Miracle-dz/UniFAR-FTUs huggingface dataset:
Expression of RGD minus fibronectin that does not form extracellular matrix fibrils is sufficient to decrease tumor metastasis

Fibronectin (FN) is a plasma and extracellular matrix (ECM) glycoprotein, the expression of which may modulate the invasive and metastatic abilities of cancer cells. LMM3 is a cell line derived from the highly metastatic mouse mammary adenocarcinoma MM3 and is unable to express FN both at protein and mRNA levels. To study the role of FN in the metastatic process, LMM3 cells were stably transfected with 2 variants (wt and RGD‐minus) of a full length human FN cDNA. All analyzed clones secreted recombinant FN and although none assembled FN in the ECM they showed an in vitro reduced migratory ability and an increased adhesive capacity. FN‐producing cells were assayed for experimental and spontaneous metastasis. All clones tested showed a significant reduction in the number of experimental lung metastasis when compared with a control clone. Similar trends were observed for spontaneous metastatic ability. Our results indicate that the expression of FN that lacks the well‐recognized RGD cell‐binding site and that does not form ECM fibrils, is sufficient to decrease the metastatic potential of cancer cells. Our results also suggest that an RGD‐independent mechanism may be acting in the prevention of metastasis. Int. J. Cancer 78:233–241, 1998. © 1998 Wiley‐Liss, Inc.
Detecting Extinction Risk from Climate Change by IUCN Red List Criteria

Anthropogenic climate change is a key threat to global biodiversity. To inform strategic actions aimed at conserving biodiversity as climate changes, conservation planners need early warning of the risks faced by different species. The IUCN Red List criteria for threatened species are widely acknowledged as useful risk assessment tools for informing conservation under constraints imposed by limited data. However, doubts have been expressed about the ability of the criteria to detect risks imposed by potentially slow‐acting threats such as climate change, particularly because criteria addressing rates of population decline are assessed over time scales as short as 10 years. We used spatially explicit stochastic population models and dynamic species distribution models projected to future climates to determine how long before extinction a species would become eligible for listing as threatened based on the IUCN Red List criteria. We focused on a short‐lived frog species (Assa darlingtoni) chosen specifically to represent potential weaknesses in the criteria to allow detailed consideration of the analytical issues and to develop an approach for wider application. The criteria were more sensitive to climate change than previously anticipated; lead times between initial listing in a threatened category and predicted extinction varied from 40 to 80 years, depending on data availability. We attributed this sensitivity primarily to the ensemble properties of the criteria that assess contrasting symptoms of extinction risk. Nevertheless, we recommend the robustness of the criteria warrants further investigation across species with contrasting life histories and patterns of decline. The adequacy of these lead times for early warning depends on practicalities of environmental policy and management, bureaucratic or political inertia, and the anticipated species response times to management actions.
Recognizing Proper Names in UR III Texts through Supervised Learning

This paper reports on an ongoing effort to provide computational linguistic support to scholars making use of the writings from the Third Dynasty of Ur, especially those trying to link reports of ﬁnancial transactions together for the purpose of social networking. The computational experiments presented are especially addressed to the problem of identifying proper names for the ultimate purpose of reconstructing a social network of UR III society. We describe the application of established supervised learning algorithms, compare its results to previous work using unsupervised methods and propose future work based upon these comparative results.
Role of ischemic preconditioning on ischemia-reperfusion injury of the lung.

STUDY OBJECTIVES Ischemia-reperfusion injury of the lung frequently occurs after cardiopulmonary bypass, after pulmonary thromboembolectomy, and especially during lung transplantation. The protective effects of preconditioning on the heart, liver, bones, and various other organs have been previously evaluated. In this comparative study, we used isolated guinea pig lungs to show the effects of preconditioning on lung ischemia. METHODS The lungs (n = 10 in each group) were mounted on a modified Langendorff perfusion apparatus and perfused by Krebs-Henseleit solution for 30 min. We applied an ischemic preconditioning (5 min ischemia + 5 min perfusion, two times) in the experimental group. After 3 h of normothermic ischemia, the lungs were reperfused for 30 min. Pulmonary artery pressures and malondialdehyde (MDA) and glutathione (GSH) levels of the tissue and the perfusate were measured before and after the ischemic period and also at the end of reperfusion. Electron microscopic evaluation was done on randomly selected lungs of three animals in each group at the end of the experiment. RESULTS Both MDA and GSH levels of tissue and perfusate decreased in the experimental group after reperfusion, although the reduction in GSH levels did not reach statistical significance. The increase in pulmonary artery pressure was lower in the preconditioning group after reperfusion. CONCLUSIONS Our data showed that ischemic preconditioning of the lung may have a protective effect in ischemic-reperfusion injury.
Bronchial myeloid sarcoma with concurrent Aspergillus fumigatus infection in a patient presenting with hemoptysis

Myeloid sarcoma (MS) is an extramedullary myeloid neoplasm characterized by proliferation of myeloblasts which can occur in any organ or site. Bronchial and pulmonary involvement, however, is uncommon. We describe a case of bronchial MS in an 81-year-old female with a history of high-grade myelodysplastic syndrome; she was started on treatment few months before, and she presented with fever, cough and profuse hemoptysis. She was found to be pancytopenic with bilateral airspace consolidations, most notably in the right upper and lower lobes, on imaging studies. She was treated with broad-spectrum antibiotics and antifungals without much improvement in her clinical or radiological status. Ultimately, biopsy of the lung lesions showed myeloid sarcoma with concurrent Aspergillus fumigatus infection. Bronchial/pulmonary MS should be considered in the list of differential diagnoses in a patient with a history of myeloid neoplasm and presenting with respiratory related symptoms, as early administration of chemotherapy may help to improve survival rates.
Neuroticism and Extraversion Magnify Discrepancies Between Retrospective and Concurrent Affect Reports.

OBJECTIVE Although research often relies on retrospective affect self-reports, little is known about personality's role in retrospective reports and how these converge or deviate from affect reported in the moment. This micro-longitudinal study examines personality (Neuroticism, Extraversion) and emotional salience (peak and recent affect) associations with retrospective-momentary affect report discrepancies over different time frames. METHOD Participants were 179 adults aged 20-78 (M = 48.7 years; 73.7% Caucasian/White) who each provided up to 60 concurrent affect reports over 10 days, then retrospectively reported overall intensity of each affective state after 1 day and again after 1-2 months. RESULTS Multilevel models revealed that individuals retrospectively overreported or underreported various affective states, exhibiting peak associations for high arousal positive and negative affect, recency associations for low arousal positive affect, and distinct personality profiles that strengthened over time. Individuals high in both Extraversion and Neuroticism exaggerated high arousal positive and negative affect and underreported low arousal positive affect, high Extraversion/low Neuroticism individuals exaggerated high arousal positive affect and underreported low arousal positive affect, and low Extraversion/high Neuroticism individuals exaggerated high and low arousal negative affect. CONCLUSIONS This study is the first to identify arousal-specific retrospective affect report discrepancies over time and suggests retrospective reports also reflect personality differences in affective self-knowledge.
Serotonin and the Mammalian Circadian System: I. In Vitro Phase Shifts by Serotonergic Agonists and Antagonists

The primary mammalian circadian clock, located in the suprachiasmatic nuclei (SCN), receives a major input from the raphe nuclei. The role of this input is largely unknown, and is the focus of this research. The SCN clock survives in vitro, where it produces a 24-hr rhythm in spontaneous neuronal activity that is sustained for at least three cycles. The sensitivity of the SCN clock to drugs can therefore be tested in vitro by determining whether various compounds alter the phase of this rhythm. We have previously shown that the nonspecific serotonin (5-HT) agonist quipazine resets the SCN clock in vitro, inducing phase advances in the daytime and phase delays at night. These results suggest that the 5-HT-ergic input from the raphe nuclei can modulate the phase of the SCN circadian clock. In this study we began by using autoradiography to determine that the SCN contain abundant 5-HT 1A and 5-HT1B receptors, very few 5-HT1C and 5-HT 2 receptors, and no 5-HT3 receptors. Next we investigated the ability of 5-HT-ergic agonists and antagonists to reset the clock in vitro, in order to determine what type or types of 5-HT receptor(s) are functionally linked to the SCN clock. We began by providing further evidence of 5-HT-ergic effects in the SCN. We found that 5-HT mimicked the effects of quipazine, whereas the nonspecific 5-HT antagonist metergoline blocked these effects, in both the day and night. Next we found that the 5-HT1A agonist 8-OH-DPAT, and to a lesser extent the 5-HT1A-1B agonist RU 24969, mimicked the effects of quipazine during the subjective daytime, whereas the 5-HT 1A antagonist NAN-190 blocked quipazine's effects. None of the other specific agonists or antagonists we tried induced similar effects. This suggests that quipazine acts on 5-HT1A receptors in the daytime to advance the SCN clock. None of the specific agents we tried were able either to mimic or to block the actions of 5-HT or quipazine at circadian time 15. Thus, we were unable to determine the type of 5-HT receptor involved in nighttime phase delays by quipazine or 5-HT. However, since the dose-response curves for quipazine during the day and night are virtually identical, we hypothesize that the nighttime 5-HT receptor is a 5-HT1-like receptor.
Unique 3′‐untranslated sequence of insulin‐like growth factor‐I isolated from human placenta

A cDNA clone of 525 bp corresponding to the 3′‐untranslated region of insulin‐like growth factor‐I was isolated from a human placenta library. The sequence of this clone extended 200 nucleotides downstream from the previously reported 3′‐end of IGF‐IA cDNA, indicating the existence of IGF‐IA transcripts having an even larger 3′‐untranslated region. By using this clone for RNA transfer blot hybridization, it was shown that this longer 3′‐untranslated region is included in the 7.5‐ and 5.0‐kb transcripts, but not in the 1.1‐ and 0.9‐kb transcripts. It is also apparent that transcripts bearing the extended 3′‐untranslated sequence are highly expressed in human placenta.
A1 adenosine receptor activation induces ventriculomegaly and white matter loss

A1 adenosine receptors (A1ARs) are widely expressed in the brain during development. To examine whether A1AR activation can alter postnatal brain formation, neonatal rats from postnatal days 3 to 14 were treated with the A1AR agonist N6-cyclopentyladenosine (CPA) in the presence or absence of the peripheral A1AR antagonist 8-(p-sulfophenyl)-theophylline (8SPT). CPA or CPA + 8SPT treatment resulted in reductions in white matter volume, ventriculomegaly, and neuronal loss. Quantitative electron microscopy revealed reductions in total axon volume following A1AR agonist treatment. We also observed reduced expression of myelin basic protein in treated animals. Showing that functional A1ARs were present over the ranges of ages studies, high levels of specific [3H]CCPA binding were observed at PD 4, 7 and 14, and receptor-G protein coupling was present at each age. These observations show that activation of A1ARs with doses of CPA that mimic the effects of high adenosine levels results in damage to the developing brain.
HPV infection in cervical‐cancer cases in Russia

The presence of human papillomavirus (HPV) sequences in 21 biopsies from cervical carcinomas, II specimens of tissues adjacent to tumours, 2 specimens of cervical tissues with radiation fibrosis from patients after radiation therapy of cervical cancer and 7 normal epithelial tissues from the patients with other genital tumours were examined by polymerase chain reaction (PCR) and Southern‐blot analysis. All tumours were HPV‐positive by type‐specific PCR and 86% by Southern‐blot analysis. In normal epithelial and adjacent tissues, HPV sequences were detected in 20% of samples by Southern‐blot analysis and in 70% of samples by PCR, including 2 cases of tissues after radiation therapy. HPV 16 was the most prevalent type in tumours (18/21) as well as in normal epithelial tissues (5/7). One HPV‐positive tumour contained HPV18 DNA and 2 were doubly infected with HPVs 16 and 18 (2/21). The persistence of exclusively episomal HPV16 DNA was observed in 5 out of 11 tumours examined: 3 cases of squamous‐cell carcinomas on the early stage of tumour progression and 2 advanced tumours (squamous‐cell carcinoma and adenocarcinoma). The integration of HPV16 genome was detected in 6 out of 11 tumours, but most of them contained episomal forms of viral DNA simultaneously (5 out of 6). The integrative HPV18 genome was found in 2 tumours examined, and the persistence of episomal forms was also observed in one of them. Our data demonstrate that cervical tumours are associated invariably with high‐risk types of HPV in Russia. © 1995 Wiley‐Liss, Inc.
Realising M-Payments: modelling consumers' willingness to M-pay using Smart Phones

It is predicted that significant and ongoing investment in M-Commerce platforms and application development by commercial entities will fundamentally change consumers' shopping and web browsing behaviours. However, the evolving behaviour of Smart Phone users is somewhat tempered by concerns over M-Payments. If Smart Phones are to reach their full M-Commerce potential, the ability of consumers to transact and pay for products/services through these devices in an easy, safe and reliable manner must be addressed. In response, this paper contributes a theoretical model and empirically tests the model to explore Irish consumers' perceptions of using Smart Phones to make M-Payments for products/services. The findings present conclusive evidence that trust is the most powerful factor influencing consumers' willingness to use Smart Phones to make M-Payments. While perceived usefulness and perceived ease of use influence the payment decision, their impact is much lower. Mobile self-efficacy and personal innovativeness have almost no direct impact. The paper concludes that irrespective of individuals' high levels of personal innovativeness or mobile self-efficacy and irrespective of whether Smart Mobile Media Services are perceived as useful and easy to use, consumers will not make M-Payments, until they are convinced that Smart Phone M-Payment systems are safe and reliable.
Bitcoin 1, Bitcoin 2, ....: An Experiment in Privately Issued Outside Monies

The value of Bitcoin depends upon self-fulfilling beliefs that are hard to pin down. We demonstrate this for the case where Bitcoin is the only form of money in the economy and then generalize the message to the case of multiple Bitcoin clones and/or a competing sovereign currency. Some aspects of the indeterminacy we describe would no longer hold if Bitcoin were an interesting-bearing object.
Regenerator placement algorithms for connection establishment in all-optical networks

We deal with the problem of establishing a lightpath in a multihop manner under physical constraints. We provide both minimal-cost and heuristic algorithms for locating signal regeneration nodes (SRNs). For a minimal-cost algorithm, we formulate the problem using dynamic programming (DP) such that blocking of other lightpaths due to the lack of transmitters/receivers (TXs/RXs) and wavelengths is minimized throughout the network. The blocking performances of several algorithms are compared with one another in a ring.
Prospective analysis of atypical epithelial cells as a high‐risk cytologic feature for malignancy in pancreatic cysts

Pancreatic cysts are aspirated to assess whether a cyst is mucinous on one hand and malignant on the other. The authors' retrospective data have indicated that high‐grade atypical epithelial cells (AECs) identified on cytology are a high‐risk feature and a better threshold than “positive” for detecting malignancy. The objective of the current study was to assess the accuracy of AECs in predicting malignancy in pancreatic cysts.
Multiple variable cues in the environment promote accurate and robust word learning

Learning how words refer to aspects of the environment is a complex task, but one that is supported by numerous cues within the environment which constrain the possibilities for matching words to their intended referents. In this paper we tested the predictions of a computational model of multiple cue integration for word learning, that predicted variation in the presence of cues provides an optimal learning situation. In a cross-situational learning task with adult participants, we varied the reliability of presence of distributional, prosodic, and gestural cues. We found that the best learning occurred when cues were often present, but not always. The effect of variability increased the salience of individual cues for the learner, but resulted in robust learning that was not vulnerable to individual cues’ presence or absence. Thus, variability of multiple cues in the language-learning environment provided the optimal circumstances for word learning.
On Stable and Strategy-Proof Rules in Matching Markets with Contracts

This paper studies stable and (one-sided) strategy-proof rules in many-to-one matching markets with contracts. Not assuming any kind of substitutes condition or the law of aggregate demand, we obtain the following results. First, the number of stable and strategy-proof rules is at most one. Second, the doctor-optimal stable rule, whenever it exists, is the unique candidate for a stable and strategy-proof rule. Third, a stable and strategy-proof rule, whenever it exists, is second-best optimal for doctor welfare, in that no individually rational and strategy-proof rule can dominate it. This last result is further generalized to non-wasteful and strategy-proof rules. Due to the weak assumptions, our analysis covers a broad range of markets, including cases where a (unique) stable and strategy-proof rule is not equal to the one induced by the cumulative offer process or the deferred acceptance algorithm.
PHARMACOKINETICS AND DISPOSITION

Objective: We studied the pharmacokinetics and pharmacodynamics of single and multiple doses of candesartan cilexetil 8 mg per day in hypertensive patients with dierent degrees of renal function impairment. Candesartan is an angiotensin II subtype 1 (AT1) receptor antagonist that is administered orally as candesartan cilexetil which is converted in the active compound. Methods: Twenty-three patients were included, divided into groups according to creatinine clearance (cr cl. group A >60 nl ámin á 1.73 m, group B 30±60 ml á min á 1.73 m and group C 15±30 ml ámin á 1.73 m). Results: Trough serum concentrations of candesartan were higher in group C compared with group A. The values did not increase after multiple dosing, indicating absence of accumulation. There was a signi®cant negative correlation between the area under the concentrationtime curve extrapolated to time in®nity (AUCinf) and the glomerular ®ltration rate (GFR) indicating a lower renal clearance of candesartan in patients with impaired renal function. The onset of haemodynamic and hormonal effects was gradual. During the single-dose study blood pressure as well as plasma renin activity (PRA) and angiotensin II were unchanged at peak. At day 5 of the multiple-dose study blood pressure was lower and both PRA and angiotensin II were higher compared with baseline. Conclusion: Although serum trough levels increased during repeated administration and half-life was higher in patients with impaired renal function, candesartan cilexetil at a dose of 8 mg per day does not lead to drug accumulation in these patients. This dose is eective in lowering blood pressure and appears to be suitable for patients with renal function impairment.
College Students’ Perceptions of Barriers to Bystander Intervention

Sexual violence is a major problem on college campuses and is associated with a range of negative health consequences for victims. Teaching students to intervene as prosocial bystanders has become a common element of sexual assault prevention efforts; although these programs have demonstrated positive effects on participants’ beliefs and knowledge, their impact on actual behavior is weaker. Understanding the factors that inhibit intervening in risky situations may enhance the effectiveness of bystander programs by identifying material that addresses these barriers. A sample of 281 first-year college students indicated whether they had encountered 10 situations that may present elevated risk of sexual or physical assault since arriving on campus, and if so, whether they had done something to intervene. If they had not intervened, they were asked to identify the barriers that had inhibited them. Participants also completed measures of two factors proposed to predict bystander behavior, self-efficacy and emotion regulation. A majority of participants intervened in most of the situations, but only 27% of participants intervened in every situation they encountered. Men and women differed in the barriers they identified most frequently across situations, with men endorsing Perceived Responsibility more often than women, and women reporting Skill Deficits more often than men. Neither men nor women perceived Audience Inhibition to be a significant barrier; it was salient in only one of the 10 situations. Students higher in global bystander self-efficacy were more likely to intervene and less likely to report barriers related to skill deficits and perceived responsibility. These results suggest that existing bystander intervention programs efforts can be improved by fostering a greater sense of collective responsibility in students and teaching specific intervention behaviors.