Miracle-dz/UniFAR-FTUs huggingface dataset:
Suppressive Anti-HCV Therapy for Prevention of Donor to Recipient Transmission in Stem Cell Transplantation

A 48-yr-old man with acute myeloid leukemia (AML) required urgent allogeneic hematopoietic stem cell transplantation because of failed attempts to induce remission via chemotherapy. He had an HLA identical donor sister who was hepatitis C virus (HCV) RNA positive. In order to prevent HCV transmission to her brother, the donor was treated with weekly injections of pegylated interferon alfa-2b (150 μg subcutaneously every week) and daily ribavirin (1 g/day) for 5 wk at which time her qualitative polymerase chain reaction (PCR) was negative. Her stem cells were successfully grafted into the recipient. The recipient remained HCV PCR negative after transplant until death from relapsed AML.
ANALISIS PERAN PENGELOLA UNIT BISNIS DALAM PERENCANAAN STRATEGIS DAN UPAYA PENCAPAIAN KINERJA PERUSAHAAN (STUDI PADA INDUSTRI ENERGI LISTRIK DI JAYAPURA DAN ABEPURA)

Research this take title “Analysis Character Manager Units Business Inside Planning Strategy And Efforts Performance Corporation” (study Terapan On The Industrial Energy Electric In Jayapura and Abepura) as objek research is customer PT. PLN di Jayapura and Abepura, a number of 121 respondent.instrument analysis use in research is ‘structural equation modeling’ (SEM) where subject to change indogen laten in model this is intensity planning strategic and performance company and statistical variable eksogen laten is factor managerial, factor environmental, and factor organizational manager encode do with support software Amos 5.01. Several innovation important from research this between its : all hypothesis raise accept, which cover hypothesis EKS1 to ENDO2, EKS2 to ENDO2, EKS3 to ENDO2 and ENDO2 to ENDO1 valuable positive meaning sence factor managerial in significant,influential positive to intensity planning strategic and also factor environment also in significance influential positive to intensity planning strategic and finally intesitas planning strategic influential positive and significance to performance company. Aspect managerial important for PT.PLN to pay attention some indicators in research this so that performance take care story first, to kontruk factor managerial pursuant to koefisien estimasi the is at kontruk, hence indicator become prioritas kebijakan his start from membership manager, catch up confidence manager and last profesionalitas staff. Limitation research this happened at instant encoding for processing, especially concerning the duration time require to licensing, admission filling questioner and tabulation, remember is some reply at questioner which less consistent.
Pollen challenge study of a phototherapy device for reducing the symptoms of hay fever

ABSTRACT Objective: The objective was to investigate the effect of intranasal phototherapy delivered by a phototherapy device (allergy reliever SN-206) on symptoms of hay fever (seasonal rhinitis) due to grass pollen in adults. This registered class IIA medical device had been on sale for 15 months with no adverse effects reported but there had been no assessment of efficacy. Previous research had indicated that phototherapy could alleviate symptoms of allergic rhinitis but no double-blind, placebo-controlled trails had been done. Research design and methods: The trial is a double-blind, placebo-controlled grass pollen challenge conducted out of the pollen season, on 101 adult male and female hay fever sufferers. Subjects were assigned to placebo or active groups by stratified random sampling using responses to a baseline questionnaire. All subjects used active or placebo devices three times a day for 14 days before pollen challenge. Subjects were monitored for 2.5 h after challenge. Main outcome measures: Primary outcome measures were observed severity scores for sneezing, running eyes, running nose, and the amount of eosinophil cationic proteins (ECP) in nasal secretions. Secondary outcome measures were symptom scores by subject report (itching eyes, itching nose, itching throat, itching mouth/palate), and nasal peak inspiratory flow (PIFn) and peak expiratory flow (PEFn). Results: Significant reductions in severity of symptom scores were found for sneezing, running nose, running eyes and itchy mouth/palate (p ≤ 0.05). No significant differences were found in the results for itchy eyes, itchy nose, itchy throat, ECPs, PIFn and PEFn. No adverse events occurred. Conclusions: The results show that the device significantly reduced some hay fever symptoms. The study would have been improved if compliance was monitored electronically and if nasal congestion was monitored by report. The mode of action is unclear. The study does not consider long-term implications of the therapy.
Social network for the choice of tourist destination: attitude and behavioural intention.

Purpose – The aim of this paper is to investigate how social networks can become the main tool for achieving fast and detailed information for the choice of tourism destination, in order to deeply understand the benefits of these media for promoting tourism destinations in a global perspective, reaching a wider range of potential visitors, and developing ad hoc and marketing strategies with benefits for competitive advantage on the market.Design/methodology/approach – The research focuses on an extended Technology Acceptance Model (TAM) which also integrates the constructs e‐word‐of‐mouth communication and enjoyment. In particular, 1,397 experience users have been involved.Findings – The main findings are related to the key role of e‐word of mouth communication on both the perception of usefulness and the attitude towards the use of social network as powerful tool for the choice of tourism destinations; as well as to enjoyment which underlines the role of the fun provided by the social network and represe.
Cutting Edge: Identification of the Orphan Receptor G-Protein-Coupled Receptor 2 as CCR10, a Specific Receptor for the Chemokine ESkine1 2

A number of orphan G-protein coupled receptors (GPR) have been reported as putative chemokine receptors. One previously reported orphan receptor is an incomplete PCR clone, called GPR2. Here we report the cloning of full-length human (h)GPR2 and mouse (m)GPR2 cDNAs, and the identification of GPR2 as a receptor for a novel CC chemokine called ESkine. hGPR2 is expressed at high levels in testis and small intestine, and at lower levels in other tissues. mGPR2 was expressed at high levels in small intestine, colon, lymph nodes, and Peyer’s patches and at lower levels in thymus and spleen. Stimulation of L1.2/hGPR2 transfectants with hESkine induced their migration and resulted in intracellular calcium mobilization. These results provide evidence that GPR2 is a specific receptor for ESkine. We propose that GPR2 be renamed as CCR10. The expression pattern of mGPR2/CCR10 suggests that it may play a role in the homing/trafficking of leukocytes within intestinal and lymphoid environments.
First detection of Echinococcus multilocularis in rodent intermediate hosts in Turkey

SUMMARY Echinococcus multilocularis is the causative agent of alveolar echinococcosis (AE), a potentially fatal zoonotic disease. Large parts of Turkey are considered as endemic for E. multilocularis. The aim of this study was to determine the occurrence of metacestode of E. multilocularis in wild rodents in Erzurum, an endemic region for human AE in Turkey. During the sampling period, a total of 498 rodents were trapped in twenty counties of Erzurum Province. Suspected lesions were observed on the livers of 48 rodents, and then partial fragment of mitochondrial 12S rRNA gene was PCR-amplified. Five liver samples exhibited E. multilocularis infection. The prevalence of E. multilocularis for Microtus spp. was 1·3%. All of the infected rodents had fertile metacestodes. Infected rodents were morphologically and molecularly analysed and were confirmed to be Microtus irani by the mitochondrial cytochrome b gene sequence analysis. This is the first report of the presence of E. multilocularis in rodent intermediate hosts in Turkey. Our findings of infected M. irani with protoscoleces show that this rodent can act as suitable intermediate host for E. multilocularis’ life cycle in Turkey. However, there was a complete lack of data on the infection of carnivores from the country. An extensive survey is recommended to determine the prevalence of E. multilocularis in definitive hosts in this endemic region.
The Effects of a Service Provider's Messy Appearance on Customer Reactions

This study examines the effects of cleanliness and neatness in employee appearance on customer approach to a service interaction, identifying customer emotions and cognitions as mediators. Participants (n = 209) viewed one of six video clips, comprising two sets of three, showing a bank employee at work. The two sets were identical in all respects except for the cleanliness of employee appearance. Participants expressed more interest in approaching and in doing business with a service provider whose attire was clean and neat (as opposed to messy and dirty). Customer emotions (feelings of pleasantness) and cognitions (attributions of power) mediated the effect of cleanliness. Implications for research and management of employee appearance in customer service delivery are discussed.
On the Asymptotic Minimum Energy Required to Transport Packets in Wireless Networks

In this paper we study the asymptotic minimum energy required to transport (via multiple hops) data packets from a source to a destination. Under the assumptions that nodes are distributed according to a Poisson point process with node density n in a unit-area square and the distance between a source and a distance is at least a constant, we prove, based on percolation theory, the minimum energy required to carry a packet from a source to a destination is Θ(n(1−α)/2) with probability approaching one as the node density goes to infinity, where α is the path loss exponent. We demonstrate how to apply the derived results to obtain the bounds of the capacity of wireless networks equipped with directional antennas, the capacity of wireless networks that operate in UWB, and finally the upper bound on the lifetime of wireless sensor networks. We believe the results and the proof techniques can be applied to derive asymptotic conditions for other parameters in wireless networks, as long as the limiting factor for the parameters of interest is the energy. Finally, we carry out simulations to validate the derived results and to estimate the constant factor associated with the bounds on the minimum energy. The simulation results indicate that the constant associated with the minimum energy converges to the source-destination distance.
The Impact of Price-Based and New Product Promotions on Fast Food Restaurant Sales and Stock Prices

ABSTRACT A key tool used in demand or revenue management marketing strategies is the application of pricing tactics based on anticipated demand to enhance both customer utility and maximize firm performance (Wirtz et al., 2003). In the restaurant segment, particularly in quick-service restaurants (QSR), organizations focus on two main promotion formats to attract customers: price-based promotions and new product promotions. The purpose of this article is to explore how the number of price-based promotions and new product promotions influence firm sales growth or decline and change in stock prices. Results suggest that new product promotions can have a significant and positive effect on same store sales, whereas price-based promotions tend to results in lower same-store sales changes and changes in stock price. As an additional control for these results, the study controls for economic and seasonal conditions effects.
High frequency of Epstein–Barr virus in Chinese peripheral T‐cell lymphoma

Forty‐two cases of Chinese T‐cell lymphoma were studied for expression of Epstein–Barr virus (EBV) encoded RNA (EBER‐1) and EBV latent membrane protein‐1 (LMP‐1) using in situ hybridization and immunohistochemistry, respectively. EBV was detected in tumour cells in 24/39 peripheral T‐cell lymphomas (62%), comprising 18/27 pleomorphic, medium and large cell lymphomas (67%), 4/6 angioimmunoblastic lymphadenopathy‐like lymphomas (67%), 2/2 Lennert's lymphomas, 0/2 anaplastic large cell lymphomas, and 0/2 T‐zone lymphomas. EBV was not found in three T‐lymphoblastic lymphomas. EBV was associated with 12/24 nodal (50%) compared with 12/15 extranodal (80%) peripheral T‐cell lymphomas. In EBV positive nodal lymphomas, 9/12 cases (75%) contained less than 10% EBER positive tumour cells. In EBV positive extranodal lymphomas, 9/11 cases (82%) showed EBV gene expression in more than 50% of the tumour cells, and in five of these almost all tumour cells were positive. Lymphomas of the nasopharynx (mainly midline granuloma‐type) showed EBER‐1 expression in nearly all tumour cells. LMP‐1 was detected in 19/23 EBER positive peripheral T‐cell lymphomas (83%). Our results show that EBV is strongly associated with peripheral T‐cell lymphomas in Chinese. An important role for the virus is suggested in lymphomas of the nasopharynx. The significance of EBV in T‐cell lymphomas that contain only a minor population of virally infected tumour cells is currently unclear.
Diarrhea- and constipation-predominant IBS patients differ in postprandial autonomic and cortisol responses

OBJECTIVE:As the primary link between brain and gut, autonomic and endocrine dysfunction may play a role in the pathophysiology of the irritable bowel syndrome (IBS). The aim of this study was to assess autonomic, endocrine, and symptomatic responses to food intake in diarrhea-predominant and constipation-predominant IBS patients, compared to normals.METHODS:Twelve women with diarrhea-predominant or alternating IBS (IBS-D), 12 women with constipation predominant IBS (IBS-C), and 20 healthy women participated. GI symptoms, saliva cortisol concentration, heart rate, and heart rate variability were assessed at baseline and after a meal. Spectral analysis of heart rate variability was used as a measure of the sympathovagal regulation of the heart rate.RESULTS:Both groups of IBS patients showed a significant postprandial increase in GI symptoms. IBS-D showed a significant increase in the low frequency/high frequency band ratio and a decrease in the high frequency band power during the first postmeal period, which was significantly different, not only from controls, but also from IBS-C. IBS-D also showed a significant postprandial increase in cortisol, which was not evident in controls or IBS-C. There was a significant correlation between the vagal response and the postprandial increase in GI symptoms in IBS-D (r = 0.6, p < 0.05). CONCLUSIONS:These findings support the notion that the IBS symptom groups are characterized by different physiological responses to visceral stimuli, and point to a role of autonomic pathways in IBS symptomatology.
SAIC receiver algorithms for VAMOS downlink transmission

Voice services over Adaptive Multiuser channel in One Slot (VAMOS) performance in the presence of GMSK interferer is presented. Widely-Linear (WL) MMSE filtering is used to cancel the co-channel GMSK interferer while performing α-QPSK detection. In this paper, two ways of estimating the Sub Channel Power Imbalance Ratio (SCPIR) are discussed. Due to the colouration of the resultant impairment after filtering, WL metric is proposed which incorporates error covariance between I/Q components in the metric computation. WL RSSE is used as the equalizer. Simulation results using the proposed receiver architecture show significant performance important over conventional VAMOS receivers.
Molecular basis for oncohistone H3 recognition by SETD2 methyltransferase

Yang et al. report the crystal structures of the SETD2 catalytic domain bound to H3K36M or H3K36I peptides with SAH. In the complex structure, the catalytic SET domain adopts an open conformation, with the K36M/I peptide snuggly positioned in a newly formed substrate channel.
In-depth study of Mollivirus sibericum, a new 30,000-y-old giant virus infecting Acanthamoeba

Significance The saga of giant viruses (i.e. visible by light microscopy) started in 2003 with the discovery of Mimivirus. Two additional types of giant viruses infecting Acanthamoeba have been discovered since: the Pandoraviruses (2013) and Pithovirus sibericum (2014), the latter one revived from 30,000-y-old Siberian permafrost. We now describe Mollivirus sibericum, a fourth type of giant virus isolated from the same permafrost sample. These four types of giant virus exhibit different virion structures, sizes (0.6–1.5 µm), genome length (0.6–2.8 Mb), and replication cycles. Their origin and mode of evolution are the subject of conflicting hypotheses. The fact that two different viruses could be easily revived from prehistoric permafrost should be of concern in a context of global warming. Acanthamoeba species are infected by the largest known DNA viruses. These include icosahedral Mimiviruses, amphora-shaped Pandoraviruses, and Pithovirus sibericum, the latter one isolated from 30,000-y-old permafrost. Mollivirus sibericum, a fourth type of giant virus, was isolated from the same permafrost sample. Its approximately spherical virion (0.6-µm diameter) encloses a 651-kb GC-rich genome encoding 523 proteins of which 64% are ORFans; 16% have their closest homolog in Pandoraviruses and 10% in Acanthamoeba castellanii probably through horizontal gene transfer. The Mollivirus nucleocytoplasmic replication cycle was analyzed using a combination of “omic” approaches that revealed how the virus highjacks its host machinery to actively replicate. Surprisingly, the host’s ribosomal proteins are packaged in the virion. Metagenomic analysis of the permafrost sample uncovered the presence of both viruses, yet in very low amount. The fact that two different viruses retain their infectivity in prehistorical permafrost layers should be of concern in a context of global warming. Giant viruses’ diversity remains to be fully explored.
Diabetes mellitus and multiple therapeutic approaches of phytochemicals: Present status and future prospects

According to recent estimates, the human population worldwide appears to be in the midst of an epidemic of diabetes. Despite the great strides that have been made in the understanding and management of diabetes, the disease and disease-related complications are increasing unabated. Parallel to this, recent developments in understanding the pathophysiology of the disease process have opened up several new avenues to identify and develop novel therapies to combat the diabetic plague. Concurrently, phytochemicals identified from traditional medicinal plants are presenting an exciting opportunity for the development of new types of therapeutics. This has accelerated the global effort to harness and harvest those medicinal plants that bear substantial amount of potential phytochemicals showing multiple beneficial effects in combating diabetes and diabetes-related complications. Therefore, as the disease is progressing unabated, there is an urgent need of identifying indigenous natural resources in order to procure them, and study in detail, their potential on different newly identified targets in order to develop them as new therapeutics. This article presents an overview of multiple aspects of the pathobiology of diabetes mellitus and multimodal therapeutic effect of medicinal plants/phytochemicals and discusses the present status and future prospects of these medicines.
Lower Abdominal Bulge After Deep Inferior Epigastric Perforator Flap (DIEP) Breast Reconstruction

The etiology of lower abdominal bulge following breast reconstruction with the DIEP flap is uncertain. Most studies report an incidence that ranges from 0.7% to 5%. The purpose of this study was to review a set of factors that may predispose to a lower abdominal bulge. This was a retrospective review of 123 women who had breast reconstruction with the DIEP flap over a 4-year period. The reconstruction was unilateral in 93 women and bilateral in 30 women, totaling 153 flaps. Etiologic factors that were evaluated included patient age, diabetes mellitus, tobacco use, previous abdominal operations, unilateral or bilateral reconstruction, previous childbirth, aponeurotic plication to improve the natural abdominal contour, and use of Marlex mesh. A lower abdominal bulge occurred in 5 of the 123 women (4%), 2 following 30 bilateral reconstructions (6.6%) and 3 following 93 unilateral reconstructions (3.2%). Analysis of the factors for all women demonstrated diabetes mellitus in 1 (0.8%), tobacco use in 9 (7.3%), a prior abdominal operation in 55 (44.7%), previous childbirth in 95 (77%), aponeurotic plication in 49 (40%), and use of Marlex mesh in 4 (3.3%). Statistical analysis did not show any significant association between the explanatory factors and the occurrence of a lower abdominal bulge, except for a weak trend in women who had not been pregnant (P = 0.08). The results of this study demonstrate that the occurrence of a lower abdominal bulge following the DIEP flap is a random event that can occur in anyone. Pregnancy may confer a preventative effect as the collagen fibers strengthen to overcome the stretching forces. Techniques for prevention and treatment include intraoperative assessment of the anterior rectus sheath, use of an adjuvant material for reinforcement if unstable, and vertical plication for bulge repair.
Prediction of Birth Weight Discordance in Twin Pregnancies by Second- and Third- Trimester Ultrasound

Introduction: Our purpose was to examine whether the prenatal prediction of a critical birth weight discordance (BWD) in twin pregnancies can be improved by using either different formulae for prenatal fetal weight estimation or single biometric measurements or by assessing the intertwin discordance in the second trimester rather than shortly before birth. Material and Methods: We conducted a retrospective study involving 196 twin pregnancies with an ultrasound examination between 18 and 25 weeks of gestation and one within 14 days prior to delivery. The accuracy was assessed by comparing the prenatal intertwin discordance (PID) with the BWD. PID was estimated by 5 common fetal weight estimation formulae and by single biometric measurements prior to delivery and in the second trimester. Results: The fetal weight estimation accuracy was similar in mono- and dichorionic pregnancies and the smaller and the larger twin. PID was most accurate with the fetal weight estimation formulae prior to delivery. The second-trimester measurements resulted in an underestimation of the BWD. Detection and false-positive rates for a BWD ≧20% were about 65 and 15%. Discussion: About two thirds of the twin pregnancies with a relevant BWD can be detected prior to delivery. An optimal detection rate requires fetal weight estimation close to delivery.