Miracle-dz/UniFAR-FTUs huggingface dataset:
Fuzzy Multi-class Support Vector Machine Based on Binary Tree in Network Intrusion Detection

Support vector machine(SVM) is sensitive to the noises and outliers in the training samples, so fuzzy support vector machine(FSVM) precede support vector machine in solving the problem of non-linearity high dimension and uncertainty. At the same time, for the practicability, the multi-class support vector machine is a good choice. In this paper, we combine the fuzzy support vector machine and multi-class support vector machine based on binary tree together, and apply it to network intrusion detection system. The experiment shows that the method improves the detection accuracy and reduces the training time.
Isolation and characterization of the nuclear acceptor that binds the progesterone-receptor complex in hen oviduct.

Progesterone binds to the nuclear chromatin of hen oviduct cells within minutes after its administration. This is followed by alterations in the RNA polymerase activities (15–30 min after treatment) and the appearance of specific messenger RNA (2 hr after treatment). It appears that the first nuclear event resulting in changes in gene expression represents the chromatin binding. Further characterization of this nuclear interaction, involving the administration of multiple doses of progesterone to estrogen‐treated immature chicks, revealed the presence of several classes of nuclear binding sites in the oviduct. Comparisons of serum progesterone levels and responses of RNA polymerase I and II activities with the nuclear binding indicated that the highest‐affinity classes of sites (∼ 10,000 sites per cell) are the biologically important ones. Binding studies in vitro, using isolated progesterone‐receptor complex, also reveal the presence of these multiple classes of sites. The highest‐affinity class of nucle.
Retinoic acids up‐regulate functional eosinophil‐driving receptor CCR3

Eotaxins and their receptor CCR3 have a definitive role for tissue accumulation of eosinophils both under homeostatic and pathologic conditions. However, physiological stimuli that can up‐regulate CCR3 in blood‐derived human eosinophils have not been recognized. As a prior gene microarray study revealed up‐regulation of CCR3 in eosinophils stimulated with retinoic acids (RAs), the expression of functional CCR3 was examined. We found that 9‐cis RA and all‐trans RA (ATRA) significantly induced surface CCR3 expression regardless of the presence of IL‐3 or IL‐5. Pharmacological manipulations with receptor‐specific agonists and antagonists indicated that retinoic acid receptor‐α activation is critical for CCR3 up‐regulation. RA‐induced CCR3 was associated with its functional capacity, in terms of the calcium mobilization and chemotactic response to eotaxin‐1 (CCL11). Our study suggests an important role of vitamin A derivatives in the tissue accumulation of eosinophils.
Standardization of the PFA‐100® platelet function test in 105 mmol/l buffered citrate: effect of gender, smoking, and oral contraceptives

The PFA‐100® (PFA) diagnostic system for the detection of platelet dysfunction was evaluated to determine reference ranges in a normal population. The PFA determines the primary haemostasis capacity (PHC) of anticoagulated whole blood, expressed by the system's closure time (CT). In this study the CT reference ranges were determined for blood samples collected in 105 mmol/l (3.2%) buffered citrate and the effect of gender, smoking, and use of oral contraceptives on reference ranges was assessed. Each of the 309 healthy blood donors from five blood centres was confirmed to have normal platelet function before inclusion in the study. Blood samples were tested in duplicate with both the collagen/epinephrine (Col/Epi) and collagen/ADP (Col/ADP) test cartridges.
Domestic cattle as a non-conventional amplifying host of vesicular stomatitis New Jersey virus

The role of vertebrates as amplifying and maintenance hosts for vesicular stomatitis New Jersey virus (VSNJV) remains unclear. Livestock have been considered dead-end hosts because detectable viraemia is absent in VSNJV-infected animals. This study demonstrated two situations in which cattle can represent a source of VSNJV to Simulium vittatum Zetterstedt (Diptera: Simuliidae) by serving: (a) as a substrate for horizontal transmission among co-feeding black flies, and (b) as a source of infection to uninfected black flies feeding on sites where VSNJV-infected black flies have previously fed. Observed co-feeding transmission rates ranged from 0% to 67%. Uninfected flies physically separated from infected flies by a distance of up to 11 cm were able to acquire virus during feeding although the rate of transmission decreased as the distance between infected and uninfected flies increased. Acquisition of VSNJV by uninfected flies feeding on initial inoculation sites at 24 h, 48 h and 72 h post-infection, in both the presence and absence of vesicular lesions, was detected.
The role of myosin 1c and myosin 1b in surfactant exocytosis

ABSTRACT Actin and actin-associated proteins have a pivotal effect on regulated exocytosis in secretory cells and influence pre-fusion as well as post-fusion stages of exocytosis. Actin polymerization on secretory granules during the post-fusion phase (formation of an actin coat) is especially important in cells with large secretory vesicles or poorly soluble secretions. Alveolar type II (ATII) cells secrete hydrophobic lipo-protein surfactant, which does not easily diffuse from fused vesicles. Previous work showed that compression of actin coat is necessary for surfactant extrusion. Here, we investigate the role of class 1 myosins as possible linkers between actin and membranes during exocytosis. Live-cell microscopy showed translocation of fluorescently labeled myosin 1b and myosin 1c to the secretory vesicle membrane after fusion. Myosin 1c translocation was dependent on its pleckstrin homology domain. Expression of myosin 1b and myosin 1c constructs influenced vesicle compression rate, whereas only the inhibition of myosin 1c reduced exocytosis. These findings suggest that class 1 myosins participate in several stages of ATII cell exocytosis and link actin coats to the secretory vesicle membrane to influence vesicle compression. Summary: Myosin 1b and 1c localize to fused secretory vesicles and influence the compression of the actin coat during exocytosis.
External marker‐based automatic congruencing: A new method of 3D reconstruction from serial sections

Computer‐based three‐dimensional (3D) visualizations reconstructed from sectional images represent a valuable tool in biomedical research and medical diagnosis. Particularly with those imaging techniques that provide virtual sections, such as CT, MRI, and CLSM, 3D reconstructions have become routine. Reconstructions from physical sections, such as those used in histological preparations, have not experienced an equivalent breakthrough, due to inherent shortcomings in sectional preparation that impede automated image‐processing and reconstruction. The increased use of molecular techniques in morphological research, however, generates an overwhelming amount of 3D molecular information, stored within series of physical sections. This valuable information can be fully appreciated and interpreted only through an adequate method of 3D visualization.
PHYSICAL THERAPY ROLES IN COMMUNITY-BASED REHABILITATION : A CASE STUDY IN RURAL AREAS OF NORTH EASTERN THAILAND

This action research aimed to explore how physical therapists could enhance the quality of life for persons with disabilities via a community-based rehabilitation (CBR) strategy. The study was conducted in two rural sub-districts in northeastern Thailand. In each sub-district, several group meetings were arranged for persons with disabilities and their families, and various community members. Participants were encouraged to discuss their perception of problems of the current rehabilitation services for persons with disabilities. Strategies to manage all problems were collaboratively identified and were implemented in order of priority according to the importance of the problem. The outputs of CBR were evaluated by interviews and observation. The findings revealed that physical therapists had numerous roles in CBR, depending on the community’s circumstances. They need a high degree of flexibility and a wide range of skills to contribute to CBR. The preparation of such physical therapists requires development of a more client-centered community-oriented education programme.
Comparison of enrichment methods and atmosphere modification procedures for isolating Campylobacter jejuni from foods

A comparison was made of enrichment broths for recovery of Campylobacter jejuni from food by the methods of Doyle and Roman (Appl. Environ. Microbiol. 43:1343-1353) and of Park et al. (Can. J. Microbiol. 27:841-842). No significant differences were found between the results obtained with the two broths. Recovery was greater, however, with a constant gas flow into the broths than with an evacuation-replacement method.
Reduction of the parahippocampal gyrus and the hippocampus in patients with chronic schizophrenia

Background There have been many studies reporting reduced volume of the hippocampus or other limbic structures in patients with schizophrenia, but the literature is inconsistent. Aims To compare patients with either first-episode or chronic schizophrenia with controls using high-resolution volumetric magnetic resonance imaging (MRI) scans. Method Thirteen patients with first-episode schizophrenia, 27 with chronic schizophrenia and 31 controls had 1.5 mm coronal slices taken through the whole brain using a spoiled-grass MRI acquisition protocol. Results The parahippocampal gyrus was reduced significantly on the left side in patients with chronic schizophrenia compared with controls for both male and female patients, whereas the hippocampus was reduced significantly on both sides only in female patients. There were no significant reductions in any structure between patients with first-episode schizophrenia and controls. Conclusions Volumetric reduction seen in patients with chronic schizophrenia may be due to an active degenerative process occurring after the onset of illness.
Colour, fat and social status in male damselflies, Calopteryx maculata


In the black-winged damselfly, Calopteryx maculata, younger males challenge and displace older males from mating territories. Fatter males tend to win fights. These fights were initially interpreted as wars of attrition based on fat reserves, but the distributions of fat at the end of fights suggests at least some assessment of the opponent's condition. Alternatively, new models have been developed that show how the observed pattern could result without assessment. We show that there is a subtle but reliable cue to fat reserves: colour. Females are a relatively drab brown-black. Males are a strikingly iridescent blue-green colour, resulting from a multilayer constructive interference reflector system in the epicuticle. In fatter males the lamellae are more compressed and the peak reflectance is at shorter wavelengths (blue). Leaner, greener males have greater spacing between lamellae and reflect longer wavelengths. The peak reflectance is as predicted from transmission electron micrograph measurements of the lamellar spacing. The rate of change in spacing over time can be manipulated experimentally by manipulating the diet. Individuals on a higher food diet remained blue longer and at the end of the experiment were fatter and bluer. In our studies, colour is a better predictor of territorial status than fat. Copyright 2000 The Association for the Study of Animal Behaviour.
Astrocytic cytoskeletal atrophy in the medial prefrontal cortex of a triple transgenic mouse model of Alzheimer’s disease

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by the loss of cognitive functions, reflecting pathological damage to the medial prefrontal cortex (mPFC) as well as to the hippocampus and the entorhinal cortex. Astrocytes maintain the internal homeostasis of the CNS and are fundamentally involved in neuropathological processes, including AD. Here, we analysed the astrocytic cytoskeletal changes within the mPFC of a triple transgenic mouse model of AD (3 × Tg‐AD) by measuring the surface area and volume of glial fibrillary acidic protein (GFAP)‐positive profiles in relation to the build‐up and presence of amyloid‐β (Aβ), and compared the results with those found in non‐transgenic control animals at different ages. 3 × Tg‐AD animals showed clear astroglial cytoskeletal atrophy, which appeared at an early age (3 months; 33% and 47% decrease in GFAP‐positive surface area and volume, respectively) and remained throughout the disease progression at 9, 12 and 18 months old (29% and 36%; 37% and 35%; 43% and 37%, respectively). This atrophy was independent of Aβ accumulation, as only a few GFAP‐positive cells were localized around Aβ aggregates, which suggests no direct relationship with Aβ toxicity. Thus, our results indicate that the progressive reduction in astrocytic branching and domain in the mPFC can account for the integrative dysfunction leading to the cognitive deficits and memory disturbances observed in AD.
Management and results of localized Ewing's sarcoma

Seventy‐six patients with localized Ewing's sarcoma who received primary treatment at M. D. Anderson Hospital from 1948 through December 1975 were reviewed. Patients have been divided into four groups according to the different treatment regimens they received: Group I, moderate dose radiotherapy alone; Group II, high dose radiotherapy alone; Group III, radiotherapy plus vincristine and cytoxan; and Group IV, radiotherapy plus vincristine, Adriamycin, cytoxan and actinomycin. The problem of local recurrence appears to be solved with combined chemotherapy and radiation therapy with only one of 36 patients having a recurrence at the primary site in Groups III and IV. Multimodal therapy is the preferred treatment to obtain control of the primary lesion by radiation therapy while preserving good function. However, the major cause of failure remains distant metastases, 19 of 36 (53%) in Groups III and IV. In addition, 4 of 10 patients who have survived over 5 years have developed osteogenic sarcoma. Cancer 43:1001–1006, 1979.
Use of the ICD-10 version of the Standardized Assessment of Personality to determine the prevalence of personality disorder in psychiatric in-patients

Synopsis The Standardized Assessment of Personality (SAP) involves a short semi-structured interview with an informant. It was modified to accord with the 1987 draft of the tenth revision of the International Classification of Diseases (ICD-10) and used to assess the pre-morbid personality of first-admission patients in one London area over the period of one year. Of the 120 (84% of the total sample of first-admissions) patients included, 43 (36%) were found to satisfy the ICD-10 criteria for personality disorder and a further 17 (14%) to satisfy the criteria for personality trait accentuation.
Bioluminescence screening in vitro (Bio-Siv) assays for high-volume antimycobacterial drug discovery

Bioluminescence-based assays to indicate antimicrobial susceptibility have been developed and validated for recombinant strains of Mycobacterium tuberculosis, Mycobacterium bovis BCG, Mycobacterium avium, and Mycobacterium intracellulare expressing an integrated eukaryotic luciferase gene. MICs determined with these bioluminescence assays for several antimycobacterial agents, including isoniazid, ethambutol, rifampin, amikacin, streptomycin, ciprofloxacin, and clarithromycin, compared favorably with traditional BACTEC methods and visual estimations of the inhibitory end point. Assay methodology has been optimized for the analysis of large numbers of novel compounds and is simple, inexpensive, and labor efficient. The availability of these four recombinant mycobacteria has permitted a strategy for drug discovery employing the nonpathogenic BCG strain for mass screening purposes with subsequent confirmation of activity against the pathogenic mycobacteria. Furthermore, evidence suggests that the BCG-based screen may allow the direct identification of bactericidal agents.
The effect of non-specific tight junction modulators on the transepithelial transport of poorly permeable drugs across airway epithelial cells

Abstract The epithelial barrier in the respiratory system is a major obstacle for drug delivery to the systemic circulation in the lung. Epithelial barrier hinders the transport of large macromolecules or polar drugs. Essential components of this epithelial fence are physical intercellular structures termed tight junctions. Therefore, modulating tight junctions can enhance paracellular transport across epithelial barrier. In this study, the effect of some of non-specific tight junction modulators (TJMs); (Sodium (Na) decanoate, oleic acid and ethyleneglycol-bis-(β-aminoethyl ether)-N, N′-tetraacetic acid (EGTA)) with established effect on intestinal tight junctions was evaluated for its effects on bronchial epithelial cells (Calu-3 cells). It was demonstrated that the effect of TJMs especially Na decanoate resulted in a reversible opening of tight junctions evidenced by the decrease in the transepithelial resistance. It was also demonstrated that this reduction of TEER upon exposing the epithelial cells to the TJMs resulted in a significant increase in Flu-Na (paracellular marker) and PXS25 (anti-fibrotic compound) transepithelial transport through this barrier. In conclusion, among the investigated non-specific TJMs, Na decanoate fulfilled the requirements of an effective, non-toxic and reversible tight junction modulator for Calu-3 lung epithelial cells.
Hypernatremia in the critically ill is an independent risk factor for mortality.

BACKGROUND Hypernatremia is common in the intensive care unit (ICU). We assessed the prevalence of hypernatremia and its impact on mortality and ICU length of stay (LOS). STUDY DESIGN Retrospective analysis. SETTING & PARTICIPANTS All patients admitted to a medical ICU of a university hospital during a 35-month observation period. PREDICTOR Hypernatremia (serum sodium > 149 mmol/L) after admission to the ICU. OUTCOMES & MEASUREMENTS Main outcomes were 28-day hospital mortality and ICU LOS. Demographic factors, main diagnosis, and severity of illness. Cox proportional hazards regression models were used for data analysis. RESULTS Of 981 patients, 90 (9%) had hypernatremia, on admission to the ICU in 21 (2%) and developed during the ICU stay in 69 patients (7%). Of these 981 patients, 235 (24%) died; LOS was 8 +/- 9 (SD) days. Mortality rates were 39% and 43% in patients with hypernatremia on admission or that developed after admission compared with 24% in patients without hypernatremia (P < 0.01). LOS was 20 +/- 16 days in patients with hypernatremia compared with 8 +/- 10 days in patients without hypernatremia (P < 0.001). In multivariable analysis, hypernatremia was an independent risk factor for mortality (relative risk, 2.1; 95% confidence interval, 1.4 to 3.3). LIMITATIONS Retrospective design, absence of data for long-term mortality. CONCLUSIONS Most cases of hypernatremia in the ICU developed after admission, suggesting an iatrogenic component in its evolution. Hypernatremia is associated with increased mortality. Strategies for preventing hypernatremia in the ICU should be encouraged.
Double objective optimal multivariable ripple-free deadbeat control

This paper presents novel results on optimal multivariable deadbeat control. Given a discrete-time, stable, linear, time invariant plant model, we give a simple parameterization of all stabilizing ripple-free deadbeat controllers of a given order. The free parameter is then optimized in the sense that a quadratic index is kept minimal. The optimality criterion has the advantage of accounting for both tracking performance and magnitude of the control effort. The proposed design procedure is simple to use and allows the tuning of the controller with a scalar weighting factor. Simulation results are included to illustrate the effectiveness of the proposed design algorithm.
Amniotic fluid epidermal growth factor concentrations

Intra‐amniotic thyroxine (200–500 ug) was administered weekly to 29 women in the third trimester to enhance fetal maturation. Lecithin‐sphingomyelin ratio (L/S) and epidermal growth factor (EGF) were measured in amniotic fluid (AF) before (n = 58) and after (n = 92) administration of thyroxine. The AF L/S ratio and EGF concentration increased linearly with increasing gestational age both before (r = 0.76, p > 0.0001; r = 0.41, p > 0.001, respectively) and after (r = 0.62, p > 0.0001; r = 0.43, p > 0.001 respectively) initiation of thyroxine treatment. The slopes of gestational age vs L/S (0.07) and EGF (0.004) before T4 increased significantly after initiation of T4 therapy (L/S:0.23, p > 0.001; EGF:0.015, p > 0.01, respectively). L/S ratios correlated with AF EGF levels before (r = 0.77, p > 0.001) and after (r = 0.63, p > 0.001) initiation of T4 therapy. These results demonstrate that intra‐amniotic thyroxine accelerates not only the progression of the amniotic fluid L/S ratio, but the appearance of EGF.
Sibling Conversations about Dating and Sexuality: Sisters as Confidants, Sources of Support, and Mentors.

Using an observational methodology to examine sibling communication, sisters (N = 28 dyads) were videotaped discussing their ideas about dating and sexuality. Social provision theory was used as a framework for the examination of roles enacted by sisters during these conversations. Inductive thematic analytic procedures were conducted and three roles were identified: sisters as confidants, sources of support, and mentors. Older and younger sisters both served as confidants and sources of support for one another, whereas, older sisters were more likely to be mentors for their younger sisters than vice versa. Findings indicate the potential importance of sisters in the formation of adolescent girls' ideas about romantic relationships and sexuality, sibling communication as a socialization mechanism of sisters' similarities in romantic experiences and sexual behaviors/attitudes, and the inclusion of older sisters in prevention intervention programs focused on reducing adolescent sexual risk behaviors and promoting healthy romantic relationships and sexuality development.