Miracle-dz/UniFAR-FTUs huggingface dataset:
Sensitivity of Hawking radiation to superluminal dispersion relations

We analyze the Hawking radiation process due to collapsing configurations in the presence of superluminal modifications of the dispersion relation. With such superluminal dispersion relations, the horizon effectively becomes a frequency-dependent concept. In particular, at every moment of the collapse, there is a critical frequency above which no horizon is experienced. We show that, as a consequence, the late-time radiation suffers strong modifications, both quantitative and qualitative, compared to the standard Hawking picture. Concretely, we show that the radiation spectrum becomes dependent on the measuring time, on the surface gravities associated with different frequencies, and on the critical frequency. Even if the critical frequency is well above the Planck scale, important modifications still show up.
Precedence-Constrained Task Allocation onto Point-to-Point Networks for Pipelined Execution

The problem of scheduling directed acyclic task flow graphs to multiprocessor systems using point-to-point networks is examined. An environment where the application has a strict throughput requirement is assumed. Pipelined parallelism is used to meet the throughput requirement. Communication and computation are completely overlapped. Each task and message has a periodic rate and deadline equal to the throughput requirement. A heuristic procedure based on preclustering, recursive mincut bipartitioning, and iterative improvement is proposed to reduce the maximum contention due to communication in the network, increasing the likelihood that messages meet their deadlines. The task assignment procedure takes into account the topology of the multiprocessor system and the distance between communicating tasks.
Effects of the calcium sensitizer OR‐1896, a metabolite of levosimendan, on post‐infarct heart failure and cardiac remodelling in diabetic Goto–Kakizaki rats

Background and purpose: Levosimendan is a novel, short half‐life calcium sensitizer used as pharmacological inotropic support in acute decompensated heart failure. After oral administration, levosimendan is metabolized to OR‐1855, which, in rats, is further metabolized into OR‐1896. OR‐1896 is a long‐lasting metabolite of levosimendan sharing the pharmacological properties of the parent compound.
Immunocytochemical evidence that collision sensing neurons in the locust visual system contain acetylcholine

The lobula giant movement detector (LGMD1 and ‐2) neurons in the locust visual system are parts of motion‐sensitive pathways that detect objects approaching on a collision course. The dendritic processes of the LGMD1 and ‐2 in the lobula are localised to discrete regions, allowing the dendrites of each neuron to be distinguished uniquely. As was described previously for the LGMD1, the afferent processes onto the LGMD2 synapse directly with each other, and these synapses are immediately adjacent to their outputs onto the LGMD2. Here we present immunocytochemical evidence, using antibodies against choline–protein conjugates and a polyclonal antiserum against choline acetyltransferase (ChAT; Chemicon Ab 143), that the LGMD1 and ‐2 and the retinotopic units presynaptic to them contain acetylcholine (ACh). It is proposed that these retinotopic units excite the LGMD1 or ‐2 but inhibit each other. It is well established that ACh has both excitatory and inhibitory effects and may provide the substrate for a critical race in the LGMD1 or ‐2, between excitation caused by edges moving out over successive photoreceptors, and inhibition spreading laterally resulting in the selective response to objects approaching on a collision course. In the optic lobe, ACh was also found to be localised in discrete layers of the medulla and in the outer chiasm between the lamina and medulla. In the brain, the antennal lobes contained neurons that reacted positively for ACh. Silver‐ or haematoxylin and eosin‐stained sections through the optic lobe confirmed the identities of the positively immunostained neurons. J. Comp. Neurol. 423:389–401, 2000. © 2000 Wiley‐Liss, Inc.
Gain of chromosome arm 9p is characteristic of primary mediastinal b‐cell lymphoma (MBL): Comprehensive molecular cytogenetic analysis and presentation of a novel MBL cell line

Primary mediastinal B‐cell lymphoma (MBL) is an aggressive Non‐Hodgkin's Lymphoma, which has been recognized as a distinct disease entity. We performed a comprehensive molecular cytogenetic study analyzing 43 MBLs. By comparative genomic hybridization (CGH), the most common aberrations were gains of chromosome arms 9p and Xq, which were present in 56% and 40% of cases, respectively. Based on the limited resolution of CGH, this technique may underestimate the real incidence of aberrations. Therefore, we also did an interphase cytogenetic study with eight DNA probes mapping to chromosome regions frequently altered in B‐cell lymphomas. With this approach, both 9p and Xq gains were found in more than 70% of cases (75% and 87%, respectively). The findings were compared with results obtained in 308 other B‐cell lymphomas. Gains in 9p were identified in only six of the 308 cases, and only one of these lymphomas with 9p gains was not primarily extranodal in origin (P < 10−20 for CGH data and P < 10−11 for fluorescence in situ hybridization data). We also present a novel MBL cell line, MedB‐1, which carries the genetic aberrations characteristic of this entity. © 2001 Wiley‐Liss, Inc.
A 9,000-year-old caribou hunting structure beneath Lake Huron

Significance Some of the most pivotal questions in human history necessitate the investigation of archaeological sites that are now under water. These contexts have unique potentials for preserving ancient sites without disturbance from later human occupation. The Alpena-Amberley Ridge beneath modern Lake Huron in the Great Lakes offers unique evidence of prehistoric caribou hunters for a time period that is very poorly known on land. The newly discovered Drop 45 Drive Lane and associated artifacts presented here provide unprecedented insight into the social and seasonal organization of early peoples in the Great Lakes region, while the interdisciplinary research program provides a model for the archaeological investigation of submerged prehistoric landscapes. Some of the most pivotal questions in human history necessitate the investigation of archaeological sites that are now under water. Nine thousand years ago, the Alpena-Amberley Ridge (AAR) beneath modern Lake Huron was a dry land corridor that connected northeast Michigan to southern Ontario. The newly discovered Drop 45 Drive Lane is the most complex hunting structure found to date beneath the Great Lakes. The site and its associated artifacts provide unprecedented insight into the social and seasonal organization of prehistoric caribou hunting. When combined with environmental and simulation studies, it is suggested that distinctly different seasonal strategies were used by early hunters on the AAR, with autumn hunting being carried out by small groups, and spring hunts being conducted by larger groups of cooperating hunters.
Reliability of the dye penetration studies.

The purpose of this study was to compare the classical dye-penetration method to a dye-extraction method, with a fluid-filtration method as control. Forty teeth were prepared with a ProFile device and divided into four groups (n = 10 per group) according to the sealer used for the lateral condensation: Pulp Canal Sealer, Sealapex, AH Plus, and Ketac-Endo. The apical seal was evaluated on the same teeth with all three methods, successively: a fluid-filtration method, a dye-penetration method with 2% methylene blue, and a new method where the roots were dissolved in 65% nitric acid to extract the methylene blue before reading the absorbance of the solution. The classical dye penetration did not show any difference among the sealers and showed no correlation with the two other techniques. The fluid filtration (p < 0.01) and the dye extraction (p < 0.01) showed that Sealapex displayed the highest apical leakage. The correlation between the results obtained with these two methods was significant (p = 0.001 and r = 0.7). This study showed the limitation of the classical dye-penetration studies and that the dye-extraction, i.e. dissolution, method gave the same results as fluid filtration but saved much laboratory time.
Occupational Stress of Higher Secondary Teachers Working in Vellore District

This study examined the Occupational Stress of teachers working at higher secondary level. Three Hundred and Twenty Seven higher secondary teachers from Vellore District in Tamil Nadu were chosen as sample, by using Simple Random Sampling Technique and administered with an Occupational Stress Rating Scale. The statistical techniques employed were percentage, mean, SD, mean ± 1SD, t-test, F-test, and stepwise multiple regression analysis and the obtained results are analyzed accordingly. To overcome occupational stress, the researchers have suggested some measures which could prove beneficial to teachers in coping with stress are: improve self esteem, build self confidence, work on building emotional intelligence competencies, develop a good sense of humour, practice yoga and meditation, exercise regularly, foster a supportive friend circle, cultivate hobbies, develop effective communication skills, and seek professional help, if necessary.
A method for assessing the software engineering capability of contractors

This document provides guidelines and procedures for assessing the ability of potential DoD contractors to develop software in accordance with modem software engineering methods. It includes spl-:ific questions and a method for evaluating the results. ,I General Introduction The purpose of this document is to facilitate objective and consistent assessments of the ability of potential DoD contractors to dovelop software in accordance with modem software engineering methods. Such assessments would be conducted either In the pre-solicitation qualification process, in the formal source selection process, or both. While this doc~ument Is Intended to guide the assessment of a contractor's overall software engineering capability, it can also be valuable in the assessment . ", a specific project team's software engineering capability. Alternatively, this document can be used as an aid to software development organizations in conducting an internal as issment cf their own softvare engineering capability. The document is designed to help An assessment team define the highest priorldy steps for the Improvement of an organization's capability. Because an understanding of proper software engineering practice is only now developing, standard, well-accepted measures do not yet exist. The assessment questions listed in the body of this . )•cum,'nt are phrased so that an affirmative answer indicates that an organization has a desirable characteristic. Some of the questions pertain to advanced concepts of software engineering that may not yet be sufficiently refined or disseminated to be incorporated in a contractor's standard practice; therefore, not all assessment questions need be answered affirmatively for an organization to be considered to have a modern software engineering capability. The capability of a contractor to perform software engineering has been divided into three areas: 1. organization and resource management 2. software engine. )rlng process and its management 3. tools and technology. The qualities that the questions assess are different for each of these areas acnd are described in the introductions to the questions for each area. 093087 SEt Assessment Methodology A full assessment of software engineering capability' Includes some evaluation of the experience level of the software development personnel. Addendum A contains suggested questions for use In this evaluation.
Preclinical study of Ublituximab, a Glycoengineered anti-human CD20 antibody, in murine models of primary cerebral and intraocular B-cell lymphomas.

PURPOSE Primary cerebral lymphoma (PCL) and primary intraocular lymphoma (PIOL) belong to the systemic diffuse large B-cell lymphoma family and are characterized by the presence of CD20(+) lymphoma B cells in the brain or the eye. These highly aggressive malignancies have a poor prognosis and no specific therapy. The presence of effector immune cells in the damaged brain and vitreous suggests that treatment with anti-human CD20 (hCD20) monoclonal antibodies might be effective. We developed murine models of PCL and PIOL to assess the intracerebral and intraocular antitumor effect of ublituximab, a promising glycoengineered anti-hCD20 mAb with a high affinity for FcγRIIIa (CD16) receptors. METHODS The murine lymphoma B-cell line A20.IIA-GFP-hCD20 (H-2(d)) was injected into the right cerebral striatum or the vitreous of immunocompetent adult BALB/c mice (H-2(d)). Four to 7 days later, ublituximab was injected intracerebrally or intravitreously into the tumor site. Rituximab was the reference compound. Survival was monitored for injected mice; histopathological and flow cytometric analyses were performed to study tumor growth and T-cell infiltration. RESULTS Single doses of ublituximab, injected intracerebrally or intravitreously, had a marked antitumor effect, more pronounced than that obtained with the same dose of rituximab in these conditions. The reduction in tumor cells was correlated with an increased proportion of CD8(+) T cells. This efficacy was observed only against lymphoma B cells expressing hCD20. CONCLUSIONS These in vivo results confirm the potential of the glycoengineered anti-hCD20 mAb ublituximab as an innovative therapeutic approach to treat primary central nervous system lymphoma and other B-cell lymphomas.
The utilization of the energy of two mixtures of steam-volatile fatty acids by fattening sheep

The energy of mixtures of steam-volatile fatty acids representative of those arising in the rumen when food undergoes microbial fermentation was utilized with high efficiency when given to fasting sheep, and was unaffected by the molar composition of the mixtures employed (Armstrong, Blaxter & Graham, 1957). Given as the sole source of energy, however, acetic acid was poorly utilized (Armstrong & Blaxter, 1957U). It was shown later that when the acids were added singly to rations which themselves permitted a retention of energy, the individual acids were utilized for lipogenesis with much lower efficiencies than in the fasting animal and marked differences in the utilization of the individual acids were found (Armstrong & Blaxter, 19573). It was therefore important to establish whether different mixtures of the steam-volatile acids are utilized with constant efficiency when they are given to fattening animals. The experiments described below were designed for this purpose.
Developing a Set of Core Outcomes for Trials in Hemodialysis: An International Delphi Survey.

BACKGROUND Survival and quality of life for patients on hemodialysis therapy remain poor despite substantial research efforts. Existing trials often report surrogate outcomes that may not be relevant to patients and clinicians. The aim of this project was to generate a consensus-based prioritized list of core outcomes for trials in hemodialysis. STUDY DESIGN In a Delphi survey, participants rated the importance of outcomes using a 9-point Likert scale in round 1 and then re-rated outcomes in rounds 2 and 3 after reviewing other respondents' scores. For each outcome, the median, mean, and proportion rating as 7 to 9 (critically important) were calculated. SETTING & PARTICIPANTS 1,181 participants (202 [17%] patients/caregivers, 979 health professionals) from 73 countries completed round 1, with 838 (71%) completing round 3. OUTCOMES & MEASUREMENTS Outcomes included in the potential core outcome set met the following criteria for both patients/caregivers and health professionals: median score ≥ 8, mean score ≥ 7.5, proportion rating the outcome as critically important ≥ 75%, and median score in the forced ranking question < 10. RESULTS Patients/caregivers rated 4 outcomes higher than health professionals: ability to travel, dialysis-free time, dialysis adequacy, and washed out after dialysis (mean differences of 0.9, 0.5, 0.3, and 0.2, respectively). Health professionals gave a higher rating for mortality, hospitalization, decrease in blood pressure, vascular access complications, depression, cardiovascular disease, target weight, infection, and potassium (mean differences of 1.0, 1.0, 1.0, 0.9, 0.9, 0.8, 0.7, 0.4, and 0.4, respectively). LIMITATIONS The Delphi survey was conducted online in English and excludes participants without access to a computer and internet connection. CONCLUSIONS Patients/caregivers gave higher priority to lifestyle-related outcomes than health professionals. The prioritized outcomes for both groups were vascular access problems, dialysis adequacy, fatigue, cardiovascular disease, and mortality. This process will inform a core outcome set that in turn will improve the relevance, efficiency, and comparability of trial evidence to facilitate treatment decisions.
Functional production and reconstitution of the human equilibrative nucleoside transporter (hENT1) in Saccharomyces cerevisiae. Interaction of inhibitors of nucleoside transport with recombinant hENT1 and a glycosylation-defective derivative (hENT1/N48Q).

We have produced recombinant human equilibrative nucleoside transporter (hENT1) in the yeast Saccharomyces cerevisiae and have compared the binding of inhibitors of equilibrative nucleoside transport with the wild-type transporter and a N-glycosylation-defective mutant transporter. Equilibrium binding of 3H-labelled nitrobenzylmercaptopurine ribonucleoside {6-[(4-nitrobenzyl)thio]-9-beta-d-ribofuranosyl purine; NBMPR} to hENT1-producing yeast revealed a single class of high-affinity sites that were shown to be in membrane fractions by (1) equilibrium binding (means+/-S.D.) of [3H]NBMPR to intact yeast (Kd 1.2+/-0.2 nM; Bmax 5.0+/-0.5 pmol/mg of protein) and membranes (Kd 0.7+/-0.2 nM; Bmax 6.5+/-1 pmol/mg of protein), and (2) reconstitution of hENT1-mediated [3H]thymidine transport into proteoliposomes that was potently inhibited by NBMPR. Dilazep and dipyridamole inhibited NBMPR binding to hENT1 with IC50 values of 130+/-10 and 380+/-20 nM respectively. The role of N-linked glycosylation in the interaction of NBMPR with hENT1 was examined by the quantification of binding of [3H]NBMPR to yeast producing either wild-type hENT1 or a glycosylation-defective mutant (hENT1/N48Q) in which Asn-48 was converted into Gln. The Kd for binding of NBMPR to hENT1/N48Q was 10. 5+/-1.6 nM, indicating that the replacement of an Asn residue with Gln decreased the affinity of hENT1 for NBMPR. The decreased affinity of hENT1/N48Q for NBMPR was due to an increased rate of dissociation (koff) and a decreased rate of association (kon) of specifically bound [3H]NBMPR because the values for hENT1-producing and hENT1/N48Q-producing yeast were respectively 0.14+/-0.02 and 0. 36+/-0.05 min-1 for koff, and (1.2+/-0.1)x10(8) and (0.40+/-0. 04)x10(8) M-1.min-1 for kon. These results indicated that the conservative conversion of an Asn residue into Gln at position 48 of hENT1 and/or the loss of N-linked glycosylation capability altered the binding characteristics of the transporter for NBMPR, dilazep and dipyridamole.
Identification of Genes Selectively Regulated in Human Hepatoma Cells by Treatment With Dyslipidemic Sera and PUFAs

Serum composition is linked to metabolic diseases not only to understand their pathogenesis but also for diagnostic purposes. Quality and quantity of nutritional intake can affect disease risk and serum composition. It is then possible that diet derived serum components directly affect pathogenetic mechanisms. To identify involved factors, we evaluated the effect on gene expression of direct addition of dyslipidemic human serum samples to cultured human hepatoma cells (HepG2). Sera were selected on the basis of cholesterol level, considering this parameter as mostly linked to dietary intake. Cells were treated with 32 sera from hypercholesterolemic and normocholesterolemic subjects to identify differentially regulated mRNAs using DNA microarray analysis. We identified several mRNAs with the highest modulations in cells treated with dyslipidemic sera versus cells treated with normal sera. Since the two serum groups had variable polyunsaturated fatty acids (PUFAs) contents, selected mRNAs were further assessed for their regulation by docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA) and arachidonic acid (AA). Four genes resulted both affected by serum composition and PUFAs: 3‐hydroxy‐3‐methylglutaryl‐CoenzymeA synthase 2 (HMGCS2), glutathione S‐transferase alpha 1 (GSTA1), liver expressed antimicrobial peptide 2 (LEAP2) and apolipoprotein M (ApoM). HMGCS2 expression appears the most relevant and was also found modulated via transcription factors peroxysome proliferator activated receptor α (PPARα) and forkhead box O1 (FoxO1). Our data indicate that expression levels of the selected mRNAs, primarily of HMGCS2, could represent a reference of nutritional intake, PUFAs effects and dyslipidemic diseases pathogenesis. J. Cell. Physiol. 230: 2059–2066, 2015. © 2015 Wiley Periodicals, Inc.
A Dictionary of English Place-Names

From Abbas Combe to Zennor, this "Dictionary of English Place-Names" gives the meaning and origin of over 12,000 place-names, tracing their development from earliest times to the present day. A reference for the tourist or local historian, it should also be of value to anyone interested in the names of English towns and villages. For this second edition 300 new entries have been added, many existing entries have been expanded, and the county boundary changes of 1996 have been incorporated. A glossary of common elements in English place-names and an extensive bibliography are also included.
Control of penetration and mixing of an excited supersonic jet into a supersonic cross stream

Rayleigh/Mie scattering (from flow-field ice crystals) was used to study mixing and penetration of a forced supersonic jet in a supersonic Mach (M)-2 cross stream. Instantaneous images—using image planes along (side-view) and normal (end-view) to the flow axis—were used to study the dynamical structures in the jet whereas ensemble images provide information regarding the jet trajectory. Standard deviation images reveal information about the large-scale mixing/entrainment. Probability density functions were used to evaluate the mixing along the time-average jet interface. Forced cases indicate the presence of periodic formation of large-scale eddies in the jet/free stream interface. The eddies were bigger in size and more convoluted in the forced cases as compared to the baseline. These provided high penetration of the jet into the free stream. Forced cases also show a larger region involved in small scale and/or bulk mixing in both the side—and end-views. Different metrics such as total area contained in .