Miracle-dz/UniFAR-FTUs huggingface dataset:
Perception, motivation, satisfaction and revisit intention on Muay Thai event as a sport tourist attraction

The purpose of this study was to investigate foreign and domestic tourists’ perception,experience, satisfaction, motives and revisit intentions on Muay Thai event in Thailand. This study used the Leiper theory and the Theory of Planned Behavior (TPB), to examine tourists’ satisfaction, sport event attributes and sport motivation.Data were collected from 417 subjects, comprising foreign (50.1%) and domestic (49.9%) tourists attending Muay Thai events at Sanam Muay Rajadamnern stadium and Sanam Muay Lumpini stadium in Thailand. Foreign tourists’ monthly income was higher than domestic tourists. Event information sources (Marker Element) in Thailand among foreign and domestic tourists showed that both foreign and domestic tourists received Muay Thai information at their home or office via using several types of information sources such as from word of mouth communication, electronic communication, and mass communication. The mean scores of Muay Thai attributes actually experienced by foreign tourists ranged from 2.77 (SD = 1.95) to 5.92 (SD = 1.22),while mean scores for Muay Thai attributes for domestic tourists ranged from 4.00 (SD = 1.98) to 5.79 (SD = 1.21). The mean scores of Muay Thai attributes for both tourists were similar with the mean scores of tourists’ Motives for Attending Muay Thai events in Thailand from 2.38 (SD = 1.86) to 6.16 (SD = 1.55)for foreign tourists and from 4.07 (SD = 2.08) to 5.81 (SD = 1.50)for domestic tourists. In addition, the finding also indicated that all attributes dimensions were significantly correlated with behavioral intention to attend the Muay Thai event for both foreign and domestic tourists. However, the relationship between the attributes of Muay Thai experienced by foreign tourists were not significantly correlated with their attitudes,subjective norms and perceived behavioral control towards the event, while for domestic tourists, Muay Thai attributes were significantly correlated with these variables. The finding of this study suggests the best predictor of behavioral intentions in attending future Muay Thai event for domestic tourists was satisfaction (R2 change = 0.502), while foreign tourists was subjective norm (R2 change = 0.251).
Knowledge, attitude and practice of home-based care for HIV/AIDS patients by their family/ caregivers at Jimma Town.

BACKGROUND About 1.5 million people are currently living with HIV/AIDS in Ethiopia-one of the largest HIV infected populations in the world. The current prevalence rate of infection is estimated at 4.4% nationally. Hospital bed occupancy rate due to AIDS has reached over 50% in urban hospitals creating a severe burden to the health service system in the country, or else US $3.4 million is needed in order to increase their bed capacity. Here arises the need to look for a better way of caring for people living with HIV/AIDS. Home care would thus offer the only feasible option for this need as it can mobilize the considerable reservoir of caring and sympathy that exists within a community beyond that of cost cutting. The study was conducted to determine the knowledge, attitude and practice of family/caregivers regarding home-based care for people living with HIV/AIDS. METHODS This was a cross-sectional community-based study conducted among 274 family/caregivers who were giving care for people living with HIV/AIDS in urban setting of Jimma town from June - August 2005. A structured and pre-tested questionnaire was used to collect data on socio-demographic characteristics, knowledge and attitude towards home based care practice. Data collection was done by interviewing family/caregivers at their respective houses and analyzed using SPSS for windows version 11.0. RESULTS Over three fourth of the studied subjects (91.6%) were knowledgeable about home based care and 88.7% showed favorable attitude. Ninety two point eight percent agreed that home is a better place for the care of PLWHA than hospital. Single caregivers were about four times more likely to be knowledgeable about home care as compared to their counterparts (OR = 3.98 (95% CI: 0.50, 88.08), but the finding was not statistically significant (p > 0.05). Neighbors and friends were two times more likely to have favorable attitude towards HBC as compared to family members, OR = 1.96 (95% CI: 0.74, 5.21) but, the finding is not statistically significant (p > 0.05). CONCLUSION The study highlighted that the majority of family members/caregivers have good knowledge and favorable attitude towards HBC and over half favored this care. Therefore, appropriate use of the above promising findings and experience of innovative approaches of HBC from other countries is recommended for further, more organized and effective home-based care practice.
Antibodies to Pf155/RESA and circumsporozoite protein of Plasmodium falciparum in paired maternal‐cord sera from Nigeria

Paired maternal‐cord serum samples were analysed for antibodies to the P/155/RESA and circumsporozoite protein (CSP) antigens of Plasmodium falciparum. Malaria parasites were found in 2–6% (3/117) of cord blood and 22–4% (26/116) of maternal samples. Immunofluorescence assays detected P. falciparum‐specific IgG antibodies in all paired samples while P. falciparum‐specific IgM was detected in 5–8% (7/121) of cord samples. The positivity rates for antibodies to Pfl55/ RESA and (NANP)6 but not (EENV)6, a C‐terminal repeat sequence of Pf155/REAS, were significantly higher in maternal as compared with cord samples. Seropositivity rates to Pf155/RESA and (EENV)6 were not related to maternal parity group while positivity rates to the (NANP)6 peptide were higher in primiparae and multi‐par ae of 4 parity. These data confirm the transplacental transfer of P. falciparum‐Specific antibodies and the higher incidence of malaria parasitaemia in primiparae. The presence of P. falciparum‐. specific IgM in some cord samples suggests intrauterine sensitization of the foetus to malarial antigens.
Approach to the Assessment Irregularity and Cyclic Dynamics of Territorial Development

Purpose – The main purpose of this study is a modelling of assessment processes for irregularity and cyclical of dynamic regions development, which used to reduce inter-regional contrasts, disruptions and variations in a socio-economic development on base an effective regional financial policy.Design/methodology/approach – The conceptual provisions and model basis of an estimate of irregular and cyclic dynamics of the socio-economic development of any regions, which are functioning in some conditions of a high level of an uncertainty the external environment. At the same time, this external environment has a significant influence to increase of risks and losses in design making.Findings – The model basis presents as a complex of some interconnected modules: the module for estimate and analysis of the irregularity of the socio-economic development any regions; the module to form some management scenarios of the socio-economic development any regions. Targeted direction of the first module is an estimate of an interregional socio-economic differentiation, a detection of some disproportions in the regions development. Description of the second module is a forming of any management scenarios of the socio-economic development any regions which to direct to decrease of a level of the interregional differentiation while ensuring of a sustainable economic growth.Originality/value – Was formed the models complex of a differentiation of the develop regions which can provide a possibility for estimation of some sustainability for the cluster formations regions by a level of the socio-economic development and to make an analysis of their structural dynamics. Also was been developed a complex of a methodical ensuring for a system forecasting of cyclical dynamic of an economic territories growth. The main blocks of this complex are the forecasting of macroeconomic indicators considering some indicators of the cyclical development; a detection and analysis of any cyclical fluctuations indicators of the region development; a forecasting of some crisis and catastrophes in the socio-economic region development. Was been developed the model of an alignment of the socio-economic disproportions on the interregional level on base the fiscal or tax-budget state policy. For forecasting of some consequences change of fiscal policy can be used some scenario approach which realization is doing on base an imitation simulation.
LCK Is an Important Mediator of B-Cell Receptor Signaling in Chronic Lymphocytic Leukemia Cells

B-cell receptor (BCR) signals promote survival of chronic lymphocytic leukemia (CLL) cells, and it is believed that overexpressed and constitutively active Lyn mediates this signaling. Here, we show that CLL cells express lymphocyte-specific protein tyrosine kinase (LCK) and that inhibition of this Src family tyrosine kinase with the specific inhibitor [4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[3,2-d]pyrimidin-7-yl-cyclopentane (Lck-i)], or reduction of its expression with siRNA, blocks the induction of CD79a, Syk, inhibitor of IκB kinase (IKK), Akt, and extracellular signal–regulated kinase (ERK) phosphorylation by BCR cross-linking in these cells. Furthermore, we show that CLL cells with high levels of LCK expression have higher levels of BCR-mediated IKK, Akt, and ERK phosphorylation as well as cell survival than CLL cells with low levels of LCK expression. We also show that treatment of CLL cells with Lck-i inhibits BCR cross-linking–induced cell survival. Taken together, these data show a major role for LCK in proximal and distal BCR-mediated signaling in CLL cells and suggest that LCK expression is important in the pathogenesis of this disease. On a clinical level, these studies advocate the use of specific LCK inhibitors in the treatment of progressive CLL. Mol Cancer Res; 11(5); 541–54. ©2013 AACR.
Autonomy of Autonomic Dysfunction in Major Depression

Objective: To investigate cardiac autonomic dysfunction in patients with major depressive disorder (MDD). Research in this area has faced several limitations because of the heterogeneity of the disease, the influence of medication, and methodological shortcomings. Methods: Participants were 75 patients suffering from an acute recurrent episode of MDD and 75 matched controls. All participants were assessed at baseline for linear and nonlinear parameters of heart rate variability, QT variability and baroreflex sensitivity. Participants with MDD were reassessed after 7 to 9 days of treatment with either a selective serotonin reuptake inhibitor (SSRI) or a serotonin and noradrenaline selective reuptake inhibitor (SNRI) antidepressant. Results: In the initial examination, patients showed an overall shift of autonomic balance toward sympathetic predominance as compared with matched controls, with a decrease in parasympathetic parameters and baroreflex sensitivity, and an increase in sympathetically influenced QT variability. Overall, antidepressant treatment exacerbated this imbalance, with differential effects observed for SSRI and SNRI treatment. In contrast to autonomic dysfunction in other disorders, such as schizophrenia, autonomic dysfunction in MDD appeared to be independent of disease severity. Conclusions: Patients suffering from MDD show profound autonomic dysfunction, which is exacerbated by SNRI and to a lesser degree by SSRI treatment. This information could prove important when selecting antidepressant medication for patients at risk for cardiac arrhythmias. ANOVA = analysis of variance; BBI = beat-to-beat interval; BMI = body mass index; BRS = baroreflex sensitivity; bslope = bradycardic slope; DSM-IV = Diagnostic and Statistical Manual of Mental Disorders, 4th Edition; HAMD = Hamilton Depression Rating Scale; Hc = compression entropy; HF = high frequency of the heart rate variability power spectrum; HRV = heart rate variability; LF = low frequency of the heart rate variability power spectrum; LF/HF = ratio between the low and high frequency of the heart rate variability power spectrum; MANOVA = multivariate analysis of variance; MDD = major depressive disorder; QTV = QT variability; QTvi = QT variability index; SNRI = serotonin and noradrenaline selective reuptake inhibitor; PHVAR = probability of high variability sequences; PLVAR = probability of low variability sequences; RMSSD = square root of the mean squared differences of successive normal-to-normal intervals; RR-interval = interval between consecutive R waves in the electrocardiogram; SBP = systolic blood pressure; SPSS = statistical package for the social sciences; SSRI = selective serotonin reuptake inhibitor; tslope = tachycardic slope.
Influence of reciprocating single-file and rotary instrumentation on bacterial reduction on infected root canals.

AIM To compare the bacterial reduction achieved with reciprocating and rotary systems during root canal preparation. METHODOLOGY Sixty distobuccal root canals of maxillary molars were contaminated with Enterococcus faecalis broth culture. After an incubation period of 21 days, bacterial samples were collected and cultured on m-Enterococcus agar plates. The root canals were divided into five groups, according to the system used for instrumentation: WaveOne, Reciproc, ProTaper, Mtwo and manual instrumentation. The negative controls consisted of five uncontaminated root canals that were subjected to the same instrumentations as each of the experimental groups. Bacterial samples were collected immediately and 7 days after instrumentation. Statistical analysis was performed by paired t-tests and anova tests. RESULTS Compared with the samples before instrumentation, the bacterial count was significantly reduced after instrumentation in all groups, with no significant difference in bacterial count reduction amongst the reciprocating, rotary and manual techniques. However, the samples tested 7 days after instrumentation showed significantly higher bacterial counts than the samples tested immediately after instrumentation. CONCLUSIONS All systems tested reduced bacterial counts to a similar level.
BRAIN LIPIDS IN RATS FED A DIET SUPPLEMENTED WITH HEN EGGS OF MODIFIED LIPID CONTENT

The aim of this study was to research the impact of a diet supplemented with egg yolks of modified content, having in mind the type of fat added to the laying hens diet, on the brain lipids and their fatty acid composition in rats. During four weeks of the experiment, 64 Wistar rats, divided into four groups of 16 animals each (eight animals of both sexes), were fed the commercial rat feed (group C), or the feed that contained 70% of the commercial rat feed and 30% of freshly boiled yolks from the eggs originating from laying hens fed with 3% fish oil (group F), 3% palm olein (group P) or 3% lard (group L). Concentration and content of total lipids and total cholesterol, as well as the fatty-acid composition of the total brain lipids were determined in the lipid extracts of the rats brains. Under unfavourable conditions, which in our case could be high dietary intake of the total fat due to egg yolk addition, the amount of total fat in the brain tissue or the mass of the organ itself can be changed. Applied dietary treatments could also influence the level of de novo synthesis of total cholesterol in the rat brain. High dietary fat intake, as well as the fat quality regarding its fatty acid composition, appear to be able to significantly influence the fatty acid profile of the total brain lipids in adult rats, whereas the level and quality of the changes also depend on sex.
The continental margin is a key source of iron to the HNLC North Pacific Ocean

Here we show that labile particulate iron and manganese concentrations in the upper 500 m of the Western Subarctic Pacific, an iron‐limited High Nutrient Low Chlorophyll (HNLC) region, have prominent subsurface maxima between 100–200 m, reaching 3 nM and 600 pM, respectively. The subsurface concentration maxima in particulate Fe are characterized by a more reduced oxidation state, suggesting a source from primary volcagenic minerals such as from the Kuril/Kamchatka margin. The systematics of these profiles suggest a consistently strong lateral advection of labile Mn and Fe from redox‐mobilized labile sources at the continental shelf supplemented by a more variable source of Fe from the upper continental slope. This subsurface supply of iron from the continental margin is shallow enough to be accessible to the surface through winter upwelling and vertical mixing, and is likely a key source of bioavailable Fe to the HNLC North Pacific.
Outsourcing and Firm Performance – A Comparative Study of Swiss and Greek Firms

This article aims at analyzing (i) the factors determining the firms' propensity to outsource various processes (production of intermediate products, production of final products, R&D activities, ICT activities), and (ii) the impact of outsourcing on firms' innovation performance, as well as labor productivity. The integral investigation of the determining factors, as well as the impact of outsourcing on innovation and productivity based on the same data in a comparative setting (Switzerland versus Greece) are important new elements and contributions of this study to the existing empirical literature. It has been concluded that in both countries more innovative firms (R&D) were stronger inclined to outsourcing activities than less innovative ones, whereas on the contrary, the educational level of employees and the labor cost showed no effect on outsourcing in both countries. Also, the intensity of ICT use and organizational aspects, especially those related to the formal structure of workplace organization, were relevant for the Swiss firms but not for the Greek firms. With respect to the impact of outsourcing on performance, it has been concluded that it tends to enhance innovation, particularly process innovation, but only weakly productivity (at least directly). Copyright 2013 The Author 2012. Published by Oxford University Press on behalf of Associazione ICC. All rights reserved. , Oxford University Press.
Evaluating wildfire simulators using historical fire data

High-performance wildfire simulators allow the future location of a wildfire to be rapidly predicted. The accuracy of such simulators needs to be evaluated; this can be achieved by comparing simulated and observed spread for documented historical fires. A key issue relates to the accuracy of data obtained from historical fires, such as the time-varying fire location, fire-ground weather and accuracy of fuel type, load and structure data. A methodology used to evaluate the accuracy of wildfire simulators using historical fire data is presented and applied to the A USTRALIS wildfire simulator using the four distinct phases of a large-scale wildfire occurring in Western Australian sand-plain heathlands and a fire reconstruction report on this fire produced by a wildfire expert. Challenges encountered in performing this validation exercise are highlighted.
An amplifier-discriminator chip for the GLAST silicon-strip tracker

An amplifier-discriminator circuit has been designed for reading data from the Si-strip detectors of the Gamma Large Area Space Telescope (GLAST). For the 38 pF expected detector loading, an equivalent noise charge (ENC) of 1400 electrons has been demonstrated on a 16-channel chip with a power consumption of 150 /spl mu/W per channel. The typical r.m.s. threshold variation was under 500 electrons ENC. These results satisfy the requirements of the GLAST mission.
Cellular and humoral responses to influenza in gabonese children living in rural and semi-urban areas.

BACKGROUND With the current attention to the pandemic threat of avian influenza viruses, it is recognized that there is little information on influenza in Africa. In addition, the effects of influenza vaccination in African countries could be very different from the effects in regions with less exposure to microorganisms and parasites. METHODS To monitor the presence of influenza viruses and investigate the immunological responses to influenza vaccination, schoolchildren in semi-urban and rural regions of Gabon were studied. Influenza-specific antibody responses to the 3 strains represented in the vaccine were determined in the serum. Furthermore, cytokine responses were measured after in vitro stimulation of whole blood by influenza antigens, before and after vaccination. RESULTS Prevaccination titers of antibody against H3N2 were high. At vaccination, the titers of antibody against the 3 influenza strains increased significantly. The anti-H1N1 and anti-B responses after vaccination were weaker in rural schoolchildren than in semi-urban schoolchildren. Influenza-specific cytokine responses were induced within a week, showing significantly lower interferon- gamma and significantly higher interleukin-5 in the children from rural areas. CONCLUSIONS Prevaccination antibody levels indicated that influenza viruses circulate in Gabon. Altogether, influenza vaccination induces weaker immune responses in a rural population than in a semi-urban population of Gabonese schoolchildren.
Thrombocytopenia in lupus: baseline C3 as an independent risk factor for relapse

Thrombocytopenia in patients with systemic lupus erythematosus (SLE) requires immunosuppressive treatment to restore normal platelet counts and treat concomitant organ involvement in other systems.1–6 However, relapses are quite common during the course of the disease.7 From 1995 to 2004, 38 consecutive patients with SLE with a first episode of thrombocytopenia (platelet count 150 000). Severe thrombocytopenia (<20 000/μl) was recorded in 34.2% of patients with rare haemorrhagic manifestations. Organ involvement included, in descending order, arthritis (31.6%), renal disease (29%), rash (18.5%), manifestations of the central nervous system (13.2%) and serositis (9%). Low C3 levels …
Contribution of the collagen I alpha1 and vitamin D receptor genes to the risk of hip fracture in elderly women.

CONTEXT AND OBJECTIVE Hip fracture is partially genetically determined. The present study was designed to examine the contributions of vitamin D receptor (VDR) and collagen I alpha1 (COLIA1) genotypes to the liability to hip fracture in postmenopausal women. DESIGN The study was designed as a prospective population-based cohort investigation. SUBJECTS Six hundred seventy-seven postmenopausal women of Caucasian background, aged 70 +/- 7 yr (mean +/- SD), have been followed for up to 14 yr. Sixty-nine women had sustained a hip fracture during the period. MAIN OUTCOME Atraumatic hip fractures were prospectively identified through radiologists' reports. Bone mineral density (BMD) at the hip and lumbar spine was measured by dual-energy x-ray absorptiometry. GENOTYPES: The TaqI and SpI COLIA1 polymorphisms of the VDR and COLIA1 genes were determined. Using the Single Nucleotide Polymorphism database, VDR TT, Tt, and tt genotypes were coded as TT, TC, and CC, whereas COLIA1 SS, Ss, and ss were coded as GG, GT, and TT. RESULTS Women with VDR CC genotype (16% prevalence) and COLIA1 TT genotype (5% prevalence) had an increased risk of hip fracture [odds ratio (OR) associated with CC, 2.6; 95% confidence interval (CI), 1.2-5.3; OR associated with TT, 3.8; 95% CI, 1.3-10.8] after adjustment for femoral neck BMD (OR, 3.4 per SD; 95% CI, 2.3-5.0) and age (OR, 1.4 per 5 yr; 95% CI, 1.1-1.7). Approximately 20 and 12% of the liability to hip fracture was attributable to the presence of the CC genotype and TT genotype, respectively. CONCLUSION The VDR CC genotype and COLIA1 TT genotype were associated with increased hip fracture risk in Caucasian women, and this association was independent of BMD and age.