Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of sleep quality on amnestic mild cognitive impairment vulnerable brain regions in cognitively normal elderly individuals

STUDY OBJECTIVES This study aims to evaluate the extent to which sleep quality impacts amnestic mild cognitive impairment (aMCI)-related brain regions in a cognitively normal cohort of individuals. METHODS Seventy-four participants were rigorously evaluated using a battery of cognitive tests and a detailed clinical assessment to verify normal cognitive status. We then screened for sleep quality using the Pittsburgh Sleep Quality Index (PSQI) and depressive symptoms using the Geriatric Depression Scale (GDS). Five subjects were excluded due to mild depression. Overall 38 individuals with mean age 70.7 ± 7 were classified as poor sleepers and 31 with mean age of 69.6 ± 6 years as normal sleepers. Structural MRI and Freesurfer brain parcellation were used to measure aMCI-related brain regions. RESULTS Relative to normal sleepers, poor sleepers exhibited significant reductions in cortical and subcortical volumes bilaterally in the hippocampi, as well as in the superior parietal lobules and left amygdala. The effects were strongest in the left superior parietal lobule (p < .015), followed by the hippocampi. Diffuse patterns of cortical thinning were observed in the frontal lobes, but significant effects were concentrated in the right mesial frontal cortex. Lower sleep duration was most correlated with cortical volume and thickness reductions among all subjects. CONCLUSIONS Atrophy related to poor sleep quality impacted a number of regions implicated in aMCI and Alzheimer's disease (AD). As such, interventions targeted towards improving sleep quality amongst the elderly may prove an effective tool for modulating the course of aMCI and AD.
The Conjoined View of Online Communities: Coexistence of Community and Commodity

There is a continued interest amongst information system scholars on online communities (OCs). Current accounts, however, often neglect the complex relations and tensions that exist within and between community participants. This is in particular, where these online communities emerge from and around the adoption of large commercial systems, the tensions between these communities and the vendors of the technologies. This existing ‘community’ perspective envisions OCs as idealised microcosm of society. In this paper, we criticise this view by drawing attention to the co-existence of conflicts of interests and collaborations within communities. This brings into light the ‘commodity’ view
ICT as an Enabler: Understanding the Role of Online Communication in the Social Inclusion of Syrian Refugees in Germany

Following recent call for papers, our paper contributes to the agenda of inclusive development as it showcases how technology can be used to foster the integration of those in need. In particular, due to the distinct role of ICT in the current refugee situation in Europe where it contributes to the social inclusion of refugees. Based on a thorough literature review, we conducted a comprehensive research with qualitative and quantitative studies to investigate the role of online communication on the social inclusion of Syrian refugees in Germany. In particular, we investigate the relation between the intensity of Internet use and the sense of social connectedness of refugees, as well as the impact of social connectedness on refugee social inclusion. Analyzing ten interviews, we derive new insights about social inclusion of Syrian refugees in Germany. We use these insights to construct our hypotheses that are validated through 135 participations in our questionnaire. Our hypotheses capture the relation in Internet use and social connectedness, social connectedness with family and friends, and social connectedness with locals. We believe that our findings could contribute to a successful social inclusion process.
Right temporal alpha oscillations as a neural mechanism for inhibiting obvious associations

Significance “Taking a less-traveled path” is often considered an effective approach to creativity (i.e., creative thinking calls for a break from habitual thinking and associations), yet little is known about its underlying neural mechanism. In a series of four independent experiments involving electrophysiological and brain stimulation methods we provide evidence that this process is mediated by the right temporal alpha oscillations. Alpha oscillations are known to represent a process of active inhibition to suppress irrelevant information, such as inhibiting distractions during visual search. Through monitoring the brain’s electrical activity during different creativity tasks and by stimulating the right temporal brain region at the alpha frequency we show that a similar process of active inhibition is also key to creative thinking. Creative cognition requires mental exploration of remotely connected concepts while suppressing dominant ones. Across four experiments using different samples of participants, we provide evidence that right temporal alpha oscillations play a crucial role in inhibiting habitual thinking modes, thereby paving the way for accessing more remote ideas. In the first experiment, participants completed the compound remote associate task (RAT) in three separate sessions: during right temporal alpha (10 Hz) transcranial alternating current brain stimulation (tACS), left temporal alpha tACS, and sham tACS. Participants performed better under right tACS only on RAT items in which two of the three words shared misleading semantic associations. In the second experiment, we measured EEG while the participants solved RAT items with or without shared misleading associations. We observed an increase in right temporal alpha power when participants correctly solved RAT items with misleading semantic associations. The third experiment demonstrated that while solving divergent thinking tasks participants came up with more remote ideas when stimulated by right temporal alpha tACS. In the fourth experiment, we found that participants showed higher right temporal alpha power when generating more remote uses for common objects. These studies altogether indicate that right temporal alpha oscillations may support creativity by acting as a neural mechanism for an active inhibition of obvious semantic associations.
Detecting Herding Behavior using Topic Mining: the Case of Financial Analysts

The phenomenon of herding behavior can be observed throughout human societies and has been discussed from different perspectives in research areas such as information systems or finance. In this context, financial analysts have been found to exhibit a disposition towards herding behavior. We identify the topic selection within analyst reports as a potential source for the detection of herding behavior among financial analysts. In this paper, we utilize a qualitative dataset of about 140,000 analyst reports and 1,500 conference call transcripts. Building on the topic modeling technique latent Dirichlet allocation, we calculate similarity scores between the respective documents. Potential herding behavior is observable by revealing exceptional topic structures within groups of analyst reports. In this study, these are found especially during a phase of economic recession: the financial crisis spanning from 2008 to 2010. Viewing prospects, this approach might complement existing research in herding behavior by quantifying qualitative data not only within the financial domain but also in other research areas.
Three diagnostic psychiatric subgroups in comparison to self-stigma, quality of life, disorder severity and coping management cross-sectional outpatient study.

BACKGROUND Much attention has been paid to psychological factors influencing characteristics, severity, and course of mental disorders. The objective of our investigation was to examine the interrelations among quality of life (QoL), self-stigma, and coping strategies, demographics and severity of the disorder in neurotic spectrum disorders, schizophrenia, and depressive spectrum disorders. METHODS A total of 343 clinically stable Czech outpatients with different mental disorders (153 with neurotic spectrum disorders; 81 with depression, and 109 with schizophrenia spectrum disorders) were included. The patients were examined by their outpatient psychiatrists during regular psychiatric checkup and completed a sociodemographic questionnaire, the Quality of Life Satisfaction and the Enjoyment Questionnaire (Q-LES-Q), the Internalized Stigma of Mental Illness Scale (ISMI), the Stress Coping Style Questionnaire (SVF-78), and the Clinical Global Impression scale (CGI). RESULTS The study demonstrates that the self-stigma and coping strategies are significant factors linked to the QoL in all diagnostic groups of patients. Patients with schizophrenia spectrum disorders had lower scores in QoL compared to the other two groups. The patients with depression or neurotic spectrum disorders had a lesser degree of self-stigma than the patients with schizophrenia spectrum disorders. The severity of the illness significantly correlated with the QoL, self-stigma, and coping strategies. CONCLUSIONS The investigation confirmed the connection between the quality of life, self-stigma, coping strategies, and the severity of the illness, in outpatients with schizophrenia spectrum disorders, depressive, and neurotic spectrum disorders. A further longitudinal study would be useful to determine the causative relationships of these variables.
Toward an Operationalization of Effective Use

A major body of work in the IS discipline, studies of individuals’ technology acceptance and adoption are increasingly criticized for their shallow conceptualization of use behaviors, especially after adoption. To overcome such critique, Burton-Jones and Grange (2013) have recently proposed the construct of effective use (EU). While promising in its more refined perspective on what enables users to use an information system effectively (i.e., transparent interaction, representational fidelity, and informed action), much of this debate has been purely conceptual to date. We pick up EU’s extant conceptualization and propose a measurement model for it. Through engagement with field and panel data, we are able to validate our proposed measurements and, for the first time, are able to take a look at the exact empirical relationship between the sub-constructs that constitute EU. This helps to advance the extant EU conceptualization and enables future empirical work on its validation and extension.
Economic costs and health-related quality of life associated with individual specific reminiscence: Results from the InspireD Feasibility Study

Recent studies have focused on the use of technology to support reminiscence but there remains a dearth of research on the health costs and benefits associated with this intervention. The aim of this study was to estimate costs and quality of life associated with a home based, individual specific reminiscence intervention, facilitated by an iPad app for people living with dementia and their family carers, with a view to informing a future cost-effectiveness analysis. Use of community health and social care services, hospital services, prescribed medication and informal caregiving was assessed using an adapted version of the Client and Socio-Demographic Service Receipt Inventory (CSRI) at baseline and 3-month follow-up. Quality of life was assessed at baseline, 6-week and 3-month follow-up using the EQ5D, DEMQOL and DEMQOL proxy instruments. Results showed that average health and social care costs were £29,728 per person at baseline (T0) and £33,436 after 3 months (T2). Higher T2 costs were largely accounted for by higher informal caregiving costs. There was an overall increase in health-related quality of life over the duration of the intervention, although there were notable differences in index scores generated by the EQ5D (0.649, 0.652 and 0.719) and DEMQOL instruments (0.845, 0.968 and 0.901). The study concluded that a full cost-effectiveness analysis could incorporate a similar range of cost-categories with minor amendments to the CSRI to improve the accuracy of cost estimation. Furthermore, a larger sample size, randomisation and longer follow-up period are required to allow potential effects of the intervention to be realised and differences between intervention and control groups to be accurately detected.
Informing the Design of a Health Virtual Community of Practice: a Knowledge Translation Approach

Access to knowledge forms an integral part of the continuous learning processes of medical and other health professionals throughout their career. Modern technologies have become instrumental in ex-tending learning processes to the online realm, particularly through the use of social media technologies. Health Practitioners’ (HPs) exploitation of online social media technologies for online learning and knowledge sharing purposes has evolved into Virtual Communities of Practice (VCoP). However, there is limited research on the types of knowledge being shared to fulfil the notion of ‘knowledge-into-action’ in the healthcare domain. In addition, little is known of the use of online social media technologies as a catalyst to achieve ‘knowledge-into-action’. This research in progress paper extends the conceptual model from our previous work and draws on current literature that identifies the types of knowledge being shared in a Health VCoP. We discuss some of our data using our conceptual lens as a preliminary analysis of our work. Expected outcomes are a new extended conceptual model that fulfils the notion of ‘knowledge-into-action’ that informs the design of an IT artefact based on types of knowledge being shared in a Health VCoP.
Evaluation of Hybrid III and THOR-M neck kinetics and injury risk under various restraint conditions during full-scale frontal sled tests

Abstract Objective: The objective of this research was to compare the kinetics and predicted injury risks of the Hybrid III (HIII) and Test device for Human Occupant Restraint (THOR)-M necks during full-scale frontal sled tests under 3 safety restraint conditions: knee bolster (KB), knee bolster and steering wheel airbag (KB/SWAB), and knee bolster airbag and steering wheel airbag (KBAB/SWAB). Methods: Twelve sled tests were performed for the HIII and THOR-M, and 8 matched sled tests were performed using postmortem human surrogates (PMHSs). The tests were designed to match the 2012 Toyota Camry New Car Assessment Program (NCAP) full-scale crash test. Upper and lower neck forces and moments were collected from the HIII and THOR-M load cells. Inverse dynamics was used to calculate PMHS upper neck forces and moments from acceleration data until the time of head contact. The PMHSs experienced head contact with the SWAB before appreciable neck loading occurred. Therefore, PMHS neck forces and moments were only compared to the HIII and THOR-M for the KB condition. Neck injury risks were calculated for the HIII and THOR-M and were compared to the injuries observed for the PMHSs. Results: The HIII had greater upper and lower neck shear forces than the THOR-M, whereas both surrogates had similar upper and lower neck axial forces. The HIII also experienced greater peak upper neck bending moments than the THOR-M, which experienced negligible upper neck bending moments. Before head contact, the PMHSs experienced upper neck flexion, and the HIII experienced extension. The HIII and THOR-M injury risk curves predicted less than a 50% risk of an Abbreviated Injury Scale (AIS) 3+ injury. No AIS 3+ neck injuries were observed for the PMHS tests, but at least one AIS 2 injury was observed per condition. Conclusions: The results of this study showed that the HIII and THOR-M had different neck kinetics for these restraint conditions. In particular, the THOR-M experienced lower upper neck shear forces and bending moments. These differences are likely due to the very different neck designs of the anthropomorphic test dummies (ATDs), particularly the increased compliance of the THOR-M neck. Despite these differences, both ATDs still predicted a similar risk of AIS 3+ neck injury.
Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection and Other Conditions in Children: A Joint Position Paper From the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and N

Fecal microbiota transplantation (FMT) is becoming part of the treatment algorithms against recurrent Clostridium difficile infection (rCDI) both in adult and pediatric gastroenterology practice. With our increasing recognition of the critical role the microbiome plays in human health and disease, FMT is also being considered as a potential therapy for other disorders, including inflammatory bowel disease (Crohn disease, ulcerative colitis), graft versus host disease, neuropsychiatric diseases, and metabolic syndrome. Controlled trials with FMT for rCDI have not been performed in children, and numerous clinical and regulatory considerations have to be considered when using this untraditional therapy. This report is intended to provide guidance for FMT in the treatment of rCDI in pediatric patients.
Propensity-matched analysis of minimally invasive approach versus sternotomy for mitral valve surgery

Objective The objective of this multicentre study was to compare short-term and midterm outcomes between sternotomy and minimally invasive approaches for mitral valve surgery. Methods Data for all mitral valve procedures with or without concomitant tricuspid atrial fibrillation surgery were analysed from three UK hospitals between January 2008 and December 2016. To account for selection bias between minimally invasive approach and sternotomy, one-to-one propensity score calliper matching without replacement was performed. The main outcome measure was midterm reintervention free survival that was summarised by the Kaplan-Meier estimator and compared between treatment arms using the stratified log-rank test. Results A total of 2404 procedures (1757 sternotomy and 647 minimally invasive) were performed during the study period. Propensity score matching resulted in 639 matched pairs with improved balance postmatching in all 31 covariates (absolute standardised mean differences <10%). Despite longer procedural times patients who underwent minimally invasive surgery had a lower need for transfusion (20.5%vs14.4%, p=0.005) and reduced median postoperative length of stay (7 vs 6 days, p<0.001). There were no statistically significant differences in the rates of in-hospital mortality or postoperative stroke. Reintervention-free survival at 8 years was estimated as 86.1% in the minimally invasive group and 84.1% in the sternotomy group (p=0.40). Conclusions Minimally invasive surgery is associated with excellent short-term outcomes and comparable midterm outcomes for patients undergoing mitral valve surgery. A minimally invasive approach should be considered for all patients who require mitral valve intervention and should be the standard against which transcatheter mitral techniques are compared.
Plasmodium centrin PbCEN-4 localizes to the putative MTOC and is dispensable for malaria parasite proliferation

ABSTRACT Centrins are calmodulin-like phosphoproteins present in the centrosome and play an active role in the duplication, separation and organization of centrosomal structures such as the microtubule-organizing centre (MTOC) during mitosis. They are also major components of the basal body of flagella and cilia. In Plasmodium spp. , the parasite that causes malaria, mitosis is closed during asexual replication and the MTOC is embedded within the intact nuclear membrane. The MTOC has been named the centriolar plaque and is similar to the spindle pole body in yeast. In all phases of asexual replication, repeated rounds of nuclear division precede cell division. However, our knowledge of the location and function of centrins during this process is limited. Previous studies have identified four putative centrins in the human parasite Plasmodium falciparum. We report here the cellular localization of an alveolate-specific centrin (PbCEN-4) during the atypical cell division of asexual replicative stages, using live cell imaging with the rodent malaria parasite P. berghei as a model system. We show that this centrin forms a multi-protein complex with other centrins, but is dispensable for parasite proliferation. Summary: This study examines the localization of malaria parasite centrin PbCEN4 at the parasite MTOC during closed endomitosis and shows it to be dispensable for proliferation.
Detecting Structure In Chaos: A Customer Process Analysis Method

Detecting typical patterns in customer processes is the precondition for gaining an understanding about customer issues and needs in the course of performing their processes. Such insights can be translated into customer-centric service offerings that provide added value by enabling customers to reach their process objectives more effectively and rapidly, and with less effort. However, customer processes performed in less restrictive environments are extremely heterogeneous, which makes them difficult to analyse. Current approaches deal with this issue by considering customer processes in large scope and low detail, or vice versa. However, both views are required to understand customer processes comprehensively. Therefore, we present a novel customer process analysis method capable of detecting the hidden activity-cluster structure of customer processes. Consequently, both the detailed level of process activities and the aggregated cluster level are available for customer process analysis, which increases the chances of detecting patterns in these heterogeneous processes. We apply the method to two datasets and evaluate the results’ validity and utility. Moreover, we demonstrate that the method outperforms alternative solution technologies. Finally, we provide new insights into customer process theory.
Exploring the influence of resiliency on physician trust in patients: An empirical study of Chinese incidents

Background The tension in doctor-patient relationships is becoming progressively greater due to the high expectations of patients and the physicians’ work pressure. Recent studies have addressed factors which affect the tension of doctor-patient relationships, and our study continues this trend by looking at the influence of resiliency and physician trust in the patient (PTP), that is, how much the doctor trusts the patient. Methods Based on a survey of 329 physicians, a descriptive analysis of measured data was done using SPSS 19.0. Pearson correlation coefficient analysis was used to examine the correlation between PTP and resilience and the demographic variables. KMO and Bartlett methods were used to examine the correlation between PTPS and resilience. The method of factor analysis was used for multicollinearity tests, and multiple stepwise regression analysis was used to explore the demographic factors correlated with PTP and resilience. Result Our results indicate that the level of PTP is influenced by the age, education, and income of the doctors. Physician age and income are significantly and positively correlated with PTP, but education is significantly and negatively related. Age, education, and income also affect the level of psychological resilience of physicians. Resilience is positively correlated with age and education but is negatively related to income. Resilience positively influences PTP. Conclusion The direct factors of PTP include resilience, age, education, and income, while gender, title, and hospital department were found to be indirect influencing factors. To meet goals expressed in Chinese government policy related to these issues, we suggest improving the level of education of the doctors, providing reasonable annual salary increases for doctors, easing the tensions involved in medical treatment, reducing the physicians’ work pressure, improving the physicians’ work environment, and enhancing the physicians’ professional sympathy. Through such measures, the level of PTP will be enhanced.