Miracle-dz/UniFAR-FTUs huggingface dataset:
VIOLENCE À L'ÉCOLE, VIOLENCE AU TRAVAIL

Dans l'enquete nationale Qualite de vie des enseignants, 17 % des enseignants declaraient avoir ete victimes de comportements hostiles de maniere repetee (« violence psychologique au travail ») au cours des deux premiers trimestres de l'annee scolaire 2012-2013, et 40 % d'en avoir ete temoins. La violence « scolaire » impliquant un eleve etait surtout presente dans le secondaire, alors que la violence dans le premier degre impliquait plutot un parent. La violence « interne » inherente au monde professionnel s'ajoutait a tous les niveaux d'enseignement : relations conflictuelles avec les collegues et tension avec la hierarchie. Les enseignantes etaient plus souvent victimes de violence psychologique au travail que leurs homologues masculins. Les enseignants du superieur etaient moins concernes ainsi que les professeurs du prive. La probabilite d'etre temoin de violence n'etait pas differente chez les hommes et les femmes, mais elle etait plus elevee dans le second degre, au college et dans les lycees professionnels notamment. Dans les modeles multivaries, les autres facteurs professionnels significativement associes a un risque plus eleve d'exposition a la violence au sens large (en etre temoin et/ou victime) etaient le mauvais etat des locaux, l'origine sociale defavorisee des eleves et la forte urbanisation de la zone d'implantation de l'etablissement. L'exposition a la violence, qu'il s'agisse d'avoir ete temoin uniquement ou victime directe, etait associee a de moins bons indicateurs de bien-etre professionnel, mais aussi de bien-etre global, appuyant l'importance de la lutte contre la violence a l'ecole sous toutes ses formes.
Exercise training improves ageing-induced decrease in eNOS expression of the aorta.

AIMS Ageing impairs endothelial function such as the regulation of vascular tone. The release of nitric oxide (NO), which has a potent vasodilator effect and antiatherosclerotic property, is decreased in the aorta of aged rats. Exercise training, however, has been reported to increase the expression of endothelial NO synthase (eNOS) in the aorta of young rats. In aged rats, it is not known whether the expression of eNOS is altered by exercise training. We hypothesized that exercise training would improve the ageing-induced decrease in eNOS expression in vessels, and examined the messenger RNA (mRNA) and protein expression of eNOS in the aorta of sedentary-young rats (sedentary-young group; 4 months old), sedentary-aged rats (sedentary-aged group; 23 months old), and swim-trained aged rats (training-aged group; 23 months old, swimming training for 8 weeks, 5 days week(-1), 90 min day(-1)). RESULTS Body weight was significantly lower, and citrate synthase activity in the epitrochlearis muscle was significantly higher in the training-aged group compared with the sedentary-aged group. The mRNA expression of eNOS in the aorta was significantly higher in the training-aged group than in the sedentary-aged group, while it was significantly lower in both the sedentary-aged and training-aged groups than in the sedentary-young group. The expression of eNOS protein in the aorta was also significantly higher in the training-aged group than in the sedentary-aged group, while it was also significantly lower in the sedentary-aged group, but not in the training-aged group, than in the sedentary-young group. CONCLUSION The present results revealed that the production of eNOS in the aorta decreases with ageing, and that the decreased production is increased by exercise training in aged rats, which may produce beneficial effects on the impaired cardiovascular system caused by ageing.
Improvement in sperm quality and function with French maritime pine tree bark extract.

OBJECTIVE To determine the effects of Pycnogenol (French maritime pine tree bark extract) on sperm parameters and function in subfertile men. STUDY DESIGN Prospective, nonrandomized, clinical study in a private infertility practice. Nineteen subfertile men were given 200 mg Pycnogenol daily orally for 90 days. Semen samples were analyzed before and after treatment for sperm count, motility score and strict morphology before and after capacitation, and mannose receptor binding. RESULTS The mean sperm morphology following Ham's F-10 capacitation increased by 38% following Pycnogenol treatment, and the mannose receptor binding assay scores improved by 19%. CONCLUSION Pycnogenol therapy resulted in improved capacitated sperm morphology and mannose receptor binding. The increase in morphologically and functionally normal sperm may allow couples diagnosed with teratozoospermia to forgo in vitro fertilization and either experience improved natural fertility or undergo less invasive and less expensive fertility-promoting procedures, such as intrauterine insemination.
Cooperative control of nonlinear multi-agent systems with only relative position measurements

In this paper, we study the distributed cooperative control of second-order multi-agent systems with intrinsic nonlinear dynamics under an undirected graph that characterizes the interaction among the followers or agents. By introducing a distributed filter for each follower or agent, the proposed control algorithms use only relative position measurements. Both the coordination tracking problem with a dynamic leader and the leaderless consensus problem are considered. In the special case when the intrinsic nonlinear dynamics are zero, i.e., for multi-agent systems with second-order integrators, we further derive results for the leaderless consensus problem under a directed graph. We present a necessary and sufficient condition such that the systems achieve consensus using only relative position measurements.
Review of E-Learning Environment at the Kwame Nkrumah University of Science and Technology, Ghana

An article by Tawiah, Richard; Bruce Lamptey, Richard; Okyere, Gabriel Asare; Oduro, William; and Thompson, Michael Oko, "Review of ELearning Environment at the Kwame Nkrumah University of Science and Technology, Ghana" (2019). Library Philosophy and Practice (e-journal). 2337; https://digitalcommons.unl. edu/libphilprac/2337
The role of molecular staging in malignant melanoma.

AIMS To review the role of tyrosinase RT-PCR in the detection of clinically occult metastatic disease, both within the regional lymph nodes and peripheral blood of patients with malignant melanoma. Secondly, to assess whether the detection of such minimal disease has clinical implications for patients with melanoma. METHODS A review of the literature was undertaken by searching the MEDLINE database for the period 1966-2002 without any language restrictions. Keywords included 'Molecular staging of melanoma', 'Reverse transcription polymerase chain reaction', 'Malignant melanoma' and 'Tyrosinase'. CONCLUSIONS Detection of tyrosinase RT-PCR positive cells within the peripheral blood correlates with the clinical stage of malignant melanoma, the primary tumour thickness and other known prognostic indicators. Positive tyrosinase RT-PCR is associated with a reduction of disease-free survival and overall survival. Current studies demonstrate a higher rate of recurrence in RT-PCR positive patients with clinical stage II and III disease. Implications of a positive result within the regional lymph nodes are less well defined. A significant correlation has been demonstrated between positive results and increasing primary melanoma thickness. However, a large number of false-positive results have been demonstrated, due to benign naevi and schwann cells, which may hamper any statistically significant conclusions being reached.
Viral RNA Is Required for the Association of APOBEC3G with Human Immunodeficiency Virus Type 1 Nucleoprotein Complexes

ABSTRACT APOBEC3G (APO3G) is a host cytidine deaminase that is incorporated into human immunodeficiency virus type 1 (HIV-1) particles. We report here that viral RNA promotes stable association of APO3G with HIV-1 nucleoprotein complexes (NPC). A target sequence located within the 5′-untranslated region of the HIV-1 RNA was identified to be necessary and sufficient for efficient APO3G packaging. Fine mapping revealed a sequence normally involved in viral genomic RNA dimerization and Gag binding to be important for APO3G packaging and association with viral NPC. Our data suggest that packaging of APO3G into HIV-1 NPC is enhanced by viral RNA.
Pharmacokinetics and metabolism of a sulphamide NK2 antagonist in rat, dog and human

1. UK-224,671 is a sulphamide-containing NK2 antagonist with moderate lipophilicity and basicity. 2. The physicochemical properties of UK-224,671 are reflected in its pharmacokinetics following intravenous (i.v.) administration. The compound partitioned extensively into red blood cells in all species examined and the blood clearance was moderate to low with respect to liver blood flow and distribution into tissues was extensive. 3. UK-224,671 exhibited species differences in oral bioavailability. In dog, the compound exhibited moderate bioavailability (55%), whereas in rat and man oral bioavailability was < 10%. 4. In rat and dog, the major excreted form after i.v. administration was unchanged UK224,671 in both urine and faeces. In addition, of three metabolites observed, the most abundant was the N-descyclopropylmethyl (UK-280,045). 5. The profile of radioactivity in rat following oral administration of [14C]-UK-224,671 was not consistent with a 10% absorbed compound with 40% of the dose present as metabolites. This suggests that the low bioavailability of UK-224,671 in rat is due to a combination of moderate intestinal permeability and extensive first-pass metabolism by the gut and does not result from poor gastrointestinal absorption per se.
Skeletal histology of the dermal armor of Placodontia: the occurrence of ‘postcranial fibro‐cartilaginous bone’ and its developmental implications

Placodontia (Reptilia: Sauropterygia) is a group of enigmatic armored marine reptiles restricted to the Triassic time period. Only a single row of osteoderms dorsal to the spine is present in the basal placodontoid Placodus gigas, whereas derived cyamodontoids superficially resemble turtles in enclosing their body in an armor shell. Despite the extensive occurrence of the dermal armor in the derived cyamodontoid group, little research has focused on its bone histology and development. Here, I present an overview of the bone microstructures that reveals the unique presence of cartilaginous tissue in the postcranial armor plates. Placodont armor plates stand in contrast to osteoderms of other tetrapods that develop intramembraneously or through metaplastic ossification without cartilaginous preformation. The different developmental pathways leading to this ‘postcranial fibro‐cartilaginous bone’ tissue found in placodont plates compared to the dermal bone tissues of most other tetrapod osteoderms indicate the non‐homology of these structures. A resulting morphogenetic model of histogenesis is given to exemplify how the derived armor morphologies (i.e. spiked, flat polygonal and hexagonal, and rhomboidal shapes) together with the peculiar bone histologies could have developed through differential growth. In accordance with the pachyostotic limb bones of placodonts, the presence of the compact ‘postcranial fibro‐cartilaginous bone’ is interpreted as an osteosclerotic trend in the armor plates which aids in buoyancy control and affects maneuverability and swimming speed.
Heart Disease Classification Using Neural Network and Feature Selection

In this study, we introduces a classification approach using Multi-Layer Perceptron (MLP)with Back-Propagation learning algorithm and a feature selection algorithm along with biomedical test values to diagnose heart disease. Clinical diagnosis is done mostly by doctor's expertise and experience. But still cases are reported of wrong diagnosis and treatment. Patients are asked to take number of tests for diagnosis. In many cases, not all the tests contribute towards effective diagnosis of a disease. Our work is to classify the presence of heart disease with reduced number of attributes. Original, 13 attributes are involved in classify the heart disease. We use Information Gain to determine the attributes which reduces the number of attributes which is need to be taken from patients. The Artificial neural networks is used to classify the diagnosis of patients. Thirteen attributes are reduced to 8 attributes. The accuracy differs between 13 features and 8 features in training data set is 1.1% and in the validation data set is 0.82%.
Leistungs- und Qualitätseigenschaften jeweils zweier Herkünfte des Seesaiblings (Salvelinus alpinus) und des Bachsaiblings (Salvelinus fontinalis) sowie ihrer Kreuzungen

In zwei Durchgangen wurden Elterntiere jeweils zweier Herkunfte des Seesaiblings (Salvelinus alpinus) und des Bachsaiblings (Salvelinus fontinalis) gezielt miteinander gepaart. Neben Nachkommen in Reinzucht wurden reziproke Kreuzungen zum Elsasser Saibling durchgefuhrt, d. h. Bachsaiblingsrogner wurden mit Seesaiblingsmilchnern und Seesaiblingsrogner mit Bachsaiblingsmilchnern gekreuzt. In einigen Merkmalen (spate Geschlechtsreife, hohe Filetausbeute und hoher Fettgehalt im Filet) schnitten reine Nachkommen von Seesaiblingen besser ab. Hinsichtlich Wachstum, Futterverwertung, Filetfarbung, sensorische Qualitat und Fischgesundheit waren die reinerbigen Nachkommen von Bachsaiblingen im Vorteil. Elsasser Saiblinge zeigten bezuglich der meisten Merkmale durchschnittliche Werte. In Summation aller Ergebnisse wird unter den gegebenen Bedingungen die Produktion reiner Bachsaiblinge empfohlen.
THE EFFECTS OF CUTTING INTERVALS AND SEEDING RATES ON FORAGE YIELD AND QUALITY OF ALFALFA

Understanding the effects of seeding rate and cutting intervals on dry matter yield and nutritive value may help to optimize of alfalfa production. The objective of this study was to investigate the optimum cutting interval and seeding rate of two cultivars of alfalfa (cv. Alsancak and cv. Nimet). Field experiments were carried out for 3 years in Mediterranean ecological conditions. The treatments were comprised of three cutting programs at 20, 30 and 40 days interval and two seeding rates (15 and 30 kg ha-1). The experiment was designed a split–split plot in a randomized complete block with 3 repetitions. The main plots were cutting intervals, sub-plots were seeding rates and sub –subplots were assigned as alfalfa cultivars. The results of the research showed that all properties inspected were significantly affected from the cutting intervals, the effect of the seeding rate and the cultivars were found to be not significant (except fresh forage yield). While the extended cutting intervals increased the forage yield, it reduced the forage quality. In terms of satisfactory forage yield and quality for similar ecological conditions, 30 days cutting interval and 15 kg ha-1 seeding rate have been advisable.
ACCUMULATION OF HEAVY METALS BY LETTUCE (LACTUCA SATIVA L.) IRRIGATED WITH DIFFERENT LEVELS OF WASTEWATER OF QUETTA CITY

Heavy metal contamination of soils resulting from irrigation by wastewater is causing major concern due to the potential health risk involved. This study was therefore designed to investigate the heavy metal ions viz., Cu 2+ , Fe 2+ concentrations by lettuce (Lactuca sativa L.) grown in pots. This leafy vegetable was irrigated with 5 different concentrations of wastewater collected from 3 different localities viz., Chiltan town, Chiltan Ghee Mill (oil industry) and Zarghoon town of Quetta city. Tap water was used as background water. Plant samples were analyzed for their heavy metal contents using Atomic Absorption Spectroscopy (AAS). Results showed that localities, treatments and their interactions (except Cu 2+ & Pb 2+ ) generally exhibited highly significant (P≤0.01) influence on the accumulation of heavy metals. The maximum values of 9.71; 509.06; 32.47; 94.38; 8.58; 5.05 and 7.45 mg kg -1 for Cu 2+ , total Fe 2+ , Mn 2+ , Zn 2+ , Ni 2+ ,Pb 2+ , and Cd 2+ respectively, were generally obtained in highest concentration of effluents. While maximum values of 9.02; 4.47 and 7.90 mg kg -1 of Cu 2+ , Ni 2+ and Cd 2+ were obtained for Chiltan ghee mill effluents. However, maximum values i.e., 435.96 and 80.47 mg kg -1 of total Fe and Zn 2+ were recorded for Chiltan town. The highest values of 30.09 and 6.32 mg kg -1 for Mn 2+ and Pb 2+ were noted in Zarghoon town, respectively. On the basis of grand mean values,the magnitude of heavy metals detected for various metals is in order: Fe > Zn >Mn> Cu >Pb> Cd > Ni. Results further demonstrated that the total concentrations of Cu 2+ , Fe 2+ , Mn 2+ , Zn 2+ and Ni 2+ are within the recommended international standards set by WHO/FAO, but could be reached to toxic level either by the consecutive use of effluents or by increased dietary pattern of the consumers. Whereas, the amount of Pb 2+ and Cd 2+ are at par than the international maximum permissible limits. This study highlights the potential health risks associated with the cultivation and consumption of leafy vegetables on wastewater- contaminated soils. Wastewater used for irrigation around the peri-urban area of Quetta is highly polluted especially in term 2+ & Cd 2+ metals. Therefore, domestic and industrial waste of the city should be properly disposed and or recycled so as to avoid the present/ future health risks.
Detection of BRAF mutation in thyroid papillary carcinomas by mutant allele-specific PCR amplification (MASA).

OBJECTIVE The somatic point mutation in the BRAF gene, which results in a valine-to-glutamate substitution at residue 600 (BRAF(V600E)), is an ideal hallmark of papillary thyroid carcinoma (PTC). However, its prevalence is varyingly reported in different studies, and its expression in the follicular variant PTC is controversial, reducing its potential usefulness as diagnostic marker. DESIGN AND METHODS We developed an assay based on mutant allele-specific PCR amplification (MASA) to detect BRAF mutation. We compared the sensitivity of MASA, single-strand conformation polymorphism (SSCP) and direct DNA sequencing of PCR products. Then, we used MASA 78 to analyze 78 archival thyroid tissues, including normal samples, follicular adenomas, follicular carcinomas and PTC. RESULTS The MASA assay proved to be a more sensitive method than SSCP and DNA sequencing of PCR products. BRAF mutation was found by MASA in 19/43 (44.2%) of PTC, including 14/31 (45.2%) classic forms and 5/12 (41.7%) follicular variants. No mutations of BRAF were detected in the normal thyroid tissues, nor in follicular adenomas or follicular carcinomas. No correlation was found between BRAF mutation and clinicopathologic features nor with recurrence during a postoperative follow-up period of 4-11 years. BRAF(V600E) significantly correlated with absence of node metastasis. CONCLUSIONS BRAF(V600E) is present in PTC, both in the classic form and in follicular variant with similar prevalence. No correlation was found between BRAF mutation and aggressive clinical behavior. MASA-PCR proved to be a specific, sensitive and reliable method to detect BRAF T1799A in DNA extracted from different sources, including cytologic samples obtained either fresh or from archival glass slides. We propose this method as a useful tool to improve accuracy of preoperative diagnosis identifying PTC from biopsies with indeterminate cytologic findings.
The amount of spermatic cord rotation magnifies the time-related orchidectomy risk in Intravaginal testicular torsion

Abstract Purpose To investigate the roles of age, testicular rotation and time in the surgical outcome of intravaginal testicular torsion (iTT). Patients and Methods We retrieved the records of all iTT patients treated in our unit from January 2012 to January 2014. Explanatory variables were: age (years); presentation delay (PrD, time between symptoms and hospitalization); surgical delay (SurgD, time between hospitalization and surgery) and testicular rotation (rotation), with surgical outcome (orchidopexy, orchidectomy) as response variable. Differences in PrD, SurgD, age and rotation by surgical outcome were evaluated non-parametrically. Step-down logistic regression included age, PrD, SurgD and rotation as predictors. Statistical significance and confidence intervals (CI) were set at p<0.05 and 0.95. Odds ratios (OR) were computed from the model's coefficients. Results Complete variable information was available for 117 patients, and most (61, 52.1%) underwent orchidectomy. Ages were similar between orchidectomy and orchidopexy patients (median 15.8 vs. 16.0 years, p=0.78). In contrast, PrD (85.0 vs. 8.4 hours, p<0.001), SurgD (3.0 vs. 16.0 hours, p<0.001) were different between orchidectomy and orchidopexy patients. SurgD was similar with PrD<24 hours (4.0 vs. 2.8, p=0.1). Orchidectomy patients had greater rotation (3.0π vs. 2.0π radians, p<0.001). Logistic regression revealed that PrD (OR 0.94; 0.92–0.97; p<0.001) and rotation (OR 0.43; 0.27–0.70; p<0.001) were inversely associated with orchidopexy. Conclusion Testicular rotation exerts a multiplicative effect on PrD, so time should not be regarded as the sole predictor of surgical outcome in iTT.
Experimental analysis of Helicobacter pylori transcriptional terminators suggests this microbe uses both intrinsic and factor‐dependent termination

In this study, we report experimental analysis of transcriptional terminators in the human pathogen Helicobacter pylori. Previous bioinformatics approaches came to differing conclusions regarding transcriptional termination in this bacterium. We used a reporter construct, the tnpR‐encoded resolvase, to assess terminators. In our first experiments, we found that a subset of previously predicted intrinsic terminators for H. pylori are functional. In our second experiments, we used an unbiased screen to identify putative terminators and then characterized 18 of these. We found that these putative terminators overlap genomic regions that are either intergenic or intragenic. Using reverse transcription PCR, we showed that an intergenic terminator and an intragenic antisense terminator function at their endogenous loci. Additionally, we found that putative terminators contain features of both intrinsic and Rho‐dependent termination, but that intrinsic terminators define the majority. We were unable to delete rho, however, in H. pylori, suggesting that it is essential and likely important. Finally, we carried out a mutational analysis of one of our randomly identified terminators that has both intrinsic and Rho‐dependent features, and found that they are both functional. In conclusion, we found that H. pylori possesses numerous Rho‐dependent and intrinsic terminators including some found in intragenic regions.