Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinical and Immunohistochemical Features of Sebaceous Carcinoma: Focusing on the p53 Tumor Suppressor

Purpose: Considerable focus has recently revealed the importance of p53 in sebaceous carcinoma (SC). This study investigates the utility of p53 as an immunohistochemistry (IHC) marker for differentiating benign and malignant sebaceous tissues and reports the clinical characteristics of patients diagnosed with SC at Mount Sinai Hospital (MSH). Methods: A retrospective chart analysis of 102 patients with SC was performed in addition to a histopathological examination of benign and malignant sebaceous tissues. Immunohistochemistry was performed in 30 cases of SC, 4 cases of sebaceous hyperplasia, 4 cases of sebaceous epitheliomas, and 3 cases of sebaceous adenoma. A separate outpatient cohort was used to compare the clinical and histologic features of eyelid lesions. This included 31 available cases with histologic descriptions of SC. The clinical features of 20 SC cases, 25 BCC cases, and 21 chalazia cases were available and compared from this outpatient cohort. Data collected included age, gender, lesion anatomical location, histopathologic descriptions, and percentage of p53 positive sebocytes. Results: Of the 102 SC cases at MSH, the mean age was 69 years, males composed 58%, and 59% were periorbital or orbital. Positive p53 staining without atypia was reproducibly observed at cell membranes in all cases of sebaceous hyperplasia. Using a standardized p53 grading system used at MSH, the average p53 staining grade for SC and epithelioma was calculated to be 2.3 ± 0.7 and 1 ± 0.7, respectively (p=0.002). An outpatient cohort revealed that 65% of SC was found on the lower eyelid and 84% of BCC was on the upper eyelid. The most common histologic features seen in SC were nuclear atypia (61%) and cytoplasmic vacuoles (55%). Conclusions: This study provides the first comprehensive staining profile of p53 in benign and malignant sebaceous tissues. We also report for the first time that membrane p53 staining was helpful and appeared to be highly specific for identifying sebaceous hyperplasia. p53 staining was also helpful for identifying SC and intraepithelial spreading tumor cells. The clinical and histologic characteristics of specific eyelid lesions in an outpatient setting are also shared. Lastly, this work incorporates the latest research to synthesize IHC recommendations for improving SC detection.
Arti cial intelligence methods to support people management in organisations

Las organizaciones han pasado del trabajo focalizado en individuos a estructuras de trabajo basadas en equipos. Una nueva generacion de soluciones para las organizaciones debe proporcionar la gestion de equipos, fomentando la eficacia del equipo mediante la automatizacion. En esta tesis abordamos varios problemas centrales para la gestion de equipos en organizaciones. En particular, proponemos una solucion que aborda los problemas relacionados con la composicion del equipo, asi como los problemas de evaluacion de los empleados y la evaluacion del rendimiento de las tareas. En primer lugar, revisamos la literatura sobre la composicion y formacion de equipos, tanto desde la perspectiva de la psicologia organizacional como de las ciencias de la computacion. Exploramos la conexion entre los atributos de los individuos y el rendimiento del equipo, asi como las oportunidades de intercambio de ideas entre estos dos campos. En segundo lugar, revisamos las herramientas mas destacadas para medir los atributos de los individuos, ya que estas medidas son necesarias para los procesos de composicion de equipos. En particular, describimos los enfoques dominantes en Psicologia Organizacional, Psicologia Industrial y Recursos Humanos, resumiendo los principales hallazgos para medir la personalidad y las competencias de los individuos. En tercer lugar, utilizamos nuestros observaciones para proponer un modelo que predice el rendimiento de un equipo dada una tarea y en funcion de los atributos de los individuos (competencias, personalidad y genero). Definimos el Synergistic Team Composition Problem (STCP) como el problema de encontrar una particion de equipos restringida por tamano para que cada equipo, y toda la particion de empleados en equipos, sea equilibrada en terminos de competencias individuales, personalidad y genero. Proponemos dos algoritmos diferentes para resolver este problema: un algoritmo optimo llamado STCPSolver que es efectivo para pequenas instancias del problema, y ​​un algoritmo aproximado llamado SynTeam, que proporciona soluciones de alta calidad, pero no necesariamente optimas. A continuacion, presentamos los resultados empiricos que obtuvimos al analizar el rendimiento de nuestros algoritmos en un ambito educativo. Nuestros resultados muestran los beneficios de una composicion de equipos mas informada utilizando las competencias, las personalidades y el genero de las personas. En cuarto lugar, disenamos un algoritmo llamado Collaborative Judgment (CJ) para evaluar de un modo justo los resultados de los individuos y el rendimiento de los equipos que han realizado las tareas. En particular, el objetivo del algoritmo es disminuir la importancia de los sesgos en el proceso de evaluacion a traves de la evaluacion entre los propios evaluadores. Nuestros resultados empiricos muestran los beneficios de un metodo de agregacion de evaluaciones mas informado.
Time-Fractional Diffusion with Mass Absorption in a Half-Line Domain due to Boundary Value of Concentration Varying Harmonically in Time

The time-fractional diffusion equation with mass absorption is studied in a half-line domain under the Dirichlet boundary condition varying harmonically in time. The Caputo derivative is employed. The solution is obtained using the Laplace transform with respect to time and the sin-Fourier transform with respect to the spatial coordinate. The results of numerical calculations are illustrated graphically.
Conflicts Management Model in School: A Mixed Design Study

The object of this study is to evaluate the reasons for conflicts occurring in school according to perceptions and views of teachers and resolution strategies used for conflicts and to build a model based on the results obtained. In the research, explanatory design including quantitative and qualitative methods has been used. The quantitative part of the research has been designed as the relational quantitative model. Data have been collected from 216 teachers working in the province of Sivas through the Scale of Reasons for Conflicts and the Scale of Resolution Strategies. The qualitative part of the research has been conducted in conformity with the case study design. Data has been gathered from 20 teachers working in the province of Sivas through open-ended questions. According to the research findings, the reasons for conflicts occurring in school has been diversified based on the way of doing things, individual differences and school management. The strategies for conflict solution used by the teachers vary according to school shareholders in which they experience conflict. Furthermore, findings have been obtained regarding that there is not any common management policy in the school. In this context, “Management Model for Conflict in School” for building conflict management culture in the school has been made.
Pharmacokinetic comparison of a fixed-dose combination versus concomitant administration of fimasartan, amlodipine, and rosuvastatin using partial replicated design in healthy adult subjects

Objective The aim of this study was to compare the pharmacokinetics (PK) and safety profiles of a fixed-dose combination (FDC) formulation of fimasartan, amlodipine, and rosuvastatin with the co-administration of the two products by using a replicated crossover study design in healthy male subjects. Results This was an open-label, randomized, three-sequence, three-period replicated crossover study in healthy male subjects. The replicated crossover design was done because of high coefficient of variation of PK parameter for fimasartan, that is, >30%. With a 14 days washout period, an FDC tablet containing 60 mg fimasartan, 10 mg amlodipine, and 20 mg rosuvastatin was administered only once, and separate formulations of fimasartan/amlodipine 60 mg/10 mg FDC tablet and 20 mg rosuvastatin tablet administered twice. Blood samples were collected up to 72 hours following drug administration. The plasma concentrations of fimasartan, amlodipine, and rosuvastatin were measured by liquid chromatography tandem mass spectrometry. Safety was assessed by evaluating vital signs, clinical laboratory parameters, physical examinations, and medical interviews. Results The geometric mean ratios and 90% confidence intervals (CIs) for the maximum plasma concentration (Cmax) and area under the curve from time zero to the last measurable sampling time (AUCt) were 1.0776 (0.9201–1.2622) and 0.9978 (0.9538–1.0439) for fimasartan, 1.0038 (0.9782–1.0301) and 1.0055 (0.9828–1.0288) for amlodipine, and 1.0006 (0.9290–1.0776) and 0.9986 (0.9532–1.0461) for rosuvastatin, respectively. A total of 22 adverse events (AEs) were reported by 60 subjects; there were no significant differences in the incidence of AEs between the two groups. Conclusion The 90% CI of the Cmax of fimasartan was within the widened acceptance limit, ln(0.6984)–ln(1.4319). The 90% CIs of the other PK parameters for drugs were between ln(0.8) and ln(1.25). These results suggest that the FDC formulation is pharmacokinetically bioequivalent and has a similar safety profile, to the co-administration of its three constituent drugs.
Epidemiology of mental disorders among adolescents in the city of Bandar Abbas , Iran , in 2012

Mental disorders are a very common health problem among adolescents. The purpose of this study was to determine the prevalence of mental disorders in high school adolescents in the city of Bandar Abbas in the 2012 academic year. In this study, the cluster sampling method was used to select 800 subjects from the student population of the high school, and a survey of their mental health was conducted by using the SCL-90-R questionnaire. The survey results were used to identify students who were suspected of having a mental disorder, and those students were evaluated using an interview method based on DSM-IV. The results showed that 16.7% of the 800 students included in the study had some mental disorder. Anxiety and mood disorders were the most prevalent mental disorders observed, with prevalence percentages of 85% and 39%, respectively. Among the demographic variables, 22% of the girls and 11% of the boys had some disorder. There were significant relationships between the mental disorders of the adolescents and a number of variables, including a family history of mental disorders, the occurrence of divorce in their families, drug addiction, and alcohol consumption. Mental disorders in the city of Bandar Abbas were more prevalent among adolescent girls than boys, and specific anxiety disorders, such as anxiety, obsessive-compulsive disorder, and depression, occurred more frequently than other mental disorders. Mental disorders were more prevalent among students from families in which there was a family history of mental disorders, divorce, drug addiction, and alcohol consumption. [Azita amirfakhraei, Afsaneh alinaghizadeh. Epidemiology of mental disorders among adolescents in the city of Bandar Abbas, Iran, in 2012. Life Sci J 2012;9(3):976-980] (ISSN:1097-8135). http://www.lifesciencesite. com. 139
A volcanic trigger for the Late Ordovician mass extinction? Mercury data from south China and Laurentia

The Late Ordovician mass extinction (LOME), one of the five largest Phanerozoic biodiversity depletions, occurred in two pulses associated with the expansion and contraction of ice sheets on Gondwana during the Hirnantian Age. It is widely recognized that environmental disruptions associated with changing glacial conditions contributed to the extinctions, but neither the kill mechanisms nor the causes of glacial expansion are well understood. Here we report anomalously high Hg concentrations in marine strata from south China and Laurentia deposited immediately before, during, and after the Hirnantian glacial maximum that we interpret to reflect the emplacement of a large igneous province (LIP). An initial Hg enrichment occurs in the late Katian Age, while a second enrichment occurs immediately below the Katian-Hirnantian boundary, which marks the first pulse of extinction. Further Hg enrichment occurs in strata deposited during glacioeustatic sea-level fall and the glacial maximum. We propose that these Hg enrichments are products of multiple phases of LIP volcanism. While elevated Hg concentrations have been linked to LIP emplacement coincident with other Phanerozoic mass extinctions, the climate response during the LOME may have been unique owing to different climatic boundary conditions, including preexisting ice sheets. Our observations support a volcanic trigger for the LOME and further point to LIP volcanism as a primary driver of environmental changes that caused mass extinctions.
Stakeholders' Requirements Assessment for Biofuel Production

Biofuel is one of the alternatives transportation fuel to substitute petroleum in the United States. Fast pyrolysis, as one of the most promising thermochemical based advanced biofuel production techniques, has been brought to the forefront of biofuel industry. With limited information about the manufacturing of fast pyrolysis units, a thorough understanding of stakeholders' requirements is timely and necessary. This study develops a comprehensive analysis of stakeholders' requirements. Subject matter experts were interviewed to rank, review, and evaluate a set of requirements for a variety of fast pyrolysis unit sizes. The requirements with the evaluations were then used to determine the most effective unit size. The analysis showed that the smallest unit size (process an average of 50 tons biomass per day) is the best alternative based on 50% of the high-prioritized requirements. However, 37.5% of the highprioritized requirements recommended the unit which process at least 2000 tons per day as the best alternative.
Higher prevalence of anemia with diabetes mellitus in moderate kidney insufficiency: The Kidney Early Evaluation Program.

BACKGROUND The Kidney Early Evaluation Program (KEEP 2.0) cross-sectional, community-based study, targeted individuals at increased risk for kidney disease and measured blood glucose, creatinine, and hemoglobin. METHODS KEEP 2.0 screening data were used to determine the prevalence of anemia by level of kidney function and diabetes status. Estimated glomerular filtration rate (EGFR) was calculated using serum creatinine values, and categorized as > or =90, 60-89, 30-59 and <30 mL/min/1.73 m(2). Anemia was defined as hemoglobin <12 g/dL in men and in women aged >50 years, and <11 g/dL in women < or =50 years. Diabetes was defined as participant-reported diagnosis, fasting glucose >125 mg/dL, or nonfasting glucose >200 mg/dL. RESULTS Data were available on 5380 participants screened from August 2000 through December 2001. Diabetes was present in 26.9% of participants, and anemia in 7.7%; 15.9% of participants had at least moderately reduced kidney function (EGFR <60 mL/min/1.73 m(2)). In participants with diabetes, anemia prevalence at the 4 levels of descending EGFR were 8.7%, 7.5%, 22.2%, and 52.4%, compared with 6.9%, 5.0%, 7.9%, and 50.0% in persons without diabetes. In a multivariable model, participants of non-white race/ethnicity, those with diabetes and those with EGFR <30 or 30-59 mL/min/1.73 m(2) had significantly increased odds of anemia. In addition, a significant sex-diabetes interaction was identified; odds of anemia were 4-fold greater in men than women with diabetes relative to sex-matched participants without diabetes. CONCLUSION Diabetes was independently correlated with anemia, more so in men than women, and may be linked to premature expression of anemia in persons with moderate reductions in kidney function.
Rab4 Is an Essential Regulator of Lysosomal Trafficking in Trypanosomes*

Rapid endocytosis and recycling of surface proteins are important processes common to most nucleated eukaryotic cells. The best characterized membrane recycling routes are mediated by the small GTPases Rab4 and Rab11, but the precise roles that these pathways play have not been fully elucidated. The protozoan Trypanosoma brucei has a highly developed endocytic system that is similar to that found in metazoans, albeit with an accelerated rate of membrane turnover. We have used this organism to investigate the function of the trypanosome orthologue of Rab4 (TbRAB4) by a combination of RNA interference, microscopy, and quantitative trafficking assays. RNA interference-mediated suppression of TbRAB4 expression inhibited the growth of trypanosomes without affecting receptor-mediated endocytosis or ligand recycling. Ultrastructural analysis indicated a major defect in membrane transport events. The accumulation of fluorescent dextran, a fluid-phase marker, was blocked in cells lacking TbRAB4 protein. Since most fluid-phase markers are transported to the lysosome in T. brucei, the effects of TbRAB4 RNA interference on lysosomal function were investigated. By immunofluorescence, the major lysosomal protein p67 became progressively dispersed in cells lacking the TbRAB4 protein. Pulse-chase analysis demonstrated that initial proteolytic cleavage and glycan processing of p67 were unaffected but that cells failed to accumulate the later p67 proteolyzed products associated with the lysosome. To confirm the role of TbRAB4 in lysosomal trafficking, a constitutively active mutant, TbRAB4QL, was expressed. TbRAB4QL was closely associated with an enlarged multivesicular body that contained p67. In addition, cells expressing TbRAB4QL showed increased fluid-phase uptake when compared with the parental line. Taken together, these data suggest that TbRAB4 is involved in regulation of fluid-phase traffic to the lysosome in T. brucei but not in receptor-mediated endocytosis or recycling. These data have implications for the role of Rab4 in other cell systems.
CD36 initiates the secretory phenotype during the establishment of cellular senescence

Cellular senescence is a unique cell fate characterized by stable proliferative arrest and the extensive production and secretion of various inflammatory proteins, a phenomenon known as the senescence‐associated secretory phenotype (SASP). The molecular mechanisms responsible for generating a SASP in response to senescent stimuli remain largely obscure. Here, using unbiased gene expression profiling, we discover that the scavenger receptor CD36 is rapidly upregulated in multiple cell types in response to replicative, oncogenic, and chemical senescent stimuli. Moreover, ectopic CD36 expression in dividing mammalian cells is sufficient to initiate the production of a large subset of the known SASP components via activation of canonical Src–p38–NF‐κB signaling, resulting in the onset of a full senescent state. The secretome is further shown to be ligand‐dependent, as amyloid‐beta (Aβ) is sufficient to drive CD36‐dependent NF‐κB and SASP activation. Finally, loss‐of‐function experiments revealed a strict requirement for CD36 in secretory molecule production during conventional senescence reprogramming. Taken together, these results uncover the Aβ–CD36–NF‐κB signaling axis as an important regulator of the senescent cell fate via induction of the SASP.
Theoretical model of development of information competence among students enrolled in elective courses

The current study focuses on the research topic of creating a theoretical model of development of information competence among students enrolled in elective courses. In order to examine specific features of the theoretical model of development of information competence among students enrolled in elective courses, we performed an analysis of formation of the concept “information competence of students”. We investigated and provided theoretical substantiation for meaningful characteristics of information competence of students. We developed and validated the theoretical model of development of information competence among students enrolled in elective courses, including criteria, parameters and efficiency levels of this process. We recommend to implement the theoretical model of development of information competence among students enrolled in elective courses for development of higher educational programs. OPEN ACCESS
New Perspectives on the â€˜Net Errors & Omissionsâ€™ in Balance of Payment Accounts: An Empirical Study - Australia

This study aims to identify and examine the potential economic factors that determining the â€˜net errors & omissionsâ€™ (EO) in balance of payment accounts. Two structural specifications are derived from the balance of payments (BoP) constraint, and open economy macro equilibrium (income-expenditure approach), respectively. There are some positive findings. The empirical results obtained from the Australian data show real GDP, foreign income, foreign interest rate, domestic interest rate, and exchange rate have either directly or indirectly caused EO over the sample period 1960-2010. Also, a reverse direction is obtained from EO to domestic interest rate. This study is considered as an important reference for further research.
Intention to Stay in Nursing Profession and Its Predictors among Nurses Working in Jimma Zone Public Hospitals, South West Ethiopia

Background: Hospitals are facing difficulties to providing a consistent level of quality nursing care in a fastchanging health environment due to the shortage of experienced nurses which is a critical global issue. A number of nurses were quitting their profession to continue career in another profession in clinical and non-clinical fields. Factors that cause these problems were not investigated in Ethiopia yet. This study aims to assess the level of intention to stay in the nursing profession and its predictors among nurses working in Jimma Zone public Hospitals.Methods: Institution based cross-sectional study was conducted on 317 nurses. Structured self-administered questionnaires were used to collect data. Data were entered and cleaned by using Epi-data version 3.1 then exported to IBM SPSS version 20 for analysis. Independent sample t-test, one-way ANOVA, and linear regression were done to see mean difference and association of variables. P-value of less than 0.05 was taken as statistically significant.Result: The overall level of intention to stay is 57.75% of which 133 (42%) of them had low, 95 (30%) of them have moderate and the rest 89 (28.1%) have a high level of intention to stay in the profession. Organizational and professional commitment, working hospital, job satisfaction, organizational factor, and job-related stress were identified as predictors of intention of nurses to stay in their profession.Conclusion: The overall level of intention to stay is low. Only less than one-third of nurses have high intention to stay in their profession in this study. Improving this level of intention needs collaborative intervention in related factors which are a big homework for managers on health sectors of Jimma zone public Hospitals.
Towards Building A Profession: Characteristics Of Contemporary Educators In American Jewish Schools

Ever since Jewish education confronted modernity on the shores of North America early in the twentieth century, reformers have dreamed of a "profession" of Jewish education. One advocate of change was Emanuel Gamoran, a student of John Dewey at Teachers College, Columbia University, and the first director of education for the Union of American Hebrew Congregations, the Reform Movement in the U.S. In his first year on the job he wrote (1924, p.5):