Miracle-dz/UniFAR-FTUs huggingface dataset:
EFFECTS OF LOW LEVEL LASER THERAPY (LLLT) BIOSTIMULATION ON GCF LEVELS OF SCLEROSTIN IN SURGICAL MANAGEMENT OF INTRABONY DEFECTS

Aim: To evaluate the effects of low level laser therapy (LLLT) biostimulation following open flap debridement (OFD) and correlate with GCF levels of sclerostin in intrabony defect management. Materials and methods: 30 patients with 2 and 3 wall intrabony defects were treated using LLLT biostimulation along with OFD (n=15) and OFD alone (n=15). Patients were recalled at 3 and 6 months to assess the changes in sclerostin levels, Plaque index, Gingival index, Probing pocket depth, Clinical attachment level, Defect depth and gain in defect height. Results: Both test and control groups showed a statistically significant improvement in all clinical parameters, sclerostin biomarker levels and defect depth from baseline to 3 and 6 months. However, the test group had a statistically significant reduction in defect depth at 3 to 6 months and the sclerostin biomarker levels also showed a statistically significant correlation to defect depth at all-time intervals. Conclusion: Within limitations of the present study it can be concluded that LLLT has a greater benefit over OFD alone in intra bony defect regeneration as observed by progressive bone fill from 3 to 6 months.
Roux-en-Y gastric bypass as a cure of iatrogenic - steroid induced diabetes.

BACKGROUND Steroid-induced diabetes (SIDM) is a frequently found clinical condition since steroid-based therapies continue to be widely used in hospital and ambulatory care. Recommended optimal treatment of SIDM includes similar glucose lowering strategies as in type 2 diabetes. This typical management cannot cure the disease, it can only control blood glucose. Recently, bariatric surgery has emerged as an effective treatment for type 2 diabetes mellitus. However, up to now, the usefulness of bariatric surgery in treatment of SIDM has not been evaluated. CASE REPORT A 49-year-old female oncologic patient with steroid induced diabetes was referred for surgical treatment to the Department of General and Transplant Surgery in November 2009. Six years earlier, she underwent successful oncologic treatment with cladribine and high doses of steroids due to hairy cell leukemia. Finally complete hematologic remission with normalization of morphology and reduction of spleen size has been obtained. Prior to steroid treatment, blood glucose and urine examinations were within normal range. The patient was non-obese and had no family history of diabetes. Nevertheless, the patient developed diabetes secondary to corticosteroid therapy, poorly controlled by oral hypoglycemic agent (acarbosum), successfully converted to insulin therapy. Upon admission to the Department of General and Transplant Surgery, the patient was treated with 58 units of insulin per day. The patient was scheduled for Roux-en-Y gastric bypass (RYGB). Insulin was withdrawn immediately after the surgery and within six months after the surgery, plasma glucose and glycated hemoglobin (HbA1c-5.5%) levels reached and remained within normal range. Currently, eight years after surgery, body weight and BMI are 80 kg and 27.68 kg/m2, respectively. Plasma glucose and glycated hemoglobin are also normal. Importantly, from an oncological point of view, the patient has remained in continuous complete remission since October 2003. CONCLUSIONS Our report is the first to our knowledge describing the effect of gastric bypass surgery on SIDM in a patient with prior hematologic malignancy. It proves that surgically altered anatomy of the small intestine improves glucose homeostasis previously disturbed with pro-diabetic medication.
Factors and outcomes associated with paediatric emergency department arrival patterns through the day.

Introduction Steadily increasing emergency department (ED) utilization has prompted efforts to increase resource allocation to meet demand. Little is known about the distribution and characteristics of patient arrivals by time of day. This study describes the variability and patterns of ED resource utilization related to patient, acuity, clinical, and disposition characteristics over a 24-hour period. Methods Retrospective cross-sectional study of all visits to a tertiary children's hospital over a 1-year period. We use descriptive statistics to present ED visit details stratified by shift of arrival, and multivariable regression to explore the association between shift of presentation and hospital admission at index and 7-day return ED visits. Results Of 46,942 visits during the study period, 12% arrived overnight, 42% during the day, and 45% during the evening with variability in pattern of shift arrival by day of week. Overnight arrivals had a higher acuity (Canadian Triage and Acuity Scale [CTAS]) and different presenting complaints (more viral infection, less minor trauma) than day and evening arrivals, but similar ED length of stay. Shift of arrival was not associated with admission to hospital, but age, gender, socioeconomic status (SES), and day of week were. Discussion ED utilization patterns vary by shift of arrival. Though overnight arrivals represent a smaller proportion of total daily arrivals, their acuity is higher, and the spectrum of disease differs from day or evening arrivals. Conclusions Understanding variations and patterns of ED utilization by shift of arrival and day of week may be helpful in tailoring resource allocation to more accurately and specifically meet demands.
Word-to-meaning connection: a comparison between auditory and visual modalities in the first and second language

The present study examined the link between words and their semantic representations in two modalities, namely, the visual modality vs. the auditory modality. It compared the reaction times (RTs) of native vs. advanced-level non- native speakers of English on a word-picture matching task. The goal was to examine in which of the two modalities an L2 word can more quickly activate the target semantic representation. The participants were presented with one word at a time, each followed by either a matching or mismatched image. The task consisted in using a key on the keyboard to respond as quickly as possible to indicate whether or not the presented image matched the previously presented image. Word stimuli were presented either in auditory format (using a headset) or visually (a string of letters on the screen). The time taken from the word recognition phase to the matching image represents the time that it takes the perceptual system to activate the sematic representation of a given word. The results show that the link between an L1 word and its semantic representation is not significantly different in these two modalities. However, there is a statistically significant difference between the two modalities when a word is presented in the L2 (RT after the auditory modality was slower). The observed result might be due to the difficulty in matching an auditory-presented L2 word to its L2 phonological representation. This factor would cause a slower activation of the related semantic representation compared to the visually-presented words.
Indolent systemic mastocytosis mimicking Crohn’s disease

Mastocytosis is a rare and heterogeneous group of diseases whose common element is the presence of dense mast-cell infiltrates in various tissues. The gastrointestinal (GI) tract is frequently affected with vague and subtle manifestations, making the diagnosis of GI mastocytosis rather formidable and challenging. The diagnosis of the disease requires a high level of clinical suspicion and an index of familiarity. To our knowledge, this is the first case of indolent systemic mastocytosis with colonic ulcerations. Because of the unusual presentation of mastocytosis, it was initially misdiagnosed as Crohn’s disease; the diagnosis of mastocytosis was established after further evaluation of the patient’s history and further investigation. Systemic mastocytosis should therefore be considered in the differential diagnosis in patients presenting with abdominal manifestations that cannot be otherwise explained or attributed to common GI pathologies and in cases where the patient’s trajectory does not follow the expected course. More research is needed into the epidemiology and the non-classical presentation of systemic mastocytosis in order to increase awareness of the disease in the medical community.
The timing and composition of gestational weight gain and the impact on neonatal anthropometry

Fetal macrosomia is associated with a number of health complications for both mother and infant in the immediate, short, and long-term. Maternal obesity and excessive gestational weight gain (GWG) have long been associated with fetal macrosomia, however the impact of maternal lifestyle factors such as dietary intake and energy balance, in combination with the timing and composition of weight gain, have been less studied. It is also clear that although maternal obesity and excessive GWG increase the risk of fetal macrosomia independently, the risk is magnified with the presence of both risk factors, suggesting that interventions to control GWG may be particularly important for obese women. Association studies examining the relationship between fetal nutrient availability, epigenetic modifications, and infant anthropometrics are also required. This review provides an overview of the current evidence examining the role of maternal lifestyle factors on the prevalence of fetal macrosomia and identifies areas where further research is required in order to inform the design of appropriate intervention strategies.
Pruning Deep Convolutional Neural Networks for Fast Inference

Deep learning algorithms have recently achieved human level classification performance on several diverse classification benchmarks including object and speech recognition. However these algorithms are computationally very expensive especially for resource limited portable machines. Several researches have proposed ideas to lower this cost and in this dissertation, we have addressed this problem. We have proposed pruning and fixed-point optimization techniques to reduce the computational complexity of deep neural networks. Pruning is a promising technique where a problem is first approximated with a large sized network followed by removing unimportant parameters. The proposed work induces sparsity in a deep convolutional neural network (CNN) at three levels: feature map, kernels, and intra-kernel. Feature map pruning removes a large number of kernels and directly reduces the width of a layer and does not require any sparse representation. Thus the resulting network is thinner and runs faster than the predecessor unpruned network. However, feature map pruning removes all the incoming and outgoing kernels and thus affects a large number of parameters. We therefore may not achieve higher pruning ratios with feature map pruning. Kernel pruning eliminates k×k kernels and is neither too fine nor too coarse. It can change the dense kernel connectivity pattern to a sparse one. Each convolution connection involves W × H × k × k multiply and accumulate (MAC) operations where W, H and k represents the feature map width, height and the kernel size, respectively. Further the
Electronic Health Lifestyle Coaching Among Diabetes Patients in a Real-Life Municipality Setting: Observational Study

Background Internet and mobile interventions aiming to promote healthy lifestyle have attracted much attention because of their scalability and accessibility, low costs, privacy and user control, potential for use in real-life settings, as well as opportunities for real-time modifications and interactive advices. A real-life electronic health (eHealth) lifestyle coaching intervention was implemented in 8 Danish municipalities between summer 2016 and summer 2018. Objective The aim of this study was to assess the effects associated with the eHealth intervention among diabetes patients in a real-life municipal setting. The eHealth intervention is based on an initial meeting, establishing a strong empathic relationship, followed by digital lifestyle coaching and collaboration supported by a Web-based community among patients. Methods We conducted an observational study examining the effect of an eHealth intervention on self-reported weight change among 103 obese diabetes patients in a real-life municipal setting. The patients in the study participated in the eHealth intervention between 3 and 12 months. A weight change was observed at 6, 9, and 12 months. We used regression methods to estimate the impacts of the intervention on weight change. Results We found that the eHealth intervention significantly reduced weight among diabetes patients, on average 4.3% of the initial body mass, which corresponds to 4.8 kg over a mean period of 7.3 months. Patients who were in intervention for more than 9 months achieved a weight reduction of 6.3% or 6.8 kg. Conclusions This study brings forward evidence of a positive effect of a real-life eHealth lifestyle intervention on diabetes patients’ lifestyle in a municipal setting. Future research is needed to show if the effect is sustainable from a long-term perspective.
Psychosocial Aspects of Therapeutic Donor Insemination

The experience of delays in conception or possibility of remaining childless has the potential to create considerable psychological discomfort. In couples with severe male factor infertility, therapeutic intrauterine insemination using donor sperms (TDI) is offered as a treatment, second to in vitro fertilization using donor sperms. TDI is lucrative, less invasive, and a hopeful treatment. However, there are intricacies associated with it. Its immediate outcomes involve limited success rates, nonresponse, and chances of implantation failures, miscarriages, and multifetal pregnancies. Due to this, couples experience distress when they are advised to undergo three to six cycles of TDI in order to meet the expectations of having a baby. TDI has long-term issues on the triad comprising the “recipients,” the “donors,” and the “the children born out of TDI. ” Nevertheless, managing psychosocial needs for couples undergoing TDI and other treatments in Indian clinics are grey areas of the conventional treatment pathway. The present review expands on the psychological issues and needs in couples opting for TDI.
Computational Analysis of Theacrine, a Purported Nootropic and Energy-Enhancing Nutritional Supplement

Herein is the first reported conceptual density functional theory (DFT) investigation of the purine alkaloid theacrine and the comparison of quantum chemical properties to the closely related stimulant caffeine. DFT global chemical reactivity descriptors (chemical hardness/softness, chemical potential/ electronegativity, and electrophilicity) and local reactivity descriptors (Fukui functions and dual descriptor) were calculated for both compounds using Spartan ‘16 software. All calculations were carried out at the B3LYP/6-31G* level of theory. Reactivity analysis of the Fukui dual descriptor calculations reveals sites of nucleophilic and electrophilic attack. The results provide a solid chemical foundation for understanding how theacrine interacts with cellular systems.
AN ANALYSIS OF FLOUTING MAXIMS IN TONI MORRISON’S “BELOVED” (1987)

This thesis studies about flouting maxims in Toni Morrison’s “Beloved”. This study concerns on finding the flouting maxims in the novel and try to find the implicatures that caused by flouting the maxims. By using the descriptive qualitative method, the researcher tried to observe by using critical analyzing way for each conversation that occured in the novel. Each conversation in the novel is observing by considering if it is one kind of conversation that flouting the maxim of quality,quantity,relation or manner which are according to Grice theory about maxims. The setting of conversation in the novel is also take a part as the evidence if it is flouting maxims. Implicatures that caused by the speaker is also become one important element in order to check the effect of flouting maxim. It indicates that in Toni Morrison’s “Beloved”, occured flouting maxims, all of four maxims had been found in the conversation between the characters. Keywords :conversation, maxim, flouting maxims, characteristics
ANALISIS LITERASI MATEMATIKA SISWA KELASVII SMP DENGAN MODEL PBL PENDEKATANREALISTIC MATHEMATICS EDUCATION (RME)BERBANTUAN KARTU MASALAH

Rendahnya kemampuan literasi matematika di Indonesia dapat dikarenakan kurangnya penerapan pembelajaran yang inovatif, kreatif, dan realistik. Siswa tidak terbiasa menghadapi soal yang berkaitan dengan permasalahan sehari-hari. Penanaman kemampuan literasi matematika dapat dilakukan melalui proses pembelajaran yang mendukung. Penerapan model pembelajaran PBL pendekatan RME berbantuan Kartu Masalah diharapkan dapat meningkatkan kemampuan literasi matematika. Penelitian ini bertujuan untuk (1) mengetahui tercapainya ketuntasan klasikal pada kelas eksperimen, (2) mengetahui kemampuan literasi matematika dengan model PBL pendekatan RME berbantuan kartu masalah lebih baik daripada kemampuan literasi matematika kelas kontrol, (3) mengetahui peningkatan literasi matematika pada kelompok siswa yang mendapatkan pembelajaran PBL pendekatan RME berbantuan kartu masalah dan kelompok siswa yang mendapatkan pembelajaran ekspositori dengan menggunakan selisih nilai post-test dan pre-test, (4) mengetahui kualitas pembelajaran PBL pendekatan RME berbantuan Kartu Masalah berkategori minimal baik, (5) mengetahui kemampuan literasi matematika siswa yang mendapat pembelajaran model PBL pendekatan RME berbantuan kartu masalah, (6) menelaah dan mendeskripsikan kemampuan literasi matematika dan kesalahan siswa dalam mengerjakan soal berorientasi PISA. Penelitian ini merupakan kombinasi model concurrent embedded dengan kuantitatif dan kualitatif. Penelitian kuantitatif menggunakan pretestposttest control group design dengan pemilihan sampel secara random samplimg. Penelitian kualitatif menggakan purposive sampling. Populasi dalam penelitian ini adalah siswa kelas VII SMP Negeri 1 Selogiri tahun ajaran 2015/2016 dengan di mana siswa kelas VII C sebagai siswa eksperimen dan siswa kelas VII A sebagai siswa kontrol. Kedua kelas kemudian diuji untuk mengetahui kemampuan literasi matematika siswa setelah diberi perlakuan yang berbeda. Hasil penelitian ini menunjukkan bahwa rata-rata kemampuan literasi matematika siswa kelas eksperimen telah mencapai ketuntasan klasikal, peningkatan kemampuan literasi matematika siswa kelas eksperimen lebih baik daripada kelas kontrol, kualitas pembelajaran PBL pendekatan RME berbantuan Kartu Masalah yang dilaksanakan memiliki kategori sangat baik, kemampuan literasi matematika dengan model PBL pendekatan RME berbantuan kartu masalah tergolong cukup baik, kesalahan yang dialami siswa dalam mengerjakan soal berorientasi PISA pada umumnya adalah siswa melakukan kesalahan dalam transformation, prosess skill yang mengakibatkan kesalahan encoding juga karena kebanyakan siswa masih bingung dalam memahami soal dan menerapkan konsep matematika ke dalam permasalahan sehari-hari.
Surveying the factor structure and reliability of the Persian version of the Jefferson scale of physician empathy-health care provider student version (JSE-HPS)

Article type: Original Article Received: Aug. 2015 Accepted: Oct. 2015 Corresponding author: Ali Taghipour e-mail: TaghipourA@mums.ac. ir Background & Aim: Because of the importance of empathy and positive impact on the relationship between patients and health care providers, as well as the lack of valid instrument to assess student's empathy in health domain, this study aimed to examine the factor structure and reliability of the Persian version of JSE-HPS in the students of the School of Nursing and Midwifery, Mashhad University of Medical Sciences in Iran. Methods & Materials: In this cross-sectional study, 398 nursing and midwifery students of Mashhad University of Medical Sciences were selected using stratified random sampling. The data collection instrument was JSE-HP. The confirmatory factor analysis was used to investigate the factor structure of the instrument, and the Cronbach's alpha coefficient was applied to examine its reliability. The data analysis was done using LISREL version 8.8 and SPSS version 20. Results: The results of the confirmatory factor analysis model showed given that fitness model parameters, including CFI, GFI, AGFI and NFI were approximately 1 and RMSEA index was less than 0.1, the fitness of three-factor model is appropriate. The Cronbach's alpha coefficient for the total instrument was 0.63. Conclusion: The current study confirmed the three-factor structure of the Persian version of JSE-HPS (20 items), included perspective taking, compassionate care and standing in patient’s shoes. Thus, this instrument is appropriate to measure empathy for patient in the health service provider students.
Tissue factor expression is associated with recurrence in patients with non-metastatic colorectal cancer

Malignancy is a known pro-coagulant state, predisposing to thrombosis. A number of coagulation abnormalities have been reported to be associated with tumor growth, metastasis, and recurrence in different types of solid tumor including esophageal, gastric, pancreatic, ovarian, lung, and colorectal cancer [1-4]. Tissue factor (TF) is a transmembrane glycoprotein that has a central role in initiating the coagulation cascade [5,6]. TF expression has been identified immunohistochemically in epithelial tissues, specifically the skin, the mucosal surfaces of the gut, and genitourinary system [7]. However, it has also been found to be overexpressed in cancer cells. A direct association between elevated TF expression and advanced stages of malignancy has been confirmed in several different types of cancers [8-11]. More recent studies have suggested that TF expression contributed to metastasis by interfering with cell signaling pathways and presenting the proteolytic activity by the TF/ factor VI activated complex. Therefore, increased TF expression is associated with a worse oncologic outcome [12-14]. Fibrinogen, the most abundant plasma coagulation factor, is a key protein in coagulation pathway, clot formation, and wound healing, and is required for platelet aggregation, which is the final step in the coagulation cascade. It has previously been suggested that fibrinogen and platelets have a role in carcinogenesis, and their levels are associated with tumor progression, metastasis, and angiogenesis [15-17]. Furthermore, recent studies have shown that elevated fibrinogen plasma levels and platelet counts are a useful Original Article Korean Journal of Clinical Oncology 2018;14:128-134 https://doi.org/10.14216/kjco.18022 pISSN 1738-8082 ∙ eISSN 2288-4084
Kaedah-kaedah Tafsir Fi Zhilaali Al-quran

Meski tidak dipungkiri bahwa al-Quran telah diturunkan sejak berabad-abad lamanya di zaman Rasulullah Saw dan menggambarkan tentang kejadian masa itu dan sebelumnya sebagaimana yang terkandung dalam Qashash al-Quran, namun ajaran-ajaran yang dikandung dalam al-Quran adalah ajaran yang relevan yang dapat diterapkan di segala tempat dan zaman. Maka, tak salah jika kejadian-kejadian masa turunnya al-Quran adalah dianggap sebagai perjalanan sejarah umat manusia pada fase berikutnya. Dan tidak heran jika penafsiran-penafsiran yang telah diusahakan oleh ulama klasik perlu disesuaikan kembali dalam masa sekarang. Berangkat dari itu, Sayyid Qutb mencoba membuat terobosan terbaru dalam menafsirkan al-Quran yang berangkat dari realita masyarakat dan kemudian meluruskan apa yang dianggap tidak benar yang terjadi dalam realita tersebut.