Miracle-dz/UniFAR-FTUs huggingface dataset:
LES FEUX DE CIRCULATION ET LA SECURITE DES PIETONS

LA SECURITE DES PIETONS DANS LA CIRCULATION URBAINE S'EST DETERIOREE DEPUIS BON NOMBRE D'ANNEES. AVEC LA CIRCULATION TOUJOURS CROISSANTE DES VEHICULES, L'INGENIEUR TENTE D'OPTIMISER LES MOUVEMENTS DES VEHICULES; LE PIETON NE S'INSERE QUE DIFFICILEMENT DANS CE SCHEMA D'AMENAGEMENT. DANS LE CALCUL DES FEUX, L'INGENIEUR DOIT TENIR COMPTE DE SA PRESENCE ET CETTE PRISE EN CONSIDERATION AUGMENTE LES INCONVENIENTS SUBIS PAR LES CONDUCTEURS. LE RESULTAT EN EST QUE LES PIETONS, GROUPE MOINS VISIBLE, SONT SOUVENT SERVIS DE MANIERE INADEQUATE. DANS LE PRESENT ARTICLE L'AUTEUR REVOIT LES METHODES DE CALCUL DES FEUX DE CIRCULATION EN CE QUI A TRAIT AUX PIETONS ET EXAMINE LES VARIABLES IMPORTANTES DE CES METHODES DU POINT DE VUE DE LEUR REALISME. L'AUTEUR COMPARE EGALEMENT LES METHODES DE CALCUL UTILISEES DANS DIFFERENTS PAYS ET PROPOSERA DES MESURES DESTINEES A AUGMENTER LA SECURITE DES PIETONS AUX CARREFOURS URBAINS A FEUX. (A).
USE OF DEHYDROISOANDROSTERONE IN PSYCHIATRIC PRACTICE*

Having made a preliminary survey of the effect of dehydroisoandrosterone in selected cases of schizophrenia and schizoid psychopathy we decided to investigate a selected group of 11 patients who, irrespective of age, exhibited constitutional immaturity (especially at the emotional level) and who appeared to be inadequate but not psychotic. The patients had previously received psychiatric treatment of one sort or another, but all psychotherapy was avoided so far as possible during treatment, except in Cases 8 and 9 : interviews were restricted to the recording of subjective and objective findings. Preliminary investigations always included a routine physical examination and urine test, and, where possible, the total 24-hour 1 7-ketosteroid output, together with an evaluation of the alpha and beta factors, was estimated. (In quite a number of cases the total was low, or the beta factor diminished.) Estimations of the white cell count, differential count, weight, and blood pressure were done in some cases before treatment, and repeated at intervals during treatment, together with a repetition of the total 17-ketosteroid estimation. Wherever possible a Rorschach test was carried out before treatment and repeated after a significant period of medication. Organon Laboratories supplied tablets, each containing 10 mg. of epi-dehydroandrosterone, the alternative chemical designation of dehydroisoandrosterone, under the trade name of " diandrone". The cases have been grouped in accordance with their type of response to treatment.
Validation of recall of breast and cervical cancer screening by women in an ethnically diverse population.

BACKGROUND Screening mammogram and Pap smear rates are lower for women in underserved racial and ethnic groups, yet may be overestimated due to reliance on patients' self-reports. The purpose of this study was to determine accuracy of self-reports of mammograms and Pap smears in a multiethnic, multilingual population of African American, Latina, Chinese, Filipina, and White women residing in low-income census tracts of Alameda County, California. METHODS Following a baseline telephone survey of 1,464 women regarding receipt of mammograms and Pap smears, we examined computerized and written medical records to validate the dates and locations of tests reported by women. RESULTS Of 1,464 subjects, 94.9% reported having had a Pap smear, and 87% reported having had a mammogram. For Pap smears, in a subsample of 448 cases, we validated only 69.4% of the women's self-reports, and for mammography, in a subsample of 846 women, we validated only 75.4% of the self-reports. Validation rates differed significantly by ethnicity and site of care for both Pap smears and mammograms. CONCLUSIONS Population estimates of breast and cervical cancer screening rates based upon patient self-reports need to be adjusted downward, by as much as one-quarter to one-third, for low-income, ethnic women.
Practice effects and longitudinal cognitive change in clinically normal older adults differ by Alzheimer imaging biomarker status

Abstract Objective: The objective of this study was to examine practice effects and longitudinal cognitive change in 190 clinically normal elderly classified according to a two-feature biomarker model for Alzheimer’s disease.Methods: All participants completed neuropsychological testing, MRI, FDG-PET, and PiB-PET at their baseline evaluation. We divided participants into four groups based on neuroimaging measures of amyloid (A+ or A−) and neurodegeneration (N+ or N−) and reexamined cognition at 15- and 30-month intervals.Results: The A−N− group showed significant improvements in the memory and global scores. The A+N− group also showed significant improvements in the memory and global scores as well as attention. The A−N+ group showed a significant decline in attention at 30 months. The A+N+ group showed significant improvements in memory and the global score at 15 months followed by a significant decline in the global score at 30 months.Conclusion: Amyloidosis in the absence of neurodegeneration did not have an adverse impact on practice effects or the 30-month cognitive trajectories. In contrast, participants with neurodegeneration (either A−N+ or A+N+) had worse performance at the 30-month follow-up. Our results show that neurodegeneration has a more deleterious effect on cognition than amyloidosis in clinically normal individuals.
A smooth transition protocol for patients with multifocal motor neuropathy going from intravenous to subcutaneous immunoglobulin therapy: an open‐label proof‐of‐concept study

Intravenous immunoglobulin (IVIG) is the first‐line therapy for multifocal motor neuropathy (MMN). This open‐label multi‐centre study (NCT00701662) assessed the efficacy, safety, and convenience of subcutaneous immunoglobulin (SCIG) in patients with MMN over 6 months, as an alternative to IVIG. Eight MMN patients (42–66 years), on stable IVIG dosing, received weekly SCIG at doses equivalent to previous IVIG using a “smooth transition protocol”. Primary efficacy endpoint was the change from baseline to week 24 in muscle strength. Disability, motor function, and health‐related quality of life (HRQL) endpoints were also assessed. One patient deteriorated despite dose increase and was withdrawn. Muscle strength, disability, motor function, and health status were unchanged in all seven study completers who rated home treatment as extremely good. Four experienced 18 adverse events, of which only two were moderate. This study suggests that MMN patients with stable clinical course on regular IVIG can be switched to SCIG at the same monthly dose without deterioration and with a sustained overall improvement in HRQL.
Seizures after Spontaneous Intracerebral Hemorrhage

Objective In patients with spontaneous intracerebral hemorrhage (ICH), the risk factors for seizure and the effect of prophylactic anticonvulsants are not well known. This study aimed to determine the risk factor for seizures and the role for prophylactic anticonvulsants after spontaneous ICH. Methods Between 2005 and 2010, 263 consecutive patients with spontaneous ICH were retrospectively assessed with a mean follow-up of 19.5 months using medical records, updated clinical information and, when necessary, direct patient contact. The seizures were classified as early (within 1 week of ICH) or late (more than 1 week after ICH). The outcomes were measured with the Glasgow Outcome Scale at discharge and the modified Rankin Scale (mRS) at both 2 weeks and discharge. Results Twenty-two patients (8.4%; 9 patients with early seizures and 13 patients with late seizures) developed seizures after spontaneous ICH. Out of 263 patients, prophylactic anticonvulsants were administered in 216 patients. The prophylactic anticonvulsants were not associated with a reduced risk of early (p=0.094) or late seizures (p=0.326). Instead, the factors associated with early seizure were cortical involvement (p<0.001) and younger age (60 years or less) (p=0.046). The risk of late seizure was increased by cortical involvement (p<0.001) and communicating hydrocephalus (p=0.004). The prophylactic anticonvulsants were associated with a worse mRS at 2 weeks (p=0.024) and at last follow-up (p=0.034). Conclusion Cortical involvement may be a factor for provoked seizures. Although the incidence of early seizures tended to decrease in patients prescribed prophylactic anticonvulsants, no statistical difference was found.
Analysis of the presence of FLT 3 gene mutation and association with prognostic factors in adult and pediatric acute leukemia patients

When the FLT3 gene is mutated, it originates a modified receptor with structural changes, which give survival advantage and malignant hematopoietic cell proliferation. Thus, the presence of mutations in this gene is considered an unfavorable prognostic factor. A total of 85 consecutive samples of newly diagnosed untreated patients with AL were included in the study after they provided their informed consent. FLT3 gene mutations were detected by PCR. For the pediatric group, a positive correlation was observed between WBC count and the presence of FLT3-ITD in patients with AML and ALL. Furthermore, children with AML who had the FLT3-ITD mutation showed a tendency to express CD34 in blast cells. In the adult group, the AML patients with FLT3-ITD who expressed CD34 in blast cells had a tendency to worse progression. The present data indicate no association between the prognostic factors evaluated and FLT3 gene mutations in adult with AL. Yet, the presence of FLT3-ITD mutation was significantly related with WBC count in the pediatric group. These findings demonstrate that FLT3 gene mutations can be considered as independent poor prognostic factors.
Fluorescence in situ Hybridization Detection of Cytogenetic Abnormalities in B-cell Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Routine cytogenetic analysis of B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (B-CLL/SLL) frequently fails to identify an abnormal clone due to the low rate of spontaneous mitoses and poor response to mitogen stimulation. Recent studies utilizing interphase fluorescence in situ hybridization (FISH) suggest that prognostically significant chromosomal abnormalities occur more frequently in B-CLL/SLL than has been previously recognized. The purpose of this study was to compare the chromosomal abnormalities detected by karyotyping and FISH in cases of B-CLL/SLL, and to correlate these with clinical features and survival. Seventy-two cases were studied for chromosome 3, 12 or 18 aneuploidy, and for rearrangements involving 11q13, 11q23, 13q14, 14q32 and 17p13. The median age of the patients was 54 years (range, 30-87 years). Clinical staging of B-CLL patients showed that 70% of the patients were Rai stage 0, 1, or 2, and 30% stage 3 or 4. Karyotyping identified chromosomal abnormalities in 31% of the cases, whereas FISH studies were abnormal in 72% of cases including 64% of the cases with normal karyotypes. The most common abnormalities were deletion 13q14 (46%), trisomy 12 (21%), and 14q32 rearrangements (21%). At diagnosis, patients with trisomy 12 were more likely to have a high LDH (P = 0.04), but no other significant differences in the clinical or laboratory features, Rai stage, or survival were found among patients with normal cytogenetics vs. those with chromosomal abnormalities. Univariate analysis showed that B-symptoms (P = 0.044), anemia (P = 0.0006), absolute lymphocytosis > or = 30,000/mm3 (P = 0.029), and Rai stage 3 or 4 (P = 0.0038) at initial presentation were associated with an increased risk of death, but only Rai stage 3 or 4 (P = 0.0038) was significant in multivariate analysis. Interphase FISH studies improve the cytogenetic diagnosis when performed in conjunction with karyotyping in B-CLL/SLL, but the prognostic relevance of various abnormalities could not be confirmed in this study.
Identification of an Insulin-regulated Lysophospholipase with Homology to Neuropathy Target Esterase*

Neuropathy target esterase (NTE) is a member of the family of patatin domain-containing proteins and exhibits phospholipase activity in brain and cultured cells. NTE was originally identified as target enzyme for organophosphorus compounds that cause a delayed paralyzing syndrome with degeneration of nerve axons. Here we show that the structurally related murine protein NTE-related esterase (NRE) is a potent lysophospholipase. The enzyme efficiently hydrolyzes sn-1 esters in lysophosphatidylcholine and lysophosphatidic acid. No lipase activity was observed when triacylglycerols, cholesteryl esters, retinyl esters, phosphatidylcholine, or monoacylglycerol were used as substrates. Although NTE is predominantly expressed in the nervous system, we found the highest NRE mRNA levels in testes, skeletal muscle, cardiac muscle, and adipose tissue. Induction of NRE mRNA concentrations in these tissues during fasting suggested a nutritional regulation of enzyme expression and, in accordance with this observation, insulin reduced NRE mRNA levels in a dose-dependent manner in 3T3-L1 adipocytes. A green fluorescent protein-NRE fusion protein colocalized to the endoplasmic reticulum and lipid droplets. Thus, NRE is a previously unrecognized ER- and lipid droplet-associated lysophospholipase. Regulation of enzyme expression by the nutritional status and insulin suggests a role of NRE in the catabolism of lipid precursors and/or mediators that affect energy metabolism in mammals.
Self‐Neglect and Elder Abuse: Related Phenomena?

LF/(LF + HF) ratio in the rooftop forest (0.50 ± 0.05) was 12% less than that of the control (0.57 ± 0.04). The HF values of the older adults determined in the present study were markedly lower than those of young adults in a previous study, although the LF/(LF + HF) ratios were not different. Numerous studies have demonstrated that LF and HF values for HRV attenuate with older age and that age does not affect the LF/HF ratio.8– 10 The results of the present study were in accordance with those of previous studies on the effect of aging on HRV. Thus, elderly women continued to exhibit autonomic sensitivity to the forest’s natural elements. Although the planted area was limited, the rooftop forest was sufficiently relaxing for elderly patients. In conclusion, elderly women requiring care entered a physiologically relaxed state in a rooftop forest in their healthcare institute. The hospital rooftop forest is an environment where they can experience natural stimulation and be restored, facilitating high-quality geriatric medicine.
The complete mitochondrial genome of scimitar-horned oryx (Oryx dammah)

In this study, a blood sample was obtained from a scimitar-horned oryx in Jinan Paomaling World of Wildlife and the complete nucleotide sequence of scimitar-horned oryx mitochondrial genome was determined. Sequence analysis showed that the genome structure was in accordance with other bovid species that it contained 22 tRNA genes, 12S rRNA gene, 16S rRNA gene, 13 protein-coding genes and 1 control region.
Nondestructive Complex Permittivity Measurement of Conducting Materials Using Open-ended Coaxial Probes

In regard to their physical properties, intrinsically conducting polymers are very good candidates for electronic applications. In this paper, we present the open-ended coaxial method to measure the complex permittivities of Polyaniline/Polyurethane conducting composites at nearly percolation threshold in microwave band. At the microwave frequencies, the permittivities follow the power law (epsiv proportional to f-s) in agreement with the hopping theory. For blends with 1% of Pani, the loss factor (tan delta) had interesting value (tan delta = 3.2 at 1GHz) for use as microwave absorbing materials.
Engineered Hyperphosphorylation of the β2-Adrenoceptor Prolongs Arrestin-3 Binding and Induces Arrestin Internalization

G protein–coupled receptor phosphorylation plays a major role in receptor desensitization and arrestin binding. It is, however, unclear how distinct receptor phosphorylation patterns may influence arrestin binding and subsequent trafficking. Here we engineer phosphorylation sites into the C-terminal tail of the β2-adrenoceptor (β2AR) and demonstrate that this mutant, termed β2ARSSS, showed increased isoprenaline-stimulated phosphorylation and differences in arrestin-3 affinity and trafficking. By measuring arrestin-3 recruitment and the stability of arrestin-3 receptor complexes in real time using fluorescence resonance energy transfer and fluorescence recovery after photobleaching, we demonstrate that arrestin-3 dissociated quickly and almost completely from the β2AR, whereas the interaction with β2ARSSS was 2- to 4-fold prolonged. In contrast, arrestin-3 interaction with a β2-adrenoceptor fused to the carboxyl-terminal tail of the vasopressin type 2 receptor was nearly irreversible. Further analysis of arrestin-3 localization revealed that by engineering phosphorylation sites into the β2-adrenoceptor the receptor showed prolonged interaction with arrestin-3 and colocalization with arrestin in endosomes after internalization. This is in contrast to the wild-type receptor that interacts transiently with arrestin-3 at the plasma membrane. Furthermore, β2ARSSS internalized more efficiently than the wild-type receptor, whereas recycling was very similar for both receptors. Thus, we show how the interaction between arrestins and receptors can be increased with minimal receptor modification and that relatively modest increases in receptor-arrestin affinity are sufficient to alter arrestin trafficking.
From Symmetric Nets to Differential Equations exploiting Model Symmetries

Stochastic Symmetric Nets (SSN) are a High-Level Stochastic Petri Net formalism which provides a parametric system description and an efficient analysis technique that exploit system symmetries to automatically aggregate its states. Even if significant reductions can be achieved in highly symmetric models, the reduced state space can still be too large to derive and/or solve the underlying stochastic process, so that Monte Carlo simulation and fluid approximation remain the only viable ways that need to be explored. In this paper, we contribute to this line of research by proposing a new approach based on fluid approximation to automatically derive from an SSN model a set of Ordinary Differential Equations (ODEs) which mimic the system behavior, and by showing how the SSN formalism allows to define an efficient translation method which reduces the size of the corresponding ODE system with an automatic exploitation of system symmetries. Additionally, some case studies are presented to show the effectiveness of the method and the relevance of its application in practical cases.
Studies on M . 1 ( » pn / clI 111 rill lit and M . lepro ( ! in Tissue Culture

Despite many attempts over the years, neither the rat leprosy bacillus (M. lepraemHr'ium) nor the human leprosy bacillus ( M. leprae) has been grown in ordinary bacteriologic media. I n v ivo, the organisms are obligate intracellular parasites; to thrive in vitTO, like viruses, they may require an intracellular environment. Tissue culture, therefore, seemed an obvious approach to the problem. To begin our studies of M. lepraemu1'ium in ti ssue culture we used monocytes, because, in the natural host, the bacilli have a predilection for cells of the reticulo-endothelial system. In 1956 and 1957 monocytes were kept in good condition for 80 days in a medium of embryo extract, and Balanced Salt Solution (BSS ), or Parker's 199 in which albumin and globulin were substituted for the usual serum component. This medium required renewal only every 10 days. However, unlike Chang (1), we did not obtain multiplication of M. Zepraemmium when using quantitative methods of assessment. Spleen explants from mice infected in v ivo were also tried, and, although assessment of these cultures was difficult, doubling numbers were observed (9) . Because the life of the explan ts was limited, and because explants, like monocytes, could not be transferred , neither appeared to be a suitable host cell for continuous multiplication of M. Zepraemtt1'ium in vitTO. We turned our attention therefore to some of the established cell lines. The first cell line used was L strain , a mouse fibroblast which is phagocytic and ingests M. lepraemllrium very well. In 17
In Vitro Activities of Six Quinolones and Mechanisms of Resistance in Staphylococcus aureus and Coagulase-Negative Staphylococci

ABSTRACT Of 94 clinical isolates of Staphylococcus aureus(n = 51) and coagulase-negative staphylococci (CNS) (n = 43), mutations in the quinolone resistance-determining region of topoisomerases GrlA, GrlB, GyrA, and GyrB together with MICs of six quinolones were analyzed. Amino acid substitutions at identical residues (GrlA residues 80 and 84; GyrA residues 84 and 88) were found in S. aureus and CNS. Active efflux, as suggested by blocking by reserpine, contributed substantially to the resistance phenotype in some strains. Among ciprofloxacin, clinafloxacin, levofloxacin, nalidixic acid, trovafloxacin, and sparfloxacin, a 0.5-μg/ml concentration of sparfloxacin discriminated best between strains with two or three mutations and those with no mutations.
A cross-sectional study of helminths in rural scavenging poultry in Tanzania in relation to season and climate

Abstract A cross-sectional study on the prevalence of helminths in rural scavenging poultry on six hundred adult chickens selected randomly from six villages in the Morogoro Region, Tanzania during the wet and the dry seasons, was conducted. The trachea and gastrointestinal tract of each bird were examined for the presence of parasites. All chickens were infected with one or several species of helminths, the average being 4.8 ±1.7 helminths per chicken during the wet season and 5.1 ± 1.8 during the dry season. A total of 29 different helminth species were shown in the trachea or the gastrointestinal tract. The following species were identified: Syngamus trachea (0.7% (wet season), 2% (dry season)); Gongylonema ingluvicola (6.3%, 17.7%); Tetrameres americana (54.3%, 60.3%); Dispharynx nasuta (0%, 2.7%); Acuaria hamulosa (8.3%, 19.3%); Ascaridia galli (28.3%, 32.3%); Heterakis gallinarum (74.0%, 78.7%); H. isolonche (18.7%, 5.0%); H. dispar (25.7%, 6.3%); Allodapa suctoria (40.0%, 52.0%); Subulura strongylina (3.3%, 1.0%); Strongyloides avium (0.3%, 3.0%); Capillaria annulata (2.0%, 0.0%); C. contorta (9.0%, 1.0%); C. caudinflata (2.0%, 4.3%); C. obsignata (8.7%, 25.0%); C. anatis (4.0%, 9.0%); C. bursata (1.0%, 2.7%); Raillietina echinobothrida (41.3%, 46.3%); R. tetragona (25.3%, 21.3%); R. cesticillus (8.7%, 2.7%); Choanotaenia infundibulum (0.0%, 3.7%); Hymenolepis carioca (9.0%, 18.0%); H. cantaniana (48.0%, 43.0%); Amoebotaenia cuneata (39.3%, 36.0%); Metroliasthes lucida (1.0%, 0.3%); Davainea proglottina (5.7%, 0.3%) and Polymorphus boschadis (0.3%, 0.0%). No trematodes were found. No correlation was found between season and prevalence, or season and mean worm burdens. Twelve helminths of the species recovered represent new local records.