Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinically Relevant Patch Test Results in Patients With Burning Mouth Syndrome

BackgroundPatients with a sore or burning mouth associated with clinically normal oral mucosa present a difficult diagnostic challenge. ObjectiveThe objective of this study was to assess the value of patch testing in patients with burning mouth syndrome. MethodsWe retrospectively reviewed the results of patch testing to an oral series in patients with burning mouth syndrome seen at Mayo Clinic, Rochester, Minnesota, between January 2000 and April 2006. ResultsOf 195 consecutive patients with a burning or sore mouth, 75 had patch testing to an oral series, and 28 of these patients (37.3%) had allergic patch test reactions. The most common allergens were nickel sulfate hexahydrate 2.5%, balsam of Peru, and gold sodium thiosulfate 0.5%. On follow-up, 15 patients reported improvement, 4 removed or avoided the offending dental metal, and 6 avoided the dietary allergen. Thirteen patients did not improve; 6 avoided identified allergens, but without improvement; 1 removed dental metals without symptom change; and 5 avoided test-positive dietary allergens but without improvement. The remaining 7 nonresponders had nonrelevant patch test results or did not avoid allergens. ConclusionsPatch testing can identify patients who may be allergic to dental metals or dietary additives and who may benefit from removal or avoidance of these.
Differential mycobacterial 65-kDa heat shock protein T cell epitope recognition after adjuvant arthritis-inducing or protective immunization protocols.

Immunization of Lewis rats with heat-killed Mycobacterium tuberculosis (Mt) in mineral oil induces adjuvant arthritis (AA), associated with T cell responses to residues 180-188 of the mycobacterial 65-kDa heat shock protein (hsp65). Preimmunization with hsp65 protects rats against AA and other forms of arthritis. Several explanations for these protective effects have been proposed, including enhanced responsiveness to protective epitopes in hsp65, down-regulation of T cell responses to the 180-188 epitope, and activation of self-hsp60-reactive T cells. To assess the potential of these hypotheses, we analyzed hsp65 T cell epitopes recognized after immunization of Lewis rats with Mt or hsp65. Here we identify nine RT1.B1-restricted T cell epitopes in hsp65. Mt immunization induced T cell responses in which the 180-188 epitope was dominant, whereas hsp65 immunization resulted in a co-dominance of this and two further epitopes, 216-225 and 226-235. Two minor epitopes were recognized after hsp65 but not Mt immunization. These results indicate that hsp65 preimmunization does not down-regulate responses to the AA-associated epitope, but does enhance responses to several hsp65 epitopes that are minor or absent after the AA-inducing immunization protocol. Cross-reactive T cell recognition of hsp65 and rat hsp60 was limited to a single epitope (256-265), recognized after hsp65 immunization, but poorly recognized after Mt immunization. This study provides the necessary basis for elucidating the T cell events involved in the protective effects of hsp65 preimmunization.
Memo No . 70 October 31 , 2017 Object-Oriented Deep Learning by

We investigate an unconventional direction of research that aims at converting neural networks, a class of distributed, connectionist, sub-symbolic models into a symbolic level with the ultimate goal of achieving AI interpretability and safety. To that end, we propose Object-Oriented Deep Learning, a novel computational paradigm of deep learning that adopts interpretable “objects/symbols” as a basic representational atom instead of N-dimensional tensors (as in traditional “feature-oriented” deep learning). For visual processing, each “object/symbol” can explicitly package common properties of visual objects like its position, pose, scale, probability of being an object, pointers to parts, etc., providing a full spectrum of interpretable visual knowledge throughout all layers. It achieves a form of “symbolic disentanglement”, offering one solution to the important problem of disentangled representations and invariance. Basic computations of the network include predicting high-level objects and their properties from low-level objects and binding/aggregating relevant objects together. These computations operate at a more fundamental level than convolutions, capturing convolution as a special case while being significantly more general than it. All operations are executed in an input-driven fashion, thus sparsity and dynamic computation per sample are naturally supported, complementing recent popular ideas of dynamic networks and may enable new types of hardware accelerations. We experimentally show on CIFAR-10 that it can perform flexible visual processing, rivaling the performance of ConvNet, but without using any convolution. Furthermore, it can generalize to novel rotations of images that it was not trained for. This work was supported by the Center for Brains, Minds and Machines (CBMM), funded by NSF STC award CCF 1231216.
Platelet Interactions with Dacron Vascular Grafts: A Model of Acute Thrombosis in Baboons

We have developed a model of acute Dacron graft thrombosis in baboons in order to assess platelet alterations secondary to arterial thrombus formation. In this model, thrombus formation was initiated by Dacron vascular grafts inserted as extension segments into chronic arteriovenous Silastic shunts. Following platelet labeling with 111ln-oxine, platelet deposition was measured for 1 hour following blood contact under arterial flow conditions using a scintillation camera. Graft platelet activity rapidly increased 40- to 50-fold, plateauing by 1 hour. All grafts produced equivalent reductions in circulating platelet count and blood 111ln-platelet radioactivity, demonstrating that the labeled cells were functionally equivalent to the total platelet population. After graft placement, the remaining platelets survived normally. Acute platelet deposition was equivalent on grafts placed 1, 24, 48, and 72 hours following injection of the labeled cells, indicating that a variable delay between platelet labeling and graft imaging was without detectable consequence. Platelet destruction by the graft produced a tenfold increase in plasma levels of platelet factor 4 (PF4) and B-thromboglobulin (BTG) but did not modify either the α-granule (PF4,13TG) or dense granule (ADP, ATP) contents of circulating platelets.
Spinal anesthesia versus general anesthesia in laparoscopic cholecystectomy : a comparative study

Laparoscopic cholecystectomy (LC) is conventionally performed under general anesthesia (GA) in our institution. There are multiple studies which have found spinal anesthesia as a safe alternative. The study aimed to evaluate efficacy and advantages of performing laparoscopic cholecystectomy under spinal anesthesia (SA) in comparison to general anesthesia (GA). Fifty patients with symptomatic cholelithiasis and American Society of Anesthesiologists status I or II were randomly allocated to have LC under spinal (n = 25) or general (n = 25) anesthesia. Intra-operative vitals, postoperative pain, complications, recovery, and patient’s satisfaction were compared between the 2 groups. Mean age of the patients was 48 years. Out of the total study participants 10% were males and 90% were females. In the SA group more patients complained of shoulder pain and also there were more incidences of bradycardia and hypotension during intra-operative period in SA group. There was no statistically significant difference in operating time between the two groups. Significantly fewer patients had post-operative vomiting and pain at operated site in the SA group. Gut function returned within 12 hours, restored early in SA group. Port site infection and hospital stay (in days) were also significantly less in SA group as compared to GA group. Laparoscopic cholecystectomy done under spinal anesthesia is feasible and safe. It can be recommended to be the anesthesia technique of choice for conducting laparoscopic cholecystectomy in hospital setups in developing countries where cost factor is a major factor.
Risk of renal stone events in primary hyperparathyroidism before and after parathyroid surgery: controlled retrospective follow up study

Abstract Aim: To study the risk of renal stone episodes and risk factors for renal stones in primary hyperparathyroidism before and after surgery. Design: Register based, controlled retrospective follow up study. Setting: Tertiary hospitals in Denmark. Participants: 674 consecutive patients with surgically verified primary hyperparathyroidism. Each patient was compared with three age- and sex-matched controls randomly drawn from the background population. Hospital admissions for renal stone disease were compared between patients and controls. Risk factors for renal stones among patients were assessed. Main outcome measures: Number of renal stone episodes; comparison of hospital admissions for renal stones in patients and controls; assessment of risk factors for renal stones. Results: Relative risk of a stone episode was 40 (95% confidence interval 31 to 53) before surgery and 16 (12 to 23) after surgery. Risk was increased 10 years before surgery, and became normal more than 10 years after surgery. Stone-free survival 20 years after surgery was 90.4% in patients and 98.7% in controls (risk difference 8.3%, 4.8% to 11.7%). Patients with preoperative stones had 27 times the risk of postoperative stone incidents than controls. Before surgery, males had more stone episodes than females and younger patients had more stone episodes than older patients. Neither parathyroid pathology, weight of removed tissue, plasma calcium levels, nor skeletal pathology (fractures) influenced the risk of renal stones. After surgery, younger age, preoperative stones and ureteral strictures were significant risk factors for stones. Conclusions: The risk of renal stones is increased in primary hyperparathyroidism and decreases after surgery. The risk profile is normal 10 years after surgery. Preoperative stone events increase the risk of postoperative stones. Stone formers and non-stone formers had the same risk of skeletal complications.
Identification of a protein essential for a major pathway used by human cells to avoid UV- induced DNA damage

When DNA replication stalls at a fork-blocking lesion, cells use damage tolerance pathways to continue replication. One pathway, “translesion synthesis,” involves specialized DNA polymerases that can use damaged DNA as a template. Translesion synthesis can result in mutations (i.e., can be error-prone), but it can also be error-free. An alternative pathway has been hypothesized (sometimes called “damage avoidance”), by which cells make temporary use of an undamaged copy of the blocked sequence as a template, i.e., the newly synthesized daughter strand of the sister duplex or the allelic copy. This pathway is error-free. Evidence of the use of the daughter strand of the sister duplex as a template in intact mammalian cells has not been available heretofore. To determine whether hMms2, a ubiquitin-conjugating enzyme-like protein, plays a critical role in such damage avoidance, a human fibroblast cell strain in which both error-prone translesion synthesis and error-free damage avoidance can be detected and quantified simultaneously, and several derivative strains in which expression of hMms2 protein had been eliminated or greatly decreased, were compared for their ability to avoid translesion synthesis past UV254nm-induced DNA photoproducts. Loss of hMms2 protein eliminated the ability of the latter strains to use an allelic copy of a target gene for damage avoidance, i.e., to produce a wild-type gene from two nonfunctional allelic copies of that gene. Molecular analysis of the wild-type gene showed that this process involves gene conversion unassociated with crossing-over. That the loss of hMms2 also eliminated use of the daughter strand of the sister duplex as a template for damage avoidance could be inferred from the fact that the frequency of mutations induced by UV in the single copy HPRT gene of the derivative strains was significantly higher than that observed in the parental strain. These data indicate that hMMS2 is essential for human cells to carry out damage avoidance by using either type of homolog, and that damage avoidance and translesion synthesis are alternative pathways for tolerating fork-blocking photoproducts.
The Dollars and Sense of Ballot Propositions: Estimating Willingness to Pay for Public Goods Using Aggregate Voting Data

This paper develops a new approach for estimating willingness to pay (WTP) for public goods using referendum voting data, and we demonstrate the approach by applying it to a series of referenda in California spanning a wide array of public goods. We find a range of annual WTP values for successful propositions from $3.47 per person for children’s hospitals to $94.48 per person for transportation infrastructure and management. We also impute the per capita cost of each proposition. Comparing these imputed costs to our WTP measure allows us to infer the upper bound on prices that would still ensure passage of a successful measure. Conversely, this comparison provides an estimate of the decrease in prices that would have been necessary to ensure passage of unsuccessful propositions. In addition, we estimate the relative effects of prices, income, and ideology on the support for public goods. We show that both ideology and economic costs have significant impacts, which stands in contrast to previous work that contends that voting patterns are driven purely by fiscal costs.
Implementing Suicide Prevention Programs: Costs and Potential Life Years Saved in Canada.

BACKGROUND Little is known about the costs and effects of suicide prevention programs at the population level. AIMS OF THE STUDY We aimed to determine (i) the costs associated with a suicide death and using prospective values (ii) the costs and effects of transferring, into a Canadian context, the results of the European Nuremberg Alliance against Depression (NAD) trial with the addition of 4 community-based suicide prevention strategies. These included the training of family physicians in the detection and treatment of depression, population campaigns aimed at increasing awareness about depression, the training of community leaders among first responders and follow-up of individuals who attempted suicide. METHODS This study includes a prospective value implementation study design. Using published data and information from interviews with Canadian decision makers, we assessed the costs of a suicide death in the province of Quebec and the costs of potentially implementing the NAD multi-modal suicide prevention programs, and the incremental cost-effectiveness ratio (ICER), from a health care system and societal perspective, associated with the NAD program while considering the friction cost method (FCM) and human capital approach (HCA) (discounted at 3%.) The costs considered included those incurred for the suicide prevention program and direct medical and non-medical costs as well as those related to a police investigation and funeral costs. Indirect costs associated with loss of productivity and short term disability were also considered. Sensitivity analyses were also carried out. Costs presented were in 2010 dollars. RESULTS The annual total cost of implementing the suicide prevention programs in Quebec reached CAD23,982,293. The most expensive components of the program included the follow-up of individuals who had attempted suicide and psychotherapy for bereaved individuals. These accounted for 39% and 34% of total costs. The ICER associated with the implementation of the programs reached on average CAD3,979 per life year saved. DISCUSSION Suicide prevention programs such as the NAD trial are cost-effective and can result in important potential cost-savings due to averted suicide deaths and reduced life years lost. IMPLICATIONS FOR HEALTH CARE PROVISION AND USE Implementation of suicide prevention programs at the population level in Canada is cost-effective. Community mental health programs aimed at increasing awareness and the treatment of depression and better follow-up of high risk individuals for suicide are associated with a minimal per capita investment. These programs can result in important potential cost-savings due to averted suicide deaths and decreased disability due to depression. IMPLICATIONS FOR FURTHER RESEARCH Additional research should focus on whether the outcomes of multi-modal suicide programs are specific or synergistic and most effective for which population subgroups. This may help inform how best to invest resources for the highest return.
Oral health inequalities in preschool children in North-Eastern Italy as reflected by caries prevalence.

AIM To investigate dental caries experience among preschool children aged 3-5 years living in 2 Health Districts in North- Eastern Italy and to compare caries experience between indigenous and immigrant children. STUDY DESIGN Cross-sectional observational survey. METHODS AND STATISTICS: In this study 4,198, 3-5-year-old children, drawn from a total population of 9,829 were asked to participate. The examinations were performed at school between October 2004 and June 2005 and only lesions that penetrate the dentine were recorded (according to the BASCD criteria, 1997), by 2 calibrated examiners using artificial light, mouth mirrors and dental probes. The participants were categorised into 2 subgroups according to the country of origin of their mothers: indigenous mothers, almost all born in Italy, plus a very small number of mothers born in other highly developed western countries--"western origin"--(Nordic countries, Western Europe, North America, New Zealand and Australia), and immigrant mothers from Eastern Europe, Asia, Africa, Turkey, South and Central America, "non-western origin". Comparisons between groups were made using Pearson chi-squared test. Caries risk estimation was established by logistic regression analysis to assess the influence of gender, age and ethnicity on caries experience. Risk was summarised as odds ratio plus 95% CI. RESULTS A total of 3,401 pre-school children were examined. The overall prevalence of dentinal caries was: 15.4% in 3-year-olds, 24.2% in 4-year-olds and 31.1% in 5-year-olds. At the same ages, children of immigrant mothers ("non-western origin") showed a significantly higher prevalence of caries compared with their counterparts of "western origin". As expected, older children had more caries. "Non-western origin" had a negative effect on caries experience. CONCLUSIONS Inequalities associated with mothers with an immigrant background were observed in the distribution of caries experience among the children. These children represent the first generation settling in and growing up in Italy, and their dental status-related data are comparable to those observed at the same ages in first generation "non-western" children living in other industrialised countries.
Wafer-Scale Manufacturing of Bulk Shape-Memory-Alloy Microactuators Based on Adhesive Bonding of Titanium–Nickel Sheets to Structured Silicon Wafers

This paper presents a concept for the wafer-scale manufacturing of microactuators based on the adhesive bonding of bulk shape-memory-alloy (SMA) sheets to silicon microstructures. Wafer-scale integration of a cold-state deformation mechanism is provided by the deposition of stressed films onto the SMA sheet. A concept for heating of the SMA by Joule heating through a resistive heater layer is presented. Critical fabrication issues were investigated, including the cold-state deformation, the bonding scheme and related stresses, and the titanium-nickel (TiNi) sheet patterning. Novel methods for the transfer stamping of adhesive and for the handling of the thin TiNi sheets were developed, based on the use of standard dicing blue tape. First demonstrator TiNi cantilevers, wafer-level adhesively bonded on a microstructured silicon substrate, were successfully fabricated and evaluated. Intrinsically stressed silicon dioxide and silicon nitride were deposited using plasma-enhanced chemical vapor deposition to deform the cantilevers in the cold state. Tip deflections for 2.5-mm-long cantilevers in cold/hot state of 250/70 and 125/28 mum were obtained using silicon dioxide and silicon nitride, respectively. The bond strength proved to be stronger than the force created by the 2.5-mm-long TiNi cantilever and showed no degradation after more than 700 temperature cycles. The shape-memory behavior of the TiNi is maintained during the integration process.
Gender assessment through three-dimensional analysis of maxillary sinuses by means of cone beam computed tomography.

OBJECTIVE The availability of a low dose radiation technology such as Cone Beam Computed Tomography (CBCT) in dental practice has increased the number of scans available for forensic purposes. Moreover, specific software allows for three-dimensional (3D) characterization of the maxillary sinuses. This study was performed to determine whether sinus maxillary volumes can be useful to identify gender after validating the use of the Dolphin software as a tool for volumetric estimation of maxillary sinus volumes. PATIENTS AND METHODS The validation was performed by four different operators measuring the volume of six phantoms, where the real volume was already known. The maxillary sinus volumes of 52 patients (26 males and 26 females) mean age 24.3 were calculated and compared between genders and sagittal skeletal class subdivision. The measurements for patients and phantoms were based on CBCT scans (ILUMA™) processed by Dolphin 3D software. RESULTS No statistical difference was observed between the real volume and the volume measurements performed by the operators. No statistical difference was found in patient's maxillary sinus volumes between gender. CONCLUSIONS Based on our results, it is not possible to support the use of maxillary sinuses to discern sexual difference in corpse identification.
A review of unusual species of Cotesia (Hymenoptera, Braconidae, Microgastrinae) with the first tergite narrowing at midlength

Abstract The unusual species of Cotesia (Hymenoptera, Braconidae, Microgastrinae) with the first tergite narrowing at midlength are reviewed. One new species, Cotesia trabalae sp. n. is described from India and compared with Cotesia pistrinariae (Wilkinson) from Africa, the only other species sharing the same character of all the described species worldwide. The generic placement of these two species, based on molecular and morphological analyses as well as parasitoid biology is discussed.
Pediatric Rhabdomyosarcomas Express the Intermediate Filament Nestin

Previous findings that the intermediate filament nestin is expressed in immature skeletal muscle cells prompted us to compare the staining patterns of nestin and desmin in rhabdomyosarcomas (RMSs) and in other small cell tumors of infancy. We found that nestin immunoreactivity was present in all of 29 examined typical RMSs, which also expressed desmin. Two undifferentiated tumors, primarily suspected to be RMSs, expressed nestin, but not desmin. One of these nestin-positive, desmin-negative tumors was positive for the expression of the myogenic regulatory gene MyoD and is considered to represent an undifferentiated RMS. The other, a paratesticular tumor, did not contain transcripts for MyoD, and most likely does not represent a RMS. In several RMSs and nonmuscle tumors, a z-disc-associated nestin immunoreactivity occurred as a paramalignant phenomenon in cross-striated muscle fibers adjacent to the tumor cells. Our findings indicate that nestin, although present also in tumors of the central and peripheral nervous systems, as well as in endothelial cells and in some muscle cells adjacent to tumors, is a useful complementary marker for RMS, particularly in very undifferentiated desmin-negative tumors.