Miracle-dz/UniFAR-FTUs huggingface dataset:
Positive Strategies to Enhance Problem-Solving Skills (STEPS): A Pilot Randomized, Controlled Trial of a Multicomponent, Technology-Enhanced, Customizable Antiretroviral Adherence Intervention for HIV-Infected Adolescents and Young Adults.

Adolescents are disproportionately impacted by HIV in the United States. Optimal effects from antiretroviral therapy (ART) can be achieved through stringent adherence to a daily medication regimen; for adolescents, this may be interrupted due to complex barriers unique to this age group. We previously conducted formative qualitative interviews with HIV-infected adolescents to identify key barriers facing adolescents regarding ART adherence and potential strategies to address these barriers. These data were used to inform an ART adherence intervention designed to overcome difficulties unique to HIV-infected adolescents (e.g., internalized stigma and HIV-related shame, disclosure to sexual partners, social life, and extracurricular activities at school, etc.). The resulting intervention-"Positive Strategies To Enhance Problem-solving Skills (Positive STEPS)"-combines five individual counseling sessions with daily text message reminders. We conducted a pilot randomized controlled trial of the intervention against a standard of care control and report on the feasibility of procedures and participant acceptability of the intervention in terms of content, structure, and format. ART adherence was measured in both arms through Medication Event Monitoring System pill caps and self-report. Feasibility and acceptability of the Positive STEPS intervention was evidenced by 90% retention for the intervention sessions; 100% completion of the four-month assessment; and positive responses on postintervention evaluation forms (all intervention participants rated Positive STEPS as "acceptable" or "very acceptable") and brief exit interviews. At the 4-month assessment visit, the change in ART adherence among the intervention group [mean change score = 13%, standard deviation (SD) = 29.5] was significantly higher compared with the standard of care group (mean change score = -26%, SD = 26.0; Cohen's d effect size = 1.43, confidence interval = 0.17-2.49, p = 0.02). Future testing of the intervention in a fully powered randomized controlled trial to determine efficacy is warranted.
Cummings Otolaryngology: Head and Neck Surgery

Will reading habit influence your life? Many say yes. Reading cummings otolaryngology head and neck surgery review is a good habit; you can develop this habit to be such interesting way. Yeah, reading habit will not only make you have any favourite activity. It will be one of guidance of your life. When reading has become a habit, you will not make it as disturbing activities or as boring activity. You can gain many benefits and importances of reading.
Aging and Recognition Memory: A Meta-Analysis

Recognizing a stimulus as previously encountered is a crucial everyday life skill and a critical task motivating theoretical development in models of human memory. Although there are clear age-related memory deficits in tasks requiring recall or memory for context, the existence and nature of age differences in recognition memory remain unclear. The nature of any such deficits is critical to understanding the effects of age on memory because recognition tasks allow fewer strategic backdoors to supporting memory than do tasks of recall. Consequently, recognition may provide the purest measure of age-related memory deficit of all standard memory tasks. We conducted a meta-analysis of 232 prior experiments on age differences in recognition memory. As an organizing framework, we used signal-detection theory (Green & Swets, 1966; Macmillan & Creelman, 2005) to characterize recognition memory in terms of both discrimination between studied items and unstudied lures (d′) and response bias or criterion (c). Relative to young adults, older adults showed reduced discrimination accuracy and a more liberal response criterion (i.e., greater tendency to term items new). Both of these effects were influenced by multiple, differing variables, with larger age deficits when studied material must be discriminated from familiar or related material, but smaller when studying semantically rich materials. These results support a view in which neither the self-initiation of mnemonic processes nor the deployment of strategic processes is the only source of age-related memory deficits, and they add to our understanding of the mechanisms underlying those changes.
Phenotypic plasticity facilitates initial colonization of a novel environment

Phenotypic plasticity can allow organisms to respond to environmental changes by producing better matching phenotypes without any genetic change. Because of this, plasticity is predicted to be a major mechanism by which a population can survive the initial stage of colonizing a novel environment. We tested this prediction by challenging wild Drosophila melanogaster with increasingly extreme larval environments and then examining expression of alcohol dehydrogenase (ADH) and its relationship to larval survival in the first generation of encountering a novel environment. We found that most families responded in the adaptive direction of increased ADH activity in higher alcohol environments and families with higher plasticity were also more likely to survive in the highest alcohol environment. Thus, plasticity of ADH activity was positively selected in the most extreme environment and was a key trait influencing fitness. Furthermore, there was significant heritability of ADH plasticity that can allow plasticity to evolve in subsequent generations after initial colonization. The adaptive value of plasticity, however, was only evident in the most extreme environment and had little impact on fitness in less extreme environments. The results provide one of the first direct tests of the adaptive role of phenotypic plasticity in colonizing a novel environment.
The neural development of prosocial behavior from childhood to adolescence

Abstract The transition from childhood to adolescence is marked by increasingly sophisticated social cognitive abilities that are paralleled by significant functional maturation of the brain. However, the role of social and neurobiological development in facilitating age differences in prosocial behavior remains unclear. Using a cross‐sectional sample of children and adolescents (n = 51; 8‐16 years), we examined the age‐related correlates of prosocial behavior. Youth made costly and non‐costly prosocial decisions to anonymous peers during a functional magnetic resonance imaging scan. Among a subsample of youth who made prosocial decisions (n = 35), we found quadratic age differences in neural activation that peaked in early adolescence relative to childhood and older adolescence. In particular, early adolescents showed heightened recruitment of the posterior superior temporal sulcus (pSTS), temporal pole and inferior frontal gyrus (IFG) when engaging in costly prosocial behavior at the expense of gaining a reward, whereas they evoked heightened pSTS and dorsolateral prefrontal cortex/IFG activation when engaging in costly vs non‐costly forms of prosocial behavior. Given that we did not find age differences in prosocial behavior, this suggests that early adolescents show unique patterns of brain activation to inform similar levels of prosocial behavior.
Cost-Effectiveness of Second-generation Direct-acting Antiviral Agents in Chronic HCV Infection: A Systematic Literature Review

Background Our objectives were to review the economic modelling methods and cost-effectiveness of second-generation direct-acting antiviral agents for the treatment of chronic HCV infection. Methods A systematic literature search was performed in February 2017 using Scopus and OVID to review relevant publications between 2011 to present. Two independent reviewers screened potential papers. Results The database search resulted in a total of 1,536 articles; after deduplication, title/abstract and full text screening, 67 studies were included for qualitative analysis. The vast majority of studies were conducted in high-income countries (n=59) and used Markov-based modelling techniques (n=60). Most of the analyses utilized long-term time horizons; 58 studies calculated lifetime costs and outcomes. The examined treatments were heterogenic among the studies; seven analyses did not directly evaluate treatments (just with screening or genotype testing). The examined treatments (n=60) were either dominant (23%), or cost-effective at base case (57%) or in given subgroups (18%). Only one (2%) study reported that the assessed treatment was not cost-effective with the given setting and price. Conclusions Despite their high initial therapeutic costs, second-generation direct-acting antiviral agents were found to be cost-effective to treat chronic HCV infection. Studies were predominantly conducted in higher income countries, although we have limited information on cost-effectiveness in low- and middle-income countries, where assessment of cost-effectiveness is even more essential due to more limited health-care resources and potentially higher public health burden due to unsafe medical interventions.
Enhancement of biological effectiveness of carbon-ion beams by applying a longitudinal magnetic field

Abstract Purpose: A magnetic field longitudinal to an ion beam will potentially affect the biological effectiveness of the radiation. The purpose of this study is to experimentally verify the significance of such effects. Methods and materials: Human cancer and normal cell lines were exposed to low (12 keV/μm) and high (50 keV/μm) linear energy transfer (LET) carbon-ion beams under the longitudinal magnetic fields of B// = 0, 0.1, 0.2, 0.3, or 0.6 T generated by a solenoid magnet. The effects of the magnetic fields on the biological effectiveness were evaluated by clonogenic cell survival. Doses that would result in a survival fraction of 10% (D10s) were determined for each cell line and magnetic field. Results: For cancer cells exposed to the low (high)-LET beams, D10 decreased from 5.2 (3.1) Gy at 0 T to 4.3 (2.4) Gy at 0.1 T, while no further decrease in D10 was observed for higher magnetic fields. For normal cells, decreases in D10 of comparable magnitudes were observed by applying the magnetic fields. Conclusions: Significant decreases in D10, i.e. significant enhancements of the biological effectiveness, were observed in both cancer and normal cells by applying longitudinal magnetic fields of B// ≥ 0.1 T. These effects were enhanced with LET. Further studies are required to figure out the mechanism underlying the observed results.
Absence of biomarker evidence for early eukaryotic life from the Mesoproterozoic Roper Group: Searching across a marine redox gradient in mid‐Proterozoic habitability

By about 2.0 billion years ago (Ga), there is evidence for a period best known for its extended, apparent geochemical stability expressed famously in the carbonate–carbon isotope data. Despite the first appearance and early innovation among eukaryotic organisms, this period is also known for a rarity of eukaryotic fossils and an absence of organic biomarker fingerprints for those organisms, suggesting low diversity and relatively small populations compared to the Neoproterozoic era. Nevertheless, the search for diagnostic biomarkers has not been performed with guidance from paleoenvironmental redox constrains from inorganic geochemistry that should reveal the facies that were most likely hospitable to these organisms. Siltstones and shales obtained from drill core of the ca. 1.3–1.4 Ga Roper Group from the McArthur Basin of northern Australia provide one of our best windows into the mid‐Proterozoic redox landscape. The group is well dated and minimally metamorphosed (of oil window maturity), and previous geochemical data suggest a relatively strong connection to the open ocean compared to other mid‐Proterozoic records. Here, we present one of the first integrated investigations of Mesoproterozoic biomarker records performed in parallel with established inorganic redox proxy indicators. Results reveal a temporally variable paleoredox structure through the Velkerri Formation as gauged from iron mineral speciation and trace‐metal geochemistry, vacillating between oxic and anoxic. Our combined lipid biomarker and inorganic geochemical records indicate at least episodic euxinic conditions sustained predominantly below the photic zone during the deposition of organic‐rich shales found in the middle Velkerri Formation. The most striking result is an absence of eukaryotic steranes (4‐desmethylsteranes) and only traces of gammacerane in some samples—despite our search across oxic, as well as anoxic, facies that should favor eukaryotic habitability and in low maturity rocks that allow the preservation of biomarker alkanes. The dearth of Mesoproterozoic eukaryotic sterane biomarkers, even within the more oxic facies, is somewhat surprising but suggests that controls such as the long‐term nutrient balance and other environmental factors may have throttled the abundances and diversity of early eukaryotic life relative to bacteria within marine microbial communities. Given that molecular clocks predict that sterol synthesis evolved early in eukaryotic history, and (bacterial) fossil steroids have been found previously in 1.64 Ga rocks, then a very low environmental abundance of eukaryotes relative to bacteria is our preferred explanation for the lack of regular steranes and only traces of gammacerane in a few samples. It is also possible that early eukaryotes adapted to Mesoproterozoic marine environments did not make abundant steroid lipids or tetrahymanol in their cell membranes.
Effects of occlusal splints on shoulder strength and activation

Abstract Introduction: The use of oral appliances to enhance sports performance has been advocated by some authors, however, studies addressing the effectiveness of these strategies are inconclusive. Methods: Here we investigate the effects of dental occlusions on shoulder strength. Fourteen healthy male subjects (age = 21.67 ± 0.86 years) without temporomandibular joint (TMJ) disorder participated in this study. Isokinetic strength was evaluated in shoulder abduction/adduction and arm external/internal rotation tests. Three randomised conditions were assessed: (1) occlusal splint (OS), which repositioned the TMJ in centric relation; (2) placebo splint (PS); and (3) no-splint (N). The strength tests were performed at a speed of 60°/sec in concentric mode. Muscle activity was measured by surface electromyography (EMG) in the main muscles engaged in the movements. Results: Significant differences in peak torque between OS and both of the other experimental conditions were found in some of the analyzed variables. Moreover, there was significantly higher muscular EMG activation in the OS condition when compared to the other conditions for some of the tested muscles. These data suggest that splints may have a positive ergogenic effect on shoulder muscular strength in healthy male subjects. Conclusion: OS may provide an advantage for healthy subjects engaged in sports whereby shoulder and arm strength are important for performance. Key messages Occlusal splints in centric relation position have an ergogenic effect, by increasing strength and muscle activation on shoulder in healthy subjects. These results could have implications for sports or other physical activities were arm and shoulder strength are important.
Experimental determination of synchronous machine parameters

Two equivalent models of synchronous machine with equal and unequal mutual reactances between the three direct-axis windings are examined. In the representation of the generator, a new method expressing the model parameters in terms of five measurable time constants is provided which does not require the usual simplifying assumptions. Furthermore, a method for computing the five time constants is given for two known tests. Three different techniques are suggested which allow the calculation of different transient phenomena. The validity of the methods developed is examined by comparing its results with those obtained from other methods. Two numerical examples are given in detail in order to demonstrate the discrepancies in values of parameters resulting from new and old methods.
Do Both Intrinsic and Identified Motivations Have Long-Term Effects?

Abstract This research examined the possible long-term effects of autonomous motivation on educational outcomes in the large scale High School Longitudinal Study 2009 (HSLS:09) data. We used a three-wave cross-lagged model to examine the longitudinal effects of intrinsic and identified motivation on 18,132 students in the mathematics domain and 16,684 students in the science domain. The results showed that intrinsic motivation was a long-term and effective enhancement agent on the subsequent academic performance, self-efficacy, identity, and course effort. In contrast, identified motivation might be sensitive to the contexts and was thus vulnerable to change in the long-term effects. Though identified motivation has positive effects on some immediate educational outcomes and is often regarded as “helpful” motivation, its positive effect is probably short-lived and might not last long in real life educational settings.
A review: Percutaneous pulmonary artery stenosis therapy: state-of-the-art and look to the future

Abstract Stenosis, or narrowing, of the branches of the pulmonary artery is a type of CHD that, if left untreated, may lead to significant complications. Ideally, interventions to treat stenosis occur before significant complications or long-term sequelae take place, often within the first 2 years of life. Treatment depends on specifics of the condition, the presence of other malformations, and age of the child. Research and recent innovation to address these shortcomings have provided physicians with safer and more effective methods of treatment. This has further continued to push the ceiling of pulmonary arterial stenosis treatment available for patients. Despite continuous advancement in angioplasty – such as conventional and cutting balloon – and stenting, each treatment method is not without its unique limitations. New technological developments such as bioresorbable stents can accommodate patient growth and pulmonary artery stenosis treatment. As more than a decade has passed since the review by Bergersen and Lock, this article aims to provide a contemporary summary and investigation into the effectiveness of various therapeutic tools currently available, such as bare metal stents and potential innovations including bioresorbable stents.
Long‐term revision rates for endoscopic sinus surgery

Reported revision rates for endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS) vary significantly. Several investigations examining revision rates for ESS have been limited by duration of follow‐up, academic centers, or small surgeon cohorts. The objective of this study was to define the long‐term revision rates for ESS and to determine those unique patient factors that increase the risk of revision ESS.
Radiolabelled Aptamers for Theranostic Treatment of Cancer

Cancer has a high incidence and mortality rate worldwide, which continues to grow as millions of people are diagnosed annually. Metastatic disease caused by cancer is largely responsible for the mortality rates, thus early detection of metastatic tumours can improve prognosis. However, a large number of patients will also present with micrometastasis tumours which are often missed, as conventional medical imaging modalities are unable to detect micrometastases due to the lack of specificity and sensitivity. Recent advances in radiochemistry and the development of nucleic acid based targeting molecules, have led to the development of novel agents for use in cancer diagnostics. Monoclonal antibodies may also be used, however, they have inherent issues, such as toxicity, cost, unspecified binding and their clinical use can be controversial. Aptamers are a class of single-stranded RNA or DNA ligands with high specificity, binding affinity and selectivity for a target, which makes them promising for molecular biomarker imaging. Aptamers are presented as being a superior choice over antibodies because of high binding affinity and pH stability, amongst other factors. A number of aptamers directed to cancer cell markers (breast, lung, colon, glioblastoma, melanoma) have been radiolabelled and characterised to date. Further work is ongoing to develop these for clinical applications.
Somatostatin Therapy in Patients with Massive Ascites After Liver Transplantation

Background Patients with massive ascites (MA) after liver transplantation (LT, defined here as daily ascitic drainage more than 1000 ml per day for more than 7 days after liver transplantation) are at increased risks of infection, hypoalbuminemia, graft loss, and even mortality. The aim of this retrospective cohort study was to investigate the effects of somatostatin on patients with MA after LT. Material/Methods Twenty-eight patients with liver cirrhosis or hepatocellular carcinoma who underwent LT complicated by MA postoperatively were included. Ten participants were receiving somatostatin therapy. The postoperative course and adverse drug effects were investigated. Daily postoperative ascitic drainage and urine output were also recorded and compared to those in the non-somatostatin group. Results The somatostatin group had significantly less ascites drainage after LT compared to the non-somatostatin group (p=0.002). Urine output was significantly increased after somatostatin administration (p<0.001). No serious adverse effects influencing graft function or fatal complications occurred after somatostatin therapy. Conclusions Somatostatin treatment is beneficial for the management of MA after liver transplantation.
Narrative Review of Hydration and Selected Health Outcomes in the General Population

Although adequate hydration is essential for health, little attention has been paid to the effects of hydration among the generally healthy population. This narrative review presents the state of the science on the role of hydration in health in the general population, specifically in skin health, neurological function (i.e., cognition, mood, and headache), gastrointestinal and renal functions, and body weight and composition. There is a growing body of evidence that supports the importance of adequate hydration in maintaining proper health, especially with regard to cognition, kidney stone risk, and weight management. However, the evidence is largely associative and lacks consistency, and the number of randomized trials is limited. Additionally, there are major gaps in knowledge related to health outcomes due to small variations in hydration status, the influence of sex and sex hormones, and age, especially in older adults and children.