Miracle-dz/UniFAR-FTUs huggingface dataset:
The heat shock transcription factor 1 as a potential new therapeutic target in multiple myeloma

The heat shock transcription factor 1 (HSF1) has recently been reported to promote malignant transformation and growth. Here we provide experimental evidence for a role of HSF1 in the pathogenesis of multiple myeloma (MM). Immunohistochemical analyses revealed that HSF1 was overexpressed in half of the investigated MM samples, including virtually all cases with extramedullary manifestations or anaplastic morphology. HSF1 function was inhibited either by siRNA‐mediated knockdown or pharmacologically through treatment with triptolide. Both approaches caused depletion of HSF1, lowered the constitutively high expression of a multitude of protective HSPs (such as HSP90, HSP70, HSP40 and HSP27), induced apoptosis in human MM cells in vitro, and strongly reduced MM tumour growth in vivo. Furthermore, we observed that treatment‐induced upregulation of HSPs after proteasome or HSP90 inhibition was critically dependent on HSF1. Importantly, the apoptotic effects of the HSP90 inhibitor NVP‐AUY922 or the proteasome inhibitor bortezomib were strongly enhanced in combination with triptolide, suggesting a salvage role of HSF1‐dependent HSP induction in response to drug treatment. Collectively, our data indicate that inhibition of HSF1 affects multiple protective HSPs and might therefore represent a therapeutic strategy – in particular in combination with proteasome or HSP90 inhibitors.
A randomized study of sodium hypochlorite versus formocresol pulpotomy in primary molar teeth.

BACKGROUND Alternatives to vital pulpotomy treatment in primary teeth are being sought because of the high formaldehyde content of traditional formocresol (FC) pulpotomy medicaments. AIM The aim was to compare the clinical and radiographic success of vital pulpotomy treatment in primary molars using 3% sodium hypochlorite (NaOCl) versus a 1:5 dilution of Buckley's FC. DESIGN Pulpotomies were performed in primary molars of healthy children between 3 and 10 years old. Sixty-five primary teeth were randomized into two groups that were evaluated for treatment outcomes. Following treatment, the pulp chamber was filled with zinc oxide eugenol (ZnOE) and restored with a stainless steel crown cemented with glass ionomer cement. Clinical and radiographic outcomes were recorded at 6 and 12 months. RESULTS The control (FC) and experimental (NaOCl) groups demonstrated 100% clinical success at 6 and 12 months. The NaOCl group had 86% (19/22) radiographic success at 6 months and 80% (12/15) at 12 months. The FC group had 84% (21/25) radiographic success at 6 months and 90% (9/10) at 12 months. No significant differences were found in the radiographic outcomes between the two groups at 6 and 12 months (Fisher's exact test; P=0.574 and P=0.468, respectively). CONCLUSION NaOCl demonstrated clinical and radiographic success comparable to FC.
Mandatory? Voluntary? A Discussion of Corporate Environmental Disclosure Requirements in China

ABSTRACT In the face of an increasing Environmental crisis, the Chinese government has released a series of guidelines and regulations related to corporate environmental disclosure in recent years. However, the distinction between mandatory and voluntary disclosure, when considering China, is still problematic and a clear understanding of what is required by law and what is purely voluntary does not appear to exist in many studies of the region. As most researchers apply a simplistic classification, this leads to confusion and contradictions between studies. This paper outlines the complexities of the regulatory system in China and attempts to provide direction on how the term voluntary disclosure should be used when studying corporate environmental reporting in China.
The diffusion of satellite radio: A study of earlier adopters and non-adopters

The Diffusion of Satellite Radio: A Study of Earlier Adopters and Non-Adopters by Jasmine S. Crighton Dr. Paul Traudt, Examination Committee Chair Associate Professor of Mass Communication University of Nevada, Las Vegas This study examined the current and potential audience of satellite radio by using Roger’s diffusion of innovations theory as a theoretical framework (Rogers, 1962, 1971, 1983, 1995, 2003). Survey research was conducted in June of 2006 to discover adopters’ and non-adopters’ perceptions of satellite radio and competing technologies, their socioeconomic characteristics, demographics, and mass media use. Results of the survey indicated that the average earlier adopters of satellite radio are nearly 32 years of age, earned an average gross annual income of $40,000 to $50,000, and had more formal education than non-subscribers. The average non-adopter of satellite radio was nearly 26 years of age, averaged $20,000 to $30,000 gross annual income, and had some college education. Additionally, satellite radio subscribers more often than non-subscribers owned video game systems, video cameras, and TiVo. Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. TABLE OF CONTENTS ABSTRACT. iii LIST OF FIGURES.vi ACKNOWLEDGEMENTS.vii CHAPTER ONE INTRODUCTION.1 History of Satellite Radio. 1 Technology of Satellite Radio.4 Consumers of Satellite Radio.6 Diffusion of Innovations Theory.10 Criticisms of Diffusion of Innovations.17 Perceived Attributes of Satellite Radio. 21 Summary and Thesis Organization. 23 CHAPTER TWO LITERATURE REVIEW. 26 Emerging Technologies Studies.26 Diffusion of Personal Computers. 26 Diffusion of Cable and Digital Television. 27 Diffusion of DVD Home Theater Systems. 36 Diffusion of Mobile and Cellular Phones. 38 Summary and Implications of Literature Review. 42 CHAPTER THREE METHOD.45 Rationale.46 Method.49 Pre-Test Sample. 54 Survey Pre-Test. 54 Sampling Method for Full Scale Study. 55 Analysis Plan.56 CHAPTER FOUR RESULTS.58 Overview: Respondent Characteristics. 58 Analysis.60 CHAPTER FIVE DISCUSSION.66 General Discussion. 66 Subscribers’ Perceived Attributes.70 Non-Subscribers’ Perceived Attributes. 71
Assessment of Educational Service Quality Gap: The Students’ Perspectives

Background: Noonecandenytheimportanceof educationalservicesandtheroleitplaysinattainingsocialgoals. Propertraining and students’ satisfaction leads to system promotion and ﬁnally social development. This study aimed to evaluate the educational service quality in Qazvin University of Medical Sciences (QUMS). Methods: Thiscross-sectionalstudywasconductedin2014among327studentsofQUMSwhowereselectedthroughsimplerandom sampling. The most signiﬁcant variables were tangibility, assurance, empathy, reliability, and accountability of the educational service quality. The data were collected using the 27 - item SERVQUAL questionnaire. Cronbach’s alpha score ( α = 0.88) and test retest (R = 0.83) method were used to determine the reliability of the questionnaire. Results: Theaverageageof thestudentswas22.2 ± 3.1years. Thequalitygapof theeducationalserviceswas-1.62,-1.70,-1.52,-1.31,and-1.15forassurance,accountability,empathy,reliability,andtangibility,respectively,whichwasstatisticallysigniﬁcant(P< 0.001). The meaneducationalservicequalitygapwas-1.38basedonthestudents’ perceptions(P< 0.001). Therewasnosigniﬁcantrelationship between the students’ perceptions and expectations and their gender (P > 0.05). Conclusions: There are signiﬁcant gaps in the educational service quality regarding accountability and assurance. More attention from policymakers seems to improve the educational service quality.
Feasibility of EEG Measures in Conjunction With Light Exercise for Return-to-Play Evaluation After Sports-Related Concussion

Current clinical assessment of sports-related concussion and the determination of “Return-to-Play” lacks assessment of the pathophysiological processes affecting the concussed brain. The objective of this study was to demonstrate the feasibility of electroencephalogram measures that detect neuronal damage and monitor the healing process, giving an improved approximation of pathophysiological recovery.
Does lack of job satisfaction intensify psychological distress among clinicians, and vice versa?

Background:To analyze prevalence of job dissatisfaction and psychological distress among doctors with exposure of significant socio-demographic aggravators.Material and Methods:This descriptive KAP-survey was conducted under the auspices of Pak Emirates Hospital Rawalpindi from Sep 2017-Apr 2018. Information was collected on a self-designed questionnaire, standardized General Health Questionnaire-12 (GHQ-12) and Job Satisfaction Survey (JSS). Data analyzed via SPSS-21 and p-value (p<0.05 considered significant). Results:Distress and job satisfaction scores were 12.31±6.33(0-30) and 127.28±29.432(36-201) respectively; with a significant positive correlation of job satisfaction with age (0.288 & <0.001), negative correlation of distress with age (-0.177 & 0.008) and job satisfaction (-0.355 & <0.001). Distress was harbored by 20(74.1%), 40(55.6%) and 12(16.7%) of dissatisfied, indecisive or satisfied participants respectively. Age, marital status, total offspring, job description, working schedules, salaries and work experience significantly affected outcome variables; gender and qualification remained inert. Respondents satisfied with job were less distressed than ambivalent (cOR 0.120; 95% CI, 0.047-0.304) or dissatisfied (cOR 0.168; 95% CI, 0.056-0.506). Conclusion:Perpetual relation between job dissatisfaction and psychological distress was confirmed. All echelons of health care providers must be intermittently screened and managed for psychosomatic perils; every aggravator must also be quarried and catered-for.
Axonal transport and MR imaging: Prospects for contrast agent development

Axonal transport plays a critical role in the physiology and pathology of neurons, yet there have been virtually no clinical tools for its evaluation in human subjects. A wide variety of molecules that can act as axonal transport facilitators have been discovered and, in many cases, used to deliver labels detectable with histologic methods. Recently a number of investigators have reported preliminary success in developing intraneural contrast agents based on various versions of dextran‐coated magnetite that may render magnetic resonance imaging capable of depicting axonal transport. It is not yet clear whether any clinically useful agents will eventually be developed, but there has been considerable progress in identifying design factors for such a pharmaceutical agent.
The Impact of Fairness on Service Recovery to BRI Bank Customers Satisfaction and Loyalty on Pemalang Branch of Central Java

The population used in this study is all customers of Bank BRI Branch Pemalang who do complaints. While this sample was 150 customers were considered to have been adequately represent the population studied. The sampling technique used purposive sampling method that is the customers who never make a complaint at Bank BRI. Analysis model used in this research is descriptive analysis, multiple linear regression analysis and simple linear regression analysis. The study found that 1) there is a positive and significant effect on the variable procedural fairness to the satisfaction of the recovery, 2) there is a positive and significant effect on the variable distributive fairness to the satisfaction of recovery 3) there is a positive and significant effect on the variable fairness interaction to the satisfaction of the recovery and 4) There is a positive and significant effect on the variable satisfaction on customer loyalty BRI Bank Branch Pemalang. The implication of this research is recommended to Bank BRI Branch Pemalang to pay attention to fairness in service recovery both procedural fairness, distributive fairness and interactional fairness to increase the satisfaction of the recovery so expect customer loyalty will increase, especially in providing the right solution in the handling of a complaint. Keywords: procedural fairness, distributive fairness, interactional fairness, loyalty
Common pathways in idiopathic pulmonary fibrosis and cancer

Idiopathic pulmonary fibrosis (IPF) is marked by a very disappointing survival rate and still represents a clinical dilemma. According to the current pathogenic hypothesis, chronic damage of the alveolar epithelium is followed by abnormal tissue repair and impairment of the alveolar structure. This process is driven by pathogenic events very similar to cancer, including epigenetic and genetic changes, altered response to regulatory signals, abnormal expression of microRNAs and activation of specific signalling pathways. IPF also resembles cancer with regard to its poor response to medical treatment and prognosis, which is very often worse than many cancers. We have hypothesised that IPF might be assimilated to a neoproliferative disorder of the lung. Viewing IPF as a cancer-like disease may satisfy the need for a better understanding of the pathogenesis of IPF by exploiting the large amount of knowledge that cancer biology evokes. The recognition of common pathogenic pathways between the two diseases may stimulate new clinical trials with cancer drugs, different drug combinations and different lines of drugs, as already experimented in oncology. Moreover, the concept of IPF as a cancer-like disorder may improve the attention given to this dreadful disease on a public, political and healthcare level.
Instabilités et sources locales de turbulence dans les disques d'accrétion

Le probleme du transport de moment cinetique dans les disques d'accretion astrophysiques fait l'objet d'un vif debat depuis maintenant une trentaine d'annees. On propose ici une etude de ce transport en considerant plusieurs instabilites pouvant conduire a de la turbulence developpee dans les disques. La premiere instabilite proposee est l'instabilite hydrodynamique sous critique de cisaillement. Une etude numerique de cette instabilite nous permet de montrer que, bien que non detectable dans les simulations, le transport obtenu sera tres probablement bien trop faible pour expliquer les observations actuelles. Nous etudions ensuite l'instabilite strato-rotationnelle et nous montrons par un developpement analytique que les contraintes sur les conditions aux limites empechent la formation de cette instabilite dans un vrai disque. Enfin, nous nous interessons a l'instabilite magneto-rotationnelle en presence d'effets non ideaux (viscosite et resistivite magnetique). Nous montrons alors que ces effets non ideaux, bien que faibles a priori, ont un fort impact sur l'efficacite de la turbulence finalement engendree. Ce dernier point montre le role que peut avoir la microphysique dans le processus de saturation, et la necessite d'avoir une modelisation de ces effets afin d'obtenir un modele de transport coherent dans les disques d'accretion.
Police Violence and Its Public Support

The paper analyzes two models of social support for totalitarian social movements, the mass society model, and the class conflict or interest group model. Using national sur vey data, the authors formulate and test the implications of each of these models in terms of generating support for police vio lence among the mass public. With the exception of a positive relationship between education and rejection of police violence, the mass society model is not well supported by the data exam ined by the authors. Generally strong support is present for the class conflict model.
Do Firms Purposefully Change Capital Structure?: Evidence from a Growth Shock to Pharmaceutical Firms

Do firms make significant changes to capital structures over time? We use the passage of the Biologics Price Competition and Innovation Act as a shock to pharmaceutical firms' growth prospects, and study their subsequent capital structure changes. The biosimilar-opportunity led pharmaceutical firms to make their debt structures less constraining. Using a difference-in-difference approach, we show that pharmaceutical firms increased unsecured debt, shortened debt maturity, and reduced convertible debt. Additionally, new debt covenants were not more restrictive than old debt covenants, and leverage decreased for firms with high initial leverage. Results support the view that firms actively manage their debt structure.
Drivers of service climate: an emerging market perspective

Purpose Drawing on social exchange theory, the purpose of this paper is to develop and test an integrative model of internal and external factors determining employee perceptions of their organizational service climate. Design/methodology/approach Data are collected from a sample of 549 service employees in local and foreign-owned service firms in the emerging market of Vietnam. Structural equation modeling is used to test the hypothesized relationships. Findings Leadership commitment to service quality, internal processes and service standards, work facilitation resources and service-oriented human resource practices are positively associated with service climate. Internal customer service mediates the effects of these variables on service climate, with the exception of work facilitation resources. Furthermore, competitive intensity negatively moderates the impact of the internal drivers on service climate. The results also suggest that, depending on the ownership types (local vs foreign firms), the influences of the internal drivers of service climate might differ. Originality/value Despite the recognition of the role of organizational resources in fostering service climate, the integration and processes by which such resources influence service climate have not been fully examined. In particular, little is known about the external factors facilitating or hindering service climate, especially from an emerging market perspective. By examining both internal and external drivers of service climate under different ownership types, this paper enriches the existing knowledge on service climate and provides important implications for service firms operating in emerging markets.
Absorptive Capacity and Firms’ Generation of Innovation - Revisiting Zahra and George’s Model

The firm’s absorptive capacity triggers its propensity to capture external knowledge, spurred by internal levers and cooperation liaisons, stimulating innovativeness. This paper revisits Zahra and George’s model of absorptive capacity and others, analysing the firm’s internal and liaison factors that affect its absorptive capacity, in order to predict their influence on innovation. Being the firm an open system, managers acknowledging such effects can design a more efficient open innovation business model in order to generate more innovation. We analyse firm-level internal indicators measuring firm’s absorptive capacity and a set of liaison factors, using a Portuguese sample of 571 service firms and 562 manufacturing firms that participated in the European Community Innovation Survey (CIS), 2010. Results reveal that internal R&D, acquisition of external R&D, acquisition of external knowledge (i.e., equipment, software, licenses and employee training) affect firms' generation of innovation, according to the different sub-samples, which provides several implications for science and innovation policy.
Menguak Realitas Orang Muda Sektor Pertanian Di Perdesaan

It is widely assumed that young people in rural areas are no longer attracted to work in the agricultural sector, especially small scale agriculture. On the other hand, small scale agriculture in Indonesia is still the nation's biggest absorber of labour. In the future, young people's abandonment of agriculture could be a serious threat for social reproduction in the agricultural sector and rural society. Based on that concern, this study analyses young men and women's preference and involvement in farming, and factors that influence it. The research was carried out in 12 villages in 3 provinces with high rice production (West Java, Central Java, and South Sulawesi). This research found that on the one hand, rural youth are not attracted to work in agriculture, but in fact many are still involved in agriculture. Their involvement in farming, generally, is only as family labour and wage worker. For young people who are interested to become farmers, it is almost impossible to get access to farm land while still young. This is one reason why young people decide to migrate. But the decision ‘to farm or not to farm' is not necessarily a decision for life; many of today's farmers have a history of migration, and returned when they had accumulated savings and/or when land became available. For these reasons, the authors do not feel that there will be any serious problem of regeneration of the small-farm sector in the future. One kind of farm work that is attractive for young men and women is rice harvesting. But now rice harvesting is threatened by the introduction of combine harvester technology. This technology can be operated only by 6-7 persons, while manual rice harvesting needs about 30 labourers per hectare. There are many factors that influence young people's preference and involvement in agriculture, namely: access to land, the presence and quality of non farm occupation, young people's image of agriculture and rural life, and educational level.
Testing the Effect of Quality Reports on the Health Plan Choices of Medicare Beneficiaries

This article describes a laboratory experiment that used a convenience sample of 225 Medicare beneficiaries to test the effects of comparative quality information on plan choice. Providing information about quality did not significantly influence the choice between Original Medicare and a health maintenance organization (HMO), but did affect the choice of HMO. Results from this experiment suggest that information about plan quality may not be effective in encouraging beneficiaries to leave Original Medicare and join HMOs that are rated high in quality. Furthermore, beneficiaries choosing among HMOs were not inclined to select a low-cost HMO, even when it was rated higher in quality. Implications for policy are discussed.
TLR-2–Activated B Cells Suppress Helicobacter-Induced Preneoplastic Gastric Immunopathology by Inducing T Regulatory-1 Cells

B cells regulate autoimmune pathologies and chronic inflammatory conditions such as autoimmune encephalomyelitis and inflammatory bowel disease. The potential counterregulatory role of B cells in balancing pathogen-specific immune responses and the associated immunopathology is less well understood owing to the lack of appropriate persistent infection models. In this paper, we show that B cells have the ability to negatively regulate adaptive immune responses to bacterial pathogens. Using mouse models of infection with Helicobacter felis, a close relative of the human gastrointestinal pathogen H. pylori, we found that B cells activated by Helicobacter TLR-2 ligands induce IL-10–producing CD4+CD25+ T regulatory-1 (Tr-1)–like cells in vitro and in vivo. Tr-1 conversion depends on TCR signaling and a direct T-/B-interaction through CD40/CD40L and CD80/CD28. B cell-induced Tr-1 cells acquire suppressive activity in vitro and suppress excessive gastric Helicobacter-associated immunopathology in vivo. Adoptive cotransfer of MyD88-proficient B cells and Tr-1 cells restores a normal gastric mucosal architecture in MyD88−/− and IL-10−/− mice in a manner that depends on T cellular, but not B cellular, IL-10 production. Our findings describe a novel mechanism of B cell-dependent Tr-1 cell generation and function in a clinically relevant disease model. In conclusion, we demonstrate that the B cell/Tr-1 cell axis is essential for balancing the control of Helicobacter infection with the prevention of excessive Th1-driven gastric immunopathology, promoting gastric mucosal homeostasis on the one hand and facilitating Helicobacter persistence on the other.