Miracle-dz/UniFAR-FTUs huggingface dataset:
Social Network Services in China: An Integrated Model of Centrality, Trust, and Technology Acceptance

Abstract The rapid development of web-based Social Network Services (SNS) in China has been remarkable over the past several years. SNS allow users to build and nurture social connections over wide geographic areas. A distinct interaction between users' experience of service and their social networking behavior is at the heart of SNS business. Previous research in e-commerce and e-government has established that users' intentions are the result of both user perceptions of the technology (e.g., perceived usefulness and ease of use) and trust in technology providers. However, Social Network Services (SNS) are unique because they contain features that are not found in other electronic services. Our research of Chinese SNS users shows that centrality, technology acceptance, familiarity, and user trust are important to SNS market penetration. Together, these variables explain a significant proportion of variance in users' intention of using e-socializing services. Our findings suggest that SNS providers should re-examine their overall strategies using factors such as the number of social ties, channel of service promotion, and web interface design.
Abnormal spatial QRS-T angle, a marker of ventricular repolarisation, predicts serious ventricular arrhythmia in systemic sclerosis.

OBJECTIVES Cardiac involvement may be under-diagnosed in asymptomatic patients with systemic sclerosis (SSc). Standard electrocardiography-derived spatial QRS-T angle (spQRS-Ta) is an established marker of ventricular repolarisation heterogeneity, and a strong independent predictor of cardiac morbidity and mortality, including sudden death, in the general population. We examined whether spQRS-Ta is abnormal in asymptomatic SSc patients and assessed its predictive value for possibly concurrent, serious ventricular arrhythmia. METHODS SpQRS-Ta and 24-hour Holter recordings were obtained from 69 SSc patients (aged 51±13 years, 63 women) without clinically evident cardiac involvement and having left ventricular ejection fraction at least 50% by echocardiography. 'Healthy' subjects matched 1:1 with patients for age, gender and body mass index served as controls. RESULTS SpQRS-Ta was wider in SSc (median value 15.6°, interquartile range 10.6-24.3°) than controls (10.5°, 7.3-13.5°, p=0.0001) and not associated with skin fibrosis extent or specific clinical manifestations and autoantibodies. Twenty-four-hour Holter recordings revealed couplets of ventricular beats in six (Lown class IVa) and non-sustained ventricular tachycardia in five patients (Lown class IVb); spQRS-Ta was wider in those eleven patients with serious ventricular arrhythmia than the remaining patients (24.9°, 14.9-31.3° vs. 14.4°, 9.6-22.3°; p=0.02). A spQRS-Ta>19.3° demonstrated 80% sensitivity and 68% specificity (area under the curve 0.81, p=0.02) to predict the presence of non-sustained ventricular tachycardia in Holter monitoring. CONCLUSIONS Ventricular repolarisation heterogeneity, as reflected by wider spQRS-Ta, is common in SSc. Increased spQRS-Ta could serve as a simple screening test for further investigation to identify patients at risk or prone to develop life-threatening ventricular arrhythmia.
Nicotine does not enhance discrimination performance in a temporal bisection procedure

Recent reports of selective disruption of stimulus control by drug administration and other disruptive operations in temporal discrimination procedures may be interpreted as a disruption of attention to the temporal sample stimuli. This experiment assessed the effects of nicotine, a compound that has been widely shown to increase measures of attention, on temporal discrimination performance. Pigeons responded under a psychophysical choice procedure in which responses to one key color were correct after presentation of four shorter sample durations and responses to another key color were correct after presentation of four longer sample durations. Performance under nicotine was characterized by using a model that differentiates the effects of nicotine on stimulus control, bias, and sensitivity of temporal discrimination. Nicotine selectively decreased the measure of stimulus control, but did not systematically affect the measures of timing. Mecamylamine (1.0 mg/kg) failed to antagonize the disruptive effects of nicotine. These results suggest that disruption of temporal discrimination performance in this preparation may not have been dependent on the specific pharmacology of nicotine and underscore the importance of quantitative separation of the effects of various manipulations on stimulus control from effects on timing.
Vitreous levels of vascular cell adhesion molecule and vascular endothelial growth factor in patients with proliferative diabetic retinopathy: a case-control study.

OBJECTIVE To evaluate the intravitreous concentration of vascular cell adhesion molecule (VCAM)-1 in diabetic patients with proliferative diabetic retinopathy (PDR) and the relationship of VCAM-1 with vascular endothelial growth factor (VEGF). RESEARCH DESIGN AND METHODS Serum and vitreous fluid samples were obtained simultaneously at the onset of vitrectomy from 20 diabetic patients with PDR and 20 nondiabetic control subjects with nonproliferative ocular disease. Both groups were matched by serum levels of VCGM-1 and VEGF. VCAM-1 and VEGF were determined by enzyme-linked immunosorbent assay. Statistics were determined using the Mann-Whitney U test and Spearman's rank correlation test. RESULTS The intravitreous concentration of VCAM-1 was signifcantly elevated in diabetic patients with PDR compared with control subjects (26 ng/ml [19-118] vs. 22 ng/ml [20-47], P < 0.05). A direct correlation between VCAM-1 and total vitreous proteins was detected in diabetic patients (r = 0.64, P = 0.003), but not in control subjects. After adjusting for total intravitreous proteins, VCAM-1 was significantly lower in diabetic patients with PDR than in control subjects (8.2 ng/ml [4-31.4] vs. 43.1 ng/ml [9.7-100], P < 0.001). Intravitreous VEGF concentrations were higher in patients with PDR than in control subjects in absolute terms (1.34 ng/ml [0.16-6.22] vs. 0.009 ng/ml [0.009-0.044], P < 0.0001) and after correcting for total vitreal proteins (0.33 ng/ml [0.01-2.3] vs. 0.013 ng/ml [0.003-0.035], P = 0.0001). Finally, the vitreous ratio of VCAM-1 to proteins correlated with the vitreous ratio of VEGF to proteins in both diabetic patients (r = 0.74, P = 0.001) and control subjects (r = 0.84, P = 0.005). CONCLUSIONS The low proportion of VCAM-1 in relation to total vitreal proteins observed in diabetic patients with PDR suggests that VCAM-1 is quenched by diabetic retina. In addition, the direct correlation detected between VCAM-1 and VEGF suggests that cellular adhesion and neovascularization may be linked processes.
Non-binding Defaults and Voluntary Contributions to a Public Good - Clean Evidence from a Natural Field Experiment

We conducted a large scale field experiment to test whether framing a voluntary contribution decision with different non-binding defaults affect people's behavior. On an electricity provider's website, we manipulated non-binding green energy defaults in electricity contract offers. The default was either green or non-green. Buying green is costly and protects the environment. Hence, it is a voluntary contribution to a public good. Our core results are: First, defaults have a strong effect on contributions. 69% of new customer buy green, when the default was green, but only 7% when the default was nongreen. Second, the fraction of website visitors signing an electricity contract is similar across treatments. Third, regional election results affect green energy choice of customers.
Concentration Of Cortisol Metabolites In Captive Sumatran Elephants At Elephant Conservation Facilities In Aceh

This study was conducted to validate the DRG Cortisol ELISA EIA-1887 Germany kit for measure the concentration of stress hormone metabolites (cortisol) from the feces and its correlation to the stressor factor in captive elephants in PKG and CRU of Aceh. These factors are location, diet and presence of livestock. There is no special treatment, observation based on the activity, behavior or natural condition of the animals. The sampling technique was non invasive, fresh dung samples of each (±20 gram) were collected from 25 elephants in CRU and PKG. Feces taken in the morning (before the animals are bathed) along with the observation of animal behavior. All samples were collected and stored at -200C until the analysis process. The validation test are analytic (parallelilmsm) and biological validation test. The analytic test result (paralillsm), showed that the sample curve was not parallel to the standard curve, but crossed the standard curve. While the results of biological validation test, DRG Cortisol ELISA EIA-1887 Germany kit can measure the concentration of cortisol hormone feces of Sumatran elephant and able to describe the difference of cortisol concentration relation to physiological events (stress vs non-stress). The mean values of cortisol metabolite concentrations from PKG Saree (Komplek PKG and Hutan Seunapet), Sampoiniet CRU, Cot Girek, Das Peusangan, Meulaboh and Aceh Timur were (577 ng/g and 400 ng/g), 435ng /g, 419ng /g, 517ng / g, 401ng/g and 425ng /g. The measurement results correlate with the physiological conditions and observed factors.
The long history of financial boom-bust cycles in Iceland - Part II: Financial cycles

Iceland suffered a severe financial crisis in 2008 which can only be described as the perfect storm, with the currency falling by more than 50% and over 90% of the domestic financial system collapsing. What followed was a deep recession. This was not the first financial crisis experienced in Iceland, however. In fact, over a period spanning almost one and a half century (1875-2013), we identify over twenty instances of financial crises of different types. Recognising that crises tend to come in clusters, we identify six serious multiple financial crisis episodes occurring every fifteen years on average. These episodes seem to share many commonalities and the tragic but universal truth that “we’ve been there before” when it comes to financial crises really becomes all too clear. We find that these episodes usually involve a large collapse in domestic demand that in most cases serves as a trigger for theensuing crisis. What typically follows is a currency crisis, sometimes coinciding with a sudden stop of capital inflows and an inflation crisis, and most often a banking crisis. In line with international evidence, we find that contractions coinciding with these large financial crises tend to be both deeper and longer than regular business cycle downturns. Although the crisis episodes share many common elements, each one of them is also different to some extent. We are therefore not able to find financial variables that consistently provide an early-warning signal of an upcoming financial crisis across all the six episodes. However, we find that some key macroeconomic variables give a somewhat more robust signal. Our results also suggest that five of the six multiple crisis episodes coincide with a global financial crisis of some type, and that the most serious global episodes coincide with a twoto threefold increase in the probability of a financial crisis in Iceland. A companion paper (Part II) extends our analysis of the Icelandic financial boom-bust cycle to identifying financial cycles in our long data set, i.e. cycles that are of lower frequency and last longer than common business cycles and are characterised by co-movement of many key financial variables and often have peaks closely associated with financial crises.
Selective Losses of Brainstem Catecholamine Neurons After Hypoxia-Ischemia in the Immature Rat Pup

Hypoxic-ischemic (HI) injury in the preterm neonate incurs numerous functional deficits, however little is known about the neurochemically-defined brain nuclei that may underpin them. Key candidates are the brainstem catecholamine neurons. Using an immature animal model, the postnatal day (P)-3 (P3) rat pup, we investigated the effects of HI on brainstem catecholamine neurons in the locus coeruleus, nucleus tractus solitarius (NTS), and ventrolateral medulla (VLM). On P21, we found that prior P3 HI significantly reduced numbers of catecholaminergic neurons in the locus coeruleus, NTS, and VLM. Only locus coeruleus A6, NTS A2, and VLM A1 noradrenergic neurons, but not NTS C2 and VLM C1 adrenergic neurons, were lost. There was also an associated reduction in dopamine-beta-hydroxylase-positive immunolabeling in the forebrain. These findings suggest neonatal HI can affect specific neurochemically-defined neuronal populations in the brainstem and that noradrenergic neurons are particularly vulnerable to HI injury.
A1 Functions at the Mitochondria to Delay Endothelial Apoptosis in Response to Tumor Necrosis Factor*

Tumor necrosis factor (TNF) does not cause endothelial apoptosis unless the expression of cytoprotective genes is blocked. We have previously demonstrated that one of the TNF-inducible cytoprotective genes is the Bcl-2 family member, A1. A1 is induced by the action of the transcription factor, NFκB, in response to inflammatory mediators. In this report we demonstrate that, as with other cell types, inhibition of NFκB initiates microvascular endothelial apoptosis in response to TNF. A1 is able to inhibit this apoptosis over 24 h. We demonstrate that A1 is localized to and functions at the mitochondria. Whereas A1 is able to inhibit mitochondrial depolarization, loss of cytochrome c,cleavage of caspase 9, BID, and poly(ADP-ribose) polymerase, it does not block caspase 8 or caspase 3 cleavage. In contrast, A1 is not able to prevent endothelial apoptosis by TNF over 72 h, when NFκB signaling is blocked. On the other hand, the caspase inhibitor, benzyloxycarbonyl-VAD-formylmethyl ketone, completely blocks TNF-induced endothelial apoptosis over 72 h. Our findings indicate that A1 is able to maintain temporary survival of endothelial cells in response to TNF by maintaining mitochondrial viability and function. However, a mitochondria-independent caspase pathway eventually results in endothelial death despite mitochondrial protection by A1.
Adding to the controversy: Pitfalls in the diagnosis of testosterone deficiency syndromes with questionnaires and biochemistry

Purpose. To determine the value of available questionnaires used for the diagnosis of testosterone deficiency syndromes (TDS) by correlating their ratings with a panel of hormonal determinations in a male population. Materials and methods. Participants completed the ADAM questionnaire and underwent biochemical evaluation at the local site. Assessments determined entry into Group A (symptomatic) or Group B (non-symptomatic). After stratification, subjects provided a morning sample of blood, completed the Aging Male Survey (AMS) and the newly developed Canadian Society for the Study of the Aging Male (CSAM-Q) questionnaires. Serum aliquots were analysed at a central lab for 8 putative markers commonly associated with symptomatic testosterone deficiency associated with aging: total testosterone (T); bioavailable T (BT); dehydroepiandrosterone sulphate (DHEA-S); sex-hormone binding globulin (SHBG); luteinizing hormone (LH), prolactin (PRL); thyroid-stimulating hormone (TSH) and insulin-like growth factor-1 (IGF-1). Results. 92 men were screened; of these 59 (mean age of 58 ± 11 years) completed the study, 30 (51%) scored positively (mean 61.5 years) to the ADAM while 29 (49%) did not (mean 54.1 years). For the AMS the weight of the three domains (psychological, somato-vegetative and sexual) was significantly greater in Group A (p < 0.001) than in Group B. Equally, for the CAS questionnaire, the scores for the variables energy, global performance, frequency of intercourse, mood and quality of sleep were lower in Group A than in their asymptomatic counterparts (p < 0.001). The domain of memory assessment within the CSSAM-Q was not discriminatory. ADAM and AMS are self-administered and completed within 10 minutes. CSSAM-Q is more time consuming, requires an investigator to administer, and memory domain is biased in favour of specific professional training. No difference was found between the two groups in 6 of 8 biochemical tests. However, significant lower values (p < 0.001) were found for DHEA-S and IGF-1 in the symptomatic group as compared with the non-symptomatic cohort. Conclusions. This study confirms that newer, more complex tools perform similarly to the simpler ADAM questionnaire. The lack of correlation between the clinical picture and the most commonly used biochemical confirmatory tests, again, clearly points to the paramount importance of the clinical evaluation. An emphasis and reliance on serum T alone hinders the clinician's ability to manage testosterone deficiency syndromes (TDS).
TRI HITA KARANA MENINGKATKAN KUALITAS MODAL MANUSIA DARI PERSFEKTIF KESEHATAN

Human capital contains the values found in the human beings themselves. Human capital has a value that can be used to live their life to become more comfortable. The level of health is a very important human capital as a fundamental support to be able to reflect other values in order to achieve successful society and individuals. Health as defined by the World Health Organization (WHO) which initially defined that healthy means to be physically, psychologically, socially healthy, and free of defects. However, It has been now added with spiritually healthy. The health of human capital is not only affected by genetics, health care facilities and infrastructure, as well as the environment, but also strongly influenced by the behavior or culture of human capital themselves, as well as the culture of the group in which human capital is located. Culture of Tri Hita Karana (THK) can improve the character of human capital by means of improving their health values.
Ser 18 and 23 phosphorylation is required for p 53-dependent apoptosis and tumor suppression

Mouse p53 is phosphorylated at Ser18 and Ser23 after DNA damage. To determine whether these two phosphorylation events have synergistic functions in activating p53 responses, we simultaneously introduced Ser18/23 to Ala mutations into the endogenous p53 locus in mice. While partial defects in apoptosis are observed in p53 and p53 thymocytes exposed to IR, p53-dependent apoptosis is essentially abolished in p53 thymocytes, indicating that these two events have critical and synergistic roles in activating p53-dependent apoptosis. In addition, p53, but not p53, could completely rescue embryonic lethality of Xrcc4 / mice that is caused by massive p53-dependent neuronal apoptosis. However, certain p53-dependent functions, including G1/S checkpoint and cellular senescence, are partially retained in p53 cells. While p53 mice are not cancer prone, p53 mice developed a spectrum of malignancies distinct from p53 and p53 / mice. Interestingly, Xrcc4 / p53 mice fail to develop tumors like the pro-B cell lymphomas uniformly developed in Xrcc4 / p53 / animals, but exhibit developmental defects typical of accelerated ageing. Therefore, Ser18 and Ser23 phosphorylation is important for p53-dependent suppression of tumorigenesis in certain physiological context. The EMBO Journal (2006) 25, 2615–2622. doi:10.1038/ sj.emboj. 7601167; Published online 1 June 2006 Subject Categories: development; differentiation & death
Modelling and simulation of an avionics full duplex switched Ethernet

Architectures of embedded avionics networks, such as that of the future Airbus A380, currently know important evolutions. This is principally due to the increase in the complexity of the embedded systems, in terms of the rise in the number of integrated functions and their connectivity. The evolution in the technologies of data transmission local area networks makes it possible to convey new answers to airframe manufacturers. In particular, switched Ethernet technologies are being implemented as an avionics architecture, even if the non-deterministic character of certain networks must be compensated by strong assumptions. The paper presents a simulation model for dimensioning an avionics full duplex switched Ethernet network (AFDX) and for studying the performance of this network. Comparison with other deterministic studies which use network calculus is also performed.
Patient Stage of Change predicts outcome in a panic disorder medication trial.

OBJECTIVE The authors test the hypothesis that patient readiness to change predicts outcome in a placebo-controlled medication trial. METHOD Out-patients with panic disorder and agoraphobia completed the Stages of Change (SOC) questionnaire, a measure of readiness to change, before being randomly assigned either sustained release (SR) adinazolam or placebo in a 4 week double-blind trial. RESULTS In the "intent to treat" analysis, for the 202 subjects who made at least one visit after baseline, adinazolam SR was significantly more effective than placebo on most major outcome measures. Of the 126 subjects who completed the SOC questionnaire, regression analyses showed significant correlations between SOC scores and all 5 outcome measures. In a second analysis, cluster membership based on SOC scores was predictive of outcome on 3 of 5 measures. In each statistical analysis, subjects who were not predisposed to change as measured by the SOC were significantly less likely to change. CONCLUSIONS Patient readiness to change was strongly correlated with outcome in a placebo-controlled panic disorder trial with an effective medication. In this study, the SOC category, Precontemplation (i.e., those subjects who reported the belief that they had no problem) were less likely to change compared to those who believed that they had a problem.
Levels of Motivation as Correlates of Librarians’ Task Performance in University Libraries In South – East, Nigeria

This paper is on levels of motivation as correlates of librarians’ task performance in university libraries in South – East, Nigeria. It is a corelational study. Questionnaire was used for data collection. Pearson Product Moment correlation Co-efficient and t-test of correlation were used for data analysis. The librarians in the university libraries studied are poorly motivated but greater majority of them perform moderately on their tasks in the libraries because of their interest and love in librarianship. The very low positive or no relationship existing between the librarians’ levels of motivation and their task performance is not significant. To get the best task performance out of all the librarians as some still need to be motivated, the university management should give all the librarians adequate motivation.
Diffraction Corrections to Fields Specularly Reflected by a Smooth 2-D Surface

Diffraction corrections to the geometric optics results were derived for a general case of specular reflection from a smooth, perfectly conducting 2-D body. The general equations are applied to the specific case when the surface directrix in the vicinity of the specular point can be approximated by the arc of the conic section curve (parabola, circle, ellipse, or hyperbola). These results extend upon the ones obtained earlier for backscattering only (I. M. Fuks, IEEE Trans. Antennas Propag., vol. 53, no. 5, pp. 1653-62, 2005) to the general case of bistatic scattering at arbitrary incidence angles
Multiregional Evaluation of the SimPlate Heterotrophic Plate Count Method Compared to the Standard Plate Count Agar Pour Plate Method in Water

ABSTRACT A new SimPlate heterotrophic plate count (HPC) method (IDEXX Laboratories, Westbrook, Maine) was compared with the pour plate method at 35°C for 48 h. Six laboratories tested a total of 632 water samples. The SimPlate HPC method was found to be equivalent to the pour plate method by regression analysis (r = 0.95;y = 0.99X + 0.06).