Miracle-dz/UniFAR-FTUs huggingface dataset:
Functional disability and end organ damage in patients with systemic lupus erythematosus (SLE), SLE and Sjögren's syndrome (SS), and primary SS.

OBJECTIVE To determine the accumulated end organ damage and health status in patients with SS and to compare with patients with SLE (with or without SS). METHODS Thirty-seven patients with primary SS were studied and compared with 120 patients with SLE and 21 patients with SLE and SS. The Medical Outcome Survey Short Form 20 with an additional question for fatigue was used to assess health status. The SLICC/ACR damage index with a supplementary oral section was used to assess end organ damage. For statistical analysis, logistic regression analysis, Fisher's exact test, and Kruskal-Wallis rank tests were applied. RESULTS Patients in all 3 groups had reduced quality of life with respect to all aspects of functional status and well being. There was no difference between the groups. In the primary SS group, the greatest damage was in the oral section (62% of patients). The patients with SLE and SS had the greatest renal, peripheral vascular, and musculoskeletal damage (24, 19, 38% of patients, respectively) followed by the SLE group. Ocular damage was more common in the primary SS group, but that was due to older age in this group. Malignancy was most common in the primary SS group (11%). Other organ damage scores did not differ between groups. CONCLUSION End organ damage is uncommon in primary SS (with the exception of oral damage), but the degree of functional ability is as great as in SLE.
Influence of entrapped air pockets on hydraulic transients in water pipelines

The pressure variations associated with a filling undulating pipeline containing an entrapped air pocket are investigated both experimentally and numerically. The influence of entrapped air on abnormal transient pressures is often ambiguous because the compressibility of the air pocket permits the liquid flow to accelerate but also partly cushions the system, with the balance of these tendencies being associated with the initial void fraction of the air pocket. Earlier experimental research involved systems with an initial void fraction greater than 5.8%; this paper focuses on initial void fractions ranging from 0 to 10% to more completely characterize the transient response. Experimental results show that the maximum pressure increases and then decreases as the initial void fraction decreases. A simplified model is developed by neglecting the liquid inertia and energy loss of a short water column near the air-water interface. Comparisons of the calculated and observed results show that the model is able .
Epidermal and Hepatocyte Growth Factors, but Not Keratinocyte Growth Factor, Modulate Protein Kinase Cα Translocation to the Plasma Membrane through 15(S)-Hydroxyeicosatetraenoic Acid Synthesis*

Activation of protein kinase C (PKC) involves its recruitment to the membrane, where it interacts with its activator(s). We expressed PKCα fused to green fluorescent protein and examined its real time translocation to the plasma membrane in living human corneal epithelial cells. Upon 10 min of stimulation with epidermal and hepatocyte growth factors (EGF and HGF), PKCα translocated to the plasma membrane. Keratinocyte growth factor did not stimulate PKCα translocation up to 1 h after stimulation. Pretreatment with the 15-lipoxygenase metabolite, 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE), followed by EGF or HGF, produced faster translocation of PKCα detectable at 2 min. However, the same concentration of 15(S)-HETE alone did not stimulate translocation. 15(S)-Hydroperoxyeicosatetraenoic acid and 5(S)-HETE did not affect growth factor-induced translocation of PKCα. PD153035, a specific inhibitor of tyrosine kinase activity of the EGF receptor, completely blocked PKCα translocation induced by EGF. PD98059, a specific MEK inhibitor, significantly inhibited EGF- and HGF-mediated PKCα translocation, which was reversed by addition of 15(S)-HETE. Phosphorylation of ERK1/2 by EGF was followed by phosphorylation of cytosolic phospholipase A2 (cPLA2), and blocking ERK1/2 inhibited cPLA2 activation. Immunofluorescence demonstrated translocation of p-cPLA2 to plasma and nuclear membranes as early as 2 min. This may further increase arachidonic acid release from membrane phospholipid pools and increase the intracellular pool of HETEs. In fact, in cells prelabeled with [3H]arachidonic acid, EGF stimulated synthesis of 15(S)-HETE in the cytosolic fraction. 15(S)-HETE also reversed the effect of LOX inhibitor on EGF-mediated cell proliferation. Our results indicate that 15(S)-HETE is an intracellular second messenger that facilitates translocation of PKCα to the membrane and elucidate a mechanism that plays a regulatory role in cell proliferation crucial to corneal wound healing.
Three Essays on Corporate Governance of Family Firms

This dissertation is comprised of three essays on issues related to the corporate governance of family firms. The first essay explores how owners-managers of family firms conceptualize and define their firms. Understanding the essence of a family firm helps us better understand their governance and behaviour. This essay contributes to the family business literature by presenting the seven most important criteria in identifying a family business (Handler 1989; Shanker & Astrachan 1996), namely: family ownership, control, involvement, succession, long-term vision, founders’ legacy, and extended family of employees. The essay also contributes a familiness measurement tool that can be used in future research aiming at better understanding the family firm. The second essay investigates how management control technologies are calibrated in accordance with the sometimes conflicting economic and noneconomic goals resulting from the dual identities of family firms. The results show that family firms calibrate pervasive management control technologies, such as calculative, family-centric or procedural controls to strengthen the business identity and reduce the family identity of their family business. In comparison, the minimal use, or perceived absence, of management control technologies suggest that it accentuates and fosters family identity. Hence, reverting to management control technologies becomes related in a unilateral way to the business identity of the firm, despite the dual control ambition of family firms. The third essay analyzes CEO and TMT compensation practices to identify patterns that can explain the gap between family firms and the pool of external highly qualified executives. The data analysis highlights a connection between the degree of family ownership, the composition of the BOD, and the identity of the CEO. The results also show that family firms rely more heavily on cash-based awards than on equity-based awards as a form of CEO and TMT compensation. Family firms are reluctant to use option-based rewards and the use of share-based awards is also kept at a minimum. Other evidence point towards a role that institutional ownership plays in restructuring the compensation packages of the TMTs at family firms. Keywords: Family Firms, Definition of Family Firms, Family Firm Identity, Management Control Technologies, Corporate Governance, Executive Compensation
Monodisperse Colloidal Gallium Nanoparticles: Synthesis, Low Temperature Crystallization, Surface Plasmon Resonance and Li-Ion Storage

We report a facile colloidal synthesis of gallium (Ga) nanoparticles with the mean size tunable in the range of 12–46 nm and with excellent size distribution as small as 7–8%. When stored under ambient conditions, Ga nanoparticles remain stable for months due to the formation of native and passivating Ga-oxide layer (2–3 nm). The mechanism of Ga nanoparticles formation is elucidated using nuclear magnetic resonance spectroscopy and with molecular dynamics simulations. Size-dependent crystallization and melting of Ga nanoparticles in the temperature range of 98–298 K are studied with X-ray powder diffraction, specific heat measurements, transmission electron microscopy, and X-ray absorption spectroscopy. The results point to delta (δ)-Ga polymorph as a single low-temperature phase, while phase transition is characterized by the large hysteresis and by the large undercooling of crystallization and melting points down to 140–145 and 240–250 K, respectively. We have observed size-tunable plasmon resonance in the ultraviolet and visible spectral regions. We also report stable operation of Ga nanoparticles as anode material for Li-ion batteries with storage capacities of 600 mAh g–1, 50% higher than those achieved for bulk Ga under identical testing conditions.
There Is an “I” in TEAM

Abstract We investigated narcissism as a moderator of social loafing on a physical performance task. High and low narcissistic individuals twice performed a cycling task in same-sex teams of three: once when identifiability was low; and once when identifiability was high. A significant interaction between narcissism and identifiability was revealed, F(1, 40) = 4.09, p < . 05, η2 = . 09 for performance. Follow-up tests indicated that high narcissists' performance significantly increased with greater identifiability, whereas low narcissists displayed no such performance differences. Results suggested that this effect was due to an increase in narcissists' on-task effort (ratings of perceived exertion and heart rate) when they knew that their performance was to be identified.
Sustainability through Lean Healthcare and Operational Performance in the Private Hospitals: A Proposed Framework

The Strategy Canvas that has been reported in the Eleventh Malaysia Plan, has targeted the government to improve community healthcare and yet to deliver a better service health outcomes with the strengthening collaboration among private sectors and Non-Governmental Organization (NGOs). To have a better health outcomes, lean management will be implemented to reach efficiency and optimize resources by improving work processes in the organization. But how far the private hospitals enable to survive in the long period where it can be seen the statistic of number of private hospitals is fluctuate. It indicates there are some possible factors could happen that affect the operations of the private hospitals and yet the profitability highly vulnerable. Certainly, one of the main reasons for the private hospitals is how they tolerate unnecessary waste in the organization. As such, the researcher will look deeply into how lean healthcare practices and operational performance will lead to sustainability in the private hospital by taking into account the triple bottom line; namely the financial, social, and environmental elements. Furthermore, a conceptual framework will be presented in this paper.
Focusing on facilitation: Issues and challenges of capacity development in Indonesia’s social forestry reforms

As the Indonesian government sets a target to allocate 12.7 million ha of state forest land for social forestry in 2019, one of the most crucial [and overlooked] issues is the extent of capacity, knowledge, skills, and engagement of social forestry facilitators and the extension workers that support the government in meeting their targets on social forestry. In this short paper, I seek to reorient the discussion towards the main issues and challenges of social forestry capacity development in Indonesia. On the one hand, there are some promising achievements made by the government in the wake of social forestry policy design and implementation, particularly in their ability to expand the scope of targeted areas for social forestry designation, as well as the increase in the numbers of community business group established. On the other hand, however, there are some challenges that are evident. Coordination within the ministry remains a major barrier, and extends to coordination problems across and between sub-national governments. Furthermore, engagement with the private sectors and involvement of NGOs remains lacking. And finally, the distribution of social forestry facilitators and extension workers across the numerous social forestry sites in Indonesia, as well as the overall capacity development needs among facilitators continues to be a major hindrance in meeting targets. I conclude by highlighting that more attention needs to be devoted to the role and capacity of facilitators, and furthermore, that the government needs to address these challenges through various institutional reforms and methods on social forestry training, as well as developing more rigorous training modules for community facilitators.
Renewal of the Rabbit Corneal Epithelium as Investigated by Autoradiography After Intravitreal Injection of 3H-thymidine

Purpose. To evaluate the renewal time of the rabbit corneal epithelium and to verify whether there are differences in the rate of renewal related to the topography of the cornea. Methods. After the intravitreal injection of 20 &mgr;Bq/eye of 3H-thymidine (3H-TdR), the rabbits were killed at variable survival-time intervals (3 hours to 90 days), and their corneas were processed for autoradiography on paraffin and 0.75-&mgr;m-thick Epon sections. The frequency of labeled nuclei, per each linear millimeter of epithelium, was estimated on paraffin sections of the whole length of the cornea of rabbits killed 6 hours after injection. The activity of unbound 3H-TdR was measured in the vitreous and aqueous humor. Results. The incorporation of 3H-TdR into newly synthesized DNA ceased between 1 and 2 days after the intravitreal injection. At the shortest time intervals (3 hours to 1 day), the overwhelming majority of the labeled nuclei were located in the basal stratum of the stratified squamous epithelium. Cells of the wing stratum were labeled from 3 days onward. At 14 days, labeled nuclei were visualized only in the inner portion of the surface stratum, whereas their outermost layers were labeled only at 21 days and later. Lightly labeled nuclei could still be detected in the epithelium ≤90 days after injection. The counts of labeled nuclei did not show significant differences in their frequencies between the periphery and the center of the cornea. The existence of vascularization at the periphery of the corneal stroma and the lack of a conspicuous Bowman's layer made it difficult to characterize morphologically the rabbit limbus with the light microscope. Conclusion. It takes >14 days for a daughter cell to migrate from the basal stratum to the outermost layer of the epithelium. Labeled daughter cells were detected ≤90 days in several layers of the corneal epithelium. Therefore it takes >2 weeks for the complete renewal of the epithelium. Our data suggest that the proliferative capability of the centrally located basal cells is enough to guarantee the renewal of the corneal epithelium under physiologic conditions.
Impact of accounting information on entrepreneurial decision making process

Appropriate decision making is a success, sustainability and growth factorof every enterprrise. The study evaluated the effect of accounting information on entrepreneurial decision making process among small entrepreneurs in Ogbomoso metropolis, Oyo State, Nigeria. Structured questionnaire was used to collect primary data from 120 randomly selected respondents. Simple regression analysis was used to analyze the data collected with the aid of Statistical Package for Social Sciences (SPSS) in order to evaluate the effect of independent variable (accounting information) on dependent variable (decision making). The result revealed that the use of accounting information has significant effect on the decision making process of entrepreneurs. The predictor variable (accounting information) was 69% variance of entrepreneurial decision making process. It was, therefore, recommended that small enterprise operation in Ogbomoso should embrace accounting information in order to thrive.
Effect of Corporate Social Responsibility on Performance of Manufacturing Firms in Kenya

xx 1.1 Background of the Study . 1 1.1.1 Global Perspective on CSR and Performance of Manufacturing Sector . 2 1.1.2 Regional Perspective on CSR and Performance of Manufacturing Sector . 4 1.1.3 Kenyan Perspective on CSR and Performance of Manufacturing Sector . 4 1.2 Statement of the Problem . 6 1.3 Research Objectives . 7 1.3. 1 General Objective. 7
Phase II study on Javanica oil emulsion injection (Yadanzi®) combined with chemotherapy in treating patients with advanced lung adenocarcinoma.

PURPOSE To investigate the efficacy and safety of Javanica oil emulsion injection (Yadanzi®) combined with pemetrexed and platinum (PP) for treating patients with advanced lung cancer. PATIENTS AND METHODS From June 2011 to June 2013, we recruited 58 patients with advanced lung cancer, and divided them into two groups. Twenty eight patients received Yadanzi® (from ZheJiang Jiuxu Pharmaceutical Co., Ltd.) together with PP chemotherapy (combined group), while the others were given only PP chemotherapy (control group). After two cycles of treatment, efficacy and safety of treatment were evaluated. RESULTS The overall response rate [(CR+PR+SD)/(CR+PR+SD+PD)] of the combined group was higher than that of control group (89.7% vs. 86.2%, p>0.05). Regarding rate of life improvement, it was 82.8% in combined group, and 51.7% in the control group (p<0.05). In terms of side effects, leukopenia in combined group was less frequent than that in control group (p<0.05). More patients in the control group were found to suffer liver toxicity. CONCLUSIONS Javanica oil emulsion injection combined with chemotherapy could be considered as a safe and effective regimen in treating patients with advanced lung adenocarcinoma. It can improve the quality of life and reduce the possibility of leukopenia. Further clinical trials with a large sample size should be conducted to confirm whether addition of Yadanzi® to chemotherapy could increase the response rate, reduce toxicity, enhance tolerability and improve quality of life for patients with advanced lung cancer.
Cross-cultural measurements of psychological well-being: the psychometric equivalence of Cantonese, Vietnamese, and Laotian translations of the Affect Balance Scale.

OBJECTIVES This paper evaluates the cultural equivalence of Cantonese, Vietnamese, and Laotian translations of the Affect Balance Scale. METHODS The scale was completed by 399 Vietnamese, 193 Laotian, 756 Cantonese, and 319 English speakers who were participants in the Clarke Institute-University of Toronto Refugee Resettlement Project (n = 1667). RESULTS Confirmatory factor analyses indicated a good fit between the hypothesized two-factor model (separate factors for positive and negative affect) across the original English-language version and each of the Asian-language translations. Factorial invariance (numbers and patterns of factor loadings) was evident across all versions of the scale. No evidence of item bias was detected by mixed Language x Item analyses of variance. Acceptable reliability was observed; coefficient alphas ranged from . 62 to . 72 for positive affect and from . 62 to . 70 for negative affect items. CONCLUSIONS These findings substantiate the cultural equivalence of the three translations of the scale for population health research. Important future research directions made possible by the availability of culturally equivalent instruments are discussed.
An assessment of mandatory audit firm rotation and limitation of non-audit services imposed by the Regulation (EU) No 537/2014: Evidence from Spain

: On May 27, 2014, Regulation (EU) No 537/2014 was published in the Official Journal of the European Union. Aiming to enhance audit quality, the new regulation establishes, among other measures, a maximum tenure of ten years with the audit firm and important limitations to the provision of non-audit services to audit clients by the audit firm. However, it should be noted that the extant research does not unambiguously support that long audit firm tenures or non-audit services impair the quality of audits. This research studies whether these provisions have been empirically associated with reduced audit quality for Spain. Because of its low litigation risk, the potentially negative impact of tenure and non-audit services on audit quality should be clearly observed in the Spanish audit market. Nevertheless, we do not report significantly lower levels of audit quality associated with either long tenures or non-audit services. Our results may have some interesting policy implication as they seem to put into question the necessity of such a regulation for the audit sector. ways: cross-sectional estimations of the modified-Jones’ model at the industry level; industry-panel estimations of the modified-Jones’ model with firm specific fixed effects and year specific dummy variables; and abnormal working-capital accruals computed as in Carey and Simnett (2006). In all the estimations performed, we obtain the same result (results not reported): none of the variables of interest shows any significant impact on audit quality. Therefore, we conclude that our main results are robust to how discretionary accruals are computed.
Determinants of locational patenting behavior of Canadian firms

ABSTRACT Using a unique data set combining Canadian and U.S patent data with firm-level data, we analyze Canadian firms' locational patenting decisions during the period 2000–2008. We find that the likelihood of Canadian firms' patenting in both the U.S. and Canada is associated with past patenting experience, firm size, profitability and patent scope. While manufacturing firms in export intensive industries are more likely to patent in both countries, firms in Foreign Direct Investment intensive industries are more likely to patent domestically. Finally, Canadian Intellectual Property Office's role as an International Search Authority under the Patent Cooperation Treaty (PCT) is associated with an increase in the use of PCT by Canadian firms.
Omnichannel Development within the Pakistani Fashion Retail

We examined the omnichannel Development within the Pakistani Fashion Retail and observed both Retailer and Consumer perspective in our study to see the development and Potential of Omnichannel. We selected 25 retailers (of which 22 are using multi-channels) and 224 shoppers who used more than one channel for purchasing fashion products, (due to some model fitness error we reduced our final sample size to 205 respondents). We used UTAUT2 model with 2 more predictors (perceived security and Personal innovativeness) which we found effected in purchase intention of consumer from some previous literature. As per Retailer Perspective we found that we are at an extremely early stage of omnichannel. Organizations are slowly transforming but some retailers are still under threat because of associated risks with changing their business models. Omnichannel loyalty service was found to be the weakest in current development due to profitability factors for organization which seem more important, and retailers also need to focus on data and analytics & IT structure to improve omnichannel journey. As per consumer perspective, the survey results show that the security is the main concern for the shoppers in Pakistan, it restricts shopper to provide their personal information to retailers also factors of social influence and hedonic motivation not found positively influenced in our model but habit and personal innovativeness found the key factors for omnichannel development also performance and effort expectancy founds positively influenced in the development of omnichannel. By summarizing both perspective we finally conclude (Fig. 26) that retailers should integrated their all channels in a way which gives consumer totally unified and seamless shopping experience and hit their purchase intention in a positive way which support omnichannel development in Pakistan Fashion Retail Industry. Keywords: Omnichannel, Integration, Purchase intention, transforming, loyalty services, data and analytics, Security, Effort Expectancy, Habit, Personal Innovativeness DOI : 10.7176/JMCR/54-06 Publication date :March 31 st 2019