Miracle-dz/UniFAR-FTUs huggingface dataset:
A novel stylized model for platform ecosystem dynamics: Understanding IT service transformation from firm theory perspective

Abstract This paper studies platform ecosystems, which refer to a novel solution built upon a platform coordinating business interactions between suppliers and users, particularly in the IT service sectors. Borrowing words from two fundamental firm theories—resource-based view (RBV) and transaction cost view (TCV)—we argue that the platform ecosystem works at the boundary between “market and hierarchy. ” We also develop a stylized model for the platform ecosystem, in which attributes like installed-base and heterogeneity and platform’s investment are the primary ingredients for RBV and TCV, respectively. Our findings based on equilibrium analyses and simulations largely confirm that both RVB and TCV are valid for understanding a platform ecosystem. We, however, also identify some contingencies where RBV is limited, and propose a hypothesis that the platform’ investment is more crucial for fostering an ecosystem. This implies that the platform starts from the point near market and maneuvers the ecosystem toward a hierarchy, utilizing its investment as a driver.
THE ROLE OF FACEBOOK AS A SOCIAL MEDIA MARKETING ON HOUSEWIVES’ START-UP BUSINESS

Social media marketing is one of several marketing models, and as the name suggests, it utilizes social media, which is used by most people nowadays, to market or promote a product, a service, a brand, or an issue. This study aims to analyze how influential is the role of Facebook to several housewives’ start-up business. This study uses qualitative approach, which utilizes interviews in order to understand the marketing strategy through social media that is implemented by several housewives’ start-up business. The marketing strategy that is implemented by these housewives’ start-up business corresponds with developments in the current age, in which everything is IT-based. The Facebook as a social media marketing that these housewives’ start-up business implement can be categorized as a good marketing strategy. This can be proven with the achievement of outputs that are created during the implementation of these housewives’ social media marketing strategy and with positive impacts that this strategy has created, especially on the increase of productivity, profit, competitiveness, and competence, as well as on the creation of a good image among their enterprises. However, the problem for these housewives’ start-up business comes from their own inactivity in the marketing process, and this affects their customers as the customers find it hard to find information about these enterprises. Thus, it can be concluded that the marketing strategy that these housewives’ start-up business implement, which is social media marketing, has an important role in the success of their enterprises.
The relationship of aerobic capacity, anaerobic peak power and experience to performance in CrossFit exercise

CrossFit is becoming increasingly popular as a method to increase fitness and as a competitive sport in both the Unites States and Europe. However, little research on this mode of exercise has been performed to date. The purpose of the present investigation involving experienced CrossFit athletes and naïve healthy young men was to investigate the relationship of aerobic capacity and anaerobic power to performance in two representative CrossFit workouts: the first workout was 12 minutes in duration, and the second was based on the total time to complete the prescribed exercise. The participants were 32 healthy adult males, who were either naïve to CrossFit exercise or had competed in CrossFit competitions. Linear regression was undertaken to predict performance on the first workout (time) with age, group (naïve or CrossFit athlete), VO2max and anaerobic power, which were all significant predictors (p < 0.05) in the model. The second workout (repetitions), when examined similarly using regression, only resulted in CrossFit experience as a significant predictor (p < 0.05). The results of the study suggest that a history of participation in CrossFit competition is a key component of performance in CrossFit workouts which are representative of those performed in CrossFit, and that, in at least one these workouts, aerobic capacity and anaerobic power are associated with success.
Pregnancy outcome among obese paturients at the University of Port Harcourt Teaching Hospital, Nigeria

There is concern for very obese women and their pregnancy outcomes as obesity confers increased risk of maternal and perinatal complications. This study aims to determine the prevalence of obesity in pregnancy and the maternal and foetal risk of adverse pregnancy outcome in relation to maternal obesity. This prospective study was carried out at the University of Port Harcourt Teaching Hospital (UPTH) between May 2006 and April 2007. A cohort of 150 pregnant women with BMI ≥ 30kg/m2 who registered for antenatal care were identified and compared with a control group of 150 non-obese pregnant women. The incidence of obesity in the study was 6.0%. More of the obese patients were of low parity. Sixty percent of the obese women had tertiary education. Preeclampsia (14%), malpresentations (5.3%) and prolonged pregnancy (24%) were significantly more common in the obese group. The Caesarean section rate was also higher in the obese group (p<0.001). Foetal macrosomia and birth asphyxia were significantly higher among the obese group (p=0.001). Pregnancy in obese women presents a certain amount of risk and there is need for close surveillance to reduce these obesity-related complications in pregnancy.
Cyclooxygenase-2 Induction and Prostacyclin Release by Protease-activated Receptors in Endothelial Cells Require Cooperation between Mitogen-activated Protein Kinase and NF-κB Pathways*

The functional significance of protease-activated receptors (PARs) in endothelial cells is largely undefined, and the intracellular consequences of their activation are poorly understood. Here, we show that the serine protease thrombin, a PAR-1-selective peptide (TFLLRN), and SLIGKV (PAR-2-selective peptide) induce cyclooxygenase-2 (COX-2) protein and mRNA expression in human endothelial cells without modifying COX-1 expression. COX-2 induction was accompanied by sustained production of 6-keto-PGF1α, the stable hydrolysis product of prostacyclin, and this was inhibited by indomethacin and the COX-2-selective inhibitor NS398. PAR-1 and PAR-2 stimulation rapidly activated both ERK1/2 and p38MAPK, and pharmacological blockade of MEK with either PD98059 or U0126 or of p38MAPK by SB203580 or SB202190 strongly inhibited thrombin- and SLIGKV-induced COX-2 expression and 6-keto-PGF1α formation. Thrombin and peptide agonists of PAR-1 and PAR-2 increased luciferase activity in human umbilical vein endothelial cells infected with an NF-κB-dependent luciferase reporter adenovirus, and this, as well as PAR-induced 6-keto-PGF1α synthesis, was inhibited by co-infection with adenovirus encoding wild-type or mutated (Y42F) IκBα. Thrombin- and SLIGKV-induced COX-2 expression and 6-keto-PGF1α generation were markedly attenuated by the NF-κB inhibitor PG490 and partially inhibited by the proteasome pathway inhibitor MG-132. Activation of PAR-1 or PAR-2 promoted nuclear translocation and phosphorylation of p65-NF-κB, and thrombin-induced but not PAR-2-induced p65-NF-κB phosphorylation was reduced by inhibition of MEK or p38MAPK. Activation of PAR-4 by AYPGKF increased phosphorylation of ERK1/2 and p38MAPK without modifying NF-κB activation or COX-2 induction. Our data show that PAR-1 and PAR-2, but not PAR-4, are coupled with COX-2 expression and sustained endothelial production of vasculoprotective prostacyclin by mechanisms that depend on ERK1/2, p38MAPK, and IκBα-dependent NF-κB activation.
The Relationship between Bank Profitability and Micro Variables with Particular Emphasis on Bank Type: The Case of Northern Cyprus

Given the fact that profitability is vital for sustainability, the main aim of this study was to determine the relationship between bank profitability and micro variables, with particular emphasis on bank type for the banking sector of Northern Cyprus. Cross-tabulation was applied to examine whether different bank types reveal similar levels of profitability. The profitability of the Northern Cyprus banking sector was profitable, even though real growth rates were negative during the periods concerned. However, the profitability of branch banks and foreign-capitalized banks was found to be higher for structural, managerial, technical and economic reasons. The banking sector of Northern Cyprus has stable profitability. Because of their unique characteristics, different bank types naturally have dissimilar profitability structures. Furthermore, equity, personnel expenses, non-performing loans and total deposits are negatively correlated with profitability, while total loans are positively correlated with profitability.
Influence of CXCR4/SDF-1 axis on E-cadherin/β-catenin complex expression in HT29 colon cancer cells.

AIM To study the influence of CXCR4/stromal cell-derived factor-1 (SDF-1) axis on E-cadherin/β-catenin complex expression in HT29 colon cancer cells and its underlying mechanisms. METHODS Effect of SDF-1 on E-cadherin/β-catenin expression was detected by immunocytochemistry. E-cadherin and β-catenin mRNA expression levels were measured by reverse transcriptase-polymerase chain reaction. SDF-1-induced phosphorylation of phosphatidylinositol 3-kinase (PI3K)/AKT and β-catenin was detected by Western blotting. RESULTS The E-cadherin and β-catenin mRNA expression levels in HT29 cells were lower 48 h after incubated with SDF-1 at the concentrations of 20 and 40 ng/mL (P<0.05). SDF-1-induced significant phosphorylation of PI3K/AKT and β-catenin. AMD3100 and LY294002 inhibited the phosphorylation of PI3K/AKT and β-catenin. CONCLUSION SDF-1 down-regulates the E-cadherin/β-catenin complex expression in HT29 cells by decreasing mRNA synthesis and increasing β-catenin phosphorylation.
Succession planning: a call to action for nurse executives.

AIM To discuss the organisational benefits of strategic succession planning in acute care hospital settings as a responsibility of chief nurse executives. BACKGROUND A formal succession planning process is crucial to the financial and operational viability and sustainability of acute care hospitals. A succession plan is an essential business strategy that promotes effective leadership transition and continuity while maintaining productivity. EVALUATION Nursing and business literature were reviewed; reports contrasting institutions with and without succession plans were examined; and, operational implications were considered. KEY ISSUES It is imperative that chief nurse executives respond to the business benefits of an effective succession planning programme, identify common barriers and solutions, and implement best practices for a successful strategic succession planning programme. CONCLUSION A strategic succession planning programme may offer many benefits to an acute care hospital, including improved retention rates, increased staff engagement and enhanced financial performance. IMPLICATIONS FOR NURSING MANAGEMENT Considering the ageing nursing workforce and the potential increase in demand for nursing services in the near future, nurse executives and other nurse leaders must actively engage in a formal succession planning process. A formal succession planning programme will help to provide strategic leadership continuity, operational effectiveness and improved quality of care.
Symbiodinium mitigate the combined effects of hypoxia and acidification on a noncalcifying cnidarian

Anthropogenic nutrient inputs enhance microbial respiration within many coastal ecosystems, driving concurrent hypoxia and acidification. During photosynthesis, Symbiodinium spp. , the microalgal endosymbionts of cnidarians and other marine phyla, produce O2 and assimilate CO2 and thus potentially mitigate the exposure of the host to these stresses. However, such a role for Symbiodinium remains untested for noncalcifying cnidarians. We therefore contrasted the fitness of symbiotic and aposymbiotic polyps of a model host jellyfish (Cassiopea sp.) under reduced O2 (~2.09 mg/L) and pH (~ 7.63) scenarios in a full‐factorial experiment. Host fitness was characterized as asexual reproduction and their ability to regulate internal pH and Symbiodinium performance characterized by maximum photochemical efficiency, chla content and cell density. Acidification alone resulted in 58% more asexual reproduction of symbiotic polyps than aposymbiotic polyps (and enhanced Symbiodinium cell density) suggesting Cassiopea sp. fitness was enhanced by CO2‐stimulated Symbiodinium photosynthetic activity. Indeed, greater CO2 drawdown (elevated pH) was observed within host tissues of symbiotic polyps under acidification regardless of O2 conditions. Hypoxia alone produced 22% fewer polyps than ambient conditions regardless of acidification and symbiont status, suggesting Symbiodinium photosynthetic activity did not mitigate its effects. Combined hypoxia and acidification, however, produced similar numbers of symbiotic polyps compared with aposymbiotic kept under ambient conditions, demonstrating that the presence of Symbiodinium was key for mitigating the combined effects of hypoxia and acidification on asexual reproduction. We hypothesize that this mitigation occurred because of reduced photorespiration under elevated CO2 conditions where increased net O2 production ameliorates oxygen debt. We show that Symbiodinium play an important role in facilitating enhanced fitness of Cassiopea sp. polyps, and perhaps also other noncalcifying cnidarian hosts, to the ubiquitous effects of ocean acidification. Importantly we highlight that symbiotic, noncalcifying cnidarians may be particularly advantaged in productive coastal waters that are subject to simultaneous hypoxia and acidification.
Mathematical modeling of regulatory T cell effects on renal cell carcinoma treatment

We present a mathematical model to study the effects of the regulatory T cells (T$_{\textrm{reg}}$) on Renal Cell Carcinoma (RCC) treatment with sunitinib. The drug sunitinib inhibits the natural self-regulation of the immune system, allowing the effector components of the immune system to function for longer periods of time. This mathematical model builds upon our non-linear ODE model by de Pillis et al. (2009) [13] to incorporate sunitinib treatment, regulatory T cell dynamics, and RCC-specific parameters. The model also elucidates the roles of certain RCC-specific parameters in determining key differences between in silico patients whose immune profiles allowed them to respond well to sunitinib treatment, and those whose profiles did not. Simulations from our model are able to produce results that reflect clinical outcomes to sunitinib treatment such as: (1) sunitinib treatments following standard protocols led to improved tumor control (over no treatment) in about 40% of patients; (2) sunitinib treatments at double the standard dose led to a greater response rate in about 15% the patient population; (3) simulations of patient response indicated improved responses to sunitinib treatment when the patient's immune strength scaling and the immune system strength coefficients parameters were low, allowing for a slightly stronger natural immune response.
A meta‐analysis of the effectiveness of psychological interventions for adults with skin conditions

Skin conditions can be associated with heightened levels of psychological morbidity, suggesting the need for psychological interventions. A number of specific interventions (such as habit reversal) have been developed. However, to date, there has not been a systematic review of the effectiveness of psychological interventions. We sought to systematically evaluate the effectiveness of psychological interventions designed to improve the severity of and adjustment to skin conditions in adults. Database, archival and citation searches were conducted. Studies were included if participants were allocated to either a psychological intervention (excluding educational interventions and complementary therapies) or a comparison condition, and if they measured outcomes relevant to the skin condition. Twenty‐two studies met these inclusion criteria. Effect sizes for each intervention were computed and we also coded a number of potential moderators of intervention efficacy. Psychological interventions were found to have a medium‐sized effect on skin conditions (g = 0·54). The type of skin condition, age of sample, nature of the intervention, time interval between the end of the intervention and follow‐up, and type of outcome measure all moderated the effect of interventions on outcomes. For example, interventions had a medium effect on the severity of the condition (g = 0·40) and psychosocial outcomes (g = 0·53), and a medium‐to‐large effect on itch/scratch reactions (g = 0·67). Psychological interventions are beneficial for people with skin conditions. However, more research is needed to extend the variety and focus of the psychological interventions that are available. Studies are also needed to explore the longer‐term benefits of such interventions.
An Investigation on Task-Technology Fit of Mobile Nursing Information Systems for Nursing Performance

This study investigates factors affecting the fit between nursing tasks and mobile nursing information systems and the relationships between the task-technology fit of mobile nursing information systems and nurse performance from the perspective of task-technology fit. Survey research recruited nursing staffs as subjects from selected case hospital. A total of 310 questionnaires were sent out, and 219 copies were obtained, indicating a valid response rate of 70.6%. Collected data were analyzed using the structural equation modeling technique. Our study found that dependence tasks have positive effects on information acquisition (&ggr; = 0.234, P < .05) and information identification (&ggr; = 0.478, P < .001), and independent tasks have significant effects on information acquisition (&ggr; = 0.213, P < .05). Therefore, the introduction of mobile nursing information systems in assisting nursing practices can help facilitate both independent and dependent nursing tasks. Our study discovered that the supporting functions of mobile nursing information systems have positive effects on information integration and interpretation (&ggr; = 0.365, P < .001), as well as information acquisition (&ggr; = 0.253, P < .05). The service supports of mobile nursing information systems have positive effects on information acquisition (&ggr; = 0.318, P < .001) and information integration and interpretation (&ggr; = 0.143, P < .01). Furthermore, information identification (&bgr; = .055, P < .05), information acquisition (&bgr; = .176, P < .001), and information integration and interpretation (&bgr; = .706, P < .001) provided using mobile nursing information systems have positive effects on nursing performance, indicating 83.2% of totally explained variance. As shown, the use of mobile nursing information systems could provide nursing staffs with real-time and accurate information to increase efficiency and effectiveness in patient-care duties, further improving nursing performance.
E × B shear pattern formation by radial propagation of heat flux wavesa)

A novel theory to describe the formation of E×B flow patterns by radially propagating heat flux waves is presented. A model for heat avalanche dynamics is extended to include a finite delay time between the instantaneous heat flux and the mean flux, based on an analogy between heat avalanche dynamics and traffic flow dynamics. The response time introduced here is an analogue of the drivers' response time in traffic dynamics. The microscopic foundation for the time delay is the time for mixing of the phase space density. The inclusion of the finite response time changes the model equation for avalanche dynamics from Burgers equation to a nonlinear telegraph equation. Based on the telegraph equation, the formation of heat flux jams is predicted. The growth rate and typical interval of jams are calculated. The connection of the jam interval to the typical step size of the E×B staircase is discussed.
FLOWCYTOMETRIC EVIDENCE OF DNA PLOIDY IN HUMAN BREAST CANCER

Breast cancer is the most common form of malignancy that affect women. Tumor proliferation can be monitored by measuring DNA synthesis using flow cytometry which provides rapid and precise analysis of large numbers of cells. The aim of the present study was to evaluate DNA ploidy in breast cancer and its relationship to other classical clinicopathological parameters (age, tumor size, histological type, grade of cellular differentiation, lymph node status). This study was initiated in September of 2003 and continued until April of 2004. A number of 30 patients diagnosed with mammary carcinoma and subjected to surgery at the III-rd Surgical Clinic of the “Sf. Spiridon” Hospital were taken into consideration. None of the patients were subjected to chemoor radio-therapy prior to surgery. Cell cycle analyses were performed with fresh tumour sample and normal tissue surrounding the tumour. Data were analysed by Modfit (Verity Software House, USA). A number of 12 cases (40%) were cytometrically diploid (DNA index, DI = 1.00), whereas 18 (60%) were nondiploid tumors. In these latter cases, 16 (53.33%) were simple aneuploid and 2 (6.67%) were tetraploid. When aneuploid and tetraploid cases were analyzed as one group, a statistical correlation was evidenced between DNA ploidy and tumor size (p=0.01). Our study indicated that DNA ploidy could be an important factor for estimating the degree of genomic instability which may be reflected by the aggressiveness of the tumor.
Solvent accessibility as a predictive tool for the free energy of inhibitor binding to the HIV‐1 protease

We have developed a simple approach for the evaluation of the free energies of inhibitor binding to the protease of the human immunodeficiency virus (HIV‐1 PR). Our algorithm is based on the observation that most groups that line the binding pockets of this enzyme are hydrophobic in nature. Based on this fact, we have likened the binding of an inhibitor to this enzyme to its transfer from water to a medium of lower polarity. The resulting expression produced values for the free energy of binding of inhibitors to the HIV‐1 PR that are in good agreement with experimental values. The additive nature of this approach has enabled us to partition the free energy of binding into the contributions of single fragments. The resulting analysis clearly indicates the existence of a ranking in the participation of the enzyme's subsites in binding. Although all the enzyme's pockets contribute to binding, the ones that bind the P2‐P'2 span of the inhibitor are in general the most critical for high inhibitor potency. Moreover, our method has allowed us to determine the nature of the functional groups that fit into given enzyme binding pockets. Perusal of the energy contributions of single side chains has shown that a large number of hydrophobic and aromatic groups located in the central portion of the HIV‐1 PR inhibitors present optimal binding. All of these observations are in agreement with experimental evidence, providing a validation for the physical relevancy of our model.