Miracle-dz/UniFAR-FTUs huggingface dataset:
Climate change and the future occurrence of moorland wildfires in the Peak District of the UK

We investigated the impact of climate change on the number of wildfires in the Peak District uplands of northern England. Wildfires in peat can result in severe carbon loss and damage to water supplies, and fighting such fires is difficult and costly in such a remote location. The Peak District is expected to experience warmer, wetter winters and hotter, drier summers. Local weather simulations from a weather generator were used to predict the future incidence and timing of fires. Wildfire predictions were based on past fire occurrence and weather over 27.5 yr. A Probit model of wildfire incidence was applied to simulated weather data, which were generated by a Markov pro- cess and validated against actual baseline weather data using statistical criteria and success in repli- cating past fire patterns. The impact of climate change on the phenology and ecology of moorland and on visitor numbers was considered. Simulations suggest an overall increase in occurrence of summer wildfires. The likelihood of spring wildfires is not reduced by wetter winter conditions; how- ever, the chance of wildfires rises as rainfall decreases. Temperature rise has a non-linear impact, with the risk of wildfire occurrence rising disproportionately with temperature. Recreation use is a major source of ignition. Little change in wildfire incidence is projected in the near future, but as cli- mate change intensifies, the danger of summer wildfires is projected to increase from 2070; therefore, fire risk management will be necessary in future. In addition, moorlands may have to be managed to reduce the chance of summer wildfires becoming catastrophic, with consequent damage to eco- system services such as water supplies and peat carbon storage. Management measures may include controlled burning, grazing or mowing to remove fuel.
Inactivation of a Helicobacter pylori DNA methyltransferase alters dnaK operon expression following host-cell adherence.

The Helicobacter pylori hpyIM gene encodes a type II DNA methyltransferase that is highly conserved among strains. To investigate the potential role of M.HpyI methyltransferase activity in controlling gene expression in H. pylori, we analyzed gene transcription profiles in wild-type strain J166 and an isogenic hpyIM mutant strain using gene arrays. This analysis showed that the expression of a majority of genes was unaffected by hpyIM mutation, especially in exponential phase cultures. However, in stationary phase cultures and in cells adherent to AGS gastric epithelial cells in vitro, loss of hpyIM function altered the expression of the stress-responsive dnaK operon. Complementation of the hpyIM mutation using a shuttle plasmid encoding a wild-type copy of the gene re-established the wild-type pattern of dnaK operon expression. These data suggested that hpyIM, encoding a DNA methyltransferase, may have a role in H. pylori physiology that supersedes its original function in a type II restriction-modification system.
Inhibiting factors to tax revenue generation in Cross River State, Nigeria

This study examined the inhibiting factors to tax revenue generation in Cross River State, Nigeria. The specific objectives were to examine the effect of tax evasion and avoidance, lack of infrastructural facilities and experienced personnel on tax revenue generation in Cross River State. To achieve these objectives, a well structure questionnaire was development and administered on 169 sampled staff of Cross River State board of internal revenue. Out of these questionnaires 164 were duly completed and returned. These responses were coded and used for analyses with the help of the SPSS software The cross sectional survey design was adopted and the ordinary least squared multiple regression technique was used to analyze the data. From the analyses it was discovered that there is a negative correlation and insignificant relationship between lack of infrastructural facilities and government tax revenue in Cross River State; also, there is a negative and significant relationship between tax evasion and avoidance and government tax revenue in Cross River State, Nigeria and lastly, there is a positive and significant relationship between experienced personnel and government tax revenue in Cross River State, Nigeria. Based on these finding the study recommends that government should encourage tax payers’ morale through the provision of quality infrastructural facilities and other incentives to enhance its revenue generation. Also, Strategies to reduce tax evasion and avoidance should be formulated by strengthening the policy framework and operational guidelines of the Cross River State internal revenue service and adopting an evidence base government spending. Lastly, Cross River State internal revenue service should embark on adequate staff training and development on new methods of enhancing tax compliance within the state. Keywords: Tax Revenue Compliance, Tax Evasion and Avoidance
A hybrid model of system dynamics and genetic algorithm to increase crude palm oil production in Malaysia

Palm oil industry in Malaysia is facing a stagnant growth in terms of crude palm oil (CPO) production as compared to Indonesia due to three issues namely (i) the scarcity of plantation area, (ii) labour shortage, and (iii) the rising demand from palm-based biodiesel industry. Focusing on these issues, previous studies have been adopted various approaches. However, these non-hybridized methods have some shortcomings and can be improved by hybridization method. Hence, the objective of this research is to determine the optimal policy options to increase CPO production in Malaysia. In this research, a hybrid model of system dynamics (SD) and genetic algorithm (GA) was developed to determine the optimal policy in increasing the CPO production in Malaysia. Five policy variables namely mechanization adoption rate, average replanting, biodiesel mandates in transportation, industrial and 4 other relevant sectors were examined to determine optimal policy values. These five policy variables were tested in three scenarios: year 2017, year 2020, and in phases until 2050. From all the scenarios, the phase optimization emerged as the most effective in producing suitable policy variable values in order to obtain the best possible value of CPO production in year 2050 up to 20 GA population runs. The hybrid of SD-GA through phase optimization process is capable to recommend policies that are plausible to be implemented to avoid unwarranted shock to the industry. Furthermore, the hybrid model provides the ability of identifying the policy variables related to the objective function at any specific time line. From the managerial perspectives, this research helps the stakeholders in palm oil industry towards making a better future investment decision.
Reassessment: vagus nerve stimulation for epilepsy.

To the Editor: I write to Neurology and the American Academy of Neurology (AAN) not regarding the content of the special article entitled “Reassessment: vagus nerve stimulation for epilepsy,”1 but regarding the principles underlying critical reviews. Given the scientific background of our profession, I would assume that a subcommittee titled “Therapeutics and Technology Assessment” would have a mandate to critique objectively. Can Drs. Fisher and Handforth1 be objective? “Disclosure: Both authors have received speaker’s bureau support from Cyberonics … Dr. Handforth has received research support from Cyberonics and also served as the lead author in the E05 study of VNS … . ”1 It is unrealistic that some degree of bias, perhaps even considerable bias, will not color their words. Why did the AAN choose …
A Sorrow Halved? A Daily Diary Study on Talking About Experienced Workplace Incivility and Next-Morning Negative Affect

Incivility by coworkers and customers can have detrimental consequences for employees’ affective well-being at work. However, little is known about whether incivility also impairs employees’ affect at home and how long these negative effects may last. In this diary study, we examine whether incivility by coworkers and customers is related to next-morning negative affect via negative affect at the end of the workday and at bedtime, and investigate different modes of social sharing (i.e., conversations about experienced mistreatment) as day-level moderators of this relationship. Daily diary data collected over 10 workdays (N = 113 employees) revealed that coworker incivility was indirectly related to bedtime negative affect via negative affect at the end of the workday, and customer incivility was indirectly related to next-morning negative affect via negative affect at the end of the workday and at bedtime. Although we found no moderating effect for conversations in an affective sharing mode (i.e., conversation partners provide comfort and consolation), the relationship between workplace incivility and employees’ negative affect was buffered by conversations in a cognitive sharing mode (i.e., conversation partners suggest alternative explanations or reappraisal of uncivil behavior). In line with social sharing theory, our results suggest that talking about experienced mistreatment can, under specific circumstances, offset the negative relationship of uncivil coworker and customer behavior and employees’ negative affect. This study advances current research on workplace incivility by studying negative affect 3 times a day and thus sheds light on the mechanism connecting workplace incivility and employees’ affective well-being at home.
Patient‐reported quality of life, unmet needs and care coordination outcomes: Moving toward targeted breast cancer survivorship care planning

Survivorship care plans (SCPs) have been proposed for universal use with the aim of addressing the many unmet needs of cancer survivors. Trials have failed to find a significant impact of SCPs on quality of life outcomes. This study evaluated quality of life, unmet needs, satisfaction with health care and perception of cancer care coordination at the end of treatment in a cohort of women at the end of treatment for early breast cancer. The aim was to identify specific needs to assist in the design of a tailored SCP.
Labour productivity motivation framework for Iskandar Malaysia

Purpose The purpose of this paper is to develop a motivation framework that will enhance labour productivity for Iskandar Malaysia (IM) construction projects. The vision of IM development corridor is to become Southern Peninsular Malaysia’s most developed region by the year 2025. IM cannot realise this foresight without effective labour productivity. Previous studies have reported that the labour productivity of IM construction projects was six times lower than the labour productivity of Singapore construction projects, due to lack of motivation among IM labourers, and a shortage of local skilled labour. Therefore, there is a need to study how to motivate IM construction labourers, so as to increase their productivity. Design/methodology/approach A quantitative research method was used to collect data from IM construction skilled labourers and construction professionals, using two sets of questionnaire. The respondents were selected using a purposive sampling technique. In total, 40 skilled labourers and 50 construction professionals responded to the questionnaire survey, and the data were analysed using Statistical Package for Social Science software (version 22). Findings The analysis revealed the major factors that motivate labourers participating in IM construction projects. The factors were ranked hierarchically using Relative Importance Index (RII) and the outcome of the ranking indicated that effective management, viable construction practices, financial incentives, continuous training and development, and safe working environment were the most significant motivation strategies that positively influence IM construction labourers. Originality/value The study developed and validated a framework that can be used to boost the morale of IM construction labourers, so that their productivity can be increased. Implementation of the established motivation framework will also lead to career progression of IM construction labourers, based on the training elements in the framework. This career prospect will attract local skilled labourers to participate in IM construction projects.
Generation of Uniform-Hazard Earthquake Ground Motions

This paper presents statistical models for the generation of biaxial earthquake ground-motion time histories with spectra that match those from samples of ground-motion records. The model parameters define near-field characteristics such as pulse velocity and pulse period, far-fault characteristics such as velocity amplitude and power spectral density, and envelope characteristics. The samples of ground motions used in this study were previously selected and scaled to be representative of particular hazard levels in particular geographical regions. A companion paper presents the fitting of the model to samples of ground-motion waveforms. In this paper, the new concept of a parameter-response correlation spectrum establishes the period-dependence of the correlation between the response spectrum and ground-motion parameters. Parameters that correlate to variability of the response spectra are retained as random variables and then fit to mean and mean-plus-standard deviation of biaxial response spectra of th.
Meretas Kinerja Maqashid Syariah Pada Bank Umum Syariah Indonesia

Tujuan dari penelitian ini ialah untuk menganalisis kinerja Bank Syariah Indonesia berdasarkan Maqashid Syariah. Penelitian ini menggunakan metode deskriptif. Objek penelitian ini adalah Bank Umum Syariah Indonesia dengan jumlah sampel yaitu 9 Bank. Data yang digunakan dalam penelitian ini berupa anuual report tahun 2015-2017. Hasil penelitian menunjukkan bahwa kinerja maqashid syariah pada BUS di Indonesia masih berfluktuatifhal ini dapat dilihat dari kinerja maqashid syariah selama tahun 2015-2017 berturut-turut sebesar 24,07%, 25,50% dan 24,73%. Kinerja maqashid syariah yang berfluktuasi disebabkan belum adanya kesadaran para stakeholder untuk memperhatikan kinerja maqashid syariah. Dari 3 tujuan maqashid syariah yaitu; mendidik individu, membangun keadilan dan kepentingan publik, prosentase tertinggi adalah tujuan membangun keadilan. Bank Syariah Mandiri memiliki kinerja maqashid syariah paling tinggi dibanding Bank Umum Syariah lainnya.
Switch in 3′ Splice Site Recognition between Exon Definition and Splicing Catalysis Is Important for Sex-lethalAutoregulation

ABSTRACT Maintenance of female sexual identity in Drosophila melanogaster involves an autoregulatory loop in which the protein Sex-lethal (SXL) promotes skipping of exon 3 from its own pre-mRNA. We have used transient transfection of Drosophila Schneider cells to analyze the role of exon 3 splice sites in regulation. Our results indicate that exon 3 repression requires competition between the 5′ splice sites of exons 2 and 3 but is independent of their relative strength. Two 3′ splice site AG's precede exon 3. We report here that, while the distal site plays a critical role in defining the exon, the proximal site is preferentially used for the actual splicing reaction, arguing for a switch in 3′ splice site recognition between exon definition and splicing catalysis. Remarkably, the presence of the two 3′ splice sites is important for the efficient regulation by SXL, suggesting that SXL interferes with molecular events occurring between initial splice site communication across the exon and the splice site pairing that leads to intron removal.
Improved Prediction of Drug‐Induced Torsades de Pointes Through Simulations of Dynamics and Machine Learning Algorithms

The ventricular arrhythmia Torsades de Pointes (TdP) is a common form of drug‐induced cardiotoxicity, but prediction of this arrhythmia remains an unresolved issue in drug development. Current assays to evaluate arrhythmia risk are limited by poor specificity and a lack of mechanistic insight. We addressed this important unresolved issue through a novel computational approach that combined simulations of drug effects on dynamics with statistical analysis and machine‐learning. Drugs that blocked multiple ion channels were simulated in ventricular myocyte models, and metrics computed from the action potential and intracellular (Ca2+) waveform were used to construct classifiers that distinguished between arrhythmogenic and nonarrhythmogenic drugs. We found that: (1) these classifiers provide superior risk prediction; (2) drug‐induced changes to both the action potential and intracellular (Ca2+) influence risk; and (3) cardiac ion channels not typically assessed may significantly affect risk. Our algorithm demonstrates the value of systematic simulations in predicting pharmacological toxicity.
Antecedents of consumers’ engagement with brand-related content on social media

Purpose The purpose of this paper is to investigate the effect of brand’s social media marketing efforts and individual’s online social interaction propensity on various levels of consumers’ engagement with brand-related social media content. Additionally, the subsequent effects of consumers’ engagement with brand-related social media content on overall brand equity and purchase intention have also been examined. Design/methodology/approach Preliminary studies were conducted to identify brands for the main study. Data for the main study were collected using an online survey administered at the identified brands’ Facebook fan pages. Structural equation modeling was used to test the conceptual model. Findings The results found the uniform effect of the social media marketing efforts and individual’s online social interaction propensity on two levels of consumers’ social media engagement, but the effect on third level has been found only from the individual’s online social interaction propensity. Subsequent effects on brand equity and purchase intention were also found varying across the engagement levels. Research limitations/implications This study extends previous research by examining the effect of brand’s social media marketing efforts and online social interaction propensity on all the three levels of consumers’ engagement with brand-related content on social media. Also, this study enriches the existing literature by investigating the impact of these three levels of consumers’ engagement on brand’s equity and purchase intention. Originality/value Previous research has no evidence of evaluating the effectiveness of social media marketing efforts on the consumers’ engagement with brand-related social media content. Although the effect of general online social interaction propensity on effort and social engagement has been examined in previous research but the effect on consumption, contribution and creation brand-related social media content had not been measured. Additionally, the effect of consumption, contribution and creation on brand equity and purchase intention had not been evaluated.
Examination of bioluminescent excitation responses using empirical orthogonal function analysis

Bioluminescent intensities were measured August 30th-September 4th, 2004 in the Gulf of Maine with the HIDEX III Bathyphotometer. Empirical orthogonal function (EOF) analysis and complex empirical orthogonal function (CEOF) analysis were applied to these data sets in order to determine a unique excitation response for each species of bioluminescent organism encountered in the data sets. Using the results of the analysis, a filter was designed for real-time identification of dinoflagellates.
Vasculitis in rheumatoid arthritis

Purpose of reviewTo examine the occurrence and pathophysiology of vasculitis in rheumatoid arthritis (RA), describe the epidemiology and clinical features, and provide a therapeutic perspective. Recent findingsWith improved control of RA over the past two decades, the risk of severe outcomes such as vasculitis may be decreasing. Rheumatoid vasculitis continues to be associated with longstanding, erosive, seropositive disease, and it has recently been shown to be more frequent among patients with antibodies to cyclic citrullinated peptides. Apart from circulating immune complexes, expansion of cytotoxic CD28null T cells and circulating proinflammatory cytokines also play a role in the pathogenesis. The role of agents directed against the tumor necrosis factor (TNF) in the occurrence and management of rheumatoid vasculitis remains unclear, as rheumatoid vasculitis may be both associated with and treated with anti-TNF agents, once it has appeared. SummaryVasculitis in RA is generally associated with longstanding disease, has an important impact on a patient's well being, and markedly influences patient life expectancy. Advances in therapies for RA will likely continue to reduce the incidence of vasculitis, and improved management of cardiovascular comorbidity in patients with RA will be of particular benefit to those who suffer from vasculitis and other extraarticular manifestations.
Personality and Social Psychology Be yourself, believe in yourself, and be happy: Self-efficacy as a mediator between personality factors and subjective well-being

Research has shown close connections between personality and subjective well-being (SWB), suggesting that personality traits predispose individuals to experience different levels of SWB. Moreover, numerous studies have shown that self-efficacy is related to both personality factors and SWB. Extending previous research, we show that general self-efficacy functionally connects personality factors and two components of SWB (life satisfaction and subjective happiness). Our results demonstrate the mediating role of self-efficacy in linking personality factors and SWB. Consistent with our expectations, the influence of neuroticism, extraversion, openness, and conscientiousness on life satisfaction was mediated by self-efficacy. Furthermore, self-efficacy mediated the influence of openness and conscientiousness, but not that of neuroticism and extraversion, on subjective happiness. Results highlight the importance of cognitive beliefs in functionally linking personality traits and SWB.