Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessing the Potential of Metaphoricity of verbs using corpus data

The paper investigates the relation between metaphoricity and distributional characteristics of verbs, introducing POM, a corpus-derived index that can be used to define the upper bound of metaphoricity of any expression in which a given verb occurs. The work moves from the observation that while some verbs can be used to create highly metaphoric expressions, others can not. We conjecture that this fact is related to the number of contexts in which a verb occurs and to the frequency of each context. This intuition is modelled by introducing a method in which each context of a verb in a corpus is assigned a vector representation, and a clustering algorithm is employed to identify similar contexts. Eventually, the Standard Deviation of the relative frequency values of the clusters is computed and taken as the POM of the target verb. We tested POM in two experimental settings obtaining values of accuracy of 84% and 92%. Since we are convinced, along with (Shutoff, 2015), that metaphor detection systems should be concerned only with the identification of highly metaphoric expressions, we believe that POM could be profitably employed by these systems to a priori exclude expressions that, due to the verb they include, can only have low degrees of metaphoricity
Title Biodegradable CpG DNA hydrogels for sustained delivery of doxorubicin and immunostimulatory signals in tumor-bearing mice

Immunostimulatory CpG DNA was self-assembled to form DNA hydrogels for use as a sustained delivery system for both intercalated doxorubicin (DXR) and immunostimulatory CpG motifs for cancer treatment. X-shaped DNA (X-DNA) was designed as a building unit, and underwent ligation to form DNA hydrogels. Two types of X-DNA were constructed using four oligodeoxynucleotides each, one containing six potent CpG motifs (CpG X-DNA) and the other with none (CpG-free X-DNA). CpG X-DNA was more effective than its components or the CpG-free counterpart in terms of the production of tumor necrosis factor- from murine macrophage-like RAW264.7 cells, as well as maturation of the murine dendritic DC2.4 cells. The cytotoxic effects of X-DNA, DXR and their complexes were examined in a co-culture system of colon26/Luc cells, a murine adenocarcinoma clone stably expressing firefly luciferase, and RAW264.7 cells. DXR/CpG X-DNA showed the highest ability to inhibit the proliferation of colon26/Luc cells. DXR was slowly released from CpG DNA hydrogels. Injections of DXR/CpG DNA hydrogels into a subcutaneous colon26 tumor effectively inhibited tumor growth. These results show that CpG DNA hydrogels are an effective sustained system for delivery of immunostimulatory signals to TLR9-positive immune cells and DXR to cancer cells.
Disorder Effects on the Intrinsic Nonlinear Current Density in ${\rm YBa}_{2}{\rm Cu}_{3}{\rm O}_{7-\delta}$

We present harmonic generation measurements of the intrinsic nonlinear current density j<sub>2</sub> of YBa<sub>2</sub>Cu<sub>3</sub>O<sub>7-delta</sub> (YBCO) films at temperatures close the T<sub>c</sub>. Experiments on a range of different quality samples allow us to extract the dependence of j<sub>2</sub> on the penetration depth of the superconductor. In order to model these results, we calculate the intrinsic nonlinear current response of d<sub>x</sub> <sup>2</sup> <sub>-y</sub> <sup>2</sup>-wave superconductors in the Meissner regime in the presence of nonmagnetic impurities within the self-consistent T-matrix approximation.
Feeding and Life History of Spodoptera exigua (Lepidoptera: Noctuidae) on Different Host Plants

Abstract Consumption rates, development times, and life table parameters of the beet armyworm, Spodoptera exigua (Hübner), were determined on five host plants: cabbage, Brassica oleracea capitata L; cotton, Gossypium hirsutum L. ; bell pepper, Capsicum annuum L. ; pigweed, Amaranthus retroflexus L. ; and sunflower, Helianthus annuus L. Mean total leaf weight consumed by larvae was highest in cabbage (2.7 g) and lowest in pigweed (1.6 g). The feeding index (pupal weight divided by total weight of leaf tissue consumed) was highest on pigweed, followed by cotton, pepper, sunflower, and cabbage. On all host plants, significant relationships were found between amount of leaf tissue consumed and resulting pupal weight. Likewise, significant relationships were found between pupal weight and subsequent adult fecundity on all host plants. The highest percentage of female progeny was recorded in S. exigua reared on pigweed (62.2%) and the lowest for larvae reared on cabbage (43.6%). Duration of the larval stage was shortest on pigweed (12.4 d) and longest on pepper (18.0 d). Larval survival was highest on pigweed (94.4%) and lowest on cabbage (67.1%). Three key statistics were used to assess performance of S. exigua on the different host plants: 1) feeding index, 2) intrinsic rate of increase, r; and 3) growth index (percentage immature survival divided by immature development time). Using these measures, S. exigua performance was best on pigweed, worst on cabbage, and intermediate on cotton, pepper, and sunflower. We discuss the implications of these findings for control of S. exigua.
Toxicokinetic of flumethrin in rabbits

Abstract In this study, the toxicokinetic of flumethrin after single oral and intravenous applications were studied. For this aim, 14 male New Zealand rabbits were used. The animals were divided into two groups of seven each. While 10 mg/kg.bw of flumethrin was intravenously injected into the first group, the same dose was administered orally with the second group. Serial blood samples were also collected at certain periods. Flumethrin concentrations were measured using a gas chromatography with a micro electron capture detector. The serum flumethrin concentration-time curve was determined to fit a two-compartment open model. Among the parameters calculated following intravenous application of flumethrin, the half-life at β phase (t1/2β), mean residence time (MRT) and area under the concentration time curve in 0–∞ (AUC0→∞) values were respectively found to be 34.0 ± 4.2 h, 48.0 ± 5.8 h and 36.1 ± 5.3. On the other hand, the maximal concentration in serum (Cmax), time needed to reach Cmax (tmax), t1/2β, MRT and AUC0→∞ values of flumethrin after oral administration were determined to be 0.54 ± 0.09 μg/ml, 5.42 ± 0.97 h, 43.3 ± 8.6 h, 59.7 ± 10.5 h and 22.0 ± 2.0 mg.h/L, respectively. The bioavailability of flumethrin was found to be 60.9%. In conclusion, these results were considered to be important in terms of the toxication risk of flumethrin and its safe use.
Expression of RCAS1 in esophageal squamous cell carcinoma is associated with a poor prognosis

Receptor‐binding cancer antigen expressed on SiSO cells (RCAS1) has been reported to act as a ligand for a receptor present on normal peripheral lymphocytes and to induce apoptotic cell death. We aimed to elucidate the significance of RCAS1 expression in human esophageal squamous cell carcinomas (ESCC).
Role of nitric oxide in renal function in rats with short and prolonged periods of streptozotocin‐induced diabetes

Objective: Nitric oxide (NO) has been proposed to play a significant role in renal function. In addition, NO production has been found to increase in diabetes mellitus. The present study aimed to clarify the mechanism responsible for NO action in renal function in rats with short (10 days) or prolonged periods (8 weeks) of diabetic induction.
Olmos-Liceaga Obstacles as Switches between Different Cardiac Arrhythmias

Ventricular fibrillation is a very important health problem as is the cause of most of the sudden deaths in the world. Waves of electrical activity are sent by the SA node, propagate through the cardiac tissue and activate the mechanisms of cell contraction, and therefore are responsible to pump blood to the body harmonically. A spiral wave is an abnormal auto sustainable wave that is responsible of certain types of arrhythmias. When these waves break up, give rise to the fibrillation regime, in which there is a complete loss in the coordination of the contraction of the heart muscle. Interaction of spiral waves and obstacles is also of great importance as it is believed that the attachment of a spiral wave to an obstacle can provide with a transition of two different arrhythmias. An obstacle can be partially excitable or non excitable. In this talk, we present a numerical study of the interaction of meandering spiral waves with partially and non excitable obstacles and focus on the problem where the obstacle plays a fundamental role in the switch between different spiral regimes, which represent different arrhythmic regimes. Particularly, we study the phenomenon of destabilization of spiral waves due to the presence of obstacles, a phenomenon not completely understood (This work will appear as a Chapter in a Book named Cardiac Arrhytmias by INTECH under the name ”Spiral Waves, Obstacles and Cardiac Arrhythmias”, ISBN 979-953-307-050-5.). Keywords—Arrhythmias, Cardiac tissue, Obstacles, Spiral waves
Local and Relational Aspects of Face Distinctiveness

Distinctiveness contributes strongly to the recognition and rejection of faces in memory tasks. In four experiments we examine the role played by local and relational information in the distinctiveness of upright and inverted faces. In all experiments subjects saw one of three versions of a face: original faces, which had been rated as average in distinctiveness in a previous study (Hancock, Burton, & Bruce, 1996), a more distinctive version in which local features had been changed (D-local), and a more distinctive version in which relational features had been changed (D-rel). An increase in distinctiveness was found for D-local and D-rel faces in Experiment 1 (complete faces) and 3 and 4 (face internals only) when the faces had to be rated in upright presentation, but the distinctiveness of the D-rel faces was reduced much more than that of the D-local versions when the ratings were given to the faces presented upside-down (Experiments 1 and 3). Recognition performance showed a similar pattern: presented upright, both D-local and D-rel revealed higher performance compared to the originals, but in upside-down presentation the D-local versions showed a much stronger distinctiveness advantage. When only internal features of faces were used (Experiments 3 and 4), the D-rel faces lost their advantage over the Original versions in inverted presentation. The results suggest that at least two dimensions of facial information contribute to a face's apparent distinctiveness, but that these sources of information are differentially affected by turning the face upside-down. These findings are in accordance with a face processing model in which face inversion effects occur because a specific type of information processing is disrupted, rather than because of a general disruption of performance.
Expression of tenascin in human cervical cancer--association of tenascin expression with clinicopathological parameters.

OBJECTIVE Tenascin is an extracellular matrix glycoprotein, relevant for embryonal and fetal development, which is reexpressed in the stroma of benign and malignant tumors. Little is known about the molecular interaction of tenascin during neoplastic transformation and tumor progression in cervical cancer. METHOD We studied the expression of tenascin in normal tissue of the cervix uteri, cervical carcinoma in situ, and invasive cervical carcinoma in paraffin sections by immunohistochemistry using a monoclonal antibody. Tenascin immunoreactivity was compared with various prognostic parameters. RESULTS In normal cervical tissue (n = 5) and in cervical carcinoma in situ (n = 10) only vessel walls showed a weak tenascin cross-reactivity, whereas tenascin was not expressed in the epithelial layer or the underlying connective tissue. In invasive cervical carcinoma (n = 89) tenascin expression was markedly increased. In 84% (n = 75) of the cases examined a strong tenascin immunoreactivity was noted around and within the tumor cell nests. Sixteen percent (n = 14) of infiltrating cervical carcinomas showed no tenascin immunoreactivity. A definite correlation was found between weak or no tenascin expression and slight desmoplastic mesenchymal reactivity (n = 42/91%, P < 0.001), lymphatic space invasion (n = 54/81%, P < 0.001), and lymph node metastases (n = 30/77%, P < 0.05). Tenascin-positive patients had a significantly better prognosis than tenascin-negative patients (mean survival time of 56.5 +/- 4.1 months versus 31.9 +/- 5.6 months, P < 0.05). CONCLUSION Based on these findings we discuss that the appearance of tenascin is an indicator of an adequate biological defense in cervical cancer patients. The tenascin staining may therefore be useful for detecting a subgroup of invasive cancer patients missing tenascin reactivity with alterations of stromal defense and a poorer prognosis.
Is walking barefoot a risk factor for diabetic foot disease in developing countries?

INTRODUCTION Walking barefoot is common in poorer developing countries which have large rural populations. Although high rates of foot injury could be expected among those who walk barefoot, walking barefoot as a risk factor for diabetic foot disease is rarely documented in the literature. METHODS Two preliminary clinical studies were undertaken to investigate whether there is a causal link between walking barefoot and diabetic foot ulcers. The first study investigated whether being barefoot was a factor in initiating foot ulceration. In the second study, 204 consecutive diabetic outpatients were studied to further investigate the association between diabetic foot disease and walking barefoot. RESULTS In the first study, of the 75 consecutive diabetics admitted for foot ulceration of less than 4 weeks, 32 (42.4%) had foot ulcers resulting from injuries by sharp or hard objects. Of those injured, 27 (84%) were barefoot at the time of the injury. This suggested that walking barefoot is a risk factor for foot ulcers, and that using footwear has the potential to prevent foot ulcers. In the second study, the relative risk of foot ulcers among barefoot diabetics was 2.21 (95% CI 1.55 to 3.14) compared with those using some form of footwear. A history of foot ulcers was more frequent in the group who wore footwear less than 10 hours per day, compared with those who used footwear more than 10 hours. The prevalence of web space and nail infections was also higher in the group who wore footwear less than 10 hours per day, compared with those who used footwear for more than 10 hours. CONCLUSION The data suggest that walking barefoot is a risk factor for diabetic foot disease. Thus, public health messages in developing countries with large rural populations who walk barefoot should strongly advise diabetics to use footwear for a greater part of the day. This may be overlook in literature originating from affluent countries where footwear use is the norm. Further studies are indicated to investigate potential associations between walking barefoot, rurality and cultural factors.
Personality, Cognitive Adaptation, and Marital Satisfaction as Predictors of Well-Being among Older Married Adults

ABSTRACT The current study examines constructs that contribute to the well-being of an international sample of older married adults. A convenience sample of 208 participants was recruited through an Internet site as well as more traditional means such as newspaper advertisements and contact with community groups. The resulting structural equation model provides further support for the revised theory of cognitive adaptation. Within this model, the direct and indirect contributions of personality, marital satisfaction, and cognitive adaptation are examined in relation to well-being. Contrary to previous findings, personality appears to have an indirect effect upon both marital satisfaction and well-being. Cognitive adaptation, in contrast, has both a direct and indirect effect upon the well-being of older adults. Limitations of use of the Internet as a vehicle for data collection are considered as well as directions for future study. RÉSUMÉ La présente étude porte sur les divers concepts qui ont contribué au bien-être d'un échantillon international de personnes mariées du troisième âge. Un échantillon de commodité constitué de 208 participants a été recruté au moyen d'un site Internet ainsi que de méthodes plus traditionnelles comme des annonces dans les journaux et des contacts avec des groupes communautaires. Le modèle d'équation structurelle obtenu tend à appuyer davantage la version révisée de la théorie de l'adaptation cognitive. Dans le cadre de ce modèle, la contribution directe et indirecte de la personnalité, de la satisfaction à l'égard du mariage et de l'adaptation cognitive est étudiée en regard du bien-être. Contrairement aux résultats de recherches antérieures, la personnalité semble avoir un effet indirect sur la satisfaction à l'égard du mariage et sur le bien-être. L'adaptation cognitive, par contre, a un effet direct et indirect sur le bien-être des personnes âgées. L'étude aborde les contraintes liées à l'utilisation d'Internet, à titre de moyen pour la cueillette de données, et fournit des orientations pour des recherches ultérieures.
Evaluation of heart condition based on ballistocardiogram classification using compactly supported wavelet transforms and neural networks

One of the most usual causes of death of the human are among heart diseases. Several electronic devices have been developed to assist clinicians in monitoring and diagnosing heart diseases. Ballistocardiography (BCG) was one of popular methods before the 1970s but after that other methods have replaced it, partly because the devices were difficult to construct. Recently developed sensors offer new unobtrusive possibilities to evaluate the condition of the patient's heart even at home without attaching electrodes to the patient. Thus, it is suitable for evaluation of the heart condition in any place because of being user-friendly method. In this study, we applied compactly supported (Daubechies as well as biorthogonal) wavelet transforms in a comparison way to extract essential features of the BCG signal and neural networks to classify the BCG. Initial tests with BCG from six subjects indicate that the method can classify the subjects to three classes with a high accuracy. The method is almost insensitive to latency and non-linear disturbance. Moreover, the wavelet transform requires no prior knowledge of the statistical distribution of data samples and the computational complexity and training time are reduced
Problem drinking and intimate partner violence.

OBJECTIVE This study examined the role of problem drinking in intimate partner violence (IPV) perpetration and victimization for men and women. We assessed (1) whether the relationship between problem drinking and IPV was spurious and (2) if relationship dissatisfaction and partner drinking mediated the effects of problem drinking on IPV. METHOD Five waves of longitudinal data from a nonclinical sample (N = 725; 400 women), aged 12 through 31 years, were analyzed to determine the effects of problem drinking on IPV after controlling for eight common risk factors. Regression analyses were conducted to determine whether relationship dissatisfaction and partner drinking patterns mediated the effects of problem drinking on IPV after controlling for these same risk factors. RESULTS With controls, problem drinking significantly predicted perpetration and victimization for men and women. Partner drinking was not related to perpetration or victimization for men. For women, partner drinking was strongly related to perpetration and victimization. It fully mediated the effects of problem drinking on perpetration, but did not mediate these effects on victimization. Relationship dissatisfaction fully mediated the effects of problem drinking on male and female perpetration and partially mediated the effects on male victimization. Relationship dissatisfaction did not mediate the effects of problem drinking on female victimization. CONCLUSIONS The relationship between problem drinking and IPV was not spurious for men or women. Heavier drinking by partners put women at greater risk for perpetration and victimization and mediated the effects of their own problem drinking on perpetration. Programs that prevent and treat problem drinking among young men should have a beneficial impact on reducing IPV.
BINOCh: binding inference from nucleosome occupancy changes

UNLABELLED Transcription factor binding events are frequently associated with a pattern of nucleosome occupancy changes in which nucleosomes flanking the binding site increase in occupancy, while those in the vicinity of the binding site itself are displaced. Genome-wide information on enhancer proximal nucleosome occupancy can be readily acquired using ChIP-seq targeting enhancer-related histone modifications such as H3K4me2. Here, we present a software package, BINOCh that allows biologists to use such data to infer the identity of key transcription factors that regulate the response of a cell to a stimulus or determine a program of differentiation. AVAILABILITY The BINOCh open source Python package is freely available at http://liulab.dfci. harvard.edu/BINOCh under the FreeBSD license.
Liquid chromatography/electrospray tandem mass spectrometry characterization of styrene metabolism in man and in rat.

Liquid chromatography with electrospray tandem mass spectrometry was used to characterize the metabolism of styrene in man and in rat. To improve identification and characterization of minor styrene metabolites, rats were co-exposed to styrene and styrene-d(8). In addition to the main styrene metabolites, mandelic acid and phenylglyoxylic acid, and specific mercapturic acids, phenylhydroxyethylmercapturic acids (PHEMAs), other minor metabolites, including phenylglycine, N-acetyl-S-(phenacyl)cysteine, 4-vinylphenol and styreneglycol conjugates (glucuronides and sulfates) were identified and determined both in human and rat urine. Phenylglycine and N-acetyl-S-(phenacyl)cysteine have been hypothesized to occur, but never detected in human or rat urine after styrene exposure. 4-Vinylphenol and styrene glycol had already been recognized as styrene metabolites, but never determined as intact glucuronide and sulfate conjugates. Failure to identify 1- and 2-phenylethanol conjugates suggests that phenylethanol might be an intermediate metabolite, but it is not a conjugated catabolite. A method for the simultaneous determination of mandelic acid, phenylglyoxylic acid, phenyglycine and the four PHEMA diastereoisomers has been developed and validated. For those glucuronide and sulfate conjugates whose standards are not commercially available, a method for semiquantitative analysis, based on the use of structurally similar compounds as standards, has been developed. This approach was found to be valid for the determination of 4-vinylphenol glucuronide and 4-vinylphenol sulfate.