Miracle-dz/UniFAR-FTUs huggingface dataset:
A Newly Described Ictal Pattern: The Initial Ictal Slow Shift

This report deals with a newly described ictal pattern, called the initial ictal slow shift (IS) 2 . This pattern may be seen in subdural records as the first sign of an ictal event, occurring before the later typical rhythms of a seizure state appear. A positive shift, very similar in appearance from one seizure to another, usually lasted for 1–2 sec, followed by a negativity for 7–9 sec that included the typical rhythmical discharges. At times, a negative shift occurred first, seen up to 15 mV very high in amplitude, for a few seconds before the typical ictal rhythms were seen. Scalp records may also demonstrate slow shifts, and examples are shown of the typical 3/sec bilateral spike and wave (S+W) complexes of absence seizures. A slow shift occasionally appeared 1 sec before the onset of these complexes, but more often a few seconds after the onset. Finally, after the end of the S+W complexes, a positive shift, for as long as 5–6 sec may occur, up to 600 μV in amplitude. These shifts could relate to data showing that patients are not really back to a normal responsiveness for at least 5 sec after the end of the S+W complexes (see Discussion).
Interobserver reliability of the Teller Acuity Card procedure in pediatric patients.

PURPOSE To compare interobserver agreement for Teller Acuity Card estimates of grating acuity between children with ocular or neurologic abnormalities, or both, and age-matched healthy preterm children. METHODS Subjects were 57 children, 3 to 38 months of age, who were referred for visual assessment because of diagnosed or suspected visual impairment (clinical group), and 57 healthy preterm children with no known visual or neurologic abnormalities (control group), each of whom was matched to a clinical subject, based on corrected age at the time of testing, and type of testing (monocular or binocular). Each child's grating acuity was tested by two independent observers. RESULTS Interobserver agreement of 1 octave or better was found in 91% of the monocular and 96% of the binocular clinical test-retest comparisons and in 95% of the monocular and 96% of the binocular control comparisons. For estimates of interocular acuity difference, interobserver agreement of 1 octave or better was found in 88% of clinical subjects and 88% of control subjects. Average test time was significantly longer in the clinical group (4.1 minutes [SD = 1.9] for monocular and 3.6 minutes [SD = 1.9] for binocular tests) than in the control group (2.5 minutes [SD = 0.9] for monocular and 2.4 minutes [SD = 0.6] for binocular tests), suggesting that children in the clinical group were more difficult to test. CONCLUSIONS Teller Acuity Card testing conducted by experienced testers is as reliable in children with mild to severe ocular or neurologic abnormalities as it is in healthy children, even though children with abnormalities may be more difficult to test.
Comparative Proteome Analysis Reveals Four Novel Polyhydroxybutyrate ( PHB ) Granule-Associated Proteins in Ralstonia eutropha H 16

Identification of proteins that were present in a polyhydroxybutyrate (PHB) granule fraction isolated from Ralstonia eutropha but absent in the soluble, membrane, and membrane-associated fractions revealed the presence of only 12 polypeptides with PHB-specific locations plus 4 previously known PHB-associated proteins with multiple locations. None of the previously postulated PHB depolymerase isoenzymes (PhaZa2 to PhaZa5, PhaZd1, and PhaZd2) and none of the two known 3-hydroxybutyrate oligomer hydrolases (PhaZb and PhaZc) were significantly present in isolated PHB granules. Four polypeptides were found that had not yet been identified in PHB granules. Three of the novel proteins are putative / -hydrolases, and two of those (A0671 and B1632) have a PHB synthase/depolymerase signature. The third novel protein (A0225) is a patatin-like phospholipase, a type of enzyme that has not been described for PHB granules of any PHB-accumulating species. No function has been ascribed to the fourth protein (A2001), but its encoding gene forms an operon with phaB2 (acetoacetyl-coenzyme A [CoA] reductase) and phaC2 (PHB synthase), and this is in line with a putative function in PHB metabolism. The localization of the four new proteins at the PHB granule surface was confirmed in vivo by fluorescence microscopy of constructed fusion proteins with enhanced yellow fluorescent protein (eYFP). Deletion of A0671 and B1632 had a minor but detectable effect on the PHB mobilization ability in the stationary growth phase of nutrient broth (NB)-gluconate cells, confirming the functional involvement of both proteins in PHB metabolism.
Design of a Biotechnology Laboratory in Mexico: Key Issues

Public research and development labs in Mexico are few and they have been created only in the last four decades. Little experience is available regarding successful organizational models, as well as best structure and processes in their design. Currently, the need for a research center on genomics and biodiversity has become increasingly important, and its design and creation is in process. The design of this center, however, is built on an analysis of similar research institutions abroad, as well as on the basis of what the specialized literature regards as best practices on several scores. For example, its structure and workflows, as well as its knowledge management practices and infrastructure will have to be carefully considered. Its impending creation will be of the utmost importance for the country, but it will also become a strategic competitor for international business in the field. This paper discusses the key issues in the design and creation of this organization, and in the development of its research capabilities
Banking on brains: Insights of brain donor relatives and friends from an experiential perspective

Brain donation is critical to understand the pathological causes of neurodegenerative diseases. Increasing levels of donation requires an understanding of those factors that both encourage and deter donation. At present, there are few studies of how people understand, feel and decide about brain donation for scientific research. This qualitative experiential study contributes to the growing literature on brain donation through its specific focus on how the donation process is experienced from the perspectives of family members and friends. Nineteen semi-structured interviews were analysed using a phenomenologically informed thematic analysis. Four themes were derived from the analysis, three of which are described in detail: Making the decision to donate; a personal perspective on the donation process; the significance of the brain; beliefs about brain donation. In particular, the thematic analysis highlights the variation of individual decision making and the emotions and reasons underpinning such decisions. Key conclusions include the importance of integrated practice amongst relevant healthcare professionals as well as the need for supportive and informed communication. Also, in light of the finding that the brain assumed no special significance for most participants, the value of the distinction between brain donation for research purposes and organ transplantation is questioned.
Eg5 inhibitor YL001 induces mitotic arrest and inhibits tumor proliferation

Eg5 is a kinesin spindle protein that controls chromosomal segregation in mitosis and is thus a critical drug target for cancer therapy. We report the discovery of a potent, selective inhibitor of Eg5 designated YL001. YL001 was obtained through shape similarity based virtual screening, and it bears a 1,5-disubstituted tetrazole scaffold. YL001 exhibits favorable bioactivity in a variety of cancer cell lines, including taxol-resistant ovarian cancer and 6TG-resistant breast cancer cell lines. This compound inhibits tumor growth by 60% and significantly prolongs median survival time by more than 50% in a xenograft mouse model. YL001 blocks the ATPase activity of Eg5 and causes mitotic failure, ultimately resulting in apoptosis of cancer cells through activation of the caspase-3 pathway. Our findings demonstrate that YL001 is a potent antitumor agent that may be developed for cancer therapeutics.
BEREZIN–TOEPLITZ QUANTIZATION OF THE MODULI SPACE OF FLAT SU(N) CONNECTIONS

Communicated by Theodore Voronov Abstract. The moduli space of flat SU(n) connections on Riemann surfaces is of fundamental importance in TQFT. There is an associated representation of the mapping class group on the space of covariantly constant sections of the Verlinde bundle with respect to the AdPW-H connection. J. Andersen showed that this representation is asymptotically faithful. In his proof the Berezin-Toeplitz quantization of compact Kähler manifolds is used. In this contribution the background and some ideas of Andersen’s proof is sketched.
The Validity and Utility of the Positive Presentation Management and Negative Presentation Management Scales for the Revised NEO Personality Inventory

Schinka, Kinder, and Kremer developed “validity” scales for the Revised NEO Personality Inventory (NEO PI-R; Costa & McCrae) to detect underreporting—the Positive Presentation Management (PPM) Scale and overreporting—the Negative Presentation Management (NPM) Scale. In this investigation, the clinical utility of these scales was examined using the established validity scales from the Minnesota Multiphasic Personality Inventory–2 (MMPI-2; Butcher et al.) as the referent. The sample was composed of 370 psychiatric patients who completed the NEO PI-R and the MMPI-2 as part of a routine evaluation. Results indicated that response distortion compromised the utility of the NEO PI-R domain scales. Moreover, the PPM and NPM scales and an NPM–PPM index significantly differentiated invalid under-and overreporting groups from a valid responding group. The PPM and NPM–PPM index were adequate in classifying under- and overreporters, respectively.
Variations in the circle of willis in Macaca mulatta

The circle of Willis was dissected in 75 Macaca mulatta monkeys, and the anatomy is described and compared with several series of human specimens. The principal difference between monkey and man is the presence of a single distal anterior cerebral artery in the former, and the most common anomaly in the moneky is an anterior communicating artery proximal to the junction of the anterior cerebral arteries.
Temperature regulation during continuous and intermittent exercise in man.

Ekblom, B. C. J. Greenleaf, J. E. Greenleaf and L. Hermansen, Temperature regulation during continuous and intermittent exercise in man. Acta physiol. scand. 1971. 81. 1–10. Body temperature changes and heat dissipation responses were studied in three well-trained men during moderately heavy (60 % of maximal aerobic power) continuous and intermittent exercise at the same average metabolic rate and heat production. The purpose was to determine if hypothetical “work factors” induced specifically by muscular activity influenced body temperature regulation. Compared with continuous work; a) the equilibrium level of rectal temperature (Tre) during intermittent work was elevated 0.35° C which accounted for 21 % of the total Tre increase from resting, and b) the decreased sweating of 32 g/(m2. hr) during intermittent work resulted in a decreased evaporative heat loss of 18.6 kcal/(m2. hr) that could account for the increased intermittent work Tre. These responses appear to be manifestations of reduced thermoregulatory efficiency due, perhaps, to non-linearity in the relationship of body temperature to total work rate or to non-linearity in the contribution of non-thermal inputs at work rates above 100 % of max. VO2. It is also possible that other factors play a part, such as the frequency and duration of the work and rest cycles, rate of limb movement, or circulatory factors related to postural changes.
Further aspects of fur trade life depicted in the skeleton

Osteobiographies were reconstructed from the skeletal remains of four adults from Fort Edmonton, a 19th century trading post of the Canadian fur trade. Three males were Caucasoid and probably ethnic Scots, given the usual origin of fur traders in this region. The lone adult female in the sample was Mongoloid, either Indian or Metis, and likely the ‘country wife’ of a fur trader, since she was buried in the European tradition in the fort cemetery. The cause of death is not discernible from any of the skeletal remains and none of these individuals exhibit any evidence of chronic infectious disease, malnutrition or neoplasia. Trauma, arthritis and other indicators of physical stress do appear, however, and present an opportunity to expand our understanding of the effects of fur trade life on the skeleton. Viewed in the context of historical accounts of life at the fort in the early 19th century, stress markers on the skeletons of three males have led to the conclusion that they were voyageurs who engaged in trading trips by canoe or boat. Lesions of the capsule attachment area at the proximal tibio-fibular articulation appear unilaterally in two males and may be associated with ‘mushing’ or driving a dog sled in winter. The musculoskeletal lesions on the one preserved female skeleton are consistent with the arduous domestic activities documented at the fort, which include milking cows, churning butter, stirring lye soap, and harvesting grain and root vegetables by hand. Since specific occupations or behaviours cannot be precisely determined from muscular attachment and other stress markers, these interpretations are made cautiously and only in the culture-historical context of the skeletal sample. Copyright © 1999 John Wiley & Sons, Ltd.
Factors associated with treatment initiation for psychiatric and substance use disorders among persons with HIV.

OBJECTIVE Prior studies of individuals with HIV infection have found that accessing psychiatric and substance abuse treatment when needed can improve health and prolong life, yet little is known about factors associated with treatment initiation. METHODS In a retrospective cohort design including individuals with HIV infection (≥14 years old) in an integrated health care system in Northern California, this study included 822 patients with a major psychiatric diagnosis and 1,624 with a substance use disorder diagnosis. Data were extracted from a regional HIV registry and computerized databases. RESULTS Twenty-four percent (N=198) of study patients with psychiatric diagnoses and 15% (N=245) with substance abuse or dependence received one or more specialty care visits within 12 months of diagnosis. Among patients with a psychiatric diagnosis, significant predictors of visiting a psychiatry clinic included not having an AIDS diagnosis at baseline or before the study (p=.049), having a diagnosis of major depression (p=.013), having a diagnosis of bipolar disorder (p<.001), and receiving a psychiatric diagnosis in 1996 versus later years of the study (p<.01). Among patients with a substance use disorder, significant predictors of initiating substance abuse treatment included age <30 (p=.015) and being in the HIV transmission risk group of injection drug use (p<.001). CONCLUSIONS Clinical, diagnostic, and demographic factors were associated with specialty care treatment initiation in this sample of individuals with HIV infection and substance use or psychiatric disorders. Developing strategies to enhance treatment initiation has the potential to improve outcomes for individuals with HIV infection.
An Empirical Study of Factors Affecting RFID's Adoption in Taiwan

RFID technologies represent a common standard for data storage and retrieval that could improve collaboration and data sharing between non-competing organizations. With the advent of RFID (radio frequency identification), organizations have the opportunity to rethink how their organization will be. Unlike companies in the United States and Europe which are mandated by large retailers or government departments, most Taiwan companies are investing in RFID without pressure. The article explores the factor affecting radio frequency identification adoption applications in Taiwan. Its objective is to summarize the ways in which organizations are thinking about their possible uses in a wide variety of companies and industries. An empirical investigation (n=134) found seven factors affecting RFID adoption within Taiwan. They are operation efficiency, manufacturing efficiency and supply chain efficiency, organization context, investment cost, market environment, and technology characteristic. By providing insight into these important factors, this article can help further understanding of their role in the adoption and use of RFID. The theoretical and practical implications of these results are discussed.
Inconsistent models for relevant arithmetics

This paper develops in certain directions the work of Meyer in [3], [4], [5] and [6] (see also Routley [10] and Asenjo [11]). In those works, Peano's axioms for arithmetic were formulated with a logical base of the relevant logic R, and it was proved finitistically that the resulting arithmetic, called R#, was absolutely consistent. It was pointed out that such a result escapes incautious formulations of Gödel's second incompleteness theorem, and provides a basis for a revived Hilbert programme. The absolute consistency result used as a model arithmetic modulo two. Modulo arithmetics are not ordinarily thought of as an extension of Peano arithmetic, since some of the propositions of the latter, such as that zero is the successor of no number, fail in the former. Consequently a logical base which, unlike classical logic, tolerates contradictory theories was used for the model. The logical base for the model was the three-valued logic RM3 (see e.g. [1] or [8]), which has the advantage that while it is an extension of R, it is finite valued and so easier to handle. The resulting model-theoretic structure (called in this paper RM32) is interesting in its own right in that the set of sentences true therein constitutes a negation inconsistent but absolutely consistent arithmetic which is an extension of R#. In fact, in the light of the result of [6], it is an extension of Peano arithmetic with a base of a classical logic, P#. A generalisation of the structure is to modulo arithmetics with the same logical base RM3, but with varying moduli (called RM3i here).
Effects of a Retention Intervention Program for Associate Degree Nursing Students

AIM To evaluate the effects of a retention intervention program on nursing students' persistence in obtaining an associate's degree. BACKGROUND An associate degree nursing program at a large community college used a three‐year grant from the US Department of Labor to create a program to improve retention of nursing students. METHOD Seven retention interventions (stipends, learning communities, comprehensive orientation, individualized academic planning, counseling, peer tutoring, and community nurse mentoring) were provided to participants. Correlational analyses were conducted between demographic variables and degree completion and between individual intervention program participation and degree completion. RESULTS The program produced a statistically significant improvement in retention, but no specific intervention or mixture of interventions was significantly correlated with retention. CONCLUSION Retention programs must be comprehensive, integrated efforts in order to increase the degree completion rate.
Construction and evaluation of PHP‐based management and training system for electrical power laboratory

The online management and training of information for laboratories has rarely been discussed in the traditional education system design. However, it plays a vital role in informatization and automation of electrical power laboratory. Using PHP: Hypertext Preprocessor (PHP), we have designed and developed an online management and training environment targeted for electrical power laboratory. In this article, the Model‐View‐Controller (MVC) architecture cooperative designed for the management and training system modules was provided, and key steps of developing such modules using PHP were described. A questionnaire survey was conducted for students to use the system, and their attitudes toward the system were calculated and analyzed. Results showed that management and training system for electrical power laboratory can lead to preferable learning interest and outcome. © 2016 Wiley Periodicals, Inc. Comput Appl Eng Educ 24:371–381, 2016; View this article online at wileyonlinelibrary.com/journal/cae; DOI 10.1002/cae.21715
Molecular cloning, structural analysis, and expression of carp ZP3 gene

Two types of cDNAs coding for a major component of carp egg membrane were clones from a carp ovarian cDNA library. They encode polypeptides of 422–424 amino acid residues whose sequences are homologous to those of medaka and mammalian ZP3. Similar to the mammalian ZP3 genes, carp ZP3 gene also consists of eight exons and seven introns. Carp ZP3 genes are 2.9 kb in length and present in multiple forms. Carp ZP3 is a glycoprotein of 45 kDa. It was transcribed and translated exclusively in oocytes, in contrast with medaka ZP3, which was synthesized in liver. The transcription of carp ZP3 starts very early in oogenesis, but translation occurs during vitellogenesis, as it is present in vitellogenic but not in previtellogenic oocytes. ZP3 content in oocytes increases as vitellogenesis proceeds. © 1996 Wiley‐Liss, Inc.
SSeCKS, a Major Protein Kinase C Substrate with Tumor Suppressor Activity, Regulates G1→S Progression by Controlling the Expression and Cellular Compartmentalization of Cyclin D

ABSTRACT SSeCKS, first isolated as a G1→S inhibitor that is downregulated in src- and ras-transformed cells, is a major cytoskeleton-associated PKC substrate with tumor suppressor and kinase-scaffolding activities. Previous attempts at constitutive expression resulted in cell variants with truncated ectopic SSeCKS products. Here, we show that tetracycline-regulated SSeCKS expression in NIH 3T3 cells induces G1 arrest marked by extracellular signal-regulated kinase 2-dependent decreases in cyclin D1 expression and pRb phosphorylation. Unexpectedly, the forced reexpression of cyclin D1 failed to rescue SSeCKS-induced G1 arrest. Confocal microscopy analysis revealed cytoplasmic colocalization of cyclin D1 with SSeCKS. Because the SSeCKS gene encodes two potential cyclin-binding motifs (CY) flanking major in vivo protein kinase C (PKC) phosphorylation sites (Ser507/515), we addressed whether SSeCKS encodes a phosphorylation-dependent cyclin scaffolding function. Bacterially expressed SSeCKS-CY bound cyclins D1 and E, whereas K→S mutations within either CY motif ablated binding. Activation of PKC in vivo caused a rapid translocation of cyclin D1 to the nucleus. Cell permeable, penetratin-linked peptides encoding wild-type SSeCKS-CY, but not K→S or phospho-Ser507/515 variants, released cyclin D1 from its cytoplasmic sequestration and induced higher saturation density in cyclin D1-overexpressor cells or rat embryo fibroblasts. Our data suggest that SSeCKS controls G1→S progression by regulating the expression and localization of cyclin D1. These data suggest that downregulation of SSeCKS in tumor cells removes gating checkpoints for saturation density, an effect that may promote contact independence.