Miracle-dz/UniFAR-FTUs huggingface dataset:
antiplatelet protein, a saliva protein from a malaria vector mosquito Inhibition of collagen-induced platelet aggregation by anopheline

http://bloodjournal.hematologylibrary. org/cgi/content/full/111/4/2007 Updated information and services can be found at: (2392 articles) Hemostasis, Thrombosis, and Vascular Biology  collections: Blood Articles on similar topics may be found in the following http://bloodjournal.hematologylibrary. org/misc/rights.dtl#repub_requests Information about reproducing this article in parts or in its entirety may be found online at: http://bloodjournal.hematologylibrary. org/misc/rights.dtl#reprints Information about ordering reprints may be found online at: http://bloodjournal.hematologylibrary. org/subscriptions/index.dtl Information about subscriptions and ASH membership may be found online at:
Impact of Cross-Listing on Local Stock Returns: Case of Russian Adrs

The paper examines the impact of American Depositary Receipt (ADR) listings on the return of the underlying Russian stocks. The contribution of this paper is twofold. First, it looks at a new sample of ADRs issued by Russian companies. Second, the technique used to estimate the market model is different from the previous studies. The returns are modeled to follow GARCH process, as opposed to the regular OLS procedure, which assumes homoscedasticity in residual returns. Average abnormal returns and cumulative average abnormal returns are calculated for the [-25, +25] event window, with the ADR listing date being the event date. The results indicate a significant negative abnormal local market return on an ADR listing day. The return volatilities after the listing are compared to those before the listing. Eleven out of sixteen companies experienced increased volatility of local returns after the cross-listing.
Low-Grade Inflammation in Relation to Preceding Factors and the Course of the Metabolic Syndrome

The metabolic syndrome (MetS), a cluster of risk factors for cardiovascular disease and type 2 diabetes, is associated with low-grade inflammation, a state in which several cytokines are secreted from adipose tissue. Decreased adiponectin and increased interleukin-1 receptor antagonist (IL-1Ra) levels have been observed with the MetS. Elevated levels of Creactive protein (CRP), a general inflammatory marker, often appear with metabolic diseases. There is existing evidence of gender differences in relation to the MetS as a cardiovascular risk or inflammatory markers associated with metabolic diseases. The role of low-grade inflammation in the development of these diseases is not well-known. This study was aimed at obtaining gender-specific information about the association of adiponectin and low-grade inflammation, measured by high sensitivityCRP (hs-CRP) and IL-1Ra, with the factors that often precede the MetS (e.g. weight gain, elevated blood pressure and smoking), and with the course of the MetS. The study population consisted of five age groups of inhabitants in the town of Pieksämäki (n=1294), who were invited for a health check-up in 1997-1998 and again in 2003-2004. Of the invited subjects, 923 (71.3%, 411 men and 512 women) participated in the first check-up and 681 subjects of them in the second check-up. The results indicate that decreased adiponectin and increased hs-CRPand IL-1Ra levels were associated with a relative change in body mass index from the age of 20 years to middle age in women, but not in men. The proportion of women with lower socioeconomical status increased with relative weight gain; in men there was no association. Decreased adiponectin levels in females and increased hs-CRP levels in males were associated with smoking. Women with elevated blood pressure and the MetS had significantly higher levels of hs-CRP and IL-1Ra compared to men. The risk for the MetS was threefold in hypertensive women with the lowest tertile of adiponectin; no association was seen in men. Decreased baseline adiponectin and increased baseline IL-1Ra levels were associated with both the appearance and the persistence of the MetS; increased baseline hsCRP levels were linked with the persistence of the MetS. In conclusion, from the aspect of low-grade inflammation, greater relative weight gain is more harmful to women than to men. Women, who smoke may be more prone to development of inflammatory state due to decreased adiponectin levels compared to men. Decreased adiponectin level and increased low-grade inflammation may refer to an unfavorable course of the MetS in both genders. National Library of Medicine Classification: WG 340, WK 820, WD 200 Medical Subject Headings: Metabolic Syndrome X; Adiponectin; Smoking; C-Reactive Protein; Hypertension; Interleukin 1 Receptor Antagonist Protein; Sex Factors; Body mass index
The Effect of a Suggested Program Based on Interactional Metadiscourse Markers on Developing EFL Majors’ Reading Comprehension and the Reader-friendliness of Their Writing

This study attempted to investigate the effect of using a suggested program of interactional metadiscourse markers on EFL majors’ reading comprehension and on their reader-friendly writing. The study used a pre-test/post-test experimental and control group design. An experimental group and a control group were exposed to pre-post means of getting data (a pre-post reading comprehension test and pre-post writing test). Thirty four EFL majors at the College of Education and Arts, Northern Borders University, participated in this study. A 10-week program of interactional metadiscourse markers was developed and given to experimental group students. Results revealed a significant improvement in the reading comprehension of the experimental group students and in their reader-friendly writing. Based on these findings, it was recommended that explicit teaching of metadiscourse markers should be integrated into EFL majors’ curricula.
The Impact of Menopause on Diabetic Retinopathy

Background: The disease due to the disturbances in glucose, lipid and protein metabolisms which is the most prevalent disease of our times is known as diabetes. This multifactorial disease is more common in females of post menopause period because of different risk factors like higher age and body mass index (BMI). Participants and Methods: The study was conducted on 1315 patients with type II diabetes referred to the Diabetes Clinic of Imam Khomeini hospital, in Tehran, Iran, in 2014. Sampling 534female patients aging from 30 up to 70, and with clinical history of 1up to 20 years of type II diabetes, and also with urinary albumin excretion of 30 up to 300mg per 24 hours, was carried out and then divided into pre-menopause and menopause groups. With controlled blood pressure, all these patients were under retinopathy assessment by an ophthalmologist. Lipid profile, BMI and HbA1c were also were also measured and the results using SPSS (version 19) were then analyzed. Results: According to the evidences, micro-albuminuria was a common complication of type II diabetes, and there was a direct interrelation between micro-albuminuria and retinopathy. The study demonstrated micro-albuminuria increased in the menopause group, where menopause alone had no effect on retinopathy. In fact, the effective factors in association with microalbuminuria and retinopathy in the menopause group were urinary albumin excretion (UAE), HbA1c, BMI and age and in the pre-menopause group were HbA1c, HDL, TG and age. Finally, since micro-albuminuria is a risk factor for retinopathy, and also micro-albuminuria is influenced by hormones, thus, hormone therapy seems to be helpful in controlling micro-albuminuria and thereby reducing retinopathy. Conclusion: It was concluded that retinopathy did not increase with menopause. In fact, glycemic factors seemed to have the maximum impact on retinopathy. In order to reduce microalbuminuria and thereby retinopathy, it is therefore suggested to have a greater control over hyperglycemia.
Reading performance, learning strategies, gender and school language as related issues ? PISA 2009 findings in Finland and Estonia.

Reading is considered an important skill not only for academic success, but also for active participation in society. International student literacy assessments report gender differences in reading performance in favour of girls. These reports also show that students from schools with a minority or majority language tend to perform differently: in PISA 2009 in well-performing Finland, the Swedish-speaking schools performed at a lower level compared to the Finnish-speaking schools; in Estonia, the Estonian-speaking schools outperformed the Russian-speaking schools, despite the tests having been translated into each language. How students learn is closely related to their results. In literacy, the more advanced thinking and learning skills known as metacognition enhance the results. Metacognitive awareness can be developed through instruction in the classroom, and this has also resulted in significant improvements for students with rather low learning abilities. As it is teachers? and schools? opportunity to help their students by teaching these skills, their awareness of useful strategies could presumably be dependent on the school. So far only the PISA 2009 study has included student awareness of different learning strategies; therefore, the data here enable us to analyse how learning strategies relate to reading, gender or school language. In the current paper, the issues of reading proficiency, learning strategies, gender and school language are considered jointly. Alongside the theoretical background, results from several analyses of PISA 2009 are discussed to show how student awareness and choice of different learning strategies could explain the variation in reading results in boys and girls at student and school levels, and predict their reading test results. The two-level modelling analysis was used as a research method, since it allows us to draw reasonable statistical inferences for regression-type analyses under a hierarchical data structure, and where the factor of individuals being influenced by the group they belong to is explicitly taken into account.Acknowledgements:This research was supported by European Social Fund's Doctoral Studies and Internationalization Programme DoRa, which is carried out by Foundation Archimedes, project 1.2. 0401.09-0070.
Virtual population analysis of two snapper species, Lutjanus analis and Lutjanus chrysurus, caught off Pernambuco State, north-eastern Brazil

We applied steady-state Virtual Population Analysis - VPA to two stocks of snappers (Lutjanus analis and L. chrysurus) exploited by artisanal hand-line fleets along the Pernambuco State coast (North-eastern Brazil). We show that even short-data series (1 year of sampling) can produce a useful diagnosis of fisheries resources. Both stocks are slightly overexploited by the hand-line fishery and a higher yield-per-recruit would be obtained by a reduction of effort of 16% for L. analis and 43% for L. chrysurus. Given the impracticability of managing the two stocks separately, we propose a 25% decrease of fishing effort for the hand-line fleet. By incorporating the results of VPA into a simulation framework, we can develop a comparison of the likely result of different policy options (effort regulation) based on 3 simple indicators (Spawning stock biomass-per-recruit, biomass-perrecruit and yield-per-recruit). We compare the results of effort reduction with those of effort increase (25%) through simulation analysis. Allowing for the difficulty of testing assumptions introduced in our model (steady-state, Beverton and Holt recruitment model) and using standard fisheries analysis techniques, we show that useful fisheries advice can be produced even in a context of limited data. Providing advice to developing countries coastal fisheries is an urgent issue, given the high dependence of local communities on coastal living resources and the increasing fishing effort applied by a growing population.
Ground-based remote sensing of tropospheric water vapour isotopologues within the project MUSICA

Abstract. Within the project MUSICA (MUlti-platform remote Sensing of Isotopologues for investigating the Cycle of Atmospheric water), long-term tropospheric water vapour isotopologue data records are provided for ten globally distributed ground-based mid-infrared remote sensing stations of the NDACC (Network for the Detection of Atmospheric Composition Change). We present a new method allowing for an extensive and straightforward characterisation of the complex nature of such isotopologue remote sensing datasets. We demonstrate that the MUSICA humidity profiles are representative for most of the troposphere with a vertical resolution ranging from about 2 km (in the lower troposphere) to 8 km (in the upper troposphere) and with an estimated precision of better than 10%. We find that the sensitivity with respect to the isotopologue composition is limited to the lower and middle troposphere, whereby we estimate a precision of about 30‰ for the ratio between the two isotopologues HD16O and H216O. The measurement noise, the applied atmospheric temperature profiles, the uncertainty in the spectral baseline, and the cross-dependence on humidity are the leading error sources. We introduce an a posteriori correction method of the cross-dependence on humidity, and we recommend applying it to isotopologue ratio remote sensing datasets in general. In addition, we present mid-infrared CO2 retrievals and use them for demonstrating the MUSICA network-wide data consistency. In order to indicate the potential of long-term isotopologue remote sensing data if provided with a well-documented quality, we present a climatology and compare it to simulations of an isotope incorporated AGCM (Atmospheric General Circulation Model). We identify differences in the multi-year mean and seasonal cycles that significantly exceed the estimated errors, thereby indicating deficits in the modeled atmospheric water cycle.
Exotic States of High Density Matter Driven by Intense XUV/X-Ray Free Electron Lasers

XUV and X-ray Free Electron Lasers (XFEL’s) have provided the high energy density physics community with outstanding tools to investigate and to create matter under extreme conditions never achieved in laboratories so far. The key parameters of existing and planed XFEL installations [LCLS 2011, XFEL 2011, SACLA XFEL 2011] are micro focusing (to achieve intensities in access to 1016 W/cm2), short pulse lengths (10-100 fs), tunable photon energy (1-20 keV), small bandwidth and high repetition frequency (some 10 Hz, allowing to accumulate thousands of shots to improve signal to noise ratios).
Influence of feeding on the development of bacterial gill disease in rainbow trout Oncorhynchus mykiss.

Three trials were conducted to determine if feeding influenced the development of bacterial gill disease (BGD) in fingerling rainbow trout Oncorhynchus mykiss following bath exposure to Flavobacterium branchiophilum (LAB 4a). In each trial (Trial 1. n = 70 X 3; Trial 2, n = 140 X 3 ; Trial 3, n = 250 X 3), the comparison groups (fed, unfed, negative controls) were held in similar conditions and (where applicable) fed prior to exposure to the pathogen. Severe clinical signs and high rates of mortality developed within 24 h in fish which were provided feed following the bath exposure. Cumulative mortalities ranged from 43 to 63% by 12 d post-exposure Unfed fish demonstrated only mild and transient clinical signs of BGD, and cumulative mortalities of 0 to 2 % 12 d post-exposure. In one trial, resumption of feeding 6 d post-exposure resulted in 26% cumulative mortality within 7 d. Estimation of the quantity of F branchiophilum antigen by enzyme-linked immunosorbent assay (ELISA) indicated that feeding facilitated colonization of the gill. The evaluation of water quality and direct observations suggest that the influence of feeding on BGD is linked to the consumption of feed by the fish, rather than to environmental changes arising from feeding. Alterations in the unstirred layer on the gill, secondary to feed consumption and waste excretion, may aid bacterial colonization.
Constraints on core‐mantle boundary topography from normal mode splitting

The frequencies of Earth's normal modes are split by rotation, ellipticity, and internal structure of the Earth. Thus, models of mantle heterogeneity and discontinuity topography generate splitting that may be tested against observations. We insert maps of core‐mantle boundary (CMB) topography, which are derived via either a purely seismic or a joint tomographic/geodynamic inversion of body waves data, on top of tomographic model S20RTS. We then calculate synthetic splitting functions for normal modes that have been shown to be sensitive to CMB topography and compare these to observed normal mode splitting data. The CMB topography maps obtained via geodynamically constrained tomography fit normal mode data better than purely seismic maps, in particular when the geodynamic constraint also accounts for the presence of post‐perovskite in the D″ region. We test the significance of the reduction in misfit using the concept of observability which suggests that normal modes are able to observe the difference between the different CMB topography maps. In addition, we find that the statistical significance, assessed by checking what fraction of 1000 randomly generated CMB models achieve a comparatively good fit as the desired model, is higher than 92% for degree 2 and 98% for all degrees. In summary, we have identified a model of CMB topography that fits body wave data and improves, at least to some extent, the fit to normal mode data, and is coherent with the large‐scale pattern of deep mantle heterogeneity expected on the basis of convection modeling.
Tipología de productores de maíz en los municipios de Villaflores y La Trinitaria, Chiapas

Dada la relevancia del maíz a nivel nacional, la tipificación de los productores en los municipios de mayor importancia sobre la participación del sistema productivo del maíz del estado de Chiapas, es trascendental para el diseño especifico de políticas públicas que propicie el incremento de la producción y el logro del desarrollo agrícola. Debido a la complejidad de la agricultura en el país por su diversificación en cuanto al proceso productivo, comportamiento y tendencias. Lo que implica vislumbrar a los actores en el escenario rural, en términos de su articulación en el espacio territorial, la disponibilidad de tecnologías y apoyos gubernamentales, así como sus alcances y limitaciones. El objetivo de esta investigación, fue tipificar a los productores de maíz en los municipios de Villaflores y La Trinitaria, mediante la determinación de las condiciones de producción, para establecer los factores que fortalecen a las unidades productivas en el año 2018. Se aplicó el muestreo estratificado afijación proporcional y el análisis multivariado por conglomerados, mediante los métodos jerárquico y de agrupamiento wards. Los resultados han identificado tres tipos de productores para cada uno de los municipios, donde las variables que marcaron las diferencias entre tipos fueron: la edad, escolaridad y experiencia del productor, superficie agrícola, destino y costos de producción, tipo de semilla, rendimientos, entre otras. Se concluye, que la producción de maíz sigue siendo un factor y eje central para los agricultores de la región.
Detecting Linguistic Traces of Depression in Topic-Restricted Text: Attending to Self-Stigmatized Depression with NLP

Natural language processing researchers have proven the ability of machine learning approaches to detect depression-related cues from language; however, to date, these efforts have primarily assumed it was acceptable to leave depression-related texts in the data. Our concerns with this are twofold: first, that the models may be overfitting on depression-related signals, which may not be present in all depressed users (only those who talk about depression on social media); and second, that these models would under-perform for users who are sensitive to the public stigma of depression. This study demonstrates the validity to those concerns. We construct a novel corpus of texts from 12,106 Reddit users and perform lexical and predictive analyses under two conditions: one where all text produced by the users is included and one where the depression data is withheld. We find significant differences in the language used by depressed users under the two conditions as well as a difference in the ability of machine learning algorithms to correctly detect depression. However, despite the lexical differences and reduced classification performance–each of which suggests that users may be able to fool algorithms by avoiding direct discussion of depression–a still respectable overall performance suggests lexical models are reasonably robust and well suited for a role in a diagnostic or monitoring capacity.
Periodic arrays of gyrotactic plumes in bioconvection

Using the continuum model of Pedley et al. [J. Fluid Mech. 195, 223 (1988)] for bioconvection in a suspension of swimming, gyrotactic micro-organisms, the existence and stability of periodic arrays of two-dimensional plumes in deep chambers are investigated. The system is governed by the Navier–Stokes equations for an incompressible fluid coupled with a micro-organism conservation equation. These equations are solved numerically using a conservative finite-difference scheme. In sufficiently deep chambers, the plumes are sometimes unstable to varicose or meandering modes. A linear stability analysis for an infinitely deep plume predicts the growth rates of these instabilities and agrees well with the numerical results.
Nearly free curves and arrangements: a vector bundle point of view

Abstract Over the past forty years many papers have studied logarithmic sheaves associated to reduced divisors, in particular logarithmic bundles associated to plane curves. An interesting family of these curves are the so-called free ones for which the associated logarithmic sheaf is the direct sum of two line bundles. Terao conjectured thirty years ago that when a curve is a finite set of distinct lines (i.e. a line arrangement) its freeness depends solely on its combinatorics, but this has only been proved for sets of up to 12 lines. In looking for a counter-example to Terao’s conjecture, the nearly free curves introduced by Dimca and Sticlaru arise naturally. We prove here that the logarithmic bundle associated to a nearly free curve possesses a minimal non-zero section that vanishes on one single point, P say, called the jumping point, and that this characterises the bundle. We then give a precise description of the behaviour of P. Based on detailed examples we then show that the position of P relative to its corresponding nearly free arrangement of lines may or may not be a combinatorial invariant, depending on the chosen combinatorics.
Corrigendum Familial Resemblance for Serum Metabolite Concentrations — Corrigendum

1 Department of Biological Psychology, Faculty of Psychology and Education, VU University Amsterdam, Amsterdam, The Netherlands 2 The EMGO Institute for Health and Care Research, Amsterdam, The Netherlands 3 Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands 4 Netherlands Consortium for Healthy Ageing, Leiden University Medical Center, Leiden, The Netherlands 5 Department of Human Genetics, Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands 6 Institute of Experimental Genetics, Genome Analysis Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany 7 Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands