Miracle-dz/UniFAR-FTUs huggingface dataset:
Intergenerational Income Elasticities, Instrumental Variable Estimation, and Bracketing Strategies

The fact that the intergenerational income elasticity (IGE)—the workhorse measure of economic mobility—is defined in terms of the geometric mean of children’s income generates serious methodological problems. This has led to a call to replace it with the IGE of the expectation, which requires developing the methodological knowledge necessary to estimate the latter with short-run measures of income. This article contributes to this aim. The author advances a “bracketing strategy” for the set estimation of the IGE of the expectation that is equivalent to that used to set estimate (rather than point estimate) the conventional IGE with estimates obtained with the ordinary least squares and instrumental variable (IV) estimators. The proposed bracketing strategy couples estimates generated with the Poisson pseudo–maximum likelihood estimator and a generalized method of moments IV estimator of the Poisson or exponential regression model. The author develops a generalized error-in-variables model for the IV estimation of the IGE of the expectation and compares it with the corresponding model underlying the IV estimation of the conventional IGE. By considering both bracketing strategies from the perspective of the partial-identification approach to inference, the author specifies how to construct confidence intervals for the IGEs, in particular when the upper bound is estimated more than once with different sets of instruments. Finally, using data from the Panel Study of Income Dynamics, the author shows that the bracketing strategies work as expected and assesses the information they generate and how this information varies across instruments and short-run measures of parental income. Three computer programs made available as companions to the article make the set estimation of IGEs, and statistical inference, very simple endeavors.
Dual-phase helical CT of the liver: value of arterial phase scans in the detection of small (< or = 1.5 cm) malignant hepatic neoplasms.

OBJECTIVE Helical CT scanners now allow sequential arterial phase and portal venous phase scans of the entire liver to be obtained during a single bolus injection of contrast material. The purpose of this study was to determine if arterial phase scans improve detection of small (< or = 1.5 cm) malignant hepatic neoplasms when compared with portal venous scans alone. MATERIALS AND METHODS Dual-phase helical CT of the liver was done in 96 patients referred for known or suspected malignant hepatic lesions. Malignant hepatic neoplasms were detected in 38 patients (27 with at least one small neoplasm), one patient had undetected metastases, one patient had a benign hepatic neoplasm, and 56 patients had no hepatic neoplasm. Proof of individual neoplasms was based on biopsy results, surgical findings, or findings on other imaging studies (primarily follow-up CT). The absence of disease was established by surgical or autopsy findings, findings on subsequent imaging studies, or a combination of clinical and laboratory data. A total of 150 ml of 60% nonionic contrast material was infused at 5 ml/sec followed by sequential arterial phase and portal venous phase helical scans of the liver. Three radiologists retrospectively reviewed the scans. Individual lesions were measured and the conspicuity of each lesion on arterial phase and portal venous phase scans was compared. The percentage of patients in whom some malignant neoplasms were detected better on the arterial phase scan was calculated using categories based on lesion size and typical tumor vascularity. RESULTS In 10 (37%) of 27 patients who had at least one small malignant neoplasm, lesions 1.5 cm or less in diameter were only visible or were more conspicuous on the arterial phase scan. No malignant neoplasms more than 1.5 cm in diameter were visible only on the arterial phase scan. In four (11%) of 38 cases, malignant neoplasms more than 1.5 cm in diameter were more conspicuous on the arterial phase scan. The arterial phase scans improved lesion conspicuity in nine (39%) of 23 patients who had typically hypervascular neoplasms, whereas lesion conspicuity was improved in three (20%) of 15 patients who had typically hypovascular neoplasms (p = .02). The arterial phase scan resulted in the false-positive detection of lesions in two (2%) of 96 cases. CONCLUSION Arterial phase helical CT of the liver improves detection of some small, malignant hepatic neoplasms when performed in addition to portal venous scanning. The value is greatest in those patients who have hypervascular neoplasms.
Disease Modifying Effects of the Spider Toxin Parawixin2 in the Experimental Epilepsy Model

(1) Background: Temporal lobe epilepsy (TLE) is the most common type of epilepsy in adults. It is also the one with the highest percentage of drug-resistance to the current available anti-epileptic drugs (AED). Additionaly, most antiepileptic drugs are only able to control seizures in epileptogenesis, but do not decrease the hippocampal neurodegenerative process. TLE patients have a reduced population of interneuronal cells, which express Parvalbumin (PV) proteins. This reduction is directly linked to seizure frequency and severity in the chronic period of epilepsy. There is therefore a need to seek new therapies with a disease-modifying profile, and with efficient antiepileptic and neuroprotective properties. Parawixin2, a compound isolated from the venom of the spider Parawixia bistriata, has been shown to inhibit GABA transporters (GAT) and to have acute anticonvulsant effects in rats. (2) Methods: In this work, we studied the effects of Parawixin2 and Tiagabine (an FDA- approved GAT inhibitor), and compared these effects in a TLE model. Rats were subjected to lithium-pilocarpine TLE model and the main features were evaluated over a chronic period including: (a) spontaneous recurrent seizures (SRS), (b) neuronal loss, and (c) PV cell density in different regions of the hippocampus (CA1, CA3, DG and Hilus). (3) Results: Parawixin2 treatment reduced SRS frequency whereas Tiagabine did not. We also found a significant reduction in neuronal loss in CA3 and in the hilus regions of the hippocampus, in animals treated with Parawixin2. Noteworthy, Parawixin2 significantly reversed PV cell loss observed particularly in DG layers. (4) Conclusions: Parawixin2 exerts a promising neuroprotective and anti-epileptic effect and has potential as a novel agent in drug design.
Effect of a social intervention of choice vs. control on depressive symptoms, melancholy, feeling of loneliness, and perceived togetherness in older Finnish people: a randomized controlled trial

ABSTRACT Objectives: This study examined effects of a social intervention on depressive symptoms, melancholy, loneliness, and perceived togetherness in community-dwelling Finnish older people. Method: Promotion of mental well-being in older people (GoodMood; ISRCTN78426775) was a single-blinded randomized control trial lasting 1.5 years. Two hundred and twenty-three persons aged 75–79 years reporting symptoms of loneliness or melancholy were randomized into intervention and control groups. The intervention group was allowed to choose among supervised exercise, social activity, or personal counseling. Follow-up measurements were conducted at the end of 6-month intervention, and at 3, 6, and 12 months post intervention. Results: Number of depressive symptoms remained unchanged, while loneliness and melancholy decreased in both the intervention and control groups during the study (p < 0.001). Social integration increased in the intervention group but not in controls (p = 0.041). Attachment and guidance increased in both groups (p < 0.001). Conclusion: The intervention did not alleviate depressed mood. Positive changes over time were observed in loneliness, feelings of melancholy, attachment, and guidance but these occurred independently of the intervention. Our secondary analysis suggests that the intervention increased perceived social integration. In sum, the effects of the intervention were moderate only and did not expedite further overcoming depressive mood or loneliness.
Bridging the gap between heart failure and the device clinic

ABSTRACT Introduction: While cardiac resynchronization therapy (CRT) is a mainstay in the management of selected patients with chronic systolic dysfunction, many patients are noted to experience less than expected or no benefit at all from the therapy. Multidisciplinary care has been shown to provide benefit in follow up for patients receiving CRT devices. Areas covered: This review will focus on the apparent reasons behind less than optimal outcomes following CRT as well as multidisciplinary approaches to treating patients with CRT devices. The literature review focused mainly on the data behind multidisciplinary care of CRT patients. Expert commentary: A multidisciplinary approach incorporating input from various cardiology backgrounds is an important strategy in ensuring optimal outcomes in patients receiving CRT devices. Breaking down the ‘silo’ effect amongst cardiac subspecialties is vital in achieving high level multidisciplinary care.
Interaction of estrogen therapy with calcium and vitamin D supplementation on colorectal cancer risk: Reanalysis of Women's Health Initiative randomized trial

Although calcium and vitamin‐D intake were consistently shown to be inversely associated with colorectal cancer risk in several large prospective studies and protective against adenoma and cancer in multiple randomized trials, the Women's Health Initiative (WHI) of calcium and low‐dose vitamin‐D supplementation trial found no overall effects on colorectal cancer. However, the previous report did not recognize an important biologic interaction with estrogen therapy. We investigated the treatment interaction of estrogen with calcium and vitamin‐D on risk of colorectal cancer via a reanalysis of primary data results from the WHI calcium and vitamin‐D supplementation trial (1,000 mg elemental calcium, 400 IU of vitamin‐D3, or placebo), reanalyzing results from women concurrently randomized to estrogen interventions and placebo. Results indicate that concurrent estrogen therapy was a strong effect modifier of calcium and vitamin‐D supplementation on colorectal cancer risk. While calcium plus vitamin‐D supplementation among women concurrently assigned to estrogen therapies suggested increased risk (Hazard Ratio = 1.50, 95% CI: 0.96–2.33), among women concurrently assigned to placebos arms of the estrogen trials, calcium plus vitamin‐D indicated suggestive benefits (HR = 0.71, 95% CI: 0.46–1.09) (p‐for‐estrogen‐interaction = 0.018). Consistent interaction was also found by reported estrogen use (p interaction = 0.037). Results indicate contrasting effects of calcium and vitamin‐D by concurrent estrogen therapy on colorectal cancer risk. Although further clinical and mechanistic studies are warranted, the potential clinical implications of the apparent interaction of estrogen therapy with calcium and vitamin‐D supplementation should be recognized. Important biological mechanisms related to the key membrane receptor megalin and estrogen‐dependent protein calbindin are discussed. © 2007 Wiley‐Liss, Inc.
Time-resolved dose distributions to moving targets during volumetric modulated arc therapy with and without dynamic MLC tracking.

PURPOSE The highly conformal doses delivered by volumetric modulated arc therapy (VMAT) may be compromised by intrafraction target motion. Although dynamic multileaf collimator (DMLC) tracking can mitigate the dosimetric impact of motion on the accumulated dose, residual errors still exist. The purpose of this study was to investigate the temporal evolution of dose errors throughout VMAT treatments delivered with and without DMLC tracking. METHODS Tracking experiments were performed on a linear accelerator connected to prototype DMLC tracking software. A three-axis motion stage reproduced representative clinical trajectories of four lung tumors and four prostates. For each trajectory, two VMAT treatment plans (low and high modulation) were delivered with and without DMLC tracking as well as to a static phantom for reference. Dose distributions were measured continuously at 72 Hz using a dosimeter with biplanar diode arrays. During tracking, the MLC leaves were continuously refitted to the 3D target position measured by an electromagnetic transponder at 30 Hz. The dosimetric errors caused in the 32 motion experiments were quantified by a time-resolved 3%/3 mm γ-test. The erroneously exposed areas in treatment beam's eye view (BEV) caused by inadequate real-time MLC adaptation were calculated and compared with the time-resolved γ failure rates. RESULTS The transient γ failure rate was on average 16.8% without tracking and 5.3% with tracking. The γ failure rate correlated well with the erroneously exposed areas in BEV (mean of Pearson r = 0.83, p < 0.001). For the final accumulated doses, the mean γ failure rate was 17.9% without tracking and 1.0% with tracking. With tracking the transient dose errors tended to cancel out resulting in the low mean γ failure rate for the accumulated doses. CONCLUSIONS Time-resolved measurements allow pinpointing of transient errors in dose during VMAT delivery as well as monitoring of erroneous dose evolution in key target positions. The erroneously exposed area in BEV was shown to be a good indicator of errors in the dose distribution during treatment delivery.
Interleukin‐10 and interferon‐gamma gene polymorphisms in patients with nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC) is a multifactorial disease. Cytokines driving the immune response seem to be disturbed in NPC patients. Since interleukin‐10 (IL‐10) is known to reduce the production of interferon‐gamma (IFN‐γ), we supposed that genetic differences in IL‐10 and IFN‐γ expression could be a mechanism by which NPC cells escape antitumour immune response. As the production of each cytokine is affected by the genetic background, we investigated the possible association between single nucleotide polymorphisms in genes of IL‐10 and IFN‐γ with NPC. Different IL‐10 –1082 G/A and IFN‐γ+874 Τ/Α genotypes were determined in 160 patients with nasopharyngeal carcinoma and 197 healthy controls. No association was found either for each SNP studied alone or for the combined analysis for both IL‐10 and IFN‐γ polymorphisms among NPC patients in comparison with controls. Compared with individuals from high incidence countries, we noted huge significant differences in genotype distribution between individuals from low and intermediate NPC incidence countries. Polymorphisms of the IL‐10 and IFN‐γ do not appear to be associated with NPC risk in the Tunisian population. Nevertheless, we strongly believe that the relationship between cytokines polymorphisms and NPC susceptibility deeply depends on the ethnicity.
Fibromyalgia Syndrome Module at OMERACT 9: Domain Construct

The objective of the module was to (1) establish a core domain set for fibromyalgia (FM) assessment in clinical trials and practice, (2) review outcome measure performance characteristics, (3) discuss development of a responder index for assessment of FM in clinical trials, (4) review objective markers, (5) review the domain of cognitive dysfunction, and (6) establish a research agenda for outcomes research. Presentations at the module included: (1) Results of univariate and multivariate analysis of 10 FM clinical trials of 4 drugs, mapping key domains identified in previous patient focus group: Delphi exercises and a clinician/researcher Delphi exercise, and breakout discussions to vote on possible essential domains and reliable measures; (2) Updates regarding outcome measure status; (3) Update on objective markers to measure FM disease state; and (4) Review of the issue of cognitive dysfunction (dyscognition) in FM. Consensus was reached as follows: (1) Greater than 70% of OMERACT participants agreed that pain, tenderness, fatigue, patient global, multidimensional function and sleep disturbance domains should be measured in all FM clinical trials; dyscognition and depression should be measured in some trials; and stiffness, anxiety, functional imaging, and cerebrospinal fluid biomarkers were identified as domains of research interest. (2) FM domain outcome measures have generally proven to be reliable, discriminative, and feasible. More sophisticated and comprehensive measures are in development, as is a responder index for FM. (3) Increasing numbers of objective markers are being developed for FM assessment. (4) Cognitive dysfunction assessment by self-assessed and applied outcome measures is being developed. In conclusion, a multidimensional symptom core set is proposed for evaluation of FM in clinical trials. Research on improved measures of single domains and composite measures is ongoing.
ECONOMIC DEVELOPMENT AND INCIDENCE OF FATAL OCCUPATIONAL ACCIDENTS: EVIDENCE FROM THE SELECTED OECD COUNTRIES

Occupational accidents cause significant social and economic problems by the fatal and non-fatal injuries, and are parts of the individual and social costs of production. In this context, we explore the relationship between fatal occupational accidents and economic development for a selected 21 The Organization for Economic Co-operation and Development (OECD) countries over the period of 1995-2013 by performing panel cointegration techniques. The results indicate that cointegration relationship exists among the variables in consideration and by employing pooled mean group estimator method and the results reveal that as an indication of economic development GDP per capita is positively related with fatal occupational accidents in the short-run, however, in the long-run the relationship turns into be negative.
Acute Effects of Two Different Resistance Circuit Training Protocols on Performance and Perceived Exertion in Semiprofessional Basketball Players

Abstract Freitas, TT, Calleja-González, J, Alarcón, F, and Alcaraz, PE. Acute effects of two different resistance circuit training protocols on performance and perceived exertion in semiprofessional basketball players. J Strength Cond Res 30(2): 407–414, 2016—This study aimed to investigate the acute effects of two different resistance circuit training protocols on basketball players' physical and technical performance and rating of perceived exertion (RPE). In a repeated-measures, crossover experimental design, 9 semiprofessional basketball players performed a Power Circuit Training (PCT; 45% 1RM) and a High-Resistance Circuit Training (HRC; 6RM), on consecutive weeks. Vertical and horizontal jump performance, 3-points shooting accuracy, repeated-sprint ability (RSA), agility, and upper body power output were measured before and after training. The RPE was assessed 20 minutes after resistance training. One-way repeated-measures analysis of variance showed performance decrements in vertical jump height and peak power, horizontal jump distance, 3-points percentage, bench-press power output, RSA total and ideal time, and agility T-Test at total time following HRC, but not PCT (p ⩽ 0.05). The RPE was higher in HRC compared with PCT. The results of this study indicated that HRC was perceived as being harder and produced higher fatigue levels, which in turn lowered acute performance. However, low-to-moderate intensity loads did not negatively affect performance. Thus, completing a PCT session may be the most appropriate option before a practice or game as it avoids acute–resistance–training-induced performance decrements. However, if the objective of the basketball session is to develop or perfect technical skills during fatiguing conditions, HRC may be the more suitable option.
Clinical outcomes of natalizumab-associated progressive multifocal leukoencephalopathy

Objective: Natalizumab, a therapy for multiple sclerosis (MS), has been associated with progressive multifocal leukoencephalopathy (PML), a rare opportunistic infection of the CNS associated with the JC virus. We assessed clinical outcomes and identified variables associated with survival in 35 patients with natalizumab-associated PML. Methods: Physicians provided Karnofsky scores and narrative descriptions of clinical status. Data were supplemented by the natalizumab global safety database. Results: At the time of analysis, 25 patients (71%) had survived. Survivors were younger (median 40 vs 54 years) and had lower pre-PML Expanded Disability Status Scale scores (median 3.5 vs 5.5) and a shorter time from symptom onset to diagnosis (mean 44 vs 63 days) compared with individuals with fatal cases. Of patients with nonfatal cases, 86% had unilobar or multilobar disease on brain MRI at diagnosis, whereas 70% of those with fatal cases had widespread disease. Gender, MS duration, natalizumab exposure, prior immunosuppressant use, and CSF JC viral load at diagnosis were comparable. Most patients were treated with rapid removal of natalizumab from the circulation. The majority of patients developed immune reconstitution inflammatory syndrome and were treated with corticosteroids. Among survivors with at least 6 months follow-up, disability levels were evenly distributed among mild, moderate, and severe, based on physician-reported Karnofsky scores. Conclusions: Natalizumab-associated PML has improved survival compared with PML in other populations. Disability in survivors ranged from mild to severe. A shorter time from symptom onset to diagnosis and localized disease on MRI at diagnosis were associated with improved survival. These data suggest that earlier diagnosis through enhanced clinical vigilance and aggressive management may improve outcomes.
First insights into the giant panda (Ailuropoda melanoleuca) blood transcriptome: a resource for novel gene loci and immunogenetics

The giant panda (Ailuropoda melanoleuca) is one of the most famous flagship species for conservation, and its draft genome has recently been assembled. However, the transcriptome is not yet available. In this study, the blood transcriptomes of three pandas were characterized and about 160 million sequencing reads were generated using Illumina HiSeq 2000 paired‐end sequencing technology. The assembly yielded 92 598 transcripts with an average length of 1626 bp and N50 length of 2842 bp. Based on a sequence similarity search against nonredundant (nr) protein database, a total of 38 522 (41.6%) transcripts were annotated. Of these annotated transcripts, 25 142 and 8272 transcripts were assigned to gene ontology terms and clusters of orthologous group, respectively. A search against the Kyoto Encyclopedia of Genes and Genomes Pathway database (KEGG) indicated that 9098 (9.83%) transcripts mapped to 324 KEGG pathways, and the best represented functional categories of pathways were signal transduction and immune system. We have also identified 23 460 microsatellites, 43 560 SNPs as well as 21 456 alternative splicing events in the assembly. Additionally, a total of 24 341 complete open reading frames (ORFs) were detected from the assembly where 1492 ORFs were found to be novel gene loci as these have not been annotated so far in any public database.
Hearing Loss in the Elderly: An Epidemiologic Study of the Framingham Heart Study Cohort

This study used epidemiologic methods to examine hearing loss in the elderly. The Framingham Heart Study Cohort was the reference population. The participants were 935 men and 1358 women, aged 57 to 89 years. Using a conservative definition of hearing loss as threshold levels greater than 20 dB above audiometric zero for at least one frequency from 0.5 to 4 kHz, the prevalence was estimated to be 83%. The majority of cases displayed a sensorineural hearing loss. There were no statistically significant differences by sex at 1 kHz and below. Women had significantly better hearing than men at 2 kHz and above. A multivariate model was constructed to determine which variables had a significant impact upon hearing loss. Under the model, age, sex, illness, family history of hearing loss, Meniere's disease, and noise exposure were significant population risk factors. Age was by far the most critical risk factor.