Miracle-dz/UniFAR-FTUs huggingface dataset:
Energy Expenditure and Intensity of Group-Based High-Intensity Functional Training: A Brief Report.

Background: High-intensity functional training (HIFT) may offer an attractive, time-efficient alternative to traditional aerobic exercise. However, limited information is available in the literature regarding HIFT meeting exercise guidelines for energy expenditure (improve health outcomes: ≥1000 kcal/wk; weight management: ≥2000 kcal/wk) and level of intensity (moderate: 3-6 metabolic equivalents [METs], vigorous: ≥6 METs) elicited by this approach. Thus, the primary aim was to objectively measure energy expenditure and intensity of HIFT sessions. Methods: Energy expenditure was assessed in 20 adults (18-50 y, 50% females). The HIFT session format included the following segments: warm-up (∼5 min), exercise (∼35 min), and cooldown (∼5 min). Participant oxygen consumption (COSMED, L/min and mL/kg/min), heart rate (Polar RS400), and physical activity (ActiGraph GT3X+) were collected in 15-second intervals. Average kcal per minute, METs, total kcal per session, and percent maximum heart rate (HRmax) were calculated. Results: METs ranged from 5.5 to 11.6 for the complete session (including warm-up and cooldown). Participant's HRmax was ∼80% (range: 69%-100%). Average energy expenditure was ∼485 kcal per session (∼1400 kcal/wk). The vigorous-intensity exercise portion (∼35 min) contributed to 80% of total energy expenditure. Conclusions: HIFT has the potential to meet the recommendations for exercise to improve health outcomes.
Biomechanics of the Human Temporomandibular Joint during Chewing

Experimental data on the loading of the human temporomandibular joint during chewing are scarce. Coincidence of the opening and closing chewing strokes of the condyles probably indicates compression in the joint during chewing. Using this indication, we studied the loading of the joint during chewing and chopping of a latex-packed food bolus on the left or right side of the mouth. Mandibular movements of ten healthy subjects were recorded. Distances traveled by the condylar kinematic centers were normalized with respect to the distances traveled during maximum opening. We judged coincidence of the opening and closing condylar movement traces without knowing their origin. When subjects chewed, the ipsilateral condyles traveled shorter distances than did the contralateral condyles. During chewing and chopping, all contralateral condyles showed a coincident movement pattern, while a significantly smaller number of ipsilateral condyles did. These results suggest that the ipsilateral joints were less heavily loaded during chewing and chopping than were the contralateral joints.
Prevalence of depression in survivors of acute myocardial infarction

OBJECTIVES: To assess the prevalence and persistence of depression in patients with acute myocardial infarction (AMI) and the relationship between assessment modality and prevalence.DATA SOURCES: MEDLINE®, Cochrane, CINAHL®, PsycINFO®, and EMBASE®. REVIEW METHODS: A comprehensive search was conducted in March 2004 to identify original research studies published since 1980 that used a standardized interview or validated questionnaire to assess depression. The search was augmented by hand searching of selected journals from October 2003 through April 2004 and references of identified articles and reviews. Studies were excluded if only an abstract was provided, if not in English, or if depression was not measured by a validated method.RESULTS: Major depression was identified in 19.8% (95% confidence interval [CI] 19.1% to 20.6%) of patients using structured interviews (N=10,785, 8 studies). The prevalence of significant depressive symptoms based on a Beck Depression Inventory score ≥10 was 31.1% (CI 29.2% to 33.0%; N=2,273, 6 studies), using a Hospital Anxiety and Depression Scale (HADS) score ≥8%, 15.5% (CI 13.2% to 18.0%; N=863, 4 studies), and with a HADS score ≥11%, 7.3% (CI 5.5% to 9.3%; N=830, 4 studies). Although a significant proportion of patients continued to be depressed in the year after discharge, the limited number of studies and variable follow-up times precluded specification of prevalence rates at given time points.CONCLUSIONS: Depression is common and persistent in AMI survivors. Prevalence varies depending on assessment method, likely reflecting treatment of somatic symptoms.
Hints of the Existence of C-rich Massive Evolved Stars

We aim to study the properties of a particular type of evolved stars, C-rich evolved stars with high expansion velocities. For this purpose we have focused on the two best studied objects within this group, IRC+10401 and AFGL 2233. We focused on determining their luminosity by studying their spectral energy distribution. Also, we have obtained single-dish line profiles and interferometric maps of the CO J = 1–0 and J = 2–1 emission lines for both objects. We have modeled this emission using a LVG radiative transfer code to determine the kinetic temperature and density profiles of the gas ejected by these stars. We have found that the luminosities obtained for these objects (log(L/L⊙) = 4.1 and 5.4) locate them in the domain of the massive asymptotic giant branch stars (AGBs) and the red supergiant stars (RSGs). In addition, the mass-loss rates obtained (1.5 × 10−5–6 ×10−3 M⊙ yr−1) suggest that while IRC+10401 might be an AGB star, AFGL 2233 could be an RSG star. All these results, together with those from previous works, suggest that both objects are massive objects, IRC+10401 a massive evolved star with Minit ∼ 5–9 M⊙, which could correspond to an AGB or an RSG and AFGL 2233 an RSG with Minit ∼ 20 M⊙, which would confirm the existence of massive C-rich evolved stars. Two scenarios are proposed to form these types of objects. The first one is capable of producing high-mass AGB stars up to ∼8 M⊙ and the second one is capable of forming C-rich RSGs like AFGL 2233.
Titan Cells Confer Protection from Phagocytosis in Cryptococcus neoformans Infections

ABSTRACT The human fungal pathogen Cryptococcus neoformans produces an enlarged “titan” cell morphology when exposed to the host pulmonary environment. Titan cells exhibit traits that promote survival in the host. Previous studies showed that titan cells are not phagocytosed and that increased titan cell production in the lungs results in reduced phagocytosis of cryptococcal cells by host immune cells. Here, the effect of titan cell production on host-pathogen interactions during early stages of pulmonary cryptococcosis was explored. The relationship between titan cell production and phagocytosis was found to be nonlinear; moderate increases in titan cell production resulted in profound decreases in phagocytosis, with significant differences occurring within the first 24 h of the infection. Not only were titan cells themselves protected from phagocytosis, but titan cell formation also conferred protection from phagocytosis to normal-size cryptococcal cells. Large particles introduced into the lungs were not phagocytosed, suggesting the large size of titan cells protects against phagocytosis. The presence of large particles was unable to protect smaller particles from phagocytosis, revealing that titan cell size alone is not sufficient to provide the observed cross-protection of normal-size cryptococcal cells. These data suggest that titan cells play a critical role in establishment of the pulmonary infection by promoting the survival of the entire population of cryptococcal cells.
A Multi-Task Learning Framework for Extracting Drugs and Their Interactions from Drug Labels

Preventable adverse drug reactions as a result of medical errors present a growing concern in modern medicine. As drug-drug interactions (DDIs) may cause adverse reactions, being able to extracting DDIs from drug labels into machine-readable form is an important effort in effectively deploying drug safety information. The DDI track of TAC 2018 introduces two large hand-annotated test sets for the task of extracting DDIs from structured product labels with linkage to standard terminologies. Herein, we describe our approach to tackling tasks one and two of the DDI track, which corresponds to named entity recognition (NER) and sentence-level relation extraction respectively. Namely, our approach resembles a multi-task learning framework designed to jointly model various sub-tasks including NER and interaction type and outcome prediction. On NER, our system ranked second (among eight teams) at 33.00% and 38.25% F1 on Test Sets 1 and 2 respectively. On relation extraction, our system ranked second (among four teams) at 21.59% and 23.55% on Test Sets 1 and 2 respectively.
Value of Magnetic Resonance Imaging and Discography in Determining the Level of Cervical Discectomy and Fusion

Study Design. The correlation between magnetic resonance imaging and discography of the cervical spine in degenerative disc disease was studied. In addition, the results of cervical discectomy and fusion were evaluated. Objectives. To compare the value of cervical magnetic resonance imaging versus discography in selecting the level for discectomy and fusion and to evaluate the surgical outcome. Summary of Background Data. The value of magnetic resonance imaging and discography in patients with cervical discogenic pain is less clear. Also, the status of a hypointense signal (dark) cervical disc and/or a small herniated disc on magnetic resonance imaging has not been determined. Methods. The magnetic resonance imaging studies and discography followed by computed tomography in 55 patients with cervical discogenic pain were evaluated. Surgical planning was based on the complete information of clinical symptoms, magnetic resonance imaging, and discography as well as computed tomography discography. Anterior cervical discectomy and keystone fusion was performed. Postoperative pain relief was assessed by the patients, and the follow-up radiographs were viewed by an independent reviewer. The overall surgical outcome was evaluated using Odom’s criteria. Results. There were 161 disc levels that successfully underwent cervical discography with 79 positive levels. A positive discography result was found in 63% of dark (hypointense signal) discs and 45% of speckled discs. Fifty-nine percent of small herniated discs and 59% of torn discs had a positive discography, respectively. There were 100 abnormal cervical discs on magnetic resonance imaging. Magnetic resonance imaging had a false-positive rate of 51% and a false-negative rate of 27%. Successful cervical fusion was achieved in 95% of patients, and the overall satisfactory result was 76%. Conclusions. Magnetic resonance imaging can identify most of the painful discs but still has relatively high false-negative and false-positive rates. There is a high chance that hypointense signal and small herniated discs are the pain generators, but they are not always symptomatic. Discography can save the levels from being unnecessarily fused. The combination of clinical symptoms, magnetic resonance imaging, and discography provides the most information for decision making and can improve the management of cervical discogenic pain.
A fully monolithic integrated anisotropic magnetoresistance based angle sensor for automotive

This paper presents an automotive qualified, fully integrated AMR based sensor to enable contactless angle/position detection by means of rotating magnetic fields. The sensor provides amplified, as well as amplitude and offset compensated sinusoidal and co-sinusoidal components of the angle as differential analog voltages. The sensor allows achieving an angle error of 0.1° at room temperature as well as an overall angle error over temperature of less than 0.9° - representing a step ahead in performance of AMR angle sensors. The architecture of the sensor IC and its measurements are shown.
Higher Sun Exposure is Associated With Lower Risk of Pediatric Inflammatory Bowel Disease: A Matched Case-control Study

ABSTRACT Objectives: The incidence of pediatric inflammatory bowel disease (IBD) is increasing worldwide. Ecological studies show higher incidence in regions at higher latitude or lower ambient ultraviolet radiation; individual-level associations with sun exposure have not been assessed. Methods: We recruited children (0–17 years) with IBD from 2 large hospitals in Melbourne, Australia. Control participants were recruited from the day surgery unit of one of the same hospitals. Questionnaires provided data on demographics, past sun exposure, the likelihood of sunburn (skin sensitivity) or tanning following sun exposure, use of sun protection, physical activity, and parental smoking and education. Grandparent ancestry was used to determine participant ethnicity. Cases and controls were matched on age and sex. We used conditional logistic regression to test the association between being an IBD case and past sun exposure at different ages, adjusted for a range of other factors. Results: After matching, n = 99 cases and n = 396 controls were included in the analysis. In multivariable analysis, for each 10 min increment in leisure-time sun exposure in summer or winter there was a linear 6% reduction in the odds of having IBD (P = 0.002). Results were similar in sensitivity analyses including only the most recently diagnosed cases, only Caucasian cases and controls, only those with symptom onset within the year before study entry, or additionally adjusted for age or physical activity. Conclusions: Higher sun exposure in the previous summer or winter was associated with a reduced risk of having IBD. There are plausible pathways that could mediate this effect.
Oxygen Isotope Labeling Experiments Reveal Different Reaction Sites for the Oxygen Evolution Reaction on Nickel and Nickel Iron Oxides

Abstract Nickel iron oxide is considered a benchmark nonprecious catalyst for the oxygen evolution reaction (OER). However, the nature of the active site in nickel iron oxide is heavily debated. Here we report direct spectroscopic evidence for the different active sites in Fe‐free and Fe‐containing Ni oxides. Ultrathin layered double hydroxides (LDHs) were used as defined samples of metal oxide catalysts, and 18O‐labeling experiments in combination with in situ Raman spectroscopy were employed to probe the role of lattice oxygen as well as an active oxygen species, NiOO−, in the catalysts. Our data show that lattice oxygen is involved in the OER for Ni and NiCo LDHs, but not for NiFe and NiCoFe LDHs. Moreover, NiOO− is a precursor to oxygen for Ni and NiCo LDHs, but not for NiFe and NiCoFe LDHs. These data indicate that bulk Ni sites in Ni and NiCo oxides are active and evolve oxygen via a NiOO− precursor. Fe incorporation not only dramatically increases the activity, but also changes the nature of the active sites.
Inhibition of Chronic Rejection and Development of Tolerogenic T Cells after ICOS-ICOSL and CD40-CD40L Co-stimulation Blockade

Background. Blockade of the CD40-CD40L pathway results in long-term allograft survival but does not prevent chronic rejection. ICOS-ICOSL are members of the CD28-B7 family that play an important role in T-cell activation. Methods. The authors analyzed the effect of single or combined treatment with an anti-ICOS monoclonal antibody and the fusion molecule CD40 immunoglobulin (Ig) on acute and chronic rejection of heart allografts in rats. Results. Treatment with anti-ICOS resulted in a modest but significant prolongation of allograft survival. Treatment with CD40Ig resulted in long-term graft survival but the cardiac grafts developed chronic rejection lesions. Combined CD40Ig+anti-ICOS treatment led to indefinite graft survival in all recipients and a significant decrease of chronic rejection lesions compared with CD40Ig alone. Importantly, four of the seven CD40Ig+anti-ICOS–treated recipients showed a complete absence of chronic rejection lesions, whereas all of the CD40Ig-treated recipients showed chronic rejection. The CD40Ig+anti-ICOS group also showed significant decreased graft infiltration, decreased antidonor cytotoxic T-lymphocyte activity, and decreased alloantibodies compared with the CD40Ig-treated group. Adoptive transfer of splenocytes indefinitely prolonged allograft survival, whereas those depleted of T cells did not, suggesting the development of T-regulatory mechanisms. Conclusions. These data indicate that the chronic rejection mechanisms that are CD40-CD40L independent are ICOS-ICOSL dependent. These results were obtained with conservation of cognate immune responses and development of tolerogenic T cells.
Antibiotic Prophylaxis for Open Chest Management After Pediatric Cardiac Surgery.

OBJECTIVES Although open chest management optimizes hemodynamics after cardiac surgery, it increases postoperative infections and leads to increased mortality. Despite the importance of antibiotic prophylaxis during open chest management, no specific recommendations exist. We aimed to compare the occurrence rates of bloodstream infection and surgical site infection between the different prophylactic antibiotic regimens for open chest management after pediatric cardiac surgery. DESIGN Retrospective, single-center, observational study. SETTING PICU at a tertiary children's hospital. PATIENTS Consecutive patients less than or equal to 18 years old with open chest management after cardiac surgery followed by delayed sternal closure, between January 2012 and June 2018. INTERVENTIONS None. MEASUREMENTS AND MAIN RESULTS We compared the composite occurrence rate of postoperative bloodstream infection and surgical site infection within 30 days after cardiac surgery between three prophylactic antibiotic regimens: 1) cefazolin, 2) cefazolin + vancomycin, and 3) vancomycin + meropenem. In 63 pediatric cardiac surgeries with open chest management, 17 bloodstream infections, and 12 surgical site infections were identified postoperatively. The composite occurrence rates of bloodstream infection and surgical site infection were 10 of 15 (67%), 10 of 19 (53%), and nine of 29 (31%) in the cefazolin, cefazolin + vancomycin, and vancomycin + meropenem regimens, respectively (p = 0.07). After adjusting for age, open chest management duration, extracorporeal membrane oxygenation use, and nasal methicillin-resistant Staphylococcus aureus colonization in multivariable analysis, there was no significant difference between the cefazolin and the cefazolin + vancomycin regimens (p = 0.19), while the vancomycin + meropenem regimen had a lower occurrence rate of bloodstream infection and surgical site infection than the cefazolin regimen (odds ratio, 0.0885; 95% CI, 0.0176-0.446; p = 0.003). CONCLUSIONS In this study, a lower occurrence rate of postoperative bloodstream infection and surgical site infection was observed among patients with broad-spectrum antibiotic regimen after pediatric cardiac surgery with open chest management. Further studies, ideally randomized controlled studies investigating the efficacy of broad-spectrum antibiotics and their complications, are warranted before routine implementation of broad-spectrum prophylactic antibiotic regimen.
A Novel Algorithm for Reversible Circuit Optimization

Reversible circuit synthesis is an important field in quantum computing, low-power design, and reversible circuit. The problem of reversible circuit synthesis is complicated and hard to solve because the input of the reversible circuit will experience a huge increase when extended to multi-bit. In this paper, a novel algorithm of reversible circuit synthesis is proposed. With the satisfied priority of positions, we can efficiently select the position which should be satisfied, and each selected gate is generated to benefit the overall situation. Therefore, the proposed algorithm is able to optimize the reversible circuit with fewer gates and can be implemented in regard to multibit reversible circuit synthesis. In addition, the gate set we used contains only Toffoli, spanning all wires. This Toffoli gate is liable to be transformed into another gate set and is helpful for algorithm design. The experiment shows that the proposed algorithm, with efficient and optimal results, is superior to others.
Digit ratios and motor and health-related fitness in pre-adolescent females

Abstract Background: Assessing different aspects of physical fitness in children whose abilities are undeveloped and their associations with second-to-fourth digit ratio (2D:4D) may better determine the potential athleticism of an individual. Aim: The purpose of the study was to examine relationships between the digit ratios and selected motor and health-related fitness parameters in a large sample of pre-adolescent females. Subjects and methods: Participants included 8–12 year old Iranian and Afghan girls. The length of the left and right second and fourth digits was measured by scanning and computer-assisted image analysis. Motor- and health-related fitness tests were evaluated. Results: No significant correlations were noted between right 2D:4D ratio and physical fitness components. Left 2D:4D and physical fitness components were not correlated, with the exception of handgrip strength (r = –0.193). However, right and left second digit lengths were negatively correlated with predicted VO2max (p ≤ 0.01). In addition, right–left 2D:4D was significantly negatively correlated with flexibility, and significantly positively correlated with height and body fat percentage. Conclusion: In contrast to previous investigations, it seems that left 2D:4D is a predictor of strength, but not aerobic exercise. It is suggested there may be a potential relationship between prenatal androgen exposure and high flexibility, low body fat percentage and the generation of muscular strength in pre-adolescent females.
Dissociative subtype of posttraumatic stress disorder or PTSD with comorbid dissociative disorders: Comparative evaluation of clinical profiles.

INTRODUCTION The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (American Psychiatric Association, 2013) introduced a dissociative subtype for patients with posttraumatic stress disorder (PTSD) and depersonalization and/or derealization symptoms. Despite high comorbidity rates between PTSD and dissociative disorders (DDs), research has not paid attention to the differentiation or overlap between the dissociative subtype of PTSD and DDs. This raises a question: To what extent do patients with dissociative PTSD differ from patients with PTSD and comorbid DDs? METHOD We compared three groups of complex patients with trauma-related disorders and/or personality disorders (n = 150): a dissociative PTSD, a nondissociative PTSD, and a non-PTSD group of patients with mainly personality disorders. We used structured clinical interviews and self-administered questionnaires on dissociative symptoms and disorders, personality disorders, trauma histories, depression, anxiety, and general psychopathology. The Dissociative Experiences Scale (DES; ≥20) and the depersonalization/derealization subscale of the DES were used for differentiating dissociative PTSD from nondissociative PTSD. RESULTS Of all patients, 33% met criteria for dissociative PTSD. More than half of the dissociative PTSD patients (54%) met criteria for one or more DDs; using the depersonalization/derealization subscale of the DES, even 66% had a comorbid DD. But also of the non-PTSD patients, 24% had a mean DES score of ≥20. There were no symptomatic differences (e.g., depression and anxiety) between dissociative PTSD with and without comorbid DDs. CONCLUSION Overlap between dissociative PTSD and DD is large and we recommend replication of previous studies, using structured clinical assessment of DDs. (PsycINFO Database Record (c) 2019 APA, all rights reserved).