Miracle-dz/UniFAR-FTUs huggingface dataset:
Kroppenstedtia guangzhouensis sp. nov., a thermoactinomycete isolated from soil.

A Gram-stain-positive, spore-forming, aerobic and filamentous thermoactinomycete, designated GD02(T), was isolated from soil in south China. The isolate could grow in the presence of 0-3.0 % NaCl (w/v), at temperatures of 30-60 °C and at pH 5.5-9.5, forming ivory-coloured colonies. When the 16S rRNA gene sequence of the isolate was compared with those of other bacteria, the highest similarity was observed with Kroppenstedtia eburnea DSM 45196(T) (96.1 % 16S rRNA gene sequence similarity). The G+C content of the genomic DNA was 56.3 mol%, the cell-wall peptidoglycan contained ll-diaminopimelic acid, the main polar lipids were diphosphatidylglycerol, phosphatidylethanolamine, phosphatidylmethylethanolamine and phosphatidylglycerol, and the major menaquinone was MK-7. The major cellular fatty acids (>5 %) were iso-C15 : 0, iso-C16 : 0, iso-C17 : 0 and anteiso-C15 : 0. On the basis of its phenotypic and phylogenetic properties, chemotaxonomic analysis and the results of physiological and biochemical tests, strain GD02(T) ( = CGMCC 1.12404(T) = KCTC 29149(T)) was designated the type strain of a novel species of the genus Kroppenstedtia, for which the name Kroppenstedtia guangzhouensis sp. nov. is proposed.
Stimulation of oxidation of mitochondrial fatty acids and of acetate by acetylcarnitine.

1. Acetylcarnitine added in catalytic amounts to kidney mitochondria produces an active oxidation of endogenous fatty acids. 2. In conditions of mitochondrial ;aging', under which acetate is not oxidized, acetylcarnitine also promotes the oxidation of this exogenous substrate. 3. Dinitrophenol completely abolishes the action of acetylcarnitine. 4. Carnitine is ineffective both in the oxidation of endogenous fatty acids and of exogenous acetate. 5. The action of acetylcarnitine is shared, though to a smaller extent, by pyruvate. 6. The mechanism of acetylcarnitine action has been interpreted by considering that the readily oxidizable acetyl group of acetylcarnitine can supply the initial investment of energy needed to start fatty acid oxidation.
CLEAR CELL ADENOCARCINOMA OF THE UTERINE CERVIX: A HISTOLOGICAL AND HISTOCHEMICAL STUDY

Summary A case of Mullerian clear cell adenocarcinoma of the uterine cervix occurring in a young woman is presented. A detailed histological and histochemical study of this type of tumour is important so as to separate it from the clear cell tumour of mesonephric origin. The association of Mullerian clear cell adenocarcinoma and other abnormalities of the vagina and cervix with the administration of maternal nonsteroidal oestrogens has been recently stressed in the literature. However, our patient is illustrative of the 30–50% of cases reported to date which have few if any of the associated abnormalities of the genital tract and have no known exposure to nonsteroidal oestrogens.
Implicit Social Network Construction and Expert User Determination for Context-Aware Web Portal Environments

A monitor for determining a buildup of slag on the flame side of water cooled walls of coal fired steam generators and other heat transfer surfaces. This monitor has a body to be positioned in an orientation similar to the water tubes of the steam generator (or other heat transfer surfaces) so that any deleterious buildup on the surfaces will also be effected upon the exterior of the monitor. Positioned within the body of the monitor is a temperature sensor, such is a thermocouple having at least a hot junction. Also positioned within the body and proximate the sensor (e.g., thermocouple) is a heater unit having a high temperature portion located proximate the hot junction. In this manner, when the heater is energized, the hot junction is raised to a preselected temperature. By monitoring the time constant of temperature change of the sensor with current to the heater being cycled, information as to the degree of buildup on the exterior of the body can be obtained. Accordingly, deposit removing equipment of conventional type can be operated when the buildup has reached a point where a change in the heat exchange qualities of the surface has become ineffective. Additional temperature sensors (e.g., thermocouples) can be used to provide temperature information from which instantaneous heat flux can be computed.
Prefrontal and Temporo-Parietal Involvement in Taking Others’ Perspective: TMS Evidence

Introduction: Understanding the mental states of others entails a number of cognitive processes known as Theory of Mind (ToM). Behavioural and functional neuroimaging evidence suggests that prefrontal and temporo-parietal cortices are involved in these abilities. The present study was aimed at investigating the role of the dorsolateral prefrontal cortex and temporo-parietal junction in ToM by using a repetitive transcranial magnetic stimulation (rTMS) paradigm. Material and Methods: Eleven healthy subjects participated in the study. The experimental ToM procedure was constituted by false belief and faux-pas written stories. Subjects were evaluated in baseline condition (Sham) and after 1Hz rTMS over the left/right dorsolateral prefrontal cortex and temporo-parietal junction. A score for accuracy and response times were recorded. Results: As regards false beliefs, rTMS over right prefrontal and temporo-parietal areas significantly interfered with response times (p < 0.05). The application of rTMS over right/left prefrontal and right temporo-parietal cortices also significantly worsened accuracy in the ability to take the others’ perspective in faux-pas tasks as compared to Sham (p ࣘ 0.05 in all cases). Conclusions: The results of the present study are consistent with previous findings supporting the hypothesis that prefrontal and temporo-parietal regions are part of a neural network specifically underpinning the ability to attribute mental states to others.
Chlamydia trachomatis and Neisseria gonorrhoeae

C trachomatis and N gonorrhoeae are major causes of maternal and neonatal morbidity and mortality in developing countries. To identify characteristics predictive of cervical infection, we examined pregnant women attending an antenatal clinic in Nairobi, Kenya. C trachomatis was isolated from 141178 (8%), and N gonorrhoeae from 17 (10%); cervical infection with either pathogen was present in 28 (16%). Two characteristics were independently predictive of cervical infection by logistic regression analysis; the presence of either endocervical mucopus or induced endocervical bleeding, relative risk 4.2 (95% confidence interval (CI) 2.2 to 8.0) and having more than one sexual partner during pregnancy, relative risk 3-3 (95% CI 1-4 to 7.6). A screening programme for cervical infection which tested women with one or both risk markers would have a sensitivity of68% (95% CI 51 to 85%) and a positive predictive value of 0 35 (95% CI 0-22 to-0 47). In countries where resources are limited, diagnostic algorithms incorporating clinical signs and behavioural characteristics may be useful in identifying pregnant women at high risk of cervical infec-
Social life and flexibility of vocal behaviour in Diana monkeys and other cercopithecids

Les etudes recentes portant sur la vie sociale et la production, l'utilisation et la comprehension des vocalisations chez les primates non humains ont ouvert de nouveaux champs de perspectives sur les mecanismes evolutifs de la cognition et de la communication ainsi que l'emergence du langage. Un debat dans la litterature actuelle concerne la flexibilite de la production vocale. En effet, contrairement aux humains, a certains oiseaux et a certains cetaces, la flexibilite vocale des primates non humains semble tres restreinte, a l'origine d'un fosse phylogenetique saisissant. Cependant, les recherches menees sur un certain nombre de cercopitheques africains forestiers ont revele que les cris d'alarme de ces derniers semblaient avoir des proprietes proches de celles du langage humain. Partant de l'hypothese selon laquelle les cris a forte valeur sociale etaient susceptibles de reveler des capacites communicatives encore plus complexes, j'ai etudie en details la vie sociale et le comportement vocal d'une espece de cercopitheques, le singe Diane. Premierement, la comparaison du systemesocial avec celui d'une espece phylogenetiquement proche et connue pour sa flexibilite vocale, la mone de Campbell, a permis de souligner un nombre restreint d'interactions physiques, bien que les femelles entretiennent des relations preferentielles, et que ces relations n'etaient pas biaisees par les liens de parente. Deuxiemement, l'etude du repertoire vocal des femelles Diane a montre qu'il etait restreint mais flexible. Les femelles emettent des cris sociaux a structure combinatoire, dont l'utilisation est modulee par des evenements exterieurs. Troisiemement, le focus sur un cri tres frequent et tres social a revele une flexibilite de la composante identitaire divergence – convergence s'accommodant au contexte. Quatriemement, l'aspect poly-specifique des associations naturelles a ete pris en compte en abordant les capacites de comprehension chez les primates non humains. Des repasses de cris sociaux de singes Brazza ont ete effectuees a trois autres especes de singes de l'ancien monde, les mones de Campbell, les colobes noir et blancs ainsi que les mangabes a collier. Dans l'ensemble, les trois especes etaient capables de differencier des voix heterospecifiques connues de voix jamais entendues. Globalement, les resultats obtenus ont revele un degre considerable de flexibilite dans la communication vocale de primates non humains, ce qui est en accord avec l'hypothese d'une transition evolutive continue depuis la communication vocale animale au langage humain.
The effect of nitidine chloride on the proliferation and apoptosis of nasopharyngeal carcinoma cells.

PURPOSE This study was conducted to investigate the effect of nitidine chloride (NC) on the proliferation and apoptosis of nasopharyngeal carcinoma cell line CNE1, CNE2, TWO3, and C666-1, and to explore its antitumor mechanism. METHODS NC was dissolved in IMDM medium and cultured with nasopharyngeal carcinoma cell line CNE1, CNE2, TWO3 and C666-1. Cell morphology, cell proliferation, cell apoptosis, p53 mRNA and p53 protein levels were assessed. RESULTS After incubation with NC for 24 h, typical apoptotic morphology was observed. NC inhibited the proliferation and induced apoptosis of all 4 cell lines in a time-dose dependent manner. p53 mRNA and p53 protein levels were significantly increased. CONCLUSIONS NC inhibited proliferation and induced apoptosis of nasopharyngeal carcinoma cells with upregulation of p53 gene.
Recommending relevant sections from a webpage about programming errors and exceptions

Programming errors or exceptions are inherent in software development and maintenance, and given today's Internet era, software developers often look at web for finding working solutions. They make use of a search engine for retrieving relevant pages, and then look for the appropriate solutions by manually going through the pages one by one. However, both the manual checking of a page's content against a given exception (and its context) and then working an appropriate solution out are non-trivial tasks. They are even more complex and time-consuming with the bulk of irrelevant (i.e., off-topic) and noisy (e.g., advertisements) content in the web page. In this paper, we propose an IDE-based and context-aware page content recommendation technique that locates and recommends relevant sections from a given web page by exploiting the technical details, in particular, the context of an encountered exception in the IDE. An evaluation with 250 web pages related to 80 programming exceptions, comparison with the only available closely related technique, and a case study involving comparison with VSM and LSA techniques show that the proposed technique is highly promising in terms of precision, recall and F1-measure.
Polymorphisms in ATP-binding cassette transporter genes and interaction with diet and life style factors in relation to colorectal cancer in a Danish prospective case-cohort study

Abstract Background and aims. The ATP-binding cassette (ABC) transporter family transports various molecules across the enterocytes in the gut protecting the intestine against potentially harmful substances. Moreover, ABC transporters are involved in mucosal immune defence through interaction with cytokines. The study aimed to assess whether polymorphisms in ABCB1, ABCC2 and ABCG2 were associated with risk of colorectal cancer (CRC) and to investigate gene–environment (dietary factors, smoking and use of non-steroidal anti-inflammatory drugs) and gene–gene interactions between previously studied polymorphisms in IL1B and IL10 and ABC transporter genes in relation to CRC risk. Materials and methods. We used a Danish prospective case-cohort study of 1010 CRC cases and 1829 randomly selected participants from the Danish Diet, Cancer and Health cohort. Incidence rate ratios were calculated based on Cox’ proportional hazards model. Results. None of the polymorphisms were associated with CRC, but ABCB1 and ABCG2 haplotypes were associated with risk of CRC. ABCB1/rs1045642 interacted with intake of cereals and fiber (p-Value for interaction (Pint) = 0.001 and 0.01, respectively). In a three-way analysis, both ABCB1/rs1045642 and ABCG2/rs2231137 in combination with IL10/rs3024505 interacted with fiber intake in relation to risk of CRC (Pint = 0.0007 and 0.009). Conclusions. Our results suggest that the ABC transporters P-glycoprotein/multidrug resistance 1 and BRCP, in cooperation with IL-10, are involved in the biological mechanism underlying the protective effect of fiber intake in relation to CRC. These results should be replicated in other cohorts to rule out chance findings.
Alpine Skiing With total knee ArthroPlasty (ASWAP): metabolism, inflammation, and skeletal muscle fiber characteristics

We investigated the effect of alpine skiing for 12 weeks on skeletal muscle characteristics and biomarkers of glucose homeostasis and cardiovascular risk factors. Twenty‐three patients with a total knee arthroplasty (TKA) were studied 2.9 ± 0.9 years (mean ± SD) after the operation. Fourteen patients participated in the intervention group (IG) and nine in the control group (CG). Blood samples and muscle biopsies were obtained before (PRE) and 7.3 ± 0.8 days after (POST) the intervention, and blood samples again after a retention (RET) phase of 8 weeks. With skiing, glucose homeostasis improved in IG (decrease in fasting insulin, increase in muscle glycogen) but not in CG. Fiber type distribution and size, as well as capillary density and number of capillaries around the fibers (CAF), were not different between the operated and the non‐operated leg in either group. The relative number of type I fibers increased with skiing in IG with no change in CG. Inflammatory biomarkers, plasma lipids, and mitochondrial proteins and activity did not change. Alpine skiing is metabolically beneficial and can be used as a training modality by elderly people with TKA.
M235T angiotensinogen gene polymorphism and cardiovascular renal risk.

OBJECTIVE In this meta-analysis, we attempted to derive pooled estimates for the putative associations between various cardiovascular-renal disorders and the M235T polymorphism of the angiotensinogen gene. METHODS Case-control studies were combined, using the Mantel and Haenszel approach. Joint P values for continuous variables were calculated by Stouffer's method. Continuous measurements reported in different units were expressed on a percentage scale using the intrastudy mean of the MM genotype as denominator. RESULTS The computerized database used for this analysis included 69 reports with an overall sample size of 27,906 subjects. Overall, possession of the T allele was associated with an increased risk of hypertension. In comparison with the MM reference group (number of studies, n = 32), the excess risk was 31% (P = 0.001) in TT homozygotes and 11% (P = 0.03) in TM heterozygotes. The sensitivity analysis showed that this association was present only in whites (T allelic frequency, f = 42.2%), but not in blacks (f = 77.0%) or Asians (f = 78.0%). Atherosclerotic complications (n = 12), renal microvascular disorders (n = 13), cardiomyopathy (n = 2) or diabetic retinopathy (n = 3) were not correlated with the M235T polymorphism. Publication bias was observed for hypertension, but not for coronary heart disease, including myocardial infarction, and for microvascular nephropathy. Furthermore, in comparison with the MM control group, the circulating angiotensinogen levels (n = 8) were raised by 11 and 7% (P = 0.01) in TT and TM subjects, respectively. In contrast, plasma levels of the angiotensin I converting enzyme (n = 4) and body mass index (n = 15) were not associated with the T allele. CONCLUSION The T allele encoding angiotensinogen is not associated with atherosclerotic or microvascular complications, but in Caucasians behaves as a marker for hypertension. This association, which may have been inflated by publication bias, does not necessarily imply causality.
Robustness Analysis of Asynchronous Sampled-Data Multiagent Networks With Time-Varying Delays

In this paper, we study the simultaneous stability problem of a finite number of locally interconnected linear subsystems under practical constraints, including asynchronous and aperiodic sampling, time-varying delays, and measurement errors. We establish a new Lyapunov-based stability result for such a decentralized system. This system has a particular simple structure of interconnections, but it captures some key characteristics of a large class of intermediate models derived from the consensus analysis of multiagent systems. The asynchrony of aperiodic sampling and the existence of measurement errors allow the utilization of some kinds of quantizing devices, such as Logarithmic quantizers, in the process of data sampling, and allow the introduction of a period of dwell time after each update of state measurement to eliminate the Zeno behavior of events in event-based control. The stability result is applicable to the estimation of the maximum allowable intersampling periods and time delays based on individual dynamics and coupling structures in the scenarios of consensus control via asynchronous sampling of relative states and asynchronous broadcasting of self-sampled states, respectively.
Non-invasive localization of atrial ectopic beats by using simulated body surface P-wave integral maps

Non-invasive localization of continuous atrial ectopic beats remains a cornerstone for the treatment of atrial arrhythmias. The lack of accurate tools to guide electrophysiologists leads to an increase in the recurrence rate of ablation procedures. Existing approaches are based on the analysis of the P-waves main characteristics and the forward body surface potential maps (BSPMs) or on the inverse estimation of the electric activity of the heart from those BSPMs. These methods have not provided an efficient and systematic tool to localize ectopic triggers. In this work, we propose the use of machine learning techniques to spatially cluster and classify ectopic atrial foci into clearly differentiated atrial regions by using the body surface P-wave integral map (BSPiM) as a biomarker. Our simulated results show that ectopic foci with similar BSPiM naturally cluster into differentiated non-intersected atrial regions and that new patterns could be correctly classified with an accuracy of 97% when considering 2 clusters and 96% for 4 clusters. Our results also suggest that an increase in the number of clusters is feasible at the cost of decreasing accuracy.
Ruminal Acidosis – Much More Than pH

Studies show that acidosis is a very significant disorder of cattle. Studies in Wisconsin found that 20.1 and 23% of cows had subacute acidosis as defined by rumen pH < 5.5 (Oetzel et al., 1999, Oetzel, 2004) and others in Ireland had 11% (O'Grady et al., 2008). A large Australian study found that 10% of dairy cows less than 100 days in milk had acidosis, as defined by assessment of ruminal VFA, ammonia, lactic acid, and pH (Bramley et al., 2008). Therefore, it is likely that many cows will experience some level of acidosis during lactation and, indeed, some may be affected many times. It can be estimated that if the prevalence of subacute acidosis is 10% (Bramley et al., 2008) and the duration of a case is 2 days based on data by Golder et al. (2014b), then there would be an incidence of approximately 1500 cases over a 300 d lactation per 100 cows. Understanding and controlling acidosis is therefore critical to ensuring animal well-being and production.
Logarithmically small minors and topological minors

For every integer t, there is a smallest real number c(t) such that any graph with average degree at least c(t) must contain a Kt ‐minor (proved by Mader). Improving on results of Shapira and Sudakov, we prove the conjecture of Fiorini, Joret, Theis and Wood that any graph with n vertices and average degree at least c(t)+ε must contain a Kt ‐minor consisting of at most C(ε,t)logn vertices.
Expansions and contractions of the genetic map relative to the physical map of yeast chromosome III

To examine the relationship between genetic and physical chromosome maps, we constructed a diploid strain of the yeast Saccharomyces cerevisiae heterozygous for 12 restriction site mutations within a 23-kilobase (5-centimorgan) interval of chromosome III. Crossovers were not uniformly distributed along the chromosome, one interval containing significantly more and one interval significantly fewer crossovers than expected. One-third of these crossovers occurred within 6 kilobases of the centromere. Approximately half of the exchanges were associated with gene conversion events. The minimum length of gene conversion tracts varied from 4 base pairs to more than 12 kilobases, and these tracts were nonuniformly distributed along the chromosome. We conclude that the chromosomal sequence or structure has a dramatic effect on meiotic recombination.
Opioids and the Management of Chronic Severe Pain in the Elderly: Consensus Statement of an International Expert Panel with Focus on the Six Clinically Most Often Used World Health Organization step III Opioids (Buprenorphine, Fentanyl, Hydromorphone, Methadone, Morphine, Oxycodone)

1. The use of opioids in cancer pain: The criteria for selecting analgesics for pain treatment in the elderly include, but are not limited to, overall efficacy, overall side‐effect profile, onset of action, drug interactions, abuse potential, and practical issues, such as cost and availability of the drug, as well as the severity and type of pain (nociceptive, acute/chronic, etc.). At any given time, the order of choice in the decision‐making process can change.