Miracle-dz/UniFAR-FTUs huggingface dataset:
Unusual report of non-syndromic permanent unilateral mandibular canine agenesis

Nonsyndromic unilateral permanent canine agenesis, particularly in the lower jaw, is an infrequent clinical observation that has occasionally been reported in the scientific literature. The main aim of the present case report and study is to give insights into the clinical features and genetic information of a nonsyndromic patient affected by unilateral lower canine agenesis and her relatives. A young girl of 9-year-old with a Class II skeletal malocclusion, sella turcica bridging, and severe overjet but no other dental anomalies is described. No associations were found with other types of dental agenesis and previously described genetic variations of the CTNNB1 gene. The possibility of a novel genetic locus should be considered as a possible genetic etiology for this extremely rare condition in a nonsyndromic patient. Based on scientific literature written in English, the present clinical case is one of the first reports to describe a nonsyndromic permanent unilateral mandibular canine agenesis.
Schützenberger Symmetries in Network Structures

: It is known that the set of all networks of ﬁxed order form a semigroup. This fact provides for the Green’s L , R , H and D equivalence classiﬁcations of all such networks. These classiﬁcations reveal certain structural invariants common to all networks within a Green’s equivalence class and enables the computation of the associated invariant preserving symmetries that transform a network into another network within a Green’s equivalence class. Here, the notion of Schützenberger symmetries in network structures is introduced. These are computable symmetries which transform any network within an H -equivalence class into another network within that class in a manner that preserves the associated structural invariants. Useful applications of Schützenberger symmetries include enabling the classiﬁcation and analysis of biological network data, identifying important relationships in social networks, and understanding the consequences of link reconﬁguration in communication and sensor networks.
Utilization of institutional rehabilitation service in pediatric patients with disability in Southwest Rajasthan

Background: Rehabilitating disabled child maximizes functional independence, thereby, enhancing the quality of life and better community participation. Utilization of rehabilitation services is a significant issue in developing countries like India. This study aims to observe the pattern of utilization of institutional rehabilitation services by pediatric patients with disability. Methods: This was an observational study (descriptive cross-sectional study) conducted at Department of Physical Medicine and Rehabilitation in a tertiary care set-up. Descriptive data from an ongoing study involving children with and without developmental delay (DD) over 1 year were collected in terms of age, gender, distance from the institute, diagnosis, and frequency of visit. Utilization pattern for rehabilitation services among pediatric patients was analyzed with respect to diagnosis and frequency of visit under each diagnosed category. The demographic variable of age, gender, and distance from the institute was further correlated to frequency of visit. IBM SPSS statistics 22 was used for descriptive statistical analysis and correlation of variables. Results: Of 464 disabled children using rehabilitation service, data for 399 (M: 255, F: 144) children were complete with age ranging from 3 months to 18 years and distance from 1 km to 600 km from institute. There were 330 children with DD and 69 in non-DD category. Two hundred and sixty-eight cases used one-time consultancy, 86 preferred intermittent services, and 45 patients were regular. Negligible correlation with a trend toward negative values was observed between frequency of service utilization and distance (Rho = −0.139 Sig. = 0.006, at 0.01 level) and between age and utilization frequency (Rho = −0.074, Sig = 0.140). Conclusions: The study showed that children with DD were main utilizers of rehabilitation services. Nearly 67% of disabled children utilized services only once with a trend toward younger age group and those nearer to institute were noted.
Speech Is Silver, Nonverbal Behavior Is Gold: How Implicit Partner Evaluations Affect Dyadic Interactions in Close Relationships

Growing evidence suggests that the seeds of relationship decay can be detected via implicit partner evaluations even when explicit evaluations fail to do so. However, little is known about the concrete daily relational processes that explain why these gut feelings are such important determinants of relationships’ long-term outcomes. The present integrative multimethod research yielded a novel finding: that participants with more positive implicit partner evaluations exhibited more constructive nonverbal (but not verbal) behavior toward their partner in a videotaped dyadic interaction. In turn, this behavior was associated with greater satisfaction with the conversation and with the relationship in the following 8-day diary portion of the study. These findings represent a significant step forward in understanding the crucial role of automatic processes in romantic relationships. Together, they provide novel evidence that relationship success appears to be highly dependent on how people spontaneously behave in their relationship, which may be ultimately rooted in their implicit partner evaluations.
Transfer and Multi-Task Learning for Noun–Noun Compound Interpretation

In this paper, we empirically evaluate the utility of transfer and multi-task learning on a challenging semantic classification task: semantic interpretation of noun–noun compounds. Through a comprehensive series of experiments and in-depth error analysis, we show that transfer learning via parameter initialization and multi-task learning via parameter sharing can help a neural classification model generalize over a highly skewed distribution of relations. Further, we demonstrate how dual annotation with two distinct sets of relations over the same set of compounds can be exploited to improve the overall accuracy of a neural classifier and its F1 scores on the less frequent, but more difficult relations.
Clinical manifestations of dengue in relation to dengue serotype and genotype in Malaysia: A retrospective observational study

Background Malaysia experienced an unprecedented dengue outbreak from the year 2014 to 2016 that resulted in an enormous increase in the number of cases and mortality as compared to previous years. The causes that attribute to a dengue outbreak can be multifactorial. Viral factors, such as dengue serotype and genotype, are the components of interest in this study. Although only a small number of studies investigated the association between the serotype of dengue virus and clinical manifestations, none of these studies included analyses on dengue genotypes. The present study aims to investigate dengue serotype and genotype-specific clinical characteristics among dengue fever and severe dengue cases from two Malaysian tertiary hospitals between 2014 and mid-2017. Methodology and principal findings A total of 120 retrospective dengue serum specimens were subjected to serotyping and genotyping by Taqman Real-Time RT-PCR, sequencing and phylogenetic analysis. Subsequently, the dengue serotype and genotype data were statistically analyzed for 101 of 120 corresponding patients’ clinical manifestations to generate a descriptive relation between the genetic components and clinical outcomes of dengue infected patients. During the study period, predominant dengue serotype and genotype were found to be DENV 1 genotype I. Additionally, non-severe clinical manifestations were commonly observed in patients infected with DENV 1 and DENV 3. Meanwhile, patients with DENV 2 infection showed significant warning signs and developed severe dengue (p = 0.007). Cases infected with DENV 2 were also commonly presented with persistent vomiting (p = 0.010), epigastric pain (p = 0.018), plasma leakage (p = 0.004) and shock (p = 0.038). Moreover, myalgia and arthralgia were highly prevalent among DENV 3 infection (p = 0.015; p = 0.014). The comparison of genotype-specific clinical manifestations showed that DENV 2 Cosmopolitan was significantly common among severe dengue patients. An association was also found between genotype I of DENV 3 and myalgia. In a similar vein, genotype III of DENV 3 was significantly common among patients with arthralgia. Conclusion The current data contended that different dengue serotype and genotype had caused distinct clinical characteristics in infected patients.
On Being Told How We Feel

Algorithms and sensors are increasingly deployed for highly personal aspects of our everyday lives. Recent work suggests people have imperfect understanding of system outputs, often assuming sophisticated capabilities and deferring to feedback. We explore how people construe algorithmic interpretations of emotional data in personal informatics systems. A survey (n=188) showed strong interest in automatic stress and emotion tracking, but many respondents expected these systems to provide objective measurements for their emotional experiences. A second study examined how algorithmic sensor feedback influences emotional self-judgments, by comparing three system framings of physiological ElectroDermal Activity data (EDA): Positive ("alert and engaged"), Negative ("stressed"), and Control (no frame) in a mixed-methods study with 64 participants. Despite users reporting strategies to test system outputs, users still deferred to feedback and their perceived emotions were significantly influenced by feedback frames. Some users overrode personal judgments, believing the system had access to privileged information about their emotions. Based on these findings, we explore design implications for personal informatics including risks of users trusting systems that seemingly "unlock" hidden aspects of the self. We propose design approaches that provide opportunities for future emotion-monitoring systems to exploit these framing effects, and for users to more actively construe emotional states.
Diarrhoeagenic Escherichia coli and Escherichia albertii in Brazil: pathotypes and serotypes over a 6-year period of surveillance

Abstract Diarrhoeagenic Escherichia coli (DEC) is a leading cause of infectious diarrhoea worldwide. In recent years, Escherichia albertii has also been implicated as a cause of human enteric diseases. This study describes the occurrence of E. coli pathotypes and serotypes associated with enteric illness and haemolytic uremic syndrome (HUS) isolated in Brazil from 2011 to 2016. Pathotypes isolated included enteropathogenic E. coli (EPEC), enteroaggregative E. coli (EAEC), enterotoxigenic E. coli (ETEC), enteroinvasive E. coli (EIEC) and Shiga toxin-producing E. coli (STEC). PCR of stool enrichments for DEC pathotypes was employed, and E. albertii was also sought. O:H serotyping was performed on all DEC isolates. A total of 683 DEC and 10 E. albertii strains were isolated from 5047 clinical samples. The frequencies of DEC pathotypes were 52.6% (359/683) for EPEC, 32.5% for EAEC, 6.3% for ETEC, 4.4% for EIEC and 4.2% for STEC. DEC strains occurred in patients from 3 months to 96 years old, but EPEC, EAEC and STEC were most prevalent among children. Both typical and atypical isolates of EPEC and EAEC were recovered and presented great serotype heterogeneity. HUS cases were only associated with STEC serotype O157:H7. Two E. albertii isolates belonged to serogroup O113 and one had the stx2f gene. The higher prevalence of atypical EPEC in relation to EAEC in community-acquired diarrhoea in Brazil suggests a shift in the trend of DEC pathotypes circulation as previously EAEC predominated. This is the first report of E. albertii isolation from active surveillance. These results highlight the need of continuing DEC and E. albertii surveillance, as a mean to detect changes in the pattern of pathotypes and serotypes circulation and provide useful information for intervention and control strategies.
Thumb domains of the three epithelial Na+ channel subunits have distinct functions

The epithelial Na+ channel (ENaC) possesses a large extracellular domain formed by a β-strand core enclosed by three peripheral α-helical subdomains, which have been dubbed thumb, finger, and knuckle. Here we asked whether the ENaC thumb domains play specific roles in channel function. To this end, we examined the characteristics of channels lacking a thumb domain in an individual ENaC subunit (α, β, or γ). Removing the γ subunit thumb domain had no effect on Na+ currents when expressed in Xenopus oocytes, but moderately reduced channel surface expression. In contrast, ENaCs lacking the α or β subunit thumb domain exhibited significantly reduced Na+ currents along with a large reduction in channel surface expression. Moreover, channels lacking an α or γ thumb domain exhibited a diminished Na+ self-inhibition response, whereas this response was retained in channels lacking a β thumb domain. In turn, deletion of the α thumb domain had no effect on the degradation rate of the immature α subunit as assessed by cycloheximide chase analysis. However, accelerated degradation of the immature β subunit and mature γ subunit was observed when the β or γ thumb domain was deleted, respectively. Our results suggest that the thumb domains in each ENaC subunit are required for optimal surface expression in oocytes and that the α and γ thumb domains both have important roles in the channel's inhibitory response to external Na+. Our findings support the notion that the extracellular helical domains serve as functional modules that regulate ENaC biogenesis and activity.
Reference Limits for Outlier Analyses in Randomized Clinical Trials

Background Reference limits used in clinical medicine to screen and manage patients are typically developed nonparametrically using reference values from a limited number of healthy subjects using a 95th percentile reference interval. We have evaluated alternative methods of computation and the resulting limits for use in the analyses of treatment-emergent outliers in clinical trials. Methods We developed a set of alternative reference limits for 38 laboratory analytes based on alternative statistical methods and assessed their relative performance in clinical trial analysis. Performance assessment was based on the clinical credibility of the limits, inferential statistical performance, consideration of incidences for the test drug and control (placebo) in cases where the drug was reasonably believed to be associated with a change in an analyte (positive cases), and in cases where prior analyses failed to demonstrate a change associated with the drug (negative cases). Results Based on consideration of these cases, no single method resulted in optimal limits for all cases considered. However, with the limits developed using clinical trial subjects’ values at baseline as reference values, excluding outliers, the robust method and the 98th percentile interval appeared to produce optimal limits across the greatest number of cases considered. Conclusion Although no single method of limit computation will result in optimal limits for all outlier analyses for all analytes across all clinical trials, the 98th percentile reference interval robust limits based on clinical trial reference values appeared superior to multiple alternatives considered for such analyses.
Early‐SEPs’ amplitude reduction is reliable for poor‐outcome prediction after cardiac arrest?

The bilateral absence of cortical Somatosensory Evoked Potentials (SEPs), after cardiac arrest (CA), is a high reliable predictor of poor outcome but it is present in no more than 40% of patients. An amplitude reduction of cortical SEPs was found in about 30% of subjects, but few papers analysed its prognostic significance. The aim of our study is to identify a value of SEP amplitude reduction below which all the CA patients had poor outcome and the relationship between SEP and Electroencephalogram (EEG) patterns.
Evaluating Source Data Verification as a Quality Control Measure in Clinical Trials

TransCelerate has developed a risk-based monitoring methodology that transforms clinical trial monitoring from a model rooted in source data verification (SDV) to a comprehensive approach leveraging cross-functional risk assessment, technology, and adaptive on-site, off-site, and central monitoring activities to ensure data quality and subject safety. Evidence suggests that monitoring methods that concentrate on what is critical for a study and a site may produce better outcomes than do conventional SDV-driven models. This article assesses the value of SDV in clinical trial monitoring via a literature review, a retrospective analysis of data from clinical trials, and an assessment of major and critical findings from TransCelerate member company internal audits. The results support the hypothesis that generalized SDV has limited value as a quality control measure and reinforce the value of other risk-based monitoring activities.
CBER’s Experience With Adaptive Design Clinical Trials

There is considerable interest among pharmaceutical and other medical product developers in adaptive clinical trials, in which knowledge learned during the course of a trial affects ongoing conduct or analysis of the trial. When the FDA released a draft Guidance document on adaptive design clinical trials in early 2010, expectations were high that it would lead to an increase in regulatory submissions involving adaptive design features, particularly for confirmatory trials. A 6-year (2008–2013) retrospective survey was performed within the Center for Biologics Evaluation and Research (CBER) at the FDA to gather information regarding the submission and evaluation of adaptive design trial proposals. We present an up-to-date summary of adaptive design proposals seen in CBER and provide an overview of our experiences. We share our concerns regarding the statistical issues and operational challenges raised during the review process for adaptive design trials. We also provide general recommendations for developing proposals for such trials. Our motivation in writing this paper was to encourage the best study design proposals to be submitted to CBER. Sometimes these can be adaptive, and sometimes a simpler design is most efficient.
Career Ambition as a Way of Understanding the Relation Between Locus of Control and Self-Perceived Employability Among Psychology Students

Employability is one of the core concepts for the future career. Students’ self-perceived employability is the concept that connects students’ present context of education with their future professional engagement. Students’ self-perceived employability is defined as the capacity to gain and keep employment in line with their future qualification level. Locus of control is a concept that explains where the person situates the causation of various life events. It is found that internal locus of control was related to different aspects of career success. Career ambition is regarded as a proxy for students’ future career success. Both internal locus of control and ambition lead to proactive behaviors that are relevant for employability and consequently result in securing a sustainable job. The aim of this mixed-method study was to investigate the relations among locus of control, ambition and students’ self-perceived employability. Firstly, we tested mediating role of career ambition in relation of internal locus of control and students’ self-perceived employability, then we turned to qualitative analysis of students’ career self-SWOT analyses in order to deepen and enrich quantitative findings. The sample consisted of 124 undergraduate psychology students that filled out Levenson’s Internality subscale from IPC locus of control scale, Rothwell et al. (2008) Ambition subscale, and three items extracted from the Self-perceived employability subscale. Majority of the survey participants (N = 100) filled out personal career SWOT analysis. The mediation analysis showed that career ambition had a mediating role in the relation between the locus of control and employability. Students perceived personal capabilities and ambition as internal strengths and lack of ambition as a major internal weakness. As external opportunities students perceived various chances for developing professional skills, whereas as external threats they perceived limited opportunities in job market. In order to support university students to develop employability and future career success, university curricula should support developing future work skills that, in addition to functional competences and personal resources, entail career ambition, ways of utilizing external opportunities and dealing with job market threats.
Efficacy of diode laser irradiation during dental bleaching in preventing enamel damage caused by bleaching

Background: Evidence on the protecting effect of laser on bleached enamel is scarce and controversial. Therefore, we aimed to test for the first time whether different wavelengths of diode laser (810 and 980 nm) can prevent enamel surface corrosion. We also tested for the first time whether such therapeutic effects of laser are limited to specific “laser-activated” bleaching gels or both conventional and laser-activated gels. Materials and Methods: In this qualitative experimental study, ten intact human teeth were randomly assigned to five Groups. They were sectioned into twenty buccal/lingual pieces. The groups were: (1) laser-activated gel + 810 nm laser, (2) laser-activated gel + 980 nm laser, (3) conventional gel + 810 nm laser, (4) conventional gel + 980 nm laser, (5) conventional gel only, and (6) laser-activated gel - no irradiation. Buccal sections in each group were subjected to bleaching (according to the stated protocols), and later subjected to field-emission scanning electron microscopy (SEM) and X-ray diffraction (XRD). The lingual pieces were used as “before-treatment” negative controls for XRD. Results: XRD showed an increase in the mineral phase and crystallinity of the enamel in all bleaching groups. This was stronger in the laser-irradiated groups with conventional bleaching agent. SEM showed a complete etched surface in the positive control groups (i.e., bleached using conventional agent). However, all four laser groups had almost intact surfaces. Conclusion: This study showed the positive effect of diode laser irradiation at 810 nm or 980 nm wavelengths on the prevention of bleaching damage, irrespective of the activation mechanism of the bleaching gel in use.
A feasibility study on identifying drinking-related contents in Facebook through mining heterogeneous data

Binge drinking is a severe health problem faced by many US colleges and universities. College students often post drinking-related text and images on social media, portraying their alcohol use as socially desirable. In this project, we investigated the feasibility of mining the heterogeneous data (e.g. text, images, and videos) on Facebook to identify drinking-related contents. We manually annotated 4266 posts during 21 October 2011 and 3 November 2014 from “I’m Shmacked” group on Facebook, where 511 posts were drinking-related. Our machine learning models show that by combining heterogeneous data types, we were able to identify drinking-related posts with an F1-score of 0.81. Prediction models built on text data were more reliable compared to those built on image and video data for predicting drinking-related contents. As the first step of our efforts in this direction, this feasibility study showed promise toward unleashing the potential of mining social media to identify students who binge drink.