Miracle-dz/UniFAR-FTUs huggingface dataset:
A influência da rede social da nutriz no aleitamento materno: o papel estratégico dos familiares e dos profissionais de saúde

The objective was to raise and classify scientific works on the influence of the social net of lactating mothers in the context of the breastfeeding. A bibliographical review was done in the main databases (MEDLINE, LILACS, SciELO), using as keywords: breastfeeding, weaning and family (and their versions in English and Spanish). Books, thesis, dissertations, and publications in international and national institutions were consulted (WHO, UNICEF, Ministry of Health). It could be observed that the actors that compose the social net of the lactating mothers can interfere in the decision of breastfeeding, through different extents, such as the encouragement/support to the initiative; reviewing the knowledge and cultural values; family tradition; and the cultivation of the indifference/discourage and the pressure exercised on the lactating mothers in relation to the form of feeding the child. In this way, it can infer on the need of the implementation of new health practices regarding to the care of this group. It is worth to highlight, the importance of the professionals to be qualified for the sensitive listening on the meaning of the nursing under the glance of the lactating mothers . Finally, it stands out the importance role of the social net of the lactating mothers, especially the family, for a successful breastfeeding.
Wastewater treatment plants release large amounts of extended-spectrum β-lactamase-producing Escherichia coli into the environment.

BACKGROUND The determinants of the spread of extended-spectrum β-lactamase-producing Escherichia coli (ESBLEC) in the community remain unclear. To evaluate its dissemination in the environment, we analyzed the ESBLEC population throughout an urban wastewater network. METHODS Samples were collected weekly, over a 10-week period, from 11 sites throughout the wastewater network of Besançon city (France). Total E. coli and ESBLEC loads were determined for each sample. As a control, we analyzed 51 clinical ESBLEC isolates collected at our hospital. We genotyped both environmental and clinical ESBLEC by pulsed-field gel electrophoresis and multilocus sequence typing and identified their blaESBL genes by sequencing. RESULTS The E. coli load was higher in urban wastewater than in hospital wastewater (7.5 × 10(5) vs 3.5 × 10(5) CFU/mL, respectively). ESBLEC was recovered from almost all the environmental samples and accounted for 0.3% of total E. coli in the untreated water upstream from the wastewater treatment plant (WWTP). The ESBLEC load was higher in hospital wastewater than in community wastewater (27 × 10(3) vs 0.8 × 10(3) CFU/mL, respectively). Treatment by the WWTP eliminated 98% and 94% of total E. coli and ESBLEC, respectively. The genotyping revealed considerable diversity within both environmental and clinical ESBLEC and the overrepresentation of some clonal complexes. Most of the sequence types displayed by the clinical isolates were also found in the environment. CTX-M enzymes were the most common enzymes whatever the origin of the isolates. CONCLUSIONS The treatment at the WWTP led to the relative enrichment of ESBLEC. We estimated that >600 billion of ESBLEC are released into the river Doubs daily and the sludge produced by the WWTP, used as fertilizer, contains 2.6 × 10(5) ESBLEC per gram.
A further evaluation of the ‘over-the-top’ technique for anterior cruciate ligament replacement in the dog

The ‘Over-the-Top’ Technique for anterior cruciate ligament replacement using the lateral third of the straight patellar ligament and fascia lata as a graft was used in 150 dogs (average weight 35 kg). Follow-up reports were obtained on 100 cases. The average recovery time was 12 weeks and a successful outcome was achieved in 91 per cent of cases.
Online social network acceptance: a social perspective

Purpose – Building upon studies of social psychology and information system literature, this study aims to propose and empirically test a research model that incorporates interpersonal motives (sociability and status) and hedonic motive (perceived enjoyment), and the three processes of social influence: compliance, identification and internalisation, to explain one's intention to use social network (SN) web sites.Design/methodology/approach – The data were obtained from an online survey of 274 SN web site users. Structural equation modelling analysis was used to validate the proposed model.Findings – The results indicate that social influence affects intention directly through the compliance process. Social influence, when exerted through the identification and internalization processes, affects intention indirectly via the two interpersonal motives (sociability and status) and perceived enjoyment. The two interpersonal motives affect intention indirectly via perceived enjoyment.Research limitations/impli.
Lipid levels and changes in body fat distribution in treatment-naive, HIV-1-Infected adults treated with rilpivirine or Efavirenz for 96 weeks in the ECHO and THRIVE trials.

BACKGROUND Pooled ECHO/THRIVE lipid and body fat data are presented from the ECHO (Efficacy Comparison in Treatment-Naïve, HIV-Infected Subjects of TMC278 and Efavirenz) and THRIVE (TMC278 Against HIV, in a Once-Daily Regimen Versus Efavirenz) trials. METHODS We assessed the 96-week effects on lipids, adverse events (AEs), and body fat distribution (dual-energy x-ray absorptiometry) of rilpivirine (RPV) and EFV plus 2 nucleoside/nucleotide reverse transcriptase inhibitors (N[t]RTIs) in treatment-naive adults infected with human immunodeficiency virus type 1 (HIV-1). RESULTS Rilpivirine produced minimal changes in total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides. Compared with RPV, EFV significantly (P < .001) increased lipid levels. Decreases in the TC/HDL-C ratio were similar with RPV and EFV. Background N[t]RTI affected RPV-induced lipid changes; all levels increased with zidovudine/lamivudine (3TC) and abacavir/3TC (except triglycerides, which were unchanged). With emtricitabine/tenofovir, levels of HDL-C were increased, TC and LDL-C were unchanged, and triglycerides were decreased. With EFV, lipid levels increased in each N[t]RTI subgroup (except triglycerides were unchanged with abacavir/3TC). Fewer (P < .001) RPV-treated patients than EFV-treated patients had TC, LDL-C, and triglyceride levels above National Cholesterol Education Program cutoffs. More RPV- than EFV-treated patients had HDL-C values below these cutoffs (P = .02). Dyslipidemia AEs were less common with RPV than with EFV. Similar proportions of patients had a ≥10% decrease in limb fat (16% with RPV and 17% with EFV). Limb fat was significantly (P < .001) increased to a similar extent (by 12% with RPV and 11% with EFV). At week 96, patients receiving zidovudine/3TC had lost limb fat, and those receiving emtricitabine/tenofovir had gained it. CONCLUSIONS Over the course of 96 weeks, RPV-based therapy was associated with lower increases in lipid parameters and fewer dyslipidemia AEs than EFV-based treatment. Body fat distribution changes were similar between treatments. The N[t]RTI regimen affected lipid and body fat distribution changes.
POLYNEURITIS FROM TRICRESYL PHOSPHATE

A type of paralysis involving thousands of cases throughout the continent, caused by a product new to medicine and evidently arising from a single source, is so unusual that its effects should be a matter of record. Such was the polyneuritis caused by tricresyl phosphate adulterating extract of jamaica ginger, which arose in epidemic form in many sections of the country, early in 1930. The use of jamaica ginger extract, at least in New England, had for many years been the first thought in many families in cases of gastric distress. Only comparatively recently has it come into more general use among alcoholic addicts as a substitute for, or in combination with, other substances containing alcohol. Had the adulteration with poison occurred in earlier generations before there were more modern remedies for gastric disturbances, it is probable that the type of patients becoming victims of this paralysis would have been
Enhancing Medication Adherence Through Communication and Informed Collaborative Choice

The failure of patients to adhere to medication is a significant problem in clinical medicine. In simple short-term acute care, as well as in complex longer term treatment for chronic illness, the medical prescription is ignored or followed incorrectly more than 40% of the time. Recent research on adherence points to the critical role played by a patient's knowledge and beliefs about the benefits (vs. costs and risks) and efficacy of adhering, as well as by his or her ability to overcome some practical social barriers. Long-term and particularly lifetime regimens require commitment and independent action on the part of the patient. PREPARED@ is a system that has recently been developed to standardize and categorize information about benefits versus costs and risks of treatment. In this system, providers and patients each bring their own expertise to bear on health care decisions. Communication of understandable information about the benefits versus costs of medication and of unambiguous details of the reg.
Paired‐pulse facilitation at recurrent Purkinje neuron synapses is independent of calbindin and parvalbumin during high‐frequency activation

• Endogenous Ca2+ binding proteins such as calbinding‐D28k (CB) and parvalbumin (PV) are considered important regulators of short‐term synaptic plasticity. • Cerebellar Purkinje neurons express large amounts of CB and PV and are laterally connected by inhibitory synapses that show paired‐pulse facilitation (PPF) during high‐frequency activation. • We report quantal synaptic release parameters of these synapses in wild‐type and in CB and PV knock‐out mice; evidence is provided that these synapses operate at nanodomain influx‐release coupling. • We find that PPF is independent of CB and PV, using a combination of paired electrophysiological recordings, synaptic Ca2+ imaging and numerical computer simulations. • Our results suggest that PPF during high‐frequency activation results from slow Ca2+ unbinding from the sensor for transmitter release, which is reminiscent of the ‘active Ca2+’ mechanism of PPF suggested by Katz and Miledi in 1968.
Financial services and the Internet - what does cyberspace mean for the financial services industry?

Financial services is undergoing a period of unprecedented change ‐ new products, new entrants, mergers and acquisitions, downsizing … and now another new delivery channel: the Internet. The performance attributes of the Internet are related to both the needs of consumers and the nature of financial services products. Suggests loans, cross‐border services, payments and “knowledge/advice” as areas of opportunity in the early development of this new marketplace. Explores scenarios for the future development of “bancassurer” offerings and for electronic commerce as a whole. Draws on some of Hyperion’s recent experience in helping to launch electronic commerce services on the Internet, reengineering of financial institutions and electronic cash, to suggest approaches for organizations wishing to participate in this new “marketspace. ” While businesses can now begin to develop strategies for exploiting cyberspace, argues that existing organizational structures may be inappropriate.
Opposing HDAC4 nuclear fluxes due to phosphorylation by β‐adrenergic activated protein kinase A or by activity or Epac activated CaMKII in skeletal muscle fibres

• Application of either the beta‐adrenergic agonist isoproterenol, dibutyryl cAMP or specific PKA activator N6 benzoyl cAMP caused nuclear influx of wild‐type (wt) HDAC4‐GFP expressed in cultured adult skeletal muscle fibres, but caused no change in nuclear/cytoplasmic distribution of expressed ‘mut’ HDAC4‐GFP mutated (S 265 and 266 to A) at the protein kinase A (PKA) phosphorylation site(s), demonstrating that PKA promotes HDAC4 nuclear influx by phosphorylation of HDAC4 at the PKA sites. • In non‐transfected muscle fibres, myocyte enhancer factor 2 (MEF2)‐driven luc reporter activity was decreased by application of isoproterenol, indicating that endogenous HDAC4 increased in fibre nuclei and suppressed MEF2 transcriptional activity. Levels of phosphorylated (i.e. active) PKA were elevated by exposure to dibutyryl (Db) cAMP. • Fibre repetitive electrical stimulation with 10 Hz trains caused a CaMKII dependent nuclear efflux of wt and mut HDAC4, which was partially decreased by Db cAMP for wt but not for mut HDAC4‐GFP. • The specific activator 8‐CPT of Epac caused efflux of both wt and mut HDAC4‐GFP, which was eliminated by the CaMK inhibitor KN‐93 or by buffering cytosolic Ca2+ using BAPTA‐AM loading, both of which also eliminated a slow elevation of cytosolic Ca2+ during 8‐CPT application. • Using a submaximally effective stimulus frequency of 4 Hz trains of electrical stimulation, Db cAMP increased the rate of nuclear influx of mut HDAC4‐GFP, which cannot be phosphorylated by PKA but can be phosphorylated by CaMKII, which is here activated via the cAMP/Epac pathway. • Immunostain for active PKA or for GTP‐bound RAP1, which is an indicator of Epac activation, showed responses consistent with the functional results above.
Specificity in monosynaptic and disynaptic bulbospinal connections to thoracic motoneurones in the rat

• In the rat, unlike in other species, motoneurones of both the internal intercostal nerve and the external intercostal nerve show a phase of excitation in expiration. • This study investigated the pathways transmitting this excitation from the medulla. • Direct (monosynaptic) excitation was found from individual expiratory neurones in the medulla to internal intercostal nerve motoneurones, but only indirect (disynaptic) excitation was found from the same neurones to the motoneurones of the external intercostal nerve. • This is the first demonstration of two separate pathways from individual long descending fibres specific to two different sets of motoneurones. • This specificity could be useful in studying plasticity or regeneration in thoracic segments in investigations of mechanisms involved in spinal cord injury and repair.
Modulation of synaptic depression of the calyx of Held synapse by GABAB receptors and spontaneous activity

• Spontaneous activity contributes to low synaptic depression of the calyx of Held synapse in vivo. • Application of a reversible blocker in combination with juxtacellular recordings allows a relatively good estimate of local drug concentrations reached during microiontophoresis. • Activation of the GABAB receptor on the young‐adult calyx of Held can reduce short‐term depression, both in vivo and in slices. • The ambient concentration of GABA in the auditory brainstem is low.
Optogenetic identification of an intrinsic cholinergically driven inhibitory oscillator sensitive to cannabinoids and opioids in hippocampal CA1

• Low‐frequency (4–14 Hz, ‘theta’) neuronal oscillations are essential for various animal behaviours, and are strongly influenced by inhibitory neuronal activity, although the interneurons responsible for such activity are not known. • We used optogenetic methods to identify the generators of cholinergically activated, theta‐frequency inhibitory postsynaptic currents (IPSCs) in mouse CA1 hippocampus. • Rhythmic IPSCs are driven by the activation of muscarinic acetylcholine receptors (mAChRs) via mAChR agonist application or ACh release from cholinergic axons. • The output of parvalbumin (PV)‐expressing interneurons was prevented optogenetically or pharmacologically without affecting mAChR‐dependent oscillatory IPSCs. Instead, these IPSCs were blocked by inhibiting interneurons that express glutamic acid decarboxylase 2 (Gad2) and cannabinoid receptors, primarily the cholecystokinin (CCK)‐expressing cells. • Theta‐frequency IPSCs were also inhibited by a μ‐opioid receptor agonist, suggesting that, in addition to being a potential substrate for the generation of behaviourally important rhythms, the same interneurons are a site of convergence of the cannabinoid and opioid neuromodulatory systems.
Synchronous occurrence of oral squamous cell carcinoma and Warthin tumor

Oral squamous cell carcinomas (OSCC) and Warthin tumors are relatively common lesions that are encountered in patients who present with head and neck tumors. However, synchronous occurrence of these two tumors is a rare phenomenon. This report describes a 61-year-old patient with a squamous cell carcinoma of the right side of his buccal mucosa, who received extensive surgery including bilateral neck dissection. Histopathological examination of the neck dissection, however, revealed a Warthin tumor of the right parotid gland. It is important to be aware of such a presentation of Warthin tumor to avoid overtreatment for OSCC.
Supporting knowledge transfer in web-based managed IT support

Purpose – The purpose of this paper is to highlight the importance and complexities of the knowledge transfer process in the provision of effective managed after‐sales IT support, when the web is used for service delivery.Design/methodology/approach – The paper features an interpretive case study of a multi‐national Managed Service Provider (MSP) and a focus group of representatives from five comparable MSPs.Findings – The paper finds that MSPs that use web‐based channels for the provision of after‐sales IT support services need to address a range of important social and organisational issues in order to realise cost and efficiency‐based benefits.Research limitations/implications – The paper provides a four stage processual model of knowledge transfer in the provision of web‐based managed after‐sales IT support services. The barriers and enablers of knowledge transfer at each stage are identified. The paper adopts a MSP perspective and suggests that further research from the customer perspective is requir.
An examination of the critical factors affecting consumer acceptance of online banking: A focus on the dimensions of risk

Purpose – The recent advances in the technology of electronic banking have helped develop new ways of handling banking affairs, especially through online banking. Moreover, the rapid development of the internet has stimulated the banking sector towards encouraging customers to make their transactions online. The purpose of this paper is to introduce an extended technology acceptance model (TAM) model as a tool for examining the factors that have a significant impact on customers' online banking acceptance.Design/methodology/approach – The typical TAM constructs were enhanced with the variables of perceived risk and quality of the internet connection. The proposed conceptual framework of the study (extended TAM), was tested on a sample of Greek internet users. Data were analysed using the “structural equation modelling” technique.Findings – Results provide overall support for the extended TAM model and confirm its robustness in predicting customers' intention of adoption of internet banking. More specifica.
How Well Prepared are Newly Qualified Social Workers for Working with Substance Use Issues? Findings from a National Survey in England

There is limited research in the United Kingdom on how well prepared social workers are for working with substance use issues. This study set out to explore the views of newly qualified social workers on the extent to which their qualifying programme prepared them for practice with people using alcohol or drugs. It also sought to identify their future training needs and identify examples of good practice among qualifying programmes. A self-completion questionnaire was developed and disseminated via email to 2,914 newly qualified social workers in England; 284 questionnaires were returned. Findings suggested that most respondents considered themselves inadequately prepared for working with substance use and misuse issues. They reported having very little input during qualifying education and identified a range of future training needs. Few examples of good practice were identified. In light of these findings, social work academics and employers need to recognise this serious gap in knowledge and act quickly to ensure social workers are able to meet their service users’ needs confidently and competently.
Modulation of stimulus‐specific adaptation by GABAA receptor activation or blockade in the medial geniculate body of the anaesthetized rat

Neurons in the medial geniculate body (MGB), the auditory thalamus, give stronger responses to rare sounds than to repetitive sounds, a phenomenon referred to as stimulus‐specific adaptation (SSA). The present study sought to elucidate how the inhibitory thalamic circuitry acting at GABAA receptors affects the generation and/or modulation of SSA from recordings of single unit responses from MGB. Microiontophoretic application of GABAergic agonists selectively increased SSA indices, whereas application of antagonists selectively reduced SSA values. We found that GABAA‐mediated inhibition did not generate the SSA response but regulated the magnitude of SSA sensitivity in a gain control manner. These findings advance our understanding of the role of inhibition in coding deviance detection in the MGB.
Hypermuscular mice with mutation in the myostatin gene display altered calcium signalling

Hypermuscularity associated with naturally occurring mutations in the myostatin gene as found in Compact mice results in increased muscle mass but reduced specific force. The calcium sensitivity of the contractile apparatus as assessed on chemically skinned skeletal muscle fibres under isometric conditions is not altered in these animals. While the resting calcium concentration remains unaffected, depolarization‐evoked increases in intracellular calcium concentration are suppressed. Spontaneous calcium release events from sarcoplasmic reticulum are also decreased in frequency, amplitude and spatial spread. Our results suggest that mutations in the myostatin gene are accompanied by alterations in excitation contraction coupling, which manifest as a reduction in sarcoplasmic calcium release.
Key challenges in the search for the effective management of knowledge in management consulting firms

Consulting firms cite knowledge management as a core capability for achieving competitive advantage. Consistent with this claim has been their increasing investment in systems that seek to formalize knowledge management and allow firms to leverage the knowledge held within the firm. However, despite some successes, knowledge management remains a major challenge. Investigates this situation, using a framework that distinguishes between input and output challenges. Input challenges relate to the production of a knowledge base that is able to be shared within the firm. Output challenges relate to the capacity for effective utilization of any such knowledge base. Concludes with a discussion of the way in which changes in the pattern of consulting services has implications for the sort of knowledge that various consulting firms wish to codify, the dangers associated with codification and the means by which these can be managed.
Effect of erythropoietin administration on mammal aerobic power

The effects of subcutaneous injections of human erythropoietin (rhEpo) on the circulatory response to submaximal and maximal exercise were studied in healthy male subjects (n=15). Hemoglobin concentration [Hb] increased from 152 g · l−1 to 169 g · l−1 and in parallel maximal aerobic power (Vo2max) increased from 4.52 to 4.88 l · min−1. There were no significant changes in heart rate, ventilation and blood lactate concentration during the exhausting run. Compared with infusion of red blood cells, there was no significant difference in the increase in Vo2max per gram increase in [Hb]. Systolic blood pressure at 200 W increased from before rhEpo treatment to afterwards. It was concluded that slow (rhEpo treatment) and acute (red blood cell reinfusion) increase of [Hb] resulted in similar increase in Vo2max.