Miracle-dz/UniFAR-FTUs huggingface dataset:
Urban Land Extraction Using DMSP/OLS Nighttime Light Data and OpenStreetMap Datasets for Cities in China at Different Development Levels

Nighttime light (NTL) and OpenStreetMap (OSM) have been used increasingly to delineate boundaries between urban and nonurban areas. However, systematic comparisons of how well such data can be used for identifying urban land for cities with different development levels are extremely limited. In this study, NTL data from the Defense Meteorological Satellite Program/Operational Linescan System, road data and points-of-interest data from the OSM are carefully selected as main data sources, and further applied for urban land extractions from Chinese cities at different development levels. Approaches being adopted for extractions include the support vector, optimal threshold, sudden-jump, head/tail break, and densi-graph methods. Results show that the overall accuracy of urban land extracted from OSM data is significantly higher than that from NTL data. Averaged overall accuracies (AOAs) of urban land extractions from OSM data are 90%, while AOAs from NTL data are only 76%. Accuracies of urban land extractions experience a decline during increasing city development levels. Averaged balanced accuracies (ABAs) for high-developed cities are the lowest (about 65%), while ABAs for mid- and low-developed cities are comparable (71% and 72%, respectively). Also, significant differences between accuracies of urban land extractions by different methods are not observed in this case. Further, it is suggested that OSM is a robust data source for extracting urban land from cities at different development levels.
Neonicotinoid insecticide hydrolysis and photolysis: Rates and residual toxicity.

Neonicotinoid insecticides are the most widely used class of insecticides worldwide. Concern has grown over their widespread environmental presence and potential unintended adverse effects. The present study examined hydrolysis and photolysis reaction rates of neonicotinoids and assessed any residual toxicity of reaction products. Hydrolysis rates were tested between pH 4 and 10 and found to be base-catalyzed. Experiments revealed a nonelementary rate law for hydrolysis, with the hydroxide concentration raised to a power of 0.55 ± 0.09, which has implications for accurate prediction of environmental half-lives. Divalent metal ions (Cu2+ , Ni2+ , Zn2+ ) and minerals (kaolinite, goethite, TiO2 ) had no effect on hydrolysis rates. The hydrolysis rate in a natural water, however, was slower than that predicted by buffered experiments. Nitenpyram, imidacloprid, thiamethoxam, and clothianidin reacted via direct photolysis in both ultrapure and natural waters, with average quantum yields of 0.024 ± 0.001, 0.0105 ± 0.0002, 0.0140 ± 0.0002, and 0.0101 ± 0.0001, respectively. Acetamiprid primarily underwent indirect photolysis by reaction with OH· (1.7 ± [0.2] × 109 M-1 s-1 ). For all compounds, the urea derivative was the most commonly detected product in both hydrolysis and photolysis experiments. Using mosquito (Culex pipiens) larvae, no residual toxicity of reaction products was observed. Results indicate long environmental half-lives for the tested neonicotinoids, which may help to explain their ubiquitous presence in environmental matrices. Environ Toxicol Chem 2018;37:2797-2809. © 2018 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals, Inc. on behalf of SETAC.
Development of Modified Spherical Signature Descriptor for Robust Object Recognition Using 3D Point Cloud Data via CNN

This paper presents the novel observation model, called Modified Spherical Signature Descriptor (MSSD), capable of representing 2D image generated from 3D point cloud data. The Modified Spherical Signature Descriptor has a uniform mesh grid to accumulate the occupancy evidence caused by neighbor point cloud data. According to a kind of area such as wall, road, tree, car, and so on, the evidence pattern of 2D image looks so different each other. For the parameter learning of Convolutional Neural Network (CNN) layers, these 2D images were applied as the input layer. The Convolutional Neural Network, one of the deep learning methods and familiar with the image analysis, was utilized for the urban structure classification. The case study on CNN practice was introduced in this study. The simulation results shows that the classification accuracy of CNN with 2D images of the proposed MSSD was improved more than the traditional methods' one.
On-Demand Therapy with Proton Pump Inhibitors for Maintenance Treatment of Nonerosive Reflux Disease or Mild Erosive Esophagitis: A Systematic Review and Meta-Analysis

Background Proton pump inhibitors (PPIs) are widely used for the long-term management of gastroesophageal reflux disease (GERD). However, concerns about the cost and/or inconvenience of continuous maintenance PPI treatment have led to the evaluation of various alternative approaches. Aim To assess the effectiveness of on-demand PPI therapy in the maintenance treatment of nonerosive reflux disease (NERD) or mild erosive esophagitis (EE). Methods We searched MEDLINE, EMBASE, Web of Science, and Cochrane Library from inception until October 2, 2017, for randomized controlled trials (RCTs) comparing on-demand PPI versus placebo or daily PPI in the management of NERD or mild EE (Savary-Miller grade 1). Discontinuation of therapy during the trial was used as a surrogate for patient dissatisfaction and failure of symptomatic control. We calculated pooled odds ratios (OR) to evaluate the efficacy of on-demand PPI treatment. Separate analyses were conducted for studies comparing on-demand PPI with daily PPI and with placebo. Subgroup analysis was done based on NERD studies alone and on studies of both NERD and mild EE. These were analyzed using a random effects model. Results We included 10 RCTs with 4574 patients. On-demand PPI was superior to daily PPI (pooled OR = 0.50; 95% confidence interval (CI) = 0.35, 0.72). On subgroup analysis in NERD patients only, pooled OR was 0.44 (0.29, 0.66). In studies including patients with NERD and mild EE, pooled OR was 0.76 (0.36, 1.60). For studies comparing on-demand PPI with placebo, pooled OR was 0.21 (0.15, 0.29); subgroup analyses of studies evaluating NERD only and studies conducted in NERD and mild EE showed similar results (pooled OR was 0.22 (0.13, 0.36) and 0.18 (0.11, 0.31), resp. ). Conclusions On-demand PPI treatment is effective for many patients with NERD or mild EE. Although not FDA-approved, it may be adequate for those patients whose symptoms are controlled to their satisfaction.
Immunohistochemical expression of extracellular matrix metalloproteinase inducer (EMMPRIN) in normal oral mucosa, oral epithelial dysplasia and oral squamous cell carcinoma

Background: In oral squamous cell carcinoma (OSCC), extracellular matrix metalloproteinase inducer (EMMPRIN) expression has been noted in the cell membrane throughout the epithelium of the lesion, suggesting its increased expression. Objectives: The present study was conducted to evaluate and compare the expression of EMMPRIN in the normal oral mucosa (NOM), different histological grades of oral epithelial dysplasia (OED) and OSCC. Materials and Methods: A total of 100 formalin-fixed paraffin-embedded tissue blocks of NOM (n = 10), 20 cases each of mild, moderate and severe (OED) (n = 60), and 10 cases each of well differentiated, moderately differentiated and poorly differentiated carcinomas (n = 30) were included in the study. The tissues sections were immunohistochemically stained and were evaluated for intensity and area of expression in different groups. Results: Out of 60 cases of OED, 29 (48%) cases showed intense dark brown staining in the epithelium. The stroma in 38 (63%) cases showed positive immunoexpression. The expression of EMMPRIN in OSCC revealed intense dark brown staining in 9 (90%) cases of well differentiated, and a decent thereon in 8 (80%) cases of moderately differentiated and 4 (40%) cases of poorly differentiated carcinomas. Conclusion: The role of EMMPRIN in precarcinogenesis and early carcinogenesis needs to be studied on considerable sample size. This can enable oncologists to detect cancer at an early stage before it progresses to malignancy.
“Life never matters in the DEMOCRATS MIND”: Examining strategies of retweeted social bots during a mass shooting event

This exploratory study examines the strategies of social bots on Twitter that were retweeted following a mass shooting event. Using a case study method to frame our work, we collected over seven million tweets during a one‐month period following a mass shooting in Parkland, Florida. From this dataset, we selected retweets of content generated by over 400 social bot accounts to determine what strategies these bots were using and the effectiveness of these strategies as indicated by the number of retweets. We employed qualitative and quantitative methods to capture both macro‐ and micro‐level perspectives. Our findings suggest that bots engage in more diverse strategies than solely waging disinformation campaigns, including baiting and sharing information. Further, we found that while bots amplify conversation about mass shootings, humans were primarily responsible for disseminating bot‐generated content. These findings add depth to the current understanding of bot strategies and their effectiveness. Understanding these strategies can inform efforts to combat dubious information as well as more insidious disinformation campaigns.
Effectiveness of Art Therapy With Adult Clients in 2018—What Progress Has Been Made?

In the year 2000, an important art therapy literature review addressed an essential question—does art therapy work? It discussed 17 articles dealing with the issue of the effectiveness of art therapy. Two decades later, this research field has extended its scope and is flourishing. Several current reviews of research work have described the broad range of methods implemented today, which includes qualitative and quantitative studies; other reviews have focused on art therapy with specific populations, or by age group. The aim of this systematic literature review is to contribute to the ongoing discussion in the field by exploring the latest studies dealing with the effectiveness of art therapy with a broad scope of adult clients. We conducted a comprehensive search in four databases and review of every quantitative article that has addressed outcome measures in the art therapy field from 2000 to 2017. This paper presents the latest 27 studies in the field that examine the effectiveness of art therapy with adult clients and divides them into seven clinical categories: cancer patients, clients coping with a variety of medical conditions, mental health clients, clients coping with trauma, prison inmates, the elderly, and clients who have not been diagnosed with specific issues but face ongoing daily challenges. It underscores the potential effects of art therapy on these seven clinical populations, and recommends the necessary expansions for future research in the field, to enable art therapy research to take further strides forward.
Hybrid Processing Design for Multipair Massive MIMO Relaying With Channel Spatial Correlation

Massive multiple-input multiple-output (MIMO) avails of simple transceiver design which can tackle many drawbacks of relay systems in terms of complicated signal processing, latency, and noise amplification. However, the cost and circuit complexity of having one radio frequency (RF) chain dedicated to each antenna element are prohibitive in practice. In this paper, we address this critical issue in amplify-and-forward (AF) relay systems using a hybrid analog and digital (A/D) transceiver structure. More specifically, leveraging the channel long-term properties, we design the analog beamformer which aims to minimize the channel estimation error and remain invariant over a long timescale. Then, the beamforming is completed by simple digital signal processing, i.e., maximum ratio combining/maximum ratio transmission (MRC/MRT) or zero forcing (ZF) in the baseband domain. We present analytical bounds on the achievable spectral efficiency taking into account the spatial correlation and imperfect channel state information at the relay station. Our analytical results reveal that the hybrid A/D structure with ZF digital processor exploits spatial correlation and offers a higher spectral efficiency compared to the hybrid A/D structure with MRC/MRT scheme. Our numerical results show that the hybrid A/D beamforming design captures nearly 95% of the spectral efficiency of a fully digital AF relaying topology even by removing half of the RF chains. It is also shown that the hybrid A/D structure is robust to coarse quantization, and even with 2-bit resolution, the system can achieve more than 93% of the spectral efficiency offered by the same hybrid A/D topology with infinite resolution phase shifters.
An Investigation of the Interactions Between Pre-Trained Word Embeddings, Character Models and POS Tags in Dependency Parsing

We provide a comprehensive analysis of the interactions between pre-trained word embeddings, character models and POS tags in a transition-based dependency parser. While previous studies have shown POS information to be less important in the presence of character models, we show that in fact there are complex interactions between all three techniques. In isolation each produces large improvements over a baseline system using randomly initialised word embeddings only, but combining them quickly leads to diminishing returns. We categorise words by frequency, POS tag and language in order to systematically investigate how each of the techniques affects parsing quality. For many word categories, applying any two of the three techniques is almost as good as the full combined system. Character models tend to be more important for low-frequency open-class words, especially in morphologically rich languages, while POS tags can help disambiguate high-frequency function words. We also show that large character embedding sizes help even for languages with small character sets, especially in morphologically rich languages.
ABT-888 restores sensitivity in temozolomide resistant glioma cells and xenografts

Background Temozolomide (TMZ) is active against glioblastomas (GBM) in which the O6-methylguanine-DNA methyltransferase (MGMT) gene is silenced. However, even in responsive cases, its beneficial effect is undermined by the emergence of drug resistance. Here, we tested whether inhibition of poly (ADP-ribose) polymerase-1 and -2 (PARP) enhanced the effectiveness of TMZ. Methods Using patient derived brain tumor initiating cells (BTICs) and orthotopic xenografts as models of newly diagnosed and recurrent high-grade glioma, we assessed the effects of TMZ, ABT-888, and the combination of TMZ and ABT-888 on the viability of BTICs and survival of tumor-bearing mice. We also studied DNA damage repair, checkpoint protein phosphorylation, and DNA replication in mismatch repair (MMR) deficient cells treated with TMZ and TMZ plus ABT-888. Results Cells and xenografts derived from newly diagnosed MGMT methylated high-grade gliomas were sensitive to TMZ while those derived from unmethylated and recurrent gliomas were typically resistant. ABT-888 had no effect on the viability of BTICs or tumor bearing mice, but co-treatment with TMZ restored sensitivity in resistant cells and xenografts from newly diagnosed unmethylated gliomas and recurrent gliomas with MSH6 mutations. In contrast, the addition of ABT-888 to TMZ had little sensitizing effect on cells and xenografts derived from newly diagnosed methylated gliomas. In a model of acquired TMZ resistance mediated by loss of MMR gene MSH6, re-sensitization to TMZ by ABT-888 was accompanied by persistent DNA strand breaks, re-engagement of checkpoint kinase signaling, and interruption of DNA synthesis. Conclusion In laboratory models, the addition of ABT-888 to TMZ overcame resistance to TMZ.
New Insights in Prostate Cancer Development and Tumor Therapy: Modulation of Nuclear Receptors and the Specific Role of Liver X Receptors

Prostate cancer (PCa) incidence has been dramatically increasing these last years in westernized countries. Though localized PCa is usually treated by radical prostatectomy, androgen deprivation therapy is preferred in locally advanced disease in combination with chemotherapy. Unfortunately, PCa goes into a castration-resistant state in the vast majority of the cases, leading to questions about the molecular mechanisms involving the steroids and their respective nuclear receptors in this relapse. Interestingly, liver X receptors (LXRα/NR1H3 and LXRβ/NR1H2) have emerged as new actors in prostate physiology, beyond their historical roles of cholesterol sensors. More importantly LXRs have been proposed to be good pharmacological targets in PCa. This rational has been based on numerous experiments performed in PCa cell lines and genetic animal models pointing out that using selective liver X receptor modulators (SLiMs) could actually be a good complementary therapy in patients with a castration resistant PCa. Hence, this review is focused on the interaction among the androgen receptors (AR/NR3C4), estrogen receptors (ERα/NR3A1 and ERβ/NR3A2), and LXRs in prostate homeostasis and their putative pharmacological modulations in parallel to the patients’ support.
Analysing the potential of seq-to-seq models for incremental interpretation in task-oriented dialogue

We investigate how encoder-decoder models trained on a synthetic dataset of task-oriented dialogues process disfluencies, such as hesitations and self-corrections. We find that, contrary to earlier results, disfluencies have very little impact on the task success of seq-to-seq models with attention. Using visualisations and diagnostic classifiers, we analyse the representations that are incrementally built by the model, and discover that models develop little to no awareness of the structure of disfluencies. However, adding disfluencies to the data appears to help the model create clearer representations overall, as evidenced by the attention patterns the different models exhibit.
Signal, noise and resolution in linear and nonlinear structured‐illumination microscopy

Structured‐illumination microscopy allows widefield fluorescence imaging with resolution beyond the classical diffraction limit. Its linear form extends resolution by a factor of two, and its nonlinear form by an in‐principle infinite factor, the effective resolution in practice being determined by noise. In this paper, we analyse the noise properties and achievable resolution of linear and nonlinear 1D and 2D patterned SIM from a frequency–space perspective. We develop an analytical theory for a general case of linear or nonlinear fluorescent imaging, and verify the analytical calculations with numerical simulation for a special case where nonlinearity is produced by photoswitching of fluorescent labels. We compare the performance of two alternative implementations, using either two‐dimensional (2D) illumination patterns or sequentially rotated one‐dimensional (ID) patterns. We show that 1D patterns are advantageous in the linear case, and that in the nonlinear case 2D patterns provide a slight signal‐to‐noise advantage under idealised conditions, but perform worse than 1D patterns in the presence of nonswitchable fluorescent background.
The impact of rural health insurance and the family physician program on hospitalizations, a beforeafter study at the county level conducted in Tehran province, Iran

Background: The health insurance and family physician reform in Iran were implemented in 2005. This study was conducted to assess the effect of these reforms on avoidable hospitalizations among the rural population of Eslam-shahr County, Iran. Methods: We conducted a before-after study in Eslam-shahr County’s single existing hospital. This county is a part of the Tehran Province of Iran. The demographic characteristics and diagnostic codes of the rural population that were hospitalized during the 2 years leading to, and after the reforms were extracted from the hospital’s electronic information system. A list of 61 three-character and 131 four-character AHs codes were developed based on the literature review. We estimated a logistic regression model which included gender and age as independent variables to assess changes in the probability of avoidable hospitalizations following reform implementation. Analyses were carried out using STATA version 13. Results: We recorded 817 rural hospitalizations before and 967 hospitalizations after reform implementation, suggesting that hospitalization growth after the reforms was almost 18.4%. The logistic regression results show that the probability of avoidable hospitalizations after the interventions had decreased compared to before the interventions were put into place (OR: 0.46; 95% CI: 0.24-0.88). Also, the probability of AHs among the 60< year-old age group was considerably higher compared to other age groups. No statistical relationship was found between avoidable hospitalizations and gender. Conclusion: The reforms may have had a mixed effect on hospitalization. They may result in increased hospitalizations due to responding to the unmet needs of the population, and simultaneously they may lead to a decrease in avoidable hospitalizations and eliminate the costs imposed by them upon the health system.
A Longitudinal Analysis of Chlamydial Infection and Trachomatous Inflammation Following Mass Azithromycin Distribution

ABSTRACT Background: Mass azithromycin distributions are effective for clearing ocular strains of Chlamydia trachomatis, yet infection frequently returns in areas with hyperendemic trachoma. A better understanding of the factors associated with chlamydial reinfection could be helpful to plan trachoma elimination strategies. Methods: This was a prospective cohort study conducted in a trachoma-hyperendemic region of Ethiopia in 2003. As part of a larger cluster-randomized trial, 21 villages were treated with a single mass azithromycin distribution and all children 5 years and younger were monitored for ocular chlamydia and clinically active trachoma at baseline and at 2 and 6 months following the treatment. Results: In 20 villages with available data, azithromycin treatment coverage was 88.7% (95% confidence interval [CI] 85.7–91.8%). In total, 1005 children tested negative for ocular chlamydia at the 2-month visit, of whom 41 became infected by 6 months (1.0 incident chlamydia infections per 100 person-months, 95%CI 0.7–1.4). The presence of intense trachomatous inflammation (TI) at baseline was associated with incident infection at 6 months (incidence rate ratio 1.91, 95%CI 1.03–3.55). Ocular chlamydia infections clustered more within households than communities: (intraclass correlation coefficient 0.01 for communities and 0.29 for households six months posttreatment). Younger children were more likely to have persistent clinically active trachoma (P = 0.03). Conclusions: More intensive antibiotic distributions may be warranted for younger children, for children with TI, and for households containing children with ocular chlamydia infections.