Miracle-dz/UniFAR-FTUs huggingface dataset:
Cumulative live-birth rates after in vitro fertilization.

BACKGROUND Outcomes of in vitro fertilization (IVF) treatment are traditionally reported as pregnancies per IVF cycle. However, a couple's primary concern is the chance of a live birth over an entire treatment course. METHODS We estimated cumulative live-birth rates among patients undergoing their first fresh-embryo, nondonor IVF cycle between 2000 and 2005 at one large center. Couples were followed until either discontinuation of treatment or delivery of a live-born infant. Analyses were stratified according to maternal age and performed with the use of both optimistic and conservative methods. Optimistic methods assumed that patients who did not return for subsequent IVF cycles would have the same chance of a pregnancy resulting in a live birth as patients who continued treatment; conservative methods assumed no live births among patients who did not return. RESULTS Among 6164 patients undergoing 14,248 cycles, the cumulative live-birth rate after 6 cycles was 72% (95% confidence interval [CI], 70 to 74) with the optimistic analysis and 51% (95% CI, 49 to 52) with the conservative analysis. Among patients who were younger than 35 years of age, the corresponding rates after six cycles were 86% (95% CI, 83 to 88) and 65% (95% CI, 64 to 67). Among patients who were 40 years of age or older, the corresponding rates were 42% (95% CI, 37 to 47) and 23% (95% CI, 21 to 25). The cumulative live-birth rate decreased with increasing age, and the age-stratified curves (< 35 vs. > or = 40 years) were significantly different from one another (P<0.001). CONCLUSIONS Our results indicate that IVF may largely overcome infertility in younger women, but it does not reverse the age-dependent decline in fertility.
Determinants of Capital Inflows: Evidence from Sri Lanka

This paper investigates the causes of capital flows into Sri Lanka in the form of push and pull factors, using the Fully Modified Ordinary Least Square (FMOLS) approach and the Vector Error Correction Model (VECM) for the period from 2001Q1 to 2015Q2. The study consists of four specifications that employ total capital inflows as a dependent variable and disaggregate the total capital inflows to main three categories. Based on empirical estimates, this study observes that capital flows get attracted largely due to pull factors such as real GDP, interest rate and political stability. The study also establishes that the fundamental causes of capital flows in disaggregate levels differ. These results suggest that Sri Lanka needs to pay close attention to keep domestic macroeconomic variables in the right order in order to attract foreign capitals.
The Role of Imagination in Exemplar Generation: The Effects of Conflict and Explanation

Structured imagination refers to reliance upon prior knowledge when generating novel examples of a provided category. Yet studies supporting this tenet use experimental designs where the stimuli themselves cue exemplars based on culturally relevant items. The present study combined exemplar generation with abstract stimuli as a means of attenuating instructional bias. Participants were shown a group of abstract shapes identified as a single category and instructed to generate another member of this category. We additionally examined whether the introduction of a cognitive conflict (by including an anomalous category member) and self-explanation during generation affected the level of imaginative responses. Contrary to expectations, the presentation of a conflicting category member did not result in more imaginative responses when compared to more homogenous stimuli sets. However, a significantly greater degree of imaginative responses was observed from participants who were required to explain their thinking prior to and whilst constructing their exemplars.
Action strategies of individuals during aperture crossing in nonconfined space

Walking through cluttered environments is a requirement of everyday locomotion, and individuals will walk toward open space and adjust their actions in order to prevent injury. When walking in a confined space, individuals require a shoulder rotation to pass through apertures smaller than 1.3 times their shoulder widths. The current study aimed to identify the action strategies employed by young adults to avoid contacting two obstacles placed in the travel path when walking in a nonconfined space. Participants (N = 12) walked along a 10-m path towards a goal while avoiding two vertical obstacles specifically placed to create an aperture (of 0.6 to 1.8 times the participants' shoulder widths) on opposite sides of the travel path midline. Results showed that participants walked around obstacles that were separated by less than 1.4 times their shoulder width (i.e., critical point). When participants deviated from their initial travel path, they did so by maintaining a consistent protective zone, regardless of the aperture width. The protective zone had dimensions of 3.80 m in the plane of progression and of 0.30 m between themselves and the obstacles at the time of crossing. This study demonstrates that individuals use body-scaled information to control actions in nonconfined space similar to that used in confined space.
[Influence of CD14 gene polymorphism on the expression of high mobility group box-1 protein in patients with severe burn].

OBJECTIVE To investigate the influence of the lipopolysaccharide receptor CD14-159C/T gene polymorphism on the synthesis and release of high mobility group box-1 protein (HMGB1), and its relation to sepsis in patients with severe burn. METHODS Venous blood from 35 patients with burn area equal to or larger than 30% TBSA was obtained on post burn day (PBD) 1, 3, 5, 7, 14, 21, and 28 respectively. Eleven volunteers were enrolled as healthy control group (HC). CD14-159C/T gene polymorphism was detected with polymerase chain reaction (PCR)-restriction fragment length polymorphism analysis. Plasma level of HMGB1 was determined with ELISA. Leukocyte HMGB1 mRNA expression was determined with RT-PCR. Data were processed with chi(2) test, analysis of variance, and t test. RESULTS Among the C-159T genotype of CD14 gene in the 35 patients, the distribution frequency of the T and the C allele was respectively 57.2% and 42.8%. Seven cases (20.0%) were homozygous for the C allele (CC), 16 cases (45.7%) were heterozygous (TC), and 12 cases (34.3%) were homozygous for the T allele (TT). Allele and genotype frequencies in cases were testified as reaching the Hard-Weinberg equilibrium. The incidence of sepsis was markedly lower in CC homozygous patients than in TC heterozygous and TT homozygous patients. Only one of the 3 septic patients in CC homozygous type died; 4 of 9 septic cases in TC heterozygous type and 4 of 7 septic cases in TT homozygous type died. Plasma levels of HMGB1 of patients were significantly elevated early on PBD 1 as compared with HC group, and higher values were found in TC heterozygous and TT homozygous patients than that in CC homozygous patients on PBD 14, 21, 28 (with F value respectively 3.5671, 4.2035, 3.8529, P < 0.05 or P < 0.01). Higher HMGB1 mRNA expression was found in septic patients as compared with non-sepsis patients on PBD 14 (1.5 +/- 0.5 vs. 1.2 +/- 0.4, t = -2.205, P < 0.05). Plasma level of HMGB1 was also respectively higher in septic patients than in non-sepsis patients on PBD 7, 21 [(44 +/- 29) ng/mL vs. (26 +/- 12) ng/mL, t = -2.355, P < 0.05; (25 +/- 15) ng/mL vs. (10 +/- 6) ng/mL, t = -3.872, P < 0.01)]. CONCLUSIONS CD14C-159T gene polymorphism might markedly influence the synthesis and release of HMGB1, and it is associated with increase in susceptibility of sepsis in patients with severe burn.
Comparison of two methods of collecting induced sputum in asthmatic subjects.

The method that we have previously reported for sputum induction involves collecting the entire expectorate produced over a 20 min inhalation of 3% saline aerosol. This method presents the potential disadvantage of a considerable and variable salivary contribution to the induced sputum sample. In this study, we examined whether separate collection of saliva and sputum represents a better method for collecting induced sputum during sputum induction. In 11 stable asthmatics, we compared the volume, total and differential cell counts, and eosinophil cationic protein (ECP) levels in four induced sputum samples, two performed using our previous method (Method A) and two using another method (Method B) in which subjects spit saliva into one container before coughing sputum into another. We found that the volume of sputum obtained with Method B was lower than that obtained with Method A (6.16 +/- 0.61 vs 20.1 +/- 2.7 mL; p = 0.003), as was the percentage of squamous cells (34 +/- 4 vs 47 +/- 6; p = 0.023). In addition, the ECP levels in samples collected by Method B were higher (261 +/- 42 vs 145 +/- 26 ng.mL-1; p = 0.01). The differential counts of nonsquamous cells were similar except for the percentage of neutrophils, which was lower in Method B (37 +/- 4 vs 50 +/- 5%; p = 0.019). The repeatability of measurements of eosinophil percentages and of ECP levels was similar for the two methods. We conclude that separate collection of saliva and sputum yields induced sputum samples with reduced amounts of saliva and is, therefore, a better method for collecting induced sputum.
Severity of children's psychopathology and impairment and its relationship to treatment setting.

OBJECTIVE The study investigated the settings in which children and adolescents were treated to determine whether clinicians assigned individuals who had greater needs to more intensive treatment. METHODS Subjects were 603 children four to 16 years of age who visited a mental health treatment facility in Western Australia, where, as is the case throughout Australia, universal publicly funded health care is provided. DSM-IV criteria were used to make diagnoses, and clinicians assessed each child's level of impairment. The clinicians assigned the children to inpatient treatment, day treatment, or outpatient treatment, or they saw the child only for a psychiatric consultation. Measures included parents' and children's reports of children's psychopathology and parents' reports of family functioning, family life events, and parental mental health symptoms and treatment. RESULTS Clinicians' ratings of impairment were highest for children assigned to the inpatient and day treatment settings. Parents' ratings of total psychopathology and of internalizing and externalizing symptoms were highest for children in the inpatient and day treatment settings. Parents' reports also indicated that family dysfunction and parental alcohol problems were most severe in the inpatient group. No differences in parents' mental health problems were found across treatment settings. CONCLUSIONS Children with more severe psychopathology and more severe family dysfunction and parental problems were more likely to be provided treatment in the most costly and time-intensive treatment settings. The results provide empirical evidence for what many clinicians consider best clinical practice-to assign children and families to treatment settings appropriate to their level of impairment.
Productive and lytic infection of human CD4+ type 1 helper T cells with macrophage-tropic human immunodeficiency virus type 1

It is generally recognized that macrophage-tropic human immunodeficiency virus type 1 (HIV-1) is the predominant population during the acute and asymptomatic phases of HIV-1 infection. Here, we compared the proliferation and syncytium-inducing activities of different HIV-1 strains in primary CD4+ T cells expressing various helper T (Th)-type cytokine profiles. The macrophage-tropic HIV-1 strains HIV-1JR-CSF, HIV-1NFN-SX, and HIV-1SF162 could proliferate vigorously and generate syncytia in primary CD4+ T cells irrespective of their Th subtype, in contrast to the T-cell-line-tropic HIV-1 strains HIV-1NL4-3 and HIV-1IIIB, which favored non-type 1 Th conditions. These results indicate that macrophage-tropic HIV-1 may be more invasive and virulent, since it kills more CD4+ Th1 cells than T-cell-line-tropic HIV-1 during the early stages of HIV-1 infection, when the Th1 immune response is dominant.
Do long-term bonds hedge equity risk? Evidence from Spain

We analyze the relationship between returns on equity and long-term government bonds in the Spanish economy. In particular, we are interested in the stability of the relationship across differing market conditions and if long-term bonds deliver diversification benefits during periods of equity market turbulence. Employing a Markov-switching vector autoregression model with three regimes, we find that the Spanish stock-bond relationship varies across market conditions and is positively correlated during ‘Bear’ markets. A sectoral analysis reveals that two sectors – Financials and Oil & Gas – are responsible for this positive comovement with the former being relatively more important. Classification- G01
Diffraction divergence of SH0 wave in thin piezoelectric plate of lithium niobate

By present time the profiles of aperture of Rayleigh surface acoustic wave (SAW) launching by interdigital transducers (IDTs) set on the surface of the wave-guide have been investigated in details. It has been shown that the SAW profile strongly depends on geometry of IDT and when moving off transducer the beam profile changes its shape. Recently the great interest of researchers was caused by acoustic waves in piezoelectric plates due to some advantages compared to surface acoustic waves. It has been also found that these waves are characterized by more values of angle between phase and group velocities (PFA). Plate waves may be effectively launched and received by IDTs. But the profiles of these waves along aperture were not investigated. This paper is devoted to experimental study of profiles of acoustic SH0 waves with shear-horizontal polarization, which propagates in piezoelectric plate of Y-X+220 lithium niobate. The profiles were studied by electrical probe set on the special precision mechanism, which allowed moving the probe in two directions. Because the wave was piezoactive it accompanied by alternating in time electrical field, which was detected by measuring probe. As a result the distribution of amplitude of electric field at different distances from launching IDT was measured. The measurement has shown that the profiles of SH0 wave significantly differ from ones of SAW. These profiles practically keep their shape at different distances from transducer but their amplitude and width change. The comparison with theoretical results showed their satisfactory compliance.
Optimization and Culture Conditions to Improve Helicobacter Pylori Growth in HAM's F-12 Medium by Response Surface Methodology

Helicobacter pylori is a gastroduodenal pathogen that colonizes the human stomach and is the causal agent of gastric diseases. From the clinical and epidemiological point of view, enhancing and improving the growth of this bacterium in liquid media is an important goal to achieve in order to allow the performance of accurate physiological studies. The aim of this work was to optimize three culture conditions that influence the growth of H. pylori in the defined medium Ham's F-12 supplemented with 5% fetal bovine serum by using response surface methodology as a statistical technique to obtain the optimal conditions. The factors studied in this experimental design (Box-Behnken design) were the pH of the medium, the shaking speed (rpm) and the percentage of atmospheric oxygen, in a total of 17 experiments. The biomass specific growth rate (μ) was the response measured. The model was validated for pH and shaking speed. The percentage of atmospheric oxygen did not influence the growth for the range of values studied. At the optimal values found for pH and shaking speed, 8 and 130 rpm, respectively, a specific growth rate value of 0.164 h−1, corresponding to a maximal concentration of approximately 1.5xl08 CFU/ml, was reached after 8 h. The experimental design strategy allowed, for the first time, the optimization of H. pylori growth in a semi-synthetic medium, which may be important to improve physiological and metabolic studies of this “fastidious” bacterium.
Magnetic resonance imaging for detection and analysis of mouse phenotypes

With the enormous and growing number of experimental and genetic mouse models of human disease, there is a need for efficient means of characterizing abnormalities in mouse anatomy and physiology. Adaptation of magnetic resonance imaging (MRI) to the scale of the mouse promises to address this challenge and make major contributions to biomedical research by non‐invasive assessment in the mouse. MRI is already emerging as an enabling technology providing informative and meaningful measures in a range of mouse models. In this review, recent progress in both in vivo and post mortem imaging is reported. Challenges unique to mouse MRI are also identified. In particular, the needs for high‐throughput imaging and comparative anatomical analyses in large biological studies are described and current efforts at handling these issues are presented. Copyright © 2005 John Wiley & Sons, Ltd.
Value of quantitative analysis of routine clinical MRI sequences in ALS

Abstract Simple morphological assessment of conventional MRI used in routine neurological diagnostic work-up lacks sensitivity and specificity for amyotrophic lateral sclerosis (ALS). Quantitative analysis of routine MRI sequences might, however, be more suitable to reveal ALS-related pathological cerebral alterations. We investigated 10 ALS patients and 10 age- and sex-matched healthy controls by MRI. Brain maps of T2 relaxation time (T2), relative proton density (PD), and apparent diffusion coefficient (ADC) were obtained. Values of these parameters were measured in 22 selected brain regions, and compared among the patients and the controls by using paired t-test with Bonferroni corrected alpha level (= 0.002). In ALS patients, increased PD was found in the pyramidal tract, corpus callosum, and white and grey matter. T2 elongation was found at the genu of corpus callosum, and at the posterior limb of the internal capsule (ICP). ADC values showed a tendency towards an increase in patients, which was only significant at the ICP. PD therefore appeared to be the most sensitive parameter for the detection of degenerative changes not only in the motor system but also in extramotor brain regions.
Proteomic analysis of Lyme disease: Global protein comparison of three strains of Borrelia burgdorferi

The Borrelia burgdorferi spirochete is the causative agent of Lyme disease, the most common tick‐borne disease in the United States. It has been studied extensively to help understand its pathogenicity of infection and how it can persist in different mammalian hosts. We report the proteomic analysis of the archetype B. burgdorferi B31 strain and two other strains (ND40, and JD‐1) having different Borrelia pathotypes using strong cation exchange fractionation of proteolytic peptides followed by high‐resolution, reversed phase capillary liquid chromatography coupled with ion trap tandem mass spectrometric analysis. Protein identification was facilitated by the availability of the complete B31 genome sequence. A total of 665 Borrelia proteins were identified representing ∼38% coverage of the theoretical B31 proteome. A significant overlap was observed between the identified proteins in direct comparisons between any two strains (>72%), but distinct differences were observed among identified hypothetical and outer membrane proteins of the three strains. Such a concurrent proteomic overview of three Borrelia strains based upon only the B31 genome sequence is shown to provide significant insights into the presence or absence of specific proteins and a broad overall comparison among strains.
The Intersection of Planning, Urban Agriculture, and Food Justice: A Review of the Literature

Problem, research strategy, and findings: We draw on a multidisciplinary body of research to consider how planning for urban agriculture can foster food justice by benefitting socioeconomically disadvantaged residents. The potential social benefits of urban agriculture include increased access to food, positive health impacts, skill building, community development, and connections to broader social change efforts. The literature suggests, however, caution in automatically conflating urban agriculture’s social benefits with the goals of food justice. Urban agriculture may reinforce and deepen societal inequities by benefitting better resourced organizations and the propertied class and contributing to the displacement of lower-income households. The precariousness of land access for urban agriculture is another limitation, particularly for disadvantaged communities. Planners have recently begun to pay increased attention to urban agriculture but should more explicitly support the goals of food justice in their urban agriculture policies and programs. Takeaway for practice: We suggest several key strategies for planners to more explicitly orient their urban agriculture efforts to support food justice, including prioritizing urban agriculture in long-term planning efforts, developing mutually respectful relationships with food justice organizations and urban agriculture participants from diverse backgrounds, targeting city investments in urban agriculture to benefit historically disadvantaged communities, increasing the amount of land permanently available for urban agriculture, and confronting the threats of gentrification and displacement from urban agriculture. We demonstrate how the city of Seattle (WA) used an equity lens in all of its programs to shift its urban agriculture planning to more explicitly foster food justice, providing clear examples for other cities.
Effect of hormone therapy and calcitriol on serum lipid profile in postmenopausal older women: association with estrogen receptor-&agr; genotypes

Objective:The aim of this study was to examine the effect of conjugated equine estrogens alone (ET), conjugated equine estrogens + medroxyprogesterone (EPT), calcitriol alone, calcitriol + EPT/ET, or placebo on serum lipid profile and analyze the interaction with estrogen receptor-&agr; gene single nucleotide polymorphisms (ESR-&agr; SNPs) on the response to therapy. Methods:A total of 489 postmenopausal women older than 65 years were enrolled into a 3-year double-blind, placebo-controlled clinical trial. Results:In both intent-to-treat and complier (>80% adherent) analysis, there was a significant increase in serum high-density lipoproteins and a significant decrease in serum low-density lipoproteins (LDLs) and the LDL/high-density lipoprotein ratio in all hormone treatment groups compared with placebo (P < 0.05). However, serum triglycerides and very low-density lipoproteins increased in the EPT and ET + calcitriol groups versus placebo (P < 0.05). ESR-&agr; SNPs PvuII and XbaI seemed to have a significant effect on the response to treatment. Genotypes containing the p allele showed a significantly greater decrease in serum cholesterol and very low-density lipoprotein than those having the P allele in the ET + calcitriol group (P < 0.05), and those with the x allele had a significantly greater decrease in serum cholesterol in the hormone therapy + calcitriol group at the end of 3 years versus the X allele, and a greater decrease in serum LDL in alleles x versus the X in the ET + calcitriol group (P < 0.05). Conclusions:ET with or without progesterone had a favorable effect on lipid profile in postmenopausal older women, and this was dependent on estrogen receptor SNPs-PvuII and XbaI. However, this interaction with ESR-&agr; SNPs needs to be confirmed in larger studies.