Miracle-dz/UniFAR-FTUs huggingface dataset:
Effectiveness of Interactive Multimedia Based Learning Model in Engineering Mechanics.

Now the demand for skilled labor is urgent. Development of skilled labor has been done in various ways either through education and training. Indonesia, especially North Sumatra state nurture some vocational schools that produce graduates which are expected to be ready for working, but have not been able to meet these expectations. Therefore we face how to build a learning that is intended to establish effectively the competence of Vocational Middle School students. In this study, we propose an interactive multimedia-based learning model in teaching engineering mechanic competence. The results of empirical data showed significant evidence supports our proposition. It explores an important issue in developing the learning model of student competence in the field of engineering mechanic.
Age Is Not a Contraindication for Cartilage Surgery: A Critical Analysis of Standardized Outcomes at Long-term Follow-up

Background: Age is commonly accepted as a negative prognostic factor in cartilage surgery, and cutoff values of 30 to 40 years have been previously suggested as treatment indication. However, the lower outcome scores documented in older patients do not take in consideration the decreasing requirements of an aging joint. Purpose: To analyze the real effect of age in terms of recovery with respect to the functional level expected for different age categories of patients treated for cartilage lesions. Study Design: Cohort study; Level of evidence, 3. Methods: Patients with International Cartilage Repair Society (ICRS) grade 3-4 defects, involving femoral condyles or trochlea without osteoarthritis, were treated with arthroscopic matrix-assisted autologous chondrocyte transplantation; 157 patients were evaluated with IKDC subjective and Tegner scores before surgery and then after 2 and 10 years. Results were first evaluated by dividing patients into 2 age groups according to the generally approved cutoff value of 40 years. The analysis was then repeated after the scores of each patient were standardized according to the score achievable per the normative data in healthy patients for the corresponding sex and age category. Results: A significant improvement in all scores was observed. IKDC subjective score improved from 38.9 ± 14.5 to 74.7 ± 21.8 at 10 years. When a cutoff value of 40 years was used, older patients reached a significantly worse IKDC subjective value at 10 years (65.8 ± 24.3 vs 77.2 ± 20.4, P = .007). However, different findings were obtained after the scores were standardized. Although optimal results were still found in younger patients (<30 years), patients older than 40 years also appeared to benefit from the treatment, and no significant differences were noted compared with the younger population. Conclusion: The benefit of cartilage treatments in patients with increasing age but without any sign of osteoarthritis was higher than previously reported in literature. In fact, when the decreasing functional level expected by an aging population was considered, standardized results showed an overall benefit after cartilage treatment in patients older than 40 years that was not significantly different from the outcome achieved in younger patients. Thus, age is not a strict contraindication as previously suggested, and future studies should consider standardization of data to prove the real age limit of cartilage treatments.
Manual thrombectomy efficiency in relationship to the area at risk in patients with myocardial infarction with TIMI 0‐1 coronary flow: Insights from an all comers registry

To review the effectiveness of manual thrombectomy (MT) in a series of patients with ST‐elevation myocardial infarction (STEMI) exclusively presenting with TIMI 0‐1 flow undergoing percutaneous coronary intervention (PCI), in accordance to the angiographically estimated area at risk (AAR). Second, to assess major in‐hospital clinical events, emphasizing neurological outcomes.
Treadmill Injuries to the Upper Extremity in Pediatric Patients

Injury is the leading cause of preventable death and disability in childhood and early adulthood. Approximately 25,000 children are injured on exercise equipment each year. Although hand injuries sustained on stationary bicycles in the home have been well documented, little has been reported on home treadmill injuries. Between September 1996 and March 2000, the authors treated 12 children at The Children’s Hospital of Philadelphia for injuries to the upper extremity sustained on a treadmill. The age at the time of injury ranged from 14 months to 7 years, with a median age of 2.4 years. Average length of follow-up was 11.4 months. Ten of the 12 children sustained partial- or full-thickness burns to the volar aspect of the hand and digits. Overall, 6 patients required surgical repair. A total of 25% of the volar flexion creases involved required surgery. All patients had good functional results. The authors discuss the mechanism of injury, management, and measures to prevent treadmill injuries to children. To their knowledge, this is the first report of such injuries resulting from the use of a treadmill.
Developmental Regulation of Human Embryonic Stem Cell‐Derived Neurons by Calcium Entry via Transient Receptor Potential Channels

Spontaneous calcium (Ca2+) transients in the developing nervous system can affect proliferation, migration, neuronal subtype specification, and neurite outgrowth. Here, we show that telencephalic human neuroepithelia (hNE) and postmitotic neurons (PMNs) generated from embryonic stem cells display robust Ca2+ transients. Unlike previous reports in animal models, transients occurred by a Gd3+/La3+‐sensitive, but thapsigargin‐ and Cd2+‐insensitive, mechanism, strongly suggestive of a role for transient receptor potential (Trp) channels. Furthermore, Ca2+ transients in PMNs exhibited an additional sensitivity to the canonical Trp (TrpC) antagonist SKF96365 and shRNA‐mediated knockdown of the TrpC1 subunit. Functionally, inhibition of Ca2+ transients in dividing hNE cells led to a significant reduction in proliferation, whereas either pharmacological inhibition or shRNA‐mediated knockdown of the TrpC1 and TrpC4 subunits significantly reduced neurite extension in PMNs. Primary neurons cultured from fetal human cortex displayed nearly identical Ca2+ transients and pharmacological sensitivities to Trp channel antagonists. Together these data suggest that Trp channels present a novel mechanism for controlling Ca2+ transients in human neurons and may offer a target for regulating proliferation and neurite outgrowth when engineering cells for therapeutic transplantation. STEM CELLS 2009;27:2906–2916
Toward the Development of Radar Scene Analyzer for Cognitive Radar

In this paper, we propose a target signature search algorithm to address the radar scene analyzer in explicit terms for cognitive radar reception. A cognitive radar receiver encompasses two main blocks: the radar scene analyzer (RSA) and the Bayesian target tracker (BTT). The BTT needs to have prior knowledge of what it is looking for, such as terrain conditions, and the potential targets in that terrain. This information is provided by the RSA with the aid of other external resources. More formally, the statistical information about the environment and the target are central to the realization of the BTT. However, modeling the statistics of unknown target returns is a particularly challenging task. The objective of the proposed RSA structure is to tackle this challenge by extracting useful information about the target from the environment based on the texture modeling of sea clutter. Specifically, we formulate a weak target as an unknown input embedded in the sea surface, whose dynamics are closely coupled by those of the clutter. The mapping that governs the unknown system's dynamics is assumed to be smooth. The observables from the environment are then predicted one-step ahead with a bank of echo state networks (ESNs). The unknown target's signature is extracted from the ESN prediction error and then refined in two adaptive filtering stages. Performance of the resulting method is evaluated using the posterior Cramer-Rao lower bound (PCRB) on some controlled simulations. Finally, the intended application is presented on live recorded sea returns collected by the McMaster Intelligent PIXel Processing (IPIX) radar. Experiments show that the algorithm can accurately extract the target template from the environment.
Heightened Immune Activation in Fetuses with Gastroschisis May Be Blocked by Targeting IL-5

The development of the fetal immune system during pregnancy is a well-orchestrated process with important consequences for fetal and neonatal health, but prenatal factors that affect immune activation are poorly understood. We hypothesized that chronic fetal inflammation may lead to alterations in development of the fetal immune system. To test this hypothesis, we examined neonates with gastroschisis, a congenital abdominal wall defect that leads to exposure of the fetal intestines to amniotic fluid, with resultant intestinal inflammation. We determined that patients with gastroschisis show high systemic levels of inflammatory cytokines and chemokines such as eotaxin, as well as earlier activation of CD4+ and CD8+ effector and memory T cells in the cord blood compared with controls. Additionally, increased numbers of T cells and eosinophils infiltrate the serosa and mucosa of the inflamed intestines. Using a mouse model of gastroschisis, we observed higher numbers of eosinophils and both type 2 and type 3 innate lymphoid cells (ILC2 and ILC3), specifically in the portion of organs exposed to the amniotic fluid. Given the role of IL-5 produced by ILC2 in regulating eosinophil development and survival, we determined that maternal or fetal administration of the anti–IL-5 neutralizing Ab, or a depleting Ab against ILCs, can both effectively reduce intestinal eosinophilia. Thus, a congenital anomaly causing chronic inflammation can alter the composition of circulating and tissue-resident fetal immune cells. Given the high rate of prenatal and neonatal complications in these patients, such changes have clinical significance and might become targets for fetal therapy.
SISQL: schema-independent database querying (on and off the Web)

Finding information in diverse sources, in particular on the World-Wide Web is highly relevant these days. As more and more Web sites are administered by database systems, and as information on and off the Web increasingly comes out of a database, it is crucial to be able to search databases when working with the Web. This paper introduces a novel query language which renders it possible to formulate queries to databases in the absence of schema-knowledge. The proposed language Schema-Independent SQL (SISQL) takes parameterized SQL queries as input and dynamically generates correct SQL statements for collections of underlying schemata. SISQL is based on the Reflective Relational Algebra as a "processing engine,", which has been proposed in recent years for overcoming the limitations of classical algebra w.r. t. the treatment of procedural data.
Cabin1 expression suggests roles in neuronal development

Nervous system assembly and function depends on precise regulation of developmental gene expression. Cabin1, an essential gene in developing mice, is enriched in regions of the developing zebrafish central nervous system (CNS). Cabin1 is a repressor of MEF2‐ (myocyte enhancer factor 2) and calcineurin‐mediated transcription in the immune system, but its function in the CNS during development is unknown. We identified Cabin1 from a library of genes enriched in developing neurons and determined the temporal and spatial expression of Cabin1 mRNA during CNS development. We found Cabin1 mRNA expression in the developing brain at times correlated with later aspects of neuronal differentiation. In some regions of the CNS Cabin1 expression overlaps with regions that also express proteins known to interact with Cabin1: MEF2 and/or calcineurin. We suggest that Cabin1 could act as a regulator of MEF2 and calcineurin activity in the developing nervous system, given their roles in neuronal differentiation and synaptic refinement. Developmental Dynamics 239:2443–2451, 2010. © 2010 Wiley‐Liss, Inc.
Simulation of Oblique Evaporating Diesel Sprays, and Comparison with Empirical Correlations and Simulated Straight Sprays

The innovation in software analysis and various available programming facilities have urged the designers at various levels to do indispensable calculations for engine flows. Presently, the 3-D analysis approach is under practice to do simulations for various parameters involving engine operations using various softwares, “Fluent” being the trendiest at the moment for CFD modeling. The present work involves CFD modeling of diesel fuel sprays at a specified angle with cylinder axis. Fuel spray modeling includes sub-models for aerodynamic drag, droplet oscillation and distortion, turbulence effects, droplet breakup, evaporation, and droplet collision and coalescence. The data available from existing published work is used to model the fuel spray and the subsequent simulation results are compared to experimental results to test validity of the proposed models.
Resonant Tunneling in the Quantum Hall Regime: Measurement of Fractional Charge

In experiments on resonant tunneling through a "quantum antidot" (a potential hill) in the quantum Hall (QH) regime, periodic conductance peaks were observed as a function of both magnetic field and back gate voltage. A combination of the two periods constitutes a measurement of the charge of the tunneling particles and implies that charge deficiency on the antidot is quantized in units of the charge of quasi-particles of the surrounding QH condensate. The experimentally determined value of the electron charge e is 1.57 x 10–19 coulomb = (0.98 � 0.03) e for the states v = 1 and v = 2 of the integer QH effect, and the quasi-particle charge is 5.20 x 10–20 coulomb = (0.325 � 0.01)e for the state v = ⅓ of the fractional QH effect.
Scrub typhus in Punjab: an acute febrile illness with multisystem involvement

Scrub typhus is an important cause of acute febrile illness. This observational study describes the clinical features and complications of the patients diagnosed to have scrub typhus in Christian Medical College & Hospital, Ludhiana, Punjab, India. The diagnosis of scrub typhus was made by using Bioline SD Tsutsugamushi test kit which detects IgM, IgG or IgA antibodies to Orientia tsutsugamushi. Sixty-two patients of scrub typhus were seen during the study period of 1 year. The mean age of the study group was 39.9 years. All the patients presented with fever, and of these 31 (50%) had non-specific symptoms. All others had some complication, namely ARDS/ALI in 18 (29%), neurological involvement in 12 (19.4%), acute kidney injury (AKI) in 16 (25.8%), hypotension in eight (12.9%), thrombocytopenia in 23 (37.1%), hepatitis in 34 (54.8%) and MODS in 19 (30.7%). Eschar was present only in nine patients. Three patients expired due to multi-organ failure, hypotension and metabolic acidosis.
Evaluating the Impact of AAC Interventions in Reducing Hospitalization-related Stress: Challenges and Possibilities

Abstract Hospitalization is a stressful context for all children and their families, but especially for children with communication difficulties. Effective communication using augmentative and alternative communication (AAC) strategies can play a critical role in preparing and supporting everyone involved in such situations to have discussions that minimize insecurity, allow children to express their concerns, and so decrease negative stress and anxiety. However, there is a critical need to identify robust and reliable ways of evaluating the effectiveness of interventions that seek to achieve this aim. This research note illustrates some of the challenges and problems that require attention and suggests possible new research tools, for example, the use of physiological measures. The evaluation of an AAC intervention on a day surgery ward is described and used to illustrate one potential physiological measure for evaluating the impact of an intervention.
Cestodes (Caryophyllidea) of the Stinging Catfish Heteropneustes fossilis (Siluriformes: Heteropneustidae) from Asia

abstract: The stinging catfish Heteropneustes fossilis (Bloch) (Siluriformes: Heteropneustidae) has been reported to harbor as many as 19 species of caryophyllidean tapeworms (Cestoda) of 11 genera in tropical Asia (Indomalayan zoogeographical region). However, a critical review of the species composition has shown that only 1 species, Lucknowia fossilisi Gupta, 1961 (Lytocestidae), is a specific parasite of H. fossilis. Three other species, Djombangia penetrans Bovien, 1926 (syn., Djombangia caballeroi Sahay and Sahay, 1977), Pseudocaryophyllaeus ritai Gupta and Singh, 1983 (syn. Pseudocaryophyllaeus lucknowensis Gupta and Sinha, 1984), and Pseudocaryophyllaeus tenuicollis (Bovien, 1926) Ash, Scholz, Oros and Kar, 2011 (syn. P. mackiewiczi Gupta and Parmar, 1982), were found only once. Lucknowia fossilisi is redescribed on the basis of new material collected in West Bengal and voucher specimens from Maharashtra, India. A total of 9 species of Capingentoides, Lucknowia, Lytocestus, Pseudoadenoscolex, Pseudocaryophyllaeus, Pseudoheteroinverta, and Sukhapatae are newly synonymized with L. fossilisi and previous synonymies of 9 other species, proposed by Hafeezulah (1993), are confirmed. Generic diagnosis of Lucknowia Gupta, 1961 is amended. In addition, 1 species of Pseudobatrachus and 2 species of the monotypic genera Pseudoneckinverta and Sudhaena are invalidated as nomina nuda.
Modulation of Apoptosis in HaCaT Keratinocytes via Differential Regulation of ERK Signaling Pathway by Flavonoids*

The exact molecular mechanisms underlying the cellular effects associated with various flavonoids have yet to be fully explained. In the present study, we have administered several flavonoids to human HaCaT keratinocytes and determined that 3,4′-dihydroxy flavone (3,4′-DHF) exerts a slight stimulatory effect on cell growth, although other flavonoids, including kaempferol, quercetin, and isorhamnetin, exhibited growth inhibitory properties. 3,4′-DHF was found to exert an anti-apoptotic effect on etoposide-induced cell death of HaCaT keratinocytes. We were also able to determine that sustained ERK activation was intimately associated with the etoposide-induced apoptosis of HaCaT cells, and treatment with 3,4′-DHF induced a significant suppression of etoposide-induced ERK activation, concomitant with the repression of poly(ADP-ribose) polymerase or the cleavage of pro-caspase 3. ERK overexpression significantly overrode the anti-apoptotic function of 3,4′-DHF, but this was not true of ERK-DN. Moreover, treatment with 3,4′-DHF resulted in the protection of cells from H2O2-induced cell death and exerted an apparent suppressive effect on the stress-induced generation of reactive oxygen species (ROS). Finally, we showed that 3,4′-DHF almost completely abolished kaempferol-induced apoptosis, coupled with a concomitant suppression of both intracellular ROS generation and the activation of ERK. Taken together, our data clearly indicate that a host of phytochemicals, including etoposide and a variety of flavonoids, differentially regulate the apoptosis of human HaCaT keratinocytes via the differential modulation of intracellular ROS production, coupled with the concomitant activation of the ERK signaling pathway. According to these results, we are able to conclude the distinct structure-activity relationship between several flavonoids.
Radiographic Findings Associated with Surfactant Treatment

Radiographs of the chest (CXR) were evaluated in 35 of 41 infants enrolled in a randomized controlled trial of modified bovine surfactant extract (Surfactant-TA Tokyo-Tanabe) treatment. Infants between birthweight 1000 and 1500 gm with respiratory distress syndrome requiring mechanical ventilation and an inspired oxygen concentration 0.4 or greater were randomly assigned to either a single intratracheal dose of saline or surfactant-TA prior to 8 hours of age. Radiographs obtained prior to treatment and 24 hours after treatment were reviewed by a radiologist (N.T.G.) without knowledge of treatment group. Evaluation consisted of a score including criteria for inflation of the lungs, density of the lungs, and extent of air bronchograms. Pneumothorax, pulmonary interstitial emphysema, and asymmetric parenchymal involvement were noted as well. No significant difference in CXR scores were noted in the two groups, before or after treatment. There was a greater incidence of pneumothorax and pulmonary interstitial emphysema in the control infants, which supports the role of surfactant in preventing barotrauma. Increased incidence of asymmetric parenchymal involvement was noted in the surfactant-treated infants. Further study of the possibility of drug maldistribution is warranted.
Comments on "reaction time and attention in schizophrenia".

Nuechterlein's (1977) comprehensive and insightful review of the large literature on reaction time (RT) in schizophrenia should play a valuable role in stimulating thinking and further research in this field. Even to those who have kept up with the literature there is great value in having the basic findings all down in one place and conveniently organized so that they can be seen more easily as a whole and, not incidentally, can serve as an obstacle to selective perception (or selective forgetting) in favor of those results that support the reader's own theoretical persuasions. In the comments to follow, certain points raised in the review will be underlined, certain specific and general theoretical issues will be discussed, and forecasts will be made about the future course of research in this area, all in a highly selective fashion without an attempt to be comprehensive.
Development and Application of an Arabinose-Inducible Expression System by Facilitating Inducer Uptake in Corynebacterium glutamicum

ABSTRACT Corynebacterium glutamicum is currently used for the industrial production of a variety of biological materials. Many available inducible expression systems in this species use lac-derived promoters from Escherichia coli that exhibit much lower levels of inducible expression and leaky basal expression. We developed an arabinose-inducible expression system that contains the l-arabinose regulator AraC, the PBAD promoter from the araBAD operon, and the l-arabinose transporter AraE, all of which are derived from E. coli. The level of inducible PBAD -based expression could be modulated over a wide concentration range from 0.001 to 0.4% l-arabinose. This system tightly controlled the expression of the uracil phosphoribosyltransferase without leaky expression. When the gene encoding green fluorescent protein (GFP) was under the control of PBAD promoter, flow cytometry analysis showed that GFP was expressed in a highly homogeneous profile throughout the cell population. In contrast to the case in E. coli, PBAD induction was not significantly affected in the presence of different carbon sources in C. glutamicum, which makes it useful in fermentation applications. We used this system to regulate the expression of the odhI gene from C. glutamicum, which encodes an inhibitor of α-oxoglutarate dehydrogenase, resulting in high levels of glutamate production (up to 13.7 mM) under biotin nonlimiting conditions. This system provides an efficient tool available for molecular biology and metabolic engineering of C. glutamicum.