Miracle-dz/UniFAR-FTUs huggingface dataset:
Initiation of delayed-type hypersensitivity by low doses of monoclonal IgE antibody. Mediation by serotonin and inhibition by histamine.

Elicitation of delayed-type hypersensitivity (DTH) responses by DTH effector T cells requires a prior phase of DTH initiation. This consists of an immediate hypersensitivity-like response mediated by Ag-specific DTH-initiating factors that are analogous to IgE antibodies in that they sensitize tissue mast cells for release of the vasoactive amine serotonin (5-HT). Experiments were conducted to determine whether IgE mAb injected i.v. , or 5-HT injected locally, could initiate DTH. It was found that small doses of IgE (1 microgram/mouse), or of 5-HT (50 to 500 ng locally), which mediated small immediate responses, were optimal for DTH initiation. Even lower doses of IgE (10 ng/mouse), or of 5-HT (5 ng locally), which did not mediate macroscopically measurable immediate responses, were capable of DTH initiation. Higher doses of IgE (10 to 100 micrograms/mouse), which mediated large immediate responses, were not able to initiate DTH. A similar dose response for DTH initiation was found with IgG1 mAb, which is another mast cell-sensitizing isotype of Ig. The inability of high doses of IgE or IgG1 to mediate DTH initiation was probably caused by local release of large inhibitory amounts of histamine, because systemic treatment with the histamine-2 receptor antagonist cimetidine allowed high doses of IgE to initiate DTH. Thus, IgE and IgG1 antibodies could initiate DTH via release of small amounts of 5-HT, but simultaneous release of large amounts of histamine were inhibitory, probably via an effect on histamine-2 receptors of recruited T cells. We concluded the following: 1) IgE or IgG1 antibodies can initiate DTH; 2) DTH initiation need not be associated with macroscopically detectable early responses; 3) mast cell release of 5-HT acts positively whereas release of histamine acts negatively in murine DTH; 4) Ag-specific factors are not the only mechanism of DTH initiation.
Microbial Flora of Normal and Abnormal Cervical Mucous Discharge Associated with Reproductive Performance of Cows and Heifers in Estrus

The aim of the present study was to describe whether abnormal cervical mucus discharge (A-CMD) or pathogens in cervical mucus discharge (CMD) have effects on reproductive performance of cows and heifers in estrus. Animals having clear discharges (68 cows, 38 heifers) with normal viscosity and without bad odor were grouped as normal cervical mucous discharge (N-CMD) group. The other animals (84 cows, 32 heifers) were grouped as A-CMD group. Microorganisms isolated from samples were divided into three groups as uterine pathogens (UP), potential uterine pathogens (PUP) or opportunistic uterine pathogens (OUP). Presence of PUP was associated with A-CMD for both cows (p<0.01) and heifers (p<0.02). First service conception rates (FS-CR) were lower in cows positive for PUP (p<0.01). Moreover, presence of PUP and OUP affected FS-CR in heifers (p<0.01). Although A-CMD significantly affected FS-CR in cows (p<0.04), it did not affect FS-CR in heifers. Differences in average open day for cows (p<0.02) and first service age for heifers (p<0.01) were significant between N-CMD and A-CMD groups, respectively. The current study suggested that CMD should be evaluated more carefully when there are infertility problems. In addition to the known microorganism that causes sterility and infertility in the UP group, pathogens in the PUP group should be considered for their potential to cause infertility. (Key Words : Discharge, Cow, Heifer, Fertility, Bacteria)
Plaque size, vessel size and plaque vulnerability: bigger may not be better.

Coronary thrombosis is now generally accepted as the proximate cause of acute coronary syndromes (1). Nearly 70% to 80% of coronary thrombi occur as a consequence of fissure or rupture of the fibrous cap of the plaque, with the remaining thrombi occurring from superficial endothelial erosions without a frank rupture or fissure (2–5). Plaques that have ruptured are generally characterized by a large, eccentric, lipid-rich atheromatous core, thinned-out fibrous caps with reduced smooth muscle cell and collagen content, increased inflammatory cell infiltration with mostly activated macrophages and, to a lesser extent, activated T-lymphocytes and mast cells, and increased neovascularization (6 – 8). Undisrupted plaques with similar compositional characteristics have, by inference, been considered vulnerable for disruption (the vulnerable plaque). While the histomorphometric features of ruptured plaques (and by inference vulnerable but unruptured plaques) are reasonably well accepted, the relationship of such features to the size of the plaque and the severity of luminal obstruction is not as clear. Angiographic studies have suggested that 60% to 70% of acute coronary syndromes evolve from coronary lesions that in the weeks to months prior to the acute event were only mildly or moderately obstructive of the lumen (1,4,9–11). Similarly, it has been shown that in 30% to 40% of cases of acute myocardial infarction, myocardial stress perfusion scintigraphy, performed weeks to months before the index infarction, failed to reveal evidence for reversible ischemia in the
Influence of distinct anatomic subregions of the supraspinatus on humeral rotation

The supraspinatus, having distinct anterior and posterior subregions, is most commonly considered an abductor of the humerus, but it has also been shown to induce humeral rotation. The objective of this study was to quantify the magnitude and direction of humeral rotation that results from loading the distinct anterior and posterior subregions of the supraspinatus. Fourteen cadaver specimens were tested under four loading conditions based on physiological cross section area of the supraspinatus: (1) anterior only; (2) posterior only; (3) physiologic (each subregion loaded simultaneously); and (4) nonphysiologic (the tendon loaded as a whole). Each specimen was tested at 0, 15, 30, 45, and 60° of glenohumeral abduction in the scapular plane and from 60° of internal to 45° of external rotation in 15° increments. The humeral rotation that occurred with loading from the initial starting rotation position was measured using a rotary variable inductance transducer. In the scapular plane, the anterior subregion of the supraspinatus acts as both an internal and external rotator depending on the initial position of the humerus. The posterior subregion either acted as an external rotator or did not induce rotation. This study demonstrated a distinct functional difference between the anatomic subregions of the supraspinatus. This understanding will help to improve testing methods and the development of repair strategies of the supraspinatus. © 2009 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 28:12–17, 2010
Axonal regeneration of an identified Helisoma neuron depends on the site of axotomy

Axotomy or molluscan neurons usually results in axonal regeneration. In this study, we tested the axotomy response of an identified neuron of the pond snail Helisoma trivolvis (buccal neuron 4, B4). This neuron has two primary axonal branches, the ipsilateral axon and the contralateral axon, each innervating one of the paired salivary glands. The ipsilateral axon projects via the ipsilateral esophageal nerve trunk whereas the contralateral axon crosses both buccal ganglia and projects via the contralateral esophageal nerve trunk. We tested various procedures of axotomy: injury to one axon or both axons, close to the ganglion or more distal. Surprisingly, we found that proximal axotomy of the ipsilateral axon was not usually followed by axonal regeneration. By contrast, all other procedures of axotomy (e.g., distal ipsilateral, or proximal bilateral) resulted in robust axonal regeneration and target reinnervation. Thus, in this preparation, axotomy may or may not result in axonal regeneration, depending on the site(s) of axotomy. To the best of our knowledge, such a differential result has not yet been found in any other preparation. We conclude that axotomy is not always a sufficient condition for axonal regeneration of molluscan neurons. We hypothesize that a damaged axonal stump may be a necessary condition for the initiation of regeneration. An alternative hypothesis is that neurite outgrowth is inhibited in normal mature neurons by a target‐derived factor. This hypothetical factor would be transported retrogradely, but not anterogradely, along axons.
Role of Persistence of Antigen and Indirect Recognition in the Maintenance of Tolerance to Renal Allografts

Background. We have previously shown that a 12-day treatment with cyclosporine A (CyA) facilitates induction of tolerance to class-I disparate kidneys, as demonstrated by acceptance of second, donor-matched kidneys without immunosuppression. In the present study, we have examined 1) the duration of tolerance in the absence of donor antigen and 2) the pathway of antigen recognition determining maintenance or loss of tolerance. Methods. Seventeen miniature swine received class-I mismatched kidneys with 12 days of CyA, and received second donor-matched kidneys without immunosuppression at 0, 1, 3, or 4 months after nephrectomy of the primary graft. Five were sensitized 6 weeks after nephrectomy of the primary graft, three with donor-matched skin grafts, and two with donor class-I peptides to eliminate direct pathway involvement. In addition, two long-term tolerant animals received class-Ic peptides. Results. Rejection of second grafts required at least a 3 month absence of donor antigen. Although donor-matched skin grafts in animals tolerant to kidneys induced antidonor cytotoxic T lymphocyte responses, second renal transplants revealed no evidence of sensitization. In contrast, immunization of recipients with donor class-I peptides after nephrectomy of the primary graft led to loss of tolerance at both T-cell and B-cell levels, as evidenced by rejection of the second graft in 5 days and development of antidonor immunoglobulin G. Peptide immunization of long-term tolerant in recipients bearing long-term renal grafts did not break tolerance. Conclusions. These data indicate that the renal allograft is required for the indefinite maintenance of tolerance, that indirect antigen presentation is capable of breaking tolerance, and that in tolerant animals, direct antigen presentation may suppress rejection, allowing tolerance to persist.
Application of a stress and coping model to positive and negative adjustment outcomes in colorectal cancer caregiving

This study examined relations between stress and coping predictors and negative (distress) and positive (positive affect, life satisfaction, positive states of mind, health) adjustment outcomes in colorectal cancer caregivers. A total of 622 caregivers and their care‐recipients completed questionnaires and interviews. Predictors included caregiving parameters, social support, appraisal (stress, control, challenge), and coping strategies (problem‐solving, avoidance, substance use, religion, humor, seeking social support). Regression analyses indicated that after controlling for the effects of relevant caregiving parameters (caregiver age, gender and paid employment status, care‐recipient quality of life, cancer stage), better caregiver adjustment was related to higher social support, lower stress and higher challenge appraisals, and less reliance on avoidance and substance use coping, as hypothesized. Stress appraisal emerged as the strongest and most consistent predictor of all adjustment outcomes. Findings support the utility of the stress and coping model of adjustment to caregiving in colorectal cancer. Copyright © 2009 John Wiley & Sons, Ltd.
Conditional Generative Adversarial Networks for Commonsense Machine Comprehension

Recently proposed Story Cloze Test [Mostafazadeh et al. , 2016] is a commonsense machine comprehension application to deal with natural language understanding problem. This dataset contains a lot of story tests which require commonsense inference ability. Unfortunately, the training data is almost unsupervised where each context document followed with only one positive sentence that can be inferred from the context. However, in the testing period, we must make inference from two candidate sentences. To tackle this problem, we employ the generative adversarial networks (GANs) to generate fake sentence. We proposed a C onditional GAN s (CGANs) in which the generator is conditioned by the context. Our experiments show the advantage of the CGANs in discriminating sentence and achieve state-of-the-art results in commonsense story reading comprehension task compared with previous feature engineering and deep learning methods.
Psychometric properties of the Postpartum Depression Predictors Inventory–Revised for pregnant women in Mexico

This study assessed the reliability and concurrent validity of the prenatal section of the Postpartum Depression Predictors Inventory–Revised for 250 pregnant women receiving prenatal care in Mexico. The Postpartum Depression Predictors Inventory–Revised has shown adequate psychometric properties for English-speaking perinatal women, but no similar data have been reported for Spanish-speaking samples. The results show that the Postpartum Depression Predictors Inventory–Revised is highly reliable and exhibits adequate concurrent validity compared to the Edinburgh Postnatal Depression Scale. These findings suggest that the Postpartum Depression Predictors Inventory–Revised can be a reliable instrument in prenatal care services for detecting risk factors for perinatal depression in Mexican women and potentially in other Spanish-speaking populations.
Understanding Mobile Social Media Usage: Uses and Gratification Expectancy Model

Despite the increasing popularity and growing trend of mobile social media in China, factors affecting users’ continued usage behavior remains unclear and deserves further scholarly attention. Synthesizing theories of expectation confirmation as well as uses and gratification, we advance a uses and gratification expectancy model that depicts how confirmation, perceived usability and gratification affect users’ continuance intention towards mobile social media. Empirical findings from an online survey of 247 respondents reveal that continuance intention is determined by a range of gratifications, including information sharing, media appeal and perceived enjoyment. In addition, confirmation of expectations and perceptions of usefulness gleaned through prior usage of mobile social media have significant effects on gratifications of information sharing, perceived enjoyment, social interaction, passing time and media appeal. Conversely, perceived ease of use exerts a weak impact on gratifications of media appeal and social interaction.
Understanding Behaviour: The Key to Successful Health Education

Effective health education requires an understanding of the factors which underlie a person's behavior. This paper describes "BASNEF," a simplified approach to understanding behavior, which is based on the PRECEDE model and on Value Expectancy Theory. Value Expectancy Theory holds that people will only perform a given behavior if they themselves see that it will provide benefits according to their perception of their situation and needs. Community beliefs and values may differ from those of health care workers. The perceived likelihood of different consequences of an act and the relative values of those outcomes determine the individual's attitude towards that act. The subjective norm consists of the net balance of the perceived attitudes of other people concerning the act. The person's attitude and the subjective norm must be balanced to arrive at the behavioral intention, the decision of whether or not to perform a behavior. Applying the BASNEF approach requires determining community perspectives regarding the behavior. The behavior must be defined as specifically as possible, and the materials and knowledge required for a motivated person to carry out the behavior must be considered. Some behaviors can be identified in which it is unrealistic to expect a change. The 1st priority must be toensure that all the enabling factors required for a motivated person to carry out the behavior, such as time, materials and education, are available. Social pressures must be addressed, particularly the opinions of influential persons. Changing the individual's beliefs and attitudes must come last. The proposed behavior may need to be modified to be acceptable. It is difficult to change beliefs which arise from direct experience, wider belief systems or which have been held for a long time. This BASNEF model can be used to design health education programs based on an understanding of the community.
Revisiting the Small-World Phenomenon

Research has explored how embeddedness in small-world networks influences individual and firm outcomes. We show that there remains significant heterogeneity among networks classified as small-world networks. We develop measures of the efficiency of a network, which allow us to refine predictions associated with small-world networks. A network is classified as a small-world network if it exhibits a distance between nodes that is comparable to the distance found in random networks of similar sizes—with ties randomly allocated among nodes—in addition to containing dense clusters. To assess how efficient a network is, there are two questions worth asking: (a) What is a compelling random network for baseline levels of distance and clustering? and (b) How proximal should an observed value be to the baseline to be deemed comparable? Our framework tests properties of networks, using simulation, to further classify small-world networks according to their efficiency. Our results suggest that small-world networks exhibit significant variation in efficiency. We explore implications for the field of management and organization.
Interexaminer reliability of eight evaluative dimensions of lumbar segmental abnormality: Part II.

OBJECTIVE The objectives of this study were to assess the interexaminer agreement of palpation for soft tissue and osseous pain along with visual observations in the lumbar spine. Second, the interexaminer agreement of dermothermograph and surface electromyographic (EMG) scans of the lumbar spine were assessed. Third, to perform these evaluations on symptomatic low back patients. Finally, the most reliable measurements were combined in a multidimensional index of segmental lumbar abnormality, which was assessed for interexaminer agreement. DESIGN This is an interexaminer reliability study of commonly used palpatory and instrumentation procedures used to assess lumbar segmental abnormality. SETTING This study was conducted at Pain Assessment and Rehabilitation Center (PARC) and the Center for Clinical Studies (CCS) at Northwestern College of Chiropractic. PATIENTS The patients involved in this study were symptomatic at the time of examination. The patients were recruited from the CCS clinic and PARC. RESULTS Palpation for osseous pain produced kappa coefficients ranging from . 48-. 90. Palpation for soft tissue pain produced kappa coefficients that ranged from . 40-. 79 and the kappas for visual observation ranged from . 34-. 84. The dermothermograph and surface EMG scanner were also assessed with the kappa coefficient for their reliability in assessing lumbar segmental abnormality. The kappa coefficients ranged from -. 13 to . 59 for the surface EMG and 0- . 63 for the dermothermograph measurements. Intraclass correlation coefficients for the surface EMG measurements ranged from . 20-. 55 and the dermothermograph measurements ranged from . 01-. 55. Palpation for pain (osseous and soft tissue) and visual observation were included in the multidimensional index of abnormality. The interexaminer agreement of detecting a manipulable lesion was evaluated by designating a lesion present with a positive two out of three tests. Kappa coefficients for the multidimensional index of lumbar abnormality ranged from a low of . 05 to a high of . 52. CONCLUSIONS Palpation for pain (osseous and soft tissue) and visual observation produced good to excellent interexaminer agreement and were included in the multidimensional index of abnormality. The interexaminer agreement of surface EMG scans and dermothermograph measurements were poor and considered to be clinically unacceptable, thus were not included in the multidimensional index. Palpation for pain is the only spinal assessment procedure to show consistent reliability in a number of studies.
Alcohol consumption patterns in a primary care population.

Over a one-year period the authors administered the Diagnostic Interview Schedule to 459 randomly selected patients attending an urban general medicine practice. Alcohol abuse and alcohol dependence disorders were diagnosed as current in 12% of the patients, while 19% of the patients met criteria for a past disorder. In addition, 11% and 3%, respectively, reported a history of previous or current heavy consumption. The lifetime prevalence of alcohol consumption disorders is significantly higher in males than females, while current disorders are significantly more common in younger than older individuals. Based upon the number of reported symptoms, patients reporting current disorders appear to have a more serious form of disease than patients reporting a past disorder. We conclude that disorders of alcohol consumption are common in our medical practice. Moreover, our findings suggest that many patients do recover from alcohol consumption disorders (i.e. are currently symptom-free by self-report) and disease severity may be an important factor in this process.
The legacy of the Alaska Siberia Medical Research Program: a historical perspective

Background. The Alaska Siberia Medical Research Program was established at the University of Alaska (UA) at a time when there was no research funded by the National Institutes of Health (NIH) that was concerned with Alaska Native health issues. The program grew out of a dire need for an understanding of the apparently rapidly growing health problems in the Native community. The initial plan included the following objectives. Objectives. The objectives are to develop a self-sustaining infrastructure for biomedical research by gaining support from Alaska Natives, UA, national political leaders, NIH and the Russian Academy of Medical Science (RAMS); to identify researchers committed to helping Alaska Natives; to develop meaningful, Native-driven participatory research; to carry out necessary research to form the foundation for future research; and to develop circumpolar collaborations. Results. The objectives were achieved because of the extraordinary and cheerful contributions by all participants in the program. The collaborative research resulted in some 70 published manuscripts identifying and characterizing research-neglected health problems. Unique risk factors for diabetes, cardiovascular disease, alcoholism and seasonal affective disorders were characterized and institutionalized prevention programs were established. The effort of the program led to U.S. Congressional action establishing the University of Alaska as a minority institution, leading to the funding of a variety of successful NIH-funded research centres and programs at the university that are concerned with Native health problems Conclusion. A small, visionary investment by the University of Alaska for establishing the program led to a co-operative effort by the UA, RAMS, Alaska Native Health communities and the NIH that resulted in the development of self-sustaining medical research efforts in Alaska and Siberia. The program spawned pilot studies, leading to NIH-funded research that has provided fundamental insights into the etiology of health problems and their reduction by research-based intervention and prevention programs.