Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevention of haemarthrosis in a murine model of acute joint bleeding

Summary. Preservation of normal joint function in patients with haemophilia is a goal of modern therapy. Regular injections of anti‐haemophilic factor concentrate reduce the risk of joint bleeding, the optimal regimen for which remains under investigation. The goals of the experiment described here are: (i) to assess the capacity of a murine model of severe haemophilic arthropathy to predict the likelihood of success of a test product to prevent joint bleeding and the complications that follow and (ii) to compare the effectiveness of recombinant human activated factor VII (rFVIIa) to recombinant human factor VIII (rFVIII) to prevent acute joint bleeding in the mouse model of haemarthrosis. Mice lacking expression of FVIII received a single intravenous injection of human rFVIII (280 U kg−1), rFVIIa (10 mg kg−1) or vehicle prior to blunt trauma injury to the knee joint. Mice receiving rFVIII and rFVIIa developed less injury‐induced joint bleeding, swelling and loss of range of motion compared to mice pretreated with vehicle. Despite the reduction in clinical symptoms, synovial hyperplasia was evident in all groups after 7 days although less pronounced in mice receiving rFVIII and rFVIIa. The data under these experimental conditions demonstrate: (i) that this model can be used to evaluate novel therapies designed to prevent joint bleeding (prophylaxis) and (ii) both rFVIII and rFVIIa reduced acute haemarthrosis but did not completely prevent synovitis, the sequelae of blood induced joint injury.
The Dolphin Sonar: Excellent Capabilities In Spite of Some Mediocre Properties

Dolphin sonar research has been conducted for several decades and much has been learned about the capabilities of echolocating dolphins to detect, discriminate and recognize underwater targets. The results of these research projects suggest that dolphins possess the most sophisticated of all sonar for short ranges and shallow water where reverberation and clutter echoes are high. The critical feature of the dolphin sonar is the capability of discriminating and recognizing complex targets in a highly reverberant and noisy environment. The dolphin’s detection threshold in reverberation occurs at a echo‐to reverberation ratio of approximately 4 dB. Echolocating dolphins also have the capability to make fine discriminate of target properties such as wall thickness difference of water‐filled cylinders and material differences in metallic plates. The high‐resolution property of the animal’s echolocation signals and the high dynamic range of its auditory system are important factors in their outstanding discrimination capabilities. In the wall thickness discrimination of cylinder experiment, time differences between echo highlights at small as 500–600 ns can be resolved by echolocating dolphins. Measurements of the targets used in the metallic plate composition experiment suggest that dolphins attended to echo components that were 20–30 dB below the maximum level for a specific target. It is interesting to realize that some of the properties of the dolphin sonar system are fairly mediocre, yet the total performance of the system is often outstanding. When compared to some technological sonar, the energy content of the dolphin sonar signal is not very high, the transmission and receiving beamwidths are fairly large, and the auditory filters are not very narrow. Yet the dolphin sonar has demonstrated excellent capabilities in spite the mediocre features of its “hardware. ” Reasons why dolphins can perform complex sonar task will be discussed in light of the “equipment” they possess.
Powerful goodness‐of‐fit tests based on the likelihood ratio

Summary. A new approach of parameterization is proposed to construct a general goodness‐of‐fit test. It can not only generate traditional tests (including the Kolmogorov–Smirnov, Cramér–von Mises and Anderson–Darling tests) but also produce new types of omnibus tests, which are generally much more powerful than the old ones.
Learning to Generate Rock Descriptions from Multivariate Well Logs with Hierarchical Attention

In the shale oil & gas industry, operators are looking toward big data analytics to optimize operations and reduce cost. In this paper, we mainly focus on how to assist operators in understanding the subsurface formation, thereby helping them make optimal decisions. A large number of geology reports and well logs describing the sub-surface have been accumulated over years. Issuing geology reports is more time consuming and depends more on the expertise of engineers than acquiring the well logs. To assist in issuing geology reports, we propose an encoder-decoder-based model to automatically generate rock descriptions in human-readable format from multivariate well logs. Due to the different formats of data, this task differs dramatically from image and video captioning. The challenges are how to model structured rock descriptions and leverage the information in multivariate well logs. To achieve this, we design a hierarchical structure and two forms of attention for the decoder. Extensive validations are conducted on public well data of North Dakota in the United States. We show that our model is effective in generating rock descriptions. The two forms of attention enable the provision of a better insight into relations between well-log types and rock properties with our model from a data-driven perspective.
Preferences for partner notification method: variation in responses between respondents as index patients and contacts

There have been very few studies focusing on what form of communication patients would find acceptable from a clinic. This study looks at the differences in preferences for various partner notification methods when the respondents were index patients compared with when they had to be contacted because a partner had a sexually transmitted infection (STI). There were 2544 respondents. When the clinic had to notify partners, respondents were more likely to report the method as good when a partner had an STI and they were being contacted compared with when the respondents had an infection and the partner was being contacted. The opposite was true for patient referral partner notification. Therefore, there are variations in the preferences of respondents for partner notification method, which depend on whether they see themselves as index patients or contacts.
The Adoption of Ergonomic Innovations for Injury Prevention : Examples from the building construction and health care industries

Studies of how people relate to the risk of occupational injury indicate that there is a tendency to underestimate the risk at work compared to other risks in society. Ultrasound examinations of the heart involve a static and very uncomfortable working posture for the sonographer. As a result many sonographers experience shoulder and neck pains which can result in long term sickness leaves.The purpose of the study was to evaluate how a more radical ergonomic innovation, a remote controlled ultrasound robot for cardiac examinations, Medirob, has been adopted. The study was conducted by interviews with department heads and heads of clinics, responsible for the procurement of the equipment.The results of this study have shown that it is not maybe enough to solve an ergonomic problem with an innovation to get it accepted and used. To prevent injuries the intervention must also have other qualities, for example improved productivity.
ANALISA PENGARUH FAKTOR-FAKTOR FRAUD TRIANGLE TERHADAP KECURANGAN LAPORAN KEUANGAN PADA PERUSAHAAN PROPERTY DAN REAL ESTATE YANG TERDAFTAR DI BURSA EFEK INDONESIA

This study aims to detecting financial statement fraud, based on the analysis of the fraud triangle adoption in SAS No.99. The variables of the fraud triangle that is used is a proxy financial stability with ACHANGE, external pressure that proxy by leverage, personal financial need proxy by OSHIP, financial target proxy by ROA, nature of industry proxy by receivable, ineffective monitoring proxy by BDOUT and rasionalization by TACC proxy. In this study financial statement fraud uses a proxy earnings management with discretionary accruals as the dependent variable. The population of this study is the property and real estate companies listed in Indonesia Stock Exchange in 2010 and 2011. The sample selection is done by using purposive sampling method and total sample of this study is 39 companies. Data analysis was performed with the classical assumption and hypothesis testing using linear regression. The results of this study indicate that the financial stability (ACHANGE) and Rationalization (TACC) have influence to the financial statement fraud. Meanwhile, LEV, OSHIP, ROA, RECEIVABLE and BDOUT have no significant impact on financial statement fraud.
Heterogeneity of nonimmune immunoglobulin Fc reactivity among gram-positive cocci: description of three major types of receptors for human immunoglobulin G

Two hundred and thirty strains of various gram-positive cocci were tested for quantitative, nonimmune binding of radiolabeled human polyclonal immunoglobulin G (IgG). The majority of coagulase-positive staphylococci and streptococci belonging to serogroups C and G showed a high uptake of IgG. The binding of immunoglobulin to group A streptococci was considerably less, with a number of strains completely negative. None of the pneumococcal or the group B or D streptococcal strains displayed any binding capacity. Heterogeneity of the IgG reactivity of various reactive strains was studied in an inhibition assay using 10 different animal serum pools. Three different inhibition patterns were seen, each of them revealing a striking degree of homogeneity within single bacterial species. Staphylococcus aureus and group A streptococci, respectively, constituted two homogeneous groups which differed markedly from each other and from C and G streptococci. No differences were observed between group C and G streptococci. Based on the profound differences between these homogeneous groups, three major types of Fc receptors could be defined. Type I and II Fc receptors were found on S. aureus and on group A streptococci, respectively. Fc receptor type III represented the immunoglobulin-binding structure of both group C and G streptococci.
Measuring empathy in healthcare profession students using the Jefferson Scale of Physician Empathy: Health provider – student version

While empathy is commonly accepted as a mutually beneficial aspect of the health provider–patient relationship, evidence exists that many health profession students are unable to demonstrate this important skill. This study, the initial phase of a 2-year longitudinal series, examined measurement properties of the Jefferson Scale of Physician Empathy (JSPE) adapted for administration to health profession students (JSE-HPS version), and investigated group differences of empathy scores in the baccalaureate nursing (BSN) program within the College of Health Professions at a public university in the southeastern part of the USA. The 20-item survey and a demographic questionnaire were completed by 265 BSN students. Correlational analyses, t-test, and analysis of variance were used to examine internal relationships and group differences. Results showed the median item-total score correlation was statistically significant (0.42). The internal consistency of the scale (Cronbach’s coefficient α) was 0.78, falling within the generally agreed standard. Test-retest reliability coefficients were acceptable at 0.58 (within 3 months interval) and 0.69 (within 6 months interval) between testing. Women scored higher than men and older students outscored younger classmates. No significant relationship was found between empathy scores and ethnicity, previous non-nursing degree, or importance of religion to the participant. These findings support measurement properties of the JSE-HPS version, and can bolster the confidence of researchers in using the Scale for measuring empathy in diverse health profession students, as one component of program evaluation as well as evaluating interprofessional learning activities among diverse healthcare professional students and interprofessional collaboration.
Decoder-based multi-context interconnect architecture

Multi-context FPGAs are a convenient solution for run-time reconfiguration, but they suffer from large area occupation. This is mainly due to programmable interconnect configuration memories which need to be replicated as many times as the number of contexts. To overcome this limitation a new decoder-based interconnect architecture is proposed. Dramatic improvements in terms of area and delay with respect to previous approaches are presented, such that multi-context FPGAs can finally become a viable solution for next generation configurable devices.
miR-146a Induces Differentiation of Periodontal Ligament Cells

Differentiation of periodontal ligament (PDL) cells occurs under specific induction; furthermore, NF-κB signaling is important for regulation of bone differentiation. MicroRNAs are small non-coding RNAs that repress the translation of target genes and modulate cellular processes. miR-146a has been reported to modulate NF-κB signaling. This study hypothesized that miR-146a has a regulatory role in PDL differentiation by affecting NF-κB signaling. Immortalized PDL (I-PDL) cell lines were established by exogenous telomerase expression. The genesis of alkaline phosphatase and the up-regulation of miR-146a were induced by ascorbic acid in the I-PDL cells and primary PDL cells. I-PDL cells with exogenous miR-146a expression showed attenuation of NF-κB activity and exhibited higher differentiation relative to the controls. Exogenous NF-κB expression decreased the expression of differentiation markers, while the inactivation of endogenous NF-κB increased alkaline phosphatase in I-PDL cells. This study concludes that miR-146a promotes the differentiation in PDL cells through the down-regulation of NF-κB signaling.
Neuropeptide Y stimulates hypertrophy of adult ventricular cardiomyocytes.

It was investigated whether neuropeptide Y (NPY) could exert a trophic effect on ventricular myocytes isolated from the adult rat heart. Two different culture models were used: day 1 and 7 cultures of cardiomyocytes. In day 1 and 7 cultures, NPY caused an increase in cellular protein mass. In day 1 cultures, NPY (10 nM) increased the protein-to-DNA ratio within 24 h by 10.1 +/- 2.8% (P < 0.01), but did not stimulate the incorporation of [14C]phenylalanine into cell proteins. The degradation of proteins was retarded in presence of NPY, revealed by pulse-chase experiments. In day 7 cultures, NPY (10 nM) increased the protein-to-DNA ratio within 24 h by 33.9 +/- 5.0% (P < 0.01), increased the RNA-to-DNA ratio by 19.2 +/- 6.4%, and stimulated the incorporation of [14C]phenylalanine by 45.5 +/- 4.5% (P < 0.01). As in day 1 cultures, protein degradation was retarded. The specific activities of cytosolic creatine kinase and lactate dehydrogenase were increased in presence of NPY. This study demonstrates for the first time that NPY is a trophic factor for cardiomyocytes. NPY can cause an increase in cellular mass of protein, i.e., hypertrophy, by two mechanisms: 1) reduction of degradation of protein, found in day 1 and 7 cultures, and 2) stimulation of protein synthesis, observed only in day 7 cultures. The responsiveness of protein synthesis to NPY stimulation is induced during prolonged incubation in culture.
Modeling Structural Adaptation of Microcirculation

The functional properties of microcirculation crucially depend on its angioarchitecture, (i.e., vessel arrangement and morphology). The microcirculation is subject to continuous dynamic structural adaptation (i.e., remodeling) controlled by hemodynamic and metabolic stimuli. Due to the complexity of the interactions among stimuli, reactions, and functional properties, an adequate understanding of structural adaptation requires mathematical models in addition to experimental investigations. Mathematical models have been developed that allow the prediction of realistic vascular properties, based on generic patterns of vascular responses. These models can be used to investigate and predict distributions of vessel morphology consistent with certain putative adaptation principles of terminal vascular beds in response to local hemodynamic and metabolic conditions. They have suggested new hypotheses, including the importance of conducted responses in network adaptation, and can explain the mechanisms underlying observed structural and functional network properties. In the future, the value of such models can be enhanced by including the effects of longitudinal stretch and pulsatility, the relationship between acute tone and structural adaptation, and the description of molecular and cellular mechanisms underlying structural responses of microvessels.
A widely expressed transcription factor with multiple DNA sequence specificity, CTCF, is localized at chromosome segment 16q22.1 within one of the smallest regions of overlap for common deletions in breast and prostate cancers

The cellular protooncogene MYC encodes a nuclear transcription factor that is involved in regulating important cellular functions, including cell cycle progression, differentiation, and apoptosis. Dysregulated MYC expression appears critical to the development of various types of malignancies, and thus factors involved in regulating MYC expression may also play a key role in the pathogenesis of certain cancers. We have cloned one such MYC regulatory factor, termed CTCF, which is a highly evolutionarily conserved‐11‐zinc finger transcriptional factor possessing multiple DNA sequence specificity. CTCF binds to a number of important regulatory regions within the 5′ noncoding sequence of the human MYC oncogene, and it can regulate its transcription in several experimental systems. CTCF mRNA is expressed in cells of multiple different lineages. Enforced ectopic expression of CTCF inhibits cell growth in culture. Southern blot analyses and fluorescence in situ hybridization (FISH) with normal human metaphase chromosomes showed that the human CTCF is a single‐copy gene situated at chromosome locus 16q22. Cytogenetic studies have pointed out that chromosome abnormalities (deletions) at this locus frequently occur in many different human malignancies, suggesting the presence of one or more tumor suppressor genes in the region. To narrow down their localization, several loss of heterozygosity (LOH) studies of chromosome arm 16q in sporadic breast and prostate cancers have been carried out to define the most recurrent and smallest region(s) of overlap (SRO) for commonly deleted chromosome arm 16q material. For CTCF to be considered as a candidate tumor suppressor gene associated with tumorigenesis, it should localize within one of the SROs at 16q. Fine‐mapping of CTCF has enabled us to assign the CTCF gene to about a 2 centiMorgan (cM) interval of 16q22.1 between the somatic cell hybrid breakpoints CY130(D) and CY4, which is between markers D16S186 (16AC16‐101) and D16S496 (AFM214zg5). This relatively small region, containing the CTCF gene, overlaps the most frequently observed SROs for common chromosomal deletions found in sporadic breast and prostate tumors. In one of four analyzed paired DNA samples from primary breast cancer patients, we have detected a tumor‐specific rearrangement of CTCF exons encoding the 11‐zinc‐finger domain. Therefore, taken together with other CTCF properties, localization of CTCF to a narrow cancer‐associated chromosome region suggests that CTCF is a novel candidate tumor suppressor gene at 16q22.1. Genes Chromosomes Cancer 22:26–36, 1998. © 1998 Wiley‐Liss, Inc.
Effects of a Facilitated Fee Waiver Program on Participation in Youth Sports Programs

Registration fees can be an economic barrier to participation in public youth sports programs. While some programs offer to waive the registration fee, many do not, and those that do require that parents provide income documentation during the registration process in order to obtain the waiver. This requirement may discourage waiver applications that, in turn, may reduce participation by low-income children. This article describes the results of a demonstration program that allowed parents to obtain a youth sports programs registration fee waiver through a simple request, without demonstrating need. The demonstration found that a “facilitated waiver program” had a dramatic effect on waiver applications; a twelvefold increase was observed. Waiver applications increased the most among children attending schools in low-income neighborhoods. Those who requested waivers had strong attendance records at games and practices in the programs, and parental support was also high. Despite the benefits of facilitated waivers, however, their use alone is not sufficient to overcome the range of economic barriers to participation in youth sports programs.
An Analysis of Factors Affecting the Capital Structure and Return on Shares with Family Ownership as a Moderating Variable (An Empirical Study of Companies that are Listed in the Indonesia Stock Exchange)

In doing daily activities of the Company, funding is required to achieve the goals set. This fund may be obtained from internal and external sources. Funds from the internal form of retained earnings and own capital, funds from the external form of a loan from a third party that are both long term and short term, both investment loans and working capital loans. The composition of the debt to equity describes the financial structure, and the composition of long-term debt to equity capital structure illustrates. Financial management seeks to optimize the management of these resources. Capital structure and stock returns are important parts of the analysis of a company’s financial statements. There has been a lot of research conducted on these two components above. But no theory cannot explain which ideal factors that have affect the optimal capital structure and stock return. Therefore, the main objective of this research is to analyze factors affecting the capital structure and return on share. The independent variable in this research are growth, profitability, risk, dividend yield, while family ownership is a moderating variable. Company size is a control variable. The research is focused on companies listed on Indonesian Stock Exchange for period of 2010- 2012. The data was collected using purposive sampling method. The sample used that meet the qualifications are 378 samples. The statistical method used is multiple regressio using SPSS as a tool. The classic assumption tests – normality test, multicolinearity test, heteroscedacity test, autocolinearity test, test of coefficient determination and F-test were done before testing the hypothesis. The results of the study showed that of the four variables proposed in this research proved the hypothesis which the growth of assets, profitability (ROE), risk and dividend yield, only growth have a positive effect on the capital structure, while profitability and dividend yield variable has a negative effect, while the risk is has not an influence on the capital structure. While on stock returns, only profitability (ROE) have a positive influence, growth, profitability and risk have no effect on stock returns. In this study also shawing from that family ownership as a moderating variable, family ownership only weakened the relation between profitability and capital structure. For the other variables, family ownership did not moderate the relation between each variable and the capital structure as well as stock returns.