Miracle-dz/UniFAR-FTUs huggingface dataset:
On the Robustness of Multiscale Indices for Long-Term Monitoring in Cardiac Signals

The identification of patients with increased risk of Sudden Cardiac Death (SCD) has been widely studied during recent decades, and several quantitative measurements have been proposed from the analysis of the electrocardiogram (ECG) stored in 1-day Holter recordings. Indices based on nonlinear dynamics of Heart Rate Variability (HRV) have shown to convey predictive information in terms of factors related with the cardiac regulation by the autonomous nervous system, and among them, multiscale methods aim to provide more complete descriptions than single-scale based measures. However, there is limited knowledge on the suitability of nonlinear measurements to characterize the cardiac dynamics in current long-term monitoring scenarios of several days. Here, we scrutinized the long-term robustness properties of three nonlinear methods for HRV characterization, namely, the Multiscale Entropy (MSE), the Multiscale Time Irreversibility (MTI), and the Multifractal Spectrum (MFS). These indices were selected because all of them have been theoretically designed to take into account the multiple time scales inherent in healthy and pathological cardiac dynamics, and they have been analyzed so far when monitoring up to 24 h of ECG signals, corresponding to about 20 time scales. We analyzed them in 7-day Holter recordings from two data sets, namely, patients with Atrial Fibrillation and with Congestive Heart Failure, by reaching up to 100 time scales. In addition, a new comparison procedure is proposed to statistically compare the poblational multiscale representations in different patient or processing conditions, in terms of the non-parametric estimation of confidence intervals for the averaged median differences. Our results show that variance reduction is actually obtained in the multiscale estimators. The MSE (MTI) exhibited the lowest (largest) bias and variance at large scales, whereas all the methods exhibited a consistent description of the large-scale processes in terms of multiscale index robustness. In all the methods, the used algorithms could turn to give some inconsistency in the multiscale profile, which was checked not to be due to the presence of artifacts, but rather with unclear origin. The reduction in standard error for several-day recordings compared to one-day recordings was more evident in MSE, whereas bias was more patently present in MFS. Our results pave the way of these techniques towards their use, with improved algorithmic implementations and nonparametric statistical tests, in long-term cardiac Holter monitoring scenarios.
Computer Simulation Studies of a Kainate (GluK1) Receptor with Two Glutamate Analogues

Unprecedented advancements have been achieved to understand the underlying mechanisms that sustain life. The modulation of these mechanisms, especially in disease conditions, could lead to the development of new medical applications. However, to attain this goal, we need to characterize life processes at the molecular level. Unfortunately, the majority of current experimental techniques used in life sciences lack this resolution. In this work, we have used molecular dynamics, a computational “microscopy”, to gain insight into the mechanism of interaction, at the atomic level, between two bicyclic glutamate analogues with the ligand–binding domain (LBD) of a kainate receptor 1 (GluK1). This protein receptor plays a crucial role in the development of various central nervous system (CNS) disorders such as Alzheimer’s disease, epilepsy and depression. Here we report the outcome of Molecular Dynamics (MD) simulations to calculate the affinity of binding of two ligands, the glutamate analogues LM-12b and CIP-AS, toward the LBD of GluK1 (GluK1–LBD) and to unravel, at the atomic level, the structural dynamics of such interactions. Our computational approach not only was capable of ranking correctly the binding affinity of analyzed ligands toward the protein receptor, but also to reveal, at atomic resolution, the dynamic nature of such ligand–LBD interaction. Our studies showed that the methyl group of LM-12b is crucial to stabilize structurally the LBD pocket. In contrast, the LBD–CIP-AS complex lacked this interaction, which may explain its weaker affinity. Revealing the structural and dynamics bases that underlie the mechanism of ligand–kainate receptor interaction may ultimately drive the identification of new modulators aimed at the treatment of CNS disorders.
Optimal Short Cycle Decomposition in Almost Linear Time

Short cycle decomposition is an edge partitioning of an unweighted graph into edge-disjoint short cycles, plus a small number of extra edges not in any cycle. This notion was introduced by Chu et al. [FOCS’18] as a fundamental tool for graph sparsiﬁcation and sketching. Clearly, it is most desirable to have a fast algorithm for partitioning the edges into as short as possible cycles, while omitting few edges. The most naïve procedure for such decomposition runs in time O ( m · n ) and partitions the edges into O (log n )-length edge-disjoint cycles plus at most 2 n edges. Chu et al. improved the running time considerably to m 1+ o (1) , while increasing both the length of the cycles and the number of omitted edges by a factor of n o (1) . Even more recently, Liu-Sachdeva-Yu [SODA’19] showed that for every constant δ ∈ (0 , 1] there is an O ( m · n δ )-time algorithm that provides, w.h. p., cycles of length O (log n ) 1 /δ and O ( n ) extra edges. In this paper, we signiﬁcantly improve upon these bounds. We ﬁrst show an m 1+ o (1) -time deterministic algorithm for computing nearly optimal cycle decomposition, i.e., with cycle length O (log 2 n ) and an extra subset of O ( n log n ) edges not in any cycle. This algorithm is based on a reduction to low-congestion cycle covers , introduced by the authors in [SODA’19]. We also provide a simple deterministic algorithm that computes edge-disjoint cycles of length 2 1 /(cid:15) with n 1+ (cid:15) · 2 1 /(cid:15) extra edges, for every (cid:15) ∈ (0 , 1]. Combining this with Liu-Sachdeva-Yu [SODA’19] gives a linear time randomized algorithm for computing cycles of length poly (log n ) and O ( n ) extra edges, for every n -vertex graphs with n 1+1 /δ edges for some constant δ . These decomposition algorithms lead to improvements in all the algorithmic applications of Chu et al. as well as to new distributed constructions.
Decontamination methods to restore the biocompatibility of contaminated titanium surfaces

Purpose The reaction of cells to a titanium implant depends on the surface characteristics of the implant which are affected by decontamination. The aim of this study was to evaluate the cytocompatibility of titanium disks treated with various decontamination methods, using salivary bacterial contamination with dental pellicle formation as an in vitro model. Methods Sand-blasted and acid-etched (SA) titanium disks were used. Three control groups (pristine SA disks [SA group]; salivary pellicle-coated SA disks [pellicle group]; and biofilm-coated, untreated SA disks [NT group]) were not subjected to any decontamination treatments. Decontamination of the biofilm-coated disks was performed by 14 methods, including ultrasonic instruments, rotating instruments, an air-powder abrasive system, a laser, and chemical agents. MG63 cells were cultured in the presence of the treated disks. Cell proliferation assays were performed on days 2 and 5 of cell culture, and cell morphology was analyzed by immunofluorescence and scanning electron microscopy (SEM). A vascular endothelial growth factor (VEGF) assay was performed on day 5 of culture. Results The cell proliferation assay revealed that all decontaminated disks, except for the 2 groups treated using a plastic tip, showed significantly less cell proliferation than the SA group. The immunofluorescence and SEM analyses revealed that most groups showed comparable cell density, with the exception of the NT group, in which the cell density was lower and bacterial residue was observed. Furthermore, the cells grown with tetracycline-treated titanium disks showed significantly lower VEGF production than those in the SA group. Conclusions None of the decontamination methods resulted in cytocompatibility similar to that of pristine SA titanium. However, many methods caused improvement in the biocompatibility of the titanium disks in comparison with the biofilm-coated, untreated titanium disks. This suggests that decontamination is indispensable for the treatment of peri-implantitis, even if the original biocompatibility cannot be restored.
A retrospective comparison of induction with thiopental/guaifenesin and propofol/ketamine in Thoroughbred racehorses anesthetized with sevoflurane and medetomidine during arthroscopic surgery

ABSTRACT This study compares clinical characteristics between induction with thiopental/guaifenesin and propofol/ketamine in Thoroughbred racehorses anesthetized with sevoflurane and medetomidine. Clinical records of 214 horses that underwent arthroscopic surgery between 2015 and 2016 were retrospectively retrieved. Horses were premedicated with medetomidine and midazolam to sedate at the adequate level for smooth induction, and then induced with either thiopental (4.0 mg/kg) and guaifenesin (100 mg/kg) in Group TG (n=91) or propofol (1.0 mg/kg) and ketamine (1.0 mg/kg) in Group PK (n=123). Anesthesia was maintained using sevoflurane with constant rate infusion of medetomidine. Quality of induction/recovery, sevoflurane requirement, cardiovascular function and recovery characteristics were evaluated. Anesthetic induction scores (median, range) for Group TG (5, 2–5) and Group PK (5, 2–5) were not significantly different. There were no significant differences in end-tidal sevoflurane concentration (mean ± standard deviation) between Group TG and Group PK (both 2.4 ± 0.2%). Dobutamine infusion rate (µg/kg/min) required for keeping mean arterial blood pressure (MAP) above 70 mmHg in Group PK (0.43, 0.10–1.40) was significantly lower than in Group TG (0.67, 0.08–1.56). Recovery score in Group PK (5, 2–5) was significantly higher than in Group TG (4, 2–5). Both propofol/ketamine and thiopental/guaifenesin provided a smooth induction of anesthesia. Moreover, induction with propofol/ketamine resulted in lower dobutamine requirements for keeping MAP above 70 mmHg during maintenance, and better quality of recovery. Induction with propofol/ketamine would be preferable to thiopental/guaifenesin in Thoroughbred racehorses anesthetized with sevoflurane and medetomidine during arthroscopic surgery.
Up-regulation of PCOLCE by TWIST1 promotes metastasis in Osteosarcoma

Procollagen C-proteinase enhancer protein (PCOLCE) was originally identified as an enhancer to facilitate the catalysis of procollagens by BMP1. PCOLCE participates in the reconstitution of extracellular and corneal repair. The elevation of PCOLCE in blood indicates that breast cancer has metastasized into the bones. However, direct research on PCOLCE has not been reported. Methods: ECM candidates were identified by RNA-seq analysis from 4 normal and 16 osteosarcoma tissues. The in vitro migration and invasion abilities of osteosarcoma cells were determined by a Transwell assay. A spontaneous metastatic osteosarcoma model was established to assess osteosarcoma metastasis in vivo. The N-linked glycosylated amino acids were identified by PNGase F treatment combined with Western blotting. The mechanism of TWIST1 regulating PCOLCE transcription was elucidated by luciferase, qPCR and ChIP assays. Results: PCOLCE was markedly up-regulated in human osteosarcoma tissues compared to its expression in noncancerous adjacent tissues; high PCOLCE expression in tissues correlated with a poor patient prognosis, and the knockdown of PCOLCE by shRNAs impaired the migration, invasion and lung metastasis of osteosarcoma cells. The overexpression of wild-type PCOLCE, but not its N29Q mutant, promoted migration, invasion and metastasis, indicating that the glycosylation of PCOLCE at Asn29 is necessary for its functions in osteosarcoma. TWIST1, a key transcription factor in metastasis, was also overexpressed in osteosarcoma tissues and positively correlated with either PCOLCE or its potential procollagen substrates, such as COL1A1, COL1A2, COL5A1, COL8A2 and COL10A1. Conclusion: Our findings are the first to provide evidence that PCOLCE plays a critical role in promoting the lung metastasis of osteosarcoma, and this up-regulation of PCOLCE by TWIST1 may lead to a new therapeutic strategy to treat patients with metastatic osteosarcoma.
Surgical corrections and postsurgical complications of epiglottic entrapment in Thoroughbreds: 12 cases (2009–2015)

ABSTRACT Twelve Thoroughbred racehorses were diagnosed as epiglottic entrapment at the Korea Racing Authority equine hospital. Four different surgical correction techniques were used to treat epiglottic entrapment: the transnasal hook bistoury, transoral unshielded hook bistoury, transnasal shielded hook bistoury, and transendoscopic laser techniques. Eleven cases were surgically resolved eventually, with one case of recurrence. Five complications related to surgical correction occurred: a severe nasal passage laceration and bleeding (n=1), epiglottic laceration (n=1), epiglottis tip burns (n=2), and moderate nasal passage laceration (n=1). Intraoperative complications occurred in approximately 41.7% of cases. Thus, the possibility of surgical complication should be considered thoroughly when choosing a surgical technique for correction of epiglottic entrapment.
Emergent Repair of Paraesophageal Hernias and the Argument for Elective Repair

Background and Objectives: A feared complication of large paraesophageal hernias is incarceration necessitating emergent repair. According to previous studies, patients who require an emergent operation are subject to increased morbidity compared with patients undergoing elective operations. In this study, we detail patients who underwent hernia repair emergently and compare their outcomes with elective patients. Methods: A retrospective analysis was performed of the paraesophageal hernia repair operations between 2010 and 2016. Patients were divided into 2 groups: patients with hernias that were repaired electively and patients with hernias that were repaired emergently. Perioperative complications and follow-up data regarding morbidity, mortality, and recurrence were also recorded. A propensity analysis was used to compare emergent and elective groups. Results: Thirty patients had hernias repaired emergently, and 199 patients underwent elective procedures. Patients undergoing emergent repair were more likely to have a type IV hernia, have a partial gastrectomy or gastrostomy tube insertion as part of their procedure, have a postoperative complication, and have a longer hospital stay. However, propensity analysis was used to demonstrate that when characteristics of the emergent and elective groups were matched, differences in these factors were no longer significant. Having an emergent operation did not increase a patient's risk for recurrence. Conclusion: Patients who had their hernias repaired emergently experienced complications at similar rates as those of elective patients with advanced age or comorbid conditions as demonstrated by the propensity analysis. The authors therefore recommend evaluation of all paraesophageal hernias for elective repair, especially in younger patients who are otherwise good operative candidates.
The Position of the Popliteal Artery and Peroneal Nerve Relative to the Menisci in Children: A Cadaveric Study

Background: Meniscal injury in skeletally immature patients is increasingly reported. During meniscal repair, all-inside devices may protrude beyond the posterior limits of the meniscus, putting the neurovascular structures at risk. Purpose: The purposes of this study were (1) to examine the relationship between the popliteal artery and the posterolateral and posteromedial aspects of the menisci, (2) to examine the relationship of the peroneal nerve to the posterolateral meniscus, and (3) to develop recommendations for avoiding neurovascular injury during posterior meniscal repair in pediatric patients. Study Design: Descriptive laboratory study. Methods: A total of 26 skeletally immature knee cadaveric specimens (7 females and 19 males) were included. Specimens were divided into age groups: 2-4, 5-8, and 9-11 years. The most posterior extent of the lateral and medial menisci was identified via sagittal and axial views on computed tomography (CT) scans. The shortest distance from the most posterior aspect of the lateral and medial menisci to the popliteal artery and the shortest distance from the posterior aspect of the lateral menisci to the anterior rim of the peroneal nerve were measured, and 3-dimensional models of representative specimens were re-created through use of CT scans. Results: For the age groups 2-4, 5-8, and 9-11 years, the mean minimum distance from the posterolateral meniscus to the popliteal artery was 5.2, 6.7, and 8.2 mm, respectively, and the mean minimum distance from the posteromedial meniscus to the popliteal artery was 12.7, 15.4, and 20.3 mm, respectively. In all groups, the distance between the posteromedial meniscus and the popliteal artery was greater than that between the posterolateral meniscus and the popliteal artery. The mean distance from the peroneal nerve to the lateral meniscus was 13.3, 15.0, and 17.9 mm for the respective groups. Conclusion: Many all-inside meniscal repair devices have sharp tips that penetrate posterior to the meniscus and capsule. This study demonstrated that the distance between the posterior meniscus and popliteal artery is relatively small in pediatric patients, especially for the lateral meniscus region. Clinical Relevance: Because of the higher potential for meniscal healing, meniscal repair is more likely to be performed in pediatric patients. The data in this study regarding the proximity of the lateral meniscus and neurovascular structures may be used to guide safe surgical repair of posterior meniscal tears during the use of all-inside meniscal repair devices in these patients.
Determinants of the use of food product information by female workers in Nigerian state universities

This study examined the influence of demographic characteristics, perception of food risks and health information literacy on the use of food product information among 561 female staff in eight State Universities in Nigeria. Descriptive statistics and binary logistic regression were used to analyze the data. The findings revealed that age, perceived risks and health information literacy were the factors that influence the use or non-use of food product information among the respondents. Women who are above 50 years are more likely to use food product information in consumption decisions than younger women. Furthermore, the respondents showed high perception of food risks; however, about half of them have optimistic bias towards the hazards of eating unwholesome packaged foods. The study therefore recommends that the National Agency for Food and Drug Administration and Control (NAFDAC) embark on aggressive awareness campaigns on the health hazards associated with eating unwholesome packaged food, targeting younger female workers in Nigerian State Universities. Public health experts, librarians and other information professionals should also embark on enlightenment programmes for the public and the academic community. This study complements an earlier study which examined the use of various types of food product information in consumption of packaged foods among the same population.
Neural network models in EMG diagnosis

In previous years, several computer-aided quantitative motor unit action potential (MUAP) techniques were reported. It is now possible to add to these techniques the capability of automated medical diagnosis so that all data can be processed in an integrated environment. In this study, the parametric pattern recognition (PPR) algorithm that facilitates automatic MUAP feature extraction and Artificial Neural Network (ANN) models are combined for providing an integrated system for the diagnosis of neuromuscular disorders. Two paradigms of learning for training ANN models were investigated, supervised, and unsupervised. For supervised learning, the back-propagation algorithm and for unsupervised learning, the Kohonen's self-organizing feature maps algorithm were used. The diagnostic yield for models trained with both procedures was similar and on the order of 80%. However, back propagation models required considerably more computational effort compared to the Kohonen's self-organizing feature map models. Poorer diagnostic performance was obtained when the K-means nearest neighbor clustering algorithm was applied on the same set of data. >
THE CCAUV.A-K3 KEY COMPARISON OF PRESSURE RECIPROCITY CALIBRATION OF LS2P MICROPHONES: RESULTS AND ANALYSIS

The CCAUV.A-K3 Key Comparison has involved 15 countries organized in two loops with two common laboratories, CENAM and DPLA. The measurements took place in 2003. This is the first CCAUV key comparison organized with more than one loop, and therefore the analysis of the results required a more elaborated method to arrive to the desired degrees of equivalence per laboratory and between any pair of laboratories. An implementation of the linear least squares has been applied to the analysis of the CCAUV.A- K3 key comparison. In this paper, the mathematical development is presented in parallel with the results of the comparison. The details of the analysis are reviewed, and suggestions are made in order to further improve comparison protocols in acoustics.
The development of basic reading skills in children: a cross-language perspective

This chapter reviews recent empirical evidence for universal and orthography- or language-specific processes in the development of basic reading skills in school age children, suggesting that universal and orthography- or language-specific processes should be considered in tandem. The review focuses on three different aspects of reading, phonological processing, rapid naming, and morphosyntactic complexity, targeted in recent research on development of word recognition skills. Studies on L1 school children and studies of children who learn to read concurrently in their L1 and/or in a second language (L2) are examined within the context of variations in orthographic transparency. When children learn to read, characteristics of the spoken language interact with characteristics of the orthography. The chapter concludes that (a) individual differences in phonological processing skills, verbal memory, and rapid naming predict the development of reading in L1 and L2 children in various alphabetic and nonalphabetic languages; and (b) individual differences on such prerequisite skills can indicate smooth or problematic acquisition of L2 reading skills in children, regardless of oral language proficiency. However, task demands associated with learning to read in different orthographies vary and yield steeper or more moderate learning slopes. Regardless of the language and orthography combinations under study, children can develop reading strategies that help them read.