Miracle-dz/UniFAR-FTUs huggingface dataset:
Risk of lung cancer in pre‐ and post‐menopausal women with ano‐genital malignancies

Women diagnosed during the period 1943–1990 and reported to the Danish Cancer Registry with invasive squamous‐cell carcinomas of the uterine cervix, vulva, vagina or anus, together with those having pre‐cancerous lesions (CIN III or carcinoma in situ) of the uterine cervix diagnosed in the period 1958–1990, were followed for the occurrence of subsequent lung cancer over 762,000 person‐years. Overall, these patients developed 2 to 2° times more lung cancers than women in the general Danish population. Women in whom cervical cancer was diagnosed recently, and before the age of 45 years, had a 4.6 times elevated risk of developing lung cancer, while young women with vulvar or vaginal cancer were at a 4.0‐fold elevated risk. Similarly, women in whom anal cancer was diagnosed before the age of 60 years were at a 3.5‐fold increased risk of developing lung cancer. The present study supports the hypothesis that smoking is involved in the aetiology of ano‐genital malignancies. The particularly high risk of developing subsequent lung cancers seen in women who were pre‐menopausal (<45 years) at the time of the ano‐genital cancer diagnosis suggests that the effect of smoking in ano‐genital carcinogenesis might be partly mediated through alterations in oestrogen metabolism. Alternatively, patients who developed their initial ano‐genital cancer at a young age might harbour some genetic susceptibility which could explain their excess lung‐cancer risk. © 1995 Wiley‐Liss, Inc.
Barber–Say syndrome in a father and daughter

We report on a father to daughter transmission of Barber–Say syndrome (BSS), a rare, congenital disorder characterized by severe generalized hypertrichosis, macrostomia, ocular telecanthus, bulbous nose and atrophic skin. These two cases further support the autosomal dominant inheritance. Both presented with the typical BSS symptoms but the phenotypic expression in the father was milder. Treatment is challenging for both patients and doctors, requiring a multidisciplinary approach. © 2010 Wiley‐Liss, Inc.
An experimental study on the shock loss at the junction of double-deck road-tunnel network

The number of cases operating urban double-deck tunnels has been increasing due to the advantages of the operation of double-deck tunnels over the world. To alleviate severe traffic congestion, a project of a double-deck road-tunnel network was planned in Seoul, Korea. The main characteristics of a planned double-deck tunnel in Korea is the presence of a network, which means the existence of various combining and dividing flows at the junction. This characteristic requires the design factors for shock loss on the ventilation system. This study examined the shock loss of combining and dividing flows and suggests a new factor for the design of a ventilation system. An experimental study was conducted with a 1:23 scaled model by referring to the design cross-section of the planned double-deck tunnel and the aspect ratio of the scaled model was 3:1. This high aspect ratio is because the height of the double-deck tunnel for a small car is lower than that of a classical tunnel. The results from this experimental study were compared with the data obtained from theoretical equations. As a result, the trend of values from this experiment showed reasonable differences: overall approximately 0.13 ~ 0.49 higher values of shock loss coefficient. The experimental result was up to three times higher than the values obtained from theoretical equations. The result showed that the shock loss coefficient from the 1:1 aspect ratio of ducts or pipes cannot be applied to that from the 3:1 aspect ratio of double-deck tunnel. Overall, the results of this study can be used to determine the shock loss on combining and separating flows at the junction in the ventilation design.
BRCA1 Regulates Gene Expression for Orderly Mitotic Progression

Germline mutations of the BRCA1 confer an increased risk for breast cancer, ovarian cancer, and several other tumor types, including prostate cancer. In sporadic (non-hereditary) breast and ovarian cancers, BRCA1 expression is frequently decreased or absent, implicating BRCA1 in the etiology of these cancers. To study the contribution of BRCA1 to sporadic cancers, we tested the effect of knocking down endogenous BRCA1 on the gene expression profiles of human prostate (DU-145) and breast (MCF-7) cancer cell lines. DNA microarray and independent confirmatory RNA analyses revealed that treatment with BRCA1 small interfering (si) RNA caused decreased expression of genes involved in cell cycle regulation and in DNA replication and repair. In particular, BRCA1-siRNA caused down-regulation of multiple genes implicated in the mitotic spindle checkpoint (eg., BUB1, BUB1B, HEC, STK6, and BIRC5), chromosome segregation (eg., ESPL1, NEK2, PTTG1, and multiple kinesins and kinesin-like proteins), centrosome function (eg., ASPM), cytokinesis (eg., PRC1, PLK, MPHOSPH1, and KNSL2), and the transition into and progression through mitosis (eg., B-type cyclins, CDC2, and CDC20). Consistent with these findings, cells treated with BRCA1-siRNA showed attenuation of the mitotic spindle checkpoint, demonstrated by a failure of cells to arrest in metaphase following treatment with nocodazole, an agent that activates the spindle checkpoint. On the other hand, BRCA1-siRNA did not attenuated the ionizing radiation-inducible G2 checkpoint or the G2 decatenation checkpoint. Finally, BRCA1 knockdown caused or promoted the accumulation of binucleated and multinucleated cells, suggesting a defect in the coordination of cytokinesis and karyokinesis; and BRCA1-siRNA caused centrosome amplification. These findings suggest that BRCA1 transcriptionally regulates gene expression for orderly mitotic progession.
COMPARISON OF CLINICAL OUTCOMES AND WOUND DYNAMICS OF SCLEROTOMY PORTS OF 20, 25, AND 23 GAUGE VITRECTOMY

Purpose: To compare the benefits, the risks and the dynamics of port closure in different gauge vitrectomy systems. Methods: Prospective, randomized, comparative study of 90 eyes undergoing 20, 23 and 25 gauge (G) vitrectomy for uncomplicated vitreous hemorrhage due to proliferative diabetic retinopathy, vasculitis, trauma, venous occlusions and others. An endoscope was used in five cases of each group to visualize the inside of sclerotomy ports. Results: Vision improved from 0.048 (3/60) to 0.206 (6/24) (p = 0.0021), from 0.069 (4/60) to 0.389 (6/18) (p < 0.0001) and from 0.055 (3/60) to 0.286 (6/24) (p = 0.0010) with 20, 23, and 25-G systems, respectively. Re-bleeds occurred in 4, 1 and 4 eyes of 20, 23 and 25-G systems respectively and post-operative retinal detachment was seen in 2 cases of 20-G system. There were no cases of post-operative hypotony or endophthalmitis seen. With 23 and 25 gauge systems, significant amount of vitreous was seen blocking the inner lip of the sclerotomy ports. Conclusion: The small gauge systems are safe and equally effective than the 20-G system for non-complicated vitreous hemorrhage cases with faster recovery and more comfort for the patient. Increased vitreous clogging with small gauge systems does not extrapolate to an increased risk of complications.
Influence of Pig Breeds on Growth Performance and Immunity During Pre-weaning Period

This study was conducted to find out the influence of pig breeds on growth performance and immunity during the pre-weaning period. The experimental designed consisted of a completely randomized design and was performed with a total of 892 piglets acquired from 105 Thai native (TN), Meishan (MS), and Large white x Landrace (LWxLR) sows. After farrowing, the piglets were weighted daily until weaning at 21 days of age and the average daily gain (ADG) was calculated. Serum samples were collected from piglets at 12 and 24 h and IgG concentrations were determined by the ELISA technique. The growth performance of LWxLR piglets measured at birth and at seven days (1.43±0.20 and 2.67±0.20, respectively) was higher (p<0.01) than TN (0.65±0.15 and 1.12±0.15, respectively) and MS (1.07±0.02 and 1.97±0.37, respectively). The growth performance of MS piglets was similar (p>0.01) to LWxLR piglets at fourteen and twenty-one days of ages. The ADG of MS and LWxLR were significantly (p<0.01) higher than TN during all lactation periods. However, the piglets of MS showed the highest ADG at fourteen days. The IgG concentrations in all breeds at 12 h were less than 24 h but the values were not considered significant (p>0.01) among the breeds. The present results indicate that different pig breeds did have an effect on growth performance and ADG. Moreover, this study showed that low birth weight of piglets resulted in low growth performance, but IgG concentrations were not found to be different among the breeds.
Atypical uterine bleeding-Histopathological audit of endometrium A study of 638 cases

Background: AUB is one of the most common problems in women of all ages especially those in the peri-menopausal age group. The abnormal bleeding can be caused by a wide variety of disorders and it is one of the commonest complaints leading to endometrial sampling. Objectives: Our study aimed at determining the types and frequencies of endometrial pathologies in patients presenting with abnormal uterine bleeding at our hospital which caters largely to women of low socioeconomic status. Material and Methods: The present study was conducted at the Hakeem Abdul Hameed Centenary Hospital, New Delhi. This was a retrospective age specific comparative analysis of 638 women presenting with abnormal uterine bleeding, who underwent endometrial sampling at our hospital. The pattern of endometrial histopathological changes were identified and classified. Results: Age of the patients ranged from 15 to 70 years, maximum patients (35.89 %) in the age group 41-50 years. The most common clinical presentation was represented by menorrhagia (41%) Various patterns on histopathology were secretory endometrium(28.99%)the commonest, followed by proliferative endometrium (24.92%). Incidence of malignancy was low in the present study. Conclusion: Endometrial curetting and biopsy is an important diagnostic procedure in evaluation of AUB. Endometrial causes of AUB are age related, therefore it is specially recommended in women of the perimenopausal age presenting with AUB, to rule out preneoplasia and malignancy.
ICE STREAMING IN THE NEWFOUNDLAND ICE CAP: IMPLICATIONS FOR THE RECONSTRUCTION OF ICE FLOW AND DRIFT PROSPECTING

A recent conceptual model of the late Wisconsinan Atlantic Canadian ice complex proposed that ice streams played a significant role in the deglaciation of the region. Within the Newfoundland portion of the ice complex, numerous topographically controlled ice streams were depicted; however, this model remains conceptual and up until recently there were few empirical tests to support this proposal. This study uses a multi-scale mapping approach to explore the potential for ice streaming in the Newfoundland Ice Cap. Initially, seven potential ice-stream signatures were identified and the geomorphology of their beds characterized. A case study of the Exploits Ice Stream is presented to confirm ice-stream operation and to highlight the detailed characteristic geomorphology of late Wisconsinan ice streaming in the Newfoundland Ice Cap. This work has implications on how ice-flow histories are reconstructed in the Newfoundland Ice Cap, highlighting the need to incorporate new evidence of ice streaming and possibly re-evaluate previous reconstructions of ice flow. Because drift prospecting relies heavily on ice-flow reconstructions to trace indicators of economic mineralization, any re-assessment of ice-flow histories requires further re-evaluation of traditional approaches to drift prospecting.
FINITE-AND INFINITE-TIME RUIN PROBABILITIES WITH GENERAL STOCHASTIC INVESTMENT RETURN PROCESSES AND BIVARIATE UPPER TAIL INDEPENDENT AND HEAVY-TAILED

In this paper we investigate the asymptotic behaviors of the finiteand infinite-time ruin probabilities for a Poisson risk model with stochastic investment returns which constitute a general adapted càdlàg process and heavy-tailed claim sizes which are bivariate upper tail independent. The results of this paper show that the asymptotic ruin probabilities are dominated by the extreme of insurance risk but not by that of investment risk. As applications of the results, we discuss four special cases when the investment returns are determined by a fractional Brownian motion, an integrated Vasicek model, an integrated Cox–Ingersoll–Ross model, and the Heston model.
Effect of some phosphorus sources , nitrogen and sulphur levels on yield , quality , sulforaphane and Vit . C content in broccoli

Two field experiments were carried out during the two seasons successive winter seasons of 2009/2010 and 2010 / 2011 at the Experimental farm of the Horticultural Research Institute at Qaha, Qalubia Governorate to study the effect of four nitrogen levels, two phosphorus sources and two sulpher levels fertilization and their interaction on vegetative growth ,yield and quality as well as chemical constitutes of broccoli plants (cv.Blestar f1). The nitrogen levels were 0, 40, 80 and 120kg N/fed. Phosphorus sources were monoammonium phosphate (MAP) and calcium super phosphate (CSP) at 60kg P2O5/fed. While, sulphur levels were 50 and 100kg S/fed. Experimental design was split split plot with three replicates. Nitrogen levels were allocated in the main plot, phosphorus sources in sub plot and sulphur levels in sub sub plot. Results showed that plant growth, yield and quality as well as chemical constituents of head were greatly affected by fertilization with nitrogen levels, phosphorus sources and sulphur levels in both seasons. In this respect, fertilization with 80kg N/fed gave the highest values of vegetative growth and yield . Moreover there was no significant differences between 80 and 120kg N/fed. Increasing nitrogen levels up to 80kg considerably improved curd height while dry matter was reduced by increasing nitrogen levels. In addition, V.C was significantly increasing by nitrogen levels up to 120kg N/fed. Also increasing levels of nitrogen application significantly increased total N, P and S in both seasons and the highest values were obtained by fertilization broccoli plant with 80kg N/fed, while the highest values of sulforaphane was significantly increased by nitrogen levels up to 40 kg N/fed. Results showed that the highest values of vegetative growth, yield and quality as well as chemical constituents of broccoli heads were found in plants supplied with Map compared with CSP as a source of phosphorus in both seasons. As regard to sulphur levels, the results show that 100kg S/fed. Significantly increased vegetative growth, yield, quality and chemical constituents in both seasons. While ,the highest values of sulforaphane was significantly affected by 100kg S/fed. The interaction between the three factors had significant effect on all studied traits. Therefore, it could be recommended for using 80kg N/fed, Map at 60kg P2O5 as a source of phosphorus and 100kg S/fed. to raise productivity and improving quality and vit.C of broccoli heads while 40kg N/fed, CSP at 60kg P2O5 as a source of phosphorus and 100kg S/fed. gave the highest values of sulforaphane which it reduce the risk of cancer.
Interleukin-17 receptor A maintains and protects the skin barrier to prevent allergic skin inflammation 1

Atopic dermatitis (AD) is a common inflammatory skin disease affecting up to 20% of children and 3% of adults worldwide and is associated with dysregulation of the skin barrier. While type 2 responses are implicated in AD, emerging evidence indicates potential role for the IL-17A signalling axis in AD pathogenesis. In this study we show that in the filaggrin mutant mouse model of spontaneous AD, IL-17RA deficiency (Il17ra-/-) resulted in severe exacerbation of skin inflammation. Interestingly, Il17ra-/mice without the filaggrin mutation also developed spontaneous progressive skin inflammation with eosinophilia, increased levels of thymic stromal lymphopoietin (TSLP) and IL-5 in the skin. Il17ra-/mice have a defective skin barrier with altered filaggrin expression. The barrier dysregulation and spontaneous skin inflammation in Il17ra-/mice was dependent on TSLP, but not the other alarmins IL-25 and IL-33. The associated skin inflammation was mediated by IL-5 expressing pathogenic effector (pe) Th2 cells and was independent of TCRγδ T cells and IL-22. An absence of IL-17RA in non-hematopoietic cells, but not in the hematopoietic cells, was required for the development of spontaneous skin inflammation. Skin microbiome dysbiosis developed in the absence of IL-17RA, with antibiotic intervention resulting in significant amelioration of skin inflammation and reductions in skin infiltrating peTh2 cells and TSLP. This study describes a previously unappreciated protective role for IL-17RA signalling in regulation of the skin barrier and maintenance of skin immune homeostasis.
Expanding public health insurance to parents: effects on children's coverage under Medicaid.

OBJECTIVE To assess whether expanding public health insurance coverage to parents leads to increases in Medicaid participation among children. DATA SOURCES/STUDY SETTING Study uses data from the 1997 and 1999 National Survey of America's Families. Insurance coverage of children eligible for Medicaid under the poverty-related expansions is analyzed. STUDY DESIGN We conduct two analyses. In the first, we examine the cross-sectional difference regarding whether Medicaid participation is higher for children eligible for Medicaid under the poverty-related expansions when states expand public health insurance programs to cover their parents. In the second, we use a difference-in-difference approach to assess whether the expansion of the Medicaid program to cover parents in Massachusetts led to an increase in Medicaid coverage among children between 1997 and 1999 relative to changes that occurred in the rest of the nation. DATA COLLECTION/EXTRACTION METHODS The analysis relies on a detailed Medicaid and SCHIP eligibility simulation model that identifies children surveyed on the NSAF who are eligible for Medicaid under the poverty-related expansions. PRINCIPAL FINDINGS Children who reside in states that expanded public health insurance programs to parents participate in Medicaid at a rate that is 20 percentage points higher than of those who live in states with no expansions. The Massachusetts expansion in coverage to parents led to a 14 percentage point increase in Medicaid coverage among children due principally to reductions in uninsurance among already eligible children. CONCLUSIONS Expanding public health insurance coverage to parents has benefits to children in the form of increased participation in Medicaid.
On Multi-Domain Network Slicing Orchestration Architecture and Federated Resource Control

A sophisticated and efficient network slicing architecture is needed to support the orchestration of network slices across multiple administrative domains. Such multi-domain architecture shall be agnostic of the underlying virtualization and network infrastructure technologies. Its objective is to extend the traditional orchestration, management and control capabilities by means of models and constructs in order to form a well-stitched composition of network slices. To facilitate such a composition of networking and compute/storage resources, this article introduces a management and orchestration architecture that incorporates Software Defined Networking (SDN) and Network Function Virtualization (NFV) components to the basic 3GPP network slice management. The proposed architecture is broadly divided into four major strata, namely the Multi-domain Service Conductor Stratum, Domain-specific Fully- Fledged Orchestration Stratum, Sub-Domain MANO and Connectivity Stratum, and Logical Multi-domain Slice Instance stratum. Each of these strata is described in detail, providing the fundamental operational specifics for instantiating and managing the resulting federated network slices.
Hardware Support for Navigating Large Digital Documents

Buxton and Myers (1986) compared a specialized document navigation device and a scrollbar. Their device tracked finger movements along two touch-sensitive areas: one for absolute movement and one for relative movement. They found that their system was faster when navigating a 5-page document. We identified finger-tracking issues with the Buxton and Myers device for larger documents (100 pages) and developed an alternative device employing a range sensor and rotary encoder to track finger movement. We ran a new experiment comparing the traditional scrollbar, the Buxton and Myers design, and our new design. Both the Buxton and Myers design and our new design were poorly received by users compared to the scrollbar. Our results indicate that in a large document, factors beyond finger tracking accuracy influence the performance of a device providing absolute movement. From these results, we identify possible improvements necessary to implement effective and practical absolute navigation devices.
Changes in numbers and habitat utilization of wintering Whooper Swans Cygnus cygnus in Sweden 1964—1977

A country-wide survey of wintering Whooper Swans Cygnus cygnus was undertaken in south Sweden in January 1995 as part of an international census of the species. The paper reports on this census and analyses Whooper Swan counts from earlier International Waterfowl Census data to elucidate changes in numbers and habitat utilization of the swans. A marked increase in the number of Whooper Swans was found between the first country-wide surveys in the early 1970s and 1995, when the winter population was estimated to be at least 8,000. The increase is not reflected in the midwinter indices, calculated from the International Waterfowl Census data, due to an increasing tendency of the Whooper Swans to feed on land in the southernmost part of the country. In January 1995, nearly 60% of the Whooper Swans in Scania were found on fields, mainly rape and winter wheat, whereas in the other parts of the country the majority of swans still utilised water areas. Earlier in the season the Whooper Swans in Scania also used sugar beet spill for feeding. The field-feeding habit started in the 1970s.
Effect of Social Network Ties in Entrepreneurial Opportunity Recognition & moderation effect of SE

Extant literature on network ties in the context of people with disabilities is scant. We believe that the contextual factors for people with disabilities vary significantly possibly due socially constructed stereotypes This paper primarily explores the role of social networks in entrepreneurial opportunity recognition by people with disabilities. Researchers have examined umpteen plausible reasons that seem to affect entrepreneurial activities, in general, and alertness to entrepreneurial opportunities, in particular, by people with disabilities. ̳Social network ties‘ are classified as mentors, informal networks, professional forums, and family & friends and their effect on entrepreneurial opportunity recognition. We used ̳mood inducement approach‘ to trigger ̳entrepreneurial ideas‘ in respondents through 30 different entrepreneurship related images. Data was collected through an online survey on from 19 disability related public forums. The present study found a support for the relationship between informal networks and mentors with opportunity. Interestingly, data reveal counter intuitive insights for family & friends, and professional forums. However, the data supported moderation effect of self-efficacy of PwDs on relationship of mentors, informal networks, professional forums, and family & friends with opportunity recognition. Therefore, the results of moderation effect of self-efficacy are more pronounced in opportunity recognition that has high self-efficacy, than in opportunity recognition with low self-efficacy. The study offers considerable implications for policy makers, academia, and also for PwDs. Finally it concludes with limitations of current study and future directions.