Miracle-dz/UniFAR-FTUs huggingface dataset:
Model Reference Adaptive H∞ Control for Distributed Parameter Systems of Hyperbolic Type by Finite Dimensional Controllers

The problem of constructing model reference adaptive H∞ control for distributed parameters systems of hyperbolic type is considered in this paper. Distributed parameters systems are infinite dimensional processes, but the proposed control scheme is constructed from finite dimensional controllers. The stabilizing control signal is added to regulate the effect of spill-over terms, and it is derived as a solution of certain H∞ control problem where spill-overs are considered as external disturbances to the process
Expression of Either NF‐κB p50 or p52 in Osteoclast Precursors Is Required for IL‐1‐Induced Bone Resorption

Interleukin (IL)‐1 is implicated in postmenopausal‐ and inflammation‐mediated bone loss. Its expression is regulated by NF‐κB and vice versa. To examine the role of NF‐κB p50 and p52 (they are required for osteoclast formation during embryonic development) in IL‐1‐induced resorption, we used various NF‐κB knockout (KO) mice, including p50−/− and p52−/− single KO, p50−/− and p52+/− (3/4KO), and p50−/− and p52−/− double KO (dKO) mice. IL‐1 increased blood calcium and bone resorption in wild‐type (wt), p50, and p52 single KO mice, but not in 3/4KO or dKO mice. Osteoclast formation was impaired in bone marrow cultures from 3/4KO compared with single KO and wt mice treated with IL‐1. IL‐1 receptor expression was similar in colony forming unit‐granulocyte macrophage (CFU‐GM) colony cells from wt and dKO mice. However, IL‐1 promoted CFU‐GM colony formation and survival as well as the formation, activity, and survival of osteoclasts generated from these colonies from wt mouse splenocytes, but not from dKO splenocytes. No difference in expression of the osteoclast regulatory cytokines, RANKL, and OPG, was observed in osteoblasts from wt and dKO mice. Thus, expression of either NF‐κB p50 or p52 is required in osteoclasts and their precursors, rather than osteoblasts, for IL‐1‐mediated bone resorption.
A new paradigm for temporal masking assessment: pilot study.

PURPOSE To determine the feasibility and applicability of a clinical backward masking test, focusing on the analysis of inter-stimuli interval, and not on the intensity thresholds as it has been traditionally done, thus proposing a new paradigm for temporal masking assessment. METHOD The test consisted of the presentation of a target tone of 1.000 Hz followed by a broadband masking noise (950-1.050 Hz), with inter-stimuli interval of 0, 10, 20, 50 and 100 ms. The stimuli were presented monaurally to both ears, with intensity ratio between masker and target tone varying between -10, -20, -30 and -40 dB. Twenty undergraduate students, without hearing or auditory processing complaints, participated in this study. RESULTS Regardless of the signal-to-noise ratio, we observed decrease of average performance according to the decrease of the interval between stimuli. We also observed the indication that little or no masking occurs at the 100 ms interval, suggesting this interval is unsuitable for temporal masking assessment. The average interval threshold was below 27 ms for all investigated intensities, and increased 9 ms with every increase of 10 dB at signal-to-noise ratio. The signal-to-noise ratios of -20 and -30 were the best ratios for the test application. CONCLUSION The paradigm proposed in this pilot study proved to be feasible, easy to apply, and trustworthy, being compatible with other researches which are the foundation for the study of temporal masking. This theme deserves further studies, continuing the analysis initiated here.
Enhanced production of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) copolymer and antimicrobial yellow pigmentation from Cupriavidus sp. USMAHM13 with antibiofilm capability

ABSTRACT Antibiofilm polymers have the ability to inhibit bacterial biofilm formation, which is known to occur ubiquitously in the environment and pose risks of infection. In this study, production of P(3HB-co-4HB) copolymer and antimicrobial yellow pigment from Cupriavidus sp. USMAHM13 are enhanced through medium optimization. Before the improvement of yellow pigment production, screening for the best additional supplement was performed resulting in high-yield yellow pigmentation using yeast extract with optimum concentration of 2 g/L. Effects of different concentrations of 1,4-butanediol, ammonium acetate, and yeast extract were studied using central composite design. Under optimal conditions, 53 wt% of polyhydroxyalkanoate (PHA) content, 0.35 g/L of pigment concentration, and 5.87 g/L of residual biomass were achieved at 0.56 wt% C of 1,4-butanediol, 1.14 g/L of ammonium acetate, and 2 g/L of yeast extract. Antibiofilm tests revealed that the yellow pigment coated on P(3HB-co-4HB) copolymer had significant effect on the inhibition of bacteria proliferation and colonization from 6 hr onward reaching 100% inhibition by 12 hr, hence effectively inhibiting the biofilm formation.
Is the Rate-of-Change Oscillator Profitable?

The authors evaluate the profitability of trading rules associated with the rate of change (ROC) oscillator. The ROC is an oscillator indicating the trend of the price of a security. Using the data of 13 major stock market indices, they find that the rule generated by the crossing of ROC and its exponential moving average performs extremely well in the stock markets of greater China.
Chronic Pretreatment With Celecoxib Reduces Infarct Size

This study was designed to evaluate the effect of long-term pretreatment with celecoxib, a cyclooxygenase-2 inhibitor, on myocardial infarct size. Celecoxib (3 mg/kg/day i.p; n = 16) or vehicle (DMSO 50%; EtOH 15%; distilled water, n = 16) was administered chronically to male Sprague-Dawley rats through ALZET osmotic pumps for 28 days. Under anaesthesia, the animals were then subjected to left anterior descending coronary artery occlusion for 40 minutes, followed by 24-hour reperfusion. The results show that myocardial infarct size in celecoxib-treated rats was significantly reduced compared to the control group (37.5 ± 2.5% versus 48.0 ± 2.6% of the area at risk, P < 0.05, n = 10 per group). Accumulation of neutrophils, estimated by myeloperoxidase levels, indicated an increase in the ischemic area without any significant difference between groups. No significant difference was observed between the treated and vehicle groups in terms of plasma prostaglandin E2 and tumour necrosis factor-alpha. Apoptosis, evaluated by Bax/Bcl-2 and terminal dUTP nick-end labelled-positive cells, was significantly decreased in the subendocardial layer of the ischemic area in celecoxib-treated rats. This study indicates that pretreatment with celecoxib can reduce infarct size by a mechanism, which may involve apoptosis inhibition.
Experts’ considerations on HLA‐haploidentical stem cell transplantation

Recently, novel strategies to control graft‐versus‐host disease and facilitate engraftment have allowed an increasing number of human leukocyte antigen (HLA)‐haploidentical hematopoietic stem cell transplantation (haploHSCT) to be performed. A meeting was convened to review the biological rationale and the clinical results of various T‐cell‐depleted (TCD) and T‐cell‐replete (TCR) HLA‐haploidentical ‘transplant platforms’. The objective of the meeting was to promote discussion and consent among leading researchers in the field on three main crucial issues for haploHSCT: (i) eligibility criteria, (ii) choice of the most suitable donor, and (iii) choice of the most appropriate transplant platform. The experts in attendance agreed that a patient who is eligible for an allogeneic transplant and lacks an HLA‐identical sibling or an HLA‐matched unrelated donor should be considered for an alternative donor transplant. Together with the experience of the individual center, the most important decision criteria in choosing an alternative donor source should be the rapidity of transplantation so as to avoid disease relapse/progression. The choice of the mismatched donor should be driven by younger age, ABO blood group compatibility, and Cytomegalovirus status. If a TCD transplant is planned, NK‐alloreactive donors and/or the mother should be preferred. Prospective comparative studies are needed to establish the relative efficacy of different transplant platforms. However, expertise in stem cell manipulation and in adoptive immunotherapy is essential if a TCD transplant platform is chosen.
Natural resistance to infection with intracellular pathogens: Cross‐talk between Nramp1 and Lps genes

This study was designed to analyze the association of Nramp1 and/or Lps genes with differential protein expression in macrophages in order to select candidate proteins that might be related to resistance/susceptibility to various microbial infections under the control of the Nramp1 and/or Lps genes. The macrophage cell lines derived from bone marrow of Nramp1 or Lps congenic mice were utilized and high‐resolution two‐dimensional electrophoreis (2‐DE), separating proteins according to their charge and size, was used as a window into alterations in gene expression and a means to compare the macrophages carrying a resistant allele of Nramp1 gene and/or normal allele of Lps gene, with their counterparts carrying either a susceptible allele of Nramp1 or defective allele of the Lps gene. We demonstrate that the changes of constitutive levels of two proteins named according to their isoelectric point/molecular weight (pI/Mr), p6.6/25 and p7.0/22, discriminate satisfactorily not only the macrophages congenic at the Nramp1 gene but also the macrophages congenic at the Lps gene, thus reflecting their common genotype (Nramp1r, Lpsn). Furthermore, the decreased constitutive levels of these proteins in macrophages carrying a defective allele of Lps but preserving a resistant allele of Nramp1 can be, at least in part, restored by stimulation with interferon gamma or lipopolysaccharide. 2‐DE immunoblot analysis identified the p7.0/22 protein as manganese superoxide dismutase. Bcl‐2 appears to be the best candidate for p6.6/25 as suggested by 2‐DE quantitative alterations and Western blot analysis. These proteins are important in the regulation of intracellular redox balance and the regulation of apoptosis in macrophages and their alterations might reflect closely the transport functions of ions or other charged substrates suggested for Nramp1 protein.
Usability of VGI for validation of land cover maps

Volunteered Geographic Information (VGI) represents a growing source of potentially valuable data for many applications, including land cover map validation. It is still an emerging field and many different approaches can be used to take value from VGI, but also many pros and cons are related to its use. Therefore, since it is timely to get an overview of the subject, the aim of this article is to review the use of VGI as reference data for land cover map validation. The main platforms and types of VGI that are used and that are potentially useful are analysed. Since quality is a fundamental issue in map validation, the quality procedures used by the platforms that collect VGI to increase and control data quality are reviewed and a framework for addressing VGI quality assessment is proposed. A review of cases where VGI was used as an additional data source to assist in map validation is made, as well as cases where only VGI was used, indicating the procedures used to assess VGI quality and fitness for use. A discussion and some conclusions are drawn on best practices, future potential and the challenges of the use of VGI for land cover map validation.
Position‐specific expression of Hox genes along the gastrointestinal tract

ABSTRACT Hox genes play a critical role in morphogenesis of the early embryo along the anteroposterior axis. In mammals, 39 Hox genes with extensive homology are organized into 13 paralogous groups, forming four clusters on four separate chromosomes. The genes within each cluster are arranged in a 3′ to 5′ direction and expressed in a temporally and spatially coordinated manner along the anteroposterior axis in the vertebrae, limbs and viscera, including the gastrointestinal tract, but little is known about their spatial expression in the adult gastrointestinal tract. We used the quantitative polymerase chain reaction (PCR) intercalater method with SYBR GreenTM to quantify human Hox gene expression in the adult gastrointestinal tract tissue: esophagus, stomach, duodenum, jejunum, ileum, ileocecum, cecum, ascending colon, transverse colon, descending colon and rectum. Hox gene expression was normalized to glyceraldehyde‐3‐phosphate‐dehydrogenase (GAPDH) gene expression. The spatial expression pattern was analyzed by the multivariate method. The expression level of all 39 Hox genes could be measured in a reproducible manner. Genes with higher expression in the foregut‐derived segments tended to have lower expression in hindgut‐derived segments, whereas those with low expression in the former tended to have higher in the latter. Principal components analysis and permax analysis revealed a position‐specific expression pattern of Hox genes along the anteroposterior axis of the adult gastrointestinal tract. The pattern recapitulates the expression pattern in the embryonic gastrointestinal tract. We suggest that Hox genes may play a pivotal role in the position‐specific regenerative process of intestinal epithelial cells.
Fluid-electrolyte shifts and thermoregulation: Rest and work in heat with head cooling.

Plasma volume and thermoregulatory responses were measured, during head and neck cooling with a liquid-cooled neoprene headgear, in four men (21-43 years old) during 60 min of rest, 60 min of ergometer exercise (45% VO2 max), and 30 min of recovery in the supine position at 40.1 degrees C DBT and 40% rh. Compared with control (noncooling) responses, cooling decreased thigh sweating and increased mean skin temperature (Tsk) at rest, and attenuated the increases in thigh sweating by 0.26 mg/min x cm2 (-22.4%, p < 0.05), heart rate by 10 b/min (-8.5%, N.S.), rectal temperature (Tre) by 0.3 degrees C (N.S.), and ventilation by 12.5% (N.S.) during exercise. In recovery, cooling facilitated the decreases in thigh sweat rate, heart rate, Tre, and forearm blood flow, and enhanced the increase in Tsk toward control levels. Cooling had no effect upon plasma protein, osmotic, or electrolyte shifts during rest, exercise, or recovery. Plasma volume (PV) loss during exercise was 11.2% without cooling and 10.9% with cooling. Cooling increased PV by 3% (p < 0.05) during rest, and this differential was maintained throughout the exercise and recovery periods.
Feasibility of a Health‐Utility Approach to Quantifying Noneconomic Losses from Personal Injury

There is wide agreement that existing approaches to valuing noneconomic losses from personal injury lack coherence. We and others have previously noted the considerable potential for “health utility” measurement — an approach developed in health economics for valuing health outcomes in public health and medicine — to bring greater rationality to assessments of injury-related noneconomic loss. However, the feasibility of creating utility measures that are suitable for use in personal injury compensation has not been demonstrated. This study takes that step. We surveyed 4,129 members of the general public to assess people’s preferences for a variety of non-fatal “health states”. The health states were selected to reflect harms commonly seen in claims to transport accident and workers compensation schemes. We then followed established statistical methods for transforming the survey responses into a “severity weight” for each health state. We show how the severity weights can be used to define tiers in a schedule for guiding noneconomic damages determinations. We discuss the strengths and limitations of the approach, and consider implementation challenges.
The relation between mindfulness and fear of negative evaluation over the course of cognitive behavioral therapy for social anxiety disorder.

OBJECTIVES This study examined the relation between mindfulness and fear of negative evaluation over the course of nonmindfulness based cognitive-behavioral therapy (CBT) for social anxiety disorder (SAD). We expected that higher levels of mindfulness would be associated with a more positive response to treatment. METHOD This study is a secondary report from a randomized controlled trial in which participants (N = 65) diagnosed with SAD were randomly assigned to receive 8 weeks of 1 of 2 manualized treatments (exposure group therapy, n = 33; or virtual reality exposure therapy, n = 32) either immediately or following an 8 week waiting period. RESULTS Fear of negative evaluation decreased following treatment and was negatively related to mindfulness throughout treatment and follow-up. Mindfulness did not moderate treatment outcome. CONCLUSIONS These findings indicate that while mindfulness is related to fear, it is not a moderator of symptom reduction in nonmindfulness-based treatment. Implications for treatment and future research are discussed.
Asparagine improves intestinal integrity, inhibits TLR4 and NOD signaling, and differently regulates p38 and ERK1/2 signaling in weanling piglets after LPS challenge

Asparagine (Asn), an activator of ornithine decarboxylase (ODC), stimulates cell proliferation in intestinal epithelial cells. We hypothesized that Asn can mitigate LPS-induced injury of intestinal structure and barrier function by regulating inflammatory signaling pathways. We executed the following experiment using weanling pigs for each of the groups: (1) non-challenged control; (2) LPS-challenged control; (3) LPS + 0.5% Asn; (4) LPS + 1.0% Asn. After 21-d feeding, pigs received an i.p. injection of either saline or LPS. Four h after injection, the mid-jejunum and mid-ileum samples were collected. We found that Asn restored ODC expression that was decreased by LPS treatment. Asn also restored intestinal morphology and barrier function that were impaired by LPS treatment. In addition, Asn down-regulated intestinal caspase-3 protein expression and TNF-α concentration, and decreased the mRNA expression of intestinal TLR4, TLR4 downstream signals (myeloid differentiation factor 88, IL-1 receptor-associated kinase 1 and TNF-α receptor-associated factor 6 and NOD1, NOD2 and their adaptor molecule (receptor-interacting serine/threonine-protein kinase 2). Moreover, Asn decreased p38 phosphorylation but increased ERK1/2 phosphorylation. Our results suggest that Asn improves intestinal integrity during an inflammatory insult, which appears to be related to the decrease of intestinal pro-inflammatory cytokine (via TLR4, NODs and p38) and of enterocyte apoptosis (via p38 and ERK1/2).
Clearance receptors and endopeptidase : equal role in natriuretic peptide metabolism in heart failure

Rademaker, Miriam Tessa, Christopher John Charles, Teddy Kosoglou, Andrew A. Protter, Eric Arnold Espiner, Michael Gary Nicholls, and Arthur Mark Richards. Clearance receptors and endopeptidase: equal role in natriuretic peptide metabolism in heart failure. Am. J. Physiol. 273 (Heart Circ. Physiol. 42): H2372–H2379, 1997. —The effects of separate and combined endopeptidase inhibition (by SCH-32615) and natriuretic peptide receptor C blockade [by C-ANP-(4—23)] on the clearance and bioactivity of atrial (ANP) and brain (BNP) natriuretic peptides was investigated in eight sheep with heart failure. SCH-32615 and C-ANP-(4— 23) administered separately induced significant and proportionate dose-dependent rises in plasma ANP, BNP, and guanosine 38,58-cyclic monophosphate (cGMP) levels. Associated with these changes were reductions in arterial pressure, left atrial pressure, and peripheral resistance and increases in cardiac output, urine volume, sodium excretion, and creatinine clearance. SCH-32615 induced greater diuresis and natriuresis than C-ANP-(4—23). Combined administration of SCH-32615 and C-ANP-(4—23) induced greater than additive rises in plasma ANP, BNP, and cGMP concentrations, with enhanced hemodynamic effects, diuresis, and natriuresis and reduced plasma aldosterone levels. In conclusion, we find that the enzymatic and receptor clearance pathways contribute equally to the metabolism of endogenous ANP and BNP in sheep with heart failure. Combined inhibition of both degradative pathways was associated with enhanced hormonal, hemodynamic, and renal effects and may have greater potential therapeutic value than either agent separately.
Parathyroid Hormone Regulates the Rat Collagenase-3 Promoter in Osteoblastic Cells through the Cooperative Interaction of the Activator Protein-1 Site and the runt Domain Binding Sequence*

Parathyroid hormone induces collagenase-3 gene transcription in rat osteoblastic cells. Here, we characterized the basal, parathyroid hormone regulatory regions of the rat collagenase-3 gene and the proteins involved in this regulation. The minimal parathyroid hormone-responsive region was observed to be between base pairs −38 and −148. Deleted and mutated constructs showed that the activator protein-1 and the runt domain binding sites are both required for basal expression and parathyroid hormone activation of this gene. The runt domain site is identical to an osteoblast-specific element-2 or acute myelogenous leukemia binding sequence in the mouse and rat osteocalcin genes, respectively. Overexpression of an acute myelogenous leukemia-1 repressor protein inhibited parathyroid hormone activation of the promoter, indicating a requirement of acute myelogenous leukemia-related factor(s) for this activity. Overexpression of c-Fos, c-Jun, osteoblast-specific factor-2, and core binding factor-β increased the response to parathyroid hormone of the wild type (−148) promoter but not with mutation of either or both the activator protein-1 and runt domain binding sites. In summary, we conclude that there is a cooperative interaction of acute myelogenous leukemia/polyomavirus enhancer-binding protein-2-related factor(s) binding to the runt domain binding site with members of the activator protein-1 transcription factor family binding to the activator protein-1 site in the rat collagenase-3 gene in response to parathyroid hormone in osteoblastic cells.
A Cooperative Multiagent Framework for Self-Healing Mechanisms in Distribution Systems

Because of society's full dependence on electricity and high cost of system outages, one important goal is to increase the reliability of the power system, which means that a salient attractive feature of smart grid is its self-healing ability. Smart grids will develop and enhance the automation of distribution by operating in a distributed manner through new digital technologies such as monitoring, automatic control, two-way communication, and data management. In this work, the smart grid concept and technologies have been applied to construct a self-healing framework for use in smart distribution systems. The proposed multiagent system is designed to locate and isolate faults, then decide and implement the switching operations to restore the out-of-service loads. The proposed control structure has two layers: zone and feeder. The function of zone agents in the first layer is monitoring, making simple calculations, and implementing control actions. Feeder agents in the second layer are assigned to negotiation. The constraints include voltage limits, line current limits, and radial topology. Load variation has been taken into consideration to avoid the need for further reconfigurations during the restoration period. The results of the simulation conducted using the new framework demonstrate the effectiveness of the proposed control structure.