Miracle-dz/UniFAR-FTUs huggingface dataset:
MTLE: A Multitask Learning Encoder of Visual Feature Representations for Video and Movie Description

Learning visual feature representations for video analysis is a daunting task that requires a large amount of training samples and a proper generalization framework. Many of the current state of the art methods for video captioning and movie description rely on simple encoding mechanisms through recurrent neural networks to encode temporal visual information extracted from video data. In this paper, we introduce a novel multitask encoder-decoder framework for automatic semantic description and captioning of video sequences. In contrast to current approaches, our method relies on distinct decoders that train a visual encoder in a multitask fashion. Our system does not depend solely on multiple labels and allows for a lack of training data working even with datasets where only one single annotation is viable per video. Our method shows improved performance over current state of the art methods in several metrics on multi-caption and single-caption datasets. To the best of our knowledge, our method is the first method to use a multitask approach for encoding video features. Our method demonstrates its robustness on the Large Scale Movie Description Challenge (LSMDC) 2017 where our method won the movie description task and its results were ranked among other competitors as the most helpful for the visually impaired.
Smartphone motor testing to distinguish idiopathic REM sleep behavior disorder, controls, and PD

Objective We sought to identify motor features that would allow the delineation of individuals with sleep study-confirmed idiopathic REM sleep behavior disorder (iRBD) from controls and Parkinson disease (PD) using a customized smartphone application. Methods A total of 334 PD, 104 iRBD, and 84 control participants performed 7 tasks to evaluate voice, balance, gait, finger tapping, reaction time, rest tremor, and postural tremor. Smartphone recordings were collected both in clinic and at home under noncontrolled conditions over several days. All participants underwent detailed parallel in-clinic assessments. Using only the smartphone sensor recordings, we sought to (1) discriminate whether the participant had iRBD or PD and (2) identify which of the above 7 motor tasks were most salient in distinguishing groups. Results Statistically significant differences based on these 7 tasks were observed between the 3 groups. For the 3 pairwise discriminatory comparisons, (1) controls vs iRBD, (2) controls vs PD, and (3) iRBD vs PD, the mean sensitivity and specificity values ranged from 84.6% to 91.9%. Postural tremor, rest tremor, and voice were the most discriminatory tasks overall, whereas the reaction time was least discriminatory. Conclusions Prodromal forms of PD include the sleep disorder iRBD, where subtle motor impairment can be detected using clinician-based rating scales (e.g., Unified Parkinson's Disease Rating Scale), which may lack the sensitivity to detect and track granular change. Consumer grade smartphones can be used to accurately separate not only iRBD from controls but also iRBD from PD participants, providing a growing consensus for the utility of digital biomarkers in early and prodromal PD.
Unfavorable Outcomes Following Surgical Treatment of Hallux Valgus Deformity: A Systematic Literature Review

Background: Surgical correction of deformity plays a central role in the treatment of hallux valgus deformity. However, complications or unintended outcomes are frequently noted in clinical series. There has been no rigorous systematic review of studies reporting outcomes of surgical treatment for hallux valgus deformity, to the best of our knowledge. Methods: We performed a systematic review of studies reporting the outcomes of surgical correction for hallux valgus deformity. Results: A total of 229 studies met the inclusion criteria. The pooled rates of postoperative patient dissatisfaction and postoperative first metatarsophalangeal pain were 10.6% and 1.5%, respectively. The overall rate of recurrent deformity was 4.9%. Conclusions: Hallux valgus surgery has been reported to have fairly consistent results and rates of complications or unfavorable outcomes. Level of Evidence: Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Challenges in Appearance Capture and Predictive Modeling of Textile Materials

The appearance of cloth is the result of complex light interactions within the structures present in textile materials, particularly challenging due to their multi-scale nature. In addition to the inherent complexity of cloth rendering, there is a lack of connection between computer graphics techniques and manufacturing processes followed in industry. We discuss existing techniques and pose questions about which are the right paths to follow for a better synergy between CG and textile research, including (but not restricted to): deﬁning a standard set of properties required to predict the appearance of cloth to be manufactured; developing both acquisition techniques reliable and suitable for industrial processes and other frameworks more focused on inexpensive capturing (e.g. based on single pictures, Pantone labels); ﬁnding material representations that are robust in absence of several low-level parameters; creating a standard for color depth depending on the dye type and dying technique; developing a standard to account for post-process steps (washing, chemical treatments, etc) on the mechanical and optical properties of the textiles. Categories and Subject Descriptors (according to ACM CCS) : I.3. 3 [Computer Graphics]: Picture/Image Generation—Line and curve generation
Radial Pulse Spectrum Analysis as Risk Markers to Improve the Risk Stratification of Silent Myocardial Ischemia in Type 2 Diabetic Patients

Diabetic patients with silent myocardial ischemia (SMI) have elevated rates of morbidity and mortality and need intensive care and monitoring. An early predictor of SMI may lead to early diagnosis and medical treatment to prevent progression and adverse clinical events. Therefore, this paper was aimed to evaluate the radial pulse spectrum as risk markers to improve the risk stratification of SMI in type-2 diabetic patients; 195 diabetic patients at high-risk of SMI were enrolled. All patients underwent myocardial perfusion imaging and radial pressure wave measurement. The spectrum analysis of the radial pressure wave was calculated and transformed into Fourier series coefficients Cns and Pns. The risk of SMI (odds ratio: 4.46, 95%, C.I. 1.61–12.4, <inline-formula> <tex-math notation="LaTeX">$P<0.01$ </tex-math></inline-formula>) was raised in diabetic patients classified high-risk group by C2. Multivariable regression analysis showed that C2 (<inline-formula> <tex-math notation="LaTeX">$P<0.05$ </tex-math></inline-formula>) and ankle–brachial index [(ABI) <inline-formula> <tex-math notation="LaTeX">$P<0.05$ </tex-math></inline-formula>)] were related to SMI (<inline-formula> <tex-math notation="LaTeX">$R=0.46$ </tex-math></inline-formula> and <inline-formula> <tex-math notation="LaTeX">$P<0.05$ </tex-math></inline-formula>). The myocardial ischemic score (MIS), combining C2, C3, and P5, the albumin-to-creatinine ratio (ACR), and ABI, presented an excellent risk stratification performance in enrolled patients (odds ratio: 5.78, 95%, C.I. 2.29–14.6, <inline-formula> <tex-math notation="LaTeX">$P<0.01$ </tex-math></inline-formula>). The area under receiver operating characteristic curves for C2, C3, P5, ABI, ACR, and MIS were 0.66, 0.60, 0.68, 0.51, 0.56, and 0.74, respectively, in identifying SMI. This paper demonstrated that C2 was independently associated with the extent of SMI in multivariable regression analysis. Odds ratio and chi-square tests reflected that C2 could be an important marker for the risk stratification of SMI. Furthermore, MIS, adding radial pulse spectrum analysis to ACR and ABI, could significantly improve the risk stratification of SMI in type-2 diabetic patients compared to any single risk factor.
UBE2G1 governs the destruction of cereblon neomorphic substrates

The immunomodulatory drugs (IMiDs) thalidomide, lenalidomide, and pomalidomide as well as the novel cereblon modulating agents (CMs) including CC-122, CC-220 and cereblon-based proteolysis-targeting chimaeras (PROTACs) repurpose the Cul4-RBX1-DDB1-CRBN (CRL4CRBN) E3 ubiquitin ligase complex to induce the degradation of specific neomorphic substrates via polyubiquitination in conjunction with an E1 ubiquitin-activating enzyme and E2 ubiquitin-conjugating enzymes, which have until now remained elusive. Here we show that the ubiquitin-conjugating enzymes UBE2G1 and UBE2D3 cooperatively promote the polyubiquitination of CRL4CRBN neomorphic substrates in a cereblon- and CM-dependent manner via a sequential ubiquitination mechanism: UBE2D3 transforms the neomorphic substrates into mono-ubiquitinated forms, upon which UBE2G1 catalyzes K48-linked polyubiquitin chain extension. Blockade of UBE2G1 diminishes the ubiquitination and degradation of neomorphic substrates, and consequent antitumor activities elicited by all tested CMs. For example, UBE2G1 inactivation significantly attenuated the degradation of myeloma survival factors IKZF1 and IKZF3 induced by lenalidomide and pomalidomide, hence conferring drug resistance. UBE2G1-deficient myeloma cells, however, remained sensitive to a more potent IKZF1/3 degrader CC-220. Collectively, these findings suggest that loss of UBE2G1 activity might be a resistance mechanism to drugs that hijack the CRL4CRBN to eliminate disease-driving proteins, and that this resistance mechanism can be overcome by next-generation CMs that destroy the same targeted protein more effectively.
Ovarian‐type epithelial tumour of borderline malignancy: a rare testicular tumour in Australia

patients with testicular tumors following orchiopexy, inguinal or scrotal operations. J. Urol. 1973; 110: 223–4. 6. Wheeler JS Jr, Babayan RK, Hong WK, Krane RJ. Inguinal node metastases from testicular tumors in patients with prior orchiopexy. J. Urol. 1983; 129: 1245–7. 7. Boileau MA, Steers WD. Testis tumor: the clinical significance of the tumor-contaminated scrotum. J. Urol. 1984; 132: 51–4. 8. Markland C, Kedia K, Fraley EE. Inadequate orchiectomy in patients with testicular tumors. JAMA 1984; 224: 1025–6. 9. Capelouto CC, Clark PE, Ransil BJ, Loughlin KR. A review of scrotal violation in testicular cancer: is adjuvant local therapy necessary? J. Urol. 1995; 153: 981–5. Mo Li,* MBBS Catrin Stallwood-Hall,* BSc Thomas P. Cundy,*† MBBS, PhD Alexander Jay,*‡ FRACS *Department of Urology, Flinders Medical Centre, Adelaide, South Australia, Australia, †Discipline of Surgery, The University of Adelaide, Adelaide, South Australia, Australia and ‡Discipline of Surgery, Flinders University, Adelaide, South Australia, Australia
More important and surprising actions of a moral exemplar trigger stronger admiration and inspiration

ABSTRACT Admiring a moral role model has been found to inspire people to become better persons themselves. But what are the antecedents that trigger admiration and thus make inspiration more likely? In three studies, we tested the effect of perceived importance and perceived surprisingness of the moral action on resulting admiration and inspiration. Study 1 finds that perceived importance, and to a lesser extent, the perceived surprisingness of a moral action, are related to stronger admiration. Manipulating the perceived importance of the same moral action by only providing a little more detail about the moral action, could increase the admiration and inspiration the role models elicit (Studies 2 and 3). Our findings help the understanding of how moral exemplars trigger inspiration and provide valuable insights into further investigation toward the causes of admiration.
Adherence to the Healthy Nordic Food Index in the Norwegian Women and Cancer (NOWAC) cohort

Background High adherence to the Healthy Nordic Food Index has been associated with better health outcomes, but the results have not been consistent. The association between high adherence and higher intake of energy and healthy and less healthy foods has been persistent across countries, highlighting the need to examine potential confounding by energy intake. Objective This study aimed to examine energy-adjusted dietary factors and lifestyle factors related to the index in a Norwegian context. Design The study was cross-sectional within the Norwegian Women and Cancer cohort and included 81,516 women aged 41–76. Information about habitual food intake was based on a food frequency questionnaire (FFQ). The index incorporated six food groups (fish, root vegetables, cabbages, apples/pears, whole grain bread, and breakfast cereals). Ordered trend and regression analyses were performed to assess the association between the index and lifestyle and dietary factors with energy-adjusted models. Results Nearly one out of four women (22.8%) had low adherence, 49.0% had medium adherence, and 28.2% had high adherence to the index. Intake of energy and of both healthy and less healthy foods increased with increased adherence. Energy adjustment removed the associations between less healthy foods and high adherence and demonstrated a better dietary composition in high adherers. The healthy Nordic foods contributed more to the total food intake in high versus low adherers, and high adherence was associated with a healthier lifestyle. Conclusion High adherence was associated with a healthier lifestyle, both concerning diet and other factors. Energy adjustment of potential confounding foods removed associations between high adherence and less healthy foods. The Nordic foods accounted for a larger fraction of the diet among high adherers, at the expense of other healthy foods. Careful adjustment for confounders is warranted when assessing associations between the index and health outcomes.
Glucocorticoids reduce chemotherapeutic effectiveness on OSCC cells via glucose‐dependent mechanisms

Synthetic corticosteroids are routinely administered during the treatment of several diseases, including malignancies. However, recent evidence suggests that corticosteroids may have tumor‐promoting effects, particularly in epithelial neoplasms. Our aim was to assess the role of the recently characterized cancer‐associated glucocorticoid (GC) system in the resistance to chemotherapy of oral malignant keratinocytes. Human malignant oral keratinocyte cell lines H314/H357/H400/BICR16/BICR56 were tested with: two chemotherapeutic agents, doxorubicin (DOXO) and 5‐fluorouracil (5‐FU), as well as hydrocortisone (HC), adrenocorticotropic hormone (ACTH), 5‐pregnen‐3‐beta‐ol‐20‐one‐16‐alfa‐carbonitrile (PCN), and two glucose uptake inhibitors, Fasentin and WZB. Both DOXO and 5‐FU induced apoptosis in a dose‐dependent and time‐dependent manner. HC administration (100 nM) reduced the effectiveness of both chemotherapeutic agents to a variable extent in all 5 oral squamous cell carcinoma cell lines. ACTH also reduced the effectiveness of DOXO on 2 cell lines tested (H357 and BICR56). The glucose uptake inhibitors Fasentin and WZB were able to partially block the increased resistance to the cytotoxic drugs induced by HC. In summary, we have demonstrated, for the first time, the importance of cortisol on oral cancer cells ability to proliferate and combat the effectiveness of chemotherapeutic agents. This effect appears to be glucose dependent.
Theta Activity in the Left Dorsal Premotor Cortex During Action Re-Evaluation and Motor Reprogramming

The ability to rapidly adjust our actions to changes in the environment is a key function of human motor control. Previous work implicated the dorsal premotor cortex (dPMC) in the up-dating of action plans based on environmental cues. Here we used electroencephalography (EEG) to identify neural signatures of up-dating cue-action relationships in the dPMC and connected frontoparietal areas. Ten healthy subjects performed a pre-cued alternate choice task. Simple geometric shapes cued button presses with the right or left index finger. The shapes of the pre-cue and go-cue differed in two third of trials. In these incongruent trials, the go-cue prompted a re-evaluation of the pre-cued action plan, slowing response time relative to trials with identical cues. This re-evaluation selectively increased theta band activity without modifying activity in alpha and beta band. Source-based analysis revealed a widespread theta increase in dorsal and mesial frontoparietal areas, including dPMC, supplementary motor area (SMA), primary motor and posterior parietal cortices (PPC). Theta activity scaled positively with response slowing and increased more strongly when the pre-cue was invalid and required subjects to select the alternate response. Together, the results indicate that theta activity in dPMC and connected frontoparietal areas is involved in the re-adjustment of cue-induced action tendencies.
Immune Thrombocytopenia - Current Diagnostics and Therapy: Recommendations of a Joint Working Group of DGHO, ÖGHO, SGH, GPOH, and DGTI

a Department of Internal Medicine II, Asklepios Clinic Uckermark, Schwedt, Germany; b Institute for Transfusion Medicine, Charité – Medical University Berlin, Berlin, Germany; c Department of Medicine III, University Hospital, Ludwig Maximilian University, Munich, Germany; d Institute for Transfusion Medicine, Medical University Rostock, Rostock, Germany; e Hospital for Children’s and Youth Medicine, Braunschweig Municipal Hospital, Braunschweig, Germany; f Division of Oncology/Hematology, University Children’s Hospital, Basel, Switzerland; g Clinical Division of Hematology and Hemostaseology, Department of Medicine I, Medical University of Vienna, Vienna, Austria; h Department of Hematology & Oncology, University Hospital Gießen, Gießen, Germany
A feedback loop between dipeptide-repeat protein, TDP-43 and karyopherin-α mediates C9orf72-related neurodegeneration

TDP-43 accumulation is a major pathological hallmark of amyotrophic lateral sclerosis and frontotemporal dementia, including the most common genetic cause, G4C2 hexanucleotide repeat expansion in C9ORF72 (C9ALS/FTD). Solomon et al. report that G4C2-derived dipeptide repeat protein but not G4C2-RNA accumulation causes TDP-43 proteinopathy that triggers onset and progression of disease.
Effect of specially designed oral health preventive programme on oral health of visually impaired children: use of audio and tactile aids.

INTRODUCTION Contemporary methods of teaching oral hygiene for the removal of dental plaque are not beneficial for visually impaired children, who depend on tactile sensations and hearing for learning. The present study was conducted to educate and motivate visually impaired children to maintain their oral health using specially designed methods that are easy for these children to understand. Additionally, the study evaluated the effectiveness of these methods over a 6-month period. METHODOLOGY The investigation was done on 148 visually impaired children who were residents of two institutes for the visually impaired. The efficacy of a specially designed oral health education programme and two different motivational techniques utilising tactile (Group I: braille + plastic models) or auditory sensations (Group II: audio story + JAWS® , i.e. Job Access With Speech) was evaluated over 6 months based on the children's plaque and gingival scores. RESULTS Significant improvement in mean plaque and gingival scores was evident in both the groups at the 6-month evaluation, validating the effectiveness of both the programmes. In Group I, the mean plaque score decreased from 1.34 ± 0.29 at baseline to 1.09 ± 0.26 at 3 months, with a further decrease to 1.04 ± 0.31 at 6 months post-implementation (P < 0.01). The mean plaque score in Group II decreased from 1.24 ± 0.47 at baseline to 1.15 ± 0.15 at 3 months (P = 0.12), and further to 1.10 ± 0.17 at 6 months (P < 0.01) post-implementation of the educational programme. At baseline, 87.8% of the children in Group I had moderate gingivitis, whereas 52.7% of the children in Group II belonged to the mild category. At the end of 6 months, 52.7% of the children in Group I were in the mild category, and 62.2% children in Group II were in the moderate category. CONCLUSION Tactile and auditory measures were found to be effective in educating and motivating visually impaired children regarding maintenance of oral hygiene.
Aloe Genus Plants: From Farm to Food Applications and Phytopharmacotherapy

Aloe genus plants, distributed in Old World, are widely known and have been used for centuries as topical and oral therapeutic agents due to their health, beauty, medicinal, and skin care properties. Among the well-investigated Aloe species are A. arborescens, A. barbadensis, A. ferox, and A. vera. Today, they account among the most economically important medicinal plants and are commonly used in primary health treatment, where they play a pivotal role in the treatment of various types of diseases via the modulation of biochemical and molecular pathways, besides being a rich source of valuable phytochemicals. In the present review, we summarized the recent advances in botany, phytochemical composition, ethnobotanical uses, food preservation, and the preclinical and clinical efficacy of Aloe plants. These data will be helpful to provide future directions for the industrial and medicinal use of Aloe plants.
Undergraduate students survey their peers on mental health: Perspectives and strategies for improving college counseling center outreach

Abstract Objective: The purpose of the study was to examine student perspectives about college mental health including the primary mental health issues affecting students, common college student stressors, student awareness of campus mental health resources, and mental health topics students want more information about. Participants: Participants were 822 undergraduate and graduate students enrolled in a private university. The study was conducted during September 2016. Methods: As part of a public health course in program planning, undergraduate students surveyed their peers about their experience with mental health and mental health resources. Results: Stress was perceived as the largest mental health issue. Students most wanted more information about school/work/life balance followed by stress management. Electronic newsletters, social media, and on-campus seminars were the top strategies that students suggested as ways to reach them. Conclusions: The results provide student perspectives on mental health that may be useful in developing effective outreach efforts.
The effects of asymmetric volume conductor modeling on non-invasive fetal ECG extraction

Objective: Non-invasive fetal electrocardiography (NI-FECG) shows promise for capturing novel physiological information that may indicate signs of fetal distress. However, significant deterioration in NI-FECG signal quality occurs during the presence of a highly non-conductive layer known as vernix caseosa which forms on the fetal body surface beginning in approximately the 28th week of gestation. This work investigates asymmetric modeling of vernix caseosa and other maternal–fetal tissues in accordance with clinical observations and assesses their impacts for NI-FECG signal processing. Approach: We develop a process for simulating dynamic maternal–fetal abdominal ECG mixtures using a synthetic cardiac source model embedded in a finite element volume conductor. Using this process, changes in NI-FECG signal morphology are assessed in an extensive set of finite element models including spatially variable distributions of vernix caseosa. Main results: Our simulations show that volume conductor asymmetry can result in over 70% error in the observed T/QRS ratio and significant changes to signal morphology compared to a homogeneous volume conductor model. Volume conductor effects must be considered when analyzing T/QRS ratios obtained via NI-FECG and should be considered in future algorithm benchmarks using simulated data. Significance: This work shows that without knowledge of the influence of volume conductor effects, clinical evaluation of the T/QRS ratio derived via NI-FECG should be avoided.