Miracle-dz/UniFAR-FTUs huggingface dataset:
Spatiotemporal and Kinetic Determinants of Sprint Acceleration Performance in Soccer Players

We aimed to elucidate spatiotemporal and kinetic determinants of sprint acceleration performance in soccer players. Thirty-seven male soccer players performed 60-m sprints. The spatiotemporal variables and ground reaction impulses were calculated over a 50-m distance. When controlling the influence of stature and body mass, change in running speed was correlated with the step length at the 1st–4th step section (r = 0.695), step frequency from the 9th to 20th step sections (r = 0.428 to 0.484), braking impulse during the 17th–20th step section (r = 0.328), propulsive impulse from the 1st to 8th step sections (r = 0.738 and 0.379), net anteroposterior impulse for all step sections (r = 0.384 to 0.678), and vertical impulse from the 9th–12th step section and thereafter (r = −0.355 to −0.428). These results confirmed that an effective acceleration is probably accomplished by a greater step length originated in greater propulsive impulse during the initial acceleration phase (to the 8th step), a higher step frequency through smaller vertical impulse and smaller braking impulse during the middle and later acceleration phases (from the 9th step), as well as greater net anteroposterior impulse during the entire acceleration phase.
The Interdisciplinary Health Care Team: A Handbook

Give us 5 minutes and we will show you the best book to read today. This is it, the interdisciplinary health care team a handbook that will be your best choice for better reading book. Your five times will not spend wasted by reading this website. You can take the book as a source to make better concept. Referring the books that can be situated with your needs is sometime difficult. But here, this is so easy. You can find the best thing of book that you can read.
Multiple psychological factors predict abdominal pain severity in children with irritable bowel syndrome

Anxiety and depression are implicated as contributors to abdominal pain in pediatric irritable bowel syndrome (IBS) but is unclear if this pain is associated with other psychological factors. The study objective was to test if the impact of anxiety or depression on IBS symptom severity is mediated by somatization and/or pain catastrophizing.
Model for Dynamic and Hierarchical Data Repository in Relational Database

The aim of this research is to build an open schema model for digital sources repository in the relational database. It required us to develop a few advanced techniques. One of them was to keep and maintain a hierarchical data structure pushed into the repository. The second was to create constraints on any hierarchical level that allow enforcing data integrity and consistency. The created solution is mainly based on a JSON as a native column type, which was designed for holding open schema documents. In this paper, we present the model for any repository that uses hierarchical dynamic data. Additionally, we include a structure for normalizing input and description for data to keep all the model assumptions. We compared our solution with well-known open schema model -- Entity-Attribute-Value -- in the scope of saving data and querying about relationship and content from structure. Results have shown that we achieved improvement in both performance and disk space usage, although we extended our model with a few new features that the previous model does not include. The techniques developed in this research can be applied in every domain where hierarchical dynamic data is required, as demonstrated by the digital book repository that we have presented.
From Synapse to Function: A Perspective on the Role of Neuroproteomics in Elucidating Mechanisms of Drug Addiction

Drug addiction is a complex disorder driven by dysregulation in molecular signaling across several different brain regions. Limited therapeutic options currently exist for treating drug addiction and related psychiatric disorders in clinical populations, largely due to our incomplete understanding of the molecular pathways that influence addiction pathology. Recent work provides strong evidence that addiction-related behaviors emerge from the convergence of many subtle changes in molecular signaling networks that include neuropeptides (neuropeptidome), protein-protein interactions (interactome) and post-translational modifications such as protein phosphorylation (phosphoproteome). Advancements in mass spectrometry methodology are well positioned to identify these novel molecular underpinnings of addiction and further translate these findings into druggable targets for therapeutic development. In this review, we provide a general perspective of the utility of novel mass spectrometry-based approaches for addressing critical questions in addiction neuroscience, highlighting recent innovative studies that exemplify how functional assessments of the neuroproteome can provide insight into the mechanisms of drug addiction.
Methods for Evaluating the Combined Effects of Chemical and Nonchemical Exposures for Cumulative Environmental Health Risk Assessment

Cumulative risk assessment (CRA) has been proposed as a means of evaluating possible additive and synergistic effects of multiple chemical, physical and social stressors on human health, with the goal of informing policy and decision-making, and protecting public health. Routine application of CRA to environmental regulatory and policy decision making, however, has been limited due to a perceived lack of appropriate quantitative approaches for assessing combined effects of chemical and nonchemical exposures. Seven research projects, which represented a variety of disciplines, including population health science, laboratory science, social sciences, geography, statistics and mathematics, were funded by the US Environmental Protection Agency (EPA) to help address this knowledge gap. We synthesize key insights from these unique studies to determine the implications for CRA practice and priorities for further research. Our analyses of these seven projects demonstrate that the necessary analytical methods to support CRA are available but are ultimately context-dependent. These projects collectively provided advancements for CRA in the areas of community engagement, characterization of exposures to nonchemical stressors, and assessment of health effects associated with joint exposures to chemical and psychosocial stressors.
Traumatic Vascular Injury and its Management with Temporary Intravascular Shunts: A Puerto Rico Trauma Hospital's Experience.

OBJECTIVE Temporary intravascular shunts (TIVSs) are commonly used as a damagecontrol procedure in trauma settings. Currently, there is scarce literature in the civilian field, and what there is is limited to large trauma centers with multiple resources. Therefore, we aimed to describe TIVS usage, and the outcomes of that usage, at Puerto Rico Trauma Hospital. MATERIALS AND METHODS This is a case series conducted from 2009 to 2013 with 32 patients who suffered vascular trauma, of which 13 needed TIVSs. Data related to age, trauma mechanism, injured vessel, type of shunt, Glasgow Coma Scale, vital signs, and mortality were collected. The analysis was carried out using descriptive statistics. This protocol was approved by the IRB of the Medical Sciences Campus. RESULTS The most frequent mechanism of injury was a gunshot (11/13; 84.6%). The most commonly injured vessel was the superficial femoral artery. Indwelling time ranged from 6 to 96 hours. Only 2 of the 13 (15.4%) patients with shunts reported thrombosis. Furthermore, we performed 4 (30.7% of the patients) prophylactic fasciotomies and 4 (30.7% of the patients) amputations; 4 of the 13 (30.7%) patients died from unrelated causes. CONCLUSION Our results are consistent with those in the literature, which supports our contention that a TIVS can be an effective component of damage-control vascular surgery and can, in both military and civilian settings, aid in extremity amputation prevention. Furthermore, it has been established that a TIVS can be fashioned from any available hollow tube. However, further research is needed to evaluate the safety of an improvised catheter of this nature.
Le grand tour revisité : pour une archéologie du tourisme : le voyage des français en Italie (milieu XVIIIe siècle-début XIXe siècle)

Etape la plus emblematique du Grand Tour que les elites europeennes accomplissaient au XVIIIe siecle, le voyage en Italie ne se reduit pas a une experience de jeunes nobles completant leur education. En temps de paix comme a la faveur des guerres, des Francais de tous âges ont traverse les Alpes ou pris la mer avec les buts les plus varies. Riches ou pauvres, guides par des modeles qui canalisaient leurs attentes, ils ont contribue a transformer le visage d'une terre engagee dans le processus unitaire en inventant des capitales, comme Milan, et en parcourant les Alpes ou le Sud marque par les restes antiques. Terre des arts, de la culture classique et du catholicisme, l'Italie des Lumieres est alors devenue le «laboratoire» d'une connaissance plus systematique de la nature, des hommes et de l'organisation des societes. Mais tandis que l'encyclopedisme fit place au seuil du XIXe siecle a des savoirs plus specialises, nobles et marchands, artistes et gens de lettres renouerent avec un regard simplificateur et stereotype et le voyageur du XVIIIe siecle se mua en un touriste presse et conquerant. C'est pour mieux comprendre le passage de ces formes complexes du voyage vers le tourisme que la presente enquete s'est attachee a depouiller les guides, recits et journaux de voyage laisses par les Francais sur l'Italie entre 1750 et 1815.
The Effects of Patient Care Results of Applied Nursing Intervention to Individuals With Stoma According to the Health Belief Model.

BACKGROUND Individuals who have undergone stoma surgery take time to adjust to the stoma, and their quality of life is decreasing. OBJECTIVE The aim of this study was to examine the effects of home-based nursing interventions informed by the Health Belief Model on patient care outcomes for individuals having a stoma. METHODS This pretest, posttest, and semiexperimental design with a control group included adults who underwent a stoma operation in the previous 3 months. In total, 30 were assigned to the experimental group and 31 to the control group. Study forms included a sociodemographic questionnaire, the Stoma Quality of Life Scale, the Ostomy Adjustment Inventory, and the Pittman Complication Severity Index. RESULTS After home nursing interventions, there was a significant difference between the compliance rates of the individuals in the experimental group and the complication rates and cost averages (P < .05) with individuals in the control group; no significant difference in quality-of-life scores was found between the 2 groups. CONCLUSION In order to effectively support postoperative individuals following stoma surgery when they are released from the hospital, postdischarge follow-up care informed by the Health Belief Model components should be offered. IMPLICATIONS FOR PRACTICE We recommend creating hospital-based, home care teams that follow individuals with a stoma for at least 6 months after discharge.
Anti‐psoriatic effect of myeloid‐derived suppressor cells on imiquimod‐induced skin inflammation in mice

Myeloid‐derived suppressor cells (MDSCs) play an important role in controlling the immune response against cancer and in suppression of autoimmunity and allergic inflammation. However, the beneficial effects of MDSCs on the experimental mouse model of psoriasis have not been reported. Therefore, we investigated the anti‐psoriatic effect of MDSCs on IMQ‐induced skin inflammation in mice and explored the mechanisms involved. Our results showed that administration of MDSCs (1 × 106 or 2 × 106 cells) suppressed the development of IMQ‐induced skin inflammation in mice as exemplified by a significant reduction in clinical severity scores and was associated with a reduction of histopathological changes, including inflammatory infiltration, epidermal hyperplasia and hyperkeratosis. The immunosuppressive effect of MDSCs (1 × 106 or 2 × 106 cells) corresponded to the production of Th1 cytokines (TNF‐α, IFN‐γ) and Th17 cytokines (IL‐17A and IL‐23) in the serum and dorsal skin. Administration of MDSCs (1 × 106 or 2 × 106 cells) also inhibited splenomegaly. Moreover, an increased percentage of CD4+CD25+FoxP3+ regulatory T (Treg) cells and decreased percentage of Th1 and Th17 cells were found in mice treated with MDSCs. Taken together, these results imply that MDSCs have immunomodulatory and immunosuppressive effects on disease progression in a murine model of psoriasis and that MDSCs could be used in preventive or therapeutic strategies for the management of autoimmune inflammatory skin disorders, such as psoriasis.
Preparation and characterization of bosentan monohydrate/ε‐polycaprolactone nanoparticles obtained by electrospraying

The electrospraying technique provides nano and microparticles that can be used as drug delivery systems. The aims of this study were, firstly, to optimize the influent parameters of electrospraying for the manufacture of a Bosentan (BOS) nanoparticulate platform, and secondly, to evaluate its physicochemical properties and in vitro biopharmaceutical behavior. Particles were characterized by scanning electron microscopy (SEM), powder X‐ray diffraction (PXRD), differential scanning calorimetry (DSC), thermogravimetry (TG) and Fourier transformed Infrared spectroscopy (FTIR). Drug loading, encapsulation efficiency and kinetic dissolution were determined. Additionally, Bosentan release assays at 24 and 72 h were performed in vitro to evaluate biopharmaceutical properties of nano‐scaffolds by diffusion technique through dialysis bag. The nanostructures had heterogeneous sizes predominantly smaller than 550 nm and they were semicrystalline according to PXRD, indicating a partial amorphization of BOS during the encapsulation in the polymer matrix. FT‐IR and DSC showed an absence of chemical interactions between BOS and ε‐Polycaprolactone (PCL), suggesting that both components behaved as a physical mixture in these particles. The drug loading was 25.98%, and the encapsulation efficiency was 58.51%. Additionally, the release assays showed an extended and controlled release of BOS, in comparison to non‐encapsulated BOS. These data also showed to fit with the Cubic Root kinetic dissolution. As a conclusion, we demonstrate that the use of electrospraying for the manufacture of BOS (or similar drugs) controlled release nanoplatforms would represent an interesting contribution in the development of new therapeutic alternatives for the treatment of pathologies such as pulmonary hypertension and other related diseases. © 2018 American Institute of Chemical Engineers Biotechnol. Prog. , 35: e2748, 2019.
Azacitidine with or without lenalidomide in higher risk myelodysplastic syndrome & low blast acute myeloid leukemia

Standard treatment for higher risk myelodysplastic syndromes, chronic myelomonocytic leukemia and low blast acute myeloid leukemia is azacitidine. In single arm studies, adding lenalidomide had been suggested to improve outcomes. The ALLG MDS4 phase II trial randomized such patients to standard azacitidine or combination azacitidine (75mg/m2/d days 1 to 5) with lenalidomide (10mg days 1–21 of 28-day cycle from cycle 3) to assess clinical benefit (alive without progressive disease) at 12 months. A total of 160 patients were enrolled; median age 70.7 years (range 42.5-87.2), 31.3% female with 14% chronic myelomonocytic leukemia, 12% acute myeloid leukemia and 74% myelodysplastic syndromes. Adverse events were similar in both arms. There was excellent delivery of protocol therapy (median azacitidine cycles 11 both arms) with few dose reductions, delays or early cessations. At median follow up 33.1 months (range 0.7-59.5), the rate of clinical benefit at 12 months was 65% azacitidine arm and 54% lenalidomide+azacitidine arm (P=0.2). There was no difference in clinical benefit between each arm according to WHO diagnostic subgroup or IPSS-R. Overall response rate was 57% in azacitidine arm and 69% in lenalidomide+azacitidine (P=0.14). There was no difference in progression- free or overall survival between the arms (each P>0.12). Although the combination of lenalidomide and azacitidine was tolerable, there was no improvement in clinical benefit, response rates or overall survival in higher risk myelodysplastic syndrome, chronic myelomonocytic leukemia or low blast acute myeloid leukemia patients compared to treatment with azacitidine alone. This trial was registered at www.anzc-tr.org. au as ACTRN12610000271000.
Initial Coin Offerings and Agile Practices

An ICO (Initial Coin Offering) is an innovative way to fund projects based on blockchain. The funding is based on the selling of tokens by means of decentralized applications called smart contracts written in Solidity, a programming language specific for Ethereum blockchain. The ICOs work in a volatile context and it is crucial that the team is capable of handling constant changes. The Agile methods, proven practices enabling to develop software in presence of changing requirements, could be a means for managing uncertainty. The main goals of this work are to understand software engineering activities related to ICOs, recognize the ICOs developed using Agile methods, and make a comparison between ICOs and Agile ICOs. In addition, we perform a deeper analysis of Agile ICOs concerning project planning, software development, and code features. Our work shows that the roles of the people involved in an ICO can be compared to the typical roles of the SCRUM methodology. The majority of Agile ICOs use tool of testing before storing smart contract on blockchain. Finally, the application of volumetric and complexity software metrics shows that the files of Agile ICOs is on average shorter and less complex than in other smart contracts.
Understanding others: Emotion recognition in humans and other animals

Emotion recognition represents the ability to encode an ensemble of sensory stimuli providing information about the emotional state of another individual. This ability is not unique to humans. An increasing number of studies suggest that many aspects of higher order social functions, including emotion recognition, might be present in species ranging from primates to rodents, indicating a conserved role in social animals. The aim of this review is to examine and compare how emotions are communicated and perceived in humans and other animals, with the intent to highlight possible new behavioral approaches and research perspectives. We summarize the evidence from human emotion recognition, and latest advances in the development of nonhuman animal behavioral tests, using or implying the use of this cognitive function. The differential implication of sensory modalities used by animals to communicate and decipher emotional states is also discussed. The opportunity to measure emotion recognition abilities in rodents may allow us to better identify the neural mechanisms mediating this complex function, thus promoting the development of new intervention strategies for several neuropsychiatric disorders characterized by social cognitive dysfunctions.
High-Precision and Low-Cost Wireless 16-Channel Measurement System for Malachite Green Detection

Focusing on the issue of the malachite green traditional test methods such as large volume, high cost and high complex, this paper proposed a novel multi-channel electrochemical malachite green detection system. Specific recognition properties of malachite green DNA adapter is employed to realize accurate sensing of concentration of malachite green, which can achieve precise detection of malachite green concentration with low noise and high precision. The maximum measurement capability of multi-channel acquisition system is 16 samples in a batch. According to the experimental results, malachite green could be detected quantitatively in the range from 10−3 μg/mL to 10 μg/mL, which performs well in the test of malachite green residues in aquatic product transportation.
Global Dynamics in the Leslie-Gower Model with the Allee Effect

We complete the global bifurcation analysis of the Leslie–Gower system with the Allee effect which models the dynamics of the populations of predators and their prey in a given ecological or biomedical system. In particular, studying global bifurcations of limit cycles, we prove that such a system can have at most two limit cycles surrounding one singular point.
The Handbook of Pattern Recognition and Computer Vision

A soup dispenser is provided which will dispense liquid, semi-liquid and/or chunky soups, stews, chilis, etc., with equal facility. A motor-driven dial configuration of a plurality of measuring chambers or traps is provided at the bottom of a heated reservoir in which an impeller is constantly driven to preclude settling and scorching. The same motor drive is selectively interconnected to rotate the dial and successively register a measuring chamber with a discharge port beneath which a food container can be placed to receive the discharged product. The measuring chambers are vented to atmosphere as registry with the discharge opening is respectively effected to assure full discharge of the food product therein. A dial configuration further includes a plurality of selectively insertable strainer structures which are removably mounted flush with the upper surface of the dial over one or more of the measuring chambers to control the ratio of garnish to broth in each dispensed container of soup and the like.
Identification and editing of stem-like cells in methylcholanthrene-induced sarcomas

ABSTRACT The cancer stem cell (CSC) paradigm posits that specific cells within a tumor, so-called CSC-like cells, have differing levels of tumorigenicity and chemoresistance. Original studies of CSCs identified them in human cancers and utilized mouse xenograft models to define the cancer initiating properties of these cells, thereby hampering the understanding of how immunity could affect CSCs. Indeed, few studies have characterized CSCs in the context of cancer immunoediting, and it is currently not clear how immunity could impact on the levels or stem-like behavior of CSCs. Using the well-studied 3′methylcholanthrene (MCA) model of primary sarcoma formation, we have defined a CSC-like population within MCA-induced sarcomas as expressing high levels of stem cell antigen-1 (Sca-1) and low levels of CD90. These Sca-1+CD90− CSC-like cells had higher tumor initiating ability, could spontaneously give rise to Sca-1-negative cells, and formed more sarcospheres than corresponding non-CSC-like cells. Moreover, when examining MCA-induced sarcomas that were in the equilibrium phase of cancer growth, higher levels of CSC-like cells were found compared to MCA-induced sarcomas in the escape phase of cancer progression. Notably, CSC-like cells also emerged during escape from anti-PD-1 or anti-CTLA4 therapy, thus suggesting that CSC-like cells could evade immune therapy. Finally, we demonstrate that paradoxically, interferon (IFN)-γ produced in vivo by immune cells could promote the emergence of CSC-like cells. Our findings define the existence of a Sca1+CD90− CSC-like population in the MCA-sarcoma model capable of differentiation, tumorsphere formation, and increased tumor initiation in vivo. These cells may also act as mediators of immune resistance during cancer immunoediting and immune therapy.