Miracle-dz/UniFAR-FTUs huggingface dataset:
A Scalable Architecture for Real-Time Stream Processing of Spatiotemporal IoT Stream Data - Performance Analysis on the Example of Map Matching

Scalable real-time processing of large amounts of data has become a research topic of particular importance due to the continuously rising amount of data that is generated by devices equipped with sensing components. While existing approaches allow for fault-tolerant and scalable stream processing, we present a pipeline architecture that consists of well-known open source tools to specifically integrate spatiotemporal internet of things (IoT) data streams. In a case study, we utilize the architecture to tackle the online map matching problem, a pre-processing step for trajectory mining algorithms. Given the rising amount of vehicle location data that is generated on a daily basis, existing map matching algorithms have to be implemented in a distributed manner to be executable in a stream processing framework that provides scalability. We demonstrate how to implement state-of-the-art map matching algorithms in our distributed stream processing pipeline and analyze measured latencies.
Applying COM-B to medication adherence

On average only fifty percent of people with long term conditions are adherent to their treatment across diverse disease and patient groups (Holloway & van Dijk, 2011; Sabaté, 2003). Medication non-adherence leads to reduced clinical benefit, avoidable morbidity and mortality and medication wastage (DiMatteo, Giordane, Lepper, & Croghan, 2002). With increases in life expectancies as well as the number of patients managing chronic illnesses, this problem may well become worse in the next few years. Consequently, policy makers have called for successful interventions to address the causes of non-adherence and improve the population’s use of medicines (Holloway & van Dijk, 2011; Horne, Weinman, Barber, Elliott, & Morgan, 2006; Nunes et al. , 2009; Sabaté, 2003). Indeed, it has been estimated that $269 billion worldwide could be saved by improving patient medication adherence (IMS Institute for Healthcare Informatics, 2012). Unfortunately, many adherence interventions to date have not been effective (Haynes, Ackloo, Sahota, McDonald, & Yao, 2008). Medical Research Council guidelines recommend that appropriate theory and evidence should be identified to inform the development of an intervention (Craig et al. , 2008). However, most adherence interventions are developed without a sound theoretical base, which may be one of the reasons they have not been effective (Horne et al. , 2006). Successful interventions have often involved a level of complexity that would be too difficult and expensive to implement in practice (Haynes et al. , 2008). Explanations and models of medication adherence/non-adherence have changed over the years. Early work tended to focus on the role of doctor-patient communication and its effects on patient satisfaction, understanding and forgetting as key determinants of subsequent treatment adherence (Ley, 1988). However, health behaviour research has consistently demonstrated that the provision of information alone is not an effective way to change behaviour, and so research has now moved onto approaches and models which focus on patients’ beliefs, motivation and planning abilities as the core explanatory variables. Many of these are social cognition or self-regulatory models which emphasize the importance of the beliefs which individuals have about their illness and treatment as well as their own ability to follow the treatment and advice which they are given (see Conner & Norman, 2005). Existing models and frameworks are not comprehensive since they neglect automatic processes such as habit (for example, Ajzen, 1985; Bandura, 1977, 1986; Horne, 1997, 2003; Leventhal, Nerenz, & Steele, 1984; Pound et al. , 2005; Rosenstock, 1974), do not describe dynamic behaviours whereby the experience of adherence/non-adherence can alter predisposing factors such as beliefs about medication (for example, Ajzen, 1985; Bandura, 1977, 1986; Horne, 2003; Pound et al. , 2005; Rosenstock, 1974) and neglect factors at a systems level (for example, Horne, 2000, 2003; Leventhal et al. , 1984; Pound et al. , 2005; Rosenstock, 1974). In addition, the often used Christina Jackson
Matching with Quotas

The paper characterizes the core of many-to-one matching problem with quotas. The many-to-one matching problem with quotas may have an empty core, and there is no clear set of necessary and sufficient conditions that guarantee non-emptiness of the core. Usual sufficient conditions for non-emptiness of the core for matching problems cannot be applied for the problem with quotas. We introduce set strong substitutability of preferences, a refinement of strong substitutability for the problem with quotas. We show that if preferences are set strongly substitutable, then the core of many-to-one matching problem with quotas is non-empty. Moreover, we prove that in this case the core has a lattice structure with opposition of interests. Length: 16
Cell-Cell Communication Networks Propose a Modulation of the Hematopoietic Stem Cell Niche by Invading Breast Carcinoma Cells

Background: The human bone marrow can become a target of disseminated tumor cells in a relevant proportion of breast cancer patients. However, the underlying pathophysiology is incompletely understood. This study aims to identify and characterize potential mechanisms modulating the bone marrow hematopoietic microenvironment by invading breast cancer cells (BCC) as a basis for experimental evaluation. Methods: Static cell-cell communication networks, representing the integrated signaling among breast carcinoma cell lines (MCF-7 or MDA-MB-231), bone marrow-derived mesenchymal stromal cells (MSC) and hematopoietic stem and progenitor cells (HSPC), were constructed in-silico by combining differentially overexpressed genes of the involved cell populations with known ligand-receptor interactions. Using the networks as guidance, pathophysiological relevance of the analyzed populations to breast cancer-initiated hematologic abnormalities was appraised by systematic literature mining. In-vitro co-culture modeling was performed to evaluate the paracrine effects of BCC on MSC-HSPC signaling and to validate main implications of the exposed signaling network. Results: Breast cancer cells exhibited intensive bidirectional intercellular signaling with MSC and to a lesser extent with HSPC. BCC-derived signals were reported to recruit MSC to sites of breast cancer, activate tumor associated fibroblasts (TAF) and modify MSC differentiation. Hematopoietic microenvironment-derived signals were predominantly associated with BCC attraction and metastatic progression. Potential ligands that protect from metastases were exclusively HSPCderived. In-vitro co-culture modeling revealed that BCC mediated loss of the niche-derived hematopoiesis-supporting factor SDF-1 and the emergence of FGF-2 in the MSC-HSPC interaction. Conclusion: We propose a modulation of MSC by BCC, inter alia via the FGF-2/FGFR1 pathway, resulting in activation of TAF, generation of a vascularized tumor stroma, breast cancer progression and consequential impairment of hematopoiesis by reduction of SDF-1 levels. Those indirect changes in the HSC niche upon BCC invasion might increase the vulnerability for bone metastasis in breast cancer patients.
Chondroblastoma of the Lumbar Spine - A Case Report and Review of the Literature -

We report a case of chondroblastoma arising in the lumbar spine in a 25-year-old man who presented with low back pain of 5 years duration. Plain radiography and computed tomography revealed a well-defined osteolytic mass surrounded by marginal sclerosis in the third lumbar verte bra. The mass encroached on the left neural foramen on magnetic resonance imaging. Histologically, the tumor consisted of round to oval cells with eosinophilic cytoplasm and randomly scattered osteoclastic type giant cells. There were characteristic chicken-wire calcification and aneu rysmal bone cyst-like changes. Chondroblastomas of the lumbar spine are extremely rare, and only nine cases have been reported. Spinal chondroblastoma should be distinguished from other benign bone tumors, because it tends to show aggressive biological behavior with high recurrence and mortality rates.
The polarization of HD 189733

Kimberly Bott; Jeremy Bailey; Lucyna Kedziora-Chudczer; Daniel V. Votton; P. W. Lucas; Jonathan P. Marshall; J. H. Hough, ‘The polarization of HD 189733’, Monthly Notices of the Royal Astronomical Society/Letters, Vol 459(1): L109-L113, published 20 March 2016, the version of record is available online at doi: https://doi.org/10.1093/mnras/slw046 © 2016 The Authors. Published by Oxford University Press on behalf of the Royal Astronomical Society.
Sub-Optimal Kalman Filter for Multimodeling Systems

In this paper, we study the optimal Kalman filtering problem for multiparameter singularly perturbed system (MSPS). The attention is focused on the design of the high–order approximate Kalman filters. It is shown that the resulting filters in fact remove ill–conditioning of the original full–order singularly perturbed Kalman filters. In addition the resulting filters can be used compared with the previously proposed result even if the Hamiltonian matrices for the fast subsystems have eigenvalues in common.
THE CONTRIBUTIONS O F CLARK P. READ ON THE ECOLOGY OF THE VERTEBRATE GUT AND ITS PARASITES by George

Clark Read's scientific contributions had great impact on the discipline of parasitology and on biology as a whole. It was Read, more than any other worker, who articulated the concept of the host-parasite interface and defined many of the intricate molecular interactions between symbiotes and their hosts. As Justus Mueller, editor of the Journal of Parasitology, recently stated, "Clark Read was Parasitology's ambassador to the fields of physiology, biochemistry and molecular biology. " Some of Read's greatest contributions dealt with physiological interactions between intestinal-parasitic helminths and the vertebrate gut, and it is to these works that the following paragraphs are addressed. In 1950, while a graduate student at the Rice Institute, Clark Read completed a monograph entitled The Vertebrate Small Intestine as an Environment for Parasitic Helminths, in which he dealt with the parameters of intestinal physiology of greatest importance to the parasitologist. In this publication Read devoted particular attention to the dynamics of the intestinal environment. He considered contributions made to the gut contents by the stomach, liver, pancreas, and intestinal mucosa, with special reference to the importance of these organs in conditioning the gut lumen as an environment for parasites. He presented strong support for the existence of an exocrino-enteric circulation involving the flow of materials, with the notable exception of carbohydrates, from the blood and from other organs into the lumen of the vertebrate intestine, and subsequent resorption of these materials by the intestine. Read concluded that this flow of organic compounds from the tissues, much of which would be resorbed in areas of the gut distal to the point of secretion, would be available to lumen-dwelling parasites. In addition, Read emphasized the existence of lateral variation in the physico-chemical conditions of the
Tumor-Driving Signal Transduction Pathways Knowledge-Based Computational Models That Identify Selection of Personalized Patient Therapy through the Use of

Increasing knowledge about signal transduction pathways as drivers of cancer growth has elicited the development of "targeted drugs," which inhibit aberrant signaling pathways. They require a companion diagnostic test that identifies the tumor-driving pathway; however, currently available tests like estrogen receptor (ER) protein expression for hormonal treatment of breast cancer do not reliably predict therapy response, at least in part because they do not adequately assess functional pathway activity. Wedescribeanovel approach topredict signaling pathway activity based on knowledge-based Bayesian computationalmodels, which interpret quantitative transcriptome data as the functional output of an active signaling pathway, by using expression levels of transcriptional target genes. Following calibration on only a small number of cell lines or cohorts of patient data, they provide a reliable assessment of signaling pathway activity in tumors of different tissue origin. As proof of principle, models for the canonical Wnt and ER pathways are presented, including initial clinical validation on independent datasets from various cancer types. Cancer Res; 74(11); 2936–45. 2014 AACR.
Empowerment: hotel employees’ perspective

An empowered worker is a knowledgeable worker. Thus, the aims of this study were to examine how empowerment is perceived by the front-line hotel employees and secondly, to identify the factors affecting empowerment within the industry. Factors such as communication, coaching, participation, training and reward were examined for any significant relationship with empowerment, along with whether the employee’s socio-demographic characteristics affected their perceptions of empowerment. The findings indicated that except for gender, socio-demographic factors were not a strong influence on the diffusion of empowerment among employees. In order to ensure that the employees feel empowered, factors such as communication, coaching, participation, training and reward should be given due attention by the management. Based on the findings, implications for companies are discussed and further research is suggested.
Prevalence of βS-globin gene haplotypes, α-thalassemia (3.7 kb deletion) and redox status in patients with sickle cell anemia in the state of Paraná, Brazil

The aim of this study was to determine the frequency of beta S-globin gene (βS globin) haplotypes and alpha thalassemia with 3.7 kb deletion (−α3.7kb thalassemia) in the northwest region of Paraná state, and to investigate the oxidative and clinical-hematological profile of βS globin carriers in this population. Of the 77 samples analyzed, 17 were Hb SS, 30 were Hb AS and 30 were Hb AA. The βSglobin haplotypes and −α3.7kb thalassemia were identified using polymerase chain reaction.Trolox equivalent antioxidant capacity (TEAC) and lipid peroxidation (LPO) were assessed spectophotometrically. Serum melatonin levels were determined using high-performance liquid chromatography coupled to coulometric electrochemical detection. The haplotype frequencies in the SS individuals were as follows: Bantu- 21 (62%), Benin - 11 (32%) and Atypical- 2 (6%). Bantu/Benin was the most frequent genotype. Of the 47 SS and AS individuals assessed, 17% (n = 8) had the −α3.7kb mutation. Clinical manifestations, as well as serum melatonin, TEAC and LPO levels did not differ between Bantu/Bantu and Bantu/Benin individuals (p > 0.05). Both genotypes were associated with high LPO and TEAC levels and decreased melatonin concentration. These data suggest that the level of oxidative stress in patients with Bantu/Bantu and Bantu/Benin genotypes may overload the antioxidant capacity.
AN ARTICULATORY AND ACOUSTICAL ANALYSIS OF THE SYLLABLE- INITIAL SIBILANTS AND APPROXIMANT IN BEIJING MANDARIN

This paper is an articulatory and acoustical analysis of the syllable-initial sibilants and approximant in Beijing Mandarin. Palatograms and linguagrams were obtained from young adult native speakers of Beijing, male and female, using the direct method. Results show that the initial consonants which are transcribed in earlier studies [3, 4, 10] as retroflexes [§, t§, 1⁄2( ̈)] are in fact apical or upperapical postalveolar fricative [SÁ], affricate [tSÁ], and approximant [ ̈Á], respectively. Those as palatal sibilants [] and [t] are in fact laminal or anterodorsal alveolar-postalveolar or postalveolar fricative [S4] and affricate [tS4]. The frequency of the spectral energy is the highest for [s, ts], followed by [S4, tS4] and [SÁ, tSÁ] in decreasing order. The spectrum lengths of the sibilants are longer for the female speakers than the male speakers. The pattern of the Fvalues for [ Á̈ ] for the female speakers differs from the pattern for the male speakers.
Purple Nutsedge (Cyperus rotundus) Population Dynamics in Narrow Row Transgenic Cotton (Gossypium hirsutum) and Soybean (Glycine max) Rotation1

A 4-yr field study was conducted during 1998 through 2001 at Stoneville, MS, to determine the effects of narrow-row transgenic cotton and soybean rotation on purple nutsedge populations and crop yield. Crop rotations over 4 yr included cotton and soybean sown in the following patterns: CCSS, CSCS, SCSC, SSCC, and continuous cotton (CCCC) and soybean (SSSS), where cotton is denoted as (C) and soybean as (S), all with herbicide programs that were glyphosate based, non–glyphosate based, or no purple-nutsedge control (NPNC). Purple nutsedge populations and shoot dry biomass were reduced in cotton and soybean rotation and continuous soybean by 72 and 92%, respectively, whereas in continuous cotton, purple nutsedge populations increased by 67% and shoot dry biomass was reduced by 32% after 4 yr. Reductions in purple nutsedge populations also occurred in soybean when cotton was rotated with soybean (CSCS and SCSC), compared with continuous cotton. Among herbicide programs, the glyphosate-based program was more effective in reducing purple nutsedge populations, compared with the non–glyphosate-based program. Seed cotton yield was greater with cotton following soybean (SCSC) than with cotton following cotton (CCCC, CCSS) in 1999. However, seed cotton yields were similar regardless of crop rotation systems in 2000 and 2001. Seed cotton yields were equivalent in the glyphosate-based and non–glyphosate-based programs in 1999 and 2001. During 1999 to 2001, seed cotton yields were reduced by 62 to 85% in NPNC compared with yields in glyphosate- and non–glyphosate-based programs. Soybean yields were unaffected by crop rotation systems in all the 4 yr. Among herbicide programs, non–glyphosate-based program in all 4 yr and glyphosate-based program in 1999 and 2000 gave higher soybean yield compared with NPNC. After 4 yr of rotation, purple nutsedge tubers and plant density were highest in continuous cotton and lowest in continuous soybean. Both herbicide programs reduced tubers per core and plant density compared with NPNC, and the glyphosate-based program was more effective than the non–glyphosate-based program. These results show that in cotton production, severe infestations of purple nutsedge can be managed by rotating cotton with soybean or by using glyphosate-based herbicide program in glyphosate-resistant cotton. Nomenclature: Glyphosate; purple nutsedge, Cyperus rotundus L. #3 CYPRO; cotton, Gossypium hirsutum L. ‘DP 436RR’; soybean, Glycine max (L.) Merr. ‘DP 5806RR’. Additional index words: Purple nutsedge tuber, transgenic crop. Abbreviations: fb, followed by; NPNC, herbicide program with no purple-nutsedge control; POST, postemergence; PPI, preplant incorporated; PRE, preemergence.
Rate Regulation, Safety Incentives, and Loss Growth in Workers' Compensation Insurance

We analyze the relationship between insurance rate regulation, inflationary cost surges, and incentives for loss control using state-level data on workers' compensation insurance for 24 states during 1984-90. Regulators often responded to rapid loss growth during this period by denying rate increases or approving increases that were less than initially requested by insurers. We test whether rate suppression increased loss growth by distorting incentives for loss control. Our regressions indicate a positive and statistically reliable relationship between loss growth and lagged measures of regulatory price constraints, suggesting that rate regulation increased the frequency and/or severity of employee injuries. Copyright 2000 by University of Chicago Press.
Sample Path Properties of Volterra Processes

We consider the regularity of sample paths of Volterra processes. These processes are defined as stochastic integrals $$ M(t)=\int_{0}^{t}F(t,r)dX(r), \ \ t \in \mathds{R}_{+}, $$ where $X$ is a semimartingale and $F$ is a deterministic real-valued function. We derive the information on the modulus of continuity for these processes under regularity assumptions on the function $F$ and show that $M(t)$ has "worst" regularity properties at times of jumps of $X(t)$. We apply our results to obtain the optimal H\"older exponent for fractional L\'{e}vy processes.
Comparative Analysis of MicroRNA Expression in Three Paulownia Species with Phytoplasma Infection

Paulownia witches’ broom (PaWB), caused by phytoplasma, is an important disease of Paulownia. To further identify the key miRNAs associated with the formation of PaWB symptoms, miRNA and degradome sequencing were performed to explore important miRNAs–target regulation in healthy and diseased Paulownia tomentosa, Paulownia fortunei, and P. tomentosa × P. fortunei seedlings, and the corresponding diseased seedlings treated with 75 mg L−1 dimethyl sulfate. A total of 212, 111, and 197 differentially expressed miRNAs (DEMs) were obtained in P. tomentosa, P. fortunei, and P. tomentosa × P. fortunei, respectively. Degradome sequencing detected 559, 251, and 568 target genes of the DEMs in P. tomentosa, P. fortunei, and P. tomentosa × P. fortunei, respectively. The expression patterns of selected miRNAs and the target genes were verified be qRT-PCR. Through analysis of the expression level of the DEMs in this study, combined with the results in our previous studies, as well as with those reported in other phytoplasma-infected plants, we concluded that miR156 is an important miRNA related to witches’ broom. According to the functions of the target genes of DEMs, we constructed a co-regulatory network of the DEMs-target genes interaction. These results will help to advance the understanding of the mechanism of PaWB.
3D Numerical Study of MHD Flow in a Rectangular Duct with a Flow Channel Insert

Abstract This study continues our ongoing investigation of magnetohydrodynamic (MHD) flows in poloidal ducts of the Dual-Coolant Lead-Lithium (DCLL) blanket with an insulating flow channel insert (FCI). We report our first 3D modeling results for an approximately ideally non-conducting FCI. The FCI and duct geometry match those of an experiment performed recently in Southwestern Institute of Physics (SWIP), China. The experimental FCI is made of epoxy and has a pressure equalization slot (PES) in one wall, which is perpendicular to the applied magnetic field. Previous 2D modeling efforts based on the fully developed flow model have demonstrated a significant difference with the experimental results in the MHD pressure drop, indicating 3D effects may be significant. The new 3D results, obtained with an unstructured, parallel MHD solver HIMAG, are in fair agreement with the experimental data. These results confirm a substantial reduction in MHD pressure drop by the FCI, but not as significant as would be expected under fully developed flow conditions.
Xanthoria parietina (L). TH .F R. MYCOBIONT ISOLATION BY ASCOSPORE DISCHARGE, GERMINATION AND DEVELOPMENT IN "IN VITRO" CULTURE

The article is focused on fungal partner isolation from the Xanthoria parietina (Teloschistaceae) lichen body by ascospore discharge from golden disk-like fruits - ascoma, followed by germination and subsequent development on liquid nutrient medium Malt-Yeast extract (AHMADJIAN, 1967a) under different temperature and light/dark regime conditions. The morphology of the mycobiont and the inner structure were characterized by stereomicroscope Stemi 2000 C, light microscope Scope. A1, Zeiss and by the JEOL - JSM - 6610LV Scanning Electron Microscope.