Miracle-dz/UniFAR-FTUs huggingface dataset:
Averaging metric phylogenetic trees

This paper investigates the computational geometry relevant to calculations of the Frechet mean and variance for probability distributions on the phylogenetic tree space of Billera, Holmes and Vogtmann, using the theory of probability measures on spaces of nonpositive curvature developed by Sturm. We show that the combinatorics of geodesics with a specified fixed endpoint in tree space are determined by the location of the varying endpoint in a certain polyhedral subdivision of tree space. The variance function associated to a finite subset of tree space is continuously differentiable within each cell of the corresponding subdivision. We use this subdivision to establish two iterative methods for producing sequences that converge to the Frechet mean: one based on Sturm's Law of Large Numbers, and another based on descent algorithms for finding optima of smooth functions on convex polyhedra. We present properties and biological applications of Frechet means and extend our main results to more general globally nonpositively curved spaces composed of Euclidean orthants.
Inadmissible Testimony, Instructions to Disregard, and the Jury: Substantive Versus Procedural Considerations

The present study tested the hypothesis that jurors comply selectively with instructions to disregard inadmissible evidence. A total of 81 mock jurors read a murder trial summary in which a wiretap was ruled admissible, inadmissible because it was not reliable, or inadmissible because it was illegally obtained (there was also a no-wiretap control group). As predicted, participants were more likely to vote guilty and interpret subsequent evidence as more incriminating in the admissible and inadmissible/due-process conditions than in the admissible/unreliable and control groups. These results suggest that jurors are influenced not by the judge's ruling per se but by the causal basis for that ruling. Conceptual and practical implications are discussed.
NITROUS OXIDE EMISSION DEPENDING ON THE TYPE OF ELECTRON ACCEPTOR BY A DENITRIFYING PHOSPHORUS REMOVAL SLUDGE

Denitrifying polyphosphate accumulating organisms (DNPAOs) are very promising for simultaneous nitrogen and phosphorus removal. While during denitrification, emission of a greenhouse gas, nitrous oxide (N2O), may occur. In this study, DNPAOs were enriched in a lab-scale reactor, and N2O emission was examined under different electron acceptor conditions. During the anoxic phase, with the uptake of phosphorus, denitrification of nitrate nitrogen (NO3-N) was observed without the accumulation of nitrite nitrogen (NO2-N). In general, a very low amount of N2O was produced with nitrate as the electron acceptor, independent of the applied different nitrate concentrations. However, with nitrite as the electron acceptor, a much higher N2O emission occurred. The N2O emission factor to the denitrified NO2N was 6.2%, 5.3% and 4.9% at the initial NO2-N concentration of 10, 20 and 40 mg l, respectively. In addition, a much higher N2O emission occurred with the co-existence of NO3-N and NO2-N. The initial organic carbon concentration had no significant effect on N2O emission with NO3-N as the electron acceptor. When stored organic carbon by DNPAOs was used as the electron donor, N2O emission was mainly dependent on the electron acceptor.
SOURCE: Sheridan Institutional Repository SOURCE: Sheridan Institutional Repository

Regression testing analyzes whether the maintenance of the software has adversely affected its normal functioning. Regression testing is generally performed under the strict time constraints. Due to limited time budget, it is not possible to test the software with all available test cases. Thus, the reordering of the test cases, on the basis of their effectiveness, is always needed. A test prioritization technique, which prioritizes the test cases on the basis of their Time -Fault Ratio (TFR), has been proposed in this paper. The technique tends to maximize the fault detection as the faults are exposed in the ascending order of their detection times. The proposed technique may be used at any stage of software development.
Discrepancies between direct and indirect measures of interpersonal and neurocognitive skills in autism spectrum disorder children

ABSTRACT Background: Subjects with autistic spectrum disorders (ASD) show persistent deficits in social interaction. In order to explore the scope of their deficits, it is of great interest to compare the different interpersonal skills and executive functions of ASD subjects to those of children with typical development. Assessing these skills usually involves a large variety of informants (parents, teachers, other family members) and of measures, with frequent discrepancies between direct performance measures and indirect measures (third-party report). Different explanations of this mismatch between measures have been addressed in previous studies. Objectives: We wish to analyze whether there are differences between children with ASD and children with typical development on several direct performance measures of interpersonal and neurocognitive skills and one third-party report on real-life performance of interpersonal skills; we also want to look at whether discrepancies appear between the two types of measurements in the two groups of participants. Method: A total of 68 Spanish children between the ages of 7 and 12 years participated; 34 were children with ASD, and 34 showed typical development. All participants were tested for recognition of emotions, solving interpersonal conflicts, and executive function. Results: Significant differences between the two groups were not found on most of the direct performance measures, but they did appear in the report by third parties, in favor of the group with typical development. There was also a significant association between neurocognitive and social variables in the latter group. Conclusions: There were intergroup differences and discrepancies between the direct performance and indirect measures in children with ASD, and these must be explained. For this reason, future studies could seek to explain the cause of these discrepancies with a greater number of measures for each of the skills.
Eighth Joint National Committee (JNC-8) Guidelines and the Outpatient Management of Hypertension in the African-American Population

Background: Hypertension is a common medical disease, occurring in about one third of young adults and almost two thirds of individuals over the age of 60. With the release of the Eighth Joint National Committee on Prevention, Detection, Evaluation, and Treatment (JNC-8) guidelines, there have been major changes in blood pressure management in the various subgroups. Aim: Optimal blood pressure management and markers of end-organ damage in African-American adult patients were compared between patients who were managed according to the JNC-8 hypertension management guidelines and those who were treated with other regimens. Materials and Methods: African-American patients aged 18 years or older with an established diagnosis of hypertension were included in the study who were followed up in our internal medicine clinic between January 1, 2013 and December 31, 2103; the data on their systolic and diastolic blood pressure readings, heart rate, body mass index (BMI), age, gender, comorbidities, and medications were recorded. Patients were divided into four groups based on the antihypertensive therapy as follows - Group 1: Diuretic only; Group 2: Calcium channel blocker (CCB) only; Group 3: Diuretic and CCB; Group 4: Other antihypertensive agent. Their blood pressure control, comorbidities, and associated target organ damage were analyzed. Results: In all 323 patients, blood pressures were optimally controlled. The majority of the patients (79.6%) were treated with either a diuretic, a CCB, or both. Intergroup comparison analysis showed no statistically significant difference in the mean systolic blood pressure, mean diastolic blood pressure, associated comorbidities, or frequency of target organ damage. Conclusion: Although diuretics or CCBs are recommended as first-line agents in African-American patients, we found no significant difference in the optimal control of blood pressure and frequency of end-organ damage compared to management with other agents.
Massive molecular outflows and evidence for AGN feedback from CO observations

We study the properties of massive, galactic-scale outflows of molecular gas and investigate their impact on galaxy evolution. We present new IRAMPdBI CO(1-0) observations of local ultra-luminous infrared galaxies (ULIRGs) and quasar-hosts: a clear signature of massive and energetic molecular outflows, extending on kpc scales, is found in the CO(1-0) kinematics of four out of seven sources, with measured outflow rates of several 100M(circle dot)yr(-1). We combine these new observations with data from the literature, and explore the nature and origin of massive molecular outflows within an extended sample of 19 local galaxies. We find that starburst-dominated galaxies have an outflow rate comparable to their star formation rate (SFR), or even higher by a factor of similar to 2-4, implying that starbursts can indeed be effective in removing cold gas from galaxies. Nevertheless, our results suggest that the presence of an active galactic nucleus (AGN) can boost the outflow rate by a large factor, which is found to increase with the L-AGN/L-bol ratio. The gas depletion time scales due to molecular outflows are anti-correlated with the presence and luminosity of an AGN in these galaxies, and range from a few hundred million years in starburst galaxies down to just a few million years in galaxies hosting powerful AGNs. In quasar hosts, the depletion time scales due to the outflow are much shorter than the depletion time scales due to star formation. We estimate the outflow kinetic power and find that, for galaxies hosting powerful AGNs, it corresponds to about 5% of the AGN luminosity, as expected by models of AGN feedback. Moreover, we find that momentum rates of about 20 L-AGN/c are common among the AGN-dominated sources in our sample. For "pure" starburst galaxies, our data tentatively support models in which outflows are mostly momentum-driven by the radiation pressure from young stars onto dusty clouds. Overall, our results indicate that, although starbursts are effective in powering massive molecular outflows, the presence of an AGN may strongly enhance such outflows, and therefore have a profound feedback effect on the evolution of galaxies by efficiently removing fuel for star formation, hence quenching star formation.
Evaluation of the effects of dietary particle fractions on fermentation profile and concentration of microbiota in the rumen of dairy cows fed grass silage-based diets

The study evaluated the effects of three different theoretical particle lengths (TPL) of grass silage on the distribution of particle fractions of the diet and the resulting effects on fermentation profile and concentrations of protozoa and mixed bacterial mass in the rumen of three lactating Holstein cows fed total mixed rations (45% grass silage, 5% grass hay and 50% concentrate) ad libitum. Decreasing TPL of grass silage (long, medium, short) reduced particles retained on the 19-mm sieve of the Penn State Particle Separator, while particle fractions from 8 mm to 19 mm and smaller than 8 mm were increased. Different TPL did not affect pH and the concentration of volatile fatty acids in the rumen. However, lowering the TPL from long to medium increased significantly the bicarbonate concentration, acetate proportion and protozoal number in the rumen, whereas the proportion of bacterial protein in ruminal digesta and its amino acid concentration were significantly increased by the short TPL. For the current feeding conditions, it can be concluded that increasing the fraction of particles between 8 and 19 mm and probably even the fraction below 8 mm by decreasing TPL of grass silage do not adversely affect rumen conditions and can be beneficial in terms of optimising concentration and activity of ruminal microbiota in high-yielding dairy cows.
Cold damage to the extremities: frostbite and non-freezing cold injuries

The treatment of cold injuries to the periphery has advanced substantially in the last 10 years and optimal outcomes are only likely to be achieved if a multidisciplinary team uses the full range of diagnostic and treatment modalities that are now available. The internet and satellite phones with digital images allow immediate access by patients from remote geographical locations to hospital based specialists who can assess cold injuries and advise on early field care. The severity of frostbite injuries can now be assessed with triple phase bone scanning, allowing early prediction of likely subsequent tissue loss. Early hyperbaric oxygen therapy appears to improve outcome and the use of intravenous drugs such as synthetic prostaglandin analogues infusions and tissue plasminogen activator have been shown to reduce amputation rates. In non-freezing cold injuries the early administration of analgesia, the avoidance of secondary exposure, and the use of infrared thermography to assess the injuries are among newer approaches being introduced.
Effect of fish oil supplementation in pregnancy on the fatty acid composition of erythrocyte phospholipids and breast milk lipids

To investigate the effect of n-3 polyunsaturated fatty acid (PUFA) supplementation on the fatty acid composition of erythrocyte phospholipids and breast milk lipids, pregnant Brazilian women in the 30th week of gestation were randomized to supplement their usual diet with 2 g/day of fish oil (FO group) or primrose oil (PO group, control) capsules for 15 days. Erythrocyte phospholipids from FO group had proportionally higher docosahexaenoicacid and eicosapentaenoic acid levels and furthermore, the ratio of n-6/n-3 PUFA was significantly lower in the breast milk lipids compared with the control group. Assessment of plasma anti-oxLDL autoantibodies and thiobarbituric acid-reactive substance concentration demonstrated that both groups had the same levels and they were unaltered by supplementations.
Neural Correlate of Perceptual Adaptation to Gratings

Exposure of simple cells of the cat striate cortex to high-contrast drifting gratings greatly reduces the subsequent response of the cells to low-contrast gratings. This adaptation effect has an average duration of 30 seconds and shows interocular transfer and selectivity for spatial frequency and orientation. This effect is strikingly similar to the perceptual adaptation to high-contrast gratings.
Data-driven phonetic comparison and conversion between south african, british and american English pronunciations

We analyse pronunciations in American, British and South African English pronunciation dictionaries. Three analyses are perfomed. First the accuracy is determined with which decision tree based grapheme-to-phoneme (G2P) conversion can be applied to each accent. It is found that there is little difference between the accents in this regard. Secondly, pronunciations are compared by performing pairwise alignments between the accents. Here we find that South African English pronunciation most closely matches British English. Finally, we apply decision trees to the conversion of pronunciations from one accent to another. We find that pronunciations of unknown words can be more accurately determined from a known pronunciation in a different accent than by means of G2P methods. This has important implications for the development of pronunciation dictionaries in less-resourced varieties of English, and hence also for the development of ASR systems.
Kalman filtering for wireless networks systems with delayed-missing measurements

The paper is concerned with the Kalman filtering problem for linear discrete-time network systems with delayed-missing measurements. The Kalman filter and the corresponding covariance matrix become stochastic, since the measurements are partial (or part or all of the measurements are lost). The re-organized innovation analysis approach is proposed to deal with such a problem, and the calculation of the filter involves two Riccati equations associated with two normal Kalman filter of a delay-free system. The Riccati equations have the same dimension as the system.
Protection and recovery in influenza virus-infected mice immunosuppressed with anti-IgM.

BALB/c mice, immunosuppressed from birth with goat anti-mouse IgM, were able to recover from influenza virus infection in the absence of detectable serum and nasal antibody. Recovery was delayed a few days when compared with control animals. Antibody-deficient mice, that had recovered from an initial influenza virus infection, i.e., convalescent mice, were subsequently rechallenged with homologous influenza virus in order to study the importance of nasal and serum antibody in prevention of infection. Convalescent mice were susceptible to reinfection when nasal and serum antibody were not detectable. The mice were resistant to reinfection when serum and/or nasal antibody was detectable by radioimmunoassay. Normal mice that were passively immunized with high titer mouse anti-influenza virus serum were susceptible to challenge with homologous influenza virus. The serum antibody levels in these mice were higher than most of those found in the immune convalescent mice suppressed with anti-IgM, thereby suggesting that the serum antibody, found in convalescent suppressed mice, is not protective. We conclude that 1) mice can recover from influenza virus infection in the absence of detectable levels of nasal and serum antibody, thus indirectly confirming the role of cell-mediated immunity in recovery; 2) serum IgM, IgG2A, IgG2B, IgG3, and probably IgG1 antibody levels are not responsible for protection against influenza virus infection of the upper respiratory tract; and 3) nasal IgA antibody correlates best with protection against reinfection of the upper respiratory tract, but some other locally protective agent cannot be excluded.
Are Urban Agglomerations a Better Breeding Place for Product Innovation? An Analysis of New Product Announcements

BROUWER E. , BUDIL-NADVORNIKOVA H. and KLEINKNECHT A. (1999)Are urban agglomerations a better breeding place for product innovation? An analysis of new product announcements, Reg. Studies 33 , 541-549. Regions matter for innovative behaviour. Compared to firms in rural regions, firms in urban agglomerations of the Netherlands dedicate a higher share of their R&D to product (rather than process) development. Moreover, in our Hurdle Count Data estimate of determinants of new product announcementswe find that, with a given product R&D intensity, firmsin central regions have higher probabilities of announcing at least one new product in a journal and they also announce new products in larger numbers. The results add to the literature on regional knowledge spillovers. BROUWER E. , BUDIL-NADVORNIKOVA H. et KLEINKNECHT A. (1999) Le role des agglomerations urbaines en tant que pepinieres de l'innovation de produits: une analyse des annonces concernant lelancement denouveaux produits, Reg. Studies 33 , 541-549. Les .
Neuroprotective lifestyles and the aging brain

Objectives: Increased participation in leisure and physical activities may be cognitively protective. Whether activity might protect the integrity of the brain's white matter, or reduce atrophy and white matter lesion (WML) load, was examined in the Lothian Birth Cohort 1936 (n = 691), a longitudinal study of aging. Methods: Associations are presented between self-reported leisure and physical activity at age 70 years and structural brain biomarkers at 73 years. For white matter integrity, principal components analysis of 12 major tracts produced general factors for fractional anisotropy (FA) and mean diffusivity. Atrophy, gray and normal-appearing white matter (NAWM) volumes, and WML load were assessed using computational image processing methods; atrophy and WML were also assessed visually. Results: A higher level of physical activity was associated with higher FA, larger gray and NAWM volumes, less atrophy, and lower WML load. The physical activity associations with atrophy, gray matter, and WML remained significant after adjustment for covariates, including age, social class, and health status. For example, physical activity (standardized β = −0.09, nonstandardized β = −0.09, p = 0.029) and stroke (standardized β = 0.18, nonstandardized β = 0.69, p = 0.003) each had an independent effect on rated WML load. Leisure activity was associated with NAWM volume, but was nonsignificant after including covariates. Conclusions: In this large, narrow-age sample of adults in their 70s, physical activity was associated with less atrophy and WML. Its role as a potential neuroprotective factor is supported; however, the direction of causation is unclear from this observational study.
Development of Anaerobic Fitness in Top-Level Competitive Youth Ice Hockey Players

Abstract Leiter, JR, Cordingley, DM, and MacDonald, PB. Development of anaerobic fitness in top-level competitive youth ice hockey players. J Strength Cond Res 32(9): 2612–2615, 2018—Ice hockey is a physiologically complex sport involving both the anaerobic and aerobic energy systems. The purpose of this study was to evaluate the anaerobic power output (PO) of top-level competitive youth hockey players. It was hypothesized that with each successive increase in age, there would be an associated change in anaerobic PO. Two hundred and fifty-one male hockey players between the ages of 13–17 years participated in this study. All athletes completed a 30-second Wingate test as part of a preseason physiological and fitness combine. A 1-way analysis of variance was performed to compare peak PO (POpeak), average PO (POavg), and fatigue index between all age groups. A Tukey's post hoc test was used to determine changes in immediately successive age groups for all variables. Age categories were grouped as 13 years old (yrs) (n = 72), 14 yrs (n = 68), 15 yrs (57) and 16 yrs (n = 54, including 11 athletes 17 yrs). Absolute POpeak significantly increased with all age increases. Relative POpeak, absolute POavg, and relative POavg increased between the ages of 13 and 14 years, and 14 and 15 years, but not between the ages 15 and 16 years. There were no changes in fatigue index between any successive age groups. Anaerobic PO increases with an increase in age with no associated change in fatigue index. Athletes, coaches, and parents can use this normative data to help prepare the player for upcoming seasons in which there may be an increase in level or age class.
Applications of Multi-criteria Decision Making in Software Engineering

Every complex problem now days require multicriteria decision making to get to the desired solution. Numerous Multi-criteria decision making (MCDM) approaches have evolved over recent time to accommodate various application areas and have been recently explored as alternative to solve complex software engineering problems. Most widely used approach is Analytic Hierarchy Process that combines mathematics and expert judgment. Analytic Hierarchy Process suffers from the problem of imprecision and subjectivity. This paper proposes to use Fuzzy AHP (FAHP) instead of traditional AHP method. The usage of FAHP helps decision makers to make better choices both in relation to tangible criteria and intangible criteria. The paper provides a clear guide on how FAHP can be applied, particularly in the software engineering area in specific situations. The conclusion of this study would help and motivate practitioners and researchers to use multi-criteria decision making approaches in the area of software engineering.