Miracle-dz/UniFAR-FTUs huggingface dataset:
Postdischarge Opioid Use After Cesarean Delivery.

OBJECTIVE To characterize postdischarge opioid use and examine factors associated with variation in opioid prescribing and consumption. METHODS We conducted a prospective observational cohort study by recruiting all women undergoing cesarean delivery during an 8-week period, excluding those with major postoperative morbidities or chronic opioid use. Starting on postoperative day 14, women were queried weekly regarding number of opioid pills used, amount remaining, and their pain experience until they had stopped opioid medication. Demographic and delivery information and in-hospital opioid use were recorded. The state Substance Monitoring Program was accessed to ascertain prescription-filling details. Morphine milligram equivalents were calculated to perform opioid use comparisons. Women in the highest quartile of opioid use (top opioid quartile use) were compared with those in the lowest three quartiles (average opioid use). RESULTS Of 251 eligible patients, 246 (98%) agreed to participate. Complete follow-up data were available for 179 (71% of eligible). Most women (83%) used opioids after discharge for a median of 8 days (interquartile range 6-13 days). Of women who filled their prescriptions (165 [92%]), 75% had unused tablets (median per person 75 morphine milligram equivalents, interquartile range 0-187, maximum 630) and the majority (63%) stored tablets in an unlocked location. This amounts to an equivalent of 2,540 unused 5-mg oxycodone tablets over our study period. Women who used all prescribed opioids (n=40 [22%]) were more likely to report that they received too few tablets than women who used some (n=109 [61%]) or none (n=30 [17%]) of the prescribed opioids (33% compared with 4% compared with 5%, P<.001). The top quartile was more likely to be smokers than average users and consumed more opioid morphine milligram equivalents per hour of inpatient stay than average opioid users (1.6, interquartile range 1.1-2.3 compared with 1.0, interquartile range 0.5-1.4, P<.001). CONCLUSION Most women-especially those with normal in-hospital opioid use-are prescribed opioids in excess of the amount needed.
“Coming Out” Stories of Gay and Lesbian Young Adults

Gay and lesbian young adults (N = 53) were interviewed about coming out to their parents. Analyses of memory content were conducted. Hypotheses related to disclosure were largely supported. Participants typically first disclosed their sexual orientation to a friend. More participants came out to their mother than their father. When disclosure was made to both parents, mothers were told prior to fathers. Mothers were often told using direct methods, whereas fathers were typically informed using indirect methods. Mothers tended to inquire about their sons' sexuality; mothers inquired less with daughters. Findings are discussed in relation to autobiographical memory, sexuality, and clinical literatures.
Mental Health Resources for LGBT Collegians: A Content Analysis of College Counseling Center Web Sites

This study content analyzed a randomly selected stratified national sample of 203 four-year United States colleges' counseling center Web sites to assess the degree to which such sites feature information and reference services for lesbian, gay, bisexual, and transgender (LGBT) collegians. Results revealed that LGBT-targeted communications were infrequent. For instance, fewer than one third of counseling center Web sites described individual counseling opportunities for LGBT students, fewer than 11% mentioned group counseling opportunities, and fewer than 6% offered a university crafted pamphlet with information about LGBT issues and resources. Findings are interpreted within the context of prior LGBT student health research.
Evolutionary formation of new protein folds is linked to metallic cofactor recruitment

To explore whether the generation of new protein folds could be linked to metallic cofactor recruitment, we identified the oldest examples of folds for manganese, iron, zinc, and copper proteins by analyzing their fold‐domain mapping patterns. We discovered that the generation of these folds was tightly coupled to corresponding metals. We found that the emerging order for these folds, i.e., manganese and iron protein folds appeared earlier than zinc and copper counterparts, coincides with the putative bioavailability of the corresponding metals in the ancient anoxic ocean. Therefore, we conclude that metallic cofactors, like organic cofactors, play an evolutionary role in the formation of new protein folds. This link could be explained by the emergence of protein structures with novel folds that could fulfill the new protein functions introduced by the metallic cofactors. These findings not only have important implications for understanding the evolutionary mechanisms of protein architectures, but also provide a further interpretation for the evolutionary story of superoxide dismutases.
Whose Crazy Investment in Sex?

By probing the processes of exclusion of transsexuals from the political sphere, this article offers contributions to social and political theory through an examination of the processes of exclusion from the category “human. ” This article considers how the erasure of investment in their own embodied sex constructs a platform from which to blame others for sex/gender variance, as well as to justify that blaming. Bringing together Giorgio Agamben, Georges Bataille, Judith Butler, and Nikolas Rose with transphobia, medicalization in psychiatry, law, and ethopolitics, this article questions whose investment in sexed embodiment counts and why that investment might be seen as “crazy. ”
Mitosis in diatoms: rediscovering an old model for cell division

Diatoms are important protists that generate one fifth of the oxygen produced annually on earth. These aquatic organisms likely derived from a secondary endosymbiosis event, and they display peculiar genomic and structural features that reflect their chimeric origin. Diatoms were one of the first models of cell division and these early studies revealed a range of interesting features including a unique acentriolar microtubule‐organising centre. Unfortunately, almost nothing is known at the molecular level, in contrast to the advances in other experimental organisms. Recently the full genome sequences of two diatoms have been annotated and molecular tools have been developed. These resources offer new possibilities to re‐investigate the mechanisms of cell division in diatoms by recruiting information from more intensively studied organisms. A renaissance of the topic is further justified by the current interest in diatoms as a source of biofuels and for understanding massive diatom proliferation events in response to environmental stimuli.
The Language of (In)Visibility: Using In-Between Spaces as a Vehicle for Empowerment in the Family

Drawing on 40 in-depth interviews with sexually nonconforming Latinas, this work looks at how these women negotiate family and achieve empowerment both through visibility and invisibility. This work explores the experiences of Latinas who verbally articulated their sexual nonconformity to their families as well as those who chose to maintain their relationships tacit. I offer that study participants found empowerment and agency not only through verbal articulation but also through tacit relationships and that sexually nonconforming Latinas inhabited an “in-between space” with their families that gave them the flexibility to pursue or not pursue visibility as they desired.
Characterizing the Functional Decline of Older Women With Incident Urinary Incontinence.

OBJECTIVE To characterize change in physical performance and differential prevalence of low skeletal muscle mass and strength (sarcopenia) and lower 25-hydroxyvitamin D concentrations among older women who developed urinary incontinence (UI) symptoms. METHODS This is a secondary analysis of the Health, Aging, and Body Composition Study. Urinary incontinence symptoms were assessed using validated questions. The Short Physical Performance Battery measured physical performance. Sarcopenia, defined by low muscle mass and strength, was determined using validated cutoffs for gait speed, grip strength, and appendicular skeletal muscle mass. All parameters were evaluated at baseline and year 4. Serum 25-hydroxyvitamin D concentrations were assessed at year 2. The primary outcome was change in Short Physical Performance Battery total scores. Sarcopenia and lower serum 25-hydroxyvitamin D concentrations have been independently associated with poor physical performance and UI and were therefore included as secondary outcomes. Univariate and multivariate analyses were used to characterize the associations of change in physical performance from baseline to year 4, incidence of sarcopenia, and lower serum 25-hydroxyvitamin D on the development of UI symptoms. RESULTS Of the 1,583 women enrolled, 910 were excluded (730 had baseline UI; 180 with missing data). Six hundred seventy-three women were continent at baseline; 223 (33%) developed UI symptoms at year 4. SPPB total scores significantly declined in women with UI versus continent women (mean difference continent-incident UI 0.32, 95% CI 0.04-0.60, P=.02). Of subscale measures, standing balance showed the greatest decline at 0.20 (0.05-0.36; continent-incident UI, respectively; P=.009). Sarcopenia developed at a higher rate with incident UI (adjusted odds ratio [OR] 1.7, 95% CI 1.0-2.9). Low 25-hydroxyvitamin D was not associated with incident UI (adjusted OR 1.1, 95% CI 0.7-1.6 and 1.1, 95% CI 0.7-1.6 for deficient or insufficient versus sufficient status, respectively). CONCLUSION We observed a significant decline in standing balance among older women who developed UI symptoms. This decline may be associated with coinciding development of sarcopenia.
From Gender Identity Disorder to Gender Identity Creativity: True Gender Self Child Therapy

True gender self child therapy is based on the premise of gender as a web that weaves together nature, nurture, and culture and allows for a myriad of healthy gender outcomes. This article presents concepts of true gender self, false gender self, and gender creativity as they operationalize in clinical work with children who need therapeutic supports to establish an authentic gender self while developing strategies for negotiating an environment resistant to that self. Categories of gender nonconforming children are outlined and excerpts of a treatment of a young transgender child are presented to illustrate true gender self child therapy.
Portuguese Adolescents' Attitudes Toward Sexual Minorities: Transphobia, Homophobia, and Gender Role Beliefs

Research has shown that negative attitudes toward lesbians and gay men are common and widespread in Western societies. However, few studies have addressed attitudes toward transgender individuals. In addition, although research has shown that homophobic harassment and bullying is highly common among adolescents, little is known about adolescent's attitudes toward sexual minorities. This study aimed to fill these gaps in knowledge, by investigating adolescents' attitudes toward transgender individuals and possible attitudinal correlates of those attitudes. Participants (N = 188; 62 males and 126 females) were recruited in high schools in Lisbon, Portugal. Age ranged from 15 to 19 years (M = 17; SD = .96). Participants completed a questionnaire booklet measuring attitudes toward transgender individuals, lesbians, and gay men, and gender role beliefs. Results revealed that attitudes toward transgender individuals were significantly correlated with all attitude measures. Specifically, it was revealed that those participants who endorsed negative attitudes toward transgender individuals were also endorsing of negative attitudes toward lesbians and gay men and tended to adhere to traditional gender roles. A significant gender effect was found with males being more negative toward sexual minorities than females, but these negative attitudes were more extreme toward gay men than toward lesbian women. Implications of these findings are discussed.
Mental Health Characteristics of Sexual Minority Veterans

This study examines the mental health characteristics of sexual minority (lesbian, gay, and bisexual, or LGB) veterans, compared these characteristics to those of an existing Veterans Affairs (VA) sample, and examined the relationship between mental health and anxiety around concealment of LGB identity while in the military. Data regarding LGB veterans’ (n = 409) military experiences and current mental health were collected via an online survey; comparison data (n = 15,000) were retrieved from a VA data warehouse. LGB veterans were more likely to screen positive for posttraumatic stress disorder (PTSD), depression, and alcohol problems than the comparison sample. Anxiety around concealment of one's sexual orientation while in the service was related to current depression and PTSD symptoms.
Etiology and Attitudes: Beliefs About the Origins of Homosexuality and Their Implications for Public Policy

Using survey data from the 2008 election cycle, this article updates and extends analysis of public attitudes regarding various aspects of homosexuality. Continued expansion of public belief in a biological root to homosexuality is found, and variations in such opinions are explored. Public attitudes toward the emerging issue of gay adoption is also examined, finding both similarities with and important differences from attitudes toward same-sex civil unions, although both are profoundly influenced by underlying attitudes regarding the causes of homosexuality.
Undernutrition among children in South and South‐East Asia

Undernutrition remains a major public health problem among children living in Asia. Although the burden is maximal among poorer, rural and Indigenous communities, the problem affects the majority in many Asian countries, especially in South Asia. In order to prevent the pervasive consequences of undernutrition, strategies that address this burden are required. Successful implementation of strategies may be limited by the complex aetiology of undernutrition, including the political setting. Rising food insecurity because of climate change, land use for biofuel production and the recent global financial crisis threaten to exacerbate childhood malnutrition. In this review, we describe the burden of undernutrition among Asian children and discuss contributing factors and potential solutions.
Intimate Partner Violence, Minority Stress, and Sexual Risk-Taking Among U.S. Men Who Have Sex With Men

This article examines the prevalence of intimate partner violence (IPV) among a national sample of Internet-recruited U.S. men who have sex with men (MSM) (n = 1,575), and associations between reporting of IPV, minority stress, and sexual risk-taking. Five outcomes are examined: experiences of physical and sexual violence, perpetration of physical and sexual violence, and unprotected anal intercourse (UAI) at last sexual encounter. MSM who reported experiencing more homophobic discrimination and internalized homophobia were more likely to report experiences of IPV. The results point to the need for prevention messages to address the external and internal stressors that influence both violence and sexual risk among MSM.
Outcome After Anterior Vaginal Prolapse Repair: A Randomized Controlled Trial

OBJECTIVES: To report 1-year outcomes of a randomized controlled trial comparing polypropylene mesh–reinforced anterior vaginal prolapse repair with anterior colporrhaphy. METHODS: Seventy-six patients with stage II or greater anterior vaginal prolapse were randomly assigned to either colporrhaphy or polypropylene mesh repair. The primary outcome was recurrent stage II anterior vaginal prolapse, and secondary outcomes were effects on quality of life and sexual symptom scores, operative time, blood loss, length of hospitalization, and adverse events. RESULTS: Thirty-eight women had anterior colporrhaphy, and 37 had polypropylene mesh repair. One patient allocated to mesh repair withdrew from the study before surgery. Clinical and demographic data did not differ significantly between the two treatment groups. One year after surgery, optimal and satisfactory anterior vaginal support were obtained in 21 of 38 (55%) of the colporrhaphy group and 33 of 38 (87%) of the mesh group (P=.005). Patients in both groups reported less bother after surgery in both prolapse and urinary symptoms. The rates of de novo dyspareunia were 4 of 26 (16%) and 2 of 23 (9%) in the colporrhaphy and mesh groups, respectively. Two of 37 (5%) patients had vaginal mesh extrusion. Nine anterior colporrhaphy patients would have to have recurrent anterior vaginal prolapse to prevent one vaginal mesh extrusion. Neither serious adverse events nor deaths occurred in either group. CONCLUSION: Anterior vaginal prolapse repair with polypropylene mesh reinforcement offers lower anatomic recurrence than anterior colporrhaphy at one year. However, quality of life and sexual symptoms scores improved in both groups. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, www.clinicaltrials. gov, NCT00535301 LEVEL OF EVIDENCE: I
Homosexuality in Turkey: Strategies for Managing Heterosexism

The goal of this study was to identify the strategies used by young homosexuals to manage their sexual minority status in Turkey. In-depth interviews were conducted with 15 self-identified homosexual university students. The data on the strategies employed by homosexuals suggested a categorization of these strategies into four interrelated areas: strategies employed in the process of self-acceptance; strategies to manage sexual stigma and prejudice; strategies specific to the coming-out process; and the strategies used while openly expressing their sexual identities.
Relation Between Streptococcus mutans and Smooth Surface Caries in the Deciduous Dentition

Streptococci with a caries-inducing potential of the type described in Streptococcus mutans have been found with greater frequency in the dental plaque of populations with a high prevalence of dental caries than in populations with a low prevalence (B. KRASSE, H. V. JORDAN, S. EDWARDSSON, I. SVENSSON, and L. TRELL, Arch Oral Biol 13:911-918, 1968; H. V. JORDAN, H. R. ENGLANDER, and S. LIM, JADA 78:1331-1335, 1969; J. D. DE STOPPELAAR, J. VAN HOUTE, and 0. BACKER-DIRKS, Caries Res 3:190-199, 1969). The following data are from a survey of the presence of S muitans in plaque and dental caries experience on smooth surfaces of the deciduous teeth of a group of 93 Caucasian pre-school children, aged 19 to 54 months, who were dependents of US Coast Guard personnel living on Governors Island, NY. The children had been exposed to fluoridated water either partially or continuously from birth. Ages were computed to the nearest birthday and the children were distributed uniformly over the age range; about 42% were females. Each child was considered to have experienced dental caries that had been initiated on a smooth surface, if he showed one tooth or more with a discrete lesion or a restoration on any smooth area of the facial, lingual, or proximal surfaces. The mean age of the 15 children with such caries experience was 45 months, ranging from 37 to 54. None of the children had any molars missing. Bitewing radiographs for diagnosis were used for only the older children whose proximal surfaces could not be clearly observed clinically. To identify children harboring S mutans, plaque samples were collected from all accessible tooth surfaces with a cleoid carver and were cultured on Mitis-Salivarius agar. Isolates were identified by methods described previously
Long non-coding RNA modifies chromatin

Common themes are emerging in the molecular mechanisms of long non‐coding RNA‐mediated gene repression. Long non‐coding RNAs (lncRNAs) participate in targeted gene silencing through chromatin remodelling, nuclear reorganisation, formation of a silencing domain and precise control over the entry of genes into silent compartments. The similarities suggest that these are fundamental processes of transcription regulation governed by lncRNAs. These findings have paved the way for analogous investigations on other lncRNAs and chromatin remodelling enzymes. Here we discuss these common mechanisms and provide our view on other molecules that warrant similar investigations. We also present our concepts on the possible mechanisms that may facilitate the exit of genes from the silencing domains and their potential therapeutic applications. Finally, we point to future areas of research and put forward our recommendations for improvements in resources and applications of existing technologies towards targeted outcomes in this active area of research.
Changing Attitudes Through Social Influence: Does Social Distance Matter?

ABSTRACT To test the effects of social influence and social distance on attitudes, we assessed judgments of gay and lesbian targets in various contexts over three studies (n = 814, 51% female). We compared the impact of a derogatory message to a relatively favorable message ostensibly written by another participant. Participants were robustly moved by the feedback; social influence was a significant predictor in final evaluations of the target, as was social distance. Discrimination against gay men and lesbian women appears not to be a fixed behavior; seemingly anyone can be persuaded to discriminate or not to discriminate by mere peer suggestion.
How Like Perceives Like: Gay People on “Gaydar”

When lacking explicit knowledge of someone’s sexual orientation, gay people commonly assess the likelihood that another is gay using their “gaydar. ” The term gaydar is a playful mix of the word gay with radar, suggesting that one can sense, intuit, or perceive some set of characteristics in another that signal a shared minority status. While commonly mentioned, the exact criteria a gay person uses when employing their gaydar are little discussed. Drawing methodologically on a series of five focus groups of self-identified lesbians and gay men, this study explores the physical, visual, energetic, and conversational cues gay people consider when they employ the trope of gaydar. Specifically, interview subjects most often described their gaydar as triggered by the following elements: physical presentation, including mannerisms, dress, and voice; interactions, especially eye contact; a presence or absence of certain conversational social norms; and, intangibly, as a kind of energetic exchange.
Persecution Experiences and Mental Health of LGBT Asylum Seekers

ABSTRACT Asylum seekers are a unique population, particularly those who have endured persecution for their sexual orientation or gender identity. Little data exist about the specific experiences and needs of asylum seekers persecuted due to lesbian, gay, bisexual, or transgender (LGBT) identity. Quantitative data were gathered regarding demographics, persecution histories, and mental health of 61 clients from a torture survivors program in New York City who reported persecution due to LGBT identity. Thirty-five clients persecuted due to their LGBT identity were matched by country of origin and sex with clients persecuted for other reasons to explore how persecution and symptoms may differ for LGBT clients. LGBT asylum seekers have a higher incidence of sexual violence, persecution occurring during childhood, persecution by family members, and suicidal ideation. Understanding the type of persecution experiences and how these influence mental health outcomes is an essential step toward designing and delivering effective treatments.