Miracle-dz/UniFAR-FTUs huggingface dataset:
The Air Noncoding RNA Epigenetically Silences Transcription by Targeting G9a to Chromatin

A number of large noncoding RNAs (ncRNAs) epigenetically silence genes through unknown mechanisms. The Air ncRNA is imprinted—monoallelically expressed from the paternal allele. Air is required for allele-specific silencing of the cis-linked Slc22a3, Slc22a2, and Igf2r genes in mouse placenta. We show that Air interacts with the Slc22a3 promoter chromatin and the H3K9 histone methyltransferase G9a in placenta. Air accumulates at the Slc22a3 promoter in correlation with localized H3K9 methylation and transcriptional repression. Genetic ablation of G9a results in nonimprinted, biallelic transcription of Slc22a3. Truncated Air fails to accumulate at the Slc22a3 promoter, which results in reduced G9a recruitment and biallelic transcription. Our results suggest that Air, and potentially other large ncRNAs, target repressive histone-modifying activities through molecular interaction with specific chromatin domains to epigenetically silence transcription.
The First 20 Years of Organizational Research Methods: Trajectory, Impact, and Predictions for the Future

We analyze the trajectory of Organizational Research Methods (ORM) during the first 20 years of its existence (i.e., 1998-2017). First, beginning with the inaugural volume, we review the editorials to create a qualitative account regarding ORM’s journey as narrated by the journal’s leaders in their own voices. Second, we examine the composition of the five senior editorial teams (i.e., editors and associate editors), including their qualitative-quantitative, micro-macro, and disciplinary orientation, as well as the types of articles published by ORM along the qualitative-quantitative and micro-macro distinctions. Third, we describe the 27 feature topics (i.e., set of articles addressing a common issue) published by ORM. Fourth, we offer information regarding ORM’s impact and influence based on impact factor data, journal lists, and other indicators (e.g., ORM articles that have received awards from professional organizations, most cited ORM articles out of a total of 484). Fifth, we identify the most frequently published ORM authors (and their disciplinary background) out of a total of 884 who have published at least one article. Finally, we discuss implications and outline opportunities and challenges as well as possible future directions for ORM. Overall, our review and analysis of the first 20 years of ORM allowed us to create a historical record for future generations, gain qualitative and quantitative insights into ORM’s trajectory and its impact and influence over time, and make predictions for the future of the journal and, more broadly, research on methodological issues.
Body height estimation based on tibia length in different stature groups.

Long bone length is one of the best-known indicators of human stature. Although the long bone length/height ratio differs in tall and short individuals, no detailed study has investigated whether specific formulae should be used to calculate height in different stature groups. This study proposes a new height estimation method. Body height and tibia length were measured in 121 male subjects aged 18.0-34.3 years. Three subgroups were established according to body height (short, medium, or tall), using the 15th and 85th percentiles as cutoff levels. The general formula and a group-specific regression formula were used to estimate height in each subgroup. A control group with the same properties as the study group was analyzed in the same manner. Particularly with "short" and "tall" subjects, the difference between true height and the height predicted by the group-specific formulae was smaller than the difference observed when the general formula was used. These discrepancies were statistically significant. When estimating height based on tibia length, the individual's general stature category should be taken into consideration, and group-specific formulae should be used for short and tall subjects.
Respiration & Internal Atmosphere of Avocado Fruit.

and the composition of the internal atmosphere has been studied in several fruits. In the case of the banana (Musa sapientum) and the papaya (Carica papaya), Wardlaw and Leonard (24, 25) observed the coincidence of the onset of the climacteric rise with the peak in oxygen concentration inside these fruits. With the respiratory rise the oxygen level dropped, reaching very low values of 1 % at late stages of senescence. Impressed with the marked changes in the gaseous composition, they suggested that the internal oxygen concentration is the controlling mechanism of the climacteric pattern. Trout et al. (22) reported that in mature apples oxygen deficiency depressed respiration and retarded ripening. Observations on the epidermal layers as the tissue that offers major resistance to gaseous diffusion were made by Trout et al. (22) for the apple and by Clendenning (7) for the tomato. Biale (4) included in his review a brief account of the studies dealing with the internal atmospheres of fruits. The avocado fruit is distinguished from other fruits by its low fermentative capacity, shown by depression of CO2 evolution and ripening under anaerobic conditions (3). This study was undertaken, therefore, with the purpose of finding an explanation for the physiological behavior of the avocado in terms of changes in the composition of the internal atmosphere.
Reconstruction Aid, Public Infrastructure, and Economic Development: The Case of the Marshall Plan in Italy

The Marshall Plan (1948–1952) was the largest aid transfer in history. This paper estimates its effects on Italy’s postwar economic development. It exploits differences between Italian provinces in the value of reconstruction grants they received. Provinces that could modernize their infrastructure more quickly experienced higher increases in agricultural production, especially for perishable crops. In the same provinces, we observe larger investments in labor-saving machines, the entry of more firms into the industrial sector, and a larger expansion of the industrial and service workforces.
The European venture capital landscape: an EIF perspective. Volume IV: The value of innovation for EIF-backed startups

The creation of value through innovation is among the defining traits of new technology-driven ventures. In this paper we contribute to the literature by investigating the value of innovations for start-ups supported by EIF in the years 1996 to 2014, as measured through patent applications. The paper is structured around two main parts. The first part presents a series of descriptive statistics on EIF's VC investee patent portfolio and discusses some of the strategic aspects of patenting, such as timing and geographical coverage. The second part develops an econometric model to estimate the Euro-value of innovations based on patent renewal data, following the seminal work of Pakes and Schankerman (1984). We observe that start-ups are efficient at transforming financial capital obtained through VC financing into innovative capital. On average, for every Euro of EIF-supported VC financing, start-ups generated 2.74 Euro of private innovation value.
Ad Creativity via Augmented Reality Technology in Online Video Ads: the Differential Role of Novelty, Message Usefulness, and Ad-Consumer Association

Abstract This study aims to examine the role of ad creativity in YouTube video ads featuring augmented reality (AR) technology. Through an online experiment, we compared people who hold positive preexisting attitudes toward a familiar brand, people who hold negative preexisting attitudes toward a familiar brand, and people who are unfamiliar with a brand in terms of their perceived creativity of a video ad featuring AR technology. Further, we explored the differential effect of three dimensions of ad creativity, namely, message usefulness, ad novelty, and ad-consumer association, on short and long-term brand name recall, short and long-term brand message recall, ad attitudes, and brand attitudes. Results demonstrated that for a familiar brand, people’s perceived creativity of an ad is biased by their preexisting brand attitudes. For an unfamiliar brand, since people do not hold preexisting attitudes toward it, their perceived creativity of an ad for the unfamiliar brand is mostly shaped by their ad evaluations. Moreover, results revealed that the three dimension of ad creativity play different roles in ad effectiveness.
Ion outflows and artificial ducts in the topside ionosphere at HAARP

New results of the DMSP satellite and HAARP digisonde observations during HF heating at the High‐Frequency Active Auroral Program (HAARP) facility are described. For the first time, the DMSP satellites detected significant ion outflows associated with 10–30% density enhancements in the topside ionosphere above the heated region near the magnetic zenith. In addition, coincident high‐cadence skymaps from the HAARP digisonde reveal field‐aligned upward plasma flows inside the F‐peak region. The SAMI2 2 model calculations are in fair agreement with the observations.
Cytologic diagnosis of pulmonary adenocarcinoma with micropapillary pattern: Does it correlate with the histologic findings?

Micropapillary adenocarcinoma is associated with poor‐prognosis in several organs including the lung. The presence of small tight balls of neoplastic cells devoid of fibrovascular core in cytological preparations (micropapillary tufts) has been described as characteristic of micropapillary adenocarcinoma. In the lung, however, this criterion has not been validated. The cytological material of 46 cases of histologically proven pulmonary adenocarcinoma with a micropapillary component was compared to 33 cases with no micropapillary component to determine the specificity of micropapillary tufts for the histologic diagnosis of micropapillary adenocarcinoma. Other histologic patterns of invasive pulmonary adenocarcinomas (acinar, papillary, and solid) were also compared with patterns of neoplastic cell aggregates in cytological preparations. There were no significant differences in the distribution of micropapillary clusters between the two groups. The positive predictive value for the cytologic diagnosis of a micropapillary component in lung adenocarcinomas was of 64%. Similar findings were observed for other invasive patterns. Therefore, the detection of micropapillary tufts in cytology is not specific for the diagnosis of a pulmonary micropapillary adenocarcinoma in the lung. Diagn. Cytopathol. 2009. © 2009 Wiley‐Liss, Inc.
Prenatal sonographic findings of trisomy 18: review of 47 cases

Prenatal sonographic findings were reviewed in 47 consecutive fetuses with trisomy 18. One or more abnormalities, excluding choroid plexus cysts, were found in 39 fetuses (83%), including 21 of 29 (72%) fetuses examined between 14 and 24 weeks and all 18 (100%) fetuses examined after 24 weeks. Abnormalities most frequently detected before 24 weeks included cystic hygromas, nuchal thickening, and meningomyelocele. Intrauterine growth retardation, cardiac defects, and an enlarged cisterna magna were detected more frequently after 24 weeks than before 24 weeks (P < 0.05). Intrauterine growth retardation was the single most common abnormality, detected in 51% of all fetuses and 89% of fetuses examined after 24 weeks. Choroid plexus cysts were identified in 25% (12 of 47) of fetuses, including 11 of 29 (38%) fetuses seen before 24 weeks. Additional abnormalities were identified in 10 of 12 (83%) fetuses with choroid plexus cysts; one of the two remaining fetuses showed clenched hands and a cardiac anomaly at autopsy, and the other showed unusually large, multiple choroid plexus cysts. Awareness of the type of anomalies and the usual menstrual age of diagnosis in fetuses with trisomy 18 should improve patient counseling and prenatal detection of fetuses considered at risk for this disorder.
Course in Parkinson disease subtypes

Background: Individual variations in the course of Lewy body Parkinson disease (PD) are well known. Patients have been classified into different clinical subtypes to identify differences in the course among the subgroups. Several studies indicate that the outcome is more favorable in tremor dominant (TD) cases but others report no difference. A majority of progression studies are based on cross-sectional single point data or short-term clinical observations. The lack of longitudinally followed autopsy-confirmed PD cohort remains a major weakness in the literature. Biochemical studies of brain indicate most pronounced abnormalities in akinetic/rigid (AR) and the least in TD cases. We postulate that PD course in these subtypes is concordant with the biochemical findings. Objective: To compare the course in TD, mixed (MX), and AR subtypes of PD. Methods: Longitudinal clinical follow-up and autopsy studies were performed on 166 patients with PD over 39 years (1968–2006). Patients were classified into TD, AR, and MX based on the entire clinical course. Only the pathologically confirmed PD cases were included. Results: Sixty-six percent of cases had MX, 26% AR, and 8% TD profile. The age at onset was younger (p < 0.001) and progression to Hoehn & Yahr stage 4 was slower (p = 0.016) in the TD cases. Dementia was most common in AR (p = 0.039) and the least common in TD. In general, the course was most favorable in TD, followed by MX and AR subgroups. Conclusion: The three subtypes of Parkinson disease have different courses which are concordant with the differences in brain biochemical abnormalities.
YouTube as an Airlines Marketing Tool

Abstract Multimedia communication through social media has been experiencing constantly growing significance in the field of airline marketing. The aim of the research presented in this paper was to find out and, with the help of both qualitative and quantitative analyses, describe the way YouTube is used by airlines. The research was conducted in the form of a comparative study with the objective of identifying the difference between YouTube performance of full-service carriers (FSCs) and low-cost carriers (LCCs). The intention was to identify which factors influence the effectiveness of airline marketing conducted via YouTube an as well as the way in which they do it. Analysis of selected data was facilitated by social media analytics tool SocialBakers, content analyses and a correlation analysis of YouTube metrics, selected on the base of previous research results. The research data were collected twice during the year 2017 in order to reflect changes over time. Research results showed that FSCs build their YouTube channels more systematically than LCCs. FSCs offer a substantially wider range of video topics and often sort out topics of their videos in a more detailed way. Regarding the basic metrics of YouTube channels (total number of views, number of subscribers), FSCs surpass LCCs significantly. One reason for their much higher rate of views is the fact that FSCs use celebrities more frequently, and frequently they offer high-quality impression/relationship airline presentation.
Prédire le passé et le futur: rôle des représentations motrices dans l'inference du mouvement

L’efficacite du systeme visuel est permise par un complexe reseau d’elaboration, qui s’appuie sur des structures corticales, sous-corticales et peripheriques. Le but de la presente recherche est de mieux comprendre le processus de perception visuelle du mouvement, et realiser un modele computationnel capable de reproduire les fonctionnalites humaines du tracking (suivi) d'un objet en mouvement. Ce travail de these comprend une ample recherche bibliographique, ainsi qu’une serie d’experimentations ; la these se compose de deux parties :La premiere partie a pour objet la determination des performances dans l’inference « vers le passe », d’un mouvement partiellement visible. Il s’agit de definir l’implication des informations exogenes (les signaux retiniens) et endogenes (les modeles internes de l’action observee) dans la reconstruction de la cinematique d’une cible en mouvement et partiellement occultee. Nos resultats supportent l’hypothese que le Systeme Nerveux Central adopte un mecanisme base sur le recours aux modeles internes dans la reconstruction du passe de cinematiques biologiques. La deuxieme partie complemente la premiere, et vise a identifier la structure et les caracteristiques fonctionnelles du systeme de poursuite, ainsi que a comprendre l’origine des erreurs systematiques presentes dans la localisation d’une cible chez l’homme. Nous avons developpe un modele computationnel en langage Matlab, base sur le mecanisme d’extrapolation du mouvement, qui est capable de reproduire les donnees experimentales dans la tâche de localisation
Rupture of the Pectoralis Major Muscle

We retrospectively studied 17 cases of distal pectoralis major muscle rupture to compare the results of repair in acute and chronic injuries and to compare operative and nonoperative treatment. Thirteen patients underwent surgery (six acute injuries [less than 2 weeks after injury] and seven chronic injuries) and four had nonoperative management. The mean age of the patients at injury was 29, and 10 of the 17 injuries were the result of weight lifting. Follow-up ranged from 18 months to 6 years (mean, 28 months). All patients subjectively rated strength, pain, motion, function with strenuous sporting activities, cosmesis, and overall satisfaction. Objectively, patients were examined for range of motion, deformity, atrophy, and strength. Isokinetic strength testing was performed in eight patients: six treated operatively (three acute and three chronic) and two treated nonoperatively. Overall subjective ratings were 96% in the acute group, 93% in the chronic group, and only 51% in the nonoperative group. Isokinetic testing showed that patients operated on for acute injuries had the highest adduction strength (102% of the opposite side) compared with patients with chronic injuries (94%) or nonoperative treatment (71%). There were no statistically significant subjective or objective differences in outcome between the patients treated operatively for acute or chronic injuries, but these patients fared significantly better than patients treated nonoperatively.
Selenium Supplementation does not Decrease Thyroid Peroxidase Antibody Concentration in Children and Adolescents with Autoimmune Thyroiditis

In adults, selenium supplementation decreases thyroid peroxidase antibody (TPO Ab) concentrations in patients with autoimmune thyroiditis (AIT). Our aim in this study was to investigate if selenium supplementation decreased TPO Ab and thyroglobulin antibody (Tg Ab) concentrations in children with AIT. Forty-nine patients (33 females) with newly diagnosed AIT and hypothyroidism were randomized to daily oral therapy with levothyroxine alone (group A, n = 18), levothyroxine plus 100 µg sodium-selenite (group B, n = 13), or levothyroxine plus 200 µg sodium-selenite (group C, n = 18). Mean age at diagnosis was 12.2 ± 2.2 years. All 49 patients needed a mean levothyroxine dose of 1.6 ± 0.5 µg/kg body weight to lower TSH to the treatment goal of 1–2 µU/ml, with no significant difference between groups. At study entry and after 12 months, TPO Ab concentrations were comparable in all three groups. Tg Ab concentrations decreased significantly after 12 months in group A and group C (p = 0.03 and p = 0.01), but not in group B (p = 0.06). It is our conclusion that selenium supplementation with sodium-selenite does not decrease TPO Ab concentrations in children and adolescents, neither given in the reduced dose of 100 µg daily nor given in the “adult” supplementation dose of 200 µg daily.
Operational cycle and tax liabilities as determinants of corporate credit risk

Liquidity and turnover indicators are usually mentioned as important dimensions in the corporate credit risk literature. However, these variables may reflect different firms' operational activity management and efficiency. In this article, we investigate if information on these firms' allow us to improve the assessment of firm's financial positions and in determining its probability of a bank credit default event. For this, we explore the breakdown of working capital and turnover into variables related to cash, activity indicators, investment, and tax liabilities. According to the results obtained, we observe that firms that take longer to repay their suppliers, or firms whose purchase stay longer as inventories, have higher probabilities of a credit default event. Moreover, there is evidence of a positive relationship between firms' credit risk and the share of tax liabilities in total assets. These indicators seem to be signals about a firm's financial fragilities. (JEL: G21, G33, C25)
Effects of aggregate gradations on properties of Grouted Macadam composite pavement

Grouted Macadam composite pavement (GMCP) is generally a composite pavement which is manufactured by preparing a highly workable fluid mortar which is specially designed with a very high early and 28 day strength (1 day – 45 MPa, 28 day – 105 MPa) by filling the flowing fluid mortar into a very open porous asphalt skeleton (25–32% Voids in Mix - VIM). The combination of both components will produce a semi-rigid pavement or GMCP which has the best features of both rigid concrete and flexible bituminous pavement where it will replace the conventional wearing course. This paper will investigate the significance difference of GMCP produced by the 3 different aggregate gradations by Road Engineering Association of Malaysia (REAM) in volumetric properties, durability and strength. The best quality fluid grout was chosen to fill the porous asphalt skeleton and GMCP was subjected for compression test, VIM and indirect tensile test (IDT) to check on its performance. The results show that the 3 different aggregate gradations significantly affect the volumetric properties, durability and strength. Furthermore it will also help in reducing pollution and helps with the current environmental problems.
Influence of calcium on selectivity of ion absorption process.

Several polyvalent cations affect absorption by excised plant roots similarly to calcium. Magnesium appears to be an exception. It is suggested that either the particular mechanism involved is not specific for calcium or that the polyvalent cations act via a calcium interaction. Calcium was found to have the property of drastically altering the ratio of absorption of scdium and potassium from a mixture of the two. Using lithium and Na + K solutions it was shown that the absorption system was extremely sensitive to smal1 concentrations of calcium. As little as 10/sup -6/ M calcium was suificient to cause a detectable change in absorption rates. The effect of calcium is enhanced in mixtures of sodium and potassium compared to its effect in single salt solutions. The essentially constant sum of the absorptions of sodium and potassium in spite of large changes in the ratio of absorbed sodium and potassium caused by the presence of calcium suggests a common metabolic carrier. The controlling behavior of calcium was found in the roots of six different species of plants. This may indicate a widespread occurrence. (auth)