Miracle-dz/UniFAR-FTUs huggingface dataset:
Surveillance of neutralization antibody to Japanese encephalitis virus in healthy population in Tongchuan city,Shaanxi province

Objective To understand Japanese encephalitis virus(JEV) antibody level in the healthy population in Tongchuan,and provide scientific evidence for the prevention and control of Japanese encephalitis.Methods Totally 216 healthy people in 7 age groups(≤2,3-5,6-10,11-15,16-45,46-60 and60 years old) were sampled by cluster random sampling in Yijun county of Tongchuan,and blood samples were taken from them to detect neutralization antibody(NA) to JEV by micro neutralization test.Results The positive rate of JEV NA(GMT) was 24.07%(1∶3.04) in the healthy population in Tongchuan.The positive rate(GMT) in age group ≤2 years old was highest(63.33%,1∶11.06),the positive rates and GMT in other age groups ranged from 6.45% to 31.03% and from 1∶1.78 to 1∶3.95 respectively.The differences on antibody levels between different age groups were statistical significant.Conclusion The JEV antibody positive rate and GMT were relatively low in the healthy population in Tongchuan,which might facilitate the epidemic of Japanese encephalitis.It is necessary to strengthen the Japanese encephalitis vaccination to increase the vaccination coverage.
Acne and Quality of Life- A Study from a Tertiary Care Centre in South India

Objectives: Acne vulgaris is a chronic disease affecting the face in adolescents and adults. It has considerable psycho-social impact on Health Related Quality of Life (HRQOL). The aim of our study is to assess the impact of acne on Quality of Life. Material and Methods: The study sample consisted of 483 consecutive patients with facial acne vulgaris. Patients who had attended the Dermatology OPD of Dr.Pinnamaneni Siddhartha Institute of Medical Sciences between November 2012 to March 2013 were included in the study. After obtaining the history, the acne was graded into mild, moderate and severe based on the type and number of lesions. Dermatology Life Quality Index(DLQI) and Cardiff Acne Disability Index(CADI) were administered on the patients to measure the Quality of Life. Results: Majority (53.2%) of the study population were betweeen16-20 years and the number of males was more than the number of females. Most of the patients were educated and unmarried.61. 4% of patients belonged to the urban areas & (60.04%) had an acne duration of >1 year. Severe acne was seen in 30.64% of patients and 50.35% had a moderate grade of acne. In 333 patients (68.94%) the CADI scores were >8 showing a clear impact on QOL. Based on the DLQI scores 75.1% of the patients had a moderate to extremely large impairment of QOL. Conclusion: Acne has an impact on Quality of Life (QOL) and evaluation of Quality of Life helps in the better management of patients with acne.
A Comparison of a Stereographic 3-D Display versus a 2-D Display Using an Advanced Air-to-Air Format

This study compared the relative abilities of a stereoscopic 3-D display versus a conventional 2-D display to provide spatial location information. The evaluation was conducted as a part mission, full-task simulation in the context of an air-to-air fighter mission. A dual task paradigm was employed requiring the subjects to acquire situation awareness of their immediate air-to-air environment while simultaneously performing a simple flight task. Situation awareness was defined as the ability to visually search a spatial quadrant of the air-to-air situation display relative to the ownship symbol and identify the number of aircraft symbols in a given target group found in that quadrant. The simulated flight task was a two-axis tracking task on a dynamic Head-Up Display format, using a force-stick controller. The subject's response speed and accuracy on the search task and deviations from the given track on the flight task were used as performance measures in this study. The results showed a significant accuracy performance advantage for those formats presented with the stereoscopic 3-D display.
Therapeutic adherence in outpatients with heart failure registered with a community pharmacy

Realizou-se estudo descritivo transversal, de acordo com a classificacao de adesao a terapeutica, para avaliar a adesao em 250 pacientes com diagnostico de disfuncao cardiaca, registrada no departamento de saude do municipio de Santiago de Cuba, em 2009. A caracterizacao da amostra foi estudada, com a avaliacao do nivel de adesao e possiveis fatores associado a sexo, idade e habitos toxicos. Como instrumento para o trabalho, esquematizou-se aa extracao de dados e realizou-se a entrevista nas moradias dos pacientes. Os resultados foram expressos em porcentagem e em nivel de influencia dos fatores associados, determinados por meio do teste do Q quadrado. Na populacao sob investigacao, a adesao foi maior para as mulheres da faixa etaria de 67 a 82 anos, e os habitos toxicos foram prevalentes. Na amostra em estudo, as farmacoterapias predominantes foram digoxina, clortalidona, captopril e dinitrato de isossorbida e se observou alto nivel de adesao tanto para os tratamentos farmacologicos quanto para os nao-farmacologicos. Observou-se alto nivel de adesao para 63,6% dos pacientes, nivel regular para 32% 3 somente 4,4% dos pacientes apresentaram baixa adesao. Os fatores que influenciaram foram conhecimento a respeito do tratamento, numero de medicamentos, frequencia de administracao e satisfacao com o servico de atencao farmaceutica.
A Low-Complexity I/Q Imbalance Calibration Method for Quadrature Modulator

This brief presents a low-complexity I/Q (in-phase and quadrature components) imbalance calibration method for the transmitter using quadrature modulation. Impairments in analog quadrature modulator have a deleterious effect on the signal fidelity. Among the critical impairments, I/Q imbalance (gain and phase mismatches) deteriorates the residual sideband performance of the analog quadrature modulator degrading the error vector magnitude. Based on the theoretical mismatch analysis of the quadrature modulator, we propose a low-complexity I/Q imbalance extraction algorithm. After the parameter extraction, the transmitter is calibrated by imposing the counter imbalanced mismatch of the transmitter through the digital baseband. In comparison with existing I/Q imbalance calibration methods, the novelty of the proposed method lies in that: 1) only three spectrum measurements of the device-under-test are needed for extraction and calibration of gain and phase mismatches; 2) due to the blind nature of the calibration algorithm, the proposed approach can be readily applicable to an existing I/Q transmitter; 3) no extra hardware that degrades the calibration accuracy is required; and 4) due to the noniterative nature, the proposed method is faster and computationally more efficient than previously published methods.
Estimation of the efficacy of seasonal influenza vaccine : vaccine development, statistical modelling and trial design

Influenza is an infectious seasonal disease against which yearly vaccination is recommended, especially for high risk populations. For a new vaccine, efficacy is classically assessed in large phase III trials. Unfortunately, in the past years, many trials have led to unexpected results. This work first aims to identify the particularities of the context of influenza with regards to the vaccine development. We confirm the link between post vaccination antibody response and vaccine efficacy without being able to identify an absolute threshold of protection. Combining simulations and analytical results, we then substantiate the limits of the actual statistical regression models used to estimate vaccine efficacy. To reach this goal, we had to develop a simulation framework for the generation of phase III clinical trials time-to-infection data. Our methodology brings together particularities of influenza and other infectious diseases as well as historical data. Finally, we propose a new methodology for the assessment of vaccine efficacy, taking into account the effect of strain heterogeneity on vaccine efficacy. By using hierarchical modelling and predictive intervals, we provide better insight on the range of future VE across seasons and geographical regions.
Typeface persona: a review study

Practitioners and scholarly researchers agree that different typefaces have different personas. Document design, which is largely dependent on the use of different typefaces, stems from the content of the verbal text and the purpose of the text is expressed through typography. In an age of electronic information set in microcosmic structure, possibilities we have come to face present freedom to modify and manipulate visual attributes of a document with software packages. This practice has given the opportunity to many untrained people to become publishers and active users of type and often times this practice is directed without understanding the principles of document design and the very notion of the intended perception of type’s persona. The relevance of typeface persona is an important aspect of technical or any other document that has its intended audience. Therefore, by choosing the appropriate typeface, communicators can determine the visual tone and character of the text. This paper outlines the visual rhetoric and consequently the role of typography as a part of that rhetoric. The literature review concentrates on typeface persona in theory, practice and research, exploring the idea of ‘’atmosphere’’, connotative meaning and semantic quality of type. The paper concludes with a discussion of the demand in the field of practitioners to classify typefaces according to their persona.
Does Sex Predict the Development of Mediastinitis

Objectives: We aimed to analyze whether sex was a risk factor for the development of mediastinitis after cardiac surgery. Methods: Literature screening was performed using PubMed database without date limitation. Trial results were evaluated with random or fixed-effect model according to the heterogeneity. Statistical evaluation was performed. Results: In total, 4044 articles were obtained after database searching. Of all these articles, 32 articles containing 1.11. 303 patients, which satisfied the inclusion criteria, were included in the meta-analysis. The rate of mediastinitis was 2.19%. The effect size was observed as heterogeneous (Q: 89.09, df(Q): 31, p:0.00, I2:65.20%). Analysis results according to the random effect model were as follows: OR (odds ratio), 1.09; 95% CI, 0.90–1.32; and p=0.34 (p>0.05). Conclusion: The results of the quantitative analysis showed that a patient’s sex does not predict the development of mediastinitis after cardiac surgery for children and/or adults.
The Role of Interleukin (IL)-22 as a Pro-Inflammatory Cytokine in Systemic Lupus Erythematosus

Background: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by multiple organ damage in addition to amounts of autoantibodies generated by excessively activated B cells, abnormal T cell subsets and related cytokines are also involved in the pathophysiology of SLE. Interleukin (IL)-22 is a cytokine that is important for the modulation of tissue responses during inflammation. IL-22 has both pro-inflammatory and tissue-protective properties, therefore this study aimed to assess the role of IL-22 levels in plasma of patients with SLE and compare it with normal controls. Also to correlate plasma levels of IL-22 with disease activity using systemic lupus erythematosus score (SLEDAI) in SLE patients. Subjects and Methods: Thirty five SLE patients (Group I) were subjected to full history taking and clinical examination, assessment of SLEDAI, laboratory investigations in the form of serological markers for systemic lupus activity, including anti-double stranded deoxyribonucleic acid (anti-ds DNA), anti-nuclear antibodies (ANA), and autoimmune profile complement components C3 and C4 levels, CBC, ESR, ALT, AST, blood urea nitrogen (BUN), serum and urinary creatinine and urinary protein, in addition to 40 age and sex matched healthy controls (Group II). Plasma IL-22 level using ELISA technique was done to all participants. Results: The plasma levels of IL-22 in SLE patients were significantly higher than normal controls with evidence of positive correlation between IL-22 levels and SLEDAI score. Conclusively, it could be suggested that the IL-22 may be implicated in the pathogenesis of SLE disease.
Dynamic Topic Adaptation for Improved Contextual Modelling in Statistical Machine Translation

In recent years there has been an increased interest in domain adaptation techniques for statistical machine translation (SMT) to deal with the growing amount of data from different sources. Topic modelling techniques applied to SMT are closely related to the field of domain adaptation but more flexible in dealing with unstructured text. Topic models can capture latent structure in texts and are therefore particularly suitable for modelling structure in between and beyond corpus boundaries, which are often arbitrary. In this thesis, the main focus is on dynamic translation model adaptation to texts of unknown origin, which is a typical scenario for an online MT engine translating web documents. We introduce a new bilingual topic model for SMT that takes the entire document context into account and for the first time directly estimates topic-dependent phrase translation probabilities in a Bayesian fashion. We demonstrate our model’s ability to improve over several domain adaptation baselines and further provide evidence for the advantages of bilingual topic modelling for SMT over the more common monolingual topic modelling. We also show improved performance when deriving further adapted translation features from the same model which measure different aspects of topical relatedness. We introduce another new topic model for SMT which exploits the distributional nature of phrase pair meaning by modelling topic distributions over phrase pairs using their distributional profiles. Using this model, we explore combinations of local and global contextual information and demonstrate the usefulness of different levels of contextual information, which had not been previously examined for SMT. We also show that combining this model with a topic model trained at the document-level further improves performance. Our dynamic topic adaptation approach performs competitively in comparison with two supervised domain-adapted systems. Finally, we shed light on the relationship between domain adaptation and topic adaptation and propose to combine multi-domain adaptation and topic adaptation in a framework that entails automatic prediction of domain labels at the document level. We show that while each technique provides complementary benefits to the overall performance, there is an amount of overlap between domain and topic adaptation. This can be exploited to build systems that require less adaptation effort at runtime.
Incidence of Primary Exercise Headache in Resistance Trained Athletes

Objectives: The aim of this study was to examine the incidence and patterns of primary exercise headache (PEH) in resistance trained male athletes. PEH is observed particularly during or after severe physical exercise and lasts up to 48 hours. While the focus of the literature has mainly been on the prevalence of PEH in the general population, few studies on athlete populations have been conducted so far. Therefore in a cohort study we examined the incidence and patterns of PEH in resistance trained athletes in an Iranian male sample. Methods: Apopulationof 116resistancetrainedathletes,between14to63yearsold,wasrecruited. PEHwasidentiﬁedintheathletes according to a questionnaire based on the 3rd international classiﬁcation of headache disorders. The athletes were followed up for six months on a monthly basis while the incidence, pattern and risk factors of PEH were evaluated in them in a precise manner. Results: The incidence of PEH in overall participants was evaluated 4.8 in 1000 hours exercise. The prevalence of headache during the follow-ups was 19.8% in which the highest headache incidence occurred in 20-30 years old athletes. PEH mainly occurred after sportsandthequalityof PEHwasmainlyasudden(81%)pulsating(47%)headachewhichwasfeltmostlyintheoccipitalregion(39%). The incidence of PEH had a strong statistical correlation with having a history of PEH (odds: 3.8; 95% CI: 1.02 - 14.3). Conclusions: Our study showed that incidence and prevalence of PEH in resistance trained athletes might be higher than general population. History of PEH was the main risk factor for developing PEH in resistance trained athletes.
Real-time hand gesture telerobotic system using fuzzy c-means clustering

This paper describes a teleoperation system in which an articulated robot performs a block pushing task based on hand gesture commands sent through the Internet. A fuzzy c-means clustering method is used to classify hand postures as "gesture commands". The fuzzy recognition system was tested using 20 trials each of a 12-gesture vocabulary. Results revealed an acceptance rate of 99.6% (percent of gestures with a sufficiently large membership value to belong to at least one of the designated classifications), and a recognition accuracy of 100% (the percent of accepted gestures classified correctly). Performance times to carry out the pushing task showed rapid learning, reaching standard times within 4 to 6 trials by an inexperienced operator.
Selection of a High Risk Group and the Effectiveness of an Exercise Program on Musculoskeletal Symptoms in Small and Medium Sized Enterprises

O b j e c t i v e s: This study was conducted to provide data for the establishment of a practical and the effective exercise program for managing the musculoskeletal symptoms of workers who are employed in small and medium sized enterprises. Methods: The risk factors related to musculoskeletal disease management were chosen according to the relevant literatures, and were based on advise from experts on the Delphi method. Questionnaires on selected risk factors (with a 5-point Likert scale) were given to 785 subjects who worked in small and medium sized enterprises. The subjects were then classified in the risk group when they had the symptoms and recorded at least 3 points. From those subjects in the risk group, those who had both work-related factors and general characteristics factors (with an average of at least 3 points) were further classified as the high risk group. We performed a 12-week musculoskeletal exercise program for the low and high risk groups to analyze their changes in symptoms and complaints in order to estimate the effectiveness of the exercise program. R e s u l t s: Out of 785 subjects, 454(57.8%) were in the risk group of musculoskeletal diseases and 121(15.4%) were in the high risk group. According to multiple logistic regression analysis of the factors for the musculoskeletal symptoms in the low risk group, the significant risk factors were sex and personal disease related with musculoskeletal disease, while the risk factors in the high risk group were age, sex, and personal disease related with musculoskeletal disease. After the 12-week exercise program was performed by the low risk group, the number of musculoskeletal symptom complaints in the control group did not significantly changed, whereas for the intervention group, the number of musculoskeletal symptom complaints significantly declined for all parts of the body. After the 12-week exercise program performed by the high risk group, the number of musculoskeletal symptom complaints in the control group was significantly enhanced for the arm and elbow parts. In the intervention group, the complaint rate for musculoskeletal symptoms significantly declined only for the low back. Conclusion: The musculoskeletal symptoms were significantly improved by the exercise program in the low risk group, but not in the high risk group. It is suggested that control measures on administrative and/or work related factors, in addition to the exercise program should be considered simultaneously for the control of musculoskeletal symptoms in groups at high risk of musculoskeletal disease.
ACCESSIBILITY: CONCEPTS AND APPLICATIONS

The character of accessibility as measuring the situation of a location in a region rather than its intrinsic qualities is emphasized throughout this paper. A brief characterization lays the basis for a sketch of data requirements, a specification of operational definitions, and a review of earlier findings. The idea of accessibility under competition is developed with several formulations, which are then compared through a synthetic example. Concluding comments suggest some guidelines and future directions.
A Multi Echelon Location-Inventory Model with Lateral Transshipment

In this research, a supply chain system consisting producer, distribution centers and retailers is modeled by considering lateral transshipment between distribution centers and also using echelon-based inventory system instead of independent inventory system. The model is developed in the form of mixed integer non-linear programming (MINLP) to minimize the total location, transportation, and inventory costs of the system. The model was solved using conic programming approach and validity was examined by comparing the developed model with the basic model (i.e. the model without the contributions) in several instances with different sizes of distributors and retailers. The results represent superiority of the developed model in computational time and objective value especially in medium and large-scale problems.
Current Trends in Peritoneal Dialysis

Starting 2011, CMS decided that there will be one payment for dialysis treatments regardless of whether the treatment is PD or HD, and whether performed at home or in a dialysis center. PD is the least expensive form of dialysis therapy due to several reasons. The supplies for PD are less expensive and it is less labor intensive for nurses; the patient and family providing the majority of labor. Also, fewer parenteral medications are given to PD patients than to HD patients, given the more convenient oral route of administration and the lack of a permanent intravenous access. Third, significantly lesser and lower dosages of ESAs are given to PD patients due to a more efficient ESA response(likely due to increased marrow response and subcutaneous dosing), preserved residual renal function, and less blood loss (no obligate HD loss). However, under the previous payment structure the larger “separately billables” portion of billing for injectable drugs given at HD served as a profit for dialysis providers, who took advantage of the spread between acquisition costs and payment rate. The percentage of profits of some dialysis chains solely from the use of ESAs was a staggering 20% of the total profits. This provider dependence upon separately billable services had perhaps impeded the use of less costly PD, accounting for its decline as a renal replacement therapy in the USA [1,2].
Clinical Significance of HOX11L2 and HOX11 Gene Expression in T-ALL Patients

Objective: The aim of this study was to determine the prognostic value of two structurally related homeobox genes TLX1/HOX11 and TLX3/HOX11L2 on the clinical outcome of T-ALL patients. Material and Methods: The study included 28 newly diagnosed T-ALL patients. HOX11L2 and HOX11 gene expression were detected by real time PCR. Patients received treatment according to the ALL BFM-90 protocol. Results: Of 28 patients, 8(28.6%) expressed HOX11L2 and 4(14.3%) expressed HOX11.The overall survival of patients with HOX11L2 expression was lower than of the patients without HOX11L2 expression (log-rank P<0.025). As regards HOX11 expression, a statistically significant difference in clinical outcome was found, where HOX11 expression conferred a prognostic advantage (p< 0.001). Conclusion: the present study was showed that the outcome of HOX11L2 and HOX11 expression differs, with poor outcome for patients with HOX11l2-expression. Future molecular diagnostics may make use of such leukemia-specific markers as HOX11L2 and HOX11 to detect minimal residual disease.