Miracle-dz/UniFAR-FTUs huggingface dataset:
Repression of Manduca sexta ferritin synthesis by IRP1/IRE interaction

Mammalian ferritin subunit synthesis is controlled at the translational level by the iron regulatory protein 1 (IRP1)/iron responsive element (IRE) interaction. Insect haemolymph ferritin subunit messages have an IRE in the 5′‐untranslated region (UTR). We have shown that recombinant M. sexta IRP1 represses the in vitro translation of both the heavy and light chain ferritin subunits from this species without altering transcription. Deletion of either the 5′‐UTR or the IRE from the mRNA abolishes IRP1 repression. Our studies indicated that the translational control of ferritin synthesis by IRP/IRE interaction could occur in insects in a manner similar to that of mammals. To our knowledge, this is the first report of the control of insect ferritin synthesis by IRP1/IRE interaction. Furthermore, this is the first indication that the synthesis of a secreted ferritin subunit can also be controlled in this manner.
Double dissociation of the effects of lesions of basolateral and central amygdala on conditioned stimulus‐potentiated feeding and Pavlovian‐instrumental transfer

Pavlovian conditioned stimuli (CSs) for food can enhance both the performance of instrumental responses that earn food (Pavlovian‐instrumental transfer; PIT) and the consumption of food itself (CS‐potentiated feeding). After a single phase of Pavlovian training, each rat was tested in both PIT and potentiated feeding tasks. Rats with lesions of the central nucleus of the amygdala failed to exhibit PIT but showed normal CS‐potentiated feeding. By contrast, rats with lesions of the basolateral amygdala showed normal PIT but failed to display CS‐potentiated feeding. Performances in a variety of comparison conditions suggested that both lesion effects reflected impairment of acquired motivational functions, rather than with attentional processes or the display of specific learned responses. Implications of the double dissociation of these two aspects of Pavlovian conditioned incentive motivation for amygdala function in associative learning are considered.
Effects of Glacial Meltwater in the GISS Coupled Atmosphere-Ocean Model : Part I : North Atlantic Deep Water Response

Varying magnitudes of freshwater input through the St. Lawrence are added to different versions of the GISS coupled atmosphere-ocean model. The results show a generally linear response in percentage North Atlantic Deep Water (NADW) reduction to the volume of water added without any obvious threshold effects. When the estimated best-guess freshwater input for the Allerod-Younger Dryas interval is added, only small reductions in NADW production occur in less than a century, with complete cessation requiring more than 300 years. If the ocean circulation was weaker in the Allerod preceding the Younger Dryas, somewhat larger percentage reductions occur, although it would still take 150–200 years for a complete shutdown. The freshening is aided by a positive feedback associated with the reduction in evaporation relative to precipitation in the North Atlantic, amounting to some 20–30% of the added freshwater runoff. When the freshwater input is stopped after complete NADW shutdown, NADW production does not resume. With complete NADW cessation, cooling eventually occurs throughout the Northern Hemisphere, including regions where it is not thought to have arisen during the Younger Dryas, and the globe cools by 1◦C due primarily to the sea ice albedo feedback; while in many regions the observed cooling is reproduced, the cooling in Greenland is much less than is estimated. With only 50% NADW cessation, cooling is primarily circum-North Atlantic. No rapid warming is seen in response to freshwater cessation. The sensitivity displayed here for NADW reduction due to freshwater input from the St. Lawrence is roughly similar to that associated with increased precipitation accompanying global warming in the next century, so a similar sensitivity may arise with Younger Dryas freshwater inputs from other suspected locations (Greenland, Europe).
An Update on Minimally Invasive Adrenalectomy

Adrenal tumors require careful clinical and biochemical evaluation with appropriate imaging to determine malignancy or functional status. Tumors that are suspicious or confirmed for malignancy or hormone-secreting require adrenalectomy. This review discusses adrenal gland anatomy, physiology, and pathology, indications for adrenalectomy, preoperative management, and an update on surgical approaches with an emphasis on minimally invasive techniques. We describe the transabdominal and retroperitoneoscopic approaches to adrenalectomy and briefly discuss extensions of minimally invasive surgery including robotic-assisted and single portadrenalectomy.
DUCTILITY ANALYSIS ON THE POST-PEAK BEHAVIOR OF SELF-COMPACTING FIBER REINFORCED CONCRETE ( SCFRC ) BEAMS SUBJECTED TO SHEAR

It is well known that steel fibers have an efficient effect on the shear behavior, enhancing its ultimate load and guarantying the minimum shear reinforcement required by the current Codes. Steel fibers make possible a more distributed cracking pattern, where shear cracks have smaller crack widths and less separated one to each other. To analyze the fiber contribution to shear capacity, Codes usually consider only the residual concrete strength at a 2.5 mm crack opening in the flexural test (fR3) but, it is possible to reach a similar fR3 testing concretes with very different post-cracking behavior. In this paper, shear behavior on self-compacting fiber reinforced concrete (SCFRC) beams is analyzed, paying attention to the serviceability limit state (SLS), the ultimate limit state (ULS), and also analyzing the ductility on the load / deflection and load / shear crack opening behavior of these beams. To achieve the objectives, an experimental program consisting of SCFRC double-T beams was designed. Beams were 2400mm long, with a double-T cross-section 350mm height and web width equal to 90mm. The main parameters of study were: concrete compressive strength level (30, 50, 80MPa) and steel fibers quality (using fibers with different strength levels, lengths, and aspect ratio (length/diameter)). The amount of steel fibers (50kg/m 3 ) was kept constant. Beams without fibers were produced to be utilized as a reference. Studying all the parameters, the post-peak behavior analysis under shear loadings has been possible.
Coronary MR imaging: breath-hold capability and patterns, coronary artery rest periods, and beta-blocker use.

PURPOSE To prospectively evaluate breath-hold capability and patterns, coronary artery rest periods, and beta-blocker use in coronary magnetic resonance (MR) imaging. MATERIALS AND METHODS Ethics committee approval and informed consent were obtained. In 210 consecutive patients (mean age, 61.8 years +/- 10.3 [standard deviation]; 146 men, 64 women), breath-hold patterns and maximal capability were assessed at expiration with dynamic navigator MR imaging (temporal resolution, 1 second). Left coronary artery (LCA) and right coronary artery (RCA) rest periods were determined at transverse cine imaging (steady-state free precession, retrospective gating, 40 phases per cycle). Before and after beta-blockade, rest periods were assessed in 25 additional patients (mean age, 61.4 years +/- 7.1; 20 men, five women). Differences were tested within groups with paired Student t test and between groups with unpaired Student t test (continuous variables) and chi(2) test (categoric variables). Pearson correlation was used to test the relationship between rest period and heart rate. RESULTS Four distinct breath-hold patterns, characterized by diaphragmatic motion, were identified: pattern 1, steady plateau (55% of patients); 2, initial drift followed by plateau (12%); 3, continuous drift (19%); and 4, irregular, unsteady behavior (14%). Mean breath-hold capability with patterns 1 and 2 was 29 seconds +/- 13 (range, 10-64 seconds). The rest period of LCA was longer than that of RCA (163 msec +/- 75 vs 123 msec +/- 60; P < .01) and began earlier in the cardiac cycle (521 msec +/- 149 vs 540 msec +/- 160; P < .01); In a minority of patients, LCA rest period began later (21%) or was shorter (14%). With no pharmacologic intervention, correlation between rest period duration and heart rate was weak (LCA, r = -0.52; RCA, r = -0.38; P < .01). However, beta-blockade significantly lowered heart rate (61.3 beats/min +/- 7.2 vs 82.6 beats/min +/- 12.5, P < .001) and increased rest duration (LCA, 201.8 msec +/- 83.6 vs 111.8 msec +/- 44.55; RCA, 134.8 msec +/- 57.3 vs 83.1 msec +/- 35.8; P < .001). CONCLUSION In 33% of patients (patterns 3 and 4), breath-hold pattern was unsuitable for high-spatial-resolution breath-hold MR imaging. LCA and RCA rest periods showed large variability in starting point and duration, with no correlation to heart rate.
Salmonella enterica Serovar Typhimurium Can Detect Acyl Homoserine Lactone Production by Yersinia enterocolitica in Mice

ABSTRACT LuxR-type transcription factors detect acyl homoserine lactones (AHLs) and are typically used by bacteria to determine the population density of their own species. Escherichia coli and Salmonella enterica serovar Typhimurium cannot synthesize AHLs but can detect the AHLs produced by other bacterial species using the LuxR homolog, SdiA. Previously we determined that S. Typhimurium did not detect AHLs during transit through the gastrointestinal tract of a guinea pig, a rabbit, a cow, 5 mice, 6 pigs, or 12 chickens. However, SdiA was activated during transit through turtles colonized by Aeromonas hydrophila, leading to the hypothesis that SdiA is used for detecting the AHL production of other pathogens. In this report, we determined that SdiA is activated during the transit of S. Typhimurium through mice infected with the AHL-producing pathogen Yersinia enterocolitica. SdiA is not activated during transit through mice infected with a yenI mutant of Y. enterocolitica that cannot synthesize AHLs. However, activation of SdiA did not confer a fitness advantage in Yersinia-infected mice. We hypothesized that this is due to infrequent or short interactions between S. Typhimurium and Y. enterocolitica or that the SdiA regulon members do not function in mice. To test these hypotheses, we constructed an S. Typhimurium strain that synthesizes AHLs to mimic a constant interaction with Y. enterocolitica. In this background, sdiA + S. Typhimurium rapidly outcompetes the sdiA mutant in mice. All known members of the sdiA regulon are required for this phenotype. Thus, all members of the sdiA regulon are functional in mice.
SOME PEOPLE HEED ADVICE LESS THAN OTHERS 2 Some People Heed Advice Less Than Others : Agency ( but not Communion ) Predicts Advice Taking Advice is an important ingredient in human interaction

Across three studies (total N = 793), we investigated the link between two fundamental dimensions of personality, agency and communion, and advice taking in quantity estimation tasks. We complemented the analyses of the individual studies with meta-analyses across all three studies in order to gain insight into the robustness of our core results. In line with our expectations, agency was associated with less advice taking, and this effect was mediated by individuals’ perceptions of their own competence. Contrary to what we expected, we did not find consistent evidence that communion systematically relates to advice taking. Analyses of judges’ initial accuracy further suggested that agentic judges’ lower willingness to heed advice was justified by greater initial accuracy as compared to their less agentic peers. Our data, thus, provide evidence of individual differences in advice taking and shed some light on the question which individuals are more inclined to heed advice than others.
Object Segmentation from Motion with Dense Feature Matching

To enable fast deployment and long-term operation, service robots must have the capability to discover and learn about novel objects even in previously unseen parts of the environment. Since most mobile robots are interested in objects for their potential for manipulation, one good way for a robot to find objects is to attempt to manipulate the scene, then decide what parts of the scene the manipulation affected. We use motion as a cue to segment objects and register views of them before and after an attempted manipulation. Many common objects are not distinctively textured, so we match local descriptors for densely sampled points rather than sparse keypoints. Our method performs both dense segmentation and motion estimation for objects undergoing full 3-D rigid motion.
Exogenous Pentraxin 3 Restores Antifungal Resistance and Restrains Inflammation in Murine Chronic Granulomatous Disease1

Chronic granulomatous disease (CGD) is a primary immunodeficiency characterized by life-threatening bacterial and fungal infections and hyperinflammation. The susceptibility to aspergillosis in experimental CGD (p47phox−/− mice) is associated with the failure to control the inherent inflammatory response to the fungus and to restrict the activation of inflammatory Th17 cells. We assessed whether pentraxin (PTX)3, a member of a family of multimeric pattern-recognition proteins with potent anti-Aspergillus activity, could limit pathogenic inflammation in p47phox−/− mice by curbing the IL–23/Th17 inflammatory axis in response to the fungus. We found that the production of PTX3 was delayed in CGD mice in infection but exogenous administration of PTX3 early in infection restored antifungal resistance and restrained the inflammatory response to the fungus. This occurred through down-regulation of IL-23 production by dendritic cells and epithelial cells which resulted in limited expansion of IL-23R+ γδ+ T cells producing IL-17A and the emergence of Th1/Treg responses with minimum pathology. Thus, PTX3 could be therapeutically used for the exploitation of NADPH-independent mechanism(s) of antifungal immune protection with limited immunopathology in CGD.
ENGLISH SKILLS, LABOR MARKET STATUS AND EARNINGS OF TURKISH WOMEN1

In this paper, we investigate the effect of the level of English skills on the labour market outcomes of Turkish women, using data from the Adult Education Survey of 2007. By adopting a bivariate equation framework, we jointly model the effect of English skills on labour market status and, conditional on being a wage earner, on monthly earnings and occupational status. The multinomial equation that explains labour market status allows for a different effect of language knowledge on the probability of being employed, unemployed but actively looking for a job, an unpaid family worker or involved in household tasks. The results indicate that being proficient in English is conditionally associated with a higher probability of being employed as a wage earner and, to a lesser extent, unemployed but looking for a job, whereas it decreases the likelihood of being involved in household tasks. Moreover, there is a significant conditional correlation between having a high level of skills in English and earnings, which is only modestly reduced when job-related variables and (especially) occupation dummies are included as additional controls. Indeed, being proficient in English barely affects occupational status when selection into employment status is controlled for. Therefore, the knowledge of foreign languages (in this case English) seems to stimulate labour market participation and earnings capacity, but does not substantially affect the occupational position of women in the Turkish labour market.
Improving Anaphylaxis Management by Health Care Professional Education and Practical Skills Training in a Regional Centre

Professor David Brewster’s article on John Boulton’s new book highlights the attention the book has received from paediatricians interested in the health of Indigenous children. Written from the shared perspectives of paediatrician and anthropologist, the book allows for greater acknowledgement of the cultural and historical factors influencing the health of Aboriginal children and young people today. Brewster notes that mainstream Australia cannot address ‘historical injustices’, and presumably also reduce the health gap for Aboriginal children and young people, such as the highest rates of youth suicide in the world in the Kimberleys, without ‘Aboriginal partnership’. However, he also notes in his conclusion that ‘ultimately it is Aboriginal communities and language groups which need to institute change, which preserves the key aspects of their culture while encouraging improvements in child health outcomes’. The Paediatric Policy and Advocacy Committee (RACP) wholly agrees that partnerships between Aboriginal and Torres Strait Islander and non-Indigenous Australians are fundamental to addressing child health inequities. It is also vital for non-Indigenous groups to advocate that there are Indigenous-led solutions to these issues; to actively listen and learn and support our partners. Readers may be interested to know that the RACP has commenced work on a policy on Indigenous child health that seeks to understand the health and well-being of Indigenous children and young people in Australia and New Zealand, their relationship to culture, country and community and how we as paediatricians can contribute to improved health outcomes. Most importantly, the development of this policy is being led by an Indigenous paediatrician, Dr Danny De Lore from Rotorua, with strong representation from Indigenous Fellows and community members from Australia and New Zealand. Partnerships such as these are fundamental to improving the health and well-being of our Indigenous children and young people.
Effect of Inclusion of Prawn and Mola on Water Quality and Rice Production in Prawn-Fish-Rice Culture System

A long term experiment for a period of sixteen weeks was conducted from August to November, 2005 to observe the effects of inclusion of prawn (Macrobrachium rosenbergii) and mola (Amblypharyngodon mola ) on water quality and rice production. To achieve the target four treatments each with three replications were set in the experiment. In all treatments prawn was stocked with mola in the rice field. The stocking densities of prawn were 10,000, 15,000, 20,000 and 25,000/ha in treatments T1, T2, T3 and T4 respectively. The stocking density of mola was 20,000/ha in all the treatments. All rice plots were fertilized with urea (200 kg/ha), TSP (150 kg/ha) and MP (75 kg/ha). The mean values of water quality parameters such as temperature, transparency, dissolved oxygen, pH, alkalinity, ammonia, nitrate-nitrogen, phosphate-phosphorus and chlorophyll-a in all the plots showed very small variations among the different treatments except chlorophyll-a which was relatively higher in all treatments. All the parameters were found within the suitable ranges for prawn and mola culture and with respect to cultural suitability, prawn performed comparatively higher growth rate and survival rate in treatment T2, where stocking density was 15,000/ha.The highest production (456.16kg/ha) of prawn was also recorded in the treatment-T2 compared to other treatments . The yields of rice grain recorded were 3.71 mt/ha, 2.88 mt/ha, 3.33 mt/ha and 3.04 mt/ha in T1, T2, T3 and T4 respectively. The highest yield of rice grain obtained was 3.71 mt/ha in treatment-1. The study provided evidence that the introduction of prawn and mola in rice fields has profound impacts on the availability of nutrients in the water and soil which ultimately increase the yield of rice grain and straw and at the same time provides an additional yield of prawn and mola from the same land and ultimately the rural poor farmers would be benefited economically and nutritionally by adopting rice-prawn-mola integrated culture system.
omparison of bioactive compounds content in leaf extracts of assiflora incarnata , P . caerulea and P . alata and in vitro cytotoxic otential on leukemia cell lines

Passiflora caerulea L. , P. alata Curtis and P. incarnata L. (synonym for P. edulis Sims), are the most popular representatives of the Passiflora genus in South America. In recent years, a growing attention is paid to the biological activity and phytochemical profiles of crude extracts from various species of Passiflora in worldwide. The aim of this study was to evaluate and to compare of anti-leukemic activity of the dry crude extracts from leaves of three Passiflora species from greenhouse of Poland in two human acute lymphoblastic leukemia cell lines: CCRF-CEM and its multidrug resistant variant. Two systems of liquid chromatography in order to assessment of phytochemical composition of extracts were applied. Extracts of P. alata and P. incarnata showed the potent inhibitory activity against human acute lymphoblastic leukemia CCRF-CEM, while P. caerulea not showed activity (or activity was poor). Despite similarities in quality phytochemical profile of extracts from P. caerulea and P. incarnata, differences in quantity of nti-leukemic activity chemical compounds may determine their various pharmacological potency. For the activity of P. alata extract the highest content of terpenoids and a lack of flavones C-glycosides are believed to be crucial. Summarizing, the crude extract from P. alata leaves may be considered as a substance for complementary therapy for cancer patients. © 2018 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda. This is an open he CC access article under t
STRUCTURE AND PROPESTIES OF SUB-ZERO PROCESSED VANADIS 6 P / M LEDEBURITIC TOOL STEEL

The P/M Vanadis 6 cold work steel was austenitized, quenched and tempered at various combinations of processing parameters. For selected sets of specimens, also sub-zero period, made at different temperatures and processing dwell times was inserted between quenching and tempering. The microstructure and mechanical properties have been investigated as a function of austenitizing temperature, parameters of sub-zero processing and tempering. As-quenched structure is composed of martensite, retained austenite and carbides. Sub-zero processing led to the decrease of the retained austenite amount and increase of tetragonality of the martensitic lattice. Therefore, the as-quenched hardness of sub-zero processed samples was than that of no sub-zero processed steel. On the other side, the use of sub-zero period results in a slight hardness decrease after tempering. Furthermore it was found that the three point bending strength, decreased markedly with increased austenitizing temperature. The lowering of bending strength with increasing austenitizing temperature can be considered as natural because of the austenitic grain growth. The situation for sub-zero treated steel seems to be more complex. Bending strength for the material processed at -90°C was lower while the sub -zero processing at -196°C led generally to increas e of the bending strength.