Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of age on passive range of motion of selected peripheral joints in healthy adult females

The purposes of this study were to investigate whether age influences passive range of motion (PROM) in women and to compare obtained values with other available data. Ninety healthy Caucasian women from 18 to 59 years of age had the PROM of their ankle, knee, hip, shoulder, elbow, and wrist measured by using a standard goniometer. Data were analyzed by using descriptive statistics (mean/SD) and linear regression (to analyze the effect of age on ROM). Age did not significantly influence PROM for the majority of movements tested. For 11 of the tested movements (knee flexion, hip flexion, hip external rotation, glenohumeral and shoulder complex flexion, glenohumeral and shoulder complex external rotation, shoulder complex abduction, shoulder complex extension, and elbow extension), increasing age was associated with a statistically significant decrease in PROM, whereas for ankle dorsiflexion, ankle plantarflexion, ankle inversion, and hip abduction, increasing age was associated with an increase in PROM. The change in PROM associated with age was typically small and ranged from −0.420 to 0.207 degrees per year. The difference in mean PROM between this study and published normative values ranged from −16.6 to +25.9 degrees. For women aged 18 to 59, PROM of the extremities is relatively constant, suggesting that a single table of reference values for adult females is an appropriate approximation for clinical practice except for glenohumeral and shoulder complex external rotation, which were found to clinically significantly decrease with age.
Actinic keratoses

Actinic keratoses (AKs) are established as direct precursors of squamous cell carcinoma (SCC), but there is significant controversy regarding the rate at which AKs progress to SCC. The authors of this report studied a high‐risk population to estimate the risk of progression of AK to SCC and to basal cell carcinoma (BCC) and the risk of spontaneous regression of untreated AKs.
Prediction of sexual function after radical prostatectomy

Radical prostatectomy (RP) is a commonly used procedure in the treatment of clinically localized prostate cancer. For this report, the authors critically analyzed the factors associated with recovery of erectile function after surgery. A systematic review of the literature using the Medline and CancerLit databases was conducted. Keywords for the literature search included prostate cancer, radical prostatectomy, erectile dysfunction, impotence, treatment, and prophylaxis. Accurate patient selection (based on patient age, preoperative erectile function, and comorbidity profile) and adequate surgical technique (ie, the preservation of neurovascular bundles) were the major determinants of postoperative erectile function. Moreover, better results were achieved when an appropriate pharmacologic treatment using either oral or local approaches was given. Therefore, the authors concluded that, if patients are stratified correctly according to preoperative, intraoperative, and postoperative factors, then a satisfactory functional recovery may be expected after surgery. For these reasons, an ideal multivariate model predicting the restoration of erectile function after surgery should include patient, surgeon, and postsurgical treatment variables. The authors also concluded that the stratification of patients with regard to their risk of developing erectile dysfunction after surgery was feasible based on several parameters, which should be taken into account for correct patient treatment and counseling. To address this objective, accurate tools for predicting the likelihood of complete functional recovery after surgery are needed. Cancer 2009;115(13 suppl):3150–9. © 2009 American Cancer Society.
The effect of inspiratory muscle training on respiratory variables in a patient with ankylosing spondylitis: A case report

ABSTRACT Ankylosing Spondylitis (AS) presents with both musculoskeletal and cardiorespiratory pathophysiological manifestations. Inspiratory muscle training (IMT) may be a useful intervention to address deficits in respiratory and functional status. Case Description: A 25-year-old male with AS initially sought treatment for low back and right hip pain, but 7 weeks of IMT was also provided due to abnormal respiratory performance. Outcomes: At baseline, the patient presented with a resting respiratory rate (RR) of 14.5 breaths/minute, tidal volume (TV) of 0.76 L, minute ventilation (VE) of 10.87 L/min, and end tidal CO2 (PetCO2) of 30.56 mmHg. Baseline exercise test results revealed a VO2max of 44 ml/kg/min and VE to CO2 output (VE/VCO2) slope of 30. Baseline MIP, SMIP, and MEP were 54 cm H2O, 507 PTU, and 87 cm H2O, respectively, and increased to 176 cm H2O, 807 PTU, and 151 cm H2O, respectively, after IMT. The VO2max increased to 51 ml/kg/min with decreases in the VE/VCO2 slope (29), resting RR (12 breaths/minute), resting TV (0.52 L), and resting VE (6.83 L/min) after IMT. Improvements during postural challenges were also observed. Discussion: This case demonstrates the clinical utility of respiratory gas analysis and respiratory performance measures to identify functional deficits and manage a patient with AS. The improvements in respiratory performance at rest, during postural challenges, and during maximal exercise after a relatively short period of IMT highlights the role IMT may have to improve functional status in patients with AS. Further investigation of IMT in patients with AS is warranted.
Survival is poorer in patients with secondary core‐binding factor acute myelogenous leukemia compared with de novo core‐binding factor leukemia

Therapy related secondary acute myelogenous leukemia (AML) was commonly associated with prior exposure to alkylating agents or topoisomerase inhibitor. The long‐term outcome of such patients with secondary AML was found to be worse than that of patients with de novo AML. Earlier reports suggested similar outcomes for patients with de novo and secondary AML associated with core‐binding factor (CBF) abnormalities.
Exploring the teaching and learning of clinical reasoning, risks, and benefits of cervical spine manipulation

ABSTRACT The aim of this study was to examine how risks and benefits of cervical spine manipulation (CSM) were framed and discussed in the context of mentorship and their impact on the perception of safe practice of CSM in clinical physiotherapy settings. A multi-method qualitative approach was employed, including a document analysis of established educational guidelines, observations of mentoring sessions, and individual face-to-face interviews with five mentees in the process of learning CSM, and four mentors with Orthopedic Manual Physical Therapy (OMPT) certification. Results demonstrated that participants’ clinical decision-making processes to perform CSM were primarily oriented to the mitigation of risk. Achieving proficiency in the “science” of clinical reasoning and the “art” of “feel” related to mastering technical skills were viewed as means to mitigating risk and enhancing confidence to use CSM safely in clinical practice. While the “art” of technical skill mastery was of high importance to mentees and considered important to developing competency in performing CSM, it was discussed as distinct from their clinical reasoning processes. Thus, promoting a more balanced and integrated use of the “art” and “science” of safe practice for CSM in OMPT training may result in greater confidence and judicious use of CSM by physiotherapists.
Changes of aeroallergen sensitization in children with asthma or allergic rhinitis from a tertiary referral hospital in Seoul over 10 years

Results: The sensitization rates to Tree pollen mixture I and II were increased as 5.0%, 6.8% in 2000, 8.5%, 9.8% in 2005, and 14.8%, 17.3% in 2010, respectively (trend P < 0.001, P < 0.001, respectively). And the sensitization rates to D. pteronyssinus cat dander and dog dander were changed as 55%, 4.8%, 4.8% in 2000, 62.2%, 11.9%, 28% in 2005, and 63.1%, 12.7%, 16.7% in 2010, respectively. The distribution of sensitized pollens was oak (12.8%), beech (12.4%), pine (10.3%), birch (10%), hazel (9.6%), alder (8%), elder (6.9%), elm (5.4%) in the study of 2010. When allergen/histamine ratio was compared, rates of strong sensitization over 4+ to tree pollen were increased. Conclusion: The sensitization rates to inhalant allergens were increased in children with asthma or allergic rhinitis from a tertiary re- ferral hospital in Seoul over last 10 years. Especially, an increase in the degree of skin reactivity was observed in cat dander, dog dan- der, and tree pollens. The studies to investigate the etiology of this increase and prevention will be needed. (Allergy Asthma Respir Dis 2014;2:97-102)
Test–retest reliability of the unsupported upper-limb exercise test (UULEX) and 6-min peg board ring test (6PBRT) in healthy adult individuals

ABSTRACT Background: The unsupported upper-limb exercise (UULEX) and 6-min peg board ring tests (6PBRTs) have been developed to measure peak unsupported arm exercise capacity and arm endurance, respectively, in individuals with chronic obstructive pulmonary disease. These tests are valid and reproducible in this population; however, the reproducibility of healthy adults is currently unknown. Objective: To determine the within-day test–retest reliability of the UULEX and 6PBRT in healthy adults. Method: The study included 41 healthy adults, aged 38.3 ± 17.9 years old, who performed both tests, twice each on the same day, with a 30-min rest in between. Before and immediately after the tests, blood pressure (BP), heart rate (HR), perception of exertion, and arm fatigue were measured. Time to perform the test and number of rings moved were recorded for the UULEX and 6PBRT, respectively. Results: The UULEX was reproducible on Bland–Altman analysis with lower and upper limits of agreement: 2.40 and −2.49 min, respectively (bias = −0.05; p = 0.817) and intraclass correlation coefficient (ICC) = 0.85 (p < 0.0001) for time in minutes for the first and second tests. The 6PBRT was not reproducible on Bland–Altman analysis with lower and upper limits of agreement of 31.64 and −114.54 (bias = −41.45; p < 0.0001) and ICC = 0.91 (p < 0.0001) for the number of rings moved. Conclusion: UULEX is a reliable test in healthy adults. Only one test is adequate when measuring peak unsupported arm exercise capacity using the UULEX in healthy adults, while more than two tests may be needed to measure arm endurance using the 6PBRT.
Skeletal class II malocclusion correction using the Bass appliance

Skeletal class II malocclusion is best treated by growth modification using the myofunctional appliances or the orthopedic appliances or the combination of the both depending upon the type of malocclusion encountered during the growth period of an individual. Though all myofunctional appliances work on the same principle with few basic differences; the orthodontist has to make a choice among the plethora of the appliances at his disposal. The present article is a case report of class II malocclusion treatment using the Bass appliance for the growth modification, which was followed by fixed appliance for the occlusal detailing.
Complexity in simple tasks: a qualitative analysis of GPs’ completion of long-term incapacity forms

Aim To explore the factors influencing the completion of the IB113 form for the Department for Work and Pensions (DWP), as an exemplar of how general practitioners (GPs) manage and report patient information to external bodies. Background In UK, GPs complete IB113 forms for their patients approaching longer-term sickness absence, who may be exempt from the incapacity benefit linked medical examination. The DWP has expressed concerns about the quality of such reports, and GP organizations have raised objections to completing such forms. The content of returned forms is variable, and may be subject to a number of influences. Design Qualitative interviews with purposive sampling of GPs and practice managers (PMs). Setting Primary Care practices in the North East of England. Method GPs and PMs were interviewed using a semi-structured topic guide about completing IB113 forms for the DWP about their patients entering long-term incapacity. The transcribed data were analysed thematically using the framework analysis method. Results Whilst the IB113 appears superficially straightforward to complete, our results demonstrate levels of overlapping complexity that add ranges of subjectivity and selectivity onto factual reporting, including practice protocols, the gathering and managing of information, the doctor–patient relationship, and doctor’s personal views on systems. Conclusions The recording and reporting of patient related data by GPs is subject to complex influences, which need to be understood and managed to improve the relevance and quality of reports to third parties.
Pregnant women’s knowledge of obesity and ideal weight gain in pregnancy, and health behaviours of pregnant women and their partners

We conducted a survey among a convenience sample of 149 women and their partners (n = 136) attending antenatal services in the Canberra Hospital in 2010. Over one‐third (39%) of women and 63.6% of their partners were overweight/obese, and 69.2% of women had not received advice from their caregiver on their weight. Pregnant women and their partners’ health behaviours including smoking, and fruit and vegetable intake were strongly correlated (P ≤ 0.01). Pregnant women require targeted advice on their weight, ideal weight gain and impact of these on pregnancy.
Dasatinib or high‐dose imatinib for chronic‐phase chronic myeloid leukemia resistant to imatinib at a dose of 400 to 600 milligrams daily

In patients with chronic‐phase chronic myeloid leukemia (CP‐CML), imatinib resistance is of increasing importance. Imatinib dose escalation was the main treatment option before dasatinib, which has 325‐fold more potent inhibition than imatinib against unmutated Bcr‐Abl in vitro. Data with a minimum of 2 years of follow‐up were available for the current study of dasatinib and high‐dose imatinib in CP‐CML resistant to imatinib at daily doses from 400 mg to 600 mg.
Clinical characteristics of 45 patients with invasive pulmonary aspergillosis

Invasive aspergillosis (IA) is a common complication in patients with hematologic malignancies. Patients with solid tumors also are at risk for IA because they may develop neutropenia as a result of chemotherapy and radiotherapy. However, studies of IA in patients with solid tumors are rare. In this study, the risk factors and clinical characteristics of pulmonary infection and death mediated by invasive pulmonary aspergillosis (IPA) as complications in patients with lung cancer were determined.
SAFETY OF CONSECUTIVE SAME-DAY BILATERAL INTRAVITREAL DEXAMETHASONE IMPLANT (OZURDEX).

PURPOSE The objective of this study was to evaluate patient safety and tolerance of consecutive bilateral intravitreal dexamethasone (Ozurdex) injections during a single visit for the treatment of cystoid macular edema secondary to retinal vein occlusion, diabetic macular edema, or noninfectious posterior uveitis. METHODS This was a retrospective single-center institutional review board-approved study from March 1, 2013, through August 1, 2016. All patients had a complete ophthalmologic examination and optical coherence tomography imaging. Bilateral intravitreal dexamethasone (Ozurdex) injection was performed according to standard sterile procedure. Twelve patients (24 eyes) were included in the study. RESULTS A total of 48 injections were administered to 24 eyes of 12 patients that qualified for the study. Patients received intravitreal dexamethasone (Ozurdex) injections for treatment of diabetic macular edema (10 patients), retinal vein occlusion (1 patient), or noninfectious posterior uveitis (1 patient). There were no complications. CONCLUSION Consecutive same-day bilateral intravitreal dexamethasone (Ozurdex) is safe and well tolerated. There were no significant complications, and patients preferred continuing bilateral implantation after their initial trial. Same-day treatment may optimize efficiency and decrease patient visits and ultimate treatment burden without compromising patient safety or clinical efficacy.
Rehabilitating Phineas Gage

The view that Phineas Gage's accident made him permanently “no longer Gage” is scrutinised critically. Re-examination of the well-known older evidence together with a consideration of new material strongly implies that Gage eventually made a surprisingly good psychosocial adaptation to his injury. It is argued that the structure provided by the external circumstances of his work facilitated this result. Parallels are drawn with the theory and practice of modern rehabilitation which began with Luria.
Multicentre population‐based dementia prevalence survey in Japan: a preliminary report

Community‐based surveys were performed in seven rural areas in Japan to investigate the prevalence of dementia and illnesses causing dementia. A total of 5431 elderly subjects were selected based on census data from 1 October 2009. In total, 3394 participants were examined (participation rate: 62.5%), and 768 dementia cases and 529 mild cognitive impairment cases were identified. Of the illnesses causing dementia, Alzheimer's disease was the most frequent (67.4%), followed by vascular dementia (18.9%), dementia with Lewy body disease (4.6%), mixed dementia (4.2%) and other illnesses. The prevalence of dementia according to 5‐year age strata between 65 and 99 years was 5.8–77.7% among the participants. The prevalence of dementia in this study was higher than in previous reports in Japan and other countries. To verify the upward trend of dementia prevalence and its background factors, we have scheduled surveys for three other urban areas in 2011–2012.
The relationship between the diagnosis method of neuronal dysfunction (DIMENSION) and brain pathology in the early stages of Alzheimer's disease

To examine whether the diagnosis method of neuronal dysfunction (DIMENSION), a new electroencephalogram (EEG) analysis method, reflected pathological changes in the early stages of Alzheimer's disease (AD), we conducted a comparative study of cerebrospinal fluid markers and single‐photon emission computed tomography.
Modulation of motor learning and memory formation by non-invasive cortical stimulation of the primary motor cortex

Transcranial magnetic (TMS) and direct current (tDCS) stimulation are non-invasive brain stimulation techniques that allow researchers to purposefully modulate cortical excitability in focal areas of the brain. Recent work has provided preclinical evidence indicating that TMS and tDCS can facilitate motor performance, motor memory formation, and motor skill learning in healthy subjects and possibly in patients with brain lesions. Although the optimal stimulation parameters to accomplish these goals remain to be determined, and controlled multicentre clinical studies are lacking, these findings suggest that cortical stimulation techniques could become in the future adjuvant strategies in the rehabilitation of motor deficits. The aim of this article is to critically review these findings and to discuss future directions regarding the possibility of combining these techniques with other interventions in neurorehabilitation.
The Working Memory Questionnaire: A scale to assess everyday life problems related to deficits of working memory in brain injured patients

The objective of the present study was to develop a scale designed to assess the consequences of working memory deficits in everyday life. The Working Memory Questionnaire (WMQ) is a self-administered scale, addressing three dimensions of working memory: short-term storage, attention, and executive control. The normative sample included 313 healthy participants. The patient group included 69 brain injured patients, who were compared to a subsample of 69 matched healthy controls. The questionnaire was found to have a good internal consistency, both in healthy participants and in patients with brain injury (Cronbach's alpha = .89 and .94, respectively). In healthy participants, significant effects of age (p < .0001) and education (p < .01) were found, due to more complaints in participants aged 60 or more and (unexpectedly) in those aged below 30, and for less educated participants, below high school level. The WMQ was found to have the sensitivity to discriminate patients from matched controls, in the three domains (p < .0001). A good concurrent validity was found with the Cognitive Failure Questionnaire and the Rating Scale of Attentional Behaviour (Spearman's Rho = .90 and .81, respectively, both ps < .0001). In addition, the total complaint score significantly correlated with neuropsychological measures of working memory (visual spans and short-term memory with interference) and with global intellectual efficiency (Raven's Matrices) but not with digit spans. Further studies are needed to measure the internal structure of the scale, and to compare self- and proxy-ratings.
Evaluation of Hematological Parameters in Caprine Besnoitiosis

Abstract Nazifi, S. , Oryan, A. and Mohebbi, H. 2002. Evaluation of hematological parameters in caprine besnoitiosis. J. Appl. Anim. Res., 21: 123–128. To evaluate the hematological parameters in caprine besnoitiosis, blood samples from 24, each infected with severe besnoitiosis as well as normal goats, were compared. To identify the besnoitia positive goats, biopsies and tissue samples were taken from mid region of the skin of the right tarsal and carpal joints of the goats that showed symptoms of besnoitiosis. Red blood cells, lymphocytes count, hemoglobin concentration and hematocrit values of the infected goats were significantly (P<0.05) lower and mean corpuscular volume (MCV), Mean corpuscular hemoglobin (MCH), white blood cells, neutrophils, eosinophils, monocytes and basophils counts were significantly (P>0.05) higher as compared to those of normal ones. Severity of infection effected differences in some of these parameters.
The factorial and discriminant validity of the German version of the Post-traumatic Growth Inventory in stroke patients

Post-traumatic growth (PTG) is the experience of positive changes that can follow a traumatic event. The current study examined the factorial as well as the discriminant validity of the German version of the Post-traumatic Growth Inventory (PTGI-G) in stroke patients. A total of 188 adult stroke patients (63.3% male; median age 69 years) completed the PTGI-G and the German version of the Hospital Anxiety and Depression Scale (HADS-D) at the end of their inpatient rehabilitation. Confirmatory factor analyses indicate an acceptable model fit of both the original five-factor solution as well as a second-order factor model of the PTGI-G (CFI > .95; RMSEA < .01). Small and non-significant correlations between the PTGI-G subscales and the depression scale of the HADS-D support the discriminant validity of the PTGI-G. The PTGI-G appears to be a valid tool in the context of stroke research.