Miracle-dz/UniFAR-FTUs huggingface dataset:
Spiritual and Religious Coping of Medical Decision Makers for Hospitalized Older Adult Patients.

BACKGROUND Critically ill adult patients who face medical decisions often delegate others to make important decisions. Those who are authorized to make such decisions are typically family members, friends, or legally authorized representatives, often referred to as surrogates. Making medical decisions on behalf of others produces emotional distress. Spirituality and/or religion provide significant assistance to cope with this distress. We designed this study to assess the role of surrogates' spirituality and religion (S/R) coping resources during and after making medical decisions on behalf of critically ill patients. The study's aim was to understand the role that S/R resources play in coping with the lived experiences and challenges of being a surrogate. METHODS Semistructured interviews were conducted with 46 surrogates by trained interviewers. These were audio-recorded and transcribed by research staff. Three investigators conducted a thematic analysis of the transcribed interviews. The codes from inter-rater findings were analyzed, and comparisons were made to ensure consistency. RESULTS The majority (67%) of surrogates endorsed belief in God and a personal practice of religion. Five themes emerged in this study. Personal prayer was demonstrated as the most important coping resource among surrogates who were religious. Trusting in God to be in charge or to provide guidance was also commonly expressed. Supportive relationships from family, friends, and coworkers emerged as a coping resource for all surrogates. Religious and nonreligious surrogates endorsed coping strategies such as painting, coloring, silent reflection, music, recreation, and reading. Some surrogates also shared personal experiences that were transformative as they cared for their ill patients. CONCLUSION We conclude that surrogates use several S/R and other resources to cope with stress when making decisions for critically ill adult patients. The coping resources identified in this study may guide professional chaplains and other care providers to design a patient-based and outcome-oriented intervention to reduce surrogate stress, improve communication, increase patient and surrogate satisfaction, and increase surrogate integration in patient care. We recommend ensuring that surrogates have S/R resources actively engaged in making medical decisions. Chaplains should be involved before, during, and after medical decision making to assess and address surrogate stress. An interventional research-design project to assess the effect of spiritual care on surrogate coping before, during, and after medical decision making is also recommended.
Apolipoprotein A-I directly interacts with extracellular domain 1 of human ABCA1

ABSTRACT ATP-binding cassette transporter A1 (ABCA1) is critical for the generation of nascent high-density lipoprotein (HDL) and plays important roles in cholesterol homeostasis. ABCA1 has two large extracellular domains (ECDs), which may interact directly with apolipoprotein A-I (apoA-I). However, the molecular mechanisms underlying HDL formation and the importance of ABCA1–apoA-I interactions in HDL formation remain unclear. We investigated the ABCA1–apoA-I interaction in photo-activated crosslinking experiments using sulfo-SBED–labeled apoA-I. ApoA-I bound to cells expressing ABCA1, but not to untransfected cells or cells expressing non-functional ABCA1. Binding was inhibited by sulfo-SBED–labeled apoA-I, and crosslinking of sulfo-SBED–labeled apoA-I with ABCA1 was inhibited by non-labeled apoA-I, suggesting that sulfo-SBED–labeled apoA-I specifically binds and crosslinks with functional ABCA1. Proteolytic digestion of crosslinked ABCA1 revealed that apoA-I bound the N-terminal half of ABCA1, and that the first ECD of ABCA1 is an apoA-I binding site. Abbreviations: ABC: ATP-binding cassette; apoA-I: apolipoprotein A-I; ATP: adenosine triphosphate; CHAPS: 3-(3-cholamidepropyl)dimethylammonio-1- propanesulphonate; DTT: dithiothreitol; ECD: extra cellular domain; EDTA: ethylenediaminetetraacetic acid; GFP: green fluorescent protein; HA: hemagglutinin; HDL: high density lipoprotein; HEK: human embryonic kidney; HEPES: 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; sulfo-SBED: (sulfosuccinimidyl-2-[6-(biotinamido)-2-(p-azidobenzamido)hexanoamido] ethyl-1,3ʹ-dithiopropionate; NHS-ester, N-hydroxysuccinimide-ester Graphical Abstract ABCA1 directly interacts with apoA-I with its first extracellular domain for generating nascent HDL.
Effect of phototherapy on oxidant/antioxidant status: a randomized controlled trial

Abstract In order to evaluate the effect of different types of phototherapy on oxidant/antioxidant status in hyperbilirubinemic neonates, an interventional randomized control trial was conducted on 120 neonates ≥35 weeks’ gestational age with indirect hyperbilirubinemia reaching phototherapy level. This study is registered with ClinicalTrials.gov as NCT03074292. Neonates were assigned to three groups; 40 neonates received conventional phototherapy, 40 received intensive phototherapy and 40 received blue light-emitting diodes (LED) phototherapy. Complete blood count (CBC), total serum bilirubin (TSB), total antioxidant capacity (TAC), malondialdehyde (MDA), nitric oxide (NO), copper (Cu), zinc (Zn), and iron (Fe) levels were measured before and 24 hours after phototherapy. TSB decreased postphototherapy in all three groups (p < .05 for all), with significantly lower levels following intensive and LED phototherapy compared to conventional phototherapy (p < .05 for both). TAC decreased postphototherapy in the three groups (p < .05 for all). MDA and NO increased postphototherapy (p < .05 for all), with the intensive phototherapy group having the highest levels followed by the conventional while LED phototherapy group showed the lowest levels in comparison to the other groups (p < .05). Cu, Zn and Fe increased postphototherapy in all three groups (p < .05 for all). Positive correlations were found between postphototherapy TSB with TAC, Cu and Zn (p < .05) and negative correlations with MDA, NO and Fe (p < .05) among neonates of the 3 studied groups. In conclusion, different photo therapies have an impact on oxidant/antioxidant balance and are associated with increased oxidative stress markers with the LED phototherapy being the safest.
HEartLight guided – PUre Pulmonary Vein Isolation Regardless of Concomitant Atrial Substrate: HEURECA Study

It remains unclear whether left atrial low‐voltage area (LALVA) affects atrial tachyarrhythmia recurrence after laser balloon pulmonary vein isolation (PVI) for atrial fibrillation (AF). We prospectively evaluated the outcome of laser balloon PVI in patients with and without LALVA (≤ 0.5 mV) together with surface/intracardiac electrophysiological criteria.
Multi-Temporal Satellite Images on Topsoil Attribute Quantification and the Relationship with Soil Classes and Geology

The mapping of soil attributes provides support to agricultural planning and land use monitoring, which consequently aids the improvement of soil quality and food production. Landsat 5 Thematic Mapper (TM) images are often used to estimate a given soil attribute (i.e., clay), but have the potential to model many other attributes, providing input for soil mapping applications. In this paper, we aim to evaluate a Bare Soil Composite Image (BSCI) from the state of São Paulo, Brazil, calculated from a multi-temporal dataset, and study its relationship with topsoil properties, such as soil class and geology. The method presented detects bare soil in satellite images in a time series of 16 years, based on Landsat 5 TM observations. The compilation derived a BSCI for the agricultural sites (242,000 hectare area) characterized by very complex geology. Soil properties were analyzed to calibrate prediction models using 740 soil samples (0–20 cm) collected of the area. Partial least squares regression (PLSR) based on the BSCI spectral dataset was performed to quantify soil attributes. The method identified that a single image represents 7 to 20% of bare soil while the compilation of the multi-temporal dataset increases to 53%. Clay content had the best soil attribute prediction estimates (R2 = 0.75, root mean square error (RMSE) = 89.84 g kg−1, and accuracy = 74%). Soil organic matter, cation exchange capacity and sandy soils also achieved moderate predictions. The BSCI demonstrates a strong relationship with legacy geological maps detecting variations in soils. From a single composite image, it was possible to use spectroscopy to evaluate several environmental parameters. This technique could greatly improve soil mapping and consequently aid several applications, such as land use planning, environmental monitoring, and prevention of land degradation, updating legacy surveys and digital soil mapping.
Augmented concentrations of CX3CL1 are associated with interstitial lung disease in systemic sclerosis

Background Dysregulation of Fractalkine (CX3CL1) and its receptor CX3CR1 has been linked to the pathobiology of chronic inflammatory conditions. We explored CX3CL1 in systemic sclerosis (SSc) related progressive interstitial lung disease (ILD) and pulmonary hypertension (PH) in two different but complementary sources of biomaterial. Methods We collected lung tissue at the time of lung transplantation at UCLA from SSc-ILD patients (n = 12) and healthy donors (n = 12); and serum samples from the prospective Oslo University Hospital SSc cohort (n = 292) and healthy donors (n = 100). CX3CL1 was measured by ELISA. Cellular sources of CX3CL1/CX3CR1 in lung tissues were determined by immunohistochemistry and immunofluorescence. ILD progression and new onset PH endpoints were analysed. Results CX3CL1 concentrations were increased in SSc in lung tissue as well as in sera. In the UCLA cohort, CX3CL1 was highly correlated with DLCO. In the SSc-ILD lungs, CX3CL1 was identified in reactive type II pneumocytes and airway epithelial cells. CX3CR1 stained infiltrating interstitial mononuclear cells, especially plasma cells. In the Oslo cohort, CX3CL1 correlated with anti-Topoisomerase-I-antibody and lung fibrosis. CX3CL1 was associated with ILD progression in multivariable regression analysis but not PH. Conclusion CX3CL1 is associated with progressive SSc-ILD but not SSc-PH. The CX3CR1/CX3CL1-biological axis may be involved in recruiting antibody secreting plasma cells to SSc lungs, thereby contributing to the immune-mediated pathobiology of SSc-ILD.
How does managed competition affect hospital prices in a social health insurance system? The Colombian case

This paper studies the effect on hospital service prices of a health system reform that allows managed selective contracting and regulation as a means for efficiency and price competition. Cross-sectional data about prices and market structure were analysed from a pool of 20 markets which includes 15 million Colombians. A multilevel regression method comparing three different market settings was performed. The analysis evaluates the effects of insurer choice, hospital quality and market characteristics using a nationwide health services transactional database. A Hirshmann-Herfindahl index was applied to evaluate the markets concentration. Among the results, bilateral monopolies were made evident, both in insurance and hospital markets. Insurer selective contracting policy has the greatest impact on pricing with hospital monopoly heavy effect on health service prices. Colombian government has a challenge in regulating managed competition in order to maintain competition and access to healthcare. Health reforms using market competition as a mechanism for efficiency should follow closely health services market evolution in order to introduce effective regulatory policies.
Interactome mapping defines BRG1, a component of the SWI/SNF chromatin remodeling complex, as a new partner of the transcriptional regulator CTCF

The highly conserved zinc finger CCCTC-binding factor (CTCF) regulates genomic imprinting and gene expression by acting as a transcriptional activator or repressor of promoters and insulator of enhancers. The multiple functions of CTCF are accomplished by co-association with other protein partners and are dependent on genomic context and tissue specificity. Despite the critical role of CTCF in the organization of genome structure, to date, only a subset of CTCF interaction partners have been identified. Here we present a large-scale identification of CTCF-binding partners using affinity purification and high-resolution LC-MS/MS analysis. In addition to functional enrichment of specific protein families such as the ribosomal proteins and the DEAD box helicases, we identified novel high-confidence CTCF interactors that provide a still unexplored biochemical context for CTCF's multiple functions. One of the newly validated CTCF interactors is BRG1, the major ATPase subunit of the chromatin remodeling complex SWI/SNF, establishing a relationship between two master regulators of genome organization. This work significantly expands the current knowledge of the human CTCF interactome and represents an important resource to direct future studies aimed at uncovering molecular mechanisms modulating CTCF pleiotropic functions throughout the genome.
Typhoon/Hurricane-Generated Wind Waves Inferred from SAR Imagery

The wide-swath mode of synthetic aperture radar (SAR) is a good way of detecting typhoon/hurricane winds with a cross-polarization mode. However, its ability to detect wind waves is restricted because of its spatial resolution and nonlinear imaging mechanisms. In this study, we use the SAR-retrieved wind speed, Sentinel-1 SAR wave mode and buoy data to examine fetch- and duration-limited parametric models (denoted H-models), to estimate the wave parameters (significant wave height Hs, dominant wave period Tp) generated by hurricanes or typhoons. Three sets of H-models, in total 6 models, are involved: The H-3Sec model simulates the wave parameters in 3 sections of a given storm (right, left and back); H-LUT models, including the H-LUTI model and H-LUTB model, provide a better resolution of the azimuthal estimation of wind waves inside the storm by analyzing the dataset from Bonnie 1998 and Ivan 2004; and the third set of models is called the H-Harm models, which consider the effects of the radius of the maximum wind speed rm on the wave simulation. In the case of typhoon Krovanh, the comparison with wave-mode measurements shows that the duration-limited models underestimate the high values for the wind-wave Hs, while the fetch models’ results are more accurate, especially for the H-LUTI model. By analyzing 86 SAR wave mode images, it is found that the H-LUTI model is the best among the 6 H-models, and can effectively simulate the wind-wave Hs, except in the center area of the typhoon; root mean square errors (rmse) can reach 0.88 m, and the coefficient correlation (R2) is 0.86. The H-Harm models add rm as an additional factor to be considered, but this does not add significant improvement in performance compared to the others. This limitation is probably due to the fact that the data sets used to develop the H-Harm models have only a limited coverage range, with respect to rm. Applying H-models to RADARSAT-2 ScanSAR mode data, we compare the retrieved wave parameters to collected buoy measurements, showing good consistency. The H-LUTI model, using a fetch-limited function, does the best among these 6 H-models, whose rmse and R2 are 0.86 m and 0.77 for Hs, and 1.06 s and 0.76 for Tp, respectively. Results indicate the potential for H-models to simulate waves generated by typhoons/hurricanes.
Where did inaction go? Towards a broader and more refined perspective on collective actions

While injustice is widespread, collective action against it appears to be rare. This paper argues that this may be because research often focuses on a narrow range of outgroup‐oriented actions, such as demonstrating, signing petitions, that are symbolic of a collective response to injustice. The present work takes a bottom‐up approach to study a broad range of collective and individual actions that people undertake in response to collective injustice. Participants indicated actions they felt they could take (Study 1) and, via interviews, actually had taken (Study 2) in response to human‐induced earthquakes. These studies revealed a broad range of actions, many of which are collective but ingroup‐ (e.g., helping ingroup members) rather than outgroup‐oriented. Study 3 further conceptualized these collective and individual actions by including quantitative measures thereof in an assessment of responses to stressful life events that were collective or individual. Results revealed that, while traditional forms of collective action are rare, ingroup‐oriented and individual level (e.g., social support) responses form distinct dimensions in response to both individual and collective events. This work extends our understanding of responses to collective injustice and suggests the need to broaden the scope of collective action research.
Antimicrobial use in European acute care hospitals: results from the second point prevalence survey (PPS) of healthcare-associated infections and antimicrobial use, 2016 to 2017

Antimicrobial agents used to treat infections are life-saving. Overuse may result in more frequent adverse effects and emergence of multidrug-resistant microorganisms. In 2016–17, we performed the second point-prevalence survey (PPS) of healthcare-associated infections (HAIs) and antimicrobial use in European acute care hospitals. We included 1,209 hospitals and 310,755 patients in 28 of 31 European Union/European Economic Area (EU/EEA) countries. The weighted prevalence of antimicrobial use in the EU/EEA was 30.5% (95% CI: 29.2–31.9%). The most common indication for prescribing antimicrobials was treatment of a community-acquired infection, followed by treatment of HAI and surgical prophylaxis. Over half (54.2%) of antimicrobials for surgical prophylaxis were prescribed for more than 1 day. The most common infections treated by antimicrobials were respiratory tract infections and the most commonly prescribed antimicrobial agents were penicillins with beta-lactamase inhibitors. There was wide variation of patients on antimicrobials, in the selection of antimicrobial agents and in antimicrobial stewardship resources and activities across the participating countries. The results of the PPS provide detailed information on antimicrobial use in European acute care hospitals, enable comparisons between countries and hospitals, and highlight key areas for national and European action that will support efforts towards prudent use of antimicrobials.
Directing Voluntary Temporal Attention Increases Fixational Stability

Our visual input is constantly changing, but not all moments are equally relevant. Visual temporal attention, the prioritization of visual information at specific points in time, increases perceptual sensitivity at behaviorally relevant times. The dynamic processes underlying this increase are unclear. During fixation, humans make small eye movements called microsaccades, and inhibiting microsaccades improves perception of brief stimuli. Here, we investigated whether temporal attention changes the pattern of microsaccades in anticipation of brief stimuli. Human observers (female and male) judged stimuli presented within a short sequence. Observers were given either an informative precue to attend to one of the stimuli, which was likely to be probed, or an uninformative (neutral) precue. We found strong microsaccadic inhibition before the stimulus sequence, likely due to its predictable onset. Critically, this anticipatory inhibition was stronger when the first target in the sequence (T1) was precued (task-relevant) than when the precue was uninformative. Moreover, the timing of the last microsaccade before T1 and the first microsaccade after T1 shifted such that both occurred earlier when T1 was precued than when the precue was uninformative. Finally, the timing of the nearest pre- and post-T1 microsaccades affected task performance. Directing voluntary temporal attention therefore affects microsaccades, helping to stabilize fixation at the most relevant moments over and above the effect of predictability. Just as saccading to a relevant stimulus can be an overt correlate of the allocation of spatial attention, precisely timed gaze stabilization can be an overt correlate of the allocation of temporal attention. SIGNIFICANCE STATEMENT We pay attention at moments in time when a relevant event is likely to occur. Such temporal attention improves our visual perception, but how it does so is not well understood. Here, we discovered a new behavioral correlate of voluntary, or goal-directed, temporal attention. We found that the pattern of small fixational eye movements called microsaccades changes around behaviorally relevant moments in a way that stabilizes the position of the eyes. Microsaccades during a brief visual stimulus can impair perception of that stimulus. Therefore, such fixation stabilization may contribute to the improvement of visual perception at attended times. This link suggests that, in addition to cortical areas, subcortical areas mediating eye movements may be recruited with temporal attention.
Examining Factors Influencing the Viability of Automatic Acoustic Analysis of Child Speech.

Purpose Heterogeneous child speech was force-aligned to investigate whether (a) manipulating specific parameters could improve alignment accuracy and (b) forced alignment could be used to replicate published results on acoustic characteristics of /s/ production by children. Method In Part 1, child speech from 2 corpora was force-aligned with a trainable aligner (Prosodylab-Aligner) under different conditions that systematically manipulated input training data and the type of transcription used. Alignment accuracy was determined by comparing hand and automatic alignments as to how often they overlapped (%-Match) and absolute differences in duration and boundary placements. Using mixed-effects regression, accuracy was modeled as a function of alignment conditions, as well as segment and child age. In Part 2, forced alignments derived from a subset of the alignment conditions in Part 1 were used to extract spectral center of gravity of /s/ productions from young children. These findings were compared to published results that used manual alignments of the same data. Results Overall, the results of Part 1 demonstrated that using training data more similar to the data to be aligned as well as phonetic transcription led to improvements in alignment accuracy. Speech from older children was aligned more accurately than younger children. In Part 2, /s/ center of gravity extracted from force-aligned segments was found to diverge in the speech of male and female children, replicating the pattern found in previous work using manually aligned segments. This was true even for the least accurate forced alignment method. Conclusions Alignment accuracy of child speech can be improved by using more specific training and transcription. However, poor alignment accuracy was not found to impede acoustic analysis of /s/ produced by even very young children. Thus, forced alignment presents a useful tool for the analysis of child speech. Supplemental Material https://doi.org/10.23641/asha.7070105.