Miracle-dz/UniFAR-FTUs huggingface dataset:
Immunochemical analysis of streptococcal group A, B, and C carbohydrates, with emphasis on group A

Streptococcal group A, B, and C carbohydrates were analyzed by counterimmunoelectrophoresis, immunoelectrophoresis, and inhibition of immunoprecipitation. Extracts of streptococci group A or C were shown by counterimmunoelectrophoresis to contain both anodic and cathodic migrating components. In immunoelectrophoresis, group A and C substances formed a continuous precipitation line stretching from the anode to the cathode, suggesting a heterogeneous population of molecules with immunochemical identity. This identity was confirmed by inhibition of immunoprecipitation, in which both anodic and cathodic immunoprecipitates were inhibited by the same constituent sugars: group A-anti-A was inhibited by N-acetylglucosamine, and group C-anti-C was inhibited by N-acetylgalactosamine. Extracts of group B showed only anodic migration in counterimmunoelectrophoresis and a narrow, anodic arc in immunoelectrophoresis. The group B-anti-B reaction was inhibited by rhamnose. Carbohydrates of variant strains of group A streptococci were also analyzed by the same methods. The results suggest that the heterogeneity of group A carbohydrate may have resulted from attachment of various amounts of N-acetylglucosamine to the polyrhamnose backbone.
The Hyperpolarization-Activated Cyclic Nucleotide–Gated Channels: from Biophysics to Pharmacology of a Unique Family of Ion Channels

Hyperpolarization-activated, cyclic nucleotide–gated (HCN) channels are important members of the voltage-gated pore loop channels family. They show unique features: they open at hyperpolarizing potential, carry a mixed Na/K current, and are regulated by cyclic nucleotides. Four different isoforms have been cloned (HCN1–4) that can assemble to form homo- or heterotetramers, characterized by different biophysical properties. These proteins are widely distributed throughout the body and involved in different physiologic processes, the most important being the generation of spontaneous electrical activity in the heart and the regulation of synaptic transmission in the brain. Their role in heart rate, neuronal pacemaking, dendritic integration, learning and memory, and visual and pain perceptions has been extensively studied; these channels have been found also in some peripheral tissues, where their functions still need to be fully elucidated. Genetic defects and altered expression of HCN channels are linked to several pathologies, which makes these proteins attractive targets for translational research; at the moment only one drug (ivabradine), which specifically blocks the hyperpolarization-activated current, is clinically available. This review discusses current knowledge about HCN channels, starting from their biophysical properties, origin, and developmental features, to (patho)physiologic role in different tissues and pharmacological modulation, ending with their present and future relevance as drug targets.
Re-assessing the impact of academic performance on salary level and growth: a case study

ABSTRACT This study examines the relationship between GPA and salary level and growth using a unique data set of Bryant University graduates in different stages of their careers. This study adds to a divided literature plagued with issues of heterogeneity and omitted variable biases. Results of the empirical analysis suggest that male graduates with higher GPA at graduation have experienced higher salary level and faster salary growth, while GPA has had no significant impact on women’s salary or salary growth.
Critical Evaluation of the Sediment Effect Concentrations for Polychlorinated Biphenyls

ABSTRACT In 2000, a set of sediment effect concentrations (SECs) was published for evaluating the toxicity of polychlorinated biphenyls (PCBs) in freshwater, estuarine, and marine sediments. According to the developers, these consensus-based SECs reconcile existing sediment quality guidelines (SQGs) that have been developed using various approaches, reflect causal rather than correlative effects, and can be used to determine the spatial extent of injury to sediment-dwelling organisms. In the present study, a critical evaluation of the SECs was conducted based on the original documents and databases used to develop the underlying SQGs for the SECs, as well as the original documents and data sets used to determine the predictive ability of the SECs. Results of the critical evaluation indicated that the SECs are simple mathematical constructs that share the same limitations as their underlying SQGs. The SECs are questionable “consensus” values, because many of their underlying SQGs are dissimilar, misclassified, or redundant with other SQGs. Because nearly all of the data sets included in the databases used to calculate the underlying SQGs, or to validate the SECs, were affected by elevated concentrations of multiple co-occurring chemicals, it was not possible to conclusively identify PCBs as the cause of any of the observed sediment toxicity. The SECs, and most of their underlying SQGs, are likely biased by the fact that their underlying databases are composed primarily of PCB concentrations less than 0.5 mg/kg dry weight. Comparisons between the SECs and bioaccumulation-based SQGs calculated using the equilibrium partitioning approach provide no information on whether the SECs are causally related to sediment toxicity. The primary available median lethal concentration (LC50) value for PCBs, determined using spiked-sediment toxicity tests, has limited applicability to most contaminated aquatic environments, because it was determined using an unusually low total organic carbon content. Finally, site-specific application of the SECs indicated that their predictive ability was very low, that concentration–response relationships were not found for a variety of test species and toxicity endpoints at PCB concentrations greater than the SECs, and that some of the highest survival and growth values in the toxicity tests were found at PCB concentrations considerably greater than the SECs. Based on the results of this study, we conclude that the SECs for PCBs should be used only in the screening-level evaluations that typically precede more direct assessments of sediment toxicity at individual study sites, and should not be used to predict the presence of sediment toxicity. Contrary to the conclusions of the SEC developers, the SECs do not reconcile existing SQGs, do not reflect causal effects, and should not be used to determine the spatial extent of injury to sediment-dwelling organisms.
Household Consumption and Expenditures Surveys (HCES): A Primer for Food and Nutrition Analysts in Low- and Middle-Income Countries

Background The dearth of 24-hour recall and observed-weighed food record data—what most nutritionists regard as the gold standard source of food consumption data—has long been an obstacle to evidence-based food and nutrition policy. There have been a steadily growing number of studies using household food acquisition and consumption data from a variety of multipurpose, nationally representative household surveys as a proxy measure to overcome this fundamental information gap. Objective To describe the key characteristics of these increasingly available Household Consumption and Expenditures Surveys (HCES) in order to help familiarize food and nutrition analysts with the strengths and shortcomings of these data and thus encourage their use in low- and middle-income countries; and to identify common shortcomings that can be readily addressed in the near term in a country-by-country approach, as new HCES are fielded, thereby beginning a process of improving the potential of these surveys as sources of useful data for better understanding food- and nutrition-related issues. Methods Common characteristics of key food and nutrition information that is available in HCES and some basic common steps in processing HCES data for food and nutrition analyses are described. Results The common characteristics of these surveys are documented, and their usefulness in addressing major food and nutrition issues, as well as their short-comings, is demonstrated. Conclusions Despite their limitations, the use of HCES data constitutes a generally unexploited opportunity to address the food consumption information gap by using survey data that most countries are already routinely collecting.
Investigating the impact of gender segregation within observational pretend play interaction

This paper presents an observational study conducted at the public environment investigating children's engagement with a social robot within a pretend play scenario. A pretend play system was designed in order to address the challenges of evaluating child-robot interaction by exploiting the advantages of ubiquitous robotics and ambient intelligence of multimodal, multi-sensory perception. The system performed successfully at a children's play centre where a humanoid NAO robot was able to dynamically adapt its gender by changing its gendered voice to match the gender of the child. By analyzing the free play of children, the results obtained confirm the hypothesis of gender segregation within child-robot interaction. These findings are important and ought to be considered when designing robotic applications for children in order to increase robot's perceived likeability, acceptance and engagement.
The Effect of Board Structure on Stock Picking and Market Timing Abilities of the Egyptian Mutual Fund Managers: Evidence from Financial Crisis

This paper seeks to examine the effect of mutual fund governance on stock selection and market timing abilities. This paper applies a Structural Equation Modelling technique to solve the potential endogeneity problem between internal governance measures and stock selection and market timing. The main conclusion of this paper is to provide evidence through robust statistical analysis around the usefulness of governance attributes Egyptian mutual funds stock selection and market timing abilities. Accordingly, the financial crisis demonstrates a need to modify some recommendations contained in the OECD methodology for evaluating the implementation of the OECD Principles of Corporate Governance. This paper find that board size and proportion of independent directors is negatively associated with stock selection, and proportion of directors holding zero shares is positively associated with stock selection.
Immunization Coverage Surveys and Linked Biomarker Serosurveys in Three Regions in Ethiopia

Objective Demographic and health surveys, immunization coverage surveys and administrative data often divergently estimate vaccination coverage, which hinders pinpointing districts where immunization services require strengthening. We assayed vaccination coverage in three regions in Ethiopia by coverage surveys and linked serosurveys. Methods Households with children aged 12–23 (N = 300) or 6–8 months (N = 100) in each of three districts (woredas) were randomly selected for immunization coverage surveys (inspection of vaccination cards and immunization clinic records and maternal recall) and linked serosurveys. IgG-ELISA serologic biomarkers included tetanus antitoxin ≥ 0.15 IU/ml in toddlers (receipt of tetanus toxoid) and Haemophilus influenzae type b (Hib) anti-capsular titers ≥ 1.0 mcg/ml in infants (timely receipt of Hib vaccine). Findings Coverage surveys enrolled 1,181 children across three woredas; 1,023 (87%) also enrolled in linked serosurveys. Administrative data over-estimated coverage compared to surveys, while maternal recall was unreliable. Serologic biomarkers documented a hierarchy among the districts. Biomarker measurement in infants provided insight on timeliness of vaccination not deducible from toddler results. Conclusion Neither administrative projections, vaccination card or EPI register inspections, nor parental recall, substitute for objective serological biomarker measurement. Including infants in serosurveys informs on vaccination timeliness.
Fake News: A Legal Perspective

The concept of “fake news” has garnered substantial attention in recent years, evolving from its satirical literary origins into a passionately criticized Internet phenomenon. Whether described as rumors, “counterknowledge,” misinformation, “post-truths,” “alternative facts” or just plain damned lies, these false statements of fact typically are published on Web sites and disseminated via social media for profit or social influence. While fake news publishers are regularly taken to task in the court of public opinion, we are unaware of any prior structured discussion of the unique legal issues surrounding the publication of fake news. This article evaluates examples of fake news publications to present a workable definition of “fake news” for purposes of our legal analysis. We then explore many of the legal and regulatory hurdles facing online fake news publishers. This article concludes by discussing some of the legal protections available to fake news publications and publishers of other online content.
Monetary Policy with Sectoral Trade‐Offs

We formulate a two-sector New Keynesian economy that features sectoral heterogeneity along three main dimensions: price stickiness, consumption goods durability, and the inter-sectoral trade of input materials. The combination of these factors deeply affects inter-sectoral and intra-sectoral stabilization. In this context, we examine the welfare properties of simple rules that adjust the policy rate in response to the output gap and alternative measures of final goods price inflation. Aggregating durable and non-durable goods prices depending on the relative frequency of sectoral price-setting may induce a severe bias. Due to factor demand linkages, the cost of production in one sector is influenced by price-setting in the other sector of the economy. As a result, measures of aggregate inflation that weigh sectoral price dynamics based on the relative degree of price rigidity do not allow the central bank to keep track of the effective speeds of sectoral price adjustment.
When Crisis Knocks, Call a Powerful CEO (or Not): Investigating the Contingent Link Between CEO Power and Firm Performance During Industry Turmoil

CEO power seems to be a double-edged sword: Agency-theoretic research views CEO power as ultimately detrimental to the firm, whereas the strategic leadership literature highlights the instrumental role of CEO power in getting things done. These competing perspectives motivate a lively debate in the organizational literature on the performance consequences of CEO power. To extend this line of inquiry, we examine the CEO power–firm performance relation during industry turmoil and delve into the role of three critical situational exigencies—managerial discretion, market competitiveness, and technological innovativeness. Predictions are tested on publicly traded Standard & Poor’s (S&P) 1500 firms in the United States using archival data over 20 years. Implications for further research and practice are discussed.
Behavioural state affects saccadic eye movements evoked by microstimulation of striate cortex

We examine how behavioural conditions affect the manner in which electrical stimulation of striate cortex (V1) influences the generation of saccadic eye movements. Monkeys were trained (i) to acquire a fixation spot and remain fixated for juice reward and (ii) to acquire a fixation spot and generate a saccade to a visual target for reward. Electrical stimulation was delivered at various times during the execution of these tasks. For stimulation trials, pulses were delivered at 200 Hz using a 100‐ or 200‐ms train duration. Currents as high as 1500 µA were not sufficient to evoke saccades from V1 when monkeys were actively fixating a visual target, whereas current < 100 µA was sufficient to evoke saccades when monkeys were not actively fixating. By interleaving trials in which a visual target was presented in the receptive field of stimulated neurons with nontarget stimulation trials, saccades could be evoked from V1 during the nontarget stimulation trials with currents as low as 2 µA. The position of the visual target on the interleaved trials affected the probability of saccade evocation on the nontarget stimulation trials. Additional factors that affected the evoked saccades were time of reward delivery, ratio of stimulation to nonstimulation trials, and whether stimulation was delivered on the interleaved trials in which a target was positioned in the receptive field of the stimulated neurons. We argue that the behavioural state of an animal acts on the nigra–collicular pathway to lower the current threshold for the elicitation of saccades from V1.
Apert and Crouzon Syndromes: Clinical Findings, Genes and Extracellular Matrix

Apert and Crouzon syndromes are well known craniostenosis. In the last 10 years several studies were performed to provide a better understanding of the etiology and pathogenesis of these diseases. Both have an autosomal dominant mode of transmission, and a mutation in the gene encoding for the fibroblast growth factor receptor 2 (FGFR2) is the cause in most patients. However, the fact that the same mutation can produce a wide range of phenotypic expression makes the mechanism of anomalous development more complex. The extracellular matrix (ECM) is composed of proteins, glycosaminoglycans, and cytokines that are secreted in an autocrine and paracrine manner and are able to modify the ECM. Fibroblast growth factors are complexed with heparan sulfate, a component of the ECM, before binding the FGFR2. Data exist about different expressions of cytokines and ECM macromolecule in craniostenosis-derived fibroblasts and osteoblasts. Changes in ECM composition could explain the altered osteogenic process and account for pathologic variations in cranial development in addition to the FGFR2 mutations.
Patterns of cortical thickness associated with impulse control disorders in Parkinson's disease

Previous functional neuroimaging studies in Parkinson's disease (PD) patients with impulse control disorders (ICDs) demonstrated dysfunction of the reward network, although the extent of anatomical changes is unclear. The aim of this study was to measure brain cortical thickness and subcortical volumes, and to assess their relationship with presence and severity of symptoms, in PD patients with and without ICDs. We studied 110 PD patients (N = 58 with ICDs) and 33 healthy controls (all negative for ICDs) who underwent an extensive neurological, neuropsychological, and behavioral assessment as well as structural 1.5 Tesla magnetic resonance imaging (MRI). Between‐group differences in brain cortical thickness and subcortical volumes, assessed with the FreeSurfer 5.1 tool, were analyzed. In patients with ICDs, we found significant cortical thinning in fronto‐striatal circuitry, specifically in the right superior orbitofrontal, left rostral middle frontal, bilateral caudal middle frontal region, and corpus callosum, as well as volume reduction in the right accumbens and increase in the left amygdala. Finally, we observed a positive association relationship between severity of impulsive symptoms and left rostral middle frontal, inferior parietal, and supramarginal areas. These results support the involvement of both reward and response inhibition networks in PD patients with ICDs. Moreover, their severity is associated with alterations in brain regions linked with reward and top‐down control networks. Increased understanding of the mechanisms underlying impulsive and compulsive behaviors might help improve therapeutic strategies for these important disorders. © 2015 International Parkinson and Movement Disorder Society
The Relationship between Low Family Income and Psychological Disturbance in Young Children: An Australian Longitudinal Study

Objective: This study examines the relationship between low family income (LFI) experienced at different points in time, chronic low income status and its impact on child behaviour measured at 5 years of age. Method: Longitudinal data from the Mater University Study of Pregnancy were used to measure LFI in families at three points in time (the antenatal period, 6 months post birth and at 5 years cf age). Outcome variables were three independent groups of behaviour problems labelled as externalising, social, attentional and thought (SAT) problems, and internalising problems. These groups were developed from the Child Behaviour Checklist. An analysis based on logistic regression modelling was carried out examining the relationship between LFI and a range of intermediate variables known to be associated with child behaviour problems. Results: The more often families experienced low income, the higher the rate of child behaviour problems at age 5. Low family income was still independently associated with SAT behaviour problems after controlling for smoking in the first trimester, parenting styles, maternal depression and marital dysharmony at age 5. The association between LFI and internalising and externalising behaviour problems was largely mediated by maternal depression. Conclusion: Low family income is a significant factor in the aetiology of a variety of child behaviour problems. The mechanisms involved in the link between LFI and hildhood internalising and externalising behaviours involve the exposure of the children to maternal depression. However, the relationship between LFI and SAT behaviour problems remains to be elucidated.
Factors That Influence the Decision to Perform a Karyotype in Suspected Disorders of Sex Development: Lessons from the Scottish Genital Anomaly Network Register

Background: Although a karyotype represents the first objective evidence of investigating a case of suspected disorder of sex development (DSD), the factors that influence the clinician’s decision to initiate investigations are unclear. Methods: Cases of suspected DSD in Scotland were identified through the Scottish Genital Anomaly Network (SGAN) Register. The timing as well as other factors that influence the decision to perform a karyotype were subsequently studied. Results: Out of the 572 cases on the register, 383 (67%) were classified as having a non-specific disorder of under-masculinisation. In 463 (81%) cases, the sex of rearing was male, in 71 (12%) female, and in 38 (7%) cases data regarding sex of rearing were unavailable. A karyotype was reported to have been performed in 153/572 (27%) cases. Infants in Scotland with suspected DSD are more likely to have a karyotype performed in the presence of a low external masculinisation score, bilateral impalpable testes, proximal hypospadias, or associated malformations. Discussion: These data represent the first attempt at benchmarking the decision to check a karyotype and investigate infants with suspected DSD. Whilst this decision may be related to the complexity of the genital anomaly, there are other factors that may influence this decision, and these require further exploration through more rigorous systems for data collection.
Arteries, inflammation and insulin resistance

Inflammation plays a role in all stages of atherosclerosis from the formation to the rupture of the plaque. Guided by inflammatory mediators, monocytes bind to an endothelium damaged by cardiovascular risk factors, and then migrate towards the intima where, after incorporating oxidized low-density lipoprotein particles, they are transformed into foam cells. The lipid streak forms and develops as an atherosclerotic plaque, which is susceptible to erosion and rupture. Inflammation fed by excess adipose tissue decreases insulin sensitivity, which is the central feature of the metabolic syndrome. Inflammation therefore appears to be a common factor of atherosclerosis and the metabolic syndrome. The factors triggering this inflammation have yet to be determined. One line of thought would appear to point to diet.