Miracle-dz/UniFAR-FTUs huggingface dataset:
Association between parents’ attitudes and behaviors toward children's visual care and myopia risk in school-aged children

Abstract The purpose of this survey was to determine the association of parents’ attitudes and behaviors toward children's visual care with myopia risk in school-aged children. A total of 894 parents of school-aged children were investigated in primary and middle schools in the central and noncentral urban area in Wuhan through stratified cluster random sampling on July, 2015. We analyzed the association by the generalized linear mixed model. The results indicated that children with parents’ high expectations of 1.5 or higher on their vision exhibited a decreased risk of myopia compared with 1.0 and 0.5 or lower (OR = 0.49, 95%CI = 0.36–0.67). Children whose parents only paid attention to their vision in junior and senior school and in primary school had an increased myopia risk than that in preschool (OR = 2.12, 95%CI = 1.01–4.45, and OR = 3.11, 95%CI = 1.28–7.58, respectively). Children whose parents ensured for their sufficient sleep had a decreased myopia risk (OR = 0.45, 95%CI = 0.24–0.85). Compared with children whose parents who never adjusted electronic devices’ parameters, the odds ratio of sometimes was 0.49 (95%CI = 0.31–0.79), often 0.53 (95%CI = 0.33–0.85), and always 0.44 (95%CI = 0.26–0.75), respectively. Parents’ attitudes and behaviors toward children's visual care are significantly associated with the myopia risk in school-aged children. Consequently, efforts should be made to educate parents on how they protect children's vision and reduce their risk of myopia.
In vitro Fluoride Uptake by Intra–Orally Aged and Contaminated Glass Ionomer Cement

release can be elevated by repeated exposure of the glass ionomer restorations to high doses of fluoride. Several reports have described such ‘recharging’ in vitro by treatment of glass ionomer samples with NaF solutions of various concentrations [Forsten, 1991, 1995; Takahashi et al., 1993; Creanor et al., 1994; Hatibovic-Kofman et al., 1997b] or with a fluoridated gel [Seppä et al., 1995]. In a previous in vitro study [Damen et al., 1996], we found that the uptake of fluoride by aged glass ionomer cement is partly inhibited following pre-incubation in saliva. It is not unlikely that during a long period in the mouth, salivary and plaque-derived compounds adsorb to the surface of glass ionomer restorations and block the inward (and outward) diffusion pathways. The aim of this study was to determine the effect of such contamination on the uptake of fluoride. To this end, discs of glass ionomer cement with one surface exposed were placed in the partial prostheses of a group of panelists during a period of 3 months. After retrieval from the mouth, the discs were incubated in a concentrated NaF solution and the subsequent fluoride release was determined and compared with fluoride release from control discs exactly as described previously [Damen et al., 1996]. Fuji Lining LC (GC International Corp., Tokyo, Japan) was chosen as the test material, because its easy handling facilitated reproducible experimental conditions. Similar fluoride uptake and release characteristics have been reported for this and restorative (type II) glass ionomer cements [Takahashi et al., 1993]. Discs 5.0 mm in diameter and about Short Communication
Quantitative Detection of Human Complement Factor H-Related Protein in Transitional Cell Carcinoma of the Urinary Bladder

Objective: The purpose of this study was to assess a new quantitative urinary tumor marker for transitional cell carcinoma of the urinary bladder (TCC), human complement factor H-related protein (hCFHrp, BTA TRAKTM). Methods: Urine samples of 298 individuals (76 healthy volunteers, 118 patients with benign urologic disorders, 104 patients with histologically proven bladder cancer) were examined for the presence of hCFHrp. Samples of all patients were obtained prior to therapy. Results: In comparison to healthy volunteers, patients with TCC had significantly higher urinary levels of hCFHrp (117.60 vs. 2.05 U/ml; p < 0.001). HCFHrp levels were positively correlated with tumor grade and stage. Patients with invasive TCC had significantly higher levels of hCFHrp than patients with superficial TCC (p = 0.001). Marker levels in superficial bladder cancer at high risk of tumor progression (pT1G3) were significantly higher as compared to low and intermediate grade superficial cancers. Elevated levels of hCFHrp were also found in patients with benign urologic disorders (median: 72.65 vs. 117.60 U/ml in cancer patients). Using a cutoff of 17.1 U/ml, hCFHrp had a sensitivity of 72.1% and, due to a high rate of false-positive determinations in patients with benign urologic disorders, a total specificity of 50.5%. Conclusions: HCFHrp (BTA TRAKTM) is a sensitive test for detection of bladder cancer and for identification of patients at high risk. Due to a high rate of false-positive results in patients with benign urologic diseases, the test should not be used in an unselected population.
Tumor-associated macrophages remodeling EMT and predicting survival in colorectal carcinoma

ABSTRACT The immune contexture, a composition of the tumor microenvironment, plays multiple important roles in cancer stem cell (CSC) and epithelial–mesenchymal transition (EMT), and hence critically influences tumor initiation, progression and patient outcome. Tumor-associated macrophages (TAMs) are abundant in immune contexture, however their roles in CSC, EMT and prognosis of colorectal cancer (CRC) have not been elucidated. In 419 colorectal carcinomas, immune cell types (CD68+ macrophages, CD3+, CD4+ or CD8+ T lymphocytes, CD20+ B lymphocytes), EMT markers (E-cadherin and Snail) as well as the stem cell marker (CD44v6) were detected in tumor center (TC) and tumor invasive front (TF) respectively by immunohistochemistry. Tumor buds, that represent EMT phenotype, were also counted. It was found CD68+ macrophages were the most infiltrating immune cells in CRC. By correlation analysis, more CD68+ TF macrophages were associated with more CD44v6 expression (p < 0.001), lower SnailTF expression (p = 0.08) and fewer tumor buds (p < 0.001). More CD68+ TF macrophages were significantly related to more CD3+ TF T lymphocytes (p = 0.002), CD8+ TF T lymphocytes (p < 0.001) and CD20+ TF B lymphocytes counts (p = 0.004). Strong CD68+ TF macrophages infiltration also predicted long term overall survival. CRC patients with more tumor buds had worse survival. However, strong CD68+ TF macrophages infiltration could reverse the unfavorable results since patients with more tumor buds but increasing CD68+ TF macrophages infiltration had the favorable outcome, similar to lower tumor buds groups. This study provided direct morphological evidence that tumor-associated macrophages in the invasive front play critical roles in fighting with the unfavorable results of tumor buds, thus resulting favorable outcomes for CRC patients.
Semantic sentence similarity incorporating linguistic concepts

A natural language allows a set of simpler ideas to be combined together to communicate much more complex ideas. This ability gives language the potential for use as a highly intuitive method of human interaction. However, this freedom of expression makes interpreting language with automation extremely challenging. Semantic sentence similarity is an approach which allows the knowledge of how to compare simpler units, such as words, to obtain a measure of similarity between two sentences. This similarity can allow existing knowledge to be applied to new situations. The objective of this research is to show that a sentence similarity model can be improved through the inclusion of Linguistic concepts, with the aim of producing a more accurate model. This presents the challenge of adapting the human focused rules of Linguistics for sentence similarity and how to evaluate individual component effects in isolation. This research successfully overcame these barriers through the development of an extensible modular framework and construction of a new mathematical model for this framework , called SARUMAN. The core contribution of the research resulted from gradually incorporating fundamental Linguistic components to SARUMAN including: disambiguation by part of speech; treating the sentence as clauses, and advanced word interaction to handle where meanings merge. The most advanced being called SCAWIT. From experiments on a small data set, each of these introduced concepts showed statistically significant improvement in the Pearson's correlation (0.05 or more) over the previous version. The produced models were capable of processing several hundred sentence pairs a second with a single processor. A further significant advance to the field of sentence similarity was the introduction of opposites to sentence similarity. This was conceptually beyond the pre-existing models and showed strong results for an extension of SCAWIT, called SANO. Other novel contribution was added through automated word sense disambiguation from WordNet definitions; and the use of a properties of words model. Some of these changes have potential but did not yield significant improvement with the current knowledge base.
28 GHz Switched-Beam Antenna Based on S-PIN Diodes for 5G Mobile Communications

This letter presents a 28 GHz switched five-beam antenna system based on a rectangular waveguide and a reconfigurable semiconductor circuit (RSC) with slots. Surface p-i-n diodes are used to close or open slots in order to achieve required configuration of an aperture. The RSC with a modified WR28 waveguide composes a reconfigurable radiating structure (RRS), which provides three beams directed toward 0°, 30°, and 45°. Beam switching is achieved by reconfigurable arrangement of a set of slots. Complementary RRSs connected to the electromechanical RF switch is used to generate remaining −30° and −45° beams. The gain of each generated beam is similar because different numbers of slots are opened, i.e., three, five, and nine slots for beams directed toward 0°, 30°, and 45°, respectively. Aperture of the antenna is controlled by a unit composed of high-current operational amplifiers. Measured results validate the performance of designed millimeter-wave reconfigurable antenna.
Proteomic profiling of antibody-inducing immunogens in tumor tissue identifies PSMA1, LAP3, ANXA3, and maspin as colon cancer markers

We hypothesized that cancer tissue immunogens – antigens capable of inducing specific antibody production in patients – are promising targets for development of precision diagnostics and humoral immunotherapies. We developed an innovative immuno-proteomic strategy and identified new immunogenic markers of colon cancer. Proteins from cancers and matched normal tissues were separated by 2D gel electrophoresis and blotted with serum antibodies from the same patients. Antibody-reactive proteins were sequenced by mass spectrometry and validated by Western blotting and immunohistochemistry. 170 serum antibody-reactive proteins were identified only in cancerous but not matched normal. Among these, proteasome subunit alpha type 1 (PSA1), leucine aminopeptidase 3 (LAP3), annexin A3 (ANXA3), and maspin (serpin B5) were reproducibly found in tissues from three patients. Differential expression patterns were confirmed in samples from eight patients with various stages of colon adenocarcinoma and liver metastases. These tumor-resident proteins and/or their associated serum antibodies may be promising markers for colon cancer screening and early diagnosis. Furthermore, tumor tissue-specific antibodies could potentially be exploited as immunotherapeutic targets against cancer. More generally, proteomic profiling of antibody-inducing cancer-associated immunogens represents a powerful generic method for uncovering the tumor antigen-ome, i.e., the totality of immunogenic tumor-associated proteins.
Chronic Calf Pain Caused by Fibroma‐Induced Chronic Inflammation Around the Tibial and Peroneal Nerves that Was Misdiagnosed as Centralized Neuropathic Pain: A Case Report

The etiology of calf pain varies widely; therefore, it is difficult to diagnose and requires careful history taking and physical examination by primary care unit physicians. Because ultrasonography is easy to perform, cheap, and readily available to physicians during a routine consultation, it is the first choice of modality for the evaluation of calf pain. However, simple inflammation around the nerve should also be considered as a possible etiology. Here we describe a 35‐year‐old man with chronic pain in the right calf that was actually caused by fibroma‐induced chronic inflammation around the tibial and peroneal nerves but misdiagnosed as centralized neuropathic pain.
Emerging Importance of Phytochemicals in Regulation of Stem Cells Fate via Signaling Pathways

To reach ideal therapeutic potential of stem cells for regenerative medicine purposes, it is essential to retain their self‐renewal and differentiation capacities. Currently, biological factors are extensively used for stemness maintaining and differentiation induction of stem cells. However, low stability, high cost, complicated production process, and risks associated with viral/endotoxin infection hamper the widespread use of biological factors in the stem cell biology. Moreover, regarding the modulation of several signaling cascades, which lead to a distinct fate, phytochemicals are preferable in the stem cells biology because of their efficiency. Considering the issues related to the application of biological factors and potential advantages of phytochemicals in stem cell engineering, there is a considerable increasing trend in studies associated with the application of novel alternative molecules in the stem cell biology. In support of this statement, we aimed to highlight the various effects of phytochemicals on signaling cascades involved in commitment of stem cells. Hence, in this review, the current trends in the phytochemicals‐based modulation of stem cell fate have been addressed. Copyright © 2017 John Wiley & Sons, Ltd.
In vitro Effects of Leptin on Human Adipocyte Metabolism

Objective: Leptin receptors are expressed in adipocytes, suggesting potential autocrine/paracrine effects. Studies on the direct effects of leptin on adipose tissue metabolism in different species have yielded controversial data. To assess the in vitro effects of leptin on human adipocyte metabolism: lipolysis, the insulin-induced inhibition of lipolysis and lipogenesis were studied in adipocytes obtained from infants and adults. Methods: Lipolysis was studied by incubating adipocytes with increasing concentrations of leptin or isoprenaline. Glycerol in the incubation medium was measured as an indicator of lipolysis. For the lipogenesis and insulin-induced inhibition of lipolysis experiments, the cells were preincubated with 0, 25, or 250 ng/ml of leptin for 2 h. Results: Leptin did not stimulate lipolysis in human adipocytes, either in children or adults. Preincubation with leptin did not affect the insulin-induced inhibition of lipolysis, but decreased the insulin-induced lipogenesis (p < 0.05). Conclusions: This study shows that leptin has no direct lipolytic effect in human adipocytes. The lack of effect on the insulin-induced inhibition of lipolysis and the negative effect on lipogenesis indicates that the effect of leptin is not at the proximal insulin-signalling pathway but further downstream.
The Endocrine and Metabolic Characteristics of a Large Bardet-Biedl Syndrome Clinic Population

Context Bardet-Biedl syndrome (BBS) is a rare autosomal recessive disorder in which previous reports have described obesity and a metabolic syndrome. Objective We describe the endocrine and metabolic characteristics of a large BBS population compared with matched control subjects. Design We performed a case-control study. Setting This study was performed at a hospital clinic. Patients Study patients had a clinical or genetic diagnosis of BBS. Main Outcome Measurements Our study determined the prevalence of a metabolic syndrome in our cohort. Results A total of 152 subjects were studied. Eighty-four (55.3%) were male. Mean (± standard deviation) age was 33.2 ± 1.0 years. Compared with age-, sex-, and body mass index-matched control subjects, fasting glucose and insulin levels were significantly higher in subjects with BBS (glucose: BBS, 5.2 ± 1.2 mmol/L vs control, 4.9 ± 0.9 mmol/L, P = 0.04; insulin: BBS, 24.2 ± 17.0 pmol/L vs control, 14.2 ± 14.8 pmol/L, P < 0.001). Serum triglycerides were significantly higher in subjects with BBS (2.0 ± 1.2 mmol/L) compared with control subjects (1.3 ± 0.8 mmol/L; P < 0.001), but total cholesterol, high-density lipoprotein, and low-density lipoprotein were similar in both groups. Systolic blood pressure was higher in the BBS group (BBS, 135 ± 18 mm Hg vs control subjects, 129 ± 16 mm Hg; P = 0.02). Alanine transaminase was raised in 34 (26.8%) subjects with BBS, compared with five (8.9%) control subjects (P = 0.01). The rate of metabolic syndrome, determined using International Diabetes Federation criteria, was significantly higher in the BBS group (54.3%) compared with control subjects (26% P < 0.001). Twenty-six (19.5%) of male subjects with BBS were hypogonadal (serum testosterone, 9.9 ± 5.3 mmol/L), but significant pituitary abnormalities were uncommon. Subclinical hypothyroidism was present in 24 of 125 (19.4%) patients with BBS, compared with 3 of 65 (4.6%) control subjects (P = 0.01). Conclusions Insulin resistance and the metabolic syndrome are increased in adult patients with BBS compared with matched control subjects. Increased subclinical hypothyroidism in the BBS cohort needs further investigation.
Effects of Perinatal Exposure to Phthalates and a High-Fat Diet on Maternal Behavior and Pup Development and Social Play

Humans are ubiquitously exposed to many phthalates, a class of endocrine-disrupting chemicals commonly used in many consumer goods, and diet, especially fatty food, is presumed to be a major source of exposure. Here, we use a rat model of human prenatal exposure to investigate the potential interactive effects of an environmentally relevant mixture of phthalates and a maternal high-fat diet (HFD). From gestation through postnatal day (P)10, dams consumed the mixture of phthalates (0, 200, or 1000 μg/kg/d) and were fed a control diet or HFD. In males, perinatal exposure to the mixture of phthalates decreased prepubertal body weight and, in a dose-specific manner, periadolescent social play behavior. A dose-specific effect from phthalates with HFD was also seen in increased time alone in females during social play. HFD resulted in dams consuming more calories, having greater gestational weight gain, and licking and nursing their pups more, such that an early postnatal HFD generally increased pup body weight. There also was a tendency for increased oxidative stress markers at P10 within the medial prefrontal cortex of males exposed to the relatively high dose of phthalates and HFD. Effects on gene expression were inconsistent at P10 and P90 in both the medial prefrontal cortex and hypothalamus. Overall, this study demonstrates that phthalates and a maternal HFD only rarely interacted, except in oxidative stress markers in males. Additionally, perinatal exposure to an environmentally relevant mixture of phthalates can have a modest, but lasting, impact on social behaviors in both males and females.
Estrogen, Progesterone, and Pregnancy Termination Alter Neural Activity in Brain Regions That Control Maternal Behavior in Rats

Estrogen stimulates maternal behavior in rats, but does so most potently when its administration is temporally coupled with the termination of pregnancy. In contrast, this effect of estrogen is blocked when subjects are administered a large dose of progesterone concurrent with estrogen. The current study was performed to examine the neural circuitry influenced by these treatments and pup presentation during the hormonally-mediated onset and inhibition of maternal behavior. In experiment I, estrogen induced c-Fos immunoreactivity (Fos-IR) in the medial preoptic area (MPOA) in virgin rats, but was much more effective when administered to pregnancy-terminated rats, suggesting that pregnancy termination increases MPOA’s susceptibility to the physiological effects of estrogen. In experiment II, administering progesterone concurrently with estrogen in pregnancy-terminated rats strongly inhibited estrogen-stimulated Fos-IR in the MPOA, indicating that the physiological effects of estrogen on the MPOA are blocked if high progesterone levels are maintained. In experiment III, pregnancy-terminated subjects were administered estrogen, progesterone, or both hormones and presented with pups for 2 h. Approximately half of the subjects administered estrogen alone showed maternal behavior, but subjects receiving the other treatments were not maternal. In the MPOA, ventral bed nucleus of the stria terminalis (BSTv), and dorsal and intermediate lateral septum (LSd,i), maternal subjects showed the highest levels of Fos-IR, whereas subjects treated with progesterone alone or progesterone in combination with estrogen showed low levels of Fos-IR. These experiments suggest that estrogen could promote maternal behavior by enhancing pup-stimulated activity in the MPOA, BSTv, and LSd,i, regions believed to constitute the neural circuit that promotes maternal behavior, whereas progesterone could inhibit maternal behavior by inhibiting neural activity in some of these regions.
Thromboembolic complications following aminocaproic acid use in patients with hematologic malignancies

Abstract Aminocaproic acid is frequently used in patients with hematologic malignancy that present with thrombocytopenia with or without hemorrhage. We conducted a retrospective study to evaluate the safety of aminocaproic acid in 109 patients with hematologic malignancies. Patients were included if aminocaproic acid had been administered for at least 24 hours for the prevention or treatment of thrombocytopenic hemorrhage. Our primary outcome was thromboembolic complications defined as arterial or venous thrombotic events objectively confirmed by imaging studies. Thromboembolic complications occurred in five patients (4.6%) and all were venous thromboses. Other than the underlying malignancy, these patients also had many concurrent risk factors including indwelling central venous catheters, which could have contributed to thromboses. In conclusion, in our population of patients with a variety of hematological malignancies, aminocaproic acid does not appear to be associated with a high incidence of thromboembolic complications.
Distress Tolerance Links Sleep Problems with Stress and Health in Homeless.

OBJECTIVE We examined associations between sleep problems, distress intolerance, and perceived stress and health in a convenience sample of homeless adults. METHODS Participants (N = 513, 36% women, Mage = 44.5 ±11.9) self-reported sleep adequacy, sleep duration, unintentional sleep during the daytime, distress tolerance, urban stress, and days of poor mental health and days of poor physical health over the last month. The indirect effects of sleep problems on stress and health through distress tolerance were examined using a non-parametric, bias-corrected bootstrapping procedure. RESULTS Sleep problems were prevalent (eg, 13.0 ±11.4 days of inadequate sleep and 4.7 ±7.9 days of unintentionally falling asleep during the preceding month). Distress intolerance partially accounted for the associations of inadequate sleep and unintentionally falling asleep, but not sleep duration, with urban stress and more days of poor mental and physical health. CONCLUSIONS Many homeless individuals endure sleep problems. Given the connections between sleep and morbidity and mortality, results further support the need for more attention directed toward facilitating improvements in sleep quality to improve the quality of life of homeless adults, potentially including attention to improving distress tolerance skills.