Miracle-dz/UniFAR-FTUs huggingface dataset:
Development of a Safe and Pragmatic Awake Craniotomy Program at Maine Medical Center

Background Awake craniotomy offers an excellent means of performing intraoperative mapping and optimizing surgical resection of brain tumors. Awake craniotomy relies on a strong collaboration between anesthesiologists, neurosurgeons, and operating room staff. The authors recently introduced awake craniotomy for tumor resection at the Maine Medical Center and propose that it can be performed safely, effectively, and efficiently in a high-volume community hospital. Methods We describe a practical approach to performing awake craniotomy involving streamlined anesthetic protocols and simplified intraoperative testing parameters in a carefully selected group of patients. Our first 25 patients are retrospectively reviewed with particular attention to the anesthetic protocol, the extent of resection, the operative time, post-operative complications, the length of hospitalization, and their functional status at follow-up. Results The authors established an anesthetic protocol based primarily on midazolam, fentanyl, propofol, and local anesthetic. The authors note that all but one patient was able to tolerate the awake procedure. Gross total resection was achieved in nearly 80% of patients with a glial tumor. Operative time was short, averaging 159 minutes of entire anesthesia care. Length of stay averaged 3.7 days. Persistent new post-operative deficits were noted in 2 of 25 patients. There was no substantial difference in total hospital charges for patients undergoing awake craniotomy when compared to a matched historical control. Conclusions With attention focused on patient selection and a streamlined anesthetic protocol, the authors were able to successfully implement an awake craniotomy protocol in a community setting with satisfying results, including low operative morbidity, short operative times, low anesthetic complications, and excellent patient tolerance.
Responses to ustekinumab in the anti‐TNF agent‐naïve vs. anti‐TNF agent‐exposed patients with psoriasis vulgaris

Background Approximately 20–30% of patients with psoriasis treated with anti‐tumour necrosis factor α (TNFα) agents will discontinue treatment within 2 years due to loss of efficacy or side‐effects. Switching to another anti‐TNFα agent produces clinical responses inferior to previously untreated patients. Ustekinumab binds to the p40 subunit of interleukin (IL)‐12 and IL‐23 and provides a mechanism of action independent of TNFα.
Emotional Intolerance and Core Features of Anorexia Nervosa: A Dynamic Interaction during Inpatient Treatment? Results from a Longitudinal Diary Study

Objective The role of emotion dysregulation with regard to the psychopathology of anorexia nervosa (AN) is increasingly discussed. It is both assumed that AN symptoms have an impact on difficulties in tolerating aversive emotions and that—conversely—emotion dysregulation influences AN. To date, such conclusions are drawn on the basis of cross-sectional data not allowing for inferences on the temporal dynamics. The current study investigates the longitudinal interaction between emotional intolerance and core AN symptoms over the course of inpatient treatment by comparing patients with high (BMI<15 kg/m2) vs. low symptom severity (HSS vs. LSS). Method The study adopted a longitudinal, process-oriented design with N = 16 analysed electronic diaries. Throughout the course of their inpatient treatment, the patients answered questions daily about emotional intolerance and their AN-specific cognitions and behaviours. The temporal dynamics between emotional intolerance and these variables were analysed using a multivariate time series approach. Results The time series of the processes under investigation adequately reflected the individual treatment courses. The majority of significant linear time trends was found for HSS patients. Most importantly, analysis revealed significant temporal interactions between emotional intolerance and AN symptoms in almost 70% of HSS patients. Thereby, up to 37% of variance in eating restraint and up to 23% in weight concern could be attributed to changes in emotional intolerance. Conclusions The findings support the notion that intolerable unpleasant emotions in severely affected AN patients influence their psychopathology. Additionally, time series analysis outlined the inter-individual heterogeneity of psychosomatic treatment courses of AN patients.
Representing object categories by connections: Evidence from a mutivariate connectivity pattern classification approach

The representation of object categories is a classical question in cognitive neuroscience and compelling evidence has identified specific brain regions showing preferential activation to categories of evolutionary significance. However, the potential contributions to category processing by tuning the connectivity patterns are largely unknown. Adopting a continuous multicategory paradigm, we obtained whole‐brain functional connectivity (FC) patterns of each of four categories (faces, scenes, animals and tools) in healthy human adults and applied multivariate connectivity pattern classification analyses. We found that the whole‐brain FC patterns made high‐accuracy predictions of which category was being viewed. The decoding was successful even after the contributions of regions showing classical category‐selective activations were excluded. We further identified the discriminative network for each category, which span way beyond the classical category‐selective regions. Together, these results reveal novel mechanisms about how categorical information is represented in large‐scale FC patterns, with general implications for the interactive nature of distributed brain areas underlying high‐level cognition. Hum Brain Mapp 37:3685–3697, 2016. © 2016 Wiley Periodicals, Inc.
Taxometric Investigation of Depression: Evidence of Consistent Latent Structure Across Clinical and Community Samples

Objective: Past taxometric studies of depression have yielded equivocal results. Diversity of sample type may provide one explanation for this. The aim of the present study was to examine the latent structure of depression across clinical and community samples using exactly the same taxometric procedures involving exactly the same indicators of depression. Method: Two taxometric procedures, MAXEIG (maximum eigenvalue) and MAMBAC (mean above minus mean below a cut), were carried out on a clinical sample of 960 outpatients with mood and anxiety disorders. Simulated categorical and dimensional data sets as well as other consistency tests aided in the interpretation of the research data. Results were compared to a prior taxometric analysis in a community sample. Results: The results of the current taxometric analyses were consistent with a dimensional latent structure and were compatible with the findings from identical analyses in a community sample. Conclusions: The findings of the current study highlight the importance of identifying factors that may contribute to, and explain, differences in the identified latent structure of depression.
Strong cache consistency in integration systems

Nowadays, a common problem to which many corporations or organizations face is how to easily and uniformly access over multiple, disparate information sources which includes database, object store, knowledge bases, file system, digital libraries, information retrieval system, and electronic mail system. The goal of a data integration system is to provide a uniform query to a multitude of data sources. The key advantage of a data integration system is that it frees users from having to locate the source relevant to their query, interact with each source independently, and manually combine the local answer from the different source to a global answer results. Although a lot of research in integration systems has been proposed over pass ten years, few work was concentrate on the cache consistency problem in such systems. In this paper, we first survey existing caching approach and later explore s strong cache consistency which is suitable to integration systems.
Effects of thermo-resistant non-starch polysaccharide degrading multi-enzyme on growth performance, meat quality, relative weights of body organs and blood profile in broiler chickens.

This research was conducted to study the performance and carcass parameters of broiler chickens fed diets supplemented with heat-treated non-starch polysaccharide degrading enzyme. A total of 432 one-day old Ross 308 broiler chickens were allocated to five treatments: (i) CON (basal diet), (ii) E1: CON + 0.05% multi-enzyme, (iii) E2: CON + 0.1% multi-enzyme, (iv) E3: CON + 0.05% thermo-resistant multi-enzyme and (v) E4: CON + 0.1% thermo-resistant multi-enzyme, each treatment consisted of six replications and 12 chickens in each replication. The chickens were housed in three floor battery cages during 28-day experimental period. On days 1-7, gain in body weight (BWG) improved by feeding the diets supplemented with thermo-resistant multi-enzyme. On days 7-21 and 1-28, chickens fed the diets containing thermo-resistant multi-enzyme showed improved (p < 0.05) BWG and feed conversion ratio (FCR) compared to CON group. Supplementing the diets with multi-enzyme or thermo-resistant multi-enzyme affected the percentage of drip loss on d 1 (p < 0.05). Drip loss percentage on days 3 and 5 and also meat colour were not affected significantly. Supplementing the diets with multi-enzyme or thermo-resistant multi-enzyme did not affect the relative weights of organs but compared to CON group, relative weight of breast muscle increased and abdominal fat decreased (p < 0.05). Among measured blood constituents, chickens fed supplemented diets with thermo-resistant multi-enzyme showed higher (p < 0.05) IgG. Counts of red and white blood cells and lymphocyte percentage were not affected. In conclusion, the results demonstrated that supplementing pelleted diets with thermo-resistant multi-enzyme improved performance of broiler chickens.
Blue-Enhanced PIN Finger Photodiodes in a 0.35-$\mu{\hbox {m}}$ SiGe BiCMOS Technology

Finger photodiodes in PIN technology are introduced to enhance the responsivity for blue and ultraviolet light. A thick low doped epitaxial layer results in high responsivity and high bandwidth also for red and near-infrared light. Results of PIN finger photodiodes are compared to that of PIN photodiodes for 10- and 15-mum epitaxial intrinsic layer thickness. The cathode finger structure results in a high responsivity of 0.20 A/W (quantum efficiency 61%) for 410-nm light and a bandwidth of 1.25 GHz for 10- mum epi thickness at a reverse bias voltage of 3 V. The rise and fall times with an epitaxial layer thickness of 15 mum are below 1 ns for the wavelength range from 410 to 785 nm.
DEVELOPMENT OF A MULTIPLEX PCR TECHNIQUE FOR SIMULTANEOUS DETECTION OF SWEET POTATO FEATHERY MOTTLE VIRUS AND SWEET POTATO CHLOROTIC STUNT VIRUS

Virus diseases, especially those caused by mixed infections, are among the economically most devastating diseases of sweet potato. Sweet potato virus disease (SPVD), which is caused by mixed infection of Sweet potato feathery mottle (SPFMV) and Sweet potato chlorotic stunt virus (SPCSV), is the most widespread in East Africa. Lack of rapid and sensitive techniques for detecting the two viruses makes their control almost impossible. In this study, a multiplex polymerase chain reaction (mPCR) protocol was developed and subsequently evaluated for its effectiveness in simultaneous detection of SPFMV and SPCSV using 13 samples. Total RNA extracts were subjected to reverse transcription followed by PCR with two sets of virus-specific primers. DNA bands of 703 and 235 bp were obtained for SPFMV and SPCSV, respectively. No amplification products were obtained from healthy controls. Results obtained from nitrocellulose membrane enzyme-linked immunosorbent assay (NCM-ELISA) confirmed the efficiency of the mPCR protocol. We recommend the developed mPCR technique for routine molecular diagnostic purposes.
Anterior Exposure of the Lumbar Spine With and Without an “Access Surgeon”: Morbidity Analysis of 265 Consecutive Cases

Study Design Retrospective review Objective To compare the incidence and type of exposure-related complications for anterior lumbar surgery performed with and without an “access” surgeon. Summary of Background Data No data exist comparing the incidence and type of exposure-related complications for anterior lumbar surgery performed with and without a vascular surgeon's assistance. Methods A retrospective review was performed for 265 consecutive patients who underwent anterior lumbar spine surgery at our institution from 2003 to 2005. Each patient's records were reviewed for diagnosis, procedure, whether the surgical exposure was conducted by the spine surgeon (Spine) or with a vascular surgeon's assistance (Team), levels exposed, complications, and any lasting sequelae. Results The percentage of patients with at least 1 intraoperative complication was 8% and 12% for the Spine and Team cases, respectively. Two percent of the Spine patients experienced an intraoperative vascular complication compared with 7% of the Team cases. No intraoperative vascular complication occurred in the single-level Spine exposures. Four percent of the patients with single-level exposures with Team approaches sustained an intraoperative vascular complication. Eight percent of the multilevel Spine cases sustained an intraoperative vascular complication compared with 9% of the multilevel Team exposures. There were 14 vascular injuries appreciated intraoperatively in a total of 13 patients. These injuries were directly repaired in 10 patients without any residual sequelae. The rate of vascular complications was statistically higher for multiple-level exposures (9%) versus single-level exposure (3%; P=0.0357). The rate of retrograde ejaculation was 6% in the Spine cases whereas it was 7% in the Team approach. Conclusions Our results do not support the notion that the presence of an “access” surgeon will change the type and rate of complications. With adequate training and judgment, spine surgeons may safely perform such exposures, provided vascular surgical assistance is readily available.
The Effect of Anonymity on Conformity to Group Norms in Online Contexts: A Meta-Analysis

This research meta-analyzed 13 journal articles regarding anonymity and conformity to group norms. Results showed that there was a positive relationship between anonymity and conformity, with a weighted mean effect size = 0.16, which was in line with the social identity model of deindividuation effects. This study also investigated the differences between different types of anonymity and found that visual anonymity had a medium magnitude of effect size on conformity ( = 0.33), whereas evidence was lacking in terms of the significant effects of physical anonymity and personal information anonymity. In addition, the presence of an outgroup was also a moderator of the effect of anonymity on conformity. Studies in which participants were aware of the existence of an outgroup ( = 0.22) had larger effect sizes than those with no outgroup ( = 0.10).
Evaluation of Chemical Composition for Spirulina platensis in Different Culture Media.

Spirulina platensis was cultivated in laboratory under controlled conditions in four different culture media, BG-11, modified BG-11, Zarrouks (ZM) and synthetic human urine (SHU). The effect of culturing media on chemical composition, amino acids content, fatty acids profile and minerals content were determined. The highest amount of protein (59.8%) was recorded when grown in BG-11. Whereas, modified BG-11 was the best medium in regard to both amino acids contents and maximum total lipid (8.13%). The most important unsaturated fatty acid γ-linolenic, was found at maximum percentage (4.7%) when grown in SHU medium. Whereas ZM was the best medium to obtain the highest percentage of arachidoic acid (17.63%). The highest percentage of ash in S. platensis was recorded when grown in ZM. Regarding to the minerals content, the maximumP, Ca, Mg, Zn and Cu (182.7, 155.8, 8.4, 5.1 and 5.5 mg/100g DW, respectively) were recorded in BG- 11, while growing in ZM displayed the highest amount of K, Na and Fe (593.4, 766.7 and 39.9 mg/100g, respectively).
Stimulation and inhibition of growth by EGF in different A431 cell clones is accompanied by the rapid induction of c‐fos and c‐myc proto‐oncogenes.

Stimulation of quiescent fibroblasts to growth by polypeptide growth factors is accompanied by the rapid induction of c‐fos and c‐myc proto‐oncogenes. In contrast to fibroblasts, A431 cells respond to epidermal growth factor (EGF) with a decreased growth rate. Here we report that, in spite of its growth inhibitory effect, EGF rapidly induces transient expression of c‐fos mRNA, followed by the synthesis of nuclear c‐fos protein. In addition, EGF treatment resulted in elevated levels of c‐myc expression. Practically identical results were obtained with variant A431 clones that are resistant to the inhibitory effect of EGF on cell proliferation. These observations suggest that in A431 cells c‐fos and c‐myc induction is a primary consequence of growth factor‐receptor interaction. Indeed, efficient induction of both genes was also observed with cyanide bromide‐cleaved EGF, which has previously been shown to be non‐mitogenic but able to trigger early events induced by EGF. We observed strong induction of c‐fos and to a lesser extent of c‐myc also by TPA, and by the calcium ionophore A23187, indicating an important role for kinase C in proto‐oncogene activation by growth factors.
Use of Harmonic shear vs Titanium clips in Laparoscopic Cholecystectomy : Experience in Nawaz Sharif Social Security Teaching Hospital Lahore

Background: Laparoscopic cholecystectomy (LC) is the procedure of choice for symptomatic gall stones. Conventionally titanium clips are used to close cystic duct (CD) & Cystic artery (CA) followed by division with endoscopic scissors and Gall bladder (GB) dissection with electro cautery using Lhook. To reduce complications and for ease of use, alternative techniques including use of harmonic shears to close & divide CD & CA and GB dissection have been introduced although not widely practiced as yet. Aim: To compare the duration of operation, safety and complications ofconventional method versus Harmonic shear method for closure and division of cystic duct (CD) and cystic artery (CA) and GB dissection during laparoscopic cholecystectomy. Methods: 86 patients with symptomatic gall stones listed for Laparoscopic cholecystectomy were included in the study and randomised in two groups. 43 patients in one group were planned to undergo closure of CD & CA with titanium clips and division with endoscopic scissors followed by dissection of gall bladder with electro cautery using L-hook (TC group). 43 patients in second group were planned to have closure and division of CD & CA and dissection of GB using harmonic shears (HS group). Duration of operation, perop & postope bleeding and biliary leakage were compared between2 groups. Results:There was no significant difference in the rate of complications of bleeding & bile leakbetween the two groups. However the duration of operation was significantly shorter in HS group. Conclusion: Use of harmonic shears in Laparoscopic cholecystectomy to close and divide CD & CA and GB dissection is safe with the added advantage of ease of use and time saving compared to conventional titanium clip closure of CD & CA, division with endoscopic scissors and GB dissection with diathermy using L-hook.
A Direct Aspiration, First Pass Technique (ADAPT) versus Stent Retrievers for Acute Stroke Therapy: An Observational Comparative Study

BACKGROUND AND PURPOSE: Mechanical thrombectomy with stent retrievers is now the standard therapy for selected patients with ischemic stroke. The technique of A Direct Aspiration, First Pass Technique for the Endovascular Treatment of Stroke (ADAPT) appears promising with a high rate of recanalization. We compared ADAPT versus stent retrievers (the Solitaire device) for efficacy and safety as a front-line endovascular procedure. MATERIALS AND METHODS: We analyzed 243 consecutive patients with large intracranial artery occlusions of the anterior circulation, treated within 6 hours with mechanical thrombectomy by either ADAPT or the Solitaire stent. Th primary outcome was complete recanalization (modified TICI ≥ 2b); secondary outcomes included complication rates and procedural and clinical outcomes. RESULTS: From November 2012 to June 2014, 119 patients were treated with stent retriever (Solitaire FR) and 124 by using the ADAPT with Penumbra reperfusion catheters. The median baseline NIHSS score was the same for both groups (Solitaire, 17 [interquartile range, 11–21] versus ADAPT, 17 [interquartile range, 12–21]). Time from groin puncture to recanalization (Solitaire, 50 minutes [range, 25–80 minutes] versus ADAPT, 45 minutes [range, 27–70 minutes], P = .42) did not differ significantly. However, compared with the Solitaire group, patients treated with ADAPT achieved higher final recanalization rates (82.3% versus 68.9%; adjusted relative risk, 1.18; 95% CI, 1.02–1.37; P = .022), though differences in clinical outcomes between the cohorts were not significant. Use of an adjunctive device was more frequent in the ADAPT group (45.2% versus 13.5%, P < .0001). The rate of embolization in new territories or symptomatic hemorrhage did not differ significantly between the 2 groups. CONCLUSIONS: Front-line ADAPT achieved higher recanalization rates than the Solitaire device. Further randomized controlled trials are warranted to define the best strategy for mechanical thrombectomy.
Strong fiber Bragg grating fabrication by hybrid 157- and 248-nm laser exposure

A permanent 248-nm photosensitivity response was locked into hydrogen-loaded standard telecommunication fiber by uniform 157-nm F/sub 2/-laser pre-exposure. Strong (>30 dB) fiber Bragg gratings were efficiently generated after hydrogen out-diffusion, improving the thermal stability. The 157-mn radiation produced weakly absorbing Si-OH and Ge-OH absorption bands at 1.39-/spl mu/m.
Restoring a Sense of Control During Implementation: How User Involvement Leads to System Acceptance

User involvement has long been considered a critical component of effective system implementation. However, the perspective has suffered from mixed results of empirical tests and the lack of a theoretical explanation for the relationship (Ives and Olson, 1984; Baroudi, et al., 1986). Our purpose is to present a theoreticallygrounded perspective to account for effects of involving users during implementation, and to provide an initial test of this perspective. We propose that: (1) system implementation represents a threat to users’ perceptions of control over their work and a period of transition during which users must cope with differences between old and new work systems; (2) user involvement is effective because it restores or enhances perceived control. Results of a field experiment designed as a preliminary test of this perspective are discussed.