Miracle-dz/UniFAR-FTUs huggingface dataset:
RBC‐choline: changes by lithium and relation to prophylactic response

ABSTRACT– Red blod cell (RBC)‐ and plasma‐choline levels were measured in patients on lithium (n= 96), antidepressants (n ‐ 32) and nenroleptics (n= 51), and in 25 healthy drug‐free controls. Lithium patients exhibited highly increased RBC‐ and slightly increased plasma‐choline levels compared with controls (P < 0.001 and P < 0.05, respectively); the choline ratio (RBC‐/plasma‐choline) was elevated almost to the same extent as RBC‐choline (P < 0.001). With antidepressants RBC‐choline and choline ratios were slightly reduced (P < 0.05), whereas neuroleptics showed no effect on choline levels. 79 % of lithium patients were responders (reduction in hospitalizations with lithium), 21 % were non‐responders (no reduction or increase in hospitalizations]. Choline ratio exhibited a significant relation to prophylactic lithium response, but lithium ratio did not. The percentage of nori‐responders was significantly higher in patients with a choline ratio exceeding 100 than in patients with a choline ratio below this cut‐off (P < 0.01). Thus, the increase of RBC‐choline and choline ratios appears to be an effect specific for lithium and might be related to the outcome of lithium prophylaxis.
Is the Identification of SNP-miRNA Interactions Supporting the Prediction of Human Lymphocyte Transcriptional Radiation Responses?

Genome-Wide Association Studies (GWAS) are of great importance in identifying the genetic variants associated with traits/diseases. Due to the high number of candidate SNPs some filtering techniques are necessary to be applied. The aim of the study was to develop the comprehensive approach allowing for detailed analysis of both SNP-gene and SNP-miRNA-gene relations. We elaborated and optimized the novel signal analysis pipeline improving significantly the results of the analysis on genotype-phenotype interplay. Direct links between genotype results and gene expression levels were enriched by detailed analysis of SNP-miRNA-gene interactions at both mature miRNA structure/seed region and target binding site level. The proposed technique was applied to the data on lymphocyte radiation response and increased by almost 100% number of potential
Atrioventricular dissociation in acute rheumatic fever.

Enhanced nodal pacemaker activity, manifested in the electrocardiogram as atrioventricular dissociation, appeared in 20 per cent of an unselected group ofyoung adults with acute rheumatic fever. Though the arrhythmia seemed to reflect myocardial involvement by the rheumatic process, it did not correlate with the clinical diagnosis of 'carditis', and its presence had not the prognostic and therapeutic implications of this condition. The arrhythmia may be found to be of considerable value in the diagnosis of acute rheumatic fever. However, more material should be collected to substantiate this assumption.
Cryopreservation of the mammalian kidney. II. Demonstration of immediate ex vivo function after introduction and removal of 7.5 M cryoprotectant.

The objective of the present study was to determine whether rabbit kidneys could be perfused with a 7.5 M vitrification solution (VS4, which vitrifies under applied pressure) without loss of function. To answer this question, kidneys were perfused with VS4 using a computer-based machine to gradually raise and lower concentration and then attached to the aorta and vena cava of a perfusor rabbit using an apparatus that permitted renal blood flow and renal function to be measured. About half (6/13) of the kidneys so evaluated resumed substantial immediate function after a transient period of severely reduced blood flow. Loss of function did not occur if cryoprotectant concentration was limited to 3.8 M. The loss of function produced by VS4 could be partially reproduced by artificially limiting blood reflow in control kidneys to simulate the transiently low flows caused by VS4 exposure. These results provide the first evidence that both the parenchyma and the vascular system of a sensitive mammalian organ can survive exposure to a vitrifiable concentration of cryoprotectant.
Metabolic syndrome exacerbates short-term postoperative cognitive dysfunction in patients undergoing cardiac surgery: results of a pilot study.

OBJECTIVE The authors tested the hypothesis that patients with metabolic syndrome are more likely to develop short-term cognitive dysfunction after cardiac surgery with cardiopulmonary bypass. DESIGN A prospective study. SETTING Veterans Affairs medical center. PARTICIPANTS Fifty-six age- and education-balanced patients undergoing elective cardiac surgery with cardiopulmonary bypass (28 patients with and without metabolic syndrome in two separate groups) and 28 nonsurgical controls were enrolled. INTERVENTIONS None. MEASUREMENTS AND MAIN RESULTS Recent verbal and nonverbal memory and executive functions were assessed using a psychometric test battery before and 1 week after cardiac surgery or at 1-week intervals in nonsurgical controls. Neurocognitive scores under the baseline condition were at least 1 z score (1 standard deviation) worse in surgical patients with compared without metabolic syndrome in all 3 cognitive areas (nonverbal and verbal recent memory and executive functions). Neurocognitive performance further deteriorated after surgery by at least 1 z score on 3 tests in the verbal memory modality (Immediate and Delayed Story Recall and Delayed Word List Recall). Overall cognitive performance (composite z score) after surgery was significantly (p = 0.03) worse in metabolic syndrome patients compared with those who did not have the disorder. CONCLUSIONS The results indicate that short-term cognitive functions were more profoundly impaired in patients with metabolic syndrome undergoing cardiac surgery with cardiopulmonary bypass compared with their healthier counterparts.
Exploring behavioural branding, brand love and brand co-creation

This paper aims to contribute to the understanding of the complex consumer brand relationships by holistically exploring the dynamics between brand love and co-creation, how they are impacted by behavioural branding and their combined impact to brand loyalty. ,This is a conceptual paper, based on extensive and thorough literature review on the fields of brand love, behavioural branding, brand communities and co-creation, that leads to the formulation of a proposed synthesized framework. ,The authors propose that consumers experiencing brand love are more willing to engage in an active co-creating behaviour in the context of a brand community, especially when brand representatives vividly communicate the brand values and motivate consumers to engage. This process is moderated by the product/service category and level of customer involvement with it, and it produces a combined positive impact on brand loyalty. ,The proposed conceptual framework needs to be validated through empirical research. However, even at this initial stage, it may have a significant impact, especially as it highlights the role of brand representatives and how they could drastically moderate the relationship between the brand and the consumer. ,This is the first attempt to incorporate the constructs that are significant to the consumer–brand relationship research stream in one conceptual framework. The synthesis of these concepts will contribute to the improved understanding of the consumer–brand relationship, and its dynamics and will equip managers with a novel approach to the central role of behavioural branding.
The occurrence of congeneric trematode species in Lymnaea emarginata from Lake Ainslie, Cape Breton.

A survey of larval trematodes in Lymnaea emarginata from Lake Ainslie, Cape Breton Island, showed the presence of 10 species. The two most abundant species were congeneric, with very similar life cycles: Plagiorchis muris and P. proximus. These two species never occurred together in large numbers at the same time, but showed both temporal succession and spatial isolation.The general level of parasitism was found to increase with increased size of adult snails, but juvenile snails were never found infected during the summer months.
Actinomycin D as a Probe for Nucleic Acid Secondary Structure

The binding of actinomycin D to DNA results in an increase in the temperature at which thermal dissociation of the DNA occurs. With this enhancement of thermal stability as a criterion for binding, it is shown that complementary RNA and DNA-RNA hybrid do not bind actinomycin D. This result can be interpreted to mean that these polynucleotides have helical conformations which differ from that of DNA.
ANTECEDENTS OF JOB SATISFACTION A CASE STUDY OF HOSPITAL'S EMPLOYEES OF PAKISTAN

In competitive world under pressure of work, job satisfaction plays vital role for success and it is one of the major issues in developing country like Pakistan. This study focuses on the hospital employee’s perception towards job satisfaction. In this regard the associations of factors like Pay & Benefits, Career Development & Management, Supervision & Collegiality and Participation (dependent variables) with Job Satisfaction (independent variable) of the employees working in the Hospitals of Pakistan have been examined. To collect data, questionnaire survey was used and 162 employee responses from survey. The respondents included Medical and Non-medical employees. The result shows positive correlation between the dependent and independent variable. The relation between Participation and Job Satisfaction was the most significant, indicating that an employee who participates more can yield maximum Job Satisfaction. Pay & Benefits, Career Development & Management and
The Relationship between Judicial Staff and Court Performance: Evidence from Brazilian State Courts

To handle increasing caseloads, the judicial systems of several countries have adopted three main strategies: developing new standards and judicial procedures; investing in information and communication technologies; and hiring additional judicial staff. This paper investigates the impact of this third strategy on the performance of Brazilian courts. We use multiple regression analysis to test an array of related hypotheses about the complex interactions between the number of judicial staff and court productivity. The empirical research uses ten-year (2003-2012) data from 27 Brazilian courts. The main findings indicate that the number of judicial assistants has a positive influence on court productivity, and the number of assistants mitigates the positive relationship between court caseload and court productivity. The results are discussed and further studies are suggested.
Routine Use of Screening and Brief Intervention for College Students in a University Counseling Center

Abstract This study provides preliminary evidence of the effectiveness of the Alcohol, Smoking, and Substance Involvement Screening Test (ASSIST) and ASSIST-linked brief intervention in a college mental health clinic. Data are from a single group, pre-post evaluation study (2006–2009) at a university counseling center. Students deemed to be at risk for substance use problems were offered the ASSIST and the ASSIST-linked brief intervention. Staff therapists administered the ASSIST and intervention as part of routine care; 453 students (ages 18–24) participated in the evaluation and completed baseline and six-month follow-up interviews. Changes in alcohol and marijuana use were examined by McNemar's test of proportions and by paired t-tests for means. Slight reductions in the rates and number of days (in the prior 30 days) of binge drinking and marijuana use were found. Routine screening and brief intervention procedures in a mental health setting may reduce problematic substance use among college students.
A single‐arm, multicenter, open‐label phase 2 study of lapatinib as the second‐line treatment of patients with locally advanced or metastatic transitional cell carcinoma

The treatment of recurrent transitional cell carcinoma (TCC) remains an unmet clinical need. This study assessed lapatinib, a dual tyrosine kinase inhibitor of epidermal growth factor receptor (EGFR) and HER‐2, as second‐line therapy in patients with locally advanced or metastatic TCC.
Inmate Thinking Patterns

This study investigated patterns of maladaptive thinking in 435 offenders and sought to develop and preliminarily validate a measure of criminal thinking patterns. An exploratory factor analysis of 77 thinking errors derived from four theories of cognitive distortions that influence behavior yielded a three-factor model of dysfunctional thinking among offenders. Interpretations of these three factors were provided (i.e., Control, Cognitive Immaturity, and Egocentrism). Implications for treatment and future research with offenders, using the conceptualization of erroneous thinking posited by the three-factor model, are discussed.
FAMILY CONTROL, AUDITOR INDEPENDENCE, AND AUDIT QUALITY: EMPIRICAL EVIDENCE FROM THE TSE-LISTED FIRMS (1999-2002)

The present study posits that auditors have weaker bargaining power when facing clients with ultimately controlling family members as opposed to clients without. By analyzing clients’ magnitude of discretionary accruals in company with audit reports, the present study examines empirically the influence of family-controlled clients on the audit quality. The empirical results, as expected, reveal that the magnitude of discretionary accruals of a family-controlled firm, given receiving a standard unqualified audit report, is significantly larger than a firm that has no ultimately controlling family members. Moreover, family-controlled firms with larger positive discretionary accruals, as expected, are more likely to receive a standard unqualified audit report than clients without ultimately controlling shareholders. The above empirical results suggest that the audit quality is indeed deteriorated when an auditor faces a family-controlled client.
Incidence and Mortality of Breast Cancer and their Relationship to Development in Asia.

PURPOSE This study aimed to investigate the incidence and mortality of breast cancer, and its relationship with human development index (HDI) and its components in Asia in 2012. MATERIALS AND METHODS This study was an ecologic study in Asia for assessment of the correlation between age-specific incidence rate (ASIR) and age-specific mortality rate (ASMR) with HDI and its details that include: life expectancy at birth, mean years of schooling and gross national income (GNI) per capita. Data about SIR and SMR for every Asian country for the year 2012 were obtained from the global cancer project. We used a bivariate method for assessment of the correlation between SIR and SMR and HDI and its individual components. Statistical significance was assumed if P<0.05. All reported P-values are two-sided. Statistical analyses were performed using SPSS (Version 15.0, SPSS Inc.). RESULTS In 2012, 639,824 cases of breast cancer were recorded in Asian countries. Countries with the highest standardized incidence rate (ASIR) (per 100,000) were Israel (80.5), Lebanon (78.7), Armenia (74.1) and the highest standard mortality rate (ASMR) was observed in Pakistan (25.2), Armenia (24.2), and Lebanon (24). There was a positive correlation between the ASIR of breast cancer and HDI (r = 0.556, p <0.001), whereas there was a negative correlation between the ASMR of breast cancer and HDI (r = -0.051). CONCLUSIONS Breast cancer incidence in countries with higher development is greater, while mortality is greatest in countries with less development. There was a positive and significant relationship between the ASIR of breast cancer and HDI and its components. Also there was a negative but non significant relationship between the ASMR of breast cancer and HDI.
PRAKTIK MANAJEMEN RANTAI PASOK DAN TEKNOLOGI BISNIS BERBASIS ELEKTRONIK SEBAGAI PEMODERASI PERUSAHAAN MANUFAKTUR

This research develops and tests the consistencies of the relation between supply chain management practices, e-business technologies and operational performance. The data for this research is obtained from 67 companies. The relations proposed in the framework of this research are tested using partial least square analysis. The findings of this research shows the impact of supply chain management practices and e-business technologies have an effect on improvement of operational performance. The analysis also found the existence of interaction effect between SCM practices and e-business technologies, both on operational performance.
ESTIMATING THE PROBABILITY OF SERVICE RECOVERY STRATEGIES IN FRANCHISE FAST FOOD RESTAURANT

This paper sets out to determine the probability from a customerâ€™s viewpoint, of which service recovery activities will most probably be carried out by front liners in Franchise Fast Food Restaurants (FFFR). The study utilized a Juster scale based questionnaire survey format. Data was then analyzed using means and factor analysis. Means analysis indicated that customers did not expect front liners to offer free food but there was a good possibility that they would receive an apology. More than half of the service recovery strategies studied lay below the 50/50 probability. Factor analysis indicated three views of customers on service recover strategies, which are termed as â€˜Immediateâ€™, â€˜Worksâ€™ and â€˜Wordsâ€™. Customers believe that there is a good possibility for â€˜Wordsâ€™ service recovery activity, fairly good possibility of â€˜Immediateâ€™ service recovery and fair possibility of â€˜Worksâ€™ service recovery activity. The study was limited to respondents in Kuching and customers of FFFR. Nevertheless the finding has important implications to management and academia. A practical application from this study would be the use of â€˜Immediateâ€™ and â€˜Wordsâ€™ service recovery strategies to improve customerâ€™s perception of a company after service failure. The use of â€˜Worksâ€™ would delight them, as it is not expected.
Gregariousness, interactive jobs and wages

Gregariousness and social interaction are important aspect of human life with implications also for labour markets. To the best of our knowledge, this paper is the first to examine gregariousness and social interaction at the workplace and associated wages for Germany. Our empirical findings with samples from the German Socio-Economic Panel (SOEP) demonstrate that extravert people more often work in jobs with more social interaction. Furthermore, females tend to work more often in interactive jobs compared to males. There is evidence that gregariousness and social interaction are associated with (moderately) higher wages, except when high interaction occurs in large firms.ZusammenfassungGeselligkeit und soziale Interaktion sind wichtige Dimensionen menschlichen Daseins, deren Konsequenzen für die Verteilung der beruflichen Tätigkeiten und der Löhne noch wenig erforscht sind. In dieser Studie werden daher, unseres Wissens erstmals für Deutschland, die Bedeutung von Geselligkeit und soziale Interaktion in der beruflichen Tätigkeit sowie für damit einhergehende Lohnunterschiede untersucht. Der empirische Teil der Studie basiert auf Stichproben aus dem Sozio-Ökonomischen Panel (SOEP). Die Ergebnisse deuten darauf hin, dass Geselligkeit die Wahrscheinlichkeit erhöht, in einem Beruf mit sozialer Interaktion tätig zu sein. Zudem sind Frauen häufiger in Berufen mit mehr sozialer Interaktion tätig. Die Regressionsergebnisse deuten darauf hin, dass Geselligkeit und eine Tätigkeit in einem beruflichen Umfeld mit einem hohen Maß an sozialer Interaktion mit (moderat) höheren Löhnen einhergehen.
Fracture Control of Ground Water Flow and Water Chemistry in a Rock Aquitard

There are few studies on the hydrogeology of sedimentary rock aquitards although they are important controls in regional ground water flow systems. We formulate and test a three‐dimensional (3D) conceptual model of ground water flow and hydrochemistry in a fractured sedimentary rock aquitard to show that flow dynamics within the aquitard are more complex than previously believed. Similar conceptual models, based on regional observations and recently emerging principles of mechanical stratigraphy in heterogeneous sedimentary rocks, have previously been applied only to aquifers, but we show that they are potentially applicable to aquitards. The major elements of this conceptual model, which is based on detailed information from two sites in the Maquoketa Formation in southeastern Wisconsin, include orders of magnitude contrast between hydraulic diffusivity (K/Ss) of fractured zones and relatively intact aquitard rock matrix, laterally extensive bedding‐plane fracture zones extending over distances of over 10 km, very low vertical hydraulic conductivity of thick shale‐rich intervals of the aquitard, and a vertical hydraulic head profile controlled by a lateral boundary at the aquitard subcrop, where numerous surface water bodies dominate the shallow aquifer system. Results from a 3D numerical flow model based on this conceptual model are consistent with field observations, which did not fit the typical conceptual model of strictly vertical flow through an aquitard. The 3D flow through an aquitard has implications for predicting ground water flow and for planning and protecting water supplies.
Changes in Patient-Reported Alcohol-Related Advice Following Veterans Health Administration Implementation of Brief Alcohol Interventions.

OBJECTIVE Brief alcohol interventions are recommended for primary care patients who screen positive for alcohol misuse, but implementation is challenging. The U.S. Veterans Health Administration (Veterans Affairs [VA]) implemented brief interventions for patients with alcohol misuse in 2008, and rates of brief interventions documented in the electronic medical record increased from 24% to 78% (2008-2011). This study examined whether an independent measure of brief interventions-patient-reported alcohol-related advice-also increased among VA outpatients who screened positive for alcohol misuse on a mailed survey. METHOD This retrospective cross-sectional study included VA outpatient respondents to the VA's Survey of Healthcare Experiences of Patients (SHEP; 2007-2011) who reported past-year alcohol use and answered a question about alcohol-related advice. Alcohol-related advice was defined as a report of past-year advice from a VA clinician to abstain from or reduce drinking. The adjusted prevalence of alcoholrelated advice among patients who screened positive for alcohol misuse (SHEP AUDIT-C ≥ 5) was estimated for each year. RESULTS Among patients with alcohol misuse (n = 61,843), the adjusted prevalence of alcohol-related advice increased from 40.4% (95% CI [39.3%, 41.5%]) in 2007 to 55.5% (95% CI [53.3%, 57.8%]) in 2011. Rates of alcoholrelated advice increased significantly each year except the last. CONCLUSIONS The VA's efforts to implement brief interventions were associated with increased patient-reported alcohol-related advice over time, with a majority of patients with alcohol misuse reporting its receipt. Other systems considering similar approaches to implementation may benefit from collecting patient-reported measures of brief interventions for an additional perspective on implementation.