Miracle-dz/UniFAR-FTUs huggingface dataset:
Position-Based T-S Fuzzy Power Management for Tram With Energy Storage System

Energy storage systems (ESSs) play a significant role in performance improvement of future electric traction systems. This paper investigates an ESS based on supercapacitors for trams as a reliable technical solution with considerable energy saving potential. Operating the ESS onboard a tram brings the following benefits: reduction of peak power demands, decrease of power consumption, improvement of performance, and efficiency. Whereas the commonly used ESS power management (PM) has been dealing only with PM without vehicle position knowledge, the main emphasis of the presented research is put on position-based Takagi-Sugeno fuzzy (T-S fuzzy) PM for human-driven trams with an ESS. The tram position, located by, e.g., a Global Positioning System module, is used to predict future energy demands and power flows. This information is used in the preparation of the supercapacitor energy level and its power flow control. The optimal ESS power flow with respect to the tram position is a very complex problem. Therefore, soft computing techniques are used in this paper. The main part of the proposed ESS PM is the T-S fuzzy controller. The T-S fuzzy reduces problem dimensionality using expert knowledge represented by the rules. The output membership functions were optimized by differential evolution. The designed ESS PM was verified on real traffic data.
New Interactors of the Truncated EBNA-LP Protein Identified by Mass Spectrometry in P3HR1 Burkitt’s Lymphoma Cells

The Epstein-Barr virus nuclear antigen leader protein (EBNA-LP) acts as a co-activator of EBNA-2, a transcriptional activator essential for Epstein-Barr virus (EBV)-induced B-cell transformation. Burkitt’s lymphoma (BL) cells harboring a mutant EBV strain that lacks both the EBNA-2 gene and 3′ exons of EBNA-LP express Y1Y2-truncated isoforms of EBNA-LP (tEBNA-LP) and better resist apoptosis than if infected with the wild-type virus. In such BL cells, tEBNA-LP interacts with the protein phosphatase 2A (PP2A) catalytic subunit (PP2A C), and this interaction likely plays a role in resistance to apoptosis. Here, 28 cellular and four viral proteins have been identified by mass spectrometry as further possible interactors of tEBNA-LP. Three interactions were confirmed by immunoprecipitation and Western blotting, namely with the A structural subunit of PP2A (PP2A A), the structure-specific recognition protein 1 (SSRP1, a component of the facilitate chromatin transcription (FACT) complex), and a new form of the transcription factor EC (TFEC). Thus, tEBNA-LP appears to be involved not only in cell resistance to apoptosis through its interaction with two PP2A subunits, but also in other processes where its ability to co-activate transcriptional regulators could be important.
Meta‐analysis at middle age: a personal history

The 40‐year history of meta‐analysis is traced from the vantage point of one of its originators. Research syntheses leading to the first examples of meta‐analysis are identified. Early meta‐analyses of the literature on psychotherapy outcomes and school class size are recounted. The influence on the development of meta‐analysis of several statisticians and psychologists is described. Finally, some directions for future development of research synthesis methods are suggested. Copyright © 2015 John Wiley & Sons, Ltd.
Contemporary Mathematics Construction of suitable weak solutions of the Navier-Stokes equations

Weak solutions of the Navier – Stokes system of equations are suitable if they satisfy a localized version of the energy inequality. The interest in this notion is that the partial regularity theorems of Scheffer [10, 11] and Caffarelli, Kohn and Nirenberg [2] apply to suitable weak solutions of the Navier-Stokes equations in three spatial dimensions, limiting the parabolic Hausdorff dimension of their singular set. We show that the weak solutions obtained by the approximation method of Leray [8] are suitable, as are weak solutions obtained by the super-viscosity approximation. However it is not known whether the weak solutions obtained by Hopf’s method of Galerkin approximation [7] are suitable. For the problem on the torus Td we give a new estimate of weak solutions which has some bearing on this question.
'Needle-through-needle' technique for combined spinal-extradural anaesthesia in obstetrics.

that this apparent paradox had to be addressed. We stated that both Libet and Cotterill had proposed that conscious awareness is not necessary for the execution of a simple reaction task. In contrast, we proposed that, in this specific situation (which lies between a conditioned reflex and a voluntary movement), a motor programme might be set up by biasing a set of synapses so that the stimulus automatically triggers the required response. We state that "consciousness is undoubtedly necessary for this programme to be set up and kept in a state of readiness". The later work of Keller and Heckhausen to which Dr Munglani refers is concerned with the initiation of voluntary movements. Whilst this is fascinating in its own right, it is some way from the point of our editorial, which was concerned with conscious awareness. We are sure that Dr Munglani will agree that Libet's work is not familiar to most anaesthetists; nevertheless its wider dissemination will help us to make progress in the difficult problem of understanding and detecting conscious awareness under anaesthesia.
Comparison of Radar Waveforms for a Low-Power Vertical-Incidence Ionosonde

Vertical-incidence (VI) ionosonde is a kind of high-frequency radar. The sounding waveform is an important characteristic for measurement by ionosondes. This letter compares, both theoretically and practically, four different biphase-coded pulse compression radar waveforms which can be employed in the Wuhan Ionosphere Comprehensive Sounding System at VI sounding, including interpulse-coded m sequence, interpulse-coded Wolfman-Goutelard sequence, intrapulse-coded Barker sequence, and intrapulse-coded complementary sequence pairs. The experimental results demonstrate that among the four waveforms, the intraphase-coded complementary-sequence pairs have the best performance.
USP44+ Cancer Stem Cell Subclones Contribute to Breast Cancer Aggressiveness by Promoting Vasculogenic Mimicry

Vasculogenic mimicry (VM), a newly defined pattern of tumor blood supply, describes the functional plasticity of aggressive cancer cells that form vascular networks. In our previous study, breast cancer stem cells (CSC) were shown to potentially participate in VM formation. In this study, breast CSCs presented centrosome amplification (CA) phenotype and ubiquitin-specific protease 44 (USP44) upregulation. USP44 expression contributed to the establishment of bipolar spindles in breast CSCs with supernumerary centrosomes by localizing at pole-associated centrosomes. The bipolar spindle patterns of breast CSCs with CA, including planar-like and apico-basal–like, functioned differently during the VM process of CSCs. Moreover, the ability of transendothelial migration in VM-forming cells was increased. In vivo experiment results showed that CSC xenografts presented linearly patterned programmed cell necrosis, which provided a spatial foundation for VM formation as well as angiogenesis. Breast CSCs further showed increased levels of IL6 and IL8. However, USP44 silencing induced spindle multipolarity, abated VM, reduced transendothelial migration, and consequently decreased IL6 and IL8 levels in breast CSCs. Finally, USP44+ CSC subclones (ALDH1+/USP44+/IL6+/IL8+) were identified in breast cancer specimens through consecutive sections scanning. The subclones were related not only to CA, but also to VM. Statistical analysis suggested that USP44+ CSC subclones could be used as an independent prognostic biomarker of poor clinical outcomes in patients with breast cancer. Collectively, the identification of USP44+ CSC subclones may contribute to the prediction of VM formation and aggressive behavior. This study provides novel insights into the therapy for advanced breast cancer. Mol Cancer Ther; 14(9); 2121–31. ©2015 AACR.
Design and Implementation of Four-Switch Current Sensorless Control for Three-Phase PFC Converter

Four-switch current sensorless control for three-phase four-switch converter with power factor correction (PFC) function is presented in this letter. In comparison with conventional multiloop control methods, the proposed control strategy requires sensing of two line voltages and two capacitor voltages only to achieve PFC function. As there is no sensing current, the proposed sensorless control scheme reduces the cost and complexity of design. The performance of the proposed control is validated by its implementation in digital signal processing (DSP) TMS320F28335, and the result shows that the proposed scheme is able to provide comparable PFC performance without sensing current.
Modeling conflict and error in the medial frontal cortex

Despite intensive study, the role of the dorsal medial frontal cortex (dMFC) in error monitoring and conflict processing remains actively debated. The current experiment manipulated conflict type (stimulus conflict only or stimulus and response selection conflict) and utilized a novel modeling approach to isolate error and conflict variance during a multimodal numeric Stroop task. Specifically, hemodynamic response functions resulting from two statistical models that either included or isolated variance arising from relatively few error trials were directly contrasted. Twenty‐four participants completed the task while undergoing event‐related functional magnetic resonance imaging on a 1.5‐Tesla scanner. Response times monotonically increased based on the presence of pure stimulus or stimulus and response selection conflict. Functional results indicated that dMFC activity was present during trials requiring response selection and inhibition of competing motor responses, but absent during trials involving pure stimulus conflict. A comparison of the different statistical models suggested that relatively few error trials contributed to a disproportionate amount of variance (i.e., activity) throughout the dMFC, but particularly within the rostral anterior cingulate gyrus (rACC). Finally, functional connectivity analyses indicated that an empirically derived seed in the dorsal ACC/pre‐SMA exhibited strong connectivity (i.e., positive correlation) with prefrontal and inferior parietal cortex but was anti‐correlated with the default‐mode network. An empirically derived seed from the rACC exhibited the opposite pattern, suggesting that sub‐regions of the dMFC exhibit different connectivity patterns with other large scale networks implicated in internal mentations such as daydreaming (default‐mode) versus the execution of top‐down attentional control (fronto‐parietal). Hum Brain Mapp, 2012. © 2011 Wiley Periodicals, Inc.
[Complications due to peripheral venous catheterization. Prospective study].

OBJECTIVE Peripheral venous catheter (PVC)-associated complications were prospectively evaluated in a 2 month-study performed in 3 different wards. METHODS For each inserted PVC, the following complications were observed daily by an external investigator: tenderness, erythema, swelling or induration, palpable cord and purulence. PVC that were removed were systematically sent to the Microbiology department and analysed according to the semi-quantitative method described by Brun-Buisson et al. RESULTS A total of 525 PVC (corresponding to 1,036 catheterisation-days) were included. Main clinical complications were erythema (22.1%), tenderness (21.9%), swelling or induration (20.9%), palpable cord (2.7%) and purulence (0.2%). Phlebitis, defined by 2 or more of the following signs: tenderness, erythema, swelling or induration and palpable cord, was observed in 22%. Catheter colonization (> or = 103 CFU/ml) occurred in 13%. Bacteria isolated from colonized catheters were coagulase-negative staphylococci (88.1%), Staphylococcus aureus (7.1%) and Candida sp. (4.8%). Multivariate risk factor analysis showed that age > or = 55 y. (OR = 3.16, p = 0.003), insertion on articulation site (OR = 2.94, p = 0.01) or in jugular vein (OR = 8.18, p = 0.01) and > 72 hour-catheterisation (OR = 4.74, p = 0.0003) were significantly associated with PVC colonization. Risk factors for phlebitis were skin lesions (OR = 1.88, p < 0.016), active infection unrelated to PVC (OR = 2.8, p = 0.001), "poor quality" peripheral vein (OR = 2.46, p < 0.02) and > 72 hour-catherisation (OR = 2.38, p = 0.009). CONCLUSION Complications associated with peripheral venous catheters are frequent but remain benign. They could probably be reduced by a systematic change every 72-96 hours as recommended by different guidelines.
Clinical course of repeated supratherapeutic ingestion of acetaminophen

Background. Repeated supratherapeutic ingestion (RSTI) of acetaminophen (APAP) is recognized as an important cause of APAP-related morbidity and mortality. This study describes the characteristics and clinical course of patients with RSTI, and identifies the risk factors for developing hepatotoxicity and death. Methods. This secondary analysis of a multicenter retrospective chart review studied patients treated with IV and/or oral N-acetylcysteine for acetaminophen poisoning. For this analysis, we included all subjects coded as RSTIs, defined as ingestions of greater than 4 g of APAP per 24 h over a period longer than 8 h. Data collected include demographics, coingestants, comorbidities, presenting laboratory data, and outcomes. The analysis includes descriptive statistics and associations of demographic and clinical factors with patient outcome. Results. Of the 503 patients enrolled, 119 (23.7%) were RSTI. The mean age was 39.6 years (SD ± 15); 63.9% of the patients were females, 60.5% Caucasians, 27.7% alcoholics, 5% malnourished, 10.9% had viral hepatitis, and 3.4% had other liver diseases. Coingestants included ethanol, opioids, and antihistamines (17.6, 48.7, and 19.3%, respectively). Among this group, 44 patients developed hepatotoxicity, two received liver transplants, and four died (37.0, 1.7, and 3.4%, respectively). The risk for hepatotoxicity increased with a history of alcoholism, viral hepatitis, and other liver diseases. A history of alcoholism and an elevated presenting serum creatinine were associated with increased risk for death/transplant. The lowest presenting ALT levels in a subject who developed hepatotoxicity and who died were 252 and 426 IU/l, respectively. Conclusion. RSTI-induced hepatotoxicity and poor outcomes can be predicted at the patient's presentation. All patients with RSTI who developed hepatotoxicity presented with an abnormal ALT. A history of alcoholism and an elevated creatinine at presentation are markers of increased risk for hepatotoxicity and death.
A slow suicide: the seemingly infinite cycle of alcohol and trauma in a middle-aged woman.

M s. A is a never-married, unemployed woman of mixed European descent in her early 40s living with her boyfriend in a small town outside of Boston. At the time of presentation, she had a history of multiple past psychiatric hospitalizations and suicide attempts, and of chronic noncompliance with any outpatient psychiatric treatment for her depression and posttraumatic stress disorder (PTSD). When Ms. A presented to the emergency department for an overdose suicide attempt and altered mental status, it was her thirteenth visit to the emergency department in 18 days. She presented somewhat differently than with her usual alcohol intoxication and pain. On this admission she had taken an intentional overdose of 15 tablets of clonidine in a suicide attempt. Although her vital signs were stable and she became alert, she was admitted to the ICU for treatment of dangerously low potassium levels. She was evaluated in the ICU by psychiatry. She was found to be too irritable to tolerate more than a minimal interview. When the psychiatrist repeated a question, Ms. A would immediately start to scream in rage. She later described this reaction as her “Italian temper. ” According to the ICU nurses who knew her well, Ms. A looked worse than ever. She had lost weight, teeth, and hair since her last admission. She had bruises, cuts, and scars all over her body. Many of the staff had a palpable feeling of hostility toward Ms. A. They thought that Ms. A had not attempted suicide but instead was seeking drugs. The nurses thought that the overdose of clonidine was an attempt to get high and that Ms. A should be discharged as soon as possible. Ms. Awas stabilized medically and transferred to the inpatient psychiatric unit.
Development and psychometric testing of the Breastfeeding Self-Efficacy Scale.

Many new mothers discontinue breastfeeding prematurely. Researchers have shown that maternal confidence is an important factor in the continuation of breastfeeding. The purpose of this methodological study was to develop and conduct preliminary psychometric assessment of an instrument to measure confidence in new breastfeeding mothers. Using self-efficacy theory as a conceptual framework, the Breastfeeding Self-Efficacy Scale (BSES) was developed and content validity was judged by a panel of experts and through interviews with experienced breastfeeding mothers. Following a pilot test, the revised BSES was assessed with 130 in-hospital breastfeeding mothers for reliability and validity, including internal consistency, principal components factor analysis, comparison of contrasted groups, and correlations with measures of similar constructs. Support for predictive validity was demonstrated with positive correlations between BSES scores and infant feeding patterns at 6 weeks postpartum. Following further testing, this instrument may be used to identify new mothers with low breastfeeding confidence who are at high risk to prematurely discontinue breastfeeding.
Parastomal Hernia Repair and Reinforcement: The Role of Biologic and Synthetic Materials

Abstract Parastomal hernia is a prevalent problem and treatment can pose difficulties due to significant rates of recurrence and morbidities of the repair. The current standard of care is to perform parastomal hernia repair with mesh whenever possible. There exist multiple options for mesh reinforcement (biologic and synthetic) as well as surgical techniques, to include type of repair (keyhole and Sugarbaker) and position of mesh placement (onlay, sublay, or intraperitoneal). The sublay and intraperitoneal positions have been shown to be superior with a lower incidence of recurrence. This procedure may be performed open or laparoscopically, both having similar recurrence and morbidity results. Prophylactic mesh placement at the time of stoma formation has been shown to significantly decrease the rates of parastomal hernia formation.
A Non-Volatile 2Mbit CBRAM Memory Core Featuring Advanced Read and Program Control

A 2Mbit CBRAM (conductive bridging random access memory) core has been developed utilizing a 90nm, VDD = 1.5V process technology. The presented design uses an 8F2 (0.0648mum2) 1T1CBJ (1-transistor/1-conductive bridging junction) cell and introduces a fast feedback regulated CBJ read voltage and a novel program charge control using dummy cell bleeder devices. Random read/write cycle times les50ns are demonstrated
A first-principle investigation of antigorite up to 30 GPa: Structural behavior under compression

Abstract The structure of antigorite (m = 17) has been studied by density functional theory from 0 to 30 GPa. The fourth-order Birch-Murnaghan equation of state fit of the thermally corrected LDA results yields an equilibrium volume (V0 = 2853.13 Å3), bulk modulus (K0 = 64.6 GPa), and its pressure derivative (K0′ = 6.94) in good agreement with experimental results. Two changes in compression mechanism occur at 6.1 and 20.5 GPa, individuating three pressure ranges: (1) in the low-pressure range, the antigorite wave flattens and the interlayer thickness decreases rapidly; (2) in the intermediate-pressure range, in-plane rotations of tetrahedra (ditrigonalization) and then wave-bending become the dominant compression mechanisms; (3) in the extreme-pressure range, the mechanism of wave-bending becomes prevalent. The first change reveals the origin of softening found experimentally near 6 GPa: the change in compression mechanism occurs after the minimal mismatch between T- and O-sheets is achieved and is accompanied by an apparent symmetry breaking: accidental degeneracies of structural parameters between short and long halfwaves are lifted, including T-sheet thicknesses and Si-O bond lengths. In the extreme-pressure range, Si-O-Si angles decrease below 122°, which may be the origin of amorphization found experimentally at similar pressure.
Expression of MUC4 Mucin Is Observed Mainly in the Intestinal Type of Intraductal Papillary Mucinous Neoplasm of the Pancreas

Objectives This study aimed to examine expression profile of MUC4 in intraductal papillary mucinous neoplasm of the pancreas (IPMN). Methods We performed immunohistochemistry (IHC) of MUC4 in 142 IPMNs, with evaluation of the specificity of 2 anti-MUC4 monoclonal antibodies, 8G7 and 1G8, in cancer cell lines. Results Monoclonal antibody 8G7 showed a clear immunoreactivity, whereas MAb 1G8 did not show any immunoreactivity, in the Western blotting and IHC for human pancreatic carcinoma cell lines expressing MUC4 messenger RNA. However, IHC signals detected by both monoclonal antibodies were observed in the tissue specimens. The expression rates of MUC4/8G7 detected by MAb 8G7 and MUC4/1G8 detected by MAb 1G8 in the intestinal-type IPMNs were significantly higher than those in the gastric-type IPMNs. In the intestinal-type IPMNs, MUC4/8G7 was expressed mainly in the cytoplasm of the neoplastic cells, whereas MUC4/1G8 was expressed mainly at the cell apexes. Even in the gastric-type IPMNs with rare MUC4 expression in the low-grade dysplasia, both MUC4 expression rates increased when dysplasia advanced. Conclusions A significantly higher expression of MUC4 in intestinal-type IPMNs than in gastric-type IPMNs will be one of the biomarkers to discriminate between the intestinal-type IPMNs with high malignancy potential from gastric-type IPMNs with low malignancy potential.
[Severe maternal anemia and pregnancy outcome].

OBJECTIVES The aim of this study was to determine the effects of severe antenatal maternal anemia on pregnancy outcome. MATERIAL and methods. A retrospective study comparing 2 groups of pregnant women: 111 (pregnant women) with anemia (Hb < 8 g/dl), 111 non- anemic pregnant women (Hb >10 g/dl). Clinical and biological characteristics for both groups were compared. Data on the newborn babies were collected. RESULTS In the anemic group: iron deficiency was the most common cause of anemia (92.7%). There was no significant difference between the 2 groups with respect to age or parity. Maternal anemia was found to be significantly associated with more frequent preterm birth (29.2% vs 9.2%) and increased low birth weight (2933 g vs 3159 g). DISCUSSION The literature is not conclusive on the influence of anemia in pregnant women. More frequent preterm birth and low birth weight have been reported in the majority of studies considering mild to moderate maternal anemia (in contrast to our study where the mothers had severe anemia). Many studies indicated that routine iron supplementation during pregnancy may have beneficial effects on pregnancy outcome. Severe anemia in pregnancy may have adverse effects for the newborn and should be treated or prevented early in pregnancy.