Miracle-dz/UniFAR-FTUs huggingface dataset:
Maternal reflective functioning among mothers with childhood maltreatment histories: links to sensitive parenting and infant attachment security

This study examined relationships among maternal reflective functioning, parenting, infant attachment, and demographic risk in a relatively large (N = 83) socioeconomically diverse sample of women with and without a history of childhood maltreatment and their infants. Most prior research on parental reflective functioning has utilized small homogenous samples. Reflective functioning was assessed with the Parent Development Interview, parenting was coded from videotaped mother–child interactions, and infant attachment was evaluated in Ainsworth’s Strange Situation by independent teams of reliable coders masked to maternal history. Reflective functioning was associated with parenting sensitivity and secure attachment, and inversely associated with demographic risk and parenting negativity; however, it was not associated with maternal maltreatment history or PTSD. Parenting sensitivity mediated the relationship between reflective functioning and infant attachment, controlling for demographic risk. Findings are discussed in the context of prior research on reflective functioning and the importance of targeting reflective functioning in interventions.
Can Shoulder Muscle Coordination During the Support Scale at Ring Height be Replicated During Training Exercises in Gymnastics?

Bernasconi, SM, Tordi, NR, Parratte, BM, and Rouillon, J-DR. Can shoulder muscle coordination during the support scale at ring height be replicated during training exercises in gymnastics? J Strength Cond Res 23(8): 2381-2388, 2009-The support scale at ring height, the swallow, is a difficult strength element, usually performed in gymnastics. Coaches try to simulate the swallow position during training to strengthen muscles, specifically in the position used for competition. However, the real effect of this position's simulation on muscle force and coordination and consequently on the muscle activity has not been determined. The purpose of the study was to compare muscle activity and coordination during a swallow performed on the rings, using a counterweight and during 2 training exercises using dumbbells or barbells, respectively. Six top-level gymnasts participated in the study. Electromyograms from the biceps brachii, triceps brachii, deltoideus (clavicular part), pectoralis major, serratus anterior, infraspinatus, trapezius (middle part), and latissimus dorsi in the right shoulder were collected during the 4 exercises and analyzed using root mean square (RMS) and mean power frequency (MPF). The RMS were normalized to the maximal voluntary contraction, and a co-activation index was also determined between biceps and triceps brachii. Our results show specific shoulder muscle coordination for each exercise. As compared with the swallow on the rings, the pectoralis major participates less in shoulder flexion during the counterweight exercise, whereas the deltoideus is more activated during the dumbbells exercise (p < 0.05). The barbell exercise reduces the participation of the serratus anterior in stabilizing the scapula (p < 0.05). Training exercises must therefore be chosen with knowledge of the specific muscle coordination induced by each. The counterweight exercise preserves the pectoralis major. The barbell exercise reduces participation of the serratus anterior. The dumbbells exercise may be useful to prepare the rotator cuff muscles carefully for use.
SIN3A, Generally Regarded as a Transcriptional Repressor, Is Required for Induction of Gene Transcription by the Aryl Hydrocarbon Receptor*

Background: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) activates transcription of CYP1A1. Results: Ectopic expression of SIN3A reverses the inhibitory effect of SIN3A siRNAs on CYP1A1 induction. TCDD stimulates SIN3A binding to the CYP1A1 enhancer and promoter. Conclusion: SIN3A coactivates TCDD induction of CYP1A1 transcription. Significance: The anomalous stimulatory effect of SIN3A on transcription is extended to a gene that is rapidly and dramatically induced. CYP1A1 bioactivates several procarcinogens and detoxifies several xenobiotic compounds. Transcription of CYP1A1 is highly induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) via the aryl hydrocarbon receptor. We recently described an RNAi high throughput screening performed in the Hepa-1 mouse hepatoma cell line, which revealed that SIN3A is necessary for the induction of CYP1A1-dependent ethoxyresorufin-o-deethylase (EROD) enzymatic activity by TCDD. In the current studies, we sought to provide insight into the role of SIN3A in this process, particularly because studies on SIN3A have usually focused on its repressive activity on transcription. We report that ectopic expression of human SIN3A in Hepa-1 cells enhanced EROD induction by TCDD and efficiently rescued TCDD induction of EROD activity in cells treated with an siRNA to mouse SIN3A, thus validating a role for SIN3A in CYP1A1 induction. We demonstrate that SIN3A is required for TCDD induction of the CYP1A1 protein in Hepa-1 cells but not for expression of the aryl hydrocarbon receptor protein. In addition, siRNAs for SIN3A decreased TCDD-mediated induction of CYP1A1 mRNA and EROD activity in human hepatoma cell line Hep3B. We establish that TCDD treatment of Hepa-1 cells rapidly increases the degree of SIN3A binding to both the proximal promoter and enhancer of the Cyp1a1 gene and demonstrate that increased binding to the promoter also occurs in human Hep3B, HepG2, and MCF-7 cells. These studies establish that SIN3A physically interacts with the CYP1A1 gene and extends the transcriptional role of SIN3A to a gene that is very rapidly and dramatically induced.
Closing sale of innovative treatment options for the treatment of diabetes and metabolic disorders?

Within the past decade, considerable numbers of drugs for the treatment of diabetes and metabolic disorders have either not reached the market, having been stopped late in development, or having been withdrawn after initial approval soon after market authorization due to serious safety concerns. Many formerly promising drug candidates with block buster potential in their respective therapeutic area have foundered, often with high financial losses for the developing drug company (Table 1). A critical look back over the past 10 years leads me sceptically to ask if we are currently experiencing a closing sale of innovative treatment options for treating diabetes and metabolic disorders?
Prognostic Marker for Liver Disease due to Alpha1-Antitrypsin Deficiency

Abstract Background: Only some Alpha1-antitrypsin deficiency (A1ATD) PiZZ patients develop liver cirrhosis and portal hypertension. Aim of the study was to investigate the course of liver disease associated with PiZZ A1ATD and to determine prognostic factors. Patients: We retrospectively reviewed the clinical and laboratory data of all PiZZ children up to 18 years of age admitted to our centre since 1978. 53 patients (age at first visit 2 days to 12 years) met our criteria. Methods: The children were divided into 2 groups: group 1 ‘bad prognosis’, meaning the patients which were on the waiting list for liver transplantation (LTx), had a liver transplantation or had died, and group 2 ‘good prognosis’, containing the patients they were living with their own liver. We analysed family history including smoking, gestational age, maternal age at delivery, date of birth, sex, neonatal history, breast-feeding, symptoms at presentation, clinical and laboratory data and date of LTx and/or death. Results: Various anamnesis parameters such as manifestation of neonatal cholestasis showed no prognostic significance. In contrast the laboratory parameters thrombocytes (p=0.008), bilirubin (p<0.001), prothrombin time (p<0.001), cholinesterase (p<0.001), gamma-GT (p=0.001) and GOT (p=0.002) showed a correlation with a liver transplantation and/or death. Conclusion: Prognosis is difficult to determine at an early stage of this disease, but various laboratory parameters can help to predict an outcome. Therefore a regular follow-up is necessary for the children.
ROBUST CONTROL OF AN AUTOMOTIVE ELECTROMECHANICAL BRAKE

Abstract This paper presents a robust H ∞ optimal control design for an automotive electromechanical brake (EMB). The design considers parametric uncertainty, unmodelled dynamics and the need for robust stability and performance. The capacity of a robust EMB control to manage uncertainty and performance is assessed and experimental and simulation results are presented. The tradeoffs involved in meeting a satisfactory performance specification in the presence of a reasonable set of actuator uncertainties are investigated and discussed. The robust control is benchmarked against a standard cascaded PI control for the EMB.
Sentiment Analysis for Effective Stock Market Prediction

The Stock market forecasters focus on developing a successful approach to predict stock prices. The vital idea to successful stock market prediction is not only achieving best results but also to minimize the inaccurate forecast of stock prices. This paper attempts to design and implement a predictive system for guiding stock market investment. The novelty of our approach is the combination of both sensex points and Really Simple Syndication (RSS) feeds for effective prediction. Our claim is that the sentiment analysis of RSS news feeds has an impact on stock market values. Hence RSS news feed data are collected along with the stock market investment data for a period of time. Using our algorithm for sentiment analysis, the correlation between the stock market values and sentiments in RSS news feeds are established. This trained model is used for prediction of stock market rates. In our experimental study the stock market prices and RSS news feeds are collected for the company ARBK from Amman Stock Exchange (ASE). Our experimental study has shown an improvement of 14.43% accuracy prediction, when compared with the standard algorithm of ID3, C4.5 and moving average stock level indicator.
Emergence of Sense-Making Behavior by the Stimulus Avoidance Principle: Experiments on a Robot Behavior Controlled by Cultured Neuronal Cells

Robot experiments using real cultured neuronal cells as controllers are a way to explore the idea of embodied cognition. Real cultured neuronal cells have innate plasticity, and a sensorimotor coupling is expected to develop a neural circuit. Previous studies have suggested that a dissociated neuronal culture has two properties: i) modifiability of connection between neurons by external stimuli and ii) stability of the connection without external stimuli. If cultured neuronal cells are embodied by coupling to an environment, they learn to avoid external stimulation. We call this mechanism a “learning by stimulation avoidance” principle. We try to demonstrate that adaptive behavior, like wall avoidance, can emerge spontaneously from embodied cultured neuronal cells. In this study, we developed a system in which a robot moves in a real environment and is controlled by cultured neuronal cells growing on a glass plate. We used a high-density complementary metal-oxide-semiconductor array to monitor the neural dynamics. We then conducted a robotic experiment using this platform. The results showed that wall-avoidance behavior by a robot can be enhanced spontaneously without giving any reward from the external environment.
Terminal Complement Components Mediate Release of von Willebrand Factor and Adhesion of Platelets in Arteries of Allografts

Background. Both humoral and cellular immune responses can cause arterial injury in organ transplants, but the manifestations of these different inflammatory mechanisms have not been dissected fully. The present study was designed to define the effects of the terminal complement components on arterial injury in vivo. Methods. The authors have developed congenic rat strains with a C6 deficiency. The absence of C6 terminates the cascade of complement after C5 cleavage and prevents the assembly of the membrane attack complex. Hearts were transplanted from PVG.1A (RT1a) rats to major histocompatibility complex-incompatible C6-deficient (C6−) or C6-sufficient (C6+) PVG.1U (RT1u) rats. Results. PVG.1A (C6−) cardiac grafts were rejected acutely (6–7 days) by untreated PVG.1U (C6+) recipients but survived significantly longer in PVG.1U (C6−) recipients (8 to >30 days). Arteries of cardiac allografts in C6+ recipients demonstrated extensive endothelial injury evidenced by release of von Willebrand factor (vWF) and accompanied by platelet aggregation. In contrast, vWF was retained in Weibel-Palade storage granules of arterial endothelial cells in cardiac allografts that were rejected by C6− recipients. In the absence of C6, intimal alterations were limited to lifting of endothelial cells from supporting stroma by infiltrating mononuclear cells, duplicating the clinical lesion described as endotheliitis or intimal arteritis. Delaying graft rejection with a short course of cyclosporine did not decrease vWF release and platelet aggregation in PVG.1U (C6+) recipients. Conclusions. Mononuclear cell infiltration of the arterial intima occurs in the absence of C6, but C6 deficiency limits the release of vWF from arterial endothelial cells.
The spectrum of benign and malignant etiologies of cervical node calcification.

OBJECTIVE The purpose of this study was to determine if the presence and pattern of lymph node calcification can be used to make a limited differential diagnosis and differentiate benign from malignant disease. MATERIALS AND METHODS Two radiologists reviewed each of 2300 neck CT scans obtained at our institution between January 1996 and July 1998 for the presence of nodal calcifications. The scans were obtained as 3-mm contiguous axial sections, and most were obtained with IV contrast material. Twenty-six scans revealed nodal calcification, which was classified as being within the node itself or along the periphery of the node. The diagnosis was established from surgical specimens for 20 patients and from CT-guided thin-needle biopsy for four patients. For two patients, the diagnosis was inferred from a previously well-documented case of the disease. RESULTS Of the 2300 scans, 26 (1%) showed nodal calcification. Of these 26, eight (31%) were from patients with benign disease; six (23%) from patients with treated diseases, including four lymphomas and one infection; and 12 (46%) from patients with malignancies, including nine cases of head and neck primary tumors and three cases of metastatic adenocarcinoma from breast and lung primary tumors. CONCLUSION Cervical node calcification is rare. On the basis of our limited number of cases, nodal calcification, regardless of its location within the node, is not a reliable predictor of either benign or malignant disease. However, nodal calcification does suggest a limited differential diagnosis that most commonly includes tuberculosis, treated lymphoma, and metastatic thyroid carcinoma, adenocarcinoma, or squamous carcinoma.
Web Indicators for Research Evaluation: A Practical Guide

Abstract In recent years there has been an increasing demand for research evaluation within universities and other research-based organisations. In parallel, there has been an increasing recognition that traditional citation-based indicators are not able to reflect the societal impacts of research and are slow to appear. This has led to the creation of new indicators for different types of research impact as well as timelier indicators, mainly derived from the Web. These indicators have been called altmetrics, webometrics or just web metrics. This book describes and evaluates a range of web indicators for aspects of societal or scholarly impact, discusses the theory and practice of using and evaluating web indicators for research assessment and outlines practical strategies for obtaining many web indicators. In addition to describing impact indicators for traditional scholarly outputs, such as journal articles and monographs, it also covers indicators for videos, datasets, software and other non-standard .
Generation of hyper climate modes

It is shown that some important aspects of the space‐time structure of multidecadal sea surface temperature (SST) variability can be explained by local air‐sea interactions. A concept for “Global Hyper Climate Modes” is formulated: surface heat flux variability associated with regional atmospheric variability patterns is integrated by the large heat capacity of the extra‐tropical oceans, leading to a continuous increase of SST variance towards longer timescales. Atmospheric teleconnections spread the extra‐tropical signal to the tropical regions. Once SST anomalies have developed in the Tropics, global atmospheric teleconnections spread the signal around the world creating a global hyper climate mode. A simple model suggests that hyper climate modes can vary on timescales longer than 1,000 years. Ocean dynamics may amplify theses modes and influence the regional expression of the variability, but are not at the heart of the mechanism which produces the hyper modes.
Associations between strain in domestic work and self-rated health: A study of employed women in Sweden

Aim: The aim of this study was to analyse the association between strain in domestic work and self-rated health among employed women in Sweden, using two different methods of measuring strain in domestic work. Methods: Questionnaire data were collected on health and living conditions in paid and unpaid work for employed women (n=1,417), aged 17—64 years. ``Domestic job strain'' was an application of the demand—control model developed by Karasek and Theorell, and ``Domestic work equity and marital satisfaction'' was measured by questions on the division of and responsibility for domestic work and relationship with spouse/cohabiter. Self-rated health was measured using the SF-36 Health Survey. Associations were analysed by bivariate and multivariate linear regression analyses, and reported as standardized regression coefficients. Results: Higher strain in domestic work was associated with lower self-rated health, also after controlling for potential confounders and according to both strain measures. ``Domestic work equity and marital satisfaction'' showed for example negative associations with mental health β -0.211 (p<0.001), vitality β -0.195 (p<0.001), social function -0.132 (p<0.01) and physical role β -0.115 (p<0.01). The highest associations between ``Domestic job strain'' and SF-36 were found for vitality β -0.156 (p<0.001), mental health β -0.123 (p<0.001). Conclusions: Strain in domestic work, including perceived inequity in the relationship and lack of a satisfactory relationship with a spouse/ cohabiter, was associated with lower self-rated health in this cross-sectional study. Future research needs to address the specific importance of strain in domestic work as a contributory factor to women's ill-health.
Long-term results after surgical reconstruction for renal artery fibromuscular dysplasia.

OBJECTIVES To study the initial and long-term results of surgery for renal artery fibromuscular dysplasia (RFMD). PATIENTS AND METHODS All patients undergoing renal artery reconstruction (RAR) performed for RFMD between January 1980 and December 1997, were studied. The preprocedural and postprocedural clinical records of 101 patients (80 women, 21 men; mean age at surgery 43 years) were retrospectively reviewed. All surviving patients were invited for clinical reexamination and colour-coded duplex-ultrasound of the renal arteries (RA). RESULTS Initial technical success was achieved in 83 of 93 patients (89%), in whom postoperative angiography (90) or renal scintigraphy (three) were performed for assessment of RAR. Early occlusion (four) or stenosis (one) demanded reoperation in five patients (5%). The 30-day mortality and morbidity were 2% and 12% for the entire group. Primary patency rate was 74% at 5 years. Fifteen patients had to be reoperated for restenosis after a mean time of 33 months, resulting in a secondary patency rate of 85% after 5 years. In 61 patients with patent RAR at the time of re-examination, arterial hypertension was cured only in 22 (36%) and improvement in 19 (31%). CONCLUSION Vascular surgery for RFMD yields good long-term results as to kidney perfusion and function. Surveillance of RAR-patency by means of ultrasound examination is mandatory in case of recurrence of arterial hypertension or deterioration. Rates of cure of hypertension are disappointing.
Cervical Intraepithelial Neoplasia in Immunosuppressed Women after Renal Transplantation

All 26 immunosuppressed renal transplant females attending the Renal Unit at the Western Infirmary, Glasgow were screened by cervical cytology and colposcopy for evidence of cervical neoplasia. Five patients (19.2%) were discovered to have cervical intraepithelial neoplasia, confirming the expected increase in this ‘at risk’ group. Regular cervical screening in these immunosuppressed women is recommended strongly.
The Relationship between Mid-face Fractures and Brain Injuries

Statement of Problem: Although advances in technology have led to improvements in man’s life in different aspects, statistics show that the incidence of fractures is increasing in different regions of the body. Recent studies showthat show that midface fractures are strongly associated with patient's death. The exact relationship between different types of facial fractures and brain injuries is still controversial. Purpose: To evaluate individuals with midface fractures from different causes and determine if there is any relationship between various midface fractures and brain injuries. Materials and Me thods: In t his descriptive cross-sectional retrospective study , w e assessed the hospital charts of all the patients with midface fractures at the trauma center of Poursina hospital. The complete medical record of each patient was reviewed . T he etiologic and demographic data, the type of midface fracture and brain injury, and Glasgow coma scale (GCS) were assessed . The data were analyzed by, the C hi-square, and the Fisher’s exact test s . The statistical package SPSS was used for all the analyses. Results: O f all the patients 47% had brain injury. The Important significant results correlations were as follows: Le Fort II with Subdural Hematoma ( p =0.001), Brain Contusion ( p =0.049), Intracranial Hemorrhage ( p =0.001), Le Fort III with Subdural He - matoma ( p =0.001), Brain Contusion ( p =0.0001), n asal o rbital e thmoid fractures with s ubdural h ematoma ( p =0.0001), Epidural Hematoma ( p =0.003), f rontal f racture with s ubdural h ematoma ( p =0.0001) , Intracranial Hemorrhage ( p =0.024) . Zygomatic complex fracture with Brain Con - tusion ( p =0.009). Nasal fracture correlated with Subdural Hematoma ( p =0.01) and Brain Contusion ( p =0.0001). The zygomatic complex fracture was the most prevalent fracture. Conclusion: Different midface fracture patterns have the risk of brain injury simultaneously. So midface fractures need more attention. According to the results, more attention is needed to be paid to driving rules specially the use of helmet and seat belt.