Miracle-dz/UniFAR-FTUs huggingface dataset:
Application of the fuzzy‐oil‐drop model to membrane protein simulation

The analysis of structural properties and biological activity of membrane proteins requires long lasting simulation of molecular dynamics. The large number of atoms present in protein molecule, membrane (phospholipids), and water environment makes the simulation of large scale. The implementation of simplified model representing the natural environment for membrane proteins is presented and compared with the vacuum simulation and simulation in the presence of water molecules and membrane phospholipids presented explicite. The comparative structural analysis and computational times for these three models makes the simplified model promising. Proteins 2009. © 2009 Wiley‐Liss, Inc.
Kinesio Tape and Shoulder-Joint Position Sense.

CONTEXT Joint position sense (JPS) is a key neuromuscular factor for developing and maintaining control of muscles around a joint. It is important when performing specialized tasks, especially at the shoulder. No researchers have studied how Kinesio Tape (KT) application affects JPS. OBJECTIVE To investigate the effects of KT application and no tape on shoulder JPS at increasing shoulder elevations in athletes. DESIGN Cross-sectional study. SETTING University laboratory. PATIENTS OR OTHER PARTICIPANTS A total of 27 healthy athletes who did not participate in overhead sports (age = 20.44 ± 1.05 years, height = 175.02 ± 11.67 cm, mass = 70.74 ± 9.65 kg) with no previous pathologic shoulder conditions volunteered for the study. All participants were from 1 university. INTERVENTION(S) Shoulder JPS was assessed at increasing elevations with and without KT application. Participants attempted to actively replicate 3 target positions with and without the KT and without visual guidance. MAIN OUTCOME MEASURE(S) We examined absolute and variable repositioning errors at increasing shoulder-elevation levels with and without KT application. RESULTS Data revealed an interaction between tape and position for absolute error (F2,52 = 4.07, P = .02); simple effects revealed an increase in error, with KT demonstrating a 2.65° increase in error at 90° of elevation compared with no tape (t26 = 2.65, P = .01). The effect size was medium (ω(2) = . 135). Variable error showed no interaction of tape and position (F2,52 = .709, P = .50). Further analysis of simple effects was not needed. However, we still calculated the effect size and observed small effect sizes for tape (ω(2) = . 002), position (ω(2) = . 072), and tape by position (ω(2) = . 027). CONCLUSIONS At 90° of elevation, shoulder JPS was impaired by the application of KT.
Association of clinical progression in classic Kaposi's sarcoma with reduction of peripheral B lymphocytes and partial increase in serum immune activation markers.

OBJECTIVE To evaluate various immunologic markers in the peripheral blood of patients with early and advanced classic Kaposi's sarcoma (CKS). DESIGN Cross-sectional study. SETTING A major referral center for skin and venereal diseases. PATIENTS Sixty-eight patients with histologically confirmed CKS staged according to a modified version of the Mitsuyasu-Groopman classification in stage I-II (cutaneous involvement only) and stage IV (skin and systemic involvement). MAIN OUTCOME MEASURES Concentrations of neopterin and beta2-microglobulin, titer of anti-human herpesvirus 8 antibodies, number of natural killer cells, and numbers of total lymphocytes, B lymphocytes, T lymphocytes, and their subsets in peripheral blood. RESULTS The median values of beta2-microglobulin and neopterin were elevated in patients with CKS in stage IV (median, 3.679 microg/mL [312.72 nmol/L] and 14.0 nmol/L, respectively) compared with patients in stage I-II (median, 2.406 microg/mL [204.51 nmol/L] and 6.5 nmol/L, respectively). A statistically significant reduction in total lymphocyte and B-lymphocyte counts was observed in patients with advanced-stage CKS (1679/microL and 79/microL, respectively) compared with patients in earlier stages of the disease (2142/microL and 224/microL, respectively). The human herpesvirus 8 antibody titer, determined by latent immunofluorescent assay, decreased from stage I-II to stage IV, although not at a statistically significant level (P = .14). CONCLUSION The evolution of CKS from the early stages of the disease to the more advanced may be associated with a partial activation of the immune system and a gradual decrease in the number of total and B lymphocytes.
Cellular Communication in Clone 9 Cells Exposed to Magnetic Fields

Abstract Griffin, G. D. , Williams, M. W. and Gailey, P. C. Cellular Communication in Clone 9 Cells Exposed to Magnetic Fields. Magnetic-field exposure (45 Hz Ba.c. over a flux density range of 7.7 to 49.9 μT r.m.s. with parallel Bd.c. of 36.6 μT) has been reported by Blackman and coworkers to inhibit gap junction intercellular communication in Clone 9 cells treated with chloral hydrate for 24 h prior to field exposure in accord with predictions of the ion parametric resonance model. The study reported here is an attempt to reproduce this effect. Baseline experiments showed that growth in culture and state of confluence at time of addition of chloral hydrate were comparable in both laboratories. PMA inhibited cell–cell communication in a dose-dependent manner, similar to the results of Blackman and coworkers, whereas cells in the present study were somewhat more sensitive to chloral hydrate than reported by Blackman and coworkers. A total of 38 exposure experiments were undertaken using a 45 Hz magnetic field with a flux density of 23.8 μT r.m.s., in parallel with a 36.6-μT static magnetic field for 40 to 45 min, after pretreatment with 2.5 mM chloral hydrate for 24 h. In 14 unblinded experiments, a small but statistically significant effect of magnetic-field exposure was observed, but due to the subjective nature of the assay, it was deemed essential to carry out blinded experiments. The remaining 24 experiments were blinded. In 15 blinded experiments, cells purchased from the American Type Culture Collection and grown only in this laboratory were used, while in 9 experiments, the cells had originally been grown in Blackman's laboratory and were subsequently sent to this laboratory. There was no statistically significant effect of magnetic-field exposure on gap junction intercellular communication in these blinded experiments using either cell line.
Interferon System in Cells from Human Tumors and from Persons Predisposed to Cancer

In the present study, the interferon system was evaluated in fibroblasts from persons predisposed to leukemia or other cancers, in fibroblasts from persons with neoplastic disease, and in human tumor cells. Of 31 normal fibroblast strains from patients with tumors or diseases associated with a high incidence of malignancy, only one cell strain had a poor response to either of the two interferon inducers used, polyinosinic-polycytidylic acid and Chikungunya virus. On the other hand, cell cultures of five human tumors were much less sensitive to the antiviral effect of these interferon inducers and of human interferon and produced less interferon in response to Chikungunya virus than any of the nontumor tissues studied.
EFFICACY OF TACROLIMUS FOR INDUCTION OF REMISSION IN PATIENTS WITH MODERATE-TO-SEVERE ULCERATIVE COLITIS: A SYSTEMATIC REVIEW AND META-ANALYSIS.

BACKGROUND There is evidence that shows that calcineurin inhibitors may be useful for the treatment of severe ulcerative colitis. However, evidence regarding the efficacy of tacrolimus for remission induction in this setting is scarce. OBJECTIVE To develop a systematic review on the existing evidence regarding the clinical efficacy of tacrolimus for the induction of remission in patients with moderate-to-severe ulcerative colitis. METHODS A literature search was undertaken from 1966 to August 2016 using MEDLINE, Embase, LILACS and the Cochrane Library. The following MeSH terms were used: "Inflammatory Bowel Diseases" or "Ulcerative Colitis" and "Calcineurin Inhibitors" or "Tacrolimus" or "FK506". Studies performed in adult ulcerative colitis patients that evaluated the clinical efficacy of tacrolimus for the induction of remission were considered for revision. A meta-analysis was performed with those included studies that were also placebo-controlled and randomized. Clinical response as well as clinical remission and mucosal healing were evaluated. RESULTS Overall, 755 references were identified, from which 22 studies were finally included. Only two of them were randomized, placebo-controlled trials. A total of 172 patients were evaluated. A significantly lower risk of failure in clinical response was found for tacrolimus versus placebo [RR 0.58 (0.45-0.73)]; moreover, a lower risk of failure in the induction of remission was also found versus placebo [RR 0.91 (0.82-1)]. CONCLUSION Tacrolimus seems to be a valid therapeutic alternative for the induction of remission in patients with moderate-to-severe ulcerative colitis.
[Analysis of myocardial proteomic alteration after Qishenyiqi formula treatment in acute infarcted rat hearts].

OBJECTIVE Use proteomic technique to research the effects of Qishenyiqi formula in acute myocardial infarcted rats, and further explore its protein-level mechanism. METHOD The rat hearts of sham, myocardial infarcted and Qishenyiqi formula treated groups were collected. Analyzing and comparing the differences of protein expressions in each groups with two-dimensional electrophoresis, computer-assisted image analysis and matrix-assisted laser desorption/ionization mass spectrometry. RESULT Compared with myocardial infarcted group, there were 14 protein expressions changed in Qishenyiqi formula treated group. The result showed that 9 protein expressions were up-regulated, and 5 ones were down-regulated significantly. These proteins are associated with energy metabolism, mitochondrial function, oxidative stress, cytoskeleton and others. CONCLUSION Myocardial protective effects of Qishenyiqi formula in myocardial infarcted procedure might be closely related to the recovery of energy supply, the reduction of oxidative stress, as well as the promotion of cell recovery.
Cimicifuga racemosa treatment and health related quality of life in post-menopausal Spanish women

Objective. The effect of Cimicifuga racemosa (CR) treatment was evaluated in healthy symptomatic post-menopausal women using the Cervantes health-related quality of life (HR-QoL) scale. Design. A prospective observational study was carried out in 122 healthy symptomatic post-menopausal Spanish women with elevated body weight, aged between 45 and 59 years. Three groups were formed according to age intervals. Each patient completed the Cervantes HR-QoL scale before and after CR treatment (20 mg, twice a day for 3 months). Changes in Cervantes scale global quality of life scores as well as in their domains (menopause and health, psychic, sexuality and couple relationship) were analysed. Results. The CR treatment ameliorated global quality of life in both the whole group of patients and when women were analysed by age subgroups. There were significant positive changes in Z scores for the Cervantes HR-QoL scale ‘menopause and health’, and ‘psychic’ domains in both the entire population and by age groups. The ‘sexuality domain’ significantly improved when the entire population was assessed, but not when each age-group was separately analysed; while there were no changes in ‘couple relationship domain’ scores. Conclusion. CR treatment increased both global quality of life and the four domains of the Cervantes HR-QoL scale, being an effective treatment to reduce symptoms in post-menopausal woman with elevated body weight.
Profiles of musculoskeletal injuries among Greek Army officer cadets during basic combat training.

OBJECTIVE Injury prevalence and types of injury were recorded among Greek Army officer cadets during basic combat training (BCT). METHODS Two hundred thirty-three male recruits from the Hellenic Army Academy were monitored for musculoskeletal injuries during a 7-week BCT period. RESULTS Sixty-six (28.3%) recruits suffered from some form of injury, leading to 1.22 training days lost per study recruit. More than half of the injuries (51.3%) occurred in the first 2 weeks of the BCT, with ankle/foot strains and sprains being the most common injuries. CONCLUSION Despite the absence of fractures and the low number of upper extremity injuries during the BCT, injury prevalence was high, with ankle- and foot-related injuries to be responsible for a long period of lost training days. Preventive efforts should focus on addressing the high rate of first-time and recurrent ankle ligament sprains and possible protective equipment to limit their frequency and severity.
THE BORN GLOBAL FIRMS IN BRAZIL AND THE ROLE OF EXPORT- PROMOTION PROGRAMS

Este artigo teve como objetivo analisar os drivers internos e externos de empresas Born Global com as características de quatro pequenas empresas brasileiras da indústria coureiro-calçadista para identificar o papel dos programas oficiais de apoio na rápida internacionalização dessas empresas. Para tanto, foi realizado um estudo de casos múltiplos com quatro PMEs: Francesca Giobbi, LeatherTec, Gueto Ecodesign e Best Calçados e Componentes. O domínio de ativos intangíveis e únicos, a atuação em nichos de mercado e a orientação internacional dos fundadores foram os principais drivers internos relacionados à rápida internacionalização das empresas. Percebeu-se que os fundadores das 04 PMEs têm conhecimento sobre programas de promoção de exportações, mas esse driver externo não teve impacto na velocidade e no desempenho de internacionalização das empresas. Esse reforça a ideia de que a orientação internacional do executivo está associada ao conhecimento sobre programas oficiais de apoio, mas isso não significaria o seu uso e impacto na velocidade da internacionalização.
The production of novel root compounds in children with specific language impairment

This study examined ten children with specific language impairment (SLI), 16 normally developing children, and ten adults for the production of novel root compounds. The participants were asked to invent names for pictures of 24 pairs of contrasting, novel objects. For half of the pictures, the context supported a grammatical novel root compound, 16 contexts supported only an ungrammatical compound, and eight contexts supported a marginally grammatical compound. All participants used novel root compounds in grammatical contexts and relatively few compounds in ungrammatical contexts. The children with SLI used the information presented in the experimental probes less frequently than the normal controls. In addition, the children with SLI made more word‐order errors in their production of novel compounds. However, they were as likely as their normal counterparts to resist the use of regular plural markers within compounds. The results of this study support a difficulty associated with processing linguistic information on the part of the children with SLI.
Unilateral Tonsillar Enlargement and Tonsillar Lymphoma in Children

The clinical presentation and surgical and pathological findings of 46 children with unilateral tonsillar enlargement (UTE; age range 2 to 13 years, mean age 6.5) who underwent tonsillectomy for biopsy purposes between 1975 and 1995 were compared with those of 7 children who received treatment for tonsillar lymphoma (TL; age range 2 to 9 years, mean age 4.8) during the same period. There was no history of rapid tonsillar enlargement in children in the UTE group, and only 20 (43%) were symptomatic. Symptoms included recurrent sore throats in 10 patients (22%), snoring in 5 (11%), nasal obstruction in 4 (9%), and dysphagia in 1 (2%). No children had systemic symptoms or significant cervical lymphadenopathy. In contrast, tonsillar enlargement was observed to occur within a 6-week period in all children with TL, and 6 (86%) children had symptoms at presentation that included dysphagia in 5 (71%), snoring in 3 (43%), night sweats in 2 (29%), and fever and rigors in 2 (29%). Cervical lymphadenopathy greater than 3 cm was present in 6 (86%) children, while 1 child (14%) had hepatosplenomegaly. There was no histopathologic evidence of neoplasia in the UTE group, and a true discrepancy in size between the two tonsils was confirmed in only 21 of 44 (48%) cases. All 7 patients in the TL group had non-Hodgkin's lymphoma. All received chemotherapy, with 5 of the 7 cured and 2 dying of disease. The data suggest that tonsillectomy should be performed for biopsy purposes in UTE where there is a history of progressive enlargement, significant upper aerodigestive tract symptoms, systemic symptoms, suspicious appearance of the tonsil, cervical lymphadenopathy, or hepatosplenomegaly. The diagnosis of TL should also be considered when UTE is present in an immunocompromised child or one with a previous malignancy, when acute tonsillitis is asymmetric and unresponsive to medical treatment, or when rapid bilateral tonsil enlargement occurs. Observation is appropriate management for other cases of UTE.
The diagnosis of retinoblastoma.

R ETINOBLASTOMA is a potentially fatal cancer of early childhood. Its correct diagnosis can save a life, salvage one or both eyes, and even retain part or full vision. 1 This paper will review features of retinoblastoma that lead to a correct diagnosis and will emphasize both the common and unusual modes of presentation.
Glucose turnover in kelp bass ( ParaZabrcr ; x sp . ) : in vivo studies with [ 6-3 H , 6-14 C ] glucose

BEVER, KAREN, MAYMIE CHENOWETH, AND ARNOLD DUNN. Glucose turnover in kelp bass (Paralabrax sp.): in vivo studies with [6-3H,6-1T]glucose. Am. J. Physiol. 232(l): R66,R72, 1977 or Am. J. Physiol. : Regulatory Integrative Comp. Physiol. l(1): R66-R72, 1977. [6-3H,6-14C]glucose was injected via an indwelling arterial cannula in free-swimming, fed, and fasted kelp bass to determine hepatic glucose production, peripheral glucose uptake, minimal glucose mass, mean transit time, and the’percent of carbon recycling under the two different nutritional states. Mean plasma glucose levels remained unchanged in fed and fasted fish (48 t 8 vs. 43 * 8 mg/lOO ml). During steady-state conditions, glucose replacement rates of fed and fasted fish determined with [6-3H]glucose are similar (0.035 2 0.006 vs. 0.025 t 0.003 mg/min per 100 g) and do not differ from rates determined with [6-14C]glucose (0.035 t 0.005 vs. 0.026 t 0.002). The minimal glucose masses and the mean transit times determined with both isotopes are also similar suggesting that plasma glucose levels and glucose turnover are maintained in fish fasted up to 40 days with no apparent increase in carbon recycling. Nonsteady-state isotope experiments suggest that these fish can alter rates of hepatic glucose production and peripheral uptake in response to hyperand hypoglycemia.
Persistence of Pseudorabies Virus in Feral Swine Populations

Serologic surveys for evidence of exposure to pseudorabies virus (PRV) in feral swine were conducted from November 2001 to April 2002 at 10 sites in the southeastern United States, where evidence of previous PRV exposure had been documented during 1979–89. Sera were tested in the field on the day of collection by latex agglutination. Maximum sample size per site was to be 30 animals, but sampling was discontinued before reaching this number when positive results were obtained. Positive results were obtained at all of the study sites, demonstrating long-term persistence of PRV in feral swine populations. Overall, 38 of 100 (38%) animals were positive for antibodies. Consistent results from latex agglutination tests conducted in the field and laboratory demonstrated that this test was useful as a rapid and reliable diagnostic tool when used in the field.
The economic burden of rheumatoid arthritis in a developing nation: results from a one-year prospective cohort study in Thailand.

OBJECTIVE To assess annual direct and indirect costs in a prospective cohort of patients with rheumatoid arthritis (RA) in Thailand from the societal perspective. METHODS Data on costs and intangible losses were prospectively collected at regular intervals over a one-year period from 158 RA patients who attended a major tertiary care facility in Bangkok, Thailand. Direct medical, direct nonmedical, indirect, and total costs were estimated according to patients' respective health insurance conditions and converted to 2001 US dollars using published purchasing power parity estimates. Sensitivity analyses were performed and the predictors of costs and intangible losses were investigated. RESULTS The average societal cost of RA was estimated to be 2682 US dollars, 41.4% of patients' average annual income. Average direct and indirect costs were estimated to amount to 2135 US dollars and 547 US dollars per patient per year, respectively. Seventy-three patients (46.2%) experienced at least one event of intangible losses and 46 patients (29.1%) had decreased earnings ability because of RA. Poor physical function, joint deformity, high number of disease modifying antirheumatic drugs, and steroid use contributed to higher costs and presence of intangible losses. CONCLUSION RA consumes a significant proportion of patients' annual average incomes and poses a significant economic burden to society. Since RA mainly affects a working-age population, early and timely treatment of this disease can improve both the suffering and the economic productivity of patients in Thailand.
Community detection in social networks using logic-based probabilistic programming

Community detection in complex networks has attracted a lot of attention in recent years. Communities play special roles in the structure-function relationship; therefore, detecting communities can be a way to identify substructures that could correspond to important functions. Social networks can be formalised by a generative process in which interactions between actors are generated based on some assumptions, i.e., a model with some parameters. Based on that idea, a probabilistic inference technique can be used to infer the community structure of the network. We propose a generative model to describe how network interactions are generated and show the use of a logic-based probabilistic modelling technique such as PRISM, to solve the community detection problem. The proposed model works well with directed and undirected networks, and with weighted and un-weighted networks. We use the deterministic annealing expectation maximisation algorithm in the learning process, which prove to yield a very promising result when is applied to the community detection problem.