Miracle-dz/UniFAR-FTUs huggingface dataset:
Sources of competitive advantage for Malaysian micro-enterprises

Purpose Entrepreneurial activities are embedded within the networks of social relationships, which facilitate the flow of crucial information and resources. This study aims to examine the effect of social capital (i.e. structural, cognitive and relational), entrepreneurial competencies (i.e. commitment, conceptual and organizing) and micro-enterprise innovativeness (i.e. innovativeness and absorptive capacity) on the competitive advantages of the micro-enterprises owned and managed by women micro-entrepreneurs in Peninsular Malaysia. Design/methodology/approach This study used a cross-sectional design and collected quantitative data from 417 women micro-entrepreneurs from six selected states in Peninsular Malaysia through structured interview. For data analysis, this study adopted variance-based structural equation modeling, i.e. PLS-SEM. Findings The findings of this study revealed a significant positive effect of social capital on entrepreneurial competencies, innovativeness and competitive advantage. The findings also revealed a significant positive effect of entrepreneurial competencies on innovativeness and competitive advantage. Originality/value The government and other development agencies working toward enterprise development in Malaysia should therefore focus on designing a platform for women micro-entrepreneurs to promote the development of structural and relational social capital, which foster the flow of crucial information and resources necessary for suitable micro-enterprise performance.
Lipopolysaccharide binds to and activates A1 adenosine receptors on human pulmonary artery endothelial cells

Previously,it was reported that A 1 adenosine receptor antagonists prevent endotoxin-inducedacute lung injury and pulmonary arterial endothelial cell damage. In competition radioligand binding experiments in membranes prepared from human pulmonary artery endothelial cells (PAECs), lipopolysaccharides (LPSs) of Escherichia coli, Salmonella typhimurium, Klebsiella pneumoniae, and Pseudomonas aeruginosa displaced the binding of a selective A adenosine receptor antagonist [125I]-BWA844U (IC 50 values: 195 ng/ml, 290 ng/ml, 602 ng/ml, and 6931 ng/ml, respectively)in a dose-dependent, competitive manner. There was no displacement of this radioligand by enterotoxin (≤ 10 μg/ml), diphosphoryl lipid A (≤ 10μg/ml), and glycolipids, monosialoganglioside(≤ 1μg/ml), lactocerebroside (≤ 100μg/ml), or NBD galactocerebroside (≤ 100 μg/ml). Based on calculated IC values, LPS (E. coli, IC50 111 ng/ml) 50 6 displaced the selective A1 adenosine receptor agonist, [3H]-2-chloro, N -cyclopentyladenosine (CCPA) in human PAECs with a potency profile, CCPA > LPS > 2-phenylaminoadenosine (CV 1808), a selective A2 adenosine receptor agonist. The potency profile for displacement of the selective A μ 2a adenosine receptor agonist [ 3H]-CGS 21680 was CV 1808 > CCPA. LPS (E. coli 0.1 pg/ml—10 g/ml) did not displace [3H]-CGS 21680 binding. In human PAECs, IL-6 and TXA2 release induced by LPS (0—1 μg/ml) or CCPA (0—1 μM) at high doses was significantly reduced by the selective A1 adenosine receptor antagonist, 8-cyclopentyl-1,3-dipropylxanthine(DPCPX; 1 μM). These data suggest that LPS binds to and activates A1 adenosine receptors on human PAECs to induce the release of IL-6 and TXA 2. Activation of A1 adenosine receptors on human PAECs by LPS, may contribute to the pathophysiology of acute lung injury associated with Gram-negative septicemia and endotoxemia.
SUDIKAH AKUNTAN MENGUNGKAP AIB KECURANGAN

Abstrak: Sudikah Akuntan Mengungkap Aib Kecurangan? Penelitian ini bertujuan untuk menguji hubungan kausalitas antara model pahala dan jalur pelaporan serta interaksi antara kedua faktor tersebut dengan niat mengungkapkan aib kecurangan. Metode penelitian yang digunakan adalah eksperimen antarsubjek faktorial 2x2. Penelitian ini menunjukkan bahwa akuntan sudi mengungkap aib kecurangan karena adanya jalur pelaporan tak berindentitas serta model pahala berupa perlindungan. Jaminan keamanan bagi pelapor menjadi faktor utama bagi mereka untuk berani menyampaikan informasi mengenai adanya kecurangan kepada pimpinan organisasi. Pada sisi lainnya, sistem pengungkapan aib perlu mempertimbangkan mekanisme yang memberi perlindungan bagi para pelapor. Abstract: Will the Accountant Whistle the Fraud? The research aims to examine the causality between the reward model, the reporting channel and the interaction between that factors to the whistleblowing intention of fraudulent. This research uses experiment between 2x2 factorial subject. This study shows that the accountant will reveal the cheating inclination due to the existence of non-indexing reporting path and the model of reward in the form of protection. Security guarantees for complainants are the key factor for them to dare to disclose information about fraud to the organization leader. On the other hand, disgrace disclosure systems need to consider mechanisms that provide protection to reporters.
Nonverbal communication in socially assistive human-robot interaction

Socially assistive robots provide assistance to human users through interactions that are inherently social. This category includes robot tutors that provide students with personalized one-on-one lessons (Ramachandran, Litoiu, & Scassellati, 2016), robot therapy assistants that help mediate social interactions between children with ASD and adult therapists (Scassellati, Admoni, & Matarić, 2012), and robot coaches that motivate children to make healthy eating choices (Short et al., 2014).
Prophylactic Phenylephrine Infusion for Preventing Hypotension During Spinal Anesthesia for Cesarean Delivery

In a randomized, double-blinded, controlled trial, we investigated the prophylactic infusion of IV phenylephrine for the prevention of hypotension during spinal anesthesia for cesarean delivery. Immediately after intrathecal injection, phenylephrine was infused at 100 &mgr;g/min (n = 26) for 3 min. From that point until delivery, phenylephrine was infused at 100 &mgr;g/min whenever systolic arterial blood pressure (SAP), measured each minute, was less than baseline. A control group (n = 24) received IV bolus phenylephrine 100 &mgr;g after each measurement of SAP <80% of baseline. Phenylephrine infusion decreased the incidence (6 [23%] of 26 versus 21 [88%] of 24; P < 0.0001), frequency, and magnitude (median minimum SAP, 106 mm Hg; interquartile range, 95–111 mm Hg; versus median, 80 mm Hg; range, 73–93 mm Hg; P < 0.0001) of hypotension compared with control. Heart rate was significantly slower over time in the infusion group compared with the control group (P < 0.0001). Despite a large total dose of phenylephrine administered to the infusion group compared with the control group (median, 1260 &mgr;g; interquartile range, 1010–1640 &mgr;g; versus median, 450 &mgr;g; interquartile range, 300–750 &mgr;g; P < 0.0001), umbilical cord blood gases and Apgar scores were similar. One patient in each group had umbilical arterial pH <7.2. Prophylactic phenylephrine infusion is a simple, safe, and effective method of maintaining arterial blood pressure during spinal anesthesia for cesarean delivery.
Control of Synthesis and Secretion of the Bacillus subtilis Protein YqxM

ABSTRACT yqxM is a Bacillus subtilis gene of unknown function residing in an operon with sipW, which encodes a signal peptidase, and tasA, which encodes an antibiotic protein secreted in a sipW-dependent manner. YqxM was undetectable during growth in a variety of rich media, including Luria-Bertani (LB) medium, or in minimal media or under heat shock or ethanol stress conditions but was synthesized and secreted during growth in LB medium supplemented with 1.2 M NaCl. Consistent with the possible involvement of sipW in YqxM secretion, inactivation of sipW prevented YqxM secretion. YqxM was produced and secreted in a sipW-dependent manner during growth in LB medium when the sequences upstream of yqxMwere replaced with those of the inducible Pspacpromoter. Coexpression of yqxM and sipW inEscherichia coli resulted in a decrease in the apparent molecular mass of YqxM, consistent with the removal of a signal peptide. These experiments suggest that YqxM production is induced by a high concentration of salt and that YqxM is secreted under the control of SipW. We hypothesize that during most conditions of growth, YqxM is present at very low levels or is not synthesized at all and that this low level or absence is due, at least in part, to posttranscriptional repression.
Towards Facility Management Participation in Design: A UCSF Case Study

The discipline of Facility Management (FM) emerged in the 1970s triggered by the concomitance of (1) increasing complexity in the workplace and (2) understanding of an interdependence between users’ behaviors and building design. Despite the existence of FM, a number of buildings today still fail to deliver value during the occupation phase. Although various causes contribute to such failures, this paper focuses on the lack of strategic involvement of Facilities Managers (FMs) in design. It uses the University of California, San Francisco (UCSF) as a case study to describe how an organization has-in the course of its Lean journey-learned the importance, not only of considering FM requirements during design, but more importantly of actively engaging FMs early in the design process. Benefits experienced by UCSF are multiple. One is that FMs understand, perhaps better than designers, the complexity of the programs housed by UCSF buildings and the constraints this complexity imposes on the design requirements. This helps FMs advise on trade-offs between their preferences for simple (e.g., easy-to-maintain) systems and the programs’ needs for complex systems.
HBGG: a Hierarchical Bayesian Geographical Model for Group Recommendation

Location-based social networks such as Foursquare and Plancast have gained increasing popularity. On those sites, users can organize and participate in group activities; hence, recommending venues to a group is of practical importance. In this paper, we study the problem of recommending venues to groups of users and propose a Hierarchical Bayesian Model (HBGG) for this purpose. First, a generative group geographical topic model (GG) which exploits group membership, group mobility regions and group preferences is proposed. And we integrate social structure into one-class collaborative ﬁltering as social-based collaborative ﬁltering (SOCF) to leverage social wisdom. Through the shared latent group features, HBGG connects the group geographical model with SOCF framework for group recommendation. Experimental results on two real datasets show that our methods outperforms the state-of-the-art group recommenders, especially on cold-start user groups.
Coronin 3 and its role in murine brain morphogenesis

Coronins belong to the fundamental WD40‐repeat proteins. They are mainly found at the submembraneous area, they bind F‐actin in vitro, and most of the seven mammalian coronins have unclear roles. Coronin 3 is abundantly expressed in the adult CNS. All murine brain areas express coronin 3 during embryogenesis and the first postnatal stages. Expression in grey matter decreases postnatally, except for hippocampal pyramidal and dentate gyrus neurons, and cerebellar Purkinje cells, while levels in white matter increase in the course of myelination. Consistently, coronin 3 is abundant in differentiating neuro‐2a and PC‐12 cells and in primary oligodendrocytes. Treatment with PKC activator PMA reduced coronin 3 protein levels. To address its functions, neuro‐2a and PC‐12 cells were transfected with GFP‐tagged coronin 3 versions. Full‐length coronin 3 among other areas localized to outgrowing neurites, whereas truncated proteins efficiently suppressed neurite formation. Our results favour a role for coronin 3 in neuron morphogenesis and possibly migration.
Membrane-active peptides

These parameters, which can be determined separately using other techniques along with estimates of the two-dimensional density of the membrane components, provide a prediction of the sensor performance. T h e steps in the detection mechanism are shown in Figure 5. Experimental responses are shown in Figure 6. Discussion Sensitivity Sensitivity is dependent on the antibody 'on rates' and affinity. For an antibody with lo5 M-'s -' 'on rate' and an affinity > 1 nM-', detection to sub-picomolar levels is possible in < 5 min. Stability and variability T h e stability of the tethered membrane has been enhanced by replacing ester with ether linkers. A test of the sealed membrane was successfully extended beyond 3 months when fully hydrated. It has also been shown that the sensing function returns on re-hydrating a fully assembled sensor. Long-term storage will be of dried sensors. Depending on the concentration range, coefficients of variation for the sensor performance are in the range 6-1 5 yo. Chip arrays A major advantage of this approach is the potential for miniaturization. A silicon chip array is under development. An optical technique permits specific receptors to be tethered to chosen sites within the array. Optical patterning T h e patterning of the electrode arrays is by optical masks that permit selective deprotection of biotin sites attached to either the membrane lipid or the ion channels in the membrane.
Reye's syndrome: a clinical review.

Reye's syndrome is a virus-associated biphasic disease that causes acute encephalopathy in infants and children. Epidemiologic and experimental data support the hypothesis that it is a multifactorial disease of modern civilization. Just as young patients seem to be recovering uneventfully from the first phase of the illness, usually a nonspecific viral-like illness such as a respiratory tract infection or gastroenteritis, the second phase, encephalopathy, starts unexpectedly, with vomiting and sensorial changes. Identifying the syndrome early ;in the second phase and referring the child to a specialized centre with the experience, staff and facilities to manage this phase has improved the numbers and neurologic condition of survivors, though the overall mortality is still about 20%. Therapy is primarily directed at facilitating adequate cerebral perfusion pressure.
A New Tracking System for Three Magnetic Objectives

We have implemented a new noninvasive multiobjective tracking system, which can be used for localization of an endoscope and monitoring of heart valve prostheses and gastrointestinal transit of solid oral dosage forms or nutrients. The marker is modeled as a magnetic dipole, and the magnetic field at some point is regarded as summation of those from three dipoles. By minimizing the squared errors of magnetic field values between measurements and calculation using a hybrid of the particle swarm optimization (PSO) algorithm and the clone algorithm, an iterative result can be obtained, which is taken as the initial guess of the Levenberg-Marquardt (L-M) optimization method, and the first point can be determined. Subsequently, the previous computed point is used as the next initial guess of L-M algorithm, and the successive points are calculated. The tracking results demonstrate that the average position error for three objectives is 3.7 mm and the average orientation error is 1.8 when the objectives move randomly in the space surrounded by the sensor array.
Development of Marine and Coastal Tourism Based on Blue Economy

Marine and coastal tourism as one of the largest segments of the maritime economy sector, as well as the largest component of the tourism industry, often leads to controversy over environmental impact and compatibility with other human activities. The application of economic and tourism concepts that are oriented towards environmental conservation and natural resources is one option to overcome the problem. The Blue Economy concept offers an economic concept based on ecosystem principles, where the development will not only generate economic growth but also ensure ecological and social sustainability. In addition, the concept of ecotourism also offers a tourism activity that prioritizes aspects of nature conservation and improving the welfare of the community
Trends in Mediation Analysis in Nursing Research: Improving Current Practice

The purpose of this study was to describe common approaches used by nursing researchers to test mediation models and evaluate them within the context of current methodological advances. MEDLINE was used to locate studies testing a mediation model and published from 2004 to 2015 in nursing journals. Design (experimental/correlation, cross-sectional/longitudinal, model complexity) and analysis (method, inclusion of test of mediated effect, violations/discussion of assumptions, sample size/power) characteristics were coded for 456 studies. General trends were identified using descriptive statistics. Consistent with findings of reviews in other disciplines, evidence was found that nursing researchers may not be aware of the strong assumptions and serious limitations of their analyses. Suggestions for strengthening the rigor of such studies and an overview of current methods for testing more complex models, including longitudinal mediation processes, are presented.
Evaluation of the Modified Medical Research Council Dyspnea Scale for Predicting Hospitalization and Exacerbation in Japanese Patients with Chronic Obstructive Pulmonary Disease.

OBJECTIVE The modified Medical Research Council (mMRC) scale is recommended for conducting assessments of dyspnea and disability and functions as an indicator of exacerbation. The aim of this study was to investigate whether the mMRC scale can be used to predict hospitalization and exacerbation in Japanese patients with chronic obstructive pulmonary disease (COPD). METHODS In a previous 52-week prospective study, 123 patients with COPD were classified into five groups (grades 0 to 4) according to the mMRC scale and four groups (stages I to IV) according to the spirometric Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification. The frequency and period until the first event of hospitalization and exacerbation were compared among the groups. RESULTS The population of patients who experienced hospitalization and exacerbation during the 52-week study period, with an mMRC scale grade of 4, 3, 2, 1 and 0 was 50.0 and 100, 55.6 and 88.9, 21.1 and 73.7, 2.6 and 48.7, and 4.0 and 22.0%, respectively. A multivariate analysis adjusted for the GOLD stage and age showed that the patients with an mMRC scale grade of ≥3 had higher frequencies of hospitalization and exacerbation than those with lower grades. Meanwhile, the patients with an mMRC scale grade of ≥2 showed a significantly earlier time until the first exacerbation, but not hospitalization, in comparison with those with grade 0. CONCLUSION The present results indicate that, among Japanese patients with COPD, those with an mMRC scale grade of ≥3 have a significantly poorer prognosis and that the mMRC scale can be used to predict hospitalization and exacerbation.
A neuroendocrinological perspective on human hair follicle pigmentation

The role of neurohormones and neuropeptides in human hair follicle (HF) pigmentation extends far beyond the control of melanin synthesis by α‐MSH and ACTH and includes melanoblast differentiation, reactive oxygen species scavenging, maintenance of HF immune privilege, and remodeling of the HF pigmentary unit (HFPU). It is now clear that human HFs are not only a target of multiple neuromediators, but also are a major non‐classical production site for neurohormones such as CRH, proopiomelanocortin, ACTH, α‐MSH, ß‐endorphin, TRH, and melatonin. Moreover, human HFs have established a functional peripheral equivalent of the hypothalamic–pituitary–adrenal axis. By charting the author’s own meanderings through the jungle of hair pigmentation research, the current perspectives essay utilizes four clinical observations – hair repigmentation, canities, poliosis, and ‘overnight greying’– as points of entry into the enigmas and challenges of . pigmentary HF neuroendocrinology. After synthesizing key principles and defining major open questions in the field, selected research avenues are delineated that appear clinically most promising. In this context, novel neuroendocrinological strategies to retard or reverse greying and to reduce damage to the HFPU are discussed.
Activity of liposomal amphotericin B against experimental cutaneous leishmaniasis

The polyene antibiotic amphotericin B is currently a second-line treatment for visceral leishmaniasis (VL) and mucocutaneous leishmaniasis. Lipid-amphotericin B formulations with lower toxicity than the parent drug that were developed for the treatment of systemic mycoses have proved to be an effective treatment for VL, especially AmBisome, a small unilamellar negatively charged liposome. In vitro, free amphotericin B was three to six times more active than the liposomal formulation AmBisome against both Leishmania major promastigotes in culture and amastigotes in murine macrophages. In a BALB/c L. major model of cutaneous infection, liposomal amphotericin B administered once a day on six alternate days by the intravenous route produced a dose-response effect between 6.25 and 50 mg/kg. Liposomal amphotericin B administered subcutaneously close to a lesion had no significant activity. Free drug was ineffective at nontoxic doses. The results suggest that liposomal amphotericin B may be useful in the treatment of cutaneous leishmaniasis.
Distinguishing Heavy-Metal Stress Levels in Rice Using Synthetic Spectral Index Responses to Physiological Function Variations

Accurately assessing the heavy-metal contamination in crops is crucial to food security. This study provides a method to distinguish heavy-metal stress levels in rice using the variations of two physiological functions as discrimination indices, which are obtained by assimilation of remotely sensed data with a crop growth model. Two stress indices, which correspond to daily total CO2 assimilation and dry-matter conversion coefficient were incorporated into the World Food Study (WOFOST) crop growth model and calculated by assimilating the model with leaf area index (LAI), which was derived from time-series HJ1-CCD data. The stress levels are not constant with rice growth; thus, to improve the reliability, the two stress indices were obtained at both the first and the latter half periods of rice growth. To compare the stress indices of different stress levels, a synthetic stress index was established by combining the two indices; then, three types of stress index discriminant spaces based on the synthetic index of different growth periods were constructed, in which the two-dimensional discriminant space based on two growth periods showed the highest accuracy, with a misjudgment rate of 4.5%. When the discrimination rules were applied at a regional scale, the average correct discrimination rate was 95.0%.