Miracle-dz/UniFAR-FTUs huggingface dataset:
Microrotary fatigue resistance of a HEMA-free all-in-one adhesive bonded to dentin.

PURPOSE To determine the effect of thorough air drying on the static and dynamic bonding effectiveness of a HEMA-free all-in-one adhesive bonded to Class-1 cavity-bottom dentin. MATERIALS AND METHODS G-Bond (GC, Japan) was applied to standard occlusal Class I cavities following either a gentle (1 bar) or strong (4 bar) air-drying technique. After restoring the cavity using a composite resin (Gradia Anterior, GC), microspecimens were prepared that were loaded until failure or inserted in a microrotary fatigue testing device. RESULTS Strong air drying had no effect on the static (39.1 vs. 38.4 MPa) or the dynamic (19.0 vs. 18.6 MPa) strength of the interface complex. CONCLUSION Strong air drying did not improve the static or the dynamic bonding effectiveness, although a very thorough (4 bar) and long air-drying procedure was employed. SEM analysis revealed that even when the adhesive was strongly air dried, droplets originating from phase separations could still be observed, albeit to a reduced extent. Ineffective drying and pooling of the adhesive in a narrow cavity diminished the effect of strong air drying of the all-in-one adhesive.
A Multicenter Randomized Double-blind Study of Enoxaparin Compared with Unfractionated Heparin in the Prevention of Venous Thromboembolic Disease in Elderly In-patients Bedridden for an Acute Medical Illness

Summary A multicenter, randomized double-blind study compared in two parallel groups the efficacy and safety of a low molecular weight heparin (LMWH) enoxaparin 20 mg once daily, with unfractionated heparin (UFH) 5000 IU twice daily, administered subcutaneously for 10 days, in the prevention of venous thrombosis disease in 442 hospitalized elderly patients bedridden for an acute medical illness. The main efficacy endpoint was defined as the occurrence of venous thrombosis, diagnosed by a daily fibrinogen uptake test, and/or documented clinical pulmonary embolism. Intention-to-treat analysis of efficacy showed that the incidence of venous thromboembolic events was low: 4.8% (10/207) in the LMWH group (9 episodes of isotopic venous thrombosis and one of scintigraphic pulmonary embolism), and 4.6% (10/216) in the UFH group (10 episodes of isotopic venous thrombosis). The two treatments were equivalent, where equivalence was defined as a maximum difference of 7% between the two groups (p = 0.0005). There were no significant differences in terms of safety between the 216 patients in the LMWH group and the 223 patients in the UFH group who received at least one injection of the randomized treatment. During the study period, 15 patients (3.4%) died (7 in the LMWH group and 8 in the UFH group): 2 sudden deaths, one in each group, including one case in which pulmonary embolism could not be excluded since no autopsy was performed, and 13 others deaths unrelated to the study treatments. Six patients (1.4%) presented a bleeding complication: 2 (0.9%) in the enoxaparin group (one major and one minor hemorrhage), and 4 (1.8%) in the UFH group (2 major and 2 minor hemorrhages). These results indicate that subcutaneous enoxaparin 20 mg once daily for 10 days is as effective and well tolerated as subcutaneous UFH 5000 IU twice daily in the prevention of venous thromboembolic disease in bedridden elderly in-patients presenting an acute medical illness.
LcrV Capture Enzyme-Linked Immunosorbent Assay for Detection of Yersinia pestis from Human Samples

ABSTRACT In the United States, there is currently a major gap in the diagnostic capabilities with regard to plague. To address this, we developed an antigen capture assay using an essential virulence factor secreted by Yersinia spp. , LcrV, as the target antigen. We generated anti-LcrV monoclonal antibodies (MAbs) and screened them for the ability to bind bacterially secreted native Yersinia pestis LcrV. Anti-LcrV MAb 19.31 was used as a capture antibody, and biotinylated MAb 40.1 was used for detection. The detection limit of this highly sensitive Yersinia LcrV capture enzyme-linked immunosorbent assay is 0.1 ng/ml. The assay detected LcrV from human sputum and blood samples treated with concentrations as low as 0.5 ng/ml of bacterially secreted native Y. pestis LcrV. This assay could be used as a tool to help confirm the diagnosis of plague in patients presenting with pneumonia.
Relationships of IGF-I and Androgens to Skeletal Maturation in Obese Children and Adolescents

UNLABELLED IGF-I and androgens are postulated to accelerate skeletal maturation in obese children. METHODS We studied weight status (BMI-SDS), height-SDS, IGF-I, cortisol, DHEA-S, and testosterone in 356 obese children (aged 4-15 years; 54% females) and correlated them to differences between bone age and chronological age (deltaBA-CA). Direct multivariate linear regression analyses were conducted for the dependent variable deltaBA-CA, including BMI, age, gender, pubertal stage, IGF-I-SDS, cortisol, DHEA-S, and testosterone as independent variables separately in prepubertal and pubertal girls, and prepubertal and pubertal boys. RESULTS Height-SDS (r = 0.52), IGF-I (r = 0.33), and IGF-I-SDS (r = 0.36) were significantly (p < 0.001) correlated to deltaBA-CA. In multiple regression analyses, BMI and IGF-I-SDS were significantly positively (p < 0.001) correlated to deltaBA-CA independently of gender and pubertal stage. Testosterone was significantly positively correlated to detaBA-CA only in prepubertal girls (p = 0.035). CONCLUSIONS Since IGF-I concentrations were positively associated to deltaBA-CA independently of pubertal stage and gender, we put forward the hypothesis that this hormone may contribute to acceleration of skeletal maturation in obese children.
Functional impairment in patients with mania: baseline results of the EMBLEM study.

OBJECTIVES The European Mania in Bipolar Longitudinal Evaluation of Medication (EMBLEM) is a large-scale prospective observational multicentre study to evaluate the longitudinal course of bipolar disorder and its associations with pharmacological treatment following an acute manic or mixed episode. We present an overview of the study design and patient characteristics at baseline while focusing on factors influencing work performance in the year prior to enrollment. METHODS A total of 530 investigators across 14 European countries enrolled 3,681 patients with acute mania between December 2002 and June 2004. Longitudinal observations are ongoing until July 2006. Socio-demographic variables, psychiatric history, clinical status and information on pharmacological treatment for bipolar disorder were recorded. Items from the SLICE of LIFE were applied, including a measure of work impairment during the previous year. The distribution of the baseline characteristics was analysed with descriptive statistics. Eighteen variables were investigated as hypothesized risk factors for work impairment applying logistic regression models. RESULTS In the previous year, 28 and 68% of patients were classified as having 'low' and 'high' work impairment, respectively. Clinical Global Impression - Bipolar Disorder (CGI-BP) overall, CGI-BP depression at baseline, rapid cycling during the previous 12 months, age between 35 and 64 years, substance abuse other than alcohol and cannabis and living without a partner or as dependent household member were significantly associated with work impairment during the previous year. CONCLUSIONS EMBLEM is to our knowledge the largest prospective observational study assessing patients during and after an acute episode of mania. Work impairment is significant in the year prior to an acute episode of mania.
Placental Tissue Interleukin‐10 Receptor Distribution in Pre‐eclampsia

PROBLEM: Reduced placental (trophoblast) cytokine interleukin‐10 (IL‐10) occurs in human pre‐eclampsia. Along with an increase in inflammatory cytokines this may play an important role in the development of hypertension in pregnancy. It is not clear whether the changes in placental IL‐10 are due to a change in the placental cell production of IL‐10 or a result of changes in cytokine receptor status in adjacent tissues. This study is aimed at qualifying the presence and distribution of IL‐10 receptors in women with a pre‐eclamptic outcome compared to normal pregnancy and gestational hypertension.
A MapReduce based Approach of Scalable Multidimensional Anonymization for Big Data Privacy Preservation on Hadoop

Bigdata privacy preservation is one of the most disturbed issues on the current industry. Data privacy issues need to be addressed urgently before data sets are shared on cloud. Data anonymization refers to as hiding complex data for owners of data records. In this paper investigate the problem of big data anonymization for privacy preservation from the perspectives of scalability and time factor etc. At present, the scale of data in many cloud applications increases tremendously in accordance with the big data trend. Here propose a scalable Two Phase Top-Down Specialization (TPTDS) approach to anonymize large-scale data sets using the MapReduce framework on cloud. For the data anonymization-45,222 records of adults information with 15 attribute values was taken as the input big data. With the help of multidimensional anonymization on map reducing framework, here implemented the proposed TwoPhase Top-Down Specialization anonymization algorithm on hadoop will increases the efficiency of the big data processing system. In both phases of the approach, deliberately design multidientional MapReduce jobs to concretely accomplish the specialization computation in a highly scalable way. Data sets are generalized in a topdown manner and the better result was shown in multidmientional MapReduce framework by compairing the onedimentional MapReduce framework anonymization job. The anonymization was performed with specialization operation on the taxonomy tree. The experiment demonstrates that the solutions can significantly improve the scalability and efficiency of big data privacy preservation compared to existing approaches. This work has great applications to both public and private sectors that share information to the society.
A brief review on correlates of physical activity and sedentariness in youth.

INTRODUCTION Better understanding of the correlates of physical activity and sedentary behaviors in youth will support the development of effective interventions that promote a physically active lifestyle and prevent a sedentary lifestyle. The main goal of this systematic review is to summarize and update the existing literature on correlates of young people's physical activity, insufficient physical activity, and sedentary behavior. METHODS A systematic review was conducted and included studies published between January 1999 and January 2005. RESULTS The 60 reviewed studies showed that for children (age range 4-12), gender (male), self-efficacy, parental physical activity (for boys), and parent support were positively associated with physical activity. For adolescents (age range 13-18), positive associations with physical activity were found for gender (male), parental education, attitude, self-efficacy, goal orientation/motivation, physical education/school sports, family influences, and friend support. For adolescents, a positive association was found between gender (male) and sedentary behavior, whereas an inverse association was found between gender and insufficient physical activity. Ethnicity (Caucasian), socioeconomic status, and parent education were found to be inversely associated with adolescents' sedentary behaviors. For children, the evidence was insufficient to draw conclusions about correlates of insufficient physical activity and sedentary behavior. CONCLUSION To gain more insight in the correlates of change in physical activity levels, more prospective studies are needed. Moreover, further research is needed examining the correlates of insufficient physical activity and sedentary behaviors, to develop effective interventions that may help children and adolescents diminish the time they spend on inactive behaviors.
Automatic Estimation of Tree Position and Stem Diameter Using a Moving Terrestrial Laser Scanner

Airborne laser scanning is now widely used for forest inventories. An essential part of inventory is a collection of field reference data including measurements of tree stem diameter at breast height (DBH). Traditionally this is acquired through manual measurements. The recent development of terrestrial laser scanning (TLS) systems in terms of capacity and weight have made these systems attractive tools for extracting DBH. Multiple TLS scans are often merged into a single point cloud before the information extraction. This technique requires good position and orientation accuracy for each scan location. In this study, we propose a novel method that can operate under a relatively coarse positioning and orientation solution. The method divides the laser measurements into limited time intervals determined by the laser scan rotation. Tree positions and DBH are then automatically extracted from each laser scan rotation. To improve tree identification, the estimated center points are subsequently processed by an iterative closest point algorithm. In a small reference data set from a single field plot consisting of 18 trees, it was found that 14 were automatically identified by this method. The estimated DBH had a mean differences of 0.9 cm and a root mean squared error of 1.5 cm. The proposed method enables fast and efficient data acquisition and a 250 m2 field plot was measured within 30 s.
The effect of secular trends in the classroom furniture mismatch: support for continuous update of school furniture standards

In order to create safer schools, the Chilean authorities published a Standard regarding school furniture dimensions. The aims of this study are twofold: to verify the existence of positive secular trend within the Chilean student population and to evaluate the potential mismatch between the anthropometric characteristics and the school furniture dimensions defined by the mentioned standard. The sample consists of 3078 subjects. Eight anthropometric measures were gathered, together with six furniture dimensions from the mentioned standard. There is an average increase for some dimensions within the Chilean student population over the past two decades. Accordingly, almost 18% of the students will find the seat height to be too high. Seat depth will be considered as being too shallow for 42.8% of the students. It can be concluded that the Chilean student population has increased in stature, which supports the need to revise and update the data from the mentioned Standard. Practitioner Summary: Positive secular trend resulted in high levels of mismatch if furniture is selected according to the current Chilean Standard which uses data collected more than 20 years ago. This study shows that school furniture standards need to be updated over time.
Prevalence of hypercoagulable disorders in inflammatory bowel disease

Abstract Objective. Inflammatory bowel disease (IBD) can be associated with hypercoagulable disorders. Aim of this single-center, prospective study was an in-depth evaluation of acquired hypercoagulable states in IBD patients. Methods. A total of 110 patients with Crohn's disease (CD) (aged 19–69; mean 40.5, median 38.5 years), 43 with ulcerative colitis (UC) (aged 17–72; mean 42, median 36 years), and 30 controls were enrolled. Full blood count, serum C-reactive protein (CRP), proteins C and S, activated protein C (APC) resistance, thrombin–antithrombin complex (TAT), F1+F2 fragments, tissue factor pathway inhibitor (TFPI) total and truncated, TFPI-factor Xa, tissue plasminogen activator (tPA) and PAI-I antigen were investigated in peripheral blood samples. Results. Only 18 of 153 (11.8%) IBD patients had hemocoagulation parameters within normal range. Significant difference between IBD patients and controls was found in thrombocyte volume (p < 0.001), protein C (p = 0.025), protein S (p = 0.003), APC resistance (p < 0.001), F1+F2 fragments (p < 0.001), and tPA (p = 0.002). In CD patients who were divided into two subgroups according to serum CRP values (non-active disease: <5 mg/L; active disease ≥5 mg/L), thrombocyte count was significantly lower (p = 0.001), thrombocyte volume was significantly higher (p = 0.002), F1+F2 fragments were significantly lower (p = 0.007) and tPA was significantly higher (p = 0.038) in the subgroup with CRP <5 mg/L. In UC patients, no significant difference depending on CRP was found. Conclusions. Acquired hypercoagulable abnormalities in IBD patients are frequent. Patients with active CD, but not UC, displayed significantly different hemocoagulable parameters, when compared to non-active CD/UC subjects. In patients with active CD (with increased serum CRP concentration) and patients with active extensive UC found at endoscopy (despite low CRP values), prophylactic anticoagulation therapy should be considered.
Silver nanoparticles: a brief review of cytotoxicity and genotoxicity of chemically and biogenically synthesized nanoparticles

In recent years interest in silver nanoparticles and their applications has increased mainly because of the important antimicrobial activities of these nanomaterials, allowing their use in several industrial sectors. However, together with these applications, there is increasing concerning related to the biological impacts of the use of silver nanoparticles on a large scale, and the possible risks to the environment and health. In this scenario, some recent studies have been published based on the investigation of potential inflammatory effects and diverse cellular impacts of silver nanoparticles. Another important issue related to nanoparticle toxicity in biological media is the capacity for increased damage to the genetic material, since nanoparticles are able to cross cell membranes and reach the cellular nucleus. In this regard, there is increasing interest in the analysis of potential nanoparticle genotoxicity, including the effects of different nanoparticle sizes and methods of synthesis. However, little is known about the genotoxicity of different silver nanoparticles and their effects on the DNA of organisms; thus further studies in this field are required. This mini‐review aims to present and to discuss recent publications related to genotoxicity and the cytotoxicity of silver nanoparticles in order to better understand the possible applications of these nanomaterials in a safe manner. This present work concludes that biogenic silver nanoparticles are generally less cyto/genotoxic in vivo compared with chemically synthesized nanoparticles. Furthermore, human cells were found to have a greater resistance to the toxic effects of silver nanoparticles in comparison with other organisms. Copyright © 2012 John Wiley & Sons, Ltd.
Earth, Landscape, Biotope, Plant. Interactive visualisation with Biosphere3D

1 ABSTRACT In this paper, we discuss the Digital Earth concept and scale issues regarding landscape planning visualisation, and we present the interactive visualisation system Biosphere3D. The visualisation system supports multiple scales on a virtual globe, and is focussing on real-time rendering of vegetation, similar to the predecessor Lenné3D-Player. In this paper we describe the visualisation system from a user's perspective. We provide detailed information about the available import and export data formats, the rendering capabilities and the required hardware. Additionally we will give a quick overview over the interfaces that allow the creation of custom software modules and possible applications.
The role of religious faith, spirituality and existential considerations among heart patients in a secular society: Relation to depressive symptoms 6 months post acute coronary syndrome

We explored the significance of religious faith/coping and spirituality and existential considerations reported during hospitalisation on depressive symptoms at 6-month follow-up and addressed patients’ perceived influence of their faith among 97 consecutive acute coronary syndrome patients (72.2% male patients; mean age, 60.6 years) in a secular society. All faith variables were found unrelated to depressive symptoms. Having unambiguous religious or spiritual faith at follow-up was associated with a perceived positive influence of this faith on quality of life and the disease itself compared to patients with ambiguous faith. These findings underscore the importance of examining degrees of faith in secular settings.
Geographical difference in antimicrobial resistance pattern of Helicobacter pylori clinical isolates from Indian patients: Multicentric study

Aim: To assess the pattern of antimicrobial resistance of Helicobacter pylori isolates from peptic ulcer disease patients of Chandigarh, Delhi, Lucknow, Hyderabad and Chennai in India, and to recommend an updated anti‐H. pylori treatment regimen to be used in these areas.
Coach Autonomy Support and Quality of Sport Engagement in Young Soccer Players

Based on the self-determination theory (Ryan & Deci, 2000), this study tested a model of the assumed sequential relationships between perceived autonomy support, psychological need satisfaction, self-determined motivation, and enjoyment/boredom. The hypothesized mediational roles of psychological need satisfaction and self-determined motivation were also studied. In a sample of 370 young male soccer players, path analysis results offered support for the proposed model. Total mediation was supported in the case of the psychological need satisfaction in the relationship between autonomy support and self-determined motivation, and partial mediation for self-determined motivation in the links between psychological need satisfaction and enjoyment (positive) and boredom (negative). Implications of autonomy-supportive behaviors provided by coaches for the quality of sport involvement among young athletes are discussed. En el marco de la teoría de la autodeterminación (Ryan & Deci, 2000), en este estudio se puso a prueba un modelo en el que se analizaron de forma secuencial las relaciones entre la percepción de apoyo a la autonomía del entrenador, la satisfacción de las necesidades psicológicas, la motivación autodeterminada y la diversión y el aburrimiento; así como el papel mediador hipotetizado de la satisfacción de las necesidades psicológicas y de la motivación autodeterminada. Los resultados del path análisis realizados con una muestra de 370 jóvenes futbolistas varones, ofrecieron apoyo al modelo propuesto. A su vez los análisis de mediación informaron que se producía una mediación total de la satisfacción de las necesidades psicológicas en las relaciones entre el apoyo a la autonomía y la motivación autodeterminada y una mediación parcial de la motivación autodeterminada con respecto a los enlaces entre la satisfacción de las necesidades psicológicas y la diversión (positivo) y aburrimiento (negativo). Se discuten las implicaciones que las conductas de apoyo a la autonomía del entrenador pueden tener para la calidad de la implicación deportiva en los jóvenes deportistas.