Miracle-dz/UniFAR-FTUs huggingface dataset:
Randomised, Controlled, Cross-Over Trial of Soy Protein with Isoflavones on Blood Pressure and Arterial Function in Hypertensive Subjects

Objective: To examine the effects of dietary soy/isoflavones on 24 hr blood pressure profiles and arterial function [systemic arterial compliance (SAC), pulse wave velocity (PWV) and brachial arterial flow mediated vasodilation (FMD)] compared to non legume-based plant protein without isoflavones, in hypertensive subjects. Design: In a 6 month double-blind, placebo controlled, cross-over trial, 41 hypertensive subjects (26 men, 15 postmenopausal women), 30–75 years, received soy cereal (40 g soy protein, 118 mg isoflavones) and gluten placebo cereal, each for 3 months. Results: Thirty-eight subjects completed protocol with results expressed as mean or mean change (±SEM) with each intervention. Soy increased urinary isoflavones (daidzein: 8-fold; genistein: 8-fold; equol: 9-fold; ODMA: 18-fold) with no change during gluten placebo. There was no difference in the change in individual 24 hr ambulatory BP parameters (SBP: 2 ± 2 vs −1 ± 1 mmHg, p = 0.21; DBP: 1 ± 1 vs −1 ± 1 mmHg, p = 0.06) central BP (cSBP: −4 ± 2 vs 0 ± 2 mmHg, p = 0.2) or the change in arterial function (FMD: 0.3 ± 0.5 vs −0.2 ± 0.5%, p = NS; SAC: 0.02 ± 0.02 vs −0.02 ± 0.02 U/mmHg, p = NS; PWV central: −0.2 ± 0.2 vs 0.0 ± 0.2 m/sec, p = NS; PWV peripheral: 0.01 ± 0.3 vs −0.4 ± 0.4 m/sec, p = NS) noted between interventions. Analysis of the area under curve of 24 hr BP outputs demonstrated that soy protein compared to gluten protein resulted in higher 24 hr systolic BP by 2.3 mmHg (p = 0.003), a higher daytime systolic BP by 3.4 mmHg (p = 0.0002) and a higher daytime diastolic BP by 1.4 mmHg (p = 0.008). Overall 24 hr diastolic BP, night systolic BP and night diastolic BP were not significantly different between groups. Furthermore, soy protein compared to gluten protein resulted in higher 24 hr heart rates by 3.5 bpm (p < 0.0001). Conclusions: In hypertensive subjects, compared to gluten placebo, soy dietary supplementation containing isoflavones had no effect on arterial function, on average 24 hr ambulatory blood pressure parameters or central blood pressure in men and women with hypertension. Area under the curve of 24 hr profiles demonstrated that daytime BP was higher after soy compared to gluten.
Comparison of Astym Therapy and Kinesiotaping for Rotator Cuff Tendinopathy in Diabetic Patients:Randomized Controlled Trial

Background: Rotator cuff tendinopathy is a significant problem among diabetics that frequently restricts patient’s activity in terms of pain and disability. The purpose of this study was to compare between the effect of Astym therapy and kinesiotaping in treating diabetic patients with chronic rotator cuff tendinopathy. Methods: 56 diabetic patients diagnosed with chronic rotator cuff tendinopathy were randomly assigned into Astym therapy group (n=28) or kinesiotaping group (n= 28). All patients received conventional program in addition to Astym treatment or Kinesiotaping for 24 sessions (2times/week). Patients were assessed at baseline and at the end of corresponding intervention with visual analogy scale (VAS) for pain intensity, shoulder disability questioner (SDQ) for shoulder disability, and electrogoniometer for shoulder range of motion. Results: For the 56 study participants (21 males and 35 females; mean age=41.9±6.9) years there were significant differences in all measuring outcomes in both group when compared to baseline measurements (p<0.05). Post treatment comparison showed a significant reduction in pain score in favour of kinesio taping group with no significant differences in SDQ score or active shoulder range of motion between the two groups (p > 0.05). Conclusion: kinesiotaping appears to be more effective than Astym therapy in reducing pain for diabetic patients with chronic rotator cuff tendinopathy.
Evangelicalism in Modern Britain: A History from the 1730s to the 1980s

This major textbook is a newly researched historical study of Evangelical religion in its British cultural setting from its inception in the time of John Wesley to charismatic renewal today. The Church of England, the Church of Scotland and the variety of Nonconformist denominations and sects in England, Scotland and Wales are discussed, but the book concentrates on the broad patterns of change affecting all the churches. It shows the great impact of the Evangelical movement on nineteenth-century Britain, accounts for its resurgence since the Second World War and argues that developments in the ideas and attitudes of the movement were shaped most by changes in British culture. The contemporary interest in the phenomenon of Fundamentalism, especially in the United States, makes the book especially timely.
Desadaptación a la vida en las grandes alturas

Contiene: La ciudad minera de Cerro de Pasco. Breve resena geografica, climatica, economica e historica; Caracteristicas fisiologicas del nativo de altura. Aportes de las investigaciones sobre adaptacion a la altura realizadas en el Peru; Antecedentes clinicos y fisiologicos del Mal de Montana cronico; Analisis estadistico; Resultados generales; Mortalidad en Cerro de Pasco; La edad como factor agravante del Mal de Montana cronico; Las enfermedades respiratorias y el Mal de Montana cronico; Cefaleas y otros sintomas neurologicos; La migracion estacional en Cerro de Pasco: pasado y presente; Ocupacion minero y el Mal de Montana cronico; El riesgo del Mal de Montana cronico: enfoque multifactorial; Tratamiento del Mal de Montana cronico
Dispersion of compound muscle action potential in hereditary neuropathies and chronic inflammatory demyelinating polyneuropathy

Distal compound muscle action potential (DCMAP) dispersion, defined as a DCMAP duration ≥9 ms, and proximal‐distal (P‐D) CMAP dispersion are considered useful in the electrodiagnosis of chronic inflammatory demyelinating polyneuropathy (CIDP). Distal and P‐D CMAP dispersion have not been fully studied in hereditary neuropathies, and it is not known whether these measures distinguish hereditary from acquired demyelination. We compared DCMAP duration and P‐D CMAP dispersion in 91 genetically characterized hereditary neuropathies and 33 subjects with CIDP. DCMAP dispersion was more frequent in nerves affected by CIDP (41.5%) than in Charcot–Marie–Tooth disease (CMT)1A (24.4%), CMT1B (7.4%), hereditary neuropathy with liability to pressure palsies (HNPP) (10.5%), or CMTX (9.8%). P‐D CMAP dispersion was more frequent in CIDP (27.7% of nerves) than in hereditary neuropathies (16.3%) when applying American Academy of Neurology (AAN) criteria; however, its frequency was similar in CIDP and the hereditary neuropathies using the more restrictive criteria of the American Association of Neuromuscular and Electrodiagnostic Medicine (AANEM). Although dispersion is more common in CIDP than in the hereditary neuropathies, DCMAP and P‐D dispersion occur in at least one motor nerve in a significant proportion of hereditary neuropathies, and cannot be used in isolation to distinguish acquired from hereditary demyelination. Muscle Nerve, 2006
Semigroups with apartness

Proving a constructive version of the Spectral Mapping Theorem, Bridges and Havea used a constructive semigroup with inequality in . This motivated us to achieve a little progress in that direction. The starting point is the structure (S,=,≠,·) called a semigroup with apartness. Our primary objective is to prove isomorphism theorems for such constructive semigroups. In doing so our main ideas and notions come from .
Embattled Avant-Gardes: Modernism’s Resistance to Commodity Culture in Europe

Preface Introduction PART ONE: EARLY AVANT-GARDE MODERNISM 1. Intellectuals, Commodity Culture, and Religions of Art in the Nineteenth Century 2. F.T. Marinetti 3. Guillaume Apollinaire 4. Wassily Kandinsky PART TWO: VARIETIES OF INTERWAR MODERNISM 5. The Rise and Fall of Design Modernism: Bauhaus, De Stijl, and Purism 6. Futurism and Its Modernist Rivals in Fascist Italy 7. Andre Breton's Surrealism 8. The Critical Modernism of Herbert Read Conclusion Notes Index
Comparison of enzyme immunoassays detecting Helicobacter pylori specific IgG in serum and saliva with endoscopic and biopsy findings in patients with dyspepsia.

PURPOSE To compare the performance of two indirect enzyme-linked immunosorbent assays (ELISA) detecting Helicobacter pylori (HP)-specific IgG antibodies in serum and saliva with endoscopic observations and histologic findings of biopsies from dyspeptic patients, in an area of high HP prevalence. MATERIALS AND METHODS Sera, saliva and antral biopsies were obtained from 55 dyspeptic patients. IgG antibodies against HP were assayed in sera and saliva utilizing two indirect ELISAs. Biopsies were processed according to standard procedures in order to detect histological changes and the presence or absence of Helicobacter pylori. Laboratory data thus obtained were compared and statistically analyzed. RESULTS Forty-two (76.36%) biopsies were positive for HP. The organisms were detected in 4 of 16 (25%) cases with normal endoscopic findings, in all 16 cases of gastritis and in 22 of the 23 (95.6%) cases of duodenal ulcers (DU). Serum and saliva HP-specific IgG antibodies were detected in 4 normal cases with positive biopsies, in 12 and 14 cases of gastritis, respectively, and in all 22 (100%) biopsy positive cases of DU. The sensitivities of the serum and saliva tests were 90.5% and 95%, respectively, while the specificities were 84.5% and 70%, respectively. CONCLUSION Due to their high sensitivity and specificity in diagnosing HP-associated DU and gastritis, serum and saliva antibody testing seems to offer a valuable alternative to invasive procedures especially in areas of high HP prevalence such as ours; saliva antibody testing is simple and practical especially in children and in difficult patients who resent venipuncture.
Screening of Indian plants for antifertility activity.

The antifertility effects of 32 plants indigenous to India during early and late pregnancy were studied in female rats. The plant materials were separately extracted by 50% ethanol 90% ethanol distilled water and petroleum ether and acetone. Plant materials with a resorptive activity greater than 50% were Abrus precatorius Linn. In petroleum ether (60%) Embelia ribes Burm. in 50% ethanol (66.6%) Moringa pterygospermnm in 50% ethanol (60%) Terminalia arjuna W. & A. in 50% ethanol (60%) and Cichorium intybus L. in 50% ethanol (84%).
EDI-Enabled Channel Transformation: Extending Business Process Redesign beyond the Firm

This paper examines the relationship between process reengineering and channel performance for firms implementing electronic data interchange (EDI) ordering within the U.S. grocery industry. Both quantitative and qualitative data sources are combined to demonstrate that channel transformation (interorganizational reengineering) involving both technological innovation (EDI) and redesign of replenishment processes enables performance improvements more than an order of magnitude greater than implementation of EDI ordering alone. New replenishment processes, enabled by EDI, provide retailers with 50-100 percent higher inventory turns for products using continuous replenishment processes (CRP) relative to retailer performance using traditional ordering processes. Firms adopting EDI for ordering without reengineering ordering processes have failed to realize statistically significant improvements in inventory levels or stockouts. This demonstrates the potential for extending the business process reengineering concept to include the entire supply chain.
Determinants of effective productivity among service workers: the case of nurses in Botswana

The study proposes a measure of effective productivity among service workers and seeks a parsimonious predictive model of “effective productivity” among nurses in Botswana. Employee productivity has become a concern of organisations in all economic sectors world wide. In Botswana, it has also become a national priority issue and has been listed as one of the goals of the long term vision for Botswana due to perceived low productivity among the workforce. Productivity among nurses is of special significance because of their critical role in the primary health care system. Nurses working under local government control in Botswana provide a good case study since they all have to perform certain routine activities from which their productivity could be measured and compared. Self completed anonymous questionnaires were used to collect the relevant data from all health facilities under local government control in Botswana. A representative sample of 325 questionnaires were returned and analysed. Chi-squared test of association was used to identify univariate factors associated with effective productivity from among a list of 38 variables. Hierarchical stepwise multiple logistic regression analysis was used to identify a predictive model for effective productivity among nurses. Thirteen of the 38 variables were found to be significant univariate predictors of effective productivity (p<0.05). Only eight of these factors were retained during a search for a parsimonious predictive model. These in order of importance were midwifery training, involvement with the Village Development Committee, involvement in making health policies, peer support, religious affiliation, ability to complete the Botswana Obstetric Record, quality of health after posting and involvement with the community. The overall impact of these factors was found to be additive. The results underline the importance of midwifery training for effective productivity among nurses in Botswana. It is concluded that all nurses in Botswana should be encouraged and accorded the opportunity to do midwifery training. Nurses should further be encouraged to become more involved in the communities in which they work, as well as develop supportive relationships and a friendly atmosphere at the work place.
Hepatoprotective Effect of Gallotannin-enriched Extract Isolated from Gall on Hydrogen Peroxide-induced Cytotoxicity in HepG2 Cells

Background: Gall (Galla Rhois [GR]) is known to have antibacterial, anti-inflammatory, antimetastatic, and anti-invasion activities and exert hepatoprotective effects. However, the hepatoprotective effects of gallotannin-enriched GR (GEGR) and their mechanisms have not yet been investigated. Objective: The potential protective effect of GEGR against hepatotoxicity induced by hydrogen peroxide (H2O2) was investigated. Materials and Methods: Changes in cell viability, apoptosis protein expression, and reactive oxygen species (ROS) generation were determined in HepG2 cells that were pretreated with four different concentrations of GEGR (6.25–50 μg/ml) for 24 h before H2O2exposure. Results: GEGR consisted of gallotannin (69.2%), gallic acid (26.6%), and methyl gallate (4.2%) and showed remarkable 2,2-diphenyl-1-picrylhydrazyl scavenging activity (inhibitory concentration 50% = 0.212 μg/ml). The lethal dose 50% and effective dose 50% values for the response of HepG2 cells to GEGR were determined to be 178 and 6.85 μg/ml, respectively. Significant reductions in the immunofluorescence intensity indicating apoptosis were also detected in the nuclei of HepG2 cells stained with 4',6-diamidino-2-phenylindole and Annexin V after GEGR treatment. The Bax/Bcl-2 ratio and active caspase-3 level were higher in H2O2 + vehicle-treated cells. However, these levels gradually decreased to those of the No-treated group in the GEGR pretreated group even though little or no decrease was observed in response to low GEGR concentrations. Furthermore, the GEGR pretreated group showed a reduced level of 2-′,7-′-dichlorofluorescein diacetate stained cells, indicating ROS generation relative to the H2O2 + vehicle-treated group. Conclusion: The results of this study provide strong evidence that GEGR can prevent cell death induced by H2O2in HepG2 cells through the induction of antioxidant conditions. Abbreviations used: COX: Cyclooxygenase; DAPI: 4',6-diamidino-2-phenylindole; DMSO: Dimethyl sulfoxide; DPPH: 2,2-diphenyl-1-picrylhydrazyl; GEGR: Gallotannin-enriched Galla Rhois; GR: Galla Rhois; HPLC: High-performance liquid chromatography; H2O2: Hydrogen peroxide; MMP: Metallopeptidase; MTT: 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide; ROS: Reactive oxygen species; UV-Vis: Ultraviolet-visible.
The most encountered groups of genetic disorders in Giza Governorate, Egypt.

This study presents the prevalence, relative frequency, and analysis of genetic diseases/malformations in 73260 individuals. Cases included were ascertained from: Pediatric outpatient clinics of two governmental hospitals and two primary health care centers (PHCCs) in Giza Governorate; Neonatal intensive care unit (NICU) in the selected hospitals and Outpatients Human Genetics Clinics (NRC). 62819 persons visited the outpatients clinics of selected hospitals and PHCCs in Giza governorate. Out of these persons 731 cases (1.16%) proved to have known genetic disorders or malformations. 7755 neonates were delivered in the selected hospitals. Out of these neonates 666 newborns entered NICU and 3% (20 neonates) of them had genetic or congenital disorders. Also, 2686 patients were ascertained from the Human Genetics Clinics, NRC. The overall parental consanguinity rate among the 3417 diagnosed cases was 55%, ranging from 29.5-75%. The study showed a high prevalence of genetic/malformation disorders among Egyptians, with frequencies comparable to other Arab populations (Tab. 4, Ref. 25). Full Text (Free, PDF) www.bmj. sk.
Respiratory syncytial virus proteins: identification by immunoprecipitation

The proteins of respiratory syncytial virus have not been clearly identified due to the lability of the virus and difficulties in its purification. We have pulse-labeled respiratory syncytial virus with [35S]methionine and [35S]cysteine and analyzed cell lysates by polyacrylamide gel electrophoresis. Five 35S-labeled viral proteins ranging in molecular weight from 21,000 to 73,000 (VP73, VP44, VP35, VP28, and VP21) were easily discernable above background cellular proteins. Treatment of the infected cells with 0.15 M NaCl before labeling suppressed host cell protein synthesis and allowed clearer visualization of the five viral proteins by polyacrylamide gel electrophoresis. Three glycoproteins (VGP 92, VGP 50, and VGP 17) were also identified after labeling with [3H]glucosamine. Five of these polypeptides (VP51, VP44, VP35, VP28, and VGP92) were shown to be antigenically active because they could be immunoprecipitated with anti-respiratory syncytial virus antibody produced in New Zealand white rabbits, cotton rats, and humans before analysis by polyacrylamide gel electrophoresis.
Location of tumour necrosis factor a by immunohistochemistry in chronic inflammatory bowel disease

This study determined the location and tissue density of cells immunoreactive for tumour necrosis factor a (TNF a) in intestinal specimens from 24 patients with chronic inflammatory bowel disease (15 with Crohn's disease, nine with ulcerative colitis) and 11 controls. There was significantly increased density of TNF a immunoreactive cells in the lamina propria of both ulcerative colitis and Crohn's disease specimens, although the distribution of these cells differed in the two conditions. In ulcerative colitis most of the TNF a immunoreactivity was seen in the subepithelial macrophages, with comparatively less in the deep lamina propria, while in Crohn's disease immunoreactive cells were distributed evenly throughout the lamina propria. Increased submucosal immunoreactivity was found only in Crohn's disease, in which TNF a positive macrophages tended to cluster around arterioles and venules, often infiltrating and disrupting vascular endothelium. It is sug-gested that this degree of TNF a production probably contributes significantly to the pathogenesis of both Crohn's disease and ulcerative colitis, by impairing the integrity of epithelial and endothelial membranes, increasing inflammatory cell recruitment, and by prothrombotic effects on the vascular endothelium. study we immunohistochemistry to determine the distribution and density ofTNF a containing cells, in the mucosa and submucosa of patients with chronic inflammatory bowel disease.
Anxiety and the Allocation of Attention to Threat

Using a probe detection technique we have recently demonstrated that anxious subjects consistently deploy attention towards threat-related stimuli, whereas non-anxious controls tend to move attention away from such material (MacLeod, Mathews, & Tata, 1986). The current study employed the same paradigm but attempted to distinguish the role of trait and state anxiety by testing high- and low-trait students when state anxiety was relatively low (12 weeks before a major examination) and again when it was relatively high (one week before this examination). High-trait subjects alone tended to shift attention towards generally threatening material on both test occasions. Results for examination-related stimuli were more complex. Increased proximity to the examination was associated with an increase in attentional bias towards such threat stimuli in high-trait subjects, but with increased attentional avoidance of such stimuli in low-trait subjects. It is suggested that the attentional response to currently relevant stress-related stimuli may be associated with neither trait nor state anxiety alone, but with an interactive function involving both these variables. These results are discussed in relation to existing models of emotion and cognition, and alternative interpretations of the findings are considered.
Inter-laboratory comparison of cytogenetic endpoints for the biomonitoring of radiological workers.

PURPOSE The evaluation of different cytogenetic endpoints of radiation damage for the biomonitoring of contract workers temporarily employed at nuclear power plants. MATERIALS AND METHODS Blood samples from six donors were irradiated in vitro with doses ranging from 0.1 to 2Gy 60Co gamma-rays. Compared were a conventional analysis for dicentrics, the conventional micronucleus (MN) assay, the centromere micronucleus assay using p82H and an alphaAllCen pancentromeric probe, and tricolour FISH with chromosome 2, 4 and 8 DNA probes for the scoring of translocations. RESULTS Agreement in the number of MN between Giemsa-and propidium iodine fluorescence-stained preparations was obtained. The control samples showed higher centromere positivity for the MN after FISH with the p82H probe compared with the alphaAllCen probe. The MN results with both probes showed a slight but systematic increase in the number of centromere-positive MN with dose, indicating that radiation, although principally clastogenic, also has aneuploidogenic properties. The values of the genomic translocation frequency (FG) derived from the observed translocation frequencies were systematically higher than the dicentric yields. Comparing the sensitivity of the different methods with restriction of the scoring time to 1 day for biomonitoring purposes, the centromere micronucleus assay had the lowest dose detection limit (0.1 to 0.2 Gy). CONCLUSION This study shows that at present only the centromere micronucleus assay can combine high sensitivity with a reasonable scoring time for the biomonitoring of relatively large populations.
Obesity and mortality from cancer.

Laboratory investigators have long known that animals in which energy intake is reduced to about 60 percent of the intake of animals that are fed as much as they want have a considerably lower incidence of cancer than the control animals. This finding apparently holds true for viral, chemical, and even spontaneous carcinogenesis. Evidence from studies in humans has been largely compatible with these laboratory findings and is applicable to a wide spectrum of sites and types of tumors. Yet this evidence has not stimulated the development of programs to prevent cancer by weight control. There are several reasons for .