Miracle-dz/UniFAR-FTUs huggingface dataset:
Introduction to Pre-Sampling Inference II

This paper describes a solution to survey sampling estimation problems that result from common sample design practices and from inadequate sample design control. These problems tend to magnify the variance of probability expansion estimators based on those designs – in particular, the Combined Ratio Estimator. Examples occur in flow sampling where a sampling frame and its design parameters are usually not available until after the universe has been sampled. Even when sample design parameters are available in timely fashion, generally accepted sample design practices can also cause unnecessarily large sampling error in the design based Combined Ratio Estimator. For these reasons, efficient design based strategies are a serious concern.
Transient and Attractor Dynamics in Models for Odor Discrimination

Understanding how sensory information is encoded and decoded in the brain is a fundamental challenge in neuroscience. The honeybee antennal lobe (AL) provides an ideal system to study the olfactory system because it is anatomically and genetically simpler than the olfactory bulb (OB) of mammals. While anatomical structures within the AL are relatively well known, their functional roles in sensory processing remain poorly understood. Processing in this network transforms the sensory input to give rise to dynamic spatiotemporal patterns that can be measured in the projection neurons (PNs) that provide output to other brain centers. Several studies showed that the dynamic processing in the AL may serve to decorrelate sensory representations through early transients rather than by reaching a stable attractor. Therefore, studying the transients and attractors in the given dynamical systems will be useful to better understand the olfactory system. A primary goal of this thesis is to develop and analyze a mathematical model for this olfactory system. This will help to better understand the mechanisms underlying spatiotemporal firing patterns in the AL. In the previous published papers, my coauthors and I analyzed biophysical excitatory-inhibitory neuronal network models. These models have been implicated in the generation of sleep rhythms, Parkinsonian tremor, sensory processing within the OB and AL. While this type of network arises in many important regions throughout the central nervous systems, rigorous
The Semantic Approach and Its Application to Evolutionary Theory

In this talk I do three things. First, I review what I take to be fruitful applications of the semantic view of theory structure to evolutionary theory. Second, I list and correct three common misunderstandings about the semantic view. Third, I evaluate the weaknesses and strengths of Horan's paper in this symposium. Specifically, I argue that the criticisms leveled against the semantic view by Horan are inappropriate because they incorporate some basic misconceptions about the semantic view itself.
Vehicle Color Recognition in The Surveillance with DeepConvolutional Neural Networks

Vehicle information extraction is the key means in Intelligent Transportation System (ITS). Color plays an important role in vehicle recognition. The main challenge of vehicle color recognition is to find the dominant color. In this paper, we propose a color recognition method using convolutional neural network. We train the classifier with the network structure ‘NIN’ to increase the classification accuracy. The experiments are validated on our dataset and extra data, which are collected from city surveillance equipment. The proposed method outperforms other competing color recognition methods.
Mcp-1 And App Involvement Of Glial Differentiation And Migration Of Neuroprogenitor Cells 2009

Neuroprogenitor cells are an important resource because of their potential to replace damaged cells in the brain caused by trauma and disease. It is of great importance to better understand which factors influence the differentiation and migration of these cells. Previously it has been reported that neuroprogenitor cells undergoing apoptotic stress have increased levels of Amyloid precursor protein (APP) and increased APP expression results in glial differentiation. APP activity was also shown to be required for staurosporine induced glial differentiation of neuroprogenitor cells. Monocyte chemoattractant protein-1 (MCP-1) is a chemokine that is expressed during inflammatory. The binding of MCP-1 to its chemokine receptor induces expression of novel transcription factor MCP-1 induced protein (MCPIP). MCPIP expression subsequently leads to cell death. Previous studies have shown that pro apoptotic factors have the ability to induce neural differentiation. Therefore, we investigated if MCPIP expression leads to differentiation of NT2 neuroprogenitor cells. Results showed that MCPIP expression increased glial fibrillary acid protein expression and also caused distinct morphological changes, both indicative of glial differentiation. Similar results were observed with MCP-1 treatment. Interestingly, APP expression decreased in response to MCPIP. Instead, we found APP activity regulates expression of both MCP-1 and MCPIP. Furthermore, inhibition of either p38 MAPK or JAK signaling pathways significantly reduced APP’s effect on MCP-1 and MCPIP. These data demonstrate the role APP has in glial differentiation of NT2 cells through MCP-1/MCPIP signaling. It is possible that increased APP expression after CNS injury could play a
Modeling Non-response Adjustment Factors

The most common method of adjustment for unit nonresponse is weighting, where respondents and nonrespondents are classified into adjustment cells based on some covariates known for all units in the sample, and a nonresponse adjustment factor is computed for all responding cases in each cell proportional to the inverse of the response rate in the cell. (Little, 1982; Little, 1986; Little, 1988) The estimated response rates depend on the overall cell structure.
The impact of venture capital financing on the survival of IPO firms

We analyze the impact of venture capital involvement on the survival time of French Initial Public Offerings (IPO) during the period 1996-2006. We examine the link between the survival time of IPO companies, and several proxies for the quality of venture capitalist financing. Our results show that, taken as a whole, venture capital financing has a negative impact on firm survival. However, the quality of venture capitalist monitoring, measured by the duration of their investment before the IPO, enhances company survival
Exploration of dyslipidemia prevalence and its risk factors in a coastal city of China : a population-based cross-sectional study

Compared with inland inhabitants, coastal area residents have commonly owned specific customs that have been associated with dyslipidemia occurrence. However, few studies have been conducted on the field of dyslipidemia in coastal areas of China. Therefore, the present comprehensive field investigation was conducted in Ningbo, a coastal city located in the Southeast of China, aiming to explore the prevalence of dyslipidemia and its risk factors among residents aged 15-74 years. In this population-based cross-sectional study, a representative sample of 5,280 permanent participants was obtained. All selected participants were required to finish three items, including face-to-face questionnaires, physical indicator measurements, and blood specimen collection. Prevalence of dyslipidemia was 29.86% in this study. Male group and rural residents had a significantly higher risk for occurrence of dyslipidemia (male 36.55% vs female 24.32%; rural 31.90% vs urban 28.18%). Moreover, dyslipidemia prevalence presented an obvious upward trend with increasing age. Multivariate logistic regression analysis indicated that risk factors associated with dyslipidemia in diverse genders were inconsistent. For males, current smoking, diabetes patients, and residents with high BMIs were easily susceptible to occurrence of dyslipidemia. For females, hypertension patients and subjects with central obesity were more likely to suffer from dyslipidemia. Present results revealed that almost one third of the residents suffered from dyslipidemia in Ningbo City. Targeted interventions, such as controlling risk factors and strengthening dyslipidemia screening, should be conducted to prevent and control dyslipidemia.
From Novelty to Necessity

Abstract Handheld computers are quickly becoming a ubiquitous tool in medicine. Factors that have spurred the rapid adoption of this technology in medicine include convenience and ease of use, mobility, and the enormous library of medical applications now available. Health sciences libraries in both hospitals and academic medical centers are actively promoting and supporting PDAs as a natural extension of their services. Medical libraries have quickly adopted this technology to deliver medical information in a non-traditional way. This paper discusses approaches being used to incorporate PDAs into library services and examines the impact of those approaches on the medical reference librarian.
Title : In Vitro Chemoresistance and Chemosensitivity Assays

Professional Institutional Original Effective Date: February 21, 2003 Original Effective Date: October 20, 2011 Revision Date(s): September 20, 2011; June 29, 2012; September 25, 2013; December 14, 2015; January 18, 2017; November 15, 2017; September 12, 2018 Revision Date(s): June 29, 2012; September 25, 2013; December 14, 2015; January 18, 2017; November 15, 2017; September 12, 2018 Current Effective Date: September 12, 2018 Current Effective Date: September 12, 2018
A Bispecific Antibody-Based Approach for Targeting Mesothelin in Triple Negative Breast Cancer

Triple negative breast cancers (TNBC) remain a major medical challenge due to poor prognosis and limited treatment options. Mesothelin is a glycosyl-phosphatidyl inositol-linked membrane protein with restricted normal expression and high level expression in a large proportion of TNBC, thus qualifying as an attractive target. Its overexpression in breast tumors has been recently correlated with a decreased disease-free survival and an increase of distant metastases. The objective of the study was to investigate the relevance of a bispecific antibody-based immunotherapy approach through mesothelin targeting and CD16 engagement using a Fab-like bispecific format (MesobsFab). Using two TNBC cell lines with different level of surface mesothelin and epithelial/mesenchymal phenotypes, we showed that, in vitro, MesobsFab promotes the recruitment and penetration of NK cells into tumor spheroids, induces potent dose-dependent cell-mediated cytotoxicity of mesothelin-positive tumor cells, cytokine secretion, and decreases cell invasiveness. MesobsFab was able to induce cytotoxicity in resting human peripheral blood mononuclear cells (PBMC), mainly through its NK cells-mediated antibody dependent cell cytotoxicity (ADCC) activity. In vivo, the anti-tumor effect of MesobsFab depends upon a threshold of MSLN density on target cells. Collectively our data support mesothelin as a relevant therapeutic target for the subset of TNBC that overexpresses mesothelin characterized by a low overall and disease-free survival as well as the potential of MesobsFab as antibody-based immunotherapeutics.
An Asymmetrically Substituted Aliphatic Bis-Dithiolene Mono-Oxido Molybdenum(IV) Complex With Ester and Alcohol Functions as Structural and Functional Active Site Model of Molybdoenzymes

A MoIV mono-oxido bis-dithiolene complex, [MoO(mohdt)2]2− (mohdt = 1-methoxy-1-oxo-4-hydroxy-but-2-ene-2,3-bis-thiolate) was synthesized as a structural and functional model for molybdenum oxidoreductase enzymes of the DMSO reductase family. It was comprehensively characterized by inter alia various spectroscopic methods and employed as an oxygen atom transfer (OAT) catalyst. The ligand precursor of mohdt was readily prepared by a three-step synthesis starting from dimethyl-but-2-ynedioate. Crystallographic and 13C-NMR data support the rationale that by asymmetric substitution the electronic structure of the ene-dithio moiety can be fine-tuned. The MoIVO bis-dithiolene complex was obtained by in situ reaction of the de-protected ligand with the metal precursor complex trans-[MoO2(CN)4]4−. The catalytic oxygen atom transfer mediated by the complex was investigated by the model OAT reaction from DMSO to triphenylphosphine with the substrate transformation being monitored by 31P NMR spectroscopy. [MoO(mohdt)2]2− was found to be catalytically active reaching 93% conversion, albeit with a rather low reaction rate (reaction time 56 h). The observed overall catalytic activity is comparable to those of related complexes with aromatic dithiolene ligands despite the novel ligand being aliphatic in nature and originally perceived to perform more swiftly. The respective results are rationalized with respect to a potential intermolecular interaction between the hydroxyl and ester functions together with the electron-withdrawing functional groups of the dithiolene ligands of the molybdenum mono-oxido complex and equilibrium between the active monomeric MoIVO and MoVIO2 and the unreactive dimeric Mo2VO3 species.
Advance of Nano-Composite Electrospun Fibers in Periodontal Regeneration

Periodontitis is considered to be the main cause of tooth loss, which affects about 15% of the adult population around the world. Scaling and root-planning are the conventional treatments utilized to remove the contaminated tissue and bacteria, but eventually lead to the formation of a poor connection—long junctional epithelium. Therefore, regenerative therapies, such as guided tissue/bone regeneration (GTR/GBR) for periodontal regeneration have been attempted. GTR membranes, acting as scaffolds, create three-dimensional (3D) environment for the guiding of cell attachment, proliferation and differentiation, and play a significant role in periodontal regeneration. Nano-composite scaffolds based on electrospun nanofibers have gained great attention due to their ability to emulate natural extracellular matrix (ECM) that affects cell survival, attachment and reorganization. Promoted protein absorption, cellular reactions, activation of specific gene expression and intracellular signaling, and high surface area to volume ratio are also important properties of nanofibrous scaffolds. Moreover, several bioactive components, such as bioceramics and functional polymers can be easily blended into nanofibrous matrixes to regulate the physical-chemical-biological properties and regeneration abilities. Simultaneously, functional growth factors, proteins and drugs are also incorporated to regulate cellular reactions and even modify the local inflammatory microenvironment, which benefit periodontal regeneration and functional restoration. Herein, the progress of nano-composite electrospun fibers for periodontal regeneration is reviewed, including fabrication methods, compound types and processes, and surface modifications, etc. Significant proof-of-concept examples are utilized to illustrate the results of material characteristics, cellular interactions and periodontal regenerations. Finally, the existing limitations of nano-composite electrospun fibers and the development tendencies in future are also discussed.
Nitric Oxide Dismutase (nod) Genes as a Functional Marker for the Diversity and Phylogeny of Methane-Driven Oxygenic Denitrifiers

Oxygenic denitrification represents a new route in reductive nitrogen turnover which differs from canonical denitrification in how nitric oxide (NO) is transformed into dinitrogen gas. Instead of NO reduction via N2O to N2, NO is proposed to be directly disproportionated into N2 and O2 in oxygenic denitrification, catalyzed by the putative NO dismutase (Nod). Although a high diversity of nod genes has been recovered from various environments, still little is known about the niche partitioning and ecophysiology of oxygenic denitrifiers. One constraint is that nod as a functional marker for oxygenic denitrifiers is not well established. To address this issue, we compared the diversity and phylogeny of nod, 16S rRNA and pmoA gene sequences of four NC10 enrichments that are capable of methane-driven oxygenic denitrification and one environmental sample. The phylogenies of nod, 16S rRNA and pmoA genes of these cultures were generally congruent. The diversity of NC10 bacteria inferred from different genes was also similar in each sample. A new set of NC10-specific nod primers was developed and used in qPCR. The abundance of NC10 bacteria inferred from nod genes was constantly lower than via 16S rRNA genes, but the difference was within one order of magnitude. These results suggest that nod is a suitable molecular marker for studying the diversity and phylogeny of methane-driven oxygenic denitrifiers, the further investigation of which may be of value to develop enhanced strategies for sustainable nitrogen or methane removal.
Dizziness and Convergence Insufficiency in Children: Screening and Management

Objective In children screened for dizziness with vergence disorders, we tested short and long term efficacy of orthoptic vergence training (OVT) and instructions to reduce screen usage. Methods Prospective study: Of the 179 children referred for vertigo or dizziness (over 3 years) with ophthalmological disorder as the only problem after complete oto-neuro-vestibular testing, 69 presented vergence insufficiency, and 49 accepted to participate in this study. 109 healthy children served as controls. All subjects had classic orthoptic evaluation and video binocular movement recordings during various oculomotor tasks. Patients were evaluated before OVT (M0), 3 months after the end of OVT (M3) and 9 months after the end of OVT (M9). Statistics compared orthoptic and oculomotor parameters between patients and controls over time with one-way ANCOVA, and mixed models, controlling for age and gender. Results Patients reported vertigo that was usually rotatory, lasting <15 min, associated with or alternating with headache (50%). Their exposure to small video screens and TV was intensive (∼3.6 h per day). At M0, all orthoptic and oculomotor parameters were statistically different in patients relative to controls (p < 0.0001) except for divergence. At M3, vertigo symptoms had disappeared in all of the patients, and all eye movement parameters improved significantly (p < 0.0001). At M9, this improvement remained stable or continued. Conclusion Vergence disorders (assessed by abnormal orthoptic and oculomotor parameters) can generate symptoms of dizziness in children. Orthoptic treatment and instruction to reduce screen usage has a significant and long term effect on vertigo symptoms as well as oculomotor performances. Dizzy children should be screened for vergence disorders. WHAT THIS STUDY ADDS Dizziness in children can be associated exclusively with insufficient convergence. Orthoptic training and instructions to reduce screen exposure made dizziness symptoms disappear and improved all eye movement parameters for 6 months. Vergence disorders should be screened for in dizzy children.
Blood Perfusion and Cellular Microstructural Changes Associated With Iron Deposition in Multiple Sclerosis Lesions

Background and Purpose: Susceptibility-weighted imaging (SWI) has emerged as a useful clinical tool in many neurological diseases including multiple sclerosis (MS). This study aims to investigate the relationship between SWI signal changes due to iron deposition in MS lesions and tissue blood perfusion and microstructural abnormalities to better understand their underlying histopathologies. Methods: Forty-six patients with relapsing remitting MS were recruited for this study. Conventional FLAIR, pre- and post-contrast T1-weighted imaging, SWI, diffusion tensor imaging (DTI), and dynamic susceptibility contrast (DSC) perfusion MRI were performed in these patients at 3T. The SWI was processed using both magnitude and phase information with one slice minimal intensity projection (mIP) and phase multiplication factor of 4. MS lesions were classified into 3 types based on their lesional signal appearance on SWI mIP relative to perilesional normal appearing white matter (peri-NAWM): Type-1: hypointense, Type-2: isointense, and Type-3: hyperintense lesions. The DTI and DSC MRI data were processed offline to generate DTI-derived mean diffusivity (MD) and fractional anisotropy (FA) maps, as well as DSC-derived cerebral blood flow (CBF) and cerebral blood volume (CBV) maps. Comparisons of diffusion and perfusion measurements between lesions and peri-NAWM, as well between different types of lesions, were performed. Results: A total of 137 lesions were identified on FLAIR in these patients that include 40 Type-1, 46 Type-2, and 51 Type-3 lesions according to their SWI intensity relative to peri-NAWM. All lesion types showed significant higher MD and lower FA compared to their peri-NAWM (P < 0.0001). Compared to Type-1 lesions (likely represent iron deposition), Type-2 lesions had significantly higher MD and lower FA (P < 0.001) as well as lower perfusion measurements (P < 0.05), while Type 3 lesions had significantly higher perfusion (P < 0.001) and lower FA (P < 0.05). Compared to Type-2, Type-3 lesions had higher perfusion (P < 0.0001) and marginally higher MD and lower FA (P < 0.05). Conclusion: The significant differences in diffusion and perfusion MRI metrics associated with MS lesions, that appear with different signal appearance on SWI, may help to identify the underlying destructive pathways of myelin and axons and their evolution related to inflammatory activities.
Poly-γ-Glutamic Acid Complexed With Alum Induces Cross-Protective Immunity of Pandemic H1N1 Vaccine

The use of a good vaccine adjuvant may induce a higher immunogenicity profile of vaccine antigens. Here, we developed a new adjuvant by combining poly-γ-glutamic acid (γ-PGA) with alum (PGA/Alum) and investigated its ability to enhance the immunogenicity and the cross-reactive efficacy of pandemic H1N1 (pH1N1) influenza vaccine antigen. PGA/Alum enhanced antigen delivery to draining lymph nodes and antigen-specific immunogenicity in mice using OVA as a model antigen. It also greatly increased OVA-specific antibody production, cytotoxic T lymphocyte (CTL) activity, and antibody-dependent cellular cytotoxicity (ADCC). These abilities of PGA/Alum improved the protective efficacy of pH1N1 vaccine antigen by increasing hemagglutination-inhibition titers, enhancing ADCC and CTL activity, and speeding viral clearance following homologous viral challenge. Importantly, the cross-protective efficacy of pH1N1 vaccine against heterologous viruses [A/Puerto Rico/8/34 (H1N1) and A/Hong Kong/1/1968 (H3N2)] was significantly enhanced by PGA/Alum, and cross-reactive ADCC and CTL activities were observed. Together, our results strongly suggest that PGA/Alum may be a promising vaccine adjuvant for preventing influenza and other infectious diseases.
OoNAC72, a NAC-Type Oxytropis ochrocephala Transcription Factor, Conferring Enhanced Drought and Salt Stress Tolerance in Arabidopsis

The NAC proteins form one of the largest families of plant-specific transcription factors (TFs) and play essential roles in developmental processes and stress responses. In this study, we characterized a NAC domain transcription factor, OoNAC72, from a legume Oxytropis ochrocephala. OoNAC72 was proved to be localized in the nuclei in tobacco lower epidermal cells and had transcriptional activation activity in yeast, confirming its transcription activity. OoNAC72 expression could be induced by drought, salinity and exogenous abscisic acid (ABA) in O. ochrocephala seedlings. Furthermore, over-expression of OoNAC72 driven by CaMV35S promoter in Arabidopsis resulted in ABA hypersensitivity and enhanced tolerance to drought and salt stresses during seed germination and post-germinative growth periods. In addition, over-expression of OoNAC72 enhanced the expression of stress-responsive genes such as RD29A, RD29B, RD26, LEA14, ANACOR19, ZAT10, PP2CA, and NCED3. These results highlight the important regulatory role of OoNAC72 in multiple abiotic stress tolerance, and may provide an underlying reason for the spread of O. ochrocephala.