Miracle-dz/UniFAR-FTUs huggingface dataset:
Constructivist Blended Learning Approach: to Teaching English for Specific Purposes

The principles in questions are required for setting clear and accurate reference points that are needed for practical implementation of the constructivist blended learning approach. They are kinds of teaching practice-oriented guidelines as to what and how should be done in the practical process of teaching and learning to provide for the successful learning outcomes of that entire process. The principles: 1) practically regulate teaching/learning content selection in order to make the instruction genuinely professional content based (theme-based); 2) practically regulate the use of experiential interactive learning activities in the ESP course; 3) practically prepare students for working on the Internet, and 4) therefore, form a firm foundation for developing the organizational model of every particular ESP course which finalizes the practical development of such a course as a whole. It has already been said in the Introduction that five of such practical principles have been postulated by us. They include: 1. the principle of systematizing professional information in the coursebook and course of English for Specific Purposes; 2. the principle of authenticity of students' learning activities and learning communication; 3. the principle of authenticity of learning materials; k. the principle of integrating English speaking, listening, reading, and writing in the learning process; 5. the principle of developing students' informative competence in English.
The impact of the anesthetic conserving device on occupational exposure to isoflurane among intensive care healthcare professionals.

BACKGROUND Use of anesthetic conserving devices (ACD) for inhalational isoflurane sedation in Intensive Care Units (ICU) has grown in recent years, and healthcare professionals are concerned about isoflurane pollution and exposure-related health risks. Real-time measurements to determine isoflurane exposure in ICU personnel during short-term patient care procedures and ACD handling have not yet been performed. METHODS Isoflurane concentrations in the breathing zones of ICU staff (25 cm around the nose and mouth) were measured, by photoacoustic gas monitoring, during daily practice including tracheal suctioning, oral hygiene, body care, and patient positioning. Isoflurane pollution was further determined during ACD replacement, syringe filling, and after isoflurane spillages. RESULTS The average mean isoflurane concentration 25 cm above patients' tracheostoma was 0.3 ppm. Mean (cmean) and maximum (cmax) isoflurane exposure in personnel's breathing zones during patient care ranged from 0.4 to 1.9 ppm and 0.7 to 6.6 ppm, respectively. Isoflurane exposure during ACD replacement was cmean 0.5 to 17.4 ppm and cmax 0.8 to 114.3 ppm. Isoflurane concentrations during ACD syringe filling ranged from 2.4 to 9.1 ppm. The maximum isoflurane concentrations after spillage were dose-dependent. CONCLUSIONS Use of ACDs and patient physical manipulation are accompanied by isoflurane pollution. Baseline concentrations did not exceed long-term exposure limits, but short-term limits were occasionally exceeded during patient care procedures and ACD handling. Spillages should be avoided, especially when air-conditioning and scavenging systems are unavailable.
The hepatitis C virus nonstructural protein 3 Q80K polymorphism is frequently detected and transmitted among HIV-infected MSM in the Netherlands

Objectives: The Q80K polymorphism is a naturally occurring resistance-associated variant in the hepatitis C virus (HCV) nonstructural protein 3 (NS3) region and is likely transmissible between hosts. This study describes the Q80K origin and prevalence among HCV risk groups in the Netherlands and examines whether Q80K is linked to specific transmission networks. Design and methods: Stored blood samples from HCV genotype 1a-infected patients were used for PCR and sequencing to reconstruct the NS3 maximum likelihood phylogeny. The most recent common ancestor was estimated with a coalescent-based model within a Bayesian statistical framework. Results: Study participants (n = 150) were either MSM (39%), people who inject drugs (17%), or patients with other (15%) or unknown/unreported (29%) risk behavior. Overall 45% was coinfected with HIV. Q80K was present in 36% (95% confidence interval 28–44%) of patients throughout the sample collection period (2000–2015) and was most prevalent in MSM (52%, 95% confidence interval 38–65%). Five MSM-specific transmission clusters were identified, of which three exclusively contained sequences with Q80K. The HCV-1a most recent common ancestor in the Netherlands was estimated in 1914 (95% higher posterior density 1879–1944) and Q80K originated in 1957 (95% higher posterior density 1942–1970) within HCV-1a clade I. All Q80K lineages could be traced back to this single origin. Conclusion: Q80K is a highly stable and transmissible resistance-associated variant and was present in a large part of Dutch HIV-coinfected MSM. The introduction and expansion of Q80K variants in this key population suggest a founder effect, potentially jeopardizing future treatment with simeprevir.
Tail risk in emerging markets of Southeastern Europe

ABSTRACT This article examines the left-tail behaviour of returns on stocks in Southeastern Europe (SEE). We apply conditional extreme value theory (EVT) approach on daily returns of six stock market indices from SEE between 2004 and 2013. Predictive performance of value-at-risk (VaR) and expected shortfall (ES) based on EVT is compared against several alternatives, such as historical simulation and analytical approach based on GARCH with a single conditional distribution. Model backtesting with daily returns shows that EVT-based models provide more reliable VaR and ES forecasts than the alternative models in all six markets. Unlike the alternatives, the EVT-based models cannot be rejected as VaR confidence level is increased. This emphasizes the importance of extreme events in SEE markets and indicates that the ability of a model to capture volatility clustering accurately is not sufficient for a correct assessment of risk in these markets.
INFLUENCES OF PARAMETER UNCERTAINTIES WITHIN THE ICRP-66 RESPIRATORY TRACT MODEL: REGIONAL TISSUE DOSES FOR 239PuO2 AND 238UO2/238U3O8

Abstract— This paper extends an examination of the influence of parameter uncertainties on regional doses to respiratory tract tissues for short-ranged alpha particles using the ICRP-66 respiratory tract model. Previous papers examined uncertainties in the deposition and clearance aspects of the model. The critical parameters examined in this study included target tissue depths, thicknesses, and masses, particularly within the thoracic or lung regions of the respiratory tract. Probability density functions were assigned for the parameters based on published data. The probabilistic computer code LUDUC (Lung Dose Uncertainty Code) was used to assess regional and total lung doses from inhaled aerosols of 239PuO2 and 238UO2/238U3O8. Dose uncertainty was noted to depend on the particle aerodynamic diameter. Additionally, dose distributions were found to follow a lognormal distribution pattern. For 239PuO2 and 238UO2/238U3O8, this study showed that the uncertainty in lung dose increases by factors of ∼50 and ∼70 for plutonium and uranium oxides, respectively, over the particle size range from 0.1 to 20 &mgr;m. For typical exposure scenarios involving both radionuclides, the ratio of the 95% dose fractile to the 5% dose fractile ranged from ∼8–10 (corresponding to a geometric standard deviation, or GSD, of about 1.7–2) for particle diameters of 0.1 to 1 &mgr;m. This ratio increased to about 370 for plutonium oxide (GSD ∼4.5) and to about 600 for uranium oxide (GSD ∼5) as the particle diameter approached 20 &mgr;m. However, thoracic tissue doses were quite low at larger particle sizes because most of the deposition occurred in the extrathoracic airways. For 239PuO2, median doses from LUDUC were found be in general agreement with those for Reference Man (via deterministic LUDEP 2.0 calculations) in the particle range of 0.1 to 5 &mgr;m. However, median doses to the basal cell nuclei of the bronchial airways (BBbas) calculated by LUDUC were found to be approximately 6 times higher than LUDEP reference doses. The higher BBbas doses were directly attributed to discrepancies between the ICRP default thickness for the bronchial epithelium (55 &mgr;m) and the probability density function assumed within LUDUC (uniform distribution from 20 to 60 &mgr;m based upon detailed literature reviews).
Stability of morphotropic <110> oriented 0.65PMN-0.35PT single crystals

Electromechanical properties of (1-x)Pb (Mg/sub 1/3/Nb/sub 2/3/)O/sub 3-x/PbTiO/sub 3/ (PMN-PT) single crystals with x=0.35 were investigated as a function of different external disturbances. The polarization dependence on the electromechanical properties was first studied in order to determine the best polarization path. The correlation with X-ray measured phase ratio is presented and shows that the maximum of electromechanical properties may be correlated with a minimum rhombohedral/tetragonal phase ratio. Temperature, stress, electric field, and time (aging) stability was studied in order to determine performance-limiting factors of these materials. The rhombohedral/tetragonal phase transition is observed on temperature (80/spl deg/C), inducing a decrease of the electromechanical coupling factor (from 85% to 50%); but the whole properties are recovered while returning to room temperature. Stress measurement shows a large depoling of sample for stresses above 30 MPa. The PMN-PT single crystals were found to be surprisingly stable during aging, except for mechanical and dielectric losses. The same tendency was found on alternating current (AC) electric field dependence.
First myocardial infarction in a Dutch general practice population: trends in incidence from 1975-2003.

BACKGROUND As morbidity registrations generally do not make distinct first and following myocardial infarctions, it is still unclear as to what extent the falling rates of myocardial infarctions are caused by lower incidences of first myocardial infarctions. AIM To investigate the incidence of first myocardial infarctions in a general practice population. METHOD Data were taken from the Continuous Morbidity Registration (CMR) Nijmegen, which has been collecting data from four general practices since 1971. For the 1975-2003 period, sex-specific and age-specific yearly incidence rates were obtained from the registration data of the CMR. Trends were studied with Poisson regression. RESULTS During the study period, 827 patients with a first myocardial infarction were identified. The incidence of first myocardial infarctions has declined since 1986 to 2.1 per 1000 for men and to 1.5 per 1000 for women. The average age of getting a first myocardial infarction increased with 3 years for men and slightly decreased for women. Since 1986, the incidence of sudden cardiac death from a first myocardial infarction has considerably declined for men and women to 0.9 and 0.7 per 1000 respectively. CONCLUSION A slight, significant, decline in incidence of first myocardial infarctions was found. From the mid eighties a mean annual decline of 3.5% in death from first myocardial infarction was observed. Though the variance in rates of coronary heart diseases is not unambiguous, this may indicate an effect of primary prevention. The decline was more pronounced in men, with an increasing age of getting a first myocardial infarction.
Working through Mass Incarceration: Gender and the Politics of Prison Labor from East to West

This article explores the politics and practices of labor in two penal institutions for women: a maximum security facility for women in Hungary and a community‐based facility for women in California. Diverging from other accounts of imprisonment that tend to operate at either the individual or macroeconomic level, this article analyzes the concrete institutional relations of prison and complicates the assumption that they simply reflect the logic of the prison‐industrial complex. Based on years of ethnographic work in two very different penal systems, I describe variation in how prisons institute labor within and across institutions and cultures: the Hungarian facility positioned wage labor as a right and an obligation that formed the basis of women’s social relationships and ties to others, while the U.S. prison excluded wage labor from women’s lives so they could get on with the work of self‐improvement and personal healing. From the comparison, I reveal how prisons can both draw on and subvert broader social meanings assigned to women’s work, making it difficult to view prison labor as wholly exploitative or abusive. I also argue that refusing to allow female inmates to engage in wage labor can be a more profound form of punishment than requiring it of them. By juxtaposing the discourses and practices of work in two very different penal contexts, this article offers a critical reflection on the political economy of prison labor from the ground up.
Classification of Arabic Twitter Users: A Study Based on User Behaviour and Interests

Social networks are among the most popular interactive media today due to their simplicity and their ability to break down the barriers of community rules and their speed and because of the increasing pressures of work environments that make it more difficult for people to visit or call friends. There are many social networking products available and they are widely used for social interaction. As the amount of threading data is growing, producing analysis from this large volume of communications is becoming increasingly difficult for public and private organisations. One of the important applications of this work is to determine the trends in social networks that depend on identifying relationships between members of a community. This is not a trivial task as it has numerous challenges. Information shared between social members does not have a formal data structure but is transmitted in the form of texts, emoticons, and multimedia. The inspiration for addressing this area is that if a company is advertising a sports product, for example, it has a difficulty in identifying targeted samples of Arab people on social networks who are interested in sports. In order to accomplish this, an experiment oriented approach is adopted in this study. A goal for this company is to discover users who have been interacting with other users who have the same interests, so they can receive the same type of message or advertisement. This information will help a company to determine how to develop advertisements based on Arab people’s interests. Examples of such work include the timely advertisement of the utilities that can be effectively marketed to increase the audience; for example, on the weekend days, the effective market approaches can yield considerable results in terms of increasing the sales and profits. In addition, finding an efficient way to recommend friends to a user based on interest similarity, celebrity degree, and online behaviour is of interest to social networks themselves. This problem is explored to establish and apply an efficient and easy way to classify a social network of Arab users based on their interests using available types of information, whether textual or nontextual, and to try to increase the accuracy of interest classification. Since most of the social networking is done from the mobiles nowadays, the efficient and reliable algorithm can help in developing a robust app that can perform the tweet classification on mobile phones.
Dominance and Sexual Dimorphism Pervade the Salix purpurea L. Transcriptome

Abstract The heritability of gene expression is critical in understanding heterosis and is dependent on allele-specific regulation by local and remote factors in the genome. We used RNA-Seq to test whether variation in gene expression among F1 and F2 intraspecific Salix purpurea progeny is attributable to cis- and trans-regulatory divergence. We assessed the mode of inheritance based on gene expression levels and allele-specific expression for F1 and F2 intraspecific progeny in two distinct tissue types: shoot tip and stem internode. In addition, we explored sexually dimorphic patterns of inheritance and regulatory divergence among F1 progeny individuals. We show that in S. purpurea intraspecific crosses, gene expression inheritance largely exhibits a maternal dominant pattern, regardless of tissue type or pedigree. A significantly greater number of cis- and trans-regulated genes coincided with upregulation of the maternal parent allele in the progeny, irrespective of the magnitude, whereas the paternal allele was higher expressed for genes showing cis × trans or compensatory regulation. Importantly, consistent with previous genetic mapping results for sex in shrub willow, we have delimited sex-biased gene expression to a 2 Mb pericentromeric region on S. purpurea chr15 and further refined the sex determination region. Altogether, our results offer insight into the inheritance of gene expression in S. purpurea as well as evidence of sexually dimorphic expression which may have contributed to the evolution of dioecy in Salix.
Keloidal atypical fibroxanthoma: a case series

Background: Keloidal atypical fibroxanthoma (AFX) is a rare variant of AFX with thick bands of hyalinized collagen. The identification of keloidal collagen associated with fibrohistiocytic cells may erroneously lead to the diagnosis of keloidal dermatofibroma. Although AFX is a pleomorphic cutaneous tumor typically associated with a good prognosis, occasional reports of metastatic AFX highlight the importance of accurate identification.
CADASIL: Extended polymorphisms and mutational analysis of the NOTCH3 gene

CADASIL is a cerebrovascular disease caused by mutations in the NOTCH3 gene. Most mutations result in a gain or loss of cysteine residue in one of the 34 epidermal growth factor‐like repeats in the extracellular domain of the Notch3 protein, thus sparing the number of cysteine residues. To date, more than 130 different mutations in the NOTCH3 gene have been reported in CADASIL patients, of which 95% are missense point mutations. Many polymorphisms have also been identified in the NOTCH3 coding sequence, some of them leading to amino acid substitutions. The aim of the present study was to analyze the NOTCH3 gene in a large group of patients affected by leukoencephalopathy and to investigate the presence of genetic variants. The molecular analysis revealed several nucleotide alterations. In particular, we identified 20 different mutations, 22 polymorphisms, and 8 genetic variants of unknown pathological significance never reported previously. We hope that this NOTCH3 gene mutational analysis, performed in such a significant number of unrelated and related patients affected by leukoencephalopathy, will help in molecular screening for the NOTCH3 gene, thus contributing to enlargement of the NOTCH3 gene variation database. © 2008 Wiley‐Liss, Inc.
Changes in Body Image Experienced by Adolescents With Cancer

Cancer and its treatments affect adolescents’ body image. However, it is not known what factors impinge on adolescents’ perception of their body image. This multiple case study explored how 5 adolescents with cancer perceived their body image and the impact of this perception on their daily life. Adolescents described their body image as “I don’t look normal,” a theme that comprised 2 dimensions: “I look ugly” and “I look sick. ” For the adolescent with cancer, these 2 dimensions evoked feelings of being vulnerably exposed: “People look at me. ” Consequently, adolescents adopted a new set of coping strategies to help them manage their physical appearance and social interactions: “avoiding,” “maintaining normality,” “testing the waters,” and “peer-shield” themes. Although the adolescents perceived their body image as altered, coping mechanisms enabled adolescents to think of themselves as normal and re-establish their social lives. The results of this small study suggest 2 potential nursing approaches to facilitate adolescents’ adaptation to their new body image.
Fine‐needle aspiration in myxofibrosarcoma: Experience of Institut Curie

Myxofibrosarcoma (MFS) is a well‐established nosologic entity different from the myxoid variant of malignant fibrous histiocytoma. In an attempt to better define the representative cytologic criteria of MFS, we undertook a review and a reanalysis of a series of 14 cytology samples in 12 patients whose tumors were diagnosed as MFS.
Very-low-birthweight infants and income incongruity among African American and white parents in Chicago.

OBJECTIVES Illinois vital records for 1982/1983 and US census income data for 1980 were analyzed to ascertain the relationship of income incongruity, race, and very low birthweight. METHODS Positive income incongruity was considered present when study infants resided in wealthier neighborhoods than non-Latino Whites at the same level of parental education attainment and marital status. RESULTS The odds ratios of very low birthweight for African Americans (n = 44,266) and Whites (n = 27,139) who experienced positive income incongruity were 0.7 (95% confidence interval [CI] = 0.5, 0.9) and 0.6 (95% CI = 0.5, 0.9), respectively. CONCLUSIONS Positive income incongruity is associated with lower race-specific rates of very low birthweight.
Lysosomal pH Plays a Key Role in Regulation of mTOR Activity in Osteoclasts

Mammalian target of rapamycin (mTOR) is a serine/threonine kinase involved in the regulation of cell growth. It has been shown to play an important role in osteoclast differentiation, particularly at the earlier stages of osteoclastogenesis. mTOR activation and function, as part of mTORC1 complex, is dependent on lysosomal localization and the vacuolar H+‐ATPase (V‐ATPase) activity; however, the precise mechanism is still not well understood. Using primary mouse osteoclasts that are known to have higher lysosomal pH due to R740S mutation in the V‐ATPase a3 subunit, we investigated the role of lysosomal pH in mTORC1 signaling. Our results demonstrated that +/R740S cells had increased basal mTOR protein levels and mTORC1 activity compared to +/+ osteoclasts, while mTOR gene expression was decreased. Treatment with lysosomal inhibitors chloroquine and ammonium chloride, compounds known to raise lysosomal pH, significantly increased mTOR protein levels in +/+ cells, confirming the importance of lysosomal pH in mTOR signaling. These results also suggested that mTOR could be degraded in the lysosome. To test this hypothesis, we cultured osteoclasts with chloroquine or proteasomal inhibitor MG132. Both chloroquine and MG132 increased mTOR and p‐mTOR protein levels in +/+ osteoclasts, suggesting that mTOR undergoes both lysosomal and proteasomal degradation. Treatment with cycloheximide, an inhibitor of new protein synthesis, confirmed that mTOR is constitutively expressed and degraded. These results show that, in osteoclasts, the lysosome plays a key role not only in mTOR activation but also in its deactivation through protein degradation, representing a novel molecular mechanism of mTOR regulation. J. Cell. Biochem. 117: 413–425, 2016. © 2015 Wiley Periodicals, Inc.