequately powered trials with this reperfusion strategy to assess clinical and safety outcomes are warranted. Clinical Trial Registration: URL: https://www.clinicaltrials. gov. Unique identifier: NCT01930682.
Exploiting Video Quality Information in Rate Adaptation for HTTP-Based Video Streaming

This paper explores how video quality information can be exploited by HTTP-based adaptive streaming (HAS) clients in their rate adaptation schemes. We first present an idealized combinatorial optimization formulation of the quality-aware rate adaptation problem and its corresponding solution. A few design principles are then introduced to arrive at a practical and robust rate adaptation scheme in the presence of real-world uncertainties (e.g., inaccuracy in bandwidth estimation, unforeseen changes in future video contents). Results from testbed-based experiments verify that by exploiting video quality information, our proposed quality-aware rate adaptation scheme significantly outperforms conventional rate-based clients in various contention-free and multi-client contention scenarios.
Shielding effectiveness of non-woven carbon fibre sheets: Modelling the microstructure

This paper describes work undertaken to understand how the structure of a nonwoven carbon fibre material determines its shielding effectiveness, including the effects of fibre orientation, and contact resistance. In order to facilitate understanding of the material behaviour, software has been written to generate Monte Carlo Models (MCMs) of the material structure. The results of our MCMs are compared with measurements and some empirical expressions.
Does Age of Onset in Essential Tremor Have a Bimodal Distribution? Data from a Tertiary Referral Setting and a Population-Based Study

Background/Aims: The distribution of age of onset of essential tremor (ET) is unclear, with discrepancies in the literature. Some data suggest a bimodal distribution and other data 1 late-life peak. We studied age of ET onset in 2 distinct settings: a population-based study and a tertiary referral center. Methods: Age of onset data were collected. Results: In the population, there was only a small peak at the age of ≤30 years (14.1% of cases) but a clear peak in later life (85.9% of cases). In the tertiary referral center, a bimodal distribution was apparent with 1 large peak (42.2% of cases) at the age of ≤40 years and the second large peak (57.8% of cases) in later life. Familial cases accounted for only 52.6% of young-onset cases from the population, yet 82.7% from the tertiary center. Discussion: In the population-based study, a peak in later life was clearly present but a young-onset peak was barely discernable, comprising few cases. By contrast, in a tertiary referral center, age of onset was clearly bimodal. While age of ET onset is often said to be bimodal, this may be due to the preferential referral to tertiary centers of patients with young-onset, familial ET.
Hemispheric asymmetries on computed tomographic scans in schizophrenia and mania. A controlled study and a critical review.

A major reason for reassessing hemispheric asymmetries in schizophrenics by computed tomography is the methodologic shortcomings of previously published measurement techniques. We used completely blind measurements, multiple measurements performed by two independent examiners of each region of the brain, and an SE of measurement with a confidence level of P less than . 01 to define significant asymmetry. The frequency of reversed occipital asymmetry was significantly higher in the 36 schizophrenic than in the 18 manic right-handed male patients. Furthermore, when all of the previously published techniques were applied to these patients, the frequency of such a reversal was consistently higher in the schizophrenic than in the manic group. Further investigation of hemispheric asymmetries in schizophrenics is warranted.
Methicillin-resistant Staphylococcus aureus susceptibility testing with Abbott MS-2 system

The antimicrobial susceptibilities of 100 methicillin=resistant Staphylococcus aureus strains were concurrently determined by the Abbott MS-2 System and by the standard disk diffusion method. Agreement between the two methods was 94% or greater for all of the antibiotics tested except for methicillin and gentamicin. This study indicates that the Abbott MS-2 cannot be relied upon for detection of methicillin resistance in clinical S. aureus isolates.
"Difficult patients" in mental health care: a review.

OBJECTIVE This article provides an overview of what is known about "difficult patients" in mental health care. It aims to answer three main questions: What are the defining characteristics of difficult patients, how is the difficulty explained, and which treatment strategies are available? METHODS A search of the MEDLINE, PsycINFO, and CINAHL databases was conducted for articles published between 1979 and 2004 that had "difficult patients" as their main topic, resulting in 94 eligible articles. RESULTS Characteristics of difficult patients in psychiatric care were consistent across several studies. Explanations for these difficulties widely varied: individual, interpersonal, and social factors were identified. Interventions were described in little detail and offered relatively few specific guidelines for daily practice, although some general principles are summarized. Difficult patients are classified into three subgroups, and some prevailing discourses on difficult patients in mental health care are discussed. CONCLUSIONS Treatment strategies or settings exist for two of the three groups of difficult patients-those with severe mental illness (unwilling care avoiders) and those with the least severe psychiatric symptoms but the most difficult behaviors (demanding care claimers). The remaining group (ambivalent care seekers), which consists of those who seek care but exhibit ambivalent behaviors that could be interpreted as both difficult and ill, is not supported sufficiently by effective treatment strategies. Further development and research into effective interventions is suggested for this group.
Interspecific variation in the allelopathic potential of the family Myrtaceae

Allelopathy is a type of biotic interference wherein a plant releases bioactive metabolites into an environment, thereby affecting the adjacent biota. Stressful environments stimulate the production of these metabolites. The present study tests the novel weapons hypothesis, which postulates that species belonging to the same genus and from the same environment have similar allelopathic effects. The aim of this study was to assess the allelopathic effects that the aqueous leaf extracts of 15 species belonging to five genera of the Myrtaceae family have on the seed germination and initial seedling growth of lettuce (Lactuca sativa L.), tomato (Solanum lycopersicum L.) and onion (Allium cepa L.). Germination rates, average germination times, informational entropy of germination and allelopathic effects, as quantified with a response index, were calculated. A taxonomic distance matrix based on Gower dissimilarity and a Euclidean distance matrix were constructed. The results revealed that all extracts from donor species significantly increased average germination time or reduced the germination rate of eudicotyledonous plant species. The only extracts that showed no effect on monocotyledonous seeds were those of Campomanesia pubescens O. Berg and Psidium cinereum Mart. We conclude that eudicotyledonous and monocotyledonous plants were both significantly affected by the presence of all extracts tested. Our results make it clear that each species behaves distinctly in relation to allelopathic activity, with no apparent grouping by genus or subtribe. Therefore, the hypothesis was rejected, because plants from the same environment and with taxonomic proximity do not necessarily display similar production of secondary metabolites.