Miracle-dz/UniFAR-FTUs huggingface dataset:
Neuropsychiatric Manifestations of Osmotic Demyelination Syndrome Secondary to Overcorrection of Severe Hyponatraemia in Hyperemesis Gravidarum: A Case Report

Osmotic demyelination syndrome (ODS) may occur as a consequence of a rapid change in serum osmolality. We report a case of a 32-year-old woman who presented to the hospital with symptoms suggestive of severe hyperemesis gravidarum. Blood investigation results showed that patient had severe hyponatraemia (serum sodium 109 mmol/L) and hypokalaemia (serum potassium 1.7 mmol/L). Active and vigorous corrections to these electrolyte imbalances had led to an overly increased of serum sodium levels within a short duration of time. Four days after the rapid correction, patient started exhibiting neuropsychiatric manifestations. Radiological findings were consistent with the diagnosis of ODS. The neuropsychiatric symptoms experienced by patient gradually worsened with time. Subsequently, intravenous methylprednisolone was administered to patient. Patient showed marked response to the steroid given. At the time of discharge, twenty-seven days later, patient had recovered from most of the neuropsychiatric sequelae; but still required assistance during ambulation. In conclusion, correction of electrolyte imbalances should be done in a more judicious manner. Prudent corrections of electrolyte alterations could have possibly prevented the onset of ODS and its’ devastating neuropsychiatric sequelae in this patient. Please click PDF below to download the full paper.
AN EPIDEMIOLOGICAL STUDY TO ASSESS MORBIDITY PROFILE AMONG GERIATRIC POPULATION IN DISTRICT DEHRADUN.

Introduction: The world is ageing, it is natural and inevitable. The risk of having at least one chronic disease, such as hypertension, diabetes, arthritis, cancers increases with age, this is not so much a function of chronological age per se but a reflection of the life-long accumulation of risk factors. Further, obesity increases the risk of numerous non communicable diseases viz. cardiovascular diseases, diabetes and hypertension etc. So study was planned to find out the morbidity profile of geriatric population (>60years) in District Dehradun. Methodology: A cross sectional study was conducted in Doiwala Block (rural) & Dalanwala (Urban) area of District Dehradun of Uttarakhand Dehradun (Uttarakhand) to assess the health status of elderly population during April - June 2010. Study had attempted to include all the households and residents of the study areas who were above 60 years of age. Results: Working geriatric study group involved in livelihood were found to be less morbid as compared to retired or Homemaker (i.e. housewives). Among non-working group higher prevalence of non communicable disease viz CVS (16.4%), hypertension (38.6%), diabetes (17.7%), arthritis (21.2%), asthma (7.7%), cataract (17.5%) & BPH (12.2%) was observed as compared to working group. Morbidities were more common among obese viz. hypertension (39.1%), CVS diseases (26.1%), diabetes (10.0%) and high risk WHR (47.8%). Hypertension (I & II) is more common (36.1%) amongst geriatric person with BMI of more than 25 and above as compared to BMI less than 25 (25%). Conclusion: Present study observed higher prevalence of cardiovascular morbidity, arthritis & cataract among non working group as compared to working group. Present study also shows higher BMI also increases the high risk factors for non communicable disease.
Programming and Problem Solving: Will Two Languages Do it?

High school students learning a second programming language, students learning a first language, and students receiving no programming instruction were compared to determine whether instruction in a second language helps produce transfer of problem-solving skills. Approximately half of each programming group received a two-week problem-solving intervention. Six problem-solving measures were used: use of re-useable procedures, solution of problems by analogy, solution of Hanoi-like problems (recursive procedures), creative problem solving, use of the biconditional, and debugging. Students receiving the problem-solving intervention in their first programming language course improved (p < .05) on the use of the biconditional and on creative problem solving. Students learning a second language were significantly better at debugging (p < .05) than those learning only a first language. Suggestions are made for further research.
Threshold gain difference requirements for nearly single-longitudinal-mode lasers

The performance implications of mode partition fluctuations in nearly single longitudinal mode lasers are examined in a comprehensive manner using a technique which utilizes a simulation-based method to determine the partitioning statistics and a formula-based method to evaluate the bit error ratio. Utilizing a truncated pulse train, Gauss quadrature rule method, it is possible to accommodate many features unique to the problem of assessing the performance implications of mode partitioning. For several systems, the required value of the threshold gain difference between the lasing mode and the dominant side mode is determined. For 2.4 Gb/s NRZ modulation, the threshold gain difference requirement increases from 3 cm/sup -1/ to 7 cm/sup -1/ as the bias current of the laser decreases from 1.1 to 0.9 times the laser threshold current. For 4.8 Gb/s NRZ modulation, the threshold gain difference requirement increases from 5/sup -1/ to 8 cm/sup -1/ as the bias current of the laser decreases from 1.2 to 1.01 times the laser threshold current. The threshold gain difference requirement has been found to be more stringent for the RZ encoding format. <<ETX>>
A new differential LNA topology for wireless applications

In this paper a new topology of differential low noise amplifier for wireless applications is presented. This solution allows a drastic area reduction, with respect to traditional emitter coupled topology, since it makes it possible to achieve integrated matching at the input by using only down-bond wiring. In this way no integrated inductors are needed. As shown by simulations, an increased linearity range can also be obtained, without impairing the noise figure. As an example of this new solution, a LNA has been designed for 2.44 GHz frequency operation. The main characteristics of this amplifier are: a noise figure of 1.56 dB, a voltage gain of 19.5 dB, an input impedance of 50 /spl Omega/, an input-referred 3/sup rd/ intercept point of -7.25 dBm and a dissipated power equal to 19 mW.
Performance and haemobiochemical profile of broilers fed on supplementation of shatavari (Asparagus racemosus willd.) root powder

An experiment was conducted to asses the effect of shatavari (Asparagus racemosus witld.) root powder on the performance of broilers. Eighty day old chicks were randomly distributed in four treatments of two replications in each and reared up to 6 weeks of age on standard managemental conditions. The root powder of shatavari was added over the basal ration at 0.5% level (T), 1% level (T), 1.5% level (T.), where as the T, was control basal ration having CP 22% and ME 2900 Kcal/kg of feed. The average body weight sat 6th week of age for T1, T2, T3 and T4 were 1104.00 ± 61.96, 1256.50 ± 45.84, 1514.50 ± 33.28 and 1560.50 ± 38.43 g, respectively. The body weight gain and feed efficiency varied significantly (P<0.01) between the different treatments and found to be better with increasing level of shatavari root powder. The DM and CP digestibility for T1, T2, T3, T4 was 64.77 ± 0.67 and 55.45 ± 1.76, 65.59 ± 0.53 and 59.16 ± 1.62, 67.07 ± 0.26 and 60.12 ± 1.27, 67.17 ± 0.87 and 60.52 ± 1.25 per cent, respectively. The birds in all the treatments were in positive nitrogen balance. The blood biochemical profile revealed the significant (P<0.01) rise in haemoglobin, serum total protein and globulin. It was concluded that the supplementation of shatavari root powder has beneficial effects on body weight and feed conversion efficiency and also improves the general health status of birds.
Algunos Aspectos Relacionados con el Control Administrativo y Contable de la Renta de los Esclavos Enviados a Hispanoamérica

RESUMEN Este es el primer trabajo, de una serie que queremos dedicar al estudio y análisis de los instrumentos de control administrativo y contable de la trata de esclavos enviados a Hispanoamérica durante un período de cuatro siglos, que comienza con el descubrimiento de América en 1492 y termina con la abolición total de la esclavitud en 1888. Se trata de un tema que ha sido estudiado desde diferentes ópticas, principalmente económicas, pero que, desde una perspectiva contable, aún no ha sido tratado ni investigado. Nosotros, en este primer trabajo, utilizando básicamente fuentes primarias que se van citando a lo largo de su desarrollo, únicamente queremos demostrar que este negocio, en España, desde sus comienzos, fue sometido a un riguroso control administrativo y contable, favorecido por el importante desarrollo que las prácticas y técnicas contables habían experimentado en esa época. Época que, para este primer trabajo, hemos limitado, de los cinco períodos en que puede ser dividida la historia de este comercio en las posesiones españolas en América, a los dos primeros que se desarrollan entre 1492 y 1595.
Eating disorders in adult women: biopsychosocial, developmental, and clinical considerations

Research and clinical practice indicate that increasing numbers of adult women are suffering from both clinical and subclinical eating disorders and are now seeking treatment. The unique needs and experiences of this population bear examination through the lens of female adult development. The rapid increase in eating disorders, the ongoing gender disparity, and the complex realities of female biology suggest that this evaluation will be best informed by a biopsychosocial perspective. Developmental transitions including marriage, divorce, pregnancies, parenting, menopause, and the ageing process all create risk in an era that promotes weight loss, thinness, and a youthful appearance as the ultimate signs of success for women. Globalisation has contributed to the emergence of eating disorders in diverse countries and cultures. Consequently, all primary mental health and medical providers must understand the risk factors, signs, and symptoms of adult eating disorders, as well as the effect of environmental stressors on these risk factors in producing illness. This patient population requires unique treatment options, especially outpatient programmes and psychoeducation and support for their families and life partners, in order to foster recovery while maintaining their roles in their families, workplaces, and communities.
ASSESSMENT OF DIFFERENT TEACHING AIDS AND TEACHING METHODS FOR THE BETTER PERCEPTION OF BIOCHEMISTRY BY 1ST MBBS STUDENTS

: BACKGROUND : Medical students during their first year of MBBS course, find Biochemistry difficult and volatile. In this regard, we studied the feedback from students about the effectiveness of prevailing teaching aids and methods, so that best teaching aid and method can be adopted to improve their academic performance. METHODS: This study comprises of total 117 students of 1st MBBS course, who have completed the 2 nd semester of academic year 2011-12. Irrespective of the teacher and topic, the students were asked to grade the teaching aids and methods that were used to teach Biochemistry for the period of 10 months (from August 2011 to May 2012). RESULTS : In our study high Satisfaction Index (SI) was noticed for combination method of teaching aid (blackboard+ PowerPoint*(PPT)) and teaching preceded and followed by asking questions + assessment + tutorials, teaching method. CONCLUSION : This observation may probably be due to the fact that, inherent deficiency of each teaching aid is compensated by the other. With regard to, teaching method the combination of teaching methods is more effective when compared to didactic lectures.
Prevalence of Vitamin D deficiency in a multiracial female population in KwaZulu-Natal province, South Africa

Objective: Vitamin D deficiency is a global health issue affecting many countries, especially those in temperate climates. The aim of this study was to determine the prevalence of Vitamin D deficiency and level of 25-hydroxyvitamin D [25(OH)D] in females categorised by age and race. Methods: The study was performed between January 2015 and January 2016. This study consisted of 1 976 females stratified by age into < 18, reproductive age (18–45) and > 45 years. Demographic variables were recorded and serum 25(OH)D levels measured by chemiluminescent emission. Results: The predictors of lower 25(OH)D levels included age and race, (p < 0.0001 for each predictor). Approximately 46% of females had < 20 ng/ml 25(OH)D level, the majority of whom were Indian (35%). The 25(OH)D level varied by race (White 27.33 ng/ml; Black 23.43 ng/ml and Indian 15.05 ng/ml; p < 0.0001). In the <18-year age category, White and Black women had significantly higher 25(OH)D levels when compared with Indian women (38.25 ng/ml vs. 37.51 ng/ml vs. 13.68 ng/ml respectively; p < 0.0001). Similarly, in the reproductive age category (18–45 years); White (27.63 ng/ml) and Black (20.93 ng/ml) women had a significantly higher 25(OH)D level compared with Indian (13.15 ng/ml) women (p < 0.0001). Moreover, similar data were observed within the > 45-year age category, where the White and Black women had higher 25(OH)D levels compared with Indian women (25.46 ng/ml vs. 22.73 ng/ml vs. 17.04 ng/ml; p < 0.0001) respectively. Irrespective of age category, severe vitamin D deficiency was highest amongst Indian females. Conclusion: This study demonstrates a significant difference in 25(OH)D concentration in healthy females living in Durban, with Indians presenting with the highest vitamin D deficiency. These findings clearly highlight the need for a policy on vitamin D supplementation and/or fortification of food. Further studies are under way to assess the genetic predisposition of women to vitamin D deficiency.
Childbearing and maternity leave in residency: determinants and well-being outcomes

Purpose To characterise determinants of resident maternity leave and their effect on maternal and infant well-being. Among non-parents, to identify factors that influence the decision to delay childbearing Study design In 2016, a survey was sent to female residents at a large academic medical centre on their experiences with maternity leave, the impact of personal and programme factors on length of leave, reasons for delaying childbearing and measures of well-being. Results Forty-four percent (214/481) of residents responded. Fifty (23%) residents were parents, and 25 (12%) took maternity leave during training. The average maternity leave length was 8.4 weeks and did not differ across programme type, size or programme director gender but was longer for programmes with fewer women than men. The most common self-reported determinant of leave was financial. Residents with >8 weeks of leave were less likely to have postpartum depression or burnout and more likely to breastfeed longer, perceive support from colleagues and programme directors, and be satisfied with resident parenthood. Among 104 non-parents who were married or partnered, 84 (81%) were delaying childbearing, citing busy work schedules, concern for burdening colleagues and finances. Conclusions This study suggests that multiple aspects of resident wellbeing are associated with longer maternity leaves, yet finances and professional relationships hinder length of leave and lead to delayed childbearing. These issues could be addressed at a programme level with clear policies describing how work is redistributed during parental leave and at an institutional and state level through provision of paid family leave.
The use of Cryptography in Network Security

Network Security is the most vital component in information security because it is responsible for securing all information passed through networked computers. Network Security refers to all hardware and software functions, characteristics, features, operational procedures, accountability, measures, access control, and administrative and management policy required to provide an acceptable level of protection for Hardware and Software, and information in a network. Only one particular element underlies many of the security mechanisms in use: Cryptographic techniques; hence our focus is on this area Cryptography. Cryptography is an emerging technology, which is important for network security. Research on cryptography is still in its developing stages and a considerable research effort is still required for secured communication.
La culture et le recours aux IAS/IFRS

Cet article essaie d’identifier empiriquement les facteurs culturels qui incitent les pays a choisir les IAS/IFRS. En premier temps, nous allons presenter une revue de la litterature liee aux facteurs ayant un impact sur le choix des systemes comptables. Ensuite, nous allons determiner les facteurs culturels motivant differents pays que nous allons classer selon leurs strategies de normalisation. Les resultats montrent que l’implantation des Big 4 et l’appartenance d’un pays au continent europeen et a l’Amerique du Nord encouragent le recours aux IAS/ IFRS. Mais, la colonisation et la religion chretienne ne favorisent que le passage d’une strategie de convergence vers une strategie d’adoption des normes internationales. Mots-cles : Normalisation comptable, Culture, Convergence, Adoption, IASB, IAS/IFRS.
Distribution of Oral Manifestation among HIV Patients Attending Art Centers in Chennai

Oral health forms an important aspect of overall general health. Ranging from minor infections to several chronic diseases, oral health can be a first indicator to identify health problems. HIV infection causes progressive deficiency in the immune system leading to many opportunistic infections and a wide range of oral manifestations. Oral manifestations have found a place in many classifications and staging related to HIV infection. Many earlier studies on oral manifestation of HIV have been based on western population. Hence a study highlighting the distribution of oral manifestation among HIV patients under ART have been undertaken involving South Indian population.
ORIGINAL ARTICLE Analysis of CD16 þ CD56 dim NK cells from CLL patients: evidence supporting a therapeutic strategy with optimized anti-CD20 monoclonal antibodies

Although anti-CD20 monoclonal antibodies (mAbs) show promise for the treatment of chronic lymphocytic leukemia (CLL), the success of the anti-CD20 mAb rituximab in CLL treatment has been limited. Novel anti-CD20 mAbs with more potent cytotoxic activity have recently been engineered, but so far most have only been tested in vitro with natural killer (NK) cells from healthy donors. Because it is still unclear whether these optimized cytotoxic mAbs will improve NK-cell killing of tumor cells in CLL patients, we characterized the relevant phenotypic and functional features of NK cells from CLL patients in detail. Expression of inhibitory and activating NK-cell receptors and of Fc gamma receptor IIIA (FccRIIIA) is well preserved in CD16 þ CD56 dim cytotoxic NK cells from these patients, independently of disease progression. These cells are fully functional following cytokine stimulation. In addition, the FccRIIIA-optimized LFB-R603 anti-CD20 mAb mediates 100 times greater antibody-dependent cell-mediated cytotoxicity by NK cells from CLL patients and healthy donors than rituximab. Enhanced degranulation against autologous B-CLL cells is observed at lower concentrations of LFB-R603 than rituximab, regardless of CLL prognostic factors. These findings strongly justify further clinical development of anti-CD20 mAbs optimized for FccR engagement in CLL patients.
Quantum Systems, Channels, Information: A Mathematical Introduction

The subject of this book is theory of quantum system presented from information science perspective. The central role is played by the concept of quantum channel and its entropic and information characteristics. Quantum information theory gives a key to understanding elusive phenomena of quantum world and provides a background for development of experimental techniques that enable measuring and manipulation of individual quantum systems. This is important for the new efficient applications such as quantum computing, communication and cryptography. Research in the field of quantum informatics, including quantum information theory, is in progress in leading scientific centers throughout the world. This book gives an accessible, albeit mathematically rigorous and self-contained introduction to quantum information theory, starting from primary structures and leading to fundamental results and to exiting open problems.
Phase 1 study of JNJ-42756493, a pan-fibroblast growth factor receptor (FGFR) inhibitor, in patients with advanced solid tumors.

2501 Background: JNJ-42756493 is an orally bioavailable FGFR 1, 2, 3 and 4 inhibitor with nanomolar antitumor activity in cell lines and in vivo models with FGFR pathway aberration. Methods: This first in human study consists of 3 parts: dose escalation part 1to determine the recommended phase 2 dose (RP2D), dose confirmation part 2 with focus on pharmacodynamic effects, and dose expansion part 3 to evaluate the antitumor activity in selected solid tumors with FGFR gene amplification, mutation or translocation at the RP2D. Biomarkers include tumor tissue genomic profiling, skin/tumor biopsies and soluble serum markers. Toxicity is graded with CTCAE-4 and antitumor activity is assessed using RECIST 1.1. Results: As of 27 January 2014, 37 patients have been treated at 6 dose levels (0.5, 2, 4, 6, 9 and 12 mg daily continuously) in part 1. Most common (≥ 20% of patients) adverse events (AEs) were hyperphosphatemia (60%), asthenia (46%), dry mouth (30%), constipation (27%), abdominal pain (22%), stomatitis (2.
Entre science et patrie : Lecture du régionalisme de Paul Vidal de la Blache

Paul Vidal de la Blache (1845-1918) fut a la fois soucieux de comprendre la place du facteur politique dans la dynamique geographique et de donner, en France, une audience politique a la discipline geographique. Cette double preoccupation est particulierement manifeste dans le militantisme regionaliste de Vidal. L'article cherche a expliquer pourquoi et a quelles conditions geographie et engagement politique s'influencent mutuellement dans le regionalisme vidalien.
Song and music in the Pauline epistles: Paul’s utilisation of Jewish, Roman and Greek musical traditions to encourage the early Christian communities to praise God

This article presents an exegetical investigation of several Pauline texts in which he encourages early Christian communities to praise God with song and music. Paul encourages the congregation in Rome to praise God in unity. The Colossians and Ephesians are exhorted to sing in order to instruct and to admonish one another to glorify God. Furthermore Paul remarks on hymn singing in the Corinthian congregation. In this article it is indicated that influences from Jewish, Roman and Greek cultures in these different communities are probable. Each of these three cultures had a long musical tradition and thus the content and typical features of their musical traditions are investigated. Furthermore, the issue whether Paul utilised features from these musical traditions to encourage the early Christians to praise God with song and music is also explored. The article concludes that insight in these features results in a better understanding of Paul’s teaching with regard to the use of song and music in Christian worship – also for today.