Miracle-dz/UniFAR-FTUs huggingface dataset:
Resveratrol opposite effects on rat tissue lipoperoxidation: pro-oxidant during day-time and antioxidant at night

Abstract We investigated the dosing-time dependency of acute resveratrol administration on lipoperoxidation level found in the heart, liver and kidney of male rats synchronized with a 12-h dark-light cycle. Resveratrol was administered by the i.p. route at the middle of the dark (6 h after dark onset, HADO) or light span (18 HADO) and thiobarbituric acid reactive species (TBARS) measured 4 h later at 10 and 22 HADO, respectively. Basal TBARS levels in the three organs were higher during the night span when compared to day span. Resveratrol effect on tissues TBARS was also dosing-time dependent. When administered during the dark phase, resveratrol decreased TBARS levels whereas at the light span, the polyphenol increased TBARS in the three organs. Resveratrol behaved as an antioxidant during the dark span and as a pro-oxidant during the light span. These data suggested a day/night rhythm in basal lipoperoxidation and in resveratrol antioxidant effect.
Activin A Plasma Levels at Birth: An Index of Fetal Hypoxia in Preterm Newborn

Activin-A is a growth factor involved in cell growth and differentiation, neuronal survival, early embrionic development and erythropoiesis. Hypoxemia is a specific trigger for increasing activin-A in fetal lamb circulation. We tested the hypothesis that fetal hypoxia induces activin-A secretion in preterm newborn infants. Fifty newborn infants with gestational ages ranging from 26 to 36 wk were enrolled in a prospective study performed at the Pediatrics, Obstetrics and Reproductive Medicine Department, University of Siena, Italy. Heparinized blood samples were obtained from the umbilical vein after cord clamping, immediately after delivery. Activin A, hypoxanthine (Hx), xanthine (Xa) plasma levels and absolute nucleated red blood cell (NRBC) count were measured. Activin-A levels (p < 0.0001) and NRBC (p < 0.0001) were significantly higher in hypoxic than in non hypoxic preterm newborns. Cord activin A levels were significantly related with Hx (τa=0.64, τb=0.64, p < 0.0001) and Xa (τa=0.56, τb=0.57, p < 0.0001) levels, NRBC ((τa=-0.45, τb=-0.46, p < 0.0001) count; pH (τa=-0.47, τb=-0.48, p < 0.0001) and base deficit (τa=-0.36, τb=0.-0.36, p = 0.0002). Preterm newborns with signs of perinatal hypoxia at birth have increased activin-A levels, suggesting that activin-A may reflect indirectly intrauterine hypoxia.
THE IMPACT OF TRAINING ON CRISIS MANAGEMENT : HUMAN RESOURCE DEVELOPMENT MEDIATIONVARIABLE USING (SEM)

The study aimed to verify the impact model validity of Human Resource Trainingon Crisis Management. This model included an (external factor)Human Resource Training, and an (internal factor)Crisis Management. The study also aimed to verify the true forecasting of the model Human Resource Developmentas a (Mediation)variable between the Human Resource Training and Crisis Management. For achieving these objectives, the study used a quantitative approach to analyzing the data including the structural equation modeling(Confirmatory Factor AnalysisCFA)(AMOS,21) to test the validity of the research model. The study reached to a set of results, from which the most important result was that the Human Resource Training had a positive impact on Crisis Management. The study also reached the existence of a positive impact of Human Resource Trainingmodel on Crisis Managementthrough its positive impact on the Development of human resources, which was as Mediation variable.
Global asymptotics of the Meixner polynomials

Using the steepest descent method for oscillatory Riemann-Hilbert problems introduced by Deift and Zhou (Ann. Math. 137 (1993), 295-368), we derive asymptotic formulas for the Meixner polynomials in two regions of the complex plane separated by the boundary of a rectangle. The asymptotic formula on the boundary of the rectangle is obtained by taking limits from either inside or outside. Our results agree with the ones obtained earlier for z on the positive real line by using the steepest descent method for integrals (Constr. Approx. 14 (1998), 113-150).
Evaluation of a social marketing campaign to support Mexico City's comprehensive smoke-free law.

OBJECTIVES We aimed to assess the level of awareness and impact of a social marketing campaign to promote Mexico City's 2008 comprehensive smoke-free law. METHODS Four months after the smoke-free law was implemented but before the campaign launch, we collected data from a population-based, random sample of 961 inhabitants of Mexico City. We analyzed data from 786 respondents who completed follow-up at the end of the campaign to determine campaign exposure and the association between campaign exposure and changes in campaign-targeted knowledge and attitudes. RESULTS Recall of any of the 5 campaign materials was 69%, with a uniform distribution of exposure to 1, 2, and 3 or more campaign materials (25%, 25%, and 19%, respectively). Exposure to a greater number of campaign materials was associated in a monotonic relation with campaign-targeted knowledge of ammonia and arsenic in cigarette smoke. In models assessing support for, perceived benefits of, and perceived right to smoke-free places, campaign exposure accounted for a positive change in half of the indicators within each of these domains. CONCLUSIONS Social marketing campaigns can reinforce knowledge and attitudes that favor smoke-free laws, thereby helping to establish smoke-free norms.
DEAD ZONE COMPENSATION IN PNEUMATIC SERVO SYSTEMS

This paper presents an approach for dead zone compensation in pneumatic position servo systems. The dead zone is an inherent nonlinearity in pneumatic servovalves, where for a range of input control values, the valve gives no output flow. Although pneumatic actuators are very common in industry, they have limitations in servo pneumatic applications that are caused by typical non-linearities of Pneumatics, as servovalve dead zone, air flow-pressure relationship through valve orifice, air compressibility and friction effects between contact surfaces in actuator seals. The servovalve dead zone compensation is easy to implement and brings important results in trajectory tracking control applications, according to depicted in this paper. A mathematical model to dead zone in pneumatic servovalves is presented, followed by the method used to compensation, that is made with the addition of an inverse dead zone function in control system. Tests are carried out to validation using controllers with and without dead zone compensation to comparison. Experimental results show that dead zone compensation improves controller performance. Dead zone compensation is easy to carry out, turns possible use simpler controllers in control and is an important procedure to develop controllers to application of Pneumatics in Robotics.
Methionine Sulfoxide Reductase A (MsrA) Deficiency Affects the Survival of Mycobacterium smegmatis within Macrophages

ABSTRACT Methionine sulfoxide reductase A (MsrA) is an antioxidant repair enzyme which reduces oxidized methionine to methionine. Since oxidation of methionine in proteins impairs their function, an absence of MsrA leads to abnormalities in different organisms, including alterations in the adherence patterns and in vivo survival of certain pathogenic bacteria. To understand the role of MsrA in intracellular survival of bacteria, we disrupted the gene encoding MsrA in Mycobacterium smegmatis through homologous recombination. The msrA mutant strain of M. smegmatis exhibited significantly reduced intracellular survival in murine J774A.1 macrophages compared to the survival of its wild-type counterpart. Furthermore, immunofluorescence and immnunoblotting of phagosomes containing M. smegmatis strains revealed that the phagosomes with the msrA mutant strain acquired both p67phox of phagocyte NADPH oxidase and inducible nitric oxide synthase much earlier than the phagosomes with the wild-type strain. In addition, the msrA mutant strain of M. smegmatis was observed to be more sensitive to hydroperoxides than the wild-type strain was in vitro. These results suggest that MsrA plays an important role in both extracellular and intracellular survival of M. smegmatis.
Users’ Perceptions on Internet Financial Reporting: Empirical Evidence from Bangladesh

In the age of digitalization, Intemet Financial Reporting (IFR) brings a revolutionary & dramatic change in information availability to the extemal users. The lntemet technology enables companies to make continuous disclosure of corporate information which offers several significant benefits to the users. The rnotivation of this research is to measure the perception of users regarding the benefits and problems of intemet t'inancial reporting in the context of Bangiadesh. We have seiected the 133 respondents by random sampling. The respondents of our study include students. teachers, bankers, businessman and so on. The researchers have identified fourteen most important benef'lts that IFR can offer to the users. Among the benefits of IFR, the most mentionable are - easily communicable, conveniently accessible, provide trmely information. comtbrtable to use and inexpensive. This study rer,ealed t'erv problems of IFR also-difficulty in differentiation between unaudited and audited items, costly IFR printing and difticulty in differentiation between mandatory and non-mandatory information. Finally, we have made a lactor analysis with the fourteen items (the benefits of IFR). This resulted in six factors rvhich expiain 63.43Va of the total variance. This research is very much relevant in the recent digitalization strategy of Bangladesh and will contribute in the existing academic literature as this is the first documented attempt of this kind in Bangladesh. Abstract In the age of digitalization, Internet Financial Reporting (IFR) brings a revolutionary & dramatic change in information availability to the external users. The Internet technology enables companies to make continuous disclosure of corporate information which offers several significant benefits to the users. The motivation of this research is to measure the perception of users regarding the benefits and problems of internet financial reporting in the context of Bangladesh. We have selected the 133 respondents by random sampling. The respondents of our study include students, teachers, bankers, businessman and so on. The researchers have identified fourteen most important benefits that IFR can offer to the users. Among the benefits of IFR, the most mentionable are – easily communicable, conveniently accessible, provide timely information, comfortable to use and inexpensive. This study revealed few problems of IFR also — difficulty in differentiation between unaudited and audited items, costly IFR printing and difficulty in differentiation between mandatory and non-mandatory information. Finally, we have made a factor analysis with the fourteen items (the benefits of IFR). This resulted in six factors which explain 63.43% of the total variance. This research is very much relevant in the recent digitalization strategy of Bangladesh and will contribute in the existing academic literature as this is the first documented attempt of this kind in Bangladesh.
A 5×5 model of the six phase squirrel cage induction machine (6PIM) in faulted condition

Faulted mode condition for multiphase induction machines means that one or more phases of supply are removed. Modelling the machine under these conditions presents many questions for squirrel cage topology about consideration of the fictive rotor winding. In this way, this paper presents a comparison between two assumptions on considering the modeling of the six phase induction machine with squirrel cage. The first assumption is based on the consideration that the fictive rotor winding is composed of six balanced dimension while the second one is based on the existence of five balanced rotor windings for the rotor. The speed spectrums obtained in simulation with the two models are compared with the experimental one to define the most suitable model for 6PIM in faulted condition.
Association of tissue mast cells and skin tumors.

The evident relationship between mast cells and tumors of various tissues and organs is a fascinating enigma. The association of mast cells with naturally occurring skin tumors, a subject which has not received much previous attention, was examined in the present study. Material and Methods Ten % aqueous formalin-fixed specimens of human skin which embraced both the tumor and the contiguous tissue (the term "contiguous tissue" as used in this paper refers to the dermal, but not the epidermal, tissue adjoining the tumors), the diagnosis having been made on sections stained with hematoxylin and eosin, were sectioned and treated with 0.01% toluidine blue.1We have found aqueous formalin to be a serviceable fixative for mast cells in human skin despite objections which have sometimes been raised to its use.1 The types and numbers of tumors examined were as follows: The mast cells in each tumor and in the contiguous
Volumetric Assessment of Glioma Removal by Intraoperative High-field Magnetic Resonance Imaging

OBJECTIVE:To investigate the contribution of high-field intraoperative magnetic resonance imaging (iMRI) for further reduction of tumor volume in glioma surgery. METHODS:From April 2002 to June 2003, 182 neurosurgical procedures were performed with a 1.5-T magnetic resonance system. Among patients who underwent these procedures, 47 patients with gliomas (14 with World Health Organization Grade I or II glioma, and 33 with World Health Organization Grade III or IV glioma) who underwent craniotomy were investigated retrospectively. Completeness of tumor resection and volumetric analysis were assessed with intraoperative imaging data. RESULTS:Surgical procedures were influenced by iMRI in 36.2% of operations, and surgery was continued to remove residual tumor. Additional further resection significantly reduced the percentage of final tumor volume compared with first iMRI scan (6.9% ± 10.3% versus 21.4% ± 13.8%; P < 0.001). Percentages of final tumor volume also were significantly reduced in both low-grade (10.3% ± 11.5% versus 25.8% ± 16.3%; P < 0.05) and high-grade gliomas (5.4% ± 9.9% versus 19.5% ± 13.0%; P < 0.001). Complete resection was achieved finally in 36.2% of all patients (low-grade, 57.1%; high-grade, 27.3%). Among the 17 patients in whom complete tumor resection was achieved, 7 complete resections (41.2%) were attributable to further tumor removal after iMRI. We did not encounter unexpected events attributable to high-field iMRI, and standard neurosurgical equipment could be used safely. CONCLUSION:Despite extended resections, introduction of high-field iMRI in conjunction with functional navigation did not translate into an increased risk of postoperative deficits. The use of high-field iMRI increased radicality in glioma surgery without additional morbidity.
Anchoring in Financial Decision-Making: Evidence from the Field

This paper analyzes 12,596 wagering decisions of 6,064 contestants in the US game show Jeopardy! , focusing on the anchoring phenomenon in financial decision-making. We find that contestants anchor heavily on the initial dollar value of a clue in their wagering decision, even though there exists no rational reason to do so. More than half of all wagers occur within $500 of the initial dollar value, although the maximum possible wagering value averages $5,914. This anchoring phenomenon remains statistically significant on the one percent level, even after controlling for scores, clue category, time trends, and player-fixed effects. When exploiting within-player variation only and implicitly controlling for a host of individual behavioral attitudes and preferences, raising the anchoring amount by 10 percent translates to an increase of 3.1 percent in the wager. In terms of magnitude, anchoring is marginally more pronounced for women with an elasticity of 0.34 versus 0.28 for males. Finally, this paper is among the first to investigate anchoring among children and teenagers. We find little evidence for anchoring among children under the age of 13, but the effect begins to emerge for teenagers and further manifests itself among college students. Overall, our findings suggest anchoring plays a substantial role in financial decision-making under pressure.
A complex of YlbF, YmcA and YaaT regulates sporulation, competence and biofilm formation by accelerating the phosphorylation of Spo0A

Bacillus subtilis has adopted a bet‐hedging strategy to ensure survival in changing environments. From a clonal population, numerous sub‐populations can emerge, expressing different sets of genes that govern the developmental processes of sporulation, competence and biofilm formation. The master transcriptional regulator Spo0A controls the entry into all three fates and the production of the phosphorylated active form of Spo0A is precisely regulated via a phosphorelay, involving at least four proteins. Two proteins, YmcA and YlbF were previously shown to play an unidentified role in the regulation of biofilm formation, and in addition, YlbF was shown to regulate competence and sporulation. Using an unbiased proteomics screen, we demonstrate that YmcA and YlbF interact with a third protein, YaaT to form a tripartite complex. We show that all three proteins are required for proper establishment of the three above‐mentioned developmental states. We show that the complex regulates the activity of Spo0A in vivo and, using in vitro reconstitution experiments, determine that they stimulate the phosphorelay, probably by interacting with Spo0F and Spo0B. We propose that the YmcA–YlbF–YaaT ternary complex is required to increase Spo0A~P levels above the thresholds needed to induce development.
Human herpesvirus 8 infection in hemodialysis patients.

BACKGROUND The aim of the present study was to evaluate human herpesvirus 8 (HHV-8) seroprevalence in Greek hemodialysis patients. Patterns of change in HHV-8 serostatus (seroconversions and seroreversions) over time were also evaluated. METHODS Serum samples obtained from a cohort of 485 Greek hemodialysis patients were tested for antibodies to HHV-8 by whole virus lysate enzyme-linked immunosorbent assay, and reactive samples were confirmed by means of the orf-73 enzyme-linked immunosorbent assay. HHV-8 seroprevalence at study entry and the incidence of seroreversions and seroconversions per 100 person-years were estimated. RESULTS The prevalence of HHV-8 antibodies in Greek hemodialysis patients at enrollment was 7.2%. No univariate associations were established between HHV-8 serostatus and patients' characteristics. Incidences of seroreversions and seroconversions were 16.4/100 person-years (95% confidence interval, 7.1 to 32.3) and 0.28/100 person-years (95% confidence interval, 0.03 to 1.02), respectively. Patients 50 years and younger had an increased probability for seroreversion to HHV-8 antibodies than patients older than 50 years (log-rank test, P = 0.018). CONCLUSION We observed a fair number of seroreversions and a low incidence of seroconversion to HHV-8 infection in hemodialysis patients in Greece. Our data provide indirect evidence that HHV-8 transmission in the hemodialysis setting is uncommon.
The Evaluation, Analysis, and Management of the Business Outsourcing Process

A critical question faced by industrial leaders is “which aspects of our value chain should we perform internal to our organization and which aspects should we source externally? ” This demarcation of firm boundaries has been increasingly studied from the perspective of outsourcing. Outsourcing can be defined as the complete transfer of a business process that has been traditionally operated and managed internally to an independently owned external service provider. Outsourcing can further be conceptualized as a process which begins with developing a strategic and financial business case for outsourcing, followed by implementing the external sourcing model, and ultimately managing the relationship with the provider(s). Despite the surging popularity of outsourcing in practice, evidence from multiple sources suggests that a surprising percentage of outsourcing efforts fail to realize performance expectations. Given these observations, the research objective was to identify the salient management practices throughout the outsourcing process that drive performance. The research objective was empirically addressed using a cross-sectional survey to collect detailed data on 198 outsourcing initiatives representing a diverse set of outsourcing experiences. Factor analysis was used to establish the validity and reliability of the measurement model, which includes five constructs representing aspects of the
Lateral Hostilities Among Nurses Employed in Intensive Care Units, Emergency Departments, Operating Rooms, and Emergency Medical Services: A National Survey in Italy

Background:Lateral hostilities (LHs) are “nasty, unkind, aggressive behavior between colleagues working at comparable organizational levels. ” When LHs occur “at least once a week for a period of not less than 6 months,” they become “bullying. ” The frequency of lateral violence in health care literature varies from 5.7% to 65%. Objectives:The aim of this study was to explore the extent of LH and the effects on the quality of lives of Italian nurses working in prehospital emergency medical system, emergency department, intensive care unit, and operating rooms. Methods:A descriptive study was conducted through an online survey in the Web site of the National Italian Association of Critical Care Nurses (ANIARTI). Results:A total of 1504 nurses filled up the questionnaire, with 1202 valid data entries (79.9%). Of this group, 739 (61.5%) were women and 951 (79.1%) had experienced some form of LH at least once in the last 12 months, whereas 269 (22.4%) felt to be victims of bullying. The number of transfers to other departments/services due to LH was 43 cases (3.6%), and 829 (69%) experienced psychophysical disorders attributed to LH experienced in the span of the year. Discussion:Lateral hostility is a frequent occurrence that calls for implementation of management policies to achieving an overall improvement of the work environment climate.
The Impact of Trust in the News Media on Online News Consumption and Participation

Trust has long been considered an important factor that influences people’s relationship with news. However, the increase in the volume of information available online, together with the emergence of new tools and services that act as intermediaries and enable interactivity around the news, may have changed this relationship. Using Reuters Institute Digital News Report survey data (N = 21,524), this study explores the impact of individual trust in the news media on source preferences and online news participation behaviour, in particular sharing and commenting, across 11 countries. The results show that those with low levels of trust tend to prefer non-mainstream news sources like social media, blogs, and digital-born providers, and are more likely to engage in various forms of online news participation. These associations tend to be strongest in northern European countries, but are weaker elsewhere. Seeking alternative views and attempting to validate the credibility of news may be among the motivations behind these associations.