Miracle-dz/UniFAR-FTUs huggingface dataset:
Variation in Blame Attributions across Different Cancer Types

Background: Cancer communication has begun to focus on prevention through lifestyle change. One possible consequence of this is that attitudes towards people with certain types of cancer could become increasingly negative. In this study, we assessed attributions of blame for five common cancers. Methods: Data were collected as part of a population-based survey of women's attitudes to cancer. A sample of 1,620 women rated how much they would blame someone who had a diagnosis of breast cancer, cervical cancer, bowel cancer, lung cancer, and leukemia, as well as chlamydia and obesity. Results: Few women attributed any blame for someone with leukemia or breast cancer (9% and 15%). The proportions attributing some blame for bowel cancer and cervical cancer were slightly higher (23% and 37%). Patients with lung cancer were considered at least partly to blame by 70% of respondents, approaching chlamydia (87%) and obesity (96%). Attributions of blame for bowel, cervical, and lung cancer were most common among those with more qualifications, and women who knew that cervical cancer was linked to sexual activity were more likely to attribute blame to it (48% versus 32%). Conclusions: Cancers are not generally seen as a matter of personal responsibility, but lung cancer, and to a lesser extent, cervical and bowel cancer do attract blame attributions. Knowledge of the preventability of cancer seems to be associated with perceived responsibility. Impact: Increasing awareness of the preventable nature of some cancers might affect blame attributions. Additional research is needed to explore the implications of these findings. Cancer Epidemiol Biomarkers Prev; 19(7); 1799–805. ©2010 AACR.
Foreseeing the future: Occurrence probability of imagined future events modulates hippocampal activation

Episodic memory and episodic future thinking are known to share a set of brain regions. Potential differences in activation patterns associated with the two conditions are as yet inconclusive, in particular with respect to hippocampal involvement. Hippocampal activation is modulated by a range of phenomenal qualities during the imagination of both past and future events (Addis et al. ( 2004 ) Hippocampus 14:752–762; Addis and Schacter ( 2008 ) Hippocampus 18:227–237). A relevant variable in this regard is the occurrence probability of an episode, which varies for future but not past events and thus cannot be equated across conditions. Using parametric modulation analysis, we investigated the effect of occurrence probability of imagined future events on brain activation patterns, while effects of temporal distance, amount of details, and emotionality were controlled for. Activation of right anterior hippocampus increased with decreasing occurrence probability, presumably reflecting higher processing demands during binding of more disparate details for unlikely events. This finding may contribute to the understanding of previously reported inconsistent results concerning hippocampal involvement during the imagination of past and future events. © 2009 Wiley‐Liss, Inc.
Performance Analysis of Long Range Prediction for Fast Fading Channels 1

(cid:150) Long range prediction capability for fading channels would provide enabling technology for accurate power control, reliable transmitter and/or receiver diversity, more effective adaptive modulation and coding and improvements in many other components of wireless systems. In order to achieve accurate long range prediction, the authors recently introduced a novel algorithm that finds the linear Minimum Mean Squared Error (MMSE) estimate of the future fading coefficient given a fixed number of previous observations. In this paper, we show that the superior performance of this algorithm is due to its lower sampling rate relative to the conventional (data rate) methods of fading estimation. We present the theoretical analysis of the MMSE of long range prediction as a function of several parameters: the number of scatterers, model order, sampling rate and the Signal-to-Noise ratio (SNR). Moreover, we show that the long range prediction can be further improved by employing adaptive tracking combined with the truncated channel inversion algorithm.
Life Expectancy of Patients With Chronic Myeloid Leukemia Approaches the Life Expectancy of the General Population.

PURPOSE A dramatic improvement in the survival of patients with chronic myeloid leukemia (CML) occurred after the introduction of imatinib mesylate, the first tyrosine kinase inhibitor (TKI). We assessed how these changes affected the life expectancy of patients with CML and life-years lost as a result of CML between 1973 and 2013 in Sweden. MATERIALS AND METHODS Patients recorded as having CML in the Swedish Cancer Registry from 1973 to 2013 were included in the study and followed until death, censorship, or end of follow-up. The life expectancy and loss in expectation of life were predicted from a flexible parametric relative survival model. RESULTS A total of 2,662 patients with CML were diagnosed between 1973 and 2013. Vast improvements in the life expectancy of these patients were seen over the study period; larger improvements were seen in the youngest ages. The great improvements in life expectancy translated into great reductions in the loss in expectation of life. Patients of all ages diagnosed in 2013 will, on average, lose < 3 life-years as a result of CML. CONCLUSION Imatinib mesylate and new TKIs along with allogeneic stem cell transplantation and other factors have contributed to the life expectancy in patients with CML approaching that of the general population today. This will be an important message to convey to patients to understand the impact of a CML diagnosis on their life. In addition, the increasing prevalence of patients with CML will have a great effect on future health care costs as long as continuous TKI treatment is required.
Design of a heterotetrameric coiled coil

We have successfully designed a simple peptide sequence that forms highly stable coiled‐coil heterotetramers. Our model system is based on the GCN4‐pLI parallel coiled‐coil tetramer, first described by Kim and coworkers (Harbury et al., Science 1993;262:1401–1407). We introduced glutamates at all of the e and c heptad positions of one sequence (ecE) and lysines at the same positions in a second sequence (ecK). Based on a modeling study, these sidechains are close enough in space to form structure‐stabilizing salt bridges. We show that ecE and ecK are highly unstable by themselves but form very stable parallel helical tetramers when mixed, as judged by circular dichroism, analytical ultracentrifugation, and disulfide crosslinking studies. The origin of the difference in stabilities between the homomeric structures and the heteromeric structures comes from a combination of the relief of electrostatic repulsions with concomitant formation of electrostatic attractive interactions based on pH and NaCl screening experiments. We quantify the stability of the heterotetrameric coiled coil from a thermodynamic analysis and compare the finding to other similar coiled‐coil systems.
Virological and histological features of hepatitis C virus (HCV) infection in kidney transplant recipients.

BACKGROUND Although there are some reports regarding prevalence of anti-HCV antibodies in kidney transplant patients, there are scarce data about viraemia, genotyping and liver histology of HCV infection in kidney transplant recipients. METHODS We studied the prevalence of anti-HCV antibodies by second-generation screening and confirmatory assays in a cohort of 73 renal allograft recipients. All patients were tested for serum HCV RNA using reverse transcription polymerase chain reaction in the 5'-untranslated region (UTR) of the viral genome. HCV RNA positive patients were subjected to genotype analysis using biotinylated type-specific oligonucleotide probes after hybridization with amplified sample material. Eleven of 73 patients showing raised aminotransferase levels underwent hepatic biopsy. RESULTS Fifteen of 73 (20%) patients were determined anti-HCV positive. Eleven of 73 (15%) showed detectable serum HCV RNA; no viraemic, seronegative patients were identified. Genotyping showed that HCV subtype 2a was dominant (64%), followed by HCV subtypes 1b (27%) and 1a (9%). Six of 11 (54%) HCV RNA patients and 12 of 62 (19%) HCV RNA negative patients showed raised aminotransferase levels (P = 0.03). Liver biopsies showed histological features of chronic hepatitis with mild or moderate degrees of activity. CONCLUSIONS The prevalence of anti-HCV antibodies and HCV viraemia was 20% and 15% respectively; there was a good association between anti-HCV anti-bodies and HCV viraemia; hepatic enzyme levels were good indicators of ongoing HCV infection; HCV subtype 2a was prevalent; liver histology showed histological characteristics of chronic hepatitis with mild or moderate degrees of activity.
Time, Oral Tradition, and Archaeology at Xakwnoowú, A Little Ice Age Fort in Southeastern Alaska

Abstract As a linguistic medium, oral tradition conveys rich and specific detail about past events but is also subject to alteration in the course of transmission between generations. As a source for indigenous history, spoken heritage is characteristically specific in geographic attribution and thus definitive of cultural landscapes, but it is temporally under-defined because it is unconstrained by calendrical dates. We consider these qualities in relation to Tlingit oral accounts that refer to Xak-wnoowú, an 850-year-old fort in the Glacier Bay region of southeastern Alaska. The site is narratively linked to the origins of Tlingit warfare and of the Kaagwaantaan clan, and remains a landmark of historical consciousness for contemporary descendants. We apply archaeological and geological evidence to date and verify key oral narratives, finding substantial convergence with scientific data and a complementarity of perspective that potentiates fuller understandings of both Tlingit history and environmental change during the Little Ice Age. We conclude that the historicity of oral tradition—a topic of wide current debate—is clearly demonstrated at Xakwnoowú, although instances of chronological compression are revealed by the analysis.
The Wadi Khashab ceremonial complex — a manifestation of cattle keepers in the Eastern Desert of Egypt before the end of the fifth millennium BC

ABSTRACT Despite suggestions of cattle keepers being present in the Eastern Desert of Egypt before the end of the fifth millennium BC there is still no archaeological evidence concerning settlement patterns and relations to the cultures of the Nile and Western Desert. Archaeozoological datasets have also been lacking for ancient herding models and animal metrics/morphology in the region. Research at Wadi Khashab provides new data with which to address these questions. Analysis of complete skeletons of cattle and sheep buried under stone mounds and fenced with symbolic zeriba (kraals) shows osteological features that refer to the animal’s behaviour and life-long migration in harsh environmental conditions. Applying the point-scale statistical method for osteometric values allows the Wadi Khashab animals to be compared with numerous ancient animal populations from the Nile Valley. The metrically most similar animals were those kept by the Bronze Age Kerma Culture of Nubia. The spatial relations of the site elements at Wadi Khashab — including the animal/human cemetery and megalithic installations that are set out along a southeast-northwest axis — allow us to suppose the simultaneous creation of the sacral complex there before the end of the fifth millennium BC. The site appears to have been plundered in the following millennium and a pottery find suggests another episode of human presence in the first half of the second millennium BC.
Association of pyoderma gangrenosum and sterile osteomyelitis in a patient having myelodysplastic syndrome with der(1;7)(q10;q10)

Neutrophilic dermatoses such as Sweet's disease and pyoderma gangrenosum (PG) are occasionally associated with myelodysplastic syndrome (MDS). We present here a 67‐yr‐old male having PG and sterile osteomyelitis in association with underlying MDS (refractory anemia) and Crohn's disease. To establish the diagnosis of MDS, sternal bone marrow puncture was performed, which showed chromosomal abnormality containing der(1;7)(q10;q10). After the puncture, he suffered from gradually progressive skin ulceration, flare, and bone pain. Magnetic resonance imaging (MRI) of the sternum showed severe inflammation in the sternum and the overlying subcutaneous tissue. All of the cultures obtained from the wound were negative for both bacteria and fungus. Biopsy was performed from the antero‐sternal skin lesion, which showed epidermal ulceration with prominent infiltration of neutrophils. He was thus diagnosed as having PG and sterile osteomyelitis, and was treated with prednisolone, which completely resolved the symptoms. We consider that the bone marrow aspiration in the present patient provoked PG and sterile osteomyelitis. As was previously reported by others, certain chromosomal abnormalities in MDS may be related with the development of neutrophilic dermatoses.
Immunohistochemistry of the lymphoid tissues of the tammar wallaby, Macropus eugenii

The lymphoid tissues of the metatherian mammal, the adult tammar wallaby, Macropus eugenii, were investigated using immunohistochemical techniques. Five cross‐reactive antibodies previously shown to recognize surface markers in marsupial tissues and five previously untested antibodies were used. The distribution of T‐cells in the tissue beds of spleen, lymph node, thymus, gut‐associated lymphoid tissue (GALT) and bronchus‐associated lymphoid tissue (BALT) was documented using antibodies to CD3 and CD5. Similarly, B‐cells were identified in the same tissues using anti‐CD79b. Antibodies to CD8, CD31, CD79a and CD68 failed to recognize cells in these tissue beds. In general the pattern of cellular distribution identified using these antibodies was similar to that observed in other marsupial and eutherian lymphoid tissues. This study provides further information on the commonality of lymphoid tissue structure in the two major groups of extant mammals, metatherians and eutherians.
Expression of Putative Sex-Determining Genes during the Thermosensitive Period of Gonad Development in the Snapping Turtle, Chelydra serpentina

Modes of sex determination are quite variable in vertebrates. The developmental decision to form a testis or an ovary can be influenced by one gene, several genes, environmental variables, or a combination of these factors. Nevertheless, certain morphogenetic aspects of sex determination appear to be conserved in amniotes. Here we clone fragments of nine candidate sex-determining genes from the snapping turtle Chelydra serpentina, a species with temperature-dependent sex determination (TSD). We then analyze expression of these genes during the thermosensitive period of gonad development. In particular, we compare gene expression profiles in gonads from embryos incubated at a male-producing temperature to those from embryos at a female-producing temperature. Expression of Dmrt1 and Sox9 mRNA increased gradually at the male-producing temperature, but was suppressed at the female-producing temperature. This finding suggests that Dmrt1 and Sox9 play a role in testis development. In contrast, expression of aromatase, androgen receptor (Ar), and Foxl2 mRNA was constant at the male-producing temperature, but increased several-fold in embryos at the female-producing temperature. Aromatase, Ar, and Foxl2 may therefore play a role in ovary development. In addition, there was a small temperature effect on ERα expression with lower mRNA levels found in embryos at the female-producing temperature. Finally, Dax1, Fgf9, and SF-1 were not differentially expressed during the sex-determining period, suggesting these genes are not involved in sex determination in the snapping turtle. Comparison of gene expression profiles among amniotes indicates that Dmrt1 and Sox9 are part of a core testis-determining pathway and that Ar, aromatase, ERα, and Foxl2 are part of a core ovary-determining pathway.
Phospholipase C Rescues Visual Defect in norpA Mutant of Drosophila melanogaster(*)

Mutations in the norpA gene of Drosophila melanogaster severely affect the light-evoked photoreceptor potential with strong mutations rendering the fly blind. The norpA gene has been proposed to encode phosphatidylinositol-specific phospholipase C (PLC), which enzymes play a pivotal role in one of the largest classes of signaling pathways known. A chimeric norpA minigene was constructed by placing the norpA cDNA behind an R1-6 photoreceptor cell-specific rhodopsin promoter. This minigene was transferred into norpA mutant by P-element-mediated germline transformation to determine whether it could rescue the phototransduction defect concomitant with restoring PLC activity. Western blots of head homogenates stained with norpA antiserum show that norpA protein is restored in heads of transformed mutants. Moreover, transformants exhibit a large amount of measurable PLC activity in heads, whereas heads of norpA mutant exhibit very little to none. Immunohistochemical staining of tissue sections using norpA antiserum confirm that expression of norpA protein in transformants localizes in the retina, more specifically in rhabdomeres of R1-6 photoreceptor cells, but not R7 or R8 photoreceptor cells. Furthermore, electrophysiological analyses reveal that transformants exhibit a restoration of light-evoked photoreceptor responses in R1-6 photoreceptor cells, but not in R7 or R8 photoreceptor cells. This is the strongest evidence thus far supporting the hypothesis that the norpA gene encodes phospholipase C that is utilized in phototransduction.
Weight gain in antipsychotic-naive patients: a review and meta-analysis

Background Weight gain is a long-recognized side-effect of antipsychotic (AP) drugs and a major health concern in the treatment of psychosis. The strength of the causal relationship between AP drug exposure and weight gain can only be gauged by a drugs trial conducted on AP-naive patients. Method We conducted a review of the literature regarding the amount of weight gain induced by APs in AP-naive patients and carried out a meta-analysis of mean weight gains. Results We found 11 primary studies reporting the effects of APs on body weight or body mass index (BMI) in AP-naive patients. The mean body weight and BMI gains in AP-naive patients were highly significant from the first weeks of treatment. When we limited the analysis to studies conducted on patients hospitalized and without any adjunctive treatment potentially affecting weight, the resultant sample showed less heterogeneity and confirmed the final picture of weight gain at around 3.8 kg and 1.2 points BMI. Conclusions Weight gain associated with AP therapy in AP-naive patients occurs rapidly in the first few weeks and continues during the following months. Clinicians should be aware of the high probability of causing weight gain in AP-naive patients and should strictly monitor such patients.
Well-Being and Older People: A Review of the Literature

Background. Most countries in the world are experiencing an expansion in their population of older people. As people now expect to live longer, they also seek continuing health and well-being throughout their extended old age. Occupational therapists are involved in working towards the attainment of well-being with their older clients. However, their understandings of what well-being for older people entails seems varied, as this examination of the occupational therapy and related gerontological literature reveals. Results. Three key points emerge from the literature review: first, the definition of well-being is usually assumed, or is lacking in clarity, and a range of similar terms, such as happiness and life satisfaction, are used interchangeably; second, well-being has been measured in research using various scales, which may not capture the complexity of the concept; and third, the perspective of the older person is often missing in discussions of well-being. Clinical Implications. It is suggested that one way of moving occupational therapists' understanding of well-being forward is to conduct research into what older people themselves understand or perceive well-being to be.
Management of patellofemoral problems.

Patellofemoral pain is often a challenge for the physiotherapist, because of its complex aetiology. Physiotherapists with their understanding of soft tissue structure and muscle function are well positioned to effectively manage most patellofemoral problems by improving the extensibility and mobility of tight structures and improving the timing of the elongated muscles. This will involve recognising the biomechanical factors contributing to the symptoms, adequately explaining to the patient the cause of the symptoms and teaching the patient how to manage the symptoms. Specific training of certain muscles with accurate feedback to change the timing of these muscles during functional and sporting activities will be required if this problem is not to recur.
Vascular endothelial growth factor expression in preoperative biopsy specimens correlates with disease recurrence in patients with early gastric carcinoma

Recently many studies have demonstrated that the degree of tumor angiogenesis is related to the aggressiveness of the tumor and clinical outcome. Vascular endothelial growth factor (VEGF) is a well characterized inducer of angiogenesis. In this study, the authors investigated the prognostic significance of VEGF expression in patients with early gastric carcinoma together with p53 gene abnormality and tumor cell proliferation.
Intrarenal Mas and AT1 receptors play a role in mediating the excretory actions of renal interstitial angiotensin‐(1–7) infusion in anaesthetized rats

What is the central question of this study? Dietary sodium manipulation alters the magnitude of angiotensin‐(1–7) [Ang‐(1–7)]‐induced natriuresis. The present study sought to determine whether this was related to relative changes in the activity of intrarenal Mas and/or AT1 receptors. What is the main finding and its importance? Angiotensin‐(1–7)‐induced diuresis and natriuresis is mediated by intrarenal Mas receptors. However, intrarenal AT1 receptor blockade also had an inhibitory effect on Ang‐(1–7)‐induced natriuresis and diuresis. Thus, Ang‐(1–7)‐induced increases in sodium and water excretion are dependent upon functional Mas and AT1 receptors.
The earlier the colonization by mutans streptococci, the higher the caries prevalence at 4 years of age.

Seventy-eight 4-year-old children, examined earlier for the presence of mutans streptococci at 4-month intervals from 15 months of age, were recalled for recording of dental caries and salivary sampling. The saliva samples were analysed for the presence of mutans streptococci, including the species Streptococcus mutans and Streptococcus sobrinus and lactobacilli. The results showed that the earlier the mutans streptococci had been detected in the children, the higher the caries experience. Eighty-nine percent of the children colonized at 2 years of age had experienced caries and had a mean dfs of 5.0 compared with 25% of the non-colonized 4-year-olds with a mean dfs of 0.3. S. mutans was the predominant species. S. sobrinus was usually found in combination with S. mutans, except in 2 children where S. sobrinus was the only species detected. More children with multiple species had higher numbers of total mutans streptococci and a tendency to higher caries prevalence than children with only S. mutans.