Miracle-dz/UniFAR-FTUs huggingface dataset:
Discriminatie is het woord niet: lesbische vrouwen en homoseksuele mannen op de werkvloer: bejegening en beleid

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THE METABOLOMIC EFFECTS OF METFORMIN ON COLON CANCER

OF DISSERTATION THE METABOLOMIC EFFECTS OF METFORMIN ON COLON CANCER Metformin is an oral biguanide that is prescribed to over 120 million people worldwide for the treatment of conditions including type II diabetes mellitus, polycystic ovarian syndrome, and gestational diabetes. This hypoglycemic agent is rapidly emerging as a potential cost-effective anti-oncogenic agent. Over the past decade multiple epidemiologic studies have consistently associated metformin with decreased cancer incidence and cancer-related mortality. More recently numerous preclinical and clinical studies have demonstrated anti-cancer effects of metformin, leading to the proposal of numerous clinical trials to better understand this drug and its mechanisms of action. Previously experts believed metformin primarily targeted AMP-activated protein kinase (AMPK), a crucial cellular energy sensor, but more recent data suggest the impact of metformin has a multi-faceted impact on various metabolic pathways. Current understanding of the potential anti-cancer effects of metformin raises the intriguing possibility of a duality of action, suggesting that metformin has the ability to act directly on a tumor while also indirectly lowering insulin levels in the host. This complexity creates challenges in determining the true impact of this drug in the clinical and translational setting. Despite an increase in investment, only one in every 10 new molecular therapeutic agents that enters clinical development receives approval from the Food and Drug Administration. This warrants a demand for better designed clinical trials with more elegant and robust analyses of relevant primary endpoints to determine which targeted therapies are cost-effective, and more importantly which agents will provide the best care for our patients. Stable isotope resolved metabolomics (SIRM) is a powerful tool capable of robust analyses that can address these questions. Using these capabilities we have determined that metformin does significantly impact cellular metabolism by shifting colon cancer cells into glycolytic overdrive, ultimately leading to decreased proliferation and protein synthesis in cancer cells. This study contributes to the literature and implores that we continue to elucidate the full potential of this drug, especially in the setting of personalized medicine where select patients may receive maximal benefit from this agent.
Television and Electronic Device Use and Overweight/Obesity Status: Children and Adolescents with and without Autism Spectrum Disorders

Because of its association with obesity, excessive “screen time” is a concern. Children and adolescents with autism spectrum disorders (ASD’s) have been found to spend much of their free time watching television more than children and adolescents without ASD’s. Thus, the purpose of the current study was to determine if the time spent watching television, videos, playing video games and using other electronic devices contributed to overweight and obesity status among children and adolescents with ASD’s compared to children and adolescents without ASD’s. The current study analyzed data (n = 95,677) that had been previously collected through the 2011/2012 National Survey of Children’s Health (NSCH). Children and adolescents with an ASD had significantly higher odds of being overweight or obese than children and adolescents without an ASD. Time watching television was a predictor of overweight/obesity status for children and adolescents both with ASD’s and without ASD’s. However, only children and adolescents with ASD’s who used electronic devices four or more hours per day were significantly more likely to be overweight/obese than those who did not use electronic devices. A discussion of the results and limitations of the study are also provided.
Recovery from Depression Using the Narrative Approach: A Guide for Doctors, Complementary Therapists and Mental Health Professionals

"Recovery from Depression Using the Narrative Approach" explores people's experiences of depression, recovery and available treatments. The author explains how, by choosing more helpful narratives, people can gain a greater insight into their depression, self-management and long-term recovery. By selecting a variety of 'narrative tools', such as talking therapies, yoga and complementary therapies, as well as conventional medical approaches, people can take better control of their condition. Written with a range of professionals in mind (and their clients) this evidence-based book offers specific guidance on how professionals can be an 'ally' in promoting patients' recovery.
Time Series Chaos Detection and Assessment via Scale Dependent Lyapunov Exponent

Many dynamical systems in a wide range of disciplines -- such as engineering, economy and biology -- exhibit complex behaviors generated by nonlinear components which might result in deterministic chaos. While in lab--controlled setups its detection and level estimation is in general a doable task, usually the same does not hold for many practical applications. This is because experimental conditions imply facts like low signal--to--noise ratios, small sample sizes and not--repeatability of the experiment, so that the performances of the tools commonly employed for chaos detection can be seriously affected. To tackle this problem, a combined approach based on wavelet and chaos theory is proposed. This is a procedure designed to provide the analyst with qualitative and quantitative information, hopefully conducive to a better understanding of the dynamical system the time series under investigation is generated from. The chaos detector considered is the well known Lyapunov Exponent. A real life application, using the Italian Electric Market price index, is employed to corroborate the validity of the proposed approach.
Large Phased Arrays Diagnostic via Distributional Approach

Abstract—A deterministic method for detecting faulty elements in phased arrays is proposed and tested against experimental and numerical data. The solution approach assumes as input the amplitude and phase of the near-field distributions and allows to determine both positions and currents of radiating elements. The corresponding non linear inverse problem is properly solved by exploiting the distributional approach, which allows to cast the initial problem to the solution of a linear one, whose solution is made stable by adopting a proper regularization scheme based on the Truncated Singular Value Decomposition tool. The results fully confirm accuracy of the proposed technique.
Improving Quality of Care in Acute Cardiology

textabstractAcute cardiac care has changed dramatically over the past decennia. In coronary care and general intensive care units, information technology was introduced for arrhythmia monitoring and other signal processing. More recently, information technology has been applied to assist clinical decision making. Chapter 1 provides a definition for clinical decision support systems (CDSS) in critical care and describes factors for successful implementation of such systems. Subsequent chapters present three groups of studies designed to improve patient care (I) using information technology to assist rapid diagnosis and treatment in patients with evolving myocardial infarction, (II) better managing the multitude of monitoring alarms and (III) improving glucose regulation in patients at an intensive cardiac care unit.
Theoretical approaches to written language: A TESOL perspective

About the book: Devised in collaboration with the Open University and Macquarie University, Australia, Analysing English in a Global Context is specifically designed for the postgraduate student market, as well as for teachers of English as a second or foreign language throughout the world. This is a groundbreaking Reader which includes specially commissioned pieces as well as classic texts and provides a global perspective on the changing uses and forms of English and its impact on language teaching contexts. Students' skills in analysing these forms will be developed through an examination of the major functional models and their strengths and weaknesses.
The optical mouse as a two-dimensional displacement sensor

Optical sensors are used extensively for displacement measurement. A cost-effective optical displacement sensor will be invaluable in applications where very high resolutions are not required. In this work, the optical mouse has been investigated to determine its suitability for two-dimensional displacement measurement. While the mouse worked only on objects with opaque surfaces, experiments conducted with a commercial unit with 0.0635 mm resolution showed that highly linear (average R 2 -value of 0.9914) and low error (mean square error (M.S.E.) value below 0.018 mm 2 ) measurements could be attained. On the ﬂipside, the unit could only operate if placed at a distance no greater than 1.25 mm from the object surface. Overall, the optical mouse has been found to be a viable two-dimensional displacement sensor. Its efﬁcacy was demonstrated in measuring the viscoelastic elongation of polyethylene.
Reversal of Dialysis-Dependent Renal Failure in a Patient With HIV-Associated Nephropathy: A Case Report

Human immunodeficiency virus–associated nephropathy (HIVAN) characterized by proteinuria and progressive renal failure is the single most common cause of chronic kidney disease in HIV-1–seropositive patients. In the pre–highly active antiretroviral therapy (HAART) era, HIVAN was associated with a progressive decline in renal function, culminating in end-stage renal disease requiring dialysis, and typically death secondary to renal failure, opportunistic infection, or other HIV-related end-organ failure. The treatment of this condition is still controversial, but corticosteroids, angiotensin-converting enzyme inhibitors, and HAART have reduced the rate of progression. As yet, there have been no prospective, randomized, controlled trials that document beneficial effect of HAART or of other medical therapies. We report a patient with dialysis-dependent chronic kidney disease secondary to HIVAN who was able to stop dialysis 2 months after initiation of HAART therapy combined with corticosteroids. (Infect Dis Clin Pract 2007;15:415–418) Human immunodeficiency virus (HIV)–associated nephropathy (HIVAN) is a syndrome caused by focal sclerosing glomerulopathy and typically presents with severe proteinuria, renal failure, and rapid progression to end-stage renal disease (ESRD). It is the most common cause of ESRD in HIV-1–seropositive patients. Human immunodeficiency virus–associated nephropathy is much more likely in patients of African descent,2 – 5 which suggests an interaction between underlying genetic factors and HIV. The prevalence of HIVAN in HIV-positive patients has been estimated from 3.5% in clinical studies to 12% in autopsy studies. The risk factors include a CD4 cell count of less than 200 cells/mm and a high viral burden. It has also been documented in patients with acute HIV infection. A prior study reported biopsy-proven HIVAN in patients with undetectable viral loads. The treatment of this condition has been focused on the use of highly active antiretroviral therapy (HAART), angiotensin-converting enzyme (ACE) inhibitors, and corticosteroids. The prognosis of HIVAN without adequate treatment is poor. Cases have been documented in which initiation of antiretroviral treatment led to remission within a few weeks. Although there is strong observational data supporting the importance of HAART in the treatment of HIVAN, there are no prospective randomized and controlled trials that support the use of HAART in these patients. We report a patient with dialysis-dependent chronic kidney disease secondary to HIVAN who was able to stop dialysis 2 months after initiation of HAART therapy combined with corticosteroids.
On the Quadratic Bundles Related to Hermitian Symmetric Spaces

Communicated by Alexandar B. Yanovski Abstract. Here we develop the direct scattering problem for quadratic bundles associated to Hermitian symmetric spaces. We adapt the dressing method for quadratic bundles which allows us to find special solutions to multicomponent derivative Schrodinger equation for instance. The latter is an infinite dimensional Hamiltonian system possessing infinite number of integrals of motion. We demonstrate how one can derive them by block diagonalization of the corresponding Lax pair.
Solar radiation affects grapevine susceptibility to Plasmopara Viticola

Solar radiation plays an important role in the development of some fungal diseases due to its direct action on the microorganisms and also its indirect effect on the production of specific plant compounds. This experiment examined the effect of two light environments (100% and 35% of full strength) on the polyphenolic content of grapevine leaves and quantified their relation to resistance to downy mildew (Plasmopara viticola). Leaf epidermal polyphenolic contents were non-destructively measured during the growing season 2006 using the Dualex chlorophyll fluorescence-based portable leaf-clip. The experimental design consisted of six parcels of 30 vines and measurements were performed on the 12 central vines. The leaves were inoculated with a sporangia suspension containing 50,000 sporangia of P. viticola per mL and the disease severity was assessed after the appearance of symptoms. Leaves maintained at 100% sun had high polyphenolic content and significantly lower disease severity compared to leaves under shading nets. These results indicate an inverse relationship between produced polyphenolics and downy mildew severity.
Bioelectricity Production and Comparative Evaluation of Electrode Materials in Microbial Fuel Cells Using Indigenous Anode-Reducing Bacterial Community from Wastewater of Rice-Based Industries

Microbial fuel cells (MFCs) are the electrochemical systems that harness the electricity production capacity of certain microbes from the reduction of biodegradable compounds. The present study aimed to develop mediator-less MFC without using expensive proton exchange membrane. In the present study, a triplicate of dual-chamber, mediator-less MFCs was operated with two local rice based industrial wastewater to explore the potential of this wastewater as a fuel option in these electrochemical systems. 30 combinations of 6 electrodes viz. Carbon (14 cm × 1.5 cm), Zn (14.9 cm × 4.9 cm), Cu (14.9 cm × 4.9 cm), Sn (14.1cm × 4.5cm), Fe (14cm × 4cm) and Al (14cm × 4.5 cm) were evaluated for each of the wastewater samples. Zn-C as anode-cathode combination produced a maximum voltage that was 1.084±0.016V and 1.086±0.028 and current of 1.777±0.115mA and 1.503±0.120 for KRM and SSR, respectively. In the present study, thick biofilm has been observed growing in MFC anode. Total 14 bacterial isolates growing in anode were obtained from two of the wastewater. The dual chambered, membrane-less and mediator-less MFCs were employed successfully to improve the economic feasibility of these electrochemical systems to generate bioelectricity and wastewater treatment simultaneously. Keywords : Membrane-less, Microbial Fuel Cells, Biofilm, Wastewater, Electrogenic. Article History : Received June 25 th 2016; Received in revised form Dec 15 th 2016; Accepted January 5 th 2017; Available online How to Cite This Article : Reena, M. and Jadhav, S. K. (2017) Bioelectricity production and Comparative Evaluation of Electrode Materials in Microbial Fuel Cells using Indigenous Anode-reducing Bacterial Community from Wastewater of Rice-based Industries. International Journal of Renewable Energy Develeopment, 6(1), 83-92. http://dx.doi. org/10.14710/ijred.6. 1.83-92
Web-based Peer Tutoring in Science Education

Peer-instruction has been shown to have a very positive effect on students’ engagement and learning. PeerWise is a web-tool designed to allow peer-tutoring between students within a large class group. Students can write, answer and discuss Multiple Choice Questions (MCQs) based on their work in-class. It is low-cost and low-maintenance software which has become increasingly popular across many subject disciplines as a method to introduce a peer-tutoring aspect to course work. In this study we introduce PeerWise as a form of continuous assessment to a wide and varied cohort of science students (N=509) across disciplines, undergraduate years, levels (certificate to honours degree) and institutes. Correlations between engagement with PeerWise and an increase in end of module exam results are investigated and found to be strongly correlated in one of the modules investigated. Students’ attitudes to PeerWise are probed with a number of Likert style questions. It is found that the students agree that the tool benefits their understanding through the peer-activities of authoring and answering questions and to a lesser degree by discussion of questions with classmates. Some differences exist between class groups but overall the engagement levels across all groups are much higher than the minimum requirement set by the assessments.
Working profile of Australian private practice Accredited Practising Dietitians

Aim To describe the demographic, operational and financial working profile of private practice dietitians in Australia. Methods A cross-sectional online survey examined the demographics, business structure, key services and fees, marketing strategies, financial welfare, professional support and motivation for dietitians working in the private practice sector in Australia. A link to the survey was posted on the Dietitians Association of Australia, Dietitians In the Private Sector Interest Group national list serve, from September to October 2011 (potential reach of 1222 members). Reminder emails were posted every seven days; data collection ceased after 28 days. Results A total of 156 dietitians completed the online survey, representing a response rate of 13%. The majority were female, aged 20–30 years. Seventy-four per cent of the dietitians identified themselves as the proprietor of the business in which they worked. Eighty-four per cent of the respondents had prior dietetic experience before entering private practice, mainly in the hospital/clinical setting. Most dietitians conducted <20 consultations per week, with the main source of referrals being general practitioners. Initial consultations were on average 52 ± 13 minutes in length (range 30–120 minutes) and incurred a fee of $99 ± 22 (range $60–$195). For dietitians renumerated on a ‘per-hour’ basis (41%), the gross hourly rate was $71 ± $35 (range $20–$135). For those renumerated on a ‘percentage of income generated’ basis (44%), the rate was 52 ± 23% (range 15–89%). Conclusions The present study provides valuable data on the working profile of private practice dietitians in Australia, which will inform support and advocacy for this working group.
Self-Regulatory Efficacy and Mindset of At-Risk Students: An Exploratory Study

There is a limited body of research examining how students’ beliefs about intelligence and about their abilities relate to different learning environments. As reported here, I examined secondary school students’ beliefs, goals, and expectations guided by Zimmerman’s (2000) model of self-regulated learning. In this exploratory study, 230 secondary school students reported on their beliefs about learning and intelligence, as well as on their confidence in their self-regulatory abilities. I made comparisons between groups of students on beliefs, goals, and expectations based on their school stream, achievement, learning disability status, and gender. Both self-regulatory efficacy and reading mindset were significantly different for students based on their school stream and their achievement level. The findings of this exploratory study suggest a need for further research that focuses directly on whether at-risk students demonstrate maladaptive motivation and specifically on their beliefs, goals, and expectations of themselves as learners. ISSN 1918-5227 Pages 6790 Follow this and additional works at: http://ir.lib. uwo.ca/eei This Article (Subscription-only) is brought to you by Scholarship@Western. It has been accepted for inclusion in Exceptionality Education International by an authorized administrator of Scholarship@Western. For more information, please contact jspecht@uwo.ca. Recommended Citation Matheson, I. A. (2015) Self-Regulatory Efficacy and Mindset of At-Risk Students: An Exploratory Study. Exceptionality Education International, 25, 67-90. Retrieved from http://ir.lib. uwo.ca/eei/vol25/iss1/4 Exceptionality Education International 2015, Vol. 25, No. 1, pp. 67–90 ISSN 1918-5227 67 Self-Regulatory Efficacy and Mindset of At-Risk Students: An Exploratory Study
Housing market differentiation: the cases of Yenimahalle and Çankaya in Ankara

This study aims to investigate housing market differentiation, drawing upon the results of case studies of the Cankaya and Yenimahalle districts that adopt a set of statistical techniques. As a first step, a cluster analysis is carried out to identify whether identifiable clusters of housing attributes exist on the basis of neighborhoods. Next, a Multiple Discriminant Analysis (MDA) is applied to investigate the differences between clusters, and to understand which housing attributes contribute most to submarket separation. Finally, a hedonic price analysis is conducted for each cluster and for the overall market to identify price differences in the housing market. The results of the study support the hypothesis that the housing market is segmented in Yenimahalle and Cankaya, and that location is the main determining factor in this segmented structure of different house values. The study also reveals that within this segmented structure, each cluster has its own dynamics, and that the price formation in each cluster is dependent on different variables.
STUDY OF KNOWLEDGE, ATTITUDE AND PRACTICE OF PHARMACIST TOWARDS ADVERSE DRUG REACTION REPORTING IN DAVANGERE CITY

Objective: To study the knowledge, attitude, and practice of pharmacists towards adverse drug reaction (ADR) reporting in Davangere city. Method: A prospective and questionnaire-based study, conducted for a period of 6 months in different pharmacies of Davangere city. The sample includes 145 pharmacists. Result: Among 145 pharmacists approached, 102 (response rate is 70.34%) pharmacists agreed to give the consent for study. Majority of them were male (90.2%). Out of these respondents, only 15 (14.7%) pharmacists knew the correct definition of ADR. Only 32 (31%) were aware of Pharmacovigilance Programme of India. 77 (75.4%) agreed that pharmacists could be the right person to assist physician in ADR reporting. Seventyfive (73.53%) respondents felt that ADR reporting has good outcome and 82 (80.4%) thought that they are not adequately trained in ADR reporting. Conclusion: Majority of pharmacists have poor knowledge, but positive attitude towards ADR reporting. Incorporation of ADR reporting concepts in education curriculum, training of pharmacists and voluntary participation of pharmacists in ADR reporting is very vital in safe guarding the public health. Keywords: Adverse drug reactions, Pharmacists, Knowledge, Attitude, Questionnaires.