Miracle-dz/UniFAR-FTUs huggingface dataset:
A novel cooperative caching scheme for Content Centric Mobile Ad Hoc Networks

Content Centric Mobile Ad-hoc NETwork (CCMANET) applies the advantages of Content Centric networking (CCN) into Mobile Ad Hoc Network(MANET) to overcome the drawbacks of low efficiency and unstable in transmission. Caching scheme is one of the key components of CCMANET. However, the caching scheme in CCMANET has not been well explored. In this paper, a novel cooperative caching scheme based on generalized dominating set and local content popularity for CCMANET is proposed. First, a virtual backbone in CCMANET is constructed by generalized dominating set to make the arbitrary topology become two-level hierarchy and a collaborative cache placement scheme between the two hierarchies is designed. Second, we propose a method of computing the local content popularity and a cache replacement scheme based on the local content popularity. Simulation results show that the proposed caching scheme can effectively reduces both path stretch value and server load, and improves the hit ratio compared with the existing caching schemes.
Discriminative Structure Learning of Bayesian Network Classifiers from Training Dataset and Testing Instance

Over recent decades, the rapid growth in data makes ever more urgent the quest for highly scalable Bayesian networks that have better classification performance and expressivity (that is, capacity to respectively describe dependence relationships between attributes in different situations). To reduce the search space of possible attribute orders, k-dependence Bayesian classifier (KDB) simply applies mutual information to sort attributes. This sorting strategy is very efficient but it neglects the conditional dependencies between attributes and is sub-optimal. In this paper, we propose a novel sorting strategy and extend KDB from a single restricted network to unrestricted ensemble networks, i.e., unrestricted Bayesian classifier (UKDB), in terms of Markov blanket analysis and target learning. Target learning is a framework that takes each unlabeled testing instance P as a target and builds a specific Bayesian model Bayesian network classifiers (BNC)P to complement BNCT learned from training data T. UKDB respectively introduced UKDBP and UKDBT to flexibly describe the change in dependence relationships for different testing instances and the robust dependence relationships implicated in training data. They both use UKDB as the base classifier by applying the same learning strategy while modeling different parts of the data space, thus they are complementary in nature. The extensive experimental results on the Wisconsin breast cancer database for case study and other 10 datasets by involving classifiers with different structure complexities, such as Naive Bayes (0-dependence), Tree augmented Naive Bayes (1-dependence) and KDB (arbitrary k-dependence), prove the effectiveness and robustness of the proposed approach.
Predicting Surgical Intervention for Airway Obstruction in Micrognathic Infants

Objective To determine which factors present in the neonatal period may predict subsequent need for surgical intervention in infants with micrognathia. Study Design Case series with chart review. Setting Two, urban, tertiary pediatric hospitals. Subjects and Methods The otolaryngology databases from 2 institutions were queried for the diagnosis of micrognathia over a 10-year period, and 123 infants were identified (101 with Pierre Robin sequence and 21 with micrognathia without cleft palate). The presence or absence of surgical airway intervention during the first year of life was noted, as were associated diagnoses. Univariate and multivariate analyses were performed to identify risk factors for requiring a definitive airway intervention. Results Forty-eight (39%) micrognathic children required definitive airway intervention during infancy in this series. These interventions came in the form of either tracheostomy (12 patients), mandibular distraction osteogenesis (MDO; 33 patients) or prolonged intubation prior to death (3 patients). Factors associated with a need for intervention included a history of intubation or tracheotomy in the first 24 hours of life (odds ratio [OR], 8.22; confidence interval [CI], 3.14-21.53), a history of intrauterine growth restriction (OR, 4.10; CI, 1.00-16.70), prematurity (<37 weeks of gestational age; OR, 2.38; CI, 1.02-5.56), and neurologic impairment (OR, 3.83; CI, 1.33-11.07). Those with isolated micrognathia without cleft palate were less likely to require intervention (OR, 0.20; CI, 0.05-0.71). Conclusions While it is understood that the need for MDO or tracheostomy should be determined on a case-by-case basis, this study identifies a number of factors that may predict which neonates with micrognathia are at increased risk for meriting early surgical intervention for respiratory and feeding problems.
The Political Origins of Coordinated Capitalism : Business Organizations , Party Systems , and State Structure in the Age of Innocence

This paper investigates the political determinants of corporatist and pluralist employers’ associations and reflects on the origins of the varieties of capitalism in the early decades of the 20th century. We hypothesize that proportional, multiparty systems tend to enable employers’ associations to develop into social corporatist organizations, whereas nonproportional, two-party systems are conducive to the formation of pluralist associations. Moreover, we suggest that federalism tends to reinforce incentives for pluralist organization. We assess our hypotheses through quantitative analysis of data from 1900 to the 1930s from 16 nations and case studies of the origins of peak employers’ associations in Denmark and the United States. Our statistical analysis suggests that proportional, multiparty systems foster, and federalism works against, social corporatist business organization; employers’ organization is also greater where the mobilization of labor, traditions of coordination, and economic development are higher. These factors also largely explain pre-World War II patterns of national coordination of capitalism. Case histories of the origins of employers’ associations in Denmark and the United States further confirm the causal importance of political factors. Although Danish and American employers had similar interests in creating cooperative national industrial policies, trajectories of associational development were constrained by the structure of party competition, as well as by preindustrial traditions for coordination.
Variance Swap for Local Lévy Based Stochastic Volatility with Delay

The valuation of the variance swaps for local Levy based stochastic volatility with delay (LLBSVD) is discussed in this paper. We provide some analytical closed forms for the expectation of the realized variance for the LLBSVD. As applications of our analytical solutions, we fit our model to 10 years of S&P 500 data (2000/01/01-2009/12/31) with variance gamma model and apply the obtained analytical solutions to price the variance swap.
The Effect of Effective Tax Rate Differentials and Clustering on Investment in Belgium

This paper looks at the effect of agglomeration economies on the tax sensitivity of investments in Belgian firms using detailed firm-level data. We find a negative effect of taxation on investment. However, this is dampened by the presence of agglomeration externalities. Our results hint to the importance of local labor market and supplying industries for firm investment decisions and follow the more nuanced view on tax competition of the New Economic Geography models.
Endogenous Ligand for GPR120, Docosahexaenoic Acid, Exerts Benign Metabolic Effects on the Skeletal Muscles via AMP-activated Protein Kinase Pathway*

Background: DHA is known as an endogenous ligand for GPR120. Results: DHA increased the phosphorylation of AMPK and induced glucose uptake in skeletal muscle cells. GPR120 is involved in DHA-mediated glucose uptake. Conclusion: DHA exerts a benign metabolic role through the AMPK pathway. Significance: DHA, a ligand for GPR120, is potential drug candidate for diabetes. Docosahexaenoic acid (DHA) is an endogenous ligand of G protein-coupled receptor 120 (GPR120). However, the mechanisms underlying DHA action are poorly understood. In this study, DHA stimulated glucose uptake in the skeletal muscles in an AMP-activated protein kinase (AMPK)-dependent manner. GPR120-mediated increase in intracellular Ca2+ was critical for DHA-mediated AMPK phosphorylation and glucose uptake. In addition, DHA stimulated GLUT4 translocation AMPK-dependently. Inhibition of AMPK and Ca2+/calmodulin-dependent protein kinase kinase blocked DHA-induced glucose uptake. DHA and GW9508, a GPR120 agonist, increased GPR120 expression. DHA-mediated glucose uptake was not observed in GPR120 knockdown conditions. DHA increased AMPK phosphorylation, glucose uptake, and intracellular Ca2+ concentration in primary cultured myoblasts. Taken together, these results indicated that the beneficial metabolic role of DHA was attributed to its ability to regulate glucose via the GPR120-mediated AMPK pathway in the skeletal muscles.
Collaborative glaucoma care

1. Rao SK, Parikh S, Padhmanabhan P. Isolated posterior capsule rupture in blunt trauma: pathogenesis and management. Ophthalmic Surg Lasers 1998; 29: 338– 42. 2. Vajpayee RB, Angra SK, Honavar SG, Titiyal JS, Sharma YR, Sakhuja N. Pre-existing posterior capsule breaks from perforating ocular injuries. J Cataract Refract Surg 1994; 20: 291–4. 3. Vajpayee RB, Sinha R, Singhvi A, Sharma N, Titiyal JS, Tandon R. ‘Layer by layer’ phacoemulsification in posterior polar cataract with pre-existing posterior capsular rent. Eye 2008; 22: 1008–10. 4. Grewal DS, Basti S, Grewal SPS. Femtosecond laser assisted cataract surgery in a subluxated traumatic cataract. J Cataract Refract Surg 2014; 40: 1239–40. 5. Nagy ZZ, Kranitz K, Takacs A, Filkorn T, Gergely R, Knorz MC. Intraocular femtosecond laser use in traumatic cataracts following penetrating and blunt trauma. J Refract Surg 2012; 28: 151–3. SUPPORTING INFORMATION
A Randomized Control Trial of a High Intensity Interval Training Program on Psychological Outcomes

by Richard Lewis Young, Ph.D. Washington State University July 2017 Chair: Janet Beary The aim of this study was to determine if contrasting forms of exercise intensities promote differing psychological outcomes that bolster tolerance and recovery from acute distressing events through cross-stressor adaptation. Repeated successions of physiologic stress that accompanies exercise may result in neurobiological adaptations that lead to a reduction in sensitivity to subsequent similar stimuli. These adaptations may also lead to the reduction in differing stimuli, such as a distressful event. Therefore, the intent of the study was to determine if high intensity interval training compared to moderate intensity steady-state training lead to contrasting psychological and physiological outcomes when exposed to acute distress. Twenty five participants between 18-55 years of age were randomized into high intensity interval training or moderate intensity continuous training for 6 weeks with 3 exercise sessions per week. Before exercise intervention, participants were subjected to the Trier Social Stress Test (TSST) while Blood Pressure (BP) and Heart Rate (HR) were monitored and salivary cortisol (SA) samples taken before and after the TSST. Additionally, Perceived Stress Scale -10 (PSS-10), and Strait Trait Anxiety Inventory (STAI) were completed by each participant. The same
Surface EMG signal decomposition using empirically sustainable biosignal separation principles

We introduce the concept of empirically sustainable principles for biosignal separation as a means of addressing the complexities that are practically encountered in the decomposition of surface electromyographic (sEMG) signals. Recently, we have identified two new principles of this type. The first principle places upper bounds on the inter-firing intervals and residual signal energies of the separated components. The second principle seeks a local minimum in the coefficient of variation of inter-firing intervals of each separated component. Upon incorporation of these principles into our latest Precision Decomposition system for sEMG signals, 20 to 30 motor unit action potential trains (MUAPTs) were decomposed per experimental sEMG signal from isometric contractions with trapezoidal force profiles. Our new system performs well even as the force generated by a muscle approaches maximum voluntary levels.
Dectin-1-mediated Signaling Leads to Characteristic Gene Expressions and Cytokine Secretion via Spleen Tyrosine Kinase (Syk) in Rat Mast Cells*

Background: β-Glucan receptor Dectin-1 in dendritic cells and macrophages plays important roles in antifungal immunity. Results: Dectin-1 is expressed in rat mast cells, and its tyrosine phosphorylation induces characteristic gene expression of transcription factors and cytokines through protein-tyrosine kinase Syk. Conclusion: Dectin-1 functions in rat mast cells. Significance: Dectin-1-mediated signaling in mast cells may contribute to antifungal immunity. Dectin-1 recognizes β-glucan and plays important roles for the antifungal immunity through the activation of spleen tyrosine kinase (Syk) in dendritic cells or macrophages. Recently, expression of Dectin-1 was also identified in human and mouse mast cells, although its physiological roles were largely unknown. In this report, rat mast cell line RBL-2H3 was analyzed to investigate the molecular mechanism of Dectin-1-mediated activation and responses of mast cells. Treatment of cells with Dectin-1-specific agonist curdlan induced tyrosine phosphorylation of cellular proteins and the interaction of Dectin-1 with the Src homology 2 domain of Syk. These responses depended on tyrosine phosphorylation of the hemi-immunoreceptor tyrosine-based activation motif in the cytoplasmic tail of Dectin-1, whereas they were independent of the γ-subunit of high-affinity IgE receptor. DNA microarray and real-time PCR analyses showed that Dectin-1-mediated signaling stimulated gene expression of transcription factor Nfkbiz and inflammatory cytokines, such as monocyte chemoattractant protein-1, IL-3, IL-4, IL-13, and tumor necrosis factor (TNF)-α. The response was abrogated by pretreatment with Syk inhibitor R406. These results suggest that Syk is critical for Dectin-1-mediated activation of mast cells, although the signaling differs from that triggered by FcϵRI activation. In addition, these gene expressions induced by curdlan stimulation were specifically observed in mast cells, suggesting that Dectin-1-mediated signaling of mast cells offers new insight into the antifungal immunity.
Impact of sunlight on the age of onset of bipolar disorder

Bauer M, Glenn T, Alda M, Andreassen OA, Ardau R, Bellivier F, Berk M, Bjella TD, Bossini L, Del Zompo M, Dodd S, Fagiolini A, Frye MA, Gonzalez‐Pinto A, Henry C, Kapczinski F, Kliwicki S, König B, Kunz M, Lafer B, Lopez‐Jaramillo C, Manchia M, Marsh W, Martinez‐Cengotitabengoa M, Melle I, Morken G, Munoz R, Nery FG, O’Donovan C, Pfennig A, Quiroz D, Rasgon N, Reif A, Rybakowski J, Sagduyu K, Simhandl C, Torrent C, Vieta E, Zetin M, Whybrow PC. Impact of sunlight on the age of onset of bipolar disorder. Bipolar Disord 2012: 14: 654–663. © 2012 The Authors. Journal compilation © 2012 John Wiley & Sons A/S.
Molecular cloning, expression, and DNA sequence analysis of the gene that encodes the 16-kilodalton outer membrane lipoprotein of Serpulina hyodysenteriae

The gene (smpA) that encodes the 16-kDa outer membrane lipoprotein of Serpulina hyodysenteriae was cloned in Escherichia coli, and its primary structure was determined by nucleotide sequencing. The putative open reading frame encodes a prolipoprotein of 16.8 kDa which in its fully acylated and cleaved form is 15.1 kDa. Analysis of the N-terminal amino acid sequence derived from the DNA sequence revealed the presence of a signal sequence and a putative acylation and signal peptidase II cleavage site (Phe-Ala-Val-Ser-Cys). In E. coli, processing of the prolipoprotein was less efficient than that observed in S. hyodysenteriae, and globomycin, an inhibitor of signal peptidase II, inhibited cleavage of the lipoprotein expressed in E. coli but did not inhibit cleavage in S. hyodysenteriae.
Feature-Based Mapping in Real, Large Scale Environments Using an Ultrasonic Array

This paper presents a strategy for achieving practical mapping navigation using a wheeled mobile robot equipped with an advanced sonar sensor The original mapping navigation experiment, carried out with the same robot configuration, built a feature map consisting of common-place indoor landmarks crucial for localization; namely, planes, corners, and edges. The map exhaustively maintained covariance matrices among all features, and thus presented a time and memory impediment to practical navigation in large environments. The new local mapping strategy proposed here breaks down a large environment into a topology of local regions, only maintaining the covariance among features in the same local region, and the covariance among local maps. This notion of two-hierarchy representation drastically improves the memory and processing-time requirements of the original global approach, while preserving the statistical details, in the authors' opinions, necessary for an accurate map and prolonged navigation. The new local mapping scheme also extends the endeavor toward reducing error accumulation made in the global mapping strategy by eliminating errors accumulated between visits to the same part of the environment. This is achieved with a map-matching strategy developed exclusively for the advanced sonar sensor that is employed. The local mapping strategy has been tested in two large, real-life indoor environments, and successful results are reported here.
Do Rewards Reinforce the Growth Mindset?: Joint Effects of the Growth Mindset and Incentive Schemes in a Field Intervention

The current study draws on the motivational model of achievement which has been guiding research on the growth mindset intervention (Dweck & Leggett, 1988) and examines how this intervention interacts with incentive systems to differentially influence performance for high- and low-achieving students in Indian schools that serve low-SES communities. Although, as expected, the growth mindset intervention did interact with incentive systems and prior achievement to influence subsequent academic performance, the existing growth mindset framework cannot fully account for the observed effects. Specifically, we found that the growth mindset intervention did facilitate performance through persistence, but only when the incentive system imparted individuals with a sense of autonomy. Such a facilitation effect was only found among those students who had high prior achievement, but not among those who had underperformed. When the incentive did not impart a sense of autonomy, the growth mindset intervention undermined the performance of those who had high initial achievement. To reconcile these discrepancies and to advance understanding of the impacts of psychological interventions on achievement outcomes, we discuss how the existing theory can be extended and integrated with an identity-based motivation framework (Oyserman & Destin, 2010). We also discuss the implications of our work for future research and practice.
Smad3 deficiency attenuates renal fibrosis, inflammation,and apoptosis after unilateral ureteral obstruction.

BACKGROUND Transforming growth factor-beta (TGF-beta) has been implicated in the development of renal fibrosis induced by unilateral ureteral obstruction (UUO). However, there is little information on signaling pathways mediating TGF-beta activity involved in molecular and cellular events leading to renal fibrosis induced by UUO. In this study, we sought to determine whether Smad3, a major signaling component of TGF-beta, mediated renal fibrosis induced by UUO. METHODS Renal fibrosis, inflammation, and apoptosis induced by UUO were macroscopically and histologically compared between wild-type mice and Smad3 null mice. RESULTS Gross appearance of the kidney after UUO showed relatively intact kidney in Smad3 null mice [Smad3(-/-) mice] when compared with that of wild-type mice [Smad3(+/+) mice]. Renal interstitial fibrosis based on the interstitial area stained with Aniline-blue or Sirius red solution was significantly attenuated in the obstructed kidney of Smad3(-/-) mice when compared with that of Smad3(+/+) mice. Deposition of type I and type III collagens were also significantly reduced in the obstructed kidney of Smad3(-/-) mice. In addition, the numbers of myofibroblasts, macrophages, and CD4/CD8 T cells infiltrated into the kidney after UUO were significantly attenuated in the obstructed kidney of Smad3(-/-) mice when compared with that of Smad3(+/+) mice. Furthermore, terminal deoxynucleotidyltransferase-mediated deoxyuridine triphosphate (dUTP) nick-end labeling (TUNEL) staining after UUO showed significantly reduced number of tubular apoptotic cells in the obstructed kidney of Smad3(-/-) mice when compared with that of Smad3(+/+) mice. Endogenous Smad pathway was activated in the obstructed kidney after UUO in wild-type mice as judged by the increase of phosphorylated Smad2 or phosphorylated Smad2/3-positive cells in renal interstitial area. CONCLUSION Smad3 deficiency attenuated renal fibrosis, inflammation, and apoptosis after UUO, suggesting that Smad3 was a key molecule mediating TGF-beta activity leading to real fibrosis after UUO.
The activation logic in national sickness absence policies: Comparing the Netherlands, Denmark and Ireland

We compare sickness absence policies in the Netherlands, Denmark and Ireland, examining whether and how the institutional logic of ‘activation’ that is paramount in Europe is understood and given shape in each country. They differ in their support for the underlying ideas of ‘activation’, and especially vary in the design of their governance systems, as can be seen in the allocation of responsibilities, the description of return-to-work routines and the use of regulative instruments. We contribute to institutional theory by demonstrating the important but often neglected role of national governance systems in the macro–micro linkage between institutional logics and organizational and individual behaviour. Since sickness absence is a major cause of workforce inactivity, the practical relevance of this study is the comparative reflection on recent policy developments to improve sickness absence management.
Mathematical modeling improves EC50 estimations from classical dose–response curves

The β‐adrenergic response is impaired in failing hearts. When studying β‐adrenergic function in vitro, the half‐maximal effective concentration (EC50) is an important measure of ligand response. We previously measured the in vitro contraction force response of chicken heart tissue to increasing concentrations of adrenaline, and observed a decreasing response at high concentrations. The classical interpretation of such data is to assume a maximal response before the decrease, and to fit a sigmoid curve to the remaining data to determine EC50. Instead, we have applied a mathematical modeling approach to interpret the full dose–response curve in a new way. The developed model predicts a non‐steady‐state caused by a short resting time between increased concentrations of agonist, which affect the dose–response characterization. Therefore, an improved estimate of EC50 may be calculated using steady‐state simulations of the model. The model‐based estimation of EC50 is further refined using additional time‐resolved data to decrease the uncertainty of the prediction. The resulting model‐based EC50 (180–525 nm) is higher than the classically interpreted EC50 (46–191 nm). Mathematical modeling thus makes it possible to re‐interpret previously obtained datasets, and to make accurate estimates of EC50 even when steady‐state measurements are not experimentally feasible.