Miracle-dz/UniFAR-FTUs huggingface dataset:
The Statutory Homelessness System in England: A Fair and Effective Rights-Based Model?

The statutory homelessness system, first established by the Housing (Homeless Persons) Act 1977, is an important but frequently criticised element of the British welfare state. Drawing upon a survey of 2053 ‘statutorily homeless’ families in England, this paper applies a utility-maximising conceptual framework to demonstrate that (a) the statutory homelessness system is on the whole ‘fair’ with respect to the housing needs that it addresses, and (b) ‘effective’, in that it can bring about significant net gains in the welfare of those households its assists. These encouraging findings are relevant not only to current concerns about the future direction of homelessness policy in England, but also to policy debates in many countries across the developed world where there are calls to develop a ‘rights-based’ approach to addressing homelessness.
Palbociclib (PD0332991)-a Selective and Potent Cyclin-Dependent Kinase Inhibitor: A Review of Pharmacodynamics and Clinical Development.

IMPORTANCE Palbociclib (PD0332991) is a newly developed drug that received breakthrough designation and recent US Food and Drug Administration approval in combination with endocrine therapy in the treatment of hormone receptor positive, ERBB2-negative (formerly HER2 or HER2/neu) breast cancer in the first-line metastatic setting. OBJECTIVE Herein we describe the preclinical and translational data and early- and late-phase clinical trials in which palbociclib has been investigated in a broad array of tumor types. We discuss the pharmacodynamics, pharmacokinetics, toxic effects, and clinical response rates. EVIDENCE REVIEW On March 1, 2015, we conducted a review of the literature describing the development of palbociclib. We used the PubMed search terms "PD0332991," "palbociclib," and "CDK4/6 inhibitor" to find all published articles of interest, without limitation as to publication date. FINDINGS Palbociclib is a potent and specific oral cyclin-dependent kinase (CDK) 4/6 inhibitor that has strong preclinical data to support its activity in retinoblastoma protein-expressing tumors. Phase 1 trials have demonstrated safety, and phase 2 trials have shown single-agent activity in mantle-cell lymphoma, breast cancer, liposarcoma, and teratoma with reversible neutropenia as the main toxic effect. Addition of palbociclib to endocrine therapy improves progression-free survival in endocrine therapy-naïve and endocrine therapy-resistant metastatic settings. CONCLUSIONS AND RELEVANCE Palbociclib is well tolerated and has therapeutic potential for multiple cancers, including breast cancer, where its efficacy has been demonstrated alone and in combination with endocrine therapy. Additional combinations of palbociclib with endocrine therapy, chemotherapy, and targeted therapy have potential in various tumors, and phase 3 trials are under way.
Adult psychosocial outcome of prepubertal major depressive disorder.

OBJECTIVE To compare adult psychosocial functioning (PSF) of subjects with prepubertal major depressive disorder (PMDD) to a normal comparison (NC) group. METHOD PSF of subjects with PMDD (n = 72) and of NC subjects (n = 28) was compared after prospective follow-up to adulthood. These 100 subjects were 90.9% of the baseline 110 subjects who participated in the "Nortriptyline in Childhood Depression: Follow-up Study. " Research nurses who were blind to group status conducted telephone interviews using the Longitudinal Interval Follow-up Evaluation (LIFE) to obtain PSF data. RESULTS At follow-up, the PMDD group was 20.7+/-2.0 and the NC subjects were 20.9+/-2.2 years old. The PMDD subjects were 10.3+/-1.5 years old at baseline. Time between baseline and follow-up was 9.9+/-1.5 years. In the PMDD group, subjects with MDD, bipolar disorder, or substance use disorders during the previous 5 years had significantly worse PSF than NC subjects. These PSF impairments included significantly worse relationships with parents, siblings, and friends; significantly worse functioning in household, school, and work settings; and worse overall quality of life and global social adjustment. CONCLUSIONS Although combined treatments for PMDD have little scientific basis, multimodality regimens seem prudent until definitive treatment data become available.
Using Teacher Instructional Leadership as a Predictor of Principal Leadership

Untold numbers of professional educators hold administrative certificates or licenses but do not use them, never taking formal administrative roles in schools. Why do so many of the graduates of our principal-preparation programs forego taking school-leadership positions and simply stick with teaching or assume other, nonadministrative-leadership positions in schools? Is the time and effort spent preparing potential administrators with such small success and great cost worth it? Informal discussions with those who pursue formal leadership positions—and with some who do not—suggest that some graduates who start their program with school-leadership experience were more likely to seek and accept formal leadership obligations. To examine this anecdotal evidence more rigorously, we undertook a three-university analysis of past graduates’ preprogram school-leadership activities. Through exploratory, secondary analyses of existing data at three institutions as well as postprogram-position information, we generally found that program participants who (1) expressed commitment to becoming formal leaders, (2) had already held responsible leadership roles in their schools working with adults, or (3) had earned an advanced degree before entering a preparation program were more likely to take administrative posts. These tentative findings have implications for the recruitment and selection of participants for principal-preparation programs, potential for raising the quality of these programs, and possibilities for decreasing costs while increasing benefits of preparation programs.
Quality of Management and Quality of Stakeholder Relations

This article presents an integrative conceptual framework for linking corporate social performance, stakeholders, and quality of management, then tests this framework empirically. Results provide strong support for the hypothesis that perceived quality of management can be explained by the quality of performance with respect to specific primary stakeholders: owners, employees, customers, and (marginally) communities, but treatment of ecological environmental considera- tions is not a significant factor.
Euro membership and fiscal reaction functions

The paper uses fiscal reaction functions for a panel of euro-area countries. We investigate whether euro membership has reduced the responsiveness to shocks in the level of inherited debt. Compared with the performance in the period between signing of the Maastricht Treaty and introduction of the euro, membership has significantly reduced the average responsiveness. Conversely, when compared to the period before the Maastricht Treaty, euro membership is associated with a larger responsiveness. The results are sensitive to changes in the specification, such as an exclusion of Greece from the panel.
Nurturing Future Generations: Household Food Practices of Canadian Children and Family Meal Participation.

PURPOSE Food knowledge and skills appear to have declined in the general population over recent decades and may be contributing to negative outcomes and poor nutritional health. It is pertinent to observe the food skills and habits of Canadians, particularly Canadian youth. METHODS Data from the Canadian Community Health Survey 2013 Rapid Response on Food Skills (n = 10 098) were used to examine the involvement of children in food preparation processes by identifying and describing the role of children in meal preparation as well as the practice of family meals. Variables were examined to assess differentiations between socio-demographic groupings (marital status, education, and income). RESULTS Results indicate a moderate to high level of child participation in Canadian household food-related activities, with two-thirds of households with children having children involved in choosing meals and grocery shopping and one-third of children helping with meal preparation. Some differences were observed between region, education level, and Aboriginal and immigration status. Seventy-five percent of respondents participated in family meals. CONCLUSIONS Data from this study contribute to the current discussion regarding loss of food skills and the significance of family meals on social and health indicators. Results suggest a range of interventions for dietitians including improving the quality of foods prepared at home and campaigns to promote family meals.
Effects of an evidence-based computerized virtual clinician on low-density lipoprotein and non-high-density lipoprotein cholesterol in adults without cardiovascular disease: The Interactive Cholesterol Advisory Tool

There is a lack of research on the use of electronic tools that guide patients toward reducing their cardiovascular disease risk. We conducted a 9-month clinical trial in which participants who were at low (n = 100) and moderate (n = 23) cardiovascular disease risk—based on the National Cholesterol Education Program III’s 10-year risk estimator—were randomized to usual care or to usual care plus use of an Interactive Cholesterol Advisory Tool during the first 8 weeks of the study. In the moderate-risk category, an interaction between treatment condition and Framingham risk estimate on low-density lipoprotein and non-high-density lipoprotein cholesterol was observed, such that participants in the virtual clinician treatment condition had a larger reduction in low-density lipoprotein and non-high-density lipoprotein cholesterol as their Framingham risk estimate increased. Perceptions of the Interactive Cholesterol Advisory Tool were positive. Evidence-based information about cardiovascular disease risk and its management was accessible to participants without major technical challenges.
Antileukotriene Therapy for the Relief of Sinus Symptoms in Aspirin Triad Disease

We studied the effect of antileukotriene therapy for the relief of sinus symptoms in patients with aspirin triad disease (ATD). We reviewed the charts of 18 ATD patients who had received antileukotriene therapy. All patients had undergone previous sinus surgery. We then designed a questionnaire to determine the level of each patient's symptoms of chronic rhino sinusitis before and after antileukotriene therapy. Responses were converted to symptom scores. For each patient, the role of therapy in the relief of sinus symptoms was evaluated in three ways: by total symptom scores, by self-reports of overall benefit, and by findings on endoscopic nasal examination. Fifteen of the 18 patients completed the questionnaire. Symptom scores for both major and minor symptoms indicated that nine patients had improved following antileukotriene therapy; three other patients reported some overall benefit from therapy, despite no improvement in their symptom scores. Endoscopic nasal examination findings were consistent with the reports of overall benefit. We conclude that antileukotriene therapy is an effective treatment for most patients whose symptoms of chronic rhino sinusitis persist following sinus surgery.
Three essays in applied economics

This thesis consists of three chapters that fall under the broad banner of applied microeconomics. The first chapter analyses the role of the 2008 amendment to the USA Lacey Act in combatting international trade in illegal timber. Comparing US timber imports over time and across countries and products, I show that the US timber imports fell after the introduction of the Lacey Act. I find the fall in timber imports is accompanied by a fall in illegal trade as measured by the difference between importer and exporter reported statistics. Finally, using the case of Indonesia, I provide suggestive evidence in favor of a reduction in deforestation as a result of the policy. The second chapter analyzes the effect of a year long rolling blackout in Colombia on mothers’ short and long run fertility behavior and socioeconomic outcomes. We use an extensive period of power rationing in Colombia throughout 1992 as a natural experiment and exploit exogenous spatial variation in the intensity of power rationing as an instrumental variable. We show that power rationing induced a “mini baby boom” nine months later. In particular, it increased the probability that a mother had a baby by five percent. Women who were exposed to the shock and had an additional child find themselves in worse socio-economic conditions more than a decade later. The third chapter documents the way in which the types of people who are admired has changed, arguing that the responses to this question tells us something about the way in which society has been evolving - the 65 years of data are probably the longest consistent series on social attitudes. We present robust correlations between admiration and trust, allowing us to provide information on trends in trust on a consistent basis back to the late 1940s, earlier than most other data sources.
Transcription Factor Expression Patterns in Bovine In Vitro-Derived Embryos Priorto Maternal-Zygotic Transition1

Abstract Maternal-zygotic transition (MZT) is a complex phenomenon characterized by the initiation of transcription in the embryo and the replacement of maternal mRNA with embryonic mRNA. In order for this to occur, transcriptional activation requires various factors and conditions. Our hypothesis is that the lack of transcription in the bovine pre-MZT embryo is due, in part, to an incomplete or dormant transcriptional apparatus. Therefore, in accordance with this hypothesis, functioning transcriptional mechanisms should appear in the eight-cell bovine embryo to facilitate embryonic transcription during the MZT. With this in mind, we examined the presence of selected transcription factors during preimplantation embryo development to establish how their transcript levels change in bovine pre-MZT embryos. To achieve this goal, real-time reverse transcription-polymerase chain reaction was used to quantify the mRNA level of several different transcription factors (YY1, HMGA1, RY-1, P300, CREB, YAP65, HMGN1, HMGB1, NFAR, OCT-4, TEAD2, ATF-1, HMGN2, MSY2, and TBP) in germinal vesicle (GV) and metaphase II (MII) bovine oocytes and in two-, four-, eight-cell, and blastocyst stage embryos produced in vitro. Our results demonstrate that all genes examined can be grouped into five different categories according to their mRNA expression patterns at the developmental stages observed. To summarize, all transcription factors studied were present in pre-MZT embryos and the expression pattern of many of them suggest a potential role in MZT.
Bipartite Ranking: a Risk-Theoretic Perspective

We present a systematic study of the bipartite ranking problem, with the aim of explicating its connections to the class-probability estimation problem. Our study focuses on the properties of the statistical risk for bipartite ranking with general losses, which is closely related to a generalised notion of the area under the ROC curve: we establish alternate representations of this risk, relate the Bayes-optimal risk to a class of probability divergences, and characterise the set of Bayes-optimal scorers for the risk. We further study properties of a generalised class of bipartite risks, based on the p-norm push of Rudin (2009). Our analysis is based on the rich framework of proper losses, which are the central tool in the study of class-probability estimation. We show how this analytic tool makes transparent the generalisations of several existing results, such as the equivalence of the minimisers for four seemingly disparate risks from bipartite ranking and class-probability estimation. A novel practical implication of our analysis is the design of new families of losses for scenarios where accuracy at the head of ranked list is paramount, with comparable empirical performance to the p-norm push.
The blind spots of trade impact assessment: macroeconomic adjustment costs and the social costs of regulatory change

Economic studies on trade liberalization typically highlight positive expected effects. This paper discusses those issues which are frequently neglected, but are nevertheless important for policy-makers. These are macroeconomic adjustment costs and social costs of regulatory change. Our discussion uses the most relevant studies on the economic effects of the Transatlantic Trade and Investment Partnership (TTIP) as reference points. We provide a rough estimate of macroeconomic adjustment costs of TTIP in the order of â‚¬33â€“60 billion over a 10-year transition period. Our analysis of regulatory change concludes that assessments have been biased and that the social costs of regulatory change due to TTIP might be substantial. Given the prominence of regulatory issues on the trade agenda, we call for full ex-ante regulatory impact assessment of future trade agreements.
Blocking the R‐type (Cav2.3) Ca2+ channel enhanced morphine analgesia and reduced morphine tolerance

Morphine is the drug of choice to treat intractable pain, although prolonged administration often causes undesirable side‐effects including analgesic tolerance. It is speculated that voltage‐dependent Ca2+ channels (VDCCs) play a key role in morphine analgesia and tolerance. To examine the subtype specificity of VDCCs in these processes, we analysed mice lacking N‐type (Cav2.2) or R‐type (Cav2.3) VDCCs. Systemic morphine administration or exposure to warm water swim‐stress, known to induce endogenous opioid release, resulted in greater analgesia in Cav2.3−/− mice than in controls. Moreover, Cav2.3−/− mice showed resistance to morphine tolerance. In contrast, Cav2.2−/− mice showed similar levels of analgesia and tolerance to control mice. Intracerebroventricular (i.c.v.) but not intrathecal (i.t.) administration of morphine reproduced the result of systemic morphine in Cav2.3−/− mice. Furthermore, i.c. v. administration of an R‐type channel blocker potentiated morphine analgesia in wild‐type mice. Thus, the inhibition of R‐type Ca2+ current could lead to high‐efficiency opioid therapy without tolerance.
Personal internet usage at work : A source of recovery

Despite enormous productivity increases during recent decades, it has been claimed that workers’ engagement in non-work-related activities severely damages companies’ productivity development. Currently, personal Internet usage seems to be the most upsetting of these activities. There is a widespread notion among management-friendly researchers, employers, and the media that all non-work-related activities are deviant and should be defeated at all costs. This conceptual article gives an overview of the organisational behaviour literature dealing with non-work-related activities at work. The prohibitive approach is both inconsistent and in practice unenforceable. This is especially true since an increasing proportion of today’s private Internet usage at work is carried out by employees using their private smartphones, a fact that has not been considered in previous research. This article contrasts theories and ideas that private Internet usage at work is deviant with theoretical overviews arguing that non-work-related activities are an expression of normal action and behaviour, which can be explained with the help of both work-life balance theory and theories on resistance. An additional concept is recovery, which has not previously been used in the debate on Internet usage. Today’s workplaces are populated by engaged employees who work at a fast pace and need recovery, well-deserved micro-pauses, and breaks from demanding work. Furthermore, some Internet surfing is actually a consequence of organisations’ inability to come up with decent work tasks to fill the whole day. The aim of this article is to point out the recovery functions of personal Internet usage in today’s working life, primarily in terms of employees’ well-being and dignity. This article contributes to the debate by proposing eight situations in which the employee should be allowed to “cyberloaf” without being disciplined. The article also suggests empirical investigations that may be carried out with regard to the views and effects of personal Internet use at work in four different settings, that is, where employees’ private Internet usage is officially forbidden, seemingly forbidden, allowed, or encouraged.
Quality of the Development of Traumatic Brain Injury Clinical Practice Guidelines: A Systematic Review

Traumatic brain injury (TBI) is a leading cause of death worldwide and is increasing exponentially particularly in low and middle income countries (LMIC). To inform the development of a standard Clinical Practice Guideline (CPG) for the acute management of TBI that can be implemented specifically for limited resource settings, we conducted a systematic review to identify and assess the quality of all currently available CPGs on acute TBI using the AGREE II instrument. In accordance with PRISMA guidelines, from April 2013 to December 2015 we searched MEDLINE, EMBASE, Google Scholar and the Duke University Medical Center Library Guidelines for peer-reviewed published Clinical Practice Guidelines on the acute management of TBI (less than 24 hours), for any level of traumatic brain injury in both high and low income settings. A comprehensive reference and citation analysis was performed. CPGs found were assessed using the AGREE II instrument by five independent reviewers and scores were aggregated and reported in percentage of total possible score. An initial 2742 articles were evaluated with an additional 98 articles from the citation and reference analysis, yielding 273 full texts examined. A total of 24 final CPGs were included, of which 23 were from high income countries (HIC) and 1 from LMIC. Based on the AGREE II instrument, the best score on overall assessment was 100.0 for the CPG from the National Institute for Health and Clinical Excellence (NIHCE, 2007), followed by the New Zealand Guidelines Group (NZ, 2006) and the National Clinical Guideline (SIGN, 2009) both with a score of 96.7. The CPG from a LMIC had lower scores than CPGs from higher income settings. Our study identified and evaluated 24 CPGs with the highest scores in clarity and presentation, scope and purpose, and rigor of development. Most of these CPGs were developed in HICs, with limited applicability or utility for resource limited settings. Stakeholder involvement, Applicability, and Editorial independence remain weak and insufficiently described specifically with piloting, addressing potential costs and implementation barriers, and auditing for quality improvement.
High‐resolution cerebral blood volume imaging in humans using the blood pool contrast agent ferumoxytol

Cerebral blood volume maps are usually acquired using dynamic susceptibility contrast imaging which inherently limits the spatial resolution and signal to noise ratio of the images. In this study, we used ferumoxytol (AMAG Pharmaceuticals, Inc., Cambridge, MA), an FDA‐approved compound, to obtain high‐resolution cerebral blood volume maps with a steady‐state approach in seven healthy volunteers. R2* maps (0.8 × 0.8 × 1 mm3) were acquired before and after injection of ferumoxytol and an intraindividual normalization protocol was used to obtain quantitative values. The results show excellent contrast between white and gray matter as well as fine highly detailed vascular structures. An average blood volume of 4% was found in the brain of all volunteers, consistent with prior literature values. A linear relationship was found between ferumoxytol dose (mg/kg) and ΔR2* (1/s) in gray (R2 = 0.98) and white matter (R2 = 0.98). A quadratic relationship was found in the sagittal sinus (R2 = 0.98). The cerebral blood volume maps compare well with lower resolution dynamic susceptibility contrast‐MRI and their use should improve the evaluation of small and heterogeneous lesions and facilitate intrapatient and interpatient comparisons. Magn Reson Med 70:705–710, 2013. © 2012 Wiley Periodicals, Inc.