Miracle-dz/UniFAR-FTUs huggingface dataset:
A comparison of stigma toward eating disorders versus depression.

OBJECTIVE The goal of this study was to compare the degree of stigma associated with anorexia nervosa (AN), bulimia nervosa (BN), and depression. METHOD Participants read one of three vignettes describing clinical cases of AN, BN, or depression, and answered questions assessing stigma toward individuals with one of these three mental disorders. RESULTS Attitudes toward individuals with eating disorders were significantly more stigmatizing than attitudes toward individuals with depression. Individuals with an eating disorder were rated as more fragile, more responsible for their disorder, and more likely to use their disorder to gain attention than individuals with depression. Furthermore, the majority of participants reported that they admired certain aspects of eating disorders, thought that there might be some benefits to having an eating disorder, and that others would be motivated to imitate eating disorder behavior. DISCUSSION Stigma toward individuals with eating disorders is greater than stigma toward depression and includes unique features such as attitudes of envy. Implications of these results for the understanding of mental disorder stigma and eating disorders are discussed.
Syk Tyrosine Kinase Mediates Epstein-Barr Virus Latent Membrane Protein 2A-induced Cell Migration in Epithelial Cells*

Although spleen tyrosine kinase (Syk) is known to be important in hematopoietic cell development, the roles of Syk in epithelial cells have not been well studied. Limited data suggest that Syk plays alternate roles in carcinogenesis under different circumstances. In breast cancer, Syk has been suggested to be a tumor suppressor. In contrast, Syk is essential for murine mammary tumor virus-mediated transformation. However, the roles of Syk in tumor migration are still largely unknown. Nasopharyngeal carcinoma, an unusually highly metastatic tumor, expresses Epstein-Barr virus LMP2A (latent membrane protein 2A) in most clinical specimens. Previously, we demonstrated LMP2A triggers epithelial cell migration. LMP2A contains an immunoreceptor tyrosine-based activation motif, which is important for Syk kinase activation in B cells. In this study, we explored whether Syk is important for LMP2A-mediated epithelial cell migration. We demonstrate that LMP2A expression can activate endogenous Syk activity. The activation requires the tyrosine residues in LMP2A ITAM but not YEEA motif, which is important for Syk activation by Lyn in B cells. LMP2A interacts with Syk as demonstrated by coimmunoprecipitation and confocal microscopy. Furthermore, LMP2A-induced cell migration is inhibited by a Syk inhibitor and short interfering RNA. Tyrosines 74 and 85 in the LMP2A immunoreceptor tyrosine-based activation motif are essential for both Syk activation and LMP2A-mediated cell migration, indicating the involvement of Syk in LMP2A-triggered cell migration. The LMP2A-Syk pathway may provide suitable drug targets for treatment of nasopharyngeal carcinoma.
Interactive Effects of Cadmium and Zinc Application on Their Uptake by Rice Under Waterlogged and Non-waterlogged Conditions

In order to investigate the effect of Cd and Zn on uptake, concentration and the translocation factor of the Cd and Zn in the rice plant, a factorial experiment was conducted with four factors including two rice cultivars of Vandana and Hashemi, two waterlogged and non-waterlogged conditions and three levels of Zn and Cd (0, 5 and 10 mg kg -1 soil). The experiment was carried out in a randomized complete blocks design with three replications in the greenhouse conditions. According to the results, by changing water regime from waterlogged to non-waterlogged condition, the Zn concentration of root and shoot and the Cd concentration of root were decreased in Vandana cultivar but Cd concentration of shoot was increased and exceeded from the critical level. Zn application caused an increase in Zn and Cd content of shoot, but caused a decrease in Cd concentration of shoot and root. Cd application caused an increase at the first concentration and then decreased the Zn concentration of shoot and root. With increasing the level of Cd, the Cd concentration of shoot and root and the Zn concentration of root increased at the first concentration of Cd and then at decreased at the second level. By application of Cd in each Zn level, the translocation factor of Zn and Cd were decreased.
THE EFFECTS OF INTERNAL AND EXTERNAL MECHANISM ON GOVERNANCE AND PERFORMANCE OF CORPORATE FIRMS IN NIGERIA

There is a renewed interest on the need to strengthen mechanisms to ensure that managers and directors take measures to protect the interest of a firm’s stakeholders. This study made use of panel data regression analysis between 2002 and 2006 for a sample of 62 firms listed on the Nigerian Stock Exchange to examine the relationship between internal and external governance mechanisms and corporate firms’ performance. The results have the implication that regulatory agencies should encourage firms to achieve a reasonable board size since overly large boards may be detrimental to the firm. Our results also show no significant evidence to support the idea that outside directors help promote firm performance. In addition, the study found that the measure of performance matter for analysis of corporate governance studies. We found in some cases different results from the use of Returns on Assets (ROA) and Tobin’s Q as measures of firm performance.
Congenital immunodeficiency in an individual with Wiedemann–Steiner syndrome due to a novel missense mutation in KMT2A

Wiedemann–Steiner Syndrome (WSS) is an autosomal dominant disorder characterized by hypertrichosis, short stature, intellectual disability, developmental delay, and facial dysmorphism. Since the original reports by Wiedemann and co‐workers, and Steiner and Marques, only a few cases have been described. Recently, the clinical variability of the disorder has more precisely been characterized by Jones and co‐workers, who also identified heterozygous KMT2A mutations as the molecular defect underlying this condition. Here, we report on a boy with a complex phenotype overlapping WSS but exhibiting epilepsy, feeding difficulties, microcephaly, and congenital immunodeficiency with low levels of immunoglobulins as additional features. Whole exome sequencing allowed identifying a previously unreported de novo KMT2A missense mutation affecting the DNA binding domain of the methyltransferase. This finding expands the clinical phenotype associated with KMT2A mutations to include immunodeficiency and epilepsy as clinically relevant features for this disorder. © 2016 Wiley Periodicals, Inc.
Gender and Poverty Reduction: A Kenyan Context.

Poverty is a dehumanising condition for every one. It erodes human rights of the affected whether women or men. Poverty subjects an individual to a state of powerlessness, hopelessness, and lack of self-esteem, confidence, and integrity, leading to a situation of multidimensional vulnerability. Poverty has a gender dimension since women and men experience and react differently to its impact. It cuts across age, ethnicity and gender. Unless there are realistic and workable interventions to redress the situation, there develops a vicious circle of poverty where it is inherited from one generation to the other in households, communities and the nation. As many people in Kenya are poor with the women bearing the blunt of it, reducing its impact as well as breaking its vicious circle requires a concerted effort and a gender perspective in all the interventive strategies. Commitment of Kenya Government to eradicate poverty is manifest in its current development strategies, as demonstrated with the efforts towards the achievement of the Millennium Development Goals, especially No. 1, on the eradication of poverty to less than 30% of the Kenyans by 2015 and the Kenya Vision 2030. However, the reality on the ground indicates that despite these intentions, the increase on the number of the poor both in rural and urban Kenya has been worrying. This creates a need to intensify poverty reduction efforts in planning and programming, especially as regards to human resource development, health, employment, physical infrastructures, agriculture, rural development, trade, public safety, law and order, all of which are instrumental in scaling up the development process and poverty eradication. Moreover sustainable poverty reduction strategies must engage both women and men as actors and beneficiaries. Key words: Kenya, poverty, gender, development, strategies.
Pregnancy-Specific Down-Regulation of NF-κB Expression in T Cells in Humans Is Essential for the Maintenance of the Cytokine Profile Required for Pregnancy Success1

It is accepted that human pregnancy is associated with a shift away from Th1 type and a bias toward Th2-type immune responses. The molecular mechanisms that regulate this shift are as yet unknown. We assessed the expression and activity of NF-κB, a transcription factor that plays a central role in regulating immune responses. We isolated T cells from PBMCs from nonpregnant and pregnant females and demonstrated that the NF-κB/IκB signaling pathway is down-regulated in T cells in pregnancy. Using Western blotting, high levels of NF-κB (p65) were detected in all nuclear fractions of T cells from nonpregnant females. In contrast, low levels of p65 were detected in nuclear fractions from T cells from pregnant females. Levels of IκBα and -β were also higher in cytoplasmic fractions from T cells from nonpregnant than from pregnant females. The reduction in p65 levels in pregnancy was reflected in the activity of NF-κB in EMSA; T cells from pregnant females contain less active NF-κB than from nonpregnant females. Stimulation of T cells from nonpregnant females with PMA/ionomycin resulted in IκBα degradation, p65 translocation, and subsequent production of the Th1 cytokines IFN-γ and IL-2. In contrast, PMA stimulation had no effect on NF-κB activity in T cells from pregnant females, and this was reflected in reduced Th1 cytokine production. Using the inhibitor of NF-κB activity, SN50, we were able to show that NF-κB activity was essential for the production of Th1 cytokines, suggesting that specific down-regulation of NF-κB in T cells throughout gestation is paramount to pregnancy success through specific regulation of cytokine production.
Unilocular radiolucencies of anterior mandible in young patients: A 10 year retrospective study

Introduction: Mandibular anterior region is an uncommon site for occurrence of intrabony pathologies. Unilocular presentation of a lesion is again less common than multilocular appearance. Demographically, most lesions occur in middle to elderly age group. The study is designed to review the pathologies manifesting a combination of these rare demographic and radiological criteria. Materials and Methods: A retrospective analysis of patients with anterior unilocular radiolucencies of mandible in young patients was done. Records of past 10 years were searched. There were a total of 17 patients. Their clinical history and radiographs were reviewed from the case files and correlated with histopathological examination of the lesion. Results: Nine different pathologies constituted the sample size of 17. A wide array of lesions was found to manifest similar signs and symptoms and radiographic findings namely ameloblastoma (three), adenomatoid odontogenic tumor (AOT, four), odontogenic keratocyst (OKC, three), ossifying fibroma (OF, two), idiopathic bone cavity (IBC, one), dentigerous cyst (DC, one), radicular cyst (RC, one), central giant cell granuloma (CGCG, one), and calcifying odontogenic cyst (COC, one). Conclusion: Anterior mandible is a rare site for occurrence of intrabony pathologies. Majority of patients are females. Lesions acquire large size before they are detected. Growth occurs more in length than in width. Root resorption is not uncommon and root displacement is almost a consistent feature.
A Comparison of Students' Perceptions of Stress in Parallel Problem-Based and Lecture-Based Curricula

Purpose A 6-year longitudinal study was conducted to compare the perceived stress experienced during a 2-year master's physician assistant program by 5 cohorts of students enrolled in either problem-based learning (PBL) or lecture-based learning (LBL) curricular tracks. The association of perceived stress with academic achievement was also assessed. Methods Students rated their stress levels on visual analog scales in relation to family obligations, financial concerns, schoolwork, and relocation and overall on 6 occasions throughout the program. A mixed model analysis of variance examined the students' perceived level of stress by curriculum and over time. Regression analysis further examined school work-related stress after controlling for other stressors and possible lag effect of stress from the previous time point. Results Students reported that overall stress increased throughout the didactic year followed by a decline in the clinical year with statistically significant curricular (PBL versus LBL) and time differences. PBL students also reported significantly more stress resulting from school work than LBL students at some time points. Moreover, when the other measured stressors and possible lag effects were controlled, significant differences between PBL and LBL students' perceived stress related to school work persisted at the 8- and 12-month measurement points. Increased stress in both curricula was associated with higher achievement in overall and individual organ system examination scores. Conclusion Physician assistant programs that embrace a PBL pedagogy to prepare students to think clinically may need to provide students with additional support through the didactic curriculum.
Role of glucagon in the metabolic response to stress in chickens.

P. MONEVA, D. GUDEV, S. POPOVA-RALCHEVA, D. ABADJIEVA and I. YANCHEV, 2010. Role of glucagon in the metabolic response to stress in chickens. Bulg. J. Agric. Sci., 16: 91-98 Forty Lohmann breed chickens at seven weeks of age were housed in cages (5 per cage) . The chickens were divided into 3 groups: I - control group injected with saline solution (0.9% NaCl), II group - injected with gluca- gon (50 μg /bird) and III group - injected with glucagon (100 μg/bird) into the breast muscle. Blood samples were taken at the following intervals: 0 min (baseline level), 30, 60, 90 and 120 min following the injection in I and II group, and 30 and 90 min following the injection in III group. Exogenous glucagon potentiated handling-induced corticosterone enhancement. There was no relationship between plasma corticosterone and glucose level in glucagon treated chickens. Plasma cholesterol level declined during the first 60 min following the administration of glucagon and then increased during the next 60 min (60-120 min) in the chickens given 50 μg glucagon while in the chickens given 100 μg glucagon cholesterol level declined both by 30 and 90 min, relative to baseline level. The dynamics of heterophil-to-lymphocyte ratio did not correspond to plasma corticosterone level. Exogenous glucagon had no significant effect on hematocrit, erythrocyte and leukocyte numbers. These results suggest that exogenous glucagon stimulates adrenal function and exerts control on stress- induced increase in plasma glucose level, heterophil-to-lymphocyte ratio and plasma cholesterol level.
Sugarcane Response to Water-Deficit Stress during Early Growth on Organic and Sand Soils

Problem statement: Approximately 20% of sugarcane (Saccharum spp.) is grown on sand soils in south Florida, USA. Sugarcane yields in the region linearly increased in last 33 years on organic (muck) soils, but not on sand soils. Water deficit during the formative growth phase on sand soils probably limits sugarcane yields. Approach: A greenhouse study was conducted in 2009 and 2010 to evaluate the physiological and growth responses of sugarcane to water-deficit stress during formative growth. Treatments included organic (muck) and sand soils and two water regimes Well Watered (WW) and Water-Deficit Stress (WS). Sugarcane cultivar CP 80-1743 was planted in pots and fertilized with N, P and K based on soil analyses. All pots were well watered until 58 days after planting, when water was withheld from the WS pots. During the WS treatment, plant growth rate, leaf Relative Water Content (RWC), proline content and photosynthesis components were measured. Final tillers, Green Leaf Area (GLA) and shoot biomass were determined 27 (in 2009) or 22 (in 2010) days after initiating the WS treatment. Results: Stress symptoms of sugarcane plants appeared 7-10 days earlier on sand soil than on muck soil. Water stress reduced stomatal conductance (gs), Photosystem II Photochemical Efficiency (ΦPSII), leaf Photosynthesis rate (Pn), the number of tillers and GLA, resulting in reduced shoot biomass, especially on sand soil. Neither leaf RWC nor proline content was a sensitive WS indicator. Conclusion: Nondestructive measurements of physiological traits of gs, ΦPSII and Pn during the formative stage may be useful for early detection of water stress in sugarcane.
Cyclic nucleotide concentrations in tissue and perfusate of isolated rat lung.

Cyclic nucleotide content of lung tissue is altered by anesthesia, ventilatory pattern, and pharmacologic manipulation (e.g., isoproterenol). In addition the lung releases cyclic nucleotides into its circulation, but little is known about factors that might alter this release. We isolated and perfused rat lungs (IPL) to determine: 1) if cyclic nucleotides are released into the perfusate in the control state; and 2) if their release changes after alteration of the ventilatory pattern or the addition of isoproterenol. We demonstrated that the rat IPL releases both cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) into the perfusate. Isoproterenol has no effect on cGMP release but increases cAMP release dramatically. Perfusate cAMP is not affected by ventilatory pattern, but perfusate cGMP is higher during high-pressure ventilation than it is in nonventilated or normally ventilated lungs.
Classical swine fever in wild boar in the Lombardy region of Italy from 1997 to 2002

In 1997, outbreaks of classical swine fever occurred in wild boar and domestic pigs in the Italian province of Varese (Lombardy region). Statutory animal health measures were imposed, and a control plan aimed at preventing the virus from spreading outside the infected hunting zone of 108 km2 was implemented. However, in 1998, virologically positive wild boar were found outside this zone, including within Swiss territory. The infected zone was then enlarged to include the three other hunting areas of the northern province of Varese and the neighbouring Swiss territory. Italian and Swiss veterinary services initiated a joint policy to control the disease by hunting young wild boar and conserving older, immune animals. The percentage of virologically positive animals gradually decreased, the last being found in July 2000. The seroprevalence initially increased, but in 2000 and 2001 it decreased from 42.2 per cent to 8.8 per cent, indicating that the wild boar population had had no further contact with the virus.
mTOR complex 1: a key player in neuroadaptations induced by drugs of abuse

The mammalian (or mechanistic) target of rapamycin (mTOR) complex 1 (mTORC1) is a serine and threonine kinase that regulates cell growth, survival, and proliferation. mTORC1 is a master controller of the translation of a subset of mRNAs. In the central nervous system mTORC1 plays a crucial role in mechanisms underlying learning and memory by controlling synaptic protein synthesis. Here, we review recent evidence suggesting that the mTORC1 signaling pathway promotes neuroadaptations following exposure to a diverse group of drugs of abuse including stimulants, cannabinoids, opiates, and alcohol. We further describe potential molecular mechanisms by which drug‐induced mTORC1 activation may alter brain functions. Finally, we propose that mTORC1 is a focal point shared by drugs of abuse to mediate drug‐related behaviors such as reward seeking and excessive drug intake, and offer future directions to decipher the contribution of the kinase to mechanisms underlying addiction.
Random Number Generation in Patients with Symptomatic and Presymptomatic Huntington's Disease

Random number generation (RNG), which involves producing lists of numbers at random, requires response selection and inhibition, which are aspects of executive function mediated by the frontal lobe. This study examined RNG performance in a group of mild to moderate Huntington's disease (HD) patients, asymptomatic gene-positive HD patients, and controls. The HD symptomatic group was significantly less random in their choices than controls. The gene-positive asymptomatic HD patients also showed a tendency toward abnormal RNG measures compared with controls, although this did not reach statistical significance after correction for multiple comparisons. However, analyzing the HD group as a whole showed that the frequency of errors, preferential selection of favorite numbers, and counting in 1's correlated significantly with the degree of symptom severity. Furthermore, counting in 1's correlated with degree of vulnerability to symptoms. A subset of patients and controls were retested 6 months later, and all RNG measures showed high correlations over time, highlighting the robust reliability of this test. The data therefore suggest that RNG is a useful, brief and reliable test of executive function and may be of value in studies investigating the longitudinal effects of disease-modifying treatment in HD.
Utah State University From the SelectedWorks of Terry A . Messmer 2016 Evaluating Vital Rate Contributions to Greater Sage-grouse Population Dynamics to Inform Conservation

Species conservation efforts often use shortterm studies that fail to identify the vital rates that contribute most to population growth. Although the greater sagegrouse (Centrocercus urophasianus; sagegrouse) is a candidate for protection under the U.S. Endangered Species Act, and is sometimes referred to as an umbrella species in the sagebrush (Artemisia spp.) biome of western North America, the failure of proposed management strategies to focus on key vital rates that may contribute most to achieving population stability remains problematic for sustainable conservation. To address this dilemma, we performed both prospective and retrospective perturbation analyses of a life cycle model based on a 12yr study that encompassed nearly all sagegrouse vital rates. To validate our population models, we compared estimates of annual finite population growth rates (λ) from our femalebased life cycle models to those attained from malebased lek counts. Postfledging (i.e., after second year, second year, and juvenile) female survival parameters contributed most to past variation in λ during our study and had the greatest potential to change λ in the future, indicating these vital rates as important determinants of sagegrouse population dynamics. In addition, annual estimates of λ from femalebased life cycle models and malebased lek data were similar, providing the most rigorous evidence to date that lek counts of males can serve as a valid index of sagegrouse population change. Our comparison of fixed and mixed statistical models for evaluating temporal variation in nest survival and initiation suggest that conservation planners use caution when evaluating shortterm nesting studies and using associated fixedeffect results to develop conservation objectives. In addition, our findings indicated that greater attention should be paid to those factors affecting sagegrouse postfledging females. Our approach demonstrates the need for more longterm studies of species vital rates across the life cycle. Such studies should address the decoupling of sampling variation from underlying process (co)variation in vital rates, identification of how such variation drives population dynamics, and how decision makers can use this information to redirect conservation efforts to address the most limiting points in the life cycle for a given population.