Miracle-dz/UniFAR-FTUs huggingface dataset:
“GWM Looking for Sex—SERIOUS ONLY”: The Interplay of Sexual Ad Placement Frequency and Success on the Sexual Health of “Men Seeking Men” on Craigslist

Over the past few years, researchers have begun to explore the use of the personals section on Craigslist.org as it applies to the sexual behaviors and partner accrual of men who have sex with men (MSM). Yet, the exact ramifications of such a free sexual advertisement service on MSM's sexual health and sexual risk-taking behaviors are just being documented. As such, we surveyed 535 men by responding to their sexual ads placed on Craigslist.org to assess their sexual health and sexual health behaviors. Using Self-Efficacy Theory as our foundation, we posited that MSM who placed more ads and reported more success from these ads would also report more negative health behaviors (e.g., lowered condom use) and sexually transmitted diseases. Testing confirmed this hypothesis. This study has two important implications. (1) The behavior of Internet cruising, on its own, insufficiently impacted MSM health. It was the interaction of number of ads (self-efficacy) and the success of those ads (outcome-efficacy) that ultimately contributed to negative health behaviors. (2) MSM may have had different intentions for cruising. The anti-theoretical tendency for some men to continually place high numbers of ads while also reporting very low success suggested that the outcome of merely placing the ads might be sufficiently erotic for some men.
Beneficial Effect of Spironolactone Administration on Ethynylestradiol-Induced Cholestasis in the Rat: Involvement of Up-Regulation of Multidrug Resistance-Associated Protein 2

The effect of spironolactone (SL) administration on 17α-ethynylestradiol (EE)-induced cholestasis was studied, with emphasis on expression and activity of Mrps. Adult male Wistar rats were divided into the following groups: EE (5 mg/kg daily for 5 days, s.c.), SL (200 μmol/kg daily for 3 days, i.p.), EE+SL (same doses, SL administered the last 3 days of EE treatment), and controls. SL prevented the decrease in bile salt-independent fraction of bile flow induced by EE, in association with normalization of biliary excretion of glutathione. Western blot studies indicate that EE decreased the expression of multidrug resistance-associated protein 2 (Mrp2) by 41% and increased that of Mrp3 by 200%, whereas SL only affected Mrp2 expression (+60%) with respect to controls. The EE+SL group showed increased levels of Mrp2 and Mrp3 to the same extent as that registered for the individual treatments. Real-time polymerase chain reaction studies indicated that up-regulation of Mrp2 and Mrp3 by SL and EE, respectively, was at the transcriptional level. To estimate Mrp2 and Mrp3 activities, apical and basolateral excretion of acetaminophen glucuronide (APAP-glu), a common substrate for both transporters, was measured in the recirculating isolated perfused liver model. Biliary/perfusate excretion ratio was decreased in EE (-88%) and increased in SL (+36%) with respect to controls. Coadministration of rats with SL partially prevented (-53%) impairment induced by EE in this ratio. In conclusion, SL administration to EE-induced cholestatic rats counteracted the decrease in bile flow and biliary excretion of glutathione and APAP-glu, a model Mrp substrate, findings associated with up-regulation of Mrp2 expression.
Production and neurotropism of lentivirus vectors pseudotyped with lyssavirus envelope glycoproteins.

We investigated the production efficiency and the gene transfer capacity in the central nervous system of HIV-1-based vectors pseudotyped with either the G protein of the Mokola lyssaviruses (MK-G), a neurotropic virus causing rabies disease, or the vesiculo-stomatitis G protein (VSV-G). Both envelopes induced syncitia in cell cultures. They were incorporated into vector particles and mature virions were observed by electron microscopy. Vector production was two- to sixfold more efficient with VSV-G than with MK-G. For equivalent amounts of physical particles, vector titration was 5- to 25-fold higher with VSV-G than with MK-G pseudotypes on cultured cells, and in vivo gene expression in mouse brain was more intense. Thus, VSV-G pseudotypes were produced more efficiently and were more infectious than MK-G pseudotypes. Tropism for brain cells was analyzed by intrastriatal injections in rats. Both pseudotypes preferentially transduced neurons (70-90% of transduced cells). Retrograde axonal transport was investigated by instilling vector suspensions in the rat nasal cavity. Both pseudotypes were efficiently transported to olfactive neuron bodies. Thus, although coating HIV-1 particles with rabdhovirus envelope glycoproteins enables them to enter neuronal cells efficiently, pseudotyping is not sufficient to confer the powerful neurotropism of lyssaviruses to lentivirus vectors.
The Ciclovía-Recreativa: A mass-recreational program with public health potential.

BACKGROUND The Ciclovía-Recreativa is a free, community-based program in which streets are closed temporarily to motorized transport, allowing access to walkers, runners, rollerbladers, and cyclists only. We assessed existing information about the Ciclovía as a public health strategy and proposed next steps for research and public health practice. METHODS We conducted a systematic search of peer-reviewed and other literature, which was complemented by expert interviews and consultation. RESULTS We reviewed 38 Ciclovías from 11 countries. Most programs (84.2%) take place in urban settings. The programs range from 18-64 events per year (54 + or - 24.6; 52 [mean + or - standard deviation; median]) with events lasting from 2-12 hours (6 + or - 2.4; 6). The length of the streets ranges from 1-121 km (14.6 + or - 22.1; 7), and the estimated number of participants per event ranges from 60-1,000,000 persons (61,203 + or - 186,668; 3810). Seventy-one percent of the programs include physical activity classes and in 89% of the Ciclovías, the streets are connected with parks. CONCLUSIONS Ciclovías have potential for positive public health outcomes, but evidence on their effectiveness is limited. The different stages of new and established programs offer a unique opportunity for transnational studies aimed at assessing their public health impact.
Prevalence, Age Distribution, and Risk Factors of Visual Inspection With Acetic Acid-Positive From 2007 to 2011 in Jakarta

Background Cervical cancer is still the second most frequent cancer among Indonesian women, thus screening program is still critically important to prevent it. Visual inspection with acetic acid (VIA) was introduced as a method which is most suitable with Indonesia’s condition compared with the other screening methods. The Female Cancer Program from Jakarta Regional collaborated with Leiden University in 2007 to 2011 has done cervical cancer screening using VIA method, involving 25,406 women spreading across several primary health centers in Jakarta. By using these data, we found out the prevalence, age distribution, and risk factor of VIA positive in Jakarta as a basis to predict the budget and logistics for the next cervical cancer screening and to do an advocating to the Jakarta’s government. Methods A secondary data analysis was conducted from several areas in Jakarta from 2007 to 2011. VIA test was used as the screening method, and performed by doctors and midwives with technical supervision by gynecologists. Results From 25,406 women, there were 1,192 cases (4.7%) of VIA test positive. The risk factors that can significantly influence the result of VIA positive were number of marriage, parity, smoking habits, and the use of hormonal contraception with OR 1.51, 1.85, 1.95, and 0.68, respectively. Conclusions Prevalence of VIA test-positive is 4.7% in Jakarta population. The findings of precancerous lesions and cervical cancers are not only between thirty and fifty years old, but also below the thirty years old and after fifty years old. We suggest that VIA test should be performed to all reproductive age and elder women who are not screened yet.
Object play in infants with autism spectrum disorder: A longitudinal retrospective video analysis

Background and aims Early play behaviors may provide important information regarding later-diagnosed developmental delays. Play behaviors of young children with autism spectrum disorder are restricted in diversity, frequency, and complexity. Most autism spectrum disorder research focuses on play in children over 18 months of age. This study examined three groups of infants (later diagnosed with autism spectrum disorder, later diagnosed with other developmental disorders, and typically developing) with the aims of: (1) describing the play behaviors of the three groups of infants at two time points (9–12 months and 15–18 months); (2) examining group differences in four hierarchical levels of play at both time points; (3) comparing groups with respect to the highest level of play achieved; and (4) determining if the highest level of play achieved by infants with autism spectrum disorder and other developmental delays correlated with later developmental outcomes. Methods The current study used longitudinal retrospective video analysis to examine object play behaviors of the three groups of infants (total n = 92) at two time points (time 1: 9–12 months of age, and time 2: 15–18 months of age). Coding of play behaviors was based on existing literature and distribution of data from the current study. Developmental outcomes examined were measured using the Vineland Adaptive Behavior Scales, Childhood Autism Rating Scale, and a non-verbal developmental quotient calculated using visual reception scores from the Mullen Scales for Early Learning. Results Results indicate group differences in play, with infants later diagnosed with autism spectrum disorder showing significantly less sophisticated play than those with typical development. In addition, modest but significant correlations were found between highest level of play achieved at time 1 (9–12 months) and time 2 (15–18 months) and later outcomes for the autism spectrum disorder group. Conclusions and implications Results suggest that examination of infant play behaviors is important for early screening and intervention planning to potentially mitigate effects on later developmental outcomes.
The distribution of handedness in chimpanzees: Estimating right shift in Hopkins' sample

The right shift (RS) theory of handedness and cerebral dominance suggests that hand preference depends on an underlying continuous normal distribution of asymmetry for hand skill. The distribution in humans is displaced towards the right, in comparison with the unbiased distribution expected for most nonhuman species. Reports that chimpanzees are more often right- than left-handed raise the question whether they also have a distribution of asymmetry shifted to the right. This paper shows how to estimate extent of RS from classifications of hand preference as left, mixed, and right. Whereas the human distribution is shifted by about 1.0 z, that of chimpanzees in the sample of Hopkins, Cantalupo, Freeman, Russell, Kachin, and Nelson (2005) is shifted by about 0.32 z.
Enhancing Password Security through Interactive Fear Appeals: A Web-Based Field Experiment

Passwords remain the dominant authentication mechanism for information security. Unfortunately, research has shown that most passwords are highly insecure. Given the risks of using weak passwords, there is a need to effectively motivate users to select strong passwords. In this study we examine the influence of interactivity, as well as static and interactive fear appeals, on motivating users to increase the strength of their passwords. We developed a field experiment involving the account registration process of a website in use in which we observed the strength of passwords chosen by users. Data were collected from 354 users in 65 countries. We found that while the interactive password strength meter and static fear appeal treatments were not effective, the interactive fear appeal treatment resulted in significantly stronger passwords. Our findings suggest that interactive fear appeals are a promising means of encouraging a range of secure behaviors in end users.
Lingering neighbourhood effects: A framework to account for residential histories and temporal dynamics

The large and growing body of neighbourhood effect studies has almost exclusively neglected individuals’ particular residential histories. Yet, former residential neighbourhoods are likely to have lingering effects beyond those of the current one and are dependent on exposure times and number of moves. This paper tests to what extent this blind spot induced a misestimation of neighbourhood effects for individuals with differential residential histories. Ultimately, we develop a methodological framework for studying the temporal dynamics of neighbourhood effects, capable of dealing with residential histories (moving behaviour, the passage of time and temporal exposure to different neighbourhoods). We apply cross-classified multi-level models (residents nested in current and former neighbourhoods) to analyse longitudinal individual-level population data from Dutch Statistics, covering fine-grained measures of residential histories. Our systematic comparison to conventional models reveals the necessity of including a temporal dimension: our models reveal an overestimation of the effect of the current neighbourhood by 16–30%, and an underestimation of the total body of neighbourhood effects by at least 13–24%. Our results show that neighbourhood effects are lingering, long-lasting and structural and also cannot be confined to a single point in time.
The Healthy Moms Study: the efficacy of brief alcohol intervention in postpartum women.

BACKGROUND The prevention and treatment of alcohol use disorders among women of reproductive age have been well described. However, there is limited information on women specifically during the postpartum period. This period in a woman's life is a time of transition and it provides an ideal opportunity for primary care providers to intervene. PURPOSE The goal of this report was to present the results of a brief alcohol intervention conducted in 34 obstetrical practices with women seeking routine postpartum care. METHODS A randomized clinical trial was conducted from 2002 to 2005 in a diverse sample of women located in 15 Wisconsin counties. This report presents 6-month follow-up data. RESULTS A total of 8,706 women were screened for high-risk alcohol use during routine postpartum care with 997 (12%) of these women testing positive for at-risk drinking. A total of 235 women met inclusion criteria and were randomized to either "usual care" or "brief intervention. " The 4-session intervention was delivered by outpatient obstetrical nurses and research staff. The mean age of the women in the sample was 28, 19.3% were from minority groups, 60.8% were married, 53.2% reported current tobacco use, and 17.9% had used marijuana in the previous 30 days. At the 6 month follow-up appointment, there were significant reductions in mean number of total drinks in the previous 28 days (p < 0.013), number of drinking days (p < 0.024) and heavy drinking days (p < 0.019). In addition to a statistical difference between groups, there was a 19% difference in the mean number of drinks and number of drinking days, and a 36% difference in the number of heavy drinking days in favor of the intervention group. CONCLUSION The findings of the Healthy Moms Trial support the implementation of brief alcohol intervention during the postpartum period.
Bank Deregulation, Consolidation and Stability: M&A Centric Evidence on U.S.

We analyze whether and how bank deregulation relates to the M&A centric consolidation of U.S. banking industry. Using difference-in-difference approach on M&A activity of banks over a time span of 1990-2009, we find a positive and statistically significant effect of deregulation on bank consolidation in overall and functionally diverse M&A terms. However, geographically diverse M&A activity remains largely unaffected by bank deregulation. Importantly, these results are predominantly observed in a pre-crisis period analysis. We also confirm negative implications of deregulation and consolidation over the bank stability, thus supporting the popular narrative that holds bank deregulation partly responsible for the 2007 financial calamity.
Transcriptional Coactivator PC4 Stimulates Promoter Escape and Facilitates Transcriptional Synergy by GAL4-VP16

ABSTRACT Positive cofactor 4 (PC4) is a coactivator that strongly augments transcription by various activators, presumably by facilitating the assembly of the preinitiation complex (PIC). However, our previous observation of stimulation of promoter escape in GAL4-VP16-dependent transcription in the presence of PC4 suggested a possible role for PC4 in this step. Here, we performed quantitative analyses of the stimulatory effects of PC4 on initiation, promoter escape, and elongation in GAL4-VP16-dependent transcription and found that PC4 possesses the ability to stimulate promoter escape in response to GAL4-VP16 in addition to its previously demonstrated effect on PIC assembly. This stimulatory effect of PC4 on promoter escape required TFIIA and the TATA box binding protein-associated factor subunits of TFIID. Furthermore, PC4 displayed physical interactions with both TFIIH and GAL4-VP16 through its coactivator domain, and these interactions were regulated distinctly by PC4 phosphorylation. Finally, GAL4-VP16 and PC4 stimulated both initiation and promoter escape to similar extents on the promoters with three and five GAL4 sites; however, they stimulated promoter escape preferentially on the promoter with a single GAL4 site. These results provide insight into the mechanism by which PC4 permits multiply bound GAL4-VP16 to attain synergy to achieve robust transcriptional activation.
Single window stream aggregation using reconfigurable hardware

High throughput and low latency stream aggregation — and stream processing in general — is critical for many emerging applications that analyze massive volumes of continuously produced data on-the-fly, to make real time decisions. In many cases, high speed stream aggregation can be achieved incrementally by computing partial results for multiple windows. However, for particular problems, storing all incoming raw data to a single window before processing is more efficient or even the only option. This paper presents the first FPGA-based single window stream aggregation design. Using Maxeler's dataflow engines (DFEs), up to 8 million tuples-per-second can be processed (1.1 Gbps) offering 1–2 orders of magnitude higher throughput than a state-of-the-art stream processing software system. DFEs have a direct feed of incoming data from the network as well as direct access to off-chip DRAM processing a tuple in less than 4 μsec, 4 orders of magnitude lower latency than software. The proposed approach is able to support challenging queries required in realistic stream processing problems (e.g. holistic functions). Our design offers aggregation for up to 1 million concurrently active keys and handles large windows storing up to 6144 values (24 KB) per key.
Timing of Surgical Repair After Bile Duct Injury Impacts Postoperative Complications but Not Anastomotic Patency

Objective: Our goal was to determine the optimal timing for repair of bile duct injuries sustained during cholecystectomy. Background: Bile duct injury during cholecystectomy is a serious complication that often requires surgical repair. There is heterogeneity in the literature regarding the optimal timing of surgical repair, and it remains unclear to what extent timing determines postoperative morbidity and long-term anastomotic function. Methods: A single institution prospective database was queried for all E1 to E4 injuries from 1989 to 2014 using a standardized tabular reporting format. Timing was stratified into 3 groups [early (<7 days), intermediate (8 days until 6 weeks), and late (>6 weeks) after injury]. Analysis was stratified between those who had a previous bile duct repair or not, including postoperative complications and anastomotic failure as outcome variables in 2 separate multivariate logistic regression models. Results: There were 614 patients included in the study. The mean age was 41 years (range, 15–85 yrs), and the majority were female (80%). The mean follow-up time was 40.5 months. Side-to-side hepaticojejunostomy was performed in 94% of repairs. Intermediate repair was associated with a higher risk of postoperative complications [odd ratio = 3.7, 95% confidence interval (1.3–10.2), P = 0.01] when compared with early and late in those with a previous repair attempt. Sepsis control and avoidance of biliary stents were protective factors against anastomotic failure. Conclusions: Adequate sepsis control and delayed repair of biliary injuries should be considered for patients presenting between 8 days and 6 weeks after injury to prevent complications, if a previous bile duct repair was attempted.
Food restriction during organogenesis in rabbits: effects on reproduction and the offspring.

To assess the effects of markedly restricted food intake versus ad libitum feeding or a slightly restricted feeding regimen during the period of organogenesis we fed groups of 16-18 pregnant rabbits Purina Certified High Fiber Chow ad libitum, 150 g/day, 75 g/day, or 15 g/day on Gestation Days 6 to 18 inclusive. Prior to and after organogenesis the animals were provided food ad libitum (ad lib). Clinical observations, body weights, and food and water consumption were recorded daily. On Gestation Day 30 each doe was euthanatized and necropsied, and maternal and fetal data were collected. Each fetus was examined for external, visceral, and skeletal variations and malformations. Ossification parameters were also evaluated. Statistical analyses were conducted in two ways, first comparing the restricted groups to the ad lib group and second comparing the 15 and 75 g/day groups to the 150 g/day group. During Days 6-18, the 15 and 75 g/day groups had significantly decreased weight gain (actual weight loss), compared to the groups fed 150 g/day or ad lib. Water consumption was also significantly decreased in the 15 g/day group during this period, compared to the ad lib group. When food was provided ad lib on Days 19-30 to the restricted groups, weight gain was significantly higher in the 15 and 75 g/day groups than the group previously given 150 g/day and the ad lib group. There were no differences in water consumption during that period. Abortion occurred in three 15 g/day animals. (ABSTRACT TRUNCATED AT 250 WORDS)