Miracle-dz/UniFAR-FTUs huggingface dataset:
Heparin Management in a Patient with Thyroid Storm

Management of atrial fibrillation during thyroid storm includes anticoagulation for risk of clot propagation. Physiologic changes that occur in patients with thyroid storm may lead to heparin resistance and inappropriate anticoagulation. Factors contributing to heparin resistance include antithrombin deficiency, increased heparin clearance, and increased levels of factor VIII. We describe a 30–year‐old woman who was hospitalized with thyroid storm. She subsequently developed atrial fibrillation, and unfractionated heparin was started. Over the next 4 days, the heparin infusion rate was titrated to an exaggerated dose of 2100 units/hour (33 units/kg/hr) in order to attain a therapeutic response. By hospital day 7, her atrial fibrillation had resolved; the heparin infusion was discontinued, and the patient remained clinically stable with no sequelae. The exact mechanism of heparin resistance in thyroid storm is unknown; however, data have shown a positive correlation between factor VIII and thyroxine levels. This patient had an elevated thyroxine level of 32.5 μg/dl, which suggested that an increased factor VIII level was the probable mechanism of heparin resistance. Recognition of possible heparin resistance in patients with thyroid storm will allow clinicians to promptly identify appropriate interventions to ensure adequate anticoagulation in this high‐risk patient population. Key Words: hyperthyroidism, thyroid storm, unfractionated heparin, UFH, heparin resistance, activated partial thromboplastin time.
Morphology of transcriptional units at different states of activity.

The morphology of two forms of transcriptionally active chromatin, the nucleoli and the loops of lampbrush chromosomes, has been examined after fixation in situ or after isolation and dispersion of the material in media of low ionic strengths, using a variety of electron microscopic preparation techniques (e.g. spread preparations with positive or negative staining or without any staining at all, with bright and dark field illumination, with autoradiography, after pretreatment of the chromatin with specific detergents such as Sarkosyl NL-30; transmission and scanning transmission electron microscopy of ultrathin sections). Nucleolar chromatin and chromosomes from oocytes of various amphibia and insects as well as from green algae of the family of the Dasycladaceae were studied in particular detail. The morphology of transcriptional units that are densely packed with lateral ribonucleoprotein fibrils, indicative of great transcriptional activity, was compared with that of chromatin of reduced lateral fibril density, including stages of drug-induced inhibition. The micrographs showed that under conditions which preserve the nucleosomal organization in condensed chromatin studied in parallel, nucleosomes are not recognized in transcriptionally active chromatin. This holds for the transcribed regions as well as for apparently untranscribed (i.e. fibril-free) regions interspersed between (‘spacer’) and/or adjacent to transcribed genes and for the fibril-free regions within transcriptional units of reduced fibril density. In addition, comparison of lengths of repeating units of isolated rDNA with those observed in spread nucleolar chromatin indicated that this DNA is not foreshortened and packed into nucleosomal structures. Granular particles which were observed, at irregular frequencies and in variable patterns, in some spacer regions, did not result in a proportional shortening of the spacer axis, and were found to be resistant to detergent treatment effective in removing most of the chromatin associated proteins including histones. Thus, these particles behave like RNA polymerases rather than nucleosomes. It is suggested that structural changes from nucleosomal packing to an extended form of DNA are involved in the transcriptional activation of chromatin.
The capital structure, business extension and profitable performance of construction enterprises——civil engineering listed company taken as an example

In order to explore and analyze the contribution of capital structure and business extension to the profitable performance in the large Civil Engineering Construction Enterprises pointedly, this article, based on the mixed data in the recent 5 to 7 years of 21 Listed Company of Civil Engineering Construction Enterprises in China with the method of panel data analysis, has measured the contribution of variables such as capital structure, business extension to the profitable performance of enterprises from three dimensions, which are asset return, total asset payment, and operating profit. Research finds:(1) Although there exist significant differences regarding to asset structure, business extension, and enterprise scale among the Companies of Civil Engineering Construction Enterprises Listed, the rate of operating profit, total asset return, and the level of management performance tend to be similar, and are almost below the average level;(2) The management performance and the business extension have negative restrictions to the profitable performance of enterprises.
Morphology and life cycle of a new species of Didymium (Myxomycetes) from arid areas of Mexico

A new species of myxomycete, Didymium umbilicatum, isolated from the bark of Agavaceae, is described from arid zones of Mexico. This species was obtained from moist chamber cultures of Yucca spp. bark, collected in four different years from two states (Puebla and Querétaro) in central Mexico and found in the field from Hidalgo, Oaxaca and Puebla on the dead remains of Agave sp. The new species has small, flat, white sporocarps or short plasmodiocarps, 0.2–1.3 mm diam, and 0.15–0.4 mm tall. They are sessile on a reduced base or have a short, calcareous pale stalk and warted spores, warts fused in an irregular subreticulum by SEM. It is the sixth species of Didymium recently described from arid areas. The stability of the taxonomic characters of the species was confirmed by spore-to-spore culture on agar. Life cycle events are described from germination to sporulation. The morphology of the myxomycete specimens was examined with scanning electron microscopy and light microscopy, and micrographs of relevant details are included.
Prevalence, risk factors, and genotype distribution of hepatitis C virus infection in the general population: A community‐based survey in southern Italy

In 1996 the prevalence, risk factors, and genotype distribution of hepatitis C virus (HCV) infection were assessed in the general population of a town in southern Italy. The sample was selected from the census by a systematic 1:4 sampling procedure. The participation rate was 96.6%. Among the 1,352 subjects enrolled, 195 (14.4%) tested reactive to antibody to HCV (anti‐HCV) with enzyme immunoassay (EIA 3). When further tested with recombinant immunoblot assay (RIBA 3), 170 subjects (87.2%) tested positive, 23 subjects (11.8%) had indeterminate results, and 2 subjects (1%) tested negative. Thus, the overall anti‐HCV EIA‐positive RIBA‐confirmed prevalence was 12.6% (170 of 1,352 subjects) and increased from 1.3% in subjects younger than 30 years to 33.1% in those ≥ 60 years of age. This latter age group accounted for 72.3% of all anti‐HCV‐positive subjects. Females tested positive more frequently than males (14.1% vs. 10.5%; P < .05). Alanine transaminase (ALT) concentrations were abnormal in only 4.1% (7/170) of anti‐HCV EIA‐positive RIBA‐confirmed subjects. This suggests that ALT screening is not useful in the detection of anti‐HCV‐positive subjects in a general population. The results of multiple logistic regression analysis showed that an age of less than 45 years, the use of glass syringes, and dental therapy were all independent predictors of anti‐HCV positivity. HCV RNA was detected by polymerase chain reaction in 75.9% of the 195 anti‐HCV EIA‐positive subjects: in 84.7% (144/170) of the RIBA‐confirmed subjects; in 17.4% (4/23) tested as RIBA indeterminate; and in neither of the two subjects who tested RIBA negative. HCV type 1b was detected in 75 subjects (50.7%), type 2b in 1 subject (0.7%), type 2c in 66 subjects (44.6%), type 3a in 4 subjects (2.7%), and type 4 in two subjects (1.3%). These figures differ from those of Italian patients with chronic liver disease in whom genotype 2 is more rare. None of the individuals was infected with more than one genotype. The distribution of the two most common HCV viral types (1b and 2c) was not statistically different in terms of mean age, sex, or risk factors and suggests that they may have had a parallel spread in this community. These findings provide one of the highest overall anti‐HCV prevalence rates in a general population with a likely cohort effect, i.e., decreased risk of infection along generations. These observations may indicate an epidemic or focus of hepatitis C that occurred several years earlier. The majority of anti‐HCV–positive subjects in the oldest age group and with no clinical evidence suggests that HCV infection is a very prolonged and indolent disease.
Ion Activity Products of Calcium Carbonate in Waters Below the Root Zone1

The pH, Ca²⁺, and HCO₃⁻ relations were investigated in 28 well waters obtained from beneath irrigated fields in Arizona. The mean [Ca] [CO₃] ion activity product (IAP) was 11.3 × 10⁻⁹ (pIAP = 7.95) with a standard error of 0.7 × 10⁻⁹ based on field measurements of pH. As indicated by ionic strength the residence time of the waters in the soil vary widely. The lack of a trend in pIAP vs. ionic strength indicates the kinetics of calcite equilibration (from supersaturation) is quite slow in soil-water systems. This conclusion was supported by an average pIAP of 7.97 calculated from 35 water analyses obtained from wells in the Grand Valley of Colorado and by a pIAP value of 7.96 obtained from a soil water sample in a lysimeter study. Since these pIAP values are quite consistent and were obtained under a wide variety of conditions, a pIAP value of 7.95 is recommended for use in predictive models when CaCO₃ precipitation occurs.
Dual priority scheduling

In this paper, we present a new strategy for scheduling tasks with soft deadlines in real-time systems containing periodic, sporadic and adaptive tasks with hard deadlines. In such systems, much of the spare capacity present is due to sporadic and adaptive tasks not arriving at their maximum rate. Offline methods of identifying spare capacity such as the Deferrable Server or Priority Exchange Algorithm are unable to make this spare capacity available as anything other than a background service opportunity for soft tasks. Further, more recent methods such as dynamic Slack Stealing require computationally expensive re-evaluation of the available slack in order to reclaim such spare capacity. By comparison, the Dual Priority approach presented in this paper provides an efficient and effective means of scheduling soft task in this case.
The psychological disturbances associated with 345 pregnancies in 137 women.

Summary A general practice study of psychological disorders associated with childbearing is reported. Thirty-three of 137 women who had been delivered at term at least once since 1955 had a record of psychological disturbance on at least one occasion in pregnancy or the post-partum year. The rate for reactive disorders in the year after delivery was 19 per 1,000, about one-fifth the one-year prevalence rate for women of similar age in the practice population as a whole. The rate for depression with endogenous features during this year was 26 per 1,000, about five times the equivalent annual prevalence rate and nearly all the attacks occurred within three months of delivery. There is some evidence that delivery precipitates endogenous depression.
Clinicopathologic and Prognostic Significance of Carboxyl Terminus of Hsp70-interacting Protein in HBV-related Hepatocellular Carcinoma.

BACKGROUND Many factors, including molecular ones, were demonstrated to be associated with long-term prognosis of hepatocellular carcinoma (HCC). Thus far, the expression and clinicopathologic and prognostic significance of the carboxyl terminus of Hsp70-interacting protein (CHIP) in B-type hepatitis virus (HBV)- related HCC remain unknown. MATERIALS AND METHODS CHIP expression was detected by immunohistochemical staining of surgical samples from 79 patients with HCC with HBsAg positivity. In addition, correlations with clinicopathologic parameters and patient survival were evaluated. RESULTS It was found that positive CHIP staining was observed in tumor, but not non-tumor, tissues. High expression of CHIP was significantly related to larger tumor size, with marginally significant associations noted for presence of portal vein invasion and higher serum a-fetoprotein level. In addition, univariate analysis showed that high CHIP expression was a powerful predictor for dismal overall and disease-free survival. However, independent prognostic implications of CHIP were not proven in multivariate Cox regression test. CONCLUSIONS CHIP is overexpressed in HBV-related HCC and is associated with unfavorable biological behavior as well as poor prognosis. However, its prognostic role needs to be further validated.
The performance status scale for head and neck cancer patients and the functional assessment of cancer therapy‐head and neck scale: A study of utility and validity

The goal of this investigation was to examine the relationship between, and application of, two disease specific quality of life (QL) measures currently being employed for head and neck cancer patients: the Functional Assessment of Cancer Therapy‐Head and Neck Scale (FACT‐H & N) and the Performance Status Scale for Head and Neck Cancer Patients (PSS‐HN).
Measuring the Impact of Cultural Competence Training for Dental Hygiene Students.

Purpose: The purpose of this study was to measure the change in levels of knowledge of providing culturally competent care and self-assessed cultural competence of senior level dental hygiene students after the implementation of an online cultural competence training module.Methods: Twenty-eight members of the senior class of 31 dental hygiene students (N=28) volunteered to participate in this IRB approved study at the Ohio State University School of Dentistry. The students took the online Inventory for Assessing the Process of Cultural Competence- Student Version (IAPCC-SV), to assess their self-perceived cultural competence. Upon completion of the pre-test, students then completed the United States Department of Health and Human Services (HHS) Office of Minority Health (OMH) Cultural Competency Program for Oral Health Professionals; a three-module online training program designed to measure increased knowledge of cultural competence. Three weeks following the initial pre-test and upon completion of the Cultural Competency Program for Oral Health Professionals online learning modules, students re-took the IAPCC-SV.Results: Twenty-eight senior dental hygiene students completed the IAPCC-SV pre-test, the OMH e-learning modules and the IAPCC-SV post-test. The average score on the pre-test was 55.14±7.54 and the average score on the post-test was 61.33±7.86. There was a significant difference in pre-test and post-test scores (p<0.001). There were also significant differences in the constructs of knowledge of cultural competence (p<0.001) and skill (p<0.001). Conclusion: The HHS OMH Cultural Competency Program for Oral Health Professionals was effective for increasing dental hygiene students' levels of knowledge of cultural competence.
Can Tweets Predict Intraday Stock Price Movements

Twitter is a microblogging platform where over 320 million people post about things that matter to them in less than 140 characters. People post about their happiness, sadness, pride, disappointments, love, hate, expectations and other feelings. Nowadays, a popular trend has come up in which data from Twitter, can be gathered and analyzed in real time to see how people react to a particular situation including changes in stock markets. This research focuses on looking into the relationship, if any, between public mood from Twitter and the stock market returns by analyzing the Tweets about four major companies in consumer discretionary industry namely Amazon, Walt Disney, Home Depot and Comcast and their stock price over the duration of about a month. The research showed causal relationship between market sentiment corresponding to a particular stock and their stock returns.
Efficacy and safety of lorcaserin in obese adults: a meta‐analysis of 1‐year randomized controlled trials (RCTs) and narrative review on short‐term RCTs

Lorcaserin is a new anti‐obesity drug recently approved by US Food and Drug Administration. We conducted a systematic review and meta‐analysis of randomized controlled trials (RCTs) to evaluate the association of lorcaserin therapy with weight loss and adverse events in obese adults (18–65 years old). Weight loss of 3.23 kg (95% confidence interval [CI]: 2.70, 3.75) and body mass index reduction of 1.16 kg m−2 (95% CI: 0.98, 1.34) was observed compared with placebo in RCTs of 1 year duration. The use of lorcaserin for 8 and 12 weeks reduced weight of 1.60 kg (95% CI: 0.34, 2.86) and 2.9 kg (95% CI: 2.2, 3.5), respectively. In comparison to placebo, lorcaserin decreased waist circumference, blood pressure, total cholesterol, low‐density lipoprotein‐cholesterol and triglycerides, however did not statistically affect heart rate or high‐density lipoprotein‐cholesterol. Headache, nausea and dizziness were found to be significantly higher in the patients receiving lorcaserin than patients receiving placebo, whereas diarrhoea is no more likely than in patients receiving placebo. In conclusion, lorcaserin achieves modest weight loss and appears to be well tolerated. Clinical and pharmacovigilance studies with longer study duration are needed to inform of the long‐term efficacy and safety of lorcaserin.
Age-Dependent Penetrance of Disease in a Transgenic Mouse Model of Familial Amyotrophic Lateral Sclerosis

The mutation gly93-->ala of Cu,Zn superoxide dismutase (SOD) is found in patients with familial amyotrophic lateral sclerosis and causes motor neuron disease when expressed in transgenic mice. The progression of clinical and pathological disease was studied in a line of mice designated G1H. Clinical disease started at 91 +/- 14 days of age with fine shaking of the limbs, followed by paralysis and death by 136 +/- 7 days of age. Pathological changes begin by 37 days of age with vacuoles derived from swollen mitochondria accumulating in motor neurons. At the onset of clinical disease (90 days), significant death of somatic motor neurons innervating limb muscles has occurred; mice at end-stage disease (136 days) show up to 50% loss of cervical and lumbar motor neurons. However, neither thoracic nor cranial motor neurons show appreciable loss despite vacuolar changes. Autonomic motor neurons also are not affected. Mice that express wild-type human Cu,Zn SOD remain free of disease, indicating that mutations cause neuron loss by a gain-of-function. Thus, the age-dependent penetrance of motor neuron disease in this transgenic model is due to the gradual accumulation of pathological damage in select populations of cholinergic neurons.
Red Wine Consumption Is Associated with Fecal Microbiota and Malondialdehyde in a Human Population

Objectives: Red wine intake has been associated with a lower risk of cardiovascular disease; its polyphenol content is the primary cause of antioxidant and anti-inflammatory properties attributed to this beverage. However, the way in which these activities are exerted is not yet clear, although some authors have proposed that intestinal microbiota could be implicated. Methods: The association between red wine intake, inflammation, and oxidative stress parameters and fecal microbial populations has been explored in 38 adult volunteers. Food intake was recorded by means of an annual food frequency questionnaire (FFQ). Energy, cholesterol, and ethanol intake were analyzed using the nutrient Food Composition Tables developed by Centro de Enseñanza Superior de Nutrición y Dietética (CESNID) and polyphenol intake was obtained from the Phenol-Explorer Database. Fecal levels of Akkermansia, Bacteroides, Bifidobacterium, Blautia coccoides group, Clostridium leptum group, Lactobacillus group, and Faecalibacterium prausnitzii were determined by quantitative polymerase chain reaction. Serum concentrations of C-reactive protein (CRP), malondialdehyde (MDA), total antioxidant capacity (TAC), cholesterol, triglycerides and glucose were analyzed by standard methods. Results: Subjects with regular consumption of red wine (mean = 100 ml/day) had lower serum concentrations of MDA and lower fecal levels of B. coccoides, C. leptum, Bifidobacterium, and Lactobacillus. A positive association between MDA levels and B. coccoides and Lactobacillus was also found. Conclusion: Regular consumption of red wine appears to be associated with a reduced serum lipoperoxidation in which the intestinal microbiota may be involved.
Relationships between the metabolism of high‐density and very‐low‐density lipoproteins in man: studies of apolipoprotein kinetics and adipose tissue lipoprotein lipase activity

Abstract. In order to gain further insight into the relationship between high‐density lipoprotein (HDL) metabolism and plasma triglyceride transport, measurements were made of HDL cholesterol concentration, apoprotein (apo) AI and AII metabolism, very‐low‐density lipoprotein (VLDL) apo B metabolism, and heparin‐elutable adipose tissue lipoprotein lipase (LPL) activity in seventeen subjects with a wide range of plasma triglyceride concentrations (0.8–25 mmol/l).
Why people in Benin are reluctant to undergo amputations? A systematic inventory of motives

We made an inventory of the reasons for inhabitants of Benin are reluctant to undergo the amputation of a limb. A robust six-factor structure of motives was found: Change in Appearance, Lack of Information, Fear of Hospitals and Medical Staff, Loss of Others’ Consideration and Affection, Denial of Necessity, and Spiritual and Religious Concerns. The first three motives were the most strongly endorsed. To improve people’s timely acceptance, it is important to attack the main emotional–motivational barriers by using artificial limbs imitating real ones, by providing complete information on post-operative care and rehabilitation, and by strengthening family support.
Chromanol 293B Inhibits Slowly Activating Delayed Rectifier and Transient Outward Currents in Canine Left Ventricular Myocytes

Chromanol 293B on Ionic Currents. Introduction: Drugs that selectively inhibit the slowly activating component of the delayed rectifier potassium current (IKs) are being considered as possible antiarrhythmic agents, because they produce more prolongation of action potential duration at fast rates with less transmural dispersion of repolarization compared with blockers of the rapidly activating component (IKr). Although the chromanol derivative chromanol 293B has been shown to be relatively selective in blocking IKs in some species, its selectivity is far from established.