Miracle-dz/UniFAR-FTUs huggingface dataset:
Journal of Knowledge Management Knowledge management and succession planning in SMEs

Purpose – An ignorance of knowledge attrition caused by employee exits is considered as careless and can lead to considerable consequences regarding both a firm’s financial capital and intellectual capital, or in other words an ignorance of the danger of knowledge loss is associated with a missing or improper succession planning. The purpose of this study is to gain a better understanding of how a medium-sized firm copes with the danger of knowledge loss due to employee exit or long-term absence. Design/methodology/approach – Data were obtained through semi-structured interviews with 14 organization members from a German medium-sized enterprise operating in the printing sector. These participants represented different departments and positions. Findings – The findings demonstrate the influence of a precarious financial situation on activities related to knowledge management and succession planning. Although the organization members are aware of obvious needs for improvement within the firm, their actual scope of action is centered on the execution of current orders. Research limitations/implications – The data are cross-sectional and were collected in one organization. Future studies should consider longitudinal designs across multiple organizations. Practical implications – Based on the findings some suggestions were derived that may help firms facing similar circumstances. Originality/value – The study’s findings provide fresh insights into how an established firm tackles the issue of knowledge attrition and its likely implications for the firm’s performance.
Sentiment Analysis And Deep Learning A Survey

Text Analytics with PythonSentiment Analysis in the Bio-Medical DomainSentiment Analysis in Social NetworksAffective Computing and Deep Learning to Perform Sentiment AnalysisLifelong Machine LearningMachine Learning for TextComparison of neutrosophic approach to various deep learning models for sentiment analysisThe Study of Social Media, Deep Learning and Sentiment Analysis for the Methods of Personalized RecommendationSupervised Machine Learning for Text Analysis in RDeep Learning-based Approaches for Sentiment AnalysisNatural Language Processing RecipesMultimodal Sentiment AnalysisTensorFlow Machine Learning CookbookNew Opportunities for Sentiment Analysis and Information ProcessingMulti-way Factorization Machine for Sentiment AnalysisPython Machine LearningSentiment AnalysisSentiment Analysis on Twitter Data Using Machine LearningComputational Intelligence Applications for Text and Sentiment Data AnalysisText Analytics with PythonSocial Media Sentiment Analysis with a Deep Neural NetworkDeep Learning in Natural Language ProcessingApplied Text Analysis with PythonSentimental Analysis and Deep LearningProminent Feature Extraction for Sentiment AnalysisAcoustic Feature-based Sentiment Analysis of Call Center DataDataset Augmentation for Aspect Level Sentiment AnalysisDeep Belief Networks for Sentiment AnalysisAspect-based Sentiment Analysis for Arabic Reviews Using Deep LearningVisual and Text Sentiment Analysis through Hierarchical Deep Learning NetworksAn Evaluation of Machine Learning Algorithms for Tweet Sentiment AnalysisSentiment Analysis of Movie Reviews with Deep Learning MethodsDeep Learning-Based Approaches for Sentiment AnalysisMachine Learning Algorithms and ApplicationsSentimental Analysis and Deep LearningConducting Sentiment AnalysisSentiment Analysis for Social MediaSupervised Machine Learning for Text Analysis in RDeep Learning Models and its application: An overview with the help of R software: Second in series (Machine Learning)Big Data Analysis and Deep Learning Applications
Light polymerization-dependent changes in color and translucency of resin composites.

PURPOSE To determine the influence of type of polymerization light on changes in color and translucency of resin composites. METHODS 16 shades of commercial composites were analyzed. Specimens were polymerized with quartz-tungsten-halogen (QTH) and light-emitting diode (LED) polymerization light. Color of non-polymerized and polymerized composites was measured against white and black backgrounds using a spectroradiometer. Changes in color (deltaE'), translucency (deltaTP') and color parameters (deltaL', deltaC' and deltah') were calculated for each polymerization light. The differences among deltaE' values and among deltaTP' values obtained for each device were analyzed by two-way ANOVA. Multiple regression analysis was used to determine the influence of color parameters on deltaE' and deltaTP'. RESULTS The results indicated that there was significant difference among the deltaE' and deltaTP' values obtained using QTH and LED light polymerization (P< 0.05). The prediction equations for deltaE' and deltaTP' based on the multiple regression analyses indicated that deltaE' was mainly caused by deltaC' for both lights. However deltaTP' was mainly caused by deltah' for LED light and by the deltaC' for QTH light. Changes in translucency significantly influenced the overall color changes after polymerization.
Is it cost-effective to increase aspirin use in outpatient settings for primary or secondary prevention? Simulation data from the REACH Registry Australian Cohort.

AIMS To describe aspirin use in primary and secondary prevention and to determine the incremental costs-effectiveness ratio (ICER) per life year gain (LYG) of aspirin use among subjects with, or at high risk of atherothrombotic disease. DESIGN AND SUBJECTS To project the cost-effectiveness of aspirin over 5 years of follow-up, a Markov state transition model was developed with yearly cycles and the following health states: "Alive" (post-CAD) and "Dead. " The model compared current coverage observed among 2361 subjects using the prospective Australian subset of Reduction of Atherothrombosis for continued Health (REACH) registry, and hypothetical situation whereby all subjects assumed to be treated. Costs were calculated based on the Australian government reimbursed data for 2010. MAIN OUTCOME MEASURES ICER per LYG for increased use of aspirin. RESULTS The use of aspirin in current group varied from 67% to 70%. The base-case analysis showed that increasing aspirin use among subjects with existing CAD in outpatient settings was cost saving, while increasing use of aspirin in primary prevention equated to an ICER of AUD 7126 per LYG. CONCLUSION Among subjects with existing CAD aspirin use was shown to be a dominant choice of treatment. However, among patients without existing cardiovascular disease (primary prevention), increased uptake of aspirin was cost effective but with uncertain benefit, with two hemorrhagic bleeding events occurring for every life saved.
When Is Carotid Angioplasty and Stenting the Cost-Effective Alternative for Revascularization of Symptomatic Carotid Stenosis? A Canadian Health System Perspective

BACKGROUND AND PURPOSE: Carotid revascularization procedures can be complicated by stroke. Additional disability adds to the already high costs of the procedure. To weigh the cost and benefit, we estimated the cost-utility of carotid angioplasty and stenting compared with carotid endarterectomy among patients with symptomatic carotid stenosis, with special emphasis on scenario analyses that would yield carotid angioplasty and stenting as the cost-effective alternative relative to carotid endarterectomy. MATERIALS AND METHODS: A cost-utility analysis from the perspective of the health system payer was performed by using a Markov analytic model. Clinical estimates were based on a meta-analysis. The procedural costs were derived from a microcosting data base. The costs for hospitalization and rehabilitation of patients with stroke were based on a Canadian multicenter study. Utilities were based on a randomized controlled trial. RESULTS: In the base case analysis, carotid angioplasty and stenting were more expensive (incremental cost of $6107) and had a lower utility (−0.12 quality-adjusted life years) than carotid endarterectomy. The results are sensitive to changes in the risk of clinical events and the relative risk of death and stroke. Carotid angioplasty and stenting were more economically attractive among high-risk surgical patients. For carotid angioplasty and stenting to become the preferred option, their costs would need to fall from more than $7300 to $4350 or less and the risks of the periprocedural and annual minor strokes would have to be equivalent to that of carotid endarterectomy. CONCLUSIONS: In the base case analysis, carotid angioplasty and stenting were associated with higher costs and lower utility compared with carotid endarterectomy for patients with symptomatic carotid stenosis. Carotid angioplasty and stenting were cost-effective for patients with high surgical risk.
Purification and characterization of macrolide 2'-phosphotransferase from a strain of Escherichia coli that is highly resistant to erythromycin

Macrolide 2'-phosphotransferase [MPH(2')] was purified 90-fold from an erythromycin-resistant strain of Escherichia coli, and its enzymatic properties were investigated. MPH(2') is an inducible intracellular enzyme which showed high levels of activity with 14-member-ring macrolides and extremely low levels with 16-member-ring macrolides. The optimum pH for inactivation of oleandomycin was 8.2, and the optimum temperature of the reaction was 40 degrees C. Enzyme activity was lost by heat treatment at 50 degrees C for 1 min. The isoelectric point and molecular weight of the enzyme were 5.3 and 34,000, respectively. Purine nucleotides, such as GTP, ITP, and ATP, were effective as cofactors in the inactivation of macrolides. Iodine, EDTA, or divalent cations inhibited MPH(2') activity.
Inflation and the Stock Market: Understanding the 'Fed Model'

The so-called Fed model postulates that the dividend or earnings yield on stocks should equal the yield on nominal Treasury bonds, or at least that the two should be highly correlated. In US data there is indeed a strikingly high time series correlation between the yield on nominal bonds and the dividend yield on equities. This positive correlation is often attributed to the fact that both bond and equity yields comove strongly and positively with expected inflation. Contrary to some of the extant literature, we show that this effect is consistent with modern asset pricing theory incorporating uncertainty about real growth prospects and habit-based risk aversion. In the US, high expected inflation has tended to coincide with periods of heightened uncertainty about real economic growth and unusually high risk aversion, both of which rationally raise equity yields.
Developmental increase in D1‐like dopamine receptor‐mediated inhibition of glutamatergic transmission through P/Q‐type channel regulation in the basal forebrain of rats

Whole‐cell patch‐clamp recordings of non‐N‐methyl‐d‐aspartate glutamatergic excitatory postsynaptic currents (EPSCs) were carried out from cholinergic neurons in slices of basal forebrain (BF) of developing rats aged 21–42 postnatal days to elucidate postnatal developmental change in Ca2+ channel subtypes involved in the transmission as well as that in dopamine D1‐like receptor‐mediated presynaptic inhibition. The amplitude of EPSCs was inhibited by bath application of ω‐conotoxin GVIA (ω‐CgTX; 3 μm) or ω‐agatoxin‐TK (ω‐Aga‐TK; 200 nm) throughout the age range examined, suggesting that multiple types of Ca2+ channel are involved in the transmission. The EPSC fraction reduced by ω‐CgTX decreased with age, whereas that reduced by ω‐Aga‐TK increased. Inhibition of the EPSCs by a D1‐like receptor agonist, SKF 81297 (SKF; 30 μm) increased with age in parallel with the increase in ω‐Aga‐TK‐induced inhibition. An activator of the adenylyl cyclase (AC) pathway, forskolin (FK; 10 μm) inhibited the EPSCs, and FK‐induced inhibition also increased with age in parallel with the increase in SKF‐induced inhibition. Throughout the age range examined, SKF showed no further inhibitory effect on the EPSCs after ω‐Aga‐TK‐ or FK‐induced effect had reached steady‐state. These findings suggest that D1‐like receptor‐mediated presynaptic inhibition of glutamate release onto cholinergic BF neurons increases with age, and that the change is coupled with a developmental increase in the contribution of P/Q‐type Ca2+ channels as well as a developmental increase in AC pathway contribution.
Variable Tick Protein in Two Genomic Groups of the Relapsing Fever Spirochete Borrelia hermsii in Western North America

ABSTRACT Borrelia hermsii is the primary cause of tick-borne relapsing fever in North America. When its tick vector, Ornithodoros hermsi, acquires these spirochetes from the blood of an infected mammal, the bacteria switch their outer surface from one of many bloodstream variable major proteins (Vmps) to a unique protein, Vtp (Vsp33). Vtp may be critical for successful tick transmission of B. hermsii; however, the gene encoding this protein has been described previously in only one isolate. Here we identified and sequenced the vtp gene in 31 isolates of B. hermsii collected over 40 years from localities throughout much of its known geographic distribution. Seven major Vtp types were found. Little or no sequence variation existed within types, but between them significant variation was observed, similar to the pattern of diversity described for the outer surface protein C (OspC) gene in Lyme disease spirochetes. The pattern of sequence relatedness among the Vtp types was incongruent in two branches compared to two genomic groups identified among the isolates by multilocus sequence typing of the 16S rRNA, flaB, gyrB, and glpQ genes. Therefore, both horizontal transfer and recombination within and between the two genomic groups were responsible for some of the variation observed in the vtp gene. O. hermsi ticks were capable of transmitting spirochetes in the newly identified genomic group. Therefore, given the longevity of the tick vector and persistent infection of spirochetes in ticks, these arthropods rather than mammals may be the likely host where the exchange of spirochetal DNA occurs.
Cervical screening in England: The past, present, and future

Cervical screening in England commenced in a disorganized fashion in 1964. The flaws of this approach became apparent in the mid‐1980s and led to the inception of the National Health Service Cervical Screening Programme (NHSCSP). The main features of this program are its population‐based registry, accessibility to all women within the screening age range, its systematic process of call and recall, national coordination, and quality assurance. Its success is in part based on its ability to evolve as evidence necessitates, and throughout the period of 2000‐2010, it embarked upon a series of developments involving liquid‐based cytology, which also provided the means to conduct reflex high‐risk human papillomavirus (HR‐HPV) testing and the potential to automate the screening process. As a result of evidence acquired since 2000, the NHSCSP is currently based on a system of primary cytology with HPV triage for low‐grade abnormalities combined with cytology plus a HR‐HPV “test of cure” for women who have received treatment for cervical intraepithelial neoplasia. Future challenges for the program will involve finding solutions to increasing screening uptake among women <30 years of age—a problem that may be exacerbated when vaccinated women reach the screening age, while making plans to accommodate HPV primary screening. Cancer (Cancer Cytopathol) 2012;. © 2012 American Cancer Society.
The Skin-Mucus Microbial Community of Farmed Atlantic Salmon (Salmo salar)

The skin of the teleost is a flexible and scaled structure that protects the fish toward the external environment. The outermost surface of the skin is coated with mucus, which is believed to be colonized by a diverse bacterial community (commensal and/or opportunistic). Little is known about such communities and their role in fish welfare. In aquaculture, fish seem to be more susceptible to pathogens compared to wild fish. Indeed common fish farming practices may play important roles in promoting their vulnerability, possibly by causing changes to their microbiomes. In the present study, 16S rRNA gene amplicon sequencing was employed to analyze the composition of the farmed Salmo salar skin-mucus microbiome before and after netting and transfer. The composition of the bacterial community present in the rearing water was also investigated in order to evaluate its correlation with the community present on the fish skin. Our results reveal variability of the skin-mucus microbiome among the biological replicates before fish handling. On the contrary, after fish handling, the skin-mucus community exhibited structural similarity among the biological replicates and significant changes were observed in the bacterial composition compared to the fish analyzed prior to netting and transfer. Limited correlation was revealed between the skin-mucus microbiome and the bacterial community present in the rearing water. Finally, analysis of skin-mucus bacterial biomasses indicated low abundance for some samples, highlighting the need of caution when interpreting community data due to the possible contamination of water-residing bacteria.
[Taking decisions at the end of life. A survey of the attitude of critically ill patients against death].

BACKGROUND AND OBJECTIVE An attitude of refusal regarding death still persists in our society and the majority of patients do not usually take decisions related to the end of life. SUBJECTS AND METHOD From June 1st to December 31st, 2000, 88 first-degree relatives were interviewed concerning patient's preparation before his/her death. Patients considered to be candidates to take decisions about end of life were those with poor quality of life and previously admitted to the intensive care unit (ICU). Relatives were interviewed regarding organ donation, vital willingness, legal representative, civil willingness and patient's knowledge of disease and wish to limit therapeutic efforts in case of extreme severity. Previous quality of life was measured according to the Karnofsky scale. RESULTS 20% patients had donated organs, none had vital willingness and 44% had civil willingness. When patients were divided into groups of those with and without legal willingness, vital representative, and willgness to donate organs and to limit therapeutic effort, there were no statistically significant differences except for patients with vital representatives who were significantly younger. CONCLUSIONS Society needs to advance progressively towards the acceptance and preparation of death, so that decisions taken at the end of life, particularly in the ICUs, may represent, as accurately as possible, a patient's scale of values.
In vitro osteosarcoma biosensing using THz time domain spectroscopy

Terahertz time domain spectroscopy (THz-TDS) has a wide range of applications from semiconductor diagnostics to biosensing. Recent attention has focused on bio-applications and several groups have noted the ability of THz-TDS to differentiate basal cell carcinoma tissue from healthy dermal tissue ex vivo. The contrast mechanism is unclear but has been attributed to increased interstitial water in cancerous tissue. In this work we investigate the THz response of human osteosarcoma cells and normal human bone cells grown in culture to isolate the cells' responses from other effects. A classification algorithms based on a frequency selection by genetic algorithm is used to attempt to differentiate between the cell types based on the THz spectra. Encouraging preliminary results have been obtained.
Clearance of Helicobacter pylori Infection and Resolution of Postimmunization Gastritis in a Kinetic Study of Prophylactically Immunized Mice

ABSTRACT Patients infected with Helicobacter pylori mount an immune response which fails to clear the infection and may contribute to disease. Mice can be protected by immunization. To further characterize the H. pylori-mouse model, stomachs of unimmunized or intranasally immunized C57BL/6 mice were quantitatively cultured 3 days and 1, 2, 4, 8, 16, 32, and 52 weeks after challenge with H. pylori. At 3 days and 1 week after challenge, colonization was the same in the immunized and unimmunized mice. By 2 weeks after challenge, the immunized mice had a >2-log decrease in bacterial load, and at all later time points, they either were culture negative or had at least a 2-log decrease in bacterial load. Gastritis in the immunized mice peaked at 1 to 2 weeks after challenge and was characterized by a mixed inflammatory infiltrate and epithelial proliferation centered at the transition between corpus and antrum. By 52 weeks postchallenge, the gastric histology in the immunized mice was not different from that in control unchallenged mice. The unimmunized group began to show a reduction in bacterial load as early as 16 weeks after challenge, and by 52 weeks seven of eight unimmunized mice had developed gastritis and reduced bacterial loads. These results indicate that prophylactic immunization does not prevent colonization by H. pylori but enables mice to clear the infection or significantly reduce the number of colonizing bacteria. The reduction in bacterial load is associated with gastric inflammation that subsides over time.
Linifanib: current status and future potential in cancer therapy

Angiogenesis is one of the major mechanisms controlling tumor proliferation and metastatic spreading. Targeting of pro-angiogenic factors and their downstream effectors represents an appealing therapeutic option in the treatment of different cancer types. Linifanib (ABT-869) is a novel tyrosine-kinase inhibitor (TKI) inhibitor and its anti-angiogenic activity has been explored in numerous clinical trials. Here, we review preclinical development of linifanib focusing on its pharmacodynamic and pharmacokinetic characteristics and briefly summarize its evaluation in clinical trials. Linifanib selectively targets VEGFR and PDGFR and has low off-target inhibitory activity. Preclinical and early-phase trials have been showing promising efficacy results However, although signals of anti-tumor activity have been proven in some malignancies, linifanib late-phase development has been facing some challenges due to limited efficacy and increased toxicities. New strategies aimed at finding biomarkers of response and minimizing toxicities are needed to allow the further development of a promising compound.