Miracle-dz/UniFAR-FTUs huggingface dataset:
Mother's Own Milk and Bronchopulmonary Dysplasia: A Systematic Review and Meta-Analysis

Background: Bronchopulmonary dysplasia (BPD) is the most common complication of very preterm birth and can lead to lifelong health consequences. Optimal nutrition is a cornerstone in the prevention and treatment of BPD. In very preterm infants, mother's own milk (MOM) feeding is associated with lower risks of necrotizing enterocolitis, retinopathy of prematurity, and sepsis. Although several studies have shown that MOM may protect against BPD, a systematic analysis of the evidence has not been performed to date. Methods: A comprehensive literature search was conducted using PubMed/MEDLINE and EMBASE, from their inception to 1 December 2017. Longitudinal studies comparing the incidence of BPD in preterm infants fed with exclusive MOM, MOM supplemented with preterm formula (PF), and/or exclusively fed with PF were selected. A random-effects model was used to calculate the Mantel Haenszel risk ratio (RR) and 95% confidence interval (CI). Results: Fifteen studies met the inclusion criteria (4,984 infants, 1,416 BPD cases). Use of exclusive MOM feedings was associated with a significant reduction in the risk of BPD (RR 0.74, 95% CI 0.57–0.96, 5 studies). In contrast, meta-analysis could not demonstrate a significant effect on BPD risk when infants fed with more than 50% MOM were compared with infants fed with <50% MOM (RR 0.98, 95% CI 0.77–1.23, 10 studies) or when infants fed with MOM supplemented with PF were compared with infants fed with exclusive PF (RR 1.00, 95% CI 0.78–1.27, 6 studies). Meta-regression showed that differences in gestational age were a significant confounder of the effect of MOM. Conclusion: To our knowledge, this is the first systematic review and meta-analysis that specifically evaluates the role of MOM on BPD. Our data indicate that MOM may reduce the incidence of BPD when used as an exclusive diet, but this result needs to be interpreted with caution. We did not find the same difference in analyses with other dosages of MOM. Further studies adequately powered to detect changes in BPD rates and that adjust for confounders are needed to confirm the beneficial effects of MOM on BPD.
Platelet Contributions to Myocardial Ischemia/Reperfusion Injury

Obstruction of a coronary artery causes ischemia of heart tissue leading to myocardial infarction. Prolonged oxygen deficiency provokes tissue necrosis, which can result in heart failure and death of the patient. Therefore, restoration of coronary blood flow (reperfusion of the ischemic area) by re-canalizing the affected vessel is essential for a better patient outcome. Paradoxically, sudden reperfusion also causes tissue injury, thereby increasing the initial ischemic damage despite restoration of blood flow (=ischemia/reperfusion injury, IRI). Myocardial IRI is a complex event that involves various harmful mechanisms (e.g., production of reactive oxygen species and local increase in calcium ions) as well as inflammatory cells and signals like chemokines and cytokines. An involvement of platelets in the inflammatory reaction associated with IRI was discovered several years ago, but the underlying mechanisms are not yet fully understood. This mini review focusses on platelet contributions to the intricate picture of myocardial IRI. We summarize how upregulation of platelet surface receptors and release of immunomodulatory mediators lead to aggravation of myocardial IRI and subsequent cardiac damage by different mechanisms such as recruitment and activation of immune cells or modification of the cardiac vascular endothelium. In addition, evidence for cardioprotective roles of distinct platelet factors during IRI will be discussed.
Life is as much a pain as it ever was

EDITOR—The article by Palmer et al shows that the reporting of back pain in the United Kingdom has increased during the past decade.1 This is potentially important because, despite rises in indirect measures such as sickness and invalidity benefit payments for back pain in the United Kingdom and elsewhere, there has been little evidence that back pain is actually becoming more common.2 Area defined as low back in studies 3 4 We conducted two …
Circuit Analysis of a Drosophila Dopamine Type 2 Receptor That Supports Anesthesia-Resistant Memory

Dopamine is central to reinforcement processing and exerts this function in species ranging from humans to fruit flies. It can do so via two different types of receptors (i.e., D1 or D2) that mediate either augmentation or abatement of cellular cAMP levels. Whereas D1 receptors are known to contribute to Drosophila aversive odor learning per se, we here show that D2 receptors are specific for support of a consolidated form of odor memory known as anesthesia-resistant memory. By means of genetic mosaicism, we localize this function to Kenyon cells, the mushroom body intrinsic neurons, as well as GABAergic APL neurons and local interneurons of the antennal lobes, suggesting that consolidated anesthesia-resistant memory requires widespread dopaminergic modulation within the olfactory circuit. Additionally, dopaminergic neurons themselves require D2R, suggesting a critical role in dopamine release via its recognized autoreceptor function. Considering the dual role of dopamine in balancing memory acquisition (proactive function of dopamine) and its “forgetting” (retroactive function of dopamine), our analysis suggests D2R as central player of either process. SIGNIFICANCE STATEMENT Dopamine provides different information; while it mediates reinforcement during the learning act (proactive function), it balances memory performance between two antithetic processes thereafter (retroactive function) (i.e., forgetting and augmentation). Such bidirectional design can also be found at level of dopamine receptors, where augmenting D1 and abating D2 receptors are engaged to balance cellular cAMP levels. Here, we report that consolidated anesthesia-resistant memory (ARM), but not other concomitant memory phases, are sensitive to bidirectional dopaminergic signals. By means of genetic mosaicism, we identified widespread dopaminergic modulation within the olfactory circuit that suggests nonredundant and reiterating functions of D2R in support of ARM. Our results oppose ARM to its concomitant memory phases that localize to mushroom bodies and propose a decentralized organization of consolidated ARM.
Response of the Chinese Soft-Shelled Turtle to Acute Heat Stress: Insights From the Systematic Antioxidant Defense

Understanding the responses of animals to acute heat stress can help to reveal and predict the effect of more frequent extreme hot weather episodes on animal populations and ecosystems in the content of global climate change. Antioxidant defenses can help to protect animals against oxidative stress caused by intense temperature variation. In the present study, systematic antioxidant responses to acute heat stress (Δ15°C and maintained for 12 h) and subsequent recovery were assessed by evaluating gene transcript levels and relative enzyme activities in tissues of Pelodiscus sinensis, a subtropical freshwater turtle. Targets included nuclear factor erythroid 2-related factor 2 (Nrf2, the upstream transcription factor), antioxidant enzymes, and the glutathione (GSH) and ascorbic acid (AA) systems. Results showed three main patterns of expression change among antioxidant genes: (1) gene expression of Mn-superoxide dismutase (Mn-SOD), glutathione peroxidase 4 (GPx 4), and catalase (CAT) increased in response to heat stress or recovery in the liver; (2) transcripts of most genes did not change in brain, liver, and kidney of P. sinensis; and (3) expression of several GST isoforms were affected by heat stress or recovery in brain and kidney. However, relative enzyme activities involved in antioxidant defense were little affected by acute heat stress and recovery, indicating a relatively conservative antioxidant response in P. sinensis. Furthermore, results for malondialdehyde (MDA) levels indicated that acute heat stress and recovery did not cause a net increase in oxidative damage in turtle tissues and, in particular, MDA levels in spleen decreased along with increased splenic ascorbic acid concentration. Overall, the present study revealed a conservative antioxidant response in P. sinensis, which may be indicative of a high basal stress tolerance and relate with adaptation to climate change in freshwater turtles.
Evaluating Different Equating Setups in the Continuous Item Pool Calibration for Computerized Adaptive Testing

The increasing digitalization in the field of psychological and educational testing opens up new opportunities to innovate assessments in many respects (e.g., new item formats, flexible test assembly, efficient data handling). In particular, computerized adaptive testing provides the opportunity to make tests more individualized and more efficient. The newly developed continuous calibration strategy (CCS) from Fink et al. (2018) makes it possible to construct computerized adaptive tests in application areas where separate calibration studies are not feasible. Due to the goal of reporting on a common metric across test cycles, the equating is crucial for the CCS. The quality of the equating depends on the common items selected and the scale transformation method applied. Given the novelty of the CCS, the aim of the study was to evaluate different equating setups in the CCS and to derive practical recommendations. The impact of different equating setups on the precision of item parameter estimates and on the quality of the equating was examined in a Monte Carlo simulation, based on a fully crossed design with the factors common item difficulty distribution (bimodal, normal, uniform), scale transformation method (mean/mean, mean/sigma, Haebara, Stocking-Lord), and sample size per test cycle (50, 100, 300). The quality of the equating was operationalized by three criteria (proportion of feasible equatings, proportion of drifted items, and error of transformation constants). The precision of the item parameter estimates increased with increasing sample size per test cycle, but no substantial difference was found with respect to the common item difficulty distribution and the scale transformation method. With regard to the feasibility of the equatings, no differences were found for the different scale transformation methods. However, when using the moment methods (mean/mean, mean/sigma), quite extreme levels of error for the transformation constants A and B occurred. Among the characteristic curve method the performance of the Stocking-Lord method was slightly better than for the Haebara method. Thus, while no clear recommendation can be made with regard to the common item difficulty distribution, the characteristic curve methods turned out to be the most favorable scale transformation methods within the CCS.
Commentary: Tropical fish diversity enhances coral reef functioning across multiple scales

We demonstrate that the conclusions drawn by Lefcheck et al. (2019) regarding the positive effects of fish diversity on coral reef ecosystem functioning across scales are flawed because of a series of conceptual and statistical issues that include spurious correlations, the conflation of population size and species diversity effects and a failure to recognize that observing a biodiversity effect at multiple sites is not equivalent to observing it at multiple scales.
The Effect of Mindfulness Interventions for Parents on Parenting Stress and Youth Psychological Outcomes: A Systematic Review and Meta-Analysis

Background: The psychological well-being of parents and children is compromised in families characterized by greater parenting stress. As parental mindfulness is associated with lower parenting stress, a growing number of studies have investigated whether mindfulness interventions can improve outcomes for families. This systematic review and meta-analysis evaluates the effectiveness of mindfulness interventions for parents, in reducing parenting stress and improving youth psychological outcomes. Methods: A literature search for peer-reviewed articles and dissertations was conducted in accordance with PRISMA guidelines in the PsycInfo, Medline, PubMed, CINAHL, Web of Science, Cochrane Central Register of Controlled Trials, and ProQuest Dissertations & Theses databases. Studies were included if they reported on a mindfulness-based intervention delivered in person to parents with the primary aim of reducing parenting stress or improving youth psychological outcomes. Results: Twenty-five independent studies were included in the review. Eighteen studies used a single group design and six were randomized controlled trials. Within-groups, meta-analysis indicated a small, post-intervention reduction in parenting stress (g = 0.34), growing to a moderate reduction at 2 month follow-up (g = 0.53). Overall, there was a small improvement in youth outcomes (g = 0.27). Neither youth age or clinical status, nor time in mindfulness training, moderated parenting stress or overall youth outcome effects. Youth outcomes were not moderated by intervention group attendees. Change in parenting stress predicted change in youth externalizing and cognitive effects, but not internalizing effects. In controlled studies, parenting stress reduced more in mindfulness groups than control groups (g = 0.44). Overall, risk of bias was assessed as serious. Conclusions: Mindfulness interventions for parents may reduce parenting stress and improve youth psychological functioning. While improvements in youth externalizing and cognitive outcomes may be explained by reductions in parenting stress, it appears that other parenting factors may contribute to improvements in youth internalizing outcomes. Methodological weaknesses in the reviewed literature prevent firm conclusions from being drawn regarding effectiveness. Future research should address these methodological issues before mindfulness interventions for parents are recommended as an effective treatment option for parents or their children.
Use of Renin–Angiotensin–Aldosterone System Inhibitors in Older Patients with Heart Failure and Reduced Ejection Fraction

Patients enrolled in randomised clinical trials may not be representative of the real-world population of people with heart failure (HF). Older patients are frequently excluded and this limits the strength of evidence which supports the use of specific HF treatments in this patient group. Lack of evidence together with fear of adverse effects, drug interactions and lower tolerance may lead to the undertreatment of older patients and a less favourable outcome. Renin–angiotensin–aldosterone system (RAAS) inhibitors are the cornerstone of treatment for patients with HF with reduced ejection fraction (HFrEF), but despite the class I recommendation for all patients regardless of age in the guidelines, there are signs that RAAS inhibitors are underused among older patients. Large registry-based studies suggest that RAAS inhibitors may be at least as effective in older patients as younger ones, but these findings need to be confirmed by randomised clinical trials.
A Review of Efficacy and Safety of Checkpoint Inhibitor for the Treatment of Acute Myeloid Leukemia

Immune checkpoint inhibitors (ICIs) as positive modulators of immune response have revolutionized the treatment of cancer and have achieved impressive efficacy in melanoma and numerous solid tumor malignancies. These agents are being investigated in acute myeloid leukemia (AML) to further enhance response rate as induction therapy and to improve relapse-free survival (RFS) post chemotherapy and bone marrow transplantation. PD-1 and CTLA-4 are the two most actively investigated checkpoint receptors, which play a role in different stages of anti-tumor immune response. This study reviews data from ongoing phase I, II clinical trials evaluating PD-1 and CTLA-4 inhibitors on AML patients and discusses especially efficacy and adverse events as well as prospects of these drugs in treating AML. Single anti-PD-1 monoclonal antibody infusion shows rather modest clinical efficacy. While combinations of PD-1 inhibitor with hypomethylating agents (HMAs) represent encouraging outcome for relapsed/refractory (R/R) AML patients as well as for elderly patients as first-line therapy option. Adding PD-1 inhibitor to traditional induction therapy regimen is also safe and feasible. CTLA-4 inhibitor ipilimumab exhibits specific potency in treating relapsed AML patients with extramedullary disease in later post-transplantation stage. In terms of side effects, irAEs found in these trials can mostly be appropriately managed with steroids but are occasionally fatal. More rationally designed combinational therapies are under investigation in ongoing clinical trials and will further advance our understanding of checkpoint inhibitors as well as lead us to the most appropriate application of these agents.
Experimental transmission of Sphaerospora renicola to common carp Cyprinus carpio fry

The causative agent of renal sphaerosporosis and swimbladder inflammation was observed in specific-pathogen-free (SPF) carp Cyprinus carpio L of the year following exposure to filtered water from a pond where Sphaerospora renicola Dykova et Lom, 1982 is enzootic. SPF carp showed infected kidney tubules after contact with water filtrates containing particles c 4 5 pm in diameter. Using a Polymon filter the operative diameter of the causative agent could be determined a s being <20 pm as shown by distinct S. renicola infections in SPF carp after exposure to 20 pm filtrate. Previous reports of a direct infechon by contact with spore-releasing donor carp or feeding on spore-containing h d n e y hssue could not be confirmed. It is hypothesized that an actinospore component may be the causahve agent of S. renicola infections in common carp.
A Whole Systems Approach to Hospital Waste Management in Rural Uganda

Introduction: Safe waste management protects hospital staff, the public, and the local environment. The handling of hospital waste in Bwindi Community Hospital did not appear to conform to the hospital waste management plan, exhibiting poor waste segregation, transportation, storage, and disposal which could lead to environmental and occupational risks. Methods: We undertook a mixed-methods study. We used semi-structured interviews to assess the awareness of clinical and non-clinical staff of waste types, risks, good practice, and concerns about hospital waste management. We quantified waste production by five departments for 1 month. We assessed the standard of practice in segregation, onsite transportation, use of personal protective equipment, onsite storage of solid waste, and disposal of compostable waste and chemicals. Results: Clinical staff had good awareness of waste (types, risk) overall, but the knowledge of non-clinical staff was much poorer. There was a general lack of insight into correct personal or departmental practice, resulting in incorrect segregation of clinical and compostable waste at source (>93% of time), and incorrect onsite transportation (94% of time). In 1 month the five departments produced 5,398 kg of hazardous and non-hazardous waste (12; 88%, respectively). Good practice included the correct use of sharps and vial boxes and keeping the clinical area clear of litter (90% of the time); placentae buried immediately (>80% of the time); gloves were worn everyday by waste handlers, but correct heavy-duty gloves <33% of the time, reflecting the variable use of other personal protective equipment. Chemical waste drained to underground soakaways, but tracking further disposal was not possible. Correct segregation of clinical and compostable waste at source, and correct onsite transportation, only occurred 6% of the time. Conclusion: Waste management was generally below the required WHO standards. This exposes people and the wider environment, including the nearby world heritage site, home to the endangered mountain gorilla, to unnecessary risks. It is likely that the same is true in similar situations elsewhere. Precautions, protection, and dynamic policy making should be prioritized in these hospital settings and developing countries.
Multicategories of Multiary Lenses

Recently lens-like definitions of multidirectional transformations have appeared [2], encompassing both a “propagation” form (in the style of [5]) and a “wide span” form (in the style of [6]). These “multiary lenses” raise a number of new challenges that are addressed in this paper. First, in common with classical symmetric lenses, they need to be studied modulo equivalence relations that factor out differences in hidden data and declare two lenses to be equivalent if their observable behaviours correspond. Then, modulo those equivalence relations the precise relationship between the propagation style lenses and the wide span lenses needs to be established. All of this is carried through here. But more significantly, the compositions of multiary lenses proposed to date have suffered various limitations: well-behaved amendment lenses don’t necessarily compose to give well-behaved amendment lenses; technical conditions on model spaces can interfere with composition; junction conditions needed to be introduced because certain kinds of compositions of multiary lenses might not always be defined; and in any case, composition of multiary lenses comes with unusual challenges and can’t be expected to form a category structure since when there are more than two data sources there are not even single notions of domain or codomain for multiary lenses. In this paper we introduce a class of asymmetric amendment lenses called spg-lenses (stable putget lenses) which is more general than well-behaved amendment lenses, but is closed under composition, and we show how to use spg-lenses to capture, via wide spans, a wide class of mutidirectional transformations which compose well and form a well-known and long-standing structure, a multicategory — a multicategory of multiary lenses.
Multimode collective scattering of light in free space by a cold atomic gas

We have studied collective recoil lasing by a cold atomic gas, scattering photons from an incident laser into many radiation modes in free space. The model consists of a system of classical equations for the atomic motion of N atoms where the radiation field has been adiabatically eliminated. We performed numerical simulations using a molecular dynamics code pepc (Pretty Efficient Parallel Coulomb Solver) to track the trajectories of the atoms. These simulations show the formation of an atomic density grating and collective enhancement of scattered light, both of which are sensitive to the shape and orientation of the atomic cloud. In the case of an initially circular cloud, the dynamical evolution of the cloud shape plays an important role in the development of the density grating and collective scattering. The ability to use efficient molecular dynamics codes will be a useful tool for the study of the multimode interaction between light and cold gases.