Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of dietary supplementation with cod liver oil on monocyte thromboplastin synthesis, coagulation and fibrinolysis

Abstract. In a controlled trial 40 healthy persons (20 men and 20 women) were tested before and after a daily supplement with 25 ml cod liver oil for 8 weeks. The diet increased the eicosapentaenoic acid (20:5 n‐3) content in serum and monocytes four‐to five‐fold whereas the arachidonic acid (20:4 n‐6) content decreased 10–20% in both serum and monocytes. Stimulation of blood with a low concentration of lipopolysaccharides (LPS) revealed a 40% suppression of LPS‐induced thromboplastin synthesis in the monocytes after 8 weeks of CLO intake. In the same LPS stimulation system, men were found to generate significantly more thromboxane B2 than women (4.9 ng ml−1 versus 3.4 ng ml−1). After the CLO supplementation for 8 weeks the thromboxane B2 was reduced by a mean of 70% in women and 60% in men. Factor VII and fibrinogen appeared to be unaltered by CLO intake. Determination of whole blood clot lysis time and tissue plasminogen activator (t‐PA) did not indicate any significant influence of n‐3 fatty acids on fibrinolysis.
College Students’ Attitudes Toward Labor Unions: Implications for Employers

This study replicates and extends the research on pre-employment predictors of attitudes toward labor unions, which subsequently influence willingness to join a union. The impact of a number of factors including family socialization, parental union attitude, work beliefs (Marxist and humanistic), and college major (field of study) is assessed on college students’ attitudes toward labor unions. Selected demographic and attitudinal data were collected from a sample of 402 students representing several majors at a midsized Midwestern public university. The findings of the study strongly support the belief that family socialization and personal work beliefs are the most important predictors of college students’ attitudes toward labor unions. Unlike prior studies, the impact of race on college students’ attitudes toward labor unions was also assessed. Implications of these findings for employers and future research directions are also discussed.
Effect of subgingival scaling on systemic antibody responses to oral microorganisms

The effects of scaling and root planing treatment on systemic antibody responses were studied in patients with periodontal disease and in normal subjects. Immunoglobulin G antibody in serum to a battery of oral microorganisms was assessed in an enzyme-linked immunosorbent assay before and after treatment in 31 individuals. The majority (96%) of the diseased patients exhibited elevated antibody to one or more of the microorganisms before the scaling regime. Significant increases in antibody levels in serum were noted in 16 of 19 patients after scaling, whereas only 2 of 12 nonscaled subjects showed similar changes during monitoring intervals of up to 3 years. The bacterial specificities of the increases were found to differ among the patients; however, a significant correlation to preexisting elevated antibody levels was observed. Peak levels of responses were noted at approximately 2 to 4 months posttreatment; antibody returned to pretreatment levels by 8 to 12 months. The predominant organisms for which changes were noted included the black-pigmented Bacteroides spp. , Eikenella corrodens, Campylobacter concisus, and Actinobacillus actinomycetemcomitans. In 18 of 19 instances, the homologous microorganism was detected in the subgingival plaque when elevated antibody was present after treatment. These findings indicated that specific changes in host systemic responses accompany scaling and root planing treatment of periodontal disease patients. These alterations in the host response may provide an additional means by which successful therapy can be accomplished.
Trade unions and the non‐payment of wages in Russia

In the absence of slavery, worker and employer enter into an enforceable contractual agreement whereby the former is regularly paid by the latter. The systematic non‐payment of wages in Russia is the most tangible manifestation of the absence of the rule of law in that country and represents a potent obstacle to the development of effective trade unionism. However, the wage issue has to be set in the context of the wider malaise of non‐payment which exists, and for which central government must bear primary responsibility. This paper explores the dilemmas which this situation presents to the union movement and seeks to address the questions of what can and should the unions do about the situation? Because of the depth of the crisis inflicted on the economy by “shock therapy”, the answers are not to be found in the bankruptcy courts. While not abrogating their union functions, the trade unions must seek the satisfaction of realisable political demands.
Sex crimes and the new punitiveness.

In the last few years, new ways of punishing sex offenders have been introduced in many modern societies. However, these sanctions have a broader significance than this: they are part of a broader set of penal arrangements-directed at the criminal population as a whole-which represents a new punitiveness. This seems to be moving the direction of legal punishment beyond the established parameters that had hitherto been set for it in modern society. This had involved punishment becoming increasingly administered by penal bureaucracies, to the exclusion of the general public, being influenced by the opinion of penal experts, and becoming more tempered, consistent and purposeful in form. Sanctions that did not fit these criteria faded out of modern penality. The indeterminate prison sentence was introduced at its outer limits as a residual measure of control to be used against those offenders-frequently sex criminals-for whom the existing penal framework was thought inappropriate. Even so, by the 1970s, these special penal measures were falling into disuse. However, the new punitiveness has not only given new life to them, but has also led to the introduction of measures which seem to reverse or move beyond modernpenal parameters. The article argues that the reasons for these shifts lie in the profound economic and social changes that have taken place in Western societies over the course of the last two decades or so.
Ecological importance of sedges: a survey of the Australasian Cyperaceae genus Lepidosperma.

BACKGROUND Sedges (Cyperaceae) form an important ecological component of many ecosystems around the world. Sword and rapier sedges (genus Lepidosperma) are common and widespread components of the southern Australian and New Zealand floras, also occurring in New Caledonia, West Papua, Borneo, Malaysia and southern China. Sedge ecology is seldom studied and no comprehensive review of sedge ecology exists. Lepidosperma is unusual in the Cyperaceae with the majority of species occurring in dryland habitats. SCOPE Extensive review of ecological literature and field observations shows Lepidosperma species to be important components of many ecosystems, often dominating understorey and sedge-rich communities. For the first time, a detailed ecological review of a Cyperaceae genus is presented. CONCLUSIONS Lepidosperma species are long-lived perennials with significant abundance and persistence in the landscape. Speciation patterns in the genus are of considerable interest due to complex biogeographical patterns and a high degree of habitat specificity. Potential benefits exist for medicinal products identified from several Lepidosperma species. Over 178 organisms, including 26 mammals, 42 birds, six reptiles, five amphibians, eight arachnids, 75 insects, three crustaceans and 13 fungi, are found to be dependent on, or making use of, Lepidosperma species. A significant relationship exists between Lepidosperma species and the moth genus Elachista. Implications for the conservation and ecology of both sedges and associated species are discussed.
Cortical progenitor cells in the developing human telencephalon

Radial glial (RG) cells have been demonstrated to be a major neural progenitor cell type, but in the human fetal brain, neither their molecular nor their spatiotemporal characteristics are well known. We used glial and neuronal‐specific antibodies to determine the antigen characteristics and distribution of RG cells and other neuronal progenitors in the human brain during the first half of intrauterine development. Proliferating RG (4A4+) cells in the ventricular zone (VZ) showed clear caudorostral and ventrodorsal gradients, spreading from the spinal cord to the ventral rhombencephalon, at embryonic stages (4.5–5.5 gestational weeks [gw]). However, in the same embryo, other dividing cells expressed the neuronal marker SMI‐31 and were present throughout the entire CNS, including the rostral prosencephalon. At the beginning of cortical neurogenesis (6 gw), proliferating VZ cells labeled either with neuronal markers (SMI‐31, MAP2, β‐III‐tubulin), double‐labeled 4A4+/SMI‐31+ cells, or cells not labeled with these antibodies, were in close proximity to each other. At midgestation (17–24 gw), RG divisions were less frequent, but were spread throughout the entire cerebral cortex, including the subventricular and intermediate zones and the subpial granular layer. Several subtypes of RG were co‐labeled with vimentin and other glial markers (BLBP, GFAP, or GLAST) and quantified in vitro. In conclusion, the diversity of cortical progenitors in the human brain may, in part, explain the unique complexity of the human cerebral cortex. © 2005 Wiley‐Liss, Inc.
The National Front Vote in the 1977 GLC Elections: An Aggregate Data Analysis

The National Front is England's fourth largest party in terms of electoral support. The number of candidates it has fielded at local and national elections has increased at each successive election since it was founded in 1968. It has not, however, been extensively studied by academic researchers. Walker has provided a historical account of the development of the National Front. Scott has examined the activities and attitudes of one local branch. Nugent and King have compared it with earlier right-wing political organizations, particularly the British Union of Fascists. But rather less is known about the National Front's electoral support.
Farmer Premiums for the Voluntary Adoption of Conservation Plans

Abstract Programs that reimburse farmers for the cost of implementing more environmentally benign management practices are becoming increasingly popular in both the US and the EU. Utilizing the random utility and random profit difference approaches, the paper develops a theoretical model that explains why farmers may require a premium in excess of the decrease in profits to adopt a conservation plan, and may even require a premium in the case where adoption of the plan is associated with a mean increase in profits. This premium is estimated using a survey of farmers in conjunction with predictions of changes in production costs.
FLUOROSIS AS A PROBABLE CAUSE OF CHRONIC LAMENESS IN FREE RANGING EASTERN GREY KANGAROOS (MACROPUS GIGANTEUS)

Abstract A population of eastern grey kangaroos (Macropus giganteus) inhabiting heathland and farmland surrounding an aluminum smelter at Portland, Victoria, Australia, exhibited clinical signs of lameness. An investigation was undertaken to determine the cause of this lameness. Hematology, necropsy, histopathology, fecal egg count, total worm count, reproductive status, and the population age range were examined and failed to reveal any additional underlying disease state. The specific problem of lameness was addressed with bone histopathology, radiography, quantitative ultrasonography, microradiography, and multielement analysis of bone ash samples. The significant lesions observed were: osteophytosis of the distal tibia and fibula, tarsal bones, metatarsus IV, and proximal coccygeal vertebrae; osteopenia of the femur, tibia, and metatarsus IV; incisor enamel hypoplasia; stained, uneven, and abnormal teeth wear; abnormal bone matrix mineralization and mottling; increased bone density; and elevated bone fluoride levels. Microradiography of affected kangaroos exhibited “black osteons,” which are a known manifestation of fluorosis. Collectively, these lesions were consistent with a diagnosis of fluorosis.
RENEGOTIATION DESIGN WITH UNVERIFIABLE INFORMATION

This paper considers a buyer-seller relationship with observable but unverifiable investments and/or random utility parameters. In such situations, it is known that contract renegotiation may prevent the implementation of first-best outcomes. In this paper, we show however that efficient investments and optimal risk-sharing can typically be achieved provided the initial contract is able to monitor the ex post renegotiation process. Specifically, we focus on the following two features of renegotiation design. First, default options in case renegotiation breaks down; second, the allocation of all bargaining power to either contracting party. Moreover, we show that these two features can be obtained in standard Rubinstein bargaining games through contractual provisions, such as specific-performance clauses and penalties for delay (or, equivalently, financial "hostages" refundable without interest).
Low-level p53 expression changes transactivation rules and reveals superactivating sequences

Transcriptional activation by the tumor suppressor p53 is considered to depend on cellular level, although there are few systems where this dependence on cellular level of p53 has been directly addressed. Previously, we reported that transactivation from p53 targets was sensitive to both p53 amount and DNA sequence, with some sequences being responsive to much lower p53 levels than others when examined in yeast model systems or human cells. Because p53 is normally present at low levels and perturbations might lead to small increases, we examined transactivation under limiting p53. Unlike the positive relationship between transactivation and binding affinity from target sequences at high cellular levels of human p53 in yeast, no such relationship was found at low levels. However, transactivation in the yeast system and the torsional flexibility of target sequences were highly correlated, revealing a unique structural relationship between transcriptional function and sequence. Surprisingly, a few sequences supported high transactivation at low p53 levels in yeast or when transfected into human cells. On the basis of kinetic and flexibility analyses the “supertransactivation” property was due to low binding off rates of flexible target sites. Interestingly, a supertransactivation response element can differentiate transcriptional capacities of many breast cancer-associated p53 mutants. Overall, these studies, which are relevant to other transcription factors, address the extent to which transactivation properties of p53 target sequences are determined by their intrinsic physical properties and reveal unique rules of engagement of target sequences at low p53 levels.
Health promotion research literature in Europe 1995-2005.

BACKGROUND To undertake an overview of health promotion research in the EEA to inform the collaborative study-SPHERE (Strengthening Public Health Research in Europe). METHODS A 'filter' (search strategy) was used to search Medline and Embase for a 10-year period from 1995 to 2005. A 32% (6000) sample of the filter output was assessed for proportion constituting health promotion. Output was analysed by country, population, gross domestic product (GDP) and health need (disability-adjusted life years, DALYs). Disease prevention (screening and immunization) and health improvement papers were separately identified. The latter were classified by methodology, level of intervention and topic area. RESULTS 18,862 papers were identified. One-third was identified as health promotion (2206/6000, 36.7%) equivalent to 6935 (CI 6651-7230). Production varied: Nordic countries were highest producers per million population; the UK the largest net producer. There was a weak relationship between health promotion publication and population size (r(2) = 0.38); a weak inverse relationship with relative health (DALYs per million population) (r(2) = 0.07) and a slightly stronger relationship with GDP (r(2) = 0.45). Twenty-eight percent (626/2206) of the papers identified were disease prevention (screening and immunization). The largest topic areas of the remainder (1580) were diet and exercise, smoking and tobacco, and cardiovascular disease reduction. Accidents and violence, alcohol and mental health each accounted for <5% of total output. Intervention studies were a minority; with less aimed at the regional/national or policy or legal and fiscal levels. CONCLUSION Health promotion research production varies across Europe. Research commissioning should stress interventional and policy level research.
Symptoms, Spirometry, and Serum Antibody Concentrations Among Compost Workers Exposed to Organic Dust

Work-related symptoms and diseases of 190 currently exposed compost workers, 59 former compost workers, and 38 nonexposed control subjects were investigated in a cross-sectional study. Using a standardized questionnaire, participants were asked for work-related symptoms, exposures to bioaerosols, atopic diseases, and smoking habits. The subjects underwent a physical examination and a lung function test. In addition, total immunoglobulin (Ig) E, IgE specific to environmental allergens and moulds, and IgG specific to molds and actinomycetes were quantified. Compared to controls, compost workers suffered more often from cough and irritation of the eyes in terms of mucosal membrane irritation (MMI). Former compost workers reported similar work-related complaints, but most MMI symptoms had improved after termination of bioaerosol exposure. In contrast, cough and dyspnea persisted, indicating a chronic process. Lung function parameters of compost workers were within the reference ranges. Nevertheless, forced vital capacity (FVC) was significantly lower than for controls. Specific IgE to environmental allergens and molds was positive in 25.3% and 7.4%, respectively, of currently exposed compost workers. There were no marked differences in IgE and IgG concentrations among the three groups. Compost workers suffered with a higher frequency from cough and MMI symptoms. The findings that MMI symptoms improved in former compost workers after leaving the job confirmed the association with bioaerosol exposure. Further, the reduced FVC may be produced by this exposure. There was no higher frequency of mold sensitization in the group of compost workers compared to controls, which may be an indication of a healthy worker survivor effect.
UK Growth and Productivity in an International Perspective: Evidence from EU KLEMS

The productivity performance of the UK relative to its major competitors has been a concern for much of the postwar period. There is a general perception that, in recent years, its position has improved, however, most work stops short of the period in question. Newly constructed data from the EU KLEMS productivity and growth accounts database provides an insight into UK productivity performance and that of its major competitors. This paper provides an overview of recent UK performance relative to France, Germany and the US and finds that the UK has seen a rise in output and employment growth since 1995. Growth has been particularly strong in ICT producing sectors and market service sectors. With this in mind, there are perhaps some grounds for optimism for the future of productivity growth in the UK.
Improved delay-dependent stability criteria for systems with nonlinear perturbations

This paper studies the delay-dependent robust stability for time-delay systems with nonlinear perturbations. A new method is proposed to estimate the upper bound of the derivative of Lyapunov functional without ignoring some useful terms. Improved delay-dependent stability criteria are established by taking into account the range for the time-delay. In addition, augmented Lyapunov functionals are introduced to derive less conservative delay-dependent stability conditions. Finally, numerical examples are given to demonstrate the effectiveness and the merits of the proposed method.
External succession and disruptive change: heirs-apparent, forced turnover and firm performance

In general, CEO succession is disruptive to an organization, and external succession is especially disruptive. We analyze the impact on firm performance of disruption caused by external succession. Although traditional analysis of the succession process has emphasized the importance of a smooth transition to minimize disruption, research on external succession has emphasized the benefits of bringing in an outsider to shake things up. We investigate the impact on firm performance of three factors that affect the extent of disruption in external succession: forced turnover, which is generally viewed as highly disruptive; prior appointment of an external successor as an outside heir, in order to reduce disruption; and prior appointment as an outside heir with a public promise of becoming CEO. The results suggest that disruption in the form of forced turnover is associated with higher post-succession firm performance. The appointment of external successors as outside heirs first does not appear to be associated with improved firm performance. In addition, outside heir appointments with a public promise may be associated with somewhat worsened performance.
GIGAS CELL1, a Novel Negative Regulator of the Anaphase-Promoting Complex/Cyclosome, Is Required for Proper Mitotic Progression and Cell Fate Determination in Arabidopsis[W]

A novel plant-specific inhibitor of anaphase-promoting complex/cyclosome was identified from the gigas cell1 (gig1) mutation, which causes polyploidization of somatic cells due to ectopic endomitosis. This mutation also generated mixed-fate cells with both characters of guard cells and pavement cells, suggesting that GIG1 may have a role in cell fate determination, in addition to its role in proper mitotic progression. Increased cellular ploidy is widespread during developmental processes of multicellular organisms, especially in plants. Elevated ploidy levels are typically achieved either by endoreplication or endomitosis, which are often regarded as modified cell cycles that lack an M phase either entirely or partially. We identified GIGAS CELL1 (GIG1)/OMISSION OF SECOND DIVISION1 (OSD1) and established that mutation of this gene triggered ectopic endomitosis. On the other hand, it has been reported that a paralog of GIG1/OSD1, UV-INSENSITIVE4 (UVI4), negatively regulates endoreplication onset in Arabidopsis thaliana. We showed that GIG1/OSD1 and UVI4 encode novel plant-specific inhibitors of the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. These proteins physically interact with APC/C activators, CDC20/FZY and CDH1/FZR, in yeast two-hybrid assays. Overexpression of CDC20.1 and CCS52B/FZR3 differentially promoted ectopic endomitosis in gig1/osd1 and premature occurrence of endoreplication in uvi4. Our data suggest that GIG1/OSD1 and UVI4 may prevent an unscheduled increase in cellular ploidy by preferentially inhibiting APC/CCDC20 and APC/CFZR, respectively. Generation of cells with a mixed identity in gig1/osd1 further suggested that the APC/C may have an unexpected role for cell fate determination in addition to its role for proper mitotic progression.