Miracle-dz/UniFAR-FTUs huggingface dataset:
FIBROMAS VISCERAIS ASSOCIADOS AO FIBROPAPILOMA CUTÂNEO EM Chelonia mydas EM REABILITAÇÃO

Fibropapilomatose e uma enfermidade comum em tartarugas marinhas verdes (Chelonia mydas), mas pode ocorrer nas outras sete especies. Caracteriza-se pela presenca de massas papilares, arborizadas na superficie do corpo. Histologicamente, fibropapilomas consistem de hiperplasia epidermica, acantose, e hiperplasia dermica. Em algumas tartarugas com fibropapilomatose cutânea, massas identificadas histopatologicamente nos olhos, cavidade oral e em varios orgaos internos, sao vistas como fibromas. O protocolo de tratamento para individuos acometidos e a exerese tumoral, mas o reaparecimento das formacoes fibropapilomatosas externas ou fibrosas internas apos cirurgia pode ocorrer. Tres tartarugas verdes foram admitidas para reabilitacao no Aquario Municipal de Santos devido a presenca de fibropapilomas cutâneos em varias apresentacoes clinicas, em diferentes datas. Os animais sofreram procedimentos cirurgicos de exerese com eletrocauterio, eletroquimioterapia e criocirurgia em varios procedimentos sucessivos apos o reaparecimento dos tumores. Os animais vieram a obito, a despeito das tentativas cirurgicas, em datas distintas, todos apresentaram nodulacoes internas a necropsia, os fragmentos de orgaos foram colhidos e acondicionados em solucao aquosa de formol a 10%, processados histopatologicamente de maneira rotineira, corados com hematoxilina eosina e tricromico de Massom. Pulmoes, coracao e rins foram os orgaos envolvidos com crescimento neoplasico e histopatologicamente caracterizados como fibromas. Ressalta-se a necessidade de estabelecimento de um periodo de observacao clinica pos-cirurgica grande, antes de se reabilitar e liberar um animal possivelmente enfermo em vida livre.
Clinical spectrum and prognostic factors of pediatric ventricular tachycardia.

BACKGROUND There have been no studies on the clinical characteristics and prognostic factors of pediatric ventricular tachycardia (VT). METHODS AND RESULTS Eighty-one patients with pediatric VT were studied retrospectively at a single center. The median follow-up period was 6.0 years (0.7-23.5 years). Patients were categorized into 6 groups: idiopathic VT (IVT, n=37), catecholaminergic polymorphic VT (CPVT, n=10), congenital heart disease-associated VT (n=15), myocarditis-associated VT (n=8), cardiomyopathy-associated VT (CMP-VT, n=5) and miscellaneous. The age distribution of VT had 2 peaks (infant and teenager). VT with left bundle branch block configuration was more frequently nonsustained than VT with right bundle branch block configuration (61% vs 8%). Although 22% were asymptomatic, 38% experienced syncope or seizure and 16% had cardiac arrest. The overall mortality rate was 7.4%. The expected life span without cardiac arrest was <4 years in the CMP-VT group and the 10-year survival rate in CPVT patients was approximately 55%. Onset at infancy, monomorphic type and transcatheter/surgical ablation were related to the successful resolution of VT. Logistic regression analysis revealed that CPVT, CMP-VT, polymorphic VT and sustained VT were significantly correlated with death or cardiac arrest. CONCLUSIONS The clinical features and prognosis of pediatric VT differed with the VT type, clinical categories and onset age. Accurate diagnosis and proper treatment according to the clinical categories may improve the outcome.
In silico identification and characterization of conserved miRNAs and their target genes in sweet potato (Ipomoea batatas L.) Expressed Sequence Tags (ESTs)

The endogenous small non-coding micro RNAs (miRNAs), which are typically ~21–24 nt nucleotides, play a crucial role in regulating the intrinsic normal growth of cells and development of the plants as well as in maintaining the integrity of genomes. These small non-coding RNAs function as the universal specificity factors in post-transcriptional gene silencing. Discovering miRNAs, identifying their targets, and further inferring miRNA functions is a routine process to understand normal biological processes of miRNAs and their roles in the development of plants. Comparative genomics based approach using expressed sequence tags (EST) and genome survey sequences (GSS) offer a cost-effective platform for identification and characterization of miRNAs and their target genes in plants. Despite the fact that sweet potato (Ipomoea batatas L.) is an important staple food source for poor small farmers throughout the world, the role of miRNA in various developmental processes remains largely unknown. In this paper, we report the computational identification of miRNAs and their target genes in sweet potato from their ESTs. Using comparative genomics-based approach, 8 potential miRNA candidates belonging to miR168, miR2911, and miR156 families were identified from 23 406 ESTs in sweet potato. A total of 42 target genes were predicted and their probable functions were illustrated. Most of the newly identified miRNAs target transcription factors as well as genes involved in plant growth and development, signal transduction, metabolism, defense, and stress response. The identification of miRNAs and their targets is expected to accelerate the pace of miRNA discovery, leading to an improved understanding of the role of miRNA in development and physiology of sweet potato, as well as stress response.
Evaluation of the effectiveness of workplace exercise in controlling neck, shoulder and low back pain: a systematic review Efetividade do exercício físico em ambiente ocupacional para controle da dor cervical, lombar e do ombro: uma revisão sistemática

Background: Musculoskeletal disorders have been recognized as a worldwide health problem. One of the measures for controlling these disorders is workplace exercise, either at the workstation or in a separate environment within the company. However, there is controversy regarding the effectiveness and means of applying these interventions. Objectives: To assess and provide evidence of the effectiveness of workplace exercise in controlling musculoskeletal pain. Methods: The following databases were searched: PubMed, MEDLINE, Embase, Cochrane, PEDro and Web of Science. Two independent reviewers selected the elegible studies. Possible disagreements were solved by consensus. All randomized controlled clinical trials that evaluated exercise interventions in the workplace musculoskeletal pain relief were included. The PEDro scale (range=0-10 points) was used to rate the quality of the studies included in this review. Results and Conclusions: The electronic search yielded a total of 8680 references published in English. At the end of the selection process, 18 studies were included. Strong evidence was found to support the effectiveness of physical exercise in controlling neck pain among workers who performed sedentary tasks in offices or administrative environments, while moderate evidence was found for low back pain relief among healthcare and industrial workers who performed heavy physical tasks. These positive results were reported when the training periods were longer than 10 weeks, the exercises were performed against some type of resistance and the sessions were supervised. None of the studies evaluating sedentary workers reported positive results for controlling musculoskeletal shoulder pain. Further randomized controlled trials are needed to comparatively evaluate, among other aspects, the effects of light and heavy training for shoulder pain relief.
Real Power Loss minimization using symbiotic organisms search algorithm

This paper presents the application of a novel symbiotic organisms search (SOS) meta-heuristic algorithm for the optimization of Real Power Loss (RPL) of a transmission system. This issue is formulated as nonlinear equality and inequality constrained optimization, with an objective function of RPL minimization. Parameters such as transformers tap settings, location, series injected voltage magnitude and phase angle of UPFC are chosen as optimization variables. SOS is a recent swarm intelligence approach motivated by the biological interactions between the organisms in an ecosystem. The proposed SOS based algorithm is experimented on New England 39 bus system for its efficiency in the optimization of the RPL. Simulation results are evaluated and is compared with existing techniques such as interior point successive linear programming (IPSLP) and Bacteria Foraging Algorithm (BFA). It is observed from the results that, the proposed algorithm is efficient in RPL minimization.
Hierarchical decomposition of optimal control and information strategies in control-coding capacity of stochastic systems

The Control-Coding Capacity (CC Capacity) is defined as the maximum amount of information in bits/second, which can be encoded into randomized control strategies, transmitted over the control system, and decoded at its outputs, with arbitrary asymptotic small probability of error. This paper shows that optimal randomized control strategies which achieve the CC Capacity impose a natural hierarchical decomposition into two simpler sub-optimization problems, one related to the control objectives and one related to the information transmission objectives. The hierarchical decomposition states that control signals and communication signals interact in a specific order, optimal strategies are decentralized, and the information transmission rate is zero, unless the power allocated to the overall system is above a certain threshold, which is the minimum cost to achieve the control objectives.
Alpha-helical protein domains unify strength and robustness through hierarchical nanostructures

Hierarchical nanostructures, ranging through atomistic, molecular and macroscopic scales, represent universal features of biological protein materials. Here we show for the case of alpha-helical (AH) protein domains that this use of molecular hierarchies within the structural arrangement leads to an extended physical dimension in the material design space that resolves the conflict between disparate material properties such as strength and robustness, a limitation faced by many synthetic materials. An optimal combination of redundancies at different hierarchical levels enables superior mechanical performance without additional material use. Our analysis is facilitated by the application of a Hierarchical Bell model (HBM), which explicitly considers the hierarchical architecture of H-bonds within the protein structure, providing a structure–property relationship of strength properties of AH protein nanostructures. The HBM is validated by large-scale molecular dynamics simulations of several model protein structures. Our findings may enable the development of self-assembled de novo bioinspired nanomaterials based on peptide and protein building blocks, and could help in elucidating the mechanistic role of AHs in cell signaling and mechanotransduction.
Ecological Approaches in Medieval Rural Archaeology

In recent years, scientific methods of bio- and geoarchaeology have become increasingly important for archaeological research. Political changes since the 1990s have reshaped the archaeological community. At the same time environmental topics have gained importance in modern society, but the debate lacks an historical understanding. Regarding medieval rural archaeology, we need to ask how this influences our archaeological research on medieval settlements, and how ecological approaches fit into the self-concept of medieval archaeology as a primarily historical discipline. Based mainly on a background in German medieval archaeology, this article calls attention to more complex ecological research questions. Medieval village formation and the late medieval crisis are taken as examples to sketch some hypotheses and research questions. The perspective of a village ecosystem helps bring together economic aspects, human ecology and environmental history. There are several implications for archaeological theory as well as for archaeological practice. Traditional approaches from landscape archaeology are insufficient to understand the changes within village ecosystems. We need to consider social aspects and subjective recognition of the environment by past humans as a crucial part of human–nature interaction. Use of the perspective of village ecosystems as a theoretical background offers a way to examine individual historical case studies with close attention to human agency. Thinking in terms of human ecology and environmental history raises awareness of some interrelations that are crucial to understanding past societies and cultural change.
A Positive Patterning Advantage with Complex but not Simple Patterning: A Cue Constellation Approach

Determinants of a positive patterning advantage (that is, an advantage for positive patterning over negative patterning) in human causal reasoning were examined in an experiment that compared simple patterning discriminations (A, B vs. AB) to complex patterning discriminations (AB, BC, AC vs. ABC). As predicted by a cue constellation analysis of complex discriminations, a positive patterning advantage was found with complex patterning but not with simple patterning discriminations. This result may explain why some recent studies have found a positive patterning advantage where earlier studies had failed to find one. The interaction of patterning complexity with the positive patterning advantage appears to pose problems for rule-based accounts of patterning. The results support the view that associative theories of human causal reasoning are more easily distinguished from rule-based approaches when applied to conditions that make simple rules difficult to identify or implement.
Trends in Reproductive Performance and Condition of White-tailed Deer in Ohio

A BSTRACT . We compared the reproductive performance and condition of white-tailed deer ( Odocoileus virginianus ) collected in two regions of Ohio in 1996-99 with previous studies in 1962-67 (Nixon and others 1970; Nixon 1971) and 1981-83 (Stoll and Parker 1986). Statistical comparisons were limited to the 1981-83 and 1996-99 datasets because only summary data were available for 1962-67. We used uterine analysis to estimate reproductive parameters of roadkilled deer during 1982-83 and 1997-99, but ovarian analysis was used on deer obtained during fall hunting seasons in 1962-67. Pregnancy rates of fawns and yearlings declined in the farmland and hill country regions between 1982-83 and 1997-99, but no changes occurred in pregnancy rates of adult does. Fetal rates (fetuses/pregnant doe) of fawns and reproductive rates (fetuses/doe) of fawn and yearlings declined between 1982-83 and 1997-99. Body mass was collected at check stations in fall hunting seasons in the 1960s, 1981-82, and 1996-98, but antler beam and point characteristics were only measured in the 1981-82 and 1996-98 sampling periods. Mean body mass of all sex and age classes declined in the hill country, but fewer changes occurred in the farmland region. Mean antler beam diameter of yearling males declined in the hill country, but no differences were apparent in the farmland region. Reproductive performance and condition parameters were greater for deer in the farmland than in the hill country during both time periods. Declines in reproductive rates and in body condition have occurred as deer populations have increased in Ohio. Based on published sustained-yield tables (McCullough 1979; Downing and Guynn 1985), deer populations in the farmland region may currently exist at 35-40% of ecological carrying capacity, while the deer herd in the hill country may be near maximum sustained yield (MSY; 56% of ecological carrying capacity). Increased antlerless deer harvests may be required in the future to stabilize the population at MSY and maintain body condition and antler quality of deer because of a diminishing carrying capacity in southeastern Ohio.
Nimbolide Sensitizes Human Colon Cancer Cells to TRAIL through Reactive Oxygen Species- and ERK-dependent Up-regulation of Death Receptors, p53, and Bax*

TNF-related apoptosis-inducing ligand (TRAIL) shows promise as a cancer treatment, but acquired tumor resistance to TRAIL is a roadblock. Here we investigated whether nimbolide, a limonoid, could sensitize human colon cancer cells to TRAIL. As indicated by assays that measure esterase activity, sub-G1 fractions, mitochondrial activity, and activation of caspases, nimbolide potentiated the effect of TRAIL. This limonoid also enhanced expression of death receptors (DRs) DR5 and DR4 in cancer cells. Gene silencing of the receptors reduced the effect of limonoid on TRAIL-induced apoptosis. Using pharmacological inhibitors, we found that activation of ERK and p38 MAPK was required for DR up-regulation by nimbolide. Gene silencing of ERK abolished the enhancement of TRAIL-induced apoptosis. Moreover, our studies indicate that the limonoid induced reactive oxygen species production, which was required for ERK activation, up-regulation of DRs, and sensitization to TRAIL; these effects were mimicked by H2O2. In addition, nimbolide down-regulated cell survival proteins, including I-FLICE, cIAP-1, cIAP-2, Bcl-2, Bcl-xL, survivin, and X-linked inhibitor of apoptosis protein, and up-regulated the pro-apoptotic proteins p53 and Bax. Interestingly, p53 and Bax up-regulation by nimbolide was required for sensitization to TRAIL but not for DR up-regulation. Overall, our results indicate that nimbolide can sensitize colon cancer cells to TRAIL-induced apoptosis through three distinct mechanisms: reactive oxygen species- and ERK-mediated up-regulation of DR5 and DR4, down-regulation of cell survival proteins, and up-regulation of p53 and Bax.
Self-reported injury rates in New Zealand.

AIM The study aimed to obtain baseline information on the incidence and nature of self-reported injuries in New Zealand. METHODS A cross-sectional survey was conducted of approximately 400 randomly-selected households from each of 13 Territorial Local Authorities across New Zealand, giving a total sample size of 5282. Respondents were asked if anyone in their household had been treated by a medical doctor in the previous twelve months for any injuries and, if so, details of the injury event were recorded. RESULTS Forty one per cent of households reported that someone in the household had sustained an injury. The most common types of injuries were falls (33%), sports-related injuries (28%) and injuries caused by lifting an object (16%). Only eight per cent of the injuries required overnight hospitalisation. CONCLUSION The findings from this study indicate that the total burden of injury in New Zealand is much larger than estimated by routinely-collected injury hospitalisation data.
Genetic Polymorphisms in Adaptive Immunity Genes and Childhood Acute Lymphoblastic Leukemia

Background: Childhood acute lymphoblastic leukemia (ALL) has been hypothesized to have an infection- and immune-related etiology. The lack of immune priming in early childhood may result in abnormal immune responses to infections later in life and increase ALL risk. Methods: The current analyses examined the association between childhood ALL and 208 single-nucleotide polymorphisms (SNP) of 29 adaptive immune function genes among 377 ALL cases and 448 healthy controls. Single SNPs were analyzed with a log-additive approach using logistic regression models adjusted for sex, age, Hispanic ethnicity, and race. Sliding window haplotype analyses were done with haplotypes consisting of 2 to 6 SNPs. Results: Of the 208 SNPs, only rs583911 of IL12A, which encodes a critical modulator of T-cell development, remained significant after accounting for multiple testing (odds ratio for each copy of the variant G allele, 1.52; 95% confidence interval, 1.25-1.85; P = 2.9 × 10−5). This increased risk was stronger among firstborn children of all ethnicities and among non-Hispanic children with less day care attendance, consistent with the hypothesis about the role of early immune modulation in the development of childhood ALL. Haplotype analyses identified additional regions of CD28, FCGR2, GATA3, IL2RA, STAT4, and STAT6 associated with childhood ALL. Conclusion: Polymorphisms of genes on the adaptive immunity pathway are associated with childhood ALL risk. Impact: Results of this study support an immune-related etiology of childhood ALL. Further confirmation is required to detect functional variants in the significant genomic regions identified in this study, in particular for IL12A. Cancer Epidemiol Biomarkers Prev; 19(9); 2152–63. ©2010 AACR.
Worker Reallocation over the Business Cycle: The Importance of Job-to-Job Transitions

A transfer type copier having a rotatable drum of the type containing a long web of photosensitive material therein. The rotatable drum has a lid and a drum body, the lid being movable to permit replacement of the web and also to permit the web to be moved stepwise from inside the rotatable drum to the periphery thereof in order to position a new portion of the web on the drum body. The drum lid is movable to two positions, one of which permits the web to be removed and changed and in which the drum body is rotatable but not the lid, and the other in which the web can be moved stepwise and in which the lid remains rotatable with the drum body.
Numerical and experimental analysis of the performance of a reduced surface stirrer for reverberation chambers

The paper presents the numerical and experimental analysis carried out to check the performance of a way to reduce blade surface in mechanical stirring. In particular, the stirrer efficiency is quantified in terms of statistical independent positions, working volume field uniformity and Rician K-factor. The adopted numerical code reveals to be very reliable, compared to measurements, resulting in a powerful design tool.
Wideband Pattern-Reconfigurable Antenna With Switchable Broadside and Conical Beams

A wideband, pattern-reconfigurable antenna is reported that is, for example, a good candidate for ceiling-mounted indoor wireless systems. Switchable linearly polarized broadside and conical radiation patterns are achieved by systematically integrating a wideband low-profile monopolar patch antenna with a wideband L-probe fed patch antenna. The monopolar patch acts as the ground for the L-probe fed patch, which is fed with a coaxial cable that replaces one shorting via of the monopolar patch to avoid deterioration of the conical-beam pattern. A simple switching feed network facilitates the pattern reconfigurability. A prototype was fabricated and tested. The measured results confirm the predicted wideband radiation performance. The operational impedance bandwidth, i.e., |S 11| ≤ −10 dB, is obtained as the overlap of the bands associated with both pattern modalities. It is wide, from 2.25 to 2.85 GHz (23.5%). Switchable broadside and conical radiation patterns are observed across this entire operating bandwidth. The peak measured gain was 8.2 dBi for the broadside mode and 6.9 dBi for the conical mode. The overall profile of this antenna is 0. 13λ 0 at its lowest operating frequency.