Miracle-dz/UniFAR-FTUs huggingface dataset:
Experiencia del INCMNSZ en pacientes adultos con leucemia linfoide aguda. Cohorte 2003-2007 con esquemas de tratamiento Hiper-CVAD y Protocolo 0195

Introduccion: A pesar de los avances en el tratamiento, la leucemia linfoide aguda (LLA) en el adulto es una enfermedad con pobres tasas de supervivencia a largo plazo. Es escasa la informacion en paises en desarrollo respecto de esta enfermedad. Por otro lado, las infecciones son complicaciones frecuentes relacionadas con mortalidad y en algunos estudios no se reporta con precision la incidencia de choque septico en esta poblacion, asi como otros parametros relacionados con morbilidad. Objetivo: Describir las caracteristicas de la poblacion de adultos con LLA, la respuesta a tratamiento, las complicaciones y evaluar posibles factores relacionados con supervivencia. Comparar los resultados de los esquemas de quimioterapia utilizados con otros informes de la literatura. Material y metodos: Estudio de cohorte. Se evaluaron todos los pacientes con diagnostico de LLA en el periodo de septiembre de 2003 a noviembre de 2007. Los esquemas de tratamiento utilizados fueron el protocolo institucional 0195 y el esquema Hiper-CVAD (HCVAD). Resultados: Se registraron 40 pacientes con diagnostico de LLA, 92% era de fenotipo B, y 8% de fenotipo T. La mediana de edad fue de 27 anos. Con mediana de seguimiento de 28.5 meses. El 14% presentaba infiltracion del sistema nervioso central (SNC); 51% tuvo citogenetica evaluable, de los cuales 16.7% presento el cromosoma Filadelfia. Recibieron tratamiento 36 pacientes, 13 el esquema HCVAD y 23 el 0195; la tasa global de remision completa (RC) fue de 78%; 85% para el esquema HCVAD y 74% para 0195. En toda la cohorte, la mortalidad en induccion fue de 2.8%; la mediana de supervivencia libre de enfermedad (SLE) fue de 11.6 meses (IC 95%, 2.5-20.8 meses) y de supervivencia global (SG) de 15 meses (IC 95%, 10.6-19.4 meses). En esta serie, 95% de los casos no recibio profilaxis con antibioticos durante el nadir de quimioterapia y la mortalidad relacionada con el tratamiento fue de 8.4% (2.8% en induccion y 5.6% durante las demas etapas del tratamiento). Las variables asociadas con pobre pronostico para SG fueron hiperleucocitosis, fenotipo T y falta de RC temprana. La toxicidad no hematologica grado 3 y 4 asociada con induccion fue de 17%, y la incidencia de neutropenia grave y fiebre durante induccion fue de 61% y de 11% para choque septico. Conclusiones: Respecto de HCVAD, observamos menor tasa de RC y menores periodos de SLE y SG en comparacion con la serie original. A pesar de la ausencia de profilaxis con antibioticos durante las etapas de mielosupresion, las tasas de mortalidad relacionadas con quimioterapia son similares a las reportadas por otros autores. Palabras clave: Leucemia linfoide aguda, neutropenia grave, hiperCVAD.
Challenges to disclosure of HIV status to perinatally infected children: A study of caregiver perspectives in Pune, India

Abstract Effective guidelines around disclosure of HIV status are lacking and limited data from India reveal low rates of HIV disclosure to perinatally infected children. This study, conducted in Pune, India, attempts to understand the experiences of caregivers of perinatally infected children around the HIV disclosure process. We interviewed 98 caregivers whose children were receiving care at the ART clinic of a large government hospital. Caregivers report that 23% of HIV+ children had been told of their HIV status. Older caregivers had higher odds of disclosure as well as those who were widowed, had limited formal education, and who worked as maids/servants. Older children (14 years+) had higher odds of being disclosed to. Major themes from qualitative data included uncertainty among caregivers about disclosure, concerns about the child's well-being after disclosure, and an overall lack of guidance around disclosure. Significant concerns related to perceived and experienced stigma and discrimination as well as the child's marital future contributed to caregivers' willingness to disclose. There is need for the development and testing of behavioural interventions in India to guide health care workers and caregivers in appropriate disclosure to HIV-infected children, with the ultimate goal of informing national guidelines for pediatric HIV disclosure in resource poor settings.
Effect of Water Stress on the Growth, Nutritional and Biochemical Status of Two Varieties of Pomegranate Seedlings

A pot experiment was carried out during successive seasons of 2015 and 2016 to investigate the effect of water stress on growth, nutritional and biochemical status of two pomegranate seedlings (Early 116 and wonderful) as in Egypt. The experimented seedlings were obtained from cuttings of two pomegranate varieties, namely Early 116 as well as wonderful. One year old pomegranate seedlings were grown in pots filled with sandy soil under greenhouse conditions, where they subjected to four water levels, 100% of field capacity (control), 80%, 60% and 40% of available water. The results indicated that the maximum values of vegetative growth parameters (shoot length, number of sprouted shoots as well as leaf surface area) were obtained when the plants were irrigated with 100 % of field capacity, while the minimum values were recorded at 40 % of available water. Wonderful seedlings gave the highest values of tested growth parameters at all water levels as compared with Early 116 variety. The decrease in irrigation water levels led to increase the hard leaf character, proline content, while leaf succulence grade and relative water content were increased by increasing the given amount of irrigation water in both pomegranate varieties. Although the two tested varieties accumulated high values of proline in their leaves when subjected to water stress (80%, 60% and 40% of available water), but the Wonderful variety accumulated high values of proline content under water stress treatments as compared with Early 166 variety . Therefore, Wonderful variety might be more tolerant to drought than Early 116 variety. The content of some macronutrients (N, P and K %) and micronutrients (Fe, Zn, Mn and Cu mg/kg) in leaves of both varieties were decreased by decreasing irrigation water levels. The highest significant values of some macro and micronutrients were found with control treatment (100 % field capacity), while the lowest values of these nutrients were found at sever water stress (40 % available water). On the other hand, Wonderful seedlings significantly showed a higher content of N, P, K, Fe, Zn, Mn and Cu under all water irrigation treatments than those of Early 116.
Deteksi Plat Nomor Kendaraan Bermotor dengan Segmentasi Gambar

Banyak sistem dengan banyak variasi untuk pengenalan plat di negara lain dan metode. Metode ini digunakan untuk mendeteksi plat kendaraan berdasarkan pada bentuk data gambar. Ini dapat membantu sistem yang lebih besar yang digunakan untuk identifikasi pelat. Input yang digunakan adalah file gambar. Aplikasi akan menunjukkan kepada pengguna input dalam bentuk gambar dan memprosesnya menggunakan segmentasi gambar. Segmentasi gambar akan mengekstraksi objek dari gambar yang tidak akan menggunakan dan membagi gambar menjadi beberapa bagian. Sebelum menemukan pelat, aplikasi akan memproses gambar untuk mendapatkan gambar berkualitas lebih baik dengan banyak cara termasuk RGB dan pemrosesan skala abu-abu, ukuran gambar, perhitungan area, deteksi tepi dan segmentasi. Dan hasilnya akan ditampilkan dalam file juga gambar.
The Geography of Mortgage Lending in Times of FinTech

We analyze how banks’ allocations of mortgage credit across regions change when an online platform enables them to offer to regions where they have no branches, staff or legacy. Unique data from an online platform with offers from different banks to each mortgage application yield three novel findings. First, banks offer more and cheaper credit to borrowers in less competitive offline markets. Second, banks offer more credit to more distant locations, where house prices appear less over-heated, and past price growth is less correlated with that in their existing portfolio. Third, over time offers become more automated, lowering operational costs.
Late-breaking abstract: VX-770, an investigational CFTR potentiator, in subjects with CF and the G551D mutation

Background: Restoring dysfunctional CFTR mediated ion transport is a potential treatment for CF. VX-770, a CFTR potentiator, is designed to increase CFTR ion transport activity. Aims and objectives: This Phase 3 study evaluated the efficacy and safety of VX-770 in subjects with CF who have the G551D mutation on at least one CFTR allele. Methods: A randomized, double-blind, placebo-controlled trial of subjects ≥12 years of age who received oral VX-770 150 mg q12h (n=83) or placebo (n=78) for up to 48 weeks. Results: The mean absolute change from baseline through Week 24 in % predicted FEV 1 (primary endpoint), improved by 10.4% in the VX-770 group, while the placebo group decreased by 0.2% (P 1 (P 1 with VX-770 was evident at Day 15 and maintained through Week 48, at which time the VX-770 group showed an improvement of 10.1% (366 mL change) while the placebo group had a decrease of 0.4% (7 mL change). A 55% reduction in the risk of pulmonary exacerbations (P=0.0012) was observed through 48 weeks with VX-770 treatment. The reduction from baseline in sweat chloride, a biomarker of CFTR activity, was –48.1 mmol/L through Week 48 in the VX-770 group compared to placebo (P Conclusions: VX-770 demonstrated a clinically relevant and statistically significant improvement in pulmonary function and reduction in pulmonary exacerbations and sweat chloride up to 48 weeks of treatment. The safety profile was similar to placebo. Supported by Vertex
Learning from regulatory interventions in healthcare: The Commission for Health Improvement and its clinical governance review process

Purpose – This paper aims to present the findings from research commissioned by the Commission for Health Improvement (CHI), which set out to examine the impact of CHI's clinical governance reviews on NHS trusts in England.Design/methodology/approach – This paper, giving a stratified random sample of 30 NHS trusts, was taken from a set of 75 trusts reviewed by CHI during a period from 2001 to 2003. Documents from these trusts' reviews were analysed. A postal questionnaire was sent to key stakeholders with an involvement or direct interest in each trust's review. Semi‐ structured telephone interviews were held with five to six people from each of four trusts selected as case studies.Findings – In this paper the clinical governance review process was characterized by wide variability in methods, application and effects, in the initial CHI visit and report, and the subsequent NHS trust action plan and SHA progress review. The recommendations made by reviews for change in an NHS trust were often of a nature o.
nutritionDay: An Australian hospital's participation in international benchmarking on malnutrition

Aim: Malnutrition is a significant issue for hospitals worldwide. This project examined malnutrition prevalence and associated factors including meal consumption in an Australian hospital. Methods: The cross-sectional study was undertaken at a private hospital in Brisbane, Australia, for 'nutritionDay in Europe' 2009. Nutritional status (subjective global assessment), demographic, medical condition and intake data were collected from 147 inpatients across five medical specialties. Results: The present study found 19.7% (29) of patients were malnourished (17.7% mild to moderately malnourished, 2% severely malnourished). Unintentional weight loss was reported by 39.5% of patients (58) and 49% of patients (72) reported eating less than normal. There were 41.5% of patients (61) who reported not having their usual appetite, with 46.3% (68) eating half or less of a hospital meal. The likelihood of being malnourished increased 4.0 times (CI 1.4-11.6, P= 0.01) for patients who ate less than normal during the previous week and 15 times (CI 4.2-53.5, P < 0.001) for those patients who reported eating less than one quarter to nearly nothing. The likelihood of being malnourished increased 2.9 (CI 1.1-7.6, P= 0.026) and 4.8 (CI 1.6-14.3, P= 0.005) times for patients consuming less than half of breakfast and dinner respectively. Binary logistic regression modelling found a malnutrition screening tool score of ≥2 and average meal consumption of 50% or less were predictors of malnutrition. Conclusions: The present study provides evidence of the increased likelihood of malnutrition in relation to decreased meal consumption and provides insights for future interventions in the acute care setting. © 2011 The Authors. Nutrition & Dietetics
Spatio-Temporal Infectious Disease Epidemiology based on Point Processes

In this Master’s Thesis, a novel combination of point process models continuous in space-time is proposed for infectious disease data. Modelling is driven by the conditional intensity function, which enables a step towards a regression framework for self-exciting spatio-temporal point processes. The model is an extension of the discrete space additive-multiplicative conditional intensity model proposed by Höhle (2009a), and also borrows from earthquake research, especially from the formulation of the space-time ETAS model in Ogata, Katsura & Tanemura (2003). Estimation is performed by means of full maximum likelihood, which for general point processes in space requires the evaluation of two-dimensional integrals. Therefore, various methods of numerical integration are investigated as a prerequisite for maximum likelihood inference. The particular application of interest is the stochastic modelling of the transmission dynamics of the two most common meningococcal strains observed in Germany in 2002–2008. The application showed that the proposed model and its estimation by the provided thoroughly R implementation are applicable and valuable for the analysis of spatio-temporal infectious disease data.
Electrophysiologic features of childhood Guillain-Barré syndrome in Iran

Abstract Guillain-Barré syndrome (GBS) is classified into acute inflammatory demyelinating polyneuropathy (AIDP), acute motor axonal polyneuropathy (AMAN), and acute motor sensory axonal polyneuropathy (AMSAN), but little is known about the incidence of the subtypes and electrophysiologic changes in Northwest of Iran. The aim of this study is to present the electrophysiologic pattern and incidence of various subtypes of childhood GBS. Electrophysiologic features of 72 children (aged 1–15 years old) were studied prospectively during two years in Tabriz Children Hospital. Electrodiagnostic tests were performed in the first 2 weeks of the disease onset. Motor nerve conduction study was performed on the tibial, peroneal, median, and ulnar nerves. Sensory nerve conduction study was performed on the median and sural nerves, F-waves were also studied on the tibial, median, and ulnar nerves. Compound muscle action potential (CMAP) and sensory nerve action potential (SNAP) amplitudes, distal latencies, nerve conduction velocities and F-wave latencies were measured. In this concern, any conduction block and temporal dispersion were noted. Needle electromyography was performed, motor unit action potential changes, and spontaneous activity were studied. Patients were classified into AIDP, AMAN, and AMSAN on the basis of electrodiagnostic criteria. About half of the patients (47.2%) had AIDP form, 44.4% had AMAN, and 5.6% had AMSAN. Moreover, Fisher variant was observed in 2.8% of the cases. The most common electrophysiologic findings were low amplitude CMAP and abnormal F- waves, i.e. 97.2% and 88.9% respectively. Twelve patients (16.8%) required assisted ventilation, 75% of them had AMAN form of GBS. AMAN form of childhood GBS is relatively common in Iran in comparison to Western countries. Respiratory failure resulting in mechanical ventilation is more probable in this form.
Risk-targeted Hazard Maps for Europe

The design of new structures according to modern seismic regulations requires the definition of a uniform hazard spectrum conditioned on a given return period, and it is assumed that the resulting collapse probability will be equally uniform for all structures, regardless of their structural properties or location. However, the uncertainty in the probabilistic collapse distribution and variability in the slope of the seismic hazard curves lead to a level of risk that is siteand structure-specific, and thus not uniform for all structures across a region. The estimation of risk-targeted hazard maps allows for the definition of a design ground motion that leads to a uniform level of risk nationally, defined according to an acceptable risk threshold and collapse probability distribution. The parameters involved in the definition of the probabilistic distribution of collapse are evaluated herein through the analysis of hundreds of fragility models developed for European buildings. The seismic hazard results recently released under the FP7 European project SHARE are employed to estimate the variation of the annual probability of collapse across Europe, and risk-targeted hazard maps for a fixed annual probability of collapse are calculated. The preliminary results expose large areas where the design ground motion could be significantly altered without compromising the level of acceptable risk. Moreover, this study highlights the areas where additional research is still required in order to establish risk-targeted hazard maps as a reliable and efficient tool for the estimation of design ground motion.
Aspectos fisiológicos do pós-parto na égua e do potro recém nascido

Three hundred and ninety deliveries in Thoroughbred mares were observed from July, 1983 until November, 1992. This study was performed with me aim of determing physiologic parameters regarding the partum itself the puerperium and the foal. It was found that older mares produced heavier foals and placentas. The mare's age didn't influence pregnancy length and the gestation length was not related to the period of conception, the foal's sex or weight. 87.54% of the deliveries happened at night (6:00pm and 7:00am) when environmental activities were at a minimum. The average time for the umbilical cord rupture was 6.2 minutes, suggesting that the placental blood may not be that necessary to the foals' health. The suckling reflex was observed 36 minutes after delivery. The mean time taken to stand was 49 minutes, and the one's which stood within 2:23 hours didn't have adaptation problems. The mean time for the first suckling was 94 minutes, and 60% did it within 2 hours after being born. The elimination of meconium occurred 128 minutes after delivery, 30 minutes after the first suckling. The colts' mean weight was 51.7kg and the filhes weight was 50.4kg. Colts were 100.5cm tall and filhes were 99.4cm tall (p < 0.017). Older mares, until 20 years produced foals as healthy as 6-12 years old mares. They had a healthy endometrium, despite of their heavier placentae. The mean weight of placentae was 5.8kg, which is 11.5% of the foals' mean weight. The expulsion of the placenta happened, in average, 50 minutes after delivery. Mares that delivered the placenta until 4:30 hours after foaling had no fertility problems. Placentae weighing more than 5kg were expelled always in less than 54 minutes. The recognition of placental pathology can not be done based only on weight and delivery. The mean weight of the hippomanes was 71g, and was highly related to the placentae weight (p < 0.002). The mean colostral specific gravity (CSG) was 1.069 and the mean zinc sulphate turbidity (ZST) was higher than the standard. There was a high relationship between CSG and ZST (p < 0.0001).
Frail elderly : identification and disability prevention in primary care

• A submitted manuscript is the version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website. • The final author version and the galley proof are versions of the publication after peer review. • The final published version features the final layout of the paper including the volume, issue and page numbers.
Sérotypes de Papillomavirus Humain à Haut Risque chez les Patientes Séropositives au VIH Présentant des Lésions Intra Épithéliales Cervicales

ABSTRACT INTRODUCTION. Many studies have showed a high risk of HPV persistence and the development of cervical cancer among immuno deficient patients. In the aim to determine serotypes of human papilloma virus (HPV) of high risk among HIV infected women with cervical intra epithelial lesions, we conducted a prospective and analytic the study at Medical Diagnostic center and in Centre Pasteur of Yaounde. METHODOLOGY. We carried out a prospective and analytic study which took 9 months. The study included 112 HIV sexually active infected women. Data of interest were the type of cervical epithelial lesions lesion and its grade and risk factors. RESULTS. The average age was 38,5 years. 66% of the smear tests were inflammatory and 21% were dysplastic. 71% of the dysplastic lesions were of high grade. In this high grade group, the HPV testing was always negative. The only significant risk factor was the low CD4 count. CONCLUSION. In Cameroonian HIV infected women, high grade intra epithelial lesions are associated with HPV serotypes that are not highly aggressive, and that therefore can be missed by the ABOOT test. RESUME INTRODUCTION. De nombreuses etudes ont montre un risque eleve de persistance du HPV et de developpement du cancer du col chez les patientes immunodeprimees Dans le but de determiner les Serotypes HPV a haut risque parmi les femmes seropositives au HIV ayant des lesions intra epitheliales, nous avons entrepris une etude prospective et analytique au laboratoire Medical center et au Centre Pasteur de Yaounde. METHODOLOGIE. Il s`agit d`une etude prospective et analytique qui s`est etalee sur 9 mois. Nous avons inclus 112 patientes seropositives, actives sexuellement. Les variables etudiees etaient le type de lesion et le grade ainsi que les facteurs de risques. RESULTATS. L`âge moyen des patientes etait de 38,5 ans. 66% des frottis etaient inflammatoires ( 66%) et 21% etaient dysplasiques. Chez les 21 patientes ayant une dysplasie cervicale, 15 (71%) presentaient une dysplasie de haut grade H-SIL. Dans ce groupe, le test HPV a ete constamment negatif, et le seul facteur de risque significatif etait le taux bas de CD4. CONCLUSION. Chez les patientes HIV positives, les lesions de haut grade sont dues a des Serotypes HPV peu agressifs, donc non visualises par le test ABOOTT qui ne detecte que les Serotypes a haut risque.