Miracle-dz/UniFAR-FTUs huggingface dataset:
Notes from the Field: Evidence of Zika Virus Infection in Brain and Placental Tissues from Two Congenitally Infected Newborns and Two Fetal Losses--Brazil, 2015.

Zika virus is a mosquito-borne flavivirus that is related to dengue virus and transmitted primarily by Aedes aegypti mosquitoes, with humans acting as the principal amplifying host during outbreaks. Zika virus was first reported in Brazil in May 2015 (1). By February 9, 2016, local transmission of infection had been reported in 26 countries or territories in the Americas. * Infection is usually asymptomatic, and, when symptoms are present, typically results in mild and self-limited illness with symptoms including fever, rash, arthralgia, and conjunctivitis. However, a surge in the number of children born with microcephaly was noted in regions of Brazil with a high prevalence of suspected Zika virus disease cases. More than 4,700 suspected cases of microcephaly were reported from mid-2015 through January 2016, although additional investigations might eventually result in a revised lower number (2). In response, the Brazil Ministry of Health established a task force to further investigate possible connections between the virus and brain anomalies in infants (3).
Locomotion in the abalone Haliotis kamtschatkana: pedal morphology and cost of transport

Morphological analyses of pedal sole area and pedal waves were conducted for a range of speeds and body sizes in the abalone Haliotis kamtschatkana. The pedal sole of resting abalone increased in size disproportionately with animal volume (slope of log10-transformed data, b=0.83; expected slope for isometry, b0=0.67) and length (b=2.51; b0=2.0). Pedal wave frequency increased linearly with speed, confirming that abalone increase speed by increasing the velocity of pedal waves. Total area of the pedal sole decreased by 2.1 % for each shell length per minute increase in speed. Likewise, the area of the foot incorporated into pedal waves increased by 1.8 % for each shell length per minute increase in speed. Together, these changes translated into a 50 % decrease in the pedal sole area in contact with the substratum at a maximum escape speed of 15 shell lengths min-1, relative to the pedal sole at rest. The amount of mucus secreted by resting animals during adhesion to the substratum increased isometrically with foot area (slope of log10-transformed data, b=1.08). The amount of mucus secreted during locomotion did not vary with speed, but was less than the amount needed for adhesion. We suggest that these morphological and physiological changes reduce the energy expenditure during locomotion. Cost of transport was investigated for a range of speeds and abalone sizes. The rate of oxygen consumption O2 (in µl O2 g-1 h-1) increased linearly with increasing absolute speed v (in cm min-1): O2=40.1+0.58v-0.15m (r2=0.35, P=0.04), where m is body mass (in g). Minimum cost of transport, calculated from the slope of absolute speed on O2, was 20.3 J kg-1 m-1. Total cost of transport (COTT) and net cost of transport (COTN) were high at low speeds and decreased as speed increased, to minima of 86.0 J kg-1 m-1 and 29.7 J kg-1 m-1, respectively, at speeds measured in the respirometer. Log10-transformation of both cost of transport and speed data yielded linear relationships with the following regression equations: log10COTT=3.35-0.90log10v-0.21log10m (r2=0.89; P<0.006) and log10COTN=2.29-0.69log10v-0.09log10m (r2=0.48; P<0.006), respectively.
The Impact of Age and Intrauterine Contraception on the Clinical Course of Pelvic Inflammatory Disease

Background: The aim of the study was to investigate the clinical course of pelvic inflammatory disease (PID) and factors that could predict failed conservative treatment of PID. Additionally, the study aimed to examine the role of age and intrauterine device (IUD) use on the severity of PID. Method: Fifty-one women admitted to hospital with the diagnosis of acute PID were recruited. Of those, 17 patients were subsequently operated because of failed conservative treatment. All women underwent careful examination and completed a questionnaire at admission. Their clinical course was followed and the clinician responsible for the patient completed forms at admission and at discharge. Two groups were established retrospectively, those who were treated conservatively and those who underwent surgery. The outcome results were analyzed with regard to IUD use, duration of IUD use (≧5 or <5 years), and with regard to age below or above 35 years. All data were analyzed using the statistical package SAS. A p value <0.05 was considered significant. Results: Women who subsequently underwent surgical treatment were significantly older and significantly more frequently, current IUD users. There was no significant difference with regard to other socio-demographic characteristics. Women who subsequently underwent surgery had significantly more frequent complaints of severe abdominal pain, elevated body temperature, symptoms of peritoneal irritation, and appearance of adnexal mass. No differences were found between groups with regard to anaerobic microbiological findings, nor with regard to the finding of Actinomyces. IUD use and age ≧35 were found to be highly significant risk factors for surgery in patients with PID. Conclusion: Age over 35 years and IUD use, independently of each other, were factors strongly associated with an increased risk of surgery for PID as a result of failed conservative treatment.
Depression among Chinese stroke survivors six months after discharge from a rehabilitation hospital.

AIM AND OBJECTIVE The primary aim was to examine the prevalence of poststroke depression in Chinese stroke survivors six months after discharge from a rehabilitation hospital. A second aim was to determine whether six-month poststroke depression was associated with psychological, social and physical outcomes and demographic variables. BACKGROUND There has been increasing recognition of the influence of depression on poststroke recovery. While some previous studies report associations between depression and social, psychological, physical and clinical outcomes, few studies had sufficient sample sizes for regression analysis thereby limiting the clinical applicability of their findings. DESIGN A cross-sectional design was used. METHOD Data were collected from 124 male and 86 female stroke survivors (mean age 71.7, SD 10.2 years). The Geriatric Depression Scale was used to measure depression, the State Self-esteem Scale to measure state self-esteem, the London Handicap Scale to measure participation restriction, the Social Support Questionnaire to measure satisfaction with social support and the Modified Barthel Index to measure functional ability. RESULTS Forty-two survivors (20.5%) reported mild and 33 (16.1%) reported severe depression. The presence of depression was associated with low levels of state self-esteem, social support satisfaction and functional ability. Logistic regression analysis revealed that these variables were statistically significant in predicting the probability of having depression (p < 0.05). CONCLUSIONS Analyses in the present study revealed distinct patterns of correlates of depression, and the results were in agreement with prior studies that depression has a consistent positive association with physical disability, living arrangements and social support and no significant association with the different types of brain lesion. RELEVANCE TO CLINICAL PRACTICE There is a need, routinely, to assess stroke survivors for depression and, where necessary, to intervene with the aim of enhancing psychological and social well-being.
Assessing roadblocks to justice: A model of fair behavior in organizations

Organizational justice research traditionally focuses on individuals’ reactions to how they are treated by others. However, little attention has been given to why individuals choose to behave fairly or unfairly in the first place. Our chapter draws on the literature in ethical decision making (Rest, 1986) to identify five distinct factors that influence an individual's decision to treat others fairly. Using this model as a foundation, and drawing on extant research in justice, we explore five different types of roadblocks to fair behavior. We explore the implications of these roadblocks for organizations concerned with creating and maintaining a fair workplace. Finally, we discuss future research suggested by the five factors and some dilemmas, issues, and caveats relevant to the proposed model.
The Statistical Conditions for a Change in Business Concentration

ONE of the ways of tracing changes in business concentration is to compare the rates of growth of firms of different sizes. If firms that are large at a certain date subsequently grow on the average more rapidly than small firms, business concentration will obviously have increased. It is not however always realized that the obverse proposition does not hold; that is, if the large firms have grown less rapidly than the small firms then -however paradoxical it may seem -concentration does not necessarily decrease. A related paradox -that associated with what is known as "jobbing backward" arises if we look at the average rate of growth achieved in the past by firms that are large today, and compare it with that for smaller firms. This differs from the previous example, since we are now looking backward in time instead of forward; as will be seen below, the two points of view are symmetrically related to one another. The matter is more complicated in its logic than appears at first sight, and it is perhaps not surprising that many careful empirical investigations are to be found in the literature which are vitiated by a logical fault in the inferences drawn from them. The errors are generally pointed out subsequently, only to be repeated by the next generation. The present note attempts to give a simplified but systematic exposition of the necessary conditions for changes in concentration; the basic algebra has already been set out from a different point of view in an earlier paper,' but the approach adopted here may be easier to follow. The statistician will recognize all that follows as being no more than the simple theory of regression in the sense of Galton (not in the modern sense, where "regression" is often taken as equivalent to the procedure of fitting a line by least-squares). Our understanding of the problem owes much to the review by Hotelling in the Journal of the American Statistical Association, xvIII (933), 463-65 of Secrist's The Triumph of Mediocrity in Business (Chicago, I933), and the subsequent discussion, ibid., XIX (I934), I96-2 00.2 Similar arguments are to be found in other contexts in the writings of Professor Milton Friedman.
Robust Blood-Glucose Control using Mathematica

A robust control design on frequency domain using Mathematica is presented for regularization of glucose level in type I diabetes persons under intensive care. The method originally proposed under Mathematica by Helton and Merino, now with an improved disturbance rejection constraint inequality - is employed, using a three-state minimal patient model. The robustness of the resulted high-order linear controller is demonstrated by nonlinear closed loop simulation in state-space, in case of standard meal disturbances and is compared with Hinfin design implemented with the mu-toolbox of Matlab. The controller designed with model parameters represented the most favorable plant dynamics from the point of view of control purposes, can operate properly even in case of parameter values of the worst-case scenario
Improving survival after in-hospital cardiac arrest: the Australian experience.

BACKGROUND Survival rates after in-hospital cardiac arrest have not improved markedly despite improvements in technology and resuscitation training. OBJECTIVES To investigate clinical variables that influence return of spontaneous circulation and survival to discharge after in-hospital cardiac arrest. METHODS An Utstein-style resuscitation template was implemented in a 750-bed hospital. Data on 158 events were collected from January 2004 through November 2004. Significant variables were analyzed by using a multiple logistic regression model. RESULTS Of the 158 events, 128 were confirmed cardiac arrests. Return of spontaneous circulation occurred in 69 cases (54%), and the patient survived to discharge in 41 (32%). An initial shockable rhythm was present in 42 cases (33%), with a return of spontaneous circulation in 32 (76%) and survival to discharge in 24 (57%). An initial nonshockable rhythm was present in the remaining 86 cases (67%), with a return of spontaneous circulation in 37 (43%) and survival to discharge in 17 (20%). Witnessed or monitored arrests (P=.006), time to arrival of the cardiac arrest team (P=.002), afternoon shift (P=.02), and initial shockable rhythm (P=.005) were independently associated with return of spontaneous circulation. Location of patient in a critical care area (P=.002), initial shockable rhythm (P<.001), and length of resuscitation (P=.02) were independently associated with survival to hospital discharge. CONCLUSIONS The high rate of survival to discharge after cardiac arrest is attributed to extensive education and the incorporation of semiautomatic external defibrillators into basic life support management.
Antimicrobial Resistance of 914 Beta-Hemolytic Streptococci Isolated from Pharyngeal Swabs in Spain: Results of a 1-Year (1996–1997) Multicenter Surveillance Study

ABSTRACT A nationwide susceptibility surveillance study of beta-hemolytic streptococcal isolates from pharyngeal swabs obtained in 11 Spanish hospitals between May 1996 and April 1997 against 12 antibiotics was carried out. Of the isolates 86% (786 of 914 isolates) were group A and 8.4% (77 of 914 isolates) were group C. No resistance was found to β-lactam antibiotics, but significant differences (P< 0.001) with respect to lack of susceptibility to macrolides were found between groups (27% for group A and 12% for group C) and between seasons (13.2% in summer and 31.7% in winter). Most of these isolates displayed the M phenotype (low-level resistance to erythromycin and susceptibility to clindamycin).
Effect of cardiorespiratory training on aerobic fitness and carryover to activity in children with cerebral palsy: a systematic review

The question under consideration was does cardiorespiratory training improve aerobic fitness in children with cerebral palsy and is there any carryover into activity? The study design consisted of a systematic review of randomized trials using the Cochrane Collaboration guidelines. Participants were children of school age with cerebral palsy. Intervention included cardiorespiratory training consisting of activities conducted for an extended period, which were progressed in terms of duration and/or intensity over time. Combination programs were included if cardiorespiratory training comprised at least half of the program. Outcomes had to include a measure of aerobic fitness, for example, peak oxygen uptake. In addition, measures of activity that reflect aerobic fitness, for example, 6-min Walk Test were also desirable. Three studies were identified which randomized participants to cardiorespiratory training or no intervention in addition to usual physiotherapy. A meta-analysis was not performed because of lack of data. Therefore, the between-group differences are reported in terms of percentage benefit. Short-term cardiorespiratory training (i.e. 2–4 months) increased aerobic fitness by 18–22% and long-term training (i.e. 8–9 months) by 26–41% compared with no additional intervention. Short-term training (i.e. 2–4 months) increased activity by 0–13%, and long-term training (i.e. 8–9 months) by 2–9%. The conclusion is that there is limited evidence about the effect of cardiorespiratory training in children with cerebral palsy. The available evidence suggests that training may improve aerobic fitness, but that there is little carryover into activity.
Hemodynamic and respiratory responses in halothane-anesthetized horses exposed to positive end-expiratory pressure alone and with dobutamine.

The influence of positive end-expiratory pressure (PEEP) on the alveolar-arterial O2 tension difference [P(A-a)O2], physiologic right-to-left shunt fraction, physiologic dead space-to-tidal volume ratio, and hemodynamic variables was studied in halothane-anesthetized horses maintained in dorsal recumbency during controlled ventilation. Dobutamine was used to minimize the adverse cardiovascular consequences of PEEP. Six adult horses were anesthetized, using xylazine (2.2 mg/kg of body weight, IM), guaifenesin (50 mg/kg, IV), thiamylal Na (4.4 mg/kg, IV), and halothane (1.5 to 2% inspired) in 100% O2. Mechanical ventilation was controlled to maintain arterial eucapnia for at least 45 minutes during base-line measurements. Hemodynamic and respiratory variables were determined every 15 minutes during equilibration. Each horse was subjected to 4 randomized treatments: 5 cm of H2O PEEP, 10 cm of H2O PEEP, 5 cm of H2O PEEP plus dobutamine (1 microgram/kg/min), and 10 cm of H2O PEEP plus dobutamine (1 microgram/kg/min). Each treatment lasted 15 minutes and immediately followed its predecessor. Although the magnitude of PEEP was randomized with and without dobutamine, PEEP without dobutamine always preceded PEEP with dobutamine. Differences in hemodynamic or respiratory variables among base-line measurements, 5 cm of H2O PEEP, or 10 cm of H2O PEEP were not significant (P greater than 0.05). (ABSTRACT TRUNCATED AT 250 WORDS)
Material hardship and children's social‐emotional development: Testing mitigating effects of Child Development Accounts in a randomized experiment

BACKGROUND Research has established a negative association between household material hardship and children's mental health. This study examines whether Child Development Accounts (CDAs), an economic intervention that encourages families to accumulate assets for children's long-term development, mitigate the association between material hardship and children's social-emotional development. METHODS Researchers conducted a randomized experiment of CDAs in Oklahoma, USA, with a probability sample (N = 7328) of all infants born in two 3-month periods in 2007. After agreeing to participate in the experiment, caregivers of 2704 infants completed a baseline survey and were assigned randomly to the treatment (n = 1358) or control group (n = 1346). The intervention exposed the treatment group to a CDA, which consisted of an Oklahoma 529 College Savings Plan account, financial incentives and financial information. RESULTS Material hardship has a negative association with the social-emotional development of children around the age of 4 years. Estimates from regression analysis indicate that CDAs mitigate about 50% of the negative association between material hardship and children's social-emotional development. CONCLUSIONS Although they do not provide direct support for consumption in households experiencing material hardship, CDAs may improve child development by influencing parenting practices and parents' expectations for their children. We discuss the implications of using asset-building programmes to improve child development.
On the subdivision of static and dynamic fusimotor actions on the primary ending of the cat muscle spindle.

1. Using large ramp and triangular stretches a survey has been made of the effect of stimulating single gamma fusimotor fibres on primary endings of muscle spindles in the peroneus brevis to see whether 'intermediate' types of fusimotor action could be recognized, falling between the well known static and dynamic types. 2. Responses were classified into six groups, as detailed on pp. 844‐846, ranging from apparently 'pure' dynamic action (category I) to apparently 'pure' static action (category IV). Models for a putative mixed action were produced by combining the stimulation of a static and of a dynamic fibre to the same spindle. The clearest sign of static action was firing on the releasing phase of the stretch. The essential sign of dynamic action, which survived combination with the more dominant static action, was the low adaptive decay of firing with a time constant of about 0‐5 sec that occurs on the plateau of the ramp stretch. 3. Out of 153 responses, each elicited from a primary ending on stimulation of a single fusimotor fibre, 67% were apparently 'pure' examples of dynamic and static action. The remaining 33% of responses were to some degree suggestive of an admixture, in various proportions, of static and dynamic actions. For only 18% of them was there firm indication of such admixture. 4. When a given fibre was tested on more than one ending then, with one exception out of thirty‐six instances, its action always proved to be either predominantly static or predominantly dynamic. There was no special tendency for an axon with a mixed action on one spindle to have a similarly mixed action on other endings so that individual fusimotor fibres were best classified as static or dynamic without intermediate grades. 5. Simultaneous stimulation of two fusimotor fibres eliciting apparently 'pure static and dynamic actions, could mimic all the intermediate types of action. 6. The results are discussed in relation to recent studies, especially those based on glycogen depletion. It was concluded that dynamic action arises from activation of the bag1 intrafusal muscle fibre, and that static action arises from the bag2 and chain fibres, whether acting individually or collaboratively. The intermediate actions are suggested to arise from an overlap of motor innervation to contrasting types of intrafusal muscle fibre. 7. On the basis of effects on the regularity of the afferent discharge the findings support the view that a given static action axon can innervate bag2 and chain fibres in various proportions in different spindles, so that they do not provide separable effector pathways. 8. Responses to large amplitude sinusoidal stretching were also studied in relation to our classification.
Topological Signals of Singularities in Ricci Flow

We implement methods from computational homology to obtain a topological signal of singularity formation in a selection of geometries evolved numerically by Ricci flow. Our approach, based on persistent homology, produces precise, quantitative measures describing the behavior of an entire collection of data across a discrete sample of times. We analyze the topological signals of geometric criticality obtained numerically from the application of persistent homology to models manifesting singularities under Ricci flow. The results we obtain for these numerical models suggest that the topological signals distinguish global singularity formation (collapse to a round point) from local singularity formation (neckpinch). Finally, we discuss the interpretation and implication of these results and future applications.
Heritability of personality disorders in childhood: a preliminary investigation.

The heritability of personality disorder features was investigated in 112 child (ages 4-15 years) twin pairs (70 monozygotic and 42 dizygotic pairs). Parents assessed personality disorder features using the Coolidge Personality and Neuropsychological Inventory for Children (CPNI; Coolidge, 1998) that measures 12 personality disorders according to the criteria in the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) (American Psychiatric Association, 1994). Structural equation model-fitting methods indicated that the median heritability coefficient for the 12 scales was . 75 (ranging from .81 for the Dependent and Schizotypal Personality Disorder scales to .50 for the Paranoid and Passive-Aggressive Personality Disorder scales). These results suggest that childhood personality disorders have a substantial genetic component and that they are similar to heritability estimates of personality disorder traits in adults and counter hypotheses that only temperaments and higher-order personality disorder traits have significant genetic components (Paris, 1997).