Miracle-dz/UniFAR-FTUs huggingface dataset:
Corporate social responsibility and firm performance of Ghanaian SMEs

Purpose This paper aims to examine the influence of corporate social responsibility on financial performance of small and medium-sized enterprises (SMEs) in Ghana by using access to capital and firm reputation as mediating variables. Design/methodology/approach The authors collected primary data from 423 SMEs within the Accra Metropolis. Partial least squares estimation technique was used to analyze the data. Findings The authors documented evidence for a mechanism through which corporate social responsibility results in financial performance of firms: SMEs with improved corporate social responsibility practices are better positioned to achieve enhanced reputation, which translates into improved financial performance. Even though this study did not document a significant relationship between corporate social responsibility and access to finance by Ghanaian SMEs, the authors contend that looking at the positive relationship between them, SMEs can minimize their capital constraints by embarking on CSR practices, which can eventually translate into financial performance. Practical implications The authors recommend that for SMEs to enhance their reputation and increase their access to capital, which will eventually result in enhanced financial performance, corporate social responsibility practices should be a major part of their operations. Originality/value It contributes to our knowledge on how CSR practices lead to financial performance of SMEs in developing countries. In addition, this is the first of its kind to establish the relationship between CSR practices and financial performance of SMEs in Ghana by using access to capital and firm reputation as mediating factors.
Plasticity of NMDA receptor‐mediated excitatory postsynaptic currents at perforant path inputs to dendrite‐targeting interneurons

• NMDA receptors (NMDARs) activated by the neurotransmitter glutamate underlie certain forms of synaptic plasticity in the brain. • These receptors are also subject to plasticity and we have previously described both long‐term potentiation (LTP) and long‐term depression (LTD) of NMDARs in the principal granule cells of the dentate gyrus region of hippocampus. • The functional significance of these changes in NMDARs on hippocampal network activity depends on whether this occurs only on principal, excitatory neurons or if it also occurs on inhibitory interneurons. • Here we demonstrate differences in NMDAR subtype expression and plasticity in dendrite‐targeting interneurons compared to granule cells. • Interneurons displayed LTD of NMDAR‐mediated synaptic transmission in response to perforant path activation and had a high threshold for induction of LTP of NMDAR‐mediated synaptic currents, suggesting that opposing forms of plasticity at inputs to interneurons and principal cells may act to regulate granule cell dendritic integration and processing.
Linear free energy relationships on rate constants for dechlorination by zero-valent iron

By correlation analysis, molecular structural factors governing surface area-normalized rate constants ( k ¥ ) for dechlorination by zero-valent iron, were identified. Twenty-nine quantum chemical descriptors computed by MNDO, AM1 and PM3 Hamiltonians for gas-phase and the conductor-like screening model (COSMO) for incorporating solvent (H 2 O) effects were studied. Besides the energy of the lowest unoccupied molecular orbital ( E LUMO ), the character of carbon-chlorine bonds (C-Cl bonds) and especially the strength of C-Cl bonds was found significant in governing the magnitude of log k ¥ . By PLS analysis, six two-parameter linear free energy relationships (LFER) were obtained. The best two-parameter LFER model was the one using E LUMO and C (the Coulombic interaction energy of the two-center term for the C-Cl bonds) computed by PM3/H 2 O method as molecular structural descriptors. Chlorinated compounds with high E LUMO and C values tend to have low dechlorination rate constants.
Treatment of recalcitrant venous leg ulcers with autologous keratinocytes in fibrin sealant: A multinational randomized controlled clinical trial

In a multicenter trial, the effect of a commercially available combination of autologous keratinocytes (3–6 × 106/mL) with fibrin sealant (Tissucol Duo S Immuno, Baxter Hyland Immuno) on the healing of recalcitrant venous leg ulcers (duration >3 months) was compared with standard care. The primary endpoint was time to healing, and the secondary endpoint was number of healed ulcers in both groups. Both groups received compression therapy with short‐stretch bandages. Forty‐four (38.3%) of the 116 patients who had BioSeed®‐S treatment achieved complete healing of the target ulcer compared with 24 (22.4%) of 109 patients who received standard treatment. The advantage for treatment with BioSeed®‐S over standard treatment was statistically significant (chi‐square test: p=0.0106). Time to complete healing of ulcers: the log‐rank test for equality over strata revealed a superiority of treatment with BioSeed®‐S+compression (median: 176 days) over compression+standard care (median >201 days) (p<0.0001). This study, to date the largest multicenter study with autologous keratinocytes, provides evidence for its efficacy in the treatment of patients with therapy‐resistant chronic venous leg ulcers.
Foot Pressure Measurement Differences Between Boys and Girls With Reference to Hallux Valgus Deformity and Hypermobility

Background: Previous studies that compared foot pressures in boys and girls found that girls had greater peak pressures under the hallux than did boys. Only one of these studies considered plantar pressure measurements in children. The purpose of the study was to investigate the effect of gender on foot pressure measurements in children. Methods: This is a comparative study using the F-Scan pressure platform (F-Mat; Texscan® Boston, MA) on a sample of children attending a podiatric clinic. Pressure measurements and temporal parameters were measured in 61 children between the ages of 5 and 16 years. Associations between joint hypermobility and hallux valgus angle also were investigated. Results: Girls were found to have significantly greater peak pressure under the hallux, faster timing of heel contact to first metatarsal head loading, and a more medially placed center of pressure trajectory. No associations were found between these significant variables and hypermobility scores or hallux valgus angle. Conclusion: The results indicate that there are differences in pressure measurements between boys and girls, but the reasons for these remain unclear. Differences in pressure measurements in the feet of boys and girls may be useful in establishing the cause of foot pathologies for which a prevalence has been shown in boys or girls, such as hallux valgus deformity, which is known to be more frequent in females of all ages.
Layer-By-Layer Self-Assembly of Polyelectrolytic Block Copolymer Worms on a Planar Substrate

Cationic and anionic block copolymer worms are prepared by polymerization-induced self-assembly via reversible addition–fragmentation chain transfer (RAFT) aqueous dispersion copolymerization of 2-hydroxypropyl methacrylate and glycidyl methacrylate (GlyMA), using a binary mixture of a nonionic poly(ethylene oxide) macromolecular RAFT agent and either a cationic poly([2-(methacryloyloxy)ethyl]trimethylammonium chloride) or an anionic poly(potassium 3-sulfopropyl methacrylate) macromolecular RAFT agent. In each case, covalent stabilization of the worm cores was achieved via reaction of the epoxide groups on the GlyMA repeat units with 3-mercaptopropyltriethoxysilane. Aqueous electrophoresis studies indicated a pH-independent mean zeta potential of +40 mV and −39 mV for the cationic and anionic copolymer worms, respectively. These worms are expected to mimic the rigid rod behavior of water-soluble polyelectrolyte chains in the absence of added salt. The kinetics of adsorption of the cationic worms onto a planar anionic silicon wafer was examined at pH 5 and was found to be extremely fast at 1.0 w/w % copolymer concentration in the absence of added salt. Scanning electron microscopy (SEM) analysis indicated that a relatively constant worm surface coverage of 16% was achieved at 20 °C for adsorption times ranging from just 2 s up to 2 min. Furthermore, the successive layer-by-layer deposition of cationic and anionic copolymer worms onto planar surfaces was investigated using SEM, ellipsometry, and surface zeta potential measurements. These techniques confirmed that the deposition of oppositely charged worms resulted in a monotonic increase in the mean layer thickness, with a concomitant surface charge reversal occurring on addition of each new worm layer. Unexpectedly, two distinct linear regimes were observed when plotting the mean layer thickness against the total number of adsorbed worm layers, with a steeper gradient (corresponding to thicker layers) being observed after the deposition of six worm layers.
Structure of a Polycomb Response Element and In Vitro Binding of Polycomb Group Complexes Containing GAGA Factor

ABSTRACT Polycomb response elements (PREs) are regulatory sites that mediate the silencing of homeotic and other genes. The bxd PRE region from the Drosophila Ultrabithorax gene can be subdivided into subfragments of 100 to 200 bp that retain different degrees of PRE activity in vivo. In vitro, embryonic nuclear extracts form complexes containing Polycomb group (PcG) proteins with these fragments. PcG binding to some fragments is dependent on consensus sequences for the GAGA factor. Other fragments lack GAGA binding sites but can still bind PcG complexes in vitro. We show that the GAGA factor is a component of at least some types of PcG complexes and may participate in the assembly of PcG complexes at PREs.
Candida albicans and its metabolite gliotoxin inhibit platelet function via interaction with thiols

Summary Platelets bind to Candida albicans, the major cause of candidiasis. But in contrast to other microorganisms the fungus does not aggregate platelets. Gliotoxin (GT), which possesses immunosuppressive properties, is produced by various fungi, including the opportunistic pathogens Aspergillus fumigatus and C. albicans. Its mode of action involves the formation of mixed disulfides with host proteins. Disulfide exchanges play an important role in platelet activation. Therefore, the effect of C. albicans and GT on platelet function was tested. C. albicans yeast cells (5,000–10,000 cells/μl) and GT, in pathophysiologically relevant concentrations (0.05–0.5 μM), inhibited platelet fibrinogen binding, anti gp IIb/IIIa antibody PAC-1 binding, aggregation and procoagulant activity in a dose-dependent manner. Alpha granule release, measured via CD62P surface expression, was not affected. Addition of reduced glutathione partially counteracted the effect of C. albicans and GT on platelet fibrinogen binding and platelet aggregation. The C. albicans metabolite GT features antithrombotic properties in addition to its immunosuppressive functions. Since treatment with reduced glutathione partially counteracted the inhibitory effect of C. albicans yeast cells and GT on platelet fibrinogen binding, the antithrombotic activity is likely to depend on the disulfide bridge of this mycotoxin. GT production by C. albicans could contribute to its survival in the blood stream during vascular infections. The knowledge of the underlying mechanisms of the antithrombotic properties might help to treat fungal infections as well as thrombosis.
Effects of IV methylprednisolone on brain atrophy in relapsing-remitting MS

Background: IV methylprednisolone (IVMP) has been used to treat relapses in patients with relapsing-remitting (RR) MS, but its effect on disease progression is not known. Furthermore, there are no data on the impact of IVMP on T1 black holes or whole-brain atrophy. Objective: To determine the effect of IVMP on MRI measures of the destructive pathology in patients with RR-MS and secondarily to determine the effect of IVMP on disability progression in patients with RR-MS. Methods: The authors conducted a randomized, controlled, single-blind, phase II clinical trial of IVMP in patients with RR-MS. Eighty-eight patients with RR-MS with baseline Expanded Disability Status Scale (EDSS) scores of ≤5.5 were randomly assigned to regular pulses of IVMP (1 g/day for 5 days with an oral prednisone taper) or IVMP at the same dose schedule only for relapses (IVMP for relapses) and followed without other disease-modifying drug therapy for 5 years. Pulsed IVMP was given every 4 months for 3 years and then every 6 months for the subsequent 2 years. Patients had quantitative cranial MRI scans at study entry and after 5 years and standardized clinical assessments every 4 to 6 months. Results: Eighty-one of 88 patients completed the trial as planned, and treatment was well tolerated. Baseline demographic, clinical, and MRI measures were well matched in the two study arms. Patients on the pulsed IVMP arm received more MP than patients on the control arm of the study (p < 0.0001). Mean change in T1 black hole volume favored pulsed IVMP therapy (+1.3 vs +5.2 mL; p < 0.0001), as did mean change in brain parenchymal volume (+2.6 vs −74.5 mL; p = 0.003). There was no significant difference between treatment arms in the change in T2 volume or annual relapse rate during the study. However, there was significantly more EDSS score worsening in the control group, receiving IVMP only for relapses. There was a 32.2% reduction (p ≤ 0.0001) in the probability of sustained EDSS score worsening in the pulsed MP arm compared with the relapse treatment arm. At the end of the study, EDSS was better in the pulsed MP group (1.7 vs 3.4; p < 0.0001). Prolonged treatment with pulsed IVMP was safe and well tolerated; only two patients dropped out for toxic side effects over 5 years. Conclusions: In patients with RR-MS, treatment with pulses of IVMP slows development of T1 black holes, prevents or delays whole-brain atrophy, and prevents or delays disability progression. A phase III study of IVMP pulses is warranted.
α‐Defensins partially protect human neutrophils against Panton‐Valentine leukocidin produced by Staphylococcus aureus

α‐Defensins produced by neutrophils are important effector molecules of the innate immune system. In addition to their microbicidal effects, α‐defensins have the ability to neutralize bacterial toxins. Panton‐Valentine leukocidin (PVL) is the hallmark of community‐acquired methicillin‐resistant Staphylococcus aureus. Staphylococcus aureus that produce PVL are responsible for severe diseases, including necrotizing pneumonia. Polymorphonuclear neutrophils (PMNs) are the target cells of PVL action. The goal of this study was to elucidate the effect of a group of α‐defensins known as the human neutrophil peptides (HNPs) on the interactions between LukS‐PV and LukF‐PV, which compose PVL, and human PMNs. We observed that HNPs bound to both subunits of PVL and significantly decreased PVL pore formation in PMNs, with a maximum inhibition of 27%. When various HNP molecules were tested individually under the same conditions, we observed that HNP3, but not HNP1 or 2, decreased pore formation. Similarly, HNP3 significantly decreased PVL‐induced PMN lysis, with a maximum inhibition of 31%. Interestingly, HNPs did not affect LukS‐PV LukF‐PV oligomerization, LukS‐PV LukF‐PV binding to PMNs or calcium influx induced by PVL in PMNs. Our results suggest that HNP3 partially protects neutrophils against PVL by interfering with the conformational changes of PVL required to form a functional pore.
Iris location based on regional property and iterative searching

Iris recognition is one of common biometric identification technologies, and an important part of iris recognition is iris location, whose precision directly affects the accuracy of iris recognition. Fitting the inner and outer edge of iris as an approximate circle is a common iris location method, which thereby can lead to fitting errors between the location result and the actual edge. In order to solve this problem, the paper proposes an iris location algorithm based on regional property and iterative searching. The pupil area is extracted using the regional attribute of the iris image, and the iris inner edge is fitted exactly by iterating, comparing and sorting the pupil edge points; then the outer edge location is completed in an iterative searching method on the basis of the extracted pupil centre and radius. The results of the experiment show that in this algorithm, more accurate iris inner edge location can be achieved and a range of comprehensive advantages of faster location speed and higher location accuracy are.
Restorative Justice as a Response to Sexual Offending – Addressing the Failings of Current Punitive Approaches

This article explores the use of restorative justice as a response to sexual crime. The management of high risk sex offenders, particularly in the community post-release, has been a key focus of contemporary popular and political debates on sexual offending. Many offenders fail to come to the attention of the criminal justice system. For those that do, there is the almost blanket application of recent control in the community measures such as sex offender registries and community notification which have failed to prevent reoffending. The response by the media and the public to the presence of sex offenders in the community may also impede offender rehabilitation. The use of punishment alone via formal criminal justice is, therefore, an inadequate deterrent for sexual crimes. Although controversial, this article advocates the use of restorative practices with sexual crime as a proactive, holistic response to the problem and ultimately as a more effective means of reducing the incidence of sexual offences and sex offender recidivism. 1
Institutional Environment and Microfinance Performance in Sub‐Saharan Africa

This paper explores the impact of the institutional environment on the performance of 291 microfinance institutions in 34 sub-Saharan Africa countries during the period 2006 to 2014, by analysing the unbalanced panel data using fixed effects and generalized method of moments (GMM) estimation techniques. The panel regression results demonstrate strong evidence that a strong institutional environment has a positive effect on the performance of microfinance institutions in sub-Saharan Africa. More specifically, the findings reveal a positive and significant relationship between business freedom and microfinance performance in sub-Saharan Africa. These vital findings not only provide useful information to policy makers and key microfinance industry players, but also highlight the impact that institutional qualities have on microfinance performance.
Agency Discretion and Public Ethics: The Case of the Immigration and Naturalization Service

Abstract This article examines the public manager’s ethical responsibility to implement laws, and the consequences for agencies and clients when managers fail to do so. Using the Immigration and Naturalization Service (INS) as an example, it shows how the failure to implement immigration statutes equitably, and to perform the basic duties expected of the agency, resulted in the inequitable treatment of immigrants, possibly including the deportation of innocents. The analysis argues that agencies have a responsibility to inform Congress of implementation problems and to request the resources needed to address these problems, and that it is in the self-interest of Congress to address implementation problems quickly. When administrators act prudently and in their own self-interest, they are able to fulfill an obligation both to their clients and to the principals they serve.
Bilateral hilar lymphadenopathy due to Chlamydia pneumoniae infection

We here report a 5‐year‐old boy who presented with cough and bilateral hilar lymphadenopathy with a family history of sarcoidosis. The laboratory investigations did not confirm this diagnosis. The child was serologically proven to have Chlamydia pneumoniae infection. He responded well to a course of erythromycin resulting in complete resolution of his symptoms and the presenting radiographic findings on his initial chest X‐ray. Pediatr. Pulmonol. 2011; 46:1038–1040. © 2011 Wiley‐Liss, Inc.
Effect of Dimensions of Service Quality on the Brand Equity in the Fast Food Industry

Abstract Due to the increasing competition in the industry and service sectors, creating the powerful brands has great importance in these industries. One of the main factors that help to create a powerful brand is investment and improving the quality of services. Nowadays, the competition for improving the quality of services is raised as a key strategic issue for organizations that operate in the services sector. The aim of this research is to investigate how the dimensions of service quality affect the brand equity in the fast food industry. The customers of fast food industry (Restaurant Raphael) in Boushehr constitute the statistical population of this research. Given that the statistical population is unlimited, through sampling 390 questionnaires were distributed, collected and analyzed. For analyzing the data, the structural equations modelling was used by help of the software smart PLS. The results show that the entire dimensions of service quality of model SERVQUAL (tangible factors of services, reliability, responsiveness, assurance and empathy) have a positive and significant impact on the brand equity. It also became clear that among the five dimensions of quality of services, the tangible factors of services have the most impact on the brand equity in the fast food industry. So implementing the programs to enhance the quality of services will have to a very large extent a positive effect on increasing the brand equity in the fast food industry.
Earnings Management, Equity-based Compensation, Economic Conjuncture and Governance Mechanisms: A Comparative Study between France and the United States

Based on a sample of 159 French firms and 203 US firms for the period extending from 2003 to 2010, generally, we find that for both cases, managers engage in earnings’ management when they have a high percentage of equity-based compensation. The financial crisis was obviously important on managerial behavior and particularly on earnings management. Thus, the economic conjuncture is a new research question for equity compensation when it grants policy and earnings management. In addition, the governance mechanisms used to limit the opportunistic behavior of the manager also comes into play. Then we examine the governance mechanisms which encourage earnings management, particularly during allocation of equity compensation, where these two ideas have not been previously analyzed. We show that in contrast to a period of instability and economic recession, the manager has an incentive to earnings management to maximize his equity-based compensation during the period of economic growth. On the second point of research, we find on the one hand, that a governance mechanism which is effective in controlling earnings management that does not yield this result persists when awarding equity compensation. On the other hand, in the American case, the characteristics of the board of directors, and principally the compensation committee, and the ownership structure in the French case, can limit the opportunistic behavior of the manager during the allocation period of equity-based compensation.