Miracle-dz/UniFAR-FTUs huggingface dataset:
Both macrophages and hypoxia play critical role in regulating invasion of gastric cancer in vitro

Abstract Background. As previously demonstrated, tumor associated macrophages (TAMs) infiltration is associated with some cancers invasion and metastasis. However, the role of TAMs in the gastric cancer remains unclear. Methods Three- dimensional dynamic migration imaging system and real time RT-PCR were used to quantitatively investigate the effect of macrophages on the cancer cell mobility and gene expression related to cancer invasion and metastasis, including ADAM8, ADAM9, MMP9, TIMP3, VEGF-A and IL8 genes, in AGS, HGC-27, Hs-746T and NCI-N87 gastric cancer cell lines under normal or hypoxic conditions. Results. Under normal conditions, the cancer cell invasion rate was increased significantly and all six gene expressions were upregulated in all four cancer cell lines by macrophages. Under hypoxia the changes in the cancer cell invasion rate induced by macrophages was negatively correlated to the TIMP3 expression. In non- metastatic cell line AGS, the increase in migration rate induced by macrophages was further elevated under hypoxia with increased ADAM8 and ADAM9 expression and decreased MMP9 and TIMP3 expressions. Under hypoxia, the induction by macrophages for IL-8 expression was increased significantly in distant metastatic cell lines NCI-N87 and HS-746T, VEGF-A was increased in HGC-27 cell line. Conclusions. Both macrophages and hypoxia play an indispensable role in regulating the invasion of gastric cancer cells in vitro; ADAMs, MMP9 and TIMP3 might be involved in TAM induced invasive power of gastric cancer cells.
Anchoring Bias in Consensus Forecasts and Its Effect on Market Prices

Abstract Previous empirical studies on the “rationality” of economic and financial forecasts generally test for generic properties such as bias or autocorrelated errors but provide only limited insight into the behavior behind inefficient forecasts. This paper tests for a specific form of forecast bias. In particular, we examine whether expert consensus forecasts of monthly economic releases are systematically biased toward the value of previous months’ releases. Such a bias would be consistent with the anchoring and adjustment heuristic described by Tversky and Kahneman (1974) or could arise from professional forecasters’ strategic incentives. We find broad-based and significant evidence for this form of bias, which in some cases results in sizable predictable forecast errors. To investigate whether market participants’ expectations are influenced by this bias, we examine interest rate reactions to economic news. We find that bond yields react only to the residual, or unpredictable, component of the forecast error and not to the component induced by anchoring, suggesting that expectations of market participants anticipate this bias embedded in expert forecasts.
Changes in ownership forms and role of institutional investors in governing public companies in Malaysia

Purpose – The purpose of this paper is to ascertain whether different types of institutional investor in Malaysia are involved in the corporate governance of their investee companies, and, if yes, to what extent is the level of the involvement. Design/methodology/approach – A qualitative approach, consisting of a series of interviews with 18 senior investment managers of different types of institutional investor, was chosen. Findings – The findings suggest that lessons learnt from the fallout of the Asian crisis has made Malaysian institutional investors not only to be more prudent in managing their total funds and in making equities investment decisions, but has resulted in a more active participation in their “core” investee companies apart from merely discharging their voting rights. Interview analysis revealed that government-linked investment companies are championing the cause and could possibly affect the overall level of institutional investors’ involvement, which bode well for the future of the c.
Erythrocyte Osmotic Fragility of Nera Black Fowls of Two - Age Groups

The erythrocyte osmotic fragility and other erythrocyte indices in fowls of two different age groups (7-9 week-old and 49 week-old) were studied using Nera Black strain usually raised commercially for egg production in Nigeria. Erythrocytes in the 49 week-old birds were more fragile than those in the 7-9 week-old at sodium chloride (NaCl) concentrations of 0.2% (p<0.05), 0.7% (p<0.05), 0.8% (p<0.01) and 0.9% (p<0.01). The mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCH) values were also higher in the adults, but the packed cell volume (PCV) was lower. The haemoglobin (Hb) concentration, red blood cell (RBC) count and mean corpuscular volume (MCV) were similar in the two age groups.
Coordination and costly preference elicitation in electronic markets

Electronic markets are based on classic market design assumptions that often do not hold. This thesis examines the conflict between theory and practice for the class of Vickrey-Clarke-Groves mechanisms (VCG) and the auctions it has inspired in electronic commerce, most notably the iterative auctions found on eBay. VCG mechanisms provide bidders with an optimal strategy to truthfully reveal their valuations to the marketplace, and in so doing VCG mechanisms enable efficient allocations of goods. VCG assumes not only that consumers are able to coordinate themselves to a single market and moment in time when conducting their transactions, but also that consumers can determine and express their valuations at no cost. However, in systems like eBay, bidders and sellers are highly uncoordinated, and the market is iterative because consumers are often assumed in practice not to have a complete sense of their valuation initially, but to incur costs in order to derive better beliefs of their value. The theory-practice conflict is investigated through analytic and empirical analyses of three facets of markets and consumers with independent, private valuations. First, an analysis of 1,956 auctions on eBay for a Dell E193FP LCD monitor reveals the extent to which bidders on eBay are successfully handling their lack of coordination, and the extent to which their inability to behave optimally is hampering the efficiency of eBay. Many bidders may be experiencing regret with efficiency hampered by as much as 7% as a result. Second, the design of a marketplace for uncoordinated consumers is given that provides consumers with an optimal bidding strategy to truthfully reveal their valuation to a bidding proxy. A simulation study demonstrates that this novel marketplace provides greater efficiency than eBay, while also increasing seller revenue. Finally, the efficiency of the Iterative Combinatorial Exchange (ICE), designed to accommodate bidders with costly value refinement, is compared to that of a sealed-bid VCG-based marketplace, where the amount of value refinement available to bidders is limited. ICE provides more efficient results, but not dramatically so as compared to the VCG-based market.
Cents or Percent? The Effects of Promotion Framing on Price Expectations and Choice

Previous research has shown that the monetary value of a promotion (promotion depth) affects choice during the promotion period. However, as promotion depth increases, consumers might lower their expectations of future price, which in turn may threaten future choice when prices return to normal levels. This research examines how promotion frame (percentage off versus cents off) moderates the effect of promotion depth on postpromotion price expectations and choice. The findings indicate that compared with cents-off promotions, high-depth percentage-off promotions lead to higher postpromotion price expectations. Likewise, postpromotion choice is higher when high-depth promotions are framed in percentage-off than cents-off terms. The authors examine the process underlying the effect of promotion frame on price expectations and find that frame affects (1) consumers' perceptions of the promoted price and (2) the weight they place on the promoted price.
ORGANIZING FOR PROFESSIONAL LEARNING COMMUNITIES: EMBEDDING PROFESSIONAL LEARNING DURING THE SCHOOL DAY

This case study presents the struggles faced by a school administration in implementing a professional learning community (PLC) initiative without additional funds earmarked for implementation. In this case, Emily, the principal of Bayside Public School, creates a Buddy Day system for students that provides teachers with time during the school day to meet for PLCs; however, tensions among the principals, teachers, parents, and union guidelines arise. The teaching notes section explores other readings about professional development, the viewpoints of the various stakeholders in the case, and provincial documents about the implementation of PLCs.
Visitors’ brand loyalty to a historical and cultural theme park: a case study of Hangzhou Songcheng, China

Conducting research on the factors affecting brand loyalty to theme parks is an important method for enhancing brand loyalty among tourists. This paper takes the Hangzhou Songcheng historical and cultural theme park as a case study. Hypotheses are proposed and structural equation model is constructed based on tourist perception theory. Findings show that theme park brand satisfaction is related to brand loyalty through brand attachment and historical and cultural performance. The quality of facilities and attractions has no significant correlation with perceived value and brand satisfaction. The service quality of attendants also has no significant correlation with tourist perceived value.
Environmental Movements in Advanced Industrial Democracies: Heterogeneity, Transformation, and Institutionalization

Environmental movements are networks of informal interactions that may include individuals, groups, and organizations engaged in collective action motivated by shared identity or concern about environmental issues. This article reviews literature on environmental movements (including antinuclear energy movements) according to four main aspects: the social bases and values underlying the movements' mobilization, the resources supporting their mobilization, the political opportunities channeling their mobilization, and the cultural framing processes through which environmental issues are defined as social and political problems to be addressed through mobilization. In addition, we consider the historical antecedents and roots of environmental movements. Finally, we discuss the interplay between the local and the global levels and the movements' impacts, a long neglected issue in the social movement literature. Our review highlights three main features of environmental movements: they are heterogeneous; they.
Pseudomonas rhizosphaerae sp. nov., a novel species that actively solubilizes phosphate in vitro.

A bacterial strain (designated IH5(T)), isolated from rhizospheric soil of grasses growing spontaneously in Spanish soil, actively solubilized phosphates in vitro when bicalcium phosphate was used as a phosphorus source. This strain was Gram-negative, strictly aerobic, rod-shaped and motile. The strain produced catalase, but not oxidase. Cellulose, casein, starch, gelatin, aesculin and urea were not hydrolysed. Growth was observed with many carbohydrates as the carbon source. The main non-polar fatty acids detected were hexadecenoic acid (C(16 : 1)), hexadecanoic acid (C(16 : 0)) and octadecenoic acid (C(18 : 1)). The hydroxy fatty acids detected were 3-hydroxydecanoic acid (C(10 : 0) 3-OH), 3-hydroxydodecanoic acid (C(12 : 0) 3-OH) and 2-hydroxydodecanoic acid (C(12 : 0) 2-OH). Phylogenetic analysis of 16S rRNA indicated that this bacterium belongs to the genus Pseudomonas in the gamma-subclass of the Proteobacteria and that the closest related species is Pseudomonas graminis. The DNA G+C content was 61 mol%. DNA-DNA hybridization showed 23 % relatedness between strain IH5(T) and P. graminis DSM 11363(T). Therefore, strain IH5(T) belongs to a novel species from the genus Pseudomonas, for which the name Pseudomonas rhizosphaerae sp. nov. is proposed (type strain, IH5(T)=LMG 21640(T)=CECT 5726(T)).
Will the ship energy efficiency management plan reduce CO2 emissions? A comparison with ISO 50001 and the ISM code

The Ship Energy Efficiency Management Plan (SEEMP) is the sole international regulatory instrument expected to affect rising CO2 emissions from shipping in the short-term. In this article, we discuss present gaps in the SEEMP guidelines through a comparison with the international standard for energy management systems (EMS), ISO 50001, and with the International Safety Management (ISM) code, which sets requirements for safety management systems in shipping companies. We show that the SEEMP lacks crucial features found in typical management system standards, such as requirements on policy and management reviews. Moreover, best-practice in the form of the ISO 50001 addresses important aspects, such as monitoring, energy auditing, design, and procurement processes in much more detail. In the context of previous research on these instruments and on energy efficiency in general, we argue that these gaps may be detrimental to the success of the SEEMP, both from the societal perspective of CO2 abatement and from the perspective of companies’ success in energy management. This requires further attention by academia, policy-makers and industry.
Determinants of profitability in European manufacturing and services: evidence from a dynamic panel model

Recent advances in panel data econometrics are used to investigate the determinants of profitability for manufacturing and service sector firms in Belgium, France, Italy and the UK, for the period 1993–2001. The paper synthesizes empirical models that have been used by researchers in industrial economics, strategic management and accounting and finance. Despite the formation of the European Union's Single Market in goods and services, abnormal profit still appears to persist significantly from year to year. There is evidence of a negative size-profitability relationship, but the relationship between market share and profitability is positive, and stronger in manufacturing than in services. The relationship between a firm's gearing ratio and its profitability is negative, but firms with higher liquidity tend to be more profitable.
The Educated Russian's Curse: Returns to Education in the Russian Federation During the 1990s

This paper uses a representative sample of the Russian Federation, the Russian Longitudinal Monitoring Survey, to estimate the returns to education in this ex-communist country. We tackle this classic issue in labor economics with the realistic expectation of obtaining results for Russia comparable in quality and reliability to those available in developed countries and other economies in transition. Using standard regression techniques we find that the returns to education in Russia are quite low compared with those reported in the literature on countries throughout the world, in almost no specification reaching higher than 5 per cent. Moreover, there is virtually no improvement in returns to education in the 1992-99 period, a result somewhat at odds with other studies using Russian data from similar time periods. When we instrument our main regressor using policy experiments from the 1960s, we find comparable results. We also perform a selectivity correction and discover even lower returns to education for men, although they become slightly higher for women. Additionally, we find extremely low returns to tenure, which can even become negative in certain specifications.
Mammographic, US, and MR imaging phenotypes of familial breast cancer.

PURPOSE To prospectively investigate the imaging (mammographic, ultrasonographic [US], magnetic resonance [MR] imaging) features of invasive and intraductal breast cancers in women at familial risk. MATERIALS AND METHODS Ethics committee approval and informed consent were obtained. Breast cancers were identified in women at moderately increased risk, in women at high familial risk, and in documented BRCA1 and BRCA2 mutation carriers. All cancers were investigated with mammography, US, and bilateral dynamic breast MR imaging. Imaging findings of breast cancer in women in the different risk categories were prospectively collected and compared. With the two-sample Wilcoxon signed rank test, imaging features of cancers were compared. RESULTS Seventy-six breast cancers were identified in 68 women (mean age, 41.3 years). Mammographic breast density had no influence on detectability of cancers. Imaging phenotypes differed among risk categories: 15 (23%) of 64 invasive cancers appeared as fibroadenoma-like masses without calcifications but without fibroadenoma-like internal enhancement or enhancement kinetics at breast MR imaging. Of those, 12 (80%) occurred in women at high risk and documented BRCA1 mutation carriers. A posterior (immediately prepectoral) location was observed in 67% (32 of 48) of all breast cancers in women at high risk and mutation carriers (P < .009). None of the remaining BRCA1-associated invasive cancers exhibited calcifications; intraductal cancers were not observed. In 28 cancers in BRCA2 carriers or women at moderately increased risk, imaging features seemed equivalent to those reported for sporadic cancers; cases of ductal carcinoma in situ were observed, and there was no preference for a posterior location in the breast. At MR imaging, a high percentage (20% [13 of 64]) of invasive cancers appeared as non-masslike enhancement; benign kinetic features were observed in 33% (25 of 76). CONCLUSION Imaging phenotypes of cancers differ among risk categories. If MR imaging is used for screening, high sensitivity rates are achievable only if morphologic and kinetic features are assessed and if non-masslike enhancement is considered. Lesion location is important in regard to malignancy. SUPPLEMENTAL MATERIAL http://radiology.rsnajnls. org/cgi/content/full/246/1/58/DC1.
The Political Economy of Addressing the Climate Crisis in the Earth System: Undermining Perverse Resilience

The Earth system is a complex adaptive system, characterised by non-linear change and with significant capacity for surprise. In times of systemic crisis, such as dangerous anthropogenic climate change, perverse resilience (for example the structural power of fossil fuel interests in the global economy) can threaten overall Earth system stability. Critical political economic analysis recognises climate change as a threat with significant political economic characteristics and implications. However, key dimensions of climate change as a globally coherent phenomenon, including the important implications of Earth system dynamism and non-linear change, can remain unrecognised, mischaracterised or underestimated. In contrast, resilience approaches describe social-ecological systems but neglect the significance of norms and power relations in human societies. This article builds theory by linking key concepts – hegemony and resilience – from neo-Gramscian political economic analysis and resilience approaches to social-ecological systems. Our objective is to generate a new conceptual framework to improve understanding of the role of politics in social-ecological systems. We use climate change and its mitigation to demonstrate the new framework's potential.
Combination therapy with efavirenz, nelfinavir, and nucleoside reverse-transcriptase inhibitors in children infected with human immunodeficiency virus type 1. Pediatric AIDS Clinical Trials Group 382 Team.

BACKGROUND Consistent long-term viral suppression has been difficult to achieve in children with human immunodeficiency virus type 1 (HIV-1) infection. We tested the safety and antiviral efficacy of a novel combination consisting of efavirenz, nelfinavir, and one or more nucleoside reverse-transcriptase inhibitors in 57 children previously treated with only nucleoside reverse-transcriptase inhibitors. METHODS The children were monitored for 48 weeks after the initiation of therapy. We assessed plasma concentrations of efavirenz and nelfinavir, plasma HIV-1 RNA levels, and lymphocyte subpopulations. RESULTS At base line, the 57 HIV-1-infected children (age range, 3.8 to 16.8 years) had a median of 699 CD4 cells per cubic millimeter and 10,000 copies of HIV-1 RNA per milliliter of plasma. The most common treatment-related effects of at least moderate severity were rash (in 30 percent of children), diarrhea (in 18 percent), neutropenia (in 12 percent), and biochemical abnormalities (in 12 percent). Serious side effects were uncommon. The mean values for the area under the curve for efavirenz and nelfinavir corresponded to expected values. In an intention-to-treat analysis, 76 percent of children had plasma HIV-1 RNA levels of less than 400 copies per milliliter after 48 weeks of therapy and 63 percent had levels of less than 50 copies per milliliter. A high plasma HIV-1 RNA level at base line significantly decreased the likelihood that plasma levels of HIV-1 RNA would become undetectable during treatment. CONCLUSIONS In HIV-1-infected children who were previously treated with nucleoside reverse-transcriptase inhibitors, the combination of efavirenz, nelfinavir, and nucleoside reverse-transcriptase inhibitors was generally well tolerated and had a potent and sustained antiviral effect.
The smile of the tourist: the relationship between price sensitivity and expenses

The objective of this study is to test the effect of individual price sensitivity on holiday expenses. In the context of tourism, in such a markedly heterogeneous market, the great diversity of sensitivities to price leads the role it plays to become especially complex. Analysis of price sensitivity allows the analyst to observe how a tourist reacts when facing different product prices and, on the other hand, understanding the determinant factors of holiday expenses is crucial for organizations and destinations to implement their strategies. The methodology applied estimates random coefficient logit models that consider tourist heterogeneity. The empirical application carried out on a sample of 2127 individuals shows that price sensitivity has a non-linear influence on holiday expenditures, drawing a curious smile-shaped effect. The differentiated effect found for price sensitivities has important implications for management, as it confirms the existence of a great diversity of price sensitivities in the market. Therefore, knowing the individual by individual preference structure in terms of prices allows the pricing of the service to each individual (though extreme, it could be possible), as well as the formation of groups of individuals with similar price preferences. This price discrimination is particularly important in that it is based on the preferences of individual people. The estimation of the individual parameters of the utility function of each individual is crucial for management as it reveals consumers’ preference structure and information on each individual is obtained. At a time when individuals are increasingly demanding and insist on service provision adapted to their specific needs, knowledge of the profile of each consumer allows organizations to offer the most suitable services.
Beyond 'Euroland': British Trade Unions, the Single Currency and European Integration

British trade unions have differing perspectives as to the desirability of UK membership of the eurozone. This paper provides a critical review of the spectrum of union views and highlights key points of disagreement and areas of common ground. An agenda for further reflection upon the euro by the unions is also offered. Finally, the paper considers union positions on the implications of the wider process of European integration for industrial relations.