Miracle-dz/UniFAR-FTUs huggingface dataset:
Circular RNA hsa_circ_0001178 facilitates the invasion and metastasis of colorectal cancer through upregulating ZEB1 via sponging multiple miRNAs

Abstract Metastasis is the main cause of increasing cancer morbidity and mortality. However, the underlying mechanism of cancer metastasis remains largely unknown. In the present study, we identified one circular RNA (circRNA) closely related to the metastasis of colorectal cancer (CRC), namely hsa_circ_0001178. CRC patients with high hsa_circ_0001178 were more prone to have metastatic clinical features, advanced TNM stage and adverse prognosis. Stable knockdown of hsa_circ_0001178 significantly weakened CRC cell migratory and invasive capabilities in vitro as well as lung and liver metastases in vivo. Mechanistic study revealed that hsa_circ_0001178 acted as a competing endogenous RNA (ceRNA) for miR-382/587/616 to upregulate ZEB1 (a key trigger of epithelial-to-mesenchymal transition), thereby promoting CRC metastatic dissemination. Of note, ZEB1 could also increase hsa_circ_0001178 expression via physically binding to hsa_circ_0001178 promoter region. Collectively, our data uncover the crucial role of hsa_circ_0001178 in CRC metastasis, and targeted therapy based on this positive feedback ceRNA axis may be a promising treatment for metastatic CRC patients.
KNOWLEDGE OF DENTISTS ABOUT BIOSTATISTICS: A WORLDWIDE SURVEY

Background: The primary aim of our study, an international web-based survey, is to obtain (I-a) dentists’ statistical knowledge and (I-b) how this knowledge varies by their focus area (clinical vs. basic research). The secondary aim is to address the following questions: (II-a) to specify the point during dental education at which a biostatistics course should be taught and (II-b) to identify the key statistical methods relevant to dental education. Methods: A total of 252 dentists from 46 countries, who were invited to participate in our survey by e-mail, participated in our study. Dentists’ data were obtained via a web-based survey. The participants were chosen by screening dental journals. Results: The results indicate that while dental physicians place an emphasis on biostatistics education, the majority state that biostatistics education should be taken at the postgraduate level and few believe that it should occur during undergraduate education. Conclusions: In biostatistics education, the topic of sampling, which plays an important role at the planning stage of a study, should be given particular importance. Another relatively understudied topic that may be of great importance is non-parametric tests. Biostatistics education should also emphasize the notion that researchers should consult a biostatistician when planning research.
Life Events and Survival in Dementia: A 5-Year Follow-Up Study

Objectives: To examine the relationship between life events and survival for people with dementia. To investigate whether this relationship differs from that for people without dementia. To identify which psychiatric and social factors are associated with survival in people with dementia. Method: A prospective cohort study with external controls. One hundred and sixteen people with dementia and 50 fit, elderly controls were assessed for life events over a 6-month period. They were followed-up at 5 years and data collected on length of survival. Results: There was an association between two or more severe life events and reduced survival. This association appeared stronger for controls than people with dementia although the interaction was not significant (p = 0.052). The only psychiatric or social factor associated with poor survival in dementia was depression. Other factors associated with reduced survival in the dementia group were male sex, older age, poor physical health, later age of onset and a poorer level of functioning. Conclusions: This study provides some evidence that having two or more stressful and negative life events may reduce survival in older people with and without dementia. If replicated, this finding will have implications for our understanding of the clinical course of dementia.
Genital Chlamydia suis and C. trachomatis infections in pigs and optimization of C. trachomatis vaccine delivery

52 2.1. Chlamydia suis . 54 2.2. Infection experiment . 54 2.3. Chlamydial antigen detection . 55 2.4. Antibody responses . 55 2.5. Proliferative responses of PBMC and MC . 56 2.6. Flow cytometric analysis . 57 2.7. Cytokine secretion by PBMC and MC . 58 2.8. Histopathology . 58 2.9. Statistical analysis . 58 3.1. Macroscopic lesions . 59 3.2. Chlamydia suis vaginal excretion . 61 3.3. Chlamydial antigen detection in the urogenital tract . 62 3.4. Antibody responses . 63 3.5. Proliferative responses of PBMC and MC . 65 3.6. Immune cell populations . 66 3.7. Cytokine secretion by PBMC and MC . 68 3.8. Histopathology . 72 Acknowledgements . 77 8. Nucleic acid vaccination . 40
Ethnobotanical survey of the plants used in the treatment of diabetes.

The paper deals with the plant based folk practices used in the treatment of diabetes . The study was conducted in two districts of Kerala, a state rich in floral diversity. Even though modern medical facilities are available in these places, people in villages still use plant therapy to a considerable extent. This may be attributed to the rich floral wealth of the state, which makes the access to the medicinal plants comparatively easy, the lower cost factor, and to a popular belief that plant derived medicines are better suited for the body. The impact of modernization and commercialization of medical treatment has telling effect on the number of these users and so a proper documentation and preservation of these practices are essential.
Ahmed Glaucoma Valve Implantation Experience at King Hussein Medical Centre

Objectives: To evaluate Ahmed Glaucoma Valve Implantation at King Hussein Medical Center. Indications, outcomes, and complications were investigated. Methods: The medical records of all patients who had Ahmed Glaucoma Valve Implant surgery at King Hussein Medical Center during the period between August 2006 and January 2009 were retrospectively reviewed. A total of 50 cases were enrolled in this study. A specially designed medical record abstract form was used to collect the following data: type of glaucoma, visual acuity, intraocular pressure, number of medications, and postoperative complications. Simple descriptive statistics (frequency, mean, percentage) were used to describe the study variables Results: The mean age of patients was 54.3 ± 2.1 years (range 1.3 to 79.9 years). Types of glaucoma included uveitic glaucoma, paediatric glaucoma, aphakic/ pseudophakic glaucoma, neo-vascular glaucoma, traumatic glaucoma and previous failed trabeculectomy. The mean follow-up duration was 16.6 ± 1.7 months (range 9.8 months to 26.1 months). The mean intraocular pressure before surgery was 28.6 mm and 14.2 mmHg after surgery. The mean number of eye drops used by patient was 3.8 ± 0.4 (range 1 to 4) and 1.1 ± 0.2 (range 0 to 3) before and after surgery respectively. Transient postoperative hypotony with shallow anterior chamber occurred in 8 patients. Encapsulated bleb occurred in 5 patients. Revision of the procedure was performed in 3 cases. Endophthalmitis was not encountered in our series. Conclusion: Results of Ahmed Glaucoma Valve Implantation surgery at King Hussein Medical Center showed that it is safe and effective procedure for treating refractory glaucomas.
Natural Deaths in Custody: A 10 Year Mortality Study

Death in custody is usually associated with apprehension and community concern, and raises the suspicion of violation of human rights. Studies conducted in few countries have shown that people in custody have increased rate of morbidity and mortality than those not in custody. Many of these deaths are premature deaths and can be prevented with proper care and treatment. The present postmortem examination based retrospective study was undertaken to examine natural deaths in custody and provide mortality pattern in this population. A total 165 autopsies were performed during the 10 year period out of which 142 (86.06%) cases were of natural deaths. The study population consists of 138 (97.18%) males and 4 (2.81%) females and their age ranged from 21 to 78 years (mean age 46.80 years). It was noted that most common cause of death was diseases of the respiratory system (40.8%) followed by cardiovascular system (19.01%).
Negative Beliefs about Self and Illness: A Comparison of Individuals with Psychosis with or Without Comorbid Social Anxiety Disorder

Objective: This study set out to investigate whether socially anxious individuals with psychosis will perceive more loss, entrapment, shame and humiliation, will blame themselves more for their illness and have lower self-esteem than non-socially anxious individuals with psychosis. Method: Two groups of participants with psychosis with (n = 19) and without (n = 19) social anxiety disorder were matched on the basis of gender and diagnosis. Results: There were no differences between the two groups in terms of positive and negative symptoms. Participants with social anxiety had significantly higher levels of selfblame, entrapment, shame and lower self-esteem. Differences in entrapment, shame and self-esteem remained significant after controlling for depression. Conclusions: Negative beliefs about self and psychosis may be associated with the development of concurrent social anxiety disorder. The clinical and research implications of the findings are discussed.
Medical Home Finds Real Estate in a Children’s Hospital

The Center for children and youth with special health care needs (CYSHCN) at St. Christopher’s Hospital for Children in Philadelphia is one such model and has grown steadily over the last 10 years. The medical home model embraced by the Center for CYSHCN focuses on care coordination, patient- and family-centered care, and integrated communication tools (such as care plans and medical summaries). The vast majority of CYSHCN treated at the Center during this study ranged in age from 6 to 12 years. Of those children, 82% had public insurance, 17% required home-nursing services, 24% required mobility aids, and 16% required enteral nutritional/feeding tubes. The most common diagnoses included developmental delay, intellectual disability, and cerebral palsy. When compared with CYSHCN enrolled in a statewide medical home program, the severity of the medical conditions of CYSHCN cared for at the Center was statistically significantly higher/more complex.
Effective factors on the quality of clinical education from students and clinical instructors´s perspective of Gonabad nursing and midwifery faculty and its improvement solutions.

Identification and awareness of related factors in clinical education quality is the first scientific step for any action. The present research is to determine the effective factors in the quality of clinical education from students and clinical instructors´ perspective of Gonabad Nursing and Midwifery Faculty and its improvement solutions. Materials and Methods: In this cross-sectional and analytical study, 44 instructors of nursing and midwifery faculty and 92 final year students using census were studied. The research instrument consisted of two sections: demographic information and questions in five domains. Data were analyzed by statistical software SPSS version 21 and descriptive statistics (mean, standard deviation and relative frequency) and analytical (mean comparison tests). P<0.05 was considered significant. Results: According to the results of the study "clinical setting" with a frequency 8.72% was most significant. There was a significant relationship between students' gender, field of study and course of study (respectively P=0/04, P=0/004 and P=0/000). Conclusion: According to the results, the most effective field is clinical setting. So it is important to pay attention to education managers and planners to improve the quality of clinical education.
Risk Factors for Cardiovascular Disease in Infertile women with Polycystic Ovarian Syndrome

A study was conducted to evaluate the risk of cardiovascular disease (CVD) in infertile women with polycystic ovary disease. There were 46 test subjects in the age group of 20 to 40 years and 40 age matched healthy controls. Serum lipid profile, fasting blood sugar (FBS) and reproductive hormones namely Leutinizing hormone (LH), follicle stimulating hormone (FSH), Prolactin and Estradiol were estimated in this era of all the subjects after obtaining their informed consent. Cytoklinesis-block micronuclei (CBMN) was also evaluated and attempts were made to correlate the findings with the risk of CVD. Decreased HDL and elevated levels of all other biochemical and endocrinological parameters were observed in the test subjects. A significantly elevated level of micronuclei (MN) in the test subject along with the above parameters and body mass index (BMI) is suggestive of increased risk of CVD in PCOS.
Prevalence of Dissociative Symptoms and Disorders in an Adult Psychiatric Inpatient Population in Canada

Objective: This study attemptedto estimate theprevalence ofdissociative symptoms and disorders in a Canadian adult psychiatric inpatient population and also attempted to determine the extent to which dissociative disorders were recognized by the attending clinical staff Method: All appropriate and consenting adultpsychiatric inpatientsat the Kingston Psychiatric Hospital in Kingston, Ontario, were given the Dissociative Experiences Scale. Patients scoring 25 or greater were interviewed with the Dissociative Disorders Interview Schedule and the Structured Clinical Interviewfor DSM-IV Dissociative Disorders. Admission or discharge diagnoses data were used to determine whether or not dissociative disorders 'were being recognized. Results: A total of48patients completed the Dissociative Experiences Scale and 14 (29%) scored 25 or greater. The prevalence of dissociative disorders in this hospital population was estimatedto be 17%. Dissociative identity disorder wasfound in six percent, dissociative amnesia in eight percent and dissociative disorder not otherwise specified in two percent of the population. These disorders tended to be under-recognized. Conclusion: Research on more extensive populations is required to establish the true prevalence of dissociative symptoms and disorders in psychiatric inpatients.
Laparoscopic Anti-Reflux Surgery Promotes Regression or Disappearance of Barrett's Esophagus, but does not Eliminate the Risk of Esophageal Adenocarcinoma Cirurgia Anti-Refluxo Promove a Regressão ou Desaparecimento do Esôfago de Barrett, mas não Elimina o Risco de Adenocarcinoma de Esôfago

Background: Barrett’s Esophagus (BE) is a complication of gastroesophageal reflux disease (GERD) and can be a premalignant condition. Nevertheless, there is no consensus about the effectiveness of surgery in preventing malignant transformation in patients with BE. The impact of Laparoscopic Anti-Reflux Surgery (LARS) on those suffering from BE is still not understood. The objective of this study is to prospectively evaluate clinical, endoscopic and histopathological results after LARS in patients with BE. Methods: 372 patients suffering from GERD underwent Laparoscopic Nissen Fundoplication (LapNissen). Among them, 95 (25.5%) presented BE. Follow-up using endoscopic biopsy was performed in all patients. The average follow-up was 59.8 months. Results: The control of symptoms was effective in 92 patients. Three patients remained symptomatic, and BE remained unaltered in these patients. Regression of BE occurred in 58 patients (63.9%). Of these, 26 (28.9%) showed no further signs of BE in endoscopic or histopathological examinations. In one patient, who remained asymptomatic after surgery, the degree of dysplasia increased to high-grade dysplasia, and another asymptomatic patient developed adenocarcinoma. Both underwent endoscopic mucosectomy of the BE area. Conclusions: LapNissen is safe and effective in the control of symptoms in a significant number of patients with BE. In spite of the control of GERD attained by most patients and regression occurring in a high percentage of the patients who underwent LARS, the development of high-grade dysplasia and adenocarcinoma is not fully prevented by anti-reflux surgery. Routine endoscopy follow-up with biopsy is recommended for all patients with BE after LARS.
NURSES' PERCEPTIONS OF SUPPORT IN CARING FOR PEOPLE LIVING WITH HIV AND AIDS (PLWHA) IN VHEMBE DISTRICT, LIMPOPO PROVINCE

The purpose of this study was to explore and describe experiences of nurses regarding social support in caring for people living with HIV and AIDS (PLWHA) in Vhembe district, Limpopo Province. A qualitative research design which was exploratory, descriptive and contextual was used, with a purposive and theoretical sample of nurses who provided care in a regional hospital in Vhembe district of Limpopo Province. Data saturation occurred after indepth interviews with fifteen participants, field notes were also used during data collection. The findings revealed that nurses caring for PLWHA experienced lack of social support from colleagues and managers and needed to be assisted to cope with care. Recommendations that are described focused on supporting nurses to cope in caring through provision of work-based support programmes.
ASSESSMENT OF QTC INTERVAL: A CARDIOVASCULAR RISK FACTOR IN ASYMPTOMATIC TYPE- II DIABETICS

Background and Objectives: Diabetes Mellitus (DM), metabolic disorder, characterized by hyperglycaemia. There are two main types of diabetes mellitus. Insulin dependent diabetes mellitus (type I DM), Non insulin dependent diabetes mellitus (type II DM). The WHO reports show that 32 million Indian had diabetes mellitus in the year 2000 and the international diabetic federation estimates the number is further set to raise to 69.9 million by 2025 and 80 million by 2030. It is associated with marked increased risk of cardiovascular diseases (CVD), Electrocardiographic (ECG) abnormalities are found to be predictors of silent ischemia in asymptomatic persons. QT C interval measures the duration of electrical activation and recovery of the ventricular myocardium and varies inversely with the cardiac rate. Methods: The study was conducted in department of Physiology, J.J.M Medical College, Davangere, from May 2011 to May 2012. Detailed physical and systemic examination of selected subjects was done. The instrument used to record electrocardiogram is the twelve channels Electrocardiograph. Results: A total of 100 subjects with fifty diagnosed type II DM cases & 50 age and sex matched controls participated in this study. The mean QT interval values (in sec) were 0.40 ± 0.04 and 0.38 ± 0.06 among type II DM cases. There was statistically highly significant increased in QT internal among type II diabetics, mean QT C interval (in sec) was 0.43 ± 0.04 and 0.40 ± 0.06 among Type II DM cases and controls respectively. QT C showed statistically significant increase in type II Diabetics when compared to controls (P<0.05). Interpretation and Conclusion: ECG alterations help to evaluate and detect the sings of myocardial ischemia even in asymptomatic patients, most frequent ECG abnormality in type II diabetic are prolonged QT & QTc intervals. This was a sensitive sign of neuropathy; diagnose CAN, left ventricular hypertrophy due to blood pressure and sudden death. Early detection of QTC will be a good indicator in decreasing the incidence of sudden death due to cardiovascular diseases in diabetics. Key words: type- II diabetics, T2 DM, CAN, QTc, QT, sudden death.
Obsessional Neurosis*

SYNOPSIS Major differences in personality structure between obsessional neurotics and their relatives are against the hypothesis that there is a strong genetic component in obsessional states. Analysis of symptom patterns contradict a major role for aggression, either overt or controlled, in this condition. Anxiety of endogenous origin is seen as the major basic cause and obsessional symptoms act as defences against mounting pathological anxiety. This process needs to he studied more closely if rational treatment is to eventuate.
Childhood Maltreatment and Aggressive Behaviour in Violent Offenders with Psychopathy

Objective: To document experiences of childhood maltreatment among violent offenders with antisocial personality disorder (ASPD) distinguishing between those with and without the syndrome of psychopathy (+P and -P), and to determine whether maltreatment is associated with proactive and reactive aggression. Method: The sample included 10 violent offenders with ASPD+P, 15 violent offenders with ASPD+P, and 15 nonoffenders. All participants completed interviews with the same forensic psychiatrist focusing on physical, sexual, and emotional abuse prior to age 18 using the Early Trauma Inventory. Aggression was assessed using the Reactive-Proactive Questionnaire. Results: Violent offenders with ASPD+P reported significantly more severe childhood physical abuse, but not more sexual or emotional abuse, than violent offenders with ASPD-P and nonoffenders. Psychopathy Checklist'Revised (PCL-R) scores, but not childhood physical abuse, were associated with proactive aggression. Childhood physical abuse was associated with reactive aggression, as was an interaction term indicating that when both PCL-R scores and childhood physical abuse were high, so was reactive aggression. Conclusions: Among violent offenders, PCL-R scores were positively associated with proactive aggression, while experiences of childhood maltreatment were not. This finding concurs with previous studies of children and adults and suggests that proactive aggression may be a behavioural marker of psychopathic traits. By contrast, childhood physical abuse was associated with reactive aggression, even among violent offenders with high PCL-R scores. This latter finding suggests a strong influence of childhood physical abuse on the development of reactive aggression that persists over the lifespan.
Insight in psychiatry

Preface Part I. Historical and Clinical: 1. Historical overview 2. The psychological perspective: gestalt, cognitive and psychoanalytic 3. Insight in clinical psychiatry: empirical studies 4. Insight in organic brain syndromes Section 1: Insight into neurological states 5. Insight in organic brain syndromes Section 2: Insight into dementia Part II. Conceptual: 6. The conceptualisation of insight 7. The relational aspects of insight: the 'object' of insight assessment 8. Towards a structure of insight Section 1: Awareness and insight: an essential distinction? 9. Towards a structure of insight Section 2: The relationship between awareness and insight Index.
College Students Who Are Deafblind: Perceptions of Adjustment and Academic Supports

This descriptive qualitative interview study investigates the perspectives of college students who are deafblind. The purpose of the research was to investigate participants’ perceptions about being college students and deafblind and to gain insights into their experiences. Qualitative methods were used to conduct videotaped interviews with 11 students. Interviews were transcribed and analyzed. Results of the study indicate that students had to manage both adjustments to visual impairment and academic supports. Implications for practice include being knowledgeable about deafblindness and supporting selfdetermination skills.
General Rules

The Association would like to use this space to publicly re-affirm its commitment and dedication to these shows of the National Junior Angus Association. Junior Angus shows are primarily held to foster the interests of the participating junior members in the Angus breed as well as to provide them with a special, hands-on opportunity to breed, raise and show Angus cattle. The intended emphasis in the junior shows has always been on competition among peers as well as the development of leadership skills, decision-making skills and a sense of responsibility.