Miracle-dz/UniFAR-FTUs huggingface dataset:
Tibiofemoral Kinematics of the Anterior Cruciate Ligament (ACL)-Deficient Weightbearing, Living Knee Employing Vertical Access Open “Interventional” Multiple Resonance Imaging

Background Our current understanding of tibiofemoral kinematics in the anterior cruciate ligament (ACL)-deficient knee is very limited. Using vertical open-access MRI, it is possible to accurately analyze tibiofemoral motion in patients with isolated rupture of the ACL. Study Prospective cohort study. Purpose To assess if ACL rupture alters normal knee weightbearing kinematics. Methods Tibiofemoral motion was assessed through the arc of flexion from 0 ° to 90 ° in 10 patients with isolated rupture of the ACL in one knee and a normal contralateral knee. Midmedial and midlateral sagittal images were analyzed in all positions of flexion in both knees to assess the tibiofemoral relationship. Results In the lateral compartment of the knee, the tibial plateau is persistently subluxed anteriorly throughout the arc of flexion from 0 ° to 90 ° (flexion facet center to posterior tibial cortex distance of 15.8 mm ± 2.9 in ACL-deficient knees compared to 21.4 mm ± 1.4 in normal knees at 0 ° extension, P< .0001) when compared to normal knees. The medial tibiofemoral relationship is unchanged compared to normal knees. Conclusion Rupture of the ACL changes tibiofemoral kinematics producing anterior subluxation of the lateral tibial plateau. Clinical Significance Altered kinematics may explain, at least in part, the increased incidence of secondary osteoarthritis in patients with ACL rupture.
Who, when, and where? Age-related differences on a new memory test

Our study examined age-related differences on a new memory test assessing memory for “who,” “when,” and “where,” and associations among these elements. Participants were required to remember a sequence of pictures of different faces paired with different places. Older adults remembered significantly fewer correct face–place pairs in the correct sequence compared with young adults. Correlation analyses with standardized neuropsychological tests provide preliminary evidence for construct validity. Our results offer insight into age-related changes in the ability to remember associations between people and places at different points in time using a portable test that can be administered rapidly in various settings.
ICF profiling of patients with traumatic brain injury: an international professional survey

Abstract Purpose: A worldwide internet survey was conducted (1) to identify problems of individuals with traumatic brain injury (TBI) addressed by health professionals and (2) to summarize these problems using the International Classification of Functioning, Disability and Health (ICF). Method: A pool of professionals involved in the TBI rehabilitation process that included physicians, nurses, physical therapists, occupational therapists, social workers and psychologists were surveyed to identify problems in functioning and contextual factors of individuals with TBI using open-ended questions. All answers were translated (“linked”) to the ICF based on established rules. The frequencies of the linked ICF categories were reported stratified based on context. Results: One-hundred thirty seven professionals from the six World Health Organization regions identified 5656 concepts. 92.66% could be linked to the ICF; 33.03% were related to the domain of body functions, 27.28% to activities and participation, 10.98% to structures and 21.38% to environmental factors. Conclusions: The complexity of TBI was described through the identification of a wide variety of ICF categories. ICF language proved to be a neutral framework allowing the comparison of answers between different professionals in different world regions. Implications for Rehabilitation People that suffered a traumatic brain injury (TBI) may have a variety of sequelae that impair functioning. The International Classification of Functioning, Disability and Health (ICF) can help in providing information regarding the identification of patients problems and needs as well as planning, implementing and coordinating the rehabilitation process. The ICF provides a frame of reference process illustrated as the rehabilitation cycle that can help during the rehabilitation process in goal setting bringing together the clinicians’ and patient’s perspectives in a patient oriented biopsychosocial approach. In the field of TBI rehabilitation, activity limitations and participation restrictions are broadly affected as reported by the professionals interviewed and highly influenced by cognitive and moreover behavioral problems.
Genetics of Dupuytren ' s disease The basics of genetic inheritance

It was first recognised in 1833 that there was an inherited predisposition to Dupuytren’s Disease, before DNA and genes were discovered (1). Since then, hand surgeons have continued to be fascinated by the nature and extent of this predisposition. As epidemiological methodology and molecular genetic techniques have developed, our understanding has advanced, such that the design of novel therapeutic interventions based on this knowledge is becoming a realistic possibility. In this section, we begin by briefly reviewing important principles and concepts of genetic inheritance. We then assess the evidence for a genetic predisposition to Dupuytren’s Disease. Next we consider the molecular genetic studies that have helped define the magnitude and nature of that genetic predisposition. Finally, we consider potential future developments in this fast developing field. Genetics of Dupuytren's disease The basics of genetic inheritance
Altered mitochondrial regulation in quadriceps muscles of patients with COPD

Evidence exists for locomotor muscle impairment in patients with chronic obstructive pulmonary disease (COPD), including fiber type alterations and reduced mitochondrial oxidative capacity. In this study high‐resolution respirometry was used to quantify oxygen flux in permeabilized fibres from biopsies of the vastus lateralis muscle in patients with COPD and compared to healthy control subjects. The main findings of this study were that (i) routine state 2 respiration was higher in COPD; (ii) state 3 respiration in the presence of ADP was similar in both groups with substrate supply of electrons to complex I (COPD 38·28 ± 3·58 versus control 42·85 ± 3·10 pmol s−1 mg tissue−1), but O2 flux with addition of succinate was lower in COPD patients (COPD 63·72 ± 6·33 versus control 95·73 ± 6·53 pmol s−1 mg tissue−1); (iii) excess capacity of cytochrome c oxidase in COPD patients was only ∼50% that of control subjects. These results indicate that quadriceps muscle mitochondrial function is altered in patients with COPD. The regulatory mechanisms underlying these functional abnormalities remain to be uncovered.
MACROGEOGRAPHIC VARIATION IN LITTER SIZE IN ANTECHINUS (MARSUPIALIA: DASYURIDAE)

The best documented cases of geographic variation in brood size are the tendency of avian clutches to increase with latitude (Lack, 1947, 1954; Klomp, 1970), and mammalian litters to increase with both latitude (Lord, 1960), and altitude (Dunmire, 1960; Fleming and Rauscher, 1978; Bronson, 1979). There is no consensus on the cause of this phenomenon (Stearns, 1976; Ricklefs, 1980). Lack (1947) proposed that parents produce broods which correspond with the maximum number of young they can nourish. Numerous modifications to this hypothesis have been suggested (Ashmole, 1963; Cody, 1966; Owen, 1977; Hogstedt, 1980), and a number of theoretical models have been developed that suggest brood size should be reduced below the most productive size (Stearns, 1976). Two classes with wide application can be recognized among the latter models. The first includes those based on the tradeoff between fecundity and adult mortality resulting from increased reproductive effort (Charnov and Krebs, 1974). According to this approach adults should limit the size of their brood in certain environments to extend their opportunities of breeding again (Ricklefs, 1977a). This viewpoint has been criticized because it fails to predict what size smaller broods should be to ensure iteroparous reproduction (Ricklefs, 1977b). The second includes those models which predict tradeoffs between demands for resources on the part of reproduction and other functions, particularly avoidance of predation (Cody, 1966; Skutch, 1967; Perrins, 1977). Ricklefs (1977a) presented evidence that predation is not sufficiently important to account for the magnitude of variation commonly observed along geographic gradients. Several methodological difficulties have hindered investigation of these hypotheses. The genetic basis of variation in brood size has rarely been established (Krohne, 1980, 1981). Further, the influence of predation and the proposed trade-off between reduced clutch size and increased adult longevity have been difficult to quantify in field populations. While it is possible to distinguish between semelparous and iteroparous species, an index of the extent of iteroparity remains elusive and is confounded by difficulties in ageing wild individuals and the production of more than one brood within a season. A study of variation in brood size within semelparous species might be informative, but brood sizes in semelparous invertebrates and lower vertebrates and monocarpic plants are enormous and difficult to quantify. In this study we report macrogeographic variation in the litter size of Antechinus, a genus of mammals in which the frequency of iteroparous versus semelparous reproduction can be precisely quantified, and in which we believe litter size differences are genetically determined. Litter size is manageably low and variable (6-13), and only one litter is produced each year. This combination of characters provides a tractable system for resolution of the separate factors which might influence litter size.
Ultrastructural alterations of pancreatic beta cells in human diabetes mellitus

Both types of diabetes are characterized by beta‐cell failure and death, leading to insulin insufficiency. Very limited information is currently available about the ultrastructural alterations of beta cells in human diabetes. Our aim was to provide a comprehensive ultrastructural analysis of human pancreatic islets in type 1 (T1D) and type 2 (T2D) diabetic patients.
Impact of Medication Adherence on the Effect of Renal Denervation: The SYMPATHY Trial

Randomized trials of catheter-based renal denervation (RDN) as therapy for resistant hypertension showed conflicting results in blood pressure (BP) lowering effect. Adherence to medication is modest in this patient group and may importantly drive these conflicting results. SYMPATHY is a prospective open label multicenter trial in Dutch patients with resistant hypertension. Primary outcome was change in daytime systolic ambulatory BP at 6 months. Patients were randomly assigned to RDN on top of usual care. Adherence to BP lowering drugs was assessed at baseline and follow-up, using blood samples drawn synchronously with BP measurements. Patients and physicians were unaware of the adherence assessment. Primary analyses showed a mean difference between RDN (n=95) and control (n=44) in changes in daytime systolic ambulatory BP after 6 months of 2.0 mm Hg (95% confidence interval, −6.1 to 10.2 mm Hg) in favor of control. In 80% of patients, fewer medications were detected than prescribed and adherence changed during follow-up in 31%. In those with stable adherence during follow-up, mean difference between RDN and control for daytime systolic ambulatory BP was −3.3 mm Hg (−13.7 to 7.2 mm Hg) in favor of RDN. RDN as therapy for resistant hypertension was not superior to usual care. Objective assessment of medication use shows that medication adherence is extremely poor, when patients are unaware of monitoring. Changes over time in adherence are common and affect treatment estimates considerably. Objective measurement of medication adherence during follow-up is strongly recommended in randomized trials. Clinical Trial Registration— URL: http://www.clinicaltrials. gov. Unique identifier: NCT01850901.
The Development of a Liver Abscess after Screening Colonoscopy: A Calculated Risk?

We present the case of a patient who developed a liver abscess following screening colonoscopy. A colorectal screening program was introduced in the Netherlands in 2014 in order to reduce mortality from colorectal cancer. The patient in this report, a 63-year-old man with no significant medical history, underwent polypectomy of two polyps. Four days afterwards he presented to our emergency department with fever, nausea and vomiting. He was diagnosed with a Klebsiella pneumoniae liver abscess and was successfully treated with antibiotics for 6 weeks. This case highlights one of the risks of screening colonoscopy. Given the high number of colonoscopies due to the colorectal screening programs, we should be aware of complications in this mostly asymptomatic group of patients. LEARNING POINTS Screening colonoscopy is a potential risk factor for Klebsiella pneumoniae liver abscess. It is thought that microperforations during colonoscopy could lead to bacterial invasion causing a pyogenic liver abscess. We expect the numbers of complications, including pyogenic liver abscess, to grow due to the increase in population-based screening programs for colorectal carcinoma.
A Dominant Negative Mutant of Pma1 Interferes with the Folding of the Wild Type Enzyme

Misfolded proteins are usually arrested in the endoplasmic reticulum (ER) and degraded by the ER‐associated degradation (ERAD) machinery. Several mutant alleles of PMA1, the gene coding for the plasma membrane H +‐ATPase, render misfolded proteins that are subjected to ERAD. A subset of misfolded PMA1 mutants exhibits a dominant negative effect on yeast growth since, when co‐expressed with the wild type allele, both proteins are retained in the ER and degraded. We have used a PMA1‐D378T dominant lethal allele to analyse the mechanism underlying the retention of the wild type enzyme by the dominant negative mutant. A genetic screen was performed for isolation of intragenic suppressors of PMA1‐D378T allele. This analysis pointed to transmembrane helix 10 (TM10) as an important element in the establishment of the dominant lethality. Deletion of the TM10 was able to suppress not only the PMA1‐D378T but all the dominant lethal alleles tested. Biochemical analyses suggest that dominant lethal proteins obstruct, through TM10, the correct folding of the wild type enzyme leading to its retention and degradation by ERAD.
Differentiation of the XY Sex Chromosomes in the Fish Hoplias malabaricus (Characiformes, Erythrinidae): Unusual Accumulation of Repetitive Sequences on the X Chromosome

The wolf fish Hoplias malabaricus (Erythrinidae) presents a high karyotypic diversity, with 7 karyomorphs identified. Karyomorph A is characterized by 2n = 42 chromosomes, without morphologically differentiated sex chromosomes. Karyomorph B also has 2n = 42 chromosomes for both sexes, but differs by a distinct heteromorphic XX/XY sex chromosome system. The cytogenetic mapping of 5 classes of repetitive DNA indicated similarities between both karyomorphs and the probable derivation of the XY chromosomes from pair No. 21 of karyomorph A. These chromosomes appear to be homeologous since the distribution of (GATA)n sequences, 18S rDNA and 5SHindIII-DNA sites supports their potential relatedness. Our data indicate that the differentiation of the long arms of the X chromosome occurred by accumulation of heterochromatin and 18S rDNA cistrons from the ancestral homomorphic pair No. 21 present in karyomorph A. These findings are further supported by the distribution of the Cot-1 DNA fraction. In addition, while the 18S rDNA cistrons were maintained and amplified on the X chromosomes, they were lost in the Y chromosome. The X chromosome was a clearly preferred site for the accumulation of DNA repeats, representing an unusual example of an X clustering more repetitive sequences than the Y during sex chromosome differentiation in fish.
! Title : Within and across-trial dynamics of human EEG reveal cooperative interplay between reinforcement learning and working memory

Learning from rewards and punishments is essential to survival, and facilitates flexible human behavior. It is widely appreciated that multiple cognitive and reinforcement learning systems contribute to behavior, but the nature of their interactions is elusive. Here, we leverage novel methods for extracting trial-by-trial indices of reinforcement learning (RL) and working memory (WM) in human electroencephalography to reveal single trial computations beyond that afforded by behavior alone. Within-trial dynamics confirmed that increases in neural expectation were predictive of reduced neural surprise in the following feedback period, supporting central tenets of RL models. Cross-trial dynamics revealed a cooperative interplay between systems for learning, in which WM contributes expectations to guide RL, despite competition between systems during choice. Together, these results provide a deeper understanding of how multiple neural systems interact for learning and decision making, and facilitate analysis of their disruption in clinical populations. CC-BY-NC-ND 4.0 International license peer-reviewed) is the author/funder. It is made available under a The copyright holder for this preprint (which was not . http://dx.doi. org/10.1101/184812 doi: bioRxiv preprint first posted online Sep. 5, 2017;
The CSC proteins FAP61 and FAP251 build the basal substructures of radial spoke 3 in cilia

Motile cilia have nine doublet microtubules, with hundreds of associated proteins that repeat in modules. Each module contains three radial spokes, which differ in their architecture, protein composition, and function. The conserved proteins FAP61 and FAP251 are crucial for the assembly and stable docking of RS3 and cilia motility.
Improvement in sexual functioning in patients with interstitial cystitis/painful bladder syndrome.

INTRODUCTION Sexual functioning is one of the strongest predictors of poorer quality of life (QOL) in patients diagnosed with interstitial cystitis/painful bladder syndrome (IC/PBS). AIMS To examine the relationship between symptom reduction and sexual functioning in patients with IC/PBS. METHODS Patients with IC/PBS were treated with 300 mg/day pentosan polysulfate sodium for 32 weeks. MAIN OUTCOME MEASURES Patients completed the O'Leary-Sant Interstitial Cystitis Symptom Index, Short Form-12 QOL, and Medical Outcomes Study Sexual Functioning Scale at baseline, and at 8, 16, 24, and 32 weeks. Treatment responders were defined as those achieving a >/=30% reduction in symptom index from baseline. RESULTS A total of 128 patients were included in the analyses. At baseline, mean symptom index, QOL (physical and mental), and sexual functioning scores were 12.3, 41.7, 45.9, and 56.1, respectively. Patients showed statistically significant improvement in symptom and sexual functioning scores at weeks 8, 16, 24, and 32. At week 32, the mean change in symptom index score from baseline was -2.97 (standard deviation [SD] = 4.66, P < 0.0001), and the mean change in sexual functioning score from baseline was 8.9 (SD = 32.9, P = 0.0054). Reduction in symptom index score was moderately correlated with improvement in sexual functioning score at the end of study (r = -35, P = 0.0002). Positive correlation was observed at the end of the study between the mean change scores of sexual functioning score and physical and mental QOL components (r = 0.46, P < 0.0001 and r = 0.29, P = 0.0023, respectively). Patients achieving a >/=30% reduction in symptom index (responder, N = 47; 44%) had an adjusted mean change in sexual functioning score of 19.8 (standard error [SE] = 4.69), while nonresponders (N = 59, 56%) had an adjusted mean change -0.49 (SE = 4.17) (between groups, P = 0.0020). CONCLUSIONS Sexual dysfunction is moderate to severe in patients with IC/PBS and impacts significantly on QOL. Reduction in symptoms was associated with improvement in the patient-reported outcomes of sexual function.
Elevated risk profile of women in secondary prevention of coronary artery disease: a 6-year survey of 117,913 patients.

BACKGROUND AND AIMS The prognosis of female patients after acute coronary syndrome (ACS) has been shown to be inferior to that of male patients. Little is known about gender differences during the secondary prevention phase. METHODS After ACS, 117,913 patients (30.7% female) were enrolled in two large-scale German registries from 2000 to 2005 during phase II cardiac rehabilitation (CR). Demographic parameters, reperfusion strategies, cardiovascular risk factors, exercise capacity, and medication use at admission and discharge were assessed. Temporary changes (trends) and gender-specific differences were determined. RESULTS Compared to 2000, patients in 2005 were significantly older (females: 66.4 vs. 68.0 years; males: 62.3 vs. 63.3 years; p = 0.001) and had a higher body mass index (BMI) (females: 27.7 vs. 28.6 kg/m(2); males: 27.6 vs. 28.1 kg/m(2), in 2000 and 2005, respectively, p < 0.001). Target blood pressure <140/90 mm Hg at discharge was obtained in a smaller proportion of women than men (81.0 vs. 83.0%, p < 0.001). Low-density lipoprotein cholesterol (LDL-C) levels at discharge were significantly higher in female patients (95.0 vs. 93.2 mg/dL, p < 0.001); 80.9% of female vs. 83.8% of male patients achieved a target fasting glucose <126 mg/dL during the CR (p < 0.001). Large between-center variability was noted for age, total cholesterol at entry, and exercise capacity at entry and discharge. CONCLUSIONS Although control of cardiovascular risk factors has improved in both genders, over a recent 6-year period, female patients compared with males were less likely to achieve target values for blood pressure, fasting glucose, and lipid values in the early period after acute coronary events.
Risk and Outbreak Communication: Lessons from Taiwan's Experiences in the Post-SARS Era

In addition to the impact of a disease itself, public reaction could be considered another outbreak to be controlled during an epidemic. Taiwan's experience with SARS in 2003 highlighted the critical role played by the media during crisis communication. After the SARS outbreak, Taiwan's Centers for Disease Control (Taiwan CDC) followed the WHO outbreak communication guidelines on trust, early announcements, transparency, informing the public, and planning, in order to reform its risk communication systems. This article describes the risk communication framework in Taiwan, which has been used to respond to the 2009-2016 influenza epidemics, Ebola in West Africa (2014-16), and MERS-CoV in South Korea (2015) during the post-SARS era. Many communication strategies, ranging from traditional media to social and new media, have been implemented to improve transparency in public communication and promote civic engagement. Taiwan CDC will continue to maintain the strengths of its risk communication systems and resolve challenges as they emerge through active evaluation and monitoring of public opinion to advance Taiwan's capacity in outbreak communication and control. Moreover, Taiwan CDC will continue to implement the IHR (2005) and to promote a global community working together to fight shared risks and to reach the goal of “One World, One Health. ”