Miracle-dz/UniFAR-FTUs huggingface dataset:
Medical skin camouflage: a recovery intervention for female prisoners who self-harm?

Women prisoners comprise 5% of the prison population and are far more likely to inflict harm directly on their bodies than women in the community or male prisoners. Their self-harm challenges the criminal justice system, not least because it may be life threatening and is a predictor of an inflated risk of suicide. Detailed studies of self-harm in prison populations are few, but recent research found that cutting and scratching were the most frequent self-harming methods and, particularly among women in prison, self-strangulation was common, followed by hanging (Hawton et al. 2013). The Hawton group also showed that rates of self-harm by women prisoners are more than ten times higher than among male prisoners (Hawton et al. 2013). Women prisoners also appear to have suffered higher levels of prior psychiatric contacts, alcohol and drug misuse, physical and sexual abuse than their male counterparts (Ministry of Justice, 2012a; 2012b). Healthcare services have significantly improved the management of acute self-harm crises in the community and prison service, but there has been little focus on the recovery from self-harm and those who have to live with the scars that are left behind. The authors argue that female prisoners with self-inflicted scarring may experience psychological distress owing to perceived disfigurement. This can disturb quality of life and capacity to participate in activities such as work and social events in the prison environment and after release. The authors suggest that for those female prisoners with permanent or chronic disfigurement from self-harm, the use of medical skin camouflage can help them to adjust to
How wood fuels' quality relates to the standards: A class-modelling approach

The quality requirements of wood biofuels are regulated by a series of harmonized international standards. These standards define the technical parameter limits that influence the quality of solid biomass as a fuel. In 2014 the European reference standard for solid biofuel was replaced by the International ISO standard. In the case of wood chips, the main difference between the European and International standards is the definition of particle size distribution classes. In this context, this study analyses the quality of wood chips and its variation over the years according to the “former” (EN 14691-4) and “in force” (ISO 17225-4) standards. A Soft Independent Modelling of Class Analogy (SIMCA) model was built to predict the best quality of wood chips and to clarify the relationship between quality and standard parameters, time and changes in the standard regulations. The results show that, compared to the EN standards, classification with the ISO standards increases the samples belonging to the best quality classes and decreases the not classified samples. Furthermore, all the SIMCA models have a high sensitivity (>90%), reflect the differences introduced to the quality standards and are therefore suitable for monitoring the quality of wood chips and their changes.
In Vivo Regulation of Hepatitis B Virus Replication by Peroxisome Proliferators

ABSTRACT The role of the peroxisome proliferator-activated receptor α (PPARα) in regulating hepatitis B virus (HBV) transcription and replication in vivo was investigated in an HBV transgenic mouse model. Treatment of HBV transgenic mice with the peroxisome proliferators Wy-14,643 and clofibric acid resulted in a less than twofold increase in HBV transcription rates and steady-state levels of HBV RNAs in the livers of these mice. In male mice, this increase in transcription was associated with a 2- to 3-fold increase in replication intermediates, whereas in female mice it was associated with a 7- to 14-fold increase in replication intermediates. The observed increases in transcription and replication were dependent on PPARα. HBV transgenic mice lacking this nuclear hormone receptor showed similar levels of HBV transcripts and replication intermediates as untreated HBV transgenic mice expressing PPARα but failed to demonstrate alterations in either RNA or DNA synthesis in response to peroxisome proliferators. Therefore, it appears that very modest alterations in transcription can, under certain circumstances, result in relatively large increases in HBV replication in HBV transgenic mice.
Preliminary study on productive and reproductive performances of Jamunapari, Black Bengal and crossbred goats at Chittagong region of Bangladesh.

The present study was conducted with a view to know the productive and reproductive performance of Jamunapari, Black Bengal and crossbred goats in Chittagong district during the period of May to December 2012. The data on productive and reproductive traits were collected from 324 goats as a whole. In the present study, the birth weight of Jamunapari goats was higher than other crosses. The adult weight of Jamunapari, Black Bengal and crossbred bucks and does were 50.70 ± 3.53, 24.27 ± 1.67 and 40.38 ± 2.90 kg and 45.47 ± 3.78, 21.06 ± 2.33 and 35.72 ± 2.97 kg, respectively. The highest milk yield and lactation period were observed in Jamunapari goats than other crosses. The average age at puberty of Jamunapari, Black Bengal and crossbred goats were 335.00 ± 25.77, 194.12 ± 18.73 and 287.50 ± 22.57 days, respectively. Age at first conception of Jamunapari, Black Bengal and crossbred goats were 381.00 ± 22.54, 217.94 ± 16.87 and 321.25 ± 21.25 days, respectively. Age at first kidding of Jamunapari, Black Bengal and crossbred goats were 534.00 ± 24.58, 368.12 ± 16.96 and 471.25 ± 21.25 days, respectively. The kidding interval of Black Bengal goat was lower i.e. the reproductive performance is better in Black Bengal goat than Jamunapari and crossbred goats. Gestation period of Jamunapari, Black Bengal and crossbred goats were 151.71 ± 8.19, 146.72 ± 7.61 and 147.85 ± 7.74 days, respectively.
Biology of Natural Killer Cells in Cancer and Infection

NK cells are the important cells of the immune system derived from stem cells in the marrow. Their physiology is tightly regulated to control proliferation, cytotoxicity and cytokine production. In cancer, NK cells may be abnormal due to the cancer itself or possibly related to its therapy. The finding of class I recognizing inhibitory receptors may play a role in stem cell transplant rejection, immune surveillance and cancer immunotherapy. NK cells should no longer be thought of as direct cytotoxic killers alone, as they clearly play a critical role in cytokine production which may be important to control cancer and infection. Understanding NK cell function and homing may lead to novel therapeutic strategies for the treatment of human disease.
The role of the meniscus in the anterior-posterior stability of the loaded anterior cruciate-deficient knee. Effects of partial versus total excision.

The effects of progressive removal of the menisci on the anterior-posterior force-versus-displacement response of the anterior cruciate-deficient knee were studied in fresh cadaver specimens at 20 degrees of flexion without and with tibial-femoral contact force (joint load). In the absence of joint load, removal of the medial meniscus increased total anterior-posterior laxity measured at 200 newtons of applied tibial force by 10 per cent, and subsequent lateral meniscectomy produced an additional 10 per cent increase. When a bucket-handle tear of the medial meniscus was removed, the application of joint load caused the tibia to displace (subluxate) forward on the femur, thereby changing the balance condition of the knee. Subsequent removal of the remainder of the medial meniscus and complete lateral meniscectomy both produced additional smaller anterior tibial subluxations. Changes in total anterior-posterior laxity due to progressive meniscectomy in the loaded knee were dependent on both the amount of applied anterior-posterior force and the level of compressive force. At 200 newtons of anterior-posterior tibial force, increases in laxity in the loaded knee due to progressive meniscal removal were not significantly different than those recorded in the unloaded condition. At applied forces of fifty newtons or less, the laxities for loaded specimens were always significantly less than those for unloaded specimens at comparable stages of meniscal removal. Bilateral meniscectomy had no significant effect on the posterior response curve, as posterior tibial translation was effectively checked by the intact posterior cruciate ligament. (ABSTRACT TRUNCATED AT 250 WORDS)
Comparative 6-month clinical study of a subepithelial connective tissue graft and acellular dermal matrix graft for the treatment of gingival recession.

BACKGROUND Different techniques have been proposed for the treatment of gingival recessions. This study compared the clinical results of gingival recession treatment using a subepithelial connective tissue graft and an acellular dermal matrix allograft. METHODS Nine patients with bilateral Miller Class I or II gingival recessions were selected. A total of 30 recessions were treated and randomly assigned to the test group and the contralateral recession to the control group. In the control group, the exposed root surfaces were treated by the placement of a connective tissue graft in combination with a coronally positioned flap; in the test group, an acellular dermal matrix allograft was used as a substitute for palatal donor tissue. Probing depth, clinical attachment level, gingival recession, and width of keratinized tissue were measured 2 weeks prior to surgery and 3 and 6 months postsurgery. RESULTS There were no statistically significant differences between the test group and the control group in terms of recession reduction, clinical attachment gain, and reduction in probing depth. The control group had a statistically significant increased area of keratinized tissue after 3 months compared to the test group. Both procedures, however, produced an increase in keratinized tissue after 6 months, with no statistically significant difference. CONCLUSION The acellular dermal matrix allograft may be a substitute for palatal donor tissue in root coverage procedures.
A novel CD40 ligand mutation in a patient with pneumonia, neutropenia, and hyperimmunoglobulin M phenotype.

I Mohammadzadeh, L Shahbaznejad, N Wang, E Farhadi, A Aghamohammadi, L Hammarstrom, N Rezaei 1 Non-Communicable Pediatric Diseases Research Center, Babol University of Medical Sciences, Babol, Iran 2 Research Center for Immunode ciencies, Children’s Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran 3 Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institute at the Karolinska University Hospital Huddinge, Stockholm, Sweden 4 Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran 5 Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Engaging Hill-Sachs lesion: is there an association between this lesion and findings on MRI?

OBJECTIVE The objective of our study was to see whether there is an association between engagement on physical examination and the location or size of a Hill-Sachs lesion and the presence and degree of glenoid bone loss as assessed on MRI. MATERIALS AND METHODS Thirty-three consecutive patients (32 males and one female) with a history of anterior shoulder dislocation who underwent preoperative MRI and arthroscopy at our institution and were tested for engagement on physical examination over a 9-month period were included in the study. Two blinded readers reviewed each study independently and documented the presence and size of the Hill-Sachs lesion, location of the Hill-Sachs lesion with a modified biceps angle, and presence and size of glenoid bone loss. Statistical analysis included the Mann-Whitney, logistic regression, Pearson correlation, and intraclass correlation tests. RESULTS Eleven patients had evidence of an engaging Hill-Sachs lesion on physical examination and 22 did not. There was no statistically significant difference between any of the dimensions or overall area of the Hill-Sachs lesion when comparing the group with an engaging Hill-Sachs lesion and the group with a nonengaging lesion (surface area, 3.60 vs 3.23 cm(3), respectively; p = 0.272). There was a trend for a larger biceps angle in the engaging group without a statistically significant difference (mean, 154.5° vs 143.9°; p = 0.069). There was a statistically significant difference in the amount of glenoid bone loss in the engaging group compared with the nonengaging group (mean, 20.2% vs 6.0%; p = 0.001). CONCLUSION There is a significant association between an engaging Hill-Sachs lesion on physical examination and the degree of glenoid bone loss as well as a trend toward increased engagement with more medially oriented Hill-Sachs lesions. These findings show the importance of considering both the Hill-Sachs lesion and glenoid bone loss when evaluating patients with engagement.
Dynamic resource allocation exploiting mobility prediction in mobile edge computing

In 5G mobile networks, computing and communication converge into a single concept. This convergence leads to introduction of Mobile Edge Computing, where computing resources are distributed at the edge of mobile network, i.e., in base stations. This approach significantly reduces delay for computation of tasks offloaded from users' devices to cloud and reduces load of backhaul. However, due to users' mobility, optimal allocation of the computational resources at the base stations might change over time. The computational resources are allocated in a form of Virtual Machines (VM), which emulate a given computer system. User's mobility can be solved by VM migration, i.e., transfer of VM from one base station to another. Another option is to find a new communication path for exchange of data between the VM and the user. In this paper we propose an algorithm enabling flexible selection of communication path together with VM placement. To handle dynamicity of the system, we exploit prediction of users' movement. The prediction is used for dynamic VM placement and to find the most suitable communication path according to expected users' movement. Comparing to state of the art approaches, the proposal leads to reduction of the task offloading delay between 10% and 66% while energy consumed by user's equipment is kept at similar level. The proposed algorithm also enables higher arrival rate of the offloading requirements.
Clovis Paleoecology and Lithic Technology in the Central Rio Grande Rift Region, New Mexico

Abstract Clovis sites occur throughout the southwestern United States and northwestern Mexico, but are poorly documented in the central Rio Grande rift region. Here, we present data from two relatively unknown Clovis projectile point assemblages from this region: the first is from the Mockingbird Gap Clovis site and the second is from a survey of the surrounding region. Our goals are to reconstruct general features of the paleoecological adaptation of Clovis populations in the region using raw material sourcing and then to compare the point technology in the region to other Clovis assemblages in the Southwest and across the continent. Our results show that both assemblages were manufactured from similar suites of raw materials that come almost exclusively from the central Rio Grande rift region and the adjacent mountains of New Mexico. Additionally, we show that Clovis projectile points in the study region are significantly smaller than the continental average. Our results suggest that Clovis populations in this region operated within a large, well-known, and relatively high-elevation territory encompassing much of northern and western New Mexico.
A micromechanical numerical modelling approach for the homogenisation of grouted sands

The paper presented deals with the investigation of the mechanical behaviour of sands grouted with a micro-fine cement grout. Contrary to most existing works on cemented or grouted sands, which rely on a macroscopic framework to identify the behaviour of such composite granular media from macroscopic triaxial tests, a multiscale modelling approach is retained in the present work based on the homogenisation method of periodic media. The first part of the work is dedicated to the study of the effect of the elastic characteristics of the constituents and of the grout saturation within the void space on the elastic behaviour of the grouted sand. The second part addresses the non-linear behaviour of the equivalent material by taking into account the damage behaviour of the grout.
Efectividad de un programa grupal psicoeducativo para la depresión mayor en atención primaria: ensayo clínico controlado aleatorizado

La prevalencia de la depresion mayor en Europa es del 8,56% (1) y especificamente del 5-16% en pacientes de atencion primaria (AP), siendo la tercera causa de consulta en la AP de salud (2). La mayoria de guias de practica clinica (GPC) para el manejo de la depresion recomiendan intervenciones psicoeducativas y psicoterapias breves como primer paso de accion en el protocolo de tratamiento (3). En relacion a la psicoeducacion, existe evidencia en el tratamiento de la depresion en el adulto (3-4), en la reduccion de los sintomas depresivos y en la prevencion de la depresion en pacientes de AP (5). Sin embargo, existen pocos estudios controlados que hayan incluido los aspectos del cuidado personal y estilo de vida saludable (dieta, ejercicio fisico, dormir) conjuntamente con tecnicas cognitivo-conductuales dentro de la psicoeducacion y que hayan demostrado ser eficaces. El objetivo principal de nuestro estudio (6) era evaluar la efectividad de esta intervencion en pacientes con sintomas depresivos en AP y determinar si la mejora en los sintomas depresivos estaba asociada con una mejora en la calidad de vida. Tambien estabamos interesados en analizar que tipo de poblacion se podria beneficiar mas de esta intervencion, si la poblacion con sintomas “leves” o “moderados”. Este es un estudio multicentrico aleatorizado, controlado, que se llevo a cabo entre Diciembre del 2008 y Abril del 2010, en 12 equipos de AP de Barcelona. Se incluyeron 231 pacientes mayores de 20 anos con un diagnostico de depresion mayor segun el ICD-10 y sintomatologia depresiva leve/moderada segun el Beck Depression Inventory ( BDI ≥10 y <30), que eran reclutados a traves del medico y la enfermera de AP. Del total de pacientes, 85 tenian depresion leve (BDI ≤18) y 146 depresion moderada (BDI ≥19). El grupo de intervencion (GI) (n = 119) recibio un programa grupal psicoeducativo (12 sesiones, semanales, 90 minutos, liderados por dos enfermeras) y el grupo control (GC) (n = 112) recibio la atencion habitual. Los pacientes fueron evaluados al inicio del estudio y a los 3, 6 y 9 meses. Las principales medidas de resultado fueron el BDI, EuroQoL-5D y la remision de los sintomas basado en el BDI (BDI ≤11). Efectividad de un programa grupal psicoeducativo para la depresion mayor en atencion primaria: ensayo clinico controlado aleatorizado.
Potent Inhibition of Arterial Smooth Muscle Tonic Contractions by the Selective Myosin II Inhibitor, Blebbistatin

Blebbistatin is reported to be a selective and specific small molecule inhibitor of the myosin II isoforms expressed by striated muscles and nonmuscle (IC50 = 0.5–5 μM) but is a poor inhibitor of purified turkey smooth muscle myosin II (IC50 ∼80 μM). We found that blebbistatin potently (IC50 ∼3 μM) inhibited the actomyosin ATPase activities of expressed “slow” [smooth muscle myosin IIA (SMA)] and “fast” [smooth muscle myosin IIB (SMB)] smooth muscle myosin II heavy-chain isoforms. Blebbistatin also inhibited the KCl-induced tonic contractions produced by rabbit femoral and renal arteries that express primarily SMA and the weaker tonic contraction produced by the saphenous artery that expresses primarily SMB, with an equivalent potency comparable with that identified for nonmuscle myosin IIA (IC50 ∼5 μM). In femoral and saphenous arteries, blebbistatin had no effect on unloaded shortening velocity or the tonic increase in myosin light-chain phosphorylation produced by KCl but potently inhibited β-escin permeabilized artery contracted with calcium at pCa 5, suggesting that cell signaling events upstream from KCl-induced activation of cross-bridges were unaffected by blebbistatin. It is noteworthy that KCl-induced contractions of chicken gizzard were less potently inhibited (IC50 ∼20 μM). Adult femoral, renal, and saphenous arteries did not express significant levels of nonmuscle myosin. These data together indicate that blebbistatin is a potent inhibitor of smooth muscle myosin II, supporting the hypothesis that the force-bearing structure responsible for tonic force maintenance in adult mammalian vascular smooth muscle is the cross-bridge formed from the blebbistatin-dependent interaction between actin and smooth muscle myosin II.
De Novo Synthesis of Amino Acids by the Ruminal Bacteria Prevotella bryantii B14,Selenomonas ruminantium HD4, and Streptococcus bovis ES1

ABSTRACT The influence of peptides and amino acids on ammonia assimilation and de novo synthesis of amino acids by three predominant noncellulolytic species of ruminal bacteria, Prevotella bryantii B14, Selenomonas ruminantiumHD4, and Streptococcus bovis ES1, was determined by growing these bacteria in media containing 15NH4Cl and various additions of pancreatic hydrolysates of casein (peptides) or amino acids. The proportion of cell N and amino acids formed de novo decreased as the concentration of peptides increased. At high concentrations of peptides (10 and 30 g/liter), the incorporation of ammonia accounted for less than 0.16 of bacterial amino acid N and less than 0.30 of total N. At 1 g/liter, which is more similar to peptide concentrations found in the rumen, 0.68, 0.87, and 0.46 of bacterial amino acid N and 0.83, 0.89, and 0.64 of total N were derived from ammonia by P. bryantii, S. ruminantium, andS. bovis, respectively. Concentration-dependent responses were also obtained with amino acids. No individual amino acid was exhausted in any incubation medium. For cultures of P. bryantii, peptides were incorporated and stimulated growth more effectively than amino acids, while cultures of the other species showed no preference for peptides or amino acids. Apparent growth yields increased by between 8 and 57%, depending on the species, when 1 g of peptides or amino acids per liter was added to the medium. Proline synthesis was greatly decreased when peptides or amino acids were added to the medium, while glutamate and aspartate were enriched to a greater extent than other amino acids under all conditions. Thus, the proportion of bacterial protein formed de novo in noncellulolytic ruminal bacteria varies according to species and the form and identity of the amino acid and in a concentration-dependent manner.