Miracle-dz/UniFAR-FTUs huggingface dataset:
The effect of soft X‐radiation on myofibrils

Myofibrils, the contractile organelles from striated muscles, have been examined in the X‐ray microscope to determine the effect of radiation on their function and structure. Using X‐rays of energy 350–385 eV in the water window we find that after an exposure to 7·5 × 105 photons/μm2 (calculated to give an absorbed dose of 20000 Gy) the myofibrils will no longer contract. The use of the free radical scavenging agent, DMSO, gives some protection to the fibrils. It has also been found that after this much irradiation the fibrils lose up to 20% of their mass. Further substantial mass loss occurs on subsequent irradiation. After 25 times the loss‐of‐function exposure only 30% of the mass remains. Analysis of a series of images of the same myofibril covering this range of exposures shows that the mass is preferentially lost in some areas of the structure and consequently significant structural changes occur.
Circulating levels of growth hormone, insulin‐like growth factor‐I and growth hormone binding protein in normal women of advanced reproductive age

OBJECTIVE Women experience an age‐related decline in fertility despite regular ovulatory cycles and normal production of ovarian steroids. Growth hormone and IGF‐I are both reported to decline with age, and there is evidence that both hormones promote intraovarian actions of gonadotrophins. The purpose of this study was to characterize circulating levels of GH and IGF‐I in normal, older reproductive age women with ovulatory cycles.
[Serotyping of group B streptococcus in microbiological samples at the Robert-Ballanger hospital].

From February to September 1993, we have established the serotype of group B Streptococcus (GBS) taken from diverse microbiological samples, in particular from gastric liquids. The method utilized was a technic of coagglutination (Dako Group B Streptococcus Serotyping Test, France) allowing the search for serotypes Ia, Ib, II, III, IV and V. All in all, 169 samples have been tested: 117 vaginal samples, 17 diverse samples, 26 gastric samples, 3 placentas and 7 ammmiotic liquids. Serotypes are spread as follow: III (41), II (33), Ia (26) et V (23). Usually, serotype III was the most frequently found and the most virulent, particularly in infections in neonates.
Emerging Role of P53, Bcl‐2 and Telomerase Activity in Egyptian Breast Cancer Patients

Apoptotic cell death represents an important mechanism for the precise regulation of cell numbers, and a defense mechanism against tumor cells. Both bcl‐2 and mutant p53 gene products have been involved in apoptotic pathways. On the other hand, cell proliferation capacity and tumorgenesis have been controlled by telomerase. The purpose of our study is to assess the prognostic significance of additional markers implicated in apoptosis and tumorgenesis. Fifty‐one fresh tissue samples of primary breast carcinoma and 26 tissue samples of benign breast lesions were included in this study. Expression of bcl‐2 in cell lysates and mutant p53 protein in nuclear fraction were measured by Oncogene Science EIA procedures. Telomerase activity was analyzed using the Telomerase‐PCR‐ELISA based on the TRAP (telomerase repeat amplification protocol) method. On the same specimens, steroid hormone receptors (ER and PgR) were measured in cytosol fraction using Abbott EIA assays. In addition, information regarding surgical‐pathological features of the tumor was obtained. Univariate and Multivariate analysis was done to identify variables predictive of poor prognosis. Significant expression of bcl‐2, mutant p53 proteins and relative telomerase activity were observed in malignant cases when compared to benign ones. Univariate analysis revealed significant association in the level of both mutant p53 and relative telomerase activity with tumor size and disease recurrence. Moreover, telomerase activity was significantly expressed in late stages than early ones. Multivariate analysis revealed that bcl‐2, mutant p53, telomerase activity, PgR and age were independent prognostic factors. Among a panel of molecular genetic factors investigated, mutant p53 and relative telomerase activity were strongly associated with disease recurrence; hence they exert a significant prognostic role in breast cancer. IUBMB Life, 56: 483‐490, 2004
Vaccination of Infants and Health Beliefs of Ultra-Orthodox Mothers

Background: This study looked at mothers from the ultra-orthodox Jewish sector with the objective of obtaining information about their health beliefs and the behavior of these mothers regarding vaccination of their infants. Methods: The study took place between April- December 2009. A snowball technique of sampling was chosen, a technique that is frequently used in studies conducted among minority groups. Inclusion criteria were mothers under thirty years old. The questionnaire was filled out about children whose ages ranged from 18 months to 24 months. We contacted 127 ultra-orthodox mothers, of whom 85 (66.9%) consented to participate in the study and filled out the following questionnaires: Health Beliefs, Religious Beliefs, and demographic data. Vaccination behaviors were obtained by reviewing infant vaccination cards. Analysis of data included descriptive statistics, linear regressions and path-analysis model (SEM). Results: Most ultra-orthodox mothers vaccinate their infants against Hepatitis B (HBV-97%), polio (IPV-89.9%), Diphtheria,Tetanus, Pertussis (DTaP-89.9%), Haemophilus influenza b (Hib-89.9%), pneumococcal infections (PCV13-87.3%), Measles, Mumps, Rubella (MMR-88.6%) and Varicella (Var-88.6%). Linear regression analysis and the path analysis model revealed that a mother’s vaccination behavior at a given time (t) is influenced by her vaccination behavior at a previous time (t-1): for example, vaccination behavior up to age two months is the most powerful predictor of vaccination behavior at the age of four months. Conclusions: It seems that the mothers’ behavior toward vaccinating their infants at age two months is critical to the continued shaping and stabilization of a regimen of vaccinations over the following months.
A Novel Microwave-based Inspection System for Continuously Streaming Materials Using a Cavity Resonator

In this paper, we present a novel ultra-fast material inspection system for continuously streaming dielectric materials, such as paper, plastic films, non-aqueous liquids etc. The material stream is being passed through a cavity resonator whose electrical parameters are altered by the presence of the material, due to its interaction with the electric field inside the resonator. The latter is employed as the frequency-determining component in an amplitude-controlled oscillator circuit. Small changes in the electrical properties of the resonator due to fluctuations in the material stream cause the oscillator circuit to be detuned and damped. Monitoring the frequency of oscillation as well as the gain yields realtime information about the resonator's electrical parameters and, thus, allows assessment of material properties, such as water content, contamination, density etc.
Advances in flow cytometry for drug screening

Importance of the field: Flow cytometry is considered today as a mature technology. Recently, it has become an accurate tool for screening applications. Yet, not many studies have been published emphasizing flow cytometry as a tool of choice for drug screening except multiplex bead assay. Areas covered in this review: Scanning the literature for technology breakouts in screening by flow is not an easy task. When a private industry has an accurate and fast screening technology on hands, why should they make public a tool precious for their screening applications? On the European academic side, there are regrettably few grants to help develop and publish screening methodologies. So, a less scientific way to find out is a close market survey seeking new instruments and associated kits or new methods. From here, can one expect flow cytometry to be a tool with new potential for drug discovery? What the reader will gain: As the machines are getting simpler to use, a need for plug-and-analyze software has emerged. New analysis tools remain an important step as they will permit to analyze and compare several parameters in a multi-well format simultaneously and this for several cell types for cytomics: a multiparametric, dynamic approach to cell research as cytomics has a practical role to play in drug discovery within the immediate limitations of cell-based analyses. Take home message: Developing new software with multi-well comparison capabilities and most importantly real-time interaction on cytograms can easily circumvent the lack of fluorescent channels on small bench top machines.
Stable Games

We introduce a new class of population games called stable games. These games are characterized by self- defeating externalities: when agents revise their strategies, the improvements in the payoffs of strategies to which revising agents are switching are always exceeded by the improvements in the payoffs of strategies which revising agents are abandoning. Stable games subsume many well-known classes of examples, including zero-sum games, games with an interior ESS, wars of attrition, and concave potential games. We prove that the set of Nash equilibria of any stable game is convex. Finally, we show that the set of Nash equilibria of a stable game is globally asymptotically stable under various classes of evolutionary dynamics, classes that include the best response dynamic, the Brown-von Neumann-Nash dynamic, and the Smith dynamic.
In Vitro Evaluation of the Link Between Cell Activation State and Its Rheological Impact on the Microscale Flow of Neutrophil Suspensions.

Activated neutrophils have been reported to affect peripheral resistance, for example, by plugging capillaries or adhering to the microvasculature. In vivo and ex vivo data indicate that activated neutrophils circulating in the blood also influence peripheral resistance. We used viscometry and microvascular mimics for in vitro corroboration. The rheological impact of differentiated neutrophil-like HL-60 promyelocytes (dHL60s) or human neutrophil suspensions stimulated with 10 nM fMet-Leu-Phe (fMLP) was quantified using a cone-plate rheometer (450 s(-1) shear rate). To evaluate their impact on microscale flow resistance, we used 10-μm Isopore® membranes to model capillaries as well as single 200 × 50 μm microchannels and networks of twenty 20 × 50 μm microfluidic channels to mimic noncapillary microvasculature. Stimulation of dHL60 and neutrophil populations significantly altered their flow behavior as evidenced by their impact on suspension viscosity. Notably, hematocrit abrogated the impact of leukocyte activation on blood cell suspension viscosity. In micropore filters, activated cell suspensions enhanced flow resistance. This effect was further enhanced by the presence of erythrocytes. The resistance of our noncapillary microvascular mimics to flow of activated neutrophil suspensions was significantly increased only with hematocrit. Notably, it was elevated to a higher extent within the micronetwork chambers compared to the single-channel chambers. Collectively, our findings provide supportive evidence that activated neutrophils passing through the microcirculation may alter hemodynamic resistance due to their altered rheology in the noncapillary microvasculature. This effect is another way neutrophil activation due to chronic inflammation may, at least in part, contribute to the elevated hemodynamic resistance associated with cardiovascular diseases (e.g., hypertension and hypercholesterolemia).
Diversity of human rotavirus G9 among children in Turkey

Between September 2004 and December 2005 a prospective study was conducted to understand the epidemiology of rotavirus infection among children with diarrhea attending two hospitals in Ankara, Turkey. Rotavirus was detected in 39.7% of the 322 stool samples and affected mainly children in the age group of 6–23 months. More than 70% and 39% of these cases occurred in children <2 and <1 year of age, respectively. In the temperate climate of Ankara rotavirus infection was prevalent throughout the year. Serotype G1P[8] was dominant followed by G9P[8]. In 38 samples a total of 5 electropherotypes were detected. All G9P[8] were of long electropherotype except one of short electropherotype. A proportion of G1 and G9 strains were in combination with P[6], P[4] or P nontypable. Mixed serotypes were responsible for 2.4% of the infections. A phylogenetic tree constructed with the deduced amino acid sequences of the VP7 gene showed that 16 Turkish G9 strains clustered with rotaviruses of lineage III. One G9 strain formed a new lineage, lineage IV with the Sri Lankan G9 rotaviruses. In the phylogenetic tree of the VP8* gene, the Turkish G9P[6] rotaviruses clustered with human strains of lineage Ia. Increased diversity of the G/P type combination and the presence of infection throughout the year in Turkey was a situation similar to developing countries. The occurrence of rotavirus infection at later age and low level of mixed infections in Turkey represented the situation of developed countries. This study suggests that diverse G9 rotaviruses are emerging in Turkey. J. Med. Virol. 80:733–740, 2008. © 2008 Wiley‐Liss, Inc.
Matching Web Tables To DBpedia - A Feature Utility Study

Relational HTML tables on the Web contain data describing a multitude of entities and covering a wide range of topics. Thus, web tables are very useful for ﬁlling missing values in cross-domain knowledge bases such as DBpedia, YAGO, or the Google Knowledge Graph. Before web table data can be used to ﬁll missing values, the tables need to be matched to the knowledge base in question. This involves three matching tasks: table-to-class matching, row-to-instance matching, and attribute-to-property matching. Various matching approaches have been proposed for each of these tasks. Unfortunately, the existing approaches are evaluated using diﬀerent web table corpora. Each individual approach also only exploits a subset of the web table and knowledge base features that are potentially helpful for the matching tasks. These two shortcomings make it diﬃcult to compare the diﬀerent matching approaches and to judge the impact of each feature on the overall matching results. This paper contributes to improve the understanding of the utility of diﬀerent features for web table to knowledge base matching by reimplementing diﬀerent matching techniques as well as similarity score aggregation methods from literature within a single matching framework and evaluating diﬀerent combinations of these techniques against a single gold standard. The gold standard consists of class, instance, and property correspondences between the DBpedia knowledge base and web tables from the Web Data Commons web table corpus.
Detection tests for array processing in unknown correlated noise fields

This paper introduces two eigenvalue-based rules for estimating the number of signals impinging on an array of sensors along with a spatially correlated noise field. The first rule, called S, is derived under the assumption that the noise spatial covariance is block diagonal or banded. The assumption underlying the second detection rule, named T, is that the temporal correlation of the noise has a shorter length than that of the signals. In both cases, a matrix is built from the array output data covariances, the smallest eigenvalue of which is equal to zero under the hypothesis that the source number is overestimated. The sample distribution of the aforementioned smallest eigenvalue is derived and used to formulate the detection rules S and T. Both these rules are computationally quite simple. Additionally, they can be used with a noncalibrated array. The paper includes numerical examples that lend empirical support to the theoretical findings and illustrate the kind of performance that can be achieved by using the S and T detection rules.
Demographic, psychosocial, and objective risk factors related to perceived risk of skin cancer.

BACKGROUND AND METHODS The present study examined the ways in which demographic, psychosocial, and objective risk factors were related to perceived risk of skin cancer among 384 hospital employees who participated in a screening program. It was hypothesized that pyschosocial risk factors would account for a significant portion of the variance in risk perception beyond that accounted for by the other risk factors. RESULTS The risk factors accounted for approximately 44% of the variance in risk perception. Psychosocial risk factors accounted for a statistically significant portion of the variance in risk perception beyond that accounted for by other risk factors. Worry, family history of skin cancer, and race/ethnicity were most strongly related to perceived risk. CONCLUSIONS Results are discussed in terms of the need for educational programs that emphasize the relationship between level of risk and skin cancer and provide specific information regarding steps that can be taken to prevent skin cancer.
Opioid-induced bowel dysfunction in healthy volunteers assessed with questionnaires and MRI

Objective Opioid treatment is associated with numerous gastrointestinal adverse effects collectively known as opioid-induced bowel dysfunction (OIBD). Most current knowledge of the pathophysiology derives from animal studies limited by species differences and clinical studies, which have substantial confounders that make evaluation difficult. An experimental model of OIBD in healthy volunteers in a controlled setting is therefore highly warranted. The aim of this study was to assess bowel function in healthy volunteers during opioid treatment using subjective and objective methods. Methods Twenty-five healthy men were assigned randomly to oxycodone or placebo for 5 days in a cross-over design. The analgesic effect was assessed with muscle pressure algometry and adverse effects were measured using questionnaires including the bowel function index, gastrointestinal symptom rating scale, patient assessment of constipation symptoms and the Bristol stool form scale. Colorectal volumes were determined using a newly developed MRI method. Results Compared with baseline, oxycodone increased pain detection thresholds by 8% (P=0.02). Subjective OIBD was observed as increased bowel function index (464% increase; P<0.001), gastrointestinal symptom rating scale (37% increase; P<0.001) and patient assessment of constipation symptoms (198% increase; P<0.001). Objectively, stools were harder and drier during oxycodone treatment (P<0.001) and segmental colorectal volumes increased in the caecum/ascending colon by 41% (P=0.005) and in the transverse colon by 20% (P=0.005). No associations were detected between questionnaire scores and colorectal volumes. Conclusion Experimental OIBD in healthy volunteers was induced during oxycodone treatment. This model has potential for future interventional studies to discriminate the efficacies of different laxatives, peripheral morphine antagonists and opioid treatments.
An automated machine vision system for the histological grading of cervical intraepithelial neoplasia (CIN)

The histological grading of cervical intraepithelial neoplasia (CIN) remains subjective, resulting in inter‐ and intra‐observer variation and poor reproducibility in the grading of cervical lesions. This study has attempted to develop an objective grading system using automated machine vision. The architectural features of cervical squamous epithelium are quantitatively analysed using a combination of computerized digital image processing and Delaunay triangulation analysis; 230 images digitally captured from cases previously classified by a gynaecological pathologist included normal cervical squamous epithelium (n=30), koilocytosis (n=46), CIN 1 (n=52), CIN 2 (n=56), and CIN 3 (n=46). Intra‐ and inter‐observer variation had kappa values of 0.502 and 0.415, respectively. A machine vision system was developed in KS400 macro programming language to segment and mark the centres of all nuclei within the epithelium. By object‐oriented analysis of image components, the positional information of nuclei was used to construct a Delaunay triangulation mesh. Each mesh was analysed to compute triangle dimensions including the mean triangle area, the mean triangle edge length, and the number of triangles per unit area, giving an individual quantitative profile of measurements for each case. Discriminant analysis of the geometric data revealed the significant discriminatory variables from which a classification score was derived. The scoring system distinguished between normal and CIN 3 in 98.7% of cases and between koilocytosis and CIN 1 in 76.5% of cases, but only 62.3% of the CIN cases were classified into the correct group, with the CIN 2 group showing the highest rate of misclassification. Graphical plots of triangulation data demonstrated the continuum of morphological change from normal squamous epithelium to the highest grade of CIN, with overlapping of the groups originally defined by the pathologists. This study shows that automated location of nuclei in cervical biopsies using computerized image analysis is possible. Analysis of positional information enables quantitative evaluation of architectural features in CIN using Delaunay triangulation meshes, which is effective in the objective classification of CIN. This demonstrates the future potential of automated machine vision systems in diagnostic histopathology. Copyright © 2000 John Wiley & Sons, Ltd.
Fabrication of Textile Antennas and Circuits With 0.1 mm Precision

We present a new selection of E-fibers (also referred to as E-threads) and associated embroidery process. The new E-threads and process achieve a geometrical precision down to 0.1 mm. Thus, for the first time, accuracy of typical printed circuit board (PCB) prototypes can be achieved directly on textiles. Compared to our latest embroidery approach, the proposed process achieves: 1) 3 × higher geometrical precision; 2) 24 × lower fabrication cost; 3) 50% less fabrication time; and 4) equally good RF performance. This improvement was achieved by employing a new class of very thin, 7-filament, Elektrisola E-threads ( diameter ≈ 0.12 mm, almost 2 × thinner than before). To validate our approach, we “printed” and tested a textile spiral antenna operating between 1-5 GHz. Measurement results were in good agreement with simulations. We envision this textile spiral to be integrated within a cap and unobtrusively acquire neuropotentials from wireless fully-passive brain implants. Overall, the proposed embroidery approach brings forward new possibilities for a wide range of applications.