Miracle-dz/UniFAR-FTUs huggingface dataset:
Large-Scale 3–5 Hz Oscillation Constrains the Expression of Neocortical Fast Ripples in a Mouse Model of Mesial Temporal Lobe Epilepsy

Abstract Large-scale slow oscillations allow the integration of neuronal activity across brain regions during sensory or cognitive processing. However, evidence that this form of coding also holds for pathological networks, such as for distributed networks in epileptic disorders, does not yet exist. Here, we show in a mouse model of unilateral hippocampal epilepsy that epileptic fast ripples generated in the neocortex distant from the primary focus occur during transient trains of interictal epileptic discharges. During these epileptic paroxysms, local phase-locking of neuronal firing and a phase–amplitude coupling of the epileptic discharges over a slow oscillation at 3–5 Hz are detected. Furthermore, the buildup of the slow oscillation begins in the bihippocampal network that includes the focus, which synchronizes and drives the activity across the large-scale epileptic network into the frontal cortex. This study provides the first functional description of the emergence of neocortical fast ripples in hippocampal epilepsy and shows that cross-frequency coupling might be a fundamental mechanism underlying the spreading of epileptic activity.
Emergent high fatality lung disease in systemic juvenile arthritis

Objective To investigate the characteristics and risk factors of a novel parenchymal lung disease (LD), increasingly detected in systemic juvenile idiopathic arthritis (sJIA). Methods In a multicentre retrospective study, 61 cases were investigated using physician-reported clinical information and centralised analyses of radiological, pathological and genetic data. Results LD was associated with distinctive features, including acute erythematous clubbing and a high frequency of anaphylactic reactions to the interleukin (IL)-6 inhibitor, tocilizumab. Serum ferritin elevation and/or significant lymphopaenia preceded LD detection. The most prevalent chest CT pattern was septal thickening, involving the periphery of multiple lobes ± ground-glass opacities. The predominant pathology (23 of 36) was pulmonary alveolar proteinosis and/or endogenous lipoid pneumonia (PAP/ELP), with atypical features including regional involvement and concomitant vascular changes. Apparent severe delayed drug hypersensitivity occurred in some cases. The 5-year survival was 42%. Whole exome sequencing (20 of 61) did not identify a novel monogenic defect or likely causal PAP-related or macrophage activation syndrome (MAS)-related mutations. Trisomy 21 and young sJIA onset increased LD risk. Exposure to IL-1 and IL-6 inhibitors (46 of 61) was associated with multiple LD features. By several indicators, severity of sJIA was comparable in drug-exposed subjects and published sJIA cohorts. MAS at sJIA onset was increased in the drug-exposed, but was not associated with LD features. Conclusions A rare, life-threatening lung disease in sJIA is defined by a constellation of unusual clinical characteristics. The pathology, a PAP/ELP variant, suggests macrophage dysfunction. Inhibitor exposure may promote LD, independent of sJIA severity, in a small subset of treated patients. Treatment/prevention strategies are needed.
EVALUATION OF PELVIC ORGAN PROLAPSE IN INDIAN FEMALES

AIMS: This prospective study was done to evaluate the patients of Pelvic Organ Prolapse (POP) about the duration they are suffering from POP and also the symptoms, the main determinants, degree of prolapse, associated pathologies and the treatment they received. METHODS: This prospective study was done in the patients who reported in Gynecology OPD of our hospital with POP from November 2012 to April 2013. They were asked about the duration they are suffering from prolapse, their chief complaints in detail, the determinants of POP (occupation, BMI, Parity, menopausal status) and were then examined for the degree of prolapse and associated pathologies, complications and the treatment given was recorded. The results are expressed in descriptive statistics by simple percentages with frequency tables. RESULTS: The mean age of women suffering from prolapse was 52.2 years in our study whereas the mean age at which they developed the symptom of something coming out per vaginum was found to be 36.32 years.72. 34% women were postmenopausal. Multiparity is major risk factor for prolapse which is proved by 97.88% women in our study being multiparous. Although obesity was not that major determinant in our study as 59.57% had normal BMI. The most common symptom was something coming out per vaginum (in 97.57%) followed by the disturbances in micturition found in 93.62% women. 80.85% women had third degree prolapse and cystocele was present in 95.74% women. Complications seen were decubitus ulcer, keratinization, elongated and congested cervix and hydronephrosis. Majority (74.4%) underwent vaginal hysterectomy with anterior colporrhaphy and posterior colpo- perineorrhaphy as the treatment of prolapse.
Do Theories of Organizations Progress?

This article analyzes the prospects for cumulative theory development in organization theory. Organization theory generally takes organizations (business corporations, nonprofits, hospitals, universities, etc.) as discrete and meaningful units of analysis. The revolution in information and communication technologies (ICTs) over the past two decades has made comprehensive time-series data on millions of organizations widely available to scholars around the world. Yet, it is not obvious that organization theory has become more precise, more general, or more accurate as a result. The author argues that this is due to three difficulties that additional data cannot fully resolve: (a) researchers lack experimental control, limiting their ability to draw causal inferences, and are largely inattentive to the standards for valid quasi-experimental design; (b) organizations are more appropriately construed as tools rather than as natural objects susceptible to ‘‘laws;’’ and (c) the regularities underlying organizational dynamics change over time such that empirical generalizations that are true during one period may be false in a different period. I conclude by suggesting improvements to research practice that would enable organization theory to progress toward greater insights.
Status and Challenges of Hazardous Waste Managementamong Handlers at Thika Level 5 Hospital, Thika Sub-County, Kiambu County, Kenya

Hazardous wastes are wastes that pose danger both to the public and the environment. Of the total waste generated in health care facilities, approximately 20% is hazardous. These wastes have both immediate and long term health effects including kidney problems, asthma, cancers and other diseases. Hazardous Waste Management (HWM) is a challenge both in the developed world and developing countries where wastes generated are not segregated at the point of generation. Hazardous waste requires special attention throughout all its stages of management. Proper management can significantly reduce the cost of treatment of wastes and diseases due to these wastes. The research aimed at assessing status and challenges of Hazardous Waste Management among handlers in Thika level 5 hospital. The study was cross sectional descriptive and was carried out in Thika level 5 hospital during the month of March, 2014. Data collection instruments included self administered questionnaires, key informant interviews and observation check lists. The sample size was 195 and was selected proportionate to number of hazardous waste handlers in each category. Pretesting of research tools was tested at Ruiru Sub-County hospital. Simple random sampling was used to select study participants. Data collected was managed using SPSS version 20. Results of the study were summarized using percentages, tables and charts. Chi square was used to test for association between variables at p<0.05 significance level. A majority of the respondents had been trained on Hazardous Waste Management and 41.3% of the trained received training more than five years ago. The average amount of waste generated within the hospital was 642kg/day. Almost half (46.0%) of the waste was hazardous waste. There was significant statistical relationship between work experience and use of personal protective equipments (p=0.012), period of training and use of Personal Protective Equipments (p=0.006) and period of training and awareness of color codes (p=0.011). Other factors that were found to have significant relationships with Hazardous Waste Management were awareness of color codes and provider of Personal Protective Equipments. Qualitative analysis revealed that indiscriminate disposal of waste was attributed to inadequate waste bins and lack of clear labeling of bins. It is recommended that the hospital should provide continuous in-service trainings to its healthcare workers in order to equip them with up-to-date information on hazardous waste management. The hospital should ensure provision of adequate waste disposal bins in order to avoid indiscriminate waste disposal.
Fasino, Dario and Tudisco, Francesco (2017) Modularity bounds for clusters located by leading eigenvectors of the normalized modularity

Nodal theorems for generalized modularity matrices ensure that the cluster located by the positive entries of the leading eigenvector of various modularity matrices induces a connected subgraph. In this paper we obtain lower bounds for the modularity of that subgraph showing that, under certain conditions, the nodal domains induced by eigenvectors corresponding to highly positive eigenvalues of the normalized modularity matrix have indeed positive modularity, that is, they can be recognized as modules inside the network. Moreover we establish Cheeger-type inequalities for the cut-modularity of the graph, providing a theoretical support to the common understanding that highly positive eigenvalues of modularity matrices are related with the possibility of subdividing a network into communities.
Market and Style Timing: German Equity and Bond Funds

We apply parametric and non‐parametric estimates to test market and style timing ability of individual German equity and bond mutual funds using a sample of over 500 equity and 350 bond funds, over the period 1990–2009. For equity funds, both approaches indicate no successful market timers in the 1990–1999 or 2000–2009 periods, but in 2000–2009 the non‐parametric approach gives fewer unsuccessful market timers than the parametric approach. There is evidence of successful style timing using the parametric approach, and unsuccessful style timing, particularly in the 2000–2009 period. There is evidence of positive and negative bond timing in the 2000–2009 period.
Fatigue Investigation of the Interface Shear Performance in Asphalt Pavement

This paper shows the interlayer fatigue performance evaluated by the Sapienza shear testing machine. The tests can be performed by placing double layer specimens in several inclinations, in order to reproduce a variety of expected ratios between the normal and the shear stress. The machine manages loads with any kind of waveform and is particularly able to simulate the stress trends expected in field in points located just outside the wheel path. In this experimentation, the machine applies a triangular waveform load computed by a linear elastic multilayer program at the depth of the first pavement interface. A fatigue law is estimated considering the number of repetitions that causes the interface failure. A linear regression in the log-log graph suitably fits the experimental results for the analyzed conditions of temperature and interface type.
Geometric morphometric analysis in female freshwater crabs of Sarawak (Borneo) permits addressing taxonomy-related problems

The taxonomy of freshwater crabs requires a paradigm change in methodological approaches, particularly in investigations that use morphological techniques. The traditional morphometric approach (two-dimensional measurements) tends to be inappropriate for the identification of freshwater crabs due to their variable external morphology and lack of gonopods (conventionally used for the identification of male crabs) in females. In this study, we explore the potential use of the geometric morphometric technique for identification of female freshwater crabs, and identify taxonomic key characteristics of species. The shape of the carapace could be a good characteristic for the identification of female crabs, especially when the geometric morphometric technique is used. It was observed that the shape of the carapace has an advantage over the shape of the pleon and chela because its relatively flat orientation allows more consistent and easier data preparation for geometric morphometric analysis. The geometric morphometric technique is inexpensive, relatively less time consuming to employ, and accurate. This technique is convenient when dissection to examine the gonopods is not possible, which can damage the specimen in the case of endangered or rare species. Since the technique was used herein for only two species, more compelling and extensive evidence is needed before the reliability of the method can be proven.
A Zeldovich reconstruction method for measuring redshift space distortions using cosmic voids

Redshift space distortions (RSD) in the void-galaxy correlation $\xi^s$ provide information on the linear growth rate of structure in low density environments. Accurate modelling of these RSD effects can also allow the use of voids in competitive Alcock-Paczynski measurements. Linear theory models of $\xi^s$ are able to provide extremely good descriptions of simulation data on all scales provided the real space void positions are known. However, by reference to simulation data we demonstrate the failure of the assumptions implicit in current models of $\xi^s$ for voids identified directly in redshift space, as would be simplest using real observational data. To overcome this problem we instead propose using a density-field reconstruction method based on the Zeldovich approximation to recover the real space void positions from redshift space data. We show that this recovers the excellent agreement between theory and data for $\xi^s$. Performing the reconstruction requires an input cosmological model so, to be self-consistent, we have to perform reconstruction for every model to be tested. We apply this method to mock galaxy and void catalogues in the Big MultiDark $N$-body simulation and consistently recover the fiducial growth rate to a precision of $3.4\%$ using the simulation volume of $(2.5\;h^{-1}\mathrm{Gpc})^3$.
Nigerian Oil and Gas Industry Content Development Act's Perceived Performance Impact

Nigerian Oil and Gas Industry Content Development Act’s Perceived Performance Impact by Olakunle T. Ayoola MTech, Curtin University of Technology, 2013 MS, Heriot-Watt University, 2010 BS, University of Ibadan, 2002 Dissertation Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Management
Multielectron Dissociative Ionization of Co2 In Intense Laser Fields

An analytical formula for the electronic stopping power S was derived for swift(v34uo) frozen-charge-state projectiles (atomic number Zl) with two electrons in metastable I s 2 singlet and triplet states, using a first-order perturbation method. Thespatial electron distribution around a projectile was determined by the variational method. In order to demonstrate the magnitude of S. we also calculate the effective stopping-power charge. Compared with the ground state (Is’), Sin the ls2s configuration is found to be enhanced especially at the lowest velocity (u=Z,v,) investigated. In addition, it is found that (i) there is no appreciable difference between ls2s singlet and triplet state, and (ii) S for the ls2s singlet can be scaled in the form Sx Z;‘. ’O.
Introducing nonlinear dynamics to chemical and biochemical engineering graduate students using MATHEMATICA©

In the present paper, we present the solution of four problems drawn from the chemical and biochemical engineering field of study. These problems illustrate various important aspects of nonlinear dynamics such as limit cycles, quasi‐periodic and chaotic behaviors, time series and phase portraits, power spectra, the time‐delay reconstruction diagrams, Hopf bifurcation, bifurcation diagrams, steady state multiplicity… Among a large number of examples, we have selected the following case studies because they illustrate the basic nonlinear dynamics concepts listed previously: (i) The glycolytic oscillator model, first suggested by Sel'kov in 1968 in order to elucidate the mechanism that living cells use to obtain energy from sugar breakdown; (ii) The Oregonator model derived by Field, Körös, and Noyes in the early 1970s, which elucidates the famous oscillatory behavior observed in the Belousov–Zhabotinsky reaction; (iii) The steady state multiplicity in a biochemical reactor for both the Monod and substrate inhibition kinetics; and (iv) The three‐variable autocatalator, first proposed by Peng, Scott, and Showalter in 1990. Finally, we conclude this paper by sharing our experience teaching this subject to graduate students at King Fahd University of Petroleum & Minerals (KFUPM).
Diplomarbeit_Julia Andorfer_proofread

Coworking spaces are resourceful environments enabling new ways of working and social interaction predominantly used by people being self-employed and freelancers. Referring to the Job Demands-Resources model, job resources are directly related to work engagement, whereas personal resources and strategies play a mediating role. However, no study has yet investigated this motivational process for Coworkers. The present study suggested that self-efficacy mediates the relation between job resources and work engagement and self-goal setting acts as mediator between self-efficacy and work engagement. Therefore, an online survey was adapted for Coworkers after a focus group discussion and conducted Europe-wide with 156 Coworkers. Results showed that method control had a positive impact on work engagement. Moreover, self-efficacy was a partial mediator between job control (method and time control) and work engagement. Results lent support that work engagement in coworking spaces is mainly related to method control and mediated by personal resources and strategies. Unexpectedly, there was no relation between social support and work engagement, indicating that social support is not equivalent with social interaction, a characteristic feature of coworking spaces. Thus, further investigations of the social aspect are indicated.
The Effect of Marital Status and Self-Reported Physical Exercise on the Adiposity and Blood Pressure of the Igbos of Nigeria

The effect of marital status and self-reported exercise was investigated in a sample of Igbos in Nigeria. Physical activity level was grouped into: no exercise, irregular exercise and regular exercise. In all the groups, adiposity level and mean BP decreases as the frequencies of physical activity increases and these were significant for weight, BMI, diastolic BP, body circumferences, skinfold thickness except CSF among the married men, while for the never married men significant difference exist only for WC, FAC, SSF among the three groups. For the married women, the three groups of physical activity recorded significant difference in Weight, BMI, WC and HC while the never married women had significant difference only in CSF (F = 4.5, P = 0.01). The result of this study suggests that sex, marital status and exercise have effect on adiposity and blood pressure of the subjects. The married state was conducive for the development of excess adiposity and elevated BP while regular participation in exercise brings a reduction in fat stores and blood pressure. In conclusion, there is a greater tendency for married individuals to be overweight as compared to the never married subjects and regular physical exercise has strong influence in reducing the propensity to increase weight in both men and women.
Comprehensive physical domain care needs of burn patients: a qualitative study

Introduction Burn patients have various physical needs. To provide full care for such patients, we need a broad range of services. The current study aims at showing the physical needs of burn patients. Methods The current qualitative study has been done through content analysis. The data were collected from 20 in-depth, unstructured individual interviews with hospitalized patients with burns on more than 25% of their body, nurses, physiotherapists, and psychologists. The participants were selected by purposive sampling. The data were analyzed with a conventional content analysis approach using the Elo and Kyngas method. Results By analyzing the data, 7 main categories were obtained from 932 primary codes: the necessity to provide optimal physiotherapy, the necessity of the patient’s overall physical assessment, the necessity of monitoring and coordination in care, healthy nutrition for burn patients, the need for pharmacotherapy, the need for pain reliefs, and finally the theme for comprehensive physical care needs in burn patients. Conclusion According to the findings, by applying the extracted categories, it is possible to provide quality care based on the patient’s individual needs. This can help speed up the treatment and shorten the length of hospitalization significantly.
Impact of Leverages on Share Price: Evidence from Cement Sector of Pakistan

This paper examines the impact of different leverage measures on the share price of Cement Sector in Pakistan Stock Exchange. The panel-data approach of fixed effect & random effect is used during the period of 2005 to 2015. To achieve the purpose of research share price is considered as a dependent variable. The results indicate that debt ratio and degree of financial leverage is negatively determining the share price while size has significant positive impact on the share. Debt to equity ratio is insignificant in effecting share price.
Formation of Extrasolar Systems and Moons of Large planets in Clusters

Two models the membrane model and the equivalent model were used for the solution of some of the questions related to formation of the Solar System. Both models show that the planets create clusters in which lies a higher probability of origination of large masses. The rings and belt of asteroids between Mars and Jupiter and the belt of asteroids behind the Neptune track are the beginnings of these clusters. According to the equivalent model, the Solar System went through a different development than other extrasolar systems. Both models show the wave principle, which is the same for other planetary systems and systems of moons of large planets [1]. keywords: Solar system:formation, Planets and satellites, Waves, Asteroids
Chromosome Numbers of Hawaiian Angiosperms: New Records and Comments1

ABSTRACT In this paper chromosome counts for 90 collections representing 67 native Hawaiian angiosperm species and eight hybrids in 22 families are presented and discussed. Included are the first records for 26 species, two sub-specific taxa, eight natural hybrids, and the endemic genus Pteralyxia (Apocynaceae). In four families Hawaiian representatives have been investigated cytologically for the first time. For three species the investigations are the first on Hawaiian material. Seven counts differ from earlier reports in the literature. Implications of the results are discussed in the context of autochthonous chromosomal evolution and of colonization events for the Hawaiian Islands.