Miracle-dz/UniFAR-FTUs huggingface dataset:
Pengaruh Penatausahaan dan Penerapan Sistem Informasi Manajemen Akuntansi Barang Milik Negara (SIMAK BMN) terhadap Kualitas Laporan Keuangan (Studi pada Kantor Pusat dan Kantor Wilayah Direktorat Jenderal Kekayaan Negara DKI Jakarta)

Penelitian ini dilakukan untuk mengetahui pengaruh penatausahaan, dan penerapan Sistem Informasi Manajemen Akuntansi Barang Milik Negara (SIMAK BMN) terhadap kualitas laporan keuangan pada Kantor Pusat dan Kantor Wilayah Direktorat Jenderal Kekayaan Negara DKI Jakarta baik secara simultan maupun secara parsial. Penelitian ini dilakukan dengan menyebarkan kuesioner. Populasi dalam penelitian ini adalah karyawan yang ditunjuk sebagai petugas akuntansi BMN pada Kantor Pusat dan Kantor Wilayah DKI Jakarta, seluruh populasi dalam penelitian ini dijadikan sampel. Analisis data menggunakan SPSS versi 23 dengan variabel bebas adalah pembukuan, inventarisasi dan pelaporan BMN, variabel terikatnya adalah kualitas laporan keuangan. Teknik analisis data yang digunakan adalah regresi linear berganda, dan ditemukan hasil bahwa pembukuan, inventarisasi, pelaporan, dan penerapan SIMAK BMN secara simultan berpengaruh terhadap kualitas laporan keuangan. Secara parsial ditemukan bahwa pembukuan berpengaruh positif signifikan terhadap kualitas laporan keuangan, inventarisasi tidak berpengaruh terhadap kualitas laporan keuangan, pelaporan tidak berpengaruh signifikan tetapi berpengaruh secara positif terhadap kualitas laporan keuangan, dan SIMAK BMN tidak berpengaruh terhadap kualitas laporan keuangan. Kata Kunci : Pembukuan, Inventarisasi, Pelaporan, SIMAK BMN dan kualitas laporan keuangan.
Hierarchical and Interpretable Skill Acquisition in Multi-task Reinforcement Learning

Learning policies for complex tasks that require multiple different skills is a major challenge in reinforcement learning (RL). It is also a requirement for its deployment in real-world scenarios. This paper proposes a novel framework for efficient multi-task reinforcement learning. Our framework trains agents to employ hierarchical policies that decide when to use a previously learned policy and when to learn a new skill. This enables agents to continually acquire new skills during different stages of training. Each learned task corresponds to a human language description. Because agents can only access previously learned skills through these descriptions, the agent can always provide a human-interpretable description of its choices. In order to help the agent learn the complex temporal dependencies necessary for the hierarchical policy, we provide it with a stochastic temporal grammar that modulates when to rely on previously learned skills and when to execute new skills. We validate our approach on Minecraft games designed to explicitly test the ability to reuse previously learned skills while simultaneously learning new skills.
Transforming Growth Factor -activated Kinase 1 (TAK1) Kinase Adaptor, TAK1-binding Protein 2, Plays Dual Roles in TAK1 Signaling by Recruiting Both an Activator and an Inhibitor of TAK1 Kinase in Tumor Necrosis Factor Signaling Pathway*

Peter Broglie, Kunihiro Matsumoto, Shizuo Akira, David L. Brautigan , and Jun Ninomiya-Tsuji From the Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, North Carolina 27695, the Department of Molecular Biology, Graduate School of Science, Nagoya University, Nagoya 464-8602 Japan, the Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan, and the Center for Cell Signaling, University of Virginia School of Medicine, Charlottesville, Virginia 22908
Chemokine Profile of Herniated Intervertebral Discs Infiltrated With Monocytes and Macrophages

Study Design. Herniated lumbar disc specimens were analyzed using reverse transcriptase–polymerase chain reaction to determine the profile of chemokine expression. Objective. To investigate the mechanism underlying the recruitment of inflammatory cells into herniated discs during the process of spontaneous regression. Summary of Background Data. Spontaneous regression of herniated intervertebral discs has been increasingly reported. Although macrophages are suggested to play a central role in this process, it remains unclear how these macrophages accumulate in the herniated discs. Methods. RNA was extracted from 36 surgical specimens of the herniated lumbar disc, a disc specimen of idiopathic scoliosis and pyogenic spondylitis, and activated peripheral blood mononuclear cells of a normal donor. The RNA was reverse transcribed, and the resultant cDNA was amplified by PCR using primer pairs specific to the CXC chemokines (IL-8, MGSA-&agr;, IP-10, MIG), the CC chemokines (MCP-1, MCP-2, MCP-3, MCP-4, MIP-1&agr;, MIP-3&agr;, RANTES, STCP-1), the C chemokine (lymphotactin), and the glyceraldehyde phosphate housekeeping gene. Thin cryostat sections also were made from the disc specimens and stained with hematoxylin and eosin. Results. All the chemokines examined except MCP-4 were expressed by activated peripheral blood mononuclear cells. Glyceraldehyde phosphate was detected in 8 of 36 herniated discs and in 1 disc specimen each of idiopathic scoliosis and pyogenic spondylitis. Chemokine expression was examined for these 10 disc specimens. From among the 13 chemokines examined, MCP-3, MCP-4, RANTES, and IP-10 were detected in the disc from the idiopathic scoliosis, and MCP-3, MCP-4, RANTES, IP-10, MIG, and MGSA-&agr; were detected in the infected or herniated discs. Histologic analysis showed infiltration of inflammatory cells in the infected disc and all 8 herniated discs. Conclusions. The findings suggest that chemoattractive properties exist in a selected population of human intervertebral discs, and that unique sets of chemokinesplay a role in spontaneous regression of these herniated disc tissues.
CERAD test performances in amnestic mild cognitive impairment and Alzheimer's disease

Objectives – The aim of the study was to examine the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) test performances cross‐sectionally in patients suffering from amnestic mild cognitive impairment (MCI) and mild Alzheimer's disease (AD). Moreover, we wanted to determine the sensitivity to amnestic MCI and mild AD, as well as the specificity of different CERAD subtests in our study groups.
Effect of acupuncture on cardiopulmonary function.

OBJECTIVE To evaluate the relationship between acupuncture and cardiopulmonary function in healthy people. SUBJECTS AND METHODS Healthy male volunteers were divided into 3 groups, 16 of persons each Group 1 was treated with acupuncture at points Neiguan (PC6) and Zusanli (ST36): Group 2 was treated with acupuncture at non-acupoints, and Group 3 was taken as control. The effects of resting cardiopulmonary functions were measured with gas analysis system. The resting heart rate (HR), oxygen consumption (VO2), and carbon dioxide production (VCO2) were recorded over a thirty-minute period at intervals of five minutes, 15 minutes, and 25 minutes. Electroacupuncture was given to Groups 1 and 2. The analysis of variance and t test were used in data analysis. RESULTS In the acupuncture groups, resting heart rate and carbon dioxide production decreased (P < 0.05) and oxygen consumption also decreased slightly, although it was statistically insignificant (P > 0.05). CONCLUSION Our results indicate that acupuncture can decrease the resting heart rate and carbon dioxide production, thus lowering the metabolic rate.
Antidiabetic and Antihyperlipidemic Effects of Ethanol Extract of Rosa canina L. fruit on Diabetic Rats

Rosa canina L. (Rosaceae) has been traditionally used as a medicinal plant. This study was undertaken to evaluate the antidiabetic and antihyperlipidemic effects of Rosa canina fruit extract in streptozotocin induced diabetic rats. The results showed oral administration of Rosa canina fruit extract significantly ameliorated the high levels of blood glucose compared with the control group. Serum triglyceride levels significantly decreased by the administration of Rosa canina extract compared with control. Histopathological examinations showed that the Rosa canina extract improved islets necrotic and regenerated pancreatic islet cells. Rosa canina extract has the antihyperglycemic and antihyperlipidemic effects in streptozotocin-induced diabetic rats.
bovine colostrum – the promising nutraceutical

A������� B. , M������ T�. , N������� E. (2004): Bovine colostrum – the promising nutraceutical. Czech J. Food Sci., 22: 73–79. Colostrum is the first milk produced after birth and is particularly rich in immunoglobulins, antimicrobial peptides, and growth factors. It is important for the nutrition, growth, and development of newborn infants and contributes to the immunologic defence of neonates. Recent studies suggest that bovine colostrum or some of its constituents may be useful for the prevention and, to some extent, for the treatment of various infectious diseases. A variety of colostral based preparations have been used as feed supplements or colostrum substitutes for neonate calves and pigs. Numerous recent studies suggest that oral administration of bovine colostrum preparations may contribute to human health care both as part of health promoting diet and as an alternative or a supplement to the medical treatment of specified human diseases.
Evaluation of two commercially prepared biphasic media for recovery of fungi from blood

Recovery of six yeast species from blood was comparable in commercially prepared brain heart infusion biphasic and Trypticase soy biphasic media. An increased recovery of 13% was noted when two bottles, each containing 5 ml of blood, were cultured, as compared to a 5-ml portion in a single culture bottle.
Subcortical Aphasia(s): A Controversial and Promising Topic

Many aspects of subcortical aphasias are not accounted for by a unique pathophysiological mechanism; rather the diversity of the observed symptoms suggests that many functional ensembles, more or less related, to language functions may be disturbed by subcortical lesions. However, such disorders are only moderate in intensity and subcortical aphasias certainly constitute an interesting model for studying the dynamics of recovery of language functions and related neural systems, combining neurolinguistic concepts with advanced functional imaging techniques.
Development of 21 new microsatellite markers in Labeo rohita (rohu).

References 1 Hood J. C. (1999) Bull Terrier hereditary nephritis: an animal model for autosomal dominant Alport Syndrome. PhD thesis, Murdoch University, Perth. 2 Pescucci C. et al. (2004) Kidney Int 65, 1598–603. 3 Arrondel C. et al. (2002) J Am Soc Nephrol 13, 65–74. 4 Wiersma A. C. et al. (2005) J Hered 96, 739–44. 5 Oetting W. S. et al. (1995) Genomics 30, 450–8. 6 Sobel E. et al. (1996) Am J Hum Genet 58, 1323–37. 7 Sobel E. et al. (2001) Hum Hered 52, 121–31. 8 Magnuson V. L. et al. (1996) Biotechniques 21, 700–9.
Prospective, longitudinal study of tic, obsessive-compulsive, and attention-deficit/hyperactivity disorders in an epidemiological sample.

OBJECTIVE Understanding the interrelatedness of tics, obsessive-compulsive disorder (OCD), and attention-deficit/hyperactivity disorder (ADHD) has been complicated by studying only cross-sectional samples of clinically referred subjects. The authors report the cross-sectional and longitudinal associations of these disorders in an epidemiological sample of children followed prospectively into early adulthood. METHOD Structured diagnostic interview information was acquired on 976 children, aged 1 to 10 years, who were randomly selected from families living in upstate New York in 1975. Reassessments were acquired in 776 of these subjects 8, 10, and 15 years later. Diagnostic prevalences were estimated at each time point. The associations among tics, OCD, and ADHD were assessed within and across time points, as were their associations with comorbid illnesses and demographic risk factors. RESULTS In temporal cross-section, tics and ADHD symptoms were associated with OCD symptoms in late adolescence and early adulthood after demographic features and comorbid psychiatric symptoms were controlled. In prospective analyses, tics in childhood and early adolescence predicted an increase in OCD symptoms in late adolescence and early adulthood. ADHD symptoms in adolescence predicted more OCD symptoms in early adulthood, and OCD in adolescence predicted more ADHD symptoms in adulthood. The associations of tics with ADHD were unimpressive in temporal cross-section and were not significant in prospective analyses. Tics, OCD, and ADHD shared numerous complex associations with demographic and psychopathological risk factors. ADHD was associated with lower IQ and lower social status, whereas OCD was associated with higher IQ. CONCLUSIONS Tics and OCD were significantly associated in this sample, as were OCD and ADHD. These findings are in general consistent with those from family studies, and they help to define the natural history, comorbid illnesses, and interrelatedness of these conditions.
Abl Interactor 1 (Abi-1) Wave-Binding and SNARE Domains Regulate Its Nucleocytoplasmic Shuttling, Lamellipodium Localization, and Wave-1 Levels

ABSTRACT The Abl interactor 1 (Abi-1) protein has been implicated in the regulation of actin dynamics and localizes to the tips of lamellipodia and filopodia. Here, we show that Abi-1 binds the actin nucleator protein Wave-1 through an amino-terminal Wave-binding (WAB) domain and that disruption of the Abi-1-Wave-1 interaction prevents Abi-1 from reaching the tip of the lamellipodium. Abi-1 binds to the Wave homology domain of Wave-1, a region that is required for translocation of Wave-1 to the lamellipodium. Mouse embryo fibroblasts that lack one allele of Abi-1 and are homozygous null for the related Abi-2 protein exhibit decreased Wave-1 protein levels. This phenotype is rescued by Abi-1 proteins that retain Wave-1 binding but not by Abi-1 mutants that cannot bind to Wave-1. Moreover, we uncovered an overlapping SNARE domain in the amino terminus of Abi-1 that interacts with Syntaxin-1, a SNARE family member. Further, we demonstrated that Abi-1 shuttles in and out of the nucleus in a leptomycin B (LMB)-dependent manner and that complete nuclear translocation of Abi-1 in the absence of LMB requires the combined inactivation of the SNARE, WAB, and SH3 domains of Abi-1. Thus, Abi-1 undergoes nucleocytoplasmic shuttling and functions at the leading edge to regulate Wave-1 localization and protein levels.
Aryl hydrocarbon receptor‐mediated impairment of chondrogenesis and fracture healing by cigarette smoke and benzo(α)pyrene

The clinical literature strongly suggests that bone healing in cigarette smokers is impaired. Since cigarette smoke (CS) contains numerous polycyclic aromatic hydrocarbons (PAHs), and since dioxins impair bone formation in vivo via the Aryl Hydrocarbon Receptor (AHR), we investigated the impact of PAH/AHR signaling on chondrogenesis and on healing in a mouse tibial fracture model. We established that CS activates AHR signaling in fractures by up‐regulating the AHR target gene cytochrome p4501A1 (Cyp1A1). For in vitro studies, we employed the mouse limb bud micromass chondrogenesis model. After confirming that chondrocytes express AHR during differentiation, we treated cells with a prototypical PAH found in CS, benzo(α)pyrene (BaP), or cigarette smoke extract (CSE). Both BaP and CSE strongly inhibited chondrogenesis in mesenchymal cells generated from E11 limb buds, with BaP also accelerating chondrocyte hypertrophy in cultures generated from E12 limb buds. Detection of DNA adducts in the BaP‐treated cultures suggests that the distinct phenotypic effects of BaP may be due to the formation of reactive metabolites. Blockade of AHR signaling with the AHR antagonist MNF reverses the effects of BaP, but not CSE, suggesting that CSE inhibition of chondrogenesis is AHR‐independent. Correlating with these results, tibial fracture calluses from BaP‐treated mice were smaller and contained less mineralized tissue than vehicle controls. Overall, BaP is identified as a potent inhibitor of chondrogenesis in vitro with correlated effects on fracture healing similar to those of CS itself, suggesting a basis for PAHs as key compounds in the influence of CS on fracture repair. J. Cell. Physiol. 227: 1062–1070, 2012. © 2011 Wiley Periodicals, Inc.
The hygiene hypothesis revisited: does exposure to infectious agents protect us from allergy?

Purpose of review The increase in incidence and prevalence of allergic disease remains a mystery and cannot be explained solely by genetic factors. The hygiene hypothesis provides the strongest epidemiological explanation for the rise in allergic disease. This review evaluates the recent epidemiological and mechanistic research in the role of infectious agents in the pathogenesis of or protection from allergic disease. Recent findings Recent literature has extended the epidemiological findings of the protective effect of being born and reared in a farm environment and associates an increased diversity of organisms in house-dust samples with protection from allergic disease. Furthermore, human and animal studies provide increasing evidence for the role of both the innate and adaptive immune systems, including regulatory cells, as mediators of this protective effect. Summary There is evidence that exposure to some infectious organisms can protect from atopy, whereas other infections appear to promote allergic diseases. The timing of exposure to infection and the properties of the infectious agent, in addition to the genetic susceptibility of the host, play an important role in the future development of allergic disease.
Hydrodynamic description of protein folding: the decrease of the probability fluxes as an indicator of transition states in two-state folders

Abstract Using hydrodynamic description of protein folding, the process of the first-passage folding of ubiquitin has been studied. Since a large number of folding trajectories were required to obtain converged folding flows, a coarse-grained representation of the protein in the form of a C-bead Gō-model was employed, and discrete molecular dynamics was used to perform simulations. It has been found that the free energy surface has a maximum width in the transition state region, so that the densities of folding flows (probability fluxes) decrease to minimum when the system passes through the transition state. There are indications that the increasing number of different protein conformations in the transition state region compared with those in the neighboring regions of semi-compact and native-like states is responsible for the present phenomena. It has also been shown that if the free energy is projected onto a single reaction coordinate, the low populations of the transition states can be compensated by the increasing number of states, which can lead to a considerable decrease or even disappearance of the free energy barrier in the transition state.
Efficacy, tolerance, and pharmacokinetics of once daily tobramycin for pseudomonas exacerbations in cystic fibrosis

OBJECTIVE To compare once daily with thrice daily tobramycin for treatment of Pseudomonas aeruginosainfection in patients with cystic fibrosis. DESIGN 22 patients with cystic fibrosis, mean (SD) age 11 (3.4) years (range 5.6–19.3), with pulmonary pseudomonas exacerbations were randomly assigned to receive a 14 day course of tobramycin (15 mg/kg/day) either in three infusions (group A) (n = 10) or a single daily infusion (group B) (n = 12), combined with ceftazidime (200 mg/kg/day as three intravenous injections). Efficacy was assessed by comparison of pulmonary, nutritional, and inflammatory indices on days 1 and 14. Cochlear and renal tolerance were assessed on days 1 and 14. Tobramycin concentration was measured in serum and sputum 1, 2, 3, 4, 8, and 24 hours after the start of the infusion. Analysis was by non-parametric Wilcoxon test. RESULTS Variables improving (p < 0.05) in both groups A and B were, respectively: weight/height (+4% and +3.1%), plasma prealbumin (+66 and +63 mg/l), forced vital capacity (FVC) (+14% and +11%), forced expiratory volume in one second (+15% and +14%), and forced expiratory flow between 25% and 75% of FVC (+13% and +21%). Improvement was not significantly different between groups. Renal and cochlear indices remained within the normal range. Serum peak concentration of tobramycin on day 1 was 13.2 (7.1) mg/l in group A and 42.5 (11.2) mg/l in group B (p < 0.001); serum trough was 1.1 (0.8) mg/l in group A and 0.3 (0.2) mg/l in group B (p < 0.01). Tobramycin concentrations in sputum were two to three times higher in group B than group A. CONCLUSIONS Once daily tobramycin combined with three injections of ceftazidime is safe and effective for the treatment of pseudomonas exacerbations in cystic fibrosis patients.
A path analysis of intention to redonate among experienced blood donors: an extension of the theory of planned behavior

BACKGROUND: The need for blood products is constant and unremitting, yet only a small percentage of eligible individuals answer the appeal to donate. Further, most new donors never return to provide a repeat donation. The ongoing need to attract and retain new donors has led to the examination of psychosocial factors that may predict the likelihood of blood donation behavior. By use of regression techniques, prior studies have established that elements of the Theory of Planned Behavior (e.g., attitude, subjective norm, personal moral norm, and perceived control or self‐efficacy) can predict intention to donate among nondonors.
Performance of a new gadolinium‐based intravascular contrast agent in free‐breathing inversion‐recovery 3D coronary MRA

In three‐dimensional (3D) coronary magnetic resonance angiography (MRA), the in‐flow contrast between the coronary blood and the surrounding myocardium is attenuated as compared to thin‐slab two‐dimensional (2D) techniques. The application of a gadolinium (Gd)‐based intravascular contrast agent may provide an additional source of signal and contrast by reducing T1blood and supporting the visualization of more distal or branching segments of the coronary arterial tree. In six healthy adults, the left coronary artery (LCA) system was imaged pre‐ and postcontrast with a 0.075‐mmol/kg bodyweight dose of the intravascular contrast agent B‐22956. For imaging, an optimized free‐breathing, navigator‐gated and ‐corrected 3D inversion recovery (IR) sequence was used. For comparison, state‐of‐the‐art baseline 3D coronary MRA with T2 preparation for non‐exogenous contrast enhancement was acquired. The combination of IR 3D coronary MRA, sophisticated navigator technology, and B‐22956 allowed for an extensive visualization of the LCA system. Postcontrast, a significant increase in both the signal‐to‐noise ratio (SNR; 46%, P < 0.05) and contrast‐to‐noise ratio (CNR; 160%, P < 0.01) was observed, while vessel sharpness of the left anterior descending (LAD) artery and the left coronary circumflex (LCX) were improved by 20% (P < 0.05) and 18% (P < 0.05), respectively. Magn Reson Med 49:115–121, 2003. © 2003 Wiley‐Liss, Inc.
The earliest Bronze Age culture of the south-eastern Gobi Desert, Mongolia

Abstract Studies of the Eurasian Bronze Age have tended to emphasise the homogeneity of social and political processes across the Steppe, evidenced by a common ‘package’ of practices and material culture. The Dornod Mongol Survey examines the major stone monumental forms and associated features of the Ulaanzuukh mortuary tradition of the Gobi region of Mongolia. Combining evidence for mortuary and ritual practices, ceramic traditions and new radiocarbon dates, the authors argue that the appearance of the earliest Bronze Age cultures in this region represents a disparate collection of local, regional and inter-regional expressions that challenge the established narrative of a ‘standard’ Eurasian Bronze Age.