Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of neurobehavioral impairment in methylmercury‐treated KK‐Ay mice by dynamic weight‐bearing test

Methylmercury (MeHg) is known to cause neurobehavioral impairment in human and experimental animals. We previously reported that MeHg (5 mg Hg/kg) induced severe neurobehavioral dysfunction in 4‐week‐old KK‐Ay mice, although it is difficult to evaluate quantitatively the neurobehavioral impairment in MeHg‐treated KK‐Ay mice because of their obesity. The aim of this study was to evaluate MeHg‐induced neurobehavioral dysfunction in KK‐Ay mice using the dynamic weight‐bearing test, which analyzes the animal's weight distribution between the four limbs. Male 12‐week‐old KK‐Ay mice were treated with MeHg (5 mg Hg/kg) three times per week for 5 weeks. Body weight loss began after approximately 2 weeks of MeHg treatment, and decreased significantly at 4 weeks. Seven of the nine MeHg‐treated mice exhibited overt neurological symptoms such as ataxia and gait disturbance. The weight‐bearing load was lower for the forelimb than for the hindlimb at baseline and until 1 week after MeHg treatment was initiated. In weeks 2‐4, the dynamic weight‐bearing loads on the forelimb and hindlimb were similar. The load on the forelimb exceeded the load on the hindlimb after 5 weeks of treatment. This finding indicates that the dynamic weight‐bearing test is useful for semi‐quantitative evaluation of neurobehavioral impairment in MeHg‐treated rodents, and is less stressful for the animals. Infiltration of CD204‐positive macrophages was observed in the sciatic nerve of MeHg‐treated mice, suggesting that CD204 can serve as a useful marker of tissue injury in peripheral nerves and a possible target in regenerating peripheral nerves and controlling neuropathies.
Ecosystem‐scale methane flux in tropical peat swamp forest in Indonesia

Data on ecosystem‐scale methane (CH4) fluxes in tropical peatlands are currently lacking in the global CH4 budget. Although the waterlogged Indonesian peatlands contain the largest share of peat carbon in South‐East Asia, ecosystem‐scale CH4 budgets have not yet been reported, although these peatlands have the potential to emit CH4. We observed 1‐year variations in the ecosystem‐scale CH4 flux in an undrained secondary peat swamp forest in central Kalimantan, Indonesia, using the eddy covariance method. We found that the peat swamp forest switched from being a CH4 sink during the dry season (as low as −8.9 mg C m−2 day−1) to a source of CH4 during the wet season (up to 10.7 mg C m−2 day−1), and this was dependent on changes in the groundwater level (GWL). The high GWL during the wet season enhanced the anaerobic CH4 production in the surface layer that had more labile organic matter. However, the CH4 emission also increased when the GWL dropped during dry spells in the wet season. The annual CH4 budget in the studied tropical peat swamp forest (0.09–0.17 g C m−2 year−1) was much lower than that in northern, temperate, and subtropical wetlands. We found that CH4 fluxes had almost no effect on the global warming gas budget of the peat swamp forest, and values were only a few percent less than the CO2 fluxes at the same site. In addition, we conducted anaerobic soil incubation experiments to examine the effect of land‐use change on CH4 production. The results indicated much higher CH4 production potential in undrained forest soil than in drained or drained and burned ex‐forest soils. However, although CH4 production decreased in drained soils relative to undrained soils, conserving pristine peat swamp forests with high GWLs is important to suppress global warming because CO2 emissions increase in drained peatlands.
Adverse reactions associated with meningococcal group B vaccine (4CMenB) in adults in special situations.

OBJECTIVE To know the safety profile of the 4CMenB vaccine in adults in special situations. METHOD Security prospective study of phase IV. Inclusion criteria and some vaccination conditions were applied. The adverse reactions described in the data sheet were collected. The adverse reactions evaluation was performed 24 hours after vaccination ("requested") and during the first seven days ("not requested"). RESULTS 72 patients were included (54.2% men, mean age 52.5 years, 81.9% anatomic asplenia). The frequency of fever > 38 ºC in the first 24 hours of vaccination was higher than the observed in the summary of product characteristics for the group of adults (12.5% vs. not known). More than 75% of the patients reported local pain in the first hours [average of the Analog Visual Scale score 3.22 (95% CI: 2.67-3.76) in the first dose and 3.23 (95% CI: 2.69-3.78) in the second dose]. There were no statistically significant differences. 97.22% registered symptoms until 7 days after vaccination. CONCLUSIONS 4CMenB® shows a good safety profile in adults in special situations. The frequency of fever > 38 ºC is higher than expected. Local pain is the most frequently recorded adverse reactions, but the intensity is low. These results suggest a review of the situation in order to suggest a possible modification of the summary of product characteristics of the vaccine.
Extracting Keywords from Open-Ended Business Survey Questions

Open-ended survey data constitute an important basis in research as well as for making business decisions. Collecting and manually analysing free-text survey data is generally more costly than collecting and analysing survey data consisting of answers to multiple-choice questions. Yet free-text data allow for new content to be expressed beyond predefined categories and are a very valuable source of new insights into people's opinions. At the same time, surveys always make ontological assumptions about the nature of the entities that are researched, and this has vital ethical consequences. Human interpretations and opinions can only be properly ascertained in their richness using textual data sources; if these sources are analyzed appropriately, the essential linguistic nature of humans and social entities is safeguarded. Natural Language Processing (NLP) offers possibilities for meeting this ethical business challenge by automating the analysis of natural language and thus allowing for insightful investigations of human judgements. We present a computational pipeline for analysing large amounts of responses to open-ended questions in surveys and extract keywords that appropriately represent people's opinions. This pipeline addresses the need to perform such tasks outside the scope of both commercial software and bespoke analysis, exceeds the performance to state-of-the-art systems, and performs this task in a transparent way that allows for scrutinising and exposing potential biases in the analysis. Following the principle of Open Data Science, our code is open-source and generalizable to other datasets. Comment: 1 figure
Seasonal and meteorological impacts on primary spontaneous pneumothorax.

Background Although several studies have suggested that primary spontaneous pneumothorax (PSP) might occur in clusters, only a few studies have found seasonal variations in PSP occurrence. Some meteorological parameters might be related to the occurrence of PSP occurrence, however, the effects of weather variations on the onset of PSP are still controversial. Methods We examined seasonal differences in the occurrence of PSP and the meteorological risk factors for PSP. All PSP patients aged <40 years who were admitted to Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers from April 2007 through March 2013 were included in the study. Results The incidence rates of PSP were 16.7 and 2.1 per 100,000 person-years in men and women, respectively. The frequency of PSP days among months and seasons was significantly different with a peak in September and autumn. Daily changes in maximum wind speed had positive associations with PSP days [crude OR =1.11 (95% CI: 1.02-1.21) per 1 m/s, P=0.02; multivariable-adjusted OR =1.11 (95% CI: 1.00-1.23) per 1 m/s, P=0.05]. Conclusions PSP tends to cluster seasonally. Increased wind speed may play a role in the development of PSP.
Artificial ventilation during transport: A randomized crossover study of manual resuscitators with comparison to mechanical ventilators in a simulation model

Positive‐pressure ventilation in critically ill patients is commonly administered via a manual resuscitation device or a mechanical ventilator during transport. Our group previously compared delivered ventilation parameters between a self‐inflating resuscitator and a flow‐inflating resuscitator during simulated in‐hospital pediatric transport. However, unequal group access to inline pressure manometry may have biased our results. In this study, we examined the performance of the self‐inflating resuscitator and the flow‐inflating resuscitator, both equipped with inline manometry, and several mechanical ventilators to deliver prescribed ventilation parameters during simulated pediatric transport.
Imitation Learning for Neural Morphological String Transduction

We employ imitation learning to train a neural transition-based string transducer for morphological tasks such as inflection generation and lemmatization. Previous approaches to training this type of model either rely on an external character aligner for the production of gold action sequences, which results in a suboptimal model due to the unwarranted dependence on a single gold action sequence despite spurious ambiguity, or require warm starting with an MLE model. Our approach only requires a simple expert policy, eliminating the need for a character aligner or warm start. It also addresses familiar MLE training biases and leads to strong and state-of-the-art performance on several benchmarks.
Activation vs. Experiential Avoidance as a Transdiagnostic Condition of Emotional Distress: An Empirical Study

Background: From a contextual transdiagnostic approach, this study focuses on the importance of the processes of Experiential Avoidance and Activation in explaining and treating psychological problems. There exists widespread empirical evidence to suggest that the response pattern known as Experiential Avoidance, a general unwillingness to remain in contact with particular private experiences through the use of maladaptive avoidance strategies, acts as a functional dimension in various psychological problems. Activation, that is, maintaining contact with experiences/conditions of life and consequently with associated sources of reward, is a condition present in most therapeutic processes. Although a great deal of research has analyzed the relationship of the value of reward with the etiology and maintenance of psychological problems, Activation, as a transdiagnostic factor, has been studied less. The aim of this paper is to carry out an empirical study of the relationship between Activation, EA and emotional state and analyze the capacity of these two conditions to discriminate the intensity and symptomatology type in subjects with emotional distress. Methods: The Hospital Anxiety and Depression Scale (HADS), Environmental Reward Observation Scale (EROS) and Behavioral Activation for Depression Scale (BADS) were completed by 240 health center users. Results: Of the participants, 55% showed clinically relevant emotional distress. All cases of depression showed clinical anxiety. To discriminate between subjects without (n = 109) and with emotional distress (n = 131), analyses of the ROC curves and logistic regression analysis identified the BADS-Avoidance/Rumination followed by the EROS. To discriminate between subjects with anxiety but without depression (n = 61) and with anxiety and depression (n = 70), the most efficient scales were EROS followed by BADS-Social Impairment. Conclusion: It was shown that people with no emotional complaints maintained greater contact with life experiences and with environmental sources of reward than those with emotional distress. Response patterns showing Experiential Avoidance and a reduction in Activation responses were associated with clinical distress. A reduction in Activation was the condition which distinguished those people with the greatest distress and also the greatest comorbidity of symptoms of depression and anxiety. These data support the transdiagnostic nature of Activation and suggest greater attention should be paid to this concept.
A Novel Automated Endovascular Variable Aortic Control Device to Expand Function of Standard REBOA Catheters

Abstract Background Endovascular methods for hemorrhage control, including Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA), are evolving and are increasingly being applied clinically. Partial flow strategies to mitigate the consequences of complete aortic occlusion have been demonstrated in pre-clinical models to enhance REBOA and expand its application to various shock states. Initial studies demonstrated that controlled partial flow requires precision beyond the capabilities of manual balloon volume adjustment, therefore automation is required. Our group previously developed a proof-of-concept computer-controlled extracorporeal flow circuit capable of precision aortic flow regulation, but it was not clinically applicable. To bring this concept closer to clinical applicability, we have developed the first endovascular strategy to achieve precision aortic flow regulation, termed Endovascular Variable Aortic Control (EVAC). Methods Following instrumentation, 5 Yorkshire-cross swine were subjected to controlled 25% hemorrhage, followed by precision low volume aortic flow regulation using a commercially available compliant balloon catheter pre-positioned in the descending thoracic aorta, connected to a custom, wireless syringe pump. Closed-loop feedback algorithms based on streaming physiologic data were used to determine balloon volume changes. Results The EVAC syringe pump was highly effective at maintaining precise aortic flow throughout the 45-minute intervention period during steady state conditions as well as during rapid fluid administration. Aortic flow and distal mean arterial pressure remained stable during EVAC, despite changing proximal hemodynamics. Balloon volume was dynamic, averaging over 500 changes during intervention, with a mean volume change of 6.7 uL and a maximal change of 100 uL. Conclusion The EVAC syringe pump is capable of achieving aortic flow regulation with high precision, beyond what is achievable with manual control. This serves as a model for future device design, enabling as-of-yet unachievable clinical therapies for hemorrhage and shock states. Future technological development is required to fully translate this into clinical use. Level of Evidence – Level V Study Type – Translational Science Keywords – EVAC, P-REBOA, REBOA, automation, hemorrhage
Flares in Rheumatoid Arthritis Patients with Low Disease Activity: Predictability and Association with Worse Clinical Outcomes

Objective. To investigate predictors of flare in rheumatoid arthritis (RA) patients with low disease activity (LDA) and to evaluate the effect of flare on 12-month clinical outcomes. Methods. Patients with RA who were taking disease-modifying antirheumatic drugs and had a stable 28-joint count Disease Activity Score (DAS28) < 3.2 were eligible for inclusion. At baseline and every 3 months, clinical (DAS28), functional [Health Assessment Questionnaire–Disability Index (HAQ-DI), EQ-5D, Functional Assessment of Chronic Illness Therapy Fatigue scale (FACIT-F), Medical Outcomes Study Short Form-36 (SF-36)], serum biomarkers [multibiomarker disease activity (MBDA) score, calprotectin, CXCL10], and imaging data were collected. Flare was defined as an increase in DAS28 compared with baseline of > 1.2, or > 0.6 if concurrent DAS28 ≥ 3.2. Cox regression analyses were used to identify baseline predictors of flare. Biomarkers were cross-sectionally correlated at time of flare. Linear regressions were performed to compare clinical outcomes after 1 year. Results. Of 152 patients, 46 (30%) experienced a flare. Functional disability at baseline was associated with flare: HAQ-DI had an unadjusted HR 1.82 (95% CI 1.20–2.72) and EQ-5D had HR 0.20 (95% CI 0.07–0.57). In multivariate analyses, only HAQ-DI remained a significant independent predictor of flare (HR 1.76, 95% CI 1.05–2.93). At time of flare, DAS28 and its components significantly correlated with MBDA and calprotectin, but correlation coefficients were low at 0.52 and 0.49, respectively. Two-thirds of flares were not associated with a rise in biomarkers. Patients who flared had significantly worse outcomes at 12 months (HAQ-DI, EQ-5D, FACIT-F, SF-36, and radiographic progression). Conclusion. Flares occur frequently in RA patients with LDA and are associated with worse disease activity, quality of life, and radiographic progression. Higher baseline HAQ-DI was modestly predictive of flare, while biomarker correlation at the time of flare suggests a noninflammatory component in a majority of events.
Unravelling the hip pistol grip/cam deformity: Origins to joint degeneration

This article reviews a body of work performed by the investigators over 9 years that has addressed the significance of cam morphology in the development of hip osteoarthritis (OA). Early hip joint degeneration is a common clinical presentation and preexisting abnormal joint morphology is a risk factor for its development. Interrogating Hill's criteria, we tested whether cam‐type femoroacetabular impingement leads to hip OA. Strength of association was identified between cam morphology, reduced range‐of‐movement, hip pain, and cartilage degeneration. By studying a pediatric population, we were able to characterize the temporality between cam morphology (occurring 1st) and joint degeneration. Using in silico (finite element) and in vivo (imaging biomarkers) studies, we demonstrated the biological plausibility of how a cam deformity can lead to joint degeneration. Furthermore, we were able to show a biological gradient between degree of cam deformity and extent of articular damage. However, not all patients develop joint degeneration and we were able to characterize which factors contribute to this (specificity). Lastly, we were able to show that by removing the cam morphology, one could positively influence the degenerative process (experiment). The findings of this body of work show consistency and coherence with the literature. Furthermore, they illustrate how cam morphology can lead to early joint degeneration analogous to SCFE, dysplasia, and joint mal‐reduction post‐injury. The findings of this study open new avenues on the association between cam morphology and OA including recommendations for the study, screening, follow‐up, and assessment (patient‐specific) of individuals with cam morphology in order to prevent early joint degeneration. Statement of significance: By satisfying Hill's criteria, one can deduct that in some individuals, cam morphology is a cause of OA. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:3125–3135, 2018.
The role of postoperative radiotherapy for radically resected esophageal squamous cell carcinoma: a systemic review and meta-analysis.

Background The role of postoperative radiotherapy (PORT) for radical resected esophageal squamous cell carcinoma (ESCC) remains controversial. This meta-analysis aims to determine whether PORT achieves survival benefit compared with surgery alone (S alone) for radically resected ESCC. Methods The PubMed, EMBASE, Web of Science, and Cochrane Library were searched for relevant articles. The primary endpoints were overall survival (OS) and disease-free survival (DFS), reported as hazard ratios (HR) and 95% confidence intervals (CIs). Results Six randomized trials and 13 retrospective studies that included a total of 8,198 patients were eligible. PORT provided significant OS benefit compared with S alone in retrospective studies (HR =0.75, 95% CI: 0.65-0.85), but not in randomized controlled trials (RCTs) (HR =0.94, 95% CI: 0.81-1.09). PORT was associated with significantly improved DFS and obvious reduction in the risk of locoregional recurrence compared to S alone in either retrospective studies or RCTs. In the subgroup analysis for retrospective studies, PORT gained superior OS in patients with lymph node-positive (pN+), patients with lymph node-negative (pN0) or pT2-3N0, PORT with three-dimensional radiotherapy (3D-RT), PORT with chemotherapy, and patients with R0 resection, respectively. Conclusions The present study shows that PORT can improve DFS and decrease risk of locoregional recurrence in patients with radically resected ESCC, and PORT using 3D-RT or in combination with chemotherapy is likely to be more useful. Further well-designed, prospective studies are needed to confirm the effect of PORT on OS.
“Lost in the sun”—The key role of perceived workplace support for sun‐protective behavior in outdoor workers

BACKGROUND Previous studies show that workplace support for sun-protective behaviors plays an important role in the actual sun-protective behavior of outdoor workers. Therefore, our aim was to examine perceived workplace support (organizational and social support) in relation to different sun-protective behaviors. METHODS A Germany-wide sample of outdoor workers (n = 485) was surveyed via telephone. We analyzed associations of workplace support with sun-protective behaviors, sociodemographic, and occupational characteristics, occupational sun exposure, and concerns about sun. RESULTS A large number of outdoor workers perceived no workplace support for sun protection (eg, 17.8% agreed that sun protection is enforced at their workplace). We found that those who do not get any support are less likely to show sun-protective behaviors. CONCLUSIONS A starting point for a better organizational support is the implementation of mandatory sun protection policies in the workplace. Social support for protection against solar UV exposure can be promoted through safety training and education.
Skin type differences in solar‐simulated radiation‐induced oxidative stress

Human skin protects the body from external damage, pathogens and oxidative stress factors such as ultraviolet (UV) radiation. Excessive exposure to UV radiation can lead to increased production of free radicals and hence to skin damage such as inflammation, premature skin ageing and skin cancer. Besides UV, the visible and near infrared (NIR) regions are also a source of radical production. Half of all free radicals are induced by the visible + NIR region of the solar spectrum in people with skin types I–III, but data on the effects in people with skin types IV–VI are missing.
Reuniting overnutrition and undernutrition, macronutrients, and micronutrients

Over‐nutrition and its late consequences are a dominant theme in medicine today. In addition to the health hazards brought on by over‐nutrition, the medical community has recently accumulated a roster of health benefits with obesity, grouped under “obesity paradox. ” Throughout the world and throughout history until the 20th century, under‐nutrition was a dominant evolutionary force. Under‐nutrition brings with it a mix of benefits and detriments that are opposite to and continuous with those of over‐nutrition. This continuum yields J‐shaped or U‐shaped curves relating body mass index to mortality. The overweight have an elevated risk of dying in middle age of degenerative diseases while the underweight are at increased risk of premature death from infectious conditions. Micronutrient deficiencies, major concerns of nutritional science in the 20th century, are being neglected. This “hidden hunger” is now surprisingly prevalent in all weight groups, even among the overweight. Because micronutrient replacement is safe, inexpensive, and predictably effective, it is now an exceptionally attractive target for therapy across the spectrum of weight and age. Nutrition‐related conditions worthy of special attention from caregivers include excess vitamin A, excess vitamin D, and deficiency of magnesium.