Miracle-dz/UniFAR-FTUs huggingface dataset:
Replication intermediate analysis confirms that chromosomal replication origin initiates from an unusual intergenic region in Caulobacter crescentus.

The alpha-proteobacterium Caulobacter crescentus possesses a developmental cell cycle that restricts chromosome replication to a stalked cell type. The proposed C.crescentus chromosome replication origin (Cori) lies between hemE and RP001, an unusual intergenic region not previously associated with bacterial replication origins, although a similar genomic arrangement is also present at the putative replication origin in the related bacterium Rickettsia prowazekii. The cloned Cori supports autonomous plasmid replication selectively in the stalked cell type implying that replication of the entire chromosome also initiates between hemE and RP001. To confirm this location, we applied the 2-D (N/N) agarose gel electrophoresis technique to resolve and identify chromosome replication intermediates throughout a 30 kb region spanning Cori. Replication initiation in Cori was uniquely characterized by an 'origin bubble and Y-arc' pattern and this observation was supported by simple replication fork 'Y-arc' patterns that characterized the regions flanking Cori. These replication forks originated bi-directionally from within Cori as determined by the fork direction assay. Therefore, chromosomal replication initiates from the unusual hemE/RP001 intergenic region that we propose represents a new class of replication origins.
Valuing leasing risks in commercial property with a discrete‐time binomialtree option model

This paper models the lessee's default options and estimates the economic value of the options for a lessee using a discrete time binomial American option pricing model. Results show a positive relationship of the option premium with the original rent and a negative relationship with the relocation costs. Finds that the default probability is higher for lessees who are more sensitive to rental changes and place less emphasis on the fitting‐out quality. Suggests that rental volatility and rental growth rate are two significant factors that have positive relationships with the default option values. The risk‐free rate, on the other hand, has an inverse relationship with the default option values because a higher risk‐free interest rate reduces the present value of rental savings. Lease term length to expiration has a positive effect on the default option value, implying that the default option premium will decay as the term to expiry is shortened.
Research to Estimate and Manage Carrying Capacity of a Tourist Attraction: A Study of Alcatraz Island

Carrying capacity has been a long-standing issue in management of parks, outdoor recreation and tourism. Contemporary carrying capacity frameworks rely on formulation of indicators and standards of quality to define and manage carrying capacity. This paper describes a programme of research to support estimation and management of carrying capacity of Alcatraz Island, an historic site within Golden Gate National Recreation Area, California, USA, and a heavily visited tourist attraction. Research included: (1) a survey of visitors to Alcatraz Island to identify indicators and standards of quality for the visitor experience; and (2) development of a computer simulation model of visitor use to estimate maximum daily use levels without violating standards of quality. Study findings are used to estimate a range of carrying capacities for the prison cellhouse and for the island as a whole.
Forced Labour in Franco's Spain: Workforce Supply, Profits and Productivity

This article analyses the forced labour system created in Spain during the Civil War and maintained during the Francoist dictatorship, paying special attention to the economic logic that led the state and private enterprises to draw a profit from this kind of punishment. In order to deal with this question in depth my research has been focused on three main aspects: the workforce supply in a war economy and in a context of reconstruction, the margins of profit produced by this kind of labour in comparison with free labour, and the problems related to productivity levels. Through consideration of these questions I present an overview of the main research in the subject and make suggestions for new goals in Spanish economic history concerned with this kind of repressive practice, bringing it into line with international historiography on the forced labour economy.
Variable structure flow controller for connection-oriented communication networks

In this paper we propose a new variable structure, flow controller for multi-source connection-oriented data transmission networks. Each connection in the considered networks is characterized by a time delay and a packet loss ratio. The proposed controller takes advantage of an appropriately designed sliding hyperplane, which ensures the closed-loop system stability and finite-time error convergence to zero. Moreover, the proposed controller ensures full utilization of the bottleneck link available bandwidth, guarantees bounded transmission rates, and eliminates the risk of buffer overflow in the bottleneck node. The proposed controller is designed using the concept of the reaching law, which helps to limit data transmission rates in the network.
Fighting Arbovirus Transmission: Natural and Engineered Control of Vector Competence in Aedes Mosquitoes

Control of aedine mosquito vectors, either by mosquito population reduction or replacement with refractory mosquitoes, may play an essential role in the fight against arboviral diseases. In this review, we will focus on the development and application of biological approaches, both natural or engineered, to limit mosquito vector competence for arboviruses. The study of mosquito antiviral immunity has led to the identification of a number of host response mechanisms and proteins that are required to control arbovirus replication in mosquitoes, though more factors influencing vector competence are likely to be discovered. We will discuss key aspects of these pathways as targets either for selection of naturally resistant mosquito populations or for mosquito genetic manipulation. Moreover, we will consider the use of endosymbiotic bacteria such as Wolbachia, which in some cases have proven to be remarkably efficient in disrupting arbovirus transmission by mosquitoes, but also the use of naturally occurring insect-specific viruses that may interfere with arboviruses in mosquito vectors. Finally, we will discuss the use of paratransgenesis as well as entomopathogenic fungi, which are also proposed strategies to control vector competence.
ACCULTURATION OF ASIAN INDIAN WOMEN IN THE UNITED STATES

OF DISSERTATION ACCULTURATION OF ASIAN INDIAN WOMEN IN THE UNITED STATES The United States is home to nearly three million Asian Indians. The difference in Asian Indian and American cultures creates a need for Asian Indians to acculturate, upon migration to the U.S. It has been theorized that acculturation becomes harder when the two cultures of contact are dissimilar. Particularly, immigrant women and children have been found to be more vulnerable than men to acculturative stress, where acculturative stress is defined as the psychological impact of adaptation to a new culture. Hence, this study focuses on acculturation of Asian Indian women and specifically on factors influencing their acculturation. Research findings from this study on acculturation of Asian Indian women provide information, useful for public policy makers. They have been utilized to develop a program (used by settlement service providers) designed specifically to facilitate acculturation of Asian Indian women in the U.S. A two-dimensional model developed by J.W. Berry, a prominent researcher in the field of acculturation, is employed to classify the acculturation process of Asian Indian women who were part of this study. Based on Berry’s model, the acculturation process of an immigrant can be described by one of the following four strategies: 1) Assimilation, 2) Integration, 3) Separation, or 4) Marginalization. According to Berry, the Integration strategy is considered the most effective acculturation strategy in terms of long-term health and wellbeing of the individual. This study employed a cross-sectional design, using quantitative methods for data analysis. Data were collected by means of a web-based acculturation survey that was developed as part of the study. Data analysis indicated that a majority of the Asian Indian women adopted the Integration strategy. A conceptual model was developed and multivariate analyses were conducted to examine the key acculturation factors that influenced Asian Indian women using the Integration strategy. These identified key factors helped to understand the cultural adaptation of Asian Indian women.
CSR disclosures and its determinants: evidence from Malaysian government link companies

Purpose – The main aim of this study is to assess the level of corporate social responsibility (CSR) disclosure of 44 government-linked companies (GLCs) listed on Bursa Malaysia and to ascertain the relationship of certain company characteristics; namely size, age, profitability and leverage on the total CSR disclosure from the year 2005 to 2006. Design/methodology/approach – Content analysis is deployed to determine CSR disclosure. A disclosure index consisting of 16 items was developed based on four general themes: human resource, marketplace, community and environment to assess the disclosure level. The relationship between company characteristics and total disclosure was examined using multiple linear regression analysis. Findings – The major finding of this study is that the theme of disclosure has shifted from human resource to marketplace. This is followed by human resource, community and, finally, environment. Ironically, companies are not only disclosing good news, but also bad/negative news. This study provides further evidence that is, to a certain extent, some GLCs have influenced other companies' practices to disclose CSR information. Company size was found to be positively significant associated with the total disclosure. The remaining variables were found to be insignificant in explaining the total disclosure. Originality/value – This is the first paper that looks into CSR activities, extent, themes and the determinants of CSR disclosure in the annual reports of Malaysian GLCs. The Malaysian Government, Bursa Saham, Security Commission and other relevant parties could take heed of the findings to further improve CSR awareness, practices and disclosures and quality in GLC.
Overview of the Investigation and Management of Cystic Neoplasms of the Pancreas

Background: Cystic neoplasms of the pancreas contribute to 10–20% of pancreatic tumours. Malignant cystic tumours of the pancreas behave similar to adenocarcinomas and thus warrant aggressive management. However, certain benign cystic neoplasms do not require operative intervention. It is, therefore, important to differentiate benign lesions from malignant lesions and from those with malignant potential. Aims: To provide an overview of the role of radiological investigations in the management of cystic neoplasms of the pancreas, with emphasis on the characteristic features of aggressive tumours. The role of different imaging modalities is discussed, and an investigative algorithm suggested. Methods: A literature review was carried out on Medline, Cochrane library, and PubMed using the MeSH terms ‘pancreas’ and ‘cysts’ to source relevant papers. Search criteria were limited to English literature, meta-analyses, systematic reviews, prospective and retrospective case series, published during or after 1998. Discussion: Each pancreatic cystic lesion has characteristic radiological findings. However, the diagnostic accuracy of individual imaging techniques is still limited. A combination of imaging modalities is essential for preoperative diagnosis. CT complemented by endoscopic ultrasound and cyst fluid analysis appears to be the most promising investigation in diagnosing cystic neoplasms. Follow-up with serial imaging is useful for lesions of uncertain aetiology.
Moral Person and Moral Manager: How Executives Develop a Reputation for Ethical Leadership

Executives should not take a reputation for ethical leadership for granted. Based on interviews with senior executives and corporate ethics officers, this article reveals that a reputation for executive ethical leadership rests on two essential pillars: the executive's visibility as a moral person (based upon perceived traits, behaviors, and decision-making processes) and visibility as a moral manager (based upon role modeling, use of the reward system, and communication). Developing a reputation for ethical leadership pays dividends in reduced legal problems and increased employee commitment, satisfaction, and employee ethical conduct. The alternatives are the unethical leader, the hypocritical leader (who talks the talk, but doesn't walk the walk), and the ethically neutral leader (who may be an ethical person, but employees don't know it because the leader has not made ethics and values an explicit part of the leadership agenda). The article also offers guidelines for cultivating a reputation for ethical leadership.
Making Summer Matter: The Impact of Youth Employment on Academic Performance

This paper examines New York City's Summer Youth Employment Program (SYEP). SYEP provides jobs to youth ages 14–24, and due to high demand for summer jobs, allocates slots through a random lottery system. We match student‐level data from the SYEP program with educational records from the NYC Department of Education and use the random lottery to estimate the effects of SYEP participation on a number of academic outcomes, including test taking and performance. We find that SYEP participation has positive impacts on student academic outcomes, and these effects are particularly large for students who participate in SYEP multiple times.
CD40 Ligation Prevents Trypanosoma cruziInfection through Interleukin-12 Upregulation

ABSTRACT Because of the critical role of the CD40-CD40 ligand (CD40L) pathway in the induction and effector phases of immune responses, we investigated the effects of CD40 ligation on the control ofTrypanosoma cruzi infection. First, we observed that supernatants of murine spleen cells stimulated by CD40L-transfected 3T3 fibroblasts (3T3-CD40L transfectants) prevent the infection of mouse peritoneal macrophages (MPM) by T. cruzi. This phenomenon depends on de novo production of nitric oxide (NO) as it is prevented by the addition of N-nitro-l-arginine methyl ester, a NO synthase inhibitor. NO production requires interleukin (IL)-12-mediated gamma interferon (IFN-γ) and tumor necrosis factor alpha (TNF-α) synthesis as demonstrated by inhibition experiments using neutralizing anti-IL-12, anti-IFN-γ, and anti-TNF-α monoclonal antibodies (MAb). We found that an activating anti-CD40 MAb also directly stimulates IFN-γ-activated MPM to produce NO and thereby to control T. cruzi infection. To determine the in vivo relevance of these in vitro findings, mice were injected with 3T3-CD40L transfectants or 3T3 control fibroblasts at the time ofT. cruzi inoculation. We observed that in vivo CD40 ligation dramatically reduced both parasitemia and the mortality rate of T. cruzi-infected mice. A reduced parasitemia was still observed when the injection of 3T3-CD40L transfectants was delayed 8 days postinfection. It was abolished by injection of anti-IL-12 MAb. Taken together, these data establish that CD40 ligation facilitates the control of T. cruzi infection through a cascade involving IL-12, IFN-γ, and NO.
Using stretch goals to promote organizational effectiveness and personal growth: General Electric and Goldman Sachs

The article discusses the establishment of stretch-goal initiatives at General Electric (GE) and Goldman Sachs (GS) and presents a comparative study based on their differing goals and industries. The article first discusses GE's program to enhance organizational effectiveness. GE's focus on intraorganizational cooperation is highlighted, as well as how they established metrics and handled failure. At GS, the overall goal was different. GS was looking for improvement in professional development. Therefore, the goals were developed through personal action plans with stretch goals developed individually (vertically) and by department (horizontally). Further discussion of the nature of these initiatives and the support structure necessary for success are presented.
The impact of bureaucracy, corruption and tax compliance

Purpose – Tax compliance has been studied by analyzing the individual decision of a representative person between planning and evading taxes. A neglected aspect of tax compliance is the impact of bureaucracy and corruption. Both bureaucracy and corruption are hypothesized to have a negative impact on tax compliance. Aims to examine this issue. Design/methodology/approach – Based on empirical evidence from 30 developed and developing countries. Findings – Finds that tax compliance internationally is negatively related to the levels of bureaucracy and positively related to the successful control of corruption. The paper shows that a powerful deterrent is the creation of a tax morale or climate, where citizens are protected from corruption and bloated burequcracies. Originality/value – The findings are of great value to developing countries that need to reduce both the level of corruption and bureaucracy in order to create the type of tax morale conducive to both tax compliance and economic development.
The Fashion-Conscious Behaviours of Mature Female Consumers

Under-appreciation of mature consumers as a numerous and comparatively wealthy market segment has resulted in not only lost revenues for business, but also lost consumption and service opportunities for the elderly. In response to expressed needs for more research into actual and desired consumption by older consumers, this study examined the apparel and shopping preferences of mature women in America. Independent living residents were surveyed concerning fashion consciousness, fashion information sources and shopping behaviours. Young and mature consumers reactions to female apparel ensembles were compared. Mature subjects purchased apparel for pleasure or need, but less for conformity. Decisions were influenced more by fit and comfort than by fashion, despite suggestions that dressing stylishly was important. New fashions were encountered via catalogue illustrations, social gatherings and window displays. Subjects high in fashion consciousness had greater financial and social involvement with fashion, greater chronological-to-cognitive age differences and larger clothing budgets. Young and mature consumers responses to apparel illustrations differed significantly. As the mature market expands, attention to age-divergent definitions of fashion (such as those based upon admiration of comfort) will determine the success of apparel businesses. Assessment of cognitive age will facilitate identification of those mature consumers most predisposed toward fashion consumption.
Seasoned Equity Offerings, Corporate Governance, and Investments

We find weak governance is a primary reason investors react negatively to the announcement of seasoned equity offerings (SEOs). Using a difference-in-differences approach, we find investors worry about nonproductive use of SEO proceeds when external pressure for good governance lifts due to an external shock. Investors react negatively only when treated firms raise funds to increase capital investments. Market reaction is more negative when issuers have prior records of value-reducing acquisitions and weaker managerial wealth sensitivity to shareholder value. The magnitudes of these governance effects are surprisingly large, explaining most of the previously documented negative market reactions to primary SEOs.
Risk, Crop Choice, and Savings: Evidence from Tanzania

Rural households engaged in agricultural activities face considerable risks in their income process. These income risks are especially important if they result in consumption fluctuations. This is likely if insurance and credit markets are absent. One possible strategy for household is to take up low-risk activities, even if they imply lower returns. Such response cannot be viewed independently from the other options available to households to reduce consumption fluctuations. This paper focuses on the importance of liquid asset formation for risk-taking behaviour by households. An intertemporal model of consumption under liquidity constraints is developed in which households can choose between income activities with different returns and riskiness. It shows that if liquid asset holdings are large, providing a buffer for consumption shortfalls, then households will be more willing to take up high risk activities. Evidence based on survey data from Shinyanga District, Tanzania is presented, consistent with this prediction.
Over-the-Counter Agents for the Treatment of Occasional Disturbed Sleep or Transient Insomnia: A Systematic Review of Efficacy and Safety.

OBJECTIVE To investigate the level of evidence supporting the use of common over-the-counter (OTC) agents (diphenhydramine, doxylamine, melatonin, and valerian) for occasional disturbed sleep or insomnia. DATA SOURCES A systematic review of the literature was conducted on July 31, 2014, using MEDLINE (PubMed) and the search terms (insomnia OR sleep) AND (over*the*counter OR OTC OR non*prescription OR antihistamine OR doxylamine OR diphenhydramine OR melatonin OR valerian) with the filters English, human, and clinical trials. STUDY SELECTION Identified publications (from 2003 to July 31, 2014, following previous published literature reviews) that met the inclusion criteria were selected. The criteria included randomized placebo-controlled clinical studies that utilized overnight objective (polysomnography) or next-day participant-reported sleep-related endpoints and that were conducted in healthy participants with or without occasional disturbed sleep or diagnosed insomnia. RESULTS Measures of efficacy and tolerability were summarized for each study individually and grouped according to OTC agent: H1 antagonists or antihistamines (3 studies, diphenhydramine), melatonin (8), and valerian or valerian/hops (7). Of the 3 sleep agents, studies conducted with melatonin, especially prolonged-release formulations in older individuals with diagnosed insomnia, demonstrated the most consistent beneficial effects (vs placebo) on sleep measures, specifically sleep onset and sleep quality, with favorable tolerability. In contrast, the clinical trial data for diphenhydramine, immediate-release melatonin, and valerian suggested limited beneficial effects. CONCLUSIONS A review of randomized controlled studies over the past 12 years suggests commonly used OTC sleep-aid agents, especially diphenhydamine and valerian, lack robust clinical evidence supporting efficacy and safety.
Towards an understanding of older adult educational tourism through the development of a three-phase integrated framework

As a direct consequence of global ageing patterns, older travellers have become a significant proportion of annual total holiday spending. In addition, this has also brought with it a shift in the types of travel experiences that older travellers are now choosing. Educational and cultural touristic experiences are now becoming popular options for many older individuals, as they provide greater opportunities for meaningful engagement as well as tapping into their renewed interest for history and nostalgia. At the same time, older travellers are placing a greater value on lifelong learning that may help to enrich their life. This paper provides a comprehensive review of the educational travel experiences of older adults through the development of an integrated framework that links the three stages of educational travel: pre-travel, participation, and post-travel. It is envisaged that this framework will contribute to the development of a conceptual model for successful ageing that acknowledges the significant impact that educational travel experiences will have on the well-being of older tourists.