Miracle-dz/UniFAR-FTUs huggingface dataset:
Occupational dust exposure and the risk of laryngeal cancer in Turkey.

OBJECTIVES A hospital-based case-referent study was conducted to identify occupational risk factors for laryngeal cancer. In a previous report an association was found between laryngeal cancer and occupations with potential dust exposure; a job-exposure matrix was developed to aid further evaluation of laryngeal cancer risks from five occupational dust exposures. METHODS Among 7631 cancer cases from the Okmeydani Hospital, Istanbul, between 1979 and 1984, 958 larynx cancer cases were identified among men. After exclusions, 940 laryngeal cancer cases and 1519 referents were available. A standardized questionnaire was used to obtain basic information on the patients. Seven-digit standard occupational and industrial codes were created to classify the job and industrial titles. A job-exposure matrix was developed for occupational dusts, including silica, asbestos, wood, cotton, and grain, and age-, smoking-, and alcohol-adjusted odds ratios (OR) and 95% confidence intervals (95% CI) were calculated to evaluate risks of laryngeal cancer. RESULTS An excess of laryngeal cancer occurred for workers potentially exposed to silica and cotton dust, particularly for supraglottic cancer (OR 1.8, 95% CI 1.3-2.3, for silica and OR 1.6, 95% CI 1.1-2.5, for cotton dust), and there was a significant dose-response relationship with silica exposure. No relationship was found between laryngeal cancer and asbestos, grain, or wood dust exposures. CONCLUSION Laryngeal cancer, especially supraglottic tumors, is associated with silica and cotton dust exposures in Turkey.
Fish intake, mercury, long-chain n-3 polyunsaturated fatty acids and risk of stroke in northern Sweden

Results of previous studies on fish intake and stroke risk have been inconclusive. Different stroke types have often not been separated. Our aim was to elucidate whether intake of fish, Hg or the sum of proportions of fatty acids EPA (20 : 5n-3) and DHA (22 : 6n-3) influence the risk of haemorrhagic or ischaemic stroke. Within a population-based cohort from a community intervention programme, 369 stroke cases and 738 matched controls were identified and included in the present nested case–control study. Information on fish intake had been recorded at recruitment, i.e. before diagnosis. Hg levels were determined in erythrocyte membranes, also collected at recruitment, and the relative content of fatty acids was measured in erythrocyte membranes or plasma phospholipids. The results showed that in women there was a non-significant decrease in stroke risk with increasing fish intake (OR 0·90 (95 % CI 0·73, 1·11) per meal per week). The risk in women differed significantly (P = 0·03) from that in men, in whom the OR for stroke rose with increasing fish intake (OR 1·24 (95 % CI 1·01, 1·51) per meal per week). The corresponding risk in men for Hg was 0·99 (95 % CI 0·93, 1·06), and for the sum of proportions of EPA and DHA 1·08 (95 % CI 0·92, 1·28). We conclude that the relationship between stroke risk and fish intake seems to be different in men and women. Increased levels of EPA and DHA do not decrease the risk for stroke and there is no association between stroke risk and Hg at these low levels.
Predictors of endothelial dysfunction in young women with polycystic ovary syndrome.

CONTEXT Women with polycystic ovary syndrome (PCOS) may be at increased risk for cardiovascular disease. Endothelial dysfunction is an early marker of atherosclerosis. OBJECTIVES The objectives of this study were to 1) compare endothelial function in young women with PCOS and regularly menstruating control women, and 2) to identify the determinants of endothelial function and investigate its relationship with body mass index in women with PCOS. DESIGN This was a cross-sectional study. SETTING This study was conducted at a tertiary cardiovascular research center. PATIENTS Sixty-two young women with PCOS (mean age, 22.7 yr) and 17 control women, matched as a group for age and body mass index, were studied. Twenty-three women with PCOS were lean, 21 were overweight, and 18 were obese. MAIN OUTCOME MEASURES Endothelium-dependent and -independent vascular function was assessed by measuring flow-mediated dilation (FMD) and nitrate-mediated dilation in the brachial artery (diameter change during hand hyperemia and after sublingual glyceryl trinitrate administration, respectively). RESULTS FMD and nitrate-mediated dilation were significantly lower in PCOS than in control women (reduced by approximately 50 and 25%, respectively; both P < 0.0005). Insulin resistance, total testosterone, and total cholesterol were independent predictors of FMD, accounting for 21, 10, and 9% of the variance, respectively (P < 0.005 for all). A trend of deterioration in FMD from lean to overweight and obese PCOS women was observed, but differences among groups were not statistically significant. CONCLUSIONS Women with PCOS have significant endothelial dysfunction at an early age (i.e. early 20s), and largely independent of obesity. This suggests that women with PCOS are at increased risk for early onset cardiovascular disease and may gain particular benefit from measures to improve endothelial function.
Group influences on individuals' drinking and other drug use at clubs.

OBJECTIVE This article examines effects of the social group on individual alcohol and drug use upon entry and exit from the club. Based on collected biological measurements of alcohol and other drug use, this study explores whether social group indicators (e.g., group characteristics) are predictive of alcohol and other drug use for individual club patrons. METHOD A total of 368 social groups, representing 986 individuals (50.7% female), were anonymously surveyed, and biological measures of alcohol and other drug use were collected at entrance and exit to clubs on a single evening. Both individual and group-level indicators were assessed. Because data were clustered by club, event, and group, mixed-model regressions were conducted to account for non-independence. RESULTS Group indicators of high blood alcohol concentration were being in a group that intends to get drunk, that has at least one member who regularly gets drunk, and that has discrepancies in its expectations regarding drug use. Group indicators related to cocaine use were high levels of drug use expected among group members, little discrepancy among the group members regarding the drug use expected, and high levels of intentions to get drunk. In addition, older groups were more likely to have higher levels of cocaine use. There were less consistent findings regarding group effects on marijuana use. The most consistent finding was that high drug use expectations were related to higher levels of marijuana use. CONCLUSIONS Together, these data suggest that strategies should focus on recognizing group indicators as risks for group members. Promoting social responsibility for group members may create safer club experiences among young adults. These efforts could model designated-driver programs as a way to increase safety and social responsibility.
Physical Activity on Prescription (PAP), in patients with metabolic risk factors. A 6-month follow-up study in primary health care

There is strong evidence that inadequate physical activity (PA) leads to an increased risk of lifestyle-related diseases and premature mortality. Physical activity on prescription (PAP) is a method to increase the level of PA of patients in primary care, but needs further evaluation. The aim of this observational study was to explore the association between PAP-treatment and the PA level of patients with metabolic risk factors and the relationship between changes in the PA level and health outcomes at the 6 month follow-up. This study included 444 patients in primary care, aged 27–85 years (56% females), who were physically inactive with at least one component of metabolic syndrome. The PAP-treatment model included: individualized dialogue concerning PA, prescribed PA, and a structured follow-up. A total of 368 patients (83%) completed the 6 months of follow-up. Of these patients, 73% increased their PA level and 42% moved from an inadequate PA level to sufficient, according to public health recommendations. There were significant improvements (p≤ 0.05) in the following metabolic risk factors: body mass index, waist circumference, systolic blood pressure, fasting plasma glucose, cholesterol, and low density lipoprotein. There were also significant improvements regarding health-related quality of life, assessed by the Short Form 36, in: general health, vitality, social function, mental health, role limitation-physical/emotional, mental component summary, and physical component summary. Regression analysis showed a significant association between changes in the PA level and health outcomes. During the first 6-month period, the caregiver provided PAP support 1–2 times. This study indicates that an individual-based model of PAP-treatment has the potential to change people’s PA behavior with improved metabolic risk factors and self-reported quality of life at the 6 month follow-up. Thus, PAP seems to be feasible in a clinical primary care practice, with minimum effort from healthcare professionals.
Nectin-1/HveC mediates herpes simplex virus type 1 entry into primary human sensory neurons and fibroblasts

Immunocytochemistry detects nectin-1/HveC, nectin-2/HveB, and HVEM/HveA on the surface of sensory neurons and fibroblasts grown as primary cultures from human dorsal root ganglia. Viral entry into these cultured cells was assayed by infection with a recombinant herpes simplex virus type 1 (HSV-1) expressing green fluorescent protein. Soluble, truncated nectin-1 polypeptide, as well as polyclonal and monoclonal antibodies against nectin-1, inhibited infection of neurons, whereas polypeptides and antibodies capable of inhibiting HSV-1 interaction with nectin-2 and herpesvirus entry mediator (HVEM) failed to prevent infection of neuronal cells. These results demonstrate that nectin-1 is the primary receptor for HSV-1 entry into human fetal neurons. Viral entry into fibroblasts was also reduced by soluble nectin-1 but not by soluble HVEM. However, in contrast to the results obtained with neurons, antibodies against receptors failed to inhibit entry into fibroblasts, indicating that unlike neurons, fibroblasts have multiple receptors or mechanisms for HSV-1 entry.
Reliability of Task-Based fMRI for Preoperative Planning: A Test-Retest Study in Brain Tumor Patients and Healthy Controls

Background Functional magnetic resonance imaging (fMRI) continues to develop as a clinical tool for patients with brain cancer, offering data that may directly influence surgical decisions. Unfortunately, routine integration of preoperative fMRI has been limited by concerns about reliability. Many pertinent studies have been undertaken involving healthy controls, but work involving brain tumor patients has been limited. To develop fMRI fully as a clinical tool, it will be critical to examine these reliability issues among patients with brain tumors. The present work is the first to extensively characterize differences in activation map quality between brain tumor patients and healthy controls, including the effects of tumor grade and the chosen behavioral testing paradigm on reliability outcomes. Method Test-retest data were collected for a group of low-grade (n = 6) and high-grade glioma (n = 6) patients, and for matched healthy controls (n = 12), who performed motor and language tasks during a single fMRI session. Reliability was characterized by the spatial overlap and displacement of brain activity clusters, BOLD signal stability, and the laterality index. Significance testing was performed to assess differences in reliability between the patients and controls, and low-grade and high-grade patients; as well as between different fMRI testing paradigms. Results There were few significant differences in fMRI reliability measures between patients and controls. Reliability was significantly lower when comparing high-grade tumor patients to controls, or to low-grade tumor patients. The motor task produced more reliable activation patterns than the language tasks, as did the rhyming task in comparison to the phonemic fluency task. Conclusion In low-grade glioma patients, fMRI data are as reliable as healthy control subjects. For high-grade glioma patients, further investigation is required to determine the underlying causes of reduced reliability. To maximize reliability outcomes, testing paradigms should be carefully selected to generate robust activation patterns.
Bactericidal activity of pyrazinamide and clofazimine alone and in combinations with pretomanid and bedaquiline.

RATIONALE New regimens to shorten tuberculosis treatment and manage patients with drug-resistant tuberculosis who are infected with HIV are urgently needed. Experimental and clinical evidence suggests that the new drugs bedaquiline (B) and pretomanid (Pa), combined with an existing drug, pyrazinamide (Z), and a repurposed drug, clofazimine (C), may assist treatment shortening of drug-susceptible and drug-resistant tuberculosis. OBJECTIVES To evaluate the 14-day bactericidal activity of C and Z in monotherapy and in combinations with Pa and B. METHODS Groups of 15 treatment-naive, sputum smear-positive patients with pulmonary tuberculosis were randomized to receive combinations of B with Z-C, Pa-Z, Pa-Z-C, and Pa-C, or C or Z alone, or standard combination treatment for 14 days. The primary endpoint was the mean daily fall in log10 Mycobacterium tuberculosis CFU per milliliter sputum estimated by joint nonlinear mixed-effects Bayesian regression modeling. MEASUREMENTS AND MAIN RESULTS Estimated activities were 0.167 (95% confidence interval [CI], 0.075-0.257) for B-Pa-Z, 0.151 (95% CI, 0.071-0.232) for standard treatment, 0.124 (95% CI, 0.035-0.214) for B-Z-C, 0.115 (95% CI, 0.039-0.189) for B-Pa-Z-C, and 0.076 (95% CI, 0.005-0.145) for B-Pa-C. Z alone had modest activity (0.036; 95% CI, -0.026 to 0.099). C had no activity alone (-0.017; 95% CI, -0.085 to 0.053) or in combinations. Treatments were well tolerated and safe. CONCLUSIONS B-Pa-Z, including two novel agents without resistance in prevalent M. tuberculosis strains, is a potential new tuberculosis treatment regimen. C had no measurable activity in the first 14 days of treatment. Clinical trial registered with www.clinicaltrials. gov (NCT 01691534).
Filter Bubble Effects on Deliberative Democracy? – A Realist Synthesis of Empirical Research

In 2011 Eli Pariser coined the term ‘filter bubble’ and warned that online algorithm driven filters based on users’ click behaviour, would risk to reduce the diversity of public discourses and thereby deliberative democracy. Through the multidisciplinary and iterative Realist Synthesis method, the aim of the study has been to synthesise empirically based understanding of how online algorithm driven filter bubbles affect public discourses and deliberative democracies. On micro level, the result confirms selection bias and corresponding confirmation bias in the contexts of online feed oriented political messages that would constitute a necessary key condition for algorithm driven filter bubbles to emerge. However, none of the studies in the sample have explicitly investigated effects of these filters on political attitudes. Therefore, filter bubble effects on public discourses and democracy can neither be verified, measured nor refuted. On the meso level, the presence of online clusters of biased online political content, that could serve as foundations for online echo chambers, are shown, and their inner workings partly explained. Also shown is that these environments have the potential to reduce the diversity of political discourses, but also to support polarisation and radicalisation. On macro level the results indicate that national borders, power distribution of political websites, and personalisation through localisation, language and political topics, differentiate what Internet users see when surfing or searching the web in a way that could affect diversity of global or national political discourses. The results also indicate stratification of discourses where some users with high topic involvement, curiosity or interest in politics are relatively immune to political selection bias, while other groups of less interested or knowledgeable followers, are likely to be reached by less diversified messages. Limited to the sampled research, this meta study shows that contemporary Internet brings challenges to deliberative democracy, but until further not because of algorithm driven filter bubbles.
An assessment of the emotional intelligence of health workers: A scale validation approach

This study aims to assess health workers’ level of emotional intelligence (EI) in Accra North and recommend a simple but robust statistical technique for compulsorily validating EI measurement scales. ,The researchers used a self-reported questionnaire to collect data from 1,049 randomly selected health workers. Two non-nested models, BNK MODEL and CMODEL, were compared to see which of them better fits the study population and yields a better level of EI. The one-sample and independent-samples t-tests, exploratory factor analysis and confirmatory factor analysis were used to present results. ,The study found that health workers were appreciably emotionally intelligent for both models at the 5 per cent significance level. However, EI was higher for the CMODEL. The CMODEL also better fits the study population (χ2 = 132.2, p = 0.487, Akaike information criterion = 124.932) and thus better underlies EI in it. This study recommends proper validation of the two EI scales evaluated in this study, and possibly other scales, before the use of their data in research, as failure to do so could lead to unrealistic results. ,Apart from its contribution to the literature, this study provides a robust statistical approach for assessing health workers’ EI and validating EI scales. By comparing two models of EI in the validation process, this paper suggests that the researcher’s choice of a measurement scale can influence his/her results.
Flow observations in elastic stenosis biomodel with comparison to rigid-like model.

BACKGROUND Plaques in blood vessels exhibit a wide range of stiffness depending on disease conditions: stiffness is an important factor in plaque behavior. The geometrical change in plaque based on its behavior can affect blood flow patterns. Thus, it is important to study both blood flow and deformation of plaques and blood vessels. OBJECTIVE This study aims to identify the differences in flow conditions between in vitro models to discuss experimental materials for arterial wall and flow observation. METHODS In order to observe the blood flow pattern and plaque deformation simultaneously, a PVA-H stenosis model was used. In addition, a silicone model was also used as a rigid-like model for comparison with the PVA-H model. PIV was employed to measure the flow velocity distribution and determine the flow levels in the models. RESULTS PVA-H model exhibits expansion with an increase in upstream pressure and silicone model maintains the diameter. The expansion depends on their mechanical properties and influences flow conditions such as velocity changes and RAP in the parent artery. The balance between the expansion and change in flow conditions determines the final geometries of PVA-H model and flow pattern. CONCLUSIONS The results suggest that the stiffness measurement for blood vessels and plaques such as ultrasound measurements would be important for accurate treatments.
Analysis on the development of Chinese under-forest economy and its effect on the increase of farmers’ income

Abstract As part of the construction of ecological civilization, the development of under-forest economy has been paid more and more attention. This paper uses DEA model to measure the development of under-forest economy. The results show that the development of the under-forest contributes to the increase of the output value, and thus promotes the growth of the farmers’ income.
International Education Issues in Saudi Arabia's Public Education Curricula: An Analytical Study.

The objective of this study is to improve the situation of the general education curriculum in Saudi Arabia, in line with global aspirations in this area and a proposal to implement international education issues in general education curricula. The study was centered on answering the following questions: What is the reality of issues of international education in some of the curricula of the general education schools in Saudi Arabia? What are the most important issues of international education—after identifying and learning from the experiences of countries such as the United States of America and Britain—that can be included in the curricula of public education in Saudi Arabia? The study sample was limited to the Arabic language and Social Studies courses at different levels, namely elementary, middle and high school, which were compared to the general education curricula in the United States and Britain. In light of the experiences found in other countries, the study recommends the integration of the values of international education, such as peace, human rights and multiculturalism, in classrooms and extracurricular activities at all levels of public education in Saudi Arabia. Finally, the study concludes with specifying certain international education issues to be included in each stage of education.
Non-insulin-dependent diabetes: 10-year outcome in relation to initial response to diet and subsequent sulfonylurea therapy.

Thirty-eight non-insulin-dependent diabetic patients within 130% of desirable body weight were given a 100-g oral glucose tolerance test (OGTT) at diagnosis and after at least 1 mo of dietary treatment with energy and carbohydrate restriction. Thirteen "responders" showed an improvement in fasting blood glucose, glucose tolerance, and insulin secretion, with near-normalization of plasma, lactate, pyruvate, free fatty acids, glycerol, and ketone bodies. There were no significant changes in the 25 "non-responders. " The responders were, at diagnosis, heavier than the non-responders (75.5 versus 64.3 kg, P less than 0.01). Twenty non-responders subsequently completed a prospective controlled study of glibenclamide, chlorpropamide, and placebo lasting for 16 mo with OGTTs at the end of each 4-mo treatment phase. The results showed that there were no significant differences between the metabolic effects of glibenclamide and chlorpropamide. On active treatment, insulin levels rose coincident with a fall in fasting blood glucose and an improvement in glucose tolerance and near-normalization of plasma lactate, pyruvate, free fatty acids, glycerol, and ketone bodies, all of which relapsed to initial values after placebo. Ten years after the initial study, 29 of the original patients were traced and reviewed and the outcome related to their earlier tests. Twenty-two percent of the responders and 70% of the non-responders were now on insulin (P less than 0.02); the initial insulin response to OGTT at the end of the diet treatment was significantly lower in those subsequently treated with insulin (P less than 0.01). (ABSTRACT TRUNCATED AT 250 WORDS)