Miracle-dz/UniFAR-FTUs huggingface dataset:
Power Control in UAV-Supported Ultra Dense Networks: Communications, Caching, and Energy Transfer

By means of network densification, ultra dense networks (UDNs) can efficiently broaden the network coverage and enhance the system throughput. In parallel, unmanned aerial vehicle (UAV) communications and networking have attracted increasing attention recently due to their high agility and numerous applications. In this article, we present a vision of UAV-supported UDNs. First, we present four representative scenarios to show the broad applications of UAV-supported UDNs in communications, caching, and energy transfer. Then we highlight the efficient power control in UAV-supported UDNs by discussing the main design considerations and methods in a comprehensive manner. Furthermore, we demonstrate the performance superiority of UAV-supported UDNs via case study simulations, compared to traditional fixed-infrastructure-based networks. In addition, we discuss the dominating technical challenges and open issues ahead.
Effective Factors Increasing the Students’ Interest in Mathematics in the Opinion of Mathematic Teachers of Zahedan

The main objective of this study was to identify factors and conditions that motivated and encouraged students towards the math class and the factors that made this class an attractive and lovely one. To do this end, questionnaires consisting of 15 questions were distributed among 85 math teachers working in schools of Zahedan. Having collected and reviewed these questionnaires, it was shown that doing activity in math class (activity of students while teaching) and previous math teachers' behaviors have had much impact on encouraging the students towards mathematics. Separation of educational classroom of mathematics from the main classroom (which is decorated with crafts created by students themselves with regard to math book including article, wall newspaper, figures and formulas), peers, size and appearance of math book, first grade teachers in each educational level, among whom the Elementary first grade teachers had more importance and impact, were among the most influential and important factors in this regard. Then, school environment, family, conducting research related to mathematics, its application in daily life and other courses and studying the history of mathematics were categorized as important factors that would increase the students’ interest in mathematics. Keywords—Interest, motivation, mathematical learning.
The relationship between economic growth and employment

The article finds that productivity in Belgium has tended to slow down over the past three decades. After controlling for that fundamental tendency, the relationship between persons in employment and economic activity appears generally stable over time throughout the business cycle and is generally unaffected by recessions. In Belgium in particular, in terms of deviation from their respective trends, a 1 % rise in GDP brings a 0.5 % increase in employment. That figure is in line with the European average. The downward trend in productivity is accompanied by a shift to the tertiary sector of the economy. That is also one of the factors behind the decline in average working time. Although the relationship between employment and GDP is very stable throughout the business cycle, the recent financial crisis differs from previous recessions in a general tendency to protect jobs at first, in all twelve economies studied in the article. However, that soon came to an end and the situation returned to normal ; if employment is struggling to pick up, that is essentially because of the weakness of the economic recovery. Finally, it is very clear that firms initially respond to fluctuations in the economy by adjusting the hours worked. In Belgium, the elasticity of those hours to economic activity is about 50 % greater than the elasticity of the number of persons employed in all sectors sensitive to the business cycle.
Epidemiology of Primary Liver Cancer

Liver cancer (LC) ranks fifth in frequency in the world with an estimated number of 437,000 new cases in 1990. In developing countries, incidence rates are two- to three-fold higher than in developed countries. The geographic areas at highest risk are located in Eastern Asia, with age-adjusted incidence rates (AAIRs) ranking from 27.6 to 36.6 per 100,000 in men; Middle Africa, with AAIRs ranking from 20.8 to 38.1 per 100,000 in men; and some countries of Western Africa, with AAIRs ranking from 30 to 48 per 100,000 in men. The geographic areas at lowest LC risk are Northern Europe, Australia, New Zealand, and the Caucasian populations in North and Latin America, with AAIRs below 5.0 per 100,000 in men. Excess of LC incidence among men compared to women is universal, with sex ratios between 1.5 and 3.0. Significant variations in LC incidence among different ethnic groups living in the same geographical area and among migrants of the same ethnic groups living in different areas have been extensively described. The variability of LC incidence rates between countries and within countries, strongly suggests differences in exposure to risk factors. The role of chronic infection with the Hepatitis B and hepatitis C viruses (HBV and HCV) in the etiology of LC is well established. The attributable risk estimates for LC for each of these hepatotropic viruses vary among countries but the combined effects of persistent HBV or HCV infections account for well over 80% of LC cases worldwide. Other documented risk factors such as aflatoxin exposure in diets, cigarette smoking, alcohol consumption, and oral contraceptives may explain the residual variation between and within countries. Interactions between some risk factors have been postulated, and are subject of active research. New laboratory techniques and biological markers such as polymerase chain reaction detection of HBV DNA and HCV RNA, as well as specific mutations related to aflatoxin exposure may help to provide quantitative estimates of the risk related to each these factors.
Climate change in the dance studio: Findings from the UK centres for advanced training

Little is known regarding the stability of motivational climate perceptions, or how changes in climate perceptions affect performers. As a result, dancers’ perceptions of the prevailing climate within both regional centers for talented young people and local dance schools were assessed longitudinally and in relation to dance class anxiety and self-esteem. Dancers (M age 14.41, SD 2.10; 75.7% female) completed standardized questionnaires approximately 6 months apart (Time 1 n 327; Time 2 n 264). Both climates were perceived as more task- than ego-involving, but talent center climates were perceived as more task-involving and less ego-involving than local climates. However, dancers found that talent centers became more ego-involving from the middle to the end of the school year, and this change predicted increases in anxiety. Changes in climate perceptions did not predict changes in self-esteem. Results point to the benefits of climates low in ego-involving features if dancers are to experience less anxiety around performance time.
Nonsense mutation in HLA‐B*40:02 in a case with acquired aplastic anaemia: a possible origin of clonal escape from autoimmune insult

The cause of idiopathic aplastic anaemia (AA) has not been clarified, but some evidence supports the role of T cell-mediated autoimmune destruction of haematopoietic stem/progenitor cells (HSPCs; Young & Maciejewski, 1997). The condition of approximately 70% of patients with idiopathic AA has been observed to improve after immunosuppressive therapy (IST; Bacigalupo et al, 2000; Kojima et al, 2000). In vitro monoclonal or oligoclonal expansion of CD8 T-cells has been noted in patients with idiopathic AA (Risitano et al, 2004). However, the target antigens of T cells have not been clearly identified. Katagiri et al (2011) reported that a considerable proportion of Japanese patients with idiopathic AA acquired copy number-neutral loss of heterozygosity of the 6p arms (6pLOH), leading to loss of one human leucocyte antigen (HLA) haplotype. Moreover, the missing haplotype was concentrated in particular alleles: HLA-A*02:01, HLAA*02:06, HLA-A*31:01 and HLA-B*40:02. Furthermore, Japanese patients with idiopathic AA typically inherited only those four HLA alleles (Katagiri et al, 2011). These findings suggest that these HLA alleles are the target antigens of T cells in the pathogenesis of idiopathic AA and 6pLOH is the mechanism by which HSPCs escape from autoreactive cytotoxic T-lymphocytes (CTL). In this study, we report a patient with idiopathic AA who carried a nonsense mutation in an HLA allele. Tracing the case history with fluctuations in her HLA typing illustrated how HSPCs escape from autoimmune insult. A 2-year-old girl was diagnosed with severe acquired AA. Neither chromosomal abnormalities nor morphological dysplasia was observed in her bone marrow cells. Serological HLA typing was performed using the Terasaki–NIH Standard method, revealing that her phenotypes (A24/-, B55/B61, DR8/DR9) completely matched those of her father. She received immunosuppressive therapy for 20 months, leading to partial remission, but she relapsed with thrombocytopenia 7 months after discontinuing IST. Although she was retreated with IST, regular blood transfusions had been required since the age of 5 years. Therefore, stem cell transplantation was scheduled at the age of 7 years. Confirmation of her HLA type by high-resolution sequencing-based typing of a peripheral blood sample, revealed a nonsense mutation (CAG to TAG) at codon 54 in exon 2 of either HLA-B*40:02 or HLA-B*55:02 (Fig 1A). In contrast, no mutation in HLA-B alleles was found in either of her parents. To resolve the discrepancy, we re-examined the serological HLA typing by the same method. Analysis of her blood sample demonstrated that the HLA-B61 antigen, corresponding to
A Clinical Study on Maternal and Fetal Outcome in Multiple Pregnancies in Women Attending Government Maternity Hospital , Tirupathi .

DR. C.MANJU YADAV 1, DR.T. BHARATHI 2, DR.P.A.CHANDRASEKHARAN 3, DR.C. BRAMARAMBA 4 1(ASSISTANT PROFESSOR, DEPT OF OBG, SRIPADMAVATHI MEDICAL COLLEGE FOR WOMEN, SVIMS, ANDHRA PRADESH, INDIA.) 2 (PROFESSOR AND SUPERINTENDENT, DEPT OF OBG, ACSR MEDICAL COLLEGE, NELLORE, ANDHRA PRADESH, INDIA) 3(PROFESSOR, DEPT OF OBG, GMH, SRIVENKATESHWARA MEDICAL COLLEGE, ANDHRA PRADESH, INDIA) 4(ASSISTANT PROFESSOR, DEPT OF OBG, SRIVENKATESHWARA MEDICAL COLLEGE, ANDHRA PRADESH, INDIA) Abstract: Objective: To study the prevalence, etiological factors, maternal and foetal outcome in multiple gestation Methods: All women with multiple gestation admitted at Government Maternity Hospital, Tirupathi from January 2012 to August 2013 were studied. Results: Incidence of multiple pregnancies in present study was 1.09%. Of which 235 are twins, 6 triplets and 1 quadruplet. 60.3% of multiple pregnancies is found in age group of 21-25, 41.3% incidence is noted in primigravidas.7. 36% have family history of multiple pregnancy ,5.3% in maternal side and 2.06% in paternal side.9. 09% taken ovulation induction drugs, 3.3% had past history of twin pregnancy. Maternal complications were preterm labour 43.3%, anaemia 26.03%, hypertensive disorders 19.4%, and severe postpartum haemorrhage 2.4% were seen. Vertex-vertex was the most common presentation noted with 63.6% followed by breech-breech 11.5%. Incidence of caesarean section accounts for 28.5% and exclusively for 2nd twin is 4% and the most common indication was non vertex presentation of 1sttwin.Dichorionic placentation accounts for 65.7% monochorionic in 31.3% and trichorionic in 2.4% of cases. Perinatal deaths are highest when birth weight is < 1.5kg, Intertwin delivery interval, gestational age and monochorioncity had a significant association with perinatal mortality. Perinatal morbidity is twin 1 is 16.7% and twin 2 is 18.5%. No maternal deaths noted. Conclusion: Multiple pregnancies are associated with increasing risk for mother and baby. Gestational age, birth weight and intertwin delivery interval are important determinants of neonatal outcome. Earlier determination of chorionicity is useful in assessing the prognosis of multifetal gestation. Outcomes can be improved with appropriate interventions.
Imipenem resistance in Pseudomonas aeruginosa resulting from diminished expression of an outer membrane protein

The mechanism of Pseudomonas aeruginosa resistance to imipenem in five imipenem-susceptible clinical isolates and in their resistant counterparts was investigated. The frequency for selecting imipenem-resistant variants ranged from 2.7 X 10(-5) to 2.1 X 10(-8) and was comparable to those for other beta-lactams. Cross-resistance between imipenem and other beta-lactam compounds was not observed. In all imipenem-resistant variants, induction of chromosomal beta-lactamase by imipenem was markedly diminished compared with that in the susceptible parent strain. This was not the case for other inducers such as ampicillin or cefoxitin, suggesting an impaired uptake of imipenem as an explanation for resistance. Analysis of the outer membrane proteins revealed a marked decrease of either a 46- or a 45-kilodalton protein. The lipopolysaccharide of the outer membrane in the imipenem-resistant variants was not altered.
Functional Analyses of Patient-derived IgG Monoclonal Anticardiolipin Antibodies Using In Vivo Thrombosis and In Vivo Microcirculation Models

Summary Antiphospholipid antibodies (aPL) have been associated with thrombosis and pregnancy losses in patients diagnosed with antiphospholipid syndrome (APS) and enhance thrombus formation in vivo in mice, but the mechanism of thrombosis by aPL is not completely understood. It has been proposed that aPL may affect endothelial cell (EC) function and/or induce their activation, transforming their anticoagulant surface into procoagulant, thus predisposing to thrombosis. It has been proposed that aPL may affect EC cell function and/or induce their activation, transforming their anticoagulant surface into procoagulant, thus predisposing to thrombosis. This study proposes to test the hypotheses that some IgG anticardiolipins (IgG aCL) with thrombogenic properties in mice, exert their effects through activation of endothelium. We studied seven patient-derived monoclonal aCL for their thrombogenic properties in an in vivo pinch-induced thrombosis model, and their functional activities in activating EC by analyzing in vivo leukocyte adhesion to endothelium in microcirculation in venules in exposed murine cremaster muscle and in vitro adhesion molecule expression in cultured EC. The binding of the monoclonal aCL to EC was also tested. In addition to the previous identified thrombogenic IS2, four of the five new more IgG monoclonal aCL (from two patients) were found to be thrombogenic. Of these five thrombogenic aCL, three caused more in vivo leukocyte adhesion to EC in microcirculation, as compared to that induced by the H2 control human monoclonal IgG, and enhanced expression of adhesion molecules (particularly VCAM-1) on cultured EC. These data show that about 2/3 patientderived IgG monoclonal aCL are thrombogenic and suggest that some thrombogenic IgG aCL exert their effects through activating EC. Abbreviations: aCL, anticardiolipin antibodies; aPL, antiphospholipid antibodies; APS, antiphospholipid syndrome; CL, cardiolipin; dRVVT, dilute Russell’s viper venom time; EC, endothelial cells; ELISA, enzyme-linked immunosorbent assay; GP, glycoprotein; h, hour; HUVEC, human umbilicalvein endothelial cells; ICAM, intercellular adhesion molecule; KCT, kaolin clotting time; LA, lupus anticoagulant; PBS, phosphate-buffered saline; PL, phospholipid; sq, square; TBS, Tris-buffered saline; VCAM, vascular cell adhesion molecule; PMBC, peripheral mononuclear blood cells
Zerumbone inhibits growth of hormone refractory prostate cancer cells by inhibiting JAK2/STAT3 pathway and increases paclitaxel sensitivity

Zerumbone, a phytochemical isolated from Zingiber zerumbet has been shown previously to exhibit antineoplastic activity. But, the effect of zerumbone in prostate cancer has not been evaluated. Prostate cancer is frequently associated with elevated levels of interleukin-6 (IL-6), which exerts its oncogenic effects through activation of Janus kinase 2 (JAK2) followed by activation of the transcription factor STAT3 (signal transducer and activator of transcription 3). Here, we investigated whether the anticancer effects of zerumbone are mediated through inhibition of the JAK2/STAT3 signaling pathway and whether zerumbone can increase the paclitaxel (PTX) sensitivity of prostate cancer cells. Zerumbone exerted significant cytotoxicity of DU145 versus PC3 prostate cancer cells through cell cycle arrest at G0/G1 phase followed by apoptosis. Zerumbone selectively inhibited JAK2 in both DU145 and PC3 cells. However, the biological axis of IL-6/JAK2/STAT3 was inhibited only in DU145 cells as no STAT3 phosphorylation was detected in PC3 cells even after IL-6 stimulation. Other signaling pathways in DU145 cells remained unaffected. The expression of prostate cancer-associated genes, including cyclin D1, IL-6, COX2, and ETV1, was blocked. Zerumbone also synergistically increased the sensitivity to PTX. Further preclinical study might reveal the potential use of zerumbone as a chemotherapeutic agent for hormone refractory prostate cancer where IL-6/JAK2/STAT3 signaling is aberrantly active and may be combined with PTX.
[Influence of obstructive jaundice on postoperative complications and mortality after pancreaticoduodenectomy: analysis of the 25-year single-center data].

OBJECTIVE To study the influence of the depth of jaundice, the duration of jaundice and preoperative biliary drainage (PBD) on postoperative complications and mortality after pancreaticoduodenectomy (PD). METHODS A retrospective review was performed of the medical records of 1025 patients who underwent PD between June 1986 and December 2010. The patients comprised 659 men and 366 women, ranging from 4 to 81 years old with a mean age of (54 ± 12) years. The indications for PD were malignant disease in 869 patients (84.78%) and benign or borderline tumors in 156 patients (15.22%). The operative procedures performed were pylorus-preserving modification in 279 patients and conventional PD, i.e. Whipple's operation in 746 patients. Complications after PD were compared among the different groups which was classified according to the depth of obstructive jaundice, the duration of obstructive jaundice and whether undergoing preoperative biliary drain or not, and the analysis was made by variance analysis and χ(2) test respectively. RESULTS The depth of jaundice did not significantly affect the incidence of complications after PD except for the hemorrhage complication (χ(2) = 11.06, P = 0.03). The duration of jaundice had no much influence on the postoperative complications and mortality. PBD could not reduce the postoperative complications and mortality, however, it would increase the incidence of postoperative incision infection (χ(2) = 9.84, P = 0.01). No significant relationship was observed between the duration of PBD and the postoperative complications and mortality. CONCLUSIONS Either the depth or duration of obstructive jaundice has no relationship with the postoperative complications and mortality after PD but the postoperative hemorrhage. Patients undergoing PD can not be benefited from PBD. Consequently, PBD should not be performed routinely, but it can be used in some serious patients with severe depth of jaundice who can not received surgery at once.
Linking automated data analysis and visualization with applications in developmental biology and high-energy physics

Knowledge discovery from large and complex collections of today’s scientific datasets is a challenging task. With the ability to measure and simulate more processes at increasingly finer spatial and temporal scales, the increasing number of data dimensions and data objects is presenting tremendous challenges for data analysis and effective data exploration methods and tools. Researchers are overwhelmed with data and standard tools are often insufficient to enable effective data analysis and knowledge discovery. The main objective of this thesis is to provide important new capabilities to accelerate scientific knowledge discovery form large, complex, and multivariate scientific data. The research covered in this thesis addresses these scientific challenges using a combination of scientific visualization, information visualization, automated data analysis, and other enabling technologies, such as efficient data management. The effectiveness of the proposed analysis methods is demonstrated via applications in two distinct scientific research fields, namely developmental biology and high-energy physics. Advances in microscopy, image analysis, and embryo registration enable for the first time measurement of gene expression at cellular resolution for entire organisms. Analysis of highdimensional spatial gene expression datasets is a challenging task. By integrating data clustering and visualization, analysis of complex, time-varying, spatial gene expression patterns and their formation becomes possible. The analysis framework MATLAB and the visualization have been integrated, making advanced analysis tools accessible to biologist and enabling bioinformatic researchers to directly integrate their analysis with the visualization. Laser wakefield particle accelerators (LWFAs) promise to be a new compact source of highenergy particles and radiation, with wide applications ranging from medicine to physics. To gain insight into the complex physical processes of particle acceleration, physicists model LWFAs computationally. The datasets produced by LWFA simulations are (i) extremely large, (ii) of varying spatial and temporal resolution, (iii) heterogeneous, and (iv) high-dimensional, making analysis and knowledge discovery from complex LWFA simulation data a challenging task. To address these challenges this thesis describes the integration of the visualization system VisIt and the state-of-the-art index/query system FastBit, enabling interactive visual exploration of extremely large three-dimensional particle datasets. Researchers are especially interested in beams of high-energy particles formed during the course of a simulation. This thesis describes novel methods for automatic detection and analysis of particle beams enabling a more accurate and efficient data analysis process. By integrating these automated analysis methods with visualization, this research enables more accurate, efficient, and effective analysis of LWFA simulation data than previously possible.
M-CSF Induces Vascular Endothelial Growth Factor Production and Angiogenic Activity From Human Monocytes 1

The impact of the immune response in malignancy is poorly understood. While immune cells can destroy transformed cells, the targeting and accumulation of monocytes and macrophages at tumor sites may promote tumor metastases. The growth factor M-CSF is important in promoting monocyte survival. Since M-CSF−/− mice are protected against tumor metastases, we hypothesized that M-CSF induced monocytes to produce angiogenic factors that facilitate metastases. In this study we demonstrate that recombinant human M-CSF induces freshly isolated normal human monocytes to produce and release the growth factor vascular endothelial growth factor (VEGF) in a dose-dependent manner, which peaked at 5 days in culture. VEGF released by these monocytes is biologically active, as cell-free supernatants from these M-CSF-stimulated monocytes induced tube formation in HUVEC. Network formation by these HUVECs after treatment with supernatants from monocytes stimulated with M-CSF were inhibited by anti-VEGF, but not by the isogenic control, Abs. Collectively, these data support an important role for M-CSF and monocytes in VEGF production and angiogenesis.