Miracle-dz/UniFAR-FTUs huggingface dataset:
Identification of four proteins from the small subunit of the mammalian mitochondrial ribosome using a proteomics approach

Proteins in the small subunit of the mammalian mitochondrial ribosome were separated by two‐dimensional polyacrylamide gel electrophoresis. Four individual proteins were subjected to in‐gel Endoprotease Lys‐C digestion. The sequences of selected proteolytic peptides were obtained by electrospray tandem mass spectrometry. Peptide sequences obtained from in‐gel digestion of individual spots were used to screen human, mouse, and rat expressed sequence tag databases, and complete consensus cDNAs for these species were deduced in silico. The corresponding protein sequences were characterized by comparison to known ribosomal proteins in protein databases. Four different classes of mammalian mitochondrial small subunit ribosomal proteins were identified. Only two of these proteins have significant sequence similarities to ribosomal proteins from prokaryotes. These proteins are homologs to Escherichia coli S9 and S5 proteins. The presence of these newly identified mitochondrial ribosomal proteins are also investigated in the Drosophila melanogaster, Caenorhabditis elegans, and in the genomes of several fungi.
miR-185 Suppresses Tumor Proliferation by Directly Targeting E2F6 and DNMT1 and Indirectly Upregulating BRCA1 in Triple-Negative Breast Cancer

Breast cancer is a major public health problem all over the world, and the current treatment strategies are not potent enough for some patients, especially those with triple-negative breast cancer (TNBC). Recent studies have demonstrated that microRNAs (miRNA) play vital roles in the development of TNBC. In this study, we found that miR-185 was strongly downregulated in TNBC tissues and cell lines and that its expression levels were associated with lymph node metastasis, clinical stage, overall survival, and relapse-free survival in TNBC. We also found that ectopic expression of miR-185 inhibited TNBC cell proliferation in vitro and in vivo. We further identified that miR-185 directly targeted DNMT1 and E2F6, which resulted in a marked increase in the expression of BRCA1 at the mRNA and protein levels in TNBC. Our data suggest that miR-185 functions as a tumor suppressor in TNBC development. It is a promising prognostic biomarker and potential therapeutic target for TNBC. Mol Cancer Ther; 13(12); 3185–97. ©2014 AACR.
Linking Work Design and Corporate Social Responsibility Through an Exploratory Model for the Interdependency of Work Characteristics and Corporate Social Responsibility Orientation

Linking Work Design and Corporate Social Responsibility Through an Exploratory Model for the Interdependency of Work Characteristics and Corporate Social Responsibility Orientation. (December 2011) Priya Darshini Kurup, B.A., Bharathiar University; M.A., University of Calicut Co-Chairs of Advisory Committee: Dr. Mary Alfred Dr. Homer Tolson Driven by the demands of drastic changes in today’s nature of work due to globalization and technological advances, researchers have continually revisited, redesigned, and restructured work design processes in a quest to identify the key characteristics that can result in desired organizational outcomes. Specifically, in current times, organizations are looking to develop socially responsible outcomes, otherwise referred as corporate social responsibility (CSR). A possible link between work design and CSR has been postulated by researchers, but few studies have emerged where the associations between work design and CSR factors are examined. The purpose of this study was to explore the link between work design and CSR using a work design-CSR conceptual model that was developed based on previous literature. The model depicted relationships between work design factors and CSR factors. Work design factors included work characteristics and worker characteristics. Work characteristics were measured using task, knowledge, social, and contextual
FACTORIZATION OF n-SOLUBLE AND n-NILPOTENT GROUPS

then we term the elements x and y n-commutative. It is not difficult to verify that n-commutativity and (1 -n)-commutativity are equivalent properties of the elements x and y, that (I)-commutativity implies ordinary commutativity, and that commuting elements are n-commutative. From any concept and property involving the fact that certain elements [or functions of elements] commute, one may derive new concepts and properties by substituting everywhere n-commutativity for the requirement of plain commutativity. This gen,eral principle may be illustrated by the following examples. n-abelian groups are groups G such that (xy)n =xnyn for every x and y in G. They have first been discussed by F. Levi [31; and they will play an important r6le in our discussion. Grun [2] has introduced the n-commutator subgroup. It is the smallest normal subgroup J of G such that G/J is n-abelian; and J may be generated by the totality of elements of the form (xy)n(xnyn)with x and y in G. Dual to the n-commutator subgroup is the n-center. It is the totality of elements z in G such that (zx) = znxn and (xz)"n = xzn for every x in G; see Baer [1] for a discussion of this concept.
Can Empowerment and Organizational Support for Development Stem Turnover? It Depends on Power Distance

Research on the effects of psychological empowerment and organizational support for development (OSD) on turnover reveals mixed findings. Based on attraction–selection–attrition theory, we developed a model that examines individual-level power distance as a moderator of the relationships between psychological empowerment and turnover and OSD and turnover. Using a sample of 240 employees of a US software development company in India, we found that psychological empowerment was associated with higher turnover for high power distance employees and lower turnover for low power distance employees. Additionally, OSD was associated with higher turnover for high power distance individuals.
The local impact of global climate change: reporting on landscape transformation and threatened identity in the English regional newspaper press

This paper contributes to extant understandings of media representations of climate change by examining the role of the English regional newspaper press in the transformation and dissemination of climate change discourse. Unlike previous accounts, this paper contends that such newspapers shape public understandings of climate change in ways that have yet to be adequately charted. With this in mind, this paper examines the ways in which global climate change is translated into a locally relevant phenomenon. That is, it focuses on its “domestication. ” Although we acknowledge that there are a number of ways in which this process occurs, specific attention is drawn to stories that highlight the destruction of local landscape features, the transformation of important habitats, and the arrival of “alien” species. The broader significance of such stories is considered in relation to long-standing debates concerning the importance of landscape to notions of national and regional identity.
Who Benefits from Voluntary Disclosure? Evidence from Italian Market Microstructure Data

Using proprietary market microstructure data of Milan Stock Exchange and strategic plan presentations of Italian firms as disclosure events we explore the distributional effects of voluntary disclosure. We document systematic trading patterns around our disclosure events that on average generate two-month positive abnormal returns of 5.9% for investors trading large shares, while investors trading small shares experience negative abnormal returns of 5.3%. This economically large wealth distribution effect is triggered by large investors increasing their stakes in disclosing firms prior to news arrival irrespective of the nature of the news. Around news arrival, they sell their inventory to small investors in case of bad news. Our findings are particularly pronounced for smaller firms with event-related media coverage, and are consistent with sophisticated investors systematically exploiting attention-based trading behavior of unsophisticated investors triggered by the public dissemination of voluntary disclosure information in the Italian market.
Maintaining cold chain integrity: Temperature breaks within fruit reefer containers in the Cape Town Container Terminal

South Africa is among the top 10 fruit-exporting countries in the world. The South African fruit industry has identifi ed temperature breaks along the fruit export cold chain that result in the deterioration of fruit quality, loss of market credibility, and fi nancial losses. Seventy percent (70%) of South African fruit exports are shipped through the Cape Town Container Terminal (CTCT). This in-depth case study provides a better understanding of the signifi cant challenges within the CTCT. This research revealed that 81% of the temperature breaks in fruit reefer containers carrying summer fruit originate within the CTCT. The average time for a reefer container to be plugged in from when it enters the port is 1 hour and 52 minutes; almost three times higher than the 40-minute goal time. Only one-fi fth of containers experienced no temperature breaks, while almost a quarter never cooled down to the target temperature. Operational issues that need to be addressed have been identifi ed, such as the increased use of gensets, improved scheduling for arrival at the CTCT, and training of port personnel as to the correct standards for cold chain management. There is, however, also a need for improved collaboration between the producers, fruit exporters, logistics service providers, the CTCT, and shipping lines to enable end-to-end integrity of the cold chain. The latter will be the subject of future research. Key words: fruit exports; reefer containers; cold chain; Cape Town Container Terminal; temperature breaks
Sentinel node mapping for gastric cancer: a prospective multicenter trial in Japan.

PURPOSE Complicated gastric lymphatic drainage potentially undermines the utility of sentinel node (SN) biopsy in patients with gastric cancer. Encouraged by several favorable single-institution reports, we conducted a multicenter, single-arm, phase II study of SN mapping that used a standardized dual tracer endoscopic injection technique. PATIENTS AND METHODS Patients with previously untreated cT1 or cT2 gastric adenocarcinomas < 4 cm in gross diameter were eligible for inclusion in this study. SN mapping was performed by using a standardized dual tracer endoscopic injection technique. Following biopsy of the identified SNs, mandatory comprehensive D2 or modified D2 gastrectomy was performed according to current Japanese Gastric Cancer Association guidelines. RESULTS Among 433 patients who gave preoperative consent, 397 were deemed eligible on the basis of surgical findings. SN biopsy was performed in all patients, and the SN detection rate was 97.5% (387 of 397). Of 57 patients with lymph node metastasis by conventional hematoxylin and eosin staining, 93% (53 of 57) had positive SNs, and the accuracy of nodal evaluation for metastasis was 99% (383 of 387). Only four false-negative SN biopsies were observed, and pathologic analysis revealed that three of those biopsies were pT2 or tumors > 4 cm. We observed no serious adverse effects related to endoscopic tracer injection or the SN mapping procedure. CONCLUSION The endoscopic dual tracer method for SN biopsy was confirmed as safe and effective when applied to the superficial, relatively small gastric adenocarcinomas included in this study.
Fulfilling the promises: the impacts of employment relationship on turnover intention

Abstract Public sector organizations have faced crucial human resource management threats with increasing turnover rates and vast retirements, which would make turnover research more important ever. To investigate turnover intention of public employees in South Korea, this study employed psychological contract theory and examined the impacts of psychological contract fulfillment on turnover intention. With 2016 Public Employee Perception Survey data, this study found that transactional and relational contract, and perceived organizational support were negatively associated with turnover intention of public employees in South Korea. As a result, this study maintains that public organizations in South Korea should keep their promises on compensation, non-monetary incentives, and employee well-being programs to their employees not only to hold valuable current employees, but also to attract new and young talents.
Why and how to report surgeons’ levels of expertise

An eminent arthroscopic surgeon was asked by us, ‘If a beginner reported poor results using your technique, would you know whether it is your technique that led to the poor results or the surgeon’s poor execution of the technique? ’ He replied, ‘I cannot know unless he had reported that he is a beginner’. This illustrates why the level of expertise of surgeons performing procedures should be reported. This is even clearer for a comparative study, because comparison of outcomes between surgeons of significantly different levels of expertise is invalid. Surprisingly, this important information is usually missing in published articles. Recently, the need to include such information has drawn a great deal of attention from the editorial board of the Journal. We established a panel consisting of senior surgeons with extensive publication and review experience to address information and its integration into future published articles. After hearing from the panel, the Editors agreed the following.
Teaching medicine with cases: student and teacher opinion

Summary. In a second‐year family medicine course taught using simulated patients the students commented most favourably on the clinical relevance of the topics, the enthusiasm of teachers, and the opportunity to interview simulated patients with their fellow students, in contrast to their basic science courses, which did not give them patient contact. They felt most confident about skills acquired in relation to diseases with a limited number of key symptoms, signs and treatments (meningitis, otitis) and less confident about diseases with many symptoms and treatments (diabetes, trauma, arrhythmias). They made few comments about alternative cases which might have been selected. Their adverse comments were about the workload.
The Influence of Critical Success Factors on B2B Sales Performance and the Mediating Role of Social Intelligence

In this study; the characteristics of sales representatives related to their sales performance such as learning orientation, customer orientation, intrinsic motivation, hardworking and technical expertise were defined as “Critical Success Factors in Selling” and the mediating role of social intelligence between these and sales performance were investigated. Data collected from 376 sales representatives from 125 different companies showed that social intelligence has strong influence over sales performance and plays a mediating role between critical success factors in selling and sales performance.
The Use of a Home Exercise Program Based on a Computer System in Patients With Chronic Obstructive Pulmonary Disease

PURPOSE: To test the effectiveness of a home exercise program based on a user-friendly, computer system, the Nintendo Wii Fit. METHODS: In this longitudinal study, 25 clinically stable patients with chronic obstructive pulmonary disease began a 6-week nonintervention (baseline) period followed by 12 weeks of Wii exercise training at home. Patients were instructed to exercise 5 or more days per week. Exercise capacity, health status, and dyspnea were evaluated after home exercise training. RESULTS: Evaluable data were available in 20 patients after home exercise training; their force expiratory volume in 1 second was 45 ± 16%. Following 12 weeks of Wii exercise training, the Endurance Shuttle Walk Test increased by 131 ± 183 seconds over the baseline determination (P = .005). Significant improvements were also noted in arm-lift and sit-to-stand repetitions, the total score, and the emotion dimension of the Chronic Respiratory Questionnaire. Men had significantly greater increases in the Endurance Shuttle Walk Test than women, although their self-reported exercise durations were similar. There were no significant adverse outcomes. CONCLUSION: This study suggests that 12 weeks of regular, home exercise based on an interactive entertainment computer system can lead to positive short-term outcomes.
Speaking to the dead: Images of the dead in contemporary art

In this article I explore works by three artists in which we can see images that relate to bereavement. In the work of the first two, Araya Rasdjarmrearnsook and Andres Serrano, we can see photographic images (still and moving) of human corpses, which have been criticized as morbid and unhealthy. However I argue that it is not in fact images of death or the dead that are problematic but those images which present or evoke evidence of the emotions associated with death, and create a situation where we imagine the circumstances of our own deaths or the death of those we love. Images of the dead are acceptable as long as they do not cause pain to the living, as in a video game fantasy or a fiction, or are seen as other and distant. In the second group of works, by Gustgav Metzger, The Absent Dead: The Surrogate Body, the body is not present either because the death has taken place at a distance, either in time or geographically, or both, and a new site must be created. In this section, I discuss Metzger’s auto-destructive art and argue that these works, through their ephemerality, embody a form of ‘meaning making’ and a possibility of the benefits of grief as described by Parkes.
Discrete Autoencoders for Sequence Models

Recurrent models for sequences have been recently successful at many tasks, especially for language modeling and machine translation. Nevertheless, it remains challenging to extract good representations from these models. For instance, even though language has a clear hierarchical structure going from characters through words to sentences, it is not apparent in current language models. We propose to improve the representation in sequence models by augmenting current approaches with an autoencoder that is forced to compress the sequence through an intermediate discrete latent space. In order to propagate gradients though this discrete representation we introduce an improved semantic hashing technique. We show that this technique performs well on a newly proposed quantitative efficiency measure. We also analyze latent codes produced by the model showing how they correspond to words and phrases. Finally, we present an application of the autoencoder-augmented model to generating diverse translations.
Influence of the Alpha-Adducin and ACE Gene Polymorphism on the Progression of Autosomal-Dominant Polycystic Kidney Disease

Background: A significant phenotypical variability is observed in autosomal dominant polycystic kidney disease (ADPKD). The variability can not be fully explained by the genetic heterogenity of the disease. We examined the influence of the ACE I/D polymorphism, adducin Trp460Gly polymorphism and the association of both polymorphisms on the progression of ADPKD towards end-stage renal failure (ESRF). Methods: 320 ADPKD patients (pts) were analyzed, 220 pts (113 males, 107 females) with ESRF before 63 years of age, with a subgroup (rapid progressors) of 20 pts (12 males, 8 females) with ESRF before 40 years of age, 52 pts (23 males, 29 females) with ESRF later than 63 years of age (slow progressors), 48 ADPKD pts (18 males, 30 females) with mean age ±50 years with serum creatinine <110 µmol/l (slow progressors) and 200 genetically unrelated healthy Czech subjects. DNA samples from collected blood were genotyped for the ACE I/D polymorphism and the Trp460Gly of α-adducin gene polymorphism. Results: The α-adducin genotypes showed no differences among the groups of slow progressors (74% Gly/Gly, 22.9% Gly/Trp and 3.1% Trp/Trp), pts with ESRF before 63 years of age (67.7% Gly/Gly, 30.5% Gly/Trp and 1.8% Trp/Trp) and rapid progressors (75% Gly/Gly, 25% Gly/Trp). The ACE genotypes did not differ among the groups of slow progressors (27.1% I/I, 44.8% I/D and 28.1% D/D), pts with ESRF before 63 years of age (23.6% I/I, 51.4% I/D and 25% D/D) and rapid progressors (20% I/I, 55% I/D and 25% D/D). The distribution did not differ from the control group. The ages of ESRF according to different genotypes did not significantly differ. We observed a significant tendency to better prognosis in Trp allele carriers for I/I genotype in comparison with Gly/Gly homozygous subjects. Conclusion: The ACE and α-adducin polymorphisms do not play a significant role in the progression of ADPKD to ESRF.
The Left Thoracic Curve Pattern: A Strong Predictor for Neural Axis Abnormalities in Patients With “Idiopathic” Scoliosis

Study Design. A prospective trial of MRI study in patients with “idiopathic” left thoracic scoliosis. Objective. To investigate the prevalence of neural axis abnormalities in asymptomatic patients with “idiopathic” left thoracic scoliosis. Summary of Background Data. Some patients with neural axis abnormalities have scoliosis as the only presenting sign, and they might be given a diagnosis of “idiopathic” scoliosis. These neural axis abnormalities are risk factors for neurologic injury during spine correction. With the development of MRI, neural axis abnormalities are increasingly being found in patients with “idiopathic” scoliosis. However, there are few reports on the prevalence of neural axis abnormalities in asymptomatic patients with “idiopathic” left thoracic scoliosis. Methods. A total of 68 patients with presumed “idiopathic” left thoracic scoliosis were examined for neural axis abnormalities, using MRI. Results. Neural axis abnormalities were detected in 37 (54%) patients, including Chiari 1 malformation in 15 patients, Chiari 1 malformation with syringomyelia in 10, Chiari 1 malformation with syringomyelia and tethered cord in 1, Chiari 1 malformation with syringomyelia and diastematomyelia in 1, syringomyelia in 8, syringomyelia with tethered cord in 1, and arachnoidal cyst in cerebellomedullary cistern in 1 patient. There were statistically significant differences between patients with and without neural axis abnormalities regarding gender and curve severity (P < 0.05). Conclusion. When a left thoracic curve pattern is present in patients with “idiopathic” scoliosis, especially in male patients or patients with severe curve, strong consideration should be given to the possibility of the presence of neural axis abnormalities, and acquisition of an MRI scan considered.