Miracle-dz/UniFAR-FTUs huggingface dataset:
Thalamocortical dysrhythmia: A neurological and neuropsychiatric syndrome characterized by magnetoencephalography.

Spontaneous magnetoencephalographic activity was recorded in awake, healthy human controls and in patients suffering from neurogenic pain, tinnitus, Parkinson's disease, or depression. Compared with controls, patients showed increased low-frequency theta rhythmicity, in conjunction with a widespread and marked increase of coherence among high- and low-frequency oscillations. These data indicate the presence of a thalamocortical dysrhythmia, which we propose is responsible for all the above mentioned conditions. This coherent theta activity, the result of a resonant interaction between thalamus and cortex, is due to the generation of low-threshold calcium spike bursts by thalamic cells. The presence of these bursts is directly related to thalamic cell hyperpolarization, brought about by either excess inhibition or disfacilitation. The emergence of positive clinical symptoms is viewed as resulting from ectopic gamma-band activation, which we refer to as the "edge effect. " This effect is observable as increased coherence between low- and high-frequency oscillations, probably resulting from inhibitory asymmetry between high- and low-frequency thalamocortical modules at the cortical level.
Recovery opportunities, work–home conflict, and emotional exhaustion among hematologists and oncologists in private practice

Abstract Hematologists and oncologists in private practice play a central role in the care provided for cancer patients. The present study analyzes stress and relaxation aspects in the work of hematologists and oncologists in private practice in Germany in relation to emotional exhaustion, as a core dimension of burnout syndrome. The study focuses on the opportunities for internal recovery using breaks and time out during the working day, the frequency of working on weekends and on vacation, and the physician’s work–home and home–work conflict. Postulated associations between the constructs were analyzed using a structural equation model. If work leads to conflicts in private life (work–home conflict), it is associated with greater emotional exhaustion. Working frequently at the weekend is associated with greater work–home conflict and indirectly with greater emotional exhaustion. By contrast, the availability of opportunities to relax and recover during the working day is associated with less work–home conflict and indirectly with less emotional exhaustion. These results underline the importance of internal recovery opportunities during the working day and a successful interplay between working and private life for the health of outpatient hematologists and oncologists.
KOF Working Papers

This study analyzes how competition affects price stickiness at the micro level. On the theoretical side, I develop what I call a micro Phillips curve, i.e. a productspecific relation between inflation and economic activity conditional on inflation expectations. I find two opposing effects of competition on the slope of the micro Phillips curve. On the one hand, stronger competition leads to a higher frequency of price revaluations, implying a steeper slope. On the other hand, the stronger competition is, the less firms can transmit changes in economic activity into price changes, implying a flatter slope. Using unique product-level manufacturing panel data, I find that the latter effect clearly dominates and plays an important role in explaining price stickiness. The effect of a marginal increase in economic activity on the likelihood of a price increase is between 63% and 85% lower for products, that face very strong competition, compared to products, that face very weak competition. In line with the theory, prices of products, that face very strong competition, are also less likely to decrease in response to marginal decreases in economic activity. Moreover, it heavily depends on the degree of competition that a product faces whether, and to what extent, the micro Phillips curve is non-linear. The stronger the competition the weaker will be the non-linearity of the micro Phillips curve. My findings imply that effective business cycle policy necessitates good competition policy. Reforms which strengthen the competition in an economy will make stimulus or stabilization policy more effective. Furthermore, the results imply that stimulus or stabilization measures, that target specifically high competition firms or sectors, may be more effective than programs, that follow an indiscriminate all-round principle. JEL codes: E31, E32
Influence of conventional cardiovascular risk factors and lifestyle characteristics on cardiovascular disease after hematopoietic cell transplantation.

PURPOSE To determine the influence of modifiable lifestyle factors on the risk of cardiovascular disease after hematopoietic cell transplantation (HCT). PATIENTS AND METHODS HCT survivors of ≥ 1 year treated from 1970 to 2010 (n = 3,833) were surveyed from 2010 to 2011 on current cardiovascular health and related lifestyle factors (smoking, diet, recreational physical activity). Responses (n = 2,362) were compared with those from a matched general population sample (National Health and Nutrition Examination Survey [NHANES]; n = 1,192). RESULTS Compared with NHANES participants, HCT survivors (median age, 55.9 years; median 10.8 years since HCT; 71.3% allogeneic) had higher rates of cardiomyopathy (4.0% v 2.6%), stroke (4.8% v 3.3%), dyslipidemia (33.9% v 22.3%), and diabetes (14.3% v 11.7%; P < .05 for all comparisons). Prevalence of hypertension was similar (27.9% v 30.0%), and survivors were less likely to have ischemic heart disease (6.1% v 8.9%; P < .01). Among HCT survivors, hypertension, dyslipidemia, and diabetes were independent risk factors for ischemic heart disease and cardiomyopathy, and smoking was associated with ischemic heart disease and diabetes (odds ratios [ORs], 1.8 to 2.1; P = .02). Obesity was a risk factor for post-transplantation hypertension, dyslipidemia, and diabetes (ORs ≥ 2.0; P < .001). In contrast, lower fruit/vegetable intake was associated with greater risk of dyslipidemia and diabetes (ORs, 1.4 to 1.8; P ≤ .01), and lower physical activity level was associated with greater risk of hypertension and diabetes (ORs, 1.4 to 1.5; P < .05). Healthier lifestyle characteristics among HCT survivors attenuated risk of all cardiovascular conditions assessed. CONCLUSION Attention of clinicians to conventional cardiovascular risk factors and modifiable lifestyle characteristics offers hope of reducing serious cardiovascular morbidity after HCT.
Diagnostic paradigm for evaluation of male patients with chronic granulomatous disease, based on the dihydrorhodamine 123 assay.

BACKGROUND Chronic granulomatous disease (CGD) is a phagocyte disorder caused by mutations in nicotinamide dinucleotide phosphate (NADPH) oxidase subunits. The dihydrorhodamine 123 (DHR) assay is an effective test for CGD that for most patients also might help to differentiate between the 2 most common forms, X-linked (X) gp91(phox) defect CGD and autosomal recessive (AR) p47(phox) defect CGD. However, some male patients with X-CGD have DHR patterns that overlap the AR-CGD pattern. OBJECTIVE The purpose of this investigation was to develop a diagnostic paradigm to delineate male patients with X-CGD expressing a DHR pattern suggestive of p47(phox) deficiency. METHODS The DHR assay measured change in fluorescence of DHR-loaded granulocytes after phorbol myristate acetate (PMA) stimulation. Western blot analysis measured the presence of NADPH oxidase subunits gp91(phox), p47(phox), p67(phox), and p22(phox). CYBB exonic sequencing was performed on PCR-amplified genomic DNA through use of intronic flanking primers. Ferricytochrome-c assay evaluated specific superoxide production by PMA-stimulated granulocytes. RESULTS Although 83% of patients with X-CGD have virtually no neutrophil DHR activity, we found that 17% of patients, proven to have X-CGD by other criteria, have modest DHR activity that is most consistent with p47(phox) deficiency. We describe a diagnostic paradigm to deal with such patients, and we present 2 cases, along with results of additional studies, including carrier evaluation, protein assessment, and mutation analysis, that are useful in establishing the genotype under these circumstances. DHR assays from the 2 patients described showed a fluorescence shift most characteristic of p47(phox)-AR-CGD; however, each of the patients' mothers showed mosaicism with a bimodal DHR pattern. Patient 1 had some gp91(phox) protein with a Y41D mutation and modest superoxide activity. Patient 2 had a normal level of gp91(phox) protein with a C537R mutation without detectable superoxide activity, as determined by ferricytochrome-c assay, despite the modest DHR activity. CONCLUSIONS Evaluation of male patients with CGD with modest DHR activity should initially include evaluation of potential female carriers for mosaicism with the use of the DHR assay. In circumstances in which this is uninformative, patients should be referred to centers capable of additional testing, including Western blot analysis and CYBB mutation analysis, to clarify the disease genotype.
Filling the Blanks (hint: plural noun) for Mad Libs Humor

Computerized generation of humor is a notoriously difficult AI problem. We develop an algorithm called Libitum that helps humans generate humor in a Mad Lib, which is a popular fill-in-the-blank game. The algorithm is based on a machine learned classifier that determines whether a potential fill-in word is funny in the context of the Mad Lib story. We use Amazon Mechanical Turk to create ground truth data and to judge humor for our classifier to mimic, and we make this data freely available. Our testing shows that Libitum successfully aids humans in filling in Mad Libs that are usually judged funnier than those filled in by humans with no computerized help. We go on to analyze why some words are better than others at making a Mad Lib funny.
In vitro studies on the generation of lymphocyte diversity.

The following topics are discussed: local and systemic factors regulating lymphocytes production; delineation of the diverse sites of lymphocyte maturation; experimental models for the study of local factors in lymphocyte differentiation; hormonal involvement in lymphocyte differentiation; and the functional status of differentiating lymphocytes in various organs. (HLW)
Computer Self-Efficacy among Senior High School Teachers in Ghana and the Functionality of Demographic Variables on Their Computer Self-Efficacy.

The study is aimed at investigating 1) the level of computer self-efficacy among public senior high school (SHS) teachers in Ghana and 2) the functionality of teachers’ age, gender, and computer experiences on their computer self-efficacy. Four hundred and Seven (407) SHS teachers were used for the study. The “Computer SelfEfficacy” (CSE) scale, developed by Teo and Koh (2010) was adapted and used for data collection. Descriptive statistics, t tests and univariate analyses were employed to analyse the data. The results showed that generally, SHS teachers neither disagree nor agree that they are computer self-efficacious; specifically they agree that they are self-efficacious in basic computer skills but not certain about their self-efficacy in web based skills and not self-efficacious in media related computer skills. Moreover, the results revealed that teachers’ age, gender, and computer experiences have similar and dissimilar influences on their computer self-efficacy related to different computer application software. Furthermore, according to the results, teachers’ gender and their computer experience have interaction effect on their computer self-efficacy whilst 1) teachers’ gender and age and 2) teachers’ age and computer experience have no statistically significant interaction effect on their computer selfefficacy. The study provides new and vital information for educational practitioners in Ghana. The findings suggest that xpecting teachers in developing country such as Ghana to teach with technology still remains as a very challenging issue which requires important attention. In addition, the study provides new insights into explanation for contradictory research findings of the effect of (SHS) teachers’ age, gender, and computer experience on their computer self-efficacy in the literature.
Changes in CSF hypocretin-1 (orexin A) levels in rats across 24 hours and in response to food deprivation

Hypocretin-1 is consistently detectable in the CSF of healthy human subjects, but is absent in narcoleptics. However, functional roles of CSF hypocretin are largely unknown. We examined fluctuation of CSF hypocretin-1 across 24 h and in response to food restriction in rats. Hypocretin-1 levels were high during the dark period when animals were active, but decreased by 40% toward the end of the light (rest) period. After 72 h food deprivation hypocretin-1 levels during the rest phase increased to concentrations similar to those seen during the baseline active phase; however, no increase in response to food deprivation was observed during the active phase. These results indicate an important link between circadian control of sleep and energy homeostasis via the hypocretin system.
Growing Older

This study explored experiences of eight rural, Anglo-Australian women aged between 65 and 75 using semi-structured interviews. Thematic analysis revealed three prominent themes: (a) the free and busy me highlights the increased freedom in later life enabling choices regarding activities the women would like to engage in; (b) the secret is being positive and pragmatic emphasizes the importance of adopting a pragmatic acceptance of growing older; and (c) narratives of growth and stagnation highlights the pursuit of growth among older women in order to enhance the current self. Findings emphasize the construction of later life as one of liberation, resilience and growth.
Contrasting the Functional Properties of GABAergic Axon Terminals with Single and Multiple Synapses in the Thalamus

Diverse sources of GABAergic inhibition are a major feature of cortical networks, but distinct inhibitory input systems have not been systematically characterized in the thalamus. Here, we contrasted the properties of two independent GABAergic pathways in the posterior thalamic nucleus of rat, one input from the reticular thalamic nucleus (nRT), and one “extrareticular” input from the anterior pretectal nucleus (APT). The vast majority of nRT-thalamic terminals formed single synapses per postsynaptic target and innervated thin distal dendrites of relay cells. In contrast, single APT-thalamic terminals formed synaptic contacts exclusively via multiple, closely spaced synapses on thick relay cell dendrites. Quantal analysis demonstrated that the two inputs displayed comparable quantal amplitudes, release probabilities, and multiple release sites. The morphological and physiological data together indicated multiple, single-site contacts for nRT and multisite contacts for APT axons. The contrasting synaptic arrangements of the two pathways were paralleled by different short-term plasticities. The multisite APT-thalamic pathway showed larger charge transfer during 50–100 Hz stimulation compared with the nRT pathway and a greater persistent inhibition accruing during stimulation trains. Our results demonstrate that the two inhibitory systems are morpho-functionally distinct and suggest and that multisite GABAergic terminals are tailored for maintained synaptic inhibition even at high presynaptic firing rates. These data explain the efficacy of extrareticular inhibition in timing relay cell activity in sensory and motor thalamic nuclei. Finally, based on the classic nomenclature and the difference between reticular and extrareticular terminals, we define a novel, multisite GABAergic terminal type (F3) in the thalamus.
The paucity of multimethod research: a review of the information systems literature

Abstract. It has commonly been argued that the use of different research methods within the information system (IS) discipline and within individual pieces of research will produce richer and more reliable results. This paper reports on a survey of the IS literature to discover the extent of multimethod research. The findings are that such work is relatively scarce, and where it occurs involves only a small set of traditional methods. Possible reasons for this are discussed.
Stiffness at small strain: research and practice

This paper provides the background to the 50th Rankine Lecture. It considers the growth in emphasis of the prediction of ground displacements during design in the past two decades of the 20th century, as a result of the lessons learnt from field observations. The historical development of the theory of elasticity is then described, as are the constitutive frameworks within which it has been proposed that geotechnical predictions of deformation should be carried out. Factors affecting the stiffness of soils and weak rocks are reviewed, and the results of a numerical experiment, assessing the impact of a number of stiffness parameters on the displacements around a retaining structure, are described. Some field and laboratory methods of obtaining stiffness parameters are considered and critically discussed, and the paper concludes with a suggested strategy for the measurement and integration of stiffness data, and the developments necessary to improve the existing state of the art.
Analysis of effects and pharmacokinetics of subcutaneously administered BDNF

Brain-derived neurotrophic factor (BDNF) belongs to the neurotrophin family and has been shown to be a potent and effective trophic factor for motor neurons and other neurons of the peripheral and central nervous. Little is known, however, about the relationship between the efficacy and pharmacokinetics of s.c. administered BDNF. In this study, the efficacy of BDNF on motor neuron protection in sciatic or facial nerve axotomy models was examined and compared with the concommitant concentrations of BDNF in plasma. Delayed treatment (started at 1 week after surgery) of BDNF was also shown to retard choline acetyltransferase reduction in sciatic nerve axotomy models.
Tropospheric Ozone at Northern Mid-Latitudes: Modeled and Measured Long-Term Changes

In this paper, we investigate why current state-of-the-art chemistry-climate models underestimate the tropospheric ozone increase from the 1950s to the 1990s by approximately 50%. The accuracy of these models is vital, not only for understanding and predicting air quality globally, but also since they are used to quantify the contribution of ozone in the troposphere and lower stratosphere to climate change, where its greenhouse effect is largest. We briefly describe available northern mid-latitude ozone measurements, which include representative and reliable data from European sites that extend back to the 1950s. We use the SOCOLv3 (Solar Climate Ozone Links version 3) global chemistry-climate model to investigate the individual terms of the tropospheric ozone budget. These include: inflow from the stratosphere, dry deposition, and chemical formation and destruction. For 1960 to 2000 SOCOLv3 indicates a tropospheric ozone increase at 850 hPa over the Swiss Alps (Arosa) of 17 ppb, or around 30%. This increase is smaller than that seen in the surface ozone measurements but similar to other chemistry-climate models, including those with more complex NMVOC (Non Methane Volatile Organic Compound) schemes than SOCOLv3’s. It is likely that the underestimated increase in tropospheric ozone could be explained by issues in the underlying emissions inventories used in the model simulations, with ozone precursor emissions, particularly NOx (NO + NO2), from the 1960s being too large.
Correlation Between Seminal Oxidative Stress Biomarkers and Antioxidants with Sperm DNA Damage in Elite Athletes and Recreationally Active Men

Objective To evaluate the seminal plasma 8-isoprostane, reactive oxygen species (ROS), malondialdehyde (MDA), superoxide dismutase (SOD), catalase, total antioxidant capacity (TAC), and levels of sperm DNA fragmentation in elite athletes and recreationally active men. Design Prospective design was used for this study. Setting The study was performed in the Exercise Physiology Laboratory of the Urmia University. Participants Fifty-six elite athletes and 52 recreationally active men (18–28 years) participated in this study. Intervention All subjects had a semen sampling at baseline. Main Outcome Measures Total antioxidant capacity and SOD activity were measured by colorimetric assay. Levels of ROS were measured by a chemiluminescence assay. Malondialdehyde levels were measured by thiobarbituric acid reactive substance assay. Catalase activity was measured by monitoring the initial rate of disappearance of hydrogen peroxide. Concentration of free 8-isoprostane was measured by enzyme immunoassay method. Sperm DNA fragmentation was evaluated with the terminal deoxynucleotidyl transferase–mediated fluorescein dUTP nick end-labeling assay. Results Recreationally active men have significantly higher levels of body fat, seminal SOD, TAC, and catalase and lower levels of V[Combining Dot Above]O2max, seminal ROS, MDA, and 8-isoprostane and subsequently lower rate of sperm DNA fragmentation when compared with elite athletes (P < 0.001). Significantly negative correlation was observed between sperm DNA fragmentation with body fat, seminal SOD, catalase, and TAC levels (P < 0.001). Significantly positive correlation was observed between sperm DNA fragmentation with V[Combining Dot Above]O2max, seminal 8-isoprostane, ROS, and MDA levels (P < 0.001). Conclusion Spermatozoa from recreationally active men may be less susceptible to oxidative stress–induced DNA damage and hence infertility.
Diverse proteomic alterations in gastric adenocarcinoma

Gastric adenocarcinoma is one of the most common cancers in Asian countries including China. Although its incidence rates in the West are lower than that in Asia, gastric cancer is still a major health problem worldwide, being second only to lung cancers in the number of deaths it causes. Helicobacter pylori infection has been identified as the major pathogen, but the detailed pathogenesis of gastric carcinoma remains elusive. Due to the lack of suitable and specific biomarkers for early detection, most cases of the disease are diagnosed at late stages and the survival rate is low. In this study, we used a proteomic approach to globally analyze the protein profiles of paired surgical specimens of primary gastric adenocarcinoma and nontumor mucosa aiming at identifying specific disease‐associated proteins as potential clinical biomarkers and for carcinogenetic study. Compared to nontumor tissues, multiple protein alterations were found in tumor tissues. Some of these alterations involve variations in the expression of cytoskeleton proteins, including an increase in cytokeratin 8 and tropomyosin isoform and a decrease in cytokeratin 20. Co‐up‐regulations of heat‐shock proteins and glycolytic enzymes were observed in tumor tissues, indicating self‐protective efforts of cells and the growing energy requirement during malignant transformation. Diverse regulations also occurred with proteins involved in cell proliferation and differentiation, such as GMP reductase 2 and creatine kinase B, and proteins bearing potential tumor suppressor activities, including prohibitin and selenium binding protein 1. More interestingly, a human stomach‐specific protein, 18 kDa antrum mucosa protein, was found to be dramatically under‐expressed in cancer tissues, implicating a possible special pathological role for this protein in gastric carcinogenesis. Further comprehensive evaluation by globally considering the altered factors may result in the discovery of a biomarker index for effective assessment of the disease and may provide in‐depth information for better understanding the pathogenesis of gastric cancer.