Miracle-dz/UniFAR-FTUs huggingface dataset:
Determining the Pain-Affecting Factors of University Students with Nonspecific Low Back Pain

[Purpose] This study was conducted on university students with nonspecific low back pain in order to determine the independent variables that affect their pain. [Methods] A total of 514 students were included in this study. Pain was evaluated using a Visual Analogue Scale (VAS). A special form was prepared in order to evaluate the following independent variables: gender, weight, height, Body Mass Index (BMI), working periods sitting straight (television, computer, seminar, etc.), working periods bending at a table (reading, writing, etc.), using lumbar support while sitting, the mean duration of pain within the last one year, type of pain, time of the pain, faculty, class, physical activity habits and smoking. The collected data were evaluated using the CHAID (Chi-squared Automatic Interaction Detection) analysis method. [Results] The working hours bending at a table, physical activity, height, weight, BMI and educational departments were found not to affect the severity of the pain. The pain severity was affected by the duration of pain complaints within the last one year, the duration of working staying upright, smoking, classes, usage of lumbar support and age variables. [Conclusions] The results of this study show that nonspecific low back pain of university students is affected by many factors such as smoking, class, age, using a computer and lumbar support.
Similar Outcome After Unrelated Allogeneic Peripheral Blood Stem Cell Transplantation Compared With Bone Marrow in Children and Adolescents

This study compares children and adolescents with hematological malignancies undergoing allogeneic stem cell transplantation (ASCT) with unrelated donors receiving either bone marrow (BM, n=39) or peripheral blood stem cells (PBSCs, n=35). Age and other characteristics were comparable in the two groups. All patients were given conventional conditioning and antithymocyte globulin (ATG). Graft-versus-host disease prophylaxis consisted of cyclosporine plus methotrexate or prednisolone. After PBSC, engraftment of neutrophils and platelets were more rapid. The incidences of acute and chronic graft-versus-host disease were similar in the two groups. In the two groups, other outcome variables, such as transplant-related mortality, overall survival, and relapse-free survival, were the same. Patients given BM tended to have more relapses (P=0.1) and patients given PBSC tended to have more incidences of infectious death. Four cases of EBV-lymphomas were found among patients receiving PBSC, whereas no case was seen in patients given BM (P=0.1). We found no differences in transplant-related mortality and survival in children and adolescents receiving BM or PBSC from unrelated donors. More rapid engraftment and a trend for less relapses in patients given PBSC grafts was noted.
Association of the Human Papillomavirus Type 11 E1 Protein with Histone H1

ABSTRACT The E1 and E2 proteins are the only virus-encoded factors required for human papillomavirus (HPV) DNA replication. The E1 protein is a DNA helicase responsible for initiation of DNA replication at the viral origin. Its recruitment to the origin is facilitated by binding to E2, for which specific recognition elements are located at the origin. The remaining replication functions for the virus, provided by the host cell’s replication machinery, may be mediated by further interactions with E1 and E2. Histone H1 was identified as an HPV type 11 (HPV-11) E1-binding protein by far-Western blotting and by microsequence analyses of a 34-kDa protein purified by E1 affinity chromatography. E1 also bound in vitro to H1 isolated under native conditions in association with intact nucleosomes. In addition, E1 and H1 were coimmunoprecipitated by an E1 antiserum from a nuclear extract prepared from cells expressing recombinant E1. Bound H1 was displaced from HPV-11 DNA by the addition of E1, suggesting that E1 can promote replication initiation and elongation by alteration of viral chromatin structure and disruption of nucleosomes at the replication fork. Furthermore, a region of the HPV-11 genome containing the origin of replication was identified which had weaker affinity for H1 than that of the remaining genome. This result suggests that the presence of a DNA structure at or near the HPV origin facilitates initiation of DNA replication by exclusion of H1. These results are similar to those of studies of simian virus 40 DNA replication, in which a large T antigen-H1 interaction and an H1-resistant region at the origin of DNA replication have also been demonstrated.
A Standardized Method of Diplomatically and Effectively Reporting Child Abuse to State Authorities

Although many studies have examined issues relevant to reporting child maltreatment to state authorities, empirical evaluation of intervention programs to assist professionals in reporting child abuse is lacking. In the present study, a medical student was taught to perform a standardized behavioral method of reporting child abuse that incorporates nonperpetrating caregivers of child abuse victims in the reporting process. A controlled multiple baseline across behaviors (i.e., initiating child abuse report, responding to upset) experimental design was utilized to evaluate skills acquisition. Improvements in interpersonal skills related to reporting child abuse were demonstrated consequent to intervention. Future directions are discussed in light of these results.
The dynamics of imprinted X inactivation during preimplantation development in mice

In the mouse, there are two forms of X chromosome inactivation (XCI), random XCI in the fetus and imprinted paternal XCI, which is limited to the extraembryonic tissues. While the mechanism of random XCI has been studied extensively using the in vitro XX ES cell differentiation system, imprinted XCI during early embryonic development has been less well characterized. Recent studies of early embryos have reported unexpected findings for the paternal X chromosome (Xp). Imprinted XCI may not be linked to meiotic silencing in the male germ line but rather to the imprinted status of the Xist gene. Furthermore, the Xp becomes inactivated in all cells of cleavage-stage embryos and then reactivated in the cells of the inner cell mass (ICM) that form the epiblast, where random XCI ensues.
Genetic and Environmental Influences on Recurrent Headaches in Eight to Nine-Year-Old Twins

The major objective of the present study was to estimate genetic and environmental influences on recurrent headaches in prepubescent twins. A nationwide cohort of 8 to 9-year-old Swedish twins (n = 1,480) was screened for nonsymptomatic and recurrent headaches through a questionnaire mailed to their parents (75% response frequency). Among positives, 79% of headaches were classified as migraine or tension-type headache in close accordance with the International Headache Society criteria. The prevalences of migraine and nonmigrainous headaches were 2.4% and 11.3%, respectively, and without significant differences between the sexes or zygosity types. Inheritance on liability to recurrent headaches was estimated to 70% (a2 = 0.70, 95% CI = 0.54 − 0.82) for boys and girls but the genetic effect was found to be uncorrelated between the sexes. We conclude that genetic and individual specific effects are important for recurrent headaches of migrainous and nonmigrainous types in prepubescent children, and that different genetic etiologies might exist for boys and girls.
Anal melanoma with satellite implantations on the lower rectum.

Melanoma of the canal anal is a rare malignancy and due to the site of the lesion and the lack of early presenting signs and symptoms, the diagnosis is usually delayed (1,2,3). There is a peak incidence during the seventh decade of life and a marked predominance of female patients, being the hemorrhage, anal pain or anal mass the main complaints. Histologically, it is characterized by a great cellular variability, being able to mimic several other histological types. Thus the immunohistochemical stains, such as S 100 protein and the HMB-45, became a useful instrument in establishing the correct diagnosis. Although it’s a situation that folows with a very low longterm survival, there is no consensus in the best treatment option (3,5,6).
Strategic Knowledge Management, Innovation and Firm Performance: An Empirical Study in Vietnamese Firms

The main purpose of this paper is to test the relationship between strategic knowledge management, innovation and firm performance in the Vietnamese context. Our results show that strategic knowledge management significantly enhances innovation and organizational performance. It is also seen as playing an important mediating role in innovation between strategic knowledge management and firm performance. Although codification and personalization knowledge management strategies both have impact on innovation and performance, personalization knowledge management strategy has the dominant impact.
The impact of exporting on SME capital structure and debt maturity choices

Using a longitudinal dataset comprising of detailed financial and exporting data from Belgian small and medium-sized enterprises (SME) between 1998 and 2013, this article examines the manner in which firms manage to finance their export activities and the resulting impact on corporate capital structure. We find that exporters have to finance relatively more working capital as compared to their non-exporting peers and that they resolve this financing need by carrying more short-term debt. In addition, we evidence that the relationship between pledgeable short-term assets, such as working capital, and short-term debt financing is more pronounced for exporters. In particular, we show that the ties between pledgeable short-term assets and short-term debt financing are stronger for export-intensive firms and firms that serve distant and risky export destinations. Overall, what our empirical findings seem to suggest is that developing tools that facilitate the pledging of assets is likely to boost SME export activities by widening access to bank financing and reducing financial constraints.
Autoproteolysis of herpes simplex virus type 1 protease releases an active catalytic domain found in intermediate capsid particles

The UL26 gene of herpes simplex virus type 1 (HSV-1) encodes a 635-amino-acid protease that cleaves itself and the HSV-1 assembly protein ICP35cd (F. Liu and B. Roizman, J. Virol. 65:5149-5156, 1991). We previously examined the HSV protease by using an Escherichia coli expression system (I. C. Deckman, M. Hagen, and P. J. McCann III, J. Virol. 66:7362-7367, 1992) and identified two autoproteolytic cleavage sites between residues 247 and 248 and residues 610 and 611 of UL26 (C. L. DiIanni, D. A. Drier, I. C. Deckman, P. J. McCann III, F. Liu, B. Roizman, R. J. Colonno, and M. G. Cordingley, J. Biol. Chem. 268:2048-2051, 1993). In this study, a series of C-terminal truncations of the UL26 open reading frame was tested for cleavage activity in E. coli. Our results delimit the catalytic domain of the protease to the N-terminal 247 amino acids of UL26 corresponding to No, the amino-terminal product of protease autoprocessing. Autoprocessing of the full-length protease was found to be unnecessary for catalysis, since elimination of either or both cleavage sites by site-directed mutagenesis fails to prevent cleavage of ICP35cd or an unaltered protease autoprocessing site. Catalytic activity of the 247-amino-acid protease domain was confirmed in vitro by using a glutathione-S-transferase fusion protein. The fusion protease was induced to high levels of expression, affinity purified, and used to cleave purified ICP35cd in vitro, indicating that no other proteins are required. By using a set of domain-specific antisera, all of the HSV-1 protease cleavage products predicted from studies in E. coli were identified in HSV-1-infected cells. At least two protease autoprocessing products, in addition to fully processed ICP35cd (ICP35ef), were associated with intermediate B capsids in the nucleus of infected cells, suggesting a key role for proteolytic maturation of the protease and ICP35cd in HSV-1 capsid assembly.
PHYSICO-CHEMICAL PROPERTIES OF NANO-SIZED HEXAGONAL HYDROXYAPATITE POWDER SYNTHESIZED BY SOL-GEL

order to verify the biocompatibility of HAP powders with hFOB 1.19 osteoblasts cells, an 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test was applied. It was noticed that the ceramics obtained at 1000oC, increased the cell viability with 10%, 40% and 55% after 6, 12 respectively 24 h, whereas that obtained at 600 oC was less effective. Our results proved the high biocompatibility of calcium phosphate ceramic powders obtained by sol-gel and sintered at 1000oC.
Pulmonary lymphangiomyoma, a probable forme frust of tuberous sclerosis. A case report and survey of the literature.

A case of pulmonary lymphangiomyoma in a 40-year-old woman is presented. This rare pulmonary disorder is ostensibly unrelated to tuberous sclerosis, another rare disorder with pulmonary manifestations and with fundamentally identical histologic features. From a review of the world literature, it was concluded that the 2 entities are etiologically related. Evidence for the overlap between the 2 disorders includes relevant genetic studies that explain why a familial history of tuberous sclerosis is not elicitable in patients with pulmonary lymphangiomyoma, the discovery that clinically detectable renal angiomyolipomas represent the most important link in establishing a common etiology, the fact that both occur almost exclusively in females, and identical histologic features.
Is there a relationship between the diameter of the inferior vena cava and hemodynamic parameters in critically ill patients?

INTRODUCTION The early detection of critically ill patients together with the rapid initiation of effective treatment in emergency departments(ED) increase the survival rates. AIM This study investigated whether a correlation exists between haemodynamic parameters of critically ill patients and the diameter of the inferior vena cava (IVC). MATERIALS AND METHODS A cross-sectional study was performed included patients aged ≥18 years with an unstable haemodynamic and/or respiratory status who were referred to the ED for non-traumatic issues. IVC diameters were measured by ultrasound (US) and then central venous pressures (CVP) were measured. Anteroposterior (AP) and mediolateral (ML) diameters of the IVC, both in the inspirium (IAP, IML) and expirium (EAP, EML), were measured by US. RESULTS 102 patients were evaluated with a median age of 59. The relationship between the diameters of IVC and CVP was evaluated and significant correlation was found in IAP, EAP according to CVP values (p<0.001). ROC analyses were performed and significant relationship was found between the EAP diameter with haemoglobin (Hmg), haemotocrit (Hct), and central venous oxygen saturation (ScvO2) and also significant correlation was detected between the IAP diameter and white blood cell (WBC). DISCUSSION We detected significant correlation between the CVP and the IVC diameter in our study compatible with recent studies besides, significant correlation was found between the diameter of the IVC and CVP values as well as between the EAP diameter and Hmg, Hct, ScvO2 levels. CONCLUSION Measurement of IVC diameters, especially EAP may be useful at the monitoring of critically ill patients in ED.
Apoptosis in rabbit haemorrhagic disease.

Rabbit haemorrhagic disease virus (RHDV) causes an acute hepatitis and disseminated intravascular coagulation. Six rabbits were inoculated experimentally with RHDV to investigate any potential relationship between infection and apoptosis in the liver. Two rabbits were killed at 12 h post-inoculation (PI) and two at 24 h PI. The remaining two rabbits died at 30 h and 31 h PI. Immunohistochemical labelling for RHDV antigen-positive cells, TUNEL assay for apoptotic cells, and DNA analysis were performed on samples of liver. The four rabbits that died or were killed 24-31 h PI had acute hepatitis with infiltration of heterophils and necrotic hepatocytes. RHDV antigen-positive cells and apoptotic cells appeared in the centriacinar areas at 12 h PI; subsequently they spread to periacinar areas and increased in number, but the viral antigen-positive cells outnumbered apoptotic cells. At 24-31 h PI, few apoptotic cells were recognized in the areas infiltrated with lymphocytes and heterophils. The results suggested an association between RHDV infection and apoptosis of hepatocytes.
Environmental Factors and Local Government Administration in Nigeria : A Study of Ede North and Ede South Local Government , Osun State , Nigeria ( 1999 - 2014 )

Local governments in Nigeria are not optimally performing as expected partly due to insufficient fund, corruption and lack of autonomy. The focus of this paper is to examine environmental factors affecting the administration of Ede North and Ede South local governments Osun State, Nigeria. The paper was descriptive, combining quantitative and qualitative methods. The two local governments were purposively chosen as no study in that respect had been conducted, while copies of questionnaire were distributed among one hundred respondents selected through random sampling techniques covering officers on GL 07 and above. Six personalities were interviewed including the Timi Agbale of Ede and religious leaders. The data obtained were organized as table with frequency counts while the analysis was descriptive. The paper found the influence of colonialism, Godfatherism, corruption, excessive societal pressure, poor financing and undue interference from state government as major environmental factors while the effect of traditional institution, ethnicity and religion were not pronounced. The paper concluded that the lack of political will by the political class to make Local government work and too much expectations from privileged ones for personal gains could be addresses if Section 8 (6) of 1999 Constitution is amended to minimize state government domineering influence. In addition, political education, inclusive government and the transfer of the functions of State Electoral Commission through constitutional process to Independence National Electoral Commission to guarantee the emergence of enduring democracy at the local level. Kuwait Chapter of Arabian Journal of Business and Management Review Vol. 5, No.7, March 2016
Rarity of Males in Pea Aphids Results in Mutational Decay

When females can reproduce without males, do males become an evolutionarily weaker sex whose genes experience mutational decay? We addressed this hypothesis in aphids, whose reproduction alternates between parthenogenetic and sexual forms: Over the course of a year, there can be 10 to 20 generations of asexual females but only a single, if any, generation with males. We used microarray analyses to identify male-biased, asexual female‐biased, and neutral genes. Interspecific comparisons reveal accelerated evolution of male-biased genes, and intraspecific polymorphisms exhibit a significant excess of nonsynonymous coding variation in male-biased genes. We conclude that the ability of females to reproduce asexually without males reduces selection constraints on male-based genes, resulting in their mutational decay.
Factors Behind Dialysis Patient Satisfaction: Exploring Their Effects on Overall Satisfaction

We would establish a construct of dialysis patients' satisfaction and identify their contribution to overall satisfaction. We also seek to identify present satisfaction levels of Japanese dialysis patients and some important characteristics of their satisfaction/dissatisfaction. A self‐administered questionnaire for measuring dialysis patient satisfaction was developed, which comprised 32 closed‐ended satisfaction question items that were facet‐specific, three items on overall satisfaction, four items on respondent's health status and quality of life as well as demographic information. Reliability and validity of the questionnaire was verified. A questionnaire‐based survey was conducted between July and September 2013. A total of 807 valid responses (63% of response rate) were collected from dialysis patients in 22 facilities located in most regions of Japan. Seven satisfaction factors were derived with 65% of cumulative variance accounted for by applying principal component analysis to responses to facet‐specific satisfaction items. More than 80% of patients expressed positive overall satisfaction and that they wished to continue dialysis therapy in the current facility (they can change dialysis facilities if they wish to). Dialysis patients' overall satisfaction was formulated significantly by five out of seven satisfaction factors by regression analysis. Japanese dialysis patients expressed their high satisfaction with and strong loyalty to the facility where they currently receive dialysis therapy (i.e., patient loyalty). The more satisfied dialysis patients were with the facility, the stronger loyalty they would like to maintain. The overall satisfaction was critically determined by their satisfaction with clinical environment, equipment, treatment and therapy. In addition, patients' quality of life was highly associated with their overall satisfaction.