Miracle-dz/UniFAR-FTUs huggingface dataset:
Regulated expression of the Saccharomyces cerevisiae Fre1p/Fre2p Fe/Cu reductase related genes

The Saccharomyces cerevisiae genome contains nine open reading frames (ORFs)—YLR214w (FRE1), YKL220c (FRE2), YOR381w, YNR060w, YOR384w, YLL051c, YOL152w, YGL160w and YLR047c—which, based on amino acid sequence similarity, fall in the category of iron/copper reductase‐related genes. FRE1 and FRE2 are the first identified and studied genes of this family. They both encode for plasma membrane ferric/cupric reductases and their expression is regulated by iron and copper availability, mediated by the transcription factors Aft1p and Mac1p, respectively. We have studied the expression of the seven ORFs of unknown function by monitoring mRNA accumulation under different growth conditions, namely, their response to iron and copper availability in the medium, as well as the involvement of transcription factors Aft1p and Mac1p in their expression. A compilation of these results, together with sequence comparison data, permits a first classification of these genes under three major groups: genes mainly regulated by iron availability, genes mainly regulated by copper availability and genes not regulated by either metal. Copyright © 1999 John Wiley & Sons, Ltd.
Simulated tennis matchplay in a controlled environment

The aim of this study was to develop an exercise protocol to simulate tennis matchplay on a 'category 2' surface. Match analyses were used to form the basis for the design of the protocol. The protocol involved playing against a tennis ball serving machine. Part A of the protocol comprised 92 min 46 s of simulated tennis matchplay; Part B consisted of continuous hitting to the point of 'volitional fatigue' or when the required hitting frequency for two consecutive ball feeds could no longer be maintained. Ten elite tennis players (5 males, 5 females) volunteered to participate in the study, which was performed on an indoor tennis court (Matchplay™, En-Tout-Cas)™. Their age, body mass and estimated maximal oxygen uptake were as follows: males, 21.7±1.0 years, 73.6±2.6 kg and 58.0±1.7 ml · kg−1 · min−1, respectively; females, 21.9±1.3 years, 62.3±2.0 kg and 42.2±0.7 ml · kg · min−1, respectively (mean±). Heart rate, change in body mass and time to volitional fatigue were monitored. The heart rate responses of the participants to the simulated matchplay (range: 140-157 beats · min−1, 73-81% peak heart rate) were consistent with the results of previous studies, for 'actual' matchplay. This protocol was successful in simulating similar physiological responses in Part A to 'actual' matchplay on a 'category 2' surface, in a controlled environment; it was also a sensitive evaluation tool of skilled performance in Part B. The current protocol may be used as a baseline protocol for studying the influence of, for example, training and dietary intervention on performance.
Comparison of ELISA for tissue transglutaminase autoantibodies with antiendomysium antibodies in pediatric and adult patients with celiac disease

Background: Tissue transglutaminase (t‐TG) is the main autoantigen recognized by the endomysium antibodies (EMA) observed in patients with celiac disease (CD). The aim of the study was to assess an ELISA method for t‐TG antibodies (t‐TGA) with respect to EMA IF assay in pediatric and adult patients.
Entrepreneurial orientation, environmental sustainability and new venture performance: Does stakeholder integration matter?

Previous research has theorised that the link between entrepreneurial orientation (EO) and performance is mediated by environmental sustainability orientation (ESO). However, firm‐level factors that may moderate this relationship are lacking. This paper attempts to fill this gap by examining how and when EO enhances new venture performance by considering ESO as mediator and stakeholder integration as an important contingent factor. Using primary data obtained from 242 chief executive officers/entrepreneurs, it was found that the indirect relationship between EO and new venture performance is strengthened at high levels of stakeholder integration. Theoretical and practical implications are discussed.
Stimulant treatment over 5 years: effects on growth.

OBJECTIVE Long-term effects of psychostimulants on growth in height and in weight are investigated in children with attention-deficit/hyperactivity disorder. METHOD Participants were 79 children, 6 to 12 years of age, with attention-deficit/hyperactivity disorder, who were followed annually for up to 5 years, between the years 1993 and 1994 and 1998 and 1999. Annual height and weight measurements were standardized by age and gender using the 2000 Centers for Disease Control and Prevention Growth Charts for the United States and reported as z scores. For children taking stimulants throughout the previous school year, dose potency was standardized to methylphenidate in milligrams per kilogram per day. We used hierarchical linear modeling to investigate the influence of dose and duration of stimulant treatment on the rate of growth in height and weight. RESULTS Controlling for time since initiation of treatment, daily dose of stimulant medication was negatively associated with z scores for height (beta = -.11, SE = 0.03, p <.01) and for weight (beta = -.29, SE = 0.04, p <.01). Estimates based on the statistical model suggest that children receiving > or = 1.5 mg/kg/day methylphenidate will show diminished weight gain after 1 year; those receiving > or = 2.5 mg/kg/day methylphenidate will show diminished gains in height after 4 years. CONCLUSION Long-term use of high doses of stimulants during a period of 1 to 5 years is likely to have measurable effects on the rate of growth in school-age children with attention-deficit/hyperactivity disorder.
Two novel mutations in a purine nucleoside phosphorylase (PNP)‐deficient patient

Purine nucleoside phosphorylase (PNP) deficiency is a rare autosomal recessive disease, which presents clinically as severe combined immunodeficiency (SCID). We report here two novel mutations in the PNP gene that result in SCID phenotype, in a single patient. The maternal‐derived allele carries a C to T transition in exon 2 resulting in a premature stop codon at amino acid 57. The paternal‐derived mutation is a G to A transition at position +1 in intron 3, causing a complete skipping of exon 3 and a reading frameshift at the exon 2–exon 4 junction. The predicted polypeptide encoded by the aberrantly spliced mRNA terminates prematurely after only 89 amino acids. Both mutations predict severely truncated proteins resulting in a complete deficiency of PNP enzymatic activity, yet the development of profound immunodeficiency in this patient is greatly delayed.
Enterprise JavaBeans caching in clustered environments

We present the design of an Enterprise JavaBeans (EJBs) caching architecture, and show that EJB caching can greatly improve application throughput in clustered environments. Throughput is improved because data serving is offloaded from the database server to the cache‐enabled application server. EJB caching is successful because it exploits the low‐latency connections between the database server and application servers that exist in a clustered environment. An important feature of our architecture is that the caching function is transparent to applications that use it. The cache‐enabled application server uses the same (EJB) programming model, and the same transactional semantics, as provided by non‐caching architectures. Copyright © 2005 John Wiley & Sons, Ltd.
Validity of Altman Z-Score Model to Predict Financial Failure: Evidence From Jordan

This paper aims to investigate the Validity of Altman z-score model to predict financial failure in insurance companies listed on Amman Stock Exchange (ASE) over the period 2011-2016. To achieve the goal of the study, the study depended on the different statistics analytical method and Multiple Linear Regression through doing the statistical analysis of the independent variables on the dependent variable related to the subject of the study through the (E-views) program in order to cover the analytical part of the study, in addition to the descriptive method through relying on books, periodicals, previous studies and financial reports of the insurance companies of the study’ sample, whether the direct or the indirect ones, to cover the theoretical part. The result of the study finds a high predictive power for Z-score model. Moreover, the findings reveal that Z-Score model could be valuable instrumental indicators for many users of financial statement such as financial managers, auditors, lenders, investors, to make right decisions in the face of financial failure.
Text messages and romantic relationships: an investigation of mobile communication technologies, attachment processes, and relationship quality.

Mobile technologies have transformed the way that people interact with one another, and manage their friendships and intimate relationships. Text messages of love and support nurture feelings of closeness and connection in romantic relationships and are related to reports of higher relationship quality (Jin & Pena, 2010). More recently, the use of texts to voice criticisms, continue arguments, and create emotional distance has become a focus of research attention (Hertline & Ancheta, 2014). The current program of research explored attachment anxiety and attachment avoidance, text messaging, and texting parameters as predictors of relationship quality in committed adults. Across four studies and a combined sample of 1648 participants, a new technology measure was refined and tested. The Technology Questionnaire (TQ) assessed the extent to which participants turned towards or turned away from relationship partners via text. The TQ also examined texting parameters such as text frequency, response expectations, text targets, and text motives. Associations between texting, relationship satisfaction, intimacy, social and emotional loneliness, destructive conflict, partner care, and partner control were examined. Texting behaviour was considered in the context of romantic attachment, relationship status, and commitment. Principles of sound relationship house theory (SRH; Gottman, 1999) were used with the TQ subscales (Turning Towards and Turning Away) to predict relationship quality and destructive conflict by attachment type. Expressions of positive and negative sentiments via text were related to attachment anxiety, attachment avoidance, relationship quality, and destructive conflict. Results suggest that text communications mirror face-to-face patterns of interpersonal communication, reflecting attachment proclivities and relationship principles known to predict relationship satisfaction and distress. TEXTING AND ROMANTIC QUALITY iii Declaration of Originality This work has not been submitted for a degree or diploma at any university. To my knowledge, the thesis does not contain any material previously published or written by another person, except where due reference is made in the thesis itself. Jodie Nicole Bradnam
Influential factors affecting prognosis of snakebite patients management: Kaohsiung Chang Gung Memorial Hospital experience.

BACKGROUND The objective of this study was to determine the most influential factors affecting the prognosis of snakebite patients in Kaohsiung Chang Gung Memorial Hospital. METHODS A thorough review of the medical records of poisonous snakebite from June 1986 to November 1999 was carried out in this retrospective study. RESULTS Of the identified snakes in 39 bite victims, 70% of these cases were hemorrhagic type: Trimeresurus stejnegeri 20/27, T. mucrosquamatus 6/27, and Agkistrodon acutus 1/27; 28% were neurotoxic type: Naja naja atra 6/11 and Bungarus multicinctus 5/11; and 2% was mixed type: Vipera russelli formosensis 1/39. Three of four acute renal failure victims were bitten by T. mucrosquamatus. Two of the 5 victims bitten by B. multicinctus required endotracheal intubation to maintain their respiration. Five patients received skin grafting, 3 of whom were bitten by Naja naja atra. Most of our patients (55%) received only a single dose of antivenin, and 83% (29/35) of the antivenin was given within 6 hours after the bite; the antivenin infusion was finished in less than 2 hours in most cases (33/36). CONCLUSION Bites from Trimeresurus stejnegeri are the most common poisonous snakebite recorded in our emergency department. T. mucrosquamatus is prominent in causing bleeding tendency and acute renal failure. Bungarus multicinctus is more prominent than Naja naja atra in causing acute respiratory failure. The dosage of antivenin used to treat patient bitten by cobra was less than that recommended by the poison control center, and the complication of skin necrosis requiring skin grafting was more severe than that of the other species.
Sporting Activity and Hyperglycemia in Middle-Aged Men

OBJECTIVE To assess the relationship between self-reported frequency of participation in sporting activity and the prevalence of hyperglycemia (nonfasting glucose level > or = 7.8 mM) in middle-aged men. RESEARCH DESIGN AND METHODS We used a cross-sectional study of 7617 British middle-aged men, drawn from 24 general practices in England, Wales, and Scotland, who were participants in the British Regional Heart Study. The response rate was 78%. Patients with diabetes (physician-diagnosed) were excluded from our analysis. Frequency of participation in sporting activity was determined by the respondents and reported as none (61%), occasionally (12%), or frequently (27%). RESULTS The age-adjusted prevalence odds ratio for hyperglycemia was 0.86 (95% confidence interval, 0.6–1.2) in those reporting occasional, and 0.62 (95% confidence interval, 0.4–0.85) in those reporting frequent sporting activity, compared with those reporting none. This effect of frequent sporting activity on the prevalence of hyperglycemia was independent of body mass index, occupational status, smoking status, systolic blood pressure, use of antihypertensive therapy, and time of sampling. CONCLUSIONS Frequent sporting activity in middle-aged men is associated with a reduced prevalence of hyperglycemia and may reduce the risk of NIDDM.
[Effects of Huaiqihuang granules on immune function in children with severe Mycoplasma pneumoniae pneumonia].

OBJECTIVE To observe the effects of Huaiqihuang granules on the immune function in children with severe Mycoplasma pneumoniae pneumonia. METHODS Pediatric inpatients with severe Mycoplasma pneumoniae pneumonia were randomly divided into Huaiqihuang granule treatment group (n=51) and conventional treatment group (n=47). The Huaiqihuang granule treatment group was orally administered Huaiqihuang granules in addition to the conventional treatment, while the conventional treatment group received conventional treatment only. Levels of serum IgA, IgG, and IgM, percentages of CD4+ and CD8+ T lymphocyte subsets, and CD4+/CD8+ ratio were examined in the two groups. The incidence rate of respiratory tract re-infection within three months following treatment was compared between the two groups. RESULTS The levels of serum IgA, IgG, and IgM, the percentage of CD4+ T lymphocytes, and the CD4+/CD8+ ratio were significantly higher in the Huaiqihuang granule treatment group than in the conventional treatment group three months after treatment (P<0.05). In contrast, the percentage of CD8+ T lymphocytes was significantly lower in the Huaiqihuang granule treatment group than in the conventional treatment group (P<0.05). In addition, the incidence rate of respiratory tract re-infection within three months following treatment was significantly lower in the Huaiqihuang granule treatment group than in the conventional treatment group (P<0.05). CONCLUSIONS Huaiqihuang granules can regulate immune functions and reduce the incidence of short-term respiratory tract re-infection in children with severe Mycoplasma pneumoniae pneumonia.
Si-Ge-Silica Monolithic Integration Platform and Its Application to a 22-Gb/s $\times$ 16-ch WDM Receiver

We describe a Si-Ge-silica monolithic integration platform for telecommunications applications. The monolithic integration process features low-temperature silica film deposition by electron-cyclotron-resonance chemical vapor deposition to prevent thermal damage to Si/Ge active devices. The monolithically integrated Si and SiOx waveguides show propagation losses of 2.8 and 0.9 dB/cm, and the inverse-tapered spot-size converters show a coupling loss of 0.35 dB. We applied the platform to a 22-Gb/s × 16-ch wavelength-division multiplexing receiver, in which a 16-ch SiOx arrayed waveguide grating (AWG) with 1.6-nm channel separation and Ge photodiodes (PDs) are monolithically integrated. The AWG-PD device exhibits fiber-to-PD responsivity of 0.29 A/W and interchannel crosstalk of less than -22 dB and successfully receives 22-Gb/s signal for all 16 channels. In addition, we demonstrate 40-km transmission of 12.5-Gb/s signal and obtain sensitivity of -6.8 dBm at a bit error rate of 10-9 without transimpedance amplifiers.
School Culture's Influence on Beginning Agriculture Teachers' Job Satisfaction and Teacher Self-Efficacy.

This study explored first and second year agriculture teachers’ job satisfaction and teacher selfefficacy through their perceived levels of school culture support. Prior research indicated one possible contributor to poor teacher retention is a lack of belonging teachers feel to their schools. Data were collected from beginning teachers in three states and stepwise multiple regression techniques were used to analyze the data. The researchers found that colleague support was statistically significant contributors to beginning teachers’ efficacy. District and school administration, colleague, and financial supports were all statistically significant contributors to teachers’ job satisfaction. These findings provide support for further research to explore gaps in the profession’s understanding of the role school culture plays for agriculture teachers. Recommendations include incorporating positive relationship-building techniques into pre-service and teacher induction programs and making beginning teachers aware of materials used in promoting agricultural education programs and building administrative relationships.
Effects of magnitude and frequency of variations in external power output on simulated cycling time-trial performance

Abstract Mechanical models of cycling time-trial performance have indicated adverse effects of variations in external power output on overall performance times. Nevertheless, the precise influences of the magnitude and number of these variations over different distances of time trial are unclear. A hypothetical cyclist (body mass 70 kg, bicycle mass 10 kg) was studied using a mathematical model of cycling, which included the effects of acceleration. Performance times were modelled over distances of 4–40 km, mean power outputs of 200–600 W, power variation amplitudes of 5–15% and variation frequencies of 2–32 per time-trial. Effects of a “fast-start” strategy were compared with those of a constant-power strategy. Varying power improved 4-km performance at all power outputs, with the greatest improvement being 0.90 s for ± 15% power variation. For distances of 16.1, 20 and 40 km, varying power by ± 15% increased times by 3.29, 4.46 and 10.43 s respectively, suggesting that in long-duration cycling in constant environmental conditions, cyclists should strive to reduce power variation to maximise performance. The novel finding of the present study is that these effects are augmented with increasing event distance, amplitude and period of variation. These two latter factors reflect a poor adherence to a constant speed.
A Randomized Controlled Trial Assessing the Effect of a Continuous Subcutaneous Infusion of Local Anesthetic Following Elective Surgery to the Great Toe

Local anesthetic use for wound infusions, single injection, and continuous nerve blocks for postoperative analgesia is well established. No study has investigated the effect of a continuous block of the saphenous and superficial peroneal nerves at the level of the ankle joint following first ray surgery. A double blind randomized controlled trial was designed. One hundred patients with hallux valgus and rigidus requiring surgical correction were recruited and randomized to receive a postoperative continuous infusion at the ankle of normal saline or ropivacaine for 24 hours. Pain scores were recorded on postoperative days 1 and 7. There were more females than males. Follow-up was 100%. There were no significant differences in demographic data between the 2 randomized groups. There was no significant difference between the absolute visual analog scale scores on day 1 (P = .14) and day 7 (P = .16); nor was there a significant difference in reduction in scores between days 1 and 7 (P = .70). This study has shown no benefit to postoperative analgesia with the use of a continuous infusion of ropivacaine at the ankle. We, therefore, cannot currently recommend its use in the way described. Further studies may still identify a role for continuous local anesthetic infusions at the ankle to improve postoperative analgesia. Levels of Evidence: Level I : Prospective randomised control trial.
Effects of Enterococcus faecium and dried whey on broiler performance, gut histomorphology and intestinal microbiota

Abstract The experiment was conducted to study the effects of supplementing a broiler starter diet with the probiotic Enterococcus faecium NCIMB 10415 and dried whey (80% lactose) on chick performance, gut histomorphology and intestinal microbiota. One-day-old male Ross 308 strain broiler chickens were fed diets containing: (i) control feed, (ii) control + 3.5% dried whey, (iii) control + 0.2%E. faecium, and (iv) control + 3.5% dried whey + 0.2%E. faecium. Birds were maintained in battery brooders confined in an environmentally controlled experimental room. The experiment lasted for 21 days. Birds fed E. faecium or E. faecium + dried whey exhibited significantly improved weight gain and feed conversion rate (FCR). Weight gain and FCR of treatment groups 1 – 4 were 628.7, 657.8, 690.9, 689.3 and 1.218, 1.193, 1.107, 1.116, respectively. Lactic acid bacteria counts in both the ileal content and excreta were significantly affected by dietary treatment. Supplementation of the E. faecium and dried whey separately and in combination increased lactic acid bacteria colonization in the ileal content from 4.2 to 5.0, 7.8 and to 5.1 log cfu/g, respectively (treatments 1 – 4). Similarly, supplementation of dried whey and E. faecium separately and in combination increased lactic acid bacteria in the excreta from 5.3 to 5.5, 8.0 and to 7.2 log cfu/g, respectively. Addition of the probiotic E. faecium increased villus height in the ileum (p < 0.05). Thus, supplementation of E. faecium enhanced broiler chick performance with respect to weight gain and FCR. No additive effect of E. faecium and dried whey was detected. Further studies are needed to investigate the relationship between E. faecium and dried whey with respect to gut histomorphology.
Computerized Aid Improves Safety Decision Process for Survivors of Intimate Partner Violence

A computerized safety decision aid was developed and tested with Spanish or English-speaking abused women in shelters or domestic violence (DV) support groups (n = 90). The decision aid provides feedback about risk for lethal violence, options for safety, assistance with setting priorities for safety, and a safety plan personalized to the user. Women reported that the decision aid was useful and provided much-needed privacy for making safety decisions. The majority (69%) reported severe to extreme danger in their relationship as scored by Danger Assessment (DA); only 60% reported having made a safety plan. After using the safety decision aid, the women felt more supported in their decision (p = .012) and had less total decisional conflict (p = .014). The study demonstrated that a computerized safety decision aid improved the safety planning process, as demonstrated by reduced decisional conflict after only one use in a sample of abused women.