Miracle-dz/UniFAR-FTUs huggingface dataset:
Analyzing financial distress of listed companies using neural network

Corporation financial distress has been an important issue for study in the financial fields. This paper uses traditional BP neural network model and proposes PNN model to predicate financial distress. The sample consists of 276 companies listed on the Shanghai Stock Exchange and Shenzhen Stock Exchange over the period 2001-2010. Factor analysis is used to lower correlation and reduce dimensionality. The results demonstrate that the PNN model has higher explanatory power in predicating financial distress than BPN model.
Transient PKC&agr; shuttling to the immunological synapse is governed by DGK&zgr; and regulates L-selectin shedding

Summary Considerable evidence indicates that diacylglycerol (DAG) generation at the immunological synapse (IS) determines T cell functions by regulating the duration and amplitude of Ras/ERK signals. The exact mechanism by which DAG regulates Ras/ERK activation downstream of the T cell receptor (TCR) nonetheless remains poorly understood. Here we characterize PKC&agr; as a previously unrecognized component of the machinery that translates cell receptor occupancy into Ras/ERK-propagated signals. We show transient translocation of PKC&agr; to the IS, mediated by DAG generation at the contact area. Diacylglycerol kinase (DGK)&zgr; negatively regulated PKC&agr; translocation kinetics, whereas PKC&agr; activity limited its own persistence at the IS. Coordinated activation of DGK&zgr; and PKC&agr; in response to antigen recognition regulated the amplitude and duration of Ras/ERK activation; this in turn mediated early processes of T cell surface proteolysis such as L-selectin shedding. Analysis of DGK&zgr;-deficient mice further showed that increased DAG signaling is translated to downstream elements of this pathway, as reflected by enhanced PKC&agr;-dependent L-selectin shedding. We propose that early activation of a DAG–PKC&agr; axis contributes to the mechanisms by which antigen affinity translates into TCR biological responses.
4-[(5-Bromo-2-hydroxybenzylidene)amino]-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide–4-bromo-2-[(E)-({4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenyl}iminio)methyl]phenolate [0.61 (7)/0.39 (7)]

The title compound, 0.61C19H17BrN4O3S·0.39C19H17BrN4O3S, is a Schiff base derived from 5-bromosalicylaldehyde and 4-amino-N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide(sulfamethazine) and is isostructural with its chloro analogue. The geometry of the title molecule points to the enol (OH—C=C—C=N) form as the major tautomer, however two electron-density maxima corresponding to the H atoms of the OH and NH groups, found in the region of a strong intramolecular N⋯H⋯O hydrogen bond, do not allow the elimination of the presence of the zwitterionic (O−—C=C—C=NH+) form in the crystal. Refinement of the occupancies of these H atoms gave a 0.61 (7):0.39 (7) ratio of the enolic and zwitterionic forms. The two benzene rings within the molecule are nearly coplanar and the central benzene ring forms a dihedral angle of 84.1 (1)° with the pyrimidine fragment. An intermolecular N—H⋯O hydrogen bond links molecules into chains extended along the a axis and a C—H⋯O link is also present. The H atoms of one of the methyl groups are disordered over two sites with an occupancy ratio of 0.72 (7):0.28 (7).
Differences in Erythrocyte Index and Hyporesponsiveness to Erythropoiesis in Hemodialysis Patients Treated with Different Erythropoiesis-Stimulating Agents

The majority of patients undergoing hemodialysis have anemia due to decreased production of erythropoietin. This condition is referred to as renal anemia, and is a type of normocytic and normochromic anemia. Renal anemia contributes to a worsening of quality of life (QOL) and has a poor prognosis for survival. Clinical use of erythropoiesis-stimulating agents (ESAs) has markedly improved the QOL and prognosis for survival of hemodialysis patients. ESA is commonly used for treatment of renal anemia, but some hemodialysis patients subsequently develop macrocytic and hypochromic anemia that is not responsive to vitamin B12 and folic acids (Ogura et al., 2007). Macrocytic and hypochromic anemia after ESA treatment is also common in elderly hemodialysis patients (Murata, 1998). However, the mechanism underlying ESA induction of these changes in erythropoiesis is unknown. The correlation between renal anemia and ischemic heart disease, which is referred to as cardiorenal anemia syndrome (CARS) (Silverberg, 2003), suggests that treatment of anemia may also suppress cardiovascular events. However, the results of the Correction of Hemoglobin and Outcome in Renal Insufficiency (CHOIR) study showed that patients with a high hemoglobin level in stage III-IV chronic kidney disease (CKD) after use of large doses of ESA have a poor prognosis for cardiovascular complications (Singh et al., 2006). Also, in a meta-analysis, Phrommintikul et al. reported an increased incidence of cerebrovascular disease in patients treated with ESAs at a high dose, with the incidence not related to the hemoglobin value (Phrommintikul et al., 2007). Recently, the results of a randomized control study (Trial to Reduce cardiovascular Events with Aranesp Therapy: TREAT) in diabetic CKD patients showed that darbepoetin did not have an inhibitory effect on the progression of renal dysfunction and the new onset of cardiovascular events (Pfeffer et al., 2009). Based on the results of the TREAT trial, it was concluded that the cause of the poor prognosis in patients receiving large doses of ESA is an increased incidence of cerebrovascular disorders. However, analyses in the CHOIR and TREAT trials were based on ESA treatment with
Valor da aspartato transaminase no diagnóstico precoce da intoxicação crônica por cobre em ovinos

Atraves da medida da aspartato transaminase (E.C.2.6.1.1.) (AST), foi realizado, por dois anos consecutivos, o controle de 11 Oovinos expostos em feira internacional, procurando-se detectar animais, prestes a desencadear crise hemolitica, devida aintoxicacao cronica por cobre (ICC). No primeiro ano, ocorreram obitos por ICC, e a medida da AST revelou taxas elevadas no sangue dos animais. Metade dosanimais que apresentaram niveis de AST superiores a 600 UI/I morreram em crise hemofilica. Sugere-se que o manejo, oestresse da viagem e da feira, aliados a grande quantidade de racao ingerida, desencadearam a crise. No segundo ano, naoocorreram mortes dos animais e constatou-se a diminuicao dos niveis enzimaticos de AST no sangue. Os dados obtidossugerem que a medida da AST e um bom indicador do desencadeamento da crise hemofilica em ovinos submetidos a dietas rica em cobre.
Oral lipomas in a Brazilian population: a 10-year study and analysis of 450 cases reported in the literature.

OBJECTIVES Lipomas are common benign mesenchymal neoplasms that rarely occur in the oral cavity and correspond to less than 4.4% of all benign oral soft tissue tumors. This study describes the clinical, radiological and histological features of cases of oral lipomas seen over a period of 10 years and compared the findings with those reported in the literature. STUDY DESIGN All cases of oral lipomas seen between 1999 and 2009 were retrieved from the archives of the Stomatology Division of the Federal University of Ceará, Brazil. Age, gender, tumor location, clinical findings, duration, histological subtypes, and treatment outcome were recorded. In addition, the English-language literature was searched for studies published between 1966 and 2009. RESULTS Ten patients (6 women and 4 men) were enrolled in this study. The mean age was 53.4 years (range: 21- 73 years). The specific sites involved were the oral mucosa (n=5), vestibule (n=3), gingiva (n=1), and retromolar region (n=1). The mean size of the tumors was 1.94 cm (range 1.0 to 3.0 cm). Radiographically, only one case appeared as a radiolucent area on occlusal film. Microscopically, 4 cases were classified as simple lipoma, 4 as fibrolipoma, 1 as myxoid lipoma, and 1 as angiolipoma. The duration of the tumors ranged from 2 to 84 months, with a mean duration of 30.4 months. All cases were treated by simple surgical excision and there was no recurrence after a mean post-treatment period of 34.5 months. The findings were compared with 450 cases of oral lipomas reported in the literature. CONCLUSIONS Lipomas continue to be an uncommon neoplasm of the oral cavity. Radiography is a valuable tool due to the possible occurrence of bone involvement. Surgical excision is the treatment of choice and recurrence is not expected.
Identification of Wheel-fashioning Methods: Technological Analysis of 4th–3rdMillenniumBCOriental Ceramics

Abstract In Oriental Asia, during the 4 th –3 rd millennium BC , clay vessels were not wheel-thrown but wheel-shaped. This technique, which combines coiling and wheel-shaping, can be achieved by four methods. These methods are not constrained by technical factors. They may represent cultural behaviour and their identification is potentially an aid towards understanding the historical reasons for the adoption of the wheel. An experimental study was designed to seek and define diagnostic surface features and microfabrics. Comparisons of the results obtained on the experimental materials with a selection of archaeological material have revealed that a variety of wheel-fashioning methods were practised in the past. Contrary to previous conclusions, the choice of these methods evidenced on ancient ceramics did not respond to techno-economic factors such as mass production. The debate concerning the adoption of the wheel in Asia during the 4 th –3 rd millennium BC must therefore be continued.
Physical and mental development of Turkish twins

Abstract Background : Multiple gestations are known to bring some risks in the prenatal and natal period, but whether it is a risk for development in childhood is a matter of debate. The aim of the present study was to evaluate physical and mental development of Turkish twins and then to assess whether being a twin poses risks for their development.
Design of simple noninvasive glucose measuring device

Diabetes is a widely spreading disease according to World Health Organization (WHO). Glucose measurement is the only mean for controlling diabetes. Invasive measurement methods are popular and accurate but they are not comfortable especially for children, elders and pregnant women, some studies refer to the effect of frequent puncturing on skin permeability. The goal of this study is to provide a reliable, simple, painless and portable method for monitoring glucose level without the need of puncturing the skin. Occlusion spectroscopy technique had been used to measure the scattering angle of Near Infrared (NIR) when interacting with glucose molecules within the tissues. A specific range of infrared spectrum (700-1400nm) was used as the incident beam. A linear position detection system was used for scattering angle detection. The system output ranges from 0° to 10°. An inversely proportional relationship between the angle of scattering and the glucose concentration was proved by comparing the resulting scattering angle for nine non-diabetic individuals with glucose concentration estimated value at similar circumstances. The study proved that Occlusion Spectroscopy can provide acceptable results for glucose concentration measurement; where the ratio between glucose concentration and the corresponding angel is (431.83333 ± 79.99444).
Towards quality gates in continuous delivery and deployment

Quality gates, steps required to ensure the reliability of code changes, are supposed to increase the confidence stakeholders have in a release. In today's fast paced environments, we have less time to perform the necessary precautions to minimize the risk of a faulty release. This leads to an inherent trade-off between risk of lower release quality and time to market. We provide a model for this trade-off of release “confidence” and “velocity” that led to the formulation of 4 categories (cautious, balanced, problematic, madness), in which companies can be classified in. We showcase real examples of these categories as case studies based on previous empirical studies. We close by presenting possible transitions between categories that guide future research.
Coping with Creeping Catastrophes: National Political Systems and the Challenge of Slow-Moving Policy Problems

Catastrophes are usually associated with phenomena like tsunamis, earthquakes or asteroid impacts – disasters that happen rapidly with immediately visible impacts. A different logic is involved when problems and challenges evolve incrementally, in slow-motion, and when they only become visible over long periods (Pierson 2004). Jared Diamond recently referred to such changes as “creeping normalcy” (Diamond 2005). Changes are perceived as normality if they happen in unnoticed increments. This concept was used to explain the varying adaptation capacities of human societies to long-term environmental changes.
Expression of an adenovirus encoded reporter gene and its reactivation following UVC and oxidative damage in cultured fish cells

Purpose: Recombinant human adenovirus, AdCA35lacZ, was used to examine expression of a reporter gene and its reactivation following UVC (200–280 nm) and oxidative damage in fish cells. Materials and methods: AdCA35lacZ is a recombinant nonreplicating human adenovirus, which expresses the β-galactosidase (β-gal) reporter gene. UVC light produces DNA damage repaired by nucleotide excision repair (NER). In contrast, methylene blue plus visible light (MB+VL) produces oxidative DNA damage, mainly 8-oxoguanine, that is repaired by base excision repair (BER). We examined expression of the reporter gene and host cell reactivation (HCR) of the UVC-treated and MB+VL-treated reporter gene in fish cells. Results: AdCA35lacZ infection of Chinook salmon cells (CHSE-214), eel cells (PBLE) and four rainbow trout cell lines (RTG-2, RT-Gill, RTS-34st and RTS-pBk), but not zebrafish (ZEB) or carp (EPC) cells resulted in expression of β-gal. HCR of UVC-treated AdCA35lacZ in fish cells varied from that obtained in NER-deficient xeroderma pigmentosum group A fibroblasts to greater than that for NER-proficient normal human fibroblasts. HCR of UVC-treated AdCA35lacZ correlated with β-gal expression levels for untreated AdCA35lacZ. Exposure of cells to fluorescent light (400–700 nm) increased expression of the undamaged reporter gene in normal human fibroblasts and in all fish cells except PBLE and increased HCR of the UVC-damaged reporter gene in fish cells but not in human fibroblasts. HCR of the MB + VL-treated reporter gene was similar to that in human cells for PBLE, CHSE-214, RTG-2 and RTS-pBk, but was reduced in RT-Gill and RTS-34st cells. Conclusions: These results indicate the detection of functional photoreactivation (PR) of UVC-induced DNA damage in fish cells but not in normal human fibroblasts and a link between NER and transcription of the reporter gene in the fish cells in the absence of PR. We show also efficient BER of the reporter gene in several fish cell lines.
Identification of a Protein Subset of the Anthrax Spore Immunome in Humans Immunized with the Anthrax Vaccine Adsorbed Preparation

ABSTRACT We identified spore targets of Anthrax Vaccine Adsorbed (AVA)-induced immunity in humans by screening recombinant clones of a previously generated, limited genomic Bacillus anthracis Sterne (pXO1+, pXO2−) expression library of putative spore surface (spore-associated [SA]) proteins with pooled sera from human adults immunized with AVA (immune sera), the anthrax vaccine currently approved for use by humans in the United States. We identified 69 clones that reacted specifically with pooled immune sera but not with pooled sera obtained from the same individuals prior to immunization. Positive clones expressed proteins previously identified as localized on the anthrax spore surface, proteins highly expressed during spore germination, orthologs of proteins of diverse pathogens under investigation as drug targets, and orthologs of proteins contributing to the virulence of both gram-positive and gram-negative pathogens. Among the reactive clones identified by this immunological screen was one expressing a 15.2-kDa hypothetical protein encoded by a gene with no significant homology to sequences contained in databases. Further studies are required to define the subset of SA proteins identified in this study that contribute to the virulence of this pathogen. We hypothesize that optimal delivery of a subset of SA proteins identified by such studies to the immune system in combination with protective antigen (PA), the principal immunogen in AVA, might facilitate the development of defined, nonreactogenic, more-efficacious PA-based anthrax vaccines. Future studies might also facilitate the identification of SA proteins with potential to serve as targets for drug design, spore inactivation, or spore detection strategies.
Mild Impairment of Cognition Impacts on Activity Participation after Stroke in a Community-Dwelling Australian Cohort

Ongoing disability following stroke can severely impact activity participation and quality of life. The authors investigated the association between cognition and mood and activity participation in 30 survivors of stroke living in the community, using quantitative assessment tools. Non-parametric correlation analyses quantified the presence and strength of association between variables. Differences for those with cognitive impairment or with depressive symptoms were investigated. Survivors of stroke with cognitive impairment of even mild severity had significantly reduced participation in all activity domains. Significant differences in activity participation were not found with mood, although relatively few were identified as being depressed. The findings suggest that mild cognitive impairment after stroke is associated with participation limitations that are important for occupational therapists to consider when planning intervention.
Drug-personality interaction in intensive outpatient treatment.

SOME recent findings indicated that a simple personality scale could be used to predict response to a mild tranquilizer and a placebo. 1,2 The present paper concerns a replication and extension of the drug-personality interaction findings. The personality variable was measured by an abbreviated Bass Social Acquiescence Scale. 3 Scores on the scale indicate degree of agreement with 35 trite generalizations or truisms. A report by Schutz and Foster 4 and unpublished work by this laboratory suggest that the scale does not measure behavioral conformity or social acquiescence as purported. The same researchers found no more than a mild-to-moderate relation to the acquiescent or "yea-saying" response set measured by the Minnesota Multiphasic Personality Inventory (MMPI) and similar tests. 5 Therefore, even though we labeled our experimental groups as High Acquiescers (HA) and Low Acquiescers (LA) on the basis of Bass scores, we prefer at this time
Employment of Air-raid Noises in Psychotherapy

The focus of early bronchogenic tuberculosis must be differentiated from other tuberculous lesions: a primary pulmonary focus, apical Simon foci, "round foci" of dissemination, and the healed residua of a previously unsuspected bronchogenic tuberculosis. It is found as often above as below the clavicle, and appears as a group of small foci or as a non-homogeneous shadow as frequently as in the form of a homogeneous cottonwool shadow (Friihlinfiltrat, or " early infiltration "). Help in deciding whether the lesion is active or not must often be obtained from serial radiographs.
Expression of neuroserpin in the visual cortex of the mouse during the developmental critical period

The neuronal serine protease inhibitor neuroserpin is widely expressed in the developing and adult brain. In the neocortex, neuroserpin is displayed particularly during the period of synaptic specification and refinement, indicating a role as modulator of extracellular proteolytic processes. The synaptic connections of the visual system of the mouse are shaped during early postnatal life by an activity‐dependent process. We have studied the expression of the neuronal serine protease inhibitor neuroserpin in the primary visual cortex of mice from birth until the end of the critical period by means of reverse transcription polymerase chain reaction and in situ hybridization. The localization and the level of expression were constant throughout this period. Monocular deprivation with an eyelid sutured induced a decrease in neuroserpin expression in neurons of area 17 after 1 week of deprivation, the decrease being more pronounced on the side contralateral to the closed eye. The expression of neuroserpin in the visual cortex during the critical period and its decrease in parallel to the refinement of synaptic contacts after visual deprivation suggests a regulative role of neuroserpin on these processes.
Pulsed‐field gel electrophoresis, plasmid profiles and phage types for the human isolates of Salmonella enterica serovar Enteritidis obtained over 13 years in Taiwan

Aims: Plasmid profile, phage typing, and pulsed‐field gel electrophoresis (PFGE) patterns of 124 Salmonella Enteritidis strains isolated in 1998–2002 in Taiwan were analysed and the results were compared with those of the 63 strains obtained in 1991–1997, so that molecular subtypes and epidemic strains for Salmonella Enteritidis over a 13‐year period (1991–2002) could be elucidated.
A Decentralized Multiagent System Approach for Service Restoration Using DG Islanding

This paper proposes a decentralized multiagent system (MAS) approach for service restoration using controlled distributed generator (DG) islanding. Furthermore, it investigates the impacts of vehicle-to-grid (V2G) facility of the electric vehicles (EVs) for service restoration. Service restoration is formulated as a multiobjective optimization problem considering maximization of priority load restored and minimization of switching operations as the multiple objectives and solved using the proposed decentralized MAS approach. Extensive case studies are conducted on 38, 69, and 119 bus distribution systems, and the following advantages of the proposed MAS approach are observed: 1) flexibility-to perform under different DG and EV penetration levels; 2) scalability-to restore service for different size test systems, small as well as large; and 3) robustness-ability to perform efficiently for both single as well as multiple-fault situations. The simulation results also highlight the benefits of V2G feature of EVs for service restoration.
Inflationsdifferenzen im Euroraum: Eine Bestandsaufnahme

In einer Wahrungsunion sind Inflationsdifferenzen zwischen den Mitgliedslandern gleichbedeutend mit Veranderungen des realen Wechselkurses. Dies mag erklaren, warum in jungerer Vergangenheit die Inflationsdifferenzen innerhalb der Europaischen Wahrungsunion verstarkte Aufmerksamkeit in der akademischen Literatur gefunden haben. Der vorliegende Beitrag unternimmt eine Bestandsaufnahme der diesbezuglichen Diskussion. Nach einer kurzen Darstellung der Fakten wird gezeigt, dass die traditionellen Argumente "Preiskonvergenz" und "Balassa-Samuelson-Effekt" die beobachteten Inflationsunterschiede nicht hinreichend erklaren konnen. Anhand eines neu-keynesianischen Makromodells werden strukturelle Unterschiede in den beteiligten Volkswirtschaften als Ursache fur die Inflationsdifferenzen erlautert. Im Einzelnen sind dies landerspezifische Schocks in der Guternachfrage, die asymmetrische Wirkungsweise der Euro/Dollar-Entwicklung und die asymmetrische Wirkungsweise der einheitlichen Geldpolitik.