Miracle-dz/UniFAR-FTUs huggingface dataset:
Examination of Turkish University Students’ Internet Addiction in Relation to Their Parental Attachment Styles and Sociodemographics

The purpose of this study was to examine university students’ Internet addiction in relation to their parental attachment and sociodemographics. The participants consisted of 402 university students aged 17 to 25 years, 249 (61.9%) of whom were female and 153 (38.1%) of whom were male. The participants completed a questionnaire comprising the Parental Bonding Instrument (PBI), the Internet Addiction Test–Short Version (IAT-SV), and a personal information form. The data were analyzed using the Pearson product-moment correlation coefficient, multiple regression analysis, and one-way analysis of variance (ANOVA). The results of the one-way ANOVA suggested that students whose fathers had low educational levels were more likely to have higher Internet addiction scores than those students whose fathers had high educational levels. The results of the Pearson product-moment correlation coefficient suggested that university students’ Internet addiction scores were negatively correlated with their age, grade point average, maternal care, maternal overprotection, paternal care, and paternal overprotection. However, the results of a stepwise regression analysis suggested that the most important predictors of Internet addiction scores were maternal overprotection and paternal overprotection; the results also suggested that age, grade point average, maternal care, paternal care, and father’s educational level did not explain the additional variance in Internet addiction scores above and beyond the maternal overprotection and paternal overprotection scores.
The effects of dietary oil inclusion and oil source on apparent digestibility, faecal volatile fatty acid concentration and manure ammonia emission

An investigation was conducted to test the hypothesis that dietary oil inclusion increases ammonia nitrogen (NH3-N) emission from the manure, due to a negative effect of either unsaturated or saturated oil on microbial activity in the intestine. Dietary oil was included at 45 g/kg, as either crude palm oil (PO), soya oil (SO) or a 50: 50 SO: PO blend (OB), to a basal barley-soya-wheat diet (control) at the expense of dextrose and maize starch. Diets were formulated to contain 13·2 MJ digestible energy per kg and 11·0 g/kg lysine. Four boars were assigned to each dietary treatment, and were transferred to metabolism crates (mean live weight, 74·0 (± 2·89) kg) following 14 days dietary acclimatization. Urine and faeces were collected separately over a 5-day digestibility/nitrogen (N) balance period and a 2-day manure collection period. Inclusion of dietary oil increased apparent digestibility of oil (P < 0·01) and decreased the apparent digestibility of dry matter (P < 0·01) and gross energy (P < 0·05). Dietary oil did not affect the apparent digestibility of nitrogen, acid-detergent fibre, neutral-detergent fibre or hemicellulose. Apparent digestibility of oil was lower when oil was included as PO compared with SO and OB (P < 0·001). The concentration of faecal volatile fatty acid (VFA) was similar in all treatments, although the acetic: propionic acid ratio was lower when oil was included as PO and OB compared with SO (P < 0·05). N balance, manure N concentration and NH3-N emission was not affected by oil inclusion or oil source. In conclusion, dietary oil inclusion reduced apparent dry matter and energy digestibilities, although no effect on fermentation was indicated by digestibility of fibre or faecal VFA content. Consequently, ammonia emission was not affected by dietary oil included at 45 g/kg.
Procedural Justice, Legitimacy, and the Effective Rule of Law

Legal authorities gain when they receive deference and cooperation from the public. Considerable evidence suggests that the key factor shaping public behavior is the fairness of the processes legal authorities use when dealing with members of the public. This reaction occurs both during personal experiences with legal authorities and when community residents are making general evaluations of the law and of legal authorities. The strength and breadth of this influence suggests the value of an approach to regulation based upon sensitivity to public concerns about fairness in the exercise of legal authority. Such an approach leads to a number of suggestions about valuable police practices, as well as helping explain why improvements in the objective performance of the police and courts have not led to higher levels of public trust and confidence in those institutions.
Fluoro-deoxyglucose positron emission tomography in diffuse Lewy body disease

We report six demented individuals with pathologically verified diffuse Lewy body disease (DLBD) studied with fluoro-deoxyglucose positron emission tomography (FDG-PET). Three subjects had pure DLBD and three subjects had combined DLBD and Alzheimer's disease (DLBD-AD) pathology. FDG-PET revealed evidence of diffuse cerebral hypometabolism in both pure DLBD and DLBD-AD with marked declines in association cortices with relative sparing of subcortical structures and primary somatomotor cortex, a pattern reported previously in AD. Unlike AD, however, these subjects also had hypometabolism in the occipital association cortex and primary visual cortex. These findings indicate the presence of diffuse cortical abnormalities in DLBD and suggest that FDG-PET may be useful in discriminating DLBD from AD antemortem. NEUROLOGY 1996;47: 462-466
MicroRNA-206 Targets notch3, Activates Apoptosis, and Inhibits Tumor Cell Migration and Focus Formation*

MicroRNAs contribute to cancer development by acting as oncogenes or tumor suppressor genes. However, only a few microRNA target genes were determined. We identified a nearly perfect complementarity between miR-206 and the 3′-untranslated regions of both mouse and human notch3. Expression of miR-206 decreased the luciferase activity dose-dependently when cotransfected with the mouse or human notch3 3′-untranslated region-luciferase reporter containing the miR-206 target site in HeLa cells. This suppression was relieved by deletion and mutation of the miR-206-binding site and was partially recovered by expression of notch3 or by a specific inhibitor of miR-206. Interestingly, overexpression of miR-206 decreased the levels of both Notch3 protein and mRNA. Expression of miR-206 markedly induced apoptotic cell death and blocked the anti-apoptotic activity of Notch3. In addition, ectopic expression of miR-206 inhibited HeLa cell migration and focus formation. Therefore, we identified miR-206 as a pro-apoptotic activator of cell death, which was associated with its inhibition of notch3 signaling and tumor formation. The inhibition of cancer cell migration and focus formation by miR-206 strongly suggests that miR-206 may function as a novel tumor suppressor.
Gist or Gant?

To THE EDITOR: I have read with great interest the article reported by Yantiss et al entitled "Gastrointestinal stromal tumors: An ultrastructural study" [1]. First, I would like to congratulate the authors for their elegant illustration of ultrastructural features of gastrointestinal stromal tumors. The authors report the majority of gastrointestinal stromal tumors (GIST) they have studied, particularly those located in the small intestine, revealed features of neural differentiation such as presence of dense core granules, axon-like cell processes, bulbous endings with synaptic vesicles, and synapse-like junctions. In spite of such findings, the authors concluded that the ultrastructural features of GIST confirmed those of interstitial cells of Cajal (ICC), supporting the claim that ICC are the progenitor cells of GIST [2]. In this regard, note that the features of neural differentiation they have depicted in their cases of GIST are identical to the diagnostic features of gastrointestinal autonomic nerve tumors (GANT) [3]. GANT were first described by Herrera et al [4] and thought to be tumors derived from the gastrointestinal autonomic nerve. Their existence has been repeatedly documented [2,4,5]. It appears that many cases of GANT were included in the series of GIST reported by the authors. This presents a few serious questions. Interstitial cells of Cajal were first reported by Cajal more than a century ago as a third cell network in the supravitally stained (methylene blue) preparations of freshly crushed intestinal tissue, in addition to nerves and muscle cells. According to Cajal, interstitial cells were the intercalating cells between nerves and muscle cells. They were neither nerve cells nor muscle cells. He postulated a possible accessory neural function since they were found along the nerves. During the past 100 years, our understanding of ICC evolved to reach the current concept that ICC are pacemaker cells of the gastrointestinal tract [6]. The current concept derives in part from efforts of many investigators who attempted to characterize ICC ultrastructurally. Initially, these investigators experienced great difficulties in identifying ICC under the electron microscope, since there was no good known marker. Nevertheless, the findings of investigators, including Thuneberg [6] and Faussone-Pellegrini et al. [7], serve as the standard references for other investigators. It is now accepted that ICC consist of a few different cell types: fibroblast-like, muscle celllike, and hybrid cells. The types of ICC vary according to the level of the gastrointestinal tract and different layers of the intestinal wall in which they are found. According to these investigators, ICC were located between the nerves and muscle cells. ICC
An execution-backtracking approach to debugging

Spyder, a system for selective checkpointing of computational sequences, is presented. It lets users backtrack from checkpoints without the need to reexecute the program to reach recent prior states. In contrast to more comprehensive (and storage-intensive) checkpointing schemes, backtracking in this approach is constrained to limit storage requirements. The resulting debugger offers a structured view of dynamic events, similar to lexical scope rules' effect on static visibility. The debugger also speeds backtracking to statements before loops and provides what-if capabilities. <<ETX>>
Depressive Symptoms and Oral Contraceptives

Of 261 women who completed a self-rating scale for measuring depression, 168 were taking oral contraceptives and 93 were using physical methods of contraception. Of the group of women taking oral contraceptives 6·6% were more severely depressed than any of the control group. There was a significant variation in the depth of depression related to the day of the menstrual cycle in the control group. This association was not found in the oral contraceptive group, where premenstrual depression was limited to the one or two days preceding menstruation. Women taking a contraceptive containing lynoestrenol 2·5 mg. and mestranol 0·075 mg. showed a significantly increased incidence of pessimism, feelings of dissatisfaction, crying, and tension, compared with women taking other oral contraceptives and the control group.
Monthly measurements of indoor allergens and the influence of housing type in a northeastern US city

Background: We examined seasonal variation of dust‐mite (Der f 1 and Der p 1), cat (Fel d 1), and cockroach (Bla g 1) allergens in Boston, while adjusting for other covariates. Limited data are available on seasonal patterns of indoor allergen concentrations for different geographic regions in the USA. Understanding within‐home seasonal variation of allergens is important epidemiologically and clinically.
Length of the Y Chromosome and Chromosomal Variants in Inpatient Children with Psychiatric Disorders: Two Studies

In a study of 41 inpatient boys with psychiatric disorders, it was found that this group had significantly increased length of the long arm of the Y chromosome (Yq+) as compared to a normal control group. The length of the Y chromosome in the inpatient group correlated with psychiatric symptom severity, hyperactivity, parental psychopathology and paternal alcoholism. A further study of minor chromosomal variants in 56 inpatient boys and girls revealed no differences in individual or pooled variants in the patient group, as compared to the control group. However, those in the patient group with one or more variants showed more severe psychiatric and other psychosocial symptoms than those in the group without variants. Those who had both longer Y chromosomes and a minor chromosomal variant had more severe psychiatric symptom severity.
Interferon beta: Medication which started the revolution in the treatment of multiple sclerosis

Multiple sclerosis is a chronic, inflammatory, demyelinating and neurodegenerative disease of the central nervous system. The etiology is unknown, and it is estimated that about 2.5 million people all around the world are suffering from this disease. It is the most common cause of non-traumatic disability in young adults. The clinical presentation is very variable and unpredictable. There are three basic forms of the disease – relapsing remitting, primary progressive and secondary progressive multiple sclerosis. The prognosis for these patients has changed since 1993, when the first disease modifying therapy – interferon beta, was approved. Interferon beta reduces the number of relapses, reduces the number of hyper intense lesions on T2 sequences of endocranial MRI, mildly delaying the progression of the disease. Interferon beta is also used in pediatric population. It is considered to be generally safe, since it does not increase the likelihood of developing malignancy and opportunistic infections.
Reduced cystatin B activity correlates with enhanced cathepsin activity in progressive myoclonus epilepsy

BACKGROUND: Loss-of-function mutations in the gene encoding cystatin B (CSTB) underlie an inherited neurodegenerative disorder, progressive myoclonus epilepsy of Unverricht-Lundborg type (EPM1). CSTB is an inhibitor of several papain-family cysteine proteases, the lysosomal cathepsins. Its physiological function and the molecular pathways leading to the clinical EPM1 phenotype are unknown. AIM: To elucidate the role of CSTB and different cathepsins in pathogenesis of EPM1. METHOD: We determined the total papain inhibitory (cystatin) and papain-like (cathepsin) activity as well as specific activities of cathepsins B, H, L and S in lymphoblastoid cells of EPM1 patients, carriers and controls. RESULTS: In EPM1 patients, who express reduced levels of CSTB mRNA, the papain inhibitory activity was significantly decreased or absent. This reduction was correlated with significant increase in general cathepsin activity. The increase in cathepsin B, L and S activities was highly significant, whereas the increase in cathepsin H activity was not. CONCLUSIONS: This is the first demonstration of cysteine protease activity being regulated by CSTB activity in a biological context. The effects of decreased CSTB activity in EPM1 pathogenesis may, at least in part, be mediated by cathepsins through increased activity of cathepsins S and L.
Older adults with limited literacy are at increased risk for likely dementia.

BACKGROUND Low literacy is common among the elderly and possibly more reflective of educational attainment than years of school completed. We examined the association between literacy and risk of likely dementia in older adults. METHODS Participants were 2,458 black and white elders (aged 71-82) from the Health, Aging and Body Composition study, who completed the Rapid Estimate of Adult Literacy in Medicine and were followed for 8 years. Participants were free of dementia at baseline; incidence of likely dementia was defined by hospital records, prescription for dementia medication, or decline in Modified Mini-Mental State Examination score. We conducted Cox proportional hazard models to evaluate the association between literacy and incidence of likely dementia. Demographics, education, income, comorbidities, lifestyle variables, and apolipoprotein E (APOE) ε4 status were included in adjusted analyses. RESULTS Twenty-three percent of participants had limited literacy (<9th-grade level). Limited literacy, as opposed to adequate literacy (≥9th-grade level), was associated with greater incidence of likely dementia (25.5% vs17.0%; unadjusted hazard ratio [HR] = 1.75, 95% confidence interval 1.44-2.13); this association remained significant after adjustment. There was a trend for an interaction between literacy and APOE ε4 status (p = .07); the association between limited literacy and greater incidence of likely dementia was strong among ε4 noncarriers (unadjusted HR = 1.85) but nonsignificant among ε4 carriers (unadjusted HR = 1.25). CONCLUSIONS Limited literacy is an important risk factor for likely dementia, especially among APOE ε4-negative older adults, and may prove fruitful to target in interventions aimed at reducing dementia risk.
The multi-channel cochlear implant: Past, present and future perspectives

Abstract Initial research demonstrated that only low frequencies could be mimicked with rate of electrical stimulation, and thus multi-channel rather than single-channel stimulation was required for the place coding of the mid-high speech frequencies. Place coding of mid-high frequencies was best achieved with electrodes inside the cochlea. Furthermore, correct biomechanical properties of a multiple electrode bundle were required for it to pass around the cochlear spiral to the speech frequency region. Biological studies showed too that intra-cochlear electrodes could be used with minimal trauma, safe electrical stimulus parameters, and methods to prevent inner ear infection and meningitis. The crucial discoveries for coding speech with electrical stimulation have been based on the discovery of: 1) the fact the brain processes frequency information along spatial and temporal channels, and 2) that the first patient experienced vowels when stimulating different electrodes that corresponded to the place of excitation for single formant vowels in people with normal hearing. The inaugural and subsequent speech processing strategies extracted frequencies of special importance for speech intelligibility, and transmitted the information along place coding channels. The voicing frequency and/or amplitude, was coded as temporal information across these spatial channels. As a result a great majority of severely-to-profoundly deaf people with previous hearing can not only communicate when electrical stimulation is combined with lipreading, but with electrical stimulation alone. In addition, the benefits of binaural hearing with bilateral cochlear implants or an implant in one ear and hearing aid in the other ear have been realized. Related psychophysical research has discovered the basic perceptual skills that process the complex patterns of brain excitation that underlie speech recognition both in the one ear as well as bilateral implants. In addition the development of the perceptual skills in the maturing child for speech recognition, have been discovered. In the future high fidelity sound should be achieved by providing the fine temporo-spatial patterns of excitation and preserving the peripheral nerve network. This could require the release of nerve growth factors and the development of electrodes using nanotechnology. Copyright © 2009 John Wiley & Sons, Ltd.
Attention-Deficit/Hyperactivity Disorder: A Review of Research on Movement Skill Performance and Physical Fitness

The purpose of this study was to present a comprehensive review of research on the movement performance and physical fitness of children with attention-deficit/hyperactivity disorder (ADHD) and offer research recommendations. Movement behaviors of children with ADHD were described on the basis of 49 empirical studies published between 1949 and 2002. Major results indicated that (a) children with ADHD are at risk for movement skill difficulties, (b) children with ADHD are at risk for poor levels of physical fitness, (c) comorbidity may exist between ADHD and developmental coordination disorder (DCD), and (d) few interventions have focused on movement performance and physical fitness of children with ADHD. Numerous reference citations for seminal review articles on ADHD are provided so that potential researchers or program planners might enter the vast ADHD literature with some ease.
Skin lesion segmentation: U-Nets versus clustering

Many automatic skin lesion diagnosis systems use segmentation as a preprocessing step to diagnose skin conditions because skin lesion shape, border irregularity, and size can influence the likelihood of malignancy. This paper presents, examines and compares two different approaches to skin lesion segmentation. The first approach uses U-Nets and introduces a histogram equalization based preprocessing step. The second approach is a C-Means clustering based approach that is much simpler to implement and faster to execute. The Jaccard Index between the algorithm output and hand segmented images by dermatologists is used to evaluate the proposed algorithms. While many recently proposed deep neural networks to segment skin lesions require a significant amount of computational power for training (i.e., computer with GPUs), the main objective of this paper is to present methods that can be used with only a CPU. This severely limits, for example, the number of training instances that can be presented to the U-Net. Comparing the two proposed algorithms, U-Nets achieved a significantly higher Jaccard Index compared to the clustering approach. Moreover, using the histogram equalization for preprocessing step significantly improved the U-Net segmentation results.
Effect of tibial plateau leveling on stability of the canine cranial cruciate-deficient stifle joint: an in vitro study.

OBJECTIVE To evaluate the effect of tibial plateau leveling on joint motion in canine stifle joints in which the cranial cruciate ligament (CCL) had been severed. STUDY DESIGN In vitro cadaver study. ANIMALS Six canine cadaver hind legs. METHODS Radiographs of the stifle joints were made to evaluate the tibial plateau angle with respect to the long axis of the tibia. The specimens were mounted in a custom-made testing device to measure cranio-caudal translation of the tibia with respect to the femur. An axial load was applied to the tibia, and its position was recorded in the normal stifle, after transection of the CCL, and after tibial plateau leveling. Further, the amount of caudal tibial thrust was measured in the tibial plateau leveled specimen while series of eight linearly increasing axial tibial loads were applied. RESULTS Transection of the CCL resulted in cranial tibial translation when axial tibial load was applied. After tibial plateau leveling, axial loading resulted in caudal translation of the tibia. Increasing axial tibial load caused a linear increase in caudal tibial thrust in all tibial plateau-leveled specimens. CONCLUSIONS After tibial plateau leveling, axial tibial load generates caudal tibial thrust, which increases if additional axial load is applied. CLINICAL RELEVANCE Tibial plateau leveling osteotomy may prevent cranial translation during weight bearing in dogs with CCL rupture by converting axial load into caudal tibial thrust. The amount of caudal tibial thrust seems to be proportional to the amount of weight bearing.