Miracle-dz/UniFAR-FTUs huggingface dataset:
Inconsistency in hypnotic age regression and cue structure as supplied by the hypnotist.

Ss to write a complex sentence, in contexts that varied appreciably in the extent to which they cued Ss that illogical response was appropriate. Hypnotically responsive and unresponsive Ss were assigned to a real or simulating group in application of the real-simulating model of hypnosis and tested in 1of 3 distinct cue conditions. Cue conditions either followed those of previous studies and communicated that no particular response was appropriate, or communicated that an illogical response was appropriate, or inappropriate. It was hypothesized that cue structure would have a significant impact. Data indicated that cues for logical response had a greater influence on the behavior of Ss than did cues for illogical response when compared with the base response condition; at times, real Ss behaved appreciably more illogically than simulating Ss. Also, detailed analysis of the reports of both groups of Ss indicated distinctive properties of experience that point to the importance of recognizing the complexities of consciousness underlying the experiences of highly susceptible Ss.
Repeatability of quantitative CT indexes of emphysema in patients evaluated for lung volume reduction surgery.

PURPOSE To evaluate the repeatability of quantitative computed tomographic (CT) indexes of emphysema and the effect of spirometric gating of lung volume during CT in candidates for lung volume reduction surgery (LVRS). MATERIALS AND METHODS Initial and same-day repeat routine inspiratory spiral chest CT studies were performed in 29 LVRS candidates (group 1, routine study vs repeat study). In a separate cohort of 29 LVRS candidates, spiral chest CT studies were performed both without and with spirometric gating by using a spirometer to trigger scanning at 90% of vital capacity (group 2, spirometric gating study). In each study, Pearson and intraclass correlation coefficients were calculated to determine the agreement between multiple pairs of whole-lung quantitative CT indexes of emphysema, and mean values were compared with two-tailed paired t tests. RESULTS Pearson and intraclass correlation coefficients were high for all quantitative CT indexes (all > or = 0.92). No significant differences were found between mean values of quantitative CT indexes in group 1. Variation in quantitative CT results was small but more prominent in group 2 than in group 1. The variation in quantitative CT results was primarily related to differences in lung volume (r(2) as great as 0.83). CONCLUSION Repeatability of quantitative CT test results in LVRS candidates is high and unlikely to improve by using spirometric gating.
The risk of complications of uveitis in a district hospital cohort

Aims: To establish the frequency and risk factors for visual loss in a primary referral cohort of hospital patients with uveitis. Methods: 561 consecutive uveitis patients attending three district hospitals were recruited and the acuity at the end of the study period recorded. A retrospective case-control study of risk factors for visual loss (permanent loss of acuity <6/9) was performed. Risk factors examined included type of uveitis, age at onset of uveitis, race, type of systemic inflammatory disease, length of follow up, and treatment variables. Results: Visual loss of at least 6/12 in one eye was found in 111 patients (19.9%). Only four patients (0.7%) suffered severe bilateral visual loss (6/36 or less). Visual loss was associated with age at onset >60 years (odds ratio 3.9, 95% confidence interval (CI) 2.2 to 7.0, long follow up 2.0 (1.2 to 3.3) and a history of cataract surgery 3.9 (2.1 to 7.2). It was less likely in patients with acute anterior uveitis 0.2 (0.1 to 0.3). Conclusion: The frequency of visual loss associated with uveitis in a district hospital cohort is less than that found in referral centres and levels of legal blindness are low. Although acute anterior uveitis has a low frequency of visual loss it contributes significantly to the total burden. The ocular co-morbidity of the elderly may contribute to the increased visual loss of late onset uveitis.
EEG biomarkers in major depressive disorder: Discriminative power and prediction of treatment response

Abstract Major depressive disorder (MDD) has high population prevalence and is associated with substantial impact on quality of life, not least due to an unsatisfactory time span of sometimes several weeks from initiation of treatment to clinical response. Therefore extensive research focused on the identification of cost-effective and widely available electroencephalogram (EEG)-based biomarkers that not only allow distinguishing between patients and healthy controls but also have predictive value for treatment response for a variety of treatments. In this comprehensive overview on EEG research on MDD, biomarkers that are either assessed at baseline or during the early course of treatment and are helpful in discriminating patients from healthy controls and assist in predicting treatment outcome are reviewed, covering recent decades up to now. Reviewed markers include quantitative EEG (QEEG) measures, connectivity measures, EEG vigilance-based measures, sleep–EEG-related measures and event-related potentials (ERPs). Further, the value and limitations of these different markers are discussed. Finally, the need for integrated models of brain function and the necessity for standardized procedures in EEG biomarker research are highlighted to enhance future research in this field.
Fathers' coping style, antenatal preparation, and experiences of labor and the postpartum.

BACKGROUND In recent years the trend for fathers in Western postindustrial countries to attend childbirth has increased. This study examined the interaction between fathers' information-seeking coping predispositions and their level of attendance at antenatal classes with respect to their experiences of attending childbirth. Associations between fathers' childbirth experiences, their relationship with their baby, and level of depressive symptomatology at 6 weeks postpartum were also examined. METHODS A quantitative methodology was employed in which 78 fathers completed several questionnaires, some within 6 days of childbirth and others at 6 weeks postpartum. RESULTS Fathers who were characterized as high blunters (avoiders) of threat information, from antenatal classes reported that experiencing childbirth was less fulfilling than fathers with similar coping styles who did not attend classes. Fathers' reports of fulfillment and delight while attending childbirth were negatively related to their level of depressive symptomatology at 6 weeks postpartum. Levels of distress were associated with subsequent depressive symptoms, but their effect was removed when preexisting depressive symptoms were partialled out. Fathers whose children were born by cesarean delivery used significantly more negative adjectives to describe their baby at 6 weeks postpartum compared with those born by vaginal delivery. More married fathers attended antenatal classes and reported lower levels of depressive symptomatology than unmarried fathers. CONCLUSIONS Although fathers' attendance at antenatal classes may have positive consequences for them and their partner, for some fathers, attendance at classes may be associated with less positive reports of experiencing childbirth. The way in which men experience childbirth may have some influence on their subsequent emotional well-being.
On the dichotomy in auditory perception between temporal envelope and fine structure cues.

It is important to know what cues the sensory system extracts from natural stimuli and how the brain uses them to form perception. To explore this issue, Smith, Delgutte, and Oxenham [Nature (London) 416, 87–90 (2002)] mixed one sound’s temporal envelope with another sound’s fine temporal structure to produce auditory chimaeras and found that “the perceptual importance of the envelope increases with the number of frequency bands, while that of the fine structure diminishes. ” This study addressed two technical issues related to natural cochlear filtering and artificial filter ringing in the chimaerizing algorithm. In addition, this study found that the dichotomy in auditory perception revealed by auditory chimaeras is an epiphenomenon of the classic dichotomy between low- and high-frequency processing. Finally, this study found that the temporal envelope determines sound location as long as the interaural level difference cue is present. The present result reinforces the original hypothesis that the tempor.
Instability of Superoxide Dismutase 1 of Drosophila in Mutants Deficient for Its Cognate Copper Chaperone*S⃞

Copper,zinc superoxide dismutase (SOD1) in mammals is activated principally via a copper chaperone (CCS) and to a lesser degree by a CCS-independent pathway of unknown nature. In this study, we have characterized the requirement for CCS in activating SOD1 from Drosophila. A CCS-null mutant (Ccsn29E) of Drosophila was created and found to phenotypically resemble Drosophila SOD1-null mutants in terms of reduced adult life span, hypersensitivity to oxidative stress, and loss of cytosolic aconitase activity. However, the phenotypes of CCS-null flies were less severe, consistent with some CCS-independent activation of Drosophila SOD1 (dSOD1). Yet SOD1 activity was not detectable in Ccsn29E flies, due largely to a striking loss of SOD1 protein. In contrast, human SOD1 expressed in CCS-null flies is robustly active and rescues the deficits in adult life span and sensitivity to oxidative stress. The dependence of dSOD1 on CCS was also observed in a yeast expression system where the dSOD1 polypeptide exhibited unusual instability in CCS-null (ccs1Δ) yeast. The residual dSOD1 polypeptide in ccs1Δ yeast was nevertheless active, consistent with CCS-independent activation. Stability of dSOD1 in ccs1Δ cells was readily restored by expression of either yeast or Drosophila CCS, and this required copper insertion into the enzyme. The yeast expression system also revealed some species specificity for CCS. Yeast SOD1 exhibits preference for yeast CCS over Drosophila CCS, whereas dSOD1 is fully activated with either CCS molecule. Such variation in mechanisms of copper activation of SOD1 could reflect evolutionary responses to unique oxygen and/or copper environments faced by divergent species.
Viability and Function of Platelets Frozen at 2 to 3C per Minute with 4 or 5 Per Cent DMSO and Stored at −80C for 8 Months

Each of 15 healthy male volunteers was treated with 650 mg of aspirin 24 hours before the autologous transfusion of one unit of freeze‐preserved platelets. Freeze‐thaw‐wash recovery values in vitro, viability and function in vivo, and the bleeding time and platelet aggregation response were measured. The platelets were frozen with 4 or 5 per cent dimethylsulfoxide (DMSO) at an overall rate of 2 to 3 C per minute and were stored at −80 C in a mechanical freezer for up to eight months. They were washed by dilution/centrifugation.
Long-Term Stability Estimates and Existence of a Global Attractor in a Finite Element Approximation of the Navier-Stokes Equations with Numerical Subgrid Scale Modeling

Variational multiscale methods lead to stable finite element approximations of the Navier-Stokes equations, both dealing with the indefinite nature of the system (pressure stability) and the velocity stability loss for high Reynolds numbers. These methods enrich the Galerkin formulation with a sub-grid component that is modelled. In fact, the effect of the sub-grid scale on the captured scales has been proved to dissipate the proper amount of energy needed to approximate the correct energy spectrum. Thus, they also act as effective large-eddy simulation turbulence models and allow to compute flows without the need to capture all the scales in the system. In this article, we consider a dynamic sub-grid model that enforces the sub-grid component to be orthogonal to the finite element space in L2 sense.We analyze the long-term behavior of the algorithm, proving the existence of appropriate absorbing sets and a compact global attractor. The improvements with respect to a finite element Galerkin approximation are the long-term estimates for the sub-grid component, that are translated to effective pressure and velocity stability. Thus, the stabilization introduced by the sub-grid model into the finite element problem is not deteriorated for infinite time intervals of computation.
Mechanism of action of Pseudomonas aeruginosa exotoxin Aiadenosine diphosphate-ribosylation of mammalian elongation factor 2 in vitro and in vivo

Previous studies showed that Pseudomonas aeruginosa exotoxin A (PA toxin) catalyzes nicotinamide adenine dinucleotide (NAD)-dependent inhibition of protein synthesis in a rabbit reticulocyte lysate and transfer of radioactivity from [14C]adenine-labeled NAD to a protein having the same molecular weight as elongation factor 2 (EF-2) (B.H.Iglewski and D. Kabat, 1975). Such an inhibited protein-synthesizing lysate was restored to activity by addition of a protein from normal mouse liver which co-purifies with EF-2. In addition, EF-2 activity was almost totally absent in livers of mice which had been injected 24 h earlier with PA toxin. On the contrary, EF-2 concentrations were only partially reduced in other organs and were normal in brains of intoxicated mice. Studies using NAD labeled in various positions show that PA toxin, like fragment A of diphtheria toxin, catalyzes transfer of the adenosine 5'-diphosphate-ribosyl moiety of NAD. Furthermore, reversal occurred when the modified protein was incubated with excess concentrations of PA toxin and nicotinamide, and NAD was identified as a product of the reverse reaction. The protein modification catalyzed either by PA toxin or by fragment A of diphtheria toxin could be reversed by incubation with other toxin. These results support the proposal that these two toxins adenosine 5'-diphosphate-ribosylate and same amino acid of EF-2 in a stereochemically identical fashion. Furthermore, PA toxin inactivates EF-2 in intoxicated mice to an extent which would ultimately result in death.
Substance misuse and serious mental illness: spiritual care.

BACKGROUND People with a dual diagnosis of serious mental illness and substance misuse may be difficult to treat. This article explores how spirituality can be integrated into community care plans of these patients. It highlights the importance of including spirituality in pre- and post-basic-education programmes. CONCLUSION Nursing models that integrate the positivist, existential and spiritual approach to understanding and caring for those with a dual diagnosis should be developed. Nurses could develop support groups along the lines of Alcoholics Anonymous to provide support to this group of clients. The use of complementary therapies by those with a dual diagnosis is an area of possibilities. The challenge is now to integrate spirituality into the already established biopsychosocial approach to caring for those with a dual diagnosis.
A Strategic Analysis of the European Companies in the ICT Sales Channel

The strategic role of Information and Communication Technologies (ICT) is growing in various companies. Small and Medium Enterprises (SMEs) adopt ICT solutions to support their processes and to improve their products and services. Because of SMEs' scarce resources and inadequate ICT competencies, they need support from ICT suppliers in the ICT adoption process. Little attention has been paid to the business models and strategies of ICT suppliers in the academic and professional literature, and SMEs find it difficult to determine the characteristics of available ICT suppliers and to choose the supplier that best responds to their needs and aims. The goal of this paper is to provide a detailed picture of the ICT sales channel and its players in the European market. A classification framework is proposed and eleven different business models are identified. The paper is based on a case study methodology that included 53 semi-standardized interviews with CEOs (Chief Executive Officers) and marketing and communications managers at leading European ICT suppliers coupled with the literature review.
Renal Artery Duplex Ultrasonography as a Screening and Surveillance Tool to Detect Renal Artery Stenosis

Objective. Digital subtraction angiography quantitative vessel analysis (QVA) to assess percent renal arterial stenosis (RAS) is the reference standard. Quantitative vessel analysis is not ideal for screening purposes. Renal artery duplex ultrasonography (RADUS) is a noninvasive method to screen for RAS using well‐known parameters. We investigated the direct correlation between several RADUS parameters and QVA to evaluate the acceptability of RADUS as a RAS screening and surveillance tool. Methods. We performed a multicenter retrospective study. Stenoses were evaluated in all patients with arteriograms and RADUS examinations within 30 days of each other in the span of 1 year. Percent stenosis of each stenotic renal artery segment was calculated digitally with QVA and correlated with the corresponding peak systolic velocity (PSV) and renal‐aortic ratio (RAR) obtained with RADUS. Descriptive statistics and receiver operating characteristic curves were calculated. Correlation of percent stenosis, PSV, and RAR was performed. Sensitivity, specificity, and accuracy of diagnostic cut points for each RADUS parameter were calculated. Results. Sixty‐seven renal arteries were included. Thirty‐three arteries had less than 60% stenosis; 34 had stenosis of 60% or greater. The mean values were PSV, 272.791 cm/s; RAR, 3.716; and angiographic percent stenosis, 51.731%. Receiver operating characteristic curves showed higher accuracy for RAR with stenoses of 60% or greater versus PSV. Conclusions. Renal artery duplex ultrasonographic parameters for 60% or greater RAS correlate well with QVA. For detecting stenosis of 60% or greater, RAR is the most accurate parameter at a threshold of 2.5. Renal‐aortic ratio is more accurate than PSV. Peak systolic velocity may be a useful RADUS alternative parameter for hemodynamically important stenoses in the setting of aortic disease when aortic velocities are less than 40 or greater than 100 cm/s.
The yeast Pmp 3 p has a significant role in plasma membrane organization

Pmp3p-related proteins are highly conserved proteins that exist in bacteria, yeast, nematodes, and plants, whose transcript is regulated in response to abiotic stress such as low temperature or high salinity. Pmp3p was originally identified in S. cerevisiae where it belongs to the SNA (Sensitive to Na) protein family which is composed of four members: Pmp3p/Sna1p, Sna2p, Sna3p, and Sna4p. Deletion of the PMP3 gene confers sensitivity to cytotoxic cations, while removal of the other SNA genes did not lead to clear phenotypic effects. It was long believed that Pmp3p-related proteins may have a common and important role in the modulation of plasma membrane potential and in the regulation of intracellular ion homeostasis. Here we show that several growth phenotypes linked to PMP3 deletion can be modulated by the removal of specific genes involved in sphingolipid synthesis. These genetic interactions, together with lipid binding assays and epifluorescence microscopy, as well as other biochemical experiments, suggest that Pmp3p could be part of a phosphoinositideregulated stress sensor.
MiR-181a mediates Ang II-induced myocardial hypertrophy by mediating autophagy.

OBJECTIVE To investigate the relationship between miR-181a and cardiac hypertrophy and autophagy in rats with myocardial hypertrophy, and whether miR-181a regulates the autophagy through ATG5, thereby participating in the occurrence and development of myocardial hypertrophy. MATERIALS AND METHODS The rat model of myocardial hypertrophy was established via the abdominal aortic coarctation. The expression of miR-181a in cardiac tissues was detected via reverse transcription-polymerase chain reaction (RT-PCR). The expressions of autophagy-related proteins, ATG5 and LC3II/LC3I, in cardiac tissues, were detected via Western blotting (WB). After the primary culture of myocardial cells in rats, they were stimulated via Angiotensin II (Ang II) to observe the effects of autophagy inhibitor 3-methyladenine (3-MA) and overexpression of ATG5 on the expression of hypertrophic genes in myocardial cells, respectively. The expressions of autophagy-related proteins ATG5 and LC3II/LC3I were detected via WB, the autophagic rate was observed via flow cytometry and the changes in autophagic vacuoles of myocardial cells were observed using the transmission electron microscope. The changes in mRNA and protein expressions of ATG in myocardial cells were observed after the overexpression of miR-181a or the inhibition of miR-181a activity. The changes in miR-181a and the expression of hypertrophic genes in myocardial cells after Ang II stimulation were observed via RT-PCR. RESULTS In rats with myocardial hypertrophy, the cardiac autophagy was increased and the expression of miR-181a in hypertrophic myocardium was downregulated. 3-MA inhibited the ATG5-induced autophagy and improved the Ang II-induced myocardial hypertrophy, while the overexpression of ATG5 enhanced the myocardial autophagy and the expression of hypertrophic genes. MiR-181a regulated the ATG5-induced myocardial autophagy, and its downregulation mediated the Ang II-induced myocardial hypertrophy. CONCLUSIONS The enhancement of ATG5-induced myocardial autophagy mediates the Ang II-induced myocardial hypertrophy. ATG5 is the target gene of miR-181a, it can regulate the myocardial autophagy via ATG5, thus mediating the Ang II-induced myocardial hypertrophy.
Relationships between tail biting in pigs and disease lesions and condemnations at slaughter

Two matched case-control studies were performed at an abattoir with a capacity of 780 pigs per hour, each study using the approximately 7000 pigs slaughtered on one day. In the first study, the severity of tail biting and pneumonia were recorded in pigs with bitten or intact tails. In the second study, the tail score, sex, and the presence of pleuritis, externally visible abscesses and trimming were recorded in pigs with bitten or intact tails. In study 1, there was no significant association between the tail score and the percentage of lung tissue affected by lesions typical of enzootic pneumonia, but there was a significant association between the severity of tail biting and the prevalence of lungs with abscesses and/or pleuritic lesions (P<0·0001). In study 2, there were significant associations between the severity of tail biting, and the prevalence of external carcase abscesses and carcase trimming; the carcases of castrated males had evidence of tail biting more frequently than the carcases of females (P<0·05).