Miracle-dz/UniFAR-FTUs huggingface dataset:
Phytochemical characterisation for industrial use of pomegranate (Punica granatum L.) cultivars grown in Spain.

BACKGROUND The study of 15 pomegranate cultivars was carried out in order to demonstrate the wide diversity among the quality of Spanish pomegranates, and compared to 'Wonderful' cultivars, which are used worldwide for industrial purposes. Juice yield, quality parameters, organic acids and sugars, colour, vitamin C, ellagic acid, punicalagins, anthocyanins, total phenolic content, antioxidant capacity, and sensory properties were measured. RESULTS A considerable variation was found between 'Wonderful' and pomegranates of Spanish origin, according to both cluster analysis and principal component analysis. 'Wonderful' juices displayed large antioxidant activity and a polyphenol content with very high acidity. In contrast, 'Mollar de Elche' showed fewer anthocyanins although it had very superior organoleptical properties. In addition to a high content in ellagitannins, 'Valenciana' juices had exclusive colour parameters. CONCLUSION These useful results can be employed by the juice processing industry to select those properties more interesting for the development of pomegranate juices that are organoleptically attractive and rich in bioactive compounds.
Effect of age and route of inoculation on outcome of neonatal herpes simplex virus infection in guinea pigs

The morbidity and mortality of neonatal herpes simplex virus infection remains unacceptably high despite antiviral therapy. A better understanding of factors that might contribute to this poor outcome is needed but has been hindered by a lack of a good animal model. The recently described guinea pig model of neonatal HSV‐2 infection was used to explore the effect of age and route of inoculation on the outcome of infection. After intranasal inoculation the onset, extent, and severity of the primary disease, as well as the number of recurrent lesion days, varied inversely with age. The route of inoculation also affected the outcome. Newborn animals were inoculated either intradermally on the scalp or by the intranasal, oral or corneal route. Animals inoculated on the scalp had the best outcome with no deaths or evidence of neurologic disease while the intranasal route produced the most severe disease, 88% mortality. Neurologic disease was common after oral (41%) and corneal (56%) inoculation but resolved spontaneously whereas following intranasal (39%) inoculation all animals with neurologic disease died. Recurrent disease manifest by cutaneous lesions was observed in all survivors of each group but also differed by the route of inoculation. The guinea pig model of neonatal HSV‐2 disease appears to mimic human disease. The studies presented here show that the outcome of infection is influenced by the age and route of inoculation. © 1996 Wiley‐Liss, Inc.
Green chicken purchase behavior: the moderating role of price transparency

Purpose Developing green consumption, organic and green meat and poultry consumption have been increased recently. The purpose of this paper is to investigate the effect of food’s sensory characteristics (e.g. organic food beliefs) and non-food factors (e.g. price transparency) on consumers’ green purchase behavior. So, according to the moderating role of price transparency, affecting factors on green chicken purchase intention and behavior are examined. Design/methodology/approach Evaluating the model, the authors used measures from previous research. The authors distributed questionnaire in four chain stores in four different geographical regions in Tehran. The structural model and relations were examined by using Smart PLS 2.0 software to simultaneously estimate the measurement and structural models. Findings Structural equation analysis revealed that level of trust, consumer’s organic food beliefs and perceived environmental responsibility have positive impact on green purchase intention. Also price transparency moderator role confirmed that moderators can affect consumers’ actual behavior. Research limitations/implications As our sample was just from Tehran, the research results may lack generalizability to all people in Iran. Therefore, future researchers are encouraged to retest the proposed model in other cities and also in other countries with different level of economic development. Practical implications This paper includes suggestions for managers and producers to develop green food products consumption especially green chicken. Also it has implications for spreading out green consumption among people with high environmental involvement. Originality/value Despite conducted research, the moderating role of price transparency has been used only rarely to investigate consumers’ green purchase behavior.
Professional Identity Development of International Counselor Education Doctoral Students

ABSTRACT The current study examined perceptions of professional identity among international counselor education (CE) doctoral students. A Consensual Qualitative Research (CQR) design was used to explore the experiences of 13 international CE doctoral students. All participants had a clear understanding of the emerging nature of their professional identities, cited the impact of engaging in professional development opportunities, and described the importance of faculty relationships to their professional identity development. Many participants also described how their values resonated with the CE field and perceived other support systems (e.g., peer, family, community) as important to their professional identities. Implications and recommendations are discussed.
Effect of lymphatic mapping on the new tumor-node-metastasis classification for colorectal cancer.

PURPOSE Sensitive detection methods and accurate reporting are necessary to determine the prognostic significance of micrometastases (MM) and isolated tumor cells (ITCs) in lymph nodes that drain colorectal cancers (CRCs). This study examined the role of lymphatic mapping (LM) in the application of the new tumor-node-metastasis (TNM) classification for MM and ITC. PATIENTS AND METHODS All patients at the John Wayne Cancer Institute underwent LM immediately before standard resection of primary CRC between 1996 and 2001. Sentinel nodes (SNs) were identified using blue dye and/or radiotracer and were examined by hematoxylin-eosin (H&E) staining, cytokeratin immunohistochemistry, and multilevel sectioning. The comparison group comprised 370 patients whose primary CRCs were resected without LM during the same period at the same institution. RESULTS LM was successfully performed in 115 of 120 (96%) patients and correctly predicted the tumor status of the nodal basin in 110 of 115 (96%) patients. Thirty-seven patients (32%) were lymph node-positive by H&E, ITC and MM were found in 23 patients (29.4%) whose lymph nodes were negative by H&E. Tumor deposits were found in the SN only in 29 patients (50%). Nodal involvement was identified for 14.3%, 30%, 74.6%, and 83.3% of T1, T2, T3, and T4 tumors, respectively, in the study group, and for 6.8%, 8.5%, 49.3%, and 41.8% of T1, T2, T3, and T4 tumors, respectively, in the comparison group. The study group had a higher percentage of nodal metastases (53% v 36%; P <.01) and a higher incidence of MM and ITC (29.4% v 1.9%; P <.0001). The mean number of lymph nodes found in the study group (14) was also significantly more than the number found in the comparison group (10; P <.00001). CONCLUSION Conventional examination of lymph nodes for CRC is inadequate for the detection of MM and ITC as described in the new TNM classification. Thus, LM and focused SN analysis should be considered to fully stage CRC.
The Development of an Online Clinical Log for Advanced Practice Nursing Students: A Case Study

Three years ago at the Medinfo conference a prototype version of a clinical log for nursing students at Vanderbilt University was demonstrated. The purpose of the log is to document the types of clinical experiences the students are participating in as part of their academic program. We collected log data during that first year and received ongoing formative feedback from both students and faculty regarding its current feature set and desirable features for future implementations. Most of the requested new features have now been implemented. This paper describes some of the latest features of the clinical log, the advantages and disadvantages of ongoing development versus acquiring commercial products, and the procedures and results we have put in place to gather from faculty and students the features they want to see in the log. This paper also documents some of the data from early data mining.
Opportunistic Periodic Feedback Mechanisms for OFDMA Systems under Feedback Budget Constraint

Adaptive modulation and coding scheme is commonly used in mobile and wireless systems to achieve high-data rates and increase system efficiency. Such adaptation invariably requires some channel information to be fed back to the base station and leads to a non negligible increase in uplink overhead. To deal with this issue, adequate feedback reduction mechanisms are mandatory especially in multiuser multicarrier systems such as OFDMA. Periodic feedback mechanisms have been proposed to significantly reduce feedback information when many users need to be scheduled in each transmission frame with constraint feedback budget. In this paper, we propose an opportunistic periodic feedback approach which exploits the hints from MAC ARQ protocol to enhance the performance of periodic feedback mechanisms. Simulation results show that our opportunistic strategy improves the performance in terms of throughput, bit error rate and MAC frame lossrate especially for high mobility scenarios.
Alpha‐Galactosidase A Activity Levels in Turkish Male Hemodialysis Patients

Fabry disease is an X‐linked lysosomal storage disorder due to deficient activity of alpha‐galactosidase A (α‐Gal A) leading to renal insufficiency in males. The aim of present study was to investigate the level of α‐Gal A activity and to determine the prevalence of Fabry disease in a Turkish male hemodialysis population. The activity of plasma α‐Gal A was measured in a group of 808 male hemodialysis patients using fluorimetric methods. Patients with low α‐Gal A activity were evaluated clinically and genetic testing was carried out. A correlation with creatinine, uric acid, urea, white blood cell (WBC), and high sensitivity (hs)CRP and α‐Gal A activity was also investigated. Plasma α‐Gal A activity among this male population undergoing hemodialysis was 7.88 ± 5.18 µM/hour/L (0.40–55.72), significantly lower when compared to controls. No influence of creatinine, uric acid, WBC, or hsCRP on measured α‐Gal A activity was reported. Two new Fabry disease patients were identified. Both were previously diagnosed with diabetes mellitus type 2. These findings provide, for the first time, data regarding the prevalence of α‐Gal A deficiency (0.24%) in Turkish males receiving hemodialysis.
Emerging Updates on the Posterior Cruciate Ligament

The posterior cruciate ligament (PCL) is recognized as an essential stabilizer of the knee. However, the complexity of the ligament has generated controversy about its definitive role and the recommended treatment after injury. A proper understanding of the functional role of the PCL is necessary to minimize residual instability, osteoarthritic progression, and failure of additional concomitant ligament graft reconstructions or meniscal repairs after treatment. Recent anatomic and biomechanical studies have elucidated the surgically relevant quantitative anatomy and confirmed the codominant role of the anterolateral and posteromedial bundles of the PCL. Although nonoperative treatment has historically been the initial treatment of choice for isolated PCL injury, possibly biased by the historically poorer objective outcomes postoperatively compared with anterior cruciate ligament reconstructions, surgical intervention has been increasingly used for isolated and combined PCL injuries. Recent studies have more clearly elucidated the biomechanical and clinical effects after PCL tears and resultant treatments. This article presents a thorough review of updates on the clinically relevant anatomy, epidemiology, biomechanical function, diagnosis, and current treatments for the PCL, with an emphasis on the emerging clinical and biomechanical evidence regarding each of the treatment choices for PCL reconstruction surgery. It is recommended that future outcomes studies use PCL stress radiographs to determine objective outcomes and that evidence level 1 and 2 studies be performed to assess outcomes between transtibial and tibial inlay reconstructions and also between single- and double-bundle PCL reconstructions.
Ectopic Expression of Apple F3′H Genes Contributes to Anthocyanin Accumulation in the Arabidopsis tt7 Mutant Grown Under Nitrogen Stress1[C][W][OA]

Three genes encoding flavonoid 3′-hydroxylase (F3′H) in apple (Malus × domestica), designated MdF3′HI, MdF3′HIIa, and MdF3′HIIb, have been identified. MdF3′HIIa and MdF3′HIIb are almost identical in amino acid sequences, and they are allelic, whereas MdF3′HI has 91% nucleotide sequence identity in the coding region to both MdF3′HIIa and MdF3′HIIb. MdF3′HI and MdF3′HII genes are mapped onto linkage groups 14 and 6, respectively, of the apple genome. Throughout the development of apple fruit, transcriptional levels of MdF3′H genes along with other anthocyanin biosynthesis genes are higher in the red-skinned cv Red Delicious than that in the yellow-skinned cv Golden Delicious. Moreover, patterns of MdF3′H gene expression correspond to accumulation patterns of flavonoids in apple fruit. These findings suggest that MdF3′H genes are coordinately expressed with other genes in the anthocyanin biosynthetic pathway in apple. The functionality of these apple F3′H genes has been demonstrated via their ectopic expression in both the Arabidopsis (Arabidopsis thaliana) transparent testa7-1 (tt7) mutant and tobacco (Nicotiana tabacum). When grown under nitrogen-deficient conditions, transgenic Arabidopsis tt7 seedlings expressing apple F3′H regained red color pigmentation and significantly accumulated both 4′-hydrylated pelargonidin and 3′,4′-hydrylated cyanidin. When compared with wild-type plants, flowers of transgenic tobacco lines overexpressing apple F3′H genes exhibited enhanced red color pigmentation. This suggests that the F3′H enzyme may coordinately interact with other flavonoid enzymes in the anthocyanin biosynthesis pathway.
Determinants of Web-based disclosure in the Middle East

Purpose This paper aims to examine the factors influencing the extent of information disclosed on the companies’ websites in the Middle East region. Design/methodology/approach This study uses multiple regression models to examine the impact of some companies’ characteristics (company size, leverage, profitability, size of the audit firm, ownership concentration) on the extent of online disclosure. The study was conducted on 170 listed companies in seven countries (Saudi Arabia, Bahrain, the UAE, Jordan, Kuwait, Qatar and Turkey). The website content was analyzed during the period from September 2015 to December 2015. Findings The results reveal that the most important factors influencing the level of Web-based disclosure are company size, leverage and the size of the audit firm. Practical implications The results of the study will help regulators to formulate policies about Web-based disclosure as they offer insights into the characteristics of those companies which do and do not meet investors’ demands for online information. Thereby, the regulators might expect that the Middle East companies engage in the online reporting to be larger, have higher debt levels and audited by a big-four audit firm. Originality/value This study, added to the existing literature by analyzing seven countries in the Middle East region, allows having a clearer idea on the online disclosure in this region as a whole, which has not been examined before. In this paper, to assess the information’s disclosure on the website, the study has been interested in all of the information presented on the websites: financial and non-financial information.
Plasma levels of thyroxine and triiodothyronine in women with breast cancer.

24-hour mean plasma levels of T3 and T4 were compared in 29 rigorously selected breast cancer patients (all stages) and 27 healthy women, and 8 A.M. "spot" plasma T4 levels were compared in 43 consecutive unselected breast cancer patients (all stages), 22 women with other-than-breast cancer, 21 women with miscellaneous non-cancerous illnesses, and the same 27 healthy women. The 24-hour T3 levels were the same in the breast cancer patients and healthy controls, but the 24-hour T4 levels were significantly higher in the cancer patients (7.7 vs 5.8 micrograms/dl, p less than 0.001); equal elevations were present in all stages of cancer. Spot T4 levels were likewise significantly higher in the breast cancer patients than in the healthy controls (8.8 vs 7.3 micrograms/dl, p less than 0.005). The women with other-than-breast cancer and the women with miscellaneous non-cancerous illnesses also showed significant elevations of spot T4 levels, indistinguishable from those of the breast cancer patients. It is concluded that breast cancer patients as a group show significant hyperthyroxinemia and that this finding may represent a second nonspecific abnormality of thyroid hormones in disease, hypotriiodothyroninemia (low-T3 syndrome) being the first.
Decreased Production of Local Immunoglobulin A toPneumocystis carinii in Bronchoalveolar Lavage Fluid from Human Immunodeficiency Virus-Positive Patients

ABSTRACT An enzyme-linked immunosorbent assay and a Western blot analysis were developed to study the antibody response to Pneumocystis carinii in serum and bronchoalveolar lavage fluid from 27 human immunodeficiency virus 27 (HIV)-infected patients with P. carinii pneumonia (Pcp), 32 patients without Pcp, and 51 HIV-negative controls. Urea was used for the correct dilution of epithelial lining fluid, and albumin was used to evaluate transudation from plasma for the assessment of local production of antibodies toP. carinii. By contrast with those of immunoglobulin G (IgG), IgA responses to P. carinii were increased in serum from HIV-positive patients compared to negative controls. Local production of antibodies to P. carinii, especially IgA, was decreased in patients with Pcp. In a study of 10 patients of each group, IgG and IgA responses to gp116 from P. carinii were lower in patients with Pcp than in other groups. These results suggest that, in addition to alveolar macrophages, local antibodies may play a role in host defense against P. carinii.
HlyX, the FNR homologue of Actinobacillus pleuropneumoniae, is a [4Fe–4S]‐containing oxygen‐responsive transcription regulator that anaerobically activates FNR‐dependent Class I promoters via an enhanced AR1 contact

The hlyX gene of the pig pathogen Actinobacillus pleuropneumoniae encodes HlyX, a homologue of FNR, the anaerobic transcription regulator of Escherichia coli. The hlyX gene complements the anaerobic respiratory deficiencies of E. coli fnr mutants but also induces the expression of an otherwise latent haemolysin. Therefore, FNR and HlyX have distinct but overlapping regulons. The hlyX gene has been overexpressed as a gst ::hlyX fusion and the HlyX protein purified. Similar to FNR, HlyX can acquire a [4Fe–4S] cluster, which promotes binding to the FNR box (Kd of 20–30 nM) under anaerobic conditions. Expression of hlyX in E. coli induced the anaerobic production of at least five polypeptides, including the yfiD gene product, which were not induced by fnr. Analysis of the yfiD promoter region revealed the presence of two FNR boxes situated at −61.5 and −114.5. Consistent with this observation, expression from the semi‐synthetic Class I promoter FF+20pmelR was efficiently activated by HlyX but not by FNR. The weaker level of FNR‐mediated activation of Class I promoters suggests that there is a poorer activating contact (activating region 1 (AR1) equivalent) between FNR and RNA polymerase at these promoters and that HlyX possesses an additional or improved AR1. The AR1 of HlyX is partially characterized by a surface‐exposed region around amino acid A187, which confers the altered specificity and provides an explanation for the existence of distinct but overlapping HlyX and FNR regulons.
What makes you work while you are sick? Evidence from a survey of workers.

BACKGROUND Sickness absenteeism has been a focus of the EU Labour Force Surveys since the early 1970s. In contrast, sickness presenteeism is a newcomer. Based on surveys, this concept emerged in the empirical literature as late as the 1990s. Knowledge of the determinants of sickness presenteeism is still relatively sparse. METHODS The article examines the prevalence of sickness presenteeism in comparison with sickness absenteeism, using survey data covering 725 Finnish union members in 2008. We estimate logit models. The predictor variables capture working-time arrangements and the rules at the workplace. We include control variables such as the sector of the economy and educational attainment. RESULTS Controlling for worker characteristics, we find that sickness presenteeism is much more sensitive to working-time arrangements than sickness absenteeism is. Permanent full-time work, mismatch between desired and actual working hours, shift or period work and overlong working weeks increase sickness presenteeism. We also find an interesting trade-off between sickness categories: regular overtime decreases sickness absenteeism, but increases sickness presenteeism. CONCLUSIONS Two work-related sickness categories, absenteeism and presenteeism, are counterparts. However, the explanations for their prevalence point to different factors.
What is Driving Inflation and GDP in a Small European Economy: The Case of Croatia

In this paper we estimate and identify a small open economy Bayesian VAR model in order to disentangle the contribution of individual domestic, euro area-specific and global shocks to domestic macroeconomic developments. Our identification suggests that foreign (global and euro area - specific) shocks have a large impact on the variability of domestic variables - they account for approximately 40% of variation in GDP growth and around 50% of variation in inflation. Looking at the contribution of individual structural shocks our results emphasize two particular findings. First, low oil prices have played an important role for muted inflation in Croatia during the last two years while, at the same time, domestic real activity has not benefited much. We show how this finding depends crucially on the specific mix of economic shocks underlying the movements in oil prices (demand vs supply shocks). Second, our results suggest that the large-scale asset purchase programme launched by the ECB at the beginning of 2015 resulted in favourable, albeit limited, spillover effects on domestic economy.