Miracle-dz/UniFAR-FTUs huggingface dataset:
Repeatable Battery for the Assessment of Neuropsychological Status: Effort Index Cutoff Scores for Psychometrically Defined Malingering Groups in a Military Sample.

OBJECTIVE This research examined cutoff scores for the Effort Index (EI), an embedded measure of performance validity, for the Repeatable Battery for the Assessment of Neuropsychological Status. EI cutoffs were explored for an active-duty military sample composed mostly of patients with traumatic brain injury. METHOD Four psychometrically defined malingering groups including a definite malingering, probable to definite malingering, probable malingering, and a combined group were formed based on the number of validity tests failed. RESULTS Excellent specificities (0.97 or greater) were found for all cutoffs examined (EI ≥ 1 to EI ≥ 3). Excellent sensitivities (0.80 to 0.89) were also found for the definite malingering group. Sensitivities were 0.49 or below for the other groups. Positive and negative predictive values and likelihood ratios indicated that the cutoffs for EI were much stronger for ruling-in than ruling-out malingering. Analyses indicated the validity tests used to form the malingering groups were uncorrelated, which serves to enhance the validity of the formation of the malingering groups. CONCLUSIONS Cutoffs were similar to other research using samples composed predominantly of head-injured individuals.
Trabeculectomy: The success rate and its factors among glaucoma patients in Kelantan, Malaysia

Trabeculectomy success rate among Asians is not too promising. Thus, a survival analysis among our local population is very important to help future strategy of glaucoma patient management. Objective: To determine the five year trabeculectomy success rate among glaucoma patient treated at Hospital Universiti Sains Malaysia. Methodology: A retrospective record review study was conducted involving 96 glaucoma patients (96 eyes) who underwent trabeculectomy from 1st January 1990 to 31st July 2006. Additional follow up of one year after the recruitment of the study subjects was done from 1st August 2006 to 31st July 2007. All patients who fulfilled the selections criteria were included in the study. The medical records were reviewed by a single researcher with the help of senior consultant of ophthalmology and important information on the variables of interest and trabeculectomy outcome status were collected and recorded into a clinic form. The Kaplan Meire analysis was used in statistical analysis. Results: The median trabeculectomy success time was 18.8 months and the overall trabeculectomy success rate was 36.1% (95% CI:25.6; 46.8) at five year. The patients without ocular surgery [42.2% (95% CI:30.3; 53.5)] demonstrated higher trabeculectomy success rate compared to those with previous ocular surgery [0% (95% CI: 0; 0)] prior to trabeculectomy at five year post trabeculectomy and the difference was statistically significant (p=0.008). Conclusion: Trabeculectomy success rate for glaucoma patients at HUSM was acceptably low. The used of antimetabolites during trabeculectomy is highly recommended in our population especially those with previous ocular surgery.
Harmonising non-financial reporting regulation in Europe

Purpose - Motivated by the new European Union Directive 2014/95 on non-financial and diversity information, this paper aims to develop a future research agenda to conduct pragmatic, theory-oriented research into the Directive and corporate sustainability reporting. Design/methodology/approach - Drawing upon the relational dynamics between states, firms and society in regulating non-financial reporting (NFR), this essay frames and analyses the Directive and its grand theories, as unproven theories, by discussing its practical concerns and reviewing the academic literature. Findings - The Directive is an act of policy to legitimise NFR that encompasses two grand theories: improve the comparability of information and enhance corporate accountability. From a pluralist perspective, companies can rest assure that their compliance with the Directive will be perceived as socially desirable, proper and appropriate. However, some of the forces involved in translating the Directive into actionable policies operate contra to the Directive’s goals and, instead, act as barriers to its grand theories. In addressing these barriers, a research agenda is proposed that both traces backward to re-examine the foundational theories of the past and looks forward to explore alternative possibilities for achieving these goals. Research limitations/implications - This paper provides researchers with a practical-driven and theory-oriented agenda for future research in light of the rising academic interest in the Directive. Practical implications - The barriers to the Directive’s grand theories help policymakers and practitioners to understand the practical concerns about the implementation of the Directive and other mandatory NFR policies. Originality/value - This paper enriches the emerging debate on the Directive and highlights future possibilities for fruitful empirical research by developing a research agenda.
Influence of Different Criteria for Abnormal Lymph Node Size on Reliability of Computed Tomography in Patients with Non-Seminomatous Testicular Tumor

The reliability of computed tomography (CT) using different criteria for abnormal size of retroperitoneal lymph nodes (5, 10, 15 mm in largest diameter) was evaluated prospectively in 90 consecutive patients with a non-seminomatous testicular tumor and lymph nodes less than 20 mm at CT. Correlation was made with histologic findings following retroperitoneal lymphadenectomy. Histologic examination revealed metastases in 38 patients (42%). Using a strict criterion of 15 mm for abnormal node size, sensitivity was 37%, specificity 98%, positive predictive value 93 % and negative predictive value 68 %. A relaxed criterion of 5 mm led to a sensitivity of 71 %, specificity 67%, positive predictive value 61 % and negative predictive value 76%. Overall accuracy was approximately 70% with the 5, 10 and 15 mm criteria for abnormal size. The inability of a normal scan to exclude metastases was the main limitation of CT.
Is 18F-FDG-PET suitable to predict clinical response to the treatment of geriatric depression? A systematic review of PET studies

ABSTRACT Background: Geriatric depression is one of the most common psychiatric disorders in later life. It differs from earlier depression in its presentation, etiology, risk factors, protective factors and outcome. Positron emission tomography (PET) can be used to detect changes in neural circuitry in neuropsychiatric disorders, and several authors have assessed its role in the diagnosis and follow-up of patients with geriatric depression. We reviewed the current evidence on the use of fluorine-18-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) in geriatric depressed patients to find predictors of treatment response. Methods: We searched PubMed/MEDLINE, Scopus, Embase, Cochrane Library, CINAHL and the PsycINFO databases to find relevant peer-reviewed articles on PET in geriatric depression using the search terms (‘PET’ or ‘positron emission tomography’) and (‘mood’ or ‘affective disorder’ or ‘affective disorders’ or ‘depression’ or ‘dysthymia’ or ‘seasonal affective disorder’). Results: Eleven articles comprising 128 patients were included. We extracted data on glucose uptake of depressed patients and controls at baseline and after different types of intervention (total sleep deprivation followed by a recovery sleep and treatment with selective serotonin reuptake inhibitors). Conclusions: 18F-FDG-PET showed significant alterations of glucose uptake in several brain areas, in particular the anterior cingulate cortex, which showed reduced metabolism after treatment, and was a predictor of treatment response.
Physicochemical properties and composition of snakehead fish (Channa striatus) whole fillet powder prepared with pre-filleting freezing treatments.

Channa striatus (“haruan”) fish destined for fillet preparation was subjected to two freezing treatments, freezing with distilled water (FW) or freezing directly without distilled water (DF). Fish that was freshly processed without freezing served as control (C). Fillet yield (%) was in the range 33.8% to 35.3% and the highest yield was recorded in FW samples. Whole Fillet Powder (WFP) was prepared from the fillets through low temperature vacuum oven drying (50°C) and its composition and physicochemical properties were assessed. There was no significant difference in moisture and protein contents of all samples (p > 0.05). All WFP were generally dark in colour with whiteness indices ranging from 55.23 63.98. The redness (a*) values were 4.33, 11.12, 8.83 whilst the yellowness (b*) were 19.31, 23.04, 21.20 for C, WFPFW and WFP-DF respectively. WFPs were generally high in histidine, arginine, threonine and tyrosine when compared to egg whites and these (except histidine) and other amino acids (serine, glycine, methionine and phenylalanine) were significantly higher (p < 0.05) in WFPFW compared to other samples. Overall, freezing treatments affected the composition and physicochemical properties of WFPs.
Identifying Banking Crises

We identify historical banking crises in 46 countries over the period 1870 2016 using new historical data on bank equity returns. We argue bank equity crashes provide an objective, quantitative, and theoretically-motivated measure of banking crises. We validate our measure by showing that bank equity crashes line up well with other indicators of banking crises (e.g., panics, bank failures, government intervention). They also forecast long-run output gaps. Bank equity declines tend to pick up impending crises first before credit spread and nonfinancial equity measures. Nevertheless, crises gradually unfold in bank equity prices over one to three years, rather than in sudden Minsky moments. Our approach uncovers several newly-identified banking crises and removes spurious banking crises. Comparing our revised chronology to previous ones, the aftermath of banking crises appears more severe, especially when restricting to crises featuring large bank equity declines. * The authors would like to thank William Shao and Bryan Tam for their extraordinary research assistance. Isha Agarwal, Isaac Green, Md Azharul Islam, Jamil Rahman, Felipe Silva, and the librarians at the Harvard Business School Historical Collections also provided valuable assistance. The authors would also like to thank Mikael Juselius and seminar participants at Cornell University and the 2018 AEA meetings for their comments and feedback. We thank Mika Vaihekoski for sharing data. ** Contact information: Matthew Baron, Johnson Graduate School of Management, Cornell University, baron@cornell.edu; Emil Verner, Princeton University, verner@princeton.edu; Wei Xiong, Princeton University and NBER, wxiong@princeton.edu.
Factors Associated with the Combined Use of Antidepressants and Benzodiazepines in Major Depression: A Case–Control Study

The aim of this study was to identify the factors associated with the combined use of antidepressants and benzodiazepines (BDZs) in patients with major depression. We conducted a case–control study in the public health service of the city of São Paulo, Brazil. The participants were all patients being treated with antidepressants, who were diagnosed with major depression. Patients who received a combination of antidepressants and BDZs were classified as cases, and those who used only antidepressants, as controls. Data were obtained from a pharmacy database, medical records and interviews with the healthcare team. The association of predisposing factors for combined therapy was analysed using logistic regression analysis, and the odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Of the 1355 users of antidepressants, 265 had major depression, of whom 138 were cases and 127 were controls. The factors associated with combined use were age older than 35 years (OR 2.2, 95% CI 1.0–4.7), absence of comorbidities (OR 2.3, 95% CI 1.4–4.1) and no use of other drugs (OR 1.9, 95% CI 1.1–3.3). Patients with combined use were more likely to exhibit inadequate prescribing, including inappropriate antidepressants (OR 4.7, 95% CI 2.2–9.9), inadequate dosages (OR 3.62, 95% CI 1.4–9.6) and/or a non‐recommended duration (OR 66.6, 95% CI 18.4–240.7). The factors identified showed the groups most susceptible to combined use in this population, who in turn are more likely to receive inappropriate prescriptions.
A direct comparison of the antigen‐specific antibody profiles of intravenous immunoglobulins derived from US and UK donor plasma

Background and Objectives Intravenous immunoglobulin (IVIG) is used in a range of immunodeficiency states that require a broad spectrum of protective antibodies to a range of common pathogens. A comparison of the antigen‐specific antibody profile of preparations of an IVIG (Vigam®) derived from US and UK sourced plasma was performed, and these preparations were also compared with three other IVIG products from different manufacturers.
CT assessment of jugular foramen dominance and its association with hand preference

Abstract Three hundred and seven normal CT scans of the head were prospectively analysed to assess jugular foramen dominance. After assessment, hand preference was elicited. Of these, 276 were right-handed and 31 were left-handed. Of the right-handed patients: 180 had a larger jugular foramen on the right; 63 had a larger jugular foramen on the left; and in 33 no difference could be discerned. Of the left-handed patients: 11 had a larger jugular foramen on the right; 16 hada larger jugular foramen on the left; and in four no difference couldbe discerned. The results suggested a significant association betweenjugular foramen dominance and hand preference.
Survival and Quality of Life after Prolonged Intensive Care Unit Stay

There are few data on long-term outcomes in mixed groups of intensive care unit (ICU) patients with prolonged stays. We evaluated the relationship between length of stay in the ICU and long-term outcome in all patients admitted to our 31-bed department of medico-surgical intensive care over a one-year period who stayed in the department for more than 10 days (n=189, 7% of all ICU admissions). Mortality increased with length of stay from 1 to 10 days (1 day 5%, 5 days 15%, 9 days 24%, 10 days 33%) but remained stable at about 35% for longer ICU stays. In the long-stay patients, the most common reasons for ICU admission were intracranial bleeding (23%), polytrauma (14%), respiratory failure (13%) and septic shock (11%). The main reasons for prolonged ICU stay were ventilator dependency (40%), infectious complications (23%) and coma (16%). Long-stay patients had a 65% ICU survival, 55% hospital survival and 37% one-year survival. At one-year follow-up, 73% of surviving patients reported no or minor persistent physical complaints compared to before the acute illness; 27% had a major functional impairment, including 8% who required daily assistance. In conclusion, in ICU patients, mortality increases with length of stay up to 10 days. Patients staying in the ICU for more than 10 days have a relatively good long-term survival. Most survivors have an acceptable quality of life.
Bedtime Activities, Sleep Environment, and Sleep/Wake Patterns of Japanese Elementary School Children

Bedtime activities, sleep environment, and their impact on sleep/wake patterns were assessed in 509 elementary school children (6–12 years of age; 252 males and 257 females). Television viewing, playing video games, and surfing the Internet had negative impact on sleep/wake parameters. Moreover, presence of a television set or video game in the child's bedroom increased their activity before bedtime. Time to return home later than 8 p.m. from after-school activity also had a negative impact on sleep/wake patterns. Health care practitioners should be aware of the potential negative impact of television, video games, and the Internet before bedtime, and also the possibility that late after-school activity can disturb sleep/wake patterns.
BRAFV600E mutation contributes papillary thyroid carcinoma and Hashimoto thyroiditis with resistance to thyroid hormone: A case report and literature review

Resistance to thyroid hormone (RTH) is a rare autosomal hereditary disorder characterized by increased serum thyroid hormone (TH) levels with unsuppressed or increased thyrotropin concentration. It remains unknown whether the coexistence of RTH with papillary thyroid carcinoma (PTC) and Hashimoto thyroiditis (HT) is incidental or whether it possesses a genetic or pathophysiological association. In the present study, a case of RTH with PTC and HT in an 11-year-old Chinese patient was examined and the clinical presentation of RTH with PTC was discussed. In addition, the possible associations between RTH, PTC and HT were determined. HT was confirmed in the patient using an autoimmune assay and thyroid ultrasound. RTH was diagnosed on the basis of clinical manifestations, laboratory information and gene analysis, and PTC was diagnosed according to histological results. Results of BRAFV600E mutation analysis were positive. A literature review of 14 cases of RTH with PTC was included for comparison. The present case report indicates an association of RTH with PTC and HT coexistence in the patient. Close follow-up, histological evaluation and BRAFV600E mutation detection should be performed in each RTH case with HT, since a persistent increase in TSH may be a risk factor for the development of thyroid neoplasm.
Inhibition of cholinergic pathways in Drosophila melanogaster by α‐conotoxins

Nicotinic acetylcholine receptors (nAChRs) play a pivotal role in synaptic transmission of neuronal signaling pathways and are fundamentally involved in neuronal disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. In vertebrates, cholinergic pathways can be selectively inhibited by α‐conotoxins; we show that in the model organism Drosophila, the cholinergic component of the giant fiber system is inhibited by α‐conotoxins MII, AuIB, BuIA, EI, PeIA, and ImI. The injection of 45 pmol/fly of each toxin dramatically decreases the response of the giant fiber to dorsal longitudinal muscle (GF‐DLM) connection to 20 ± 13.9% for MII; 26 ± 13.7% for AuIB, 12 ± 9.9% for BuIA, 30 ± 11.3% for EI, 1 ± 1% for PeIA, and 34 ± 15.4% for ImI. Through bioassay‐guided fractionation of the venom of Conus brunneus, we found BruIB, an α‐conotoxin that inhibits Drosophila nicotinic receptors but not its vertebrate counterparts. GF‐DLM responses decreased to 43.7 ± 8.02% on injection of 45 pmol/fly of BruIB. We manipulated the Dα7 nAChR to mimic the selectivity of its vertebrate counterpart by placing structurally guided point mutations in the conotoxin‐binding site. This manipulation rendered vertebrate‐like behavior in the Drosophila system, enhancing the suitability of Drosophila as an in vivo tool to carry out studies related to human neuronal diseases. —Heghinian, M. D. , Mejia, M. , Adams, D. J., Godenschwege, T. A. , Marí, F. , Inhibition of cholinergic pathways in Drosophila melanogaster by α‐conotoxins. FASEB J. 29, 1011–1018 (2015). www.fasebj. org
The motives behind dividend policy

The puzzle for dividend policy in Indonesia is still remain since the firms have uncertain distribution for dividends to their shareholders. The objectives of this study are testing the free cash flow theory, life cycle theory, and catering theory with 139 firms as samples which is listed in Indonesia Stock Exchange for period of 2010 to 2015. This study finds that, firms in Indonesia are not at mature level and there is an existence for free cash flow effect on dividend payers with lower debt only, while catering effect is generally exist for firms as dividend payers. Furthermore, since the firms as non dividend payers are on growth level then they are generally use their profit and capital gain includes debts in purposes of investment activities. Keywords : dividend policy, free cash flow, life cycle, catering
Extended cognitive behavior therapy for cigarette smoking cessation.

UNLABELLED PRIMARY AIM: Examine the effectiveness of extended cognitive behavior therapy (CBT) in promoting longer-term smoking abstinence. DESIGN Open-label treatment phase followed by extended treatment phase. Randomization conducted prior to entry into open-label treatment phase; analysis based on intention-to-treat to avoid threat of selection bias. SETTING Community smoking cessation clinic. PARTICIPANTS A total of 304 adult smokers (> or = 18 years of age; > or = 10 cigarettes/day). INTERVENTION Open-label (8 weeks): all participants received bupropion SR, nicotine patch, CBT. Extended treatment (12 weeks): participants received either CBT + voicemail monitoring and telephone counseling or telephone-based general support. MEASUREMENTS Seven-day point prevalence abstinence, expired-air carbon monoxide. RESULTS At week 20 follow-up, CBT produced a higher 7-day point prevalence abstinence rate: 45% versus 29%, P = 0.006; at 52 weeks the difference in abstinence rates (31% versus 27%) was not significant. History of depression was a moderator of treatment. Those with a positive history had a better treatment response at 20 weeks when assigned to the less intensive telephone support therapy (P < 0.05). CONCLUSION The superiority of CBT to 20 weeks suggests that continued emphasis on the development of cognitive and behavioral strategies for maintaining non-smoking during an extended treatment phase may help smokers to maintain abstinence in the longer term. At present, the minimum duration of therapy is unknown.
Attenuation of gentamicin-induced nephrotoxicity in rats by fleroxacin

The effect of fleroxacin on gentamicin-induced nephrotoxicity was evaluated with female Sprague-Dawley rats. Animals were injected during 4 or 10 days with saline (NaCl; 0.9%), gentamicin alone at doses of 10 and 40 mg/kg of body weight/12 h (subcutaneously), fleroxacin alone at a dose of 25 mg/kg/12 h (intraperitoneally), or the combination gentamicin-fleroxacin in the same regimen. Gentamicin induced a dose- and time-dependent renal toxicity as evaluated by gentamicin cortical levels, sphingomyelinase activity in the renal cortex, histopathologic and morphometric analysis, blood urea nitrogen and serum creatinine levels, and cellular regeneration ([3H]thymidine incorporation into DNA of cortical cells). The extent of these changes was significantly reduced when gentamicin was given in combination with fleroxacin. Although the mechanisms by which fleroxacin reduces the nephrotoxic potential of gentamicin are unknown, we propose that the fleroxacin-gentamicin combination enhances exocytosis activity in proximal tubular cells, as suggested by the higher excretion of urinary enzymes and lower cortical levels of gentamicin observed in animals treated with the combination fleroxacin-gentamicin compared with those treated with gentamicin alone. The protective effect of fleroxacin on gentamicin nephrotoxicity should be investigated further.