Miracle-dz/UniFAR-FTUs huggingface dataset:
Commonalities in Effective Behavioral Interventions for Children and Adolescents With Type 1 Diabetes: A Review of Reviews

A major public health trend of the 1990s was to focus on health status and health-related quality of life outcomes.1,2 Work in the field of diabetes treatment and research during this time provided examples of this focus,3 and much research has benefited, both directly and indirectly, from many of these earlier studies.4–6 It is in the spirit of this focus on health status and quality of life, along with these earlier studies, that many current efforts to examine, understand, and refine interventions aimed at promoting physical and psychological health outcomes are conducted. Pediatric diabetes is no exception, with at least three comprehensive reports being published since 2000 on the effectiveness of behaviorally oriented interventions to optimize health outcomes in children and adolescents with type 1 diabetes.7–9 Hampson et al.7 conducted a meta-analysis to determine which behavioral interventions were effective in promoting psychosocial, metabolic, self-management, and diabetes knowledge outcomes. Their statistically rigorous approach highlighted certain treatments, particularly those with a theoretical foundation, that offered greater promise in terms of psychological and physiological outcomes.10–12 Further, they were able to provide a quantitative examination of the public health impact of these interventions through use of the RE-AIM framework.13 However, their overarching conclusion about behavioral interventions for adolescents with type 1 diabetes was that they offered small to medium beneficial effects across these outcomes. Northam et al.8provided a comprehensive review of the literature on behavioral interventions for children and adolescents with type 1 diabetes across psychological and metabolic outcomes. They noted that most interventions contained some aspect of psycho-educational or cognitive-behavioral techniques ultimately aimed at promoting behavior change related to diabetes management. However, most used nonstandardized, study-specific interventions that involved multiple components, making it difficult to draw …
Assessing the Impact of School-Based Greenness on Mental Health Among Adolescent Students in Ontario, Canada

Neighbourhood greenness has been frequently associated with improved mental health in adulthood, yet its impact among youth is less clear. Additionally, though youth spend large portions of time at school, no study has investigated associations between school-based measures of greenness and students’ mental health in Canada. We addressed this gap by linking participant responses from the 2016–2017 Ontario Student Drug Use and Health Survey to school-based features of the built environment. Our analyses included 6313 students, ages 11–20. Measures of greenness were the mean and max of the annual mean Normalized Difference Vegetation Index within 500 m and 1000 m from the centroid of the school postal code. Measures of mental health included: serious psychological distress (Kessler 6-item Psychological Distress Scale), self-rated mental health (using a five-point Likert scale), suicide ideation, and suicide attempt. In our study population, the prevalence of serious psychological distress and low self-rated mental health was 16.7% and 20.3%, respectively. Suicide ideation was reported by 13.5% of participants, while 3.7% reported a suicide attempt. Quantity of greenness was similar between schools in the lower and upper quartiles. In logistic regressions, we found no association between objective school-based greenness and mental health, as assessed by multiple measures, both before and after adjustment. Null findings held true after stratification by season, as well. Whether other characteristics of school greenness (such as type, quality, or access and use) are more impactful to students’ mental health should be a focus of future analyses.
A Study of Mental Health Counselors' Use of and Perspectives on Distance Counseling

Using a survey measuring 21 factors proposed in recent literature to be advantages or disadvantages of distance counseling, with a sample of 854 mental health professionals, we investigated perceptions and use of counseling by telephone, e-mail, text chat, and videoconference. Most participants reported using distance counseling in some form, but they perceived more disadvantages than advantages. Recommendations are provided for professionals considering the practice of distance counseling.
APOE is a correlate of phenotypic heterogeneity in Alzheimer disease in a national cohort

Objective To compare the proportion of APOE ε4 genotype carriers in aphasic vs amnestic variants of Alzheimer disease (AD). Method The proportion of APOE ε4 carriers was compared among the following 3 groups: (1) 42 patients with primary progressive aphasia (PPA) and AD pathology (PPA/AD) enrolled in the Northwestern Alzheimer Disease Center Clinical Core; (2) 1,418 patients with autopsy-confirmed AD and amnestic dementia of the Alzheimer type (DAT/AD); and (3) 2,608 cognitively normal controls (NC). The latter 2 groups were compiled from the National Alzheimer Coordinating Center database. Logistic regression models analyzed the relationship between groups and APOE ε4 carrier status, adjusting for age at onset and sex as needed. Results Using NC as the reference and adjusting for sex and age, the DAT/AD group was 3.97 times more likely to be APOE ε4 carriers. Adjusting for sex and age at symptom onset, the DAT/AD group was 2.46 times as likely to be carriers compared to PPA/AD. There was no significant difference in the proportion of APOE ε4 carriers for PPA/AD compared to NC. PPA subtypes included 24 logopenic, 10 agrammatic nonfluent, and 8 either mixed (n = 5) or too severe (n = 3) to subtype. The proportion of carriers and noncarriers was similar for logopenic and agrammatic subtypes, both having fewer carriers. Conclusion The proportion of APOE ε4 carriers was elevated in amnestic but not aphasic manifestations of AD. These results suggest that APOE ε4 is an anatomically selective risk factor that preferentially increases the vulnerability to AD pathology of memory-related medial temporal areas rather than language-related neocortices.
MiR-652-3p promotes bladder cancer migration and invasion by targeting KCNN3.

OBJECTIVE Increasing evidence indicated that microRNAs (miRNAs) are crucial regulators for cancer development. Bladder cancer (BCa) is a major threat to human health. The aim of this study was to analyze the roles of miR-652-3p in BCa, and to explore the associated mechanisms. MATERIALS AND METHODS MiR-652-3p expression in BCa cell lines was explored using Real Time-quantitative Polymerase Chain Reaction (RT-qPCR) method. MiR-652-3p expression level in BCa tissues was explored at StarBase. Cell Counting Kit-8 (CCK-8) assay, wound-healing assay, and transwell invasion assay were conducted to investigate the biological roles of miR-652-3p. The underlying mechanisms of miR-652-3p in NSCLC were investigated using luciferase activity reporter assay and rescue experiments. RESULTS We showed that miR-652-3p expression level was upregulated in both BCa tissues and cell lines. The knockdown of miR-652-3p significantly inhibited BCa cell proliferation, migration, and invasion in vitro. Moreover, we showed that potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 (KCNN3) was a functional target for miR-652-3p. Besides, the expression of KCNN3 in BCa tissues was negatively correlated with miR-652-3p. CONCLUSIONS Collectively, these results showed that miR-652-3p could promote BCa cell proliferation, migration, and invasion via directly regulating KCNN3, which may provide a novel therapeutic target for BCa treatment.
Effects of inorganic fertilizer on the larval development, adult longevity and insecticide susceptibility in the malaria vector Anopheles arabiensis (Diptera: Culicidae).

BACKGROUND Exposure to inorganic fertilizer is common for the major malaria vector Anopheles arabiensis, which is closely associated with agricultural activities. The aim of this study was to understand if insecticide susceptible and resistant individuals respond to fertilizer exposure in the same manner. Two laboratory strains; SENN, an insecticide susceptible strain and SENN-DDT, an insecticide resistant strain selected strain selected from SENN, were used in this study. Both strains were exposed to one of three concentrations to a combination Nitrogen-Phosphorus-Potassium (NPK) inorganic fertilizer, as well as nitrogenous (Urea), phosphorus (Superphosphate) and kaelic (Potassium chloride-KCl) elemental fertilizer. The time-to-pupation was monitored, adult longevity was assessed and insecticide tolerance of adults was determined. The effect of elemental fertilizers on ovipositioning site choice was also assessed. RESULTS For both strains, urea increased the number of eggs laid, while superphosphate resulted in a significant decrease in egg-laying. Larval NPK exposure decreased time-to-pupation in the SENN strain but not SENN-DDT. Urea exposure increased time-to-pupation in both strains, while KCl decreased time-to-pupation in both strains. Larval NPK exposure only affected adult male longevity at high concentrations. Larval exposure to NPK and KCl resulted in increased insecticide tolerance in both strains, with variable efficacy from strain to strain. CONCLUSION Exposure to inorganic fertilizers has a greater effect on insecticide susceptible An. arabiensis as compared to resistant strains, where the primary advantage is increased insecticide tolerance. These data also demonstrate that larval fertilizer exposure can affect fecundity and fertility, and alter the life histories of adult An. arabiensis. This article is protected by copyright. All rights reserved.
Pazopanib for the treatment of advanced renal cell cancer

Introduction: Understanding of the underlying mechanisms of renal cell carcinoma (RCC) has increased dramatically over the past few years, leading to the development of several targeted biological therapies. Pazopanib is an orally available multi-tyrosine kinase inhibitor that inhibits VEGF receptors 1, 2 and 3, platelet-derived growth factor receptors α and β and the cytokine receptor, KIT. Pazopanib was first approved in the US for the treatment of advanced RCC in 2009. Areas covered: This review discusses the scientific rationale for the use of pazopanib in advanced RCC, summarising pre-clinical and clinical study data, including results from the most recent Phase III clinical studies. The design of future clinical studies for pazopanib is also discussed. Expert opinion: The efficacy and safety of pazopanib have been demonstrated in several clinical trials, as well as non-inferiority to sunitinib for progression-free survival. Pazopanib could become the most commonly used drug for first-line therapy of advanced RCC.
Brazilian norms for the Bank of Standardized Stimuli (BOSS)

Norms for visual stimuli are critical for designing reliable psychological and neuroscientific studies. However, such normative sets of stimuli are scarce for the Brazilian population. Here, we report norms for the Bank of Standardized Stimuli (BOSS) for Brazilian college students. Sixty-five Brazilian university students rated the initial normative set of BOSS images for familiarity and visual complexity, and produced a name for each object. Data analysis focused on comparing the present norms to prior BOSS norms (English-Canadian, French-Canadian, and Thai) across four normative dimensions: familiarity, visual complexity, modal name agreement, and H value, and considered these dimensions according to whether items pertained to living or non-living domains. Correlation analyses revealed that the present norms show strong similarities to prior BOSS norms, although objects were scored as more familiar in the Brazilian relative to all prior norms, especially relative to the Thai norms. In addition, familiarity was greater for living than for non-living items in the English- and French-Canadian norms, but such difference was absent in the Brazilian and Thai norms, suggesting that familiarity is more strongly affected by culture than by semantic domain. In sum, even when cultural differences are considered, the current study reveals that the images of the BOSS data set are in general well known for Brazilians, demonstrating that they can be useful for psychological and neuroscientific research in Brazil.
The genetics of exapted resistance to two exotic pathogens in pedunculate oak.

Exotic pathogens cause severe damage in natural populations in the absence of coevolutionary dynamics with their hosts. However, some resistance to such pathogens may occur in naive populations. The objective of this study was to investigate the genetics of this so-called "exapted" resistance to two pathogens of Asian origin (Erysiphe alphitoides and Phytophthora cinnamomi) in European oak. Host-pathogen compatibility was assessed by recording infection success and pathogen growth in a full-sib family of Quercus robur under controlled and natural conditions. Two high-resolution genetic maps anchored on the reference genome were used to study the genetic architecture of resistance and to identify positional candidate genes. Two genomic regions, each containing six strong and stable QTL accounting for 12-19% of the phenotypic variation, were mainly associated with E. alphitoides infection. Candidate genes, especially genes encoding receptor-like-kinases and galactinol synthases, were identified in these regions. The 3 QTL associated with P. cinnamomi infection did not colocate with QTLs found for E. alphitoides. These findings provide evidence that exapted resistance to E. alphitoides and P. cinnamomi is present in Q. robur and suggest that the underlying molecular mechanisms involve genes encoding proteins with extracellular signaling functions.
A Computational Modeling Reveals That Strength of Inhibitory Input, E/I Balance, and Distance of Excitatory Input Modulate Thalamocortical Bursting Properties

The thalamus is a brain structure known to modulate sensory information before relaying to the cortex. The unique ability of a thalamocortical (TC) neuron to switch between the high frequency burst firing and single spike tonic firing has been implicated to have a key role in sensory modulation including pain. Of the two firing modes, burst firing, especially maintaining certain burst firing properties, was suggested to be critical in controlling nociceptive behaviors. Therefore, understanding the factors that influence burst firing properties would offer important insight into understanding sensory modulation. Using computational modeling, we investigated how the balance of excitatory and inhibitory inputs into a TC neuron influence TC bursting properties. We found that intensity of inhibitory inputs and the timing of excitatory input delivery control the dynamics of bursting properties. Then, to reflect a more realistic model, excitatory inputs delivered at different dendritic locations—proximal, intermediate, or distal—of a TC neuron were also investigated. Interestingly, excitatory input delivered into a distal dendrite, despite the furthest distance, had the strongest influence in shaping burst firing properties, suggesting that not all inputs equally contribute to modulating TC bursting properties. Overall, the results provide computational insights in understanding the detailed mechanism of the factors influencing temporal pattern of thalamic bursts.
Toxoplasmosis: A Silent Opportunistic Diseases in HIV/AIDS Patients

A total of 693 HIV/AIDS patients were recruited in this retrospective and descriptive study during April 2003 to December 2004, Hospital Kuala Lumpur, Malaysia. It was found that both genders were shown to be within the same range of age (M = 18-79 vs F = 18-73), while a median age was slightly higher in male (36 years) than female (31 years). The majority of both genders were significantly shown in the age group of 25 to 34 years, but a higher rate was evident in females (42) (p = 0.001). It was even observed that male patients were mainly Chinese (44.7) and single (57.3) (p = 0.001), while the females were Chinese (40.6) and married (83.3) (p = 0.000). However, the highest numbers of both genders were manifested to be heterosexuals (M = 47.6 vs F = 86.2), followed by intravenous drug users (M = 39.3 vs F = 6.5) (p = 0.000). The range of CD4 cell count was 0 to 1799 with a median of 230 cells/mm3. The level of CD4 cell count of < 200 cells/mm3 was significantly found in males (48.5) and between 200 to 499 and â�¥500 cells/mm3 were 36.2 and 26.8 in females, respectively (p = 0.001). Overall, the Toxoplasma seroprevalence was 43.85 where seropositive of anti-Toxoplasma antibody relatively higher in males (50) than in females (37.7) (p = 0.015). Toxoplasma seropositivity was thoroughly evident among Malays (168; 51.1), Intravenous Drug Users (IDUs) and patients with toxoplasmic encephalitis (TE) (p = 0.001). Furthermore, anti-retroviral therapy including HAART was more significantly found in patients with 9 seropositive Toxoplasma when compared to 2 seronegative and unknown serostatus patients (p = 0.025). Seventeen AIDS-related toxoplasmic encephalitis patients were diagnosed at the time of this study, depicting hemiparesis as the most common neurological manifestation in 11 (64.7) patients, followed by headache and seizure in 6 (35.3) and 3 (17.7) patients, respectively. Interestingly, CT scan finding showed mass like structure with multiple (58.8), ring enhancing lesions (100), in parietal region (58.8) and edema (29.4) in these patients. Overall, the treatment outcome showed that 13 (76.5) patients had completed treatment with maintenance, whereas, 3 (17.6) patients were lost to follow up and 1 (6) patient was transferred to another hospital. No relapse or death case was reported during the time of this study.
Heat Stress-Induced Metabolic Remodeling in Saccharomyces cerevisiae

Yeast cells respond to heat stress by remodeling their gene expression, resulting in the changes of the corresponding proteins and metabolites. Compared to the intensively investigated transcriptome and proteome, the metabolic response to heat stress is not sufficiently characterized. Mitochondria have been recognized to play an essential role in heat stress tolerance. Given the compartmentalization of the cell, it is not clear if the heat stress-induced metabolic response occurs in mitochondria or in the cytosol. Therefore, a compartment-specific metabolite analysis was performed to analyze the heat stress-induced metabolic response in mitochondria and the cytoplasm. In this work, the isolated mitochondria and the cytoplasm of yeast cells grown at permissive temperature and cells adapting to heat stress were subjected to mass spectrometry-based metabolomics. Over a hundred metabolites could be identified, covering amino acid metabolism, energy metabolism, arginine metabolism, purine and pyrimidine metabolism, and others. Highly accumulated citrulline and reduced arginine suggested remodeled arginine metabolism. A stable isotope-labeled experiment was performed to analyze the heat stress-induced metabolic remodeling of the arginine metabolism, identifying activated de novo ornithine biosynthesis to support arginine and spermidine synthesis. The short-term increased spermidine and trehalose suggest their important roles as heat stress markers. These data provide metabolic clues of heat stress-induced metabolic remodeling, which helps in understanding the heat stress response.
Efficacy of home‐based exercise programme on physical function after hip fracture: a systematic review and meta‐analysis of randomised controlled trials

We performed a meta‐analysis to evaluate the effect of home exercise programmes on body function after hip fractures. A computerised literature search was performed for published trials in PubMed, EMBASE, CENTRAL, and Cochrane Database of Systematic Reviews. Randomised trials were selected investigating home‐based exercise programmes vs usual care without home‐based exercise in hip fracture patients. Physical health (measured by Short Form 36), normal gait speed, fast gait speed, balance, instrumental activities of daily living (IADL), activities of daily living (ADL), lower extremity strength, leg strength in fractured leg, leg strength in non‐fractured leg, and Six‐Minute Walk Test (6MWT) per randomised patient were measured as outcomes. Eleven randomised controlled trials of 1068 subjects were included, 533 in the home‐based exercise group and 535 in the control group. The results of this meta‐analysis showed that the home‐based exercise programmes were not significantly associated with physical health, normal gait speed, fast gait speed, balance, IADL, ADL, and lower extremity strength but were significantly associated with leg strength in the fractured leg, leg strength in the non‐fractured leg, and 6MWT. The home‐based exercise programme had a positive, although not significant, effect on physical function after hip fracture. Low‐intensity training and poor patient compliance are unavoidable problems in home‐based exercise rehabilitation. A more task‐oriented rehabilitation programme might possibly yield more benefits for disability outcomes.
Phosphodiesterase 4D (PDE4D) Gene Variants and Risk of Ischemic Stroke in the Taiwanese Population

Objectives: It has been suggested that genetic variants in the phosphodiesterase 4D (PDE4D) gene confer risk of ischemic stroke. However, the cerebral infarction/cerebral hemorrhage ratio is lower in Asian populations compared with those in Caucasian and black populations. Thus, the association between variations in the PDE4D gene and ischemic stroke in Taiwan needs to be replicated. In the present study, we evaluated whether the PDE4D gene polymorphism confers a risk of ischemic stoke in Taiwanese patients. Methods: Two single-nucleotide polymorphisms (SNPs) covering the PDE4D gene were genotyped using genomic DNA sequencing and a high-throughput TaqMan PCR assay in 100 patients who had suffered an ischemic stroke and 270 healthy individuals. Results: No significant associations with ischemic stroke were observed with the SNP87 (rs2910829) or SNP41 (rs152312) SNPs from PDE4D, which were a part of the Icelandic at-risk haplotypes. Conclusions: The present data does not support a significant role for PDE4D polymorphisms in genetic susceptibility to ischemic stroke in the Taiwanese population.