Miracle-dz/UniFAR-FTUs huggingface dataset:
Centrosomal Localization of the Psoriasis Candidate Gene Product , CCHCR 1 , Supports a Role in Cytoskeletal Organization Tervaniemi

CCHCR1 (Coiled-Coil a-Helical Rod protein 1), within the major psoriasis susceptibility locus PSORS1, is a plausible candidate gene with the psoriasis associated risk allele CCHCR1*WWCC. Although its expression pattern in psoriatic skin differs from healthy skin and its overexpression influences cell proliferation in transgenic mice, its role as a psoriasis effector gene has remained unsettled. The 59-region of the gene contains a SNP (rs3130453) that controls a 59-extended open reading frame and thus the translation of alternative isoforms. We have now compared the function of two CCHCR1 isoforms: the novel longer isoform 1 and the previously studied isoform 3. In samples of Finnish and Swedish families, the allele generating only isoform 3 shows association with psoriasis (P,10). Both isoforms localize at the centrosome, a cell organelle playing a role in cell division. In stably transfected cells the isoform 3 affects cell proliferation and with the CCHCR1*WWCC allele, also apoptosis. Furthermore, cells overexpressing CCHCR1 show isoformand haplotype-specific influences in the cell size and shape and alterations in the organization and expression of the cytoskeletal proteins actin, vimentin, and cytokeratins. The isoform 1 with the non-risk allele induces the expression of keratin 17, a hallmark for psoriasis; the silencing of CCHCR1 reduces its expression in HEK293 cells. CCHCR1 also regulates EGF-induced STAT3 activation in an isoform-specific manner: the tyrosine phosphorylation of STAT3 is disturbed in isoform 3-transfected cells. The centrosomal localization of CCHCR1 provides a connection to the abnormal cell proliferation and offers a link to possible cellular pathways altered in psoriasis. Citation: Tervaniemi MH, Siitonen HA, Söderhäll C, Minhas G, Vuola J, et al. (2012) Centrosomal Localization of the Psoriasis Candidate Gene Product, CCHCR1, Supports a Role in Cytoskeletal Organization. PLoS ONE 7(11): e49920. doi:10.1371/journal.pone. 0049920 Editor: Giuseppe Novelli, Tor Vergata University of Rome, Italy Received August 6, 2012; Accepted October 15, 2012; Published November 26, 2012 Copyright: 2012 Tervaniemi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: This study was supported by Academy of Finland (grant no. 130360; no. 1255560), Finska Läkaresällskapet, Helsinki University Research Funds, Sigrid Jusélius Foundation, Helsinki University Hospital Research Funds (TYH2009233), Swedish Research Council and Swedish Governmental Agency for Innovation Systems Vinnova. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: The authors have declared that no competing interests exist. * E-mail: juha.kere@ki.se
Merced Proceedings of the Annual Meeting of the Cognitive Science Society Title The Effect of Response Set Size on the Stroop Interference Permalink

Previous research on the effect of response set size on the interference resulting from processing in the Stroop task – a paradigmatic test of executive control – brought equivocal conclusions. In the present paper, we analyze what predictions regarding this effect should be drawn from the most influential computational models of the Stroop as well as from our own new model. Then we test these predictions in an experiment, by manipulating response set size as well as the stimuli/response set sizes proportion, finding both evidence in favor of our model and data which is not explained by any
Efficacy and Safety of Flexible Versus Fixed Dosing Intervals of Insulin Glargine 300 U / mL in People with Type 2

Background: Insulin glargine 300 U/mL (Gla-300) has a more constant and prolonged action profile than insulin glargine 100 U/mL and in clinical studies is associated with similar glycemic control but less hypoglycemia. Whether its effects are altered by variability of injection time was examined in two 3-month substudies. Materials and Methods: Eligible participants completing 6 months of optimized treatment with Gla-300 in EDITION 1 (n = 109) and EDITION 2 (n = 89), having a mean hemoglobin A1c (HbA1c) level of 7.3 % (SD 1.0 %), were randomized (1:1) to groups advised to increase variability of between-injection intervals to 24 – up to 3 h or to maintain fixed 24-h intervals for 3 months. Changes of HbA1c level and other efficacy and safety measures were assessed. Results: In the fixed-dosing group, 64% of participants reported all intervals within the 23–25-h range, compared with 15% of those advised flexible dosing. In the fixedand flexible-dosing groups, 12% and 41%, respectively, of between-injection intervals were outside the 23–25-h range, and 2% and 16%, respectively, were outside the 21–27-h range. Least squares mean between-group difference in HbA1c change from baseline was 0.05 % (95% confidence interval [CI], -0.13 to 0.23); for fasting plasma glucose, 2.7 mg/dL (95% CI, -9.0 to 14.4); and for daily basal insulin dose, 0.00 U/kg (95% CI, -0.02 to 0.03). Frequencies of hypoglycemia and adverse events did not differ between groups. Conclusions: The efficacy and safety of Gla-300 demonstrated in EDITION 1 and EDITION 2 are maintained in substudies when the insulin was injected up to 3 h before or after the usual time of administration.
Merced Proceedings of the Annual Meeting of the Cognitive Science Society Title Different Cognitive Mechanisms Account for Different Types of Procedural Steps Permalink

Device-specific errors occur on steps that do not directly contribute to the main goal; examples are the post-completion error and device-initialisation error. Device-specific steps are more likely to be forgotten than their task-specific counterparts. We hypothesise that this is caused by a lower cognitive salience on device-specific steps, resulting in lower associated activation levels. In addition, associative links between device-specific steps may not be as strong as those between task-specific steps. The first experiment explores the differences in performance and eye movements between deviceand task-specific steps. The second experiment looks more closely at the origin of procedural cues for the different types of steps. It was found that eye-movements and performance differ between the types of steps, indicating that different cognitive processes are at work. No differences were found in where cues come from, so an alternative explanation is discussed.
TRANSFORMATIONAL LEADERSHIP AND DEVELOPMENT OF INTELLECTUAL CAPITAL MANAGEMENT STAGES TOWARDS HOSPITAL PERFORMANCE

Malaysia healthcare industry is facing challenges from a rapidly changing operating environment, including spiralling operating costs and expectations on the quality of healthcare. The government is determined to position Malaysia as a hub for healthcare services for the region. High performance in hospitals is achieved through professionals’ competencies in application of knowledge, technologies and other intangible resources which is also known as Intellectual Capital (IC). A shortage of skilled workforce is always a real challenge for hospital; a high demand for a skilled worker especially in healthcare sector will give a significant impact toward the IC of an organisation. Thus it affects the performance of a hospital in providing a top notch service if the hospital keeps on losing its skilled workers. By acknowledging this reality; the management of the hospital needs to formulate a sound strategic planning of IC which should be executed by a clear, determine, focus and capable leader. Thus, the role and sustainability of both public and private hospitals within this environment, to a large extent depend on the characteristics of the leaders who can manage their IC wisely. It seems that the awareness of the importance of IC has been created in this industry, but how far have these IC elements been measured and managed systematically? Very little empirical research has been done to evaluate the linkages between leadership styles and the management of Intellectual Capital in healthcare industry especially hospital. Therefore, the objective of this paper is to discuss on how transformational leadership styles affect the development of Intellectual Capital Management (ICM) stages that would in turn affect the performance of private and public hospitals. The aim of this paper is to propose a theoretical model that explains the above issues. In addition, more rigorous research methods are needed in order to test and validate the Upper Echelon Theory which is newly introduced for this IC field.
Août 2015 Comportement viscoélastique non linéaire des organes pleins de l ’ abdomen

This paper gathers and compares data coming from previous works [8],[9],[10] on the shear viscoelastic properties of porcine kidney, liver, spleen and pancreas. The linear and nonlinear mechanical behavior of these organs were assessed by performing in succession a harmonic test at small strain and a constant strain rate test up to strain in the order of unity. Based on these data we propose a common nonlinear viscoelastic model using a time-fractional strain-dependent kernel. These four organs behave similarly, showing in particular a weak frequency-dependence of their complex shear modulus and a significant strain-hardening. The kidney is the stiffest and the most elastic organ, the pancreas is the most compliant and the most viscous, the spleen has the most extended linear regime while the liver is most strain-hardening. Mots clefs : Mechanical Properties, Biological Soft Tissues, Nonlinear Viscoelastic Constitutive Law 22 ème Congrès Français de Mécanique Lyon, 24 au 28 Août 2015
1 Capital structure determinants of hospitality sector SMEs

The main objective of this paper is to study the ca pital structure determinants of SMEs in the hospita lity sector and how this can influence their level of in debtedness. Using panel data methodology and considering a sample of 43 Portuguese hotels we stu dy the capital structure determinants between 2004 and 2013. The paper intends to examine the indebted ness level in light of the two main theories – the Trade-off theory and the Pecking Order theory. We c hose the hospitality sector because of its importan ce in the Portuguese economy and because this particul r sector has hardly been studied. In addition to t otal indebtedness, we extend the literature by analyzing the differences between short-term and long-term indebtedness. The results obtained suggest that pro fitability, assets tangibility, firm dimension, tot al liquidity and risk are key factors affecting the ca pit l structure of hospitality sector SMEs, while g rowth, other tax benefits and age were not deemed relevant . These results allow us to conclude that Trade-off and Pecking Order theories should not be considered in isolation to explain the capital structure of hospitality sector SMEs.
BIOSTRATIGRAPHY AND PALEOCEANOGRAPHY OF THE PLIOCENE AT SITES 975 ( MENORCA RISE ) AND 976 ( ALBORAN SEA ) FROM A QUANTITATIVE ANALYSIS OF THE PLANKTONIC FORAMINIFERAL ASSEMBLAGES

The Pliocene assemblages of planktonic foraminifers at Sites 975 and 976 were studied quantitatively to obtain data both on the biostratigraphy and on the paleoceanographic conditions prevailing in the western Mediterranean during the Pliocene. Some significant changes in the composition of the assemblages could be used to complement the biochronology of hemipelagic marine sedimentation in the western Mediterranean. Using modern analog techniques, paleoceanographic conditions were assigned to the Pliocene assemblages. The results suggest that during most of the Pliocene the western Mediterranean was characterized by conditions equivalent to those prevailing today in the western Mediterranean and in the North Atlantic, between the parallels of Cape Finisterre and the Canary Islands, although interspersed with episodes both of subpolar and subtropical conditions. In the latest Pliocene, there were frequent subpolar conditions, presaging the entry of polar fauna that marks the beginning of the Pleistocene.
Effect of Sowing Date and Nitrogen Fertilization Level on Growth and Productivity of Some Durum and Bread Wheat Varieties

Two field experiments were conducted during the winter seasons of 2013/2014 and 2014/2015 at the Agricultural Research Station, Faculty of Agriculture, Alexandria University, Egypt, to study the response of two durum (Sohag 3 and Karim) and two bread (Misr1 and Casino) wheat varieties to three sowing dates (November 1, November 15 and December 1) and two nitrogen fertilization levels (95.2 and 190.4 kg N/ha). The experimental design was a splitsplit plot, with five replications, and the main, sub-and sub-subplots were assigned to sowing dates, nitrogen levels and varieties, respectively. The November 15 sowing date was the most suitable sowing date which gave the highest values for phonological characters and grain yield and its components, whereas, December 1 showed an apparent increase in grain protein content, compared to the two other sowing dates. Increasing N fertilization level from 95.2 to 190.4 kg N/ha significantly increased all phonological traits, grain yield and its components and grain protein content characters. Misr1 variety was superior to the other cultivars in phonological characters and grain yield and its components, except for the number of spikes/m, harvest index and protein content where Sohag 3 showed significantly higher values than the other varieties. The three-factor interaction was insignificant, while, the twofactor interactions, D*N, V*D and V*N were significant for different characters in the two seasons. The best combination of the three factors for grain yield was Misr1, sown on November 15 and fertilized with 190.4 kg N/ha.
Knowledge and Practice of Breast Cancer Screening Among Healthcare Professionals in a Tertiary Health Institution in Nigeria

Breast cancer is the most common cancer afflicting women globally and in Nigeria. Breast cancer screening can reduce morbidity and mortality and improve the survival rate of breast cancer. It is expected that healthcare providers who maintain and develop the society's health, should have a higher level of knowledge, attitudes, and practice in the field of healthy behaviours. This study therefore assessed the knowledge of female healthcare providers/professionals on breast cancer, breast cancer screening services and also their awareness of the availability of these screening services in the tertiary institution where they work. The study employed a cross-sectional design. A self-administered semi-structured questionnaire was administered to healthcare providers of different professional backgrounds to determine their knowledge on breast cancer, screening services and also their awareness of the availability of breast cancer screening services in the hospital where they work. The findings of this study showed that majority of the healthcare providers (75.9%) had a good knowledge of breast cancer screening services, however, only few utilize the available screening services. Although more than half of the participants practice self -breast examination, only 51.7% practice it each month. Only 26.4% of the respondent has undergone clinical breast examination. Furthermore, majority (78.2%) of the respondents were aware of mammography as a screening test, however, only 9.2% of the respondents had ever undergone a mammography before. For health workers to function as effective promoters of breast cancer control through early detection, it is expedient for them to have adequate knowledge as well as appropriate attitude and belief concerning the disease and its early detection. It is therefore recommended that educational intervention be made to increase the knowledge and awareness of healthcare professionals on breast cancer.
Authu.intic Versus Edited Texts

The problem of lack of information regarding the relationship among second language students' language ability, metacognition, and reading materials is examined. The study investigates how reading strategics transfer from the native language to the second language within ar interactive and compensatory processing model frameworX. It examines the similarities and differences in processing within the foreign language (e.g., Spanish) on the basis of text-type (authentic versus simplified). Findings suggest that students process passages in the foreign language differently compared to their processing of the native language. Strategies of successful readers in the foreign language, however, tend to resemble strategies used in the native language. Strategies used to process edited texts are significantly different from those used for processing authentic texts. Successful reading comprehension by text appears to be more a function of either strategies employed or background familiarity, and not language proficiency. Contains 82 references. (Author/LB)
The effects of ultrasound and shockwave treatment on muscle regional oxygen saturation using near-infrared spectroscopy

ABSTRAKTWstęp: Terapeutyczne fale ciśnieniowe są często stosowane w leczeniu różnych schorzeń układu mięśniowo-szkieletowego, niemniej jednak efekt biologiczny ich odziaływania wciąż nie został w pełni poznany. W przedstawionych badaniach oceniono wpływ fal dźwiękowych o różnej sile bodźca stosowanych w terapii falą ultradźwiękową (ultrasound therapy – UST) i pozaustrojową radialną falą uderzeniową (radial extracorporeal shockwave therapy – rESWT) na wysycenie tlenem tkanki mięśniowej i temperaturę powierzchniową w kontekście potencjalnego efektu troficznego przy użyciu spektroskopii bliskiej podczerwieni (near-infrared spectroscopy). Materiały i metody: Badaniem objęto 41 zdrowych ochotników, w tym 27 poddanych UST i 14 rESWT, w wieku 22–48 lat. Pomiar saturacji tkankowej i temperatury powierzchni obszaru mięśnia podgrzebieniowego wykonano 4-krotnie: bezpośrednio przed (T0) i po (T1) oraz 15 (T2) i 30 min po aplikacji bodźca (T3). Saturacje mięśni zmierzono na 2 głębokościach: 20 mm (czujnik 1 – S1) i 12,5 mm (czujnik 2 – S2). Wyniki: Wartość regionalnej perfuzji tkankowej (rSO2 [%]) istotnie zmniejszyła się natychmiast oraz po 15 i 30 min od UST. Wartości początkowe, wynoszące 71,26 ±5,47% (S1) i 88,26 ±2,89% (S2) dla odpowiednich głębokości, znacząco spadły po bodźcowaniu odpowiednio do 68,89 ±5,26% (T2) i 68,93 ±5,12% (T3) na głębokości 20 mm i 86,63 ±5,37% (T1) i 86,52 ±3,38% (T2) na głębokości 12,5 mm.Wnioski: Uzyskane wyniki wskazują, że tylko leczenie za pomocą UST ma znaczący wpływ na zmiany oksymetrii regionalnej, co tłumaczy się ich działaniem przekrwiennym i termicznym w tkankach głębokich, które z kolei indukują dysocjacje tlenu z hemoglobiny do tkanek i efekt troficzny.
職域胃検診におけるH. pylori IgG 抗体測定の有用性について

In 1983, Helicobacter pylori (previously known as Campylobacter pylori) was found in close contact with gastric epithelium in biopsy samples showing active type B or chronic gastritis (6,7,8,9,10). Although the source of H. pylori infection is unknown, reports (3,12,14) have shown quite convincingly that H. pylori infection can be associated with chronic gastritis. A positive correlation has been found between the presence of H. pylori and gastric lesions in some cases of duodenal ulcers (15,16). Complete resolution of gastritis after eradication of the organism has also been reported (17,18).
The Role of Context in Virtual Work Contributors : 1

In this symposium we address the tension between working remotely ‘anytime, anywhere and with anyone’ and the individual embeddedness of the collaborators in a specific local physical, social, cultural, mental and symbolic space. In virtual work, there are two main reasons why the importance of context increases and adds further layers of meaning to context: a) the variety of locations collaborators work from, and b) the dynamic of changing locations while working that is made possible by mobile devices and wireless connections. However, so far the role of context has not been explicitly addressed as a concept relevant to theorizing and researching virtual work. The role of context can be approached from three perspectives: Firstly, we suggest that a reconsideration of conventional views of technology may help us to more effectively study the multiple, emergent, and dynamic socio-material configurations that constitute contemporary organizations and their practices. Secondly, developments in mobile technologies and infrastructures enable increasingly flexible ways of working. Thirdly, we would like to propose Lewin’s idea of ‘life space’ (Lebensraum) as a way of understanding the multiple layers of meaning of ‘context in virtual work’. The four papers and the critical review by the discussant expand our understanding on the role of context by addressing the different layers relevant to context in virtual work: The relevance of a physical place in mobile work, familiarity as a feature of social space in teamwork, the cultural and social space of status cues in communication, and the symbolic space of linguistic markers. AoM Submission 13582 3
Spatio-temporal dynamics of plant invasions : Linking pattern to process 1

Biological invasions are characterized by remarkable spatio-temporal dynamics, with many species having extended their distribution range from within a single region to much of the globe within the last century. The comparative analysis of the spatio-temporal dynamics of over 100 taxa from studies undertaken worldwide provides the basis of a critical assessment of current knowledge. At the scale of single habitats, simple reaction-diffusion models may be accurate enough to predict the spread of new invaders without recourse to complex life history parameterization. Average rates of local spread reported for invasive species in the literature range from 2 m·y-1 to a maximum of 370 m·y-1. Average rates of long-distance dispersal are at least two orders of magnitude greater than estimates of local dispersal, with a maximum of 167 km·y-1. While local-scale studies do pick up dispersal events of several kilometres, study sites are rarely sufficiently large or monitored for long enough to characterize these events accurately. Long-distance dispersal events may occur during periods of negligible population increase and appear to bear little relationship to population size. At regional scales, invasive species rarely move across the landscape as a continuous front and both local and long-distance dispersal determine spatial patterns. At these larger spatial scales, both local and long-distance dispersal require parameterization, and this has been achieved through spatially explicit individual-based simulation models using two or more dispersal functions. It is doubtful whether a single estimate of spread encapsulates the spatio-temporal dynamics of invasive species at this scale. Thus, estimates of spread drawn from successive distribution maps will tend to be biased towards long-distance dispersal events. The frequency and distribution of introduction events play a key role in invasion trajectories, and the stochastic nature of such events may explain why the longer a species has been introduced into a region the greater the likelihood that it becomes invasive. However, cumulative counts of localities or samples only provide one perspective on the invasion process and need to be associated with spatial information to depict spread more realistically. This review highlights that monitoring of invasive species must be approached from a hierarchical perspective with data gathered at more than one spatial scale. Such an approach will improve predictions and integrate landscape attributes into invasion dynamics.