Miracle-dz/UniFAR-FTUs huggingface dataset:
Mentoring beginning teachers and goal setting

Australia has delineated a new direction for teacher education by embedding mentoring programs for teachers who support early-careers teachers as a system approach. This case study investigated how mentors after involvement in a mentoring professional learning program focused on goal setting with beginning teachers in their schools. Data were analysed from six mentors’ interviews using semi-structured questions and archival documents associated with the mentoring program. Findings revealed that negotiated goal setting facilitates potentially successful teaching practices that align to career stage standards. Other findings associated with goal setting are reported around: (1) mentor-mentee relationships, (2) roles, skills and responsibilities, (3) specific goal setting, and (4) the Australian Professional Standards for Teachers. Further research (qualitative paired mentor-mentee partnerships and large quantitative studies) will provide insights on effective uses of goal setting that align with standardised frameworks and connect with effective teaching practices.
STAT‐1: a novel regulator of apoptosis

Summary. Extracellular signalling molecules binding to their specific receptors are able to modulate gene expression, leading to changes in development, cell growth and homeostasis. The signal transducers and activators of transcription (STAT) protein family members are among the best studied of the latent cytoplasmic signal‐dependent transcription factors. The STAT factors are activated via phosphorylation on the C‐terminal domain following cytokine signalling or by various stress‐induced stimuli. Recently, STAT‐1 has been implicated in modulating pro‐ and anti‐apoptotic genes following several stress‐induced responses. These effects are dependent on STAT‐1 phosphorylation on serine‐727 and require the C‐terminal transactivation domain of STAT‐1 to enhance its pro‐apoptotic effect or inhibit its anti‐apoptotic effects. The STAT‐1 C‐terminal domain has been demonstrated to be important for protein–protein interaction with other transcriptional activators. The reports that STAT‐1‐deficient mice develop spontaneous and chemically induced tumours more rapidly compared to wild‐type mice and that STAT‐1‐deficient cells are more resistant to agents that induce apoptosis strongly support the argument that STAT‐1 acts as a tumour suppressor.
Investigating grammatical complexity in Gulf Arabic speaking children with specific language impairment (SLI)

This is the first investigation of Specific Language Impairment (SLI) in Gulf-Arabic (GA) speaking children. The thesis consists of two main sections, in the first one, I discuss the definitions of SLI and the various theories put forward to account for the deficits seen in this population. I also discuss the importance of cross-linguistic investigations of SLI and why studying SLI in GA may prove useful in testing the accounts of SLI that argue for a general processing deficit vs. those that argue for a domain specific account of SLI. The remaining section of the first part is dedicated to describing the various language tests developed to identify children with SLI in GA. These tests were conducted with approximately 88 typically developing children and 26 children with SLI between the age of 4;6 and 9;4 years old. In the second part of the thesis, I report on two experiments investigating syntactic and phonological complexity in GA speaking children with SLI. The first experiment investigates the comprehension of three types of word orders: a canonical SVO, and two word orders that involve fronting of the direct object (OSV and OVS). Results showed that children with SLI differed from the TD groups on the sentences with fronted NP's, but not on the canonical word order. The second experiment involves a nonword repetition test where syllable length and consonant clusters are systematically controlled to contrast the influence of both phonological short-term memory and phonological complexity. The results are consistent with accounts that argue for a significant role of phonological complexity in NWR and question the “centrality” of phonological capacity in nonword repetition. The final chapter summarises the findings of the thesis and its contribution to theories of SLI in general, and to the study of SLI in Arabic in particular.
NMDA receptor in intestinal enteroendocrine cell, STC-1

We earlier showed that intestinal STC-1 cells can respond to five basic taste stimuli. Here, we investigated which receptors or channels are involved in the sensing of umami in STC-1 cells. T1R family and metabotropic glutamate receptors were not involved. In contrast, we found that N-Methyl-D-aspartate (NMDA) receptors are expressed in STC-1 cells by RT-PCR analysis. Using a calcium-imaging technique, we also observed that a specific agonist NMDA induces the increase in the intracellular Ca2+ concentration in STC-1 cells. We also found that pretreatment with NMDA enhances sweet-induced response in STC-1 cells, suggesting important roles of L-Glu-signaling in the chemosensory system of the gastrointestinal tracts.
Expression of epidermal growth factor receptor correlates with disease relapse and progression to androgen-independence in human prostate cancer.

PURPOSE The transforming growth factor alpha-epidermal growth factor receptor (EGFR) autocrine pathway has been implicated in prostate cancer cell growth. Amplification and/or overexpression of c-erbB-2, a receptor closely related to the EGFR, has been recently involved in prostate cancer progression. We investigated EGFR and c-erbB-2 expression in primary androgen-dependent and in advanced androgen-independent prostate cancer and their potential role as markers of disease progression. EXPERIMENTAL DESIGN EGFR and c-erbB-2 expression were evaluated by immunohistochemistry in a consecutive series of 74 prostate cancer patients with the following characteristics: 29 patients (group 1) treated with radical prostatectomy; 29 patients (group 2) treated with luteinizing hormone-releasing hormone analogues and antiandrogen therapy followed by radical prostatectomy; and 16 patients with hormone-refractory metastatic disease. In all patients we evaluated: association between EGFR and/or c-erbB-2 expression and clinicopathological parameters; and disease-free survival according to EGFR and c-erbB-2 expression in univariate analysis (Kaplan-Meier product-limit method) and in multivariate analysis (Cox proportional hazards regression model). RESULTS EGFR expression was found in 12 of 29 (41.4%) group 1 patients, in 22 of 29 (75.9%) group 2 patients (P < 0.0005), and in 16 of 16 (100%) metastatic patients (P < 0.005), whereas c-erbB-2 expression was found in 11 of 29 (37.9%) group 1, in 10 of 29 (34.5%) group 2 patients, and in 9 of 16 (56.3%) metastatic patients. A significant association was found between EGFR expression and a high Gleason score (P < 0.01) and between EGFR expression and higher serum prostate-specific antigen values (P < 0.02) in all groups of patients. Among the 58 patients treated with radical prostatectomy, 23 of 34 EGFR-positive patients (67.6%) relapsed, whereas only 2 of 24 EGFR-negative patients (8.3%) relapsed (P < 0.00004). c-erbB-2 expression did not significantly correlate with disease relapse (P = 0.07). In a Cox multivariate analysis, the only parameter with an independent prognostic effect on disease-free survival was EGFR expression (relative hazard, 11.23; P = 0.0014). CONCLUSIONS EGFR expression increases during the natural history of prostate cancer. Correlation with disease progression and hormone-refractory disease suggests that EGFR-targeted drugs could be of therapeutic relevance in prostate cancer.
Social Persistence Following Failure in Boys and Girls with LD

The response of boys and girls with or without learning disabilities to social failure was examined. Children participated in two dyadic interactions with experimental confederates: an unfriendly interaction and a friendly one. The children's behavior was videotaped, and they answered questions following each interaction. The children with learning disabilities were found to be hyperresponsive to both interactions: They felt significantly worse following the unfriendly one and significantly better following the friendly interaction. Limited evidence was found to suggest that girls with. learning disabilities were more adversely affected by the unfriendly interaction. Several of the findings were consistent with the hypothesis that children with learning disabilities show a learned helplessness response to social failure. The implications of these findings for understanding the social behavior of children with learning disabilities are discussed.
Shifting the balance of power? Culture change and identity in an English health-care setting.

PURPOSE A recurring theme in Government policy documents has been the need to change the culture of the NHS in order to deliver a service "fit for the twenty-first century". However, very little is said about what constitutes "culture" or how this culture change is to be brought about. This paper seeks to focus on an initiative aimed ostensibly at "empowering" staff in an English Primary Care Trust as a means of changing organisational culture. DESIGN/METHODOLOGY/APPROACH It presents findings from an ethnographic study which suggests that this attempt at "culture change" is aimed at manipulating the behaviour and values of individual employees and may be interpreted as a process of changing employee identity. FINDINGS Employees reacted in different ways to the empowerment initiative, with some resisting attempts to shape their identity and others actively engaging in projects to bring their unruly self into line with the ideal self to which they were encouraged to aspire. ORIGINALITY/VALUE The challenges presented by the need to respond to conflicting Government policies created tensions between individuals and conflicts of allegiance and identity within individual members of staff. Alternative forms of self-hood did not merely replace existing identities, but interacted with them, often uncomfortably. The irony is that, whilst Government seeks to promote culture change, the frustrations created by its top-down target-driven regime acted to mitigate the transformational and reconstitutive effects of a discourse of empowerment aimed at achieving this change.
Male Self-Employment in Four European Countries

Abstract: This article investigates the patterns of male nonagricultural self-employment in France, Gennany, Italy, and the United Kingdom. It is argued that the development of self-employment in these four countries is based on specific institutional and economic frameworks resulting in different opportunities and incentives for taking up self-employment. These differences affect the relevance of individual resources like education and work experience. The empirical analyses are based on national Labor Force Surveys. Although we find a remarkable number of common general patterns in self-employment in all four countries, the findings also indicate that educational requirements and the relevance of age-related experience differ fundamentally among the four countries and along industrial branches. Specific regulations and general settings in single branches and countries result in distinct opportunities for self-employment.
Schwannoma of the sinonasal tract: a clinicopathologic and immunohistochemical study of 5 cases.

CONTEXT Peripheral nerve sheath tumors are soft tissue neoplasms rarely encountered in the nasal cavity and paranasal sinuses. OBJECTIVE To describe the clinicopathologic and immunohistochemical features of a series of schwannomas of the sinonasal tract. DESIGN Surgical pathology files were searched for the diagnosis "sinonasal schwannoma. " All histologic documents and clinical data were reviewed. Immunohistochemistry was performed on paraffin-embedded tissue with antibodies to S100 protein, epithelial membrane antigen, CD34, and MIB-1. RESULSTS: Five cases of sinonasal schwannoma were retrieved; patients included 3 women and 2 men, aged 20 to 56 years. Three cases were located in the ethmoid sinus. Clinical symptoms were nonspecific (nasal obstruction, epistaxis, and anosmia). All tumors were treated with conservative surgical resection. Pathologic examination showed a spindle cell proliferation without encapsulation in all cases. No cytologic atypia was seen, and the mitotic activity was low (<3 mitotic figures/10 high-power fields). Immunohistochemistry showed diffuse positivity with S100 protein and negativity with CD34 and epithelial membrane antigen. MIB-1 staining was low (1%-5% of tumor cell nuclei stained). During the follow-up (median, 6 years), no recurrence or metastasis was observed. CONCLUSIONS Schwannoma is a very unusual tumor of the sinonasal tract and is associated with nonspecific symptoms. Histologically, sinonasal schwannomas differ from schwannomas of other locations by their lack of a peripheral capsule and possible ulceration of the epithelial covering. Sinonasal schwannomas are treated with conservative surgical resection and have an excellent prognosis.
Alveolar liquid and protein clearance from normal dog lungs.

To determine whether liquid and protein clearance from the air spaces and lungs of anesthetized and unanesthetized dogs is the same as in sheep, we quantified these variables at three different time periods (4, 8, and 12 h) by instilling heparinized plasma (3 ml/kg) labeled with 125I-albumin into one lower lobe. Protein clearance, measured from the residual 125I-albumin in the lung homogenate, was slow and monoexponential (approximately 1%/h), similar to our previous data for protein clearance from the lungs in sheep. Lung liquid clearance in dogs, however, was 50% less than in previous experiments in sheep. Residual lung liquid (as percent of instilled) was 88.7 +/- 7.0 at 4 h, 70.5 +/- 9.1 at 8 h, and 64.0 +/- 5.8 at 12 h. At each time period, alveolar protein concentration increased by 0.6 +/- 0.4 g/dl at 4 h, 1.3 +/- 1.2 g/dl at 8 h, and 2.1 +/- 0.8 g/dl at 12 h. This increase in alveolar protein concentration was proportional to the volume of liquid removed from the lungs. beta-Adrenergic agonist therapy with terbutaline (10(-5) M mixed with the instilled plasma) doubled the volume of liquid cleared from the lungs over 4 h, and the alveolar protein concentration increased proportionally. However, lung liquid clearance in dogs that were treated with beta-agonists was proportionally (50%) less than in sheep treated with beta-agonists. The slower liquid clearance in dogs compared with sheep cannot be explained by differences in hemodynamics, pulmonary blood flow, anesthesia, mode of ventilation, or alveolar surface area. (ABSTRACT TRUNCATED AT 250 WORDS)
Neural Block Sampling

Efficient Monte Carlo inference often requires manual construction of model-specific proposals. We propose an approach to automated proposal construction by training neural networks to provide fast approximations to block Gibbs conditionals. The learned proposals generalize to occurrences of common structural motifs both within a given model and across models, allowing for the construction of a library of learned inference primitives that can accelerate inference on unseen models with no model-specific training required. We explore several applications including open-universe Gaussian mixture models, in which our learned proposals outperform a hand-tuned sampler, and a real-world named entity recognition task, in which our sampler's ability to escape local modes yields higher final F1 scores than single-site Gibbs.
Anthropometry and Barbell Trajectory in the Snatch Lift for Elite Women Weightlifters

Abstract Musser, LJ, Garhammer, J, Rozenek, R, Crussemeyer, JA, and Vargas, EM. Anthropometry and barbell trajectory in the snatch lift for elite women weightlifters. J Strength Cond Res 28(6): 1636–1648, 2014—The primary objective of this study was to examine relationships between anthropometry and horizontal barbell displacement during the pulling phase of the snatch lift (SN) in elite women weightlifters. Secondary objectives included description of anthropometric and displacement characteristics, and examinations of SN performance and competitive experience. Thirty-six women weightlifters competing at the 2009 Pan American Championships participated. Participants were measured for standing height, upper limb, trunk, thigh, and shank lengths, and completed a questionnaire about competition and training experience. Horizontal displacement from lift-off to first pull maximum (Dx1) and from first pull to second pull maximum (Dx2) was determined from the heaviest successful SN using 2-dimensional video analysis. Significant correlations (p ⩽ 0.05) existed between thigh and lower-limb lengths and Dx2 in 53 kg participants; lower-limb length and Dx1 in 75 kg participants; and horizontal displacement and body segment ratios involving the upper and lower extremity in multiple weight classes. Correlations between anthropometry and Dx1 also reached significance with participants grouped by barbell trajectory type. Except for the trunk and thigh, body segment lengths were significantly different (p ⩽ 0.05) between weight classes. Significantly different body proportions existed in 48 kg participants compared with all other classes. Multiple thigh and trunk variables were significantly correlated with performance. Horizontal displacement values were similar to previous reports in the literature. Few significant relationships existed between displacement and performance, and none were found for competitive experience. Understanding relationships between anthropometry and barbell trajectory may be useful for optimizing SN technique.
Institutions for Managing Resilient Salmon ( Oncorhynchus Spp.) Ecosystems: the Role of Incentives and Transaction Costs

Institutions are the mechanisms that integrate the human and ecological spheres. This paper discusses the institutional challenge of integrating salmon (Oncorhynchus spp.) ecosystems and human systems in ways that effectively promote resilience. Salmon recovery in the Columbia River Basin demonstrates the challenge. Despite the comprehensive scope of Basin salmon management, it has a number of problems that illustrate the difficulties of designing institutions for ecosystem and human system resilience. The critical elements of salmon ecosystem management are incentives and transaction costs, and these comprise a large piece of missing institutional infrastructure. Once the focus is placed on incentives and costs, a number of different management strategies emerge as options for salmon ecosystems, including refugia, property rights to ecosystem goods and services, co-management, and markets in ecosystem services.
Effects of Silymarin MZ-80 on Hepatic Oxidative Stress in Rats with Biliary Obstruction

This study was designed to evaluate the effects of three pharmaceutical forms of silymarin (silymarin MZ-80, silybinin-β-cyclodextrin, and silybinin) on the liver oxidative status in vitro and after oral administration to rats with extrahepatic biliary obstruction (EBO) and sham-operated animals. We evaluated thiobarbituric acid-reactive substances (TBARS), glutathione (GSH + GSSG) and their related enzyme activities (GSH peroxidase, GSSG reductase and GSH transferase). All three compounds inhibited the in vitro production of TBARS (IC50 56–533 µmol/l). These compounds, mainly silymarin MZ-80, also increased GSH peroxidase and GSH transferase activities. In EBO rats we found increases in TBARS production which was inhibited by 50–70% after treatment. Glutathione was reduced by 55% and elevated by silymarin MZ-80. GSH transferase increased in the group given silymarin MZ-80. We conclude that all three derivatives of silymarin show a clear ability to reduce lipid peroxidation in the liver. Silymarin MZ-80 was the only compound that enhanced the glutathione antioxidant system.
Alveolar bone loss around incisors in Class I bidentoalveolar protrusion patients: a retrospective three-dimensional cone beam CT study.

OBJECTIVES The aim of this study was to test the null hypothesis that there is no difference in the alveolar bone thickness, bone loss or incidence of fenestrations between upper and lower incisors in skeletal Class I bidentoalveolar protrusive patients before orthodontic treatment. METHODS Three-dimensional (3D) cone beam CT (CBCT) images were taken of 24 patients from the Republic of Korea (17 females and 7 males). Reformatted CBCT images were used to measure labial and lingual alveolar bone thickness (ABT) of the 4 upper incisors and 4 lower incisors of the 24 patients (total n = 192 incisors) at every 1/10 of root length (Level 0, cementoenamel junction (CEJ) area; Level 10, root apex area) as well as alveolar bone area (ABA) and alveolar bone loss (%BL) rate to dental root length. The numbers of fenestration teeth were also tallied. RESULTS All anterior teeth were supported by <1 mm of ABT on the labial surfaces up to root length Level 8. ABA was statistically greater on the lingual aspect than the labial aspect in lower incisors. The %BL was 26.98% in the lower labial region, 19.27% in upper labial aspect and most severe on the lower lingual plate 31.25% compared with the labial plate. There were no significant differences in %BL between subgroups when categorized by sex or age. Fenestrations were 1.37 times more frequent on lower incisors (37) than upper incisors (27). CONCLUSION The null hypothesis was rejected, confirming that incisor periodontal support is poor and alveolar bone loss is severe even prior to the start of orthodontic treatment. Careful diagnosis using 3D CBCT images is needed to avoid iatrogenic degeneration of periodontal support around anterior teeth, particularly in the lower lingual bone plate region.
Fiscal Autonomy and Economic Growth Nexus: Empirical Evidence from Pakistan

The study investigates the impact of fiscal decentralization on economic growth in Pakistan using time series data for the period from 1972 to 2010. The empirical results show that fiscal decentralization (revenue and expenditures) is an effective tool to foster the economic growth in Pakistan. The increase in the subnational share of total government expenditures may generate more projects geared toward development and improve the overall level of development in Pakistan. It was found that and increase in the subnational revenue share in total government revenue also has a positive relationship with economic growth. In Pakistan, fiscal decentralization has significant and positive influence on economic growth but being a developing economy the numbers of constraints which can curb the effectiveness of fiscal decentralization are greater than developed economies.