Miracle-dz/UniFAR-FTUs huggingface dataset:
Commensal microbiome effects on mucosal immune system development in the ruminant gastrointestinal tract

Abstract Commensal microflora play many roles within the mammalian gastrointestinal tract (GIT) that benefit host physiology by way of direct or indirect interactions with mucosal surfaces. Commensal flora comprises members across all microbial phyla, although predominantly bacterial, with population dynamics varying with host species, genotype, and environmental factors. Little is known, however, about the complex mechanisms regulating host–commensal interactions that underlie this mutually beneficial relationship and how alterations in the microbiome may influence host development and susceptibility to infection. Research into the gut microbiome has intensified as it becomes increasingly evident that symbiont–host interactions have a significant impact on mucosal immunity and health. Furthermore, evidence that microbial populations vary significantly throughout the GIT suggest that regional differences in the microbiome may also influence immune function within distinct compartments of the GIT. Postpartum colonization of the GIT has been shown to have a direct effect on mucosal immune system development, but information is limited regarding regional effects of the microbiome on the development, activation, and maturation of the mucosal immune system. This review discusses factors influencing the colonization and establishment of the microbiome throughout the GIT of newborn calves and the evidence that regional differences in the microbiome influence mucosal immune system development and maturation. The implications of this complex interaction are also discussed in terms of possible effects on responses to enteric pathogens and vaccines.
Public opinion and trust in scientists: the role of the research context, and the perceived motivation of stem cell researchers

This research examined why the public may be less supportive of stem cell research when conducted in a private compared to public research context. A representative sample ( n = 403) of Australians who were exposed to information relating to privately funded scientists were significantly less likely to approve of stem cell research than those who were presented with a scenario of scientists working within a publicly funded University (n = 401) and a control condition (n = 404). Mediation analyses revealed that the decrease in approval was primarily associated with the tendency of privately funded scientists to be trusted less than their publicly funded counterparts. Public trust in University scientists was also found to be higher than that of private scientists because publicly funded scientists were perceived to be motivated more by benevolence, and more likely to produce benefits that will be accessible to the public. While private scientists were perceived to be more self interested than public scientists, perceived self interest did not explain the decrease in trust. There were also no significant differences across research contexts for the perceived competence of scientists or the likelihood that stem cell research would result in cures for diseases. The implications of these results are discussed in relation to the possible decrease in public trust that may occur alongside the increasing privatization of academic enquiry, and particularly controversial scientific research.
Deep Physiological Arousal Detection in a Driving Simulator Using Wearable Sensors

Driving is an activity that requires considerable alertness. Insufficient attention, imperfect perception, inadequate information processing, and sub-optimal arousal are possible causes of poor human performance. Understanding of these causes and the implementation of effective remedies is of key importance to increase traffic safety and improve driver's well-being. For this purpose, we used deep learning algorithms to detect arousal level, namely, under-aroused, normal and over-aroused for professional truck drivers in a simulated environment. The physiological signals are collected from 11 participants by wrist wearable devices. We presented a cost effective ground-truth generation scheme for arousal based on a subjective measure of sleepiness and score of stress stimuli. On this dataset, we evaluated a range of deep neural network models for representation learning as an alternative to handcrafted feature extraction. Our results show that a 7-layers convolutional neural network trained on raw physiological signals (such as heart rate, skin conductance and skin temperature) outperforms a baseline neural network and denoising autoencoder models with weighted F-score of 0.82 vs. 0.75 and Kappa of 0.64 vs. 0.53, respectively. The proposed convolutional model not only improves the overall results but also enhances the detection rate for every driver in the dataset as determined by leave-one-subject-out cross-validation.
Bright polar mesospheric clouds formed by main engine exhaust from the space shuttle's final launch

The space shuttle launched for the last time on 8 July 2011. As with most shuttle launches, the three main engines injected about 350 t of water vapor between 100 and 115 km off the east coast of the United States during its ascent to orbit. We follow the motion of this exhaust with a variety of satellite and ground-based data sets and find that (1) the shuttle water vapor plume spread out horizontally in all directions over a distance of 3000 to 4000 km in 18 h, (2) a portion of the plume reached northern Europe in 21 h to form polar mesospheric clouds (PMCs) that are brighter than over 99% of all PMCs observed in that region, and (3) the observed altitude dependence of the particle size is reversed with larger particles above smaller particles. We use a one- dimensional cloud formation model initialized with predictions of a plume diffusion model to simulate the unusually bright PMCs. We find that eddy mixing can move the plume water vapor down to the mesopause near 90 km where ice particles can form. If the eddy diffusion coefficient is 400 to 1000 m(2)/s, the predicted integrated cloud brightness is in agreement with both satellite and ground-based observations of the shuttle PMCs. The propellant mass of the shuttle is about 20% of that from all vehicles launched during the northern 2011 PMC season. We suggest that the brightest PMC population near 70 degrees N is formed by space traffic exhaust.
Fatty acid composition of the milk lipids of Nepalese women: correlation between fatty acid composition of serum phospholipids and melting point.

Milk was collected from 36 Nepalese women, 15 to 32 years of age, in order to investigate relationships between the proportions of intermediate chain-length (C10-C14) fatty acids and critical n-3 and n-6 polyunsaturated fatty acids in the milk lipids they were producing. Serum was also obtained from these lactating women and the fatty acid composition of their serum phospholipid fraction was determined and compared with that of the corresponding milk lipid fraction. Compared to women in technologically advanced parts of the world, the serum phospholipids of the Nepalese women contained nutritionally adequate proportions of linoleic acid (LA) (16.8%), alpha-linolenic acid (ALA) (0.53%), arachidonic acid (AA) (5.69%), and docosahexaenoic acid (DHA) (1.42%). However, although the milk lipids contained adequate proportions of ALA (1.81%), AA (0.43%), and DHA (0.23%), the lipids contained low to moderate percentages of LA (mean, 9.05%). Positive correlations were observed between the proportions of AA (P=0.001, r=0.50) and ALA (P=0.03, r=0.36) in the serum phospholipids and milk lipids of the women. As the proportion of C10-Cl4 fatty acids in the milk lipids increased from 10% to 40%, there was preferential retention of three critical n-3 and n-6 fatty acids (ALA, AA, and DHA) at the expense of two relatively abundant nonessential fatty acids, namely stearic acid and oleic acid. In addition, using fatty acid melting point data and the mol fraction of the 9 most abundant fatty acids in the milk, we estimated the mean melting point (MMP) of the milk lipids of the Nepalese women. The MMPs ranged from 29.3 to 40.5 degrees C (median, 35.5 degrees C). These results indicate that: 1) the levels of AA and ALA in the blood of lactating mothers influence the levels of these fatty acids in the milk they produce; 2) when the mammary gland produces a milk that is rich in C10-Cl4 fatty acids, it somehow regulates triglyceride synthesis in such a way as to ensure that the milk will provide the exclusively breast-fed infant with the amounts of the critical n-3 and n-6 fatty acids it requires for normal growth and development; and 3) the melting point of the milk lipid fraction is determined mainly by the mol % of the intermediate chain-length (C10-C14) fatty acids, oleic acid, linoleic acid, and alpha-linolenic acid.
Somatic Correlates of Adrenergic Activity during Aggression in the Lizard, Anolis carolinensis


Aggressive interactions in Anolis carolinensis result in increased circulating levels of epinephrine (Epi) and norepinephrine (NE) and conspicuous color changes. This activation of the adrenergic component of an acute stress response is externally represented by the darkening of the postorbital eyespot of A. carolinensis. In adult males, this site darkens in response to stressful physical stimulation (trauma, passive restraint) or psychological stimuli, most notably the sight of an aggressively intruding conspecific. Aggressive male A. carolinensis exhibit postorbital eyespot darkening; animals that have a longer latency to expression of this eyespot and those that never show this response were defeated in agonistic interactions. Also, during agonistic interactions, subjects that subsequently win are the first to display eyespot darkening. Plasma catecholamine levels are significantly elevated within 30 sec in both combatants. At 30 sec following the determination of the outcome, winning male lizards have plasma NE levels which are higher than those of losers. Castration, however, significantly increases the latency to eyespot darkening and extends its duration. Testosterone levels may therefore enhance the onset of Epi-mediated eyespot darkening as well as other aspects of the endocrine stress response. Elevated androgen levels and more rapid activation of acute catecholamine response increases the likelihood of becoming socially dominant.
Study of apparent hypersensitivity to Culicoides species in sheep in Israel

Between 1983 and 1997, a low incidence of seasonal allergic dermatitis was diagnosed in sheep in Israel aged eight months to eight years, in 10 flocks of a variety of breeds, but not the local Awassi breed. The 40 affected animals reacted with scratching, biting and vigorous stamping of the feet from April to November each year. The principal skin lesions were hyperkeratosis, spongiosis and infiltrations of eosinophils and mononuclear cells, typical of an allergic dermatitis which was probably a hypersensitivity reaction to biting insects. The epidemiological findings in relation to the area of Israel affected, the breeds of sheep and the distribution of the lesions suggested that the sheep's hypersensitivity was due to the bites of several species of Culicoides.
Distal Bypasses in Patients With Diabetes and Infrapopliteal Disease

The combination of diabetes and peripheral arterial disease (PAD) is challenging in many ways. The characteristic and complex distal distribution of PAD often encountered in patients with diabetes means that bypass surgery in this context is technically challenging. In addition, many of these patients have a burden of serious comorbidities that must be optimized and managed concurrently. While the authors acknowledge that “achieving success” in distal bypass relies on much more than technical expertise, there are some technical aspects that should be considered when planning surgery on these patients. This article outlines some important issues in the treatment pathway of a patient with diabetes and PAD requiring distal bypass surgery—from selection and optimization of the patient (in the context of a multidisciplinary team) and preoperative workup, to the operative strategy planning, technical tips, and nonoperative adjuncts. These considerations, as well as sound knowledge of the underlying disease process, confounding medical factors and awareness of the difficulty in predicting treatment outcomes, should help maximize the chances of success.
Parental Leave and Intra-Regime Differences in a Liberal Country: the Case of Four Canadian Provinces

This paper compares access to parental leave benefits in the four largest Canadian provinces –Québec, Ontario, Alberta and British Columbia between 2000 and 2016, using quantitative data from the Employment Insurance Coverage Survey. We show that inequalities in the receipt of benefits mirror and reinforce the structure of income and gender inequalities. We argue that Alberta and Québec represent two regimes of parental benefits. In Alberta the take-up of parental benefits is low, and is closely related to income and gender. Conversely, the vast majority of mothers and fathers have access to parental benefits in Québec. We argue that Alberta is closer to a liberal regime of parental benefits, while Québec is closer to a social-democratic model.
Examining the Factor Structure of Anxiety and Depression Symptom Items Among Adolescents in Santiago, Chile

The co-occurrence of emotional disorders among adolescents has received considerable empirical attention. This study aims to contribute to the understanding of co-occurring anxiety and depression by examining the factor structure of the Youth Self-Report used with a sample of low-income adolescents from Santiago, Chile. Data from two independent, randomly selected subsamples were analyzed using exploratory and confirmatory factor analyses. Results indicate the best fit for the data is a two-factor model of anxiety and depression symptoms, which factors anxiety and depression into separate latent constructs. Because the findings show that anxiety and depression are not measured by the same factor in this international sample, the results imply that a valid and useful distinction exists between these constructs. That these constructs are found to be separate factors suggests that anxiety and depression may have separate etiologies and consequences, which might be best addressed by separate intervention components. These findings are consistent with the viewpoint that anxiety and depression constructs have similar emotional features and, despite sharing a common underlying internalizing disorder, distinct items capture aspects of each construct.
Transition from organogenesis to stem cell maintenance in the mouse adrenal cortex

Mice showing mosaic expression of an appropriate marker gene that is activated during development provide simple tools for investigating cell lineages. We used the mosaic β-galactosidase staining patterns in adrenal cortices of 21OH/ LacZ transgenic mice to study both organogenesis and maintenance of the adult tissue. Randomly orientated mosaic patterns present in embryonic day 14.5 (E14.5) adrenals changed progressively during the perinatal period from discrete spots, via patches and radial arrays, to radial stripes, which first emerged between postnatal days 0 and 7 (P0 and P7). The mosaic radial stripe pattern was fully established by P21 and remained unchanged throughout the adult period (8–52 weeks). The mouse adrenal gland grew continuously between E14.5 and P21, including the period during which stripes emerge. Ki67-positive, proliferative cells in the adrenal cortex were mainly localized to the outer cell layers between E18.5 and P3. By P10, cell proliferation had increased, and the proliferative region had expanded but was still mainly confined to the outer cortex. Correlation of changes in mosaic patterns in 21OH/LacZ adrenal cortices with the locations of adrenocortical cell proliferation suggest that the radial stripes arise by edge-biased growth during the perinatal period, even if they are maintained by stem cells in adults. The stability of the adult stripe pattern suggests that stem cell function is unchanged between 8 and 52 weeks.
Liquidity in competitive dealer markets

We study a continuous‐time version of the intermediation model of Grossman and Miller. To wit, we solve for the competitive equilibrium prices at which liquidity takers' demands are absorbed by dealers with quadratic inventory costs, who can in turn gradually transfer these positions to an exogenous open market with finite liquidity. This endogenously leads to transient price impact in the dealer market. Smooth, diffusive, and discrete trades all incur finite but nontrivial liquidity costs, and can arise naturally from the liquidity takers' optimization.
Angle constraint biased PNG

In this paper, we propose a new biased proportional navigation guidance (BPNG) to get an arbitrary impact angle against stationary target. The closed form solution of this angle constraint BPNG (named ACBPNG) is derived. And with the solution, we can determine the exact bias for a required impact angle analytically. The solution is shown to be very useful to determine a proper homing guidance condition including initial engaging geometry and missile maneuverability. Because of its handy form to implement and easy solution to analyze, ACBPNG can be the most simple and effective scheme for homing guidance with impact angle constraint. ACBPNG could be applicable to either the system that uses seeker (both active and passive) or the system that does not use seeker.
Is Social Responsibility a Normal Good?

We investigate whether growth in consumer income causes an increased willingness to pay to mitigate negative externalities from consumption. Correlational field evidence suggests a positive relationship between income and social responsibility. To investigate a causal link, we conduct a laboratory market experiment in which firms and consumers can exchange products that differ in the degree to which they mitigate negative external impacts at the expense of higher production costs. Our treatments exogenously vary consumers’ incomes. Our experimental results reveal that growth in consumer income causes an increase in the share of socially responsible consumption in the laboratory. Such a causal relationship is significant from a policy perspective, as it implies that some negative external impacts of consumption activity can be mitigated as societies experience economic growth.
Human milk proteins may interfere in ELISA measurements of bovine β‐lactoglobulin in human milk

It is widely believed that cow's milk proteins ingested by the mother, in particular β‐lactoglobulin ([β‐LG), can pass into breast milk and thus sensitize predisposed infants. However, studies to evaluate bovine β‐LG in human milk have given conflicting results. The aim of this study was to analyse the correlation between the amount of cow's milk in the mother's diet and the presence of bovine β‐LG in breast milk. Human milk samples from 14 healthy non‐atopic women on diets with different cow's milk contents were examined. The total concentration of bovine β‐LG or β‐LG immuno‐like proteins (β‐LGIP) was determined by enzyme‐linked immunosorbent assay (ELISA). Two separation procedures utilizing ELISA plates and an affinity chromatography column were set up to identify the human whey components recognized by the anti‐β‐LG antibodies. β‐LGIP reactivities of milk from three groups on different diets were not significantly different. After splitting the antigen antibody complexes, three main protein components, human lactoferrin, human β‐casein and human α‐lactalbumin, were identified. This study would suggest that, at least in healthy subjects, false‐positive results in ELISA determinations of bovine β‐LG in human milk might be due to cross‐reactions between polyclonal antibodies and different protein antigens.
Ability grouping in secondary schools: effects on pupils' self-concepts.

BACKGROUND Current pressure on secondary schools to increase ability grouping has raised concerns about the impact of setting on pupils' self-concepts. Evidence from previous research is conflicting. A multidimensional measure and multilevel modelling promise to clarify the effects. AIMS This paper aims to examine the effects of structured ability grouping on year 9 pupils' self-concepts. SAMPLES The sample comprises over 3000 year 9 pupils (aged 13-14 years) in 45 mixed secondary comprehensive schools in England. The schools represent three levels of ability grouping in the lower school (years 7 to 9). METHODS Pupils responded to a multidimensional self-concept scale measuring academic and general facets of the self-concept. Measures of attainment were collected in English, mathematics and science. Multilevel modelling was used to examine the effect of the type of school on the general facets of the pupils' self-concept and the effects of setting in each curriculum subject on the academic facets of the self-concept. RESULTS Pupils' general self-concept was higher in the group of schools with moderate levels of setting. The degree of setting in mathematics and science had no effect on the corresponding academic self-concepts but setting in English tended to lower the self-concepts of the higher attaining pupils and raise the self-concepts of lower attaining pupils. Gender differences were consistent with previous research, with boys having significantly higher self-concept scores than girls, except in English. These findings indicate that the degree of stratification in schools can have an impact on adolescents' self-esteem and views of themselves in school.
Online focus group discussions: An attractive approach to data collection for qualitative health research

Data collection is a centerpiece in qualitative research. The use of multiple sources in data collection can improve conceptual interest of a qualitative inquiry and make it interesting. Online focus groups (OFGs) as a complementary choice to make the research project easier and engaging. Selection of the most appropriate method of data collection is essential for ensuring the trustworthiness. This commentary is noted to important issues involved in using OFG discussions for data collection in qualitative health research. In order to determine the suitability of data collection techniques, qualitative researchers are recommended for analysis the question, the research context, the preference of participants, technical issues, the advantages and disadvantages of each method, and provide authentic data to enrich their project by applying innovative approaches.
Immune privilege in sites of chronic infection: Leishmania and regulatory T cells

Summary: Leishmania are digenetic protozoan parasites that are inoculated into the skin by vector sand flies, are taken up by macrophages, and produce a spectrum of chronic diseases in their natural reservoir and susceptible human hosts. During the early establishment of infection in the skin and lymphoid organs, Leishmania produce multiple effects on macrophage and dendritic cell functions that inhibit their innate anti‐microbial defenses and impair their capacity to initiate T‐helper 1 cell immunity. In addition, the skin is a site preconditioned for early parasite survival by virtue of a high frequency of steady‐state, natural CD25+Foxp3+ regulatory T cells (Tregs) that function to suppress the generation of unneeded immune responses to infectious and non‐infectious antigens to which the skin is regularly exposed. In murine models of infection, antigen‐induced CD25+/−Foxp3−interleukin (IL)‐10+ Treg cells act during the effector phase of the immune response to control immunopathology and may also delay or prevent healing. Finally, following resolution of infection in healed mice, CD25+Foxp3+ Tregs function in an IL‐10‐dependent manner to prevent sterile cure and establish a long‐term state of functional immune privilege in the skin.