Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessment of Patients with Coronary Artery Diseases Need to Discharge Plan regarding to Living and Home Arrangement at Babylon Teaching Hospitals

Background: Coronary artery disease is one of the most serious diseases affecting human health, leading to more disability, economic cost and death (Hussein. 2014). Implementing the discharge plan from the health personals in the hospital correctly is to reduce the patient's long stay in the hospital also to improve the coordination of services after the discharge to home and reduce the frequency of admission to the hospital (Shepperd, ET .al. 2013). Objective: To assess the needs of patients with coronary artery disease for discharge plan related to living arrangement and home activities. Method and Results: Descriptive- cross sectional design selected to carry out this study, two Babylon Teaching Hospitals used to collect the study from the period between 1 Sep. 2016 to 1 Sep. 2017.Non- probability purposive sample of (100) patients who admitted to the Coronary Care units or medical ward were selected to participated in the study. Special questionnaire prepared after comprehensive literature review, face-to-face interview used as a method to collect the data. The statistical results shows that the majority (65%) of the study sample were male, (64%)were 60 or above 60 years old, (41%) were illiterate, most of the sample (34%) were retired, related to the living arrangement and home activities they recorded poor responses regarding most items. Conclusion: Significant need poor related to home and living arrangement discharge plan for patients with coronary artery disease. Which need health team intervention? Poor responses recorded by the patients with coronary artery disease, significant need to structured discharge plan related to living arrangement and home activities clearly appears. Significant need, poor responses recorded by the patient with coronary artery disease related living and home arrangement. Recommendation: Special discharge plan may take place to cover the patients need and increase their knowledge related to the home activities and living arrangement, which enhance life style and reduce expected complication. Keywords: Discharge plan, Coronary artery disease, Living and home arrangement.
Nuclear actin regulates inducible transcription by enhancing RNA polymerase II clustering

Nuclear actin promotes the formation of inducible transcription factory, as a general mechanism of the rapid response to stimuli. Gene expression in response to stimuli underlies many fundamental processes. However, how transcription is regulated under these scenarios is largely unknown. Here, we find a previously unknown role of nuclear actin in transcriptional regulation. The RNA-seq data reveal that nuclear actin is required for the serum-induced transcriptional program. Using super-resolution imaging, we found a remarkable enhancement of RNA polymerase II (Pol II) clustering upon serum stimulation, and this enhancement requires nuclear actin. Pol II clusters colocalized with the serum-response genes and nuclear actin filaments upon serum stimulation. Furthermore, N-WASP is required for serum-enhanced Pol II clustering. N-WASP phase-separated with Pol II and nuclear actin. In addition to serum stimulation, nuclear actin also enhanced Pol II clustering upon interferon-γ treatment. Together, our work unveils that nuclear actin promotes the formation of transcription factory on inducible genes, acting as a general mechanism underlying the rapid response to environmental cues.
Storage Behavior of Juice Prepared from Nagpur Mandarin Orange (Citrus reticulata)

The present investigation was carried out during 2015–2016 at Post Harvest Technology Centre, Department of Horticulture, Mahatma Phule Krishi Vidyapeeth, Rahuri. The storage behavior of juice extracted by screw type pulper using different preservative levels packed in different packaging materials and stored at ambient and cold storage was studied. The data regarding chemical composition revealed that there was increase in TSS, acidity, total sugars, reducing sugars while pH, ascorbic acid, decreased in all treatment combination of juice during 180d of storage. The sensory scores viz., colour, flavour, taste and overall acceptability of juice during 180d of storage was decreased in all treatment combination. The microbial quality viz., yeast and mould count were found to be increased during 180d of storage. The microbial growth was observed within acceptable level in all treatment combination of juice stored in cold storage and 350 ppm sodium benzoate treated juice packed in glass bottle stored in ambient conditions (T7). The Nagpur mandarin juice could be stored for 180d at cold storage (5±2°C) by using 350ppm sodium benzoate packed in glass bottles (T16, S2P3B1) followed by juice packed in PET bottles (T17, S2P3B2) was found to be superior in respect of chemical composition, sensory evolution and microbial quality.
Administration of nucleotides in poultry diet: Effect on the lipid composition of the Pectoralis major muscle

1 Faculty of Veterinary Medicine/Department of Morphology, Physiology, Biochemistry and Animal Production, University of Messina, Polo Universitario Annunziata, 98168 Messina, Italy; 2 Consortium of Meat Research, Polo Universitario Annunziata, 98168 Messina, Italy; 3 Faculty of Veterinary Medicine/Department of Veterinary Sciences and Technologies for Food Safety, University of Milan, Via Celoria, 10, 20133 Milan, Italy. *Corresponding author: biagina.chiofalo@unime.it
Degradation of Dicamba, Picloram, and Four Phenoxy Herbicides in Soils

The degradation rates of 2,4-D [(2,4-dichlorophenoxy)acetic acid], dichlorprop [2-(2,4-dichlorophenoxy)propionic acid], 2,4,5-T [(2,4,5-trichlorophenoxy)acetic acid], silvex [2,(2,4,5-trichlorophenoxy)propionic acid], dicamba (3,6-dichloro-o-anisic acid), and picloram (4-amino-3,5,6-trichloropicolinic acid) were determined in three soils. Herbicide breakdown was proportional to herbicide concentration, so half life of the various herbicides was calculated from linear regression of the logarithm transformed residue data. The average half life for 2,4-D, dichlorprop, silvex, 2,4,5-T, dicamba, and picloram were, respectively, 4 days, 10 days, 17 days, 20 days, 25 days, and greater than 100 days. The rate of degradation of 2,4-D was the same in all three soils, but for the other herbicides it was consistently faster in soil removed from under grass vegetation than from under trees.
Phase II study of avelumab in multiple relapsed/refractory testicular germ cell cancer.

e16045 Background: Testicular germ cell tumors (TGCTs) represent a highly curable disease; however, a small proportion of patients develop disease recurrence. PD-L1 expression is significantly higher in germ cell tumors (GCTs) in comparison to normal testicular tissue and high PD-L1 expression is associated with inferior progression-free and overall survival compared to patients with low PD-L1 expression. This study aimed to determine the efficacy and toxicity of PD-L1 antagonist, Avelumab, in patients with refractory GCTs. Methods: From November 2017 to January 2018, 8 patients with refractory GCTs were enrolled in the phase II study. All patients were pretreated with at least 2 cisplatin-based therapies (median 5, range 2 – 6); 5 tumors (62.5%) were absolutely refractory to cisplatin and 5 patients (62.5%) had visceral non-pulmonary metastases. Avelumab was administered at a dose of 10mg/kg biweekly until progression or unacceptable toxicity. The primary end point was 12-weeks progression-free survival (PFS). If < 8 responses to study therapy will be observed among the first 15 patients, the study will be terminated. Results: Median age was 29 years (range: 22 – 52 years). During a median follow-up period of 2.6 months (range: 0.3 - 14.4), 7 (87.5%) patients experienced disease progression and 6 patients (80.0%) died. Twelve-week PFS was 0%, median PFS was 1.4 months, 95%CI (0.9 – 1.4) and median OS was 2.7 months, 95% CI (1.0 – 3.3). No objective response was observed. Avelumab was well tolerated, no severe adverse event was observed. Conclusions: This study failed to achieve its primary end point and our data suggest lack of Avelumab efficacy in unselected multiple relapsed/refractory TGCTs. Clinical trial information: NCT03403777.
BIOMARKERS OF DISEASES: AN EVIDENCE-BASED APPROACH

Evidence-based medicine (EBM) challenges clinicians and laboratory professionals to make rational decisions in healthcare. The most common definition of EBM comes from Dr. David Sackett. EBM is »the conscientious, explicit and judicious use of current best evidence in making decisions about the care of the individual patient. It means integrating individual clinical expertise with the best available external clinical evidence from systematic research« (1).
A high speed serializer/deserializer design

A Serializer/Deserializer (SerDes) is a circuit that converts parallel data into a serial stream and vice versa. It helps solve clock/data skew problems, simplifies data transmission, lowers the power consumption and reduces the chip cost. The goal of this project was to solve the challenges in high speed SerDes design, which included the low jitter design, wide bandwidth design and low power design. A quarter-rate multiplexer/demultiplexer (MUX/DEMUX) was implemented. This quarter-rate structure decreases the required clock frequency from one half to one quarter of the data rate. It is shown that this significantly relaxes the design of the VCO at high speed and achieves lower power consumption. A novel multi-phase LC-ring oscillator was developed to supply a low noise clock to the SerDes. This proposed VCO combined an LC-tank with a ring structure to achieve both wide tuning range (11%) and low phase noise (-110dBc/Hz at 1MHz offset). With this structure, a data rate of 36 Gb/s was realized with a measured peak-to-peak jitter of 10ps using 0.18microm SiGe BiCMOS technology. The power consumption is 3.6W with 3.4V power supply voltage. At a 60 Gb/s data rate the simulated peak-to-peak jitter was 4.8ps using 65nm CMOS technology. The power consumption is 92mW with 2V power supply voltage. A time-to-digital (TDC) calibration circuit was designed to compensate for the phase mismatches among the multiple phases of the PLL clock using a three dimensional fully depleted silicon on insulator (3D FDSOI) CMOS process. The 3D process separated the analog PLL portion from the digital calibration portion into different tiers. This eliminated the noise coupling through the common substrate in the 2D process. Mismatches caused by the vertical tier-to-tier interconnections and the temperature influence in the 3D process were attenuated by the proposed calibration circuit. The design strategy and circuits developed from this dissertation provide significant benefit to both wired and wireless applications.
Self-sterility May Be Due to Prezygotic Late-acting Self-incompatibility and Early-acting Inbreeding Depression in Chinese Chestnut

Chinese chestnut (Castanea mollissima), which is native to China, has been cultivated as a nontimber forest tree species for 4000 years. This species has been found to display self-sterility, which results in a significantly lower seed set following self-pollination (SP) compared with that following cross-pollination (CP). Self-sterility can be induced by prezygotic or postzygotic late-acting self-incompatibility (LSI) or early-acting inbreeding depression (EID). To elucidate the causes of self-sterility in chestnut, we investigated pollen–pistil interactions, fertilization, and early ovule development following SP and CP by using a paraffin section technique and fluorescence microscopy. The fruit set percentage and seed characteristics also were evaluated among different pollination treatments. The results show that there were no significant differences in pollen tube behavior following SP vs. CP, regardless of the stigmatic or stylar level. Double fertilization was significantly greater following CP (18.09%) than SP (2.58%). The significantly lower percentages of ovule penetration and double fertilization in the selfed vs. crossed ovules support a prezygotic LSI mechanism in C. mollissima. The fruit set resulting from chase-pollination (CHP; 53.85% to 63.64%) was greater than that resulting from SP (12.12% to 14.00%). In addition, the distribution of aborted seed sizes after SP showed a widely clumped pattern. Abortion occurred at different stages during seed development rather than at a uniform stage, which supported the idea that EID was operating in C. mollissima. Levels of self-sterility in the chinese chestnut trees ranged from 88.2% to 90.5%. Thus, partial prezygotic LSI and EID contributed to self-sterility in the C. mollissima ‘Yanshanzaofeng’, with prezygotic LSI rejecting part of the self-pollen in the ovary and EID aborting part of the self-fertilized seeds.
Clinical biomechanics of the lower extremities

Clinical Biomechanics of the Lower Extremity is a comprehensive text addressing the principles of anatomic and biomechanical development and the clinical application of these principles to disease/disorder management. The emphasis of the book is on practical information applicable to the daily practice of lower extremity care. Topics covered include: the physical examination and the assessment of disorders having a biomechanical basis, casting techniques, prescription writing, orthotic trouble-shooting, splinting and shoe prescription for athletic activity.
Impaired Social Learning Predicts Reduced Real-life Motivation in Individuals with Depression: A Computational fMRI Study

Background Major depressive disorder is associated with altered social functioning and impaired learning, on both the behavioural and the neural level. These deficits are likely related, considering that successful social interactions require learning to predict other people’s emotional responses. Yet, there is little research examining this relation. Methods Forty-three individuals with high (HD; N=21) and low (LD; N=22) depression scores answered questions regarding their real-life social experiences and performed a social learning task during fMRI scanning. As part of the task, subjects learned associations between name cues and rewarding (happy faces) or aversive (fearful faces) social outcomes. Using computational modelling, behavioural and neural correlates of social learning were examined and related to real-life social experiences. Results HD participants reported reduced motivation to engage in real-life social activities and demonstrated elevated uncertainty about social outcomes in the task. Moreover, HD subjects displayed altered encoding of social reward predictions in the insula, temporal lobe and parietal lobe. Interestingly, across all subjects, higher task uncertainty and reduced parietal prediction encoding were associated with decreased motivation to engage in real-life social activities. Limitations The size of the included sample was relatively small. The results should thus be regarded as preliminary and replications in larger samples are called for. Conclusion Taken together, our findings suggest that reduced learning from social outcomes may impair depressed individuals’ ability to predict other people’s responses in real life, which renders social situations uncertain. This uncertainty, in turn, may contribute to reduced social engagement (motivation) in depression.
An updated review on phytopharmacological profile of Euphorbia tithymaloides (L.) Poit

Euphorbia tithymaloides (L.) Poit or Pedilanthus tithymaloides, (Family: Euphorbiaceae), is a tropical and subtropical succulent plant. This plant is available in various parts of India: Assam, Bihar, Gujarat, Madhya Pradesh, Maharashtra, Odisha, and Uttar Pradesh. The stem of this plant has morphological resemblance with spinal column due to zigzag structure. The fleshy tubular stems of this plant are thin pencil like which produce thick, dark-green or variegated, fleshy, ovate leaves and peculiar beak shaped flowers. Pedilanthus tithymaloides is mostly used as an ornamental plant and for making fencing in garden. It is latex producing plant and its latex has been traditionally used to treat various pathological conditions apart from latex its leaves, stem and roots also used to treat ear ache, insect stings, ringworm, skin cancer, toothache, umbilical hernias, and warts. This plant is reported to possess various phytochemicals viz. steroids, tannins, triterpenes, coumarins and saponins which have been shown to possess anti-diabetic, antioxidant, analgesic, stomachic, hemostatic, anti-microbial, antifungal, antihelminthic, antimutagenic, anti-tubercular, antimalarial, anti-inflammatory, abortifacient, antivenom, antibiotic, antiseptic, antihemorrhagic, antiviral and antitumor effect and useful for venereal diseases. The isolated phytochemicals reported in this plant were cycloartenone, dammaronol A, dotriacontan1ol, friedelanol, hentriacontan-1-ol and sitosterol. Some of the antioxidant principles like Kaempferol, quercitrin, isoquercitrin, and scopoletin were isolated. The significant bioactive principles reported in Pedilanthus tithymaloides were diterpenoids, triterpene, flavonoids, carotenoids, pedilanthus coumarin A, pedilanthus coumarin B, 5,7-dihydroxy-8-(2-methylbutyryl)-4-phenylcournarin, theraphin C, isodispar B, isodisparinol B and isomesuol. Recently silver nanoparticles of plant latex have been synthesized for their potential use as antibacterial agents. The aim of present review is an effort to provide coherent literature survey of plant Euphorbia tithymaloides or Pedilanthus tithymaloides in relation to its phytopharmacological, ethnobotanical and therapeutical uses that would pave the way for development of phytopharmaceuticals.
Phase Ib study of MIW815 (ADU-S100) in combination with spartalizumab (PDR001) in patients (pts) with advanced/metastatic solid tumors or lymphomas.

2507 Background: MIW815 (ADU-S100) is a novel synthetic cyclic dinucleotide that activates the STimulator of INterferon Genes (STING) pathway impacting tumor cells, tumor microenvironment, vasculature, tumor-associated fibroblasts, and priming APC and CD8+ T cells. Spartalizumab is a humanized IgG4 mAb that blocks the binding of PD-1 to PD-L1/2. Preclinical data support synergistic antitumor effects when MIW815 (ADU-S100) is combined with checkpoint inhibitors. Methods: In this Phase Ib dose escalation study, pts with advanced/metastatic solid tumors or lymphoma received MIW815 (ADU-S100) (intratumoral injections [50–800 µg] either weekly [3 weeks on/1 week off] or Q4W) and spartalizumab (400 mg IV Q4W). Injected and non-injected tumor biopsies were obtained at baseline and on treatment. Primary objectives are to determine safety and identify a dose/schedule for future studies. Preliminary activity, pharmacokinetics (PK), and pharmacodynamics (PD) are also being explored. Results: As of Jan 11, 2019, 66 pts (median age: 61 y) with various solid tumors or lymphomas have been treated. Treatment was discontinued in 49 pts (74%) due to disease progression (n = 28), pt/physician decision (n = 18), AE (n = 2), or death (n = 1). No DLTs were reported during the first cycle at any dose level. Most common (≥5 pts) treatment-related AEs (TRAEs) were injection site pain (12%), pyrexia (11%), and diarrhea (9%). Grade 3/4 TRAEs (in ≥2 pts) were increased AST and ALT (3% each). Serious TRAEs were pyrexia (3%), increased amylase, increased lipase, diarrhea, fatigue, hyperthyroidism, partial seizures, dyspnea, and pneumonitis (all 2%). Partial responses in pts with PD-1–naive TNBC and PD-1–relapsed/refractory melanoma have been observed. MIW815 (ADU-S100) plasma exposure generally increased in a dose-dependent manner with a rapid terminal half-life. Response data, PK and PD analyses will be presented. Conclusions: Thus far, MIW815 (ADU-S100) + spartalizumab has demonstrated antitumor activity in PD-1–naive TNBC and PD-1–relapsed/refractory melanoma. The combination is well tolerated, with no DLTs reported to date. The MTD has not been reached and dose escalation is ongoing. Clinical trial information: NCT03172936.
Mitochondrial Genome Diversity in the Central Siberian Plateau with Particular Reference to Prehistory of Northernmost Eurasia

The Central Siberian Plateau was last geographic area in Eurasia to become habitable by modern humans after the Last Glacial Maximum (LGM). Through comprehensive mitochondrial DNA genomes retained in indigenous Siberian populations, the Ket, Tofalar, and Todzhi - we explored genetic links between the Yenisei-Sayan region and Northeast Eurasia over the last 10,000 years. Accordingly, we generated 218 new complete mtDNA sequences and placed them into compound phylogenies along with 7 newly obtained and 70 published ancient mt genomes. Our findings reflect the origins and expansion history of mtDNA lineages that evolved in South-Central Siberia, as well as multiple phases of connections between this region and distant parts of Eurasia. Our result illustrates the importance of jointly sampling modern and prehistoric specimens to fully measure the past genetic diversity and to reconstruct the process of peopling of the high latitudes of the Siberian subcontinent.
A prospective observational study involving three fixed infusion regimens of phenylephrine for hemodynamic support during spinal anaesthesia for caesarian delivery

Background: Spinal anaesthesia used in caesarian section is associated with hypotension which can have maternal and fetal side effects. To determine the efficacy and ideal dosing of Phenylephrine in attenuating the hypotensive episodes during caesarean section under spinal anaesthesia.Methods: 100 patients were allocated to four groups, placebo group (PE 0) and 3 fixed phenylephrine infusion regimens, phenylephrine 25 μg/min-1 (PE 25), phenylephrine 50 μg/min-1 (PE 50), and phenylephrine 75 μg/min-1 (PE 75). Blood pressure, heart rate were noted among primary variables and fetal parameters like umbilical blood pH and lactate were recorded as secondary parameters.Results: There was a significant reduction in heart rate with increasing the infusion dosage of phenylephrine, with a mean of 86.8 beats/min at the end of procedure in placebo group and 69.4 beats/min in 75 μg group (p value <0.001). There was significant statistical difference among systolic blood pressure in the four groups after 7 min of the procedure and p-value of <0.05 with better attenuation of hypotension in infusion groups as compared to placebo. Similarly there was significant statistical difference in diastolic blood pressure among the four groups after 8 min of the procedure with p values <0.05. Conclusions: Prophylactic phenylephrine infusions reduced the incidence and severity of maternal pre-delivery hypotension. Among the fixed rate phenylephrine infusion regimens investigated, infusion rates of 50 μg/min-1 were associated with greater maternal hemodynamic stability compared with 25 and 75 μg/min-1, with minimal side effects and intervention.