Miracle-dz/UniFAR-FTUs huggingface dataset:
Revised Guidelines for Neonatal Screening Programmes for Primary Congenital Hypothyroidism

Since the first guidelines for neonatal screening for congenital hypothyroidism (CH) were issued by ESPE in 1993 [1], there have been considerable advances in our understanding of CH and our appreciation of the various geographical and logistic difficulties involved. Therefore, an updating of the guidelines is overdue. Experience from countries where screening began in the late 1970s and early 1980s has indicated that treatment should be started no later than the first 2 weeks of life using a ‘high’ dosage regime of L-thyroxine (10–15 Ìg/kg/day). It has also been shown that the quality of long-term outcome is closely related to the quality of follow-up. In Eastern Europe, screening programmes for CH have either been started or will start soon in almost all countries, and although many programmes are operating satisfactorily, it is important to standardise screening procedures and management of suspected cases as much as possible in order to optimise outcome. A degree of uniformity throughout Europe would not only facilitate early detection and treatment of individual patients but give insight into the economic and epidemiological aspects of the screening programmes as well as the epidemiological aspect of CH.
A fuzzy hybrid approach to enhance diversity in top-N recommendations

In recent researches, recommender systems performance was restricted in their ability to predict unseen items by users and recommending them those with the highest predicted ratings. To make good predictions it is not sufficient to judge the performance, because a good recommender should offer useful and diverse items that fit to different interest choices and tastes of users. Unfortunately, the lack of diversity and the stability in recommender systems over the user's profile dynamicity become a major challenge. In this paper, we propose a fuzzy hybrid diversified recommendation system able to generate multi-taste recommendations depending on the user's profile variation. Due to the fuzziness and uncertainty in user's profile, the system allows users belonging to different clusters using a fuzzy-based collaborative filtering combined with a content-based filtering algorithm. To identify the user's neighbourhood, a novel similarity measure is proposed. To increase diversity in recommended lists, subsets from Top-N recommended lists in similar clusters, are selected according to users membership degrees. Several experiments are conducted on Movilens dataset to prove the proposal's effectiveness.
From Travel Plans to Magic Wands: A Cross-Domain Study of Practices and Privacy Requirements for Sharing Emerging Types of Online Content

Online social networks have made sharing photos and other digital content a common activity. Recently, a range of novel online services and connected devices have expanded the set of “things” to share – ranging from new types of digital content like music preferences and workout data to physical things like household items (“sharing economy”). To understand user needs, concerns and preferences in such emerging sharing domains, we collected 200 responses about participants’ experiences with sharing six categories of “things”: music preferences; travel plans; sports activity; real-world items (e.g., rooms and vehicles); virtual items in online games; and dietary preferences. For each category, we systematically describe what our participants share and with whom. Additionally, we asked 56 “non-sharers” to describe their reasons to refrain from sharing personal content from these categories. Using qualitative analysis methods, we use information from both “sharers” and “non-sharers” to identify privacy concerns that frame content sharing, and we discuss how factors like audience perception and sharing controls should inform the design of newly emerging sharing services.
Development of a digital image database for chest radiographs with and without a lung nodule: receiver operating characteristic analysis of radiologists' detection of pulmonary nodules.

OBJECTIVE We developed a digital image database (www.macnet.or.jp/jsrt2/cdrom_nodules.html ) of 247 chest radiographs with and without a lung nodule. The aim of this study was to investigate the characteristics of image databases for potential use in various digital image research projects. Radiologists' detection of solitary pulmonary nodules included in the database was evaluated using a receiver operating characteristic (ROC) analysis. MATERIALS AND METHODS One hundred and fifty-four conventional chest radiographs with a lung nodule and 93 radiographs without a nodule were selected from 14 medical centers and were digitized by a laser digitizer with a 2048 x 2048 matrix size (0.175-mm pixels) and a 12-bit gray scale. Lung nodule images were classified into five groups according to the degrees of subtlety shown. The observations of 20 participating radiologists were subjected to ROC analysis for detecting solitary pulmonary nodules. Experimental results (areas under the curve, Az) obtained from observer studies were used for characterization of five groups of lung nodules with different degrees of subtlety. RESULTS ROC analysis showed that the database included a wide range of various nodules yielding Az values from 0.574 to 0.991 for the five categories of cases for different degrees of subtlety. CONCLUSION This database can be useful for many purposes, including research, education, quality assurance, and other demonstrations.
Preventive role of erythropoietin against aminoglycoside renal toxicity induced nephropathy; current knowledge and new concepts

Implication for health policy/practice/research/medical education:Erythropoietin is a promising renoprotective drug to prevent or attenuate tubular damage induced by gentamicin or other nephrotoxic agents which act through the same mechanisms as gentamicin. In this regard, to better understand the preventive properties of erythropoietin, more experimental or clinical studies are suggested.
Recognition of the DNA sequence by an inorganic crystal surface

The sequence-dependent curvature is generally recognized as an important and biologically relevant property of DNA because it is involved in the formation and stability of association complexes with proteins. When a DNA tract, intrinsically curved for the periodical recurrence on the same strand of A-tracts phased with the B-DNA periodicity, is deposited on a flat surface, it exposes to that surface either a T- or an A-rich face. The surface of a freshly cleaved mica crystal recognizes those two faces and preferentially interacts with the former one. Statistical analysis of scanning force microscopy (SFM) images provides evidence of this recognition between an inorganic crystal surface and nanoscale structures of double-stranded DNA. This finding could open the way toward the use of the sequence-dependent adhesion to specific crystal faces for nanotechnological purposes.
Effect of tracer buoyancy on tracer experiments conducted in fractured crystalline bedrock

Tracer buoyancy has been shown to influence breakthrough from two‐well tracer experiments conducted in porous media. Two‐well tracer experiments are presented from fractured crystalline bedrock, in which the specific gravity of the tracer injectate varied from 1.0002 to 1.0133. Under the forced hydraulic conditions imposed, no difference in breakthrough was noted for the three experiments. These results show that even relatively dense tracer injectate solutions may have an insignificant effect on breakthrough when imposed gradients are sufficiently large.
A Retrospective Study of Implant–Abutment Connections on Crestal Bone Level

This study compared the effects of external hex, internal octagon, and internal Morse taper implant–abutment connections on the peri-implant bone level before and after the occlusal loading of dental implants. Periapical radiographs of 103 implants (63 patients) placed between 2002 and 2010 were collected, digitized, standardized, and classified into groups based on the type of implant–abutment connection. These radiographs were then analyzed with image-processing software to measure the peri-implant crestal bone change during the healing phase (4 months after implant placement) and at loading phases 1 and 2 (3 and 6 months after occlusal loading, respectively). A generalized estimating equation method was employed for statistical analysis. The amount of peri-implant crestal bone change differed significantly among all time–phase pairs for all 3 types of implant–abutment connection, being greater in the healing phase than in loading phase 1 or 2. However, the peri-implant crestal bone change did not differ significantly among the 3 types of implant–abutment connections during the healing phase, loading phase 1, or loading phase 2. This retrospective clinical study reveals that the design of the implant–abutment connection appears to have no significant impact on short-term peri-implant crestal bone change.
Urinary TMPRSS2:ERG and PCA3 in an Active Surveillance Cohort: Results from a Baseline Analysis in the Canary Prostate Active Surveillance Study

Purpose: Active surveillance is used to manage low-risk prostate cancer. Both PCA3 and TMPRSS2:ERG are promising biomarkers that may be associated with aggressive disease. This study examines the correlation of these biomarkers with higher cancer volume and grade determined at the time of biopsy in an active surveillance cohort. Experimental Design: Urine was collected after digital rectal examination prospectively as part of the multi-institutional Canary Prostate Active Surveillance Study (PASS). PCA3 and TMPRSS2:ERG levels were analyzed in urine collected at study entry. Biomarker scores were correlated to clinical and pathologic variables. Results: In 387 men, both PCA3 and TMPRSS2:ERG scores were significantly associated with higher volume disease. For a negative repeat biopsy, and 1% to 10%, 11% to 33%, 34% or more positive cores, median PCA3, and TMPRSS2:ERG scores increased incrementally (P < 0.005). Both PCA3 and TMPRSS2:ERG scores were also significantly associated with the presence of high-grade disease. For a negative repeat biopsy, Gleason 6 and Gleason ≥7 cancers, the median PCA3, and TMPRSS2:ERG scores also increased incrementally (P = 0.02 and P = 0.001, respectively). Using the marker scores as continuous variables, the ORs for a biopsy in which cancer was detected versus a negative repeat biopsy (ref) on modeling was 1.41 (95% CI: 1.07–1.85), P = 0.01 for PCA3 and 1.28 (95% CI: 1.10–1.49), P = 0.001 for TMPRSS2:ERG. Conclusions: For men on active surveillance, both PCA3 and TMPRSS2:ERG seem to stratify the risk of having aggressive cancer as defined by tumor volume or Gleason score. Clin Cancer Res; 19(9); 2442–50. ©2013 AACR.
SYSTEMIC AND REGIONAL HEMODYNAMIC EFFECTS OF HIGH-DOSE EPINEPHRINE INFUSION IN HYPOXIC PIGLETS RESUSCITATED WITH 100% OXYGEN

Shock and poor regional perfusion are common in asphyxiated neonates. We compared the systemic and regional hemodynamic effects of high-dose epinephrine (E) with those of dopamine combined with low-dose epinephrine (DE) infusions in a neonatal model of hypoxia-reoxygenation. Neonatal piglets (1-3 days, 1.5-2.5 kg) were acutely instrumented to continuously monitor systemic arterial pressure (SAP), pulmonary artery pressure, cardiac index (CI), and blood flows at the left common carotid, superior mesenteric, and renal arteries. Either epinephrine (1 &mgr;g · kg−1 · min−1) or dopamine (10 &mgr;g · kg−1 · min−1) and epinephrine (0.2 &mgr;g · kg−1 · min−1) were given for 2 h in hypoxic piglets resuscitated with 100% oxygen (n = 8 per group) in a randomized blinded fashion. Control piglets received hypoxia and reoxygenation but no catecholamine infusion (n = 7). Alveolar hypoxia (PaO2, 33-37 mmHg) caused reduced CI (89-92 vs. 171-186 mL · kg−1 · min−1 of baseline, P < 0.05), hypotension (SAP, 28-32 mmHg) with pH 7.05 to 7.10, and decreased regional flows. Upon reoxygenation, CI and SAP improved but gradually deteriorated to 131 to 136 mL · kg−1 · min−1 and 41 to 49 mmHg at 2 h of reoxygenation, respectively. E and DE administration similarly improved CI (167 ± 60 and 166 ± 55 vs. 121 ± 35 mL · kg−1 · min−1 of controls) and SAP (53 ± 7 and 56 ± 10 vs. 39 ± 8 mmHg of controls), respectively, and the pulmonary vascular resistance (vs. controls, all P < 0.05). Heart rate and pulmonary artery pressure were not different between groups. Systemic oxygen delivery and consumption were increased in E- and DE-treated groups with no difference in extraction ratio between groups. There were no differences in regional blood flows and oxygen delivery between groups. After hyperlactatemia with hypoxia, plasma lactate levels decreased with no difference between groups. Epinephrine given as the sole agent is as effective as dopamine and low-dose epinephrine combined in treating shock and hypotension that follow the resuscitation of hypoxic neonatal piglets, with no reduction in regional perfusion.
Coronary angioplasty reduces free wall rupture and improves mortality and morbidity of acute myocardial infarction.

BACKGROUND Free wall rupture (FWR) is one of the major causes of mortality in acute myocardial infarction (AMI). To what extent coronary angioplasty for AMI would modify the predictors of FWR is not clear. METHODS In prospective database of consecutive 3,138 AMI patients seen between May 1985 to May 2002, 3,096 patients (98.7%) who underwent emergent coronary angiography were analyzed retrospectively. The incidence of FWR was determined by univariate and multivariate analyses. RESULTS FWR after admission occurred in 40 (1.3%) patients. A higher rate of FWR was associated with: 1) not having coronary angioplasty (3.2% vs. 0.9%, p< 0.0001); 2) thrombolytic agents usage (2.4% vs. 1.0%, p = 0.004); 3) female gender (2.5% vs. 1.1%, p = 0.0004); 4) failed reperfusion (5.4% vs. 0.9%, p< 0.0001); and 5) LMT-related infarct (4.7% vs. 1.2%, p = 0.02) in univariate analysis. Five conditions were identified as significant protective or predictive factors of FWR in multivariate logistic regression analysis: having coronary angioplasty (odds ratio [OR]: 0.45, 95% confidence interval [95% CI] 0.22-0.94, p = 0.03), failed reperfusion (OR: 4.57, 95% CI: 2.31-9.05, p< 0.0001), LMT-related infarct (OR: 4.96, 95% CI: 1.42-17.34, p = 0.01), female gender (OR: 2.17, 95% CI: 1.11-4.25, p = 0.02) and age (OR: 1.04, 95% CI: 1.00-1.07, p = 0.03). Coronary angioplasty alone resulted in a lower incidence of FWR (0.5%) than thrombolysis alone (1.6%, p = 0.02), coronary angioplasty with thrombolysis (3.3%, p< 0.0001) and without either treatment (6.3%, p< 0.0001). CONCLUSIONS Angiographic reperfusion success was the most significant protective factor from FWR. Coronary angioplasty reduced FWR complicating AMI and its concomitant fatality.
Hand Rim Wheelchair Propulsion Training Using Biomechanical Real-Time Visual Feedback Based on Motor Learning Theory Principles

Abstract Background/Objective: As considerable progress has been made in laboratory-based assessment of manual wheelchair propulsion biomechanics, the necessity to translate this knowledge into new clinical tools and treatment programs becomes imperative. The objective of this study was to describe the development of a manual wheelchair propulsion training program aimed to promote the development of an efficient propulsion technique among long-term manual wheelchair users. Methods: Motor learning theory principles were applied to the design of biomechanical feedback-based learning software, which allows for random discontinuous real-time visual presentation of key spatiotemporal and kinetic parameters. This software was used to train a long-term wheelchair user on a dynamometer during 3 low-intensity wheelchair propulsion training sessions over a 3-week period. Biomechanical measures were recorded with a SmartWheel during over ground propulsion on a 50-m level tile surface at baseline and 3 months after baseline. Results: Training software was refined and administered to a participant who was able to improve his propulsion technique by increasing contact angle while simultaneously reducing stroke cadence, mean resultant force, peak and mean moment out of plane, and peak rate of rise of force applied to the pushrim after training. Conclusions: The proposed propulsion training protocol may lead to favorable changes in manual wheelchair propulsion technique. These changes could limit or prevent upper limb injuries among manual wheelchair users. In addition, many of the motor learning theory—based techniques examined in this study could be applied to training individuals in various stages of rehabilitation to optimize propulsion early on.
Characterization and evaluation of microsatellite markers in a strain of the oriental fruit fly, Bactrocera dorsalis (Diptera: Tephritidae), with a genetic sexing character used in sterile insect population control

The oriental fruit fly, Bactrocera dorsalis, is a key economic insect pest reducing fruit yield and generating constraints in the international market. The application of the sterile insect technique (SIT) continues to reveal areas where new technologies can improve the effectiveness of fruit fly control. One such advancement concerns insect strains. In the present study, a mass-reared strain of the fly with a translocation-based genetic sexing character (Salaya1) based on a brown-white pupal colour dimorphism was genetically characterized using 11 microsatellite DNA markers. Subsequently, these markers were used to evaluate the maintenance of genetic variability in the strain under mass-rearing conditions. Mating competitiveness of this strain was also tested in field cages. Two of the newly characterized Y-pseudo-linked microsatellite markers were used for strain identification in field monitoring traps. The strain was also validated in a pilot integrated pest management (IPM) programme using male-only SIT in a fruit orchard. The programme resulted in the suppression of the fruit fly population.
[Intestinal flukes of genus Metagonimus and their second intermediate hosts in Kangwon-do].

This study investigate the epidemiological feature of Metagonimus infection in Kangwon-do (province). The average infection rate of the surveyed inhabitants was 7.8% (83 positives out of 1, 067 examinees) by stool examination; male, 11.4% and female, 3.2%, respectively. The egg positive rate in residents in the Som river area was 7.3%, that of the Chuchon river area 6.3%, the Pyongchang river area 12.8%, the Tong river area 3.8%, the Hongchon river area 9.8%, and the Ohsip stream area of Samchok 8.0%, respectively. The average metacercarial infection rate of genus Metagonimus in the fish was 81.0% (256 positives out of 318 fish). The infected fishes were Zacco platypus, Zacco temmincki, Opsariichthys bidens, Squalidis sp. , Carassius carassius, etc. in western Kangwon-do Meanwhile, in the Ohsip stream area of Samchok-gun, eastern costal Kangwon-do, the infected fish were Plecoglossus altivelis and Tribolodon hakonensis. The rats and dogs are infected with the metcercariae obtained from Zacco platypus and Opsariichthys bidens, adult worms collected were Miyata type of Metagonimus with some M. takahashii. When infected with metacercariae from Plecoglossus altivelis, Metagonimus yokogawai was only found. M. yokogawai and Metagonimus Miyata type were found together in Tribolodon hakonensis in Ohsip stream area of Samchok, in the eastern Kangwon-do. The intestinal flukes of genus Metagonimus in western Kangwon-do were Miyata type of Metagonimus and M. takahashii, transmitting mainly by Zacco platypus and Opsariichthys bidens as a source of infection. In the eastern part of Kangwon province (Ohsip stream area of Samchok), M. yokogawai was mainly distributed by P. altivelis and T. hakonesis, but some T. hakonensis harbored the metacercariae of Miyata type of Metagonimus with those of M. yokogawai.
The Induction of Mood States and Their Effect on Cognitive and Social Behaviors

or the &dquo;glow of good will. &dquo; Aderman (1972) studied the relationship between affect and helping behavior by using self-referent mood statements developed by Velten (1968) to induce affect states, and then measuring helping behavior. Strickland et al., using the same mood statements to induce affect states, found that subjects in the positive affect group reported themselves to be significantly less depressed, less anxious, less hostile, more likely to wish to engage in social, active endeavors, and to be more expansive in graphic expression than subjects in the negative affect group. The present study attempted to replicate some of the findings of Aderman and Strickland _et _al. and to investigate other cognitive and social behaviors which are reportedly affected by mood. Subjects read either elation, depression, or neutral statements and then were administered eight behavioral, cognitive, and social measures. It was predicted that subjects in the depression condition would perform more poorly on cognitive tasks, report a more depressed mood, experience time as passing
Weighted Country Product Dummy Variable Regressions and Index Number Formulae

The article considers a very simple type of hedonic regression model where the only characteristic of a commodity is the commodity itself. This regression model is known as the country product dummy method for calculating country price parities in the context of making international comparisons. The paper considers only the two country or two period case and introduces value or quantity weights into the regression. The resulting measures of overall price change between the two countries or time periods are compared to traditional bilateral index number formulae. It is shown how the Geary Khamis, Walsh and Tornqvist price indexes can be obtained as special cases of this framework.
Proteogenomic analysis and global discovery of posttranslational modifications in prokaryotes

Significance Proteogenomics is the application of mass spectrometry-derived proteomic data for testing and refining predicted genetic models. Cyanobacteria, the only prokaryotes capable of oxygenic photosynthesis, are the ancestor of chloroplasts in plants and play crucial roles in global carbon and nitrogen cycles. An integrated proteogenomic workflow was developed, and we tested this system on a model cyanobacterium, Synechococcus 7002, grown under various conditions. We obtained a nearly complete genome translational profile of this model organism. In addition, a holistic view of posttranslational modification (PTM) events is provided using the same dataset, and the results provide insights into photosynthesis. The entire proteogenomics pipeline is applicable to any sequenced prokaryotes and could be applied as a standard part of genome annotation projects. We describe an integrated workflow for proteogenomic analysis and global profiling of posttranslational modifications (PTMs) in prokaryotes and use the model cyanobacterium Synechococcus sp. PCC 7002 (hereafter Synechococcus 7002) as a test case. We found more than 20 different kinds of PTMs, and a holistic view of PTM events in this organism grown under different conditions was obtained without specific enrichment strategies. Among 3,186 predicted protein-coding genes, 2,938 gene products (>92%) were identified. We also identified 118 previously unidentified proteins and corrected 38 predicted gene-coding regions in the Synechococcus 7002 genome. This systematic analysis not only provides comprehensive information on protein profiles and the diversity of PTMs in Synechococcus 7002 but also provides some insights into photosynthetic pathways in cyanobacteria. The entire proteogenomics pipeline is applicable to any sequenced prokaryotic organism, and we suggest that it should become a standard part of genome annotation projects.