Miracle-dz/UniFAR-FTUs huggingface dataset:
Procoagulant Microparticles: New Insights and Opportunities in Pregnancy Loss?

Summary In recent years, prothrombotic states have been not only associated with an increased risk of venous thrombosis, but also with pregnancy complications. In particular there is good evidence linking antiphospholipid antibody syndrome, which is associated with increased thrombin generation (1), to recurrent miscarriage. The importance of procoagulant changes in the pathophysiology of recurrent miscarriage is emphasised by the fact that treatment with heparin and low dose aspirin will substantially improve the likelihood of a successful pregnancy (2). Essentially, this is the only successful medical intervention in the treatment of miscarriage. There are also data now accumulating that link congenital thrombophilia to pregnancy complications such as miscarriage, pre-eclampsia, intra-uterine growth restriction, abruption and intrauterine death (3, 4). Furthermore, recent data have shown that acquired changes in the coagulation system, such as the acquired activated protein C resistance of pregnancy is also associated with an increased risk of pre-eclampsia (5). These data collectively suggest that procoagulant changes in general, rather than congenital or acquired thrombophilia in particular are associated with the development of pregnancy complications including fetal loss. However, in the majority of cases of fetal loss no cause is found and we cannot easily link these events to a procoagulant problem in the mother. In this issue of the Thrombosis and Haemostasis, Laude et al. (6) report, for the first time, the association between circulating procoagulant microparticles and pregnancy loss so providing a new insight into potential mechanisms.
Methodological recommendations for comparative research on the treatment of chronic wounds.

OBJECTIVE To provide specific recommendations to product developers and clinical researchers on the design of comparative effectiveness studies for the treatment of chronic wounds, specifically those pertaining to arterial and venous-disease related ulcers, diabetic foot ulcers, pressure ulcers and burn wounds. METHOD The recommendations were developed based on a process defined by the Center for Medical Technology Policy (CMTP). After selecting the subject area, semi-structured phone interviews were conducted by one of the authors (SSS) with representatives of payers, manufacturers, clinicians, clinician/researchers and patient advocates. Next, a broad range of stakeholders participated in a meeting convened by CMTP to determine their needs. A technical working group comprising key stakeholders then participated in clarifying recommendations developed by CMTP staff and adding important considerations for their implementation. The resulting draft document was finalised based on public and solicited comment from individual manufacturers; a consortium of product developers and manufacturers; and an alliance of physicians, providers, manufacturers and patient organisations. This article is a summary of the full effectiveness guidance document. RESULTS To address the needs of patients, clinicians, guideline developers, payers and other post-regulatory decision makers, this work makes ten recommendations to guide comparative effectiveness research for chronic wound care. These recommendations fall into four categories: study design, population, comparators and outcomes. CONCLUSION This paper suggests that using the recommendations outlined to conduct comparative effectiveness research on treatments for chronic wound therapies would facilitate trials that provide patients, clinicians, and payers with the information they need to make optimal treatment decisions. These recommendations focus on design changes that would have the largest impact in improving the usability of the results by decision makers and provide specific guidance on the design of prospective studies intended to inform decision making by patients, clinicians and payers. DECLARATION OF INTEREST There were no external sources of funding for these recommendations. The Value Institute and the Center for Medical Technology Policy (CMTP) are both private, non-profit organisations. The authors have no financial, commercial or social conflicts of interest to declare with respect to the article or its content.
Examining Differential Gains from Mass Media and their Implications for Participatory Behavior

The idea of interpersonal discussions among citizens being the “soul of democracy” has been treatedalmost as a truism in recent research on media, interpersonal communication, and democratic citizenship. Without a doubt, there is strong evidence to support the notion that interpersonal discussion of politics is a key antecedent of political participation. This study proposes that the relationships between hard news media use, interpersonal discussion of politics, and participatory behavior are far more complex than previously assumed. Specifically, it is expected that hard news media use has an overall positive main effect on political participation. This main effect, however, cloaks significantly different effects for people who talk to others about politics rather frequently and those who do not. National survey data support the differential gains model for newspaper andtelevision hardnews use. This article explores explanations for this phenomenon and implications for future research and policy.
Human amnion favours tissue repair by inducing the M1‐to‐M2 switch and enhancing M2 macrophage features

Human amniotic mesenchymal cells (hAMTCs) possess interesting immunomodulatory properties, making them attractive candidates for regenerative medicine applications. Recent in vivo reports argue in favour of an important role for macrophages as targets of hAMTC‐mediated suppression of inflammation and the enhancement of tissue repair. However, a comprehensive study of the effects of hAMTCs and their conditioned medium (CM) on human macrophage differentiation and function is unavailable. In the present study we found that hAMTCs and CM induce the differentiation of myeloid cells (U937 and monocytes) towards macrophages. We then investigated their effects on monocytes differentiated toward pro‐inflammatory M1 and anti‐inflammatory M2 macrophages. Monocytes treated under M1 conditions in the presence of hAMTCs or CMs shifted towards M2‐like macrophages, which expressed CD14, CD209, CD23, CD163 and PM‐2 K, possessed higher phagocytic activity and produced higher IL‐10 and lower pro‐inflammatory cytokines. They were also poor T cell stimulators and Th1 inducers, while they were able to increase activated and naïve suppressive Treg subsets. We show that prostaglandins, and not IL‐6, play a role in determining the M2 activation status. Instead, monocytes treated under M2 conditions in the presence of hAMTCs or CM retained M2‐like features, but with an enhanced anti‐inflammatory profile, having a reduced expression of the co‐stimulatory molecule CD80, reduced phagocytosis activity and decreased the secretion of inflammatory chemokines. Importantly, we provide evidence that macrophages re‐educated by CM improve tissue regeneration/repair in wound‐healing models. In conclusion, we identified new cell targets of hAMTCs and their bioactive factors and here provide insight into the beneficial effects observed when these cells are used in therapeutic approaches in vivo. © 2016 The Authors Journal of Tissue Engineering and Regenerative Medicine Published by John Wiley & Sons Ltd.
Agent-based manufacturing and control systems - new agile manufacturing solutions for achieving peak performance

AGENT TECHNOLOGY IN MODERN PRODUCTION SYSTEMS Introduction Agents and Multiagent Systems From Agent Technology to Manufacturing Practice Book Motivations and Purposes References ISSUES IN DESIGNING AGENT-BASED MANUFACTURING SYSTEMS Introduction Agent System Engineering Issues in Designing Agent-Based Manufacturing Systems at PS-Bikes Conclusions References AGENTS FOR PLANNING, SCHEDULING, AND CONTROL Introduction Focusing on Planning, Scheduling, and Control Activities in Manufacturing Planning, Scheduling, and Control in Manufacturing from an Integrated Perspective Basic Concepts in Production Planning Basic Concepts in Production Scheduling Basic Concepts in Production Control Agent-Based Applications in Manufacturing Planning and Scheduling Agent-Based Applications for Scheduling and Control in Manufacturing Planning, Scheduling, and Control In PS-Bikes Conclusions References AGENT-BASED SIMULATION Manuel Gentile, Massimo Paolucci, and Roberto Sacile Introduction Modeling and Simulating in Manufacturing Multiagent-Based Simulation Platforms to Support Multiagent-Based Simulation Development An Application of MABS in PS-Bikes Conclusions References AGENT SYSTEM IMPLEMENTATION Massimo Cossentino and Luca Sabatucci Introduction A Case Study: Designing the PS-Bikes System Designing the Solution with PASSI Agent Implementation References PAST SUCCESSES Introduction Two Outstanding Supply Chain-Oriented MAS Applications in Manufacturing Successful MAS Applications in Manufacturing Planning and Scheduling Successful MAS Applications in Manufacturing Scheduling and Control Practical Working Industrial Applications Conclusions References FUTURE CHALLENGES Introduction Next Generation e-Manufacturing Solutions What Must Be Refined in Agent-Based Manufacturing What Has Yet to Be Done in Agent-Based Manufacturing PS-Bikes and Its Challenging "Agentification" Process to Achieve Agility Conclusions References
Antecedents and outcomes of career development in Jordanian public sector

Defining and maintaining a sustainable career development process call for theorizing and testing the antecedents and outcomes of career development practices across different contexts. Nowadays, human resources managers are highly in need of information to design more effective programs and policies to retain valuable employees by providing career activities that make them feel secure and valuable which in turn reduce their intention to leave and improve performance. Accordingly, this study aims to examine empirically the antecedents (career planning and career management) and outcomes (organizational commitment, job creativity, and job turnover) of career development in the Jordanian public sector. A self-administered survey involving 531 Jordanian employees in public sector organizations was used for the investigation. Results supported the research model. The analysis showed that both antecedent variables, career planning and career management, have a positive significant influence on career development with approximate explanation values of variance 20 percent and 23 percent respectively. The findings also revealed significant positive influence of career development on organizational commitment and job creativity but a negative influence on job turnover. The findings also showed that about 40% of the sample did not participate in any career training program. These findings would be useful to human resources managers during the selection and promotion processes of employees, as well as supervisors to manage the effect of work related outcomes, mainly commitment and creativity, to reduce turnover rates and lengthen the career path of employees.
Engaging preservice primary and preprimary school teachers in digital storytelling for the teaching and learning of mathematics

A significant criticism made of preservice teacher education is that it fails to prepare teachers in such a way that they would feel confident in the use of information and communication technology ( ICT) in teaching, despite the assumed digital literacy of student-teachers and the children they will eventually teach. New technologies have enabled multimodal design and digital storytelling in meaning-making and communication and are now often instrumental and influential in shaping students' social practices and identities. The purpose of this study was to explore an integrative approach in applying ICT in learning with specific reference to the formation of mathematics teaching capability in preservice teachers. It takes into consideration student-teachers' lived experiences when introducing ICT supported learning into their classrooms as well as their exposure to related university courses such as educational technology, special didactics of mathematics and mathematics. This paper describes the instructional design framework and assessment criteria for mathematical problem solving and digital storytelling introduced to an ICT course for student-teachers. Based on the analysis of pre- and posttesting of the subjects' capabilities and reports of their perceptions, it is suggested that preservice teachers can efficiently develop their content knowledge in mathematics problem solving and that an integrative approach such as that described here may facilitate both mathematical problem-solving competences and pedagogical competences for applying digital storytelling in solving mathematical problems. The cohort of preservice teachers had no prior experiences of digital storytelling or multimodal design and perceived them as new practices. Their conceptions changed during the course from the passive recipients to active producers of media content. They demonstrated reflection relative to learning-by-design and representation modelling. They perceived digital storytelling as a strategy and means for empowering the 'student-voice' and the active construction of knowledge. The findings of the study contribute to preservice teacher education indicating that an integrated approach of instruction that deploys digital storytelling and multimodal design can help facilitate preservice teachers' pedagogical competencies and mathematical content knowledge. [ABSTRACT FROM AUTHOR]
The incidentally discovered adrenal mass.

2. Herrera MF, Grant CS, van Heerden JA, Sheedy PF, Ilstrup DM. Incidentally discovered adrenal tumors: an institutional perspective. Surgery 1991; 110(6):10141021. Review/OtherDx 342 patients To investigate the effect of size of incidental adrenal masses in patients without known malignancy. Studies to evaluate biochemical hyperfunction were performed in 172 patients (50%), 2 of whom were found to have cortisol-producing tumors and 5 pheochromocytomas. Histologic proof of diagnosis was obtained in 55 patients at the time of adrenalectomy. Malignancy was discovered in five patients (four primary and one metastatic), the smallest malignant tumor measuring 5 cm. In the 287 patients without histologic diagnoses, a minimum of 1 year of clinical follow-up was obtained in 251 (88%), including repeat CT scan in 156 (54%). None of these patients had clinical or biochemical adrenal abnormalitie. Authors suggest biochemical screening and surgical excision for all lesions >4 cm. Follow-up CT should be performed at 3 months in lesions <4 cm. 4
Mindfulness Predicts Relapse/Recurrence in Major Depressive Disorder After Mindfulness-Based Cognitive Therapy

Empirical evidence for the effectiveness of mindfulness-based cognitive therapy (MBCT) is encouraging. However, data concerning the role of mindfulness in its relapse preventive effect are lacking. In our study, 25 formerly depressed patients received MBCT. Mindfulness was assessed before and immediately after MBCT using the Mindful Attention and Awareness Scale. Mindfulness significantly increased during MBCT, and posttreatment levels of mindfulness predicted the risk of relapse/recurrence to major depressive disorder in the 12-month follow-up period. Mindfulness predicted the risk of relapse/recurrence after controlling for numbers of previous episodes and residual depressive symptoms. The results provide preliminary evidence for the notion that mindfulness is an important factor in relapse prevention in major depression.
The building-up and improvement of human resource mixed employment model

Our study is part of an attempt to build up a mixed employment research model addressing the interaction between nonstandard employees and standard employees in the mixed employment work environment. Our initial research model is built up through a two-way analysis of the interaction between the standard and nonstandard employees mainly from three aspects which are job satisfaction, organizational commitment and organizational fairness. The hypotheses of the initial model regard employee identity as moderating variable, leadership style and perceived job importance as mediating variables. Based on the empirical study of 264 effective samples, results indicate that one of the hypotheses of the initial model is invalid. Thus, a newly amended mixed employment model is being developed.
Robust maneuver control and vibration suppression of flexible spacecraft with unknown disturbance and uncertainty

In order to meet the requirement of rapid attitude maneuver control and vibration suppression of flexible spacecraft with disturbance and uncertainty, this paper presents a robust control scheme based on path planning and adaptive backstepping control. Firstly, a novel path planning scheme is proposed based on quintic polynomial transition. The continuous and smooth maneuver path is designed to solve the conflict between swiftness and overshoot in traditional path planning methods as well as to suppress the vibration of flexible appendages. By planning the desired angular acceleration of the maneuver path, appendages' vibration induced by attitude maneuver is decreased effectively. Furthermore, an adaptive robust controller is derived using the backstepping technique, including an adaptation mechanism to estimate the unknown disturbances and uncertainties so that the prior knowledge of the upper bounds on the total disturbance is not necessary for the controller design. Finally, the illustrative simulation results demonstrate the effectiveness and robustness of the proposed control scheme.
Current status and future prospects of the Global Lymphatic Filariasis Programme

Lymphatic filariasis is recognized as one of the world's most disabling diseases. Adult lymphatic filarial nematodes live for several years; they infest the lymphatic and blood systems, and are transmitted via mosquito vectors. Acute and chronic disease can develop, manifesting as acute inflammation, hydrocoele, lymphoedema and elephantiasis. The development of a global programme for the elimination of lymphatic filariasis (focusing on disease caused by Wuchereria bancrofti) followed a resolution by the World Health Assembly in 1997 that endemic countries should develop programmes to eliminate lymphatic filariasis as a public health problem. This developed from an earlier recommendation by the International Task Force for Disease Eradication in 1993 that lymphatic filariasis was one of six diseases that could, in theory, be eradicated. Herein we review the current status and future prospects of the Global Lymphatic Filariasis Programme, which was launched in 2000.
Ultrasound guided percutaneous drainage of abdominal abscesses.

OBJECTIVE To see yield of ultrasound guided percutaneous drainage of abdominal abscesses. SETTING Department of General Surgery Unit I, Lahore General Hospital and North Surgical Unit, Mayo Hospital, Lahore. DESIGN A prospective case-controlled study. SUBJECTS Patients with spontaneous or post operative abdominal abscesses. RESULTS Overall success rate was 96.2%, major complications 11.5%, minor complications 26.9% and mortality 3.8%. In simple abscesses (20 patients), the success rate was 100% and in complex abscesses (six patients) 83.4%, with respective mortality 0.0% and 16.6%. Mean hospital stay was 10.7 days (range 3-25). CONCLUSION Ultrasound guided percutaneous drainage of abdominal abscesses is an effective and safe method, suited particularly for simple abscesses.
Who decides when to start preventive treatment? A questionnaire survey to compare the views of different population subgroups

Lipid lowering drugs lower the risk of ischaemic cardiovascular events. The absolute benefit is highest in people at greatest risk of having an event in the near future, but adverse effects and costs are similar whatever the baseline risk. The decision to treat entails balancing expected benefits with expected harms,1 but is essentially a value judgement. Treatment preferences may vary systematically between groups of people either because they have different levels of baseline risk, or because they have different values and priorities. Current UK guidelines recommend treatment for those whose 10 year risk of coronary heart disease is at least 30%. 2,3 Assuming a relative risk reduction of one third this is an absolute benefit of about 10% over 10 years (or 5% over five years). Very little is known about the level of coronary risk at which either doctors or patients want treatment.4 One small study suggested that patients and nurses would choose higher risk thresholds (larger absolute benefits) than doctors.5 The policy to treat a risk of 30% over …
Rythmes et appartenances culturelles : étude acoustique des échanges vocaux entre mères et bébés autochtones et migrants

Cette etude s'appuie sur des methodes d'analyse acoustique pour eclairer le lien entre la qualite de la negociation dynamique au cours de l'interaction mere-bebe et le sentiment d'identite de la mere. Nous montrons que l'expressivite et la contingence de l'interaction vocale mere-bebe sont particulierement affectees lorsqu'une mere qui a emigre n'a plus la meme perception de soi ni la meme confiance en soi qu'avant. Soixante enregistrements d'interactions spontanees mere-bebe ont ete effectues en Inde, en France et aux Etats-Unis avec des bebes âges entre 2 et 6 mois. Leur analyse a revele une hierarchie rythmique universelle : toutes les dyades mere-bebe s'appuient sur une pulsation et sur des sensibilites musicales innees pour exprimer conjointement des narrations dans le temps. D'importantes differences culturelles ont egalement ete observees entre les dyades francaises, indiennes et americaines concernant des regles culturelles specifiques de la negociation dans le dialogue. Ces differences nous ont amenee a proposer que des l'âge de 2 mois le bebe commence a incorporer les rythmes et styles expressifs qui constituent sa "culture primaire". La comparaison entre 30 dyades migrantes et 30 dyades autochtones a montre que les migrantes sont, de maniere generale, moins expressives et moins harmonieuses, ou moins "musicales", dans la coordination rythmique de leurs interactions. Des etudes de cas et des analyses qualitatives eclairent les resultats quantitatifs. L'effet de la migration n'est cependant pas uniforme et un sous-groupe de meres migrantes presentant des facteurs de risque a ete identifie. L'analyse acoustique eclaire, au niveau micro, la maniere dont le sens est partage dans un espace intersubjectif entre la mere et le bebe grâce a un equilibre subtil entre regularite rythmique et variation expressive. Nous explorons la facon dont, comme dans la musique de jazz, le succes du partage intersubjectif significatif depend des qualites spontanees dynamiques d'expressions negociees. Ainsi, le processus de l'appartenance depend peut-etre d'une negociation musicale sensible au cours d'interactions vives. Ce travail souligne l'importance de la prise en charge precoce et de la prevention parmi les populations migrantes et propose d'employer la "musicalite" comme critere diagnostique.