Miracle-dz/UniFAR-FTUs huggingface dataset:
Time dependent of epigenetic effect of disulfiram on tumor suppressor gene of RASSF1A in Hela cancer cell line

Introduction: Cervical cancer is the third most common tumor among women. Surgery, radiotherapy, and chemotherapy are common treatments, however high stage tumors have frequently poor prognosis. Nowadays, the epigenetic reversion introduced as an efficient strategy of treatment of cervical cancer. In the process, inhibitors of DNA methyltransferase (DNMT) induce re-expression of tumor suppressor genes. Among these inhibitors, disulfiram (DSF) has been suggested as non-nucleoside analogous. In this research, we evaluated the epigenetic effect of DSF on demethylation of the tumor suppressor gene, RASSF1A, in Hela cell line. Materials and methods: Hela cells were cultured and treated with different doses from 2.5 to 37. 5µM during 24, 48 and 72 hours. MTT assay was carried out to find half maximal inhibitory concentration (IC50). The methylation specific PCR (MSP) assay was applied to evaluate methylation pattern. Results: The IC50 of DSF was determined at the 2.5, 12.5, and 15µM after72 hours. The MSP results showed partial demethylation at mentioned concentrations after 72h but unmethylated band was not observed after 24h. Conclusion: Our findings indicated that, IC50 of DSF exerted a biphasic effect in Hela cell line and at least 72 hours treatment is needed for the epigenetic reversion of DSF on RASSF1Ain Hela cell line.
Work-related well-being of South African hospital pharmacists

Orientation: Hospital pharmacists in South Africa are experiencing increased stress because of the high demand for their services, a lack of resources in hospital pharmacies, and the shortage of pharmacists in South Africa. Research purpose: The objective of this study was to investigate whether job stress and coping strategies could predict the work-related well-being (burnout and work engagement) of hospital pharmacists in South Africa. Motivation for the study: Information about the work-related well-being and coping strategies of hospital pharmacists could be used to plan individual and organisational interventions which can be used to retain them and to manage their well-being and performance. Research design, approach and method: A survey design was used. A stratified random sample ( N = 187) of pharmacists in South African hospitals was studied. The Maslach Burnout Inventory – Human Services Survey, Utrecht Work Engagement Scale, Pharmacist Stress Inventory and the COPE questionnaire were administered. Main findings: The results showed that job related stress and three coping strategies (approach coping, avoidant coping, and turning to religion) predicted burnout and work engagement of South African hospital pharmacists. Practical implications: Job stressors that are in the main responsible for the unfavourable work environment and that lead to the development of burnout amongst hospital pharmacists should be addressed. It is also important to enhance the coping capabilities of the hospital pharmacists. Contribution/value-add: The findings of this study provide insight into the factors impacting on the work-related well-being of hospital pharmacists in South Africa.
OBTAINING LISTENING COMPREHENSION BY USING VIDEO MATERIALS

The utilization of multimedia technology has given positive contributions in the implementation of teaching listening. It provides the teachers with easier and more efficient ways to facilitate listening materials and practices in the form of audio as the main important sources. However, employing audio only is considered to be not enough to assist students to comprehend the information well. The use of audio-visual materials such as videos is proposed as a better means to acquire students’ listening comprehension. The visualization of videos provides the students the ease to get better contexts, decrease the boredom, and stimulate the imagination to the more authentic situation. This paper employed causal comparative research to examine the use of audio and audiovisual materials in teaching listening, then to evaluate which one has a better result in obtaining students’ listening comprehension as viewed from genders. Keywords : video, listening comprehension, gender
Some existence results for advanced backward stochastic differential equations with a jump time

In this paper, we are interested by advanced backward stochastic differential equations (ABSDE), in a probability space equipped with a Brownian motion and a single jump process. The solution of the ABSDE is a triple (Y, Z, U) where Y is a semimartingale, Z is the diffusion coefficient and U the size of the jump. We allow the generator to depend on the future paths of the solution.
CALPIONELLID AND NANNOCONID STRATIGRAPHY AND MICROFACIES OF LIMESTONES AT THE TITHONIAN – BERRIASIAN BOUNDARY IN THE SIERRA DEL INFIERNO ( WESTERN CUBA )

1 Institute of Geological Sciences, Polish Academy of Sciences, ul. Twarda 51/55, PL-00-818 Warszawa, Poland, apszczol@twarda.pan. pl 2 Instituto de Geología y Paleontología, Vía Blanca y Prolongación de Calzada de Güines, S/N, San Miguel del Padrón, Ciudad de la Habana, Codigo Postal 11000, La Habana, Cuba, dora@igp.minbas. cu 3 Centro de Investigaciones del Petróleo, Washington 169, Cerro, Habana 12000, Cuba, santa@ceinpet.cupet. cu
The cold mode: a phenomenological model for the evolution of density perturbations in the intracluster medium

Cool cluster cores are in global thermal equilibrium but are locally thermally unstable. We study a non-linear phenomenological model for the evolution of density perturbations in the intracluster medium (ICM) due to local thermal instability and gravity. We have analysed and extended a model for the evolution of an overdense blob in the ICM. We find two regimes in which the overdense blobs can cool to thermally stable low temperatures. One for large t(cool)/t(ff) (t(cool) is the cooling time and t(ff) is the free-fall time), where a large initial overdensity is required for thermal runaway to occur; this is the regime which was previously analysed in detail. We discover a second regime for t(cool)/t(ff) less than or similar to 1 (in agreement with Cartesian simulations of local thermal instability in an external gravitational field), where runaway cooling happens for arbitrarily small amplitudes. Numerical simulations have shown that cold gas condenses out more easily in a spherical geometry. We extend the analysis to include geometrical compression in weakly stratified atmospheres such as the ICM. With a single parameter, analogous to the mixing length, we are able to reproduce the results from numerical simulations; namely, small density perturbations lead to the condensation of extended cold filaments only if t(cool)/t(ff) less than or similar to 10.
Nematicidal effect of sunn hemp Crotalaria juncea leaf residues on Meloidogyne incognita attacking tomato Solanum lycopersicum roots

Field experiments were conducted to determine the optimum application rate of sunn hemp Crotalaria juncea leaf residue in the management of Meloidogyne incognita on tomato. Sunn hemp applied at rates of 0 (control), 2, 4 and 6 kg/ha showed a varied effect on second stage juveniles of M. incognita. There were no differences in plant height and stem girth. The 6 kg/ha treatment reduced the M. incognita population by 94% compared with the control. The highest yield of tomato (168.7 kg/ha) was recorded in 6 kg/ha treatment of sunn hemp.
Skill-Biased Technical Change and the Decline in Low-Skill Wages in a Signaling Model.

Skill-biased technical change is the most frequently-cited explanation for the rise in the college education premium observed in the US over the last 30 years. However, skill-biased technical change does not necessarily explain the decline in non-college wages, the main driver of the rise in the college education premium. In this paper we introduce wealth heterogeneity into Spence’s (1973) education signaling model. We nd that under some general conditions of wealth distribution, the decline in non-college wages can be explained as a consequence of ability composition eects induced by skill-biased technical change. JEL-Classication : D82, J31, I20
Estimating epikarst water storage by time-lapse surface-to-depth gravity measurements

Abstract. The magnitude of epikarstic water storage variation is evaluated in various karst settings using a relative spring gravimeter. Gravity measurements are performed over a 1.5-year period at the surface and inside caves at different depths on three karst hydro-systems in southern France: two limestone karst systems and one dolomite karst system. We find that significant water storage variations occur in the first 10 m of karst unsaturated zone. The subsurface water storage is also evidenced by complementary magnetic resonance sounding. The comparison between sites of the depth gravity measurements with respect to net water inflow suggests that seasonal water storage depends on the lithology. The transmissive function of the epikarst on the seasonal scale has been deduced from the water storage change estimation. Long (> 6 months) and short (< 6 months) transfer times are revealed in the dolomite and in the limestone respectively.
The Impact of Arts-Based Leadership Development on Leader Mind-Set

The Problem Arts-based leadership interventions have gained a foothold in the leadership development literature; however, few studies have investigated their effectiveness. These interventions include music, drama, art, and performance and are utilized to develop dimensions of leader mind-set. The Solution In this study, an arts-based intervention (leadership drawing exercise) is evaluated. Utilizing a quasi-experimental, pre-test, post-test design, we evaluate the impact of an arts-based intervention on four dimensions of leader mind-set: emotional intelligence, leader identity, openness to experience, and feedback orientation. Leaders in the arts-based intervention showed significantly greater improvement in emotional intelligence, leader identity, and feedback orientation. The Stakeholders This article informs leadership development researchers, those making decisions about investment in leadership development and those who deliver leadership development. The article will be of interest to organizations that have to justify investment in leadership development.
Riverine Spawning by Sockeye Salmon in the Taku River, Alaska and British Columbia

Abstract Radio telemetry was used to determine the distribution of sockeye salmon Oncorhynchus nerka returning to spawn in the glacial Taku River in 1984 and 1986, and to locate and characterize spawning areas used by this species. During the study, 253 sockeye salmon were tracked as they moved upriver; 204 of these were followed to spawning areas. Only 37% of the 204 fish traveled to areas associated with lakes; the remaining 63% returned to “riverine” areas – river areas without lakes (42% to the Taku River main stem, 17% to the Nakina River, and 4% to other rivers). Sockeye salmon spawning in riverine areas used a variety of habitat types, including main-river channels, side channels, tributary streams, and upland sloughs. Most (55%) of the radio-tagged fish that returned to the Taku River main stem were tracked to side-channel spawning areas. Half of the 471 adult sockeye salmon sampled in main-stem spawning areas had migrated to sea as juveniles before their first winter. This study showed that many .
Why do forest products become less available?A pan-tropical comparison of drivers of forest-resource degradation

Forest products provide an important source of income and wellbeing for rural smallholder communities across the tropics. Although tropical forest products frequently become over-exploited, only few studies explicitly address the dynamics of degradation in response to socio-economic drivers. Our study addresses this gap by analyzing the factors driving changes in tropical forest products in the perception of rural smallholder communities. Using the poverty and environment network global dataset, we studied recently perceived trends of forest product availability considering firewood, charcoal, timber, food, medicine, forage and other forest products. We looked at a pan-tropical sample of 233 villages with forest access. Our results show that 90% of the villages experienced declining availability of forest resources over the last five years according to the informants. Timber and fuelwood together with forest foods were featured as the most strongly affected, though with marked differences across continents. In contrast, availability of at least one main forest product was perceived to increase in only 39% of the villages. Furthermore, the growing local use of forest resources is seen as the main culprit for the decline. In villages with both growing forest resource use and immigration—vividly illustrating demographic pressures—the strongest forest resources degradation was observed. Conversely, villages with little or no population growth and a decreased use of forest resources were most likely to see significant forest-resource increases. Further, villages are less likely to perceive resource declines when local communities own a significant share of forest area. Our results thus suggest that perceived resource declines have only exceptionally triggered adaptations in local resource-use and management patterns that would effectively deal with scarcity. Hence, at the margin this supports neo-Malthusian over neo-Boserupian explanations of local resource-use dynamics.
Bilinearization and special solutions to the discrete Schwarzian KdV equation

Various solutions to the discrete Schwarzian KdV equation are discussed. We first derive the bilinear difference equations of Hirota type of the discrete Schwarzian KP equation, which is decomposed into three discrete two-dimensional Toda lattice equations. We then construct two kinds of solutions in terms of the Casorati determinant. We derive the discrete Schwarzian KdV equation on an inhomogeneous lattice and its solutions by a reduction process. We finally discuss the solutions in terms of the ? functions of some Painleve systems.
Estimation of recreational potential of urban forests

The aim of this study was to evaluate two typical recreational forests in Russia and Sweden in terms of their potential for recreation. The study of Russian and Scandinavian literature was carried out as a background for the analyses of the obtained results. With these analyses the possible trends, weaknesses and strengths of the both recreational forests as well as the advantages and disadvantages of the selected method were planned to be studied. 292 forest stands covering 256.3 ha of the national park "Losiny Ostrov" (Russia) and 101 forest stands covering 198.5 ha of the Torup forest (Sweden) were investigated by the study. The selected method examines recreational forest from its attraction and comfort for visitors and tolerance (stability) to anthropogenic influence. The outcome of the estimation is based on integral assessment of these three categories, which express the recreational potential as Class of Recreational Value (CRV). The lowest results are registered among indices of stability category. It confirmed the study hypothesis about determinative function of these indices and stability category as a whole in estimation of recreational potential of forests. In about 90% of the stands in the both surveyed areas, restrictions and limits for precise recreation utilization and sustainable development in the future were recommended due to the low stability/high sensitivity of the forests. The main differences between the results from the two areas were found with regards to the attraction and comfort categories owing to social specific and traditions in forest management of the countries. The analysis showed that the method mainly corresponds with many statements of other studies in the subject. Generally the method considered as quite objective and reliable one. Nevertheless the study found it recommendable to rewrite or modify some weak points of the method but only with respect to tradition and specific of country or forest type. For the both case areas accurate forest management has to be well balanced between recreation and other forest uses. One of the main decisions should be increase the amount of, and qualities related to mature stands. This definitely could increase first of all aesthetic values of the areas.
ACCUMULATION AND PARTITION OF Fe, Zn, Cu, Mn AND Na IN MACRO AND MICRONUTRIENT-DEFICIENT COWPEA PLANTS

Cowpea (Vigna unguiculata) is an important crop for people living in the semi-arid tropics where it is used as food, animal feed and forage. Researches related to nutritional status of plants are important, principally in crops commonly grown in nutrient-poor soils. This study aimed to analyze the growth and accumulation/distribution of some micronutrients in cowpea plants submitted to macro and micronutrient deficiency. Cowpea seeds were germinated in grit and after five days, ten uniform seedlings were transferred to complete nutrient solution for an acclimatization period. After three days, the plants were grown in nutrient solution containing all macro and micronutrients or in nutrient solution without N, Ca, K, Mg, P, S, Fe, B or aeration. In all case, omission of mineral nutrients and the aeration caused reductions in the dry mass of cowpea plants, except for B; however, the absence of Ca was the most limiting for plant growth. Interestingly, the root Fe content significantly increased in Mg-, P- and S-deficient plants. Yet, Fe-deficient plants displayed a significant increase in Cu and Mn content, regardless of plant organ. Our data clearly demonstrate that the Ca is the most important nutrient for V. unguiculata growth, followed by N and Fe. The accumulation and partition of Fe, Zn, Cu and Mn in cowpea vary differentially in root, stem and leaf as affected by nutritional deficiency.
Influence of Social Media on Group Behaviour and Academic Achievement among Senior Secondary Students in Ilorin-West, Kwara State

This study was designed to find out the influence of social media usage on group behaviour and academic performance among senior secondary school students in Ilorin-West Local Government, Kwara State. The study used ex-post factor design. Purposive and simple random samplings were used to select the sample. Four senior secondary schools with a total population of 1,660 and a sample size of 310 students were drawn and used for the study. Two questionnaires were used for the study: Social Media, and Group Behaviour Questionnaire [SGBQ] and English Language and Mathematics Test [EMT]. Three research hypotheses were raised and tested. Pearson r, and ANOVA tools were used for the statistical analysis. The result shows positive correlation exists between social media usage and group behaviour. The finding shows there is negative correlation between social media usage and academic performance. The result also shows significant age difference among students. Recommendations were that: Students should be conscious of the time they spend on social media sites in order to have more time for their classroom activities and homework. Teachers should encourage the students to expend some meaningful hours on social media sites so as to make friends that would help increase their self-image. The comments of these friends are better to boost and enhance group behaviour on social media. Keyword s : social media, group behaviour and academic performance.
A study on drought stress tolerance in some maize (Zea mays L.) cultivars

Bu calismada uc misir ( Zea mays L.) kultivarinin (FR13, FRB73, TTM815) kuraklik stresine toleranslarinin arastirilmasi amaciyla bazi morfolojik ve fizyolojik parametreler analiz edilmistir. Yirmi bir gunluk bitkilere, Hoagland besin cozeltisi uygulamasi sonlandirilarak 2 (hafif kuraklik stresi), 5 (orta dereceli kuraklik stresi) ve 8 (siddetli kuraklik stresi) gun olmak uzere uc farkli kuraklik rejimi uygulanmistir. FR13 ve TTM815 kultivarlarinda orta dereceli ve siddetli kuraklik stresi kok buyumesini onemli derecede inhibe ederken, govde buyumesi misir kultivarlarinda tum kuraklik uygulamalarindan etkilenmemistir. Elde ettigimiz sonuclar misir kultivarlarinda hafif ve orta dereceli kuraklik stresi kosullarinda toplam bitki boyundaki azalmanin, kok buyumesindeki inhibisyondan kaynaklandigini ancak FRB73’un daha az etkilendigini gostermistir. Tum kultivarlarda kuraklik uygulamalari taze ve kuru biyomasin artmasina neden olmus fakat FRB73’de daha belirgin bir artis meydana gelmistir. Bu sonuclar kuraklik kosullari altinda nispeten daha stabil su miktarina sahip oldugu icin FRB73’deki su iliskilerinin daha uygun sekilde regule edildigini gostermektedir. FR13 ve TTM815’de “klorofil a” miktari uygulamalar sonunda azalirken, FRB73’de kuraklik stresinden etkilenmemistir. Diger yandan FR13 ve FRB73’de “klorofil b” icerigi kuraklik uygulamalarindan daha az etkilenmistir. Kuraklik uygulamalari sonucunda tum kultivarlardaki malondialdehit birikimi onemli derecede artmis ancak FRB73’de daha az birikim belirlenmistir. Toplam fenolik madde icerigi tum kultivarlarda ozellikle orta dereceli ve siddetli kuraklik sonucunda artmistir. FR13 ve TTM815’de toplam cozunur seker miktari orta dereceli ve siddetli kuraklik uygulamalari sonucu azalirken, FRB73’de degismemistir. Elde ettigimiz sonuclara gore FRB73’un, FR13 ve TTM815 ile karsilastirildiginda, kuraklik stresi altinda kok ve govde buyumesini surdurme yetenegi, fenolik madde, taze ve kuru biyomas artisi, su, fotosentetik pigment (klorofil a ve b) ve seker miktarinin daha az etkilenmesi ve malondialdehit birikiminin daha az olmasi nedeniyle kurakliga daha toleransli bir misir kultivari oldugu soylenebilir.
An empirical model of quiet-day ionospheric electric fields at middle and low latitudes

Seasonally averaged quiet-day F region ionospheric E × B drift observations from the Millstone Hill, St. Santin, Arecibo, and Jicamarca incoherent scatter radars are used to produce a model of the middle and low-latitude electric field for solar minimum conditions. A function similar to an electrostatic potential is fitted to the data to provide model values continuous in latitude, longitude, time of day, and day of the year. This model is intended to serve as a reference standard for applications requiring global knowledge of the mean electric field or requiring information at some location removed from the observing radars. This article contains supplementary material.
Plug-in bandwidth matrices for bivariate kernel density estimation

We consider bandwidth matrix selection for bivariate kernel density estimators. The majority of work in this area has been directed towards selection of diagonal bandwidth matrices, but full bandwidth matrices can give markedly better performance for some types of target density. Our methodological contribution has been to develop a new version of the plug-in selector for full bandwidth matrices. Our approach has the advantage, in comparison to existing full bandwidth matrix plug-in techniques, that it will always produce a finite bandwidth matrix. Furthermore, it requires computation of significantly fewer pilot bandwidths. Numerical studies indicate that the performance of our bandwidth selector is best when implemented with two pilot estimation stages and applied to sphered data. In this case our methodology performs at least as well as any competing method considered, while being simpler to implement than its competitors.