Miracle-dz/UniFAR-FTUs huggingface dataset:
The health benefits of exercise therapy for patients with Down syndrome: A systematic review

Background Many patients with Down syndrome (PWDS) have poor cardiometabolic risk profiles, aerobic capacities and weak hypotonic muscles, primarily because of physical inactivity and poor diet. Objectives This study discusses the benefits of exercise therapy on body composition, aerobic capacity, muscle strength, proprioception and cardiometabolic profiles of PWDS. Methods A literature review using the Crossref metadatabase, following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), focusing on the period 2007-2018, was undertaken. Each record was judged adopting the modified Downs and Black Appraisal Scale. The literature investigation identified 15 701 records. Records were excluded if they were published before 2007, pertained to the impact of exercise on intellectual disabilities beyond Down syndrome or the impact of medical, pharmaceutical, nutrition and psychological interventions among PWDS and were published in languages besides English. Nineteen articles were synthesised into this commentary. Results PWDS have a heightened cardiometabolic risk profile and high oxidative stress associated with elevated insulin resistance, poor insulin sensitivity, atherosclerosis and hypertension. PWDS have low aerobic capacity (VO2max), peak heart rates, muscle strength, agility and balance. Regular physical activity is beneficial to improve their VO2max and muscle strength. Moreover, regular physical activity reduces lipid peroxidation and arterial cell wall damage, the pathogenesis of atheroma is limited. Conclusion Exercise therapy compliance seems to have a positive impact on the cardiometabolic risk profile, muscle strength and aerobic work capacity of PWDS. Nonetheless, additional vigorous experimental investigations are necessary to better understand the effect of exercise therapy on the aerobic, strength, proprioception and cardiometabolic risk profile of PWDS.
Validation of VARK questionnaire using gaze tracking data

—We use gaze data (fixation time on Areas of Interest, AoIs) collected while reading educational materials to validate the VARK (Visual Auditory Reading Kinaesthetic) questionnaire. We analyse the dependencies between four types of AoIs (Title, Text, Graph, Formula) and the VARK scores for sensory modalities using correlation and linear regression analysis. Our results show significant correlations for Formula – Reading, Text – Visual, and Title – Kinaesthetic dependencies. The results of research can be used for objective evaluation of learning style of subjects using gaze tracking technology.
Transcription factor TCP20 regulates peach bud endodormancy by inhibiting DAM5/DAM6 and interacting with ABF2

Abstract The dormancy-associated MADS-box (DAM) genes PpDAM5 and PpDAM6 have been shown to play important roles in bud endodormancy; however, their molecular regulatory mechanism in peach is unclear. In this study, by use of yeast one-hybrid screening, we isolated a TEOSINTE BRANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTOR transcription factor, PpTCP20, in the peach cultivar ‘Zhongyou 4’ (Prunus persica var. nectarina). The protein was localized in the nucleus and was capable of forming a homodimer. Electrophoretic mobility shift assays demonstrated that PpTCP20 binds to a GCCCR element in the promoters of PpDAM5 and PpDAM6, and transient dual luciferase experiments showed that PpTCP20 inhibited the expression of PpDAM5 and PpDAM6 as the period of the release of flower bud endodormancy approached. In addition, PpTCP20 interacted with PpABF2 to form heterodimers to regulate bud endodormancy, and the content of abscisic acid decreased with the release of endodormancy. PpTCP20 also inhibited expression of PpABF2 to regulate endodormancy. Taken together, our results suggest that PpTCP20 regulates peach flower bud endodormancy by negatively regulating the expression of PpDAM5 and PpDAM6, and by interacting with PpABF2, thus revealing a novel regulatory mechanism in a perennial deciduous tree.
Development and Pretesting of Risk-Based Mobile Multimedia Message Content for Young Adult Hookah Use

Background. Hookah is one of the most commonly used tobacco products among U.S. young adults due in part to widespread misperceptions that it is not harmful or addictive. There is growing evidence that hookah tobacco is associated with health harms and can lead to addiction. Research on interventions to address these misperceptions by communicating the harms and addictiveness of hookah use is needed. Aims. This study developed and pretested mobile multimedia message service (MMS) message content communicating the risks of hookah tobacco use to young adult hookah smokers. Method. Message content, delivery, and pretesting were tailored to participants’ risk beliefs, hookah use frequency, and responses to simulated text message prompts. Participants viewed 4 of 12 core MMS messages randomized within-subjects and completed postexposure measures of message receptivity and emotional response (e.g., worry). Results. The sample included 156 young adult (age 18-30 years) hookah smokers; 31% smoked hookah monthly and 69% weekly/daily. Prior to viewing messages, a majority endorsed beliefs reflecting misperceptions about the risks of hookah tobacco. Postexposure measures showed participants were receptive to the messages and the messages evoked emotional response. As anticipated, messages produced similar receptivity and there were few differences in emotional response between the messages tested. Discussion. Young adult hookah tobacco smokers were receptive to tailored mobile MMS messages and messages evoked emotional response, two critical precursors to behavior change. Conclusion. Findings indicate that research testing the efficacy of tailored MMS messaging as a strategy for reducing hookah tobacco use in young adults is warranted.
Health Disparities Among Exclusively Lesbian, Mostly Lesbian, and Bisexual Young Women.

Purpose: Health disparities have been identified between groups of diverse young sexual minority women (SMW) and heterosexual women. This approach may generate sufficient group sizes for statistical analyses but obscures important differences. Moreover, some young women may not identify as "lesbian" or "bisexual" but somewhere in between. This study examined health and sexual minority identity-specific outcomes among three groups of SMW-women who identify as "exclusively lesbian," "mostly lesbian," and "bisexual. " Methods: Participants were 990 young (18-30 years old) SMW (exclusively lesbian: n = 305, mostly lesbian: n = 133, bisexual: n = 552) who completed an online survey, including information about mental and physical health symptoms, hazardous drinking, and identity uncertainty. Those who reported alcohol use in the past 30 days responded to questions about their alcohol use and alcohol-related negative consequences. Results: Controlling for demographic differences, health outcomes varied significantly by identity. Mostly lesbian and bisexual women reported the most depression, anxiety, and physical health symptoms; mostly lesbian women reported the highest levels of hazardous drinking. Among those who reported drinking, mostly lesbian women drank the most frequently and reported the most alcohol-related consequences. Mostly lesbian women reported the most identity uncertainty. Conclusion: Mostly lesbian women were similar to bisexual women on several health outcomes. They appear unique, however, in drinking behavior and identity uncertainty. Collapsing across identities in health research may affect outcomes.
When mental illness and cancer collide: An investigation of the predictors of outcomes for cancer patients with a history of mental health problems

People with a serious mental health condition are no more likely to receive a diagnosis of cancer than the general population but fare more poorly in terms of outcomes. The current study investigated whether a background of mental health problems (measured by contact with mental health services and psychotropic medication) predicted treatment outcomes over and above demographic and medical confounds for cancer patients at Counties Manukau Health.
Women and the new paradigm of health and medicine

This paper argues that there is a 'new paradigm in health and medicine'. The biomedical model is being overlain by a psycho-socio-epidemio logical model. Many feminist writers demonstrated that a system of health care which was dominated by the biomedical model was especially damaging for women. However, a system which is underpinned by the psycho-socio-epidemiological model may also have some potentially detrimental consequences for women. Drawing on the concepts of 'risk', 'surveillance' and the 'rational self', this paper offers a critical analysis of health promotion—a core feature of the new paradigm—and concludes by setting out six key implications for women and health.
GC-MS ANALYSIS OF RUMEX VESICARIUS L.

The Gas chromatography-Mass spectrometry (GCMS) analysis of Rumex vesicarius L. was carried out in four solvents like ethyl acetate extract (EE), ethyl alcohol extract (EAE), chloroform extract (CE), and hexane extract (HE)) to identified the phytochemical constituents. In hexane 61 compounds, chloroform 56 compounds, ethyl alcohol 49 compounds and ethanol extract 45 compounds were identified.
Phenotypic Parent Selection Within a Khorasan Wheat Collection and Genetic Variation in Advanced Breeding Lines Derived by Hybridization With Durum Wheat

Tetraploid relatives of durum wheat (Triticum turgidum L. subsp. durum (Desf.) Husnot) represent an important reservoir of economically useful genes for development of new wheat cultivars. Two field experiments were conducted at Foggia (Italy), in the 2004 to 2006 and 2012 to 2015 growing seasons. In the first, 77 Khorasan wheat [T. turgidum subsp. turanicum (Jakubz.) Á. Löve & D. Löve] accessions from 23 countries of four geographic regions (Africa, Asia, Europe, and others) were evaluated to explore breeding opportunities. Seven agronomic traits were used to describe the diversity among the accessions: days to heading (HT), plant height (PH), grain yield (GY), specific weight (SW) as an indication of the density of the grain, 1000-grain weight (TGW), protein content, and gluten content. The total Shannon–Weaver diversity index was used to estimate phenotypic diversity, which ranged from monomorphic for PC (0.39) to highly polymorphic for TGW (0.67). A high level of total variation (87%) was attributed to the within-region diversity. The accessions grouped into six clusters, and seven elite accessions were selected as parents for crosses with durum wheat. In the second experiment, ten parents (seven Khorasan accessions and three durum wheat cultivars) and 790 F6 recombinant inbred lines (RILs) from the different T. durum × T. turgidum subsp. turanicum crosses were included to study genotypic and phenotypic variability of the same agronomic traits, plus the susceptibility index (SI) for disease. The genotypic coefficients of variation were lower than the phenotypic ones for all of the traits, which showed an environment effect on expression of these traits. High broad-sense heritability (h2 b > 86%) was recorded for all traits, and high h2 b coupled with high genetic gain as percentage of the mean (ΔG) was observed for HT, PH, GY, and SW, and for SI. This suggests that selection for these traits will provide good responses. Four principal components explained 70% of the total variation, and the genotypes were clustered into 20 groups. According to the results, some lines could be tested in varietal registration trials, and/or could be used as a significant breeding pool for durum wheat cultivar development in Mediterranean area.
DISABLEMENT IN CONTEXT: DO SOCIAL NETWORKS MODERATE THE IMPACT OF INCREASING FUNCTIONAL IMPAIRMENT ON WELL-BEING?

Abstract Objectives Findings on the health impact of moderate alcohol use in later-life have been discrepant. Unaddressed mechanisms of action and validity concerns may contribute to contrasting results. Several studies have demonstrated a beneficial relationship between moderate alcohol use and functional ability. Research is needed to identify mechanisms of action that explain this relationship, while employing methods to reduce common validity concerns in alcohol use research. This study examines social interaction and depressive symptoms as serial mediators in the relationship between moderate alcohol use and functional limitation in later-life. Method HRS data from 2012–2016 were utilized (n = 1,474); heavy drinkers, adults younger than 65, and respondents with inconsistent alcohol use from 2008 to 2016 were excluded. Hypotheses were evaluated using a longitudinal serial mediation model with bias-corrected bootstrapping. Results Results indicated that, in the context of demographic variables, medical burden, and previous functional limitation, the relationship between 2012 moderate alcohol use and 2016 reduced functional limitation is only present when considering the mediating effect of 2014 depressive symptoms as a single mediator, and 2012 social interaction and 2014 depressive symptoms as serial mediators, respectively (total effect model R 2=.167). Conclusions Data indicate that relationships between moderate drinking and reduced functional limitation are explained through increased social interaction and subsequent reduced depressive symptoms. Results identify social interaction as an accessible treatment target to address depressive symptoms and functional limitation, and support increased assessment of IADLs in adults experiencing depressive symptoms (and vice versa) to facilitate early treatment/prevention of functional and emotional decline.
Quality of Life People Living with HIV/AIDS and Its Characteristic from a VCT Centre in Indonesia

Background The quality of life (QoL) construct has also contributed to understanding the comprehension of factors involved in the existence of people infected by the HIV/AIDS. The objective of this study is to assess the quality of life (QoL) of people with HIV/AIDS (PLWHA) in Wonogiri District, Indonesia. Methods A cross-sectional study was conducted from September to November 2017. Convenience sampling method was employed to recruit 39 people living with HIV/AIDS (PLWHA) at Voluntary Counselling and Testing (VCT) of Wonogiri, Indonesia. Research data were collected using a self-administered questionnaire of WHOQOL-HIV BREF. The data were further analysed using a t-test and a Chi-square test, while linear regression was used to evaluate factors that correlate with the PLWHAs' quality of life. Results The results showed that the gross mean score of social relationships domain is 13.59; psychological domain is 13.31; environment domain is 13.28; spiritual/personal beliefs domainis 13.15; physical domain is 13.10; and level of independence domain is 13.77. The symptom of HIV is associated with quality of life (B = 7.611, β = 0.362, t = 2,046, p value = 0.049). Conclusion Healthcare provider should increase providerinitiated testing and counselling (PITC) to contracting group, high risk group, susceptible group, and the community. The PLWHA are recommended to actively participate in peer support groups (PSGs) so that they can improve their quality of life.
Including parents in inclusive practice: Supporting students with disabilities in higher education

Background While a number of research studies have endeavoured to understand students with disabilities’ experience in higher education and have recommended ways to effectively support student success, the role of parental support has been neglected. Many studies have been hampered by a limited understanding of students with disabilities and have, in particular, underestimated students’ ‘access to economic, social and cultural forms of capital’ that caring parents provide. Objectives This article seeks to explore students with disabilities’ experiences of parental support in the South African higher education context. The research question guiding this article is: What forms of economic, social and cultural capital do parents and extended families provide to students with disabilities to enable them to succeed in higher education? Method In-depth semi-structured individual and focus group interviews were conducted with 17 students with disabilities at two universities of technology. The interview transcripts were thematically analysed with a view to understanding Pierre Bourdieu’s forms of capital that parents provided. Results The study found that while parents are not always able to provide material support, they offered rich and varied forms of social and cultural capital that enabled students with disabilities’ academic success. Conclusion Given that parental support plays an important role in the success of students with disabilities, and this role changes as these students become more independent, this study recommends the need for universities to also pay more attention to involving parents in the education of the former. It is hoped that putting in place appropriate forms of parental involvement can create a conducive environment for universities to provide inclusive education holistically.
On the validity of single tests, two-test combinations and the full Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) in detecting patients with cognitive impairment

Background: The international standard to screen for cognitive impairment in multiple sclerosis (MS) is BICAMS (Brief International Cognitive Assessment for MS). However, with an application time of approximately 20 minutes, the battery might be too time consuming from a pragmatic perspective of a routine examination. Objectives: To examine the relative sensitivity and specificity of a BICAMS short version and its validity compared to the total battery. Methods: The German BICAMS version was applied comprising the Symbol Digit Modalities Test (SDMT), the Brief Visuospatial Memory Test–Revised (BVMT-R) and the Rey Auditory Verbal Learning Test (RAVLT; German VLMT). Single tests and two-test combinations were compared regarding conformity with the total battery. Results: Examining 1320 MS patients, the two-test combination of SDMT-BVMT-R was the most sensitive (92.7%) to impairment and showed the strongest agreement with the total battery (κ = 0.95). Performing binary logistic regression analyses, this combination was also validated by its association with employment status. Conclusion: Application of the total BICAMS battery should be the goal to strive for. However, in time-restricted clinical settings, the combined application of SDMT and BVMT-R is a recommendable alternative with an application time of 10 minutes, while single tests alone are not sufficiently sensitive.
The Effect of Oxygen Limitation on a Xylophagous Insect’s Heat Tolerance Is Influenced by Life-Stage Through Variation in Aerobic Scope and Respiratory Anatomy

Temperature has a profound impact on insect fitness and performance via metabolic, enzymatic or chemical reaction rate effects. However, oxygen availability can interact with these thermal responses in complex and often poorly understood ways, especially in hypoxia-adapted species. Here we test the hypothesis that thermal limits are reduced under low oxygen availability – such as might happen when key life-stages reside within plants – but also extend this test to attempt to explain that the magnitude of the effect of hypoxia depends on variation in key respiration-related parameters such as aerobic scope and respiratory morphology. Using two life-stages of a xylophagous cerambycid beetle, Cacosceles (Zelogenes) newmannii we assessed oxygen-limitation effects on metabolic performance and thermal limits. We complement these physiological assessments with high-resolution 3D (micro-computed tomography scan) morphometry in both life-stages. Results showed that although larvae and adults have similar critical thermal maxima (CTmax) under normoxia, hypoxia reduces metabolic rate in adults to a greater extent than it does in larvae, thus reducing aerobic scope in the former far more markedly. In separate experiments, we also show that adults defend a tracheal oxygen (critical) setpoint more consistently than do larvae, indicated by switching between discontinuous gas exchange cycles (DGC) and continuous respiratory patterns under experimentally manipulated oxygen levels. These effects can be explained by the fact that the volume of respiratory anatomy is positively correlated with body mass in adults but is apparently size-invariant in larvae. Thus, the two life-stages of C. newmannii display key differences in respiratory structure and function that can explain the magnitude of the effect of hypoxia on upper thermal limits.
Sickle cell anemia and β‐gene cluster haplotypes in Cuba

We have studied 91 patients with SS genotype, 44 children and 47 adults. Excluding the Cameroon and atypical haplotypes, the distribution in the children's sample exhibited 43% Benin, 38% Bantu, and 3% Senegal. In adults, the sample exhibited 46% Benin, 30% Bantu, and 9% Senegal (x2: 13.511, 2 df, P = 0.001). When the whole sample of 198 chromosomes (SS, SC, and S/βthal) is considered, we find that the βs chromosome is linked 51% to the Benin haplotype, 41% with the Bantu, and 8% with the Senegal. After adjusting for the different frequencies of βs in Africa, these numbers would predict the port of origin to be 16% from Atlantic West Africa, 37.3% from Central West Africa, and 46% from Bantu‐speaking Africa. This is in direct contradiction with the historical record that establishes a higher percentage from Bantu‐speaking Africa (55%) and a much lower percentage from Senegal (3.4%). The overall conclusions from these findings is that there is a loss of Bantu haplotypes in sickle cell syndromes in Cuba, particularly among adults, and that there is an excess of Senegal haplotype, also among adults. These differences might reflect the differential survival and severity of the sickle cell disease linked to these haplotypes. © 1995 Wiley‐Liss, Inc.
A Critical Review of the Sociology of Alternative Medicine: Research on Users, Practitioners and the Orthodoxy

The popularity of alternative therapies in the past two decades has been accompanied by a proliferation of sociological works investigating different aspects of this phenomenon.1,2 A major strand of the literature in ‘the sociology of alternative medicine’, which concerns three social actors: users of alternative therapies; practitioners of alternative therapies; and physicians (the orthodoxy). Research on users of alternative medicine has mainly investigated the causes of people’s use of these modalities and has focused on three questions: Why do people use alternative medicine? Why has alternative medicine become popular in recent times? and, What is the sequence of events that leads to alternative medicine use? Research on alternative practitioners has mainly investigated the issue of professionalization of these practitioners. Research on physicians has mainly investigated: physicians’ views on and professional relationships with alternative therapists; physicians’ views on the efficacy of alternative therapies; the orthodoxy’s views on the knowledge base of these therapeutic systems; and physicians who use alternative techniques. The article argues that a paucity of empirical research is a major weakness of the present state of the sociology of alternative medicine and thus several research possibilities are delineated. Its aim is to provide a critical review of the literature on each of the above topics and suggest future research possibilities.