Miracle-dz/UniFAR-FTUs huggingface dataset:
Natural compounds targeting glycolysis as promising therapeutics for gastric cancer: A review

Gastric cancer, a common malignant disease, seriously endangers human health and life. The high mortality rate due to gastric cancer can be attributed to a lack of effective therapeutic drugs. Cancer cells utilize the glycolytic pathway to produce energy even under aerobic conditions, commonly referred to as the Warburg effect, which is a characteristic of gastric cancer. The identification of new targets based on the glycolytic pathway for the treatment of gastric cancer is a viable option, and accumulating evidence has shown that phytochemicals have extensive anti-glycolytic properties. We reviewed the effects and mechanisms of action of phytochemicals on aerobic glycolysis in gastric cancer cells. Phytochemicals can effectively inhibit aerobic glycolysis in gastric cancer cells, suppress cell proliferation and migration, and promote apoptosis, via the PI3K/Akt, c-Myc, p53, and other signaling pathways. These pathways affect the expressions of HIF-1α, HK2, LDH, and other glycolysis-related proteins. This review further assesses the potential of using plant-derived compounds for the treatment of gastric cancer and sheds insight into the development of new drugs.
Exploring Learning Context Effects and Grapho(-Phonic)-Phonological Priming in Trilinguals

A growing body of research on bilingual word recognition suggests that lexical access is language non-selective in nature. This claim aligns with the Dynamic Systems Theory (DST) approach to (multilingual) language acquisition, according to which complex systems involve a large number of elements that interact. In language learners, these interactions lead to the creation and dissolution of patterns as the tasks and environments around them change. In this study, we extend the scope from previous research on word recognition to include the role immersion plays on the transfer of grapho(-phonic)-phonological patterns among (Brazilian Portuguese–French–English) trilinguals. Two groups of participants—one group living in their L1 environment and the other in an L2 setting—were presented with a primed lexical decision task. Besides revealing a high impact of L2 immersion on the processing of grapho(-phonic)-phonological related primes, our results provide further support for the notion of language non-selective access to the lexicon, which seems to generalize to trilingual word recognition. Implications for the DST view of multiple language acquisition are briefly discussed.
Intentions to Enhance Tourism in Private Households: Explanation and Mediated Effects of Entrepreneurial Experience

Abstract In two remote regions in the Caucasus (Georgia), the tourism sector gains importance as a source of income. Based on the theory of planned behaviour (Ajzen, 1991), a structural equation model was applied to explore the factors that determine the intentions of private households to enhance their activities in the tourism sector. The strongest influence was exerted by subjective norm followed by perceived behavioural control. Underlying beliefs showed that the family had the strongest influence on subjective norm, suggesting that interventions should also target the social environment. Furthermore, bank loans can foster the perceived ability of enhancing touristic activities while personal illness was perceived as a significant threat. The background factor, experience, indirectly influenced the intention to enhance touristic activities.
A Drosophila model for Meniere’s disease: Dystrobrevin is required for support cell function in hearing and proprioception

Meniere’s disease (MD) is an inner ear disorder characterised by recurrent vertigo attacks associated with sensorineural hearing loss and tinnitus. Evidence from epidemiology and Whole Exome Sequencing (WES) suggests a genetic susceptibility involving multiple genes, including α-Dystrobrevin (DTNA). Here we investigate a Drosophila model. We show that mutation, or knockdown, of the DTNA orthologue in Drosophila, Dystrobrevin (Dyb), results in defective proprioception and impaired function of Johnston’s Organ (JO), the fly’s equivalent of the inner ear. Dyb and another component of the dystrophin-glycoprotein complex (DGC), Dystrophin (Dys), are expressed in support cells within JO. Their specific locations suggest that they form part of support cell contacts, thereby helping to maintain the integrity of the hemolymph-neuron diffusion barrier, which is equivalent to a blood-brain barrier. These results have important implications for the human condition, and notably, we note that DTNA is expressed in equivalent cells of the mammalian inner ear.
A Linguistic Analysis of Selected Morpho-syntactic Features of Spoken Mandarin

This dissertation carries out a linguistic analysis of three selected morpho-syntactic features of Modern Standard Chinese using a corpus of spoken data. It aims to contribute to a better understanding of Mandarin Chinese grammar by making two quite different contributions to the body of research. Firstly, it provides a reconceptualised analysis of the existing literature on morpho-syntactic language change in Modern Standard Chinese, which is presented both diagrammatically and in textual form. The reconceptualisation of previous findings reveals some important and interesting correlations and connections that were not immediately obvious from the existing literature, owing to the disparate and ad hoc nature in which they have often been presented. It is hoped that a flow-on effect of this unified classification schema will be to encourage a more systematic, organised and manageable approach to conducting and reporting on future research into Chinese morpho-syntactic language change. The second contribution is a detailed grammatical analysis of selected morpho-syntactic features of Mandarin Chinese, which is carried out using a corpus of spoken data assembled especially for the purposes of this research. The corpus consists of transcripts of the chat show ‘A Date with Luyu’ broadcast between January and September 2011, and totals over 500,000 characters in size.
Tracking changes in everyday experiences of disability and disability sport within the context of the 2012 London Paralympics

The 2012 Paralympics was the biggest ever, the most accessible and best attended in its 64-year history. The Paralympics and ideas of disability associated with the Games provide significant opportunity for reflection on how far societal opinions, attitudes and behaviour have changed regarding disability. In 2012 – the first ever “legacy games” – an explicit aim of the Paralympics was to “transform the perception of disabled people in society”, (Channel 4), and use sport to contribute to “a better world for all people with a disability” (IPC 2011). The 2012 Games therefore came with a social agenda: to challenge the current perceptions many people have about disability and disability sport. Within this report – commissioned by the UK’s Paralympic broadcaster, Channel 4 – we consider everyday experiences of disability and disability sport within the context of the London 2012 Paralympics and televised coverage of the Games. The analysis is based 140 in-depth interviews that took place in the UK over a period of eighteen months, during the lead up to, and immediately after, the Games: between January 2011 and September 2012. Embedded in the lifeworld of our participants, we ask whether the 2012 Paralympics was successful in changing perceptions of disability.
An Updated Review of (Sub-)Optimal Diversification Models

In the past decade many researchers have proposed new optimal portfolio selection strategies to show that sophisticated diversification can outperform the na\"ive 1/N strategy in out-of-sample benchmarks. Providing an updated review of these models since DeMiguel et al. (2009b), I test sixteen strategies across six empirical datasets to see if indeed progress has been made. However, I find that none of the recently suggested strategies consistently outperforms the 1/N or minimum-variance approach in terms of Sharpe ratio, certainty-equivalent return or turnover. This suggests that simple diversification rules are not in fact inefficient, and gains promised by optimal portfolio choice remain unattainable out-of-sample due to large estimation errors in expected returns. Therefore, further research effort should be devoted to both improving estimation of expected returns, and possibly exploring diversification rules that do not require the estimation of expected returns directly, but also use other available information about the stock characteristics.
Altered cerebellar functional connectivity in chronic subcortical stroke patients

Background Previous studies demonstrated that cerebellar subregions are involved in different functions. Especially the cerebellar anterior lobe (CAL) and cerebellar posterior lobe (CPL) have been postulated to primarily account for sensorimotor and cognitive function, respectively. However, the functional connectivity (FC) alterations of CAL and CPL, and their relationships with behavior performance in chronic stroke participants are unclear so far. Materials and methods The present study collected resting-state fMRI data from thirty-six subcortical chronic stroke participants and thirty-eight well-matched healthy controls (HCs). We performed the FC analysis with bilateral CAL and CPL as seeds for each participant. Then, we detected the FC difference between the two groups by using a two-sample t-test and evaluated the relationship between the FC and scores of motor and cognitive assessments across all post-stroke participants by using partial correlation analysis. Results The CAL showed increased FCs in the prefrontal cortex, superior/inferior temporal gyrus, and lingual gyrus, while the CPL showed increased FCs in the inferior parietal lobule, precuneus, and cingulum gyrus in the stroke participants compared with HCs. Moreover, the FC alteration in the right CAL and the right CPL were negatively correlated with executive and memory functions across stroke participants, respectively. Conclusion These findings shed light on the different increased FC alteration patterns of CAL and CPL that help understand the neuro-mechanisms underlying behavior performance in chronic stroke survivors.
Identification of a naturally-occurring canine model for early detection and intervention research in high grade urothelial carcinoma

Background Early detection and intervention research is expected to improve the outcomes for patients with high grade muscle invasive urothelial carcinoma (InvUC). With limited patients in suitable high-risk study cohorts, relevant animal model research is critical. Experimental animal models often fail to adequately represent human cancer. The purpose of this study was to determine the suitability of dogs with high breed-associated risk for naturally-occurring InvUC to serve as relevant models for early detection and intervention research. The feasibility of screening and early intervention, and similarities and differences between canine and human tumors, and early and later canine tumors were determined. Methods STs (n=120) ≥ 6 years old with no outward evidence of urinary disease were screened at 6-month intervals for 3 years with physical exam, ultrasonography, and urinalysis with sediment exam. Cystoscopic biopsy was performed in dogs with positive screening tests. The pathological, clinical, and molecular characteristics of the “early” cancer detected by screening were determined. Transcriptomic signatures were compared between the early tumors and published findings in human InvUC, and to more advanced “later” canine tumors from STs who had the typical presentation of hematuria and urinary dysfunction. An early intervention trial of an oral cyclooxygenase inhibitor, deracoxib, was conducted in dogs with cancer detected through screening. Results Biopsy-confirmed bladder cancer was detected in 32 (27%) of 120 STs including InvUC (n=29, three starting as dysplasia), grade 1 noninvasive cancer (n=2), and carcinoma in situ (n=1). Transcriptomic signatures including druggable targets such as EGFR and the PI3K-AKT-mTOR pathway, were very similar between canine and human InvUC, especially within luminal and basal molecular subtypes. Marked transcriptomic differences were noted between early and later canine tumors, particularly within luminal subtype tumors. The deracoxib remission rate (42% CR+PR) compared very favorably to that with single-agent cyclooxygenase inhibitors in more advanced canine InvUC (17-25%), supporting the value of early intervention. Conclusions The study defined a novel naturally-occurring animal model to complement experimental models for early detection and intervention research in InvUC. Research incorporating the canine model is expected to lead to improved outcomes for humans, as well as pet dogs, facing bladder cancer.
Prediction of live birth in vitrified-warmed 1PN-derived blastocyst transfer: Overall quality grade, ICM, TE, and expansion degree

Background: Numerous studies have reported that transfer of blastocysts derived from monopronuclear (1PN) zygotes achieved live births. However, the potential value of morphology grading for the prediction of 1PN blastocyst viability is unclear, and the blastocyst selection criterion for successful pregnancy has not been set up yet. The aim of this study is to assess the ability of the blastocyst morphology grading system based on three parameters, namely, inner cell mass (ICM), trophectoderm (TE), and expansion degree and to predict outcomes of a cycle with single 1PN blastocyst transfer. Methods: A total of 266 vitrified-warmed 1PN-derived blastocyst transfer cycles for IVF treatment at Shanghai Ninth People’s Hospital between 2007 and 2020 were included. The study was performed on single blastocyst transfers. Electronic records of patients were retrospectively analyzed. In the current study, the blastocysts were classified into three groups: “good,” 3-6AA, 3-6AB, 3-6BA; “medium,” 3-6BB, 3-6AC, 3-6CA; and “poor,” 3-6BC, 3-6CB, 3-6CC. The basal characteristics, embryo grading, and clinical outcomes were compared between the three groups. The association of morphology parameters with pregnancies and live births was analyzed. Logistic regression was adopted to set up a prediction model of live births. Results: Transfer of the good-quality blastocysts achieved significant higher pregnancies (biochemical pregnancy: 59%; clinical pregnancy: 56.4%, and live birth 48.7%) than those in the group of the medium (biochemical pregnancy: 59%; clinical pregnancy: 49.6%; live birth: 40.4%) or poor-quality (biochemical pregnancy: 38.4%; clinical pregnancy: 34.9%; live birth: 26.7%) blastocysts (p < 0.05). There was a significant association between ICM and live birth. A prediction model of live births involving ICM, TE, and expansion degree was set up. Conclusion: In 1PN transfer cycles, a higher overall blastocyst quality is shown to correlate most strongly with optimal pregnancy and live birth outcomes. The selection of high-quality blastocysts for transfer should consider the ICM score first. The prediction model of live births based on ICM, TE, and expansion degree may help predict successful pregnancy in 1PN single-blastocyst transfer cycles.
Chronic heat stress part 1: Decrease in egg quality, increase in cortisol levels in egg albumen, and reduction in fertility of breeder pekin ducks

Global warming poses detrimental effects on poultry production leading to substantial economic losses. The goal of our experiment was to test the hypothesis that heat stress (HS) would alter welfare and egg quality (EQ) of breeder ducks. Furthermore, we wanted to test if HS would increase cortisol levels in egg albumen. Adult Pekin ducks were randomly assigned to two different rooms at 85% lay with 60 hens and 20 drakes per room. Baseline data including body weight, body condition scores (BCS), and egg production/quality were collected the week preceding heat treatment. Ducks were subjected to cyclic HS of 35°C for 10h/day and 29.5°C for the remaining 14h/day for 3 weeks while the control room was maintained at 22°C. Eggs were collected daily and analyzed weekly for quality assessment, and for albumen glucocorticoid (GCs) levels using mass spectrometry. One week before the exposure to HS, 10 hens and 5 drakes were euthanized and the same number again after 3 weeks and birds necropsied. Data analyses were done by 1- or 2-way ANOVA as appropriate with a Tukey-Kramer post hoc test. BCS were analyzed using a chi-squared test. A p ≤ 0.05 was considered significant. Circulating levels of corticosterone were significantly (p < 0.01) elevated at week 1 only in the HS hens. The circulating levels of cortisol increased significantly at week 1 and 2 (p < 0.05), and week 3 (p < 0.01) in the hens and at weeks 2 and 3 only (p < 0.05) in the drakes. Feather quality scores (p < 0.01), feather cleanliness scores (p < 0.001) and footpad quality scores (p < 0.05) increased significantly in the HS group. HS elicited a significant (p < 0.001) decrease in egg production at weeks 1 and 3. Hens in the HS group showed significantly decreased BW (p < 0.001) and number of follicles (p < 0.05). Shell weight decreased significantly at week 1 only (p < 0.05) compared to controls. Yolk weight decreased significantly at week 3 (p < 0.01) compared to controls. HS elicited a significant increase in albumen cortisol levels at week 1 (p < 0.05) and week 3 (p < 0.05). Thus, cortisol may provide critical information to further understand and to improve welfare.
Problematic Eating Interventions in Out-of-Home Care: The Need for a Trauma-Informed, Attachment-Focused Approach

ABSTRACT Problematic eating interventions targeting young people living in out-of-home care (OoHC) have been neglected. Therefore, the aim of this narrative literature review was threefold: (1) to identify the state of the literature regarding interventions that address subclinical and clinical problematic eating behaviours among young people in OoHC; (2) to evaluate problematic eating interventions that have been developed for young people in the general population; and (3) to assess the extent to which these general interventions can be translated and implemented for young people in OoHC. This study found no interventions specifically designed for young people in OoHC. While there is the potential for current problematic eating interventions to be translated for this cohort, major adaptions are required in which both trauma-informed and attachment-focused perspectives are seen as central factors to problematic eating interventions in OoHC. IMPLICATIONS There are significant practical and theoretical limitations of administering current problematic eating interventions to young people living in OoHC. Interventions combining the theoretical underpinnings of Cognitive Behavioural Therapy and Mentalisation-Based Therapy for Eating Disorders may begin to address the risk factors for problematic eating among young people in OoHC. A trauma-informed, attachment-focused problematic eating intervention is needed for young people in OoHC.
How Prevalent is Downward Rigidity in Nominal Wages? International Evidence from Payroll Records and Pay Slips

For more than 80 years, many macroeconomic analyses have been premised on the assumption that workers’ nominal wage rates cannot be cut. Contrary evidence from household surveys reasonably has been discounted on the grounds that the measurement of frequent wage cuts might be an artifact of reporting error. This article summarizes a more recent wave of studies based on more accurate wage data from payroll records and pay slips. By and large, these studies indicate that, except in extreme circumstances (when nominal wage cuts are either legally prohibited or rendered beside the point by very high inflation), nominal wage cuts from one year to the next appear quite common, typically affecting 15–25 percent of job stayers in periods of low inflation.
The Effectiveness of Online and Paper-Based Formative Assessment in the Learning of English as a Second Language.

This article investigates the relative effectiveness of online and paper-based formative assessment in the learning of English as a second language. For this study, 74 Japanese university second language (L2) students took online quizzes, while 71 were given paper-based quizzes to complete. The quiz content was drawn from learning material found in the class textbook. Both groups were assigned the exercises as homework. At the end of the 15-week study period, both groups were administered a summative assessment that also covered learning points from the textbook. After controlling for the learners' L2 proficiency through their TOEIC test scores, the performance of the two groups on the formative quiz was compared through correlation and regression analysis. While there was found to be a statistically significant relationship between the online formative assessment and summative exam scores, this was not the case for the paper-based homework. When compared through an analysis of covariance, there was found to be a significant interaction between group and homework on exam scores. The online group was more affected by their homework score than the pencil and paper group. The findings from this study have implications for teachers, learners and curriculum developers.
Recurrent Encoder Multi-Decoder Networks, Semi-supervised Classification and Constrained Adversarial Generation

We explore recurrent encoder multi-decoder neural network architectures for semi-supervised sequence classification and reconstruction. We find that the use of multiple reconstruction modules helps models generalize. Our experiments are conducted on two well known Motion Capture data sets. We also explore a novel formulation for future predicting decoders based on conditional recurrent generative adversarial networks. Further our networks have both soft and hard constraints derived from desired physical properties of synthesized future movements and desired animation goals. We find that networks with these properties reduce common artifacts in generated sequences compared to using simpler architectures.
Development of an Adaptive Hybrid Algorithm for Congestion Control andBandwidth Utilization in a Mobile Network

This research work developed an adaptive algorithm that hybridizes call admission control, bandwidth degradation and load balancing congestion control techniques to improve bandwidth utilization and minimize congestion in mobile network. The developed hybrid algorithm is implemented using NetBeans IDE 6.9. 1 platform to obtain performance metrics of blocking probability of new calls and dropping probability of handover calls. The simulation results obtained from the model recorded the New Call Blocking Probability (NCBP) of 0.003 and Handover Call Droppping Probability (HCDP) of 0.001. The developed model’s NCBP was better than the ITU-T benchmark standard of 0.01 and matched that of the HCDP of 0.001. Also, real life results from measured data of Etisalat mobile network and simulated data results of the developed model were validated using statistical Welch’s TTest. The probability levels (p-values) of 0.034 for NCBP and 0.001 for HCDP obtained from T-Test, which are less than 0.05 imply that NCBP and HCDP reject the null hypothesis. Hence, there is significant difference between the developed hybrid model and existing model from Etisalat mobile network at 95% confidence level, which also indicates that the developed model has better performance.