Miracle-dz/UniFAR-FTUs huggingface dataset:
Syddansk Universitet Improved outcome in acute myeloid leukemia patients enrolled in clinical trials A national population-based cohort study of Danish intensive chemotherapy patients Østgård,

Clinical trials are critical to improve AML treatment. It remains, however, unclear if clinical trial participation per se affects prognosis and to what extent the patients selected for trials differ from those of patients receiving intensive therapy off-trial. We conducted a population-based cohort study of newly diagnosed Danish AML patients treated with intensive chemotherapy between 2000–2013. We estimated accrual rates and compared characteristics, complete remission (CR) rates, and relative risks (RRs) of death at 90-day, 1-year, and 3-years in clinical trial patients to patients treated off-trial. Of 867 patients, 58.3% (n = 504) were included in a clinical trial. Accrual rates were similar across age groups (p = 0.55). Patients with poor performance status, comorbidity, therapy-related and secondary AML were less likely to be enrolled in trials. CR rates were 80.2% in trial-patients versus 68.6% in patients treated offtrial. Also, trial-patients had superior survival at 1-year; 72%, vs. 54% (adjusted RR of death 1.28(CI = 1.06–1.54)), and at 3 years; 45% vs. 29% (adjusted RR 1.14(CI = 1.03–1.26)) compared to patients treated off-trial. Despite high accrual rates, patients enrolled in clinical trials had a favorable prognostic profile and a better survival than patients treated off-trial. In conclusion, all trial results should be extrapolated with caution and population-based studies of “real world patients” have a prominent role in examining the prognosis of AML.
THE EFFECT OF EXCHANGE RATES ON EXPORTS AND IMPORTS OF EMERGING COUNTRIES

The debate regarding the desirable degree of foreign exchange rate policies hasbeen persisting for decades. Markets are able to effectively achieve optimum efficacy and maximize welfare output when operated without distortions. This research was guided by two key objectives;to determine the impact of exchange rates on imports and to investigate the impact of exchange rates on exports of economically developing countries. This paper focusses on establishing whether there is a co-integrated relationship between effective exchange rates of selected emerging countries. Many studies have indicated that policies touching on exchange rates closely affect the international trade of a country. This study applies the panel cointegration method for the period of 1985-2012. The annual data used in the empirical analysis were obtained from the World Bank data base. As a result, there is cointegrated relationshipbetween effective exchange rates and exports-imports of emerging countriesin the long run.
Patent Quality and Research Productivity: Measuring Innovation with Multiple Indicators

We analyse the determinants of the decline in research productivity using panel data on manufacturing firms in the US for the period 1980-93. We focus on three factors: the level of demand, the quality of patents and technological exhaustion. We develop an index of patent 'quality' using detailed patent information and show that using multiple indicators substantially reduces the measured variance in quality. Research productivity at the firm level is inversely related to patent quality and the level of demand, as predicted by theory and patent quality is positively associated with the stock market value of firms. Copyright 2004 Royal Economic Society.
Characteristics of IEF Patterns and SDS-PAGE Results of Korean EPO Biosimilars

Erythropoietin (EPO) is mainly produced in kidney and stimulates erythropoiesis. The use of recombinant EPOs for doping is prohibited because of its performance enhancing effect. This study investigated whether biosimilar EPOs could be differentiated from endogenous one by iso-electro-focusing plus double blotting and SDS-PAGE for anti- doping analysis. The established method was validated with positive control urine. The band patterns were reproducible and meet the criteria, which was made by world anti doping agency (WADA). Isoelectric focusing was conducted in pH range 2 to 6. Recormon (La Roche), Aropotin (Kunwha), Epokine (CJ Pharm Co.), Eporon (Dong-A), Espogen (LG Life Sciences), and Dynepo (Shire Pharmaceuticals) were detected in basic region. All biosimilars showed discriminative isoelectric profiles from endogenous EPO profiles, but they showed different band patterns with the reference one except Epokine (CJ Pharm Co.). Next, SDS-PAGE of biosimilar EPOs resulted in different molecular weight patterns which were distributed higher than endogenous EPO. Commercial immune assay kit as an immune affinity purification tool and immobilized antibody coated magnetic bead were tested for the purification and con- centration of EPO from urinary matrix. The antibody-coated magnetic bead gave better purification yield. The IEF plus double blotting and SDS-PAGE with immunoaffinity purification method established can be used to discriminate biosimilar EPOs from endogenous EPO.
Evaluation of the Processing Technologies of Cassava Chips and Flour in Oyo and Ogun States of Nigeria

A survey was conducted between January and August in the year to evaluate the processing technologies of cassava chips and flour in Oyo and Ogun States. About (37.5%) obtain their raw materials from their own farms and farm gate while 62.5% was from market purchase. Higher percentage of processors (80.95%) obtain their capital from personal savings. Cassava flour was the most popular (70%). Semi-modern method of processing (76.19%) was the most popular in comparison to other materials. Greater percentage (80.95%) for whole sale while most of the processors are married (85.7%). Also, most of their enterprise are located residencially.
Strategic Experimentation with Poisson Bandits

This paper studies a game of strategic experimentation with two-armed bandits where the risky arm distributes lump-sum payoffs according to a Poisson process. The intensity of this process is either high or low, and unknown to the players. We consider Markov perfect equilibria with beliefs as the state variable. There is no equilibrium where all players use cut-off strategies, and all equilibria exhibit an `encouragement effect' relative to the single-agent optimum. The fact that a success on the risky arm is not fully revealing limits the payoff asymmetry as well as the inefficiency of asymmetric equilibria. We construct the unique symmetric MPE and, for a sufficiently high difference between the two possible intensities, an asymmetric equilibrium that dominates the symmetric one in terms of aggregate payoffs.
Investigation into the performance of physical developer formulations for visualizing latent fingerprints on paper

Latent fingerprints deposited on commercial photocopy paper were treated using various preparations of silver-based physical developer and the results from each were compared to those obtained with the standard formulation used by the Australian Federal Police. Five redox stock solutions were prepared with altered orders of reagent addition, and a further solution prepared with exchanged iron concen- trations, to test the robustness of the method. Three redox solutions were prepared with specific reagents omitted to determine the signifi- cance of the role played by each in development. One redox solution was prepared using Tween 20 as the non-ionic surfactant to assess its suitability as a replacement for Synperonic N. An acid prewash was also prepared using malic acid as an alternative to maleic acid. Results showed the method to be robust to alterations in reagent addition, but not to significant concentration changes. The presence of all compo- nents was found to be desirable for distinguishable development of fingerprint detail. It was additionally found that Tween 20 gave at least equal performance to Synperonic N on recently deposited fingerprints. Finally, the use of malic acid gave equivalent fingerprint development but higher background in comparison to maleic acid.
The Food Processing Industry, Globalization and Developing Countries

Transformations in the food processing sectors of developing countries are increasingly seen as strategic from the point of view of export earnings, domestic industry restructuring and dietary issues. This article reviews a selection of the literature on these themes. It begins with a discussion of the main trends identifiable in the food processing industries of the three regional blocs of the developed world, since it is their combined impact that determines the complex patterns of globalization. There follows a discussion of the importance of non-traditional food processing exports by developing countries and the different interpretations to which it has given rise. The internal transformations of the food processing sector of developing countries under the combined impact of imports and FDI are then considered. We conclude with a discussion of the heterogeneous dynamic of food processing in developing countries and the different possibilities for strengthening the participation of small and medium enterprises.
Numerical Simulation of Radiolysis Gas Detonations in a BWR Exhaust Pipe and Mechanical Response of the Piping to the Detonation Pressure Loads

Radiolysis gas (2H2+O2) can accumulate in steam piping of Boiling Water Nuclear Reactor (BWR) in case of steam condensation. A detonation of radiolysis gas was the likeliest cause of the pipe ruptures in the Hamaoka-1 and Brunsbuttel accidents (Nakagami, 2002; Schulz et al., 2002). In both cases the failed pipes were initially under the operating pressure of 70 bar. During the detonation accident the pressure rose up to 1000 bar or more. In the current paper we consider a typical BWR exhaust pipe and first evaluate the maximum pressure load in case of a radiolysis gas detonation at an initial pressure of 1.6 bar and a temperature of 35 °C. Next, the mechanical response of the exhaust pipe and its possible damage will be numerically evaluated. The typical exhaust pipe investigated in this study is shown in Fig. 1. It consists of two parts with an outer diameter of 510 and 419 mm fabricated from stainless steel DIN 1.4541. In reality, the exhaust pipe is filled with nitrogen initially. Radiolysis gas (RG) with steam can enter through an exhaust valve due to an opening procedure or due to a leak. In case of a slow long time steam condensation, the radiolysis gas can accumulate at the top of the exhaust pipe. Thus, without an additional ventilation, the “worst case” atmosphere in the exhaust pipe has an initial pressure of 1.6 bar (controlled by the 6 m height of the water level) and consists of radiolysis gas diluted with nitrogen. According to the recommendations of the Reactor Safety Commission (Germany) for radiolysis gas control in BWR plants it is demanded to determine the reaction pressure for the highest radiolysis gas concentration which could arise. Our previous data analysis (Kuznetsov et al., 2007a) was based on the postulated detonation of pure radiolysis gas, consisting of a stoichiometric hydrogen-oxygen mixture, as the “worst case” scenario. In this study three levels of pressure loads for “worst case” conditions were evaluated in these works: (1) the stationary detonation pressure of about 29 bar; (2) the local deflagration-todetonation transition (DDT) pressure of 62.5 bar; and (3) the reflected Chapman-Jouguet (CJ) pressure of 71 bar as the maximum detonation pressure that occurs at the tube end. The characteristic pressure loading time was estimated to be about 2 ms, which corresponds to the quasi-static loading regime for a tube of 510 mm outer diameter and 15 mm of wall
Experimental Study on Effect of Sediment Size on River Dyke Breach Characteristics Due to Overtopping

Flood discharge induced overtopping flow through the river dyke cause large destruction on the environment, infrastructure and the countryside every year in the world. The failure by overtopping constitutes the primary failure modes of earth embankment besides internal erosion. There were a lot of researches conducted to understood embankment dam failure and few for the river dyke breach, but the lateral widening of breach process and the time of failure prediction is poorly understood. The breaching process of a river dyke is very complex because of manifold interactions between water, soil and structure. Enlargement dynamics and final breach geometry are also the result of boundary and initial conditions affecting the dyke Therefore, Preliminary Laboratory tests were conducted to investigate the dynamic lateral widening process and breach characteristics. The whole process was recorded optically using video and threedimensional camera for the detail analysis of the breaching phenomena. The result indicates the important effect of sediment size on the dynamic lateral widening process, breach discharge and the time of failure. A systematic variation of the sediment size reveals important findings regarding breach characteristics. Finally the curve for the time of failure is also proposed which requires testing with future experiments. The final experiment with new experimental setup considering actual parallel flow through the dyke is conducting now with the lesson learnt from this experiment.
The role of maternal emotional cognitive strategies and newborn gender satisfaction in the postpartum depression in the primiparous women

Background: The Postpartum depression has a negative effect on the infant’s developmental and behavioral performance, mother-child relationship and mother‘s health, and its etiology is also very complicated. Objectives: This study was conducted to investigate the role of maternal emotional cognitive strategies and newborn gender preference in the postpartum depression in primiparous women. Methods: This descriptive-correlational study was performed on 205 primiparous women referring to health centers in Kerman city the center of Kerman province of Iran from 1April to 31 June 2015. Primiparous women according to presence (n=103) or absence (n=102) of postpartum depression (PPD< 12: without depression) were selected using purposeful sampling. The measurement tools included the demographic questionnaire, Edinburgh postpartum Depression Scale (EPDS) and Cognitive Emotion Regulation Questionnaire (CERQ). The data were analyzed using SPSS software and the logistic regression method. Results : The results showed positive cognitive strategies including acceptance, positive re-focus and refocus on planning have a negative relationship with the postpartum depression (P<0.001). Also, the strategies of self-blame, catastrophizing, rumination and blame for others have a positive relationship with the postpartum depression (P<0.001). There was no significant relationship between dissatisfaction with newborn gender and postpartum depression (P>0.05). Conclusion: According to the results of this study, postpartum depression can be predicted by emotional regulation cognitive strategies.
The Effect of Recapitalization on Bank Performance in Nigeria

This study evaluates the effect of mergers and acquisitions on bank recapitalization inNigeriawith emphasis on the impact of the strategy on economy development. The study makes use of data from the foremost eight banks inNigeriathat account for over 60% of the banking transaction in the country. The research work was evaluated through regression analysis of secondary data covering ten years (2002-2011) from the sampled banks. The research entails a study of the pre-recapitalization and post-recapitalization periods hence the sample period was divided into two. This approach assists to capture the actual effect of the latest recapitalization policy of the government during the period. The result suggests that the effect of the latest recapitalization policy was positive on the operational capability of theNigeriabanking system. There are lot of economies of scale derived from the exercise. Harnessing of resources through mergers and acquisition gave the banks the much required funds to intermediate more effectively within the financial system.
Identification of aroma compounds of Vitis vinifera L. flowers by SPME GC-MS analysis

Using a gas chromatographic method (GC-MSanalysis), it was possible to determine the volatile constituent of an odorous flower from Vitis vinifera varieties growing in Sicily. More than 50 compounds were identified and the technique allowed us to determine that sesquiterpenes, as well as monoterpenes such as limonene and cymene, were the principal components. The odour-profiles allowed us to distinguish between variety groups or even single varieties.
AC 2012-4200: ESSENTIAL FACTORS RELATED TO ENTREPRENEURIAL KNOWLEDGE IN THE ENGINEERING CURRICULUM

Mary Besterfield-Sacre is an Associate Professor and Fulton C. Noss Faculty Fellow in Industrial Engineering. She is the Director for the new Engineering Education Research Center (EERC) in the Swanson School of Engineering, and serves as a Center Associate for the Learning Research and Development Center at the University of Pittsburgh. Her principal research is in engineering assessment, which has been funded by the NSF, Department of Education, Sloan Foundation, Engineering Information Foundation, and the NCIIA. Besterfield-Sacre’s current research focuses on three distinct but highly correlated areas of innovative design, entrepreneurship, and modeling. She is an Associate Editor for the AEE Journal.
Reanalysis of multi-temporal aerial images of Storglaciären, Sweden (1959–99) – Part 2: Comparison of glaciological and volumetric mass balances

Seasonal glaciological mass balances have been measured on Storglaciwithout interruption since 1945/46. In addition, aerial surveys have been carried out on a decadal basis since the beginning of the observation pro- gram. Early studies had used the resulting aerial photographs to produce topographic glacier maps with which the in-situ observations could be verified. However, these maps as well as the derived volume changes are subject to errors which resulted in major differences between the derived volumet- ric and the glaciological mass balance. As a consequence, the original photographs were re-processed using uniform photogrammetric methods, which resulted in new volumetric mass balances for 1959-69, 1969-80, 1980-90, and 1990- 99. We compared these new volumetric mass balances with mass balances obtained by standard glaciological methods including an uncertainty assessment considering all related previous studies. The absolute differences between volumet- ric and the glaciological mass balances are 0.8 m w.e. for the period of 1959-69 and 0.3 m w.e. or less for the other survey periods. These deviations are slightly reduced when consid- ering corrections for systematic uncertainties due to differ- ences in survey dates, reference areas, and internal ablation, whereas internal accumulation systematically increases the mismatch. However, the mean annual differences between glaciological and volumetric mass balance are less than the uncertainty of the in-situ stake reading and stochastic error bars of both data series overlap. Hence, no adjustment of the glaciological data series to the volumetric one is required.
Sequestration and turnover of bacterial‐ and fungal‐derived carbon in a temperate grassland soil under long‐term elevated atmospheric pCO2

Temperate grasslands contribute about 20% to the global C budget. Elevation of atmospheric CO2 concentration (pCO2) could lead to additional C sequestration into these ecosystems. Microbial‐derived C in the soil comprising about 1–5% of total soil organic carbon may be an important ‘pool’ for long‐term storage of C under future increased atmospheric CO2 concentrations. In our study, the impact of elevated pCO2 on bacterial‐ and fungal‐derived C in the soil of Lolium perenne pastures was investigated under free air carbon dioxide enrichment (FACE) conditions. For 7 years, L. perenne swards were exposed to ambient and elevated pCO2 (36 and 60 Pa pCO2, respectively). The additional CO2 in the FACE plots was depleted in 13C compared with ambient plots, so that ‘new’ (<7 years) C inputs in the form of microbial‐derived residues could be determined by means of stable C isotope analysis. Amino sugars in soil are reliable organic biomarkers for indicating the presence of microbial‐derived residues, with particular amino sugars indicative of either bacterial or fungal origin. It is assumed that amino sugars are stabilized to a significant extent in soil, and so may play an important role in long‐term C storage. In our study, we were also able to discriminate between ‘old’ (> 7 years) and ‘new’ microbial‐derived C using compound‐specific δ13C analysis of individual amino sugars. This new tool was very useful in investigating the potential for C storage in microbial‐derived residues and the turnover of this C in soil under increased atmospheric pCO2.
The role of management accounting in family business succession

Family business succession is considered inherent to family businesses and represents a critical process that is generally characterised by resistance to change. This study aims to investigate the role of management accounting systems (MASs) in family business succession, in order to understand how changes in MASs during the succession across different family generations can help the succession process itself, facilitating the rise of the new leader, supporting changes, and reducing resistance to them. The research adopts a case study approach, focusing on organizational routines and their changes, at the same time taking into account the socioemotional wealth of the family firm. Evidence from the study shows the strategic role of MAS in managing the succession process, through the implementation of new routines and rules in helping the decision-making process and in achieving the firm’s leadership. Key words: Family business succession, management accounting changes, routines, socioemotional wealth.
A new method for 3-D magnetic data inversion with physical bound

Inversion of magnetic data is an important step towards interpretation of the practical data. Smooth inversion is a common technique for the inversion of data. Physical bound constraint can improve the solution to the magnetic inverse problem. However, how to introduce the bound constraint into the inversion procedure is important. Imposing bound constraint makes the magnetic data inversion a non-linear inverse problem. In this work, a new algorithm is developed for the 3D inversion of magnetic data, which uses an efficient penalization function for imposing the bound constraint and Gauss Newton method to achieve the solution. An adaptive regularization method is used in order to choose the regularization parameter in this inversion approach. The inversion results of synthetic data show that the new method can produce models that adequately match the real location and shape of the synthetic bodies. The test carried out on the field data from Mt. Milligan copper-gold porphyry deposit shows that the new inversion approach can produce the magnetic susceptibility models consistent with the true structures.
Paleoenvironmental interpretation of late Quaternary molluscan assemblages from southern South América: A taphonomic comparison between the Strait of Magellan and the Beagle Channel.

Este trabajo analiza los ensambles de moluscos del Holoceno de las terrazas marinas presentes a lo largo de las costas del Estrecho de Magallanes y del Canal Beagle. Un total de 33 especies de gastropodos y 12 de bivalvos fueron identificados. Ellos constituyen un primer listado de moluscos para los depositos del Estrecho de Magallanes. El analisis tafonomico sugiere un ambiente de alta energia con elementos epifaunales en el Estrecho de Magallanes y un ambiente de baja energia con el predominio de elementos infaunales para el Canal Beagle. Todas las especies colectadas son taxa vivientes, lo que sugiere que las variaciones climaticas postglaciales no fueron suficientes para alterar la composicion de las comunidades desde al menos 6.000 anos AP en el extremo austral de Chile-Argentina.