Miracle-dz/UniFAR-FTUs huggingface dataset:
Safety and Efficacy of Neuroform for Treatment of Intracranial Aneurysms: A Prospective, Consecutive, French Multicentric Study

The periprocedural morbidity and mortality associated with stent treatment of unruptured wide-neck intracranial aneurysms was evaluated in 107 patients. The rate of aneurysm recurrence was nearly 10% and retreatment was needed in 4% of patients. The rates of periprocedural and longer term embolic events were 3.7% and 3.0%, respectively. Longer term morbidity and mortality were both 1%. Stent-assisted coiling with the Neuroform system provided a high level of occlusion with low rates of subsequent treatment despite a population of patients with predominantly wide-neck aneurysms. BACKGROUND AND PURPOSE: Endovascular embolization of wide-neck intracranial aneurysms can be technically challenging, especially when the anatomy is complex. Stent reconstruction of the parent artery is commonly used to treat wide-neck and bifurcated aneurysms. The main objective of this study was to investigate the periprocedural and midterm morbidity and mortality results of this procedure. MATERIALS AND METHODS: SENAT is a consecutive, prospective, multicentric study. Patients with unruptured cerebral aneurysms who underwent endovascular treatment with the Neuroform stent system were recruited and recorded. Technical outcomes and complications were also assessed. The midterm anatomic results were re-evaluated at 12–18 months. RESULTS: A total of 113 stents were used to treat the 107 aneurysms in 107 patients. The mean width of the aneurysm sac was 6.2 mm, and the mean diameter of aneurysm neck was 4.5 mm. The complete occlusion rate postprocedure was 66.4%. The rate of progressive occlusion at 12–18 months was 14%, and the rate of recurrence was 9.7%. The rate of subsequent treatment was 4%. The thromboembolic rate in the periprocedural period was 3.7%, and the rate of delayed TE events was 3%. Overall, the mortality rate at 12–18 months was 1%, and the permanent morbidity rate was 1%. CONCLUSIONS: Stent-assisted coiling with the Neuroform stent system provides a high level of occlusion with low rates of subsequent treatment despite a predominant population of patients with wide-neck aneurysms. Morbidity and thromboembolic rates were comparable to studies investigating stand-alone coiling.
Improving national data collection systems from voluntary counselling and testing centres in Kenya.

PROBLEM Voluntary counselling and testing (VCT) data from the registered sites in Kenya have been fraught with challenges, leading to insufficient statistics in the national office for planning purposes. An exercise was carried out to determine the barriers to the flow of data in VCT sites in Kenya. APPROACH A record-based survey was conducted at 332 VCT sites in Kenya. Data from on-site records were compared with those in the national office. The exercise was conducted in 2004 between 5 September and 15 October. LOCAL SETTING All registered VCT sites in Kenya. RELEVANT CHANGES After the exercise, various measures to enhance VCT data collection and reporting were implemented. They include the provision of a uniform data collection and reporting tool to all the districts in the country, the strengthening of a feedback mechanism to update provinces and districts on their reporting status and increased support to the data component of the national quality assurance for VCT. LESSONS LEARNED Periodical field visits by the national officials to offer on-the-job training about data management to data collectors and to address data quality issues can dramatically improve the quality and completeness of VCT reports. The perceived relevance of the data and the data collection process to those working at the sites is the critical factor for data quality and timeliness of reporting.
Social defeat stress induces a depression-like phenotype in adolescent male c57BL/6 mice

Abstract Exposure to stress is highly correlated with the emergence of mood-related illnesses. Because major depressive disorder often emerges in adolescence, we assessed the effects of social defeat stress on responses to depressive-like behaviors in juvenile mice. To do this, postnatal day (PD) 35 male c57BL/6 mice were exposed to 10 days of social defeat stress (PD35-44), while control mice were handled daily. Twenty-four hours after the last episode of defeat (PD45), separate groups of mice were tested in the social interaction, forced swimming, sucrose preference, and elevated plus-maze behavioral assays (n = 7–12 per group). Also, we examined body weight gain across days of social defeat and levels of blood serum corticosterone 40 min after the last episode of defeat stress. Our data indicates that defeated mice exhibited a depressive-like phenotype as inferred from increased social avoidance, increased immobility in the forced swim test, and reduced sucrose preference (a measure of anhedonia), when compared to non-defeated controls. Defeated mice also displayed an anxiogenic-like phenotype when tested on the elevated plus-maze. Lastly, stressed mice displayed lower body weight gain, along with increased blood serum corticosterone levels, when compared to non-stressed controls. Overall, we show that in adolescent male c57BL/6 mice, social defeat stress induces a depression- and anxiety-like phenotype 24 h after the last episode of stress. These data suggest that the social defeat paradigm may be used to examine the etiology of stress-induced mood-related disorders during adolescence.
PENGARUH KONDISI KEUANGAN DAN NON KEUANGAN TERHADAP PENERIMAAN OPINI GOING CONCERN PADA PERUSAHAAN MANUFAKTUR DI BEI

This research is a study that tested the effect of Financial Condition, Audit Quality, Audit Opinions of Prior Year, the Company’s Growth, Opinion Shopping of the acceptance of Going Concern in the manufacturing companies listed at Indonesia Stock Exchange. In this study, researchers used purposive sampling and sample size to obtain a sample of 80 manufacturing companies listed on the Stock Exchange in the year 2006-2009. The method of analysis used was logistic regression. The results of this study indicate Financial Condition, audit quality and Opinion Shopping do not affect the going concern opinion reception while the previous year's audit opinion and the Company Growth effect on the acceptance of going-concern opinion.This study’s limitation is the study sampling period is only 4 years old so not ideal for seeing a trend of the influence of financial condition other models, like another Alman Model Revisi. Therefore advisable to consider for using other main variable and banking company as research source in the future studies to discover the difference. Keywords: Going Concern, Financial Condition, Quality Audit, Audit Opinions Prior Year, Company Growth, Opinion Shopping
TRP channels in neurogastroenterology: opportunities for therapeutic intervention

The members of the superfamily of transient receptor potential (TRP) cation channels are involved in a plethora of cellular functions. During the last decade, a vast amount of evidence is accumulating that attributes an important role to these cation channels in different regulatory aspects of the alimentary tract. In this review we discuss the expression patterns and roles of TRP channels in the regulation of gastrointestinal motility, enteric nervous system signalling and visceral sensation, and provide our perspectives on pharmacological targeting of TRPs as a strategy to treat various gastrointestinal disorders. We found that the current knowledge about the role of some members of the TRP superfamily in neurogastroenterology is rather limited, whereas the function of other TRP channels, especially of those implicated in smooth muscle cell contractility (TRPC4, TRPC6), visceral sensitivity and hypersensitivity (TRPV1, TRPV4, TRPA1), tends to be well established. Compared with expression data, mechanistic information about TRP channels in intestinal pacemaking (TRPC4, TRPC6, TRPM7), enteric nervous system signalling (TRPCs) and enteroendocrine cells (TRPM5) is lacking. It is clear that several different TRP channels play important roles in the cellular apparatus that controls gastrointestinal function. They are involved in the regulation of gastrointestinal motility and absorption, visceral sensation and visceral hypersensitivity. TRP channels can be considered as interesting targets to tackle digestive diseases, motility disorders and visceral pain. At present, TRPV1 antagonists are under development for the treatment of heartburn and visceral hypersensitivity, but interference with other TRP channels is also tempting. However, their role in gastrointestinal pathophysiology first needs to be further elucidated.
VR Collide! Comparing Collision-Avoidance Methods Between Co-located Virtual Reality Users

We present a pilot study comparing visual feedback mechanisms for preventing physical collisions between co-located VR users. These include Avatar (a 3D avatar in co-located with the other user), BoundingBox (similar to HTC's "chaperone"), and CameraOverlay (live video feed overlaid on the virtual environment). Using a simulated second user, we found that CameraOverlay and Avatar had the fastest travel time around an obstacle, but BoundingBox had the fewest collisions at 0.07 collision/trial versus 0.2 collisions/trial for Avatar and 0.4 collisions/trial for CameraOverlay. However, subjective participant impressions strongly favoured Avatar and CameraOverlay over BoundingBox. Based on these results, we propose future studies on hybrid methods combining the best aspects of Avatar (speed, user preference) and BoundingBox (safety).
Corporate Governance and Executive Pay: Evidence from a Recent Reform

I examine the effect of the Sarbanes-Oxley Act of 2002 (SOX) on the structure of executive pay. Specifically, I consider the increased board oversight implied by SOX, which is expected to weaken the pay-for-performance link under traditional agency models. Alternatively, if entrenched CEOs managed to capture the pay process before SOX, stronger boards are expected to reduce CEO pay for luck and strengthen pay for performance. Using ExecuComp data, I find that the pay-for-performance link increases after 2002, while pay for luck decreases only in firms with weaker board oversight prior to 2002, that is, in firms more affected by SOX stipulations. In contrast, the pay-for-performance link changes little in firms with independent boards.
Deformation of Crystals: Connections with Statistical Physics

We give a bird's-eye view of the plastic deformation of crystals aimed at the statistical physics community, as well as a broad introduction to the statistical theories of forced rigid systems aimed at the plasticity community. Memory effects in magnets, spin glasses, charge density waves, and dilute colloidal suspensions are discussed in relation to the onset of plastic yielding in crystals. Dislocation avalanches and complex dislocation tangles are discussed via a brief introduction to the renormalization group and scaling. Analogies to emergent scale invariance in fracture, jamming, coarsening, and a variety of depinning transitions are explored. Dislocation dynamics in crystals challenge nonequilibrium statistical physics. Statistical physics provides both cautionary tales of subtle memory effects in nonequilibrium systems and systematic tools designed to address complex scale-invariant behavior on multiple length scales and timescales.
Innovation, cooperation and business performance: Some evidence from Indonesian small food processing cluster

Purpose – The purpose of this paper is threefold: to understand the cooperation activities of small and medium enterprises (SMEs) in food processing industry clusters; to understand the role of cooperation in improving innovation; and to understand the relationship between cooperation, innovation, and business performance of SMEs in food processing industry clusters in rural areas of Indonesia.Design/methodology/approach – An empirical survey was conducted on SMEs in food processing industry clusters. Primary data collected in five SMEs clusters were analyzed by regression and correlation analyses using the path‐analytic approach. In this study, the following two hypotheses were examined: cooperation is positively related to innovation; and innovation of SMEs is positively related to business performance.Findings – Using the path analytical method, this paper provides evidence that cooperation is significantly related to innovation of SMEs in food processing industry clusters. Moreover, business performan.
Corporate Governance and Cross-Listing: Evidence from European Companies

This paper documents the relationship between cross-listing and corporate governance of the largest European companies between 2000 and 2003. Companies with a U.S. cross-listing, and particularly those listed on a U.S. stock exchange had higher corporate governance ratings than companies without a U.S. cross-listing. Corporate governance advantage of the U.S. cross-listed firms holds if we control for the country of origin and other company characteristics, and it was more consistent in 2003 than in 2000, suggesting a possible impact of the Sarbanes-Oxley Act. The U.S. cross-listed firms had higher ratings not only in terms of disclosure but also in terms of board structure and functioning. In contrast, they had no advantage in terms of shareholders' rights and duties. The advantage of U.S. cross-listed firms can be traced back to at least a couple of years before the time of cross-listing, which leaves the question whether their superior corporate governance is the effect of U.S. cross-listing open. In contrast to the importance of cross-listing in the U.S., there is no significant relationship between corporate governance and cross-listing within Europe. Implications are drawn for the debate on bonding and the future of European stock markets.
The Theory of Planned Behaviour as Predictor of Exercise

In a test of the predictive utility of the theory of planned behaviour alone and in conjunction with a number of additional variables, 114 participants completed questionnaires measuring predictor variables and, three weeks later, reported exercise. The results of the present study provide partial support for the theory. Past behaviour was the most predictive variable. Subjective norm was not a significant predictor of intention to exercise. Attitude towards exercise was also not a predictor of exercise intention. Self-monitoring acted as a moderator of the attitude–intention relationship. Perceived behavioural control was not a significant predictor of exercise behaviour, while exercise intentions were only weak predictors. The results also suggested that perceived behavioural control and perceived barriers are not equivalent, and should be treated as separate variables that contribute independently to the predictive ability of the model. The implications of the findings are discussed.
Pharmacological studies of extraocular muscles.

The effects of neuromuscular blocking agents and anticholinesterases on the twitch and tonic neuromuscular systems of the superior rectus muscle and the twitch system of the tibialis anterior muscle were studied in pentobarbital-anesthetized cats. The twitch system is characterized by large-diameter nerve fibers, plaque-like nerve endings, and Fibrillenstruktur muscle fibers; the tonic system by small-diameter nerve fibers, grape-like nerve endings, and Felderstruktur muscle fibers. Depolarizing agents (succinylcholine, decamethonium, Imbretil) increased baseline tension of the superior rectus muscle by their effect on the tonic system. Nondepolarizing agents (d-tubocurarine, dimethyl tubocurarine, gallamine) and depolarizing agents decreased the twitch response of the superior rectus and tibialis anterior muscles by their effect on the twitch system. Anticholinesterases increased the baseline tension and twitch height of the superior rectus muscle, but had a variable effect on the twitch height of the tibialis muscle. It is suggested that saccadic eye movements are a function of the twitch system, while slow sustained activity of the eye is accomplished by the tonic system.
Radiation Therapy Combined with Chemotherapy for Inoperable Pancreatic Carcinoma

From March 1985 to July 1989, 22 patients with unresectable pancreatic adenocarcinoma entered the study to receive external beam irradiation with chemotherapy. Radiation therapy consisted of 60 Gy in 3 courses (20 Gy each course) delivered over a period of 2 weeks, with a 2-week rest between the courses. Chemotherapy consisted of 5 fluorouracil, 500 mg/m2, plus cisplatinum, 20 mg/m2, administered on days 1,2 and 3 of each radiation therapy course. Of the 22 evaluable patients, 10 were males and 12 females; their median age was 63 years (range, 32-77), and their median performance status was 80 (range, 60-90). After treatment, 12 partial remissions and 6 no changes were reported. In 4 cases, abdominal progression of disease during treatment required interruption of the therapy program. At the start of treatment, abdominal pain was the most important symptom in 17 patients; improvement of abdominal pain was observed in 10 cases (76%) after treatment and lasted for a median of 5 months. Median survival time was 7.5 months, and time to progression was 6.2 months. Median follow-up was 7 months (range, 14 days -38). In 2 cases, persistent hematologic toxicity did not permit completion of therapy, and in another 3 cases grade II hematologic toxicity required a 2-week rest period over the normal split-course program. In another 4 cases, grade I hematologic toxicity did not require any delay in the therapy program. Our results are comparable with those achieved in other major studies and are acceptable in terms of survival time, palliation of symptoms and toxicity. In our experience, the combination of radiotherapy plus 5-fluoro-uracil and cisplatinum does not seem to offer any advantage over the combination of radiation therapy and 5-fluorouracil.
EFFECTS OF MAPLE SYRUP URINE DISEASE METABOLITES ON MOUSE l‐FIBROBLASTS IN VITRO: A FINE STRUCTURAL AND BIOCHEMICAL STUDY

—The branched‐chain amino and ketoacids [i.e. l‐leucine, l‐isoleucine, l‐valine, alpha‐ketoisocaproic acid (AKICA), alpha‐keto‐beta‐methylvaleric acid (AKBMVA) and alpha‐ketoisovaleric acid (AKIVA)] were administered to mouse strain l fibroblasts in tissue culture in an attempt to study the effects of increased levels of the compounds in an in vitro system. All of these compounds are found to be elevated in the blood of patients with Maple Syrup Urine Disease (MSUD).
A Distributed Snapshot Protocol for Efficient Artificial Intelligence Computation in Cloud Computing Environments

Many artificial intelligence applications often require a huge amount of computing resources. As a result, cloud computing adoption rates are increasing in the artificial intelligence field. To support the demand for artificial intelligence applications and guarantee the service level agreement, cloud computing should provide not only computing resources but also fundamental mechanisms for efficient computing. In this regard, a snapshot protocol has been used to create a consistent snapshot of the global state in cloud computing environments. However, the existing snapshot protocols are not optimized in the context of artificial intelligence applications, where large-scale iterative computation is the norm. In this paper, we present a distributed snapshot protocol for efficient artificial intelligence computation in cloud computing environments. The proposed snapshot protocol is based on a distributed algorithm to run interconnected multiple nodes in a scalable fashion. Our snapshot protocol is able to deal with artificial intelligence applications, in which a large number of computing nodes are running. We reveal that our distributed snapshot protocol guarantees the correctness, safety, and liveness conditions.
TELISIK PERLAKUAN TEORI ENTITAS USAHA MIKRO, KECIL DAN MENENGAH

Abstract: Study of Entity Theory Treatment on Micro, Small and Medium Enterprises (SMEs). Various challenges and obstacles still occur in SMEs development in Indonesia. One of them is the behavior of SMEs owners who often do not separate personal finance and business capital. Habit of paying for any personal needs is one form of the use of enterprise wealth for personal use. This social reality of SMEs shows the incomprehension of the Economic Entity Concept, the tendency to use the enterprise wealth for personal reason, and business profit/income is treated as “owner’s wallet”. Internalization process can be carried out by “transplantation” of the economic entity concept to eliminate the culture of “sami mawon” exhibited by many actors of SMEs. Abstrak: Telisik Perlakuan Teori Entitas dalam Usaha Mikro, Kecil dan Menengah (UMKM). Beragam tantangan dan hambatan masih memayungi pengembangan UMKM di Indonesia. Salah satunya adalah perilaku pemilik UMKM yang seringkali tidak memisahkan modal bisnis keuangan pribadi dan perusahaan. Kebiasaan pembayaran pelbagai kebutuhan pribadi adalah salah satu bentuk penggunaan sumber daya usaha untuk kepentingan pribadi. Realitas sosial UMKM semacam ini menunjukkan penerapan konsep entitas ekonomi yang tidak komprehensif, kecenderungan penggunaan sumber daya untuk pribadi dan laba/pendapatan usaha bisnis sebagai “kantong ribadi pemilik”. Proses internalisasi melalui “transplantasi” konsep entitas ekonomi dapat diikhtiarkan dalam memberantas budaya “sami mawon” yang dilakoni banyak aktor UMKM.
T1 mapping of the entire lung parenchyma: Influence of respiratory phase and correlation to lung function test results in patients with diffuse lung disease

The T1 values of lung parenchyma of 25 patients with fibrosis and emphysema were measured in the entire lung, and the effect of inspiration and expiration was investigated. T1 map acquisition was based on a snapshot‐fast low‐angle shot (FLASH) sequence. Lung function and blood gas tests were measured. The study documents reverse respiratory phase dependence of T1 measurements of the entire lung parenchyma in patients with emphysema and fibrosis. Furthermore, expiratory measurements showed higher and reverse differences between patient groups compared to inspiratory measurements. For the emphysema group, the average T1 value in inspiration was 1033 ± 74 ms. The average of the mean T1 values in expiration was 982 ± 56 ms. For the patients with fibrosis, the average T1 value in inspiration was 996 ± 103 ms. Compared to that, the average T1 value in expiration was 1282 ± 170 ms. Linear regression of T1 vs. lung function parameters showed the highest regression coefficients for total lung capacity (TLC) and residual volume (RV) in expiration, the values were inversely proportionally dependent on the pooled expiratory T1 values. These findings underline the strong but nonuniform influence of the inspirational status during T1 measurements of the lung. T1 maps in both emphysema and fibrosis should preferably be acquired at expiration if reliable data are to be obtained. Magn Reson Med 59:96–101, 2008. © 2007 Wiley‐Liss, Inc.
On the Nature of Transitions: the Middle to Upper Palaeolithic and the Neolithic Revolution

This article discusses two major revolutions in the history of humankind, namely, the Neolithic and the Middle to Upper Palaeolithic revolutions. The course of the first one is used as a general analogy to study the second, and the older one. This approach puts aside the issue of biological differences among the human fossils, and concentrates solely on the cultural and technological innovations. It also demonstrates the issues that are common-place to the study of the transition from foraging to cultivation and animal husbandry can be employed as an overarching model for the study of the transition from the Middle to the Upper Palaeolithic. The advantage of this approach is that it focuses on the core areas where each of these revolutions began, the ensuing dispersals and their geographic contexts.