Miracle-dz/UniFAR-FTUs huggingface dataset:
Evidence based design of heuristics : usability and computer assisted assessment

The research reported here examines the usability of Computer Assisted Assessment(CAA) and the development of domain specific heuristics. CAA is being adopted within educational institutions and the pedagogical implications are widely investigated, but little research has been conducted into the usability of CAA applications. The thesis is: severe usability problems exist in GAA applications causing unacceptable consequences, and that using an evidence based design approach GAA heuristics can be devised The thesis reports a series of evaluations that show severe usability problems do occur in three CAA applications. The process of creating domain specific heuristics is analysed, critiqued and a novel evidence based design approach for the design of domain specific heuristics is proposed. Gathering evidence from evaluations and the literature, a set of heuristics for CAA are presented. There are four main contributions to knowledge in the thesis: the heuristics; the corpus of usability problems; the Damage Index for prioritising usability problems from multiple evaluations and the evidence based design approach to synthesise heuristics. The focus of the research evolves with the first objective being to determine If severe usability problems exist that can cause users d? ffIculties and dissatisfaction with unacceptable consequences whitct using existing commercial CAA software applications? Using a survey methodology, students' report a level of satisfaction but due to low inter-group consistency surveys are judged to be ineffective at eliciting usability problems. Alternative methods are analysed and the heuristic evaluation method is judged to be suitable. A study is designed to evaluate Nielsen's heuristic set within the CAA domain and they are deemed to be ineffective based on the formula proposed by Hanson et al. (2003). Domain specific heuristics are therefore necessary and further studies are designed to build a corpus of usability problems to facilitate the evidence based design approach to synthesise a set of heuristics, in order to aggregate the corpus and prioritise the severity of the problems a Damage Index formula is devised. The work concludes with a discussion of the heuristic design methodology and potential for future work; this includes the application of the CAA heuristics and applying the heuristic design methodology to other specific domains.
Acceleration of the onset of collagen-induced arthritis by a deficiency of platelet endothelial cell adhesion molecule 1.

OBJECTIVE Platelet endothelial cell adhesion molecule 1 (PECAM-1; CD31) is a member of the immunoglobulin superfamily that is expressed in platelets, leukocytes, and endothelial cells. PECAM-1 has been shown to play a role in transendothelial migration of leukocytes and contains immunoreceptor tyrosine-based inhibitory motifs in its cytoplasmic tail and inhibits cellular responses. We examined the role of PECAM-1 in the development of collagen-induced arthritis (CIA). METHODS CIA was induced in PECAM-1-deficient DBA/1 mice. The incidence of arthritis and the arthritis index were examined. Anti-type II collagen (anti-CII) antibody levels and interferon-gamma (IFNgamma) production by lymph node cells and spleen cells were determined. Lymphocytes from arthritic PECAM-1-deficient and wild-type mice were labeled with dye, transferred to arthritic PECAM-1(+/-) mice, and cell migration to inflamed joints was examined. RESULTS PECAM-1-deficient mice showed accelerated onset of arthritis and increased severity only during the early phase. Anti-CII antibody levels were also increased during the early phase. IFNgamma production by lymph node cells and spleen cells from PECAM-1-deficient mice in response to CII was higher than that in wild-type mice. Lymphocytes from arthritic PECAM-1-deficient mice showed accelerated migration to inflamed joints, but not lymph nodes or spleen. The development of anti-CII antibody-induced arthritis was similar in PECAM-1-deficient and wild-type mice. CONCLUSION These results indicate that PECAM-1 negatively regulates humoral and cell-mediated immune responses and lymphocyte migration into joints and, consequently, the development of CIA. In addition, the role of PECAM-1 in the transendothelial migration of leukocytes appears to be redundant in this model.
Near acoustic field of the finite rigid cone

The canonical problem of diffraction of the plane acoustic wave from the finite hollow rigid cone in the case of axial incidence is solved. The diffraction problem is formulated as a Neumann boundary value problem for the Helmholtz equation. The diffracted field is sought in the terms of eigenfunctions of the Helmholtz equation taking into account the radiation condition and the edge condition. Making use of the mode matching technique and the orthogonality properties of the Legendre functions the pertinent problem is reduced to infinite system of linear algebraic equations (ISLAE). Analytical regularization procedure is used to effect the analytical inversion of a singular part of the diffraction operator and to reduce the initial problem to ISLAE of the second kind. The numerical solution of ISLAE relies on the reduction method and it accuracy depends on number of truncation. The validity of obtained results is confirmed by it comparison with those known for a circular rigid disc.
Stress and coping in Japanese children and adolescents

Abstract Japanese children and adolescents (n=580) provided self-reports of stressor intensity, coping efforts, and adjustment. A new measure of Japanese adolescent coping was created, and psychometric analyses confirmed a reliable four-factor structure. Mean group difference analyses showed that girls reported higher levels of self-image and peer relations stress, and reported using isolation and problem-solving coping more and externalising coping less than males. Younger adolescents (5th/8th grades) reported higher stress in the domains of school, peer relations, and family relations, whereas older adolescents (10th grade) reported higher self-image problems. Statistical moderation was used to examine how youth negotiated the stress process. Females were found to be more responsive to appearance, family, and peer difficulties. Affiliation coping by females operated as a buffer between appearance anxiety and dissatisfaction with appearance. Externalizing coping was not associated with peer relations satisfaction for males, but it was negatively associated for females.
A Novel Phosphatidylcholine-hydrolyzing Phospholipase C Induced by Phosphate Starvation in Arabidopsis*

During phosphate starvation, it is known that phospholipids are degraded, and conversely, a nonphosphorus galactolipid digalactosyldiacylglycerol accumulates in the root plasma membrane of plants. We report a novel phospholipase C that hydrolyzes phosphatidylcholine and is greatly induced in response to phosphate deprivation in Arabidopsis. Since phosphatidylcholine-hydrolyzing activity by phospholipase C was highly up-regulated in phosphate-deprived plants, gene expression of some phospholipase C was expected to be induced during phosphate starvation. Based on amino acid sequence similarity to a bacterial phosphatidylcholine-hydrolyzing phospholipase C, six putative phospholipase Cs were identified in the Arabidopsis genome, one of which, NPC4, showed significant transcriptional activation upon phosphate limitation. Molecular cloning and functional expression of NPC4 confirmed that the NPC4 gene encoded a functional phosphatidylcholine-hydrolyzing phospholipase C that did not require Ca2+ for its activity. Subcellular localization analysis showed that NPC4 protein was highly enriched in the plasma membrane. Analyses of transferred DNA-tagged npc4 mutants revealed that disruption of NPC4 severely reduces the phosphatidylcholine-hydrolyzing phospholipase C activity in response to phosphate starvation. These results suggest that NPC4 plays an important role in the supply of both inorganic phosphate and diacylglycerol from membrane-localized phospholipids that would be used for phosphate supplementation and the replacement of polar lipids in the root plasma membrane during phosphate deprivation.
Activation of m-Calpain (Calpain II) by Epidermal Growth Factor Is Limited by Protein Kinase A Phosphorylation of m-Calpain

ABSTRACT We have shown previously that the ELR-negative CXC chemokines interferon-inducible protein 10, monokine induced by gamma interferon, and platelet factor 4 inhibit epidermal growth factor (EGF)-induced m-calpain activation and thereby EGF-induced fibroblast cell motility (H. Shiraha, A. Glading, K. Gupta, and A. Wells, J. Cell Biol. 146:243-253, 1999). However, how this cross attenuation could be accomplished remained unknown since the molecular basis of physiological m-calpain regulation is unknown. As the initial operative attenuation signal from the CXCR3 receptor was cyclic AMP (cAMP), we verified that this second messenger blocked EGF-induced motility of fibroblasts (55% ± 4.5% inhibition) by preventing rear release during active locomotion. EGF-induced calpain activation was inhibited by cAMP activation of protein kinase A (PKA), as the PKA inhibitors H-89 and Rp-8Br-cAMPS abrogated cAMP inhibition of both motility and calpain activation. We hypothesized that PKA might negatively modulate m-calpain in an unexpected manner by directly phosphorylating m-calpain. A mutant human large subunit of m-calpain was genetically engineered to negate a putative PKA consensus sequence in the regulatory domain III (ST369/370AA) and was expressed in NR6WT mouse fibroblasts to represent about 30% of total m-calpain in these cells. This construct was not phosphorylated by PKA in vitro while a wild-type construct was, providing proof of the principle that m-calpain can be directly phosphorylated by PKA at this site. cAMP suppressed EGF-induced calpain activity of cells overexpressing a control wild-type human m-calpain (83% ± 3.7% inhibition) but only marginally suppressed that of cells expressing the PKA-resistant mutant human m-calpain (25% ± 5.5% inhibition). The EGF-induced motility of the cells expressing the PKA-resistant mutant also was not inhibited by cAMP. Structural modeling revealed that new constraints resulting from phosphorylation at serine 369 would restrict domain movement and help “freeze” m-calpain in an inactive state. These data point to a novel mechanism of negative control of calpain activation, direct phosphorylation by PKA.
Björk , Tomas Working Paper On the geometry of interest rate models

In this paper, which is a substantial extension of an earlier essay [3], we give an overview of some recent work on the geometric properties of the evolution of the forward rate curve in an arbitrage free bond market. The main problems to be discussed are as follows. • When is a given forward rate model consistent with a given family of forward rate curves? • When can the inherently infinite dimensional forward rate process be realized by means of a Markovian finite dimensional state space model. We consider interest rate models of Heath-Jarrow-Morton type, where the forward rates are driven by a multidimensional Wiener process, and where he volatility is allowed to be an arbitrary smooth functional of the present forward rate curve. Within this framework we give necessary and sufficient conditions for consistency, as well as for the existence of a finite dimensional realization, in terms of the forward rate volatilities. We also study stochastic volatility HJM models, and we provide a systematic method for the construction of concrete realizations. JEL: E43, G13.
A Novel 14 nm Extended Body FinFET for Reduced Corner Effect, Self-Heating Effect, and Increased Drain Current

In this paper, we have proposed a novel FinFET with extended body under the poly gate, which is called EB-FinFET, and its characteristic is demonstrated by using three-dimensional (3-D) numerical simulation. We have analyzed and compared it with conventional FinFET. The extended body height dependence on the drain induced barrier lowering (DIBL) and subthreshold swing (S.S) have been also investigated. According to the 3-D numerical simulation, the proposed structure has a firm structure, an acceptable short channel effect (SCE), a reduced series resistance, an increased on state drain current (Ion) and a large normalized IDS. Furthermore, the structure can also improve corner effect and reduce self-heating effect due to the extended body. Our results show that the EBFinFET is excellent for nanoscale device. Keywords—SOI, FinFET, tri-gate, self-heating effect.
Towards an inhalative in vivo application of immunomodulating gelatin nanoparticles in horse-related preformulation studies

Delivering active ingredients using biocompatible and biodegradable carriers such as gelatin nanoparticles (GNPs) to the lung constitutes a promising non-invasive route of administration. However, the pulmonary delivery of nanoparticle-based immunotherapy is still a field that requires more clarification. In this study, GNPs loaded with cytosine-phosphate-guanine oligodeoxynucleotides (CpG-ODN)-loaded and plain GNPs were aerosolised either by a conventional pressured metered dose inhaler (pMDI) or by active or passive vibrating-mesh (VM) nebulisers. GNP sizes after nebulisation by active and passive VM nebulisers were 248.2 ± 7.34 and 222.3 ± 1.42 nm, respectively. GNP concentrations after aerosolisation were found consistent and second-stage particle deposition in an impinger was up to 65.68 ± 11.2% of the nebulised dose. VM nebulisers produced high fine particle fractions, while pMDIs did not. Nebulised CpG-ODN-loaded GNPs remained capable to stimulate IL-10 release (225.2 ± 56.3 pg/ml) in vitro from equine alveolar lymphocytes. Thus, a novel system for pulmonary GNP-mediated immunotherapy in vivo was established.
Political Homophily in Social Relationships: Evidence from Online Dating Behavior

Do people form relationships based upon political similarity? Past work has shown that social relationships are more politically similar than expected by chance, but the reason for this concordance is unclear. Is it because people prefer politically similar others, or is it attributable to confounding factors such as convergence, social structures, and sorting on nonpolitical characteristics? Addressing this question is challenging because we typically do not observe partners prior to relationship formation. Consequently, we leverage the domain of online dating. We first conducted a nationwide experiment in which we randomized political characteristics in dating profiles. Second, we analyzed behavioral data from a national online dating community. We find that people evaluate potential dating partners more favorably and are more likely to reach out to them when they have similar political characteristics. The magnitude of the effect is comparable to that of educational homophily and half as large as racial homophily.
Not So Fast: Inflation in Impact Factors Contributes to Apparent Improvements in Journal Quality

The Institute for Scientific Information (ISI) impact factor has become an important standard for assessing journal quality. Here we propose that impact factors may be subject to inflation analogous to changes in monetary prices in economics. The possibility of inflation came to light as a result of the observation that papers published today tend to cite more papers than those published a decade ago. We analyzed citation data from 75,312 papers from 70 ecological journals published during 1998–2007. We found that papers published in 2007 cited an average of seven more papers than those published a decade earlier. This increase accounts for about 80% of the observed impact factor inflation rate of 0.23. In examining the 70 journals we found that nearly 50% showed increases in their impact factors, but at rates lower than the background inflation rate. Therefore, although those journals appear to be increasing in quality as measured by the impact factor, they are actually failing to keep pace with inflation.
Compact Variable Gain Amplifier for a Multistandard WLAN/WiMAX/LTE Receiver

This paper presents a novel single-stage VGA architecture that employs two Gm cells, a voltage-controlled current attenuator, resistors and capacitors. The gain can be changed in three large steps by using digital controls, and continuously within these steps. The VGA bandwidth and output-related IP3 and 1dBCP are independent of the gain setting; the bandwidth can be programmed through a digitally-controlled capacitor array placed at its output. The proposed architecture was employed to realize the VGA for a WLAN/WiMAX/LTE radio receiver. Die area and power consumption were reduced by implementing the two Gm cells with one instantiation of a high-linearity Gm-core and scaled outputs; also, the current attenuator was implemented with a simple differential current steering circuit; finally, the load resistors were also used to sense the output common-mode level. The VGA was fabricated in 0.15 um standard CMOS process. Measurement results show the gain varying between -5 dB to 30 dB and the max bandwidth surpasses 60 MHz; 11.14 nV/√{Hz} input referred noise; O1dBCP of 8.6 dBm while taking 4.2 mA from a 1.8 V supply; it settles within 20 ns after a min-max step-change of the gain; it occupies 0.05 mm2.
Research collaboration and topic trends in Computer Science based on top active authors

Academic publication metadata can be used to analyze the collaboration, productivity and hot topic trends of a research community. In this paper, we study a specific group of authors, namely the top active authors. They are defined as the top 1% authors with uninterrupted and continuous presence in scientific publications over a time window. We take the top active authors in the Computer Science (CS) community over different time windows in the past 50 years, and use them to analyze collaboration, productivity and topic trends. We show that (a) the top active authors are representative of the overall population; (b) the community is increasingly moving in the direction of Team Research, with increased level and degree of collaboration; and (c) the research topics are increasingly inter-related. By focusing on the top active authors, it helps visualize these trends better. Besides, the observations from top active authors also shed light on design of better evaluation framework and resource management for policy makers in academia. ABSTRACT Academic publication metadata can be used to analyze the collaboration, productivity and hot topic trends of a research community. In this paper, we study a speciﬁc group of authors, namely the top active authors. They are deﬁned as the top 1% authors with uninterrupted and continuous presence in scientiﬁc publications over a time window. We take the top active authors in the Computer Science (CS) community over different time windows in the past 50 years, and use them to analyze collaboration, productivity and topic trends. We show that (a) the top active authors are representative of the overall population; (b) the community is increasingly moving in the direction of Team Research, with increased level and degree of collaboration; and (c) the research topics are increasingly inter-related. By focusing on the top active authors, it helps visualize these trends better. Besides, the observations from top active authors also shed light on design of better evaluation framework and resource management for policy makers in academia.
Perceptions of Sense of Control, Relative Deprivation, and Expectations of Young Jews and Palestinians in Israel

Abstract The author focused on the impact of personal deprivation, sense of control, and social context on the future expectations of advantaged and discriminated groups. Analysis of 6,430 Jewish and Palestinian high school students in Israel showed that Palestinian students had lower expectations and stronger feelings of deprivation than Jewish students. Also those who felt deprived had lower expectations regarding the prospects of marriage and the probability of owning a home and a car and of holding a permanent job. However, sense of control influenced these expectations more than did feelings of deprivation. The findings indicated that the processes by which future expectations are formed might be different for Jewish and Palestinian students and that these differences are—at least in part—related to long-term discrimination against Palestinians in Israel.
Direct observation of a transient ternary complex during IκBα-mediated dissociation of NF-κB from DNA

Significance The nuclear factor kappa B (NF-κB) family of transcription factors regulates hundreds of genes in response to stress. Stress responses must be robust when needed and then completely and rapidly turned off. A family of inhibitor proteins, the IκBs, is responsible for turning off NF-κBs. Our study shows that IκBα turns off NF-κB(RelA/p50) by rapidly binding to the DNA-bound NF-κB, forming a transient ternary complex. The ternary complex lasts for only milliseconds before the DNA dissociates from the complex. The resulting IκBα–NF-κB complex is extremely stable and cannot be dissociated. Our study shows how the macromolecular interactions of IκBα are precisely tuned to efficiently and irreversibly turn off NF-κB transcriptional activity. We previously demonstrated that IκBα markedly increases the dissociation rate of DNA from NF-κB. The mechanism of this process remained a puzzle because no ternary complex was observed, and structures show that the DNA and IκBα binding sites on NF-κB are overlapping. The kinetics of interaction of IκBα with NF-κB and its complex with DNA were analyzed by using stopped-flow experiments in which fluorescence changes in pyrene-labeled DNA or the native tryptophan in IκBα were monitored. Rate constants governing the individual steps in the reaction were obtained from analysis of the measured rate vs. concentration profiles. The NF-κB association with DNA is extremely rapid with a rate constant of 1.5 × 108 M−1⋅s−1. The NF-κB–DNA complex dissociates with a rate constant of 0.41 s−1, yielding a KD of 2.8 nM. When IκBα is added to the NF-κB–DNA complex, we observe the formation of a transient ternary complex in the first few milliseconds of the fluorescence trace, which rapidly rearranges to release DNA. The rate constant of this IκBα-mediated dissociation is nearly equal to the rate constant of association of IκBα with the NF-κB–DNA complex, showing that IκBα is optimized to repress transcription. The rate constants for the individual steps of a more folded mutant IκBα were also measured. This mutant associates with NF-κB more rapidly than wild-type IκBα, but it associates with the NF-κB–DNA complex more slowly and also is less efficient at mediating dissociation of the NF-κB–DNA complex.
AC NBTI studied in the 1 Hz -- 2 GHz range on dedicated on-chip CMOS circuits

We describe on-chip circuits specially designed and fabricated for the purpose of measuring the effect of AC NBTI on an individual, well-defined device in the wide frequency range on a single wafer. The circuits are designed to allow measurements in multiple modes, specifically, DC and AC NBTI (both interrupted and on-the-fly), on a single pFET and on a CMOS inverter, as well as charge-pumping characterization of the stressed pFET. The results indicate that AC NBTI is independent of the frequency in the 1 Hz-2 GHz range. The voltage and stress time acceleration is observed to be identical for both AC and DC NBTI stress