Miracle-dz/UniFAR-FTUs huggingface dataset:
Low Cost and High Efficiency Hybrid Architecture Massive MIMO Systems Based on DFT Processing

Low cost and high efficiency, defined as energy efficiency (EE) and spectral efficiency (SE), have raised more and more attention in the fifth generation (5G) communication systems due to steadily rising hardware cost, energy consumption, and mobile traffic. This paper studies the hybrid architecture of multiuser massive MIMO systems, where the digital domain utilizes the zero-forcing (ZF) precoding scheme and the analog domain uses discrete Fourier transform (DFT) processing that significantly reduces hardware cost and energy consumption. We derive analytical expressions on the total achievable SE and EE, as well as offering insight into some engineering parameters in the system performance. Our aim is to achieve low cost and high efficiency massive MIMO system, with constraints on the overall transmit power, the number of users, and the number of radio frequency (RF) chains. Results exhibit that the total achievable SE of the hybrid architectures with DFT precessing is inferior to the full digital architectures and hybrid architectures with the ideal phase shifters, but the performance attenuation can be compensated by providing the more input SNR and higher number of RF chains. Moreover, we find that the total achievable EE of hybrid architectures with DFT precessing outperforms other massive MIMO architectures that include a full digital implementation, ideal phase shifters, and a switched network.
Social network analysis: An overview

Social network analysis (SNA) is a core pursuit of analyzing social networks today. In addition to the usual statistical techniques of data analysis, these networks are investigated using SNA measures. It helps in understanding the dependencies between social entities in the data, characterizing their behaviors and their effect on the network as a whole and over time. Therefore, this article attempts to provide a succinct overview of SNA in diverse topological networks (static, temporal, and evolving networks) and perspective (ego‐networks). As one of the primary applicability of SNA is in networked data mining, we provide a brief overview of network mining models as well; by this, we present the readers with a concise guided tour from analysis to mining of networks.
The First Decade of Web-Based Sports Injury Surveillance: Descriptive Epidemiology of Injuries in United States High School Football (2005-2006 Through 2013-2014) and National Collegiate Athletic Association Football (2004-2005 Through 2013-2014).

CONTEXT: The advent of Web-based sports injury surveillance via programs such as the High School Reporting Information Online system and the National Collegiate Athletic Association Injury Surveillance Program has aided the acquisition of football injury data. OBJECTIVE: To describe the epidemiology of injuries sustained in high school football in the 2005-2006 through 2013-2014 academic years and collegiate football in the 2004-2005 through 2013-2014 academic years using Web-based sports injury surveillance. DESIGN: Descriptive epidemiology study. SETTING: Online injury surveillance from football teams of high school boys (annual average = 100) and collegiate men (annual average = 43). PATIENTS OR OTHER PARTICIPANTS: Football players who participated in practices and competitions during the 2005-2006 through 2013-2014 academic years in high school or the 2004-2005 through 2013-2014 academic years in college. MAIN OUTCOME MEASURE(S): Athletic trainers collected time-loss injury (≥24 hours) and exposure data. Injury rates per 1000 athlete-exposures (AEs), injury rate ratios (IRRs) with 95% confidence intervals (CIs), and injury proportions by body site and diagnosis were calculated. RESULTS: The High School Reporting Information Online system documented 18 189 time-loss injuries during 4 539 636 AEs; the National Collegiate Athletic Association Injury Surveillance Program documented 22 766 time-loss injuries during 3 121 476 AEs. The injury rate was higher among collegiate than high school (7.29 versus 4.01/1000 AEs; IRR = 1.82; 95% CI = 1.79, 1.86) athletes. Most injuries occurred during competitions in high school (53.2%) and practices in college (60.9%). The competition injury rate was higher than the practice injury rate among both high school (IRR = 5.62; 95% CI = 5.46, 5.78) and collegiate (IRR = 6.59; 95% CI = 6.41, 6.76) players. Most injuries at both levels affected the lower extremity and the shoulder/clavicle and were diagnosed as ligament sprains and muscle/tendon strains. However, concussion was a common injury during competitions among most positions. CONCLUSIONS: Injury rates were higher in college than in high school and higher for competitions than for practices. Concussion was a frequent injury sustained during competitions, which confirms the need to develop interventions to mitigate its incidence and severity.
Influence des procédés de tonnellerie et des conditions d'élevage sur la composition et la qualité des vins élevés en fûts de chêne

L'elevage des vins en futs de chene peut modifier la composition chimique et les caracteristiques organoleptique des vins. Les differentes especes de chenes europeens (Quercus sessilis et Quercus robur), ou americaines (Quercus alba), qui sont utilisees en tonnellerie possedent une composition physico-chimique assez differente. Aux differences d'ordre botanique s'ajoute en Europe une variabilite geographique importante. Le sechage naturel entraine une modification de la composition et de la qualite du bois de chene. Les mecanismes chimiques et biochimiques de ces transformations sont discutes. Pendant la fabrication des barriques, les operations de chauffe representent une etape susceptible de modifier a nouveau les caracteristiques physico-chimiques du bois. Le choix de l'origine et de l'intensite de brulage du bois permet d'adapter l'impact aromatique du fut au type de vins. La mise au point d'un systeme de chauffe regulee automatique produit un brulage extremement proche de celui obtenu avec la chauffe traditionnelle ; sa reproductibilite est meilleure en raison de la stabilite de la source thermique utilisee. Pendant l'elevage des vins rouges en barriques, la composition du vin en substances volatiles et odorantes, notamment en phenols volatils, est profondement modifiee. Nous montrons que l'enrichissement excessif des vins en ethyl-4-phenol et en ethyl-4-gaiacol peut etre responsable d'un defaut olfactif evoquant l'odeur de "sueur de cheval" que nous avons qualifie de "caractere phenole" des vins rouges. Ces substances sont issues de levures de contamination appartenant au genre Brettanomyces/Dekkera se developpant a partir de traces de sucres residuels. La maitrise des conditions d'elevage, et des methodes de sulfitage en particulier, permet de prevenir le developpement de ces micro-organismes et d'assurer le maintien de la typicite aromatique des vins eleves en barriques.
Childhood Cancer in Basrah, Iraq During 2012-2016: Incidence and Mortality

Background: Worldwide, childhood cancer is rare. In addition, a distinct variation in both incidence and type distribution was reported between countries. Aim: To estimate the incidence and mortality rates of childhood cancer in Basrah, Iraq during 2012-2016. Methods: This registry based descriptive study included children aged 0-14 years with primary cancer who were newly diagnosed in Basrah during 2012-2016. The types of malignant tumors were classified according to International Classification of Childhood Cancer, Version 3 (ICCC-3). The overall and specific incidence and mortality rates by age and sex were calculated per 100,000 population. Results: A total of 723 new cases of childhood cancer were registered during the five- year study period, with a male to-female ratio of 1.2/1. Children aged <4 years accounted for 43.1% of patients. The overall incidence rate was 13.74/100,000, and the age standardized incidence rate (ASIR) was 13.87/100,000. Boys showed higher incidence rate than girls (14.78 vs. 12.66/100,000). Leukemia was the most common type of childhood cancer accounting for 35.4%, followed by lymphoma (17.8%), and central nervous system tumors 11.9%. The overall cancer-specific mortality rate was 6.04/100,000 and the ASMR was 6.08/100,000 children. Conclusion: The incidence rate of childhood cancer in Basrah as well as the cancer type distribution was comparable to that reported for developing countries.
First‐line therapy for post‐traumatic stress disorder: A systematic review of cognitive behavioural therapy and psychodynamic approaches

Abstract Background Despite evidence supporting cognitive behavioural therapy (CBT)‐based interventions as the most effective approach for treating post‐traumatic stress disorder (PTSD) in randomised control trials, alternative treatment interventions are often used in clinical practice. Psychodynamic (PDT)‐based interventions are one example of such preferred approaches, this is despite comparatively limited available evidence supporting their effectiveness for treating PTSD. Aims Existing research exploring effective therapeutic interventions for PTSD includes trauma‐focused CBT involving exposure techniques. The present review sought to establish the treatment efficacy of CBT and PDT approaches and considers the potential impact of selecting PDT‐based techniques over CBT‐based techniques for the treatment of PTSD. Results The evidence reviewed provided examples supporting PDT‐based therapy as an effective treatment for PTSD, but confirmed CBT as more effective in the treatment of this particular disorder. Comparable dropout rates were reported for both treatment approaches, suggesting that relative dropout rate should not be a pivotal factor in the selection of a PDT approach over CBT for treatment of PTSD. Conclusion/Implications The need to routinely observe evidence‐based recommendations for effective treatment of PTSD is highlighted and factors undermining practitioner engagement with CBT‐based interventions for the treatment of PTSD are identified.
Risk of intracranial hemorrhage (RICH) in users of oral antithrombotic drugs: Nationwide pharmacoepidemiological study

Background The risks of intracranial haemorrhage (ICH) associated with antithrombotic drugs outside clinical trials are gaining increased attention. The aim of this nationwide study was to investigate the risk of ICH requiring hospital admission in users of antithrombotic drugs. Methods and findings Data from the Norwegian Patient Registry and Norwegian Prescription Database were linked on an individual level. The primary outcome was incidence rates of ICH associated with use of antithrombotic drugs. Secondary endpoints were risk of ICH and fatal outcome following ICH assessed by Cox models. Among 3,131,270 individuals ≥18 years old observed from 2008 through 2014, there were 729,818 users of antithrombotic medications and 22,111 ICH hospitalizations. Annual crude ICH rates per 100 person-years were 0.076 (95% CI, 0.075–0.077) in non-users and 0.30 (95% CI, 0.30–0.31) in users of antithrombotic medication, with the highest age and sex adjusted rates observed for aspirin-dipyridamole plus clopidogrel (0.44; 95% CI, 0.19–0.69), rivaroxaban plus aspirin (0.36; 95% CI, 0.16–0.56), warfarin plus aspirin (0.34; 95% CI, 0.26–0.43), and warfarin plus aspirin and clopidogrel (0.33; 95% CI, 0.073–0.60). With no antithrombotic medication as reference, the highest adjusted hazard ratios (HR) for ICH were observed for aspirin-dypiridamole plus clopidogrel (6.29; 95% CI 3.71–10.7), warfarin plus aspirin and clopidogrel (4.38; 95% CI 2.71–7.09), rivaroxaban plus aspirin (3.82; 95% CI, 2.46–5.95), and warfarin plus aspirin (3.40; 95% CI, 2.99–3.86). All antithrombotic medication regimens were associated with an increased risk of ICH, except dabigatran monotherapy (HR 1.20; 95% CI, 0.88–1.65) and dabigatran plus aspirin (HR 1.79; 95% CI, 0.96–3.34). Fatal outcome within 90 days was more common in users (2,603 of 8,055) than non-users (3,228 of 14,056) of antithrombotic medication (32.3% vs 23.0%, p<0.001), and was associated with use of warfarin plus aspirin and clopidogrel (HR 2.89; 95% CI, 1.49–5.60), warfarin plus aspirin (HR 1.37; 95% CI, 1.11–1.68), aspirin plus clopidogrel (HR 1.30; 95% CI, 1.05–1.61), and warfarin (HR 1.19; 95% CI, 1.09–1.31). Increased one-year mortality was observed in users of antithrombotic medication following hemorrhagic stroke, subdural hemorrhage, subarachnoid hemorrhage, and traumatic ICH (all p<0.001). Limitations include those inherent to observational studies including the inability to make causal inferences, certain assumptions regarding drug exposure, and the possibility of residual confounding. Conclusions The real-world incidence rates and risks of ICH were generally higher than reported in randomized controlled trials. There is still major room for improvement in terms of antithrombotic medication safety (clinicaltrials.gov NCT02481011).
Exploring Interactivity and Co-Creation in Rural China

Fundamental Research Funds for the Central Universities, China (2015BAH22F00), and Chinese Science and Technology Research Program (K1306027-11), Markor Furnishings’ donation, The Engineering and Physical Sciences Research Council (EPSRC) grants EP/J017205/1 and EP/K009559/1 and Georgia Tech Faculty Development Grant (4901326).
Variations in drug-related problems detected by multidisciplinary teams in Norwegian nursing homes and home nursing care

Abstract Objective: Traditionally, nursing homes have been associated with suboptimal drug therapy and drug-related problems (DRPs). In contrast, less is known about drug safety in homecare. The aim of this study was to describe and compare DRPs in older persons across two care settings: nursing homes and home nursing care. Design: Cross-sectional study using descriptive and inferential statistics. Setting: Nursing homes (n = 5) and home nursing care units (n = 8) across nine municipalities in the middle of Norway. Participants: Multidisciplinary medication reviews for 61 nursing home residents and 93 patients receiving home nursing care performed over the 2013–2014 period, were mapped and examined (N = 154). Main outcome measures: DRPs classified by a Norwegian Classification Tool. Results: In all, 740 DRPs were detected in the total sample, 227 in nursing homes and 513 in home nursing care. DRPs were significantly higher among patients receiving home-based care (Mean =5.5) compared to patients in nursing homes (Mean =3.7, p = 0.002). Among the problem categories, the need for additional drug was most frequent in nursing homes (p = 0.001), while documentation discrepancies reached the highest numbers in patients receiving home nursing care (p = 0.000). Additionally, patients in home nursing care had more problems concerning adverse reactions (p = 0.060); however, this was not statistically significant. Differences in DRP categories leading to changes in the patients’ medication lists were also discovered. Conclusions: The frequency of unclear documentation and adverse reactions found in the homecare setting is alarming. This is an important issue given the trend in aged care towards caring people in their own homes. Further research is warranted to explore how different care settings may influence the safety of pharmacotherapy for older persons. Key Points Drug related problems are a significant cause of concern among patients receiving home nursing care as well as for patients living in nursing homes. The findings of this study showed that: •Significantly more DRPs were detected among patients receiving home nursing care than patients living in nursing homes. •While patients living in nursing homes were often undermedicated, documentation discrepancies were more frequent in home nursing care. •DRP categories leading to changes on the medication lists differed between the settings.
Idiopathic pulmonary arterial hypertension – a unrecognized cause of high‐shear high‐flow haemostatic defects (otherwise referred to as acquired von Willebrand syndrome) in children

Acquired von Willebrand syndrome (AVWS) is reported in high‐flow high‐shear congenital cardiac disorders. We hypothesized that the narrowed pulmonary vasculature in idiopathic pulmonary arterial hypertension (IPAH) may induce AVWS. We conducted a cross‐sectional evaluation of children with IPAH. Patients with bleeding symptoms and/or laboratory abnormalities (thrombocytopenia, anomalies in coagulation screening tests) were tested in‐depth for haemostatic defects. Fourteen children were followed with IPAH of which 8 were eligible. Four children exhibited abnormal bleeding scores (International Society on Thrombosis and Haemostasis Bleeding Assessment Tool: 3–5). All 8 patients showed very prolonged platelet function analyser (PFA)‐100 closure times. Six children demonstrated either mild thrombocytopenia or low‐normal von Willebrand factor (VWF) antigen (VWF:Ag) or VWF activity [mean (range), in iu/dl: VWF:Ag: 70 (61–91); VWF activity: 57 (34–70)]. Average VWF collagen binding capacity (VWF:CB) was 64 iu/dl (range: 53–123 iu/dl), with low‐normal VWF activity/VWF:Ag or VWF:CB/VWF:Ag ratios occurring in five patients. All children had normal multimers distribution patterns. One patient underwent a lung transplantation, with normalization of haemostatic abnormalities post‐surgery. Overall, 8 out of 14 children with IPAH had mild to moderate bleeding symptoms and/or laboratory abnormalities in keeping with AVWS. Normalization of the haemostatic defects following lung transplantation and lack of family history of bleeding attests to the acquired nature of their defects.
Mindfulness' effects on stress, coping, and mood: A daily diary goodness-of-fit study.

Dispositional mindfulness is often linked to higher positive affect and lower negative affect, and coping with stress has been hypothesized to mediate these links. However, few studies have explicitly tested the ways in which stress appraisals, coping strategies, or coping flexibility (i.e., fit of coping to controllability appraisals) uniquely relate to mindfulness and well-being. Drawing on a stress and coping framework, the present study tested the degree to which (a) lower stress appraisals mediate mindfulness' effects on daily positive and negative affect; (b) daily coping mediates mindfulness' impact on daily positive and negative affect, above and beyond the effects of stress appraisals; and (c) coping flexibility mediates mindfulness' impact on positive and negative affect, above and beyond the effects of stress appraisals and average daily coping. Participants were 157 undergraduate students (mean age = 17.81; 79% women), completing daily diary questionnaires regarding stress appraisals, coping, and affect for 1 week. Results demonstrate that lower average stress appraisals mediated 19% of mindfulness' effects on negative affect; further, average use of some "mindful" emotion-focused coping strategies (i.e., non-self-blame and acceptance) independently mediated 3%-13% of mindfulness' effects on positive and negative affect. Although mindfulness was associated with greater "fit" of problem-focused versus acceptance coping to high controllability appraisals, coping flexibility did not appear to mediate mindfulness' effects on either positive or negative affect. Thus, mindfulness-based stress management interventions may be most effective by promoting mindful coping to complement, rather than replace, problem-focused coping. (PsycINFO Database Record
Yield of Low-Dose Computerized Tomography Screening for Lung Cancer in High-Risk Workers: The Case of 7189 US Nuclear Weapons Workers

Objectives To determine the lung cancer screening yield and stages in a union-sponsored low-dose computerized tomography scan program for nuclear weapons workers with diverse ages, smoking histories, and occupations. Methods We implemented a low-dose computerized tomography program among 7189 nuclear weapons workers in 9 nonmetropolitan US communities during 2000 to 2013. Eligibility criteria included age, smoking, occupation, radiographic asbestos-related fibrosis, and a positive beryllium lymphocyte proliferation test. Results The proportion with screen-detected lung cancer among smokers aged 50 years or older was 0.83% at baseline and 0.51% on annual scan. Of 80 lung cancers, 59% (n = 47) were stage I, and 10% (n = 8) were stage II. Screening yields of study subpopulations who met the National Lung Screening Trial or the National Comprehensive Cancer Network Group 2 eligibility criteria were similar to those found in the National Lung Screening Trial. Conclusions Computerized tomography screening for lung cancer among high-risk workers leads to a favorable yield of early-stage lung cancers. Public Health Implications Health equity and efficiency dictate that screening high-risk workers for lung cancer should be an important public health priority.
Activation of the Calcium-Sensing Receptor Corrects the Impaired Mitochondrial Energy Status Observed in Renal Polycystin-1 Knockdown Cells Modeling Autosomal Dominant Polycystic Kidney Disease

Autosomal Dominant Polycistic kidney Disease (ADPKD) is a renal channelopathy due to loss-of-function mutations in the PKD1 or PKD2 genes, encoding polycystin-1 (PC1) or polycystin-2 (PC2), respectively. PC1 is a large protein found predominantly on the plasma membrane where interacts with different proteins, including PC2. PC2 is a smaller integral membrane protein also expressed in intracellular organelles, acting as a non-selective cation channel permeable to calcium. Both PC1 and PC2 are also localized to the primary cilium of renal epithelial cells serving as mechanosensor that controls calcium influx through the plasma membrane and regulates intracellular calcium release from the endoplasmic reticulum. The mechanisms by which PC1/2 dysfunction leads to ADPKD needs still to be clarified. We have recently reported that selective Calcium-Sensing Receptor (CaSR) activation in human conditionally immortalized Proximal Tubular Epithelial cells deficient for PC1 (ciPTEC-PC1KD), deriving from urine sediments reduces intracellular cAMP and mTOR activity, and increases intracellular calcium reversing the principal ADPKD dysregulations. Reduced cellular free calcium found in ADPKD can, on the other hand, affect mitochondrial function and ATP production and, interestingly, a relationship between mitochondria and renal polycystic diseases have been suggested. By using ciPTEC-PC1KD as experimental tool modeling of ADPKD, we show here that, compared with wild type cells, ciPTEC-PC1KD have significantly lower mitochondrial calcium levels associated with a severe deficit in mitochondrial ATP production, secondary to a multilevel impairment of oxidative phosphorylation. Notably, selective CaSR activation with the calcimimetic NPS-R568 increases mitochondrial calcium content close to the levels found in resting wild type cells, and fully recovers the cell energy deficit associated to the PC1 channel disruption. Treatment of ciPTEC-PC1KD with 2-APB, an IP3R inhibitor, prevented the rescue of bioenergetics deficit induced by CaSR activation supporting a critical role of IP3Rs in driving ER-to-mitochondria Ca2+ shuttle. Together these data indicate that, besides reversing the principal dysregulations considered the most proximal events in ADPKD pathogenesis, selective CaSR activation in PKD1 deficient cells restores altered mitochondrial function that, in ADPKD, is known to facilitate cyst formation. These findings identify CaSR as a potential therapeutic target.