Miracle-dz/UniFAR-FTUs huggingface dataset:
The formation of a cross-selling initiative climate and its interplay with service climate

This study aims to explore the formation and consequences of a cross-selling initiative climate, as well as how a service climate, which provides an important boundary condition, affects both its formation and its ultimate impact on service-sales performance. This article identifies two important predictors of a cross-selling initiative climate: frontline employees’ perceptions of supervisors’ bottom-line mentality and their own sense of accountability. ,The multilevel data set includes 180 frontline staff and supervisors (team leaders) from 31 teams employed by a spa/beauty salon chain. Hierarchical linear modelling and partial least squares methods serve to analyse the data. ,Supervisors’ bottom-line mentality disrupts a cross-selling initiative climate. A sense of accountability exerts a positive impact at both individual and team levels. A service climate at the team level weakens the impact of a sense of accountability on a cross-selling initiative climate. A cross-selling initiative climate has a positive effect on team-level service-sales performance, but this effect is weakened by the service climate. ,This study conceptualises an important frontline work unit attribute as a climate. It offers an initial argument that a cross-selling initiative climate is a central factor driving a work unit’s service-sales performance, which can increase firms’ productivity and competitive advantages. With this initial attempt to explore the antecedents and consequences of a cross-selling initiative climate, the study also offers novel insights into the interplay between a service and a cross-selling initiative climate.
Androsterone Derivatives Substituted at Position 16: Chemical Synthesis, Inhibition of Type 3 17β-hydroxysteroid Dehydrogenase, Binding Affinity for Steroid Receptors and Proliferative/antiproliferative Activity on Shionogi (AR +) Cells

A series of androsterone (ADT) derivatives substituted at position 16 were efficiently synthesized in short reaction sequences; the ether analogues were also synthesized in the case of the methyl and allyl derivatives. The aim of this study was to develop inhibitors of the steroidogenic enzyme type 3 17 β -hydroxysteroid dehydrogenase and then evaluate their ability to inhibit this activity in transfected HEK-293 cells. For each compound we measured the percentage of inhibition of the transformation of 4-androstene-3,17-dione, the natural substrate of this steroidogenic enzyme, into the active androgen testosterone. The synthesized compounds proved to be weak inhibitors of this enzyme, but interestingly, these ADT derivatives do not bind to androgen, estrogen, glucocorticoid, and progestin receptors, suggesting no unsuitable receptor-mediated effects. One exception, 16 α -(3′-bromopropyl)-5 α -androstane-3 α,17 β -diol (8), the only compound bearing a hydroxy group at position 17 β instead of a ketone, showed a strong binding affinity for the androgen receptor (70% at 1 μM) and also exhibited an antiproliferative activity on Shionogi (AR +) cells (86% at 1 μM), which was comparable to that of hydroxyflutamide, a pure antiandrogen (100% at 1 μM).
Factors Involved in Fruit Calcium Deficiency Disorders

Understanding the mechanisms of calcium (Ca2þ) deficiency disorder development in plants has been a challenge for more than a 100 years. Previous studies support the hypothesis that Ca2þ deficiency disorders can be triggered by mechanisms that reduce plant Ca2þ uptake from the soil, fruit Ca2þ uptake from the plant, and Ca2þ translocation within the fruit, and also result in abnormal regulation of cellular Ca2þ partitioning. Plant Ca2þ uptake can be determined by Ca2þ content and availability in the soil, root growth, activity of apoplastic and symplastic pathways of root Ca2þ uptake, as well as uptake competition between Ca2þ and other nutrients. Fruit Ca2þ uptake is determined by Ca2þ content in the xylem sap, and xylem/phloem ratio of fruit sap uptake, which is affected by the rates of leaf and fruit transpiration and growth. Calcium translocation to distal fruit tissue, containing the lowest fruit Ca2þ content and the highest susceptibility to Ca2þ deficiency disorders, is potentially dependent on the cell wall Ca2þ-binding capacity and symplastic Ca2þ uptake by the tissue at the peduncle end of the fruit, abundance of functional xylem vessels connecting peduncle and distal fruit tissues, as well as the hydrostatic gradient required for Ca2þ translocation towards the distal tissue. Cellular Ca2þ partitioning is defined by the activity of Ca2þ channels, Ca2þ ATPases, and Ca2þ exchangers present in cellular membranes, as well as the capacity of the cell wall to bind Ca2þ, and the formation of Ca2þ precipitates in different cellular compartments. Therefore, 107 Horticultural Reviews, Volume 40, First Edition. Edited by Jules Janick. 2012 Wiley-Blackwell. Published 2012 by John Wiley & Sons, Inc. Ca2þ deficiency disorders in fruit may not be caused by a single factor, but most likely by a combination of mechanisms that lower Ca2þ concentration at a specific tissue and cell localization, leading to Ca2þ deficiency symptoms.
Offsite construction: strategic priorities for shaping the future research agenda

Modern Methods of Construction (MMC), Offsite Manufacturing (OSM), and Offsite Production (OSP) are all umbrella terms cited as being possible panacea solutions for addressing time, quality and cost concerns often associated with ‘traditional’ construction. In this respect, these issues have been on the agenda for a while now, with no viable business process models or solutions [cf. traditional to manufacturing/installation] being proffered or promoted as a meaningful ways forward. In an attempt to address this, a focus group workshop was established with domain experts to explore industry uptake and multidisciplinary expectations and priorities within the AEC sector. This paper presents findings from this session, covering the relationships between people, process and technology - mapped against the three core silos of Design, Manufacturing and Construction. Research areas investigated embraced several integral issues, from information and process flows, through to production, risk, and market drivers and inhibitors. Research findings identified a high demand for technology adoption in the design and construction remits, and a need to change traditional thinking across the whole supply chain. Core findings and priorities are presented for industry reflection in order to shape the future research agenda in this area.
Phase I and Pharmacokinetic Study of Pemetrexed plus Cisplatin in Chemonaive Patients with Locally Advanced or Metastatic Malignant Pleural Mesothelioma or Non–Small Cell Lung Cancer

Purpose: Pemetrexed is approved as monotherapy and in combination with cisplatin. The established combination dose was identified before the addition of folic acid and vitamin B12 to the treatment regimen. We evaluated the toxicity and pharmacokinetics (PK) of higher pemetrexed doses with cisplatin and vitamin supplementation. Experimental Design: Patients with malignant pleural mesothelioma or non–small cell lung cancer received pemetrexed doses from 500 to 900 mg/m2 + 75 mg/m2 cisplatin once every 21 days. Folic acid and vitamin B12 were administered per label recommendations. Results: Twenty-one patients received a combined total of 84 cycles. The maximum tolerated dose was 900 mg/m2 pemetrexed + 75 mg/m2 cisplatin. Dose-limiting toxicities at this dose included grade 3 anemia, bronchopneumonia, and neutropenia, and 1 death from sepsis secondary to grade 4 febrile neutropenia, considered possibly related to study drugs. The recommended dose was 800 mg/m2 pemetrexed + 75 mg/m2 cisplatin. Pemetrexed PK were consistent across doses; pemetrexed did not seem to affect total or free platinum PK. Conclusions: Pemetrexed with vitamin supplementation was safe and well tolerated at higher doses than the currently established 500 mg/m2 + 75 mg/m2 cisplatin. Based on this study, the recommended dose would be 800 mg/m2 pemetrexed + 75 mg/m2 cisplatin. However, recent studies showed a lack of improved efficacy for 900 or 1,000 mg/m2 single-agent pemetrexed versus 500 mg/m2 and a lack of PK/pharmacodynamic exposure-response relationship for the pemetrexed/cisplatin combination across pemetrexed exposures corresponding to this dose range. Based on currently available evidence, we recommend retaining the established dose.
Corporate responsibility in the fast fashion industry: how media pressure affected corporate disclosure following the collapse of Rana Plaza

The concept behind fast fashion is that of quickly-produced, low-priced, fashion items and, for many, it constitutes the opposite of sustainability. The collapse of Rana Plaza factory in 2013 generated greater focus on CSR issues within the fast fashion industry and raised important questions about whether the industry can be sustainable. This research aims to explore the reasons for which companies engage in CSR initiatives and whether global news media attention has an effect on companies' CSR disclosure and initiatives. The study draws upon legitimacy and media agenda setting theory to explore the link between CSR disclosure and news coverage. The research shows that CSR disclosures varied according to the companies' CSR profiles, and that media coverage differed according to companies' CSR initiatives and proactivity. This paper contributes to the literature by qualitatively exploring the relationship between media attention and corporate disclosure in the ready-made garment industry after a disaster.
Effects of increasing dietary L-carnitine on growth performance of weanling pigs.

Four experiments were conducted to evaluate the effects of supplementing graded levels (0 to 100 ppm) of L-carnitine to the diet of weanling pigs on growth performance during a 34- to 38-d experimental period. A fifth experiment was conducted to determine the effects of addition of L-carnitine to diets with or without added soybean oil (SBO) on growth performance. In Exp. 1, 128 pigs (initial BW = 5.5 kg) were allotted to four dietary treatments (six pens per treatment of four to six pigs per pen). Dietary treatments were a control diet containing no added L-carnitine and the control diet with 25, 50, or 100 ppm of added L-carnitine. In Exp. 2, 3, and 4, pigs (4.8 to 5.6 kg of BW) were allotted to five dietary treatments consisting of either a control diet containing no added L-carnitine or the control diet with 25, 50, 75, or 100 ppm of added L-carnitine. All diets in Exp. 1 to 4 contained added soybean oil (4 to 6%). There were seven pens per treatment (four to five pigs per pen) in Exp. 2, whereas Exp. 3 and 4 had five and six pens/treatment (eight pigs per pen), respectively. In general, dietary carnitine additions had only minor effects on growth performance during Phases 1 and 3; however, dietary L-carnitine increased (linear [Exp. 1], quadratic [Exp. 2 to 4], P < 0.03) ADG and gain:feed (G:F) during Phase 2. The improvements in growth performance during Phase 2 were of great enough magnitude that carnitine addition tended to increase ADG (linear, P < 0.10) and improve G:F (quadratic, P < 0.02) for the entire 38-d period. In Exp. 5, 216 weanling pigs (5.8 kg of BW) were allotted (12 pens/treatment of four to five pigs per pen) to four dietary treatments. The four dietary treatments were arranged in a 2 x 2 factorial with main effects of added SBO (0 or 5%) and added L-carnitine (0 or 50 ppm). Pigs fed SBO tended (P < 0.07) to grow more slowly and consumed less feed compared with those not fed SBO, but G:F was improved (P < 0.02). The addition of L-carnitine did not affect (P > 0.10) ADG or ADFI; however, it improved (P < 0.03) G:F. Also, the increase in G:F associated with L-carnitine tended to be more pronounced for pigs fed SBO than those not fed SBO (carnitine x SBO, P < 0.10). These results suggest that the addition of 50 to 100 ppm of added L-carnitine to the diet improved growth performance of weanling pigs. In addition, supplemental L-carnitine tended to be more effective when SBO was provided in the diet.
Collagen IV deposits do not prevent regrowing axons from penetrating the lesion site in spinal cord injury

Scarring is suggested to impede axon regrowth across the lesion site in the injured adult mammalian central nervous system. Collagen Type IV, as a major component of the scar formed after injury, is an impediment for successful axonal regeneration and a decrease in its amount is a prerequisite for regrowing axons to cross the lesion in the postcommissural fornix in the injured adult rat (Stichel et al. [1999] Neurosci. 93:321–333). The aim of the present study was to analyze the relationship between collagen IV deposits and regrowing axons at various times after dorsal hemi‐section of the adult rat spinal cord. Immunohistochemical double staining revealed that penetrating neurofilament‐positive axons and collagen IV deposits were co‐localized in the lesion site in the initial stages of axonal sprouting (between 7 and 14 days post‐operatively) and were still present 1 and 2 months post‐operatively. Interestingly, collagen IV‐immunoreactive areas located around cystic cavities formed at the site of injury 1 month post‐operatively, were devoid of axons. In conclusion, our observations indicate that collagen IV deposits after spinal cord injury do not prevent neurofilament‐positive regrowing axons from penetrating the lesion site. J. Neurosci. Res. 62:686–691, 2000. © 2000 Wiley‐Liss, Inc.
Evaluation of corticospinal tracts in ALS with diffusion tensor MRI and brainstem stimulation

Objective: To assess corticospinal tract involvement in patients with amyotrophic lateral sclerosis (ALS) by correlating diffusion tensor imaging (DTI) measures with intra- and extracranial central motor conduction time (CMCT) and clinical features of the patients. Methods: We investigated 31 patients with ALS and 31 normal volunteers by DTI and measured fractional anisotropy (FA) within the corticospinal tracts and in the extramotor white matter. We measured CMCT for the first dorsal interosseous muscle and segmented it into cortical-brainstem (CTX-BS CT) and brainstem-cervical root (BS-CV CT) conduction times by magnetic brainstem stimulation at the foramen magnum level. Clinical status of each patient was evaluated with the ALS Functional Rating Scale–Revised (ALSFRS-R) and upper motor neuron (UMN) score devised for this study. Results: We found a significant decrease of mean FA in all regions of the corticospinal tracts in patients with ALS as compared with controls. We found that FA along the corticospinal tract decreased significantly with higher UMN scores. There was no significant correlation between FA and ALSFRS-R, to which both upper and lower motoneuron involvements contribute. FA showed a significant correlation with the intracranial part of the central motor conduction (CTX-BS CT) but not with the extracranial conduction time. Conclusions: Fractional anisotropy reflects functional abnormality of intracranial corticospinal tracts and can be used for objective evaluation of upper motor neuron impairment in amyotrophic lateral sclerosis. GLOSSARY: ALS = amyotrophic lateral sclerosis; ALSFRS-R = ALS Functional Rating Scale–Revised; BS-CV CT = brainstem-cervical root conduction time; CMCT = central motor conduction time; CTX-BS CT = cortical-brainstem conduction time; FA = fractional anisotropy; FDI = first dorsal interosseous; LMN = lower motor neuron; ROI = region of interest; UMN = upper motor neuron.
The impact of attributions on academic performance: A test of the reformulated learned helplessness model

This series of two longitudinal studies represents a comprehensive and systematic attempt to investigate the tenets of the reformulated learned helplessness model in a non-clinical undergraduate student population. These studies specifically addressed the diathesis-stress and mediation components of the model in an attempt to replicate and extend the findings of Peterson and Barrett (1987). A total of 661 undergraduate students completed the AASQ, real event attributions scales, a grade aspiration scale and a grade satisfaction scale. Performance outcome measures and G.P.A. were obtained from official university records. Without exception, the present studies could not replicate the findings of Peterson and Barrett. Despite repeated attempts, no support for any component of the reformulated learned helplessness model was obtained when the theoretical tenets were applied to academic performance. In fact, significant positive correlations were observed between the generality dimension and the specific performance outcome measures. Consistent with the results reported by Houston (1994), it would appear high achieving students tend to make stable and global attributions for negative academic events. Alternately, it may be that academic performance differs in some way from performance outcome measures previously used to support the reformulated model and may, therefore, be unsuitable to test the predictions of the model. Notwithstanding these concerns, this study failed to replicate the results of Peterson and Barrett (1987) and found only minimal support for the reformulated learned helplessness model.
Intellectual Capital and the Performance of Manufacturing Companies in Indonesia

This study aimed at examining the effect of intellectual capital and its components covering value added capital employed, value added human capital, and structural capital value added on the firm performance. Intellectual capital was measured by using Pulic’s model, while the firm performance was measured by return on asset, return on equity, and market-to- book ratio. The samples used in this study were 103 manufacturing industries and we also investigated every subsector of the manufacturing industries including 51 basic and chemical industries, 30 miscellaneous industries, and 22 consumer goods industry listed on Indonesia Stock Exchange during the period of 2012 up to 2016. Multiple regression analysis was used to test the hypothesis. The result of the study showed that intellectual capital had a significant positive effect on return on asset, return on equity, and market-to-book intellectual capital on the firm performance in each subsector of the manufacturing industry. Value added capital employed as a component of intellectual capital was the most influential component on the firm performance. This findings indicated that a firm with great and well managed of capital employed, allowing a firm to improve their performance. Penelitian ini bertujuan untuk menguji pengaruh intellectual capital dan komponennya yang meliputi value added capital employed, value added human capital, dan structural capital value added terhadap kinerja perusahaan. Intellectual capital diukur menggunakan model Pulic, sementara kinerja perusahaan diukur dengan return on asset, return on equity, dan market-to-book ratio. Sampel yang digunakan dalam penelitian ini adalah 103 perusahaan pada industri manufaktur, dan kami juga kami meneliti masing-masing subsektor dari industri manufaktur yang meilputi 51 perusahaan pada industri dasar dan bahan kimia, 30 perusahaan pada aneka indstri, dan 22 perusahaan pada industri barang konsumsi yang terdaftar di Bursa Efek Indonesia selama jangka waktu 2012-2016. Analisis regresi berganda digunakan untuk menguji hipotesis. Hasil penelitian menunjukkan bahwa intellectual capital berpengaruh positif signifikan terhadap return on asset, return on equity, dan market-to-book ratio di semua industri. Selain itu, hasil penelitian ini juga menunjukkan bahwa tidak ada perbedaan pengaruh intellectual capital terhadap kinerja perusahaan pada masing-masing subsektor industri manufaktur. Value added capital employed yang merupakan komponen dari intellectual capital merupakan komponen yang paling berpengaruh terhadap kinerja perusahaan. Temuan ini menunjukkan bahwa perusahaan dengan modal yang besar dan dikelola dengan baik, memungkinkan perusahaan untuk meningkatkan kinerjanya.Intellectual capital, value added capital employed, value added human capital, structural capital value added, return on asset, return on equity, market-to-book ratio.
FGF-23 and the progression of coronary arterial calcification in patients new to dialysis.

BACKGROUND AND OBJECTIVE Fibroblast growth factor 23 (FGF-23), a regulator of phosphorus metabolism, is a risk marker in CKD. FGF-23 has been associated with coronary arterial calcification (CAC), but it is not known whether FGF-23 predicts CAC progression in CKD. The aim of this study was to evaluate the association of FGF-23 with CAC progression in advanced CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS FGF-23 levels and CAC were measured by electrocardiography-triggered multislice computed tomography in 99 individuals initiating dialysis. Patients were enrolled in the study from April 2008 to July 2010. CAC was calculated using Agatston and calcium volume score. Sixty-seven study participants had repeat CAC measures at 1 year. Linear regression was used to assess the association of FGF-23 with CAC. RESULTS The mean age of study participants was 50 years; 33% were women, and 64% were black. The median FGF-23 level was 1238 relative units (RU)/ml (interquartile range, 515-2218 RU/ml). According to Agatston score, FGF-23 was not associated with baseline CAC (P=0.14) but was significantly associated with CAC progression. There was a 192.3-Agatston unit change in CAC score per 1-SD change in FGF-23 (P=0.008) in models adjusting for known risk factors for CAC and serum phosphate. This association persisted after adjustment for high-sensitivity C-reactive protein, 25-OH vitamin D levels, and the use of phosphorus binders. Results were similar when change in calcium volume score was used. CONCLUSIONS In individuals with advanced CKD, serum FGF-23 is strongly associated with CAC progression. FGF-23 may be a marker of cardiovascular risk in CKD.
Effect of recombinant cytokines on leucocytes and physiological changes in bovine mammary glands during early involution

We examined the effects of administering recombinant bovine cytokines to non-lactating dairy cows and measured mammary gland leucocytes and the involution process. After the final milking, groups of cows were given an intramammary infusion of cytokine in two quarters. These cytokines were recombinant bovine interleukin-2 (rboIL-2) (2×105 units, n=6), recombinant bovine granulocyte-macrophage colony stimulating factor (rboGM-CSF) (500 μg, n=4) and recombinant bovine interleukin-1β (rboIL-1β) (10 μg, n=10). Each animal also received an infusion of phosphate-buffered saline (PBS) in the other two quarters as controls. The rboIL-2 and rboGM-CSF were produced in a yeast expression system, while rboIL-1β was produced in Escherichia coli. Leucocyte numbers, bactericidal activity of leucocytes, and concentrations of citrate and lactoferrin in quarter secretion samples were monitored after infusion of cytokine or PBS. Infusion of rboIL-2 had minimal effect on leucocyte numbers and concentrations of citrate and lactoferrin. Both rboGM-CSF and rboIL-1β induced a rapid increase in the number of neutrophils and macrophages compared with control PBS quarters. Concentrations of lactoferrin in secretions were increased by rboGM-CSF and rboIL-1β compared with control PBS quarters. In addition, infusion of glands with rboIL-1β lowered the citrate[ratio ]lactoferrin molar ratio compared with PBS control quarters. The results indicate that intramammary infusion of either rboGM-CSF or rboIL-1β at cessation of milking immediately increased the number of phagocytic cells in the gland. These cytokines, in particular rboIL-1β, also increased the rate of mammary gland involution during the early dry period.