Miracle-dz/UniFAR-FTUs huggingface dataset:
Functional characterization of the rod visual pigment of the echidna (Tachyglossus aculeatus), a basal mammal

Abstract Monotremes are the most basal egg-laying mammals comprised of two extant genera, which are largely nocturnal. Visual pigments, the first step in the sensory transduction cascade in photoreceptors of the eye, have been examined in a variety of vertebrates, but little work has been done to study the rhodopsin of monotremes. We isolated the rhodopsin gene of the nocturnal short-beaked echidna (Tachyglossus aculeatus) and expressed and functionally characterized the protein in vitro. Three mutants were also expressed and characterized: N83D, an important site for spectral tuning and metarhodopsin kinetics, and two sites with amino acids unique to the echidna (T158A and F169A). The λmax of echidna rhodopsin (497.9 ± 1.1 nm) did not vary significantly in either T158A (498.0 ± 1.3 nm) or F169A (499.4 ± 0.1 nm) but was redshifted in N83D (503.8 ± 1.5 nm). Unlike other mammalian rhodopsins, echidna rhodopsin did react when exposed to hydroxylamine, although not as fast as cone opsins. The retinal release rate of light-activated echidna rhodopsin, as measured by fluorescence spectroscopy, had a half-life of 9.5 ± 2.6 min−1, which is significantly shorter than that of bovine rhodopsin. The half-life of the N83D mutant was 5.1 ± 0.1 min−1, even shorter than wild type. Our results show that with respect to hydroxylamine sensitivity and retinal release, the wild-type echidna rhodopsin displays major differences to all previously characterized mammalian rhodopsins and appears more similar to other nonmammalian vertebrate rhodopsins such as chicken and anole. However, our N83D mutagenesis results suggest that this site may mediate adaptation in the echidna to dim light environments, possibly via increased stability of light-activated intermediates. This study is the first characterization of a rhodopsin from a most basal mammal and indicates that there might be more functional variation in mammalian rhodopsins than previously assumed.
Comparison of Neuropsychological and FDG-PET Findings between Early- versus Late-Onset Mild Cognitive Impairment: A Five-Year Longitudinal Study

Aims: Our purpose was to investigate differences in neuropsychological characteristics and glucose metabolism between early-onset mild cognitive impairment (EOMCI) and late onset MCI (LOMCI) patients and to determine if the baseline differences are predictive of conversion to dementia. Methods: We enrolled 28 patients with MCI (12 EOMCI, 16 LOMCI) and 2 age-matched control groups. At the end of a 5-year follow-up, we compared the baseline neuropsychological and PET data between converters and nonconverters. Results: The EOMCI patients obtained significantly higher scores in verbal recall and word fluency tests than the LOMCI patients. The EOMCI group, compared to the young controls, demonstrated hypometabolism in brain regions vulnerable in mild Alzheimer’s disease. Converters were significantly more impaired in the delayed verbal recall test than nonconverters (p = 0.028) and tended to be more impaired in the semantic word fluency test (p = 0.084). The baseline PET scan of the converters demonstrated severer hypometabolism in frontal areas than that of the nonconverters both in the EOMCI and LOMCI groups. Conclusion: Our study suggests that EOMCI patients may differ from LOMCI in the patterns of cognitive deficits and glucose hypometabolism. In addition, baseline neuropsychological and FDG-PET findings suggest that MCI patients with poor memory or frontal dysfunction are at greater risk of conversion to dementia.
A Novel Mitochondrial Carnitine-acylcarnitine Translocase Induced by Partial Hepatectomy and Fasting*

The carnitine-dependent transport of long-chain fatty acids is essential for fatty acid catabolism. In this system, the fatty acid moiety of acyl-CoA is transferred enzymatically to carnitine, and the resultant product, acylcarnitine, is imported into the mitochondrial matrix through a transporter named carnitine-acylcarnitine translocase (CACT). Here we report a novel mammalian protein homologous to CACT. The protein, designated as CACL (CACT-like), is localized to the mitochondria and has palmitoylcarnitine transporting activity. The tissue distribution of CACL is similar to that of CACT; both are expressed at a higher level in tissues using fatty acids as fuels, except in the brain, where only CACL is expressed. In addition, CACL is induced by partial hepatectomy or fasting. Thus, CACL may play an important role cooperatively with its homologue CACT in a stress-induced change of lipid metabolism, and may be specialized for the metabolism of a distinct class of fatty acids involved in brain function.
The Role of High-Tech Capital Formation for Swedish Productivity Growth*

While using new data and standard growth-accounting techniques, this paper takes a closer look at the Swedish productivity revival in the second half of the 1990s. In particular, I find large total factor productivity growth in high-tech producing sectors and capital deepening associated with high-tech equipment elsewhere. In addition, for high-tech producers, high-tech capital deepening has as a rule contributed negatively to labor productivity growth - a result above all driven by large increases in hours worked in this sector. I also find that in the business sector, the contribution from high-tech capital deepening to labor productivity growth increased from about 1 percent 1994 to 9 percent 1999.
A typology of governance and its implications for tourism policy analysis

Governance is a key concept in politics and public policy that is increasingly utilised in tourism. Using the notion of “policy as theory”, a typology of governance suitable for tourism is systematically developed. Categorical variables are developed from the relationship between state intervention and self-regulation and the relationships between policy actors and steering modes. The resultant matrix identifies four governance types: hierarchies, markets, networks and communities. A 12-point framework of governance identifies core elements, including classifying characteristics, policy themes, policy standpoints, democratic models, primary focus, views of non-central actors, distinctions between policymaking and implementation, success criteria, implementation gaps, the reasons and solutions for those gaps and the primary policy instruments used. An example of the application is provided using an analysis of state party's implementation of the 1993 Convention on Biological Diversity. It is concluded that clear categorical variables contribute to improved formulation and evaluation of explanatory claims, help clarify key concepts and assist in the comparative analysis of governance and tourism policy between jurisdictions and over time.
Challenges of the Informal Economy for the Field of Management

Executive Overview The informal economy comprises business activities that are unregistered and unregulated but not otherwise illegal (Hart, 2006). Studying informal activity yields important insights for mainstream theories of management, pointing to areas for new theorizing on the boundaries of the firm, diversification, dynamic capabilities, absorptive capacity, property rights, governance, stakeholder theory, disruptive technology, innovation, and organizational legitimacy. I argue that research on this sector is not only an opportunity for management scholars but also essential to the continued relevance and vitality of management as a discipline.
Exercise training and heart rate variability in older adult female subjects.

INTRODUCTION Prior investigations in post-myocardial infarction and healthy elderly subjects have established that heart rate variability (HRV) predicts mortality. Predominantly cross-sectional studies have shown an association between endurance training and measures of HRV. In a randomized trial, this study sought to prospectively compare the effects of endurance and strength training on HRV in 45 healthy elderly females (average age 69.9 +/- 0.9 years). METHODS All subjects were rigorously screened to be normal by history, physical, blood tests, ECG, ETT and echocardiogram. All subjects were monitored for 24 hours by a 2-channel Holter before and after training. Artifacts and arrhythmias were manually removed. Tapes were examined for standard measures of HRV. INTERVENTION 15 subjects were randomized to endurance trained (ET), 15 subjects to strength training (ST), and 15 subjects to no training (NT) for six months. RESULTS Training resulted in a significant increase in VO2max in the ET (+7.4%, p = 0.005) group only. There was a small but not significant decrease in HR with both the ET and ST groups. ET resulted in a significant increase in most time domain and all frequency domain measures of HRV. ST resulted in no significant change in HRV measures. CONCLUSION Strength training, as opposed to endurance training has no significant impact on HRV. This suggests that exercise interventions designed to improve strength (such as weight-lifting) will have little to no impact on HRV, suggesting that aerobic and strength training operate through different mechanisms to reduce cardiac risk.
Does the Euro affect the dynamic interactions of stock markets in Europe? Evidence from France, Germany and Italy

The dynamic links between stock market indices are analyzed in a GARCH-M framework, using daily data from France, Germany, Italy and the USA. It is shown that indices in the periods before and after the introduction of the Euro as a single currency display a very distinct behaviour. Consistent with the literature, in the earlier period price changes are found to have an impact the next day on other markets. In the latter period this type of co-movement disappeared within Europe. Feedback trading has been shown to induce (negative) autocorrelation in national stock markets. In this paper an international version of the feedback trading model is used to illustrate that the lead–lag relationships across countries and the strength of these links depend on the currency regime.
Speed of Issuance, Lender Specialization, and the Rise of the 144A Debt Market

Using a large sample of convertible and straight debt issues in the public, 144A, and bank loan markets from 1991 to 2004, we find that the 144A market has risen largely at the expense of the nonshelf public market, the overwhelming majority of the 144A issues are subsequently registered, and straight debt issuers with the highest credit quality and transparency tend to use the shelf public market. Our findings suggest that firms’ preference for speed of issuance drives the growth of the 144A market, and banks and qualified institutional buyers have advantages over public lenders in handling credit risk and information asymmetry.
Home Care Before and After Hospitalization for an Acute Myocardial Infarction in Alberta, Canada

ABSTRACT Home care services are provided to about 10% of those admitted to hospital for acute myocardial infarction and about 20% of those discharged from hospital. The use of home care in patients with an acute myocardial infarction is growing in Alberta over the brief time span of this four year study. Those that received home care prior to a hospitalization for acute myocardial infarction were “old and frail” with a high mortality rate during and after hospitalization. The provision of home care after hospitalization selected those patients that stay in hospital longer and required more hospital care. Background: The use of home care before and after hospitalization for acute myocardial infarction is described. Methods: Hospital discharge abstracts were used to identify patients hospitalized in Alberta, Canada for acute myocardial infarction which were then linked to home care administrative data. Results: There were 12,648 patients with acute myocardial infarction from April 1, 1995 until March 31, 1999. Home care within 60 days prior to hospitalization was provided for 8.7% of patients with acute myocardial infarctions (n = 1097) which significantly (p = 0.023) increased from 7.6% in the fiscal year 1995/6 to 9.5% in the fiscal year 1998/9. Home care within 60 days after hospitalization was provided to 16.4% of patients with acute myocardial infarctions (n = 2076) which significantly (p < 0.000) increased from 14.1% in the fiscal year 1995/6 to 18.1% in fiscal year 1998/9. Recipients of home care were significantly older, had more comorbidities, and greater severity of illness, but were less likely to undergo coronary artery revascularization during hospitalization. After multivariate adjustment, length of hospital stay, 60 day re-admissions, and mortality were higher in those receiving home care post hospitalization. Nearly half of those receiving home care prior to hospitalization died within one year. 80% of those receiving home care prior to admission also received home care services after hospitalization. Conclusion: Those patients who received home care prior to a hospitalization for acute myocardial infarction were “old and frail” with a high mortality rate during and after hospitalization. The provision of home care after hospitalization selected those patients that stay in hospital longer and required more hospital care.
Bringing Leased Assets onto the Balance Sheet

Pending changes in lease accounting standards will require firms to recognize obligations that have historically been kept off-balance-sheet (OBS). We examine the implications of this accounting treatment for a host of common risk and performance metrics. Conventional leverage, Z-Score, levered beta, return on capital and other asset utilization measures underestimate risk and overstate performance of firms relying heavily on OBS leasing. The distortion affects relative rankings as well as average levels and has increased over time. Proposed changes in reporting standards aim to mitigate future distortion, but necessitate adjustments for time-series comparisons. Under current reporting standards, investors, analysts, and researchers can estimate leased asset value and adjust accounting-based metrics to better reflect these fixed costs.
SIP/SHIP inhibits Xenopus oocyte maturation induced by insulin and phosphatidylinositol 3-kinase

SIP (signaling inositol phosphatase) or SHIP (SH2-containing inositol phosphatase) is a recently identified SH2 domain-containing protein which has been implicated as an important signaling molecule. SIP/SHIP becomes tyrosine phosphorylated and binds the phosphotyrosine-binding domain of SHC in response to activation of hematopoietic cells. The signaling pathways and biological responses that may be regulated by SIP have not been demonstrated. SIP is a phosphatidylinositol- and inositol-polyphosphate 5-phosphatase with specificity in vitro for substrates phosphorylated at the 3' position. Phosphatidylinositol 3'-kinase (PI 3-kinase) is an enzyme which is involved in mitogenic signaling and whose phosphorylated lipid products are predicted to be substrates for SIP. We tested the hypothesis that SIP can modulate signaling by PI 3-kinase in vivo by injecting SIP cRNAs into Xenopus oocytes. SIP inhibited germinal vesicle breakdown (GVBD) induced by expression of a constitutively activated form of PI 3-kinase (p110*) and blocked GVBD induced by insulin. SIP had no effect on progesterone-induced GVBD. Catalytically inactive SIP had little effect on insulin- or PI 3-kinase-induced GVBD. Expression of SIP, but not catalytically inactive SIP, also blocked insulin-induced mitogen-activated protein kinase phosphorylation in oocytes. SIP specifically and markedly reduced the level of phosphatidylinositol (3,4,5) triphosphate [PtdIns(3,4,5)P3] generated in oocytes in response to insulin. These results demonstrate that a member of the phosphatidylinositol polyphosphate 5-phosphatase family can inhibit signaling in vivo. Further, our data suggest that the generation of PtdIns(3,4,5)P3 by PI 3-kinase is necessary for insulin-induced GVBD in Xenopus oocytes.
Extraversion and life satisfaction: A cross-cultural examination of student and nationally representative samples.

OBJECTIVE Previous research on Extraversion and life satisfaction suggests that extraverted individuals are more satisfied with their lives. However, existing studies provide inflated effect sizes, as they were based on simple correlations. In five studies, the authors provide better estimates of the relationship between Extraversion and life satisfaction. METHOD The current study examined student and nationally representative samples from Canada, the United States, the United Kingdom, Germany, and Japan (Study 1, N = 1,460; Study 2, N = 5,882; Study 3, N = 18,683; Study 4, N = 13,443; Study 5, Japan N = 952 and U.S. N = 891). The relationship between Extraversion and life satisfaction was examined using structural equation modeling by regressing life satisfaction on the Big Five traits. RESULTS Extraversion was a unique predictor of life satisfaction in the North American student and nationally representative samples (Study 1, β = .232; Study 2, β = .225; Study 5, β = .217), but the effect size was weaker or absent in other non-North American samples (Germany, United Kingdom, and Japan). CONCLUSIONS The findings attest to the moderating role of culture on Extraversion and life satisfaction and the importance of controlling for shared method variance.
UK Labour Productivity Since the Onset of the Crisis — An International and Historical Perspective

UK labour productivity has been persistently weak since the onset of the recent financial crisis. This suggests that there is significant spare capacity within UK companies, but business surveys instead point to little spare capacity. This article aims to shed light on this puzzle by looking at cross-country and historical evidence. It finds that it has been unusual to see persistently weak labour productivity after previous financial crises in advanced economies. UK labour productivity stands out as being weak relative to historic episodes; it is also weak compared to other countries in the recent crisis. This weakness is concentrated in the energy and service sectors, suggesting the supply potential of the economy has grown more slowly than usual since the start of the crisis.
Cycles in the sky: understanding and managing business cycles in the airline market

The airline market is a highly cyclical business with relatively poor returns on invested capital. The fluctuations in the market put the carriers under severe economic pressure, and most of them lack strategies for cycle oriented behavior. The focus of the research conducted at Lufthansa German Airlines is the analysis of fundamental, cycle-generating structures in the airline market and the identification of alternative strategies for effective “cycle-management”. The system dynamics approach is combined with a statistical forecasting model—a combination that proved to be valuable for the analysis and management of airline business cycles. The article describes a successful system dynamics study in a complex and fast changing environment. Insights generated during the project work are now going to influence order policies for new commercial aircraft for the carrier. Copyright © 2001 John Wiley & Sons, Ltd.
PRODUCT INNOVATION IN DURABLE GOODS MONOPOLY WITH PARTIAL PHYSICAL OBSOLESCENCE

PRODUCT INNOVATION IN DURABLE GOODS MONOPOLY WITH PARTIAL PHYSICAL OBSOLESCENCE Atil, Aysun M.A., Department of Economics Supervisors: Assist. Prof. Dr. Kevin Hasker September 2007 In the literature on planned obsolescence, it has always been assumed that the durable goods monopolist is able to limit the durability of the whole of the product. However, usually it is a component of the product rather than the whole unit that becomes physically obsolete. In this paper, we analyze R&D incentives of a durable goods monopolist when he is able to engage in partial physical obsolescence. We showed that under these circumstances competition in component goods market causes inefficient R&D decisions in the primary market.
Debt Overhangs: Past and Present

We identify the major public debt overhang episodes in the advanced economies since the early 1800s, characterized by public debt to GDP levels exceeding 90% for at least five years. Consistent with Reinhart and Rogoff (2010) and other more recent research, we find that public debt overhang episodes are associated with growth over one percent lower than during other periods. Perhaps the most striking new finding here is the duration of the average debt overhang episode. Among the 26 episodes we identify, 20 lasted more than a decade. Five of the six shorter episodes were immediately after World Wars I and II. Across all 26 cases, the average duration in years is about 23 years. The long duration belies the view that the correlation is caused mainly by debt buildups during business cycle recessions. The long duration also implies that cumulative shortfall in output from debt overhang is potentially massive. We find that growth effects are significant even in the many episodes where debtor countries were able to secure continual access to capital markets at relatively low real interest rates. That is, growth-reducing effects of high public debt are apparently not transmitted exclusively through high real interest rates.
Does Gender Affect Korean Tourists' Overseas Travel? Applying the Model of Goal-Directed Behavior

Tourism is one of the world's largest and fastest-growing industries, and female travelers continue to contribute to the growth of the industry. However, little conceptual research has been conducted on overseas travel behavior and the role of gender in the decision-making process. Thus, this study examined the sophisticated decision-making process of overseas travel and the moderating effect of gender in the decision-making process, using the model of goal-directed behavior (MGB). The results indicate that the MGB is a powerful framework for explaining overseas travel behavior and that gender plays a critical role during the decision-making process. Both theoretical and practical implications are discussed in the discussion section.
Inflation Protection from Homeownership: Long‐Run Evidence, 1814–2008

type="main"> This article examines the inflation hedging capacity of the private home. We employ unique long-term data for inflation, house price dynamics and rents for Amsterdam dating back to 1814, allowing us to study total housing returns in different inflation regimes and for varying investment horizons. Our Amsterdam data show that homeownership's protection against actual and expected inflation increases with the investment horizon. This increase is especially strong for horizons up to 10 years. Inflation protection from housing is stronger when inflation is persistent, and the hedging capacities of housing regarding unexpected inflation are weak.
Barriers to Accounting: Australian Indigenous Students' Experience

Australian Indigenous people are under-represented in accounting studies and in the accounting profession. As part of an investigation of the cause of this situation such that it can be overcome, this project addresses the relevant study choices of high-school students in Darwin. Through semi-structured interviews with students and teachers, it is found that diverse cultural issues have significant impact on Indigenous students' study options and study success, that there are important differences between urban Indigenous students and remote Indigenous students, and that addressing merely attendance, literacy and numeracy issues is unlikely to make an impact on students' study choices as they relate to accounting.