Miracle-dz/UniFAR-FTUs huggingface dataset:
Muscular failure training in conditioninig neuromuscular programs

Many recommendations for designing of resistance training programs are suggested training all the sets to perform until voluntary fatigue with a maximum load selected, situation known as muscular failure. However, recent evidence has emerged that suggest caution in the prescription of training to failure in both, healthy and performance perspective. This review has addressed to this issue and made a collection of literature and a qualitative analysis of this topic. Final conclusion of this study suggest that implementation of the muscular failure resistance training is not recommended in subjects who trained with healthy goals, because it breaks the acceptable risk-benefit ratio in healthy training. However, athletes or advanced practitioners can be applied wishing to exceed a "plateau", only if planned and does not interfere with the production of specific strength.
Assessment and characterization of the diet of an isolated population in the Bolivian Andes

Objectives: The goal of this research is to characterize the composition and nutrient adequacy of the diets in the northern region of the Department of Potosí, Bolivia. Communities in this semiarid, mountainous region are isolated and impoverished having the highest rates of child malnutrition and under‐five mortality in the Americas.
Neuromuscular Adaptations to Constant vs. Variable Resistance Training in Older Men

Abstract This study examined the effects of constant or variable external resistance training on neuromuscular adaptations in the lower limbs of older men. 37 subjects (age 65±4 year) were quasi-randomly assigned to the constant or variable training group, or a non-training control group. Training consisted of a 20-week medium-intensity, high volume resistance training program. Maximum bilateral concentric and isometric force production of the leg extensors as well as repetitions-to-failure test were performed pre-, mid- and post-training. Vastus lateralis muscle cross-sectional area was assessed by ultrasound and lean leg mass was assessed by dual-energy x-ray absorptiometry. Both training groups significantly increased force production of the leg extensors (variable: 26 kg, 95% CI=12–39, P<0.01; constant: 31 kg, 95% CI=19–43, P<0.01) and VL cross-sectional area (variable: 1.5 cm2, 95% CI=0.03–3.1, P=0.046; constant: 3 cm2, 95% CI=1.2–4.8, P=0.002). However, only the variable training group significantly improved repetitions to failure performance (704 kg, 95% CI=45–1 364, P=0.035). Only the variable resistance training group improved fatigue-resistance properties, which may be an important adaptation to maintain exercise and functional capacity in older individuals.
Equation-based precise prediction of length of hamstring tendons and quadrupled graft diameter by various anthropometric variables for knee ligament reconstruction in Indian population

Preoperative prediction of hamstring tendon lengths and graft diameter for anterior cruciate ligament (ACL) reconstruction enables better preoperative planning. Presently, no study exists for Indian population where both derivation and verification of a mathematical equation for accurate prediction of hamstring graft dimensions have been done. This study was conducted in two phases: First phase (derivation cohort): devoted to the study of correlation of length of hamstring tendons and graft diameter with various anthropometric measurements in 123 patients undergoing ACL reconstruction. Length of semitendinosus (ST) was observed to have a strong correlation with leg length (r = 0.719), whereas that of gracilis (G) had a strong correlation with patient height (r = 0.768). Quadrupled diameter (QD) had a strong correlation with patient height and thigh length (r = 0.685 and 0.680, respectively). Using Pearson correlation coefficient, multiple stepwise linear regressions, and analysis of variance test, predictive equations were developed to predict the length of ST and G and QD. Second phase (verification cohort): This was a blinded prospective study done on 300 patients to further authenticate and test the accuracy of equations developed. Here, a steady correlation was found between the observed and predicted values of length of ST, G and QD, with correlation coefficients being 0.838, 0.847, and 0.767, respectively. Thus, we can safely conclude that clinically measurable anthropometric variables can reliably predict hamstring graft dimensions. This is likely to prove useful in better preoperative planning of ligament reconstructions.
Immune Reconstitution Following Rabbit Antithymocyte Globulin

Depletional induction therapies are routinely used to prevent acute rejection and improve transplant outcome. The effects of depleting agents on T‐cell subsets and subsequent T‐cell reconstitution are incompletely defined. We used flow cytometry to examine the effects of rabbit antithymocyte globulin (rATG) on the peripheral T‐cell repertoire of pediatric and adult renal transplant recipients. We found that while rATG effectively depleted CD45RA+CD27+ naïve and CD45RO+CD27+ central memory CD4+ T cells, it had little effect on CD45RO+CD27− CD4+ effector memory or CD45RA+CD31−, CD45RO+CD27+ and CD45RO+CD27− CD8+ T cell subsets. When we performed a kinetic analysis of CD31+ recent thymic emigrants and CD45RA+/RO+ T cells, we found evidence for both thymopoiesis and homeostatic proliferation contributing to immune reconstitution. We additionally examined the impact of rATG on peripheral CD4+Foxp3+ T cells. We found that in adults, administration of rATG‐induced peripheral expansion and new thymic emigration of T cells with a Treg phenotype, while CD4+Foxp3+ T cells of thymic origin predominated in children, providing the first evidence that rATG induces Treg in vivo. Collectively our data indicate that rATG alters the balance of regulatory to memory effector T cells posttransplant, providing an explanation for how it positively impacts transplant outcome.
Investigation of statistical parameters of the evolving wind wave field using a laser slope gauge

Statistical parameters of water waves generated by wind in a small scale facility are studied using extensively a Laser Slope Gauge (LSG), in addition to conventional measuring instruments such as a wave gauge and Pitot tube. The LSG enables direct measurements of two components of the instantaneous surface slope. Long sampling duration in a relatively small experimental facility allowed accumulating records of the measured parameters containing a large number of waves. Data were accumulated for a range of wind velocities at multiple fetches. Frequency spectra of the surface elevation and of the instantaneous local slope variation measured under identical conditions are compared. Higher moments of the surface slope are presented. Information on the waves’ asymmetry is retrieved from the computed skewness of the surface slope components.
University of Birmingham Efficient adaptive stochastic Galerkin methods for parametric operator equations

This paper is concerned with the design and implementation of eﬃcient solution algorithms for elliptic PDE problems with correlated random data. The energy orthogonality that is built into stochastic Galerkin approximations is cleverly exploited to give an innovative energy error estimation strategy that utilizes the tensor product structure of the approximation space. An associated error estimator is constructed and shown theoretically and numerically to be an eﬀective mechanism for driving an adaptive re(cid:12)nement process. The codes used in the numerical studies are available online.
Response of broilers to moenomycin.

Abstract DURING screening for new antibiotics, Lindner and Wallhausser (1955) isolated a previously undescribed antibiotic from an antibiotic-producing streptomyces strain. This compound was designated moenomycin. The fermentation and isolation of this antibiotic are described by Wallhausser et al. (1965). Chemical characterization of the antibiotic by Huber et al. (1965) indicated that moenomycin is a mixture of at least four active components, which belong to a group of phosphorus-containing glycolipid antibiotics which are conspicuous by their tendency to form high molecular associates. Wasielewski et al. (1965) reported that moenomycin has an antibacterial spectrum which is similar to that of penicillin. No cross-resistance was found in strains resistant to several antibiotics. It was found to be effective against some experimental infections of mice by parental administration. However, there was almost no absorption from the gastrointestinal tract. Bauer and Dost (1965) added moenomycin to the diet of broilers, swine, calves, and laying hens. Their…
Plasma gonadotropin II, sex steroids, and thyroid hormones in wild striped bass (Morone saxatilis) during spermiation and final oocyte maturation.

The blood levels of gonadotropin II (GtH II), sex-steroid hormones, and thyroid hormones were determined in wild spermiating male striped bass (Morone saxatilis) in males and in females at various stages of final oocyte maturation (FOM), captured on their spawning grounds. The progression of spermiation was associated with increases in plasma GtH II and decreases in plasma testosterone (T), 11-ketotestosterone, and thyroxine (T4). Plasma triiodothyronine (T3) remained at high and relatively unchanged levels. Plasma levels of 17,20beta-dihydroxy-4-pregnen-3-one (17,20beta-P) and 17,20beta, 21-trihydroxy-4-pregnen-3-one (17,20beta,21-P), the proposed maturation-inducing steroids (MIS) in striped bass, were low and unchanged during the same period. It was concluded that low progestogen levels are adequate to induce spermiation in striped bass, and that higher levels may be associated with spawning behavior. In the females, based on the profiles of the studied hormones, FOM was separated into two phases. Early FOM, which included germinal vesicle (GV) migration and lipid-droplet coalescence, was associated with elevations in plasma GtH II, T, and estradiol 17beta. Late FOM, which included GV breakdown and yolk-globule coalescence, was associated with a further surge in plasma GtH II, increases in the levels of the two MIS, mainly 17, 20beta-P, and a drop in T4. Plasma T3 levels did not change during FOM. Examination of conjugated steroids demonstrated, in the males, a reduction in conjugated androgens at the peak of the spawning season and, in the females, a small increase in conjugated 17, 20beta-dihydroxylated and 5beta-reduced,3alpha-hydroxylated steroids after spawning. This is the most comprehensive report, to date, on the endocrine regulation of gonadal maturation in wild striped bass, demonstrating that a two-stage process of FOM is regulated by different endocrine signals, providing further evidence for the involvement of 17,20beta-P as a MIS in the females, and indicating that both males and females are in an euthyroid state during the spawning season.
L2 Gain Performance Analysis of Linear Switched Systems: Fast Switching Behavior

We investigate the L2 gain of switched linear systems under fast switching. For systems that possess a suitable notion of a time-average system, we characterize the relationship between the L2 gain of the switched system and the L2 gain of its induced time-average system when the switching rate is sufficiently fast. We show that the switched system L2 gain is in general different from the average system L2 gain if the input or output matrix switches. If only the state coefficient matrix switches, the input-output energy gain for a fixed L2 input signal is bounded by the L2 gain of the average system as the switching rate grows large. Additionally for a fixed L2 input, the maximum pointwise in time difference between the switched and average system outputs approaches zero as the switching rate grows.
Evaluating clinical change and visual function concerns in drivers and nondrivers with glaucoma.

PURPOSE To compare drivers and nondrivers, and to describe the specific concerns of drivers, among individuals with glaucoma. METHODS Six hundred seven patients with newly diagnosed glaucoma treated at 14 clinical centers of the Collaborative Initial Glaucoma Treatment Study were randomly assigned to initial medicine or surgery and were followed up every 6 months. Driving status (drivers versus nondrivers) and patient-reported visual function were determined by the Visual Activities Questionnaire and the National Eye Institute Visual Function Questionnaire. Clinical evaluation included visual field mean deviation (MD) and visual acuity. Statistical comparisons were made using t, chi(2), and exact tests and regression and Rasch analyses. RESULTS Drivers were more likely than nondrivers to be male, white, married, employed, and more educated and to have higher incomes and fewer comorbidities. More than 50% of drivers reported at least "some" difficulty performing tasks involving glare, whereas 22% reported at least "some" difficulty with tasks requiring peripheral vision. At 54 months, drivers with moderate/severe bilateral visual field loss (VFL) reported greater difficulty with night driving and tasks involving visual search and visual processing speed than drivers with less bilateral VFL (all P<0.05). Although those who remained drivers over follow-up had better MD in both eyes than those who became nondrivers because of eyesight, a number of drivers had marked VFL. CONCLUSIONS Inquiring about specific difficulties with tasks related to glare, visual processing speed, visual search, and peripheral vision in driving, especially among patients with substantial bilateral visual field damage, will enable physicians to more effectively counsel patients regarding driving.
Consensual Lay Profiles of Narcissism and Their Connection to the Five-Factor Narcissism Inventory

Although there is evidence that experts agree on the traits that characterize narcissism, this agreement may be due, in part, to the influence of the operationalizations based on the American Psychiatric Association’s series of Diagnostic and Statistical Manuals of Mental Disorders (American Psychiatric Association [APA], 1980, 1994, 2013). Because these trait descriptions are important in shaping conceptualizations and serving as empirical criteria for construct validation, we explored their generalizability. In Study 1, we collected lay ratings (N = 1,792) of prototypical cases of narcissism across 15 different categories (e.g., gender, age, occupational status) on the 30 traits of the five-factor model (FFM). There was good agreement within and across rating categories and the trait profiles were quite similar to existing ratings made by academicians and clinicians. In Study 2 (N = 603), we examined the degree to which various scores from the Five-Factor Narcissism Inventory–Short Form (FFNI-SF; Sherman et al., 2015) provided empirical matches to these FFM profiles (mean lay ratings from Study 1; existing expert-based and meta-analytically derived profiles). In general, scores from the FFNI-SF grandiose scale, as well as the empirically derived FFNI-SF Antagonism and Agentic Extraversion components yielded FFM profiles closely aligned to the various consensus profiles. These results are generally consistent with a burgeoning literature that suggests that the FFNI/FFNI-SF is a promising tool for the study of narcissism given its comprehensiveness, flexibility, and ties to the predominant model of personality.
Improvement of magnetomechanical properties of cobalt ferrite by magnetic annealing

We report dramatic improvements in both magnetostriction level and strain derivative of polycrystalline cobalt ferrite as a result of magnetic annealing. Magnetostrictive cobalt ferrite composites have potential for use in advanced magnetomechanical stress and torque sensors due to their high sensitivity of magnetization to applied stresses and high levels of magnetostriction. Results show that annealing cobalt ferrite at 300/spl deg/C in air for 36 h under a dc field of 318 kA/m (4 kOe) induced a uniaxial anisotropy with the easy axis being along the annealing field direction. Under hard axis applied fields, the maximum magnetostriction measured along the hard axis at room temperature increased in magnitude from -200/spl times/10/sup -6/to -252/spl times/10/sup -6/ after annealing. The maximum strain derivative (d/spl lambda//dH)/sub max/, which is related to stress sensitivity, increased from 1.5/spl times/10/sup -9/ A/sup -1/m to 3.9/spl times/10/sup -9/ A/sup -1/m. The results can be interpreted in terms of the effects of induced uniaxial anisotropy on the domain structure and magnetization processes.
Pharmacogenetics in type 2 diabetes: influence on response to oral hypoglycemic agents

Type 2 diabetes is one of the leading causes of morbidity and mortality, consuming a significant proportion of public health spending. Oral hypoglycemic agents (OHAs) are the frontline treatment approaches after lifestyle changes. However, huge interindividual variation in response to OHAs results in unnecessary treatment failure. In addition to nongenetic factors, genetic factors are thought to contribute to much of such variability, highlighting the importance of the potential of pharmacogenetics to improve therapeutic outcome. Despite the presence of conflicting results, significant progress has been made in an effort to identify the genetic markers associated with pharmacokinetics, pharmacodynamics, and ultimately therapeutic response and/or adverse outcomes to OHAs. As such, this article presents a comprehensive review of current knowledge on pharmacogenetics of OHAs and provides insights into knowledge gaps and future directions.
Poly(ADP-ribose) Polymerase-2 (PARP-2) Is Required for Efficient Base Excision DNA Repair in Association with PARP-1 and XRCC1*

The DNA damage dependence of poly(ADP-ribose) polymerase-2 (PARP-2) activity is suggestive of its implication in genome surveillance and protection. Here we show that the PARP-2 gene, mainly expressed in actively dividing tissues follows, but to a smaller extent, that of PARP-1 during mouse development. We found that PARP-2 and PARP-1 homo- and heterodimerize; the interacting interfaces, sites of reciprocal modification, have been mapped. PARP-2 was also found to interact with three other proteins involved in the base excision repair pathway: x-ray cross complementing factor 1 (XRCC1), DNA polymerase β, and DNA ligase III, already known as partners of PARP-1. XRCC1 negatively regulates PARP-2 activity, as it does for PARP-1, while being a polymer acceptor for both PARP-1 and PARP-2. To gain insight into the physiological role of PARP-2 in response to genotoxic stress, we developed by gene disruption mice deficient in PARP-2. Following treatment by the alkylating agentN-nitroso-N-methylurea (MNU), PARP-2-deficient cells displayed an important delay in DNA strand breaks resealing, similar to that observed in PARP-1 deficient cells, thus confirming that PARP-2 is also an active player in base excision repair despite its low capacity to synthesize ADP-ribose polymers.
Carcinogenicity of Dietary Dimethylnitrosomorpholine, N-methyl-N'-Nitro-N-Nitrosoguanidine, and Dibromoethane in Rainbow Trout

Eighteen-mo feeding trials of rainbow trout were used to test the carcinogenicity of 5 chemicals in this species. A single exposure level was used for each substance. The doses and chemicals tested were 1,556 ppm 2,6-dimethylnltrosomorpholine (DMNM), 500 ppm N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), 2,000 ppm 1,2-dibromoethane (DBE), 2,000 ppm 1,1-dichloroethylene (DCE), and 200 ppm cyclophosphamide (CP). Liver and/or glandular stomach neoplasms were produced by DMNM (liver and stomach), MNNG (stomach), and DBE (chiefly, stomach tumors). In addition, DMNM produced a low incidence of swimbladder papillomas and caused testicular atrophy in 50% of treated males. DCE and CP produced no neoplasms at the exposure levels used. No evidence of other chronic toxicity was seen for any of the 5 compounds.
Effects of equine recombinant interleukin-1alpha and interleukin-1beta on proteoglycan metabolism and prostaglandin E2 synthesis in equine articular cartilage explants.

OBJECTIVES To evaluate the effects of equine recombinant interleukin-1alpha (rEqIL-1alpha) and recombinant interleukin-1beta (rEqIL-1beta) on proteoglycan metabolism and prostaglandin E2 (PGE2) synthesis by equine articular chondrocytes in explant culture. SAMPLE POPULATION Near full-thickness articular cartilage explants (approx 50 mg) harvested from stifle joints of a 3-year-old and a 5-year-old horse. PROCEDURE Expression constructs containing cDNA sequences encoding EqIL-1alpha and EqIL-1beta were generated, prokaryotically expressed, and the recombinant protein purified. Near full-thickness articular cartilage explants (approx 50 mg) harvested from stifle joints of a 3-year-old and a 5-year-old horse were separately randomized to receive rEqIL-1alpha or rEqIL-1beta treatments 10 to 500 ng/ml). Proteoglycan release was evaluated by 1,9-dimethylmethylene blue spectrophotometric analysis of explant media glycosaminoglycan (GAG) concentration and release of 35S-sulfate-labeled GAG to explant media. Proteoglycan synthesis was assessed by quantification of 35S-sulfate incorporation into proteoglycan. Explant media PGE2 concentrations were evaluated using a PGE2-specific enzyme-linked immunoassay. Data were collected at 48-hour intervals and normalized by DNA content. RESULTS Proteoglycan release was induced by rEqIL-1alpha and rEqIL-1beta at concentrations > or =0.1 ng/ml, with 38 to 76% and 88 to 98% of total GAG released by 4 and 6 days, respectively. Inhibition of proteoglycan synthesis (42 to 64%) was observed at IL-1 concentrations > or = 0.1 ng/ml at 2 and 4 days. Increased PGE2 concentrations were observed at IL-1 concentrations > or = 0.1 ng/ml at 2 and 4 days. CONCLUSIONS AND CLINICAL RELEVANCE The rEqIL-1 induced potent concentration-dependent derangement of equine chondrocyte metabolism in vitro. These findings suggest this model may be suitable for the in vitro study of the pathogenesis and treatment of joint disease in horses.
Linguistic knowledge in statistical phrase-based word alignment

In this paper, a novel phrase alignment strategy combining linguistic knowledge and cooccurrence measures extracted from bilingual corpora is presented. The algorithm is mainly divided into four steps, namely phrase selection and classification, phrase alignment, one-to-one word alignment and postprocessing. The first stage selects a linguistically-derived set of phrases that convey a unified meaning during translation and are therefore aligned together in parallel texts. These phrases include verb phrases, idiomatic expressions and date expressions. During the second stage, very high precision links between these selected phrases for both languages are produced. The third step performs a statistical word alignment using association measures and link probabilities with the remaining unaligned tokens, and finally the fourth stage takes final decisions on unaligned tokens based on linguistic knowledge. Experiments are reported for an English-Spanish parallel corpus, with a detailed description of the evaluation measure and manual reference used. Results show that phrase cooccurrence measures convey a complementary information to word cooccurrences and a stronger evidence of a correct alignment, successfully introducing linguistic knowledge in a statistical word alignment scheme. Precision, Recall and Alignment Error Rate (AER) results are presented, outperforming state-of-the-art alignment algorithms.