Miracle-dz/UniFAR-FTUs huggingface dataset:
Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death‐dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension

Our understanding of the pathobiology of severe pulmonary hypertension, usually a fatal disease, has been hampered by the lack of information of its natural history. We have demonstrated that, in human severe pulmonary hypertension, the precapillary pulmonary arteries show occlusion by proliferated endothelial cells. Vascular endothelial growth factor (VEGF) and its receptor 2 (VEGFR‐2) are involved in proper maintenance, differentiation, and function of endothelial cells. We demonstrate here that VEGFR‐2 blockade with SU5416 in combination with chronic hypobaric hypoxia causes severe pulmonary hypertension associated with precapillary arterial occlusion by proliferating endothelial cells. Prior to and concomitant with the development of severe pulmonary hypertension, lungs of chronically hypoxic SU5416‐treated rats show significant pulmonary endothelial cell death, as demonstrated by activated caspase 3 immunostaining and TUNEL. The broad caspase inhibitor Z‐Asp‐CH2DCB prevents the development of intravascular pulmonary endothelial cell growth and severe pulmonary hypertension caused by the combination of SU5416 and chronic hypoxia. —Taraseviciene‐Stewart, L. , Kasahara, Y. , Alger, L. , Hirth, P., McMahon, G. , Waltenberger, J., Voelkel, N. F. , Tuder, R. M. Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death‐dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension. FASEB J. 15, 427‐438 (2001)
Multi-sentiment Modeling with Scalable Systematic Labeled Data Generation via Word2Vec Clustering

Social networks are now a primary source for news and opinions on topics ranging from sports to politics. Analyzing opinions with an associated sentiment is crucial to the success of any campaign (product, marketing, or political). However, there are two significant challenges that need to be overcome. First, social networks produce large volumes of data at high velocities. Using traditional (semi-) manual methods to gather training data is, therefore, impractical and expensive. Second, humans express more than two emotions, therefore, the typical binary good/bad or positive/negative classifiers are no longer sufficient to address the complex needs of the social marketing domain. This paper introduces a hugely scalable approach to gathering training data by using emojis as proxy for user sentiments. This paper also introduces a systematic Word2Vec based clustering method to generate emoji clusters that arguably represent different human emotions (multi-sentiment). Finally, this paper also introduces a threshold-based formulation to predicting one or two class labels (multi-label) for a given document. Our scalable multi-sentiment multi-label model produces a cross-validation accuracy of 71.55% (± 0.22%). To compare against other models in the literature, we also trained a binary (positive vs. negative) classifier. It produces a cross-validation accuracy of 84.95% (± 0.17%), which is arguably better than several results reported in literature thus far.
Do Environmental Taxes Pay Off? The Impact of Energy and Transport Taxes on CO2 Emissions in Transition Economies

Abstract In this paper we investigate the impact of environmental taxes on CO2 emissions in the context of emerging market economies. An attempt has been made to identify what role environmental policy and specific tax policy measures play in understanding the relationship between economic development and environmental degradation. The empirical analysis covers ten Central and Eastern European countries in the period from 1995 to 2015. The latest data on environmental taxes are available only from 1995. We contribute to recent literature in two respects. First, we study this relationship within a dynamic framework in which we take into account the issues of serial correlation and endogeneity in the regressors due to the cointegration relationship. Specifically, we rely on the fully-modified least squares (FM-OLS) estimation technique to model the long-term relationship between income and carbon-dioxide emissions. Second, this paper advances our understanding on the effectiveness of tax policy measures in curbing CO2 emissions, on which we have scarce empirical evidence. The results of this analysis provide rather strong evidence in support of an inverted U-shaped relationship between economic growth and the environment. However, environmental taxes do not seem to be effective in modifying the behaviour of economic agents and in protecting the environment. The results are robust to different models.
Interobserver agreement in the application of levels of evidence to scientific papers in the American volume of the Journal of Bone and Joint Surgery.

BACKGROUND Since January 2003, all clinical scientific articles published in the American volume of The Journal of Bone and Joint Surgery (JBJS-A) have included a level-of-evidence rating. The aim of the current study was to evaluate the interobserver agreement among reviewers, with varying levels of epidemiology training, in categorizing the levels of evidence of these clinical studies. METHODS Fifty-one consecutive clinical papers published in the American volume of JBJS were identified by a computerized search of the table of contents from January 2003 through June 2003. Each paper was blinded so that only the title, abstract (without the level of evidence designated), and methods section were provided to the reviewers. The papers were coded and were randomly organized in a binder. Six surgeons graded each blinded paper for (1) the type of study (therapeutic, prognostic, diagnostic test, or economic or decision analysis), (2) the level of evidence (on a scale of I through V), and (3) the subcategory within the particular level of evidence. Three surgeons were members of JBJS American Editorial Board, two surgeons were reviewers for JBJS-A, and one surgeon was an active researcher not formally associated with JBJS-A. The reviewers did not receive any formal training in the application of the classification system, but each was provided with a detailed description of the classification system used by JBJS-A. Intraclass correlation coefficients with 95% confidence intervals were determined for the reviewers' agreement regarding the type of study, level of evidence, and subcategory within the level of evidence. RESULTS The majority (69%) of the fifty-one included articles were studies of therapy, and 57% of the studies constituted Level-IV evidence. The intraclass correlation coefficients for the agreement among all reviewers with regard to the study type, level of evidence, and subcategory within the level of evidence ranged from 0.61 to 0.75. Reviewers trained in epidemiology demonstrated greater agreement (range in intraclass correlation coefficients, 0.99 to 1.0), across all aspects of the classification system, than did reviewers who were not trained in epidemiology (range in intraclass correlation coefficients, 0.60 to 0.75). CONCLUSIONS These findings suggest that epidemiology and non-epidemiology-trained reviewers can apply the levels-of-evidence guide to published studies with acceptable interobserver agreement. The validity of this system remains a question for future research.
HEADS-UP SURGERY FOR VITREORETINAL PROCEDURES: An Experimental and Clinical Study

Purpose: To investigate the feasibility of performing vitrectomies while viewing a three-dimensional image on a large display in a heads-up position. Methods: Twenty volunteers were compared performing meticulous tasks using the heads-up and the traditional method. Some optical parameters, resolution and depth of field, were measured, and the possibilities of digital image processing were investigated. In addition, routine use of the heads-up method for >400 vitrectomies over 8 months was retrospectively analyzed. Results: Of note, 91.7% of the volunteers preferred the ergonomics of the heads-up technique. The two methods were judged to be similar regarding speed and ease of microscopic manipulations and sharpness of image. Significantly fewer mistakes were made with the heads-up method. The measured resolution of the eyepieces was approximately twice that of the three-dimensional display, whereas depth of the field was about equal. Electronic amplification of the camera's signal resulted in increased image brightness, allowing use of reduced endoillumination levels. In clinical routine, better ergonomics, digital image processing, and use of a large display are found to be major advantages. Conclusion: The heads-up method is well suited for vitreoretinal surgery. With further technical improvements, the procedure should soon find widespread use.
Immunohistochemical Characterization of Cyclin E and p27KIP1 Expression in Early Hydatidiform Moles

Summary:The aim of this study is to evaluate whether the expression of p27KIP1 (p27) and cyclin E (cE) is related to the development of hydatidiform moles and whether their expressions are associated with prognosis in these lesions. Ten diploid voluntary artificial abortions (ABs), 20 diploid hydropic abortions (HAs), 20 triploid partial moles (PMs), and 44 diploid complete moles (CMs) (including 4 with persistent disease), all of which were in the first trimester, were evaluated by immunohistochemistry of formalin-fixed tissues using monoclonal antibodies against p27 and cE protein. DNA ploidy in all cases was analyzed by flow cytometry. In ABs, nuclear cE was expressed at low (1+) to moderate (2+) levels in cytotrophoblast (CT), intermediate trophoblast (IT) and occasionally in syncytiotrophoblast (ST). In all CMs, cE-positive nuclei of CT were observed at high levels (3+), and (1+) to (2+) levels in clusters of IT. On the other hand, all HAs and PMs showed cE levels comparable to those observed in ABs. There was a significant difference in cyclin E expression in CT between CMs and non CMs, but there was no significant difference of cE levels between CMs with and without persistent disease. In 3 of 10 ABs, nuclear p27 was expressed at (1+) levels in ST. Similar expression was observed in 27 (including 2 invasive lesions) of 44 CMs, 10 of 20 PMs, and 8 of 20 HAs. CT and IT were rarely positive (1+) for p27 in the cases examined. Decidual stromal cells provided a reliable positive internal control for p27 expression. These findings support the hypothesis that trophoblast proliferation is related to the balance between the positive cell cycle factors, such as cE, and the negative cell cycle inhibitors, such as p27. The overexpression of cE in the trophoblastic elements suggests that cE protein expression may be dysregulated in early CMs. Neither cE nor p27 expression is a prognostic indicator in CMs.
Comparison of Canadian firefighters and healthy controls based on submaximal fitness testing and strength considering age and gender

Introduction. Few studies have addressed whether firefighters are fitter than the general population and possess sufficient levels of aerobic capacity and muscle strength to perform on-duty tasks in a safe and efficient manner, considering age and gender. We aimed to evaluate the fitness levels of Hamilton firefighters, and to determine the effects of age and gender. Methods. In total, 89 participants were recruited. The modified Canadian aerobic fitness test was used to determine participants’ estimated maximal oxygen consumption (VO2max) levels. For upper and lower body strength levels, a calibrated J-Tech hand-held dynamometer and a National Institute for Occupational Safety and Health (NIOSH) lifting device was used respectively. Results. Firefighters’ mean (SD) VO2max level was 40.30 ± 6.25 ml·kg−1·min−1. Age proved to have a statistically significant impact on VO2max (p < 0.001). Gender displayed statistically significant effects on strength levels. Firefighters’ age was the only statistically significant independent variable, and accounted for 61.00% of the variance in firefighters’ aerobic capacity levels. Conclusions. Firefighters possessed somewhat similar aerobic capacities but much higher levels of body strength when compared with the general population. With age, firefighters’ aerobic capacities decreased; however, their upper and lower body strength levels remained the same.
An SIS Mixer With  $2hf/k$ DSB Noise Temperature at 163–211 GHz Band

We present the design and the performance of a fixed-tuned, all niobium (Nb) Superconductor-Insulator-Superconductor (SIS) mixer covering RF frequencies from 163 to 211 GHz with 4-8 GHz IF bandwidth. The mixer uses two Nb/Al-AlOx/Nb junctions of size 3 μm2 each with the RnA product of 30 Ω·μm 2, in a twin junction configuration. An local oscillator (LO) directional coupler made of superconducting lines with slots in the ground plane is integrated on the SIS mixer chip. The isolated port of the LO coupler is terminated using a wide-band resistive load with a sheet resistance of 12 Ω/□. The SIS tuning circuitry is optimized to achieve best power match between the twin junctions and the embedding circuitry. The measurement of the double sideband mixer noise at 171 GHz shows that the receiver noise temperature is approximately 17 K, which is just 2 hf/k. The estimated noise contribution from the RF loss and the IF chain at 176 GHz LO frequency is 8 K and 7.5 K respectively, resulting in a SIS mixer noise of hf/2k . The mixer noise performance across the entire RF band varies between 19 to 25 K. This is to our knowledge the best reported noise temperature at these frequencies till now.
The effect of various topical antibiotic and antibacterial agents on the middle and inner ear of the guinea‐pig

The topical application of antibiotics and anti‐inflammatory agents is used to reduce inflammation of the middle ear mucosa and irradicate infection. Many of the antibiotic and anti‐inflammatory preparations so used contain compounds known to be or are potentially ototoxic. Eighteen antibiotic, antibacterial, antifungal and anti‐inflammatory compounds and four commonly used solvents were screened for the absence of ototoxicity and inflammation to the middle ear mucosa. All compounds were injected intra‐tympanically and sensory hair cell loss recorded graphically. Inflammation of the middle ear mucosa was assessed macroscopically. Of the 18 compounds only three, penicillin, carbenicillin and nystatin were free of hair cell toxicity and inflammatory effects on the middle ear mucosa. Only one of the commonly used solvents was free of side effects.
Diagnostic and Subdiagnostic Accumulation of Mast Cells in the Bone Marrow of Patients with Anaphylaxis: Monoclonal Mast Cell Activation Syndrome

Background: Patients with mastocytosis may suffer from severe hypotension after wasp or bee stings. In these patients, no specific IgE is detectable, but they usually have skin lesions and an elevated serum tryptase level. Methods: We report on 6 patients who were referred to our department because of severe hypotension following bee or wasp stings without cutaneous lesions. Results: In 3 patients, the baseline serum tryptase level was elevated (26, 36, and 67 ng/ml, respectively), and investigation of their bone marrow revealed systemic mastocytosis (SM). In the remaining 3 patients, serum tryptase levels were <20 ng/ml, and bone marrow histology and tryptase immunohistochemistry did not reveal diagnostic mast cell infiltrates. However, in 1 patient, three minor SM criteria were demonstrable leading to the diagnosis SM, and in the 2nd patient, two minor SM criteria, including an aberrant mast cell phenotype, were found. In the 3rd patient, no minor SM criteria were detected. Conclusions: All patients with unexplained hypotension after hymenoptera stings should undergo a thorough investigation for major and minor SM criteria regardless of the tryptase level or presence of skin lesions, in order to diagnose or exclude SM or a related subdiagnostic condition (1 or 2 minor SM criteria) tentatively termed monoclonal mast cell activation syndrome.
Dancing with wolves: how value creation and value capture dynamics affect complementor participation in industry platforms

ABSTRACT Industry platforms shape the interactions among participating firms, especially between the platform owner and its complementors. However, little research has examined how such dynamics would influence the initial participation by complementors. Based on the coopetition perspective, we develop hypotheses about the relationship between platform owner’s value appropriation potential and complementor participation, at platform initiation. Using a comprehensive dataset of open source software (OSS) platform initiations, this study empirically examines how the resource profiles of platform owner firms may affect complementor participation in the platform. We find that when the platform owner has higher percentage of sales from complementary market segments, the number of complementors for the platform is lower. Furthermore, the platform owner’s sales growth positively moderates this relationship. The findings shed new lights on how the value creation and value appropriation dynamics between the platform owner and its complementors may shape the outcome of industry platform launching.
Expression of mitochondria-related genes in lymphoblastoid cells from patients with bipolar disorder.

OBJECTIVES Several studies have suggested mitochondrial abnormality in bipolar disorder. We reported the association of mitochondrial complex I subunit gene, NDUFV2 at 18p11, with bipolar disorder. A decrease in the mRNA expression of this gene was found in patients with bipolar disorder compared with controls. However, it was unclear whether only the NDUFV2 gene exhibited the decreased expression level in bipolar disorder. The aim of this study was to clarify the association of other nuclear-encoded complex I subunit genes and mitochondria-related genes with bipolar disorder. METHODS We quantified the mRNA expression level of five nuclear-encoded mitochondrial complex I subunit genes located at the chromosomal regions linked with bipolar disorder other than NDUFV2, three complex IV subunit genes, and four mitochondrial transcription-related genes using a real-time quantitative reverse transcription polymerase chain reaction method in the lymphoblastoid cell lines from 21 patients with bipolar disorder and 11 controls. RESULTS Decreased mRNA expression in patients with bipolar I disorder compared with control subjects was found in most of the complex I subunit genes. In addition, decreased expression levels of these genes correlated with that of NDUFV2. No statistically significant alterations of mRNA expression levels were found between bipolar patients and controls among two of three complex IV subunit genes and all transcription-related genes. CONCLUSIONS Our study suggests that the decreased expression of NDUFV2 has a considerable effect on other subunit genes in the mitochondrial respiratory chain and presents further evidence of the biological significance of NDUFV2 in bipolar disorder.
Outcome Measures in Neurological Physical Therapy Practice: Part I. Making Sound Decisions

Standardized outcome measures (OMs) are a vital part of evidence-based practice. Despite the recognition of the importance of OMs, recent evidence suggests that the use of OMs in clinical practice is limited. Selecting the most appropriate OM enhances clinical practice by (1) identifying and quantifying body function and structure limitations; (2) formulating the evaluation, diagnosis, and prognosis; (3) informing the plan of care; and (4) helping to evaluate the success of physical therapy interventions. This article (Part I) is the first of a 2-part series on the process of selecting OMs in neurological clinical practice. We introduce a decision-making framework to guide the selection of OMs and discuss 6 main factors—what to measure, the purpose of the measure, the type of measure, patient and clinic factors, psychometric factors, and feasibility—that should be considered when selecting OMs for clinical use. The framework will then be applied to a patient case in Part II of the series (see the article “Outcome Measures in Neurological Physical Therapy Practice: Part II. A Patient-Centered Process” in this issue).
Investigation of the Profile of Hearing Aid Performance in Experienced Hearing Aid Users

Objective: A shortened version of the 66‐item Profile of Hearing Aid Performance (PHAP), consisting of the 24 items from the Abbreviated Profile of Hearing Aid Benefit, was evaluated as an alternative to the full PHAP questionnaire as a measure of hearing aid performance. Objectives were to: 1) statistically determine factors underlying Abbreviated PHAP (APHAP) scores; 2) recommend modifications to the questionnaire, if indicated by the factor analysis; 3) compare scores for the PHAP and APHAP; and 4) determine the suitability of the abbreviated questionnaire for New Zealand hearing aid users. The relationship between hearing aid performance and subjective variables and other measures of hearing aid success also was investigated. Design: PHAP data, hearing aid satisfaction ratings, and reported daily hearing aid use were obtained from experienced adult hearing aid users. Factor analysis was carried out for the 24 APHAP items, and two items were excluded because of low factor loadings. After this modification, APHAP and PHAP scores were compared. Pearson's correlation values were determined for PHAP and APHAP data and degree of hearing loss, hearing aid satisfaction, and hours of hearing aid use. Results: APHAP hearing aid performance was better described as three factors rather than four subscales. PHAP and APHAP results were consistent with previous studies and showed that hearing aid performance was best for easy listening situations and poorest for noisy and/or reverberant conditions. Similar trends were seen for PHAP and APHAP data. APHAP scores were correlated with hours of hearing aid use and overall hearing aid satisfaction. Conclusions: A shortened, 22‐item APHAP is a preferred alternative to the full PHAP, producing data representing several dimensions of hearing aid performance. Modified APHAP scores can be used together with overall satisfaction and estimates of daily hearing aid use to measure success with hearing aids.
Perception of very small visual stimuli in the fovea: normative data for the Rarebit Foveal Test

Background: Conventional visual tests are not sensitive enough to detect low degree neural damage, as 6/6 (1.0) visual acuity can be upheld with less than two‐thirds of the normal number of optic nerve axons. The aim of the current study was to evaluate the physiologic properties of a new computerised test, the Rarebit Fovea Test (RFT), using very small stimuli, by quantifying the effect of age and binocular summation in relation to stimulus luminance.