Miracle-dz/UniFAR-FTUs huggingface dataset:
A randomized, controlled exploratory study of clonidine in diarrhea-predominant irritable bowel syndrome.

BACKGROUND & AIMS The aim of this study was to evaluate the efficacy and tolerability of the alpha-2 adrenoreceptor agonist, clonidine, in patients with diarrhea-predominant irritable bowel syndrome (D-IBS) in a double-blind, randomized, parallel-group, placebo-controlled trial. METHODS A 2-week run-in evaluated baseline symptoms. Patients received 0.05, 0.1, or 0.2 mg clonidine or placebo twice a day for 4 weeks. We evaluated satisfactory relief of IBS by weekly question and stool parameters with a daily diary. Satisfactory relief and overall bowel function were primary end points. Secondary end points were stool frequency, consistency, and ease of passage; gut transit; and fasting and postprandial gastric volumes. Analysis followed intention-to-treat principles. RESULTS Forty-four D-IBS patients participated; there were 4 treatment-related dropouts: 2/2 in the 0.2-mg and 2/12 in the 0.05-mg clonidine groups. Proportion with satisfactory relief of IBS was 0.46, 0.42, and 0.67 with placebo, 0.05 mg, and 0.1 mg clonidine, respectively. Relief was sustained through 4 weeks of treatment, and bowel dysfunction (firmer stools and easier stool passage [P < 0.05]) was reduced with clonidine, 0.1 mg twice a day. Clonidine did not significantly alter gastrointestinal transit or gastric volumes. Drowsiness, dizziness, and dry mouth were the most common adverse events with the 0.1-mg dose; severity of adverse effects subsided after the first week of treatment. A trial to replicate 20% or more responders with clonidine will require 95 patients per treatment arm. CONCLUSIONS Clonidine, 0.1 mg twice a day for 4 weeks, relieves bowel dysfunction and appears promising for relief of D-IBS; these effects are unassociated with significant alterations in transit.
Identification of cis-Elements That Regulate Gene Expression during Initiation of Axillary Bud Outgrowth in Arabidopsis[w]

Growth regulation associated with dormancy is an essential element in plant life cycles. To reveal regulatory mechanisms of bud outgrowth, we analyzed transcriptomes of axillary shoots before and after main stem decapitation in Arabidopsis (Arabidopsis thaliana). We searched for any enriched motifs among the upstream regions of up-regulated and down-regulated genes after decapitation. The promoters of down-regulated genes were enriched for TTATCC motifs that resemble the sugar-repressive element, whereas the promoters of up-regulated genes were enriched for GGCCCAWW and AAACCCTA, designated Up1 and Up2, respectively. Transgenic plants harboring a reporter gene driven by a tandem repeat of the elements were produced to analyze their function in vivo. Sugar-repressive element-mediated gene expression was down-regulated by the application of sugars but was unaffected after decapitation. In contrast, expression driven by the repeat containing both Up1 and Up2 was up-regulated after decapitation, although the Up1 or Up2 repeat alone failed to induce reporter gene expression in axillary shoots. In addition, disruption of both Up1 and Up2 elements in a ribosomal protein gene abolished the decapitation-induced expression. Ontological analysis demonstrated that up-regulated genes with Up elements were disproportionately predicted to function in protein synthesis and cell cycle. Up1 is similar to an element known to be a potential target for TCP (TEOSINTE BRANCHED1, CYCLOIDEA, PCFs family) transcription factor(s), which regulate expression of cell cycle-related and ribosomal protein genes. Our data indicate that Up1-mediated transcription of protein synthesis and cell cycle genes is an important regulatory step during the initiation of axillary shoot outgrowth induced by decapitation.
Influence of the application of three different elicitors on soybean plants on the concentrations of several isoflavones in soybean seeds.

Soybean [Glycine max (L.) Merr. ] is a rich source of isoflavones that are often affected by biotic and abiotic factors. The objectives of this study were to evaluate the effect of various concentrations of three natural elicitors applied at different soybean growth stages on isoflavone content and to compare the efficiency of several solvent systems in isoflavone extraction and quantification. The isoflavones extracted from R96-3444 soybean using eight solvent systems were separated, identified, and quantified by a high-performance liquid chromatography (HPLC) procedure. The soybean plants were sprayed with salicylic acid, methyl salicylate, or ethyl acetate at 0, 10(-6), 10(-3), and 10(-1) M at R1 (blooming) or R4 (full pods) growth stage. Results showed that 10(-3) M ethyl acetate sprayed at the R1 stage significantly increased total isoflavone content and the levels of some individual isoflavones in soybean seeds. With all the elicitors that were tested, concentration was a more important factor than application time with respect to isoflavone content with lower concentrations being more effective on most isoflavones. A 53% acetonitrile solvent system was the best solvent system for extracting total isoflavone, malonyl glucosides, genistein, glycitin, genistin, acetyl-daidzin, and acetyl-genistin. The results of this study will be useful for increasing the isoflavone content in desirable soybean varieties and improving isoflavone concentration during extraction.
Greenhouse Gas Emissions and Health Outcomes in Nigeria: Empirical Insight from ARDL Technique

This study examines the long-run effect of emissions of greenhouse gas (GHG) on health outcomes in Nigeria using time series data from 1985 to 2016 engaging the auto-regressive distribution lag (ARDL) econometric approach to cointegration and it was observed that human activities increase GHG to the atmosphere, this is through combustion of fossil fuels and CO2 , these are two major sources of GHG emissions (GHGE). When the quantity of carbon dioxide increases in the air, more heat is stored in the atmosphere; and this comes upon human beings thereby causing a great harmful effect to human health. The result from ARDL econometric approach to cointegration shows that 1% increase in GHGE reduces life expectancy by 0.0422% which is used as a proxy for health outcome, if this happens, invariably, mortality rate will be 146.6%. Therefore, the major strategy among others recommended in this study for controlling gaseous emissions and increase life expectancy is public health expenditure as the results also shows that 1% increase in government health care expenditure increases life expectancy approximately by 18.10%.
How Does Access to Formal Finance Affect Household Welfare Dynamics? Micro Evidence from Nigeria

The relationship between access to formal finance and poverty reduction lies at the heart of the development literature and policy discourse, particularly in developing countries, where access to financial services is often argued to have poverty-alleviating potential. Most of the stylised theoretical literature and empirical evidence, however, focus their efforts on the poverty-alleviating potential of access to finance at a given point in time, which ignores the dynamic and multidimensional nature of poverty. Using a nationally representative panel data set of households, this paper explores the effect of access to formal finance on household welfare dynamics in Nigeria between 2010–11 and 2012–13. Applying a bivariate probit model, which addresses the endogenous selection associated with households’ initial welfare status, our estimates indicate that controlling for the exogeneity of initial household status is relevant when exploring the implications of access to finance for welfare dynamics in Nigeria, as the exogenous treatment of the initial conditioning may distort the correlation coefficients of our estimates. Our results suggest that access to formal finance has poverty-reducing effects, as we found that initially poor households with access to finance were less likely to remain poor in the subsequent period. Also, initially non-poor households with access to finance were seen to face a lower probability of descending into poverty over the period, thus suggesting that access to finance plays a significant role in reducing transient poverty.
Analysis of Somatic Hypermutations of Immunoglobulin Gene Rearrangements in Childhood Acute Lymphoblastic Leukemia

The current study investigated the presence, frequency, and status of somatic hypermutations as well as their role in children with B lineage ALL. The obtained sequences were analyzed using IMGT/V-QUEST. Totally, 150 IGH sequences were evaluated; 139 from the 111 patients at the time of diagnosis and 11 from 8/111 patients at the time of relapse. The findings of the current report revealed the presence of somatically mutated V genes in childhood B lineage ALL. A higher frequency of somatic hypermutations was noted in unproductive rearrangements and was generally attributed to nucleotide mutation type, region, and IGHV gene subgroup biases.
Does financial innovation improve performance? An analysis of process innovation used in Pakistan

The study aims at quantifying the impact of innovative methods of payment used in Pakistan on the efficiency ratio (ER). Secondary data issued by the State Bank of Pakistan for the period 2007-2016 is used. Through the unit root test, the issue of stationary imperfection connected with unsynchronized arrangement information is settled before using multiple regression models. The result of the study indicated a significant positive relation of transactions on the Web/Internet on ER. But the results for Automated Teller Machines (ATM), Point of Sale (POS), and Mobile Banking (MOB), were found to be statistically non-significant. Furthermore, the Granger impact appraisal revealed that no innovative products had a critical effect on ER, but they did have a significant effect on the value of transactions. Thus, it is suggested that innovative methods should be redesigned in such a way that customization would enable a customer to access all banking services and reduce transaction costs.JEL Codes: O, O3, O31, O310
Prevalence, 20-month incidence and outcome of unipolar depressive disorders in a community sample of adolescents

Background. This article presents prospective longitudinal findings on prevalence, incidence, patterns of change and stability of depressive disorders in a community sample of 1228 adolescents. Methods. Data were collected at baseline and follow-up (20 months later) in a representative population sample of 1228 adolescents, aged 14–17 at baseline. Diagnostic assessment was based on the Munich Composite International Diagnostic Interview (M-CIDI). Results. The overall cumulative lifetime incidence of any depressive condition was 20·0% (major depressive disorder (MDD), 12·2%; dysthymia, 3·5%; subthreshold MDD, 6·3%), of which about one-third were incident depressions in the period between baseline and follow-up. Depressive disorders rarely started before the age of 13. Females were about twice as likely as males to develop a depressive disorder. Overall, the 20-month outcome of baseline depression was unfavourable. Dysthymia had the poorest outcome of all, with a complete remission rate of only 33% versus 43% for MDD and 54% for subthreshold MDD. Dysthymia also had the highest number of depressive episodes, and most psychosocial impairment and suicidal behavioural during follow-up. Treatment rates were low (8–23%). Subthreshold MDD associated with considerable impairment had an almost identical course and outcome as threshold MDD. Conclusions. DSM-IV MDD and dysthymia are rare before the age of 13, but frequent during adolescence, with an estimated lifetime cumulative incidence of 14%. Only a minority of these disorders in adolescence is treated, and more than half of them persist or remit only partly.
Front-End Monitoring of the Mutual Inductance and Load Resistance in a Series–Series Compensated Wireless Power Transfer System

In this paper, a new method to estimate the mutual inductance and load resistance in a series-series compensated wireless power transfer system is presented. Reasonably accurate estimations can be obtained from measurements of the input voltage and current obtained at one operating frequency only. The proposal can be used to dynamically monitor both the coupling relationship between the transmitter and receiver coils and the load conditions without any direct measurement on the receiver side. It can also be used as a simple method to measure the mutual inductance of any pair of coupled coils. A novel impedance spectrum analysis method is further presented to show that series-series compensation has special characteristics in its input impedance spectrum. Experimental results with acceptable tolerance are included to show the effectiveness of the proposed method.
The NZM2410-derived lupus susceptibility locus Sle2c1 increases Th17 polarization and induces nephritis in fas-deficient mice.

OBJECTIVE Sle2 is a lupus susceptibility locus that has been linked to glomerulonephritis in the NZM2410 mouse. By itself, Sle2 does not induce any autoimmune pathology but results in the accumulation of B-1a cells. This study was designed to assess the contribution of Sle2 to the pathogenesis of autoimmunity. METHODS Sle2 or its subcongenic intervals (Sle2a, Sle2b, and Sle2c1) were bred to Fas-deficient B6.lpr mice. Lymphoid phenotypes, which were focused on T cells, were assessed by flow cytometry, and histopathologic changes were compared between cohorts of B6.Sle2. lpr congenic mice and B6.lpr mice of ages up to 6 months. RESULTS Sle2 synergized with lpr, resulting in a greatly accelerated lymphadenopathy that largely targeted T cells and mapped to the Sle2c1 locus. This locus has been identified as the main contributor to B-1a cell expansion. Further analyses showed that Sle2c1 expression skewed the differentiation and polarization of Fas-deficient T cells, with a reduction of the CD4+CD25+FoxP3+ regulatory T cell subset and an expansion of the Th17 cells. This was associated with a high number of T cell infiltrates that promoted severe nephritis and dermatitis in the B6.Sle2c1. lpr mice. CONCLUSION These results show that Sle2c1 contributes to lupus pathogenesis by affecting T cell differentiation in combination with other susceptibility loci, such as lpr. The significance of the cosegregation of this phenotype and B-1a cell expansion in Sle2c1-expressing mice in relation to the pathogenesis of lupus is discussed.
The Impact of Losing Your Job

of downward social mobility. Recent debates suggest that nowadays, workers face even greater risks on the labor market than before. Against this background, The Impact of Losing Your Job: Unemployment and Influences from Market, Family, and State on Economic Well-Being in the US and Germany provides an in-depth analysis of economic insecurity due to unemployment in the US and Germany. Building on life course sociology, it considers influences from market, family, and welfare state on the impact of losing a job. Household panel data has been used to analyze the occurrence of losing a job, its consequences, and the coping strategies found among the working-age population between the 1980s and the late 2000s. Both in the US and in Germany, economic insecurity due to losing a job is unevenly distributed among social strata. Groups that are already disadvantaged lose their jobs more often and have fewer private resources to cope with the loss. However, the German welfare state mitigates this disparity to a higher degree than its American counterpart. Yet, economic insecurity associated with risks on the labor market increased in Germany while we see no such trend in the US prior to the Great Recession.
Management of frontotemporal dementia in mental health and multidisciplinary settings

Abstract Diagnosis of frontotemporal dementia (FTD) in the mental health setting and issues pertaining to longitudinal care of this population in a specialist clinic are reviewed. FTD is often misdiagnosed as a psychiatric disorder, most commonly as a mood disorder. FTD has features that overlap with those of major depression, mania, obsessive–compulsive disorder and schizophrenia. We describe these features and how to differentiate FTD from these psychiatric disorders. This paper also describes practical issues in the management of FTD, specifically the issues that clinicians, patients and their families face in managing this disease. Areas of clinical care along the continuum are explored; FTD care involves collaborative management of symptoms and disability, and assisting patients and families in adapting to the disease.
Short-term carbon dynamics in a temperate grassland and heathland ecosystem exposed to 104 days of drought followed by irrigation

ABSTRACT Temperate ecosystems are susceptible to drought events. The effect of a severe drought (104 days) followed by irrigation on the plant C uptake, its assimilation and input of C in soil were examined using a triple 13CO2 pulse-chase labelling experiment in model grassland and heathland ecosystems. First 13CO2 pulse at day 0 of the experiment revealed much higher 13C tracer uptake for shoots, roots and soil compared to the second pulse (day 44), where all plants showed significantly lower 13C tracer uptake. After the third 13CO2 pulse (day 70), very low 13C uptake in shoots led to a negligible allocation of 13C into roots and soil. During irrigation after the severe drought, the 13C tracer that was allocated in plant tissues during the second and third pulse labelling was re-allocated in roots and soil, as soon as the irrigation started. This re-allocation was higher and longer lasting in heathland compared to grassland ecosystems.
Surgical Management of Moderate Sized Spontaneous Cerebellar Hematomas: Role of Intracranial Pressure Monitoring.

AIM Acute onset spontaneous cerebellar hematoma (SCH) is a neurosurgical emergency with unpredictable natural history and outcome. Specific guidelines are available for management of small ( < 2.5 cm) and large sized (4.0 cm < ) SCH. But, literature is sparse for treatment of moderate sized SCH (2.5-4.0 cm). MATERIAL AND METHODS In a retrospective analysis of 32 patients, with moderate sized acute SCH, external ventricular drainage (EVD) tube was inserted for evaluation of ICP and evacuation of cerebrospinal fluid. All patients with ICP > 25 mmHg underwent emergency SCH evacuation. Postoperatively, EVD was continued for 48-72 hours for ICP monitoring. Patients showing no improvement or persistent ventriculomegaly underwent ventriculoperitoneal shunt (VPS) insertion for the management of hydrocephalus. RESULTS 29/32 patients needed operative intervention either in the form of hematoma evacuation or shunt placement. 10 patients improved to GOS 5 and 7 to GOS 4. Overall mortality was 25% (n=8). Despite SCH evacuation, none of the patients with ICP > 40 mmHg experienced good outcome (p < 0.0001). CONCLUSION 47% of patients with moderate sized SCH need surgical evacuation. EVD insertion not only helps in ICP management but also includes the ability to gradually decompress ventricular system by varying the outflow pressure. Apart from radiologic findings, ICP measurement should be a guideline in management decisions.
Perceptual Sequence Learning Is More Severely Impaired than Motor Sequence Learning in Patients with Chronic Cerebellar Stroke

Patients with cerebellar stroke are impaired in procedural learning. Several different learning mechanisms contribute to procedural learning in healthy individuals. The aim was to compare the relative share of different learning mechanisms in patients and healthy controls. Ten patients with cerebellar stroke and 12 healthy controls practiced a visuomotor serial reaction time task. Learning blocks with high stimulus–response compatibility were exercised repeatedly; in between these, participants performed test blocks with the same or a different (mirror-inverted or unrelated) stimulus sequence and/or the same or a different (mirror-inverted) stimulus–response allocation. This design allowed to measure the impact of motor learning and perceptual learning independently and to separate both mechanisms from the learning of stimulus–response pairs. Analysis of the learning blocks showed that, as expected, both patients and controls improved their performance over time, although patients remained significantly slower. Analysis of the test blocks revealed that controls showed significant motor learning as well as significant visual perceptual learning, whereas cerebellar patients showed only significant motor learning. Healthy participants were able to use perceptual information for procedural learning even when the rule linking stimuli and responses had been changed, whereas patients with cerebellar lesions could not recruit this perception-based mechanism. Therefore, the cerebellum appears involved in the accurate processing of perceptual information independent from prelearned stimulus–response mappings.
Are Analyst Stock Recommendation Revisions More Informative in the Post‐IFRS Period?

This paper investigates whether the mandatory IFRS adoption has affected the informativeness of analyst recommendation revisions in Europe. Although prior studies document that IFRS adoption improved analyst forecast attributes, the impact of IFRS cannot be completely assessed without examining how the market reacts to informationâ€ rich events in an environment with enhanced disclosure. To examine this question we utilize a differenceâ€ inâ€ differences design using as main control sample firms that had voluntarily adopted IFRS before the EU's mandated switch. Overall, our evidence suggests that after the mandatory adoption of IFRS, both analyst upgrades and downgrades are more informative. These results hold after controlling for a number of variables that capture analyst, firm and information environment characteristics and are robust to a number of sensitivity analyses including the use of a US control sample. Finally, we examine whether our results are sensitive to the level of accounting enforcement. We find that analyst downgrades are more informative in the postâ€ IFRS period for firms in both high and low enforcement environments. Analyst upgrades, however, are more informative only if they are issued for firms in high enforcement countries.
Influence of lower limb pneumatic compression on pulmonary artery temperature: effect on cardiac output measurements.

OBJECTIVES To characterize the decreases in pulmonary artery temperature that coincide with the inflation cycle of pneumatic calf compression stockings and to examine their effects on the thermodilution measurement of cardiac output. DESIGN Three-part observational study. SETTING University hospital surgical intensive care unit. PATIENTS Postoperative patients with indwelling pulmonary artery catheters. INTERVENTION Thermodilution cardiac output measurements with and without pneumatic calf compression. MEASUREMENTS AND MAIN RESULTS Phase 1 (n = 18) examined the effects of pneumatic compression on pulmonary artery temperature. There was no effect on pulmonary artery temperature (device off, 37.468+/-0.008 degrees C; device on, 37.458+/-0.014 degrees C), but the difference between the maximum and minimum pulmonary artery temperatures was increased (off, 0.031+/-0.006 degrees C; on, 0.055+/-0.012 degrees C [p < .001]). Phase 2 (n = 12) found that the mean thermodilution cardiac output with 10 mL of cold (0-5 degrees C) injectate was unchanged by pneumatic compression (off, 7.00+/-2.28 L/min; on, 6.89+/-2.22 L/min). However, when the compression devices were operating, the variability between the individual measurements was increased, as reflected by larger coefficients of variation (off, 3.19+/-1.96; on, 8.72+/-6.56 [p < .02]). Similar results were obtained during phase 3 (n = 5), when cardiac output was measured with room temperature Injectate. CONCLUSIONS Intermittent pneumatic calf compression increased lower limb venous return, causing acute but transient decreases in pulmonary artery blood temperature. This did not affect the accuracy of thermodilution cardiac output measurements that were made using 10 mL of either cold or room temperature injectate.