Miracle-dz/UniFAR-FTUs huggingface dataset:
MyD88 and Trif Signaling Play Distinct Roles in Cardiac Dysfunction and Mortality during Endotoxin Shock and Polymicrobial Sepsis

Background: Toll-like receptors (TLRs) such as TLR2, TLR4, and TLR9 contribute to the pathogenesis of polymicrobial sepsis. These TLRs signal via the common myeloid differentiation factor 88 (MyD88)-dependent pathways. TLR4 also signals through MyD88-independent but TIR domain-containing adaptor inducing interferon-&bgr;-mediated transcription factor (Trif)-dependent pathway. The role of the two signaling pathways in cardiac dysfunction during polymicrobial sepsis and endotoxin shock is unknown. Methods: Sepsis was generated by cecum ligation and puncture. Mice were divided into sham and cecum ligation and puncture groups or subjected to saline or endotoxin. Left ventricular function was assessed in a Langendorff apparatus or by echocardiography. Cytokines were examined using a multiplex immunoassay. Neutrophil migratory and phagocytic functions were assessed using flow cytometry. Results: In comparison with wild-type mice, MyD88−/− but not Trif−/− mice had markedly improved cardiac function and survival after cecum ligation and puncture. In comparison, both MyD88−/− and Trif−/− mice were protected from cardiac depression and mortality during endotoxin shock. Septic MyD88−/− but not Trif−/− mice had diminished cytokine production in serum and in peritoneal space in comparison with wild-type mice after cecum ligation and puncture. In contrast, both MyD88−/− and Trif−/− mice had attenuated serum cytokines in comparison with wild-type mice after endotoxin challenge. Neither MyD88 nor Trif signaling had any effect on neutrophil phagocytic function or bacterial clearance at 24 h of polymicrobial sepsis. Conclusions: These studies establish that MyD88 but not Trif signaling plays a critical role in mediating cardiac dysfunction, systemic inflammation, and mortality during polymicrobial sepsis. Both MyD88 and Trif are essential for cardiac depression and mortality during endotoxin shock.
Demand Uncertainty and the Capital-Labor Ratio: Evidence from the U.S. Manufacturing Sector

Richard Hartman (1976) and Duncan M. Holthausen (1976) showed that firms' input choices may be affected by demand uncertainty. Specifically, uncertain demand conditions may lead to firms operating with a lower capital-ratio. This result has potentially important implications for the analysis of factor demand and factor productivity. The author constructs measures of demand uncertainty and examines the above relationship for a sample of 125 U.S. manufacturing industries. Results show that there exists a significant negative relationship between demand uncertainty and the capital-labor ratio. Copyright 1991 by MIT Press.
Information Pursuit in Financial Statement Analysis: Effects of Choice, Effort, and Reconciliation

Prior research provides evidence that information affects financial statement users' judgments less when that information is provided in a less accessible format (e.g., information disclosed in a footnote or less prominent financial statement rather than being recognized on the income statement [Maines and McDaniel 2000]). We provide evidence that, conditional on users performing the analysis necessary to transform the financial statements to appear as if disclosed information had been recognized, that information may affect users' judgments more than it would have if it had been recognized initially. Our experiments are set in the context of constructive capitalization of operating leases. The first experiment manipulates three variables that we hypothesize will contribute to this effect: choice to use transformed financial statements, effort spent on the transformation process, and reconciliation of pre‐ and post‐transformation numbers. We provide evidence that, in the constructive‐capitalization settin.
Nephron‐sparing surgery

Surgical resection remains the cornerstone of treatment for RCC. RN is curative for most patients with localized RCC, and some with advanced RCC benefit from RN before systemic therapy. RCC is refractory to standard chemotherapeutic agents, and immunotherapy results in responses in 10–15% of patients, with rare individuals having a durable cure [8]. Several new molecularly targeted agents have shown promise in clinical trials, and two of these have recently been approved by the USA Food and Drug Administration for treating advanced RCC [9].
The Influence of the Provision of Online Channel Functions on Exporting Channel Performance: The Moderating Effect of International Experience

ABSTRACT The purpose of this research is to investigate the effect of the provision of two online channel functions on exporting channel performance, using international experience as a moderating variable. The study setting is Taiwan. The results confirm that the provision of online communication and transaction functions can increase exporting channel performance. Moreover, international experience can better facilitate the effect of the provision of online transaction functions on exporters’ channel performance for less-experienced firms rather than for experienced firms. However, its facilitation reverses in course of the provision of online communication functions (albeit in a different direction than hypothesized).
Performance Gender Gap: Does Competition Matter?

Using data for students undertaking a series of real-world academic examinations with high future payoffs, we examine whether the differences in these evaluations’ competitive nature generate a performance gender gap. In the univariate setting we find that women’s performance is first-order stochastically dominated by that of men when the competition is higher, whereas the reverse holds true in the less competitive or noncompetitive tests. These results are confirmed in the multivariate setting. Our findings, from a real-world setting with important payoffs at stake, are in line with the evidence from experimental research that finds that females tend to perform worse in more competitive contexts.
Can Subnational Autonomy Strengthen Democracy in Bolivia

Bolivia is one of the most radical and sincere of decentralization reformers. It recently implemented new reforms granting autonomy to departmental, regional, municipal, and indigenous and rural governments. What effects might these have on public investment patterns, government responsiveness, intergovernmental fiscal relations, the sustainability of public finances, and political accountability? I examine autonomies in light of both fiscal federalism theory and evidence on the effects of Bolivia's 1994 decentralization. By submitting new reforms to the dual rigors of theory and evidence, we can arrive at contingent projections of their likely effects. I identify adjustments to improve efficiency and sustainability in intergovernmental relations, and reduce horizontal imbalances. In sum, the reform has the potential to improve citizen participation, make government more accountable, and deepen Bolivian democracy. Copyright 2014, Oxford University Press.
Demand for Differentiated Products, Discrete Choice Models, and the Characteristics Approach

We propose a specific characteristics framework in order to construct linkages between alternative conceptual approaches to modelling product differentiation. First, it is shown that a demand system which satisfies the gross substitutes property imposes specific requirements on the locations of products. In particular, the dimension of the characteristics space must be larger than or equal to the number of products minus one. We then identify a method for casting a given demand system (subject to certain restrictions) into our characteristics framework. This is illustrated for the logit, probit and linear probability models of discrete choice theory. Finally, we find a characteristics representation of the CES representative consumer.
Dermatological Reactions to Lithium: A Critical Review of the Literature

This article reviews clinical reports of dermatological reactions to lithium. Such reactions include maculopapular, acneiform, and follicular eruptions, psoriasis, and other manifestations. Standard psychiatric texts offer the psychiatrist little information concerning the prevalence or seriousness of these reactions, nor do they discuss the effectiveness of various treatment alternatives. More surprisingly, most dermatology texts do not even describe skin reactions to lithium. Dermatological reactions to lithium may occur more commonly than previously documented, but with the exception of some psoriatic cases, management without the need for lithium discontinuation is usually possible.
Human leukocyte antigen HLADRB1 determinants susceptibility to gastroesophageal reflux disease.

BACKGROUND - Gastroesophageal reflux disease (GERD) is characterized by diverse symptoms. There is an evidence for a genetic component to GERD as supported by familial aggregation of this disease. OBJECTIVE - To investigate whether certain human leucocyte antigen genes HLA-DRB1 are associated with GERD. METHODS - Patients and controls were prospectively recruited from GIT center at Al-Kindy Teaching Hospital (Baghdad-Iraq) between January 2014 and July 2016. Sixty Iraqi Arab Muslims patients with a history of heartburn and dyspepsia compared with 100 Iraqi Arab Muslims controls. All study patients and control groups underwent upper gastrointestinal endoscopic examinations and their serums were analyzed for CagA antibodies Immunoglobulin G (IgG) for H. pylori. HLA-DRB1 genotyping were done to both groups. RESULTS - A total of 60 patients with erosive gastritis; GERD (Grade II and III) were evaluated, together with 100 controls. There is a significant increase of H. pylori infection (P=0.0001) in GERD patients than control group. HLA-DRB1* 15:01 was significantly increased in GERD patients in comparison with control group and an increased frequency of HLADRB1*11:01 in control group compared with patients group. CONCLUSION - There is an association between HLA-DRB1 *15:01 in GERD patients with H. pylori positive patients.
Information Dissemination and Portfolio Choice

The process of security price adjustment to the release of new information has long held the interest of the finance profession, both in academics and in practice. The efficiency of financial markets in reflecting new information significantly impacts the allocation of capital and income within the markets1 and, consequently, can affect social welfare. Thus, public, business, and investment policies are all related to an understanding of the functioning of security markets and their utilization of information. As a result, a significant body of economic research has considered the impact of information upon security markets under a number of alternative market structures. In this paper, we attempt to contribute to this literature by extending previous research in the two related areas of speculation and information dissemination.
Antidepressant-Like Effect of tramadol and its Enantiomers in Reserpinized Mice: Comparativestudy with Desipramine, Fluvoxamine, Venlafaxine and Opiates

Tramadol is a centrally acting analgesic that demonstrates opioid and monoaminergic properties. Several studies have suggested that tramadol could play a role in mood improvement. Moreover, it has previously been shown that tramadol is effective in the forced swimming test in mice and the learned helplessness model in rats, two behavioural modelspredictive of antidepressant activity. The aim of the present study was to test tramadol and its enantiomers in the reserpine test in mice, aclassical observational test widely used in the screening of antidepressant drugs. This test is a non-behavioural method where only objective parameters such as rectal temperature and palprebral ptosis are considered. Moreover, we compared the effects of tramadol and itsenantiomers with those of antidepressants (desipramine, fluvoxamine and venlafaxine) and opiates [morphine (–)-methadone and levorphanol]. Racemic tramadol, (–)-tramadol, desipramine and venlafaxine reversed the reserpine syndrome (rectal temperature and ptosis), whereas(+)-tramadol and fluvoxamine only antagonized the reserpine-induced ptosis, without any effect on temperature. Opiates did not reversereserpine-induced hypothermia. (–)-Methadone showed slight effects regarding reserpine-induced ptosis, morphine and levorphanol had no effect. These results show that tramadol has an effect comparable to clinically effective antidepressants in a test predictive of antidepressant activity, without behavioural implications. Together with other clinical and experimental data, this suggests that tramadol has an inherent antidepressant-like (mood improving) activity, and that this effect could have clinical repercussions on the affective component of pain.
Inequality, Leverage and Crises: The Case of Endogenous Default

The paper studies how high household leverage and crises can arise as a result of changes in the income distribution. Empirically, the periods 1920-1929 and 1983-2008 both exhibited a large increase in the income share of high-income households, a large increase in debtleverage of the remainder, and an eventual financial and real crisis. The paper presents a theoretical model where higher leverage and crises arise endogenously in response to a growing income share of high-income households. The model matches the profiles of theincome distribution, the debt-to-income ratio and crisis risk for the three decades prior to the Great Recession.
National Debates, Local Responses: The Origins of Local Concern about Immigration in Britain and the United States

Theories of inter-group threat hold that local concentrations of immigrants produce resource competition and anti-immigrant attitudes. Variants of these theories are commonly applied to Britain and the United States. Yet the empirical tests have been inconsistent. This paper analyses geo-coded surveys from both countries to identify when residents’ attitudes are influenced by living near immigrant communities. Pew surveys from the United States and the 2005 British Election Study illustrate how local contextual effects hinge on national politics. Contextual effects appear primarily when immigration is a nationally salient issue, which explains why past research has not always found a threat. Seemingly local disputes have national catalysts. The paper also demonstrates how panel data can reduce selection biases that plague research on local contextual effects.
CAN WE SPEAK OF A HIGH COMMITMENT MANAGEMENT ON THE SHOP FLOOR

The Commitment model a la Walton has been a key element in conceptions of human resource management (HRM). Is there though any evidence of its application to production workers? Drawing on the HRM literature the authors first develop some measures of practices which might be thought to contribute to high commitment management (HCM). Having acquired data on the extent to which organizations adopt these practices the authors then, using latent variable analysis, assess whether there is a common structure underlying it which represents some kind of HCM‐type approach to labour. In so doing they develop a construct to measure HCM relevant to manual workers. Basing the analysis on data from a representative sample of manufacturing plants in the UK, they conclude that HCM is being practised, albeit to a very varying degree. The research also reveals a growth in the use of HCM practices between 1986 and 1990, and that this has been mainly in practices already popular in 1986; hence the increased use of HCM has been more in plants for whom it was relatively insignificant in 1986, rather than a further heightening of its significance in plants for which it was important before. Using multiple regression analysis, the authors are also able to show that organizational factors rather than factors exogenous to the organization are significantly related to both the level of HCM, and its rate of change between 1986 and 1990. of overwhelming importance is the extent of the strategic integration of personnel management. the authors draw out the relevance of the study for the wider debate about HRM. In particular the results add some support for Walton's and Guest's universalistic theories of HCM, as opposed to what have been called matching or contingency theories of HCM, according to which it is only likely to be found in specific contexts where, for example, high quality is important for competitive advantage.
Understanding UKIP: Identity, social change and the left behind

In this article we explore the structural shifts which help explain the emergence of UKIP as a major radical-right political force in Britain. There are two distinct, but related, aspects to this story. The first is the changes to Britain's economic and social structure that have pushed to the margins a class of voters who we describe as the ‘left behind’: older, working-class, white voters with few educational qualifications. The second is long-term generational changes in the values that guide British society and shape the outlook of voters. These value shifts have also left older white working-class voters behind, as a worldview which was once seen as mainstream has become regarded as parochial and intolerant by the younger, university-educated, more socially liberal elites who define the political consensus of twenty-first-century Britain. We then move to consider the political changes that have further marginalised these voters, as first Labour and then the Conservatives focused their energies on recruiting and retaining support from middle-class, moderate swing voters. Finally, we show how UKIP has developed into an effective electoral machine which looks to win and retain the loyalties of these voters. Finally, we discuss the longer-term implications of the radical-right revolt, which has the potential to change the nature of party competition in Britain in the 2015 election and beyond.
Entrepreneurial Orientation, Social Networks, and Creative Performance: Middle Managers as Corporate Entrepreneurs

Though previous research has highlighted how important it is for middle managers to contribute to corporate entrepreneurship, little work has been done to explore how they produce creative performance by examining the direct, curvilinear and moderating effects of their entrepreneurial orientation and social networks. A total of 337 middle managers conducting marketing, R&D and project management in Taiwan are studied. The results suggest that middle managers' disposition towards proactiveness and innovativeness is positively related to their creative performance, and their internal bonding networks and upper management networks are found to strengthen the effects of entrepreneurial orientation on creative performance. However, middle managers' external bridging networks are found to have an inverted U‐shaped curvilinear relationship with their creative performance, and to weaken the effect of entrepreneurial orientation on creative performance. These findings echo the interactionist perspective of creativity, implying that middle managers should manage their social networks more carefully, as social interaction with network actors may either facilitate or inhibit their creativity at work.
Finance and Growth: Schumpeter Might Be Wrong in Our Era. New Evidence from Meta-Analysis

In the first meta-study on the finance-growth nexus, we bridge the gap between Schumpeterian authors and sympathizers of Andersen & Tarp (2003). Over 20 fundamental characteristics that have influenced the debate over the last decades are examined. The empirical evidence is based on 196 outcomes from 20 studies. For the investigated Andersen & Tarp hypotheses, while we find only partial support for their position on the lack of substantial empirical evidence on a positive finance-growth nexus, the stance that a negative nexus is characteristic of African and Latin American countries is strongly rejected. Schumpeter’s thesis might be wrong in our era because of: endogeneity-based estimations, publication bias and, effects of financial activity. A historical justification is also discussed.
Knowledge Sharing within Strategic Alliance Networks and its Influence on Firm Performance: The Liner Shipping Industry

With increasing ubiquity of globalisation and the knowledge-based economy, the significance of knowledge as a critical firm resource is widely acknowledged, whilst strategic alliances are increasingly employed as instruments for knowledge sharing. The progressive formation of prominent alliance networks has also spurred much research on the effects of alliance networks on firm performance. With scant maritime-related research on such areas and strategic alliances being rampant in liner shipping, it is important to understand the knowledge dynamics within liner shipping alliance networks and examine their impact on firm performance. An exploratory approach, via face-to-face interviews with liner shipping executives, was adopted to obtain detailed insights and understanding for all research objectives. The findings of this study revealed existing mechanisms of knowledge sharing within liner shipping alliance networks, illustrate how information sharing amongst partners enhances firm performance, and demonstrate the positive yet limited moderating effects of geographical proximity on the former relationship.
How Competitive is Cross-border Trade of Electricity? Theory and Evidence from European Electricity Markets

Abstract Integrating national markets is a major policy target in the European energy market. Yet, wholesale prices for electricity still differ significantly. Whether these price differences are caused only by limited interconnector capacities or also by lack of cross-border competition is an open question. To address this question, we develop a new approach to determine to which extent price differences stem from limited participation in cross-border trade. We derive a theoretical integration benchmark, using Grossman’s (1976) notion of a rational expectations equilibrium. We compare the benchmark to data from European electricity markets. The data reject the integration hypothesis and indicate that well informed traders do not engage in cross-border trade.
Immunolocalization of Androgen Receptor in the Developing Craniofacial Skeleton

Male predominance in metopic and sagittal craniosynostosis and in nonsynostotic plagiocephaly suggests a role for circulating androgens in early craniofacial development. Androgens have been documented to play an important role in postnatal skeletal growth, and the androgen receptor has been recently demonstrated in human and rat osteoblast-like cell lines and in human long bones. The purpose of this study was to describe the expression of androgen receptor in the fetal craniofacial skeleton. The heads of E18 fetal CD-1 male and female mice were fixed in 10% formalin, decalcified, and embedded in paraffin. Four- to 6-μm coronal and sagittal sections were stained with a monoclonal antibody specific to androgen receptor, which was detected by an avidinbiotin conjugate and peroxidase system. The sections were then examined for androgen receptor expression patterns. Strong androgen receptor immunoreactivity was observed in the dura mater of developing fetuses. Androgen receptor expression was also noted in cells lining the osteogenic fronts and in calvarial osteoblasts. Similar androgen receptor expression patterns were found in male and female mice. Androgen receptor is abundantly expressed in fetal dura mater and calvarial bone. This study confirms the presence of androgen receptor in the murine fetal craniofacial skeleton, suggesting a potential role for the anabolic effects of androgens in the developing craniofacial skeleton.