Miracle-dz/UniFAR-FTUs huggingface dataset:
Intracardiac hemodynamics in man during short periods of head-down and head-up tilt.

The intracardiac hemodynamic responses to short periods of 70 degrees head-down and head-up tilts were studied in 12 normal male subjects, ages 19-24 years. Echo-Doppler techniques were used to measure the transmitral and transaortic flow velocities as well as cardiac index, and to evaluate the peripheral impedance. Head-down tilt (HDT) rapidly induced an increase (9.7%, p < 0.05) in the early passive filling of the left ventricle (ME peak of the transmitral flow velocity curve) and in transaortic flow velocity (8%, p < 0.05), as well as in cardiac output (6%, p < 0.05). In spite of a peripheral vasodilation, the blood pressure increased (7%, p < 0.05 for the systolic; 15%, p < 0.01 for the diastolic) and remained at a high level for the 5 min of the experiment. Head-up tilt (HUT) induced inverse responses; i.e., a large initial decrease in the transmitral (-15%, p < 0.05) and transaortic (-16%, p < 0.001) flows. The shape of the arterial peripheral flow indicated an increased vascular impedance. After a short drop, the blood pressure rapidly recovered a level statistically close to that of the pretest. In both cases, tachycardia occurred. We conclude that, in man, the cardiac responses to the changes in posture appear to be related more to the passive changes in ventricular filling due to the blood shift than to the nervous regulation by the arterial baroreflexes, whereas these reflexes mainly act in the control of the vascular impedance.
Cold Turkey vs. gradualism: Evidence on disinflation strategies from a laboratory experiment

Disinflation can be implemented gradually or via Cold Turkey - an immediate change of policy - with the latter being mainly recommended by theory and empirical literature. But Cold Turkey may only be superior because it is endogenously selected for favorable environments. To eliminate this endogeneity and to disentangle the credible push through of a disinflation policy from ex-ante credibility, I run an experiment where a central banker has to decide for a disinflationary strategy and four forecasters try to coordinate on it. The design abstracts from any rigidities and provides full information so that Cold Turkey is the Nash equilibrium. But Cold Turkey fails to be the most successful strategy because forecasters react sluggishly due to limited reasoning. Cold Turkey does not speed up learning or increase reasoning, is less successful and is reversed more often.
Variability in rate of cervical dilation in nulliparous women at term.

BACKGROUND Cervical dilatation is commonly documented on a partogram indicating the expected rate of progress of labor. Although deviations from such a line can be used to indicate abnormal progress, what constitutes the "normal" rate of cervical dilation is still largely unknown. The objectives of this study were to assess the variability of the rate of cervical dilation in nulliparous women and to determine whether the rate of labor was independent of dilation on admission. METHODS We analyzed a cohort of consecutive nulliparous women with spontaneous labor at term and singleton fetuses in cephalic presentation. Exclusion criteria were gestational age less than 37 weeks, induction of labor, or the presence of a uterine scar. Management of labor was standardized using set protocols of care. Active labor was diagnosed as regular contractions every 10 minutes or less, lasting more than 40 seconds, with cervical effacement more than 80 percent and dilation of 2 cm. Vaginal examinations were performed by a dedicated midwife every 2 hours. Amniotomy was performed for slow progress or arrest of dilation over 2 hours. Oxytocin was administered for arrest of cervical dilation for 2 hours with membranes ruptured. Data pertaining to cases ending in cesarean delivery were included up to the time of cesarean section. RESULTS The study sample comprised 1,119 women at 39.7 ± 1.1 weeks with an average duration of labor of 4.1 ± 2.4 hours. The rate of oxytocin use was 27 percent and of epidural analgesia 5 percent. The rate of oxytocin use was inversely related to cervical dilation on admission. Cesarean delivery was performed in 6 percent of women. Duration of labor at each centimeter of cervical dilation on admission showed a broad distribution (e.g., at 4 cm: median = 5.5, range: 0.8-12.5 hr). The rate of labor progression (expressed as the slope of the dilation-vs-time curve) was approximately 1.5 cm/hr, and it was essentially independent of cervical dilation on admission (r = 0.034, p = 0.267). A deceleration phase seemed to be present toward the end of the active phase of labor (approximately 9 cm). CONCLUSION In our setting, the rate of labor in nulliparous women at term was highly variable, and it did not appear to be affected by cervical dilation on admission.
Using the Eating Disorder Examination in the Assessment of Bulimia and Anorexia

ABSTRACT Objective: The Eating Disorder Examination will be assessed according to its reliability and validity in the assessment of anorexia nervosa and bulimia nervosa. Method: A thorough review of the literature was conducted to judge the reliability and validity of the Eating Disorder Examination and its subscales. Results: The review shows that the EDE and its subscales have good interrater reliability and internal consistency reliability. Similarly, high levels of discriminant validity, construct validity, and treatment validity in the assessment of eating disorders were also found. A summary of each study concerning the various types of reliability and validity will be provided. Conclusions: The EDE is considered to be the “gold standard” by which to identify eating disorders, so this tool used in conjunction with other behavioral measures will be imperative for clinical social work practice.
The limitations of activation policies: unemployment at the end of working life

ABSTRACT In several European countries, older unemployed people, after reaching a certain age, are entitled to unemployment benefit payments without having to seek new employment. The coexistence of this exemption clause and of reforms aimed at containing early retirement in the respective countries reflects a conflict of political aims – on the one hand, between an efficient labour-market policy at a time of high unemployment, and on the other hand, the goal of the comprehensive activation and labour-market integration of older workers as a response to demographic change. This paper deals with the reasons for the transfer of older long-term unemployed people on to ‘facilitated benefits’ for labour-market withdrawal in Germany. The empirical analysis shows that low or no propensity to work was rarely the motive for leaving the labour market; in particular, those anticipating a low retirement income actually wanted to be re-employed. The vast majority gave three reasons for the decision to retire: an inability to cope with requirements of available jobs; a lack of job opportunities; and an absence of proper support from the public employment agency. Thus the withdrawal of older long-term unemployed people into pre-retirement cannot be attributed to a utility-maximising decision in favour of leisure and against gainful employment, but is the primary result of the scarce re-employment prospects.
EML4-ALK Fusion Is Linked to Histological Characteristics in a Subset of Lung Cancers

Introduction: Very recently, we have found a novel fusion product between the echinoderm microtubule-associated protein-like4 (EML4) and the anaplastic lymphoma kinase (ALK) in non-small cell lung cancers (NSCLCs). Tumors featuring EML4-ALK fusion constitute one subtype of NSCLC that might be highly sensitive to ALK inhibitors. Herein, we present results of a first large scale study of EML4-ALK fusion in lung cancers. Methods: Using reverse transcription-polymerase chain reaction for EML4-ALK fusion mRNA, we investigated 149 lung adenocarcinomas, 48 squamous cell carcinomas, 3 large-cell neuroendocrine carcinomas, and 21 small-cell carcinomas. For EML4-ALK-positive cancers, we further investigated the presence of ALK fusion proteins by immunohistochemistry. Results: Five of 149 adenocarcinomas (3.4%) showed EML4-ALK fusion mRNA, this being totally lacking in carcinomas of other types (0/72). In all the fusion-positive cases, ALK fusion protein could be detected in the cytoplasm immunohistochemically. The five fusion cases featured two EML4-ALK variant 1 fusions and three variant 2 fusions. Histologically, both variant 1 cases were mixed type adenocarcinomas, showing papillary with bronchioloalveolar components. Interestingly, all three variant 2 cases were acinar adenocarcinomas, the link being statistically significant (p = 0.00018). None of the five fusion-positive cases demonstrated any mutations of EGFR or KRAS, pointing to a mutually exclusive relationship (p = 0.014). There was no association with smoking habits. Conclusions: In the present first investigation of EML4-ALK fusion in a large study of lung cancers (5/221), we found an interesting histotype-genotype relationship. Furthermore, we could detect the fusion protein by immunohistochemistry, pointing to possible clinical applications.
MODELING CHOLERA DYNAMICS WITH CONTROLS

In this paper, we present and analyze a cholera epidemiological model with control measures incorporated. This model is extended from the one proposed in [16] by including the effects of vaccination, therapeutic treatment, and water sanitation. Equilibrium analysis is conducted in the case with constant controls for both epidemic and endemic dynamics. Optimal control theory is applied to seek cost-effective solution of multiple time-dependent intervention strategies against cholera outbreaks.
Role of nitrogen supplementation in alleviating drought-associated growth and metabolic impairments in Phoebe zhennan
 seedlings

Drought is one of the major environmental stresses altering forest productivity. However, nutrient availability can modulate drought resistance. Phoebe zhennan (gold Phoebe) is a high‐quality timber‐producing but threatened tree species in China, facing serious anthropogenic disturbances and abiotic constraints that restrict its growth and development. However, little attention has been given to designing adaptive strategies for its management by evaluating the possible role of major nutrients, particularly nitrogen (N), on its morphological and physio‐biochemical responses under water stress. To evaluate these responses, a complete randomized design was followed to investigate the effects of two irrigation levels (well‐watered and drought‐stressed conditions) and N fertilization treatments (with and without N). Drought stress significantly affected the growth of seedlings, as indicated by impaired photosynthesis, pigment degradation, disrupted N metabolism, over‐production of reactive oxygen species and enhanced lipid peroxidation. Nitrogen supplementation under drought stress had remarkable positive effects on the growth through physio‐biochemical adjustments as shown by higher level of nitrogenous compounds and up‐regulation of N‐associated metabolic enzymes activities which might be due to N‐mediated improved leaf relative water contents and photosynthetic efficiency. In addition, N application reduced oxidative stress and membrane damage, and maintained a high accumulation of osmolytes. However, in well‐watered seedlings N fertilization significantly improved root biomass and net CO₂ assimilation rate suggesting high N‐use efficiency of the seedlings. These findings reveal that drought significantly affects the growth of P. zhennan, while N fertilization plays a crucial role in alleviating water stress damage by improving its drought tolerance potential at low metabolic costs. Therefore, N fertilization could be considered as an effective strategy for the conservation and management of P. zhennan in the face of future climate change.
Specific DNA Recognition by F Factor TraY Involves β-Sheet Residues*

The F Factor TraY protein is a sequence-specific DNA-binding protein required for efficient conjugal transfer. Genetic and biochemical studies indicate that TraY has two functional roles in conjugation. TraY binds to the PY promoter to up-regulate transcription of tra genes. TraY also binds to the plasmid origin of transfer (oriT), serving as an accessory protein in the nicking of F Factor in preparation for transfer. TraY is thought to belong to the ribbon-helix-helix family of transcription factors. These proteins contact DNA using residues of an antiparallel β-sheet. We engineered and characterized six TraY mutants each having a single potential β-sheet DNA contact residue replaced with Ala. Most TraY mutants had significantly reduced affinity for the TraY oriT binding site while possessing near wild-type stability and nonspecific DNA recognition. These results indicate that TraY β-sheet residues participate in DNA recognition, and support inclusion of TraY in the ribbon-helix-helix family.
Pathogenesis of osteoporosis in liver cirrhosis.

BACKGROUND/AIMS Osteoporosis has been recognized in patients with liver cirrhosis, although the prevalence and the exact mechanisms vary considerably in the literature. We have studied the prevalence of bone disease in cirrhotic patients, the pathogenesis and the relation to the etiology and the severity of liver failure. METHODOLOGY The study included 83 hospitalized patients with various types of cirrhosis, where 25 healthy individuals served as controls. Patients were classified according to Child-Pugh's stages as follows: Child A: 49, Child B: 20, Child C: 14. Serum levels of iPTH, 250HD, LH, FSH, SHBG, testosterone, estradiol, IGF-I, osteocalcin and urine levels of cross-linked N-telopeptides of collagen type 1 (NTX) were measured in all patients. Bone mineral density (BMD) was measured by DEXA at the spine of both patients and controls. RESULTS The prevalence of osteoporosis was higher in patients (26/83) 31.3% than in controls (4/25) 16%. Osteopenia was positively related with the elevated levels of crosslinked N-telopeptides (p=0.048). There were no differences in BMD between the types of cirrhosis. BMD was found to be significantly lower in Child B and C male patients than in Child A (p=0.043). Patients' groups B, and C had lower testosterone levels with a trend to contribute to the low BMD (p=0.15). 250HD and IGF-1 were significantly lower in decompensated cirrhosis (p<0.002), but did not correlate with BMD. CONCLUSIONS Cirrhosis is a major cause of osteoporosis and the degree of osteopenia is related to the severity and not the etiology of the liver disease. The biochemical markers of bone remodeling suggest a high-turnover osteoporosis in cirrhosis.
Willingness to use mobile technologies for data collection in a probability household panel

We asked members of the Understanding Society Innovation Panel about their willingness to participate in various data collection tasks on their mobile devices. We find that stated willingness varies considerably depending on the type of activity involved: respondents are less willing to participate in tasks that involve downloading and installing an app, or where data are collected passively. Stated willingness also varies between smartphones and tablets, and between types of respondents: respondents who report higher concerns about the security of data collected with mobile technologies and those who use their devices less intensively are less willing to participate in mobile data collection tasks.
Trajectory planning for reaching an object on a table using accumulated action data

This paper describes a robot trajectory planning method for grasping an object placed on a table. In conventional methods, the more obstacles are on the table, the more calculation costs are needed to find a course for avoiding the obstacles; to overcome this problem we use Accumulated Action Data from previous situations. The Action Data is composed of obstacles arrangement and manipulation trajectory and the manipulator acts on the information that is decided by comparing data arrangement with the present arrangement. For evaluating this method, we performed experiments in different conditions on a simulator.
Effects of Gatifloxacin and Levofloxacin on Rates of Hypoglycemia and Hyperglycemia Among Elderly Hospitalized Patients

Study Objectives. To compare rates of hypoglycemia and hyperglycemia among elderly hospitalized patients with normal blood glucose concentrations at baseline who were receiving either gatifloxacin or levofloxacin, and to determine if appropriateness of their doses, according to their package inserts, was associated with hypoglycemia or hyperglycemia.
Immersion in the bureaucratic field: Methodological pathways

Abstract The introduction argues that while the legitimacy of bureaucracy as an object of inquiry is well established, little is generally said on the methodologies mobilized by ethnographers to study the bureaucratic field. The special issue is a contribution to fill this gap. The authors characterize bureaucracy as a mode of control by way of four dimensions—service, rule, violence, and secrecy—and propose three methodological pathways through which ethnographers may immerse in the bureaucratic field. The first pathway, “stages,” is concerned with the methodological reflections on accessing the bureaucratic stage and of being led in by bureaucrats as they perform their stage work. The second focuses on “techniques” and considers the implications of immersing oneself in a distinct technical landscape. The third pathway concerns the ethnographer’s positionality, drawing attention to the deep reflexivity and unstable ethics of bureaucracy ethnography. The authors invite bureaucracy ethnographers to pursue these pathways and to engage in a critical reflection on their fieldwork practices.
Interferon-beta is more potent than interferon-alpha in inhibition of human hepatocellular carcinoma cell growth when used alone and in combination with anticancer drugs.

BACKGROUND The prognosis of advanced hepatocellular carcinoma (HCC) is extremely poor, but promising effects of chemotherapies combined with interferon (IFN) have been reported. METHODS To develop more effective combination therapies for HCC, we compared the antiproliferative effects of IFN-alpha and IFN-beta in combination with various cytotoxic drugs on hepatoma cell lines using MTT assay and isobologram analysis. RESULTS IFN-beta was more potent than IFN-alpha in inhibiting the cell growth of all cell lines (P <.05, two-way ANOVA). PLC/PRF/5 was more sensitive to either IFN, than HLE and HuH7. Cell growth of all cell lines was inhibited in a dose-dependent manner by 5-fluorouracil (5-FU), cisplatin (CDDP), and doxorubicin (DOX), but the sensitivities of these cells were considerably different. As for IFN-alpha, synergistic effects were observed when combined with 5-FU and DOX on PLC/PRF/5 cells only, whereas IFN-beta showed synergistic effects with 5-FU and CDDP on HuH7 and PLC/PRF/5 cell lines. CONCLUSION The spectra of the antiproliferative activity and synergistic effect of IFN-beta when combined with anticancer drugs are more potent than those of IFN-alpha. Combinations of IFN-beta and anticancer drugs may provide a better treatment of HCC when combinations with IFN-alpha are ineffective.
FAKTOR-FAKTOR YANG MEMPENGARUHI OPINI AUDIT GOING CONCERN

This research enhances and examine about the effect of audit tenure, company growth, firm size, KAP’s reputation, opinion shopping, and the previous audit opinion towards audit going concern opinion. The sample of this research is obtainable by using the purposive sampling method by focusing on manufacture companies that has been listed on the Indonesia Stock Exchange, 2010-2013. Samples were obtained as many as 12 companies by the number of observations is 48 sample. Data analysis techniques used in this research is the logistic regression analysis techniques. Based on the analysis results it is revealed that the audit tenure, company growth negative affect towards the going concern audit opinion. KAP’s reputation and opinion shopping positive affect towards the going concern audit opinion. Therefore, the firm size and previous audit opinion doesn’t seet to affect towards the going concern audit opinion.
Psychosocial aspects of dental and general fears in dental phobic patients

Phobic reactions can often be a significant health problem for fearful dental patients. This is true in particular for individuals with long-time avoidance and elevated general psychological distress. The aim of this study was to investigate the expression of dental fear among 67 dental phobic individuals with a low versus high degree of general fear. Reported etiologic background factors, avoidance time, general psychological distress and psychosocial manifestations and consequences of dental phobia were studied. No significant difference in dental anxiety level between individuals with low versus high general fear was found, and both groups reported high frequencies of negative dental experiences. The low-fear group reported a longer (though not statistically significant) average avoidance time than the high-fear group. However, patients with a high level of general fear showed a significantly higher degree of psychological distress, and also reported stronger negative social consequences from their dental anxiety. These results indicate that the character of dental fear might be different between different groups of fearful patients, which makes the condition psychologically handicapping. Such aspects should be assessed in the diagnostic analysis of patients with severe dental anxiety. In particular, assessments of signs of general psychological distress are warranted.
Clairvoyant and adaptive signal detection in non-Gaussian clutter: a data-dependent threshold interpretation

This paper addresses the problem of signal detection in correlated non-Gaussian clutter modeled as a spherically invariant random process. The optimum strategy to detect a constant signal, with either known or unknown complex amplitude, embedded in correlated Gaussian clutter is given by comparing the whitening-matched filter output with a fixed threshold. When the clutter is non-Gaussian, the performance of the matched filter sensibly degrades. The optimum strategy is the classical whitening-matched filter output compared with a data-dependent threshold. This interpretation provides a deeper insight into the structure of the optimum detector and allows us to single out a family of suboptimum detectors based on a polynomial approximation of the data-dependent threshold. They are easy to implement and have performance that is really close to the optimal. The adaptive implementation of the polynomial detectors is also investigated, and their performance is analyzed by means of Monte Carlo simulation for various clutter scenarios.