Miracle-dz/UniFAR-FTUs huggingface dataset:
Involvement of nuclear phosphatidylinositol‐dependent phospholipases c in cell cycle progression during rat liver regeneration

Nuclear lipid metabolism is involved in the regulation of cell proliferation. Modulation of the expression and activity of nuclear PI‐phospholipase C (PI‐PLC) has been reported during liver regeneration after partial hepatectomy, although it has not been determined whether different PLC isoforms play specific roles in the regulation of cell cycle progression. Here, we report evidence that the increased activity of nuclear PLCs in regenerating rat liver occurs before the peak of DNA replication and involves the enzyme activity associated to the chromatin and not that associated to the nuclear membrane. Immunocytochemical analyses indicate that PI‐PLC β1 isoform is exclusively localized at the chromatin level, PI‐PLC β1 co‐localizes with DNA replication sites much more than PI‐PLC γ1, which is also present at the nuclear envelope. These findings and the increased amount of PI‐PLC γ1 occurring after the peak of DNA replication suggest that PI‐PLC β1 and γ1 play different roles in cell cycle progression during regenerating liver. The increased activity of PI‐PLC β1 constitutively present within the hepatocyte nucleus, should trigger DNA replication, whereas PI‐PLC γ1 should be involved in G2/M phase transition through lamin phosphorylation. J. Cell. Physiol. 197: 181–188, 2003. © 2003 Wiley‐Liss, Inc.
Transplantation of cultured progenitor cells to the mammalian retina

Multipotent progenitor cells have now been isolated from the brain and retina, expanded in culture, and transplanted to the central nervous system (CNS). Work in rodent models has shown that progenitor cells derived from the CNS readily engraft in the diseased retina of mature recipients, where they develop morphologies appropriate to the local microenvironment and express mature markers, including the photoreceptor protein rhodopsin. There is also evidence for graft-associated rescue of host photoreceptors and preservation of light sensitivity in the degenerating retina. Graft survival does not necessarily require immune suppression, as CNS progenitors can behave as an immunoprivileged cell type. The use of biodegradable polymers results in an organised implant and further improves graft survival. Efforts are underway at present to extend this work to the pig, with initial results showing engraftment in both the neural retina and retinal pigment epithelium (RPE).
How exhaustive are reviews in research review articles?

In their recent ‘‘Research Review’’ article on a 46,X,idic(X)(q24) non-mosaic patient, Tsai et al. [2006] state that ‘‘[M]any cases were previously reviewed by Yu et al. [1980]’’ and purportedly compile ‘‘all cases of isodicentric X with breakpoints involving proximal q21 to distal qter that have previously been reported in the English literature. ’’ Although they compiled 10 previous non-mosaic patients, the authors overlooked at least four other similar cases as revealed by a search in Medline [Rivera et al., 1987; Dallapiccola et al., 1989; Suzuki et al., 1990; Jalal et al., 1996]. For instance, a 17-year-old Mexican girl with ovarian dysgenesis but neither short stature (height was 170 cm) nor other Turner syndrome stigmata was found to have a 46,X,idic(X)(q28) karyotype [Rivera et al., 1987]. Incidentally, this observation agrees with the assertion by Tsai et al. [2006] that patients with Xq27 breakpoints are universally tall (171.5–182 cm). As for the origin of the idic(X), Tsai et al. [2006] assume a maternal translocation in meiosis I on the basis of finding three distinct androgen receptor alleles in the patient, an interpretation further supported by her color blindness inherited from her father. We would posit however, that the idic(X) may alternatively have arisen from a single maternal X-chromosome after recombination as it is well known that the great majority of dicentric Xq isochromosomes are derived from a single Xchromosome either maternal or paternal [Jacobs et al., 1997]. Moreover, it seems to us that the inherited color blindness has no bearing on the time and mechanism of origin of the isodicentric. Otherwise, Tsai et al. [2006] include in their review of mosaic patients mostly (8/9) the cases already reviewed by Yu et al. [1980]; that is, they disregard 10 mosaic cases with an isodicentric X-chromosome and a 45,X cell line [Katayama et al., 1983; Lin and Wilson, 1983;Midroet al., 1988; Pettigrewet al., 1991; Dalton et al., 1998; Fernandez and Pasaro, 1998; Calvano et al., 2002; Petkovic et al., 2003]. Even if our letter is disregarded as inconsequential, it does cast light on the peer review process as well as on a (perceived or real) discrimination against authors from developing countries [Rumjanek, 1996; Horton 2000; Yousefi-Nooraie et al., 2006]; that is, we doubt that similar shortcomings have been allowed for authors like us.
Cyclophosphamide-bortezomib-dexamethasone compared with bortezomib-dexamethasone in transplantation-eligible patients with newly diagnosed multiple myeloma.

Introduction Cyclophosphamide-bortezomib-dexamethasone (CyBorD) is considered a standard induction regimen for transplant-eligible patients with newly diagnosed multiple myeloma (mm). It has not been prospectively compared with bortezomib-dexamethasone (Bor-Dex). We aimed to compare the efficacy of CyBorD and Bor-Dex induction in transplant-eligible patients. Methods In a retrospective observational study at a single tertiary centre, all patients with transplant-eligible mm who received induction with CyBorD or Bor-Dex between March 2008 and April 2016 were enrolled. Progression-free survival (pfs), response, and stem-cell collection for a first autologous stem-cell transplantation (ahsct) were compared. Results Of 155 patients enrolled, 78 (50.3%) had received CyBorD, and 77 (49.7%), Bor-Dex. The patients in the Bor-Dex cohort were younger than those in the CyBorD cohort (median: 57 years vs. 62 years; p = 0.0002) and more likely to have had treatment held, reduced, or discontinued (26% vs. 14.5%, p = 0.11). The stem-cell mobilization regimen for both cohorts was predominantly cyclophosphamide and granulocyte colony-stimulating factor (gcsf). Plerixafor was used more often for the CyBorD cohort (p = 0.009), and more collection failures occurred in the CyBorD cohort (p = 0.08). In patients receiving Bor-Dex, more cells were collected (9.9×106 cells/kg vs. 7.7×106cells/kg, p = 0.007). At day +100, a very good partial response or better was achieved in 75% of the CyBorD cohort and in 73% of the Bor-Dex cohort (p = 0.77). Median pfs was 3.2 years in the Bor-Dex cohort and 3.7 years in the CyBorD cohort (p = 0.56). Conclusions Overall efficacy was similar in our patients receiving CyBorD and Bor-Dex. After ahsct, no difference in depth of response or pfs was observed. Cyclophosphamide-gcsf seems to increase collection failures and hospitalizations in patients receiving CyBorD. Prospective studies are required to examine that relationship.
Utilization of breast cancer screening in a clinically based sample of women after BRCA1/2 testing.

We conducted a prospective, observational study to determine breast cancer screening practices among self-referred high-risk women who pursued genetic testing for BRCA1 and BRCA2 mutations. Of the 107 unaffected women included in this study, 41 were BRCA1/2 carriers and 66 women tested negative for a mutation previously identified in their family. All of the women underwent comprehensive pre- and posttest genetic counseling, and completed baseline and 12-month follow-up telephone interviews. The baseline (pretest) interview assessed potential predictors of mammography use, including demographics and psychosocial variables. During the year after the receipt of BRCA1/2 test results, 47% of the noncarriers and 59% of the carriers reported that they had had a mammogram [chi(2) (1, n = 107) = 1.35; P = 0.24]. Only 39% of carriers ages 25-39 reported having a mammogram, versus 74% of carriers age > or =40 [chi(2) (1, n = 41) = 5.10; P = 0.02]. Among noncarriers ages 50 and older, 83% had an annual mammogram. Factors independently associated with mammography use included age (<40, > or =40; odds ratio, 7.5; confidence interval, 2.6-21.5) and test result (odds ratio, 4.6; confidence interval, 1.1-18.7). The effects of perceived likelihood of having a BRCA1/2 gene alteration and the interaction between test result and perceived likelihood were not significant. As expected, most carriers (95%) and noncarriers (77%) obtained a clinical breast exam within the year after the receipt of test results. These data suggest that in carriers, overall, the use of breast cancer screening including mammography is good, although there was a relatively low uptake rate of mammography in younger carriers. Noncarriers had very good adherence to general population screening guidelines.
Alclometasone dipropionate: properties and clinical uses

Topical glucocorticosteroids are the mainstay of therapy in inflammatory skin disorders. The therapeutic effect of glucocorticosteroids depend on their chemical structure, physio-chemical properties, concentration of the active substance, pharmaceutical form, and affinity for specific receptors. Alclometasone dipropionate is a new-generation non-fluorinated topical glucocorticosteroid used in the treatment of inflammatory glucocorticosteroid responsive skin disorders (i.e. atopic dermatitis, contact dermatitis, psoriasis vulgaris, lichen planus) in adults and in pediatric patients older than 1 year of age. The unique properties of the compound result from the presence of a chlorine atom in position 7α which increases the potency of its effect without increasing the incidence of local and systemic adverse effects. Apart from its characteristic properties of glucocorticosteroids as a class (it is anti-inflammatory, antiproliferative, immunosuppressant and vasoconstrictive) the preparation has a beneficial effect on skin hydration which makes alclometasone the glucocorticosteroid of choice in dermatoses associated with pruritus and excessive skin dryness. Adverse reactions to alclometasone are rare and usually mild and transient. Alclometasone dipropionate is available in two formulations, i.e. 0.05% cream and 0.05% ointment.
Behavioral Inhibition and Activation in Posttraumatic Stress Disorder

Posttraumatic stress disorder (PTSD) is characterized by anxiety symptoms and impulsivity and aggression, which are thought to represent examples of excessive behavioral inhibition and activation, respectively. PTSD and traumatized control subjects performed the Stop-Signal Task to assess behavioral activation and inhibition simultaneously. PTSD subjects showed no evidence of the generally increased behavioral inhibition expected to accompany anxiety, but exhibited progressively decreased behavioral activation during acquisition of the task. However, when behavior was facilitated using monetary rewards, both PTSD and traumatized control subjects showed increases in behavioral activation, whereas PTSD subjects also showed significant disinhibition. These findings argue against PTSD patients being chronically inhibited and unresponsive to rewards, and the presence of disinhibition accompanying behavioral activation in these subjects may explain the impulsivity and aggression associated with PTSD.
Online Parameter Identification for Model-Based Sensorless Control of Interior Permanent Magnet Synchronous Machine

This paper proposes an online identification method that can accurately estimate the stator resistance and dq-axis stator inductances for the effective model-based sensorless control of interior permanent magnet synchronous motors (IPMSMs). The proposed affine projection algorithms are uniquely designed in the estimated rotating γ-δ frame to precisely identify the parameters mentioned above. The two time-scale approaches are employed in the affine projection algorithms to estimate the three electrical parameters. Despite the electrical parameter variations due to the temperature change and magnetic saturation during operation, the rich enough data are provided to the affine projection algorithms in the discrete-time domain to accurately retrieve the updated parameters. These correctly estimated parameters are adapted to the extended back electromotive force observer for the sensorless control of IPMSM drives. Hence, the adaptation of online updated parameters makes the observer stable and robust to parameter variations as compared to the conventional observer without updated parameters. The MATLAB/Simulink-based simulation results and experimental results via a prototype IPMSM test-bed having TMS320F28335 DSP are given to verify the accurate convergence of the estimated parameters, which results into a stable sensorless control system under various operating conditions.
Direct and Indirect Effects of Product Innovation and Product Quality on Brand Image: Empirical Evidence from Automotive Industry

This study examines the effect of product innovation and product quality on brand image with brand trust as mediator. Past studies paid less attention to empirically determine the relationship between the said variables on brand image and using brand trust as mediator between such independent and dependent variables. Therefore, this study aims to fill up this gap and contribute to the body of knowledge by examining the relationship between them. Data is collected using questionnaire from 287 passenger car users at shopping malls in Northern region of Malaysia. Specifically, systematic sampling procedure was followed during data collection. The data is analyzed using structural equation modeling (AMOS). The findings indicate that product innovation and product quality have significant relationship with brand image. The findings also reveal that product innovation and product quality have significant relationship with brand trust. Additionally, brand trust mediates the relationships between product innovation and brand image. It is also found that brand trust mediates the relationship between product quality and brand image. Based on these findings, several conclusions were made with some recommendations for future researches to strengthen our understandings toward the process of developing brand image.
A randomized trial of real-time automated clinical deterioration alerts sent to a rapid response team.

BACKGROUND Episodes of patient deterioration on hospital units are expected to increasingly contribute to morbidity and healthcare costs. OBJECTIVE To determine if real-time alerts sent to the rapid response team (RRT) improved patient care. DESIGN Randomized, controlled trial. SETTING Eight medicine units (Barnes-Jewish Hospital). PATIENTS Five hundred seventy-one patients. INTERVENTION Real-time alerts generated by a validated deterioration algorithm were sent real-time to the RRT (intervention) or hidden (control). MEASUREMENTS Intensive care unit (ICU) transfer, hospital mortality, hospital duration. RESULTS ICU transfer (17.8% vs 18.2%; odds ratio: 0.972; 95% confidence interval [CI]: 0.635-1.490) and hospital mortality (7.3% vs 7.7%; odds ratio: 0.947; 95% CI: 0.509-1.764) were similar for the intervention and control groups. The number of patients requiring transfer to a nursing home or long-term acute care hospital was similar for patients in the intervention and control groups (26.9% vs 26.3%; odds ratio: 1.032; 95% CI: 0.712-1.495). Hospital duration (8.4 ± 9.5 days vs 9.4 ± 11.1 days; P = 0.038) was statistically shorter for the intervention group. The number of RRT calls initiated by the primary care team was similar for the intervention and control groups (19.9% vs 16.5%; odds ratio: 1.260; 95% CI: 0.823-1.931). CONCLUSIONS Real-time alerts sent to the RRT did not reduce ICU transfers, hospital mortality, or the need for subsequent long term care. However, hospital length of stay was modestly reduced.
Influence of the pineal gland on the physiology, morphometry and morphology of pancreatic islets in rats

To investigate the influence of the pineal gland through melatonin secretion on the physiological and morphological parameters of pancreatic islets, we studied the plasma biochemistry and morphological and morphometric characteristics of the endocrine pancreas of male Wistar rats. The animals were distributed into five groups of ten rats each: NC - normal control group; NS - sham-operated group; Px (25) - pinealectomised group, studied 15-25 days after surgery; Px (70) - pinealectomised group, studied 60-70 days after surgery; ALX - alloxan monohydrate-treated group. Data are analyzed statistically by ANOVA and by the Kruskal-Wallis test. Although there was no significant difference in plasma glucose or insulin levels between the Px (25), Px (70) and NC groups, Px (25) animals showed a tendency to increased glucose and reduced insulin levels. The ALX group showed a clear elevation of plasma glucose and a reduction of plasma insulin compared to the other groups. Morphometric analysis showed a larger pancreatic islet area and a lower pancreatic islet density in the pancreas of Px (70) animals and an increase in degenerative pathological processes in the pancreatic islets of the Px (25) and ALX groups. The present results suggest that melatonin, in addition to acting on tissue sensitivity to insulin (as reported in other studies), affects the secretory action of beta cells, as demonstrated by the morphological and morphometric changes observed in pinealectomised animals.
Effect of zinc supplementation on duration of hospitalization in Tanzanian children presenting with acute pneumonia.

BACKGROUND Zinc supplementation prevents incident pneumonia in children; however, the effect for pneumonia treatment remains unclear. METHODS A randomized, double-blind, placebo-controlled trial of zinc supplements (daily 25 mg) adjunct to antibiotic treatment of radiology-confirmed acute pneumonia was conducted among hospitalized children (6-36 months) in Dar es Salaam, Tanzania. RESULTS The trial was stopped early due to low enrollment, primarily owing to exclusion of children outside the age range and >3 days of prior illness. Among children enrolled (n = 94), zinc supplementation indicated no beneficial effect on the duration of hospitalization (IRR: 0.69; 95% CI 0.45-1.06; p = 0.09) or the proportion of children who were hospitalized for <3 days (RR: 0.85; 95% CI: 0.57-1.25; p = 0.40) or <5 days (RR: 1.01; 95% CI: 0.83-1.23; p = 0.92) (IRRs and RRs >1.0 favor zinc). CONCLUSIONS Although underpowered, this randomized trial provided no evidence for a beneficial effect of zinc supplementation adjunct to antibiotics for hospitalized children.
Cooling garment treatment in MS: Clinical improvement and decrease in leukocyte NO production

Ten heat-sensitive patients with MS were randomly allocated in a cross-over study to wear a cooling garment for 60 minutes at 7 °C (active cooling) and 26 °C (sham cooling). In contrast to sham cooling, active cooling improved fatigue and postural stability with eyes closed and muscle strength. There was no decrease in tympanic temperature, but active cooling was associated with a 41% decrease in mean leukocyte nitric oxide (NO) production (p = 0.004). This effect on NO could be relevant because it blocks conduction in demyelinated axons.
A Gracefully Degrading Massively Parallel System Using the BSP Model, and Its Evaluation

The Bulk-Synchronous Parallel (BSP) Model was proposed as a unifying model for parallel computation. By using Randomized Shared Memory (RSM), the model offers an asymptotically optimal emulation of the Parallel Random Access Machine (PRAM). By using the BSP model with RSM, we construct a gracefully degrading massively parallel system using a fault tolerance (FT) scheme that relies on memory duplication to ensure global memory integrity and to speed up the reconfiguration. After a fault occurs, global reconfiguration restores the logical properties of the system. Work done during reconfiguration is shared equally among the live processors, with minimal coordination. We analyze, at the level of the BSP model, how the performance of a system may change as processors fail and the performance of the interconnection network degrades. We relate the change in overall system performance to the change in computation and communication load on the live processors. Further, we show how to estimate the overhead imposed by the FT scheme. We evaluate the reconfiguration time, the overhead, and graceful degradation of the system experimentally by an implementation on a Massively Parallel Processor (MPP). We show that the predictions about the degradation of the system and the overhead cost of the scheme are accurate.
Epidemiology of Dental Caries in the World

The oral health of children 12 years old is the object of several epidemiological studies conducted around the world. According to the World Health Organization (WHO, 1997), the importance given to this age group is due to the fact that it is this age that children leave primary school. Thus, in many countries, is the last age at which data can be easily obtained through a reliable sample of the school system. Moreover, it is possible that at this age all the permanent teeth except third molars, have already erupted. Thus, the age of 12 was determined as the age of global monitoring of caries for international comparisons and monitoring of disease trends. Even considering the large number of scientific evidence from several epidemiological studies in schoolchildren worldwide, the majority are regional studies. In addition, the information is too outdated for some countries, which does not make easy international comparison. The index that measures the number of permanent teeth decayed, missing and filled teeth (DMFT) is the common outcome for such studies. Although there are differences in both the sampling plan and the types of individual attributes collected at different times in history, epidemiology has been developing epistemological and methodological tools that allow revisit both old and recent data in order to understand the influence of environmental characteristics on individual outcomes, seeking correct the effect of aggregate, also known as ecological fallacy (Moreira & Nico, 2010). At the same time, the use of Geographic Information Systems (GIS) and statistical methods have allowed a more sophisticated processing of data since the observations are given an adequate spatial analysis. As for the health-disease process, perceiving it as a historical phenomenon, the health situation of a given society is the result of models of health care employees in the past. The interest in developing appropriate methodologies for knowledge and monitoring of social inequalities health has grown around the world. Area until recently restricted to a few academic groups, now finds conditions of highest use by health system managers, as a powerful instrument for establishing priorities agendas and evaluate the impact of adopted policies. The global oral health database is currently being developed as part of the WHO Global InfoBase and it provides for the outcome evaluation of national and community oral health promotion and disease prevention programmes. The data stimulate providers of oral health care in countries and health authorities to implement preventive oral care programmes by sharing experiences and ensures data for adjustment of ongoing programmes. Oral health