Miracle-dz/UniFAR-FTUs huggingface dataset:
Microscopic anatomy and ultrastructure of the introvert of Priapulus caudatus and P. tuberculatospinosus (Priapulida)

Introverts of Priapulus caudatus and P. tuberculatospinosus bear 25 rows of scalids, as well as 8 spines and scattered papillae in the region the circumoral lip. These, as well as the first ring of pharyngeal teeth in P. tuberculatospinosus, are sensory organs. Although superficially they differ between species, they are all characterized by apical and/or subapical openings which are located on tiny cuticular tubules. All sensory organs contain cilia bearing bipolar receptor cells. The 8 sensory spines situated between the circumoral area and the beginning of the scalids are ultrastructurally similar to the scalids. The introvert and pharyngeal body walls, and associated muscles are described. © 1994 Wiley‐Liss, Inc.
Asynchronous Batch and PIR Codes from Hypergraphs

We propose a new model of asynchronous batch codes that allow for parallel recovery of information symbols from a coded database in an asynchronous manner, i.e., when different queries take different time to process. Then, we show that the graph-based batch codes studied by Rawat et at. are asynchronous. Further, we demonstrate that hypergraphs of Berge girth at least 4, respectively at least 3, yield graph-based asynchronous batch codes, respectively private information retrieval (PIR) codes. We prove the hypergraph-theoretic proposition that the maximum number of hyperedges in a hypergraph of a fixed Berge girth equals the quantity in a certain generalization of the hypergraph-theoretic (6,3)-problem, first posed by Brown, Erdős and Sós. We then apply the constructions and bounds by Erdős, Frankl and Rödl about this generalization of the $(6,3)-$ problem, known as the (3r-3,r)-problem, to obtain batch code constructions and bounds on the redundancy of the graph-based asynchronous batch and PIR codes. Finally, we show that the optimal redundancy $\rho (k)$ of graph-based asynchronous batch codes of dimension k with the query size $t=3$ is $2\sqrt {k}$. Moreover, for a general fixed value of $t\geq 4, \rho (k) =O(k^{1/(2-\epsilon)})$ for any small $\epsilon \gt 0$. For a general value of $t\geq 4, \displaystyle \lim _{k\rightarrow \infty }\rho (k)/\sqrt {k}=\infty. $
DNA Vaccine–Induced Long-Lasting Cytotoxic T Cells Targeting Conserved Elements of Human Immunodeficiency Virus Gag Are Boosted Upon DNA or Recombinant Modified Vaccinia Ankara Vaccination

DNA-based vaccines able to induce efficient cytotoxic T-cell responses targeting conserved elements (CE) of human immunodeficiency virus type 1 (HIV-1) Gag have been developed. These CE were selected by stringent conservation, the ability to induce T-cell responses with broad human leukocyte antigen coverage, and the association between recognition of CE epitopes and viral control in HIV-infected individuals. Based on homology to HIV, a simian immunodeficiency virus p27gag CE DNA vaccine has also been developed. This study reports on the durability of the CE-specific T-cell responses induced by HIV and simian immunodeficiency virus CE DNA-based prime/boost vaccine regimens in rhesus macaques, and shows that the initially primed CE-specific T-cell responses were efficiently boosted by a single CE DNA vaccination after the long rest period (up to 2 years). In another cohort of animals, the study shows that a single inoculation with non-replicating recombinant Modified Vaccinia Ankara (rMVA62B) also potently boosted CE-specific responses after around 1.5 years of rest. Both CE DNA and rMVA62B booster vaccinations increased the magnitude and cytotoxicity of the CE-specific responses while maintaining the breadth of CE recognition. Env produced by rMVA62B did not negatively interfere with the recall of the Gag CE responses. rMVA62B could be beneficial to further boosting the immune response to Gag in humans. Vaccine regimens that employ CE DNA as a priming immunogen hold promise for application in HIV prevention and therapy.
Long-term follow-up on health-related quality of life in major depressive disorder: a 2-year European cohort study

Background Major depressive disorder (MDD) is associated with significant impairments in health-related quality of life (HRQoL) and everyday functioning. This cohort study investigated the long-term development of HRQoL in patients with MDD and its association with patient characteristics, including depressive symptom severity and cognitive symptoms. Methods The Prospective Epidemiological Research on Functioning Outcomes Related to Major depressive disorder (PERFORM) study was a longitudinal cohort study conducted in 1,159 outpatients aged 18–65 years with MDD in France, Germany, Spain, Sweden, and the UK. The patients were either initiating antidepressant monotherapy or undergoing their first switch of antidepressant. HRQoL was assessed using the Medical Outcomes Study Short-Form 12-item Health Survey (SF-12) up to month 12 and the EuroQol Five Dimensions questionnaire up to month 24 (UK only). Depressive symptom severity was assessed up to month 24 by the patient-reported Patient Health Questionnaire and cognitive symptoms by the Perceived Deficit Questionnaire. Multivariate analyses were performed to identify patient characteristics associated with HRQoL. Results Mental HRQoL was severely impaired at baseline versus normative data (mean [SD] SF-12 mental component summary [MCS], 26.5 [9.2]); mean (SD) physical component summary (PCS) total score was 45.2 (12.1). SF-12 MCS improved over 12 months of follow-up (38.7 [11.6] at month 12), while SF-12 PCS remained stable (45.3 [11.1]). At each assessment time point, there was a clear pattern of lower SF-12 MCS and PCS total score in patients experiencing greater cognitive problems. The mean EuroQol Five Dimensions questionnaire utility index score generally decreased (i.e., worsened) with increasing severity of cognitive and depressive symptoms at all time points up to 24 months. Multivariate analyses identified both depression severity and cognitive symptoms as strongly and significantly associated with poor HRQoL. Conclusion These findings highlight the importance of recognizing and managing residual symptoms in patients with MDD, including the cognitive symptoms, to restore long-term psychosocial functioning.
Salinity Tolerance of Two Potato Cultivars (Solanum tuberosum) Correlates With Differences in Vacuolar Transport Activity

Potato is an important cultivated crop species and since it is moderately salt sensitive there is a need to develop more salt tolerant cultivars. A high activity of Na+ transport across the tonoplast in exchange for H+ is essential to reduce Na+ toxicity. The proton motive force (PMF) generated by the V-H+-ATPase and the V-H+-PPase energizes the Na+(K+)/H+ antiport. We compared the activity, gene expression, and protein levels of the vacuolar proton pumps and the Na+/H+ antiporters in two potato cultivars (Solanum tuberosum) contrasting in their salt tolerance (cv. Desiree; tolerant and Mozart; sensitive) grown at 0 and 60 mM NaCl. Tonoplast-enriched vesicles were used to study the pump activity and protein levels of the V-H+-ATPase and the V-H+-PPase and the activity of the Na+/H+ antiporter. Although salt stress reduced the V-H+-ATPase and the V-H+-PPase activity in both cultivars, the decline in H+ pump activity was more severe in the salt-sensitive cultivar Mozart. After salt treatment, protein amounts of the vacuolar H+ pumps decreased in Mozart but remained unchanged in the cultivar Desiree. Decreased protein amounts of the V-H+-PPase found in Mozart may explain the reduced V-H+-PPase activity found for Mozart after salt stress. Under non-stress conditions, protein amounts of V-H+-PPase were equal in both cultivars while the V-H+-PPase activity was already twice as high and remained higher after salt treatment in the cultivar Desiree as compared to Mozart. This cultivar-dependent V-H+-PPase activity may explain the higher salt tolerance of Desiree. Moreover, combined with reduced vacuolar H+ pump activity, Mozart showed a lower Na+/H+ exchange activity and the Km for Na+ is at least twofold lower in tonoplast vesicles from Desiree, what suggests that NHXs from Desiree have a higher affinity for Na+ as compared to Mozart. From these results, we conclude that the higher capacity in combination with the higher affinity for Na+ uptake can be an important factor to explain the differences in salt tolerance of these two potato cultivars.
Intra and Inter-Observer Reliability of Mobile Tablet PACS Viewer System vs. Standard PACS Viewing Station-Diagnosis of Acute Central Nervous System Events

Background and Purpose: The display resolution of the Apple iPad? is 1024 × 768 pixels, which is greater than that required for generating the typical CT or MRI images. The purpose of this study is to determine if specific CT and MR sequences can be interpreted accurately on mobile device/PACS software platforms when compared to a traditional stationary high resolution monitor/PACS radiological workstation. If so, this allows radiologists to provide comparable interpretation as if they were onsite at an imaging center or hospital. Materials and Methods: This study is an investigator initiated, single site, retrospective, nonrandomized, IRB approved study. Five radiologists were included in this study. Each independently interpreted specific CT and MR sequences on traditional high-resolution LCD monitors via eFilm? software as well as an iPad? mobile device using Osirix? software program. Repeat interpretations were performed, with 4 weeks minimum interval between interpretations of each patient. This investigation included: 50 patients with CTA perfusion imaging, 50 patients with MRI of the brain, and 50 patients with MRI of the spine, which were image study orders generated through emergency room requests. Subsequently, interpretive results of each radiologist for each patient were statistically compared to evaluate for intra-observer and inter-observer reliability. Results: The parameters set within the CTA perfusion brain studies demonstrated excellent intra-observer variability. All of the parameters within the MRI brain studies demonstrated excellent intra-observer variability with a Cohen’s kappa value > 0.75. The Cohen’s kappa values for the board certified neuroradiologist demonstrated excellent variability for all parameters; the resident radiologists had good variability, with a majority of kappa values near 0.75. Conclusions: The data and statistical analysis demonstrated that portable mobile devices such as the Apple iPad? can display adequate resolution of CT and MRI sequences to accurately diagnose acute central nervous system injuries and other non-acute pathology.
Scaling Up Large-Scale Graph Processing for GPU-Accelerated Heterogeneous Systems

Not only with the large host memory for supporting large scale graph processing, GPU-accelerated heterogeneous architecture can also provide a great potential for high-performance computing. However, few existing heterogeneous systems can exploit both hardware advantages to enable the scale-up performance for graph processing due to the limited CPU-GPU transmission efficiency. In this paper, we investigate the transmission inefficiency problem of heterogeneous graph systems. Our key insight is that the transmission efficiency for heterogeneous graph processing can be greatly improved by simply iterating each subgraph multiple times (rather than only once in prior work) in the GPU, further enabling to obtain the improvable efficiency of heterogeneous graph systems by enhancing GPU processing capability. We therefore present Seraph, with the highlights of {\em pipelined} subgraph iterations and {\em predictive} vertex updating, to cooperatively maximize the effective computations of GPU on graph processing. Our evaluation on a wide variety of large graph datasets shows that Seraph outperforms state-of-the-art heterogeneous graph systems by 5.42x (vs. Graphie) and 3.05x (vs. Garaph). Further, Seraph can be significantly scaled up over Graphie as fed with more computing power for large-scale graph processing.
A measurement of CMB cluster lensing with SPT and DES year 1 data

Clusters of galaxies gravitationally lens the cosmic microwave background (CMB) radiation, resulting in a distinct imprint in the CMB on arcminute scales. Measurement of this effect offers a promising way to constrain the masses of galaxy clusters, particularly those at high redshift. We use CMB maps from the South Pole Telescope Sunyaev–Zel'dovich (SZ) survey to measure the CMB lensing signal around galaxy clusters identified in optical imaging from first year observations of the Dark Energy Survey. The cluster catalogue used in this analysis contains 3697 members with mean redshift of z = 0.45. We detect lensing of the CMB by the galaxy clusters at 8. 1σ significance. Using the measured lensing signal, we constrain the amplitude of the relation between cluster mass and optical richness to roughly 17 percent precision, finding good agreement with recent constraints obtained with galaxy lensing. The error budget is dominated by statistical noise but includes significant contributions from systematic biases due to the thermal SZ effect and cluster miscentring.
Content-based Video Relevance Prediction Challenge: Data, Protocol, and Baseline

Video relevance prediction is one of the most important tasks for online streaming service. Given the relevance of videos and viewer feedbacks, the system can provide personalized recommendations, which will help the user discover more content of interest. In most online service, the computation of video relevance table is based on users' implicit feedback, e.g. watch and search history. However, this kind of method performs poorly for "cold-start" problems - when a new video is added to the library, the recommendation system needs to bootstrap the video relevance score with very little user behavior known. One promising approach to solve it is analyzing video content itself, i.e. predicting video relevance by video frame, audio, subtitle and metadata. In this paper, we describe a challenge on Content-based Video Relevance Prediction (CBVRP) that is hosted by Hulu in the ACM Multimedia Conference 2018. In this challenge, Hulu drives the study on an open problem of exploiting content characteristics directly from original video for video relevance prediction. We provide massive video assets and ground truth relevance derived from our really system, to build up a common platform for algorithm development and performance evaluation.
M+M3+2As(HAsO4)6 and α- and β-M+M3+(HAsO4)2 (M+M3+ = RbAl or CsFe): six new compounds crystallizing in three closely related structure types.

The crystal structures of hydrothermally synthesized (T = 493 K, 7-9 d) rubidium aluminium bis[hydrogen arsenate(V)], RbAl(HAsO4)2, caesium iron bis[hydrogen arsenate(V)], CsFe(HAsO4)2, rubidium dialuminium arsenic(V) hexakis[hydrogen arsenate(V)], RbAl2As(HAsO4)6, and caesium diiron arsenic(V) hexakis[hydrogen arsenate(V)], CsFe2As(HAsO4)6, were solved by single-crystal X-ray diffraction. The four compounds with the general formula M+M3+(HAsO4)2 adopt the RbFe(HPO4)2 structure type (R-3c) and a closely related new structure type, which is characterized by a different stacking order of the building units, leading to noncentrosymmetric space-group symmetry R32. The second new structure type, with the general formula M+M3+2As(HAsO4)6 (R-3c), is also a modification of the RbFe(HPO4)2 structure type, in which one third of the M3+O6 octahedra are replaced by AsO6 octahedra, and two thirds of the voids in the structure, which are usually filled by M+ cations, remain empty to achieve charge balance.
Morning blood pressure surge: pathophysiology, clinical relevance and therapeutic aspects

Morning hours are the period of the day characterized by the highest incidence of major cardiovascular events including myocardial infarction, sudden death or stroke. They are also characterized by important neurohormonal changes, in particular, the activation of sympathetic nervous system which usually leads to a rapid increase in blood pressure (BP), known as morning blood pressure surge (MBPS). It was hypothesized that excessive MBPS may be causally involved in the pathogenesis of cardiovascular events occurring in the morning by inducing hemodynamic stress. A number of studies support an independent relationship of MBPS with organ damage, cerebrovascular complications and mortality, although some heterogeneity exists in the available evidence. This may be due to ethnic differences, methodological issues and the confounding relationship of MBPS with other features of 24-hour BP profile, such as nocturnal dipping or BP variability. Several studies are also available dealing with treatment effects on MBPS and indicating the importance of long-acting antihypertensive drugs in this regard. This paper provides an overview of pathophysiologic, methodological, prognostic and therapeutic aspects related to MBPS.
Evidence-Based Practice in the Hospital Setting: Views of Interdisciplinary Therapy Practitioners.

BACKGROUND In the United States' changing health care climate, an updated picture of evidence-based practice (EBP) in the hospital setting is needed. Researchers explored EBP activities that interdisciplinary therapy team members used most frequently to acquire and appraise clinical evidence, therapists' perceptions of EBP, and barriers and enablers to EBP implementation within two similar acute-care hospitals in the Midwest. METHODS An electronic survey was distributed to 190 therapy practitioners working in two acute-care hospital settings. Eighty-four practitioners completed the 54-item electronic survey (n=84; 44% response rate). The sample consisted of 21 speech-language pathologists, 19 occupational therapists, 30 physical therapists, and 14 physical or occupational therapy assistants. RESULTS Practitioners reported utilizing past experience and colleague interaction most frequently to acquire and appraise evidence; participants used self-reflective activities, such as journal clubs and carrying out research, infrequently. All disciplines placed high personal and professional value on EBP but indicated only moderate amounts of workplace support and personal preparedness to acquire, critique, and implement evidence. All disciplines indicated time was the largest EBP barrier. For enablers of EBP, disciplines responded differently, reporting support in the form of resources, training, and departmental goals. CONCLUSION Pooled results indicated EBP activities used most frequently were of the lowest levels of clinical evidence; more effective EBP activities, such as self-reflection and participation in research, were rarely used. Hospital-based interdisciplinary therapy practitioners valued EBP but reported workplace constraints limiting implementation. Barriers to EBP were similar across disciplines, while enablers differed between disciplines.
Attachment comes of age: adolescents’ narrative coherence and reflective functioning predict well-being in emerging adulthood

ABSTRACT This study investigated the effects of adolescents’ attachment security and reflective functioning (RF) (assessed by the adult attachment interview [AAI]) in the prediction of well-being in adulthood. Adolescents (N = 79; M = 14.6 years old; SD = 3.5 years) completed the AAI at Time 1 (T1), which was subsequently coded for inferred attachment experiences, narrative coherence, and RF by three nonoverlapping teams of raters. Participants completed the Psychological General Well-being Index at T1 and 8 years later (Time 2, T2). Analyses showed that (a) both adolescent narrative coherence and RF were significant predictors of almost all indices of well-being at T2 in adulthood; (b) both narrative coherence and RF indirectly linked inferred loving parental care and T2 well-being; (c) when included in the same model, RF was a significant indirect effect linking inferred loving parental care and T2 well-being. These findings contribute to theory in suggesting that both RF and narrative coherence are predictive of subsequent psychological well-being and operate as links between inferred parental care and subsequent adjustment. Possible mechanisms underlying these findings are discussed.
ALMN: Deep Embedding Learning with Geometrical Virtual Point Generating

Deep embedding learning becomes more attractive for discriminative feature learning, but many methods still require hard-class mining, which is computationally complex and performance-sensitive. To this end, we propose Adaptive Large Margin N-Pair loss (ALMN) to address the aforementioned issues. Instead of exploring hard example-mining strategy, we introduce the concept of large margin constraint. This constraint aims at encouraging local-adaptive large angular decision margin among dissimilar samples in multimodal feature space so as to significantly encourage intraclass compactness and interclass separability. And it is mainly achieved by a simple yet novel geometrical Virtual Point Generating (VPG) method, which converts artificially setting a fixed margin into automatically generating a boundary training sample in feature space and is an open question. We demonstrate the effectiveness of our method on several popular datasets for image retrieval and clustering tasks.
Signal and Noise Statistics Oblivious Orthogonal Matching Pursuit

Orthogonal matching pursuit (OMP) is a widely used algorithm for recovering sparse high dimensional vectors in linear regression models. The optimal performance of OMP requires \textit{a priori} knowledge of either the sparsity of regression vector or noise statistics. Both these statistics are rarely known \textit{a priori} and are very difficult to estimate. In this paper, we present a novel technique called residual ratio thresholding (RRT) to operate OMP without any \textit{a priori} knowledge of sparsity and noise statistics and establish finite sample and large sample support recovery guarantees for the same. Both analytical results and numerical simulations in real and synthetic data sets indicate that RRT has a performance comparable to OMP with \textit{a priori} knowledge of sparsity and noise statistics.
Enantioselective Aldol Reactions and Michael Additions Using Proline Derivatives as Organocatalysts

Six compounds including five proline derivatives have been prepared and tested as chiral organocatalysts for enantioselective aldol reactions and Michael additions. The enantiomeric excesses, which are highly dependent on the molecular structure of catalysts as well as experimental conditions, have reached over 98%.