Miracle-dz/UniFAR-FTUs huggingface dataset:
Nucleolar KKE/D repeat proteins Nop56p and Nop58p interact with Nop1p and are required for ribosome biogenesis

Different point mutations in the nucleolar protein fibrillarin (Nop1p in Saccharomyces cerevisiae) can inhibit different steps in ribosome synthesis. A screen for mutations that are synthetically lethal (sl) with the nop1-5 allele, which inhibits pre-rRNA processing, identified NOP56. An independent sl mutation screen with nop1-3, which inhibits pre-rRNA methylation, identified a mutation in NOP58. Strikingly, Nop56p and Nop58p are highly homologous (45% identity). Both proteins were found to be essential and localized to the nucleolus. A temperature-sensitive lethal mutant allele, nop56-2, inhibited many steps in pre-rRNA processing, particularly on the pathway of 25S/5.8S rRNA synthesis, and led to defects in 60S subunit assembly. Epitope-tagged constructs show that both Nop56p and Nop58p are associated with Noplp in complexes, Nop56p and Nop1p exhibiting a stoichiometric association. These physical interactions presumably underlie the observed sl phenotypes. Well-conserved homologs are present in a range of organisms, including humans (52% identity between human hNop56p and yeast Nop56p), suggesting that these complexes have been conserved in evolution.
On the Development of Sport in Promoting the Role of Cities

Based on the sport as a significant influence of the time,the potential of unlimited increase in the industry,pro and social media and interpersonal communication as a positive realization and practice of modern way of life,expounded the current levels of various cities in the world to use sport to promote urban development,the main practical effect the pursuit of nine areas: 1 upgrade the city′s global influence;2 reshape city image;3 for urban regeneration;4 led the city in transition;5 to create tourist destinations;6 for the City Sports Industry Cluster or functional area of formation and development;7 to increase employment;8 to attract investment and talent;9 to improve the quality of life of residents.
Measuring the Cash Conversion Cycle in an International Supply Chain 1

The Cash Conversion Cycle (C2C) is a powerful performance metric for assessing how well a company is managing capital. A company with a lower C2C is more efficient because it turns its working capital over more times per year, and that allows it to generate more sales per money invested. The purpose of this paper is to explore and measure the C2C of an international supply chain, namely the export of frozen shrimps from suppliers of shrimps in Thailand to a major retailer in the United States. In this study, the C2C of each supply chain member will be analysed and discussed as the real key to achieving improvement in the C2C is to take a total supply chain approach. It is therefore important to understand how companies perform on this measurement metric as there are huge variations from company to company within a supply chain.
Rotation of independent auditors and analysis of their reports before and after rotation in Brazil

The aim of mandatory rotation of audit firms by public companies is to preserve the independence of the external auditor and reduce errors and fraud associated with the auditing of financial statements. Nevertheless requiring this rotation periodically is a controversial subject, since it involves the commercial and professional relationship of auditors with their clients and the market for auditing. This study focuses on the effect of rotation on the reports issued by audit firms, comparing them before and after the mandatory rotation established by the Brazilian Securities Commission (CVM), effective as of 2004. For this purpose, the auditor´s report was analyzed on the financial statements of 151 listed companies for the period of 2003 to 2006 that changed audit firms as required by the CVM’s rules. According to the results, the rotation of independent auditors did not assure the preservation of independence, nor is there any evidence of an increase in the quality of auditing. However, it was noted that the requirement for periodic rotation led to reduced concentration in the auditing market, with increased participation of small audit firms. Keywords: Auditing; auditor rotation; audit opinion; mandatory rotation.
Hemocyte quantitative changes in Anticarsia gemmatalis (Lepidoptera: Noctuidae) larvae infected by AgMNPV

The initial effects of the infection by AgMNPV in the total and differential counts of the hemocytes in Anticarsia gemmatalis (Lepidoptera: Noctuidae) larvae were studied. The total number of the hemocytes did not decrease in infected larvae, as it occurred in non infected larvae. In infected larvae, the hemocyte types showed the following frequencies: plasmatocytes - 47.8%, esferulocytes - 25.9%, granulocytes - 15.8%, oenocytoids - 7.2%, prohemocytes - 2.8%, vermicytes - 0,5%. Only the percentage of the granulocytes was different among infected and non infected larvae, indicating that these cells responded quickly to the initial viral infection. These results showed the effective role of the hemocytes in the response of the A. gemmatalis to the infection by AgMNPV. The comprehension of the immunological mechanisms of this insect is an important tool to understand its biological control.
EMERGING STOCK PREMIA: SOME EVIDENCE FROM INDUSTRIAL STOCK MARKET DATA

This paper studies the behavior of emerging stock excess returns in an industry-by-industry context. We examine stock market performance for 23 countries and ten industries over 17 years from 1995 to 2012 – a period that includes major changes in capital market regulations, the removal of trade barriers, the IT bubble, the 9/11 terrorist attacks, and the subprime mortgage crisis. In addition, we examine stock market co-movement and risk exposure for ten industries in eight emerging/developing stock markets. We obtain four key empirical findings. First, at industry level, we confirm that the equity risk premium in emerging markets is higher than in developed markets. We also confirm the time-varying nature of emerging stock market excess returns. Second, at country level, we identify those industries that mainly contribute to the presence of the emerging stock premia. Third, we show that some industries are more exposed to global risk factors than others. Fourth, given the increasing degree of co-movement between international stock markets, we observe that some cross-industry portfolio diversification benefits are still exploitable. Our analysis yields interesting implications for financial applications. In particular, we argue that the presence of a strong time-varying component in the “industry-betas” might have strong impact on the estimation of the cost of capital.
Surface electromyography of facial muscles during natural and artificial feeding of infants.

OBJECTIVE To measure and compare the activity of the masseter, temporalis and buccinator muscles in different infant feeding methods. METHOD Cross-sectional study of 60 full-term infants with no intercurrent diseases, aged between two and three months, classified into the following groups: 1) exclusive breastfeeding; 2) breastfeeding plus bottle-feeding; and 3) exclusive breastfeeding plus cup feeding. Surface electromyography was performed during infant feeding. The Krushal-Wallis test was used, complemented by multiple paired comparisons of the groups. A 5% significance level was chosen for the tests. RESULTS Statistically higher results were verified in the breastfeeding group in relation to the bottle-feeding one, both in the range of movement and the mean contraction of the masseter. With regard to the temporalis muscle, statistically higher results were found in the breastfeeding group comparatively to the bottle-feeding one. As to the buccinator muscle, statistically higher results were observed in the breastfeeding group in relation to the bottle-feeding one, although in this case, the difference concerned only the range of contraction. CONCLUSION The similarities between the muscle activity in the breastfeeding and in the cup-feeding groups suggests that cup-feeding can be used as an alternative infant feeding method, being better than bottle-feeding, due to the hyperactivity of the buccinator muscle, which could result in changes to the structural growth and development of the stomatognathic system functions.
CA1‐specific deletion of NMDA receptors induces abnormal renewal of a learned fear response

CA1 hippocampal N‐methyl‐d‐aspartate‐receptors (NMDARs) are necessary for contextually related learning and memory processes. Extinction, a form of learning, has been shown to require intact hippocampal NMDAR signalling. Renewal of fear expression can occur after fear extinction training, when the extinguished fear stimulus is presented in an environmental context different from the training context and thus, renewal is dependent on contextual memory. In this study, we show that a Grin1 knock‐out (loss of the essential NR1 subunit for the NMDAR) restricted to the bilateral CA1 subfield of the dorsal hippocampus does not affect acquisition of learned fear, but does attenuate extinction of a cued fear response even when presented in the extinction‐training context. We propose that failure to remember the (safe) extinction context is responsible for the abnormal fear response and suggest it is a dysfunctional renewal. The results highlight the difference in outcome of extinguished fear memory resulting from a partial rather than complete loss of function of the hippocampus and suggest a potential mechanism for abnormally increased fear expression in PTSD. © 2015 Wiley Periodicals, Inc.
The spermatozoon at fertilisation: Current understanding and future research directions

IntroductionThe primary focus of the Fertility 2003 Third JointSocieties Meeting in Aberdeen was to present anupdate on our understanding of the molecularmechanisms in spermatozoa that result in fertilisa-tion. One symposium focused on our understandingof the molecular mechanisms of those capacitationevents preceding fertilisation and the reader isreferred to the preceding review article (Brewiset al., 2005). This review is based on the secondsymposium, which sought to review our currentunderstanding of mammalian fertilisation mechan-isms, from zona binding to fusion of the fertilisingspermatozoon with the oolemma. This area isdifﬁcult to study and many groups have morerecently focused their studies on capacitation ratherthan fertilisation itself. We were delighted to be ableto invite several researchers, who prove to be theexception to this rule, to participate in this sym-posium, and here we review their presentations andspeculate on future research directions. It is impor-tant to note that this article is not intended to becomprehensive. For more complete reviews thatconsider the spermatozoon at fertilisation, please referto Yanagimachi (1994), Flesch and Gadella (2000),Wassarman et al. (2001), Evans and Florman (2002),Jungnickel et al. (2003) and Talbot et al. (2003). Summary of key fertilisation eventsFertilisation is a unique cell–cell adhesion eventinvolving two structurally disparate gametes thatrecognise, bind and ultimately fuse with each other.Following capacitation, the fertilising spermatozoonmust ﬁrst penetrate the surrounding cumulus mass,(or cumulus oophorus), consisting of follicular cellsdispersed in a polymerised matrix composed mainlyof hyaluronic acid. In most laboratory animals, anacrosome intact spermatozoon makes contact withthe egg to undergo a speciﬁc gamete recognitionprocess. This is mediated by complementary mole-cules associated with the extracellular matrix of theoocyte(thezonapellucida(ZP))andthespermplasmamembrane overlying the acrosomal vesicle. Follow-ing primary sperm-zona binding, the spermatozoon
Migraine, Personality, and Psychiatric Comorbidity

The purpose of this report is to examine the association between migraine and personality, taking into account history of co‐occurring psychiatric disorders. Data came from an epidemiologic study of young adults in the Detroit, Michigan metropolitan area. Migraine, defined according to 1988 IHS criteria, and major depression and anxiety disorders were ascertained by a structured diagnostic interview. Migraine was associated with neuroticism, but not with extraversion or psychoticism, measured by the Eysenck's Personality Questionnaire. The association remained significant, when sex and history of major depression and anxiety disorders were controlled. An excess of 25% of persons with migraine alone, uncomplicated by psychiatric comorbidity, scored in the highest quartile of neuroticism. The results suggest that migraine sufferers might be more vulnerable to psychopathology and poor adjustment to their medical condition.
Demographic Factors Affect Ocular Comfort Ratings During Contact Lens Wear

Purpose To determine if rating of ocular comfort during soft contact lens wear is affected by demographic factors. Methods Retrospective analysis of ocular comfort ratings during soft contact lens wear extracted from 44 nonrandomized similar clinical trials (n = 986). Subjects wore one of seven daily wear silicone hydrogels (SiHy) in combination with one of nine lens care products (LCP), and two daily disposables lenses. The effects on comfort rating of demographic factors were examined after adjusting for lens and LCP effects using general linear model. Results Males reported lower comfort on insertion than females (7.9 ± 1.6 vs. 8.1 ± 1.6, p = 0.001). Over 45 years old had higher comfort ratings than those between 26 and 45 or <26 years old at insertion (8.7 ± 1.3 vs. 8.1 ± 1.6 vs. 7.8 ± 1.6, p < 0.001), during the day (8.6 ± 1.2 vs. 8.0 ± 1.6 vs. 8.2 ± 1.2, p < 0.001), and end of day (7.7 ± 1.6 vs. 6.8 ± 2.0 vs. 7.0 ± 1.6, p < 0.001). Neophytes reported lower comfort on insertion (7.3 ± 1.6 vs. 8.2 ± 1.5, p < 0.001) and during day (8.0 ± 1.3 vs. 8.3 ± 1.3, p = 0.020) than experienced wearers. Participants with Rx ≥−3.50D had higher comfort ratings than those with ⩽−3.50D on insertion (8.3 ± 1.4 vs. 7.8 ± 1.6, p < 0.001), during the day (8.4 ± 1.3 vs. 8.1 ± 1.3, p = 0.010), and end of day (7.2 ± 1.7 vs. 6.9 ± 1.8, p = 0.046). Comfort during the day was different between participants of different ethnic origin (p = 0.024) with Asians reporting the lowest (8.1 ± 1.3). Conclusions Demographic factors such as age, gender, lens wear experience, ethnicity, and refractive status can influence the rating of ocular comfort in clinical studies. The confounding effects of such demographic factors can be controlled by implementing randomization and appropriate multivariable statistical analysis.
DigitalCommons@UNO DigitalCommons@UNO

We study the impact of the U.S. employment-based health insurance system on the employment rate, the shares of full-time/part-time workers, and aggregate hours worked in a general equilibrium life cycle model with incomplete markets and idiosyncratic risks in both income and medical expenses. In contrast to most Europeans, who get universal health insurance from the government, most working-age Americans get health insurance through their employers. We ﬁnd that the employment-based health insurance sys-tem provides Americans with an extra incentive to work and work full-time. In a calibrated version of the model, we assess the extent to which the different health insurance systems account for the differences in employment rate and full-time/part-time shares of workers between the U.S. and European countries. Our quantitative results suggest that the different health insurance systems can account for a signiﬁcant fraction of the differences in employment rate and full-time/part-time shares of workers between the two regions. In addition, we ﬁnd that the employment-based health insurance system is one of the reasons why many Americans work more than Europeans. © 2018 The Authors. Published by Elsevier B
Constraints and Opportunities in Kenyan Manufacturing: Report on the Kenyan Manufacturing Enterprise Survey 2000*

*This Report has not been formally edited. The designations employed and the presentation of material in this publication do not imply the expression of any opinion whatsoever on the part of the Secretariat of the United Nations Industrial Development Organization concerning the legal status of any country, territory, city or area, or of its authorities, or concerning the delimitation of its frontiers or boundaries. The opinions, figures and estimates set forth in signed articles are the responsibilit y of the authors, and should not necessaril y be considered as reflecting the views or carry the endorsement of UNIDO. The designations “developed” and “developing” economies are intended for statistical convenience and do not, necessaril y, express a judgement about the stage reached by a particular country or area in the development process. Mention of f i rm names or commercial products does not imply endorsement by UNIDO.
Growth Companies in the Scandinavian Science Parks

Science parks have become a more wide spread phenomena in Scandinavia as well as in other European countries. Science parks are seen as increasingly important institutions for upgrading the companies’, industries’, region’s and country’s economic base and thereby developing a knowledge-based society. Prior research has however questioned whether science parks do actually generate science-or technology-based companies to any larger degree or whether park-located companies do have higher likelihood of surviving, growing or generating profits. The aim of the paper is to present the results from a survey about the Scandinavian (Denmark, Norway, Sweden) science parks and their “production” of growing technology-based firms. The results show that the older and larger parks do produce growth firms. The number of growth firms have increased in the later half of the 1990s and beginning of 2000, indicating that conditions have improved for science park firms and/or that science parks in general function better. A growth firm in the science parks are on average quite large, some 100 employees and 100 Mkr in turnover, and have raised 176 Mkr in venture capital. The firms are predominantly university spin-offs and recruit PhDs. They often receive both public and private venture capital. Many of them also have relations with large domestic firms as owners and/or important customers and providers of competence.
Respiratory Complications in Iranian Hospitalized Patients with HIV/AIDS

Background The respiratory tract has been the most commonly affected site of illness in HIV-infected patients. The current study was done to identify the frequency of respiratory complications in a consecutive case series of HIV-positive patients in Iran. Materials and Methods This study was a retrospective analysis at the national academic reference medical center of Imam-Khomeini Hospital, in Tehran, Iran. The study included 199 new admissions for 177 HIV-infected patients between 2000 and 2005. Demographic characteristics, risk factors for HIV infection, respiratory complications, and CD4+ lymphocyte counts were evaluated in these patients. Results All patients were males. The mean age was 35 years (age range: 15 to 63 years). Among 34 cases with available CD4+ lymphocyte count results, 70.6% had results <200 cells/mm3. Nearly half the patients (47.7%) had respiratory symptoms. The most common pulmonary complications were cough (86.3%), sputum (71.6%), dyspnea (54.7%), and hemoptysis (10.5%). The most common diagnosis was pulmonary tuberculosis (27.1%), followed by other bacterial pneumonias (16.6%) and pneumocystis carinii pneumonia (4.5%). Intravenous drug users who had history of incarceration had the highest risk factors for Mycobacterium tuberculosis infection (59%), and other bacterial pneumonias (52%). Conclusion Our study demonstrates that respiratory complications are highly frequent in HIV patients in Iran and that pulmonary tuberculosis is still a common complication in HIV infected patients, despite the availability of effective treatment. Results suggest the need for more effective preventive and prophylactic measures, wider use of antiretroviral treatment and effective chemotherapy for Iranian patients with HIV/AIDS.
Revision anatomical reconstruction of the lateral ligaments of the ankle augmented with suture tape for patients with a failed Broström procedure

Aims The aim of this prospective study was to evaluate the intermediate‐term outcomes after revision anatomical ankle ligament reconstruction augmented with suture tape for a failed modified Broström procedure. Patients and Methods A total of 30 patients with persistent instability of the ankle after a Broström procedure underwent revision augmented with suture tape. Of these, 24 patients who were followed up for more than two years were included in the study. There were 13 men and 11 women. Their mean age was 31.8 years (23 to 44). The mean follow‐up was 38.5 months (24 to 56) The clinical outcome was assessed using the Foot and Ankle Outcome Score (FAOS) and the Foot and Ankle Ability Measure (FAAM) score. The stability of the ankle was assessed using stress radiographs. Results The mean FAOS and FAAM scores improved significantly to 87.5 (73 to 94) and 85.1 (70 to 95) points at final follow‐up, respectively (p < 0.001). The mean angle of talar tilt and anterior talar translation improved significantly to 2.8° (0° to 6°) and 4.1 mm (2 to 7) at final followup, respectively (p < 0.001). Side to side comparison in stress radiographs at final follow‐up showed no significant difference. The revision failed in one patient who underwent a further revision using allograft tendon. Conclusion The revision modified Broström procedure augmented with suture tape is an effective form of treatment for recurrent instability of the ankle following a failed Broström procedure. This technique provides reliable stability and satisfactory clinical outcomes at intermediate‐term follow‐up.
Risk Factors for Catheter-Associated Urinary Tract Infections in Critically Ill Patients With Subarachnoid Hemorrhage

ABSTRACT Background: Catheter-associated urinary tract infections (CAUTIs) are preventable adverse outcomes that cause increased morbidity, mortality, and financial burdens to hospitals. These are particularly prevalent in intensive care units (ICUs). Patients with subarachnoid hemorrhage (SAH) in neurological ICUs have extended lengths of stay and may be at higher risk for CAUTIs. Purpose: The purpose of this study was to assess the prevalence of and risk factors for CAUTIs among patients with SAH in the neurological ICU of a large urban teaching hospital in the eastern United States. Methods: This is a retrospective analysis using the Columbia University SAH Outcomes Project data set collected between 2005 and 2012. Logistic regression is used to identify predictors of CAUTI. Results: Catheterized adult patients (n = 242) with SAH over the 8-year period were included. The rate of CAUTIs was 20.7 per 1,000 catheter days, six times higher than the reported national average. Variables significantly associated with CAUTI were older age (odds ratio [OR] = 1.06, 95% confidence interval [CI] [1.01, 1.11]), blood sugar > 200 mg/dl (OR = 13.0, 95% CI [1.28, 107.4]), and anemia requiring transfusion (OR = 3.78, 95% CI [0.977, 14.67]). Conclusions: Higher CAUTI rates in this study were likely associated with prolonged catheterization. On the basis of these findings, careful assessment of the need for catheterization and increased vigilance regarding urinary catheter care in patients with SAH is indicated, particularly among those who are older, with anemia requiring transfusion and elevated blood glucose levels.