Miracle-dz/UniFAR-FTUs huggingface dataset:
SIRT1 Expression is Associated With Poor Prognosis of Diffuse Large B-Cell Lymphoma

Sirtuin1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent deacetylase. Recently, it is suggested that SIRT1 may be involved in the development of malignant tumors including mouse lymphoma. Therefore, we investigated the prevalence and the prognostic impact of SIRT1 expression in diffuse large B-cell lymphoma (DLBCL). Immunohistochemical expression of SIRT1, p53, bcl2, CD10, bcl6, and multiple myeloma-1 (MUM1) were evaluated by using a 2 mm core from 104 DLBCL patients for tissue microarray. Positive expression of SIRT1 was seen in 74% (77/104) of patients. In total DLBCL patients, SIRT1 and p53 expression were significantly associated with shorter overall survival (OS) by univariate analysis (P=0.001 and P=0.011, respectively). SIRT1 was also an independent prognostic factor by multivariate analysis (P=0.01). According to the expression patterns of CD10, bcl6, and MUM1, germinal center B cell (GCB) types were represented in 38 cases (37%) and non-GCB types were represented in 66 cases (63%). In the GCB type, only p53 expression was associated with a significantly shorter OS (P=0.032). In the non-GCB type, expression of SIRT1 correlated with shorter OS by univariate analyses (P=0.005) and multivariate analyses (P=0.049). In conclusion, we showed that SIRT1 expression is a clinically significant prognostic indicator for DLBCL patients.
Applying the Big Five Personality Factors to the Impostor Phenomenon

The purpose of this study was to relate the impostor phenomenon (IP) to the Five-factor model of personality. A sample of 190 college students (79 men, 111 women) completed the Clance Impostor Phenomenon Scale (Clance, 1985), the Perceived Fradulence Scale (Kolligian & Sternberg, 1991), and the NEO-Personality Inventory-Revised (Costa & McCrae, 1992). Results of correlational and regression analyses support the predicted relations of imposter measures with high Neuroticism and low Conscientiousness. Facet-level correlations showed that depression and anxiety were particularly important characteristics of those with imposter feelings as well as low self-discipline and perceived competence. Implications for treatment and future research on the IP are discussed.
New Evidence on Real Wage Cyclicality Within Employer-employee Matches

In the most thorough study to date on wage cyclicality among job stayers, Devereux's (2001) analysis of men in the Panel Study of Income Dynamics (PSID) produced two puzzling findings: (1) the real wages of salaried workers are noncyclical, and (2) wage cyclicality among hourly workers differs between two alternative wage measures. We examine these puzzles with additional evidence from other sources. Devereux's finding of noncyclical real wages among salaried job stayers is not replicated in the National Longitudinal Survey of Youth (NLSY) data. The NLSY data, however, do corroborate his finding of a discrepancy for hourly workers between the cyclicality of the two alternative wage measures. Evidence from the PSID Validation Study contradicts Devereux's conjecture that the discrepancy might be due to a procyclical bias from measurement error in average hourly earnings. Evidence from the Bureau of Labor Statistics establishment survey supports his hypothesis that overtime work accounts for part (but not all) of the discrepancy. We conclude that job stayers' real average hourly earnings are substantially procyclical and that an important portion of that procyclicality probably is due to compensation beyond base wages.
Comparison of Measures of Visual Acuity in Infants: Teller Acuity Cards and Sweep Visual Evoked Potentials

Purpose: This study compares the development of acuity in the same infants during one testing session using Teller acuity cards (TAC) and sweep visual evoked potentials (sVEP). We asked whether different testing methods in two centers would produce different developmental time courses. Methods: Forty-eight infants were tested in two centers. The standard procedure for TAC was used. For sVEP acuity, the amplitude response curve derived from time-locked cortical activity was used to extrapolate to zero response, giving an acuity estimate for each infant. Results: sVJEP acuity was generally higher than TAC acuity. The rate of development was steeper for TAC than sVEP acuity with TAC starting at a much lower level. The ratio of sVEP to TAC acuity decreased exponentially with age reaching an asymptote of about 1.44 at 6 months. Conclusions: Results were indistinguishable between centers suggesting that comparison of acuity measures obtained using variations of these methods across centers is possible.
Outcome assessment and clinical improvement in panic disorder: evidence from a randomized controlled trial of fluoxetine and placebo. The Fluoxetine Panic Disorder Study Group.

OBJECTIVE Although panic attacks account for only a portion of the morbidity of panic disorder and panic attack frequency assessments are unreliable, studies of drug efficacy in panic disorder have generally used reduction in panic attack frequency as the primary measure of improvement. The authors studied the efficacy of fluoxetine treatment in panic disorder and measured the relative contributions of changes in symptoms to overall improvement. METHOD Patients with a diagnosis of panic disorder (N = 243) were randomly assigned to treatment with 10 or 20 mg/day of fluoxetine or placebo. Primary outcome measures were change in panic attack frequency and clinician-rated Clinical Global Impression improvement scores. Other assessments included a panic attack inventory, clinician-rated and patient-rated versions of the Panic and Phobic Disorder Change Scale, a phobia rating scale, the Hamilton Anxiety Rating Scale, the 21-item Hamilton Depression Rating Scale, and the Sheehan Disability Scale. Correlations were determined between outcomes in individual symptom domains and overall clinical outcome. RESULTS Fluoxetine, particularly the 20-mg/day dose, was associated with more improvement than was placebo in patients with panic disorder across multiple symptom measures, including global improvement, total panic attack frequency, phobic symptoms, and functional impairment. Global improvement was most highly correlated with reductions in overall anxiety and phobic symptoms and least correlated with reduction in panic attacks. Fluoxetine treatment for panic disorder was well tolerated, with a safety profile consistent with that observed for fluoxetine in other disorders. CONCLUSIONS These data provide support for the efficacy and safety of fluoxetine treatment in reducing panic attacks, phobic symptoms, anxiety, and depressive symptoms in patients with panic disorder. Reductions in panic attack frequency in subjects given either fluoxetine or placebo were less closely related to overall clinical improvement than reductions in phobic avoidance, anxiety, depressive symptoms, and functional impairment, suggesting that outcome measures in this disorder should be more broadly based.
Environmental impacts and costs of solid waste: a comparison of landfill and incineration

The methodology for evaluating the impacts and damage costs (`external costs') due to pollution from waste treatment is described and the results are presented, based on the ExternE project series of the European Commission. The damage costs of landfill and incineration of municipal solid waste are compared, with due account for energy and materials recovery, as well as possible differences in transport distance. We have not been able to quantify the total damage costs of leachates because of the complexity of the environmental pathways and of the long time horizon of some persistent pollutants, but we consider an extreme scenario to show that they are not worth worrying about in the sense that reducing the pollutants in leachates beyond current regulations would bring negligible benefit in comparison with the abatement of other sources of the same pollutants. The damage costs due to the construction of the waste treatment facility are negligible. The damage costs of waste transport, which are illustrated by an arbitrary choice of a 100 km round trip by a 16 tonne truck, are also negligible. The benefits of materials recovery make a small contribution to the total damage cost. The only significant contributions come from direct emissions (of the landfill or incinerator) and from avoided emissions due to energy recovery (from an incinerator). Damage costs for incineration range from about 4 to 21 tonnewaste —1, and they are extremely dependent on the assumed scenario for energy recovery. For landfill the cost ranges from about 10 to 13 tonnewaste —1 ; it is dominated by greenhouse gas emissions because only a fraction of the CH4 can be captured (here assumed to be 70%). Amenity costs (odour, visual impact, noise) are highly site-specific and we only cite results from a literature survey which indicates that such costs could make a significant contribution, very roughly on the order of 1 tonnewaste —1.
Abdominal obesity and physical inactivity are associated with erectile dysfunction independent of body mass index.

INTRODUCTION Erectile dysfunction (ED) is common among men with an elevated body mass index (BMI). However, a high waist circumference (WC) and low levels of physical activity may predict ED independently of BMI. AIM We investigated the independent relationships between BMI, WC, and physical activity with ED. METHODS Subjects consisted of 3,941 adult men (age > or = 20 years) with no history of prostate cancer from the 2001-2004 National Health and Nutrition Examination Survey. Logistic regression analyses were used to examine the relative odds of ED association with categories of BMI, WC, and physical activity. MAIN OUTCOME MEASURES Established thresholds were used to divide subjects into three WC and BMI categories. Physical activity level was divided into active (> or =150 min/week), moderately active (30-149 min/week), and inactive (<30 min/week) categories. A single survey question was used to assess the presence of ED. RESULTS After control for potential confounders, men with either a high WC or an obese BMI had an approximately 50% higher odds of having ED compared with men with a low WC or a normal BMI, respectively. Further, moderately active or inactive men had an approximately 40-60% greater odds of ED compared with active men. When all three predictors (WC, BMI, and physical activity level) were entered into the same logistic regression model, both a high WC and low physical activity level (moderately active and inactive) were independently associated with a greater odds of ED, whereas BMI level was not. CONCLUSION Maintaining a WC level below 102 cm and achieving the recommended amount of moderate-intensity physical activity (>or =150 min/week) is associated with the maintenance of proper erectile function, regardless of BMI level. These findings suggest that the clinical screening for ED risk should include the assessment of WC and physical activity level in addition to BMI.
Sibling Bereavement and Continuing Bonds

Historically, from a Freudian and medical model perspective, emotional disengagement from the deceased was seen as essential to the successful adaptation of bereavement. A major shift in the bereavement literature has occurred and it is now generally accepted that despite the permanence of physical separation, the bereaved remains involved and connected to the deceased and can be emotionally sustained through continuing bonds. The majority of literature has focused on adults and on the nature of continuing bonds following the death of a spouse. In this article, the authors demonstrate how the continuing bonds concept applies to the sibling relationship. We describe the unique continued relationship formed by bereaved children and adolescents following a sibling loss, highlight the factors that influence the siblings continuing bonds expressions, and offer clinical interventions. In our view, mental health professionals can play an important role in helping parents encourage activities that may facilitate the creation and maintenance of continuing bonds in their children.
CONSUMER BEHAVIOUR DURING ONLINE GROCERY SHOPPING

Today consumers can buy almost any product using the Internet. Online nutritional and grocery shopping is becoming increasingly popular. The aim of this paper is to present the conditions of online grocery shopping and consumers’ attitude towards buying food via the Internet based. The assessment is based on secondary information sources. With online grocery supermarkets there are no limitations connected with localization and opening hours, and consumers have access to a large range of stores and products online across the world. The most important advantages of online shopping are convenience and time saving, while the most significant disadvantages for consumers involve the risk of incorrectly valuating some products and apprehension about the selection and handling of perishables, such as vegetables, eggs, and meat products.
A Minskyan criticism on the shareholder pressure approach of financialisation

In this paper, the Post-Kaleckian approach on financialisation which argues that investment of Nonfinancial Corporations in real capital assets has been restricted by the rising dividend and interest payments due to shareholder pressure will be criticized based on a Minskyan understanding of investment. It will be put forward that, reinvestment of profits in capital assets has decreased because of declined quasi-rent expectations induced by depressed demand.
Fast coherent integration for migrating targets with velocity ambiguity

In wideband radar, fast moving targets migrate through range gate during the coherent processing interval. To preserve coherent integration gain, range gate walk has to be taken into account. In this paper, we propose a fast algorithm based on a Keystone-like transform that allows one to perform such an integration in case of velocity ambiguous radar.
Research on the Connections Between Corporate Social Responsibility and Corporation Image in the Risk Society: Take the Mobile Telecommunication Industry as an Example

Technological developments and globalization have led to scientific controversies associated with advanced technologies, and increased risk of ecological damage. The uncertainty factors of “risk society” have increased the complexity of modern life. Numerous sources of uncertainty are unidentifiable to the public. Corporate Social Responsibility (CSR) refers to the task of reducing the uncertainty. In a risk society, CSR is a stabilizing force, preventing the occurrence and expansion of risk. The main purpose of this research is to discuss the relationship between corporate social responsibility (CSR)and corporate image in the risk society, especially the electromagnetic fields that are produced by the mobile telecommunications industry. Whereas modern people are blessed by the convenience of mobile telecommunication, they also take the risks associated with exposure to electromagnetic fields. If corporations do not meet their social responsibility, then the effects of such exposure may have irreparable consequences. As well as posing a threat to mobile ‘phone users, the effects of electromagnetic fields can undermine the corporate image. Ulrich Beck called this effect “the boomerang effect. ” If corporations do not act responsibly and to maintain their image, then the social and capital costs incurred will be great when the risks have evolved to crises. This study probes the relationship between CSR and corporate image. Risk society here, is taken as the moderator and to further examine the correlations between CSR and Corporate Image. The results show that perceptions of risk in the context of corporate social responsibility (CSR) and corporate product image (CPI) lead to expectations that are the opposite of the results presented in this investigation: when the degree of perceived risk is higher, CSR has a more positive effect on CPI.
Glucose metabolism and serotonin receptors in the frontotemporal lobe degeneration

In patients with the frontal variant of frontotemporal lobar degeneration (fv‐FTLD), behavioral abnormalities may vary from apathy with motor slowness (apathetic form) to disinhibition with agitation (disinhibited form). These clinical presentations may be related to specific regional cerebral dysfunction and to deficit in the serotoninergic system. We studied cerebral glucose uptake using 18F‐fluorodeoxyglucose and positron emission tomography in 18 patients fulfilling clinical criteria for fv‐FTLD and showing, respectively, an apathetic or disinhibited behavioral syndrome. In eight of these patients, we also evaluated the 5‐hydroxytryptamine‐2A receptor cerebral receptor distribution with [11C]MDL and positron emission tomography. We found a reduction of frontal glucose metabolism in the whole group of fv‐FTLD patients. Apathetic syndrome was associated with a prevalent dorsolateral and frontal medial hypometabolism, whereas the disinhibited syndrome demonstrated a selective hypometabolism in interconnected limbic structures (the cingulate cortex, hippocampus/amygdala, and accumbens nucleus). The in vivo measurements of [11C]MDL indicated a significant reduction of 5‐hydroxytryptamine‐2A receptors in orbitofrontal, frontal medial, and cingulate cortices. These 18F‐fluorodeoxyglucose positron emission tomography changes can be considered as specific functional markers of the different behavioral presentations in fv‐FTLD. The serotoninergic system dysfunction provides a rationale for therapeutic trials with selective serotonin reuptake inhibitors. Ann Neurol 2005;57:216–225
Modding to the Big Leagues: Exploring the Space between Modders and the Game Industry

Modding is an important characteristic of participatory culture in video games. Studies have shown that PC game modders mod for a host of reasons not least of which as a means of developing the skills and portfolio needed to get a job in the video game industry. Modding culture can be thought of as a point of articulation between the industry and participatory cultural practices. Modding culture is not only concerned with accessing the game industry however, but also puts a high premium on modding for fun or out of love for a particular community or game. Because it effectively straddles market and non-market interests it is important to study how modders negotiate the two sides of modding, which has been at the leading edge of the participatory turn in media consumption and production. This article undertakes an evaluation of modding discourses, first through an evaluation of surveys taken by moderators of modding discussion forums and secondly through an evaluation of discussions regarding technologies used by modders. The article sheds light on the complex ways in which modders' understand the practice of modding. It is framed broadly within political economic theories that have attempted to map modding in post-industrial logics and within theories that have understood it as a participatory culture. Ultimately this paper discusses other participatory practices, drawing parallels with modding and venturing some observations about user participation in the new media environment.
Effect of phacoemulsification on intraocular pressure in patients with primary open angle glaucoma and pseudoexfoliation glaucoma.

AIM To compare the effect of phacoemulsification on intraocular pressure (IOP) in patients with primary open angle glaucoma (POAG) and pseudoexfoliation glaucoma (PXG). METHODS A retrospective comparative case series conducted at the Glaucoma Department at the Association to Prevent Blindness in Mexico. The study enrolled consecutive patients having phacoemulsification with intraocular lens (IOL) implantation and a diagnosis of POAG or PXG. Data about IOP values and number of glaucoma medications used was collected at baseline, 1, 3, 6 and 12mo postoperatively. RESULTS The study enrolled 88 patients (88 eyes). After phacoemulsification, there was a statistically significant reduction in IOP values and glaucoma medications use compared to baseline in both POAG and PXG patients (P<0.001). In the POAG group, a 20% decrease in IOP values was evidenced, and a 56.5% reduction in the number of medications used at the one-year follow-up. The PXG group showed a 20.39%, and a 34.46% decrease in IOP and number of medications used, respectively. A significant difference in the mean ΔIOP (postoperative changes in IOP) was evidenced between groups (P=0.005). The reduction of the postsurgical IOP mean values in both groups, the POAG group showed a greater reduction in IOP values compared to the PXG group. CONCLUSION In both types of glaucoma, phacoemulsification cataract surgery can result in a significant IOP reduction (20%) over a 12mo follow-up period. The number of medications used is also significantly reduced up to 12mo after surgery, especially in the PXG group.
A Spiking Neural Network Model of the Lateral Geniculate Nucleus on the SpiNNaker Machine

We present a spiking neural network model of the thalamic Lateral Geniculate Nucleus (LGN) developed on SpiNNaker, which is a state-of-the-art digital neuromorphic hardware built with very-low-power ARM processors. The parallel, event-based data processing in SpiNNaker makes it viable for building massively parallel neuro-computational frameworks. The LGN model has 140 neurons representing a “basic building block” for larger modular architectures. The motivation of this work is to simulate biologically plausible LGN dynamics on SpiNNaker. Synaptic layout of the model is consistent with biology. The model response is validated with existing literature reporting entrainment in steady state visually evoked potentials (SSVEP)—brain oscillations corresponding to periodic visual stimuli recorded via electroencephalography (EEG). Periodic stimulus to the model is provided by: a synthetic spike-train with inter-spike-intervals in the range 10–50 Hz at a resolution of 1 Hz; and spike-train output from a state-of-the-art electronic retina subjected to a light emitting diode flashing at 10, 20, and 40 Hz, simulating real-world visual stimulus to the model. The resolution of simulation is 0.1 ms to ensure solution accuracy for the underlying differential equations defining Izhikevichs neuron model. Under this constraint, 1 s of model simulation time is executed in 10 s real time on SpiNNaker; this is because simulations on SpiNNaker work in real time for time-steps dt ⩾ 1 ms. The model output shows entrainment with both sets of input and contains harmonic components of the fundamental frequency. However, suppressing the feed-forward inhibition in the circuit produces subharmonics within the gamma band (>30 Hz) implying a reduced information transmission fidelity. These model predictions agree with recent lumped-parameter computational model-based predictions, using conventional computers. Scalability of the framework is demonstrated by a multi-node architecture consisting of three “nodes,” where each node is the “basic building block” LGN model. This 420 neuron model is tested with synthetic periodic stimulus at 10 Hz to all the nodes. The model output is the average of the outputs from all nodes, and conforms to the above-mentioned predictions of each node. Power consumption for model simulation on SpiNNaker is ≪1 W.