Miracle-dz/UniFAR-FTUs huggingface dataset:
Influence of Well-Being Indices and Recovery State on the Technical and Physiological Aspects of Play During Small-Sided Games

Abstract Selmi, O, Gonçalves, B, Levitt, DE, Ouergui, I, Sampaio, J, and Bouassida, A. Influence of well-being indices and recovery state on the technical and physiological aspects of play during small-sided games. J Strength Cond Res 35(10): 2802–2809, 2021—Soccer players performing at high level are frequently exposed to periods of intense training, which can induce substantial stress and fatigue. These high-intensity stimuli likely lead to a lower state of well-being and poor recovery and, consequently, may affect players' performance. This study aimed to assess the influence of well-being indices (i.e., self-ratings of sleep, stress, fatigue, and delayed onset muscle soreness [DOMS]) and the total quality of recovery (TQR) on technical and physiological measures during soccer small-sided games (SSGs). Twenty male professional soccer players (age: 25.1 ± 1.0 years) performed four 25-minute SSG sessions. Well-being indices were collected before each SSG-session. Heart rate was continuously measured throughout each session, and the ratings of perceived exertion and blood lactate concentration were collected after each SSG. A hierarchical cluster analysis was performed across variables and cases to identify associations between variables and variability in players' responses between sessions. No significant correlations were found between well-being indices, TQR and physiological parameters. Total quality recovery was positively correlated with successful pass % (r = 0.27) and interceptions (r = 0.25) and negatively correlated with lost balls (r = −0.25). Fatigue and DOMS were negatively correlated with tackles (r = −0.29, r = −0.28, respectively), successful pass % (r = −0.58, r = −0.55, respectively) and interceptions (r = −0.25, r = −0.27, respectively), and positively correlated with lost balls (r = 0.32, r = 0.28, respectively). Results provide an alternative and complementary method to understand training responses and can be an objective tool to help create subgroups in training for optimizing performance. This study demonstrates the efficacy and utility of using simple well-being and recovery measures to help coaches monitor athlete readiness.
Cognitive and Academic Outcomes Following Childhood Cortical Stroke

The majority of pediatric neuropsychological stroke research has focused on perinatal stroke outcomes given its relative frequency. Meanwhile, childhood-onset stroke is under-represented in the literature, resulting in limited knowledge about its neurocognitive sequelae. This retrospective study examined cognitive outcomes in children and youth (n = 27) with childhood arterial ischemic stroke (stroke occurring between 29 days and 18 years of life) isolated to the cortical region. Intellectual, academic, language, visual-perception, visual-motor integration, fine motor coordination, and executive function scores were examined relative to normative means. Results indicate that although these children are doing well in terms of general intellectual ability, they demonstrate lower scores on tasks of processing speed and fine motor coordination. Exploratory analysis also revealed that of the personal and neurologic factors examined, age at stroke was positively correlated with perceptual reasoning and fine motor control, age at assessment was negatively correlated with math calculation abilities, and maternal education was positively correlated with working memory and parent-reported behavioral regulation and impulse inhibition abilities. While neurologic variables were not predictive of cognitive neuropsychological outcomes, those with significant poorer performance had higher rates of medium/large, right-sided lesions with frontal lobe involvement. Our results highlight the overall resilience of the injured developing brain but also the vulnerability of specific cognitive skills within this unique population.
Asynchronous Control of ERP-Based BCI Spellers Using Steady-State Visual Evoked Potentials Elicited by Peripheral Stimuli

Brain-computer interface (BCI) spellers based on event related potentials (ERPs) are intrinsically synchronous systems. Therefore, selections are constantly made, even when users are not paying attention to the stimuli. This poses a major limitation in real-life applications, in which an asynchronous control is required. The aim of this study is to design, develop and test a novel method to discriminate whether the user is controlling the system (i.e., control state) or is engaged in other task (i.e., non-control state). To achieve such an asynchronous control, our method detects the steady-state visual evoked potentials (SSVEPs) elicited by peripheral stimuli of ERP-based spellers. A characterization experiment was conducted with 5 subjects to investigate general aspects of this phenomenon. Then, the proposed method was validated with 15 subjects in offline and online sessions. Results show that the proposed method provides a reliable asynchronous control, achieving an average accuracy of 95.5% for control state detection during the online sessions. Furthermore, our approach is independent of the ERP classification stage, and to the best of our knowledge, is the first procedure that does not need to extend the duration of the calibration sessions to acquire non-control observations.
Applicant Faking of Personality Inventories in College Admission: Applicants’ Shift From Honest Responses Is Unsystematic and Related to the Perceived Relevance for the Profession

Abstract This study aims to further our understanding of applicant faking twofold. First, it challenges viewing applicant faking as a systematic shift from otherwise honest responses. To this end, systematic item parameter shifts are proposed and tested across applicants and incumbents. Second, items’ perceived relevance in a college admission process as real-life selection is scrutinized: Are applicants influenced by items’ perceived relevance for the education, the prospective profession, or both? Participants (n = 840) filled out a Big Five inventory in a college admission process, and were retested 10 months later under standard instructions. Furthermore, they rated items’ perceived relevancies for educational and professional purposes. Linear partial credit models were used to model item parameter shifts across response conditions. All proposed patterns of systematic shifts fit the data worse than unsystematic shifts. Unsystematic shifts were greater for lower response categories and items that were perceived as more relevant for the profession. The perceived relevance for education moderated the latter effect. Taken together, applicant faking should not be understood as applicants systematically shifting from their otherwise honest responses. Although applicants elevate their responses, it is not in a systematic way. Furthermore, determinants of applicant faking should be differentiated across real-life selection settings.
Biomarker Response to a Competitive Season in Division I Female Soccer Players.

Walker, AJ, McFadden, BA, Sanders, DJ, Rabideau, MM, Hofacker, ML, and Arent, SM. Biomarker response to a competitive season in Division I female soccer players. J Strength Cond Res XX(X): 000-000, 2019-The purpose of this study was to evaluate effects of training load (TL) on performance and biomarkers of health, performance, and recovery in Division I female soccer players throughout a competitive season. Participants (N = 25, Mage = 20 ± 1.1 years) were monitored before the start of preseason and every 4-weeks thereafter (T1-T5). A battery of performance tests was administered before the start of preseason (P1) and end-of-season (P2), including body composition (percent body fat [%BF], fat free mass [FFM], and fat mass), vertical jump (VJ), and V[Combining Dot Above]O2max. Blood draws were conducted at every time point (T1-T5) to assess free and total cortisol (CORTF and CORTT), prolactin (PRL), T3, IL-6, creatine kinase (CK), sex-hormone binding globulin, omega-3 (n-3FA), vitamin-D (Vit-D), iron (Fe), hematocrit (HcT), ferritin (Fer), percent saturation (%Sat), and total iron-binding capacity (TIBC). Daily exercise energy expenditure (EEE) and TL were determined. There were significant declines in V[Combining Dot Above]O2max, VJ, weight, and %BF from P1-P2 (p < 0.05) with no significant differences in FFM. Training load and EEE significantly decreased from T1-T3 (p < 0.05). Significant increases were seen in CORTT, CORTF, PRL, T3, IL-6, CK, and TIBC throughout the season (p < 0.05). Significant decreases were seen in n-3FA, Fe, Fer, %Sat, and Hct throughout the season (p < 0.05). Female athletes experience significant physiological changes following high TL and EEE associated with preseason and appear to be further exacerbated by the cumulative effects of the season. Unique insights provided by biomarkers enable athletes and coaches to be cognizant of the physiological changes that are occurring throughout the season.
Distributed Nash Equilibrium Seeking for Aggregative Games With Nonlinear Dynamics Under External Disturbances

In this paper, we study the distributed Nash equilibrium (NE) seeking problem for a class of aggregative games with players described by uncertain perturbed nonlinear dynamics. To seek the NE, each player needs to construct a distributed algorithm based on information of its cost function and the exchanging information obtained from its neighbors. By combining the internal model principle and the average consensus technique, we propose a distributed gradient-based algorithm for the players. This paper not only assures the NE seeking of aggregative games but also achieves the disturbance rejection of external disturbances.
Abnormal fatty acid metabolism is a core component of spinal muscular atrophy

Spinal muscular atrophy (SMA) is an inherited neuromuscular disorder leading to paralysis and subsequent death in young children. Initially considered a motor neuron disease, extra‐neuronal involvement is increasingly recognized. The primary goal of this study was to investigate alterations in lipid metabolism in SMA patients and mouse models of the disease.
Fully automated patellofemoral MRI segmentation using holistically nested networks: Implications for evaluating patellofemoral osteoarthritis, pain, injury, pathology, and adolescent development

Our clinical understanding of the relationship between 3D bone morphology and knee osteoarthritis, as well as our ability to investigate potential causative factors of osteoarthritis, has been hampered by the time‐intensive nature of manually segmenting bone from MR images. Thus, we aim to develop and validate a fully automated deep learning framework for segmenting the patella and distal femur cortex, in both adults and actively growing adolescents.
Number of Antibody-verified Eplet in HLA-C Locus as an Independent Factor of T-cell–Mediated Rejection After Liver Transplantation

Supplemental Digital Content is available in the text. Background. HLA mismatching is a risk factor for graft rejection in solid organ transplantation. Its definition is being rethought with the introduction of the eplets in organ allocation. The eplets are highly polymorphic regions of the HLA molecule that help to explain cross-reactivity of HLA antigens. The effect of eplet mismatch is well documented in renal and lung transplantation but there is no clear evidence in liver transplantation. Methods. Forty-three consecutive liver-graft donor/recipient pairs performed at our center from 2016 to 2018 were HLA typed. The quantification of antibody-verified eplets (VerEp) mismatch was performed with HLA-matchmaker 2.1 version. Results. A total of 9 patients suffered an episode of T-cell–mediated rejection (TCMR). No significant differences were observed in the number of A, B, DRB, DQA, and DQB VerEp. However, the mean of mismatches VerEp in locus C (VerEpC) was significantly increased in patients with acute rejection: 3.89 (1.36) versus 2.32 (1.82), P = 0.021. A total of 22 patients with high load of VerEpC (>2) had an increased risk of TCMR (P = 0.008). The time of TCMR-free after liver transplant was statistically reduced in high-load VerEpC group (log-rank test P = 0.019). Multivariate analysis demonstrated that high load of VerEpC was independently associated with TCMR (P = 0.038). Conclusions. Patients with no or 1 eplet mismatch at the C locus are less likely to suffer TCMR after liver transplantation.
Nuclear expression of β‐catenin in endometrial hyperplasia as marker of premalignancy

We aimed to assess (1)‐whether nuclear β‐catenin is a marker of endometrial precancer, and (2)‐the diagnostic accuracy of β‐catenin immunohistochemistry in the differential diagnosis between benign and premalignant endometrial hyperplasia (EH), defining criteria for its use. Electronic databases were searched for studies evaluating β‐catenin immunohistochemistry in normal endometrium (NE), benign and/or premalignant EH, and endometrioid carcinoma (EC). Odds ratio (OR; p < 0.05), sensitivity, specificity, diagnostic OR (DOR), positive and negative likelihood ratios (LR+, LR−) were calculated. Subgroup analyses were based on the classification system used (WHO or EIN) and criteria to define aberrant β‐catenin expression (only nuclear or cytoplasmic/nuclear). Twelve studies with 1510 specimens were included. Nuclear β‐catenin rate significantly increased from NE to benign EH (OR = 26.01; p = 0.0002, only in WHO subgroup), and from benign EH to premalignant EH (OR = 3.89; p = 0.0002; more markedly in EIN subgroup), but not from premalignant EH to EC (OR = 0.78; p = 0.29). Nuclear β‐catenin accuracy was very low in WHO subgroup (sensitivity = 0.40, specificity = 0.76, LR+ = 1.85, LR− = 0.72; DOR = 2.89) and moderate in EIN subgroup (sensitivity = 0.19, specificity = 1.00, LR+ = 14.80, LR− = 0.83; DOR = 18.14). Cytoplasmic/nuclear β‐catenin accuracy was absent in WHO subgroup (sensitivity = 0.45, specificity = 0.54, LR+ = 1.01, LR− = 1.01; DOR = 0.99) and low in EIN subgroup (sensitivity = 0.57, specificity = 0.86, LR+ = 3.63, LR− = 0.51; DOR = 8.30). Considering nuclear expression and using EIN system, β‐catenin immunohistochemistry might be reliable as rule‐in test for diagnosis of endometrial precancer, with perfect specificity and moderate overall accuracy.
Knowledgeability and modes of identification in (dis)embodied boundary practice in networked learning

Building on a continued interest in boundaries and boundary practice in relation to ICT-based networked learning (Ryberg & Sinclair, 2016), this paper addresses the issue of knowledgeability and identification through (dis)embodiment in design for boundary practice in networked learning. According to Goodyear (2015) teaching is about designing opportunities for people to learn, and from a learning perspective, how participants respond to design through their practices and through their use of boundary objects is interesting. Inspired by Wenger-Trayner & Wenger-Trayner’s (2015) concepts of knowledgeability and modes of identification, we analyse how two different case studies conducted at the Danish online Master programme on ICT and Learning (MIL) differ with regard to potential boundary practice and use of boundary objects. In study I, the design for learning was based on a 2D virtual learning environment (Dirckinck-Holmfeld, 2006), whereas the design for learning in study II was based on a 3D virtual world (Riis, 2016). Carlile (2002; 2004) proposed a hierarchical typology for boundary objects aiming at transfer, translation and transformation, and in our analysis, we identify examples of such boundary objects in the two learning arenas. Our findings show that all identified categories of boundary objects can mediate knowledge according to the typology. Nonetheless, certain boundary objects in the 3D learning arena (study II), in particular the avatar, seem to promote a different kind of embodied transformation, which has implications for identity formation of the participants. Furthermore, the 3D virtual space affords a concrete materialised, albeit virtual, opportunity for reification, which is different to that of the 2D environment. In the paper, we will elaborate on these differences, and based on the two case studies we propose that boundaries in networked learning should not only be regarded as socio-cultural differences, but as sociomaterial differences and dependencies as well. In particular, the materiality of a 3D virtual arena and avatars provides new relational and performative opportunities in networked learning.
On the Difference Between Necessary and Unnecessary Glances Away From the Forward Roadway: An Occlusion Study on the Motorway

Objective The present study strove to distinguish traffic-related glances away from the forward roadway from non-traffic-related glances while assessing the minimum amount of visual information intake necessary for safe driving in particular scenarios. Background Published gaze-based distraction detection algorithms and guidelines for distraction prevention essentially measure the time spent looking away from the forward roadway, without incorporating situation-based attentional requirements. Incorporating situation-based attentional requirements would entail an approach that not only considers the time spent looking elsewhere but also checks whether all necessary information has been sampled. Method We assess the visual sampling requirements for the forward view based on 25 experienced drivers’ self-paced visual occlusion in real motorway traffic, dependent on a combination of situational factors, and compare these with their corresponding glance behavior in baseline driving. Results Occlusion durations were on average 3 times longer than glances away from the forward roadway, and they varied substantially depending on particular maneuvers and on the proximity of other traffic, showing that interactions with nearby traffic increase perceived uncertainty. The frequency of glances away from the forward roadway was relatively stable across proximity levels and maneuvers, being very similar to what has been found in naturalistic driving. Conclusion Glances away from the forward roadway proved qualitatively different from occlusions in both their duration and when they occur. Our findings indicate that glancing away from the forward roadway for driving purposes is not the same as glancing away for other purposes, and that neither is necessarily equivalent to distraction.
Gamma-Band Auditory Steady-State Response as a Neurophysiological Marker for Excitation and Inhibition Balance: A Review for Understanding Schizophrenia and Other Neuropsychiatric Disorders

Altered gamma oscillations have attracted considerable attention as an index of the excitation/inhibition (E/I) imbalance in schizophrenia and other neuropsychiatric disorders. The auditory steady-state response (ASSR) has been the most robust probe of abnormal gamma oscillatory dynamics in schizophrenia. Here, we review recent ASSR studies in patients with schizophrenia and other neuropsychiatric disorders. Preclinical ASSR research, which has contributed to the elucidation of the underlying pathophysiology of these diseases, is also discussed. The developmental trajectory of the ASSR has been explored and may show signs of the maturation and disruption of E/I balance in adolescence. Animal model studies have shown that synaptic interactions between parvalbumin-positive GABAergic interneurons and pyramidal neurons contribute to the regulation of E/I balance, which is related to the generation of gamma oscillation. Therefore, ASSR alteration may be a significant electrophysiological finding related to the E/I imbalance in neuropsychiatric disorders, which is a cross-disease feature and may reflect clinical staging. Future studies regarding ASSR generation, especially in nonhuman primate models, will advance our understanding of the brain circuit and the molecular mechanisms underlying neuropsychiatric disorders.
Interprofessional education placements in allied health: A scoping review

Abstract Aim: This scoping review provides a summary of the features, outcomes and lessons learned of Interprofessional Education (IPE) Placements in Allied Health professional-entry programs. The provision of these placements is one strategy to prepare students for Interprofessional Practice. Methods: Eight databases were systematically searched. Eligibility criteria included Allied-Health interprofessional student groups, professional-entry level programs, interprofessional supervision placements and implementation of a novel model. We accepted all types of peer-reviewed, published papers. Data charting and synthesizing occurred, with a data- subset presented in themes related to the features, outcomes and lessons learnt of IPE Placements. Results: The included 27 papers originate from a variety of countries (2002–2017). Whilst the features of the models varied considerably, features were identified that occurred in a high number of the papers. Positive outcomes were consistently reported for student learning. Thorough planning and investment arose as important themes, ensuring a positive placement experience and understanding of the IPE pedagogy from all stakeholders. Conclusions and Significance: This review provides insights into the features and outcomes of IPE placement models in Allied Health programs. The review expands the body of knowledge which previously focused on nursing and medicine and can inform educators about IPE placement implementation.
Maternal inflammation leads to different mTORC1 activity varied by anatomic locations in mouse placenta†

Abstract Maternal inflammation (MI) is associated with many adverse perinatal outcomes. The placenta plays a vital role in mediating maternal-fetal resource allocation. Studies have shown that MI contributes to placental dysfunction, which then leads to adverse birth outcomes and high health risks throughout childhood. Placental mammalian target of rapamycin complex 1 (mTORC1) signaling pathway links maternal nutrient availability to fetal growth; however, the impact of MI on mTORC1 signaling in the placenta remains unclear. In this study, we sought to explore the changes of mTORC1 signaling in the mouse placenta at late gestation by using two models of MI employing lipopolysaccharide (LPS) and interleukin-1β (IL-1β) to mimic acute (aMI) and sub-chronic (cMI) inflammatory states, respectively. We determined placental mTORC1 activity by measuring the activity of mTORC1 downstream molecules, including S6k, 4Ebp1, and rpS6. In the aMI model, we found that mTORC1 activity was significantly decreased in the placental decidual and junctional zone at 2 and 6 h after LPS surgery, respectively; however, mTORC1 activity was significantly increased in the placental labyrinth zone at 2, 6, and 24 h after LPS treatment, respectively. In the cMI model, we observed that mTORC1 activity was increased only in the placental labyrinth zone after consecutive IL-1β exposure. Our study reveals that different parts of the mouse placenta react differently to MI, leading to variable mTORC1 activity throughout the placenta. This suggests that different downstream molecules of mTORC1 from different parts of the mouse placenta may be used in clinical research to monitor the fetal well-being during MI. Summary Sentence The downstream molecules of mTORC1 may be used as sensitive biomarkers to monitor fetal well-being after exposure to maternal inflammation.