Miracle-dz/UniFAR-FTUs huggingface dataset:
Fibrinogen and plasminogen activator inhibitor-1 level in peripheral arterial disease of type 2 diabetes patients.

AIM To determine association of fibrinogen and plasminogen activator inhibitor-1 with peripheral arterial disease (PAD) in type 2 diabetes patients. METHODS This is a cross-sectional study with 52 type 2 diabetes patients of 41-74 years old. The subjects were divided into two groups, those who were diagnosed with PAD (16) and without PAD (36). Diagnosis of PAD was based on the ankle brachial index (ABI) measurement. Fibrinogen and plasminogen activator inhibitor-1 (PAI-1) level were evaluated as hemostatic factors. The two groups were compared for age, sex, smoking, plasma fasting glucose, total cholesterol, low density lipoprotein (LDL), high density lipoprotein (HDL), triglyceride concentrations, diabetes duration, systolic blood pressure and diastolic blood pressure level. Statistical analyse were conducted to check the significance of differences between variables in the two groups as well as interrelationship between hemostatic factors and other parameters. RESULTS Fibrinogen was similar in both group (402.42 +/- 74.44 mg/dl in PAD group and 322.45 +/- 101.05 mg/dl in non-PAD group) (p= 0.259). PAI-1 was also similar in both group (8.93 +/- 11.02 IU/ml in PAD group and 7.06 +/- 7.32 IU/ml in non-PAD group) (p=0.721). Hyperfibrinogenemia was more prevalent in PAD group (68.8%) than in non-PAD group (25%) (p= 0.005). CONCLUSION Our data showed that fibrinogen and PAI-1 level were similar in both groups. As a risk factor hyperfibrinogenemia was more prevalent in PAD group.
Adolescent Feline Heart Contains a Population of Small, Proliferative Ventricular Myocytes With Immature Physiological Properties

Recent studies suggest that rather than being terminally differentiated, the adult heart is a self-renewing organ with the capacity to generate new myocytes from cardiac stem/progenitor cells (CS/PCs). This study examined the hypotheses that new myocytes are generated during adolescent growth, to increase myocyte number, and these newly formed myocytes are initially small, mononucleated, proliferation competent, and have immature properties. Ventricular myocytes (VMs) and cKit+ (stem cell receptor) CS/PCs were isolated from 11- and 22-week feline hearts. Bromodeoxyuridine incorporation (in vivo) and p16INK4a immunostaining were measured to assess myocyte cell cycle activity and senescence, respectively. Telomerase activity, contractions, Ca2+ transients, and electrophysiology were compared in small mononucleated (SMMs) and large binucleated (LBMs) myocytes. Heart mass increased by 101% during adolescent growth, but left ventricular myocyte volume only increased by 77%. Most VMs were binucleated (87% versus 12% mononucleated) and larger than mononucleated myocytes. A greater percentage of SMMs was bromodeoxyuridine positive (SMMs versus LBMs: 3.1% versus 0.8%; P<0.05), and p16INK4a negative and small myocytes had greater telomerase activity than large myocytes. Contractions and Ca2+ transients were prolonged in SMMs versus LBMs and Ca2+ release was disorganized in SMMs with reduced transient outward current and T-tubule density. The T-type Ca2+ current, usually seen in fetal/neonatal VMs, was found exclusively in SMMs and in myocytes derived from CS/PC. Myocyte number increases during adolescent cardiac growth. These new myocytes are initially small and functionally immature, with patterns of ion channel expression normally found in the fetal/neonatal period
Summary statistics of the dynamic PIN model and liquidity measures

Does informed trading affect emerging stock markets? Market microstructure literature establishes that information asymmetry reduces liquidity and moves prices in the direction of the trade. We test for this theoretical implication by running the dynamic PIN model of Easley, Engle, O’Hara y Wu (2008), for stocks of Argentina, Brazil, Chile, Colombia, Mexico and Peru. We use panel data models to test for the relation between PIN, as a measure of information asymmetry, bid-ask spreads, as a measure of liquidity, and returns. The reported results confirm the mentioned theoretical implications, the empirical validity dynamic PIN model, and contribute to a better understanding of price formation in emerging markets. JEL: G10, G15, G19
Sensitivity and specificity of the Geriatric Anxiety Inventory and the Hospital Anxiety and Depression Scale in the detection of anxiety disorders in older people with chronic obstructive pulmonary disease

ABSTRACT Background: Anxiety and depression are prevalent in patients with chronic obstructive pulmonary disease (COPD). This study evaluates the sensitivity and specificity of two self-administered anxiety rating scales in older people with COPD. The Geriatric Anxiety Inventory (GAI) and the Hospital Anxiety and Depression Scale (HADS) are established useful screening tools but they have not been previously validated in this population. Methods: Older people with COPD completed the GAI and the HADS along with a structured diagnostic psychiatric interview, the Mini International Neuropsychiatric Interview (MINI). The outcomes of both rating scales were compared against the diagnosis of anxiety disorders based on the MINI. Receiver operating characteristic (ROC) curves were used to identify the optimal diagnostic cut points for each scale. Results: Fourteen (25.5%) of the 55 participants, were diagnosed with an anxiety disorder. Mean GAI and HADS-anxiety subscale scores were significantly higher in subjects with an anxiety disorder than those without the diagnosis (p = 0.002 and 0.005 respectively). Both scales demonstrated moderate diagnostic value (area under the ROC curve was 0.83 for GAI and 0.79 for HADS). Optimal cut points were ≥3 (GAI) and ≥4 (HADS-anxiety subscale). At these cut-points, the GAI had a sensitivity of 85.7%, specificity of 78.0% and the HADS had a sensitivity of 78.6%, specificity 70.7%. Conclusion: Our results support the use of the GAI and HADS as screening instruments for anxiety disorders in older people with COPD. The optimal cut points in this population were lower than previously recommended for both rating scales. The results of this study should be replicated before these cut points can be recommended for general use in older people with COPD.
Systemic human orbital fat-derived stem/stromal cell transplantation ameliorates acute inflammation in lipopolysaccharide-induced acute lung injury

Objective:Acute lung injury results in acute respiratory distress syndrome. There is no standard therapy for acute respiratory distress syndrome but supportive care. Stem cells offer a new therapeutic potential for tissue regeneration as a result of their self-renewal, multipotency, and paracrine capabilities. The objective of this study is to investigate the effects and the mechanisms of systemic human orbital fat-derived stem/stromal cell transplantation on lipopolysaccharide-induced acute lung injury. Design:Prospective, randomized, controlled study. Setting:University-affiliated research institute. Subjects:Male BALB/c mice. Interventions:Twenty-five micrograms lipopolysaccharide in 50 &mgr;L sterile saline or 50 &mgr;L of sterile saline was delivered through intratracheal injection. Twenty mins later, the animals were further randomized into subgroups that received either a tail vein injection of 3 × 105 orbital fat-derived stem/stromal cells in 50 &mgr;L phosphate-buffered saline or 50 &mgr;L phosphate-buffered saline. Measurements and Main Results:Low immunogenicity and immune-tolerated of orbital fat-derived stem/stromal cells were observed in this xenotransplanted model. Orbital fat-derived stem/stromal cells significantly reduced lipopolysaccharide-induced pulmonary inflammation, which was evidenced by a decrease in total protein concentration and neutrophil counts in alveolar fluid through bronchoalveolar lavage, reduced endothelial and alveolar epithelial permeability as well as neutrophil (Ly6G-expressing cells) and macrophage (CD68-expressing cells) infiltration. Lipopolysaccharide-induced expression of CD14, inducible nitric oxide synthase, and transforming growth factor-&bgr; in lung tissue was significantly inhibited by orbital fat-derived stem/stromal cells. Orbital fat-derived stem/stromal cells not only reduced the circulation numbers of macrophages and neutrophils (CD11b-expressing cells), but also decreased systemic proinflammatory chemokine levels such as macrophage inflammatory protein-1-&ggr;, B-lymphocyte chemoattractant, interleukin-12, and subsequent circulation helper T cell (CD4-expressing cells) numbers. Furthermore, few human orbital fat-derived stem/stromal cells were detectable in the recipient lung after acute inflammation subsided. Conclusions:Systemic orbital fat-derived stem/stromal cell transplantation was effective in modulating inflammation during acute lung injury. The therapeutic effect was attributed to the inhibition of acute inflammatory responses. (Crit Care Med 2012; 40:–1253)
Development and validation of a method to directly measure the cable force during the hammer throw

The development of cable force during hammer-throw turns is crucial to the throw distance. In this paper, we present a method that is capable of measuring cable force in real time and, as it does not interfere with technique, it is capable of providing immediate feedback to coaches and athletes during training. A strain gauge was mounted on the wires of three hammers to measure the tension in the wire and an elite male hammer thrower executed three throws with each hammer. The output from the gauges was recorded by a data logger positioned on the lower back of the thrower. The throws were captured by three high-speed video cameras and the three-dimensional position of the hammer's head was determined by digitizing the images manually. The five best throws were analysed. The force acting on the hammer's head was calculated from Newton's second law of motion and this was compared with the force measured via the strain gauge. Qualitatively the time dependence of the two forces was essentially the same, although the measured force showed more detail in the troughs of the force–time curves. Quantitatively the average difference between the measured and calculated forces over the five throws was 76 N, which corresponds to a difference of 3.8% for a cable force of 2000 N.
Room to Relate in Centrelink? Attempts to Engage Supportively by Drawing on Guidance from Social Workers

Contact with the Australian social security and human service provider Centrelink offers opportunities for vital support, both financial and social. However, it can also invoke significant challenges, particularly where people struggle to relate and to make their voices heard. Centrelink has been criticised extensively as beset by machine-like bureaucratic processes, stigmatising ‘participation’ expectations, intrusive compliance interactions and a customer service framework inadequate for the serious needs of people seeking assistance. There has been extensive research attention to constrictive aspects of the Centrelink context. In keeping with this, interest in the small but significant body of social workers in Centrelink has largely focused on their struggles to maintain professional discretion and insulate themselves from challenging organisational surroundings. There has been less attention to alternative directions and organisational attempts to develop more freedom around relating in service situations despite recognition of the need for such. This dissertation addresses a gap in understanding by considering the relational challenge in Centrelink with reference to some alternative developments which have attempted to draw on social workers to guide service provision towards supportive relationships.
Virtual ontology, moral responsibility and agency : the ethical implications of mobile communication technology use on parenting style in Pietermaritzburg, South Africa.

ii Dedication . iii Acknowledgements . iv List of tables . xii List of figures . xii CHAPTER ONE: GENERAL INTRODUCTION TO THE STUDY . 1 1.0 Introduction . 1 1.1 Background . 2 1.2 Motivation for this study . 2 1.3 Research problem . 3 1.4 Key research questions . 3 1.5 Research objectives . 3 1.6 Preview of methodology . 4 1.7 Theoretical framework . 6 1.7. 1. Agency . 6 1.7. 2. Consequentialism . 7 1.7. 3 A Theory of Responsibility . 8 1.8 Significance of the study . 9 1.9 Structure of the study . 10 1.10 Conclusion . 11 CHAPTER TWO: THEORETICAL FRAMEWORK . 13 2.0 Introduction . 13 2.1 Agency . 13 2.1.1 Agency definition . 13 2.1.2. Types of agency . 14 2.1.2.1 Individual agency . 14 2.1.2.2 Agency and structure . 15 2.1.3 Argument for agency theory . 20 2.1.4 The critique of agency/structure . 21 2.1.5 How agency will be used to guide this research . 23 2.2 Consequentialism . 24 2.2.1 Definition of consequentialism . 24
Dental caries in Arab League countries: a systematic review and meta-analysis.

OBJECTIVE The aim of this review was to determine prevalence of dental caries in primary and permanent teeth in the 2-20-year-old population of the Arab league. METHODS A literature search was performed on Pubmed, Summon and Google Scholar using the key words 'Dental caries', 'dmft' and 'DMFT'. A total of 293 articles were found, of which 35 passed our inclusion criteria and were included in analysis. Tables were made separately for primary and permanent teeth; the age group for primary teeth was 2-12 years and for permanent teeth 6-20 years. RESULTS A meta-analysis was run by using data extracted from the studies included. Heterogeneity was tested by forest plot and chi-square test, and considerable heterogeneity was found. Mean decayed, missing and filled teeth (dmft) was 4.341 (95% CI 3.714, 4.969) and in permanent teeth (DMFT) was 2.469 (95% CI 2.019, 2.919) from a random effect model. Publication bias diagnostics suggested missing of four studies of primary teeth caries data and eight studies of permanent teeth caries data to obtain symmetry in the funnel plot. CONCLUSION The incidence of caries in primary teeth was found to be high compared with caries in permanent teeth in the Arab League. This study does not provide a comprehensive picture of caries prevalence in the Arab League because in many of these countries only a few studies were performed. Therefore, these data cannot provide a complete picture of the prevalence of caries in those countries. Additional studies are needed to better evaluate the prevalence of caries in children and young adults in Arab League countries.
A novel thermal sensor concept for flow direction and flow velocity

This paper presents a unified theory for different measurement concepts of a thermal flow sensor. Based on this theory, a new flow sensor concept is derived. The concept allows measuring both direction and velocity of a fluid flow with a heater and an array of temperature sensors. This paper first analyzes the two-dimensional (2-D) forced convection problem with a laminar flow. The two operation modes of a constant heating power and of a constant heater temperature are considered in the analytical model. A novel estimation algorithm was derived for the flow direction. Different methods for velocity measurement were presented: the hot-wire method, the calorimetric method, and the novel average-temperature method. The only geometric parameter of the sensor, the dimensionless position of the sensor array, is optimized based on the analytical results. Furthermore, the paper presents the experimental results of the sensor prototype. In order to verify the analytical model, an array of temperature sensors was used for recording the 2-D temperature profile around the heater. Temperature values are transferred to a computer by a multiplexer. A program running on a personal computer extracts the actual flow velocity and flow direction from the measured temperature data. This paper discusses different evaluation algorithms, which can be used for this sensor. A simple Gaussian estimator was derived for the direction measurement. This estimator provides the same accuracy as the analytical estimator. Velocity results of both the calorimetric concept and the novel average-temperature concept are also presented.
A Unified Query-based Generative Model for Question Generation and Question Answering

We propose a query-based generative model for solving both tasks of question generation (QG) and question an- swering (QA). The model follows the classic encoder- decoder framework. The encoder takes a passage and a query as input then performs query understanding by matching the query with the passage from multiple per- spectives. The decoder is an attention-based Long Short Term Memory (LSTM) model with copy and coverage mechanisms. In the QG task, a question is generated from the system given the passage and the target answer, whereas in the QA task, the answer is generated given the question and the passage. During the training stage, we leverage a policy-gradient reinforcement learning algorithm to overcome exposure bias, a major prob- lem resulted from sequence learning with cross-entropy loss. For the QG task, our experiments show higher per- formances than the state-of-the-art results. When used as additional training data, the automatically generated questions even improve the performance of a strong ex- tractive QA system. In addition, our model shows bet- ter performance than the state-of-the-art baselines of the generative QA task.
The East African Higher Education Area: A Global or Regional Higher Education Space?

This Chapter discusses the feasibility of the East African Community Higher Education area (EACHEA) as a common higher education space for the East African Partner states. Attempts to establish the EACHEA have been in process since the passing of the Arusha Convention treaty on 5thDecember 1981. The treaty was subsequently
The Informal Economy in pan-Africa: Review of the Literature, Themes, Questions, and Directions for Management Research1

ABSTRACT The informal economy is an important phenomenon in African countries, accounting for up to 90% of the jobs in the lowest income Sub-Saharan countries such as Central African Republic and the Democratic Republic of the Congo. Management research about Africa, therefore, cannot be complete without a closer look at and a better understanding of the informal economy on the continent, the opportunities it brings and challenges it faces. Research on the informal economy started during the early 1970s has been conducted mainly by economists and sociologists. Managerial and organizational knowledge of the informal economy in Africa, however, remains largely underdeveloped. We reviewed the literature on the informal economy taking a pan-African approach by surveying 102 studies published from 1992 to 2017 in English, French and Portuguese language outlets. We summarize the current state of the literature, identify seven general themes, raise pertinent research questions, and suggest directions to further advance research about the informal economy with a focus on management and organization knowledge in all of Africa.
Characteristics of Neisseria meningitidis isolates causing fatal disease

The objectives of the present study were to describe a selection of characteristics of all available fatal meningococcal isolates (n=62) and to compare these with all the other invasive isolates (non-fatal, n=474) collected in Sweden from 1995 to 2004 (fatality rate of 12%). The coverage of the fatal isolates by presently discussed outer membrane vesicle (OMV) vaccines was also estimated. The isolates were characterized by serogroup, serotype, genosubtype, multilocus sequence type and antibiogram. Basic epidemiological data were gathered. The results of the fatal isolates showed 55% serogroup B, 27% C, 15% Y and 3% W-135, with a fatality rate of 11% for B, 12% for C, 17% for Y and 8% for W-135. Characteristics associated with higher mortality were age, gender, serogroup Y, serotype 14 and 15 and genosubtypes P1.7,16-29,35 and P1.5-1,10-4,36-2. In contrast, non-14/non-15 serotypes, the genosubtypes P1.5-1,10-8,36-2; P1.7-2,4,37 and P1.7,16,35, as well as reduced sensitivity for penicillin G were associated with decreased mortality. The presently discussed OMV vaccines could, based solely on the complete genosubtype, theoretically cover up to 44% of the fatal serogroup B cases and up to 100% if every variable region by itself is capable to induce protective immunity.
Early prediction of neurological sequelae or death after bacterial meningitis

This study determined independent predictors of the occurrence of permanent neurological sequelae or death after childhood bacterial meningitis. Data were used from a large study on children (aged 1 mo to 15 y) initially presenting with meningeal irritation. A nested case‐control study was performed on children with (n= 23) and without (n= 70) permanent neurological sequelae (hearing impairment, locomotor dysfunction, mental retardation or epilepsy) or death after bacterial meningitis. Predictors obtained from clinical evaluation and laboratory tests at presentation and during the clinical course were identified by multivariate logistic regression and receiver operating characteristic (ROC) curve analyses. The study population comprised 23 cases and 70 controls (52% boys, median age 2.8 y). Independent predictors for an adverse outcome after bacterial meningitis were male gender, atypical convulsions in history, low body temperature at admission and the pathogen Streptococcus pneumoniae. The area under the ROC curve of this prediction rule was 0.87 (95% confidence interval: 0.78–0.96), which was not improved by adding other characteristics. A score including these independent predictors could classify patients into categories with increasing risk for an adverse outcome.
Phase‐shifting human circadian rhythms: influence of sleep timing, social contact and light exposure.

1. Both the timing of behavioural events (activity, sleep and social interactions) and the environmental light‐dark cycle have been reported to contribute to entrainment of human circadian rhythms to the 24 h day. Yet, the relative contribution of those putative behavioural synchronizers to that of light exposure remains unclear. 2. To investigate this, we inverted the schedule of rest, sedentary activity and social contact of thirty‐two young men either with or without exposure to bright light. 3. On this inverted schedule, the endogenous component of the core temperature rhythm of subjects who were exposed to bright light showed a significant phase shift, demonstrating that they were adapting to the new schedule. In contrast, the core temperature rhythm of subjects who were not exposed to bright light moved on average 0.2 h later per day and after 10 days had not significantly adapted to the new schedule. 4. The direction of phase shift in the groups exposed to bright light was dependent on the time of bright light exposure, while control subjects drifted to a later hour regardless of the timing of their schedule of sleep timing, social contact and meals. 5. These results support the concept that the light‐dark cycle is the most important synchronizer of the human circadian system. They suggest that inversion of the sleep‐wake, rest‐activity and social contact cycles provides relatively minimal drive for resetting the human circadian pacemaker. 6. These data indicate that interventions designed to phase shift human circadian rhythms for adjustment to time zone changes or altered work schedules should focus on properly timed light exposure.