Miracle-dz/UniFAR-FTUs huggingface dataset:
Localization of AMPA-selective glutamate receptor subunits in the adult cat visual cortex

Abstract We have studied the presence and distribution of α-amino-3–hydroxy-5–methyl-4–isoxazolepropionate (AMPA)-selective glutamate receptor subunits (GluR 1, 2, 3, and 4) in the adult cat visual cortical areas 17, 18, 19, and the lateral suprasylvian areas (LSA). Reverse transcription-polymerase chain reaction (RT-PCR) amplification indicated that the genes encoding GluR 1, 2, 3, and 4 are expressed in these areas and Western blot analysis revealed that the size of the corresponding peptides is similar to those described in the rat brain. In situ hybridization (ISH) using digoxigenin-labeled riboprobes showed that mRNAs coding for GluR1 and GluR3 were located in cells in all layers of the areas examined and also in the underlying white matter. GluR1 mRNA was relatively abundant throughout layers II–VI while GluR3 mRNA revealed a more laminated pattern of expression, preferentially labeling cells in layers II, III, V, and VI. The distribution of AMPA-selective receptor subunit peptides was studied by immunohistochemistry using subunit specific antibodies and found to be consistent with ISH results. In addition, we observed that most of the cells strongly labeled by the anti-GluR1 antibody were non-pyramidal neurons and that intense GluR2/3 immunoreactivity was seen preferentially in pyramidal neurons. Interestingly, double-labeling experiments indicated that neurons expressing γ-aminobutyric acid (GABA) as well as the GluR1 subunit were particularly abundant in deeper layers. The GluR4 peptide was predominantly found in a relatively low number of layer III and layer V neurons with either pyramidal or non-pyramidal morphology. Finally, the distribution of neurons expressing the various receptor subunits was similar in all the visual cortical areas studied. These findings indicate a high expression of GluR1–3 subunits in the cat visual cortex and that GluR1 and GluR2/3 subunits are particularly abundant in non-pyramidal and pyramidal neurons, respectively. In addition, the results described here provide a reference for future studies dealing with the effect of visual deprivation on the expression of this receptor type.
Antibacterial Spectrum of Umckaloabo ( Pelargonium Sidoides ) On Upper Airway Infection Agents

Aim: In this study we aimed to search the antibacterial effect of the drugs with active ingredients of Pelargonium sidoides on different bacterial species isolated from the throat cultures of patients with upper airway infection. Methods: Antibacterial activity on 72 Streptococci, 48 Stapyhlococcus, 32 Neisseriae spp, 20 Moraxella catarrhalis, and 20 Haemophilus influenzae was evaluated by using microdilution broth method. Results: Antibacterial effect was detected on 8 Neisseriae spp, 4 Haemophilus influenzae, 4 Streptococcus pneumoniae, 4 Staphylococcus epidermidis and 4 Moraxella catharralis at 200 microgram and higher concentrations of the drug; but no meaningful antibacterial activity on other kinds of bacteria tested was observed Conclusion: The scientific data with respect to antibacterial effect of Pelargonium sidoides are hopeful, but it is unadvisable to use this drug instead of antibiotic treatments.
Subjective responses to oral tobacco products: scale validation.

INTRODUCTION Several noncombusted oral tobacco products have been introduced that are primarily marketed to cigarette smokers. An important component of evaluating these products involves assessment of subjective responses to the product. To date, few studies have been undertaken to examine the validity of subjective response questionnaires for oral tobacco products. The goal of this study is to examine the extent subjective responses to a product are related to product preference and extent of product use. METHODS Data from a study examining oral tobacco product preference were used. Smokers were asked to sample a variety of oral tobacco products that differed in formulation (snus versus dissolvables) and dose of nicotine. At the end of the sampling period, subjects were asked to choose the product that they would use to completely substitute for cigarettes for the next 2 weeks. During the sampling period, subjects completed a Product Evaluation Scale (PES) that describes subjective responses to the product. During the treatment phase, they kept record of amount of product use. RESULTS Subjective responses to the product on the PES were related to product choice and to some extent, the amount of product use. Product choice was associated with different characteristics of the product and smoker needs. CONCLUSION The PES may be a useful tool for the evaluation or oral tobacco products.
Functional taping: a promising technique for children with cerebral palsy

SIR–Limitations in the motor activity of children with cerebral palsy (CP) are the consequence of a failure to acquire appropriate motor schemas, caused by arrested normal brain maturation. Nevertheless, some of these children, exploiting their few available resources, manage to walk, thanks to the emergence of atypical but still functional locomotor patterns. However, these patterns can lead to long-term instability, contractures, and deformities. Common treatments for children with CP include botulinum toxin, serial casting, orthopaedic surgery, and orthoses. These somewhat invasive interventions are designed to act at the peripheral level, without particularly aiming at promoting more normal motor development at the central level. Functional taping may be a slightly less invasive solution in trying to reach this objective. This technique, commonly used in sports traumatology and lately proposed for patients with stroke, aims at supporting an injured joint, protecting weak structures, and enhancing sensory feedback. This much less invasive intervention could favour the integration of therapy and daily activities and increase participation in social life. Nevertheless, it has been only applied infrequently in these children and only at upper-body level. A pilot study was performed to test the effects of lower limb taping on the locomotor function of a group of children with spastic unilateral CP. These children were already being treated with conventional physical therapy consisting of 1-hour treatment, repeated two times a week and based on neurodevelopmental treatment (derived from the Bobath concept). It included stretching, weak muscle strengthening, and postural and walking training. However, in the months preceding the study, the above therapy alone was judged to be no longer effective for the children because expected improvements in gross motor function were not being achieved. After the approval of the ethical committee of Fondazione Santa Lucia and the informed consent of both parents, eight children (initial mean age of 4y and 8m, SD 3y, all diagnosed with spastic unilateral CP; Table SI, supporting information published online, who were able to walk independently, were
Association of Perioperative Use of Nonsteroidal Anti-Inflammatory Drugs With Postoperative Myocardial Infarction After Total Joint Replacement

Background and Objectives Use of nonsteroidal anti-inflammatory drug (NSAIDs) analgesics is controversial because of cardiovascular risk, but perioperative use may be advantageous for total joint replacement. Thus, we performed this single-center observational cohort study to determine any association between NSAID use and postoperative myocardial infarction (POMI). Methods All patient admissions undergoing total hip or knee replacement between March 3, 2009, and September 1, 2010, were identified. Nonsteroidal anti-inflammatory drug use was identified. Postoperative myocardial infarction was defined as troponin I level greater than 0.1 ng/mL. Propensity scores were calculated to adjust for bias of receiving NSAIDs and troponin measurements. Propensity scores and other covariates were used in logistic regression to determine the independent association of NSAID use with POMI. Results Of the 10,873 arthroplasty admissions, 1518 (14%) had serial troponins measured, and 97 had a POMI (0.9%). Incidence of POMI was 0.8% for the 9,831 who received NSAIDs and 1.8% for the 1,042 (10%) admitted patients who did not receive NSAIDs with a risk difference of −1% with 95% confidence interval (CI) of −0.2% to −1.9%. The adjusted odds ratio (0.95; 95% CI, 0.5–1.8) and relative risk (0.95; 95% CI, 0.5–1.8) indicated that NSAIDs were not significantly associated with the risk of POMI. Mean duration of NSAID use was 3 days. Length of stay (98 versus 115 hours) was significantly reduced in the NSAID group. Conclusions Brief perioperative use of NSAIDs was not associated with increased risk for myocardial infarction after total hip and knee replacement; it may provide benefit in length of stay.
Breast Cancer Treatment During Pregnancy

The diagnosis of breast cancer during pregnancy, athough uncommon, can be a devastating and confusing diagnosis for many women. Many clinicians are unaware of the treatment options available for the pregnant patient and are unable to counsel their patients. The treatment of pregnancy-associated breast cancer is determined by the age of gestation and the stage of cancer at presentation. A multidisciplinary approach involving a medical oncologist, surgical oncologist, radiation oncologist and high-risk obstetrician will lead to an optimal outcome for the mother and child. This article will discuss the management of a pregnant patient with breast cancer.
Dysplasia at the surgical margin is associated with recurrence after resection of non-invasive intraductal papillary mucinous neoplasms.

BACKGROUND The significance of a positive margin in resected non-invasive pancreatic intraductal papillary mucinous neoplasms (IPMN) remains controversial. The aim of this study was to determine recurrence rates when dysplasia was present at the final surgical margin. METHODS A prospectively maintained database identified 192 patients undergoing resection of non-invasive IPMN. Pathological, peri-operative and recurrence data were analysed. RESULTS Ductal dysplasia was identified at the final surgical margin in 86 patients (45%) and defined as IPMN or Pancreatic Intraepithelial Neoplasia PanIN in 38 (20%) and 54 (28%) patients, respectively. At a median follow-up of 46 months, 40 (21%) patients recurred with 31 developing radiographical evidence of new cysts, 6 re-resected for IPMN and 3 diagnosed with pancreatic cancer within the remnant. Of those with margin dysplasia, 31% developed recurrent disease compared with 13% in those without dysplasia (P = 0.002). On multivariate analysis, margin dysplasia was associated with a three-fold increased risk of recurrence (P = 0.02). No relationship between dysplasia and development of pancreatic cancer was found. DISCUSSION In this study, dysplasia at the margin after a pancreatectomy for non-invasive IPMN was associated with recurrence in the remnant gland, but not at the resection margin. While this finding may warrant closer follow-up, it does not identify a gland at higher risk for the subsequent development of invasive disease.
The Organizational Embeddedness of Social Capital: A Comparative Case Study of Two Voluntary Organizations

Abstract Social capital is a popular, but contested concept. It draws attention to the way in which social relations and constructed forms of social organization can produce outcomes on individual and collective levels. However, it is often founded on individualistic, rational-choice models of human behavior that neglect its embeddedness. I explore the embeddedness of social capital through a comparative case study of two voluntary sport organizations in the UK. Through close analysis of in-depth interviews and longitudinal observation, I look at the processes of social capital development and the way socio-organizational context and identity shape these processes.
A critical review of policy on language-in-education for Africa : a case of Zimbabwe

There is overwhelming evidence the world over on the pedagogical benefits of learning in the mother language. Zimbabwe recognized this significant role played by the mother tongue in education when a policy enshrined in the 1987 Education Act was enunciated. The language-in-education policy, which was amended in 2006, allows mother tongue usage up to Grade Seven. Contrary to the stated policy, primary school teachers continue to use English as the medium of instruction in primary schools. The purpose of this study was thus to explore the barriers that rural primary school teachers face in implementing the proposed policy in Masvingo District of Zimbabwe. Literature suggests that factors that inhibit implementation of a mother tongue education policy in excolonial African countries include state-related factors, uninformed language myths and language attitudes which support the dominant role of English. The postcolonial theory paradigm guided this study since the intention was to conduct the research as well as to contribute to how to generate teachers’ participation in mother tongue policy implementation in a postcolonial context. A qualitative case study was employed where semi-structured open ended questionnaires, focus group discussions and individual interviews were used to collect data. Fifteen rural primary school teachers, three school heads and two District Schools Inspectors were purposefully selected to participate in the study. It emerged from the study that all the participants were not knowledgeable about the stipulations of the 2006 language-in-education policy. The major barriers identified include inadequate policy dialogue, unavailability of educational material resources in the mother tongue, language attitudes and individual teacher concerns which contribute to low self-efficacy. A critical analysis of the barriers to implementation success indicates that they are mainly related to postcolonial mentality where language attitudes are deeply entrenched in people’s minds. Participants believed that the challenges they faced could be resolved and they proposed some intervention strategies. The study recommends that teacher education institutions should spearhead the designing of professional development modules that impart knowledge and skills on the implementation of additive bilingual education in primary schools.
Revisiting the Impact of System Use on Task Performance: An Exploitative-Explorative System Use Framework

How information systems impact task performance has attracted a significant amount of attention from information systems researchers and generated high interest among practitioners. A commonly accepted view is that the potential of information systems must be realized through system use. Nevertheless, existing findings regarding the impact of system use on task performance are not yet conclusive. We attributed this to the various conceptualizations of system use and the unclear mechanisms through which system use influences task performance. Thus, this research attempts to create a better understanding of how system use influences task performance. To this end, we developed an exploitative-explorative system use framework in order to reconcile the various conceptualizations of system use and to depict how both exploitative and explorative system use influences task performance through impacting task innovation, management control, and task productivity. We created an instantiation of the framework using USAGE (exploitative system use) and adaptive system use (ASU, explorative system use). We conducted two empirical studies involving two different populations and using two different technologies. The first study consisted of 212 experienced users of MS Office, whereas the second study employed 372 new users of a video-editing tool. Our findings offer insight into how exploitative system use and explorative system use independently and jointly influence task performance constructs and also have implications for research and practices.
Extending dynamic aspect mining with static information

Aspect mining tries to identify crosscutting concerns in legacy systems and thus supports the refactoring into an aspect-oriented design. We briefly introduce DynAMiT, a dynamic aspect mining tool that detects crosscutting concerns based on tracing method executions. While the approach is generally fairly precise, further analysis revealed that some false positives were systematically caused by dynamic binding. Furthermore, some aspect candidates were blurred or not detected due to not-sufficient tracing mechanisms of method executions when using AspectJ's execution pointcuts for the trace generation. We enhanced the mining capabilities of DynAMiT by taking additional static type information into account and generating the traces using call pointcuts instead. In an initial case study with AnChoVis, a 1300 LOC Java program, the number of mined aspect candidates increased by a factor of three, while the number of false positives remained zero.
Changing epidemiology of hepatitis A in the 1990s in Sydney, Australia

Surveillance of hepatitis A in residents of Eastern Sydney Health Area identified substantial epidemics in homosexual males in 1991–2 with a peak rate of 520 per 100000 recorded in males aged 25–29 years, and again in 1995–6, with a peak rate of 405 per 100000 per year in males aged 30–34 years. During 1994–5 an epidemic was detected among disadvantaged youth associated with injecting drug use; peak rates of 200 per 100000 per year were reported in males aged 25–29 years and of 64 per 100000 per year among females aged 20–24 years. The epidemiology of hepatitis A in these inner suburbs of Sydney is characterized by very few childhood cases and recurrent epidemics among homosexual men. Identified risk groups need to be targeted with appropriate messages regarding the importance of hygiene and vaccination in preventing hepatitis A. However, poor access to health services among disadvantaged youth and a constant influx of young homosexual males into these inner suburbs present major challenges to hepatitis A control.
The Effects of CEO Founder Status and Stock Ownership on Entrepreneurial Orientation in Small Firms

This paper studies how governance drives entrepreneurial orientation (EO) in small firms. We argue that founder status and ownership create powerful personal incentives for small firm CEOs to engage in behaviors that influence EO. Integrating stewardship theory and the principal‐principal branch of agency theory, we test our hypotheses on a sample of 339 Swedish firms, and find that CEO founder status is significantly and positively associated with EO, while CEO stock ownership significantly but negatively predicts EO. We additionally test two boundary conditions that show that the founder‐CEO's prior managerial experience in start‐up firms positively moderates the founder‐EO relationship, while contrary to expectations, CEO ownership diversification has no effect on the negative association between ownership and EO. Thus, our study adopts a corporate governance perspective to explain how variations in EO across small firms are driven by the goals and motivations of its leader. Our research also shows that in small, private firms the balance of power is tipped in favor of the CEO rather than the board of directors. Finally, we underline the importance of adopting alternative theoretical lens like stewardship and principal‐principal agency, given that traditional principal‐agent problems are largely mitigated in the small firm context.
The localizing value of the abdominal aura and its evolution

Objective: To evaluate the localizing value of abdominal aura and its evolution into other seizure types. Methods: The seizures of 491 consecutive patients with focal epilepsies were prospectively classified according to a recently introduced semiologic seizure classification. All patients underwent prolonged EEG video monitoring and MRI scan. Two hundred twenty-three patients (45%) had temporal lobe epilepsies (TLE); 113 patients (23%) had extratemporal epilepsies; and for 155 (32%) patients, the epilepsy could not be localized to one lobe. Results: Abdominal auras were more frequent with TLE (117 of 223 patients, 52%) than in extratemporal epilepsy (13 of 113 patients, 12%, p < 0.0001) and more frequent in mesial TLE (70 of 110 patients, 64%) than in neocortical TLE (16 of 41 patients, 39%, p = 0.007). No preponderance to one side existed. Abdominal auras were followed by ictal oral and manual automatisms (automotor seizure) in at least one seizure evolution in all patients with TLE (117 patients, 100%). In contrast, only two patients with extratemporal epilepsy (2 of 13 patients, 15%, p < 0.0001) had abdominal auras evolving into automotor seizures. An abdominal aura is associated with TLE with a probability of 73.6%. The evolution of an abdominal aura into an automotor seizure, however, increases the probability of TLE to 98.3%. Conclusions: These results demonstrate that evolution of abdominal aura into automotor seizure permits differentiation between temporal lobe epilepsy and extratemporal epilepsy, showing that analysis of seizure evolution provides more localizing information than does the frequency of particular seizure types.
Subinteger Range-Bin Alignment Method for ISAR Imaging of Noncooperative Targets

Inverse Synthetic Aperture Radar (ISAR) is a coherent radar technique capable of generating images of noncooperative targets. ISAR may have better performance in adverse meteorological conditions than traditional imaging sensors. Unfortunately, ISAR images are usually blurred because of the relative motion between radar and target. To improve the quality of ISAR products, motion compensation is necessary. In this context, range-bin alignment is the first step for translational motion compensation. In this paper, we propose a subinteger range-bin alignment method based on envelope correlation and reference profiles. The technique, which makes use of a carefully designed optimization stage, is robust against noise, clutter, target scintillation, and error accumulation. It provides us with very fine translational motion compensation. Comparisons with state-of-the-art range-bin alignment methods are included and advantages of the proposal are highlighted. Simulated and live data from a high-resolution linear-frequency-modulated continuous-wave radar are included to perform the pertinent comparisons.
Fas is expressed in human atherosclerotic intima and promotes apoptosis of cytokine-primed human vascular smooth muscle cells.

The membrane protein Fas/Apo-1/CD95 signals programmed cell death or apoptosis in activated T lymphocytes. Vascular smooth muscle cells (SMCs) bear markers of programmed cell death or apoptosis in advanced atherosclerotic plaques that contain immune cells e.g., macrophages and T lymphocytes. This study tested the hypothesis that the Fas death-signaling pathway contributes to apoptosis of SMCs exposed to proinflammatory cytokines produced by these immune cells during atherogenesis. All atherosclerotic plaques examined (n = 14) contained immunoreactive Fas. The majority of the Fas+ SMCs localized in the intima of the plaques, whereas the medial SMCs expressed Fas antigen less prominently. Double staining for DNA fragments (TUNEL) and Fas or cell identification markers colocalized Fas with TUNEL+ SMCs in the areas that contained CD3+ T cells and CD68+ macrophages, suggesting a role for Fas in the induction of SMC apoptosis by activated T cells during atherogenesis. In culture, stimulation with interferon-gamma, tumor necrosis factor-alpha, and interleukin-1 beta increased expression of Fas in SMCs. Incubation with an activating anti-Fas antibody triggered apoptosis of the cytokine-primed but not the untreated SMCs, as demonstrated by TUNEL and electrophoresis of oligonucleosomal DNA fragments. These data suggest that activation of the Fas death-signaling pathway contributes to the induction of SMC apoptosis during atherogenesis and furnish a mechanism whereby immune cells and their cytokines promote this cell death process related to vascular remodeling and plaque rupture.