Miracle-dz/UniFAR-FTUs huggingface dataset:
Modeling the ultra-wideband outdoor channel: Measurements and parameter extraction method

This paper presents results from an outdoor measurement campaign for ultra-wideband channels at gas stations. The results are particularly relevant for "infostations" where large amounts of data are downloaded to a user within a short period of time. We describe the measurement setup and present a novel high-resolution algorithm that allows the identification of the scatterers that give rise to multipath components. As input, the algorithm uses measurements of the transfer function between a single-antenna transmitter and a long uniform linear virtual array as receiver. The size of the array ensures that the incoming waves are spherical, which improves the estimation accuracy of scatterer locations. Insight is given on how these components can be tracked in the impulse response of a spatially varying terminal. We then group the detected scatterers into clusters, and investigate the angular power variations of waves arriving at the receiver from the clusters. This defines the cluster's "radiation pattern. " Using sample measurements we show how obstacles obstruct the line-of-sight component -- a phenomenon commonly referred to as "shadowing. " We compare the measurement data in the shadowing regions (locations of the receiver experiencing shadowing) with the theoretical results predicted by diffraction theory and find a good match between the two.
Angioimmunoblastic T‐cell lymphoma with hyperplastic germinal centres (pattern 1) shows superior survival to patterns 2 and 3: a meta‐analysis of 56 cases

Tan L H C, Tan S Y, Tang T, Lim S T, Tan D, Lim L C, Kam G L S, Loh T P, Tao M & Koay E S C (2012) Histopathology 60, 570–585 Angioimmunoblastic T‐cell lymphoma with hyperplastic germinal centres (pattern 1) shows superior survival to patterns 2 and 3: a meta‐analysis of 56 cases
Identification, cloning, and characterization of a novel rat natural killer receptor, RNKP30: a molecule expressed in liver allografts

Background. As a component of the innate immune system, natural killer (NK) cells may play a significant role in the early events after solid-organ transplantation. Activated NK cells have been shown to infiltrate allografts in transplant models. To better understand NK cells and the role of NK cell receptors in transplantation, we have cloned and begun characterizing a novel rat molecule, rNKp30. Methods. RNKp30 cDNA was cloned by 5′ rapid amplification of cDNA ends polymerase chain reaction (PCR) and reverse transcriptase (RT)-PCR from mononuclear cells infiltrating a rejecting liver allograft. Southern blot analysis was used to determine the rNKp30 gene copy number. RT-PCR and Northern blotting were used to examine rNKp30 RNA expression in NK cells, multiple tissues, and liver grafts. Immunocytochemistry, immunoprecipitation, and Western blot analysis with two anti-rNKp30 polyclonal antibodies, CA680 and CA1071, were performed. Tunicamycin and endoglycosidase treatments determined the extent of rNKp30 glycosylation. Results. RNKp30 is homologous to human and macaque NKp30. It is a single copy gene with five identified single-nucleotide polymorphisms. RNKp30 is expressed by NK cells and is detectable as a single transcript by Northern blot in normal spleen, lymph node, and lung tissues. RNKp30 is a variably N-glycosylated cell surface molecule with a protein backbone of approximately 21 kDa. Elevated transcript expression of rNKp30 is detected in both rejected and spontaneously accepted liver allografts, but not in syngeneic or cyclosporine A-treated allografts. Conclusions. RNKp30 is a glycosylated surface NK cell receptor with limited polymorphism. This putative activation receptor is expressed in liver allografts and may participate in the innate immune response after transplantation.
Relationship Between Cognitive Assessment and Balance Measures in Adolescents Referred for Vestibular Physical Therapy After Concussion

Objective:To examine the relationship between cognitive and balance performance in adolescents with concussion. Design:Retrospective case series. Setting:Tertiary. Patients:Sixty patients. Interventions:Correlation analyses were performed to describe the relationship between symptoms, cognitive measure, and balance measure at the time of initiation of vestibular physical therapy. Main Outcome Measures:Cognitive performance was assessed using the Immediate Post-concussion Assessment and Cognitive Testing (ImPACT). The dizziness and balance function measures included dizziness severity rating, Activities-specific Balance Confidence scale (ABC), Dizziness Handicap Inventory (DHI), Functional Gait Assessment, gait speed, Timed “UP and GO,” Five Times Sit to Stand, and Sensory Organization Test (SOT). To account for multiple comparisons, the False Discovery Rate method was used. Results:Performance measures of balance were significantly correlated with cognitive measures. Greater total symptom scores were related to greater impairment in the ABC and DHI (r = 0.35-0.39, P ⩽ 0.008) and worse performance in condition 2 of the SOT (r = −0.48, P = 0.004). Among the ImPACT composite scores, lower memory scores were correlated with impaired balance performance measures (r = 0.37-0.59, P ⩽ 0.012). Lower visual memory was also correlated with worse ABC scores. Conclusions:The significant relationships reported between the cognitive performance scores and balance measures may reflect that similar levels of functioning exist across domains in individuals with protracted recovery who receive vestibular physical therapy. Clinical Relevance:The weak-to-moderate relationships warrant the continuous use of multiple domains of assessment. A better understanding to the relationships between the domains of functioning after concussion may improve the overall management approach for adolescents with concussion.
Association of Heme Oxygenase 1 with the Restoration of Liver Function after Damage in Murine Malaria by Plasmodium yoelii

ABSTRACT The liver efficiently restores function after damage induced during malarial infection once the parasites are cleared from the blood. However, the molecular events leading to the restoration of liver function after malaria are still obscure. To study this, we developed a suitable model wherein mice infected with Plasmodium yoelii (45% parasitemia) were treated with the antimalarial α/β-arteether to clear parasites from the blood and, subsequently, restoration of liver function was monitored. Liver function tests clearly indicated that complete recovery of liver function occurred after 25 days of parasite clearance. Analyses of proinflammatory gene expression and neutrophil infiltration further indicated that hepatic inflammation, which was induced immediately after parasite clearance from the blood, was gradually reduced. Moreover, the inflammation in the liver after parasite clearance was found to be correlated positively with oxidative stress and hepatocyte apoptosis. We investigated the role of heme oxygenase 1 (HO-1) in the restoration of liver function after malaria because HO-1 normally renders protection against inflammation, oxidative stress, and apoptosis under various pathological conditions. The expression and activity of HO-1 were found to be increased significantly after parasite clearance. We even found that chemical silencing of HO-1 by use of zinc protoporphyrin enhanced inflammation, oxidative stress, hepatocyte apoptosis, and liver injury. In contrast, stimulation of HO-1 by cobalt protoporphyrin alleviated liver inflammation and reduced oxidative stress, hepatocyte apoptosis, and associated tissue injury. Therefore, we propose that selective induction of HO-1 in the liver would be beneficial for the restoration of liver function after parasite clearance.
Camouflage effects following resin infiltration of postorthodontic white-spot lesions in vivo: One-year follow-up.

OBJECTIVE To assess camouflage effects by concealment of postorthodontic white-spot lesions (WSLs) to sound adjacent enamel (SAE) achieved over 12 months with resin infiltration (Icon, DMG, Hamburg, Germany). METHODS Twenty subjects (trial teeth nteeth = 111) who had received resin infiltration treatment of noncavitated postorthodontic WSLs were contacted for a 1-year follow-up assessment of CIE-L*a*b* colors (T12). Color and lightness (CIE-L*a*b*) data for WSLs and SAE were compared to baseline data assessed before infiltration (T0) and those assessed after 6 months (T6), using a spectrophotometer. The target parameter was the difference between the summarized color and lightness values (ΔEWSL/SAE). Intergroup (WSL, SAE) and intertime comparisons (T0 vs T6, T12) were performed using paired t-tests at a significance level of α = 5%. RESULTS Nine subjects (trial teeth nteeth = 49; male/female ratio 5/4; age range 13-19 years) were available at T12. After the highly significant reduction of ΔEWSL/SAE discrepancies between T0 and T6, analysis of 12-month records revealed color and lightness discrepancy of WSL vs SAE that was significantly decreased compared with baseline, indicating an assimilation of WSL color to SAE appearance after infiltration, while an additional reduction of discrepancies between T6 and T12 was not significant. CONCLUSION As color and lightness characteristics of the Icon infiltrant as well as the esthetic camouflage effects achieved by WSL infiltration were not altered significantly or clinically relevant after 12 months, the method of resin infiltration can be recommended for an enduring esthetic improvement of postorthodontic WSL.
Towards understanding the relation between the gas and the attenuation in galaxies at kpc scales

Context. Understanding the relation between the attenuation and the gas is fundamental for interpreting the appearance of galaxies. This can now be done down to a local scale in the local Universe, thanks to the high spatial resolution achievable from the far-ultraviolet (FUV) to the far-infrared (FIR). More importantly, this relation is also crucial for predicting the emission of galaxies. This is essential in semi-analytic models that link dark matter from large cosmological simulations, to the baryonic matter which we can observe directly. Aims. The aim of the present paper is to provide new and more detailed relations at the kpc scale between the gas surface density and the face-on optical depth directly calibrated on galaxies, in order to compute the attenuation not only for semi-analytic models, but also for observational models as new and upcoming radio observatories are able to trace gas ever farther away in the Universe. Methods. We have selected a sample of 4 nearby resolved galaxies and a sample of 27 unresolved galaxies from the Herschel Reference Survey and the Very Nearby Galaxies Survey, for which we have a large set of multi-wavelength data from the FUV to the FIR including metallicity gradients for resolved galaxies, along with radio HI and CO observations. For each pixel in resolved galaxies and for each galaxy in the unresolved sample, we compute the face-on optical depth from the attenuation determined with the CIGALE spectral energy distribution fitting code and an assumed geometry. We determine the gas surface density from HI and CO observations with a metallicity-dependent XCO factor. Results. We provide new, simple-to-use relations to determine the face-on optical depth from the gas surface density, taking the metallicity into account, which proves to be crucial for a proper estimate. The method used to determine the gas surface density or the face-on optical depth has little impact on the relations except for galaxies that have an inclination over 50°. Finally, we provide detailed instructions on how to efficiently compute the attenuation from the gas surface density taking into account possible information on the metallicity. Conclusions. Examination of the influence of these new relations on simulated FUV and IR luminosity functions shows a clear impact compared to older, more-frequently used relations, which in turn could affect the conclusions drawn from studies based on large-scale cosmological simulations.
analysis of CD9, CD32 and p67 signalling: use of degranulated platelets indicates direct involvement of CD9 and p67 in integrin activation

The use of agonist monoclonal antibodies (mAbs) to probe the signalling function of platelet membrane proteins is severely limited by the dependence of the mAb effect on Fc–FcγRII interaction. Furthermore, in addition to its anchoring role, the FcγRII receptor itself generates a stimulation signal resulting in granule secretion. Platelet stimulation by the released granule contents can then further obscure the original activation signal. Here we demonstrate that these problems are largely overcome by the use of platelets which had been degranulated with thrombin prior to stimulation with mAbs. We found that, like intact cells, degranulated platelets could also be activated and induced to aggregate by mAbs against a 67 kD membrane protein (known as PTA1) and CD9, and by crosslinked CD32 (FcγRII). However, the signal generated by crosslinked FcγRII was weak compared with that induced by the other monoclonal antibodies. Thus, by diminishing the FcγRII signal contribution, we have succeeded for the first time to clearly dissect the target antigen signal from that generated by FcγRII. In addition to differences in the degree of aggregation, analysis of the signals generated by each mAb showed differences in Ca2+ fluxes and protein phosphorylation. Moreover, the signals generated by CD9 and PTA1 antigens differed significantly in their sensitivity to PKC inhibition or ADP‐ribosylation of the small GTP‐binding protein rhoA. Despite these differences, the signals initiated by all three antigens converged to a common signalling pathway which included activation of tyrosine kinase(s). The pattern of protein phosphorylation strongly resembled that induced by gpIIb/IIIa‐mediated platelet interaction with macromolecular ligands and by mutual cell contact. The multiple intercellular links formed by mAb would have a similar effect since the Fc‐receptor anchorage required for antigen stimulation is already known to be provided by adjacent cells. The present findings suggest that the function of both CD9 and PTA1 antigens is closely associated with gpIIb/IIIa activation.
Evidences for a Leaky Scanning Mechanism for the Synthesis of the Shorter M23 Protein Isoform of Aquaporin-4

Aquaporin-4 (AQP4) exists as two major isoforms that differ in the length of the N terminus, the shorter AQP4-M23 and the longer AQP4-M1. Both isoforms form tetramers, which can further aggregate in the plasma membrane to form typical orthogonal arrays of particles (OAPs) whose dimension depends on the ratio of the M1 and M23. In this study, we tested the hypothesis that the M23 isoform can be produced directly by the M1 mRNA. In cells transiently transfected with AQP4-M1 coding sequence we observed besides AQP4-M1 the additional presence of the AQP4-M23 isoform associated with the formation of typical OAPs observable by two-dimensional blue native/SDS-PAGE and total internal reflection microscopy. The mutation of the second in-frame methionine M23 in AQP4-M1 (AQP4-M1M23I) prevented the expression of the M23 isoform and the formation of OAPs. We propose “leaky scanning” as a translational mechanism for the expression of AQP4-M23 protein isoform and that the formation of OAPs may occur even in the absence of AQP4-M23 mRNA. This mechanism can have important pathophysiological implications for the cell regulation of the M1/M23 ratio and thus OAP size. In this study we also provide evidence that AQP4-M1 is mobile in the plasma membrane, that it is inserted and not excluded into immobile OAPs, and that it is an important determinant of OAP structure and size.
Quality of life as an outcome measure.

It is important to identify unknown and unquantified benefits and risks of therapeutic intervention that are reflected in the quality of life. This is especially important when the benefit : risk analysis is not clearly in favour of treatment. Quality of life is defined and target areas identified. The steps in the measurements of quality of life are discussed, including the validity, repeatability and sensitivity to change of existing methods; their acceptability, analytical problems; the presentation of the results; and the use of the results in economic evaluations. The Sickness Impact Profile, the Nottingham Health Profile and the Quality of Well-Being scale are compared for the assessment of patients with angina. The advantages and disadvantages of each is discussed together with the results from a double-blind trial of treatment in angina where the Sickness Impact Profile was employed. Generic and disease-specific instruments are compared. The advantages and disadvantages of economic evaluations employing quality-of-life outcomes are discussed. Methods should be employed that withstand rigorous scientific evaluation. Both a health profile and a summary statistic such as a Health Status Index should be measured. If different treatments are to be compared, a randomised controlled trial should be employed. If the more expensive treatment is likely to be superior then costs should be collected and a cost-utility analysis performed.
Hematological Profile of Sudanese Patients with Systemic Lupus Erythematosus

This is a case control study aimed to evaluate hematological status of Sudanese female patients with Systemic Lupus Erythematous. The objective off the study is to assess hematological profile of Sudanese patients with Systemic Lupus Erythematosus. Fifty SLE patients and 50 apparently healthy females were enrolled in the study. Age of participants ranged from 18 to 62 years with 64% with age less than 40 years. Hb was 11.2 ± 1.9 g/dl compared to 12.7 ± 1.1 g/dl in control group (p = 0.000). RBC and PCV significantly decreased (p = 0.000, 0.003) respectively. Neutrophils count was 4.1 ± 2.1× 10 3 μl compared to 3.0 ± 1.1× 10 3 μl in control group. Anemia and infection are frequent among SLE patients. Thrombocytes remained within normal range. In conclusion, most common age of SLE patients ranged between 18 and 40 years.
A comparison of Australian and Malaysian views on the use of biometric devices in everyday situations

Since the September 11, 2001 terrorist attacks in New York City, many countries including Australia and Malaysia have been able to justify the use biometric devices such as finger print scans, retina scans and facial recognition for identification and surveillance of its citizens and others in the name of national security. In addition, biometric devices are increasingly being used worldwide by organizations to keep track of their employees and their productivity, leading to concerns of privacy, the safety, reliability, abuse and misuse of the data collected and violations of civil liberties. Taking the critical theory perspective, this paper will analyse the data collected and report on the findings of a survey carried out in Australia and Malaysia, with respect to the responses provided and opinions expressed to the survey s open ended and other questions by individuals as to their current use, experiences, preferences, concerns about the devices and the situations in which they think biometric devices should be used, including in their workplaces. This descriptive study uses both quantitative and qualitative data to examine what Australians and Malaysians think about the use of biometric devices in everyday situtions and compare them as to their similarities and differences. The paper will then critically examine the ethical and civil liberties issues involved in the use of biometric devices in everyday life and argues that regulatory and legal measures should be taken to safeguard the rights of citizens while maintaining national security and productivity, in order to avoid the situation of Michel Foucaults Panopticon becoming an unpleasant everyday reality, which could negatively irifluence socialjustice and create social change due to its effects on individuals in two multicultural societies. The paper will argue about the need to educate the general public as to the issues of surveillance and privacy involved in the use of biometric devices in everyday situations.
Evaluation of Pharmaceuticals With a Novel 50‐Hour Animal Model of Bone Loss

Osteoporosis remains a major public health problem through its associated fragility fractures. Several animal models for the study of osteoporotic bone loss, such as ovariectomy (OVX) and denervation, require surgical skills and several weeks to establish. Osteoclast differentiation and activation is mediated by RANKL. Here we report the establishment of a novel and rapid bone loss model by the administration of soluble RANKL (sRANKL) to mice. Mice were injected intraperitoneally with sRANKL and used to evaluate existing anti‐osteoporosis drugs. sRANKL decreased BMD within 50 h in a dose‐dependent manner. The marked decrease in femoral trabecular BMD shown by pQCT and the 3D images obtained by μCT were indistinguishable from those observed in the OVX model. Histomorphometry showed that osteoclastic activity was significantly increased in the sRANKL‐injected mice. In addition, serum biochemical markers of bone turnover such as Ca, C‐telopeptide of type 1 collagen (CTX), and TRACP5b were also significantly increased in the sRANKL‐injected mice in a dose‐dependent manner. Bisphosphonates (BPs), selective estrogen receptor modulators (SERMs), and PTH are commonly used for the treatment of osteoporosis. We successfully evaluated the effects of anti–bone‐resorbing agents such as BPs, a SERM, and anti–RANKL‐neutralizing antibody on bone resorption in a couple of weeks. We also evaluated the effects of PTH on bone formation in 2 wk. A combination of sRANKL injections and OVX made it possible to evaluate a SERM. The sRANKL model is the simplest, fastest, and easiest of all osteoporosis models and could be useful in the evaluation of drug candidates for osteoporosis.
Bayesian Preference Elicitation for Multiobjective Engineering Design Optimization

Many engineering optimization problems have more than one objective. Although there are methods for identifying the Pareto front of a design space, these methods can be computationally prohibitive, and it is still left to the designer to choose which design on the front to build. Consequently, multiobjective optimization often involves specifying a scalar utility function and then optimizing with respect to this utility function. Preference elicitation algorithms can aid the designer in constructing this utility function. In preference elicitation for engineering design optimization, the ideal algorithm would converge to an accurate utility function with as few preference queries to the designer as possible. This paper extends a prior method for preference realization and tailors it for use in engineering design optimization by deriving a less restrictive inference technique and applying an entropy-based method for posing queries that converges faster to the true global utility function than existing algo.
A 50-mW, 386 GHz/mm2 wideband amplifier in 0.13-µm CMOS technology

A wideband amplifier with low power consumption (50 mW) and small chip size (0.44 mm2) is demonstrated in a 0.13 µm CMOS technology. A power gain of 9.5 dB is measured with a 3 dB bandwidth covering from 0.1 GHz to 57 GHz as well as a gain-bandwidth-product (GBW) of 170 GHz. The proposed wideband amplifier has distinguished itself with the state-of-the-art performance of GBW/Pdiss (3.4 GHz/mW) and GBW/chiparea (386 GHz/mm2) [1–4], [6–7] which reveals its ability in accomplishing a wideband amplification with reasonable power and area consumptions.