Miracle-dz/UniFAR-FTUs huggingface dataset:
Outcome after conservatively managed intracapsular fractures of the femoral neck.

INTRODUCTION In 2012, 2.6% of hip-fracture patients in the UK were treated conservatively. There is little data on outcome for these patients. However, one study demonstrated that though 30-day mortality is higher, mortality over the rest of the year is comparable with that in surgical groups. Therefore, we assessed conservatively managed patients in our unit. METHODS Patients with intracapsular fractures of the femoral neck treated by conservative means between 2010 and 2012 inclusive were identified. Data were collected: American Society of Anaesthesiologists (ASA) grade, Nottingham Hip Fracture Score (NHFS), mobility, mortality (30 days and one year) and pain levels. RESULTS Thirty-two patients formed the study cohort. Mean age was 85.6 years. Median ASA grade was 4. Mortality at 30 days and one year was 31.3% and 56.3%, respectively. There was one case of pneumonia and one of infection. Pressure sores or venous thromboembolism were not documented. Three patients underwent surgery once their health improved. In general, mobility was decreased, but 30.8% of patients could mobilise with two aids or a frame. Only two cases had ongoing problems with pain. CONCLUSIONS Our data are similar to those published previously. Our patients were likely to have higher mortality data due to selection bias. Thirty-day mortality was significantly higher than the national average, but patients surviving 30 days had a prevalence of mortality similar to those managed by surgical means. Despite mobility decreasing from the pre-admission status, a considerable number of patients were free of pain and could mobilise. These data suggest that conservative management of intracapsular fractures of the femoral neck can produce acceptable results.
Platelet-Leukocyte Activation during Hemodialysis Detected with a Monoclonal Antibody to Leukocyte Integrin CD11b

Platelet activation is commonly monitored with a battery of monoclonal antibodies against different platelet epitopes with controversial results. The transient expression of platelet markers and their role mediating interactions with other cells could easily explain these discrepancies. The present study has evaluated whether the analysis of a leukocyte activation antigen (CD11b) could provide more reliable results than detection of platelet activation markers. Cytometric techniques with specific monoclonal antibodies were used to compare the reliability of platelet and leukocyte markers to detect activation. Modifications in the presence of platelet glycoproteins GPIb (CD42b), GPIIIa (CD41) and GPIV (CD36), expression of specific platelet markers (P-selectin (CD62P) and lysosomal protein (CD63)) and leukocyte integrin (CD11b) were assessed during hemodialysis. Platelet antigens remained in uremic patients at levels similar or slightly above those detected in a group of healthy subjects. Modifications of platelet antigens during hemodialysis produced inconclusive results. However, numbers of leukocytes expressing CD11b increased progressively during hemodialysis (17.2 ± 5.1% at 15 min and 21.3 ± 6.6% at 2 h, p < 0.05, vs. baseline 6.9 ± 0.2%). The hemodialysis procedure caused an increased formation of leukocyte-platelet aggregates. Detection of leukocyte CD11b may be a useful marker of overall cellular activation during the hemodialysis procedure.
Telomere shortening in human fibroblasts is not dependent on the size of the telomeric‐3′‐overhang

Telomeres shorten in human somatic cells with each round of DNA replication, and this shortening is thought to ultimately trigger replicative senescence. Telomere shortening is caused partly by the inability of semiconservative DNA replication to copy a linear strand of DNA to its very end. Post‐replicative processing of telomeric ends, producing single‐stranded G‐rich 3′ overhangs, has also been suggested to contribute to telomere shortening. This suggestion implies that a positive correlation should exist between the length of 3′ overhangs and the rate of telomere shortening. We confirmed shortening of overhangs as human lung (MRC5) and foreskin (BJ) fibroblasts approach senescence by measuring overhang length using in‐gel hybridization. However, a large study of fibroblast strains from 21 donors maintained under conditions which lead to two orders of magnitude of variation in telomere shortening rate failed to show any correlation between telomere overhang length and shortening rate, suggesting that overhang length is neither a cause nor a correlate of telomere shortening.
Ameloblasts: Secretory and Resorptive Functions

The sequence of steps which an ameloblast passes through in forming enamel appears remarkably similar in amphibian and man. Despite considerable improvements in understanding the early events in the life cycle that lead to the intracellular synthesis and secretion of enamel matrix by the cell, little is known about the cell's functional role at later stages of the life cycle when the extracellular enamel matrix undergoes classical maturation in becoming fully mineralized.
Genetically engineered Bifidobacterium longum for tumor‐targeting enzyme‐prodrug therapy of autochthonous mammary tumors in rats

A fundamental obstacle in systemic therapy for cancer patients is the specific targeting of therapy directly to solid tumors. A strain of the domestic bacterium Bifidobacterium longum, which is non‐pathogenic and anaerobic, showed selective localization to and proliferation within solid tumors after systemic application. Here, we propose a novel approach to cancer gene therapy in which anaerobic and non‐pathogenic bacteria of the genus B. longum are used to achieve tumor‐specific gene delivery and enzyme‐prodrug therapy. We constructed a plasmid, pBLES100‐S‐eCD, which included eCD. Transfected B. longum produced CD in hypoxic tumors and achieved tumor site‐specific conversion of 5‐FC to 5‐FU. Furthermore, we demonstrated antitumor efficacy in rat bearing autochthonous mammary tumors injected with the transfected B. longum directly or intravenously. This method was confirmed to be effective for enzyme‐prodrug therapy not only by intratumoral injection but also by systemic administration. To estimate the toxicity of this bacterial vector, the systemic immunogenicity was evaluated by ASA reaction and the anaphylactic activity of IgG was evaluated by PCA reaction in guinea pigs. In the ASA reaction, no anaphylaxis symptoms were observed in any immunized guinea pigs injected with transfected B. longum. In the PCA reaction, B. longum/S‐eCD specific‐PCA‐induced antibody was not detected. Thus, we proposed that anaerobic bacteria of the genus B. longum were an attractive and safe tumor‐targeting vector and transfected B. longum was a potential anticancer agent that could effectively and specifically treat solid tumors. (Cancer Sci 2006; 97: 649–657)
The Life Cycle of Family Ownership: International Evidence

We show that in countries with strong investor protection, developed financial markets, and active markets for corporate control, family firms evolve into widely held companies as they age. In countries with weak investor protection, less developed financial markets, and inactive markets for corporate control, family control is very persistent over time. While family control in high investor protection countries is concentrated in industries that have low investment opportunities and low merger and acquisition (M&A) activity, the same is not so in countries that have low investor protection, where the presence of family control in an industry is unrelated to investment opportunities and M&A activity. The Author 2011. Published by Oxford University Press on behalf of The Society for Financial Studies. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com. , Oxford University Press.
The Possibility of Ideological Bias in Structural Macroeconomics Models

An ideologically biased expert faces trade-offs in model design. The perceived model must be autocoherent—its use by all agents delivers a self-confirming equilibrium. Policy may be influenced by manipulating the Keynesian multiplier or the Phillips curve parameters. Ideological bias may arise in a way that resembles well-known historical controversies. A larger reported Keynesian multiplier is favored by more left-wing economists, as is a flatter inflation output trade-off. Some combinations of parameters must be truthfully revealed, illustrating the tight link between parameter identification and the scope for bias that is implied by the autocoherence conditions.
Relationship of Cranial Midline Shift to Outcome of Very‐LowBirth‐Weight Infants with Periventricular Hemorrhagic Infarction

The purpose of this study was to determine the relationship of a cranial midline shift accompanying periventricular hemorrhagic infarction to subsequent handicap in very‐low‐birth‐weight infants. A study group of 44 infants with intraventricular hemorrhage and an associated periventricular hemorrhagic infarction was retrospectively selected from 1,080 very‐low‐birth‐weight infants evaluated by cranial sonography. A cranial midline shift is defined sonographically as displacement of the septum pellucidum (or cavum septi pellucidi) more than 3 mm from the spatial midline. The midline is measured as half the distance between the right and left inner tables on an anterior coronal view. Other sonographic data recorded were the size of the lateral ventricle, the intracranial hemisphere, and the periventricular hemorrhagic infarction. Also noted was the appearance of the area of infarction at the time of initial detection of a midline shift. After discharge, the infants were periodically evaluated for major handicap in vision, hearing, cognition, and motor activity. A midline shift was identified in 29 (66%) of 44 infants with periventricular hemorrhagic infarction. Seven (24%) of the 29 infants with midline shift and 3 (20%) of the 15 infants without a midline shift died. In all of the 22 surviving infants with a midline shift and in 3 (25%) of 12 survivors without a midline shift, a handicap developed (p < 0.01). As a predictor of handicap, midline shift showed a sensitivity of 88% and a specificity of 100%. Predictability was not improved by combining midline shift with the size of the parenchymal infarct. Cranial midline shift associated with periventricular hemorrhagic infarction is a valuable predictor of handicap in very‐low‐birth‐weight infants.
Does Trade Raise Income? Evidence from the Twentieth Century

Efforts to estimate the effects of international trade on a country's real income have been hampered by the failure to account for the endogeneity of trade. Frankel and Romer recently use a country's geographic attributes - notably its distance from potential trading partners - as an instrument to identify the effects of trade on income in 1985. Using data from the pre- World War I, the interwar, and the post-war periods, this paper finds that the Frankel-Romer result is robust to different time periods, i.e., that instrumenting for trade with geographic characteristics raises the estimated positive effect of trade on income by a substantial margin and, in most of our cases, the precision of those estimates. These results suggest that the downward bias of OLS estimates is systematic and may be due to measurement error, a potential source of which is that trade is an imperfect proxy for a host of economically beneficial interactions between countries. However, the results are not robust to the inclusion of another geographic variable, latitude (distance from the equator).
The changing role of employment tribunals: The case of the Employment Appeals Tribunal in Ireland

Employment tribunals were first established to provide a cheap and accessible service for the quick resolution of legally based employment disputes. With the decline of collective industrial relations and the growth of legislation on individual employment rights, employment tribunals have acquired a new prominence. However, in doing so employment tribunals have also been heavily criticized for becoming too legalistic and formal. This article takes issue with this tendency to criticize the work of employment tribunals. It closely investigates the role of the Employment Appeals Tribunal (EAT) in Ireland and finds that while it has become legalistic it still plays an important role in employment standard-setting. The article argues that employment relations systems in Anglo-Saxon countries are increasingly rights-based and that bodies like the EAT now play a key role in the functioning of such systems.
Essays on cooperation and coordination

This thesis examines questions related to game theory, and in particular cooperation and coordination among economic agents. In the first chapter (joint with Noah Myung) we propose a decision making process meant to mimic human behavior. This process is implemented with computational agents. We use these computational agents to run simulations of two coordination games, the minimum-effort coordination game and the Battle of the Sexes game. We find that the computational agents exhibit behavior similar to human subjects from previous experimental work. We then use the computational testbed to develop experimental hypotheses, which are then confirmed in the laboratory using human subjects. In particular, we show that higher cost may actually lead to higher average payoffs in the minimum-effort coordination game. The second chapter examines a model of infinitely repeated games in which agents are boundedly rational. I show that the number of equilibrium outcomes is smaller when agents are boundedly rational. Importantly, cooperative outcomes are still possible in equilibrium, even when players cannot use sophisticated strategies and are not able to perfectly monitor their opponents. The strategy that leads to cooperation is called "Win-Stay, Lose-Shift". Using this strategy, I show that cooperation is possible in equilibrium for a large class of 2x2 games. I also give necessary and sufficient conditions on equilibrium structure for Nx2 games. These conditions suggest that in equilibrium, players must be able to cooperate without getting caught in long periods of conflict. The final chapter focuses on a class of minimum-effort coordination games. I show that the symmetric quantal response equilibrium correspondence takes the shape of an s-shaped curve as long as players are sufficiently rational. Under certain assumptions, this s-shaped correspondence leads to hysteresis. Based on these theoretical results, I develop experiments with the minimum-effort coordination game, and test the hysteresis hypothesis in the laboratory. I find evidence that this hysteresis does occur when human subjects play the minimum-effort coordination game in the lab.
Managing Change, or Changing Managers? The role of middle managers in UK public service reform

Abstract Drawing upon interview data from three case study organizations, we examine the role of middle managers in UK public service reform. Using theory fragments from organizational ecology and role theory, we develop three role archetypes that middle managers might be enacting. We find that rather than wholesale enactment of a ‘change agent’ role, middle managers are balancing three predominant, but often conflicting, change-related roles: as ‘government agent’, ‘diplomat administrator’ and, less convincingly, ‘entrepreneurial leader’. Central government targets are becoming the main preoccupation for middle managers across many public services and they represent a dominant constraint on allowing ‘managers to manage’.
Faculty & Research Working Paper Setting Price or Quantity: Depends on the Seller is Uncertain About

We consider a seller with uncertain demand for its product. If the demand curve were certain, then setting price and setting quantity would be equivalent ways to frame the seller’s problem of choosing a profit-maximizing point on its demand curve. With uncertain demand, these become distinct sales mechanisms. We distinguish between uncertainty about the market size and uncertainty about the consumers’ valuations. Our main results are that (i) for a given marginal cost, an increase in uncertainty about valuation favors setting quantity whereas an increase in uncertainty about market size favos setting price; (ii) keeping demand uncertainty fixed, there is a nonmonotonic relationship between marginal costs and the optimal selling mechanism (setting price or quantity); and (iii) in a bilateral monopoly channel setting, channel coordination occurs except for a conflict zone in which the retailer’s choice of a selling mechanism deviates from the coordinated channel selling mechanism.
Transport resources, mobility and unmet transport needs in old age

ABSTRACT Previous research has shown that mobility and the ability to leave the home are among the essential aspects of older people's quality of life. However, surveys of older people's access to transport resources and the impact of mobility on welfare and wellbeing are few. Many previous studies are based on small samples or qualitative data. The questions addressed in this paper are how transport resources are distributed among different groups of older people, to which degree the transport needs of these groups are met and how this is related to their wellbeing. The empirical analysis is based on a Norwegian nationwide survey among 4,723 respondents 65 years and older. The respondents were asked about their access to transport resources, both private and public, health problems connected to use of transport modes, their daily activities and mobility, their uncovered transport needs and the importance of different activities for their life quality. The analysis reveals great differences between groups; especially between men and women, but also between different age groups and by different place of living. The special transport offered by the local authorities is seen as insufficient, and with increasing age a great deal of older people have low mobility and an uncovered transport need that reduces their life quality.
A Sociological Institutionalist Approach to the Study of Innovation in Governance Capacity

This paper draws on institutionalist approaches as developed in the fields of policy analysis and planning, to develop a methodological approach for assessing how the governance capacity for socially innovative action might emerge. After introducing the problematic of the search for governance relations which have the capacity for social innovation, the second and third parts of the paper summarise the emerging social-constructivist 'institutionalist' approach in policy analysis and planning. The fourth part draws on a three-level analytical model of governance dynamics to explore the dynamics and dialectics of urban governance transformation processes, illustrated with a case study of a socially innovative area-based initiative. The final section considers the power dynamics of episodes of socially innovative governance arising from within civil society and their potential to transform wider governance processes and cultures.
Creativity among R&D professional: Supervisory support and personality traits

Summary The purpose of this study is to examine how supervisory support moderates the relationship between personality and creativity among R&D professional teams. A survey was conducted among 191 participants from 12 departments in the Industrial Technology Research Institute in Taiwan. Results show that supervisory support has various influences on the creativity of professionals with different personality traits. R&D professionals with openness to experience are likely to exhibit creativity only when they perceive high supervisory support. Conscientious professionals are likely to exhibit creativity when supervisors provide less support. Neuroticism was negatively related to creativity only when supervisors provide middle support. This study offers potentially invaluable referral for leaders to stimulate the creativity of subordinates.
Software‐defined network‐based prioritization to avoid video freezes in HTTP adaptive streaming

HTTP adaptive streaming (HAS) is becoming the de facto standard for video streaming services over the Internet. In HAS, each video is segmented and stored in different qualities. Rate adaptation heuristics, deployed at the client, allow the most appropriate quality level to be dynamically requested, based on the current network conditions. It has been shown that state‐of‐the‐art heuristics perform suboptimal when sudden bandwidth drops occur, therefore leading to freezes in the video playout, the main factor influencing users' quality of experience (QoE). This issue is aggravated in case of live events, where the client‐side buffer has to be kept as small as possible in order to reduce the playout delay between the user and the live signal. In this article, we propose a framework capable of increasing the QoE of HAS clients by reducing video freezes. The framework is based on OpenFlow, a widely adopted protocol to implement the software‐defined networking principle. An OpenFlow controller is in charge of introducing prioritized delivery of HAS segments, based on the network conditions and the HAS clients' status. Particularly, the HAS clients' status is obtained without any explicit clients‐to‐controller communication, and thus, no extra signaling is introduced into the network. Moreover, this OpenFlow controller is transparent to the quality decision process of the clients, as it assists the delivery of the segments, but it does not determine the actual quality to be requested. In order to provide a comprehensive analysis of the proposed approach, we investigate the performance of the proposed OpenFlow‐based framework in the presence of realistic Internet cross‐traffic. Particularly, we model two types of applications, namely, HTTP web browsing and progressive download video streaming, which currently represent the majority of Internet traffic together with HAS. By evaluating this novel approach through emulation in several multi‐client scenarios, we show how the proposed approach can reduce freeze time for the HAS clients due to network congestion up to 10 times compared with state‐of‐the‐art heuristics, without impacting the performance of the cross‐traffic applications. Copyright © 2016 John Wiley & Sons, Ltd.
Oil Production in the Lower 48 States: Economic, Geological, and Institutional Determinants

In this paper, we establish an empirical model for oil production in the lower 48 states that represents its economic, physical, and institutional determinants. We estimate a vector error correction model for oil production in the lower 48 states that specifies real oil prices, average production costs, and prorationing by the Texas Railroad Commission. These modifications enable us to generate a model that accounts for most of the variation in oil production in the lower 48 states between 1938 and 1991. The result that oil production in the lower 48 states shares stochastic trends with real oil prices, average production costs, and prorationing indicates that accuracy of Hubbert's bell shaped curve is fortuitous. The importance of these factors also indicates why the basic Hotelling model cannot replicate the production path for oil in the lower 48 states. This inability is critical. The negative economic effects associated with high prices and energy shortages imply that the importance of inconsistencies with the basic Hotelling model identified by this analysis may be sufficient to warrant a greater degree of government intervention in the transition from oil than is currently envisioned by most policy makers.