Miracle-dz/UniFAR-FTUs huggingface dataset:
Running Head : AMP : HOT OR NOT ? The Affect Misattribution Procedure : Hot or Not ?

The Affect Misattribution Procedure (AMP; Payne et al., 2005) is an important tool in implicit social cognition research, but its underlying mechanisms are still unknown. This paper investigates whether, as the name implies, affect-based processes really underlie the AMP. We used a modified AMP that enabled us to separate the influence of affective and non-affective processes. In three studies, evidence for the implication of non-affective processes was consistently found. In contrast, there was no evidence for affect-based processes. Thus, the AMP rather seems cold than hot. The generalizability of the results obtained with the modified AMP is discussed.
Intratracheal Instillation of Cytoplasmic Granules from Phleum pratense Pollen Induces IgE- and Cell-Mediated Responses in the Brown Norway Rat

Background: Release of cytoplasmic granules from grass pollen upon contact with water is thought to be an important source of airborne allergens. Objectives: To investigate the humoral and cellular responses to intratracheal instillation of Phleum pratense (timothy grass) pollen cytoplasmic granules (PCG) in the Brown Norway rat. Methods: PCG were purified from timothy grass pollen by filtration through 5-µm-mesh filters. Rats were sensitized (day 0) and challenged (day 21) intratracheally with purified PCG suspended in saline (6 × 106 PCG/rat). Rats were then challenged 4 weeks later (1.5 × 106 PCG/rat). Blood samples, bronchial lymph nodes and lungs were collected from the rats 4 days after the second challenge. PCG-specific IgE and IgG1 levels and specificity were determined by ELISA and Western blotting. Pollen, pollen extract and PCG-induced proliferation of lymph node cells were monitored by [3H]-thymidine incorporation in a lymph node assay. Histopathological examination was carried out on the lungs. Results: Specific IgE and IgG1 were present in the sera. Cultured lymph node cells proliferated in the presence of pollen, pollen extract and PCG. Western blots showed that all major pollen allergens are recognized by IgE and IgG1 from PCG-treated rats. Histopathological examination revealed features of a mild allergic reaction. Conclusions: In our rat model of allergy, purified timothy grass PCG instillation induced specific antibodies and lymph node cell responses, comparable to those obtained with intact pollen.
Effect of Dose on the Frequency of Major Birth Defects Following Fetal Exposure to Lamotrigine Monotherapy in an International Observational Study

Summary: Data from the International Lamotrigine Pregnancy Registry were analyzed to examine the effect of maximal first‐trimester maternal dose of lamotrigine monotherapy on the risk of major birth defects (MBDs). Among 802 exposures, the frequency of MBDs was 2.7% (95% confidence interval [CI] 1.8–4.2%). The distribution of dose did not differ between infants with and those without MBDs (mean 248.3 milligrams per day [mg/day] and 278.9 mg/day, respectively, median 200 mg/day for both groups). A logistic regression analysis showed no difference in the risk of MBDs as a continuous function of dose (summary odds ratio [OR] per 100 mg increase =0.999, 95% CI 0.996–1.001). There was also no effect of dose, up to 400 mg/day, on the frequency of MBDs.
Model-Powered Conditional Independence Test

We consider the problem of non-parametric Conditional Independence testing (CI testing) for continuous random variables. Given i.i. d samples from the joint distribution $f(x,y,z)$ of continuous random vectors $X,Y$ and $Z,$ we determine whether $X \perp Y | Z$. We approach this by converting the conditional independence test into a classification problem. This allows us to harness very powerful classifiers like gradient-boosted trees and deep neural networks. These models can handle complex probability distributions and allow us to perform significantly better compared to the prior state of the art, for high-dimensional CI testing. The main technical challenge in the classification problem is the need for samples from the conditional product distribution $f^{CI}(x,y,z) = f(x|z)f(y|z)f(z)$ -- the joint distribution if and only if $X \perp Y | Z. $ -- when given access only to i.i. d. samples from the true joint distribution $f(x,y,z)$. To tackle this problem we propose a novel nearest neighbor bootstrap procedure and theoretically show that our generated samples are indeed close to $f^{CI}$ in terms of total variational distance. We then develop theoretical results regarding the generalization bounds for classification for our problem, which translate into error bounds for CI testing. We provide a novel analysis of Rademacher type classification bounds in the presence of non-i.i. d near-independent samples. We empirically validate the performance of our algorithm on simulated and real datasets and show performance gains over previous methods.
Abundance and Distribution of Iron on the Moon

The abundance and distribution of iron on the moon is derived from a near-global data set from Clementine. The determined iron content of the lunar highlands crust (∼3 percent iron by weight) supports the hypothesis that much of the lunar crust was derived from a magma ocean. The iron content of lower crustal material exposed by the South Pole-Aitken impact basin on the lunar farside is higher (∼7 to 8 percent by weight) and consistent with a basaltic composition. This composition supports earlier evidence that the lunar crust becomes more mafic with depth. The data also suggest that the bulk composition of the moon differs from that of the Earth's mantle. This difference excludes models for lunar origin that require the Earth and moon to have the same compositions, such as fission and coaccretion, and favors giant impact and capture.
Automated Tuning of Parallel I/O Systems: An Approach to Portable I/O Performance for Scientific Applications

Parallel I/O systems typically consist of individual processors, communication networks, and a large number of disks. Managing and utilizing these resources to meet performance, portability, and usability goals of high performance scientific applications has become a significant challenge. For scientists, the problem is exacerbated by the need to retune the I/O portion of their code for each supercomputer platform where they obtain access. We believe that a parallel I/O system that automatically selects efficient I/O plans for user applications is a solution to this problem. The authors present such an approach for scientific applications performing collective I/O requests on multidimensional arrays. Under our approach, an optimization engine in a parallel I/O system selects high quality I/O plans without human intervention, based on a description of the application I/O requests and the system configuration. To validate our hypothesis, we have built an optimizer that uses rule based and randomized search based algorithms to tune parameter settings in Panda, a parallel I/O library for multidimensional arrays. Our performance results obtained from an IBM SP using an out-of-core matrix multiplication application show that the Panda optimizer is able to select high quality I/O plans and deliver high performance under a variety of system configurations with a small total optimization overhead.
Ticagrelor: Positive, negative and misunderstood properties as a new antiplatelet agent

Dual antiplatelet therapy is essential for the management of acute coronary syndrome. In particular, combination therapy using aspirin with a platelet ADP (i.e. P2Y12) receptor inhibitor, such as clopidogrel, prasugrel or, more recently, ticagrelor, has been recommended for patients with acute coronary syndrome. Pharmacological agents that reversibly inhibit platelet aggregation without metabolic activation in the liver are believed to reduce cardiovascular mortality compared with the current drug of choice for antiplatelet therapy, namely clopidogrel. These findings are based on a multicentre, double‐blind, double‐dummy, randomized controlled trial. Numerous factors are postulated to contribute to the improved survival of patients who take ticagrelor compared with those taking clopidogrel, including the risk of myocardial infarction, heart failure, arrhythmia and bleeding. In addition, clopidogrel may lead to a much higher incidence of infection. Although ticagrelor has recently been approved for use in the US and exhibits superiority over other antiplatelet agents, certain concerns remain regarding its use, including lung injury and dyspnoea, thus raising the issue of its true superiority over clopidogrel or prasugrel. Recent studies into ticagrelor report conflicting data, with certain aspects of its mechanisms of action still not fully understood. Ticagrelor has beneficial effects following its clinical application, such as achieving overall higher reductions in mortality compared with the use of clopidogrel and prasugrel. Harmful effects associated with the use of ticagrelor include a higher incidence of dyspnoea and major bleeding compared with clopidogrel.
Verification of Relative Output Factor ( ROF ) Measurement for Radiosurgery Small Photon Beams

Particular attention may be paid to reassess for treatment planning systems (TPSs) that deal with specialized techniques such as stereotactic radiosurgery. It is important for clinical medical physicist to be able to quantify errors involved in the dosimetric parameter data before it can be downloaded into the TPS. The purpose of this study was to verify the measurement of relative output factor (ROF), which is one of the dosimetric parameter data required for Stereotactic Radiosurgery (SRS) treatment planning. ROF of 5 mm to 45 mm diameter Radionic circular cone collimators were measured using three types of ionization chambers, which were A12 Extradin Farmer-type Chamber (0.65 cc), A14 Extradin Microchamber (0.016 cc) and PTW Pinpoint Ionization Chamber (0.016 cc). The ROF measurements were verified using a Monte Carlo (EGSnrc) validated model and other previous studies. In conclusion, pinpoint ionization chamber gave the most reliable ROF result for field size from 5 mm to 45 mm compared to other ionization chambers used in this study. The ROF measurement using pinpoint ionization chamber was in good agreement with the Monte Carlo calculation (± 4.9% percentage deviation). Therefore for measurement of ROF for SRS circular field size, pinpoint ionization chamber was suggested due to its accuracy. This ROF validation test can be carried out during the commissioning and installation of the new TPS and also for annually quality assurance (QA). Raduan et al. 2016 Health and the Environment Journal, 2016, Vol 7, No 2 pp 2031 21
The air‐Q® intubating laryngeal airway vs the LMA‐ProSealTM: a prospective, randomised trial of airway seal pressure *

We performed a prospective, open‐label, randomised controlled trial comparing the air‐Q® against the LMA‐ProSeal™ in adults undergoing general anaesthesia. One hundred subjects (American Society of Anesthesiologists physical status 1–3) presenting for elective, outpatient surgery were randomly assigned to 52 air‐Q® and 48 ProSeal devices. The primary study endpoint was airway seal pressure. Oropharyngolaryngeal morbidity was assessed secondarily. Mean (SD) airway seal pressures for the air‐Q® and ProSeal were 30 (7) cmH2O and 30 (6) cmH2O, respectively (p = 0.47). Postoperative sore throat was more common with the air‐Q® (46% vs 38%, p = 0.03) as was pain on swallowing (30% vs 5%, p = 0.01). In conclusion, the air‐Q® performs well as a primary airway during the maintenance of general anaesthesia with an airway seal pressure similar to that of the ProSeal, but with a higher incidence of postoperative oropharyngolaryngeal complaints.
Association between Interferon Regulatory Factor 6 Gene Polymorphisms and Nonsyndromic Cleft Lip with or without Cleft Palate in a Chinese Population

Objective To further confirm the association between two IRF6 single nucleotide polymorphisms and nonsyndromic cleft lip with or without cleft palate in a Chinese population. Participants A total of 106 nonsyndromic cleft lip with or without cleft palate case trios and 129 control trios. Intervention Two IRF6 single nucleotide polymorphisms, rs2235371 and rs642961, were genotyped for all case and control families. Case-control analysis and family-based linkage analysis were both performed for the two single nucleotide polymorphisms. Results The genotype and allele frequencies of rs2235371 (odds ratioAG+AA vs. GG, 0.581; 95% confidence interval, 0.345 to 0.976; P = .039) and rs642961 (odds ratioAG+AA vs. GG, 5.389; 95% confidence interval, 2.936 to 9.893; P = 5e-08) were significantly higher in nonsyndromic cleft lip with or without cleft palate patients compared with controls. There was an obvious dosage effect of allele A at rs642961. The transmission of a major allele (G) of rs2235371 and a minor allele (A) of rs642961 was in disequilibrium (P < .05) in complete case-parent trios. The association between the two single nucleotide polymorphisms and nonsyndromic cleft lip with or without cleft palate was confirmed by the Family-Based Association Test for rs642961 (P = .008), but there was no significance for rs2235371 (P = 0.057). Haplotype analysis found that rs2235371 G/rs642961 A haplotype increased the risk of nonsyndromic cleft lip with or without cleft palate (P = 2.42e-07); whereas, rs2235371 A/rs642961 G haplotype reduced the risk of nonsyndromic cleft lip with or without cleft palate (P = 4.37e-05). No evidence of linkage disequilibrium was found between the two single nucleotide polymorphisms (D′ = 0.303, r2 = 0.017). Conclusion Our results confirmed the involvement of the IRF6 variants rs642961 and rs2235371 in the etiology of nonsyndromic cleft lip with or without cleft palate in a Chinese population.
Teaching medical ethics to first‐year students by using film discussion to develop their moral reasoning

PURPOSE. To evaluate a project on teaching medical ethics to first-year students by using film discussion to develop the students' moral reasoning. METHOD. The participants were 114 first-year students at Texas A&M University Health Science Center College of Medicine in 1989–90, 1990–91, and 1991–92: (1) 48 (20 women and 28 men) who participated during the fall quarter in an elective course on social issues in medicine, which consisted of weekly one-hour discussions of short films; (2) 37 (18 women and 19 men) who participated in the course during both the fall and winter quarters; and (3) a control group of 29 (8 women and 21 men) who did not take the course and so had no exposure to the film discussions. The influence of the discussions on the students' moral reasoning was measured by using Rest's Defining Issues Test for pretests and posttests. The scores of the three groups were compared by using multivariate analysis of variance. RESULTS. There were statistically significant increases in the moral reasoning scores of both the course registrants with one-quarter exposure to the film discussions (p < .002) and those with two-quarter exposure (p < .008) compared with the scores of the students who did not take the course and had no exposure (p < .109). CONCLUSION. No doubt there was a self-selecting bias on the part of the course registrants; however, since both groups of registrants showed significant increases on their posttest scores, clearly the course did have a positive influence on these students' moral reasoning. Thus, it is possible to develop young people's moral reasoning in medical school as well as in earlier educational environments.
Serum IL-9 Levels Depend on Allergen Exposure: Preliminary Study

Background: Th9 is a new T cell subset characterized by interleukin 9 (IL-9) production. Serum IL-9 levels are related to symptom severity in patients with allergic rhinitis (AR). This study aimed at investigating whether IL-9 may depend on allergen exposure. Methods: 35 AR patients (16 males, mean age 33.2 years) with monosensitization to Parietaria were studied when symptomatic; 38 AR patients (22 males, mean age 30.9 years) with monosensitization to birch were recruited at the same time, but were symptom free. Serum IL-9 was assayed in all patients. Results: Patients with Parietaria allergy and exposed to allergen had higher serum IL-9 levels than patients with birch allergy and not exposed to allergen (p < 0.05). Conclusions: This preliminary study shows that serum IL-9 levels may depend on allergen exposure: symptomatic patients with pollen-induced AR, evaluated during the pollen season, have higher values than patients studied outside the pollen season and without symptoms.
Screening for fetal alcohol syndrome in primary schools: a feasibility study.

BACKGROUND This project was undertaken as a feasibility study to determine the possibility of screening for fetal alcohol syndrome (FAS) in early school-age children for epidemiological and interventional purposes. METHODS All elementary schools in two counties in Washington State were asked to screen first graders for possible FAS. A child was screen positive if found to be growth deficient, to have certain specific facial abnormalities, or have a known history of substantial alcohol exposure in gestation. All screen-positive children were invited to "special diagnostic clinics" for final diagnosis and treatment planning. RESULTS In County A, virtually all students were screened. In County B only about 25% of children were screened. This difference was related to the number of schools that agreed to participate in the project and the methods employed by each county to obtain parental permission. In each county, only about one-half of the screen-positive children were seen in the special clinics for diagnostic considerations. Only one of the seven children found to have FAS had been diagnosed previously. The minimal prevalence of FAS in County A was 3.1 in 1,000 students. The minimal prevalence of FAS in County B could not be calculated. The most efficient component in the screening process leading to a diagnosis of FAS was finding the specific facial features of the disorder. The diagnosis of FAS was generally helpful in improving educational planning. CONCLUSIONS This study demonstrated that population-based FAS screening within a school system may be possible, but participation is dependent on local trust and understanding of the project before its inception within the schools and the community at large.
Stimulation of sudomotor axon reflex mechanism by carbachol in healthy subjects and patients suffering from diabetic polyneuropathy

Sudomotor axon reflex (SAR) mechanism was stimulated by percutaneous iontophoresis of carbachol in healthy subjects and patients suffering from diabetic polyneuropathy (PNP) of differing severity (stage I‐III). SAR response was assessed by hygrometry and compared with histamine induced neurogenic vasodilatation (laser‐Doppler flowmetry) and itching sensation (visual analogue scale), which may provide information on neuro‐secretion and afferent function of nociceptive unmyelinated nerve fibers. Carbachol induced long lasting SAR response with maximal sweating rates 20–30 minutes after stimulus onset. In diabetic patients the carbachol induced SAR response and the histamine induced itching sensation were significantly reduced in stage III of PNP. In contrast, histamine induced vasodilatation was significantly impaired in all stages of PNP. It is concluded that prolonged SAR response following iontophoresis of carbachol can simplify evaluation of sudomotor function when compared to established tests using intradermal application of acetylcholine. Furthermore, to demonstrate impairment of unmyelinated nerve fibers in PNP, histamine induced vasodilatation was found to be more sensitive than SAR response.
Detection of Utilizable Capacity Deterioration in Battery Systems

Lithium ion (Li-ion) batteries exhibit high power and energy densities, as well as high-cycle-lifetime capabilities. Li-ion cells based on LiFePO4 cathodes are promising alternatives to predominant metal oxide technologies, particularly for applications with high power and cycle lifetime requirements. This paper includes investigations on high-power LiFePO4 cells' cycle lifetime. Therefore, 3000 full charge-discharge cycles are applied to the cells with high constant current rates. Through reference testing, increasing battery impedance and a fading capacity are identified as a consequence of battery aging. Capacity fade proceeds in a way that cells' open-circuit voltages (OCVs) change only in the range of high state-of-charge (SOC). A model-based method that can detect the decreasingly utilizable capacity is outlined. The proposed method considers the changing OCV characteristics and enables the determination of capacity loss without complete charge and discharge being necessary during battery operation. By the evaluation of capacity loss information, an accelerated battery aging or even possible battery damage caused by overcharge can be avoided during battery charging scenarios.
AN AUDIO ENGINEERING SOCIETY PREPRINT

- This paper focuses on the energy compaction properties of five different transforms: DFT, DCT, SDFT((N+1)/2, 1/2), MDCT and DST. Energy compaction properties of these transforms are compared experimentally. In addition to sinusoidal signals, sixteen classical and pop music pieces are used for the experiments. The influence of different window sizes (256, 512 and 1024 samples) and different window shapes (rectangular and sine) are investigated. The results of the experiments are presented and analyzed.
Evaluating Business Value of IT in Healthcare in Australia: The Case of an Intelligent Operational Planning Support Tool Solution

The healthcare sector is complex and intricate. It consists of a web of players including clinicians, healthcare organisations, regulators, payers, suppliers, patients and their families to mention the major groups. Taken together they form a complex ecosystem made up of multiple and dynamic sub-ecosystems. With the focus on incorporating technology into this context what we find is one of the most intricate and complex of e-ecosystems that must function effectively and efficiently in order to provide superior care and treat patients. The following tries to ascertain the value associated with the application of technology in healthcare; i.e. the business value of IT in healthcare. This is done by synthesising key literature and then applying it to a specific case of a nursing informatics technology solution. In so doing, a unifying framework is established that enables us to understand key activities that occur throughout this e-ecosystem.
Pancreatic pseudocysts: A proposed classification and its management implications

Pancreatic pseudocysts in 83 patients were classified according to clinical and radiographic criteria. Group I (45 patients) had acute, ‘post‐necrotic’ pseudocysts with normal pancreatic duct anatomy and rarely duct—pseudocyst communication. Percutaneous drainage was curative in all patients in whom it was used. Group II (26 patients) included ‘post‐necrotic’ pseudocysts developing in patients already suffering from chronic pancreatitis. The pancreatic duct was diseased but not strictured, and duct—pseudocyst communication was often present. Percutaneous drainage is possible for such patients but it may have to be prolonged; surgical internal drainage was usually successful. Group III (12 patients) had chronic ‘retention’ pseudocysts. The pancreatic duct was grossly diseased and strictured and duct—pseudocyst communication was present in all cases. Percutaneous drainage is contraindicated and surgical internal drainage has a high recurrence rate. Operative procedures in this group should address the specific ductal pathology. An improved classification of pseudocysts could help the surgeon to choose the most appropriate form of treatment.