Miracle-dz/UniFAR-FTUs huggingface dataset:
Techniques for visualizing LSTMs applied to electrocardiograms

This paper explores four different visualization techniques for long short-term memory (LSTM) networks applied to continuous-valued time series. On the datasets analysed, we find that the best visualization technique is to learn an input deletion mask that optimally reduces the true class score. With a specific focus on single-lead electrocardiograms from the MIT-BIH arrhythmia dataset, we show that salient input features for the LSTM classifier align well with medical theory.
Antimicrobial Properties of Hydrogen Peroxide and Sodium Bicarbonate Individually and in Combination Against Selected Oral, Gram-negative, Facultative Bacteria

The topical application of hydrogen peroxide (H2O2) and sodium bicarbonate (NaHC03), individually and in combination, has been used empirically in the treatment of periodontal diseases. In this study, we examined both minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) of these disinfectants individually and in combination against selected facultative, Gram-negative oral bacteria in a microtiter dilution assay. The bacteria studied included Actinobacillus actinomycetemcomitans, Haemophilus aphrophilus, Eikenella corrodens, and Capnocytophaga gingivalis. These bacteria exhibited MBC (one hr) values ranging from 75 μmol/L to greater than 10 mmol/L and MIC from <5 to 500 μmol/L for H2O2 . The tested bacteria exhibited MIC values for NaHCO3 of from 23 to 182 mmol/L, and the MBC (one hr) exceeded 728 mmol/L for most of the strains examined. At sublethal (sub-MIC) concentrations, sodium bicarbonate antagonized the ability of H2O2 to inhibit bacterial growth in MIC assays, but sublethal concentrations of H2O 2 had no effect on the MIC values of NaHCO3. Lethal concentrations of H2O2 and NaHC03 exhibited synergistic antimicrobial activity in combination in one-hour bactericidal assays. Since the bactericidal properties of these antimicrobial agents are synergistic, we conclude that it may be rational to use them in combination to treat certain forms of periodontal disease. Also, lower and perhaps safer concentrations of H2O2 can be used in combination with NaHC03 when oxidative antimicrobial chemotherapy is indicated.
Survival strategies in social work: a study of how coping strategies affect service quality, professionalism and employee health

The restructuring of human service organisations into more lean organisations has brought increased work demands for many human service professions. Social work stands out as a particularly exposed occupational group, in which high work demands are paired with a large individual responsibility to carry out the job. The objectives of the study were to identify what kind of coping strategies social workers employ to handle the imbalance between demands and resources in work and to investigate how different strategies affect outcomes regarding health, service quality and professional development. Sixteen individual interviews and four group interviews with another 16 social workers were conducted. The analysis identified five different main types of strategies: Compensatory, Demand-reducing, Disengagement, Voice and Exit. An extensive use of compensatory strategies was connected with negative outcomes in health. Often, these compensatory strategies were replaced or combined with different means of reducing the work demands, which in turn influence performance and service quality in a negative way. The results highlight dilemmas the social workers are facing when the responsibility to deal with this imbalance is ‘decentralised’ to the individual social worker. When resources do not match the organisational goals or quality standards, the social workers are forced into strategies that either endanger their own health or threaten the quality of service.
Activity of oxyclozzanide, nitroxynil, clorsulon and albendazole against adult triclabendazole resistant Fasciola hepatica

mouths are being examined for the presenc( tion. However, where there is a high perce lesions, some consideration should be ma length, herbage contamination by poachir feeding blocks, and stress factors. With no such factors may be inducing the OMAGOD le dence for any possibility of FMD infection sho up. Such factors are speculative, but, because upon time and the inability to submit blood FMD-induced restrictions, it was not possible 1 other epidemiological investigations, or any other than histopathology.
Influence of Er,Cr: YSGG laser on bond strength of self-adhesive resin cement

The purpose of this study was to investigate the bond strength of fiber post previously laser treated root canals. Forty single-rooted bovine teeth were endodontically treated, randomly and equally divided into two main groups according to the type of pretreatment: G1: 2.5% NaOCl (control group); and G2: Er,Cr:YSGG laser. Each group was further subdivided into 2 groups based on the category of adhesive systems/ luting materials used: a: an etch-and-rinse resin cement (Single Bond/RelyX ARC; 3M ESPE), and b: a self-adhesive resin cement (Rely X Unicem; 3M ESPE). Three 1.5 mm thick slabs were obtained per root and the push-out test was performed at a crosshead speed of 0.5 mm/min until post dislodgement occurred. Data were analyzed by ANOVA and post-hoc Tukey's test at a pre-set alpha of 0.05. Analysis of variance showed no statistically significant difference (p > 0.05) among the groups G1a (25.44 ± 2.35) and G1b (23.62 ± 3.48), G2a (11.77 ± 2.67) and G2b (9.93 ± 3.37). Fractures were observed at the interface between the dentin and the resin in all groups. The Er,Cr:YSGG laser irradiation did not influence on the bond strength of the resin cements and the etch-and-rinse resin cement had better results on bond strength than self-adhesive resin cement.
Effects of Various Gases on the Survival of Dried Bacteria During Storage

Salmonella newport and Pseudomonas fluorescens were dried together in papain digest broth and sucrose-glutamate, and stored in several gases at various water activities (aw) between 0.00 and 0.40 at 25 C for various periods up to 81 weeks. Both S. newport and P. fluorescens, dried in papain digest broth and stored in air, died rapidly if the conditions were very dry (0.00 aw) or moist (0.40 aw). Storage in carbon dioxide and argon gave greater survival than storage in air but lower survival than did storage in nitrogen or in vacuo. When the organisms were dried in a sucrose-glutamate mixture the differences between the gases were very small, and variations in residual water were less important. Of the inert gases, argon gave the best survival when the organisms were dried in papain digest broth, especially at 0.00 aw; the survival in neon and krypton was lower and in xenon and helium it was much lower.
Cytolytic T lymphocytes specific for tumors and infected cells from mice with a retrovirus-induced immunodeficiency syndrome

LP-BM5 retrovirus complex-infected C57BL/6 mice develop immunodeficiency, somewhat analogous to AIDS, termed murine AIDS (MAIDS). After secondary stimulation with syngeneic B-cell lymphomas from LP-BM5-infected mice, C57BL/6 mice produced vigorous CD8+ cytotoxic T lymphocytes specific for MAIDS-associated tumors. An anti-LP-BM5 specificity was suggested because spleen and lymph node cells from LP-BM5-infected mice served as target cells in competition assays, and cells from LP-BM5, but not ecotropic, virus-infected mice functioned as secondary in vitro stimulators to generate cytotoxic T lymphocytes to MAIDS tumors.
Communications in Mathematical Physics The Fundamental Gap of Simplices

The gap function of a domain Ω ⊂ Rn is ξ(Ω) := d(λ2 − λ1), where d is the diameter ofΩ , andλ1 andλ2 are the first two positive Dirichlet eigenvalues of the Euclidean Laplacian onΩ . It was recently shown by Andrews and Clutterbuck (J Amer Math Soc 24:899–916, 2011) that for any convex Ω ⊂ Rn , ξ(Ω) ≥ 3π2, where the infimum occurs for n = 1. On the other hand, the gap function on the moduli space of n-simplices behaves differently. Our first theorem is a compactness result for the gap function on the moduli space of n-simplices. Next, specializing to n = 2, our second main result proves the recent conjecture of Antunes-Freitas (J Phys A: Math Theor 41(5):055201, 2008) for any triangle T ⊂ R2, ξ(T ) ≥ 64π 2 9 , with equality if and only if T is equilateral.
Platelet-Rich Plasma for the Aesthetic Surgeon

Abstract Platelet-rich plasma (PRP) is an autogenously harvested blood plasma containing concentrated levels of platelets and growth factors. PRP has been identified as a promising treatment for enhancing wound healing and has been used for decades in multiple medical specialties including cardiac surgery, oral surgery, ophthalmology, and orthopedic surgery. Growing evidence for multiple aesthetic surgery applications has recently been developed, particularly for hair restoration and skin rejuvenation. The goal of this article is to review the current medical literature on PRP and identify promising applications that may be integrated into a modern aesthetic surgery practice. The evidence for the use of PRP technology is rapidly expanding as a powerful therapy for select cosmetic surgery patients.
A Study on Gaze Estimation Using Head and Body Pose Information

Gaze estimation from an image is an important technique for tasks such as driver monitoring and measuring of advertising effectiveness. For this, most existing methods require a high quality image of eyes. However, It is difficult to obtain the eye images when eye occlusion occurs due to sunglasses or face rotation. Another approach approximates head directions to gaze directions. However, the gaze direction is affected not only by the head direction but also by the body direction. Thus, we are studying a method that estimates the gaze direction accurately using information on both head and body pose directions. Experimental result showed that the proposed method could estimate gaze directions more accurately than by using the information on only head directions.
Nonlinear currents in Voronoi networks.

A realistic model of transport properties of zinc oxide ceramic varistors is constructed from two-dimensional Voronoi networks, with a varying degree of disorder, and studied via computer simulations. The relationship between the current-voltage ({ital I}-{ital V}) characteristic of a single grain boundary and the {ital I}-{ital V} characteristic of the network has been determined. It is found that the breakdown voltage of the network decreases rapidly when the disorder increases. The ratio of the breakdown voltage per grain boundary, calculated from the average grain size, to the actual single barrier voltage approaches the value observed experimentally in the limit of a fully random network. Moreover, the difference between these two voltages obtained from the simulation has been expressed as a function of the standard deviation of the average grain size and compared with experimental curves, showing a very good agreement. It has been found that in the breakdown region varistor networks with nonuniform grain structure conduct the current almost exclusively through very narrow channels (paths). This current localization effect decays when the applied voltage becomes very high and the network enters the upturn region.
A contribution to the philosophy of medicine; the basic models of the doctor-patient relationship.

INTRODUCTION When a person leaves the culture in which he was born and raised and migrates to another, he usually experiences his new social setting as something strange—and in some ways threatening—and he is stimulated to master it by conscious efforts at understanding. To some extent every immigrant to the United States reacts in this manner to the American scene. Similarly, the American tourist in Europe or South America "scrutinizes" the social setting which is taken for granted by the natives. To scrutinize—and criticize—the pattern of other peoples' lives is obviously both common and easy. It also happens, however, that people exposed to cross cultural experiences turn their attention to the very customs which formed the social matrix of their lives in the past. Lastly, to study the "customs" which shape and govern one's day-to-day life is most difficult of all.1 In many ways the psychoanalyst is like a
p27 deficiency is associated with migration defects in PDGF-expressing gliomas in vivo

p27Kip1 is a cyclin dependent kinase inhibitor that functions as a tumor suppressor in a variety of different cancers. While p27 has a well established role in regulating the cell cycle, it has also been shown to regulate cellular migration by influencing the activation state of the small GTPase RhoA. We recently demonstrated that loss of p27 enhances tumor progression and leads to a dramatic decrease in survival in PDGF-induced oligodendrogliomas. Here we show that p27 deficient PDGF-expressing glial cells contained elevated levels of Rho-GTP and were less migratory than wild type cells. Migration defects in p27 deficient cells were rescued by either Rho kinase inhibition or expression of p27 or CK-, a mutant of p27 that cannot bind cyclins/cdks. The RCAS/tv-a retroviral system was used to specifically induce PDGF-expressing gliomas in mice. Many of the p27 deficient mice died earlier than wild type mice and displayed hydrocephalus which was associated with periventricular tumors that failed to invade the normal brain parenchyma. Invasion failure was reversed by co-expression of PDGF with either the GAP domain of p190RhoGAP, a negative regulator of Rho, or p27, or CK-. These results suggest that p27 mediated regulation of the Rho pathway is cell cycle independent and demonstrate for the first time a migration defect in cancer cells that is associated with p27 deficiency in vivo in a mouse tumor model.
A pharmacological tool to assess vasopressinergic co-activation of the hypothalamus–pituitary–adrenal axis more integrally in healthy volunteers

Pharmacological function tests consisting of 100 µg hCRH (corticorelin) and 10 µg dDAVP (desmopressin) mimic endogenous hypothalamus–pituitary–adrenal (HPA) axis activation. However, physiological CRH concentrations preclude informative vasopressinergic co-activation (using dDAVP) and independent quantification of both corticotrophinergic (using hCRH) and vasopressinergic (using dDAVP) activation is limited due to administration on separate occasions. This randomized, double-blind, placebo-controlled, partial five-way crossover study in healthy males and females (six : six) examined whether (1) concomitant administration of dDAVP and hCRH provides more informative vasopressinergic co-activation than dDAVP alone; and (2) whether the administration of dDAVP followed two hours later by hCRH can quantify both vasopressinergic and corticotrophinergic activation on a single test day. Combining 10 µg dDAVP with 10 µg and 30 µg hCRH caused dose-related ACTH and cortisol release which was larger than with 10 µg dDAVP alone and respectively comparable to and greater than that induced by 100 µg hCRH. Using 10 µg dDAVP alone demonstrated limited ACTH release while the effects of 100 µg hCRH two hours later were three times as large. ACTH and cortisol released by 10 µg dDAVP returned to baseline prior to 100 µg hCRH administration and dDAVP did not influence the response to subsequent hCRH administration. Dose-related vasopressinergic co-activation of the HPA axis was induced by combining 10 µg dDAVP with 10 µg and 30 µg hCRH. Combining 10 µg dDAVP with 10 µg hCRH induced the potentially most informative vasopressinergic co-activation since it is not restricted by ceiling or flooring effects. The hCRH response was not affected by prior dDAVP, allowing for a practical function test examining both HPA activation routes on the same day.
Chumbo no sangue de crianças e passivo ambiental de uma fundição de chumbo no Brasil

OBJETIVO: Determinar os niveis de chumbo no sangue de criancas que moravam proximo a uma fundicao de chumbo desativada na Cidade de Santo Amaro da Purificacao, Estado da Bahia, em setembro de 1998; e identificar fatores associados a variacao destes niveis. METODOS: Estudo de corte transversal com criancas de 1 a 4 anos de idade que residiam a menos de 1 km da fundicao. Maes ou responsaveis por 47 criancas responderam questionarios sobre transtornos do habito alimentar (comer barro, terra, reboco ou outros materiais) e outros aspectos epidemiologicos relevantes. A concentracao de chumbo no sangue foi determinada por espectrofotometria de absorcao atomica. RESULTADOS: O nivel medio de chumbo foi de 17,1 ± 7,3 mig/dL. Os niveis de chumbo no sangue foram cerca de 5 mig/dL mais elevados em criancas que tinham transtorno do habito alimentar, independentemente da idade, presenca de escoria visivel no peridomicilio, situacao de emprego do pai, historia familiar de intoxicacao pelo chumbo e desnutricao. CONCLUSOES: O passivo ambiental da fundicao de chumbo, desativada em 1993, permanece como um fator de risco relevante para elevar os niveis desse metal no sangue de criancas, particularmente aquelas que apresentam transtornos do habito alimentar.
Therapy of paraneoplastic pemphigus with Rituximab: a case report and review of literature

Paraneoplastic pemphigus (PNP) is an autoimmune blistering disease with poor prognosis when associated with malignant neoplasm. We report the case of a patient with PNP associated with a CD20+ non‐Hodgkin follicular lymphoma who was treated with Rituximab plus corticosteroids and short courses of cyclosporin. One and a half years after Rituximab therapy, oral ulcerations had cleared and oral methylprednisolone was slowly tapered down without further recurrences. In the course of the disease, the patient developed sepsis due to Listeria monocytogenes and viral infections by human herpes virus 1 and 3. At the end‐stage of the disease she developed a cutaneous infection from Mycobacterium chelonae. The patient died 2 years and 7 months after the onset of PNP. Rituximab may be useful for PNP therapy, but further studies are necessary to confirm this hypothesis.
Failure to think about failure to thrive

Perspective on the paper by Olsen et al ( see 109 ) Failure to thrive (FTT) or weight faltering has been regarded as an important problem in infancy1 associated with a range of paediatric conditions from coeliac disease2 to sudden infant death syndrome.3 Growth monitoring, perhaps the most common child surveillance activity,4 aims, among other things, to identify faltering growth,5 and generates frequent paediatric referrals.6 However, as Olsen et al 7 show, the definition of FTT is open to dispute, raising questions about the value of the weight component of growth monitoring and the continued place of weight faltering as a useful marker of disease and impaired infant development. Despite its established place in the paediatric literature (a Medline search limited to all infants and humans only with “failure to thrive” as the keyword yields >2000 references), there is no consensus on its precise definition. Undernutrition is thought to underlie FTT,8 and a recent review of articles published between January 2003 and June 2004 and recent textbooks reported that solely anthropometric parameters are now universally used in its identification.9 However, there was no agreement on which growth parameters to use and whether to use attained values or velocities.9 Thus, it seems that static definitions of low attained weight continue to be used despite longstanding recognition of their limitations.10,11 Dynamic definitions that assess weight velocity and change over time are now regarded by most researchers as preferable to attained values. However, there is limited consensus as to which dynamic definitions to use. The most frequently used in practice are those in which FTT is defined as a fall through centile lines. For example, O’Brien et al 12 defined FTT as weight falling through two major centile lines on standard weight charts …
Abundances of Sr, Y, and Zr in Metal-Poor Stars and Implications for Chemical Evolution in the Early Galaxy

We have attributed the elements from Sr through Ag in stars of low metallicities ([ Fe/H ] ≲ − 1.5) to charged-particle reactions (CPRs) in neutrino-driven winds, which are associated with neutron star formation in low-mass and normal supernovae (SNe) from progenitors of ~8-11 M☉ and ~12-25 M☉, respectively. Using this rule and attributing all Fe production to normal SNe, we previously developed a phenomenological two-component model, which predicts that [ Sr/Fe ] ⩾ − 0.32 for all metal-poor stars. This is in direct conflict with the high-resolution data now available, which show that there is a great shortfall of Sr relative to Fe in many stars with [ Fe/H ] ≲ − 3. The same conflict also exists for the CPR elements Y and Zr. We show that the data require a stellar source leaving behind black holes and that hypernovae (HNe) from progenitors of ~25-50 M☉ are the most plausible candidates. If we expand our previous model to include three components (low-mass and normal SNe and HNe), we find that essentially all of the data are very well described by the new model. The HN yield pattern for the low-A elements from Na through Zn (including Fe) is inferred from the stars deficient in Sr, Y, and Zr. We estimate that HNe contributed ~24% of the bulk solar Fe inventory while normal SNe contributed only ~9% (not the usually assumed ~33%). This implies a greatly reduced role of normal SNe in the chemical evolution of the low-A elements.
Impact of Moderating Role of e-Administration on Training, Perfromance Appraisal and Organizational Performance

In this age of information technology, organizations are revisiting their approach in great deal. E-administration is the most popular area to proceed with. Organizations in order to excel over their competitors are spending a substantial chunk of its resources on E-Administration as it is the most effective, transparent and efficient way to achieve their short term as well as long term organizational goals. E-administration being a tool of ICT plays a significant role towards effective management of HR practices resulting into optimal performance of an organization. The present research was carried out to analyze the impact of moderating role of e-administration in the relationships training and performance appraisal aligned with perceived organizational performance. The study is based on RBV and AMO theories, advocating that use of latest technology in execution of human resource (HR) functions enables an organization to achieve and sustain competitive advantage which leads to optimal firm performance. Keywords—Human resource management, HR function, eadministration, performance appraisal, training, organizational performance.
GPUSGD: A GPU‐accelerated stochastic gradient descent algorithm for matrix factorization

Matrix factorization is one of the leading techniques for many applications such as social network‐based recommendation systems. As of today, many parallel stochastic gradient descent (SGD) methods have been proposed to address the matrix factorization issue on shared‐memory (multi‐core) systems and distributed systems. However, these methods cannot be improved significantly on graphics processing unit (GPU) because the serious over‐writing problem and thread divergence may occur. The fundamental reason for such undesired results is that GPU is a parallel single instruction multiple data device, which only can greatly improve the applications with fine‐grained parallelism. In this paper, we propose an efficient GPU algorithm, named GPUSGD, to solve the matrix factorization problem based on SGD method. The major advantage of the proposed GPUSGD is that such method not only can handle the over‐writing problem but also can avoid the performance loss caused by the thread divergence. The experimental results show that GPUSGD performs much better in accelerating the matrix factorization compared with the existing state‐of‐the‐art parallel methods. To the best of our knowledge, this is the first work that develops a parallel SGD method to improve the matrix factorization on GPU. Copyright © 2015 John Wiley & Sons, Ltd.