Miracle-dz/UniFAR-FTUs huggingface dataset:
Life Goals and Well-Being: Are Extrinsic Aspirations Always Detrimental to Well-Being?

Past research has revealed that relative importance a person places on extrinsic life goals as oposed to intrinsic ones is related to lower well-being. But sometimes it is more important why a goal is being pursued than the content of the goal. Materialistic aspirations will not decrease people's well-being if they help them to achieve basic financial security or some intrinsic goals. On the other hand, if social comparison or seeking power drives extrinsic orientation, these aspirations may be detrimental for well-being, since they do not satisfy satisfy our basic psychological needs. Research from Croatia and other, less rich countries suggest that extrinsic aspirations are not necessarily deterimental but may even contribute to well-being. This finding suggests that various factors can moderate the relationship between aspirations and well-being. Intrinsic life goals may probably be affordable only for people who are well off enough. The meaning of financial success in transitional and poor countries may not necesseraly be associated with purchase and consumption. On the contrary, it may bring opportunities and possibilities of selfexpression and self-growth. Individualistic societies allow individuals to pursue their intrinsic goals while collectivistic cultures stress extrinsic ones. Although this extrinsic orientation may detract their well-being, the sense of individual well-being may not be as important to them as the survival of the group they belong to or so called social well-being.
Allopurinol-induced DRESS syndrome in a 13-year-old girl.

Antihemorroidal hubber Leuco hubber Panotile Bacisporín Linitul antibiótico Poly-pred Bexicortil Liquipom dexa-antibiótico Pomada antibiótica liade Bio-hubber/fuerte Maxitrol Positon crema Blastoestimulina óvulos Neo-analsona Positon crema Blastoestimulina pomada Neo-bacitrin Potison loción Creanolona Neo-bacitrin hidrocortisona Positon ungüento Decadran neomicina Neo-hubber Rinobanedif Deltacina Oftalmolosa cusi Sulfi testin neomicina Dermisone tri-antibiótica prednis.neomi. Synalar ótico Dermo hubber Oftalmowell Tulgrasum antibiótico Fludronef Otosporín Tulgrasum cicatrizante Fml-neo Vinciseptil ótico
An improved geometric descriptor associated with wavelet transform for aggressive human behaviour recognition

Actually, the automatic recognition of aggressive human behaviours becomes an important issue to improve the intelligent security systems and enhance the public safety. In this paper, we propose a robust algorithm which aims to detect an aggressive human behaviour from a monocular vision. The proposed algorithm is based on a spatio-temporal descriptor by using a geometric approach. The latter describes the spatial information of the specific limbs of the body such as arm limb in the form of signatures. To extract the spatio-temporal features, the signatures are normalised and then analysed by the one-dimensional discrete wavelet transform. Thus, a binary support vector machine classifier is used in order to separate either aggressive or non-aggressive behaviours. Several tests have been conducted on the KTH dataset. The obtained results show that the proposed method enables robust recognition in challenging situations, and it is suitable in online action recognition with significant accuracy rate.
Role of Gα12 and Gα13 as Novel Switches for the Activity of Nrf2, a Key Antioxidative Transcription Factor

ABSTRACT Gα12 and Gα13 function as molecular regulators responding to extracellular stimuli. NF-E2-related factor 2 (Nrf2) is involved in a protective adaptive response to oxidative stress. This study investigated the regulation of Nrf2 by Gα12 and Gα13. A deficiency of Gα12, but not of Gα13, enhanced Nrf2 activity and target gene transactivation in embryo fibroblasts. In mice, Gα12 knockout activated Nrf2 and thereby facilitated heme catabolism to bilirubin and its glucuronosyl conjugations. An oligonucleotide microarray demonstrated the transactivation of Nrf2 target genes by Gα12 gene knockout. Gα12 deficiency reduced Jun N-terminal protein kinase (JNK)-dependent Nrf2 ubiquitination required for proteasomal degradation, and so did Gα13 deficiency. The absence of Gα12, but not of Gα13, increased protein kinase C δ (PKC δ) activation and the PKC δ-mediated serine phosphorylation of Nrf2. Gα13 gene knockout or knockdown abrogated the Nrf2 phosphorylation induced by Gα12 deficiency, suggesting that relief from Gα12 repression leads to the Gα13-mediated activation of Nrf2. Constitutive activation of Gα13 promoted Nrf2 activity and target gene induction via Rho-mediated PKC δ activation, corroborating positive regulation by Gα13. In summary, Gα12 and Gα13 transmit a JNK-dependent signal for Nrf2 ubiquitination, whereas Gα13 regulates Rho-PKC δ-mediated Nrf2 phosphorylation, which is negatively balanced by Gα12.
Precision and Accuracy of Fluconazole Susceptibility Testing by Broth Microdilution, Etest, and Disk Diffusion Methods

ABSTRACT Interpretive agreements among the results of fluconazole broth microdilution tests, Etests, and disk diffusion tests were documented by evaluating 495 Candida spp. Microdilution reference test results were in agreement with 96% of the Etest results; most discrepancies were minor differences. Fluconazole resistance of Candida krusei strains often required a full 48 h of incubation in order to be observed by the standard method. For the disk diffusion tests that were performed on Mueller-Hinton agar with glucose and methylene blue, 97% of results were in agreement with those of the reference test, especially when zones of inhibition were measured after the first 24 h of incubation. Some Candida glabrata isolates failed to grow satisfactorily until a full 48 h of incubation was completed. Precision was determined by testing 50 selected isolates in triplicate in each of three laboratories. The reproducibility of results of disk diffusion tests was comparable to that of the reference method. With all procedures, determination of test results was particularly challenging with some strains, and new methods are needed in order to improve endpoint definition.
Cytokine‐induced cell death in immortalized Schwann cells: roles of nitric oxide and cyclic AMP

Tumor necrosis factor‐α and interferon‐γ are pleiotropic cytokines that regulate Schwann cell responses during injury and inflammatory demyelination. We have previously shown that cyclic AMP (cAMP)‐elevating agents decrease the demyelination and Wallerian degeneration in experimental allergic neuritis. In this study, we examined the role of cAMP in cytokine‐mediated signaling in a spontaneously immortal Schwann cell clone (iSC). We found that tumor necrosis factor‐α and interferon‐γ exert synergistic inhibitory action on Schwann cell viability via the production of nitric oxide (NO) and ceramide (cer). Furthermore, we found that: (i) NO synthase inhibitors attenuate the cytokine‐induced cer accumulation and cell death indicating that NO acts upstream of cer; and (ii) cytokine‐induced cell death is decreased in iSCs pretreated continuously for 48–72 h with forskolin, an activator of adenylate cyclase. Although forskolin modulates the phosphorylation of ERKs and Akt, it decreases the susceptibility of iSC to cytokines via a separate mechanism operating after NO induction and before cer accumulation. We propose that the protective effect of cAMP‐elevating agents in experimental allergic neuritis may be mediated in part via modulation of Schwann cell responses to cytokines.
Microbial incidence in upper respiratory tracts of workers in the paper industry

The incidence of microbes in the nasal cavities of workers in three paper and board mills was investigated. A total of 234 persons exposed to microbial aerosols and splashes from paper machine wires and debarker drums formed the exposed group. The control group consisted of 294 workers from the dry working areas: the winding and packing sections. Chi-square analysis was used to test the differences in the frequency of microbial incidence and various symptoms between the exposed and control groups. The nasal cavities of many workers, particularly workers in the debarkers, proved to be contaminated by Klebsiella pneumoniae, other coliforms, yeasts, and molds; usually only one microbe was involved, but sometimes two or several species were found. Nasal bacteria and yeasts were largely derived from the mill and debarker air; the microbes in the air came mainly from process waters. Lack of association of nasopharyngeal symptoms with either exposure to aerosols or nasal microbial contamination was interpreted as an indication of host defenses that were adequate to protect workers from harmful microbial colonization in paper mill environments.
c‐Maf expression in angioimmunoblastic T‐cell lymphoma reflects follicular helper T‐cell derivation rather than oncogenesis

Vicky S Sabine Dana Faratian Tove Kirkegaard-Clausen John MS Bartlett Endocrine Cancer Group, Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh Breakthrough Research Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK, and Department of Breast Cancer Research, Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark 1. Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 1972; 26; 239–257. 2. Ellis PA, Smith IE, Detre S et al. Reduced apoptosis and proliferation and increased Bcl-2 in residual breast cancer following preoperative chemotherapy. Breast Cancer Res. Treat. 1998; 48; 107–116. 3. Porter AG, Janicke RU. Emerging roles of caspase-3 in apoptosis. Cell Death Differ. 1999; 6; 99–104. 4. Kirkegaard T, Naresh A, Sabine VS et al. Expression of tumor necrosis factor alpha converting enzyme in endocrine cancers. Am. J. Clin. Pathol. 2008; 129; 735–743. 5. Faratian D, Kay C, Robson T et al. Automated image analysis for high-throughput quantitative detection of ER and PR expression levels in large-scale clinical studies: the TEAM trial experience. Histopathology 2009; 55; 587–593.
Furrow depth, soil disturbance area and draft force of a seeder-fertilizer at different seeding speeds

Este trabalho teve por objetivo avaliar a profundidade de sulco, area de solo mobilizada e a forca de tracao solicitada por uma semeadora-adubadora de precisao em sistema de plantio direto na cultura do milho, em razao da velocidade de deslocamento. O delineamento experimental foi em blocos ao acaso, com quatro repeticoes em arranjo fatorial 4 x 3, com 12 tratamentos, constituidos de quatro velocidades de deslocamento, obtidas pelos escalonamentos de marchas e de tres rotacoes do motor do trator. Durante a semeadura, monitoraram-se a velocidade de operacao, a rotacao do motor e a forca de tracao na barra. Apos a semeadura, foram avaliadas a profundidade do sulco e a area mobilizada de solo. Os resultados mostraram que: a profundidade do sulco foi influenciada pelo aumento na velocidade de operacao; a area mobilizada de solo aumentou em 41 % com a elevacao da velocidade de operacao; o requerimento de forca na barra de tracao, media, por linha de semeadura e por area mobilizada de solo diminuiu com o aumento da velocidade; e a forca media na barra de tracao por profundidade do sulco aumentou com o incremento da velocidade de operacao.
Molecular Plasmonics: Chromophore–Plasmon Coupling and Single-Particle Nanosensors

This review describes investigations into the localized surface plasmon resonance (LSPR) of silver nanoparticles from both experimental and theoretical perspectives. It is divided into two parts: 1) LSPR of silver nanoparticle arrays and its interaction with resonant adsorbates and 2) single-nanoparticle LSPR spectroscopy and sensing of two specific nanoparticle geometries: triangular nanoprisms and nanocubes. Part I addresses the problem of strong coupling between the plasmon resonance of the nanoparticle and the molecular electronic resonances of the adsorbates. In particular, it was shown that the shift in the LSPR wavelength induced by resonant adsorbates binding to nanoparticles is highly dependent upon the relative spectral position of the LSPR to the molecular resonance. This finding was applied to study the electronic structures of resonant adsorbates on metallic nanostructures. Furthermore, an optical nanosensor was designed to study low molecular weight substrate molecule interaction with cytochrome P450 proteins. Part II shows that the LSPR spectra of single nanoparticles are highly sensitive to all details of their geometry. These geometric details play an important role in determining the utility of a nanoparticle as a sensor. It was demonstrated that nanoprisms have a 1 nm per CH2 unit greater sensitivity to the binding of molecular adsorbates than truncated tetrahedral arrays despite being five times thinner, suggesting they will be excellent candidates for sensing large biomolecules. It was further shown, for the case of the nanocubes, that the energy of LSPR modes are not simply sensitive to their environments, but that the environment can actually affect the number of modes observed in a nanoparticle's LSPR spectrum. A figure of merit (FOM) has been defined for single-nanoparticle sensors, and the nanocubespsila high-energy peaks were shown to have the highest-value FOM measured to date.
Dynamic Capabilities and the Speed of Strategic Change: Evidence From China

Despite the general agreement of the importance of resources and capabilities to strategic change, the broader question of how resources and capabilities affect strategic change itself remains unresolved. This research focuses on one characteristic of the process of strategic change, i.e., its speed. This study investigates the relationship between dynamic capabilities, the speed of strategic change, and performance. We propose that technological capabilities, marketing capabilities, and market-linking capabilities, due to their absorptive capacity and boundary spanning attributes, will facilitate the speed of strategic change. Furthermore, the risk orientation of managers will moderate this effect such that it would be strengthened for relatively risk-taking managers. Finally, we argue that the speed of strategic change will have an inverted-U relationship with organizational performance. We test these hypotheses on a sample of 213 Chinese firms and find that while dynamic capabilities facilitate rapid strategic change, the risk orientation of decision makers moderates this relationship, but not all as hypothesized. While faster implementation of strategic change has a positive effect on performance, strategic change carried out too quickly has negative performance repercussions. Our findings suggest that firms not only need to adjust strategies to complement the changing environment, but also have corresponding capabilities to enable rapid strategic change.
Application bundling in system markets ∗

Motivated by recent investigations over Google’s practices in the smartphone industry, we study bundling in markets for devices that allow consumers to use applications. The presence of applications on a device increases demand for it, and application developers earn revenues by interacting with consumers. A ﬁrm that controls multiple applications can oﬀer them to device manufacturers either individually or as a bundle. We present a novel mechanism through which anti-competitive bundling can be proﬁtable: Bundling reduces rival application developers’ willingness to pay manufacturers for inclusion on their devices, and allows a multi-application developer to capture a larger share of industry proﬁt. Bundling can also strengthen competition between manufacturers and thereby increase consumer surplus, even if it leads to foreclosure of application developers and a loss in product variety.
Cerebral hemodynamics in the different phases of migraine and cluster headache

Headache is one of the most common ailments; migraine is one of the most prevalent and disabling neurological disorders and cluster headache presents as one of the most excruciating pain disorders. Both are complex disorder characterized by recurrent episodes of headache. A key feature is that various triggers can set off an attack providing the opportunity to explore disease mechanisms by experimentally inducing attacks. This review summarizes neuroimaging and hemodynamic studies in human in provoked and spontaneous attacks of migraine and cluster headache. Cerebral hemodynamics during different phases of the migraine attack demonstrate alterations in cerebral blood flow and perfusion, vessel caliber, cortical and sub-cortical function, underscoring that migraine pathophysiology is highly complex. Migraine attacks might begin in diencephalic and brainstem areas, whereas migraine aura is a cortical phenomenon. In cluster headache pathophysiology, the hypothalamus might also play a pivotal role, whereas the pattern of cerebral blood flood differs from migraine. For both disorders, alterations of arterial blood vessel diameter might be more an epiphenomenon of the attack than a causative trigger. Studying cerebral hemodynamics in provocation models are important in the search for specific biomarkers in the hope to discover future targets for more specific and effective mechanism-based anti-headache treatment.
Consumption and Growth Rates of Chaetognaths and Copepods in Subtropical Oceanic Waters

The natural rates of food consumption and growth were calculated for the chaetognath Pterosagitta draco and the copepod Scolecithrix danae in the Pacific Ocean near Hawaii. The chaetognath's consumption rate was calculated using the observed frequency of food items in the stomachs of large specimens from summer samples and the digestion times from previous publications. The natural consumption rate averaged only one copepod per 24 hr, or about 2 percent of the chaetognath's nitrogen weight per 24 hr. The growth rates of both P. draco and S. danae were calculated with the temporal patterns of variations in the size compositions of the spring populations. The natural growth rates averaged only 2 and 4 percent of the body nitrogen per 24 hr for, respectively, small P. draco and the copepodids of S. danae. These natural rates were low in comparison with published laboratory measurements of radiocarbon accumulation, nitrogen excretion, and oxygen respiration of subtropical oceanic zooplankton. THE RATES OF FOOD CONSUMPTION, metabolism, and growth have been determined for zooplankton in some regions of the oceans. Temperate and coastal rates have been described by Mullin (1969), Petipa et al. (1970), and Shushkina et al. (1974). Subtropical neritic rates have been measured by Beers (1964), Mayzaud and Dallot (1973), Newbury and Bartholomew (1976), Reeve (1970), and Reeve and Baker (1975). Less information is available on the rates of subtropical oceanic zooplankton, and this information is reviewed below in detail. Perhaps the main reason for the lack of determinations of the functioning rates of subtropical oceanic zooplankton is that the methods of measurement are difficult and/or indirect. Laboratory culture is difficult with natural oceanic foods at low environmental 1 This research was supported by National Science Foundation grant no. GA-36820. Manuscript accepted
Endocrine abnormalities in patients with adrenal tumours incidentally discovered on computed tomography.

To determine endocrine activity of adrenal tumours incidentally discovered on C.T. , we examined 20 consecutive patients. They underwent thorough hormonal assessment and scintigraphic scanning with radioactive cholesterol under dexamethasone suppression (19 patients). Biochemical findings compatible with cortisol hypersecretion were detected in 5 patients. One patient had reduced reserves of cortisol secretion and one had hyporeninemic hypoaldosteronism. The scintigraphy showed no uptake in 10, unilateral uptake in 4, and bilateral uptake in 5 patients. In 3 patients the finding was unilateral on CT. but bilateral on scintigraphy. Signs of autonomous cortisol production were more common among patients who had uptake on scintigraphy. At the operation of 8 patients only benign lesions were found. During the follow-up (9 to 49 months) of the 12 unoperated patients, the tumour disappeared in one and remained unchanged in the others. No changes occurred in the biochemical findings except in one patient whose cortisol response to 1 mg of dexamethasone became abnormal. Since slight hypercortisolism or a bilateral disease often exists behind an incidentally discovered adrenal tumour, we emphasize the importance of careful assessment of cortisol metabolism and a scintigraphic scanning under dexamethasone suppression in the examination of these patients.
Modeling and experimental study of nanoelectromechanical oscillator using single zinc oxide nanowire

This paper reports a novel nanoelectromechanical oscillator using a single zinc oxide (ZnO) nanowire suspended across two micromachined Au electrodes. The oscillator is self-driven into a motion that is self-detected by using a field effect transistor (FET) configuration and a lock-in detection method. A continuum electromechanical model is established to realize a theoretical analysis on the oscillator and the primary experimental measurements are performed to validate the effectiveness of the device. Compared with other nanoelectromechanical oscillators, such as that with carbon nanotubes, the oscillator based on ZnO nanowire is provided with an enhanced electromechanical response and an observable resonance with a frequency on the order of tens of megahertz driven in an air environment. These merits significantly enhance the device's practicability. The device can be potentially applied for actuators and sensors.
Compact modeling of thermal noise in the MOS transistor

Although some of the recently proposed compact models for thermal noise in MOS transistors exhibit a good match with experimental data, we believe most of the existing compact models suffer from incorrect physical assumptions or modeling (e.g., absence of carrier heating, incorrect modeling of velocity saturation effect, wrong modeling of diffusivity, etc.). This brief presents a new, completely analytical thermal noise model based on consistent physical assumptions.