Miracle-dz/UniFAR-FTUs huggingface dataset:
The forgotten condyle: the appearance, morphology, and classification of occipital condyle fractures.

PURPOSE To evaluate the appearance, morphology, and treatment of occipital condyle fractures (OCF). METHODS Cases were collected by a retrospective and prospective analysis of teaching files and case logs. Patients' charts, when available, were reviewed for age, sex, mode of injury, physical examination, Glascow Coma Scale score, and associated injuries. Plain films and CT images were reviewed to determine OCF type and to assess for the presence of associated cervical spine and/or intracranial trauma. RESULTS Fifteen patients with OCF, 13 occurring in a 43-month period, were identified. Ten patients were involved in motor vehicle accidents. Severity of closed head injury and associated clinical findings were variable. Three patients had associated cervical spine fracture. According to the Anderson and Montesano classification, two patients (13%) had type I OCF, eight patients (54%) had type II OCF, and five (33%) had type III OCF. Fourteen of the fractures were identified on screening trauma head CT scans. Treatment varied according to the presence of associated injuries and stability of the cervical spine. CONCLUSIONS Although OCFs are rare, they will be encountered by most radiologists who see a significant amount of trauma. Type II OCFs were the most common fracture type in our series. Type III fractures were the second most common and potentially unstable. CT should be initiated at the level of the C-1 ring to screen for the presence of OCF in all patients who have suffered trauma.
Biological variation and quality control of plasma human immunodeficiency virus type 1 RNA quantitation by reverse transcriptase polymerase chain reaction

Quantitation of human immunodeficiency virus type 1 (HIV-1) RNA in the plasma of seropositive individuals was performed by using an external control assay with techniques to standardize and control each measurement. Rigorous study of the variability of the assay showed that the median intraassay reproducibility was log10 0.15 RNA copies per ml of plasma, while the median interassay reproducibility on replicate plasma samples was log10 0.25 copies perml. Specimen stability studies showed reproducible recovery of RNA from plasma stored at -70 degrees C for up to 12 months. In clinically stable patients who were either untreated or taking zidovudine, the average week-to-week variation in plasma RNA levels, measured in real time, was log10 0.30 RNA copies per ml. In contrast, patients either initiating or changing antiretroviral therapy showed a fall of log10 0.8 to log10 2.0 copies per ml in plasma RNA levels. Overall, 105 of 110 (96%) HIV-1-seropositive individuals with CD4 counts of 36 to 868 cells per mm3 had quantifiable HIV-1 RNA over a range of log10 2.70 to log10 6.23 RNA copies per ml, including 81% (13 of 16) of the individuals with greater than 500 CD4 cells per mm3. Accurate and reproducible quantitation of plasma viremia in real time by reverse transcriptase polymerase chain reaction, particularly in asymptomatic HIV-1-infected individuals with high CD4 counts, provides a basis for the use of this virologic measure to monitor the short- and long-term effects of early intervention therapeutic strategies on viral burden.
Senescence and age-related reproduction of female Columbian ground squirrels

Summary 1. Three hypotheses have been proposed to explain age-structured patterns of reproductive investment and somatic investment: residual reproductive value, senescence and evolutionary restraint. We evaluated these hypotheses for female Columbian ground squirrels ( Spermophilus columbianus ) by examining age-related patterns of somatic and reproductive investment. Females were designated as successful (those that weaned litters) and unsuccessful (those that did not wean litters). 2. Somatic investment varied among both successful and unsuccessful females of different ages, with yearlings having the highest investment. Considering all females, reproductive investment varied among age classes with yearlings and the oldest (6‐9year-olds) having the lowest investments. However, when only successful females were considered, reproductive investment was lowest in the yearlings and not significantly different among older females. 3. The highest proportion of successful females occurred in the middle adult age classes, while yearlings and the oldest females displayed the lowest proportion of successful females. During the breeding season, somatic investments of successful and unsuccessful females differed significantly only in the yearling age class, with unsuccessful females having the highest investment. 4. Evolutionary restraint or constraint explained patterns of reproduction in the yearling age class, where both reproductive investment and proportion of reproductive females were low. There was evidence for senescence of reproduction by some of the oldest females.
"A Sudden and Terrible Revelation": Motherhood and Infant Mortality in France, 1858-1874

In 1874, legislators in France passed a law regulating the wet-nursing industry. Citing recent medical research into the causes and social costs of high infant mortality, the law's supporters met little opposition, despite the fact that the law challenged the tradition of paternal authority and familial autonomy that had been inscribed in French law since the promulgation of the Civil Code of 1804. Extending state power into the familial realm required a concerted effort by reformers, who concentrated on two issues: maternal responsibility for newborn infants and the social costs of early death. Because working women in urban areas used wet-nurses to preserve their wage-earning capacity, reformers capitalized on widespread opposition to women's labor outside the home. The law met little opposition in part because the issues of paternal authority had already been thoroughly debated several months earlier in the child labor law of 1874.
The Association between Sleep Disturbances and Depression among Firefighters: Emotion Dysregulation as an Explanatory Factor.

STUDY OBJECTIVES To investigate emotion regulation difficulties in association with self-reported insomnia symptoms, nightmares, and depression symptoms in a sample of current and retired firefighters. METHODS A total of 880 current and retired United States firefighters completed a web-based survey of firefighter behavioral health. Self-report measures included the Center for Epidemiologic Studies Depression Scale, Insomnia Severity Index, PTSD Checklist, and Difficulties in Emotion Regulation Scale. RESULTS A notable portion of participants reported clinically significant depression symptoms (39.6%) and insomnia symptoms (52.7%), as well as nightmare problems (19.2%), each of which demonstrated a strong association with emotion regulation difficulties (rs = 0.56-0.80). Bootstrapped mediation analyses revealed that the indirect effects of overall emotion regulation difficulties were significant both for the relationship between insomnia and depression (95% CI: 0.385-0.566) and nightmares and depression (95% CI: 1.445-2.365). Limited access to emotion regulation strategies emerged as the strongest, significant indirect effect for both relationships (insomnia 95% CI: 0.136-0.335; nightmares 95% CI: 0.887-1.931). CONCLUSIONS Findings extend previous affective neuroscience research by providing evidence that insomnia and nightmares may influence depression symptoms specifically through the pathway of explicit emotion regulation difficulties. Sleep disturbances may impair the ability to access and leverage emotion regulation strategies effectively, thus conferring risk for negative affect and depression.
Sheared sheet intrusions as mechanism for lateral flank displacement on basaltic volcanoes: Applications to Réunion Island volcanoes

Field work carried out on the Piton des Neiges volcano (Réunion Island) suggests that the injection of magma along detachments could trigger flank failure by conjugate opening and shear displacement. We use 3‐D numerical models to compare the ability of purely opened sheet intrusions, sheared sheet intrusions, and normal faults to induce flank displacement on basaltic volcanoes. We assume that shear stress change on fractures results from stress anisotropy of the host rock under gravity. Exploring a large range of stress anisotropies, fracture dips, and fracture depth over length ratios, we determine that the amount of shear displacement is independent of the proximity to the ground surface. Sheared sheet intrusions are the most efficient slip medium on volcanoes. Consequently, the largest flank displacement is induced by the longest, deepest sheared intrusion dipping closest to 45° in a host rock with the highest stress anisotropy. Using our model in a forward way, we provide shear and normal displacements for buried fractures. Applying the model to a pile of sills at the Piton des Neiges volcano, we determine that the mean shear displacement caused by each intrusion was 3.7 m, leading to a total of a 180–260 m of lateral displacement for the 50 m high pile of sills. Using our model in an inverse way, we formulate a decision tree to determine some fracture characteristics and the host rock stress anisotropy from ratios of maximum surface displacements. This procedure provides a priori models, which can be used to bound the parameter space before it is explored through a formal inversion. Applying the decision tree to the 1.4 m coeruptive flank displacement recorded at Piton de la Fournaise in 2007, we find that it probably originated from a shallow eastward dipping subhorizontal normal fault.
Women's Perceptions of Their Male Batterers' Characteristics and Level of Violence

This article describes the characteristics of male perpetrators of domestic violence and their relationship to the level of violence. The data about the male partners obtained from 151 battered women were used for this analysis. Using multiple regression, demographic variables and three behavioral indicators, including use of alcohol before a violent episode, history of arrests, and the generality of violence, were examined together for their relationship with the violence scores. With the level of violence as measured by the Conflict Tactics Scale (CTS) as the dependent variable, demographic variables explained 19.1% of the variability, with the behavioral indicators accounting for an additional 4.6% of the variability. Several research and clinical implications are addressed.
Stratospheric Connection to Northern Hemisphere Wintertime Weather: Implications for Prediction

The dynamical coupling between the stratospheric and tropospheric circulations yields a statistically significant level of potential predictability for extreme cold events throughout much of the Northern Hemisphere (NH) mid‐high latitudes on both month-to-month and winter-to-winter timescales. Pronounced weakenings of the NH wintertime stratospheric polar vortex tend to be followed by episodes of anomalously low surface air temperatures and increased frequency of occurrence of extreme cold events throughout densely populated regions such as eastern North America, northern Europe, and eastern Asia that persist for ;2 months. Strengthenings of the vortex tend to be followed by surface temperature anomalies in the opposite sense. During midwinter, the quasibiennial oscillation (QBO) in the equatorial stratosphere has a similar but somewhat weaker impact on NH weather, presumably through its impact on the strength and stability of the stratospheric polar vortex; that is, the easterly phase of the QBO favors an increased incidence of extreme cold events, and vice versa. The signature of the QBO in NH wintertime temperatures is roughly comparable in amplitude to that observed in relation to
Epigenetics in the pathogenesis of systemic lupus erythematosus

Purpose of reviewThere has been a tremendous interest to understand the mechanisms that regulate gene expression in autoimmunity and their effect on disease phenotypes by exploring different epigenetic mechanisms. In this review, we will introduce lupus epigenetics through reviewing historical key findings, then we will focus on the most recent and relevant findings in this field reflecting our own and naturally biased opinion. Recent findingsIn addition to uncovering more methylation-sensitive loci in critical genes and proposing a role for these genes in the pathogenesis of lupus, there has been a great interest in high-resolution unbiased genome-wide epigenetic studies to investigate aberrant methylation and histone code patterns, the two major epigenetic markers. In recent years, we have also witnessed an increasing interest in the role of microRNAs in the pathogenesis of lupus, and as candidate molecules with intriguing therapeutic potentials. SummaryEpigenetics is an exciting field that is serving as a link, as we currently understand, between genetic susceptibility and the environment in predisposing to lupus. Certainly, epigenetic aberrancies play a fundamental role in propagation of the lupus phenotype. Whether the available epigenetic-modifying agents would be useful treating human lupus is still an open question, but is unlikely in our opinion. Indeed, gene-specific epigenetic modifiers will be a challenging and an exciting area for future research.
Substance abuse in first-episode bipolar I disorder: indications for early intervention.

OBJECTIVE This study clarified the early characteristics of substance use disorders in patients with first-episode bipolar I disorder. METHOD The authors evaluated substance use disorders, associated factors, and clinical course, prospectively, in the first 2 years of DSM-IV bipolar I disorder with standardized methods. RESULTS Baseline substance use disorder was found in 33% (37 of 112) of the patients at baseline and in 39% at 24 months. Anxiety disorders were more frequent in the patients with than without substance use disorder (30% and 13%, respectively). Associations of alcohol dependence with depressive symptoms and cannabis dependence with manic symptoms were suggested. Patients using two or more substances had worse outcomes. CONCLUSIONS Since substance use disorders were frequent from the beginning of bipolar I disorder and were associated with anxiety disorders and poor outcome, early interventions for substance use disorder and anxiety might improve later outcome.
A Case–Sibling Assessment of the Association Between Skin Pigmentation and Other Vitamin D‐related Factors and Type 1 Diabetes Mellitus

Fair skin pigmentation has been associated with a higher risk of type 1 diabetes mellitus (T1DM). The aim is to compare children with T1DM directly to a sibling in relation to their skin pigmentation in sun‐exposed and unexposed sites, past sun exposure and methylation of the VDR gene promoter. The sample consisted of children with T1DM attending a diabetes outpatient clinic and siblings (total n = 42). Cutaneous melanin density was estimated using a spectrophotometer. Parental report on past sun exposure was obtained. DNA methylation analysis of the VDR gene promoter was conducted. Matched data analysis was performed comparing each case directly to their sibling. Cases were significantly more likely to have lighter skin pigmentation at the upper arm (AOR 0.69 [95% CI: 0.52, 0.90]; P = 0.01). Low infant sun exposure was imprecisely associated with a two‐fold increase in T1DM risk (AOR 2.43 [95% CI: 0.91, 6.51]; P = 0.08 for under 1 h of winter sun exposure per leisure day). The VDR gene promoter was completely unmethylated in both cases and siblings. The previously demonstrated association between light skin pigmentation and T1DM risk was evident even in this comparison across sibling pairs. Further work on past UVR exposure and related factors such as skin pigmentation is required.
Active vitamin D and acute respiratory infections in dialysis patients.

BACKGROUND AND OBJECTIVES Vitamin D has gained attention for its pleiotropic effects in areas other than bone metabolism, and the effects of vitamin D in preventing respiratory infections have been reported as one of its immunomodulating properties. This study assessed the preventive effect of vitamin D receptor activator (VDRA) on respiratory infections in dialysis patients. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS Maintained Japanese hemodialysis patients (n = 508) were observed for 5 years, and the incidence of hospitalization during this period because of acute respiratory infection (ARI) was recorded. RESULTS Of the 508 patients, 212 had taken oral VDRA at the start of the study, whereas 296 patients had not received it. During the 5-year follow-up period, 57 patients were hospitalized because of ARIs. Kaplan-Meier analysis revealed that the incidence of hospitalization because of respiratory infection was significantly lower in patients who had been treated with VDRA compared with patients who had not (log rank test; P = 0.02). The multivariate Cox proportional hazards model demonstrated that the patients who had taken oral VDRA were at a significantly lower risk of hospitalization because of respiratory disease (hazard ratio 0.47, 95% confidence interval 0.25 to 0.90). CONCLUSIONS The findings of this study suggest that the administration of oral VDRA has a preventive effect on the incidence of ARIs in dialysis patients.
Uncoupling of cardiac and respiratory rhythm in atrial fibrillation

Abstract Rearranged origin of heart rhythm in patients with atrial fibrillation (AF) influences the regulation of the heart and consequently the respiratory rhythm, and the bidirectional interaction of these rhythms not documented. Hence, we examined coupling of the RR interval and the respiration (Resp) signal by coherence, Granger causality and the cross-sample entropy method of time series analysis in patients with AF and a healthy control group. In healthy subjects, the influence of respiration on cardiac rhythm was found as increased coherence at the breathing frequency (BF) range, significantly stronger interaction and synchrony from Resp to RR than from RR to Resp. On the contrary, in patients with AF, coherence at BF diminished, there were no causal interactions between signals in both directions, which resulted in equally great asynchrony between them. In AF, the absence of full functionality of the sinoatrial node, as an integrator of neural cardiac control, resulted in diminished vagal modulation of heart periods and consequently impaired bidirectional cardio-respiratory interaction.
Th1 and Th2 cytokines in a patient with Evans' syndrome and profound lymphopenia

A case of Evans' syndrome with IgM deficiency and lymphopenia was studied before and after splenectomy. The lymphopenia was as a result of profound reduction of CD4 and CD8 cells. Study of cytokine secretion before splenectomy revealed a spontaneous Th1‐ and Th2‐type cytokine production, and complete suppression of transforming growth factor (TGF)‐β. After splenectomy, the patient achieved clinical remission, the natural killer (NK) cell number increased and the pattern of cytokine production showed normalization of interleukin (IL)‐2, IL‐4, IL‐10, TGF‐β and abolition of interferon (IFN)‐γ production. We conclude that splenectomy had a beneficial effect owing to an increase in NK cells and an associated increase in TGF‐β production.
Electrical characterization and modeling of Phase Change Memory arrays

We present a summary of results achieved in our in-field experience on Phase Change Memory characterization which directly focuses on the reliability of arrays instead of analyses of single cells. The study of large population of cells is fundamental when new failure mechanisms have to be discovered and they may occur with small probability during common writing or reading operations.
Deep Temporal Multimodal Fusion for Medical Procedure Monitoring Using Wearable Sensors

Process monitoring and verification have a wide range of uses in the medical and healthcare fields. Currently, such tasks are often carried out by a trained specialist, which makes them expensive, inefficient, and time-consuming. Recent advances in automated video- and multimodal-data-based action and activity recognition have made it possible to reduce the extent of manual intervention required to effectively carry out process supervision tasks. In this paper, we propose algorithms for automated egocentric human action and activity recognition from multimodal data, with a target application of monitoring and assisting a user perform a multistep medical procedure. We propose a supervised deep multimodal fusion framework that relies on concurrent processing of motion data acquired with wearable sensors and video data acquired with an egocentric or body-mounted camera. We demonstrate the effectiveness of the algorithm on a public multimodal dataset and conclude that automated process monitoring via the use of multiple heterogeneous sensors is a viable alternative to its manual counterpart. Furthermore, we demonstrate that the application of previously proposed adaptive sampling schemes to the video processing branch of the multimodal framework results in significant performance improvements.
Paying for Someone Else's Mistake: The Effect of Bystander Negligence on Perpetrator Blame

The success of criminal acts can sometimes depend critically on the oversight or negligence of uninvolved bystanders (e.g., someone leaving a first-floor window open). Four studies examined how the contribution of a negligent bystander affects blame for the perpetrator of a crime. Although participants stated that discounting blame for the perpetrator was normatively inappropriate in this context, they expected that others would make this very “error. ” Instead, across all four studies, bystander negligence amplified ascriptions of perpetrator blame. This amplification occurred because the bad action of the bystander provided an implicit standard of comparison for the perpetrator's act, framing it as more blameworthy. A variety of alternative mechanisms— that bystander negligence altered perceived crime avoidability, prompted spontaneous counterfactualizing, or increased victim empathy—were tested and ruled out. Implications for legal contexts are discussed.
Skip metastases in osteosarcoma: experience of the Cooperative Osteosarcoma Study Group.

PURPOSE The outlook for patients with osteosarcoma who present with synchronous regional bone metastases (skip metastases), either in the primary bone site or transarticular, is considered to be extremely poor. This study was conducted to further investigate the prognostic implication of skip metastases in osteosarcoma. PATIENTS AND METHODS The authors retrospectively analyzed the collected data of 1,765 consecutive patients with newly diagnosed high-grade osteosarcoma of bone who were registered in the neoadjuvant Cooperative Osteosarcoma Study Group studies and identified 24 patients (1.4%) with unequivocally proven skip metastases. All 24 patients were treated by an aggressive surgical approach coupled with polychemotherapy. Demographic, diagnostic, tumor, and treatment-related variables and response and survival data were analyzed. RESULTS Skip metastases were identified preoperatively in 11 of 24 patients by bone scan, eight of 22 patients by plain x-ray, 15 of 18 patients by magnetic resonance imaging, and five of 10 patients by computed tomography. A complete surgical remission (CSR) of all clinically detectable tumor sites was achieved in 22 of 24 patients during front-line therapy. With a median follow-up time of 4.4 years (8 years for survivors) from diagnosis, 12 patients were alive, all of whom were in continuous CSR. Survival did correlate with location of skip metastases and histologic response to neoadjuvant chemotherapy. CONCLUSION Synchronous regional bone metastases are rare in osteosarcoma, and preoperative detection relies on appropriate diagnostic imaging. Aggressive multimodal therapy holds the promise to achieve prolonged survival, especially in patients in whom these metastases occur within the same bone as the primary lesion and whose tumors respond well to chemotherapy.