Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of the Spirulina platensis and Panax ginseng oral supplementation on peripheral blood cells in rats

Les effets d'un traitement oral par Spirulina platensis et par Panax ginseng dans l'eau de boisson ont ete analyses sur 30 rattes Wistar albinos femelles adultes reparties en 3 groupes egaux. Les animaux des 1 er et 2 eme groupes ont ete respectivement traites pendant 30 jours par Spirulina platensis (300 mg/kg/j) et par Panax ginseng (400 mg/kg/j) tandis que le 3 eme groupe a servi de controle. Les numerations erythrocytaire et leucocytaire ainsi que l'hematocrite et l'hemoglo-binemie ont ete determinees par des methodes hemocytometriques sur des echantillons sanguins collectes a 0, 15 et 30 jours et les volumes globulaires moyens (VGM) et les concentrations corpusculaires moyennes en hemoglobine (CCMH) ont ete calculees. Les populations en lymphocytes B et T ont pu etre denombrees en mettant en evidence l'activite a naphthyl acetate esterase (ANAE). Les traitements par Spirulina platensis et par Panax ginseng ont fortement stimule l'erythropoiese et la synthese de l'hemoglobine a J30 et de petites hematies (micro-cytose) tres chargees en hemoglobine (augmentation de la CCMH) ont ete obtenues lors du traitement par Panax ginseng. Le nombre total de leucocytes a considerablement augmente des le 15 eme jour dans les 2 groupes traites. Chez les rattes supplementees par Spirulina platensis, une neutrophilie precoce (a J15) a ete observee. L'ensemble de la population lymphocytaire ainsi que le nombre de cellules T ont augmente progressivement en fonction de la duree du traitement chez tous les animaux supplementes. En outre, Les effets induits par Panax ginseng sur la population lymphocytaire globale et sur celle des lymphocytes T ont ete plus importants que ceux produits par Spirulina platensis. Ces resultats suggerent que ces 2 biomedecines interferent positivement avec les productions cellulaires de la moelle osseuse et avec l'immunite cellulaire et pourraient etre utiles comme traitement adjuvant des cas d'anemie ou d'immunodeficience.
Role of αvβ3 – Integrin and TLR2 in the innate response to Herpes Simplex Virus infectionand Delivery of retargeted oncolytic Herpes Simplex via carrier cells

In the first part of my thesis I studied the mechanism of initiation of the innate response to HSV-1. Innate immune response is the first line of defense set up by the cell to counteract pathogens infection and it is elicited by the activation of a number of membrane or intracellular receptors and sensors, collectively indicated as PRRs, Patter Recognition Receptors. We reported that the HSV pathogen-associated molecular patterns (PAMP) that activate Toll-like receptor 2 (TLR2) and lead to the initiation of innate response are the virion glycoproteins gH/gL and gB, which constitute the conserved fusion core apparatus across the Herpesvirus. Specifically gH/gL is sufficient to initiate a signaling cascade which leads to NF-κB activation. Then, by gain and loss-of-function approaches, we found that αvβ3-integrin is a sensor of and plays a crucial role in the innate defense against HSV-1. We showed that αvβ3-integrin signals through a pathway that concurs with TLR2, affects activation/induction of interferons type 1, NF-κB, and a polarized set of cytokines and receptors. Thus, we demonstrated that gH/gL is sufficient to induce IFN1 and NF-κB via this pathway. From these data, we proposed that αvβ3-integrin is considered a class of non-TLR pattern recognition receptors. In the second part of my thesis I studied the capacity of human mesenchymal stromal cells isolated by fetal membranes (FM-hMSCs) to be used as carrier cells for the delivery of retargeted R-LM249 virus. The use of systemically administrated carrier cells to deliver oncolytic viruses to tumoral targets is a promising strategy in oncolytic virotherapy. We observed that FM-hMSCs can be infected by R-LM249 and we optimized the infection condition; then we demonstrate that stromal cells sustain the replication of retargeted R-LM249 and spread it to target tumoral cells. From these preliminary data FM-hMSCs resulted suitable to be used as carrier cells
DYNAMICAL MEAN-FIELD THEORY OF THE SMALL POLARON

A dynamical mean-field theory of the small polaron problem is presented, which becomes exact in the limit of infinite dimensions. The ground-state properties and the one-electron spectral function are obtained for a single electron interacting with Einstein phonons by a mapping of the lattice problem onto a polaronic impurity model. The one-electron propagator of the impurity model is calculated through a continued fraction expansion, at both zero and finite temperature, for any electron-phonon coupling and phonon energy. In contrast to the ground-state properties, such as the effective polaron mass, which show a continuous behavior as the coupling is increased, spectral properties exhibit a sharp qualitative change at low enough phonon frequency: beyond a critical coupling, one energy gap and then more open in the density of states at low energy, while the high-energy part of the spectrum is broad and can be qualitatively explained by a strong coupling adiabatic approximation. As a consequence, narrow and coherent low-energy subbands coexist with an incoherent featureless structure at high energy. The subbands denote the formation of quasiparticle polaron states. Also, divergencies of the self-energy may occur in the gaps. At finite temperature such an effect triggers an important damping and broadening of the polaron subbands. On the other hand, in the large phonon frequency regime such a separation of energy scales does not exist and the spectrum always has a multipeaked structure.
Precision metrology of weak measurement with a thermal state pointer

Quantum metrology is being gradually studied for weak measurement systems. For weak measurement systems with a thermal state pointer, we find that in the displacement space corresponding to imaginary weak values, the maximal quantum Fisher information (QFI) after the postselection for an accepted event (conversely, the postselection for a rejected event) can attain a level of thermal fluctuation, without surpassing the total QFI, and further, that QFI which increases with increasing temperature can constantly improve measurement precision. These results are much better than those of weak measurement with a pure state (i.e. Gaussian state) pointer. On the other hand, in Kerr nonlinear interaction systems with weak measurement, and by using a thermal state pointer, we obtain in the phase space the accepted postselection and the postselected measurement both achieving the Heisenberg limit of quantum metrology, and showing that weak measurement with thermal states only obtain classical Fisher information (CFI) which increases with increasing temperature and achieves classical-enhanced scaling of N2. Moreover, weak measurement with thermal states has an advantage over that with coherent states or mixed states of light because generating these states with larger uncertainty is limited under current technology, but thermal states with larger uncertainly are very easy to achieve with increasing temperature in nature, such as for optical systems and optomechanical systems.
Autoregressive Model of Channel Transfer Function for UWB Link inside a Passenger Car

This article reports results of channel frequency transfer function measurements inside the passenger compartment of a four seated sedan car. The examined frequency range spans from 3 GHz to 11 GHz and covers the ultra wide band, a promising candidate for future automotive wireless standards. It is found that the complex transfer function may be decomposed into two terms, the first one being a real valued long term trend that characterizes frequency dependency with a power law, and the second term forms a complex correlative discrete series which may be represented via an autoregressive model. The proposed model is validated by comparing the simulated transfer function with the measured data. Simulated values for the coherence bandwidth, power delay profile, and the root mean square delay spread are also in good agreement with the experimental values.
Multi-element Doppler imaging of the CP2 star HD 3980

Diese Diplomarbeit behandelt die ungleichmasige Verteilung der Oberflachenhaufigkeiten von verschiedenen Elementen in der Atmosphare von HD 3980. Der Ursprung dieser Unter- und Uberhaufigkeiten ist atomare Diffusion in den stabilen Atmospharen von magnetischen Ap Sternen wie HD 3980. Um solche Veranderungen zu untersuchen, mussen hochaufgeloste Spektren in verschiedenen Phasen der Rotation des Sterns aufgenommen werden. Die Haufigkeitsverteilung der Elemente ist durch den Doppler-Effekt in den Linienprofilen im Spektrum des Sterns sichtbar. Eine gute Abdeckung der Rotationsphasen ist deshalb unabdingbar. Der erste Schritt hin zur Analyse des Spektrums ist die in Abschnitt 2.2 beschriebene Reduktion der Daten. In weiterer Folge ist es notig eine Modellatmosphare und anschliesend ein synthetisches Spektrum zu berechnen. Indem man die Beobachtung mit der Synthese vergleicht, konnen fur das Doppler Imaging geeignete Bereiche identifiziert werden. Die Bestimmung der atmospharischen Parameter ist in Abschnitt 3.4 beschrieben. Die atmospharischen Parameter wie, e.g., effektive Temperatur, Oberflachenbeschleunigung oder scheinbare Rotationsgeschwindigkeit des Sterns sind grundlegend fur solche Untersuchungen. Die Linienprofilvariationen wahrend der Umdrehung des Sterns wird vom Doppler Imaging Code INVERS12 zu einer Elementhaufigkeitsvereilung invertiert (siehe Abschnitt 4.1 fur weitere Informationen). Die Ergebnisse sind in 3 Gruppen, entsprechend dem Zusammenhang zwischen der Oberflachenverteilung und dem Magnetfeld, eingeteilt. Lithium, Sauerstoff, Mangan, Praseodym und Neodym sind hauptsachlich in der Gegend um die Pole des Magnetfelds konzentriert und unterhaufig in Regionen um den Magnetfeldaquator. Die Flecken mit hoher Silizium-,Lanthan-, Cerium-, Europium- und Gadolinium-Haufigkeit befinden sich zwischen den Magnetfeldpolen und dem Magnetfeldaquator. Lanthan bildet hier eine Ausnahme, da es sogar eine starke Unterhaufigkeit um die Magnetfeldpole besitzt. Ansonsten gibt es fur diese Gruppe keinen offensichtlichen Zusammenhang mit dem Magnetfeld. Kalcium, Chrom und Eisen zeigen eine erhohte Haufung entlang des Rotationsaquators und in der Gegend um die Pole des Magnetfelds. Der Schnittpunkt von Rotations- und Magnetfeldaquators bildet dabei, besonders fur Kalzium und Chrom welche dort unterhaufig sind, eine Ausnahme. Zwischen den theoretisch vorausgesagten und in dieser Arbeit nachgewiesenen Verteilungsmustern konnten keine offensichtlichen Zusammenhange entdeckt werden. Der Grund dafur kann einem Mangel an aktuellen theoretischen Modellen zugeschrieben werden.
Wing In Ground Effect - A New Approach For The Human Powered Helicopter

In this paper a brief overview of the human powered flight will be given at the beginning. The power demand of the most successful human powered fixed wing aircraft will be shown in order to point out the available power problems concerning the design of the rotary wing aircraft. The human ability to perform physical work and therein involved metabolic mechanisms will be shown with their limitations and problems in the accessibility for reliable human power expectations. Furthermore it is not possible to predict the duration of the increased power setting following the constant performance duration. The presentation of analytical calculation method of simplified helicoid will serve as an introduction to the main problem of human powered helicopters – the limited human power source. The invalidity of the common in ground effect models for the purpose of power demand estimation and modest success of realized human powered helicopter designs lead to the alternative approach – the wing in ground effect – as the most promising idea.
Phytochemical Screening and Evaluation of Antibacterial Activity of Rutagraveolens L. - A Medicinal Plant Grown around Mekelle, Tigray, Ethiopia

Ruta graveolens L. is aromatic shrub belongs to family rutaceae. It is ornamental and medicinal plant used in the treatment of inflammation, ulcer, hypotension, reproductive disorders, menstrual problems, parasitic infection, wounds and injuries. The plant extracts showed good antibacterial and antifungal properties. Fresh leaves were collected and leaves were shade dried and powdered. 5 grams of powder extracted with 25 ml different solvents, ethanol, methanol, chloroform and distilled water. Crude solutions were further diluted to 1/10th and 1/100th with DMS. Antibacterial activity against Bacillus subtilis, Pseudomonas aeruginosa, E. coli and Staphylococcus aureus cultures were evaluated by disc diffusion methods on Muller Hinton agar. In our study methanol and chloroform extract recorded better antibacterial activity than ethanol extract at higher dilution. Chloroform and methanol extracts showed more antibacterial activity than ethanol at lower concentration, water extract doesn’t exert any activity. The phytochemical analysis of different solvent extracts of plant show considerable change in the nature of chemicals. Chloroform extract reported maximum number of secondary metabolites than remaining solvents.
The effect of solid cattle manure on soil microbial activity and on plate count microorganisms in organic and conventional farming systems

The diversity and abundance of life is in the soil more copious than in any other ecosystem. Microorganisms play a critical role in soil quality and support development of plants. They stimulate plant growth by facilitating the assimilation of phosphorus and iron, nitrogen fixation, releasing phytohormones, inhibiting root pathogens and synthesizing antibiotics (Glick, 1995). ISSN: 2319-7706 Volume 2 Number 12 (2013) pp. 476-488 http://www.ijcmas. com
The SOAR Gravitational Arc Survey – I. Survey overview and photometric catalogues★

We present the first results of the SOAR (Southern Astrophysical Research) Gravitational Arc Survey (SOGRAS). The survey imaged 47 clusters in two redshift intervals centered at $z=0.27$ and $z=0.55$, targeting the richest clusters in each interval. Images were obtained in the $g'$, $r'$ and $i'$ bands using the SOAR Optical Imager (SOI), with a median seeing of 0.83, 0.76 and 0.71 arcsec, respectively, in these filters. Most of the survey clusters are located within the Sloan Digital Sky Survey (SDSS) Stripe 82 region and all of them are in the SDSS footprint. Photometric calibration was therefore performed using SDSS stars located in our SOI fields. We reached for galaxies in all fields the detection limits of $g \sim 23.5$, $r \sim 23$ and $i \sim 22.5$ for a signal-to-noise ratio (S/N) = 3. As a by-product of the image processing, we generated a source catalogue with 19760 entries, the vast majority of which are galaxies, where we list their positions, magnitudes and shape parameters. We compared our galaxy shape measurements to those of local galaxies and concluded that they were not strongly affected by seeing. From the catalogue data, we are able to identify a red sequence of galaxies in most clusters in the lower $z$ range. We found 16 gravitational arc candidates around 8 clusters in our sample. They tend to be bluer than the central galaxies in the lensing cluster. A preliminary analysis indicates that $\sim 10%$ of the clusters have arcs around them, with a possible indication of a larger efficiency associated to the high-$z$ systems when compared to the low-$z$ ones. Deeper follow-up images with Gemini strengthen the case for the strong lensing nature of the candidates found in this survey.
Essex Finance Centre Working Paper Series Working Paper No 15 : 01-2017 “ Wavelet-based option pricing : An empirical study ” “

In this paper, we adopt a wavelet-based option valuation model and empirically compare the pricing and forecasting performance of this model with that of the stochastic volatility model with jumps and the spline method. Both the in-sample valuation and out-of-sample forecasting accuracy are examined using daily index options in the UK, Germany, and Hong Kong from January 2009 to December 2012. Our results show that the wavelet-based model compares favorably with the other two models and that it provides an excellent alternative for valuing option prices. Its superior performance comes from the powerful ability of the wavelet method in approximating the risk-neutral moment-generating functions.
Chronic Obstructive Pulmonary Disease and Paraoxonase-1 192 and 55 Gene Polymorphisms

ABSTRACT Chronic obstructive pulmonary disease (COPD) is a leading cause of chronic morbidity and mortality. The oxidative stress is increased in COPD patients. Paraoxonase (PON1) in the lung may have a role to protect from oxidative stress. We have investigated a possible relationship between PON1 55 and PON1 192 gene polymorphisms in COPD patients and control subjects. A Total of 62 inpatients of COPD, 45 non-smokers and 35 smokers without COPD were included in the study. The serum levels of PON1 were measured. The PON1 genotypes were determined by PCR amplification of the region containing the polymorphism followed by restriction enzyme digestion. The serum levels of PON1 were significantly low in the COPD patients group (p<0.001). There were no statistical differences between the COPD and control groups for PON1 55 polymorphism. The PON1 192 QQ and QR genotypes occurred with similar frequencies in the COPD and control groups with no significant differences while a significant difference was found between the PON1 192 RR allele frequencies (p< 0.05) of all groups. PON1 192 gene polymorphism may be considered associated with COPD. PON1 polymorphisms and low PON1 activity levels might be considered as an independent risk factor for COPD.
Planetary companions around the metal-poor star HIP 11952

Aims. We carried out a radial-velocity survey to search for planets around metal-poor stars. In this paper we report the discovery of two planets around HIP 11952, a metal-poor star with [Fe/H]=−1.9 that belongs to our target sample. Methods. Radial velocity variations of HIP 11952 were monitored systematically with FEROS at the 2.2 m telescope located at the ESO La Silla observatory from August 2009 until January 2011. We used a cross-correlation technique to measure the stellar radial velocities (RV). Results. We detected a long-period RV variation of 290 d and a short-period one of 6.95 d. The spectroscopic analysis of the stellar activity reveals a stellar rotation period of 4.8 d. The Hipp arcos photometry data shows intra-day variabilities, which give evidence for stellar pulsations. Based on our analysis, the observed RV variations are most likely caused by the presence of unseen planetary companions. Assuming a primary mass of 0.83 M⊙, we computed minimum planetary masses of 0.78 MJup for the inner and 2.93 MJup for the outer planet. The semi-major axes are a1 = 0.07 AU and a2 = 0.81 AU, respectively. Conclusions. HIP 11952 is one of very few stars with [Fe/H]<−1.0 which have planetary companions. This discovery is important to understand planet formation around metal-poor stars.
haracterization of a gene encoding alcohol dehydrogenase in enznidazole-susceptible and-resistant populations of rypanosoma cruzi

Alcohol dehydrogenases (ADH) are a class of oxidoreductases that catalyse the reversible oxidation of ethanol to acetaldehyde. In the human parasite Trypanosoma cruzi the TcADH gene was identified through microarray analysis as having reduced transcription in an in vitro induced benznidazole (BZ)-resistant population. In the present study, we have extended these results by characterizing the TcADH gene from 11 strains of T. cruzi that were either susceptible or naturally resistant to benznidazole and nifurtimox or had in vivo selected or in vitro induced resistance to BZ. Sequence comparisons showed that TcADH was more similar to prokaryotic ADHs than to orthologs identified Leishmania spp. Immunolocalisation using confocal microscopy revealed that TcADH is present in the kinetoplast region and along the parasite body, consistent with the mitochondrial localization predicted by sequence analysis. Northern blots showed a 1.9 kb transcript with similar signal intensity in all T. cruzi samples analysed, except for the in vitro selected resistant population, where transcript levels were 2-fold lower. These findings were confirmed by quantitative real-time PCR. In Western blot analysis, anti-TcADH polyclonal antisera recognised a 42 kDa protein in all T. cruzi strains tested. The level of expression of this polypeptide was approximately 2-fold lower in the in vitro induced benznidazole-resistant strain, than in the susceptible parental strain. The chromosomal location of the TcADH gene was variable, but was not associated with the zymodeme or with the drug resistance phenotype. The data presented here show that the TcADH enzyme has a decreased level of expression in the in vitro induced BZ-resistant T. cruzi population, a situation that has not been lected observed in the in vivo se
Kaposi ’ s sarcoma-associated herpesvirus K 8 protein interacts with hSNF 5

Received 9 July 2002 Accepted 13 November 2002 Kaposi’s sarcoma-associated herpesvirus (KSHV) is a human gammaherpesvirus related to Epstein–Barr virus (EBV) and herpesvirus saimiri. KSHV open reading frame K8 encodes a basic region-leucine zipper protein of 237 aa that homodimerizes. K8 shows significant similarity to the EBV immediate-early protein Zta, a key regulator of EBV reactivation and replication. In this study, a carboxyl-terminal deletion mutant of K8, K8(1–115), that had strong transactivating properties was found. Screening using transcriptionally inactive K8(1–75) showed that K8 interacts and co-localizes with hSNF5, a cellular chromatin-remodelling factor, both in vivo and in vitro. This interaction requires aa 48–183 of hSNF5 and 1–75 of K8. In a yeast expression system, the ability of K8 and K8(1–115) to activate transcription requires the presence of SNF5, the yeast homologue of hSNF5. These data suggest a mechanism by which the SWI–SNF complex is recruited to specific genes. They also suggest that K8 functions as a transcriptional activator under specific conditions and that its transactivation activity requires its interaction with the cellular chromatin remodelling factor hSNF5.
Bean Yield and Soil Parameters as Response to Application of Biogas Residues and Ammonium Nitrate under Different Water Requirements

NAEROBIC digestion is a useful way to treat organic waste matter, resulting in biogas and residue. Two field experiments were carried out for a sandy loam soil under drip irrigation system using faba bean (Vicia faba L.) during 2014/2015 and 2015/2016 seasons at Ismailia Governorate to evaluate the effect of biogas residue (BR) and inorganic fertilizer as ammonium nitrate (AN) individually or in combination with different rates of each other fertilizers and irrigation levels on faba bean production, nutrients uptake and soil fertility after two season of cultivation. The experiment includes two factors; 1 one was N-application with 6 treatments as follows: (1) 100% of N rate as BR, (2) 100% as AN, (3) 75% BR+25% AN, (4) 50% BR + 50 % AN, (5) 25% BR + 75% AN and (6) non-treated (control). The second factor was irrigation levels as follows: 100% from water requirement (WR) and 75% of WR. Main effects of fertilization showed that, the highest plant dry weight, 100seed weight, seed yield were obtained with 100% of BR followed by 25% AN + 75% BR and lowest plant dry weight was found with unfertilized treatment in both seasons. Similar trend occurred with available N, P and K remaining in soil at harvest. Significant positive correlation was found between soil available N, P and K contents and seed N, P and K. Application of biogas residues is of great benefit to plant and increases soil fertility.