Miracle-dz/UniFAR-FTUs huggingface dataset:
Dissipativity for a Class of Stochastic Nonlinear Systems With State-Dependent Switching

Dissipativity of stochastic nonlinear systems with state-dependent switching is investigated in this brief. Switching instants are introduced reasonably, based on the evolution of the state trajectory, which are proved to be stopping times. They are the key to apply Itô's formula and Dynkin's formula in stochastic systems. Based on these stopping times, some sufficient conditions on dissipativity of switched stochastic systems are provided. Furthermore, the criteria on global asymptotic stability and input-to-state stability in probability are presented by using a common Lyapunov function technique and multiple Lyapunov functions techniques, respectively. Finally, a numerical example is given to illustrate the validity of our results.
Possible molecular basis for antiviral activity of certain 5-substituted deoxyuridines

The antiviral activity of five structurally related pyrimidine nucleosides, E-5-propenyl-2'-deoxyuridine, 5-allyl-2'-deoxyuridine, E-5-(1-butenyl)-2'-deoxyuridine, 5-(2-butenyl)-2'-deoxyuridine, and 5-butyl-2'-deoxyuridine, in cell culture against herpes simplex virus type 1 was examined. Analogs in which the C-C double bond of the 5-substituent was in conjugation with the pyrimidine ring were more potent antiviral drugs than were the corresponding nonconjugated and alkyl-substituted analogs. Differences in antiviral activity similar to those observed in cell culture occurred in virus-infected mice. The molecular basis for the greater antiviral activity of the conjugated isomers was investigated. It was observed that the conjugated isomer E-5-propenyl-2'-deoxyuridine had a greater affinity for virus thymidine kinase and, as the 5'-triphosphate, for virus DNA polymerase than did the nonconjugated isomer 5-allyl-2'-deoxyuridine. The results are discussed in relation to other data in the literature.
Electron microscopic study on the development of the carotid body and glomus cell groups distributed in the wall of the common carotid artery and its branches in the chicken

Development of the carotid body and the glomus cell groups in the wall of the common carotid artery and its branches was studied in chickens at various developmental stages by electron microscopy. At 8 days of incubation, the carotid body anlage consisted of mesenchyme‐like cells, whereas the clusters of epithelial cells, which occasionally contained a few dense‐cored vesicles and were accompanied by unmyelinated nerve fibers, were located in the region surrounding the carotid body anlage and in the wall of the common carotid artery. Subsequently, the granule‐containing cells together with nerve fibers were detected in the periphery of the carotid body anlage. At 12 days of incubation, a large number of granule‐containing cells (glomus cells) were dispersed throughout the carotid body parenchyma and were also widely distributed along the common carotid artery and its branches. The cells frequently extended long cytoplasmic processes that made contact with other glomus cells and nerve fibers. Synaptic junctions which showed desmosome‐like thickening of pre‐ and postsynaptic membranes and accumulations of small clear vesicles (around 50 nm in diameter) were first detected along the contact between the long axons and glomus cells at 12 days of incubation. In the wall of the common carotid artery, interdigitations between the cytoplasmic processes of glomus cells and smooth muscle cells began to form. Sustentacular cells investing partly the glomus cells were also discerned both in the carotid body and around the arteries at this stage. At 14 days of incubation, the glomus cells expressed most of the characteristics of the mature cells, and the synaptic junctions displaying afferent morphology appeared; the secretory granules of glomus cells were accumulated near and attached to the desmosome‐like thickening of apposed membranes. © 1994 Wiley‐Liss, Inc.
Simultaneous Determination of Multiple Active Components from Bushen Pills and Application in a Pharmacokinetic Study in Rats

Bushen Pills (BSPs), as a traditional Chinese medicine (TCM), is widely used in clinic to enrich Yang, nourish Yin, stem essence, and strengthen kidneys. Two chromatographic methods, liquid chromatography-mass spectrometry (LC-MS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS), were applied to analyze the multiple active components of BSPs in dosage form for quality evaluation and in rat plasma for pharmacokinetics study, respectively. Three active constituents of BSPs, including paeoniflorin (PF), berberine hydrochloride (BBR), and schizandrin (SCH), were simultaneously determined by the established LC-MS method with electrospray ionization (ESI) in positive selected ion monitoring (SIM) mode at m/z 503.1, 336.0, and 455.2. The contents of PF, BBR, and SCH were (6.112 ± 0.166) mg/g, (335.1 ± 14.95) μg/g, and (5.867 ± 0.136) μg/g in BSPs. On this basis, PF and BBR were selected as targeted analytes for the pharmacokinetic study of BSPs in rats. Memantine hydrochloride was used as an internal standard (IS), and the plasma samples were processed by liquid-liquid extraction with ethyl acetate. All the analytes were separated on a C18 reversed phase column, eluted with a mobile phase consisting of acetonitrile-formic acid (0.01%) (25 : 75, v/v), and detected by ESI in the selected ion mode with multiple reaction monitoring (MRM). The target fragment ions were m/z 525.3 ⟶ 449.5 for PF, 336.2 ⟶ 320.2 for BBR, and 180.1 ⟶ 163.1 for IS. The linear ranges of PF and BBR were 5–500 ng/mL and 0.1–20 ng/mL with good linearity (r2 > 0.99). No obvious matrix effect was observed, and acceptable accuracy, precision, recovery, and stability were obtained. The proposed method has been successfully applied to the pharmacokinetic study of BSPs in rats after a single dose.
Liver Care and Surveillance: The Global Impact of the COVID‐19 Pandemic

As social distancing and strict stay‐at‐home orders have been instituted to slow the spread of coronavirus disease 2019 (COVID‐19), unintentional outcomes among those with chronic diseases including screening for the lethal hepatocellular carcinoma (HCC) may be occurring. We aimed to describe the changes in liver care before and after COVID‐19 restricted access to health care. We obtained data on the number of liver clinic visits, abdominal ultrasound, computed tomography, and magnetic resonance imaging using electronic query or clinic registry at three medical centers in the United States, Japan, and Singapore for the following periods: February 1 to March 14, 2018, 2019, and 2020; and March 15 to May 1, 2018, 2019, and 2020. We performed trend analysis using logistic regression. In total, 14,403 visits were made to the liver clinics at the three centers: 5,900 in 2018, 5,270 in 2019, and 3,233 in 2020. Overall, there were no significant changes in the distribution of males and females between February 1 and May 1 from 2018 to 2020, but there was a lower proportion of seniors ages 65 years and older (P < 0.001). There were significant decreasing trends in the total number of liver clinic visits overall (p‐trend = 0.038) and in the subanalysis for chronic hepatitis B, C, and other liver diseases. HCC/cirrhosis visits also dropped from 883 to 538 (39.07% decrease) overall and 665 to 355 (46.62% decrease) for the US site. In addition, there was a significant decreasing trend in the number of abdominal ultrasounds (P‐trend = 0.004) and computed tomography/magnetic resonance imaging (P‐trend = 0.007) performed overall. Conclusion: Liver clinic visits, hepatoma surveillance, and diagnostic abdominal imaging fell dramatically as social distancing measures were instituted. Care providers must find ways to recall patients for important care monitoring, including HCC surveillance.
Adenovirus type 5 early region 1b gene product is required for efficient shutoff of host protein synthesis

To determine the role adenovirus 5 early region 1b-encoded 21- and 55-kilodalton proteins play in adenovirus productive infection, mutants have been isolated which were engineered to contain small deletions or insertions at 5.8, 7.9, or 9.6 map units. By using an overlap recombination procedure involving H5dl314 (delta 3.7 to 4.6 map units) DNA cleaved at 2.6 map units with ClaI and the adenovirus 5 XhoI-C (0 to 15.5 map units) fragment containing the desired mutation, viral mutants were isolated by their ability to produce plaques on KB cell line 18, which constitutively expresses only viral early region 1b functions (Babiss et al., J. Virol. 46:454-465, 1983). DNA sequence analysis of the viral mutants isolated (H5dl118, H5dl110, H5in127, and H5dl163) indicates that all of the viruses contain mutations which affect the 55-kilodalton protein, whereas dl118 should also produce a truncated form of the 21-kilodalton protein. When analyzed for their replication characteristics in HeLa cells, all of the mutant viruses exhibited extended eclipse periods and effected yields that were reduced to 10% or less of that produced by H5sub309 (parent virus of the mutants which is phenotypically identical to wild-type adenovirus 5). When compared with characteristics of sub309, the early and late transcription and DNA replication of the mutants were similar, but synthesis of late polypeptides and late cytoplasmic mRNAs was greatly reduced. Quantitation of mutant virus-specific late mRNAs associated with polysomes revealed a threefold reduction when compared with that of sub309. Analysis of infected cell extracts further revealed that these mutants were incapable of efficiently shutting off host cell protein synthesis, suggesting that the 55-kilodalton protein plays a role in this process. These data suggest that early region 1b products may function by interacting with additional viral or host cell macromolecules to modulate host cell shutoff or that some late viral mRNA or polypeptide may potentiate this reaction.
Panel: A call for action in tackling environmental sustainability through green information technologies and systems

In a previous paper, we have found empirical evidence supporting a positive relationship between network centrality and success. However, we have also found that more successful projects have a lower technical quality. A first, straightforward argument explaining previous findings is that more central contributors are also highly skilled developers who are well known for their ability to manage the complexity of code with a lower attention to the software structure. The consolidated metrics of software quality used by the authors in their previous research represent measures of code structure. This paper provides empirical evidence supporting the idea that the negative impact of success on quality is caused by the careless behaviour of skilled developers, who are also hubs within the social network. Research hypotheses are tested on a sample of 56 OS applications from the SourceForge.net repository, with a total of 378 developers. The sample includes some of the most successful and large OS projects, as well as a cross-section of less famous active projects evenly distributed among SourceForge.net’s project categories.
Cortical Networks for Ethologically Relevant Behaviors in Primates

Parietal–frontal networks in primate brains are central to mediating actions. Physiological and anatomical investigations have shown that the parietal–frontal network is consistently organized across several branches of primate evolution that include prosimian galagos, New World owl and squirrel monkeys, and Old World macaque monkeys. Electrical stimulation with 0.5‐sec trains of pulses delivered via microelectrodes evoked ethologically relevant actions from both posterior parietal cortex (PPC) and frontal motor cortex (FMC). Reaching, grasping, defensive, and other complex movement patterns were evoked from domains that had a characteristic organization in both FMC and PPC. Although a PPC domain (e.g. reaching) may be connected with other PPC domains (e.g. grasping and defensive), its connections with FMC are preferential for a matching domain (reaching). Similarly, electrical stimulation of a PPC domain and concurrent optical imaging of FMC, showed activation patterns consistent with the preferential connectivity of PPC and FMC domains. The evidence for similar arrangements of interconnected functional domains in PPC and FMC of members of three major branches of the primate radiation suggests that the parietal–frontal networks emerged early in the evolution of primates. The small size of PPC in the close relatives of primates including lagomorphs, rodents, and tree shrews, suggests a limited involvement of PPC in motor behavior before archaic primates emerged. However, functional domains may have evolved in motor cortex before the emergence of archaic primates. Am. J. Primatol. 75:407‐414, 2013. © 2012 Wiley Periodicals, Inc.
Schizophrenics Fully Remitted on Neuroleptics for 3–5 years—To Stop or Continue Drugs?

Summary A double-blind comparison between benzodiazepines and neuroleptics was carried out for 1 ½ years on 30 schizophrenics who had hitherto continuously received neuroleptics and remained apparently in full remission for at least 3–5 years. The benzodiazepine-group had a significantly higher relapse rate than the neuroleptic-group, meaning that we cannot stop neuroleptics for these patients yet. Three possible reasons for this are (1) demand of the natural course of the illness, (2) the fact that the patients agreed to stay in therapy for so long may signify a need for therapy, (3) some of the relapses on stopping neuroleptics may be ‘withdrawal psychosis' after prolonged neuroleptic therapy. If withdrawal of neuroleptics is really needed, however, it may be considered for a subgroup of female patients whose illness started after the age of 40.
The Mystery of the Vanishing Benefits: An Introduction to Impact Evaluation

This article provides an introduction to the concepts and methods of impact evaluation. The author provides an intuitive explanation in the context of a concrete application. The article takes the form of a short story about a fictional character's on-the-job training in evaluation. Ms. Speedy analyst is an economist in the Ministry of Finance in the fictional country of Labas. In the process of figuring out how to evaluate a human resource program targeted to the poor, Ms. Analyst learns the strengths and weaknesses of the main methods of ex post impact evaluation.
Bivalirudin as a replacement for unfractionated heparin in unstable angina/non-ST-elevation myocardial infarction: observations from the TIMI 8 trial. The Thrombolysis in Myocardial Infarction.

BACKGROUND The Thrombolysis in Myocardial Infarction (TIMI) 8 trial was undertaken to compare the efficacy and safety of bivalirudin versus unfractionated heparin in a double-blind phase III trial of patients with unstable angina/non-ST-elevation myocardial infarction (MI). METHODS All patients received aspirin and were randomized either to unfractionated heparin (bolus of 70 U/kg followed by an infusion of 15 U/kg/h) or bivalirudin (bolus of 0.1 mg/kg followed by an infusion of 0.25 mg/kg/h) for a minimum of 72 hours. The primary efficacy end point was a composite of all cause mortality or nonfatal recurrent MI. RESULTS A total of 133 of the planned 5320 patients were enrolled, at which point the study was terminated by the sponsor because of a decision at the time to suspend further development of bivalirudin. Through 14 days, the incidence of death or nonfatal MI was 9.2% in the 65 patients in the unfractionated heparin group and was 2.9% in the 68 patients in the bivalirudin group, odds ratio (95% CI) 0.30 (0.06-1.53). Major hemorrhage occurred in 3 patients in the unfractionated heparin group (4.6%) but in none of the patients in the bivalirudin group (P =.11). CONCLUSIONS The trend toward a lower rate of death or nonfatal MI in the bivalirudin group is consistent with a therapeutic effect of the drug and is consistent with other trials of bivalirudin in patients with acute coronary syndromes. The potential for clinically meaningful antithrombotic activity without an increased risk of bleeding and availablility of an alternative anticoagulation strategy in patients who cannot tolerate unfractionated heparin are particularly attractive and underscore the need for further evaluation of bivalirudin.
Evaluation the biological effect of two types of denture base materials reinforced with silanated glass fiber

Background: Many attempts to improve the mechanical properties of acrylic denture base materials by adding filler such as silanated glass fiber (SGF). This new product (acrylic resin +SGF) need to evaluate its biocompatibility because of its application in direct contact with the living tissue. The aim of this study was to evaluate the Biological Effect of two types of denture base materials (heat-cured, light-cured) reinforced with randomly oriented short (SGF) at four different times. Materials and Methods: Specimens of heat and light cured denture base materials reinforced with (2mm length, 2wt %) (SGF) was implanted in the subcutaneous tissue at the back of the Newsland rabbits. Biopsies for histopathological observation were taken after (3days, 7days, 14days, and 30days). Results: Histopathological observation showed mild to moderate inflammation in the subcutaneous tissue of the rabbits, and tissue acceptance improved over times. Conclusion: It was noted that silanated glass fiber is a biocompatible material when added to heat-cured and lightcured resins. Both resins demonstrated good level of biocompatibility within the connective tissue of the rabbit. Key word: Biological Effect, Denture Base Materials, silanated glass fiber. (J Bagh Coll Dentistry 2011;23(2):26-30).
Estimation of salivary neopterin in chronic periodontitis.

BACKGROUND Periodontal diseases are the most common bacterial infection predominantly associated with Gram-negative microorganisms that exist in the subgingival biofilm. Analysis of saliva provides a noninvasive means of evaluating the role of the host response in periodontal disease. Though salivary enzymes can be used as the biomarkers, neopterin has been recently used as one of the important diagnostic tools in the field of periodontics. Hence, we aimed to identify the neopterin levels in unsimulated saliva from the chronic periodontitis patients and compare them with the periodontally healthy subjects. MATERIALS AND METHODS Twenty subjects participated in the study and were categorized as the experimental group (chronic periodontitis patients) and control groups (healthy subjects). Unstimulated saliva samples were collected from both the groups for neopterin estimation. Neopterin in saliva was estimated using Shimadzu High Performance Liquid Chromatography with LC-20AD pump system, equipped with RF-10 AXL fluorescence detector. STATISTICAL ANALYSIS USED Data were expressed as mean±SD and analyzed using GraphPad Prism version 6.0 (California, USA). Statistical analysis was done by Student's t-test. RESULTS The neopterin level in unstimulated saliva was found to be higher in the experimental group than the control group with P≤0.05. CONCLUSIONS The chronic periodontitis patients showed higher neopterin level in unstimulated saliva as compared to control. Hence, neopterin can be used as a potential biomarker for identification of the periodontal disease in its initial stage can help in preventing the disease progression.
Biotechnological Process for Production of β-Dipeptides from Cyanophycin on a Technical Scale and Its Optimization

ABSTRACT A triphasic process was developed for the production of β dipeptides from cyanophycin (CGP) on a large scale. Phase I comprises an optimized acid extraction method for technical isolation of CGP from biomass. It yielded highly purified CGP consisting of aspartate, arginine, and a little lysine. Phase II comprises the fermentative production of an extracellular CGPase (CphEal) from Pseudomonas alcaligenes strain DIP1 on a 500-liter scale in mineral salts medium, with citrate as the sole carbon source and CGP as an inductor. During optimization, it was shown that 2 g liter−1 citrate, pH 6.5, and 37°C are ideal parameters for CphEal production. Maximum enzyme yields were obtained after induction in the presence of 50 mg liter−1 CGP or CGP dipeptides for 5 or 3 h, respectively. Aspartate at a concentration of 4 g liter−1 induced CphEal production with only about 30% efficiency in comparison to that with CGP. CphEal was purified utilizing its affinity for the substrate and its specific binding to CGP. CphEal turned out to be a serine protease with maximum activity at 50°C and at pH 7 to 8.5. Phase III comprises degradation of CGP to β-aspartate-arginine and β-aspartate-lysine dipeptides with a purity of over 99% (by thin-layer chromatography and high-performance liquid chromatography), employing a crude CphEal preparation. Optimum degradation parameters were 100 g liter−1 CGP, 10 g liter−1 crude CphEal powder, and 4 h of incubation at 50°C. The overall efficiency of phase III was 91%, while 78% (wt/wt) of the used CphEal powder with sustained activity toward CGP was recovered. The optimized process was performed with industrial materials and equipment and is applicable to any desired scale.
Accelerated Myelinogenesis by Dietary Lipids in Rat Brain

Abstract: Our previous work showed an early development of behavioral reflexes in rats whose mothers had been fed, during pregnancy and lactation, a lipid fraction extracted from yeast grown on n‐alkanes (which contain 50% odd‐chain fatty acids) in comparison with controls fed a margarine diet. To clarify whether the observed changes might be linked to an early myelination, we have investigated mRNAs involved in myelin synthesis in the brains of offspring at 5 days of age by northern blot and in situ hybridization. Northern blot analysis showed that proteolipid protein (PLP) and myelin oligodendrocyte glycoprotein (MOG) mRNAs were higher in animals on the lipid diet compared with controls. In situ hybridization with probes specific for PLP, myelin basic protein, and MOG mRNA showed significantly higher numbers of positive cells in test animals compared with controls in all brain regions. This study shows an acceleration of myelinogenesis induced by dietary lipids. These data can give a new insight in the therapeutical approaches involved to promote repair in demyelinating diseases.
Lymphomatous proptosis as a novel feature of mantle cell lymphoma

We describe eight cases of acute proptosis due to mantle cell lymphoma (MCL), among 26 consecutive MCL cases. The median time of onset was 29 months (range 0–102) from diagnosis. Two cases presented initially with orbital masses while five as sudden disease progression after multiple courses of chemotherapy. In each case, there was dramatic loss of vision and severe proptosis, which uniformly responded to radiotherapy and/or further chemotherapy. Unilateral blindness only occurred in two cases, with recurrent orbital relapse and repeated retinal irradiation and retro-orbital optic nerve involvement, respectively. The high incidence, as well as bilateral and recurrent nature, of orbital involvement suggested a homing mechanism of MCL to this site. Despite the absence of central nervous system involvement, most cases died of refractory disease. Apart from lymphomatous polyposis of the gut, MCL cells also show predilection to ocular presentation, and must be considered as a differential diagnosis to maltoma in the two anatomical sites.
ERASP: A new reflectarray antenna for space applications

THALES Airborne Systems (TAS) has developed a new reflectarray design that has proven to be a potentially interesting device suited for space applications like Synthetic Aperture Radars and Telemetry subsystems. This document presents this new reflectarray technology (called ERASP). After a short presentation of the technology, we present radiofrequency measurements results of an engineering model. The measurements have been realized in the CNES antenna test facility.