Miracle-dz/UniFAR-FTUs huggingface dataset:
QRS voltages are transiently increased at the superacute stage of experimental myocarditis.

BACKGROUND There are few reports on the precise electrocardiographic characteristics of acute myocarditis. The present study was focused on QRS voltage changes at the superacute stage of murine myocarditis. METHODS Serial electrocardiograms were recorded during the acute stage of viral myocarditis in mice, and then the cardiac pathology was examined. After recording baseline electrocardiograms, mice (n=235) were inoculated intraperitoneally with the encephalomyocarditis virus, resulting in severe myocarditis. Electrocardiograms were serially recorded until nine days after virus inoculation (superacute stage, days 3 to 6; acute stage, days 7 to 9). Changes in heart rate and QRS voltages were analyzed. RESULTS Serial electrocardiograms revealed that heart rates began to increase after day 3, and that the sum of the QRS voltages increased on day 3 and then decreased on days 7 to 9. Trivial mononuclear cell infiltrations and interstitial edema were most frequently found in mice at the superacute stage. CONCLUSIONS Transient increase of the QRS voltages at the superacute stage of myocarditis was demonstrated, which may be due to an increase in ventricular mass caused by interstitial edema at this stage.
Adult Human Mesenchymal Stem Cell Differentiation to the Osteogenic or Adipogenic Lineage Is Regulated by Mitogen-activated Protein Kinase*

Adult human mesenchymal stem cells are primary, multipotent cells capable of differentiating to osteocytic, chondrocytic, and adipocytic lineages when stimulated under appropriate conditions. To characterize the molecular mechanisms that regulate osteogenic differentiation, we examined the contribution of mitogen-activated protein kinase family members, ERK, JNK, and p38. Treatment of these stem cells with osteogenic supplements resulted in a sustained phase of ERK activation from day 7 to day 11 that coincided with differentiation, before decreasing to basal levels. Activation of JNK occurred much later (day 13 to day 17) in the osteogenic differentiation process. This JNK activation was associated with extracellular matrix synthesis and increased calcium deposition, the two hallmarks of bone formation. Inhibition of ERK activation by PD98059, a specific inhibitor of the ERK signaling pathway, blocked the osteogenic differentiation in a dose-dependent manner, as did transfection with a dominant negative form of MAP kinase kinase (MEK-1). Significantly, the blockage of osteogenic differentiation resulted in the adipogenic differentiation of the stem cells and the expression of adipose-specific mRNAs peroxisome proliferator-activated receptor γ2, aP2, and lipoprotein lipase. These observations provide a potential mechanism involving MAP kinase activation in osteogenic differentiation of adult stem cells and suggest that commitment of hMSCs into osteogenic or adipogenic lineages is governed by activation or inhibition of ERK, respectively.
Geography and the Future of Stock Exchanges: Between Real and Virtual Space

This paper aims to contribute to the debate on the future of stock exchanges and financial centres by focusing on two questions. First, whether, how, why, and which stock exchange activities are prone to concentration in financial centres? Second, are they prone to concentration in national or international financial centres? Through a detail-rich analysis of stock exchange activities, including trading system, as well as relationships with members, issuers, and investors, the paper suggests a framework for the geography of stock exchange activities based on two dimensions-proneness to concentration in a financial centre and proneness to international consolidation. With this framework, predictions are made about the future geography of stock exchange activities led by the argument that while significant geographical reconfigurations are likely to unfold, driven primarily by the development of international networks of stock market institutions, stock exchanges, and financial centres will remain crucially important for each other. Copyright 2007 Blackwell Publishing.
Technology licensing and innovation performance: evidence from Chinese latecomers in high-tech industries

As a catalyst for endogenous technological change, inward technology licensing (ITL) can improve a firm’s innovation performance. This paper investigates the effect of learning by licensing and choice of licensed-in technologies on innovation performance. We extend the ITL strategy to the latecomer context, addressing two critical factors: (1) number of licenses and (2) age of licensed-in technology. We hypothesize about the relationship of the licensee’s innovation performance with the number of licenses and age of licensed-in technology, as well as the moderating effect of the licensee’s absorptive capacity. Based on a sample of 154 Chinese high-tech firms, empirical evidence is found in support of our arguments. This study is the first to consider the significance of the age of licensed-in technology to innovation performance and found that the number of licenses has a curvilinear (an inverted U) relationship with innovation performance. We also confirmed the significant moderating effect of absorptive capacity on the above two relationships.
Adapting to climate change: perceptions of vulnerability of down-hill ski area operators in Southern and Middle Finland

Climate change is likely to affect the tourism sector, particularly areas, such as snow-based tourism, that are directly dependent on climate and weather conditions. Especially vulnerable are low-lying ski areas. This study identifies the climatic factors that are crucial for economically successful operation of low-lying ski areas in Southern and Middle Finland and contemplates how these factors are seen to change with climate change. The study then analyses the preferences for and perceptions of adaptation strategies of downhill ski operators in terms of the adaptation measures they can implement or are willing to take. The findings indicate that climatic conditions set preconditions for the operation of the ski areas, but short-term operational prospects and inter-annual variability in weather conditions rather than foreseen changes in climatic conditions guide the operational decisions of the ski area operators. A key adaptation strategy to respond to uncertain snow conditions is artificial snowmaking, which lowers the vulnerability of the areas to the impacts of climate change too.
Is financial development pro-poor or pro-rich? Empirical evidence from Tanzania

This paper examines the dynamic causal relationship between financial development and poverty reduction in Tanzania. The study attempts to answer one critical question: does financial development Granger-cause poverty reduction in Tanzania? In other words, does the financial development that has been experienced in Tanzania – ever since the onset of financial reforms in the 1990s – trickle down to the poor? Unlike some previous studies, we employ the recently developed autoregressive distributed lag (ARDL)-bounds testing approach to examine this linkage. In addition, we incorporate savings as an intermittent variable between financial development and poverty reduction in a trivariate setting. Our results show that there is an overwhelming long-run unidirectional causal flow from financial development to poverty reduction in Tanzania. This finding has important policy implications, as it shows that financial development trickles down to the poor in Tanzania.
The Impact of Standard Setting on Relevance and Reliability of Accounting Information: Lower of Cost or Market Accounting Reforms in China

During the period from 1998 to 2000, China implemented several new asset write-down regulations that mandate lower of cost or market accounting (LCM) for most non-cash assets. This is a study of the relevance and reliability of those regulations for investors in China. The study measures the association of net asset value with market value of equity and the association of accounting income with stock return, on both a historical cost accounting (HCA) basis and on an LCM basis. A fixed-effects model controlling both year and firm effects is used in a balanced panel sample. The panel regressions show high levels of explanatory power. LCM values can be relevant but may be measured with sufficient error that they do not improve the prediction of firm values. Reliability is measured using non-nested, overlapping model comparison tests (J and Cox). The paper also considers whether discretionary motivations influence the amount of write-down. The study supports the relevance of LCM reforms, but finds that reliability is not increased over HCA during the period under study. Reliability appears to be reduced by the voluntary nature of LCM provisions during part of the period and by the effects of opportunism for some firms in the sample.
Agency Costs of Stakeholders and Capital Structure: International Evidence

Purpose - This paper examines relationship between bargaining powers of creditors as well as employees and financial leverage across countries. The purpose of this paper is to explore roles of creditors and employees in capital structure decisions under different legal and political regimes across countries. Design/methodology/approach - Using country-level creditor rights index and labor rights index as a proxy for bargaining powers of creditors and employees, respectively, the author addresses the interaction between creditors as well as employees and shareholders. The paper tests the impact of employee rights and creditor rights on capital structure across countries. Findings -The author finds a positive relationship between employee rights and firms' use of debt and a negative relationship between creditor rights and firm debt ratio. Social implications -The paper provides a new perspective to interpret international variation in financial leverage in the world. The results obtained from this paper help us to understand financial leverage in different countries with various corporate governance mechanisms. Originality/value -This paper takes all stakeholders into account when studying agency problems; it explores the role of creditors and employees in financing decision making under various corporate governance patterns and political and legal systems across countries.
Foreign liquidity to real estate market: Ripple effect and housing price dynamics

Globalisation enables foreign liquidity to access local property markets. This paper depicts a strong connection between foreigners’ property acquisitions and regional housing price movements in Singapore. Testing structure breaks also illustrates a ripple effect of prices from the central city to suburbs. A structural vector autoregression incorporates these two observations. Impulse-response function and forecast-error variance decomposition show that central region’s foreign-liquidity shocks can greatly impact housing price growth in not only the central region but also the non-central region where foreign buyers are inactive. The ripple effect of prices plays an important role. Non-central region’s foreign-liquidity shocks, in contrast, have small effects on both regions. Impacts of foreign-liquidity shocks can reach the public-housing market, where foreigners’ participation is prohibited. The findings are useful to policy makers who consider regulations of foreign home buyers as an instrument to stabilise housing markets.
Trickle-down or Rising Tide? Lessons on Mainstreaming Gender Policy from Colombia and South Africa

As a result of the United Nations Decade for Women (1976–1985) many member states of the United Nations in the South put in place some form of national machinery for the advancement of women. This paper considers that process, identifying three main phases. The first was heavily overlaid by the agendas of international development agencies and coincided with efforts to advance a "women in development" or WID agenda within international development cooperation. The second, explored here in relation to Colombia, saw a shift towards attempts to institutionalize gender awareness in development policy, the so-called "gender and development" or GAD approach. Against this background, the later South African experience is evaluated. It is argued that this potentially represents a third and distinguishable phase in the establishment of national machineries. Here structures were set up in the context of less aid dependence than many other countries and as a result of a process that was largely internally driven. Nevertheless, South Africa enjoyed tremendous support from international women’s networks and lessons were learnt from past experience elsewhere, both positive and negative. The South African approach to advancing gender equality is arguably the most progressive to be found anywhere. What remains to be seen is whether it will be possible to implement, given the persistence of poverty and inequality nationally and South Africa’s increasing identification with international neo-liberal agendas.
A double mobility acetabular implant for primary hip arthroplasty in patients at high risk of dislocation.

INTRODUCTION Dislocation following total hip replacement continues to be a problem for which no completely satisfactory solution has been found. Several methods have been proposed to reduce the incidence of hip dislocations with varying degrees of success, including elevated rim liners, constrained liners and large diameter bearings. We present our experience with the double mobility acetabular component in patients at high risk of instability. METHODS This was a retrospective review of 65 primary total hip arthroplasties in 55 patients (15 men, 40 women), performed between October 2005 and November 2009. The majority (80%) of patients had at least two and 26% had at least three risk factors for instability. The mean age was 76 years (range: 44-92 years). The patients were followed up for a mean duration of 60 months (range: 36-85 months). RESULTS Fourteen patients died and one was lost to follow-up, leaving fifty hips for final assessment. Until the final follow-up appointment, no patients had dislocation and none required revision surgery. The mean Oxford hip score improved from 45.0 to 26.5 (p<0.0001). The mean Merle d'Aubigné pain score improved from 1.4 to 4.9 (p<0.0001), the walking score from 2.3 to 3.1 (p<0.07) and the absolute hip function score from 5.4 to 10.8 (p<0.0001). There were no clinical or radiographic signs of loosening. CONCLUSIONS The double mobility acetabular component was successful at preventing dislocation during early to medium-term follow-up. However, as data are still lacking with regard to polyethylene wear rates at the additional bearing surface, it would be prudent to restrict the use of this implant to selected patients at high risk of instability.
Economies of Scale and Economies of Scope in Multiproduct Financial Institutions: A Study of British Columbia Credit Unions

This paper investigates the production technology facing computerized credit unions in Canada. A full system of translog cost equations is estimated in order to test for economies of scale, economies of scope, and other production characteristics in a multiproduct context. The regression results indicate that most of the credit unions in our sample experience significant increasing returns to scale as they expand their level of output. There is also evidence of cost complementarity or economies of scope in their mortgage and other lending activities. As a result, legislation which limits the ability of credit unions to grow and diversify will likely raise the operating costs of this important group of financial institutions. Additional structural tests of the most general translog specification suggest that none of the restrictive production conditions commonly imposed by other researchers using Cobb-Douglas and CES specifications provide a valid representation of credit union technology. The results of many earlier studies are therefore open to question. THIS PAPER PRESENTS A number of structural tests of the production technology facing large computerized credit unions in Canada. A full system of translog cost equations is estimated using detailed cross-sectional data on British Columbia credit unions. The parameter estimates obtained from our multiproduct specification allow us to test for economies of scale, economies of scope, and factor substitution. Unlike many earlier studies, the present paper introduces the various outputs as separate variables instead of crudely proxying them with a single output measure such as total assets, the total number of loans, or the number of depositors. By explicitly recognizing the multiproduct nature of the intermediation process, we are able to address more interesting production questions and remove some of the bias caused by misspecification and measurement error in simpler Approaches. The flexible translog specification allows us to estimate the sensitivity of costs to proportionate increases in all outputs (economies of scale), as well as the cost savings firms realize by producing several outputs jointly rather than specializing in the production of one (economies of scope). The test results reported in the latter part of the paper suggest that increasing returns to scale exist in almost all of the credit unions in our sample. Though
Clinical implications of JUPITER in a contemporary European population: the EPIC-Norfolk prospective population study.

AIMS Justification for the Use of statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) has raised several points of debate. We quantified the proportion of individuals meeting the JUPITER criteria, determined their risk profile, and their risk of coronary heart disease (CHD) events during a long-term follow-up in a contemporary European cohort. METHODS AND RESULTS A total of 25 639 participants aged between 45 and 79 years were followed for 11.4 ± 2.8 years in EPIC-Norfolk population cohort. A total of 8397 individuals with complete data available were considered potentially eligible for primary prevention. A total of 846 (10.1%) individuals fulfilled the JUPITER criteria [low-density lipoprotein cholesterol-C (LDL-C) <3.4 mmol/L/C-reactive protein ≥ 2 mg]. This group had a 10-person-year event rate of 14.6% compared with 7.0% for those with LDL-C <3.4 mmol/L/C-reactive protein <2 mg (P = 0.001); the corresponding adjusted hazard ratio for future CHD was 1.70 (95% CI: 1.31-2.21). The group fulfilling JUPITER criteria had significantly higher CHD risk compared with those with LDL-C ≥ 3.4 mmol/L and C-reactive protein <2 mg/L. Among individuals who did not qualify for statin therapy based on the Society of Cardiology Systematic COronary Risk Evaluation (SCORE) (n = 4652) or ATP III criteria (n = 4466), 18.1 and 18.9%, respectively, would have qualified using the JUPITER criteria. CONCLUSION In this European cohort, JUPITER-eligible individuals had significantly higher event rates compared with those with LDL-C <3.4 mmol/L/C-reactive protein <2 mg and LDL-C ≥ 3.4 mmol/L/C-reactive protein <2 mg/L. Application of the JUPITER criteria qualified almost one-fifth of the population for statin therapy that otherwise would not have qualified based on SCORE or ATP III criteria.
Glucose-regulated insulin production in hepatocytes.

BACKGROUND A gene-therapy-based treatment of type 1 diabetes mellitus requires the development of a surrogate beta cell that can synthesize and secrete functionally active insulin in response to physiologically relevant changes in ambient glucose levels. Failure to duplicate the storage-granule-based mechanism of insulin secretion of beta cells, however, has made it difficult to develop a surrogate beta cell. The authors' strategy for achieving glucose-dependent insulin secretion relies on glucose-responsive transcription of insulin mRNA and the constitutive secretory pathway of liver cells. METHODS Insulin gene constructs containing three S14-based glucose-inducible regulatory elements, the liver-specific albumin promoter, and the human insulin cDNA modified for furin cleavage compatibility, were prepared and evaluated for biologic function in hepatocytes, in vitro, and in diabetic rats in vivo. RESULTS The authors' insulin gene constructs induced insulin expression in hepatocytes. All detectable insulin produced by transduced hepatocytes in vitro was secreted, and the amount was dependent on the concentration of glucose and the duration of glucose stimulation. Analysis of in vivo functional efficacy of insulin gene therapy in streptozotocin-treated diabetic rats revealed the following: (1) fasting blood glucose levels were reduced to normal; (2) blood glucose levels of rats fed ad libitum were significantly reduced; and (3) peak blood glucose levels during oral glucose tolerance tests were significantly reduced. CONCLUSIONS These studies demonstrate in vivo glucose-regulated insulin secretion from an autologous non-beta cell leading to fasting euglycemia and an improved glucose tolerance, thereby supporting the feasibility of hepatocyte-based insulin gene-therapy for treatment of type 1 diabetes mellitus.
First-order kinetic model of Alzheimer's beta-amyloid fibril extension in vitro.

Recently, several studies have proposed models describing the mechanisms of Alzheimer's beta-amyloid fibril formation in vitro. However, these models are somewhat controversial and no exact kinetic analyses measuring the polymerization velocity as an indicator of the reaction, have thus far been available. We first formed beta-amyloid fibrils from a synthetic peptide, beta-amyloid(1-40), and determined the optimum conditions for quantitative fluorometry of these beta-amyloid fibrils with thioflavine T. Optimum fluorescence measurements of beta-amyloid fibrils were obtained at the excitation and emission wavelengths of 446 and 490 nm, respectively, with the reaction mixture containing 5 microM thioflavine T and 50 mM of glycine-NaOH buffer, pH 8.5. We then focused our study on the extension phase of beta-amyloid fibril formation in vitro. When beta-amyloid fibrils were incubated with monomeric beta-amyloid(1-40) in conditions where de novo seed formation does not occur, the extension of beta-amyloid fibrils was observed with electron microscopy. Quantitative fluorometry revealed that: (a) extension of amyloid fibrils proceeded by a pseudo-first-order exponential increase as measured by the fluorescence of thioflavine T; (b) the rate of extension was maximum around pH 7.5, and was dependent on the incubation temperature. Between 20 and 37 degrees C, good linearity was observed between the common logarithm of the initial rate and the reciprocal of the absolute temperature; (c) the rate of polymerization was found to be proportional to the product of beta-amyloid fibrils number concentration and the beta-amyloid(1-40) concentration; (d) the net rate of extension was the sum of the rates of polymerization and depolymerization. These results show that beta-amyloid fibril formation can be explained by a first-order kinetic model: i.e., the extension of beta-amyloid fibrils proceeds via the consecutive association of beta-amyloid(1-40) onto the ends of existing fibrils.
The Adjective Check List as an outcome measure: Assessment of personality change in psychotherapy

Abstract To investigate the value of the Adjective Check List (ACL) as a psychotherapy outcome measure, the ACL and Symptom Checklist-90-Revised (SCL-90-R) were administered at four times (before therapy, immediately after therapy, and at 6-month and 1-year follow-ups) to 38 patients in brief dynamic psychotherapy. High correlations between selected ACL scales and SCL-90-R Global Severity Index scores (GSI) were found. GSI change from before to after therapy correlated with change on the ACL scales. Changes from before to after therapy were detected for ACL scales at both the mean group and the individual levels. Because the ACL provides valuable information on personality dimensions as well as concurrent levels of distress, it is a particularly promising psychotherapy outcome measure.