Miracle-dz/UniFAR-FTUs huggingface dataset:
The molecular background to hypophosphataemic rickets

Bone mineral loss disorders are major, worldwide health concerns, and can be familial, idiopathic, oncogenic, dietary, or hormonal. The mechanisms controlling bone integrity are complex. Extensive research has been directed towards the characterisation of the key factors involved in bone mineral regulation and two specific bone diseases, X-linked hypophosphataemic rickets (HYP) and oncogenic hypophosphataemic osteomalacia (OHO). The primary defect in HYP is a defective zinc metalloendopeptidase (PHEX),1-4 and a new candidate glycoprotein (MEPE) has been proposed as the phosphaturic factor released by OHO tumours.5 6 Both diseases cause severe changes in bone morphology and have an overlapping pathophysiology. This review will discuss the recent molecular advances in our understanding of the role of the kidney and other organs in bone mineral homeostasis, with emphasis on X-linked hypophosphataemic rickets and tumour osteomalacia. Classic, vitamin D resistant HYP(MIM #307800), is characterised by: OHO shares many clinical, biochemical, and physiological features with HYP.8 9 The tumours are mainly of mesenchymal origin, although a number of different tumour types have been reported.10 11 Evidence indicates that changes in renal phosphate handling, vitamin D metabolism, and skeletal mineralisation are caused by factor(s) secreted by OHO tumours.8-10 12-19 The resection of OHO tumours results in the disappearance of disease symptoms and bone healing and is a key observation that supports this.8 12 20 The rickets gene PHEX (phosphate regulating gene with endopeptidase activity on the X chromosome),1 2 is a zinc metalloendopeptidase with close homologies to an M13 family of type II glycoproteins. …
Role of snus (oral moist snuff ) in smoking cessation and smoking reduction in Sweden.

AIMS To assess to what extent snus has been used as an aid to stop smoking among Swedish smokers. DESIGN A random telephone retrospective survey of Swedish smokers and ex-smokers. SETTING Survey conducted in November-December 2000. PARTICIPANTS A national sample of 1000 former and 985 current daily smokers aged 25-55 years. MEASUREMENTS Smoking status, date and method of quitting by self-report. FINDINGS Thirty-three per cent of former smokers and 27% of current smokers had ever used snus. The difference was larger among men (55% versus 45%, P = 0.003). Current smokers who made use of snus smoked on average fewer cigarettes per day than non-users of snus. The mean duration of abstinence among former smokers was not influenced by snus use. Conditionally on age, education and use of nicotine replacement therapy there was an increased probability of being a former rather than a current smoker with ever use (OR 1.72, 95% CI = 1.30-2.28) or current use (OR 1.81, 95% CI = 1.31-2.53) of snus. Having used snus at the latest quit attempt increased the probability of being abstinent by about 50% (OR 1.54, 95% CI = 1.09-2.20). CONCLUSIONS Our study suggests that by using snus, Swedish male smokers may increase their overall chances of abstinence. However, 71% of the men in this sample who quit smoking did so without using snus and the duration of abstinence was not affected by snus use. This suggests that snus is not a necessary component of smoking cessation at the population level. Snus use was very rare among women.
Injectable simvastatin gel for minimally invasive periosteal distraction: In vitro and in vivo studies in rat

OBJECTIVES To evaluate whether the subperiosteal injection of simvastatin (SIM) with a novel in situ gel-forming system, SrHA/Alg (strontium hydroxyapatite/alginate), can stimulate vertical bone augmentation in a rat calvarial model. MATERIAL AND METHODS The SrHA/Alg solution was synthesized and combined with different doses of SIM (0.01, 0.02, 0.1, and 0.2 mg) to form the following groups: (1) SrHA/Alg only, (2) SrHA/Alg/0.01, (3) SrHA/Alg/0.02, (4) SrHA/Alg/0.1, and (5) SrHA/Alg/0.2. The SIM release pattern was analyzed, and rat primary periosteum-derived cell (PDC) responses were investigated. Twenty male Wistar rats were enrolled in the calvarial subperiosteal injection experiment with each animal receiving a 200-μl single subperiosteal injection of SrHA/Alg with different amounts of SIM (0, 0.01, 0.02, and 0.1 mg) incorporated (n = 5). The 0.2 mg dose group was not tested in vivo due to the severe toxicity found in vitro. The new bone formation was assessed histologically and radiologically at 8 weeks. RESULTS The slow release of SIM was confirmed, and PDC viability decreased in the SrHA/Alg/0.2 group. Alkaline phosphatase positive areas and mineralization areas were significantly greater in the SrHA/Alg/0.01 and SrHA/Alg/0.02 groups (p < .05). The mRNA expression level of Runx2 significantly increased in the SrHA/Alg/SIM-0.02 group by day 7 (p < .05) and significantly higher levels of VEGF were found in the SrHA/Alg/0.01 and SrHA/Alg/0.02 groups at different time points (p < .05). In vivo, no prominent clinical sign of inflammation was observed, and the most significant bone gain was shown in the SrHA/Alg/0.02 group (p < .05). The osteoclast formation within the newly formed bone area was reduced in the SrHA/Alg/0.1 group (p < .05). CONCLUSIONS When combined with SrHA/Alg system, the 0.02 mg SIM seemed to be the optimal dose to stimulate subperiosteal bone formation without inducing inflammation. This combination may hold potential therapeutic benefits for clinical bone augmentation in a minimally invasive manner.
Stimulation and desensitization of the hypothalamic heat‐sensitive structures by capsaicin in rats

1. In rats the injection of capsaicin into the pre‐optic area of the anterior hypothalamus produces a prompt fall in body temperature and abolishes shivering. With repeated injections of capsaicin the hypothermic effect gradually diminishes and finally vanishes (local desensitization).
The ratio bias phenomenon: fact or artifact?

The ratio bias—according to which individuals prefer to bet on probabilities expressed as a ratio of large numbers to normatively equivalent or superior probabilities expressed as a ratio of small numbers—has recently gained momentum, with researchers especially in health economics emphasizing the policy importance of the phenomenon. Although the bias has been replicated several times, some doubts remain about its economic significance. Our two experiments show that the bias disappears once order effects are excluded, and once salient and dominant incentives are provided. This holds true for both choice and valuation tasks. Also, adding context to the decision problem does not alter this finding. No ratio bias could be found in between-subject tests either, which leads us to the conclusion that the policy relevance of the phenomenon is doubtful at best.
Predictors of arrest during forensic assertive community treatment.

OBJECTIVE An emerging adaptation of the assertive community treatment model is forensic assertive community treatment (FACT), which aims to prevent criminal recidivism. This study examined predictors of arrest among patients in a prototype program and considered the implications of study findings for future development of the FACT model. METHODS Demographic and clinical data from all 130 patients treated in Project Link from 1997 through 2003 were merged with a statewide criminal record database to identify variables associated with arrest. RESULTS Poisson regression revealed a history of arrests for violent offenses before treatment and evictions from residential treatment, and antisocial traits were associated with arrest during treatment. Substance abuse was not associated with arrest, but the sample lacked heterogeneity for this factor. CONCLUSIONS Variables associated with arrest were similar to those seen in the general population. In the absence of a standardized model of intervention, FACT programs should incorporate interventions that target modifiable risk factors in order to prevent criminal recidivism among high-risk patients.
Gibson's "Affordances": Evolution of a Pivotal Concept

Ecological psychology applies insights of Darwinian theory and Gestalt principles to the understanding of perceptual processes. James J. Gibson developed a perceptual theory of "affordances", a neologism he adopted for the pivotal concept in a radical view of how interactive organism-environment features index the behaviors an organism may perform (perceived action possibilities). Gibson asserted “a niche is a set of affordances” (Gibson, 1986, p. 128) and affordances “are properties of the environment relative to an animal (Gibson, 1966, p. 285). In the ecological view, understanding the constraints and opportunities offered by an environs (its affordances) requires recognition of a dynamic reciprocity between an organism’s perception and specific environmental features (their demand characteristics, or “invariances”) that together form the background (situation or context) of an organismenvironment event. Affordances theory seeks both to objectify perceptual processes and to operationalize the foundational Gestalt principle of complementarity between ‘figure’ and ‘ground’. Rationales for Gibson's hybrid approach are examined, and a chronology of theory development is accompanied by review of recent refinements, criticisms, and their implications.
Cognitive Stimulation of Executive Functions in Mild Cognitive Impairment

Executive functions play an important role in the maintenance of autonomy in day-to-day activities. Nevertheless, there is little research into specific cognitive training for Mild Cognitive Impairment (MCI). We present the results of a program which aims to teach specific strategies and metacognitive abilities in order for patients to be able to carry out attentional and executive tasks. Two groups (A and B) were compared in a cross-over design. After the first evaluation, Group A (but not B) participated in a six month cognitive stimulation program. After a second assessment, only Group B received treatment and then a final evaluation was carried out on both groups. The results show that: i) both groups improved their performance as an effect of training; ii) improvements generalized to memory and general cognitive tasks; iii) in the interval without training, Group B's performance worsened and iv) Group A partially maintained their results over time.
Extremal graphs without a semi‐topological wheel

For 2≤r∈ℕ, let Sr denote the class of graphs consisting of subdivisions of the wheel graph with r spokes in which the spoke edges are left undivided. Let ex(n, Sr) denote the maximum number of edges of a graph containing no Sr‐subgraph, and let Ex(n, Sr) denote the set of all n‐vertex graphs containing no Sr‐subgraph that are of size ex(n, Sr). In this paper, a conjecture is put forth stating that for r≥3 and n≥2r + 1, ex(n, Sr) = (r − 1)n − ⌈(r − 1)(r − 3/2)⌉ and for r≥4, Ex(n, Sr) consists of a single graph which is the graph obtained from Kr − 1, n − r + 1 by adding a maximum matching to the color class of cardinality r − 1. A previous result of C. Thomassen [A minimal condition implying a special K4‐subdivision, Archiv Math 25 (1974), 210–215] implies that this conjecture is true for r = 3. In this paper it is shown to hold for r = 4. © 2011 Wiley Periodicals, Inc. J Graph Theory 68:326‐339, 2011
Alternatives to Animals in Education, Research, and Risk Assessment: An Overview with Special Reference to Indian Context

The use of animals in science is a contentious issue, with opinions from scientists, teachers, animal protectionists, and the public either to support animal experimentation or to reject/minimize it (Pawlik, 1998; Giridharan, 2000; Greek and Greek, 2010; Greek, 2012). The main purposes of animal experiments are for: basic biological knowledge; fundamental medical research; the discovery and development of drugs, vaccines, and medical devices; toxicity testing of drugs, other chemical entities, and consumer products; and education and training (Taylor et al., 2008). These contexts of animal use can be broadly classiied into (i) education and training, and (ii) research and testing. It is roughly estimated that among the several million animals sacriiced for the cause of science, in any country, 1-10% are used in education and the rest in research and testing. There has been a movement against the use of animals in endeavors in science on several grounds and, as a result, greater awareness has been generated. A concerted effort across the globe has resulted in a considerable reduction in the number of animals used and increased recognition that animals are sentient beings. It is cause to rejoice that India has made rapid strides in phasing out animal use in education and training, but the scenario with respect to research and testing has changed very little. This article is an attempt to sensitize the stakeholders to the need to promote the most humane science. 2 On the use of animals in education and training in basic sciences and the potential alternatives
DroidCat: Unified Dynamic Detection of Android Malware

Various dynamic approaches have been developed to detect or categorize Android malware. These approaches execute software, collect call traces, and then detect abnormal system calls or sensitive API usage. Consequently, attackers can evade these approaches by intentionally obfuscating those calls under focus. Additionally, existing approaches treat detection and categorization of malware as separate tasks, although intuitively both tasks are relevant and could be performed simultaneously. This paper presents DroidCat, the first unified dynamic malware detection approach, which not only detects malware, but also pinpoints the malware family. DroidCat leverages supervised machine learning to train a multi-class classifier using diverse behavioral profiles of benign apps and different kinds of malware. Compared with prior heuristics-based machine learning-based approaches, the feature set used in DroidCat is decided purely based on a systematic dynamic characterization study of benign and malicious apps. All differentiating features that show behavioral differences between benign and malicious apps are included. In this way, DroidCat is robust to existing evasion attacks. We evaluated DroidCat using leave-one-out cross validation with 136 benign apps and 135 malicious apps. The evaluation shows that DroidCat provided an effective and scalable unified malware detection solution with 81% precision, 82% recall, and 92% accuracy.
Personality prototypes and ego development: conceptual similarities and relations in adult women.

Three studies investigated how three personality prototypes (K. York & O.P. John, 1992) relate to J. Loevinger's (1976) stages of ego development (ED). Study 1 examined their conceptual similarities, and Study 2 their relations in a sample of adult women. In both studies, the personality prototypes mapped onto regions defined by multiple ED stages: The Individuated prototype was most likely to reach the high region of ED (Individualistic, Autonomous, and Integrated); the Traditional prototype was most likely to function in the middle region (Conformist, Self-aware, and Conscientious); and the Conflicted prototype was more likely to remain in the low region (Impulsive and Self-protective). In addition to these between-prototype differences, Study 3 explored whether differences in life outcomes within the prototypes are also related to ED; findings suggest that personality prototype and ego development may interact in shaping the life course.
Network Characteristics of Successful Performance in Association Football. A Study on the UEFA Champions League

The synergistic interaction between teammates in association football has properties that can be captured by Social Network Analysis (SNA). The analysis of networks formed by team players passing a ball in a match shows that team success is correlated with high network density and clustering coefficient, as well as with reduced network centralization. However, oversimplification needs to be avoided, as network metrics events associated with success should not be considered equally to those that are not. In the present study, we investigated whether network density, clustering coefficient and centralization can predict successful or unsuccessful team performance. We analyzed 12 games of the Group Stage of UEFA Champions League 2015/2016 Group C by using public records from TV broadcasts. Notational analyses were performed to categorize attacking sequences as successful or unsuccessful, and to collect data on the ball-passing networks. The network metrics were then computed. A hierarchical logistic-regression model was used to predict the successfulness of the offensive plays from network density, clustering coefficient and centralization, after controlling for the effect of total passes on successfulness of offensive plays. Results confirmed the independent effect of network metrics. Density, but not clustering coefficient or centralization, was a significant predictor of the successfulness of offensive plays. We found a negative relation between density and successfulness of offensive plays. However, reduced density was associated with a higher number of offensive plays, albeit mostly unsuccessful. Conversely, high density was associated with a lower number of successful offensive plays (SOPs), but also with overall fewer offensive plays and “ball possession losses” before the attacking team entered the finishing zone. Independent SNA of team performance is important to minimize the limitations of oversimplifying effective team synergies.
A Conceptual Study on Hospital Information System in Public Hospital of Bangladesh: Electronic Medical Record and Clinical Information System Perspective

The empirical data is used in organizations all over the world which require the integration of some informational systems like Electronic Medical Record (EMR) and Clinical Information System (CIS); these concepts will discover with new form of Bangladeshi public hospital’s improvement in Information Technology (IT) sector. The objective of this conceptual paper is to review critically and identify the gaps in current literature aligning with Hospital Information System (HIS) and Electronic Medical Record (EMR), building relationship between EMR and CIS in terms of Bangladeshi public hospital; towards hospital’s effectiveness of service operator when public hospital plays an important role to keep the patients data. The proposed conceptual framework assists HIS providers to understand how EMR and CIS can contribute to improve the hospitals patient database. More over the paper presents an analysis in various aspects of EMR and CIS complying with a conceptual framework which can attract the researchers in Hospital information System field and public hospital management field for the better presences of information technology for the patients. Hospital Information System (HIS) is essential in hospitals especially which deals with high-quality healthcare treatments. HIS helps to improve patients care services. Thus, the Bangladesh Government has not introduced any kind of HIS for public hospitals of Bangladesh. Moreover, there is no study on HIS implementation in Bangladeshi public hospital.
Neosartorya udagawae (Aspergillus udagawae), an Emerging Agent of Aspergillosis: How Different Is It from Aspergillus fumigatus?

ABSTRACT A recent report on several cases of invasive aspergillosis caused by Neosartorya udagawae suggested distinctive patterns of disease progression between N. udagawae and Aspergillus fumigatus. This prompted us to characterize N. udagawae in comparison to A. fumigatus. Our findings showed that both species exist in two mating types at similar ratios and produce gliotoxin. However, the thermotolerance of the two species differs: while A. fumigatus is able to grow at 55°C but not at 10°C, N. udagawae is able to grow at 10°C but fails to grow at >42°C. Furthermore, compared to A. fumigatus, the conidia of N. udagawae require longer incubation periods to germinate at 37°C and are more susceptible to neutrophil attack as well as hydrogen peroxide; N. udagawae is also less virulent in gp91phox−/− mice. These findings suggest that growth and susceptibility to the host response might account for the reduced virulence of N. udagawae and the subtle distinction in the progression of the disease caused by the two species.
Global and Regional Estimates of Prevalent and Incident Herpes Simplex Virus Type 1 Infections in 2012

Background Herpes simplex virus type 1 (HSV-1) commonly causes orolabial ulcers, while HSV-2 commonly causes genital ulcers. However, HSV-1 is an increasing cause of genital infection. Previously, the World Health Organization estimated the global burden of HSV-2 for 2003 and for 2012. The global burden of HSV-1 has not been estimated. Methods We fitted a constant-incidence model to pooled HSV-1 prevalence data from literature searches for 6 World Health Organization regions and used 2012 population data to derive global numbers of 0-49-year-olds with prevalent and incident HSV-1 infection. To estimate genital HSV-1, we applied values for the proportion of incident infections that are genital. Findings We estimated that 3709 million people (range: 3440–3878 million) aged 0–49 years had prevalent HSV-1 infection in 2012 (67%), with highest prevalence in Africa, South-East Asia and Western Pacific. Assuming 50% of incident infections among 15-49-year-olds are genital, an estimated 140 million (range: 67–212 million) people had prevalent genital HSV-1 infection, most of which occurred in the Americas, Europe and Western Pacific. Conclusions The global burden of HSV-1 infection is huge. Genital HSV-1 burden can be substantial but varies widely by region. Future control efforts, including development of HSV vaccines, should consider the epidemiology of HSV-1 in addition to HSV-2, and especially the relative contribution of HSV-1 to genital infection.
Dopamine as the wind of the psychotic fire: new evidence from brain imaging studies

Abnormalities of dopamine function in schizophrenia are suggested by the common antidopaminergic properties of antipsychotic medications. However, direct evidence of a hyperdopaminergic state in schizophrenia has been diffcult to demonstrate, given the diffculty of measuring dopamine transmission in the living human brain. This situation is rapidly changing. Recent developments in positron emission tomography and single-photon emission tomographic techniques enabled measurement of acute fluctuation of synaptic dopamine in the vicinity of D2 receptors. Using this technique, we, and others, measured the increase in dopamine transmission following aute amphetamine challenge in untreated patients with schizophrenia and matched healthy subjects. Following a brief overview of these new brain imaging techniques, the main results derived with this method in patients with schizophrenia are described: (1) amphetamine-induced dopamine release is elevated in patients with schizophrenia, supporting the idea that schizophrenia is associated with dysregulation of dopamine transmission; (2) following amphetamine, hyperactivity of dopamine transmission is associated with activation of psychotic symptomatology; (3) this dysregulation of dopamine release is not a long-term consequence of previous neuroleptic treatment, and is detected in never-medicated patients experiencing a first episode of the illness; and (4) in contrast, this exaggerated response of the dopamine system to amphetamine exposure is not detected in patients studied during a period of illness stabilization, suggesting that the hyperdopaminergic state associated with schizophrenia fluctuates over time. In conclusion, a hyperdopaminergic state might be present in schizophrenia during the initial episode and subsequent relapses, but not during periods of remission. This finding has important consequences for the development of new treatment strategies for the remission phase.