Miracle-dz/UniFAR-FTUs huggingface dataset:
[Osteoporosis impairs fracture healing of tibia in a rat osteoporotic model].

OBJECTIVE To evaluate the influence of osteoporosis on fracture healing. METHODS Eighty-four 4 months old female Sprague-Dawley rats were randomly divided into osteoporosis (OP) group and sham operation (SO) group, 42 in each. Rats in OP group were performed ovariectomy operation while those in SO group with sham operation. When osteoporosis formed 10 weeks after ovariectomy, midshaft tibia fracture model was established. Tibias were harvested 2 weeks (2 rats per group), 4 weeks (9 rats per group), 6 weeks (9 rats per group), 12 weeks (9 rats per group) and 18 weeks (7 rats per group) after fracture for bone mineral density (BMD), histomorphological and biomechanical evaluation. RESULTS Compared with the SO group: (1) Callus BMD was significantly lower about 12.8%, 18.0%, 17.0% in OP group 6, 12, 18 weeks after fracture, respectively (P < 0.05). (2) Callus failure load was significantly lower about 24.3%, 31.5%, 26.6%, 28.8% in OP group, and callus failure stress was also significantly lower about 23.9%, 33.6%, 19.1%, 24.9% in OP group 4, 6, 12, 18 weeks after fracture, respectively (P < 0.05). (3) In OP group, endochondral bone formation was delayed, more osteoclast cell could be seen around the trabecula, and the new bone trabecula arranged loosely and irregularly. CONCLUSION Osteoporosis influences the middle and late periods of fracture healing in the rat osteoporostic model. The impairment is considered to be the result of the combined effects of the prolonged endochondral calcification, high activated osteoclast cell and the deceleration of the increase in bone mineral density.
The failure of risk management for nonfinancial companies in the context of the financial crisis: lessons from Aracruz Celulose and hedging with derivatives

The main contribution of this article is to present hard evidence on hedging strategies and relate it to behavioural and agency problems resulting from speculation with derivatives. We focus on the case of Aracruz Celulose. We show how the real hedge position of Aracruz – that lost US2.1 billion in currency derivatives – deviated from its optimal hedge as the result of speculation with Over-the-Counter (OTC) derivatives.
Relationships between spectral optical properties and optically active substances in a clear oligotrophic lake

The absorption and scattering coefficients in the euphotic zone of oligotrophic Lake Taupo, New Zealand, were measured at 19 stations across the 620 km2 lake in late fall during the period of mixed layer deepening and development of the annual phytoplankton maximum. These coefficients were subsequently related to the water content of colored dissolved organic matter (CDOM), phytoplankton, and nonalgal particles via measurements of the absorption spectra of these optically active substances and of chlorophyll a and suspended particle concentrations. Measurements of the spectral diffuse attenuation coefficient for downwelling irradiance (Kd) and of reflectance (Lu/Ed) revealed that the clear blue waters of Lake Taupo had a minimum Kd of 0.09 m−1 at 500 nm and maximum reflectance at 490 nm. The measured Kd and Lu/Ed were well described by modeled spectra that were computed using a radiative transfer model (Hydrolight) assuming relatively low values for the backscattering ratio (0.008–0.014). The relationships established here between the optical properties and optically active substances were consistent with previous observations in case 2 marine waters, and they will provide a basis for prediction of eutrophication, climate, and other environmental effects on the blueness and transparency of large oligotrophic lakes.
Expression and growth‐promoting effect of adult t‐cell leukemia‐derived factor a human thioredoxin homologue in hepatocellular carcinoma

Adult T‐cell leukemia‐derived factor (ADF), originally defined as an interleukin‐2 receptor inducer, is a human thioredoxin homologue. ADF is detected in many malignant tissues and has a growth‐promoting effect on transformed cells. In this study, ADF expression was examined immunohistochemically in human liver cell lines and liver tissues, and its growth‐promoting effect was tested on human hepatoma cells. On three liver cell lines—PLC/PRF/5, HepG2, and Chang liver cells—ADF stained positively and also was detected by immunoblotting. ADF had strong staining in the fetal liver (n = 8), although it was faint in the normal adult liver (n = 6). In hepatocellular carcinoma (n = 25), ADF expression generally was enhanced and was very strong in 52% (13 of 25) of the cases, although it was moderate in cases of chronic hepatitis or cirrhosis. ADF augmented the growth of PLC/PRF/5 cells and showed an additive effect with epidermal growth factor. These results indicate possible involvement of ADF in cell activation and growth of hepatocytes, as is the case with lymphocytes.
Electrophysiological responses of single olfactory bulb neurons to binary mixtures of amino acids in the channel catfish, Ictalurus punctatus.

1. For the first time in any vertebrate, responses of single olfactory bulb neurons to odorant mixtures were studied quantitatively in the channel catfish, Ictalurus punctatus. 2. Extracellular electrophysiological responses of 61 single olfactory bulb neurons from 36 channel catfish to binary mixtures of amino acids and to their components were recorded simultaneously with the electro-olfactogram (EOG). Tested were a total of 297 mixture trials consisting of 18 different stimulus pairs formed from 8 amino acids. 3. For 42% (126 of the 297) of the tests, no significant change (N) from spontaneous activity occurred. Responses to the remaining 171 tests of binary mixtures were excitatory (E; 29%) or suppressive (S; 29%). No response type was associated with any specific mixture across the neurons sampled. 4. Mixture interactions that changed response types (E or S) from those observed to the individual components were rare, because 89% of the responses of single olfactory bulb neurons to the tested binary mixtures were classified similarly as the responses to at least one of the components. 5. Responses of single olfactory bulb neurons were generally predictable for binary mixtures whose component responses were classified as both E, both S, and both N. For binary mixtures whose component responses were classified differently (e.g., one component evoked excitatory responses and the other evoked suppressive responses), the predictability of the response was dependent on the specific mixture type.
Lemons in the Used Car Market: An Empirical Investigation

This paper uses a modified version of the Bond (1982) lemon model to test the hypothesis that there is no difference in the average maintenance expenditures required for cars acquired used and those acquired new. The author used tobit and logit models to deal with the censoring problem in the data and applied a sensitivity analysis to check the robustness of the coefficients. The data for this study were collected from “The Panel Study of Income Dynamics (PSID)” from the University of Michigan. The results showed no evidence that cars acquired used required more maintenance expenditures than those of a similar age acquired new. The paper further examines the possible impacts of leasing and Certified Pre-Owned programs on the information mechanism and average quality of traded cars. The study found that these institutions have substantially improved the information mechanism between buyers and sellers, which, in turn, has helped reduce adverse selection and improve the average quality of traded cars in the used car market.
Relationship of Cues to Assessed Infant Pain Level

Cues that 46 pediatric nurses with a BS in Nursing reported as key to their pain assessments of 88 videotaped infants, ages 0 to 12 months, are identified. Frequencies with which these cues were used for infants of different ages and the relationships between key cues and assessed levels of pain are described. Greater pain was strongly associated with tears, stiff posture, guarding, and fisting. Greater pain was moderately associated with inadequate type or dosage of analgesia, more recent surgery, Inconsolability, difficult to distract, does not focus on surroundings, frown, grimace, wrinkled face, flushed face, pain cry, and increased arousal in response to touch of sore area. Internurse variability in cue use was sizable. Most of the often-used cues had weak or no association with assessed pain level Only consolability, pain cry, grimace, and stiff posture were frequently used and correlated> . 51 with assessed level of pain.
Correction to "An improved parameterization for sulfuric acid/water nucleation rates for tropospheric and stratospheric conditions"

[1] In this paper we present parameterized equations for calculation of sulfuric acid– water critical nucleus compositions, critical cluster radii and homogeneous nucleation rates for tropospheric and stratospheric conditions. The parameterizations are based on a classical nucleation model. We used an improved model for the hydrate formation relying on ab initio calculations of small sulfuric acid clusters and on experimental data for vapor pressures and equilibrium constants for hydrate formation. The most rigorous nucleation kinetics and the thermodynamically consistent version of the classical binary homogeneous nucleation theory were used. The parameterized nucleation rates are compared with experimental ones, and at room temperature and relative humidities above 30% they are within experimental error. At lower temperatures and lower humidities the agreement is somewhat poorer. Overall, the values of nucleation rates are increased compared to a previous parameterization and are within an order of magnitude compared with theoretical values for all conditions studied. The parameterized equations will reduce the computing time by a factor 1/500 compared to nonparameterized nucleation rate calculations and therefore are in particular useful for large-scale models. The parameterized formulas are valid at temperatures between 230.15 K and 305.15 K, relative humidities between 0.01% and 100%, and sulfuric acid concentrations from 10 to 10 cm . They can be used to extrapolate the classical results down to 190 K. The parametrization is limited to cases where nucleation rates are between 10 7 and 10 cm s , and the critical cluster contains at least four molecules.
Evidence for Acquisition of Legionella Type IV Secretion Substrates via Interdomain Horizontal Gene Transfer

ABSTRACT Intracellular pathogens exploit host cell functions to create a replication niche inside eukaryotic cells. The causative agent of Legionnaires' disease, the γ-proteobacterium Legionella pneumophila, resides and replicates within a modified vacuole of protozoan and mammalian cells. L. pneumophila translocates effector proteins into host cells through the Icm-Dot complex, a specialized type IVB secretion system that is required for intracellular growth. To find out if some effector proteins may have been acquired through interdomain horizontal gene transfer (HGT), we performed a bioinformatic screen that searched for eukaryotic motifs in all open reading frames of the L. pneumophila Philadelphia-1 genome. We found 44 uncharacterized genes with many distinct eukaryotic motifs. Most of these genes contain G+C biases compared to other L. pneumophila genes, supporting the theory that they were acquired through HGT. Furthermore, we found that several of them are expressed and up-regulated in stationary phase in an RpoS-dependent manner. In addition, at least seven of these gene products are translocated into host cells via the Icm-Dot complex, confirming their role in the intracellular environment. Reminiscent of the case with most Icm-Dot substrates, most of the strains containing mutations in these genes grew comparably to the parent strain intracellularly. Our findings suggest that in L. pneumophila, interdomain HGT may have been a major mechanism for the acquisition of determinants of infection.
Comparative Genomics Assisted Functional Characterization of Rahnella aceris ZF458 as a Novel Plant Growth Promoting Rhizobacterium

Many Rahnella strains have been widely described as plant growth-promoting rhizobacteria with the potential to benefit plant growth and protect plants from pathogens. R. aceris ZF458 is a beneficial plant bacterium isolated from swamp soil with the potential for biocontrol. Strain ZF458 has shown broad-spectrum antagonistic activities against a variety of plant pathogens and exhibited a dramatic effect on controlling Agrobacterium tumefaciens in sunflowers. The R. aceris ZF458 genome sequence contained a 4,861,340-bp circular chromosome and two plasmids, with an average G + C content of 52.20%. Phylogenetic analysis demonstrated that R. aceris ZF458 was closely related to R. aceris SAP-19. Genome annotation and comparative genomics identified the conservation and specificity of large numbers of genes associated with nitrogen fixation, plant growth hormone production, organic acid biosynthesis and pyrroloquinoline quinone production that specific to benefiting plants in strain ZF458. In addition, numerous conserved genes associated with environmental adaption, including the bacterial secretion system, selenium metabolism, two-component system, flagella biosynthesis, chemotaxis, and acid resistance, were also identified in the ZF458 genome. Overall, this was the first study to systematically analyze the genes linked with plant growth promotion and environmental adaption in R. aceris. The aim of this study was to derive genomic information that would provide an in-depth insight of the mechanisms of plant growth-promoting rhizobacteria, and could be further exploited to improve the application of R. aceris ZF458 in the agriculture field.
Is blind channel estimation feasible in mobile communication systems? A study based on GSM

We compare the effect of blind and nonblind channel estimates on the performance of Global System for Mobile communications (GSM) receivers. More precisely, we investigate whether two blind approaches, based on higher order statistics (HOS), can compete with two conventional methods, exploiting training sequences. For blind and nonblind estimates of six fast and slowly fading mobile radio channels, we give simulated bit error rates (BERs), after Viterbi detection, in terms of the signal-to-noise ratio (SNR). We also study the influence of cochannel interferers at different values of the signal-to-interference ratio (SIR). Averaged over the six channel examples, we demonstrate that the blind channel estimation algorithm eigenvector approach to blind identification (EVI) leads to an SNR loss of 1.2-1.3 dB only, while it saves the 22% overhead in GSM data rate caused by the transmission of training sequences. Since just 142 samples are used for blind channel estimation, we consider this performance outstanding for an approach based on HOS.
Puberty in a case with novel 17-hydroxylase mutation and the putative role of estrogen in development of pubic hair.

OBJECTIVE 17-Hydroxylase/17,20-lyase deficiency (17OHD) results from mutations in the CYP17A1 gene, leading to failure to synthesize cortisol, adrenal androgens, and gonadal steroids. Adrenarche is a consequence of the increased production of adrenal androgens. Here, we report a case carrying novel R239Q mutation causing complete functional loss of CYP17A1, and thus absence of adrenal and gonadal sex hormone production. The patient has had unexpected pubic hair development and insufficient breast development with estrogen replacement therapy. Possible mechanisms leading to pubic hair development and breast underdevelopment are discussed. PATIENT AND METHODS A 15-year-old female born to consanguineous parents presented with the lack of full breast development and irregular menses after the age of 14 years. She had Tanner III breast development on one side, Tanner I on the other side and Tanner I pubic hair and, no axillary hair development. The serum levels of FSH, LH, and progesterone were high and, estradiol was low. The measurement of basal and ACTH-stimulated steroids was consistent with the diagnosis of 17OHD. Genetic analysis revealed novel homozygous mutation R239Q in CYP17A1 gene. Therapy with hydrocortisone was initiated and followed by the addition of conjugated estrogen. Her breast development did not improve considerably, however, pubic hair development started after estrogen treatment in spite of undetectable serum levels of androgens. CONCLUSION This case study suggests that estrogen exerts a permissive effect on pubic hair development in girls, even in the presence of very low-circulating androgens, and impaired breast development might be due to estrogen/progesterone imbalance in breast tissue.
The use of corticosteroids in Swedish palliative care

Corticosteroids are commonly used in patients with advanced cancer on both specific and non-specific indications. They are potent drugs with potentially serious adverse side effects. We have in two separate surveys collected answers from 302 physicians and data from 1292 patients on corticosteroid prescription attitudes and clinical practice in Swedish palliative care. Corticosteroids were used in more than 50% of the cancer patients and with high response rates when treating appetite loss, nausea, fatigue or poor wellbeing. The positive response came within the first week of treatment and persisted beyond four weeks. Patients with prostate cancer had a significantly better treatment response of corticosteroids on fatigue as compared to patients with lung cancer. Few physicians had guidelines on the use of corticosteroids in advanced cancer and there were differences in the attitudes between different medical specialties. Guidelines based on prospective clinical trials are needed.
Personality and Verbal Conditioning

The verbal conditioning method described by Taffel (7) was used. On the centre of each 3-in. by 5-in. white, unlined card was a verb in the simple past tense. Below the verb in one line were pronouns 'I,' 'WE,' 'SHE,' 'HE,' 'THEY,' 'YOU' in block capitals. There were 80 different orders of the six pronouns and no two cards had the same order of pronoun or the same verb. S was instructed to make a sentence beginning with any one of the pronouns and including the verb at the top. During the first 20 trials (1 to 20 cards), reinforcement was given on two occasions only (8th and 16th cards). This was done so that the first reinforcement after 20 rrials would not be such a surprise to S (5). In the absence of experimental treatment, the first 20 trials served as an operant base. Each S served as his own control for the Block I trials (1 to 20). The remaining trials (21 to 80) which were divided into blocks of 20 (11, 111, IV) were acquisition blocks. Whenever S started a sentence with either 'I' or 'WE' E said "Good" in what E considered a flat, unemotional tone. There was no significant difference in conditioning between groups (t = .435, df = 18, p > .05). The mean percentage over 60 acquisition trials for extraverted groups was 52.4 and for introverted group 41.6. These results do not support the hypothesis that verbal conditioning is related to introversion-extraversion. Extraversion score bore no relation to performance; if anything, the relationship between extraversion and conditioning was the converse of that predicted. There was a slight, but statistically non-significant trend for those high on extraversion to show more
Moderating Effects of Trait Anxiety on Electrodermal Reactions in Different Learning Conditions

This study examined the control of the effects of trait anxiety on GSR during a problem-solving task under different conditions. Of 84 subjects, 39 men and 49 women of mean age 21 yr. , 42 were classified as high in anxiety, 42 as low in anxiety. Subjects solved concept-formation tasks at different degrees of difficulty under one of three learning conditions. Low tone, unpleasant loud tone, and unpleasant electric shock provided the three kinds of error feedback. For the ‘low tone’ and ‘electric shock’ as feedback on errors significant differences in GSR values resulted for groups high and low in anxiety with the latter showing higher scores. The relevance of physiological patterns in multidimensional activation theories for research on anxiety is discussed.
Analyzing language samples of Spanish–English bilingual children for the automated prediction of language dominance

Abstract In this work we study how features typically used in natural language processing tasks, together with measures from syntactic complexity, can be adapted to the problem of developing language profiles of bilingual children. Our experiments show that these features can provide high discriminative value for predicting language dominance from story retells in a Spanish–English bilingual population of children. Moreover, some of our proposed features are even more powerful than measures commonly used by clinical researchers and practitioners for analyzing spontaneous language samples of children. This study shows that the field of natural language processing has the potential to make significant contributions to communication disorders and related areas.
Prevalence and Characterization of Salmonella Isolates from Poultry Farms in Ilorin, Nigeria

Poultry birds are very important source of essential proteins in developing countries, but also play an important role in transmission of Salmonella to human and nonhuman. Exposure to this pathogen also occurs through use of poultry droppings as manure for crop and vegetable production. This study investigated prevalence of Salmonella in feces of poultry farms in Ilorin, Nigeria. Salmonella isolated were further characterized by molecular method. Fecal samples were cultured in pre-enrichment medium, Selenite F medium and finally sub-cultured on Salmonella-Shigella agar. None lactose fermenting colonies with black center were picked for presumptive identification using biochemical tests and confirmed by serological test by method previously described. Molecular characterization was carried out using 16S rRNA gene sequencing following standard procedure. Out of 170 samples collected and examined, 8 (4.7%) gave biochemical characteristics that resembled Salmonella, but only 6 (3.5%) were confirmed as Salmonella by polyvalent antisera. Molecular characterization revealed that serovars isolated were Salmonella Enteritidis 3 (1.8%) and Salmonella Paratyphi 3 (1.8%). Phylogenetic tree constructed by neighbor-joining method as derived from analysis of the 16S rRNA gene sequences showed close relationship to Salmonella Paratyphi strain FB0015 16S ribosoma RNA gene partial sequence to our Salmonella Paratyphi isolates. The detection of 3.5% prevalence rate of Salmonella serovar from feces of laying poultry birds my serve as potential source of transmission of this pathogen to human through chicken meat, egg or use of poultry dropping as manure in crop or vegetable production.
Status Inequality, Moral Disengagement and Violence

This paper studies the causal effect of status differences on moral disengagement and violence. To measure violent behavior, in the experiment, a subject can inflict a painful electric shock on another subject in return for money. We exogenously vary relative status in the realm of sexual attractiveness. In three between-subject conditions, the assigned other subject is either of higher, lower or equal status. The incidence of electric shocks is substantially higher among subjects matched with higher- and lower-status others, relative to subjects matched with equal-status others. This causal evidence on the role of status inequality on violence suggests an important societal cost of economic and social inequalities.