Miracle-dz/UniFAR-FTUs huggingface dataset:
Somatostatin in the brain of the cave salamander, Hydromantes genei (Amphibia, Plethodontidae): Immunohistochemical localization and biochemical characterization

The distribution of somatostatin‐like immunoreactivity in the brain of the cave salamander Hydromantes genei (Amphibia, Plethodontidae) was investigated by using two distinct antisera raised against somatostatin‐14. Most somatostatin‐positive cells were detected in the ependymal cell layer surrounding the ventricles. These cells possessed the typical morphological characteristics of tanycytes or radial glial cells. Double‐labeling with an antiserum against somatostatin and a monoclonal antibody against glial fibrillary acidic protein showed that somatostatin‐immunoreactive cells lining the ventricles also exhibited GFAP‐like immunoreactivity. Injection of the neurotracer biocytin into the lateral ventricle revealed that neurons lining the ventricles did not contain somatostatin‐like immunoreactivity. In the telencephalon, somatostatin‐like immunoreactivity was confined to radial glial cells. In the diencephalon, in addition to somatostatin‐immunoreactive cells in the ependyma, positive cell bodies were also found in the periventricular preoptic nucleus, the infundibular nucleus, the epiphysis, and the subcommissural organ. In the metencephalon, positive cell bodies were found in the auricula cerebelli, whereas in the rhombencephalon numerous somatostatin‐immunoreactive cells were seen lining the ventricular cavity. Immunoreactive nerve fibers were observed in the hypothalamus‐median eminence complex. In the pituitary, a discrete group of somatostatin‐positive cells was found in the pars distalis. High‐performance liquid chromatography analysis of brain extracts revealed that the immunoreactive material coeluted with somatostatin‐14. The present results show that the somatostatin peptidergic system in the brain of the cave salamander has a more simple organization than those described in the brain of frog and other vertebrates. This feature is probably related to the expression of high pedomorphic characters in plethodontids. The distribution of somatostatin‐like immunoreactivity suggests that, in the cave salamander, somatostatin may act as a neurotransmitter and/or neuromodulator, a central regulator of fluid homeostasis, and a hypophysiotropic neurohormone. J. Comp. Neurol. 475:163–176, 2004. © 2004 Wiley‐Liss, Inc.
Contrasting controls on wildland fires in Southern California during periods with and without Santa Ana winds

Wildland fires in Southern California can be divided into two categories: fall fires, which are typically driven by strong offshore Santa Ana winds, and summer fires, which occur with comparatively weak onshore winds and hot and dry weather. Both types of fire contribute significantly to annual burned area and economic loss. An improved understanding of the relationship between Southern California's meteorology and fire is needed to improve predictions of how fire will change in the future and to anticipate management needs. We used output from a regional climate model constrained by reanalysis observations to identify Santa Ana events and partition fires into those occurring during periods with and without Santa Ana conditions during 1959–2009. We then developed separate empirical regression models for Santa Ana and non‐Santa Ana fires to quantify the effects of meteorology on fire number and size. These models explained approximately 58% of the seasonal and interannual variation in the number of Santa Ana fires and 36% of the variation in non‐Santa Ana fires. The number of Santa Ana fires increased during years when relative humidity during Santa Ana events and fall precipitation were below average, indicating that fuel moisture is a key controller of ignition. Relative humidity strongly affected Santa Ana fire size. Cumulative precipitation during the previous three winters was significantly correlated with the number of non‐Santa Ana fires, presumably through increased fine fuel density and connectivity between infrastructure and nearby vegetation. Both relative humidity and the preceding wet season precipitation influenced non‐Santa Ana fire size. Regression models driven by meteorology explained 57% of the temporal variation in Santa Ana burned area and 22% of the variation in non‐Santa Ana burned area. The area burned by non‐Santa Ana fires has increased steadily by 1.7% year−1 since 1959 (p < 0.006); the occurrence of extremely large Santa Ana fires has increased abruptly since 2003. Our results underscore the need to separately consider the fuel and meteorological controls on Santa Ana and non‐Santa Ana fires when projecting climate change impacts on regional fire.
Community Health Workers and Use of mHealth: Improving Identification of Pregnancy Complications and Access to Care in the Dominican Republic

This article presents the feasibility and acceptability of using mobile health technology by community health workers (CHWs) in San Juan Province, Dominican Republic, to improve identification of pregnancy complications and access to care for pregnant women. Although most women in the Dominican Republic receive four antenatal care visits, poor women and adolescents in remote areas are more likely to have only one initial prenatal visit to verify the pregnancy. This community-based research began when community leaders raised concern about the numbers of their mothers who died in childbirth annually; San Juan’s maternal mortality rate is 144/100,000 compared to the Caribbean rate of 85/100,000. Eight CHWs in three communities were taught to provide third-trimester antenatal assessment, upload the data on a mobile phone application, send the data to the local physician who monitored data for “red flags,” and call directly if a mother had an urgent problem. Fifty-two pregnant women enrolled, 38 were followed to delivery, 95 antenatal care postintake were provided, 2 urgent complications required CHW home management of mothers, and there were 0 deaths. Stakeholders endorsed acceptability of intervention. Preliminary data suggest CHWs using mobile health technology is feasible, linking underserved and formal health care systems with provision of primary care in mothers’ homes.
Risk factors for neonatal sepsis in offspring of women with prelabor rupture of the membranes at 34-42 weeks

One thousand three hundred eighty-five women with PROM (prelabor rupture of the membranes) participated in a prospective randomized study. Women with PROM were randomized to induction the following morning after PROM (early induction group) or induction two days later (late induction group). If contractions started within 2 hours after admission these women were included in the short latency group. All neonatal infections were classified as verified sepsis (positive culture) or clinical sepsis. The aim of the study was to compare the perinatal infectious outcome between the groups with different expectant managements in women with PROM and to study the association between demographic, intrapartum and postpartum variables and neonatal sepsis. In the short latency group one neonate had a proven sepsis while four neonates with proven sepsis were found in the early induction group. No proven sepsis was detected in the late induction group. Univariate analyses showed a significant association between clinical sepsis and: induction of labor (OR = 2.94, 95% CI 1.30-6.68), established labor 24.1-32 hours after ROM (OR = 5.89, 95% CI 1.68-20.63), established labor > 32 hours after ROM (OR = 4.59, 95% CI 1.52-13.87), time from ROM to delivery > 32 hours (OR = 5.07, 95% CI 1.40-18.39), cesarean section (OR = 11.03, 95% CI 4.10-29.68), chorioamnionitis before or during delivery (OR = 27.14, 95% CI 2.38-309.16), endometritis (OR = 18.08, 95% CI 1.82-179.87), CRP over 20 mg/l in the umbilical cord (OR = 17.12, 95% CI 5.68-52.12) and Apgar score < 7 after 1, 5 or 10 minutes. In a stepwise logistic regression analysis a significant association was found between clinical sepsis and cesarean section (OR = 10.08, 95% CI = 3.26-31.20), time from ROM to delivery > 32 h (OR = 3.74, 95% CI 1.62-8.62), gestational age 34-36 weeks (OR = 3.16, 95% CI 1.11-8.96) and parous women (OR = 2.41, 95% CI 1.04-5.57). In conclusion, this study indicates that that there was no difference in the incidence of neonatal infections between those with early and late induction. Clinical neonatal sepsis was associated with time from PROM to delivery over 32 hours, cesarean section, parous women and gestational age between 34 and 36 weeks.
Evaluation of microbial culture of pooled fecal samples for detection of Mycobacterium avium subsp paratuberculosis in large dairy herds.

OBJECTIVE To evaluate sensitivity of microbial culture of pooled fecal samples for detection of Mycobacterium avium subsp paratuberculosis (MAP) in large dairy herds and assess the use of the method for estimation of MAP prevalence. ANIMALS 1,740 lactating cows from 29 dairy herds in California. PROCEDURE Serum from each cow was tested by use of a commercial ELISA kit. Individual fecal samples were cultured and used to create pooled fecal samples (10 randomly selected fecal samples/pool; 6 pooled samples/herd). Sensitivity of MAP detection was compared between Herrold's egg yolk (HEY) agar and a new liquid culture method. Bayesian methods were used to estimate true prevalence of MAP-infected cows and herd sensitivity. RESULTS Estimated sensitivity for pooled fecal samples among all herds was 0.69 (25 culture-positive pools/36 pools that were MAP positive). Sensitivity increased as the number of culture-positive samples in a pool increased. The HEY agar method detected more infected cows than the liquid culture method but had lower sensitivity for pooled fecal samples. Prevalence of MAP-infected cows was estimated to be 4% (95% probability interval, 2% to 6%) on the basis of culture of pooled fecal samples. Herd-level sensitivity estimate ranged from 90% to 100% and was dependent on prevalence in the population and the sensitivity for culture of pooled fecal samples. CONCLUSIONS AND CLINICAL RELEVANCE Use of pooled fecal samples from 10 cows was a cost-effective tool for herd screening and may provide a good estimate of the percentage of MAP-infected cows in dairy herds with a low prevalence of MAP.
Immunogenetic differencies between patients with familial and non-familial rheumatoid arthritis

OBJECTIVE To search for possible immunogenetic differencies between the patients with familial and non-familial rheumatoid arthritis (RA). METHODS The study compared 129 familial RA patients with 217 non-familial patients for the frequencies of HLA-DR antigens including DR4 subtypes, DR4-DQB1*0301 and DR4-DQB1*0302 haplotypes and HLA-B27 antigen as well as the age of disease onset and existence of rheumatoid factor or joint erosions. RESULTS Two major differences between familial and non-familial groups were found: firstly, familial RA patients had increased frequency of HLA-DR4 as compared with the non-familial RA group (68.2v 54.8%; p = 0.019). Secondly, the mean age at onset of RA was significantly lower in the familial than in the sporadic RA patients (42.0 v 46.5 years; p = 0.0020) and the difference still remained when the DR4 positive and negative subgroups were compared separately. CONCLUSION These results confirm the more prominent association with HLA-DR4 in familial than in the non-familial cases and suggest that accumulation of HLA risk genes may, at least partly, explain the familial occurrence of the disease. Other susceptibility genes may also be concentrated in multiplex case families as suggested by an earlier age at the onset of RA in both HLA-DR4 positive and negative familial patients.
Mobile Community Support: A Mobile Reservation System For The Leisure Industry

Communities (especially virtual communities) of Interest have recently been the focus of substantial consideration within academic literature. This paper addresses Communities of Interest within the Leisure Industry and provides an innovative value added service concept for mobile coordination support for individuals. Thus it extends the discussion to mobile communities, which in fact leads to a hybrid-solution. After briefly presenting the state of the art of IT in the leisure industry and describing the empirical aspect of the project objectives we introduce the MCOR (Mobile Community Online Reservation) system. Finally we discuss design considerations and the blueprint of our future research.
Learning Effect of Short-wavelength Automated Perimetry in Patients With Ocular Hypertension

AimTo evaluate the learning effect of short-wavelength automated perimetry (SWAP) on a group of patients with ocular hypertension experienced with standard automated perimetry (SAP). MethodsThirty patients with ocular hypertension underwent 5 full-threshold SWAP tests at intervals of 7±2 days. The parameters investigated to detect a learning effect were duration, the perimetric indices, and the number of points with a P of <5% and 1% in the total and pattern deviation maps. Differences in learning effect were also evaluated by comparing the sensitivities of central, paracentral, and peripheral areas, hemifields and quadrants. ResultsLearning effects were demonstrated for mean defect (P<0.0001, analysis of variance), duration (P=0.0001), the number of points with P<5% in the pattern deviation map (P=0.003), and short fluctuations (P=0.03). The effect was greater in the peripheral than in central areas (P=0.04). Mean defect was the most sensitive parameter, for which the learning effect was statistically significant between the first and the fifth test. ConclusionsThe results of this study demonstrate a significant learning effect at full-threshold SWAP. This may limit the efficacy of this kind of perimetry in detecting early glaucoma, and should therefore be carefully considered when creating normative databases for new SWAP strategies.
Impact of Trapping Effects on the Recovery Time of GaN Based Low Noise Amplifiers

This study investigates recovery time of the gain of AlGaN/GaN HEMT based low noise amplifiers (LNA) after an input overdrive pulse. Three LNAs, fabricated in two commercial MMIC processes and a Chalmers in-house process, are evaluated. The Chalmers process has an unintentionally doped buffer instead of the intentional Fe doping of the buffer which is standard in commercial GaN HEMT technologies. It is shown that the LNAs from the two commercial processes experience a severe drop in gain after input overdrive pulses higher than 28 dBm, recovering over a duration of around 20 ms. In contrast the LNA fabricated in-house at Chalmers experienced no visible effects up to an input power of 33 dBm. These results have impact for radar and electronic warfare receivers, which need to be operational immediately after an overdrive pulse. The long time constants suggest that these effects are due to trapping in the transistors with the Fe doped buffer playing an important role.
Do Economic Institutions Matter for Growth Episodes?

An increasingly large literature on the empirics of economic growth has viewed it as an ‘episodic phenomenon’. In this paper, we re-evaluate the relationship between growth and economic institutions using an episodic framework, where the relevant units of empirical analysis are growth episodes. We use episodes identified in Kar et al. (2013) and quantify their success using a novel 'measure' termed as 'episode magnitude', adopted from Pritchett et al. (2016). In order to capture the multi-functionality of economic institutions, we use separate measures for property rights institutions, contractual institutions and state capacity. Using instrumental variable methods, we show that, together with human capital and level of development, higher institutional quality is also a significant factor that determines more successful growth episodes.
The apical ligament: anatomy and functional significance.

OBJECT The authors conducted a study to describe the detailed anatomy of the apical ligament and to acknowledge or refute its historical description as a functionally significant contributor to craniocervical stability. METHODS In 20 adult human cadavers measurements of the apical ligament were obtained, and its detailed anatomy was observed. Ranges of motion were also assessed to discern the function of the apical ligament. CONCLUSIONS Results of the study support the concept that the apical ligament is best described as a vestigial structure that offers no significant added stability to the craniocervical junction. In fact, this ligament was absent in 20% of the specimens examined. These data will aid physicians who frequently view images or manage clinical problems of the craniocervical junction because they may focus on other ligaments of this area and not the apical ligament.
Relation of Angiographic Thrombus Burden With Electrocardiographic Grade III Ischemia in Patients With ST-Segment Elevation Myocardial Infarction

Background: We aimed to investigate the association between electrocardiographic (ECG) grade III ischemia and angiographic thrombus burden in patients with acute ST-segment elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (pPCI). Methods: The study population consisted of 307 patients with STEMI. Baseline ECGs of the patients were analyzed for grade III ischemia; angiographic thrombus burden was assessed by thrombolysis in myocardial infarction thrombus classification. Results: A total of 108 (35%) patients had low thrombus burden whereas 199 (65%) patients had high thrombus burden. Grade III ischemia was more prevalent in patients with high thrombus burden (25.1% vs 11.1%, P = .004). Only grade III ischemia (odds ratio: 2.59, 95% confidence interval 1.24-5.39, P = .011) and history of coronary artery disease (CAD) were found to be the independent predictors of high thrombus burden. Conclusion: Grade III ischemia on ECG and previous history of CAD were independent predictors of coronary thrombus burden in patients with STEMI who underwent pPCI.
BORSA İSTANBUL KURUMSAL YÖNETİM ENDEKSİ (XKURY) İLE KORKU ENDEKSİ (CHICAGO BOARD OPTIONS EXCHANGE VOLATILITY INDEX-VIX) ARASINDAKİ İLİŞKİNİN ANALİZİ

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Avalanche Multiplication in InAlAs

A systematic study of avalanche multiplication on a series of In 0.52Al0. 48As p+-i-n+ and n +-i-p+ diodes with nominal intrinsic region thicknesses ranging from 0.1 to 2.5 mum has been used to deduce effective ionization coefficients between 220 and 980 kVmiddotcm-1. The electron and hole ionization coefficient ratio varies from 32.6 to 1.2 with increasing field. Tunneling begins to dominate the bulk current prior to avalanche breakdown in the 0.1-mum-thick structure, imposing an upper limit to the operating field. While the local model can accurately predict the breakdown in the diodes, multiplication is overestimated at low fields. The effects of ionization dead space, which becomes more significant as the intrinsic region thickness reduces, can be corrected for by using a simple correction technique
Novel Application of Proton Pump Inhibitor for the Prevention of Colitis-Induced Colorectal Carcinogenesis beyond Acid Suppression

Colitis-associated cancers arise in the setting of chronic inflammation wherein an “inflammation-dysplasia-carcinoma” sequence prevails. Based on our previous findings in which the proton pump inhibitor could impose significant levels of anti-inflammatory, antiangiogenic, and selective apoptosis induction beyond gastric acid suppression, we investigated whether omeprazole could prevent the development of colitis-associated cancer in a mouse model induced by repeated bouts of colitis. Omeprazole, 10 mg/kg, was given i.p. all through the experimental periods for colitis-associated carcinogenesis. Molecular changes regarding inflammation and carcinogenesis were compared between control groups and colitis-associated cancer groups treated with omeprazole in addition to chemopreventive outcome. Nine of 12 (75.0%) mice in the control group developed multiple colorectal tumors, whereas tumors were noted in only 3 of 12 (25.0%) mice treated with daily injections of omeprazole. The cancer-preventive results of omeprazole treatment was based on significant decreases in the levels of nitric oxide, thiobarbituric acid–reactive substance, and interleukin-6 accompanied with attenuated expressions of tumor necrosis factor-α, inducible nitric oxide synthase, and cyclooxygenase-2. The expressions of matrix metalloproteinase (MMP)-9, MMP-11, and MT1-MMMP were significantly decreased in mice treated with omeprazole in accordance with significant decreases in the number of β-catenin–accumulated crypts. A significant induction of apoptosis was observed in tumor tissue treated with omeprazole. Omeprazole could block the trophic effect of gastrin in colon epithelial cells. The significant anti-inflammatory, antioxidative, and antimutagenic activities of omeprazole played a cancer-preventive role against colitis-induced carcinogenesis, and our novel in vivo evidence is suggestive of chemopreventive action independent of gastric acid suppression. Cancer Prev Res; 3(8); 963–74. ©2010 AACR.
Transoral robotic surgery and human papillomavirus status: Oncologic results

Patients with oropharyngeal squamous cell carcinoma (OPSCC) have been shown to have distinct outcome profiles based on their human papillomavirus (HPV) status. The purpose of this study was to assess HPV‐related outcomes after transoral robotic surgery (TORS) with adjuvant therapy as indicated.