Miracle-dz/UniFAR-FTUs huggingface dataset:
The Role of Smart City Concept in Sustainable Urban Planning from Policy Perspective- Case Study of Malmö

Smart city as a concept or term is the contemporary buzzword which is referred as a means to deliver urban sustainability. In recent years, different smart city initiatives have emerged worldwide, which are advocated increasingly by the private and public sectors. However, there has been a considerable amount of critiques by social and urban scholars who question the current understanding and practice of the smart city, raising doubt if the current smart city is sustainable. The most frequently mentioned critiques indicate that the current smart city which does not have a common definition and theoretical foundation is intensively dominated by technical perspective and the role of private sector. This thesis aims to find out how this current understanding and application of smart city concept affect the urban planning practices and urban policy-making. By taking Malmö as a case study and conducting policy analyses, the research shows that this trend leads to the project-based practices which in the absence of strategic and holistic vision toward the smart city as a concept might not fulfil sustainability criteria, cannot be a beneficiary means for sustainable urban planning, and is a poor concept for social sustainability. It shows that although private sector is an integral part of smart city practices, public sector -municipality -needs to take leadership position in defining smart city based on the real city’s demand and integrate it into the urban planning strategies.
reducing clearance mice by − / −-linolenic acid increases the platelet count in ApoE α Dietary

http://bloodjournal.hematologylibrary. org/content/122/6/1026.full. html Updated information and services can be found at: (426 articles) Platelets and Thrombopoiesis  Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary. org/site/misc/rights.xhtml#repub_requests Information about reproducing this article in parts or in its entirety may be found online at: http://bloodjournal.hematologylibrary. org/site/misc/rights.xhtml#reprints Information about ordering reprints may be found online at: http://bloodjournal.hematologylibrary. org/site/subscriptions/index.xhtml Information about subscriptions and ASH membership may be found online at:
patients receiving imatinib for steroid-refractory chronic GVHD Long-term outcome and prospective validation of NIH response criteria

Jacopo Olivieri, Pietro Leoni and Andrea Bacigalupo Bresciani, Roberta Nuccorini, Sara Pascale, Sabrina Coluzzi, Fabrizio Pane, Antonella Poloni, Francesco Onida, Francesca Patriarca, Enzo Pavone, Silvia Svegliati, Armando Gabrielli, Paola Attilio Olivieri, Michele Cimminiello, Paolo Corradini, Nicola Mordini, Roberta Fedele, Carmine Selleri, in 39 patients receiving imatinib for steroid-refractory chronic GVHD Long-term outcome and prospective validation of NIH response criteria
CTGATCAGGACGGTCGGTAT TCTGGCTTCGGTCTCAGTCT CAGATTGGAGCGCATTACCT ATAATCACCTGCGGCATCTT TGGCGTCTGGTGTCAATATC CCAGCATAGTCGAGTCACAGG GACCTTCGAGGATCTGTTCG ATAGACGTCATCGAGCGACA GAACTGTGAAGTGGTTCAACG AGCGAACTCCAGTGGCTTG TTGCTAGTACGGCAACCAGA TGTTGAACAGGACGGTATGG AAGAACACCGCTTGAGTTGG ATGTTCGAGGAACGGTTACG CATCA

We have previously reported that some pseudogenes are expressed in Mycobacterium leprae (M. leprae), the causative agent of leprosy, and that their expression levels alter upon infection of macrophages. We attempted to further examine the expression of pseudogene and non-coding genomic region in M. leprae, in this study. 19 Pseudogenes, 17 non-coding genomic regions, and 21 coding genes expression in M. leprae maintained in the footpads of the hypertensive nude rat (SHR/NCrj-rnu) were examined by reverse transcriptase polymerase chain reaction (RT-PCR). The expression of some of these pseudogenes, non-coding genomic regions and coding genes were also examined in M. leprae from skin smear specimens obtained from patients with lepromatous leprosy by RT-PCR. Transcripts from pseudogenes, non-coding genomic regions and coding genes examined in this study were clearly observed in M. leprae. The expression patterns of some of these transcripts vary greatly among different leprosy patients. These results indicate that some of pseudogenes and non-coding genomic regions are transcribed in M. leprae and analysis of RNA expression patterns including pseudogene and non-coding genomic region in M. leprae may be useful in understanding the pathological states of infected patients. 2009 Elsevier Ltd. All rights reserved.
Solar wind proton reflection at the lunar surface: Low energy ion measurement by MAP‐PACE onboard SELENE (KAGUYA)

Interaction between the solar wind and objects in the solar system varies largely according to the settings, such as the existence of a global intrinsic magnetic field and/or thick atmosphere. The Moon's case is characterized by the absence of both of them. Low energy ion measurements on the lunar orbit is realized more than 30 years after the Apollo period by low energy charged particle analyzers MAP‐PACE on board SELENE(KAGUYA). MAP‐PACE ion sensors have found that 0.1%∼1% of the solar wind protons are reflected back from the Moon instead of being absorbed by the lunar surface. Some of the reflected ions are accelerated above solar wind energy as they are picked‐up by the solar wind convection electric field. The proton reflection that we have newly discovered around the Moon should be a universal process that characterizes the environment of an airless body.
Paul allergy : a report from the Children ' s Oncology Group asparaginase achieves therapeutic activity after pegaspargase Erwinia

http://bloodjournal.hematologylibrary. org/content/122/4/507.full. html Updated information and services can be found at: (285 articles) Pediatric Hematology  (1565 articles) Lymphoid Neoplasia  (2075 articles) Free Research Articles  (3787 articles) Clinical Trials and Observations  Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary. org/site/misc/rights.xhtml#repub_requests Information about reproducing this article in parts or in its entirety may be found online at: http://bloodjournal.hematologylibrary. org/site/misc/rights.xhtml#reprints Information about ordering reprints may be found online at: http://bloodjournal.hematologylibrary. org/site/subscriptions/index.xhtml Information about subscriptions and ASH membership may be found online at:
"comets importing change of Times and States": ephemerae and process among the Tabwa of Zaire

Ephemeral phenomena, especially irregular ones like comets, are often neglected by anthropologists, since their brevity would appear to reduce their relevance to and impact on society as long-term process. The study of ephemerae, with that of anomalies and monsters, has been deemed a “bootless sort of wisdom” by many over the centuries. ’ Yet, in the apparition of comets as viewed and understood by the Tabwa of Zaire, an opportunity exists to reflect upon how elements of thought available from explanations of more usual and regular events may be assembled to describe a startlingly different phenomenon. Several issues of theoretical and philosophical importance may be raised as a consequence. The Tabwa of southeastern Zaire live along the shores and upon the plateaus southwest of Lake Tanganyika. The vegetation of their area, in most places the distanced trees and high grass of Brachystegia woodland, does not obscure their view of the heavens (as might the canopy of denser forest). Yet Tabwa, like most other Central Africans, seem to have paid little attention to the stars (although c f . Roberts 1981). The swathes of comets, by contrast, intrigued many Tabwa as they have mankind everywhere over the years (see Lagercrantz 1964). Several turn-of-the-century accounts of comets as perceived by Tabwa exist in
Governance and Risk–Value Constructions in Closing Loops of Rare Earth Elements in Global Value Chains

This article addresses a research gap on the challenges—specifically risk and value—connected to realizing the potential for closing loops for rare earth elements (REE). We develop an analytical framework from conceptual elements of the global value chain (GVC) framework and the relational theory of risk to examine several empirical REE industry cases for loop closure. The aim of the paper is to identify how risk–value relationships are constructed by different actors as governance structures form in transactions prior to price setting and how these have impacts on the closure of REE loops. Often, REE loops are not closed, and we find that constructions of the risk–value relationship by industrial actors and by government agencies are unstable as they pursue different motivations, consequently hindering REE loop closure in GVCs. In light of this, we propose that governments mediate against the construction of risk–value relationships by facilitating information on the characteristics of end-of-life materials that qualify these for re-entry into loops.
Measuring teacher and school effectiveness at improving student achievement in Los Angeles elementary schools

This study uses longitudinal student-level test score data to examine the effectiveness of elementary teachers and schools in Los Angeles. The results show that teacher effectiveness varies widely both across the Los Angeles school district and within district schools. Controlling for student background and preparation, we find only modest difference across schools in improving student achievement. We explore the sensitivity of teacher and school effectiveness measures to alternative regression controls. We find that teacher and school effectiveness measures are relatively insensitive to detailed controls for student and peer heterogeneity.
onstruction , characterization and evaluation of the protective fficacy of the Streptococcus suis double mutant strain

Streptococcus suis serotype 2 (S. suis 2) causes sepsis and meningitis in piglets and humans, and results in one of the most serious bacterial diseases affecting the production of commercial pigs around the world. Due to the failure of the current inactivated vaccine to protect against the disease, development of a new attenuated live vaccine against S. suis 2 by deleting essential virulence factors is urgently needed. We have previously reported the construction and characterization of an SsPep single gene deletion mutant strain SsPep based on S. suis 2. Our previous results have shown that SsPep plays a critical role in the pathogenesis of S. suis 2. In this study, a precisely defined double-deletion mutant SsPep/ SsPspC of S. suis 2 without antibiotic-resistance markers was constructed based on SsPep, and the levels of virulence of the wild-type (WT) and SsPep/ SsPspC were compared in a mouse experimental infection model. We demonstrated that the double mutant SsPep/ SsPspC was less virulent than the WT, and could induce a ive vaccine noticeable antibody response. Analysis of IgG subclasses (IgG1 and IgG2a) indicated that both Th1 and Th2 responses were induced by SsPep/ SsPspC, although the IgG2a (Th1) response predominated over the IgG1 (Th2) response. Moreover, SsPep/ SsPspC could confer 90% protective efficacy against challenge with a lethal dose of fully virulent S. suis 2. Taken together, these data demonstrate that SsPep/ SsPspC can be used as an effective live vaccine and provide a novel strategy against infection of S. suis 2. © 2014 Elsevier GmbH. All rights reserved.
Environmental management decision-making in certified hotels

This paper analyses environmental decision-making against two axes, motivations and decision-making processes, to understand the reasons for pro-environmental behaviour by the managements of Spanish Eco-management and Audit Scheme (EMAS)-certified hotels. Mixed methods were used to study perceptions of EMAS and reasons for being certified, with current and lapsed EMAS-certified firms triangulated against expert interviews and documentary evidence. Four groups of hotels were differentiated: Strategic hotels (22%) (with high levels of integrated environmental management), Followers (48%), Greenwashers (11%) and Laggers (19%) (with low levels of integrated environmental management). Most hotels were found to be internally driven in their purpose and ad hoc in their decision-making, with limited understanding of externally driven benefits and motivation for more systematic management systems. This questions the success of EMAS as both a continuous improvement management and as a market-based regulation tool for hotels. Few hotels overall related high environmental standards to the possibilities of gaining market advantage: most wished to avoid legal challenges. The paper also illustrates the ways in which hotels opportunistically switch certification systems to get what they see as a better deal.
Response to reviewers ’ comments on “ Sensitivity analysis of an updated bidirectional air-surface exchange model for mercury vapor ”

We appreciate the helpful comments provided by three reviewers to our paper and we have incorporated their recommendations in the revised manuscript. We appreciate the reviewers for providing the very detailed and constructive remarks. Our point-by-point response to the reviewer' comments is given below. The corresponding changes relating to the reviewers' comments have also been indicated in the response. I hope that the revised manuscript meets the publication standards of Atmospheric Chemistry & Physics.
Fraction of bolometric luminosity absorbed by dust in DustPedia galaxies

Aims. We aim to study the fraction of stellar radiation absorbed by dust, fabs, in 814 galaxies of different morphological types. The targets constitute the vast majority (93%) of the DustPedia sample, including almost all large (optical diameter larger than 1′), nearby (v ≤ 3000 km s−1) galaxies observed with the Herschel Space Observatory. Methods. For each object, we modelled the spectral energy distribution from the ultraviolet to the sub-millimetre using the dedicated, aperture-matched DustPedia photometry and the Code Investigating GALaxy Evolution (CIGALE). The value of fabs was obtained from the total luminosity emitted by dust and from the bolometric luminosity, which are estimated by the fit. Results. On average, 19% of the stellar radiation is absorbed by dust in DustPedia galaxies. The fraction rises to 25% if only late-type galaxies are considered. The dependence of fabs on morphology, showing a peak for Sb-Sc galaxies, is weak; it reflects a stronger, yet broad, positive correlation with the bolometric luminosity, which is identified for late-type, disk-dominated, high-specific-star-formation rate, gas-rich objects. We find no variation of fabs with inclination, at odds with radiative transfer models of edge-on galaxies. These results call for a self-consistent modelling of the evolution of the dust mass and geometry along the build-up of the stellar content. We also provide template spectral energy distributions in bins of morphology and luminosity and study the variation of fabs with stellar mass and specific star-formation rate. We confirm that the local Universe is missing the high fabs, luminous and actively star-forming objects necessary to explain the energy budget in observations of the extragalactic background light.
Transcranial Magnetic Stimulation in the Treatment of Tinnitus

Tinnitus is a disturbing noise that is heard without any hearing stimulus, affects the quality of life of the individual, and leads to psychosocial problems. Its prevalence characteristically increases with aging. It is seen in 33% of the general population. Pathophysiology of tinnitus known to accompany nearly all disorders in auditory system has not been fully understood; therefore, there are some difficulties in evaluation and treatment thereof. Despite the restrictive factors of tinnitus treatment, progress in auditory neuroscience provides a positive view of tinnitus treatment. Transcranial magnetic stimulation (TMS) is a method based on the stimulation of neuronal tissue without depending on the transfer of electrical current by means of electrodes or the skin. TMS is used in the treatment of various diseases with developing neuroscience. In the recent years, the number of studies on TMS application with repetitive low frequency for the treatment of tinnitus has increased, and most of these studies have given successful results. Repetitive use of TMS in tinnitus is very novel; however, it is commonly used in psychiatric disorders, especially in the treatment of drugresistant depression. The chapter shows that low-frequency repetitive TMS (rTMS) is useful in the treatment of chronic tinnitus.
PLATELETS AND THROMBOPOIESIS Allele-speci fi c DNA methylation reinforces PEAR 1 enhancer activity

• Rs12041331 is the first functional CpG-SNP related to platelet function whose regulatory mechanism depends on DNA methylation. • Rs12041331 marks allelespecific methylation at the CpG island encompassing the first untranslated exon during megakaryopoiesis. Genetic variation in the PEAR1 locus is linked to platelet reactivity and cardiovascular disease. The major G allele of rs12041331, an intronic cytosine guanine dinucleotide-single-nucleotide polymorphism (CpG-SNP), is associated with higher PEAR1 expression in platelets and endothelial cells than the minor A allele. The molecular mechanism underlying this difference remains elusive. We have characterized the histonemodification profiles of the intronic region surrounding rs12041331 and identified H3K4Me1 enhancer-specific enrichment for the region that covers the CpG-SNP. Interestingly, methylation studies revealed that the CpG site is fully methylated in leukocytes of GG carriers. Nuclear protein extracts from megakaryocytes, endothelial cells, vscontrolHEK-293cellsshowa3-foldhigheraffinity for themethylatedGallele compared with nonmethylated G or A alleles in a gel electrophoretic mobility shift assay. To understandthepositiverelationshipbetweenmethylationandgeneexpression,westudiedDNA methylationat 4different lociofPEAR1during invitromegakaryopoiesis.Duringdifferentiation, the CpG-SNP remained fully methylated, while we observed rapid methylation increases at the CpG-island overlapping the first 59-untranslated region exon, paralleling the increased PEAR1 expression. In the same region, A-allele carriers of rs12041331 showed significantly lower DNA methylation at CGI1 compared with GG homozygote. ThisCpG-islandcontainsbindingsites for themethylation-sensitive transcription factorCTCF,whosebinding is known toplay a role in enhancer activation and/or repression. In conclusion, we report themolecular characterization of the first platelet function-relatedCpGSNP, ageneticpredisposition that reinforcesPEAR1enhancer activity throughallele-specificDNAmethylation. (Blood. 2016;128(7):1003-1012)
GINI DP 66: Income Inequality in Nations and Sub- national Regions, Happiness and Economic Attitudes

Impact exerted by income inequality on happiness and etatist (interventionist) versus liberal (pro free- market) economic attitudes are analyzed. Income inequality in different countries reduces happiness, understood as public satisfaction with material standard of living and with life as a whole. The results suggest also that income inequality, measured by GINI coefficients, calculated for representative samples of both sub-national (regional) and national populations, decreases public support for saving on social programs and increases public support for economic intervention by the governments. Two kinds of multi- level regression analysis (individual and national as well as individual and regional) bring similar results in this respect.
INCREASED BRAIN IRON DEPOSITION IN SCD PATIENTS 1 Title : Increased brain iron deposition in patients with sickle cell disease : an MRI quantitative susceptibility mapping study Short title : Increased brain iron deposition in SCD patients

Authors: Xin Miao, Soyoung Choi, Benita Tamrazi, Yaqiong Chai, Chau Vu, Thomas D. Coates, and John C. Wood Department of Biomedical Engineering, University of Southern California, Los Angeles, California, USA; Neuroscience Graduate Program, University of Southern California, Los Angeles, California, USA; Division of Cardiology, Children’s Hospital Los Angeles, Los Angeles, California, USA; Department of Radiology, Children’s Hospital Los Angeles, Los Angeles, California, USA; and Hematology Section, Children’s Center for Cancer, Blood Diseases and Bone Marrow Transplantation, Children’s Hospital Los Angeles, Los Angeles, California, USA
– “ even criminals need law and order ”

We present a theoretical model postulating that the relationship between crime and governance is “hump‐shaped” rather than linearly decreasing. State failure, anarchy and a lack of infrastructure are not conducive for the establishment of any business. This includes illegal businesses, as criminals need protection and markets to convert loot into consumables. At the bottom end of the spectrum, therefore, both legal business and criminal gangs benefit from improved governance, especially when this is delivered informally. With significant improvements in formal governance criminal activities decline. We use data from the International Maritime Bureau to create a new dataset on piracy and find strong and consistent support for this non‐linear relationship. The occurrence, persistence and intensity of small‐scale maritime crime are well approximated by a quadratic relationship with governance quality. Organised crime benefits from corrupt yet effective bureaucrats, and informally governed areas within countries.
IMiDs through loss of Ikaros and Aiolos primes myeloma cells for daratumumab mediated killing by upregulation of CD 38

Recent studies have demonstrated that the immunomodulatory drugs (IMiDs) lead to the degradation of the transcription factors Ikaros and Aiolos. However, why their loss subsequently leads to multiple myeloma (MM) cell death remains unclear. Using CRISPRCas9 genome editing, we have deleted IKZF1/Ikaros and IKZF3/Aiolos in human MM cell lines to gain further insight into their downstream gene regulatory networks. Inactivation of either factor alone recapitulates the cell intrinsic action of the IMiDs, resulting in cell cycle arrest and induction of apoptosis. Furthermore, evaluation of the transcriptional changes resulting from their loss demonstrates striking overlap with lenalidomide treatment. This was not dependent on reduction of the IRF4-MYC “axis”, as neither protein was consistently downregulated despite cell death occurring and overexpression of either factor failed to rescue for Ikaros loss. Importantly Ikaros and Aiolos repress the expression of interferon stimulated genes (ISGs), including CD38, and their loss led to the activation of an interferon-like response, contributing to MM cell death. Ikaros/Aiolos repressed CD38 expression through interaction with the nucleosome remodelling and deacetylase complex in MM. IMiD-induced loss of Ikaros or treatment with interferon resulted in an upregulation of CD38 surface expression on MM cells, priming for daratumumab induced NK cell mediated antibody-dependent cellular cytotoxicity. These results give further insight into the mechanism of action of the IMiDs, and provide mechanistic rationale for combination with anti-CD38 monoclonal antibodies. For personal use only. on September 19, 2018. by guest www.bloodjournal. org From