Miracle-dz/UniFAR-FTUs huggingface dataset:
Depression and suicide attempt as risk factors for incident unprovoked seizures

Major depression has been shown to increase the risk for development of epilepsy, but prior studies have not evaluated whether this is due to specific symptoms of depression. We conducted a population‐based case–control study of all newly diagnosed unprovoked seizures among Icelandic children and adults aged 10 years and older to test the hypothesis that major depression is a risk factor for developing unprovoked seizure and epilepsy, and to address whether specific symptoms of depression account for this increased risk. Cases were matched to the next two same sex births from the population registry. Using standardized interviews, we ascertained symptoms of major depression to make a Diagnostic and Statistical Manual, Fourth Edition (DSM‐IV) diagnosis. A history of major depression was 1.7‐fold more common among cases than among controls (95% confidence interval, 1.1–2.7). A history of attempted suicide was 5.1‐fold more common among cases than among controls (95% confidence interval, 2.2–11.5). Attempted suicide increased seizure risk even after adjusting for age, sex, cumulative alcohol intake, and major depression or number of symptoms of depression. Major depression and attempted suicide independently increase the risk for unprovoked seizure. These data suggest that depression and suicide attempt may be due to different underlying neurochemical pathways, each of which is important in the development of epilepsy. Ann Neurol 2005
The biosynthesis of salicylic acid in potato plants

Spraying potato (Solanum tuberosum L.) leaves with arachidonic acid (AA) at 1500 &mgr;g mL-1 led to a rapid local synthesis of salicylic acid (SA) and accumulation of a SA conjugate, which was shown to be 2-O-beta-glucopyranosylsalicylic acid. Radiolabeling studies with untreated leaves showed that SA was synthesized from phenylalanine and that both cinnamic and benzoic acid were intermediates in the biosynthesis pathway. Using radiolabeled phenylalanine as a precursor, the specific activity of SA was found to be lower when leaves were treated with AA than in control leaves. Similar results were obtained when leaves were fed with the labeled putative intermediates cinnamic acid and benzoic acid. Application of 2-aminoindan-2-phosphonic acid at 40 &mgr;M, an inhibitor of phenylalanine ammonia-lyase, prior to treatment with AA inhibited the local accumulation of SA. When the putative intermediates were applied to leaves in the presence of 2-aminoindan-2-phosphonic acid, about 40% of the expected accumulation of free SA was recovered, but the amount of the conjugate remained constant.
Prenatal diagnosis using cell‐free nucleic acids in maternal body fluids: A decade of progress

The ability to detect cell‐free fetal nucleic acids in pregnant women has greatly evolved over the past decade. Dozens of papers have explored the biology, kinetics, and clinical significance of both cell‐free fetal DNA and mRNA in the maternal circulation. As a result, our overall understanding of fetal nucleic acid trafficking has expanded. To date, two applications, gender determination and fetal RhD status, have translated into clinical medicine. However, with advanced molecular techniques such as mass spectrometry, real‐time quantitative polymerase chain reaction, and gene expression arrays, the ease with which fetal genes can be detected within the mother has greatly improved. Newly identified placental and fetal mRNA transcripts as well as an epigenetically modified placental DNA marker, maspin, have universal applicability. Global expression analyses of fetal mRNA in both amniotic fluid and blood provide new insights into fetal development and pathology. Prenatal diagnosis is poised to evolve from detection of aneuploidy to detection of deviation from normal development, which should provide novel opportunities for fetal treatment. © 2007 Wiley‐Liss, Inc.
伴PNH克隆的获得性再生障碍性贫血临床特征及PNH克隆演变分析

目的 分析伴阵发性睡眠性血红蛋白尿症(PNH)克隆的再生障碍性贫血(AA)患者临床特点，以及PNH克隆大小演变对疗效和生存的影响。 方法 回顾2011年1月至2014年9月间收治的316例诊断明确的AA患者临床资料，分析其临床特点及PNH克隆大小演变对疗效和生存的影响。 结果 ①316例AA患者中90例(28.5%) PNH克隆阳性，有随访资料的83例患者完全缓解(CR) 36例(43.4%)，部分缓解(PR)28例(33.7%)，有效率为77. 1%。 3年及5年总生存(OS)率分别为79. 4％与76. 1%。 ②24例免疫抑制治疗(IST)后PNH克隆转为阳性，PNH克隆持续阳性者22例，PNH克隆消失者10例，三组间有效率、OS率、网织红细胞(Ret)绝对值、总胆红素、间接胆红素、LDH差异均无统计学意义(P值均>0.05)；共10例患者进展为AA-PNH综合征，中位进展时间15. 6个月，有效率及OS率与其他46例患者比较差异无统计学意义(P值分别为0.896、0.688)。 ③单因素分析显示年龄≥55岁、合并感染、极重型AA(VSAA)、中性粒细胞绝对计数(ANC)<0.5×109/L、Ret绝对值<0.012×1012/L为影响患者OS的因素(P值分别为0.026、0.000、0.001、0.000及0.010)；而多因素Cox回归模型分析显示年龄≥ 55岁[RR=2.871(95%CI 0.998~8.263)，P=0.050]、合并感染[RR=2.165 (95%CI 0.064~0.712)，P=0.012]及ANC <0.5×109/L [RR=4.902(95%CI 0.041~1.004)，P=0.050]为影响患者OS的独立预后因素。 单因素及多因素分析均未发现PNH克隆大小与疗效及长期生存的相关性。 结论 PNH克隆的大小及其演变对患者疗效及长期生存无明显影响。
Antenatal betamethasone attenuates the angiotensin-(1-7)-Mas receptor-nitric oxide axis in isolated proximal tubule cells.

We previously reported a sex-specific effect of antenatal treatment with betamethasone (Beta) on sodium (Na+) excretion in adult sheep whereby treated males but not females had an attenuated natriuretic response to angiotensin-(1-7) [Ang-(1-7)]. The present study determined the Na+ uptake and nitric oxide (NO) response to low-dose Ang-(1-7) (1 pM) in renal proximal tubule cells (RPTC) from adult male and female sheep antenatally exposed to Beta or vehicle. Data were expressed as percentage of basal uptake or area under the curve for Na+ or percentage of control for NO. Male Beta RPTC exhibited greater Na+ uptake than male vehicle cells (433 ± 28 vs. 330 ± 26%; P < 0.05); however, Beta exposure had no effect on Na+ uptake in the female cells (255 ± 16 vs. 255 ± 14%; P > 0.05). Ang-(1-7) significantly inhibited Na+ uptake in RPTC from vehicle male (214 ± 11%) and from both vehicle (190 ± 14%) and Beta (209 ± 11%) females but failed to attenuate Na+ uptake in Beta male cells. Beta exposure also abolished stimulation of NO by Ang-(1-7) in male but not female RPTC. Both the Na+ and NO responses to Ang-(1-7) were blocked by Mas receptor antagonist d-Ala7-Ang-(1-7). We conclude that the tubular Ang-(1-7)-Mas-NO pathway is attenuated in males and not females by antenatal Beta exposure. Moreover, since primary cultures of RPTC retain both the sex and Beta-induced phenotype of the adult kidney in vivo they appear to be an appropriate cell model to examine the effects of fetal programming on Na+ handling by the renal tubules.
How Metabolism Generates Signals during Innate Immunity and Inflammation*

The interplay between immunity, inflammation, and metabolic changes is a growing field of research. Toll-like receptors and NOD-like receptors are families of innate immune receptors, and their role in the human immune response is well documented. Exciting new evidence is emerging with regard to their role in the regulation of metabolism and the activation of inflammatory pathways during the progression of metabolic disorders such as type 2 diabetes and atherosclerosis. The proinflammatory cytokine IL-1β appears to play a central role in these disorders. There is also evidence that metabolites such as NAD+ (acting via deacetylases such as SIRT1 and SIRT2) and succinate (which regulates hypoxia-inducible factor 1α) are signals that regulate innate immunity. In addition, the extracellular overproduction of metabolites such as uric acid and cholesterol crystals acts as a signal sensed by NLRP3, leading to the production of IL-1β. These observations cast new light on the role of metabolism during host defense and inflammation.
On Sample Size of the Kruskal–Wallis Test with Application to a Mouse Peritoneal Cavity Study

Summary As the nonparametric generalization of the one‐way analysis of variance model, the Kruskal–Wallis test applies when the goal is to test the difference between multiple samples and the underlying population distributions are nonnormal or unknown. Although the Kruskal–Wallis test has been widely used for data analysis, power and sample size methods for this test have been investigated to a much lesser extent. This article proposes new power and sample size calculation methods for the Kruskal–Wallis test based on the pilot study in either a completely nonparametric model or a semiparametric location model. No assumption is made on the shape of the underlying population distributions. Simulation results show that, in terms of sample size calculation for the Kruskal–Wallis test, the proposed methods are more reliable and preferable to some more traditional methods. A mouse peritoneal cavity study is used to demonstrate the application of the methods.
Molecular genetic variation in the East Midlands, England: analysis of VNTR, STR and Alu insertion/deletion polymorphisms

Background: Short tandem repeats (STRs) and variable number of tandem repeats (VNTRs) have been used successfully in disease analysis and studies of human evolution and population genetic diversity. However DNA-based comprehensive population genetic studies of the East Midlands, England are limited. Subjects and methods: To enlarge our understanding of genetic variation in the East Midlands, a study was conducted on five regional populations: north-west Derbyshire, north-east Derbyshire, south Derbyshire, Nottinghamshire and Leicestershire. Blood samples were collected from donors whose ancestors had lived in the region for at least three generations. Seven VNTRs (MS1 (D1S7), MS31 (D7S21), MS43A (D12S11) and YNH24 (D2S44), D1S80, APOB, YNZ22 (D17S5)), six STRs (HumTHO1, HumVWA31A, HumF13A01, HumFESFPS, HumCSF1PO, HumTPOX) and six Alu insertion/deletion polymorphisms (TPA25, ACE, PV92, F13B, APO, D1) were analysed in approximately 500 individuals. Allele or bin frequencies were calculated using gene counting and fixed bin methods. The chi-square method and exact tests were used to assess Hardy-Weinberg equilibrium. Genetic distances were calculated using Nei's DA method and correspondence analysis was used to assess population affinities. Results: The overall pattern of allele frequencies was similar to many European and UK populations for a number of genetic systems. Overall heterogeneity was observed for five loci: MS43A, MS31, HumF13A01, HumFESFPS and HumTHO1. Twenty-three of 190 pairwise population comparisons were also statistically significant at the 5% level. Average molecular genetic system heterozygosity was 1.5 times higher than observed with conventional blood group systems. GST values for molecular systems were also higher than conventional systems (0.012 vs 0.005) and suggest a low to moderate level of differentiation. Conclusion: The allele frequency spectrum and inter-population comparisons show that there is significant genetic variation in the five contiguous regional populations of the East Midlands. Some of this variation may be due to local geographical barriers, genetic drift and possibly the settlement patterns of Continental European invaders.
Fake News in Social Networks

We model the spread of news as a social learning game on a network. Agents can either endorse or oppose a claim made in a piece of news, which itself may be either true or false. Agents base their decision on a private signal and their neighbors' past actions. Given these inputs, agents follow strategies derived via multi-agent deep reinforcement learning and receive utility from acting in accordance with the veracity of claims. Our framework yields strategies with agent utility close to a theoretical, Bayes optimal benchmark, while remaining flexible to model re-specification. Optimized strategies allow agents to correctly identify most false claims, when all agents receive unbiased private signals. However, an adversary's attempt to spread fake news by targeting a subset of agents with a biased private signal can be successful. Even more so when the adversary has information about agents' network position or private signal. When agents are aware of the presence of an adversary they re-optimize their strategies in the training stage and the adversary's attack is less effective. Hence, exposing agents to the possibility of fake news can be an effective way to curtail the spread of fake news in social networks. Our results also highlight that information about the users' private beliefs and their social network structure can be extremely valuable to adversaries and should be well protected.
Expression of platelet‐derived growth factor in a model of acute liver injury

Platelet‐derived growth factor has been shown to play an important role in the repair process after acute tissue injury and in the pathogenesis of several fibrogenic disorders. The aim of this study was to evaluate whether increased expression of platelet‐derived growth factor and its β‐receptor subunit occurs in a model of acute liver injury. Male Sprague‐Dawley rats were given a single intragastric dose of carbon tetrachloride and killed at intervals of 24, 48 and 72 hr and 1 wk. Control animals were included in each group. Platelet‐derived growth factor‐B chain mRNA expression, analyzed by RNase protection assay, was not detectable in control samples or in samples obtained 24 hr or 1 wk after carbon tetrachloride. However, the presence of protected fragments of 130 kb was clearly detected after 48 hr and was still present, although less abundant, after 72 hr. The distribution of platelet‐derived growth factor protein in liver tissue sections, evaluated by immunohistochemistry, was restricted to centrilobular veins and portal tracts in normal liver. In carbon tetrachloride‐treated rats, prominent staining was observed in areas corresponding to hepatocellular necrosis and inflammatory infiltration. This feature, already present at 24 hr after carbon tetrachloride, became more marked at 48 hr with a gradual resolution after 72 hr. The expression of platelet‐derived growth factor‐receptor β‐subunit mRNA, evaluated by in situ hybridization, was markedly increased after carbon tetrachloride with a peak at 24 hr and was mainly localized over mesenchymal cells in the hepatic sinusoids. The overall analysis of these results suggests that platelet‐derived growth factor may play a positive role in the process of tissue repair after acute liver injury by promoting effective necrotic tissue removal and the reconstruction of an adequate extracellular matrix network. (Hepatology 1994;19:701–707).
STRENGTHENING THE ROLE OF ISLAMIC PAWNSHOP IN ISLAMIC FINANCING FOR MSMES: ANP APPROACH

Objectives: aims to strengthen the role of Islamic pawnshop in financing for Micro Small & Medium Enterprises Methods: analytic network process (ANP) approach Results: the main problem of Islamic pawnshop in expansion was its internal. The most priority was on socialization through promotion and advertisement. The appropriate strategy to be executed was marketing strategy to expand Ar-Rum product (financing for MSMEs) through sales marketing. Conclusion: the considered action was massive socialization to the societies using effective and efficient marketing strategy.
Optimizing the flexibility of a portfolio of generating plants to deal with wind generation

The uncertainties resulting from the integration of a large amount of wind and other stochastic forms of renewable generation affect the reliability of the power system. While it is generally agreed that coping with this uncertainty will require a more flexible system, not enough work has been done to provide dependable estimates of the amount of “flexibility” needed. This paper discusses a technique to determine the optimal amount of flexibility that a generation portfolio should provide for different levels of wind penetration. This optimization must bridge the gap between long-term investment decisions on the type of plants to be built and short-term operational decisions on how these plants are scheduled to meet the load and provide sufficient reserve. To achieve this goal, the unit commitment (UC) problem has been extended to consider not only whether a particular generating unit should be committed at a given time but also whether building this unit would reduce the sum of the operational and investment costs. A proper assessment of the balance between these two costs must take into account the seasonal variations in the load profile and must therefore consider an optimization horizon representative of a year. This paper describes the techniques that have been developed to make such calculations both accurate and achievable with a reasonable amount of computing resources. Test results based on the IEEE RTS system are presented and demonstrate how different amounts of wind generation capacity and reserve requirements affect the need for flexibility.
Multi-criteria optimal pole assignment robust controller design for uncertainty systems using an evolutionary algorithm

This paper presents the synthesis of an optimal robust controller design using the polynomial pole placement technique and multi-criteria optimisation procedure via an evolutionary computation algorithm – differential evolution. The main idea of the design is to provide a reliable fixed-order robust controller structure and an efficient closed-loop performance with a preselected nominally characteristic polynomial. The multi-criteria objective functions have quasi-convex properties that significantly improve convergence and the regularity of the optimal/sub-optimal solution. The fundamental aim of the proposed design is to optimise those quasi-convex functions with fixed closed-loop characteristic polynomials, the properties of which are unrelated and hard to present within formal algebraic frameworks. The objective functions are derived from different closed-loop criteria, such as robustness with metric ∞, time performance indexes, controller structures, stability properties, etc. Finally, the design results from the example verify the efficiency of the controller design and also indicate broader possibilities for different optimisation criteria and control structures.
EXPERIMENTAL EVOLUTION OF RESISTANCE IN BRASSICA RAPA: CORRELATED RESPONSE OF TOLERANCE IN LINES SELECTED FOR GLUCOSINOLATE CONTENT

The evolutionary response of plant populations to selection for increased defense may be constrained by costs of defense. The purpose of this study was to investigate such constraints on the evolution of defense due to a cost of defense manifested as a trade‐off between defense and tolerance. Variation in the response to artificial damage (tolerance) among lines of Brassica rapa that had been artificially selected for foliar glucosinolate content (defense) was examined. Leaf area was removed from replicates of three selection lines (high glucosinolates, control, and low glucosinolates) at three damage levels (0%, 20%, and 60% damage). An external cost of defense would result in a statistically significant selection line by damage treatment interaction, with those selected for high defense expressing less tolerance than those selected for low defense. Damage treatment had a significant overall effect on estimated total fitness, with fitness declining with increasing damage level. Further, selection line also had a significant overall effect on estimated total fitness, with low‐defense selection lines having higher fitness compared to both control and high‐defense selection lines. More importantly, a cost of defense in terms of tolerance was demonstrated by a significant selection line‐by‐damage treatment interaction. This interaction was in the direction to demonstrate a genetic trade‐off between defense and tolerance, with low‐defense selection lines decreasing estimated total fitness in response to damage less than both control and high‐defense selection lines. Variation in tolerance among selection lines was due to the greater ability of low‐defense lines to maintain fruit and seed production despite the presence of damage. In terms of tolerance, this cost of glucosinolate production in B. rapa could constrain the evolution of increased defense and, in so doing, maintain individuals within the population that are poorly defended yet tolerant.
2‐Hydroxypropyl‐β‐cyclodextrin‐modified SLN of paclitaxel for overcoming p‐glycoprotein function in multidrug‐resistant breast cancer cells

Objectives This study aimed to evaluate the potential of solid lipid nanoparticles (SLNs) of paclitaxel (PTX) modified with a 2‐hydroxypropyl‐β‐cyclodextrin system to enhance cellular accumulation of PTX into p‐glycoprotein (p‐gp)‐expressing cells.
Causal relationships between economic policy uncertainty and housing market returns in China and India: evidence from linear and nonlinear panel and time series models

Abstract In this paper, we modify the multivariate nonlinear causality test to be panel nonlinear causality test and we apply these and other existing related tests to examine the causal relationship between growth in economic policy uncertainty (EPU) and real housing returns in China and India using quarterly data from 2003:01 to 2012:04. Both panel linear and nonlinear Granger causality tests suggest the existence of only linear and nonlinear unidirectional causality relationships from growth in EPU to real housing returns in both China and India, and bivariate linear Granger causality tests suggest the existence of only linear unidirectional causality relationship from growth in EPU to real housing returns only in China. However, nonlinear bivariate Granger causality tests conclude the existence of nonlinear bidirectional causality relationships between growth in EPU and real housing returns in both China and India and cross bivariate linear and nonlinear Granger causality tests discover that there is only a linear causality relationship from Indian growth in EPU to Chinese housing returns. The results confirm the relevance of EPU data to better understand and predict the future behaviour of housing market returns in these countries.
Retrospective clinical and radiologic evaluation of nonsurgical endodontic treatment in human immunodeficiency virus (HIV) infection.

PURPOSE This retrospective study evaluated the clinical and radiographic status of nonsurgical endodontic treatment (ET) of anterior and posterior teeth in HIV-seropositive patients. METHODS ET was analyzed in 26 anterior and 34 posterior teeth from 54 consecutive HIV patients (gender ratio 3 Male : 1 Female, mean age 40.2 years, mean CD4 240, CD4<500 in 88%, 12 with AIDS) over a six year period with a minimum of six months follow-up. ET was evaluated as successful, questionable, or failure based upon clinical factors (palpation, mobility, sinus tract, percussion, function, infection/swelling, occlusion, symptoms) and radiographic factors (periodontal ligament space, rarefaction, lamina dura, root resorption, obturation) during post-treatment examinations with a mean follow up of 26 months. RESULTS Clinical evaluation at follow up found ET outcome was successful in 88%, questionable in 10% (tenderness with percussion, mobility, widened ligament), and a failure in 2% (developed lesion after ET). Periapical lesions were present in 37% of cases (mean lesion size 6.2 mm). Following ET, mean lesion size (1.8 mm) had decreased by 71%. Obturation was evaluated as optimal or acceptable in 68%. Radiographic evaluation was considered successful in 80%, no change in 15%, and a failure in 5%. CONCLUSIONS Despite obturation deficiencies and the immunocompromised state of the patients, endodontic therapy has a relatively high degree of success in the majority of HIV/AIDS patients. HIV infection and AIDS should not be considered as a contraindication to endodontic therapy in this patient population.