Miracle-dz/UniFAR-FTUs huggingface dataset:
MORE: A multi‐objective refactoring recommendation approach to introducing design patterns and fixing code smells

Refactoring is widely recognized as a crucial technique applied when evolving object‐oriented software systems. If applied well, refactoring can improve different aspects of software quality including readability, maintainability, and extendibility. However, despite its importance and benefits, recent studies report that automated refactoring tools are underused much of the time by software developers. This paper introduces an automated approach for refactoring recommendation, called MORE, driven by 3 objectives: (1) to improve design quality (as defined by software quality metrics), (2) to fix code smells, and (3) to introduce design patterns. To this end, we adopt the recent nondominated sorting genetic algorithm, NSGA‐III, to find the best trade‐off between these 3 objectives. We evaluated the efficacy of our approach using a benchmark of 7 medium and large open‐source systems, 7 commonly occurring code smells (god class, feature envy, data class, spaghetti code, shotgun surgery, lazy class, and long parameter list), and 4 common design pattern types (visitor, factory method, singleton, and strategy). Our approach is empirically evaluated through a quantitative and qualitative study to compare it against 3 different state‐of‐the art approaches, 2 popular multiobjective search algorithms, and random search. The statistical analysis of the results confirms the efficacy of our approach in improving the quality of the studied systems while successfully fixing 84% of code smells and introducing an average of 6 design patterns. In addition, the qualitative evaluation shows that most of the suggested refactorings (an average of 69%) are considered by developers to be relevant and meaningful.
Is vibration exercise a useful addition to a weight management program?

Vibration exercise (VbX) has received a lot of attention as an exercise modality, which evokes muscular work and elevates metabolic rate that could be a potential method for weight reduction. Popular press has purported that VbX is quick and convenient, and 10 min of VbX is equivalent to 1 h of traditional exercise, where it has been marketed as the new weight‐loss and body toning workout. However, research studies have shown that muscle activation occurs but the energy demand in response to VbX is quite low, where exhaustive VbX reported a metabolic demand of 23 mL/kg/min compared with 44 mL/kg/min from an exhaustive cycle test. Different vibration frequencies with varying amplitudes and loads have been tested, but only small increases in metabolic rate have been reported. Based on these findings, it has been indirectly calculated that a VbX session of 26 Hz for three continuous minutes would only incur a loss of ∼10.7 g fat/h. Following a 24‐week program of VbX, no observed differences were found in body composition, and following 12 months of VbX, the time to reach peak V ˙ O 2 was significantly higher in conventional exercise compared with VbX. However, one study has reported that percentage body fat decreased by 3.2% after 8 months after VbX in comparison with resistance and control groups that performed no aerobic conditioning. The evidence to date suggests that VbX can increase whole and local oxygen uptake; however, with additional load, high vibration frequency, and/or amplitude, it cannot match the demands of conventional aerobic exercise. Therefore, caution is required when VbX programs are solely used for the purpose of reducing body fat without considering dietary and aerobic conditioning guidelines.
Involvement of T 1 R 3 in calcium-magnesium taste

Tordoff MG, Shao H, Alarcón LK, Margolskee RF, Mosinger B, Bachmanov AA, Reed DR, McCaughey S. Involvement of T1R3 in calcium-magnesium taste. Physiol Genomics 34: 338–348, 2008. First published July 1, 2008; doi:10.1152/physiolgenomics.90200. 2008. — Calcium and magnesium are essential for survival but it is unknown how animals detect and consume enough of these minerals to meet their needs. To investigate this, we exploited the PWK/PhJ (PWK) strain of mice, which, in contrast to the C57BL/6J (B6) and other inbred strains, displays strong preferences for calcium solutions. We found that the PWK strain also has strong preferences for MgCl2 and saccharin solutions but not representative salty, sour, bitter, or umami taste compounds. A genome scan of B6 PWK F2 mice linked a component of the strain difference in calcium and magnesium preference to distal chromosome 4. The taste receptor gene, Tas1r3, was implicated by studies with 129.B6ByJ-Tas1r3 congenic and Tas1r3 knockout mice. Most notably, calcium and magnesium solutions that were avoided by wild-type B6 mice were preferred (relative to water) by B6 mice null for the Tas1r3 gene. Oral calcium elicited less electrophysiological activity in the chorda tympani nerve of Tas1r3 knockout than wild-type mice. Comparison of the sequence of Tas1r3 with calcium and saccharin preferences in inbred mouse strains found 1) an inverse correlation between calcium and saccharin preference scores across primarily domesticus strains, which was associated with an I60T substitution in T1R3, and 2) a V689A substitution in T1R3 that was unique to the PWK strain and thus may be responsible for its strong calcium and magnesium preference. Our results imply that, in addition to its established roles in the detection of sweet and umami compounds, T1R3 functions as a gustatory calcium-magnesium receptor.
HTLV-I virological and histopathological analysis in two cases of anti-centromere-antibody-seropositive Sjögren’s syndrome

IntroductionThe aim of this study was to show the clinical and pathological characteristics of anti-centromere-antibody (ACA)-seropositive Sjögren’s syndrome (SS) in two anti-human T-cell leukemia virus type I (HTLV-I)-seropositive patients.MethodsOne patient was an HTLV-I carrier whereas the other was diagnosed with HTLV-I-associated myelopathy (HAM). Background data including serum HTLV-I titers, viral loads, and cytokine profiles were recorded. Azocarmine with aniline blue (Azan)–Mallory staining and immunohistochemistry of the labial salivary glands (LSGs) and a muscle biopsy specimen from the HAM patient were performed.ResultsSerum transforming growth factor beta (TGF-β), tumor necrosis factor alpha (TNF-α), and HTLV-I viral load were high in the HAM-SS patient compared with the HTLV-I carrier. Fibrous change in LSG was prominent in the HAM-SS patient. Although TGF-β expression was similar in the two patients, expression of HTLV-I-related proteins including p12, p28, group-specific antigen (GAG), and nuclear factor kappa-B (NF-κB) in the LSG were dominantly detected in the HAM-SS patient. Frequency of TGF-β staining in HTLV-I-seropositive SS patients without ACA, HTLV-I-seronegative SS patients with ACA, and HTLV-I-seronegative SS patients without ACA was lower than that of the previous two patients.ConclusionA high HTLV-I viral load in situ is supposed to promote the production of cytokines, especially TGF-β, resulting in the fibrous change of LSG in ACA-seropositive SS patients.
Effects of dose and period of neonatal alcohol exposure on the context preexposure facilitation effect.

BACKGROUND Alcohol exposure in the rat on postnatal days (PD) 4 to 9 is known to partially damage the hippocampus and to impair hippocampus-dependent behavioral tasks. We previously reported that PD4 to 9 alcohol exposure eliminated the context preexposure facilitation effect (CPFE) in juvenile rats, a hippocampus-dependent variant of contextual fear conditioning. In the CPFE, context exposure and immediate shock occur on successive occasions and this produces conditioned freezing relative to a control group that is not preexposed to the training context. Here, we extend our earlier findings by examining the effects of neonatal alcohol administered at multiple doses or over different neonatal exposure periods. METHOD Rat pups (male and female) were exposed to a single binge dose of alcohol at one of 3 doses (2.75, 4.00, or 5.25 g/kg/d) over PD4 to 9 (Experiment 1) or to 5.25 g over PD4 to 6 or PD7 to 9 (Experiment 2). Sham-intubated (SI) and undisturbed (UD) rats served as controls. On PD31, rats were preexposed to either the training context (Pre) or an alternate context (No-Pre). On PD32, rats received an immediate unsignaled footshock (1.5 mA, 2 seconds) in the training context. Finally, on PD33, all rats were returned to the training context and tested for contextual freezing over a 5-minute period. RESULTS Undisturbed- and SI-Pre rats showed the CPFE, i.e., context preexposure facilitated contextual conditioning, relative to their No-Pre counterparts. The immediate shock deficit was present in all No-Pre groups, regardless of previous alcohol exposure. In Experiment 1, blood alcohol level was negatively correlated with contextual freezing. Group 2.75 g-Pre did not differ from controls. Group 4.00 g-Pre froze significantly less than Groups UD- and SI-Pre but more than Group 5.25-Pre, which showed the immediate shock deficit. In Experiment 2, alcohol exposure limited to PD7 to 9, but not PD4 to 6, disrupted the CPFE. CONCLUSIONS This is the first demonstration of dose-related impairment on a hippocampus-dependent task produced by neonatal alcohol exposure in the rat. Exposure period effects support previous studies of alcohol and spatial learning. The CPFE is a more sensitive behavioral task that can be used to elucidate developmental alcohol-induced deficits over a range of alcohol doses that are more relevant to human exposure levels.
The Surgical Management of Cervical Spinal Stenosis, Spondylosis, and Myeloradiculopathy by Means of the Posterior Approach

No firm statistical evidence exists establishing the superiority of the anterior or the posterior approach in the management of spondylostenosis, although some sense of order is evolving. In general the consensus suggests that in spondylostenosis, the anterior approach may be preferred for disc or segmental osteophyte intrusions limited to one or two levels. Laminectomy is the preferred procedure in patients with a narrowed canal and multiple level involvement. The surgeon's personal preference and experience remains the dominant factor. Patients with congenital stenosis involving all of the major segments, with or without superimposed developmental changes, require more extensive laminar decompression with proper attention to the craniocervical junction where anomalies may occur. The success of laminectomy is dictated by the preservation of cervical lordosis. In patients with major dorsally located abnormalities such as hyperlordosis, shingling, and arthrosis with hypertrophy of the yellow ligaments, posterior decompression is essential. Subsequent stabilization is rarely required with proper surgical and postoperative care. Both an anterior and posterior approach may be indicated in unique circumstances of spondylostenosis complicated by subluxation and instability.
Prepulse technique for producing low-Z Ne-like x-ray lasers.

We report an application of the prepulse technique which uses a low-intensity prepulse before the main optical drive pulse to prepare the plasma prior to lasing in low-[ital Z], Ne-like ions. Ne-like x-ray lasers are now available over a previously inaccessible range of wavelengths. As an illustration of this technique we report an observation of lasing in Cr[sup 14+] and Fe[sup 16+] on the Ne-like [ital J]=0[r arrow]1, 3[ital p][r arrow]3[ital s] transitions at 285 and 255 A as well as gain measurements for Ti[sup 12+].
An Exploratory Study on Apparel Distribution system and its Countermeasure in the view of Market Liberalization

The channel of distribution exists for the purpose of moving product from the manufactuerer to the final consumer. In order to satisfy consumer needs, channels provide for the those products to arrive at the right place, at the right time and in the quantity, quality and price desired. Currently, there has been an emerging interest in the improvement of distribution system in many areas of industries and Korean government because of a market liberalizatiion begun at 1989 and still has processed step by step. In the wave of market liberalization, an understanding of the channel of distribution and structure would be very crucial when developing the opportunities of competitive advantages in Korean apparel industry. The purposes of this study were to investigate the determinants of the distribution channel and to identify how to respond to the market liberalization for developing the possible future strategies in the apparel industry. Data for this study were obtained from interviews with managers in apparel company in addition to a questionnaire mailed to over 106 middle management position of apparel company. Data were analyzed by using descriptive statistics. The results of this study were summarized as follows. 1. In the distribution channel of the apparel industry, a vertical marketing system, comprising producer, apparel company, retailer, prevailed without intermediaries such as wholesalers or vendors. Especially, the apparel company controlled marketing channel members. This type of system may reflect added product cost and may be not advantageous to retailers and consumers because most apparel companies are responsible for its own transfortation, storage and stocks after season. 2. In the view of market liberalization, most apparrel companies showed double-edged viewpoints. In terms of positive aspect, it would give stimulus to broaden variety of fashion merchandise and to improve product quality of fashion merchanise which were the most disadvantageous factors in competing with oversea's brands. In terms of negative aspect, it would bring the bankruptcy of small or medium sized apparel firms and the foreign products' penetration in domestic market. From this study, severel recommedations were suggested forward to improve the present condition in apparel industry. They included eliminating the power of apparel company and reinforcing middlemen for more efficient distribution system and for satisfying consumer needs in rapidly changing environment. Also it included government supports, reinforcement of information system, improvement in channel structure, and career development program in conjunction with apparel companies and academic society for improving scientific management and future potential strategies in Korean apparal industry.
Screening for PS1 mutations in a referral-based series of AD cases

Background: Mutations in the presenilin-1 gene (PS1) account for a majority of patients with early-onset familial AD. However, the clinical indications and algorithms for genetic testing in dementia are still evolving. Methods: The entire open reading frame of the PS1 gene was sequenced in a series of 414 consecutive patients referred for diagnostic testing, including 372 patients with AD and 42 asymptomatic persons with a strong family history of AD. Results: Forty-eight independent patients screened had a PS1 mutation including 21 novel mutations. In addition, 3% of subjects (11/413) had a known polymorphism, the Glu318Gly substitution. The majority of the mutations were missense substitutions but there were three insertions and Δexon 10 mutation. With six exceptions (codons 35, 178, 352, 354, 358, and 365) most of the mutations occurred at residues conserved in the homologous PS2 gene or in PS1 of other species. Conclusions: Eleven percent of a referral-based series of patients with AD can be explained by coding sequence mutations in the PS1 gene. The high frequency of PS1 mutations in this study indicates that screening for PS1 mutations in AD is likely to be successful, especially when directed at patients with a positive family history with onset before 60 years (90% of those with PS1 mutations were affected by age 60 years). This will also have significance for the secondary identification of at-risk relatives who might be candidates for future prophylactic therapies for AD.
Opioid-Involved Overdose Among Male Afghanistan/Iraq-Era U.S. Military Veterans: A Multidimensional Perspective

ABSTRACT Background: Mirroring nationwide trends in a broad range of U.S. populations, an alarming number of Afghanistan/Iraq-era U.S. Military veterans have experienced opioid-related overdoses. A growing body of research has examined the proximal behaviors that can precipitate an overdose; considerably less is known about more distal physiological, psychosocial and structural influences on these risk behaviors. Objectives: This study adopts a multidimensional approach to better understand opioid-related overdose among U.S. Military veterans, and seeks to explore not only the proximal behavioral precipitants of overdose events, but also the complex nexus of physiological, psychological, and sociological influences that undergird overdose events. Methods: This qualitative examination is based on interview data from 36 male veterans who were discharged from the military after September 2001 and experienced at least one opioid-related overdose during or after military service. Participants were recruited in New York City during 2014 to share narrative accounts of their overdoses. Results: Veterans' accounts indicate that background experiences, such as self-medication for social and psychological pain, trauma, social alienation and isolation, and histories of illicit drug use, precondition the more immediate factors and behaviors that precipitate overdose (including bingeing on drugs, mixing drugs, naiveté about dosage, and ambivalence about life/death). Conclusions: Findings suggest the need for comprehensive drug safety and overdose education that is sensitive to veterans' physiological, psychological, and sociological conditions. A multidimensional understanding of the distal and proximal overdose risks faced by veterans and other vulnerable groups may help lay a foundation for more inclusive/holistic approaches to overdose prevention and education.
Privacy in occupational health practice: Promoting and impeding factors

Aim: This article describes the views of occupational health professionals, employees, and employers on factors that are thought to promote and impede privacy in occupational health practice. Methods: The data were collected through theme interviews with 44 subjects and were analysed by content analysis. Results: Both promoting and impeding factors organized around two content areas: ``caregiving'' (patient—caregiver relationship) and ``tripartite cooperation'' (cooperation between occupational health professionals, employees, and employer). The content areas illustrated the two different roles Finnish occupational health professionals have toward their two groups of clients: employees and employers. ``Adequate behaviour'' (respect, good communication, presence) and ``Adequate knowledge base'' (instinct, work experience, ethical thinking, knowledge of legislation) promoted privacy in caring relationship, whereas ``Inadequate behaviour'' (untrustworthy, busy, distant, ``friend'') impeded its realization. In tripartite cooperation, the promoting factors had to do with ``Common good'' (impartiality, regular contacts, community spirit, fair play) and ``Individual good'' (informed consent, advocacy). The main category, ``Confusions in loyalties'', emerged from three subcategories (confusions in confidentiality, confusions in duties, and confusions in roles) illustrating the impeding factors in tripartite cooperation. Conclusions: Questions of privacy are crystallized in occupational health professionals' diverse duties and roles towards employees and employers. In occupational health practice, privacy cannot be seen only as a privilege of employees, but must also be viewed as an instrumental value serving the interests of employers and whole work community. Confusions in loyalties need more discussion and research before privacy can be optimally realized. Lapses in confidentiality should never happen.
Effect of Variable Rates of Daily Sampling of Fly Larvae on Decomposition and Carrion Insect Community Assembly: Implications for Forensic Entomology Field Study Protocols

ABSTRACT Experimental protocols in forensic entomology successional field studies generally involve daily sampling of insects to document temporal changes in species composition on animal carcasses. One challenge with that method has been to adjust the sampling intensity to obtain the best representation of the community present without affecting the said community. To this date, little is known about how such investigator perturbations affect decomposition-related processes. Here, we investigated how different levels of daily sampling of fly eggs and fly larvae affected, over time, carcass decomposition rate and the carrion insect community. Results indicated that a daily sampling of <5% of the egg and larvae volumes present on a carcass, a sampling intensity believed to be consistent with current accepted practices in successional field studies, had little effect overall. Higher sampling intensities, however, slowed down carcass decomposition, affected the abundance of certain carrion insects, and caused an increase in the volume of eggs laid by dipterans. This study suggests that the carrion insect community not only has a limited resilience to recurrent perturbations but that a daily sampling intensity equal to or <5% of the egg and larvae volumes appears adequate to ensure that the system is representative of unsampled conditions. Hence we propose that this threshold be accepted as best practice in future forensic entomology successional field studies.
Globalization and the Evolution of the Supply Chain: Who Gains and Who Loses?

This article focuses on two distinct facets of globalization: decrease in the trade costs of goods and the decline of communication costs between headquarters and production facilities. When the unskilled have about the same wage in two regions, decrease of these costs fosters the agglomeration of plants in the core accommodating headquarters. When the wage gap is significant, process of integration eventually triggers the relocation of plants into the periphery. When this process of relocation is driven by falling communication costs, the welfare of all workers in the core falls whereas that in the periphery rises.
Familial risk for distress and fear disorders and emotional reactivity in adolescence: an event-related potential investigation

Background The late positive potential (LPP) is an event-related potential component that is sensitive to the motivational salience of stimuli. Children with a parental history of depression, an indicator of risk, have been found to exhibit an attenuated LPP to emotional stimuli. Research on depressive and anxiety disorders has organized these conditions into two empirical classes: distress and fear disorders. The present study examined whether parental history of distress and fear disorders was associated with the LPP to emotional stimuli in a large sample of adolescent girls. Method The sample of 550 girls (ages 13.5–15.5 years) with no lifetime history of depression completed an emotional picture-viewing task and the LPP was measured in response to neutral, pleasant and unpleasant pictures. Parental lifetime history of psychopathology was determined via a semi-structured diagnostic interview with a biological parent, and confirmatory factor analysis was used to model distress and fear dimensions. Results Parental distress risk was associated with an attenuated LPP to all stimuli. In contrast, parental fear risk was associated with an enhanced LPP to unpleasant pictures but was unrelated to the LPP to neutral and pleasant pictures. Furthermore, these results were independent of the adolescent girls’ current depression and anxiety symptoms and pubertal status. Conclusions The present study demonstrates that familial risk for distress and fear disorders may have unique profiles in terms of electrocortical measures of emotional information processing. This study is also one of the first to investigate emotional/motivational processes underlying the distress and fear disorder dimensions.