Miracle-dz/UniFAR-FTUs huggingface dataset:
Mucinous tumours of the ovary

Mucinous epithelial ovarian cancers (mEOC) are a relatively rare subset of ovarian cancers. Despite a relatively favourable outcome in early disease, the more frequent advanced presentation is associated with poorer response to platinum/taxane chemotherapies, and poorer survival, compared to serous ovarian cancers. We consider some of the fundamental clinico-pathological and molecular features, and existing clinical trial data regarding mEOC. Underlying molecular differences, between mEOC and serous cancers may contribute to the observed clinical differences, including an increased prevalence of K-RAS mutations in mEOC, more in keeping with gastrointestinal tumours. This observation contributes to the rationale for a trial (“mEOC”) investigating the use of “ovarian” versus “gastrointestinal” style chemotherapy. Looking to potential future approaches, we speculate upon the potential impact of emerging technologies on the future investigation and management of mEOC.
Profiling of MicroRNAs Involved in Retinal Degeneration Caused by Selective Müller Cell Ablation

Dysfunction of Müller cells has been implicated in the pathogenesis of several retinal diseases. In order to understand the potential contribution of Müller cells to retinal disease better, we have developed a transgenic model in which foci of Müller cell ablation can be selectively induced. MicroRNAs (miRNAs), small non-coding RNAs that are involved in post-transcriptional modulation, have critical functions in various biological processes. The aim of this study was to profile differential expression of miRNAs and to examine changes in their target genes 2 weeks after Müller cell ablation. We identified 20 miRNAs using the miScript HC PCR array. Data analysis using two target gene prediction databases (TargetScan and mirTarBase) revealed 78 overlapping target genes. DAVID and KEGG pathway analysis suggested that the target genes were generally involved in cell apoptosis, p53, neurotrophin, calcium, chemokine and Jak-STAT signalling pathways. Changes in seven target genes including Cyclin D2, Caspase 9, insulin-like growth factor 1, IL-1 receptor-associated kinase (IRAK), calmodulin (CALM) and Janus kinase 2 (Jak2), were validated with qRT-PCR and western blots. The cellular localisation of cleaved-caspase 9, Cyclin D2, Jak2 and CALM was examined by immunofluorescence studies. We found that the transcription of some miRNAs was positively, rather than negatively, correlated with their target genes. After confirming that overexpressed miR-133a-3p was localised to the outer nuclear layer in the damaged retina, we validated the correlation between miR-133a-3p and one of its predicted target genes, cyclin D2, with a luciferase assay in 661 photoreceptor cells. Results revealed by miRNA profiling, target gene analysis and validation were generally consistent with our previous findings that selective Müller cell ablation causes photoreceptor degeneration and neuroinflammation. Our data on alterations of miRNAs and their target gene expression after Müller cell ablation provide further insights into the potential role of Müller cell dysfunction in retinal disease.
Efficacy and Cost Effectiveness of Therapeutic Plasma Exchange in patient of Guillain-Barre Syndrome – A Prospective study -

Introduction: Guillain-Barre syndrome (GBS) is an acute, frequently severe, fulminant poly-radiculoneuropathy that is autoimmune in nature. Current treatment modalities include therapeutic plasma exchange (TPE) and high dose intravenous Immunoglobulin therapy (I.V Ig), both of which involve a high cost. Objectives: To compare the cost effectiveness of plasma exchange over other modalities and to evaluate the clinical benefits of plasma exchange GBS patients. Discussion: In the present study, 100 patients (56 males and 44 females) admitted to the Civil Hospital, Ahmedabad from September 2010 to August 2012 with clinical findings of GBS and/or GBS variants were evaluated. Plasma was exchanged using a Baxter-CS 3000 continuous flow cell separator using double lumen femoral catheter, until a plasma discard of 50ml/kg had been achieved. Cost of treatment with plasma exchange for each patient was compared with other available modalities. Incidence of GBS was found to be more in 11-30 years age group. Male to female ratio was 1.27: 1. Most of the patients underwent 3 cycles of exchange. The result of plasma exchange in terms of improvement in clinical condition of patient was Excellent i.e. more than 85% in 82 patients. No complication was seen in 62 patients and minor complications were observed in 21 patients. The cost of plasma exchange and immunoglobulin treatment were came out to be approximately Rs 30,000/- and Rs. 1, 74,000/- in each patient respectively. Conclusion: Plasma exchange proved to be a better and less costly in the treatment of GBS patient if performed in the first two weeks of onset.
Langue étrangère et français en milieu scolaire : Didactiser l'alternance ?

Les classes de langue etrangere de l'enseignement secondaire constituent des micro-societes au sein desquelles tous les acteurs recourent largement a la langue source dans les echanges. Les changements de langues qui se developpent dans un tel contexte remplissent des fonctions essentielles dans la co-construction du sens, fonctions qui ne sont que rarement explicitees dans les classes. C'est au moyen d'un travail en direction des enseignants que l'on propose d'avancer vers une utilisation raisonnee de ces procedes.
Compositional verification of real-time systems

Presents a compositional proof system for the verification of real-time systems. Real-time systems are modeled as timed transition modules, which explicitly model interaction with the environment and may be combined using composition operators. Composition rules are devised such that the correctness of a system may be determined from the correctness of its components. These proof rules are demonstrated on Fischer's mutual exclusion algorithm, for which mutual exclusion and bounded response are proven. <<ETX>>
Evolución mensual en campo de las ectomicorrizas de Tuber melanosporum Vitt. inoculadas en plantas de Quercus ilex

El seguimiento de las micorrizas de Tuber melanosporum Vitt. puede ayudar a predecir el exito de una plantacion trufera, por ello es importante saber la mejor epoca del ano para hacer este seguimiento. El objetivo del estudio es conocer la evolucion mensual del estado y el numero total de apices de T. melanosporum en plantas de Quercus ilex inoculadas con este hongo. Cada mes hemos extraido plantas enteras del campo y hemos contado el numero de micorrizas de trufa o de otros hongos y el numero de apices no micorricicos. Los meses de julio a octubre han sido los meses en los que hemos observado un menor numero de apices de T. melanosporum. No obstante, durante todos los meses del ano se han contabilizado apices jovenes y viejos de trufa negra.
Pro-Environmental Spillover Review of Research on the Different Pathways Through Which Performing One Pro-Environmental Behaviour Can Influence the Likelihood of Performing Another

This report presents a review of the literature that underpins the different pathways through which the transition between two pro-environmental behaviours can occur. Its primary aim is to inform the theoretical part of a 2012 linkage project grant application for the Australian Research Council to be submitted by BehaviourWorks Australia. A special emphasis is on research where interventions have been empirically tested on the basis of one of the pathways between behaviours. Where such research is absent, purely theoretical or correlational is used to fill the gaps. However, if there is applied research to support (or not) a particular pathway, then this research is emphasized.
Miocene shallow-water carbonates on the Eratosthenes Seamount, easternmost Mediterranean Sea

Miocene shallow-water limestones of the Eratosthenes Seamount add considerably to the picture of widespread and heterogeneous Mediterranean Miocene reef development. Shallow-water limestones were cored at two sites on the Eratosthenes Seamount during Ocean Drilling Program Leg 160, one on the plateau area and one on the upper northern slopes. The limestones at Site 966 are dated as Miocene by use of benthic foraminifers, whereas those at Site 965, although lacking diagnostic fossils, are inferred to be of late Miocene age from the evidence of preliminary strontium isotopic dating. At Site 966, shallow-water limestones are underlain by upper Eocene bathyal pelagic carbonates and overlain by a mass-flow unit of early Pliocene age; by contrast, at Site 965, paleosols, of assumed Messinian age, overlie the Miocene limestones.
Corporate Governance in Germany: An Economic Perspective

A financial system can only perform its function of channelling funds from savers to investors if it offers sufficient assurance to the providers of the funds that they will reap the rewards which have been promised to them. To the extent that this assurance is not provided by contracts alone, potential financiers will want to monitor and influence managerial decisions. This is why corporate governance is an essential part of any financial system. It is almost obvious that providers of equity have a genuine interest in the functioning of corporate governance. However, corporate governance encompasses more than investor protection. Similar considerations also apply to other stakeholders who invest their resources in a firm and whose expectations of later receiving an appropriate return on their investment also depend on decisions at the level of the individual firm which would be extremely difficult to anticipate and prescribe in a set of complete contingent contracts. Lenders, especially long-term lenders, are one such group of stakeholders who may also want to play a role in corporate governance; employees, especially those with high skill levels and firm-specific knowledge, are another. The German corporate governance system is different from that of the Anglo-Saxon countries because it foresees the possibility, and even the necessity, to integrate lenders and employees in the governance of large corporations. The German corporate governance system is generally regarded as the standard example of an insider-controlled and stakeholder-oriented system. Moreover, only a few years ago it was a consistent system in the sense of being composed of complementary elements which fit together well. The first objective of this paper is to show why and in which respect these characterisations were once appropriate. However, the past decade has seen a wave of developments in the German corporate governance system, which make it worthwhile and indeed necessary to investigate whether German corporate governance has recently changed in a fundamental way. More specifically one can ask which elements and features of German corporate governance have in fact changed, why they have changed and whether those changes which did occur constitute a structural change which would have converted the old insider-controlled system into an outsider-controlled and shareholder-oriented system and/or would have deprived it of its former consistency. It is the second purpose of this paper to answer these questions.
Natural optical activity and its control by electric field in electrotoroidic systems

This work is financially supported by ONR Grants No. N00014-11-1-0384, No. 00014-12-1-1034, and No. N00014-08-1-0915 (S.P. and L.B., for contributing to analytical derivations and phenomenology), ARO Grant No. W911NF-12-1- 0085 (Z.G. and L.B. for atomistic simulations under ac fields), and NSF Grant No. DMR-1066158 (L.L., R.W., and L.B for some effective Hamiltonian computations). I.S. acknowledges support from Grant No. MAT2012-33720 from the Spanish Ministerio de Economia y Competitividad. S.P. appreciates Grant No. 12-08-00887-a from the Russian Foundation for Basic Research. L.B. also acknowledges discussions with scientists sponsored by the Department of Energy, Office of Basic Energy Sciences, under Contract No. ER-46612, Javier Junquera, Pablo Aguado-Puente, and Surendra Singh.
Anatomical Placement of the Human Eyeball in the Orbit—Validation Using CT Scans of Living Adults and Prediction for Facial Approximation *

Abstract: Accuracy of forensic facial approximation and superimposition techniques relies on the knowledge of anatomical correlations between soft and hard tissues. Recent studies by Stephan and collaborators (6,8,10) reviewed traditional guidelines leading to a wrong placement of the eyeball in the orbit. As those statements are based on a small cadaver sample, we propose a validation of these findings on a large database (n = 375) of living people. Computed tomography scans of known age and sex subjects were used to collect landmarks on three‐dimensional surfaces and DICOM with TIVMI. Results confirmed a more superior and lateral position of the eyeball relatively to the orbital rims. Orbital height and breadth were used to compute regression formulae and proportional placement using percentages to find the most probable position of the eyeball in the orbit. A size‐related sexual dimorphism was present but did not impact on the prediction accuracy.
Performance Study of a UWB Antenna in Proximity to a Human Arm

This letter studies the frequency- and time-domain performance of a recently developed printed coplanar-fed ultrawideband (UWB) monopole antenna aiming at predicting its behavior close to a human arm. The input reflection coefficient <formula formulatype="inline"><tex Notation="TeX">$(\vert{ S}_{11}\vert)$</tex></formula> and fidelity factor of the antenna were evaluated in free space and close to an arm. Simulations using three simplified arm models with different cross sections (flat, rectangular, and elliptical) were compared to measurements. All models include the relevant human tissue layers: skin, fat, muscle, and bone. It was found that an accurate model requires the inclusion of the tissues broadband dispersion characterization. Moreover, the skin layer has a major impact in <formula formulatype="inline"><tex Notation="TeX">$\vert{S}_{11}\vert$</tex> </formula>, and a small effect on fidelity, while the models can be simplified by discarding the bone. Furthermore, the geometry of the models is less relevant than dispersion characterization. It has also been observed that using the simplified models with proper broadband tissues dispersion yields good performance predictions, and that the fidelity factor increases as the antenna gets closer to the arm.
Hybrid attitude tracking of output feedback controlled rigid bodies

In this paper we address the problem of output feedback attitude control of a rigid body in quaternion coordinate space through a PD+ based tracking controller using switching technique to obtain stability for all initial values. Assumptions on earlier results where either the initial state is considered bounded, or the attitude error for all time is less than 180 degrees, is removed by applying switching technique, also including hysteresis for robust stability. More precisely, we show uniform asymptotic stability in the large of a set containing the origin for the closed-loop system in the presence of unknown, bounded input disturbances. Simulation results are presented to verify our theoretical findings, showing that the system stabilizes as expected, even with high initial estimated velocity error.
Food Habits and Selective Foraging by the Texas River Cooter (Pseudemys texana) in Spring Lake, Hays County, Texas

Abstract The fall-winter food habits of the Texas river cooter (Pseudemys texana) were investigated at Spring Lake, Hays County, Texas, by examination of stomach contents. Samples were collected from 33 live turtles by flushing stomach contents with water (Fields et al., 2000). Four aquatic macrophytes composed 91.6% of the diet. Aquatic macrophyte availability at Spring Lake was estimated using the Daubenmire technique (Daubenmire and Daubenmire, 1968) and compared to occurrence in the diet to assess selectivity in foraging. Cooters actively selected Carolina fanwort (Cabomba caroliniana), a plant low in fiber and high in total digestible nutrients. Hydrilla (Hydrilla verticilata), an invasive exotic aquatic plant, was an important food item due to the large amount present in the lake.
Fuzzy Finite-Time Command Filtered Control of Nonlinear Systems With Input Saturation

This paper considers the fuzzy finite-time tracking control problem for a class of nonlinear systems with input saturation. A novel fuzzy finite-time command filtered backstepping approach is proposed by introducing the fuzzy finite-time command filter, designing the new virtual control signals and the modified error compensation signals. The proposed approach not only holds the advantages of the conventional command-filtered backstepping control, but also guarantees the finite-time convergence. A practical example is included to show the effectiveness of the proposed method.
Cleft Lip and/or Palate and Auricular Malformations

Objective To study the relationship between cleft lip and/or palate and auricular malformations in Finnish patients with cleft. Design Retrospective analysis of patients with an external ear malformation and either a cleft lip with or without a cleft palate (CL±P) or an isolated cleft palate (CP). Setting Tertiary referral clinic. Patients Review of hospital records of 100 patients from the register of 8200 patients with cleft in the Cleft and Craniofacial Centre at the Helsinki University Central Hospital. Main Outcome Measures Proportions of variable auricular malformations among CL±P and CP patients. Results Microtia is the most common auricular malformation among patients with cleft and is almost equally prevalent with both CL±P and CP. The prevalence of microtia increases as the severity of CL±P increases. The combination of microtia and CL±P or CP is frequently found with both oculo-auriculo-vertebral spectrum and Treacher Collins syndrome. Conclusions Microtia seems to be the most common auricular malformation among patients with cleft. The prevalence of microtia seems to increase as the severity of CL±P increases, whereas in isolated CP microtia seems to occur independently.
Religion and mental health

In this chapter, the relation between religion and mental health and vice versa has been described. From primitive times different religions have different beliefs and systems of worshipping. Every religion with their belief system has implications on mental health and illness. We described how Hindu system of beliefs and rituals may have an effect in causation of various mental illnesses. It is also described how religion can help an individual to sustain one's life in various domains. The relationship between different religion and symptomatology is described. The impact and outcome of religion on mental health have been highlighted.
Fair bets and inductive probabilities

The question of what constitutes fairness in betting quotients has been studied by Ramsey, deFinetti, and Shimony. Thanks to their combined efforts we now have a satisfactory definition of fairness. On the other hand, the explication of the concept of degree of confirmation (inductive probability) has progressed rapidly in recent years, thanks primarily to Carnap. This explication has usually proceeded by laying down the axioms for frequency-probabilities, and elaborating on these. While in the case where a frequency interpretation is intended these axioms are clearly justified, in our case they have been laid down without any justification. Carnap's presentation has been criticized for just this reason. The purpose of this paper is to show that the probability axioms are necessary and sufficient conditions to assure that the degrees of confirmation form a set of fair betting quotients. In addition it will be shown that one additional, highly controversial, axiom is precisely the condition needed to assure that not only deFinetti's weaker criterion but Shimony's criterion of fairness is also satisfied.
Protective Effects of Dietary Antioxidants on Proton Total-Body Irradiation-Mediated Hematopoietic Cell and Animal Survival

Abstract Dietary antioxidants have radioprotective effects after γ-radiation exposure that limit hematopoietic cell depletion and improve animal survival. The purpose of this study was to determine whether a dietary supplement consisting of l-selenomethionine, vitamin C, vitamin E succinate, α-lipoic acid and N-acetyl cysteine could improve survival of mice after proton total-body irradiation (TBI). Antioxidants significantly increased 30-day survival of mice only when given after irradiation at a dose less than the calculated LD50/30; for these data, the dose-modifying factor (DMF) was 1.6. Pretreatment of animals with antioxidants resulted in significantly higher serum total white blood cell, polymorphonuclear cell and lymphocyte cell counts at 4 h after 1 Gy but not 7.2 Gy proton TBI. Antioxidants significantly modulated plasma levels of the hematopoietic cytokines Flt-3L and TGFβ1 and increased bone marrow cell counts and spleen mass after TBI. Maintenance of the antioxidant diet resulted in improved recovery of peripheral leukocytes and platelets after sublethal and potentially lethal TBI. Taken together, oral supplementation with antioxidants appears to be an effective approach for radioprotection of hematopoietic cells and improvement of animal survival after proton TBI.
THE EFFECT OF ACRIDINE DYES ON MATING TYPE FACTORS IN ESCHERICHIA COLI.

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Occurrence of the Campylobacter resistance gene tetO in Enterococcus and Streptococcus spp

The distribution of nucleotide sequences related to tetK, tetL, tetM, and tetO was studied by dot blot hybridization in 178 strains of Streptococcus and Enterococcus spp. that were resistant to tetracycline. The tetO gene, which is responsible for tetracycline resistance in Campylobacter spp. , was detected in six Streptococcus strains and two Enterococcus strains, in which it was borne by similar plasmids. This observation confirms our previous proposal that tetO originated in gram-positive cocci. tetM, the most prevalent resistance gene, was present alone in 109 strains and associated with tetL in 33 strains in which the two genes contributed cooperatively to high-level tetracycline resistance. tetL was present alone in five Enterococcus strains, and tetK was detected in a single Streptococcus strain. The existence of 22 strains that did not hybridize to the probes suggest that tetracycline resistance in streptococci and enterococci involves additional gene classes as well.