Miracle-dz/UniFAR-FTUs huggingface dataset:
Safety and Immunogenicity of Malaria Vectored Vaccines Given with Routine Expanded Program on Immunization Vaccines in Gambian Infants and Neonates: A Randomized Controlled Trial

Background Heterologous prime-boost vaccination with chimpanzee adenovirus 63 (ChAd63) and modified vaccinia virus Ankara (MVA) encoding multiple epitope string thrombospondin-related adhesion protein (ME-TRAP) has shown acceptable safety and promising immunogenicity in African adult and pediatric populations. If licensed, this vaccine could be given to infants receiving routine childhood immunizations. We therefore evaluated responses to ChAd63 MVA ME-TRAP when co-administered with routine Expanded Program on Immunization (EPI) vaccines. Methods We enrolled 65 Gambian infants and neonates, aged 16, 8, or 1 week at first vaccination and randomized them to receive either ME-TRAP and EPI vaccines or EPI vaccines only. Safety was assessed by the description of vaccine-related adverse events (AEs). Immunogenicity was evaluated using IFNγ enzyme-linked immunospot, whole-blood flow cytometry, and anti-TRAP IgG ELISA. Serology was performed to confirm all infants achieved protective titers to EPI vaccines. Results The vaccines were well tolerated in all age groups with no vaccine-related serious AEs. High-level TRAP-specific IgG and T cell responses were generated after boosting with MVA. CD8+ T cell responses, previously found to correlate with protection, were induced in all groups. Antibody responses to EPI vaccines were not altered significantly. Conclusion Malaria vectored prime-boost vaccines co-administered with routine childhood immunizations were well tolerated. Potent humoral and cellular immunity induced by ChAd63 MVA ME-TRAP did not reduce the immunogenicity of co-administered EPI vaccines, supporting further evaluation of this regimen in infant populations. Clinical Trial Registration The clinical trial was registered on http://Clinicaltrials.gov (NCT02083887) and the Pan-African Clinical Trials Registry (PACTR201402000749217).
Diabetic Ketoacidosis-Prospective Study of Clinical Profile and Outcome in a Tertiary Care Hospital

Diabetic-Ketoacidosis (DKA) is a life threatening complication of diabetes mellitus [DM]. It classically occurs in young patient with Type 1DM However it occurs in patients with Type 2 DM and In India. Its incidence is increasing. This study was undertaken to analyse the clinical profile and its outcome of DKA mainly in adults in a tertiary care hospital. This study was under taken in Gorakhpur on 52 cases from January 2014 to December 2015. Diagnosis [10, 11] was made by the presence of hyperglycemia (Blood sugar >250 mg), acidosis (Arterial pH≤7.3) serum carbonate (≤15mEq) and ketonemia. All relevant investigations were performed and patients were treated with the aim to achieve ketone free condition and euglycemia. Fifty two cases (61.2%) out of 85 cases who had fulfilled the DKA diagnostic criteria [10, 11] constituted the clinical material whose age varies from 15 to 75 year(42.5±8.3 year) with male and female ratio of 1:1.08, Ten patient (17.0%) were of Type1DM of whom 3 (5.78) were below 20 years of age. Most of the female were from 4(8 out of 12 cases 66.0%) and 5 (8 out of 14 cases 57.2%) decade of life. 26 cases(50%) had infection as precipitating factor. The main infection was lobar pneumonia [19.2%] pulmonary tuberculosis (15.5%) and urinary tract infection (9.6%). In Type 1DM cases the main cause of DKA was irregular and discontinuation of insulin therapy otherwise in Type 2 DM cases the irregular treatment, lack of diet control and exercise. The main presenting features were dehydration [76.9%] nausea vomiting [59.6%] and hypotension [42.3%]. Characteristic Kusmauli breathing with sweet odor (17.2%). Poor compliance was main feature for the severity of DKA. The average length of hospital stay was longer in Type1 DM [9 days] Mean fluid requirement on first day was 3.5 liter and insulin 112 IV for clearing ketonurea and acidosis. The overall mortality was 10.3%. Diabetic ketoacidosis is a fatal acute metabolic complication of diabetes mellitus with heterogeneous clinical presentation Poor compliance was associated with severity of DKA and infection precipitate the DKA easily The timely early diagnosis and treatment can avoid morbidity and mortality.
Conspiracy culture : from Kennedy Assassination to the X-files

Preface Introduction: Conspiracy/Theory 1.Conpiracy/Culture 2.Plotting the Kennedy Assassination 3.The Problem with No Name: Feminism and the Figuration of Conspiracy 4.Fear of a Black Planet: "Black Paranoia" and the Aesthetics of Conspiracy 5.Body Panic 6.Everything Is Connected Afterword
Glycosyltransferase cascades made fit for chemical production: Integrated biocatalytic process for the natural polyphenol C‐glucoside nothofagin

Glycosyltransferase cascades are promising tools of biocatalysis for natural product glycosylation, but their suitability for actual production remains to be shown. Here, we demonstrate at a scale of 100 g isolated product the integrated biocatalytic production of nothofagin, the natural 3′‐C‐β‐D‐glucoside of the polyphenol phloretin. A parallel reaction cascade involving coupled C‐glucosyltransferase and sucrose synthase was optimized for the one‐pot glucosylation of phloretin from sucrose via an UDP/UDP‐glucose shuttle. Inclusion complexation with the highly water soluble 2‐hydroxypropyl‐β‐cyclodextrin pushed the phloretin solubility to its upper practical limit (∼120 mM) and so removed the main bottleneck on an efficient synthesis of nothofagin. The biotransformation thus intensified had excellent performance metrics of 97% yield and ∼50 gproduct/L at a space‐time yield of 3 g/L/hr. The UDP‐glucose was regenerated up to ∼220 times. A scalable downstream process for efficient recovery of nothofagin (≥95% purity; ≥65% yield) was developed. A tailored anion‐exchange chromatography at pH 8.5 was used for capture and initial purification of the product. Recycling of the 2‐hydroxypropyl‐β‐cyclodextrin would also be possible at this step. Product precipitation at a lowered pH of 6.0 and re‐dissolution in acetone effectively replaced desalting by size exclusion chromatography in the final step of nothofagin purification. This study therefore, reveals the potential for process intensification in the glycosylation of polyphenol acceptors by glycosyltransferase cascades. It demonstrates that, with up‐ and downstream processing carefully optimized and suitably interconnected, a powerful biocatalytic technology becomes available for the production of an important class of glycosides difficult to prepare otherwise.
Research on the Capital Structure Decisions of China Logistics Industry: Using the Unbalanced Panel Data Analysis

This paper bases on Listed Chinese logistics enterprises samples, from two aspects of static and dynamic to empirically investigate main effect factors of the capital structure, then studies to compare related research results with traditional Chinese manufacturing listed companies, in order to reveal the characteristics of Chinese listed logistics enterprises financing decision and dynamic adjustment, and summarize the corresponding theory through that. The results suggest that financing decisions of Chinese logistics enterprises have a certain difference from the traditional manufacturing enterprises, not only in financing structure establishment, but also in the dynamic adjustment of capital structure, having more mortgage-backed asset, larger size and better profitability are the powerful conditions of rapid financing adjustment for logistics enterprises.
Opportunity Recognition Processes in Entrepreneurial Founder Teams: The Development of Originality and Business Value Across Business Opportunities

This thesis examines the relationship between a prior opportunity's originality and a subsequent opportunity's originality as well as between a prior opportunity's business value and a subsequent opportunity's business value. Additionally, the impacts of human and social capital components on these relationships are analyzed. Based on an experiment with entrepreneurial founder teams, results indicate that team size, entrepreneurial experience, boundary spanning, and cohesion reinforce or attenuate the main effects. This thesis contributes to research on opportunity recognition, creativity, and human and social capital.
Does suppressing luteinising hormone secretion reduce the miscarriage rate? Results of a randomised controlled trial

Abstract Objective: To determine whether prepregnancy pituitary suppression of luteinising hormone secretion with a luteinising hormone releasing hormone analogue improves the outcome of pregnancy in ovulatory women with a history of recurrent miscarriage, polycystic ovaries, and hypersecretion of luteinising hormone. Design: Randomised controlled trial. Setting: Specialist recurrent miscarriage clinic. Subjects: 106 women with a history of three or more consecutive first trimester miscarriages, polycystic ovaries, and hypersecretion of luteinising hormone. Interventions: Women were randomised before conception to receive pituitary suppression with a luteinising hormone releasing hormone analogue followed by low dose ovulation induction and luteal phase progesterone (group 1) or were allowed to ovulate spontaneously and then given luteal phase progesterone alone or luteal phase placebo alone (group 2). No drugs were prescribed in pregnancy. Main outcome measures: Conception and live birth rates over six cycles. Results: Conception rates in the pituitary suppression and luteal phase support groups were 80% (40/50 women) and 82% (46/56) respectively (NS). Live birth rates were 65% (26/40) and 76% (35/46) respectively (NS). In the luteal phase support group there was no difference in the outcome of pregnancy between women given progesterone and those given placebo pessaries. Live birth rates from an intention to treat analysis were 52% (26/50 pregnancies) in the group given pituitary suppression and 63% (35/56) in the controls (NS). Conclusions: Prepregnancy suppression of high luteinising hormone concentrations in ovulatory women with recurrent miscarriage and hypersecretion of luteinising hormone does not improve the outcome of pregnancy. The outcome of pregnancy without pituitary suppression is excellent. Key messages Hypersecretion of luteinising hormone seems not to be causally related to early pregnancy loss Further research should be directed at other endocrine factors controlling implantation Excellent live birth rates can be achieved with supportive care alone in a specialised clinic
Effect of Degree of Encapsulation upon Virulence of Cryptococcus Neoformans. ∗

Summary Thinly encapsulated Cryptococcus neoformans cells were equally as virulent for white Swiss mice as thickly encapsulated cells of the same strain. Yeast cells initially possessing thin capsules promptly developed thick ones upon intracerebral injection into mice, and upon subculture to synthetic capsule medium. Both types of cells produced hydrocephalus to an equal degree. Degree of encapsulation is not a factor in virulence of Cryptococcus neoformans for white Swiss mice.
How Large are the Contributions of Cities to the Development of Rural Communities? A Market Access Approach for a Quarter Century of Evidence from Chile

This article estimates the impact of cities on the economic development of rural communities in Chile, following a market access approach. The effect of the proximity to cities on the development of rural communities is analyzed by estimating the impact of market access on the population, and farm and non-farm employment of rural communities. Using population censuses and remote sensing data, we find, in our preferred estimations, that a 10% higher market access induced a 10%–14% increase in the population of rural communities. Additionally, higher positive elasticities are found in the non-farm sector rather than in the agricultural one. These results widely support the hypothesis of structural change and the diversification of the rural economy for rural communities with better access to markets. Notwithstanding, the evidence also suggests that the farm sector took important advantages from market access in places with better agro-ecological conditions.
Bacillus subtilis Histone-like Protein, HBsu, Is an Integral Component of a SRP-like Particle That Can Bind theAlu Domain of Small Cytoplasmic RNA*

Small cytoplasmic RNA (scRNA) is metabolically stable and abundant in Bacillus subtilis cells. Consisting of 271 nucleotides, it is structurally homologous to mammalian signal recognition particle RNA. In contrast to 4.5 S RNA of Escherichia coli, B. subtilis scRNA contains an Aludomain in addition to the evolutionarily conserved S domain. In this study, we show that a 10-kDa protein in B. subtilis cell extracts has scRNA binding activity at the Alu domain. Thein vitro binding selectivity of the 10-kDa protein shows that it recognizes the higher structure of the Alu domain of scRNA caused by five consecutive complementary sequences in the two loops. Purification and subsequent analyses demonstrated that the 10-kDa protein is HBsu, which was originally identified as a member of the histone-like protein family. By constructing a HBsu-deficientB. subtilis mutant, we showed that HBsu is essential for normal growth. Immunoprecipitating cell lysates using anti-HBsu antibody yielded scRNA. Moreover, the co-precipitation of HBsu with (His)6-tagged Ffh depended on the presence of scRNA, suggesting that HBsu, Ffh, and scRNA make a ternary complex and that scRNA serves as a functional unit for binding. These results demonstrated that HBsu is the third component of a signal recognition particle-like particle in B. subtilis that can bind theAlu domain of scRNA.
Outcomes After Transplantation of Deceased‐Donor Kidneys with Rising Serum Creatinine

The increasing number of candidates for kidney transplantation and relatively unchanged deceased‐donor pool has led to expansion in the criteria for donor acceptability. Outcomes of kidneys from donors with progressively rising creatinine values have not been reported. Patients transplanted between September 2003 and August 2006 with kidneys from donors with peak creatinine levels >2.0 mg/dL were stratified into two groups based on the terminal creatinine and evaluated for outcome: (1) falling creatinine (FC)(n= 27), terminal creatinine at least 0.2mg/dL less than peak, and (2) rising creatinine (RC)(n= 24), terminal creatinine = peak. The mean terminal creatinine was significantly higher in the RC group (3.2 ± 1.3 mg/dL) compared to the FC group (1.9 ± 0.9 mg/dL)(p < 0.0001). Peak creatinine values were similar (RC, 3.2 ± 1.3; FC, 3.1 ± 1.3; p = 0.6521) between the two groups. Rates of delayed graft function (RC, 24%; FC 32%; p = 0.7881) and mean creatinine at follow‐up (RC, 1.6 ± 0.6, FC 1.6 ± 0.4; p = 0.3533) were not significantly different. With a mean follow‐up of 287 ± 274 days, allograft survival was 92% in the RC recipients and 89% in the FC recipients. Under certain conditions, kidneys from donors with rising serum creatinine can be used safely with reasonable early outcomes.
Halal tourism: conceptual and practical challenges

PurposeMuslim tourists participating in halal tourism activities represent a valuable niche market for global tourism industry. The purpose of this study is to clarify the concepts of halal tourism and Islamic tourism and to draw attention to some conceptual and practical challenges in the halal tourism industry.Design/methodology/approachThe paper is based on a critical assessment of the literature in this field. To differentiate the concepts and to discuss practical and conceptual challenges, the authors found some references by reviewing the existing definitions in related literature and the primary source of the concepts which is Holy Book of Islam, Quran.FindingsThe terms “intention” and “Islamic motivation” can be used to differentiate Islamic tourism and halal tourism. The authors suggest calling hotels that provide good and services in halal tourism industry as “halal hotels” and tourists as “Muslim tourists”. One of the leading practical challenges in halal tourism is having lack of halal standards, especially for hotels. As the way Muslims understand and adapt their lives to Islam is quite different, which means this market is not homogenous, the authors suggest that halal hotels should be scaled through different qualifications in different countries.Research limitations/implicationsThis study is based on literature review, and it lacks primary research.Practical implicationsCurrent paper stresses the need for consistent use of Islamic-related tourism terms in industry. Hotel companies should have halal certifications that will provide assurance to customers. It is highly important for hotel companies to inform their target guests about the location of hotel before arriving at hotel. This is because halal hotels and other hotels are usually located in resort destination, especially in Turkey.Originality/valueThis paper is one of the leading papers that differentiates Islamic tourism and halal tourism concepts. It also provides several conceptual and practical issues in halal tourism industry.
Arterial spin‐labeled perfusion combined with segmentation techniques to evaluate cerebral blood flow in white and gray matter of children with sickle cell anemia

Changes in cerebral perfusion are an important feature of the pathophysiology of sickle cell anemia (SCA); cerebrovascular ischemia occurs frequently and leads to neurocognitive deficits, silent infarcts, and overt stroke. Non‐invasive MRI methods to measure cerebral blood flow (CBF) by arterial spin labeling (ASL) afford new opportunities to characterize disease‐ and therapy‐induced changes in cerebral hemodynamics in patients with SCA. Recent studies have documented elevated gray matter (GM) CBF in untreated children with SCA, but no measurements of white matter (WM) CBF have been reported.
New concepts in calcium‐sensing receptor pharmacology and signalling

The calcium‐sensing receptor (CaR) is the key controller of extracellular calcium (Ca2+o) homeostasis via its regulation of parathyroid hormone (PTH) secretion and renal Ca2+ reabsorption. The CaR‐selective calcimimetic drug Cinacalcet stimulates the CaR to suppress PTH secretion in chronic kidney disease and represents the world's first clinically available receptor positive allosteric modulator (PAM). Negative CaR allosteric modulators (NAMs), known as calcilytics, can increase PTH secretion and are being investigated as possible bone anabolic treatments against age‐related osteoporosis. Here we address the current state of development and clinical use of a series of positive and negative CaR modulators. In addition, clinical CaR mutations and transgenic mice carrying tissue‐specific CaR deletions have provided a novel understanding of the relative functional importance of CaR in both calciotropic tissues and those elsewhere in the body. The development of CaR‐selective modulators and signalling reagents have provided us with a more detailed appreciation of how the CaR signals in vivo. Thus, both of these areas of CaR research will be reviewed.
Loss of expression of tuberin and hamartin in tuberous sclerosis complex‐associated but not in sporadic angiofibromas

Background: Angiofibromas occur sporadically, and they develop in most patients with tuberous sclerosis complex (TSC), which is associated with alterations of the tumor suppressor genes TSC1 or TSC2. Loss of tuberin, the protein product of TSC2, has been shown in the interstitial fibroblast compartment of TSC‐associated angiofibromas. It is unclear whether there is also a loss of hamartin, the product of TSC1 in TSC‐associated and sporadic angiofibromas.
Comparison of composition and whey protein fractions of human, camel, donkey, goat and cow milk

The aim of this study was to compare the physicochemical parameters of milk samples of five different species: cow, goat, donkey, camel and human. Also the analysis of whey protein profile in different milk samples was performed by anion-exchange fast protein liquid chromatography (FPLC) while polyacrylamide gel electrophoresis was used to identify a single fraction. Camel milk was the most acid (pH 6.460±0.005) and the richest in total proteins (3.41±0.31 %) and ash (0.750±0.102 %), whereas donkey milk had a neutral pH (7.03±0.02) and characterised by low proteins (1.12±0.40 %) and fat (0.97±0.03 %) content, being very close to human milk. Proteomic analysis of cow, goat, donkey, camel and human milk highlighted significant interspecies differences. Camel milk was similar to human milk in lacking of β-lactoglobulin and richness of α-lactalbumin. The knowledge gained from the proteomic comparison of the milk samples analysed within this study might be of relevance, both, in terms of identifying sources of hypoallergenic alternatives to bovine milk and detection of adulteration of milk samples and products.
Do facilities matter? : The influence of facility satisfaction on perceived labour productivity of office employee

Purpose: Companies spend a lot of money to provide facilities such as a nice, effective and efficient building, well designed ergonomic furniture, sophisticated IT, cleaning services, catering, and safety services. Both from a theoretical perspective as well as from a managerial point of view, it is important to know if and how strongly facilities do affect employee satisfaction and labour productivity. The paper discusses the results of research on this issue. Methods: A brief review of literature and statistical analyses of a database of the Delft Center for People and Buildings, with 2197 respondents from 17 different office environments. The database includes data from Diagnostic Post-Occupancy Evaluations on user satisfaction with regard to the organization, working processes, the office concept and a number of facilities. Findings: Most annual and biannual surveys among Dutch office employees use questionnaires with hardly any questions about the physical environment. Statistical analyses of the Delft database showed a significant but weak correlation between user satisfaction on facilities and self estimated percentage of time that one is being productive. Much stronger correlations came up when satisfaction about facilities is linked to users’ perceptions of the supporting impact of the working environment on ones own productivity. Implications: The results showed statistical support for the added value of facility provisions. But other variables have their impact, too. A more intensive co-operation between scholars, facility managers and Human Resource managers may help to improve our understanding of the complex relationships between the working environment and perceived labour productivity.