Miracle-dz/UniFAR-FTUs huggingface dataset:
NUTRITIONAL RISK ACCORDING TO MINI NUTRITIONAL ASSESSMENTâ€“ SHORT FORM AMONG COMMUNITY DWELLING ELDERLY IN KUANTAN, PAHANG: A PILOT STUDY

Introduction: The risk of developing malnutrition increases with advancing age. It has the potential to place significant burdens on healthcare and other support services. However, studies with regards to malnutrition among community-dwelling elderly population in Malaysia is scarce specifically in Kuantan. The objective of this study was to determine malnutrition risk using the Mini Nutritional Assessment- Short Form (MNA-SF) among community-dwelling elderly people in Kuantan and to investigate its associated factors. Methods: A pilot study was conducted among 73 community-dwelling elderly in Kuantan, Pahang, Malaysia aged 60 years and above. Malnutrition risk of the elderly was evaluated by using Mini Nutritional Assessmentâ€“ Short Form (MNA-SF). A standardized questionnaire was used to record the factors associated with malnutrition: demographic characteristics, income level, percentage of food expenditure per month, body mass index, physical activity level and disease status. Chi Square test was performed for statistical analysis. Results: The subjects comprised of 39 (53.4%) males and 34 (46.6%) females. Mean age of the subjects was 65.4 Â± 5.4 years old. Among 73 subjects, 36.0% were well nourished and 64.0% were at malnutrition risk. Low income (p= 0.045) and physically inactive among elderly subjects (p= 0.039) appeared to be significantly associated with malnutrition risk. Other results were not statistically significant. Conclusions: The findings provide preliminary evidence that malnutrition risk was high among elderly living in Kuantan. Therefore, nutrition screening in a full-scale study is recommended for elderly in order to further identify those at risk of malnutrition in a timely manner. Hence, intervention can be implemented to improve the health status of this population.
Correlation between quality and quantity in scientific production: A case study of Iranian organizations from 1997 to 2006

In order to prevent the formation of a gap between the quality and quantity in Iranian scientific publications, this study makes an effort to analyze Iranian scientific publications indexed on the ISI Web of Science database using quantitative and qualitative scientometrics criteria over a ten year period. As a first step, all Iranian institutes were divided into three categories; universities, research institutes and other organizations. Then they were compared according to quantitative and qualitative criteria. Second, the correlation between the quality and quantity of the publications was measured. The research findings indicated that, according to qualitative criteria (citation, citation impact and percentage of cited documents) there are no meaningful differences among the three groups, while regarding quantitative criterion(number of papers), universities rank higher than the other two groups. The results also indicated that there is a positive and meaningful correlation among qualitative and quantitative criteria in the scholarly scientific publications conducted by Iranian organizations. In other words, in Iranian organizations the quality of publications increases as their quantity increases. The comparison of magnitude of correlation between these two criteria in the three categories reveals the fact that the correlation between number of papers and citations criterion in research institutes is stronger than the other two groups.
Clinical experience of narrow band imaging (NBI) usage in diagnosis of laryngeal lesions.

INTRODUCTION One of the most recent methods used in imaging of the larynx is narrow band imaging (NBI). NBI enables us to detect specific patterns of pathological angiogenesis suggestive of premalignant or neoplastic lesions. The aim of the study was to compare imaging of laryngeal lesions in white light endoscopy (WLE) and NBI in relation to histopathological examination. MATERIAL AND METHODS 333 patients with laryngeal lesions underwent endoscopic evaluation in WLE and NBI. Sensitivity, specificity, positive and negative predictive value (PPV, NPV) for WLE and NBI were calculated. The diagnostic value for WLE and NBI was evaluated for two assumptions (positive result is:1. severe dysplasia and cancer 2. only cancer) Results: Sensitivity, specificity, PPV, NPV of first assumption were respectively for white light compared to NBI: 95.4% vs 98.5%; 84.2% vs 98.5%; 79.6% vs 97.7% and 96.6% vs 99.0%. The values of second assumption were: 97.4% vs 100%; 79.3% vs 93.5%; 72.6% vs. 89.4% and 98.2% vs. 100.0%. Higher sensitivity was observed for the second assumption, while higher specifity was recorded for the first assumption. Specificity was significantly higher for NBI than for WLE (p<0.001). CONCLUSIONS NBI enables us to detect and differentiate laryngeal lesions, which are invisible in WLE. Endoscopic examination, especially in NBI-mode, is non-invasive, repeatable and remains a useful tool in the daily practice and diagnosis of patients with pathological lesions in the larynx.
Silicone gel sheeting for preventing and treating hypertrophic and keloid scars.

BACKGROUND Keloid and hypertrophic scars are common and are caused by a proliferation of dermal tissue following skin injury. They cause functional and psychological problems for patients, and their management can be difficult. The use of silicone gel sheeting to prevent and treat hypertrophic scarring is still relatively new and started in 1981 with treatment of burn scars. OBJECTIVES To determine the effectiveness of silicone gel sheeting for:(1) prevention of hypertrophic or keloid scarring in people with newly healed wounds (e.g. post surgery);(2) treatment of established scarring in people with existing keloid or hypertrophic scars. SEARCH METHODS In May 2013 we searched the Cochrane Wounds Group Specialised Register; the Cochrane Central Register of Controlled Trials (CENTRAL); Ovid MEDLINE; Ovid MEDLINE (In-Process & Other Non-Indexed Citations); Ovid EMBASE; and EBSCO CINAHL for this second update. SELECTION CRITERIA Any randomised or quasi-randomised controlled trials, or controlled clinical trials, comparing silicone gel sheeting for prevention or treatment of hypertrophic or keloid scars with any other non surgical treatment, no treatment or placebo. DATA COLLECTION AND ANALYSIS We assessed all relevant trials for methodological quality. Three review authors extracted data independently using a standardised form and cross-checked the results. We assessed all trials meeting the selection criteria for methodological quality. MAIN RESULTS We included 20 trials involving 873 people, ranging in age from 1.5 to 81 years. The trials compared adhesive silicone gel sheeting with no treatment; non silicone dressing; other silicone products; laser therapy; triamcinolone acetonide injection; topical onion extract and pressure therapy. In the prevention studies, when compared with a no treatment option, whilst silicone gel sheeting reduced the incidence of hypertrophic scarring in people prone to scarring (risk ratio (RR) 0.46, 95% confidence interval (CI) 0.21 to 0.98) these studies were highly susceptible to bias. In treatment studies, silicone gel sheeting produced a statistically significant reduction in scar thickness (mean difference (MD) -2.00, 95% CI -2.14 to -1.85) and colour amelioration (RR 3.49, 95% CI 1.97 to 6.15) but again these studies were highly susceptible to bias. AUTHORS' CONCLUSIONS There is weak evidence of a benefit of silicone gel sheeting as a prevention for abnormal scarring in high-risk individuals but the poor quality of research means a great deal of uncertainty prevails. Trials evaluating silicone gel sheeting as a treatment for hypertrophic and keloid scarring showed improvements in scar thickness and scar colour but are of poor quality and highly susceptible to bias.
Fundamental Limits of Over-the-Air Optimization: Are Analog Schemes Optimal?

We consider over-the-air convex optimization on a <inline-formula> <tex-math notation="LaTeX">$d$ </tex-math></inline-formula> dimensional space where coded gradients are sent over an additive Gaussian noise channel with variance <inline-formula> <tex-math notation="LaTeX">$\sigma ^{2}$ </tex-math></inline-formula>. The codewords satisfy an average power constraint <inline-formula> <tex-math notation="LaTeX">$P$ </tex-math></inline-formula>, resulting in the signal-to-noise ratio (SNR) of <inline-formula> <tex-math notation="LaTeX">$P/\sigma ^{2}$ </tex-math></inline-formula>. We derive bounds for the convergence rates for over-the-air optimization. Our first result is a lower bound for the convergence rate showing that any code must slowdown the convergence rate by a factor of roughly <inline-formula> <tex-math notation="LaTeX">$\sqrt {d/\log (1+ \mathtt {SNR})}$ </tex-math></inline-formula>. Next, we consider a popular class of schemes called <italic>analog coding</italic>, where a linear function of the gradient is sent. We show that a simple scaled transmission analog coding scheme results in a slowdown in convergence rate by a factor of <inline-formula> <tex-math notation="LaTeX">$\sqrt {d(1+1/ \mathtt {SNR})}$ </tex-math></inline-formula>. This matches the previous lower bound up to constant factors for low SNR, making the scaled transmission scheme optimal at low SNR. However, we show that this slowdown is necessary for any analog coding scheme. In particular, a slowdown in convergence by a factor of <inline-formula> <tex-math notation="LaTeX">$\sqrt {d}$ </tex-math></inline-formula> for analog coding remains even when SNR tends to infinity. Remarkably, we present a simple quantize-and-modulate scheme that uses <italic>Amplitude Shift Keying</italic> and almost attains the optimal convergence rate at all SNRs.
Contribution of osmotic adjustment to grain yield in Sorghum bicolor (L.) Moench under water-limited conditions. I. Water stress before anthesis.

The contribution of osmotic adjustment to grain yield in Sorghum bicolor (L.) subjected to water stress between anthesis and maturity was studied using six entries. Three of the entries (Goldrush, E57, and DK470) were selected for high osmotic adjustment and the other three (Texas 610SR, Texas 671, and SC 219-9-19-1) for low osmotic adjustment, and divided into early, intermediate and late maturity groups. Entries were either well watered, or subjected to a 50-day period of water shortage after anthesis following being well-watered prior to anthesis. Entries selected for high osmotic adjustment had mean values of osmotic adjustment at the end of the post-anthesis stress more than double those selected for low osmotic adjustment. The corresponding mean grain yield of entries with high osmotic adjustment were 24% higher than that of entries with low osmotic adjustment. The higher yield was due to both more and larger grains, and it was associated with higher harvest index and distribution index. At best, the difference in dry matter at maturity could explain only a few per cent of the difference in grain yield between entries with low and high osmotic adjustment. Water stress prior to anthesis (previous paper) reduced yield more than a post-anthesis stress of the same intensity. However, osmotic adjustment was equally effective in minimizing the reduction in grain yields in both stages. The use of osmotic adjustment as a selection trait in programs to improve the yield of grain sorghum is briefly discussed.
Pinning Synchronization of Complex Dynamical Networks With Multiweights

In this paper, we introduce two complex dynamical networks with multiweights, which have several different sorts of weights between two nodes. By means of Lyapunov functional method and pinning control technique, some sufficient conditions are derived to ensure the synchronization for proposed network models. Moreover, some adaptive strategies are given to acquire suitable coupling strengths and feedback gains. By exploiting these designed adaptive laws, several general criteria for network synchronization are established. Finally, two numerical examples are also provided to show the validity of the theoretical results.
SOBRE LA BIOLOGIA DEL CAMARON DE RIO SAMASTACUS SPINIFRONS (PHILIPPI 1882) (DECAPODA, PARASTACIDAE)

Se ha revisado la bibliografia que existe sobre Samastacus spinifrons junto a otros datos accesibles al autor, con el objetivo de actualizar el conocimiento biologico de la especie. Se analiza y se entrega informacion sobre: sistematica, distribucion geografica, habitat, caracteristicas fisicoquimicas del agua, variacion morfologica, tamano, relacion talla-peso, biologia reproductiva, estructura demografica, migraciones, habitos alimentarios, predadores, epibiontes, enfermedades, metodos de captura, comportamiento en cautiverio, calidad de la carne, comercializacion, legislacion, estado de conservacion, perspectivas de cultivo comercial, junto a otros aspectos aun no conocidos de la biologia de la especie
Lobular carcinoma of the breast with metastasis to the uterine cervix

Metastases may occur in early-stage or locally-advanced tumors in diverse locations. Nevertheless, the uterine cervix is an uncommon site for metastasis, since the majority of tumors in this organ is primary carcinomas or result from the direct extension of primary pelvic tumors. The objective of the current study was to report a clinical case considered rare in the literature, as well as discuss its implications and peculiarities. This case report describes a 57-year-old patient with lobular carcinoma metastatic to the uterine cervix, >3 years after the termination of the left breast cancer treatment. A literature analysis confirmed that most cases presented with vaginal bleeding or abdominal discomfort, but many were asymptomatic. Common characteristics between the cases were the patient's age, the time period between primary tumor diagnosis and the emergence of metastatic lesions, treatment, medication, and signs/symptoms. Although rare, metastasis should be considered in women with a history of breast cancer, particularly when the complaint is abnormal vaginal bleeding.
The extracts of Astragalus membranaceus enhance chemosensitivity and reduce tumor indoleamine 2, 3-dioxygenase expression

Astragalus membranaceus has been shown to possess anti-inflammation and antitumor properties. Several studies have indicated that extracts of Astragalus membranaceus (PG2) have growth inhibitory effects on tumor. However, the effect of PG2 on enhancing the chemotherapy, modulating tumor immune escape and their mechanism of action is unknown and need further investigation. Connexin (Cx) 43 is ubiquitous in cells and involved in facilitating the passage of chemotherapeutic drugs to bystander tumor cells. The indoleamine 2, 3-dioxygenase (IDO) depletes tryptophan, reduces the active T cell number and destroys immune surveillance. Herein, we provide evidence that the treatment of PG2 induced Cx43 expression, decreases IDO expression and enhances the distribution of chemotherapeutic drug. However, the effects of combination therapy (PG2 plus cisplatin) in animal models significantly retarded tumor growth and prolonged the survival. We believe that the information provided in this study may aid in the design of future therapy of PG2, suggest suitable combinations with chemotherapies.
Clinical activity of pembrolizumab (P) in undifferentiated pleomorphic sarcoma (UPS) and dedifferentiated/pleomorphic liposarcoma (LPS): Final results of SARC028 expansion cohorts.

11015 Background: Immune checkpoint inhibitors have demonstrated activity in multiple tumor types but their activity in soft tissue sarcomas remains limited. In the multicenter phase II study, SARC028, the anti-PD-1 antibody, P demonstrated objective responses that were largely restricted to UPS and LPS subtypes. We now report outcomes from 2 expansion cohorts of SARC 028 in advanced UPS and LPS. Methods: To further confirm the clinical activity of P in UPS and LPS, we enrolled an additional 30 pts in each of 2 expansion cohorts for a total of 40 UPS and 40 LPS pts. Primary endpoint was investigator-assessed response by RECIST v1.1. Secondary endpoints were safety, progression-free survival (PFS), 12-week PFS rate, and overall survival (OS). An ORR of 25% was considered clinically meaningful and < 10% was considered to show lack of efficacy. P was to be considered a success if 8 or more of 40 enrolled patients had a PR or better (1-sided α = 0.042, 82% power). Pts age ≥18 with advanced, refractory UPS or LPS received 200 mg of P IV every 3 weeks until progression or unacceptable toxicity. Results: Preliminary results from the first 10 pts in each of the UPS and LPS cohorts have been reported. We now present summary data after enrolling an additional 30 pts in each cohort. The ORR in the UPS cohort was 23% (9/40), with an additional 5/30 PRs observed in the expansion cohort (total 2 CRs, 7 PRs). In the LPS cohort, the ORR was 10% (4/39 evaluable pts), with an additional 2/30 PRs observed (total 4 PRs). Median PFS for the UPS group was 3 months [95% CI: 2, 5] and 2 months [95% CI: 2, 4] for the LPS group. 12-week PFS rate was 50% in UPS [95% CI: 35, 65] and 44% in LPS [95% CI: 28, 60]. The UPS group had a median OS of 12 months [95% CI: 7, 34] and 13 months [95% CI: 8, NR] for the LPS group. P was well tolerated with no unexpected toxicities. Conclusions: The UPS cohort achieved its primary endpoint, however the activity of P in UPS deserves further evaluation in a randomized study. The activity of P was not confirmed in the LPS cohort. Ongoing biomarker analyses may direct better patient selection and guide future combination strategies. Clinical trial information: NCT02301039.
Medication Use in the Community: Comparison between Urban and Rural Home Pharmacies

Objective: This study aimed to examine the contents of home pharmacies and medication use, as well as storage and disposal habits in urban and rural households in Serbia. Material and Methods: This prospective research was conducted within 70 households in Novi Sad (urban setting) and Laćarak (rural setting) from October 1, 2015 to January 15, 2016. The data were collected using a standardized questionnaire, as well as by direct examination of drugs stored in households. Results: The most common groups of drugs stored were cardiovascular drugs, drugs for the nervous system, antirheumatic products and antimicrobials. A high percentage of drugs for the alimentary tract were found stored in Laćarak, while drugs for the respiratory tract were discovered in Novi Sad. Prescription only medications (POMs) made up 69.7% of all medications in Laćarak and 60.6% in Novi Sad. POMs were purchased independently in high amounts (13.2% in Laćarak and 9.1% in Novi Sad). Presence of expired medications was higher in Laćarak (12.0%) than Novi Sad (5.8%). Over two-thirds of the households stored medications properly; however, only 10.0% of respondents reported the proper disposal of unused medications. Conclusion: The structures of home pharmacies in Novi Sad and Laćarak differ, which implies different healthcare needs. The practice of self-medicating was noted both in Novi Sad and Laćarak. While Laćarak residents rely more on the advice of friends and family, Novi Sad residents buy medicine mostly without any consultation. Medications in both environments are stored properly in the majority of households, but mostly disposed of improperly together with household waste.
Aerobic capacity predicts skeletal but not cardiac muscle damage after a full distance Ironman triathlon - the Iron(wo)man-study

Purpose: This study examines the association between aerobic capacity and biomarkers of skeletal- and cardiac muscle damage among amateur triathletes after a full distance Ironman Methods: Men and women (N=55) were recruited from local sport clubs. One month before an Ironman triathlon, they conducted a 20m shuttle run test to determine aerobic capacity. Blood samples were taken immediately after finishing the triathlon, and analyzed for biomarkers of cardiac- and skeletal muscle damage. Regression models examining the association between aerobic capacity expressed in both relative terms (mLO2*kg-1*min-1) and absolute terms (LO2*min-1) controlled for weight and were fitted. Result: A total of 39 subjects (26% females) had complete data and were included in the analysis. No association between aerobic capacity and cardiac muscle damage but a significant negative association between aerobic capacity and skeletal muscle damage was observed. This association was independent of how aerobic capacity was expressed, although the model with aerobic capacity expressed in absolute terms and controlled for weight resulted in slightly higher r2 values, than when aerobic capacity was expressed in relative terms. Conclusion: A negative association between aerobic capacity and skeletal muscle damage was seen but despite the well-known cardio-protective health effect of high aerobic fitness no such association could be observed in this study.
Peroxidase activities in bull spermatozoa

The present study was carried out to determine the localization of peroxidase activity in bull spermatozoa. 3,3′-Diaminobenzidine (DAB) was used as a substrate for revealing peroxidase activity, and light and electron microscopic analysis of the results obtained was performed. Peroxidase activity was detected in the mitochondria of the middle piece and the outer acrosomal membrane. Catalase was excluded as an enzyme, catalyzing the detected peroxidase activity. Concerning the biochemical properties of bull sperm peroxidases, peroxidase activity was found to be manifested in a large pH range, 4–10.5. Bull sperm peroxidase activity appeared to be temperature sensitive and azide sensitive and could be readily inhibited by phenylhydrazine. Electrophoretic analysis of the proteins from bull sperm extracts separated in a Davis-Ornstein system of 7% polyacrylamide gel, followed by the determination of peroxidase activity on the polyacrylamide gels, revealed that all 14 sperm protein fractions available on the gel possessed peroxidase when benzidine was used as a substrate. The possible reasons for the electrophoretic heterogeneity of bull sperm peroxidases are discussed. © 1994 Wiley-Liss, Inc.
Faktor-Faktor Yang Mempengaruhi Kepatuhan Mengkonsumsi Tablet Fe Pada Ibu Hamil

Kepatuhan mengkonsumsi tablet zat besi diukur dari ketepatan jumlah tablet zat besi yang dikonsumsi, ketepatan cara mengkonsumsi tablet zat besi, frekuensi konsumsi tablet zat besi perhari. Tujuan penelitian ini untuk mengetahui faktor pengetahuan, sikap, dukungan keluarga dan dukungan tenaga kesehatan terhadap kepatuhan mengkonsumsi tablet zat besi (Fe) pada ibu hamil di wilayah kerja Puskesmas Simeulue Timur Tahun 2018. Desain penelitian dilakukan secara survei analitik kuantitatif dengan pendekatan cross sectional. Populasi dalam penelitian adalah semua ibu hamil trimester II dan III yang mendapatkan tablet Fe sebanyak 255 orang dan Sampel yang digunakan sebanyak 72 orang yang mendapatkan tablet Fe dengan menggunakan sampel acak sistematis dan teknik sampel acak sederhana. Analisis yang digunakan adalah analisis univariat, bivariat dengan uji chi-square, analisis multivariat dengan uji regresi berganda binary. Berdasarkan analisis bivariat dengan uji chi-square, Ada pengaruh faktor pengetahuan, sikap, dukungan keluarga dan tenaga kesehatan terhadap kepatuhan mengkonsumsi tablet Fe pada ibu hamil α = 0.05 diperoleh hasil yaitu nilai p pengetahuan = 0.036 nilai p sikap = 0.003, nilai p dukungan keluarga = 0.013, dan nilai p dukungan tenaga kesehatan = 0.012. Berdasarkan analisis multivariat diketahui variabel sikap paling dominan memengaruhi kepatuhan mengkonsumsi tablet Fe pada ibu hamil dengan nilai p = 0.001 dan Exp (B) = 10.579. Oleh karena itu, ibu hamil trimester II dan trimester III perlu untuk meningkatkan pengetahuan tentang pentingnya mengkonsumsi tablet Fe dan diharapkan peran aktif keluarga serta tenaga kesehatan untuk tindakan pencegahan terjadinya anemia pada ibu hamil.