Miracle-dz/UniFAR-FTUs huggingface dataset:
Cocaine-Conditioned Place Preference by Dopamine-Deficient Mice Is Mediated by Serotonin

Rodents learn to associate the rewarding effects of drugs with the environment in which they are encountered and, subsequently, will display a conditioned place preference (CPP) for that environment. Cocaine-induced CPP is generally thought to be mediated through inhibition of the dopamine transporter and the consequent increase in extracellular dopamine. However, here we report that dopamine-deficient (DD) mice formed a CPP for cocaine that was not blocked by a dopamine D1-receptor antagonist. Fluoxetine, a serotonin transporter (SERT) inhibitor, produced CPP in DD, but not control mice, suggesting that serotonin mediates cocaine CPP in DD mice. Inhibition of dopamine neuron firing by pretreatment with quinpirole, a dopamine D2-receptor agonist, blocked both cocaine- and fluoxetine-induced CPP in DD mice. These findings are consistent with the hypothesis that, in the absence of dopamine, cocaine-mediated SERT blockade activates dopamine neurons, which then release some other neurotransmitter that contributes to cocaine reward in DD mice.
Full spectrum endoscopy (FUSE) versus standard forward-viewing endoscope (SFV) in a high-risk population

Abstract Objectives: To investigate the diagnostic performance of Full Spectrum Endoscopy (FUSE) compared to a conventional standard forward-viewing endoscope (SFV). The primary outcome was adenoma detection rate (ADR) and mean adenoma detection. Secondary outcome was feasibility of FUSE opposed to SFV. Materials and methods: Consecutive patients participating in the Danish colorectal cancer (CRC) screening programme were prospectively included in the study (n = 205). Demographic and health-related characteristics were obtained. Following procedural parameters were recorded: completion rate, caecal intubation time, fentanyl and midazolam sedation, CRC detection, ADR, diverticulosis, bowel preparation, patient discomfort and endoscopist difficulty rating. Participants underwent FUSE colonoscopy on days when the FUSE system was available, while the remaining participants had SFV. All colonoscopies were performed by two trained endoscopists. Results: A total of 109 patients were included in the FUSE group and 106 in the SFV group. Groups were comparable in baseline characteristics. Completion rate was 83.5% and 93.4% in the FUSE and SFV groups (p = .040). Caecal intubation time was 11.4 ± 6.7 min versus 9.1 ± 6.2 min in the FUSE and SFV groups (p = .040). ADR was 67.0% and 59.6% (p = .097), while the mean adenoma detection was 1.79 and 1.38 (p = .022) in the FUSE and SFV groups. Endoscopists reported increased difficulty rating with FUSE compared to SFV (p > .001). Conclusion: FUSE colonoscopy provides a higher mean adenoma detection and there is tendency toward higher ADR compared to SFV in a high-risk population. Nonetheless, FUSE colonoscopy has a lower completion rate, longer caecal intubation time and a higher difficulty rating from an endoscopist point of view.
Budget Hotels’ Online Guest Reviews Regarding Customer Satisfaction

The tourism industry is an industry that uses services as its products, yet the services themselves are intangible. There are many different aspects to the tourism industry and one of them is accommodation, which includes hotels. Most hotels face similar issues in their operations and business, and technology is one way to listen and respond to complaints from guests. Technology has helped many industries to grow and flourish in the modern age. The tourism industry is one of the industries that relies heavily on technology. Hotels use technology for reservations, payments, room smartcards, taking orders at restaurants, and many other things. Travel search engines are the main reference for guests, other than the official website of the hotel. This paper aims to study the factors and level of customer satisfaction in a budget hotel in Shah Alam, Selangor Darul Ehsan, Malaysia, based on guests’ online reviews. This research was conducted by analysing the secondary data gathered from booking websites. Using the data selected from the travel search engine, it is hoped that the findings can measure the level of customer satisfaction at this budget hotel and provide methods of improvement for future business operations.
Clinical predictors of high risk histopathology in retinoblastoma

Previous studies show that clinical features at presentation, in retinoblastoma patients, like glaucoma and neovascularization of iris are associated with a higher incidence of high risk histopathology findings (HRF) in enucleated eyes. Herein, we analyze association between clinical features at time of enucleation and occurrence of HRF including invasion of anterior chamber, iris, ciliary body, choroid (massive), sclera, extrascleral tissue, optic nerve beyond lamina cribrosa, and optic nerve cut end, in a large series of eyes enucleated for retinoblastoma.
Therapeutic effect of Qingyi decoction in severe acute pancreatitis-induced intestinal barrier injury.

AIM To investigate the effect of Qingyi decoction on the expression of secreted phospholipase A2 (sPLA2) in intestinal barrier injury. METHODS Fifty healthy Sprague-Dawley rats were randomly divided into control, severe acute pancreatitis (SAP), Qingyi decoction-treated (QYT), dexamethasone-treated (DEX), and verapamil-treated (VER) groups. The SAP model was induced by retrograde infusion of 1.5% sodium deoxycholate into the biliopancreatic duct of the rats. All rats were sacrificed 24 h post-SAP induction. Arterial blood, intestine, and pancreas from each rat were harvested for investigations. The levels of serum amylase (AMY) and diamine oxidase (DAO) were determined using biochemical methods, and serum tumor necrosis factor (TNF)-α level was measured by an enzyme linked immunosorbent assay. Pathologic changes in the harvested tissues were investigated by microscopic examination of hematoxylin and eosin-stained tissue sections. The expressions of sPLA2 at mRNA and protein levels were detected by reverse transcriptase PCR and Western blot, respectively. A terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling assay was used to investigate apoptosis of epithelial cells in the intestinal tissues. RESULTS Compared to the control group, the expression of sPLA2 at both the mRNA and protein levels increased significantly in the SAP group (0.36 ± 0.13 vs 0.90 ± 0.38, and 0.16 ± 0.05 vs 0.64 ± 0.05, respectively; Ps < 0.01). The levels of AMY, TNF-α and DAO in serum were also significantly increased (917 ± 62 U/L vs 6870 ± 810 U/L, 59.7 ± 14.3 ng/L vs 180.5 ± 20.1 ng/L, and 10.37 ± 2.44 U/L vs 37.89 ± 5.86 U/L, respectively; Ps < 0.01). The apoptosis index of intestinal epithelial cells also differed significantly between the SAP and control rats (0.05 ± 0.02 vs 0.26 ± 0.06; P < 0.01). The serum levels of DAO and TNF-α, and the intestinal apoptosis index significantly correlated with sPLA2 expression in the intestine (r = 0.895, 0.893 and 0.926, respectively; Ps < 0.05). The levels of sPLA2, AMY, TNF-α, and DAO in the QYT, VER, and DEX groups were all decreased compared with the SAP group, but not the control group. Qingyi decoction intervention, however, gave the most therapeutic effect against intestinal barrier damage, although the onset of its therapeutic effect was slower. CONCLUSION Qingyi decoction ameliorates acute pancreatitis-induced intestinal barrier injury by inhibiting the overexpression of intestinal sPLA2. This mechanism may be similar to that of verapamil.
Glucocorticoid receptors in cord blood lymphocytes of healthy neonates and of preterms suffering from respiratory distress syndrome

We measured the number of glucocorticoid receptors (GR) in cord blood lymphocytes and the binding affinity (Kd) in 15 term and in 20 preterm babies. Thirteen preterms of the latter group received prenatal steroid treatment. Seven preterms developed neonatal respiratory distress syndrome (NRDS). The number of GR and the Kd were similar in the term and preterm (with and without NRDS) babies. The maximum thymidine incorporation into DNA of cord blood lymphocytes from all preterms, with or without NRDS was suppressed when compared to that from term babies or adults. This could partly be explained by the antenatal steroid treatment. Sensitivity (ID50) of the lymphocytes for the inhibitory effect of dexamefhasone was the same in all groups. In this study on the number and function of GR in lymphocytes, we were unable to find a relation between the functionality of the GR and the development of NRDS.
Monogenic polycystic ovary syndrome due to a mutation in the lamin A/C gene is sensitive to thiazolidinediones but not to metformin.

CONTEXT Despite the very high prevalence of the polycystic ovary syndrome (PCOS), the underlying pathogenetic mechanism has remained obscure. OBJECTIVE To determine the cause of two sisters' PCOS associated with severe insulin resistance. DESIGN Clinical case report. Methods Two sisters who presented with hyperandrogenism and menstrual disorders in the context of PCOS, and were subsequently found to be severely insulin resistant. Physical examination revealed muscular hypertrophy with a paucity of fat in the extremities, trunk and gluteal regions, in spite of excess fat deposits in the face, neck and dorsocervical region. Known genes involved in familial partial lipodystrophy were screened. At the same time, metformin (1700 mg/day) was commenced. After 2-3 years of uninterrupted therapy, lack of clinical improvement led to the introduction of pioglitazone (30 mg/day). RESULTS Both sisters were found to be heterozygous for the R482Q mutation in the lamin A/C gene (LMNA) gene, establishing the definitive diagnosis as Dunnigan-type familial partial lipodystrophy complicated by severe insulin resistance and secondary PCOS. Treatment with pioglitazone resulted in progressive amelioration of insulin resistance, hyperinsulinaemia and hyperandrogenaemia. Menses also improved, with restoration of a eumenorrhoeic pattern, and the framework of ultrasound PCO was in complete remission. CONCLUSIONS Assessment of insulin sensitivity and adipose tissue topography should be a key part of the initial evaluation of patients with PCOS. Identifying such forms of PCOS with monogenic insulin resistance as the primary pathogenic abnormality may have practical implications for therapy, since they respond to thiazolidinediones, but not to metformin.
Assessing the accuracy of Sentiment Analysis of Social Media Posts at Small and Medium-Sized Enterprises in Southern Germany

In recent years, small and medium-sized enterprises (SMEs) have increasingly adopted Social Media technologies with the purpose of fostering the bidirectional communication with customers or to facili-tate the collaboration between employees amongst each other. Thereby, customer posts in a company’s Social Media channels capture consumers’ current attitude towards product and service offerings or the enterprise as a whole. An automatic analysis of these posts does not only provide a firm with valuable knowledge on the customer relationship, but also frees up human resources in case the posts were screened by employees manually hitherto. However, posts in Social Media channels of SMEs are char-acterized by certain peculiarities such as regional slang or off-topic discussions amongst others. The study at hand investigates the impact of such characteristics on the accuracy of results received from an automatic sentiment analysis of corresponding posts. In this context, we revert to Social Media posts of five SMEs from southern Germany. The results show that an adaption of approaches used for senti-ment analysis to the specific language of customers and firms is mandatory for achieving a high level of accuracy.
A Day and Night Vision MOS Imager With Robust Photonic-Crystal-Based RGB-and-IR

This paper demonstrates a day and night vision MOS imager with red, green, blue (RGB) and extra near-infrared filters placed over individual pixels. The on-chip RGB and IR filters are fabricated from an inorganic photonic crystal color filter (PCCF) technology, thereby realizing a robust and reliable camera module for indoor and outdoor use without mounting a mechanical IR-cut filter. These PCCFs allow the IR band as well as the RGB bands to pass through to the RGB photodiodes from which RGB signals, each involving some amount of IR component, are derived. During the daytime, however, chromatically almost pure RGB colors are reproduced by subtracting a weighed IR signal of an extra IR pixel from the raw RGB signals of the surrounding IR pixels. As a result, the IR components in the resultant RGB signals are minimized from 25%, 21%, and 50% to 9%, 4%, and 21%, respectively. During the night, on the other hand, an IR image having a resolution match with a conventional IR imager can be captured by using the IR components of the raw RGB signals with the IR signal.
Anthropogenic Factors Affecting the Status of Salmon Stocks in Pacific Northwest Watersheds

Abstract : Anthropogenic effects on watersheds are important in explaining the decline of Pacific Northwest salmon stocks. Associations were tested between thirteen anthropogenic variables in 202 watersheds in Washington, Oregon, Idaho and California and the stock status of summer, spring and fall Chinook Onchorhynchus tshawytsha, coho O. kisutch, and winter steelhead O. mykiss. Summer Chinook had the highest risk status, followed by spring Chinook, coho, fall Chinook and winter steelhead. Difference in life history characteristics helped explain some of the results. Significant associations (P 0.001) were found between the status of salmon and all anthropogenic variables, but dams were the only variable associated with higher risk stocks for all species and races. The combination of dams, subdivision development, USFS land, and watershed groups, correctly classified 95% of summer Chinook stocks. Number of dams and absence of wild and scenic rivers correctly classified 86% of spring Chinook stocks. Watershed groups, human population, and number of dams correctly classified 77% of coho stocks. Number of dams, USFS land and lack of forest area correctly classified 71% of fall Chinook stocks. Indian tribal land, human population and number of dams correctly classified 86 % of winter steelhead stocks. Coastal stocks presented an average status of special concern and were associated with land use variables. Columbia Basin stocks averaged a moderate to high risk of extinction status and were associated with dams, wild and scenic rivers, and land use variables. Results between status of salmon and anthropogenic variables can be used to prioritize action towards salmon recovery.
Education, training, and practice among nordic neuropsychologists. Results from a professional practices survey

Abstract Objective: To investigate sociodemographic characteristics, clinical and academic training, work setting and salary, clinical activities, and salary and job satisfaction among practicing neuropsychologists in four Nordic countries. Methods: 890 neuropsychologists from Denmark, Finland, Norway, and Sweden participated in an internet-based survey between December 2013 and June 2015. Results: Three-fourths (76%) of the participants were women, with a mean age of 47 years (range 24–79). In the total sample, 11% earned a PhD and 42% were approved as specialists in neuropsychology (equivalent to board certification in the U.S.). Approximately 72% worked full-time, and only 1% were unemployed. Of the participants, 66% worked in a hospital setting, and 93% had conducted neuropsychological assessments during the last year. Attention deficit hyperactivity disorder, learning disability, and intellectual disability were the most common conditions seen by neuropsychologists. A mean income of 53,277 Euros was found. Neuropsychologists expressed greater job satisfaction than income satisfaction. Significant differences were found between the Nordic countries. Finnish neuropsychologists were younger and worked more hours every week. Fewer Swedish neuropsychologists had obtained specialist approval and fewer worked full-time in neuropsychology positions. Danish and Norwegian neuropsychologists earned more money than their Nordic colleagues. Conclusion: This is the first professional practice survey of Nordic neuropsychologists to provide information about sociodemographic characteristics and work setting factors. Despite the well-established guidelines for academic and clinical education, there are relevant differences between the Nordic countries. The results of the study offer guidance for refining the development of organized and highly functioning neuropsychological specialty practices in Nordic countries.
Domestic Debt Sustainability and Private Sector in Nigeria: Implications on Employment

A strand of literature supported sourcing of fund internally via debt relative to foreign debt. The principal and interest on such internal debt is a reinvestment into the economy which would frequently have a chain investment effects. This study investigates the domestic debt sustainability level, crowding out effect and its implication on employment in Nigeria. Through the application of Maastricht Treaty Indicators, it was revealed that the domestic debt level in Nigeria is not sustainable. The long-run equation, using employment as the dependent variable showed that there is a negative relationship with domestic debt, employment, aggregate output and credit to private. The correlation analysis shows that aggregate output has a negative relationship with employment and credit to the private sector. The findings were in line with previous studies that emphasised the need for broad-based growth in Nigeria. The implications of the result showed that the gradual increase in domestic debt in Nigeria has a crowding-effect on the private investment which had resulted in negative implications on employment generation through the private sector. Hence, the study recommended the need for a proper channel of investment through domestic debt with the aim to increase the productive capacity of the economy, Among others.
Cam and pincer femoroacetabular impingement: CT findings of features resembling femoroacetabular impingement in a young population without symptoms.

OBJECTIVE The purpose of this study was to use CT to determine the presence of radiologic parameters associated with cam and pincer femoroacetabular impingement (FAI) in a young population without symptoms. MATERIALS AND METHODS A retrospective review of 50 patients (age range, 20-40 years) with no current or previous hip disorder who underwent CT of the abdomen and pelvis was conducted. Multiplanar images were reformatted with a soft-tissue and bone algorithm and assessed for the presence of parameters associated with FAI; alpha angle greater than 55°, femoral head-neck offset less than 8 mm, angle of acetabular version less than 15°, lateral center edge angle greater than 40°, acetabular index less than 0°, pistol-grip deformity, acetabular crossover, and prominent posterior wall signs. RESULTS At least one abnormal parameter was present in 66% of joints, and two or more abnormal parameters were present in 29% of joints. In seven patients the findings were bilateral. Parameters of mixed morphologic characteristics (cam and pincer) were found in 22% of joints. In side-by-side comparison, high alpha angles were seen in 36 joints measured in the radial plane compared with only three joints measured in the axial oblique plane. CONCLUSION The CT finding of FAI-like features was made with high frequency in a young symptom-free population. Cutoff values for defining morphologic abnormalities associated with FAI may have been set too low in the current literature. Alpha angle measurements in the radial plane may be a more accurate quantitative assessment of asphericity of the femoral head-neck junction than are measurements in the axial oblique plane.
The Effect of Existing Knowledge Assets on Inbound/Outbound Disruptive Innovation

Innovation is an essential key factor in the technology development history. Past research on innovation focused more on the innovation behavior of technology, but seldom described knowledge assets which also influence innovation behavior greatly. The effect of knowledge assets attribute and result on disruptive innovation is therefore regarded as the research topic in this study, where disruptive innovation is divided into outbound and inbound to combine combination-embeddednessandmajor business specificityof knowledge assets as the research model. Manufacturing enterprises in China are proceeded the questionnaire survey, and 173 valid copies are collected. The empirical analysis shows that combination-embeddedness of knowledge assets presents significantly positive effects on major business specificity and outbound innovationof an enterprise but reveals remarkably negative effects on inbound innovation. Enterprises are suggested to constantly accumulate knowledge assets with low major business specificity before disruptive innovation in order to reduce ineffective inbound innovation.
Relationship between acute insulin response and vitamin K intake in healthy young male volunteers.

To evaluate the effects of vitamin K (VK) on pancreatic function, especially on acute insulin response, 25 healthy young male volunteers were given an oral load of 75 g of glucose, and their mean daily VK intake was estimated by a one-week food check list. After excluding low (<20) and high (> or =25) body mass index (BMI) subjects, the remaining 16 participants were divided into three semi-equal groups according to VK intake. Blood VK status of the low VK intake group tended to be poorer than that of the high intake group (median of 5 samples: prothrombin time; 12.5 vs 12.2s and protein-induced VK absence-factor-II; 23 vs 15 mAU/ml), but fasting plasma glucose status was not markedly different between both groups: [plasma glucose (PG); 87 vs 86 mg/dl, immunoreactive insulin (IRI); 6.7 vs 5.3 microU/ml, HbA1c; 4.8 vs 4.9%]. However, at 30 min after glucose loading, PG of the low VK intake group tended to be higher than those of the high intake group (160 vs 145 mg/dl) and IRI was lower (36.1 vs 52.3 microU/ml). Insulinogenic index (incremental IRI/incremental PG, 0-30 min) of the low VK intake group was significantly lower than that of the high intake group (0.4 vs 0.9). These results suggested that VK may play an important role on the acute insulin response in glucose tolerance.