Miracle-dz/UniFAR-FTUs huggingface dataset:
Ki-67 Expression in Gingival Overgrowth: An Immunohistochemical Study

Ki-67 is a well-recognized nuclear proliferation marker. Considering that an unusual cell proliferation may have a role in the pathogenesis of gingival overgrowth with different etiologies. The study involved 4 patients with cyclosporine induced gingival overgrowth (CGO), 6 patients with phenytoin induced GO (PGO) and 5 patients with hereditary gingival fibromatosis (HGF). Healthy tissue samples without clinical signs of periodontal inflammation were also included as control samples. Immunohistochemistry against the proliferation antigen Ki-67 was performed and optical density measured and compared in both epithelium and connective tissue. Ki-67 was expressed both in the epithelium and corium of the four studied groups. The expression patterns of Ki-67 were significantly higher (p<0.00) in CGO, while no significant difference between HGF and PGO groups was detected and both showed lower values than CGO. Control group showed the significantly lowest mean of Ki-67 level and the expression was mainly in the basal layer of epithelium. In conclusion; increased cell division may have a role in the pathogenesis of gingival overgrowth induced by cyclosporine and phenytoin or inherited as HGF as reflected by increased expression of Ki-67. (Eman Y. El-Firt and Dalia M. Ghalwash Ki-67 Expression in Gingival Overgrowth: An Immunohistochemical Study) Life Science Journal,. 2011;8(4):221-226) (ISSN:1097-8135). http://www.lifesciencesite. com .
Effect of Plantar Flexor and Dorsiflexor Fatigue on Unilateral Postural Control

The purpose of this study was to determine the effect of plantar flexor and dorsiflexor fatigue on postural sway amplitude during unilateral, or one-legged, stance. It was hypothesized that plantar flexor and dorsiflexor fatigue would increase unilateral postural sway amplitude. Eight uninjured male subjects participated in pre- and postfatigue unilateral stability tests. Selected parameters describing medial-lateral (ML) and anterior-posterior (AP) postural sway were measured on a Chattecx Balance System before and after an isokinetic fatigue protocol. The fatigue protocol resulted in a significant increase in ML postural sway amplitude (p < 0.05) and an increase in AP sway amplitude (p = 0.065). Previously, links have been established between increased postural sway amplitude and ankle joint injury. Thus, fatigue of the plantar flexors and dorsiflexors, which increased postural sway amplitude, may render the ankle joint susceptible to injury. Induced ankle muscle fatigue may represent a valid paradigm t.
SURFACE AERATION FOR WATER TREATMENT AGITATED TANK MIXING TIME , POWER CONSUMPTION AND HYDRODYNAMICS

A surface aeration and agitation system used for water treatment was studied under both aerated and non-aerated conditions to explain the influencing parameters on the mixing time. The power consumption measurement and lower propeller pumping capacity by applying (LDV) are performed. A dimensionless mixing time number model is made to correlate the most affecting factors for the system.
The transmutation of dwarf galaxies: stellar populations

Transition-type dwarf (TTD) galaxies share characteristics of early-and late-type dwarfs. Thus, they are suspected to be the thread that connects them. We selected 19 TTD galaxies in the nearby Universe (cz < 2900 km s(-1)) from the Sloan Digital Sky Survey. They span the luminosity range from similar to-14.5 to -19.0 mag in the B band, and are located in different environments. We derive their single stellar population parameters and star formation histories, using the full spectrum fitting technique with two independent population synthesis models. Irrespective of the synthesis models, we find that these dwarfs have a relatively young mean age (around 1-2 Gyr) and low metallicities (similar to-0.7 dex). Moreover, they had approximately constant star formation rates until a few Gyr ago, associated with strong metal enrichment during the first few Gyr of their evolution. We compare these results with the results from Koleva et al., who studied dwarf elliptical (dE) galaxies in the same luminosity range. We find that (1) both samples occupy the same region in the luminosity-metallicity relation, (2) the build-up of the stellar mass in both types of galaxies is very similar, with most of the stars already formed 5 Gyr ago and (3) contrary to the dEs, TTDs are forming stars at present, but after 1 Gyr of passive evolution, their star formation histories would appear identical to that of dEs. As far as the stellar population is concerned, the transformation of TTDs into dEs is definitely possible. A star-forming dwarf galaxy can be stripped of at least a fraction of its gas, and its star formation rate can be reduced to that of the TTDs of the present sample. Continued gas removal may drive a galaxy to the state of a gas-depleted bona fide dE. However, we cannot exclude a scenario where a star-forming galaxy is rapidly transformed into an early type without passing through a noticeable 'transition' phase, as suggested by the relatively small fraction of observed dEs with an interstellar medium. We cannot exclude swinging back and forth between a late-type dwarf and a TTD (in the case of episodic star formation) or an early-type dwarf and a TTD (in the case of gas infall).
Profile of the horizontal wind variance near the ground in near neutral flow – K-theory and the transport of the turbulent kinetic energy

This paper deals with the characteristics of the at- mospheric turbulent flow in the vicinity of the ground, and particularly with the profile of the horizontal wind variance. The study is based on experimental measurements performed with fast cup anemometers located near the ground at 5 dif- ferent levels (from 0.25 to 4 m) and sampled at 1 Hz. The experiment was carried over two agricultural plots with var- ious tillage treatments in a fallow semiarid area (Central Aragon, Spain). The results of this study reveal that near the ground surface and under moderate wind, the horizontal wind variance logarithmically increases with height, in di- rect relationship with the friction velocity and the roughness length scale. A theoretical development has allowed us to link this behaviour to the modeling of the turbulent kinetic energy (TKE) transport through the eddy diffusivity. Thus, the study proposes a formulation of the similarity universal function of the horizontal wind variance. Besides, the for- mulation offers a new method for the determination of the friction velocity and the roughness length scale and can be used for the evaluation of the TKE transport rate.
APPLICATION OF NON-SMOOTH MODELLING TECHNIQUES TO THE DYNAMICS OF A FLEXIBLE IMPACTING BEAM

Non-smooth modelling techniques have been successfully applied to lumped mass-type structures for modelling phenomena such as vibro-impact and friction oscillators. In this paper, the application of these techniques to continuous elements using the example of a cantilever beam is considered. Employing a Galerkin reduction to form an N -degree-of-freedom modal model, a technique for modelling impact phenomena using a non-smooth dynamics approach is demonstrated. Numerical simulations computed using the non-smooth model are compared with experimentally recorded data for a flexible beam constrained to impact on one side. A method for dealing with sticking motions when numerically simulating the beam motion is presented. In addition, choosing the dimension of the model based on power spectra of experimentally recorded time series is discussed.
GenEval: A Benchmark Suite for Evaluating Generative Models

Generative models are important for several practical applications, from low level image processing tasks, to model-based planning in robotics. More generally, the study of generative models is motivated by the long-standing endeavor to model uncertainty and to discover structure by leveraging unlabeled data. Unfortunately, the lack of an ultimate task of interest has hindered progress in the field, as there is no established way to compare models and, often times, evaluation is based on mere visual inspection of samples drawn from such models. In this work, we aim at addressing this problem by introducing a new benchmark evaluation suite, dubbed GenEval. GenEval hosts a large array of distributions capturing many important properties of real datasets, yet in a controlled setting, such as lower intrinsic dimensionality, multi-modality, compositionality, independence and causal structure. Any model can be easily plugged for evaluation, provided it can generate samples. Our extensive evaluation suggests that different models have different strenghts, and that GenEval is a great tool to gain insights about how models and metrics work. We offer GenEval to the community 1 and believe that this benchmark will facilitate comparison and development of new generative models.
The resolution bias: low-resolution feedback simulations are better at destroying galaxies

We acknowledge an STFC grant. MAB is funded by a STFC research studentship. KZ is funded by the Research Council Lithuania grant no. MIP-062/2013. We thank Hossam Aly for useful discussions, and Justin Read for the use of SPHS. This research used the DiRAC Complexity system, operated by the University of Leicester IT Services, which forms part of the STFC DiRAC HPC Facility (www.dirac.ac.uk). This equipment is funded by BIS National E-Infrastructure capital grant ST/K000373/1 and STFC DiRAC Operations grant ST/K0003259/1. DiRAC is part of the UK National E-Infrastructure. Figs 3 and 4 were produced using SPLASH (Price 2007).
Pharmacometrics and systems pharmacology of immune checkpoint inhibitor nivolumab in cancer translational medicine

Nivolumab, a fully human immunoglobulin G4 (IgG4) monoclonal antibody (mAb) that targets the programmed cell death-1 (PD-1) inhibitory receptor expressed on lymphocytes and dendritic cells, has been approved for metastatic melanoma, advanced squamous non-small cell lung cancer (NSCLC) and metastatic renal cell carcinoma. In this review, pharmacology and pharmacometrics systems of this immunopharmaceutical are discussed. Mechanistic actions of T-cell biology with respect to both “priming phase” (anti-cytotoxic T-lymphocyte associated antigen 4 (anti-CTLA-4) mAb; ipilimumab) and “effector phase” (anti-PD-1 mAb; nivolumab) was discussed, respectively. Key pharmacometric variables in anticancer efficacy of nivolumab such as target engagement, metabolism, pharmacology systems and clearance are elucidated with an emphasis on current knowledge from pre-clinical as well as phase 1, 2 and 3 clinical trials information, including the data presented at the American Society of Clinical Oncology (ASCO) 2015 and European Cancer Congress 2015. Nivolumab biomarkers, safety, and synergistic combination immunotherapies are delineated. Nivolumab, administered via intravenous infusion, has an acceptable safety profile and good efficacy. Indeed, the way forward to leverage maximum benefits for the cancer patient may be to synergize anti-PD-1 blockade with complementary targets in immune checkpoint pathways or other oncogenic signal transduction pathways. The encouraging results with nivolumab lend credence to the promise of immune checkpoint blockade as a therapeutic strategy that has been come-of-age in clinical oncology. Of necessity, the burden of “financial toxicity” on cancer patients and families must be factored in considering nivolumab therapy. The problem of ligand PD-L1 being a weak biomarker in clinical practice was discussed. Appropriate patient selection methods including immunopharmacogenomics may be used to identify those patients who are most likely to benefit from anti-PD-1 therapy. Taken together, the potential success of nivolumab strengthens the case for accelerated development of immunopharmaceuticals and basic drug discovery in oncology, and potentially non-oncology indications, by stakeholders such as clinical oncologists, pharmacists and scientists in academia and the pharmaceutical industry in a concerted fashion.
OPTIMIZATION OF MICROWAVE-ASSISTED EXTRACTION OF BIOACTIVE COMPOUNDS FROM LEAVES AND STEMS OF THAI WATER SPINACH (Ipomoea aquatic var. aquatica)

In order to investigate the optimal microwave-assisted extraction condition of bioactive compounds from fresh leaf and stem of Thai water spinach (TW). Bioactive compounds were extracted with ethanol and water by microwave at 450, 600 and 850 watt for 60 seconds on ratio of 1 to 5 (sample: solvent). Phytochemical screening, total flavonoid content (TFC) and DPPH-radical scavenging activity of the extracts were determined. The highest yield was found in ethanolic extract of leaf at 600 watt (1.58%). From phytochemical screening test, all samples showed positive for alkaloids, carbohydrates, terpenes, phenols, tannins and flavonoids. The ethanolic extracts showed higher TFC than those of water extracts in all experiment conditions. The ethanolic stem extracts showed higher DPPH radical scavenging activity than those of aqueous extracts. While the aqueous leaf extracts were higher scavenging activity than those of ethanolic leaf extracts. The significantly highest flavonoid contents were found in ethanolic leaf extracted at 850 watt of power (349.69 mg QE/g dw), whereas the highest antioxidant activity was occurred in ethanolic stem extract at highest power (54.49 mg TEAC/g dw) (p<0.05, ANOVA). In conclusion, the optimal condition for extracting active compounds from TW by using microwave energy was the ethanol extracted at 850 watt for 60 seconds. This finding suggested that this plant can be used as the alternative source of active ingredient in food and cosmetics industry.
Developing the Research Basis for Controlling Bias in Hiring

Discrimination based on race, ethnicity, national origin, gender, age, disability, gender orientation, and other characteristics continues to distort employers’ hiring decisions and thereby limit employment opportunities for historically excluded groups. Research in psychology, sociology, economics, and management provides insights concerning the mechanisms of bias and interventions to mitigate their effects, but important questions remain. The innovative research technique of matched pair testing offers laboratory-like controlled conditions in quasi-experiments in real-world hiring situations. We propose seven types of testingstudiestoadvanceconceptualunderstandingofhiringbiasandimprovehiring practices.
Finite Element Analysis and Topology Optimization of Lower Arm of Double Wishbone Suspensionusing RADIOSS and Optistruct

Stability, road handling and comfort of vehicle depend on optimum design of suspension system. Mostly all passenger cars and light trucks use independent suspension system because of inherent advantages over rigid suspension systems. Double wishbone system which is also called as Short Long Arm system consists of upper and lower wishbone arms. While actual running conditions forces like braking, cornering and vertical loads are taken by lower arm of suspension system, hence probability of failure of lower arm under these forces is more . Also this component is subjected to road irregularities, hence its dynamic behavior need to be understand. This paper deals with calculating the forces acting on lower wishbone arm while vehicle subjected to critical loading conditions (Braking, Cornering and Descending though slope). Suspension geometry and suitable materials for the suspension arm has been identified. Lower arm suspension has been modeled using Pro-Engineer. Von mises stress -strain is carried out in order to find out maximum induced stress and strain, while modal analysis is done for finding out natural frequencies and mode shapes of component. These analysis were carried using Altair Hyperworks and solver used is Radioss. From the analyzed results, design parameters were compared for two different materials and best on was taken out. From result obtained it was found that current design is safe and is somewhat overdesign. So in order to save material and reduce weight of component, Topology optimization analysis is carried out in Hyperworks which yielded in optimized shape.
The autonomous city

This paper explores the recent resurgence of occupation-based practices across the globe, from the seizure of public space to the assembling of improvised protest camps. It re-examines the relationship between the figure of occupation and the affirmation of an alternative ‘right to the city’. The paper develops a critical understanding of occupation as a political process that prefigures and materializes the social order which it seeks to enact. The paper highlights the constituent role of occupation as an autonomous form of urban dwelling, as a radical politics of infrastructure and as a set of relations that produce common spaces for political action.
Task Identity and Job Autonomy as Correlates of Burnout among Nurses in Jos , Nigeria

This study examined the relationships between task identity, job autonomy and burnout of nurses in Jos, Nigeria. 79 nurses selected from three healt h ins itutions in Jos responded to Job Diagnostic Survey and Maslach Burnout Inventory. Three hypothe ses were tested using Pearson Product Moment Correlation Statistics. Findings showed that task identity had negative significant correlation with nurses experience of burnout (r(77) = -0.59, p < . 0 1)and job autonomy had a negative significant correlation with nurses experience of burnout(r(77) =-0.46,p < . 01). Discussions were made in light of extant literature. Implications of these findings w ere drawn and recommendations made for further studies.
New Alkylresorcinol Metabolites . Identification , Quantification and Evaluation as Dietary Biomarkers

Alkylresorcinols (AR) are amphiphilic phenolic lipids that are extensively metabolized in the liver and form metabolites that can be detected in plasma and urine. Two AR metabolites, 3,5-dihydroxybenzoic acid (DHBA) and 3-(3,5-dihydroxyphenyl)propanoic acid (DHPPA), have been evaluated as urinary biomarkers of whole grain wheat and rye intake. AR metabolite concentrations are currently measured by chromatographic techniques but for samples from large epidemiological studies, immunoassay techniques are preferred due to rapid and cheap analysis. The aim of this thesis was to develop high-throughput analytical methods for the analysis of alkylresorcinol metabolites and to evaluate recently discovered putative metabolites 3,5-dihydroxycinnamic acid (DHCA), 5-(3,5-dihydroxyphenyl) pentanoic acid (DHPPTA), 3,5-dihydroxycinnamic acid amide (DHCA-amide) and 2-(3,5dihydroxybenzamido) acetic acid (DHBA-glycine) as biomarkers of whole grain wheat and rye intake. Polyclonal antibodies against DHBA and DHPPA were produced and characterized in terms of cross-reactivity, assay sensitivity, precision and accuracy. A developed ELISA method was used for analysis of urine samples and results were compared with GC-MS. A lack of agreement was found. Several putative AR metabolites were identified by LC-MS/MS, including DHPPTA, DHCA, DHBA-glycine and DHCAamide. These compounds showed high cross reactivity in ELISA and likely explains the lack of agreement between the two methods. The medium-term reproducibility and relative validity of DHCA, DHPPTA and DHBA-glycine were found to be moderate to excellent in 24h urine collections. Moreover, the reproducibility was good for these metabolites also in spot-urine samples. Age and sex were found to be important determinants besides whole grain intake. The results suggest that determination of AR metabolites in 24h urine and single or duplicate spot urine samples appear to be suitable medium to long-term biomarkers of whole grain wheat and rye intake. These findings need to be confirmed in other populations before using these biomarkers in epidemiological studies.
Solar signals in CMIP‐5 simulations: the stratospheric pathway

The 11 year solar‐cycle component of climate variability is assessed in historical simulations of models taken from the Coupled Model Intercomparison Project, phase 5 (CMIP‐5). Multiple linear regression is applied to estimate the zonal temperature, wind and annular mode responses to a typical solar cycle, with a focus on both the stratosphere and the stratospheric influence on the surface over the period ∼1850–2005. The analysis is performed on all CMIP‐5 models but focuses on the 13 CMIP‐5 models that resolve the stratosphere (high‐top models) and compares the simulated solar cycle signature with reanalysis data. The 11 year solar cycle component of climate variability is found to be weaker in terms of magnitude and latitudinal gradient around the stratopause in the models than in the reanalysis. The peak in temperature in the lower equatorial stratosphere (∼70 hPa) reported in some studies is found in the models to depend on the length of the analysis period, with the last 30 years yielding the strongest response.
seasonal distribution and circadian activity in the troglophile long-footed robber frog, eleutherodactylus longipes (anura: brachycephalidae) at los riscos cave, queretaro, mexico: field and laboratory studies

Los Riscos Cave belongs to the El Abra limestone and its geographical location is in the Sierra Gorda in the State of Querétaro, Mexico. The cave has a high faunal diversity that includes arthropods and some vertebrates, such as vampire bats and anurans, and includes the robber frog Eleutherodactylus longipes (Baird, 1859). The abundance of the robber frog changes non-randomly between dry and rainy seasons and is related to the search for humid conditions inside the cave. In addition, the robber frog was located in areas where some scattered light may influence its dispersion inside the cave; and therefore, its activity. Frogs displayed spontaneous circadian rhythms of locomotor activity from the first days of the experimental observation in constant darkness. The average period of circadian rhythms was 24.85 6 0.93 h indicating, in isolated conditions, a diurnal activity. When exposed to artificial light-dark cycles, the animals lacked daily activity rhythms, and ultradian activity was observed. The preference for high humidity and low illumination in the cave and a partial endogenous circadian rhythmicity confirm the troglophilic affinity of the robber frog to cave environments.
WELFARE-MAXIMIZING OPERATIONAL MONETARY AND TAX POLICY RULES

This paper computes welfare-maximizing monetary and tax policy feedback rules in a calibrated dynamic general equilibrium model with sticky prices. The government makes exogenous final good purchases, levies a proportional income tax, and issues nominal one-period bonds. A quadratic approximation method is used to solve the model and to compute household welfare. Optimized policy has a strong anti-inflation stance and implies persistent fluctuations of the tax rate and of public debt. Very simple optimized policy rules, under which the interest rate just responds to inflation and the tax rate just responds to public debt, yield a welfare level very close to that generated by richer rules.