Miracle-dz/UniFAR-FTUs huggingface dataset:
Reconstruction of Chronic Anterior Sternoclavicular Joint Dislocations Using a Palmaris Longus Autograft

Background Sternoclavicular joint (SCJ) injuries are uncommon. A minority of patients with anterior dislocation progress to chronic instability associated with pain and a limitation of activities, and thus surgery should be considered. A retrospective case series of an all anterior reconstruction of the SCJ with autologous palmaris longus is presented. Methods Five consecutive patients underwent SCJ stabilization using a palmaris longus autograft tunnelled through the anterior cortices of the medial clavicle and the manubrium sterni, avoiding posterior dissection of the SCJ and its associated risks. Results Three patients reported a completely stable SCJ after surgery at a mean 28 months postoperatively. One other patient reported improved stability and one reported recurrent instability. All patients had returned to work. The median Oxford Shoulder Score was 42 [interquartile range (IQR) 32 to 42] and the median Rockwood Score was 13 out of 15 (IQR 5 to 14). The median overall subjective satisfaction was 90% and, compared to the contralateral side, median satisfaction was also 90% (IQR 50% to 90%). Discussion The technique is safe and effective for reconstructing chronic anterior SCJ dislocations. The all anterior approach for reconstruction of the SCJ reduces the risk to the structures posterior to the medial clavicle, manubrium sterni or first rib.
Involvement of Fcγ receptor polymorphism in the therapeutic response of idiopathic thrombocytopenic purpura

Clearance of autoantibody‐sensitized platelets through Fcγ receptors on phagocytic cells is one of the main mechanisms of thrombocytopenia in idiopathic thrombocytopenic purpura (ITP). We examined the FcγRIIA‐131R/H and FcγRIIIA‐158V/F polymorphisms in 104 adult chronic ITP patients, and in 59 healthy control subjects using polymerase chain reaction‐based allele‐specific restriction analysis. The frequency of FcγRIIA genotypes (131H/H, H/R, R/R) was not significantly different between patients and controls, and did not correlate with the responsiveness to treatment. In contrast, among FcγRIIIA genotypes, frequency of 158F/F homotype was smaller in ITP (P < 0·05). Furthermore, in FcγRIIIA‐158V/V homotype, the complete remission (CR) rate with medication (treatment with corticosteroid or other immunosuppressive agents) was significantly higher (60%) than that in 158V/F (10%) or 158V/F plus 158F/F, (P < 0·01, P < 0·05). Conversely, the CR rate after splenectomy in 158F/F and 158V/F types (64·3% and 54·6%) was higher than in 158V/V (25%). Our results indicate that the polymorphism of FcγRIIIA, but not FcγRIIA, influences the response to treatment in ITP.
GDC-0980 Is a Novel Class I PI3K/mTOR Kinase Inhibitor with Robust Activity in Cancer Models Driven by the PI3K Pathway

Alterations of the phosphoinositide-3 kinase (PI3K)/Akt signaling pathway occur broadly in cancer via multiple mechanisms including mutation of the PIK3CA gene, loss or mutation of phosphatase and tensin homolog (PTEN), and deregulation of mammalian target of rapamycin (mTOR) complexes. The dysregulation of this pathway has been implicated in tumor initiation, cell growth and survival, invasion and angiogenesis, thus, PI3K and mTOR are promising therapeutic targets for cancer. We discovered GDC-0980, a selective, potent, orally bioavailable inhibitor of Class I PI3 kinase and mTOR kinase (TORC1/2) with excellent pharmacokinetic and pharmaceutical properties. GDC-0980 potently inhibits signal transduction downstream of both PI3K and mTOR, as measured by pharmacodynamic (PD) biomarkers, thereby acting upon two key pathway nodes to produce the strongest attainable inhibition of signaling in the pathway. Correspondingly, GDC-0980 was potent across a broad panel of cancer cell lines, with the greatest potency in breast, prostate, and lung cancers and less activity in melanoma and pancreatic cancers, consistent with KRAS and BRAF acting as resistance markers. Treatment of cancer cell lines with GDC-0980 resulted in G1 cell-cycle arrest, and in contrast to mTOR inhibitors, GDC-0980 induced apoptosis in certain cancer cell lines, including those with direct pathway activation via PI3K and PTEN. Low doses of GDC-0980 potently inhibited tumor growth in xenograft models including those with activated PI3K, loss of LKB1 or PTEN, and elicited an exposure-related decrease in PD biomarkers. These preclinical data show that GDC-0980 is a potent and effective dual PI3K/mTOR inhibitor with promise for the clinic. Mol Cancer Ther; 10(12); 2426–36. ©2011 AACR.
Pattern of Motion Restriction in Nigerian Patients with Knee Osteoarthritis

In the Western population, knee osteoarthritis (OA) has been shown to present a characteristic passive motion restriction pattern, called the capsular pattern (extension restriction to flexion restriction ratio ranging from 0.03 to 0.50). The pattern of motion restriction of Nigerian patients with OA has not been previously reported. This study was conducted to determine the pattern of motion restriction in Nigerian patients with knee osteoarthritis. Participants were 50 patients with knee OA (OA Group/OAG), recruited consecutively from two secondary health institutions and 50 age and sex-matched controls (Control Group/CG) without symptoms of OA. Goniometric measurements of passive and active knee motion of participants were taken. Data was analysed using the independent t-test. The OAG, aged 58.1±10.7 years has had OA for 4.0±4.5 years. The CG was aged 55.9±10.3 years. Mean active extension (1.5±5.2°) of the OAG differed significantly (P < 0.05) from that of the CG (0°), but the two groups did not differ significantly in passive extension (OAG = 1.2°±4.4°; CG = 0°). The CG (125.9°±4.6°) had significantly higher (P= 0.0001) active knee flexion than the OAG (99.9°±15.5°). Passive knee flexion of the CG (134.5°±5.0°) was significantly higher (P=0.000) than that of the OAG (110.4°±14.8°). Mean active extension and flexion restriction of OAG was 2.1±5.7° and 26.0±15.4° respectively. Mean passive extension restriction was 1.2±4.4° and passive flexion restriction was 24.0±14.8°, giving a ratio of 0.05 for OAG. Our findings suggest that the passive motion restriction pattern seen in Nigerian patients with knee osteoarthritis is the capsular pattern. KEY WORDS: motion restriction, patients, knee osteoarthritis
Vigilancia de tuberculosis en el Servicio de Salud Viña del Mar-Quillota entre los años 1999-2008: Estudio longitudinal de tendencia

Se evalua la tendencia de las tasas de incidencia de tuberculosis (TBC) y de factores asociados al desenlace de esta enfermedad, en el Servicio de Salud Vina del Mar-Quillota durante los anos 19992008. Estudio de 1.291 pacientes con TBC entre los anos 1999-2008. Se evalua tasa de incidencia y mortalidad por 100.000 habitantes, razon de casos pulmonares/extrapulmonares, presencia de VIH, tasa de letalidad y localizacion de la infeccion. Se observa una tendencia decreciente en la tasa de incidencia (p <0,001; R2 = 0,97) y asociacion entre presencia de VIH y fallecer (p < 0,001). No se observa asociacion entre localizacion de la enfermedad y fallecimiento (p = 0,3), ni tendencia decreciente en la tasa de mortalidad (p = 0,116) ni en la razon de casos pulmonares/extrapulmonares (p = 0,194). La tendencia decreciente de la tasa de incidencia de TBC refleja un buen funcionamiento del sistema de control y vigilancia. La infeccion por VIH se asocia con mayor riesgo de muerte por lo que debe considerarse en el enfrentamiento clinico de la TBC.
Perceptions of Nursing Education Administrators Regarding the Relationship of Admission Criteria to Student Graduation

s International, UMI Number, 3345322 Adelman, C. (2006). The Toolbox Revisited: Paths to Degree Completion from High School through College. Washington, D. C. , U.S. Department of Education. American Association of Colleges of Nursing [AACN] (2009). 2008-2009 Report: Enrollment and Graduation in Baccalaureate and Graduate Programs in Nursing. Retrieved from http://www.aacn. nche.edu/IDS/ Behrman, E. H. , & Street, C. (2005). The validity of using a content-specific reading comprehension test for college placement. Journal of College Reading and Learning. 35 (2), p. 5+. Bluman, A. G. , (2006). Elementary statistics: A step by step approach. New York: McGraw-Hill. Bolan, C. M. , & Grainger, P. (2003). High school to nursing: Given today’s nursing shortage, it is crucial that universities select the nursing school applicants who are most likely to succeed academically. What variables affect progression in the baccalaureate program and help avoid student attrition? The Canadian Nurse, 99 (3), 18+. Buerhaus, P. I. , Auerbach, D. I. , & Stuiger, D. O. (2009, June). The recent surge in nurse
Prevalence of Foot & Mouth Disease in Cattle and Buffaloes in Central Punjab, Pakistan -

An epidemiological investigation conducted in 25 randomly selected villages of the six districts of central Punjab which reported foot and mouth disease. 100 swab samples from buffaloes and cattle were subjected to CFT and then ELISA which determined that FMD serotype “O” was the most prevalent type of antibodies with 67.11%. This was followed by serotype-A with 50.15% and serotype Asia-1 with 39.31%. Statistically significant differences were detected among districts for prevalence of serotypes of FMD. Highest prevalence of FMD serotypes (A, O, Asia-1) were observed in Okara followed by Faisalabad, Multan, Pakpattan, Sahiwal and Khanewal. The high positivity of larger ruminants against FMD serotypes might be due to infectious process or the outbreak wave that comes every year. The effect of the infectious process led to the high production of antibodies in the cattle and buffaloes in the selected districts of Central Punjab. However the role of weekly and monthly livestock markets held every month in Okara and Sahiwal and livestock movements due to sedentary lifestyle of the people and at the eve of Eid ul Azha needs further investigation. Concurrent infections due to all the three serotypes have been confirmed. This suggests to exploring the use of multi-variant vaccine policy for effective control of FMD in the given situation.
Platelet cytochrome c-oxidase activity in patients with acute schizophrenia in the course of their treatment with risperidone

Objectives: Testing a hypothesis, that platelet cytochrome c-oxidase (COX) activities in patients with paranoid schizophrenia, acute episode, may be linked to dynamics of their clinical patterns and quality of cognitive functioning under antipsychotic treatment. Methods: Psychopatho-logical (PANSS, NSA-16) and cognitive assess-ments; platelet COX enzymatic activity determination, post-hoc nonparametric statistical analysis. Results: Psychopathological and cognitive assessments were done and blood was sampled in patients before (at baseline) and after treatment with risperidone. Following regu- larities were found after the treatment of patients: Significant elevation of COX, wherein the higher was COX at baseline, the more prominent was decrease in PANSSneg and NSA rates; significant negative correlation between COX and executive time in cognitive tests. When the patient group was divided by median of COX at baseline into two subgroups (greater or equal median, and 20% was assigned to the first subgroup; significantly larger amount of patients with PANSSneg by <20% was assigned to the second group. Conclusions: Therapy with risperidone seems to be more effective for patients with higher COX activity at baseline, but this fact requires further study.
Patient Characteristics Associated with Medication Adherence

Objective Despite evidence indicating therapeutic benefit for adhering to a prescribed regimen, many patients do not take their medications as prescribed. Non-adherence often leads to morbidity and to higher health care costs. The objective of the study was to assess patient characteristics associated with medication adherence across eight diseases. Design Retrospective data from a repository within an integrated health system was used to identify patients ≥18 years of age with ICD-9-CM codes for primary or secondary diagnoses for any of eight conditions (depression, hypertension, hyperlipidemia, diabetes, asthma or chronic obstructive pulmonary disease, multiple sclerosis, cancer, or osteoporosis). Electronic pharmacy data was then obtained for 128 medications used for treatment. Methods Medication possession ratios (MPR) were calculated for those with one condition and one drug (n=15,334) and then for the total population having any of the eight diseases (n=31,636). The proportion of patients adherent (MPR ≥80%) was summarized by patient and living-area (census) characteristics. Bivariate associations between drug adherence and patient characteristics (age, sex, race, education, and comorbidity) were tested using contingency tables and chi-square tests. Logistic regression analysis examined predictors of adherence from patient and living area characteristics. Results Medication adherence for those with one condition was higher in males, Caucasians, older patients, and those living in areas with higher education rates and higher income. In the total population, adherence increased with lower comorbidity and increased number of medications. Substantial variation in adherence was found by condition with the lowest adherence for diabetes (51%) and asthma (33%). Conclusions The expectation of high adherence due to a covered pharmacy benefit, and to enhanced medication access did not hold. Differences in medication adherence were found across condition and by patient characteristics. Great room for improvement remains, specifically for diabetes and asthma.
MonoPerfCap

We present the first marker-less approach for temporally coherent 3D performance capture of a human with general clothing from monocular video. Our approach reconstructs articulated human skeleton motion as well as medium-scale non-rigid surface deformations in general scenes. Human performance capture is a challenging problem due to the large range of articulation, potentially fast motion, and considerable non-rigid deformations, even from multi-view data. Reconstruction from monocular video alone is drastically more challenging, since strong occlusions and the inherent depth ambiguity lead to a highly ill-posed reconstruction problem. We tackle these challenges by a novel approach that employs sparse 2D and 3D human pose detections from a convolutional neural network using a batch-based pose estimation strategy. Joint recovery of per-batch motion allows us to resolve the ambiguities of the monocular reconstruction problem based on a low-dimensional trajectory subspace. In addition, we propose refinement of the surface geometry based on fully automatically extracted silhouettes to enable medium-scale non-rigid alignment. We demonstrate state-of-the-art performance capture results that enable exciting applications such as video editing and free viewpoint video, previously infeasible from monocular video. Our qualitative and quantitative evaluation demonstrates that our approach significantly outperforms previous monocular methods in terms of accuracy, robustness, and scene complexity that can be handled.
Processes of Care Predict Survival Following Nursing Home-Acquired Pneumonia

residents. • Design: Review and analysis of nursing home records. • Setting and participants: 135 incidents of NHAP among 2251 random Medicare nursing home admissions to 58 skilled nursing facilities located in 5 states during 1997. • Methods: Management of NHAP episodes occurring during the 90 days following nursing home admission was evaluated using explicit criteria. The criteria were developed by a multidisciplinary panel using a modified Delphi approach and included appropriate timing and thoroughness of nurse and physician evaluation; hospitalization; and timing, route, duration, and spectrum of antibiotics. Criteria were summed to create an episode score. The association between 30-day survival, individual criteria, and the episode score was assessed, adjusting for case mix using multivariate methods. • Results: For 67% of episodes, contact between the home and physician occurred within one 8-hour shift of symptoms being noted. 47% of patients for whom antibiotics were ordered (n = 98) received them within 16 hours, and 43% received antibiotics for 10 to 14 days. Patients treated with antibiotics covering S. pneumoniae, H. influenzae, and either gramnegative rods or S. aureus (75%) were more likely to survive (odds ratio [OR], 5.82 [confidence interval {CI}, 1.72‐19.7]). There was a trend toward improved survival when hospitalization was appropriate (OR, 2.25 [CI, 0.93‐5.44]). Patients who survived had a higher episode score (4.2 of 7 measures) than those who died (3.2 measures, P = 0.001). This difference remained significant after case-mix adjustment. • Conclusion: Appropriate care for NHAP, based on explicit criteria defined by a multispecialty panel, was associated with improved survival.
Technology Acceptance of the Lonely Planet Website: An Exploratory Study

This study aims at examining the reasons that motivate travelers to use online travel websites for travel information search and reservations by adapting technology acceptance model (TAM). In particular it examines the site of an online travel guide (lonelyplanet.com). The results suggest that perceived usefulness determines behavioral intention to use the travel website. Perceived ease of use does not have a direct impact on behavioral intention; however, it influences perceived usefulness and behavioral intention indirectly. This study benefits practitioners in the preimplementation stage to overcome complaints that system characteristics are arbitrary or in the postimplementation stage to determine the kinds of changes that provide the most meaningful impacts.
Is There an Advantage Over SF-36 with a Quality of Life Measure That Is Specific to Systemic Lupus Erythematosus?

Objective. To assess whether the Lupus Quality of Life (LupusQoL) questionnaire contributed additional information not obtained using the Medical Outcomes Study Short-Form 36 questionnaire (SF-36) in a cohort of patients with systemic lupus erythematosus (SLE). Methods. Forty-one patients seen at a single center were followed at monthly intervals for 12 months. The LupusQoL and the SF-36 questionnaires were coadministered monthly. Disease activity was determined by the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) every 30 days. We determined the correlation of the 4 comparable domains of both questionnaires. For the 4 noncomparable domains of the LupusQoL we determined the correlation between each domain with the Physical Component Summary scores (PCS) and the Mental Component Summary scores (MCS) of the SF-36. The effect size (ES) and the standardized response mean (SRM) were used to compare the responsiveness of both questionnaires when a clinically significant change in disease activity occurred as determined by SLEDAI-2K. Results. Three hundred seventy-six patient visits were recorded. There was a strong correlation between comparable domains in both questionnaires. For the 4 noncomparable domains of the LupusQoL, there was a correlation with the MCS and PCS of SF-36. The mean scores for comparable domains in both questionnaires were similar. Both questionnaires displayed responsiveness, as determined by ES and SRM among patients who flared and improved, but not among patients in remission, when compared to the previous visit. Conclusion. LupusQoL and SF-36 were equivalent in assessing quality of life over time in this group of patients. Both questionnaires are responsive measures of quality of life in patients with SLE flares and improvement.
Genome‐Wide Association Mapping Reveals Novel QTL for Seedling Leaf Rust Resistance in a Worldwide Collection of Winter Wheat

The association panel used in this study may represent the largest in wheat GWAS Three pathotypes, including a bulked races collected in the field, were used A total of 14 QTL for leaf rust resistance were identified at a FDR of 0.01. Six QTL identified in this study are novel loci in bread wheat Thirty‐one additional QTL were significant at a FDR of 0.05.
Delivering an infection control link nurse programme: improving practice

This is the second in a series of articles describing a research study that examined the efficacy of an infection control link nurse programme, which had an educational programme based upon adult learning theory, delivered using an action research approach. This article describes the results of a quantitative study that aimed to identify if the utilisation of this programme led to improvements in infection control practice at clinical level. Implications for practice are discussed.
Newly entered medical students’ views on an Information Communication Technology course

Even though Information and Communication Technology (ICT) has a relatively short history, it has become a part of the medical industry, not only in selected areas of high technology medicine, but throughout the industry. Apart from using IT for medical education, it has become a mandatory element in modern medical and surgical practice. Therefore, an ICT course was designed for the new entrants of the Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka and the perception of students on the course was evaluated using a validated questionnaire. The results of this study confirmed that the course was well organised and interesting but the time allocated for the course needs to be increased. Sri Lanka Journal of Bio-Medical Informatics 2012; 3 (3): 97-100 DOI: http://dx.doi. org/10.4038/sljbmi.v3i3. 5280
Health Care for American Indian Elders: An Overview of Cultural Influences and Policy Issues

Changing demography (people living longer and large cohorts aging) is a global phenomenon. American Indians are among the transitional groups with the proportion of elderly expected to double in the next 50 years. The excess burden of illness and health-status disparities between American Indians and the general population are well documented and have consequences affecting health status and functional abilities of American Indians. Health problems and functional limitations intensify the need for home- or community-based long-term-care services among older American Indians. Important considerations in providing these services include understanding historical and cultural influences on their family life, role expectations across generations, and aging as part of human development in contemporary life. In addition, poverty and changing federal policies influence how elders view health and health care delivery on reservations. This article provides an overview of the cultural influences and policy issues related to health care for American Indian elders on reservations.
Inspection Visits in Residential Care Facilities for the Elderly

This study investigated the effects of a policy change in California that decreased annual state inspections of residential care facilities for the elderly to once every 5 years. Data collection involved a 5-year retrospective review of public facility files. Files were obtained from a probability sample of 340 licensed facilities, stratified by facility size and district office. Generalized estimating equations were used for multivariate analyses of size, office, and period effects of types of visits made and citations relative to quality of care. Routine survey visits were replaced with increases in the number of complaint- or problem-driven visits. Rates of quality of care citations arising from complaints or problems increased. Practice patterns among offices and variations by facility size were identified. Data from the resulting process affect comparisons of the industry and facility trends regarding quality of care. The problem-driven system may affect the rate of proactive consultation and quality-improvement visits.