Miracle-dz/UniFAR-FTUs huggingface dataset:
Pathological features and prognosis of different molecular subtypes of breast cancer.

To examine the pathological features and prognosis of different molecular subtypes of breast cancer, the clinical data of 892 breast cancer patients were retrospectively analyzed and divided into four subtypes according to hormone receptor expression in breast cancer tissue: Her-2 overexpression, luminal A, luminal B and basal-like subtypes. The pathological data and prognosis of these subtypes were compared. Of the 892 breast cancer patients, there were 46 cases (5.2%) with Her-2 overexpression-type, 698 cases (78.3%) with luminal A-type, 38 cases (4.3%) with luminal B-type and 110 patients (12.2%) with basal-like-type. Immunohistochemistry was used to identify the progesterone and estrogen receptors in the tumor tissues. The χ2 test was used to verify the measurement data. The Cox proportional hazard regression model was used for the univariate and multivariate analyses. Results showed there was no statistical difference for lymphatic metastasis among the various molecular subtypes of breast cancer (P>0.05). The distant metastatic rate of patients with Her-2-type breast cancer was significantly higher compared to patients with the other three subtypes (P<0.05). The difference in local recurrence among molecular subtypes was not significantly significant (P>0.05). Lymph node metastasis, age and different molecular subtypes were found to have an impact on patient overall survival (OS) and disease-free survival (DFS). Her-2 overexpression-type breast cancer patients had the lowest 9-year DFS and 7-year OS compared to the other subtypes (P<0.05). Thus, Her-2-type was associated with the worst prognosis. In conlusion, the molecular typing of breast cancer has important clinical value in prognosis estimation and is expected to affect breast cancer treatment approaches.
Aging, Recall and Recognition: A Study on the Sensitivity of the University of Southern California Repeatable Episodic Memory Test (USC-REMT)

This study examines the sensitivity of the University of Southern California Repeatable Episodic Memory Test (USC-REMT) to the effects of aging in a sample of 112 men and women from 18 to 93 years old. Two new recognition measures, yes-no and forced-choice, were developed to supplement the original USC-REMT which measured only free-recall. Free-recall, yes-no recognition and forced-choice recognition were sensitive to age effects, with free-recall being the most sensitive. The seven recall and recognition lists can be used interchangeably. The data indicate that the USC-REMT is worthy of consideration when there is a need for a brief, screening tool of various memory functions, particularly when there is interest in memory changes over time and repeated assessments.
Does Property Rights Protection Affect Corporate Risk Management Strategy? Intra- and Cross-Country Evidence

Recent studies in the law and finance literature have shown that property rights protection is central to corporate financing and investment decisions and economic growth at large. We extend this literature by examining the effect of property rights security on corporate risk management decisions — an important element of a firm's business strategy. Using a unique dataset covering over 55,000 Chinese firms and employing both institution- and firm-level measures of property rights security, we find that secure property rights lead to higher corporate demand for property insurance, suggesting that property rights security is an important determinant of corporate risk management decisions. The effect of property rights protection on insurance consumption is also validated by a cross-country analysis that uses data from 93 countries over the period 1995–2008. Our study sheds light on the importance of property rights protection to corporate risk management decisions.
Understanding MCP‐MOD dose finding as a method based on linear regression

MCP‐MOD is a testing and model selection approach for clinical dose finding studies. During testing, contrasts of dose group means are derived from candidate dose response models. A multiple‐comparison procedure is applied that controls the alpha level for the family of null hypotheses associated with the contrasts. Provided at least one contrast is significant, a corresponding set of “good” candidate models is identified. The model generating the most significant contrast is typically selected. There have been numerous publications on the method. It was endorsed by the European Medicines Agency.
Etiology of recurrent acute pancreatitis, with special emphasis on pancreaticobiliary malformation.

PURPOSE This study was aimed to investigate etiology and clinical profiles of recurrent acute pancreatitis (RAP), particularly from the morphology of the pancreaticobiliary duct system. MATERIAL AND METHODS Pancreaticobiliary morphology was examined in 230 of 381 patients with acute pancreatitis (AP) using endoscopic retrograde cholangiopancreatography. We analyzed factors associated with RAP including the pancreaticobiliary duct system. RESULTS RAP was diagnosed in 74 patients (19%). Major etiologies of RAP were alcoholic (38%), idiopathic (26%) and pancreaticobiliary malformation (22%). Patients with alcoholic RAP were significantly younger (47.2±11.6 years) than those with gallstone RAP (67.3±16.8; p<0.05). RAP with pancreaticobiliary malformation (male-to-female ratio: 1:4.3; p<0.01) and gallstone RAP (1:1.7; p<0.05) occurred predominantly in females in comparison with alcoholic RAP (1:0.2). Recurrence rate was 80% for AP with pancreaticobiliary malformation, significantly higher than for the others (p<0.01). Pancreas divisum was suspected as the etiology of mild RAP in 7 patients. Four RAP patients with pancreas divisum underwent endoscopic minor papilla sphincterotomy and improved. Pancreaticobiliary maljunction with biliary dilatation (choledochal cyst) was suspected as the etiology of mild RAP in 3 patients. The 3 RAP patients with choledochal cyst underwent prophylactic flow diversion surgery with complete resection of the dilated common bile duct, and achieved improvement. High confluence of pancreaticobiliary ducts was suspected as the etiology of mild RAP in 6 patients. CONCLUSION Pancreaticobiliary malformation is one of the major causes of RAP. As some of them benefit from endoscopic or surgical treatment, morphology of the pancreaticobiliary duct system should be examined where possible in RAP patients.
Changes in Apparent Resistivity in the Late Preparation Stages of Strong Earthquakes

In China, a large-scale observation network that is comprised of a number of apparent resistivity (for short, AR) stations has been established for the purpose of earthquake (EQ) monitoring and prediction since the 1966 Ms7.2 Xingtai EQ in Hebei Province. Presently, over 70 AR stations are in observation in seismically active belts in densely populated areas and nearby some of large, medium-sized cities. The 2008 Ms8.0 Wenchuan great EQ in Sichuan province occurred in the AR station network that was located in the border area of both Sichuan and Gansu provinces. In the 1970s-1980s, more than 110 AR stations had been in observation, and in those years, several great earthquakes (EQs) occurred nearby AR stations, such as the 1976 Ms7.8 Tangshan EQ in Hebei province, the 1976 Ms7.2 SongpanPingwu EQ in Sichuan province, the 1976 Ms7.4 Longling EQ in Yunnan province, and the 1988 Ms7.6 Lancang-Gengma EQ in Yunnan Province. At an AR station, two horizontally perpendicular observation channels or three channels, more one horizontally skewed channel (a NE or NW channel, as illustrated in Fig.1a), are employed, and for each channel, an AR observation configuration with a symmetry four-electrode array is installed (Fig.1b). For most stations, the current electrode spacing AB 1000 ~ 2000m  .
Ubiquitin-Fused and/or Multiple Early Genes from Cottontail Rabbit Papillomavirus as DNA Vaccines

ABSTRACT Human papillomavirus (HPV) vaccines have the potential to prevent cervical cancer by preventing HPV infection or treating premalignant disease. We previously showed that DNA vaccination with the cottontail rabbit papillomavirus (CRPV) E6 gene induced partial protection against CRPV challenge and that the vaccine's effects were greatly enhanced by priming with granulocyte-macrophage colony-stimulating factor (GM-CSF). In the present study, two additional strategies for augmenting the clinical efficacy of CRPV E6 vaccination were evaluated. The first was to fuse a ubiquitin monomer to the CRPV E6 protein to enhance antigen processing and presentation through the major histocompatibility complex class I pathway. Rabbits vaccinated with the wild-type E6 gene plus GM-CSF or with the ubiquitin-fused E6 gene formed significantly fewer papillomas than the controls. The papillomas also required a longer time to appear and grew more slowly. Finally, a significant proportion of the papillomas subsequently regressed. The ubiquitin-fused E6 vaccine was significantly more effective than the wild-type E6 vaccine plus GM-CSF priming. The second strategy was to vaccinate with multiple CRPV early genes to increase the breadth of the CRPV-specific response. DNA vaccines encoding the wild-type CRPV E1-E2, E6, or E7 protein were tested alone and in all possible combinations. All vaccines and combinations suppressed papilloma formation, slowed papilloma growth, and stimulated subsequent papilloma regression. Finally, the two strategies were merged and a combination DNA vaccine containing ubiquitin-fused versions of the CRPV E1, E2, and E7 genes was tested. This last vaccine prevented papilloma formation at all challenge sites in all rabbits, demonstrating complete protection.
Area- and efficiency-optimized junction termination for a 5.6 kV SiC BJT process with low ON-resistance

Implantation-free mesa-etched 4H-SiC bipolar junction transistors (BJTs) with a near-ideal breakdown voltage of 5.6 kV (about 92% of the theoretical value) are fabricated, measured and analyzed by device simulation. An efficient and optimized termination; area-optimized three-zone junction termination extension (O-JTE) is implemented, reducing the total area (and substrate cost) by about 30% compared to the traditional JTE designs. A maximum current gain of β = 44 at a current density of 472 A/cm<sup>2</sup>, and a specific on-resistance of R<sub>ON</sub> = 18.8 mΩ. cm<sup>2</sup> is obtained for the device. The device shows a negative temperature coefficient of the current gain (β = 14.5 at 200 °C) and a positive temperature coefficient of on-resistance (R<sub>ON</sub> = 57.3 mΩ·cm<sup>2</sup> at 200 °C).
CD4+ T cell count recovery in HIV type 1-infected patients is independent of class of antiretroviral therapy.

BACKGROUND In recent years, treatment options for human immunodeficiency virus type 1 (HIV-1) infection have changed from nonboosted protease inhibitors (PIs) to nonnucleoside reverse-transcriptase inhibitors (NNRTIs) and boosted PI-based antiretroviral drug regimens, but the impact on immunological recovery remains uncertain. METHODS During January 1996 through December 2004 [corrected] all patients in the Swiss HIV Cohort were included if they received the first combination antiretroviral therapy (cART) and had known baseline CD4(+) T cell counts and HIV-1 RNA values (n = 3293). For follow-up, we used the Swiss HIV Cohort Study database update of May 2007 [corrected] The mean (+/-SD) duration of follow-up was 26.8 +/- 20.5 months. The follow-up time was limited to the duration of the first cART. CD4(+) T cell recovery was analyzed in 3 different treatment groups: nonboosted PI, NNRTI, or boosted PI. The end point was the absolute increase of CD4(+) T cell count in the 3 treatment groups after the initiation of cART. RESULTS Two thousand five hundred ninety individuals (78.7%) initiated a nonboosted-PI regimen, 452 (13.7%) initiated an NNRTI regimen, and 251 (7.6%) initiated a boosted-PI regimen. Absolute CD4(+) T cell count increases at 48 months were as follows: in the nonboosted-PI group, from 210 to 520 cells/muL; in the NNRTI group, from 220 to 475 cells/muL; and in the boosted-PI group, from 168 to 511 cells/muL. In a multivariate analysis, the treatment group did not affect the response of CD4(+) T cells; however, increased age, pretreatment with nucleoside reverse-transcriptase inhibitors, serological tests positive for hepatitis C virus, Centers for Disease Control and Prevention stage C infection, lower baseline CD4(+) T cell count, and lower baseline HIV-1 RNA level were risk factors for smaller increases in CD4(+) T cell count. CONCLUSION CD4(+) T cell recovery was similar in patients receiving nonboosted PI-, NNRTI-, and boosted PI-based cART.
The Statistical Information on Recidivism - Revised 1 (SIR-R1) Scale: A Psychometric Examination

This report is also available in French. Ce rapport est egalement disponible en francais. Veuillez vousadresser a la direction de la recherche, Service Correctionnel du Canada, 340 avenue Laurier ouest, Ottawa(Ontario) K1A 0P9. Should additional copies be required they can be obtained from the Research Branch,Correctional Service of Canada, 340 Laurier Ave., West, Ottawa, Ontario, K1A 0P9.
Sharp Bounds on Formation-free Sequences

An (r, s)-formation is the concatenation of s permutations over an r-letter alphabet. Formation-free sequences are a generalization of standard Davenport-Schinzel sequences (where r = 2) and can be used to obtain good bounds on the extremal function of any forbidden subsequence. More recently, formation-free sequences have been applied to bounding the size of sets of permutations with fixed VC-dimension. Improving on earlier work by Klazar, Nivasch, and Cibulka and Kyncl, we prove sharp bounds on the length of (r, s)-formation-free sequences, for every r and s, and on sequences avoiding "doubled" (r, s)-formations. There are two take-away messages from our results. The first is that formation-free sequences are qualitatively different than their Davenport-Schinzel counterparts. They behave similarly when r = 2, or when s ≤ 3, or when s ≥ 4 is even, but are different in all other cases. The second message is that sequences avoiding doubled (r, s)-formations behave just like (r, s)-formation-free sequences, though they are substantially more difficult to analyze.
Hepatocyte Growth Factor Concentration in Maternal and Umbilical Cord Blood Samples and Expression in Fetal Liver

Objective: To determine human placenta secretes hepatocyte growth factor (HGF) and could influence fetal liver development. Methods: Expression of HGF and c-met mRNA in samples of first- and second-trimester fetal liver and placenta was compared using a quantitative ribonuclease protection assay. Serum HGF concentration in 30 samples of paired umbilical and maternal blood from term pregancies was evaluted using an enzyme-linked immunosorbent assay. Results: HGF and c-met mRNA were expressed in similar levels in liver and placent, with expression increasing from 9 to 16 weeks' gestation. Median serum HGF values were 1.4 ng/mL (maternal venous), 1.2 ng/mL (cord venous), and 1.3 ng/mL (cord arterial). The maternal venous HGF levels were significantly higher than fetal venous levels (P = .02). Conclusions: This study does not support the hypothesis that the placenta secretes HGF, because maternal serum levels were higher then fetal and there was no significant difference beween umbilical arterial and venous samples. Fetal liver expresses abundant HGF mRNA during the first ans second trimester and expression increases in line with receptor (c-met) expression, suggesting that hepatic growth and development are independent of placental HGF.
Genetic correlations between dressage, show jumping and studbook‐entry inspection traits in a process of specialization in Dutch Warmblood horses

Sport performance in dressage and show jumping are two important traits in the breeding goals of many studbooks. To determine the optimum selection scheme for jumping and dressage, knowledge is needed on the genetic correlation between both disciplines and between traits measured early in life and performance in competition in each discipline. This study aimed to estimate genetic parameters to support decision-making on specialization of breeding horses for dressage and show jumping in Dutch warmblood horses. Genetic correlations between performance of horses in dressage and show jumping were estimated as well as the genetic correlation between traits recorded during studbook-entry inspections and performance in dressage and show jumping competitions. The information on competition comprised the performance of 82 694 horses in dressage and 62 072 horses in show jumping, recorded in the period 1993-2012. For 26 056 horses, information was available for both disciplines. The information on traits recorded at studbook-entry inspections comprised 62 628 horses, recorded in the period 1992-2013. Genetic parameters were estimated from the whole dataset and from a subset without horses recorded in both disciplines. Additionally, the genetic parameters were estimated in three different time periods defined by horses' birth year. The genetic correlation between dressage and show jumping in the whole dataset was -0.23, and it was -0.03 when it was estimated from horses recorded in only one discipline. The genetic correlation between dressage and show jumping was more negative in the most recent time period in all the cases. The more negative correlation between disciplines in more recent time periods was not reflected in changes in the correlations between competitions traits and the traits recorded in the studbook-first inspection. These results suggest that a breeding programme under specialization might be most effective defining two separate aggregate breeding goals for each of the disciplines.
Behavioral effects and pharmacokinetics of propofol in rats selected for differential ethanol sensitivity.

High- and low-alcohol sensitivity (HAS and LAS) rats have been selected for their differences in ethanol-induced sleep time. The rats also differ in sensitivity to pentobarbital, halothane, isoflurane, and enflurane. To determine if this sensitivity extended to propofol, the anesthetic requirements were measured. In this study, the sleep time and the tissue levels of propofol at awakening, as well as the pharmacokinetics, were evaluated. Propofol was administered intravenously. For one group of rats, sleep times were measured; blood and brain samples were taken at awakening. Blood samples were collected in another group of rats at frequent intervals from 0 to 90 min after injection. Propofol concentration of the samples was determined by gas chromatography. The pharmacokinetic analysis was performed using a nonlinear least-squares regression program. Sleep time was not different; however, blood and brain propofol levels at awakening showed a small, but significant difference between HAS and LAS rats. Propofol blood concentration-time curve data were fitted to a three-compartment model. Pharmacokinetic parameters were also not different between the rat lines. However, sleep time was 50% longer in female rats than male rats in both strains (p < 0.0001). The rates of propofol clearance were slower in female rats, because of different rates of disappearance from the second compartment. The observations suggest that the genetic selection for ethanol sensitivity selection for propofol sensitivity was not nearly as intense and presumably involves some different genes. These two central nervous system depressants would seem to differ significantly in their mechanism of action. (ABSTRACT TRUNCATED AT 250 WORDS)
Cytosolic Accumulation of HSP60 during Apoptosis with or without Apparent Mitochondrial Release

Most heat shock proteins (HSPs) have pro-survival functions. However, the role of HSP60, a mitochondrial matrix protein, is somewhat controversial with both pro-survival and pro-apoptotic functions reported. Here we show that in numerous apoptotic systems HSP60 protein accumulates in the cytosol. In BMD188-induced cell death, HSP60 accumulates in the cytosol with significant mitochondrial release. In contrast, in apoptosis induced by multiple other inducers, the cytosolic HSP60 accumulates without an apparent mitochondrial release. The short interfering RNA-mediated knockdown experiments revealed that in BMD188-induced apoptosis, HSP60 has a pro-death function and that the pro-death role of HSP60 seems to involve caspase-3 maturation and activation in the cytosol. In contrast, HSP60 appears to play a pro-survival role in other apoptotic systems where there is no apparent mitochondrial release as its knockdown promotes cell death. In these latter apoptotic systems HSP60 does not associate with active caspase-3. In both cases, HSP60 does not appreciably interact with Bax. Taken together, our results suggest the following: 1) cytosolic accumulation of HSP60 represents a common phenomenon during apoptosis induction; 2) cytosolic HSP60 accumulation during apoptosis occurs either with or without apparent mitochondrial release; and 3) the cytosolically accumulated HSP60 possesses either pro-survival or pro-death functions, which involves differential interactions with caspase-3.
Involvement of the human subthalamic nucleus in movement preparation

Background: Although it has long been recognized that the basal ganglia play a major role in motor control, their precise functions remain unclear. As patients with Parkinson’s disease (PD) have difficulties initiating movement, the basal ganglia may be involved in movement preparation. The subthalamic nucleus (STN) is particularly suited to play a role in movement preparation because it receives direct input from the supplementary motor area through the corticosubthalamic pathway. Methods: Taking advantage of the electrodes surgically implanted in the STN for deep brain stimulation (DBS) treatment in 13 PD patients, we recorded from the DBS electrodes and the scalp simultaneously while the patients were performing self-paced wrist extension movements. Results: Scalp recordings showed a slow, negative movement-related potential (MRP) in all patients studied (onset 1,690 ± 336 milliseconds before electromyography onset). STN recordings showed premovement MRP in 11 of 13 patients. The STN activity occurred with both ipsilateral and contralateral hand movement. The onset time for STN MRP (contralateral 2,095 ± 1,005 milliseconds, ipsilateral 2,020 ± 920 milliseconds) was not significantly different from that for cortical MRP. Conclusion: The STN or nearby structures are active before self-paced movement in humans.
Testing the Reliability and Validity of Computer‐mediated Social Support Measures Among Older Adults: A Pilot Study

With the increasing number of older adult online users, the Internet and e-mail are becoming a new source of social support for older adults. To assess this computer-mediated social support, two traditional social support measures were modified: (1) the Lubben Social Network Scale and (2) the Medical Outcomes Study Social Support Survey. The purpose of this pilot study was to test the reliability and validity of these modified measures. This study was a single group descriptive study with two data collection points. Data were collected using Web surveys. A total of 38 older adult participants completed the first survey; 35, the second survey. The findings of this preliminary study provided evidence for the reliability, content validity, and, to a limited extent, construct validity, of the modified measures. Additional studies with a larger representative sample are needed to further examine the psychometric aspects of these measures.