Miracle-dz/UniFAR-FTUs huggingface dataset:
Identification of lysosomal Npc1‐binding proteins: Cathepsin D activity is regulated by NPC1

Niemann–Pick type C (NPC) disease is an inherited lysosomal storage disorder, characterized by severe neurodegeneration. It is mostly produced by mutations in the NPC1 gene, encoding for a protein of the late endosomes/lysosomes membrane, involved in cholesterol metabolism. However, the specific role of this protein in NPC disease still remains unknown. We aimed to identify Npc1‐binding proteins in order to define new putative NPC1 lysosomal functions. By affinity chromatography using an Npc1 peptide (amino acids 1032–1066 of loop I), as bait, we fished 31 lysosomal proteins subsequently identified by LC‐MS/MS. Most of them were involved in proteolysis and lipid catabolism and included the protease cathepsin D. Cathepsin D and NPC1 interaction was validated by immunoprecipitation and the functional relevance of this interaction was studied. We found that fibroblasts from NPC patients with low levels of NPC1 protein have high amounts of procathepsin D but reduced quantities of the mature protein, thus showing a diminished cathepsin D activity. The increase of NPC1 protein levels in NPC cells by treatment with the proteasome inhibitor bortezomib, induced an elevation of cathepsin D activity. All these results suggest a new lysosomal function of NPC1 as a regulator of cathepsin D processing and activity.
Climatic and seasonal influences on radon time series in an environment of low anthropogenic activity

Between June 2003 and March 2008, radon concentrations were measured at hourly intervals in an environmentally-stable, rarely-visited basement, subject to minimal anthropogenic activity. Measurement periods totalled 1025 days (59% of the total investigation period), the longest continuous measurement period and the longest interval between measurement periods being 335 days (19%) and 271 days (15%) respectively. Mean daily, monthly (calendar) and annual concentrations were generated. For each calendar month, global averages (mean of measurements in corresponding months of at least three separate years during the study) were derived. Similar means were generated from meteorological data collected 10km from the measurement site. Overall mean and standard deviation (SD) radon concentrations were 73.0 Bq.m-3 (95% CI 0.8 Bq.m-3) and 62.7 Bq.m-3 respectively, corresponding mean and SD internal temperatures being 26.2 C (95% CI 0.02 C) and 1.7 C, respectively. Cross-correlation confirmed monthly mean radon concentrations as essentially independent of external temperature, atmospheric pressure, wind-speed, rainfall and relative humidity, with Correlation Coefficients, R2, all less than 0.06. Statistically-derived Seasonal Correction Factors (SCFs) are conventionally used to convert a radon concentration measurement over a sub-year period to a notional annual mean. It is recognised that this approach is not universally valid, a recent proposal using mean external temperature to derive a localised SCF, subject to positive temperature difference between the interior of the building under investigation and the environment. To test this, SCF sets were derived using monthly mean radon concentration, external temperature and internal/external temperature difference, using mean variance between these and the UK SCF set to quantise goodness-of-fit. Deriving SCFs from external temperature provides significantly better fit to the UK SCF set (mean variance = 0.09) than do radon concentration or temperature difference (mean variance = 0.48 and 0.47 respectively). Details of the experimental method and analysis results will be presented, together with further observations on seasonal variability of radon concentrations.
EFFECT OF CORPORATE SOCIAL RESPONSIBILITY (CSR), PROFITABILITY, AND PROFIT MANAGEMENT ON TAX EVASION

This study examines the effect of Corporate Social Responsibility (CSR), profitability, and profit management on tax evasion. We use manufacture company’s subsector food and beverage listed on the Indonesia Stock Exchange (BEI) during 2012-2016, based on purposive sampling method was obtained 8 companies. The indicators disclosure of CSR is using Global Reporting Initiative (GRI) guideline. Variable profitability is measured by a ratio of ROA, and profit management is measured by discretionary accrual. The dependent variable is proxy by CETR. We use multiple linear regression method. The result shows that the CSR and profitability have asignificant influenceon tax evasion. profit management does not have a significant influence on tax evasion.
Ondes internes en océanographie et cristaux photoniques : une approche mathématique

Ce memoire est compose de deux parties independantes. Si les deux sujets traites sont de nature differente, l’etude asymptotique du probleme est a chaque fois au centre de la reflexion. Dans la premiere partie, nous nous interessons au comportement d’un systeme compose de deux fluides non miscibles, soumis a la seule force de gravite. Un tel systeme est utilise en oceanographie, afin de modeliser une etendue d’eau de densite variable. On commence par ecrire sous forme agreable les equations d’evolution gouvernant le systeme. Ensuite, on developpe une panoplie de modeles asymptotiques, dans les regimes d’eau peu profonde – ou l’on suppose que la profondeur des couches de fluide est petite devant la longueur d’onde caracteristique a l’interface – et d’ondes longues – ou l’on ajoute une hypothese de petitesse des deformations a la surface et a l’interface. Ces modeles sont rigoureusement justifies, par des resultats de coherence ou de convergence. Finalement, on s’interesse particulierement au phenomene d’eaux mortes, qui se manifeste par une forte resistance a l’avancement subie par un corps naviguant dans des eaux stratifiees. Cette resistance est une consequence de l’energie depensee par le corps pour generer une onde a l’interface entre les deux couches de fluide. La encore, des modeles asymptotiques sont construits, justifies rigoureusement et simules numeriquement. Une telle etude nous permet de predire dans quelles situations le phenomene d’eaux mortes se manifeste. La deuxieme partie est dediee a l’etude de la propagation des ondes dans un milieu non-homogene. La motivation de cette etude se situe dans les cristaux photoniques, dont les proprietes de structure se repercutent sur la propagation des rayons lumineux. Plus particulierement, nous nous interessons a l’influence de la presence de defauts dans le materiau, modelises par des singularites et/ou des discontinuites dans la microstructure. On montre que ces interfaces ont un effet predominant sur les proprietes asymptotiques du materiau – notamment le coefficient de transmission – lorsque la longueur caracteristique de la microstructure tend vers zero.
Comparison of Desarda versus Modified Bassini inguinal Hernia Repair: A Randomized controlled trial.

Background: Although the tension free inguinal hernia repair with a mesh is the standard technique in many developed countries, its use has remained low in the developing world due to the initial cost of the mesh. The most commonly used method in Mulago hospital is modified Bassini. The main aim of this study was to compare the short-term out come of Desarda’s versus modified Bassini inguinal hernia repair. Methods: One hundred and eight patients each with a unilateral, primary, reducible inguinal hernia were recruited through the surgical out patients department. Patients were randomly assigned to either the Desarda’s or Modified Bassini inguinal hernia repair. Postoperative pain was assessed using a visual analogue scale 1 to 2 hours after the operation, on the 3 rd post operative day (POD) and again on the 7 th POD. The gait was assessed on the 7 th POD for all the patients and again on the 14 th POD for those patients who had not attained their normal gait or had any postoperative wound complications on the 7 th POD. Results: Of the 108 patients recruited, 88 (81%) were male and 20(19%) female. 3 patients were lost to follow up and 1 had an emergency laparotomy. The mean POD for resumption of normal gait was 3.62 for both methods. There was no statistically significant difference between the days of resumption of normal gait between the two methods (p-value = 0.94). There were no major complications using either of the two methods. There was no statistically significant difference between the two methods as regards the postoperative pain patterns 2 hours postoperative, on 3 rd POD and on the 7 th POD. Conclusion: There is no difference in short-term outcome between Desarda and modified Bassini inguinal hernia repair as regards resumption of normal gait and patterns of pain.
Global Warming — Scientific Facts, Problems and Possible Scenarios

Climatology is a branch of atmospheric sciences concerned with the study of climates of the Earth and analyzing the causes and practical consequences of climatic changes. Until the 19th century climatology was closely linked with meteorology. The concept of climate appeared first in ancient Greece. Aristotle (384–322 BC) wrote “Meteorologica” – the first scientific book about the atmospheric (meteorological and climatic) phenomena. The understanding of climate by Aristotle and Hippocrates (460–377 BC) remained very influential until well into the 18th century [38]. The medieval Chinese scientist Shen Kuo (1031–1095) was probably the first person who asserted that climate can change in the course of time. Enlightenment in Europe gave a new pulse to the development of both weather and climate research. The invention of meteorological devices – thermometer (Galileo in 1603), mercury barometer (Torricelli in 1643), barometer-aneroid (Leibnitz in 1700) – opened a new era in meteorology. Appreciable milestones in both meteorology and climatology were reached in the 19th century. In 1817 A. Humboldt (1769–1859) – one of the pioneers in scientific climatology – constructed the first map of global annual isotherms using the data from 57 weather stations. In 1848 H.W. Dove (1803–1879) constructed maps of the isotherms of January and July. The first isobars based on data on prevailing winds of the entire globe were constructed by Buhan in 1869. Francis Galton (1822–1911) invented the term anticyclone. Moreover, in 1896 S. Arrhenius (1859–1927) claimed that fossil fuel combustion may eventually result in a global warming. He proposed a relation between atmospheric carbon dioxide concentrations and global tempera‐ ture. These among numerous other findings laid the foundation for modern climatology.
Preclinical toxicological assessment of a phytotherapeutic product – CPV (based on dry extracts of Crataegus oxyacantha L., Passiflora incarnata L., and Valeriana officinalis L.)

Associations of plants have been widely used, for centuries, in Ayurveda and in Chinese medicine and have been increasingly acknowledged in Western medicine. The objective of this study is to assess the level of toxicity of an association of three plants: Crataegus oxyacantha, Passiflora incarnata, and Valeriana officinalis (CPV extract). This association was administered to rats, mice, and dogs, both acute and chronically for 180 days. The tests used in the acute experiments were: observational pharmacological screening, LD50, motor coordination and motor activity. Chronic tests carried out were: weight gain/loss and behavioral parameters in rats and in mice; estrus cycle, effects on fertility, and teratogenic studies in rats and of mutagenic features in mice, in addition to the Ames test. The following parameters were assessed in dogs: weight gain/loss, general physical conditions, water/food consumption and anatomopathological examination of the organs subsequent to the 180 days of treatment. All of the results were negative, showing that CPV administered in high doses and over a long period of time presents no toxicity, suggestive of the fact that this is an association devoid of risk for human beings. Copyright © 2008 John Wiley & Sons, Ltd.
Accurate drain conductance modeling for distortion analysis in MOSFETs

Present compact circuit-level MOSFET models fail to accurately describe distortion effects, which is partly due to an imprecise modeling of conductance. A new MOS model has been developed which gives accurate results for distortion analysis, and incorporates a more precise description of various physical phenomena such as velocity saturation, channel length modulation, static feedback and self-heating.
Deep-vein thrombosis.

Credit for fundamental studies leading to our current understanding of deep-vein thrombosis should be given to Bauer, who used phlebography to diagnose deep-vein thrombosis complicating fractures of the tibia,1 and to Sevitt and Gallagher for their autopsy-based studies of the prevalence of venous thromboembolism in patients with other injuries2,3. The development of objective methods for the diagnosis of deep-vein thrombosis has facilitated the investigation of its natural history and has provided a rational basis for its prevention and treatment. Diagnosis Most venous thrombi are clinically silent when they are first detectable by objective methods,2,4 probably because they .
Determinants of Private Saving: A Case of Pakistan

This paper investigates the impact of demographic factors like age, income, dependency ratio, education of males and females and the economic factor of financial depth on household savings in Pakistan. The results were obtained for time series data of 1975-2008 by applying cointegration analysis. The study concludes that increase in per capita income, expected age, deepening of financial system, increase in years of education of both males and females are positively associated with higher saving rate but increase in dependency ratio has negative impact on saving rate. So in order to increase the rate of savings, there is a need to focus on the deepening of financial system on one hand, and improving the education of males and females, increasing the level of income and expected age and reducing the dependency ratio on the other hand.
Evaluation of DPPH Free Radical Scavenging Activity of Various Extracts of Ligularia fischeri In Vitro: a Case Study of Shaanxi Region

A comparison study of the antioxidative activities was conducted in vitro on the different extracts from the different origins, harvest seasons, solvents and plant parts of Ligularia fischeri grown in Shaanxi. Different parts of L. fischeri, such as roots and rhizomes, stems, leaves, scapes and fruits, were extracted by an ultrasonic- assisted extraction method with water, 95% ethanol, n-butanol, ethyl acetate and chloroform, respectively. Diphenyl picryl hydrazyl method was used to evaluate the antioxidative activities of these extracts. The result of antioxidative study showed that L. fischeri picked in September showed higher activities than that those picked in October. The extracts of L. fischeri from different solvents presented different free radical scavenging activities: water>95% ethanol>n-butanol>ethyl acetate>chloroform. The different herbal parts also showed the different antioxidative activities. The present work will provide a reference for the further research and exploitation of L. fischeri.
Upper Eyelid Anatomy: An Update

Eyelid surgery necessitates a thorough knowledge of eyelid anatomy. Recent contributions to the literature have significantly advanced our understanding of eyelid anatomy. In this review, we present an update of the anatomy and the implications for upper eyelid surgery. Aspects to be covered include the levator aponeurosis, Müller's muscle, lamina propria mucosae of conjunctiva, orbital septum, myoneural junction of the levator palpebrae superioris muscle, adipose tissue, and the ligament system.
In “likes” we trust: likes, disclosures and firm-serving motives on social media

Purpose This paper aims to examine when and how the number of “likes” can exert significant influence on consumer evaluations of social media advertising. It sheds a novel perspective on how social media “likes”, advertising disclosures and the presence of firm-serving motives influence advertising effectiveness. Design/methodology/approach Study 1 examines how the number of “likes” influences consumer attitudes towards the sponsoring brand by strengthening advertising credibility, when social media ads are effectively (vs non-effectively) disclosed. Study 2 further establishes how the influence of the number of “likes” for effectively disclosed ads varies depending on whether the company states (vs does not state) its firm-serving motives. Findings The authors found that a social media ad displayed with a higher number of “likes” is perceived to be more credible, which can then yield more positive attitudes towards the brand. However, the use of effective disclosures moderates this relationship. To offset this effect, companies can restore the value of “likes” by stating their firm-serving motives openly when they develop social media advertising messages. Research limitations/implications The study offers a novel perspective on how consumers evaluate the number of displayed “likes” in the context of other social media features. Practical implications The study shows how social media marketers can become more effective in taking advantage of the number of “likes” that they accumulate on social networking site platforms. Originality/value The study illustrates a novel mechanism behind how and when the number of “likes” can influence the effectiveness of social media advertising.
Availing entitlements under Janani Shishu Suraksha Karyakram in Tamil Nadu: a reality

Globally, on any given day, a staggering 830 women die from pregnancy and childbearing related causes. World Health Organization (WHO) estimates that of the overall maternal mortality burden, a staggering 99% is contributed by developing nations. India, over the past 20 years has seen a gradual decline in maternal mortality ratio (MMR) and the figure stood at 174 maternal deaths per 100,000 live births in 2015. IMR in the year 2015 was 32 deaths per 1000 live births worldwide and in India it was 38 per 1000 live births. This decline is expected to take India to the target MMR of 100 deaths per 100,000 live births and IMR of 28 per 1000 live births as envisaged by the National Health Policy of India 2017.
Different Types of Laser use in Teeth Bleaching

The study of the present work aimed to compare betw een Laser and non laser systems in teeth bleaching, It be found that laser system is better than non laser systems and achieve a better result by selective radiation which can decrease the expos ure time during bleaching hence reduces that intra-pulpal temperature. There are other lasers th at have been tested for teeth whitening as Alexandrite and Nd:YAG. However, Er:YAG and diode l asers are the most type of lasers used in tooth bleaching specifically the recent types as to uchwhite by fotona Er:YAG. The Er:YAG light does not penetrate through the gel and consequently does not directly heat the hard dental tissue or the pulp. The most effect Laser is touchwhite by Fotona Er:YAG as it least effect the dental pulp
The Usefulness and Applicability of a Basic Headache Diary Before First Consultation: Results of a Pilot Study Conducted In Two Centres

We tested the usefulness and applicability of a simplified headache diary in the diagnosis of migraine (M), tension-type headache (TTH) and medication overuse headache (MOH). The diary was given to headache patients before their first consultation at the headache centre. Seventy-six naive headache patients completed the study. Their understanding of the diary proved highly satisfactory. The patients' level of compliance was also good, with 71± returning the diary completely filled in. The data entered in the diary were deemed complete for the diagnostic purpose in 93± of cases. The level of agreement between headache information gathered through clinical interview and the headache diary was satisfactory. When comparing the diary with the clinical interview, sensitivity was 92± for M, 75± for TTH and MOH. Specificity was 58± for M and TTH, 87± for MOH. Combined use of a diagnostic diary and clinical interview is recommended from the first consultation for headache.
Thinking outside the Osp(G)—kinase activation by E2‐ubiquitin

OspG is a secreted effector kinase from the human pathogen Shigella that is required for the reduction of immune responses during Shigella infection. A new study in The EMBO Journal provides a co‐crystal structure of OspG bound to UbcH5c~Ub, revealing how a bacterial kinase can be activated by the host ubiquitin conjugation machinery. These results provide molecular insight into an enigmatic microbial virulence factor that thwarts the host immune surveillance system to cause disease.
Banking regulation and supervision in Nigeria : an analysis of the effects of banking reforms on bank performance and financial stability

This study analyses the effects of banking regulation and supervision on the performance and stability of Nigerian deposit money banks (DMBs) over the period of 2000 – 2013. Research in the area of banking regulation and supervision has gained considerable attention since the episode of the global financial crisis that started in the second half of 2007. It is against the background that both international and national regulators are continuously introducing new rules and guidelines for banking institutions to ensure sound banking systems that this study analyses the Nigerian experience. On that account, the Nigerian banking sector went through two banking reforms in 2005 and 2009 and this study employs a mixed methods approach to ascertain the effects of the reforms on the performance of Nigerian deposit money banks. This thesis adopts the use of content analysis of interview responses to examine the initiatives employed by both Nigerian regulators and bank managements towards ensuring healthy banking practices. More so, the DEA window analysis is employed in this thesis to trace the efficiency level of individual deposit money banks through the 2005 and 2009 banking reforms and the global financial crisis. While multiple regression estimations are adopted to ascertain the effects of capital adequacy, asset quality, management quality, earning ability, liquidity, sensitivity to risk, bank size, and GDP on bank efficiency, bank performance, and financial stability. The results suggest that the two Nigerian reforms led to a general increase in the performance and efficiency of Nigerian DMBs. However, the 2005 banking reforms was unable to shield the Nigerian banking sector from the adverse effect of the global financial crisis. Additionally, evidence suggests that Nigerian DMBs recovered in the post-global financial crisis period in reaction to regulatory initiatives. The results also show that resolution techniques adopted by Nigerian regulators prevented the failure of several Nigerian DMBs during the global financial crisis. This also found that DMBs fortified their internal control practices in line with the 2009 banking to reduce the build-up of non-performing loans as it was the case after the 2005 banking reforms when there was excess liquidity. However, even as the reforms led to increased efficiency scores and performance, the results show that capital injections whether in the form of capital requirement increase or bailouts do not guarantee sustained efficiency and stability. To that end, this study recommended increased surveillance of DMBs and adoption of qualitative and statistical assessments of bank performance.