Miracle-dz/UniFAR-FTUs huggingface dataset:
Seizure Recurrence After A First Febrile Seizure: A Multivariate Approach

The results are presented of a follow‐up study of 155 Dutch children after the first febrile seizure. Of these initially untreated children 37 per cent had had at least one, 30 per cent at least two and 17 per cent at least three subsequent seizures. The vulnerable period for recurrent seizures after the first febrile seizure was between 12 and 24 months, whereafter the risk was four to five times lower; after any seizure the risk was highest within the first six months, declining steadily after six months without seizures. A first‐degree family history of any type of seizure predicted multiple recurrences; an age of at least 30 months and a temperature of 40d̀C at initial seizure were associated with reduced risk. Factors in combination influenced the risk of recurrent seizures, sometimes in opposite ways.
Aging Fibroblasts Present Reduced Epidermal Growth Factor (EGF) Responsiveness Due to Preferential Loss of EGF Receptors*

Wound healing is compromised in aging adults in part due to decreased responsiveness of fibroblasts to extracellular signals. However, the cellular mechanisms underlying this phenomenon are not known. Aged dermal fibroblasts with reduced remaining replicative capacities demonstrated decreased epidermal growth factor (EGF)-induced cell migrative and cell proliferative capacities, as reported previously. Thus, as cells approach senescence, programmedin vivo or in vitro, EGF responsiveness is preferentially lost. To define the rate-limiting signaling event, we found that the activity of two different EGF receptor (EGFR)-signaling pathways to cell migration (phospholipase-C γ) and/or mitogenesis (extracellular signal/regulated-mitogen-activated kinases) were decreased in near senescent cells despite unchanged levels of effector molecules. Aged cells presented decreased levels of EGFR, although insulin receptor and transferrin receptor levels were relatively unchanged. EGFR mRNA levels and production of new transcripts decreased during aging, suggesting that this preferential loss of EGFR was due to diminished production, which more than counteracts the reduced ligand-induced receptor loss. Since these data suggested that the decrement in EGF was rate-limiting, higher levels of EGFR were established in near senescent cells by electroporation of EGFR cDNA. These cells presented higher levels of EGFR and recovered their EGF-induced migration and proliferation responsiveness. Thus, the defect in EGF responsiveness of aged dermal fibroblasts is secondary to reduced EGFR message transcription. Our experimental model suggests that EGFR gene delivery might be an effective future therapy for compromised wound healing.
Efficacy of Telavancin in the Treatment of Experimental Endocarditis Due to Glycopeptide-Intermediate Staphylococcus aureus

ABSTRACT The efficacy of telavancin, a novel lipoglycopeptide, was evaluated in experimental endocarditis in rabbits using two clinical isolates of glycopeptide-intermediate Staphylococcus aureus: ATCC 700788 and HIP 5836. Infected rabbits were treated for 2 days with telavancin (10 mg/kg of body weight once daily intravenously) or vancomycin (1 g twice daily intravenously), administered with a computer-controlled infusion pump system simulating human serum kinetics. Vegetations were harvested at 16 h postinoculation in the control group and at the end of treatment in the drug-treated group. For ATCC 700788, MICs and minimal bactericidal concentrations (MBCs), respectively, were 1 mg/liter and 4 mg/liter for telavancin and 8 mg/liter and 128 mg/liter for vancomycin. For HIP 5836, MICs and MBCs, respectively, were 4 mg/liter and 8 mg/liter for telavancin and 8 mg/liter and 128 mg/liter for vancomycin. Peak and trough levels were 90 μg/ml and 6 μg/ml, respectively, for telavancin and 46 μg/ml and 6 μg/ml, respectively, for vancomycin. In glycopeptide-intermediate S. aureus ATCC 700788, telavancin sterilized 6 of 16 vegetations (37%), whereas vancomycin sterilized 4 of 20 (20%) (P = 0.29) compared with 0 of 17 in the control group. In HIP 5836 experiments, telavancin and vancomycin sterilized 5 of 16 (31%) and 1 of 15 (7%) vegetations (P = 0.17), respectively, compared with none in the control group. Telavancin reduced vegetation titers by 2.0 and 2.3 logs greater than vancomycin for the ATCC 700788 (4.6 [2.0 to 5.8] versus 6.6 [2.0 to 6.9] log CFU/g vegetation; P = 0.05) and HIP 5836 (4.4 [2.0 to 7.4] versus 6.7 [4.5 to 8.7] log CFU/g vegetation; P = 0.09) strains, respectively; these differences did not reach statistical significance. All isolates from vegetations remained susceptible to telavancin after therapy. The results suggest that telavancin may be an effective treatment for endocarditis caused by glycopeptide-intermediate S. aureus.
Performance and soundness of european banking systems

Le systeme financier joue un role crucial dans la societe moderne, devenant indispensable dans le developpement economique d’une nation. Un systeme financier optimal et un secteur bancaire performant sont consideres comme les conditions les plus importantes pour un developpement economique durable. Temoignant de l’importance du secteur bancaire, en particulier au cours du dernier siecle, cette these discute les plus important indicateurs, designes methodologiques et determinants de la performance et solidite des secteurs bancaires. La these explore en detail l’impact des facteurs specifique a la banque, a l’industrie et ceux macroeconomique sur l’evolution de la performance et solidite bancaires europeennes pendant la crise financiere internationale. En outre, la these souligne les efforts importants deployes par les decideurs politiques pendant les dernieres annees pour efficacement stimuler les secteurs economiques et pour assurer un bon fonctionnement des systemes financiers.
A pilot study combining Go4Life® materials with an interactive voice response system to promote physical activity in older women

ABSTRACT Telephone-based interactive voice response (IVR) systems could be an effective tool for promotion of physical activity among older women. To test IVR feasibility, we enrolled 30 older women in a 10-week physical activity intervention designed around National Institute on Aging (NIA) Go4Life® educational materials with IVR coaching. Participants (mean age = 76 years) significantly increased physical activity by a mean 79 ± 116 (SD) minutes/week (p < .001). Participants reported that the Go4Life® materials, pedometer, and IVR coaching (70% reported easy technology) were useful tools for change. This pilot study demonstrates IVR acceptability as an evidence-based physical activity program for older women.
Oral white sponge naevus: response to antibiotic therapy

White sponge naevus is a rare benign inherited disorder of the mucous membranes, principally the oral mucosa. Although the condition is painless, patients are often symptomatic, complaining of an altered texture of the mucosa or that the lesions are unaesthetic. No standard treatment for the condition exists although numerous treatments have been tried. We now report on six patients who were prescribed systemic antibiotic therapy; three were adult men aged 24 years, 32 years, and 52 years, one an 11‐year‐old woman, one a 6‐year‐old woman (daughter of the 32‐year‐old man) and an 18‐month‐old boy (son of the 24‐year‐old man). Four responded as judged by clinical examination, although not the 6‐year‐old female or the 18‐month‐old male; the discontinuation of therapy then resulted in clinical recurrence in those who had responded, but long‐term low dose treatment maintained the remission.
Corpus luteum blood flow in abnormal early pregnancy.

Thirty‐eight consecutive patients with the diagnosis of abnormal early singleton pregnancy were studied with transvaginal color velocity imaging and pulsed Doppler ultrasonography to assess corpus luteum blood flow. Mean gestational age was 8.5 weeks (range, 6 to 12 weeks). Patients' mean age was 30.9 years (range, 24 to 43 years). There were 19 (50%) threatened abortions, 13 (34.2%) missed abortions, and six (15.8%) anembryonic pregnancies. Blood flow impedance in the corpus luteum was estimated by calculating the resistive index. The results of this study group were compared with those obtained in a series of 85 normal singleton early pregnancies used as controls. Overall, detection of corpus luteum blood flow was 78.9% in study group and 76.4% in control group (P = 0.51). Mean resistive index +/‐ standard deviation in the control group was 0.50 +/‐ 0.10; the corresponding values in threatened abortion, anembryonic pregnancy, and missed abortion were 0.52 +/‐ 0.10, 0.42 +/‐ 0.06, and 0.57 +/‐ 0.05, respectively. No statistical. differences in mean resistive index were found among threatened abortion and anembryonic pregnancy with respect to control group. A higher mean resistive index was observed in missed abortion than in control group (P < 0.01). In conclusion, our data show that luteal vascularization might be decreased in missed abortion but not in threatened abortion and anembryonic pregnancy.
Identifying paths to audience success of media products: the media decision-makers’ perspective

ABSTRACT Research on media success factors is a fragmented field. Definitions, measures, and methods vary, and findings are often inconsistent. In an attempt to fill this perceived research gap, we distilled generic success factors of media products from the literature. Guided by theory and empirical findings, these factors were aggregated to complex concepts, building blocks of success that we further investigated in an exploratory qualitative study. We found that the building blocks are applicable to all types of media, independent of seriality and content types of media products. Subsequently the research question of this article is: Which building blocks of success are most important for media products? To answer this question, we conducted an online survey of 255 media professionals in print, audio-visual, and online media in Austria, Germany and Switzerland. To analyze our data, we deployed qualitative comparative analysis, a method based on set theory that is suitable to investigate complex causality. We conclude that four building blocks are necessary for success: “good” distribution, environmental orientation, form/design, and human resources are preconditions for achieving success in terms of audience market share. In addition, three patterns emerge in the sufficient paths (combinations of building blocks) to success. Which route to success a media product shows can be related to the width of its topical scope and the corresponding projected audience size.
Fingerprint, Monitoring and Work Discipline of Indonesian Public Servants: Evidence from Kepulauan Riau

Recently, there are many public organizations in Indonesia use fingerprint to controll the attendance of the employee. However, the effectiveness of the implementation of this system has never been evaluated. This research aims at examining the influence of the using fingerprint and monitoring on work discipline of the employees in vertical organizations below the Ministry of Education and Culture of Republic of Indonesia in Kepulauan Riau. 44 public employees from the Board of Cultural Preservation and Language Office have been participated in this study. Using multiple linear regression, this study reveals that the using of fingerprint and monitoring have significant influence on work discipline simultanoeusly. Monitoring has positive influence on work discipline. Meanwhile, implementation of fingerprint has not influence on work discipline. Through this study, authors deny the perception of many policy makers in Indonesia and prior scholars that fingerprint can increase the discipline of public servants.
Cdk2 and Cdk4 Regulate the Centrosome Cycle and Are Critical Mediators of Centrosome Amplification in p53-Null Cells

ABSTRACT The two mitotic centrosomes direct spindle bipolarity to maintain euploidy. Centrosome amplification—the acquisition of ≥3 centrosomes—generates multipolar mitoses, aneuploidy, and chromosome instability to promote cancer biogenesis. While much evidence suggests that Cdk2 is the major conductor of the centrosome cycle and that it mediates centrosome amplification induced by various altered tumor suppressors, the role played by Cdk4 in a normal or deregulated centrosome cycle is unknown. Using a gene knockout approach, we report that Cdk2 and Cdk4 are critical to the centrosome cycle, since centrosome separation and duplication are premature in Cdk2−/− mouse embryonic fibroblasts (MEFs) and are compromised in Cdk4−/− MEFs. Additionally, ablation of Cdk4 or Cdk2 abrogates centrosome amplification and chromosome instability in p53-null MEFs. Absence of Cdk2 or Cdk4 prevents centrosome amplification by abrogating excessive centriole duplication. Furthermore, hyperactive Cdk2 and Cdk4 deregulate the licensing of the centrosome duplication cycle in p53-null cells by hyperphosphorylating nucleophosmin (NPM) at Thr199, as evidenced by observations that ablation of Cdk2, Cdk4, or both Cdk2 and Cdk4 abrogates that excessive phosphorylation. Since a mutant form of NPM lacking the G1 Cdk phosphorylation site (NPMT199A) prevents centrosome amplification to the same extent as ablation of Cdk2 or Cdk4, we conclude that the Cdk2/Cdk4/NPM pathway is a major guardian of centrosome dysfunction and genomic integrity.
PENGARUH CORPORATE SOCIAL RESPONSIBILITY (CSR) TERHADAP NILAI PERUSAHAAN

Penelitian ini berpangkal pada masalah kurangnya perhatian sejumlah perusahaan terhadap CSR. Mereka beranggapan CSR hanya akan membebani kinerja keuangan perusahaan yang berakibat pada nilai perusahaan. Penelitian ini bertujuan untuk mengetahui: Pengaruh CSR terhadap nilai perusahaan, pengaruh CSR terhadap nilai perusahaan, dengan kepemilikan institusional, kepemilikan manajemen, dan ukuran perusahaan sebagai variabel moderating. Metode penelitian yang digunakan adalah metode penelitian asosiatif kausal. Populasi dalam penelitian adalah 42 perusahaan pemenang ISRA, sedangkan sampel penelitian merupakan perusahaan yang memenuhi kelengkapan data penelitian sebanyak 31 perusahaan. Teknik analisis yang digunakan adalah analisis regresi sederhana, analisis regresi uji nilai selisih mutlak, dan analisis regresi berganda. Hasil penelitian ini menunjukkan bahwa CSR, CSR parameter environment, community, employment berbengaruh positif dan tidak signifikan terhadap nilai perusahaan. Kepemilikan institusional, kepemilikan manajemen, dan ukuran perusahaan sebagai variabel moderating tidak mampu memoderasi pengaruh CSR terhadap nilai perusahaan. Kata kunci: CSR, nilai perusahaan, environment, community, environment, institusional, manajemen, ukuran perusahaan
Intention Model of Waste Management Education Concept Based on Green Campus in Brawijaya University

This research was aimed to analyze the behaviors of Brawijaya University’s stakeholders through the intention in managing waste. Considering that campus is a place of education, the analysis of the intention associated with the educational theory in cognitive, affective and psychomotor domains. Thus, this research implementation was supported by intention model. The objects of this research were the stakeholders of Brawijaya University consisting of students, lecturers, and staffs. This research was done using survey method with a total of 120 respondents. The analysis was conducted using a path analysis method with trimming. Given that the number of variables used was quite a lot, the data were first analyzed using a factor analysis method and then followed with a path analysis method. The results of the path analysis on Model 1 showed that the significant variables to the intention of managing waste were cognitive and behavioral control variables. The indicators of cognitive variable as knowing the types of waste and the economic benefits of waste. As for Model 2, the intention of managing waste significantly influenced the realization of the green campus varibles. The indicators of managing waste intention as intention to help manage waste in Brawijaya University, and then the indicators of green campus varible as the emerge of wise thoughts. As the suggestion, rules or policies on waste management are highly required to be established in Brawijaya University so that the stakeholders are willing to manage and process waste. Keywords: Affective and psychomotor domains, Brawijaya University’s stakeholders, Cognitive, Green campus, Waste management intention model
Influence of variations in albumin or total-protein concentration on serum fructosamine concentration.

To the Editor: Johnson et a! (1) developed a new method for determining glycosylated serum proteins, the fructosamine test. Serum fructosamine concentration, as an indication of glycosylation of serum proteins, reflects the time-integrated glucose concentration over the previous two to four weeks and can be used for the follow-up of diabetes mellitus. Recently, several papers have been published on the use of values of serum fructosamine for diabetes control. The diagnostic value of this test for gestational diabetes or diabetes mellitus is still under investigation. However, to make the test suitable for diagnostic purposes and not only for follow-up, a high sensitivity is required. Baker et al. (2) stated that serum fructosamine concentration is independent of albumin or total protein concentration, if the albumin concentration in serum exceeds 30 g/L. Uoyd and Marples (3) reported that albumin influences the measurement, but for concentrations >35 g/L this was not a serious problem. Urn and Staley (4) observed no differences in serum fructosamune concentrations between hospitalized nondiabetic patients and ambulatory nondiabetic subjects. We measured serum fructosamine, serum albumin, total protein and blood glucose concentrations during fasting in 103 hospitalized and non-hospitalized, non-diabetic patients. Because serum albumin and total protein concentrations generally decrease during hospitalization and bed rest (by 5 to 10 g/L) it was possible to examine the influence of changing serum albumin and total protein concentrations on serum fructosamine concentrations. Because albumin is by far the most predominant glucose-binding protein in serum, we concentrated our studyalso on the relation between fructosamine and albumin concentrations. Both hospitalized and non-hospitalized patients had fasting glucose values <5.5 mmol/L and no history of diabetes mellitus. Moreover, the nonhospitalized patients had normal results for an oral glucose tolerance test. We observed a highly significant correlation (5) between the albumin or protein concentration in serum vs sorum fructosamine concentration, as shown in the following tabulation:
Network effects at retail payments market: evidence from Russian merchants

This research examines the role of network externalities in card acceptance by merchants on the retail payments market in Russia. The work empirically tests the effects of both direct and indirect network externalities for the merchants? card acceptance probability based on the representative survey of 800 traditional (offline) merchants from all Russian regions. The main finding of this study is that the probability of cashless payments acceptance by merchants increases with the presence of direct and indirect or both types of network externalities, controlling for a large set of control variables, including merchants? characteristics and location-specific differences between the retailers. The results are robust to the changes in measures of network externalities and inclusion of shadow economy controls. The findings are significant both statistically and economically.
The influence of alpha-lipoic acid on the toxicity of cadmium.

Alpha-lipoic acid (alpha-LA) is an important antioxidant drug with chelating properties. In experiments performed in male mice (CD-1, Charles River) the effects of cadmium on lipid peroxidation (LP), GSH level, the activity of catalase and glutathione peroxidase (GSH-Px) in liver homogenates were studied. Mice were injected with CdCl2 x 2.5 H2O at a dose of 40 micromol x kg(-1) s.c. Alpha-LA was administered simultaneously i.p. at the dose corresponding to alpha-LA-to-Cd molar ratio of 5:1. The experiments were completed at 24 h. Cadmium increased LP to 200.7% of controls. This effect was prevented by alpha-LA treatment (p < or = 0.05). GSH level was decreased to 81.7% of controls and it was not affected by alpha-LA. GSH-Px activity diminished by Cd administration was corrected by alpha-LA (p < 0.001). Catalase activity decreased by Cd remained unaffected. The administration of alpha-LA alone enhanced LP and the activity of catalase. As estimated by AAS, Cd content in the liver, the kidneys, the brain and the testes remained unaffected by alpha-LA treatment. In the acute toxicity experiment, the mortality associated with cadmium was decreased by alpha-LA administration. The results suggest that the toxicity of Cd was decreased mainly by the antioxidant activity of alpha-LA rather than by cadmium removal from tissues.
Influence of Father–Infant Relationship on Infant Development: A Father-Involvement Intervention in Vietnam

We examined the extent to which fathers can be taught and encouraged to develop positive relationships with their children, especially in infancy, and the effects of this fathering intervention on infant development. A multifaceted relationally focused intervention was used to assist fathers in Vietnam to engage in responsive direct and indirect involvement with their infants and work together with the mother as part of a parenting team. Fathers and mothers from 13 communes in a rural and semiurban district were recruited to the intervention group. Intervention fathers received group and individual counseling before and after birth, an interactive print resource, community messages about fathering, and the opportunity to participate in a Fathers Club. Couples from 12 comparable communes in a noncontiguous district were recruited to the control group. Fathers and mothers completed questionnaires at the prebirth recruitment and at 1-, 4-, and 9-months postbirth. Intervention fathers demonstrated greater increase in knowledge and attitudes regarding father–infant relationships. Both fathers and mothers reported that fathers engaged in more affection, care-taking, and play in the early months of their infants’ lives and fathers felt more attached to their infants right from birth. A developmental assessment at 9 months showed that intervention infants demonstrated higher levels of motor, language, and personal/social development. This study demonstrated that fathers can be taught to interact more sensitively, responsively, and effectively with their newborn infants. Their increased interaction and emotional attachment appears to lay the foundation for enhanced infant development.