Miracle-dz/UniFAR-FTUs huggingface dataset:
Transforming big data into knowledge: the role of knowledge management practice

Purpose The purpose of this paper is to empirically investigate how big data collected from social media contribute to knowledge management practices, innovation processes and business performance. Design/methodology/approach The study used 418 questionnaires collected from firms that actively invest in marketing, advertising and communication in the Italian market. The hypotheses testing and analysis were conducted using structural equation modeling. Findings The results reveal that customers’ data gathered from social media produce different effects on knowledge management practices and firms’ innovation capacity. Furthermore, increased innovation capacity turned out to affect customer relationship performance directly, while it contributes to gain better financial performance only when it is used to gain relational outcomes. Originality/value The outcomes of the study help firms to develop a clear understanding about which big data retrieved from social media can be useful to improve their knowledge management practices and enhance their innovation capacity. Moreover, by investigating the mediating role of big data knowledge management in the context of social media knowledge acquisition and innovation capacity, this study also extends the mediation variables used to understand the relationship between knowledge capabilities and practices and innovation constructs.
Model structure of APOBEC3C reveals a binding pocket modulating ribonucleic acid interaction required for encapsidation

Human APOBEC3 (A3) proteins form part of the intrinsic immunity to retroviruses. Carrying 1 or 2 copies of a cytidine deaminase motif, A3s act by deamination of retroviral genomes during reverse transcription. HIV-1 overcomes this inhibition by the Vif protein, which prevents incorporation of A3 into virions. In this study we modeled and probed the structure of APOBEC3C (A3C), a single-domain A3 with strong antilentiviral activity. The 3-dimensional protein model was used to predict the effect of mutations on antiviral activity, which was tested in a Δvif simian immunodeficiency virus (SIV) reporter virus assay. We found that A3C activity requires protein dimerization for antiviral activity against SIV. Furthermore, by using a structure-based algorithm for automated pocket extraction, we detected a putative substrate binding pocket of A3C distal from the zinc-coordinating deaminase motif. Mutations in this region diminished antiviral activity by excluding A3C from virions. We found evidence that the small 5.8S RNA specifically binds to this locus and mediates incorporation of A3C into virus particles.
The efficacy of adjusting the ankle in the treatment of subacute and chronic grade I and grade II ankle inversion sprains.

OBJECTIVE The purpose of this study was to determine the efficacy of adjusting the ankle in the treatment of subacute and chronic grade I and grade II ankle inversion sprains. DESIGN A single-blind, comparative, controlled pilot study. SETTING Technikon Natal Chiropractic Day Clinic. PARTICIPANTS Thirty patients with subacute and chronic grade I and grade II ankle inversion sprains. Patients were recruited from the public; they responded to advertisements placed in newspapers and on notice boards around the campus and local sports clubs. INTERVENTION Each of the 15 patients in the treatment group received the ankle mortise separation adjustment. Each of the 15 patients in the placebo group received 5 minutes of detuned ultrasound treatment. Each participant received a maximum of 8 treatment sessions spread over a period of 4 weeks. MAIN OUTCOME MEASURE Patients were evaluated at the first treatment, at the final treatment, and at a 1-month follow-up consultation. Subjective scores were obtained by means of the short-form McGill Pain Questionnaire and the Numerical Pain Rating Scale 101. Objective measurements were obtained from goniometer readings measuring ankle dorsiflexion range of motion and algometer readings measuring pain threshold over the ankle lateral ligaments. A functional evaluation of ankle function was also used. RESULTS Although both groups showed improvement, statistically significant differences in favor of the adjustment group were noted with respect to reduction in pain, increased ankle range of motion, and ankle function. CONCLUSIONS This study appears to indicate that the mortise separation adjustment may be superior to detuned ultrasound therapy in the management of subacute and chronic grade I and grade II inversion ankle sprains.
U.S. Geographic Distribution of Prevaccine Era Cervical Cancer Screening, Incidence, Stage, and Mortality

Background: Cervical cancer prevention programs are being reconfigured to incorporate human papillomavirus (HPV) testing and vaccination. To define priority areas for prevention efforts, we examined the geographic distribution of cervical cancer screening, incidence, stage, and mortality in the United States, prior to the introduction of HPV-based prevention technologies. Methods: County-level cervical cancer incidence data from 37 central registries were obtained from Surveillance, Epidemiology, and End Results and North American Association of Central Cancer Registries. A spatial–temporal model that accounted for demographic and behavioral attributes was used to generate a complete view of county-level incidence from 1995 to 2004, including counties with missing data. Distribution of stage at diagnosis was examined by registry. Counties with high mortality and infrequent screening were identified using vital statistics and newly available county-level screening estimates. Results: Compared with non-Hispanic whites and Asian and Pacific Islanders, incidence rates were higher among non-Hispanic black, American Indian and Alaska Native, and Hispanic women. Counties with infrequent screening often experienced elevated incidence and mortality rates and were located in states with suboptimal stage at diagnosis profiles. Affected areas included Appalachia, the southeastern Atlantic states, and the lower Mississippi Valley. Elevated death rates were experienced in central counties of large metropolitan areas. Conclusions: Geographic and racial/ethnic variability were evident in cervical cancer incidence and mortality. Women living in areas with endemic poverty would benefit from access to HPV-based prevention technologies. Impact: These findings provide a baseline for monitoring progress in cervical cancer control in the era of HPV-based prevention. Cancer Epidemiol Biomarkers Prev; 20(4); 591–9. ©2011 AACR.
Renewed Attention Needed for Prevention of Sudden Unexpected Death in Infancy in the Netherlands

Background: The incidence of sudden unexpected death in infancy (SUDI), which includes sudden infant death syndrome (SIDS), has declined in developed countries since the 1980s, including the Netherlands. To identify improvement opportunities in SUDI prevention, we monitored the adherence of parents to the prevention advice on infant care habits over the past 20 years, especially in relation to the SUDI incidence over time. Potential changes in parental adherence between the latest surveys are of specific interest, as these indicate where current focus is needed. Methods: Description of the prevalence of infant care factors related to the risk of SUDI, assessed from five Dutch national surveys from 1999 to 2017 among parents of infants under 12 months, and analysis of the potential differences in these prevalences between the two latest surveys in 2010/11 and 2017 with a z-test. Results: Supine sleeping position decreased from the highest prevalence of 92% in 2010/11, to 83% in 2017. Sleep sack use has increased to 55%, the highest prevalence up to now. Avoiding a duvet has remained reasonably stable since 2002/03 and now 95% of parents do not use a duvet. The prevalence of room-sharing, without sharing the bed, increased from 14% in 1999 to the highest prevalence in 2017 (31%). However, also bed-sharing almost doubled from 5.6% in 2010/11 to 10% in 2017. Breastfeeding decreased between 1999 and 2010/11, but increased from 34% in 2010/11 to 42% in 2017. An increased prevalence of mothers who abstained from smoking during pregnancy, as well as both parents not smoking, was observed, although mostly higher educated parents showed this beneficial behavior. Discussion and Conclusion: Much has already been achieved first by decreasing prone sleeping since the 80's, and subsequently promoting supine as the safest sleep position. The decrease in duvet use and smoking, and an increase in breastfeeding have also had impact. Indications of a recent decreased prevalence of the supine sleeping position and higher prevalence of bed-sharing might relate to the slightly increasing SUDI incidence in the Netherlands. Renewed attention for prevention of SUDI and specific advice targeting high-risk groups is needed. Modern, picture driven information via internet is recommended.
Trust and technology acceptance model: An experimental investigation concerning the idea contributor's acceptance of the organizational matchmaking process

The presence or absence of worthy ideas is often the reason for companies' success or failure on competitive markets. Companies invest a lot of effort into attracting stakeholder such as customers to submit their ideas to them. For this purpose companies use several open innovation channels such as idea contests, open innovation platforms and university partnerships to boost the number and quality of external ideas. After a gold-rush period of open innovation activities, external idea contributors are no longer willing to accept companies' terms and conditions. They compare companies according to how trustworthy a company or an open innovation channel is because they want to ensure that the company does not behave in an opportunistic way. Therefore, the question arises of how companies can enhance their trustworthiness, so that idea contributors are willing to submit high-quality ideas. To answer this question we conducted an experimental setting with three groups of students to understand when idea contributors trust companies' terms and conditions and submit their ideas. The results demonstrate that e.g. a mediator is able to enhance an organization's trustworthiness and therefore increase the willingness of a potential contributor to offer an idea to the selected company.
Using human intestinal biopsies to study the pathogenesis of irritable bowel syndrome

Although animal models of the irritable bowel syndrome (IBS) have provided important insights, there are no models that fully express the features of this complex condition. One alternative approach is the use of human intestinal biopsies obtained during endoscopic procedures to examine peripheral mechanisms in this disorder. These studies have served to confirm the existence of peripheral pathways in humans with IBS and have provided many new mechanistic insights. Two general approaches have been employed; one approach has been to examine the biological activity of mediators within the mucosal tissue of IBS patients and the other has been to examine changes in the structural properties of key signaling pathways contained within the biopsies. Using these approaches, important changes have been discovered involving the enteric nervous system and the extrinsic sensory pathway (dorsal root ganglia neurons), the immune system, and epithelial signaling in IBS patients compared to healthy subjects.
A new Stroop-like measure of inhibitory function development: typical developmental trends.

BACKGROUND Difficulties with inhibition are increasingly regarded as central to pathological behavioural and learning disorders in childhood. However, few measures are available to assist in the assessment of young children's inhibitory competence. METHOD A new, Stroop-like measure of inhibitory function is described which was designed to be appropriate for use with children from 3 years of age. One hundred and fifty-five school children aged between 3 and 16 years took part in a study to examine the developmental characteristics and behavioural correlates of task performance. RESULTS The task appears to provide a robust measure of inhibitory function across the age range, 3 to 16 years. Furthermore, the animal-stroop task appears to identify those at risk of hyperactive symptomatology within a school-based sample. CONCLUSIONS The clinical and developmental applications of this new measure are discussed.
Acculturation and young Iranian women: attitudes toward sex roles and intimate relationships.

This study examined the nature and extent of acculturation of Iranian women into the American culture of Los Angeles, California, their attitude toward the role of women, and their attitude toward intimate relationships. It was expected that acculturation level would be related negatively to participants' age at migration and positively related to the length of time away from Iran. Data were obtained from a sample of 77 Iranian women aged 17-32 years living in Los Angeles. Acculturation level was measured by a modified version of one designed by Cuellar, Harris, and Jasso (1980). The Sexual and Premarital Attitude Inventory designed by Schofield (1965) was used to gauge attitudes about intimate relationships. The short version of the Attitude Toward Women Scale designed by Spence, Helmreich, and Staff (1973) was used to assess differences in ideology about the role of women in society and the family. Findings indicate that acculturation level was positively associated with premarital sexual attitudes, a sex role attitude, and sex role attitudes specific to Iranians. Greater acculturation was associated with more liberal sex roles. The age at which Iranian women left Iran was negatively correlated with acculturation. Younger age was associated with a higher score. The number of years away from Iran was associated with a higher acculturation score. Educational level was not significantly related to acculturation. The author proposes that conflict between the pressure to assimilate and attachment to cultural identity may be an adaptive solution in itself. One caveat was the higher socioeconomic status of this sample population.
Where on the obsessive impulsive–compulsive spectrum does hair-pulling sisorder belong?

Abstract Objective. Hair-pulling disorder (HPD) is a putative obsessive–compulsive spectrum disorder, but proper categorization is challenging. Distinct subgroups of HPD may exist, depending on the primary motivation in the act of pulling. Two notable proposed subgroups are “relief pullers” (pulling primarily to reduce anxiety— a “compulsive” subgroup) and “pleasure/gratification pullers” (pulling primarily for reward— an “impulsive” subgroup) which we sought to examine in order to contribute to conversations on the categorization of HPD. Methods. A total of 111 HPD subjects (mean age 33.7 ± 10.7 [range 18–61] years; 87.4% female) were included. Demographic and clinical characteristics were compared between subgroups (pleasure: n = 51; relief: n = 60); and cognitive performance where data were available (n = 29 per group) and 32 matched healthy controls. Results. No significant demographic differences were noted between groups. Pleasure pullers were significantly more conscious of their pulling. Response inhibition and set shifting deficits were noted in HPD versus controls; however, pleasure and relief pullers did not differ significantly from each other on neurocognitive measures. Conclusions. The results suggest common clinical features and associated neural dysfunction between relief and pleasure/gratification pullers, rather than supporting their existence as discrete clinical entities. Selection of appropriate treatment may focus on other aspects of hair pulling, including family history and comorbidity.
Switch and Diode Fault Diagnosis in Nonisolated DC–DC Converters Using Diode Voltage Signature

Reliable operation of dc–dc converters is vital for many applications. An appropriate converter monitoring scheme is required for fault detection and adoption of effective remedial strategies. Switch faults and degradation of electrolytic capacitor account for a considerable portion of the converter failures. Although rate of diode failures is not remarkable, power switch may be damaged in case of diode fault occurrence. Furthermore, for applications in which a redundant switch is employed as a remedy, it will be also endangered by diode failures if diode fault detection has not been considered in the monitoring scheme. Therefore, diode condition monitoring improves reliability of the converter monitoring approaches. This paper presents a simple diagnosis technique for open-circuit and short-circuit faults of the switch and diode in nonisolated dc–dc converters. The technique only employs diode voltage as the detection signature. The diode voltage and gate driver signal are processed in a simple logic circuit to generate some indicators for switch and diode fault diagnosis. Basis of the technique is discussed in detail. Several experiments have been carried out on buck, boost, and buck–boost converters. The results confirm the technique capability for switch and diode fault diagnosis in less than one switching cycle.
Comprehensive Analysis of Chemical Structures That Have Been Tested as CFTR Activating Substances in a Publicly Available Database CandActCFTR

Background: Cystic fibrosis (CF) is a genetic disease caused by mutations in CFTR, which encodes a chloride and bicarbonate transporter expressed in exocrine epithelia throughout the body. Recently, some therapeutics became available that directly target dysfunctional CFTR, yet research for more effective substances is ongoing. The database CandActCFTR aims to provide detailed and comprehensive information on candidate therapeutics for the activation of CFTR-mediated ion conductance aiding systems-biology approaches to identify substances that will synergistically activate CFTR-mediated ion conductance based on published data. Results: Until 10/2020, we derived data from 108 publications on 3,109 CFTR-relevant substances via the literature database PubMed and further 666 substances via ChEMBL; only 19 substances were shared between these sources. One hundred and forty-five molecules do not have a corresponding entry in PubChem or ChemSpider, which indicates that there currently is no single comprehensive database on chemical substances in the public domain. Apart from basic data on all compounds, we have visualized the chemical space derived from their chemical descriptors via a principal component analysis annotated for CFTR-relevant biological categories. Our online query tools enable the search for most similar compounds and provide the relevant annotations in a structured way. The integration of the KNIME software environment in the back-end facilitates a fast and user-friendly maintenance of the provided data sets and a quick extension with new functionalities, e.g., new analysis routines. CandActBase automatically integrates information from other online sources, such as synonyms from PubChem and provides links to other resources like ChEMBL or the source publications. Conclusion: CandActCFTR aims to establish a database model of candidate cystic fibrosis therapeutics for the activation of CFTR-mediated ion conductance to merge data from publicly available sources. Using CandActBase, our strategy to represent data from several internet resources in a merged and organized form can also be applied to other use cases. For substances tested as CFTR activating compounds, the search function allows users to check if a specific compound or a closely related substance was already tested in the CF field. The acquired information on tested substances will assist in the identification of the most promising candidates for future therapeutics.
International Transmission of the US Interest Rate Policy Shocks: Multi-Country Model Analysis Using FAVAR

This study analyzes the international transmission of US interest rate hikes using the factor-augmented autoregression model. To achieve this purpose, this study first identifies the shocks that result from the US interest rate policies and analyzes how these shocks impact the outputs and prices in 22 countries. The shocks from the US interest rate hikes are determined to generally decrease the outputs and prices in the countries analyzed in this study. However, the current study’s analysis of the period after the global financial crisis determines that the spillover effect on price is inaccurately measured. Meanwhile, the expenditure-switching effect, which refers to the appreciation of the US dollar following an interest rate hike leading to depreciation in other currencies, thereby improving trade balance, is not considerably large. That is, the income-absorption effect (i.e., decrease in US imports owing to reduced domestic demand) or increase in world interest rate appears stronger than the expenditure-switching effect. Results suggest that the normalization of the US interest rate policy may be a factor that impedes the recovery of the global economy.
Elevator Cabin Decontamination With ACTIVE Particle Control™ Technology

Effectively reducing contamination and aerosolized bioburden may limit the risk of disease transmission in closed settings when social distancing is not possible. Unlike uncontrolled ionization and oxidation devices ACTIVE Particle Control™ conditions particles in a highly controlled fashion which provides effective air purification without the generation of ozone or other toxic by-products. The purpose of this study was to determine the impact of ACTIVE Particle Control™ on elevator cabin particle load compared to standard ventilation. The intervention trial utilized particle mass tools to determine the difference in particle clearance between standard elevator cabin ventilation and ACTIVE Particle Control™ technology. Cabin particulate contaminants were significantly reduced using ACTIVE Particle Control™ technology in an operating elevator.
Weight loss on an energy-restricted, low-fat, sugar-containing diet in overweight sedentary men

With the increasing prevalence of obesity in the United Kingdom, the search for an effective weight reducing diet is a priority in helping to reverse this trend. A 12-week dietary intervention study was carried out to test the effectiveness of an energy-restricted, low-fat, sugar-containing diet on weight loss in sedentary overweight men. The study also aimed to assess eating behaviour, to measure change in attitude towards sugar-containing foods and to measure the impact of the study on perceived quality of life. Subjects were recruited from three UK cities; Edinburgh, Birmingham and London. Seventy-six men, aged between 25 and 60 years, completed the study. Baseline diets were assessed by a 7-day diet diary. Compliance to the subsequent dietary advice was measured on four occasions post intervention, by 4-day diaries. Measures of body weight status were also monitored. Eating behaviour, attitudes towards sugar-containing foods and quality of life were assessed by questionnaire. Significant reductions in body weight (5.2%), body fat (11.2%) and waist:hip ratio (3%) were observed following reported dietary changes that included a reduction in reported energy intake of 3.2 MJ/day (770 kcal/day), a reduction in the percent energy from fat (from 38.1% to 26.2%), an increase in the percent energy from total carbohydrate (from 44.4% to 54%) and from protein (from 17.3% to 20.6%). Subjects scored relatively highly for dietary restraint and emotional eating, and were strongly influenced by external eating cues. On completion of the 12-week study, subjects had a more positive attitude towards sugar-containing foods and perceived an improved quality of life. It is concluded, therefore, that including sugar-containing foods in a weight-reducing diet may be an effective strategy to achieve a palatable, low-fat, high-carbohydrate diet, which promotes weight loss in overweight individuals.