Miracle-dz/UniFAR-FTUs huggingface dataset:
A Neural “Tuning Curve” for Multisensory Experience and Cognitive-Perceptual Schizotypy

Our coherent perception of external events is enabled by the integration of inputs from different senses occurring within a range of temporal offsets known as the temporal binding window (TBW), which varies from person to person. A relatively wide TBW may increase the likelihood that stimuli originating from different environmental events are erroneously integrated and abnormally large TBW has been found in psychiatric disorders characterized by unusual perceptual experiences. Despite strong evidence of inter-individual differences in TBW, both within clinical and nonclinical populations, the neurobiological underpinnings of this variability remain unclear. We adopted an integrated strategy linking TBW to temporal dynamics in functional magnetic resonance imaging (fMRI)-resting-state activity and cortical excitation/inhibition (E/I) balance. E/I balance was indexed by glutamate/Gamma-AminoButyric Acid (GABA) concentrations and common variation in glutamate and GABA genes in a healthy sample. Stronger resting-state long-range temporal correlations, indicated by larger power law exponent (PLE), in the auditory cortex, robustly predicted narrower audio-tactile TBW, which was in turn associated with lower cognitive-perceptual schizotypy. Furthermore, PLE was highest and TBW narrowest for individuals with intermediate levels of E/I balance, with shifts towards either extreme resulting in reduced multisensory temporal precision and increased schizotypy, effectively forming a neural "tuning curve" for multisensory experience and schizophrenia risk. Our findings shed light on the neurobiological underpinnings of multisensory integration and its potentially clinically relevant inter-individual variability.
The impact of online financial disclosure and donations in nonprofits

ABSTRACT Decreased public confidence and trust in the nonprofit sector has fueled increased calls for transparency. In response, federal regulators and watchdog organizations have recommended that nonprofits voluntarily disclose their financial information on their own public websites. Despite the potential benefits of enhanced public confidence and trust, improved donor decision making, and increased donations, many nonprofit organizations have not adopted the recommended disclosure practices. We investigate the disclosure practices of 3,217 nonprofits and find that voluntary web disclosure of the IRS Form 990 is strongly correlated to donations, independent of other variables such as age, size, and fundraising expenditures. Further, fundraising is also clearly related to the performance indicators shown in the 990 disclosures, particularly the program ratio of program expenditures to total expenditures. This is true on a general level and when specifically compared to other nonprofits within particular sectors. As a result, nonprofits should seriously consider voluntarily posting their Form 990 results on their websites when it reflects favorably and strive to improve their financial performance if online disclosure would reflect poorly on the organization.
Evaluation of the safety and immunogenicity of a new, heat-treated human rabies immune globulin using a sham, post-exposure prophylaxis of rabies.

A double-blind, controlled, randomized trial was conducted to evaluate the safety and immunogenicity of a new human rabies immune globulin (HTRIG). This product, manufactured by Pasteur Merieux Connaught, PMC, has undergone a heat-treatment step (10 h at 60 degrees C) and removal of mercurothiolate. The corresponding unheated product available from the same manufacturer (human rabies immune globulin, HRIG, IMOGAM RABIES[spr2]) was used for comparison. These two rabies immune globulins (RIGs) were administered either alone or in association with the human diploid cell rabies vaccine (HDCV, IMOVAX[spr2] RABIES, PMC) according to a standard, post-exposure rabies prophylaxis schedule. Sixty-four healthy adults were randomly assigned to four groups of 16 to receive either HRIG/placebo, HTRIG/placebo, HRIG/HDCV or HTRIG/HDCV. RIG was administered at the recommended dose of 20 IU/kg by three intramuscular (i.m.) injections in the gluteus. HDCV or placebo was given on day (D) 0, D3, D7, D14, and D28 into the deltoid by the intramuscular (i.m.) route. Any local reaction from D0 to D3 at the immune globulin injection site, and any systemic reaction from D0 to D42, were monitored by subject diaries. Rabies-neutralizing serum antibody levels were assessed by the rapid fluorescent focus inhibition test (RFFIT) before treatment and on D3, D7, D14, D28, D35, and D42. No serious adverse reactions and, in particular, no allergic-type reactions were reported. The safety profiles of HTRIG and HRIG were similar, except that complaints of pain, or tenderness at the injection site were half as common in the HTRIG group. Most of the local reactions were mild or moderate. After the administration of HTRIG/placebo or HRIG/placebo, 60% of subjects had detectable rabies antibodies levels, but by D42 all titres were below the seroprotective level (i.e. below 0.5 IU/ml). In the groups HTRIG/HDCV and HRIG/HDCV, the antibody titres rose markedly from D7, and reached a maximum value of 19 IU/ml (95% CI, 11 to 38 IU/ml) and 31 IU/ml (95% CI, 20 to 48 IU/ml), respectively, on day 14. All subjects who received RIG and vaccine maintained a protective antibody level from D14 to D42. No significant difference in immunogenicity results between these two groups (HTRIG/HDCV and HRIG/HDCV) was observed, and no interference of immune globulin with vaccine was reported. The safety and immunogenicity profiles of PMC HTRIG appear comparable with the current reference product. The heat-treatment step will enhance the safety by further reducing the probability of virus transmission through immune globulin treatment. The low levels of rabies antibodies obtained by intramuscular administration of either PMC HTRIG or of PMC HRIG support the recommendations that call for local infiltration of wounds with RIG.
High frequency of multidrug‐resistant Staphylococcus aureus with SCCmec type III and Spa types t037 and t631 isolated from burn patients in southwest of Iran

Methicilin resistance Staphylococcus aureus (MRSA) infections are the major challenges in hospitals, especially in the burn units. The use of molecular typing methods is essential for tracking the spread of S. aureus infection and epidemiological investigations. The aim of this study was to find the profile of the spa types and also the prevalence of each SCCmec type of S. aureus strains in a central burn hospital in southwest of Iran. A total of 81 non‐duplicate S. aureus were isolated from burn patients between April 2011 and February 2012. The susceptibility of the isolates against 13 different antibiotics was tested by disk agar diffusion (DAD) method. MRSA strains were identified by amplification of mecA gene. Multiplex‐polymerase chain reaction (PCR) technique was used to determine the SCCmec types of MRSA strains and all the S. aureus isolates were typed by spa typing method. Detection of mecA gene showed that 70 (86.4%) of the isolates were MRSA. The highest rate of resistance was observed for penicillin (97.5%) and erythromycin (77.8%). None of the isolates were resistant to vancomycin. Sixty‐seven of the 70 MRSA isolates harbored only SCCmec type III and three untypeable isolates. Five different spa types were detected. The most common spa types were t037 (42.5%) and t631 (34.5%) and were only found in MRSA isolates. Only SCCmec type III was found in burn patients which emphasizes the HA‐MRSA origin of these strains. Only five different spa types identified in this study are in accordance with one SCCmec type which indicates that a limited number of bacterial colons are circulated in the burn unit in this hospital.
Expression of Nestin and CD133 in serous ovarian carcinoma.

Pupose: Nestin and CD133 are regarded as putative markers of cancer stem cells (CSCs) and related to poor prognosis in various cancer sites. Since few studies have focused on their role in ovarian cancer, we aimed to investigate their predictive value and association with neoangiogenesis. METHODS Immunohistochemical analysis for nestin and CD133 was performed on 85 serous ovarian carcinoma tumor samples using tissue microarray technique. Nestin immunoreactivity was detected in both tumor and endothelial cells, whilst CD133 was only identified in tumor cells. CD34 endothelial expression was used to assess intratumor microvessel density (MVD). RESULTS Of the tissue samples 49.4% were nestin-positive and 24.7% were positive for CD133. In both univariate and multivariate analysis nestin or CD133 expressions in tumor cells were not significantly associated with clinicopathological parameters (age, serum CA125, peritoneal carcinomatosis, malignant ascites, tumor grade). However, in multivariate analysis nestin expression in tumor cells proved to be an independent prognostic factor, associated with poorer survival and time to progression (p=0.025 and p=0.05, respectively). This has not been achieved for CD133. Furthermore, a significant concordance between nestin endothelial expression (nestin-determined MVD) and CD34-determined MVD was achieved. CONCLUSION In addition to the well-known clinicopathological characteristics, tumor expression of nestin might be a valuable prognostic factor for survival in patients with advanced ovarian cancer. With regard to its endothelial expression, nestin might be as reliable as CD34 for quantifying tumor angiogenesis. Further investigation is justified in order to better clarify the role of these biomarkers.
Factors Associated with the Use of Modern Contraceptive Methods by Women of Childbearing Age in Parakou in 2017

As in other countries of West Africa, Benin has a low rate of MCM utilization. The factors which lead to this low rate of use vary from one country to another. Purpose: The purpose of this work was to determine the factors associated with the use of modern contraceptive method (MCM) by women of childbearing age (WCBA) in Parakou in 2017. Materials and Methods: It was a cross-sectional and descriptive study with an analytical purpose among WCBA selected in households of the municipality of Parakou after a 2-degree cluster survey. Results: The WCBA’s average age was 29 ± 5.6 years old with extremes of 15 and 46 years. The modern contraceptive prevalence was 14.74%. Among WCBA, 57.14% had an average level of knowledge. The media were the main source of information (75.84%). Among them 34.39% never discussed the matter with their spouse; the latter were not in favor of contraception. The educational level, the perception of woman, the spouse’s favorable opinion, the discussion with the spouse, the level of knowledge of MCM and the knowledge of the existence of FP service were significantly associated with the use of MCM with p = 0.0000 after multivariate analysis. Conclusion: The level of MCM use still remains low. Any effort to increase the modern contraceptive prevalence should take into account its associated factors in order to optimize the use of MCM in the municipality of Parakou in 2017.
Coaching Leadership Traits Preferences of University and College Athletes

— This study examined coaching leadership traits as preferred by athletes of universities and colleges of education located in Lagos State, South West Nigeria. Athletes from two universities (n=99) and two colleges of education (n=92) were involved as study sample. The Leadership Trait Preference Questionnaire (LTPQ) was used to measure athletes’ preferences. Mean and Spearman rank order statistics were used to analyze collected data. Results showed that the traits of friendliness and happiness, sense of humour and cheerfulness, and cooperation were most preferred irrespective of type of institution. College of education athletes were found to have higher mean preferences (M=34.54; SD=9.42) of leadership traits than their university counterparts (M=33.64; SD=9.46). A significantly strong relationship (rho=.81;*p<0.05) was found between preferences of university and college of education athletes. It was recommended that coaches as leaders should from time to time exhibit emotive aspects of themselves to inspire athletes to higher performance.
Adrenergic Receptor Polymorphisms Associated with Resting Heart Rate: The HyperGEN Study

The association between polymorphisms in the β1, β2 and α2B adrenergic receptor (ADR) genes (ADRB1, ADRB2 and ADRA2B) and resting heart rate was examined in white and African‐American participants of the HyperGEN Study. All analyses were adjusted for age, sex, body mass index, alcohol use, smoking status and daily exercise within strata of race, hypertension status and beta‐blocker use. The Ser49Gly polymorphism of the β1 ADR was associated with resting heart rate in hypertensive African‐Americans and hypertensive whites taking beta‐blockers, with carriers of the Gly allele having a higher mean resting heart rate by 2.7 and 4.4 beats per minute (bpm), respectively. The Arg389Gly polymorphism of the β1 ADR was associated with lower heart rate in the normotensive African‐American sample. A β1 haplotype (Ser49Gly‐Arg389Gly) was modestly associated with resting heart rate in the hypertensive African‐Americans. The α2B C/A polymorphism was associated with heart rate in hypertensive whites, and both whites and African‐Americans taking beta‐blockers, with carriers of the A allele having a higher mean resting heart rate. In summary, each of the ADR gene polymorphisms was associated with heart rate in at least one stratum studied, but there was no consistent association from which one would infer a large genetic contribution to heart rate.
Using ARCAP time-frequency representations for decision

We address the problem of estimating and classifying multicomponent narrow band signals using ARCAP Time-Frequency Representations (TFRs). ARCAP TFRs are build using firstly, an instantaneous frequency estimator and, secondly, an instantaneous power estimator, and results in a set of points without any time links. The spectral trajectories have then to be extracted, and we apply a Kalman filter. The trajectories parameters (chirps slopes, beginning and ending instants and frequencies…) enable the implementation of a supervised classification procedure. Results are given for mono and multicomponent chirp signals.
THE EFFECT OF BEAUTY PRODUCTS ADS EXPOSURE ON THE WOMEN’S SELF-EVALUATION

This paper examines how ads for beauty products affect the way women self-evaluate. We investigated the effect of exposing beauty products in advertising vs. non-advertising contexts and hedonic beauty versus utility products in consumers through three experiments, two in the laboratory and one in the field. Two of the three studies support the effect of exposure of beauty product ads on women's self-assessment. The results show that when women are exposed to advertisements for beauty products, they self-evaluate worse than when exposed only to images of products. This effect, however, applies only to hedonic products. Hedonic products in ads affect how consumers self-evaluate, suggesting that the advertising context itself evokes different ways of thinking about women in themselves.
Minocycline enhances MPTP toxicity to dopaminergic neurons

Minocycline has been shown previously to have beneficial effects against ischemia in rats as well as neuroprotective properties against excitotoxic damage in vitro, nigral cell loss via 6‐hydroxydopamine, and to prolong the life‐span of transgenic mouse models of Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS). We investigated whether minocycline would protect against toxic effects of 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP), a toxin that selectively destroys nigrostriatal dopaminergic (DA) neurons and produces a clinical state similar to Parkinson's disease (PD) in rodents and primates. We found that although minocycline inhibited microglial activation, it significantly exacerbated MPTP‐induced damage to DA neurons. We present evidence suggesting that this effect may be due to inhibition of DA and 1‐methyl‐4‐phenylpridium (MPP+) uptake into striatal vesicles. © 2003 Wiley‐Liss, Inc.
A prognostic model for soft tissue sarcoma of the extremities and trunk wall based on size, vascular invasion, necrosis, and growth pattern

In soft tissue sarcoma, better distinction of high‐risk and low‐risk patients is needed to individualize treatment and improve survival. Prognostic systems used in clinical practice identify high‐risk patients based on various factors, including age, tumor size and depth, histological type, necrosis, and grade.
Continuing education in opioid prescribing.

prevalence of hypertension in the overweight and obese group (Table 1). When we reanalyzed the data and included statistical adjustment for hypertension rather than systolic blood pressure, the findings remained unchanged. Total (hazard ratio [HR], 2.11; 95% CI, 1.54-2.89), cardiovascular (HR, 1.54; 95% CI, 0.91-2.63), and noncardiovascular (HR, 2.35; 95% CI, 1.57-3.52) mortality adjusted for age, race, sex, education, waist circumference, hypertension, total and highdensity lipoprotein cholesterol, and smoking status were higher in normal-weight vs overweight and obese participants with incident diabetes. An alternative explanation for our findings, as pointed out by Yano and colleagues, is that not accounting for renal function may have resulted in residual confounding because renal impairment is associated with lower body mass index, frailty, and higher mortality. Despite this established association, we were unable to account for renal function in our analysis because measures to represent renal function were not universally available across the cohort studies. We acknowledge this limitation of our epidemiological pooled study design. While we attempted to carry out sensitivity analyses excluding participants who died within the first 2 years of follow-up (an indicator of frailty) and adjusting for covariates associated with renal impairment (eg, blood pressure), residual confounding may persist. The higher than expected incidence of diabetes at a lower body weight among Asians is established. Our primary analysis included the small number (n=50) of Asian participants primarily (99%) from the Multi-Ethnic Study of Atherosclerosis. Only our sensitivity analysis presented in Table 3 excluded Asian participants to investigate whether our results changed, which they did not. We agree that additional research in larger samples of Asians is needed. Dr Jornayvaz cites pertinent information about differential mortality associated with common types of diabetes control medications and differential prescription patterns based on body weight (ie, metformin more commonly prescribed in overweight and obese patients and sulfonylureas more common in normal-weight adults). While it is possible that they may have played a role in our unexpected finding, we demonstrated in a sensitivity analysis in Table 3 that even when we relied on diabetes diagnosis by fasting glucose only (excluding individuals taking diabetes control medications), our findings did not change.
Downstream coarsening in headwater channels

Field data from four mountain drainage basins in western Washington document systematic downstream coarsening of median bed surface grain size (D50) and a subsequent shift to downstream fining at a drainage area of about 10 km2. Analyses of network‐wide patterns of unit stream power derived from both channel surveys and digital elevation models reveal maximum unit stream power that in all four study areas roughly corresponds with both the grain size maxima and an inflection in the drainage area‐slope relation thought to represent the transition from debris flow‐dominated channels to fluvially dominated channels. Our results support the hypothesis that basin‐wide trends in D50 are hydraulically controlled by systematic variations in unit stream power in addition to lag deposits forced by mass‐wasting processes. The similar relations found in our four study areas suggest that the tendency for downstream coarsening may be ubiquitous in headwater reaches of mountain drainage basins where debris flow processes set the channel gradient.
Correlations of Plasma Citrulline Levels With Clinical and Endoscopic Score and Blood Markers According to Small Bowel Involvement in Pediatric Crohn Disease

Objective: Several studies have indicated that plasma citrulline levels reflect the extent of mucosal injury of the small intestine. This study was performed to determine whether plasma citrulline levels correlate with the disease activity in pediatric patients with Crohn disease (CD). Methods: A total of 63 CD and 23 ulcerative colitis (UC) patients were included in this study. Disease severity was assessed by pediatric CD activity index (PCDAI), pediatric UC activity index, simplified endoscopic activity score for CD, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR). The correlations among these variables and plasma citrulline levels were evaluated. We performed subgroup analysis whether correlations between plasma citrulline levels and disease activity depend on small bowel involvement in patients with CD. Results: The plasma citrulline levels correlated negatively with CRP (r = −0.332, P = 0.008), ESR (r = −0.290, P = 0.022), and PCDAI (r = −0.424, P = 0.001) in patients with CD. The plasma citrulline levels were significantly lower in patients with jejunal involvement than in those without (P = 0.027). In subgroup analysis, patients with CD with jejunal involvement showed significantly negative correlations of plasma citrulline levels with CRP (r = −0.628, P = 0.016) and PCDAI (r = −0.632, P = 0.015); however, patients with CD without jejunal involvement revealed no correlations of plasma citrulline levels with CRP and PCDAI. There were no significant correlations between plasma citrulline levels and simplified endoscopic activity score for CD. There were no significant correlations of plasma citrulline levels with CRP, ESR, and pediatric UC activity index in patients with UC. Conclusions: Plasma citrulline levels correlated with disease severity as measured by PCDAI, CRP, and ESR in pediatric patients with CD with jejunal involvement.
Analyzing Change in Nursing Home Information Technology Sophistication: A 2-Year Survey.

Nursing home (NH) health information technology (IT) is becoming more prevalent across the country. Currently, a national sample of NHs is being surveyed for 3 consecutive years to determine trends in NH IT sophistication (e.g., measures of IT capabilities, extent of IT use, IT integration with internal and external stakeholders). IT sophistication is measured in resident care, clinical support, and administrative activities. The current article provides details of the differences in NH IT sophistication reported by administrators completing Year 1 and Year 2 surveys. IT in clinical support (i.e., laboratory, pharmacy, and radiology) had the greatest differences. This difference is expected because these areas typically require external contracts, making it dificult to fit IT with existing workflows, which is important for sustained adoption. [Journal of Gerontological Nursing, 43(1), 17-21. ].