Miracle-dz/UniFAR-FTUs huggingface dataset:
Investigating the operation of the affect heuristic: is it an associative construct?

Affect is of central importance in risk perception and risky decision-making, and the affect heuristic is a very influential construct developed in relation to this. We examined whether this heuristic operates at an associative level of processing as, despite much theorising, empirical evidence on this issue is lacking. We compared affective heuristic task performance with performance on established implicit association tasks. Participants (n = 151) completed explicit attitude and risk measures, and five experimental tasks (three Go/No-Go Association Tasks (GNAT), a priming task and a time-pressured affect heuristic task). A modified ‘risk-benefit’ GNAT provided a speeded analogue of the affect heuristic task which was equivalent to the evaluative GNAT in terms of response mode and cognitive effort. Affect heuristic task performance was not associated with implicit task performance. The evaluative GNAT did not correlate with the risk-benefit GNAT (speeded affect heuristic task). However, affect heuristic task performance was strongly associated with, and significantly predicted by, explicit affective attitude and explicit risk measures suggesting that this heuristic may primarily reflect deliberative rather than associative processing. Findings contradict the (much cited) notion that this important psychological construct operates at an associative level. However, the conclusions that can be drawn from this study are limited by the implicit attitude measures used here. In future research, it would be desirable to use different measures of implicit associations, e.g. the Single-Category Implicit Association task, to further interrogate the processes operating within the affect heuristic.
Hypercapnic Acidosis Preserves Gastric Mucosal Microvascular Oxygen Saturation in a Canine Model of Hemorrhage

The authors aimed to clarify the effects of hypercapnic acidosis and its timing on gastric mucosal oxygenation in a canine model of hemorrhage. This was designed as a prospective, controlled, randomized animal study set in a university research laboratory. Five chronically instrumented dogs were used. Dogs were repeatedly anesthetized (sevoflurane 1.5 MAC), mechanically ventilated, and randomized to each of the following protocols. In a control series (CON), animals underwent hemorrhage during normoventilation (etCO2, 35 mmHg). In a second series, hypercapnia (etCO2, 70 mmHg) was applied before onset of hemorrhage (prophylactic hypercapnia), whereas in the third series, hypercapnia was applied after hemorrhage (therapeutic hypercapnia, THE). Microvascular oxygenation (&mgr;HbO2) of the gastric mucosa was continuously assessed by tissue reflectance spectrophotometry. Cardiac output was continuously measured, and oxygen delivery (DO2) was intermittently calculated. In CON, hemorrhage decreased DO2 (from 11 ± 3 mL·kg−1·min−1 to 8 ± 2 mL·kg−1·min−1 and 8 ± 2 mL·kg−1·min−1 after 30 and 75 min, respectively) and &mgr;HbO2 (from 57% ± 4% to 43% ± 11% and 50% ± 11%). Prophylactic hypercapnia attenuated the effects of hemorrhage on DO2 (12 ± 2 mL·kg−1·min−1 to 10 ± 2 mL·kg−1·min−1 and 11 ± 2 mL·kg−1·min−1) and preserved &mgr;HbO2 (52% ± 3% to 47% ± 5% and 57% ± 3%). Initial effects of hemorrhage in THE were comparable to CON (DO2 from 11 ± 2 mL·kg−1·min−1 to 8 ± 1 mL·kg−1·min−1; &mgr;HbO2 from 56% ± 7% to 43% ± 9%), but after application of hypercapnic acidosis, baseline levels were restored (DO2 10 ± 3 mL·kg−1·min−1; &mgr;HbO2 52% ± 14%). Hypercapnic acidosis applied before or after hemorrhage (THE) preserves microvascular mucosal oxygenation. If these experimental findings may be transferred to the clinical setting, deliberate hypercapnic acidosis could serve to augment oxygenation of the splanchnic region in states of compromised circulation, e.g., hemorrhage.
Evaluating the Applicability of a Biodegradable Osteosynthesis Plating System in the Management of Zygomatico-Maxillary Complex Fractures

Objective. The present study was undertaken to evaluate and analyze the efficacy of bioresorbable plates and screws in internal fixation of zygomatico-maxillary complex (ZMC) fractures and to evaluate the incidence of complications associated with the procedure. Study Design. Case series with planned data collection. Setting. Pt BD Sharma University of Health Sciences. Subject and Methods. A total of 14 patients with isolated ZMC fractures were included, and exclusion of grossly comminuted, pathological, and infected fractures was done. Open reduction internal fixation was done with biodegradable plates and screws. All patients were reviewed clinically and radiographically at regular follow-up. Occlusion, stability of fracture segments, anesthesia or paresthesia of the infraorbital nerve region, and various complications were assessed periodically. Results. Fourteen patients with 34 fracture sites were included in the study. Intraoperatively, there were 2 incidences of screw head fracture. As observed clinically, there was complete stability of fracture segments, and no maxillomandibular fixation was required postoperatively. Paresthesia of the infraorbital nerve was present in 5 patients, but the sensation recovered completely in the first 3 months after surgery. The mean pain score was 3 on a visual analogue scale. In 1 case, ectropion developed, and dehiscence occurred in another patient in the early postoperative period. Postoperative radiographs were evaluated for the accuracy of fracture reduction and stability of fixation. Conclusion. The biodegradable osteosynthesis system exhibits adequate strength and has negligible complications. This system is technique sensitive with satisfactory results in the management of mild to moderately displaced ZMC fractures.
Immunotherapeutic efficacy of bovine colostral immunoglobulins from a hyperimmunized cow against cryptosporidiosis in neonatal mice

Infection with Cryptosporidium parvum, a ubiquitous protozoan parasite of virtually all mammals, can cause mild to severe diarrhea in immunocompetent hosts and life-threatening diarrhea in immunocompromised hosts. Passive immunotherapy of experimentally infected animals and naturally infected humans with hyperimmune bovine colostrum has been reported to be efficacious, whereas chemotherapy has not. In this study, the efficacy of specific immunoglobulin isotypes purified from bovine colostrum from a cow hyperimmunized with Cryptosporidium parvum was assessed in neonatal BALB/c mice. Mice were orally infected with oocysts and treated with whole whey immunoglobulin G1 (IgG1), IgG2, IgA, or IgM at six intervals from 22 to 66 h postinfection. In histologic sections of intestine examined at 72 h postinfection, the reduction in number of intestinal stages in treated mice versus untreated controls was very highly significant (P less than 0.0001). The greatest reduction in parasite number was found in mice treated with IgG1, IgA, or whey.
Intraocular Pressure Variations during Zygomatic Fracture Reduction and Fixation: A Clinical Study

Background: The reduction of midface fractures has been associated with the rare but devastating complication of blindness. An increase in intraocular pressure is important in the mechanism of blindness in this setting. In this study, the authors assessed the intraocular pressure in patients who underwent zygomatic fracture reduction (with or without fixation). Methods: Using applanation tonometry, 29 patients underwent intraocular pressure measurements before, during, and after fracture fixation. The contralateral pressures were measured and used as the control. Results: There were 29 patients with a mean age of 35 years, and the mean time to surgery was 5 days. Preoperatively, all patients had normal intraocular pressures and normal visual acuity. All patients underwent a Gillies lift and 18 patients required open reduction and fixation of the frontozygomatic suture (n = 4) or the infraorbital margin (n = 2), and the remainder (n = 12) required fixation of both points. There was no statistically significant increase in the intraocular pressures following the reduction of uncomplicated zygomatic fractures. Statistically significant pressure reductions were noted immediately after reduction and fixation. Conclusions: The surgical reduction of uncomplicated zygomatic fractures has no adverse effect on the intraocular pressure. It is the authors' opinion that adjunctive measures to reduce the pressures are unnecessary.
Localization of Cell Division Protein FtsQ by Immunofluorescence Microscopy in Dividing and Nondividing Cells ofEscherichia coli

ABSTRACT The localization of cell division protein FtsQ in Escherichia coli wild-type cells was studied by immunofluorescence microscopy with specific monoclonal antibodies. FtsQ could be localized to the division site in constricting cells. FtsQ could also localize to the division site in ftsQ1(Ts) cells grown at the permissive temperature. A hybrid protein in which the cytoplasmic domain and the transmembrane domain were derived from the γ form of penicillin-binding protein 1B and the periplasmic domain was derived from FtsQ was also able to localize to the division site. This result indicates that the periplasmic domain of FtsQ determines the localization of FtsQ, as has also been concluded by others for the periplasmic domain of FtsN. Noncentral FtsQ foci were found in the area of the cell where the nucleoid resides and were therefore assumed to represent sites where the FtsQ protein is synthesized and simultaneously inserted into the cytoplasmic membrane.
Formulation and Evaluation of Floating Drug Delivery Systems of Propranolol HCl using Modified Pulsincap Technique

Oral controlled release drug delivery systems are one of the promising systems for prolonged duration of action for chronic diseases like hypertension, diabetes etc. Drugs with absorption window in upper GIT (gastro intestinal tract) require special attention for effective therapy. Gastric floating drug delivery systems (GFDDS) are one such suitable delivery system. In our present investigation we attempted to utilize modified pulsincap technique to develop GFDDS of propranolol HCl using PEO WSR 303 polymer. Modified pulsincap technique involve exposing the capsule body to formaldehyde vapors which results in hardening of the shell. The drug- polymer- excipient mixture was filled into the hardened body and covered with untreated cap. All the formulations were evaluated for residual formaldehyde estimation, weight variation, drug content, in-vitro buoyancy, drug release pattern, compatibility studies etc. The formulations F1-4 with drug-polymer ratio 1:0.75 of 1 hr formaldehyde vapour exposure and F2-3 with drug: polymer ratio 1:0.5 of 2 hrs formaldehyde vapour exposure were considered as the optimized formulations as they released 99.99% and 100.00% of the drug in 12 hrs respectively with sufficient buoyancy characteristics. Promising results concluded that the modified pulsincap technique can be successfully used for the development of GFDDS of propranolol HCl using PEO WSR 303.
Effect of Impact Location upon Sub-Impacts between Beam and Block

The present investigation is concerned with sub-impacts taken placed when a rigid hemispherical-head block transversely impacts against a beam at different locations. Dynamic substructure technique for elastic-plastic impact is applied to solve numerically this problem. The time history of impact force and energy exchange between block and beam are obtained. The process of sub-impacts is analyzed from the energy exchange point of view. The results verify the influences of the impact location on impact duration, the first sub-impact and energy exchange between the beam and the block. Keywords—Beam, sub-impact, substructure, elastic-plasticity.
CYP3A4-Transfected Caco-2 Cells as a Tool for Understanding Biochemical Absorption Barriers: Studies with Sirolimus and Midazolam

CYP3A4-transfected Caco-2 cells were used as an in vitro system to predict the importance of drug metabolism and transport on overall drug absorption. We examined the transport and metabolism of two drugs; midazolam, an anesthetic agent and CYP3A4 substrate, and sirolimus, an immunosuppressant and a dual CYP3A4/P-glycoprotein (P-gp) substrate, in the presence of cyclosporine (CsA, a CYP3A4/P-gp inhibitor) or N-{4-[2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)-ethyl]-phenyl}-9,10-dihydro-5-methoxy-9-oxo-4-acridine carboxamine (GG918) (an inhibitor of P-gp and not CYP3A4). All major CYP3A4 metabolites were formed in the cells (1-OH > 4-OH midazolam and 39-O-desmethyl > 12-OH > 11-OH sirolimus), consistent with results from human liver microsomes. There was no bidirectional transport of midazolam across CYP3A4-transfected Caco-2 cells, whereas there was a 2.5-fold net efflux of sirolimus (1 μM) that disappeared in the presence of CsA or GG918. No change in the absorption rate or extraction ratio (ER) for midazolam was observed when P-gp was inhibited with GG918. Addition of GG918 had a modest impact on the absorption rate and ER for sirolimus (increased 58% and decreased 25%, respectively), whereas a 6.1-fold increase in the absorption rate and a 75% decrease in the ER were found when sirolimus was combined with CsA. Although both midazolam and sirolimus metabolites were preferentially excreted to the apical compartment, only sirolimus metabolites were transported by P-gp as determined from inhibition studies with GG918. Using CYP3A4-transfected Caco-2 cells we determined that, in contrast to P-gp, CYP3A4 is the major factor limiting sirolimus absorption. The integration of CYP3A4 and P-gp into a combined in vitro system was critical to unveil the relative importance of each biochemical barrier.
OriginalClinicalScienceçGeneral Cytokine Release After Treatment With Rituximab in Renal Transplant Recipients

Background. Treatment with rituximab may be accompanied by a systemic cytokine release. We studied the effects of a single dose of rituximab on cytokine levels in transplant patients and examined the underlying mechanism.Methods. Twenty renal transplant recipients (10 rituximab-treated, 10 placebo-treated) were recruited from a randomized clinical trial. Rituximab or placebo was infused during surgery, and blood samples were taken before, during, and after surgery and analyzed for interleukin (IL)-2, IL-4, IL-6, IL-10, IL-12, IL-17, interferon-γ, macrophage inflammatory protein (MIP)-1β, transforming growth factor-β, and tumor necrosis factor-α. in vitro, healthy donor peripheral blood mononuclear cells, purified B cells, monocytes, natural killer (NK) cells, or combinations thereof were incubated with rituximab, rituximab-F(ab′)2, or medium and MIP-1β, IL-10, interferon-γ, and tumor necrosis factor-α levels were measured in the supernatant. Results. Rituximab-treated patients had higher serum levels of IL-10 (101 ± 35 pg/mL vs 41 ± 9 pg/mL; P < 0.01) and MIP-1β (950 ± 418 pg/mL vs 125 ± 32 pg/mL; P < 0.001) compared to placebo-treated patients at 2 hours after start of infusion. There was no difference in the level of other cytokines. In vitro, the addition of rituximab, but not rituximab-F(ab′)2 fragments, only led to significantly increased levels of MIP-1β in co-cultures of B and NK cells. Levels of MIP-1β were higher in patients with a high affinity Fc-receptor compared to those with a lower affinity FcγRIIIa (1356 ± 184 pg/mL vs 679 ± 273 pg/mL; P < 0.01). Conclusions. In addition to B-cell depletion, rituximab can modulate the immune response by inducing cytokine secretion, especially IL-10 and MIP-1β. Rituximab-induced MIP-1β secretion depends on the combined presence of B cells and FcR-bearing cells, especially NK cells.
Proto-oncogene FBI-1 (Pokemon) and SREBP-1 Synergistically Activate Transcription of Fatty-acid Synthase Gene (FASN)*

FBI-1 (Pokemon/ZBTB7A) is a proto-oncogenic transcription factor of the BTB/POZ (bric-à-brac, tramtrack, and broad complex and pox virus zinc finger) domain family. Recent evidence suggested that FBI-1 might be involved in adipogenic gene expression. Coincidentally, expression of FBI-1 and fatty-acid synthase (FASN) genes are often increased in cancer and immortalized cells. Both FBI-1 and FASN are important in cancer cell proliferation. SREBP-1 is a major regulator of many adipogenic genes, and FBI-1 and SREBP-1 (sterol-responsive element (SRE)-binding protein 1) interact with each other directly via their DNA binding domains. FBI-1 enhanced the transcriptional activation of SREBP-1 on responsive promoters, pGL2-6x(SRE)-Luc and FASN gene. FBI-1 and SREBP-1 synergistically activate transcription of the FASN gene by acting on the proximal GC-box and SRE/E-box. FBI-1, Sp1, and SREBP-1 can bind to all three SRE, GC-box, and SRE/E-box. Binding competition among the three transcription factors on the GC-box and SRE/E-box appears important in the transcription regulation. FBI-1 is apparently changing the binding pattern of Sp1 and SREBP-1 on the two elements in the presence of induced SREBP-1 and drives more Sp1 binding to the proximal promoter with less of an effect on SREBP-1 binding. The changes induced by FBI-1 appear critical in the synergistic transcription activation. The molecular mechanism revealed provides insight into how proto-oncogene FBI-1 may attack the cellular regulatory mechanism of FASN gene expression to provide more phospholipid membrane components needed for rapid cancer cell proliferation.
Social capital and adherence to cervical and breast cancer screening guidelines: a cross-sectional study in rural Crete.

Breast and cervical cancers are among the leading causes of female mortality. The reasons that make women adhere, or not, to screening guidelines are not only related to individual and health characteristics but are also placed in a wider social and cultural context. Social capital might facilitate the dissemination of relevant knowledge of and the adherence to cancer screening guidelines. This cross-sectional study explored the associations of individual-level social capital with breast and cervical cancer screening and the knowledge for the existence of relevant screening tests (Pap test and mammography) in the municipality of Gorgolaini, a rural area in Crete, Greece. A random sample of 131 of the 592 women of the 2001 electoral register were invited to participate in the study and 125 completed the Social Capital Questionnaire and two questions on self-reported health knowledge and behaviour (participation rate 95.4%). Women were eligible to participate if they were aged 35-75, had lived in the area for the last 10 years and were of Greek origin. Multiple logistic regressions were performed to establish associations among each social capital factor (total, participation in the community, value of life, tolerance for diversity, feelings of safety, family/friends connections) and knowledge of and adherence to breast and cervical cancer screening guidelines after adjustment for confounders. Our results suggest that early detection of breast and cervical cancers may be facilitated when taking into account the social context of the population.
THE MEASUREMENT OF FREE AND N‐ACETYLATED ASPARTIC ACIDS IN THE NERVOUS SYSTEM *

THE existence of high concentrations of N-acetylaspartic acid in the central nervous systems of mammals and birds has been known for a number of years (TALLEN, MOORE and STEIN, 1956) but its purpose there remains an enigma. It was felt that means for a rapid quantitative assay of this compound not only in extracts from whole brain but in histologically distinct layers of brain would be a valuable step towards elucidation of its function.
Endurance Training and its Effect upon the Activity of the GH-IGFs System in the Elderly

There is an age-associated decline in the activity of the GH-IGFs system. However, so far, it has not been studied, whether this decline in somatotrophic activity might be preventable by intensive exercising. We studied 11 elderly male (50-78 years) marathon runners and 10 age-matched male (52-73 years) sedentary controls to evaluate plasma concentrations of GH, total and free IGF-I and IGF-II and of IGF-binding protein-1 (IGFBP-1), IGFBP-2, IGFBP-3 and insulin. When comparing the two groups (runners vs controls) no differences were found in GH (1.0 +/- 1.2 vs 1.3 +/- 1.3 microg/l [mean +/- SD]), IGF-1 (115 +/- 23 vs 113 +/- 21 microg/l), IGF-II (961 +/- 192 vs 864 +/- 125 microg/l), free IGF-1 (227 +/- 80 vs 318 +/- 146 ng/l), free IGF-II (563 +/- 249 vs 492 +/- 108 ng/l), IGFBP-3 (2403 +/- 515 vs 2307 +/- 326 microg/l) or insulin (26 +/- 13 vs 27 +/- 18 mU/l). However, IGFBP-1 (4.44 +/- 2.61 vs 2.28 +/- 0.93 microg/l) and IGFBP-2 (493 +/- 143 vs 340 +/- 186 microg/l) were found to be significantly increased in marathon runners. In conclusion, our findings do not support the hypothesis that the age-associated decline in GH, IGF-1 and IGFBP-3 may be preventable by intensive endurance training. However, marathon running affects the regulation of the GH-IGFs system activity at the level of IGFBP-1 and -BP-2.
Internet Financial Reporting in UAE- Analysis and Implications

The paper is an empirical study which investigates the extent of Internet Financial Reporting (IFR) among United Arab Emirates (UAE) companies listed on the Abu Dhabi Securities Exchange (ADX). The population of the study consists of all the 65 companies listed on the first market of ADX, divided into ten (10) sectors based on ADX classification. The study also expands its scope to investigate the significant determinants of IFR in the companies studied. The findings show that 89% of the listed companies have websites while 11% do not have websites. Also, 60% of the ADX-listed companies having websites revealed financial information online whereas the remaining 40% did not disclose financial information on their websites. Logistic regression has been employed as the method of estimation on the cross sectional data collected as on 31 st December, 2010. The researchers examine the effect of eight (8) selected characteristics on companies that report financial information on their websites. These characteristics are size, profitability, liquidity, financial leverage, ownership concentration, type of ownership, corporate governance and company age. Results reveal that profitability and corporate governance act as significant determinants of IFR in the sample studied.
Rhythmic Activity and the Discrimination of Stimuli in Time

Two experiments were conducted to test the effect of changes in motoric activity on the thresholds for CFF and apparent motion. The main findings were that an increase (decrease) in motoric activity above (below) the preferred rate delays (fosters) the perception of fusion and simultaneity. These findings were interpreted as giving evidence for the notion that organismic rhythms are critical in the temporal organization of perceptual events.