Miracle-dz/UniFAR-FTUs huggingface dataset:
Haemodynamic influences on kidney oxygenation: Clinical implications of integrative physiology

Renal blood flow, local tissue perfusion and blood oxygen content are the major determinants of oxygen delivery to kidney tissue. Arterial pressure and segmental vascular resistance influence kidney oxygen consumption through effects on glomerular filtration rate and sodium reabsorption. Diffusive shunting of oxygen from arteries to veins in the cortex and from descending to ascending vasa recta in the medulla limits oxygen delivery to renal tissue. Oxygen shunting depends on the vascular network, renal haemodynamics and kidney oxygen consumption. Consequently, the impact of changes in renal haemodynamics on tissue oxygenation cannot necessarily be predicted intuitively and, instead, requires the integrative approach offered by computational modelling and multiple measuring modalities. Tissue hypoxia is a hallmark of acute kidney injury (AKI) arising from multiple initiating insults, including ischaemia–reperfusion injury, radiocontrast administration, cardiopulmonary bypass surgery, shock and sepsis. Its pathophysiology is defined by inflammation and/or ischaemia resulting in alterations in renal tissue oxygenation, nitric oxide bioavailability and oxygen radical homeostasis. This sequence of events appears to cause renal microcirculatory dysfunction, which may then be exacerbated by the inappropriate use of therapies common in peri‐operative medicine, such as fluid resuscitation. The development of new ways to prevent and treat AKI requires an integrative approach that considers not just the molecular mechanisms underlying failure of filtration and tissue damage, but also the contribution of haemodynamic factors that determine kidney oxygenation. The development of bedside monitors allowing continuous surveillance of renal haemodynamics, oxygenation and function should facilitate better prevention, detection and treatment of AKI.
Altered Steroid Metabolism and Insulin Signaling in PCOS Endometria: Impact in Tissue Function.

BACKGROUND Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine/ metabolic disorder characterized by hyperandrogenemia and in most cases, by hyperinsulinemia in addition to obesity. Besides ovarian dysfunction, endometrial physiology is also disrupted since this tissue is highly dependent on the action of steroids; in case of conception cycles, high percentage of abortion is observed. Because of the endocrine/metabolic alterations, PCOS-women present high probability to develop hyperplasia and endometrial cancer, where an imbalance of cell proliferation/apoptosis processes is detected. Additionally, insulin pathway and the endometrial energetic homeostasis are also compromised. METHODS The aim of this review was to report molecular alterations related to insulinresistance and/or obesity in PCOS-women endometria that could drive to infertility. For this, several methods were employed: immunohistocytochemistry, qPCR, western-blot, glucoseuptake, cell cultures, among others. RESULTS Diminished levels and activity of several insulin signaling pathway molecules, like IRS-1/AS160/PKCζ, were detected. Concomitantly, a defect in the synthesis and GLUT4 translocation to cell surface is induced. Oral administration of metformin (insulin sensitizer) to PCOS-patients increases GLUT4 endometrial levels, improving fertility of those patients. Another relevant feature is the high percentage of obesity in PCOS-women; adiponectin is an obesity marker and elicits an insulin-sensitizer action, being diminished in plasma of obese PCOSwomen similar to its endometrial level, adiponectin-receptors and APPL1, an adapter molecule of adiponectin pathway. Moreover, obesity and PCOS can induce a pro-inflammatory environment, exaggerating the alterations in insulin pathway. CONCLUSION The evidences obtained in PCOS-endometria clearly indicate that these molecular defects could partially explain the reproductive failures of these patients.
Determinants of Location for General Purpose Office Firms within Medium Size Cities

This study examines determinants of the downtown/non-downtown location choice for general purpose rental office users. It presents a model of location choice which accounts for linkages, personnel commuting costs and location of market centroid. It fits the model to survey data on office space usage, distinguishing between market oriented and non-market oriented firms.The study finds that market oriented firms are primarily sensitive to market location, while non-market oriented firms are more sensitive to linkages and personnel commuting costs. It also finds that linkages play a limited role in the location decisions even for non-market oriented offices because, in the medium size cities studied, few firms are linkage intensive. Copyright American Real Estate and Urban Economics Association.
Retirement saving and mental health in China

The Chinese population is aging rapidly while both the pension system is underdeveloped and the traditional family care arrangement is in retreat. This article's objective is to assess the relationship between concerns over retirement saving sufficiency and the mental health status of middle-aged and older Chinese adults, and identify the socioeconomic and demographic profile of those with insufficient retirement savings. A survey from about 2000 respondents collected information on self-assessed physical and mental health status based on the EQ-5D-5L framework, self-assessed longevity, retirement plans and financial preparedness and socioeconomic status. Multivariate ordered logistic regressions are used to identify the relationship between mental health status, financial preparedness for retirement and self-assessed longevity, as well as socioeconomic factors associated with mental health status and financial preparedness for retirement respectively. It is found that 59% of the respondents thought that they have not saved, or will not be able to save enough for their retirement. For these people, the odds of having less anxiety or depression are 0.36 (95% CIs: 0.16-0.43) times lower than those who are financially prepared. Having more external sources of financial assistance including family and governments, did not help ease mental distress. Rural people are half as likely to be financially prepared for retirement, regardless of whether they remain in rural areas or migrate to cities. Health promotion strategies should consider the role for financial planning in improving mental health.
Pregnancy outcome in systemic lupus erythematosus complicated by anti-phospholipid antibodies.

OBJECTIVE Pregnant women affected by SLE are at high risk of gestational hypertension and pre-eclampsia (32-50%). This risk is particularly elevated if aPLs are dosable. The present study was planned to evaluate maternal-fetal outcomes of different groups of SLE pregnant patients characterized by diverse risk factors: patients affected by APS treated with a combination of low-dose aspirin (LDA) and low-molecular weight heparin (LMWH), nulliparous patients with dosable aPL treated by LMWH and SLE patients with no aPL administered no treatment during pregnancy. METHODS A retrospective description of maternal and fetal outcomes was made in a total of 62 pregnancies presenting APS in 8 cases (12.9%), aPL in 20 (32.2%) and no aPL in 34 (54.8%). RESULTS No statistically significant difference was found comparing fetal and maternal outcomes of the three groups despite differences in SLE activity: SLE aPL-positive pregnancies were associated with a higher incidence of nephritis and chronic hypertension than pregnancies treated for APS or not presenting with the added risk factor. The incidence of pre-eclampsia is 15% in aPL positive, 12.5% in APS and 14.7% in no aPL pregnancies, respectively. CONCLUSIONS LMWH is rather a possible option of prophylaxis for SLE aPL-positive pregnancies with potential maternal-fetal outcomes similar to aPL-negative patients or to standard treated APS.
Return to work after stroke: The KOSCO Study.

OBJECTIVE To investigate the return to work status of patients with first-ever stroke with functional independence 6 months post-stroke. DESIGN Prospective cohort study. PARTICIPANTS Nine hundred and thirty-three patients with functional independence at 6 months after stroke onset. METHODS A complete post-enumeration survey was performed through a review of the medical records for first admission. In addition, structured self-administered questionnaires and a face-to-face interview were performed assessing occupational status, quality of life, and emotional status at 6 months after stroke. RESULTS Of the patients in this study, 60.0% returned to work at 6 months after stroke. Sex, age, educational level, and comorbidity level were independent factors related to return to work. The rate of return to work in female patients under 65 years of age was similar to that of male patients 65 years of age or older. Stroke patients who returned to work showed better emotional statuses than those who did not return to work. CONCLUSION Many stroke patients did not return to work despite functional independence at 6 months after stroke. Based on the results of this study, we suggest providing appropriate vocational rehabilitation for stroke patients and proper education for employers to increase the rate of early return to work in stroke patients.
Splicing Factor Spf30 Assists Exosome-Mediated Gene Silencing in Fission Yeast

ABSTRACT Heterochromatin assembly in fission yeast relies on the processing of cognate noncoding RNAs by both the RNA interference and the exosome degradation pathways. Recent evidence indicates that splicing factors facilitate the cotranscriptional processing of centromeric transcripts into small interfering RNAs (siRNAs). In contrast, how the exosome contributes to heterochromatin assembly and whether it also relies upon splicing factors were unknown. We provide here evidence that fission yeast Spf30 is a splicing factor involved in the exosome pathway of heterochromatin silencing. Spf30 and Dis3, the main exosome RNase, colocalize at centromeric heterochromatin and euchromatic genes. At the centromeres, Dis3 helps recruiting Spf30, whose deficiency phenocopies the dis3-54 mutant: heterochromatin is impaired, as evidenced by reduced silencing and the accumulation of polyadenylated centromeric transcripts, but the production of siRNAs appears to be unaffected. Consistent with a direct role, Spf30 binds centromeric transcripts and locates at the centromeres in an RNA-dependent manner. We propose that Spf30, bound to nascent centromeric transcripts, perhaps with other splicing factors, assists their processing by the exosome. Splicing factor intercession may thus be a common feature of gene silencing pathways.
Technical progress and maturity in a Kaleckian model of growth with an endogenous employment rate

We develop a Kaleckian model of growth with an endogenous employment rate and investigate the features following Cassetti(2003) which has considered bargaining power of workers and firms and technical progress. We assume that both of the target wage share and the technical progress depend on the rate of change of employment rate, and they become zero in steady state. We also assume that capital accumulation is a decreasing function in employment to consider maturity which defines the present capitalism society. From the above refinements, we get results different from Cassetti(2003). An increase in the saving rate does not make the growth rate decrease, but the utilization decrease. In addition to that, an increase in the rate of labor productivity exerts a positive impact on growth.
Dividends, Share Repurchases, and Tax Clienteles: Evidence from the 2003 Reductions in Shareholder Taxes

This paper jointly evaluates firm-level changes in investor composition and shareholder distributions following a 2003 reduction in the dividend and capital gains tax rates for individuals. We find that directors and officers, but not other individual investors, rebalanced their portfolios to maximize after-tax returns in light of the new tax rules. We also find that firms adjusted their distribution policy (specifically, dividends versus share repurchases) in a manner consistent with the altered tax incentives for individual investors. To our knowledge, this is the first paper to employ simultaneous equations to estimate both investor and managerial responses to the 2003 rate reductions. We find that estimating a system of equations leads to different inferences.
What is the future of assertive community treatment?

Although the trend towards community care for psychiatric patients has been apparent now for over fifty years, we still do not have a satisfactory model of community care that all can aim for as the target to be achieved. To an outsider this may seem curious. It seems fairly obvious that hospitals are necessary for patients when they are severely ill, that good care given outside hospital when patients have made some improvement is better than continued hospital treatment, and that the more resources there are available in the community to treat patients early in the course of illness or at times of relapse, the better the service. When one learns that by far the largest proportion of costs spent on the treatment of mental illness is concerned with in-patient treatment (around 85% in most countries) (Knapp et al., 1994), it is also easy to see why such a policy is attractive to planners and managers of mental health services as well as governments who have to foot the bills.
Moving Targets

After 10 years of controversial negotiations, in 1996 the European Union finally took action to liberalize the electricity supply industry. Given the intensity of bilateral contacts between France and Germany, the reform has often been presented as a straightforward intergovernmental deal. This article argues that the French-German deal was only the tip of the iceberg. Perceptions of national interests evolved considerably in both countries. The most important cause for these changes was at the European Union (EU) level, not at the national level. The institutional dynamics of EU negotiations induced a series of preference changes and key political realignments at the national level.
Innovation and Dominant Design in Mobile Telephony

We document the evolution of product innovation and features in the mobile telephone handset market. We distinguish between two types of product innovation: vertical and horizontal innovation. Using data on mobile telephone handsets from 1990 to 2003, we study the emergence of a dominant design in vertical and horizontal innovations and find that, while vertical product characteristics converged to some extent, no dominant design emerged. For horizontal product characteristics, some horizontal innovations remained differentiated, whereas others were adopted in all new handset models, thus forming a dominant design in horizontal product features. We explain this pattern using the concept of dominant design and results from the theoretical literature on the incentives for horizontal and vertical differentiation.
LABOUR SUPPLY ESTIMATION AND PUBLIC POLICY

Abstract. Economists devote considerable energies towards refining their econometric techniques to overcome difficulties connected with conducting empirical research. Despite advances in technique. it is not clear whether further refinement in this direction is worthwhile for policy purposes. It may be that no further amount of statistical adjustment of inadequate data will increase understanding, and that better data is simply necessary to add to our knowledge. But rarely is sufficient credit paid to new forms of data. In short, econometric technique is emphasized to the neglect of data innovation, as if new data were merely lying about waiting for an ingenious suggestion for use. This paper surveys advances of the last twenty five years in estimating labour supply for policy purposes with a view towards appreciating the relative contribution of both improvements in econometric technique as well as developments of new data. After briefly detailing the key parameters which economists have sought to estimate, we describe the early ‘first generation’ research (circa 1970), which is plagued by problems of unobservable variables, measurement errors, truncation and selectivity bias, and non linear budget constraints. ‘Second generation’ research constitute attempts to resolve one or more of these difficulties, and the respective contribution of econometric technique and new data is acknowledged and assessed, including the contribution of data generated by large scale social experiments in which participants are randomly assigned to different guaranteed income plans and their labour supply behaviour measured.
Input Trade Liberalization and Wage Inequality: Firm-Level Evidence from China

Whether China’s accession to the WTO has exacerbated or mitigated the wages gap? Yet there is neither theoretical consensus nor consistent empirical evidences. In this paper, we …rst extend Bernard et al.’s (2007) model and show that input trade liberalization in an unskilled labor abundant country such as China could reduce wages gap between the skilled labor and unskilled labor. We then provide rich empirical exercises to con…rm such a theoretical conjecture. After controlling for various …rm characteristics such as …rm size, productivity and trading partners’ trade liberalization, our rich empirical investigations con…rm that a fall in input trade costs will
Group Size and Performance: Prediction of Failure by Loan Officers

This paper begins by replicating the Libby and Blashfield (1978) experiment for the business failure task. The investigation is then extended to consider a non–unit weighted decision scheme modelling differential task expertise among group members. In this case, the results of the study suggest that the use of groups with more than three members can be justified.
From Ivory Towers to International Business

The main hypothesis examined in this study is that the success of export recruitment strategies of universities is partly determined by their export readiness, defined as a function of market orientation. This article seeks to fulfil both a research and a practitioner gap in the export of education field. There currently exists a lack of research and discussion concerning the business aspects of export education. Suspicion of the commercial aspects of what is essentially a public good is suggested as a possible reason for this absence of research. With the commercialisation of education growing at the phenomenal rate that it currently is, it is largely time that this research gap be addressed. This study provides an important contribution by examining the export readiness of universities, in particular pre-export market orientation, and its impact on subsequent export recruitment performance.
Nutrient cycling and N2O emissions in a changing climate: the subsurface water system role

This study has quantified the subsurface (groundwater, soil, sediment) water system role for hydrological nitrogen (N) and phosphorus (P) loading to the coast and agricultural N2O emissions to the atmosphere in a changing climate. Results for different climate and hydrological model scenarios in the Swedish Norrström drainage basin show that the subsurface water system may largely control a long-term increase in the coastal nutrient loading, in particular for P, irrespectively of the realized future climate change scenario and our uncertainty about it and its water flow effects. The results also indicate an important subsurface water system role for current atmospheric N2O emissions from agriculture, and an even greater role for future ones. The current N2O–N emissions from agriculture are quantified to be about 0.05 g m−2 yr−1 over the basin surface area, or 3% of the direct N mass application on the agricultural land. These results are consistent with recent global emission estimates, and show how the latter can be reconciled with previous, considerably smaller subsystem emission estimates made by the IPCC (Intergovernmental Panel on Climate Change).
Thoracic electrical bioimpedance measurement of cardiac output in postaortocoronary bypass patients

ObjectiveTo assess the degree of correlation and agreement between cardiac output by thermodilution and bioimpedance using the BoMed NCCOM3-R7 monitor in postaortocoronary bypass patients. DesignProspective, randomized sampling. SettingMilitary teaching hospital intensive care unit. PatientsFifty patients undergoing coronary artery bypass surgery with thermodilution pulmonary artery catheters in place. Simultaneous determination of cardiac output by thermodilution and thoracic bioimpedance was performed. Readings were taken between 8 and 24 hrs after surgery. Forty patients were intubated; 19 patients had left-sided tube thoracotomy in addition to two mediastinal tubes, and 19 patients were obese. InterventionsNone. Measurements and Main ResultsThe overall degree of correlation between the two measures was fair (r2 = .24). The bias and precision measurements were inaccurate as well (-0.33 ± 3.14). Patients with normal body habitus or who were not receiving mechanical ventilation showed the best correlation (r2 = .40 and r2 = .45, respectively). Only 62% (31/50) of all patients had simultaneous measurements fall within 20% of each other, and there were no clinical features that made identification of those patients possible. ConclusionsUse of the BoMed NCCOM3-R7 bioimpedance monitor as a replacement for thermodilution-derived cardiac output cannot be recommended in postaortocoronary bypass patients. The distortions of patients' normal anatomy and physiology, coupled with the presence of endotracheal tubes and mechanical ventilation, mediastinal tubes and chest tubes, result in only fair correlation, significant bias, and poor precision between the two measures of cardiac output. (Crit Care Med 1993; 21:1139–1142)
An exploration of the service orientation discrepancy phenomenon in a public sector context

This article explores the nature, antecedents and consequences of a potential service orientation discrepancy in a UK public sector setting. The quantitative and qualitative data collected suggest that: (1) similar to the private sector, employees perceive a discrepancy between their own service orientation and that of the organisation; (2) the antecedents for this discrepancy differ from the private sector: employees' commitment to help communities contrasts with Modernising Government efforts to drive efficiency while neglecting effectiveness; (3) emphasising the development of tailored and proactive services may reduce the service orientation discrepancy and thus improve service performance and job satisfaction.
“Once-off” and Continuing Gains from Trade

Most economists are familiar with the static or "once-off" welfare gains created by opening an economy to trade. Much less is known about how the resource reallocations necessitated by this move affect long-run growth, and hence whether they provide dynamic or continuing welfare gains in future periods. This paper employs a dynamic Ricardian trade model to provide a decomposition of the gains from trade into "once-off" and continuing categories. In one version of the model, trade is always welfare enhancing; in the other, "once-off" losses may occur alongside dynamic gains. In both versions the magnitude of "once-off" and continuing effects are related to absolute and relative country size, similarity in production structures, rates of time preference, and the productivity of R&D.