Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparison of rofecoxib and a multidose oxycodone/acetaminophen regimen for the treatment of acute pain following oral surgery: a randomized controlled trial

SUMMARY Objective: To compare the efficacy of a single dose of rofecoxib 50 mg with a single dose of oxycodone/acetaminophen 10/650 mg over 6 h as well as with a multidose regimen of oxycodone/acetaminophen 10/650 mg followed by oxycodone/acetaminophen 5/325 mg over 24 h. Research design and methods: In this double-blind, randomized, two-phase study, patients with moderate to severe pain after surgical extraction of ≥ 2 third molars, including one mandibular impaction, were treated with rofecoxib 50 mg, oxycodone/acetaminophen 10/650 mg (single-dose phase) followed by 5/325 mg every 6 h as needed (multidose phase), or placebo. Patients rated their pain relief and intensity at 18 time points over 24 h. Efficacy was measured over 6 and 24 h by total pain relief (TOPAR), sum of pain intensity difference (SPID), and patient global assessment of response to therapy (PGART). Primary endpoint for the single dose comparison was TOPAR over 6 h; SPID was the key 24-h endpoint. Onset of analgesic effect, peak analgesic effect, and duration of analgesic effect were also evaluated. Adverse experiences were recorded. Results: 271 patients were randomized to treatment with rofecoxib (n = 121), oxycodone/acetaminophen (n = 120), or placebo (n = 30). For the single dose comparison, rofecoxib-treated patients achieved pain relief at least as effective as oxycodone/acetaminophen-treated patients as assessed by TOPAR6 (12.9 vs 11.3, 95% CI on difference = [–0.1, 3.2], p = 0.059). Patients also rated a single dose of rofecoxib as at least as effective as multidose oxycodone/acetaminophen over 24 h on SPID24 (21.9 vs 18.1, 95% CI on difference = [–1.0, 8.8], p = 0.122). Patients treated with oxycodone/acetaminophen had a shorter time to onset of analgesia than patients treated with rofecoxib (24 vs 35 min, p < 0.05). Patients in the active treatment groups achieved similar peak effects during the single-dose phase. Individuals treated with rofecoxib demonstrated a longer duration of analgesic effect than those treated with a single dose of oxycodone/acetaminophen. Patients on active treatment demonstrated better efficacy than patients on placebo on these prespecified endpoints ( p < 0.001 for both comparisons). Fewer rofecoxib than oxycodone/acetaminophen patients experienced adverse events (47.9 vs 75.8%, p < 0.001), including nausea (19.0 vs 42.5%, p < 0.001), vomiting (9.9 vs 24.2%, p < 0.01), and dizziness (7.4 vs 31.7%, p < 0.001). Conclusion: Patients treated with a single dose of rofecoxib 50 mg achieved an overall analgesic effect at least as effective as patients treated with a single-dose of oxycodone/acetaminophen 10/650 mg over 6 h and multidose oxycodone/acetaminophen over 24 h, with fewer adverse experiences of nausea ( p < 0.001), vomiting ( p < 0.01), and dizziness ( p < 0.001).
Lower Fat Intake Is Associated With Lower Weight and Cholesterol at 4 Months in Adults With Impaired Glucose Metabolism

Several large clinical trials in diverse high-risk populations have demonstrated that participation in intensive lifestyle interventions can reduce prediabetes or prevent its progression to type 2 diabetes.1–5 In the largest of these clinical trials, the Diabetes Prevention Program (DPP), significant differences in dietary intake (e.g., lower percentage of energy from fat, higher number of fruit and vegetable servings, and higher fiber content) were observed in participants in the lifestyle intervention group compared to those in the metformin and placebo groups at 1 year after randomization.6 Furthermore, achievement and maintenance of weight loss was associated with self-monitoring of dietary fat intake and meeting physical activity goals.7 Although translation of a structured diabetes prevention program, including dietary changes, moderate-level physical activity, and weight loss of 5–7% of body weight, has been successful in various community settings,8–17 only one study to date has examined the individual-level factors associated with successful achievement and maintenance of weight loss.13,17 This study used trained health professionals as lifestyle coaches. In contrast, our previous research translating the DPP used trained YMCA fitness or wellness instructors and has proven successful in achieving and maintaining meaningful levels of weight loss and reductions in overall cardiometabolic risk for adults with abnormal glucose metabolism.8,14 The Diabetes Education & Prevention with a Lifestyle Intervention Offered at the YMCA (DEPLOY) study was designed to achieve modest weight loss, in part through reduced intake of total dietary calories beginning with strategies to reduce dietary fat. In this article, we explore whether change in nutrition intake, particularly in percentage of energy from dietary fat (PEF), is associated with observed changes in our primary outcomes—total cholesterol and body weight—after participating in the DEPLOY study. DEPLOY study methods have been described extensively in a …
Who Takes You to the Dance? How Partners’ Institutional Logics Influence Innovation in Young Firms

Drawing on institutional theory, we examine how the institutional logics—taken-for granted norms, structures, and practices—of different types of funding partners influence young firms and their search for innovations. We test our hypotheses in a longitudinal study of a complete population of ventures in the minimally invasive surgical device industry in the U.S., supplemented by interviews with industry informants. We find that types of funding partners vary significantly from one another: they all provide resources, but their institutional logics differ. Venture capitalists (VCs) pick young firms with significant patented technologies and help firms launch products, and high-status VCs strengthen both the patenting and product innovations of young firms. Corporate venture capitalists and government agencies also select patent-intensive firms but are less effective than VCs in helping ventures during the relationship because, though these partners often have impressive technical and commercial resources for innovation, their institutional logics constrain how effectively young firms can access their resources. Relative to other types of funding partners, VCs have a closer advisor relationship with the venture; greater power, influence, and access to resources; better-paced and more-motivating milestones; and better understanding of the commercialization process. Our results extend the institutional logics literature to interorganizational relationships and suggest that the choice among types of funding partners may have unanticipated effects on firms’ innovation beyond the financial resources gained through the relationship.
Dual role of Atg1 in regulation of autophagy-specific PAS assembly in Saccharomyces cerevisiae

Most autophagy-related (Atg) proteins are assembled at the phagophore assembly site or pre-autophagosomal structure (PAS), which is a potential site for vesicle formation during vegetative or starvation conditions. To understand the initial step of vesicle formation, it is important to know how Atg proteins are recruited to the PAS. Atg11 facilitates PAS assembly for the cytoplasm to vacuole targeting (Cvt) pathway in vegetative conditions. To examine autophagy-specific PAS formation, an ATG11 deletion mutant was used to eliminate the PAS formation that occurs in vegetative conditions. We found that Atg1, Atg13 and Atg17 play a similar role for PAS formation under autophagy-inducing conditions as seen for Atg11 during vegetative growth. In particular, Atg1 is proposed to have dual roles for autophagy-specific PAS recruitment. Atg1 plays a structural role for efficient recruitment of Atg proteins to the PAS, which is mediated by interaction with Atg13 and Atg17. In contrast, Atg1 kinase activity is needed for dissociation of Atg proteins from the PAS during autophagy inducing conditions, a function which is also critical for autophagy activity. Addendum to: Cheong H, Nair U, Geng J Klionsky DK. The Atg1 kinase complex Is involved in the regulation of protein recruitment to initiate sequestering vesicle formation for nonspecific autophagy in Saccharomyces cerevisiae. Mol Biol Cell 2008; 19:668-81.
PENGARUH PENYAJIAN LAPORAN KEUANGAN DAERAH DAN AKSESIBILITAS LAPORAN KEUANGAN DAERAH TERHADAP AKUNTABILITAS PENGELOLAAN KEUANGAN DAERAH ( Studi Pada SKPD Pemerintah Kabupaten Rokan Hilir)

This study aims to examine the influence of regional financial statement and financial statement accessibility on financial management accountability. The populations in this study were officials echelon II dan III which consist of heads of SKPD, SKPD finance department expenditures and receipts SKPD in district Rokan Hilir. The sampling method using purposive sampling method. The data of this research using primary data directly through questionnaire and analyzed using SPSS version 16. The data were analyzed to test the hypothesis using multiple linear regression analysis approach. The results of this study showed regional financial statement and accesibility of financial management accountability effect on financial management. Keywords: regional financial statement, accessibility, and accountability
Randomized controlled trial of maternal omega-3 long-chain PUFA supplementation during pregnancy and early childhood development of attention, working memory, and inhibitory control.

BACKGROUND Docosahexaenoic acid (DHA) accumulates in the hippocampus and frontal lobes of the fetal brain during the last trimester of pregnancy. These areas of the brain contribute to attention and working memory and inhibitory control (WMIC). OBJECTIVE We evaluated the effect of maternal omega-3 (n-3) long-chain polyunsaturated fatty acid supplementation in pregnancy on child attention and WMIC. DESIGN A total of 185 term-born children of mothers who were randomly allocated to consume 800 mg DHA/d (treatment) or a placebo (control) from ∼20 wk of gestation until birth were assessed with multiple measures of attention and WMIC at a mean (± SD) of 27 ± 2 mo. Primary outcomes were the average time it took to be distracted when playing with a toy (distractibility) and the accuracy of remembering a new hiding location while inhibiting a learned response to search in the previous location (WMIC). RESULTS Assessments were completed by 81 children in the treatment group (mean ± SD age: 835 ± 50.4 d) and 77 children in the control group (839 ± 65.6 d). There was no effect of supplementation on primary outcomes [distractibility mean difference: -0.2 s (95% CI: -0.7, 0.4 s); WMIC mean difference: 8.9 mm (95% CI: -10.6, 28.3 mm)]. There was no difference between DHA-supplemented and control groups except that treatment-group children looked away from the toys fewer times than controls when presented with multiple toys competing for attention but less accurately remembered a repeated hiding location. These secondary effects were not consistent with any other outcomes and may have been a result of chance. Cord plasma DHA was not consistently associated with attention and WMIC. CONCLUSION Maternal DHA supplementation during pregnancy does not enhance attention or WMIC in term-born preschoolers. The DHA for Maternal and Infant Outcomes trial was registered at www.anzctr. org.au as ACTRN1260500056906.
Short-term responses of Dutch vacationers to a sharp increase in transport costs

This paper investigates vacationers’ short-term responses to a sharp increase in transport costs. It aims to (1) acquire an understanding of the relative popularity of the different types of responses among vacationers and (2) explore whether there are distinct market segments of vacationers that respond differently to a sharp increase in transport costs. Data are obtained from a novel, tailor-made questionnaire which was done in the Netherlands in 2012. Results show that no single response is either very popular or unpopular. Furthermore, using latent class cluster analysis, four market segments (classes) of vacationers are identified that have markedly distinct response patterns. It was found that Age and Income explain class membership.
Th22 cell accumulation is associated with colorectal cancer development.

AIM To investigate the expression of Th22 cells and related cytokines in colorectal cancer (CRC) tissues, and the probably mechanism. METHODS CRC tumor and paratumor tissues were collected to detect the expression levels of Th22 cells and of related cytokines by immunohistochemistry, flow cytometry and real-time quantitative polymerase chain reaction (RT-qPCR). Interleukin (IL)-22 alone or with a STAT3 inhibitor was co-cultured with RKO cells in vitro to study the effects of IL-22 on colon cancer cells. IL-22 alone or with a STAT3 inhibitor was injected into a BALB/c nude mouse model with subcutaneously transplanted RKO cells to study the effects of IL-22 on colon cancer growth. RESULTS The percentage of Th22 cells in the CD4(+) T subset was significantly higher in tumor tissues compared with that in paratumor tissues (1.47% ± 0.083% vs 1.23% ± 0.077%, P < 0.05) as determined by flow cytometry. RT-qPCR analysis revealed that the mRNA expression levels of IL-22, aryl hydrocarbon receptor, CCL20 and CCL22 were significantly higher in tumor tissues compared with those in paratumor tissues. CCL27 mRNA also displayed a higher expression level in tumor tissues compared with that in paratumor tissues; however, these levels were not significantly different (2.58 ± 0.93 vs 2.30 ± 0.78, P > 0.05). IL-22 enhanced colon cancer cell proliferation in vitro and displayed anti-apoptotic effects; these effects were blocked by adding a STAT3 inhibitor. IL-22 promoted tumor growth in BALB/c nude mice; however, this effect was reversed by adding a STAT3 inhibitor. CONCLUSION Th22 cells that accumulate in CRC may be associated with the chemotactic effect of the tumor microenvironment. IL-22 is associated with CRC development, most likely via STAT3 activation.
Impaired cue identification and intention retrieval underlie prospective memory deficits in patients with first-episode schizophrenia

Objective: Schizophrenia is associated with impairment in prospective memory, the ability to remember to carry out an intended action in the future. It has been established that cue identification (detection of the cue event signaling that an intended action should be performed) and intention retrieval (retrieval of an intention from long-term memory following the recognition of a prospective cue) are two important processes underlying prospective memory. The purpose of this study was to examine prospective memory deficit and underlying cognitive processes in patients with first-episode schizophrenia. Methods: This study examined cue identification and intention retrieval components of event-based prospective memory using a dual-task paradigm in 30 patients with first-episode schizophrenia and 30 healthy controls. All participants were also administered a set of tests assessing working memory and retrospective memory. Results: Both cue identification and intention retrieval were impaired in patients with first-episode schizophrenia compared with healthy controls (ps < 0.05), with a large effect size for cue identification (Cohen’s d = 0.98) and a medium effect size for intention retrieval (Cohen’s d = 0.62). After controlling for working memory and retrospective memory, the difference in cue identification between patients and healthy controls remained significant. However, the difference in intention retrieval between the two groups was no longer significant. In addition, there was a significant inverse relationship between cue identification and negative symptoms (r = −0.446, p = 0.013) in the patient group. Conclusion: These findings suggest that both cue identification and intention retrieval in event-based prospective memory are impaired in patients with first-episode schizophrenia. Cue identification and intention retrieval could be potentially used as biomarkers for early detection and treatment prognosis of schizophrenia. In addition, addressing cue identification deficit through cognitive enhancement training may potentially improve negative symptoms as well.
Towards a contingency approach with whitelist- and blacklist-based anti-phishing applications: what do usability tests indicate?

In web browsers, a variety of anti-phishing tools and technologies are available to assist users to identify phishing attempts and potentially harmful pages. Such anti-phishing tools and technologies provide Internet users with essential information, such as warnings of spoofed pages. To determine how well users are able to recognise and identify phishing web pages with anti-phishing tools, we designed and conducted usability tests for two types of phishing-detection applications: blacklist-based and whitelist-based anti-phishing toolbars. The research results mainly indicate no significant performance differences between the application types. We also observed that, in many web browsing cases, a significant amount of useful and practical information for users is absent, such as information explaining professional web page security certificates. Such certificates are crucial in ensuring user privacy and protection. We also found other deficiencies in web identities in web pages and web browsers that present challenges to the design of anti-phishing toolbars. These challenges will require more professional, illustrative, instructional, and reliable information for users to facilitate user verification of the authenticity of web pages and their content.
Influence of machining parameters on surface roughness and dry friction

Article history: Received 6 October, 2015 Accepted 7 March 2016 Available online 8 March 2016 Dry friction depends on the surface topography which, in turn, is governed by machining parameters in addition to several other factors,. Therefore, in order to establish a qualitative relationship among these factors, the surface roughness and coefficient of static friction are measured for specimens machined on lathe and shaper machines with different values of machining parameters. For the case of lathe, the measured Ra value is found to increase with increase in feed rate and depth of cut, whereas, a marginal decrease is observed with increasing spindle speed. Similar results with respect to cutting speed have been obtained for the case of shaper machine. On the other hand, the coefficient of static friction, measured on steel substrate using inclined plane method, is found to decrease with increasing Ra values for both the specimen types. © 2016 Growing Science Ltd. All rights reserved.
Disruptions in Women's Self-Promotion: The Backlash Avoidance Model 1

Women experience social and economic penalties (i.e., backlash) for self-promotion, a behavior that violates female gender stereotypes yet is necessary for professional success. However, it is unknown whether and how the threat of backlash interferes with women's ability to self-promote. The present research examined the effects of fear of backlash and self-regulatory mode on women's self-promotion success by testing the backlash avoidance model (BAM), a model designed to account for disruptions in women's self-promotion. Two studies employing U.S. undergraduate samples examined self-promotion both in a live interview and written context. Results supported the BAM's predictions that self-promoting women's fear of backlash inhibits activation of a goal-focused, locomotive regulatory mode, which subsequently interferes with self-promotion success. This process was not evident for self-promoting men (Study 1) or peer-promoting women (Study 2), groups who demonstrated reliably more promotion success than self-promoting women. The influence of women's endorsement of communal stereotypes and their perceived entitlement were also investigated. Implications for women's self-promotion, gender stereotyping, and workplace parity are discussed.
Allergic Inflammation Leads to Neuropathic Pain via Glial Cell Activation

Allergic and atopic disorders have increased over the past few decades and have been associated with neuropsychiatric conditions, such as autism spectrum disorder and asthmatic amyotrophy. Myelitis presenting with neuropathic pain can occur in patients with atopic disorder; however, the relationship between allergic inflammation and neuropathic pain, and the underlying mechanism, remains to be established. We studied whether allergic inflammation affects the spinal nociceptive system. We found that mice with asthma, atopic dermatitis, or atopic diathesis had widespread and significantly more activated microglia and astroglia in the spinal cord than those without atopy, and displayed tactile allodynia. Microarray analysis of isolated microglia revealed a dysregulated phenotype showing upregulation of M1 macrophage markers and downregulation of M2 markers in atopic mice. Among the cell surface protein genes, endothelin receptor type B (EDNRB) was most upregulated. Immunohistochemical analysis revealed that EDNRB expression was enhanced in microglia and astroglia, whereas endothelin-1, an EDNRB ligand, was increased in serum, lungs, and epidermis of atopic mice. No EDNRA expression was found in the spinal cord. Expression of FBJ murine osteosarcoma viral oncogene homolog B was significantly higher in the dorsal horn neurons of asthma mice than nonatopic mice. The EDNRB antagonist BQ788 abolished glial and neural activation and allodynia. We found increased serum endothelin-1 in atopic patients with myelitis and neuropathic pain, and activation of spinal microglia and astroglia with EDNRB upregulation in an autopsied case. These results suggest that allergic inflammation induces diffuse glial activation, influencing the nociceptive system via the EDNRB pathway. SIGNIFICANCE STATEMENT The prevalence of allergic disorders has markedly increased over the past few decades. Allergic disorders are associated with neuropsychiatric conditions; however, the relationship between allergic inflammation and CNS complications is unknown. A peculiar myelitis presenting with persistent neuropathic pain has been reported in patients with allergic disorders. We studied how atopy exerts substantial influence on the nociceptive system. We found that mice with allergic disorders had severe allodynia with activated astroglia and microglia, and showed marked upregulation of endothelin-1 (ET-1) receptor type B (EDNRB) in the spinal cord. A selective EDNRB antagonist prevented allodynia and glial activation. Our findings suggest a novel mechanism whereby atopy induces glial activation and neuropathic pain via an ET-1/EDNRB pathway.