Miracle-dz/UniFAR-FTUs huggingface dataset:
Self-reported physical activity improves prediction of body fatness in young adults.

PURPOSE To examine self-reported physical activity levels from the International Physical Activity Questionnaire (IPAQ) as an independent predictor of dual-energy x-ray absorptiometry (DXA)-measured percent body fat (%BF) from body mass index (BMI), gender, and race. METHODS Two hundred and seventy-eight students, aged 18-24 yr, volunteered to participate. There were 133 males (85 white and 48 black) and 145 females (77 white and 68 black). Total activity levels were quantified in MET hours per week (MET h wk(-1)) using the IPAQ short form. Height and weight were measured, and BMI values were calculated (kg m(-2)). %BF was assessed using DXA. Linear regression analysis was used to develop and compare a body fat prediction equation with (full) and without (reduced) the variable MET-h.wk. Both models included BMI, gender, and race as predictor variables. The prediction sum of squares (PRESS) statistic was used to cross-validate both models, and the individual predictive accuracy was compared using modified Bland-Altman plots. RESULTS Mean +/- SD values were as follows: BMI = 24.4 +/- 4.1 kg m(-2), %BF = 24.5 +/- 9.3%, and MET h wk(-1) = 37.4 +/- 21.9. Gender, BMI, and race explained 81% of the variance in %BF, with a root mean square error (RMSE) of 4.07. The full model with MET-h.wk improved the prediction of %BF by 2% (R2 = 0.83, RMSE = 3.87). When cross-validated, the corresponding PRESS statistics for the reduced and full model were 4.10 and 3.90, respectively. Bland-Altman limits of agreement were greater for the reduced model compared with the full model (-8.09, 8.10 vs -7.67, 7.68). CONCLUSION These results suggest that %BF can be predicted with greater precision and accuracy in a young adult population when MET-h.wk are included in addition to BMI, gender, and race.
Consultant-liaison psychiatrists and euthanasia in The Netherlands

On 30 November 1993 a nine year political de bate on euthanasia closed; the first chamber of the Dutch parliament ratified the law on under taking, including euthanasia regulations. This political step concluded, for the time being at least, a legal, public, political and medical de bate, which started in 1973, when a medical doctor was convicted for performing euthanasia on her mother. In a first effort in 1983, parlia ment failed to legalise euthanasia. In 1989 a new government introduced an initiative to improve the existing law in this regard. As a part of the process, empirical data on the extent of euthanasia in The Netherlands were required. Therefore, the Minister of Justice installed a committee. Its findings have been reported nationally and internationally (van der Maas et al, 1991a, 1991b); about 2,300 euthanasia cases in 1990, being 1.8% of all deaths. These empirical findings reduced the uncertainties about the extent of euthanasia, thereby pro viding a sound basis for the parliamentary decision-making process. Although by the cur rent law euthanasia and assisted suicide still remain illegal, under strict guidelines for behav iour provided by the Ministry of Justice In November 1990 and distributed among phys icians in January 1991, euthanasia can be exempted by the public prosecutor from criminal punishment on the basis of the 'opportunity'
Comparison of collaborative filtering algorithms

The technique of collaborative filtering is especially successful in generating personalized recommendations. More than a decade of research has resulted in numerous algorithms, although no comparison of the different strategies has been made. In fact, a universally accepted way of evaluating a collaborative filtering algorithm does not exist yet. In this work, we compare different techniques found in the literature, and we study the characteristics of each one, highlighting their principal strengths and weaknesses. Several experiments have been performed, using the most popular metrics and algorithms. Moreover, two new metrics designed to measure the precision on good items have been proposed. The results have revealed the weaknesses of many algorithms in extracting information from user profiles especially under sparsity conditions. We have also confirmed the good results of SVD-based techniques already reported by other authors. As an alternative, we present a new approach based on the interpretation of the tendencies or differences between users and items. Despite its extraordinary simplicity, in our experiments, it obtained noticeably better results than more complex algorithms. In fact, in the cases analyzed, its results are at least equivalent to those of the best approaches studied. Under sparsity conditions, there is more than a 20% improvement in accuracy over the traditional user-based algorithms, while maintaining over 90% coverage. Moreover, it is much more efficient computationally than any other algorithm, making it especially adequate for large amounts of data.
Lower prevalence of hypertension, hypercholesterolemia, and diabetes in marathoners.

PURPOSE To test whether the prevalence of hypertension, hypercholesterolemia, and diabetes declines with marathon participation independent of annual running mileage. METHODS Cross-sectional associations of self-reported medication use in 62,284 male and 45,040 female participants of the National Runners' Health Study adjusted for age, diet, alcohol, and annual distance run. RESULTS By self-report, 31.7% of men and 29.1% of women ran 0.2 and 0.8 marathons per year, 8.6% of men and 4.4% of women ran between 1.0 and 1.8 marathons per year, and 3.8% of men and 1.5% of women ran an average of >or=2 marathons per year. The men's odds ratio per marathons per year run was 0.85 for antihypertensive (P < 0.0001), 0.87 for LDL-cholesterol-lowering (P = 0.002), and 0.52 for antidiabetic medication use (P < 0.0001). Compared with nonmarathoners, men who averaged 0.2-0.8 marathons per year had 13% lower odds for antihypertensive medication use, 22% lower odds for LDL-cholesterol-lowering medication use, and 67% lower odds for antidiabetic medication use. Marathon participation was also associated with lower LDL-cholesterol-lowering and antidiabetic medication use in women, but not when adjusted for annual distance run. Each additional hour required to complete their marathon had odds ratio of 1.31 and 1.22 for men's antihypertensive and LDL-cholesterol-lowering medication use and 2.01 for women's antidiabetic medication use (all P < 0.0001). Among all runners (marathoners and nonmarathoners combined), prevalence in the use of all three medications decreased in association with the length of the longest usual run, independent of total annual mileage. CONCLUSION Prevalence of hypertension, hypercholesterolemia, and diabetes decreases with the frequency of marathon participation independent of annual running distance. This may be due to the inclusion of longer training runs in preparation for marathons or to genetic or other innate differences between marathon and nonmarathon runners.
Effects of amino acids supplement on physiological adaptations to resistance training.

INTRODUCTION Previous research has demonstrated that ingestion of essential amino acids and their metabolites induce anabolic effects with the potential to augment gains in lean body mass and strength after resistance exercise training. PURPOSE The purpose of the present study was to examine the effects of an essential amino acid-based formula (Muscle Armor (MA); Abbott Laboratories, Abbott Park, IL) containing beta-hydroxy-beta-methylbutyrate (HMB) on hormonal and muscle damage markers in response to 12 wk of resistance exercise. METHODS Seventeen healthy men (mean body mass: 77.9 +/- 7.2 kg; mean height: 174.3 +/- 12.4 cm; mean age: 22.9 +/- 3.8 yr) were matched and randomized into two groups and performed 12 wk of periodized heavy resistance training while supplementing with either MA or an isocaloric, isonitrogenous placebo (CON). Every 2 wk during the 12-wk intervention, resting blood draws were obtained, and muscle strength and power were measured. In addition, blood draws were obtained before, during, and after a standardized resistance exercise challenge performed pre-, mid-, and posttraining. RESULTS Lean body mass, muscle strength, and muscle power significantly (P <or= 0.05) increased in both groups after training; however, MA supplementation augmented these responses to a significantly greater extent when compared with the CON group. MA supplementation promoted increases in resting and exercise-induced testosterone and resting growth hormone concentrations. In addition, MA reduced preexercise cortisol concentrations. Throughout the training protocol, MA attenuated circulating creatine kinase and malondealdehyde compared with the CON group, suggesting that MA might have influenced a reduction in muscle damage. CONCLUSION MA supplementation beneficially affected training-induced changes in lean body mass, muscle strength, and power, as well as hormonal responses and markers of muscle damage in response to 12 wk of resistance exercise training when compared with an isonitrogenous control.
World-Wide

During the last three months (January to March 2011), 826 H5N1 HPAI outbreaks in poultry were reported from the following countries: Bangladesh, Cambodia, Egypt, China (Hong Kong SAR), India, Indonesia, Israel, Japan, Myanmar, Republic of Korea, Viet Nam and The West Bank and Gaza Strip. Fifty wild bird cases were reported during the same period in Bangladesh, China (Hong Kong SAR), Japan and the Republic of Korea. The number of reported outbreaks/cases by country and their location are illustrated in Table 1 and Figure 1. Table 1 H5N1 HPAI outbreaks/cases in poultry and H5 and H5N1 infection in wild birds in January, February and March 2011 (Source: FAO EMPRES-i, OIE WAHIS)
Prevalence of Salmonella enterica, Escherichia coli and Staphylococcus aureus in Raw Meat in Thai Self-Service Style Restaurants in Khon Kaen Municipality

One hundred and fifty eight raw meat samples were collected from 33 Thai self-service style restaurants in Khon Kaen municipality during July-October 2011. The fresh meat included pork, beef and chicken and was provided for self-grilling or boiling. All the samples were examined for contamination of three major foodborne pathogens including Salmonella enterica , Escherichia coli and Staphylococcus aureus using standard protocol. High prevalence of S. enterica (44%), E. coli (60%) and S. aureus (25%) was observed. Seventy-seven percent of the samples were positive for at least one of the three pathogens, while only 8% were found to carry all three pathogens. The prevalence of Salmonella, S. aureus and E. coli was observed in different rates in pork (59%, 69% and 33%, respectively), beef (52%, 56% and 28%, respectively) and chicken (18%, 56% and 12%, respectively). When consider meat type, the highest contamination frequency was found in pork (87%), followed by beef (78%) and chicken (64%). The results indicate the requirement of quality and hygiene control policy for raw meat served in self-service restaurants and that public awareness of food poisoning caused by consumption of undercooked meat should be raised.
An Epidemiological study of Organophosphorus Poisoning at Manipal Teaching Hospital, Pokhara, Nepal

Organophosphorus compounds are chemical compounds containing carbon-phosphorus bonds (apart from phosphate and phosphite esters), primarily used in pest control and are often persistent organic pollutants. Acute poisoning by organophosphorus (OP) compounds is a major global clinical problem, with thousands of deaths occurring every year in Nepal. Most of these pesticide poisoning and subsequent deaths occur due to deliberate self ingestion of the poison. Sixty five patients with severe organophosphorus poisoning were admitted to the emergency ward of Manipal Teaching Hospital, Pokhara, Nepal from January 2008 to December 2008. History of ingestion, clinical signs & symptoms and survival time in case of death was also recorded to diagnose the OP poisoning. The mean age of patients was about 27 years. Most of the admitted cases were of suicidal in nature and women are the main victim. Suicidal deaths due to ingestion of organophosphorus compound are very common in Nepal especially in women. The reason may be the increasing stress in the family and economic constraints. Further study should be needed by government and NGO to evaluate it. Key Words: Organophosphorus, Poisoning, Nepal, Carbon-Phosphorus, Suicide
Co-Occurrence of Substance use Disorders with other Psychiatric Disorders: Implications for Treatment Services

Introduction This paper critically evaluates the literature on the co-occurrence of substance-use disorders (SUDs) with other psychiatric conditions. Our review considers the variety of different associations between the two, and suggests the implications of the literature for the design of treatment services that address both types of disorders. Methods: A narrative review of research and theory was conducted, covering epidemiology of co-occurring psychiatric disorders worldwide, mechanisms underlying co-occurrence, and treatment models. Results: Epidemiological research has documented a high prevalence of co-occurring disorders in both clinical samples and the general population, although the literature is based primarily on studies in high-income countries and some of the overlap might be due to the co-occurrence of milder forms of both types of disorders. Consistent with what has been reported in other reviews, we conclude that clients with co-occurring disorders tend to have a more severe course of illness, more severe health and social consequences, more difficulties in treatment, and worse treatment outcomes than clients with a single disorder; we address the implications of these findings for the design of treatment services. Conclusions: Much of the evidence shows that separately, treatments for both SUD and other psychiatric disorders are effective in reducing substance use and in improving behavioral, familial, and psychosocial outcomes. The evidence further suggests that these outcomes might be improved when treatment modalities are offered in combination within an integrated treatment plan that simultaneously addresses substance abuse and psychiatric problems. It is concluded that there is potentially more to be gained from taking a public health perspective and working on efforts to implement existing evidence-based practices at the systems level, than from the current tendency to look for ever more powerful individual-level interventions at the clinical level.
Lack of effects of creatine on the regeneration of soleus muscle after injury in rats.

PURPOSE Creatine (Cr) supplementation may improve muscle functional capacity in patients with neuromuscular diseases, disuse atrophy, or muscular dystrophies. Activation of myogenic satellite cells has been reported to be enhanced by Cr both in vitro and in vivo. Therefore, we hypothesized that Cr supplementation may improve the early steps of regeneration after muscle injury and may accelerate the recovery of both muscle mass and phenotype. METHODS Degeneration of left soleus muscle was induced by notexin injection in rats supplemented or not with Cr. The mass of regenerated muscles was compared with contralateral intact muscles at days 1, 3, 7, 14, 21, 28, 35, and 42 after injury. We also studied protein levels of the proliferator cell nuclear antigen (PCNA) as a marker of cell proliferation, expression of myogenic regulatory factors (MRF) as a marker of differentiation, and the myosin heavy chain (MHC) profile and activities of citrate synthase (CS) and lactate dehydrogenase (LDH) isozymes as markers of muscle phenotype maturation. RESULTS Cr supplementation accelerated the recovery of muscle Cr content during the regeneration phase. Although there were no other differences between Cr-treated and nontreated rats, we observed that 1) regenerated muscle mass remained lower than that in intact muscle mass 42 d after injury, 2) PCNA and MRF expression strongly increased in regenerated muscles, 3) the MHC profile of regenerated muscles was recovered 28 d after injury, and 4) CS activity was fully recovered from day 14, whereas the specific H isozyme of lactate dehydrogenase activity remained lower than that in intact muscles until 42 d. CONCLUSIONS In contrast with results from in vitro studies, Cr supplementation had no effects in vivo on the time course of recovery of rat skeletal muscle mass and phenotype after notexin-induced injury.
Comparative efficacy of water and land treadmill training for overweight or obese adults.

PURPOSE No known previous research has been published to explore the efficacy of underwater treadmill (UTM) exercise training for the obese. Thus, the purpose of this study was to compare changes in physical fitness, body weight, and body composition in physically inactive, overweight, and obese adults after 12 wks of land treadmill (LTM) or UTM training. METHODS Fifty-seven physically inactive, overweight, and obese men (n = 25) and women (n = 32) participated in this investigation. The mean +/- SEM age, weight, body mass index (BMI), and V O2max upon entry were 44 +/- 2 yr, 90.5 +/- 2.4 kg, 30.5 +/- 0.7 kg.m, and 27.1 +/- 0.7 mL O2.kg.min, respectively. Subjects were randomly assigned to exercise three times per week for 12 wk on either LTM (n = 29) or UTM (n = 28) matched for intensity and volume. Session volume was progressively increased from 250 to 500 kcal per session by week 6 and remained at 500 kcal through week 12. Before and after training, V O2max was assessed by the Bruce treadmill protocol with open-circuit calorimetry, and body composition was assessed by dual-energy ray absorptiometry. Data were analyzed by a 2 (training) x 2 (exercise mode) x 2 (gender) ANOVA repeated across training (alpha = 0.05). RESULTS Training responses were not different between genders. After either UTM or LTM training, V O2max was significantly increased (+3.6 +/- 0.4 mL O2.kg.min), whereas body weight (-1.2 +/- 0.3 kg), BMI (-0.56 +/- 0.11 kg.m), body fat percentage (-1.3% +/- 1.3%), and fat mass (-1.1 +/- 0.3 kg) were significantly reduced (pooled means for UTM and LTM). Regional leg lean body mass (LBM) was significantly increased with both CTM and UTM (0.4 +/- 0.3 and 0.8 +/- 0.2 kg, respectively). An increase in total LBM approached significance with UTM training only (+0.6 +/- 0.3 kg, P = 0.0599). CONCLUSIONS UTM and LTM training are equally capable of improving aerobic fitness and body composition in physically inactive overweight individuals, but UTM training may induce increases in LBM.
Effects of sit-up training versus core stabilization exercises on sit-up performance.

PURPOSE Core stabilization exercises target abdominal and trunk muscles without the excessive loading that occurs during sit-ups. However, core stabilization exercise programs (CSEP) have not been widely adopted in the US Army partially because of the perceived deleterious impact they would have on performance during the Army Physical Fitness Test. The purpose was to determine whether performing CSEP in lieu of sit-ups during unit physical training would have detrimental effects on sit-up performance and passing rates on the fitness test. METHODS Soldiers (N = 2616) between 18 and 35 yr of age were randomized to receive a traditional exercise program (TEP) with sit-ups or CSEP. Subjects with a previous history of low back pain or other injury precluding participation in training were excluded. The training programs were completed four times per week for 12 wk. Performance was assessed at baseline and after 12 wk. RESULTS Both groups demonstrated significant improvements in sit-up performance and overall fitness scores over time (P < 0.001). There were no significant between-group differences in overall fitness scores (P = 0.142) or sit-up performance (P = 0.543). However, CSEP resulted in a significant improvement in sit-up passing rates by 5.6% compared with 3.9% for the TEP group (P = 0.004). CONCLUSIONS CSEP did not have a detrimental impact on sit-up performance or overall fitness scores or pass rates. There was a small but significantly greater increase in sit-up pass rate in the CSEP (5.6%) versus the TEP group (3.9%). Incorporating CSEP into Army physical training does not increase the risk of suboptimal performance on the Army's fitness test and may offer a small benefit for improving sit-up performance.
It's all about the money – randomised controlled trial of public opinion towards prescribing injectable heroin in drug treatment

Purpose – Injectable opioid therapy (prescribing heroin for heroin addicts to inject) remains a highly controversial and expensive option. Recent research has shown significant benefits for this therapy in otherwise refractory patients. The aim of this paper is to assess the public opinion regarding heroin prescribing to addicts and to determine what effect the cost of this might have on their opinions.Design/methodology/approach – Participants were asked to complete a questionnaire after reading a vignette which described current opioid maintenance therapy. Two vignettes were generated and the experimental group was randomised to receive the additional information that the cost of heroin prescribing was £15,000 per addict, per year.Findings – Questionnaires were received from 187 subjects (response rate 74 percent). For the control group, 23 percent agreed and 58 percent disagreed with prescribing heroin to addicts (23 vs 62). For the experimental group, where the additional cost of £15,000 per addict wa.
Human papillomavirus—the most significant risk determinant of cervical intraepithelial neoplasia

Sexual behavior has been consistently identified as a major risk factor for cervical cancer. Population‐based studies have demonstrated that risk related to sexual activity is mediated by human papillomavirus (HPV) infection. We conducted a case‐control study of 199 cases with low‐grade squamous intraepithelial lesions or high‐grade squamous intraepithelial lesions as defined by cytology and 1000 control women selected from an ongoing prospective cohort study in Copenhagen, Denmark. Furthermore, 131 women with equivocal smears (atypical squamous cells of undetermined significance) were examined as a separate borderline case group. At enrollment, all women had a personal interview and a gynecological examination including cervical swabs for HPV testing and a Pap smear. HPV testing was performed using a combination of general primer 5/6‐mediated and type‐specific polymerase‐chain‐reaction‐based methods. Cervical HPV infection was by far the most significant risk factor for cervical squamous intraepithelial lesions. The relationship with HPV was observed for all grades, while strength of association was greater for more severe lesions. The importance of the previously identified epidemiological risk factors for cervical neoplasia was also demonstrated. However, most of the effect of these factors could be explained by taking HPV infection into account, except for schooling and smoking. Non‐use of barrier contraceptives and smoking were the only significant risk factors in HPV‐positive women. In HPV‐negative women, a residual effect existed for different measures of sexual activity, and use of oral contraceptives and smoking constituted significant risk determinants. Overall, 66% of cases could be attributed to HPV; however, if the results were restricted to histologically confirmed high‐grade lesions, the proportion of cases that could be attributed to HPV infection increased to 80%. © 1996 Wiley‐Liss, Inc.