Miracle-dz/UniFAR-FTUs huggingface dataset:
PTU-183 Advice from a dietitian regarding the low fodmap diet broadly maintains nutrient intake and does not alter fibre intake

Introduction Dietary restriction of certain fermentable carbohydrates (low FODMAP diet, LFD) is increasingly utilised for managing symptoms of irritable bowel syndrome (IBS). Exclusion diets carry a risk of nutritional inadequacy, and lower calcium intake has been reported during a LFD. Furthermore, it is important to understand whether the positive impact of the LFD is due to FODMAP restriction or an unintended dietary change (e.g. fibre intake). This single-blind randomised controlled trial aimed to compare nutrient intake in patients with IBS following LFD advice with baseline and a sham diet. Method Adult patients with IBS referred to a secondary care dietetic service were screened for inclusion (n = 162). Suitable patients who were following their habitual diet (baseline) were randomised to blinded LFD advice or sham (placebo) dietary advice provided by a registered dietitian. The sham diet was designed to be equivalent in nutrients and FODMAP content compared with baseline intake. A 7-day diet record was completed and weight recorded at baseline and 4 weeks. Mean daily nutrient intakes were calculated from diet records (excluding supplements) entered into dietary composition software (Dietplan 6, Forestfield Software Ltd). Comparisons were made with dietary reference values (DRVs). Data was analysed using t-tests and McNemar tests. Results A total of 95 patients completed the study (63 females, 66%) with 8 withdrawals and 1 lost to follow up (LFD n = 4, sham n = 5). Mean weight change was not different between groups (LFD -0.3 kg vs sham -0.4 kg, p = 0.738). There were no differences in mean energy and nutrient intakes, including calcium, between LFD and sham at baseline or follow up except vitamin B12at follow up (LFD 6.3 µg/d vs sham 4.7 µg/d, p = 0.004). There was a significant reduction in mean iron intake in LFD from baseline (11.3 mg/d) to follow up (10.2 mg/d, p = 0.008), although proportion of LFD meeting the iron DRV did not differ (baseline 52% vs follow up 48%, p = 0.375). Proportion of LFD meeting the fibre DRV did not change (baseline 53% vs follow up 53%, p = 1.00). Proportion of LFD meeting the calcium DRV at baseline was higher (64%) than after LFD (47%, p = 0.039). Overall, mean LFD nutrient intakes were similar to data for the healthy population. Conclusion More than half of patients following LFD advice did not meet DRVs for iron and calcium, although mean nutrient intakes were comparable to the healthy population. Energy and nutrient intake after LFD advice is not different to sham dietary advice, confirming that altered fibre intake is not responsible for its impact on IBS symptoms. Disclosure of interest None Declared.
Frozen-thawed gelatin-induced osteogenic cell sheets of canine adipose-derived mesenchymal stromal cells improved fracture healing in canine model

We assessed the efficacy of frozen-thawed gelatin-induced osteogenic cell sheet (FT-GCS) compared to that of fresh gelatin-induced osteogenic cell sheet (F-GCS) with adipose-derived mesenchymal stromal cells (Ad-MSCs) used as the control. The bone differentiation capacity of GCS has already been studied. On that basis, the experiment was conducted to determine ease of use of GCS in the clinic. In vitro evaluation of F-GCS showed 3–4 layers with an abundant extracellular matrix (ECM) formation; however, cryopreservation resulted in a reduction of FT-GCS layers to 2–3 layers. Cellular viabilities of F-GCS and FT-GCS did not vary significantly. Moreover, there was no significant difference in mRNA expressions of Runx2, β-catenin, OPN, and BMP-7 between F-GCS and FT-GCS. In an in vivo experiment, both legs of six dogs with transverse radial fractures were randomly assigned to one of three groups: F-GCS, FT-GCS, or control. Fracture sites were wrapped with the respective cell sheets and fixed with 2.7 mm locking plates and six screws. At 8 weeks after the operations, bone samples were collected and subjected to micro computed tomography and histopathological examination. External volumes of callus as a portion of the total bone volume in control, F-GCS, and FT-GCS groups were 49.6%, 45.3%, and 41.9%, respectively. The histopathological assessment showed that both F-GCS and FT-GCS groups exhibited significantly (p < 0.05) well-organized, mature bone with peripheral cartilage at the fracture site compared to that of the control group. Based on our results, we infer that the cryopreservation process did not significantly affect the osteogenic ability of gelatin-induced cell sheets.
Infant and Young Child Feeding – Knowledge and Practices of ASHA workers of Doiwala Block, Dehradun District

Introduction: Promotion and support of breastfeeding is a global priority and an important child-survival intervention. Accredited Social Health Activists (ASHAs) can play a significant role in the promotion of breast-feeding. Present research paper reviews their knowledge & practices with respect to Infant and Young Child Feeding (IYCF) issues. Further, it also analyzes difficulties being faced by them in promoting positive IYCF practices so that necessary support can be provided for carrying out their desired role. Material and Methods: It was a descriptive, cross-sectional study conducted in the block Doiwala of Dehradun district, Uttarakhand. All 168 ASHAs were included in the study for the assessment of knowledge and practices by interview technique based on predesigned and pre-tested questionnaire. Results: 98% ASHAs had complete and correct information about exclusive breast feeding, however only 38% ASHAs were aware that breastfeeding should be started within 4 hours in children delivered by caesarean section. Only 18% ASHAs reported to be able to motivate mothers to practice exclusive breast feeding. Insufficient mother’s milk (55.4%), Caesarean sections (20.2%), coercion from elders in the family to start top milk were among the important factors attributed for failure of exclusive breastfeeding. Regarding complementary feeding, only 45% ASHAs knew the correct timing of initiation of complementary feeding; however 58% ASHAs had introduced the complementary feeding at 7th month in their children. 83.9% ASHAs knew that complementary food should be semisolid in consistency, while 87.5% and 32.7% ASHAs were aware that egg and non-vegetarian food items can be given as complementary food to the child. Bottle feeding had been practiced by about 33% of ASHAs in the past; however no ASHA had reported bottle feeding currently. Conclusion: Present research paper concludes that although knowledge level of ASHAs is high regarding IYCF practices but it does not match with the actual practices. They require skill building especially in the area of breastfeeding options for working women as well as complementary feeding.
Kuwaiti College Students’ Learning Styles and Multiple Intelligences

The study was focused on discovering the dominant learning styles and multiple intelligences that were exhibited by English as a foreign language (EFL) Kuwaiti students at the College of Basic Education (CBE) in Kuwait. One aim of the study was to rank order their most dominant learning styles and multiple intelligences. Another aim was to draw implications for teaching strategies and study materials that suit the Kuwaiti students’ learning styles and multiple intelligences. Data collection utilized a data elicitation instrument divided into two parts: one on learning styles (Oxford, 1998), and one on multiple intelligences (Christison, 1998b). Part one of the instrument targeted the students’ learning styles and part two was focused on their multiple intelligences. The researchers employed the Excel software program to generate means, percentages, rankings, and standard deviations. Data analysis identified the dominant learning styles of Kuwaiti students which were dominated by a global learning style, followed by an intuitive style, then closure-oriented, and then a visual, and finally an extroverted learning style. As for multiple intelligences, the Kuwaiti students were mainly interpersonal, visual, kinesthetic, logical-mathematical, linguistic, naturalist, intrapersonal, and lastly musical. Implications for research were drawn for conducting further studies in other EFL settings in order to develop teaching techniques that accommodate students’ learning styles and multiple intelligences and to design teaching tasks and activities that further expand students’ existing learning styles and multiple intelligences.
Phosphate Balance on Peritoneal Dialysis

Hyperphosphatemia is an independent predictor of mortality in end-stage renal disease patients, and 40% – 50% of peritoneal dialysis (PD) patients have suboptimal control of serum phosphate. Systematically addressing this problem requires an understanding of phosphate balance on PD. The present review discusses the determinants of daily phosphate load and focuses on the factors influencing renal and peritoneal clearance of phosphate.
Direct Anterior Approach for One-Stage Bilateral Total Hip Arthroplasty in an ASA 3 Wheelchair-Dependent Woman

This case report involves a 79-year-old wheelchair-dependent woman with bilateral destructive coxarthrosis, requiring total hip arthroplasty (THA). Mobilization and transfers were unbearable due to the bilateral involvement of her hips. Performing unilateral THA would not be sufficient due to the coexisting pain from the contralateral side. Therefore, the decision was made to perform bilateral THA in one stage using the direct anterior approach (DAA). One-stage bilateral THA (1-SBTHA) using the DAA in ASA 3 patients is not previously described in the literature. The procedure was completed as planned, without any major perioperative complications. Eight weeks postoperatively, the patient was able to mobilize unaccompanied using a walker. She regained her mobility and independence. This outcome suggests that 1-SBTHA using DAA can be considered for disabling coxarthrosis in carefully selected ASA 3 patients. DAA is the superior approach for 1-SBTHA, due to decreased muscle damage leading to early mobilization with improved gait. Another benefit of DAA is that both hips can be draped simultaneously without repositioning the patient during the procedure.
DEXAMETHASONE INDUCED ALTERATIONS IN LIPID PEROXIDATION, ANTIOXIDANTS, MEMBRANE BOUND ATPASE IN WISTAR ALBINO RATS Research Article

Dexamethasone is a synthetic adrenocortical steroid used to treat inflammatory and autoimmune conditions. It acts as an anti-inflammatory and immunosuppressant. It is more potent than hydrocortisone. Dexamethasone is used to treat ulcerative colitis, psoriasis, arthritis, allergic disorders and breathing related problems. However dexamethasone therapy is associated with a variety of side effects, among which nephropathy is the major one. Recent studies have suggested reactive oxygen species and oxidative stress as a cause of drug nephrotoxicity. Therefore, this study was designed to elevate the effect of dexamethasone administration on wistar rats with reference to lipid peroxidation, antioxidants and membrane bound ATPase enzymes. The adult male wistar albino rats were randomly assigned into two groups: Group I animals treated as normal control and group II rats received dexamethasone (0.7mg/kg/body weight). The results showed an increase in the kidney and liver weight and the significant decrease in body weight were observed in dexamethasone treated rats compared to control rats. Lipid peroxidation and ATPase activities were increased on dexamethasone administration. On the contrary the levels of antioxidant enzymes were decreased compared to control. These data suggested that long term exposure to dexamethasone treatment will have a devastating effect on the kidney and liver functions due to the fact that it can induce the lipid peroxidation and disrupt many metabolic pathways.
Baseline (BL) radiographic characteristics and severe pulmonary hemorrhage (SPH) in bevacizumab (BV)-treated non-small cell lung cancer (NSCLC) patients (pt): Results from ARIES, an observational cohort study (OCS).

7619 Background: BV prolongs progression free and overall survival in advanced NSCLC pts. ARIES, a prospective OCS, evaluates BV clinical outcomes in a real world setting. Post hoc analyses from randomized controlled trials suggest location and cavitation as potential risk factors for SPH, a serious and often fatal adverse event (AE). ARIES presents a unique opportunity to independently evaluate BL tumor characteristics and correlate with SPH. Methods: Pts with advanced nonsquamous NSCLC on first-line chemotherapy and BV enrolled. No doses, regimens or assessments were prespecified. Data were collected electronically at BL and quarterly. SPH were reported expeditiously. BL CT scans were requested for all pts and reviewed by an independent review facility (IRF). Results: NSCLC enrollment completed 06/2009. As of 09/2009, 1,970 pts had median follow-up of 9.6 mo. The IRF reviewed BL scans of 1,881 pts; 1,470 (78%) had ≥ 1 BL measurable (meas) tumor (≥ 0.5cm) and 49% (718) were central; 67% had largest tumor.
Comparative efficacy of S-1 versus best supportive care in advanced hepatocellular carcinoma.

466 Background: S-1, an oral fluoropyrimidine derivative, has been shown to be clinically effective against hepatocellular carcinoma (HCC). We carried out a retrospective study to evaluate the efficacy of S-1, compared to best supportive care (BSC) in patients with advanced hepatocellular carcinoma. Methods: From 2009.12 to 2013.12, 32 cases of advanced hepatocellular carcinoma (the presence of extrahepatic metastasis or locally advanced disease not amenable to surgical resection or other locoregional therapies) were retrospectively analysed. 18 patients received S-1 (80 mg/m2/day, administered during days 1~14 and repeated every 21 days) and 14 patients received best supportive care (BSC). The time to progression (TTP), overall survival (OS) and safety were assessed. Results: 17 of 32 (53.1%) patients had metastatic disease, including the retroperitoneal lymph nodes (7 cases), lung (4 cases), supraclavicular lymph nodes (3 cases), abdominal wall (3 cases), brain (2 cases) and adrenal glands (2 cases). 12.
Perceptions of Barriers to Cardiovascular Risk Factors and Decision to Seek Treatment among Middle-aged Men with Acute Myocardial Infarction

Purpose: This study was designed to identify meaningful themes related to the recognition of lifestyle risk factors and barriers in seeking treatment following an acute event of first-time acute myocardial infarction. Methods: A methodological mixed method of thematic content analysis and a quantitative analysis was used. The sample consisted of 120 male patients out of 11 when lifestyle and psychosocial factors were included. From the interview data among the 70 patients delayed greater than three hours, thirty-five themes categorized into 12 main themes influenced the delayed decision which was identified according to personal-cognitive, socio-cultural, and contextual factors. Conclusion: Health care providers should consider these themes in designing individual interventions to make lifestyle changes and to facilitate more prompt decisions to seek care.
Patient profile and adverse incidents in a specialised inpatient psychotherapy unit in South Africa

Objectives: To describe the demographic and clinical profile of patients admitted to a specialised psychotherapy unit. Secondarily, to document adverse incidents and premature discharges, and examine possible associated variables. Method: The study is a retrospective review of clinical records of patients admitted to the Tara hospital psychotherapy unit during 2007 and 2008. Results: One hundred and eighty one patient files were reviewed. These patients were predominately white (80.7%), English speaking (63.5%) women (86.7%), with cluster B personality traits (74%). Mood disorders and substance use disorders were the most frequent Axis I diagnoses. There was high co-morbidity on both Axis I and Axis II. Thirty four patients refused hospital treatment (RHT) after having been admitted and there were 22 adverse incidents. After multivariate analysis, adverse incidents were most strongly associated with self-harming behaviour prior to admission and a history of substance use. Only self-injury was found to be associated with RHT. Conclusion: The study showed that the patients admitted to the Tara hospital psychotherapy unit did not reflect the demographics of the general Gauteng population. This confirms the need for further research regarding awareness and referral patterns of personality disorders with respect to the different ethnicities in South Africa. Adverse events during hospital admission may be reduced by establishing suitable protocols, or using an alternative setting for treatment of patients with self-injury.
Increased Oxidative Stress, Loop Gain And The Arousal Threshold Are Clinical Predictors Of Increased Apnea Severity Following Exposure To Intermittent Hypoxia

Purpose We determined if oxidative stress prior to sleep onset is correlated to loop gain (LG) and the arousal threshold (AT) during non‐rapid eye movement (NREM) sleep. We also explored if LG and AT are correlated with apnea severity and indices of upper airway collapsibility during NREM sleep. Methods Thirteen male participants with obstructive sleep apnea (apnea–hypopnea index > 5 events/hr) were administered an antioxidant or placebo cocktail while exposed to mild intermittent hypoxia in the awake state. Thereafter, loop gain and measures of arousal, apnea severity and upper airway collapsibility were ascertained during NREM sleep. Results Modification in oxidative stress (i.e., 8-hydroxy-2-deoxyguanosine) prior to sleep onset was correlated to LG (r = 0.8, P = 0.003), the number (r = 0.71, P = 0.01) and duration (r = 0.63, P = 0.04) of apneic events and the percentage of time breathing was stable (r = −0.66, P = 0.03) during sleep. Using a forward stepwise regression analysis, our results showed that LG, AT, the ventilatory response to arousal and nadir end-tidal carbon dioxide were determinants of the apnea–hypopnea index (P value range = 0.04–0.001). In addition, the AT was a predictor of measures of upper airway collapsibility, including the hypopnea/apnea + hypopnea ratio and the degree of flow reduction that accompanied hypopneic events (P < 0.001). Conclusion Modifications in oxidative stress following exposure to intermittent hypoxia during wakefulness are positively associated with loop gain and apnea severity during NREM sleep. Moreover, an increase in the arousal threshold is a predictor of increased upper airway collapsibility.
Expression and localization of MYH11 in mouse tissues, oocytes and preimplantation embryos

Myosin heavy chain 11 (MYH11), a member of the myosin family, is an actin-based cytoskeletal motor protein. Limited previous studies have revealed that the Myh11 gene is expressed in cumulus cells, cumulus-oocyte complexes, and ovarian theca cells. However, its expression profiles in mouse tissues, oocytes and preimplantation embryos are largely unknown. Here, we found that the MYH11 protein was expressed in multiple mouse tissues. In the ovary, the MYH11 protein was highly expressed in oocytes and smooth muscle fiber cells. After ovulation and fertilization, Myh11 mRNA expression had sharply declined in zygotes and could not be detected from 8-cell to blastocyst stages, while the protein persisted until the blastocyst stage. Furthermore, the MYH11 protein was localized in the cytoplasm of oocytes and preimplantation embryos. These results provide the first evidence that MYH11 is enriched in oocytes and early embryos and might play a key role in oogenesis and early embryogenesis of mice.
A Cascaded Convolutional Neural Network for Assessing Signal Quality of Dynamic ECG

Motion artifacts and myoelectrical noise are common issues complicating the collection and processing of dynamic electrocardiogram (ECG) signals. Recent signal quality studies have utilized a binary classification metric in which ECG samples are determined to either be clean or noisy. However, the clinical use of dynamic ECGs requires specific noise level classification for varying applications. Conventional signal processing methods, including waveform discrimination, are limited in their ability to remove motion artifacts and myoelectrical noise from dynamic ECGs. As such, a novel cascaded convolutional neural network (CNN) is proposed and demonstrated for application to the five-classification problem (low interference, mild motion artifacts, mild myoelectrical noise, severe motion artifacts, and severe myoelectrical noise). Specifically, this study finally categorizes dynamic ECG signals into three levels (low, mild, and severe) using the proposed CNN to meet clinical requirements. The network includes two components, the first of which was used to distinguish signal interference types, while the second was used to distinguish signal interference levels. This model does not require feature engineering, includes powerful nonlinear mapping capabilities, and is robust to varying noise types. Experimental data are composed of private dataset and public dataset, which were acquired from 90,000 four-second dynamic ECG signals and MIT-BIH Arrhythmia database, respectively. Experimental results produced an overall recognition rate of 92.7% on private dataset and 91.8% on public dataset. These results suggest the proposed technique to be a valuable new tool for dynamic ECG auxiliary diagnosis.
User Assessment of "InsuOnLine," a Game to Fight Clinical Inertia in Diabetes: A Pilot Study.

Abstract Objective: We performed a pilot study to assess usability and playability of “InsuOnLine,” a serious game for education of primary care physicians on insulin therapy for diabetes mellitus. Materials and Methods: A multidisciplinary team has designed and developed “InsuOnLine,” using Andragogy and Problem-Based Learning principles, with game elements to improve players' motivation. The prototype was tested by four medical doctors and two medical students, using the System Usability Scale (SUS) and a questionnaire to assess playability. These results were used to guide corrections, after which the beta version was retested by 14 medical students and 6 residents. Results: Out of a maximum score of 100 on the SUS, the “InsuOnLine” prototype was rated 88, and some areas for improvement were identified (game instructions, controls). After corrections, the beta version was rated 92.5 on the SUS. Users have found the beta version to be fun, engaging, challenging, relevant, and realistic. Users said that .
Psychopathology among Female Breast Cancer Patients

Breast cancer is the second most common malignancy in women and second leading cause of cancer death in women. Like all chronic illnesses breast cancer also involves a series of threats and difficulties, which further lead to the development of mental problems in the patients. The present study is a venture to unfold the psychopathological profile of breast cancer patients. A sample of 140 breast cancer female patients aged 20 to 65 years was taken from the patients undergoing treatment in Rajiv Gandhi Cancer Institute and Research Centre, Delhi. The selected subjects were tested with Personality Assessment Inventory (PAI) and an interview was also conducted. The obtained data were processed by employing Product Moment Correlation, and Principal Component Factor Analysis. Factor analysis yielded five varimaxly rotated factors identified as (1) Subjective Somatic Distress and Affective Disruption; (2) Objective Distress; (3) Social Detachment,; (4) Dominance, and (5) Alcohol Abstinence. Extracted factors have accounted for 70.77% of total variance. These factors and contents of interview have revealed significant information about the psychopathology and other behavioural problems, the patients develop after being diagnosed for breast cancer.