Miracle-dz/UniFAR-FTUs huggingface dataset:
Differentiating among insecure mother - infant attachment classifications: A focus on child - friend interaction and exploration during solitary play at 36 months

Utilizing data from the NICHD Study of Early Child Care, the primary objective of the current report was to examine how avoidant and resistant mother-infant attachment classifications at 15 months were differentially associated with children's interaction with a same-sex friend and exploration during solitary play at 36 months. The added contributions of attachment security at 36 months and maternal sensitivity from 6 to 36 months to the prediction of child outcomes were also explored. As hypothesized, an avoidant attachment history was related to more instrumental aggression during child-friend interaction, whereas a resistant attachment history was associated with less self-assertion/control among friends and less attention and pretend play during exploration. Maternal sensitivity and concurrent attachment security also made unique contributions to the prediction of child outcomes at 36 months, although associations with 15-month attachment remained significant when these subsequent measures of the mother-child relationship were considered. Few differences emerged for the disorganized mother-infant attachment category in this relatively low-risk sample. Results underscore the need to differentiate between avoidant and resistant attachment groups and illustrate how early attachment history and subsequent indices of the mother-child relationship contribute to children's functioning.
The Malevolent Side of Revenge Porn Proclivity: Dark Personality Traits and Sexist Ideology

This paper presents a novel study, exploring a form of technology facilitated sexual violence TFSV known as revenge porn. Despite its emerging prevalence, little is known about the characteristics of revenge porn perpetrators. In the current study, a revenge porn proclivity scale was devised to examine participants' behavioural propensity to engage in revenge porn. One hundred adults, aged 18-54, were recruited online from a community sample. The correlational relationship between revenge porn proclivity and the self-reported endorsement of the Dark Triad, sadism, and ambivalent sexism was examined. Additional proclivity subscales of revenge porn enjoyment and revenge porn approval were also created. The study's main findings revealed a positive correlation between a greater behavioural propensity to engage in revenge porn and higher levels of the Dark Triad and ambivalent sexism. Moreover, endorsement of psychopathy was found to be the only Dark Triad trait that independently predicted revenge porn proclivity. The results suggest that perpetrators of revenge porn may have distinct personality profiles. Limitations and directions for future research are discussed.
Multifocal adenoid cystic carcinoma of the breast: an unusual presentation.

denoid cystic carcinomas (ACCs)constitute 0.1%–1% of all malignantbreast tumours. They have better prog-nosis than other breast masses: they usu-ally do not metastasize, and treatment isusually followed by prolonged survival.We present a case of multifocal, focallyinfiltrating ACC of the breast. A searchof the English literature failed to revealany other such case.Case reportAn 83-year-old woman was seen with amass in her left breast that had been pre-sent for 20 years. She complained ofrapid enlargement of this mass over theprevious 2 months. She had undergonetotal abdominal hysterectomy and bilat-eral salpingo-oophorectomy 45 yearsearlier. Her medical history revealed thatfor the last 20 years she had controlleddiabetes and coronary artery disease.Breast examination revealed 2 palpablemasses in the upper lateral quadrantmeasuring 8 ×7 cm and 4 3 cm. Noaxillary lymphadenopathy was detected.Ultrasonography identified 3 similarmacrolobulated solid lesions with irregu-lar contours (7 ×6 3 cm, 4 2 cm and2 × 1 cm in dimension, respectively). Adjacent to these masses were severalhypoechoic masses, the largest having adiameter of 10 mm. We could not deter-mine whether these were round satellitelesions or metastatic intramammarianlymph nodes. Mammography revealed 3macrolobulated masses with irregularcontours: a 7 × 6-cm mass located in theupper lateral quadrant of the left breast, a4 × 2-cm mass superior to this and adja-cent to the axillary tail, and adjacent to thelatter, another 3 × 2-cm mass that couldnot be clearly evaluated owing to super-position (Fig. 1). Pathological examina-tion of a tru-cut biopsy specimen identi-fied an invasive ductal carcinoma withfocal intraductal carcinoma. A modifiedleft radical mastectomy was performed.Pathological examination of the surgicalspecimen revealed 2 multifocal adenoidcystic carcinomas, 5.5 cm and 2.5 cm, respectively, in greatest diameter (Fig. 2)
Human Leukocyte Antigen Class I and Class II Allele Frequencies and HIV-1 Infection Associations in a Chinese Cohort

Summary:China has one of the most rapidly spreading HIV-1 epidemics. To develop a vaccine targeted to specific human leukocyte antigen (HLA) epitopes in this population, allele distribution analysis is needed. We performed low-resolution class I and II HLA typing of a cohort of 393 subjects from mainland China using a polymerase chain reaction with sequence-specific primers (PCR-SSPs). We found 10 class I alleles present in more than 10% of the population: HLA-A*02, HLA-A*11, HLA-A*24, HLA-B*13, HLA-B*15, HLA-B*40, HLA-Cw*03, HLA-Cw*07, HLA-Cw*01, and HLA-Cw*06. Several class II alleles were found at high frequency (≥10%): HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-DRB1*0701, HLA-DRB1*1501, HLA-DRB1*0401, HLA-DRB1*0901, HLA-DRB1*1201, HLA-DQB1*0601, HLA-DQB1*0301, HLA-DQB1*0201, HLA-DQB1*0501, and HLA-DQB*0303. We also estimated 2- and 3-locus haplotype frequencies. Because this cohort contained 280 HIV-1-seropositive and 113 HIV-1-seronegative individuals, we compared allele and haplotype frequencies between the infected and control groups to explore correlations between HLA antigens and susceptibility/resistance to HIV infection. The HLA-B*14 allele was only found in the HIV-1-seropositive group, and many 2-locus haplotypes were significantly overrepresented in this group: HLA-B*14/Cw*08, HLA-B*51/Cw*14, HLA-A*02/B*13, HLA-A*31/Cw*14, HLA-A*02/Cw*06, and the class II haplotype HLA-DRB1*1301/DQB1*0601. Alleles significantly increased in the HIV-1-seronegative controls were HLA-B*44, HLA-Cw*04, and HLA-DRB1*1402. Overrepresented 2-locus haplotypes in the control group were HLA-B*44/Cw*04, HLA-A*31/Cw*03, HLA-A*03/Cw*07, HLA-A*11/B*13, HLA-A*11/B*38, HLA-A*24/B*52, and HLA-A*11/Cw*01. The 3-locus haplotypes HLA-A*24/Cw*03/B*40 and HLA-A*02/B*15/DRB1*1201 were found to be increased significantly in the control group. These data contribute to the database of allele frequencies and associations with HIV infection in the Chinese population.
Influence of the tyrosine hydroxylase val81met polymorphism and catechol‐O‐methyltransferase val158met polymorphism on the antidepressant effect of milnacipran

Genetic polymorphisms of the noradrenergic pathway can be factors to predict the effect of antidepressants when their pharmacological mechanisms of action include the noradrenergic system. The purpose of the present study was to determine whether the tyrosine hydroxylase (TH) val81met and catechol‐O‐methyltransferase (COMT) val158met polymorphisms are associated with the antidepressant effect of milnacipran, a serotonin/noradrenaline reuptake inhibitor.
LOOP-MEDIATED ISOTHERMAL AMPLIFICATION ASSAY FOR RAPID AND SENSITIVE DETECTION OF PESTE DES PETITS RUMINANTS VIRUS IN FIELD CONDITIONS

Eradication of Peste des petits ruminants (PRR) is currently the center of attention of the Food and Agriculture Organization (FAO). The key to success of efforts put in eradication of PPR are hidden in efficient and sensitive diagnosis of the PPR. For thedetection of PPR virus (PPRV), molecular methods such as reverse-transcription PCR (RTPCR) and loop-mediated isothermal amplification (LAMP) are preferred over serological assaysbecause to their higher sensitivity and specificity. However, molecular techniques are time consuming and require sophisticated laboratories for viral RNA extraction, reverse transcription, amplification and analysis steps. In the present study, single tube, LAMP was successfully established by incubating virus cultures or clinical sampleswitha special LAMP buffer and an amplification reaction system at 63°C for sixty minutes under isothermal conditions. In the test, the ESE-Quant tube scanner was used as heating block and fluorescenceanalyzer that can easily be operated in the field conditions by using rechargeable batteries. The new PPRV-LAMP setup excludes the need for pre-requisite steps of total RNA extraction and reverse transcription prior to the amplification of target viral genome and post amplification lengthy analysis by gel electrophoresis, thereby, providing with the option of field based sensitive, reliable and efficient molecular diagnosis of PPRV.Thesensitivity and reliability of the LAMP was compared with conventional RT-PCR. The amplified LAMP products were confirmed by both naked eye visualization and agarose gel electrophoresis.This power independent simplistic technology would result in the ease of PPRV diagnosis especially in the far from areas of disease endemic countries like Pakistan. In conclusion, this study provides an important field based molecular diagnostic tool for the detection and surveillance of PPRV.
Diverting Subjects' Concentration Slows Figural Reversals

Earlier research has shown that subjects are slower to discover the alternative construal of ambiguous geometric figures if they are simultaneously engaged in distractor tasks. Results are reported which show that this effect slows reversals subsequent to the first reversal, and is therefore not merely slowing the discovery of the alternative construal. In addition, the magnitude of the distraction effect seems unchanged through the successive reversals. The results are discussed in terms of their implications for figural reversal and of their implications for the role of mental resources in perceiving.
Transoral Robotic Surgery

Objective (1) To determine baseline demographic, geographic, clinical, and pathologic characteristics of patients who had transoral robotic surgery (TORS) for oropharyngeal cancer. (2) To analyze margin status and unplanned readmission after TORS versus nonrobotic surgery. Study Design Retrospective database review. Setting National Cancer Database (2010-2011). Subjects and Methods Searching the National Cancer Database for adults with oropharyngeal cancer, we identified 877 patients who had TORS and 4269 patients who had nonrobotic surgery. Outcomes of interest included likelihood of adjuvant therapy, margin status, and unplanned readmission. Statistical analysis included chi-square, t tests, and multivariate regression. Results From 2010 to 2011, there was a 67% increase in the use of TORS for oropharyngeal cancer. Compared with patients who had nonrobotic surgery, TORS patients were more likely to be at academic centers (80.8% vs 49.1%, P < .001), to have private insurance (62.2% vs 57.4%, P < .001), and to have human papilloma virus (HPV)–positive tumors (48.3% vs 27.1%, P < .001). TORS (odds ratio, 0.50; 95% CI, 0.39-0.63) and HPV positivity (odds ratio, 0.73; 95% CI, 0.53-0.99) were independently associated with decreased likelihood of adjuvant chemoradiation versus radiation therapy. TORS patients were less likely to have positive margins than were patients who had nonrobotic surgery (20.2% vs 31.0%, P < .001). High-volume TORS centers had lower rates of positive margins (15.8% vs 26.1%, P < .001) and unplanned readmissions (3.1% vs 6.1%, P < .03) than did low-volume centers. Conclusions TORS is being rapidly adopted by academic and community cancer centers. TORS is associated with a lower rate of positive margins than nonrobotic surgery, and high-volume centers have the lowest rates of positive margins and unplanned readmissions.
Correcting and Speeding-Up Bounds for Non-Uniform Graph Edit Distance

The problem of deriving lower and upper bounds for the edit distance between labelled undirected graphs has recently received increasing attention. However, only one algorithm has been proposed that allegedly computes not only an upper but also a lower bound for non-uniform metric edit costs and incorporates information about both node and edge labels. In this paper, we show that this algorithm is incorrect in the sense that, in general, it does not compute a lower bound. We present BRANCH, a corrected version of the algorithm that runs in O(n5) time. We also develop a speed-up BRANCHFAST that runs in O(n4) time and computes a lower bound, which is only slightly less accurate than the one computed by BRANCH. An experimental evaluation shows that BRANCH and BRANCHFAST yield excellent runtime/accuracy-tradeoffs, as they outperform all existing competitors in terms of runtime or in terms of accuracy.
Quality of life in gastric cancer.

AIM To summarize the empirical research on assessing quality of life (QOL) in patients with gastric carcinoma. METHODS Literature searches were conducted in MedLine from 1966 to February 2004. RESULTS Twenty-six studies were identified. QOL was used as an outcome measure in virtually all identified studies, such as those examining the effects of gastric cancer and various medical or surgical treatments in the patients. QOL was assessed mainly with generic measures; the social dimensions of QOL were largely neglected. The lack of gastric cancer-specific QOL measures hampers QOL research up to now. The gastric cancer-specific EORTC-QLQ-STO22 and the FACT-Ga are important additions to the arsenal of disease-specific QOL measures. In most of the studies, the label QOL is used for questionnaires, which only assess symptoms or performance status, or are physician-reported rather than patient-reported outcomes. CONCLUSION QOL in patients with gastric cancer deserves more systematic studies, especially as one of the outcome measures in randomized clinical trials. Results of studies that include QOL in patients with gastric cancer should be applied in clinical care, which aims at improving QOL of these patients.
The relationship between antibody affinity and the efficiency of complement fixation.

The efficiency of complement fixation by antigen-antibody complexes is shown for the first time to be directly related to the affinity of IgG antibody for its antigenic determinant. Decreased complement fixation by IgG antibody at 37°C is independent of antibody affinity. The biologic activity of the complexes in terms of complement fixation parallels their activity in the passive cutaneous anaphylaxis reaction. The implications of these observations with respect to the mechanisms of complement fixation by immune complexes formed with IgG antibody are discussed.
The Human U5-220kD Protein (hPrp8) Forms a Stable RNA-Free Complex with Several U5-Specific Proteins, Including an RNA Unwindase, a Homologue of Ribosomal Elongation Factor EF-2, and a Novel WD-40 Protein

ABSTRACT The human small nuclear ribonucleoprotein (snRNP) U5 is biochemically the most complex of the snRNP particles, containing not only the Sm core proteins but also 10 particle-specific proteins. Several of these proteins have sequence motifs which suggest that they participate in conformational changes of RNA and protein. Together, the specific proteins comprise 85% of the mass of the U5 snRNP particle. Therefore, protein-protein interactions should be highly important for both the architecture and the function of this particle. We investigated protein-protein interactions using both native and recombinant U5-specific proteins. Native U5 proteins were obtained by dissociation of U5 snRNP particles with the chaotropic salt sodium thiocyanate. A stable, RNA-free complex containing the 116-kDa EF-2 homologue (116kD), the 200kD RNA unwindase, the 220kD protein, which is the orthologue of the yeast Prp8p protein, and the U5-40kD protein was detected by sedimentation analysis of the dissociated proteins. By cDNA cloning, we show that the 40kD protein is a novel WD-40 repeat protein and is thus likely to mediate regulated protein-protein interactions. Additional biochemical analyses demonstrated that the 220kD protein binds simultaneously to the 40- and the 116kD proteins and probably also to the 200kD protein. Since the 220kD protein is also known to contact both the pre-mRNA and the U5 snRNA, it is in a position to relay the functional state of the spliceosome to the other proteins in the complex and thus modulate their activity.
Detection of receptor-specific murine leukemia virus binding to cells by immunofluorescence analysis

Four classes of murine leukemia virus (MuLV) which display distinct cellular tropisms and bind to different retrovirus receptors to initiate virus infection have been described. In the present study, we describe a rapid, sensitive immunofluorescence assay useful for characterizing the initial binding of MuLV to cells. By using the rat monoclonal antibody 83A25 (L. H. Evans, R. P. Morrison, F. G. Malik, J. Portis, and W. J. Britt, J. Virol. 64:6176-6183, 1990), which recognizes an epitope of the envelope gp70 molecule common to the different classes of MuLV, it is possible to analyse the binding of ecotropic, amphotropic, or xenotropic MuLV by using only a single combination of primary and secondary antibodies. The MuLV binding detected by this assay is envelope receptor specific and matches the susceptibility to infection determined for cells from a variety of species. The binding of amphotropic MuLV to NIH 3T3 cells was shown to be rapid, saturable, and temperature dependent. Chinese hamster ovary (CHO-K1) cells normally lack the ability to bind ecotropic virus and are not infectible by ecotropic vectors. Expression of the cloned ecotropic retrovirus receptor gene (Rec) in CHO-K1 cells confers high levels of ecotropic virus-specific binding and confers susceptibility to infection. Characterization of MuLV binding to primary cells may provide insight into the infectibility of cells by retroviruses and aid in the selection of appropriate vectors for gene transfer experiments.
Suppression of babesiosis in BCG-infected mice and its correlation with tumor inhibition

Infection of mice with Bacillus Calmette-Guérin (BCG) provided good protection against Babesia species. The intensity and duration of this protection was similar to that established after natural recovery from babesiosis. It developed too soon after the first exposure to the parasite, and was too radioresistant, to be attributable to specific antibody production. In addition, the parasites degenerated within circulating erythrocytes. This phenomenon is inconsistent with phagocytosis or lysis of parasites or parasitized cells, or prevention of entry of parasites into erythrocytes, causing the observed protection. Hence the phenomenon is best explained by the release of a nonspecific mediator that can limit multiplication of parasites within erythrocytes. These results not only throw light on mechanisms of immunity against hemoprotozoa. There are many points of similarity between the nonspecific protection BCG and Corynebactium parvum provide against Babesia species and inhibition of tumor growth by these agents. Therefore, babesiosis in mice may be a convenient experimental model for assessing stimulation of the mononuclear phagocyte system, which appears to be the basis of nonspecific immunity against bacteria, parasites, and tumors.
Numerical simulations of ice-covered EHV post station insulator performance equipped with booster sheds

The main objective of this paper is to study numerically the influence of addition of 6 booster sheds (BS) to 2 units of EHV porcelain post insulator on their electrical performance under severe wet-grown ice accumulation based on experimental results. The numerical investigations have been carried out during melting period in order to determine the potential and electric field distributions and the voltage drop along the different air gaps resulting from the addition of BS. Numerical simulations were done using the finite element method (FEM). Adding BS helps to created artificially air gaps which length depends on their position along the ice-covered insulator. Numerical simulations have helped to demonstrate that voltage drop repartition along the different air gap is not uniform. In particularly, it was shown that more that 53% of the applied voltage is concentrated along the first air gap closed to the HV electrode, which also the longest. Also, it was demonstrated that numerical simulations can be useful and an interesting alternative to experimental test in order to improve and optimize the use of BS for improving electrical performance of post insulator under severe icing conditions.
Changes in Chinese Discharged Chronic Mental Patients Attending a Psychiatric Rehabilitation Program with Holistic Care Elements: A Quasi-Experimental Study

This study attempted to examine the changes and related factors in discharged chronic mental patients attending a psychiatric rehabilitation program in Hong Kong adopting a self-help group (SHG) approach with holistic care emphases on the physical, psychological, social, and spiritual functioning of the program participants. A quasi-experimental design involving an experimental group (109 participants attending the program) and a control group (154 patients from a psychiatric outpatient clinic who had never attended any SHG before) was adopted with the participants responding to measures assessing their functioning in the physical, psychological, social, and spiritual domains. Results showed that those who joined the SHG with holistic care elements had more friends and more social satisfaction than the control subjects. Duration of attendance, religious involvement, and group involvement were three key factors related to the outcomes of the program participants. This pioneering study provides support for the effective use of the SHG approach with holistic care elements to help discharged chronic mental patients in the Chinese culture.
A novel ascorbic acid-resistant nitroxide in fat emulsion is an efficient brain imaging probe for in vivo EPR imaging of mouse

Abstract The loss of paramagnetism of nitroxide radicals due to reductant reactions in biological systems, places a fundamental time constraint on their application as an imaging probe in in vivo EPR imaging studies. However, in vitro studies of the newly synthesized tetraethyl-substituted piperidine nitroxide radical demonstrated high resistivity to paramagnetic reduction when exposed to ascorbic acid, a common reduction agent in biological systems. In this work we investigated the use of these nitroxides as an imaging probe in EPR imaging of small rodents. 2,2,6,6-Tetraethyl-piperidine nitroxide (TEEPONE) is not highly soluble in aqueous media, thus a lipid-based emulsion system of lecithin was used to solubilize TEEPONE. The obtained solution was homogenous and with low viscosity, allowing smooth intravenous injection into mice tail vein. Acquired three dimensional (3D) EPR images of mouse head clearly showed TEEPONE distributed in all tissues including brain tissues, with an average measurable signal half-life of more than 80 min, thus demonstrating high resistivity to reduction due to ascorbic acid in in vivo animal studies, and the potential for use of this compound in in vivo studies of animal model systems.