Miracle-dz/UniFAR-FTUs huggingface dataset:
Genotoxic Effect of Methotrexate on Bone Marrow Chromosomes and DNA of Male Albino Mice (Mus musculus)

Aim of the work-Methotrexate (MTX), a structural analogue of folic acid, is an antineoplastic and antirheumatic agent which is used in a variety of clinical schedules and combination therapy regimens in man. Material and methods- Sixty mice of nearly the same age were randomly categorized into four groups (one control and three treated groups with different doses of methotrexate). Mice of the treated groups 1, 2 and 3 were intraperitoneally injected with a single dose of methotrexate (2.5, 5 or 10 mg/kg b. wt. respectively) at the first day of the experiment. All the control and the treated animals were sacrificed after 24, 48 or 72 hour by cervical dislocation post treatment. Results-Methotrexate treatment induced structural and numerical chromosomal aberrations in male mice bone marrow cells which were significantly increased (P< 0.001) by dose and time. Structural aberrations were chromosomal gap, fragment, break, centromeric attenuation, deletion, centric fusion, ring formation, end to end association and beaded chromosomes. Numerical aberration was polyploidy. Also, methotrexate treatment decreased the mitotic index in bone marrow cells of all the treated mice in comparison with the control group by increasing dose and time of treatment. Comet assay results indicated that treatment with methotrexate significantly increased (P< 0.001) DNA damage in the blood leukocytes in dose and time dependent manner. Conclusion- It can be concluded that methotrexate induced genetic damage on the chromosomes and DNA content of male albino mice even after single treatment with low doses.
Language area localization with three‐dimensional functional magnetic resonance imaging matches intrasulcal electrostimulation in Broca's area

In this study, intraoperative electrocortical stimulation mapping (ioESM), the current gold standard for the localization of critical language areas, is compared with functional magnetic resonance imaging (fMRI) in a 14‐year‐old girl with medically intractable epilepsy caused by a tumor in the region of Broca's area. Prior to the operation, four different fMRI tasks that target inferior frontal language areas were applied. Prior to the resection, ioESM as well as fMRI detected no language areas at the exposed cortical area. After removal of the tumor, a unique opportunity presented itself, where ioESM could be performed in the depth of a now exposed and intact gyrus. One specific locus that was indicated to be a critical language area by multiple‐task fMRI was targeted. IoESM selectively confirmed the location of this language area to within an estimated 3 mm. We propose that the combined use of different fMRI tasks increases the sensitivity and specificity for the detection of essential language areas.
Prevalence of high-risk human papillomavirus infection in different cervical lesion among organized health-examination women in Shanghai, China.

BACKGROUND Cervical cancer is the second most common cause of death from cancer among women worldwide. Human papillomavirus (HPV) plays a central role in the etiology of cervical cancer. It is important to describe the prevalence of HPV infection in different types of cervical lesions and to explore the relation between HPV viral load and the severity of cervical lesions. METHODS To describe the HPV infection prevalence and viral load in different age groups, we retrospectively investigated 6405 cases of women who were organized by their units to take health-examination. They were given Hybrid Capture II tests between January 2005 and December 2006. The correlation between HPV viral load and pathology was assessed. RESULTS Overall HPV infection prevalence was 29.1% (1864/6405), while in women 18-20 years old it was 54.4% (31/57), the highest among all age groups. After declining rapidly, HPV prevalence stabilized at about 30.0% in women aged 30 and older. Of the 6405 women, 1483 women had a colposcopic biopsy and 33.2% (492/1483) were positive for HPV DNA. Twenty-one percent of women with a normal diagnosis (238/1095) had HPV infection, a statistically significantly lower prevalence than in women with cervical lesions, including those with cervical intraepithelial neoplasia (68.8% in CIN1, 66.7% in CIN2, and 76.5% in CIN3) or with cervical cancer (94.1%). The correlation coefficient between viral load and cervical lesion severity was 0.134, which was not statistically significant (P = 0.075). Viral load values in women with CINs and cervical cancer were calculated, and no significant differences were identified. CONCLUSIONS The prevalence of high-risk HPV infection among women attending hospitals for health-examination in Shanghai is similar to the worldwide rate. HPV viral load can distinguish cervical lesions from normal individuals but cannot adequately predict the severity of cervical lesions.
On Identification of Distribution Grids

Large-scale integration of distributed energy resources into distribution feeders necessitates careful control of their operation through power flow analysis. While the knowledge of the distribution system model is crucial for this analysis, it is often unavailable or outdated. The recent introduction of synchrophasor technology in low-voltage distribution grids has created ample opportunity to learn this model from high-precision, time-synchronized measurements of voltage and current phasors at various locations. This paper focuses on joint estimation of admittance parameters and topology of a polyphase distribution network from the available telemetry data via the lasso, a method for regression shrinkage and selection. We propose tractable convex programs capable of tackling the low-rank structure of the distribution system and develop an online algorithm for early detection and localization of critical events that induce a change in the admittance matrix. The efficacy of these techniques is corroborated through power flow studies on four three-phase radial distribution systems serving real and synthetic household demands.
Uterine insulin-like growth factor-1: regulation of expression and its role in estrogen-induced uterine proliferation.

THE response of the uterus to estrogen is a complexphenomenon involving numerous biochemical events (1). The most dramatic outcome of estrogenization of the immature uterus is the proliferation of various cell types. It is customary to divide the response of the uterus to estrogen into two major temporal phases. In the early phase, within the first 4 h after estrogen administration, there is an increase in uterine wet weight (2), glucose metabolism (3), histamine depletion (4), and RNA polymerase activity (5). One of the early events that is likely to be important in the proliferative response of the uterus to estrogen is activation of protooncogenes which encode nuclear regulatory proteins (6–8) and the enhanced expression of growth factors and their receptors (9) and cAMP-independent protein kinase (10). The intermediate and late phase (4–48 h after estrogen) responses include increases in protein and RNA synthesis and an increase in uterine dry weight and DNA content (11, 12).
Organic Agricultural Producer Strategies in Supply Chain of Sustainable Agriculture Network, Chachoengsao Province, Thailand

Organic agricultural market in Thailand has incessantly grown from organic consumers, whilst organic agricultural areas in Thailand are merely 213,183 Rai or 7% of total agricultural areas nowadays. Thai government has undertaken policy to enhance the strengthening for the organic agricultural producer. However, most of organic agricultural producers in the country are members of sustainable agricultural networks. Therefore, this study aimed to 1) investigate organic agricultural product supply chains of farmers who are members of sustainable agricultural network, and 2) study the strategies of organic agricultural producer in supply chain of sustainable agriculture network. The study selected organic agricultural producers under the sustainable agricultural network in Sanam Chai Khet District, Chachoengsao Province. Organic agricultural areas in the study area contributed approximately 1,500 Rai with 130 farmers as sustainable agricultural network members. Data were collected from survey and in-depth interview, and focus group discussion was conducted among selected farmers in major organic agricultural product in sustainable agricultural network to identify the strengths, weaknesses, opportunities, and threats related to organic agricultural farming activities. SWOT Analysis was used to evaluate the internal and external aspects impacting organic agricultural production in the study area from which organic agricultural producer strategies were developed. On the basis of the analysis, the relevant suggestions on facilitating the interests of producers in the supply chain of sustainable agricultural products are improving the technology for production; increasing the agricultural production yield; establishing the promotional strategies to expand production area and members, and improving the quality of organic agricultural products to satisfy the safety quality product standard and consumer needs.
Waveform changes of the first-order multifocal electroretinogram in patients with glaucoma.

PURPOSE To investigate the relationship between the components of the first-order multifocal electroretinogram (M-ERG) and glaucomatous visual field loss. METHODS Twenty-six eyes of 14 patients with primary open-angle glaucoma (POAG) were evaluated with the M-ERG techniques. Twenty-six eyes of 26 normal subjects also were tested as control subjects. To record the M-ERG, a stimulus matrix of 103 scaled hexagonal elements was displayed on a monitor driven at a 75-Hz frame rate according to a binary m-sequence. The M-ERG responses were averaged in each quadrant of the stimulus field and the peak-to-trough amplitudes and peak implicit times of the first trough (N1), the first peak (P1), and the second trough (N2) of the M-ERG were compared with the mean sensitivity values (dB) of the corresponding quadrant of the Humphrey static perimetric field. RESULTS The changes in the peak latencies of P1 and N2 in the POAG group were small but significant compared with those in the normal group (P < 0.01). However, no significant differences in the amplitudes of (P1-N1) and (P1-N2) between the two groups were found. Significant negative correlations between the peak implicit times of N1, P1, and N2 and the mean sensitivity values (dB) of static perimetry were observed. The correlation coefficients were -0.20 (P < 0.05) for the N1, -0.41 (P < 0.001) for the P1, and -0.59 (P < 0.001) for the N2. No significant correlations were observed between the amplitudes (P1-N1 and P1-N2) and the mean sensitivity values. CONCLUSIONS The present study findings suggest that the peak implicit times, but not the amplitudes, of the M-ERG increase as the glaucomatous visual field deteriorates. The amplitudes of the M-ERG did not decrease as the glaucomatous optic nerve dysfunction progressed.
Vendor vs. Client Risks in Outsourced IT Projects: An Agency Theory Perspective

As outsourced and multinational IT projects become more common, managing risks for these projects is increasingly important. The research reported here examined key risks identified by Hong Kong vendor project managers working on both local and international package implementation projects. In addition to the typical risks that threaten project outcome success, respondents noted additional client-side and vendor-side risks, as well as location-specific risks on their multinational projects. They also distinguished threats to the satisfactory process of the project, and threats to their own firms from competitors and from potential damage to their reputation arising from customer dissatisfaction with either the outcomes or the process of the project. This broader risk focus of vendor project managers is contrasted with the client perspective through the lens of agency theory. Traditionally, agency theory has been used to predict risks to the client-principal related to vendors’ profit goals in the outsourcing relationship. However, the findings of this study suggest that vendors’ higher-level concerns for their future business and reputation mitigate the risk to the client of vendor opportunistic behavior.
Nasal venous drainage and the foramen caecum

There has been a general acceptance that veins of the upper nasal region join a vein or veins that pass through the foramen caecum of the frontal bone and establish the most rostral lumen of the superior sagittal sinus. This anastomosis between the extracranial and intracranial venous systems has been presumed to be one avenue of escape for intracranial venous blood following occlusion of the superior sagittal sinus; also, this venous channel has been considered a potential portal of entry for inflammatory disease of the nose into the intracranial cavity. A vein or veins passing through the foramen caecum have not been demonstrable macroscopically in any of 201 specimens of cerebral dural sinuses examined by us.
MYELIN BASIC PROTEIN AND GLIAL FIBRILLARY ACIDIC PROTEIN IN HUMAN FETAL BRAIN*

We demonstrated myelin basic protein (MBP) and glial fibrillary acidic protein (GFAP) in tissue sections of routinely‐processed premature human brain employing the peroxidase‐antiperoxidase (PAP) method. The MBP immunostain delineated oligodendroglia before the appearance of myelin sheaths. The GFAP immunostain indicated that in addition to the stellate astrocyte, bouquet‐shaped glia and radial glia are also astrocytic in nature. The bouquet‐shaped glia may be the normal counterpart for the gemistocytic astrocyte. The glia limitans stained with GFAP beginning with our first specimen. Small numbers of ependymal cells also contained cytoplasmic. GFAP.
Live Donor Liver Transplantation With Older (≥50 Years) Versus Younger (<50 Years) Donors: Does Age Matter?

Objective:To compare the outcome of adult live donor liver transplantation (LDLT) with grafts from older versus younger donors. Introduction:Using older donor grafts for adult LDLT may help expand the donor pool. However, the risks of LDLT with older donors remain controversial, and many centers are reluctant to use live donors aged 45 years or older for adult LDLT. Methods:Outcomes of patients receiving a LDLT graft from donors aged 50 years or older (n = 91) were compared with those receiving a live donor graft from donors younger than 50 years (n = 378). Results:Incidences of biliary (LDLT <50: 24% vs LDLT ≥50: 23%; P = 0.89) and major complications (LDLT <50: 24% vs LDLT ≥50: 24%; P = 1) were similar between both groups of recipients. No difference was observed in 30-day recipient mortality (LDLT <50: 3% vs LDLT ≥50: 0%; P = 0.13). The 1- (90% vs 90%), 5- (82% vs 73%), and 10- (71% vs 58%) year graft survival was statistically similar between both groups (P = 0.075). Likewise, patient survival after 1- (92% vs 96%), 5- (83% vs 79%), and 10- (76% vs 69%) years was also similar (P = 0.686). Overall, donors rate of major complications (Dindo-Clavien ≥3b) within 30 days was low (n = 2.3%) and not different in older versus younger donors (P = 1). Donor median hospital stay in both groups was identical [LDLT <50: 6 (4–17) vs LDLT ≥50: 6 (4–14) days; P = 0.65]. No donor death occurred and all donors had full recovery and returned to baseline activity. Conclusions:Right lobe LDLT with donors aged 50 years or older results in acceptable recipient outcome without increased donor morbidity or mortality. Potential live donors should not be declined on the basis of age alone.
Crafting the self: older persons' narratives of occupational identity.

OBJECTIVE This study aimed to examine how engagement in creative occupations informed six older retired people's occupational identities. METHOD Occupational narratives were gathered from in-depth interviews with 6 participants (75 years of age or older) who had extended experience of participation in creative occupations. A process of narrative-type inquiry produced summarized, chronological stories for each participant. Subsequently, a process of paradigmatic-type narrative analysis produced thematic categories related to how a sense of self is associated with creative occupational engagement in later life. RESULTS Four themes derived from data analysis included the relevance of relational practices, changing self-awareness, enduring qualities, and reflective processes to the formation of a sense of self. CONCLUSION This study adds to an understanding of how leisure occupations maintained across the life cycle contribute to building an occupational identity.
The effect of mobile health service quality on user satisfaction and continual usage

This paper assesses the level of mobile health service quality and its effect on user satisfaction and continual usage among selected maternal healthcare users in rural Ghana. A purposive sampling method is deployed to select 305 respondents. Structural equation modelling technique is used to analyse an mHealth service quality model. Among the three dimensions of mHealth service quality, only interaction quality is significant on user satisfaction while all the three mHealth service quality dimensions were found to have a positive impact on continual usage. A positive effect of satisfaction on continual usage exists and perceived monetary cost moderates the effect. The study suggests that service providers should empower their personnel through the provision of periodic training on good customer relations. This paper contributes to the understanding of service quality issues in mHealth services for maternal healthcare delivery with insights for other sectors.
The Impact of Missing Skills on Learning and Project Performance

To improve the performance of software projects, a number of practices are encouraged that serve to control certain risks in the development process, including the risk of limited competences related to the application domain and system development process. A potential mediating variable between this lack of skill and project performance is the ability of an organization to acquire the essential domain knowledge and technology skills through learning, specifically organizational technology learning. However, the same lack of knowledge that hinders good project performance may also inhibit learning since a base of knowledge is essential in developing new skills and retaining lessons learned. This study examines the relationship between information system personnel skills and domain knowledge, organizational technology learning, and software project performance with a sample of professional software developers. Indications are that the relationship between information systems (IS) personnel skills and project performance is partially mediated by organizational technology learning.
Chapter 13 The Innovation Outcomes of MNC Subsidiaries' Local Embeddedness: Evidence from the German ‘Bioregion Rhein-Neckar-Dreieck’ Local Network

Purpose – This study explores subsidiaries' local network embeddedness and how it contributes to localised subsidiary innovation output from a social network perspective. In particular, we are interested in analysing the consequences of local network density, diversity and, subsidiaries' network position on its innovation outcomes. Design/methodology/approach – Data are derived from a longitudinal quantitative study of the entire R&D network within one of the largest life science cluster in Germany, the ‘BioRegion Rhein-Neckar-Dreieck’. Findings – Our findings indicate that the size (density) of the local network has an inverted U-shaped effect on the innovation outcomes of MNC subsidiaries. Our findings further indicate that a strong brokerage position in the local network has a significant positive influence on the innovation output while a position in the core of the network has a significant negative effect on the innovation output. Research implications – Our results shed new light on the relationship between local embeddedness, brokerage, the danger of overembeddedness and innovation output of MNC subsidiaries.
Downsized FX Markets: Causes and Implications

For the first time in 15 years, FX trading volumes contracted between two consecutive BIS Triennial Surveys. The decline in trading by leveraged institutions and "fast money" traders, and a reduction in risk appetite, have contributed to a significant drop in spot market activity. More active trading of FX derivatives, largely for hedging purposes, has provided a partial offset. Many FX dealer banks have become less willing to warehouse risk and have been re-evaluating their prime brokerage business. At the same time, new technologically driven non-bank players have gained firmer footing as market-makers and liquidity providers. Against this backdrop, FX trading is becoming increasingly relationship-driven, albeit in an electronic form. Such changes in the composition of market participants and their trading patterns may have significant implications for market functioning and FX market liquidity resilience going forward.1
Information technology and regional development : global village or rural backwater?

This paper discusses information and communication technology and regional development. A two region model is adopted to a stylized urban-rural setting and numerical simulations presented. Diffusion of information technology, modeled as a reduction in the cost of transmitting digitized producer services over geographical distances, has a dramatic impact on rural skilled workers’ wages both relative to rural unskilled workers and relative to urban skilled workers. The paper presents a case study of a naval architecture and design company located in rural Norway selling their services all over the world. “After all, the most famous modern agglomeration of industry, Silicon Valley, has occurred in the industry with the most direct access to the latest and best information technology. ” (Gaspar and Glaeser 1998, p. 155)