Miracle-dz/UniFAR-FTUs huggingface dataset:
About Microservices, Containers and their Underestimated Impact on Network Performance

Microservices are used to build complex applications composed of small, independent and highly decoupled processes. Recently, microservices are often mentioned in one breath with container technologies like Docker. That is why operating system virtualization experiences a renaissance in cloud computing. These approaches shall provide horizontally scalable, easily deployable systems and a high-performance alternative to hypervisors. Nevertheless, performance impacts of containers on top of hypervisors are hardly investigated. Furthermore, microservice frameworks often come along with software defined networks. This contribution presents benchmark results to quantify the impacts of container, software defined networking and encryption on network performance. Even containers, although postulated to be lightweight, show a noteworthy impact to network performance. These impacts can be minimized on several system layers. Some design recommendations for cloud deployed systems following the microservice architecture pattern are derived.
Nonconvulsive electrographic seizures after traumatic brain injury result in a delayed, prolonged increase in intracranial pressure and metabolic crisis

Objective: To determine whether nonconvulsive electrographic post‐traumatic seizures result in increases in intracranial pressure and microdialysis lactate/pyruvate ratio. Design: Prospective monitoring with retrospective data analysis. Setting: Single center academic neurologic intensive care unit. Patients: Twenty moderate to severe traumatic brain injury patients (Glasgow Coma Score 3–13). Measurements and Main Results: Continuous electroencephalography and cerebral microdialysis were performed for 7 days after injury. Ten patients had seizures and were compared with a matched cohort of traumatic brain injury patients without seizures. The seizures were repetitive and constituted status epilepticus in seven of ten patients. Using a within‐subject design, post‐traumatic seizures resulted in episodic increases in intracranial pressure (22.4 ± 7 vs. 12.8 ± 4.3 mm Hg; p < .001) and an episodic increase in lactate/pyruvate ratio (49.4 ± 16 vs. 23.8 ± 7.6; p < .001) in the seizure group. Using a between‐subjects comparison, the seizure group demonstrated a higher mean intracranial pressure (17.6 ± 6.5 vs. 12.2 ± 4.2 mm Hg; p < .001), a higher mean lactate/pyruvate ratio (38.6 ± 18 vs. 27 ± 9; p < .001) compared with nonseizure patients. The intracranial pressure and lactate/pyruvate ratio remained elevated beyond postinjury hour 100 in the seizure group but not the nonseizure group (p < .02). Conclusion: Post‐traumatic seizures result in episodic as well as long‐lasting increases in intracranial pressure and microdialysis lactate/pyruvate ratio. These data suggest that post‐traumatic seizures represent a therapeutic target for patients with traumatic brain injury.
Survey of medication knowledge and behaviors among college students in Taiwan.

OBJECTIVES To survey the knowledge, attitudes, and practices towards safe medication use of first-year college students in Taiwan. METHODS One hundred forty-seven departments in 27 universities were sampled by stratified randomization. Three sections of the questionnaire were developed, including 10 true/false questions to measure knowledge, 4 questions for attitude in a 5-point scale, and 10 questions for practice in a 5-point scale. RESULTS A total of 6270 subjects completed the survey instrument for a valid response rate of 91.9%. Students who were health science majors had safer medication practices than non-health science majors. However, students in both groups had low scores on appropriate antibiotics use, with a correctness rate of 45.8%. Knowledge relating to antacid use had the lowest number of correct responses among the 10 items included in the survey. Overall, the students showed positive attitudes toward (12.6 +/- 2.2) and trusted (3.6 +/- 0.7) pharmacists' consultation. CONCLUSIONS College students lack appropriate knowledge, attitudes, and practices related to the safe use of medications, and efforts are warranted in Taiwan.
NGC 2419–ANOTHER REMNANT OF ACCRETION BY THE MILKY WAY

We isolate a sample of 43 upper red giant branch stars in the extreme outer halo Galactic globular cluster (GC) NGC 2419 from two Keck/DEIMOS slitmasks. The probability that there is more than one contaminating halo field star in this sample is extremely low. Analysis of moderate-resolution spectra of these cluster members, as well as of our Keck/HIRES high-resolution spectra of a subsample of them, demonstrates that there is a small but real spread in Ca abundance of ∼0.2 dex within this massive metal-poor GC. This provides additional support to earlier suggestions that NGC 2419 is the remnant of a dwarf galaxy accreted long ago by the Milky Way.
Correlation between aortic stiffness and left atrial volume index in hypertensive patients

Abstract Background: Both arterial stiffness and left atrial volume index are crucial predictors of cardiovascular outcomes in hypertensive patients. The correlation between these two factors has not been previously well established in hypertensive population. Objectives: To determine the correlation between arterial stiffness and left atrial volume index in hypertensive patients. Methods and results: The study was performed in 111 consecutive hypertensive patients (49.5% male, mean age 70.8 ± 10.3 years) undergoing cardiac magnetic resonance imaging (CMR). Arterial stiffness was determined by pulse wave velocity in the thoracic aorta by velocity-encoded imaging. Left atrial volume was assessed by biplane area-length method. Pulse wave velocity was significantly correlated with left atrial volume index in univariate analysis (r = 0.20, p = 0.032). In multivariate analysis, pulse wave velocity, coronary artery disease and left ventricular mass remain independent predictors (β = 1.01, p = 0.02). Conclusion: Increased arterial stiffness correlates with left atrial enlargement in hypertensive patients. The prevention of left atrial enlargement and subsequent complications by specific antihypertensive drugs with positive effect on aortic stiffness warrants further studies.
Optimum operation of split RF photoinjectors

We describe how to achieve minimum transverse emittance in RF photoinjectors by applying theoretical predictions from a fully analytical model of beam dynamics in a split injector. This device consists of a short two cell (full+partial) RF gun followed by a drift and a booster RF linac. Matching the beam in the booster to the invariant envelope, an equilibrium mode of laminar beam flow, is shown to be the basis of emittance correction. Analytical predictions are compared to numerical simulations, finding excellent agreement. We also show how a further improvement of the beam quality can be obtained by matching the beam out of the booster into a Brillouin flow with proper control of the envelope oscillations. If these are actually coherent plasma oscillations in the laminar regime, then the normalized RMS transverse emittance can be even further reduced.
Sensing of RF Magnetic Fields Using Zeeman Splitting of Double Radiooptical Resonance and a New Approach to Helmholtz Coil Calibrations

We experimentally investigated the resonance interaction of laser, microwave, and radio frequency (RF) fields with Cesium (133Cs) atomic gas. The observed Zeeman components produced by means of an external static magnetic field on the double radiooptical resonance (DROR) were used as a frequency-adjustable RF field detection sensor based on the laser spectroscopy technique. The change in the RF interaction frequency of Zeeman components with the increasing level of the static magnetic field was investigated and linear dependence of the RF interaction frequency of the Zeeman components on the external static magnetic field was observed. In addition, the change in the amplitude of the Zeeman components with the level of RF fields was investigated and an approximately linear relation in certain regions was detected. We also studied the relation of the Zeeman component amplitudes with laser and microwave powers. Finally, a new approach to Helmholtz coil calibrations by using this atomic sensor is discussed.
Bradykinin B2 receptor involvement in rabbit and murine models of septic shock.

The purpose of our work was to evaluate the role of bradykinin B2 receptors in the early phase (first 3 h) of bacterial lipopolysaccharide (LPS)-induced shock in anesthetized and mechanically ventilated rabbits and to determine if HOE 140, a specific, potent, and long-acting bradykinin B2-receptor antagonist, could improve survival in two murine models of septic shock. In rabbits, LPS injection induced rapid hypotension associated with metabolic acidosis. Three hours after the injection of LPS, we observed leukopenia, thrombocytopenia, and a moderate increase in arterial blood cyclic GMP. The injection-of HOE 140 [1.7-mumol/kg bolus intravenously (i.v.) 20 min before LPS] inhibited the decrease in blood pressure, but did not influence any of the other parameters studied. Mice were subjected to intraperitoneal (i.p.) injection of LPS, which induced almost 100% mortality in the 4 days after the injection. Pretreatment with HOE 140 (1 mg/kg i.p.) 30 min before the LPS injection and 4, 8, and 24 h afterward the injection did not improve survival at any given time during the 4 days of the study. Cecal ligation and puncture in mice induced a mortality rate > 90% in < or = 10 days. HOE 140 (1 mg/kg i.v.) given 30 min before cecal ligation did not significantly improve the survival rate. In contrast with previous reports, in the present study in a rabbit model of endotoxic shock (early phase) and in two murine models of septic shock, the involvement of bradykinin B2 receptors appeared to be minimal.
CHI3L1 (YKL‐40) is expressed in human gliomas and regulates the invasion, growth and survival of glioma cells

Chitinase 3‐like 1 (CHI3L1) is a secreted glycoprotein that has pleiotropic activity in aggressive cancers. In our study, we examined the expression and function of CHI3L1 in glioma cells. CHI3L1 was highly expressed in human glioma tissue, whereas its expression in normal brain tissue was very low. CHI3L1 suppression by shRNA reduced glioma cell invasion, anchorage‐independent growth and increased cell death triggered by several anticancer drugs, including cisplatin, etoposide and doxorubicin, whereas CHI3L1 overexpression had the opposite effect in glioma cells. Because the invasive nature of glioma cells plays a critical role in the high morbidity of glioma, we have further defined the role of CHI3L1 in the process of glioma invasion. Downregulation of CHI3L1 results in decreased cell–matrix adhesion and causes a marked increase in stress fiber formation and cell size with fewer cellular processes. Furthermore, the expression and activity of matrix metalloproteinase‐2 was also decreased in glioma cells in which CHI3L1 was knocked down. Taken together, these results suggest that CHI3L1 plays an important role in the regulation of malignant transformation and local invasiveness in gliomas. Thus, targeting the CHI3L1 molecule may be a potential therapeutic molecular target for gliomas.
Knowledge of, attitudes toward, and experience of complementary and alternative medicine in Western medicine- and oriental medicine-trained physicians in Korea.

OBJECTIVES We compared knowledge of, attitudes toward, and experience with complementary and alternative medicine (CAM) among Western medicine-trained doctors (WMDs) and Oriental medicine-trained doctors (OMDs). METHODS In Korea, 502 WMDs and 500 OMDs were interviewed with a structured questionnaire. RESULTS OMDs held more favorable attitudes toward CAM than did WMDs. OMDs possessed a deeper understanding of and greater experience with CAM. OMDs more readily endorsed health beliefs congruent with CAM. CONCLUSIONS In the future, CAM can be more readily used by OMDs than by WMDs. Because evidence for the effectiveness of CAM remains sparse, more research is needed for the prudent use of CAM in Korea. An education and training system for potential CAM providers remains to be developed.
An Efficient Simulated Annealing Approach to the Travelling Tournament Problem

Scheduling sports leagues has drawn significant attention to itself in recent years, as it involves considerable revenue as well as challenging combinatorial optimization problems. A particular class of these problems is the Traveling Tournament Problem (TTP) which focuses on minimizing the total traveling distance for teams. In this paper, an efficient simulated annealing approach is presented for TTP which applies two simultaneous and disparate models for the problem in order to search the solutions space more effectively. Also, a computationally efficient modified greedy scheme is proposed for constructing a favorable initial solution for the simulated annealing algorithm. Our computational experiments, carried out on standard instances, demonstrate that this approach competes with previous offered methods in quality of found solutions and their computational time.
Early Thai Bronze: Analysis and New Dates

Electron probe analysis of the earliest metal found at the northeastern Thailand site of Non Nok Tha indicates that it is a bronze containing 4 to 6 percent tin. Recent thermoluminescence dates substantiate the presence of a well-developed bronze technology prior to 2300 B.C. and suggest a date of about 2700 to 2500 B.C. for the first appearance of bronze at the site.
Detection of the osmoregulator betaine in methanogens

Trimethyl glycine (glycine betaine) was detected by 13C nuclear magnetic resonance spectroscopy at high intracellular concentrations in several methanogens (Methanogenium cariaci, "Methanogenium anulus" AN9, Methanohalophilus zhilinae, Methanohalophilus mahii, and Methanococcus voltae) grown on marine media containing yeast extract. 13C labeling studies with Methanogenium cariaci suggested that the betaine which accumulated inside the cells was not synthesized de novo but was transported in from the medium. Proof of such a transport system was provided by growing Methanogenium cariaci on yeast-free medium supplemented with betaine. Under these conditions, betaine was the dominant osmoregulator.
Classification of RNA Pseudoknots and Comparison of Structure Prediction Methods. (Classification de Pseudo-nœuds d'ARN et Comparaison de Méthodes de Prédiction de Structure)

Lots of researches convey the importance of the RNA molecules, as they play vital roles in many molecular procedures. And it is commonly believed that the structures of the RNA molecules hold the key to the discovery of their functions.During the investigation of RNA structures, the researchers are dependent on the bioinformatical methods increasingly. Many in silico methods of predicting RNA secondary structures have emerged in this big wave, including some ones which are capable of predicting pseudoknots, a particular type of RNA secondary structures.The purpose of this dissertation is to try to compare the state-of-the-art methods predicting pseudoknots, and offer the colleagues some insights into how to choose a practical method for the given single sequence. In fact, lots of efforts have been done into the prediction of RNA secondary structures including pseudoknots during the last decades, contributing to many programs in this field. Some challenging questions are raised consequently. How about the performance of each method, especially on a particular class of RNA sequences? What are their advantages and disadvantages? What can we benefit from the contemporary methods if we want to develop new ones? This dissertation holds the confidence in the investigation of the answers.This dissertation carries out quite many comparisons of the performance of predicting RNA pseudoknots by the available methods. One main part focuses on the prediction of frameshifting signals by two methods principally. The second main part focuses on the prediction of pseudoknots which participate in much more general molecular activities.In detail, the second part of work includes 414 pseudoknots, from both the Pseudobase and the Protein Data Bank, and 15 methods including 3 exact methods and 12 heuristic ones. Specifically, three main categories of complexity measurements are introduced, which further divide the 414 pseudoknots into a series of subclasses respectively. The comparisons are carried out by comparing the predictions of each method based on the entire 414 pseudoknots, and the subsets which are classified by both the complexity measurements and the length, RNA type and organism of the pseudoknots.The result shows that the pseudoknots in nature hold a relatively low complexity in all measurements. And the performance of contemporary methods varies from subclass to subclass, but decreases consistently as the complexity of pseudoknots increases. More generally, the heuristic methods globally outperform the exact ones. And the susceptible assessment results are dependent strongly on the quality of the reference structures and the evaluation system. Last but not least, this part of work is provided as an on-line benchmark for the bioinformatics community.
Spontaneous Dissections of the Carotid Arteries in a Patient with Recent Coronary Artery Dissection

pravastatin 20 mg daily. Post-myocardialinfarction echocardiography had demonstrated anteroseptoapical hypokinesia with low left ventricular ejection fraction (50%). On admission, right hemiparesis and aphasia had cleared. The patient had no history of recent infection (no fever, no flu, no respiratory tract symptoms) and reported no prior transient neurological deficit, headache or cervical pain. No Horner’s syndrome was observed. The patient had no skin, joint, eye or skeletal abnormalities suggesting a hereditary connective tissue disorder. No family history of arterial dissection or valvular heart disease was noted. Multimodal MRI performed on June 27 showed no recent ischemic lesion on diffusion-weighted imaging. T 2 -weighted sequences showed bilateral middle cerebral artery/anterior cerebral artery borderzone hyperintensities. Magnetic resonance angiography showed occlusion of the right ICA beginning 1 cm after the bifurcation and narrow stenosis of the left ICA in the subpetrous segment consistent with the diagnosis of bilateral spontaneous ICA dissection ( fig. 2 ). Collateral supply was efficient through the right posterior communicating artery. No intramural hematoma was observed. No angiographic changes of fibromuscular dysplasia were found. Neck Dear Sir, Multiple dissections of the carotid and coronary arteries are exceptional [1] . We report the case of a young woman without known hereditary connective tissue disorder who presented with spontaneous dissection of the left anterior descending coronary artery, followed by spontaneous dissection of both internal carotid arteries (ICA) 3 weeks later. We discuss the pathogenesis of these multiple dissections.
Error diffusion with ink reduction for high quality and high resolution ink jet printing

This paper describes a new error diffusion technique with an ink reduction model to achieve high quality and high resolution (600 dpi and above) ink jet printing. Variable-sized error filters are designed in the ink reduction model to prevent ink overflow on media and also to maintain smooth halftone microstructures without worm-like artifacts. Experimental results are shown to show the effectiveness of the technique.
Topical delivery of aceclofenac as nanoemulsion comprising excipients having optimum emulsification capabilities: preparation, characterization and in vivo evaluation

Objective: The aim of the present study was to investigate the potential of a nanoemulsion for topical delivery of aceclofenac using different excipients having optimum emulsifying ability rather than their solubilizing capacity. Methods: The oil-in-water nanoemulsions were prepared by screening the excipients from the nanoemulsion region of pseudoternary phase diagram. The prepared nanoemulsions were subjected to different thermodynamic stability tests. The nanoemulsion formulations that passed thermodynamic stability tests were characterized for viscosity, droplet size, transmission electron microscopy, refractive index and in vitro skin permeation. The in vitro skin permeation profile of optimized nanoemulsion formulation (NE31, containing 23.85% Polyoxy-35-castor oil, 7.95% PEG 400 and 13.6% Triacetin) was compared with that of nanoemulsion gel (NG31) and marketed gel formulation (HIFENAC GEL (HIG)). In vivo anti-inflammatory efficacy studies were also carried out for NE31, NG31 and HIG. Results: The significant (p < 0.001) increase in in vitro permeability and in vivo anti-inflammatory efficacy of the NG31 formulation was observed as compared with HIG formulation. Conclusion: It can be concluded that the selection of surfactant and cosurfactant on the basis of their emulsification capabilities other than the solubilizing capacity of drug is an important criterion for the formulation of nanoemulsion.
Tumor necrosis factor-alpha cell-surface receptors of liver parenchymal and nonparenchymal cells during acute and chronic alcohol administration to rats.

Tumor necrosis factor-alpha (TNF-alpha) has been shown to contribute to the alcohol [ethanol (ETOH)]-induced alteration of hepatic function. Therefore we tested the hypothesis that the hepatic action of TNF-alpha could be due, at least in part, to alterations in TNF-alpha cell-surface receptors of hepatic parenchymal (hepatocytes) and nonparenchymal (Kupffer and sinusoidal endothelial) cells. Rats were either acutely treated with ETOH by a primed, continuous 7-hr intravenous infusion of 20% (w/v) ETOH (30 mg/100 g body weight/h) or chronically fed an ETOH-containing liquid diet (5.2% ETOH, w/v, with ETOH as 36% of total calories) for 14 weeks. Control rats in the acute group were infused with sterile saline, whereas control rats in the chronic group were fed liquid diet containing dextrin to replace ETOH in isocaloric amounts. Three hr before killing, the rats were injected intravenously with Gram-negative bacterial lipopolysaccharide [(LPS) 100 micrograms/100 g body weight] or saline. Hepatocytes, Kupffer cells, and sinusoidal endothelial cells were isolated after liver perfusion with collagenase (without pronase), separated by centrifugal elutriation, and used to determine the affinity (Kd) and capacity (Bmax) of binding sites, using recombinant human-[125I]TNF-alpha as the ligand. Two binding sites were detected on Kupffer cells and sinusoidal endothelial cells isolated from control animals: a high-affinity (Kd1, in the range of 150-200 pM), low-capacity (Bmax, in the range of 2-3 fmol/10(6) cells) binding site and a low-affinity (Kd2, in the range of 2-9 nM), high-capacity (Bmax2, in the range of 3-15 fmol/10(6) cells) binding site. (ABSTRACT TRUNCATED AT 250 WORDS)