Miracle-dz/UniFAR-FTUs huggingface dataset:
MicroRNA Expression Profiling in Psoriatic Arthritis

Background Psoriatic arthritis (PsA) is an inflammatory arthritis, characterized by bone erosions and new bone formation. MicroRNAs (miRNAs) are key regulators of the immune responses. Differential expression of miRNAs has been reported in several inflammatory autoimmune diseases; however, their role in PsA is not fully elucidated. We aimed to identify miRNA expression signatures associated with PsA and to investigate their potential implication in the disease pathogenesis. Methods miRNA microarray was performed in blood cells of PsA patients and healthy controls. miRNA pathway analyses were performed and the global miRNA profiling was combined with transcriptome data in PsA. Deregulation of selected miRNAs was validated by real-time PCR. Results We identified specific miRNA signatures associated with PsA patients with active disease. These miRNAs target pathways relevant in PsA, such as TNF, MAPK, and WNT signaling cascades. Network analysis revealed several miRNAs regulating highly connected genes within the PsA transcriptome. miR-126-3p was the most downregulated miRNA in active patients. Noteworthy, miR-126 overexpression induced a decreased expression of genes implicated in PsA. Conclusions This study sheds light on some epigenetic aspects of PsA identifying specific miRNAs, which may represent promising candidates as biomarkers and/or for the design of novel therapeutic strategies in PsA.
Association of estrogen receptor alpha gene polymorphisms with the risk , therapeutic outcome and prognosis of ADT-resistant prostate cancer in Chinese Han population

Estrogen receptor alpha (ESRα) gene expresses in prostate stromal cells and may associate with prostate cancer risk, while the relationship between ESRα polymorphisms and therapeutic outcome as well as prognosis of patients with prostate cancer in Chinese Han population has not been clarified. Genotypes of rs2234693 and rs9340799 in ESRα gene were detected in 168 ADT-resistant patients with prostate cancer and 220 healthy controls by PCR-RFLP. The associations of these polymorphisms with the risk, object response rate (ORR), disease control rate (DCR) and progression free survival (PFS) of prostate cancer were analyzed by chi-square test, KaplanMeier method and log-rank test. The distributions of rs2234693 and rs9340799 genotypes in patients and controls were significantly difference (all P<0.05). ORR was significantly higher in TT genotype of rs2234693 (X2=7.288, P=0.026) or GG genotype of rs9340799 (X2=9.118, P=0.010) carriers. DCR was no significantly difference among each genotypes (rs2234693: X2=4.541, P=0.103; rs9340799: X2=5.063, P=0.080). Median PFS (mPFS) in T-allele of rs2234693 carriers were 1.33 folds higher than CC carriers (Log rank P<0.05), while mPFS in combined cohort of GA+AA of rs9340799 was 2 folds higher than GG carriers (Log rank P<0.05). Stratified by Gleason score, the mPFS in CT and the combined cohort of CT+TT of rs2234693 carriers were 1.5 folders higher than that in CC (Log rank P<0.05) carried patients with lower (≤6) Gleason score. The polymorphisms rs2234693 and rs9340799 in ESRα gene were associated with the therapeutic outcome and short-term prognosis of patients with ADT-resistant prostate cancer in Chinese Han population, and could be considered a valuable biomarker for survival.
Contralateral Suppression of DPOAEs in Mice after Ouabain Treatment

Medial olivocochlear (MOC) efferent feedback is suggested to protect the ear from acoustic injury and to increase its ability to discriminate sounds against a noisy background. We investigated whether type II spiral ganglion neurons participate in the contralateral suppression of the MOC reflex. The application of ouabain to the round window of the mouse cochlea selectively induced the apoptosis of the type I spiral ganglion neurons, left the peripherin-immunopositive type II spiral ganglion neurons intact, and did not affect outer hairs, as evidenced by the maintenance of the distorted product otoacoustic emissions (DPOAEs). With the ouabain treatment, the threshold of the auditory brainstem response increased significantly and the amplitude of wave I decreased significantly in the ouabain-treated ears, consistent with the loss of type I neurons. Contralateral suppression was measured as reduction in the amplitude of the 2f1−f2 DPOAEs when noise was presented to the opposite ear. Despite the loss of all the type I spiral ganglion neurons, virtually, the amplitude of the contralateral suppression was not significantly different from the control when the suppressor noise was delivered to the treated cochlea. These results are consistent with the type II spiral ganglion neurons providing the sensory input driving contralateral suppression of the MOC reflex.
Diferencias salariales entre los trabajadores del sector público y del sector privado en Colombia en 1997

El presente articulo aplica el modelo de Roy para medir el tamano del diferencial salarial entre los trabajadores del sector publico y del sector privado en Colombia en 1997. La utilizacion de este modelo es importante porque permite eliminar el sesgo de seleccion de los coeficientes de las ecuaciones de Mincer que surgen cuando se estiman ecuaciones para las dos sectores separadamente: El modelo tambien permite hacer predicciones apropiadas del salario contrafactual que un trabajador ganaria en el otro sector. El diferencial salarial se mide con la descomposicion de Oaxaca, metodologia estandar en este tipo de estudios, y con una medida adicional diferencial promedio estimado. El estudio concluye que salvo para los trabajadores con estudios de posgrado, en el sector privado los salarios son inferiores a los del sector publico.
Training Gaussian Mixture Models at Scale via Coresets

How can we train a statistical mixture model on a massive data set? In this work we show how to construct coresets for mixtures of Gaussians. A coreset is a weighted subset of the data, which guarantees that models fitting the coreset also provide a good fit for the original data set. We show that, perhaps surprisingly, Gaussian mixtures admit coresets of size polynomial in dimension and the number of mixture components, while being independent of the data set size. Hence, one can harness computationally intensive algorithms to compute a good approximation on a significantly smaller data set. More importantly, such coresets can be efficiently constructed both in distributed and streaming settings and do not impose restrictions on the data generating process. Our results rely on a novel reduction of statistical estimation to problems in computational geometry and new combinatorial complexity results for mixtures of Gaussians. Empirical evaluation on several real-world data sets suggests that our coreset-based approach enables significant reduction in training-time with negligible approximation error.
Hamiltonian Variational Auto-Encoder

Variational Auto-Encoders (VAEs) have become very popular techniques to perform inference and learning in latent variable models as they allow us to leverage the rich representational power of neural networks to obtain flexible approximations of the posterior of latent variables as well as tight evidence lower bounds (ELBOs). Combined with stochastic variational inference, this provides a methodology scaling to large datasets. However, for this methodology to be practically efficient, it is necessary to obtain low-variance unbiased estimators of the ELBO and its gradients with respect to the parameters of interest. While the use of Markov chain Monte Carlo (MCMC) techniques such as Hamiltonian Monte Carlo (HMC) has been previously suggested to achieve this [23, 26], the proposed methods require specifying reverse kernels which have a large impact on performance. Additionally, the resulting unbiased estimator of the ELBO for most MCMC kernels is typically not amenable to the reparameterization trick. We show here how to optimally select reverse kernels in this setting and, by building upon Hamiltonian Importance Sampling (HIS) [17], we obtain a scheme that provides low-variance unbiased estimators of the ELBO and its gradients using the reparameterization trick. This allows us to develop a Hamiltonian Variational Auto-Encoder (HVAE). This method can be reinterpreted as a target-informed normalizing flow [20] which, within our context, only requires a few evaluations of the gradient of the sampled likelihood and trivial Jacobian calculations at each iteration.
Why Do Male Tree Weta Aggressively Evict Females from Galleries After Mating

The sexually dimorphic Wellington tree weta (Hemideina crassidens Blanchard) (Orthoptera: Anostostomatidae) is a harem-defending polygynous insect in which males use their enormous mandibles to fight conspecifics for access to harems residing in tree cavities (gallery). Tree weta ejaculates (spermatophores) do not include a nuptial meal (spermatophylax) to delay removal by females as in some ensiferan Orthoptera. Consequently, male tree weta are predicted to remain with their mates post-copula to ensure complete sperm transfer. Contrary to prediction, however, males forcibly eject females from the mating site (gallery) soon after copulation. Results suggest that forcible ejection occurs apparently because females consume the previous spermatophore if either the resident male or a rival initiates a subsequent copulation attempt. Thus, ejection appears to reduce the resident male’s risk that his ejaculate will be eaten and his mate will copulate with another male.
CXCR4/CXCL12 Signaling and Protumor Macrophages in Primary Tumors and Sentinel Lymph Nodes Are Involved in Luminal B Breast Cancer Progression

Luminal B breast cancers (BC) have a more aggressive behavior associated with a higher rate of tumor relapse and worse prognosis compared to luminal A tumors. In this study, we evaluated the involvement of specific epithelial-to-mesenchymal transition- (EMT-) and immune-related pathways in the dissemination of luminal B BC cells. The expression of 42 EMT- and immune-related genes was evaluated in matched sentinel lymph nodes (SLNs) analyzed by the one-step nucleic acid amplification assay (OSNA) and primary tumors of 40 luminal B BC patients by gene array and immunohistochemistry. The results were validated in an independent group of 150 luminal B tumors by immunohistochemistry and immunofluorescence and using gene expression data from 315 luminal B BC patients included in the Metabric dataset. We found that the expression of CXCR4 (p = 3.28E − 02) and CD163 (p = 6.92E − 03) was significantly upregulated in SLNs of recurrent luminal B BC patients. Luminal B primary tumors overexpressing CXCR4 were characterized by an increased expression of vimentin and a high content of CD163-positive macrophages. Bioinformatics analysis confirmed the correlation of CXCR4 with CXCL12, VIM, and CD163 expression and LN involvement. Our results suggest that the upregulation of the CXCR4/CXCL12 pathway and the presence of protumor macrophages in the primary tumor and SLNs sustain the aggressiveness of an important subgroup of luminal B BC.
Persistent Opioid Use Among Children, Adolescents, and Young Adults After Common Cleft Operations

Background: Surgical care represents an important source of opioid prescribing and chronic use, but rates of prolonged opioid use following pediatric procedures remain unclear. The authors describe the rates and risk factors for new persistent opioid use in patients after common cleft operations. Methods: The authors examined claims from the Truven Marketscan databases from January 1, 2010 to December 31, 2014. The authors included opioid-naive patients ages 8 to 25, who underwent 1 of 10 cleft-related procedures. Patients were considered opioid-naïve if they had no opioid prescription fills in the 11 months prior to the perioperative period. The authors obtained a random sample of age-matched, nonsurgical patients from the same dataset to be used as a control group. Included cleft patients had no procedural codes in the 6 months following surgery. All included patients filled an opioid prescription during the perioperative period, defined as 30 days before and 14 days after surgery. The primary outcome was new persistent opioid use, which is defined as continued opioid prescription fills between 90 and 180 days after the procedure. Results: This cohort included 2039 cleft patients and 2100 control patients. The incidence of new persistent opioid use following surgery was 4.4% and 0.1% in the control group. Higher odds of opioid use 3 months beyond surgery were associated with distractor placement (OR 5.34, CI 2.00–14.24, P = 0.001). Increasing age (OR 1.11, CI 1.04–1.17, P = 0.001) and presence of a gastrointestinal comorbidity (OR 7.37, CI 1.49–36.54, P = 0.014) were also associated with new persistent use. Conclusions: New persistent opioid use occurs after cleft-related procedures and could lead to chronic use in children, adolescents, and young adults.
Quality of Life among Saudi Diabetics

Aim of study: To assess QOL among Saudi diabetics and to identify the possible risk factors associated with lower QOL. Patients and Methods: This study comprised 400 diabetic patients attending the Diabetes Clinic at theUniversityDiabetesCenterinRiyadh. They were interviewed using the Audit of Diabetes Dependent QOL (ADDQOL). Results: Most diabetic patients (78.7%) had negative (i.e., unfavorable) ADDQOL scores. Diabetic patients' age, education and occupation were not significantly associated with their QOL. Female patients had significantly worse QOL than male patients (p = 0.026). Married patients had significantly worse QOL compared with non-married patients (p = 0.012). Patients with type 2 diabetes had significantly worse QOL than those with type 1 diabetes (p = 0.029). Duration of diabetes was not significant factors as regard their QOL, with the worst QOL among those with more than 20 years of diabetes. The degree of diabetes control was significantly and directly associated with QOL score (p i.e., neuropathy (p = 0.03), retinopathy (p
Obesity Effect on Children Hip and Knee Range of Motion

The aim of this study was to characterize the obesity effect on children knee and hip joint range of motion. A randomized controlled trial was performed with goniometry evaluation for hip flexion, extension, abduction, adduction, external and internal rotation, and knee flexion in fifty male children (20 obese and 30 non obese), with age ranging from 6 to 12 years old. The obesity effect was found to be non-uniform across the joint range of motion. In the obesity group, a statistically significant reduction in the range of motion of hip flexion and adduction, and knee flexion was observed; and also an increase in external rotation in the hip was observed. Conclusion: Obese and overweight children present alterations in hip and knee joints mobility when compared to eutrophic children. The obesity/overweight associated with factors previously described in the literature, such as joint overload, postural deviation and sedentariness may influence the musculoskeletal development and, consequently, the motor function.
Stevia Prevents Acute and Chronic Liver Injury Induced by Carbon Tetrachloride by Blocking Oxidative Stress through Nrf2 Upregulation

The effect of stevia on liver cirrhosis has not been previously investigated. In the present study, the antioxidant and anti-inflammatory properties of stevia leaves were studied in male Wistar rats with carbon tetrachloride- (CCl4-) induced acute and chronic liver damage. Acute and chronic liver damage induced oxidative stress, necrosis, and cholestasis, which were significantly ameliorated by stevia. Chronic CCl4 treatment resulted in liver cirrhosis, as evidenced by nodules of hepatocytes surrounded by thick bands of collagen and distortion of the hepatic architecture, and stevia significantly prevented these alterations. Subsequently, the underlying mechanism of action of the plant was analyzed. Our study for the first time shows that stevia upregulated Nrf2, thereby counteracting oxidative stress, and prevented necrosis and cholestasis through modulation of the main proinflammatory cytokines via NF-κB inhibition. These multitarget mechanisms led to the prevention of experimental cirrhosis. Given the reasonable safety profile of stevia, our results indicated that it may be useful for the clinical treatment of acute and chronic liver diseases.
Drug-drug interactions associated with length of stay and cost of hospitalization.

PURPOSE To evaluate the prevalence of drug-drug interactions (DDI) in prescriptions of hospitalized patients and to identify risk factors associated. METHODS A retrospective cross-sectional analysis of prescription data and medical records from a public hospital in Brazil was conducted to identify potential DDI. An inappropriate drug combination was identified and classified with a standard drug interaction source. The main diagnoses were classified with Charlson Comorbidity Index (CCI). Sex, age, polypharmacy and length of stay, among other variables, were correlated with the frequency of potential DDI. RESULTS The study included 589 patients and 3,585 prescriptions. Thirty-seven percent of the patients were exposed to at least one potential interaction during their stay in the hospital. The most frequent interacting pair was Digoxin+Furosemide (11%). In univariate analysis, several variables were associated with DDI, including sex, age, number of prescribed drugs, length and cost of hospitalization and CCI. Multivariate analysis showed that the adjusted odds of being prescribed a potential DDI among patients in polypharmacy was almost five-fold that of patients taking less than five drugs. Further, length of stay, CCI and cost of hospitalization were independently associated with DDI. CONCLUSION Analysis of prescription data found that a substantial number of potential DDI were identified. Results of this study indicate that DDI is associated with number of prescribed drugs, increased duration of stay in the hospital and cost, which suggest that DDI are a significant clinical and economic problem. Potential damage to patients could be avoided.
Factors Related to Community Mobilization and Continued Involvement in a Community-Based Effort To Enhance Adolescents' Sexual Behaviour

Purpose: This article describes and proposes a model of the factors that influenced community members' initial mobilization, continuing effort, or lack of involvement in a community based-intervention on adolescents' sexual health in Nova Scotia, Canada. Design: This study was conducted within the constructivist paradigm and guided by the principles of grounded theory. Methods: Factors related to community members' initial and continued involvement were explored using analyses of the contents of in-depth interviews and written documentation through pattern identification, clustering of conceptual groupings, identification of relationships between variables, constant comparisons, and theoretical memos. Subjects: Respondents included 14 participants, the 12 members of the Board of Directors and two paid staff (i.e., the project coordinator and the health centre nurse). Results: Specific personal, community-related, and organizational factors have influenced community members' involvement in the project. These factors were grouped into an explanatory model.
Spiral Waveguides on Germanium-on-Silicon Nitride Platform for Mid-IR Sensing Applications

Spiral waveguides on a new germanium-on-silicon nitride (GON) platform with a wide transparency and a large core-clad index contrast for mid-infrared (mid-IR) sensing applications are demonstrated. Spiral waveguide sensors with a low bending loss on this platform enable compact sensors for mid-IR absorption spectroscopy. A minimum volumetric concentration of 5% isopropanol (IPA) in an IPA–acetone mixture is measured. This detection limit is three times lower than the counterpart waveguide, fabricated on the regular germanium-on-silicon platform with similar propagation loss at 3.73 μm wavelength. This silicon-compatible GON sensor is promising for applications such as environmental studies, industrial leak detection, process control, medical breath analysis, and many more.
A dynamic ocean management tool to reduce bycatch and support sustainable fisheries

Dynamic management approaches protect endangered bycatch species but with much greater efficiency than existing static closures. Seafood is an essential source of protein for more than 3 billion people worldwide, yet bycatch of threatened species in capture fisheries remains a major impediment to fisheries sustainability. Management measures designed to reduce bycatch often result in significant economic losses and even fisheries closures. Static spatial management approaches can also be rendered ineffective by environmental variability and climate change, as productive habitats shift and introduce new interactions between human activities and protected species. We introduce a new multispecies and dynamic approach that uses daily satellite data to track ocean features and aligns scales of management, species movement, and fisheries. To accomplish this, we create species distribution models for one target species and three bycatch-sensitive species using both satellite telemetry and fisheries observer data. We then integrate species-specific probabilities of occurrence into a single predictive surface, weighing the contribution of each species by management concern. We find that dynamic closures could be 2 to 10 times smaller than existing static closures while still providing adequate protection of endangered nontarget species. Our results highlight the opportunity to implement near real-time management strategies that would both support economically viable fisheries and meet mandated conservation objectives in the face of changing ocean conditions. With recent advances in eco-informatics, dynamic management provides a new climate-ready approach to support sustainable fisheries.
Lumbar Hyperextension in Baseball Pitching: A Potential Cause of Spondylolysis.

Symptomatic spondylolysis/spondylolisthesis is thought to be caused by repetitive lumbar extension. About 8.9% of baseball pitchers that experience back pain will be diagnosed with spondylolysis. Therefore, this study aims to identify and quantify lumbar extension experienced during baseball pitching. It was hypothesized that young pitchers would exhibit less lumbar extension than older pitchers. A total of 187 healthy pitchers were divided into 3 age groups: youth, adolescent, and college. Kinematic data were collected at 250 Hz using a 3-D motion capture system. Lumbar motion was calculated as the difference between upper thoracic motion and pelvic motion over the pitching cycle. Lumbar "hyperextension" was defined as ≥20° past neutral. College pitchers had significantly greater lumbar extension compared with youth and adolescent pitchers at the point of maximum external rotation of the glenohumeral joint during the pitch cycle (-25° [13°], P = .04). For all age groups, lumbar hyperextension was present during the first 66% of the pitch cycle. Most pitchers spent 45% of pitch cycle in ≥30° of lumbar extension. Understanding that lumbar extension and hyperextension are components of the complex, multiplanar motions of the spine associated with baseball pitching can potentially help in both the prevention and management of symptomatic spondylolysis/spondylolisthesis.