Miracle-dz/UniFAR-FTUs huggingface dataset:
Ocular injuries--in union territory of Pondicherry--visual outcome.

The visual outcome in 309 cases of ocular trauma hospitalised over a 7 year period has been studied. There was total visual loss in 63 patients (20.3%) and poor vision in 108 (34.60%), moder­ate visual impairment was seen in 35 (13.92%) and good vision retained in 83 (26.89%). In a small number of patients visual assessment was not possible (3.88%).
Constraining Wind Stress Products with Sea Surface Height Observations and Implications for Pacific Ocean Sea Level Trend Attribution

A number of global surface wind datasets are available that are commonly used to examine climate variability or trends and as boundary conditions for ocean circulation models. However, discrepancies exist among these products. This study uses observed Archiving, Validation, and Interpretation of Satellite Oceanographic (AVISO) sea surface height anomalies (SSHAs) as a means to help constrain the fidelity of these products in the tropical region. Each wind stress product is used to force a linear shallow water model (SWM) and the resulting hindcast thermocline depth anomalies are converted to SSHAs. The resulting SSHAs are then assessed to see how well they reproduce the dominant EOF modes of observed variability and the regional (global mean removed) sea level trend (1993‐2007) in each of the three ocean basins. While the results suggest that all wind datasets reproduce the observed interannual variability with reasonable fidelity, the two SWM hindcasts that produce the observed linear trend with the highest fidelity are those incorporatinginterimECMWFRe-Analysis(ERA-Interim)andWave-andAnemometer-BasedSeaSurface Wind (WASWind) forcing. The role of surface wind forcing (i.e., upper ocean heat content redistribution) versus global mean sea level change (i.e., including the additional contributions of glacier and ice sheet melt along with ocean thermal expansion) on the recent dramatic increase in western equatorial Pacific island sea level is then reassessed. The results suggest that the recent sea level increase cannot be explained solely by wind stress forcing, regardless of the dataset used; rather, the global mean sea level signal is required to fully explain this observed recent abrupt sea level rise and to better explain the sea level variability of the last 50‐60 years.
Do the parent-child relationship and parenting behaviors differ between families with a child with and without chronic illness? A meta-analysis.

OBJECTIVE The present meta-analysis compared the quality of the parent-child relationship as well as parenting behaviors and styles of families with a child with chronic physical illness with families of healthy children or test norms. METHODS Empirical studies were identified with the help of electronic databases and cross-referencing. Based on 325 included studies, random-effects meta-analysis was performed. RESULTS Although most effect sizes were small or very small, the parent-child relationship tended to be less positive if a child had a chronic physical illness (g = -.16 standard deviation units). In addition, lower levels of parental responsiveness (emotional warmth; g = -.22) as well as higher levels of demandingness (control, monitoring; g = .18) and overprotection (g = .39) were observed in these families. However, effect sizes were heterogeneous and only significant for a limited number of diseases. There was also some evidence for higher levels of authoritarian (g = .24) and neglectful parenting (g = .51) as well as lower levels of authoritative parenting compared with families with healthy children (g = -.13). Effect sizes varied, in part, by length of illness, child age, rater, assessment method, and target of comparison. CONCLUSIONS We conclude that most families with a child with chronic physical illness adapt well with regard to the parent-child relationship and parenting behaviors/styles. Nonetheless, some families of children with specific diseases-such as epilepsy, hearing impairment, and asthma-may have difficulties finding appropriate levels of protective behaviors, control, and parental warmth and building positive mutual relationships between parents and children.
The impact of geographic proximity between auditor and client on audit quality: empirical evidence from Australia

9 Chapter One Introduction . 10 1.1 Background of the Study . 10 1.2 Motivation and Objectives. 14 1.3 Main discussion of the study . 16 1.4 Significance of the Study . 17 1.5 Limitation of the Study . 18 1.6 Disposition of the Thesis . 20 Literature Review . 22 2.1 Overview of the chapter . 22 2.2 Audit quality. 22 2.3 Geographic Proximity . 26 2.3.1 Geographic proximity and advantages . 28 2.3.2 Geographic proximity and financial reporting . 31 2.3.3 Geographic proximity and economic agent . 32 2.3.4 Geographic Proximity and auditor’s independence . 34 2.4 Geographic Proximity and Audit quality . 36 2.5 Auditor-client relationship . 39 2.6 Audit quality, auditor-client relationship and geographic proximity (auditor locality) . 40 2.7 Summary of the Chapter . 42 Theoretical perspective and hypotheses development . 43 3.1 Overview of the Chapter . 43 3.2 Theoretical perspective (Audit quality) . 43 3.2.1 Information asymmetry theory and audit quality. 44 3.2.2 Agency theory and audit quality . 45 3.3 Theory Selection . 46 3.4 Developing hypotheses (Geographic proximity and its impact of audit quality) 47 H1: Audits performed by local auditors are of higher quality than audits performed by non-local auditors, other things being equal . 48 3.5 Summary of the Chapter . 49 Sample Selection, Data and Time Period . 51 4.1 Overview of the Chapter . 51
The Entrepreneurial Behavior and Practical Industrial Work Experience as the Determinant Factor of Entrepreneurial Intention

Generally speaking, competent workers and entrepreneur ready graduate are the challenges in the education system, especially for Vocational High School. This paper aimed to reveal the entrepreneurial behavior and industrial work practice experience as the determinant factor of entrepreneurial intentions of Vocational High School 2 in Singkawang City. This research employed descriptive method in the form of correlation research study with 44 graduate students as sample of this research. Results revealed that in fact, (1) the entrepreneurial behavior factor is significantly and positively influences the entrepreneurial intention, (2) the factor of industrial work practice experience is significantly and positively influences the entrepreneurial intention, and (3) the entrepreneurial behavior and the experience of industrial work practice are both significantly and positively influence the entrepreneurial intention. Considering the foregoing results, it is demanding for Vocational High School to improve their quality in to create professional competency for
Fuzzy control of a class of uncertain networked control systems with multiple time-delays

This paper deals with the controller design problem of a networked control system with multiple time-delays and the presence of network-induced delay. The Takagi-Sugeno (T-S) fuzzy model is adopted for representing networked control systems. Based on a novel Lyapunov-Krasovskii functional and LMI technique, some sufficient conditions for the NCS which is subject to the asymptotic stability are derived, and the method of the controller design is also given in terms of LMIs. Finally, an example shows the effectiveness of the proposed method.
Prognostic significance of DNA flow cytometric analysis in patients with nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC) is a prevalent malignant tumor among Southern Chinese. Previously, the authors described the prognostic significance of a serum antibody assay to a recombinant Epstein‐Barr virus Bam HI‐Z replication activator protein (ZEBRA) in NPC patients with long term follow‐up. In this study, the authors further reported the use of DNA flow cytometry (DNA‐FCM) as an additional technique for determining the prognosis of NPC patients in the same series.
Interexaminer reliability in physical examination of the neck.

BACKGROUND There are numerous clinical tests used in the evaluation of patients with symptoms arising from the cervical spine. It is necessary to use clinical tests with high validity and reliability. Previous studies of reliability of clinical tests used in the evaluation of the cervical spine have come to various conclusions, most of which suggest low reliability. This might be explained by differences between examiners in performance and where the limit of normality is placed. OBJECTIVE To evaluate the interexaminer reliability of clinical tests used in everyday clinical work, where the examiners base their evaluations on a comparison between left and right sides. STUDY DESIGN A total of 50 volunteers were examined by two physiotherapists. The interexaminer reliability of clinical tests included in the physical examination of patients with symptoms from the cervical spine was evaluated. METHODS Two physiotherapists independently examined volunteers. RESULTS An acceptable reliability was found for two of 10 clinical tests. CONCLUSION When it is possible to compare left and right sides, it is possible to show acceptable reliability for some clinical tests. Reliability studies most often find low reliability, perhaps because of bias; clinical tests are not standardized. In future studies, greater efforts should be taken to reduce bias.
Cor Pulmonale: An Overview

Chronic cor pulmonale involves the enlargement of the right ventricle as a result of pulmonary hypertension due to pulmonary disorders involving the lung parenchyma, bellows function, or ventilatory drive. The right ventricular hypertrophy that occurs in chronic cor pulmonale is a direct result of chronic hypoxic pulmonary vasoconstriction and subsequent pulmonary artery hypertension, leading to increased right ventricular work and stress. We discuss methods by which hypoxic vasoconstriction and reduction in the pulmonary vascular bed lead to the development of pulmonary artery hypertension. This article reviews the interaction of the pulmonary vasculature and right ventricle in the non-diseased state as well as during disease exacerbations. Ventricular dependence and its contribution to the pathophysiology of right ventricular failure are also reviewed. In addition, we provide an overview of specific disease states that can result in the development of chronic cor pulmonale including chronic obstructive pulmonary disease (COPD), interstitial lung disease, sleep apnea, alveolar hypoventilation disorders, and primary pulmonary hypertension. We also review the current diagnostic studies used to evaluate and study cor pulmonale.
Identification of Genetic Bases of Vibrio fluvialis Species-Specific Biochemical Pathways and Potential Virulence Factors by Comparative Genomic Analysis

ABSTRACT Vibrio fluvialis is an important food-borne pathogen that causes diarrheal illness and sometimes extraintestinal infections in humans. In this study, we sequenced the genome of a clinical V. fluvialis strain and determined its phylogenetic relationships with other Vibrio species by comparative genomic analysis. We found that the closest relationship was between V. fluvialis and V. furnissii, followed by those with V. cholerae and V. mimicus. Moreover, based on genome comparisons and gene complementation experiments, we revealed genetic mechanisms of the biochemical tests that differentiate V. fluvialis from closely related species. Importantly, we identified a variety of genes encoding potential virulence factors, including multiple hemolysins, transcriptional regulators, and environmental survival and adaptation apparatuses, and the type VI secretion system, which is indicative of complex regulatory pathways modulating pathogenesis in this organism. The availability of V. fluvialis genome sequences may promote our understanding of pathogenic mechanisms for this emerging pathogen.
Novel triblock co‐polymer nanofibre system as an alternative support for embryonic stem cells growth and pluripotency

Conventionally, embryonic stem cells (ESCs) are cultured on gelatin or over a mitotically inactivated monolayer of mouse embryonic fibroblasts (MEFsi). Considering the lack of versatile, non‐animal‐derived and inexpensive materials for that purpose, we aimed to find a biomaterial able to support ESC growth in a pluripotent state that avoids the need for laborious and time‐consuming MEFsi culture in parallel with mouse ESC (mESC) culture. Undifferentiated mESCs were cultured in a new nanofibre material designed for ESC culture, which is based on the self‐assembly of a triblock co‐polymer, poly(ethyleneglycol‐β‐trimethylsilyl methacrylate‐β‐methacrylic acid), conjugated with the peptide glycine–arginine–glycine–aspartate–serine, to evaluate its potential application in ESC research. The morphology, proliferation, viability, pluripotency and differentiation potential of mESCs were assessed. Compared to conventional stem cell culture methodologies, the nanofibres promoted a higher increase in mESCs number, enhanced pluripotency and were able to support differentiation after long‐term culture. This newly developed synthetic system allows the elimination of animal‐derived matrices and provides an economic method of ESC culture, made of a complex network of nanofibres in a scale similar to native extracellular matrices, where the functional properties of the cells can be observed and manipulated. Copyright © 2013 John Wiley & Sons, Ltd.
The Role of the Orthopaedic Surgeon in Minimizing Mortality and Morbidity Associated With Fragility Fractures

&NA; Osteoporosis is an underrecognized and undertreated condition associated with fracture. More than 2 million fragility fractures occur each year, almost 300,000 of them hip fractures associated with a threefold risk for future fractures, as well as a 15% to 33% mortality rate within the first year of fracture. Orthopaedic surgeons can facilitate osteoporosis treatment by coordinating care for patients with fragility fractures by managing the current fracture, evaluating risk factors for osteoporosis, and, for hospitalized patients, developing a follow‐up plan that notes whether the patient should be further evaluated or treated for osteoporosis. For the patient seen in the office, evaluation for osteoporosis should be performed and, if indicated, treatment should be undertaken. When osteoporosis treatment is warranted, diphosphonates are the standard of care, and administration of zoledronic acid once yearly has been proven to reduce the risk of subsequent fractures after low‐energy hip fracture. By following these steps, orthopaedic surgeons can help ensure that patients with fragility fractures receive appropriate osteoporotic treatment, thereby reducing the risk of subsequent fractures.
Viabilidade técnica e econômica da irrigação localizada do cafeeiro, nas condições climáticas do planalto de Araxá, MG

: In the region of Araxa highlands, the economical production of coffee is traditionally made without irrigation. Notwithstanding in recent years, with climate change, water deficit of 150 mm have been verified, affecting the vegetative and productive development of the culture. Within this context, the aim of this study was to evaluate supplementary irrigation to increase production and profitability of the coffee grown in the highlands of Araxa, compared to a non-irrigated and irrigated cultivation throughout the year. The work was implemented in Araxa, Minas Gerais in 2006 and carried out throughout the period of nine years. Different periods of water stress (from April to November) were evaluated, compared with irrigation throughout the year and the witness. After 6 consecutive harvests, it can be concluded that supplemental irrigation promoted an increased productivity in the coffee grown under the conditions of the Araxa Plateau, especially in years of drought. With regard to economic performance, the process of irrigation applied throughout the year promoted profits of 279% (R$/ha year-1) compared to the treatment without irrigation.
Verapamil, a Calcium-Channel Blocker, Improves the Wound Healing Process in Rats with Excisional Full-Thickness Skin Wounds Based on Stereological Parameters

OBJECTIVE:Calcium can play noticeable roles in the wound-healing process, such as its effects on organization of F-actinin collagen bundles by fibroblasts at the injury site. In addition, calcium-channel blockers such as verapamil have antioxidant activity by increasing nitric oxide production that promotes angiogenesis, proliferation of fibroblasts, and endothelial cells in the skin-regeneration process. Therefore, in this study, the authors’ objective was to investigate the effects of verapamil on the process of wound healing in rat models according to stereological parameters. MATERIALS AND METHODS:In this experimental study, 36 male Wistar rats were randomly divided into 3 groups (n = 12): the control group that received no treatment, gel-base–treated group, and the 5% verapamil gel–treated group. Treatments were done every 24 hours for 15 days. Wound closure rate, volume densities of the collagen bundles and the vessels, vessel’s length density and mean diameter, and fibroblast populations were estimated using stereological methods and were analyzed by the Kruskal-Wallis and Mann-Whitney U tests; P < . 05 was considered statistically significant. RESULTS:The verapamil-treated group showed a faster wound closure rate in comparison with control and gel-base groups (P = .007 and P = .011). The numerical density of fibroblasts, volume density of collagen bundles, mean diameter, and volume densities of the vessels in the verapamil group were significantly higher than those in the control and the base groups (P < .005). CONCLUSIONS:The authors showed that verapamil has the ability to improve wound healing by enhancing fibroblast proliferation, collagen bundle synthesis, and revascularization in skin injuries.
Relationship Between Fasting Plasma Insulin Level and Resistance to Insulin-Mediated Glucose Uptake in Normal and Diabetic Subjects

We have previously shown that a significant inverse correlation exists between the height of the plasma insulin concentration and the efficiency of glucose uptake in the fasting state. Subsequently, we devised an infusion technic that provides a more specific measure of cellular resistance to insulin mediated glucose uptake. We have used this technic to study the relationship between fasting plasma insulin level and resistance to insulin mediated glucose uptake in twenty-two patients with normal oral glucose tolerance, fourteen patients with impaired glucose tolerance, and fourteen patients classified as having chemical diabetes mellitus. The results indicate a highly significant positive correlation between the degree of insulin resistance and fasting plasma insulin concentration (r = .69, p < .0001). A positive correlation (r = .43, p < .005) was also found between the degree of insulin resistance and the two hour plasma glucose level during an oral glucose tolerance test. However, no significant correlation was found between per cent adiposity and fasting insulin level, and the relationship between insulin resistance and fasting insulin level appeared to be independent of obesity or any other known cause of decreased insulin responsiveness. These studies indicate that: (1) increases in fasting insulin levels and increase in resistance to insulin mediated glucose uptake are closely related, and that these changes can occur in the absence of any of the “known” causes of decreased insulin responsiveness; (2) in the types of subjects we have studied, deterioration of glucose tolerance is closely related to increases in insulin resistance; and (3) the increases in fasting insulin levels which we have observed appear to be compensatory attempts to overcome the resistance to glucose uptake.
The auditory transient 40‐Hz response is insensitive to changes in stimulus features

TEN subjects were presented with tone pips occasionally interspersed with deviant tone pips of a higher frequency. The transient 40-Hz response was insensitive to change in qualitative stimulus features. In contrast, stimulus changes elicited a later, and slower event-related potential, the mismatch negativity (MMN). As a response to changes in stimulus features implies the existence of a memory system, and because changes in qualitative stimulus aspects do not activate the generator mechanisms underlying the 40-Hz response, the 40-Hz response can be dissociated from memory mechanisms. Furthermore, the analysis of phase-locked (synchronous), and non-phase-locked (asynchronous) responses revealed that the 40-Hz response might be caused by the synchronization of already active oscillators.
Exploring the Motivational and Behavioral Foundations of External Technology Experts’ Knowledge Sharing in Collaborative R&D Projects: The Contingency Role of Project Formalization

High-tech manufacturers increasingly rely on the knowledge contributions of external technology experts (ETEs), who contribute to collaborative R&D projects on behalf of suppliers. Many scholars have considered knowledge sharing in R&D collaborations from a firm-level or project-level perspective and focused on formalization as a potential remedy. While individual supplier employees at the operative level make the decision to share critical knowledge, the individual-level perspective in literature on knowledge sharing in collaborative R&D projects is virtually nonexistent. Because knowledge sharing in collaborative R&D is a largely discretionary act on behalf of the supplier employee, personal motivations rather than inter-firm relationship elements (e.g., network position or dependency) become the primary determinant of one’s sharing behavior. Abstracting from or ignoring these motivations of supplier employees in studies on collaborative R&D may obscure important insights for R&D managers. This study is an important first step in providing the empirical evidence needed to uncover the motivational and behavioral foundations for ETEs’ knowledge sharing in a collaborative R&D setting. Building on theories of gift and social exchange, this article identifies customer stewardship and distributive fairness as two important personal motivations of ETEs to share knowledge. Project formalization is considered as a key contingency condition. Analyzing survey responses of 186 ETEs, a multilevel regression-based moderated-mediation analysis of direct and indirect effects shows that customer stewardship predicts an ETE’s knowledge sharing behavior under (very) low levels of project formalization, and distributive fairness predicts knowledge sharing behavior under medium to high levels of formalization. Together, the results provide R&D project managers who aim to leverage external knowledge contributions with valuable insights that have been obscured in past firm-level collaborative R&D studies.
Synthesis, molecular docking, and antitumoral activity of alnustone-like compounds against estrogen receptor alpha-positive human breast cancer

Alnustone-like compounds are promising inhibitors for estrogen receptor a (ER-a), which is a novel cancer therapeutic target. Therefore, 10 alnustone-like compounds with substituents at the phenyl rings were synthesized by condensation of 4-phenyl-2-butanones and cinnamaldehydes via in situ enamination. The compounds displayed either protective activity or inhibited cell growth and proliferation of human breast cancer cells. Molecular docking studies indicated that the synthesized compounds interact with ER-a efficiently. In this work, the protective and inhibitive roles of the synthesized compounds were related to their functional groups and to their binding mode of action on ER-a protein. The compounds are potential drug candidates as ER-a antagonists.