Miracle-dz/UniFAR-FTUs huggingface dataset:
A mug's game? Solving the problem of induction with metaphysical presuppositions

A Mug's Game? Solving the Problem of Induction with Metaphysical Presuppositions Nicholas Maxwell Emeritus Reader in Philosophy of Science at University College London Email: nicholas.maxwell@ucl.ac. uk Website: www.nick-maxwell.demon. co.uk Abstract This paper argues that a view of science, expounded and defended elsewhere, solves the problem of induction. The view holds that we need to see science as accepting a hierarchy of metaphysical theses concerning the comprehensibility and knowability of the universe, these theses asserting less and less as we go up the hierarchy. It may seem that this view must suffer from vicious circularity, in so far as accepting physical theories is justified by an appeal to metaphysical theses in turn justified by the success of science. But this is rebutted. A thesis high up in the hierarchy asserts that the universe is such that the element of circularity, just indicated, is legitimate and justified, and not vicious. Acceptance of the thesis is in turn justified without appeal to the success of science. It may seem that the practical problem of induction can only be solved along these lines if there is a justification of the truth of the metaphysical theses in question. It is argued that this demand must be rejected as it stems from an irrational conception of science.
A Two-Layer Deep Learning Method for Android Malware Detection Using Network Traffic

Because of the characteristic of openness and flexibility, Android has become the most popular mobile platform. However, it has also become the most targeted system by mobile malware. It is necessary for the users to have a fast and reliable detection method. In this paper, a two-layer method is proposed to detect malware in Android APPs. The first layer is permission, intent and component information based static malware detection model. It combines the static features with fully connected neural network to detect the malware and test its effectiveness through experiment, the detection rate of the first layer is 95.22%. Then the result (benign APPs from the first layer) is input into the second layer. In the second layer, a new method CACNN which cascades CNN and AutoEncoder, is used to detect malware through network traffic features of APPs. The detection rate of the second layer is 99.3% in binary classification (2-classifier). Moreover, the new two-layer model can also detect malware by its category (4-classifier) and malicious family (40-classifier). The detection rates are 98.2% and 71.48% respectively. The experimental results show that our two-layer method not only can achieve semi-supervise learning, but also can effectively improve the detection rate of malicious Android APPs.
Familial primary lateral sclerosis or dementia associated with Arg573Gly TBK1 mutation

Primary lateral sclerosis (PLS) is a rare variant of motor neuron disease (MND) characterised by selective upper motor neuron features whose causes and pathogenic mechanisms remain largely unknown. While some familial cases of childhood to young–adult onset with recessive transmission have been reported in association with mutations in the Alsin, SPG11 and SPG7 genes,1 most adult cases occur sporadically. Recently, Tank-binding kinase 1 ( TBK1 ) mutations have been identified in 1.9% of frontotemporal dementia(FTD) and/or Amyotrophic lateral sclerosis (ALS) cohorts.2 However, pathogenicity of many TBK1 missense mutations is difficult to establish in the absence of cosegregation data. A screening for TBK1 mutations carried out by the European Early-Onset Dementia (EU EOD) Consortium in a large series of FTD/ALS cases found one carrier of the Arg573Gly mutation.3 The index case belonged to a Spanish family with autosomal dominant disease manifesting in the sixth decade as either dementia or PLS, and in whom we were able to demonstrate cosegregation. TBK1 screening included 2553 individuals with FTD and/or ALS and 2288 European controls, including 549 of Spanish origin, and was conducted by the EU EOD Consortium as previously described.3 The family with the Arg573Gly mutation comprises an affected father and nine offspring, of whom five have been affected by either dementia or PLS (figure 1). Four affected and one healthy sibling have been clinically and genetically examined. Retrospective information was obtained regarding the disease process in cases I.1 and II. 2. Figure 1 Top: family tree. Bottom: sequence of recruitment of clinical features in the affected family members. Amnestic dementia refers to …
Ultrasonographic findings in cows with left displacement of the abomasum

Forty-eight cows with left displacement of the abomasum (LDA) and three clinically healthy control cows were examined ultrasonographically from the 11th and 12th intercostal spaces on the left side. In the controls, the rumen was immediately adjacent to the left abdominal wall, whereas in the cows with LDA the rumen was generally immediately adjacent to the left abdominal wall ventrally, but displaced by the abomasum more dorsally. The ultrasonographic findings were generally consistent in the cows with LDA. The ingesta that were visualised ventrally in the abomasum appeared echogenic to hypoechogenic and, in a few cows, the abomasal folds were visible as elongated, echogenic, sickle-shaped structures. The dorsal abomasal gas cap was characterised by reverberation artifacts from the abomasal surface.
Membrane fluidity is involved in the regulation of heat stress induced secondary metabolism in Ganoderma lucidum

Ganoderma lucidum has become a potential model system for evaluating how environmental factors regulate the secondary metabolism of basidiomycetes. Heat stress (HS) is one of the most important environmental factors. It was previously reported that HS could induce the biosynthesis of ganoderic acids (GA). In this study, we found that HS increased GA biosynthesis and also significantly increased cell membrane fluidity. Furthermore, our results showed that addition of the membrane rigidifier dimethylsulfoxide (DMSO) could revert the increased GA biosynthesis elicited by HS. These results indicate that an increase in membrane fluidity is associated with HS-induced GA biosynthesis. Further evidence showed that the GA content was decreased in D9des-silenced strains and could be reverted to WT levels by addition of the membrane fluidizer benzyl alcohol (BA). In contrast, GA content was increased in D9des-overexpression strains and could be reverted to WT levels by the addition of DMSO. Furthermore, both membrane fluidity and GA biosynthesis induced by HS could be reverted by DMSO in WT and D9des-silenced strains. To the best of our knowledge, this is the first report demonstrating that membrane fluidity is involved in the regulation of heat stress induced secondary metabolism in filamentous fungi.
Metagenome Sequencing of the Greater Kudu (Tragelaphus strepsiceros) Rumen Microbiome

ABSTRACT Ruminant herbivores utilize a symbiotic relationship with microorganisms in their rumen to exploit fibrous foods for nutrition. We report the metagenome sequences of the greater kudu (Tragelaphus strepsiceros) rumen digesta, revealing a diverse community of microbes and some novel hydrolytic enzymes.
Protein aggregation determinants from a simplified model: Cooperative folders resist aggregation

Two‐chain aggregation simulations using minimalist models of proteins G, L, and mutants were used to investigate the fundamentals of protein aggregation. Mutations were selected to break up repeats of hydrophobic beads in the sequence while maintaining native topology and folding ability. Data are collected under conditions in which all chain types have similar folded populations and after equilibrating the separated chains to minimize competition between folding and aggregation. Folding cooperativity stands out as the best single‐chain determinant under these conditions and for these simple models. It can be experimentally measured by the width of the unfolding transition during thermal denaturation and loosely related to population of intermediate‐like states during folding. Additional measures of cooperativity and other properties such as radius of gyration fluctuations and patterning of hydrophobic residues are also examined. Initial contact system states with transition‐state characteristics can be identified and are more expanded than average initial contact states. Two‐chain minimalist model aggregates are considerably less structured than their native states and have minimal domain‐swapping features.
Information Rx: Evaluation of a new informatics tool for physicians, patients, and libraries

This paper reports selected results from two comprehensive evaluation studies of the Information Prescription (or "Information Rx") Program implementation conducted from 2002-05 by the American College of Physicians Foundation (ACPF) and the U.S. National Library of Medicine (NLM). In this Program physicians are provided with Information Prescription pads, analogous to pads used to prescribe medications, that are used to direct patients to the MedlinePlus web site and its contents that are applicable to a patient's health condition. The results describe the Program's potential to enhance patient education and interpersonal communication from physician and patient perspectives. The findings suggest once physicians adopt the use of an information prescription, they perceive they are providing an additional clinical service that enhances patient education and interpersonal communication. For physicians, participation in information prescription may improve patient communication, encourage information seeking, and lessen the number of poor quality Internet searches that patients frequently self-perform and bring to a doctor's office. Similarly, once patients receive a recommendation from a physician to seek health information on the web, patients may be more comfortable with health seeking on the Internet and discussing their findings with their doctor. The conclusions of the two evaluation studies imply an Information Prescription fosters a dialogue between providers and patients, helps patients use the Internet more effectively and seems to favorably impact patient education. As the medical community and patient advocacy groups continue to emphasize the importance of evidence-based information as the gold standard for accepted care, it can be expected that informatics tools such as Information Rx will come to play an increasingly important role as a vehicle to help identify and access high quality health information on the Internet.
Head-to-head comparison of Microflex LT and Vitek MS systems for routine identification of microorganisms by MALDI-TOF mass spectrometry in Chile

Background Matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry (MS) is a new and revolutionary identification method for microorganisms and has recently been introduced into clinical microbiology in many industrialized countries in Europe and North America. Objectives Our study aimed to compare the performance and practicality of two commercial MALDI-TOF MS platforms in a head-to head manner at a routine laboratory in Chile. Methods During a five-month period in 2012–13, the diagnostic efficiency (correct identification rate) and agreement between Microflex LT (Bruker Daltonics) and Vitek MS (bioMérieux) was compared in a parallel manner to conventional identification including genotypic analysis for difficult-to-identify strains. The study included 804 microbial isolates: 252 Enterobacteriaceae, 126 non-fermenters, 36 other gram-negative rods, 279 gram-positive cocci, 32 gram-positive rods, 32 anaerobes, and 47 yeasts. Other relevant factors of the two devices such as user friendliness and connectivity were also evaluated and compared. Results Both systems correctly identified the vast majority (98%) of the isolates to the genus level. Vitek MS reached higher rates of identification to species and species complex level than Microflex LT (81% vs. 85% and 87% vs. 93%, respectively), which was mainly based on the higher performance among coagulase negative staphylococci and Candida isolates. The evaluation of user friendliness and other technical aspects showed only marginal differences, which slightly favored Vitek MS, mainly due to its ready-to-use supplies, easier connectivity and workflow integration, and availability of local technical support. Conclusions Both MALDI-TOF MS systems permitted fast and accurate identification of most microbial strains and showed a high level of user-friendliness. The observed differences were marginal and slightly favored Vitek MS, mainly due to practicality and connectivity issues within our setting.
Suppression of the Biological Activities of the Epidermal Growth Factor (EGF)-like Domain by the Heparin-binding Domain of Heparin-binding EGF-like Growth Factor*

Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of growth factors that has a high affinity for heparin and heparan sulfate. While interactions with heparin are thought to modulate the biological activity of HB-EGF, the precise role of the heparin-binding domain has remained unclear. We analyzed the activity of wild-type HB-EGF and a mutant form lacking the heparin-binding domain (ΔHB) in the presence or absence of heparin. The activity of the EGF-like domain of HB-EGF was determined by measuring binding to diphtheria toxin (DT) as well as the growth factor activity in EGF receptor-expressing cells. The binding affinity of ΔHB for DT was much higher than that of wild-type HB-EGF in the absence of heparin. The binding affinity of HB-EGF for DT was increased by addition of exogenous heparin and reached the level close to the affinity of ΔHB, whereas that of ΔHB was not affected. Moreover, the growth factor activity of ΔHB was much higher than that of wild-type HB-EGF in the absence of heparin but was not affected by addition of exogenous heparin, whereas HB-EGF had increased growth factor activity with added heparin. These results indicate that the heparin-binding domain suppresses the activity of the EGF-like domain of HB-EGF and that association of heparin with HB-EGF via this domain removes the suppressive effect. Thus, we conclude that the heparin-binding domain serves as a negative regulator of this growth factor.
Simulations and measurements of the radio channel propagation parameters in urban and industrial environments for emergency localization

The need for cellular user localization is crucial in emergency case. For example, FCC require from wireless providers to localize the caller accuracy within 300 meters. Reliable knowledge of the radio propagation parameters will allow achieving better localization accuracy. In order to establish an efficient database of the received power for the development of localization algorithm, measurements and simulations were performed to investigate the quality of the predictions and to estimate the expected localization error. In this paper we have demonstrated that ray tracing simulations can predict in a relatively high accuracy the measured received power in real environments.
Treatment of venous thromboembolism in patients with cancer: Subgroup analysis of the Matisse clinical trials

Summary In the initial treatment of venous thromboembolism (VTE) fondaparinux, a pentasaccharide, is a good alternative to heparin. Whether this is also true for cancer patients is unknown. We performed two post-hoc analyses of two randomized studies to compare efficacy, safety and overall survival of fondaparinux to standard initial (low-molecular-weight) heparin (LMWH) treatment in cancer patients with venous thromboembolism. Two hundred thirty-seven cancer patients with deep venous thrombosis (DVT) were initially treated with fondaparinux or enoxaparin. Two hundred forty cancer patients with pulmonary embolism (PE) received fondaparinux or unfractionated heparin. The initial treatment was followed by vitamin K antagonists. In DVT patients, the three-month recurrence rate was 5.4% in the enoxaparin recipients compared to 12.7% in those treated with fondaparinux [absolute difference 7.3%, 95% CI 0.1, 14.5]. A recurrence was observed in 8.9% of the PE patients treated with fondaparinux compared to 17.2% in the unfractionated heparin recipients [absolute difference –8.3, 95% CI –16.7, 0.1]. In both studies no difference in bleeding and overall survival was observed. Regarding overall survival and bleeding fondaparinux is comparable to enoxaparin and unfractionated heparin in cancer patients. No significant differences in recurrent VTE were observed when comparing fondaparinux with unfractionated or LMWH. Because of study limitations these results should be considered hypothesis-generating.
"Wish Bias" in Antidepressant Drug Trials?

Abstract: The present study investigated whether the outcome of randomized clinical trials studying fluoxetine favored fluoxetine, where this was the experimental agent, and favored comparator antidepressants in trials where fluoxetine was the reference agent. A systematic review of all double-blind, randomized clinical trials comparing fluoxetine with any other antidepressant drug in patients suffering from depression was carried out. Thirty-seven studies meeting the inclusion criteria were analyzed. A metaregression analysis indicated that, after adjusting for possible confounders, studies where fluoxetine was the experimental agent were positively associated with treatment effect, indicating a significant advantage for fluoxetine. The evidence that the outcome of fluoxetine trials varied according to whether this drug was used as a new compound or a reference one suggests the presence of bias.
A review of the role of emergency nurses in management of chemotherapy-related complications.

AIMS AND OBJECTIVES To examine the role of emergency nurses in caring for patients who receive chemotherapy in ambulatory oncology settings. Reasons for emergency department presentations are examined, specific sources of clinical risk for patients receiving chemotherapy who require emergency care are discussed and cost implications of emergency department presentations related to chemotherapy are analysed. BACKGROUND Given the increased administration of chemotherapy in ambulatory settings, emergency nurses play an important role in the management of patients undergoing adjuvant chemotherapy. Emergency departments are the major entry point for acute inpatient hospital care of complications arising from chemotherapy. DESIGN Systematic review. RESULTS Chemotherapy-related emergency department presentations have considerable clinical and cost implications for patients and the healthcare system. Strategies to improve emergency department management of chemotherapy complications and reduction in preventable emergency department presentations has significant implications for improving cancer patients' quality of life and reducing the cost of cancer care. CONCLUSIONS Nurses are well placed to play a pivotal role in chemotherapy management and lead interventions such as a specialist oncology nursing roles that provide information and support to guide patients through their chemotherapy cycles. These interventions may prevent emergency department presentations for patients receiving chemotherapy in ambulatory settings. RELEVANCE TO CLINICAL PRACTICE Patients receiving chemotherapy require access to specialised care to manage distressing symptoms, as they are at significant clinical risk because of immunosuppression and may not exhibit the usual signs of critical illness. A team approach both within and across nursing specialities may improve care for patients receiving chemotherapy and increase effective use of healthcare resources.
Characterization of In40 of Enterobacter aerogenes BM2688, a Class 1 Integron with Two New Gene Cassettes, cmlA2 and qacF

ABSTRACT Enterobacter aerogenes BM2688, which is resistant to multiple antibiotics, and its aminoglycoside-susceptible derivative BM2688-1 were isolated from the same clinical sample. Strain BM2688 harbored plasmid pIP833, which carries a class 1 integron, In40, containing (in addition to qacEΔ1 and sul1, which are characteristic of class 1 integrons) four gene cassettes:aac(6′)-Ib, qacF, cmlA2, andoxa-9. The cmlA2 gene had 83.7% identity with the previously described nonenzymatic chloramphenicol resistancecmlA1 gene. The qacF gene conferred resistance to quaternary ammonium compounds and displayed a high degree of similarity with qacE (67.8% identity) which, however, has been found as part of a cassette with a very different 59-base element. The oxa-9 gene was not expressed due to a lack of promoter sequences. Study of the antibiotic-susceptible derivative BM2688-1 indicated that a 3,148-bp deletion between the 3′ end of theaac(6′)-Ib gene and the 3′ conserved segment of In40 was responsible for the loss of resistance. The occurrence of this DNA rearrangement, which did not involve homologous sequences, suggests that the In40 integrase could promote recombination at secondary sites.
Accounting for the Richness of Daily Activities

Serious consideration is being given to the impact of private behavior and public policies on people's subjective well-being (SWB). A new approach to measuring well-being, the day reconstruction method (DRM), weights the affective component of daily activities by their duration in order to construct temporal aggregates. However, the DRM neglects the potentially important role of thoughts. By adapting this method to include thoughts as well as feelings, we provide perhaps the most comprehensive measure of SWB to date. We show that some activities relatively low in pleasure (e.g., work and time with children) are nonetheless thought of as rewarding and therefore contribute to overall SWB. Such information may be important to policymakers wishing to promote behaviors that are conducive to a broader conception of SWB.
Light-stimulated release of dopamine from the primate retina is blocked by l-2-amino-4-phosphonobutyric acid (APB)

Macaca mulatta retinas were superfused, in vitro, to measure the efflux of dopamine. Steady light, in the low photopic range, stimulated dopamine release slightly. Flashing light (3 Hz) superimposed over the steady background increased dopamine efflux significantly. This increase was completely blocked by the addition of d,l-2-amino-4-phosphonobutyric acid (d,l-APB, 10–100 μM) to the superfusion medium, but not by the addition of the inactive enantiomer d-APB (10 μM). The results suggest that ON bipolar cells provide the excitatory drive to dopaminergic amacrine cells in primates, as in other species.
Examining Postadoption Usage of Mobile Services From a Dual Perspective of Enablers and Inhibitors

Users' postadoption usage is crucial to the success of mobile service providers. From a dual perspective, this research examined the effects of trust, satisfaction as enablers, and switching barrier as inhibitors on the postadoption usage of mobile services. A survey was used to collect data, and data analysis was conducted with structural equation modeling. The results indicated that trust, satisfaction, and switching barrier have significant effects on the postadoption usage. In addition, service quality and perceived value strongly affect trust and satisfaction, whereas switching cost determines switching barrier. These results advance our understanding of mobile users' postadoption usage as extant research has focused on using a single perspective of enablers such as perceived usefulness to examine mobile user behavior.