Miracle-dz/UniFAR-FTUs huggingface dataset:
Age Differences in Autobiographical Memories of Negative Events

This study examined whether older adults recollect autobiographical memories of negative events so as to minimize unpleasant emotions to a greater extent than do younger adults. A sample of healthy older adults (N = 126) and younger adults (N = 119) completed the Autobiographical Memory Questionnaire and a measure of PTSD symptoms in response to their most negative recalled event. Results supported the hypothesis that older adults rated their negative memories as having: 1) less of a sense of traveling back to the time the event occurred, 2) less associated visceral emotional reactions, 3) fewer associated negative emotions, and 4) fewer PTSD symptoms, all relative to younger adults. In addition, older adults exhibited higher ratings of belief in accuracy, higher ratings that the memory comes as a coherent story, and more associated positive emotions, again all relative to younger adults. After controlling for differences between the types of events younger and older adults reported and how long ago the event occurred, the above age differences remained statistically significant, though the effect sizes were attenuated in some cases. These results are consistent in their support for the positivity effect, and suggest that older adults modify their recollections of negative events in a manner that is emotionally adaptive for them.
Gastrointestinal microbiota of wild and inbred individuals of two house mouse subspecies assessed using high‐throughput parallel pyrosequencing

The effects of gastrointestinal tract microbiota (GTM) on host physiology and health have been the subject of considerable interest in recent years. While a variety of captive bred species have been used in experiments, the extent to which GTM of captive and/or inbred individuals resembles natural composition and variation in wild populations is poorly understood. Using 454 pyrosequencing, we performed 16S rDNA GTM barcoding for 30 wild house mice (Mus musculus) and wild‐derived inbred strain mice belonging to two subspecies (M. m. musculus and M. m. domesticus). Sequenced individuals were selected according to a 2 × 2 experimental design: wild (14) vs. inbred origin (16) and M. m. musculus (15) vs. M. m. domesticus (15). We compared alpha diversity (i.e. number of operational taxonomic units – OTUs), beta diversity (i.e. interindividual variability) and microbiota composition across the four groups. We found no difference between M. m. musculus and M. m. domesticus subspecies, suggesting low effect of genetic differentiation between these two subspecies on GTM structure. Both inbred and wild populations showed the same level of microbial alpha and beta diversity; however, we found strong differentiation in microbiota composition between wild and inbred populations. Relative abundance of ~ 16% of OTUs differed significantly between wild and inbred individuals. As laboratory mice represent the most abundant model for studying the effects of gut microbiota on host metabolism, immunity and neurology, we suggest that the distinctness of laboratory‐kept mouse microbiota, which differs from wild mouse microbiota, needs to be considered in future biomedical research.
Changes in lipid diffusibility in the hamster sperm head plasma membrane during capacitation in vivo and in vitro

The technique of fluorescence recovery after photobleaching (FRAP) was employed on spermatozoa labeled with the fluorescent lipid analogue C14diI to provide two measures of lateral diffusion in the plane of the sperm plasma membrane during capacitation in vivo and in vitro: the diffusion coefficient (D) for C14diI and the fraction of C14diI that is free to diffuse (%R) within the domain. To evaluate changes in lipid diffusibility during capacitation in vivo, spermatozoa were recovered from the uterus within 30 min after ejaculation or from the oviduct at 2, 4, 6 and 8 hr after mating. To compare the changes which occur in vivo with those which occur during capacitation in vitro, caudal epididymal spermatozoa were incubated under capacitating or non‐capacitating (control) conditions for 4 hr. Although transient changes in D occurred during the course of capacitation, there was no net change in D for either anterior (AH) or posterior head (PH) domains following capacitation in vitro or in vivo. Significant differences in the lipid diffusion coefficient between the two head domains were observed during the course of capacitation. A transient decrease in %R was observed for the AH domain during capacitation in vitro and incubation under control conditions, but no significant change in %R was observed in the AH domain during capacitation in vivo. A significant decline in %R of the PH domain was observed for spermatozoa during capacitation in vivo, in vitro and following incubation under non‐capacitating conditions. These data indicate that the changes in the lipid diffusibility of the AH and PH domains which occur during capacitation in vivo exhibit both similarities and differences to those which occur during capacitation in vitro. Mol. Reprod. Dev. 50:86–92, 1998. © 1998 Wiley‐Liss, Inc.
Venous thromboembolism after abdominal surgery in patient with recurrence of urinary bladder cancer — case report

Venous thromboembolism is a relevant complication in patients operated for oncological reasons. Authors discuss the problem of primary and secondary thromboprophylaxis in this group of patients on the basis of the case of woman with recurrence of urinary bladder carcinoma, in whom palliative, abdominal operation was performed.
Review of human bone remains from Smolensk necropolis (19th century, Tver, Russia): excavations of 2018

Human bone remains from 19th-century Smolensk necropolis (Tver, Russia) are analyzed. Age, sex, and height distribution is close to that of 18th-century necropolis of Tver. Although with caries, most of the buried show the sign of improved oral hygiene as their teeth lack calculus, characteristic for the Tver population of earlier times. Some pathologies and traumas are described.
UvA-DARE ( Digital Academic Repository ) Predictors of cognitive and psychosocial outcome after STN DBS in Parkinson ' s Disease

We aimed to clarify the profile of cognitive impairment in ALS, by meta-analysis of published studies. Criteria for inclusion were: ALS diagnosed according to El Escorial criteria; control group matched for age and education; correction for bias due to motor impairment or dysarthria; no dementia in patients and controls. Effect sizes reflecting a difference in neuropsychological performance between ALS patients and controls were calculated for 12 cognitive domains. The effect of demographic and clinical variables (age, disease duration, site of onset) on cognition was assessed in a moderator analysis. Of 48 eligible articles, 16 studies encompassing 554 ALS patients were included. Significant effect sizes were found for the Mini Mental State Examination (d 0.8), immediate verbal memory (d 0.5), visual memory (d 0.4), fluency (d 0.5), psychomotor speed (d 0.7), language (d 0.5) and executive functioning (d 0.3). The results of the latter three domains are less reliable due to the possibility of publication bias. Psychomotor speed, and to a lesser extent fluency, may have been influenced by motor impairment, despite attempts to correct for motor slowness. In conclusion, the diversity of cognitive problems in ALS seems greater than was previously thought. ALS patients may suffer from cognitive impairment in multiple domains, including memory dysfunction.
Performance Of Sharia Equity Funds And Conventional Equity Funds, Which One Is Better ?

Everant Journals/AFMJ Account and Financial Management Journal ISSN: 2456-3374 ; Volume 2 Issue 11 November 2017 ; Page no.1035-1045 ; Iim Hilman - STIE EKUITAS School of Business ; Jl. P.H. Hasan Mustopa No. 31 Bandung, Indonesia
Genomic Diversity and Relatedness of Bifidobacteria Isolated from a Porcine Cecum

ABSTRACT This study initially involved the isolation of a number of bifidobacteria from either the lumen or the epithelium of a porcine cecum. A total of 160 isolates were selected at random on MRS plates containing cysteine hydrochloride (0.5 g/liter) and mupirocin (50 mg/liter). All were identified as bifidobacteria based on fructose-6-phosphate phosphoketolase activity. Following genomic digestion with the restriction enzyme XbaI and pulsed-field gel electrophoresis (PFGE), the isolates produced 15 distinct macro-restriction patterns. Several of the PFGE patterns differed by only 1, 2, or 3 DNA fragments and were grouped as related patterns into seven PFGE types, termed A through G. The related patterns appeared to show genomic plasticity within the isolates arising from chromosomal mutations or possibly horizontal transfer of plasmids. The relative frequency of each PFGE type was maintained within each cecal sample, with PFGE type E representing approximately 50% of the isolates. Randomly amplified polymorphic DNA PCR, cell morphology, whole-cell protein profiling, 16S ribosomal DNA sequencing, and DNA-DNA hybridization were used to determine if the seven apparently unrelated PFGE types represented genetically distinct isolates. Four groups were identified: PFGE types A, C/D/G, B/E, and F, and these appeared to represent Bifidobacterium minimum, Bifidobacterium pseudolongum subsp. pseudolongum, and Bifidobacterium pseudolongum subsp. globosum and two new species, respectively. The data demonstrate the presence of considerable genomic diversity within a relatively simple bifidobacteria population, consisting of 15 distinct strains representing four groups, which was maintained throughout the porcine cecal contents and epithelial layer.
Chapter 19 Mixture Models in Astronomy

Mixture models combine multiple components into a single probability density function. They are a natural statistical model for many situations in astronomy, such as surveys containing multiple types of objects, cluster analysis in various data spaces, and complicated distribution functions. This chapter in the CRC Handbook of Mixture Analysis is concerned with astronomical applications of mixture models for cluster analysis, classification, and semi-parametric density estimation. We present several classification examples from the literature, including identification of a new class, analysis of contaminants, and overlapping populations. In most cases, mixtures of normal (Gaussian) distributions are used, but it is sometimes necessary to use different distribution functions derived from astrophysical experience. We also address the use of mixture models for the analysis of spatial distributions of objects, like galaxies in redshift surveys or young stars in star-forming regions. In the case of galaxy clustering, mixture models may not be the optimal choice for understanding the homogeneous and isotropic structure of voids and filaments. However, we show that mixture models, using astrophysical models for star clusters, may provide a natural solution to the problem of subdividing a young stellar population into subclusters. Finally, we explore how mixture models can be used for mathematically advanced modeling of data with heteroscedastic uncertainties or missing values, providing two example algorithms, the measurement error regression model of Kelly (2007) and the Extreme Deconvolution model of Bovy et al. (2011). The challenges presented by astronomical science, aided by the public availability of catalogs from major surveys and missions, are a rich area for collaboration between statisticians and astronomers. 1 ar X iv :1 71 1. 11 10 1v 2 [ as tr oph . I M ] 2 8 Ja n 20 19 2 Handbook of Mixture Analysis 19.
The Transmembrane Adaptor Cbp/PAG1 Controls the Malignant Potential of Human Non–Small Cell Lung Cancers That Have c-Src Upregulation

The tyrosine kinase c-Src is upregulated in various human cancers, although the precise regulatory mechanism underlying this upregulation is unclear. We previously reported that a transmembrane adaptor Csk-binding protein (Cbp; PAG1) plays an important role in controlling the cell transformation that is induced by the activation of c-Src. To elucidate the in vivo role of Cbp, we examined the function of Cbp in lung cancer cell lines and tissues. In this study, we found that Cbp was markedly downregulated in human non–small cell lung cancer (NSCLC) cells. The ectopic expression of Cbp suppressed the anchorage-independent growth of the NSCLC cell lines (A549 and Lu99) that had upregulated c-Src, whereas the Cbp expression had little effect on other NSCLC cell lines (PC9 and Lu65) that express normal levels of c-Src. The expression of Cbp suppressed the kinase activity of c-Src in A549 cells by recruiting c-Src and its negative regulator, C-terminal Src kinase (Csk), to lipid rafts. The treatment with Src inhibitors, such as PP2, dasatinib, and saracatinib, also suppressed the growth of A549 cells. Furthermore, Cbp expression attenuated the ability of A549 cells to form tumors in nude mice, invade in vitro, and metastasize in vivo. In addition, we found a significant inverse correlation between the level of Cbp expression and the extent of lymph node metastasis in human lung cancers. These results indicate that Cbp is required for the Csk-mediated inactivation of c-Src and may control the promotion of malignancy in NSCLC tumors that are characterized by c-Src upregulation. Mol Cancer Res; 9(1); 103–14 ©2010 AACR.
Quantum mechanics and modelling of physical reality .

Quantum mechanics led to spectacular technological developments, discovery of new constituents of matter and new materials: however there is still no consensus on its interpretation and limitations. Some scientists and scientific writers promote some exotic interpretations and evoke quantum magic. In this paper we point out that magical explanations mean the end of the science. Magical explanations are misleading and counterproductive. We explain how a simple probabilistic locally causal model is able to reproduce quantum correlations in Bell tests. We also discuss difficulties of mathematical modelling of the physical reality and dangers of incorrect mental images. We examine in detail when and how a probabilistic model may describe completely a random experiment. We give some arguments in favor of contextual statistical interpretation of quantum mechanics. We conclude that we still don’t know whether the quantum theory provides a complete description of physical phenomena and we explain how it may be tested. We also point out that there remain several open questions and challenges which we discuss in some detail. In particular there is still no consensus about how to reconcile quantum theory with general relativity and cosmology.
Randomized Non-inferiority Clinical Trial Evaluating Three Commercial Dry-Cow Mastitis Preparations

Based on Publications: Arruda AG, Godden S, Rapnicki P, et al. Randomized non-inferiority clinical trial evaluating three commercial dry-cow mastitis preparations: I. Quarter-level outcomes. J. Dairy Sci 2013;96(7):4419–4435. Arruda AG, Godden S, Rapnicki P, et al. Randomized non-inferiority clinical trial evaluating three commercial dry-cow mastitis preparations: II. Cow health and performance in early lactation. J Dairy Sci 2013;96(10):6390–6399.
Valuing of knowledge in organizations and its embedding into organizational practices and routines

Purpose – This study aims to analyze the impact of the different ways in which organizational members perceive and experience valuing of knowledge within the work context on its subsequent embedding into organizational routines. Design/methodology/approach – The phenomenographic method was applied, using in-depth semi-structured interviews for data collection. The intentional sample comprised twenty-two human resource professionals. Findings – The structural context, which the organization is part of, creates the social and spatial context that shapes a structuring pattern. This pattern establishes the way people consider knowledge of value and act to embed it into organizational practices and routines. Originality/value – The study reveals the relevance of contemporary organizational structures and forms – cooperatives, hybrid and social business; holacratic or entrepreneurial models; collaborative or partnership networks for innovation – that promote the use and embedding of individual knowledge into organizational routines and practices.
Actin cytoskeletal remodeling with protrusion formation is essential for heart regeneration in Hippo-deficient mice

Inhibiting the Hippo pathway could promote heart regeneration by encouraging heart cells to move into injured areas. Helping cardiomyocytes fill in a broken heart Activation of the Hippo pathway prevents the overgrowth of organs, such as the heart, by inhibiting the activity of the transcriptional coactivator Yap. This function of the Hippo pathway is important during development, but limits the ability of some organs to regenerate after injury. Morikawa et al. found that Yap target genes not only included cell cycle genes but also genes encoding cytoskeletal remodeling proteins or proteins that link the cytoskeleton to the extracellular matrix. Unlike cultured cardiomyocytes from control mice, those from Hippo signaling–deficient mice migrated through collagen, a key component of the extracellular matrix in the heart. Cardiomyocytes in these mice formed cellular protrusions typical of migrating cells and more readily moved toward scar sites after cardiac injury. Thus, inhibiting the Hippo pathway could help with heart regeneration. The mammalian heart regenerates poorly, and damage commonly leads to heart failure. Hippo signaling is an evolutionarily conserved kinase cascade that regulates organ size during development and prevents adult mammalian cardiomyocyte regeneration by inhibiting the transcriptional coactivator Yap, which also responds to mechanical signaling in cultured cells to promote cell proliferation. To identify Yap target genes that are activated during cardiomyocyte renewal and regeneration, we performed Yap chromatin immunoprecipitation sequencing (ChIP-Seq) and mRNA expression profiling in Hippo signaling–deficient mouse hearts. We found that Yap directly regulated genes encoding cell cycle progression proteins, as well as genes encoding proteins that promote F-actin polymerization and that link the actin cytoskeleton to the extracellular matrix. Included in the latter group were components of the dystrophin glycoprotein complex, a large molecular complex that, when defective, results in muscular dystrophy in humans. Cardiomyocytes near the scar tissue of injured Hippo signaling–deficient mouse hearts showed cellular protrusions suggestive of cytoskeletal remodeling. The hearts of mdx mutant mice, which lack functional dystrophin and are a model for muscular dystrophy, showed impaired regeneration and cytoskeleton remodeling, but normal cardiomyocyte proliferation, after injury. Our data showed that, in addition to genes encoding cell cycle progression proteins, Yap regulated genes that enhance cytoskeletal remodeling. Thus, blocking the Hippo pathway input to Yap may tip the balance so that Yap responds to mechanical changes associated with heart injury to promote repair.
A 24-chromosome FISH technique in preimplantation genetic diagnosis: validation of the method

Abstract Embryo screening for aneuploidy (AS) is part of preimplantation genetic diagnostics (PGD) and is aimed at improving the efficiency of assisted reproduction. Currently, several technologies, including the well-established fluorescence in situ hybridization (FISH) technique, cover the screening of all chromosomes in a single cell. This study evaluates a novel 24-chromosome FISH technique protocol (FISH-24). A total of 337 embryos were analyzed using the traditional 9-chromosome FISH technique (FISH-9) while 251 embryos were evaluated using the new FISH-24 technique. Embryos deemed nontransferable on Day 3 were cultured in vitro to Day 5 of development, then fixed and reanalyzed according to the technique allocated to each treatment cycle (107 embryos analyzed by FISH-9 and 111 by FISH-24). The global error rate (discrepancy between Day 3 and Day 5 results for a single embryo) was 2.8% after FISH-9 and 3.6% after FISH-24, with a p value of 0.95. Thus, we have established and validated a 24-chromosome FISH-based single cell aneuploidy screening technique, showing that the error rate obtained for FISH-24 is independent of the number of chromosomes analyzed and equivalent to the error rate observed for FISH-9, as a useful tool for chromosome segregation studies and clinical use.
Numerical models of the Eregion ionosphere

Although the ambient E-region of the ionosphere has been fairly well characterized in the non-auroral regions with respect to density, ion composition, and variability, it is not as well understood as might be expected from a theoretical point of view. This is due primarily to uncertainties in the solar irradiance that produces E-region ionization (mainly the H Lyman-b line and the soft X-ray region), and to the variability of odd-nitrogen species that control ion composition. Recent measurements from the SNOE, TIMED, and SORCE satellites have greatly improved our quantitative understanding of both solar spectral irradiance and lower thermosphere nitric oxide, which in turn improves our ability to accurately model the E-region. The new measurements indicate higher solar soft X-ray irradiance but lower flux in the H Lyman-b line than earlier estimates by Hinteregger et al. [Hinteregger, H.E. , Fukui, K. , Gilson, B.R. , Observational, reference, and model data on soalr EUV, from measurements on AE–E. Geophys. Res. Lett. 8 (1981) 1147] based on measurements from Atmosphere Explorer and from rocket flights. However, preliminary results from the Solar EUV Experiment (SEE) on the TIMED satellite are in better agreement with the EUVAC model [Richards, P.G. , Fenenelly, J.A. , Torr, D.G. , EUVAC: a solar EUV flux model for aeronomic calculations. J. Geophys. Res. 99 (1994) 8981–8992]. This raises the question of whether either of these representations of the solar spectrum can adequately represent E-region electron density and variation. Model simulations of the E-region using these two solar model inputs are compared to the International Reference Ionosphere (IRI) empirical model, which has been validated using measurements from the Boulder ionosonde. Calculations using the Hinteregger et al. solar inputs significantly underestimate the peak electron densities at all levels of activity, while using EUVAC solar inputs produces better agreement but slightly more variability than the empirical representations. As improved estimates of variability from TIMED/SEE over a complete solar cycle become available, these remaining discrepancies may be resolved. 2005 COSPAR. Published by Elsevier Ltd. All rights reserved.