Miracle-dz/UniFAR-FTUs huggingface dataset:
Life changes among homeless persons with mental illness: a longitudinal study of housing first and usual treatment.

OBJECTIVE This study compared the life changes of homeless people with mental illness participating in Housing First or treatment as usual and examined factors related to various changes. METHODS Semistructured narrative interviews were conducted with 219 participants in five Canadian cities at baseline; 197 were interviewed again at 18 months after random assignment to Housing First (N=119) or treatment as usual (N=78). Interviews were coded across 13 life domains, and each participant was categorized as reporting positive, mixed-neutral, or negative changes. Housing First and treatment as usual participants were compared with respect to change patterns. Thematic analysis was used to examine factors related to various changes. RESULTS The percentage of participants in Housing First reporting positive changes was more than double that for participants in treatment as usual, and treatment as usual participants were four times more likely than Housing First participants to report negative changes. Factors related to positive changes included having stable good-quality housing, increased control over substance use, positive relationships and social support, and valued social roles. Factors related to negative changes included precarious housing, negative social contacts, isolation, heavy substance use, and hopelessness. Factors related to mixed-neutral changes were similar to those for participants reporting negative changes but were less intense. CONCLUSIONS Housing First with intensive support was related to more positive changes among homeless adults with mental illness across five Canadian cities. Those with poor housing or support, more common in treatment as usual, continued to struggle. These findings are relevant for services and social change to benefit this population.
Acute and critical limb ischemia: When time is limb

Acute and critical limb ischemia post significant rates of morbidity and death, and need to be promptly recognized and treated to avoid amputation. Perfusion should be thoroughly assessed using multiple methods, and patients should be considered for revascularization (angioplasty or bypass surgery) to restore blood perfusion. Underlying conditions that need to be assessed and treated include cardiovascular disease, diabetes, and infection. Just as in acute myocardial infarction, where “time is muscle,” in many cases of vascular disease in the leg, “time is limb. ”
A noninitial segment of index sets

Let {Wk } k ≥ 0 be a standard enumeration of all recursively enumerable (r.e.) sets. If A is any class of r.e. sets, let θ A denote the index set of A, i.e., θA = {k ∣ Wk ∈ A}. The one-one degrees of index sets form a partial order ℐ which is a proper subordering of the partial order of all one-one degrees. Denote by ⌀ the one-one degree of the empty set, and, if b is the one-one degree of θB, denote by the one-one degree of . Let . Let {Ym } m≥0 be the sequence of index sets of nonempty finite classes of finite sets (classified in [5] and independently, in [2]) and denote by a m the one-one degree of Ym . As shown in [2], these degrees are complete at each level of the difference hierarchy generated by the r.e. sets. It was proved in [3] that, for each m ≥ 0, (a) a m+1 and ā m+1 are incomparable immediate successors of a m and ā m, and (b) . For m = 0, since Y 0 = θ{⌀}, it follows from (a) that (c) . Hence it follows that (d) {⌀, , a o, ā 0, a 1, ā 1 is an initial segment of ℐ.
The relationships between serum cytokine levels and tumor infiltrating immune cells and their clinical significance in colorectal cancer

Increased inflammatory cell infiltration correlates to improved survival in colorectal cancer (CRC). Development and progression of CRC is associated with alterations in serum cytokine levels but their significance is not well defined. In this study, we investigated the relationships between the serum levels of 13 cytokines and the densities of eight types of tumor infiltrating inflammatory cells and their impact on disease‐free survival (DFS), cancer‐specific survival (CSS) and overall survival (OS) in a prospectively recruited group of 147 CRC patients. There were strong positive correlations between the serum concentrations of different cytokines, as well as between the different types of tumor infiltrating immune cells, whereas the associations between serum cytokines and tumor infiltrating immune cells were generally weak. High serum IL‐12 levels associated with increased densities of peritumoral CD8+ T cells, intraepithelial CD3+ T cells and intratumoral neutrophils, while high serum CCL4 levels associated with increased densities of peritumoral CD68+ cells. In multivariate survival models, increased infiltration of intraepithelial CD3+ T cells and increased serum CCL4 associated with improved DFS, whereas higher intratumoral CD83+ dendritic cell density and increased serum interferon gamma levels associated with improved CSS and OS. Also high density of peritumoral CD3+ T cells associated with improved CSS. In conclusion, serum cytokines and tumor infiltrating immune cells in CRC represent entities with high intragroup correlations but relatively weak intergroup correlations. The results suggest that tumor infiltrating CD3+ T cells, CD83+ dendritic cells, serum CCL4 and serum interferon gamma represent relevant markers of disease outcome.
INTRA- AND INTERGENERATIONAL SOCIAL MOBILITY IN RELATION TO HEIGHT, WEIGHT AND BODY MASS INDEX IN A BRITISH NATIONAL COHORT

Summary Using a sample of 2090 father and son pairs, the extent of intra- and inter-generational social mobility (migration between social classes) was examined over a 42-year period in a British cohort in relation to height, weight and body mass index (BMI). The mean height difference between the highest and lowest social class decreased from about 4 cm in the fathers' generation to about 3 cm in the sons' generation, indicating a decline in heterogeneity in height between classes. For fathers downward intra-generational social mobility ranged between 11% and 18% while between 16% and 26% were upwardly mobile; for sons 15% were downwardly mobile and 21% upwardly mobile. On average downwardly mobile fathers were shorter by between 0.1 cm and 0.7 cm while upwardly mobile fathers were taller by, on average, 0.6 cm to 1.7 cm. For sons, the downwardly mobile were on average 0.7 cm shorter and the upwardly mobile 0.8 cm taller. For weight and BMI there were no consistent relationships with intra-generational mobility in either the fathers' or sons' generations. Inter-generationally, between 18% and 19% of sons were downwardly mobile and between 39% and 40% were upwardly mobile; the downwardly mobile were shorter by about 0.9 cm and the upwardly taller by between 0.6 cm and 1.2 cm. Sons with higher BMI were more likely to be inter-generationally downwardly mobile.
Interaction of translation factor SELB with the formate dehydrogenase H selenopolypeptide mRNA.

The SELB protein from Escherichia coli is a specialized elongation factor required for the UGA-directed insertion of the amino acid selenocysteine into selenopolypeptides. Discrimination of the UGA codon requires the presence of a recognition element within the mRNA, which is located at the 3' side of the UGA codon; a hairpin structure can be formed within this mRNA region. By gel shift assays, a specific interaction between SELB and the mRNA recognition element could be demonstrated. Footprinting experiments, using nucleases or iodine as cleaving agents, showed that SELB binds to the loop region of the hairpin structure. In the presence of selenocysteinyl-tRNA, SELB formed a complex with the charged tRNA and the mRNA. The results indicate that targeted insertion of selenocysteine is accomplished by the binding of the SELB protein to this mRNA recognition element, resulting in the formation of a selenocysteinyl-tRNA.SELB complex at the mRNA in the immediate neighborhood of the UGA codon.
Lignin decomposition is sustained under fluctuating redox conditions in humid tropical forest soils

Lignin mineralization represents a critical flux in the terrestrial carbon (C) cycle, yet little is known about mechanisms and environmental factors controlling lignin breakdown in mineral soils. Hypoxia is thought to suppress lignin decomposition, yet potential effects of oxygen (O2) variability in surface soils have not been explored. Here, we tested the impact of redox fluctuations on lignin breakdown in humid tropical forest soils during ten‐week laboratory incubations. We used synthetic lignins labeled with 13C in either of two positions (aromatic methoxyl or propyl side chain Cβ) to provide highly sensitive and specific measures of lignin mineralization seldom employed in soils. Four‐day redox fluctuations increased the percent contribution of methoxyl C to soil respiration relative to static aerobic conditions, and cumulative methoxyl‐C mineralization was statistically equivalent under static aerobic and fluctuating redox conditions despite lower soil respiration in the latter treatment. Contributions of the less labile lignin Cβ to soil respiration were equivalent in the static aerobic and fluctuating redox treatments during periods of O2 exposure, and tended to decline during periods of O2 limitation, resulting in lower cumulative Cβ mineralization in the fluctuating treatment relative to the static aerobic treatment. However, cumulative mineralization of both the Cβ‐ and methoxyl‐labeled lignins nearly doubled in the fluctuating treatment relative to the static aerobic treatment when total lignin mineralization was normalized to total O2 exposure. Oxygen fluctuations are thought to be suboptimal for canonical lignin‐degrading microorganisms. However, O2 fluctuations drove substantial Fe reduction and oxidation, and reactive oxygen species generated during abiotic Fe oxidation might explain the elevated contribution of lignin to C mineralization. Iron redox cycling provides a potential mechanism for lignin depletion in soil organic matter. Couplings between soil moisture, redox fluctuations, and lignin breakdown provide a potential link between climate variability and the biochemical composition of soil organic matter.
Erasure node: performance improvements for the IEEE 802.6 MAN

Proposes and analyzes a method for increasing the efficiency of a slotted multiaccess data communications network. The unique aspect of this method is that high efficiency can be achieved without much increase in latency or complexity at stations. The necessary hooks for its implementation have been incorporated into the distributed queue dual bus (DQDB) protocol, which is being standardized by the IEEE 802.6 Committee for metropolitan area networks (MANs). The proposed method, originally presented as a contribution for the MAN standards, allows slots to be reused once they reach their destination while retaining the inherent low-latency implementation and simple OR write physical interface for stations in the original scheme. The results of tests of network throughput increase as a function of traffic locality and of the number and location of erasure nodes are discussed. <<ETX>>
Simple and Complex Working Memory Tasks Allow Similar Benefits of Information Compression

Complex working memory span tasks were designed to engage multiple aspects of working memory and impose interleaved processing demands that limit the use of mnemonic strategies, such as chunking. Consequently, the average span is usually lower (4 ± 1 items) than in simple span tasks (7 ± 2 items). One possible reason for the higher span of simple span tasks is that participants can take advantage of the spare time to chunk multiple items together to form fewer independent units, approximating 4 ± 1 chunks. It follows that the respective spans of these two types of tasks could be equal (at around 4 ± 1) if stimulus lists exclusively used nonchunkable stimulus items. To manipulate the chunkability of the stimulus lists, our method involved a measure of their compressibility, i.e., the extent to which a pattern exists that can be detected and used as a basis of chunk formation. We predicted an interaction between the types of tasks and chunkability/compressibility, supporting a single higher span for the condition in which a simple span task was combined with chunkable items. The three other conditions were predicted to prevent chunking processes, either because the interleaved processing task did not allow any chunking process to occur or because the noncompressible material inherently limited the chunkability of information. The prediction that chunking is important solely in simple spans was not confirmed: Effects of information compression contributed to performance levels to a similar extent in both tasks according to a theoretically-based metric. This result suggests that i) complex span tasks might overestimate storage capacity in general, and ii) the difference between simple and complex span performance levels must rest in some mechanism other than prevention of a chunking strategy by the interleaved processing task in complex span tasks.
Comparison of indices of ambient exposure to 60-hertz electric and magnetic fields.

Occupational, environmental, or domestic exposure of human beings to extremely low-frequency (50- or 60-Hz) electric and magnetic fields varies continuously over time. In epidemiological studies of possible health effects, exposures over long durations must be aggregated in terms of simple summary indices. However, there are many different, biologically plausible, ways of aggregating the data. While awake, each of 20 electric utility personnel and 16 office workers had provided minute-by-minute measures of incident electric (V/m) and magnetic (muT) fields over a 7-day period via personal dosimeters. Once the measures were aggregated as means, medians, peaks, and other indices, intercorrelations between all index pairs were calculated; correlation matrices are presented for the utility and office workers both by group and when pooled. Product-moment coefficients (r) greater that . 80 were found between the time-weighted arithmetic mean (TWA) and indices that explicitly emphasize short but highly intense exposures, such as peak values and time above thresholds. Medians and geometric means were less highly correlated with the TWA. Use of only a few indices, perhaps the TWA alone, may sacrifice but little statistical power in most epidemiological studies of utility workers exposed to ELF fields. However, correlations between electric-field strength and magnetic-field density were generally quite weak, as were correlations of either with high-frequency transients; these findings underscore the need to measure each of these variables in epidemiological studies. Indices of exposure incurred outside the workplace were less strongly correlated, which may indicate the need to use several indices in general-population studies.
Hippocampal‐dependent spatial memory functions might be lateralized in rats: An approach combining gene expression profiling and reversible inactivation

The hippocampus is involved in spatial memory processes, as established in a variety of species such as birds and mammals including humans. In humans, some hippocampal‐dependent memory functions may be lateralized, the right hippocampus being predominantly involved in spatial navigation. In rodents, the question of possible lateralization remains open. Therefore, we first microdissected the CA1 subregion of the left and right dorsal hippocampi for analysis of mRNA expression using microarrays in rats having learnt a reference memory task in the Morris water‐maze. Relative to untrained controls, 623 genes were differentially expressed in the right hippocampus, against only 74 in the left hippocampus, in the rats that had learnt the hidden platform location. Thus, in the right hippocampus, 299 genes were induced, 324 were repressed, and about half of them participate in signaling and transport, metabolism, and nervous system functions. In addition, most differentially expressed genes associated with spatial learning have been previously related to synaptic plasticity and memory. We then subjected rats to unilateral (left or right) or bilateral reversible functional inactivations in the dorsal hippocampus; lidocaine was infused either before each acquisition session or before retrieval of a reference spatial memory in the Morris water maze. We found that after drug‐free acquisition, right or bilateral lidocaine inactivation (vs. left, or bilateral phosphate buffered saline (PBS) infusions) of the dorsal hippocampus just before a delayed (24 h) probe trial impaired performance. Conversely, left or bilateral hippocampus inactivation (vs. right, or bilateral PBS infusions) before each acquisition session weakened performance during a delayed, drug‐free probe trial. Our data confirm a functional association between transcriptional activity within the dorsal hippocampus and spatial memory in the rat. Further, they suggest that there could be a leftward bias of hippocampal functions in engram formation or information transfer, and a rightward bias in spatial memory storage/retrieval processes. © 2009 Wiley‐Liss, Inc.
Identification of LATE BLOOMER2 as a CYCLING DOF FACTOR Homolog Reveals Conserved and Divergent Features of the Flowering Response to Photoperiod in Pea

Identification of LATE BLOOMER2 in pea as a CYCLING DOF FACTOR gene sheds light on the mechanism of long-day photoperiodism, a crucial factor for the spread and cultivation of many crop species. The molecular pathways responsible for the flowering response to photoperiod have been extensively studied in Arabidopsis thaliana and cereals but remain poorly understood in other major plant groups. Here, we describe a dominant mutant at the LATE BLOOMER2 (LATE2) locus in pea (Pisum sativum) that is late-flowering with a reduced response to photoperiod. LATE2 acts downstream of light signaling and the circadian clock to control expression of the main photoperiod-regulated FT gene, FTb2, implying that it plays a primary role in photoperiod measurement. Mapping identified the CYCLING DOF FACTOR gene CDFc1 as a strong candidate for LATE2, and the late2-1D mutant was found to carry a missense mutation in CDFc1 that impairs its capacity to bind to the blue-light photoreceptor FKF1 in yeast two-hybrid assays and delays flowering in Arabidopsis when overexpressed. Arabidopsis CDF genes are important negative regulators of CONSTANS (CO) transcription, but we found no effect of LATE2 on the transcription of pea CO-LIKE genes, nor on genes in any other families previously implicated in the activation of FT in Arabidopsis. Our results reveal an important component of the pea photoperiod response pathway and support the view that regulation of FTb2 expression by photoperiod occurs via a CO-independent mechanism.
Personal, Financial, and Structural Barriers to Immunization in Socioeconomically Disadvantaged Urban Children

Objective. To evaluate personal, financial, and structural barriers to vaccination in socioeconomically disadvantaged urban children in the first 2 years of life. Design. Prospective cohort study. Setting. A large municipal teaching hospital in the Midwest. Participants. Healthy term newborns discharged to the care of their mothers. Mothers were interviewed 24 to 72 hours postpartum regarding personal and financial barriers, and 2 years later regarding personal, financial, and structural barriers to care. Main Outcome Measure. Vaccination status at age 2 years. Results. Of 399 children with documented vaccination status, 47% had not received all recommended vaccinations by 2 years of age. After adjusting for mother's age, race, and education, mothers who were unmarried (adjusted odds ratio [AOR] 1.74; 95% confidence interval [CI]: 1.05, 2.90), multiparous (AOR 2.10; 95% CI: 1.26, 3.52), not coresident with the child's grandmother (AOR 1.75; 95% CI: 1.01, 3.03), had not received adequate prenatal care (AOR 1.78; 95% CI: 1.12, 2.84), or lived in poverty (AOR 2.62; 95% CI: 1.44, 4.75) were more likely to have undervaccinated children, as were mothers who perceived less satisfaction with their child's health care (AOR 1.63; 95% CI: 1.01, 2.61), less control over their lives (AOR 2.01; 95% CI: 1.03, 3.94), or more benefit of medical care to prevent vaccine-related diseases (AOR 1.76; 95% CI: 1.25, 2.48). Conclusions. Family environment, a mother's history of prenatal care use, and financial barriers are important factors related to vaccination receipt among socioeconomically disadvantaged children at age 2 years. These factors, however, do not fully explain the variation in vaccination status.
Interstitial PDT for vascular anomalies

Photodynamic therapy is a proven therapeutic modality in the management of variety of pathologies involving the human body. Our aim in this clinical study is to prospectively evaluate the outcome following interstitial photodynamic therapy for patients with vascular anomalies. Patients' reports on quality of life with clinical and radiological evaluation were the main end point parameters used to assess the outcome.
Ferritin H- and L-chains in fiber cell canine and human lenses of different ages.

PURPOSE This study was designed to elucidate potential age-related changes in the concentration, structure, and assembly pattern of ferritin chains in lens fiber cells. METHODS Canine and human lens fiber cell homogenate proteins were separated by one-dimensional and two-dimensional SDS-PAGE. Ferritin chains were immunodetected and quantitated with ferritin chain-specific antibodies. Total ferritin concentration was measured by ELISA. Binding of iron was determined in vitro with (59)Fe. RESULTS Ferritin H- and L-chains in canine and human fiber cells of healthy lenses were extensively modified. The H-chain in both species was truncated, and its concentration increased with age. Canine L-chain was approximately 11 kDa larger than standard canine L-chain, whereas human L-chain was of the proper size. Two-dimensional separation revealed age-related polymorphism of human and canine lens fiber cell L-chains and human H-chains. Normal size ferritin chains were not identified in canine fiber cells, but a small amount of fully assembled ferritin was detected, and its concentration decreased with age. CONCLUSIONS Such significantly altered ferritin chains are not likely to form functional ferritin capable of storing iron. Therefore, lens fiber cells, particularly from older lenses, may have limited ability to protect themselves against iron-catalyzed oxidative damage.
Alternative Splicing of MLH 1 Messenger RNA in Human Normal Cells 1

The hMI.IlI protein, composed of 756 amino acids, is the human homologue of the bacterial DNA mismatch repair protein Muti,, and germ line mutations of the li.MlJII gene have been identified in kindreds with hereditary nonpolyposis colorectal cancer. We have detected three alter natively spliced forms of liMI.III mRNA in normal lymphocytes and tissues. One of the spliced forms lacks the coding region of hMLHl from codons 227 to 295 and the two other transcripts are predicted to encode two truncated proteins retaining the 264 and 226 N-terminal amino acids of hMLHl, respectively. The biological significance of this alternative splicing remains to be established.