Miracle-dz/UniFAR-FTUs huggingface dataset:
The “Creative Right Brain” Revisited: Individual Creativity and Associative Priming in the Right Hemisphere Relate to Hemispheric Asymmetries in Reward Brain Function

The idea that creativity resides in the right cerebral hemisphere is persistent in popular science, but has been widely frowned upon by the scientific community due to little empirical support. Yet, creativity is believed to rely on the ability to combine remote concepts into novel and useful ideas, an ability which would depend on associative processing in the right hemisphere. Moreover, associative processing is modulated by dopamine, and asymmetries in dopamine functionality between hemispheres may imbalance the expression of their implemented cognitive functions. Here, by uniting these largely disconnected concepts, we hypothesize that relatively less dopamine function in the right hemisphere boosts creativity by releasing constraining effects of dopamine on remote associations. Indeed, participants with reduced neural responses in the dopaminergic system of the right hemisphere (estimated by functional MRI in a reward task with positive and negative feedback), displayed higher creativity (estimated by convergent and divergent tasks), and increased associative processing in the right hemisphere (estimated by a lateralized lexical decision task). Our findings offer unprecedented empirical support for a crucial and specific contribution of the right hemisphere to creativity. More importantly our study provides a comprehensive view on potential determinants of human creativity, namely dopamine-related activity and associative processing.
The incidence of halothane sensitivity in British pigs

An adverse reaction in pigs to the anaesthetic halothane at approximately 8 weeks of age appears to be controlled by a single recessive gene affecting stress susceptibility, lean content and reproductive performance. In a survey of British nucleus herds, a total of 2998 pigs between 5 weeks of age and 28 kg live weight were given 3-min halothane tests during visits to 17 breeders or companies. There were no positive halothane reactions among 764 Large Whites from 7 herds. The frequency of positive reaction among 1538 Landrace from 14 herds averaged 11%, with a range from 0 to 23 % in individual herds. Frequencies in other pure breeds or synthetic lines varied from 0 to 88%. British and foreign breeds are compared, and the possibility of eliminating the halothane gene is discussed.
Sensorimotor Network Crucial for Inferring Amusement from Smiles

Abstract Understanding whether another's smile reflects authentic amusement is a key challenge in social life, yet, the neural bases of this ability have been largely unexplored. Here, we combined transcranial magnetic stimulation (TMS) with a novel empathic accuracy (EA) task to test whether sensorimotor and mentalizing networks are critical for understanding another's amusement. Participants were presented with dynamic displays of smiles and explicitly requested to infer whether the smiling individual was feeling authentic amusement or not. TMS over sensorimotor regions representing the face (i.e., in the inferior frontal gyrus (IFG) and ventral primary somatosensory cortex (SI)), disrupted the ability to infer amusement authenticity from observed smiles. The same stimulation did not affect performance on a nonsocial task requiring participants to track the smiling expression but not to infer amusement. Neither TMS over prefrontal and temporo‐parietal areas supporting mentalizing, nor peripheral control stimulations, affected performance on either task. Thus, motor and somatosensory circuits for controlling and sensing facial movements are causally essential for inferring amusement from another's smile. These findings highlight the functional relevance of IFG and SI to amusement understanding and suggest that EA abilities may be grounded in sensorimotor networks for moving and feeling the body.
Lack of adaptation during prolonged split‐belt locomotion in the intact and spinal cat

During split‐belt locomotion in humans where one leg steps faster than the other, the symmetry of step lengths and double support periods of the slow and fast legs is gradually restored. When returning to tied‐belt locomotion, there is an after‐effect, with a reversal in the asymmetry observed in the early split‐belt period, indicating that the new pattern was stored within the central nervous system. In this study, we investigated if intact and spinal‐transected cats show a similar pattern of adaptation to split‐belt locomotion by measuring kinematic variables and electromyography before, during and after 10 min of split‐belt locomotion. The results show that cats do not adapt to prolonged split‐belt locomotion. Our results suggest an important physiological difference in how cats and humans respond to prolonged asymmetric locomotion.
Stock selection using data envelopment analysis

Purpose – The purpose of this study is to adopt data envelopment analysis (DEA) to construct portfolios, and compare their return rates with the market index to examine whether DEA portfolios created superior returns. In addition, this study investigated whether using the “size effect” as a stock selection strategy is appropriate in Taiwan.Design/methodology/approach – This study applied two DEA models to evaluate the efficiency of the firms and construct portfolios by selecting stocks with high efficiency. Furthermore, the return rates of the portfolios constructed by small‐size firms, DEA models and market indices were compared via empirical data analysis.Findings – The results showed that size effect seems inappropriate as a stock selection strategy in the Taiwan stock market. However, the portfolios constructed by DEA models achieved noticeable superior returns.Research limitations/implications – Future studies can apply DEA models to other stock markets in different countries to confirm the effective.
Intravital investigation of rat mesenteric small artery tone and blood flow

Substantial information on rat mesenteric small artery physiology and pharmacology based on in vitro experiments is available. Little is known about the relevance of this for artery function in vivo. We here present an intravital model where rat mesenteric small artery diameters are studied under isolated and controlled conditions in situ with simultaneous measurement of blood flow. The responses of the isolated arteries vary with the anaesthetic used, and they are quantitatively but not qualitatively different from the responses seen in vitro.
Inducible satellite cell depletion attenuates skeletal muscle regrowth following a scald‐burn injury

Severe burns result in significant skeletal muscle cachexia that impedes recovery. Activity of satellite cells, skeletal muscle stem cells, is altered following a burn injury and likely hinders regrowth of muscle. Severe burn injury induces satellite cell proliferation and fusion into myofibres with greater activity in muscles proximal to the injury site. Conditional depletion of satellite cells attenuates recovery of myofibre area and volume following a scald burn injury in mice. Skeletal muscle regrowth following a burn injury requires satellite cell activity, underscoring the therapeutic potential of satellite cells in the prevention of prolonged frailty in burn survivors.
The evolutionary process and collaboration in supply chains

Purpose – The primary aim of this paper is to investigate the evolutionary process and collaboration within Taiwan's cut‐flower supply chains. The paper also go on to discuss the enablement of supply chain coordination through information technology (IT) adoption and network effects, as well as performance improvements achieved by the introduction of the wholesale information sharing hotline (WISH) system.Design/methodology/approach – This paper examines the evolutionary process in Taiwan's cut‐flower supply chains from a macro‐study perspective, based upon primary data obtained from in‐depth interviews. The paper also applies multiple regression analyses from a micro‐study perspective, in order to gain insights into the evolution of market share within the supply chains, thereby facilitating the investigation of the effectiveness of the WISH system.Findings – The results reveal that the auction houses are heavily dependent upon reliable sources of supply, and that in the earlier stages of the evolutionar.
Intrathecal antibody distribution in the rat brain: surface diffusion, perivascular transport and osmotic enhancement of delivery

It is unclear precisely how macromolecules (e.g. endogenous proteins and exogenous immunotherapeutics) access brain tissue from the cerebrospinal fluid (CSF). We show that transport at the brain–CSF interface involves a balance between Fickian diffusion in the extracellular spaces at the brain surface and convective transport in perivascular spaces of cerebral blood vessels. Intrathecally‐infused antibodies exhibited size‐dependent access to the perivascular spaces and tunica media basement membranes of leptomeningeal arteries. Perivascular access and distribution of full‐length IgG could be enhanced by intrathecal co‐infusion of hyperosmolar mannitol. Pores or stomata present on CSF‐facing leptomeningeal cells ensheathing blood vessels in the subarachnoid space may provide unique entry sites into the perivascular spaces from the CSF. These results illuminate new mechanisms likely to govern antibody trafficking at the brain–CSF interface with relevance for immune surveillance in the healthy brain and insights into the distribution of therapeutic antibodies.
Supraspinal modulation of neuronal synchronization by nociceptive stimulation induces an enduring reorganization of dorsal horn neuronal connectivity

The state of central sensitization induced by the intradermic injection of capsaicin leads to structured (non‐random) changes in functional connectivity between dorsal horn neuronal populations distributed along the spinal lumbar segments in anaesthetized cats. The capsaicin‐induced changes in neuronal connectivity and the concurrent increase in secondary hyperalgesia are transiently reversed by the systemic administration of small doses of lidocaine, a clinically effective procedure to treat neuropathic pain. The effects of both capsaicin and lidocaine are greatly attenuated in spinalized preparations, showing that supraspinal influences play a significant role in the shaping of nociceptive‐induced changes in dorsal horn functional neuronal connectivity. We conclude that changes in functional connectivity between segmental populations of dorsal horn neurones induced by capsaicin and lidocaine result from a cooperative adaptive interaction between supraspinal and spinal neuronal networks, a process that may have a relevant role in the pathogenesis of chronic pain and analgesia.
Selection, implementation and use of ERP systems for supply chain performance management

– The paper aims to explore how supply chain performance management (PM) is affected by the decisions made in the enterprise resource planning (ERP) system lifecycle phases. , – Data were collected in a multiple case study of four manufacturing companies. , – Four PM activities and three ERP system lifecycle phases were described and analyzed. Eight propositions were generated from theory and the case analyses. Detailed demand specifications could have improved target setting and reporting possibilities, PM education and training seem to be important in both the implementation and the use phase and supply chain PM is highly affected in the use phase. , – The paper is explorative. A required next step would be to test the generated propositions on a larger population. , – Propositions of what supply chain PM issues manufacturing companies should consider in the ERP system selection, implementation and use phases are presented. The results indicate that a lot of supply chain PM improvements can be realized within the use phase of an existing ERP system. , – No previous paper has focused upon how to consider supply chain PM when implementing ERP systems. This is needed because previous studies have identified ERP systems as obstacles for supply chain PM.
Managerial Networks and Strategic Flexibility: A QM Perspective

Purpose – The paper aims to study the effect of external managerial social networks on strategic flexibility for a quality management (QM) perspective. External social networks can affect strategic flexibility positively. QM also contributes to developing these networks. However, there is currently a wide variety of alternatives for managing quality in organizations, such as ISO standards or the European Foundation for Quality Management model. Thus, different alternatives will influence the external social networks differently in ways that have repercussions for strategic flexibility. Testing these differences is the main purpose of this paper.Design/methodology/approach – A total of 203 valid responses were classified in three groups: non‐QM, ISO, and total quality management (TQM) firms. Then, a comparative ANOVA analysis was performed to test differences among groups. Finally, different regressions were run to test the effects of external social networks (range, size and strength) on strategic flexibi.
The multidimensionality of spiritual wellbeing: peace, meaning, and faith and their association with quality of life and coping in oncology

This study explored associations between the recently proposed three‐factor structure of the 12‐item Functional Assessment of Chronic Illness Therapy—Spiritual Well‐being (FACIT‐Sp) subscale (Peace, Meaning, and Faith), quality of life (QoL), and coping in an oncology population.
Injury, repair, inflammation and metaplasia in the stomach

The development of intestinal‐type gastric cancer is preceded by the emergence of metaplastic cell lineages in the gastric mucosa. In particular, intestinal metaplasia and spasmolytic polypeptide‐expressing metaplasia (SPEM) have been associated with the pathological progression to intestinal‐type gastric cancer. The development of SPEM represents a physiological response to damage that recruits reparative cells to sites of mucosal injury. Metaplastic cell lineages are characterized by mucus secretion, adding a protective barrier to the epithelium. Increasing evidence indicates that the influence of alarmins and cytokines is required to initiate the process of metaplasia development. In particular, IL‐33 derived from epithelial cells stimulates IL‐13 production by specialized innate immune cells to induce chief cell transdifferentiation into SPEM following the loss of parietal cells from the corpus of the stomach. While SPEM represents a physiological healing response to acute injury, persistent injury and chronic inflammation can perpetuate a recurring pattern of reprogramming and metaplasia that is a risk factor for gastric cancer development. The transdifferentiation of zymogen secreting cells into mucous cell metaplasia may represent both a general repair mechanism in response to mucosal injury in many epithelia as well as a common pre‐neoplastic pathway associated with chronic injury and inflammation.
The More Secure the Better?A Study of Information Security Readiness

Purpose – This paper seeks to investigate which factors influence user attitudes toward different levels of security measures for protecting data of differing importance. The paper also examines user characteristics including IT proﬁciency and risk propensity, which give rise to individual differences in such attitudes.Design/methodology/approach – To capture user attitudes toward a security measure, a construct called “information security readiness” (ISR) and its corresponding measurement items were developed. Observations were collected from a laboratory experiment based on a 2×3 factorial design, with data criticality and security level as the treatment variables. The participants were undergraduate students of a major American university. The moderating effect of data criticality on the relationship between security level and ISR was tested with multi‐group structural equation modeling. In addition to the treatment variables, IT proﬁciency and risk propensity were included as covariates in the analys.
Uteroplacental insufficiency temporally exacerbates salt‐induced hypertension associated with a reduced natriuretic response in male rat offspring

Low weight at birth increases the risk of developing chronic diseases in adulthood A diet that is high in salt is known to elevate blood pressure, which is a major risk factor for cardiovascular and kidney diseases The present study demonstrates that growth restricted male rats have a heightened sensitivity to high dietary salt, in the context of raised systolic blood pressure, reduced urinary sodium excretion and stiffer mesenteric resistance vessels Other salt‐induced effects, such as kidney hyperfiltration, albuminuria and glomerular damage, were not exacerbated by being born small The present study demonstrates that male offspring born small have an increased cardiovascular susceptibility to high dietary salt, such that that minimizing salt intake is probably of particular benefit to this at‐risk population
Fibre sub‐type specific conduction reveals metabolic function in mouse sciatic nerve

We have developed an improved method that enables simultaneous recording of stimulus evoked compound action potentials from large myelinated A fibres and small unmyelinated C fibres in mouse sciatic nerves. Investigations into the ability of fructose to support conduction in sciatic nerve revealed a novel glia‐to‐axon metabolic pathway in which fructose is converted in Schwann cells to lactate for subsequent shuttling to A fibres. The C fibres most likely directly take up and metabolise fructose. These differences are indicative of fibre sub‐type specific metabolic profiles. These results demonstrate that the physiological insights provided by the method can be applied to investigations of peripheral nerve, with a view to understanding the metabolic disruptions that underlie diabetic neuropathy.
Left Brain Asymmetry of the Planum Temporale in a Nonhominid Primate: Redefining the Origin of Brain Specialization for Language

The planum temporale (PT) is a critical region of the language functional network in the human brain showing a striking size asymmetry toward the left hemisphere. Historically considered as a structural landmark of the left-brain specialization for language, a similar anatomical bias has been described in great apes but never in monkeys-indicating that this brain landmark might be unique to Hominidae evolution. In the present in vivo magnetic resonance imaging study, we show clearly for the first time in a nonhominid primate species, an Old World monkey, a left size predominance of the PT among 96 olive baboons (Papio anubis), using manual delineation of this region in each individual hemisphere. This asymmetric distribution was quasi-identical to that found originally in humans. Such a finding questions the relationship between PT asymmetry and the emergence of language, indicating that the origin of this cerebral specialization could be much older than previously thought, dating back, not to the Hominidae, but rather to the Catarrhini evolution at the common ancestor of humans, great apes and Old World monkeys, 30-40 million years ago.
The Subpial Granular Layer and Transient Versus Persisting Cajal-Retzius Neurons of the Fetal Human Cortex

Neurons of the subpial granular layer (SGL) in the human marginal zone (MZ) migrate tangentially from the periolfactory subventricular zone all over the neocortex. After an immature stage, from 14 to 18 gestational weeks (GW), the SGL attains maximum prominence around midgestation. At 20-25 GW, a transient miniature cell type in the MZ expresses glutamate decarboxylase (GAD) and calretinin, and extends a varicose plexus surrounding somata of large transient Cajal-Retzius neurons (tCRN), potentially modulating their activity. The compact Reelin+ horizontal axon plexus of tCRN forms a transient interface between cortical plate and MZ; it may serve as a migration substrate for cortical interneurons, and attracting NPY+ fibers from the subplate. Around 30 GW, after the disappearance of SGL and tCRN, a population of persisting Cajal-Retzius neurons (pCRN) appears and remains into adult life. pCRNs express Reelin, Tbr1, calretinin, nitric oxide synthase, and the cytokine receptor CXCR4. They are characterized by subpial location, closeness to blood vessels, and aggregation in the walls of developing sulci. Unlike tCRNs, pCRNs do not develop a compact axon plexus in the lower MZ. Occasional mitoses in the midgestation SGL suggest that CRN progenitor cells may give rise to late-appearing pCRNs populating the definitive molecular layer.
Manufacturing Strategies for Time Based Competitive Advantages

Purpose – The main purpose of this paper is to investigate the current manufacturing strategies and practices of bus manufacturers in China, and to propose a framework of manufacturing strategies for time‐based competitive advantages.Design/methodology/approach – The conceptual research framework is devised from a review of the literature, and case studies are used to investigate the manufacturing strategies and practices in place in the case companies. Data are collected through semi‐structured interviews and secondary documentation.Findings – The results show that, with over‐capacity in the Chinese bus manufacturing industry, success is no longer determined by high productivity or low price; a quick response to the customers' tailored demands is essential in a climate of fierce competition. The suggested best practices for time‐based competitive advantages comprise building technical centers and post‐doctoral research stations, applying modularity logic, adopting radio frequency identification (RFID), a.
Dual mode of junctional transmission at synapses between single primary afferent fibres and motoneurones in the amphibian

1. The isolated hemisected frog spinal cord has been used to examine the effects of changes in ionic composition of perfusing medium on the intracellularly recorded e.p.s.p.s produced in single motoneurones by direct stimulation of individual dorsal root fibres through a separate intracellular micro‐electrode.
Computing the Social Brain Connectome Across Systems and States

Social skills probably emerge from the interaction between different neural processing levels. However, social neuroscience is fragmented into highly specialized, rarely cross-referenced topics. The present study attempts a systematic reconciliation by deriving a social brain definition from neural activity meta-analyses on social-cognitive capacities. The social brain was characterized by meta-analytic connectivity modeling evaluating coactivation in task-focused brain states and physiological fluctuations evaluating correlations in task-free brain states. Network clustering proposed a functional segregation into (1) lower sensory, (2) limbic, (3) intermediate, and (4) high associative neural circuits that together mediate various social phenomena. Functional profiling suggested that no brain region or network is exclusively devoted to social processes. Finally, nodes of the putative mirror-neuron system were coherently cross-connected during tasks and more tightly coupled to embodied simulation systems rather than abstract emulation systems. These first steps may help reintegrate the specialized research agendas in the social and affective sciences.