Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevalence of Anal High-Risk Human Papillomavirus Infections Among HIV-Positive and HIV-Negative Men Who Have Sex With Men in Nigeria

Background Prevalence estimates of anal high-risk human papillomavirus (HR-HPV) are needed in sub-Saharan Africa where HIV is endemic. This study evaluated anal HR-HPV in Nigeria among HIV-positive and HIV-negative men who have sex with men (MSM) for future immunization recommendations. Methods We conducted a cross-sectional study to compare the prevalence of anal HR-HPV infections between 64 HIV-negative and 90 HIV-positive MSM. Multivariate Poisson regression analyses were used to examine demographic and behavioral risk factors associated with any HR-HPV infections. Results The median age of the 154 participants was 25 years (interquartile range, 22–28 years; range, 16–38 years), and the median age at initiation of anal sex with another man was 16 years (interquartile range, 13–18 years; range, 7–29 years). The prevalence of anal HR-HPV was higher among HIV-positive than HIV-negative MSM (91.1% vs. 40.6%, P < 0.001). In the multivariate analysis, HIV infection (adjusted prevalence ratio [aPR], 2.02; 95% confidence interval [CI], 1.49–2.72), 10 years or more since anal sexual debut (aPR, 1.26; 95% CI, 1.07–1.49), and concurrent relationships with men (aPR, 1.32; 95% CI, 1.04–1.67) were associated with increased anal HR-HPV prevalence. Conclusions Anal HR-HPV infection is high for young Nigerian MSM, and rates are amplified in those coinfected with HIV. Providing universal coverage as well as catch-up immunization for young MSM may be an effective anal cancer prevention strategy in Nigeria.
First Molecular Detection of Babesia gibsoni in Dogs from Wuhan, China

Canine piroplasmosis is a significant disease in dogs caused by Babesia and Theileria parasites. The clinical manifestations range from mild illness to serious disease depending on the parasite species and the physical condition of the infected dog. Canine piroplasmosis has been reported to be prevalent in China. However, no molecular evidence of the disease has been reported in pet dogs from Wuhan. In this study, 118 blood samples were randomly collected from pet dogs in veterinary clinics. The blood samples were subjected to both microscopic examination and reverse line blot (RLB) hybridization assays to detect piroplasm infection. Parasites were observed in 10 blood samples via microscopic examination, whereas there were 14 Babesia gibsoni-positive RLB tests. Phylogenetic analysis was performed after the 18S rRNA and ITS gene sequences from the 14 positive samples were cloned and sequenced. The results confirmed the existence of B. gibsoni in this area. This is the first molecular report of canine babesiosis in pet dogs from Wuhan, China. Pet dogs are companion animals, and the prevalence of babesiosis will be of concern in daily life. This study will help veterinarians better understand the prevalence of canine babesiosis and provide a guide for disease control in pet dogs.
Vaccine prophylaxis of abattoir-associated Q fever: eight years' experience in Australian abattoirs

SUMMARY During the period 1981–8 a clinical trial of a Q fever vaccine (Q-vax; Commonwealth Serum Laboratories, Melbourne) has been conducted in abattoir workers and other at-risk groups in South Australia. Volunteers in four abattoirs and visitors to the abattoirs were given one subcutaneous dose of 30 μg of a formalin-inactivated, highly-purified Coxiella burnetii cells, Henzerling strain, Phase 1 antigenic state, in a volume of 0·5 ml. During the period, over 4000 subjects have been vaccinated and the programme continues in the abattoirs and related groups. ‘Common’ reactions to the vaccine comprised tenderness and erythema, rarely oedema at the inoculation site and sometimes transient headache. Two more serious ‘uncommon’ reactions, immune abscess at the inoculation site, were observed in two subjects, and two others developed small subcutaneous lumps which gradually dispersed without intervention. Protective efficacy of the vaccine appeared to be absolute and to last for 5 years at least. Eight Q fever cases were observed in vaccinees, but all were in persons vaccinated during the incubation period of a natural attack of Q fever before vaccine-induced immunity had had time (≥ 13 days after vaccination) to develop. On the other hand, 97 Q fever cases were detected in persons working in, or visiting the same abattoir environments. Assays for antibody and cellular immunity showed an 80–82% seroconversion after vaccination, mostly IgM antibody to Phase 2 antigen, in the 3 months after vaccination. This fell to about 60%, mostly IgG antibody to Phase 1 antigen, after 20 months. On the other hand, 85–95% of vaccinees developed markers of cell mediated immunity as judged by lymphoproliferative responses with C. burnetii antigens; these rates remained elevated for at least 5 years. The Q fever vaccine, unlike other killed rickettsial vaccines, has the property of stimulating long-lasting T lymphocyte memory and this may account for its unusual protective efficacy as a killed vaccine.
Time and Extent of Ciliary Response to Particles in a Non-Filtering Feeding Mechanism

Mechanisms of suspension feeding are usually described by the physics of inanimate filters. High-speed videorecordings in this study demonstrated that sea urchin larvae concentrate particles without filtration. They actively captured individual particles. At most times and places, the effective strokes of the swimming/feeding ciliary band were away from the circumoral field. Cilia of this band responded to particles by a reversal of beat that redirected the particle toward the circumoral field. A change of beat occurred along approximately 80 μm of ciliary band during particle capture. Cilia responded 0.02 to 0.06 s after the particle was within reach of effective strokes and reversed beat, usually for about 0.1 to 0.2 s. The whole event (disruption of forward beat) generally lasted between 0.13 and 0.5 s. These observations imply reversed movement of a parcel of water much larger than the included captured particle, but particles are nevertheless greatly concentrated because water is directed toward the circumoral field only when and where a particle is sensed. Thus most of the concentration of particles occurs by a temporarily and locally redirected current, without filtration, and size and quality of particles captured depends on sensory capabilities, not the mechanics of filtration.
The impact of knowledge management on job performance in higher education: The case of the University of Jordan

This is an empirical study of knowledge management performance (KMP) at a university and the purpose of this paper is to examine the relationship between knowledge management process (KMPR), KMP and job performance (JP). ,The data were collected using a questionnaire, as the instrument for the primary data collection, with total collected back responses of 207 from university lecturers who have actually participated. Structural equation modeling technique was used to fully analyze the data in order to determine what level of the relationship between knowledge management (KM) and JP existed. ,The main findings were related to confirming the two main hypotheses of the research that were related to testing if there were relationships between the KMPR (represented by seven surrogate measures, namely, knowledge identification, knowledge creation, knowledge collection, knowledge organizing, knowledge storage, knowledge dissemination and knowledge application) and KMP, as well as if the KMP was related to the JP. ,This paper focuses on investigating the actual role of KM at a university, which is assumingly a knowledge factory. Contrary to the conventional wisdom that presumes the importance of KM and specially when there is no proper KM regiment in place, the paper reports the limited influence KM has on staff JP. It is one of the few studies that fills the gap in the literature concerned with the relationship between KM and JP and perhaps the first to provide insights about the KM intricacies at a Jordanian University.
Pvlea-18, a member of a new late-embryogenesis-abundant protein family that accumulates during water stress and in the growing regions of well-irrigated bean seedlings.

Pvlea-18 is a novel stress gene whose transcript is present in the dry embryo and the endosperm from bean (Phaseolus vulgaris) seeds. It accumulates in vegetative tissues in response to water deficit and abscisic acid application (J.M. Colmenero-Flores, F. Campos, A. Garciarrubio, A.A. Covarrubias [1997] Plant Mol Biol 35: 393-405). We show that the Pvlea-18 gene encodes a 14-kD protein that accumulates during late embryogenesis. Related proteins have been detected in both monocots and dicots, indicating that PvLEA-18 is a member of a new family of LEA (Late Embryogenesis Abundant) proteins. We also show that the PvLEA-18 transcript and protein accumulate not only in different organs of the bean seedlings during water stress but also in well-irrigated seedlings. This accumulation occurs in seedling regions with more negative values of water and osmotic potentials, such as the growing region of the hypocotyl. This phenomenon has not previously been described for LEA proteins. Immunohistochemical localization showed that the PvLEA-18 protein is present in the nucleus and cytoplasm of all cell types, with a higher accumulation in the epidermis and vascular cylinder tissues, particularly in protoxylem cells and root meristematic tissues. We found a similar localization but a higher abundance in water-stressed seedlings.
Growth and sediment space occupation by seagrass Cymodocea nodosa roots

The development, growth, and space occupation by the canopy and rhizosphere of a temperate Mediterranean seagrass meadow of Cymodocea nodosa, and the possible effects of meadow seasonal development on sediment redox conditions, were examined during the 1998 growth season. The meadow supported maximum biomass of leaves and rhi- zomes during July, and maximum root biomass in August. The meadow maintained 123.6 g dry wt m -2 of leaves and 94.4 g dry wt m -2 of rhizomes (July data), and 121.2 g dry wt m -2 of roots (August data) during peak biomass. On average, the root network contained 607 m of roots m -2 , had 3.6 cm between neighbouring roots and comprised 1.7% of sediment volume. Half of the root biomass occupied the top 12.6 cm of sediment, although a few roots reached >35 cm sediment depth. The meadow developed 70, 62 and 50% of leaf, rhizome and root biomass during the growth season respectively, showing that the structure of the temperate seagrass rhizosphere is highly dynamic. C. nodosa produced leaves, rhizomes and roots at rates ranging between 1.17 and 3.98 g dry wt m -2 d -1 , 0.01 and 0.75 g dry wt m -2 d -1 , and 0.04 and 0.84 g dry wt m -2 d -1 , re- spectively. C. nodosa meadow grew on sediments where re- dox conditions during the growth season varied from -74 to 396 mV, being between 21 and 112 mV more positive than ad- jacent unvegetated sediments from July to September. The magnitude of redox potential anomaly in seagrass rhizosphere tended to be coupled to the above and belowground meadow biomass, suggesting that C. nodosa metabolism alters sedi- ment redox conditions. Structural change of seagrass mead- ows during the growth season, therefore, is expected to influ- ence benthic biogeochemical processes.
Aspects diagnostiques et thérapeutiques des déformations d’axe des membres inférieurs de l’enfant africain. Revue de 43 cas.

La description des aspects cliniques des deformations d’axe des membres inferieurs de l’enfant interesse de plus en plus, les auteurs africains. Toutefois, leur prise en charge therapeutique et notamment le volet chirurgical merite d’etre mieux codifiee. L’etude retrospective de juillet 1998 a decembre 2003, dans deux services d’Orthopedie-Traumatologie de Yaounde et Douala avait pour but de degager les aspects diagnostiques et therapeutiques de ces affections dans notre contexte. Elle a porte sur les dossiers medicaux des enfants operes pour deformations d’axe des membres inferieurs. Pour chaque patient, le diagnostic etait radio-clinique et l’essentiel du geste chirurgical represente par les osteotomies tibiales et ou femorales cuneiformes et les epiphysiodeses par agrafage. Quarante trois dossiers ont ete colliges parmi lesquels 31 filles et 12 garcons, soit un sex ratio de 0,3. L’âge moyen de nos patients etait de 9,5 ans. Trente huit pour cent et demi des patients presentaient une deviation angulaire superieure ou egale a 45°. Soixante dix osteotomies cuneiformes et 3 epiphysiodeses par agrafage etaient realisees. Le taux de complication etait de 0,6 par genou opere. La chirurgie est une methode efficace pour traiter les deformations d’axe des membres inferieurs dans leurs formes severes, frequentes en Afrique.
Percutaneous pedicle screw placement in the thoracic spine: A cadaveric study

Study Design: A cadaveric study to determine the accuracy of percutaneous screw placement in the thoracic spine using standard fluoroscopic guidance. Summary of Background Data: While use of percutaneous pedicle screws in the lumbar spine has increased rapidly, its acceptance in the thoracic spine has been slower. As indications for pedicle screw fixation increase in the thoracic spine so will the need to perform accurate and safe placement of percutaneous screws with or without image navigation. To date, no study has determined the accuracy of percutaneous thoracic pedicle screw placement without use of stereotactic imaging guidance. Materials and Methods: Eighty-six thoracic pedicle screw placements were performed in four cadaveric thoracic spines from T1 to T12. At each level, Ferguson anterior–posterior fluoroscopy was used to localize the pedicle and define the entry point. Screw placement was attempted unless the borders of the pedicle could not be delineated solely using intraoperative fluoroscopic guidance. The cadavers were assessed using pre- and postprocedural computed tomography (CT) scans as well as dissected and visually inspected in order to determine the medial breach rate. Results: Ninety pedicles were attempted and 86 screws were placed. CT analysis of screw placement accuracy revealed that only one screw (1.2%) breached the medial aspect of the pedicle by more than 2 mm. A total of four screws (4.7%) were found to have breached medially by visual inspection (three Grade 1 and one Grade 2). One (1.2%) lateral breach was greater than 2 mm and no screw violated the neural foramen. The correlation coefficient of pedicle screw violations and pedicle diameter was found to be 0.96. Conclusions: This cadaveric study shows that percutaneous pedicle screw placement can be performed in the thoracic spine without a significant increase in the pedicle breach rate as compared with standard open techniques. A small percentage (4.4%) of pedicles, especially high in the thoracic spine, may not be safely visualized.
Mandatory trans fat labeling regulations and nationwide product reformulations to reduce trans fatty acid content in foods contributed to lowered concentrations of trans fat in Canadian women's breast milk samples collected in 2009-2011.

BACKGROUND Recent efforts in Canada to reduce industrial trans fatty acids (TFAs) in foods include mandated inclusion of TFA content on food labels and recommendations by Health Canada that encourage the food industry to voluntarily limit TFA content in all vegetable oils and soft margarines and in all other prepackaged foods to <2% and <5% of total fat, respectively. OBJECTIVE To assess the impact of these efforts, we measured the concentration of TFAs in human breast milk samples. DESIGN The TFA content in 639 breast milk samples collected in 2009, 2010, and 2011 from breastfeeding mothers in 10 major cities across Canada was analyzed by gas chromatography. RESULTS The mean (±SD) TFA contents were 2.7 ± 0.9% (n = 153, range: 1.4-7.2%), 2.2 ± 0.7% (n = 309, range: 1.0-6.8%), and 1.9 ± 0.5% (n = 177, range: 0.9-3.4%) of total milk fat for samples collected in 2009, 2010, and 2011, respectively. These values are considerably lower than the value of 7.2 ± 3.0% (range: 0.1-17.2%) found previously for Canadian human milk in 1992. On the basis of a linear correlation between the percentage of TFAs in the diet and human milk fat established by Craig-Schmidt et al, and assuming that 30% of energy of a lactating mother's diet is derived from fat, we estimated from the TFA human milk fat data that TFA intake of Canadian breastfeeding mothers was 0.9%, 0.5%, and 0.3% of total energy in 2009, 2010, and 2011, respectively. These estimated values are lower than the WHO's maximum recommended intake of 1% of total energy for a healthy diet. CONCLUSIONS The results suggest that the trans fat labeling regulations introduced in 2003 and recommendations by Health Canada in 2007 instructing the food manufacturers and restaurants to limit TFAs in foods have resulted in significant reductions in TFAs in the diets of Canadian breastfeeding mothers and their breast milk.
Distribution and population structure of the anther smut Microbotryum silenes‐acaulis parasitizing an arctic–alpine plant

Cold‐adapted organisms with current arctic–alpine distributions have persisted during the last glaciation in multiple ice‐free refugia, leaving footprints in their population structure that contrast with temperate plants and animals. However, pathogens that live within hosts having arctic–alpine distributions have been little studied. Here, we therefore investigated the geographical range and population structure of a fungus parasitizing an arctic–alpine plant. A total of 1437 herbarium specimens of the plant Silene acaulis were examined, and the anther smut pathogen Microbotryum silenes‐acaulis was present throughout the host's geographical range. There was significantly greater incidence of anther smut disease in more northern latitudes and where the host locations were less dense, indicating a major influence of environmental factors and/or host demographic structure on the pathogen distribution. Genetic analyses with seven microsatellite markers on recent collections of 195 M. silenes‐acaulis individuals revealed three main genetic clusters, in North America, northern Europe and southern Europe, likely corresponding to differentiation in distinct refugia during the last glaciation. The lower genetic diversity in northern Europe indicates postglacial recolonization northwards from southern refugia. This study combining herbarium surveys and population genetics thus uniquely reveals the effects of climate and environmental factors on a plant pathogen species with an arctic–alpine distribution.
Performance on measures of 'executive function' following pediatric traumatic brain injury

Objective : To investigate the relationships among age at injury, neuroanatomic lesion location, and measures of executive function (EF) following paediatric traumatic brain injury (TBI). Methods : EF was assessed in 68 children (aged 7-15) with moderate-to-severe TBI 1 year post-injury. EF tests included: (1) Tower of Hanoi (TOH), a measure of problem solving ability, (2) Wisconsin Card Sorting Test (WCST), a measure of categorization and ability to shift cognitive strategies, (3) Letter Fluency (LF), a measure of novel lexical search and rule-governed word generation. EF variables included number of moves needed to achieve a 3-ring solution on the TOH, number of perseverative and non-perseverative errors on the WCST, and number of words generated on LF. Intellectual functioning was also assessed using the Verbal Intellectual Quotient (VIQ) from the Wechsler Intelligence Scale from Children-3rd edn (WISC-III). Data from standardized MRIs, performed at 3-months post-injury, were available for all subjects and were used to determine lesion location, lesion volumes, and total number of lesions. The relationships among EF, lesion variables (frontal lesion volume, extrafrontal lesion volume, total number of lesions) and age at injury were examined. Pre-injury special education services and attention deficit hyperactivity disorder (ADHD) were controlled for. Results : Younger age at injury was associated with more perseverative errors on the WCST and worse performance on LF. Frontal lesion volume was not predictive of performance on any measures of EF. Greater extrafrontal lesion volume and total number of lesions were predictive of worse performance on LF. When controlling for pre-injury special education placement and pre-injury ADHD, there was little change in the results. Conclusions : Younger age at injury places children at greater risk of impairment on measures of EF. Performance on measures of EF depends on brain variables other than frontal lobes including extrafrontal cortical brain areas and total number of lesions. The relationship between extrafrontal brain regions and EF suggests that domain-specific cognitive content (i.e. language or visuospatial analysis), mediated by the parietal or temporal lobes, may disrupt underlying cognitive processes necessary for successful performance on measures of EF. In addition, the association between total number of lesions and EF may be related to disconnections and disruption of frontal/subcortical systems.
Blood pressure reactivity to mental stress is attenuated following resistance exercise in older hypertensive women

Purpose This study aimed to investigate the effects of resistance exercise (RE) on autonomic control and blood pressure (BP) reactivity during mental stress (MS) in treated older hypertensive women. Methods Ten older hypertensive women (age =71.1±5.5 years; body mass index =24.2±3.9; mean BP [MBP] =85.4±3.5) underwent a protocol consisting of BP and heart rate variability (HRV) output assessments at baseline and during MS, and these measurements were taken before and 60 minutes after two bouts of RE (traditional and circuit). MS was induced through a computerized 3-minute Stroop color–word test before and 1 hour after each exercise session; BP was measured every minute during MS, and HRV was monitored as a measure of cardiac autonomic control. Results A significant effect of time on systolic BP (Δpre =17.4±12.8 versus Δpost =12.5±9.6; P=0.01), diastolic BP (Δpre =13.7±7.1 versus Δpost =8.8±4.5; P=0.01), and MBP (Δpre =14.0±7.7 versus Δpost =9.3±5.4; P<0.01) after RE was observed, with no differences between the two sessions. In addition, a significant effect of time on log-normalized low-frequency component of HRV (ms2; 5.3±0.8 pre-exercise MS versus 4.8±1.0 baseline value; P=0.023) was also observed, showing a significant change from baseline to MS before RE, but not after RE sessions. These results may be related to a lessened RE-mediated cardiac sympathetic activity during MS. Conclusion RE is an effective tool to reduce BP reactivity to MS, which could therefore be associated with an acute reduction in cardiovascular risk. This result presents relevant clinical implications, combining previous evidence that recommends this exercise modality as an important component of an exercise program designed for the older and hypertensive subjects.
Tailored versus Triple plus Bismuth or Concomitant Therapy as Initial Helicobacter pylori Treatment: A Randomized Trial

With markedly increased antibiotic resistance and unsatisfactory efficacies of common empiric eradication regimens in the mainland of China, tailored therapy may be the best choice to achieve good efficacy. This study compared the eradication rates, safety, and compliance of tailored therapy to those of triple therapy plus bismuth and concomitant therapy in the naïve patients with Helicobacter pylori infection.