Miracle-dz/UniFAR-FTUs huggingface dataset:
Adrenomedullin in the adrenal

Adrenomedullin (AM) was originally characterized in extracts of an adrenal medullary tumor. Since this original finding the peptide and its mRNA have also been found in the adrenal cortex, specifically, in the cells of the aldosterone‐secreting zona glomerulosa. It is clear that the synthesis of AM is actively regulated in both cortex and medulla. Much research effort has been focused on identifying a role for AM in the adrenal gland. To date, no consistent effect on medullary catecholamine biosynthesis has been demonstrated. In the cortex the actions of AM are controversial and appear to depend on both the tissue preparation used and on the specific receptor population expressed in the individual gland. The results of further studies on the long‐term actions of AM on adrenal growth and differentiation are awaited with interest. Microsc. Res. Tech. 57:91–97, 2002. © 2002 Wiley‐Liss, Inc.
The electrical basis of excitation and inhibition in the rat anoccygeus muscle.

1. The transmembrane potential of smooth muscle cells of the rat anococcygeus muscle was studied with micro‐electrodes. The muscle had a mean resting membrane potential of ‐‐61‐5 mV and normally lacked spontaneous mechanical and electrical activity. 2. Stimulation of intramural nerves with single pulses produced a small depolarization and contraction. At frequencies greater than 0.5 Hz a second component occurred which had a maximum value of 35‐‐51 mV with short trains at 30 Hz. Spike potentials were rarely seen. Depolarization was accompanied by a decrease in membrane resistance. 3. Noradrenaline (3 times 10‐minus 5 M) and guanethidine (3 times 10‐minus 5 M) both depolarized the membrane and produced contraction. Initially, oscillations in the membrane potential were oftern seen. 4. Intramural nerve stimulation in the presence of guanethidine damped the oscillations and produced relaxation. This was accompanied by neither hyperpolarization nor a change in membrane resistance. 5. TEA (1 mM) depolarized the membrane (−‐47‐6 mV) and initiated spontaneous activity. Field stimulation evoked spikes with overshoot.
An adaptive Reichardt detector model of motion adaptation in insects and mammals

Abstract There are marked similarities in the adaptation to motion observed in wide-field directional neurons found in the mammalian nucleus of the optic tract and cells in the insect lobula plate. However, while the form and time scale of adaptation is comparable in the two systems, there is a difference in the directional properties of the effect. A model based on the Reichardt detector is proposed to describe adaptation in mammals and insects, with only minor modifications required to account for the differences in directionality. Temporal-frequency response functions of the neurons and the model are shifted laterally and compressed by motion adaptation. The lateral shift enhances dynamic range and differential motion sensitivity. The compression is not caused by fatigue, but is an intrinsic property of the adaptive process resulting from interdependence of temporal-frequency tuning and gain in the temporal filters of the motion detectors.
Ochre use in the Middle Stone Age at Sibudu, South Africa: grinding, rubbing, scoring and engraving

Many Middle Stone Age (MSA) sites have evidence of the regular collection and use of ochre. Sibudu (KwaZulu- Natal, South Africa) has a large MSA ochre assemblage of over 9000 pieces from layers dating between ~77 ka and ~38 ka. There are 682 pieces with signs of use. All usetraces were examined and activity categories were defined based on published ochre experiments. The most frequent markings on ochre pieces are grinding striations that are smoothed by subsequent rubbing. Grinding and rubbing also occur independently on many pieces. Scored pieces are rare, but are more common in the pre-Still Bay (~77 ka) industry than elsewhere in the sequence. Some scored pieces may represent deliberate engravings. Markings acquired during powder-production are most numerous in the assemblage. Powder was mostly produced from bright-red pieces, but scoring was mainly performed on brown-red pieces. Pieces with mica inclusions are not common, but were favoured for powder production. Ochre powder was used as an aggregate in hafting adhesives, but other possible applications are as paint or as a substance to aid hide tanning.
Production , Manufacturing and Logistics A bi-objective home care scheduling problem : Analyzing the trade-off between costs and client inconvenience

Organizations providing home care services are inclined to optimize their activities in order to meet the constantly increasing demand for home care. In this context, home care providers are confronted with multiple, often conflicting, objectives such as minimizing their operating costs while maximizing the service level offered to their clients by taking into account their preferences. This paper is the first to shed some light on the trade-off relationship between these two objectives by modeling the home care routing and scheduling problem as a bi-objective problem. The proposed model accounts for qualifications, working regulations and overtime costs of the nurses, travel costs depending on the mode of transportation, hard time windows, and client preferences on visit times and nurses. A distinguishing characteristic of the problem is that the scheduling problem for a single route is a bi-objective problem in itself, thereby complicating the problem considerably. A metaheuristic algorithm, embedding a large neighborhood search heuristic in a multi-directional local search framework, is proposed to solve the problem. Computational experiments on a set of benchmark instances based on real-life data are presented. A comparison with exact solutions on small instances shows that the algorithm performs well. An analysis of the results reveals that service providers face a considerable trade-off between costs and client convenience. However, starting from a minimum cost solution, the average service level offered to the clients may already be improved drastically with limited additional costs. © 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
The Decline and Rise of Mesopotamian Civilization: An Ethnoarchaeological Perspective on the Evolution of Social Complexity

The typological schemes constructed by many archaeologists to explain the rise and fall of civilizations have neither accounted for the processual changes involved in the evolution of social complexity nor contributed to the development of a comparative method for considering regularities and variation in social behavior. This paper begins with a review of the foundations on which archaeologists have based their conceptions of social evolution. A critical test of the assumptions of “evolutionism” is then provided by case studies in Mesopotamian civilization in which materials from both preliterate and literate times are examined. Using ancient, emic documentation that is recovered as part of the archaeological record, such studies may logically be termed ethnoarchaeological. It is suggested that the customary analogy between social change and biological evolution is inappropriate and that a new problem orientation will facilitate more productive research into the dynamics of social evolution. You would be surprised at the number of years it took me to see clearly what some of the problems were which had to be solved. Looking back, I think it was more difficult to see what the problems were than to solve them, as far as I have succeeded in doing, and this seems to me rather curious. Charles Darwin When we define a word we are merely inviting others to use it as we would like it to be used . the purpose of definition is to focus argument upon fact and . the proper result of good definition is to transform argument over terms into disagreements about fact, and thus open arguments to further inquiry. C. Wright Mills
Attentional networks in children and adolescents with autism spectrum disorder.

BACKGROUND Individuals diagnosed with autism spectrum disorder (ASD) exhibit lifelong abnormalities in the adaptive allocation of visual attention. The ubiquitous nature of attentional impairments in ASD has led some authors to hypothesize that atypical attentional modulation may be a factor in the development of higher-level sociocommunicative deficits. METHOD Participants were 20 children with ASD and 20 age- and Nonverbal IQ-matched typically developing (TD) children. We used the Attention Network Test (ANT) to investigate the efficiency and independence of three discrete attentional networks: alerting, orienting, and executive control. Additionally, we sought to investigate the relationship between each attentional network and measures of sociocommunicative symptom severity in children with ASD. RESULTS Results indicate that the orienting, but not alerting or executive control, networks may be impaired in children with ASD. In contrast to TD children, correlational analyses suggest that the alerting and executive control networks may not function as independently in children with ASD. Additionally, an association was found between the alerting network and social impairment and between the executive control network and IQ in children with ASD. CONCLUSIONS The results provide further evidence of an impairment in the visuospatial orienting network in ASD and suggest that there may be greater interdependence of alerting and executive control networks in ASD. Furthermore, decreased ability to efficiently modulate levels of alertness was related to increased sociocommunicative deficits, suggesting that domain-general attentional function may be associated with ASD symptomatology.
Sex–specific, counteracting responses to inbreeding in a bird

Inbreeding often depresses offspring fitness. Because females invest more than males in a reproductive event, inbreeding is expected to be more costly to mothers than fathers, creating a divergence between the reproductive interests of each sex and promoting sex–specific inbreeding strategies. Males and females may bias the probability of inbreeding by selecting copulation partners, and, in sexually promiscuous species, through male strategic sperm investment in different females and female selection of the sperm of different males. However, these processes are often difficult to study, and the way that different male and female strategies interact to determine inbreeding remains poorly understood. Here we demonstrate sex–specific, counteracting responses to inbreeding in the promiscuous red junglefowl, Gallus gallus. First, a male was just as likely to copulate with his full–sib sister as with an unrelated female. In addition, males displayed a tendency to: (i) initiate copulation faster when exposed to an unrelated female than when exposed to a sister, and (ii) inseminate more sperm into sisters than into unrelated females. Second, females retained fewer sperm following insemination by brothers, thus reducing the risk of inbreeding and counteracting male inbreeding strategies.
Double-Stranded RNA Is Produced by Positive-Strand RNA Viruses and DNA Viruses but Not in Detectable Amounts by Negative-Strand RNA Viruses

ABSTRACT Double-stranded RNA (dsRNA) longer than 30 bp is a key activator of the innate immune response against viral infections. It is widely assumed that the generation of dsRNA during genome replication is a trait shared by all viruses. However, to our knowledge, no study exists in which the production of dsRNA by different viruses is systematically investigated. Here, we investigated the presence and localization of dsRNA in cells infected with a range of viruses, employing a dsRNA-specific antibody for immunofluorescence analysis. Our data revealed that, as predicted, significant amounts of dsRNA can be detected for viruses with a genome consisting of positive-strand RNA, dsRNA, or DNA. Surprisingly, however, no dsRNA signals were detected for negative-strand RNA viruses. Thus, dsRNA is indeed a general feature of most virus groups, but negative-strand RNA viruses appear to be an exception to that rule.
H‐ras gene mutations in salivary gland mucoepidermoid carcinomas

The authors' recent investigation of salivary gland tumors in ras gene alteration has suggested that K‐ras activation may not play a role in their oncogenesis but H‐ras may, especially in mucoepidermoid carcinomas. A study was undertaken to assess the overall incidence of mutated H‐ras genes in mucoepidermoid carcinomas and to discover its potential correlation with clinicopathologic parameters.
Proportion of influenza cases in severe acute respiratory illness in Indonesia during 2008-2009

Aim: To access the proportion of Influenza which caused SARI cases Methods: From April 2008 until March 2009, 549 samples of nasal and throat swabs were collected from SARI patients from eight hospitals in eight provinces in Indonesia. The samples were analyzed for Influenza by real-time RT-PCR method using several specific primers for influenza A (A/H1N1, A/H3N2 and A/H5N1) and Influenza B. The sequence of these primers was provided by CDC, Atlanta. Results: We found 516 (94%) of the specimens testing results were not infl uenza A or B viruses. There was 21 (4%) cases caused by influenza A and 12 (2%) caused by influenza B. From the influenza A cases, one case of SARI was caused by A/H1N1, two cases were A/H5N1, 17 cases were A/H3N2 and one case was unsubtypeable Influenza A. Conclusion: The majority of SARI cases were not caused by influenza viruses. From this surveillance the most common influenza A related to SARI is A/H3N2. Facts of the avian influenza virus A/H5N1 cases have been found in Indonesia and the spread of novel virus influenza A/H1N1 in 2009 raised our concern about the importance of SARI surveillance. (Med J Indones 2010; 19:264-7) Keywords: influenza, severe acute respiratory illness
The Employment of Mothers: Recent Developments and Their Determinants in East and West Germany

We apply German Mikrozensus data for the period 1996 to 2004 to investigate the employment status of mothers. Specifically, we ask whether there are behavioral differences between mothers in East and West Germany, whether these differences disappear over time, and whether there are differences in the developments for high vs. low and medium skilled females. We find substantial differences in the employment behavior of East and West German mothers. German family policy sets incentives particularly for low income mothers not to return to the labor market after birth. East German mothers' employment outcomes matches that expected based on these policy incentives: over time East German mothers with low earnings potentials appear to adopt West German low employment patterns.
Adopting Design Thinking in Novice Multidisciplinary Teams: The Application and Limits of Design Methods and Reflexive Practices

Scholarly and practitioner literature have both described the potential benefits of using methods associated with a “design thinking” approach to develop new innovations. Most studies of the main design thinking methods—needfinding, brainstorming, and prototyping—are based either on analyses of experienced designers or examine each method in isolation. If design thinking is to be widely adopted, less-experienced users will employ these methods together, but we know little about their effect when newly adopted. Drawing on perspectives that consider concept development as broadly consisting of a divergent concept generation phase followed by a convergent concept selection phase, we collected data on fourteen cases of novice multidisciplinary product development teams using design methods across both phases. Our hybrid qualitative and quantitative analysis indicate both benefits and limits of formal design methods: First, formal design methods were helpful not only during concept generation but also during concept selection. Second, while brainstorming was valuable when combined with other methods, increased numbers of brainstorming sessions actually corresponded to lower performance, except in the setting where new members may join a team. And third, increased team reflexivity—such as from debating ideas, processes, or changes to concepts—was associated with more successful outcomes during concept generation but less successful outcomes during concept selection. We develop propositions related to the contingent use of brainstorming and team reflexivity depending on team composition and phase of development. Implication from this study include that novice multidisciplinary teams are more likely to be successful in applying design thinking when they can be guided to combine methods, are aware of the limits of brainstorming, and can transition from more- to less-reflexive practices.
The Impact of Tuition Increases on Enrollment at Public Colleges and Universities

In this paper we review recent increases in tuition at public institutions and estimate impacts on enrollment. We use data on all U.S. public 4-year colleges and universities from 1991 to 2006 and illustrate that tuition increased dramatically beginning in the early part of this decade. We examine impacts of such increases on total enrollment and credit hours, and estimate differences by type of institution. We estimate that the average tuition and fee elasticity of total headcount is -0.0958. At the mean, a $100 increase in tuition and fees would lead to a decline in enrollment of about 0.25 percent, with larger effects at Research I universities. We find limited evidence that especially large tuition increases elicit disproportionate enrollment responses.
Behavior of platinum/tantalum as interdigital transducers for SAW devices in high-temperature environments

In this paper, we report on the use of tantalum as adhesion layer for platinum electrodes used in high-temperature SAW devices based on langasite substrates (LGS). Tantalum exhibits a great adhesive strength and a very low mobility through the Pt film, ensuring a device lifetime at 900°C of about one hour in an air atmosphere and at least 20 h under vacuum. The latter is limited by morphological modifications of platinum, starting with the apparition of crystallites on the surface, followed by important terracing and breaking of the film continuity. Secondary neutral mass spectroscopy (SNMS), Auger electron spectroscopy (AES), X-ray diffraction (XRD) measurements, and comparison with iridium-based electrodes allowed us to show that this deterioration is likely intrinsic to platinum film, consisting of agglomeration phenomena. Finally, based on these results, we present a solution that could significantly enhance the lifetime of Pt-based IDTs placed in high-temperature conditions.
Peripapillary Nerve Fiber Layer Thickness Measured by Optical Coherence Tomography in Patients With No Light Perception From Long-Standing Nonglaucomatous Optic Neuropathies

Background: The residual peripapillary retinal nerve fiber layer thickness (PRNFLT) corresponding to no light perception vision from long-standing nonglaucomatous optic neuropathies has not been documented. Such a benchmark would be useful information because PRNFLT is being used as an indicator of the visual recovery potential in patients with optic neuropathies. Methods: By means of optical coherence tomography (OCT) using a fast RNFL thickness protocol, we determined the PRNFLT in 8 patients with no light perception (NLP) for at least 1 year from acquired nonglaucomatous optic neuropathies. All patients underwent an assessment of visual acuity, color vision, visual field, pupillary reactions to light stimulation, and ophthalmoscopy. Results: Four of the 8 patients had a normal fellow eye. The average PRNFLT in the 4 normal eyes was 97.90 μm (range 94.82-100.89 μm), whereas the average PRNFLT in 8 of the 9 eyes with NLP was 45.42 μm (range 37.65-51.46 μm). Conclusions: Eyes with long-standing NLP vision from nonglaucomatous optic neuropathies retain a residual PRNFLT of about 45 μm as measured by OCT. This should be taken into consideration when using PRNFLT to assess visual prognosis in patients with poor vision from various optic neuropathies.
The prevalence of personality disorders in a community sample.

BACKGROUND To our knowledge, no previous studies of personality disorders (PDs) in a large representative sample of the common population have been conducted. METHODS A representative sample of 2053 individuals between the ages of 18 and 65 years in Oslo, the capital of Norway, was studied from 1994 to 1997. Information about PDs was obtained by means of the Structured Interview for DSM-III-R Personality Disorders, in conjunction with an interview recording demographic data. The subjects were interviewed primarily at home, but in some instances, also at the clinic. RESULTS The prevalence of PDs was 13.4% (SE, 0.7). The prevalence rates (SEs) for specific PDs, irrespective of whether a person had 1 or more PD, were: paranoid, 2.4% (0.3); schizoid, 1.7% (1.6); schizotypal, 0.6% (0.2); antisocial, 0.7% (0.2); sadistic, 0.2% (0.1); borderline, 0.7% (0.2); histrionic, 2.0% (0.3); narcissistic, 0.8; (0.2); avoidant, 5.0% (0.5); dependent, 1.5% (0.3); obsessive-compulsive: 2.0% (0.3); passive-aggressive, 1.7% (0.3); self-defeating, 0.8%, (0.2). The prevalence of PDs was highest among subjects with only a high school education or less, and living without a partner in the center of the city. CONCLUSIONS Personality disorders were found to be prevalent, with avoidant, schizoid, and paranoid PDs more common, and borderline PD less common than what is usually reported. Personality disorders tend to be more frequent among single individuals from the lower socioeconomic classes in the center of the city. It is impossible to determine what is cause and what is consequence from a cross-sectional study.
Adiponectin deficiency protects mice from chemically induced colonic inflammation.

BACKGROUND & AIMS Adiponectin (APN) is an adipokine that regulates insulin sensitivity and is anti-inflammatory in atherosclerosis. The goal of this study was to investigate the role of APN in intestinal inflammation. METHODS APN knockout (KO) mice and their wild-type (WT) littermates received dextran sulfate sodium (DSS) or trinitrobenzene sulfonic acid (TNBS) to induce intestinal inflammation. Clinical and histologic scores and proliferation of epithelial cells were assessed. Cytokines and APN levels were measured. Expression of APN and heparin binding epidermal growth factor (HB-EGF) was analyzed by immunohistochemistry. Expression of APN and its receptors, HB-EGF, and basic fibroblast growth factor (bFGF) messenger RNA was assessed by reverse-transcription polymerase chain reaction. Association of serum APN with HB-EGF and bFGF was studied by coimmunoprecipitation. RESULTS APN KO mice are protected from chemically induced colitis; administration of APN restores inflammation. APN is expressed in the colon, luminal APN associates with colonic epithelial cells. In vitro, APN increases production of proinflammatory cytokines from colonic tissue. Expression of colonic APN overlaps with that of bFGF and HB-EGF, which play a protective role in colitis. Circulating APN binds to bFGF and HB-EGF, likely inhibiting their protective activity. Inhibition of EGF receptor signaling, which is required for biologic activity of HB-EGF, restores inflammation in APN KO mice. CONCLUSIONS APN deficiency is associated with protection from chemically induced colitis. APN exerts proinflammatory activities in the colon by inducing production of proinflammatory cytokines and inhibiting bioactivity of protective growth factors. Thus, in colitis, APN exerts an opposite role compared with atherosclerosis.