Miracle-dz/UniFAR-FTUs huggingface dataset:
How can the discourses of autistics be articulated andlegitimated to create spatial design criteria for indoorand outdoor space

Many people on the autistic spectrum have major sensory processing issues. In order to research this area for my PhD – specifically the issue of design in the built environment that takes account of the sensory difficulties experienced by autistic people – I needed, as a preliminary exercise in this MRes, to examine methods of accessing the views and requirements of autistic people. I had intended for my later doctoral research to employ focus groups. Implicit in this method however is the danger of influence on the data by the researcher and more articulate members of the group. To attempt to overcome this I have looked into a range of alternative methods in this thesis, and in particular critical methodologies including the concept of ‘the hyphen’ and ethnodrama. In this work, I have piloted the use of one of these methods, ethnodrama, taking the part of a middle-aged, autistic woman with visual, motor, and social impairments in a walk around a London suburb. My main finding concerned the difficulty of conducting simultaneous motor and verbal activity. I have found this a useful and productive pilot, resulting in my being more open to autistic perceptions and experience of space.
Coupling of stratospheric warmings with mesospheric coolings in observations and simulations

AbstractThe vertical coupling between the stratosphere and the mesosphere is diagnosed from polar cap temperatures averaged over 60°–90°N with a new method: the joint occurrence of a warm stratosphere at 10 hPa and a cold mesosphere at 0.01 hPa. The investigation of an 11-yr-long dataset (2004–15) from Aura-MLS observations shows that such mesospheric coupling days appear in 7% of the winter. During major sudden stratospheric warming events mesospheric couplings are present with an enhanced average daily frequency of 22%. This daily frequency changes from event to event but broadly results in five of seven major warmings being classified as mesospheric couplings (2006, 2008, 2009, 2010, and 2013). The observed fraction of mesospheric coupling events (71%) is compared with simulations of the Kuhlungsborn Mechanistic Circulation Model (KMCM), the Hamburg Model of the Neutral and Ionized Atmosphere (HAMMONIA), and the Whole Atmosphere Community Climate Model (WACCM). The simulated fraction of mesospheric cou.
Two years follow up study of post placental insertion of IUCD during caesarean sections: safety, efficacy and complications

Post placental insertion of IUCD (PPIUCD) has been recommended by WHO to be safe, effective, reversible and immediate method of contraception. This is the time when parturient is highly motivated for effective contraception. In developing country like India where women are still not fortunate enough to get medical services easily, this is the time when most of them come in contact with the trained medical personnel.
The effects of country-level population policy for enhancing adaptation to climate change

The effectiveness of population policy in reduc- ing the combined impacts of population change and climate change on water resources is explored. One no-policy sce- nario and two scenarios with population policy assumptions are employed in combination with water availability under the SRES scenarios A1b, B1 and A2 for the impact analysis. The population data used are from the World Bank. The river discharges per grid of horizontal resolution 0.5 are obtained from the Total Runoff Integrating Pathways (TRIP) of the University of Tokyo, Japan. Unlike the population scenarios utilized in the SRES emission scenarios and the newest rep- resentative concentration pathways, the scenarios employed in this research are based, even after 2050, on country-level rather than regional-level growth assumptions. Our analysis implies that the heterogeneous pattern of pop- ulation changes across the world is the dominant driver of water stress, irrespective of future greenhouse gas emissions, with highest impacts occurring in the already water-stressed low latitudes. In 2100, Africa, Middle East and parts of Asia are under extreme water stress under all scenarios. The sen- sitivity analysis reveals that a small reduction in popula- tions over the region could relieve a large number of people from high water stress, while a further increase in population from the assumed levels (SC1) might not increase the num- ber of people under high water stress considerably. Most of the population increase towards 2100 occurs in the already water-stressed lower latitudes. Therefore, population reduc- tion policies are recommended for this region as a method of adaptation to the future water stress conditions. Popula- tion reduction policies will facilitate more control over their future development pathways, even if these countries were not able to contribute significantly to greenhouse gas (GHG) emission cuts due to economic constraints. However, for the European region, the population living in water-stressed re- gions is almost 20 times lower than that in the lower latitudes. For countries with high population momentum, the pop- ulation policy scenario with fertility-reduction assumptions gained a maximum of 6.1 times the water availability in Niger and 5.3 times that in Uganda compared with the no- policy scenario. Most of these countries are in sub-Saharan Africa. These countries represent 24.5 % of the global pop- ulation in the no-policy scenario, and the scenario with fertility-reduction assumptions reduces it to 8.7 % by 2100. This scenario is also effective in reducing the area under ex- treme water stress in these countries. However, the policy scenario with assumptions of population stabilization at the replacement fertility rate increases the water stress in high- latitude countries. Nevertheless, the impact is low due to the high per capita water availability in the region. This research is expected to widen the understanding of the combined im- pacts of climate change in the future and of the strategies needed to enhance the space for adaptation.
The changing face of Islam

In cultural studies discourse theory is often used. Remarkably, the politically oriented work of Laclau & Mouffe has hardly been used whilst it is extremely useful for researching culture: Laclau & Mouffe can indeed be helpful to research media, conflict, and identity (politics). Their discourse theory (and that of others) can be seen as a ‘toolbox’ that can be combined with qualitative research methods. I agree with the concept of the ‘toolbox’ but argue that the complexity of combining Laclau & Mouffe with other research methods and theories within cultural studies requires the formulation of the conditions under which this is possible. I shall discuss these conditions and expand on the relationship between Laclau and Mouffe and cultural studies research. I do so by analysing the representation of Ayatollah Khomeini in Western television news from 1978 through 1989. In Western eyes Khomeini is a powerful even threatening individual: in his rational treatment he appears to have control of irrationality (in the form of ‘irrational’ masses). And irrationality is something that in Western culture is experienced as very threatening. Khomeini has, in Western perspective, the power over threatening irrationality. And that makes him all the more terrifying: he is represented as an ’antagonist’ of great proportion because he is able to both unleash and master the irrational.
Mirror, Mirror on the Wall: Prospective Mathematics and Science Teachers’ Use of Metaphors to Conceptualize and Understand Reflective Thinking

Abstract The aim of this study is to investigate prospective teachers’ use and conceptualization of metaphors on reflective thinking. This study analyses the metaphorical conceptions of reflective thinking concepts of 71 PTs in a course on “Principles and Methods in Instruction”. Metaphors produced regarding reflective thinking fall under 9 categories and a total of 62 metaphors were produced. Most frequently used metaphors were those of “mirror” and “machine”.
Factors determinate customer shopping behaviour through Internet: the Malaysian case

3 Abstract: This study try to explore factors that are affect shopping behaviour of the customer, how does Internet marketing affect the behaviour of the customer. Factor analysis is used in this study to identify the salient attributes that have impact on consumers' shopping behaviour about Internet marketing. Since, Factor analysis represents an analytical process of transforming statistical data (as measurements) into linear combinations of variables. In addition, multiple regression model was estimated to anticipate the effects of the explanatory variables. Findings of regression analysis indicated taht all four factors such as Internet marketing environment, product characteristics, familiarity and confidence and promotional offer have significant impact on customer intention about Internet marketing. In conclution, underlying uncertainty of customers as to the security of transaction on the Internet. Customers may not yet be ready for the transactional purposes due to security concern and mentally afraid doing transaction online due to security reason. They believe that online transactions are not secured enough to protect the payment method as disclosure of information.
Critical assessment of risk-taking behavior and economic performance of male entrepreneurs in the Centurion central business district in South Africa

According to Zinkhan and Karande (1990), risk is encountered when an individual’s action produces social and economic consequences that cannot be projected with certainty. Zinkhan and Karande (1990) also see risk averseness as the propensity to avoid taking risks and are generally conceived as a personality variable. Levitt (1990) argues that the ways in which business managers handle risk can markedly affect economic performance and the standard of living in various societies. It was, thus, imperative that this study coupled risk-taking ability with economic performance amongst male entrepreneurs in Centurion. The entrepreneurial phenomenon remains a widely researched topic. Extensive research with regards to the attributes of entrepreneurs has been done in the recent past. It has, thus, become important to better understand South African entrepreneurial behavior, as not many local studies has been done on the topic. The purpose of this study is to establish whether the identified factors affect the risk taking behavior of male entrepreneurs within the Centurion CBD. The risk-taking behavior of male entrepreneurs versus their economic performance was also investigated. By gaining an understanding of the risk taking behavior of the population, recommendations for future studies could be made. This study is based on a deductive approach to establish possible factors which might affect the risk-taking behavior of male entrepreneurs within the Centurion central business district. It also investigates the relationship between their risk-taking behavior and their economic performance. The researcher established possible factors from the literature and adopted and modified the DOSPERT scale developed by Weber, Blais and Betz (2002). Quantitative data were obtained within the population of 161 respondents. The results indicate a strong correlation between the factors identified and the risk-taking behavior of the entrepreneurs, except for the factor ethnic background. It was also found that a strong relationship exists between risk-taking behavior and economic performance.
Lysosomal perturbations in dopaminergic neurons derived from induced pluripotent stem cells with PARK2 mutation

Mutations in the PARK2 gene encoding parkin, an E3 ubiquitin ligase, are associated with autosomal recessive early-onset Parkinson’s disease (PD). While parkin has been implicated in the regulation of mitophagy and proteasomal degradation, the precise mechanism leading to neurodegeneration in both sporadic and familial PD upon parkin loss-of-function mutations remains unknown. Cultures of isogenic induced pluripotent stem cell (iPSC) lines with and without PARK2 knockout (KO) enable mechanistic studies of the effect of parkin deficiency in human dopaminergic neurons. In the present study, we used such cells to investigate the impact of PARK2 KO on the lysosomal compartment combining different approaches, such as mass spectrometry-based proteomics, electron microscopy (TEM) analysis and functional assays. We discovered a clear link between parkin deficiency and lysosomal alterations. PARK2 KO neurons exhibited a perturbed lysosomal morphology, displaying significantly enlarged and electron-lucent lysosomes as well as an increased total lysosomal content, which was exacerbated by mitochondrial stress. In addition, we found perturbed autophagic flux and decreased lysosomal enzyme activity suggesting an impairment of the autophagy-lysosomal pathway in parkin-deficient cells. Interestingly, activity of the GBA-encoded enzyme, β-glucocerebrosidase, was significantly increased suggesting the existence of a compensatory mechanism. In conclusion, our data provide a unique characterization of the morphology, content, and function of lysosomes in PARK2 KO neurons, thus revealing a new important connection between mitochondrial dysfunction and lysosomal dysregulation in PD pathogenesis.
Relationship of Oral Health Literacy with Dental Caries and Oral Health Behavior of Children and Their Parents

Objectives: This study sought to assess the relationship of oral health literacy (OHL) of parents with the decayed, missing, and filled teeth (DMFT) indices of themselves and their children. Materials and Methods: This cross-sectional study was performed on 258 children presenting with their parents to the Pediatric Dentistry and Orthodontics Departments of School of Dentistry, Tehran University of Medical Sciences in 2016. The parents were asked to fill out questionnaires related to OHL, oral health behaviors, and background information. Both parents and children were clinically examined to determine their DMFT indices according to the World Health Organization (WHO) criteria. A backward linear regression model was applied to assess the effect of demographic factors on OHL, behavioral habits, and DMFT. The Pearson’s bivariate correlation was used to assess the relationship of OHL, behavioral habits, and DMFT. Results: A significant linear correlation was noted between the OHL of the parents and the number of filled teeth in children (P=0.01). Only 48.5% of the parents had adequate OHL. Children whose parents had adequate OHL had a significantly higher number of fillings (P=0.03) and fewer missing teeth (P=0.04). Children whose parents had inadequate or marginal OHL had a significantly lower number of fillings (P=0.01) and more missing teeth (P=0.03). Conclusions: Higher OHL of parents seems to be significantly related to the mean DMFT of themselves and their children and enhances their oral health behavior. Programs must be implemented in developing countries, including Iran, to promote the OHL of parents and consequently improve the oral health status of children.
Influence of Intellectual Capital and Dividend Policy on the Investment Opportunity Set And The Company Intrinsic Value In The Foreign Capital Companies Indonesia Stock Exchange

This study aims to analyze the influence of intellectual capital and dividend policy on the company intrinsic value with investment opportunity as intervening variable. Intellectual capital is proxied with Value Added Intellectual Capital (VAIC TM ), dividend policy is proxied with dividend yield, Investment Opportunity Set (IOS) is proxied with market to book asset ratio and intrinsic value of company is proxied with net present value from projection of Free Cash Flow to Firm (FCFF). The sample in this research is 31 Foreign Capital Investment companies in 2015. The result of research at first substructure at alpha 5%, indicate that intellectual capital have a significant positive effect and dividend policy has significant negative effect to investment opportunity set. Intellectual capital and dividend policy simultaneously affect the investment opportunity set. The second substructure research results at alpha 5%, indicating that intellectual capital and investment opportunities set have a significant positive effect on the intrinsic value of the company, but dividend policy has no effect and insignificant to the intrinsic value of the company. In addition, the three variables simultaneously affect the intrinsic value of the firm. So from the results of the study as a whole showed that intellectual capital directly and indirectly affect the intrinsic value of the company; Dividend policy only has an indirect effect on intrinsic value of the company. Keywords : intellectual capital, dividend policy, investment opportunity set, intrinsic value of company.
Perspectives of secretome proteomics in filamentous fungi.

Filamentous fungi are eukaryotic protein factories having greater relevance in the modern day food and pharmaceutical industries. They are known for their astounding potential towards biodegradation and mineralization of xenobiotics and lignocellulosics. This unique Kingdom of organisms play an inevitable role in environmental cleanup and make up, adapting themselves by way of regulating their bound and secretary proteins. They make changes in the proteome composition and provide exciting opportunities in food, feed, biofuel, pharmaceutical and agroindustries. Overview of proteomic strategies in filamentous fungi with respect to extracellular proteomes, enzymes or secretomes will have greater relevance to understand the bio-based processes, such as biomass deconstruction and mycoremediation, wherein fungi are primarily involved. Scientists of “Proteogenomics Era” try to use customized protein sequence databases to identify novel peptides in filamentous fungi. Proteomics techniques can help to elucidate complex biological processes and are considered as powerful tools for the sensitive detection and rapid identification of filamentous fungi through protein expression understanding the interaction between fungal pathogen and host plant is more challenging. The expression of protein profiles in such cases is much complicated due to the presence of proteomes of two different species simultaneously, either at the infection court or at a remote place inside the partnering organisms. When the plant and its associated fungal biome is subjected to genomic analysis, the power of proteomics remains to be the chosen tool to unravel the molecular pathways of pathogencity and resistance. Sometimes, in a compatible partnership like in mycorrhiza, the proteomics tools and techniques help to understand the symbiotic relationship. Experimental designs have also progressed extensively towards organelle proteomics and the knowledge on localization of proteins is of overriding importance to understand functions of various proteins at sub-cellular level. Organelle proteomics has gained insights in to compartmentalization and localization that exists in a fungal cell with respect to protein secretomes (e.g. production and process control of antibiotics, organic acids, enzymes etc.,). Bioinformatics tools can help in the quantitative and qualitative estimation of such proteins to look beyond harnessing the full potential of filamentous fungi.
The Structure and Function of SerumOpacity Factor : A Unique Streptococcal Virulence Determinant That Targets High-Density Lipoproteins

Serum opacity factor (SOF) is a virulence determinant expressed by a variety of streptococcal and staphylococcal species including both human and animal pathogens. SOF derives its name from its ability to opacify serum where it targets and disrupts the structure of high-density lipoproteins resulting in formation of large lipid vesicles that cause the serum to become cloudy. SOF is a multifunctional protein and in addition to its opacification activity, it binds to a number of host proteins that mediate adhesion of streptococci to host cells, and it plays a role in resistance to phagocytosis in human blood. This article will provide an overview of the structure and function of SOF, its role in the pathogenesis of streptococcal infections, its vaccine potential, its prevalence and distribution in bacteria, and the molecular mechanism whereby SOF opacifies serum and how an understanding of this mechanism may lead to therapies for reducing high-cholesterol concentrations in blood, a major risk factor for cardiovascular disease.
Effects of entomopathogenic fungi used as plant inoculants on plant growth and pest control

Effects of entomopathogenic fungi used as plant inoculants on plant growth and pest control Entomopathogenic fungi (EPF) of the genera Metarhizium and Beauveria are able to endophytically colonize a wide variety of plant species, providing protection against arthropod pests; besides increasing the plant development; and act as phytopathogen antagonists. The main objective of the present project was to evaluate the potential of entomopathogenic fungi as plant inoculants against the two-spotted spider mite Tetranychus urticae and the effects on plant growth promotion. Tritrophic effects were also studied, by evaluating prey consumption and feeding behavior of the predatory mite Phytoseiulus persimilis. The evaluated strategy has several potential benefits compared to the sole use of EPF as contact biocontrol agents, as it may control both pests and phytopathogens; be compatible with other natural enemies; provide limited exposure of fungal propagules to adverse environmental conditions, and accelerate seed emergence and plant growth. Considering this, the effects of seed inoculation using two isolates of Metarhizium robertsii and Beauveria bassiana were evaluated at University of Copenhagen, Denmark, on plant development (i.e. biomass and yield) and T. urticae population growth in a model system with bean plants under greenhouse conditions. Effects on feeding performance of P. persimilis were also studied in laboratory conditions. In Brazil, inoculation studies with EPF were conducted at ESALQ/USP with strawberry plants in greenhouse conditions and in the field in four commercial production areas of strawberries in Atibaia-SP and Senador Amaral-MG. In greenhouse studies, the effects of 15 isolates of Metarhizium spp. , 5 isolates of B. bassiana and 5 of Cordyceps (= Isaria) fumosorosea were studied, whereas in the commercial area one isolate of Metarhizium and Beauveria was used. Strawberry roots were inoculated by submersion in fungal suspensions, and the population growth of spider mites, while plants development was assessed by measuring root lengths, biomass of roots and leaves, and the strawberry fruit weight. The results showed a significant reduction in T. urticae population and in general better plant development in both crops. The production of string beans and strawberry fruits were higher in inoculated plants than in non-inoculated plants. There was no difference in predation rate and feeding behavior of the predator mite P. persimilis towards T. urticae from fungal inoculated and uninoculated plants. In the commercial strawberry production areas there were significantly lower populations of T. urticae and fewer symptoms of plant diseases on plants in the fungal treated beds compared to plants in untreated beds. The results of this project bring a new perspective on the use of Metarhizium and Beauveria as plant protecting agents revealing that the use of entomopathogenic fungi as plant inoculants may be a promising strategy.
Tilburg University Strategy based segmentation of industrial markets

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