Miracle-dz/UniFAR-FTUs huggingface dataset:
“Being Mindful”

Purpose: Feelings of excitement and relief upon finishing cancer treatment are often juxtaposed with a time that can be challenging, distressing, and uncertain for adolescents and young adults (AYAs). The purpose of this study was to examine whether a mindful dispositional trait was associated with better adaptive outcomes for these young people. Methods: AYAs who had finished cancer treatment (N = 76; mean age, 18.5; years, SD, 3.4 years) completed questionnaires measuring mindfulness, psychological distress, and uncertainty around their cancer experience. A median split was performed based on the total scores for the mindfulness measure to establish high and low mindfulness groups. Results: No significant differences were found between these 2 groups on demographic or cancer variables. There were significant differences between the groups on the distress and uncertainty scores such that the higher mindfulness group reported significantly less distress and uncertainty. Conclusions: The current findings suggest the potential for a broader application of mindfulness to more fully assist young people throughout the whole pathway of cancer care.
Effectiveness of Pharmacist-led Anticoagulation Management on Clinical Outcomes: A Systematic Review and Meta-Analysis.

OBJECTIVES We performed this systematic review and meta-analysis to confirm whether patients benefit more from pharmacist-led anticoagulation management than other models. METHODS We searched PubMed, Embase, Cochrane Library and reference lists of yielded results conducted up to April 25, 2017. RCTs and observational cohort studies and case-control studies which compared the percentage of time within the target therapeutic range (TTR), the percentage of time within the expanded therapeutic range (TER), haemorrhage events, thrombosis events, mortality, patient satisfaction and/or medicine cost saving of pharmacist-led anticoagulation management with other models, and species were limited to humans. Two investigators evaluated methodology and extracted data from included studies independently. Data analysis were performed by STATA 12.0 software and quality of evidence assessment was performed by GRADEprofiler software. RESULTS 8 RCTs and 9 observational cohort studies with 9919 patients were included eventually with high quality and no publication bias. In RCTs pooled results, TTR (p=0.548 moderate-quality), TER (p=0.285, moderate-quality), total haemorrhage events (p=0.140, low-quality), minor haemorrhage events (p=0.162, low-quality), major haemorrhage events (p=0.237, low-quality), thrombosis events (p=0.615, low-quality) and mortality (p=0.876, low-quality) was not significant between two groups. In observational studies pooled results, TTR (p=0.000, low-quality) was significant higher in pharmacist-led management group and the risk of total haemorrhage events (p=0.000, moderate-quality), minor haemorrhage events (p=0.000, moderate-quality) and thrombosis events (p=0.000, moderate-quality) were significant lower in pharmacist-led management group. Patient satisfaction and medicine cost saving were descriptively reviewed. CONCLUSIONS According to the grading of evidence, we concluded that the risk of total haemorrhage events, minor haemorrhage events and thrombosis events significantly decreased in pharmacist-led anticoagulation management group compared with other management models and no significant difference in TTR, TER, major haemorrhage events and mortality between two groups. Longer follow-up period RCT studies with large sample size should be done in the future to confirm effectiveness of pharmacist-led anticoagulation management model. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page.
Wearable ballistocardiography: Preliminary methods for mapping surface vibration measurements to whole body forces

The recent resurgence of ballistocardiogram (BCG) measurement and interpretation technologies has led to a wide range of powerful tools available for unobtrusively assessing mechanical aspects of cardiovascular health at home. Researchers have demonstrated a multitude of modern BCG measurement modalities, including beds, chairs, weighing scales, and wearable approaches. However, many modalities produce significant variations in the morphology of the measured BCG, creating confusion in the analysis and interpretation of the signals. This paper creates a framework for comparing wearable BCG measurements to whole body measurements - such as taken with a weighing scale system - to eventually allow the same analysis and interpretation tools that have been developed for whole body systems to be applied in the future to wearable systems. To the best of our knowledge, it represents the first attempt to morphologically compare vertical acceleration recordings measured on different locations on the torso to whole body displacements measured by BCG instrumentation.
Endothelium-Independent Relaxation of Vascular Smooth Muscle by 17β-Estradiol

Background: Estrogens directly dilate arteries, and this acute relaxation of vascular smooth muscle (VSM) may contribute to the cardioprotective effect of this important hormone. However, the mechanism by which estrogens relax VSM is not clear. Methods and Results: Based on observations in isolated smooth muscle cells, we hypothe sized that 17β-estradiol (E 2) causes dilation through receptor-mediated activation of K+ channels in VSM cells. To test this hypothesis, E2-relaxation was studied in arteries from male Sprague-Dawley rats. We observed that the estrogen receptor antagonist, tamoxifen (3 μmol) attenuated E2 relaxation, suggesting that at least a portion of the relaxation depends on activation of E2 receptors. The nitric oxide synthase inhibitor, Nω-nitro-L-arginine (100 μmol) did not affect E2 relaxation in either denuded or endothelium-intact arterial strips. Furthermore, inhibition of guanylyl cyclase with LY83583 (10 μmol) had no effect on the relaxation, suggesting that nitric oxide does not contribute to this relaxation. Vascular seg ments contracted with 90 mmol KCl to disrupt the K+ gradient had a similar E2 relaxation to segments contracted with phenylephrine (10 -6 mol/L) indicating that E2 relaxation does not require K+-channel activation. Finally, E2 pretreatment inhibited contraction of arterial segments depleted of intracellular calcium but in the presence of extracellular calcium. However, E2 did not affect contraction of strips in calcium-free solution. Conclusions: These final experiments suggest that E2 inhibits Ca2+ influx but not intracellu lar calcium release. Together, these studies establish that E2 causes receptor-mediated relax ation of peripheral resistance arteries through inhibition of calcium entry independent of nitric oxide production, guanylyl cyclase stimulation, and K+-channel activation.
4E10-Resistant Variants in a Human Immunodeficiency Virus Type 1 Subtype C-Infected Individual with an Anti-Membrane-Proximal External Region-Neutralizing Antibody Response

ABSTRACT The broadly neutralizing monoclonal antibody (MAb) 4E10 recognizes a linear epitope in the C terminus of the membrane-proximal external region (MPER) of gp41. This epitope is particularly attractive for vaccine design because it is highly conserved among human immunodeficiency virus type 1 (HIV-1) strains and neutralization escape in vivo has not been observed. Multiple env genes were cloned from an HIV-1 subtype C virus isolated from a 7-year-old perinatally infected child who had anti-MPER neutralizing antibodies. One clone (TM20.13) was resistant to 4E10 neutralization as a result of an F673L substitution in the MPER. Frequency analysis showed that F673L was present in 33% of the viral variants and in all cases was linked to the presence of an intact 2F5 epitope. Two other envelope clones were sensitive to 4E10 neutralization, but TM20.5 was 10-fold less sensitive than TM20.6. Substitutions at positions 674 and 677 within the MPER rendered TM20.5 more sensitive to 4E10 but had no effect on TM20.6. Using chimeric and mutant constructs of these two variants, we further demonstrated that the lentivirus lytic peptide-2 domain in the cytoplasmic tail affected the accessibility of the 4E10 epitope, as well as virus infectivity. Collectively, these genetic changes in the face of a neutralizing antibody response to the MPER strongly suggested immune escape from antibody responses targeting this region.
Stress analysis of endodontically treated teeth restored with post-retained crowns: A finite element analysis study.

BACKGROUND The authors conducted a study to analyze the stress concentration areas in a tooth restored with a post-retained crown under various conditions. MATERIALS AND METHODS The authors constructed a three-dimensional finite element model describing a maxillary second premolar restored with an all-ceramic crown supported by a titanium post and a resin-based composite core. They applied static vertical and horizontal loads of 100 newton to the cusp tip of the crown and recorded Von Mises and tensile stress values. The variables investigated were the presence of the post, coronal and apical post extensions, post diameter, post shape, and post and core material. RESULTS The study results showed that horizontal loading generated higher levels of stress than did vertical loading. The greatest stress levels were concentrated at the cervical region and at the post-dentin interface in all models. Under both loads, a higher modulus of elasticity of the post material and a wider post diameter were associated with increased stress values at the post-dentin interface. Reduction of the post extension above the level of bone was associated with increased dentinal stresses near the apex of the post. CONCLUSIONS Although endodontic posts provide retention for coronal restorations, they result in dentinal stress values higher than those of crowns without posts. Posts that had a similar modulus of elasticity to dentin and smaller diameters were associated with better stress distribution. Resting coronal restorations on sound dental tissues affected stress distribution more than did the core material or the length of the coronal post extension. CLINICAL IMPLICATIONS Many factors influence the distribution of stress within dentin and, consequently, the fracture resistance of teeth restored with post-retained crowns. Clinicians need to keep these factors in mind when performing endodontic procedures that involve placement of post-retained crowns to ensure optimal success.
Progress and new technologies for developing vaccines against gastrointestinal nematode parasites of sheep

Despite the identification of highly effective native antigens for vaccination against Haemonchus contortus, particularly ‘hidden’ antigens derived from the intestine of adult worms, to date similar efficacy has not been shown with recombinant antigens. In addition, progress towards identification of protective antigens from other sheep gastrointestinal (GI) nematode species is limited. Coupled with this is an incomplete understanding of the mechanism of natural immunity to GI nematodes, making selection of appropriate immunization strategies and adjuvants for evaluation of candidate ‘natural’ antigens problematic. The current explosion in new high‐throughput technologies, arising from human studies, for analysis of the genome, transcriptome, proteome and glycome offers the opportunity to gain a better understanding of the molecular pathways underlying pathogen biology, the host immune system and the host–pathogen interaction. An overview is provided on how these technologies can be applied to parasite research and how they may aid in overcoming some of the current problems in development of commercial vaccines against GI nematode parasites.
Pengaruh Intellectual Capital terhadap Kinerja Keuangan Perusahaan

T his study aims to analyze and provide empirical evidence of the influence of i ntellectual capital to company’s financial performance. Hypothesis (1) Intellectual Capital affect to company’s financial performance, (2) Intellectual Capital positively affect company’s financial performance for upcoming year. T his study uses secondary data to the entire population of banks and insurance companies listed in Indonesia Stock Exchange (IDX) 2011-2013. The method used to determine study sample was purposive sampling method, in order to obtain 114 sample companies, which each year is composed of 38 companies. The method of analysis used in this study is Partial Least Square (PLS). The result shows that intellectual capital have effect to company’s financial performance and company’s financial performance for upcoming year
Molecular Profiling: A Case of ZBTB16-RARA Acute Promyelocytic Leukemia

Several variant RARA translocations have been reported in acute promyelocytic leukemia (APL) of which the t(11;17)(q23;q21), which results in a ZBTB16-RARA fusion, is the most widely identified and is largely resistant to therapy with all-trans retinoic acid (ATRA). The clinical course together with the cytogenetic and molecular characterization of a case of ATRA-unresponsive ZBTB16-RARA APL is described. Additional mutations potentially cooperating with the translocation fusion product in leukemogenesis have been hitherto unreported in ZBTB16-RARA APL and were sought by application of a next-generation sequencing approach to detect those recurrently found in myeloid malignancies. This technique identified a solitary, low level mutation in the CEBPA gene. Molecular profiling of additional mutations may provide a platform to individualise therapeutic management in patients with this rare form of APL.
Immunogenicity of a Bovine Herpesvirus 1 Glycoprotein D DNA Vaccine Complexed with Bovine Neutrophil Beta-Defensin 3

ABSTRACT Protective efficacy against bovine herpesvirus 1 (BoHV-1) has been demonstrated to be induced by a plasmid encoding bovine neutrophil beta-defensin 3 (BNBD3) as a fusion construct with truncated glycoprotein D (tgD). However, in spite of the increased cell-mediated immune responses induced by this DNA vaccine, the clinical responses of BoHV-1-challenged cattle were not reduced over those observed in animals vaccinated with the plasmid encoding tgD alone; this might have been because the vaccine failed to improve humoral responses. We hypothesized that an alternative vaccine design strategy that utilized the DNA vaccine pMASIA-tgD as a complex with BNBD3 might improve humoral responses while maintaining robust Th1-type cell-mediated responses. C57BL/6 mice were vaccinated with pMASIA-tgD complexed with 0, 0.01875, 0.1875, or 1.875 nmol of a stable synthesized analog of BNBD3 (aBNBD3). The best results were seen in mice immunized with the vaccine composed of pMASIA-tgD complexed to 0.1875 nmol aBNBD3. In this group, humoral responses were improved, as evidenced by increased virus neutralization, tgD-specific early IgG1, and later IgG2a titers, while the strong cell-mediated immune responses, measured based on specific gamma interferon (IFN-γ)-secreting cells, were maintained relative to pMASIA-tgD. Modulation of the immune response might have been due in part to the effect of BNBD3 on dendritic cells (DCs). In vitro studies showed that murine bone marrow-derived DCs (BMDCs) pretreated with aBNBD3 were activated, as evidenced by CD11c downregulation, and were functionally mature, as shown by increased allostimulatory ability. Native, synthetic, and analog forms of BNBD3 were equally capable of inducing functional maturation of BMDCs.
Pollination induces autophagy in petunia petals via ethylene

Autophagy is one of the main mechanisms of degradation and remobilization of macromolecules, and it appears to play an important role in petal senescence. However, little is known about the regulatory mechanisms of autophagy in petal senescence. Autophagic processes were observed by electron microscopy and monodansylcadaverine staining of senescing petals of petunia (Petunia hybrida); autophagy-related gene 8 (ATG8) homologues were isolated from petunia and the regulation of expression was analysed. Nutrient remobilization was also examined during pollination-induced petal senescence. Active autophagic processes were observed in the mesophyll cells of senescing petunia petals. Pollination induced the expression of PhATG8 homologues and was accompanied by an increase in ethylene production. Ethylene inhibitor treatment in pollinated flowers delayed the induction of PhATG8 homologues, and ethylene treatment rapidly upregulated PhATG8 homologues in petunia petals. Dry weight and nitrogen content were decreased in the petals and increased in the ovaries after pollination in detached flowers. These results indicated that pollination induces autophagy and that ethylene is a key regulator of autophagy in petal senescence of petunia. The data also demonstrated the translocation of nutrients from the petals to the ovaries during pollination-induced petal senescence.
Childhood Aspirations, Occupational Outcomes and Exposure to Violence: Evidence from Burundi

Recent evidence points at the importance of childhood aspirations for our understanding of poverty and development. But how are these affected by the exposure to violence? This paper employs a logistic framework to study that question for Burundi, a conflict-affected, fragile state. Using data from a new nationwide survey with a panel component we distinguish between armed violence, domestic violence, violence at school and participation in violence. We find that (i) aspiring a job in the public sector is popular regardless of the type of violence; (ii) Children exposed to armed conflict have higher aspirations, defined as wishing to be employed outside of agriculture. Our results also show that these children, as well as children exposed to domestic violence, have a lower probability to fulfill their aspirations; (iii) children exposed to violence at school or children who perpetrated violence do not aspire to leave agriculture, making that their outcomes are closer to their aspirations, (iv) the differences between aspirations and outcomes for the four types of violence have a strong gender component.
Evaluation of nitric oxide as an inhibitory neurotransmitter in the equine ventral colon.

OBJECTIVE To determine the role of nitric oxide and an apamin-sensitive nonadrenergic noncholingeric inhibitory transmitter on contractility of the ventral colon of horses. SAMPLE POPULATION Strips of the circular and longitudinal muscle layers and taenia of the ventral colon from 14 horses. PROCEDURE Muscle strips were suspended in tissue baths and attached to force transducers. Contractile activity of circular, longitudinal, and taenia muscle strips in response to electrical field stimulation was measured after addition of apamin and a nitric oxide inhibitor, N-nitro-L-arginine methyl ester (L-NAME). RESULTS Electrical field stimulation reduced contractile activity in the circular muscle layer and taenia but not the longitudinal muscle layer. Addition of L-NAME significantly reduced inhibitory contractile activity at all frequencies for the circular muscle layer, whereas a significant effect was evident for the taenia only at the highest frequency. The combination of L-NAME and apamin resulted in a significant reduction in inhibition of the taenia at all frequencies but for circular muscle only at lower frequencies. CONCLUSIONS AND CLINICAL RELEVANCE Nitric oxide and an apamin-sensitive neurotransmitter appear to mediate a component of inhibitory transmission in the circular muscle and taenia, but not the longitudinal muscle layer, of the equine ventral colon. Nitric oxide has a role in regulating contractile activity of the equine ventral colon, and nitric oxide synthase inhibitors may be useful in horses with ileus of the large colon.
Firm capabilities, business model design and performance of SMEs

Purpose The purpose of this paper is to investigate the relationships between firm capabilities, business model (BM) design, and firm performance. Design/methodology/approach The study provides a quantitative assessment of the proposed model using a sample of 411 small- and medium-sized enterprises. Heckman’s sample selection model is employed as an econometric framework. Findings The outcomes demonstrate that the adoption of a given BM is endogenous with respect to firm capabilities, different capabilities spur the adoption of different BM, and that different BM designs have variable impacts on firm performance. Research limitations/implications Some investigated variables were operationalized using proxies, and firm performance was measured based on a self-assessed scale. Practical implications Since different types of capabilities are at the bases of different BM designs that eventually reverberate on firm performance, SMEs should carefully balance their financial resources invested in the development of capabilities. Originality/value This study represents one of the first attempts to investigate the relationships between firm capabilities, BM design, and firm performance.
Amino acid interaction preferences in proteins

Understanding the key factors that influence the interaction preferences of amino acids in the folding of proteins have remained a challenge. Here we present a knowledge‐based approach for determining the effective interactions between amino acids based on amino acid type, their secondary structure, and the contact based environment that they find themselves in the native state structure as measured by their number of neighbors. We find that the optimal information is approximately encoded in a 60 × 60 matrix describing the 20 types of amino acids in three distinct secondary structures (helix, beta strand, and loop). We carry out a clustering scheme to understand the similarity between these interactions and to elucidate a nonredundant set. We demonstrate that the inferred energy parameters can be used for assessing the fit of a given sequence into a putative native state structure.
Nurses as providers of support for mothers of premature infants.

AIM The study aims to explore the supportive behaviour of nurses as experienced by mothers of premature infants in Hong Kong. BACKGROUND The sudden, unexpected delivery of a premature infant is an extreme shock to parents. Studies have confirmed the importance of nursing support to the relief of stress of parents. DESIGN A descriptive study design. METHODS A convenience sampling of 37 mothers in a neonatal Intensive Care Unit were recruited from a regional hospital to complete the 'Nurses Parent Support Tool' (NPST) which consists of four aspects: communication information support, emotional support, parental esteem support and quality care-giving support. Six mothers were interviewed after the completion of the tool to give examples of supportive and non-supportive behaviour. RESULTS The results showed that all of the mothers rated all nursing support items as important. However, there was a significant mean difference between perceived and received nursing support. These findings demonstrated that parents desired more nursing support than they received, particularly in the area of supportive communication and the giving of information. Comparatively, emotional support was rated less important as well as having been less often received than the other three domains of support. Interviews with six mothers further gave examples and described the types, attributes and the phases of support in the Chinese setting. CONCLUSION The findings indicate that Chinese parents are desirous of more nursing support than they received. RELEVANCE TO CLINICAL PRACTICE Nurses should be aware of the importance of tailoring nursing support to meet the needs of parents of premature infants.