Miracle-dz/UniFAR-FTUs huggingface dataset:
Lactobacillus acidophilus Alleviated Salmonella‐Induced Goblet Cells Loss and Colitis by Notch Pathway

SCOPE The intestinal mucosal barrier, including the mucus layer, protects against invasion of enteropathogens, thereby inhibiting infection. In this study, the protective effect of Lactobacillus on the intestinal barrier against Salmonella infection is investigated. The underlying mechanism of its effect, specifically on the regulation of goblet cells through the Notch pathway, is also elucidated. METHODS AND RESULTS Here, the protective effect of Lactobacillus on alleviating changes in the intestinal barrier caused by Salmonella infection is explored. It has been found that Salmonella typhimurium colonizes the colon and damages colonic mucosa. However, Lactobacillus acidophilus ATCC 4356 alleviates the colitis caused by Salmonella infection. Moreover, S. typhimurium infection causes colonic crypt hyperplasia with increased PCNA+ cells, while L. acidophilus administration resolves these pathological changes. In addition, it has been further demonstrated that Salmonella results in severe colitis associated with goblet cells, and Lactobacillus improves colitis similarly associated with goblet cells. Salmonella infection induces goblet cell loss and reduces MUC2 expression by increasing Dll1, Dll4, and HES1 expression, while L. acidophilus reverses epithelial damage by balancing the Notch pathway. CONCLUSION The study demonstrates that colitis improvement is controlled by Lactobacillus ATCC 4356 by regulation of the Notch pathway; this finding will be useful for prevention against animal S. typhimurium infection.
Exploiting local and global performance of candidate systems for aggregation of summarization techniques

With an ever growing number of extractive summarization techniques being proposed, there is less clarity then ever about how good each system is compared to the rest. Several studies highlight the variance in performance of these systems with change in datasets or even across documents within the same corpus. An effective way to counter this variance and to make the systems more robust could be to use inputs from multiple systems when generating a summary. In the present work, we define a novel way of creating such ensemble by exploiting similarity between the content of candidate summaries to estimate their reliability. We define GlobalRank which captures the performance of a candidate system on an overall corpus and LocalRank which estimates its performance on a given document cluster. We then use these two scores to assign a weight to each individual systems, which is then used to generate the new aggregate ranking. Experiments on DUC2003 and DUC 2004 datasets show a significant improvement in terms of ROUGE score, over existing sate-of-art techniques.
The neutrophil-to-lymphocyte ratio and mean platelet volume can be associated with severity of valvular involvement in patients with acute rheumatic carditis.

OBJECTIVE The aim of the study was to investigate the association between the severity of acute rheumatic carditis (ARC) and the neutrophil-lymphocyte ratio (NLR) and mean platelet volume (MPV). METHODS Paediatric patients diagnosed with ARC between 2010 and 2016 and age- and gender-matched controls were retrospectively analysed. At the time of diagnosis, we reviewed the demographic features obtained: echocardiographic data, complete blood count reports, acute-phase reactants, including C-reactive protein, and erythrocyte sedimentation rate values. The patient group was further divided into two subgroups according to the degree of valvular regurgitation, which included those with severe and those with mild-to-moderate valvular regurgitation. RESULTS The number of cases with ARC and age- and gender-matched controls were 120 and 50, respectively. The mean age of the patients was 12.25 ± 2.89 (range: 7-18) years. NLR, MPV, anti-streptolysin-O, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), haemoglobin level, and white blood cell (WBC) and neutrophil count were significantly higher in patients with acute carditis compared with the controls (p < 0.001). NLR was found to have a significantly positive correlation with CRP (r = 0.177, p = 0.001), ESR (r = 0.81, p = 0.03) and WBC count ( r = 0.47, p = 0.001). Moreover, we found a positive correlation between NLR and severity of valvular regurgitation (r = 0.34, p < 0.001), and a negative correlation between MPV and severity of valvular regurgitation ( r = -0.38, p < 0.05) in our patients. In multiple linear regression analysis, severe valvular regurgitation was associated with NLR (0.51; 95% CI: 0.32-0.68; p = 0.006) and MPV ( -0.78; 95% CI: -0.72 to -0.98; p = 0.008). CONCLUSIONS NLR and MPV are novel inflammatory markers and simple, rapid and easily accessible prognostic parameters that can be associated with severity of valvular involvement in patients with ARC.
Efficacy and Safety of Budesonide, vs Mesalazine or Placebo, as Induction Therapy for Lymphocytic Colitis.

BACKGROUND & AIMS Lymphocytic colitis is a common cause of chronic, nonbloody diarrhea. However, the effects of treatment are unclear and randomized placebo-controlled trials were requested in a Cochrane review. We performed a randomized, placebo-controlled, multicenter study to evaluate budesonide and mesalazine as induction therapy for lymphocytic colitis. METHODS Patients with active lymphocytic colitis were randomly assigned to groups given budesonide 9 mg once daily (Budenofalk granules), mesalazine 3 g once daily (Salofalk granules), or placebo for 8 weeks in a double-blind, double-dummy design. The primary endpoint was clinical remission, defined as ≤21 stools (including ≤6 watery stools), in the 7 days before week 8. RESULTS The final analysis included 57 patients (19 per group). Most patients were female (72%) and the mean age was 59 years. The proportion of patients in clinical remission at week 8 was significantly higher in the budesonide group than in the placebo group (intention-to-treat analysis, 79% vs 42%; P = .01). The difference in proportions of patients in clinical remission at week 8 between the mesalazine (63%) and placebo groups was not significant (P = .09). The proportion of patients with histologic remission at week 8 was significantly higher in the budesonide group (68%) vs the mesalazine (26%; P = .02) or placebo (21%; P = .008) groups. The incidence of adverse events was 47.4% in the budesonide group, 68.4% in the mesalazine group, and 42.1% in the placebo group. CONCLUSIONS In a randomized multicenter study, we found oral budesonide 9 mg once daily to be effective and safe for induction of clinical and histologic remission in patients with lymphocytic colitis, compared with placebo. Oral mesalazine 3 g once daily was not significantly better than placebo. ClinicalTrials.gov no: NCT01209208.
Phytoremediation of waste dumping site soil and landfill leachate by using cattail (Typha latifolia)

ABSTRACT In this study, cattail (Typha latifolia) was used to remove Na+ and Cl− from polluted soil (PS) in a solid waste open dumping site. Hydroponic system was also evaluated to remove Na+ and Cl− from landfill leachate. The results indicated that the cattail grown in PS had higher biomass yield of 44.4 ± 3.29 g compared to that of control (35.3 ± 4.28 g). Nitrogen and phosphorous contents of cattails grown in PS were also higher than that of control plants, and the electrical conductivity of PS significantly decreased from 245 ± 1.40 to 51.9 ± 9.30 ms/m over the 5-week experimental duration. Na+ and Cl− contents from cattail grown on PS were 10.8 ± 1.85 and 64.7 ± 9.15 g/kg biomass, respectively. For cattails grown hydroponically in water containing leachate, nitrogen and phosphorous accumulation was 51.1 ± 5.94 and 9.32 ± 3.22 g/kg biomass, respectively. The corresponding biomass yield of these cattails was 13.5 ± 1.29 g at the end of 5 weeks. In addition, the Na+ and Cl− accumulation of 55.5 ± 4.82 and 78.2 ± 28.3 g/Kg biomass, respectively, was higher in hydroponic cattails grown in this study. Overall, the results suggest the effectiveness of cattails for phytoremediation of contaminated soil and the high efficiency of hydroponic system for nutrient and salinity removal compared to the conventional soil test. GRAPHICAL ABSTRACT
Neuronal underpinnings of cognitive impairment and - improvement in mood disorders

Neuropsychiatric illnesses including mood disorders are accompanied by cognitive impairment, which impairs work capacity and quality of life. However, there is a lack of treatment options that would lead to solid and lasting improvement of cognition. This is partially due to the absence of valid and reliable neurocircuitry-based biomarkers for pro-cognitive effects. This systematic review therefore examined the most consistent neural underpinnings of cognitive impairment and cognitive improvement in unipolar and bipolar disorders. We identified 100 studies of the neuronal underpinnings of working memory and executive skills, learning and memory, attention, and implicit learning and 9 studies of the neuronal basis for cognitive improvements. Impairments across several cognitive domains were consistently accompanied by abnormal activity in dorsal prefrontal (PFC) cognitive control regions—with the direction of this activity depending on patients’ performance levels—and failure to suppress default mode network (DMN) activity. Candidate cognition treatments seemed to enhance task-related dorsal PFC and temporo-parietal activity when performance increases were observed, and to reduce their activity when performance levels were unchanged. These treatments also attenuated DMN hyper-activity. In contrast, nonspecific cognitive improvement following symptom reduction was typically accompanied by decreased limbic reactivity and reversal of pre-treatment fronto-parietal hyper-activity. Together, the findings highlight some common neural correlates of cognitive impairments and cognitive improvements. Based on this evidence, studies are warranted to examine the reliability and predictive validity of target engagement in the identified neurocircuitries as a biomarker model of pro-cognitive effects.
A review of factors influencing radiologists’ visual search behaviour

This narrative literature review aims to identify the various factors that have significant impact on radiologists’ visual search patterns. Identifying the factors that influences readers’ visual search behaviour helps to understand their perception and interpretation of medical images, which in turn could lead to the development and implementation of effective strategies that could aid in improving the ability to detect abnormalities. Databases including PubMed, MedLine, Web of Science and ScienceDirect were searched using terms ‘visual search’, ‘eye‐tracking’, ‘radiology OR radiography’, ‘mammogram OR mammography’ published since the early 1960s until June 30, 2016. Some of the factors that have been identified to significantly influence radiologists’ visual search patterns were (i) readers’ expertise, (ii) Satisfaction of Search, (iii) readers’ visual fatigue, (iv) readers’ confidence in reporting abnormalities, (v) training received and (vi) readers’ prior knowledge. Readers’ level of expertise was the factor that has been identified to have the most significant impact on their visual search pattern. Eye‐tracking studies have shown the differences in visual search patterns of readers with different levels of experience and not so surprisingly, more experienced readers have shown effective visual search strategies. Readers’ expertise has also been found to have significant impact in their confidence in reporting abnormalities and their ability to discriminate lesions from background structures in medical images.
Optimization of siRNA delivery to target sites: issues and future directions

ABSTRACT Introduction: The discovery of RNA interference (RNAi) earned the 2006 Nobel Prize in Physiology or Medicine for its biological significance and potential for developing novel therapeutics. The small interfering RNA (siRNA) is the most promising tool for translating RNAi to clinical use. Efforts are ongoing to improve siRNA delivery through developing novel biomaterials and delivery strategies. Given time, it appears that siRNA drugs will eventually become a reality. Areas covered: The currently used approaches for siRNA delivery are discussed with a focus on siRNA therapeutics currently in clinical testing. A comparison of advantageous aspects of currently available platforms and the possibility of further optimization for increased efficiency and safety are presented. Future directions in siRNA delivery are also highlighted. Expert opinion: The recent success in the field of siRNA delivery is based mainly on developing new biomaterials with extraordinarily high activities. Notably, the introduction of ionizable lipids and novel targeting ligands represent two huge steps for realizing siRNA therapy. The currently available systems are largely directed to the liver and the new challenge is to extend their applicability for treating diseases of other organs. Active targeting to different organs is the most promising approach for developing new siRNA-based therapeutics.
Gamma irradiation of clove: level of trapped radicals and effects on bioactive composition.

BACKGROUND Food irradiation is a widely used technique for improving the safety and shelf life of foods, including most spices. However, growing concerns by consumers about this technique require further investigation on the effects of radiation, both on the safety of the food and on its organoleptic properties. In this work, cloves of diverse origins were submitted to different irradiation doses in a 60 Co source. The presence of trapped radicals and their time-dependent decay after irradiation were assessed by electron spin resonance (ESR) spectroscopy. The volatile bioactive composition and the clove oil were evaluated before and after irradiation by gas chromatography time-of-flight mass spectrometry. RESULTS Results show an increase of the amount of volatiles collected after irradiation, especially of caryophyllene oxide and acetic acid, although these are still minor constituents. No new compound was detected after irradiation. Radicals decay fast, and 60 days after irradiation they were undetectable by ESR. CONCLUSION Gamma irradiation showed to be a clean technique for clove decontamination, since no significant change in the aroma or oil compositions was found, and low levels of trapped paramagnetic species, after the initial decay period, were detected upon irradiation. Furthermore, irradiation doses higher than those legally allowed are equally safe. © 2018 Society of Chemical Industry.
Long-Term Changes in Straylight Induced by Overnight Orthokeratology: An Objective Measure Using the Double-Pass System

ABSTRACT Purpose: To map the time course of changes in intraocular straylight of the human eye 1 year after initial lens wearing for orthokeratology treatment using the objective double-pass technique. Materials and Methods: A total of 35 subjects (19 males and 16 females) completed the study. The mean age was 11.46 ± 2.33 years (range, 8–16 years). All subjects were fitted with spherical four-zone orthokeratology lenses following the procedures recommended by the lens manufacturer. The subjects were required to wear the lens for at least eight consecutive hours at night. After lens removal during the daytime, objective scattering index (OSI) was evaluated using the double-pass technique (OQAS-II, Visiometrics, Terrassa, Spain) prior to lens dispatch (baseline), followed by evaluations at 1 week, 1 month, 6 months, and 12 months after the initial lens wearing. Longitudinal changes were fitted to a model containing both an impairing and recovery component, and the results were based on an extrapolation between the visits. Results: OSI rose quickly following lens wearing, reaching its highest level (double that of baseline values) by approximately 1.47 months. However, the recovery phase was slow and modest. One year after the initial lens wearing, OSI exhibited a 20% recovery from the peak level, but remained 63% higher than the baseline level. Conclusions: Intraocular straylight immediately increased flowing lens wearing, and this change reaches maximal level around 1 month after lens wearing. Slow but significant recoveries of optical quality subsequently followed.
Conflict management among health professionals in hospitals of Cyprus

AIM To record the types of conflict management that health professionals in Cyprus hospitals encounter in their daily work and to explore the conflicts, their parameters and causes, and the role ambiguity faced by the hospital employees. MATERIAL AND METHODS This is a descriptive study in which data were collected with an anonymous self-referral questionnaire. The study population consisted of 300 health professionals from six different hospitals in Cyprus. Data are presented with averages and standard deviations. RESULTS The health professionals identified the following causes of conflicts in the workplace in descending order: heavy workload, low pay, and varying instructions from different leaders. To deal with the conflict, 73.2% of the participants reported using avoidance, 54.2% engaged in negotiation for mutual benefit, and 40.5% cited compromise as a method. CONCLUSIONS Identifying the way in which conflicts are managed contributes to the smooth functioning of organisations, and it improves the effectiveness of the services provided. IMPLICATIONS FOR NURSING MANAGEMENT It is generally known that the high levels of conflict in hospitals are associated with increased mistakes and low employee satisfaction and performance levels. Managers deal with conflict-management issues within organisations on a daily basis. It is therefore essential to comprehend the reasons behind conflicts and provide suitable training for the development of communication skills and conflict-management strategies.
Dicarbonyl Stress and Glyoxalase-1 in Skeletal Muscle: Implications for Insulin Resistance and Type 2 Diabetes

Glyoxalase-1 (GLO1) is a ubiquitously expressed cytosolic protein which plays a role in the natural maintenance of cellular health and is abundantly expressed in human skeletal muscle. A consequence of reduced GLO1 protein expression is cellular dicarbonyl stress, which is elevated in obesity, insulin resistance and type 2 diabetes (T2DM). Both in vitro and pre-clinical models suggest dicarbonyl stress per se induces insulin resistance and is prevented by GLO1 overexpression, implicating a potential role for GLO1 therapy in insulin resistance and type 2 diabetes (T2DM). Recent work has identified the therapeutic potential of novel natural agents as a GLO1 inducer, which resulted in improved whole-body metabolism in obese adults. Given skeletal muscle is a major contributor to whole-body glucose, lipid, and protein metabolism, such GLO1 inducers may act, in part, through mechanisms in skeletal muscle. Currently, investigations examining the specificity of dicarbonyl stress and GLO1 biology in human skeletal muscle are lacking. Recent work from our lab indicates that dysregulation of GLO1 in skeletal muscle may underlie human insulin resistance and that exercise training may impart therapeutic benefits. This minireview will summarize the existing human literature examining skeletal muscle GLO1 and highlight the emerging therapeutic concepts for GLO1 gain-of-function in conditions such as insulin resistance and cardiometabolic disease.
Effect of non‐compliant balloon postdilatation on magnesium‐based bioresorbable vascular scaffolds

Optimal implantation results of bioresorbable scaffolds (BRS) are typically assumed to require postdilatation with non‐compliant (NC) balloons to achieve full scaffold apposition and minimize event rates. We systematically evaluated the mechanical effect of NC balloon postdilatation on magnesium‐based BRS (Magmaris®, Biotronik AG, Bülach, Switzerland) in vivo.
Prognostic factors and primary treatment for Waldenström macroglobulinemia – a Swedish Lymphoma Registry study

We present a nationwide prospective Swedish registry‐based study of Waldenström macroglobulinaemia (WM), that focuses on incidence and survival in relation to clinical prognostic factors and primary systemic therapies. A total of 1511 patients with WM and lymphoplasmocytic lymphoma (LPL) were registered in the Swedish Lymphoma Registry (SLR) between 1 January 2000 and 31 December 2014. The age‐adjusted incidence of WM/LPL was 11·5 per million persons per year, three times higher than the reported incidence worldwide. Medical records were retrieved for 1135 patients (75%). A retrospective review showed that 981 (86·1%) of these patients fulfilled the World Health Organization diagnostic criteria for WM and these patients were analysed further. The overall survival (OS) improved between two periods – 2000–2006 and 2007–2014 – with a five‐year OS of 61% and 70%, respectively. Significant prognostic factors for OS, evaluated at the time of diagnosis, were age, elevated lactate dehydrogenase level and haemoglobin ≤115 g/l for patients receiving therapy 0–3 months after diagnosis, and age, poor performance status, haemoglobin ≤115 g/l, and female sex in “watch and wait” patients (multivariable analysis). The level of the IgM monoclonal immunoglobulin had no significant prognostic value. Rituximab included in first‐line therapy was associated with improved survival.
Transient-Evoked Otoacoustic Emissions Reflect Audiometric Patterns of Age-Related Hearing Loss

Distinct forms of age-related hearing loss are hypothesized based on evidence from animal models of aging, which are identifiable in human audiograms. The Sensory phenotype results from damage (e.g., excessive noise or ototoxic drugs) to outer hair cells and sometimes inner hair cells, producing large threshold increases predominately at high frequencies. The Metabolic phenotype results from a decline in endocochlear potential that can reduce outer hair cell motility throughout the cochlea, producing gradually sloping thresholds from lower to higher frequencies. Finally, the combined Metabolic + Sensory phenotype results in low-frequency losses similar to the Metabolic phenotype and high-frequency losses similar to the Sensory phenotype. Because outer hair cell function appears to be affected differently in each phenotype, this study used audiograms from 618 adults aged 50 to 93 years (n = 1,208 ears) to classify phenotypes and characterize differences in transient-evoked otoacoustic emission (TEOAE) data. Significant phenotype differences were observed in frequency-band TEOAEs and configuration (intercept and slope), including large and broadly distributed TEOAE reductions for Metabolic and Metabolic + Sensory ears and more focused high-frequency TEOAE reductions for Sensory ears. These findings are consistent with metabolic declines that reduce cochlear amplification across a broad range of frequencies and more basally situated, high-frequency declines in sensory hearing loss. The results provide further validation for the classification of age-related hearing loss phenotypes based on audiograms and show human TEOAE declines that are highly consistent with animal models.