Miracle-dz/UniFAR-FTUs huggingface dataset:
VALUE-ADDED ENTERPRISE, CORPORATE GOVERNANCE ON SUSTAINABLE ENTERPRISE WITH INVESTMENT OPPORTUNITIES SET ASINTERVENING VARIABLE

This study was to analyze the causes of the company can be sustained. The company can not survive, internal problems:value-added enterprise is bad and no good corporate governance.External factorscould be expected to affect the sustainable enterprise in global economic crisis.The sample used a public company listed on the Indonesia Stock Exchange (IDX) and New York Stock Exchange (NYSE). The result is a significant influence investment opportunities set for sustainable enterprise, corporate governance significantly affect indirectly on sustainable enterprise through a set of investment opportunities, and value-added companies significantly affect indirectly on sustainable enterprise through a set of investment opportunities. The implication of government need to provide ease to the entrepreneurs to invest in order to enterprise sustainability, so as to open up a broader jobs and increase revenue for the state through taxation sector.
Binding-Site Interactions between Epstein-Barr Virus Fusion Proteins gp42 and gH/gL Reveal a Peptide That Inhibits both Epithelial and B-Cell Membrane Fusion

ABSTRACT Herpesviruses require membrane-associated glycoproteins gB, gH, and gL for entry into host cells. Epstein-Barr virus (EBV) gp42 is a unique protein also required for viral entry into B cells. Key interactions between EBV gp42 and the EBV gH/gL complex were investigated to further elucidate their roles in membrane fusion. Deletion and point mutants within the N-terminal region of gp42 revealed residues important for gH/gL binding and membrane fusion. Many five-residue deletion mutants in the N-terminal region of gp42 that exhibit reduced membrane fusion activity retain binding with gH/gL but map out two functional stretches between residues 36 and 96. Synthetic peptides derived from the gp42 N-terminal region were studied in in vitro binding experiments with purified gH/gL and in cell-cell fusion assays. A peptide spanning gp42 residues 36 to 81 (peptide 36-81) binds gH/gL with nanomolar affinity, comparable to full-length gp42. Peptide 36-81 efficiently inhibits epithelial cell membrane fusion and competes with soluble gp42 to inhibit B-cell fusion. Additionally, this peptide at low nanomolar concentrations inhibits epithelial cell infection by intact virus. Shorter gp42 peptides spanning the two functional regions identified by deletion mutagenesis had little or no binding to soluble gH/gL and were also unable to inhibit epithelial cell fusion, nor could they complement gp42 deletion mutants in B-cell fusion. These studies identify key residues of gp42 that are essential for gH/gL binding and membrane fusion activation, providing a nanomolar inhibitor of EBV-mediated membrane fusion.
Consumer Acceptance of Cloud Computing

ABSTRACT To date, little research has focused on the consumer's perspective of cloud computing acceptance. Thus, this article explores the drivers of voluntary consumer acceptance of cloud computing in a sample of Moroccan students. Results indicate that in addition to ease of use and perceived usefulness, structural trust is important for voluntary cloud computing acceptance. However, unlike prior studies, results indicate that perceived ease of use has a stronger effect on intention to use cloud computing, than perceived usefulness. The results of this study contribute to theory and provide strategies for cloud computing service providers to attract and retain individual consumers.
Cytoplasmic Forms of Human T-Cell Leukemia Virus Type 1 Tax Induce NF-κB Activation

ABSTRACT Human T-cell leukemia virus type 1 (HTLV-1) Tax targets I-κBα and I-κBβ for phosphorylation, ubiquitination, and proteasome-mediated degradation, causing the nuclear translocation of NF-κB/Rel proteins and transcription induction of many cellular genes. The mechanism by which a nuclear protein such as Tax stimulates I-κB phosphorylation and degradation remains unclear. Here, we describe two cytoplasmic mutants of Tax, designated TaxΔN81 and TaxΔN109, from which the domains important for cyclic AMP response element binding factor (CREB) and serum response factor (SRF) binding and nuclear transport have been removed. These mutants were unable totrans activate from the HTLV-1 21-bp repeats or the serum response element in the c-fos promoter. In contrast, they activated NF-κB reporters, suggesting that activation of NF-κB by Tax occurs in the cytoplasm. Incorporation of the nuclear localization signal (NLS) of the simian virus 40 large T antigen into TaxΔN81 and TaxΔN109 redirected both proteins predominantly to the nucleus yet did not restore trans activation via CREB or SRF. The NLS fusion had little effect on TaxΔN81 but reduced NF-κBtrans activation by TaxΔN109, possibly because of its proximity to the NF-κB-activating domain of Tax. In contrast to wild-type Tax, the cytoplasmic TaxΔN mutants are not cytotoxic. Stable expression of TaxΔN109 in HeLa cells resulted in a significant reduction in the intracellular level of I-κBα, with the constitutive presence of NF-κB in the nucleus and concomitant activation of the NF-κB enhancer. These results are suggestive of a potential application of the TaxΔN109-like mutants in targeting I-κB degradation and NF-κB activation. Interestingly, a Tax species with a molecular mass similar to that of TaxΔN109 was identified in many HTLV-1-transformed T cells, suggesting that TaxΔN109-like species might play a role in HTLV-1-induced leukemogenesis.
Pengaruh Intellectual Capital Terhadap Profitabilitas, Produktivitas, Dan Nilai Perusahaan Pada Perusahaan Perbankan Yang Terdaftar Di Bursa Efek Indonesia (BEI)

This study tested the influence of intellectual capital to profitability, productivity, and value of the company. In this research intellectual capital divided into human capital and structural capital. Intellectual capital was measured using Value Added Intellectual Coefficient (VAIC). Profitability, was measured by Return On Assets (ROA) and the Return on Equity (ROE). Productivity, was measured by Assets Turn Over (ATO), and Tobin's Q for company value. Object of the study were 27 banking company which are listed on the Indonesia stock exchange between 2010 to 2012. Research results show that intellectual capital has positive impact to profitability (ROA and ROE), but no significant effect on the productivity and value of the company. The possibility of companies in Indonesia still largely use the conventional approach, not based on knowledge intensive high tech firms and lack of attention to human capital, structural capital, and customer capital.
Increased Rate of Multiple-Bit Upset From Neutrons at Large Angles of Incidence

Neutron interactions with terrestrial systems produce soft errors, increasing the failure-in-time (FIT) rate of advanced CMOS circuits. These neutron-induced errors are a critical reliability problem facing advanced technologies. This paper reports the accelerated neutron testing on a 90-nm CMOS SRAM that exhibits an increased multiple-bit upset FIT rate from neutrons at large angles of incidence. The modeling of these data is used to predict the reliability of ground-based systems.
Perilaku Knowledge Sharing: Anteseden dan Pengaruhnya Terhadap Kemampuan Inovasi Individual

Purpose of this research was to analyze effects of organizational climate, organizational citizenship behavior, and social capital on knowledge sharing behavior. This research also analyzed effect of knowledge sharing behavior on individual innovation capability. Sample was 58 employees of BPR. Data was taken using questionnaires and analyzed using path analysis of linear regression. Result showed that only organizational climate and social capital affected knowledge sharing behavior. Result also showed that knowledge sharing behavior affected individual innovation capability.
The Domain of a Point Set Surface

It is useful to be able to define a two-dimensional point-set surface determined by a point cloud. One popular definition is Levin's MLS surface. This surface is defined on a domain which is a three-dimensional subset of R3, a narrow region around the input point cloud. If we were to extend the definition outside the domain, we would produce components of the surface which are far from the point cloud. This is important in practice, since when moving points onto the MLS surface, we need to begin with an initial guess which is within the domain. We visualize the domain in two dimensions, and explain why it is so narrow. We also consider two MLS variants which can be defined on a wider domain without producing spurious surface components. One is efficient and works well except near sharp corners. The other is computationally expensive but seems to work well everywhere.
Peripheral arterial disease, prevalence and cumulative risk factor profile analysis

Background: The primary aim of the present study was to determine the cumulative effect of a set of peripheral artery disease (PAD) risk factors among age, gender and race/ethnicity groups in the United States. Methods: We examined data from a nationally representative sample of the US population (National Health and Nutrition Examination Survey [NHANES], 1999–2004). A total of 7058 subjects 40 years or older that completed the interview, medical examination and had ankle–brachial index (ABI) measurements were included in this study. Results: The age- and sex-standardized prevalence of PAD was 4.6 % (standard error [SE] 0.3%). The highest prevalence of PAD was observed among elderly, non-Hispanic Blacks and women. In a multivariable age-, gender- and race/ethnicity-adjusted model hypertension, diabetes, chronic kidney disease, and smoking were retained as PAD risk factors (p ≤ 0.05 for each). The odds of PAD increased with each additional risk factor present from a non-significant 1.5-fold increase (O.R 1.5, 95% confidence interval [CI] 0.9–2.6) in the presence of one risk factor, to more than ten-fold (OR 10.2, 95% CI 6.4–16.3) in the presence of three or more risk factors. In stratified analysis, non-Hispanic Blacks (OR 14.7, 95% CI 2.1–104.1) and women (OR 18.6, 95% CI 7.1–48.7) were particularly sensitive to this cumulative effect. Conclusion: In a large nationally representative sample, an aggregate set of risk factors that included diabetes mellitus, chronic kidney disease, hypertension and smoking significantly increase the likelihood of prevalent PAD. A cumulative risk factor analysis highlights important susceptibility differences among different population groups and provides additional evidence to redefine screening strategies in PAD.
The More, the Better?! Multiple vs. Single Jobholders’ Job Satisfaction as a Matter of Lacked Information

In recent decades, the working world has changed dramatically and rising demands on flexibility make the coordination of personal and professional life more difficult. Therefore, it is important that the incumbents are in possession of all necessary information concerning their job. This might be a key issue to remain satisfied. Simultaneously, atypical forms of employment have substantially increased in the labor market; one such form is holding more than one job. While the motives might differ from needing an additional income to broadening job opportunities, practicing several jobs requires coordination and thus, being informed. Building on research regarding organizational constraints and role ambiguity, we hypothesize that the paucity of information is negatively related to (dimensions of) job satisfaction. This effect should be stronger for multiple as compared to single jobbers; specifically when considering the job satisfaction with the social climate, given that being informed by others is an important factor in the coordination of several jobs. Data taken from the BiBB/BAuA-Employment-Survey provide a sample of 17,782 German employees (54% women), including 1,084 multiple jobbers (59% women). Job satisfaction was measured as employees global satisfaction and their satisfaction with facets dimensions: the social climate, structural working conditions, personal growth opportunities, and material incentives they receive for their work. Paucity of information was measured by the frequency of lacked information. Our study indicated that paucity of information was negatively related to both, global and all facets dimensions of job satisfaction. Multiple regression analyses further revealed interaction effects of paucity of information and form of employment. Specifically, the negative correlation of paucity of information with global as well as satisfaction with the social climate was stronger for employees’ holding more than one job. These results were independent of age, gender, organizational tenure, working hours, socioeconomic occupational status, as well as important working conditions (workload and autonomy). Incumbents with less paucity of necessary job-related information are more satisfied, especially when they hold multiple jobs. Supervisors and colleagues are advised to provide all necessary information and to ensure that employees retain it.
Pharmacology and clinical experience with risperidone

Risperidone (Risperdal®, Janssen Pharmaceutica) is a second generation antipsychotic (SGA) for the treatment of schizophrenia and other psychotic disorders. It is a potent antagonist of serotonin-2 (5-HT2) and dopamine-2 (D2) receptors in the brain. In comparison to conventional antipsychotics, risperidone demonstrates superior efficacy against the positive and negative symptoms of schizophrenia and a decreased occurrence of extrapyramidal side effects (EPS). Risperidone causes less weight gain than other marketed SGAs, but can increase prolactin levels and cause EPS in a dose-related manner. In a variety of pharmacoeconomic analyses, it has proven to be a cost-effective addition to the antipsychotic armamentarium. As the first SGA available for front line use, risperidone has established a new standard of care for the treatment of individuals with psychotic disorders.
Immunofluorescence Detection of F-actin on Low Melting Point Wax Sections from Plant Tissues

We developed a simple and reliable technique for immunofluorescence detection of F-actin on microtome sections of plant tissues. For the first time, large numbers of plant cells from various tissues that pass through their developmental stages could be consistently visualized on one section from plant organs. n-Maleimidobenzoic acid N-hydroxy-succinimide ester-pretreated and formalin-fixed segments of plant roots and shoots were embedded in low melting point ester wax at 37C and sectioned on a microtome. After dewaxing and rehydration, microfilaments were visualized by indirect immunofluorescence technique with a monoclonal anti-actin antibody. The technique has been successfully used for visualization of tissue- and development-specific F-actin arrays in cells of Zea mays and Lepidium sativum root tips and of maize stem nodes.
Immunodeficiency and Autoimmunity in 22q11.2 Deletion Syndrome

22q11.2 deletion syndrome is the commonest chromosome deletion syndrome. 22q11.2 deletion may result in variable clinical phenotypes which may differ even between patients with identical deletions. Abnormal pharyngeal arch development results in defects in the development of the parathyroid glands, thymus and conotruncal region of the heart. Defective thymic development is associated with impaired immune function. ‘Complete’ DiGeorge syndrome with total absence of the thymus and a severe T‐cell immunodeficiency accounts for <0.5% of patients. The majority of patients with 22q11.2 deletion syndromes have ‘partial’ defects with impaired thymic development rather than complete absence with variable defects in T‐cell numbers. Immunodeficiency in these patients is not solely due to T‐cell deficiency and abnormalities of T‐cell clonality or impairment of proliferative responses may play a role. Humoral deficiencies including defects in the B‐cell compartment have also been identified in these patients. 22q11.2 deletion syndrome patients are at increased risk of a variety of autoimmune diseases. A number of immune defects may predispose to the development of autoimmunity in these patients including increased infection, impaired development of natural T‐regulatory cells and impaired thymic central tolerance.
Yolanda Pico MATRIX EFFECTS IN QUANTITATIVE PESTICIDE ANALYSIS USING LIQUID CHROMATOGRAPHY – MASS SPECTROMETRY

W.M.A. Niessen,* P. Manini, and R. Andreoli hyphen MassSpec, de Wetstraat 8, 2332 XT Leiden, the Netherlands Department of Analytical Chemistry and Applied Spectroscopy, Faculty of Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands Laboratory of Industrial Toxicology, Department of Clinical Medicine, Nephrology and Health Sciences, University of Parma, via Gramsci 14, 43100 Parma, Italy
Ecotypic differences in the phenology of the tundra species Eriophorum vaginatum reflect sites of origin

Abstract Eriophorum vaginatum is a tussock‐forming sedge that contributes significantly to the structure and primary productivity of moist acidic tussock tundra. Locally adapted populations (ecotypes) have been identified across the geographical distribution of E. vaginatum; however, little is known about how their growth and phenology differ over the course of a growing season. The growing season is short in the Arctic and therefore exerts a strong selection pressure on tundra species. This raises the hypothesis that the phenology of arctic species may be poorly adapted if the timing and length of the growing season change. Mature E. vaginatum tussocks from across a latitudinal gradient (65–70°N) were transplanted into a common garden at a central location (Toolik Lake, 68°38′N, 149°36′W) where half were warmed using open‐top chambers. Over two growing seasons (2015 and 2016), leaf length was measured weekly to track growth rates, timing of senescence, and biomass accumulation. Growth rates were similar across ecotypes and between years and were not affected by warming. However, southern populations accumulated significantly more biomass, largely because they started to senesce later. In 2016, peak biomass and senescence of most populations occurred later than in 2015, probably induced by colder weather at the beginning of the growing season in 2016, which caused a delayed start to growth. The finish was delayed as well. Differences in phenology between populations were largely retained between years, suggesting that the amount of time that these ecotypes grow has been selected by the length of the growing seasons at their respective home sites. As potential growing seasons lengthen, E. vaginatum may be unable to respond appropriately as a result of genetic control and may have reduced fitness in the rapidly warming Arctic tundra.
Role of SraP, a Serine-Rich Surface Protein of Staphylococcus aureus, in Binding to Human Platelets

ABSTRACT The binding of bacteria to platelets is a postulated central event in the pathogenesis of infective endocarditis. Platelet binding by Streptococcus gordonii is mediated in large part by GspB, a high-molecular-mass cell wall glycoprotein. Although Staphylococcus aureus has a GspB homolog (SraP), little is known about its function. SraP has a calculated molecular mass of 227 kDa and, like GspB, is predicted to contain an atypical N-terminal signal sequence, two serine-rich repeat regions (srr1 and srr2) separated by a nonrepeat region, and a C-terminal cell wall anchoring motif (LPDTG). To assess whether SraP contributes to platelet binding, we compared the binding to human platelets of S. aureus strain ISP479C and of an isogenic variant (strain PS767) in which sraP had been disrupted by allelic replacement. Platelet binding in vitro by PS767 was 47% ± 17% (mean ± standard deviation) lower than that of ISP479C (P < 0.001). In addition, a recombinant fragment of SraP containing srr1 and the nonrepeat region was found to bind platelets directly. Binding was saturable, suggesting a receptor-ligand interaction. When tested in a rabbit model of endocarditis, in which each animal was simultaneously infected with ISP479C and PS767 at a ratio of approximately 1:1, the titers of the mutant strain within vegetations were significantly lower than those of the parent strain at 1 and 24 h postinfection. These results indicate that SraP can mediate the direct binding of S. aureus to platelets and that the platelet-binding domain of this glycoprotein is located within its N-terminal region. Moreover, the expression of SraP appears to be a virulence determinant in endovascular infection.
Business-to-business relationships as a source for advertising success

This thesis project was initiated in the autumn of 2012 to particularly look into the area of business-to-business relationships in the context of the advertising industry. In particular, the focus being to research this aspect from the view of different advertising mediums. The motivation for this stemmed from the idea of various B2B studies existing on a general level, while specific studies into B2B relationships and their impact on advertising effectiveness do not exist, particularly from the viewpoint of different advertising channels. In order to tap into this gap, this study incorporated advertising mediums from print and tablet advertising. This was done due to the novelty and increasing importance of tablet advertising and the possibility to compare it to more traditional advertising channels (i.e. newspaper and magazine advertising). Following the notions rising from the literature, the research set particular focus on existing B2B taxonomy study by Cannon and Perreault (1999) and sought out to adapt the featured scales into advertising industry context. The research was based on a survey that tested the relationships depending on the mediums and reviewed their impacts on advertising effectiveness. The survey was sent out to the largest companies in Finland by revenue with 46 fulfilled responses arising high-level decision makers, such as CEOs, Marketing Directors/Managers and other relevant personnel. For the analysis, the study utilized qualitative comparative analysis (QCA) and its fuzzy-set variant that make it possible to implement the positive aspects of qualitative analysis over more than a handful of cases. In addition, the method includes quantitative, empirical foundation and thus overall provides for scientifically viable results through configurations that lead to an outcome. Using this method, the research determined that there are notable differences between the advertising mediums, when considering relation-specific details that lead to advertising campaigns to succeed. Highly prioritized print media mediums were more prone to be used in a lesscooperative manner, whereas the lower prioritized tablet advertising was sought to succeed with tight cooperative actions between the advertiser and the provider. Thus, for decision makers in the advertising industry, it can be useful to be aware of the perceived factors that lead to success (e.g. whether to share proprietary information) and how these are dependent on the advertising medium. In the case of advertising providers, it can be seen equally as important to react accordingly to these perceptions to build successful relationships between the parties that yield value and success. This research was seen to tap into these issues and as such provide for both managerial and theoretical implications.
Public Equity Markets and Innovation

This paper reviews the literature on the role of public equity markets in the innovation ecosystem. The review highlights the importance of public equity markets in funding the research and development activities of young and high growth firms. It also illustrates the dependence of venture capital firms, which provide an important source of capital to earlystage start-ups, on the performance of public equity markets and the initial public offering market in particular. Finally, the paper discusses the potential shortcomings of public equity markets that may hinder innovation, and highlights various mechanisms that may alleviate such concerns.