Miracle-dz/UniFAR-FTUs huggingface dataset:
An Examination of the Pediatrician-Prescribed Gaming App-Based Exercise Prescription: A Pilot Study.

This study examined the effectiveness of a physical activity (PA) intervention among obese Hispanic children delivered by a free mobile phone game application (app) recommended by a pediatrician. A sample of 40 (age M=10.16[2.01] years) children participated in this pilot study. Preand posttest data were collected on participants’ PA attitudes, intention, and objectively measured PA. The intervention was a game-based exercise prescription to engage in at least 20 minutes daily for seven days in moderate-to-vigorous PA (MVPA) delivered by their primary care pediatrician. The results showed a statistically significant decrease in sedentary time (SED) (t(26)=3.03, p=. 007, d=. 66) and an increase in moderate PA (MPA) (t(26)=3.19, p=. 005, d=-. 69), vigorous PA (VPA) (t(26)=-5.74, p<. 001, d=-1.25), and MVPA (t(26)=-9.09, p<. 001, d=-1.89). In addition, the study showed increase in PA attitudes (t(26)=-3.63, p<. 001, d=-1.10) and PA intention (t(20)=-3.13, p=. 001, d=-. 94) after the intervention. This study provides evidence that a mobile app gaming-based exercise prescription may help to engage obese Hispanic children in health enhancing PA.
The Effects of Soil pH and Texture on the Molting Success and Survival of Blacklegged Ticks (Ixodes scapularis): A Field Experiment

iii Chapter 1: The Effects of pH and Texture on Tick Molting and Survival Introduction. 1 Methods. 5 Results. 9 Discussion. 11 References. 16 Chapter 2: Tick Densities and Host Body Burdens Introduction. 19 Methods. 23 Results. 24 Discussion. 26 References. 28 Appendix. 31
Effectiveness of treatments for firework fears in dogs

An online questionnaire survey investigated (1) management and (2) treatment methods for firework fears in dogs employed by dog owners and their (perceived) effectiveness. A PCA on data from 1225 respondents revealed four management strategies (i.e. interventions during firework exposure): the principal components “Environmental modification” (e.g. providing a hiding place, keeping windows and blinds closed, and playing music), “Feed/Play” (providing the dog with chews, play and food during fireworks in general, as well as contingent on loud bangs), “Alternative” (use of calming neutraceuticals, pheromones, herbal products, homeopathic products, Bach flowers, and essential oils) and “Interaction” (allowing body contact, petting and talking to the dog when loud bangs occurred). To explore possible effects of these management methods on fear development, the components were correlated with a score for fear progression. Of the four components, only “Feed/Play” was statistically associated with an improvement in fear responses to fireworks. To evaluate the effectiveness of various treatment strategies, owners were asked to select from a range of options which interventions they had used and whether they considered them as effective. With prescription medication (N=202), improvements were noted by 70% of owners. While individual products were not evaluated, the reported success rates for the categories “pheromones” (N=316), “herbal products” (N=282), “neutraceuticals” (N=211), “essential oils” (N=183), “homeopathic remedies” (N=250) and “Bach flowers” (N=281) were all in the range of 27-35%, which is not higher than would be expected based on a placebo effect. 44% of respondents (N=300) deemed pressure vests as effective. Counterconditioning (providing desirable stimuli after the occurrence of noises) was the most successful training technique according to the owners (N=694), with a reported effectiveness of over 70%. Relaxation training (N=433) was reported to be almost as successful at 69%, while noise CDs (N=377) were effective in 55% of cases. Thus, counterconditioining, relaxation training and psychoactive medication appear to be the most effective strategies in the treatment of firework fears in dogs. On this basis it is recommended that ad-hoc counterconditioning and relaxation training should complement the standard behavioral technique of desensitization/ counterconditioning with noise recordings. Highlights An online survey on treatment options for firework fears in dogs was performed Feeding or playing with dogs during fireworks was associated with fear improvement Success was highest for ad-hoc counterconditioning, relaxation training and medication Success was similar for pheromones, neutraceuticals and other alternative products Success rates for these alternative products are consistent with a placebo effect
Compact Modeling of Single-Event Latchup of Integrated CMOS Circuit

This paper presents a compact model of latchup considering design and process dependence. The new approach is more realistic and inspirited from the classical model. This model was used to confirm the single-event latchup (SEL) robustness of D-flip-flops (DFFs) used in Readout Circuit of Infrared-sensors developed by Sofradir. SEL cross sections are presented by the mean of the Monte Carlo tool MUSCA SEP3 in order to validate the new latchup modeling approach.
Absence of an Immunodominant MHC Class Ia-Restricted Epitope Elicits a Compensatory MHC Class Ib-Restricted CD8+ T Cell Response to Mouse Polyomavirus CNS Infection

CD8 T lymphocytes are the major immunocytes responsible for host defense against viral infection. The ligand for a CD8 T cell receptor consists of a short peptide derived from a viral protein bound to a heterodimeric molecule encoded within the major histocompatibility complex (MHC). Most MHC molecules are highly polymorphic, a property responsible for the extensive repertoire of peptides available for recognition by T cells; these MHC molecules are designated MHC-Ia. Given the dynamic interplay between a host’s immune system and viruses, viruses often mutate antigenic peptides to prevent binding to MHC-Ia molecules and thereby evade recognition by antiviral CD8 T cells. Recently, nonand oligo-morphic MHC-Ib molecules have been described as adept presenters of microbial peptides to CD8 T cells across most outbred members of a given species. Our group recently uncovered a protective MHC-Ib-restricted CD8 T cell response to mouse polyomavirus (MuPyV), a natural, persistent mouse pathogen; however, this response was only detected in mice lacking MHC-Ia molecules. In this study, we asked whether ablation of the dominant MHC-Ia-restricted viral peptide epitope in MuPyV-infected immunocompetent mice would allow emergence of CD8 T cells specific for a minor MuPyV capsid protein derived epitope, Q9:VP2.139-147. This restriction element is part of the MHC-Ib family and is shared across inbred mouse strains with varying MHC-Ia alleles. To test the proposed hypothesis, we inoculated C57BL/6 mice intracerebrally (i.c.) with a mutant MuPyV lacking the dominant CD8 T cell epitope D:LT359. The i.c. route of inoculation causes robust recruitment of anti-MuPyV T cells to the brain, an organ targeted by the human JC polyomavirus to cause the often-fatal demyelinating disease, progressive multifocal leukoencephalopathy. Using this LT359 mutant virus and assessing T cell responses by intracellular cytokine staining (ICS), we uncovered a strong MHC-Ib-restricted CD8 T cell response to the Q9:VP2.139 epitope. Notably, VP2.139 CD8 T cells were observed in the infected brain, but not the spleen, although virus
ANALISIS PENERAPAN PENDEKATAN SAINTIFIK TERHADAP DALAM PEMBELAJARAN BERDASARKAN KURIKULUM 2013

Perubahan kurikulum mengakibatkan perubahan pada pelaksanaan pembelajaran. Guru wajib melaksanakan pembelajaran sesuai dengan kurikulum. Penelitian ini bertujuan untuk untuk mendeskripsikan penerapan pendekatan saintifik dalam pembelajaran berdasarkan kurikulum 2013 tema 9 (makananku sehat dan bergizi) kelas IV semester genap SD No. 4 Banyuasri tahun pelajaran 2014/2015. Jenis penelitian ini termasuk penelitian deskriptif. Metode yang digunakan yakni metode kulaitatif. Subjek penelitian ini adalah guru kelas dan siswa kelas IV di SD No. 4 Banyuasri. Data dikumpulkan dengan metode observasi, wawancara, kuesioner, dan dokumentasi. Analisis data dilakukan sebelum dan selama,dan sesudah melakukan pengumpulan data di lapangan. Hasil penelitian menunjukkan kemampuan guru mengajar berada pada persentase 90.41% hal tersebut menunjukkan guru sudah melaksanakan pembelajaran dengan sangat efektif. Penerapan pendekatan saintifik dalam pembelajaran berdasarkan kurikulum 2013 mengalami kendala seperti kendalanya dalam menyesuaikan kesediaan materi, dengan alokasi waktu yang ada, namun hal tersebut bisa diatasi oleh guru dengan upaya mencari atau menambah informasi dari berbagai sumber. Informasi baik melalui media cetak/media sosial dan internet juga dengan mengadakan diskusi dengan rekan guru atau teman kerja. Berdasarkan pandangan siswa terhadap penerapan pendekatan saintifik dalam pembelajaran berdasarkan kurikulum 2013 hasil yang diperoleh adalah sebesar 71.77%, hal ini menunjukan pembelajaran pendekatan saintifik cukup efektif. Dalam hal ini penerapan pendekatan saintifik dalam pembelajaran berdasarkan kurikulim 2013 udah berhasil diterapkan di Sekolah Dasar. Kata Kunci : analisis, pendekatan saintifik, tema 9 This research aimed to describe the application of a scientific approach to learning based curriculum 2013 theme 9 (my food is healthy and nutritious) class IV even semester SD No. 4 Banyuasri school year 2014/2015. This type of research include descriptive studies. The method used the qualitative method. The subjects were teachers and students of the fourth grade class at Elementary No. 4 Banyuasri. Data collected by observation, interviews, questionnaires, and documentation. Data analysis was performed before and during, and after data collection in the field. The results showed the results of a check list for 90.41% of teachers already implementing learning very effectively, based on interviews but there are some obstacles can be overcome by the teacher, based on questionnaires given to students results obtained by 71.77%, this shows quite a scientific approach to learning effective and based on the documentation, study conducted by the RPP made by the class teacher is appropriate. In this case the application of a scientific approach to learning based curriculum 2013 already successfully applied in primary school. keyword : analytical, scientific approach, theme 9
Economic and Technical Evaluation of Flexible Power Generation Scenarios for a Biogas Plant

Biogas plants can contribute significantly to the integration of renewable energy sources in the energy system due to their flexible operability. The storability of the energy carrier enables them to generate power in a demand-oriented way and to participate in electricity markets that focus on balancing power supply and demand. In this study process simulation was used to investigate the economic and technical effects of flexible power generation on an Austrian biogas plant that focuses on biomethane production. Three different power generation scenarios were evaluated considering participation in the electricity spot market and markets for control energy reserves, while continuously producing biomethane. The results show that no major technical adaptions are needed for flexible power generation but an appropriate support scheme (premium system) is required to make demand-oriented power generation economically viable. The determined required premium was 37.3-99.9 EUR/MWh depending on the power generation scenario.
Identification of Two Independent COL5A1 Variants in Dogs with Ehlers–Danlos Syndrome

BACKGROUND The Ehlers Danlos syndromes (EDS) are a heterogeneous group of heritable disorders affecting connective tissues. The mutations causing the various forms of EDS in humans are well characterized, but the genetic mutations causing EDS-like clinical pathology in dogs are not known, thus hampering accurate clinical diagnosis. RESULTS Clinical analysis of two independent cases of skin hyperextensibility and fragility, one with pronounced joint hypermobility was suggestive of EDS. Whole genome sequencing revealed de novo mutations of COL5A1 in both cases, confirming the diagnosis of the classical form of EDS. The heterozygous COL5A1 p.Gly1013ValfsTer260 mutation characterized in case 1 introduced a premature termination codon and would be expected to result in α1(V) mRNA nonsense-mediated mRNA decay and collagen V haploinsufficiency. While mRNA was not available from this dog, biochemical analysis of the dermis suggested reduced collagen V in the dermis and ultrastructural analysis demonstrated variability in collagen fibril diameter and the presence of collagen aggregates, termed ‘collagen cauliflowers’, consistent with COL5A1 mutations underlying classical EDS. In the second case DNA sequencing demonstrated a p.Gly1571Arg missense variant in the COL5A1 gene. While samples were not available for further analysis, such a glycine substitution would be expected to destabilize the strict molecular structure of the collagen V triple helix and thus affect protein stability and/or integration of the mutant collagen into the collagen V/collagen I heterotypic dermal fibrils. CONCLUSIONS This is the first report of genetic variants in the COL5A1 gene causing the clinical presentation of EDS in dogs. These data provide further evidence of the important role of collagen V in dermal collagen fibrillogenesis. Importantly from the clinical perspective we show the utility of DNA sequencing, combined with the established clinical criteria, in the accurate diagnosis of EDS in dogs.
Chemical composition of Citrus limon (L.) Osbeck growing in southwestern Nigeria: Essential oil chemo types of both peel and leaf of lemon

The leaf and peel essential oils of Citrus limon, collected from the Agboku area of Ado-Odo Local government Area in Ogun state, Nigeria, were obtained by hydro distillation and analysed by GC-FID and GC-MS. The leaf oil was rich in limonene (31.5%), sabinene (15.9%), citronellal (11.6%), linalool (4.6%), neral (4.5%), and geranial (4.5%), while the peel essential oil was dominated by limonene (85.9%). A numerical cluster analysis of leaf and peel essential oils reported in the literature revealed three identifiable clusters of peel oil (a limonene chemotype and two mixed chemotypes, limonene/citral/β-pinene and limonene/linalool/linalyl acetate). The leaf essential oils fell into four clusters (limonene/citral/β-pinene, β-pinene/γ-terpenene, limonene/sabinene, and linalool/linalyl acetate). The leaf and peel essential oils from Agboku, Nigeria occupied the limonene/sabinene and the limonene chemotypes, respectively.
Transport of bivalve larvae in the James River, Virginia

For nearly 100 years, the James River has been the primary source of seed oysters for Virginia. A disease caused by Minchinia nelsoni (MSX) killed most oysters in high-salinity waters in the lower river in 1959 and 1960, and planting has not been resumed in these areas (Andrews 1983). Large populations of oysters on Hampton Bar and near the mouth of the river which served as broodstocks were destroyed. After 1960, setting declined drastically in regularity and intensity to about one tenth of that which occurred in the 1950's. Setting patterns suggest two types of seed areas in Chesapeake Bay: (1) high freshwater discharge, open or flushing estuaries with light spatfalls that decrease in intensity with distance from the river mouth; the James River is a typical example; and (2) low discharge, trap-type estuaries where intensive sets are heaviest near the head of the saline sector; examples are the Piankatank and Great Wicomico rivers in Virginia. Larval transport systems in the two estuarine types differ in quantity of larvae retained and regularity of spatfalls. Hourly plankton samples in the James River during 10 days in 1964 and 1965 revealed regular cyclic abundance of larvae with tidal stages. Larvae were 5 to 10 times more numerous during high-tide periods than at low-tide periods. Mostly early-stage larvae were distributed randomly throughout vertical columns of water. Larvae of other bivalve species exhibited similar distributions and fluctuations in abundance with tidal stages. Patterns of larval distribution were similar for all depths at five stations, both in the channel and over oyster beds, during 16 tidal cycles in 1965. Frequent recruitment of new larval broods and disappearance of most oyster larvae before ages of 3 to 5 days suggest losses due to physical dispersion and predation. Only when larvae reached advanced umbo stages did they actively select deeper water strata in the channel which provided a transport system to carry them upriver. In the 1950's, spatfall occurred every week in the James River from 1 July to 1 October each year; since 1960, light, erratic setting has prevailed every year. If one assumes that predation, larval ecology, and physical transport systems have not changed, it appears that broodstocks have become inadequate, or that larvae were killed by toxic substances.
The gut microbiota of the blattid cockroach Shelfordella lateralis

15 Introduction 16 Materials and Methods 17 Results 21 Discussion 33 References 38 3 The response of gut microbiota of the cockroach Shelfordella lateralis to changes in diet 44 Abstract 44 Introduction 45 Material and Methods 46 Results 48 Discussion 53 References 5744 Introduction 45 Material and Methods 46 Results 48 Discussion 53 References 57 4 Individual variation in methanogenesis is not linked to archaeal composition within the colon of the blattid cockroach Shelfordella lateralis 60 Abstract 60 Introduction 61 Material and methods 64 Results 67 Discussion 73 References 7660 Introduction 61 Material and methods 64 Results 67 Discussion 73 References 76
Citizen Perceptions of E-Government in the Kurdistan Region of Iraq

Despite increasing investment by governments globally, citizens in some countries are less willing to engage with e-government innovations. While previous studies have examined what might encourage citizens to adopt e-government services more broadly, further research is required to understand those factors that impede or enable e government adoption in countries that have, or are in the process of, transitioning to democratic self-rule. This study is the first to investigate citizen attitudes to e-government adoption in the Kurdistan Region of Iraq and thus provides insight into the factors affecting the adoption of e-government within an emerging democratic state. This study also distinguishes between two types of e-government services; informational and transactional. Thus a research model with two elements is developed and tested; one for intention to use informational e government and one for intention to use transactional e-government. Data were collected through a survey administered to university students and non-academic employees in Arbil the capital city of Kurdistan, and analysed using structural equation modelling. Perceived usefulness, social influence, trust in government and perceived risk were found to be significantly and directly associated with the intention to use both kinds of e-government services. However perceptions of ease of use, information quality and trust in the Internet were not significant.
1222-P: Comparative Efficacy of Ertugliflozin (ERTU) vs. Other Sodium-Glucose Cotransporter 2 Inhibitors (SGLT2i): Model-Based Meta-analysis (MBMA) of HbA1c Lowering

Background: ERTU is a selective sodium-glucose cotransporter 2 (SGLT2) inhibitor approved for the treatment of adults with type 2 diabetes mellitus (T2DM). As several SGLT2i are commercially available, MBMA of the HbA1c-lowering effect of these drugs was undertaken to assess their comparative effectiveness. Methods: MBMA quantified the time course of dose vs. HbA1c response of SGLT2i and evaluated the impact of covariates including baseline HbA1c, estimated glomerular filtration rate (eGFR) and background diabetes treatment on HbA1c efficacy. Of the 496 randomized controlled trials (RCTs) in the database, 94 RCTs representing >31,000 T2DM patients were with SGLT2i, including 5 RCTs for ERTU. Results: For SGLT2i, there was a 28.7% (95% CI, 24.5 to 33.1%) greater relative HbA1c efficacy for a 1% absolute increase in baseline HbA1c. Additionally, the HbA1c efficacy was 25.0% (17.0 to 34.0%) greater on a diet background alone relative to a background of metformin (or other oral antidiabetic treatment). For every 10 mL/min/1.73m2 decrease in eGFR, there was a 8.80% (5.90 to 11.6%) decrease in HbA1c efficacy. Conclusion: This MBMA allowed an indirect comparison of SGLT2 inhibitor efficacy across trials (Table). Overall, ERTU doses of 5 and 15 mg were of comparable or numerically greater efficacy to other SGLT2i. Disclosure D. Fediuk: Employee; Self; Pfizer Inc. J. Mandema: Consultant; Self; Merck & Co., Inc., Pfizer Inc., Sanofi. K. Sweeney: Employee; Self; Pfizer Inc. S.G. Terra: Employee; Self; Pfizer Inc. V. Sahasrabudhe: Employee; Self; Pfizer Inc. Funding Pfizer Inc.; Merck Sharp & Dohme Corp.
Supplementation strategies and their effects on ewes colostrum and milk compositions in the initial third lactation period

The objective of this study was to analyze colostrum and milk compositions of ewes kept in pasture receiving different types/levels of supplementation and to analyze milk composition variation throughout the initial third lactation period. After confirmation of pregnancy, 54 ewes were kept in pasture and supplemented from the final third of gestation until weaning with multiple mixture or concentrate (0.4% or 0.8% of body weight). Milk collections were carried out in the postpartum period to collect colostrum (day 0), and on the seventh, 14th, 21st and 28th milking days. Samples were obtained by manual milking and analyzed for protein, fat, casein, lactose, total solids and defatted dry extract. No effects from the different types of supplementation were observed on the colostrum composition or in relation to milk composition. An effect of supplementation was only found for lactose contents, which were higher for animals that consumed a higher level of supplementation. In relation to the milking days, a linear decrease in protein, casein, total solids and defatted dry extract contents was observed between the seventh and the 28th day of lactation. No interaction between type of supplementation and the milking days was observed. The different types of supplementation did not alter the colostrum composition of Santa Inês crossbred ewes, however they had an influence on milk composition. Protein, casein, total solids and defatted dry extract decrease linearly between the seventh and the 28th day of lactation.
Slightly frequency-shifted reference ultra-wideband (UWB) radio: TR-UWB without the delay element

Recently, there has been significant interest in ultra-wideband (UWB) radio techniques. A promising UWB technique being widely considered for low data rate applications, such as those often encountered in sensor networks is the transmitted reference (TR) UWB scheme. However, the standard TR-UWB scheme, while often motivated by the simplicity of its receiver is still dogged by implementation concerns. In particular, the receiver requires an extremely wideband delay element, which is difficult to incorporate into low-power integrated systems. In this paper, a transmitted-reference scheme is proposed in which the separation between the data and reference signals, rather than being a time delay, is a slow rotation over the symbol interval. This provides a (slightly) frequency-shifted reference that, while orthogonal to the data-bearing pulse, still goes through a nearly equal channel. A detailed analysis of the proposed scheme is provided, and numerical results demonstrate that the proposed system not only achieves the primary goal of providing a much simpler receiver architecture, but also that it outperforms the standard TR-UWB system.