Miracle-dz/UniFAR-FTUs huggingface dataset:
Preventing Falls in Physically Active Community-Dwelling Older People: A Comparison of Two Intervention Techniques

Background: Falls are common in physically active older people; however, most intervention studies have been targeted at frail older people. Objective: To evaluate the effectiveness of two intervention techniques for preventing falls in physically active community-dwelling older people. Methods: Two hundred and seventeen people (120 men and 97 women) aged between 70 and 90 years recruited from a health insurance company membership database were randomly allocated to receive either a psychomotor intervention focusing on body awareness, body experience and coordination, a fitness intervention focusing on functional skills, strength, endurance and flexibility, or no intervention (control group). The outcome measures wereprospective falls (number of fallers, number of multiple fallers, number of falls and falls rate) and measures of physical performance (Timed Up and Go Test, maximal step length, sit-to-stand time, normal and fast walking speed). Results: At the 4-month follow-up, significant improvements in the Timed Up and Go Test and sit-to-stand times were observed for both the psychomotor and fitness intervention groups. During the 12-month follow-up period, 39% of the participants fell at least once, and 19% fell on multiple occasions. The proportion of fallers in the fitness intervention group was 23% less than in the control group (RR = 0.77, 95% CI 0.60–0.97), but no significant reduction in falls was observed in the psychomotor intervention group. Conclusion: A fitness training program improves some aspects of physical performance and reduces falls by 23% in physically active older people.
Use of a liver from donor after cardiac death: is it appropriate for the sick or the stable?

Purpose of reviewLiver transplantation following donation after cardiac death (DCD) continues to be a subject for heated debate. Opinion is divided in the literature as to who benefits the most from receiving a liver from a DCD donor. This review will focus on some important questions regarding the outcome of transplantation and the selection and matching of donor and recipient. Recent findingsLiver transplantation with an organ from a donor after cardiac death is becoming an accepted way to treat patients on the waiting list with end-stage liver disease. However, there are still some major issues to address such as ischemic-type biliary lesions, retransplantation rates, criteria for donor and patient selection and whether conversion of donation after brain death to DCD exists. Accepting a DCD liver has the potential for reduced recipient quality of life after transplant. Death on the waiting list must be balanced against the inherent risks of a DCD liver. SummarySuccess of liver transplantation is mostly measured as graft and patient survival. DCD liver transplantation is a potential tool to decrease mortality on the waiting list. Careful selection and matching of donor organ and recipient can lead to good outcomes. However, ischemic-type biliary lesions after DCD liver transplantation remain an important obstacle to overcome and have a serious impact on quality of life after transplantation.
Constipation in Pregnancy: Prevalence, Symptoms, and Risk Factors

OBJECTIVE: To prospectively estimate constipation prevalence and risk factors in pregnancy. METHODS: We enrolled healthy pregnant women in this longitudinal study during the first trimester. At each trimester and 3 months postpartum, participants completed a self-administered bowel symptom questionnaire, physical activity and dietary fiber intake measures, and a prospective 7-day stool diary. Constipation was defined using the Rome II criteria (presence of at least two of the following symptoms for at least one quarter of defecations: straining, lumpy or hard stools, sensation of incomplete evacuation, sensation of anorectal obstruction, manual maneuvers to facilitate defecation, and fewer than three defecations per week). Generalized linear logistic models explored factors associated with constipation during pregnancy. RESULTS: One hundred three women were enrolled with mean (±standard deviation) age of 28 (±5) years; 54% were nulliparous and 92% white. Constipation prevalence rates were 24% (95% confidence interval [CI] 16–33%), 26% (95% CI 17–38%), 16% (95% CI 8–26%), and 24% (95% CI 13–36%) in the first, second, and third trimesters and 3 months postpartum, respectively. Additionally, irritable bowel syndrome (by Rome II criteria) prevalence rates were 19% (95% CI 12–28%), 13% (95% CI 6–23%), 13% (95% CI 6–23%) and 5% (95% CI 1–13%) in the first, second, and third trimesters and 3 months postpartum, respectively. In multivariable longitudinal analysis, iron supplements (OR 3.5, 95% CI 1.04–12.10) and past constipation treatment (OR 3.58, 95% CI 1.50–8.57) were associated with constipation during pregnancy. CONCLUSION: Constipation measured using the Rome II criteria affects up to one fourth of women throughout pregnancy and at 3 months postpartum. LEVEL OF EVIDENCE: II
Effectiveness of the Surviving the Teens® Suicide Prevention and Depression Awareness Program

Youth suicide is a serious public health issue in the United States. It is currently the third leading cause of death for youth aged 10 to 19. School-based prevention programs may be an effective method of educating youth and enhancing their help-seeking. Most school-based suicide prevention programs have not been rigorously evaluated for their effectiveness. This evaluation employs a comparison group to measure whether program group participants differed significantly from comparison group participants on pretest–posttest measures while assessing the immediate impact of the Surviving the Teens® Suicide Prevention and Depression Awareness Program. Findings indicate several positive outcomes in program group students’ suicide and depression knowledge, attitudes, confidence, and behavioral intentions compared with the comparison group. Suicide prevention specialists and prevention planners may benefit from study findings.
Efficacy and safety of functional electrical stimulation of lower limb muscles in elderly patients with chronic heart failure: A pilot study

Background Exercise training is an established modality in chronic heart failure. Functional electrical stimulation (FES) is an effective alternative mode of training in patients unwilling or unable to exercise; however, it has not been investigated in elderly patients. We sought to investigate the effects of FES on functional status, quality of life, emotional status and endothelial function in chronic heart failure patients aged 70 years or higher. Methods Thirty patients with stable systolic chronic heart failure (mean age 75 ± 3 years, New York Heart Association (NYHA) class II/III, 37%/63%) randomly underwent a six-week FES training programme or placebo. Questionnaires addressing quality of life (Kansas City Cardiomyopathy Questionnaire (KCCQ), functional and overall) and emotional stress (Zung self-rating depression scale (SDS), Beck Depression Inventory (BDI)), as well as endothelial function (flow-mediated dilatation) were assessed at baseline and upon protocol completion. Results A significant improvement in NYHA class (p = 0.005), KCCQ-functional (F = 68.6, p for interaction < 0.001), KCCQ-overall (F = 66.9, p < 0.001), BDI (F = 66.3, p < 0.001) and Zung SDS (F = 95.1, p < 0.001) was observed in the FES group compared to placebo. Patients in the FES group also had a significant increase in flow-mediated dilatation compared with placebo (F = 59.1, p < 0.01). FES-induced per cent change in flow-mediated dilatation was significantly correlated with respective per cent change in KCCQ functional (r = 0.386, p = 0.039). Conclusion In this pilot study, FES effectively improved functional status, quality of life, motional stress and endothelial function in elderly chronic heart failure patients and warrants further investigation in this particular group of patients.
Value of EUS in early detection of pancreatic ductal adenocarcinomas in patients with intraductal papillary mucinous neoplasms

Background and study aims: Pancreatic ductal adenocarcinomas (PDAC) sometimes arise in patients with intraductal papillary mucinous neoplasms (IPMNs). This study examined the incidence of PDACs concomitant to or derived from branch duct IPMNs. The usefulness of endoscopic ultrasonography (EUS) relative to other imaging methods for detecting these tumors was also assessed. Patients and methods: This retrospective study used data from clinical records and imaging studies that were collected prospectively. During 2001 – 2009, 167 consecutive patients with IPMNs underwent EUS, ultrasonography, computed tomography (CT), and magnetic resonance imaging (MRI). The 102 patients whose branch duct IPMNs lacked mural nodules/symptoms and thus did not qualify for resection were followed up by semiannual EUS and annual ultrasonography, CT, and MRI. The sensitivity and specificity with which the four modalities detected IPMN-derived and -concomitant PDACs at the first examination and throughout the study period were evaluated. The rate of PDAC development during follow-up was analyzed by the Kaplan–Meier method. Results: A total of 17 IPMN-derived and 11 IPMN-concomitant PDACs were diagnosed at the first examination. Lesions that did not qualify for resection or chemotherapy were followed up for a median of 42 months. Seven IPMN-concomitant PDACs and no IPMN-derived PDACs were detected during follow-up. The 3- and 5-year rates of IPMN-concomitant PDAC development were 4.0 % and 8.8 %, respectively. At the first examination, EUS was superior to other imaging modalities in terms of IPMN-derived and -concomitant PDAC detection. Throughout the study period, including follow-up, EUS was significantly better at detecting IPMN-concomitant PDACs than the other modalities. Conclusions: IPMN-concomitant PDACs are quite often found at diagnosis and during follow-up. EUS examination of the whole pancreas plays an important role in the management of IPMNs as it allows the early detection of these small invasive carcinomas.
Autologous bone marrow transplantation for patients with non-Hodgkin's lymphoma and CNS involvement: those transplanted with active CNS disease have a poor outcome--a report by the European Bone Marrow Transplant Lymphoma Registry.

PURPOSE CNS involvement of non-Hodgkin's lymphoma (NHL) has always been considered a poor prognostic factor in relation to survival with conventional therapy. However, its effect on the outcome of autologous bone marrow transplantation (ABMT) has not been assessed. We examined this using data from the European Bone Marrow Transplant (EBMT) Lymphoma Registry. PATIENTS AND METHODS One thousand four hundred sixty-four patients with NHL have been reported to the EBMT registry, of whom 62 had CNS involvement. Patients were divided into those who were clear of CNS disease at the time of ABMT and those who were not. Response, complications, and outcome to ABMT were analyzed, as were details of CNS diagnosis, treatment, and prophylaxis. RESULTS Status at transplant was the only factor that significantly affected outcome of ABMT on univariate analysis (P = .03). The progression-free survival (PFS) rate of the group that had no CNS involvement at ABMT was 42% at 5 years, compared with 27% in a group of stage IV NHL patients without CNS disease (matched for status at transplant and histology). There were four of 45 (8.9%) toxic deaths. The PFS rate of the group that had CNS involvement at ABMT was 9% at a median follow-up time of 71 months, which was significantly different (P = .001) from that of the other group. There were five of 17 (29.4%) toxic deaths (P = .043). Patients who had CNS involvement at diagnosis, as compared with relapse, and those treated with both intrathecal chemotherapy and irradiation had a better outcome. CONCLUSION The presence of CNS disease before ABMT but not present at transplant does not adversely affect the outcome of ABMT. In contrast, patients with CNS involvement at the time of ABMT have a poor prognosis, although a small number survive in complete remission (CR).
Head position for facilitating the superior vena caval placement of catheters during right subclavian approach in children

Objective To evaluate the effect of head position as a method to facilitate the superior vena caval placement of catheters during right subclavian catheterization in children. Design Prospective, randomized, clinical trial. Setting Department of anesthesiology, university hospital. Patients One hundred sixty-eight pediatric patients, aged <8 yrs, undergoing simple cardiac surgery or pediatric general surgery. Interventions At operation, the patients were assigned by the stratified randomization for age to one of the four groups (n = 42 each): when the patients turned their heads away from the puncture side, this was away-turning group; when turned toward the puncture side, toward-turning group; when lateral-flexed (tilted) away from the puncture side, away-lateral-flexion group; and when lateral-flexed toward the puncture side, toward-lateral-flexion group. Each group was divided into two subgroups depending on the age: infant (n = 24 each) and young children (>12 months; n = 18 each). Measurements and Main Results Right infraclavicular subclavian catheterization, using the Seldinger technique, was attempted. After catheterization, a simple chest radiograph was used to identify the location of catheter tip. There was no difference in age and body weight between the groups. Only in infants was the successful placement rate of toward-lateral-flexion group (92%) higher than that of the other three groups (54% [away-lateral-flexion], 63% [away-turning], or 54% [toward-turning]), and there was no difference among the others. Conclusion In infants, tilting the head toward the catheterization side can reduce the incidence of catheter malposition during the right subclavian approach.
Low prevalence of human papillomavirus infection of the cervix in renal transplant recipients.

BACKGROUND An increased risk of anogenital tract malignancies has been noted among renal transplant recipients. A high prevalence of human papillomavirus (HPV) infection of the cervix in the female renal-transplant population has been assumed based on increasing evidence suggesting that HPV infection is the major risk factor for cervical intraepithelial neoplasia (CIN) and cervical cancer. It has been assumed that immunosuppression leads to either a reactivation of latent HPV or a reduction in the host's ability to contain a primary HPV infection, thereby increasing the risk of CIN and cervical cancer. The objective of this study was to evaluate the prevalence of human papillomavirus (HPV) infection in a population of iatrogenically immunosuppressed renal transplant recipients. METHODS Twenty-one women were recruited from the renal transplant clinic at Presbyterian Hospital and underwent a gynaecological examination which included colposcopy, a Papanicolaou smear, and a cervicovaginal lavage. Lavage samples were analysed for HPV DNA using L1 consensus primers and the polymerase chain reaction (PCR). RESULTS No cases of cervical intraepithelial neoplasia (CIN) were detected in this cohort of 21 immuno-suppressed renal transplant recipients. HPV DNA was detected in only a single patient. CONCLUSIONS Our data suggests that HPV infection is not highly prevalent among older, cytologically normal renal transplant recipients, particularly those who are currently monogamous or not presently sexually active. This study suggests that recent sexual behaviours are more important than past behaviours as a determinant of HPV status in transplant recipients, and also suggests that education concerning the avoidance of high-risk sexual behaviour is an important part of the care of the female renal transplant recipient. Our data is consistent with previous work suggesting that the incidence of CIN is declining in transplant recipients, and it also suggests that the prevalence of HPV infection may be declining as well.
Help Seeking for Mental Health on College Campuses: Review of Evidence and Next Steps for Research and Practice

&NA; This article reviews what is known about help‐seeking behavior for mental health problems in college populations and offers suggestions for the next steps that could be undertaken to improve knowledge and practice in this area. Our review suggests that traditional barriers, such as stigma, can only partially explain the high prevalence of untreated disorders. We discuss the conclusions and limitations of research on campus‐based intervention strategies, including anti‐stigma campaigns, screening programs, and gatekeeper trainings. In proposing new directions for research and practice, we consider insights from research on other health behaviors (e.g., diet and exercise) as well as innovative ideas from behavioral economics and cognitive psychology regarding behavior change.
Morphological characteristics of Street Workout practitioners.

INTRODUCTION The determination of the morphological characteristics of the most popular sports has allowed the evaluation and comparison between athletes, which has helped to improve their performance. The Street Workout is an emerging sport based on calisthenics, which recently has become popular. Despite its popularization, neither the morphologic profile nor the morphologic characteristics of Street Workout athletes has been determined. OBJECTIVE Determine the profile and morphological characteristics of Street-Workout athletes, through anthropometry. MATERIAL AND METHODS Fourteen athletes (22.7 ± 3.26 years) were recruited from the National Calisthenics Tournament 2015 in Chile. The athletes were evaluated following the protocol of the International Society for the Advancement of Kinanthropometry to determine the somatotype, body composition, as well as indices of body composition such as body mass index, waist to hip ratio, waist to height ratio, fat/muscle mass and muscle/bone mass indexes. RESULTS Street Workout practitioners presented a balanced-mesomorphic somatotype, a low fat mass and a high muscular development, with upper arms and trunk predominance. Regarding body composition indices, the values obtained allow us to classify them as a low-risk population of chronic non-communicable diseases. CONCLUSION The present study sets a first antecedent of the morphological characteristics of Street Workout, determining that the Street Workout athletes presented balanced-mesomorphic somatotype and were classified as a healthy and athletic sample by their body composition indexes.
Differentiation of human endometrial stem cells into urothelial cells on a three‐dimensional nanofibrous silk–collagen scaffold: an autologous cell resource for reconstruction of the urinary bladder wall

Reconstruction of the bladder wall via in vitro differentiated stem cells on an appropriate scaffold could be used in such conditions as cancer and neurogenic urinary bladder. This study aimed to examine the potential of human endometrial stem cells (EnSCs) to form urinary bladder epithelial cells (urothelium) on nanofibrous silk–collagen scaffolds, for construction of the urinary bladder wall. After passage 4, EnSCs were induced by keratinocyte growth factor (KGF) and epidermal growth factor (EGF) and seeded on electrospun collagen‐V, silk and silk–collagen nanofibres. Later we tested urothelium‐specific genes and proteins (uroplakin‐Ia, uroplakin‐Ib, uroplakin‐II, uroplakin‐III and cytokeratin 20) by immunocytochemistry, RT–PCR and western blot analyses. Scanning electron microscopy (SEM) and histology were used to detect cell–matrix interactions. DMEM/F12 supplemented by KGF and EGF induced EnSCs to express urothelial cell‐specific genes and proteins. Either collagen, silk or silk–collagen scaffolds promoted cell proliferation. The nanofibrous silk–collagen scaffolds provided a three‐dimensional (3D) structure to maximize cell‐matrix penetration and increase differentiation of the EnSCs. Human EnSCs seeded on 3D nanofibrous silk–collagen scaffolds and differentiated to urothelial cells provide a suitable source for potential use in bladder wall reconstruction in women. Copyright © 2013 John Wiley & Sons, Ltd.
Comparison of histologic spinal cord and neurologic changes in guinea pigs after subarachnoid block with large volumes of racemic bupivacaine, 50% enantiomeric excess bupivacaine (S75-R25), and levobupivacaine.

BACKGROUND AND OBJECTIVES Levobupivacaine has less central nervous system side effects than racemic bupivacaine, but its anesthetic effect is not as intense. The objective of this experimental study was to compare the adverse effects of large volumes of bupivacaine, S75-R25 bupivacaine, and levobupivacaine injected in the subarachnoid space of guinea pigs. METHODS Forty guinea pigs were divided in four groups. They were anesthetized with 100% O2 and 2% isoflurane, followed by puncture of the L6-S1 intervertebral space. In Group 1, 2 mL of normal saline were injected; in Group II, 2 mL of 0.5% bupivacaine; in Group III, 2 mL of 0.5% S75-R25 bupivacaine, and in Group IV, 2 mL of 0.5% levobupivacaine. After the animal awakened, neurological exam was done at 0, 60, 120, and 180 minutes, and daily for one week. Animals were killed and underwent perfusion with 4% paraformaldehyde. After fixation, the spinal cord was isolated by dissection and analyzed histologically to evaluate the degree of spinal cord lesions. RESULTS Guinea pigs in the control group did not present nervous block. Those in Group II presented sensitive and motor block for more than 180 minutes. Animals in Groups III (S75-R25) and IV (levobupivacaine) developed sensitive and motor blockade at moment 0, but at 60 minutes the motor blockade was minimal. Histologic exam in Group I showed no changes. In Group II, severe spinal cord changes were observed. In Groups III and IV, spinal cord changes were mild. CONCLUSIONS Large volumes of levobupivacaine caused little damage in the central nervous system when compared with bupivacaine. Statistically significant changes were not observed between levobupivacaine and S75-R25 bupivacaine.
Feedback-Based Debugging

Software debugging has long been regarded as a time and effort consuming task. In the process of debugging, developers usually need to manually inspect many program steps to see whether they deviate from their intended behaviors. Given that intended behaviors usually exist nowhere but in human mind, the automation of debugging turns out to be extremely hard, if not impossible. In this work, we propose a feedback-based debugging approach, which (1) builds on light-weight human feedbacks on a buggy program and (2) regards the feedbacks as partial program specification to infer suspicious steps of the buggy execution. Given a buggy program, we record its execution trace and allow developers to provide light-weight feedback on trace steps. Based on the feedbacks, we recommend suspicious steps on the trace. Moreover, our approach can further learn and approximate bug-free paths, which helps reduce required feedbacks to expedite the debugging process. We conduct an experiment to evaluate our approach with simulated feedbacks on 3409 mutated bugs across 3 open source projects. The results show that our feedback-based approach can detect 92.8% of the bugs and 65% of the detected bugs require less than 20 feedbacks. In addition, we implement our proof-of-concept tool, Microbat, and conduct a user study involving 16 participants on 3 debugging tasks. The results show that, compared to the participants using the baseline tool, Whyline, the ones using Microbat can spend on average 55.8% less time to locate the bugs.