Miracle-dz/UniFAR-FTUs huggingface dataset:
A Taxonomy of Evaluation Methods for Information Systems Artifacts

Abstract Artifacts, such as software systems, pervade organizations and society. In the field of information systems (IS) they form the core of research. The evaluation of IS artifacts thus represents a major issue. Although IS research paradigms are increasingly intertwined, building and evaluating artifacts has traditionally been the purview of design science research (DSR). DSR in IS has not reached maturity yet. This is particularly true of artifact evaluation. This paper investigates the “what” and the “how” of IS artifact evaluation: what are the objects and criteria of evaluation, the methods for evaluating the criteria, and the relationships between the “what” and the “how” of evaluation? To answer these questions, we develop a taxonomy of evaluation methods for IS artifacts. With this taxonomy, we analyze IS artifact evaluation practice, as reflected by ten years of DSR publications in the basket of journals of the Association for Information Systems (AIS). This research brings to light important relationships between the dimensions of IS artifact evaluation, and identifies seven typical evaluation patterns: demonstration; simulation- and metric-based benchmarking of artifacts; practice-based evaluation of effectiveness; simulation- and metric-based absolute evaluation of artifacts; practice-based evaluation of usefulness or ease of use; laboratory, student-based evaluation of usefulness; and algorithmic complexity analysis. This study also reveals a focus of artifact evaluation practice on a few criteria. Beyond immediate usefulness, IS researchers are urged to investigate ways of evaluating the long-term organizational impact and the societal impact of artifacts.
Diabetic wound healing in a MMP9‐/‐ mouse model

Reduced mobilization of endothelial progenitor cells (EPCs) from the bone marrow (BM) and impaired EPC recruitment into the wound represent a fundamental deficiency in the chronic ulcers. However, mechanistic understanding of the role of BM‐derived EPCs in cutaneous wound neovascularization and healing remains incomplete, which impedes development of EPC‐based wound healing therapies. The objective of this study was to determine the role of EPCs in wound neovascularization and healing both under normal conditions and using single deficiency (EPC) or double‐deficiency (EPC + diabetes) models of wound healing. MMP9 knockout (MMP9 KO) mouse model was utilized, where impaired EPC mobilization can be rescued by stem cell factor (SCF). The hypotheses were: (1) MMP9 KO mice exhibit impaired wound neovascularization and healing, which are further exacerbated with diabetes; (2) these impairments can be rescued by SCF administration. Full‐thickness excisional wounds with silicone splints to minimize contraction were created on MMP9 KO mice with/without streptozotocin‐induced diabetes in the presence or absence of tail‐vein injected SCF. Wound morphology, vascularization, inflammation, and EPC mobilization and recruitment were quantified at day 7 postwounding. Results demonstrate no difference in wound closure and granulation tissue area between any groups. MMP9 deficiency significantly impairs wound neovascularization, increases inflammation, decreases collagen deposition, and decreases peripheral blood EPC (pb‐EPC) counts when compared with wild‐type (WT). Diabetes further increases inflammation, but does not cause further impairment in vascularization, as compared with MMP9 KO group. SCF improves neovascularization and increases EPCs to WT levels (both nondiabetic and diabetic MMP9 KO groups), while exacerbating inflammation in all groups. SCF rescues EPC‐deficiency and impaired wound neovascularization in both diabetic and nondiabetic MMP9 KO mice. Overall, the results demonstrate that BM‐derived EPCs play a significant role during wound neovascularization and that the SCF‐based therapy with controlled inflammation could be a viable approach to enhance healing in chronic diabetic wounds.
Annexin A8 Is a Prognostic Marker and Potential Therapeutic Target for Pancreatic Cancer

Objectives We investigated whether annexin A8 (A-A8), a Ca2+-binding protein overexpressed in pancreatic cancer, plays a role in cell growth and migration and investigated its association with pancreatic cancer prognosis. Methods Clinicopathological features and associations between increased A-A8 expression (determined by immunohistochemistry) and histologic grade were studied in a tissue microarray of 90 patients with resected stage I/II pancreatic cancer. We investigated A-A8’s effect on cell migration, proliferation, and colony formation in 2 pancreatic cancer cells (BXPC-3 and Panc-1). Statistical analyses included Fisher exact test, t test, analysis of variance, and survival analysis. Results Western blot showed increased A-A8 expression in human pancreatic cancer cells, with A-A8 knockdown in BXPC-3 and Panc-1 cells demonstrating decreased cell viability (P = 0.017 and P = 0.001), migration (2.5 vs 0.9 mm and 1.6 vs 1 mm at 96 hours; P = 0.048 and P = 0.004), and colony formation (approximately 75% and 40% from scramble; P ⩽ 0.01), respectively. In our tissue microarray, A-A8 expression increased 5.9-fold (r = 0.31; P = 0.019) from low- to high-grade tumors, correlating with tumor grade (r = 0.23; P = 0.027). In addition, high A-A8 expression was associated with a decreased 5-year survival (P = 0.042). Conclusions Our study is the first showing that increased A-A8 expression is associated with poor prognosis in early-stage pancreatic cancer, thus supporting its further investigation as a future therapeutic target and prognostic marker.
Cervical Changes Throughout Pregnancy as Assessed by Transvaginal Sonography

Objective: To evaluate changes in cervical dimensions by transvaginal ultrasound in non-randomly selected pregnant women. Methods: This longitudinal study included 154 pregnant women undergoing transvaginal ultrasound assessment of the cervix at a mean gestational age of 12, 16, 20, 25, and 31 weeks. On each occasion, the longitudinal and anteroposterior diameters of the cervix were measured. The rate of prematurity in the series was 1.9%, and the mean gestational age at delivery was 38.7 weeks. Results: Overall, cervical length (mean 4.3 cm; 95% confidence interval 4.1-4.3) did not change significantly (P=.06), whereas the anteroposterior diameter of the cervix at its midportion shortened throughout the investigated period of gestation. Multiparous women had longer and thicker cervices than primigravidas or women with previous cesareans or first-trimester abortions. Gestational age at delivery did not correlate with cervical dimensions at any stage of pregnancy. Conclusions: The cervix undergoes a change in shape from cylindrical to conic, more marked in primigravidas than in parous women. Women who had previous cesarean deliveries had cervical characteristics similar to primigravidas; therefore, it appears that mechanical, rather than hormonal, factors have a greater effect in determining changes of cervical dimensions throughout pregnancy. (Obstet Gynecol 1994;84:960-4)
Association of CD 14 C 159 T polymorphism with atopic asthma susceptibility in children from Southeastern China : a case-control study

CD14 is involved in primary immune and inflammatory responses. The -159 C/T variation in the CD14 gene plays an important role in regulating CD14 expression and has been associated with the susceptibility to various diseases, including allergies. In this study, we examined the association between the C-159T polymorphism and atopic asthma susceptibility in children from Southeastern China. The study population included 746 unrelated children of Chinese Han nationality (362 patients with atopic asthma and 384 healthy controls). CD14 gene polymorphisms were identified by direct sequencing of polymerase chain reaction products. Total immunoglobulin E (IgE) levels in human serum samples were determined using an enzymelinked immunosorbent assay. Individuals carrying the TT genotypes for rs2569190 were significantly associated with an increased risk of atopic asthma compared with those carrying the wild-type homozygous CC genotypes [adjusted odds ratio (OR) by gender and age, from 1.075-
Enhanced Biological Phosphorus Removal and Recovery

Activated sludge systems designed for enhanced nutrient removal are based on the principle of altering anaerobic and aerobic conditions for growth of microorganisms with a high capacity of phosphorus accumulation. Most often, filamentous bacteria constitute a component of the activated sludge microflora. The filamentous microorganisms are responsible for foam formation and activated sludge bulking. The results obtained confirm unanimously that the filamentous bacteria have the ability of phosphorus uptake and accumulation as polyphosphates. Hydrodynamic disintegration of the foam microorganisms results in the transfer of phosphorus and metal cations and ammonium‐nitrogen into the liquid phase. It was demonstrated that the disintegration of foam permits the removal of a portion of the nutrients in the form of struvite.
The prothrombin G20210A polymorphism in patients with myocardial infarction

To investigate a possible association between the human prothrombin gene G20210A polymorphism and coronary artery thrombosis, we screened 172 consecutive patients with ischaemic heart disease admitted for coronary arteriography. The patients were divided into two groups on the basis of their clinical history and examination of their hospital records: 66 patients with a definite previous myocardial infarction, and 106 with angina-like chest pain but no evidence of myocardial infarction. The overall frequency of the G20210A polymorphism was 0.011, four out of the 172 patients being heterozygous for the mutation. The allelic frequency was 0.015 in the group with myocardial infarction and 0.009 in the group without myocardial infarction (P = 0.622). The results of this study suggest that the single nucleotide polymorphism at position 20210 of the prothrombin gene is unlikely to be a risk factor for coronary thrombosis.
Lysogeny and prophage induction in coastal and offshore bacterial communities

The influence of solar radiation and hydrogen peroxide on induction of lysogens, and the resulting effect on bacteriophage production and bacterial mortality was investigated for coastal and oceanic manne bacterial conlmunities at 6 stations in the western Gulf of Mexico. The percentage of lysogenic cells induced by mitomycin C was also determined. Solar radiation and hydrogen peroxide were not as effective as mitomycin C at inducing phage production. The burst size of cells induced by mitomycin C was estimated by transmission electron microscopy, assuming that cells completely filled with viral particles were on the verge of bursting. The smallest estimates of burst size were associated with oligotrophic oceanic stations and ranged from 15 to 28 viruses produced per lyhc event, whde in more productive coastal waters the estimated burst sizes ranged from 33 to 64. The mitomycin Cinduced phage production and burst size were used to estimate the number of lysogenic bacterial cells. On average, the percentage of inducible lysogens was higher at offshore (1.5 to 11.4 %) than at coastal (0.8 to 2.2 %) stations. However, with the exception of 1 station, less than 5 % of the bacteria could be induced to produce phage, suggesting that lysogens only occasionally comprised a significant component of these bacterial communities. The proportion of lysogens that could be induced by sunlight, relative to those that could be induced by rnitomycin C, was lower at oceanic than coastal stations. This implies that prophages in optically transparent offshore waters were more resistant to induction by solar radiation, or that most lysogens that could be triggered by sunlight were already induced. Based on a steady-state model, induction of lysogenic bacteria by solar radiation or hydrogen peroxide could result in between 0 and 3 5 % or 0.9 and 3.4 % of the total bacterial mortality, respectively. Our results imply that solar radiation and hydrogen peroxide induced lysogenic phage production were not an ~mportant source of phage production or bacterial mortality in offshore or coastal waters of the western Gulf of Mexico.
Temporal changes in rock uplift rates of folds in the foreland of the Tian Shan and the Pamir from geodetic and geologic data

Understanding the evolution of continental deformation zones relies on quantifying spatial and temporal changes in deformation rates of tectonic structures. Along the eastern boundary of the Pamir‐Tian Shan collision zone, we constrain secular variations of rock uplift rates for a series of five Quaternary detachment‐ and fault‐related folds from their initiation to the modern day. When combined with GPS data, decomposition of interferometric synthetic aperture radar time series constrains the spatial pattern of surface and rock uplift on the folds deforming at decadal rates of 1–5 mm/yr. These data confirm the previously proposed basinward propagation of structures during the Quaternary. By fitting our geodetic rates and previously published geologic uplift rates with piecewise linear functions, we find that gradual rate changes over >100 kyr can explain the interferometric synthetic aperture radar observations where changes in average uplift rates are greater than ~1 mm/yr among different time intervals (~101, 104–5, and 105–6 years).
Diffusion of Xenon and Nitrous Oxide into the Bowel

Background Nitrous oxide diffuses easily from blood into air filled spaces. Xenon is also a relatively insoluble gas, like nitrous oxide. Therefore, the authors measured xenon diffusion into obstructed bowel segments during xenon anesthesia and compared this with nitrous oxide and nitrogen diffusion. Methods Twenty-one pentobarbital-anesthetized pigs were randomly assigned to three groups to receive either xenon–oxygen, nitrous oxide–oxygen, or nitrogen–oxygen (75%–25%), respectively. In each animal, four bowel segments of 15-cm length were isolated. A pressure-measuring catheter was inserted into the lumen, and 30 ml of room air was injected into the segments. Anesthesia with the selected gas mixture was performed for 4 h. Pressure in the segments was measured continuously. The volume of gaseous bowel content was measured on completion of the study. Results The median volume of bowel gas in animals breathing nitrous oxide was 88.0 ml as compared with 39.0 ml with xenon anesthesia and 21.5 ml in the nitrogen–oxygen group. After 4 h of anesthesia, the intraluminal pressures in the nitrous oxide group were found to be significantly greater than in the control group and in the xenon group. Conclusions The amount of diffused gas was significantly lower during xenon anesthesia than with nitrous oxide anesthesia but greater than with controls. Blood solubility can therefore be regarded as an important factor influencing gas diffusion into air filled cavities.
Determination of structure parameters in strong-field tunneling ionization theory of molecules

In the strong field molecular tunneling ionization theory of Tong et al. [Phys. Rev. A 66, 033402 (2002)], the ionization rate depends on the asymptotic wave function of the molecular orbital from which the electron is removed. The orbital wave functions obtained from standard quantum chemistry packages in general are not good enough in the asymptotic region. Here we construct a one-electron model potential for several linear molecules using density functional theory. We show that the asymptotic wave function can be improved with an iteration method and after one iteration accurate asymptotic wave functions and structure parameters are determined. With the new parameters we examine the alignment-dependent tunneling ionization probabilities for several molecules and compare with other calculations and with recent measurements, including ionization from inner molecular orbitals.
HIF-1A, pimonidazole, and iododeoxyuridine to estimate hypoxia and perfusion in human head-and-neck tumors.

PURPOSE Tumor hypoxia measured by microelectrodes has been shown to indicate poor patient outcome. Here we investigated four potentially more widely applicable immunohistochemical parameters of tumor oxygenation and perfusion in human head-and-neck tumors. METHODS Twenty patients with squamous cell carcinomas of the head and neck treated with primary surgery were injected with pimonidazole and IdUrd the evening before operation. Consecutive paraffin-embedded sections were stained for blood vessels, pimonidazole, IdUrd, and HIF-1alpha. IdUrd labeling and Ki-67 labeling around individual blood vessels were scored. The spatial relationship between HIF-1alpha and pimonidazole was studied, as well as the distribution of both markers as a function of distance from the nearest blood vessel. RESULTS Measurement of all four parameters (diffusion-limited fraction, pimonidazole fraction, HIF-1alpha fraction, IdUrd-negative vessels) was feasible, and a significant difference between tumors was found for all parameters. IdUrd-labeled cells were absent around some vessels, indicating lack of perfusion, because these regions were positive for Ki-67. There was a positive correlation between diffusion-limited fraction and pimonidazole area for all images from all tumors, although no correlation for mean values per tumor. Colocalization of pimonidazole and HIF-1alpha was low (0.02%-25%). Most expression profiles showed a more homogenous distribution for HIF-1alpha than pimonidazole. There was no significant correlation between the pimonidazole and HIF-1alpha fractions in the 10 tumors studied. CONCLUSIONS Simultaneous immunohistochemical measurements related to hypoxia and perfusion are feasible (and easily applicable) in resected human tumors. The different geographic distributions of HIF-1alpha and pimonidazole indicate that HIF-1alpha might not be suitable as a marker for chronic hypoxia. Each parameter will be correlated with outcome in a larger ongoing study on head-and-neck tumors treated with surgery with or without postoperative radiotherapy.
A randomized comparison of group cognitive‐behavioural therapy and group psychoeducation in acute patients with schizophrenia: outcome at 24 months

Objective: We compared the effects of a brief group cognitive‐behavioural therapy (CBT) and a group psychoeducational (PE) programme in acute patients with schizophrenia 2 years after treatment. At 6‐month follow‐up, the CBT group had shown significantly less re‐hospitalization rates and on a descriptive level higher compliance with medication.
The genetics of keratoconus

Keratoconus is a relatively common, bilateral, non‐ inflammatory corneal ectasia. The aetiology of this condition is probably multifactorial, or it represents the final common pathway for a variety of different pathological processes. Although a familial history is present only in a minority of cases, one of the major aetiological factors is certainly genetic. This is evidenced by: the condition's familial inheritance; its discordance between monozygotic and dizygotic twins; and its association with other known genetic disorders such as Down's and Marfan's syndromes. In the keratoconic cornea, a possible genetic predisposition to increased sensitivity to apoptotic mediators by keratocytes has also been hypothesized. Differences in prevalence between ethnic groups have been identified. Recent advances in computerized topographic diagnostic techniques for keratoconus, including forme fruste keratoconus, enables higher accuracy in delineating abnormal from normal, and helps define study populations for genetic linkage studies. However, genetic heterogeneity and the phenotypic diversity of keratoconus means that genetic analysis continues to be a complex process. None the less, it is foreseeable that over the next decade, improved diagnostic techniques, in combination with molecular genetics, may reveal conclusive data on the precise nature of the genetic inheritance of keratoconus in specific populations. This review considers the evidence that suggests keratoconus is primarily an inherited condition, and examines research strategies aimed at unveiling the genetic predisposition, and the enigma of environmental influences on its phenotypic expression.
The functional magnetic resonance imaging-based verbal fluency test in obsessive–compulsive disorder

Clinical use of functional magnetic resonance imaging (fMRI) in obsessive–compulsive disorder (OCD) is limited by a relative absence of fMRI task development, standardization, and normative performance databases. We investigated the fMRI-based verbal fluency test (f-VFT) by quantitatively evaluating brain activation patterns in OCD participants (8 females and 4 males) compared with a normative database (16 females and 16 males). At the group level, OCD participants and references had highly similar activation in left-hemisphere language regions, including the precentral/premotor cortex, thalamus, basal ganglia, and inferior frontal gyrus/frontal operculum. At the interindividual level, however, the OCD group had highly variable activation patterns in the dorsal and ventral regions of the pre-supplementary motor area (pre-SMA) that may correspond with differences in demographic and clinical variables. Further, there were significant correlations in the OCD participants between pre-SMA dorsal and ventral activation and between dorsal pre-SMA activation and perfectionism. Our findings suggest considerable functional anatomical overlap in left-hemisphere language regions between OCD participants and references but significantly higher pre-SMA interindividual variability in OCD compared to the reference group that may be relevant in clinical fMRI application and the theoretical understanding of OCD.
Why Are Inflation and Real Interest Rates So Low ? A Mechanism of Low and Floating Real Interest and Inflation Rates

Real interest and inflation rates have been very low in many industrialized countries since the Great Recession. In this paper, a mechanism of low and floating real interest and inflation rates is examined based on the concept a “Nash equilibrium of a Pareto inefficient path” and the law of motion for trend inflation. I show that, because the link between the marginal product of capital and the real interest rate is severed on this path, the real interest rate loses its anchor and therefore floats. In addition, the inflation rate floats together with the real interest rate. There are, however, upper and lower bounds of the floating rates. It is also likely that the real interest rate floats below the marginal product of capital on this path and the inflation rate floats below the target rate of inflation. JEL Classification: E21, E22, E31, E32, E43, E52, E62, G21
Bayesian Model Selection for Heteroskedastic Models

It is well known that volatility asymmetry exists in financial markets. This paper reviews and investigates recently developed techniques for Bayesian estimation and model selection applied to a large group of modern asymmetric heteroskedastic models. These include the GJR-GARCH, threshold autoregression with GARCH errors, TGARCH, and double threshold heteroskedastic model with auxiliary threshold variables. Further, we briefly review recent methods for Bayesian model selection, such as, reversible-jump Markov chain Monte Carlo, Monte Carlo estimation via independent sampling from each model, and importance sampling methods. Seven heteroskedastic models are then compared, for three long series of daily Asian market returns, in a model selection study illustrating the preferred model selection method. Major evidence of nonlinearity in mean and volatility is found, with the preferred model having a weighted threshold variable of local and international market news.