Miracle-dz/UniFAR-FTUs huggingface dataset:
Gerontological Society of America symposium " Quantitative Approaches to Aging and Exceptional Longevity " San Francisco

Centenarians (persons living to age 100 and over) represent a population, which could be useful in identifying factors leading to long life and avoidance of fatal diseases. This study explores whether people living to 100 and beyond were any different from their peers at their middle age (30 years) in terms of their physical characteristics (height and body build), occupation and marital status. A random representative sample of 240 men born in 1887 and survived to age 100 was selected from the US Social Security Administration database. These records of men with exceptional longevity were then linked to the US WWI draft registration cards collected in 1917 when these men were 30 years old. This allowed us to validate 171 cases of exceptional longevity, and obtain information on vital characteristics of male centenarians when they were young adults. Randomly selected shorter-lived men matched with centenarian men by birth year, race and county of draft registration were used as controls. This approach allowed us to eliminate confounding effects of birth cohort, race and place of draft registration on survival. It was found that the ‘stout’ body build (being in the heaviest 15% of population) was negatively associated with survival to age 100 years. Both farming and having large number of children (4+) at age 30 significantly increased the chances of exceptional longevity by 100-200%. The effects of immigration status, marital status, and body height on longevity were less important,
A complex nonlinear exponential autoregressive model approach to shape recognition using neural networks

A complex nonlinear exponential autoregressive (CNEAR) process which models the boundary coordinate sequence for invariant feature extraction to recognize arbitrary shapes on a plane is presented. A neural network structure is constructed to calculate all the CNEAR coefficients synchronically. The network is simple in structure and easy to implement. The nonlinear parameter is easy to determine using the network. The coefficients are adopted to constitute the feature set. They are proven to be invariant to the transformation of a boundary such as translation, rotation, scale, and choice of the starting point in tracing the boundary. Afterwards, the feature set is used as the input to a complex multilayer perceptron (C-MLP) network for learning and classification. Experimental results show that complicated shapes can be recognized with high accuracy, even in the low-order models. It is also seen that the CNEAR model performs better than the complex autoregressive (CAR) model when shapes have random noise on the boundaries or have differentiating features at detailed levels. Finally, an extended training scheme is developed in which the network is gradually retrained sequentially with shapes containing small increments of noise to improve the robustness of the C-MLP classifier.
Dense Stereo Matching for Urban Outdoor Scenes

Dense stereo matching is an active research topic in the area of Computer Vision. Depth information is extracted from a dense correspondence search between two or more images of the same scene, taken from different camera positions. Extracted depth information can be used for various applications such as robotic navigation, automated driving or 3D reconstruction of objects and buildings. In this work we will focus on dense stereo matching for urban outdoor environments. We start from the recently published PatchMatch Stereo approach by Bleyer et al. [8] since it seems suitable for our purpose in terms of memory consumption and scalability for high resolution images. We further extend their idea to multi-view stereo. Our algorithm is tested on different urban outdoor image sets, including image pairs from cameras mounted on a car, panoramic images of urban areas as well as multi-view data from historic sites and aerial image data. For the correspondence search, experiments with different cost functions are performed. PatchMatch Stereo is a local stereo matching approach that estimates a 3D plane at each pixel position, hence, extracting not only disparity values but also surface normals. The PatchMatch Stereo algorithm is based on a randomized approximate correspondence search. Initially a random plane is selected for each pixel position. Good plane estimates are then propagated to neighboring pixels and further refined in an iterative process. We transform the PatchMatch Stereo approach to scene space in order to directly estimate depth values and work with non-rectified images. Mapping from one image to another is facilitated by plane induced homographies, utilizing the estimated planes (normal and depth) at each pixel position. Processing in scene space allows us to directly combine multiple images. The major contribution of our work is a multi-view stereo matching approach. The use of more than two images facilitates the handling of partially occluded image regions and therefore leads to more robust results. Our approach is quantitatively evaluated on existing benchmark data for two-view and multi-view image sequences. Results are compared with reported values of state-of-the-art stereo matching methods.
Contextual perceived value?: Investigating the role of contextual marketing for customer relationship management in a mobile commerce context

Purpose – The purpose of this paper is to propose and validate the mobile commerce (MC) consumers' repurchase intention (RPI) model including technology acceptance model (TAM), customer satisfaction (CS), and contextual perceived value (CPV) of marketing offer as a new MC‐specific construct.Design/methodology/approach – A survey instrument was used to gather data to test the relationships shown in the research model. χ2 difference test was conducted in order to examine the contribution of CPV of marketing offer in explaining MC consumers' RPI. The hypothesized relationships were tested using the structural equation modeling.Findings – The results of this study reveal that integrating CPV with CS and TAM in a single model can better explain and predict MC consumers' RPI. CPV has a significant effect on RPI, CS and perceived usefulness.Research limitations/implications – CPV activated by contextual marketing is the key factor for customer relationship management in MC context.Originality/value – The primary.
IgG4-related Sclerosing Disease: A Potential New Etiology of Cutaneous Pseudolymphoma

IgG4-related sclerosing disease is a syndrome characterized by the involvement of a wide variety of tissues by lymphoplasmacytic infiltrates and sclerosis, elevated serum IgG4 titer, and increased IgG4+ plasma cells in tissues. This report describes 2 cases with skin involvement, a feature not well documented in the literature. The patients had plaques or nodules in the skin of the cheek, temporal or periauricular region. Histologically, there was dermal and subcutaneous involvement by a nodular lymphoid infiltration often interspersed with lymphoid follicles and sclerotic stroma. The infiltrate was rich in plasma cells, small lymphocytes, and sometimes plasmablasts. The IgG4+ cell count was high (342 to 425 per high power field), with an IgG4/IgG proportion from 68% to 100%. As the morphology was compatible with pseudolymphoma, 14 cases of cutaneous pseudolymphoma were retrieved from the archives for IgG4 and IgG immunostaining. Two cases exhibited marked increase in IgG4+ cells, and showed many similarities with cutaneous manifestation of IgG4-related sclerosing disease, but the limited available clinical information precluded a conclusion on their nosologic nature. In summary, IgG4-related sclerosing disease can manifest with skin lesions, and is also one of the potential etiologies of cutaneous pseudolymphomas.
Moho map of South America from receiver functions and surface waves

[1] We estimate crustal structure and thickness of South America north of roughly 40°S. To this end, we analyzed receiver functions from 20 relatively new temporary broadband seismic stations deployed across eastern Brazil. In the analysis we include teleseismic and some regional events, particularly for stations that recorded few suitable earthquakes. We first estimate crustal thickness and average Poisson's ratio using two different stacking methods. We then combine the new crustal constraints with results from previous receiver function studies. To interpolate the crustal thickness between the station locations, we jointly invert these Moho point constraints, Rayleigh wave group velocities, and regional S and Rayleigh waveforms for a continuous map of Moho depth. The new tomographic Moho map suggests that Moho depth and Moho relief vary slightly with age within the Precambrian crust. Whether or not a positive correlation between crustal thickness and geologic age is derived from the pre-interpolation point constraints depends strongly on the selected subset of receiver functions. This implies that using only pre-interpolation point constraints (receiver functions) inadequately samples the spatial variation in geologic age. The new Moho map also reveals an anomalously deep Moho beneath the oldest core of the Amazonian Craton.
Parametric [11C]flumazenil images

ObjectiveThis [11C]flumazenil (FMZ) study evaluates the performance of various parametric analysis methods and their ability to detect statistically significant group differences. MethodsDynamic 60-min FMZ scans were performed in eight healthy and nine individuals with major depressive disorder. Parametric volume of distribution (VT) images were generated using a basis function method (BFM) implementation of the single tissue compartment model (1T) and Logan plot analysis, both with a metabolite-corrected arterial plasma input function. Parametric binding potential (BPND) images were generated using multilinear reference tissue methods (MRTM0-4), reference Logan and receptor parametric mapping (RPM1-2), with pons as a reference region. Standardized uptake value (SUV) and SUV ratio-to-pons (SUVr) images were calculated over the time interval 30–40 and 20–60 min postinjection. The resulting VT, BPND, SUV and SUVr values were compared with nonlinear regression values, using both the 1T model and the simplified reference tissue model. Statistical parametric mapping (SPM5) was used to detect group differences, with an emphasis on the bilateral parahippocampal gyri. ResultsBFM was more accurate than Logan, but showed more variability. Both RPM methods and MRTM2 showed the best average correlation with the simplified reference tissue model. In using SPM, SUV and SUVr images provided the best contrast between groups in the parahippocampal gyri, but provided large underestimation and overestimation in quantitative comparisons. BFM and RPM methods allowed for the determination of perfusion effects. ConclusionParametric Logan VT, MRTM2 and RPM1-2 BPND methods allow the best quantitative comparison of FMZ binding between groups and show good discriminating performance in SPM analysis.
The role of collegial alliance in family-based treatment of adolescent anorexia nervosa: a pilot study.

OBJECTIVE In keeping with broader efforts to identify mediators and moderators of treatment outcome in anorexia nervosa, this pilot study investigated the association between collegial alliance, which refers to the perceived alliance between case-involved professionals, and treatment outcomes in adolescent patients undergoing family-based treatment (FBT) for anorexia nervosa. METHOD The self-reported collegial alliance scores of five FBT practitioners were collected, alongside weight- and cognitive-related outcomes for 29 consecutive cases of adolescent anorexia nervosa under their care. RESULTS Collegial alliance discriminated between patients who dropped out of treatment and patients who completed treatment, t(27) = 3.68, p = . 001, η(2) = . 33. Furthermore, there was a strong negative correlation between collegial alliance scores early on in treatment and disordered eating symptoms later in treatment, r(23) = -. 67, p < . 001. Moderate but non-significant associations were observed between early collegial alliance and patient's percentage of expected body weight later in treatment, r(23) = . 32, p = . 13. DISCUSSION These findings have important implications for the augmentation of FBT, suggesting that unity amongst clinicians promotes positive treatment outcomes, particularly with regard to disordered eating symptomatology.
From Areas of American Culture Characterization Tentatively Outlined as an Aid-In the Study of the Antiquities

AS an initial step in the description and interpretation of the antiquities of the continent, the archeologist observes the tribes of today, their cultural characteristics and environments, and acquaints himself with what is known of them historically. He finds that their achievements are greatly diversified and that certain forms and states of culture characterize particular geographical areas and realizes that environment has had a large share in determining the course of the culture evolution. He examines the antiquities and finds that analogous geographical distinctions characterize the material culture of the past and reaches the conclusion that the relations of environment to man and culture must play an important part in the prosecution of his researches and in the analysis of aboriginal history.
Hepatotoxic interactions of ethanol with allyl alcohol or carbon tetrachloride in rats.

To assess whether potential toxic interactions occur between ethanol and allyl alcohol or carbon tetrachloride following subacute, concurrent chemical exposure, male Fischer 344 rats, approximately 70 d of age, were given ethanol at 0, 0.05, 0.1, 0.2, or 0.5 ml/kg in corn oil daily by gavage for 14 d (ETOH group), or the same levels of ethanol with 21 mg allyl alcohol/kg (ALAC group), or the same levels of ethanol with 20 mg carbon tetrachloride/kg (CCL4 group). Hepatic response was assessed 24 h after the last dose. Interactions were evaluated by comparing the ETOH group with either the ALAC group or the CCL4 group using multivariate analysis of variance procedures. No statistically significant interaction was seen between the ETOH group and the ALAC group at the dosages used. Although an interaction between ethanol and carbon tetrachloride given simultaneously was not statistically significant, a small interactive effect on weight gain from d 0 to termination was apparent (p = .057). Exposure to ethanol alone resulted in a concentration-dependent decrease in absolute and relative liver weight, with a threshold between 0.05 and 0.1 ml/kg. There was no histopathological evidence of hepatic damage with ethanol alone, and no effect on hepatic cytochrome P-450 and glutathione levels or on serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALK). Exposure to allyl alcohol alone resulted in significant increases in absolute and relative liver weights, liver glutathione, and periportal hepatocellular vacuolar degeneration. Exposure to carbon tetrachloride alone resulted in significant increases in absolute and relative liver weight, serum levels of ALT, AST, and ALK, and centrilobular hepatocellular vacuolar degeneration and necrosis. These observations indicate that subacute, concurrent exposure of ethanol with carbon tetrachloride or allyl alcohol at ethanol levels comparable to those reported in gavage vehicles did not result in interactive toxicity.
Properties of cell penetrating peptides (CPPs)

Different approaches have been developed for the introduction of macromolecules, proteins and DNA into target cells. Viral (retroviruses, lentiviruses, etc.) and nonviral (liposomes, bioballistics etc.) vectors as well as lipid particles have been tested as DNA delivery systems. However, all of them share several undesirable effects that are difficult to overcome, such as unwanted immunoresponse and limited cell targeting. The discovery of the cell penetrating peptides (CPPs) showing properties of macromolecules carriers and enhancers of viral vectors, opened new opportunities for the delivery of biologically active cargos, including therapeutically relevant genes into various cells and tissues. This review summarizes recent data about the best characterized CPPs as well as those sharing cell‐penetrating and cargo delivery properties despite differing in the primary sequence. The putative mechanisms of CPPs penetration into cells and interaction with intracellular structures such as chromosomes, cytoskeleton and centrioles are addressed. We further discuss recent developments in overcoming the lack of cells specificity, one of the main obstacles for CPPs application in gene therapy. In particular, we review a newly discovered affinity of CPPs to actively proliferating cells. IUBMB Life, 58: 7 ‐ 13, 2006
Bone resorption analysis of platelet-derived growth factor type BB application on collagen for bone grafts secured by titanium mesh over a pig jaw defect model

Purpose: The aim of this investigation was to evaluate whether the addition of the platelet derived growth factor type BB (PDGF-BB) to a collagen matrix applied on a titanium mesh would favor healing and resorption onto the grafted bone. A histologic and radiographic study of two different groups (test and control) was performed. Designs: A surgical procedure was performed on 8 pigs to obtain 16 bilateral mandibular alveolar defects. All the defects were then reconstructed with a mixture of autogenous bovine bone using titanium mesh positioning. Two groups, with a total of 16 defects were created: The first to study collagen sponge and PDGF-BB and the second to control collagen only. The collagen matrix was positioned directly over the mesh and soft tissue was closed without tensions onto both groups without attempting to obtain primary closure. Possible exposure of the titanium mesh as well as the height and volume of the new bone was recorded. Results: New bone formation averaged about 6.68 mm in the test group studied; the control group had less regenerated bone at 4.62 mm. Conclusion: PDGF-BB addition to the collagen matrix induced a strong increase in hard and soft tissue healing and favored bone formation, reducing bone resorption even if the mesh was exposed.
Cytopathic and Noncytopathic Interferon Responses in Cells Expressing Hepatitis C Virus Subgenomic Replicons

ABSTRACT Hepatitis C virus (HCV) is the only known positive-stranded RNA virus that causes persistent lifelong infections in humans. Accumulation of HCV RNA can be inhibited with alpha interferon (IFN-α) in vivo and in culture cells. We used cell-based assay systems to investigate the mechanisms responsible for the cytokine-induced inhibition of HCV replication. The results showed that IFN-α could suppress the accumulation of viral RNA by a noncytopathic pathway and could also induce apoptosis of virally infected cells in a concentration- and cell line-dependent fashion. Whereas the noncytopathic IFN-α response depended on a functional Jak-STAT signal transduction pathway, it did not appear to require double-stranded RNA-dependent pathways. Moreover, we found that functional proteasomes were required for establishment of the IFN-α response against HCV. Based on the results described in this study we propose a model for the mechanism by which IFN-α therapy suppresses HCV replication in chronic infections by both cytopathic and noncytopathic means.
Well-Being At Work Scale : Exploratory and Confirmatory Validation in the United States Comprising Affective and Cognitive Components

Given the lack of instruments comprising both affective and cognitive elements of WellBeing at Work (WBW), the objective of this study is to develop and validate a comprehensive scale to measure employees’ perceptions regarding their well-being. Two studies were conducted for the development and validation of the scale. Construct validity was provided through convergent, discriminant and nomological validity, assessed through the correlation between well-being at work and human resources management practices in a structural equation model. The results showed a three-factor measure with reliability, construct validity and theoretical consistency so managers can work in order to improve employee’s well-being.
Yield and Competition Indices of Intercropping Cotton (Gossypium hirsutum L.) Using Different Planting Patterns

The study reports comparative bioeconomic efficiency of different cotton based intercropping systems using high yielding cotton cv. NIAB 78 of Pakistan in 80 cm spaced rows and 120/40 cm spaced rows with cowpea and sorghum as intercrops. Land equivalent ratio showed 32-46 % advantage over sole cropping in both planting patterns. Values of Area time equivalent ratio showed 5-13 % advantage in cotton+cowpea and 9-23 % disadvantage in cotton+sorghum intercropping. Agressivity and competitive ratio showed dominancy of cotton over intercrops while intercrops were more dominant than cotton in actual yield loss values. Values of AYL showed an advantage of 32.1 % to 116.3 % from intercropping due to recovery made by intercrops. Intercropping advantage values showed intercropping disadvantage (-3.865 to -151.035) from intercropping due to price diffference of the component crop which meant that intercrops failed to compensate. Monetary advantage index values were also positive showing a definite yield advantage. Intercropping with cowpea reduced the yield of cotton, however, it seemed more appropriate for intercropping with cotton in both 80 cm and 120/40 cm spaced rows. 120/40 cm spaced rows spacing seemed better compared to single row spacing for easy handling of intercrops and sole cotton, therefore, it is recommended for mechanical farming in Pakistan.
Assessment of Differences in the Anthropometric, Physiological and Training Characteristics of Finishers and Non-finishers in a Tropical 161-km Ultra-marathon

This study aimed to compare and determine the differences in the physiological, anthropometric and training characteristics of the finishers (FIN) and non-finishers (N-FIN) in a 161-km race. Two groups of runners (FIN; N=12 and N-FIN; N=14) completed a series of anthropometric and physiological measurements over two separate sessions at least three weeks prior to the race. Training sessions starting from six weeks prior to the race were recorded. Sum of 7 skinfolds, arm and calf girths, VO2max and peak treadmill speed (PTS) were taken during session 1 while the lactate threshold (LT) and running economy (RE) were assessed during session 2. Effect size calculations showed moderate and clear differences in the lactate concentration at LT1 (ES = 0.88, P = 0.05), velocity at LT2 (ES = 0.70, P = 0.07), longest run attempted (ES = 0.73, P = 0.07) and number of cross-training hours (ES = 0.73, P = 0.06) between the FIN and N-FIN. The results suggest that from a physiological perspective, the ability to finish a 161-km race might be differentiated by metabolic attributes via LT measurements. Runners should not neglect the importance of the long runs and should incorporate cross-training to provide additional stimuli to the body while allowing the running muscles to recover from fatigue.
Do Envious CEOs Cause Merger Waves?

We develop a theory which shows that merger waves can arise even when the shocks that precipitated the initial mergers in the wave are idiosyncratic. The analysis predicts that the earlier acquisitions produce higher bidder returns, involve smaller targets, and result in higher compensation gains for the acquirer's top management team than the later acquisitions in the wave. We find strong empirical support for these predictions. The model also generates additional predictions, some of which remain to be tested. The Author 2009. Published by Oxford University Press on behalf of The Society for Financial Studies. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org. , Oxford University Press.