Miracle-dz/UniFAR-FTUs huggingface dataset:
Tapered Titanium Cementless Total Hip Replacements: A 10-to 13-Year Followup Study

The 10-to-13 year performance of 307 Mallory Head cementless tapered total hip replacements in 283 patients was assessed. Eighty-five percent of patients had a diagnosis of osteoarthritis. Fifty-one percent of patients were women. The mean patient age was 64 ± 10 years. The Hex Loc cementless acetabular component and titanium alloy femoral heads were used in each patient. At final followup, 37 (13%) patients died, 32 (10%) had revision surgery, and two (1%) were lost to followup. No femoral stem was revised for aseptic loosening, but one was revised because of sepsis and one was revised because of a periprosthetic fracture. Wear, osteolysis, and loosening were problems with the Hex Loc cementless acetabular components and 31 (10%) acetabular components required revision because of these mechanisms. The mean Harris hip score at final followup of the remaining patients was 87 ± 14 points. Three percent of these patients had thigh pain. Radiographic assessment revealed that no femoral stem or acetabular socket was definitely or probably loose. Three-dimensional wear assessment using the Devane technique was 0.35 mm per year. The Mallory Head cementless, tapered femoral component performed well in the patients in the current study, but unfortunately, the clinical results were compromised by the use of a suboptimal cementless acetabular component, the use of polyethylene that was gamma-irradiated in air, and by the use of titanium alloy femoral heads. Future developments obviously will be in the areas of better acetabular component design, alternate polyethylene sterilization methods, and enhancements of the femoral stem in terms of offset choices, neck design, and perhaps ingrowth surface.
Retracted Publications Within Radiology Journals.

OBJECTIVE The purpose of this study was to characterize trends related to retracted publications within radiology journals. MATERIALS AND METHODS PubMed was queried to identify all articles with the publication type "retracted publication" or "notification of retraction. " Articles published within radiology journals were identified using Journal Citation Reports' journal categories. Available versions of original articles and publication notices were accessed from journal websites. Citations to retracted publications were identified using Web of Science. Overall trends were assessed. RESULTS Forty-eight retracted original research articles were identified within radiology journals since 1983, which included 1.1% of all PubMed "retracted publication" entries. Distinct PubMed entries were available for the retracted publication and retraction notification in 39 of 48 articles. The original PDF was available for 37 articles, although the articles were not watermarked as retracted in 23 cases. In six cases with a watermarked PDF, further searches identified nonwatermarked versions. Original HTML versions were available for 13 articles but 11 were not watermarked. The mean (± SD) delay between publication and retraction was 2.7 ± 2.8 years (range, 0-16 years). The mean number of citations to retracted articles was 10.9 ± 17.1 (range, 0-94 citations). Reasons for retraction included problematic or incorrect methods or results (although it typically was unclear whether these represented honest errors or misconduct) in 33.3% of cases, complete or partial duplicate publication in 33.3% of cases, plagiarism in 14.6% of cases, a permission issue in 8.3% of cases, the publisher's error in 6.3% of cases, and no identified reason in 6.3% of cases. One or no retractions occurred annually from 1986 to 2001, although two or more retractions occurred annually in nine of the 12 years from 2002 through 2013. CONCLUSION Retraction represents an uncommon, yet potentially increasing, issue within radiology journals that publishers have inconsistently and insufficiently addressed. Greater awareness and training in proper biomedical research conduct, as well as establishment and enforcement of standardized publishers' policies, are warranted.
Implantation of the rat egg. II. Alteration in osmiophilic epithelial lipids of the rat uterus under normal and experimental conditions

While a full understanding of events occurring during the implantation period of the mammalian embryo seems, in spite of an impressive body of literature, still to be a long way off, thc problem of the interaction of maternal and embryonic elements is being investigated with increasing vigor and interest and with growing success. Whereas the aims and interests of the various studies differ to a marked degree, an underlying common denominator is discernible and is invariably associated with the transitional period when the segmenting ovum has progressed maximally as a free entity and now requires intimate association with the maternal organism for further development. That the problems and the pertinent physiological processes of this period are identical in all species would be an unwarranted assumption ; yet, it is equally unlikely that differences are fundamental in character or of great magnitude. In any event, investigation of all species possible is surely desirable. It is the purpose of this paper to report the results of an investigation of the changes in osmiophilic epithelial fats in the rat uterus during the estrous and pregnancy cycles and under certain experimental conditions. For previous reports
Neural Mechanisms of Cardioprotection

This review highlights the importance of neural mechanisms capable of protecting the heart against lethal ischemia/reperfusion injury. Increased parasympathetic (vagal) activity limits myocardial infarction, and recent data suggest that activation of autonomic reflex pathways contributes to powerful innate mechanisms of cardioprotection underlying the remote ischemic conditioning phenomena.
Fragmented Inositol 1,4,5-Trisphosphate Receptors Retain Tetrameric Architecture and Form Functional Ca2+ Release Channels*

Background: Proteolytic cleavage and disruption of inositol 1,4,5-trisphosphate receptor (IP3R) architecture may contribute to the initiation/progression of apoptosis. Results: Proteolytic cleavage products of the IP3R remain membrane-associated, and these fragments form functional tetrameric channels. Conclusion: Fragmentation of the IP3R does not inevitably lead to loss of function. Significance: Peptide continuity is not required for IP3R function, and IP3R activation may persist after protease cleavage during apoptosis. Inositol 1,4,5-trisphosphate receptor isoforms are a family of ubiquitously expressed ligand-gated channels encoded by three individual genes. The proteins are localized to membranes of intracellular Ca2+ stores and play pivotal roles in Ca2+ homeostasis. Previous studies have demonstrated that IP3R1 is cleaved by the intracellular proteases calpain and caspase both in vivo and in vitro. However, the resultant cleavage products are poorly defined, and the functional consequences of these proteolytic events are not fully understood. We demonstrate that IP3R1 is cleaved during staurosporine-induced apoptosis, yielding N-terminal fragments encompassing the ligand-binding domain and the majority of the central modulatory domain together with a C-terminal fragment containing the channel domain and cytosolic tail. Notably, these fragments remain associated with the membrane after initiation of apoptotic cleavage. Furthermore, when recombinant IP3R1 fragments, corresponding to those predicted to be generated by caspase or calpain cleavage, are stably coexpressed in cells, they physically associate and form functional channels. These data provide novel insights regarding the regulation of IP3R1 during proteolysis and provide direct evidence that polypeptide continuity is not required for IP3R activation and Ca2+ release.
Roman domination in some special classes of graphs

A Roman dominating function of a graph G = (V, E) is a function f : V → {0, 1, 2} such that every vertex x with f(x) = 0 is adjacent to at least one vertex y with f(y) = 2. The weight of a Roman dominating function is defined to be f(V ) = P x∈V f(x), and the minimum weight of a Roman dominating function on a graph G is called the Roman domination number of G. In this paper we answer an open problem mentioned in [3] by showing that the Roman domination number of an interval graph can be computed in linear time. We also show that the Roman domination number of a cograph can be computed in linear time. Besides, we show that there are polynomial time algorithms for computing the Roman domination numbers of AT-free graphs and graphs with a d-octopus.
Predictive Risk Factors for Persistent Postherniotomy Pain

Background:Persistent postherniotomy pain (PPP) affects everyday activities in 5–10% of patients. Identification of predisposing factors may help to identify the risk groups and guide anesthetic or surgical procedures in reducing risk for PPP. Methods:A prospective study was conducted in 464 patients undergoing open or laparoscopic transabdominal preperitoneal elective groin hernia repair. Primary outcome was identification of risk factors for substantial pain-related functional impairment at 6 months postoperatively assessed by the validated Activity Assessment Scale (AAS). Data on potential risk factors for PPP were collected preoperatively (pain from the groin hernia, preoperative AAS score, pain from other body regions, and psychometric assessment). Pain scores were collected on days 7 and 30 postoperatively. Sensory functions including pain response to tonic heat stimulation were assessed by quantitative sensory testing preoperatively and 6 months postoperatively to assess nerve damage. Results:Four hundred sixty-four patients were included, whereof 442 were examined at 6 months (95.3% follow-up). Fifty-five patients (12.4%) had “moderate/severe” PPP at 6 months. Logistic regression analysis identified four risk factors for PPP: preoperative AAS score, preoperative pain to tonic heat stimulation, 30-day postoperative pain intensity, and sensory dysfunction in the groin at 6 months (nerve damage) (all P < 0.03). A risk prediction model of only preoperative factors and choice of surgical technique revealed increased preoperative AAS score, increased preoperative pain to heat stimulation, and open surgery to increase the risk for PPP (all P < 0.02). Conclusion:PPP is related to both patient and surgical factors. Patients with a high preoperative AAS score and high pain response to a standardized heat stimulus may preferably be treated using an operative technique with lowest risk for nerve damage.
Comprehensive allelotyping of human intrahepatic cholangiocarcinoma.

We performed a genome-wide scan for loss of heterozygosity (LOH) in 22 intrahepatic cholangiocarcinoma (ICC) cases using 168 polymorphic microsatellite markers throughout all of the human chromosomes and 48 markers of which LOH is reportedly characteristic of hepatocellular carcinoma (HCC). Markers with LOH in more than 30% of informative cases were observed at 21 loci. Among these, eight markers on 6q (three loci), 4q (two loci), 9q, 16q, and 17p shared high frequencies of LOH with HCC in our previous study. As for gross appearance, mass-forming type tumors showed higher frequency of LOH (P < 0.001) compared with other types. Compared by tumor size (< or =5 cm versus >5 cm), number (multiple versus solitary), and the International Union Against Cancer TNM classification (stage IVB versus II-IVA), LOH was observed more frequently in advanced stages (P < 0.01, respectively). However, LOH frequency does not differ regardless of lymph node status (pN0 versus pN1). Frequent LOH on 1p36 including the p73 locus was noted in large tumors without lymph node metastasis. These suggest that ICC shares some common carcinogenic steps with HCC such as LOH of 4q and 6q and that inactivation of tumor suppressor genes on chromosome 1p36 contributes to progression of ICC but not to metastatic traits.
Learning style, judgements of learning, and learning of verbal and visual information

The concept of learning style is immensely popular despite the lack of evidence showing that learning style influences performance. This study tested the hypothesis that the popularity of learning style is maintained because it is associated with subjective aspects of learning, such as judgements of learning (JOLs). Preference for verbal and visual information was assessed using the revised Verbalizer-Visualizer Questionnaire (VVQ). Then, participants studied a list of word pairs and a list of picture pairs, making JOLs (immediate, delayed, and global) while studying each list. Learning was tested by cued recall. The results showed that higher VVQ verbalizer scores were associated with higher immediate JOLs for words, and higher VVQ visualizer scores were associated with higher immediate JOLs for pictures. There was no association between VVQ scores and recall or JOL accuracy. As predicted, learning style was associated with subjective aspects of learning but not objective aspects of learning.
Molecular Evolution of Metallo-β-Lactamase-Producing Pseudomonas aeruginosa in a Nosocomial Setting of High-Level Endemicity

ABSTRACT An outbreak of multidrug-resistant Pseudomonas aeruginosa strains producing VIM-type metallo-β-lactamases (MBLs) has occurred in an Italian hospital since 2000 (C. Lagatolla, E. A. Tonin, C. Monti-Bragadin, L. Dolzani, F. Gombac, C. Bearzi, E. Edalucci, F. Gionechetti, and G. M. Rossolini, Emerg. Infect. Dis. 10:535-538, 2004). In this work, using molecular methods, we characterized 128 carbapenem-resistant isolates (including 98 VIM-positive isolates) collected from that hospital from 2000 to 2002 to investigate the dynamics of the dissemination of MBL producers in the clinical setting. Genotyping by random amplification of polymorphic DNA and pulsed-field gel electrophoresis showed that most VIM-positive isolates belonged to two different clonal lineages, producing either a VIM-1- or a VIM-2-like MBL, whose ancestors were detected for the first time in the hospital in 1999, suggesting that clonal expansion played a predominant role in the dissemination of these isolates. The 86 clonally related isolates carrying a blaVIM-1-like gene on an In70-like integron were clearly related to a VIM-1-positive P. aeruginosa clone circulating in various Italian hospitals since the late 1990s. VIM-negative P. aeruginosa strains related to the VIM-1-positive clone were detected during the same period, suggesting that the latter strain was derived from a clonal lineage already circulating in the hospital. In the VIM-2-like positive clone, the MBL gene was carried by an unusual class 1 integron, named In71, lacking the 3′ conserved sequence region typical of sul1-associated integrons. A different class 1 integron with an original structure carrying a blaVIM-2 determinant, named In74, was detected in a sporadic isolate. A retrospective investigation did not reveal the presence of strains related to any of the VIM-producing isolates earlier than 1997.
What worries parents when their preschool children are acutely ill, and why: a qualitative study

Abstract Objective: To identify and explore parents' concerns when young children become acutely ill. Design: Qualitative study making use of semi-structured one to one and group interviews with parents of preschool children. Setting: Disadvantaged inner city community. Subjects: 95 parents of preschool children. Results: Fever, cough, and the possibility of meningitis were parents' primary concerns when their children became acutely ill. Parents' concerns reflected lay beliefs, their interpretation of medical knowledge, and their fears that their child might die or be permanently harmed. Parents worried about failing to recognise a serious problem. Concerns were expressed within the context of keenly felt pressure, emphasising parents' responsibility to protect their child from harm. They were grounded in two linked factors: parents' sense of personal control when faced with illness in their child and the perceived threat posed by an illness. Conclusions: Better understanding of parents' concerns may promote effective communication between health professionals and parents. Modification of parents' personal control and perceived threat using appropriate information and education that acknowledge and address their concerns may be a means of empowering parents. Key messages Parents worried about fever, cough, the possi- bility of meningitis, and failing to recognise a seri- ous problem Better understanding of parents' concerns and what causes them may promote more effective communication between health professionals and parents
A spatio-temporal atlas of neonatal diffusion MRI based on kernel ridge regression

Spatio-temporal atlas is a useful tool in imaging studies of neurodevelopment, which characterizes the growth of brain, and allows the monitoring of its development. The imaging of preterm and term born infants provides opportunities to develop a series of spatio-temporal atlases that track the changes during the particular period of neurodevelopment between. The aim of this paper is to develop a spatio-temporal atlas of diffusion MRI for neonatal brains between 32 to 42 weeks postmenstrual age (PMA). We subdivided the cohort consisting of preterm- and term-born infants according to their PMA at the MRI scan based on a kernel ridge regression, and generated the atlases based on Fibre Orientation Distribution (FOD) reconstruction of the diffusion data.
Verification of the Change Blindness Phenomenon While Managing Critical Events on a Combat Information Display

Change blindness occurs when humans are unable to detect significant changes in objects and scenes after their attention is momentarily diverted. Because change blindness is relevant in many applied settings, the current study investigated the phenomenon in the context of tasks performed by naval command and control system personnel. Operators of such systems are often heavily loaded with concurrent visual search, situation assessment, voice communications, and controldisplay maninpulation tasks at large, physically dispersed tactical situation displays. As the operators' attention shifts from one display to another, it creates an opportunity for changes to occur on unattended screens with potentially negative consequences. Our results show that on a display containing 8 objects of interest, considerable change blindness was demonstrated in that participants required 2 or more selections to correctly identify a changed object on nearly 1/3 of the test trials. Further, operator performance on 15% of the trials was equivalent to randomly guessing with replacement after making 3 incorrect selections. This research underscores the need for developing effective countermeasures to the change blindness phenomenon. Actual or potential uses of this research include interface design of computer workstations for military, nuclear power industry, air traffic control, crisis response center, and hospital emergency room applications.
Control of glycolysis in contracting skeletal muscle

Crowther, Gregory J., Michael F. Carey, William F. Kemper, and Kevin E. Conley. Control of glycolysis in contracting skeletal muscle. I. Turning it on. Am J Physiol Endocrinol Metab 282: E67–E73, 2002. —Why does the onset of glycolytic flux in muscle lag the start of exercise? We tested the hypothesis that both elevated metabolite levels and muscle activity are required for flux to begin. Glycolytic flux was determined from changes in muscle pH, phosphocreatine concentration, and Pi concentration ([Pi]) as measured by 31P magnetic resonance spectroscopy. Eight subjects performed rapid ankle dorsiflexions to ;45% of maximal voluntary contraction force under ischemia at a rate of 1 contraction/s. Subjects completed two bouts of exercise separated by 1 min of ischemic rest. Glycolytic flux was activated by 27 s in the first bout, ceased during the ischemic rest period, and was activated more quickly in the second bout. Because the onset in both bouts occurred at approximately the same [Pi], ADP concentration, and AMP concentration, the activation of glycolysis appears to be related to the elevation of these metabolite concentrations. However, because no glycolytic flux occurred at rest, even when metabolite levels were high, both muscle activity and elevated metabolites are needed to turn on this pathway. We conclude that the delayed onset of glycolytic flux during exercise reflects the time needed to raise metabolites to flux-activating levels.
Radiation Doses to Staff in a Nuclear Medicine Department

Objectives: To measure external radiation doses and estimate internal radiation doses (due to the process of radionuclide injection) to staff members working in a nuclear medicine department over a 1-year period; to assess the possible radiation doses to staff members in order to determine whether classification of radiation workers is necessary. Methods: Radiation doses to 4 nuclear medicine physicians, 8 radiographers, and 2 laboratory attendants were measured by digital pocket dosimeters. Results: After correction for background natural radiation dose, the mean annual radiation dose to the physicians was 0.29 ± 0.21 mSv. This was lower than the mean annual radiation dose of 2.07 ± 0.97 mSv (p = 0.017) to the radiographers and 1.97 ± 0.05 mSv (p = 0.064) to the laboratory attendants, respectively. The mean radiation dose to the radiographers performing data acquisition and radionuclide injection (1.82 ± 1.08 mSv) was not different from that of the radiographers performing data acquisition only (2.53 ± 0.47 mSv) [p = 0.439]. An empirical formula was applied to compute the possible risk of receiving an internal dose in the process of radionuclide injection. The annual internal radiation dose to individual staff members performing radionuclide injection was estimated to be 0.01 mSv, which can be considered negligible in an estimation of total effective dose. Conclusions: This 1-year study showed that effective radiation doses to nuclear medicine department staff members were within permissible levels, and that the classification of radiation workers is unlikely to be necessary in a typical nuclear medicine department in Hong Kong.
Patient-specific Patellofemoral Arthroplasty

In the past few years, there has been renewed interest in patellofemoral arthroplasty. Although the results of off-the-shelf patellofemoral prostheses have varied, the researchers' results with patient-specific patellofemoral arthroplasty are encouraging. Our experience shows that patient-specific patellofemoral arthroplasty is a safe and effective treatment option for patients who have isolated end-stage patellofemoral arthritis. The surgical technique for patient-specific patellofemoral arthroplasty is straightforward because positioning and alignment of the patient-specific trochlear prosthesis are determined preoperatively, thus eliminating intraoperative guesswork. This paper describes the technique of patellofemoral arthroplasty that incorporates a custom-designed patient-specific prosthesis for resurfacing of the patellofemoral trochlea.