Miracle-dz/UniFAR-FTUs huggingface dataset:
University of Dundee Peripheral Vascular Responses to Acetylcholine as a Predictive Tool for Response to Cholinesterase Inhibitors in Alzheimer ' s Disease

Background: Cholinesterase inhibitors remain the first line therapy for people with mild to moderate Alzheimer’s disease (AD). Response is modest and difficult to predict from pre-treatment characteristics. We hypothesise that skin vascular response to iontophoresis of acetylcholine, which is partly determined by the level of cholinesterase activity, may be a pre-treatment measure that could predict response to therapy. Methods: Twenty-four people with probable AD underwent iontophoresis of acetylcholine to the volar surface of the forearm skin prior to treatment with a cholinesterase inhibitor. The peak skin vascular response and the resolution to baseline levels were measured using laser Doppler perfusion imaging. Response to treatment was assessed after 6 months using criteria from the National Institute for Health and Care Excellence (NICE) and iontophoresis with acetylcholine was repeated. Blindness between clinical and laboratory assessments was maintained. Results: Fourteen out of twenty-four people responded to treatment using NICE criteria. By comparison to nonresponders, responders to treatment had a faster resolution to baseline from acetylcholine-induced vasodilation prior to treatment, which slowed with treatment. In this pilot study there was a high level of accuracy in the classification of response using this variable. No baseline cognitive or functional measures discriminated end-point responders from non-responders. Conclusion: Cholinesterase inhibitors are well tolerated but the number of people with adverse effects would be reduced if it was possible to predict response. The role of vasodilator response to acetylcholine and recovery as a potential biomarker for efficacy of treatment should now be evaluated and may possibly be of relevance in stratifying samples for interventional studies in AD and other forms of dementia. We feel that a more definitive study is now justified.
Genetic Analysis of the Role of GRP 170 B ( T 14 G 8 . 3 ) During Toxin Induced Protein Folding Stress in Caenorhabditis elegans

of a Thesis Genetic Analysis of the Role of the Chaperone GRP170B (T14G8.3) During Toxin Induced Protein Folding Stress in Caenorhabditis elegans Chaperones maintain cellular homeostasis by facilitating protein folding. However, under standard cultured conditions, Caenorhabditis elegans strains genetically deficient for the ER chaperone GRP170B (encoded by the T14G8.3 locus) seems unaffected by the loss of this large chaperone. For most ER chaperones, the loss of GRP170B chaperone increases sensitivity to toxins that disrupt protein folding in the ER. I hypothesized that GRP170B’s role may involve mediating the nematodes response to ER protein folding stress. To investigate a stress role for GRP170B chaperone, I analyzed the effect of toxins that are known to effect ER protein folding on nematodes deficient for the chaperone. The three toxins tested I tested were: 1. tunicamycin (TM), an ER glycosylation inhibitor, 2. dithiothreitol (DTT), a disrupter of disulfide bond formation and 3. thapsigargin (TG) an inhibitor of an ER calcium pump which disrupts protein folding by interfering with the activity of calcium dependent ER chaperones. Eggs of nematodes deficient for GRP170B (strain BSC06) and the control strain (N2) were cultured at varying doses of each toxin, and the development of the nematodes was monitored. At 80-320 g/μl of TM, the GRP170B deficient worms were less sensitive to the toxin than the control strain. This was similar to a previous study which found that nematodes deficient for GRP170B were less sensitive to 3 μg/ml TM. At the highest dose of TM tested (640 μg/μl), development was similar in nematodes with and without GRP170B. Results showed that at low doses of the second toxin DTT (80-320 g/μl), development was similar in nematodes with and without GRP170B. However, at highest dose (640 g/μl) GRP170B deficient worms were more sensitive to the toxin and none of them developed to L4/adult stages. For the third toxin tested, TG there was a notable experimental variation across all treatments from 0.5 M to 1.25 M. The effect of TG on development of nematodes deficient for GRP170B was also tested. Thapsigargin doses (0.5 nM to 5 nM) did not affect the development of either strain. These data demonstrate that GRP170B deficient worms are not being affected specifically with one toxin versus the other. These data revealed that GRP170B has a critical role during normal C. elegans physiology role and during stress physiology with the use TM. However, the role of GRP170B could not be determined using DTT and TG at the tested doses. State University of New York College at Buffalo Department of Biology Genetic Analysis of the Role of GRP170B (T14G8.3) During Toxin Induced Protein Folding Stress in Caenorhabditis elegans. A Thesis in Biology By Nancy Tito Nsengiyumva Submitted in Partial Fulfillment Of the Requirements For the Degree of Master of Arts December 2018
PROFILE OF SEVERE FALCIPARUM MALARIA IN DIABETICS

Clinical profile of severe falciparum malaria in diabetics was compared with non-diabeties. 76 patients of severe falciparum malaria with diabeties and 72 non diabetics were enrolled in this study. The diagnosis of severe falciparum malaria and diabetes mellitus was made in accordance with WHO guidelines. The detailed clinical work up was done in all cases. Blood was collected for hematological and biochemical investigations. The results showed that 17.4% patients of malaria had diabetes mellitus. Absence of fever at the time of admission was found in 21% diabetic patients with malaria. Multi-organ involvement was more common (15.1%) in diabetics. Relative bradycardia, hypoglycemia at the time of admission and diabetic ketoacidosis was present in 26.3%, 8.3% and 2.6% cases respectively. The coma-onset time was shorter and duration of coma was longer in diabetics. The mortality was higher (34.2%) in diabetics. After administration of quinine, side effects like hypoglycemia and cardiac arrhythmia were present in 7.8% and 5.2% cases respectively. This study showed that multi organ dysfunction was present in 15.4% cases. It also showed that atypical presentations like absence of fever, presence of hypoglycemia and keto acidosis could delay the diagnosis and treatment, which may cause higher mortality. In view of the quinine-induced toxicity, its should be used with caution in diabetics. The dose of insulin should be reduced while treating such patients with quinine.
Haptic interfaces for virtual environment and teleoperator systems

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Deposited in DRO : 13 May 2019 Version of attached le : Published Version Peer-review status of attached

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Dynamic service orchestration in the IP multimedia subsystem

Telecommunication operators have begun moving to an all IP-based Next Generation Network (NGN) to save costs as well as enabling the rapid development of new services. A NGN is defined as a packet-based network where the service functionality is independent of the underlying transport technologies. The IP Multimedia Subsystem (IMS) is considered to be an intrinsic part of a NGN, and it provides mechanisms such as user authentication, Quality of Service (QoS) and charging. Traditionally, these mechanisms had to be created for each new service that the network operator wished to offer. The ability to reuse these features greatly speeds up the development of new services. This, together with the open protocols being used for the control signalling, is predicted to create a vast increase in the number of services being offered by the network operator as specialised telephony knowledge is no longer needed to develop new services. This increase in the number of potential services on offer has exacerbated the traditional problem of service conflict detection and resolution. This paper describes the current state of research in this area, discussing the advantages and disadvantages of current systems, as well as proposing a novel design that aims to address this issue.
Syddansk Universitet Genetically determined high activities of the TNF-alpha , IL 23 / IL 17 , and NFkB pathways were associated with increased risk of ankylosing spondylitis

Background: Ankylosing spondylitis (AS) results from the combined effects of susceptibility genes and environmental factors. Polymorphisms in genes regulating inflammation may explain part of the heritability of AS. Methods: Using a candidate gene approach in this case-control study, 51 mainly functional single nucleotide polymorphisms (SNPs) in genes regulating inflammation were assessed in 709 patients with AS and 795 controls. Data on the patients with AS were obtained from the DANBIO registry where patients from all of Denmark are monitored in routine care during treatment with conventional and biologic disease modifying anti-rheumatic drugs (bDMARDs). The results were analyzed using logistic regression (adjusted for age and sex). Results: Nine polymorphisms were associated with risk of AS (p < 0.05). The polymorphisms were in genes regulating a: the TNF-α pathway (TNF -308 G > A (rs1800629), and − 238 G > A (rs361525); TNFRSF1A -609 G > T (rs4149570), and PTPN22 1858 G > A (rs2476601)), b: the IL23/IL17 pathway (IL23R G > A (rs11209026), and IL18–137 G > C (rs187238)), or c: the NFkB pathway (TLR1 743 T > C (rs4833095), TLR4 T > C (rs1554973), and LY96–1625 C >G (rs11465996)). After Bonferroni correction the homozygous variant genotype of TLR1 743 T > C (rs4833095) (odds ratios (OR): 2.59, 95% confidence interval (CI): 1.48–4.51, p= 0.04), and TNFRSF1A -609 G > T (rs4149570) (OR: 1.79, 95% CI: 1.31–2.41, p= 0.01) were associated with increased risk of AS and the combined homozygous and heterozygous variant genotypes of TNF -308 G > A (rs1800629) (OR: 0.56, 95% CI: 0.44–0.72, p = 0.0002) were associated with reduced risk of AS. Conclusion: We replicated associations between AS and the polymorphisms in TNF (rs1800629), TNFRSF1A (rs4149570), and IL23R (rs11209026). Furthermore, we identified novel risk loci in TNF (rs361525), IL18 (rs187238), TLR1 (rs4833095), TLR4 (rs1554973), and LY96 (rs11465996) that need validation in independent cohorts. The results suggest that genetically determined high activity of the TNF-α, IL23/IL17, and NFkB pathways increase risk of AS.
RISK FACTORS AND LABOR OUTCOME

This is a case-control comparative study carried out in Al-Basrah maternity & child hospital to estimate the frequency of macrosomic newborns among all deliveries conducted in the study period (November 2008-September 2009) to identify demographic, medical and obstetrical risk factors that carry risk of macrosomia as well as to assess labor and neonatal outcome. All gravid women who delivered macrosomic newborns during the study period were included who constitute 208 cases. This case group was compared to 250 gravid women who were selected among those who delivered newborns with birth weight of 3.000gms and more and less than 4.000 gms as control group. Macrosomic newborns constitute 1.4% of all deliveries. Advanced maternal age, high parity and obesity were the main demographic risk factors. Other factors which carry risk for macrosomia include previous macrosomic infant, prolonged gestation, maternal D.M and hypertension and male sex of newborn. Macrosomic newborns were delivered more likely by cesarean section which was indicated commonly for cephalo-pelvic disproportion. Those who delivered macrosomic newborns had significantly higher obstetrical complications in term of meconium stained liquor, prolonged labor, postpartum hemorrhage and genital tract injury. Adverse neonatal outcome was reported among macrosomic newborns with significantly higher rate of stillbirth, shoulder dystocia and low apgar score. In conclusion; macrosomia still represent a significant problem with increased maternal morbidity, neonatal morbidity and mortality.
TOPOLOGICAL TRIVIALITY OF FAMILIES OF MAP GERMS FROM R TO R

We show that a 1-parameter unfolding F : (R2 ×R, 0)→ (R2 ×R, 0) of a finitely determined map germ f is topologically trivial if it is excellent in the sense of Gaffney and the family of the discriminant curves ∆(ft) is topologically trivial. We also give a formula to compute the number of cusps of 1-parameter unfoldings.
Submission and Information for Authors

Classical virtue theory provides a fruitful framework for understanding charismatic leadership. The article outlines the theory of virtues and demonstrates the contribution of virtues to the personality traits and behaviors that are associated with charisma. The virtue of magnanimity or high-mindedness is shown to play a special role. The virtue-based perspective to charismatic leadership clarifies disagreements concerning the definition and delineation of the concept of charisma. It also provides a novel framework for analyzing and criticizing charismatic leadership training programs. Finally, the article demonstrates that the dark side of charisma is a deformation caused by the absence of specific virtues such as prudence, justice or
Influence of infective stage (L3) dose on the outcome of microfilaremia, peripheral white blood cells and humoral immune response in Loa loa experimentally infected Mandrillus sphinx

Analyses were performed to assess how the dose and frequency of administration of the natural infective stage (L3) affects events in the peripheral blood of an infected host. A blood sample was collected from different mandrills (Mandrillus sphinx) infected once with 1000 L3 Loa loa, 250 L3 four times, 100 L3 once and 25 L3 four times. Enzyme-linked immunosorbent assay (ELISA) was used to measure levels of microfilaria-specific IgG and Western blotting to identify antigens. Fluctuation in the number of neutrophils, eosinophils and monocytes was seen during prepatency and patency in relation with some L3 doses. The density of microfilaria in the peripheral blood showed that animals that received 1000 L3 had the highest density of microfilaria as compared to those that received 250L3 ×4, 100L3 ×1 or 25L3 ×4. In contrast, the microfilaria-specific IgG level was higher in animals that received doses of 25 L3 ×4 as compared to those that received 1000 L3 ×1 (p 0.05). Identification of microfilaria antigens recognized by this specific IgG on Western blotting revealed the presence of 23-, 20- and 14-kDa antigens specifically in animals that developed patent infection. These results suggest that the regimen of L3 administration may have an effect on the level of humoral immune response and to some extent on the density of microfilaria. Key words: Loa loa, Helminths, larvae, immunology, primate.
COMPARATIVE STUDY OF THE EFFECT OF SOME DISINFECTANTS ON EMBRYONIC MORTALITY , HATCHABILITY , AND SOME BLOOD COMPONENTS

The present study was carried out to investigate the effect of some different chemical egg disinfectants against bacteria and to study its effect on embryonic mortality, hatchability and some blood biochemicals parameters. A total of 525 hatching eggs (38-wk-old Golden Montazah) were randomly distributed to seven equal groups. The first group was disinfected by formaldehyde. The second, third and fourth groups were sprayed by 3, 5 and 7% Hydrogen peroxide. While, the fifth, sixth and seventh groups were sprayed by 0.1, 0.5 and 0.7% TH4 (DDAG). Total bacterial counts on hatching eggshell surface and chicks’ caeca salmonella counts, embryonic mortality, hatching percentage, hatched chicks’ weight, and relative weights of liver and spleen were measured. Serum total protein, albumin, globulin, glucose, uric acid, creatinine, alanine transaminase, aspartate transaminase, and triiodothyronine concentrations were determined. Results indicated that the total number of bacterial counts were significantly higher at pre-disinfection than post-disinfection. The lowest number of bacteria detected was that of the 7% of Hydrogen peroxide and 0.7% TH4 groups. Total embryonic mortality was significantly lower, while, hatchability percentage was higher in the formaldehyde group than the other disinfectants groups. Also, hatchability traits were significantly better while, embryonic mortality were significantly lower in the 5% Hydrogen peroxide group. In addition, protein profiles, glucose, and triiodothyronine concentrations were significantly lowered, while, kidney and liver functions were significantly higher in the formaldehyde group. While, its values improved in the 5% Hydrogen peroxide group. In conclusion, our results recommended using 5% Hydrogen peroxide as egg disinfectants against bacteria due to its effectiveness and ease of application
Moodle Implementation for L 2 Vocabulary Development and Retention : The Effects on Extroverted vs . Introverted Iranian Intermediate EFL Learners

Despite all the studies conducted on second/foreign language (L2) vocabulary, most L2 learners suffer from deficiency in their vocabulary development and retention. One of the probable reasons behind this specifically in Iranian EFL context is that less implementation of new technologies such as CALL and Virtual Learning Environments (VLEs). Because the use of new language learning technologies is likely related to learner variables and personality differences, the present study attempted to examine the use of Moodle as an effective type of VLE on 90 introverted vs. extroverted EFL learners' vocabulary development and retention. Myers Briggs Type Indicator (MBTI), researcher-made and validated vocabulary tests used as pretest, posttest, and delayed posttest were employed for data collection. The application of two-way ANOVA indicated that Moodle had a significant positive effect on L2 vocabulary development and retention. However, introversion/extroversion personality factor could not moderate the effect of Moodle on vocabulary learning and retention. The interaction effect of the two independent variables on vocabulary development and retention was not significant as well. Study findings suggest that EFL practitioners and learners can employ Moodle as an effective VLE for L2 vocabulary achievement and retention.
Modeling Forest Type Transitions in the Southcentral Region: Results from Three Methods

In recent years much interest has developed about the dynamics of forest type transitions, especially the transitions of land to and from southern pine plantations. This article presents 50-yr-forest type projections developed from two approaches to specifying the type transition matrices. One approach used transition matrices derived with remeasured plot data for six forest types using USDA Forest Service Forest Inventory and Analysis data. These data tracked transitions that occurred either naturally or artificially on inventory plots during one remeasurement cycle. The second approach relied on expert opinion surveys that predicted trends in the future of forest management. The transition matrices were developed from the responses regarding managers’ intentions to regenerate stands following harvest. The survey was developed for the 2000 Forest and Rangeland Renewable Resources Planning Act Timber Assessment (2000 RPA). The timber inventories in eight states in the southcentral United States are projected with these methods of handling type transitions, and the results are compared to the 2000 RPA, which used a combination or hybrid approach to type transitioning. All three techniques conclude the area of planted pine is expected to increase well into the future. They are contradictory, however, in predicting the area other forest types will occupy, especially natural pine and upland hardwoods. Projections based on recent history give us one result; projections based on managers’ intentions show another. South. J. Appl. For. 27(3):190–197.
Comparative Advantage of Siamese Orange ( Citrus Nobilis ) Farming in District of 50 City , West

Citrus Nobilis, known as Siamese Orange, is one of the strategic fruits commodities for West Sumatera because of its high productivity, approximately 6 9 tons per hectare. However, this commodity faces a fluctuated demand both in domestic and international markets. This is a serious problem due to its impact on farm income as well as in its comparative advantage. The aim of this study was to analyze the comparative advantage level of siamese orange farming. Eighty four Siamese Orange farmers are selected using simple random sampling to get orange farming data. The comparative advantage level is measured with Policy Analysis Matrix (PAM) approach. The results show that siamaese orange farming has a high comparative advantage, indicating by more than zero value of social profitability and less than one domestic resource cost ratio. This comparative advantage could be sustained if domestic resources are efficiently utilized through the improvement of labor skills and the use of Siamaese Orange farming modern technology.
IMPACT OF GENDER DETERMINATION THROUGH VENT SEXING ON COBB-500 BROILER PERFORMANCE AND CARCASS YIELD

The study was conducted in order to explore the effect of separated sex rearing of broiler production performance. Total no of (n=24,000) Cobb-500 birds were reared for 42 days and divided in two group’s A =12000 male and B= 12,000 females, according to their sex with 4 replication in each treatment where each replication had 3000 birds. They were provided the same feed and water ad libitum for the whole study. Initial body weight, temperature, humidity, feed intake, weekly body weight, mortality and final live weight of broiler were recorded. The study clearly shows significant differences (P<0.05) in term of body weight gain and FCR for males chicks compare to females. Male birds also showed significantly (P<0.05) better dressing percentage than female group. Male chicks had significantly (P<0.05) larger chest circumference females birds. The cross with the fastest growth rate also had the highest mortality. Mortality percentage was high in male chicks 4% then female’s chicks 2%. The most profitable choice will be dependent on whether whole birds or parts are marketed and the relative values of the parts. All these findings together revealed that in separate sex growing male chicken showed better performance in terms of more production.