Miracle-dz/UniFAR-FTUs huggingface dataset:
Auditory P300 in Noise in Younger and Older Adults

Abstract Background: Older adults often report difficulty hearing in background noise which is not completely attributable to peripheral hearing loss. Although age-related declines in cognition and hearing in background noise occur, the underlying age-related changes in processing of auditory stimuli in background noise has yet to be fully understood. The auditory P300 has the potential to elucidate the effects of age on auditory and cognitive processing of stimuli in background noise, but additional research is warranted. Purpose: The purpose of this study was to investigate age-related differences in cognitive processing of auditory stimuli by evoking the auditory P300 at multiple signal-to-noise ratios (SNRs). Research Design: A two-group, repeated measures study design was used. Study Sample: A convenience sample of 35 participants, 15 older adults (mean age of 66.4 yr) and 20 younger adults (mean age of 21.1 yr), participated in the study. All participants had negative otologic and neurological histories. Data Collection and Analysis: The auditory P300 was evoked using an oddball paradigm with 500 (frequent) and 1000 Hz (target) tonal stimuli in quiet and in the presence of background noise at +20, +10, and 0 SNRs. P300 amplitudes and latencies were measured in each condition for every participant. Repeated measures analyses of variance were conducted for the amplitude and latency measures of the P300 for each group. Results: Results from this study demonstrated P300 latencies were significantly longer in older adults in noise at the most challenging condition (0 SNR) compared with the quiet condition and between the +10 SNR and 0 SNR conditions. Although older adults had significantly longer P300 latencies compared with younger adults, no significant group by listening condition interaction existed. No significant P300 amplitude differences were found for group, noise, or group × listening condition interactions. Conclusions: Results provide evidence that auditory cortical processing, regardless of age, is poorer at more difficult SNRs. However, results also demonstrate that older adults perform significantly poorer than younger adults. This supports the notion that some degree of age-related decline in synchronous firing and rate of transmission of the auditory cortical neurons contributing to the auditory P300 exists. Studies are needed to further understand the impact of noise on auditory cortical processing across populations.
Type A/B behavior and cancer mortality: The confounding/mediating effect of covariates

The role of stress and related factors in cancer etiology and progression has been a subject of conjecture and hypothesis. We analysed the association of type A/B behavior, which can be viewed as a chronic, repetitive stress response, and cancer mortality, using data from a 22‐year follow‐up of the Western Collaborative Group Study. The unadjusted relative hazard between type A/B behavior and total cancer mortality was 1.53 (p = 0.005), indicating an excess risk of cancer mortality in type A subjects of about 50% over that of type B. However, most or all of the association appeared to be confounded or mediated by other risk factors. Cigarette smoking and age were only weakly correlated with type A/B behavior, yet these two variables were so strongly related to cancer mortality that they accounted for about half of the association of type A/B with cancer mortality. The remaining association was found only for mortality of those cancers which are linked to alcohol consumption, suggesting that this remaining association may operate through a link between type A behavior and alcohol consumption. Thus, an unadjusted association between type A/B behavior and cancer mortality was mostly accounted for by cigarette smoking, age, and possibly alcohol consumption.
A new consideration on tendon-tension control system of robot hands

The authors discuss force control for the tendon-sheath driving system typically used to actuate robotic finger joints. For a simple tendon-sheath model, the transmission characteristics were first formulated with factors called the apparent tendon stiffness and equivalent backlash. An interesting aspect is that apparent tendon stiffness changes when the tendon is pulled or loosened, while tendon stiffness itself keeps constant under the absence of friction. This unexpected behavior is confirmed by simulations as well as experiments. The authors also consider the effect of apparent tendon stiffness on force control and show that the direction-dependent behavior of apparent tendon stiffness eventually brings about a direction-dependent response in the force control system. <<ETX>>
General Relationship for the Thermal Oxidation of Silicon

The thermal‐oxidation kinetics of silicon are examined in detail. Based on a simple model of oxidation which takes into account the reactions occurring at the two boundaries of the oxide layer as well as the diffusion process, the general relationship x02+Ax0=B(t+τ) is derived. This relationship is shown to be in excellent agreement with oxidation data obtained over a wide range of temperature (700°–1300°C), partial pressure (0.1–1.0 atm) and oxide thickness (300–20 000 A) for both oxygen and water oxidants. The parameters A, B, and τ are shown to be related to the physico‐chemical constants of the oxidation reaction in the predicted manner. Such detailed analysis also leads to further information regarding the nature of the transported species as well as space‐charge effects on the initial phase of oxidation.
Proteasomal Protein Degradation: Adaptation of Cellular Proteolysis With Impact on Virus—and Cytokine-Mediated Damage of Heart Tissue During Myocarditis

Viral myocarditis is an inflammation of the heart muscle triggered by direct virus-induced cytolysis and immune response mechanisms with most severe consequences during early childhood. Acute and long-term manifestation of damaged heart tissue and disturbances of cardiac performance involve virus-triggered adverse activation of the immune response and both immunopathology, as well as, autoimmunity account for such immune-destructive processes. It is a matter of ongoing debate to what extent subclinical virus infection contributes to the debilitating sequela of the acute disease. In this review, we conceptualize the many functions of the proteasome in viral myocarditis and discuss the adaptation of this multi-catalytic protease complex together with its implications on the course of disease. Inhibition of proteasome function is already highly relevant as a strategy in treating various malignancies. However, cardiotoxicity and immune-related adverse effects have proven significant hurdles, representative of the target's wide-ranging functions. Thus, we further discuss the molecular details of proteasome-mediated activity of the immune response for virus-mediated inflammatory heart disease. We summarize how the spatiotemporal flexibility of the proteasome might be tackled for therapeutic purposes aiming to mitigate virus-mediated adverse activation of the immune response in the heart.
Dexmedetomidine as an Adjuvant to Local Anesthetics in Transversus Abdominis Plane Block

Objectives: The objective of this meta-analysis was to evaluate the analgesic effects of dexmedetomidine (DEX) in transversus abdominis plane (TAP) blocks for abdominal surgery. Methods: Electronic databases, including PubMed, EMBASE, Chinese National Knowledge Infrastructure (CNKI), Wan Fang, and the Cochrane Library, were conducted to collect the randomized controlled trials (RCTs) from inception to March 2018. RCTs investigating the impact of adding DEX to local anesthetics for TAP blocks were included in this analysis. Pain scores (at rest and movement), opioid consumption, the duration of the TAP block and the common adverse effects were analyzed. Results: Twenty published trials including 1212 patients met the inclusion criteria. The addition of DEX significantly reduced pain scores 8 hours postoperatively at rest (WMD, −0.78; 95% CI, −1.27 to −0.30; P=0.001), 4 hours postoperatively on movement (WMD, −1.13; 95% CI, −1.65 to −0.60; P<0.001), and opioid consumption (WMD, −13.71; 95% CI, −17.83 to −9.60; P<0.001) when compared with control group. Furthermore, perineural DEX significantly prolonged the duration of the TAP block (WMD, 3.33; 95% CI, 2.85 to 3.82; P<0.001). It did not affect the incidence of postoperative nausea and vomiting, hypotension, bradycardia, somnolence, or pruritus. Conclusions: DEX is a potential anesthetic adjuvant that can facilitate better postoperative analgesia, reduce postoperative analgesic requirements, and prolong the local anesthetic effect when administered in TAP blocks.
Dynamics of Colon Monocyte and Macrophage Activation During Colitis

Background: Macrophages are pivotal in coordinating a range of important processes in the intestines, including controlling intracellular infections and limiting damaging inflammation against the microbiota. However, it is not clear how gut macrophages, relative to recruited blood monocytes and other myeloid cells, contribute to the intestinal inflammatory milieu, nor how macrophages and their monocyte precursors mediate recruitment of other immune cells to the inflamed intestine. Methods: Myeloid cell populations isolated from colonic inflammatory bowel disease (IBD) or murine dextran sulphate sodium (DSS) induced colitis were assessed using flow cytometry and compared to healthy controls. In addition, mRNA expression profiles in human and murine colon samples, and in macrophages and monocytes from healthy and inflamed murine colons, were analysed by quantitative PCR (qPCR) and mRNA microarray. Results: We show that the monocyte:macrophage balance is disrupted in colon inflammation to favour recruitment of CD14+HLA-DRInt cells in humans, and Ly6CHi monocytes in mice. In addition, we identify that murine blood monocytes receive systemic signals enabling increased release of IL-1β prior to egress from the blood into the colon. Further, once within the colon and relative to other myeloid cells, monocytes represent the dominant local source of both IL-1β and TNF. Finally, our data reveal that, independent of inflammation, murine colon macrophages act as a major source of Ccl7 and Ccl8 chemokines that trigger further recruitment of their pro-inflammatory monocyte precursors. Conclusions: Our work suggests that strategies targeting macrophage-mediated monocyte recruitment may represent a promising approach for limiting the chronic inflammation that characterises IBD.
Musical practice as an enhancer of cognitive function in healthy aging - A systematic review and meta-analysis

Aging is accompanied by cognitive decline, although recent research indicates that the rate of decline depends on multiple lifestyle factors. One of such factors is musical practice, an activity that involves several sensory and motor systems and a wide range of high-level cognitive processes. This paper describes the first systematic review and meta-analysis, to our knowledge, of the impact of musical practice on healthy neurocognitive aging. The inclusion criteria for the review required that studies were empirical works in English or Spanish that they explored the effects of musical practice on older people; they included an assessment of cognitive functions and/or an assessment of brain status; and they included a sample of participants aged 59 years or older with no cognitive impairment or brain damage. This review led to the selection of 13 studies: 9 correlational studies involving older musicians and non-musicians and 4 experimental studies involving short-term musical training programs. The results of the meta-analysis showed cognitive and cerebral benefits of musical practice, both in domain-specific functions (auditory perception) and in other rather domain-general functions. Moreover, these benefits seem to protect cognitive domains that usually decline with aging and boost other domains that do not decline with aging. The origin of these benefits may reside, simultaneously, in the specific training of many of these cognitive functions during musical practice (specific training mechanism), in the improvement of compensatory cognitive processes (specific compensatory mechanism), and in the preservation of general functions with a global influence on others, such as perceptual capacity, processing speed, inhibition and attention (general compensatory mechanism). Therefore, musical practice seems to be a promising tool to reduce the impact of cognitive problems associated to aging.
GarNet: A Two-Stream Network for Fast and Accurate 3D Cloth Draping

While Physics-Based Simulation (PBS) can accurately drape a 3D garment on a 3D body, it remains too costly for real-time applications, such as virtual try-on. By contrast, inference in a deep network, requiring a single forward pass, is much faster. Taking advantage of this, we propose a novel architecture to fit a 3D garment template to a 3D body. Specifically, we build upon the recent progress in 3D point cloud processing with deep networks to extract garment features at varying levels of detail, including point-wise, patch-wise and global features. We fuse these features with those extracted in parallel from the 3D body, so as to model the cloth-body interactions. The resulting two-stream architecture, which we call as GarNet, is trained using a loss function inspired by physics-based modeling, and delivers visually plausible garment shapes whose 3D points are, on average, less than 1 cm away from those of a PBS method, while running 100 times faster. Moreover, the proposed method can model various garment types with different cutting patterns when parameters of those patterns are given as input to the network.
Inhibition of MERTK Promotes Suppression of Tumor Growth in BRAF Mutant and BRAF Wild-Type Melanoma

Molecularly-targeted agents have improved outcomes for a subset of patients with BRAF-mutated melanoma, but treatment of resistant and BRAF wild-type tumors remains a challenge. The MERTK receptor tyrosine kinase is aberrantly expressed in melanoma and can contribute to oncogenic phenotypes. Here we report the effect of treatment with a MERTK-selective small molecule inhibitor, UNC2025, in preclinical models of melanoma. In melanoma cell lines, treatment with UNC2025 potently inhibited phosphorylation of MERTK and downstream signaling, induced cell death, and decreased colony formation. In patient-derived melanoma xenograft models, treatment with UNC2025 blocked or significantly reduced tumor growth. Importantly, UNC2025 had similar biochemical and functional effects in both BRAF-mutated and BRAF wild-type models and irrespective of NRAS mutational status, implicating MERTK inhibition as a potential therapeutic strategy in tumors that are not amenable to BRAF-targeting and for which there are limited treatment options. In BRAF-mutated cell lines, combined treatment with UNC2025 and the BRAF inhibitor vemurafenib provided effective inhibition of oncogenic signaling through ERK, AKT, and STAT6, increased induction of cell death, and decreased colony-forming potential. Similarly, in NRAS-mutated cell lines, addition of UNC2025 to cobimetinib therapy increased cell death and decreased colony-forming potential. In a BRAF-mutated patient-derived xenograft, treatment with combined UNC2025 and vemurafenib was well-tolerated and significantly decreased tumor growth compared with vemurafenib alone. These data support the use of UNC2025 for treatment of melanoma, irrespective of BRAF or NRAS mutational status, and suggest a role for MERTK and targeted combination therapy in BRAF and NRAS-mutated melanoma.
Creating Life: Or, Does Architecture Determine Anything?

As far as spatial layout is concerned the question of "architectural determinism" has two components: does spatial layout influence the pattern of space use and movement? and does this patterning of "spatial life" have social implications? In this paper, an attempt is made to answer the first question by, first, using space syntax to analyse generic properties of a large sample of towns and urban areas; and second, using the hypotheses derived from this analysis to explore the relation between spatial layout and movement patterns in a sample of real case studies of urban areas and housing estates. It is argued that the results show that spatial layout in itself generates a field of probabilistic encounter, with structural properties that vary with the syntax of the layout. Finally, it is argued that this encounter field may be a more important social and psychological factor than has been allowed.
A Novel Machine Learning Algorithm to Automatically Predict Visual Outcomes in Intravitreal Ranibizumab-Treated Patients with Diabetic Macular Edema

Purpose: Artificial neural networks (ANNs) are one type of artificial intelligence. Here, we use an ANN-based machine learning algorithm to automatically predict visual outcomes after ranibizumab treatment in diabetic macular edema. Methods: Patient data were used to optimize ANNs for regression calculation. The target was established as the final visual acuity at 52, 78, or 104 weeks. The input baseline variables were sex, age, diabetes type or condition, systemic diseases, eye status and treatment time tables. Three groups were randomly devised to build, test and demonstrate the accuracy of the algorithms. Results: At 52, 78 and 104 weeks, 512, 483 and 464 eyes were included, respectively. For the training group, testing group and validation group, the respective correlation coefficients were 0.75, 0.77 and 0.70 (52 weeks); 0.79, 0.80 and 0.55 (78 weeks); and 0.83, 0.47 and 0.81 (104 weeks), while the mean standard errors of final visual acuity were 6.50, 6.11 and 6.40 (52 weeks); 5.91, 5.83 and 7.59; (78 weeks); and 5.39, 8.70 and 6.81 (104 weeks). Conclusions: Machine learning had good correlation coefficients for predicating prognosis with ranibizumab with just baseline characteristics. These models could be the useful clinical tools for prediction of success of the treatments.
RF bandpass filter design based on CMOS active inductors

In this paper, a second-order RF bandpass filter based on active inductor has been implemented in a 0.35 /spl mu/m CMOS process. Issues related to the intrinsic quality factor and dynamic range of the CMOS active inductor are addressed. Tuned at 900 MHz with Q=40, the filter has 28-dB spurious-free-dynamic-range (SFDR) and total current consumption (including buffer stage) is 17 mA with 2.7-V power supply. Experimental results also show the possibility of using them to build higher order RF filter and voltage-controlled oscillator (VCO).
How You See Me

Convolution Neural Networks is one of the most powerful tools in the present era of science. There has been a lot of research done to improve their performance and robustness while their internal working was left unexplored to much extent. They are often defined as black boxes that can map non-linear data very effectively. This paper tries to show how CNN has learned to look at an image. The proposed algorithm exploits the basic math of CNN to backtrack the important pixels it is considering to predict. This is a simple algorithm which does not involve any training of its own over a pre-trained CNN which can classify.
Dataset Distillation

Model distillation aims to distill the knowledge of a complex model into a simpler one. In this paper, we consider an alternative formulation called dataset distillation: we keep the model fixed and instead attempt to distill the knowledge from a large training dataset into a small one. The idea is to synthesize a small number of data points that do not need to come from the correct data distribution, but will, when given to the learning algorithm as training data, approximate the model trained on the original data. For example, we show that it is possible to compress 60,000 MNIST training images into just 10 synthetic distilled images (one per class) and achieve close to original performance with only a few gradient descent steps, given a fixed network initialization. We evaluate our method in various initialization settings and with different learning objectives. Experiments on multiple datasets show the advantage of our approach compared to alternative methods.
Two sources of bias explain errors in facial age estimation

Accurate age estimates underpin our everyday social interactions, the provision of age-restricted services and police investigations. Previous work suggests that these judgements are error-prone, but the processes giving rise to these errors are not understood. Here, we present the first systematic test of bias in age estimation using a large database of standardized passport images of heterogeneous ages (n = 3948). In three experiments, we tested a range of perceiver age groups (n = 84), and found average age estimation error to be approximately 8 years. We show that this error can be attributed to two separable sources of bias. First, and accounting for the vast majority of variance, our results show an assimilative serial dependency whereby estimates are systematically biased towards the age of the preceding face. Second, younger faces are generally perceived to be older than they are, and older faces to be younger. In combination, these biases account for around 95% of variance in age estimates. We conclude that perception of age is modulated by representations that encode both a viewer's recent and normative exposure to faces. The finding that age perception is subject to strong top-down influences based on our immediate experience has implications for our understanding of perceptual processes involved in face perception, and for improving accuracy of age estimation in important real-world tasks.
Endogenous H2S production deficiencies lead to impaired renal erythropoietin production.

INTRODUCTION Patients suffering from chronic kidney disease (CKD) experience a number of associated comorbidities, including anemia. Relative deficiency in renal erythropoietin (EPO) production is thought to be a primary cause of anemia. Interestingly, CKD patients display low levels of hydrogen sulfide (H2S), an endogenously derived renal oxygen sensor. Previous in vitro experiments have revealed that H2S-deficient renal cell lines produce less EPO than wild-type renal cell lines during hypoxia. METHODS We postulated that H2S might be a primary mediator of EPO synthesis during hypoxia, which was tested using an in vivo murine model of whole-body hypoxia and in clinical samples obtained from CKD patients. RESULTS Following a 72-hour period of hypoxia (11% O2), partial H2S knockout mice (lacking the H2S biosynthetic enzyme cystathionine γ-lyase [CSE]) displayed lower levels of hemoglobin, EPO and cystathionine-β-synthase (CBS) (another H2S biosynthetic enzyme) compared to wild-type mice, all of which was rescued by exogenous H2S supplementation. We also found that anemic CKD patients requiring exogenous EPO exhibited lower urinary thiosulfate levels compared to non-anemic CKD patients of similar CKD classification. CONCLUSIONS Together, our results confirm an interplay between the actions of H2S during hypoxia and EPO production.