Miracle-dz/UniFAR-FTUs huggingface dataset:
The Exposure of Phosphatidylserine Influences Procoagulant Activity in Retinal Vein Occlusion by Microparticles, Blood Cells, and Endothelium

The pathogenesis of hypercoagulability in retinal vein occlusion (RVO) is largely unknown. Whether the exposure of phosphatidylserine (PS) and microparticle (MPs) release will affect procoagulant activity (PCA) in RVO needs to be investigated. Objectives. To evaluate PS expression, circulating MPs, and the corresponding PCA in RVO patients. Twenty-five RVO patients were compared with 25 controls. PS-positive cells were detected by flow cytometry. Cell-specific MPs were measured by lactadherin for PS and relevant CD antibody. We explored PCA with coagulation time, purified coagulation complex assays, and fibrin production assays. In RVO, MPs from platelets, erythrocytes, leukocyte, and endothelial cells were increased and the exposure of PS was elevated significantly when compared with controls. In addition, we showed that circulating MPs in RVO patients were mostly derived from platelets, representing about 60–70% of all MPs, followed by erythrocytes and leukocytes. Moreover, PS exposure, ECs, and MPs in RVO lead to shortened clotting time with upregulation of FXa and thrombin formation obviously. Importantly, ECs treated with RVO serum which bounded FVa and FXa explicitly suggested the damage of retinal vein endothelial cells. Furthermore, lactadherin can inhibit the combination between PS and coagulation factors by approximately 70% and then exert an anticoagulant effect. In summary, circulating MPs and exposed PS from different cells may contribute to the increased PCA in patients with RVO. Lactadherin can be used for PS detection and an anticoagulant agent.
Serum Hepcidin Level as a Marker of Iron Status in Children with Cystic Fibrosis

Introduction Iron deficiency is common in patients with cystic fibrosis. Conventional iron status markers are often abnormal in patients with CF, reflecting inflammation and/or infection, rather than actual iron stores. The aim was to evaluate serum hepcidin levels against selected iron status markers, assuming that hepcidin may be a more sensitive indicator of iron management in patients with active inflammation, such as those with CF. Material and Methods 46 children with cystic fibrosis and 31 healthy controls were enrolled. Hepcidin concentration was evaluated, along with the following other blood assays: full blood count, Fe, ferritin, transferrin, TIBC, liver markers, and CRP. Results Higher ferritin and CRP levels as well as lower TIBC levels significantly predicted hepcidin levels in the study group, control group, and the entire sample. There was no significant difference in hepcidin levels between the patients and controls. Children with exacerbations had significantly higher hepcidin levels than those with stable disease. These findings support the serum hepcidin level as useful in assessing iron status in children with cystic fibrosis. It may also be useful in early detection and monitoring of treatment of exacerbations.
Acute Effects of Whole-Body Vibration on Inflammatory Markers in People with Chronic Obstructive Pulmonary Disease: A Pilot Study

Whole-body vibration (WBV) has gained prominence in the rehabilitation of individuals with chronic obstructive pulmonary disease (COPD) because it is a safe and low intensity exercise that promises beneficial effects on physical performance and quality of life. However, its effects on plasma cytokine levels in COPD are still unclear. The aim of the current study was to investigate the acute effects of WBV on inflammatory biomarkers in people with COPD. Twenty-six participants, COPD people (n=13) and healthy controls (n=13), were included. Both groups performed WBV at amplitude of 2 mm and frequency of vibration of 35 Hz, during six series of 30 seconds. They were assessed for lung function, body composition, 6-minute walking test (6MWT), handgrip strength test, plasma concentrations of interleukin (IL), IL-6, IL-8, and IL-10, and soluble tumor necrosis factor alpha (TNF-α) receptors (sTNFR-1 and sTNFR-2). People with COPD had moderate disease [forced expiratory volume in the first second (FEV1) = 58.1%], as well as a worse performance in the 6MWT. The plasma cytokine profile at rest showed that participants with COPD had higher levels of IL-8 and lower levels of IL-10. After one session of WBV, we found an increased plasma IL-10 level in the COPD group, with similar levels for healthy controls. One session of WBV modified the plasma IL-10 level. No effects were found on the other investigated cytokines.
A Comparative In Vivo Study on Three Treatment Approaches to Applying Topical Botulinum Toxin A for Crow's Feet

Objective To evaluate the efficacy and safety of three treatment approaches to applying Botulinum Toxin Type A (BoNTA) for crow's Feet. Methods Thirty female subjects with moderate-to-severe crow's feet were included in this comparative in vivo study. They were randomly divided into three groups, including the local intramuscular, intradermal microdroplet injection, and nanomicroneedle delivered with BoNTA therapy group. After one session, evaluations were done at the time points of weeks one, four, and twelve after the treatment. The assessments included subjective satisfaction, blinded clinical assessment, and the biophysical parameters (skin collagen content, elasticity, hydration, and sebum contents). Results For dynamic wrinkles, intramuscular injection and intradermal microdroplets injection were more effective than nanomicroneedles. For static wrinkles, nanomicroneedles and intradermal microdroplets injection were more effective. However, the intramuscular injection had no significant effect on static wrinkles. At one week and four weeks after the treatment, the skin elasticity, collagen content, and hydration of nanomicroneedle group and intradermal microdroplet group increased more significantly than those of the intramuscular injection group; at twelve weeks after the treatment, the skin elasticity, collagen content, and hydration of intradermal microdroplet group were higher than those of other two groups. However we observed no statistically significant difference in sebum content between the three groups before and after the treatment. Conclusion BoNTA delivered through nanomicroneedles and intradermal microdroplets injection can effectively treat crow's feet. This trial is registered with [2016]KY018-01, registered 16 Feb 2016.
Influence of Chronic Alcohol Use on Osteoblastic Differentiation of Bone Marrow Cells, Bone Properties, and Hepatic and Renal Morphology of Rats

Chronic alcohol exposure can affect the osteoblastic activity and the proliferation and differentiation of cells due to its toxic effect, which can affect negatively bone repair and bone microarchitecture. The aim of this study was to evaluate the effects of chronic use of 20% alcohol on rats regarding osteoblastic differentiation, extrinsic and intrinsic properties of the tibia, and hepatic and renal morphology. Wistar rats were divided into three groups (n = 9) in accordance with a 24-week diet. After euthanasia, kidneys, liver, and tibias were removed for analysis and femurs mesenchymal cells were collected. The results showed that chronic use of 20% alcohol influenced neither the alkaline phosphatase production nor total protein (p > 0.05) in rats, with similar formation of nodules in all groups (p > 0.05). However, significant changes in the liver and kidneys and adverse effects on the mechanical properties of the tibia were observed. According to the results, it can be concluded that the chronic use of alcohol for 24 weeks had no negative influence on the activity and differentiation of osteoblasts, but the mechanical properties of the tibia were impaired and the organs responsible for metabolism and excretion were also affected due to the consumption of alcohol.
New Insights Regarding the Potential Health Benefits of Isoflavones

Isoflavones are a class of plant secondary metabolites, with an estrogen‐like structure presenting a plethora of biological activities. The chapter discusses important facts about this class of phytoestrogens, from biosynthesis to the latest research about their health benefits. The following major points discussed are: biosynthesis, regulation, isolation, metabolism and bioavailability, isoflavones in diet and intake, and new insights regarding the therapeutic effect including cancer chemoprevention. The chapter ends with a mini review of own research of the anti‐inflammatory and chemopreventive activity of iso‐ flavonoid genistein alone and incorporated in modern pharmaceutical formulations. The chapter updates the interested researchers in the field with the latest progress regarding potential health benefits of isoflavones. MTT proliferation assay on three human breast cancer cell lines MCF7, MDA‐MB‐231 and T47D‐human breast adenocarcinoma cell lines. Tests were performed also for the antimicrobial and antifungal activity against the following strains: S. aureus , E. coli , P. aeruginosa , Salmonella enteritidis , B. subtilis , Bacillus cereus and Candida albicans employing the dilution method. Results made us to conclude that the PM are a bad in vitro carrier partner for genistein In vivo assays were also performed in order to test the chemopreventive effects of genistein against murine melanoma. During the research in our group, we have observed in a murine model of melanoma, obtained by subcutaneous injection of 0.1 ml of 1*10 5 B164A5 cells/mouse that, genistein after a period of 15 days at a dose of 15 mg/kg, body weight decreased tumor vol‐ ume and weigh with about 30% and reduced distance tumors. Noninvasive measurements using the Multiprobe Adapter System (MPA5) from Courage‐Khazaka, Germany, Mexameter ® MX that genistein the quantity of melanin and the degree of erythema directly cor‐ related with the number of days of treatment very well known, the link between cancer, we analyzed the effect of genistein in an animal model of ear alone and after incorporation in hydroxypropyl‐beta‐cyclodextrin randomly‐methylated‐beta‐cyclodextrin (RAMEB). Cyclodextrins are well known
Born-Jordan Pseudo-Differential Operators with Symbols in the Shubin Classes

We apply Shubin's theory of global symbol classes $\Gamma_{\rho}^{m}$ to the Born-Jordan pseudodifferential calculus we have previously developed. This approach has many conceptual advantages, and makes the relationship between the conflicting Born-Jordan and Weyl quantization methods much more limpid. We give, in particular, precise asymptotic expansions of symbols allowing to pass from Born-Jordan quantization to Weyl quantization, and vice-versa. In addition we state and prove some regularity and global hypoellipticity results.
Carbon footprint of geopolymeric mortar: Study of the contribution of the alkaline activating solution and assessment of an alternative route

CO2 emissions associated with geopolymeric mortar prepared using spent fluid catalytic cracking catalyst (FCC) were compared to those calculated for plain ordinary Portland cement (OPC) mortar. Commercial waterglass used for preparing the alkaline activating solution for geopolymeric mortar was the main contributing component related to CO2 emission. An alternative route for formulating alkaline activating solution in the preparation of the geopolymeric binder was proposed: refluxing of rice husk ash (RHA) in NaOH solution. Geopolymeric mortar using rice hull ash-derived waterglass led to reduced CO2 emission by 63% compared to the OPC mortar. The new alternative route led to a 50% reduction in CO2 emission compared to geopolymer prepared with commercial waterglass. Replacement of commercial waterglass by rice hull ash-derived waterglass in the preparation of the geopolymer did not cause a significant decrease in the mechanical strength of the mortar. CO2 intensity performance indicators (Ci) for geopolymeric mortars were lower than that found for OPC mortar, indicating that the new route for activating solution led to the lowest Ci value.
PARA-BLASCHKE ISOPARAMETRIC HYPERSURFACES IN THE UNIT SPHERE Sn+1(1) (II)

Let D = A + λB be the para-Blaschke tensor of the immersion x, where λ is a constant, A and B are the Blaschke tensor and the Möbius second fundamental form of x. A hypersurface x : M 7→ S(1) in the unit sphere S(1) without umbilical points is called a para-Blaschke isoparametric hypersurface if the Möbius form Φ vanishes identically and all of its para-Blaschke eigenvalues are constants. In [11], we classified the para-Blaschke isoparametric hypersurfaces with three distinct Blaschke eigenvalues, one of which is simple or with three distinct Möbius principal curvatures, one of which is simple. In this article, we continue to study the topic of para-Blaschke isoparametric hypersurfaces and obtain the classification of para-Blaschke isoparametric hypersurfaces with three distinct para-Blaschke eigenvalues, one of which is simple.
Evolution of Iron Kα Line Emission in the Black Hole Candidate GX 339–4

GX 339-4 was regularly monitored with the Rossi X-Ray Timing Explorer during a period (in 1999) when its X-ray flux decreased significantly (from 4.2 × 10-10 to 7.6 × 10-12 ergs cm-2 s-1 in the 3-20 keV band), as the source settled into the "off state. " Our spectral analysis revealed the presence of a prominent iron Kα line in the observed spectrum of the source for all observations. The line shows an interesting evolution: it is centered at ~6.4 keV when the measured flux is above 5 × 10-11 ergs cm-2 s-1 but is shifted to ~6.7 keV at lower fluxes. The equivalent width of the line appears to increase significantly toward lower fluxes, although it is likely to be sensitive to calibration uncertainties. While the fluorescent emission of neutral or mildly ionized iron atoms in the accretion disk can perhaps account for the 6.4 keV line, as is often invoked for black hole candidates, it seems difficult to understand the 6.7 keV line with this mechanism because the disk should be less ionized at lower fluxes (unless its density changes drastically). On the other hand, the 6.7 keV line might be due to a recombination cascade of hydrogen- or helium-like iron ions in an optically thin, highly ionized plasma. We discuss the results in the context of proposed accretion models.
Spatial separation of Afrotropical dung beetle guilds: a trade‐off between competitive superiority and energetic constraints (Coleoptera: Scarabaeidae)

In the forest-savanna mosaic of Cote d'Ivoire (Parc National de la Comoe), we studied the guild structure of dung beetle assemblages of fresh buffalo faeces (60 samples, 19 626 specimens) in three adjacent habitats: savanna parkland, gallery forest, grassland of the river valley. We found clear patterns at the guild level determined by the habitat type and time of day: in the savanna parkland during the day, telecoprids (rollers) and their kleptoparasites are dominant. At night, paracoprids (tunnelers) and endocoprids (dwellers) dominate the dung beetle assemblages. In the river valley during the day and the gallery forest all day and night, the abundance of dung beetles is very low and does not reach a competitive level. In the river valley at night, endocoprids are quite abundant. Abundances of kleptoparasites and their hosts are positively correlated. The telecoprids are the most competitively superior guild since they use the resource most rapidly, but their abundance is correlated with temperature of faeces and soil. This is probably because their mode of resource utilization is energetically costly, so they require higher temperatures in order to maximize their competitiveness. Their ecological tolerance is therefore narrow and they are only present in the savanna parkland during the day. The endocoprids are the least competitive guild, since they do not relocate the resource and so are not able to monopolize parts of it. However, their mode of resource utilization is less energetically costly. They seem to be more tolerant of temperature fluctuation and more able to cross barriers such as the gallery forest. Spatial separation of Afrotropical dung beetle guilds is likely to be due to a trade-off between competitive superiority and energetic constraints.
Use of Autologous Adipose- Derived Stromal Vascular Fraction to Treat Osteoarthritis of the Knee: A Feasibility and Safety Study

Autologous adipose-derived stromal vascular fraction (SVF) was used to treat ten osteoarthritic knees of grades II or III (K-L scale) under an IRB-approved protocol in a feasibility and safety study. The primary objective of this study was to determine if adipose-derived SVF can be safely used for intra-articular injection of the knee. The secondary objective of this study was to evaluate the feasibility of an intra-articular injection of adipose-derived SVF for pain relief in osteoarthritic knees.
Which is the Appropriate Frequency of TENS in Managing Knee Osteoarthritis: High or Low Frequency? Diz Osteoartriti Tedavisinde Hangi TENS Frekansi daha Uygundur: Yüksek veya Düşük Frekans?

1 Esra Erkol Inal1, Pinar Eroglu2, Serap Hizli Yucel2, Hikmet Orhan3 1 Department of Physical Medicine and Rehabilitation, Suleyman Demirel University, Faculty of Medicine, Isparta, 2 Department of Physical Medicine and Rehabilitation, Ankara Occupational Disease Hospital, Ankara, 3 Department of Biostatistics and Medical Informatics, Suleyman Demirel University, Faculty of Medicine, Isparta, Turkey TENS ve Diz Osteoartriti / TENS and Knee Osteoarthritis Which is the Appropriate Frequency of TENS in Managing Knee Osteoarthritis: High or Low Frequency?
Monitoring the Distribution, Use, and Regeneration of Natural Resources in Semi-arid Southwest Asia

We describe a variety of satellite-derived datasets and their application to understanding changes in the landscape of southwest Asia, including regional climatology, natural vegetation, and the expansion and intensification of agricultural production. We demonstrate the effectiveness of several remote sensing tools in gauging environmental change in this semi-arid region as well as offering insights into the appropriate analysis of remotely sensed datasets. INTRODUCTION Agricultural and pastoral production in the semi-arid regions of southwest Asia has expanded rapidly over recent decades to meet the subsistence needs of one of the world’s fastest growing populations and the demands of the international economy. This growth is constrained by great interannual variation in the amount and timing of rainfall, which restricts dependable farming to very limited areas. Development, nonetheless, has proceeded undeterred—defying climate through feats of hydrological engineering or betting against it by cultivating vast areas of agriculturally marginal land. These two processes, the intensification and extension of agricultural production, have been among the dominant forces shaping the modern environments of southwest Asia, but their spatial expression is complex. The many nations of this region differ widely in their climate and natural resources as well as in their development priorities, available capital, and access to technology. Everywhere, however, pressure on limited water, soil, and plant resources has increased, often nearing the point of exhaustion or international conflict. Growing concern about the natural resource base has led governments and independent groups across the region to initiate ambitious and costly conservation and management programs. Ultimately, the success of these efforts depends on the development of methods for efficient, quantitative measurement of the distribution, use, and regeneration of natural resources at a range of spatial scales. Multispectral satellite data and techniques of image analysis offer a potentially powerful tool for understanding problems in the climatology, environmental history, and natural resource management of southwest Asia. Satellite data have been collected over southwest Monitoring the Distribution, Use, and Regeneration of Natural Resources in Semi-arid Southwest Asia
Hypnotic susceptibility and holistic/emotional styles of thinking

It has been suggested that an everyday preference for holistic and emotional thought is related to the ability to enter hypnosis, although research addressing the idea has often yielded inconsistent results. This study correlated hypnotic susceptibility, as measured by the Harvard Group Scale (Shor and Orne, 1962), with three measures of a holistic/emotional thinking style: the experiential sub-scale of the Rational Versus Experiential Inventory (RVEI) (Epstein et al., 1995), the right hemisphere sub-scale of the Human Information Processing Survey (HIPS) (Taggart and Torrance, 1984) and the elaborative processing sub-scale of the Inventory of Learning Processes (ILP) (Schmeck et al., 1977). A social desirability measure was also included. Only the experiential scale of the RVEI and the social desirability scale showed significant positive correlations with susceptibility; a multiple regression analysis showed the RVEI scale to be the best predictor of susceptibility. The implications of these results for the analytic-holistic hypothesis in hypnosis are discussed. Copyright © 1998 British Society of Experimental and Clinical Hypnosis
Mapping Lorey’s height over Hyrcanian forests of Iran using synergy of ICESat/GLAS and optical images

ABSTRACT Lorey’s height, representative of mean height in uneven-aged forest stands, is a valuable parameter for forest ecosystem management. While in situ measures provide the most precise information, remote-sensing techniques may provide less expensive but denser and more operational alternative of Lorey’s height estimation over highly mountainous areas. This research aims first to evaluate the performances of two nonparametric data mining methods, random forest (RF) and artificial neural network (ANN), for estimation of Lorey’s height using ice, cloud and land elevation satellite/geoscience laser altimeter system (ICESat/GLAS) in Hyrcanian forests of Iran and then to provide Lorey’s height map using a synergy of ICESat/GLAS and optical images (TM and SPOT). RF and ANN GLAS height models were developed using waveform deterministic metrics, principal components (PCs) from principal component analysis (PCA) and terrain index (TI) extracted from a digital elevation model (DEM). The best result was obtained using an ANN combining first three PCs of PCA and waveform extent ʺWextʺ (RMSE = 3.4 m, RMSE% = 12.4). In order to map Lorey’s height, GLAS-estimated heights were regressed against indices derived from optical images and also topographic information. The best model (RF regression with RMSE = 5.5 m and = 0.59) was applied on the entire study area, and a wall-to-wall height map was generated. This map showed relatively good compatibility with in situ measurements collected in part of the study area.
Pilot scale enzymatic deinking of mixed office wastepaper and old newspaper

The performance of a newly developed pilot scale continuous enzymatic deinking system has been evaluated using a mixture of cellulase and xylanase enzymes in the deinking of mixed office wastepaper (MOW) and old newspaper (ONP). Optimizations of the enzymatic deinking processes were carried out, and the optimum conditions obtained for MOW and ONP were different. The highest brightness obtained from enzymatic deinking of MOW and ONP under their respective optimum conditions were about 83.6% and 41.9%, respectively. The deinking efficiency of 6.0% and 6.3% were obtained by enzymatic deinking process using MOW and ONP, respectively. On the other hand, the deinking efficiency of 2.9% and 3.5% were obtained by a chemical deinking process using MOW and ONP, respectively. The findings obtained from present work indicated that enzymes have potential to be used in deinking of MOW, which is difficult to deink by conventional chemical deinking methods.