Miracle-dz/UniFAR-FTUs huggingface dataset:
Changing test and data modeling requirements for screening latent defects as statistical outliers

The expanded role of test demands a significant change in mind-set of nearly every engineer involved in the screening of semiconductor products. The issues to consider range from DFT and ATE requirements, to the design and optimization of test patterns, to the physical and statistical relationships of different tests, and finally, to the economics of reducing test time and cost. The identification of outliers to isolate latent defects will likely increase the role of statistical testing in present and future technologies. An emerging opportunity is to use statistical analysis of parametric measurements at multiple test corners to improve the effectiveness and efficiency of testing and reliability defect stressing. In this article, we propose a "statistical testing" framework that combines testing, analysis, and optimization to identify latent-defect signatures. We discuss the required characteristics of statistical testing to isolate the embedded-outlier population; test conditions and test application support for the statistical-testing framework; and the data modeling for identifying the outliers.
Quantitative Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry for Rapid Resistance Detection

ABSTRACT Antibiotic resistance in Gram-negative microorganisms is an increasing health care problem. The rapid detection of such resistance is crucial for starting an early specific therapy and to enable initiation of the required hygiene measures. With continued emphasis on reducing the cost of laboratory testing, only economical/low-cost approaches have a chance of being implemented. During recent years, matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS) has been developed to be a standard method in microbiology laboratories for the rapid and cost-efficient identification of microorganisms. Extending the usage of MALDI-TOF MS in the clinical microbiology laboratory to the area of resistance testing is an attractive option. Quantitative MALDI-TOF MS using an internal standard facilitates the measurement of the quantity of peptides and small proteins within a spectrum. These quantities correlate to the number of microorganisms and therefore to the growth of a microorganism. The comparison of growth in the presence or absence of an antibiotic allows for analysis of the susceptibility behavior of a strain. Here, we describe a novel method and its application in the analysis of 108 Klebsiella sp. isolates. After 1 h of incubation at a meropenem concentration of 8 μg/ml, a sensitivity of 97.3% and a specificity of 93.5% were achieved (compared to Etest results).
Sex Difference for Urologic Malignancy Risk in Uremic Patients After Kidney Transplantation: A Population-based Study

Background High urologic malignancy incidence has been reported in end-stage renal disease (ESRD) patients, especially of female sex. This study was undertaken to evaluate whether female recipients still carry an aggravated risk of this malignancy after kidney transplantation (KT). Methods The claims data from the Bureau of National Health Insurance of Taiwan were used for analysis. All KT recipients who developed urologic malignancy from January 1, 1999, to December 31, 2007 (n = 2,245) were enrolled in this study. By means of propensity score, a database of 1:4 ratio random incident ESRD patients with matched age, sex, comorbidity rates, and dialysis to index date was used as control (non-KT group, n = 8,980). The last observation period ended on December 31, 2008. Results The cumulative urologic malignancy incidence rate was significantly higher in female recipients after KT than their female ESRD counterparts without KT (P < 0.001). This gap became more prominent approximately 2 years after transplantation. No similar trend was detected in male KT patients (P = 0.13). Incidence rate ratio of urologic malignancy was significantly higher in female recipients (incidence rate ratio, 2.13; 95% confidence interval [95% CI], 1.53–2.97) than in their male counterparts (incidence rate ratio, 1.43; 95% CI, 0.90–2.25). From multivariate Cox proportional hazard regression tests, female (hazards ratio, 2.10; 95% CI, 1.52–2.95) but not male sex (hazards ratio, 1.47; 95% CI, 0.93–2.32) was determined to be an independent factor for the development of urologic malignancy after KT. After acquiring this malignancy, KT recipients did not have any advantage in cumulative survival compared to ESRD patients without KT (P = 0.07). Conclusion Compared to males, female recipients tended to have a significantly higher urologic malignancy risk after KT.
PENGARUH MONEY ETHICS DAN RELIGIOSITY TERHADAP TAX EVASION (Studi Pada Wajib Pajak Orang Pribadi Di KPP Pratama Semarang Candisari)

This study was conducted to examine and analyze the influence of money ethics and religiosity against tax evasion. The research method used primary data is by distributing questionnaires to 120 individual taxpayer on KPP Pratama Semarang Candisari. The sampling technique used was convenience sampling. The data analysis techniques used multiple regression analysis using SPSS. The results of the study showed that money ethics influence on tax evasion, howefer religiosity has no effect. Keywords: Money Ethics, Religiosity, Tax Evasion
Is Opportunistic Investing Rewarding? – A Study of United Kingdom Unlisted Funds

This study primarily investigates the impact of extreme financial leverage on UK unlisted property fund performance over a 11 year period, 2004 to 2014; accordingly the research problem is addressed applying a panel auto regression to an extended sample provided by the IPD Property Fund Vision Handbook covering funds information over a complete property cycle from 2004 to 2014. The results provide strong evidence in support of the traditional theory of capital structure asserting that financial leverage is a significant determinant of firm performance. A significant positive relationship is found between Leverage and performance of core and value added funds over the cycle but interestingly a significant negative association is seen for opportunistic funds as they under performed through the cycle. Consequently, it is concluded that fund value may be enhanced by debt finance but must be kept at minimal levels, as an optimal debt finance level seems to exist considering the behavior of Opportunistic funds over the investigated period. Key to the deduction is that irrespective of investment style (gearing intensity) through the cycle, performance persistence seems to sum the success or failure of UK unlisted property funds as lagged return showed a significant positive relationship in all regression results. Therefore the question of whether an unlisted fund persists in performance becomes even more decisive in determining how investors should select funds and develop investment strategies.
Fatty fish consumption lowers the risk of endometrial cancer: a nationwide case-control study in Sweden.

The consumption of fatty fish, which contains large amounts of omega-3 fatty acids, may lower the risk of hormone-responsive cancers. Our aim was to study the association of fish consumption and endometrial cancer risk in Sweden, a country with a wide range of high fatty fish consumption. Using data from a large, nationwide case-control study (709 cases and 2888 controls), we analyzed consumption of both fatty (e.g., salmon and herring) and lean (e.g., cod and flounder) fish in relation to endometrial cancer risk, adjusting estimates for a wide range of potentially confounding variables. Odds ratios (ORs) and 95% confidence intervals (CIs) were computed from unconditional logistic regression models fit by maximum likelihood methods. Consumption of fatty fish was inversely associated with endometrial cancer risk. The multivariate OR for women in the highest quartile level (median, 2.0 servings per week), compared to women with in the lowest (median, 0.2 servings per week), was 0.6 (95% CI, 0.5-0.8; P for trend, 0.0002). The corresponding OR for women in the highest quartile level of lean fish (median, 2.5 servings per week), compared to women in the lowest (median, 0.6 servings per week), was 1.0 (95% CI, 0.8-1.3; P-value for trend, 0.72). Total fish consumption was inversely associated with risk, although weakly. Our results suggest that the consumption of fatty fish, but not other types of fish, may decrease the risk of endometrial cancer.
Investigation of the RTN Distribution of Nanoscale MOS Devices From Subthreshold to On-State

This letter presents a numerical investigation of the statistical distribution of the random telegraph noise (RTN) amplitude in nanoscale MOS devices, focusing on the change of its main features when moving from the subthreshold to the on-state conduction regime. Results show that while the distribution can be well approximated by an exponential behavior in subthreshold, large deviations from this behavior appear when moving toward the on-state regime, despite a low probability exponential tail at high RTN amplitudes being preserved. The average value of the distribution is shown to keep an inverse proportionality to channel area, while the slope of the high-amplitude exponential tail changes its dependence on device width, length, and doping when moving from subthreshold to on-state.
Stressed and Helping: The Relations Among Acculturative Stress, Gender, and Prosocial Tendencies in Mexican Americans

ABSTRACT Available evidence suggests that stress is not necessarily linked to negative outcomes and, in fact, may lead to increases in sympathy and helping. In this study, we examined whether acculturative stress was associated with prosocial tendencies in a sample of 148 Mexican American college students (M age = 23.05 years; 99 women). Participants completed measures of acculturative stress, sympathy, and prosocial tendencies. The relations between acculturative stress and prosocial tendencies were generally positive but varied by the type of helping and gender. Higher levels of acculturative stress were linked to greater emotional, dire, compliant, and anonymous prosocial tendencies, as well as with fewer costly (altruistic) prosocial tendencies. Sympathy mediated the relations between acculturative stress and prosocial tendencies for men only.
Profiling genomic copy number changes in retinoblastoma beyond loss of RB1

Loss of both RB1 alleles is rate limiting for development of retinoblastoma (RB), but genomic copy number gain or loss may impact oncogene(s) and tumor suppressor genes, facilitating tumor progression. We used quantitative multiplex polymerase chain reaction to profile “hot spot” genomic copy number changes for gain at 1q32.1, 6p22, and MYCN, and loss at 16q22 in 87 primary RB and 7 cell lines. Loss at 16q22 (48%) negatively associated with MYCN gain (18%) (Fisher's exact P = 0.031), gain at 1q32.1 (62%) positively associated with 6p “hot spot” gain (43%) (P = 0.033), and there was a trend for positive association between 1q and MYCN gain (P = 0.095). Cell lines had a higher frequency of MYCN amplification than primary tumors (29% versus 3%; P= 0.043). Novel high‐level amplification of 1q32.1 in one primary tumor, confirmed by fluorescence in situ hybridization, strongly supports the presence of oncogene(s) in this region, possibly the mitotic kinesin, KIF14. Gene‐specific quantitative multiplex polymerase chain reaction of candidate oncogenes at 1q32.1 (KIF14), 6p22 (E2F3 and DEK), and tumor suppressor genes at 16q22 (CDH11) and 17q21 (NGFR) showed the most common gene gains in RB to be KIF14 in cell lines (80%) and E2F3 in primary tumors (70%). The patterns of gain/loss were qualitatively different in 25 RB compared with 12 primary hepatocellular carcinoma and 12 breast cancer cell lines. Gene specific analysis of one bone marrow metastasis of RB, prechemotherapy and postchemotherapy, showed the typical genomic changes of RB pretreatment, which normalized after chemotherapy. © 2006 Wiley‐Liss, Inc.
Association Between Aerobic Exercise and Rosiglitazone Avoided the NAFLD and Liver Inflammation Exacerbated in PPAR‐α Knockout Mice

Nonalcoholic fatty liver disease (NAFLD) is one of the main liver diseases today, and may progress to steatohepatitis, cirrhosis, and hepatocellular carcinoma. Some studies have shown the beneficial effects of aerobic exercise on reversing NAFLD. To verify whether chronic aerobic exercise improves the insulin resistance, liver inflammation, and steatohepatitis caused by a high fat diet (HF) and whether PPARα is involved in these actions. C57BL6 wild type (WT) and PPAR‐α knockout (KO) mice were fed with a standard diet (SD) or HF during 12 weeks; the HF mice were trained on a treadmill during the last 8 weeks. Serum glucose and insulin tolerances, serum levels of aspartate aminotransferase, hepatic content of triacylglycerol, cytokines, gene expression, and protein expression were evaluated in all animals. Chronic exposure to HF diet increased triacylglycerol accumulation in the liver, leading to NAFLD, increased aminotransferase in the serum, increased peripheral insulin resistance, and higher adiposity index. Exercise reduced all these parameters in both animal genotypes. The liver lipid accumulation was not associated with inflammation; trained KO mice, however, presented a huge inflammatory response that was probably caused by a decrease in PPAR‐γ expression. We conclude that exercise improved the damage caused by a HF independently of PPARα, apparently by a peripheral fatty acid oxidation in the skeletal muscle. We also found that the absence of PPARα together with exercise leads to a decrease in PPAR‐γ and a huge inflammatory response. J. Cell. Physiol. 232: 1008–1019, 2017. © 2016 Wiley Periodicals, Inc.
Metabolic defense of the body weight set-point.

The energy needs of an organism are a function of the tissue mass it maintains. Interspecific comparisons indicate that energy needs are a power function of body weight (12). Much of the work described here represents an effort to ascertain whether the function relating intraspecific energy expenditure to maintained body weight takes a similar form. The evidence to date from various rat preparations suggests that although some differences may exist, the form of the function for rats is not likely to differ substantially from the interspecific function derived by Kleiber (12). What has also emerged from this work, however is evidence that both the inter- and intraspecific functions accurately predict energy needs only when the organism is at the particular body weight it normally maintains and defends. This is because a rise in weight from the normal level causes energy needs to increase at a faster rate than the relationship would predict, whereas declines in weight from this level produce greater than predicted decreases in energy expenditure. We thus propose that an animal's body weight set-point be taken as the weight at which its daily energy needs can be accurately predicted from its metabolic body size. It is only at this one body weight that the animal is normometabolic. It can then be asked whether organisms maintaining abnormally high or low body weights are suffering from regulatory dysfunctions or regulating normally but at elevated or depressed set-points. We have seen that obese Zucker rats display the same adaptive metabolic adjustments to weight loss as normal weight rats. Since the exact form of the intraspecific body weight-metabolic needs relationship has not yet been determined, we must withhold judgment as to whether Zucker fatty rats are normometabolic at their elevated body weights. Since they display an effective metabolic defense of their obesity, however, an elevated set-point, rather than regulatory failure, seems to be the more probable cause of the Zucker fatty's condition. More compelling evidence of regulation at an altered body weight set-point is provided by the LH-lesioned rat. This preparation is normometabolic at the reduced body weight it maintains, and it becomes hypermetabolic when its weight is elevated to the level of nonlesioned littermates. The obesity of the VMH-lesioned rat, on the other hand, may well stem from primary regulatory impairments. (ABSTRACT TRUNCATED AT 400 WORDS)
Spinning disk confocal microscopy of live, intraerythrocytic malarial parasites. 1. Quantification of hemozoin development for drug sensitive versus resistant malaria.

We have customized a Nipkow spinning disk confocal microscope (SDCM) to acquire three-dimensional (3D) versus time data for live, intraerythrocytic malarial parasites. Since live parasites wiggle within red blood cells, conventional laser scanning confocal microscopy produces blurred 3D images after reconstruction of z stack data. In contrast, since SDCM data sets at high x, y, and z resolution can be acquired in hundreds of milliseconds, key aspects of live parasite cellular biochemistry can be much better resolved on physiologically meaningful times scales. In this paper, we present the first 3D DIC transmittance "z stack" images of live malarial parasites and use those to quantify hemozoin (Hz) produced within the living parasite digestive vacuole, under physiologic conditions. Using live synchronized cultures and voxel analysis of sharpened DIC z stacks, we present the first quantitative in vivo analysis of the rate of Hz growth for chloroquine sensitive (CQS) versus resistant (CQR) malarial parasites. We present data for laboratory strains, as well as pfcrt transfectants expressing a CQR conferring mutant pfcrt gene. We also analyze the rate of Hz growth in the presence and absence of physiologically relevant doses of chloroquine (CQ) and verapamil (VPL) and thereby present the first in vivo quantification of key predictions from the well-known Fitch hypothesis for CQ pharmacology. In the following paper [Gligorijevic, B. , et al. (2006) Biochemistry 45, pp 12411-12423], we acquire fluorescent images of live parasite DV via SDCM and use those to quantify DV volume for CQS versus CQR parasites.
The nasomaxillary complex and the cranial base in artificial cranial deformation: relationships from a geometric morphometric study.

INTRODUCTION It is widely accepted that there is a relationship between the cranial base and the development of the nasomaxillary complex (NMC). The objective of the present study was to investigate the morphological relationship between these two anatomical units in skulls that have intentionally been subjected to one of two types of artificial deformity of the cranial vault [artificially deformed skulls (ADS)]. MATERIAL AND METHODS A geometric morphometry study was performed on lateral cephalometric X-rays of three groups of crania: 32 with anteroposterior (AP) deformity, 17 with circumferential (C) deformity, and 39 with no apparent deformity. RESULTS The cranial base of the ADS showed marked deformity that produced a restriction of AP growth of the NMC, alterations of the roof of the orbit as a consequence of the rotation of anterior cranial fossa, and nasal protrusion. Pronounced morphological differences were found between the three groups: increased vertical development of the maxilla occurred in both ADS groups due to growth of the alveolar process, and rotation of the maxilla and displacement of the orbital rim was observed in the C group. This confirms that the posterior facial plane is regarded as an axial structure that serves as an interface between the middle cranial base and the NMC (Enlow, D.H. and Hans, M.G. (1996) Essential of Facial Growth. WB Saunders Co., Philadelphia, PA). LIMITATIONS It is important to take into account that these results have been obtained from an archaeological sample, with all the limitations that this implies such as being a small sample and with no absolute certainty regarding the use of the same type of deforming device within each group. Furthermore, this is a lateral two-dimensional study in which transverse development has not been analysed. CONCLUSIONS Artificial modification of the shape of the vault has repercussions on the NMC that support the theory of an all-inclusive integration of the different cranial units in normal as well as in restricted development.
Targeted or Universal Coverage? Assessing Heterogeneity in the Effects of Universal Child Care

We provide evidence on the distributional effects of Quebec’s universal child care policy. Our analysis uncovers substantial policy relevant heterogeneity in the estimated effect of access to subsidized child care across two developmental score distributions for children from two-parent families. Whereas past research reported findings of negative effects on mothers and children from these families, igniting controversy, our estimates reveal a more nuanced image that formal child care can indeed boost developmental outcomes for children from some households: particularly disadvantaged single-parent households. We present suggestive evidence that the heterogeneity in policy effects is consistent with differences in home learning environments.
Adverse events of statin–fenofibric acid versus statin monotherapy: a meta-analysis of randomized controlled trials

Abstract Background: Patients with mixed dyslipidemia can benefit from the combination of fenofibric acid (FA) with statins, but concerns about adverse events make physicians reluctant to prescribe the combination therapy. Objective: In the present study, we performed a meta-analysis of randomized controlled trials (RCTs) to assess the efficacy and adverse events in patients taking statins and FA. Methods: Medline, Embase and the Cochrane Library were searched to identify studies that reported adverse events. Finally, five trials covering 2704 patients were selected in this study. Results: There were significant decreases in TG and increases in HDL-C in patients receiving combination therapy compared with statin monotherapy. The incidence of hepatic toxicity (OR, 3.57; 95% CI, 1.17–10.83; P < 0.05) and increased creatinine (OR, 3.22; 95% CI, 1.28–8.11; P < 0.05) was significantly higher in the FA + low-dose statin group than in the corresponding statin monotherapy. The incidence of CK elevations and muscle-associated AEs was not statistically different between the two groups. The adverse events in the FA + moderate-dose statin group were almost identical to those in the FA + low-dose statin group. Conclusions: In conclusion, combination therapy could improve the blood lipid profile. Addition of FA to statins therapy is more frequently associated with hepatic and renal toxicity than muscle-associated AEs. Therefore patients taking the combination of FA with statins should have liver enzyme and renal function monitored. However, we still need large-scale and long follow-up period RCTs to definitively confirm the adverse events of FA–statin therapy.
Anatomical versus non‐anatomical resection for solitary hepatocellular carcinoma without macroscopic vascular invasion: A propensity score matching analysis

The superiority of anatomical resection (AR) in patients with hepatocellular carcinoma compared with non‐anatomical resection (NAR) remains controversial. We aimed to investigate the prognostic outcomes of AR and NAR for solitary hepatocellular carcinoma (HCC) patients without macroscopic vascular invasion, using a propensity score matching (PSM) analysis.