Miracle-dz/UniFAR-FTUs huggingface dataset:
Cаlіx[4]аrene С-956 is effective inhibitor of Н(+)-Сa(2+)-exchanger in smooth muscle mitochondria

it was shown that calix[4]arene c-956 exhibited a pronounced concentration-dependent (10-100 μm) inhibitory effect on the h+-ca2+-exchanger of the inner mitochondrial membrane of rat uterine myocytes (Ki 35.1 ± 7.9 μm). the inhibitory effect of calix[4]arene c-956 was accompanied by a decrease in the initial rate (V0 ) and an increase in the magnitude of the characteristic time (τ1/2) of the ΔрН-induced Са 2+ release. At the same time, it did not affect the potential-dependent accumulation of ca2+ in mitochondria. thus, the action of calix[4]arene c-956 might be directed on increasing the concentration of ca ions in the mitochondrial matrix. the calculation of basic kinetic parameters of the ca2+ transport from isolated organelles (in the case of its non-zero stationary level), based on changes in fluorescence of ca2+-sensitive dye Fluo-4 Am in mitochondria was performed. the proposed approach can be used for the kinetic analysis of the exponential decrease of the fluorescence response of any probes under the same experimental conditions.
RADIAL DISTRIBUTION OF STARS, GAS, AND DUST IN SINGS GALAXIES. II. DERIVED DUST PROPERTIES

We present a detailed analysis of the radial distribution of dust properties in the SINGS sample, performed on a set of ultraviolet (UV), infrared (IR), and H i surface brightness profiles, combined with published molecular gas profiles and metallicity gradients. The internal extinction, derived from the total-IR (TIR)-to-far-UV (FUV) luminosity ratio, decreases with radius, and is larger in Sb–Sbc galaxies. The TIR-to-FUV ratio correlates with the UV spectral slope β, following a sequence shifted to redder UV colors with respect to that of starbursts. The star formation history (SFH) is identified as the main driver of this departure. Both LTIR/LFUV and β correlate well with metallicity, especially in moderately face-on galaxies. The relation shifts to redder colors with increased scatter in more edge-on objects. By applying physical dust models to our radial spectral energy distributions, we have derived radial profiles of the total dust mass surface density, the fraction of the total dust mass contributed by polycyclic aromatic hydrocarbons (PAHs), and the intensity of the radiation field heating the grains. The dust profiles are exponential, their radial scale length being constant from Sb to Sd galaxies (only ∼10% larger than the stellar scale length). Many S0/a–Sab galaxies have central depressions in their dust radial distributions. The PAH abundance increases with metallicity for 12 + log(O/H) < 9, and at larger metallicities the trend flattens and even reverses, with the SFH being a plausible underlying driver for this behavior. The dust-to-gas ratio is also well correlated with metallicity and therefore decreases with galactocentric radius. Although most of the total emitted IR power (especially in the outer regions of disks) is contributed by dust grains heated by diffuse starlight with a similar intensity as the local Milky Way radiation field, a small amount of the dust mass (∼1%) is required to be exposed to very intense starlight in order to reproduce the observed fluxes at 24 μm, accounting for ∼10% of the total integrated IR power.
Success and the TV industry : how practitioners apprehend the notion(s) of success in their discourses within the Anglophone transatlantic television industry

This thesis explores the discourses of success within the Anglophone transatlantic television industry through the semi-structured interviews of sixteen industry practitioners. The TV industry has long been studied in media studies, its working conditions discussed in production studies, its texts scrutinised in TV studies; but what drives the TV industry? What is ‘success’ to television industry practitioners? How do they apprehend it and discuss it? Looking at this key element through those at the heart of it is this research’s purpose, and a necessary step for cultural, production and television studies to better comprehend the industry and what drives it and its members. After discussing the methods selected for this research and bringing forth a new, sevenfold taskbased industry categorisation, my research will tackle its subject of enquiry through three main topics: •the perception of decision-makers by industry practitioners •the industrial executive discourses of success among the different industry constituents (networks/cable/premium/public channels/studios); •the personal definitions of success of all practitioners (and their link to industrial/professional success). This research will engage with many academic fields: from discourse analysis and industrial sociology to organisational research and management psychology, through production studies, cultural studies and film/television/media studies, giving it a clearly multidisciplinary scope. With this thesis, I also wish to further help bridge the gap between academic and industrial expertise. By doing so, and making sense of industrial and personal ideas of success, my research aims at developing a new framework for it, thereby proposing to academics a first approach to the notion of success in this industry.
Dissolved iron in the Arctic shelf seas and surface waters of the central Arctic Ocean : Impact of Arctic river water and ice-melt

Key Points - DFe in the Arctic shelves and surface is linked to freshwater and alkalinity - Fluvial input main contributor to high DFe, low alkalinity in Central Arctic - Remineralisation and biological depletion determine DFe in the Arctic Shelf Seas Abstract Concentrations of dissolved ( 10 nM) in the bottom waters of the Laptev Sea shelf may be attributed to either sediment resuspension, sinking of brine or regeneration of DFe in the lower layers. A significant correlation (R2 = 0.60) between salinity and DFe is observed. Using δ18O, salinity ,nutrients and total alkalinity data, the main source for the high (>2 nM) DFe concentrations in the Amundsen and Makarov Basins is identified as (Eurasian) river water, transported with the Transpolar Drift (TPD). On the North American side of the TPD, the DFe concentrations are low ( 4) above the shelf and low ( < 4) off the shelf).
EXOPLANET TRANSIT SPECTROSCOPY USING WFC3: WASP-12 b, WASP-17 b, AND WASP-19 b

We report an analysis of transit spectroscopy of the extrasolar planets WASP-12 b, WASP-17 b, and WASP-19 b using the Wide Field Camera 3 (WFC3) on the Hubble Space Telescope (HST). We analyze the data for a single transit for each planet using a strategy similar, in certain aspects, to the techniques used by Berta et al., but we extend their methodology to allow us to correct for channel- or wavelength-dependent instrumental effects by utilizing the band-integrated time series and measurements of the drift of the spectrum on the detector over time. We achieve almost photon-limited results for individual spectral bins, but the uncertainties in the transit depth for the band-integrated data are exacerbated by the uneven sampling of the light curve imposed by the orbital phasing of HST's observations. Our final transit spectra for all three objects are consistent with the presence of a broad absorption feature at 1.4 μm most likely due to water. However, the amplitude of the absorption is less than that expected based on previous observations with Spitzer, possibly due to hazes absorbing in the NIR or non-solar compositions. The degeneracy of models with different compositions and temperature structures combined with the low amplitude of any features in the data preclude our ability to place unambiguous constraints on the atmospheric composition without additional observations with WFC3 to improve the signal-to-noise ratio and/or a comprehensive multi-wavelength analysis.
Outliers cleaning in dynamic systems

of the Thesis Outliers Cleaning in Dynamic Systems by Yuexi Zhang Master of Science in Electrical and Computer Engineering Northeastern University, April 2017 Dr. Octavia I. Camps, Advisor In this thesis, we focused on solving the problem of detecting and cleaning outliers when estimating human poses in a temporal sequence. We addressed this challenge by formulating optimization problems that use properties of dynamic systems explaining the temporal data. In particular, we solved this problem using two different approaches. In the first approach, we assumed that the data was generated by an underlying, but unknown, dynamic system. So, we designed a framework which combined a distance-like function of the Hankel matrix constructed by measurements to detect sharp changes with a data Interpolation algorithm. In the second approach, we also incorporated apriori knowledge of the underlying dynamics. In this case, it was assumed that training data is available to learn the underlying dynamics. Then, trajectories were cleaned while respecting this apriori knowledge. We tested the proposed approaches using both synthetic and real data from video sequences. Experiments showed that our approaches had better performances.
Spectroscopy of mesons containing two heavy quarks 1 95 . Spectroscopy of Mesons Containing Two Heavy Quarks

A golden age for heavy quarkonium physics dawned at the turn of this century, initiated by the confluence of exciting advances in quantum chromodynamics (QCD) and an explosion of related experimental activity. The subsequent broad spectrum of breakthroughs, surprises, and continuing puzzles had not been anticipated. Since that time CLEO-c, BESIII and the B-factories, recently joined by ATLAS, CMS and LHCb, have continued to make groundbreaking observations. For an extensive presentation of the status of heavy quarkonium physics, the reader is referred to several reviews [1–13]. This note focuses on experimental developments in heavy quarkonium spectroscopy with very few theoretical comments. Some other comments on possible theoretical interpretations of the states not predicted by the quark model are presented in the minireview on non-qq̄ states. Note that in this review we follow the new naming scheme for hadrons (see the review “Naming scheme for hadrons” in the current edition).
THE MEASUREMENT OF THE A CTOR ’ S F ORMANT IN FEMALE VOICES

The Actor’s Formant in professional male actors has been a subject of research for many years. It is a strong energy peak that lies in the frequency band between 3-4 kHz in the long-term average spectrum (LTAS) of a professional male actor’s voice. Results of perceptual analysis have shown that this concentration of energy has a correlation with the perceived voice quality. While the Actor’s Formant has been extensively studied in male subjects, there is little research pertaining to the Actor’s Formant in female voices. The aim of this study is to show evidence of the formation of an Actor’s Formant in the voices of females as a result of a short vocal warm-up exercise. LTAS results of six female subjects are analyzed and a significant increase in magnitudes of their spectra after the vocal warm up is observed in the region of 4-5 kHz. The study also proposes an experimental method to measure vocal tract transfer functions using transcutaneous excitation of vocal tract. The resulting transfer functions of the subjects are plausible and encourage further studies of formants in female actors and the general population as a whole using the proposed method.
Why Isn't the Whole of Spain Industrialized? New Economic Geography and Early Industrialization, 1797–1910

Spain provides an opportunity to study the causes of regional differences in industrial development over the nineteenth century. As transportation costs decreased and barriers to domestic trade were eliminated, Spanish manufacturing became increasingly concentrated in a few regions. This article combines Heckscher-Ohlin and economic-geography frameworks and finds that comparative-advantage and increasing-return effects were economically very significant and practically explained all differences in industrialization levels across regions. The deficits of some regions in terms of industrialization appear to have been largely attributable to their factor endowments and the absence of home-market effects for modern industries.
Health Risk Assessment of Heavy Metals via Dietary Intake of Vegetables Irrigated With Treated Wastewater around Gaborone , Botswana

Heavy metal concentrations of Cd, Cr, Cu, Ni, Pb and Zn in green peppers (Capsicum annuum) and tomatoes (Solanum lycopersicum) irrigated with treated wastewater from the Glen Valley farms were determined. Concentrations of Cr, Pb and Zn were significantly high when compared with their respective recommended safe limits prescribed by the Joint WHO/FAO Food Standards Program Code Alimentarius Commission. The daily intake of metals, DIM values for Cr and Pb were also found to be higher than their recommended safe limit values, whereas those for Cd, Cu and Ni were within the safe limit values while that for Zn was far below the recommended safe limit value. In this study, we expect that consumption of Cr and Pb through vegetables poses substantial health risk to consumers and for this reason, these products are probably not recommended consumption. Therefore, this emphasizes the need for proper method to manage using wastewater to reduce the health risk and the extent of heavy metals contamination. Keywords—Cluster Analysis, Daily Intake of Metals, Health Risk Index, Normalised Enrichment Factors
Oral health difficulties in children and adolescents with autism spectrum disorder: Parental perception

aim to investigate difficulties related to appointments that be comparison Methods A 48-item questionnaire was prepared for the purpose of the study and distributed to parents of children and adolescents with ASD in three specialized daycare centers, as well as to parents of typically developing children and adolescents at the Clinic for Pediatric and Preventive Dentistry in Belgrade, Serbia. Ninety-two questionnaires were considered and statistically analyzed in the SPSS program, using χ 2 and Mann–Whitney U-test. Results The following statistically significant differences were found between children and adolescents with ASD and their typically developing peers: general difficulties in everyday oral hygiene, need of help for basic oral hygiene tasks, tooth brushing frequency, sensory difficulties related to toothbrush and toothpaste, level of anxiety prior to dental appointment, cooperation during appointment, sensory difficulties related to touch, operatory light and sound of dental unit, number of treatments under general anesthesia, and the number of refused dental treatments. in order to enable quality dental care.
2979 Incentives , Reputation and the Allocation of Authority Abstract

We address the question how much authority a principal should delegate to a manager with conflicting interests and uncertain ability in a context in which the manager has both compensation-based and reputational incentives. The optimal level of authority balances the value of the manager's decision-making expertise against the cost of ensuring that the manager uses his discretion productively. Reputational incentives reduce the necessary monetary incentives to discourage purely opportunistic behavior, but may cause the manager to pursue conservative courses of action to preserve his reputation. This undermines the benefits of delegating control, leading to decreased managerial authority and stronger monetary incentives. When the principal can commit to long-term contracts, she eliminates this conservative bias by rewarding a successful manager with greater future compensation and authority than would be optimal in a static setting. Early in the relationship the principal may delegate additional authority in order to screen for managers of high ability. JEL-Code: D86, L14, L23, M52, M54.
Five-Year Wilkinson Microwave Anisotropy Probe ( WMAP 1 ) Observations : Data Processing , Sky Maps

We present new full-sky temperature and polarization maps in five frequency bands from 23 to 94 GHz, based on data from the first five years of the W M A P sky survey. The new maps are consistent with previous maps and are more sensitive. The five-year maps incorporate several improvements in data processing made possible by the additional years of data and by a more complete analysis of the instrument calibration and in-flight beam response. We present several new tests for systematic errors in the polarization data and conclude that W band polarization data is not yet suitable for cosmological studies, but we suggest directions for further study. We do find that Ka band data is suitable for use; in conjunction with the additional years of data, the addition of Ka band to the previously used Q and V band channels significantly reduces the uncertainty in the optical depth parameter, T . Further scientific results from the five year data analysis are presented in six companion papers and are summarized in §7 of this paper. With the 5 year lVAIAP data, we detect no convincing deviations from the minimal 6parameter ACDhI model: a flat universe dominated by a cosmological constant. with adiabatic ' WLIAP is the result of a partnership between Princeton University and NASA's Goddard Space Flight Center. Scientific guidance is provided by the WbIAP Science Team. 2Code 665, NASAIGoddard Space Flight Center. Greenbelt, hID 20771 3Adnet Systems, Inc. 7515 hlission Dr., Suite A100 Lanham, Maryland 20706 ' ~ e ~ t . of Physics & Astronomy. The Johns Hopkins University. 3400 N. Charles St., Baltimore, hID 21218-2686 w e p t . of Physics, Jadwin Hall. Princeton University, Princeton, NJ 08544-0708 6Dept. of Astrophysical Sciences, Peyton Hall, Princeton University, Princeton, NJ 08544-1001 7Astrophysics, University of Oxford. Keble Road, Oxford, OX1 3RH, UK 'Univ. of Texas, Austin. Dept. of Astronomy, 2.511 Speedway, RLkI 15.306, Austin, TX 78712 'Canadian Institute for Theoretical Astrophysics. 60 St. George St, University of Toronto, Toronto, ON Canada h15S 3H8 "Princeton Center for Theoretical Physics, Princeton University. Princeton, NJ 08544 llDept. of Physics and Astronomy, University of British Columbia, Vancouver, BC Canada V6T 1Z1 12Columbia Astrophysics Laboratory. 550 W. 120th St., Mail Code 5247, New York, NY 10027-6902 13Depts. of Astrophysics and Physics, KICP and EFI; University of Chicago, Chicago, IL 60637 "Dept. of Physics. Brown University, 182 Hope St., Providence, RI 02912-1843 I5UCLA Physics & Astronomy, PO Box 951547, Los Angeles, CA 90095-1547 https://ntrs.nasa. gov/search.jsp? R=20080032973 2020-02-01T01:57:49+00:00Z
MOLECULAR ALTERATIONS AND TARGETED THERAPY IN OESOPHAGEAL SQUAMOUS CELL CARCINOMA

Oesophageal cancer is one of the most fatal cancers. Oesophageal squamous cell carcinoma is the predominant histological subtype worldwide with a high incidence rate in Asia. Although significant advancement has been made in surgery and chemoradiotherapy, still it has a very dismal prognosis. These insights have led to the new-found interest into the molecular alterations that may occur in Oesophageal squamous cell carcinoma with the objectives to discover novel biomarkers for improving and guiding targeted therapy. Many molecular alterations may occur in oesophageal carcinogenesis. Basically they are of two types: oncogenes and tumour suppressor genes. Oncogenes related to ESCC are growth factors, growth factor receptors, signal transducers and nuclear factors. Among the tumour suppressor genes, the important ones are p53, Rb, p16 and p21. In addition, there are genes related to apoptosis and metastasis. This review summarizes all these genes and their deregulated proteins, which have proved to have strong prognostic and therapeutic implications in these patients.
Recovery of equine oocytes by scraping of the follicular wall with different specifications of needles and morphological analysis of cumulus oophorus

Na obtencao de oocitos para a especie equina, aspectos fisicos sao de alta significância para o sucesso da tecnica, como a pressao de vacuo e o calibre de agulha utilizado, alem da forma como e realizada a raspagem da parede folicular. O objetivo deste estudo foi investigar o indice de recuperacao de oocitos equinos aspirados pela tecnica de raspagem da parede folicular, testando calibres distintos de agulhas descartaveis, assim como avaliacao morfologica dos complexos cumulus oophorus (CCOs). Foram utilizados ovarios de eguas (n=447), obtidos em abatedouro local, transportados ao laboratorio em recipiente termico (20 oC) e submetidos a dissecacao da tunica albuginea e tecidos conectores. Os foliculos aspirados obtinham diâmetro entre 10 mm a 25 mm, e para tanto utilizou-se a agulha 30x8 (21G 1 ¼) ou 40x12 (18G 1 ½), formando respectivamente, o grupo A (G-A) e grupo B (G-B). No G-A e G-B aspiraram-se 480 e 548 foliculos, respectivamente. Sob lupa estereo-microscopica avaliou-se os oocitos quanto a qualidade do ooplasma e caracteristicas das celulas do cumulus oophorus (grau I, II, III e desnudo). Para analise estatistica utilizou-se teste t Student, regressao logistica e teste de proporcoes, e as diferencas foram consideradas significativas quando P<0,05. A taxa de recuperacao entre G-A e G-B nao apresentou diferenca; 66,5% (330/496) e 65,5% (359/548), respectivamente. Houve diferenca quanto a qualidade dos oocitos no G-A, no qual os oocitos de grau II obtiveram melhor taxa (46,9%; 145/330; P<0,05) frente ao grau I (23,6%; 72/330), grau III (20,6%; 59/330) e desnudo (8,5%; 24/330). Entretanto, no G-B nao houve diferenca estatistica quanto aos graus de qualidade do CCOs recuperados, grau I (23,4%; 77/359), grau II (43,2%; 145/359), grau III (22,5%; 73/359) e desnudo (11,1%; 32/359). A agulha 30x8 (21G 1 ¼) porporcionou maior proporcao de oocitos de grau I e II aspirados do que a agulha 40x12 (18G 1 ½), com 72,4% (239/330) e 65% (233/359; P<0,05), respectivamente. Ambos os calibres de agulhas testados proporcionam taxas eficientes de recuperacao de oocitos. A aspiracao com agulha 30x8 (21G 1 ¼) apresentou maior proporcao de oocitos equinos de melhor qualidade morfologica para aplicacao em biotecnicas reprodutivas.
CDC's Approach to Educating Coaches about Sports-related Concussion

Abstract Sports-related concussions can happen to any athlete in any sport. Each year in the United States, an estimated 1.6-3.8 million sports and recreation-related traumatic brain injuries (TBIs) occur, most of which can be classified as concussions. To help coaches prevent, recognize, and better manage sports-related concussions, the Centers for Disease Control and Prevention's (CDC) National Center for Injury Prevention and Control (CDC's Injury Center) applied a comprehensive health-education approach to developing a multimedia tool kit for high school athletic coaches. From developing an expert panel and pretesting message concepts to pilot testing, promoting, and evaluating the final product, CDC has shown that this undertaking is highly effective. Results of the pilot study and promotion efforts show that the tool kit is well received by coaches and school officials and that it meets a critical health education need.