Miracle-dz/UniFAR-FTUs huggingface dataset:
Stereotactic electroencephalography with temporal grid and mesial temporal depth electrode coverage: does technique of depth electrode placement affect outcome?

OBJECT Intracranial monitoring for temporal lobe seizure localization to differentiate neocortical from mesial temporal onset seizures requires both neocortical subdural grids and hippocampal depth electrode implantation. There are 2 basic techniques for hippocampal depth electrode implantation. This first technique uses a stereotactically guided 8-contact depth electrode directed along the long axis of the hippocampus to the amygdala via an occipital bur hole. The second technique involves direct placement of 2 or 3 4-contact depth electrodes perpendicular to the temporal lobe through the middle temporal gyrus and overlying subdural grid. The purpose of this study was to determine whether one technique was superior to the other by examining monitoring success and complications. METHODS Between 1997 and 2005, 41 patients underwent invasive seizure monitoring with both temporal subdural grids and depth electrodes placed in 2 ways. Patients in Group A underwent the first technique, and patients in Group B underwent the second technique. RESULTS Group A consisted of 26 patients and Group B 15 patients. There were no statistically significant differences between Groups A and B regarding demographics, monitoring duration, seizure localization, or outcome (Engel classification). There was a statistically significant difference at the point in time at which these techniques were used: Group A represented more patients earlier in the series than Group B (p < 0.05). The complication rate attributable to the grids and depth electrodes was 0% in each group. It was more likely that the depth electrodes were placed through the grid if there was a prior resection and the patient was undergoing a new evaluation (p < 0.05). Furthermore, Group A procedures took significantly longer than Group B procedures. CONCLUSIONS In this patient series, there was no difference in efficacy of monitoring, complications, or outcome between hippocampal depth electrodes placed laterally through temporal grids or using an occipital bur hole stereotactic approach. Placement of the depth electrodes perpendicularly through the grids and middle temporal gyrus is technically more practical because multiple head positions and redraping are unnecessary, resulting in shorter operative times with comparable results.
The OGG1 Ser326Cys polymorphism and the risk of esophageal cancer: a meta-analysis.

BACKGROUND The oxoguanine DNA glycosylase (OGG1) Ser326Cys polymorphism has been implicated in susceptibility to esophageal cancer. Several studies investigated the association of this polymorphism with esophageal cancer in different populations. However, the results were contradictory. A meta-analysis was conducted to assess the association between the OGG1 Ser326Cys polymorphism and esophageal cancer susceptibility. METHODS Databases, including PubMed, EMBASE, China National Knowledge Infrastructure (CNKI), and Weipu Database were searched to find relevant studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of associations. A random-effects model was used. RESULTS Twelve studies involving 2363 cases and 3621 controls were included. Overall, a significant association between the OGG1 Ser326Cys polymorphism and esophageal cancer was observed for Cys/Cys versus Cys/Ser+Ser/Ser (OR=1.40; 95% CI 1.12-1.74; p=0.003; Pheterogeneity=0.18). In the subgroup analysis by ethnicity, a significant association was found among Asians (OR=1.51; 95% CI 1.15-1.96; p=0.002; Pheterogeneity=0.22), but not among Caucasians (OR=1.21; 95% CI 0.81-1.81; p=0.35; Pheterogeneity=0.21). In the subgroup analysis by pathologic type, we found that the Cys/Cys genotype was associated with increased esophageal squamous cell carcinoma risk (OR=1.86; 95% CI 1.36-2.53; p<0.0001; Pheterogeneity=0.73). CONCLUSIONS This meta-analysis suggested that the OGG1 Ser326Cys polymorphism was a risk factor of esophageal cancer.
Psychiatric comorbidity in white and African-American cocaine addicts seeking substance abuse treatment.

OBJECTIVE Few diagnostic studies have reported rates of psychiatric comorbidity among cocaine addicts according to race. This study examines psychiatric comorbidity in African-American and white cocaine addicts. METHODS Rates of psychiatric comorbidity were assessed in 263 cocaine addicts seeking substance abuse treatment. The sample included 163 non-Hispanic whites and 100 African Americans. Diagnoses were based on patient interviews using the Schedule for Affective Disorders and Schizophrenia-Lifetime Version (SADS-L). The SADS-L was supplemented to include DSM-III-R criteria for substance abuse or dependence and other psychiatric diagnoses and DSM-III criteria for attention deficit disorder. RESULTS Overall, 55.7 percent of the cocaine addicts met Research Diagnostic Criteria for a current psychiatric diagnosis, and 73.5 percent met criteria for a lifetime psychiatric diagnosis. Whites and African Americans did not differ significantly in overall psychiatric comorbidity. However, whites had significantly higher rates of life-time major depression, alcohol dependence, attention deficit disorder, and conduct disorder. African-American addicts, particularly women, were more likely to meet criteria for a current diagnosis of phobia. CONCLUSIONS Psychiatric comorbidity is common among cocaine addicts, and the rates for specific disorders vary by race. Differences in current and lifetime rates should be noted. Cocaine addicts seeking treatment should be assessed for comorbid alcohol dependence and other psychiatric disorders, including anxiety, affective, and personality disorders.
Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits

ABSTRACT Anthocyanins are colored water-soluble pigments belonging to the phenolic group. The pigments are in glycosylated forms. Anthocyanins responsible for the colors, red, purple, and blue, are in fruits and vegetables. Berries, currants, grapes, and some tropical fruits have high anthocyanins content. Red to purplish blue-colored leafy vegetables, grains, roots, and tubers are the edible vegetables that contain a high level of anthocyanins. Among the anthocyanin pigments, cyanidin-3-glucoside is the major anthocyanin found in most of the plants. The colored anthocyanin pigments have been traditionally used as a natural food colorant. The color and stability of these pigments are influenced by pH, light, temperature, and structure. In acidic condition, anthocyanins appear as red but turn blue when the pH increases. Chromatography has been largely applied in extraction, separation, and quantification of anthocyanins. Besides the use of anthocyanidins and anthocyanins as natural dyes, these colored pigments are potential pharmaceutical ingredients that give various beneficial health effects. Scientific studies, such as cell culture studies, animal models, and human clinical trials, show that anthocyanidins and anthocyanins possess antioxidative and antimicrobial activities, improve visual and neurological health, and protect against various non-communicable diseases. These studies confer the health effects of anthocyanidins and anthocyanins, which are due to their potent antioxidant properties. Different mechanisms and pathways are involved in the protective effects, including free-radical scavenging pathway, cyclooxygenase pathway, mitogen-activated protein kinase pathway, and inflammatory cytokines signaling. Therefore, this review focuses on the role of anthocyanidins and anthocyanins as natural food colorants and their nutraceutical properties for health. Abbreviations: CVD: Cardiovascular disease VEGF: Vascular endothelial growth factor
Nucleic acid-based biomarkers in body fluids of patients with urologic malignancies

Abstract This review focuses on the promising potential of nucleic acids in body fluids such as blood and urine as diagnostic, prognostic, predictive and monitoring biomarkers in urologic malignancies. The tremendous progress in the basic knowledge of molecular processes in cancer, as shown in the companion review on nucleic acid-based biomarkers in tissue of urologic tumors, provides a strong rationale for using these molecular changes as non-invasive markers in body fluids. The changes observed in body fluids are an integrative result, reflecting both tissue changes and processes occurring in the body fluids. The availability of sensitive methods has only recently made possible detailed studies of DNA- and RNA-based markers in body fluids. In addition to these biological aspects, methodological aspects of the determination of nucleic acids in body fluids, i.e. pre-analytical, analytical and post-analytical issues, are particularly emphasized. The characteristic changes of RNA (differential mRNA and miRNA expression) and DNA (concentrations, integrity index, mutations, microsatellite and methylation alterations) in serum/plasma and urine samples of patients suffering from the essential urologic cancers of the prostate, bladder, kidney and testis are summarized and critically discussed below. To translate the promising results into clinical practice, laboratory scientists and clinicians have to collaborate to resolve the challenges of harmonized and feasible pre-analytical and analytical conditions for the selected markers and to validate these markers in well-designed and sufficiently powered multi-center studies.
Bcl10 Controls TCR- and FcγR-Induced Actin Polymerization1

Bcl10 plays an essential role in the adaptive immune response, because Bcl10-deficient lymphocytes show impaired Ag receptor-induced NF-κB activation and cytokine production. Bcl10 is a phosphoprotein, but the physiological relevance of this posttranslational modification remains poorly defined. In this study, we report that Bcl10 is rapidly phosphorylated upon activation of human T cells by PMA/ionomycin- or anti-CD3 treatment, and identify Ser138 as a key residue necessary for Bcl10 phosphorylation. We also show that a phosphorylation-deficient Ser138/Ala mutant specifically inhibits TCR-induced actin polymerization yet does not affect NF-κB activation. Moreover, silencing of Bcl10, but not of caspase recruitment domain-containing MAGUK protein-1 (Carma1) induces a clear defect in TCR-induced F-actin formation, cell spreading, and conjugate formation. Remarkably, Bcl10 silencing also impairs FcγR-induced actin polymerization and phagocytosis in human monocytes. These results point to a key role of Bcl10 in F-actin-dependent immune responses of T cells and monocytes/macrophages.
Remote Presence Proctoring by Using a Wireless Remote-Control Videoconferencing System

Remote presence in an operating room to allow an experienced surgeon to proctor a surgeon has been promised through robotics and telesurgery solutions. Although several such systems have been developed and commercialized, little progress has been made using telesurgery for anything more than live demonstrations of surgery. This pilot project explored the use of a new videoconferencing capability to determine if it offers advantages over existing systems. The video conferencing system used is a PC-based system with a flat screen monitor and an attached camera that is then mounted on a remotely controlled platform. This device is controlled from a remotely placed PC-based videoconferencing system computer outfitted with a joystick. Using the public Internet and a wireless router at the client site, a surgeon at the control station can manipulate the videoconferencing system. Controls include navigating the unit around the room and moving the flat screen/camera portion like a head looking up/down and righttleft. This system (InTouch Medical, Santa Barbara, CA) was used to proctor medical students during an anatomy class cadaver dissection. The ability of the remote surgeon to effectively monitor the students' dissections and direct their activities was assessed subjectively by students and surgeon. This device was very effective at providing a controllable and interactive presence in the anatomy lab. Students felt they were interacting with a person rather than a video screen and quickly forgot that the surgeon was not in the room. The ability to move the device within the environment rather than just observe the environment from multiple fixed camera angles gave the surgeon a similar feel of true presence. A remote-controlled videoconferencing system provides a more real experience for both student and proctor. Future development of such a device could greatly facilitate progress in implementation of remote presence proctoring.
Nonlinear Viscoelasticity and the Formation of Transverse Ridges

Transverse ridges are regions of anomalously high uplift that, run parallel to many of the transform fattits at mid-ocean ridges. Previous models of the formation of these ridges generally fail to explain the magnitude of uphft (between 1 and 8 km) or account for geophysical observations (which indicate that the ridges are dynamically uphfted by neutral or heavy, but not buoyant, material). However, the potentially large Maxwell relaxation time of the lithosphere and the high strain rates and finite deformation of transform faults imply that nonlinear viscoelasticity may play an important role in the formation of these ridges. We present simple theoretical and experimental models of viscoelastic flow beneath a transform fattit to show that the purely horizontal motion of the fattit can generate vertical uplift typical of transverse ridges. The theoretical model is of an infinite half-space of fluid driven from above by two plates moving parallel and in opposite directions to one another. The constitutive relation for the viscoelastic rheology is for a second-order fluid; i.e., nonlinear viscoelastic effects are treated as perturbations to Newtonian, purely viscous flow. The theoretical model not only predicts the two transverse ridges that are often observed on either side of the transform fault, but the central transform valley that separates them as well. For typical hthospheric flexural rigidity and deformation associated with transverse ridges, the viscoelastic effect provides sufficient vertical stress to produce the observed uplift. Further, the dynmnic uplift, is a purely mechanical effect (i.e., it does not involve buoyant materiM) which corresponds to geophysical observations. The experimental model is comprised of a viscoelastic fluid (2% aqueous solution of high molecular weight carboxymethylcellulose) driven by a rotating plate. This is analogous to a t. ransk,rm fattit because the boundary of a spiroting circular tectonic plate (surrounded by stationary plates) is one continuous transform fattit. The experiment produces a large ridge of fluid along the edge of the plate with a shght trough outside of the ridge; this result is qualitatively described by a cyhnch-ical version of of the above theoretical model. In conclusion, both experimental and theoretical models show that when nonlinear
Human capital in the banking sector cross cultural definition

Businesses around the world proclaim their employees as being the corporation’s most valuable resource. The field of human capital (HC) is not a new one and, studies focussing specifically on HC and its importance to organisations have been published in the academic press for several decades (Amit & Zott, 2001; Barney & Wright, 1998; Otoo & Mishra, 2018; Wernerfelt, 1984). However, despite continuous research attention, HC remains underdeveloped and an under- researched concept (Gambardella, Panico, & Valentini, 2015; Lewis & Heckman, 2006; McDonnell, 2011). Specially, there is an absence of uniformity in the meanings of term human capital, thus, this exploratory research inquired from those who make use of the concept to define it. Research methods will include interviews with 10 banks in Sri Lanka and New Zealand and secondary sources. Data analysis was carried out using content analysis. The findings revealed that there is a greater likelihood of banks in both countries defined the term HC in a similar way to a greater extent though the differences exist. The findings further, offered an insight for future investigations on how the definition of a developing country differ from that of a developed country.
Audit Specialization and Audit Quality: The Role of Client’s Business Strategy

This study examines how client business strategies moderate the relationship between specialist industry auditors and audit quality. The results show that auditor specialization negatively affects the audit quality, and client’s business strategy negatively affects (weakens) the negative relationship between auditor specialization with auditor quality. These test results support the hypothesis of reduced knowledge gap.
Environmental management practice and environmental performance: the indirect effect of managers attributes

Activities related to environmental management practices (EMP) have been recently discussed in the hospitality industry. With the growth of the Tourism industry around the world, the new trends of tourism direct to Responsible Tourism and Meaningful Tourism which need “everything Green,” the practice of environmental management has been introduced. However, among the environmental issues discussed in the hospitality industry, the role of managers’ attributes on environmental issues is rarely investigated. Therefore, this paper studies the role of manager attributes (MA) on the relationship between EMP and EP. A survey was administered to 350 managers from 4 and 5 star hotels, which were derived from Hotel Accommodation Booklet produced by Tourism Malaysia. The response rate was 11.7%. Partial least square was used to conduct the analysis. The study indicates that EMP has no contribution to the environmental performance, but the relationship turns significant when MA are considered as a moderator.
Pancreatic cancer, alcohol, diabetes mellitus and gall‐bladder disease

A case‐control study comprising 216 cases of pancreatic cancer and 279 controls was conducted to investigate the relationship of pancreatic cancer with certain chronic medical conditions and with the consumption of tea, coffee and alcoholic beverages. Significant positive associations with preexisting diabetes mellitus and gall‐bladder disease were observed and there was weak evidence of association with liver disease. The relative risks for diabetes mellitus and gallstones diagnosed at least one year previously were 4.1 (p = 0.005) and 2.8 (p = 0.01) respectively. Cases drank significantly more beer than controls (p = 0.005) and there was evidence of a positive trend in risk with total alcohol consumption. Smoking was a clear risk factor, but cases and controls were very similar with respect to tea and coffee drinking habits.
Exploratory Analysis of Modbus and general IT network flows in Water SCADA System

Monitoring computer network communications is an essential component for detecting suspicious activities in industrial control networks. There is a growing literature on intrusion detection leveraging the collection of network traces for industrial control systems. Most of these efforts rely on building a profile of normal network activity and then use it to flag anomalies and outliers as potential events worth of investigation. In this paper we analyze the SCADA network traffic from a water treatment system in Texas and show differences between regular IT network packets, and SCADA-specific network packets. These unique properties of SCADA network traffic can be used to build profiles of normal behavior and then used to identify future anomalies not conforming with expected patterns.
3D Conformal Radiotherapy and Cisplatin for Recurrent Malignant Glioma

Purpose : To determine the maximum tolerated dose of 3D conformal radiotherapy in combination with Cisplatin for patients with recurrent malignant gliomas. Methods : From 1999-2003, nine patients with recurrent malignant glioma received fractionated radiotherapy and Cisplatin (20 mg/m2/d IV on days 1-5) in a Phase I radiation dose escalation trial. Three sequential dose levels were evaluated: 25 Gy, 30 Gy, and 35 Gy, using 5 Gy fractions. All patients received prior external beam radiation (median dose 59.4 (20-60) Gy) and five patients received prior chemotherapy. Results : Six male and three female patients were enrolled with a median age of 52 years, and a median Karnofsky performance status score of 70. The median re-irradiated tumor volume was 18.9 (0.1-78.5) cm3 and the median follow-up was 8.8 (3.2-31.2) months. One patient (30 Gy/ 6 fractions) experienced medically reversible acute grade 3 toxicity. A second patient (35 Gy/ 7 fractions) experienced acute grade 2 toxicity and histology showed tumor and radiation effect. A third patient (25 Gy/ 5 fractions) experienced late grade 3 toxicity from radiation necrosis. The radiological responses consisted of complete response (1 patient), partial response (1 patient), and stable disease (2 patients). The median overall survival was 8.8 months (95% CI 8.0-9.9), and the median disease free interval was 2.0 months (95% CI 1.4-4.4). Seven patients received chemotherapy following re-irradiation and Cisplatin. Conclusion : The maximum tolerated dose of 3D conformal fractionated radiotherapy was 30 Gy in 6 fractions with low dose Cisplatin, which was well tolerated in terms of acute toxicity for our patient population. This regimen demonstrated only modest efficacy in the treatment of recurrent malignant glioma. Combinations of conformal re-irradiation and other systemic agents may merit investigation. Currently our recommended dose is 30 Gy in 6 fractions for selected patients.
Year : 2010 Enjoying and fearing laughter : Personality characteristics of gelotophobes , gelotophiles , and

People differ in the way they deal with ridicule. The study examines the personality correlates of those who fear being laughed at (gelotophobes), those who enjoy being laughed at (gelotophiles) and those who enjoy laughing at others (katagelasticists). Gelotophobes do not interpret laughter by others as something positive but more as a mean to put them down. Gelotophiles enjoy being laughed at and interpret the laughter by others positively, as a sign of appreciation. Katagelasticists enjoy laughing at others and do not feel that there is anything wrong in doing so. In an empirical study (N = 394), gelotophobia, gelotophilia, and katagelasticism were related to the PEN-model. Gelotophobes were found to be introverted neurotics. Gelotophilia was primarily related to extraversion and in a multiple regression analysis gender (higher among males) turned out to be predictive as well. Katagelasticists were found to be younger males with higher scores in extraversion and psychoticism. Overall, in a regression analysis the content scales of the short form of the EPQ-R predicted gelotophobia best, but gelotophilia and katagelasticism also yielded robust relations.