Miracle-dz/UniFAR-FTUs huggingface dataset:
HLA and microtubule-associated protein tau H1 haplotype associations in anti-IgLON5 disease

Objectives We investigated the associations with HLA and microtubule-associated protein tau (MAPT) H1 haplotype in anti-IgLON5 disease, a recently identified disorder characterized by gait instability, brainstem dysfunction, and a prominent sleep disorder in association with IgLON5 antibodies and pathologic findings of a novel neuronal-specific tauopathy. Methods We compared the HLA alleles and MAPT H1/H1 genotype of 35 patients with anti-IgLON5 with healthy controls. The on-line server tool NetMHCIIpan 3.1 was used to predict the IgLON5 peptide binding to HLA Class II molecules. Results The HLA-DRB1*10:01-DQB1*05:01 haplotype was overrepresented in patients with anti-IgLON5 disease (OR = 54.5; 95% CI: 22.2–133.9, p < 0.0001). In addition, HLA-DQA was genotyped in 27 patients, and 25 (92.6%) of them had DQ molecules composed by DQA1*01 and DQB1*05 chains compared with 148/542 (27.3%) controls (OR = 43.9; 95% CI: 10.4–185.5, p < 0.0001). Patients DRB1*10:01 positive developed more frequently sleep or bulbar symptoms than those carrying other HLA alleles (70.0% vs 26.7%; p = 0.011). Prediction algorithms identified 2 IgLON5 peptides (1 located in the signal sequence) that showed strong binding to HLA-DRB1*10:01 and other HLA-DRB1, but not to HLA-DQA and HLA-DQB molecules. The MAPT H1/H1 homozygous genotype was present in 20/24 (83.3%) anti-IgLON5 Caucasian patients compared with 54/116 (46.5%) healthy controls (p = 0.0007). Conclusions The robust association of anti-IgLON5 disease with distinct HLA Class II molecules supports a primary autoimmune origin. The significant association of MAPT H1 haplotype also suggests that an underlying neurodegenerative process could be involved in anti-IgLON5 disease.
Probing the Surface Structure of Semiconductor Nanoparticles by DNP SENS with Dielectric Support Materials.

Surface characterization is crucial for understanding how the atomic-level structure affects the chemical and photophysical properties of semiconducting nanoparticles (NPs). Solid-state nuclear magnetic resonance spectroscopy (NMR) is potentially a powerful technique for the characterization of the surface of NPs, but it is hindered by poor sensitivity. Dynamic nuclear polarization surface enhanced NMR spectroscopy (DNP SENS) has previously been demonstrated to enhance the sensitivity of surface-selective solid-state NMR experiments by one to two orders of magnitude. Established sample preparations for DNP SENS experiments on NPs require the dilution of the NPs on mesoporous silica. Using hexagonal boron nitride (h-BN) to disperse the NPs doubles DNP enhancements and absolute sensitivity as compared to standard protocols with mesoporous silica. Alternatively, precipitating the NPs as powders, mixing them with h-BN, then impregnating the powdered mixture with radical solution leads to further four-fold sensitivity enhancements by increasing the concentration of NPs in the final sample. This modified procedure provides a factor 9 improvement in NMR sensitivity as compared to previously established DNP SENS procedures, enabling challenging homonuclear and heteronuclear 2D NMR experiments on CdS, Si and Cd3P2 NPs. These experiments allow NMR signals from the surface, sub-surface and core sites to be observed and assigned. For example, we demonstrate that the acquisition of DNP-enhanced 2D 113Cd113Cd correlation NMR experiments on CdS NPs and natural isotropic abundance 2D 13C29Si HETCOR of functionalized Si NPs. These experiments provide a critical understanding of NP surface structures.
Missing Piece in Understanding Student Learning: Out-of-School Computer Use

Advancements in learning analytics allow teachers to track student learning progress and promote learning by providing necessary intervention and support. Multiple data sources are involved in learning analytics, and the major ones are systems that students use in school. To fully comprehend the progress of student learning, out-of-school learning behaviors should be considered an important part of the academic lives of students. In this study, out-of-school learning behaviors of students, particularly home computer use, were measured using four online behavior indicators of students, which were tracked and collected. The learning performance data of the students were analyzed. Results suggested that the out-of-school computer use behaviors of students, such as mutual follow-up and the sharing of learning experiences, were positively related to their academic performance level, regardless of the age and gender of the students. This study provides insight into what may be the missing piece in understanding student learning, that is, out-of-school computer use. With such insights, learning analytics may be enhanced to improve the understanding of learning without being restricted to schools.
Drug therapy problems for patients with tuberculosis and HIV/AIDS at a reference hospital

ABSTRACT Objective: To determine the frequency of drug therapy problem in the treatment of patients with tuberculosis and HIV/AIDS. Methods: Data were obtained through a cross-sectional study conducted between September 2015 and December 2016 at a reference hospital in infectious diseases in Belo Horizonte (MG), Brazil. Sociodemographic, clinical, behavioral and pharmacotherapeutic variables were evaluated through a semi-structured questionnaire. Drug-related problems of pharmaceutical care were classified using the Pharmacotherapy Workup method. Factors associated with indication, effectiveness, safety and compliance drug therapy problem were assessed through multiple logistic regression. Results: We evaluated 81 patients, and 80% presented at least one drug therapy problem, with indication and adherence drug therapy problem being the most frequent. The factors associated with drug therapy problem were age, marital status, new case, ethnicity, time of HIV diagnosis and time to treat tuberculosis. Conclusion: The frequency of drug therapy problem in coinfected patients was high and the identification of the main drug therapy problem and associated factors may lead the multiprofessional health team to ensure the use of the most indicated, effective, safe and convenient medicines for the patients clinical condition. Tuberculosis and HIV/AIDS coinfected individuals aged over 40 years are more likely to have drug therapy problems during treatment; in that, the most frequente are those that signal toward need of medication for an untreated health condition and non-compliance to treatment. Thus, older patients, unmarried or married, who have treated tuberculosis before, with a shorter time to tuberculosis treatment and longer time to diagnose HIV/AIDS, should receive special attention and be better followed by a multiprofessional health team because they indicate a higher chance of presenting Problems related to the use of non-adherent drugs.
The development and psychometric evaluation of the Chinese Big Five Personality Inventory-15

The Chinese Big Five Personality Inventory (CBF-PI), a 134-item self-report scale, and its 40-item brief version (CBF-PI-B) are sound psychometric instruments used to measure the Big Five personality domains in the Chinese population. However, their applicability is limited by their length, as well as restricted by assessment conditions. In this study, we developed and validated a new shortened version with 15 items (CBF-PI-15) through exploratory factor analysis and confirmatory factor analysis in a large sample (Sample 1) of 10,738 Chinese adults (mean = 33.90 years, SD = 9.39 years, range 17–57 years). Measurement invariance results suggested the CBF-PI-15 were invariant across gender and age groups. Convergent, discriminant and criterion validities were tested in Sample 2 (N = 256, mean = 21.62 years, SD = 3.06 years, range 18–35 years) and findings showed an expected correlational pattern with external variables. Results revealed positive correlations of Neuroticism with the Barratt Impulsiveness Scale Brief Version (BIS-Brief), the Patient Health Questionnaire, and the Generalized Anxiety Disorder Screener, as well as a strongly negative correlation between Conscientiousness and BIS-Brief. Additionally, Conscientiousness positively correlated with academic performance as expected. In conclusion, the CBF-PI-15 holds promise as an informative alternative for the original CBF-PI-B when administration time or conditions are limited, and our findings provide preliminary support for the utility of the CBF-PI-15.
High-Value Care Culture Among the Future Physician Workforce in Internal Medicine.

PURPOSE Training in high-spending regions correlates with higher spending patterns among practicing physicians. This study aimed to evaluate if trainees' exposure to a high-value care culture differed based on type of health system in which they trained. METHOD In 2016, 517 internal medicine residents at 12 California graduate medical education (GME) programs (university, community, and safety-net medical centers) completed a cross-sectional survey assessing perceptions of high-value care culture within their respective training program. The authors used multilevel linear regression to assess the relationship between type of medical center and High-Value Care Culture Survey (HVCCS) scores. The correlation between mean institutional HVCCS and Centers for Medicare and Medicaid Services' Value-Based Purchasing (VBP) scores was calculated using Spearman rank coefficients. RESULTS Of 517 residents, 306 (59.2%), 83 (16.1%), and 128 (24.8%) trained in university, community, and safety-net GME programs, respectively. Across all sites, the mean HVCCS score was 51.2 (SD 11.8) on a 0-100 scale. Residents reported lower mean HVCCS scores if they were from safety-net based training programs (β -4.4, 95% confidence interval -8.2, -0.6) with lower performance in the leadership and health system messaging domain (P < .001). Mean institutional HVCCS scores among university and community sites positively correlated with institutional VBP scores (Spearman r = 0.71, P < .05). CONCLUSIONS Safety-net trainees reported less exposure to aspects of high-value care culture within their training environments. Tactics to improve the training environment to foster high-value care culture include training, increasing access to data, and improving open communication about value.Written work prepared by employees of the Federal Government as part of their official duties is, under the U.S. Copyright Act, a "work of the United States Government" for which copyright protection under Title 17 of the United States Code is not available. As such, copyright does not extend to the contributions of employees of the Federal Government.
Variability of Surface Layer CO 2 Parameters in the Western and Central Equatorial Pacific

We present the results of the oceanic and the atmospheric CO2 measurements in the warm pool and in the divergence zone of the western and central equatorial Pacific (135°E to 160°W), made during 18 cruises from January 1994 to January 2003. The majority of these measurements were made in boreal winter (December to February), the parameters measured including partial pressure of CO2 in near-surface seawater (pCO2sw) and in the atmosphere (pCO2air), total inorganic carbon (TCO2), and total hydrogen ion concentration (pH). Total alkalinity (TA) was calculated from these parameters using other oceanographic parameters. In the warm pool in the western equatorial Pacific where salinity is relatively low (S < 35), a moderate CO2 supersaturation (0 < ∆pCO2/μatm < +30: ∆pCO2 = pCO2sw – pCO2air) due to high temperature (28.5 < T/°C < 31) and low salinity-normalized TCO2 (NTCO2: ca. 1940 μmol kg–1 at S = 35) was typically observed. In this region, the variability of pCO2sw is controlled mainly by the variation of temperature and salinity. However, when the barrier layer has developed, pCO2sw decreased to turn to a slight CO2 subsaturation (–10 < ∆pCO2/μatm < 0) with the decrease of NTCO2 (<1930 μmol kg–1) due to net biological uptake. In the equatorial divergence zone where salinity is relatively high (S > 35), near-surface water is highly supersaturated with CO2 (+30 < ∆pCO2/μatm < +120) as a results of the higher NTCO2 (1960 < NTCO2/ μmol kg–1 < 2030) and low salinity-normalized TA (NTA: ca. 2320 μmol kg–1 at S = 35). The westward decrease of high pCO2sw in this zone is ascribed to the westward decrease of NTCO2 and a small variation in NTA, but ca. 60% of these effects are compensated by the westward elevation of temperature. The abrupt change in pCO2sw at the boundary zone between the warm pool and the divergence zone is explained largely by the change in NTCO2 and partly by the change in salinity. Empirical relationships between NTCO2 and temperature and between NTA and temperature in near-surface water were derived both for the warm pool and for the divergence zone based on a total of 5069 data from underway measurements and 184 from discrete samples taken after 1990. Combining these relationships and a data set of temperature, fields of NTCO2, NTA, and *Present address: Graduate School of Environmental Earth Science, Hokkaido University, N10W5, Kita, Sapporo 060-0810, Japan. Global Environmental Change in the Ocean and on Land, Eds., M. Shiyomi et al., pp. 59–94. © by TERRAPUB, 2004.
Determinants of e-Government Adoption in Improving Public Services Delivery in Immigration Department Arusha Region, Tanzania

The paper assesses the determinants of the e-Government in improving public service delivery in Arusha Regional Immigration Office, Tanzania. It is a descriptive research designed to adopt the survey method using the questionnaire and interviews. A sample 60 respondents was used. The data was analysed using the descriptive and inferential methods. The study finds that infrastructure especially Information Technology influences the way e-Government has improved the public services delivery in Immigration Department in Tanzania. This suggests that the efficiency and effectiveness of the public service delivery are significantly related to e-Government. The study recommends that there is need to improve on e-Government infrastructure in order to improve public services delivery especially in immigration such as online payments, applications of e-passport, e-visa, and e-permit. It is also recommended that the information security policy and guidelines should be put in place at Government policies in order to make sure the benefits of e-Government are realized fully.
Performance of Variables in Screening for Gestational Diabetes

Abstract Introduction: Gestational diabetes mellitus (GDM) is associated with adverse pregnancy outcomes. The strategies used to screen for GDM vary both internationally and nationally. Therefore, we investigated the performance of the capillary random plasma glucose (RPG) test, maternal body mass index (BMI) and maternal age in predicting GDM. Methods: In a retrospective cohort study, we included pregnant women without pre-existing diabetes or metabolic disease who gave birth in Västernorrland County, Sweden, in 2015–2016. Values for RPG in gestational weeks 23–28 were obtained from obstetric medical records for each pregnancy. The development of GDM was confirmed by evaluating data in the obstetric records. The ability of RPG, maternal BMI, and age to predict GDM was assessed with receiver-operating characteristic curves. Results: In total, 4,698 pregnancies were included in the final statistical analysis. RPG was fairly effective in screening (area under the curve [AUC] 0.73; 95% confidence interval [CI] 0.66–0.80), and BMI performed slightly better (AUC 0.75; 95% CI 0.68–0.82), whereas maternal age performed poorly (AUC 0.61; 95% CI 0.53–0.68). Combining RPG ≥7 and BMI ≥27.9 yielded the best overall sensitivity (75.4%), specificity (70.1%), and AUC (0.75; 95% CI 0.68–0.82). Conclusions: Our results show that the sensitivity of capillary RPG alone in predicting GDM is fair. The combination of RPG with maternal BMI or age showed greater sensitivity. However, none of the screening factors (RPG, BMI, and maternal age), alone or combined, showed sufficiently good performance in predicting GDM.
An Economically Modified Semi-Synthetic Diet for Mass Rearing the Egyptian Cotton Leaf Worm Spodoptera littolaris

This work was aimed to evaluate a simplified semi-synthetic diet based on combination of starch/agar for mass rearing of Spodoptera littoralis. Two modified semi-synthetic diets (A & B) proved successful in maintaining the culture of S. littoralis for five successive generations without apparent adverse effects throughout the insect stages. The mean values of tested biological parameters were determined on the reared insects fed on either of the modified diets. The results showed a higher larval weight, pupal weight, adult emergence, fertility and development index as compared to the agar-based standard diet of Shorey and Hale (1965). Whereas, percentage pupation, survival, fecundity and sex ratio were non-significantly different in the tested treatments. Moreover, the cost of ingredient reduced by 45.6% and 33.3% per one liter of diets A and B, respectively as compared to the agar-based standard diet. The obtained results provide an economically viable diet for mass rearing, thus promising for large-scale production of S. littoralis laboratory culture.
Circulation and transport in the Pearl River Estuary and adjacent shelf : observational and modeling studies

Circulation, hydrographic features and associated transports in the Pearl River Estuary (PRE) as well as over the adjacent shelf are controlled by multi-forcing of the river discharge, tides, and winds. Data from in situ measurements and from a validated three-dimensional, high resolution numerical model have been utilized to investigate the sub-tidal and intra-tidal hydrodynamics in the PRE and the estuary-shelf interaction in different seasons. Our observation results indicate that in summer, freshwater from Pearl River covers the entire estuary in the surface and upper estuary in the bottom. The river plume is formed after the freshwater spreads to eastern part of the shelf by the southwesterly wind-driven coastal current. In winter, discharge from a relative small runoff from the river flows along the west bank of the estuary under Coriolis effect and northeasterly wind forcing. Tidally-driven currents dominate axial circulation in the estuary and greatly modify the transports between the estuary and adjacent shelf. It is found that flood current starts from the bottom at the eastern side of estuary while the ebb current exists at the western side. The strongest stratification occurs in the lower estuary where the river water encounters sea water and the tidal straining effect intensifies during the ebb tides when tidal mixing is relatively weak. Both the model and observation show that the circulation in the PRE is a salt-wedge estuary with a typical two-layer estuarine circulation in summer, and a partially mixed estuary in winter, as a result of seasonal variation of the river discharge. Our analyses based on the processoriented modeling study show that the heat transport between the estuary and adjacent shelf is mainly determined by the volume transport due to small cross-shore temperature gradient, while the salt flux is controlled by both the transport and the cross-shore salinity gradient. Tidal prism varies considerably, due to highly variable ratio of river discharge to tidal volume, which affects strongly the exchanges between the estuary and the adjacent shelf, especially in winter. It is shown that there is an obvious spring-neap variation in the volume, heat and salt transports between the estuary and shelf. The stronger transports occur during neaps. Numerical sensitivity studies indicate that the river discharge plays an important role in controlling the net volume and heat transports between the estuary and the shelf, while the tidal forcing has the largest effect on salt transport in both summer and winter. Monsoonal wind forcing modulates the shelf circulation and affects the seasonal transports between the estuary and shelf as a result of the interaction between the estuarine and shelf dynamic regime. 1 CHAPTER
Adapting TPC-C Benchmark to Measure Performance of Multi-Document Transactions in MongoDB

MongoDB is a popular distributed database that supports replication, horizontal partitioning (sharding), a flexible document schema and ACID guarantees on the document level. While it is generally grouped with "NoSQL" databases, MongoDB provides many features similar to those of traditional RDBMS such as secondary indexes, an ad hoc query language, support for complex aggregations, and new as of version 4.0 multi-statement, multi-document ACID transactions.We looked for a well understood OLTP workload benchmark to use in our own system performance test suite to establish a baseline of transaction performance to enable flagging performance regressions, as well as improvements as we continue to add new functionality. While there exist many published and widely used benchmarks for RDBMS OLTP workloads, there are none specifically for document databases.This paper describes the process of adapting an existing traditional RDBMS benchmark to MongoDB query language and transaction semantics to allow measuring transaction performance. We chose to adapt the TPC-C benchmark even though it assumes a relational database schema and SQL, hence extensive changes had to be made to stay consistent with MongoDB best practices. Our goal did not include creating official TPC-C certifiable results, however, every attempt was made to stay consistent with the spirit of the original benchmark specification as well as to be compliant to all specification requirements where possible.We discovered that following best practices for document schema design achieves better performance than using required normalized schema. All the source code used and validation scripts are published in github to allow the reader to recreate and verify our results.
Aalborg Universitet The Principle of Structural Reciprocity history , properties and design issues

Users may download and print one copy of any publication from the public portal for the purpose of private study or research. You may not further distribute the material or use it for any profit-making activity or commercial gain ? You may freely distribute the URL identifying the publication in the public portal ? Take down policy If you believe that this document breaches copyright please contact us at vbn@aub.aau. dk providing details, and we will remove access to the work immediately and investigate your claim.
Performance Analysis of Frequency Hopping Ad Hoc Communication System With Non-Orthogonal Multiple Access

In this paper, we investigate the downlink performance of frequency hopping Ad Hoc communication system with non-orthogonal multiple access (FH-NOMA Ad Hoc), in which the mobile users are divided into multiple groups defined as NOMA clusters. Each NOMA cluster works on a certain frequency resource block with frequency hopping. Each mobile user in a NOMA cluster can act as NOMA transmitter with equal access probability and serve the rest mobile users with differentiated power allocation. With the considered network model, a stochastic geometry framework is provided to analyze the coverage and data rate performance of the FH-NOMA Ad Hoc network. Expressions for the coverage probability and the average data rate of a typical mobile user are derived. Finally, numerical and Monte Carlo simulations are provided to validate the theoretical analysis. The results reveal that the coverage probability of the FH-NOMA Ad Hoc network can be improved by varying the radius of each NOMA cluster, the number of frequency points, the density of NOMA clusters and user power allocation. Importantly, there is a constraint relationship between the density of NOMA clusters and the number of frequency points.