Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparison of sirolimus‐eluting stent, paclitaxel‐eluting stent, and bare metal stent in the treatment of long coronary lesions

Objective: This study compared the efficacy of the sirolimus‐eluting stent (SES), the paclitaxel‐eluting stent (PES), and the bare metal stent (BMS) for long coronary lesions. Background: The outcome of drug‐eluting stent (DES) implantation in long coronary lesions remains unclear. Methods: The study involved 527 patients with de novo long coronary lesions (≥24 mm), which were treated with long (≥28 mm) SESs (223 lesions), PESs (194 lesions), or BMSs (201 lesions). Results: Lesions in the SES (36.0 ± 14.9 mm, P < 0.001) and PES (36.3 ± 14.5 mm, P < 0.001) groups were longer than those in the BMS group (32.0 ± 12.3 mm), meaning the two DES groups had longer stented segments than did the BMS group. Six‐month angiographic follow‐up showed the SES (9.3%, P < 0.001) and PES (21.3%, P < 0.001) groups had lower in‐segment restenosis rates than that of the BMS group (42.5%). The rate of major adverse cardiac events (MACE) including death, myocardial infarction, and target lesion revascularization at 9 months was higher in the BMS group (26.6%) than that in the SES (13.0%, P < 0.001) and PES (15.7%, P < 0.001) groups. Posthoc analysis of the two DES groups showed that the in‐segment restenosis rate was lower for the SES than that for the PES group (P = 0.002), while the MACE rate was similar. Conclusions: The use of DESs for long coronary lesions appears to be safe and more effective than the use of BMSs in terms of restenosis and adverse clinical events. SES use was associated with lower late luminal loss and a lower angiographic restenosis rate compared with PES use. © 2006 Wiley‐Liss, Inc.
S‐Nitrosocaptopril: acute in‐vivo pulmonary vasodepressor effects in pulmonary hypertensive rats

The effects of S‐nitrosocaptopril (SNOcap), administered either intravenously or by oral gavage, on pulmonary artery pressure (PAP) were examined in anaesthetised normotensive rats and rats with hypoxic pulmonary hypertension (10% oxygen for 1 week). Mean PAP (MPAP) values in hypoxic and normoxic rats were (mmHg) 26± 1.7 and 15± 1.1, respectively. When given intravenously, 1 mg kg−1 SNOcap reduced MPAP by 28 and 32% in hypoxic and normoxic rats, respectively. The effects of 2 mg kg−1 were no greater than those of 1 mg kg−1. Pulmonary vasodepressor responses reached equilibrium in 1.7$pL0.18 min following intravenous administration. When given orally 30 min before the measurement of PAP, 30 mg kg−1, but not 10 mg kg−1, significantly reduced MPAP in hypoxic rats to 17$pL 1.5 mmHg. These in‐vivo data are consistent with previous in‐vitro data showing that SNOcap has direct pulmonary vasorelaxant properties in both large and small pulmonary arteries and also show that SNOcap causes pulmonary vasodepression in the setting of pulmonary hypertension. Since SNOcap also inhibits pulmonary vascular angiotensin converting enzyme (ACE) in pulmonary blood vessels (previous study), it would be an interesting drug with which to assess the benefits of direct pulmonary vasodilatation combined with ACE inhibition (which attentuates pulmonary vascular remodelling) in a long‐term study in pulmonary hypertension.
Ethnic ancestry and increased paternal age are risk factors for breast cancer before the age of 40 years

To study the risk factors associated with breast cancer in women younger than 40 years, a cohort study (The Jerusalem Perinatal Study) of 42 822 female offspring born in hospitals in West Jerusalem during 1964–1976 was carried out. Hazard ratios of potential parental and perinatal risk factors for early breast cancer were measured. The overall incidence of breast cancer was 5.2/100 000 person–years. The highest incidence was found among Jewish women of West Asian ancestry (8.6/100 000 person–years), specifically those whose maternal grandfathers were born in Iraq, Iran or Afghanistan (9.5/100 000 person–years). Using Cox models we found independent risk factors for early breast cancer to be paternal age (relative risk/year=1.06, 95% confidence interval=1.02–1.10, P=0.005), and ancestry from Iraq/Iran/Afghanistan (relative risk=3.1, 95% confidence interval=1.50–6.52, P=0.002). The study confirms a previously observed effect of advanced paternal age on the occurrence of early breast cancer and identifies a novel population group at increased risk for the disease. The excess risk of early breast cancer associated with ancestry from Iraq, Iran and Afghanistan suggests involvement of genetic determinants, environmental exposures and/or lifestyle factors and mandates further investigation.
Effects of transcutaneous electrical nerve stimulation on motion sickness induced by rotary chair: a crossover study.

OBJECTIVES Motion sickness (MS) is evoked by the conflict among somatosensory, visual, and vestibular input. Some of the MS symptoms and signs are mediated by activation of the autonomic nervous system (ANS). Transcutaneous electrical nerve stimulation (TENS), a maneuver used for pain control, was found to influence cardiovascular responses through ANS reflex, and to enhance motor function, visuospatial abilities, postural control, and cognitive function. The purpose of the present study is to investigate the effects of TENS on MS. SUBJECTS AND DESIGN Fifteen (15) healthy young men participated in a within-subjects crossover study. Each completed four test sessions (control, rotation, TENS, TENS+rotation) in randomized order. Rotary chair (120°/s) combined with pitch movement of the subject's head was used as a model to provoke MS. Whole rotation protocol consisted of 5 1-minute rotations, each separated by a 1-minute rest period. TENS protocol involved simultaneous electrical stimulation of posterior neck and Zusanli acupoint. OUTCOME MEASURES Motion sickness susceptibility was rated on a standardized questionnaire (Motion Sickness Susceptibility Questionnaire). Motion sickness symptoms, blood pressure (BP), skin temperature, heart rate (HR), and heart rate variability (HRV) were measured. Saliva samples were collected to analyze the level of stress markers. Cognitive function was evaluated with d2 test prior to and after MS provocation. RESULTS Spinning by itself significantly decreased task response speed and contraction. MS symptom scores, BP, as well as the sympathetic parameter of HRV increased progressively with MS provocation (p<0.05), but skin temperature decreased (p=0.023). Severity of MS symptoms significantly decreased with TENS intervention (p<0.05). After TENS treatment, subjects were able to concentrate better and showed fewer errors in a cognitive test. Salivary cortisol concentration significant decreased after TENS treatment. CONCLUSIONS Sympathetic activity increased but parasympathetic activity decreased during MS. TENS was effective in reducing MS symptoms as well as alleviating cognitive impairment.
Identification of a tumor suppressor network in T-cell leukemia

Abstract To identify novel cancer-related genes targeted by copy number alterations, we performed genomic profiling of T-cell acute lymphoblastic leukemia (T-ALL) cell lines. In 3/8, we identified a shared deletion at chromosomal position 2p16.3-p21. Within the minimally deleted region, we recognized several candidate tumor suppressor (TS) genes, including FBXO11 and FOXN2. An additional deletion at chromosome 14q23.2-q32.11 included FOXN3, highlighting this class of FOX genes as potential TS. Quantitative expression analyses of FBXO11, FOXN2, and FOXN3 confirmed reduced transcript levels in the identified cell lines. Moreover, reduced expression of these genes was also observed in about 7% of T-ALL patients, showing their clinical relevance in this malignancy. Bioinformatic analyses revealed concurrent reduction of FOXN2 and/or FOXN3 together with homeobox gene ZHX1. Consistently, experiments demonstrated that both FOXN2 and FOXN3 directly activated transcription of ZHX1. Taken together, we identified novel TS genes forming a regulatory network in T-cell development and leukemogenesis.
Safety of efavirenz in the first trimester of pregnancy: an updated systematic review and meta-analysis

Evidence of the risk of birth defects with efavirenz use is limited. We updated a meta-analysis of birth defects in infants with first trimester efavirenz exposure up to July 2011. In 21 studies, there were 39 defects among live births in 1437 women receiving first trimester efavirenz [2.0%, 95% confidence interval (CI) 0.82–3.18]. The relative risk of defects comparing women on efavirenz-based (1290 live births) and nonefavirenz-based regimens (8122 live births) was 0.85 (95% CI 0.61–1.20). One neural tube defect was observed (myelomeningocele), giving an incidence of 0.07% (95% CI 0.002–0.39).
An Academic-Government-Faith Partnership to Build Disaster Mental Health Preparedness and Community Resilience

Objectives. Faculty and affiliates of the Johns Hopkins Preparedness and Emergency Response Research Center partnered with local health departments and faith-based organizations to develop a dual-intervention model of capacity-building for public mental health preparedness and community resilience. Project objectives included (1) determining the feasibility of the tri-partite collaborative concept; (2) designing, delivering, and evaluating psychological first aid (PFA) training and guided preparedness planning (GPP); and (3) documenting preliminary evidence of the sustainability and impact of the model. Methods. We evaluated intervention effectiveness by analyzing pre- and post-training changes in participant responses on knowledge-acquisition tests administered to three urban and four rural community cohorts. Changes in percent of correct items and mean total correct items were evaluated. Criteria for model sustainability and impact were, respectively, observations of non-academic partners engaging in efforts to advance post-project preparedness alliances, and project-attributable changes in preparedness-related practices of local or state governments. Results. The majority (11 of 14) test items addressing technical or practical PFA content showed significant improvement; we observed comparable testing results for GPP training. Government and faith partners developed ideas and tools for sustaining preparedness activities, and numerous project-driven changes in local and state government policies were documented. Conclusions. Results suggest that the model could be an effective approach to promoting public health preparedness and community resilience.
Long-term stability of acute and transient psychotic disorders

Objective: To examine the temporal stability of the category ‘acute and transient psychotic disorders’ (ATPDs), ICD-10 Classification of Mental and Behavioural Disorders, including subtypes characterised by polymorphic, schizophrenic and predominantly delusional features. Method: We checked the readmission patterns of all patients aged 15–64 years (n = 5426), whether admitted to hospital or treated as outpatients, who were enrolled for the first time in the Danish Psychiatric Register with a diagnosis of ATPDs between 1995 and 2008. Results: An increasing number of cases with ATPDs changed diagnosis in subsequent admissions after 1, 2 and 5 years, mainly either to schizophrenia and related disorders or affective disorders. In their last admission, on average after 7.3 years, there were 2429 patients listed with ATPDs, accounting for an overall stability of 44.8%. Females were less likely than males to develop another diagnosis. Among the ATPD subtypes, polymorphic psychotic disorder without schizophrenic symptoms had a higher stability than those featuring schizophrenic or predominantly delusional features. Conclusions: The low diagnostic stability of ATPDs reflects the lack of clearly defining features and argues against their validity as a distinct category.
The glutamate transporters EAAT2 and EAAT3 mediate cysteine uptake in cortical neuron cultures

Cysteine availability is normally the rate‐limiting factor in glutathione synthesis. How neurons obtain cysteine from extracellular space is not well established. Here we used mouse cortical neuron cultures to examine the role of the excitatory amino acid transporters (EAATs) in neuronal cysteine uptake. The cultured neurons expressed both EAAT2 and EAAT3. Cysteine uptake was predominately (> 85%) Na+‐dependent, with an apparent Km of 37 μm. Cysteine uptake was reduced by the EAAT substrates l‐glutamate and l‐aspartate and by synthetic EAAT inhibitors. The non‐selective EAAT inhibitor threo‐β‐hydroxyaspartate had a significantly greater maximal inhibitory effect than did the EAAT2‐selective inhibitor, dihydrokainate, indicating uptake by both EAAT2 and EAAT3. Serine, a substrate of ASC uptake system, had negligible effects on cysteine uptake at 10‐fold excess concentrations. To assess the functional importance of EAAT‐mediated cysteine uptake in neuronal glutathione synthesis, cultures were treated with diethylmaleate to deplete glutathione, then incubated with cysteine in the presence or absence of EAAT inhibitors. Threo‐β‐benzyloxyaspartate and the non‐transportable inhibitor threo‐β‐hydroxyaspartate both inhibited the cysteine‐dependent glutathione synthesis. The findings suggest that neuronal EAAT activity can be a rate‐limiting step for neuronal glutathione synthesis and that the primary function of EAATs expressed by neurons in vivo may be to transport cysteine.
Grasp selection analysis for two-step manipulation tasks

Manipulation tasks are sequential in nature. Grasp selection approaches that take into account the con- straints at each task step are critical, since they allow to both (1) Identify grasps that likely require simple arm motions through the whole task and (2) To discard grasps that, although feasible to achieve at earlier steps, might not be executable at later stages due to goal task constraints. In this paper, we study how to use our previously proposed manipulation metric for tasks in which 2 steps are required (pick-and-place and pouring tasks). Even for such simple tasks, it was not clear how to use the results of applying our metric (or any metric for that matter) to rank all the candidate grasps: Should only the start state be considered, or only the goal, or a combination of both? In order to find an answer, we evaluated the (best) grasps selected by our metric under each of these 3 considerations. Our main conclusion was that for tasks in which the goal state is more constrained (pick-and-place), using a combination of the metric measured at the start and goal states renders better performance when compared with choosing any other candidate grasp, whereas in tasks in which the goal constraints are less rigidly defined, the metric measured at the start state should be mainly considered. We present quantitative results in simulation and validate our approach's practicality with experimental results in our physical robot manipulator, Crichton.
Corneal Transplantation in Disease Affecting Only One Eye: Does It Make a Difference to Habitual Binocular Viewing?

Background Clarity of the transplanted tissue and restoration of visual acuity are the two primary metrics for evaluating the success of corneal transplantation. Participation of the transplanted eye in habitual binocular viewing is seldom evaluated post-operatively. In unilateral corneal disease, the transplanted eye may remain functionally inactive during binocular viewing due to its suboptimal visual acuity and poor image quality, vis-à-vis the healthy fellow eye. Methods and Findings This study prospectively quantified the contribution of the transplanted eye towards habitual binocular viewing in 25 cases with unilateral transplants [40yrs (IQR: 32–42yrs) and 25 age-matched controls [30yrs (25–37yrs)]. Binocular functions including visual field extent, high-contrast logMAR acuity, suppression threshold and stereoacuity were assessed using standard psychophysical paradigms. Optical quality of all eyes was determined from wavefront aberrometry measurements. Binocular visual field expanded by a median 21% (IQR: 18–29%) compared to the monocular field of cases and controls (p = 0.63). Binocular logMAR acuity [0.0 (0.0–0.0)] almost always followed the fellow eye’s acuity [0.00 (0.00 –-0.02)] (r = 0.82), independent of the transplanted eye’s acuity [0.34 (0.2–0.5)] (r = 0.04). Suppression threshold and stereoacuity were poorer in cases [30.1% (13.5–44.3%); 620.8arc sec (370.3–988.2arc sec)] than in controls [79% (63.5–100%); 16.3arc sec (10.6–25.5arc sec)] (p<0.001). Higher-order wavefront aberrations of the transplanted eye [0.34μ (0.21–0.51μ)] were higher than the fellow eye [0.07μ (0.05–0.11μ)] (p<0.001) and their reduction with RGP contact lenses [0.09μ (0.08–0.12μ)] significantly improved the suppression threshold [65% (50–72%)] and stereoacuity [56.6arc sec (47.7–181.6arc sec)] (p<0.001). Conclusions In unilateral corneal disease, the transplanted eye does participate in gross binocular viewing but offers limited support to fine levels of binocularity. Improvement in the transplanted eye’s optics enhances its participation in binocular viewing. Current metrics of this treatment success can expand to include measures of binocularity to assess the functional benefit of the transplantation process in unilateral corneal disease.
Molecular Localization of a Redox-Modulated Process Regulating Plant Mitochondrial Electron Transport

Using in organellar assays, we found that significant tobacco alternative oxidase (AOX) activity is dependent on both reduction of a putative regulatory disulfide bond and the presence of pyruvate, which may interact with a Cys sulfhydryl. This redox modulation and pyruvate activation thus may be important in determining the partitioning of electrons to AOX in vivo. To investigate these regulatory mechanisms, we generated tobacco plants expressing mutated AOX proteins. Mutation of the most N-terminal Cys residue (Cys-126) to an Ala residue produced an AOX that could not be converted to the disulfide-linked form, thus identifying this Cys residue as being responsible for redox modulation. Although this mutation might be expected to produce an AOX with constitutive high activity in the presence of pyruvate, we found it to have minimal in organellar activity in the presence of pyruvate. Nonetheless, the Cys-126 mutation did not appear to have compromised the catalytic function of AOX, given that cells expressing the protein displayed high rates of cyanide-resistant respiration in vivo. The striking difference between in vivo and in organellar results suggests that an additional mechanism(s), as yet unidentified by in organellar assays, may promote activity in vivo. Mutation of the Cys residue nearest the presumptive active site (Cys-176) to an Ala residue did not prevent disulfide bond formation or affect the ability of AOX to be stimulated by pyruvate, indicating that this Cys residue is involved in neither redox modulation nor pyruvate activation.
Antibody to the gp120 V1/V2 Loops and CD4+ and CD8+ T Cell Responses in Protection from SIVmac251 Vaginal Acquisition and Persistent Viremia

The human papillomavirus pseudovirions (HPV-PsVs) approach is an effective gene-delivery system that can prime or boost an immune response in the vaginal tract of nonhuman primates and mice. Intravaginal vaccination with HPV-PsVs expressing SIV genes, combined with an i.m. gp120 protein injection, induced humoral and cellular SIV-specific responses in macaques. Priming systemic immune responses with i.m. immunization with ALVAC-SIV vaccines, followed by intravaginal HPV-PsV–SIV/gp120 boosting, expanded and/or recruited T cells in the female genital tract. Using a stringent repeated low-dose intravaginal challenge with the highly pathogenic SIVmac251, we show that although these regimens did not demonstrate significant protection from virus acquisition, they provided control of viremia in a number of animals. High-avidity Ab responses to the envelope gp120 V1/V2 region correlated with delayed SIVmac251 acquisition, whereas virus levels in mucosal tissues were inversely correlated with antienvelope CD4+ T cell responses. CD8+ T cell depletion in animals with controlled viremia caused an increase in tissue virus load in some animals, suggesting a role for CD8+ T cells in virus control. This study highlights the importance of CD8+ cells and antienvelope CD4+ T cells in curtailing virus replication and antienvelope V1/V2 Abs in preventing SIVmac251 acquisition.
An Integrated Treatability Protocol for Biotreatment/Bioremediation of Toxic Pollutants Generated by Chemical Industries

Abstract To optimize the efficiency of bioremediation, treatability studies are needed to understand the fate of pollutants and environmental conditions under which microorganism growth is promoted and efficient degradation of these pollutants result. This article presents a recommended procedure which may achieve these goals. Results and treatability comparisons for candidate compounds including carbon tetrachloride (CT), methyl-tert-butyl-ether (MTBE) and hexachlorobutadiene (HCBD) are presented and discussed. Culture redox potential (ORP) which is an indicator or free electron activity of a system appeared to have a significant impact on CT biodegradation. Optimum biodegradation of CT by Pseudomonas cepacia was observed between −100 and −200 mv. Under the optimum environmental conditions established during the batch-scale biotransformation study, 98 to 99.9% of CT and 70% of MTBE introduced into the continuous fixed-biofilm reactor were degraded. The biphasic model simulating biodegradation of CT and MTBE provided an excellent correlation in the fixed-biofilm study and was simple to apply as compared with other models.
Theoretical Investigation of Trigate AlGaN/GaN HEMTs

The operation of AlGaN/GaN trigate high-electron mobility transistor (HEMT) structures is investigated by numerical simulations. It is shown that the threshold voltage of such structures strongly depends on the width of the AlGaN/GaN bodies and that solely by decreasing the body width a transition from normally-on to normally-off operation can be achieved. Furthermore, the impact of uncertain device and/or material parameters such as strain relaxation, Schottky barrier heights, and dielectric constants on the threshold voltage is studied as well as the influence of the AlGaN barrier design (Al content, thickness). The results of this paper show that the trigate concept is a viable option to realize normally-off AlGaN/GaN HEMTs.
Just-Right Consistency: reconciling availability and safety

By the CAP Theorem, a distributed data storage system can ensure either Consistency under Partition (CP) or Availability under Partition (AP), but not both. This has led to a split between CP databases, in which updates are synchronous, and AP databases, where they are asynchronous. However, there is no inherent reason to treat all updates identically: simply, the system should be as available as possible, and synchronised just enough for the application to be correct. We offer a principled \emph{Just-Right Consistency} approach to designing such applications, reconciling correctness with availability and performance, based on the following insights:(i) The Conflict-Free Replicated Data Type (CRDTs) data model supports asynchronous updates in an intuitive and principled way. (ii) Invariants involving joint or mutually-ordered updates are compatible with AP and can be guaranteed by Transactional Causal Consistency, the strongest consistency model that does not compromise availability. Regarding the remaining, ``CAP-sensitive'' invariants:(iii) For the common pattern of Bounded Counters, we provide encapsulated data type that is proven correct and is efficient; (iv) in the general case, static analysis can identify when synchronisation is not necessary for correctness.Our Antidote cloud database system supports CRDTs, Transactional Causal Consistency and the Bounded Counter data type. Support tools help design applications by static analysis and proof of CAP-sensitive invariants. This system supports industrial-grade applications and has been tested experimentally with hundreds of servers across several geo-distributed data centres.