Miracle-dz/UniFAR-FTUs huggingface dataset:
Did the Zipingpu Reservoir trigger the 2008 Wenchuan earthquake?

The devastating May 2008 Wenchuan earthquake (Mw 7.9) resulted from thrust of the Tibet Plateau on the Longmen Shan fault zone, a consequence of the Indo‐Asian continental collision. Many have speculated on the role played by the Zipingpu Reservoir, impounded in 2005 near the epicenter, in triggering the earthquake. This study evaluates the stress changes in response to the impoundment of the Zipingpu Reservoir and assesses their impact on the Wenchuan earthquake. We show that the impoundment could have changed the Coulomb stress by −0.01 to 0.05 MPa at locations and depth consistent with reported hypocenter positions. This level of stress change has been shown to be significant in triggering earthquakes on critically stressed faults. Because the loading rate on the Longmen Shan fault is <0.005 MPa/yr, we thus suggest that the Zipingpu Reservoir potentially hastened the occurrence of the Wenchuan earthquake by tens to hundreds of years.
Intracellular and extracellular levels of cyclic AMP during the cell cycle of Saccharomyces cerevisiae

Using the techniques of centrifugal elutriation it was demonstrated that during the cell division cycle of the budding yeast Saccharomyces cerevisiae there are stage‐specific fluctuations in the intracellular concentration of adenosine 3′,5′‐cyclic monophosphate (cAMP). Results shown here indicate that the intracellular concentration of cAMP is at its highest during the division cycle, and its lowest immediately prior to and just after cell sepraration. Results also show the extrusion of extracellular cAMP into the medium by Saccharomyces cerevisiae, extracellular cAMP levels being ten to one hundred times higher than intracellular levels. During the cell of Saccharomyces cerevisiae the extracellular level of cAMP does not fluctuate.
Glucuronidation of bioflavonoids by human UGT1A10: structure–function relationships

The extrahepatic human UDP glucuronosyltransferase 1A10 is found throughout the gastrointestinal tract and is thought to participate in the removal of orally ingested lipophilic chemicals. However, its substrate specificity towards these chemicals has not been fully characterized. The structurally diverse bioflavonoids are present in considerable amounts in fruits, vegetables and plant–derived beverages and have been shown to have many biological functions, including antioxidant properties. This study proposes features of the bioflavonoid structure necessary to confer it as a substrate of UGT1A10. The preferred substrates of UGT1A10 contain the hydroxyl group to be glucuronidated at C6 or C7, but not C5 of the A–ring or on C4′ of the B–ring. Up to two additional hydroxyl groups on the A–ring enhance activity, whereas the presence of other groups, notably sugar groups, decreases activity. The high glucuronidation efficiency towards many bioflavonoids observed suggests that the contribution of UGT1A10 in the metabolism of these dietary compounds in the gastrointestinal tract may be significant.
Development of functional connections between thalamic fibres and the visual cortex of the wallaby revealed by current source density analysis in Vivo

Functional development of thalamic input to the cortex in anaesthetised wallaby pouch young between postnatal day 25 (P25) and P153 has been studied by electrical stimulation of the optic nerve, current source density (CSD) analysis, and histologic identification of recording sites. Conduction in the optic nerve was recorded prior to P39, by which time responses from the superior colliculus appeared. No evoked potential of cortical origin was recorded until P46, even though thalamic fibres grew into the cortical plate from P15. The first cortical synaptic responses were recorded at the margin of the subplate and the developing cortical plate, where cells that later comprise the adult layer 6 settle. At about P66, an additional short‐latency, superficial response appeared, coinciding with the formation of layer 4. The deep response was retained in layer 6. Evoked activity in the presumed layer 4 was found progressively deeper in the cortex over the next few weeks, which would be expected from the addition of layer 3 above it. By P113, a new sink was added superficial in the cortex. Thalamocortical connections follow the same deep‐to‐superficial order in development as the cellular layers of the cortex. J. Comp. Neurol. 418:441–456, 2000. © 2000 Wiley‐Liss, Inc.
Analysis of 2013 European LeukaemiaNet (ELN) responses in chronic phase CML across four frontline TKI modalities and impact on clinical outcomes

This study assessed the relevance of 2013 European LeukaemiaNet (ELN) response categories on patients treated with common frontline tyrosine kinase inhibitors (TKI) in chronic myeloid leukaemia in chronic phase (CML‐CP). Four hundred and eighty‐seven patients treated with imatinib (400 mg; IM 400, n = 70; 800 mg; IM800, n = 201), dasatinib (n = 107) or nilotinib (n = 109) were analysed. Intention to treat (ITT) analysis indicated that the proportion of patients falling into optimal, warning and failure ELN categories were 89%, 6%, 6% at 3 months, 78%, 17% and 6% at 6 months, and 75%, 13% and 13% at 12 months, respectively. Rates of optimal response at 3 months were 75% for IM400, 90% for IM800, 89% for dasatinib and 97% for nilotinib; 41%, 80%, 86% and 89% at 6 months; and 47%, 77%, 76% and 87% at 12 months, respectively. Patients achieving optimal response had longer eventfree (EFS), failurefree (FFS), transformationfree (TFS) and overall survival (OS) compared to warning and failure responses at all‐time points. Treatment with imatinib 800, dasatinib or nilotinib predicted for achieving an optimal response. Optimal response predicted for significantly longer EFS, FFS, TFS and OS at 3, 6 and 12 months, irrespective of the TKI modality used. ELN response categories reliably predicted outcomes in CML patients receiving commonly used TKIs.
Auditory profiling and hearing-aid satisfaction in hearing-aid candidates.

INTRODUCTION Hearing-impaired (HI) listeners often complain about difficulties communicating in the presence of background noise, although audibility may be restored by a hearing-aid (HA). The audiogram typically forms the basis for HA fitting, i.e. people with similar audiograms are given the same prescription by default. This study aimed at identifying clinically relevant tests that may serve as an informative addition to the audiogram and which may relate more directly to HA satisfaction than the audiogram does. METHODS A total of 29 HI and 26 normal-hearing listeners performed tests of spectral and temporal resolution, binaural hearing, speech intelligibility in stationary and fluctuating noise and a working-memory test. Six weeks after HA fitting, the HI listeners answered a questionnaire evaluating HA treatment. RESULTS No other measures than masking release between fluctuating and stationary noise correlated significantly with audibility. The HI listeners who obtained the least advantage from fluctuations in background noise in terms of speech intelligibility experienced greater HA satisfaction. CONCLUSION HI listeners have difficulties in different hearing domains that are not predictable from their audiogram. Measures of temporal resolution or speech perception in both stationary and fluctuating noise could be relevant measures to consider in an extended auditory profile. FUNDING The study was supported by Grosserer L.F. Foghts Fond. TRIAL REGISTRATION The protocol was approved by the Science Ethics Committee of the Capital Region of Denmark (reference H-3-2013-004).
Correction: Lysyl oxidases regulate fibrillar collagen remodelling in idiopathic pulmonary fibrosis (doi: 10.1242/dmm.030114)

An error was published in Dis. Model. Mech. (2017). 10 , [1301-1312][1] (doi: [10.1242/dmm.030114][2]). A reference was incorrectly cited in the Results section (subsection ‘Inhibition of LO activity reduced TGF-β-induced collagen remodelling in collagen I hydrogels’). The corrected sentence
The prevalence of dental impacts on daily performances in older people in Northern Thailand.

OBJECTIVE To assess the prevalence of oral related impacts on the quality of daily life in older Thais. DESIGN A cross-sectional study on a non-random sample. SETTING Metropolitan area of Chiang Mai, Thailand Subjects: 707 older individuals living independently, aged 60 to 74 years, 549 were dentate, 158 were edentate. METHODS Clinical examination and questionnaire for the Oral Impacts on Daily Performances (OIDP) index and on dental behaviours. RESULTS About one half of the older people interviewed (52.8%) had at least one OIDP oral impact. The most common performance affected was eating (47.2%). The two main symptoms that caused oral impacts in the total sample were functional limitation and pain. The majority of older people had low OIDP scores below 8.0 (76.4%). Almost one in 10 had OIDP scores above 16.0. Individuals with a high income were more likely to have lower OIDP score (p<0.001). Subjects who had attended a dentist were more likely to have no oral impacts (p=0.02). There was a significant difference between OIDP scores related to some clinical variables; dental status (p=0.002), having mobile teeth (p=0.005), periodontal attachment loss (p<0.001), missing anterior and posterior teeth (p<0.001). CONCLUSIONS Oral impacts that affected quality of life of older people were relatively common but not severe. The impacts were related to some social and clinical variables.
Nutritional screening, assessment and implementation strategies for adults in an Australian acute tertiary hospital: a best practice implementation report

Objective: The project aimed to improve the effectiveness of nutritional screening and assessment practices through clinical audits and the implementation of evidence-based practice recommendations. Introduction: In the absence of optimal nutrition, health may decline and potentially manifest as adverse health outcomes. In a hospitalized person, poor nutrition may adversely impact on the person's outcome. If the nutritional status can be ascertained, nutritional needs can be addressed and potential risks minimized. The overall purpose of this project was to review and monitor staff compliance with nutritional screening and assessment best practice recommendations ensuring there is timely, relevant and structured nutritional therapeutic practices that support safe, compassionate and person-centered care in adults in a tertiary hospital in South Western Sydney, Australia, in the acute care setting. Methods: A baseline retrospective chart audit was conducted and measured against 10 best practice criteria in relation to nutritional screening and assessment practices. This was followed by a facilitated multidisciplinary focus group to identify targeted strategies, implementation of targeted strategies, and a post strategy implementation chart audit. The project utilized the Joanna Briggs Institute Practical Application of Clinical Evidence System (JBI PACES) and Getting Research into Practice (GRIP) tool, including evidence from other available supporting literature, for promoting change in healthcare practice. Results: The baseline audit revealed deficits between current practice and best practice across the 10 criteria. Barriers for implementation of nutritional screening and assessment best practice criteria were identified by the focus group and an education strategy was implemented. There were improved outcomes across all best practice criteria in the follow-up audit. Conclusions: The baseline audit revealed gaps between current practice and best practice. Through the implementation of a targeted education program and resource package, outcomes improved in the follow up audit. The findings indicated that engagement from multidisciplinary team members and consumers was effective in developing tailored education that improved knowledge of best practice. This was demonstrated by an increase in the percentage of compliance across the 10 criteria, although leaving room for more improvement. A policy has been developed for implementation and future audits are planned to measure whether improved practices have been sustained.
Receptors, gephyrin and gephyrin‐associated proteins: novel insights into the assembly of inhibitory postsynaptic membrane specializations

The synaptic localization of ion channel receptors is essential for efficient synaptic trans‐mission and the precise regulation of diverse neuronal functions, such as signal integration and synaptic plasticity. Emerging evidence points to an important role of cytoskeleton‐associated proteins that assemble receptors and components of the subsynaptic machinery at postsynaptic membrane specializations. This article reviews interactions of inhibitory postsynaptic neurotransmitter receptors with the receptor anchoring protein gephyrin and intracellular components involved in downstream signalling and/or control of signal transduction processes. The presently available data suggest a central synaptic organizer function for gephyrin in inhibitory postsynaptic membrane assembly and stabilization.
Effect of temozolomide on central nervous system relapse in patients with advanced melanoma

Temozolomide has shown efficacy in the treatment of metastatic melanoma similar to that of dacarbazine (DTIC), the standard chemotherapy, but with the added benefit of penetration into the central nervous system (CNS). Isolated CNS relapse is increasingly a problem for patients who respond to biochemotherapy. By replacing DTIC with temozolomide in treatment regimens, the incidence of CNS relapse might be reduced. This hypothesis is difficult to test in a prospective randomized controlled trial because of the large number of patients that would be required. We have examined this question in a retrospective case control study, observing the rates of CNS relapse in advanced metastatic melanoma patients responding to DTIC- or temozolomide-based chemotherapy in three institutions. Twenty-one DTIC and 20 temozolomide responders were identified, and have been followed up for a median of 19.0 months (range 6.0–74.3 months). CNS relapse occurred in nine DTIC- and two temozolomide-treated patients, a statistically significant difference in favour of the new agent (P = 0.03). These results support the investigation of temozolomide as a replacement for DTIC in systemic treatment regimens for melanoma.
Second malignancies after treatment of Hodgkin's disease: the influence of treatment, follow-up time, and age.

PURPOSE In the period 1968 through 1988, The Norwegian Radium Hospital (NRH) treated an unselected population of 1,152 patients with Hodgkin's disease (HD) that comprised more older patients (mean age, 43 years) than most other institutions. We considered it important to evaluate these patients for development of second cancers (SCs). PATIENTS AND METHODS The Norwegian Cancer Registry identified previously untreated patients with HD treated at NRH who had developed a SC more than 1 year after diagnosis of HD. The relative risk ratio (RR) (observed/expected cases) and the cumulative risk were calculated. RESULTS Sixty-eight patients had developed a SC, including nine acute nonlymphocytic leukemias (ANLLs), eight non-Hodgkin's lymphomas (NHLs), and 51 solid tumors, including 11 lung cancers. The RR of SC and leukemia was 1.86 (95% confidence interval [CI], 1.4 to 2.4) and 24.3 (95% CI, 11.1 to 46.2), respectively. The RR of SC was highest in younger patients (< 41 years, RR = 3.8). No significant association between splenectomy and development of ANLL was found. The influence of treatment and follow-up time on the development of SC agrees with data from other large cancer institutions. CONCLUSION (1) The low RR of developing a SC in this study is probably due to the number of older patients included, who have a lower RR of developing a SC due to less aggressive treatment, shorter follow-up time, and higher incidence of cancer in the expected background population. (2) The low RR and cumulative risk of developing ANLL may be due to the limited use of extensive chemotherapy (CT) in our hospital in the earlier years.
THE EFFECTS OF DIFFUSENESS AND DEEP PERFORATING ARTERY SUPPLY ON OUTCOMES AFTER MICROSURGICAL RESECTION OF BRAIN ARTERIOVENOUS MALFORMATIONS

OBJECTIVEDiffuse arteriovenous malformations (AVM) have non-compact niduses, irregular margins, and intervening brain parenchyma. Deep perforating arteries often contribute to the ragged border of these diffuse AVMs. We hypothesized that diffuseness and deep perforator supply increase the difficulties and risks associated with microsurgical AVM resection. METHODSDiffuseness was quantified using computer-generated outlines of AVMs on angiograms, contour plots with varying image intensities, and calculations of nidus area-intensity profiles. Diffuse AVMs had nonlinear area-intensity profiles with high transition intensities ([I*] greater than 0.5). A consecutive series of 304 patients who were treated with microsurgical AVM resection over a period of 7.8 years was analyzed, along with quantification of diffuseness in a subset of 103 consecutive patients. Neurological outcomes were assessed by using the Modified Rankin Scale, and logistic regression analysis was used to identify predictors of deterioration and poor outcome at late follow-up evaluation. RESULTSDiffuse niduses were observed in 25% of patients, and 18% of patients had deep perforating artery supply. Patients with compact AVMs were more likely to have good outcomes or overall improvement (88 and 87%, respectively) than patients with diffuse AVMs (65 and 54%, respectively) (P = 0.008 and P < 0.001, respectively). Similarly, absence of deep perforator supply was associated with good outcomes or improvement in 85 and 78% of patients, respectively, compared with 63 and 64% of patients, respectively, in patients with deep perforator supply (P < 0.001 and P = 0.028, respectively). By logistic regression analysis, diffuseness and deep perforator supply were both associated with significant increases in surgical risk. CONCLUSIONDiffuseness and deep perforating artery supply are subtle features of an AVM that predict worse outcomes after microsurgical resection. Diffuseness makes surgical planes more difficult to determine and follow, whereas deep perforators are friable, poorly visualized, and located in eloquent white matter tracts. The Spetzler-Martin grading scale does not directly account for these two features; however, they should be considered carefully when making treatment recommendations to patients with AVMs.
mTOR target NDRG1 confers MGMT-dependent resistance to alkylating chemotherapy

Significance N-myc downstream regulated gene 1 (NDRG1) is a central and druggable molecular hub integrating diverse therapy-induced microenvironmental factors to promote resistance toward alkylating chemotherapy. We suggest that NDRG1-mediated chemoprotection is achieved via binding and stabilizing methyltransferases, such as O6-methylguanine-DNA methyltransferase. A hypoxic microenvironment induces resistance to alkylating agents by activating targets in the mammalian target of rapamycin (mTOR) pathway. The molecular mechanisms involved in this mTOR-mediated hypoxia-induced chemoresistance, however, are unclear. Here we identify the mTOR target N-myc downstream regulated gene 1 (NDRG1) as a key determinant of resistance toward alkylating chemotherapy, driven by hypoxia but also by therapeutic measures such as irradiation, corticosteroids, and chronic exposure to alkylating agents via distinct molecular routes involving hypoxia-inducible factor (HIF)-1alpha, p53, and the mTOR complex 2 (mTORC2)/serum glucocorticoid-induced protein kinase 1 (SGK1) pathway. Resistance toward alkylating chemotherapy but not radiotherapy was dependent on NDRG1 expression and activity. In posttreatment tumor tissue of patients with malignant gliomas, NDRG1 was induced and predictive of poor response to alkylating chemotherapy. On a molecular level, NDRG1 bound and stabilized methyltransferases, chiefly O6-methylguanine-DNA methyltransferase (MGMT), a key enzyme for resistance to alkylating agents in glioblastoma patients. In patients with glioblastoma, MGMT promoter methylation in tumor tissue was not more predictive for response to alkylating chemotherapy in patients who received concomitant corticosteroids.
Mesenchymal stem cells effectively reduce surgically induced stenosis in rat carotids

Restenosis following vascular injury remains a pressing clinical problem. Mesenchymal stem cells (MSCs) promise as a main actor of cell‐based therapeutic strategies. The possible therapeutic role of MSCs in vascular stenosis in vivo has been poorly investigated so far. We tested the effectiveness of allogenic bone marrow‐derived MSCs in reduction of stenosis in a model of rat carotid arteriotomy. MSCs were expanded in vitro retaining their proliferative and differentiation potentiality. MSCs were able to differentiate into adipocyte and osteocyte mesenchymal lineage cells, retained specific antigens CD73, CD90, and CD105, expressed smooth muscle alpha‐actin, were mainly in proliferative phase of cell cycle and showed limited senescence. WKY rats were submitted to carotid arteriotomy and to venous administration with 5 × 106 MSCs. MSCs in vivo homed in injured carotids since 3 days after arteriotomy but not in contralateral uninjured carotids. Lumen area in MSC‐treated carotids was 36% greater than in control arteries (P = 0.016) and inward remodeling was limited in MSC‐treated carotids (P = 0.030) 30 days after arteriotomy. MSC treatment affected the expression level of inflammation‐related genes, inducing a decrease of IL‐1β and Mcp‐1 and an increase of TGF‐β in injured carotids at 3 and 7 days after arteriotomy (P < 0.05). Taken together, these results indicate that allogenic MSC administration limits stenosis in injured rat carotids and plays a local immunomodulatory action. J. Cell. Physiol. 217: 789–799, 2008. © 2008 Wiley‐Liss, Inc.
U.S. East Coast Trough Indices at 500 hPa and New England Winter Climate Variability

Abstract Using monthly gridded 500-hPa data, two synoptic indices are defined to better understand the principle mechanisms controlling intraseasonal to multiannual winter climate variability in New England (NE). The “trough axis index” (TAI) is created to quantify the mean longitudinal position of the common East Coast pressure trough, and the “trough intensity index” (TII) is calculated to estimate the relative amplitude of this trough at 42.5°N. The TAI and TII are then compared with records for NE regional winter precipitation, temperature, and snowfall with the goal of understanding physical mechanisms linking NE winter climate with regional sea surface temperatures (SST), the North Atlantic Oscillation (NAO), and the Pacific–North American (PNA) teleconnection pattern. The TAI correlates most significantly with winter precipitation at inland sites, such that a western (eastern) trough axis position is associated with greater (lower) average monthly precipitation. Also, significant correlations betwe.