Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of human leukocyte antigen mismatching on outcomes of living donor liver transplantation for primary biliary cirrhosis

Patient selection criteria of deceased donor liver transplantation for primary biliary cirrhosis (PBC) are almost completely established. The aim of this study was to establish selection criteria for both patients and donors of living donor liver transplantation (LDLT) for PBC. We used univariate and multivariate analyses to examine patient and donor characteristics of our first 50 cases of LDLT for PBC to elucidate factors that significantly impacted patient survival or disease recurrence after LDLT in the univariate and/or multivariate analyses. Multivariate analysis demonstrated that the presence of persistent ascites before LDLT, a higher number of human leukocyte antigen (HLA)‐A, ‐B, and ‐DR mismatches between donor and recipient, and donor age ≥50 years were factors significantly associated with early posttransplant death. Independent risk factors for PBC recurrence after LDLT were a lower number of HLA mismatches between donor and recipient, and a lower average trough level of tacrolimus within 1 year after LDLT. Specifically, the lower the number of HLA‐A, ‐B, and ‐DR mismatches or the average trough level of tacrolimus within 1 year after LDLT, the higher the possibility of developing a recurrence of PBC. In conclusion, the absence of persistent ascites before LDLT, a lower number of HLA‐A, ‐B, and ‐DR mismatches between donor and recipient, and a younger donor (<50 years) are preferred for gaining acceptable survival outcomes for the transplant. However, a lower number of HLA‐A, ‐B, and ‐DR mismatches between donor and recipient may be a risk factor for PBC recurrence. Liver Transpl, 2006. © 2006 AASLD.
Molecular Determinants of Vectofusin-1 and Its Derivatives for the Enhancement of Lentivirally Mediated Gene Transfer into Hematopoietic Stem/Progenitor Cells*

Gene delivery into hCD34+ hematopoietic stem/progenitor cells (HSPCs) using human immunodeficiency virus, type 1-derived lentiviral vectors (LVs) has several promising therapeutic applications. Numerous clinical trials are currently underway. However, the efficiency, safety, and cost of LV gene therapy could be ameliorated by enhancing target cell transduction levels and reducing the amount of LV used on the cells. Several transduction enhancers already exist, such as fibronectin fragments or cationic compounds. Recently, we discovered Vectofusin-1, a new transduction enhancer, also called LAH4-A4, a short histidine-rich amphipathic peptide derived from the LAH4 family of DNA transfection agents. Vectofusin-1 enhances the infectivity of lentiviral and γ-retroviral vectors pseudotyped with various envelope glycoproteins. In this study, we compared a family of Vectofusin-1 isomers and showed that Vectofusin-1 remains the lead peptide for HSPC transduction enhancement with LVs pseudotyped with vesicular stomatitis virus glycoproteins and also with modified gibbon ape leukemia virus glycoproteins. By comparing the capacity of numerous Vectofusin-1 variants to promote the modified gibbon ape leukemia virus glycoprotein-pseudotyped lentiviral vector infectivity of HSPCs, the lysine residues on the N-terminal extremity of Vectofusin-1, a hydrophilic angle of 140° formed by the histidine residues in the Schiffer-Edmundson helical wheel representation, hydrophobic residues consisting of leucine were all found to be essential and helped to define a minimal active sequence. The data also show that the critical determinants necessary for lentiviral transduction enhancement are partially different from those necessary for efficient antibiotic or DNA transfection activity of LAH4 derivatives. In conclusion, these results help to decipher the action mechanism of Vectofusin-1 in the context of hCD34+ cell-based gene therapy.
Characterizing Hydraulic Conductivity with the Direct‐Push Permeameter

The direct‐push permeameter (DPP) is a promising approach for obtaining high‐resolution information about vertical variations in hydraulic conductivity (K) in shallow unconsolidated settings. This small‐diameter tool, which consists of a short screened section with a pair of transducers inset in the tool near the screen, is pushed into the subsurface to a depth at which a K estimate is desired. A short hydraulic test is then performed by injecting water through the screen at a constant rate (less than 4 L/min) while pressure changes are monitored at the transducer locations. Hydraulic conductivity is calculated using the injection rate and the pressure changes in simple expressions based on Darcy’s Law. In units of moderate or higher hydraulic conductivity (more than 1 m/d), testing at a single level can be completed within 10 to 15 min. Two major advantages of the method are its speed and the insensitivity of the K estimates to the zone of compaction created by tool advancement. The potential of the approach has been assessed at two extensively studied sites in the United States and Germany over a K range commonly faced in practical field investigations (0.02 to 500 m/d). The results of this assessment demonstrate that the DPP can provide high‐resolution K estimates that are in good agreement with estimates obtained through other means.
Independent and Interdependent Self-Construals do Not Predict Analytic or Holistic Reasoning

Independent self-construals in Western cultures may promote analytic information processing and low field dependence, while interdependent self-construals in Eastern cultures may foster holistic information processing and high field dependence. To examine these ideas, the social orientation and cognitive style of 254 introductory psychology students were measured. Multiple regression analyses indicated a non-significant relationship between the participants' social orientation and cognitive style (R2s ranged from .00 to .01, 95% confidence intervals for R2 ranged from .00 to .05). These findings indicate that the hypothesis that collectivism and individualism are associated with differences in information processing between individuals needs further scrutiny. The possible reasons for the lack of association between social orientation and cognitive style are discussed.
Cytogenetic analysis of peripheral blood lymphocytes of hospital staff occupationally exposed to low doses of ionizing radiation

Ionizing radiation is known to induce mutations and cell transformations, predominantly by causing single-strand and double-strand DNA breakage, thereby leading to chromosome instability and carcinogenesis. The aim of this study was to evaluate genotoxic effects in hospital staff exposed to low-dose ionizing radiation in comparison with a selected control group, by using the cytokinesis-blocked micronucleus (CBMN) and sister chromatid exchange (SCE) tests in peripheral blood lymphocytes. The study included 40 exposed radiology staff and 30 control subjects. The frequency of micronuclei (MN) was significantly increased in radiation-exposed groups compared with control persons (p < 0.05). The frequency of SCE did not show any significant difference in the exposed individuals in comparison to the controls. Our results showed that low-level chronic occupational exposure to ionizing radiation causes an increase of MN frequency in chromosomes, even though the absorbed doses were below the permissible limits. Our studies indicate that the CBMN assay is considered to be sensitive test in contrast to SCE analysis to evaluate chromosomal damage induced by ionizing radiation.
The effects of drugs on endocrine function

(1) Effects which can be predicted from the endocrine pharmacology of compounds in therapeutic doses, e.g. oestrogen preparations increasing thyroxine binding globulin (TBG) capacity. (2) Effects which can be predicted from the endocrine pharmacology of the compound when administered in excessive doses, e.g. prolonged use of high dose glucocorticoids causing adrenal suppression. (3) Effects which could not have been predicted from the pharmacology of the compound, e.g. calcium channel blockers’ association with gynaecomastia (Tanner & Bosco, 1988).
Decision Style and Work Satisfaction of Arab Gulf Executives: A Cross-national Study

Work satisfaction and managerial decision style are crucial to the functioning of business organizations, and studies of these variables have been receiving increasing attention. Work satisfaction is closely related to individual well-being and is a major variable in organizational life. It is naturally a popular topic in both applied and theoretical studies [1-3]. Decision-making is probably the most important function of the manager, as it is the variable upon which the success or failure of any organization depends [4-5]. Increasing organizational effectiveness requires an understanding of the individual's perception of his job. Performance depends in large part on how individual managers are able to adjust to the psychological aspects of jobs, such as the types of rewards received, stress, and the perceived expectations of other members of the organization [6]. While psychological and behavioral problems are readily identifiable in many developing nations, most research in the behavioral sciences has been conducted in industrially advanced countries [7]. In their quest for economic progress, developing nations face major problems in improving the quality of work life, productivity,
Chance-Constrained Outage Scheduling Using a Machine Learning Proxy

Outage scheduling aims at defining, over a horizon of several months to years, when different components needing maintenance should be taken out of operation. Its objective is to minimize operation-cost expectation while satisfying reliability-related constraints. We propose a data-driven distributed chance-constrained optimization formulation for this problem. To tackle tractability issues arising in large networks, we use machine learning to build a proxy for predicting outcomes of power system operation processes in this context. On the IEEE-RTS79 and IEEE-RTS96 networks, our solution obtains cheaper and more reliable plans than other candidates. All our code (Matlab) is publicly available at https://github.com/galdl/outage_scheduling.
Integrating the cognitive and physiological aspects of craving

'Craving is generally considered a significant factor in opiate addiction that is associated with drug-dependence and in relapse to drug use after treatment'—ARC expert consensus (Pickens and Johanson, Drug and Alcohol Dependence 30: 127-131). There are however difficulties in defining craving and urges to use drugs and in associating craving with drug use and relapse. Tiffany [Psychological Review 97(2): 147-168] has reviewed a considerable number of studies that associated reports of craving with consumption measures of drugs and revealed only an overall modest correlation of 0.4. These findings call into question the general assumption that subjective cravings are invariably associated with drug use. Furthermore, it led to Tiffany's provocative argument that cravings are not necessary for drug use. We have addressed these issues by using a range of complementary techniques derived from research in related fields such as the cognitive psychology of anxiety and depression, physiological response measurements and positron emission tomography (PET) neuro-imaging. Initially we developed computerized assessments to probe cognitive dysfunction in addiction that related to biased processing of automatic thoughts and beliefs about craving and drug use in opiate-dependent subjects and alcoholics. Subsequently in an attempt to develop a reliable method of inducing craving we explored an imagery-based technique that relied on the memory of craving experiences. These experiments were conducted both in opiate addicts who had achieved abstinence and in those undergoing detoxification. Finally, we have begun a study to understand the neural mechanisms of craving using imagery-based procedures at the same time as performing PET studies of regional blood flow using the O15 -labelled water technique.
Maternal hepatic growth response to pregnancy in the mouse

Pregnancy is characterized by physiological adjustments in the maternal compartment. In this investigation, the influence of pregnancy on maternal liver was examined in CD-1 mice. Dramatic changes were observed in the size of the maternal liver during pregnancy. Livers doubled in weight from the non-pregnant state to day 18 of pregnancy. The pregnancy-induced hepatomegaly was a physiological event of liver growth confirmed by DNA content increase and detection of hepatocyte hyperplasia and hypertrophy. Growth of the liver was initiated following implantation and peaked at parturition. The expression and/or activities of key genes known to regulate liver regeneration, a phenomenon of liver growth compensatory to liver mass loss, were investigated. The results showed that pregnancy-dependent liver growth was associated with interleukin (IL)-6, tumor necrosis factor α, c-Jun and IL-1β, but independent of hepatocyte growth factor, fibroblast growth factor 1, tumor necrosis factor receptor 1, constitutive androstane receptor and pregnane X receptor. Furthermore, maternal liver growth was associated with the activation of hepatic signal transducer and activator of transcription 3, β-catenin and epidermal growth factor receptor, but pregnancy did not activate hepatic c-Met. The findings suggest that the molecular mechanisms regulating pregnancy-induced liver growth and injury-induced liver regeneration exhibit overlapping features but are not identical. In summary, the liver of the mouse adapts to the demands of pregnancy via a dramatic growth response driven by hepatocyte proliferation and size increase.
Causality Relationship Between Import, Export and Growth Rate in Developing Countries

In this paper, we tried to determine the relationship between imports, exports and growth rate in developing countries. Within this scope, 6 developing countries (Argentina, Brazil, China, Malaysia, Mexico and Turkey) were analyzed in this study. In order to achieve this purpose, annual data for the periods between 1961 and 2014 was tested by using Engle Granger co-integration analysis, Vector Error Correction Model and Toda Yamamoto causality analysis. According to the result of the analysis, it was determined that there is not any relationship among three variables in Brazil and Mexico. On the other hand, we defined that increase in export causes higher growth rate in Argentina. Moreover, it was concluded that there is a causal relationship from import to export in China and Turkey. Furthermore, it was determined that export causes higher import in Malaysia. Therefore, it can be concluded that the relationship between import, export and growth rate is not same for all developing countries.
Incidence of occult cerebrospinal fluid fistula during paranasal sinus surgery.

OBJECTIVE To determine the incidence of occult cerebrospinal fluid fistulas after endoscopic paranasal sinus surgery. DESIGN Prospective diagnostic test study with a 6-month follow-up in case of cerebrospinal fluid detection. SETTING Tertiary care hospital. SUBJECTS The study population comprised 69 patients undergoing routine endoscopic paranasal sinus surgery. Patients with an obvious intraoperative or postoperative cerebrospinal fluid fistula were not included. INTERVENTION Analysis of 112 samples from intraoperative applied tamponades and of 69 serum samples using a nephelometric research assay for beta-trace protein (prostaglandin D synthase). MAIN OUTCOME MEASURES Incidence of occult cerebrospinal fluid fistula during endoscopic paranasal sinus surgery as indicated with the help of a test for beta-trace protein; at least a 6-month follow-up of patients with an occult cerebrospinal fluid fistula; and relation of occult cerebrospinal fluid fistula with surgical experience of the surgeon. RESULTS Beta-trace protein was found in ethmoid roof samples from 2 patients, giving an incidence of 2.9% for occult cerebrospinal fluid fistula. Both patients were operated on by very experienced surgeons. Signs of a cerebrospinal fluid fistula were not found at follow-up at least 6 months after surgery. CONCLUSIONS Nephelometric beta-trace protein assay is a highly sensitive method to detect otherwise unobserved cerebrospinal fluid fistulas. The clinical course of the 2 patients with an occult cerebrospinal fluid fistula indicated the possibility of an uneventful follow-up of patients with small fistulas.
Cache Friendly Strategies to Optimize Matrix Multiplication

Matrix multiplication is an operation used in many algorithms with a plethora of applications ranging from Image Processing, Signal Processing, to Artificial Neural Networks and Linear algebra. This work aims to showcase the effect of developing matrix multiplication strategies that are less time and processor intensive by effectively handling memory accesses. The paper also touches upon on the advantages of using OpenMP, a multiprocessing toolkit to show the effect of parallelizing matrix multiplication.
Characterization of Angular Spread in Underground Tunnels Based on the Multimode Waveguide Model

One of the biggest challenges facing wireless designers is determining how to configure multiple-input-multipleoutput (MIMO) antennas in underground-environments, such as mines, so that they deliver best performance. Here, we showed that angular dispersion of the signal, a phenomenon that greatly impacts channel capacity, can be accurately predicted in both near-field and far-field of underground tunnels using a multimode waveguide. Not only this analytical model is much faster than other methods, but also it does not have other shortcomings of measurement-based modeling (e.g., poor resolution for far distances in the tunnel). Further, we characterized angular-spread for different tunnel sizes and showed that the power-azimuthspectrum can be modeled by a zero-mean Gaussian distribution whose standard-deviation (angular-spread) is dependent on the tunnel dimension and the transmitter-receiver distance. Angular-spread is found to be a decreasing function of axial distance. After a certain distance, it becomes very small (about 4°) and independent of tunnel transverse dimension. Our results are useful for design of MIMO systems in underground tunnels and sufficient to permit the correlation-matrix required to extend the IEEE 802.11n MIMO channel model to underground environments.
Long-term modulation of inward currents in O2 chemoreceptors by chronic hypoxia and cyclic AMP in vitro

In mammals, ventilatory acclimatization to hypoxia is associated with an enhanced chemosensitivity of the O2-sensing carotid body, resulting in an increased respiratory drive. To test whether this sensitization involves long-term modulation of ion channel function in endogenous O2 chemoreceptors, i.e., type 1 cells, we exposed cultures of dissociated rat carotid body to chronic hypoxia (6% O2) for 1–2 weeks, before monitoring the electrophysiological properties of type 1 cells using whole-cell, perforated patch recording. Chronic hypoxia augmented voltage-dependent inward Na+ and Ca2+ currents in type 1 cells, without significant changes in voltage dependence of activation or steady-state inactivation. However, after normalizing for the concomitant increase in cell size, indicated by the whole-cell capacitance, only the Na+ current density was significantly enhanced. The Na+ current was sensitive to tetrodotoxin (TTX; 0.5–1 microM) or choline substitution, whereas most of the Ca2+ current was sensitive to the L-type calcium channel blocker, nifedipine (10 microM). Several of these effects of hypoxia were mimicked qualitatively by growing normoxic cultures in the presence of agents that elevate intracellular cyclic AMP, including dibutyryl cAMP (db-cAMP; 200 microM-1 mM) and forskolin (10 microM); treatment with similar concentrations of dibutyryl cyclic GMP was ineffective. Na+ channel induction by db-cAMP was abolished by the protein synthesis inhibitor, cycloheximide (90–180 microM). In current- clamp mode, these altered chemoreceptors had typical resting potentials of approximately -55 mV, and following depolarization often fired multiple spikes that appeared to consist of both short-duration Na+ and long-duration Ca2+ components. We propose that chronic hypoxia, acting in part through cAMP-dependent pathways, increases electrical excitability and calcium mobilization in type 1 cells, and these adaptations may help enhance chemosensitivity during hypoxic acclimatization.
Molecular Divergence Defines Two Distinct Lineages of Crithidia bombi (Trypanosomatidae), Parasites of Bumblebees

ABSTRACT. This study provides, for the first time, sequence data for the protozoan flagellates Crithidia bombi and Crithidia mellificae (Kinetoplastea: Trypanosomatidae). We amplified the partial sequences of the small subunit ribosomal RNA (SSU rRNA), glycosomal glyceraldehyde phosphate dehydrogenase (gGAPDH), cytochrome b (Cyt b), and the complete internal transcribed spacer region 1 (ITS1) of the ribosomal RNA gene region for 66 clones of C. bombi from Switzerland and Alaska. Furthermore, we sequenced the same stretch of SSU rRNA and gGAPDH for one isolate of C. mellificae from Switzerland. All four molecular markers classified the C. bombi samples into two distinct lineages A and B. Both lineages were found in the two sampling locations. Variation within lineages was small or non‐existing. Sequence differences between lineages were 1.64% for SSU rRNA, 4.36% for gGAPDH, and 12.02% for Cyt b. The ITS1‐sequences of lineages A and B have diverged so much that no alignment was possible. With regard to ITS1, we additionally found fragment length polymorphism (variation in microsatellite repeat numbers) as well as nucleotide diversity within each lineage. Furthermore, the sequences of SSU rRNA and gGAPDH of C. mellificae were different from both lineages of C. bombi. The separation of lineages A and B, based on sequence differences and phylogenetic reconstruction, is so pronounced as to characterize two species of “C. bombi. ” We propose to retain C. bombi for the more common lineage A and suggest the name Crithidia expoeki n. sp. for lineage B.
Data-Driven Stochastic Transmission Expansion Planning

Due to the significant improvements of power generation technologies and the trend of replacing traditional power plants with renewable generation resources, the generation portfolio will experience dramatic changes in the near future. The uncertainty and variability of renewable energy and their sitting call for strategic and economic plans for expanding the transmission capacities. In this study, we develop a data-driven two-stage stochastic transmission expansion planning with uncertainties. In the proposed approach, purely by learning from the historical data, we first construct a confidence set for the unknown distribution of the uncertain parameters. Then, we develop a two-stage data-driven transmission expansion framework, by considering the worst-case distribution within the constructed confidence set, so as to provide a reliable while economic transmission planning decision. Furthermore, to tackle the model complexity, we propose a decomposition framework embedded with Benders’ and Column-and-Constraint generation methods. We implement our approach on 6-bus and 118-bus systems to test its effectiveness. Finally, we show as the amount of historical data grows, the conservativeness of the model decreases.
An evaluation framework for peer-based youth programs

Peer-based programs are increasingly used by community organisations to support vulnerable youth who are at risk of developing mental health problems. Such programs are as diverse as the populations they support and include drop-in services, peer education, camps and online discussion forums for hard-to-reach populations that may not access more conventional forms of support owing to issues of stigma or accessibility (for example,