Miracle-dz/UniFAR-FTUs huggingface dataset:
Prediction of medial and lateral contact force of the knee joint during normal and turning gait after total knee replacement

The computational modeling approach has commonly been used to predict knee joint contact forces, muscle forces, and ligament loads during activities of daily living. Knowledge of these forces has several potential applications, for example, within design of equipment to protect the knee joint from injury and to plan adequate rehabilitation protocols, although clinical applications of computational models are still evolving and one of the limiting factors is model validation. The objective of this study was to extend previous modeling technique and to improve the validity of the model prediction using publicly available data set of the fifth “Grand Challenge Competition to Predict In Vivo Knee Loads. ” A two-stage modeling approach, which combines conventional inverse dynamic analysis (the first stage) with a multi-body subject-specific lower limb model (the second stage), was used to calculate medial and lateral compartment contact forces. The validation was performed by direct comparison of model predictions and experimental measurement of medial and lateral compartment contact forces during normal and turning gait. The model predictions of both medial and lateral contact forces showed strong correlations with experimental measurements in normal gait (r = 0.75 and 0.71) and in turning gait trials (r = 0.86 and 0.72), even though the current technique over-estimated medial compartment contact forces in swing phase. The correlation coefficient, Sprague and Geers metrics, and root mean squared error indicated that the lateral contact forces were predicted better than medial contact forces in comparison with the experimental measurements during both normal and turning gait trials.
Plasma Fatty Acid Composition in Patients with Pancreatic Cancer: Correlations to Clinical Parameters

Pancreatic cancer (PC) ranks as the fourth cause of cancer-related deaths in the Czech Republic. Evidence exists that deregulation of fatty acid (FA) metabolism is connected with some malignancies; therefore, we decided to analyze FA profile in plasma lipid classes in patients with PC with relation to tumor staging, nutritional status, and survival. The study included 84 patients (47 males, 37 females) with PC and 68 controls (36 males, 32 females). FA patterns were analyzed in plasma lipid classes by gas-chromatography. We observed increased proportion of total monounsaturated FA (MUFA) in PC group in all plasma lipid classes. These changes were connected with increased Δ9-desaturase (SCD1) and Δ5-desaturase indices. Correlations of dihomo-γ-linolenic acid (DHGLA) with these variables were opposite. Longer survival of patients was connected with higher content of EPA, DHA, and with lower SCD1 index, respectively. Plasma phospholipid proportions of α-linolenic acid, DHGLA, EPA, and n-3 polyunsaturated fatty acids displayed negative trend with tumor staging. Plasma lipid FA pattern in PC patients resulted from decreased dietary fat intake and increased de novo synthesis of FA with transformation into MUFA. Changes in FA profile implicated some pathophysiological mechanisms responsible for disturbed FA metabolism in PC and importance of appropriate nutritional support.
Fine Particulate Air Pollution and Total Mortality Among Elderly Californians, 1973–2002

Fine particulate air pollution has been associated with increases in long-term mortality in selected cohort studies, and this association has been influential in the establishment of air quality regulations for fine particles (PM2.5). However, this epidemiologic evidence has been questioned because of methodological issues, conflicting findings, and lack of an accepted causal mechanism. To further evaluate this association, the long-term relation between fine particulate air pollution and total mortality was examined in a cohort of 49, 975 elderly Californians, with a mean age of 65 yr as of 1973. These subjects, who resided in 25 California counties, were enrolled in 1959, recontacted in 1972, and followed from 1973 through 2002; 39, 846 deaths were identified. Proportional hazards regression models were used to determine their relative risk of death (RR) and 95% confidence interval (CI) during 1973–2002 by county of residence. The models adjusted for age, sex, cigarette smoking, race, education, marital status, body mass index, occupational exposure, exercise, and a dietary factor. For the 35, 789 subjects residing in 11 of these counties, county-wide exposure to fine particles was estimated from outdoor ambient concentrations measured during 1979–1983 and RRs were calculated as a function of these PM2.5 levels (mean of 23.4 μg/m3). For the initial period, 1973–1982, a small positive risk was found: RR was 1.04 (1.01–1.07) for a 10-μ g/m3 increase in PM2.5. For the subsequent period, 1983–2002, this risk was no longer present: RR was 1.00 (0.98–1.02). For the entire follow-up period, RR was 1.01 (0.99–1.03). The RRs varied somewhat among major subgroups defined by sex, age, education level, smoking status, and health status. None of the subgroups that had significantly elevated RRs during 1973–1982 had significantly elevated RRs during 1983–2002. The RRs showed no substantial variation by county of residence during any of the three follow-up periods. Subjects in the two counties with the highest PM2.5 levels (mean of 36.1 μg/m3) had no greater risk of death than those in the two counties with the lowest PM2.5 levels (mean of 13.1 μg/m3). These epidemiologic results do not support a current relationship between fine particulate pollution and total mortality in elderly Californians, but they do not rule out a small effect, particularly before 1983.
Adverse Effects of Low Level Heavy Metal Exposure on Male Reproductive Function

Lead, cadmium, mercury, and arsenic, often referred to as “heavy metals”, are toxic for wildlife, experimental animals, and humans. While experimental animal and human occupational studies with high exposure levels generally support an adverse role for these metals in human reproductive outcomes, information on the effects of low, environmentally-realistic exposure levels of these metals on male reproductive outcomes is limited. We review the literature on effects of exposure to low levels of these metals on measures of male fertility (semen quality and reproductive hormone levels) and provide supporting evidence from experimental and occupational studies. Potentially modifying effects of genetic polymorphisms on these associations are discussed. A brief review of the literature on the effects of three trace metals, copper, manganese, and molybdenum, that are required for human health, yet may also cause adverse reproductive effects, follows. Overall, there were few studies examining the effects of exposure to low levels of these metals on male reproductive health. For all metals, there were several well-designed studies with sufficient populations appropriately adjusted for potential confounders and many of these reported harmful effects. However, many studies lacked sufficient numbers of participants to be able to detect differences in outcomes between exposed and non-exposed individuals, did not clearly identify the source and characteristics of the participants, and did not control for other exposures that could alter or contribute to the outcomes. The evidence for the effects of low exposure was strongest for cadmium, lead, and mercury and less certain for arsenic. The potential modifying effects of genetic polymorphisms has not been fully explored. Additional studies on the reproductive effects of these toxic ubiquitous metals on male reproduction are required to expand the knowledge base and to resolve inconsistencies.
Cost-effectiveness of a new interferon-based blood assay, QuantiFERON-TB Gold, in screening tuberculosis contacts.

BACKGROUND Recent approval of interferon-gamma release assays that are more specific for Mycobacterium tuberculosis has given new options for the diagnosis of latent tuberculosis infection (LTBI). OBJECTIVE To assess the cost-effectiveness of Quanti-FERON-TB Gold (QFT-G) vs. the tuberculin skin test (TST) in diagnosing LTBI in contacts of active TB cases using a decision analytic Markov model. METHODS Three screening strategies--TST alone, QFT-G alone and sequential screening of TST then QFT-G--were evaluated. The model was further stratified according to ethnicity and bacille Calmette-Guérin (BCG) vaccination status. Data sources included published studies and empirical data. Results were reported in terms of the incremental net monetary benefit (INMB) of each strategy compared with the baseline strategy of TST-based screening in all contacts. RESULTS The most economically attractive strategy was to administer QFT-G in BCG-vaccinated contacts, and to reserve TST for all others (INMB CA$3.70/contact). The least cost-effective strategy was QFT-G for all contacts, which resulted in an INMB of CA$-11.50 per contact. Assuming a higher prevalence of recent infection, faster conversion of QFT-G, a higher rate of TB reactivation, reduction in utility or greater adherence to preventive treatment resulted in QFT-G becoming cost-effective in more subgroups. CONCLUSIONS Selected use of QFT-G appears to be cost-effective if used in a targeted fashion.
The Internet as a Communication Tool for Academic Orthopaedic Surgery Departments in the United States

Background: The Internet’s appeal as an affordable, accessible medium for information transfer makes it a potentially useful tool for practicing physicians. In the past several years, Internet-based health-care companies have proliferated, and many medical centers have established individual web sites. The purpose of the present study was to evaluate academic orthopaedic surgery departments in the United States with respect to Internet visibility and content. Methods: We reviewed existing web sites for the 154 departments or divisions of orthopaedic surgery currently accredited for resident education by the Accreditation Council for Graduate Medical Education. The study sample consisted of the 113 departments that had a web page listed in the FREIDA (Fellowship and Residency Electronic Interactive Database) database. Each web site was assessed with regard to its informational value in the categories of clinical services, resident education, and physician recruitment. In addition, three commonly employed browsing engines were used to search for individual web sites and to determine their ease of accessibility. Results: In the category of clinical services, sixty-five (57.5%) of the 113 sites provided faculty listings and forty-nine (43.4%) provided office telephone numbers and locations. Only thirteen sites provided information on common orthopaedic conditions, and five had links to other patient-education sites. In the category of resident education, twenty-four sites (21.2%) had online academic schedules, but only two provided access to complete conferences or teaching files. In the category of physician recruitment, ninety-one provided a description of their residency program and fifty-four had information on the application process, but only twenty-six web pages offered detailed departmental statistics. In terms of accessibility, fifty-three programs (46.9%) were identified by one of three popular search engines, seventeen (15%) were identified by more than one search engine, and two (1.8%) were identified by all three. Conclusions: Academic orthopaedic surgery departments in the United States underutilize the Internet as a source of clinical and educational services. In addition, existing orthopaedic web sites are difficult to access with use of popular search engines. Thus, academic orthopaedic surgery departments in the United States are missing a valuable opportunity to promote awareness of their institutions and to become educational resources for the community.
Long-Term Impact of Vietnam War Service on Family Environment and Satisfaction

The authors surveyed 47 midwestern Vietnam war veterans about their war experiences, current lives, and perspectives of their families at this time. Results indicated significant associations between combat exposure and the development of psychological impairment as well as associations between psychological impairment and family environment and satisfaction. No significant associations were found between combat exposure and family environment or satisfaction. Results suggest the need for increased interventions at a family level for survivors of war trauma. Implications for counselors are discussed.
Growth of Laparoscopic Colectomy in the United States: Analysis of Regional and Socioeconomic Factors Over Time

Objective: The study was designed to determine the growth pattern and current rate of laparoscopic partial colectomy in the United States and analyze various factors that influence the adaptation rate over time. Background: Laparoscopic colectomy has been shown to have significant short- and long-term benefits compared with the open approach. Despite the evidence from multiple, prospective, randomized trials, the adoption rate in the Unites States is reported to be low. Methods: The Nationwide Inpatient Database was used to estimate the rate of laparoscopic partial colectomy in the United States for the years 1996, 2000, 2004, 2008, and 2009 and examine the growth pattern. Multivariate logistic regression analysis was used to determine the impact of the following patient and hospital variables: age, sex, race, payer status, hospital region, and hospital location and teaching status. Significant factors were analyzed for changes over time. Results: Overall, 226,585 partial colectomies were identified. The rate of laparoscopic colectomy was 2.2% (878/38,264) for 1996, 2.7% (1175/42,166) for 2000, 5% (2336/44,817) for 2004, 15% (7548/42,903) for 2008, and 31.4% (14,610/31,888) for 2009. A noticeable change of the growth rate of laparoscopic partial colectomies was noted after 2004, with a significant increase and a possible tipping point after 2008. Urban hospital location [odds ratio (OR = 1.71)], teaching hospital status (OR = 1.21), and private insurance status (OR = 1.46) are significant hospital characteristics predicting the use of laparoscopy overall, but teaching hospital status is not significant after 2008 (OR = 1.51 in 1996 to OR = 1.09 in 2008). Age above 80 years significantly decreases the utilization of laparoscopy (OR = 0.78 for age 80–89 years and 0.69 for >90 years). African American race (OR = 0.84), Medicaid insurance status (OR = 0.52), and self-pay (0.6) are significant socioeconomic characteristics negatively influencing the use of the minimal invasive technique. Conclusions: A marked increase in the rate of laparoscopic colectomy is seen in recent years. The minimal invasive technique seems to be increasingly used in nonteaching hospitals. Significant socioeconomic differences in access to minimal invasive techniques persist.
Volume specific response criteria for brain metastases following salvage stereotactic radiosurgery and associated predictors of response

Abstract Background. We aimed to derive three-dimensional volume-based (V3D) response criteria that approximate those based on Response Evaluation Criteria in Solid Tumours (RECIST) in patients with brain metastases (BM) treated with salvage stereotactic radiosurgery (SRS). Material and methods. Seventy patients with 178 BM were treated with SRS. Each BM was characterised at baseline and at each follow-up MRI according to its widest diameter and V3D using ITK-SNAP image segmentation software. Results. The median tumour diameter was 1.2 cm (range, 0.2–4.5 cm) and V3D was 0.73 cm3 (range, 0.01–22.7 cm3). The V3D percent changes that best matched RECIST response criteria were: an increase of ≥71.5% for progressive disease, a ≥58.5% decrease for partial response and a <58.5% decrease or increase of <71.5% for stable disease (k =0.85). A baseline diameter >3.0 cm (p =0.006) and a V3D >6.0 cm3 (p =0.043) predicted for local failure, and a baseline cumulative V3D of >3.0 cm3 (p =0.02) was adversely prognostic for survival. Conclusions. We define 3D volume specific criteria to base response upon for brain metastases treated with salvage SRS. Tumours with a V3D of greater than 6 cm3 are at a higher risk of local failure.
Impact of Channel Estimation Errors on Various Spatial-Temporal Transmission Schemes

Herein, we investigate the impact of channel estimation errors on different spatial-temporal transmission schemes. The channel estimation errors are modeled by an zero mean complex Gaussian matrix. We then study the error floors of several transmission schemes, namely the Alamouti scheme, spatial multiplexing (SM) and the hybrid scheme. Our study reveals that for small estimation error, the Alamouti scheme has lower error floor comparing to the SM, while for 4 transmit antennas, the hybrid scheme is more robust than the pure SM. Moreover, simulation results show that the hybrid scheme with antenna shuffling can lower the error floor even further.
Television viewing, television content, food intake, physical activity and body mass index: a cross-sectional study of preschool children aged 2-6 years.

ISSUE ADDRESSED The mechanisms underlying the relationship between television (TV) viewing and weight status in preschool aged children are not well understood. This study aimed to explore the relationships between preschool children's TV viewing habits (i.e. time spent viewing, content watched and foods eaten while viewing), daily food intake, general physical activity levels and their body mass index (BMI). METHOD A cross-sectional sample of preschool children in Melbourne (n = 135). Mothers of preschoolers completed a 3-day TV diary; information was collected on viewing time, content and food consumed while watching TV. Mothers also reported their child's height, weight and physical activity behaviour. Associations between study and outcome variables were determined by bivariate correlations and hierarchical regression analyses. RESULTS Mean age of preschoolers was 4.5 years and 14% were overweight or obese. The mean daily time spent watching TV was 90.7 minutes (SD 50.7) A small, positive correlation was found between viewing TV on weekdays and child BMIz, (p<0.05). This effect was moderate when controlled for total kilojoules consumed while watching TV (on weekdays) and number of minutes spent in sedentary activities (across three days). CONCLUSIONS This study suggests that TV viewing may affect preschool child weight status through displacement of physical activity or eating while viewing.
Repeated gamma knife surgery for multiple brain metastases from renal cell carcinoma.

OBJECT The aim of this study was to evaluate the therapeutic profile of repeated gamma knife surgery (GKS) for renal cell carcinoma that has metastasized to the brain on multiple occasions. METHODS Data from this study were culled from a single institution and cover a 6-year period of outpatient radiosurgery. A standard protocol for indication, dose planning, and follow up was established. In cases of distant or local recurrences, radiosurgery was undertaken repeatedly (up to six times in one individual). Seventy-five patients harboring 350 cerebral metastases were treated. Relief from pretreatment neurological symptoms occurred in 72% of patients within a few days or a few weeks after the procedure. The actuarial local tumor control rate after the initial GKS was 95%. In patients free from relapse of intracranial metastases after repeated radiosurgery, long-term survival was 91% after 4 years; median survival was 11.1+/-3.2 months after radiosurgery and 4.5+/-1.1 years after diagnosis of the primary kidney cancer. Survival following radiosurgery was independent of patient age and sex, side of the renal cell carcinoma, pretreatment of the cerebrum by using radiotherapy or surgery, number of brain metastases and their synchronization with the primary renal cell carcinoma, and the frequency of radiosurgical procedures. In contrast, survival was dependent on the patient's clinical performance score and the extracranial tumor status. Tumor bleeding was observed in seven patients (9%) and late radiation toxicity (LRT) in 15 patients (20%). Treatment-related morbidity was moderate and mostly transient. Late radiation toxicity was encountered predominantly in long-term survivors. CONCLUSIONS Outpatient repeated radiosurgery is an effective and only minimally invasive treatment for multiple brain metastases from renal cell cancer and is recommended as being the method of choice to control intracranial disease, especially in selected patients with limited extracranial disease. Physicians dealing with such patients should be aware of the characteristic aspects of LRT.
FGF-FGFR Mediates the Activity-Dependent Dendritogenesis of Layer IV Neurons during Barrel Formation

Fibroblast growth factors (FGFs) and FGF receptors (FGFRs) are known for their potent effects on cell proliferation/differentiation and cortical patterning in the developing brain. However, little is known regarding the roles of FGFs/FGFRs in cortical circuit formation. Here we show that Fgfr1/2/3 and Fgf7/9/10/22 mRNAs are expressed in the developing primary somatosensory (S1) barrel cortex. Barrel cortex layer IV spiny stellate cells (bSCs) are the primary recipients of ascending sensory information via thalamocortical axons (TCAs). Detail quantification revealed distinctive phases for bSC dendritogenesis: orienting dendrites toward TCAs, adding de novo dendritic segments, and elongating dendritic length, while maintaining dendritic patterns. Deleting Fgfr1/2/3 in bSCs had minimal impact on dendritic polarity but transiently increased the number of dendritic segments. However, 6 d later, FGFR1/2/3 loss of function reduced dendritic branch numbers. These data suggest that FGFs/FGFRs have a role in stabilizing dendritic patterning. Depolarization of cultured mouse cortical neurons upregulated the levels of several Fgf/Fgfr mRNAs within 2 h. In vivo, within 6 h of systemic kainic acid administration at postnatal day 6, mRNA levels of Fgf9, Fgf10, Fgfr2c, and Fgfr3b in S1 cortices were enhanced, and this was accompanied by exuberant dendritogenesis of bSCs by 24 h. Deleting Fgfr1/2/3 abolished kainic acid-induced bSC dendritic overgrowth. Finally, FGF9/10 gain of function also resulted in extensive dendritogenesis. Together, our data suggest that FGFs/FGFRs can be regulated by glutamate transmission to modulate/stabilize bSC dendritic complexity. Both male and female mice were used for our study. SIGNIFICANCE STATEMENT Glutamatergic transmission plays critical roles in cortical circuit formation. Its dysregulation has been proposed as a core factor in the etiology of many neurological diseases. We found that excessive glutamate transmission upregulated mRNA expression of Fgfrs and their ligands Fgfs. Deleting Fgfr1/2/3 not only impaired bSC dendritogenesis but also abolished glutamate transmission-induced dendritic overgrowth. Overexpressing FGF9 or FGF10 in cortical glutamatergic neurons results in excessive dendritic outgrowth within 24 h, resembling the changes induced by excessive glutamate transmission. Our findings provide strong evidence for the physiological role of fibroblast growth factors (FGFs) and FGF receptors (FGFRs) in establishing and maintaining cortical circuits. Perturbing the expression levels of FGFs/FGFRs by excessive glutamatergic neurotransmission could lead to abnormal neuronal circuits, which may contribute to neurological and psychiatric disease.