Miracle-dz/UniFAR-FTUs huggingface dataset:
Early Adolescent Patterns of Alcohol and Tobacco Use in Eight Association of South-East Asian Nations (ASEAN) Member States

Abstract Background: Though alcohol and tobacco are the most commonly used substances among adolescents, little is known about the patterning of early adolescent substance use in Association of South-East Asian Nations (ASEAN) member states. Objectives: This study examined past month patterns of substances use and its gender difference among adolescents. Methods: Cross-sectional samples among adolescents aged 13–16 years who completed the Global School-based Student Health Survey (GSHS) from eight ASEAN countries were included in the analysis (n = 40,212). Results: Prevalence of past month any tobacco use was relatively high in Brunei, Indonesia, Malaysia, Thailand, and the Philippines (11–15%), but prevalence of dual cigarette and other forms of tobacco use was about 2–5% in the five countries. Past month alcohol consumption prevalence was also high in Thailand, Viet Nam, and the Philippines (16–24%), compared to the rest countries (1.4–8.2%). Moreover, prevalence of the concurrent alcohol and tobacco use was higher in Thailand and the Philippines (7 and 10%, respectively), particularly in boys (13 and 15%, respectively). Conclusions/importance: Almost 30–40% of the boys and 10–20% of girls in Malaysia, Philippines, Thailand, and Viet Nam are engaged in at least one of the two risk behaviors, and the concurrent alcohol and tobacco use was also relatively high among boys in those countries (5–15%). This study may provide some valuable insights on alcohol and tobacco policy in the region and requires to begin prevention and treatment programs in ASEAN member states.
Texting for Help: Processes and Impact of Text Counseling with Children and Youth with Suicide Ideation.

OBJECTIVE To explore: (1) how children contacting a child helpline with suicide ideation differ from children discussing other topics, (2) whether text messaging effectively helps, and (3) which counselor behaviors are most effective. METHOD Of 6,060 text sessions at the Danish national child helpline, 444 concerned suicidality, of which the 102 sessions that included self-rated, end Session ratings were selected for content analysis. RESULTS Twenty-six percentage of suicidal children had severe suicidality. The suicide sample had significantly more girls, was older than the nonsuicide sample, and more often recontacted the helpline in the 2 weeks prior to follow-up. 35.9% of suicidal children felt better immediately and over half ended the session with a plan of action. At follow-up, 23.9% of suicidal children reported feeling better; however, 37.0% reported feeling worse. Talking about emotions, expressing empathy, and encouraging the child to talk to someone were associated with positive impacts. Setting boundaries was associated with negative impacts. CONCLUSIONS Texting with suicidal children can be helpful, but should be considered a first step toward obtaining more sustainable help. Research is needed to determine how to better help children who felt worse or did not improve in the 2 weeks after contacting the helpline. Suggestions to further training of counselors are discussed.
Novel Factors of Viral Origin Inhibit TOR Pathway Gene Expression

Polydnaviruses (PDVs) are obligate symbionts of endoparasitoid wasps, which exclusively attack the larval stages of their lepidopteran hosts. The Polydnavirus is injected by the parasitoid female during oviposition to selectively infect host tissues by the expression of viral genes without undergoing replication. Toxoneuron nigriceps bracovirus (TnBV) is associated with Toxoneuron nigriceps (Hymenoptera: Braconidae) wasp, an endoparasitoid of the tobacco budworm larval stages, Heliothis virescens (Lepidoptera: Noctuidae). Previous studies showed that TnBV is responsible for alterations in host physiology. The arrest of ecdysteroidogenesis is the main alteration which occurs in last (fifth) instar larvae and, as a consequence, prevents pupation. TnBV induces the functional inactivation of H. virescens prothoracic glands (PGs), resulting in decreased protein synthesis and phosphorylation. Previous work showed the involvement of the PI3K/Akt/TOR pathway in H. virescens PG ecdysteroidogenesis. Here, we demonstrate that this cellular signaling is one of the targets of TnBV infection. Western blot analysis and enzyme immunoassay (EIA) showed that parasitism inhibits ecdysteroidogenesis and the phosphorylation of the two targets of TOR (4E-BP and S6K), despite the stimulation of PTTH contained in the brain extract. Using a transcriptomic approach, we identified viral genes selectively expressed in last instar H. virescens PGs, 48 h after parasitization, and evaluated expression levels of PI3K/Akt/TOR pathway genes in these tissues. The relative expression of selected genes belonging to the TOR pathway (tor, 4e-bp, and s6k) in PGs of parasitized larvae was further confirmed by qRT-PCR. The down-regulation of these genes in PGs of parasitized larvae supports the hypothesis of TnBV involvement in blocking ecdysteroidogenesis, through alterations of the PI3K/Akt/TOR pathway at the transcriptional level.
Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis

Aberrant hepatocyte Notch activation is required for development of NASH-associated fibrosis, and Notch inhibition ameliorates obesity-induced liver disease. Taking liver fibrosis down a Notch Nonalcoholic steatohepatitis (NASH) is a liver disease characterized by fat accumulation, inflammation, and liver cell damage. Here, Zhu et al. focused on Notch signaling in NASH and associated liver fibrosis. Expression of Notch target genes was increased in liver biopsies from patients with more severe NASH, and a mouse model of diet-induced NASH showed increased hepatocyte Notch expression. Notch signaling activated hepatic stellate cells, leading to liver fibrosis. Inhibiting Notch signaling using a liver-targeted antisense oligonucleotide reduced liver fibrosis in a diet-induced NASH mouse model. This study suggests that targeting hepatocyte Notch signaling could be therapeutic for NASH-associated liver fibrosis. Fibrosis is the major determinant of morbidity and mortality in patients with nonalcoholic steatohepatitis (NASH) but has no approved pharmacotherapy in part because of incomplete understanding of its pathogenic mechanisms. Here, we report that hepatocyte Notch activity tracks with disease severity and treatment response in patients with NASH and is similarly increased in a mouse model of diet-induced NASH and liver fibrosis. Hepatocyte-specific Notch loss-of-function mouse models showed attenuated NASH-associated liver fibrosis, demonstrating causality to obesity-induced liver pathology. Conversely, forced activation of hepatocyte Notch induced fibrosis in both chow- and NASH diet–fed mice by increasing Sox9-dependent Osteopontin (Opn) expression and secretion from hepatocytes, which activate resident hepatic stellate cells. In a cross-sectional study, we found that OPN explains the positive correlation between liver Notch activity and fibrosis stage in patients. Further, we developed a Notch inhibitor [Nicastrin antisense oligonucleotide (Ncst ASO)] that reduced fibrosis in NASH diet–fed mice. In summary, these studies demonstrate the pathological role and therapeutic accessibility of the maladaptive hepatocyte Notch response in NASH-associated liver fibrosis.
Estimation of the standardized ileal digestible lysine requirement and optimal sulphur amino acids to lysine ratio for 30–50 kg pigs

Two experiments were conducted to determine the standardized ileal digestible (SID) lysine (Lys) requirement and the ideal SID sulphur amino acids (SAA) to Lys ratio for 30-50 kg crossbred pigs. In experiment 1, a total of 72 crossbred pigs with an average initial body weight (BW) of 28.9 kg were allotted to one of six dietary treatments in a randomized complete block design. Each diet was assigned to six pens containing two pigs each. Six diets were obtained by supplementing graded levels of L-Lysine∙HCl to create six dietary levels of SID Lys (0.70%, 0.80%, 0.90%, 1.00%, 1.10% and 1.20%). Responses of weight gain (ADG) and gain:feed (G:F) to increasing the SID Lys content of the diet fitted well with the curvilinear-plateau model; whereas, for plasma urea nitrogen (PUN) two-slope linear broken-line model was well fitted. The optimal SID Lys requirement for the pigs of this period was 1.10%. Experiment 2 was a dose-response study using SID Met+Cys to Lys ratios of 50%, 55%, 60%, 65%, 70% and 64%. A total of 72 crossbred pigs with initial BW of 32.9 kg were randomly allotted to receive one of the six diets. Diets 1-5 were formulated to contain 1.0% SID Lys to be second limiting in Lys and diet 6 contained 1.11% SID Lys to be adequate in Lys. The average optimal SID SAA:Lys ratio for maximal ADG and G:F and minimal PUN was 65.2% using curvilinear-plateau and linear broken-line models.
Effect of Accommodating Elastic Bands on Mechanical Power Output during Back Squats

The aim of this study was to investigate whether accommodating elastic bands with barbell back squats (BSQ) increase muscular force during the deceleration subphase. Ten healthy men (mean ± standard deviation: Age: 23 ± 2 years; height: 170.5 ± 3.7 cm; mass: 66.7 ± 5.4 kg; and BSQ one repetition maximum (RM): 105 ± 23.1 kg; BSQ 1RM/body mass: 1.6 ± 0.3) were recruited for this study. The subjects performed band-resisted parallel BSQ (accommodating elastic bands each sides of barbell) with five band conditions in random order. The duration of the deceleration subphase, mean mechanical power, and the force and velocity during the acceleration and deceleration subphases were calculated. BSQ with elastic bands elicited greater mechanical power output, velocity, and force during the deceleration subphase, in contrast to that elicited with traditional free weight (p < 0.05). BSQ with elastic bands also elicited greater mechanical power output and velocity during the acceleration subphase. However, the force output during the acceleration subphase using an elastic band was lesser than that using a traditional free weight (p < 0.05). This study suggests that BSQ with elastic band elicit greater power output during the acceleration and deceleration subphases.
Transferable Interactiveness Prior for Human-Object Interaction Detection

Human-Object Interaction (HOI) Detection is an important problem to understand how humans interact with objects. In this paper, we explore Interactiveness Prior which indicates whether human and object interact with each other or not. We found that interactiveness prior can be learned across HOI datasets, regardless of HOI category settings. Our core idea is to exploit an Interactiveness Network to learn the general interactiveness prior from multiple HOI datasets and perform Non-Interaction Suppression before HOI classification in inference. On account of the generalization of interactiveness prior, interactiveness network is a transferable knowledge learner and can be cooperated with any HOI detection models to achieve desirable results. We extensively evaluate the proposed method on HICO-DET and V-COCO datasets. Our framework outperforms state-of-the-art HOI detection results by a great margin, verifying its efficacy and flexibility. Source codes and models will be made publicly available.
Investigating the Utility of Fixed-margin Sampling in Network Psychometrics

Abstract Steinley, Hoffman, Brusco, and Sher (2017) proposed a new method for evaluating the performance of psychological network models: fixed-margin sampling. The authors investigated LASSO regularized Ising models (eLasso) by generating random datasets with the same margins as the original binary dataset, and concluded that many estimated eLasso parameters are not distinguishable from those that would be expected if the data were generated by chance. We argue that fixed-margin sampling cannot be used for this purpose, as it generates data under a particular null-hypothesis: a unidimensional factor model with interchangeable indicators (i.e., the Rasch model). We show this by discussing relevant psychometric literature and by performing simulation studies. Results indicate that while eLasso correctly estimated network models and estimated almost no edges due to chance, fixed-margin sampling performed poorly in classifying true effects as “interesting” (Steinley et al. 2017, p. 1004). Further simulation studies indicate that fixed-margin sampling offers a powerful method for highlighting local misfit from the Rasch model, but performs only moderately in identifying global departures from the Rasch model. We conclude that fixed-margin sampling is not up to the task of assessing if results from estimated Ising models or other multivariate psychometric models are due to chance.
Reduced lateral orbitofrontal cortex volume and suicide behavior in youth with bipolar disorder

Structural abnormalities in cortical and subcortical regions, including the orbitofrontal cortex (OFC), are altered during brain development in adolescents with bipolar disorder (BD), which may increase risk for suicide. Few studies have examined the neural substrates of suicidal behavior in BD youth. The aim of the present study was to investigate the relationship between suicide behavior and the OFC in youth with BD.
A Survey-Based Investigation of Human Factors Associated With Transport Related Injuries in Horses

Injuries resulting from road transport are common in horses and are a potential welfare concern, as well as, a source of economic loss. An online cross sectional survey was used to determine the prevalence of road transport related injuries to horses in New Zealand and the association of human factors including demographics, industry background, training and the horse handling experience of the respondents with transport related injury. The survey generated 1133 valid responses that were analyzed using descriptive statistics, univariate and multivariate logistic regression analysis. At least one injured horse was reported by 201/1133 (17.7%) respondents as occurring during the two previous years. Only 191 respondents chose to provide further information on when the injury occurred and most injuries (133/191; 69.6%) occurred in transit. The respondent perceived possible reason for injury was reported by 190, and was most frequently thought to be either horse-associated (87/190; 45.8%) or associated with a driver mistake (18/190; 9.5%). Variables that remained as significantly associated with injury in a multivariate model focusing on human factors were experience in horse handling, the industry sector, and the amateur or professional involvement with the horse industry. The odds of injury associated with professionals may reflect greater exposure due to more frequent transport and larger numbers of horses in their care than amateurs. Findings confirm that human factors are associated with the risk of an injury during transport. Although further studies are required to determine if any of these relationships are causative, education on transport best practices with consideration of these factors may mitigate their influence.
Data Mining Techniques in Analyzing Process Data: A Didactic

Due to increasing use of technology-enhanced educational assessment, data mining methods have been explored to analyse process data in log files from such assessment. However, most studies were limited to one data mining technique under one specific scenario. The current study demonstrates the usage of four frequently used supervised techniques, including Classification and Regression Trees (CART), gradient boosting, random forest, support vector machine (SVM), and two unsupervised methods, Self-organizing Map (SOM) and k-means, fitted to one assessment data. The USA sample (N = 426) from the 2012 Program for International Student Assessment (PISA) responding to problem-solving items is extracted to demonstrate the methods. After concrete feature generation and feature selection, classifier development procedures are implemented using the illustrated techniques. Results show satisfactory classification accuracy for all the techniques. Suggestions for the selection of classifiers are presented based on the research questions, the interpretability and the simplicity of the classifiers. Interpretations for the results from both supervised and unsupervised learning methods are provided.
PTPRF as a novel tumor suppressor through deactivation of ERK1/2 signaling in gastric adenocarcinoma

Background Protein tyrosine phosphatase, receptor type F (PTPRF) is an important phosphatase playing roles in regulating cell growth, differentiation and oncogenic transformation. Overexpression of PTPRF has been observed in non-small cell lung cancer, but its clinical significance in other malignancies is still unknown. Methods We explored the expression pattern of PTPRF in gastric adenocarcinoma by using RT-qPCR and immunohistochemistry staining. The clinical significance of PTPRF was evaluated by univariate and multivariate analyses. Furthermore, the signaling pathways downstream of PTPRF was investigated by knockdown and overexpression assays combined with cellular studies. Results We found a remarkable down-regulation of PTPRF in gastric adenocarcinomas, which was significantly associated with advanced tumor TNM stages. Survival analysis showed that lower PTPRF level indicated a poorer overall survival of gastric adenocarcinoma patients. By conducting knockdown and overexpression studies in gastric adenocarcinoma cells, we revealed the role of PTPRF on inhibiting extracellular signal-regulated kinase-1/2 (ERK1/2) phosphorylation and its downstream signaling. Consistent with clinical findings, cellular results demonstrated that overexpressing PTPRF can significantly inhibit tumor migration and invasion, while silencing PTPRF showed opposite effects. Conclusion In conclusion, patients with lower PTPRF expression in gastric adenocarcinoma tissues were more predisposed to advanced tumor stage and unfavorable prognosis.
A Comparison of Lucene Search Queries Evolved as Text Classifiers

ABSTRACT In this article, we use a genetic algorithm to evolve seven different types of Lucene search query with the objective of generating accurate and readable text classifiers. We compare the effectiveness of each of the different types of query using three commonly used text datasets. We vary the number of words available for classification and compare results for 4, 8, and 16 words per category. The generated queries can also be viewed as labels for the categories and there is a benefit to a human analyst in being able to read and tune the classifier. The evolved queries also provide an explanation of the classification process. We consider the consistency of the classifiers and compare their performance on categories of different complexities. Finally, various approaches to the analysis of the results are briefly explored.
Quality Adaptation Algorithm for Streaming over CoAP

This paper presents a quality adaptation algorithm for multimedia streaming over constrained application protocol (CoAP) in the Internet of Things (IoT) environment. The proposed scheme is designed to improve user experience by meeting the video quality objectives in a constrained wireless environment. To achieve this, the proposed scheme increases or decreases the video quality by taking the throughput of the available wireless link and segment download time into consideration. The algorithm decides to aggressively or conservatively increase the video quality based on the sizes of the upcoming segments. In addition, the algorithm decreases the video rate by predicting the buffer level at the download of the next segment. The results show that the proposed algorithm improves user experience by achieving high quality video and mitigating the risk of playback interruptions.
Exercise performance increase in smokeless tobacco‐user athletes after overnight nicotine abstinence

The use of nicotine administered through smokeless tobacco (snus) has increased among athletes. The purpose of this study was to investigate the ergogenic effects of snus on aerobic performance during exercise until exhaustion in athletes after abstinence or satiety nicotine conditions. The study utilized a randomized, controlled, within‐subject design experiment. Sixteen male snus‐user athletes completed an exercise until exhaustion at a constant load of their 80% of V˙O2max (calculated by a maximal incremental test) in two separate sessions, corresponding to nicotine conditions: 12‐hour overnight abstinence and satiety. A portion of 1 g of snus (~8 mg/g of nicotine) was administered 25 minutes before each experimental test. In each session, time to exhaustion (TTE), global rating of perceived exertion, cardiovascular and metabolic responses, and muscle and cerebral oxygenation were measured. Nicotine and cotinine analysis confirmed session conditions (abstinence or satiety). Snus induced a significant increase (+13.1%) of TTE following abstinence (24.1 ± 10.7 minutes) compared to satiety condition (20.9 ± 8.0 minutes; P = 0.0131). The baseline values revealed that abstinence of snus induced significant increase in the oxygenation of the muscular tissues (+4%), in metabolic values and in cardiovascular parameters, when compared to satiety condition. Our results indicate an increase of exercise performance (+13.1% TTE) due to snus administration in an abstinence condition. Considering that twelve hours of abstinence from snus‐contained nicotine affected metabolic, cardiovascular and muscular tissue oxygenation, we suggest that snus administration at test time might relieve these withdrawal changes and yield an increase in time to exhaustion.
Some Subsystems of Constant-Depth Frege with Parity

We consider three relatively strong families of subsystems of AC0[2]-Frege proof systems, i.e., propositional proof systems using constant-depth formulas with an additional parity connective, for which exponential lower bounds on proof size are known. In order of increasing strength, the subsystems are (i) constant-depth proof systems with parity axioms and the (ii) treelike and (iii) daglike versions of systems introduced by Krajíček which we call PKcd(⊕). In a PKcd(⊕)-proof, lines are disjunctions (cedents) in which all disjuncts have depth at most d, parities can only appear as the outermost connectives of disjuncts, and all but c disjuncts contain no parity connective at all. We prove that treelike PKO(1)O(1)(⊕) is quasipolynomially but not polynomially equivalent to constant-depth systems with parity axioms. We also verify that the technique for separating parity axioms from parity connectives due to Impagliazzo and Segerlind can be adapted to give a superpolynomial separation between daglike PKO(1)O(1)(⊕) and AC0[2]-Frege; the technique is inherently unable to prove superquasipolynomial separations. We also study proof systems related to the system Res-Lin introduced by Itsykson and Sokolov. We prove that an extension of treelike Res-Lin is polynomially simulated by a system related to daglike PKO(1)O(1)(⊕), and obtain an exponential lower bound for this system.