Miracle-dz/UniFAR-FTUs huggingface dataset:
Multi-Domain Neural Machine Translation through Unsupervised Adaptation

We investigate the application of Neural Machine Translation (NMT) under the following three conditions posed by real-world application scenarios. First, we operate with an input stream of sentences coming from many different domains and with no predeﬁned order. Second, the sentences are presented without domain information. Third, the input stream should be processed by a single generic NMT model. To tackle the weaknesses of current NMT technology in this unsupervised multi-domain setting, we explore an ef-ﬁcient instance-based adaptation method that, by exploiting the similarity between the training instances and each test sentence, dynamically sets the hyperparameters of the learning algorithm and updates the generic model on-the-ﬂy. The results of our experiments with multi-domain data show that local adaptation outperforms not only the original generic NMT system, but also a strong phrase-based system and even single-domain NMT models speciﬁ-cally optimized on each domain and applicable only by violating two of our afore-mentioned assumptions.
Addressing Temporal Aspects in User Modelling

Early studies about user modeling already noted that user models need to continuously adapt, as new information about the user becomes available, keeping the user model updated. Although temporal aspects are inherent characteristics of user modeling, so far, they were not specifically dealt with. Therefore, the proposed research will suggest an abstract, generic framework to deal with temporal aspects of user modeling while providing guidelines based on domains characteristics for handling temporal aspects in User Modelling.
Resources That May Matter: The Impact of Local Health Department Expenditures on Health Status

Objectives. This study examines the association between changes in local health department (LHD) expenditures, aggregated to the state level, and changes in state-level measures of health, from 1993 to 2005. The literature on the impact of LHD resources on health status has been limited by cross-sectional designs. With repeated surveys of LHDs, it is now possible to use longitudinal designs to explore the association between LHD inputs and outcomes. Methods. This was a retrospective cohort study. We used a fixed-effects regression model to assess the association between LHD expenditures, aggregated to the state level, and seven separate health measures. We derived LHD expenditure data from the National Association of County and City Health Officials' surveys of LHDs in 1993, 1997, and 2005. We obtained secondary data on seven health measures—smoking and obesity prevalence, infectious disease morbidity, infant mortality, deaths due to cardiovascular disease and cancer, and overall premature death—through the America's Health Rankings® reports, 1990–2008. Usable data were available for 1,470 LHDs, representing 37 states. Results. An increase in LHD expenditures, aggregated to the state level, was associated with a statistically significant decline in state-level infectious disease morbidity (t= −3.28, p=0.002) and in years of potential life lost (YPLL) (t= −2.73, p=0.008). For every $10 increase in aggregated LHD expenditures per capita, infectious disease morbidity decreased by 7.4%, and YPLL decreased by 1.5%. Conclusion. LHD resources are associated with improvements in preventable causes of morbidity and mortality.
Peripheral arterial disease: comparison of color duplex US and contrast-enhanced MR angiography for diagnosis.

PURPOSE To prospectively compare the diagnostic accuracies of color duplex ultrasonography (US) and contrast material-enhanced magnetic resonance (MR) angiography and to assess interobserver agreement regarding contrast-enhanced MR angiographic findings in patients suspected of having peripheral arterial disease (PAD). MATERIALS AND METHODS The institutional review board approved the study, and all patients provided signed informed consent. Two hundred ninety-five patients referred for diagnostic and preinterventional work-up of PAD with duplex US also underwent gadolinium-enhanced MR angiography. Data sets were reviewed for presence or absence of 50% or greater luminal reduction, which indicated hemodynamically significant stenosis, and to determine interobserver agreement. At duplex US, a peak systolic velocity ratio of 2.5 or greater indicated significant stenosis. Primary outcome measures were differences between duplex US and contrast-enhanced MR angiography in sensitivity and specificity for detection of significant stenosis, as assessed with the McNemar test, and interobserver agreement between the two contrast-enhanced MR angiogram readings, expressed as quadratic weighted kappa values. Intraarterial digital subtraction angiography (DSA) was the reference standard. RESULTS Two hundred forty-nine patients had at least one hemodynamically significant stenotic lesion at contrast-enhanced MR angiography, duplex US, or both examinations. One hundred fifty-two patients underwent intraarterial DSA. The quadratic weighted kappa for agreement regarding the presence of 50% or greater stenosis at contrast-enhanced MR angiography was 0.89 (95% confidence interval [CI]: 0.87, 0.91). Sensitivity of duplex US was 76% (95% CI: 69%, 82%); specificity, 93% (95% CI: 91%, 95%); and accuracy, 89%. Sensitivity and specificity of contrast-enhanced MR angiography were 84% (95% CI: 78%, 89%) and 97% (95% CI: 95%, 98%), respectively; accuracy was 94%. Sensitivity (P = .002) and specificity (P = .03) of contrast-enhanced MR angiography were significantly higher. CONCLUSION Results of this prospective comparison between contrast-enhanced MR angiography and duplex US provide evidence that contrast-enhanced MR angiography is more sensitive and specific for diagnosis and preinterventional work-up of PAD.
[Expression and significance of PTEN in nasopharyngeal carcinoma].

OBJECTIVE To investigate the expression of tumor suppressor gene PTEN in nasopharyngeal carcinomas and the relationship between PTEN and the progression of nasopharyngeal cancer. METHOD The SABC immunohistochemistry method was employed to detect the expression of PTEN in paraffin-embedded nasopharyngeal carcinoma tissues. The relationship between the geneexpression and clinicopathological features was analyzed. RESULT Loss of PTEN expression in normal cases (13.3%) was lower than that in nasopharyngeal carcinoma cases (47.8%). Of nasopharyngeal cancer cases, loss of PTEN expression in squama cell nasopharyngeal (58.1%) was higher than that in others tissue type (30.8%); loss of PTEN expression in squama cell nasopharyngeal had correlation with pathological stage, which increased gradually from poorly differentiated to well differentiated squama cell nasopharyngeal; loss of PTEN expression of clinical III-IV stage (78.1%) was higher than that of clinical I-II stage (21.6%). CONCLUSION It is presumed that PTEN gene deletion may be involved in carcinogenesis and progression of nasopharyngeal carcinoma, and relates to the tissue type, the pathological grade and clinical stage.
Functional Identification of Two Novel Genes from Pseudomonas sp. Strain HZN6 Involved in the Catabolism of Nicotine

ABSTRACT Nicotine is a natural alkaloid produced by tobacco plants, and the mechanisms of its catabolism by microorganisms are diverse. In the present study, we reported the mutation, cloning, and identification of two novel genes involved in nicotine degradation from the newly isolated Pseudomonas sp. strain HZN6. Transposon mutagenesis identified a HZN6 mutant in which the nicotine-degrading pathway was blocked at pseudooxynicotine. A 3,874-bp DNA fragment flanking the transposon insertion site was obtained through self-formed adaptor PCR. Two open reading frames (designated pao and sap) were analyzed, and the deduced amino acid sequences shared 29% identity with 6-hydroxy-l-nicotine oxidase from Arthrobacter nicotinovorans and 49% identity with an aldehyde dehydrogenase from Bartonella henselae. Both pao and sap were cloned and functionally expressed in recombinant Escherichia coli BL21. The pao gene encoded a novel pseudooxynicotine amine oxidase with noncovalently bound flavin adenine dinucleotide (FAD) and exhibited substrate specificity removing the methylamine from pseudooxynicotine with the formation of 3-succinoylsemialdehyde-pyridine and hydrogen dioxide. The sap gene encoded a NADP+-dependent 3-succinoylsemialdehyde-pyridine dehydrogenase that catalyzed the dehydrogenation of 3-succinoylsemialdehyde-pyridine to 3-succinoyl-pyridine. Genetic analyses indicated that the pao gene played an essential role in nicotine or pseudooxynicotine mineralization in strain HZN6, whereas the sap gene did not. This study provides novel insight into the nicotine-degrading mechanism at the genetic level in Pseudomonas spp.
Individual differences in disgust sensitivity modulate neural responses to aversive/disgusting stimuli

Little is known about how individual differences in trait disgust sensitivity modulate the neural responses to disgusting stimuli in the brain. Thirty‐seven adult healthy volunteers completed the Disgust Scale (DS) and viewed alternating blocks of disgusting and neutral pictures from the International Affective Picture System while undergoing fMRI scanning. DS scores correlated positively with activations in brain regions previously associated with disgust (anterior insula, ventrolateral prefrontal cortex–temporal pole, putamen–globus pallidus, dorsal anterior cingulate, and visual cortex) and negatively with brain regions involved in the regulation of emotions (dorsolateral and rostral prefrontal cortices). The results were not confounded by biological sex, anxiety or depression scores, which were statistically controlled for. Disgust sensitivity, a behavioral trait that is normally distributed in the general population, predicts the magnitude of the individual’s neural responses to a broad range of disgusting stimuli. The results have implications for disgust‐related psychiatric disorders.
Facial paralysis and vestibular syndrome in feedlot cattle in Argentina 1

Odriozola E. , Diab S. , Khalloub P., Bengolea A. , Lázaro L. , Caffarena D. , Pérez L. , Cantón G. & Campero C. 2009. Facial paralysis and vestibular syndrome in feedlot cattle in Argentina. Pesquisa Veterinária Brasileira 29(11):894-898. INTA EEA Balcarce, CC 276, (7620) Balcarce, Argentina. E-mail: eodriozola@balcarce.inta. gov.ar This paper reports 6 outbreaks of neurological disease associated with paralysis of the facial and vestibulocochlear nerves caused by intracranial space occupying lesions in feedlot cattle. The clinical signs observed were characterized by head tilt, uni or bilateral drooping and paralysis of the ears, eyelid ptosis, keratoconjunctivitis, and different degrees of ataxia. Morbidity and mortality rates ranged from 1.1 to 50% and 0 to 1%, respectively. Gross lesions observed included yellow, thickened leptomeninges, and marked enlargement of the roots of cranial nerves VII (facial) and VIII (vestibulocochlear). Histopathologically, there was severe, chronic, granulomatous meningitis and, in one case, chronic, granulomatous neuritis of the VII and VIII cranial nerves. Attempts to identify bacterial, viral, or parasitic agents were unsuccessful. Based on the morphologic lesions, the clinical condition was diagnosed as facial paralysis and vestibular syndrome associated with space occupying lesions in the meninges and the cranial nerves VII and VIII. Feedlot is a practice of growing diffusion in our country and this is a first report of outbreaks of facial paralysis and vestibular disease associated with space occupying lesions in Argentina.
Discourses on menopause — Part I: Menopause described in texts addressed to Danish women 1996—2004

To understand Danish women's very different ways of interpreting menopausal experiences and the way they construct meaning relating to menopause, it is necessary to include the context in which meaning is constructed as well as the background of cultural attitudes to menopause existing in the Danish society. Using documentary material, the aim of this article was to describe different discourses on menopause in Denmark that present themselves to menopausal women, and to discuss how these discourses may affect women's identity and constitute their scope of action. One hundred and thirty-two pieces of text under the heading or subject of `menopause' or `becoming a middle-aged woman', published from 1996 to 2004, were included. All material was addressed to Danish women, and consisted of booklets and informational material, articles from newspapers and magazines and popular science books. Seven different discourses on menopause were identified: the biomedical discourse; the `eternal youth' discourse; the health-promotion discourse; the consumer discourse; the alternative discourse; the feminist/ critical discourse; and the existential discourse. The biomedical discourse on menopause was found to be dominant, but was expanded or challenged by other discourses by offering different scopes of action and/or resting on different fundamental values. The discourses constructed and positioned individual women differently; thus, the women's position varied noticeably from one discourse to another. Depending on the discourse drawn upon, the woman's position could be that of a passive patient or that of an empowered woman, capable of making her own choices in relation to her health.
BURG: fast optimal instruction selection and tree parsing

1 Overview BURG is a program that generates a fast tree parser using BURS (Bottom-Up Rewrite System) technology. It accepts a cost-augmented tree grammar and emits a C program that discovers in linear time an optimal parse of trees in the language described by the grammar. BURG has been used to construct fast optimal instruction selectors for use in code generation. BURG addresses many of the problems addressed by TWIG [AGT89, App87], but it is somewhat less flexible and much faster. BURG is available via anonymous ftp from kaese.cs. wisc.edu. The compressed shar file pub/burg, shar. Z holds the complete distribution. This document describes only that fraction of the BURS model that is required to use BURG. Readers interested in more detail might start with Reference [BDB90]. 2 Input BURG accepts a tree grammar and emits a BURS tree parser. Figure 1 shows a sample grammar that implements a very simple instruction selector. BURG grammars are structurally similar to YACC's. Comments follow C conventions. Text between "%{" and "%}" is called the configuration section; there may be several such segments. All are concatenated and copied verbatim into the head of the generated parser, which is called BURM. Text after the second "%%", if any, is also copied verbatim into BURM, at the end. The configuration section configures BURM for the trees being parsed and the client's environment. This section must define NODEPTR_TYPE to be a visible typedef symbol for a pointer to a node in the subject tree.
The LAX1 and FRIZZY PANICLE 2 genes determine the inflorescence architecture of rice by controlling rachis-branch and spikelet development.

We have analyzed two mutants that exhibit altered panicle architecture in rice (Oryza sativa L.). In lax1-2, which is a new and stronger allele of the previously reported lax mutant, initiation and/or maintenance of rachis-branches, lateral spikelets, and terminal spikelets was severely prevented. In situ hybridization analysis using OSH1, a rice knotted1 (kn1) ortholog, confirmed the absence of lateral meristems in lax1-2 panicles. These defects indicate that the LAX1 gene is required for the initiation/maintenance of axillary meristems in the rice panicle. In addition to its role in forming lateral meristems, the wild-type LAX1 gene acts as a floral meristem identity gene which specifies the terminal spikelet meristem. A comparison of the defects in lax1-1 and lax1-2 plants suggested that the sensitivities to reduced LAX1 activity were not uniform among different types of meristems. In the fzp2 mutant panicle, the basic branching pattern of the panicle was indistinguishable from that of the wild type; however, specification of both terminal and lateral spikelet meristems was blocked, and sequential rounds of branching occurred at the point where the spikelet meristems are initiated in the wild-type panicle. This resulted in the generation of a panicle composed of excessive ramification of rachis-branches. The lax1-1 fzp2 double mutants exhibited a novel, basically additive, phenotype, which suggests that LAX1 and FZP2 function in genetically independent pathways.
Signature Morphology Effects of Squint Angle for Arbitrarily Moving Surface Targets in Spotlight Synthetic Aperture Radar

This investigation examines the phenomenology effects of the squint angle on the morphology of moving target smears in spotlight synthetic aperture radar (SAR). This analysis includes both the smears resulting from standard image formation applied to simulated radar measurements as well as the theoretical predictions for the central contours of the signatures. In particular, this paper generates the down-range and cross-range components of the predicted central 2-D contours of mover signatures, including the locations of the cross-range offsets. The analytics for squinted geometry include additional contributions in the signature contour equations that do not arise for the case of broadside imaging. These terms can affect the overall contour morphology, particularly in terms of shape and extent. Numerous examples are presented to demonstrate that the signature prediction equations yield excellent agreement with standard image formation with simulated radar data. Therefore, this analysis can provide an effective tool in predicting the shape, extent, and location of smears due to arbitrarily moving surface targets for squinted spotlight SAR.
Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency: a systematic review of randomized controlled trials.

BACKGROUND Vitamin B(12) deficiency is common, increasing with age. Most people are treated in primary care with intramuscular vitamin B(12). Several studies have reported equal efficacy of oral administration of vitamin B(12). OBJECTIVES We set out to identify randomized controlled trial (RCT) evidence for the effectiveness of oral versus intramuscular vitamin B(12) to treat vitamin B(12) deficiency. METHODS We conducted a systematic review searching databases for relevant RCTs. Outcomes included levels of serum vitamin B(12), total serum homocysteine and methylmalonic acid, haemoglobin and signs and symptoms of vitamin B(12) deficiency. RESULTS Two RCTs comparing oral with intramuscular administration of vitamin B(12) met our inclusion criteria. The trials recruited a total of 108 participants and followed up 93 of these from 90 days to 4 months. In one of the studies, mean serum vitamin B(12) levels were significantly higher in the oral (643 +/- 328 pg/ml; n = 18) compared with the intramuscular group (306 +/- 118 pg/ml; n = 15) at 2 months (P < 0.001) and 4 months (1005 +/- 595 versus 325 +/- 165 pg/ml; P < 0.0005) and both groups had neurological responses. In the other study, serum vitamin B(12) levels increased significantly in those receiving oral vitamin B(12) and intramuscular vitamin B(12) (P < 0.001). CONCLUSIONS The evidence derived from these limited studies suggests that 2000 microg doses of oral vitamin B(12) daily and 1000 microg doses initially daily and thereafter weekly and then monthly may be as effective as intramuscular administration in obtaining short-term haematological and neurological responses in vitamin B(12)-deficient patients.
The Cycloxygenase 2 (COX-2) Story: It's Time to Explain, Not Inflame

Despite initial promising reports that anti-inflammatory properties of cycloxygenase-2 (COX-2) inhibitors may confer anti-atherosclerosis effects and stabilize the atherosclerotic plaque, subsequent data from long-term clinical trials have shown that selective COX-2 inhibitors are associated with increased risk of cardiovascular events. The commonly cited explanation is that selective inhibition of COX-2 leads to depletion of prostacyclin, whereas the production of pro-thrombotic thromboxane by means of cycloxygenase-1 (COX-1) is unopposed. This hypothesis seems unlikely as the overall explanation, because low-dose aspirin does not decrease the increased risk associated with COX-2 inhibitors. Moreover, the risk associated with nonselective COX inhibitors may be similar to selective COX-2 inhibitors. Alternative hypotheses include (1) elevated blood pressure, (2) abnormal vascular remodeling, (3) inhibition of protective mechanisms against ischemia—reperfusion injury, and (4) inhibition of 15-epi-lipoxin production. Varying results in different experimental models may be related to the fact that COX-2 is involved in numerous cellular functions. Inhibiting COX-2 in inflammatory cells may have favorable effects, whereas in organs such as the heart and brain and/or blood vessels may have deleterious effects. Currently, the “selective COX-2 inhibitors” are not selective in the sense that they inhibit COX-2 in all tissues without predilection to inflammatory cells and, as a result, may summate to increase the risk of cardiovascular events.
Tumour‐associated macrophages in diffuse large B‐cell lymphoma: a study of the Osaka Lymphoma Study Group

Wada N, Zaki M A A, Hori Y, Hashimoto K, Tsukaguchi M, Tatsumi Y, Ishikawa J, Tominaga N, Sakoda H, Take H, Tsudo M, Kuwayama M, Morii E & Aozasa K (2012) Histopathology 60, 313–319 Tumour‐associated macrophages in diffuse large B‐cell lymphoma: a study of the Osaka Lymphoma Study Group
Glucagon‐like peptide 1 receptor agonists and cardiovascular risk in type 2 diabetes: a clinical perspective

Diabetes is associated with the development of premature atherosclerotic disease, including coronary heart disease and acute coronary syndromes. A late consequence of this process is the development of chronic heart failure, which contributes to the increased cardiovascular (CV) morbidity and mortality associated with diabetes. Reduction of cholesterol with statins and intensive blood pressure control significantly reduce vascular events in people with diabetes. Intensive treatment of glycaemia reduces microvascular complications, especially retinopathy and nephropathy, but has only a modest effect in reducing macrovascular complications. Attention has therefore focused on individual antidiabetic drugs or drug classes to determine if these have effects in reducing CV events beyond the reduction of blood glucose. Glucagon‐like peptide 1 (GLP‐1) receptor agonists are a class of injected therapies that enhance the incretin effect, increasing insulin release from the pancreas and reducing glucagon production. They also have a central effect, increasing satiety, and in routine clinical use are associated with reductions in body weight. Another possibly beneficial effect of these drugs is a slight but significant reduction in systolic blood pressure. Data from cohort studies have indicated no increase in CV events with GLP‐1 receptor agonists, and perhaps some reductions in CV events. The safety and possible CV benefit of these drugs is now being tested in large, multicentre, randomized, placebo‐controlled trials.