Miracle-dz/UniFAR-FTUs huggingface dataset:
Cost-aware request routing in multi-geography cloud data centres using software-defined networking

Current geographically distributed cloud data centres (CDCs) require gigantic energy and bandwidth costs to provide multiple cloud applications to users around the world. Previous studies only focus on energy cost minimisation in distributed CDCs. However, a CDC provider needs to deliver gigantic data between users and distributed CDCs through internet service providers (ISPs). Geographical diversity of bandwidth and energy costs brings a highly challenging problem of how to minimise the total cost of a CDC provider. With the recently emerging software-defined networking, we study the total cost minimisation problem for a CDC provider by exploiting geographical diversity of energy and bandwidth costs. We formulate the total cost minimisation problem as a mixed integer non-linear programming (MINLP). Then, we develop heuristic algorithms to solve the problem and to provide a cost-aware request routing for joint optimisation of the selection of ISPs and the number of servers in distributed CDCs. Besides, to tackle the dynamic workload in distributed CDCs, this article proposes a regression-based workload prediction method to obtain future incoming workload. Finally, this work evaluates the cost-aware request routing by trace-driven simulation and compares it with the existing approaches to demonstrate its effectiveness.
Prevalence of Uterine and Adnexal Involvement in Pulmonary Lymphangioleiomyomatosis: A Clinicopathologic Study of 10 Patients

Lymphangioleiomyomatosis (LAM), a systemic disorder affecting almost exclusively young women, is characterized by the abnormal proliferation of smooth muscle-like cells (LAM cells). LAM can occur either in association with the tuberous sclerosis complex (TSC) (TSC-LAM) or without TSC (sporadic LAM). Recent studies have demonstrated that LAM is a neoplasm arising from constitutive activation of the mammalian target of rapamycin signaling pathway dysregulated by a functional loss of TSC genes, but the primary organ of origin remains unclear. Therefore, we performed histologic and immunohistologic analyses of gynecologic organs in 20 patients, half with and the other half without pulmonary LAM, to determine how often LAM involves the uterus. The results showed that 9 of 10 (90%) patients with pulmonary LAM had uterine LAM lesions. In contrast, no patients without pulmonary LAM had so. All uterine LAM lesions were accompanied by LAM lesions in retroperitoneal or pelvic lymph nodes and LAM cell clusters, each enveloped by a monolayer of vascular endothelial growth factor receptor-3–positive lymphatic endothelial cells. Furthermore, when we compared uterine lesions of TSC-LAM with those of sporadic LAM, proliferation of HMB45-positive epithelioid-shaped LAM cells and infiltrates with a tongue-like growth pattern was more prominent in the former, whereas the extent of lymphangiogenesis within the myometrium was greater in the latter. These results indicate that uterine involvement is a common manifestation of LAM, and, possibly, that the uterus or an adjacent locale in the retroperitoneum or pelvic cavity is the primary site of origin of LAM.
Linguistic analysis of patients with mood and anxiety disorders during cognitive behavioral therapy

Abstract We analyzed the verbal behavior of patients with mood or/and anxiety disorders during psychotherapy. Investigating the words people used, we expected differences due to cognitive and emotional foci in patients with depression vs. anxiety. Transcripts of therapy sessions from 85 outpatients treated with cognitive behavioral therapy were analyzed using the software program Linguistic Inquiry and Word Count. Multivariate group comparisons were carried out investigating the LIWC-categories first-person-singular pronouns, sad, anxiety and fillers. Differences between the three diagnostic groups were found in verbal utterances related to sadness (p = .05). No differences were found for first-person-singular pronouns and content-free fillers. Comparing the distinct groups “depression” and “anxiety”, depressed patients used more words related to sadness (p = .01). Mood and anxiety disorders differ in the experience of emotions, but only slightly in self-focused attention. This points to differences in language use for different diagnostic groups and may help to improve diagnostic procedures or language-driven interventions which enhance therapists’ attention to patients’ verbal behavior.
On-Chip Memory Based Binarized Convolutional Deep Neural Network Applying Batch Normalization Free Technique on an FPGA

A pre-trained convolutional deep neural network (CNN) is a feed-forward computation perspective, which is widely used for the embedded systems, requires highly power-and-area efficiency. This paper proposes a binarized CNN on an FPGA which treats only binary 2-values∼(+1/-1) for the inputs and the weights. In this case, the multiplier is replaced into an XNOR circuit instead of a dedicated DSP block. For hardware implementation, using binarized inputs and weights is more suitable. However, the binarized CNN requires the batch normalization techniques to retain the classification accuracy. In that case, the additional multiplication and addition require extra hardware, also, the memory access for its parameters reduces system performance. In this paper, we propose a batch normalization free binarized CNN which is mathematically equivalent to one using batch normalization. The proposed CNN treats the binarized inputs and weights with the integer bias. We implemented the VGG-16 benchmark CNN on the Xilinx Inc. Zynq UltraScale+ MPSoC zcu102 evaluation board. Our binarized CNN stores all the weights, inputs, and output to on-chip BRAMs those are faster and dissipate lower power than an off-chip memory, such as a DDR4SDRAM. Compared with the conventional FPGA realizations, although the classification accuracy is 6.5% decayed, the performance is 2.45 times faster, the power efficiency is slightly better, and the area efficiency is 2.68 times better. Compared with the ARM Cortex-A57, it is 136.8 times faster, it dissipates 3.1 times much power, and its performance per power efficiency is 44.7 times better. Also, compared with the Maxwell embedded GPU, it is 4.9 times faster, it dissipates 1.3 times much power, and its performance per power efficiency is 3.8 times better. Thus, our method is suitable for the embedded computer system.
Some Nutritional Characteristics of Fruit and Oil of Walnut (Juglans regia L.) Growing in Turkey

Walnut (Juglans regia L.) were evaluated for some physical properties and chemical composition. Ripe fruits were determined for moisture (2.71 %), crude protein (14.6 %) crude fibre (1.8 %) ash (1.57 %), crude energy (576 Cal) ether soluble extract (24.71 %), nut (10.5 g) and kernel (5.09 g) veights. Relative density, refractive index, free fatty acids, peroxide value, saponification number, unsaponifiable matter were established in the walnut oil. The main fatty acids identified by gas chromatography were palmtic (6,4 %) oleic (13.4 %), linoleic (55,3 %) and linolenic (8,7 %) acids. The mineral contents of walnuts were established by using Inductively Coupled Plasma Atomic Emission Spectroscopy (ICP-AES). Contents of A1, Ca, Fe, K, Mg, Mn, Na, P, Se and Zn were also determined in the fruits. The work attempts to contribute to knowledge of the nutritional properties of walnut kernels. The fruits were found to be rich in protein, oil, fibre, unsaturated fatty acids and minerals. These results may be useful for the evaluation of dietary information.
Critical role of Nrf2 in oxidative stress‐induced retinal ganglion cell death

NF‐E2 related factor 2 (Nrf2) is a key transcription factor that plays a pivotal role in endogenous protection against oxidative stress. However, the role of Nrf2 in visual disorders remains unclear. It has been reported that oxidative stress is thought of as one of the causes of glaucoma. Here, we investigate whether the function of Nrf2 in oxidative stress‐induced retinal ganglion cell (RGC) death. This study used adult male Nrf2 deficient mice (Nrf2 KO) and age‐ and sex‐matched wild‐type (WT) mice. We dissociated and purified N‐4‐[4‐didecylaminostryryl]‐N‐methyl‐pyridinium iodide‐labeled RGCs with fluorescence‐activated cell sorting, and tried to detect the Nrf2 and Keap1 genes. In the absence of nerve crush (NC), the number of RGCs in Nrf2 KO mice was almost same as that in WT mice. 1‐(2‐cyano‐3‐, 12‐dioxooleana‐1, 9 (11)‐dien‐28‐oyl) imidazole (CDDO‐Im), an Nrf2 activator, prevented NC‐induced loss of RGCs in WT mice. Seven days after NC, without treatment, the number of RGCs in Nrf2 KO mice was significantly lower than in WT mice. In addition, after CDDO‐Im treatment, quantitative RT‐PCR showed increased expression of antioxidant and phase II detoxifying enzymes. These results suggest that up‐regulation of Nrf2 signaling after CDDO‐Im treatment may be a novel therapeutic strategy for the protection of RGCs, especially in glaucoma.
Living with an amputation: What it means for patients and their helpers

The social and emotional problems declared by 134 single-leg amputees are compared with those of 109 people who were their main helpers. The Day Amputee Activity Score, the Goldberg GHQ, Townsend's Social Isolation scale and Forder's concept of Felt Need were used in the study. The majority of patients were elderly males. Most of the carers were women. Peripheral vascular disease was the most frequent reason for the amputation and its persistence postoperatively was predictive of poor rehabilitation outcome. The respondents reported unmet need for information about financial help, employment and social activity. Both groups shared a high level of social isolation, which was associated with risk of psychiatric illness and appeared to inhibit the expression of need. Helpers complained more forcefully than patients about service provision and discussed their emotional reactions more readily. The amputees tended to use denial in confronting the implications of limb ablation. Many respondents had no sources of help with personal or practical problems. Their knowledge of available services was poor. In particular, the role of social workers was not well understood. Neither the social work profession nor the Artificial Limb Centre was used to any appreciable extent as a source of help with psychosocial adjustment to loss of a limb.
Immune Thrombocytopenia in Tuberculosis: Causal or Coincidental?

Immune thrombocytopenia is a relatively rare hematological manifestation in tuberculosis. We report two cases of immune thrombocytopemia, one in sputum positive pulmonary tuberculosis and the other in miliary tuberculosis. Antituberculous drugs and immunosuppressive therapy corrected the thrombocytopenia in both patients. Our case reports stress that tuberculosis should be considered during the evaluation of immune thrombocytopenia, and also highlights the safety of immunosuppressive therapy during active tuberculosis along with antituberculous drugs.
Ethical Considerations in Qualitative Research with Vulnerable Groups: Exploring Lesbians' and Gay Men's Experiences of Health Care – A Personal Perspective

It is rare to find honest accounts of the difficulties and dilemmas encountered when conducting sensitive research with vulnerable research populations. This account explores some of the ethical issues raised by a qualitative interview study with lesbians and gay men about their experiences of nursing care. There is tension between the moral duty to conduct research with vulnerable and stigmatized groups in order to improve care, and the inevitable lack of resources that go with such a venture. This increases the risk of harm during the process of research. The risk of harm to both the researchers and the researched is explored and the need for a support structure for both groups is raised. There is a pressing need to develop further understanding about the ways in which the dissemination of research can potentially harm already vulnerable research populations.
Resuscitation and withdrawal of therapy in pediatric intensive care.

Although issues concerning withdrawal and limitation of life support are commonly discussed,1-6 actual practices in pediatrics are largely unknown and are limited to neonatal intensive care unit (ICU) studies. In the neonatal ICUs at Yale-New Haven Hospital and at Hammersmith Hospital, 14% and 30%, respectively, of all deaths followed withdrawal of care.7,8 In adult ICUs, limitation and/or withdrawal of therapy is common,9 and in one investigation, resuscitation was not attempted immediately before ICU death in nearly two-thirds of cases.10 Nonetheless, many physicians believe that most hospital deaths occur only after all resuscitative attempts have failed,6,11,12 and others believe that resuscitative efforts neither are indicated nor desirable in many cases.1,13
Anaplasma phagocytophilum-Borrelia burgdorferi Coinfection Enhances Chemokine, Cytokine, and Matrix Metalloprotease Expression by Human Brain Microvascular Endothelial Cells

ABSTRACT Borrelia burgdorferi and Anaplasma phagocytophilum coinfect and are transmitted by Ixodes species ticks. Clinical indicators suggest that A. phagocytophilum coinfection contributes to the severity, dissemination, and, possibly, sequelae of Lyme disease. Previous in vitro studies showed that spirochete penetration through human brain microvascular endothelial cells of the blood-brain barrier is facilitated by endothelial cell-derived matrix metalloproteases (MMPs). A. phagocytophilum-infected neutrophils continuously release MMPs and other vasoactive biomediators. We examined B. burgdorferi infection of brain microvascular barriers during A. phagocytophilum coinfection and showed that coinfection enhanced reductions in transendothelial electrical resistance and enhanced or synergistically increased production of MMPs (MMP-1, -3, -7, -8, and -9), cytokines (interleukin 6 [IL-6], IL-10, and tumor necrosis factor alpha), and chemokines (IL-8 and macrophage inflammatory protein 1α) known to affect vascular permeability and inflammatory responses.
DNA Macrorestriction Analysis of Nontypeable Group B Streptococcal Isolates: Clonal Evolution of Nontypeable and Type V Isolates

ABSTRACT Group B streptococci (GBS) are serotyped according to capsular polysaccharide (CPS) type (Ia to VIII); an isolate is classified as nontypeable (NT) if no detectable CPS is found. Surface-localized protein antigens (α, β, R1, and R4) serve as additional markers to classify GBS isolates, which is particularly useful since NT isolates often express one or more of these proteins. To compare genetic resemblance among isolates with similar protein profiles, we studied 58 NT isolates digested with the SmaI macrorestriction enzyme prior to pulsed-field gel electrophoresis (PFGE). Of these 58, 15.5% expressed α only, 20.7% expressed α+β, 15.5% expressed R4, and 25.8% expressed R1,R4, while 22.4% of the isolates expressed no detectable proteins. The largest PFGE profile group, with 48% of the isolates, was group 4, composed primarily of isolates that expressed R1,R4 or no proteins. The second most common profiles were 3 and 32, each with 13.8% of the isolates. Since NT isolates in profile group 4 were highly related to type V isolates, as demonstrated by PFGE profiles, we investigated 45 type V isolates. Two-thirds of the type V isolates within profile group 4 were classified into subgroup 4a, compared to 28.2% of 39 NT isolates. Only 11% of the V/R1,R4 isolates were identical to the prototype group 4 profile, in contrast to 75% of the NT/R1,R4 isolates. A shift of type V isolates into profile 4 subgroups may be indicative of a genetic change over time. PFGE is a valuable approach for comparison of GBS isolate relatedness and for monitoring of NT and typeable GBS isolates for potential clonal divergence.
Pregnancy-associated malaria in a rural community of ghana.

OBJECTIVES Pregnant women in malaria-endemic communities are susceptible to Plasmodium falciparum infections, with adverse consequences including maternal anaemia, placental malaria parasitaemia and infant low birth weight (LBW). We sought to assess the prevalence, incidence, and clinical markers of pregnancy-associated malaria (PAM) in a rural district of Ghana. METHODS A total of 294 pregnant women were enrolled and followed passively and actively, monthly and weekly until delivery. Haemoglobin levels, malaria parasitaemia and Hb electrophoresis were done from peripheral blood samples. At delivery, placental smears were examined for malaria parasites. RESULTS Prevalence of peripheral blood P. falciparum parasitaemia at enrolment was 19.7% and related to parity. Incidence rate of parasitaemia was 0.06 infections/ person/month [95% confidence interval (CI): 0.04 to 0.08]. Symptomatic infections rose sharply from the first trimester to the last. Prevalence of malaria parasites in the placenta was 35.9% (61/170) and highest among primigravidae (P(chi(2))=0.006). Incidence of LBW infants was 17.7% (30/170), most common among those with placental P. falciparum infection (P(chi(2))=0.005) corresponding to a relative risk of 2.8 [1.4 to 5.2]. Median infant birth weight in those with placental infection was significantly lower than in those without infections (P(chi(2))=0.001). Maternal haemoglobin levels were lower (9.7 [9.3-10.1] g/dL) at enrolment, among women who subsequently had placental P. falciparum infection than among those who did not have placental infection at delivery (10.5 [10.2-10.8] g/dL) (P (t)=0.003). CONCLUSION Primigravidae and secundigravidae are significantly at risk of developing PAM, and low haemoglobin during pregnancy is a clinical indicator of placental P. falciparum infection.
The Role of Supportive Messages and Distracting Thoughts on Everyday Problem-Solving Performance

Background/Study Context: An increasing number of studies have examined factors related to everyday problem-solving performance across adulthood. The current study examined the role of experimentally provided supportive messages intended to provide practical or emotional support on everyday problem-solving performance. Other factors such as participant age and distracting thoughts experienced during task completion were also investigated. Methods: Everyday problem-solving performance, verbal ability performance, inductive reasoning performance, and self-reports of distracting thoughts were obtained from 54 middle-aged and 48 older adults. Participants were also exposed to practically supportive messages, emotionally supportive messages, or no supportive messages prior to completing the everyday problem-solving task. Results: Exposure to emotionally supportive messages increased task performance and lowered levels of distracting thoughts. Distracting thoughts mediated the relation between exposure to emotionally supportive messages and everyday problem-solving performance. Distracting thoughts also mediated the relation between age and everyday problem-solving performance. Conclusion: Study findings indicate that emotionally supportive messages may increase everyday problem-solving performance by decreasing the amount of distracting thoughts experienced by participants. This finding suggests that consistent administration of emotionally supportive messages could result in more optimal everyday problem-solving performance among middle-aged and older adults.
Color, cooking properties and texture of yellow alkaline noodles enriched with millet and corn flour.

The objective of this study was to investigate the effect of corn flour and millet flour on color, cooking properties and texture of yellow alkaline noodle (YAN). Corn flour and millet flour were added to wheat flour at different level viz. 0, 5, 10, 20, 30% (w/w), respectively. The color, cooking properties, texture and sensory value of these sample noodles were tested. The results showed that corn flour and millet flour almost had same effect on qualities of YAN. The L* value of fresh noodle declined slightly as the addition level of corn and millet flour were increased. The yellow index b* value increased with addition level of corn or millet flour, maximal at 30%. The ratio of broken-down noodle, water uptake and cooking lose increased with increase in the addition level of corn and millet flour. The ratio of broken-down noodle exceeds 10% when the addition level was beyond 10% (w/w). Total sensory score and noodle adhesiveness, firmness and tensile declined as the addition level was increased. On the basis of color, textural and sensory characteristics, the addition level at 5-10% (w/w) was found to be acceptance for the preparation of corn or millet blending flour YAN.
Relationship between High-Sensitivity C-Reactive Protein and Clinical Functional Outcome after Acute Ischemic Stroke in a Korean Population

Background: High-sensitivity C-reactive protein (hs-CRP) has been shown to be a powerful predictor of coronary ischemic events. However, the prognosis of functional disability in patients with cerebrovascular disease has not been well established. Therefore, we performed this study to determine the prognostic significance of hs-CRP levels in patients with functional disability after acute ischemic stroke. Methods: A total of 417 Korean patients with ischemic stroke were examined within 24 h after symptom onset. hs-CRP measurements were obtained on admission and on the seventhhospital day. The correlations between the concentration of hs-CRP and functional disability duration 12 months after stroke onset were analyzed. Results: The present study showed that hs-CRP levels on admission and on the seventh hospital day were significantly correlated with the modified Rankin Scale (mRS) score 12 months after stroke onset. These results also demonstrated that mRS scores are more closely associated with hs-CRP levels on the seventh hospital day than hs-CRP levels on admission. Conclusion: This study demonstrated that elevated hs-CRP levels on the seventh hospital day, rather than within 24 h after stroke onset, could strongly predict the prognosis of functional disability. These results supported that hs-CRP is a useful marker of ischemic stroke in the Korean population.