Miracle-dz/UniFAR-FTUs huggingface dataset:
Intraindividual strategy shifts in Raven's matrices, and their dependence on working memory capacity and need for cognition.

Strategic behavior plays a key role in fluid intelligence tasks like Raven's matrices. Some participants solve items using the strategy of mentally constructing the answer (constructive matching), which is effective but costly for complex problems; other participants rely on the less accurate strategy of discarding potential answers (response elimination). While this process is relatively well-known, past research hints that intraindividual changes in strategy use may also take place as the task becomes increasingly difficult; however, intraindividual variability in Raven's matrices is poorly understood. The present study aimed to (a) test the hypothesis that participants dynamically shift between strategies during the course of Raven's matrices, as predicted by the literature, and (b) investigate the possibility that these shifts are moderated by individual differences in both ability and motivation. Two samples of 100 participants each completed Raven's advanced progressive matrices, and measures of working memory and need for cognition. The results confirmed that participants tended to turn to the less costly response elimination strategy as the difficulty of the task increased; this variability in strategy use predicted 78% of item-to-item variance in accuracy. Working memory capacity and need for cognition predicted strategy use, and working memory capacity additionally moderated the shift toward response elimination, so that only participants with both high working memory capacity and high need for cognition continued using constructive matching in the later part of the task. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
In Reply to Gürdoğan and Altay

We would like to thank you for this letter that gives us an opportunity to further comment on the results of our study (1). In the article, we emphasized the importance of the adipokine profile, as a whole and not a single biomarker, as the main conclusion of our research. In view of the present data, the leptin to adiponectin ratio is a strong and affordable candidate, but we cannot disregard the potential of the large number of adipokines secreted by unhealthy adipocytes to be better markers. Moreover, we are aware that gender differences have been reported with respect to adipokine secretion; therefore, the correlations that we reported were checked for gender influence. The correlation was maintained, regardless of gender. However, this does not mean that the individual components, i.e., the leptin and adiponectin plasma values, did not differ between men and women in our study. In accordance to the article cited by Dr. Gürdogan and Dr. Altay, we found both leptin and adiponectin to be significantly higher in women than that in men (2). However, contrary to the previously mentioned study (1), the leptin to adiponectin ratio was similar in both the sexes (Kruskal–Wallis, ANOVA, p=0.845, H=0.038). Similarly, no significant gender differences were reported by other authors with respect to the leptin to adiponectin ratio and the incidence of the metabolic syndrome (3) in cross sectional studies. The different reference values in women and men are probably justified by the hormonal secretions and distribution of visceral versus subcutaneous fat (4,5). In prospective studies, this difference leads to gender-specific cut-offs of the leptin to adiponectin ratio for the prediction of risk (6) as well as prediction of the regression of the metabolic syndrome in high-risk individuals (7). Our study was not a longitudinal one and did not analyze such differences; however, if it would have been, the sex difference in the adipokine profile would have been a part of the analysis. There are definitely more questions to be answered about the best biomarker profile of the unhealthy adipose tissue (8), and we agree that distinguishing the gender and age categories will better stratify the risk.
Antihypertensive Treatment in Diabetic Kidney Disease: The Need for a Patient-Centered Approach

Diabetic kidney disease affects up to forty percent of patients with diabetes during their lifespan. Prevention and treatment of diabetic kidney disease is currently based on optimal glucose and blood pressure control. Renin–angiotensin aldosterone inhibitors are considered the mainstay treatment for hypertension in diabetic patients, especially in the presence of albuminuria. Whether strict blood pressure reduction entails a favorable renal outcome also in non-albuminuric patients is at present unclear. Results of several clinical trials suggest that an overly aggressive blood pressure reduction, especially in the context of profound pharmacologic inhibition of the renin–angiotensin–aldosterone system may result in a paradoxical worsening of renal function. On the basis of this evidence, it is proposed that blood pressure reduction should be tailored in each individual patient according to renal phenotype.
THE DYNAMICAL RELATIONSHIP BETWEEN THE BAR AND SPIRAL PATTERNS OF NGC 1365

Theories that attempt to explain the dynamical relationship between bar and spiral patterns in galactic disks make different predictions about the radial profile of the pattern speed. These are tested for the H-alpha bar and spiral patterns of NGC 1365. The radial profile of the pattern speed is measured by fitting mathematical models that are based on the Tremaine–Weinberg method. The results show convincing evidence for the bar rotating at a faster rate than the spiral pattern, inconsistent with a global wave mode or a manifold. There is evidence for mode coupling of the bar and spiral patterns at the overlap of corotation and inner Lindblad resonances (ILRs), but the evidence is unreliable and inconsistent. The results are the most consistent with the bar and spiral patterns being dynamically distinct features. The pattern speed of the bar begins near an ILR and ends near the corotation resonance (CR). The radial profile of the pattern speed beyond the bar most closely resembles what is expected for coupled spiral modes and tidal interactions.
First and recurrent events after percutaneous coronary intervention: implications for survival analyses

Abstract Objectives. Using composite endpoints and/or only first events in clinical research result in information loss and alternative statistical methods which incorporate recurrent event data exist. We compared information-loss under traditional analyses to alternative models. Design. We conducted a retrospective analysis of patients who underwent percutaneous coronary intervention (Jan2010-Dec2014) and constructed Cox models for a composite endpoint (readmission/death), a shared frailty model for recurrent events, and a joint frailty (JF) model to simultaneously account for recurrent and terminal events and evaluated the impact of heart failure (HF) on the outcome. Results. Among 4901 patients, 2047(41.8%) experienced a readmission or death within 1 year. Of those with recurrent events, 60% had ≥1 readmission and 6% had >4; a total of 121(2.5%) patients died during follow-up. The presence of HF conferred an adjusted Hazard ratio (HR) of 1.32 (95% CI: 1.18–1.47, p < .001) for the risk of composite endpoint (Cox model), 1.44 (95% CI: 1.36–1.52, p < .001) in the frailty model, and 1.34 (95% CI:1.22–1.46, p < .001) in the JF model. However, HF was not associated with death (HR 0.87, 95% CI: 0.52–1.48, p = .61) in the JF model. Conclusions. Using a composite endpoint and/or only the first event yields substantial loss of information, as many individuals endure >1 event. JF models reduce bias by simultaneously providing event-specific HRs for recurrent and terminal events.
Mouse Nr2f1 haploinsufficiency unveils new pathological mechanisms of a human optic atrophy syndrome

Optic nerve atrophy represents the most common form of hereditary optic neuropathies leading to vision impairment. The recently described Bosch‐Boonstra‐Schaaf optic atrophy (BBSOA) syndrome denotes an autosomal dominant genetic form of neuropathy caused by mutations or deletions in the NR2F1 gene. Herein, we describe a mouse model recapitulating key features of BBSOA patients—optic nerve atrophy, optic disc anomalies, and visual deficits—thus representing the only available mouse model for this syndrome. Notably, Nr2f1‐deficient optic nerves develop an imbalance between oligodendrocytes and astrocytes leading to postnatal hypomyelination and astrogliosis. Adult heterozygous mice display a slower optic axonal conduction velocity from the retina to high‐order visual centers together with associative visual learning deficits. Importantly, some of these clinical features, such the optic nerve hypomyelination, could be rescued by chemical drug treatment in early postnatal life. Overall, our data shed new insights into the cellular mechanisms of optic nerve atrophy in BBSOA patients and open a promising avenue for future therapeutic approaches.
Massive relic galaxies prefer dense environments

We study the preferred environments of $z \sim 0$ massive relic galaxies ($M_\star \gtrsim 10^{10}~\mathrm{M_\odot}$ galaxies with little or no growth from star formation or mergers since $z \sim 2$). Significantly, we carry out our analysis on both a large cosmological simulation and an observed galaxy catalogue. Working on the Millennium I-WMAP7 simulation we show that the fraction of today massive objects which have grown less than 10 per cent in mass since $z \sim 2$ is ~0.04 per cent for the whole massive galaxy population with $M_\star > 10^{10}~\mathrm{M_\odot}$. This fraction rises to ~0.18 per cent in galaxy clusters, confirming that clusters help massive galaxies remain unaltered. Simulations also show that massive relic galaxies tend to be closer to cluster centres than other massive galaxies. Using the New York University Value-Added Galaxy Catalogue, and defining relics as $M_\star \gtrsim 10^{10}~\mathrm{M_\odot}$ early-type galaxies with colours compatible with single-stellar population ages older than 10 Gyr, and which occupy the bottom 5-percentile in the stellar mass-size distribution, we find $1.11 \pm 0.05$ per cent of relics among massive galaxies. This fraction rises to $2.4 \pm 0.4$ per cent in high-density environments. Our findings point in the same direction as the works by Poggianti et al. and Stringer et al. Our results may reflect the fact that the cores of the clusters are created very early on, hence the centres host the first cluster members. Near the centres, high-velocity dispersions and harassment help cluster core members avoid the growth of an accreted stellar envelope via mergers, while a hot intracluster medium prevents cold gas from reaching the galaxies, inhibiting star formation.
Zombie ant death grip due to hypercontracted mandibular muscles

ABSTRACT There are numerous examples of parasites that manipulate the behavior of the hosts that they infect. One such host–pathogen relationship occurs between the ‘zombie-ant fungus’ Ophiocordyceps unilateralis sensu lato and its carpenter ant host. Infected ants climb to elevated locations and bite onto vegetation where they remain permanently affixed well after death. The mandibular muscles, but not the brain, of infected ants are extensively colonized by the fungus. We sought to investigate the mechanisms by which O. unilateralis s.l. may be able to influence mandibular muscle contraction despite widespread muscle damage. We found that infected muscles show evidence of hypercontraction. Despite the extensive colonization, both motor neurons and neuromuscular junctions appear to be maintained. Infection results in sarcolemmal damage, but this is not specific to the death grip. We found evidence of precise penetration of muscles by fungal structures and the presence of extracellular vesicle-like particles, both of which may contribute to mandibular hypercontraction. Editors' Choice: Using microscopy, we show how the zombie ant fungus (Ophiocordyceps kimflemingiae) alters the mandibular muscle of its host (Camponotus castaneus) during the death grip, a key behavior associated with transmission.
Development and evaluation of a cavitation algorithm

A numerical procedure to predict the effects of gaseous cavitation in moderately to heavily loaded bearings is developed. The method is an outgrowth of the Elrod algorithm which is simple to use and which automatically implements cavitation boundary conditions at film rupture and reformation. The current procedure makes use of type differencing in the shear induced flow formulation to automatically switch from central to upwind differences, and vice versa, at cavitation boundaries. Comparison is made with the results obtained using Elrod's algorithm for various test cases involving both slider and journal bearings. Presented at the 43rd Annual Meeting in Cleveland, Ohio May 9–12, 1988
Clinical Impact of Intracerebral Hemorrhage after Hyperacute Extracranial Stenting in Patients with Ischemic Stroke

Purpose Emergent intracranial occlusions causing acute ischemic stroke are often related to extracranial atherosclerotic stenosis. This study aimed to investigate the association between post-procedure intracerebral hemorrhage (ICH) and emergent extracranial artery stenting and assess their effects on clinical outcomes in patients with acute ischemic stroke. Materials and Methods We retrospectively analyzed patients undergoing hyperacute endovascular treatment for cervicocephalic vascular occlusion in three Korean hospitals between January 2011 and February 2016. Patients who had extracranial artery involvement and were treated from 24 hours of symptom onset to puncture were included in this study, and they were divided into the extracranial stenting (ES) and non-ES groups. Any type of petechial hemorrhages and parenchymal hematoma was defined as ICH for the current study. Results In total, 76 patients were included in this study. Among them, 56 patients underwent ES, and 20 patients did not. Baseline characteristics, risk factors, laboratory data, treatment methods, successful reperfusion rates, and baseline stenotic degrees of extracranial internal carotid artery did not differ between these two groups. However, atrial fibrillation was more frequent in patients without than with ES (P=0.002), and post-procedure ICH was more frequent in patients with than without ES (P=0.035). Logistic regression models revealed that ES was independently associated with post-procedure ICH (odds ratio [OR], 7.807; 95% confidence interval [CI], 1.213–50.248; P=0.031), and ICH was independently associated with poor clinical outcomes (OR, 0.202; 95% CI, 0.054–0.759; P=0.018); however, ES itself was not associated with clinical outcomes (OR, 0.530; 95% CI, 0.117–2.395; P=0.409). Notably, ICH and ES had interaction for predicting good outcomes (P=0.041). Conclusion Post-procedure ICH was associated with ES and poor clinical outcomes. Therefore, ES should be cautiously considered in patients with hyperacute stroke.
Effect of Systolic and Diastolic Blood Pressure on Cardiovascular Outcomes.

BACKGROUND The relationship between outpatient systolic and diastolic blood pressure and cardiovascular outcomes remains unclear and has been complicated by recently revised guidelines with two different thresholds (≥140/90 mm Hg and ≥130/80 mm Hg) for treating hypertension. METHODS Using data from 1.3 million adults in a general outpatient population, we performed a multivariable Cox survival analysis to determine the effect of the burden of systolic and diastolic hypertension on a composite outcome of myocardial infarction, ischemic stroke, or hemorrhagic stroke over a period of 8 years. The analysis controlled for demographic characteristics and coexisting conditions. RESULTS The burdens of systolic and diastolic hypertension each independently predicted adverse outcomes. In survival models, a continuous burden of systolic hypertension (≥140 mm Hg; hazard ratio per unit increase in z score, 1.18; 95% confidence interval [CI], 1.17 to 1.18) and diastolic hypertension (≥90 mm Hg; hazard ratio per unit increase in z score, 1.06; 95% CI, 1.06 to 1.07) independently predicted the composite outcome. Similar results were observed with the lower threshold of hypertension (≥130/80 mm Hg) and with systolic and diastolic blood pressures used as predictors without hypertension thresholds. A J-curve relation between diastolic blood pressure and outcomes was seen that was explained at least in part by age and other covariates and by a higher effect of systolic hypertension among persons in the lowest quartile of diastolic blood pressure. CONCLUSIONS Although systolic blood-pressure elevation had a greater effect on outcomes, both systolic and diastolic hypertension independently influenced the risk of adverse cardiovascular events, regardless of the definition of hypertension (≥140/90 mm Hg or ≥130/80 mm Hg). (Funded by the Kaiser Permanente Northern California Community Benefit Program.).
Mapping of agronomic traits, disease resistance and malting quality in a wide cross of two-row barley cultivars

Wide crosses between genetically diverged parents may reveal novel loci for crop improvement that are not apparent in crosses between elite cultivars. The landrace Chevallier was a noted malting barley first grown in 1820. To identify potentially novel alleles for agronomic traits, Chevallier was crossed with the modern malting cultivar NFC Tipple generating two genetically diverse recombinant inbred line populations. Genetic maps were produced using genotyping-by-sequencing and 384-SNP genotyping, and the populations were phenotyped for agronomic traits to allow the identification of quantitative trait loci (QTL). Within the semi-dwarf 1 (sdw1) region on chromosome 3H Chevallier conferred increased plant height and reduced tiller number, with QTL for these traits explaining 79.4% and 35.2% of the phenotypic variance observed, respectively. Chevallier was also associated with powdery mildew susceptibility, with a QTL on 1H accounting for up to 19.1% of the variance and resistance at this locus most likely resulting from an Mla variant from Tipple. Two novel QTL for physiological leaf spotting were identified on 3H and 7H, explaining up to 17.1% of the variance and with the Chevallier allele reducing symptom severity on 7H. Preliminary micromalting analysis was also undertaken to compare the malting characteristics of Chevallier and Tipple. Chevallier malt contained significantly lower levels of both α-amylase and wort β-glucan than Tipple malt, however no significant differences were observed for the remaining malting parameters measured. This suggests that the most obvious improvements in barley since the introduction of Chevallier are for agronomic traits such as height, yield and lodging resistance rather than for malting characteristics. Overall, our results demonstrate that this wide cross between Chevallier and Tipple may provide a source of novel QTL for barley breeding.
Plasmid Replicons and β-Lactamase-Encoding Genes of Multidrug-Resistant Escherichia coli Isolated from Humans and Food Animals in Lagos, Southwest Nigeria.

As resistance to the β-lactam class of antibiotics has become a worldwide problem, multidrug-resistant (MDR) human (n = 243) and food animal (n = 211) isolates from Lagos, Nigeria were further tested to characterize β-lactamase-encoding genes and plasmid replicons. Four β-lactamase-encoding genes (blaCMY, blaCTX-M, blaOXA, and blaTEM) were detected using PCR-based replicon typing, 13 and 17 different replicons were identified using a subset of MDR E. coli from humans (n = 48) and animals (n = 96), respectively. Replicon types FIB and X2 were detected in equal numbers (2/48; 4.2% each) from human isolates, while type Y (16/96; 16.7%) was the most common type from animals. Only two replicon types, FIB and Y, were detected in both groups; all other types were confined to one group or the other, but not both. Using conjugation, replicon type Y, present in three donors, transferred in all three instances, whereas FIA transferred in 75% (3/4) of the matings. This study showed that β-lactamase genes were prevalent in MDR E. coli from both humans and animals in Nigeria and also contained diverse plasmid replicons. As the replicon-associated genes were mobile, they are likely to continue disseminating among E. coli and facilitating transfer of associated β-lactamase genes in this region.
Development of a catheter-based technique for endoluminal radiofrequency sealing of pancreatic duct

Abstract Introduction: Endoluminal sealing of the pancreatic duct by glue or sutures facilitates the management of the pancreatic stump. Our objective was to develop a catheter-based alternative for endoluminal radiofrequency (RF) sealing of the pancreatic duct. Materials and methods: We devised a novel RF ablation technique based on impedance-guided catheter pullback. First, bench tests were performed on ex vivo models to tune up the technique before the in vivo study, after which endoluminal RF sealing of a ∼10 cm non-transected pancreatic duct was conducted on porcine models using a 3 Fr catheter. After 30 days, sealing effectiveness was assessed by a permeability test and a histological analysis. Results: The RF technique was feasible in all cases and delivered ∼5 W of power on an initial impedance of 308 ± 60 Ω. Electrical impedance evolution was similar in all cases and provided guidance for modulating the pullback speed to avoid tissue sticking and achieve a continuous lesion. During the follow-up the animals rate of weight gain was significantly reduced (p < 0.05). Apart from signs of exocrine atrophy, no other postoperative complications were found. At necropsy, the permeability test failed and the catheter could not be reintroduced endoluminally, confirming that sealing had been successful. The histological analysis revealed a homogeneous exocrine atrophy along the ablated segment in all the animals. Conclusions: Catheter-based RF ablation could be used effectively and safely for endoluminal sealing of the pancreatic duct. The findings suggest that a fully continuous lesion may not be required to obtain complete exocrine atrophy.
Transparent carbon nanotubes promote the outgrowth of enthorino‐dentate projections in lesioned organ slice cultures

The increasing engineering of carbon‐based nanomaterials as components of neuroregenerative interfaces is motivated by their dimensional compatibility with subcellular compartments of excitable cells, such as axons and synapses. In neuroscience applications, carbon nanotubes (CNTs) have been used to improve electronic device performance by exploiting their physical properties. Besides, when manufactured to interface neuronal networks formation in vitro, CNT carpets have shown their unique ability to potentiate synaptic networks formation and function. Due to the low optical transparency of CNTs films, further developments of these materials in neural prosthesis fabrication or in implementing interfacing devices to be paired with in vivo imaging or in vitro optogenetic approaches are currently limited. In the present work, we exploit a new method to fabricate CNTs by growing them on a fused silica surface, which results in a transparent CNT‐based substrate (tCNTs). We show that tCNTs favor dissociated primary neurons network formation and function, an effect comparable to the one observed for their dark counterparts. We further adopt tCNTs to support the growth of intact or lesioned entorhinal–hippocampal complex organotypic cultures (EHCs). Through immunocytochemistry and electrophysiological field potential recordings, we show here that tCNTs platforms are suitable substrates for the growth of EHCs and we unmask their ability to significantly increase the signal synchronization and fiber sprouting between the cortex and the hippocampus with respect to Controls. tCNTs transparency and ability to enhance recovery of lesioned brain cultures, make them optimal candidates to implement implantable devices in regenerative medicine and tissue engineering.