Miracle-dz/UniFAR-FTUs huggingface dataset:
Cancer survivorship: resilience across the lifespan. Proceedings of the National Cancer Institute's and American Cancer Society's 2002 Cancer Survivorship Conference. June 2-4, 2002. Washington, DC, USA.

Received February 28, 2005; accepted May 4, 2005. With contemporary therapy, the majority of children and adolescents who are diagnosed with cancer will be cured. However, curative therapy predisposes individuals to adverse health outcomes that affect the long-term survivor’s quality of life and increase the risk of early mortality. Recognition of the adverse effects of cancer treatment on growth and development, vital organ function, fertility and reproduction, and secondary carcinogenesis has been the stimulus for the development of risk-adapted treatment approaches for pediatric malignancies. Because the consequences of these therapeutic modifications may not manifest for many years, long-term follow-up is required to accurately define new or changing patterns of adverse health outcomes, appropriate screening approaches, and ultimately, risk-reducing interventions. Identification of vulnerable survivors is essential to provide timely interventions to detect, ameliorate, reduce, or prevent cancer-related sequelae. This process is challenging, because risk factors constantly are evolving as cancer therapies are modified and as survivors age. Aging also disrupts the continuity of after-cancer care, as adolescent and young adult survivors graduate from pediatric oncology practices to community medical providers who are largely unfamiliar with cancer-related health risks. Health outcomes research objectives that target cancer survivors must adapt as cancer therapies evolve and as new risk factors for cancer-related morbidity emerge. Prospectively using a multidimensional, comprehensive approach that considers host-related, cancer-related, genetic, and lifestyle factors in combination with results from focused medical and behavioral evaluations obtained from cancer survivors who participate in long-term follow-up programs provides an optimal method of defining high-risk profiles for adverse health outcomes across the age spectrum. Cancer 2005;104(11 Suppl):2638 – 42. © 2005 American Cancer Society.
Semiglobal practical stability of a class of parameterized networked control systems

This paper studies a class of parameterized networked control systems that are designed via an emulation procedure. In the first step, a controller is designed ignoring network so that semiglobal practical stability is achieved for the closed-loop. In the second step, it is shown that if the same controller is emulated and implemented over a large class of networks, then the networked control system is also semiglobally practically asymptotically stable; in this case, the controller parameter needs to be sufficiently small and communication bandwidth sufficiently high.
Somatic Symptom Index (SSI): A New and Abridged Somatization Construct: Prevalence and Epidemiological Correlates in Two Large Community Samples

An abridged somatization construct (the Somatic Symptom Index) derived from the Diagnostic Interview Schedule's somatization disorder items was tested on community epidemiological samples to examine its prevalence, risk factors, and predictive value. The construct had a high prevalence (range, 4.4% to 20% compared with .03% to 0.7% for the full DSM-III somatization disorder diagnosis), was related to low socioeconomic status, female gender, older chronological age, and Hispanic ethnic background. The presence of this construct determined preferential use of medical services and predicted high indices of disability. The Somatic Symptom Index may have practical utility for clinical and community studies of somatoform phenomena.
Spatial distribution of Vespa velutina individuals hunting at domestic honeybee hives: heterogeneity at a local scale

Since its recent introduction into Europe, the yellow‐legged hornet, Vespa velutina, has become a major predator of the domestic honeybee, Apis mellifera, but little is known about its hunting behavior. We studied V. velutina hunting behavior by a capture‐mark‐recapture procedure in an experimental apiary. A total of 360 hornets were captured and tagged, and we determined: (i) the number of hornets visiting the apiary and the changes in time, (ii) the average number of individual visits per half‐day and the time elapsed between consecutive recaptures, and (iii) the individual and global distribution of the hornets in the apiary. More than 50% of the marked hornets were recaptured at least once, this increased to 74% in considering the first marked individuals. We estimated 350 hornets visiting the patch daily with at least 1 visit per half‐day. The number of marked hornets decreased over time while the number of unmarked ones increased, suggesting a turnover of individuals. The reduction of the delay between consecutive visits indicates that hornets became more efficient over time. Most of the hornets (88%) were recaptured in front of different hives but, overall, the global distribution was aggregative. Hornets were mainly recaptured in front of 1 hive which was neither the smallest nor the biggest colony, suggesting that the major cue used by hornets is not the amount of food. We hypothesize that the defensive behavior of the honeybee colony could explain our results which may be promising to further studies.
New Anti-Human Immunodeficiency Virus Type 1 6-Aminoquinolones: Mechanism of Action

ABSTRACT A 6-aminoquinolone derivative, WM5, which bears a methyl substituent at the N-1 position and a 4-(2-pyridyl)-1-piperazine moiety at position 7 of the bicyclic quinolone ring system, was previously shown to exhibit potent activity against replication of human immunodeficiency virus type 1 (HIV-1) in de novo-infected human lymphoblastoid cells (V. Cecchetti et al., J. Med. Chem. 43:3799-3802, 2000). In this report, we further investigated WM5's mechanism of antiviral activity. WM5 inhibited HIV-1 replication in acutely infected cells as well as in chronically infected cells. The 50% inhibitory concentrations were 0.60 ± 0.06 and 0.85 ± 0.05 μM, respectively. When the effects of WM5 on different steps of the virus life cycle were analyzed, the reverse transcriptase activity and the integrase and protease activities were not impaired. By using a transient trans-complementation assay to examine the activity of WM5 on the replicative potential of HIV-1 in a single round of infection, a sustained inhibition of Tat-mediated long terminal repeat (LTR)-driven transcription (>80% of controls) was obtained in the presence of 5 μM WM5. Interestingly, the aminoquinolone was found to efficiently complex TAR RNA, with a dissociation constant in the nanomolar range (19 ± 0.6 nM). These data indicate that WM5 is a promising lead compound for the development of a new class of HIV-1 transcription inhibitors characterized by recognition of viral RNA target(s).
Mycophenolate mofetil therapy in Taiwanese myasthenia gravis.

BACKGROUND Mycophenolate mofetil (MM) has been successfully used for the treatment of immune-mediated diseases, including myasthenia gravis (MG). We compare our experience treating Taiwanese myasthenic patients with MM to analogous Caucasian series. METHODS From October 2003 to April 2008, we treated 6 myasthenic patients with MM for at least one year at Shin Kong Wu Ho-Su Memorial Hospital. The inclusion criteria for MM treatment included poor responses to previous treatment or intolerance to the side effects of previous immunosuppressive therapies. The MM was given orally with a dose of 1 g twice per day. Mandatory surveillance laboratory studies and clinical assessment were performed periodically. RESULTS Three of our six patients responded well to MM treatment in terms of improvement in MG score and achievement of minimal manifestation status. The fourth patient showed delayed onset of response 12 months after commencement of MM treatment. Steroid-sparing effect could be demonstrated in 4 patients. The overall response rate (66%) was slightly lower than that reported for Caucasian series. Clinical improvement generally began in the second to four months. MM was well tolerated. CONCLUSION MM was well tolerated by our six treated patients. Although the clinical response was modest, MM has its advantage of a relatively rapid response onset and steroid-sparing effect.
Defining Genomic Islands and Uropathogen-Specific Genes in Uropathogenic Escherichia coli

ABSTRACT Uropathogenic Escherichia coli (UPEC) strains are responsible for the majority of uncomplicated urinary tract infections, which can present clinically as cystitis or pyelonephritis. UPEC strain CFT073, isolated from the blood of a patient with acute pyelonephritis, was most cytotoxic and most virulent in mice among our strain collection. Based on the genome sequence of CFT073, microarrays were utilized in comparative genomic hybridization (CGH) analysis of a panel of uropathogenic and fecal/commensal E. coli isolates. Genomic DNA from seven UPEC (three pyelonephritis and four cystitis) isolates and three fecal/commensal strains, including K-12 MG1655, was hybridized to the CFT073 microarray. The CFT073 genome contains 5,379 genes; CGH analysis revealed that 2,820 (52.4%) of these genes were common to all 11 E. coli strains, yet only 173 UPEC-specific genes were found by CGH to be present in all UPEC strains but in none of the fecal/commensal strains. When the sequences of three additional sequenced UPEC strains (UTI89, 536, and F11) and a commensal strain (HS) were added to the analysis, 131 genes present in all UPEC strains but in no fecal/commensal strains were identified. Seven previously unrecognized genomic islands (>30 kb) were delineated by CGH in addition to the three known pathogenicity islands. These genomic islands comprise 672 kb of the 5,231-kb (12.8%) genome, demonstrating the importance of horizontal transfer for UPEC and the mosaic structure of the genome. UPEC strains contain a greater number of iron acquisition systems than do fecal/commensal strains, which is reflective of the adaptation to the iron-limiting urinary tract environment. Each strain displayed distinct differences in the number and type of known virulence factors. The large number of hypothetical genes in the CFT073 genome, especially those shown to be UPEC specific, strongly suggests that many urovirulence factors remain uncharacterized.
Secretion of a soluble colonization factor by the TCP type 4 pilus biogenesis pathway in Vibrio cholerae

Colonization of the human small intestine by Vibrio cholerae requires the type 4 toxin co‐regulated pilus (TCP). Genes encoding the structure and biogenesis functions of TCP are organized within an operon located on the Vibrio Pathogenicity Island (VPI). In an effort to elucidate the functions of proteins involved in TCP biogenesis, in frame deletions of all of the genes within the tcp operon coding for putative pilus biogenesis proteins have been constructed and the resulting mutants characterized with respect to the assembly and function of TCP. As a result of this analysis, we have identified the product of one of these genes, tcpF, as a novel secreted colonization factor. Chromosomal deletion of tcpF yields a mutant that retains in vitro phenotypes associated with the assembly of functional TCP yet is severely attenuated for colonization of the infant mouse intestine. Furthermore, we have determined that the mechanism by which TcpF is translocated across the bacterial outer membrane requires the TCP biogenesis machinery and is independent of the type II extracellular protein secretion (EPS) system. These results suggest a dual role for the TCP biogenesis apparatus in V. cholerae pathogenesis and a novel mechanism of intestinal colonization mediated by a soluble factor.
Characterization of NbTiN Thin Films Deposited on Various Substrates

Niobium titanium nitride (NbTiN) thin films were deposited on a selection of different substrates to explore the optimum depositing condition of high-quality NbTiN thin films. The NbTiN films deposited on MgO, Al<sub>2</sub>O<sub>3</sub>, and fused quartz substrates showed excellent superconducting properties with a high <i>T</i><sub>C</sub> of 14.7 K, 14.5 K, 15.2 K, and low resistivity ρ<sub>20 K</sub> of 55 μΩcm, 116 μΩcm, 78 μΩcm, respectively. The chemical composition, crystal structure, and relationship between superconducting properties and crystal structure were systematically investigated by changing the N<sub>2</sub>/(Ar+N<sub>2</sub>) ratio in sputtering gases. The lattice parameter systematically changed as N<sub>2</sub>/(Ar+N<sub>2</sub>) ratio was varied. We found that the superconducting properties depend on the lattice parameter, and the film with the best superconducting properties had a lattice parameter of 4.380 Å (on MgO), 4.345 Å (on Al<sub>2</sub>O<sub>3</sub>), 4.335 Å (on fused quartz).
The Role of the Right Temporoparietal Junction in Social Interaction: How Low-Level Computational Processes Contribute to Meta-Cognition

Accumulating evidence from cognitive neuroscience indicates that the right inferior parietal cortex, at the junction with the posterior temporal cortex, plays a critical role in various aspects of social cognition such as theory of mind and empathy. With a quantitative meta-analysis of 70 functional neuroimaging studies, the authors demonstrate that this area is also engaged in lower-level (bottom-up) computational processes associated with the sense of agency and reorienting attention to salient stimuli. It is argued that this domain-general computational mechanism is crucial for higher level social cognitive processing. NEUROSCIENTIST 13(6): 580—593, 2007. DOI: 10.1177/1073858407304654
A Robust Watermarking Scheme Based on Maximum Wavelet Coefficient Modification and Optimal Threshold Technique

Digital watermarking has received extensive attention as a new method for copyright protection. This paper proposes a robust watermarking algorithm based on maximum wavelet coefficient modification and optimal threshold technique. The medium wavelet coefficients are randomly permutated according to a secret key and divided into subgroups. We modify the maximum wavelet in each subgroup according to the embedded watermark bits, which can effectively resist attacks. During the extraction process, an optimal threshold value calculated by iterative computation is used to extract the watermark from the watermarked image under different attacks, without using the original image or watermark. Numerous experiments are conducted to evaluate the watermarking performance. Experimental results demonstrate the superiority of our scheme on robustness against content-preserving operations and incidental distortions such as JPEG compression, Gaussian noise, median filter, resizing, cropping, and sharpening.
Frequency and Severity of Acute Allergic-Like Reactions to Gadolinium-Containing IV Contrast Media in Children and Adults

OBJECTIVE. The purpose of our study was to determine the frequency and severity of acute allergic-like reactions to IV-administered gadolinium-containing contrast media in children and adults.MATERIALS AND METHODS. Pediatric (younger than 19 years) and adult department of radiology contrast material reaction forms involving patients who experienced acute allergic-like reactions to gadolinium-containing contrast media from January 1, 2001, through December 31, 2006, were retrospectively evaluated for the specific types of acute allergic-like reactions, reaction management, and patient outcomes. Relevant patient medical information, including documentation of prior gadolinium- or iodine-containing contrast material reaction, premedication before acute allergic-like reaction to IV gadolinium-containing contrast material, previous allergic reactions to substances other than contrast media, and history of asthma, was obtained by reviewing electronic medical records.RESULTS. Seventy-eight thousand three hundred.
CONTINUOUS-FIDELITY BAYESIAN OPTIMIZATION

While Bayesian optimization (BO) has achieved great success in optimizing expensive-to-evaluate black-box functions, especially tuning hyperparameters of neural networks, methods such as random search (Li et al., 2016) and multifidelity BO (e.g. Klein et al. (2017)) that exploit cheap approximations, e.g. training on a smaller training data or with fewer iterations, can outperform standard BO approaches that use only full-fidelity observations. In this paper, we propose a novel Bayesian optimization algorithm, the continuous-fidelity knowledge gradient (cfKG) method, that can be used when fidelity is controlled by one or more continuous settings such as training data size and the number of training iterations. cfKG characterizes the value of the information gained by sampling a point at a given fidelity, choosing to sample at the point and fidelity with the largest value per unit cost. Furthermore, cfKG can be generalized, following Wu et al. (2017), to settings where derivatives are available in the optimization process, e.g. large-scale kernel learning, and where more than one point can be evaluated simultaneously. Numerical experiments show that cfKG outperforms state-of-art algorithms when optimizing synthetic functions, tuning convolutional neural networks (CNNs) on CIFAR-10 and SVHN, and in large-scale kernel learning.
Development and psychometric properties of a measure of catheter burden with bladder drainage after pelvic reconstructive surgery

Catheter burden after pelvic reconstructive surgery is an important patient‐reported quality of life outcome in research and clinical practice. However, existing tools focus on long‐term catheter users rather than short‐term postoperative patients. The study aim was to evaluate the psychometric properties of a modified version of the intermittent self‐catheterization questionnaire (ISC‐Q) in postoperative pelvic reconstructive patients.
THE SCHISTOSOMA MANSONI GENE INDEX: GENE DISCOVERY AND BIOLOGY BY RECONSTRUCTION AND ANALYSIS OF EXPRESSED GENE SEQUENCES

Expressed sequence tag (EST) sequencing and analysis is a primary research tool to identify and characterize the Schistosoma mansoni transcriptome. As part of our gene discovery effort, a total of 5,793 ESTs have been generated from clones selected randomly from complementary DNA (cDNA) libraries constructed from male and female adult worms. Assembly analysis of all the 16,813 public S. mansoni ESTs has identified 1,920 distinct tentative consensus sequences (TCs) and 5,571 nonoverlapping ESTs (singletons). Of these, 376 TCs (20%) and 1,449 singletons (26%) are unique to the SUNY/TIGR sequencing effort. Tentative consensus sequences and singletons were distributed into various categories of biological roles associated with cell structure, metabolism, protein fate, signal transduction, transcription, protein synthesis, transporters, and cell growth. The TCs and singletons represent transcripts that can be used as a resource for functional annotation of genomic sequence data, comparative sequence analysis, and cDNA clone selection for microarray projects. The utility of EST analysis is demonstrated by identifying new protease genes, which may be involved in hemoglobin degradation.
Infant feeding patterns in Canterbury.

AIM To examine infant feeding patterns during the first 6 months of life in Canterbury. METHODS A random sample of 10% of all births over a 12 month period in Canterbury was taken from birth notifications (n = 520). Information on the type of feeding was recorded prospectively at three time periods and extracted from available Plunket nursing notes. The participation rate was 81%. Data from nonparticipants on the method of feeding at discharge was obtained from obstetric records. RESULTS Overall, 90.7% were breastfed at discharge. There was no difference between breastfeeding rates of the participants (91%) compared to the nonparticipants. For participants, 88% were exclusively breastfed at discharge which steadily declined to 36% at 24 weeks. However, some breastmilk was still being given to 70% at 24 weeks. CONCLUSION Breastfeeding rates are good in comparison to other nations. However, there is room for improvement particularly maintaining exclusive breastfeeding to at least four months. This could be stimulated by the Baby Friendly Hospital Initiative and the fostering of a baby friendly environment to further support and promote breastfeeding in the community.
Enhancing the proportions of healthy fatty acids in milk from dairy cows

Enhancing the Proportions of Healthy Fatty Acids in Milk from Dairy Cows by Korie A.S. Nelson, Master of Science Utah State University, 2008 Major Professor: Randy Wiedmeier Department: Animal, Dairy, and Veterinary Sciences Twenty cows were used in a repeated measures, block design experiment for 9 wk to determine the effects of feeding partially ruminally inert calcium salts (Ca-salts) of fish oil (FO) and a general fatty acid (FA) supplement (EnerGII) at varying levels. The effects on cow health, milk components, composition of milk FA, and sensory evaluation of milk were evaluated. Cows in the 4 treatments were fed either a control diet of 57% forage and 43% concentrate mix with EnerGII fat supplement at 1.65% of diet DM (CTL) or EnerGII in basal diet was partially replaced with (a) 0.21% partially ruminally inert calcium salts (Ca-salts) of 71% fish oil (Ca-FO71) given at 0.41% DM (FH41); (b) 0.41% inert Ca-FO71 given at 0.83% DM (FH83); or (c) 0.83% inert Ca-FO 43% fish oil (Ca-FO43) given at 0.83% DM (FL). Cow health was not negatively affected by treatment diets. Treatment only significantly affected dry matter intake (DMI) and net energy of lactation (NEL), with FH83 having the lowest DMI. Week of trial significantly affected all milk components except protein percent, which did not change. Dry matter intake, milk yield, fat yield, fat percent, and protein yield demonstrated a net decrease over time. Lactose, solids, and somatic cell count all shared a net increase over time.
Author ' s personal copy Modeling fluid – structure interaction by the particle finite element method in

The OpenSees finite element software framework is extended for simulating fluid–structure interaction (FSI) by the particle finite element method (PFEM). At high levels of the framework, new classes handle meshing and interface detection of the fluid and structure domains and implement the fractional step method in order to solve the governing equations of linear momentum and mass conservation. At lower levels of the framework, new finite element and pressure constraint classes assemble fluid contributions to the global system of equations. Verification and validation examples are presented along with a demonstrative example of wave loading on a coastal structure modeled using geometrically nonlinear frame elements with material nonlinear fiber sections. The extension of OpenSees for FSI allows analysts to simulate the complex phenomena of wave loading on structural models as well as the response of these models to sequential natural hazards such as earthquake induced tsunamis. 2013 Elsevier Ltd. All rights reserved.