Miracle-dz/UniFAR-FTUs huggingface dataset:
The t(8;21) translocation in acute myeloid leukemia results in production of an AML1‐MTG8 fusion transcript.

The t(8;21) translocation is one of the most frequent chromosome abnormalities in acute myeloid leukemia. It has been shown that the t(8;21) breakpoints on chromosome 21 cluster within a single specific intron of the AML1 gene, which is highly homologous to the Drosophila segmentation gene runt. Here we report that this translocation juxtaposes the AML1 gene with a novel gene, named MTG8, on chromosome 8, resulting in the synthesis of an AML1‐MTG8 fusion transcript. The fusion protein predicted by the AML1‐MTG8 transcript consists of the runt homology region of AML1 and the most part of MTG8, which contains putative zinc finger DNA binding motifs and proline‐rich regions constituting a characteristic feature of transcription factors. The MTG8 gene is not expressed in normal hematopoietic cells, whereas AML1 is expressed at high levels. Our results indicate that the production of chimeric AML1‐MTG8 protein, probably a chimeric transcription factor, may contribute to myeloid leukemogenesis.
Proinflammatory and hypofibrinolytic phenotype in healthy first‐degree relatives of patients with Type 2 diabetes

propeptide to identify patients with type 1 vonWillebrand disease with decreased VWF survival. Blood 2006; 108: 3344–51. 8 Gallinaro L, Cattini MG, Sztukowska M, Padrini R, Sartorello F, Pontata E, Bertomoro A, Dandone V, Pagnan A, Casonato A. A shorter von Willebrand factor survival in O blood group subjects explains how ABO determinants influence plasma von Willebrand factor. Blood 2008; 111: 3540–5. 9 Gill JC, Endres-Brooks J, Bauer PJ, Marks WJ Jr, Montgomery RR. The effect of ABO blood group on the diagnosis of von Willebrand disease. Blood 1987; 69: 1691–5. 10 Castaman G, Eikenboom JC. ABO blood group also influences the vonWillebrand factor (VWF) antigen level in heterozygous carriers of VWF null alleles, type 2N mutation Arg854Gln, and the missense mutation Cys2362Phe. Blood 2002; 100: 1927–8. 11 CastamanG, Lethagen S, Federici AB, Tosetto A, Goodeve A, Budde U, Batlle J, Meyer D, Mazurier C, Fressinaud E, Goudemand J, Eikenboom J, Schneppenheim R, Ingerslev J, Vorlova Z, Habart D, Holmberg L, Pasi J, Hill F, Peake I, et al.Response to desmopressin is influenced by the genotype and phenotype in type 1 von Willebrand disease (VWD): results from the European Study MCMDM-1VWD. Blood 2008; 111: 3531–9. 12 Haberichter SL, Castaman G, Budde U, Peake I, Goodeve A, Rodeghiero F, Federici AB, Batlle J, Meyer D, Mazurier C, Goudemand J, Eikenboom J, Schneppenheim R, Ingerslev J, Vorlova Z, Habart D, Holmberg L, Lethagen S, Pasi J, Hill FG, et al. Identification of type 1 von Willebrand disease patients with reduced von Willebrand factor survival by assay of the VWF propeptide in the European study: molecular and clinical markers for the diagnosis and management of type 1 VWD (MCMDM-1VWD). Blood 2008; 111: 4979–85. 13 Lenting PJ, van Schooten CJM, Denis CV. Clearance mechanisms of von Willebrand factor and factor VIII. J Thromb Haemost 2007; 5: 1353–60.
Exact Projective Excitations of Nonautonomous Nonlinear Schrödinger System in (1 + 1)-Dimensions

With the aid of a direct projective approach, a general transformation solution for the nonautonomous nonlinear Schrodinger (NLS) system is derived. Based on certain known exact solutions of the projective equation, some periodic and localized excitations with novel properties are correspondingly revealed by entrancing appropriate system parameters. The integrable constraint conditions for the nonautonomous NLS system derived naturally here are consistent with the compatibility condition via the Painleve analysis in other literatures.
Evaluating the impact of accreditation and external peer review.

PURPOSE Accreditation and external peer review play important roles in assessing and improving healthcare quality worldwide. Evidence on the impact on the quality of care remains indecisive because of programme features and methodological research challenges. The purpose of this paper is to create a general methodological research framework to design future studies in this field. DESIGN/METHODOLOGY/APPROACH A literature search on effects of external peer review and accreditation was conducted using PubMed/Medline, Embase and Web of Science. Three researchers independently screened the studies. Only original research papers that studied the impact on the quality of care were included. Studies were evaluated by their objectives and outcomes, study size and analysis entity (hospitals vs patients), theoretical framework, focus of the studied programme, heterogeneity of the study population and presence of a control group. FINDINGS After careful selection 50 articles were included out of an initial 2,025 retrieved references. Analysis showed a wide variation in methodological characteristics. Most studies are performed cross-sectionally and results are not linked to the programme by a theoretical framework. ORIGINALITY/VALUE Based on the methodological characteristics of previous studies the authors propose a general research framework. This framework is intended to support the design of future research to evaluate the effects of accreditation and external peer review on the quality of care.
Predominance of Left Ear in Meniére's Disease, Sudden Deafness, Inner Ear Damage, Tinnitus and Abnormally Patent Eustachian Tube

Introduction Statistics in the literature show Meniere 's disease, sudden deafness, tinnitus and inner ear damage predominate in the left ear (10-20%). However, ischemic brain infarcts and diseases of the eyes appear with the same incidence on either side. Medialization of the tympanic membrane in atelectasis is known for many years. Since 1977 we have observed the opposite disease picture in patients with "relatively more patulous eustachian tubes," (RMPET), in which the tympanic memb ranes are relatively lateralized. The left ear is predominant with more than 10%. Diagnosis is made under observation of the operating microscope (Iateralization of Shrapnell' s membrane and umbo), by Valsalva's test (which side opens first), and by tympanogram (the curve may be elevated as only nose blowing is a physiological test of the tube). Our examinations have revealed unilateral tinnitus, inner ear damage, sudden deafness, loss of labyrinthine function,vertigo (Meniere) and ankylosis of malleus head on the RMPET side. Unphy siologicalmovements of the round windo w (and oval window) can work like the membrane of a gasoline pump leading to increased loss of perilymph either by diuretic hormones (reacting to pressure) or through the cochlear aquaduct. Greater loss of perilymph results in subsequent enlargement of the endolymphatic space. The patient is advised to avoid nose blowing. Surgical correction of a deviated septum and remova l of large posterior ends of the lower turbinates can reduce overpressure in the middle ear and improve hearing and vertigo in early stages. A "palisade cartilage and perichond riumplasty" stabilizing the round window membrane and the tympanic membrane can improve vertigo comp laints without deterioration of hearing
Mental Health Effects of Premigration Trauma and Postmigration Discrimination on Refugee Youth in Canada

Abstract This report examines the role of pre- and post-migration trauma in explaining differences in refugee and immigrant mental health. Data were derived from mother-youth refugee and immigrant dyads from six countries of origin who were living in Canada at the time of the study. Youth reports of emotional problems (EP) and aggressive behavior (AB) were the mental health outcomes. EP and AB were regressed on predictor blocks: a) status (refugee versus immigrant), visible minority, and gender; b) premigration trauma and postmigration discrimination; c) parent and youth human and social capital; d) poverty, neighborhood, and schools. Refugees suffered higher levels of EP and AB, premigration traumas, and discrimination. Postmigration perception of discrimination predicted both EP and AB and explained immigrant versus refugee differences in EP. Antirefugee discrimination net of discrimination based on immigrant or visible minority status has deleterious mental health consequences.
Minimal Clinically Important Differences in COPD: Body Mass Index and Muscle Strength

Weight loss, muscle wasting, as well as muscle dysfunction are recognized as important problems in COPD, contributing to morbidity and mortality. This paper discusses body weight and muscle function as possible outcome parameters in the management of COPD. The relationship between these outcome measures and COPD-related management goals is discussed. Minimal clinically important differences (MCID) in the approach of patients suffering from COPD for these measures are discussed.
Fertility and pregnancy outcomes following uterine devascularization for severe postpartum haemorrhage.

BACKGROUND To evaluate the fertility and pregnancy outcomes following uterine devascularization for postpartum haemorrhage (PPH). METHODS All patients who required uterine devascularization, i.e. bilateral uterine artery ligation (Group A), and either bilateral utero-ovarian ligament (Group B) or suspensory ligament of ovary ligation (Group C) in cases of persistent haemorrhage, for PPH with no concomitant procedures from December 1997 to March 2004 were included. Data were retrieved from medical files and telephone interviews. RESULTS Data were available for 32 of the 40 (80%) patients included in the study. All patients but 4 had a return to normal menses. Postpartum amenorrhea was secondary to ovarian failure in two cases, and synechiae or necrotic uterus each in one case. These four patients belonged to Group C, whereas no adverse events were observed in groups A and B. Thirteen patients had 16 pregnancies with 13 term deliveries, 1 ectopic pregnancy and 2 abortions. Clinical course of the 13 complete gestations were uneventful but PPH recurred in 4 (31%) due to placenta accreta in three cases. CONCLUSIONS Uterine artery ligation, whether or not associated with utero-ovarian ligament ligation, for PPH does not appear to compromise the patients' subsequent fertility and obstetrical outcome.
[Experimental study on different power CO2 laser for vocal cord injury].

OBJECTIVE To observe the injury and repair of the subepithelial cordectomy by CO2 laser in different power. METHODS Thirty dogs were randomly divided into 5 groups according to different laser power such as A(1 W), B(3 W), C(5 W), D(8 W), E(cold instruments), 6 dogs in each group. Subepithelial cordectomy was performed on the dogs and the tissue damage and wound recovery were observed in different time after operation. RESULTS The mucosa reaction in group C, D was heavier than those in group A, B, E, and the wounds healed slowly with visible pathological scars. The densities of fibroblast and blood capillary were determined with optical microscope. It was found that those in group C, D were higher than those in group A, B, E. The difference was statistically significant (average P < 0.05). Observation by electron microscope showed that the injuries were lighter in group A, B, E and there was no significant difference in vocal cord repair process, while the injuries were more serious in group C, D with few elastic fibers in lamina propria and collagen fibers increased significantly after vocal cord repairing. CONCLUSIONS The tissue repair after subepithelial cordectomy by CO2 laser with low power (1 - 3 W) was similar to that by cold instrument surgery.
[Prevalence of Chlamydia and Neisseria gonorrhoeae infections in pregnant women in six Brazilian cities].

PURPOSE This paper has aimed at estimating the prevalence of infections by Chlamydia trachomatis and by Neisseria gonorrhoeae in pregnant women from six Brazilian cities, identifying its association with socio-economical and demographic variables. METHODS This study has been part of a multicentric nationwide transversal research, with samples of pregnant women attended from 2004 to 2005 in basic attention pre-natal services from six Brazilian cities (Manaus, Fortaleza, Goiânia, Rio de Janeiro, São Paulo and Porto Alegre). Cervico-vaginal samples have been collected from all the pregnant women, and have afterwards been submitted to the hybrid capture technique in order to identify chlamydia and gonococcus. Socio-demographic, medical, sexual and obstetric information have been collected through specific questionnaires. The Odds Ratio (OR) has been used to evaluate risk factors associated to infection by gonorrhea and chlamydia. Statistical analysis has been done with the t-Student, chi2 and Fisher's exact tests. RESULTS Three thousand and three pregnant women with an average age of 23.8 years old (+/-6.9) took part in the study. Infection prevalence by chlamydia and gonococcus were 9.4 and 1.5, respectively. Ten per cent of the pregnant women with chlamydia have presented gonococcus simultaneously. The risk of presenting one of those infections was two times higher for the women under 20. The infection main predictors have been: age under 20, race/black, single/separated and report of over one partner in the previous year. CONCLUSIONS This study has observed high prevalence of infection by Chlamydia trachomatis and by Neisseria gonorrhoeae in Brazilian pregnant women. The main risk factor for the infection has been to be under 20 years old.
Maculopathy in uveitis of juvenile idiopathic arthritis: an optical coherence tomography study

Aim: The aim of this study was to examine the frequency and characteristics of macular lesions observed in juvenile idiopathic arthritis (JIA) uveitis, using optical coherence tomography (OCT). Methods: In this cross-sectional study, 38 consecutive patients were recruited from a tertiary referral center in uveitis. All eyes with JIA uveitis underwent complete ophthalmic examination including OCT 3. Exclusion criterion was the inability to obtain OCT scans. Flare and visual acuity were also analysed by using linear regression. Results: We analysed foveal thickness (FT) and central foveal thickness (CFT), using software mapping, to describe macular lesions in 61 eyes. Maculopathy was observed in 51 eyes (84%) compared with 12% in the literature (p<0.0001) and comprised four types: perifoveolar thickening in 45 eyes (74%), macular oedema in 29 eyes (48%), foveal detachment in 11 eyes (18%) and atrophic changes in six eyes (10%). Only four eyes did not demonstrate any lesion. Conclusions: Among children with JIA uveitis, macular involvement is frequent and characterised by perifoveolar thickening and serous retinal detachment. OCT is a non-invasive instrument. It can easily identify this maculopathy, which could impair visual function, and require therapeutic intensification.
High-Throughput Sequencing Detects Minimal Residual Disease in Acute T Lymphoblastic Leukemia

High-throughput sequencing can detect minimal residual disease comparable to multiparametric flow cytometry in T-ALL patients. Finding a Needle in a Haystack Even in seemingly successful cancer therapy, a small number of cells can survive treatment and persist in patients in remission. This minimal residual disease (MRD) is a major cause of cancer relapse, and until recently was undetectable. New ways to track MRD can determine whether cancer has been eradicated, compare the efficacy of different treatments, monitor patient remission status, and aid in treatment selection. Wu et al. use high-throughput sequencing (HTS) of lymphoid receptor genes to track MRD in T-lineage acute lymphoblastic leukemia/lymphoma (T-ALL). The authors sequence the variable regions of two T cell antigen receptor genes (TCRB and TCRG) using multiplexed polymerase chain reaction. First, they identified clonal T cell receptor (TCR) sequences in individual T-ALL patients and then looked in the same patients after treatment. Their strategy identified clonality at diagnosis in most cases and also detected subsequent MRD. In a subset of cases, HTS detected MRD in patients where it was not detected by flow cytometry, which is currently used in the clinic. Thus, HTS may lower the threshold of detection for MRD and affect treatment decisions. High-throughput sequencing (HTS) of lymphoid receptor genes is an emerging technology that can comprehensively assess the diversity of the immune system. Here, we applied HTS to the diagnosis of T-lineage acute lymphoblastic leukemia/lymphoma. Using 43 paired patient samples, we then assessed minimal residual disease (MRD) at day 29 after treatment. The variable regions of TCRB and TCRG were sequenced using an Illumina HiSeq platform after performance of multiplexed polymerase chain reaction, which targeted all potential V-J rearrangement combinations. Pretreatment samples were used to define clonal T cell receptor (TCR) complementarity-determining region 3 (CDR3) sequences, and paired posttreatment samples were evaluated for MRD. Abnormal T lymphoblast identification by multiparametric flow cytometry was concurrently performed for comparison. We found that TCRB and TCRG HTS not only identified clonality at diagnosis in most cases (31 of 43 for TCRB and 27 of 43 for TCRG) but also detected subsequent MRD. As expected, HTS of TCRB and TCRG identified MRD that was not detected by flow cytometry in a subset of cases (25 of 35 HTS compared with 13 of 35, respectively), which highlights the potential of this technology to define lower detection thresholds for MRD that could affect clinical treatment decisions. Thus, next-generation sequencing of lymphoid receptor gene repertoire may improve clinical diagnosis and subsequent MRD monitoring of lymphoproliferative disorders.
A Parallel Distributive Join Algorithm for Cube-Connected Multiprocessors

This paper presents a parallel distributive join algorithm for cube-connected multiprocessors. The performance analysis shows that the proposed algorithm has an almost linear speedup over the sequential distributive join algorithm as the number of processors increases, and its performance is comparable to that of the parallel hybrid-hash join algorithm. A big advantage of the proposed algorithm over hash-based join algorithms is that it does not have the bucket overflow problem caused by nonuniform hashing of the smaller operand relation. Moreover, the proposed algorithm can easily support the nonequijoin operation, which is very hard to implement by using hash-based join algorithms.
Efficacy and Safety of Angiotensin II Type 1 Receptor Blocker/Calcium Channel Blocker Combination Therapy for Hypertension: Focus on a Single-Pill Fixed-Dose Combination of Valsartan and Amlodipine

Adequate lowering of blood pressure reduces the risk of hypertension-induced cardiovascular events. Worldwide, blood pressure is not optimally controlled and more effective management is needed. The efficacy and tolerability of angiotensin II type 1 receptor blockers (ARBs) have led to their widespread use. Calcium channel blockers (CCBs) are highly effective antihypertensives and amlodipine has a long half-life in the circulation. The combination of an ARB with a CCB as a single-pill, fixed-dose treatment is emerging as possibly the best therapy for preventing cardiovascular disease. Although many kinds of ARB are used in such combinations, amlodipine is mainly used as the CCB. Thus, differences in safety and efficacy among single-pill ARB/CCBs depend mainly on the ARB. Not all ARBs have the same effects and some of these may be molecular (or differential) rather than class (or common) effects. This review discusses the safety and efficacy of ARB/CCB combination therapy, with particular focus on a single-pill, fixed-dose combination of valsartan/amlodipine.
Effect of Nutrient Intake and Helicobacter pylori Infection on Gastric Cancer in Korea: A Case-Control Study

Abstract: To examine the effects of dietary factor and Helicobacter pylori (H. pylori) infection with emphasis on vitamin intake on the risk of gastric cancer (GC), we conducted a case-control study in South Korea, a high-risk area for GC. Trained dietitians interviewed 136 cases histologically diagnosed with GC. An equal number of hospital controls was selected by matching sex and age. High dietary intakes of vegetable fat [odds ratio (OR) = 0.35; 95% confidence interval (CI) = 0.15-0.83], folate (OR = 0.35; 95% CI = 0.13-0.96), and antioxidants, such as vitamin A (OR = 0.34; 95% CI = 0.13-0.83), β-carotene (OR = 0.33; 95% CI = 0.13-0.82), vitamin C (OR = 0.26; 95% CI = 0.09-0.72), and vitamin E (OR = 0.41; 95% CI = 0.17-1.01), were shown to have a protective effect on GC risk using a multivariate model adjusting for foods significantly related to GC in our previous study (charcoal grilled beef, spinach, garlic, mushroom, and a number of types of kimchi) and supplement use. When stratified according to H. pylori infection, high intakes of vitamin C (OR = 0.10; 95% CI = 0.02-0.63) and vitamin E (OR = 0.16; 95% CI = 0.03-0.83) exhibited highly significant inverse associations with GC among the H. pylori-infected subjects compared with noninfected individuals. GC risk was significantly decreased only when consumption levels for two of these vitamins were high. Our findings suggest that high intake of antioxidant vitamins contribute to the reduction of GC risk and that GC risk in Korea may be decreased by encouraging those with H. pylori infection to increase their intake of antioxidant vitamins.
Novel Hydrophobin Fusion Tags for Plant-Produced Fusion Proteins

Hydrophobin fusion technology has been applied in the expression of several recombinant proteins in plants. Until now, the technology has relied exclusively on the Trichoderma reesei hydrophobin HFBI. We screened eight novel hydrophobin tags, T. reesei HFBII, HFBIII, HFBIV, HFBV, HFBVI and Fusarium verticillioides derived HYD3, HYD4 and HYD5, for production of fusion proteins in plants and purification by two-phase separation. To study the properties of the hydrophobins, we used N-terminal and C-terminal GFP as a fusion partner. Transient expression of the hydrophobin fusions in Nicotiana benthamiana revealed large variability in accumulation levels, which was also reflected in formation of protein bodies. In two-phase separations, only HFBII and HFBIV were able to concentrate GFP into the surfactant phase from a plant extract. The separation efficiency of both tags was comparable to HFBI. When the accumulation was tested side by side, HFBII-GFP gave a better yield than HFBI-GFP, while the yield of HFBIV-GFP remained lower. Thus we present here two alternatives for HFBI as functional fusion tags for plant-based protein production and first step purification.