Miracle-dz/UniFAR-FTUs huggingface dataset:
Validity and completeness of rheumatoid arthritis diagnoses in the nationwide DANBIO clinical register and the Danish National Patient Registry

Objectives In Denmark, patients with rheumatoid arthritis (RA) are registered in the nationwide clinical DANBIO quality register and the Danish National Patient Registry (DNPR). The aim was to study the validity of the RA diagnosis and to estimate the completeness of relevant RA cases in each registry. Study design and setting Patients registered for the first time in 2011 with a diagnosis of RA were identified in DANBIO and DNPR in January 2013. For DNPR, filters were applied to reduce false-positive cases. The diagnosis was verified by a review of patient records. We calculated the positive predictive values (PPVs) of the RA diagnosis registrations in DANBIO and DNPR, and estimated the registry completeness of relevant RA cases for both DANBIO and DNPR. Updated data from 2011 to 2015 from DANBIO were retrieved to identify patients with delayed registration, and the registry completeness and PPV was recalculated. Results We identified 1,678 unique patients in DANBIO or in DNPR. The PPV (2013 dataset) was 92% in DANBIO and 79% in DNPR. PPV for DANBIO on the 2015 update was 96%. The registry completeness of relevant RA cases was 43% in DANBIO, increasing to 91% in the 2015 update and 90% in DNPR. Conclusion DANBIO held a high proportion of true RA cases (96%) and was found to be superior to the DNPR (79%) with regard to the validity of the diagnosis. Both registries were estimated to have a high completeness of RA cases treated in hospital care (~90%).
Identifying Primordial Substructure in NGC 2264

We present new Spitzer Space Telescope observations of the young cluster NGC 2264. Observations at 24 μm with the Multiband Imaging Photometer have enabled us to identify the most highly embedded and youngest objects in NGC 2264. This Letter reports on one particular region of NGC 2264 where bright 24 μm sources are spatially configured in curious linear structures with quasi-uniform separations. The majority of these sources (~60%) are found to be protostellar in nature, with Class I spectral energy distributions. Comparison of their spatial distribution with submillimeter data from Wolf-Chase et al. and millimeter data from Peretto et al. shows a close correlation between the dust filaments and the linear spatial configurations of the protostars, indicating that star formation is occurring primarily within dense, dusty filaments. Finally, the quasi-uniform separations of the protostars are found to be comparable in magnitude to the expected Jeans length, suggesting thermal fragmentation of the dense filamentary material.
Serological confirmation of Brucella abortus and Yersinia enterocolitica O:9 O-antigens by monoclonal antibodies

Murine monoclonal antibodies that bind the O-antigens of Yersinia enterocolitica serotype O:9 and Brucella abortus 1119-3 were generated after immunization of BALB/c mice with killed, whole cells. Highly purified lipopolysaccharide preparations from each organism were used to screen for antigen-specific antibodies. Immunization with B. abortus cells induced 56 antigen-specific hybrids, and 10 of the highest antibody-producing clones were selected for further study. Seven of these clones secreted immunoglobulin G, and three secreted immunoglobulin M antibodies. Immunization with Y. enterocolitica cells resulted after fusion in 76 antigen-specific hybrid cell lines; from these, seven immunoglobulin G-secreting clones were selected for study. The serological cross-reactivity of the B. abortus and Y. enterocolitica O-antigens was established by enzyme-linked immunosorbent assay, immunoprecipitation, and agglutination tests with the monoclonal antibodies induced by each bacterium. This serological cross-reactivity is consistent with the structural identity of the two O-antigens established by chemical analysis.
Submucosal glands after maxillary sinus surgery. An experimental study in rabbits

Abstract Thirty New Zealand White rabbits underwent unilateral partial or complete removal of maxillary sinus mucosa in order to evaluate submucosal maxillary sinus glands. After three months, specimens were taken for examination from all operated on and control sinuses. Bacteriological cultures, light and electron microscopy were performed. Histopathological findings showed a decrease in the number of serous glands and significant inflammation was present in the sinus in which there was complete surgical removal. Electron microscopy revealed changes in the secretory cells of the serous glands in the regenerated postsurgical mucosa.
Seroprevalencia de Ehrlichia canis y su relación con algunos parámetros clínicos y hematológicos en caninos admitidos en clínicas veterinarias de la ciudad de Ibagué (Colombia)

La ehrlichiosis canina es una enfermedad de distribucion mundial, trasmitida por una rickettsia intracelular obligada, denominada Ehrlichia canis y propagada por la garrapata Rhipicephalus sanguineus. Esta enfermedad causa multiples manifestaciones clinicas en los animales sintomaticos y su diagnostico puede ser un desafio para el clinico. Con el fin de determinar la seroprevalencia y los hallazgos clinicos y hematologicos asociados a la presencia Ehrlichia canis en pacientes caninos de la ciudad de Ibague, Tolima (Colombia), fueron evaluados 398 caninos provenientes de diferentes clinicas veterinarias de esta ciudad. Los perros fueron examinados clinicamente y muestreados para la identificacion serologica de anticuerpos para E. canis, empleando un test de inmunofluorecencia indirecta (IFI). Se observo una seroprevalencia del 31,66% (126/398). Los principales hallazgos clinicos encontrados en los animales seropositivos fueron esplenomegalia 4,8% (6/126) y fiebre 4,0% (5/126). No se evidencio asociacion significativa con relacion al sexo, raza, grupo etareo o valores hematologicos. Se concluye que la existencia de sero-reactividad a E. canis en la ciudad de Ibague supone un riesgo de enfermedad clinica en los caninos domesticos y su presencia podria estar asociada a hemoparasitos coexistentes.
Organizational Culture, Job Satisfaction, and Clinician Turnover in Primary Care

The purpose of this study is to examine how organizational culture and job satisfaction affect clinician turnover in primary care pediatric practices. One hundred thirty clinicians from 36 primary care pediatric practices completed the Primary Care Organizational Questionnaire (PCOQ), which evaluates interactions among members of the practice and job-related attributes measuring 8 organizational factors, along with a separate 3-item instrument measuring job satisfaction. Random effects logistic models were used to assess the associations between job satisfaction, the organizational factors from the PCOQ, and clinician turnover over the subsequent year. All 8 measured organizational factors from the PCOQ, particularly perceived effectiveness, were associated with job satisfaction. Five of the 8 organizational factors were also associated with clinician turnover. The effects of the organizational factors on turnover were substantially reduced in a model that included job satisfaction; only 1 organizational factor, communication between clinicians and nonclinicians, remained significant (P = .05). This suggests that organizational culture affects subsequent clinician turnover primarily through its effect on job satisfaction. Organizational culture, in particular perceived effectiveness and communication, affects job satisfaction, which in turn affects clinician turnover in primary care pediatric practices. Strategies to improve job satisfaction through changes in organizational culture could potentially reduce clinician turnover.
Factors Associated with Helplessness among Japanese Collegiate Swimmers

In this study the factors that lead to learned helplessness among Japanese collegiate swimmers were examined. Participants were 135 men and 72 women swimmers (ages 18 to 22 years). A Sports Attributional Style Scale measuring helplessness in performance and daily life was administered, and the participants were divided into two groups: those scoring high and low. Analysis indicated that (1) there was no significant correlation between helplessness scores and performance. (2) The group scoring high on learned helplessness reported a strong tendency towards helplessness not only in competitive life but also in daily life, which implied the generalization of helplessness. (3) The tendency to helplessness in performance was more closely related to the attributional style of positive events than negative events. In conclusion, some factors involved in helplessness among athletes can be explained by the theory of learned helplessness; however, some characteristics of athletes may be better described by attributional style in positive events.
Immigrant Asians and the Economic Impact of European Imperialism: The Role of the South Indian Chettiars in British Burma

The early debate over the economic impact of European imperialism on the Afro-Asian world centered largely upon the roles played by the European rulers. Both pro- and anti-imperialist writers focused on the introduction and effects of European economic policies and institutions, on the alleged benefits or exploitation that resulted from official and private European economic enterprise, and on the implications of European colonial control for the future economic development of subject areas. In recent years historians and other social scientists, drawing on hitherto neglected sources and applying new techniques of analysis, have undertaken a thoroughgoing reappraisal of the economic effects of European imperialism. One product of this effort has been the increased attention given by scholars to the important roles played by non-Europeans in the economic transformation of colonized areas.
Ct'* coordination in chlorites: a stmctural studv of ten chromian chlorites

In an effort to provide additional information on the coordination of Cr3* in chlorites, complete structural refinements were undertaken of two chromian chlorites from Day Book Body, North Carolina, and Siskiyou Co., California, both of which have been reported to contain predominantly tetrahedral Cf*. In addition, eight one-dimensional electron density projections were constructed from X-ray intensity data taken from eight different chromian chlorites, three of which were reported to have tetrahedral Cf*. The one-dimensional projections indicate the Ct'* and other heavy atoms to be concentrated in the interlayer octahedral sites. There is good agreement between the number of electrons per formula unit derived from integration of cation electron density peaks and the number calculated from the microprobe analyses under the assumption that all heavy atoms are concentrated in the interlayer. Both three-dimensional studies were done on IID-4 polytypes in triclinic space group Cl. In both structures the Cf* was preferentially concentrated in the M(4) octahedron on the inversion center within the interlayer. Si and Al were found to be disordered over the two independent tetrahedra. Sy'e propose that a combination ofcation repulsion and crystal field effects concentrates the Cf* in the M(4) octahedron, and that a disordered Si,Al distribution in tetrahedral sites provides the most favorable balance of charge around M(4). The cell angle c was found to be triclinic, and it is postulated that repulsion between the tetrahedral and M(4) cations causes this slewing of the structure. As no evidence of Cf* in tetrahedral coordination was found, we propose that the nemes kotschubeite and kiimmererite be discarded.
CT findings and progression of small peripheral lung neoplasms having a replacement growth pattern.

OBJECTIVE We investigated the imaging findings and progression of replacement lung neoplasms that were revealed on thin-section CT and serial CT. MATERIALS AND METHODS We evaluated the age of patients and thin-section CT findings (lesion size; percentage of ground-glass opacity areas; and presence or absence of solid portions, lobulation, coarse spiculation, air bronchogram, cavity, multiplicity, and pleural tags) in 73 lesions (11 atypical adenomatous hyperplasias, 17 type A [Noguchi's classification], 18 type B, and 27 type C small peripheral adenocarcinomas). We compared the serial findings of 48 of 73 lesions on low-dose screening CT (n = 21) or thin-section CT (n = 27) obtained at a mean interval of 450 days (range, 85-951 days). Progression from atypical adenomatous hyperplasia through type A to type B and then to type C tumor was studied using trend tests. RESULTS A significant linear trend was seen for lesion size (r = 0.55; p < 0.001), percentages of ground-glass opacity areas (r = 0.75; p < 0.001), and the prevalence of lobulation (p < 0.001), spiculation (p = 0.001), air bronchogram (p = 0.023), cavity (p = 0.046), pleural tag (p < 0.001), and solid portions (p < 0.001). In general from serial CT assessment, lesions were recognized first as a ground-glass opacity nodule (56% of 48 lesions) with subsequent increase in size (75%), then solid portions appeared in the nodule (17%), and finally solid portions increased (23%) with occasional augmentation of tissue contraction (6%). CONCLUSIONS CT analysis revealed stepwise progression of replacement-type lung neoplasms.
Evaluation of segmentation approaches and constriction degree correlates for spirant approximant consonants

(2.5%) ratio (97.5%) (SE) (2.5%) ratio (97.5%) Intercept -2.24(0.33)*** 0.06 0.11 0.20 -2.22(0.33)*** 1.00 1.00 1.00 Intensity 0.03(0.01)*** 0.06 0.11 0.21 0.01(0.01) 1.00 1.00 1.00 F1 0.00(0.00)*** 1.02 1.03 1.04 0.00(0.00)*** 1.00 1.00 1.00 F2 0.00(0.00)* 1.00 1.01 1.02 0.00(0.00)*** 1.00 1.00 1.00 Table 1: MLR results for the manual segmentation approach. Significance codes: ***, p < 0.001; **, p < 0.01; *, p < 0.05. Log-Likelihood (unexplained variability): -5334.9; McFadden R 2 (effect size): 0.017299; Likelihood ratio test (significant variability explained by model): 187.83, p < 0.001. (SE) (2.5%) ratio (97.5%) (SE) (2.5%) ratio (97.5%) Intercept -2.09(0.29)*** 0.07 0.12 0.22 -1.93(0.29)*** 0.08 0.15 0.26 Intensity 0.03(0.01)*** 1.02 1.03 1.04 0.02(0.01)** 1.00 1.02 1.03 F1 0.00(0.00)*** 1.00 1.00 1.00 0.00(0.00)*** 1.00 1.00 1.00 F2 0.00(0.00)* 1.00 1.00 1.00 0.00(0.00)*** 1.00 1.00 1.00 Table 2: MLR results for the automated data extraction approach. Significance codes: ***, p < 0.001; **, p < 0.01; *, p < 0.05. Log-Likelihood: -5348.2; McFadden R 2 : 0.014856; Likelihood ratio test: 161.3, p < 0.001. 4.24(0.79)*** 14.89 69.57 325.06 SpecTilt -0.01(0.00)*** 0.98 0.99 0.99 -0.01(0.00)*** 0.99 0.99 1.00 Table 3: MLR results for constriction degree intensity correlates. Significance codes: ***, p < 0.001; **, p < 0.01; *, p < 0.05. Log-Likelihood: -5268; McFadden R 2 : 0.029626; Likelihood ratio test: 321.67, p < 0.001.
Recruitment Policies in the Nigerian Federal Civil Service and Their Implications on Employees' Performance

Every organization regardless of its size, product or service must recruit applicants to fill vacant positions. The efficiency and effectiveness of any work place whether the private or public sector largely depend on the calibre of the work force. Within the framework of bureaucratic theory, the paper examined recruitment policies in Nigerian federal civil service and its implication on employee performance with a view of determining the challenges facing poor employees performance and recruitment of competent and qualified candidates into the service. The primary question that was explored is whether there is a relationship between recruitment policies in the federal civil service and employees’ performance. It established that, there is a significant relationship between recruitment policies and practices and employees performance in Nigerian federal civil service. The paper concludes that federal civil service is faced with poor recruitment policies and practices which have affected service delivery in service. Given the identified constraints, it recommends among others, that the current recruitment policy in the civil service that calls for uniform qualifications do not specify classification of degrees, diplomas and certificates should be modified to make provision on preference for candidates with outstanding results at all levels of education.
Cancer screening rate in people with diabetes in the Korean population: results from the Korea National Health and Nutrition Examination Survey 2007-2009

OBJECTIVES To investigate the screening rates for gastric, breast, and cervical cancer in people with diabetes compared with people without diabetes. METHODS Data from the Korea National Health and Nutrition Examination Survey (2007-2009) were used. Cancer-free men who were 40 years old and over and cancer-free women who were 30 years old and over were included. The lifetime screening rate and regular screening rate were compared in people with and without diabetes. RESULTS Fewer people with diabetes than people without diabetes had ever received cancer screening (53.5 vs. 59.5%, p<0.001 for gastric cancer; 60.5 vs. 71.5%, p<0.001 for breast cancer; and 49.1 vs. 59.6%, p<0.001 for cervical cancer). Fewer people with diabetes than people without diabetes received the recommended screenings for gastric cancer (38.9 vs. 42.9%, p<0.001), breast cancer (38.8 vs. 44.6%, p<0.001), and cervical cancer (35.1 vs. 51.2%, p<0.001). In subgroup analyses according to socioeconomic factors, the lifetime and recommended screening rates were lower in the diabetic population in most socioeconomic subgroups. In the multivariate analysis adjusted for socioeconomic factors, people with diabetes showed lower lifetime screening rates for gastric and cervical cancer (odds ratio [OR], 0.8; 95% confidence interval [CI], 0.7 to 0.9 and OR, 0.7; 95% CI, 0.6 to 0.9), and lower regular screening rates for breast and cervical cancer (OR, 0.7; 95% CI, 0.6 to 0.9 and OR, 0.7; 95% CI, 0.5 to 0.9). CONCLUSIONS The cancer screening rate in people with diabetes was lower than in people without diabetes. Considering the higher cancer risk in people with diabetes, efforts to increase the screening rate in this high-risk population should be implemented.
Risk Factors for Dementia Associated With Multiple Cerebral Infarcts: A Case-Control Analysis in Predominantly African-American Hospital-Based Patients

• Objective. —To clarify risk factors for dementia associated with cerebral infarction. Design. —Case-control study. Setting. —The study was conducted in a hospital setting. Patients. —The subjects were consecutive patients with acute stroke with multiple cerebral infarctions who were admitted to the hospital between November 1, 1987, and December 1, 1990. They were predominantly elderly African Americans. Index cases met criteria of the Diagnostic and Statistical Manual of Mental Disorders, Third Edition , for multi-infarct dementia, whereas control subjects were patients with multiple infarcts who did not have dementia. There were 61 multi-infarct disease index cases and 86 controls without cognitive impairment. Main Outcome Measures. —Demographic and cardiovascular disease risk factor variables. Results. —Index cases were older (mean [±SD] age, 75.5±9.7 vs 69.6±9.1 years), were less well educated (odds ratio, 4.37; confidence interval, 2.12 to 9.04), had lower annual incomes (odds ratio, 8.82; confidence interval, 2.38 to 32.70), more frequently had a family history of dementia (odds ratio, 3.61; confidence interval, 1.09 to 11.96) and laboratory evidence of proteinuria (odds ratio, 3.66; confidence interval, 1.54 to 8.71), had lower scores on neuropsychological tests, had more neurologic signs and symptoms, and were more functionally impaired in activities of daily living. Multiple logistic regression analysis showed that advanced age, lower educational attainment, history of myocardial infarction, and recent cigarette smoking were positively associated with case status and systolic blood pressure level was negatively associated with case status. Conclusions. —Cardiovascular disease risk factors may be modifiable predictors of dementia associated with cerebral infarction. Additional well-designed epidemiologic studies are needed to clarify these associations.
Deprenyl's effect at slowing progression of parkinsonian disability: the DATATOP study

Studying a cohort of 800 mildly‐affected parkinsonians, the North American DATATOP* project has concluded that progression in disability can be attenuated by the use of deprenyl, 10 mg/day. Interim results of this controlled clinical trial were reported after participants received treatment for an average of 12 months. The study found that deprenyl treatment almost halved the risk of reaching a stage of Parkinsonism at which the start of levodopa treatment becomes imperative for lessening disability. In addition to this study end‐point, other ratings supported an improved clinical outcome from the chronic deprenyl (DP) regimen. The 34 investigators conducted clinical evaluations both while subjects received medication and after a 4‐week wash‐out. Though some subjects experienced mild symptomatic improvements of Parkinsonism from DP, these effects were insufficient to account for the DP‐treated group's delay at reaching the study end‐point. In addition to DP, this placebo‐controlled double‐blind study also assessed the possibility of protective effects from another antioxidative strategy, a 2,000 I. U. /day regimen of alpha‐tocopherol. To date, results of the latter trial have not been reported.
Validation and further characterization of a major quantitative trait locus associated with host response to experimental infection with porcine reproductive and respiratory syndrome virus.

Infectious diseases are costly to the swine industry; porcine reproductive and respiratory syndrome (PRRS) is the most devastating. In earlier work, a quantitative trait locus associated with resistance/susceptibility to PRRS virus was identified on Sus scrofa chromosome 4 using approximately 560 experimentally infected animals from a commercial cross. The favorable genotype was associated with decreased virus load and increased weight gain (WG). The objective here was to validate and further characterize the association of the chromosome 4 region with PRRS resistance using data from two unrelated commercial crossbred populations. The validation populations consisted of two trials each of approximately 200 pigs sourced from different breeding companies that were infected with PRRS virus and followed for 42 days post-infection. Across all five trials, heritability estimates were 0.39 and 0.34 for viral load (VL; area under the curve of log-transformed viremia from 0 to 21 days post-infection) and WG to 42 days post-infection respectively. Effect estimates of SNP WUR10000125 in the chromosome 4 region were in the same directions and of similar magnitudes in the two new trials as had been observed in the first three trials. Across all five trials, the 1-Mb region on chromosome 4 explained 15 percent of genetic variance for VL and 11 percent for WG. The effect of the favorable minor allele at SNP WUR10000125 was dominant. Ordered genotypes for SNP WUR10000125 showed that the effect was present irrespective of whether the favorable allele was paternally or maternally inherited. These results demonstrate that selection for host response to PRRS virus infection could reduce the economic impact of PRRS.