Miracle-dz/UniFAR-FTUs huggingface dataset:
Needle-Free Skin Patch Vaccination Method for Anthrax

ABSTRACT Three immunizations of mice with recombinant protective antigen (rPA) by transcutaneous immunization (TCI) induced long-term neutralizing antibody titers that were superior to those obtained with aluminum-adsorbed rPA. In addition, rPA alone exhibited adjuvant activity for TCI. Forty-six weeks after completion of TCI, 100% protection was observed against lethal anthrax challenge.
Capture of the Sun's Oort Cloud from Stars in Its Birth Cluster

Out of the Oort Cloud Long-period comets originate from the Oort cloud, a vast reservoir of icy bodies that surrounds the solar system. These bodies are thought to be remnants from the formation of the solar system. But did they all form in the Sun's protoplanetary disk, or could they have been generated in the protoplanetary disks of other stars in the cluster where the Sun probably formed? Levison et al. (p. 187, published online 10 June) used detailed numerical simulations to investigate what fraction of comets might transfer from the outer reaches of one stellar system to another. The simulations suggest that a substantial number of comets can be captured through this mechanism, which may explain why the number of bodies in the Oort cloud is larger than models predict. Some Oort cloud comets may have originated in the protoplanetary disk of stars other than the Sun. Oort cloud comets are currently believed to have formed in the Sun's protoplanetary disk and to have been ejected to large heliocentric orbits by the giant planets. Detailed models of this process fail to reproduce all of the available observational constraints, however. In particular, the Oort cloud appears to be substantially more populous than the models predict. Here we present numerical simulations that show that the Sun captured comets from other stars while it was in its birth cluster. Our results imply that a substantial fraction of the Oort cloud comets, perhaps exceeding 90%, are from the protoplanetary disks of other stars.
Fibulin 5 Forms a Compact Dimer in Physiological Solutions*

Fibulin 5 is a 52-kDa calcium-binding epidermal growth factor (cbEGF)-rich extracellular matrix protein that is essential for the formation of elastic tissues. Missense mutations in fibulin 5 cause the elastin disorder cutis laxa and have been associated with age-related macular degeneration, a leading cause of blindness. We investigated the structure, hydrodynamics, and oligomerization of fibulin 5 using small angle x-ray scattering, EM, light scattering, circular dichroism, and sedimentation. Compact structures for the monomer were determined by small angle x-ray scattering and EM, and are supported by close agreement between the theoretical sedimentation of the structures and the experimental sedimentation of the monomer in solution. EM showed that monomers associate around a central cavity to form a dimer. Light scattering and equilibrium sedimentation demonstrated that the equilibrium between the monomer and the dimer is dependent upon NaCl and Ca2+ concentrations and that the dimer is dominant under physiological conditions. The dimerization of fragments containing just the cbEGF domains suggests that intermolecular interactions between cbEGFs cause dimerization of fibulin 5. It is possible that fibulin 5 functions as a dimer during elastinogenesis or that dimerization may provide a method for limiting interactions with binding partners such as tropoelastin.
Presence of Friday Effect in the Indian Stock Market

Identification of the day of the week effect in the capital market can be of immense help for an investor to reap handsomely from investment in the stock market. Various studies undertaken on capital markets of the developed countries have identified ‘the Monday effect’. “Is there any such effect in the Indian capital market? ” To find an answer to this question is the motivating factor for our study. This study has been done by considering two different indices and is divided into three sections. Section I deals with the literature pertaining to earlier studies undertaken by different researchers. Section II discusses the methodology of our study and section III elaborately provides the results obtained. Use of vital non parametric test and Dunn's multiple pair comparison test infer the presence of seasonal effect, i.e., returns on Friday are the highest in the Indian capital market.
Electroantennogram and behavioural responses of the malaria vector Anopheles gambiae to human‐specific sweat components

Abstract. Afrotropical malaria vectors of the Anopheles gambiae complex (Diptera: Culicidae), particularly An. gambiae sensu stricto, are attracted mainly to human hosts. A major source of human volatile emissions is sweat, from which key human‐specific components are the carboxylic acids (E)‐ and (Z)‐3‐methyl‐2‐hexenoic acid and 7‐octenoic acid. Electrophysiological studies on the antennae of An. gambiae s.s. showed selective sensitivity to these compounds, with a threshold at 10−6 g comparable to that of known olfactory stimulants 1‐octen‐3‐ol, p‐cresol, isovaleric acid, and lower than threshold sensitivity to l‐lactic acid and the synthetic mosquito repellent N,N‐diethyltoluamide (DEET). A combination of the acids released at concentrations > 10−5 g in wind tunnel bioassays significantly reduced the response to CO2, the major attractant released by human hosts, for strains of An. gambiae s.s. originating from East and West Africa.
Genomic signatures of local adaptation in the Drosophila immune response

ABSTRACT As environments and pathogen landscapes shift, host defenses must evolve to remain effective. Due to this selection pressure, among-species comparisons of genetic sequence data often find immune genes to be among the fastest evolving genes across the genome. The full extent and nature of these immune adaptations, however, remain largely unexplored. In a recent study, we analyzed patterns of selection within distinct components of the Drosophila melanogaster immune pathway. While we found evidence of positive selection within some immune processes, immune genes were not universally characterized by signatures of strong selection. On the contrary, we even found that some immune functions show greater than expected constraint. Overall these results highlight 2 major factors that appear to play an outsize role in determining a gene's evolutionary rate: the type of pathogen the gene targets and the gene's position within the immune network. These results join a growing body of literature that highlight the complexity of immune adaptation. Rather than there being uniformly strong selection across all immune genes, a combination of pathogen-specificity and host genetic constraints appear to play key roles in determining each immune gene's individual evolutionary trajectory.
Foreign Direct Investment and Investor Sentiment: A Causal Relationship

Abstract Past studies investigated a number of fundamental variables influencing FDI in various countries. This study offers extensive evidence on the impact of investor sentiment on net FDI flows in Malaysia. Using a vector error correction framework, this study analyzed the net FDI flows in Malaysia for 56 quarterly observations between 1998 and 2011, and reported a strong positive connection between investor sentiment index and FDI flows in the presence of other macroeconomic variables in the long- and short-run. Other important factors deciding FDI in Malaysia are real GDP, interest rate and currency value. FDI exhibited a bi-directional Granger causality with investor sentiment and gross domestic product. FDI is also Granger caused by interest rate. Decomposing the sentiment index to two sub-indexes, we find that the attitude dimension of the index hold greater influence on FDI than the market trading dimensions although both are significant. The study concludes that expectation around financial market, expected economic condition of the country and the region (i. e. ASEAN), and interest rates are important determinants of FDI in Malaysia. It is one of the findings of this study that FDI cannot be attracted simply based on economic stability of the country; rather a conducive regional atmosphere is indeed necessary. Consequently, our findings suggest that rather than implementing policies to improve macroeconomic conditions, governments should attempt to improve the perception and outlook of Malaysia to foreign investors in order to increase FDI flows into the country. Investing in bilateral (and/or multilateral) relationships can be one of the steps to create a positive impression for the region to attract more foreign companies.
Different p53 mutation patterns in colorectal tumors from smokers and nonsmokers

Epidemiological studies consistently find associations between colorectal cancer and cigarette smoking; however, there are little molecular data supporting the association. To examine the relationship between cigarette smoking and colorectal cancer, we compared p53 mutation patterns in colorectal tumors from smokers and nonsmokers. In this study, 153 tumor tissues from colorectal cancer patients, including 63 smokers and 90 nonsmokers, were examined for p53 mutation and p53 protein expression by direct sequencing and immunohistochemistry (IHC), respectively. p53 mutations were detected in 77 of 153 (50.3%) colorectal tumors, and no difference was observed in the p53 mutation frequencies in tumors from smokers and nonsmokers (33 of 63, 50.8% for smokers vs. 44 of 90, 48.9% for nonsmokers, P = 0.743). IHC showed that p53‐immunoreactive tumors were positively correlated with p53‐mutated tumors (P < 0.0001). G:C→A:T transition and G:C→T:A transversion were the predominant types of mutations detected in the tumor p53 genes. G:C→A:T mutation was relatively more common in nonsmokers than in smokers (93.5% for nonsmokers vs. 77.3% for smokers), although this difference was not significant. The frequency of deletion mutation in smoker tumors, however, was significantly higher than that in nonsmoker tumors (7 of 33, 21.2% for smokers vs. 1 of 44, 2.3% for nonsmokers, P = 0.01). Although there were only a few cases of p53 deletion mutation in this study, the observation of a higher frequency of p53 deletion mutation in smoker tumors supports the association between cigarette smoking and the development of colorectal cancer. Environ. Mol. Mutagen. , 2006. © 2006 Wiley‐Liss, Inc.
Asymmetric Tactile Foot Stimulation: How Postural Studies May Suggest New Views of Hypnotizability

Abstract Earlier studies have shown hypnotizability-related postural effects of visual suppression and of leg and neck proprioceptive alteration. This study completes this investigation by demonstrating the postural effects of asymmetric tactile foot stimulation in standing participants with different hypnotizability scores. During this stimulation, body sway changed in medium-to-high more than in low-to-medium hypnotizable participants. Findings support the view that high hypnotizability is associated with higher vulnerability of posture to sensory alteration; together with earlier results, they suggest a role of the cerebellum in the observed hypnotizability-related differences and prompt investigation of cerebral structures and factors potentially responsible for both the cognitive and physiological aspects of hypnotizability.
Urban water: a political-ecology perspective

This paper explores a political-ecological perspective on the relationship between urbanization, sustainability, and the production and distribution of urban water. The focus is on the interrelationship between social, economic, political, and environmental processes as they are expressed in the way urban water systems are organized. The first part summarizes the main components of a political-ecological perspective, with particular reference to questions of urban socio-environmental sustainability. In the second part, the critical moments with respect to the contemporary organization, management, and dynamics of the urban water cycle are explored, with particular reference to the findings of five case studies. The final part will tease out some conclusions with respect to urban sustainability.
Combined Surgical Method of Orbital and Periorbital Hemangioma Treatment in Infants

Purpose: To analyze the results of application of combined surgical treatment in different forms of hemangioma in infants. Materials and Methods: One hundred seventy-four children with different forms of orbital and periorbital hemangiomas aged 1–16 months (mean age 5.2 + 1.97 months) were operated on at the pediatric ophthalmology department. Fast growth of hemangioma, both superficial (intradermal) and deep (subdermal and orbital) localization, significant deformity of eyelids, with narrowing of eye fissure were the indications for surgical treatment. The combined-staged method, including cryosurgery of superficial intradermal lesions and surgical excision of subdermal and/or orbital parts of the tumor in different combinations depending on the form and depth of hemangioma spreading, was applied. Results: Usage of cryodestruction usually on the first stage of treatment allowed gentle scarring of the angiomatously changed skin areas. Surgical excision of the deep part of the tumor eliminated disfigurement and visual axis occlusion, avoiding amblyopia development. Good cosmetic and anatomic result was achieved in 90.4% of cases. Conclusion: Combined surgical method of treatment of progressive capillary hemangiomas by using cryosurgery and surgical excision in infants allows the choice of optimum tactics depending on features of the course and clinical picture in each individual case and provides achievement of high cosmetic and functional result of treatment. The early beginning of treatment in cases of fast progressing of the tumor allows prevention of extensive skin affection and amblyopia development.
Interleukin-1-induced promotion of T-cell differentiation in mice immunized with killed Listeria monocytogenes

We studied the effects of administration of recombinant interleukin-1 alpha (rIL-1 alpha) to mice after immunization with killed Listeria monocytogenes cells on the promotion of the functional differentiation of T cells in vivo. Mice immunized with killed L. monocytogenes were unable to express cell-mediated immunity to specific antigen in vivo, as determined by delayed-type hypersensitivity (DTH) and acquired cellular resistance (ACR), and splenic T cells obtained from such mice were unable to respond to rIL-2 and specific antigen and to produce IL-2 after antigenic restimulation in vitro. When rIL-1 alpha was given to mice after immunization with killed bacteria. T cells became capable of responding to rIL-2 and specific antigen in vitro. These functions of T cells were similar to those from mice immunized with viable listeriae. Moreover, using a local passive transfer system, it was found that effector T cells mediating DTH but not ACR to L. monocytogenes were generated in mice treated with rIL-1 alpha after immunization with killed bacteria. These T cells were able to produce macrophage chemotactic factor but not macrophage-activating factor or gamma interferon in vitro in response to stimulation with specific antigen. These results suggest that in vivo administration of rIL-1 alpha facilitates the maturation of antigen-specific T cells mediating DTH and that different effector T cells mediating DTH or ACR are involved in cell-mediated immunity to L. monocytogenes.
Effects of drought stress on global gene expression profile in leaf and root samples of Dongxiang wild rice (Oryza rufipogon)

Drought is a serious constraint to rice production throughout the world, and although Dongxiang wild rice (Oryza rufipogon, DXWR) possesses a high degree of drought resistance, the underlying mechanisms of this trait remains unclear. In the present study, cDNA libraries were constructed from the leaf and root tissues of drought-stressed and untreated DXWR seedlings, and transcriptome sequencing was performed with the goal of elucidating the molecular mechanisms involved in drought-stress response. The results indicated that 11231 transcripts were differentially expressed in the leaves (4040 up-regulated and 7191 down-regulated) and 7025 transcripts were differentially expressed in the roots (3097 up-regulated and 3928 down-regulated). Among these differentially expressed genes (DEGs), the detection of many transcriptional factors and functional genes demonstrated that multiple regulatory pathways were involved in drought resistance. Meanwhile, the DEGs were also annotated with gene ontology (GO) terms and key pathways via functional classification and Kyoto Encyclopedia of Gene and Genomes (KEGG) pathway mapping, respectively. A set of the most interesting candidate genes was then identified by combining the DEGs with previously identified drought-resistant quantitative trait loci (QTL). The present work provides abundant genomic information for functional dissection of the drought resistance of DXWR, and findings will further help the current understanding of the biological regulatory mechanisms of drought resistance in plants and facilitate the breeding of new drought-resistant rice cultivars.
Decomposing Service Exports Adjustments Along the Intensive and Extensive Margin at the Firm‐Level

Using a panel-data set of Austrian service exporting firms this paper examines the determinants of service exports at the firm-destination country level. We implement a random-effects Heckman sample selection firm-level gravity model as well as a fixed effects Poisson model. Expected firm-level service exports are decomposed into the intensive and extensive margins of adjustment as a response to counterfactual changes. We find market demand to be the key determinant. Results also suggest high service export potentials due to regulatory reform in partner countries within the EU. Adjustments at the extensive margin only play a marginal role. Increasing firm size as well as changes in distance related costs are most effective in developing new export relationships in services.
Treating fallopian tube occlusion with a manual pelvic physical therapy.

OBJECTIVE To determine the efficacy of a non-invasive, manual soft-tissue physical therapy in opening completely blocked fallopian tubes in infertile women with confirmed bilateral occlusion and a history indicative of abdominopelvic adhesions. DESIGN Retrospective analysis. SETTING Clear Passage Therapies, Inc, clinic, Gainesville, Florida. PATIENTS 28 infertile women (mean age = 35.2) with diagnosed complete tubal occlusion (proximal, midtubal, distal, or combination). The patients were being treated for various types of abdominopelvic pain and dysfunction (eg, intercourse and/or pelvic pain, menstrual cramps, endometriosis pain). INTERVENTION A 20-hour series of manual physical therapy treatments (mean duration = 1 week) designed to address pain and restricted soft tissue mobility due to adhesions and micro-adhesions. The therapists accessed some of the deeper structures (such as the fallopian tubes) indirectly by manipulating the peritoneum, uterine and ovarian ligaments, and neighboring structures. MAIN OUTCOME MEASURES (1) Unilateral or bilateral tubal patency confirmed by diagnostic test or natural intrauterine pregnancy; (2) natural intrauterine pregnancy rate achieved by patent patients within the 2-year follow-up period. RESULTS Of the 28 patients, 17 (61%, 95% exact CI 41%-78%) demonstrated post-treatment unilateral or bilateral patency, as measured by hysterosalpingography or natural intrauterine pregnancy. The median interval between the last treatment date and patency confirmation was 1 month. Nine of the 17 (53%) patent patients reported a subsequent natural intrauterine pregnancy. CONCLUSION Since truly occluded tubes are not known to reopen spontaneously, the results suggest this non-invasive therapy might be considered as an adjuvant to standard gynecological procedures in treating tubal occlusion.
Triage Nurse Initiation of Corticosteroids in Pediatric Asthma Is Associated With Improved Emergency Department Efficiency

OBJECTIVE: To assess the effectiveness of nurse-initiated administration of oral corticosteroids before physician assessment in moderate to severe acute asthma exacerbations in the pediatric ED. METHODS: A time-series controlled trial evaluated nurse initiation of treatment with steroids before physician assessment in children with Pediatric Respiratory Assessment Measure score ≥4. One-to-one periods (physician-initiated and nurse-initiated) were analyzed from September 2009 through May 2010. In both phases, triage nurses initiated bronchodilator therapy before physician assessment, per Pediatric Respiratory Assessment Measure score. We reviewed charts of 644 consecutive children aged 2 to 17 years for the following outcomes: admission rate; times to clinical improvement, steroid receipt, mild status, and discharge; and rate of return ED visit and subsequent admission. RESULTS: Nurse-initiated phase children improved earlier compared to physician-initiated phase (median difference: 24 minutes; 95% confidence interval [CI]: 1–50; P = .04). Admission was less likely if children received steroids at triage (odds ratio = 0.56; 95% CI: 0.36–0.87). Efficiency gains were made in time to steroid receipt (median difference: 44 minutes; 95% CI: 39–50; P < .001), time to mild status (median difference: 51 minutes; 95% CI: 17–84; P = .04), and time to discharge (median difference: 44 minutes; 95% CI: 17–68; P = .02). No differences were found in return visit rate or subsequent admission. CONCLUSIONS: Triage nurse initiation of oral corticosteroid before physician assessment was associated with reduced times to clinical improvement and discharge, and reduced admission rates in children presenting with moderate to severe acute asthma exacerbations.
Drivers of local people’s participation in sustainable natural resource management: a case study in central Iran

ABSTRACT The driving forces behind natural resource management (NRM) vary among countries. Most NRM programmes focus on biophysical drivers such as soil, water and vegetation, with little attention directed towards the nuanced sociocultural and religious drivers of sustainable natural resource management (SNRM) practices. This paper explores those understudied drivers that influence local people’s participation (LPP) in SNRM in Isfahan, Iran. Using a multi-stage stratified sampling method, we selected 200 natural resource experts and natural resource users to complete a questionnaire about their perceptions of SNRM. Results reveal that sociocultural and religious beliefs are the major drivers of SNRM. The results also indicate that subsidiary drivers include: a sense of responsibility towards SNRM; the conviction that natural resources belong to God and should therefore be preserved; participation to preserve natural resources because of training courses and media influence; a long-established custom of preserving natural resources; and the specific impact of environmental television programmes. Demographic analysis finds a significant relationship between educational level and LPP in SNRM. This study’s results therefore suggest that natural resource managers would benefit from a deeper understanding of the local sociocultural and religious contexts that motivate people to participate in SNRM.