Miracle-dz/UniFAR-FTUs huggingface dataset:
Addiction: Treatment and Outcome

Traditional views of drug addiction have been pessimistic about outcome, suggesting that people who become dependent upon drugs seldom give up and that treatment has little effect. An editorial in the first edition of the International Journal of the Addictions stated that there is no relationship between treatment and outcome, and that 'the great majority of addicts simply resume drug use". Similarly, a review of treatment evaluation studies noted that 'the treatment of heroin addiction has been singularly unsuccessful'2. There are, however, two important but separate issues here. The first is whether or not people who are addicted to drugs can successfully give up, and the second is what role is played by treatment in the process of giving up.
Unintentional Acetaminophen Ingestion in Children and the Potential For Hepatotoxicity

Objective: Children who unintentionally ingest acetaminophen are often referred to health care facilities for evaluation. Criteria for referral are not well defined and the vast majority of these exposures result in nontoxic serum concentrations. The objective of this study was to determine the incidence of potentially hepatotoxic serum concentrations and to more clearly define referral criteria for these patients.Methods: A prospective evaluation of all childhood (age 1–72 months) single ingestions of acetaminophen-containing products was performed by the Utah Poison Control Center. All patients ingesting 140 mg/kg or greater or an unknown amount were referred for medical evaluation. Patients who ingested greater than 100 mg/kg were advised to administer syrup of ipecac at home if less than 1 hour since ingestion. Activated charcoal was recommended within 2 hours of ingestion if the patient was already at a health care facility. The potential for hepatotoxicity was assessed according to the Rumack-Matthew nomogram. Results: Inclusion criteria were met by 1015 patients. The mean age was 28 ± 12 months and mean dose was 213 ± 148 mg/kg. Decontamination with ipecac, gastric lavage, or activated charcoal within 2 hours of ingestion occurred in 81% of patients ingesting greater than 140 mg/kg or an unknown amount. Six patients (0.59%, 95% CI 0.12–1.16%) had “possible” or “probable” hepatotoxic serum concentrations and all had ingested greater than 200 mg/kg or an unknown amount. There were 423 patients who ingested between 100 and 200 mg/kg and none had potentially hepatotoxic serum concentrations (upper 95% CL 0.71%). Conclusions: Children who ingest between 140–200 mg/kg of acetaminophen and demonstrate ipecac-induced emesis within 60 minutes may be safely managed at home. Patients ingesting greater than 200 mg/kg or an unknown amount should be referred for a serum acetaminophen concentration.
Transmission of an Uncultivated Bergeyella Strain from the Oral Cavity to Amniotic Fluid in a Case of Preterm Birth

ABSTRACT Intrauterine infection is a recognized cause of preterm birth. The infectious organisms are believed to originate primarily from the vaginal tract and secondarily from other parts of the body. It is plausible that microbes in the oral cavity can be transmitted to the pregnant uterus. However, direct evidence supporting such a transmission is lacking. In this study, amniotic fluids of 34 pregnant women were examined by PCR using 16S and 23S rRNA universally conserved primers. Bacterial DNA was amplified from the only patient with clinical intrauterine infection and histologic necrotizing acute and chronic chorioamnionitis. One strain, Bergeyella sp. clone AF14, was detected and was 99.7% identical to a previously reported uncultivated oral Bergeyella strain, clone AK152, at the 16S rRNA level. The same strain was detected in the subgingival plaque of the patient but not in her vaginal tract. The 16S-23S rRNA sequence of clone AF14 matched exactly with the sequences amplified from the patient's subgingival plaque. These observations suggest that the Bergeyella strain identified in the patient's intrauterine infection originated from the oral cavity. This is the first direct evidence of oral-utero microbial transmission. The patient's periodontal health during pregnancy was unclear. She did not have detectable periodontal disease during postpartum examination. Bergeyella spp. had not been previously associated with preterm birth and were detected in subgingival plaque of women without clinical levels of intrauterine infection. Uncultivated species may be overlooked opportunistic pathogens in preterm birth. This study sheds new light on the implication of oral bacteria in preterm birth.
Impact of Knowledge Management Processes for Sustainability of Small Family Businesses: Evidences from the Brassware Sector of Moradabad (India)

In this research paper, we have studied the role and process of knowledge management in small family businesses at different stages of its growth: startup, business consolidation and succession. We intend to study if in family run MSME clusters education of firm owner gives any edge in the sustainability of the business. There is lack of availability of literature on study of Indian MSME with family business perspective. Our study encompasses factors that stimulate innovation, technology acquisition and business growth and sustainability. Evidences have been drawn from brass manufacturing cluster of Moradabad, Uttar Pradesh, India. The research is based on cross-case analysis of six brassware manufacturing units of Moradabad. We attempted to build on existing literature reviews on knowledge management process in family firms and assess how these theories fit in case of small family run export oriented enterprises, which are highly competitive. It was found family relationship, attitude to learn, critical thinking and social capital are keys in determining sustainability of these firms. A theoretical model has been curved out of the study.
4×4-element corporate-feed waveguide slot array antenna with cavities for the 120 GHz-band

We propose a 4×4-element corporate-feed waveguide slot array antenna with cavities for the 120 GHz band. In order to compensate the mutual coupling effects among neighbored slots, a cavity structure is employed for each radiating slot. As a result, broad bandwidth characteristic is achieved in a small-sized array. The reflection bandwidth is 12.0% for VSWR <; 1.5. The peak gain is 21.2 dBi with 80% antenna efficiency.
Image Segmentation by Probabilistic Bottom-Up Aggregation and Cue Integration

We present a parameter free approach that utilizes multiple cues for image segmentation. Beginning with an image, we execute a sequence of bottom-up aggregation steps in which pixels are gradually merged to produce larger and larger regions. In each step we consider pairs of adjacent regions and provide a probability measure to assess whether or not they should be included in the same segment. Our probabilistic formulation takes into account intensity and texture distributions in a local area around each region. It further incorporates priors based on the geometry of the regions. Finally, posteriors based on intensity and texture cues are combined using a mixture of experts formulation. This probabilistic approach is integrated into a graph coarsening scheme providing a complete hierarchical segmentation of the image. The algorithm complexity is linear in the number of the image pixels and it requires almost no user-tuned parameters. We test our method on a variety of gray scale images and compare our results to several existing segmentation algorithms.
Programmed Cell Death as a Mechanism of CD4 and CD8 T Cell Deletion in AIDS: Molecular Control and Effect of Highly Active Anti‐retroviral Therapy

Infection with human immunodeficiency virus (HIV) results in the progressive destruction of CD4 T lymphocytes, generally associated with progression of the disease. The progressive disappearance of CD4 T lymphocytes leads to the lack of control of HIV replication and to the development of severe immune deficiency responsible for the occurrence of opportunistic infections associated with AIDS. In this review we discuss premature lymphocyte apoptosis in the context of HIV infection as the consequence of the continuous production of viral proteins, leading to an unbalanced immune activation and to the triggering of apoptotic programs. The chronic immune activation induces the continuous expression of death factors which could turn lymphocytes, including CD4 T cells, CD8 CTL or APC, into effectors of apoptosis, leading to the destruction of healthy activated non‐infected cells. Thus, programmed cell death would significantly contribute to peripheral T cell depletion in AIDS, particularly if the Th cell renewal is impaired. Under potent anti‐retroviral therapies, a complete normalization of lymphocyte apoptosis is observed, concomitant with a partial restoration of the number and the functions of the immune system.
Fundamental Host Range of Pseudophilothnps ichini s.l. (Thysanoptera: Phlaeothripidae): A Candidate Biological Control Agent of Schinus terebinthifolius (Sapindales: Anacardiaceae) in the United States

ABSTRACT Schinus terebinthifolius Raddi (Sapindales: Anacardiaceae) is a non-native perennial woody plant that is one of the most invasive weeds in Florida, Hawaii, and more recently California and Texas. This plant was introduced into Florida from South America as a landscape ornamental in the late 19th century, eventually escaped cultivation, and now dominates entire ecosystems in south-central Florida. Recent DNA studies have confirmed two separate introductions of S. terebinthifolius in Florida, and there is evidence of hybridization. A thrips, Pseudophifothrips ichini s.l. (Hood) (Thysanoptera: Phlaeothripidae), is commonly found attacking shoots and flowers of S. terebinthifolius in Brazil. Immatures and occasionally adults form large aggregations on young terminal growth (stems and leaves) of the plant. Feeding damage by P. ichini s.l. frequently kills new shoots, which reduces vigor and restricts growth of S. terebinthifolius. Greenhouse and laboratory host range tests with 46 plant species in 18 families and 10 orders were conducted in Parana, Brazil, and Florida. Results of no-choice, paired-choice, and multiple-choice tests indicated that P. ichini s.l. is capable of reproducing only on S. terebinthifolius and possibly Schinus molle L. , an ornamental introduced into California from Peru that has escaped cultivation and is considered invasive. Our results showed that P. ichini s.l. posed minimal risk to mature S. molle plants or the Florida native Metopium toxiferum L. Krug and Urb. In May 2007, the federal interagency Technical Advisory Group for Biological Control Agents of Weeds (TAG) concluded P. ichini s.l. was sufficiently host specific to recommend its release from quarantine.
Branch-and-price global optimization for multiview multi-target tracking

We present a new algorithm to jointly track multiple objects in multi-view images. While this has been typically addressed separately in the past, we tackle the problem as a single global optimization. We formulate this assignment problem as a min-cost problem by defining a graph structure that captures both temporal correlations between objects as well as spatial correlations enforced by the configuration of the cameras. This leads to a complex combinatorial optimization problem that we solve using Dantzig-Wolfe decomposition and branching. Our formulation allows us to solve the problem of reconstruction and tracking in a single step by taking all available evidence into account. In several experiments on multiple people tracking and 3D human pose tracking, we show our method outperforms state-ofthe-art approaches.
Pharmacist staffing, technology use, and implementation of medication safety practices in rural hospitals.

CONTEXT Medication safety is clearly an important quality issue for rural hospitals. However, rural hospitals face special challenges implementing medication safety practices in terms of their staffing and financial and technical resources. PURPOSE This study assessed the capacity of small rural hospitals to implement medication safety practices, with particular focus on pharmacist staffing and the availability of technology. METHODS A telephone survey of a national random sample of small rural hospitals was conducted from March to May 2005 (N = 387 hospitals, 94.6% response rate). Survey respondents included pharmacists (89%) and directors of nursing (11%). Multivariate analyses examined the relationships between hospital organizational and financial variables and (1) the amount of pharmacist staffing; (2) use of pharmacy computers for medication safety activities; and (3) implementation of medication safety practices. FINDINGS Many small rural hospitals have limited hours of on-site pharmacist coverage. Almost one quarter of hospitals either do not have a pharmacy computer or are not using it for clinical purposes. Half of the hospitals have implemented 4 key medication safety practices. Level of pharmacist staffing, use of technology, and implementation of medication safety practices are significantly related to hospital financial status and accreditation. CONCLUSIONS Implementation of protocols related to medication use and key medication safety practices are areas where small rural hospitals could improve. The study results support a continuation of Medicare cost-based reimbursement policies to help ensure financial stability and support quality and patient safety activities in small rural hospitals.
Constitutive Activation of Nuclear Factor κB Contributes to Cystic Fibrosis Transmembrane Conductance Regulator Expression and Promotes Human Cervical Cancer Progression and Poor Prognosis

Objective Cystic fibrosis transmembrane conductance regulator (CFTR) and nuclear factor κB (NF-κB) have been known to play important roles in the development and progression of many types of cancer including cervical cancer. The study aimed to verify the relevance and significance of CFTR and NF-κB expressions in cervical cancer tissues and cell lines. Methods The expressions of CFTR and NF-κB p65 were analyzed respectively by immunohistochemistry in total of 135 cervical tissue samples. The correlation to clinicopathologic characteristics and prognostic value was evaluated. The coexpression of CFTR and NF-κB was detected in cervical cancer cell lines. Nuclear factor κB signaling was inhibited by siRNA for NF-κB p65 and activated by stimulation of cells with interleukin β or tumor necrosis factor &agr;. Results We found both the membrane expression of CFTR and nuclear translocation of NF-κB p65 were progressively increased from normal cervical tissue, cervical intraepithelial neoplasm, to cervical cancer (overall R2 = 0.74, P < 0.001). Cystic fibrosis transmembrane conductance regulator expression and NF-κB activation were also positively associated with stage, histological grade, lymph node metastasis, and invasive interstitial depth. Multivariate analysis showed that coexpression of CFTR and NF-κB was an independent prognostic factor for survival (relative risk, 5.16; P = 0.003). Dual-immunofluorescence analysis showed CFTR and NF-κB were coexpressed in cervical cancer. Studies in vitro revealed that the expression levels of CFTR mRNA and protein were positively related to NF-κB activation. Conclusions Cystic fibrosis transmembrane conductance regulator and NF-κB were coexpressed in cervical cancer, and the activation of NF-κB mediated the expression of CFTR. Multivariate analysis revealed that coexpression of CFTR and NF-κB was associated with poor prognosis in patients with cervical cancer.
Dual-mode interaction between quercetin and DNA-damaging drugs in cancer cells.

BACKGROUND DNA-damaging drugs constitute standard chemotherapy regimen for advanced colorectal cancer. Here, the interactions between quercetin and 5-fluorouracil (5-FU), etoposide, and camptothecin were examined in cancer cells. MATERIALS AND METHODS HCT116 colorectal or PPC1 prostate cancer cells were treated with quercetin and the drugs. Clonogenicity assays, cell cycle profiles, and expressions of p53, p21, BAX, survivin and cyclin B1 proteins were used to examine the effects of the treatments. RESULTS Quercetin synergistically inhibited the clonogenicity of the wild-type cells, but inhibited the cell cycle effects of all the drugs tested. In p53-null cells, the combination of low dose 5-FU with up to 6 μM quercetin promoted clonogenic survival. Treatment of p53-wild-type cells with 50 μM quercetin reduced drug-induced up-regulation of p53, p21 and BAX. The combination of quercetin and the drugs also reduced the levels of cyclin B1 and survivin proteins. CONCLUSION While high doses of quercetin synergize with DNA-damaging agents, the effect of drug combination with quercetin is influenced by the effective doses and the p53 status of the cells.
Replication of GB Virus C (Hepatitis G Virus) in Interferon-Resistant Daudi Cells

ABSTRACT We previously reported that Daudi cells, a Burkitt’s lymphoma cell line, were capable of supporting productive infection of hepatitis C virus (HCV). During continual cultivation after HCV infection, the culture became resistant to interferons (IFNs). This resistant cell line, coded as H-903, was used as host cells for replication of GB virus C (GBV-C), also known as hepatitis G virus. GBV-C RNA was detected in the culture by reverse transcription-PCR for more than 130 days after inoculation, while it was detected for 44 days but not later in the parental IFN-sensitive Daudi cells. Productive infection of GBV-C in the H-903 system was confirmed by serially inoculating supernatants from infected cultures into uninfected cells. The viral E2 antigen was detected by immunofluorescence in the cells inoculated with the fifth passage of GBV-C. The presumed capsid-coding region of the viral genome in the inoculum, in the serially passaged virus, or in the virus produced by a long-term culture was only 16 amino acids long, suggesting that the GBV-C with a short core sequence was replication competent.
Obesity, Gravity, and Spread of Epidural Anesthesia

Epidural anesthesia was administered for cesarean section in 250 parturients using 20 ml of 0.75% bupivacaine administered at L3–4 with the patient in a sitting position for 5 minutes. Comparing the results with those obtained in a previous study in which parturients were kept horizontal at all times, it was found that the sitting position limited cephalad spread of anesthesia only in obese patients and that the decrease in spread was in proportion to the degree of obesity. The previous findings that cephalad spread is positively correlated to body mass index BMI (weight in kilograms divided by height in meters squared) and with body weight were confirmed.
The use of expandable metal stents to facilitate extubation in patients with large airway obstruction.

OBJECTIVE To determine the clinical utility of placing airway stents to facilitate weaning in ventilator-dependent patients with large airway obstruction. METHODS A chart review of mechanically ventilated patients who received expandable metal airway stents to attempt a facilitation of weaning. RESULTS Eight patients, 3 women and 5 men, ranging in age from 37 to 82 years, had respiratory failure associated with large airway obstruction and underwent flexible bronchofluoroscopic placement of 12 expandable metal stents (7 Wallstents [Schneider; Minneapolis, MN], 2 Palmaz [Johnson & Johnson; Warren, NJ], and 3 Ultraflex [Microinvasive; Natick, MA]). Six had respiratory failure that was secondary to malignant airway disease, and two had benign airway disease. Seven patients with tracheal or mainstem bronchial obstruction were weaned from the ventilator within 0 to 11 days of stent placement after having previously required mechanical ventilation from 2 to 52 days. There were no associated complications. Following prolonged attempts at weaning, one patient with lobar bronchus obstruction died after mechanical ventilation was withdrawn. CONCLUSIONS Expandable metal airway stents may be safely deployed in mechanically ventilated patients and can facilitate weaning from the mechanical ventilator. Mechanically ventilated patients with tracheal and mainstem bronchus obstruction are the best candidates for deployment of expandable airway stents to facilitate weaning.
Ribosome Association Contributes to Restricting mRNAs to the Cell Body of Hippocampal Neurons

In neurons, mRNAs are differentially sorted to axons, dendrites, and the cell body. Recently, regions of certain mRNAs have been identified that target those mRNAs for translocation to the processes. However, the mechanism by which many, if not most mRNAs are retained in the cell body is not understood. Total inhibition of translation, by puromycin or cycloheximide, results in the mislocalization of cell body mRNAs to dendrites. We have examined the effect of translational inhibitors on the localization of ferritin mRNA, the translation of which can also be inhibited specifically by reducing iron levels. Using nonisotopic in situ hybridization, ferritin mRNA is found restricted to the cell body of cultured rat hippocampal neurons. Following treatment with either puromycin or cycloheximide, it migrates into dendrites. Control experiments reveal that the drugs affect neither the viability of the neuronal cultures, nor the steady-state level of ferritin mRNA. When transcription and protein synthesis are inhibited simultaneously, ferritin mRNA is found in the dendrites of puromycin, but not of cycloheximide-treated neurons. However, the localization of ferritin mRNA is unaffected by changes in iron concentration that regulate its translation rate specifically. We propose a model whereby cell body-restricted mRNAs are maintained in that location by association with ribosomes and with another cell component, which traps mRNAs when they are freed of ribosome association. The release of all mRNA species, as happens after total protein synthesis inhibition, floods the system and allows cell body mRNAs to diffuse into dendrites. In contrast, the partial release of the single ferritin mRNA species does not saturate the trapping system and the mRNA is retained in the cell body.
Measuring Community-Based Participatory Research Partnerships: The Initial Development of an Assessment Instrument

Background: Although the partnership between academic researchers and community members is paramount to community-based research efforts, a limited number of measures exist to evaluate this construct. Of those in existence, no assessment measures include a comprehensive coverage of the many dimensions of partnerships. In addition, these measures were not designed through an extensive community-based participatory research (CBPR) model, in which the strengths of traditional assessment techniques were integrated with input from stakeholders.Objectives: The purpose of this article was to describe the creation of a measure to evaluate key dimensions of partnerships forged between researchers and community members using a CBPR approach to measurement development.Methods: The iterative process of developing this measure consisted of integrating valuable feedback from community partners and researchers, via multiple rounds of item sorting and qualitative interviewing.Results: The resultant measure, titled Partnership Assessment In community-based Research (PAIR), consists of 32 items, and comprises 5 dimensions: communication, collaboration, partnership values, benefits, and evaluation. The innovative process of using CBPR in the development of measures, the benefits of this approach, and the lessons learned are highlighted.Conclusions: PAIR was developed out of a need identified jointly by community members and researchers, and is intended to characterize the range of relationships between researchers and community members engaging in community-based research and programming.