Miracle-dz/UniFAR-FTUs huggingface dataset:
Correlation between the four types of acromion and the existence of enthesophytes: A study on 423 dried scapulas and review of the literature

The purpose of this study was to correlate the four types of acromial shape with the existence of enthesophytes, which together comprise two important parameters for subacromial impingement syndrome and rotator cuff tears. In addition, a review of the literature was carried out. Four hundred twenty‐three dried scapulas were studied at the Department of Anatomy in the University of Cologne, Germany. Four types of acromion were found: the three classical ones as described by Bigliani et al. ([ 1986 ] Orthop Trans 10:216) and a fourth one, where the middle third of the undersurface of acromion was convex (Gagey et al. [ 1993 ] Surg Radiol Anat 15:63–70). The correlation between the four types of acromion and the presence of enthesophytes at its anterior undersurface was also recorded. The distribution of acromial types was as follows: type I, flat, 51 (12.1%); type II, curved, 239 (56.5%); type III, hooked, 122 (28.8%); and type IV, convex, 11 (2.6%). Enthesophytes were found in 1 of type I (2%), in 19 of type II (7.9%), in 46 of type III (37.7%), and in 0 (0%) of type IV acromions. Overall, 66 (15.6%) out of 423 scapulas had enthesophytes. In all cases, they were localized at the site of the coracoacromial ligament insertion on the acromion. Enthesophytes were significantly (P < 0.05) more common in type III acromions and this combination is particularly associated with subacromial impingement syndrome and rotator cuff tears. In type I and in type IV acromions, the incidence of enthesophytes is very small and, according to other studies, with these two acromial types rotator cuff tears are also rare. Clin Anat. 20:267–272, 2007. © 2006 Wiley‐Liss, Inc.
Effect of depression care on outcomes in COPD patients with depression.

BACKGROUND Although depression among COPD patients is a common problem with important consequences for the management of COPD and overall outcomes, the proportion of those who receive guideline-concordant depression care is low. Guideline-concordant depression care is associated with fewer depressive symptoms and lower risk for psychiatric hospitalization; however, it is unknown whether guideline-concordant depression care favorably impacts COPD-related outcomes for patients with both conditions. METHODS This retrospective cohort study investigated 5,517 veterans with COPD who experienced a new treatment episode for depression. Guideline-concordant depression care was defined as having an adequate supply of antidepressant medication and sufficient follow-up care. Multivariate methods were used to examine the relationship between the receipt of guideline-concordant depression care and (1) COPD-related hospitalization and (2) all-cause mortality 2 years after the depression episode, while controlling for care setting and other covariates. RESULTS There was no association between the receipt of guideline-concordant depression care and COPD-related hospitalization (odds ratio [OR], 0.98) or all-cause mortality (OR, 0.95). However, patients seen in mental health settings during their depressive episode had 30% lower odds of 2-year mortality than patients seen in primary care. CONCLUSIONS For patients with COPD and depression, interacting with a mental health professional may be an important intervention. However, receiving guideline-concordant depression care, as outlined in common quality monitors, was not significantly associated with decreased hospitalization or mortality. These findings suggest that more referrals to specialty care or better care coordination with mental health specialty care may lead to a significant reduction in mortality risk for these patients.
Institutional dynamics in IT markets: extending the concept of organizing visions for IT innovations

iv Chapter 1: Introduction . 1 Research Motivation and Objectives. 1 Thesis Structure. 4 Review of Macro-Level Diffusion Research . 5 Rational Actor Perspective . 6 Institutional Perspective . 8 Relational Models. 13 Chapter 2: Organizing Visions for IT Innovations and Industry Belief Systems . 15 IT Innovation Diffusion and Industry . 15 Levels of Analysis. 19 The Domain of Information Technology . 21 Organizing Visions for IT Innovations. 21 Limitations of the Organizing Vision Framework . 23 The Domain of Industry . 27 Industry Belief Systems. 27 Extending the Industry Belief Framework – The Dual Role of Product Ontologies . 30 Bringing the Elements Together: Organizing Vision Lifecycle. 34 Stage 1: Organizing Vision as Theorization. 37 Stage 2: Organizing Vision as Product Ontology. 43 Stage 3: Organizing Vision as IT-Enabled Industry Recipe. 48 Chapter 3: Organizing Visions for IT Innovations and Legitimacy . 52 Legitimation Function of Organizing Visions . 53 Characteristics of Legitimacy. 56 Strategic and Institutional Approaches to Legitimacy . 57 Key Properties of Legitimacy. 58 Forms of legitimacy . 60 Cognitive Legitimacy . 60 Pragmatic Legitimacy. 62 Normative Legitimacy. 63 Regulative Legitimacy. 64 Socio-Political Legitimacy . 64 Legitimation Strategies . 65 Chapter 4: Case Study – Building Legitimacy for IT Innovations . 69 Case Description . 69 Data Collection. 70 Data Analysis . 71 Phase I: Construction of the Legitimation Taxonomy. 72 Phase II: Evaluation of Legitimation Patterns. 73 Results and Discussion. 74 ii Phase I: Construction of the Legitimation Taxonomy. 74 Phase II: Evaluation of Legitimation Patterns. 92 Chapter 5: Conclusions and Implications . 105 Contributions and Future Research Directions . 106 Research Stream I: Organizing Visions and Industry Belief Systems . 106 Research Stream II: Organizing Visions and Legitimacy . 111 Connections between Research Stream I and Research Stream II . 115 Research Limitations. 117 Implications for Practice . 119 References. 121 Appendix A: Cultural-Cognitive Model of IT-Industry Interaction (CMITII). 130 Appendix B: IT Legitimation Taxonomy . 132 Vita. 144
Microalbuminuria and mortality in long-duration type 1 diabetes.

OBJECTIVE Microalbuminuria is a recognized risk factor for increased mortality and renal failure in type 1 diabetes. Whether it remains a powerful predictor in patients with a long duration of type 1 diabetes is not known. We ascertained the prognostic significance of abnormal urinary albumin excretion in a cohort of patients with at least 30 years of type 1 diabetes. RESEARCH DESIGN AND METHODS A total of 190 patients with a disease duration of type 1 diabetes of at least 30 years with baseline and 5 years of follow-up. RESULTS At baseline 66% were normoalbuminuric, and at 5 years 11% of this cohort had died. Of the 22% who were microalbuminuric at baseline, 26% had died, and of the 8% with persistent proteinuria at baseline, 44% had died. Of the 4% with end-stage renal failure at baseline, 71% had died within 5 years. Death was attributable to a cardiovascular cause in two-thirds of the cases in all groups. CONCLUSIONS Even in those with a long duration of type 1 diabetes, the presence of abnormal urinary excretion remains a powerful predictor of increased mortality.
Interactions between benzylamiloride and fura-2: studies in vitro and in cardiac myocytes.

Amiloride derivatives are commonly used inhibitors of Na+/H+- and Na+/Ca2+-exchange. Because they are fluorescent molecules the use of benzylamiloride (BZA), an inhibitor of Na+/Ca2+ exchange, in conjunction with Fura-2, a commonly used fluorescent Ca2+ indicator, might complicate interpretation of fluorescence data obtained. In vitro data show that BZA decreases the Fura-2 fluorescence at all useful wavelengths in a concentration-dependent manner. The Fura-2 ratio 340/380 (used to estimate intracellular Ca2+ ([Ca2+]in)) also decreased with increasing BZA concentrations. The Stern-Volmer relation suggests that this phenomenon is due to either static or dynamic quenching. Varying temperatures from 4 to 37 degreesC did not alter Stern-Volmer constants, consistent instead with fluorescence resonance energy transfer (FRET). The in situ relevance of these interactions was evaluated in adult rat cardiac myocytes which exhibit Na+/Ca2+ exchange reflected by rapid [Ca2+]in increase following Na+ removal. Pretreatment with BZA >/= 25 microM decreased the magnitude of Fura-2 changes induced by Na+ removal. Analysis of the individual Fura-2 useful wavelengths indicated that >/= 25 microM BZA altered the Fura-2 signal in a manner consistent with the quenching effects noted in vitro. Together, these data show that BZA interacts with Fura-2 in vitro and in situ and suggest caution when interpreting Fura-2 fluorescence data derived in conjunction with BZA.
Changes in the incidence of gastroenteritis and the implementation of public water treatment

There are few data available on the incidence of endemic waterborne disease in the developed world. This study aims to determine if there was a measurable decline in gastroenteritis related faecal specimens following the introduction of water treatment. The rate of faecal specimens for gastroenteritis was obtained for 17 communities one year before and after the introduction of water treatment in two states of Australia between 1992 and 1996. Of these 17 systems, 10 had filtration added to existing disinfection, while seven had both disinfection and filtration or disinfection alone added to no existing treatment. The rate of faecal sampling varied from a reduction of 55% to an increase of 198%. Large changes in water quality parameters occurred following treatment but there was no significant correlation between these changes and changes in the rate of faecal specimens. In this study there was no consistent change in gastrointestinal related faecal specimens despite marked changes in water quality. This suggests that the reduction in endemic gastrointestinal disease as a result of the introduction of water treatment was small as a percentage of all gastroenteritis. However, water treatment remains essential to protecting public health.
A novel concept for a lithium lens exciter

A new circuit concept for the exciter to produce a 100-kA current pulse with a 1-ms flat top is presented. In every half-cycle a capacitor generates a current pulse. A thyristor-controlled rectifier charges the capacitor to the supply voltage, and a thyristor switch discharges it through a pulse transformer which supplies the lens. A zinc-oxide surge arrester, connected in parallel with the pulse transformer, produces the current flat top. The control of a larger current pulse with a nonlinear component improves the lens performance. The exciter can be built with commercially available components. <<ETX>>
Assessment of the performances of multilayer perceptron neural networks in comparison with recurrent neural networks and two statistical methods for diagnosing coronary artery disease

Abstract: We aimed to examine the diagnostic performances of multilayer perceptron neural networks (MLPNNs) for predicting coronary artery disease and to compare them with different types of artificial neural network methods, namely recurrent neural networks (RNNs) and two statistical methods (quadratic discriminant analysis (QDA) and logistic regression (LR)). MLPNNs were trained with backpropagation, quick propagation, delta‐bar‐delta and extended delta‐bar‐delta algorithms as classifiers; the RNN was trained with the Levenberg–Marquardt algorithm; LR and QDA were used for predicting coronary artery disease. Coronary artery disease was classified with accuracy rates varying from 79.9% to 83.9% by MLPNNs. Even though MLPNNs achieved higher accuracy rates than the statistical methods, LR (73.2%) and QDA (58.4%), their performances were lower compared to the RNN (84.7%). Among the four different types of training algorithms that trained MLPNNs, quick propagation achieved the highest accuracy rate; however, it was lower than the RNN trained with the Levenberg–Marquardt algorithm. RNNs, which demonstrated 84.7% accuracy and 86.5% positive predictive rates, may be a helpful tool in medical decision making for diagnosis of coronary artery disease.
Treatment Costs and Survival in Patients with Grades III-IV Acute Graft-Versus-Host Disease after Allogenic Hematopoietic Stem Cell Transplantation During Three Decades

To determine development of treatment, costs, and survival for patients with grades III/IV acute graft-versus-host disease (GVHD), data from 88 patients with grades III/IV acute GVHD were collected. The patients were divided into three groups: patients who received transplants from 1977 through 1989 (group A), 1990 through 1999 (group B), and 2000 through 2004 (group C). The costs for treatment, enumerated to year 2003 costs, were calculated. An increased 1-year survival rate was found in group C, at 21% versus 9% and 8% for groups A and B, respectively (P=0.02). Death by acute GVHD was increased by repeat transplantation (P<0.001), grade IV acute GVHD (P<0.001), human leukocyte antigen mismatch (P=0.009), and transplantation before 2000 (P=0.015). Transplantation after 1990 (P=0.003) and grade IV acute GVHD (P=0.03) were associated with higher treatment costs. It was found that the time the patients had GVHD did not differ among the three groups. In conclusion, the costs and survival rates associated with severe acute GVHD has increased in recent years.
Spanish Agriculture and Water: Educational Implications of Water Culture and Consumption from the Farmers’ Perspective

The responsible management and consumption of water is a challenge that involves all segments of society. Having access to sufficient quality and quantity of water is not only a technological issue, but requires that the adopted measures and programmes take into account the dimensions of society and education. Spanish agriculture, as in other areas of the world, is a major consumer of water and more so than other sectors, including household consumption. Within the field of environmental education, this study covered the water culture and consumption of Andalusian farmers, based on their own perceptions. For this purpose, a questionnaire was created and validated, and included a sample of 1030 farmers selected with pseudorandom number sampling. An analysis of the data showed relevant results with respect to the values and notions supporting the justification for farmer behaviours, both from a cognitive-representative viewpoint and from an affective-expressive stance, as well as assertions made by the irrigators about other key sectors concerning the responsible management of water usage and water consumption. The findings of this study may assist in the design of environmental education programmes addressing this sector, which could also include other similar populations.
A capacitor-less 1T-DRAM cell

A simple true 1 transistor dynamic random access memory (DRAM) cell concept is proposed for the first time, using the body charging of partially-depleted SOI devices to store the logic "1" or "0" binary states. This cell is two times smaller in area than the conventional 8F/sup 2/ 1T/1C DRAM cell and the process of its manufacturing does not require the storage capacitor fabrication steps. This concept will allow the manufacture of simple low cost DRAM and embedded DRAM chips for 100 and sub-100 nm generations.
The effect of induced hindlimb lameness on thoracolumbar kinematics during treadmill locomotion.

REASON FOR PERFORMING STUDY There are no detailed studies describing a relationship between hindlimb lameness and altered motion of the back. OBJECTIVES To quantify the effect of induced subtle hindlimb lameness on thoracolumbar kinematics in the horse. METHODS Kinematics of 6 riding horses were measured during walk and trot on a treadmill before and during application of pressure on the sole of the left hindlimb using a well-established sole pressure model. Reflective markers were located at anatomical landmarks on the limbs, back, head and neck for kinematic recordings. Ground reaction forces (GRF) in individual limbs were calculated from kinematics to detect changes in loading of the limbs. RESULTS When pressure on the sole of the hindlimb was present, horses were judged as lame (grade 2 on the AAEP scale 1-5) by an experienced clinician. No significant unloading of this limb was found in the group of horses (unloading was observed in 4 animals, but was not detectable in the other 2), but statistically significant effects on back kinematics were detected. The overall flexion-extension (FE) range of motion (ROM) of the vertebral column was increased at walk, especially in the thoracic segments. Axial rotation (AR) ROM of the pelvis was also increased. At trot, the FE ROM was decreased only in the segment L3-L5-S3. During the stance phase of the lame limb, the segment T6-T10-T13 was more flexed and the neck was lowered at both gaits; the thoracolumbar segments were more extended at walk and trot. There were no significant changes in the stride length or protraction-retraction angles in any of the limbs. CONCLUSIONS Subtle hindlimb lameness provoked slight but detectable changes in thoracolumbar kinematics. The subtle lameness induced in this study resulted in hyperextension and increased ROM of the thoracolumbar back, but also in decreased ROM of the lumbosacral segment and rotational motion changes of the pelvis. POTENTIAL RELEVANCE Even subtle lameness can result in changes in back kinematics, which emphasises the intricate link between limb function and thoracolumbar motion. It may be surmised that, when chronically present, subtle lameness induces back dysfunction.
Autophagy impairment mediated by S-nitrosation of ATG4B leads to neurotoxicity in response to hyperglycemia

ABSTRACT The majority of diabetic patients develop neuropathy and there is an increasing prevalence of neurodegeneration in the central nervous system (CNS). However, the mechanism behind this is poorly understood. Here we first observed that macroautophagy/autophagy was suppressed in the hippocampus of diabetic GK rats with hyperglycemia, whereas it was unchanged in ob/ob mice without hyperglycemia. Autophagy could be directly inhibited by high glucose in mouse primary hippocampal neurons. Moreover, autophagy was protective in high-glucose-induced neurotoxicity. Further studies revealed that autophagic flux was suppressed by high glucose due to impaired autophagosome synthesis illustrated by mRFP-GFP-LC3 puncta analysis. We showed that decreased autophagy was dependent on NO produced under high glucose conditions. Therefore, (LC-MS/MS)-based quantitative proteomic analysis of protein S-nitrosation was performed and a core autophagy protein, ATG4B was found to be S-nitrosated in the hippocampus of GK rats. ATG4B was also verified to be S-nitrosated in neuronal cells cultured with high glucose. The activities of ATG4B in the processing of unmodified, precursor Atg8-family proteins and in the deconjugation of PE from lipidated Atg8-family proteins, which are essential for efficient autophagosome biogenesis were both compromised by S-nitrosation at Cys189 and Cys292 sites. In addition, ATG4B processing of the GABARAPL1 precursor was affected the least by S-nitrosation compared with other substrates. Finally, ATG4B S-nitrosation was verified to be responsible for decreased autophagy and neurotoxicity in response to high glucose. In conclusion, autophagy impairment mediated by S-nitrosation of ATG4B leads to neurotoxicity in response to hyperglycemia. Our research reveals a novel mechanism linking hyperglycemia with CNS neurotoxicity and shows that S-nitrosation is a novel post-transcriptional modification of the core autophagy machinery.
Selective internalization of self-assembled artificial oil bodies by HER2/neu-positive cells

A novel delivery carrier was developed using artificial oil bodies (AOBs). Plant seed oil bodies (OBs) consist of a triacylglycerol matrix surrounded by a monolayer of phospholipids embedded with the storage protein oleosin (Ole). Ole consists of a central hydrophobic domain with two amphiphatic arms that extrude from the surface of OBs. In this study, a bivalent anti-HER2/neu affibody domain (ZH2) was fused with Ole at the C terminus. After overproduction in Escherichia coli, the fusion protein (Ole-ZH2) was recovered to assemble AOBs. The size of self-assembled AOBs was tailored by varying the oil/Ole-ZH2 ratio and pH to reach a nanoscale. Upon co-incubation with tumor cells, the nanoscale AOBs encapsulated with a hydrophobic fluorescence dye were selectively internalized by HER2/neu-overexpressing cells and displayed biocompatibility with the cells. In addition, the ZH2-mediated endosomal entry of AOBs occurred in a time- and AOB dose-dependent manner. The internalization efficiency was as high as 90%. The internalized AOBs disintegrated at the non-permissive pH (e.g. in acidic endosomes) and the cargo dye was released. Results of in vitro study revealed a sustained and prolonged release profile. Taken together, our findings indicate the potential of AOBs as a delivery carrier.
Translation and adaptation of the Pediatric Outcome Data Collecting Instrument (PODCI) into the Dutch language and preliminary validation in children with Neonatal Brachial Plexus Palsy.

PURPOSE This study aimed to translate and cross-culturally adapt the Pediatric Outcome Data Collecting Instrument (PODCI) into the Dutch language and evaluate its measurement properties among children (age 3-10) with Neonatal Brachial Plexus Palsy (NBPP). METHODS The PODCI was translated and adapted according to international guidelines and administered to 10 children with NBPP before and after surgery and thereafter twice again. Subsequently, the Mallet-score, Assisting Hand Assessment and active Range of Motion (aROM) were recorded. Cronbach's-α and correlations between the PODCI and other outcome measures were determined, as well as Intraclass Correlation Coefficients (ICC). In addition, effect sizes (ES), Standard Response Means (SRM) and change scores with the 95% Confidence Interval (95% CI) were calculated. RESULTS The final Dutch PODCI `Upper Extremity and Physical Function' subscale and total score `Global Functioning' showed good internal consistency (Cronbach's-α 0.695/0.781) and reliability (ICC 0.97/0.80) and were significantly associated with aROM and the Mallet-score. After surgery a significant change of the total score (ES 0.57, SRM 1.23, change 4.22 points, 95% CI 1.04-7.4) was seen. CONCLUSION The final Dutch PODCI had good measurement properties and appears useful in evaluating quality of life and functioning in children with NBPP.
Dynamics of the Early Immune Cellular Reactions after Myogenic Cell Transplantation

The role of immune cells in the early donor cell death/survival following myoblast transplantation is confusing, one of the reasons being the lack of data about the immune reactions following cell transplantation. We used outbred mice as hosts for transplantation of primary cultured muscle cells and T-antigen-immortalized myoblasts. The host muscles were analyzed 1 h to 7 days after cell injection. No net loss of the donor primary cultured cell population was observed in this period. The immune cellular reaction in this case was: 1) a brief (<48 h) neutrophil invasion; 2) macrophage infiltration from days 1 to 7; 3) a specific response involving CTL and few NK cells (days 6 and 7), preceded by a low CD4+ cell infiltration starting at day 3. In contrast, donor-immortalized myoblasts completely disappeared during the 7-day follow-up. In this case, an intense infiltration of CTL and macrophages, with moderate CD4+ infiltration and lower amounts of NK cells, was observed starting at day 2. The nonspecific immune response at days 0 and 1 was similar for both types of donor cells. The present observations set a basis to interpret the role of immune cells on the early death/survival of donor cells following myoblast transplantation.