Miracle-dz/UniFAR-FTUs huggingface dataset:
[Terson syndrome: a frequently missed ophthalmologic complication in subarachnoid hemorrhage].

The syndrome of intra-vitreous bleeding in association with subarachnoid hemorrhage (SAH) was first described by the French ophthalmologist Albert Terson. In the last 10 years, 31 articles describing 202 cases of Terson's syndrome (TS) were published. Only 3 out of the 31 were printed in non-ophthalmological journals. The findings of our prospective study underline the fact that too little attention is paid to TS in the early treatment of patients with SAH. Between 1/95 and 8/97, 89 patients with spontaneous SAH (7% of all admissions) were transferred to our hospital for post acute phase rehabilitation. Out of these, 13 patients (19 eyes) could be diagnosed with TS. This corresponds to an incidence of 14.6% of all patients with SAH (previous studies: 2-27%). However, only one patient had been correctly diagnosed with TS in the referring clinic. Early recognition of TS is of high importance since diminuation of visual acuity even to functional blindness, complicated in the bilateral case, can hamper the rehabilitative process considerably. Moreover, complications can lead to significant and irreversible damage, i.e. proliferative vitreo-retinopathy (PVR), retinal breaks, traction amotio, and cataract. Suspicion of TS is raised in either cooperative patients complaining of compromised visual acuity or in patients where funduscopy shows vitreous opacity. According to our results, visual evoked potentials (VEP) have only a limited role in diagnosis because of their low sensitivity. Not infrequently, however, VEP may point to accompanying optic nerve atrophy, thereby suggesting conservative treatment. Absolute indications for surgical interventions are PVR and its sequelae; relative indications are subjective visual impairment, impediment of rehabilitation, or lack of spontaneous resorption of the hemorrhage. The surgical procedure of choice is the pars plana vitrectomy (PPV). Rare complications of this operation are retinal damage, endophthalmitis, and reoccurrence of hemorrhage.
IDENTIFICATION OF BIOACTIVE COMPOUNDS FROM EGYPTIAN MULBERRY FRUITS AND THEIR USES IN IMPROVEMENT THE QUALITY OF SOME FOODS

This work was carried out to study the chemical and nutritional properties of some egyptian mulberry species. White , black mulberry, goldenberry and strawberry fruits were analyzed for their proximate chemical composition, phenolic compounds, flavonoids contents, vitamins, some reducing and non reducing sugars, beta-carotenoids and anthocyanin to evaluate their importance in human nutrition. The results showed that white mulberry contained 79.34% moisture, 12.98% protein, 9.03% ether extract, 6.36% ash, 8.32% crude fiber and 63.31% carbohydrates, while, the black mulberry contained 76.45% moisture, 10.85% protein, 7.21% ether extract, 4.79% ash, 5.45% crude fiber and 71.7% carbohydrates. On the other hand, goldenberry contained 77.78% moisture, 9.16% protein, 9.95% ether extract, 5.44% ash, 16.32% crude fiber and 59.13% carbohydrates. It could be noticed that strawberry recorded 90.87% moisture, 7.65% protein, 3.74% ether extract, 3.48% ash, 10.32% crude fiber and 74.81% carbohydrates. High concentrations of phenolic compounds and flavonoids from this egyptian mulberry species were found. It can be concluded that the consumption of white, black mulberry, goldenberry and strawberry in different combinations could provide a reasonable daily recommended amount of essential nutrients for maintenance of healthy life and normal body functioning. The organoleptic evaluation of juices and jams prepared by mixing strawberry with white, black mulberry and goldenberry at three ratios 25, 50 and 75% was carried out.
The effect of heartburn and acid reflux on the severity of nausea and vomiting of pregnancy.

BACKGROUND Heartburn (HB) and acid reflux (RF) in the nonpregnant population can cause nausea and vomiting; therefore, it is plausible that in women with nausea and vomiting of pregnancy (NVP), HB/RF may increase the severity of symptoms. OBJECTIVE To determine whether HB/RF during pregnancy contribute to increased severity of NVP. METHODS A prospectively collected cohort of women who were experiencing NVP and HB, RF or both (n=194) was studied. The Pregnancy-Unique Quantification of Emesis and Nausea (PUQE) scale and its Well-being scale was used to compare the severity of the study cohort's symptoms. This cohort was compared with a group of women experiencing NVP but no HB/RF (n=188). Multiple linear regression was used to control for the effects of confounding factors. RESULTS Women with HB/RF reported higher PUQE scores (9.6+/-2.6) compared with controls (8.9+/-2.6) (P=0.02). Similarly, Well-being scores for women experiencing HB/RF were lower (4.3+/-2.1) compared with controls (4.9+/-2.0) (P=0.01). Multiple linear regression analysis demonstrated that increased PUQE scores (P=0.003) and decreased Well-being scores (P=0.005) were due to the presence of HB/RF as opposed to confounding factors such as pre-existing gastrointestinal conditions/symptoms, hyperemesis gravidarum in previous pregnancies and comorbidities. CONCLUSION The present cohort study is the first to demonstrate that HB/RF are associated with increased severity of NVP. Managing HB/RF may improve the severity of NVP.
A Solution to the Measurement Problem in the Idiographic Approach Using Computer Adaptive Practicing

Molenaar’s manifesto on psychology as idiographic science (Molenaar, 2004) brought the N=1 times series perspective firmly to the attention of developmental scientists. The rich intraindividual variation in complex developmental processes requires the study of these processes at the level of the individual. Yet, the idiographic approach is all but easy in practical research. One major limitation is the collection of short interval times series of high quality data on developmental processes. In this paper, we present a novel measurement approach to this problem. We developed an online practice and monitoring system which is now used by thousands of Dutch primary school children on a daily or weekly basis, providing a new window on cognitive development. We will introduce the origin of this new instrument, called Math Garden, explain its setup, and present and discuss ways to analyze children’s individual developmental pathways.
The sponge-tipped catheter--a modification of the open end catheter for recording of myometrial activity in vivo.

Many techniques, especially the intra-uterine rubber balloon, have been used for the recording ofuterine contractions in the pregnant and non-pregnant woman. The size of the balloon and its tension, however, greatly influence the results, as Reynolds (1949) has pointed out. Furthermore, it is difficult to maintain exactly the same balloon volume throughout several hours' recording. Some years ago Hendricks (1964) introduced the `open end' catheter technique which is rather simple: a thin, fluid-filled polyethylene catheter is introduced into the cavity of the non-pregnant uterus, and its outer end is connected to a recording system. The fluid surface at the inner tip of the catheter acts as a pressure membrane which transmits the pressure in the slit between the anterior and posterior uterine wall to the fluid within the catheter and thence to the recording instrument. In trained hands this technique works very well and it has been successfully used by Hendricks (1964, 1965, 1966), Bengtsson & Theobald (1966), Bengtsson & Moawad (1966, 1967), Moawad & Bengtsson (1967), Cibils (1967) and Coutinho (1967).
Generating Realistic Network Traffic for Security Experiments

This paper reports results of an effort to develop a test environment in which ¿live¿ attack-free background traffic reflects the characteristics of the network to be defended. The expectation is that new intrusion detection techniques can be better evaluated (and tuned), in such a background, against inserted attacks and no others. Based on analysis of traffic captured from an example network in 2003, we determine models appropriate for the major Internet protocols present and compare these with previously obtained results. We describe the traffic modeling, and we describe an approach for generating realistic attack-free traffic (that is statistically similar to the captured traffic) in a test environment.
Parental stress, marital satisfaction and responsiveness to children: A comparison between mothers of children with and without inborn impairment

The birth of a child with chronic illness or disability has a major impact on the family as a whole Ž . and on the mother in particular Phillips, 1991 . Most of the research and clinical reports in this area have focused on parental reaction to the crisis and the possible consequences for the entire family unit. In many cases the child’s chronic illness or Ž disability has an impact on marital life Walker et . al., 1992; Gibson, 1995; Davis et al., 1998 . AccordŽ . ing to Featherston 1980 , parents of children with disabilities or chronic illness have an 8 to 1 ratio of divorce as compared to parents of healthy children. Ž . In this context, Broom 1994 found a significant relationship between marital satisfaction and the providing of appropriate care for the sick child. Ž . Heckel and Ruble 1992 suggest that unrealistic parental expectations about the child’s development could be responsible for the change in quality Ž . of marriage. However, Kazak and Marvin 1984 cast doubt on whether the stress related to a child’s disability has a direct impact on the couple’s quality of marriage. They report that there are cases where the child’s serious medical condition had a positive effect and contributed to greater harmony and a sense of mutual affection between the partners. Mothers are perceived as the core caregivers for Ž . their young children. As Caldwell 1970 assumes in the Home Observation for Measurement of the Environment, parenting is the ability to provide a child with a growing physical and emotional environment. In the case of a child with disability or chronic illness, there is a debate in the literature as
Ubiquitin-specific Peptidase 8 (USP8) Regulates Endosomal Trafficking of the Epithelial Na+ Channel*

Background: Ubiquitination controls trafficking of the epithelial Na+ channel (ENaC) in the endocytic pathway. Results: USP8 deubiquitinated ENaC and blocked its degradation, resulting in increased ENaC abundance at the cell surface and increased current. Conclusion: USP8 regulates endocytic sorting of ENaC. Significance: Regulation of the ubiquitination state of ENaC is important for Na+ homeostasis and blood pressure control. Ubiquitination plays a key role in trafficking of the epithelial Na+ channel (ENaC). Previous work indicated that ubiquitination enhances ENaC endocytosis and sorting to lysosomes for degradation. Moreover, a defect in ubiquitination causes Liddle syndrome, an inherited form of hypertension. In this work, we identified a role for USP8 in the control of ENaC ubiquitination and trafficking. USP8 increased ENaC current in Xenopus oocytes and collecting duct epithelia and enhanced ENaC abundance at the cell surface in HEK 293 cells. This resulted from altered endocytic sorting; USP8 abolished ENaC degradation in the endocytic pathway, but it had no effect on ENaC endocytosis. USP8 interacted with ENaC, as detected by co-immunoprecipitation, and it deubiquitinated ENaC. Consistent with a functional role for deubiquitination, mutation of the cytoplasmic lysines of ENaC reduced the effect of USP8 on ENaC cell surface abundance. In contrast to USP8, USP2-45 increased ENaC surface abundance by reducing endocytosis but not degradation. Thus, USP8 and USP2-45 selectively modulate ENaC trafficking at different steps in the endocytic pathway. Together with previous work, the data indicate that the ubiquitination state of ENaC is critical for the regulation of epithelial Na+ absorption.
Learning from new perspectives: Using sparse data and multiple views to predict cancer progression and treatment

Author(s): Graim, Kiley Schmidt | Advisor(s): Stuart, Josh M | Abstract: Advancements in sequencing technology have led to an influx of cancer genomics data, transforming cancer research into a field limited by data interpretation rather than acquisition. Machine learning methods that can make use of this wealth of data are desperately needed. Similarly, patient stratification is a critical task in cancer diagnosis and treatment. While stratification approaches using various biomarkers for patient-to-patient comparisons have been successful in elucidating previously unseen subtypes, the potential of many other sparse but rich genotype and phenotype data (e.g. tumor images) remains untapped. To this end, I present two methods. The first uses social network analysis techniques to extract subtypes from sparse data. The second is a semi-supervised multiview learning framework that integrates both prior knowledge and a variety of genomic data to predict outcomes in cancer. Crucially, this method accommodates samples for which we have different data types, paving the way for integration of data from past studies.I apply these methods to several cancer datasets. Of note, I show that TCGA--defined molecular subtypes of glioblastoma are independent of both tumor location and volume, and that both the imaging and genomic data provide important perspectives of the disease. Analysis of a large drug sensitivity database identifies an epigenetic effect from chromatin modifiers that lends sensitivity to Panobinostat. Multiview learning, the second method I developed, also outperforms other methods in predicting sensitivity in all of the study drugs. In this dissertation I begin with unsupervised single--platform analysis, then combine multiple platforms, and finally analyze many data platforms using semi--supervised analysis.
20 Multi-Component Vaccines for Suppression of Type 1 Diabetes

Many individual therapeutic strategies involving oral delivery of diabetes autoantigens such as insulin and GAD have been shown to provide partial short term suppression of organ specific type 1 diabetes autoimmunity (Weiner et al. 1991; Zhang et al. 1991; Nakayama et al. 2005). However, few individual therapies have been able to demonstrate effective, safe and persistent protection against type 1 diabetes onset or progression (Hutchings and Cooke 1998). More recently, combinatorial therapeutic strategies that incorporate immunostimulatory molecules such as the cholera toxin B subunit (CTB), linked to a diabetes autoantigen (eg. insulin or GAD), were shown to substantially enhance immune suppression of juvenile (Type 1) diabetes autoimmunity to provide more effective, safe and sustainable disease prevention (Arakawa et al. 1998; Denes et al. 2006). Combinatorial vaccines involving oral delivery of the cholera toxin B subunit (CTB) linked to pancreatic autoantigens such as proinsulin and GAD delivered together were shown to provide additive enhancement of autoantigen mediated suppression of diabetes insulitis and hyperglycemia in contrast to inoculation of prediabetic mice with CTB::GAD or CTB::proinsulin alone (Arakawa, Chong, and Langridge 1998). Most recently, combinatorial DNA vaccination experiments including genes encoding CTB::GAD together with the immunosuppressive cytokine IL-10 were shown to completely suppress type 1 diabetes onset in non-obese prediabetic (NOD) mice (Denes et al. 2010). Thus, it is now clear that combinatorial vaccination strategies have the ability to completely prevent diabetes onset in genetically susceptible mammals. However, to harness and transfer this promising combinatorial vaccination strategy for effective and safe clinical therapy in type 1 diabetes patients, cellular and molecular mechanisms underlying multi-component vaccine stimulation of immunological tolerance must be defined. Initial steps required to attain this goal, will involve identification of mechanisms responsible for vaccine interactions with cells of the innate immune system i.e., dendritic cells (DCs), involved in the initial processing vaccine autoantigens. In order to understand how multi-component vaccines may function to prevent the development of chronic islet inflammation (insulitis) progressing to high blood sugar (hyperglycemia), it will be important to understand the nature of immune responses underlying type 1 diabetes disease onset. To accomplish this goal, hypotheses must be tested that suggest how adjuvant-autoantigen fusion proteins may enhance immunotolerance e.g.
Consistency in a marine algal‐grazer interaction over multiple scales

Coralline algae are conspicuous members of many marine assemblages, especially those characterized by intense grazing pressure. We explored whether articulated species, especially Corallina vancouveriensis, depend on grazing invertebrates to both establish and flourish in an exposed rocky intertidal setting, and whether this plant–grazer relationship varied over more than three orders of magnitude (≈100–>300,000 μm). Three experimental manipulations, supplemented by observations on recruitment, demonstrated that (i) C. vancouveriensis failed to recover rapidly from disturbed areas when grazers were experimentally excluded; (ii) recruitment occurred in the presence of grazers; (iii) increasing surface texture of molded surfaces enhanced coralline recruitment more when grazers were present; and (iv) settlement occurred predominately in microtopographical low areas of a molded surface, whereas a competitively superior fleshy red alga tended to recruit to high areas. These results confirm that coralline algal establishment and persistence are enhanced by grazers and reveal that this relationship is consistent over a range of biologically relevant scales.
LASTI F ACE : Matching and Blending Textured Faces

In this paper we present ELASTIFACE, a simple and versatile method for establishing correspondence between textured face models, either for the construction of a blend-shape facial rig or for the exploration of new characters by morphing between a set of input models. While there exists a wide variety of approaches for inter-surface mapping and mesh morphing, most techniques are not suitable for our application: They either require the insertion of additional vertices, are limited to topological planes or spheres, are restricted to near-isometric input meshes, and/or are algorithmically and computationally involved. In contrast, our method extends linear non-rigid registration techniques to allow for strongly varying input geometries. It is geometrically intuitive, simple to implement, computationally efficient, and robustly handles highly non-isometric input models. In order to match the requirements of other applications, such as recent perception studies, we further extend our geometric matching to the matching of input textures and morphing of geometries and rendering styles. CR Categories: I.3. 5 [Computer Graphics]: Computational Geometry and Object Modeling—Hierarchy and geometric transformations
Abdominal muscle size and symmetry at rest and during abdominal hollowing exercises in healthy control subjects

The symmetry of, and physical characteristics influencing, the thickness of the lateral abdominal muscles at rest and during abdominal exercises were examined in 57 healthy subjects (20 men, 37 women; aged 22–62 years). M‐mode ultrasound images were recorded from the abdominal muscles at rest and during abdominal hollowing exercises in hook‐lying. The fascial lines bordering the transvs. abdominis, obliquus internus and obliquus externus were digitized and the absolute thickness, relative thickness (% of total lateral thickness) and contraction ratio (thickness during hollowing/thickness at rest), as well as the asymmetry (difference between sides expressed as a percent of the smallest value for the two sides) for each of these parameters were determined for each muscle. Both at rest and during hollowing, obliquus internus was the thickest and transvs. abdominis the thinnest muscle. There were no significant differences between left and right sides for group mean thicknesses of any muscle; however, individual asymmetries were evident, with mean values for the different muscles ranging from 11% to 26%; asymmetry was much less for the contraction ratios (mean % side differences, 5–14% depending on muscle). Body mass was the most significant positive predictor of absolute muscle thickness, for all muscles at rest and during hollowing, accounting for 30–44% variance. Body mass index explained 20–30% variance in transvs. abdominis contraction ratio (negative relationship). The influence of these confounders must be considered in comparative studies of healthy controls and back pain patients, unless groups are very carefully matched. Asymmetries observed in patients should be interpreted with caution, as they are also common in healthy subjects.
Relationship of Job Stressors to Job Performance: Linear or an Inverted-U?

This study evaluated the potential positive effects of stressors on job performance by examining the shape of the relation between stressors and job performance. The 281 respondents were a demographically and organizationally heterogeneous group from the Detroit area, who were employed during the study. They were given four structured in-home interviews, approximately 6 weeks apart, over a period of 18 weeks. Interviews were also conducted with a significant other, nominated by each respondent from work life. Stressors examined were role ambiguity, role conflict, and job insecurity. Strains, also examined as potential stressors, were job dissatisfaction, anxiety, depression, and anger. Technical and social aspects of respondents' job performance were measured separately, as were absenteeism and tardiness. All zero-order Pearson correlations were either statistically significant and in predicted directions or essentially zero. All relationships were monotonic, suggesting that, for these stressors, their optimal amounts are generally zero. Results are discussed in terms of arousal and activation, information-processing, and expectancy theory.
Evidence for two distinct waves of epidermal ionocyte differentiation during medaka embryonic development

Background: The fish epidermis contains specific cells, or ionocytes, that are specialized in ion transport and contribute to the osmoregulatory function. Besides the zebrafish model, the medaka (Oryzias latipes) has recently emerged as an important model for osmoregulation studies because it possesses a particularly high adaptability to salinity changes. However, hindering the progress of research on embryonic ionocytes is the lack of a comprehensive view of their developmental dynamic. Results: Using EdU integrations and the foxi3 and NKA markers, we characterized the proliferating progenitors of ionocytes (here called ionoblastes) and we quantified them, along with ionocytes, during embryogenesis. While progenitors of the vitellin zone promptly differentiate in a synchronous manner, progenitors of the lateral zone differentiate progressively and asynchronously. Furthermore, we evidenced that nhe3 is expressed in differentiated ionocytes of both zones, whereas ecac, ncc, and gcm2 are strictly specific of the lateral zone. We also evidenced that the two zones are differentially regulated in distilled water and seawater. Conclusions: Our data led us to propose a model timeline, which provides evidence for the expansion of two successive and distinct populations of ionocytes. This model opens the way for new studies related to epidermal development, plasticity and osmoregulation ontogeny. Developmental Dynamics 244:888–902, 2015. © 2015 Wiley Periodicals, Inc.