Miracle-dz/UniFAR-FTUs huggingface dataset:
Determinants of Latinx Patients’ Perceptions of Trust in their Physicians at the Primary Health Care Level

This study examines the predictors of Latinx patient’s trust in their primary healthcare providers. Specifically, this study tests patient and physician characteristics that contribute to feelings of trust in the healthcare setting. Latinx adults from primary care clinics in Southern California and a legal aid office in Canton, Ohio, completed surveys on their perceptions of cultural sensitivity, compassion, and communication received from their physicians in addition to overall feelings of trust toward their physicians. Surveys also asked participants about their language preference, generational status, and demographics. Data was analyzed using a linear multiple regression model with trust as the dependent variable. The results indicate that physician’s compassion and patient’s age are significant predictors of the level of trust Latinx patients have toward their physicians. The finding on compassion can inform physician training for the future and shape Latinx patients’ experiences in healthcare within the United States, fostering an environment of trust.
Experience of hysteroscopy in a rural tertiary care center of Haryana, India

Background: During the last few decades hysteroscopy has become a tool of choice for evaluation of uterine cavity due to its “see and treat “benefits. It is more accurate and less invasive. Introduction of hysteroscopy in gynecological practice is the need of time. Aim of our study is to share the experience of hysteroscopy, its learning curve and limitations in a rural tertiary care center of Haryana.Methods: We retrospectively analyzed all the hysteroscopy procedure done from January 2016 to December 2018 from the hospital records.Results: Total 118 hysteroscopy were done but record of only 110 was available. Out of 110, 37(33%) were operative and 73(67%) were diagnostic. 36% were done for AUB, 33% for infertility, 15% for misplaced cu t, 6% for amenorrhea, 2% in cases of RPL and rest for some less common indications. Out of operative hysteroscopy major procedures done were polypectomy and removal of misplaced Cu-T. Septal resection was also done in 3 cases. Number of operative hysteroscopy has increased over the time period of study.Conclusions: Hysteroscopic evaluation of uterine cavity is a reliable method for both diagnostic and treatment purpose. Proportion of hysteroscopy procedures and its learning curve will improve with persistent effort.
Application Of Adoptive Immunotherapy In Ovarian Cancer

Abstract Ovarian cancer (OC) has been the most fatal gynecological disease that threatens women’s health. Surgery and platinum-based chemotherapy are the basic ovarian cancer treatments that can improve survival, but the five-year survival rate has not improved because of delayed diagnosis, drug resistance, and recurrence. Novel treatments are needed to improve the prognosis and survival rate of ovarian cancer patients. In recent years, adoptive cell therapy (ACT) has received increasing attention as an emerging therapeutic strategy in the treatment of solid tumors including OC. ACT has shown promising results in many preclinical and clinical trials of OC. The application of ACT depends on different effector cells, such as lymphokine-activated killer (LAK) cells, tumor-infiltrating lymphocytes (TILs), and genetically modified T cells. In this review, we focus on adoptive immunotherapies in ovarian cancer and summarize completed and ongoing preclinical/clinical trials. The future development directions and obstacles for ACT in OC treatment are discussed.
A Diet Induced Maladaptive Increase in Hepatic Mitochondrial DNA Precedes OXPHOS Defects and May Contribute to Non-Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease (NAFLD), an increasingly prevalent and underdiagnosed disease, is postulated to be caused by hepatic fat mediated pathological mechanisms. Mitochondrial dysfunction is proposed to be involved, but it is not known whether this is a pathological driver or a consequence of NAFLD. We postulate that changes to liver mitochondrial DNA (mtDNA) are an early event that precedes mitochondrial dysfunction and irreversible liver damage. To test this hypothesis, we evaluated the impact of diet on liver steatosis, hepatic mtDNA content, and levels of key mitochondrial proteins. Liver tissues from C57BL/6 mice fed with high fat (HF) diet (HFD) and Western diet (WD, high fat and high sugar) for 16 weeks were used. Steatosis/fibrosis were assessed using haematoxylin and eosin (H&E) Oil Red and Masson’s trichome staining and collagen content. Total DNA was isolated, and mtDNA content was determined by quantifying absolute mtDNA copy number/cell using quantitative PCR. Selected mitochondrial proteins were analysed from a proteomics screen. As expected, both HFD and WD resulted in steatosis. Mouse liver contained a high mtDNA content (3617 ± 233 copies per cell), which significantly increased in HFD diet, but this increase was not functional, as indicated by changes in mitochondrial proteins. In the WD fed mice, liver dysfunction was accelerated alongside downregulation of mitochondrial oxidative phosphorylation (OXPHOS) and mtDNA replication machinery as well as upregulation of mtDNA-induced inflammatory pathways. These results demonstrate that diet induced changes in liver mtDNA can occur in a relatively short time; whether these contribute directly or indirectly to subsequent mitochondrial dysfunction and the development of NAFLD remains to be determined. If this hypothesis can be substantiated, then strategies to prevent mtDNA damage in the liver may be needed to prevent development and progression of NAFLD.
A Genome-Wide Association Study Identifies Five Novel Genetic Markers for Trastuzumab-Induced Cardiotoxicity in Japanese Population.

Trastuzumab has been administered to patients with HER2-positive cancer, however, the cardiotoxicity is identified as one of the life-threatening toxicities. Clinically useful biomarker for trastuzumab-induced cardiotoxicity has been expected to be developed. To identify a novel genetic marker(s) determining the risk of trastuzumab-induced cardiotoxicity, we performed a first genome-wide association study (GWAS) in Japanese population. We enrolled 481 patients who had been treated with trastuzumab and carried out a GWAS using 11 cases (with cardiotoxicity) and 257 controls (without cardiotoxicity). Top 100 single nucleotide polymorphisms (SNPs) which revealed the smallest P values in GWAS (P = 7.60 x 10-7 - 2.01 x 10-4) were further examined using replication samples consisted of 14 cases and 199 controls. The combined analysis of the GWAS and replication study indicated possible association of five loci with trastuzumab-induced cardiotoxicity (rs9316695 on chromosome 13q14.3, rs28415722 on chromosome 15q26.3, rs7406710 on chromosome 17q25.3, rs11932853 on chromosome 4q25, and rs8032978 on chromosome 15q26.3, Pcombined = 6.00 x 10-6, 8.88 x 10-5, 1.07 x 10-4, 1.42 x 10-4, 1.60 x 10-4, respectively). Furthermore, we developed a risk prediction model for trastuzumab-induced cardiotoxicity using the five marker SNPs. The incidence of trastuzumab-induced cardiotoxicity in patients with risk score ≥ 5 was significantly higher (42.5%) compared to that in patients with score ≤ 4 (1.8%) (P = 7.82 x 10-15, odds ratio = 40.0). These findings suggest the potential to improve the ability of physicians to avoid the trastuzumab-induced cardiotoxicity for patients with HER2-positive cancer.
A vibrotactile interface to support the driver during the take-over process

When a conditionally automated system reaches its functional limits a request to intervene will be presented and the driver needs to perform a takeover. Traditional visual and auditory displays might not be effective warnings, when a driver is engaged in visually or auditory loading non-driving tasks, like reading or talking on the phone. Vibrotactile displays are expected to be effective as a take-over request and could potentially be used to direct the attention of the driver or convey more complex messages. The aim of this thesis if to evaluate how a vibrotactile interface can support the driver during the take-over process and how to incorporate such an display in a multimodal interface.
Analisis Penerimaan Digital Library Menggunakan Technology Acceptance Model (TAM) di Universitas Hamzanwadi

The study aims to analyze acceptance digital library implementation using TAM model by analyze: (1) the effect perceived usefulness, perceived ease of use toward behavioral intention to use (2) the effect perceived usefulness, perceived ease of use, and behavioral intention to use toward actual system use. This research is a quantitative study using a survey method which was implemented at Hamzanwadi University. The population of this study was 6,548 people and the number of sample was 100 people contain of students. The sampling technique used was a cluster sampling method. While, the data collection used was a questionnaire with Likert scale. Data Analysis used Structural Equation Model (SEM). The results of this study showed that, (1) perceived ease of use had a significant influence toward behavioral intention to use (ρ 0.05), (4) behavioral intention to use had a significant toward actual system use (ρ <0.05).
Pengaruh Model Pembelajaran Kooperatif Tipe Think Pair Share (TPS) berbantuan Pendekatan Investigasi terhadap Kemampuan Komunikasi Matematis

Mathematical communication ability of learners is still relatively low, this is allegedly caused by the conventional learning model that is still applied by educators. The authors in this study apply cooperative type model of TPS assisted investigative approach, because the type and approach is expected to be suitable to improve the mathematical communication ability of learners. The purpose of this research is to see the effect of Cooperative Learning Model Type Think Pair Share (TPS) assisted by an Investigation Approach to Mathematical Communication Ability. In this research including quantitative research because the data is processed in the form of numbers. Use experimental experimental quasy experiment type. To know the effect on the ability of mathematical communication owned peserta didiksetelah applied learning model is the purpose of the implementation of research. The instrument in this research is the test of mathematical communication ability on the matter of scale and comparison. Further data that have been obtained will be calculated by using Analysis of Variance (ANAVA) one unequal cell road. The result of this research is there is influence of thinking pair share learning model assisted by investigative approach to mathematical communication ability of learner, which in class which applied by model of learning pair help coupled with better investigation of mathematical communication ability compared with conventional learning model and TPS learning model.
Controlled delivery of antimicrobial and anti-inflammatory agents from un-cemented prosthesis

The prevalence of joint replacement procedure increased by more than 119% in the last decade as a result to that the demand for a prosthesis is very likely to increase. Uncemented prosthesis is the first-choice treatment option for patient age less than 68 years, due to its long-term and more stable fixation. The two major limitations that lead to the failure of joint replacement surgery are a prosthetic joint infection and aseptic loosening. To encounter these limitations this study aimed to develop a coating that can control the release of the antimicrobial agent (chlorhexidine) and the anti-inflammatory agent (dexamethasone) to provide prophylaxis from postsurgical inflammation and infection. The antibacterial and anti-inflammatory coating was built initially on titanium nanoparticles followed by the validation on the medical grade Ti alloys surfaces. The multilayer coating was achieved employing a Layer by Layer (LbL) technology incorporating a drug of interest between polyelectrolyte layers of alginate and poly-beta amino esters. Physico-chemical characterisations of the obtained nanoparticles were conducted, and amount of chlorhexidine and dexamethasone released from the multi-layered system was quantified. Cytotoxicity and anti-inflammatory activity were assessed in in-vitro human macrophage cellular model, also cytocompatibility towards human osteoblasts cells were examined. The results showed that chlorhexidine was released in a controlled manner for 60 days from the nanoparticular system providing inhibition of growth for a number of clinically relevant gram- positive and gram-negative bacterial strains. Dexamethasone released for up to 30 days was able to suppress TNF-α and IL-6 production. Study on Ti alloys surfaces confirmed the efficacy of the multi-layered systems. Moreover, no cytotoxic effects were observed towards osteoblasts surrounding prosthetic device confirming not just efficacy but also a safety of the proposed system.
Distinct gene expression characteristics in epithelial cell-Porphyromonas gingivalis interactions by integrating transcriptome analyses

Porphyromonas gingivalis is a pivotal periodontal pathogen, and the epithelial cells serve as the first physical barrier to defend the host from bacterial attack. Within this host-bacteria interaction, P. gingivalis can modify the host immune reaction and adjust the gene expression, which is associated with periodontitis pathogenesis and developing strategies. Herein, a meta-analysis was made to get the differential gene expression profiles in epithelial cells with or without P. gingivalis infection. The network-based meta-analysis program for gene expression profiling was used. Both the gene ontology analysis and the pathway enrichment analysis of the differentially expressed genes were conducted. Our results determined that 290 genes were consistently up-regulated in P. gingivalis infected epithelial cells. 229 gene ontology biological process terms of up-regulated genes were discovered, including “negative regulation of apoptotic process” and “positive regulation of cell proliferation/migration/angiogenesis”. In addition to the well-known inflammatory signaling pathways, the pathway associated with a transcriptional misregulation in cancer has also been increased. Our findings indicated that P. gingivalis benefited from the survival of epithelial cells, and got its success as a colonizer in oral epithelium. The results also suggested that infection of P. gingivalis might contribute to oral cancer through chronic inflammation. Negative regulation of the apoptotic process and transcriptional misregulation in cancer pathway are important contributors to the cellular physiology changes during infection development, which have particular relevance to the pathogenesis and progressions of periodontitis, even to the occurrence of oral cancer.
Altering meal timing to improve cognitive performance during simulated nightshifts

ABSTRACT Altering meal timing could improve cognition, alertness, and thus safety during the nightshift. This study investigated the differential impact of consuming a meal, snack, or not eating during the nightshift on cognitive performance (ANZCTR12615001107516). 39 healthy participants (59% male, age mean±SD: 24.5 ± 5.0y) completed a 7-day laboratory study and underwent four simulated nightshifts. Participants were randomly allocated to: Meal at Night (MN; n= 12), Snack at Night (SN; n = 13) or No Eating at Night (NE; n = 14). At 00:30 h, MN consumed a meal and SN consumed a snack (30% and 10% of 24 h energy intake respectively). NE did not eat during the nightshift. Macronutrient intake was constant across conditions. At 20:00 h, 22:30 h, 01:30 h, and 04:00 h, participants completed the 3-min Psychomotor Vigilance Task (PVT-B), 40-min driving simulator, post-drive PVT-B, subjective sleepiness scale, 2-choice Reaction Time task, and Running Memory task. Objective sleep was recorded for each of the day sleeps using Actigraphy and for the third day sleep, Polysomnography was used. Performance was compared between conditions using mixed model analyses. Significant two-way interactions were found. At 04:00 h, SN displayed increased time spent in the safe zone (p < .001; percentage of time spent within 10 km/h of the speed limit and 0.8 m of lane center), and decreases in speed variability (p < .001), lane variability (p < .001), post-drive PVT-B lapses (defined as RT > 355 ms; p < .001), and reaction time on the 2-choice reaction time task (p < .001) and running memory task (p < .001) compared to MN and NE. MN reported greater subjective sleepiness at 04:00 h (p < .001) compared to SN and NE. There was no difference in objective sleep between eating conditions. Eating a large meal during the nightshift impairs cognitive performance and sleepiness above the effects of time of night alone. For improved performance, shiftworkers should opt for a snack at night.
New Perspectives for Modern Trauma Management – Lessons Learned from 25 Years FAST and 15 Years E-FAST

Abstract E-FAST (Extended-Focused Assessment with Sonography for Trauma) is now a widely utilized and internationally recognized standard exam in trauma care. It is highly accepted by emergency physicians and trauma surgeons alike. Thanks to the popularity of PoCUS (point-of-care ultrasound), it has continued to evolve over the last years and can now improve trauma diagnosis at all stages of the primary ABCDE. This review article summarizes key observations made over recent years and also highlights the extension of FAST into E-FAST in the context of PoCUS and CT developments for modern trauma management. Time has come to learn the lessons from 25 years of FAST and 15 years of E-FAST. We should redefine and position ultrasound in the primary ATLS survey (Advanced Trauma Life Support) on two levels: 1. Basic ATLS with new clinical questions, six additional abdominal image sections and one or more follow-up examinations depending on the clinical situation, and 2. Advanced ATLS with ultrasound applications for the entire trauma ABCDE. Zusammenfassung Der E-FAST (Extended-Focused Assessment with Sonography for Trauma) ist heute ein international anerkannter Standard, hoch akzeptiert und hat eine breite Anwendung bei Notfallmedizinern und Trauma-Chirurgen gefunden. Dank der Popularität von PoCUS (Point-of-care-Ultraschall) hat er sich über die letzten Jahre weiterentwickelt und kann die Trauma-Diagnostik auf allen Stufen des primären ABCDE verbessern. Dieses Review fasst die wichtigsten Erkenntnisse der letzten Jahre zusammen und zeigt die Erweiterung und den Stellenwert des E-FAST im Kontext der fokussierten PoCUS- und CT-Bewegung für das moderne Trauma-Management auf. Es ist höchste Zeit, dass wir die Lehren aus 25 Jahren FAST und 15 Jahren E-Komponente ziehen und den Ultraschall in der primären ATLS-Phase (Advanced Trauma Life Support) neu auf 2 Stufen definieren und positionieren: 1. Basisteil mit neuen Fragestellungen, 6 zusätzlichen abdominalen Bildschnitten sowie je nach Situation 1 oder mehrere Verlaufsuntersuchungen und 2. Aufbauteil mit Ultraschallapplikationen für das ganze Trauma-ABCDE.
Efficacy of tocopherol and pentoxifylline combined therapy for women undergoing assisted reproductive treatment with poor endometrial development: a retrospective cohort study on 143 patients

Abstract Poor endometrial development during in vitro fertilization remains challenging. Indeed, no broadly accepted definition of poor endometrial development exists, and no treatment has shown any improvement in the condition. The aim of this study was to analyze whether treatment with a combination of pentoxifylline and tocopherol increases endometrial volume. This monocentric and retrospective study includes patients with previous miscarriages, in vitro fertilization failure, or poor endometrial development. The patients had an ultrasonography during the mid-luteal phase to assess both endometrial thickness and endometrial volume (EV). If the volume was less than 2 mL, they were given pentoxifylline (PTX) and tocopherol for at least 2 months before a second ultrasound assessment. One hundred and forty-four patients were analyzed. The mean duration of treatment was 132 days. The combination of tocopherol and PTX significantly increased the EV by 0.47 mL (p < 0.0001; 95% CI 0.38–0.57). The mean ± SD EV was 1.34 ± 0.38 mL and 1.82 ± 0.63 mL before and after the treatment respectively. No data concerning pregnancy rates were interpretable. We showed an improvement of poor endometrial proliferation with a treatment including PTX and tocopherol. These promising results should be followed up by a prospective study.
Evolution & Development

Funding information Akademie Ved Ceské Republiky, Grant/ Award Number: 67985823; Danish Ministry of Higher Education and Science EliteForsk travel grant; Grantová Agentura Ceské Republiky, Grant/Award Number: 16‐02972S; Czech Ministry of Education, Youth and Sports, Grant/ Award Number: PROGRES Q38 Abstract The atrial septum enables efficient oxygen transport by separating the systemic and pulmonary venous blood returning to the heart. Only in placental mammals will the atrial septum form by the coming‐together of the septum primum and the septum secundum. In up to one of four placental mammals, this complex morphogenesis is incomplete and yields patent foramen ovale. The incidence of incomplete atrial septum is unknown for groups with the septum primum only, such as birds and reptiles. We found a low incidence of incomplete atrial septum in 11 species of bird (0% of specimens) and 13 species of reptiles (3% of specimens). In reptiles, there was a trabecular interface between the atrial septum and the atrial epicardium which was without a clear boundary between left and right atrial cavities. In developing reptiles (four squamates and one crocodylian), the septum primum initiated as a sheet that acquired perforations and the trabecular interface developed late. We conclude that atrial septation from the septum primum only results in a low incidence of incompleteness. In reptiles, the atrial septum and atrial wall develop a trabecular interface, but previous studies on atrial hemodynamics suggest this interface has a very limited capacity for shunting.
The efficacy and safety of elbasvir/grazoprevir treatment in HCV genotype 1 patients in Taiwan

Elbasvir/grazoprevir (EBR/GZR) is a new generation, fixed‐dose, combination antiviral drug used in chronic hepatitis C virus (HCV) genotype (GT) 1 or 4 infection. Our study evaluates the clinical efficacy and safety of EBR/GZR after its launch in Taiwan.
A systematic review of internet-delivered cognitive behavior therapy for alcohol misuse: study characteristics, program content and outcomes

ABSTRACT Alcohol misuse is a common, disabling and costly issue worldwide. Internet-delivered cognitive behavior therapy (ICBT) has the potential to reduce the harms of alcohol misuse, particularly for individuals who are unable or unwilling to access face-to-face therapy. A systematic review was conducted using Medline, CINAHL, EMBASE and PsycINFO databases for all relevant articles published from 1980 to January 2019. Randomized controlled trials (RCTs) were included if (i) an ICBT intervention targeting alcohol misuse was delivered; (ii) participants were aged 18 years or older; and (iii) primary outcomes were quantity of drinking. A qualitative analysis was conducted on the content of the ICBT programs. Fourteen studies met inclusion criteria. Most studies included participants from the general population, while studies conducted within clinic settings with diagnosed individuals were rare. The programs were similar in terms of included modules. Small effects were seen in studies on self-guided ICBT, while therapist-guided ICBT rendered small to large effects. The current review indicates that ICBT has a significant effect in reducing alcohol consumption. Larger studies evaluating ICBT compared to active control groups especially within clinic settings are warranted.