Miracle-dz/UniFAR-FTUs huggingface dataset:
Versatile distribution of wind power output for a given forecast value

The wind power output distribution for a given forecast value is often described by a theoretical distribution, such as Gaussian, Beta and Cauchy. However, the theoretical distributions could hardly simulate the actual wind power uncertainty for all situations. Moreover, the cumulative distribution function (CDF) or quantile function is more concerned by system operators than the probability density function (PDF). Nonetheless, the CDF of a theoretical distribution usually could not be expressed in a closed form and is commonly derived from the numerical integral of PDF. The estimation error of PDF may hence be cumulatively enlarged through the numerical integral process. Given this background, this paper presents a versatile distribution model that can simulate any shape of the actual distributions of wind power forecast errors. The CDF of the versatile distribution could be written as a closed form so it can be directly applied on fitting the actual CDF. The mathematical feature of the versatile distribution can also facilitate the dispatching decision-making and benefit power system analysis. The results demonstrate the feasibility and effectiveness of the proposed distribution model.
Cell type‐ and synapse‐specific variability in synaptic GABAA receptor occupancy

The degree of postsynaptic type A γ‐aminobutyric acid receptor (GABAA receptor) occupancy was investigated by using the benzodiazepine agonist zolpidem. This drug increases the affinity of GABAA receptors for γ‐aminobutyric acid (GABA) at room temperature (Perrais & Ropert 1999, J. Neurosci., 19, 578) leading to an enhancement of synaptic current amplitudes if receptors are not fully occupied by the released transmitter. We recorded miniature inhibitory postsynaptic currents (mIPSCs) from eight different cell types in three brain regions of rats and mice. Receptors in every cell type were benzodiazepine sensitive, as 10–20 μm zolpidem prolonged the decays of mIPSCs (151–184% of control). The amplitude of the GABAA receptor‐mediated events was significantly enhanced in dentate granule cells, CA1 pyramidal cells, hippocampal GABAergic interneurons, cortical layer V pyramidal cells, cortical layer V interneurons, and in cortical layer II/III interneurons. An incomplete postsynaptic GABAA receptor occupancy is thus predicted in these cells. In contrast, zolpidem induced no significant change in mIPSC amplitudes recorded from layer II/III pyramidal cells, suggesting full GABAA receptor occupancy. Moreover, different degrees of receptor occupancy could be found at distinct GABAergic synapses on a given cell. For example, of the two distinct populations of zolpidem‐sensitive mIPSCs recorded in olfactory bulb granule cells, the amplitude of only one type was significantly enhanced by the drug. Thus, at synapses that generate mIPSCs, postsynaptic receptor occupancy is cell type and synapse specific, reflecting local differences in the number of receptors or in the transmitter concentration in the synaptic cleft.
Unexpected role of TRPC6 channel in familial nephrotic syndrome: does it have clinical implications?

Focal and segmental glomerulosclerosis (FSGS) is a leading cause of glomerulonephritis and chronic kidney disease (CKD) in children and young adults ([1][1]). As much as one fifth of the ESRD population carries this diagnosis, and the proportion of ESRD attributed to FSGS has increased more than 10-
Measurement of exhaled nitric oxide in young children during tidal breathing through a facemask

Measurement of exhaled nitric oxide (eNO) offers a non‐invasive means for assessment of airway inflammation. The currently available methods are difficult to apply in preschool children. We evaluated four methods potentially applicable for eNO measurement during tidal breathing in young children. eNO was assessed during tidal breathing in 24 children, 2–7 yr old, using a facemask which separated nasal and oral airflow. Facemasks with and without a one‐way valve allowing exhalation through the nose were used. Expiratory flow control was not attempted. Measurements of eNO were performed both on‐line and off‐line. In 11 children, 8–12 yr old, measurements were compared with the standard single breath on‐line method. eNO was significantly lower applying the one‐way valve in on‐line and off‐line measurements in comparison with measurements without the valve [4.6 and 3.9 parts per billion (ppb) vs. 6.9 ppb and 6.5 ppb]. The mean within subject coefficient of variation (CV) was significantly lower in on‐line measurements with the one‐way valve (9.6%) compared with the other three methods (18.8, 27.7 and 29.3% respectively). Measurements with a facemask fitted with a one‐way valve yielded similar eNO levels as the standard single breath method (7.0 ppb vs. 6.9 ppb) and reproducibility (9.8% vs. 7.1%). In conclusion, reproducible measurements of eNO can be obtained without control of expiration flow using a facemask fitted with a one‐way valve on the nasal compartment. The likely explanation to this is that the one‐way valve reduces the admixture of nasal NO, thereby improving the reliability of eNO measurements.
Assessment of the visceral afferent and autonomic pathways in response to esophageal stimulation in control subjects and in patients with diabetes.

OBJECTIVE To examine the effects of esophageal stimulation on vagal afferent and efferent pathways in volunteers without diabetes and patients with diabetes. DESIGN Prospective physiological study. PARTICIPANTS Fourteen control subjects without diabetes and 6 patients with diabetes. INTERVENTIONS Electrical and mechanical stimulation of the esophagus. OUTCOME MEASURES Cortical evoked potentials and the power spectra of heart rate variability. RESULTS For the control subjects, there was a significant decrease in the ratio of the low frequency to high frequency (LF:HF) power (i.e., increased vagal efferent modulation) during stimulation. Reproducible cortical evoked potentials were obtained from all control subjects. In the 6 patients with diabetes, who had viscerosensory and autonomic neuropathy, the cortical evoked potentials showed an erratic non-reproducible response to electrical esophageal stimulation; however, the LF:HF ratio decreased in these patients during stimulation, suggesting an intact subcortical reflex circuit. CONCLUSIONS Vago-afferent fibres can be studied using minimally invasive techniques, and the power spectral analysis of heart rate variability permits study of autonomic vago-efferent pathways.
Prolonged airway and systemic inflammatory reactions after smoke inhalation.

STUDY OBJECTIVES Smoke inhalation has a prolonged, negative effect on pulmonary function. The immediate change in the airway after smoke inhalation is an intense inflammatory reaction. Obstructive airway disease commonly occurs several years after smoke inhalation, but few studies have focused on long-term reactions in the airway. This study investigated the long-term effects of smoke inhalation, by examining airway responsiveness, airway inflammation, and systemic effects. DESIGN Cross-sectional study. PATIENTS We assessed victims (n = 9) of smoke inhalation 6 months after they were exposed. INTERVENTIONS We studied the clinical symptoms, laboratory data, and pulmonary functions of the patients. We also performed the nonspecific bronchial challenge test with methacholine on these patients. In some patients, we reviewed pathologic specimens of bronchi and measured cytokines (tumor necrosis factor [TNF]-alpha, interferon [INF]-gamma, and interleukin [IL]-2) in serum and BAL fluid. RESULTS All the subjects complained of a productive cough, and three subjects had a mild degree of dyspnea on exertion. All but one subject had airway hyperresponsiveness to methacholine. The pulmonary function test results, however, were within normal limits, except for one subject who had a mild obstructive pattern of pulmonary function. Bronchial mucosal biopsy (n = 2) showed inflammatory changes with lymphocyte infiltration. Significantly greater concentrations of TNF-alpha (mean, 1,346.4 pg/mL vs 61.2 pg/mL; p < 0.05) and IFN-gamma (mean, 540.9 pg/mL vs 26.7 pg/mL; p < 0.05) were seen in the serum (n = 4) compared with control subjects. The serum IL-2 level was also increased (mean, 136.8 pg/mL vs undetectable); however, the increase was not significant compared with the control subjects. CONCLUSIONS These data suggest that inflammatory reactions in the airways and peripheral blood continue for at least 6 months after smoke inhalation.
Therapeutic efficacy of bromelain in impacted third molar surgery: a randomized controlled clinical study.

OBJECTIVE Bromelain is the name given to a family of proteolytic enzymes obtained from Ananas comosus, the pineapple plant. It is considered a potent anti-inflammatory and antiedematous substance. Surgery of impacted third molars in the outpatient setting is one of the procedures most often associated with postoperative pain and swelling. The aim of this study was to evaluate the efficacy of bromelain in reducing postoperative pain and swelling. METHOD AND MATERIALS 80 patients were recruited to the study from patients attending the Maxillofacial Surgery Unit of the Istituto Stomatologico Italiano, Milan, Italy, for impacted third molar surgery. At time 0 when surgery was performed, patients started simultaneous antibiotic and analgesic therapy. On the following day, patients were divided into two groups. Patients in group 1 were prescribed bromelain. Patients in group 2 were prescribed only the analgesic if required. Three parameters were evaluated: pain, edema, and erythema. The first evaluation visit was performed 3 hours after surgery, the second 48 hours after surgery, and the final evaluation 7 days after surgery. RESULTS Postoperative pain, edema, and erythema were significantly lower in the study group than in the control group. Analgesic consumption, both in terms of days of treatment and number of tablets taken, was slightly lower in the study group. Only one adverse event was recorded, which occurred in a patient in the control group. CONCLUSION The present study demonstrates an important anti-inflammatory and anti-edematous effect of bromelain. Statistical analysis shows that in the group treated with bromelain the inflammatory response was significantly less than in the control group.
Potential Role for ADAM15 in Pathological Neovascularization in Mice

ABSTRACT ADAM15 (named for a disintegrin and metalloprotease 15, metargidin) is a membrane-anchored glycoprotein that has been implicated in cell-cell or cell-matrix interactions and in the proteolysis of molecules on the cell surface or extracellular matrix. To characterize the potential roles of ADAM15 during development and in adult mice, we analyzed its expression pattern by mRNA in situ hybridization and generated mice carrying a targeted deletion of ADAM15 (adam15−/− mice). A high level of expression of ADAM15 was found in vascular cells, the endocardium, hypertrophic cells in developing bone, and specific areas of the hippocampus and cerebellum. However, despite the pronounced expression of ADAM15 in these tissues, no major developmental defects or pathological phenotypes were evident in adam15−/− mice. The elevated levels of ADAM15 in endothelial cells prompted an evaluation of its role in neovascularization. In a mouse model for retinopathy of prematurity, adam15−/− mice had a major reduction in neovascularization compared to wild-type controls. Furthermore, the size of tumors resulting from implanted B16F0 mouse melanoma cells was significantly smaller in adam15−/− mice than in wild-type controls. Since ADAM15 does not appear to be required for developmental angiogenesis or for adult homeostasis, it may represent a novel target for the design of inhibitors of pathological neovascularization.
Applying Permutation Tests and Multivariate Modification Indices to Configurally Invariant Models That Need Respecification

The assumption of equivalence between measurement-model configurations across groups is typically investigated by evaluating overall fit of the same model simultaneously to multiple samples. However, the null hypothesis (H0) of configural invariance is distinct from the H0 of overall model fit. Permutation tests of configural invariance yield nominal Type I error rates even when a model does not fit perfectly (Jorgensen et al., 2017, in press). When the configural model requires modification, lack of evidence against configural invariance implies that researchers should reconsider their model's structure simultaneously across all groups. Application of multivariate modification indices is therefore proposed to help decide which parameter(s) to free simultaneously in all groups, and I present Monte Carlo simulation results comparing their Type I error control to traditional 1-df modification indices. I use the Holzinger and Swineford (1939) data set to illustrate these methods.
Association of internal carotid artery injury with carotid canal fractures in patients with head trauma.

OBJECTIVE The purpose of our study was to determine the degree to which carotid canal fracture and other CT findings are associated with internal carotid artery (ICA) injury in patients with head trauma. MATERIALS AND METHODS Three neuroradiologists retrospectively evaluated CT scans and cerebral angiograms of 43 patients who underwent cerebral angiography within 7 days after blunt cranial trauma over a 5-year period. Seventeen patients underwent unilateral and 26 had bilateral carotid angiography. Angiograms were evaluated for ICA injury and CT scans were evaluated for carotid canal fracture, brain contusion, subarachnoid hemorrhage, basilar skull fracture, subdural hematoma, soft-tissue swelling, sphenoid sinus air-fluid level, and other skull fracture. We recorded the number of true-positive (+CT, +angiogram), true-negative (-CT, -angiogram), false-positive (+CT, -angiogram), and false-negative (-CT, +angiogram) studies. We determined the sensitivity, specificity, positive predictive value, and negative predictive value for each CT finding. RESULTS We identified 21 carotid canal fractures in 17 patients. Eleven ICA injuries were seen in 10 patients. Six patients with ICA injury had a carotid canal fracture. The presence of a carotid canal fracture had a sensitivity of 60% and specificity of 67% for detection of injury to the ICA passing through that canal. These values were similar to those for other CT findings. CONCLUSION Sensitivity, specificity, positive predictive value, and negative predictive value of carotid canal fracture were only moderately good for determining the presence of ICA injury and were similar to other CT findings not typically associated with ICA injury.
Localization of Green Fluorescent Protein Fusions with the Seven Arabidopsis Vacuolar Sorting Receptors to Prevacuolar Compartments in Tobacco BY-2 Cells1[W][OA]

We have previously demonstrated that vacuolar sorting receptor (VSR) proteins are concentrated on prevacuolar compartments (PVCs) in plant cells. PVCs in tobacco (Nicotiana tabacum) BY-2 cells are multivesicular bodies (MVBs) as defined by VSR proteins and the BP-80 reporter, where the transmembrane domain (TMD) and cytoplasmic tail (CT) sequences of BP-80 are sufficient and specific for correct targeting of the reporter to PVCs. The genome of Arabidopsis (Arabidopsis thaliana) contains seven VSR proteins, but little is known about their individual subcellular localization and function. Here, we study the subcellular localization of the seven Arabidopsis VSR proteins (AtVSR1–7) based on the previously proven hypothesis that the TMD and CT sequences correctly target individual VSR to its final destination in transgenic tobacco BY-2 cells. Toward this goal, we have generated seven chimeric constructs containing signal peptide (sp) linked to green fluorescent protein (GFP) and TMD/CT sequences (sp-GFP-TMD/CT) of the seven individual AtVSR. Transgenic tobacco BY-2 cell lines expressing these seven sp-GFP-TMD-CT fusions all exhibited typical punctate signals colocalizing with VSR proteins by confocal immunofluorescence. In addition, wortmannin caused the GFP-marked prevacuolar organelles to form small vacuoles, and VSR antibodies labeled these enlarged MVBs in transgenic BY-2 cells. Wortmannin also caused VSR-marked PVCs to vacuolate in other cell types, including Arabidopsis, rice (Oryza sativa), pea (Pisum sativum), and mung bean (Vigna radiata). Therefore, the seven AtVSRs are localized to MVBs in tobacco BY-2 cells, and wortmannin-induced vacuolation of PVCs is a general response in plants.
Effects of zinc supplementation on fatigue and quality of life in patients with colorectal cancer

ABSTRACT Objective To investigate the effects of oral zinc supplementation on fatigue intensity and quality of life of patients during chemotherapy for colorectal cancer. Methods A prospective, randomized, double-blinded, placebo-controlled study was conducted with 24 patients on chemotherapy for colorectal adenocarcinoma in a tertiary care public hospital. The study patients received zinc capsules 35mg (Zinc Group, n=10) or placebo (Placebo Group, n=14) orally, twice daily (70mg/day), for 16 weeks, from the immediate postoperative period to the fourth chemotherapy cycle. Approximately 45 days after surgical resection of the tumor, all patients received a chemotherapeutic regimen. Before each of the four cycles of chemotherapy, the Functional Assessment of Chronic Illness Therapy-Fatigue scale was completed. We used a linear mixed model for longitudinal data for statistical analysis. Results The scores of quality of life and fatigue questionnaires were similar between the groups during the chemotherapy cycles. The Placebo Group presented worsening of quality of life and increased fatigue between the first and fourth cycles of chemotherapy, but there were no changes in the scores of quality of life or fatigue in the Zinc Group. Conclusion Zinc supplementation prevented fatigue and maintained quality of life of patients with colorectal cancer on chemotherapy.
Accounting for Gender Equality in Secondary School Enrollment in Africa

type="main" xml:lang="en"> In addition to analyzing the characteristics of gender equality in secondary education enrollment in Africa, this paper empirically studies the key drivers of gender equality in secondary education enrollment, using cross-sectional time series data from 1970 to 2010. Our results show that the coefficient associated with the level of real GDP per capita is positive and statistically significant in both the overall Africa sample and in the sub-Saharan and North African samples. But the quadratic term of real GDP per capita is negative in sign and significant in the overall Africa and sub-Saharan African estimates. These provide evidence of a hump-shaped relationship between real GDP per capita and gender equality in secondary education enrollment in Africa. Our results also suggest that higher share of female teachers in secondary schools, increased democracy (at a decreasing rate), higher female share of the labor force, Christian dominance in a country, higher domestic investment rate, and being an oil-exporting country increase gender equality in secondary education enrollment in the continent. However, higher population growth tends to lower it. The policy implications and lessons of these results are discussed.
Rapid-prenatal diagnosis through fluorescence in situ hybridization for preventing aneuploidy related birth defects

BACKGROUND AND OBJECTIVE: Women with high-risk pregnancies are offered prenatal diagnosis through amniocentesis for cytogenetic analysis of fetal cells. The aim of this study was to evaluate the effectiveness of the rapid fluorescence in situ hybridization (FISH) technique for detecting numerical aberrations of chromosomes 13, 21, 18, X and Y in high-risk pregnancies in an Indian scenario. MATERIALS AND METHODS: A total of 163 samples were received for a FISH and/or a full karyotype for prenatal diagnosis from high-risk pregnancies. In 116 samples both conventional culture techniques for getting karyotype through G-banding techniques were applied in conjunction to FISH test using the AneuVysion kit (Abbott Molecular, Inc.), following standard recommended protocol to compare the both the techniques in our setup. RESULTS: Out of 116 patients, we got 96 normal for the five major chromosome abnormality and seven patients were found to be abnormal (04 trisomy 21, 02 monosomy X, and 01 trisomy 13) and all the FISH results correlated with conventional cytogenetics. To summarize the results of total 163 patients for the major chromosomal abnormalities analyzed by both/or cytogenetics and FISH there were 140 (86%) normal, 9 (6%) cases were abnormal and another 4 (2.5%) cases were suspicious mosaic and 10 (6%) cases of culture failure. The diagnostic detection rate with FISH in 116 patients was 97.5%. There were no false-positive and false-negative autosomal or sex chromosomal results, within our established criteria for reporting FISH signals. CONCLUSION: Rapid FISH is a reliable and prompt method for detecting numerical chromosomal aberrations and has now been implemented as a routine diagnostic procedure for detection of fetal aneuploidy in India.
Actual causes of death in Chaoyang District of Beijing, China, 2007

Objectives To identify and quantify major external (non-genetic) factors that contribute to death in Chaoyang District of Beijing, China in 2007. Methods The death registration data reported to the Center of Disease Control and Prevention of Chaoyang District of Beijing, China, during the year 2007, were obtained. The analysis was conducted in 2009 using the health risk factors identified by the World Health Report 2002 and the population attributable fractions of mortality from Global burden of disease and risk factors. The estimates of actual causes of death attributable to each risk factor were calculated by multiplying the population attributable fractions of mortality by the corresponding number of deaths of the subgroup or total population. Results The five leading actual causes of death in Chaoyang District of Beijing, China in 2007 were high blood pressure (2159 deaths, 18%), smoking (990, 8%), low fruit and vegetable consumption (968, 8%), high cholesterol (891, 7%), and physical inactivity (629, 5%). The pattern and ordering of these leading causes vary with sex and age specific subgroups. Conclusions More than half of the total number of deaths in Chaoyang District in 2007 could be attributed to a few major preventable risk factors. Although the study focused on only one district of Beijing in one single year, and is by no means comprehensive, its findings suggest that public health policies and programmes in China should address these public health concerns by focusing on these largely preventable risk factors for primary prevention.