Miracle-dz/UniFAR-FTUs huggingface dataset:
MRTFB suppresses colorectal cancer development through regulating SPDL1 and MCAM

Significance Myocardin-related transcription factor B (MRTFB) is a candidate tumor-suppressor gene identified in transposon mutagenesis screens of the intestine, liver, and pancreas. Using a combination of cell-based assays, in vivo tumor xenograft assays, and Mrtfb knockout mice, we demonstrate that MRTFB is a mouse and human colorectal cancer (CRC) tumor-suppressor gene that functions in part by inhibiting cell invasion and migration. Using whole transcriptome RNA sequencing in Mrtfb-knockdown cells, we also identify several MRTFB downstream genes, including a known tumor suppressor, MCAM, and a candidate tumor suppressor, SPDL1. Finally, we show that MCAM and SPDL1 are also human CRC tumor-suppressor genes that act downstream of MRTFB to regulate CRC growth and survival. Myocardin-related transcription factor B (MRTFB) is a candidate tumor-suppressor gene identified in transposon mutagenesis screens of the intestine, liver, and pancreas. Using a combination of cell-based assays, in vivo tumor xenograft assays, and Mrtfb knockout mice, we demonstrate here that MRTFB is a human and mouse colorectal cancer (CRC) tumor suppressor that functions in part by inhibiting cell invasion and migration. To identify possible MRTFB transcriptional targets, we performed whole transcriptome RNA sequencing in MRTFB siRNA knockdown primary human colon cells and identified 15 differentially expressed genes. Among the top candidate tumor-suppressor targets were melanoma cell adhesion molecule (MCAM), a known tumor suppressor, and spindle apparatus coiled-coil protein 1 (SPDL1), which has no confirmed role in cancer. To determine whether these genes play a role in CRC, we knocked down the expression of MCAM and SPDL1 in human CRC cells and showed significantly increased invasion and migration of tumor cells. We also showed that Spdl1 expression is significantly down-regulated in Mrtfb knockout mouse intestine, while lower SPDL1 expression levels are significantly associated with reduced survival in CRC patients. Finally, we show that depletion of MCAM and SPDL1 in human CRC cells significantly increases tumor development in xenograft assays, further confirming their tumor-suppressive roles in CRC. Collectively, our findings demonstrate the tumor-suppressive role of MRTFB in CRC and identify several genes, including 2 tumor suppressors, that act downstream of MRTFB to regulate tumor growth and survival in CRC patients.
The xylobiontic beetle fauna of old oaks colonised by the endangered longhorn beetle Cerambyx cerdo L innaeus , 1758 (Coleoptera: Cerambycidae)

Xylobionte Kaferfauna alter Eichen, die von dem gefahrdeten Bockkafer Cerambyx cerdo besiedelt sind (Coleoptera: Cerambycidae) Der Grose Eichenbock (Cerambyx cerdo l innaeus , 1758) hat in Mitteleuropa in den letzten 100 Jahren einen dramatischen Ruckgang in der Zahl der Vorkommen und in den Populationsgrosen erfahren. Als Frischholzbesiedler von Eichen beeinflusst die Art durch larvale Frastatigkeit die physiologischen Eigenschaften dieser Baume sowie deren Beschaffenheit als Habitat fur andere Organismen. Wir haben die Auswirkungen dieser Veranderungen auf die Zusammensetzung der holzbewohnenden Kaferfauna bei verschiedenen taxonomischen und funktionalen Gruppen unter sucht. Dabei vergleichen wir die mit Lufteklektoren erzielten Fange an 10 besiedelten und 10 unbesiedelten Eichen aus einem Untersu- chungsgebiet in Niedersachsen. Insbesondere viele seltene Bewohner von Baumhohlen und Holzmulm profitieren von der Anwesenheit dieser Bockkaferart und den dadurch entstehenden Mikrohabitaten. Besiedelte Baume beherbergen auch signifikant mehr Arten der Roten Liste. Wir diskutieren die Ei - genschaft von C. cerdo als Substratbereiter sowie die davon partizipierenden Arten. Freilich lasst nur ein Teil des Artenspektrums engere Zusammenhange mit Besiedlung durch den Grosen Eichenbock erkennen. Allerdings gehoren auch Arten mit loser Beziehung zu Cerambyx cerdo uber weite Strecken einer hochgradig bedrohten Kafergemeinschaft alternder Eichen an. Vor diesem Hintergrund sehen wir die unverzichtbare Rolle des Grosen Eichenbockes in von Eichen gepragten Okosystemen, wenn es um die Erhaltung der Artenvielfalt holzbewohnender Insekten geht.
Effects of Low-Fat and High-Fat Meals, with and without Dietary Fiber, on Postprandial Endothelial Function, Triglyceridemia, and Glycemia in Adolescents

The consumption of fiber-rich foods may negate the deleterious effects of high-fat meals on postprandial triglyceridemia and endothelial function. Despite supportive data in adults, little is known about the effects of high-fat and high-fiber foods on cardiovascular health parameters in pediatric populations. In this crossover trial, male and female adolescents (n = 10; 14.1 + 2.6 years; range 10–17 years) consumed (1) low-fat, low-fiber, (2) low-fat, high-fiber, (3) high-fat, low-fiber, and (4) high-fat, high-fiber breakfast meals in randomized order, each following an overnight fast. Baseline and 4 h post-meal blood was obtained for determination of glucose, insulin and triglyceride concentrations. Endothelial function was assessed via brachial artery flow-mediated dilation (FMD). Postprandial FMD was not significantly changed after any meal. However, regression analyses revealed a significant inverse relationship between the change in 4 h triglyceride concentration and change in 4 h FMD for the high-fat, low-fiber meal (β = −0.087; 95% CI = −0.138 to −0.037; p = 0.001) that was no longer significant in the high-fat, high-fiber meal (β = −0.044; 95% CI = −0.117 to 0.029; p = 0.227). Interpretation of these analyses must be qualified by acknowledging that between-meal comparison revealed that the two regression lines were not statistically different (p = 0.226). Addition of high-fiber cereal to the high-fat meal also reduced 4 h postprandial triglyceride increases by ~50% (p = 0.056). A high-fiber breakfast cereal did not attenuate postprandial glucose and insulin responses after consumption of a low-fat meal. While further work is needed to confirm these results in larger cohorts, our findings indicate the potential importance of cereal fiber in blunting the inverse relationship between postprandial hypertriglyceridemia and FMD after consumption of a high-fat meal in adolescents.
Investigation of Cycocel and Mycorrhizaa effecting yield and yield components of Peanut planting ( Arachis hypogaea L.) in different Planting Distances

In order to investigate the effect of Mycorrhizaa and CCC on peanut yield components of Gill kind in different planting distances, a factorial experiment has been conducted in the form of randomized complete block design in three replications at peanut research Centern of Guilan Province, Astaneh Ashrafieh city in agricultural year of 2012. Experimental factors includes three levels of planting distances (30*30, 40*40, 50*50), two levels of presence and absence of Mycorrhiza, two level of presence and absence of CCC. Results indicated that planting distance influence grain yield, total hollow podfs, ripe pods, the number sub branches and height of main stem and planting distance 40*40 was preferred than 30*30 and 50*50 m2. A significant interaction between CCC and spacing effects on yield were observed and the most amount of yield will be achieved at a distance of 40 * 40 and at the presence of CCC in 1852.56. Also, a significant interaction between Mycorrhiza and spacing effects on yield were observed and the most amount of yield will be achieved at a distance of 40 * 40 and at the presence of Mycorrhiza in 1831.14. CCC decreases the main branches height to 12.52cm and increase the number of tributaries (sub branches) to 0.2cm.
Phylogeny and systematics of the western Mediterranean Vella pseudocytisus-V. aspera complex (Brassicaceae)

The evolution and taxonomy of the core members of subtribe Vellinae (Brassicaceae), comprising Vella aspera, V. Bourgeana, and V. Pseudocytisus, is still poorly known. We reconstructed the evolutionary relationships among these taxa and other Vellinae and close Brassicaceae using nuclear ITS and plastid trnTF phylogenies, and analyzed the phenotypic traits that differentiate the infraspecific ranks of V. Pseudocytisus. Our phylogenetic analyses show: i) an early divergence of Succowia within the Brassiceae-Sisymbrieae sensu lato clade; ii) the nested positions of Vella bourgeana (syn. Euzomodendron bourgaeanum) and V. Aspera (syn. Boleum asperum) within the Vella clade; and iii) the split of 5 lineages within the V. Pseudocytisus clade (NW African subspecies glabrata 2x; SE Spain subspecies pseudocytisus 2x; C Spain subspecies pseudocytisus 4x; NE Spain subspecies paui 4x Alfambra Valley; and NE Spain subspecies paui 4x Turia Valley). Phenotypic traits support the differentiation of the diploid and tetraploid cytotypes of V. Pseudocytisus subsp. Pseudocytisus. Our data support the separation of Succowia from the Vellinae and the erection of a new subspecies within V. Pseudocytisus (Vella pseudocytisus subsp. Orcensis subsp. Nov.). They also corroborate the inclusion of Boleum and Euzomodendron within Vella.
A ug 2 01 6 UNIFORM PERFECTNESS , ( POWER ) QUASIMÖBIUS MAPS AND ( POWER ) QUASISYMMETRIC MAPS IN QUASI-METRIC SPACES

The aim of this paper is to investigate the uniform perfectness in quasi-metric spaces. One of the main results in this paper is the invariant property of uniform perfectness under quasimöbius maps in quasi-metric spaces. This result is built on the equivalence of uniform perfectness with homogeneous density, σdensity etc. The second main result is the relationships of uniform perfectness with (power) quasimöbius maps and (power) quasisymmetric maps. In the end, two applications of the first main result are given.
Radiation dose reference card for interventional radiology procedures: Experience in a tertiary referral centre

Abstract Background: Fluoroscopy-guided interventions can potentially increase radiation risk to patients, if awareness on angiographic imaging technique and radiation dose is neglected. Aim: To develop patient radiation dose reference card from standardized imaging techniques for various radiology interventions performed using flat detector based angiography system. Materials and Methods: Real-time monitoring of angiographic exposure parameters and radiation dose were performed for 16 types of radiological interventions. Effective dose (ED) was estimated from dose area product (DAP) using PCXMC Monte Carlo simulation software. Radiation risk levels were estimated based on Biological Effects of Ionising radiation (BEIR) report VII predictive models for an Asian population. Results: Pulse rates of 7.5 pps and 0.6 mm Copper filtration during fluoroscopy and 4 frames per second (fps) and 0.1-0.3 mm Cu filtration during image acquisitions were found to reduce radiation dose. Owing to increased number of image acquisitions, DAP was highest during diagnostic spinal angiography 186.7 Gycm2 (44.0–377.5). This resulted in highest ED of 59.4 mSv with moderate risk levels (1 in 1000 to 1 in 500). Most of the radiological interventions had low radiation risk levels (1 in 10,000 to 1 in 1000). Conclusion: The patient radiation dose reference card is valuable to the medical community and can aid in patient counselling on radiation induced risk from radiological interventions.
Ergodicity and exponential β-mixing bounds for a strong solution of Lévy-driven stochastic differential equations

We provides the following stability results for strong solution processes of Lévy-driven stochastic differential equations: (i) β-mixing property (absolute regularity) for every initial distributions; (ii) exponential β-mixing property for every initial distributions satisfying a suitable integrability condition. The sets of sufficient conditions given in terms of Meyn and Tweedies’ general theory of stability of Markov processes. By selecting test functions for the Foster-Lyapunov drift criteria suitably, the results can be used even if the driving Lévy measure has much heavy tails, hence generalizes the author’s previous result [21, Theorem 4.3]. The specific restriction on the driving Lévy measure is a very mild integrability condition only. Our results provide a fundamental tool for statistical inference for the process: the first result enables us to apply the law of large numbers; and moreover the second one establishes one of Yoshida’s three conditions in [42] for validity of asymptotic expansions associated with general mixing processes.
Parallel attentional facilitation of features and objects in early visual cortex

Abstract Selective attention can enhance the processing of attended features across the entire visual field. Attention also spreads within objects, enhancing all internal locations and task‐irrelevant features of selected objects. Here, we examine the extent to which attentional enhancement of a feature spreads across attended and unattended objects. Two fully overlapping counter‐rotating bicolored surfaces of light and dark random dots were presented on a gray background of intermediate luminance. This stimulus creates a percept of two separate semitransparent surfaces and allows the measurement of feature‐ and object‐based selections while controlling spatial attention. On each trial, human participants attended to a subset of dots defined by feature (luminance polarity) and object (surface) in order to detect brief episodes of radial motion while ignoring any events in the unattended groups of dots. Attentional selection was assessed by means of steady‐state visual evoked potentials (SSVEPs) and behavioral measures. SSVEP amplitudes recorded at medial occipital electrode sites were modulated both by surface‐based and luminance polarity‐based selection in a manner consistent with independent multiplicative enhancement of attentional effects in different dimensions in early visual cortex. This finding supports the view that feature‐based attention spreads across object boundaries, at least at an early stage of processing. However, SSVEPs elicited at more lateral electrode sites showed a hierarchical pattern of selection, potentially reflecting the binding of surface‐defining features with luminance features to enable surface‐based attention.
THE RELATION OF HYPERHOMOCYSTEINEMIA TO COGNITIVE FUNCTION AND BRAIN ATROPHY IN PATIENTS WITH MULTIPLE SCLEROSIS

Cognitive impairment may be a common even at the onset of multiple sclerosis (MS). In this case-control study, we tried to find out the probable relationship between homocysteine levels and cerebral atrophy or cognitive impairment in patients with multiple sclerosis. One hundred fifty six patients who had MS according to McDonald diagnostic criteria were included in this study. Patients’ age, gender, and educational level, MS duration and clinical type, disability, cognitive function state based on minimental state examination (MMSE), presence of hyperhomocysteinemia, and brain atrophy were evaluated. There was no statistically significant relationship between hyperhomocysteinemia and cognitive status. Total homocysteine levels had a significant correlation with MMSE score only in those patients with elementary level of education. Also total homocysteine levels and overall cerebral atrophy did not indicate significant relationship according to those independent variables mentioned above except in the patients with EDSS less than 6. When intercaudate ratio > 0.10 was applied as a criterion for cerebral atrophy, we found that hyperhomocysteinemia related significantly to intercaudate ratio > 0.10 in females, aged between 21 and 30 years, MS duration ≤ 5 years, primary progressive MS and relapsing-remitting MS clinical types, EDSS ≤ 3 and elementary level of education. We suggest applying MMSE only for the first step of cognitive function survey. In the next steps, much more exact test must be used (e.g. MSNQ). Also we can not suggest measuring plasma homocysteine level as criterion for monitoring the cognitive function in patients with MS.
Graph-Analytical Method of Determining Impedance in Electrical Transformers

This paper presents a graph-analytical method for determining the electrical impedance of alternate energy sources, especially small power transformers and current transformers in electric networks. Unlike conventional short-circuit and idle tests, according to proposed method, in this paper, transformer parameters are determined in a new way, which is based on measurement of voltages and currents on the active and reactive load (inductive or capacitive). The effectiveness of the proposed model was verified using an adapted simulation in the software package MATLAB Simulink. The simulation was performed for three types of ABB transformers with a 100% load. Simulation results were obtained for power transformers: , , . If we compare measurement result values of , , which are contained in a brochure for ABB transformers and those obtained through simulation, different tolerances are obtained. For reactance results, deviations are up to 20% for all three tested transformers. For results of active resistance tolerances are up to 5% for all three tested transformers. This method can be used not only to determine the active and inductive AC power source parameters but also to determine and analyze the impendence of electrical sources with high frequencies.
ANALYSIS OF EUCALYPTUS GLUED-LAMINATED TIMBER PORTICOS STRUCTURAL PERFORMANCE

Neste trabalho, avaliou-se o comportamento estrutural de porticos confeccionados a partir de tabuas coladas de eucalipto, utilizando madeira de Eucalyptus sp e adesivo resorcinol formaldeido. Foram projetadas, construidas e submetidas a testes de carga, ate a ruptura, tres unidades, em escala real, de porticos retos triarticulados, com vao livre de 5 metros e com inclinacao de 26o, aptos ao emprego de cobertura cerâmica. A quantidade de adesivo utilizada na construcao dos porticos foi de 250 g/m2 e a pressao de colagem de 1,3 MPa. O modelo de Hankinson foi empregado como estimador da resistencia de juntas coladas, sob diferentes ângulos entre as fibras. O valor medio obtido para a resistencia ultima das estruturas, foi de 4,63 vezes a carga de projeto, segundo criterios estabelecidos pela norma ABNT, 1997. As estruturas apresentaram desempenho mecânico satisfatorio e deformacoes inferiores as permitidas por norma. Concluiu-se pela viabilidade tecnica de se confeccionar porticos inteiramente colados com lâminas de madeira de pequena espessura.
Neurofilament light levels are associated with long-term outcomes in multiple sclerosis

Background: Neurofilament light chain (NfL) is a promising marker of disease activity/treatment response in multiple sclerosis (MS), although its predictive value for long-term clinical outcomes remains unclear. Objective: We measured NfL from a phase 3 trial in relapsing-remitting MS and investigated its association with outcomes after 8 and 15 years. Methods: NfL concentrations were measured by single molecule array assay in cerebrospinal fluid (CSF) from MS patients (n = 235) in a 2-year randomized clinical trial (RCT) of intramuscular interferon β-1a, and in serum (n = 164) from the extension study. Results: Year 2 CSF and Year 3 serum NfL were associated with brain parenchymal fraction (BPF) change over 8 years (p < 0.0001, r = −0.46; p < 0.05. r = −0.36, respectively) and were predictive of reaching Expanded Disability Status Scale (EDSS) ⩾ 6.0 at Year 8 (odds ratio (OR) (upper vs lower tertile) = 3.4; 95% confidence interval (CI) = 1.2–9.9, p < 0.05; OR = 11.0, 95% CI = 2.0–114.6; p < 0.01, respectively). Serum NfL concentration (Year 4) was predictive of reaching EDSS score ⩾6.0 at 15 years (OR (upper vs lower tertile) = 4.9; 95% CI = 1.4–20.4; p < 0.05). NfL concentrations were complementary to 2-year BPF change in predicting long-term outcomes. Conclusion: Serum and CSF NfL concentrations were associated with long-term clinical outcomes in MS patients and are promising biomarkers for disease severity stratification supporting treatment decisions.
Spatially Resolved Dust, Gas, and Star Formation in the Dwarf Magellanic Irregular NGC 4449

We investigate the relation between gas and star formation in subgalactic regions, ∼360 pc to ∼1.5 kpc in size, within the nearby starburst dwarf NGC 4449, in order to separate the underlying relation from the effects of sampling at varying spatial scales. Dust and gas mass surface densities are derived by combining new observations at 1.1 mm, obtained with the AzTEC instrument on the Large Millimeter Telescope, with archival infrared images in the range 8–500 μm from the Spitzer Space Telescope and the Herschel Space Observatory. We extend the dynamic range of our millimeter (and dust) maps at the faint end, using a correlation between the far-infrared/millimeter colors F(70)/F(1100) (and F(160)/F(1100)) and the mid-infrared color F(8)/F(24) that we establish for the first time for this and other galaxies. Supplementing our data with maps of the extinction-corrected star formation rate (SFR) surface density, we measure both the SFR–molecular gas and the SFR–total gas relations in NGC 4449. We find that the SFR–molecular gas relation is described by a power law with an exponent that decreases from ∼1.5 to ∼1.2 for increasing region size, while the exponent of the SFR–total gas relation remains constant with a value of ∼1.5 independent of region size. We attribute the molecular law behavior to the increasingly better sampling of the molecular cloud mass function at larger region sizes; conversely, the total gas law behavior likely results from the balance between the atomic and molecular gas phases achieved in regions of active star formation. Our results indicate a nonlinear relation between SFR and gas surface density in NGC 4449, similar to what is observed for galaxy samples.
Long non‐coding small nucleolar RNA host genes in digestive cancers

Although long noncoding RNAs (lncRNAs) do not have protein coding capacities, they are involved in the pathogenesis of many types of cancers, including hepatocellular carcinoma, cervical cancer, and gastric cancer. Notably, the roles of lncRNAs are vital in nearly every aspect of tumor biology. Long non‐coding small nucleolar RNA host genes (lnc‐SNHGs) are abnormally expressed in multiple cancers, including urologic neoplasms, respiratory tumors, and digestive cancers, and play vital roles in these cancers. These host genes could participate in tumorigenesis by regulating proliferation, migration, invasion and apoptosis of tumor cells. This review focuses on the overview of the roles that lnc‐SNHGs play in the formation and progression of digestive cancers.
The Value Relevance and Predictability of IFRS Accounting Information: The Case of GCC Stock Markets

This paper investigates some earning attributes (as the value relevance and predictability) of accounting information provided under International Financial Reporting Standards (IFRS ) in the Bahrain Bourse (BHB) and the Muscat Securities Market (MSM). The sample used in this research consists of 280 year-firm observations from 40 different companies listed in BHB; and a total 203 year-firm observations from 29 companies listed in MSM covering the period 2005-11. The findings of the study suggest that, for BHB, the adoption of IFRS leads to improvement in the value relevance of financial reporting contradictory predictability attribute as predictability of accounting information in listed companies of BHB is reduced after the adaption of IFRS. In MSM, the adoption of IFRS captures approximately similar value relevance of accounting information before adoption IFRS, however, predictability of accounting information improves after the adaption of IFRS. It was clear that the IFRS adoption by companies in MSM enhances the predictability of accounting information more than in BHB.