Miracle-dz/UniFAR-FTUs huggingface dataset:
The manager's dilemma: a conceptualization of online review manipulation strategies

Online evaluations are one of the most important innovations in tourism in recent years, often combining a review/rating (business-specific evaluation) and a ranking (inter-business comparison). As online reputation determines economic success, tourism managers may be tempted to manipulate online content. This paper presents the results from a qualitative study involving 20 hotel managers in southern Sweden, and their perspectives on manipulation. Results confirm that there exists a wide range of review manipulation strategies, many of which are difficult to control. Even though only few managers appear to systematically manipulate, online evaluations represent a significant challenge for businesses, as they introduce direct competition and foster consumer judgement cultures. It is postulated that managers will increasingly find themselves in a Prisoner's dilemma, representing a situation where engaging in manipulation is the most rational choice in an increasingly competitive market situation.
Structural and Mechanistic Features of Protein O Glycosylation Linked to CD8+ T-Cell Apoptosis

ABSTRACT CD8+ T-cell apoptosis is essential for the contraction phase of the immune response, yet the initiating signals and precise pathways involved are unresolved. The ST3Gal-I sialyltransferase is a candidate mechanistic component and catalyzes sialic acid addition to core 1 O-glycans during protein O glycosylation. ST3Gal-I inactivation or enzymatic removal of its product renders CD8+ T cells, but not CD4+ T cells, susceptible to apoptosis by differential cross-linking of O-glycoproteins in the absence of interleukin-2 and T-cell receptor (TCR) signaling. This results in caspase activation, DNA fragmentation, and phosphatidylserine externalization prior to cell death. We further show that ST3Gal-I function is regulated by a posttranscriptional mechanism operating distal to Golgi core 2 O glycosylation and is invariably linked to CD8+ T-cell contraction following viral (lymphocytic choriomeningitis virus) infection and bacterial (staphylococcal enterotoxin B) antigen immunization. The mechanism does not involve the ST3Gal-I substrate CD43 or core 2 O-glycan induction and overcomes the ability of Bcl-2 to inhibit the contraction phase in vivo. Loss of ST3Gal-I function further reduces Bim-deficient CD8+ T-cell accumulation without diminishing apoptotic sensitivity. We propose that an endogenous lectin activates an apoptotic pathway constructed in CD8+ T cells following TCR stimulation and enables contraction upon attenuation of immune signaling.
A Small Fibronectin-mimicking Protein from Bacteria Induces Cell Spreading and Focal Adhesion Formation*

Fibronectin, a 250-kDa eukaryotic extracellular matrix protein containing an RGD motif plays crucial roles in cell-cell communication, development, tissue homeostasis, and disease development. The highly complex fibrillar fibronectin meshwork orchestrates the functions of other extracellular matrix proteins, promoting cell adhesion, migration, and intracellular signaling. Here, we demonstrate that CagL, a 26-kDa protein of the gastric pathogen and type I carcinogen Helicobacter pylori, mimics fibronectin in various cellular functions. Like fibronectin, CagL contains a RGD motif and is located on the surface of the bacterial type IV secretion pili as previously shown. CagL binds to the integrin receptor α5β1 and mediates the injection of virulence factors into host target cells. We show that purified CagL alone can directly trigger intracellular signaling pathways upon contact with mammalian cells and can complement the spreading defect of fibronectin−/− knock-out cells in vitro. During interaction with various human and mouse cell lines, CagL mimics fibronectin in triggering cell spreading, focal adhesion formation, and activation of several tyrosine kinases in an RGD-dependent manner. Among the activated factors are the nonreceptor tyrosine kinases focal adhesion kinase and Src but also the epidermal growth factor receptor and epidermal growth factor receptor family member Her3/ErbB3. Interestingly, fibronectin activates a similar range of tyrosine kinases but not Her3/ErbB3. These findings suggest that the bacterial protein CagL not only exhibits functional mimicry with fibronectin but is also capable of activating fibronectin-independent signaling events. We thus postulate that CagL may contribute directly to H. pylori pathogenesis by promoting aberrant signaling cross-talk within host cells.
Functional neuroanatomical investigation of vision‐related acupuncture point specificity—A multisession fMRI study

The concept that specific acupuncture points have salubrious effects on distant target organ systems is a salient feature of Traditional Chinese Medicine (TCM). In this study, we used a multiple‐session experiment to test whether electroacupuncture stimulation at two TCM vision‐related acupoints, UB 60 and GB 37, located on the leg, could produce fMRI signal changes in the occipital regions of the brain, and the specificity of this effect when compared with stimulation at an adjacent non‐acupoint (NAP). Six normal, acupuncture naïve subjects completed the study. Each subject participated in six identical scanning sessions. Voxelwise group analysis showed that electroacupuncture stimulation at both vision‐related acupoints and the NAP produced modest, comparable fMRI signal decreases in the occipital cortex, including the bilateral cuneus, calcarine fissure and surrounding areas, lingual gyrus, and lateral occipital gyrus. Further analysis of fMRI signal changes in occipital cortex showed no significant difference among the three points, UB 60, GB 37, and NAP. Our results thus do not support the view that acupuncture stimulation at vision‐related acupoints induces specific fMRI blood oxygen level dependent (BOLD) signal changes in the occipital cortex. We speculate that cross modal inhibition, produced by needling‐evoked somatosensory stimulation, may account for our finding of BOLD signal decreases in the occipital cortex. Given the complexity of acupuncture systems and brain activity, additional work is required to determine whether functional neuroanatomical correlates of acupoint specificity can be validated by means of brain imaging tools. Hum Brain Mapp 2009. © 2007 Wiley‐Liss, Inc.
Public Finances, Business Cycles and Structural Fiscal Balances

This paper proposes a new framework to analyze and estimate structural fiscal balances. Stochastic trends are properly incorporated, and the numerical solution of the DSGE model serves as part of the Kalman smoother to extract structural fiscal balances. For the UK, a setting of an integrated random walk for the underlying stochastic trends fits the date best. The response of nominal fiscal revenue to the technology shock is small. The shocks to foreign demand and to foreign goods price both have positive effects on fiscal revenue. An expansionary monetary policy shock has a great positive short-run impact on fiscal revenue, but the influence is not persistent because of the open-economy characteristic of the UK. An expansion in government spending can also increase fiscal revenue, but the effect is not persistent as well due to the domestic and external crowd-out effects. A contractionary fiscal policy (cutting government expenditure or increasing the lump-sum tax temporarily), rather than an expasionary one, will benefit economic recovery and also improve fiscal stance. Compared to a temporary increase of the lump-sum tax, cutting government spending is relatively more effective and it alleviates the two kinds of crowd-out effects.
Polymorphically duplicated genes: their relevance to phenotypic variation in humans

A number of disorders are known to be caused by duplication of genes, but these are all rare events. However, there is evidence that polymorphic gene duplication may be common and a growing number of genes are known to be duplicated in a polymorphic manner although phenotypes cannot be associated with most of these. Gene duplication occurring due to cytogenetic abnormalities such as Down syndrome predisposes the patients to a variety of complex disorders. It is possible therefore that many complex disorders and variable phenotypes are associated with duplication of genes.
Blind source separation of peripheral nerve recordings

Prosthetic devices can be controlled using signals recorded in parts of the body where sensation and/or voluntary movement have been retained. Although neural prosthetic applications have used single-channel recordings, multiple-channel recordings could provide a significant increase in useable control signals. Multiple control signals can be acquired from recordings of a single implant by using a multi-contact electrode placed over a multi-fasciculated peripheral nerve. These recordings can be separated to recover the individual fascicular signals. Blind source separation (BSS) algorithms have been developed to extract independent source signals from recordings of their mixtures. The hypothesis that BSS algorithms can recover individual fascicular signals from nerve cuff recordings at physiological signal-to-noise ratio (SNR ∼ 3–10 dB) was investigated in this study using a finite-element model (FEM) of a beagle hypoglossal nerve with a flattening interface nerve electrode (FINE). Known statistical properties of fascicular signals were used to generate a set of four sources from which the neural signals recorded at the surface of the nerve with a multi-contact FINE were simulated. Independent component analysis (ICA) was then implemented for BSS of the simulated recordings. A novel post-ICA processing algorithm was developed to solve ICA's inherent permutation ambiguities. The similarity between the estimated and original fascicular signals was quantified by calculating their correlation coefficients. The mean values of the correlation coefficients calculated were higher than 0.95 (n = 50). The effects of the geometric layout of the FINE electrode and noise on the separation algorithm were also investigated. The results show that four distinct overlapping fascicular source signals can be simultaneously recovered from neural recordings obtained using a FINE with five or more contacts at SNR levels higher than 8 dB making them available for use as control signals.
The effect of real-time fiscal policy on sovereign interest rates in OECD countries

The aim of this study is to investigate the effect of real-time projections of fiscal policy stances on government bonds long-term interest rates using a panel of 20 OECD countries between 1992 and 2008. To deal with endogeneity arising from forecasts of fiscal balances the paper exploits instrumental variables and GMM estimators together with the variation in real-time primary balances. The study shows how a static specification that does not include the one-period lag of the interest rate is prone to serial correlation and to downward bias in standard errors. To correct the bias, a dynamic specification with the lagged interest rates used as explanatory variable should be used due to the intrinsic persistent behavior of the interest rates. Results show that when the persistency of the interest rates is taken into account, it corrects the bias in standard errors of the estimates, and the correlation between fiscal policy variables and sovereign rates disappears: the inertia of the behavior of interest rates is the only variable affecting the relation.
Alanine Substitutions of Polar and Nonpolar Residues in the Amino-Terminal Domain of CCR5 Differently Impair Entry of Macrophage- and Dualtropic Isolates of Human Immunodeficiency Virus Type 1

ABSTRACT Multiple extracellular domains of the CC-chemokine receptor CCR5 are important for its function as a human immunodeficiency virus type 1 (HIV-1) coreceptor. We have recently demonstrated by alanine scanning mutagenesis that the negatively charged residues in the CCR5 amino-terminal domain are essential for gp120 binding and coreceptor function. We have now extended our analysis of this domain to include most polar and nonpolar amino acids. Replacement of alanine with all four tyrosine residues and with serine-17 and cysteine-20 decrease or abolish gp120 binding and CCR5 coreceptor activity. Tyrosine-15 is essential for viral entry irrespective of the test isolate. Substitutions at some of the other positions impair the entry of dualtropic HIV-1 isolates more than that of macrophagetropic ones.
Job Sector Choice and Public Service Motivation: Evidence from Colombia

In this article I examine the determinants of job sector choice with a particular interest in the relationship with the so-called concept of public service motivation (PSM), in the context of a developing country. I use multinomial logit (MNL) to understand individuals’ decisions to take jobs in one of four sectors: government, nonprofit, for-profit, or academic jobs in Colombia. My analysis is based on data about a sample of participants on the Colombian scholarship program, Colfuturo, drawn from between 2002 and 2007. My results indicate that there are important differences in terms of the determinants of job sector choices across the four different sectors and that PSM appears to have a role on such decisions.
Endogenous Contagion: A Panel Analysis

This paper proposes a panel data model to analyze contagion in a multivariate framework. The model distinguishes between vulnerability and contagion, and provides a time series of contagion. The most important feature of the model is the endogenous determination of contagion without an a priori and potentially arbitrary specification of the crisis period. In addition, the model can distinguish between positive and negative contagion, and no assumption needs to be made about the source of the crisis. Eleven stock markets from the Asian region are analyzed during the Asian financial crisis, and contagion is found to be significant in four broad periods. These episodes are split equally between positive and negative movements. Anecdotal evidence is matched to the significant incidences of contagion, and it is found that events surrounding Hong Kong equity markets are key drivers of contagion. JEL classification: C10, C51, F36, G14
Motor performance deteriorates with simultaneously performed cognitive tasks in geriatric patients.

OBJECTIVE To investigate whether simultaneous cognitive tasks influence maximal motor performance in frail geriatric patients with a history of injurious falls and different levels of cognitive function. DESIGN Experimental 3-group design. SETTING Geriatric rehabilitation hospital. PARTICIPANTS Twenty-two healthy, young adults (mean age +/- standard deviation, 27.7 +/- 9y) and 23 geriatric patients (mean age, 80.9 +/- 5.4y) with a history of injurious falls with (Mini-Mental State Examination [MMSE] score, 20.5 +/- 1.6) and without (MMSE score, 28.1 +/- 1.2) cognitive impairment. INTERVENTIONS Not applicable. MAIN OUTCOME MEASURE Motor performance: peak and integral of maximal isometric strength of leg extensors. Cognition: semiautomated calculation steps (serial 2 forward) and nonautomated calculation steps derived from the MMSE (serial 7 retro). Motor and cognitive performances were examined as single and dual tasks. RESULTS In frail geriatric patients, especially in patients with cognitive impairment, maximal motor performance decreased significantly during all dual tasks. Cognitive performance was reduced, depending on the task and group. CONCLUSION In frail or cognitively impaired geriatric patients, additional tasks can substantially decrease maximal motor performance. Insufficient resources on dual tasking may thus be a link in connecting the high incidence of falls with frailty and cognitive impairment in geriatric patients with a history of injurious falls.
Functional Analysis of the Pyrimidine de Novo Synthesis Pathway in Solanaceous Species1

Pyrimidines are particularly important in dividing tissues as building blocks for nucleic acids, but they are equally important for many biochemical processes, including sucrose and cell wall polysaccharide metabolism. In recent years, the molecular organization of nucleotide biosynthesis in plants has been analyzed. Here, we present a functional analysis of the pyrimidine de novo synthesis pathway. Each step in the pathway was investigated using transgenic plants with reduced expression of the corresponding gene to identify controlling steps and gain insights into the phenotypic and metabolic consequences. Inhibition of expression of 80% based on steady-state mRNA level did not lead to visible phenotypes. Stepwise reduction of protein abundance of Asp transcarbamoylase or dihydro orotase resulted in a corresponding inhibition of growth. This was not accompanied by pleiotropic effects or by changes in the developmental program. A more detailed metabolite analysis revealed slightly different responses in roots and shoots of plants with decreased abundance of proteins involved in pyrimidine de novo synthesis. Whereas in leaves the nucleotide and amino acid levels were changed only in the very strong inhibited plants, the roots show a transient increase of these metabolites in intermediate plants followed by a decrease in the strong inhibited plants. Growth analysis revealed that elongation rates and number of organs per plant were reduced, without large changes in the average cell size. It is concluded that reduced pyrimidine de novo synthesis is compensated for by reduction in growth rates, and the remaining nucleotide pools are sufficient for running basic metabolic processes.
Insurance market development and economic growth: Exploring causality in 8 selected African countries

Purpose - – The purpose of this paper is to examine the causal relationship between insurance penetration and economic growth in eight selected African countries. Design/methodology/approach - – The auto-regressive distributed lags bounds approach to cointegration is employed on annual time-series data from 1990 to 2010 to test the causal relationship between insurance and economic growth in Algeria, Gabon, Kenya, Madagascar, Mauritius, Morocco, Nigeria and South Africa. The ratio of life and non-life insurance premiums to gross domestic product are employed as proxies for insurance market development. Findings - – The results of the bound test shows a long-run relationship between insurance market activities and economic growth for Kenya, Mauritius, Morocco, Nigeria and South Africa. Causality analysis within the vector error correction model indicates a uni-directional causality from insurance market development to economic growth except for Morocco where there is evidence of a bi-directional causality. Causality within the vector autoregressive framework also provides evidence of a uni-directional causality for Algeria and Madagascar to support the “supply-leading” hypothesis while mixed causality was found for Gabon. Practical implications - – This findings provides policy direction for governments and regulatory authorities for developing insurance market in the sample countries. Originality/value - – This is the first study to examine the finance-growth relationship from the perspective of insurance markets in a cross-section of African countries.
An International Survey of Drug Information Centers

A questionnaire was developed to characterize the location, operation, personnel, reference resources, and functions of drug information centers in countries throughout the world other than the United States. The questionnaire was mailed to 100 drug information centers or pharmacy practitioners (primarily faculty) in 65 countries. The majority of drug information centers responding to this questionnaire were located at and funded by university based hospitals. Most were open eight hours per day and engaged in the following activities: answering requests for information, publishing pharmacy bulletins, teaching, continuing education, and providing information directly to pharmacy and therapeutics committees. Additional information gathered from this survey included: common references and journals maintained by drug information centers, user demographics, and a request profile. Although many similarities among the information centers were found, interesting observations regarding their differences may be made. It is important that drug information centers share their experiences so that others may learn about their new and innovative programs.
Centralising rents and dispersing power while pursuing development? Exploring the strategic uses of military firms in Rwanda

ABSTRACT The Rwandan Patriotic Front has achieved significant economic progress while also maintaining political stability. However, frictions among ruling elites have threatened progress. This paper explores the use of military firms in Rwanda. Such firms are used to invest in strategic industries, but the use of such firms reflects the vulnerability faced by ruling elites. Military firms serve two related purposes. First, ruling elites use such firms to centralise rents and invest in strategic sectors. Second, the proliferation of such enterprises and the separation of party- and military-owned firms contribute to dispersing power within a centralised hierarchy.
Application of dynamic diffractive optics for enhanced femtosecond laser based cell transfection

We demonstrate the advantages of a dynamic diffractive optical element, namely a spatial light modulator (SLM) for the controlled and enhanced optoinjection and phototransfection of mammalian cells with a femtosecond light source. The SLM provides full control over the lateral and axial positioning of the beam with sub‐micron precision. Fast beam translation enables time‐sequenced irradiation, which is shown to enhance the optoinjection efficiency and alleviate the problem of exact beam positioning on the cell membrane. We show that irradiation in three axial positions doubles the number of viably optoinjected cells when compared with a single dose. The presented system also enables untargeted raster scan irradiation which provides a higher throughput transfection of adherent cells at the rate of 1 cell per second. Additionally, fluorescent imaging is used to demonstrate cell selective two‐step gene therapy. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)