Miracle-dz/UniFAR-FTUs huggingface dataset:
The Role of the N‐Terminal Domain in the Regulation of the “Constitutively Active” Conformation of Protein Kinase CK2α: Insight from a Molecular Dynamics Investigation

Protein kinase CK2 is an extremely well‐conserved pleiotropic protein kinase with a growing list of substrates, the majority of which are proteins implicated in signal transduction, gene expression, and transcription‐related functions. Protein kinase CK2 is a ubiquitous heterotetrameric serine/threonine protein kinase made up of two α or α’ catalytic subunits and two β regulatory subunits. Moreover, protein kinase CK2 is defined as a “constitutively active” protein kinase in contrast to most other protein kinases characterized by the presence of distinct conformations associated with the active and inactive states. As previously demonstrated by in vitro mutation studies, CK2 activity is substantially regulated by the interaction between the N‐terminal tail and the kinase domain. In fact, progressive deletions of the N‐terminal tail show a decrease in the activity of the kinase. Even if the detrimental effects of Δ2–12 deletion can be partially reversed by the addition of a CK2β subunit, deletions Δ2–12 and Δ2–30 progressively decrease the basal activity of CK2. In particular, as experimentally demonstrated, the Δ2–12 N‐terminal deletion affects both the KM value for ATP and for the substrate peptide, and the kcat value of CK2α. In this work, molecular dynamics (MD) simulations were carried out on wild‐type (wt), Δ2–12 and Δ2–30 deletion mutants of CK2α in order to explore the role of the N‐terminal tail on the conformational behavior of CK2. Furthermore, classical MD simulations were carried out to assess the anticipated impact of conformational changes in a novel set of CK2α mutant forms, such as the triple mutant Y206F‐R10A‐Y261F and the single mutant Y125F.
Stretchable and Robust Candle-Soot Nanoparticle-Polydimethylsiloxane Composite Films for Laser-Ultrasound Transmitters

Considerable attention has been devoted to the development of nanomaterial-based photoacoustic transmitters for ultrasound therapy and diagnosis applications. Here, we fabricate and characterize candle-soot nanoparticles (CSNPs) and polydimethylsiloxane (PDMS) composite-based photoacoustic transmitters, based on a solution process, not just to achieve high-frequency and high-amplitude pressure outputs, but also to develop physically stretchable ultrasound transmitters. Owing to its non-porous and non-agglomerative characteristics, the composite exhibits unique photo-thermal and mechanical properties. The output pressure amplitudes from CSNPs–PDMS composites were 20–26 dB stronger than those of Cr film, used as a reference. The proposed transmitters also offered a center frequency of 2.44–13.34 MHz and 6-dB bandwidths of 5.80–13.62 MHz. Importantly, we characterize the mechanical robustness of CSNPs–PDMS quantitatively, by measuring laser-damage thresholds, to evaluate the upper limit of laser energy that can be ultimately used as an input, i.e., proportional to the maximum-available pressure output. The transmitters could endure an input laser fluence of 54.3–108.6 mJ·cm−2. This is 1.65–3.30 times higher than the Cr film, and is significantly higher than the values of other CSNPs–PDMS transmitters reported elsewhere (22–81 mJ·cm−2). Moreover, we characterized the strain-dependent photoacoustic output of a stretchable nanocomposite film, obtained by delaminating it from the glass substrate. The transmitter could be elongated elastically up to a longitudinal strain of 0.59. Under this condition, it maintained a center frequency of 6.72–9.44 MHz, and 6-dB bandwidth ranges from 12.05 to 14.02 MHz. We believe that the stretchable CSNPs–PDMS composites would be useful in developing patch-type ultrasound devices conformally adhered on skin for diagnostic and therapeutic applications.
Influence of Socio-economic characteristics of irrigation farmers to access and utilization of agricultural knowledge and information.

The study investigated the influence of socio-economic characteristicsof irrigation farmer’s access to and utilization of agricultural information in North Western Nigeria. A questionnaire survey of 368 households in three (3) states in North Western Nigeria was used. The objectives of the study is: To identify the extent to which some socio-economic variables of irrigation farmers affects their utilization of agricultural information; to highlight how the socio-economic variables could help in determining the type of information needed. Using the Diffusion of Innovation paradigm of Rogers, multiple regression, correlation coefficient and Chi-square analysis, the results of the study suggest that age, sex, experience, educational status and belonging to farmers association have significant relationship on access to and utilization of agricultural information by the irrigation farmers.However, a critical gap still needs to be filled by the research extension services in combining the technical and socio-economics aspects of irrigation farming in order to boost the country’s food production and food security.
Pastoral Group Counselling at a High Security Prison in Israel: Integrating Pierre Janet’s Psychological Analysis with Fritz Perls’ Gestalt Therapy

This is a report of a short-term, pastoral counselling group conducted with Jewish internees in a high security prison in Israel. It was held as an adjunct to daily secular individual and group counselling and rehabilitation run by the Department of Social Work. Pastoral counselling employed spiritual and psychosocial methodologies to reduce anger, improve prisoner frustration tolerance, and develop a sense of self-efficacy and communal identity. It combined semi-didactic scriptural input with Pierre Janet’s personality model, Fritz Perls’ gestalt therapy, and analysis of the group process.
Social and Environmental Disclosures and Holistic Growth in the Positive Accounting Theory (PAT) View

The objective of this study is to examine corporate social and environmental disclosure and holistic growth in the Positive Accounting Theory (PAT) view. Specifically, the paper investigates the relationship that exists between corporate social responsibility and Return on asset, leverage, and firm size. The data for this study were obtained from secondary source which were collected from the audited annual reports as well as accounts of the listed Deposit Money Banks in Nigeria. The paper is descriptive and highly empirical as it embraces the use of panel regression technique as tool of analysis. The regression analysis shows that corporate social and environmental is associated with: ROA, firm’ size, and leverage. Therefore, the outcomes confirm positive relationship between support the bonus plan hypothesis and political cost hypothesis, while association with debt/equity hypothesis is negative. The study recommends effective disclosure of corporate social responsibility as one of factors that brings about holistic growth.
REVA-based Value Analysis on Listed Companies of Power Industry

The paper establishes the regression model based on the economic value added(EVA), refined economic value added(REVA), net profit, net cash flow and other indicators selected from the financial data of power industry. Correlation analysis indicates that, in comparison with traditional financial indicators, EVA and REVA are more efficient in studying the value of China’s electric power enterprises. And the interpretation to enterprise value will be more persuasive when combining EVA, REVA with traditional financial indicators. The study also finds out that the interpretative power of EVA-related indicators to enterprise value has been gradually increasing over the past seven years. Keywords-economic value added; refined economic value added; market value added; enterprise value
Solid-State Tap Changers: New Configurations and Applications

Voltage regulation at the subtransmission and distribution levels strongly relies on the use of transformer tap changers, implemented these days with sophisticated yet fragile electromechanical mechanisms. The possibility of replacing mechanically operated switches by electronic devices has been the subject of much interest in the last few years. In this paper, a review of existing solid-state implementations is first made. Then, several alternative topologies are proposed and compared with those considered the best ones in terms of number of switches, number of auxiliary windings, number of switches in series and maximum blocking voltage. Finally, the application of the proposed schemes to distribution transformers, both at the primary and secondary levels, is addressed.
What's in A Website? E-Government Scores and Municipal Characteristics

In 2012, Monmouth University's Polling Institute and Monmouth University's Public Policy graduate program conducted an analysis of municipal websites throughout the state of New Jersey. The intention of the report was to provide municipal governments with a general idea of best practices as well as their position relative to other municipalities. While the initial report by Monmouth's Polling Institute conducted some summary analyses, this analysis unlocks some additional information about explaining the variation of website scores. Taking into account various demographic, budgetary, and political measures, this paper shows that various factors affect the quality of communication between government and citizens. Of particular interest is the effect of municipal partisanship, municipal government professionalism, and the use of referenda on website quality. Such an analysis fills a gap in the e-government literature. While previous studies have focused on various topics within e-government, less attention has been given to explaining the variation in the quality of these websites. By showing the impact of education, poverty, partisanship, government characteristics, budgetary constraints, and population, this analysis should be of import to scholars and policymakers alike.
The Effect of Organization Commitment, Human Resource, Regional Regulation, Infrastructure, and Information System on Regional Government Readiness in The Implementation of Accrual Accounting and Good and Clean Governance (GGC)

The regulations which born related with financial management has many implications and must be addressed well and early. The regulations which born related with financial management are including regulations on planning management and budgeting, budget implementation, reporting, accountability, internal information system and financial report examination. All of that regulations must be well addressed by regional governance. The purpose of this study are to acquire empirical proof on which factors that must be addressed and prepared by regional governance in order to implemented accrual accounting based financial report. The factors or variables that we tested are limited on organization commitment, human resource, regional regulation, infrastructure, and information system as independent variable on the dependent variable of regional government readiness in the implementation of regulations especially the ones related with accrual based accounting and good and clean governance (GGC). The results of this study reveal that organization commitment, infrastructure, information system, and regional regulation has a significant amount of impact on regional government implementation of accrual based accounting. Also, regional government readiness does not have any result on good and clean governance (GGC)
Measurement Issues in Comparing Fiscal Performance of States

Interstate comparison of fiscal performance requires use of appropriate concepts and proper measurement of state income, fiscal deficit and debt. GSDP at market prices and a comprehensive concept of debt consistent with the fiscal deficit of a state government are the right concepts to use for the purpose. The rating agencies and the Finance Commissions have not used the right concepts so far. Illustrative estimates for Gujarat show that it can lead to misleading target setting and wrong perceptions about the fiscal performance of the states. CSO, RBI and the rating agencies have to ensure that right concepts are used in interstate comparison.
Prescription privileges. Psychology's next frontier?

In the past 5 years there has been a growing interest among psychology practitioners in obtaining prescription privileges, and relevant policy documents have reflected increasing support from the APA. The nonphysician health manpower literature has demonstrated that a wide range of professionals can be trained to prescribe medications competently, while maintaining quality of care; within federal agencies, psychologists have legally prescribed medications. Ongoing debates in Hawaii and in the U.S. Department of Defense may be laying the foundation for psychology's training and practice agenda for the 1990s. Were psychologists to have this clinical privilege, many societal needs--including addressing the longstanding problems of excessive medication of elderly persons and quality care for the chronically mentally ill and for persons residing in rural areas--could be met.
How Do Self-Values Play a Role In Consumers' Perception of CSR Advertising?

ABSTRACT This study examined dynamic interactions among self-values leading consumers to self-reference corporate social responsibility (CSR) advertising sponsored by three industries: oil, juice, and pharmaceuticals. The findings revealed that when consumers highly valued businesses' involvement in social causes, their motives to impress others or increase status significantly affected purchase intentions via self-referencing CSR advertising. For highly issue-involved consumers who did not believe in a business's involvement in social causes, the status motive indirectly affected purchase intention through self-referencing in a negative direction when they viewed an oil company's CSR advertising. This finding was not present for CSR advertisements sponsored by the other industries.
Bereaved parents' perspectives on their needs

ABSTRACT Objective: The loss of a child can be traumatic for parents, given the profound bond established with the deceased child. Parental bereavement and the need for bereavement services are not well understood. This study examined parental perspectives regarding bereavement services from a pediatric oncology treating center. Methods: A 2-h focus group of seven parents, audiotaped and transcribed verbatim, was conducted by two facilitators using open-ended questions to generate discussion regarding their views of what services were or would be helpful during early bereavement. Results: Parents perceived flexible and continuous bereavement services from the treating hospital as a necessary transition to community services. Talking to other parents with similar experiences and maintaining contact with staff at the treating hospital were considered critical in their healing after the loss. Significance of results: Transitional multimodality bereavement services offered by the treating hospital will improve the quality of life of bereaved families.
'Ten golden rules' for designing software in medical education: results from a formative evaluation of DIALOG

Evaluation of educational material has become very important in a climate where there is increasing concern with assessing and maintaining quality. DIALOG (acronym for Distance Interactive Learning in Obstetrics and Gynaecology) is an electronic program on CD-ROM for continuing education. A formative evaluation of DIALOG was carried out to determine whether DIALOG was achieving its educational objectives. The results of the evaluation helped to suggest '10 golden rules' for designing software for the purpose of CPD for medical practitioners. These 'rules' should help in designing future software in medical education. They highlight the importance of content, presentation, design, use of hypermedia and multimedia and reduced cost in order to facilitate appropriate use of such programmes.
EFFECT OF THE ROLE OF SAFETY OFFICER ON COMPLIANCE TO OCCUPATIONAL SAFETY AND HEALTH (OSH) AMONG OUTSOURCING WORKERS IN COMPANY X, SURABAYA

Up to the end of 2012, Social Security showed the occurence of 103.074 work accident cases. 91.21% of the accident casualties were recovered, 3.8% were disabled, 2.61% partially disabled, and the rest died (2.419 cases) and were totally-permanently disabled (37 cases), with the average of 282 work accident cases per day. Due to the increasingly tight corporate climate, the company tries to make production cost efficiency (cost of production). One solution that may be taken is by applying outsourcing system. With this system, the company may save expenses in funding human resources (HR) who work in the company concerned. If the aspects of the application of Occupational Safety and Health (OSH) are not properly managed, the possibility of work accidents and environmental pollution that have a negative effect on the corporate image and the continuity of company product supply will increase. This may affect the company's loss, both material and corporate image. The role and responsibility of the safety officer is very influential on the achievement of zero accident, so many safety programs are developed, such as safety briefing and safety patrol, with the aim to improve the aspect of OSH. However, some employees have not complied with the provisions of OSH implementation in the company they work at.
The bisphosphonate alendronate (MK‐217) inhibits bone loss due to ovariectomy in rats

Estrogen deficiency in mammals is known to increase bone turnover and result in reduced bone mass. The bisphosphonate, 4‐amino‐1‐hydroxybutylidene‐1,1‐bisphophonic acid disodium salt, alendronate (MK‐217), is a potent inhibitor of bone resorption and was evaluated in this study for its ability to inhibit bone loss following ovariectomy in rats. Alendronate was administered sc in doses of 0.0, 0.056, 0.28, 1.40, and 7.0 mg P/kg/month, divided into two, four, or eight monthly subcutaneous injections for each dose, to female Sprague‐Dawley rats (250‐280 g) that underwent bilateral ovariectomy. Rats were sacrificed 12 weeks postovariectomy, the femora ashed, and the tibiae prepared for static and dynamic histomorphometric analyses.
Relationships among the nurse work environment, self-nurturance and life satisfaction.

AIM This paper is a report of a study to (1) ascertain the relationship among self-nurturance, perceived Magnet features and life satisfaction and (2) evaluate the predictive effects of self-nurturance and Magnet features on life satisfaction. BACKGROUND Promoting health is a global priority for nurses and for the public who depend upon them to provide quality care. Health gains can be realized by modifying the work environment and by modifying lifestyle choices (self-nurturance). A study of nurses that examined perceptions of workplace features that enable nurses' professional practice (Magnet features), self-nurturance and healthy outcomes (life satisfaction) was not found in the literature. METHODS Survey data collected in May 2003 from a convenience sample of 310 Registered Nurses were used for this descriptive, correlational study. FINDINGS Self-nurturing nurses were more satisfied with life and perceived that more Magnet features were present in the workplace. Nurses with a master's degree were more self-nurturing than nurses without a baccalaureate degree. The synergistic effect of both self-nurturance and workplace factors predicted 29% of variance in nurses' life satisfaction. CONCLUSION Higher levels of perceived Magnet features and frequent self-nurturance choices are important health influences on nurses' life satisfaction. Greater life satisfaction is known to reduce job dissatisfaction while improving retention. Approaches that incorporate both self-nurturance and workplace Magnet features are suggested to improve the health and retention of experienced nurses.
Catheter Ablation of Ventricular Tachycardia Following Myocardial Infarction Using Three‐Dimensional Electroanatomical Mapping

KAUTZER, J., et al.: Catheter Ablation of Ventricular Tachycardia Following Myocardial Infarction Using Three‐Dimensional Electroanatomical Mapping. One challenge encountered during catheter ablation of postinfarction ventricular tachycardia (VT) is the inducibility of multiple VT morphologies associated with variable hemodynamic instability. The clinical usefulness and safety of a three‐dimensional electroanatomical mapping in guiding radiofrequency (RF) catheter ablation of VT, used in parallel with a multichannel recording system, was studied in 28 men (mean age = 63.8 ± 10.6 years , mean left ventricular ejection fraction = 28%± 9% ). Three‐dimensional voltage maps of the left ventricle were obtained in sinus rhythm with annotation of areas of fractionated or late potentials, zones of slow conduction and/or dense scar with no pacing capture at 10 mA. RF lesions were created either in sinus rhythm or during hemodynamically stable VT within reconstructed critical zones of the circuit. A total of 82 VTs were induced (mean = 2.9 ± 1.0/patient) . Hemodynamically unstable clinical VTs were induced in 5 patients, and clinical or nonclinical unstable VT in 14. Clinical VT was rendered noninducible in 24/28 (85.7%) patients, and monomorphic VT was eliminated in 16/28 (57.1%) patients. The mean procedural time was 258 ± 82 minutes, and fluoroscopic exposure 13.5 ± 8.8 minutes . During a mean follow‐up period of 10.6 ± 6.4 months , catheter ablation was repeated in 6 patients for VT recurrences. No significant complications occurred except for a transient cerebral ischemic attack in one patient. In conclusion, electroanatomical mapping assisted the successful and safe catheter ablation of both mappable and nonmappable VTs in a significant proportion of patients after myocardial infarction. (PACE 2003; 26[Pt. II]:342–347)