Miracle-dz/UniFAR-FTUs huggingface dataset:
A Load-based and Due-date-oriented Approach to Order Review/Release in Job Shops

In this paper, a new order review/release (ORR) method is proposed for shop floor control systems. The proposed method utilizes both job due date and shop load information to improve the effectiveness of the ORR function in production systems. The performance of the new method is compared to those of a few well-known ORR methods under four experimental conditions. The results of extensive simulation experiments indicate that the proposed method is superior with respect to the mean absolute deviation measure. In general, it is also better than existing methods for the other performance measures. Furthermore, we show that the proposed method is more robust to variations in system load and processing times than the other ORR methods examined.
Control of the non-geometrically integral reductions

In this paper, for a geometrically integral projective scheme, we will give an upper bound of the product of the norms of its non-geometrically integral reductions over an arbitrary number field. For this aim, we take the adelic viewpoint on this subject. Résumé (Contrôle des réductions non-géométriquement intègres) Dans cet article, pour un schéma projectif géométriquement intègre, on donnera une majoration du produit des norms de ses réductions non-géométriquement intègre sur un corps de nombres arbitraire. Pour le but, on prend le point de vue adélique autour de ce sujet.
Varicella‐zoster virus antibody avidity and IgG‐subclass patterns in children with recurrent chickenpox

The normal immune response after primary varicella‐zoster virus (VZV) infection includes IgG subclass evolution to predominantly IgG1‐type antibodies, and maturation from low to high avidity antibodies which are maintained for life. Twenty‐three healthy and apparently immuno‐competent children with a history of 2‐5 episodes of chickenpox were studied after repeat disease. Serial sera were tested for VZV‐IgG subclass patterns and VZV IgG and G‐subclass antibody avidity by urea elution enzyme linked immunoassay (ELISA). Of 11 patients studied within 8 weeks of repeat chickenpox (Early Group), mean antibody avidity was significantly lower (31.3 ± 26.81) than control (65.1 ± 12.38) (P < .001). Seven had low avidity antibody (<30 percent) and an abundance of IgG3 which was a pattern like primary chickenpox, and 2/11 had high avidity antibody characteristic of anamnestic responses. Early Group patients and 12 others studied over 8 weeks after repeat disease (Late Group) showed avidity maturation and attrition of IgG subclass antibodies other than IgG1. At least nine children failed to show VZV‐specific secondary (memory) immune responses early in the course of repeat disease. It is possible that failure to maintain or evoke a secondary immune response could explain their susceptibility to repeat chickenpox. © 1994 Wiley‐Liss, Inc.
The retinoblastoma protein binds to a family of E2F transcription factors

E2F is a transcription factor that helps regulate the expression of a number of genes that are important in cell proliferation. Recently, several laboratories have isolated a cDNA clone that encodes an E2F-like protein, known as E2F-1. Subsequent characterization of this protein showed that it had the properties of E2F, but it was difficult to account for all of the suggested E2F activities through the function of this one protein. Using low-stringency hybridization, we have isolated cDNA clones that encode two additional E2F-like proteins, called E2F-2 and E2F-3. The chromosomal locations of the genes for E2F-2 and E2F-3 were mapped to 1p36 and 6q22, respectfully, confirming their independence from E2F-1. However, the E2F-2 and E2F-3 proteins are closely related to E2F-1. Both E2F-2 and E2F-3 bound to wild-type but not mutant E2F recognition sites, and they bound specifically to the retinoblastoma protein in vivo. Finally, E2F-2 and E2F-3 were able to activate transcription of E2F-responsive genes in a manner that was dependent upon the presence of at least one functional E2F binding site. These observations suggest that the E2F activities described previously result from the combined action of a family of proteins.
Investigation of phase noise of ring oscillators with time-varying current and noise sources by time-scaling thermal noise

This paper presents a new methodology of analyzing phase noise in a ring oscillator by time-scaling the thermal noise. Close-form solutions that relate the probability distribution and power-spectral density of the phase noise to circuit parameters have been obtained. These close-form solutions characterize the behavior of phase noise even when the circuit is varying with time in a nonlinear fashion. Specifically, the theory predicts that for a given oscillation frequency, phase noise roughly decreases as the cube of the delay cell charging current value at threshold crossing; thus, it provides new design insights. Simulations were run and verified this dependency.
Predictors of Outcome in Drug Treatment of Adolescent Inpatients

Little is known about for whom treatment is most effective and how to match adolescent clients to substance-abuse treatments. 280 adolescents treated in a multifaceted program participated. Of these, 128 did not complete treatment prior to termination of the 2-mo. inpatient phase. They were significantly different from clients who completed treatment measures of alienation, social maladaptation, aggression, and lower occupational status of the father. Of those who completed inpatient treatment and remained in the study at 1-mo. postdischarge (n = 69) two groups were formed, those who improved and those who either remained the same or worsened in terms of substance abuse. For those who unproved factors which differentiated them were identification with middle-class values, tendency to be older, initial difficulty identifying emotions, and depressive symptoms at intake. Clients who did not change or worsened were distinguished by more social anxiety, depressive symptoms, and troubling thoughts at intake. These results suggest that individual characteristics may identify cases who are more likely to benefit from treatment.
A continuous false belief task reveals egocentric biases in children and adolescents with Autism Spectrum Disorders

This study reports on a new false belief measure in a sample of 124 children and adolescents with or without high functioning autism (HFASD). In the classic paradigm, a participant predicts in which of two discrete locations a deceived protagonist will look for an object. In the current Sandbox task, the object is buried and reburied in a sandbox, thus creating a continuum between locations. Compared to typically developing individuals (n=62), those with HFASD (n=62) showed a larger egocentric bias on the Sandbox task. They failed to take the protagonist’s false belief into account, despite their adequate ability to infer advanced mental states. This indicates that sensitive measures can reveal subtle first order Theory of Mind impairments in HFASD individuals.
Calcium transients accompany ooplasmic segregation in zebrafish embryos

Through the injection of f‐aequorin (a calcium‐specific luminescent reporter), and the use of an imaging photon detector, transient localized elevations of free cytosolic calcium in the forming blastodisc (BD) and animal hemisphere cortex were visualized that correlated with ooplasmic segregation. The introduction of an appropriate concentration of the weak (KD= 1.5 μmol/L) calcium buffer 5,5′‐dibromo‐BAPTA results in the dissipation of these calcium domains, and inhibits cytoplasmic streaming and the subsequent formation of a BD at the animal pole. These inhibitory actions are dependent on the final cytosolic concentration of buffer within the egg: ≥ 1.3 mmol/L blocks ooplasmic streaming; < 1.3 mmol/L eggs segregate normally. Injection of 5,5′‐dimethyl‐BAPTA (KD= 0.15 μmol/L) to a final concentration of 1.5 mmol/L as a control has no effect on ooplasmic streaming. These results suggest that localized domains of elevated free cytosolic calcium are essential for ooplasmic segregation in zebrafish. Furthermore, a hypothetical model is presented linking these calcium transients to the contraction of a cortically located actin microfilament network as a possible mechanism providing the driving force for segregation.
On the design of scalable pipelined broadcasting for mesh networks

Minimising the communication latency and achieving considerable scalability are of paramount importance when designing high performance broadcast algorithms. Many algorithms for wormhole-switched meshes have been widely reported in the literature. However, most of these algorithms handle broadcast in a sequential manner and do not scale well with the network size. As a consequence, many parallel applications cannot be efficiently supported using existing algorithms. Motivated by these observations, this paper presents a new broadcast algorithm for the all-port mesh networks. The unique feature of the proposed algorithm is its capability of handling broadcast in only one message-passing step irrespective of the network size. Results from a comparative analysis and simulation reveal that the proposed algorithm exhibits superior performance characteristics over those of the well-known Recursive Doubling, Extending Dominating Node and Network Partitioning algorithms.
Identification of N-acyl-fumonisin B1 as new cytotoxic metabolites of fumonisin mycotoxins.

SCOPE Fumonisins are mycotoxins produced by Fusarium species. The predominant derivative, fumonisin B1 (FB1), occurs in food and feed and is of health concern due to its hepatotoxic and carcinogenic effects. However, the role of FB1 metabolites on the mechanism of the toxicity, the inhibition of the ceramide synthesis, is unknown. The aim of this study was to identify new fumonisin metabolites and to evaluate their cytotoxic potential. METHODS AND RESULTS MS, molecular biology, and in vitro enzyme assays were used to investigate fumonisin metabolism in mammalian cells overexpressing human ceramide synthase (CerS) genes. N-acyl-FB1 derivatives were detected as new metabolites in cultured cells at levels of up to 10 pmol/mg of protein. The N-acylation of FB1 and hydrolyzed FB1 was analyzed in several cell lines, including cells overexpressing CerS. The acyl-chain length of the N-acyl fumonisins depends on the CerS isoform acylating them. The N-acyl fumonisins are more cytotoxic than the parent fumonisin B1. CONCLUSION The identification of N-acyl fumonisins with various acyl chain lengths together with the observed cytotoxicity of these compounds is a new aspect of fumonisin-related toxicity. Therefore, these new metabolites might play an important role in the mode of action of fumonisins.
Returns to Integrated Pest Management Research and Outreach for Soybean Aphid

ABSTRACT Soybean aphid, Aphis glycines Matsumura, is a major invasive pest that has caused substantial yield loss and increased insecticide use in the United States since its discovery in 2000. Using the economic surplus approach, we estimate the economic benefits of U.S. research and outreach for integrated pest management (IPM) of soybean aphid. We calculate ex ante net benefits from adoption of an IPM economic threshold (ET). The ET triggers insecticide application only if the value of predicted yield damage from pest scouting is expected to exceed the cost of pest control. Our research finds that gradual adoption of an ET for soybean aphid management will generate a projected economic net benefit of $1.3 billion, for an internal rate of return of 124%, over the 15 yr since soybean aphid IPM research began in 2003. Lower and upper bound sensitivity analysis brackets the estimated net benefit to U.S. consumers and soybean, Glycine max (L.) Merr. , growers in the range of $0.6 to $2.6 billion in 2005 dollars. If a 10% rate of return is attributed to IPM applied research and outreach on soybean aphid, that would leave nearly $800 million to compensate prior activities that contribute to the development and adoption of IPM.
Anencephaly and twins

Budorick NE, Pretorius DH, McGahan JP, Grafe MR, James HE, Slivka J. 1995. Cephalocele detection in utero: sonographic and clinical features. Ultrasound Obstet Gynecol 5: 77–85. Cullen MT, Athanassiadis AP, Romero R. 1990. Prenatal diagnosis of anterior parietal encephalocele with transvaginal sonography. Obstet Gynecol 75: 489–491. Goldstein RB, LaPidus AS, Filly RA. 1992. Fetal cephaloceles: diagnosis with ultrasound. Radiology 180: 803–808. Graham D, Johnson TRB, Winn K, Sanders RC. 1982. The role of sonography in the prenatal diagnosis and management of encephalocele. J Ultrasound Med 1: 111–115. Mueller GM, Weiner CP, Yankowitz J. 1996. Three-dimensional ultrasound in the evaluation of fetal head and spine anomalies. Obstet Gynecol 88: 372–378.
High CDK6 Protects Cells from Fulvestrant-Mediated Apoptosis and is a Predictor of Resistance to Fulvestrant in Estrogen Receptor–Positive Metastatic Breast Cancer

Purpose: Resistance to endocrine therapy in estrogen receptor–positive (ER+) breast cancer remains a major clinical problem. Recently, the CDK4/6 inhibitor palbociclib combined with letrozole or fulvestrant was approved for treatment of ER+ advanced breast cancer. However, the role of CDK4/6 in endocrine resistance and their potential as predictive biomarkers of endocrine treatment response remains undefined. Experimental Design: We investigated the specific role of increased CDK6 expression in fulvestrant-resistant cells by gene knockdown and treatment with palbociclib, and evaluated the effect in cell proliferation, apoptosis, and kinase activity. Furthermore, we evaluated CDK6 expression in metastatic samples from breast cancer patients treated or not with fulvestrant. Results: We found increased expression of CDK6 in two fulvestrant-resistant cell models versus sensitive cells. Reduction of CDK6 expression impaired fulvestrant-resistant cell growth and induced apoptosis. Treatment with palbociclib resensitized fulvestrant-resistant cells to fulvestrant through alteration of retinoblastoma protein phosphorylation. High CDK6 levels in metastatic samples from two independent cohorts of breast cancer patients treated with fulvestrant (N = 45 and 46) correlated significantly with shorter progression-free survival (PFS) on fulvestrant treatment (P = 0.0006 and 0.018), whereas no association was observed in patients receiving other first- or second-/third-line endocrine treatments (N = 68, P = 0.135 and 0.511, respectively). Conclusions: Our results indicate that upregulation of CDK6 may be an important mechanism in overcoming fulvestrant-mediated growth inhibition in breast cancer cells. Patients with advanced ER+ breast cancer exhibiting high CDK6 expression in the metastatic lesions show shorter PFS upon fulvestrant treatment and thus may benefit from the addition of CDK4/6 inhibitors in their therapeutic regimens. Clin Cancer Res; 22(22); 5514–26. ©2016 AACR.
Videoradiographic, manometric, and electromyographic analysis of canine upper esophageal sphincter.

We assessed upper esophageal sphincter (UES) function in dogs by concurrent recording of cricopharyngeal electromyographic (EMG) activity, intraluminal pressure, and dimensional changes of the pharyngoesophageal junction at rest and during swallowing. Radial and axial pressure profiles of the UES were determined by continuous pull-through manometry. EMG activity of the cricopharyngeus and thyropharyngeus muscles were correlated with UES pressure under static conditions. We also quantified the temporal relationships among EMG activity of the cricopharyngeus, UES pressure, and pharyngoesophageal junction dimensional changes during swallowing of 2, 4, and 6 ml of barium. When the dogs were prone, the anterior and posterior UES pressures were about twice the lateral pressures and the axial length of the UES was approximately 4 cm. All radial pressures equalized to approximately 20 mmHg when the dogs lay on their sides. The peak pressure zone of the UES corresponded closely with the level of the cricopharyngeal electrode, and resting UES pressure correlated closely with cricopharyngeal but not thyropharyngeal EMG activity. During swallowing, the cricopharyngeus relaxed approximately 200 ms before UES opening and 100 ms before UES relaxation. Superior movement of the hyoid and the larynx was associated temporally with UES relaxation, while anterior movement was associated with UES opening. Increases in bolus volume significantly increased maximal sagittal UES diameter during UES opening but did not alter temporal changes in UES function. (ABSTRACT TRUNCATED AT 250 WORDS)
Review of the health effects of wildland fire smoke on wildland firefighters and the public

Abstract Each year, the general public and wildland firefighters in the US are exposed to smoke from wildland fires. As part of an effort to characterize health risks of breathing this smoke, a review of the literature was conducted using five major databases, including PubMed and MEDLINE Web of Knowledge, to identify smoke components that present the highest hazard potential, the mechanisms of toxicity, review epidemiological studies for health effects and identify the current gap in knowledge on the health impacts of wildland fire smoke exposure. Respiratory events measured in time series studies as incidences of disease-caused mortality, hospital admissions, emergency room visits and symptoms in asthma and chronic obstructive pulmonary disease patients are the health effects that are most commonly associated with community level exposure to wildland fire smoke. A few recent studies have also determined associations between acute wildland fire smoke exposure and cardiovascular health end-points. These cardiopulmonary effects were mostly observed in association with ambient air concentrations of fine particulate matter (PM2.5). However, research on the health effects of this mixture is currently limited. The health effects of acute exposures beyond susceptible populations and the effects of chronic exposures experienced by the wildland firefighter are largely unknown. Longitudinal studies of wildland firefighters during and/or after the firefighting career could help elucidate some of the unknown health impacts of cumulative exposure to wildland fire smoke, establish occupational exposure limits and help determine the types of exposure controls that may be applicable to the occupation.
Differential Microstrip Antenna for RF Energy Harvesting

A differential microstrip antenna with improved gain for RF energy harvesting is presented in this paper. The developed antenna can be used in either center grounded or differential configuration. The antenna is designed and fabricated for GSM900 band (890-960 MHz). The antenna has a gain of 8.5 dBi at the center frequency and exhibits VSWR ≤ 2 for frequencies between 870 MHz to 1.05 GHz. The efficiency of the antenna is 80%. The developed antenna finds its application in energy harvesting, RFID tags and in wireless communication circuits, where differential inputs/outputs are needed. A complete differential RF energy harvesting system with a peak efficiency of 65.3% for a load of 3 kΩ is also developed.
Effects of thermal stress on hybrid perovskite solar cells with different encapsulation techniques

We subjected to both storage and thermal stress solid state solar cells based on organometal perovskites and using Spiro-OMeTAD as hole transport material. We applied two different sealing techniques to encapsulate the devices, in order to study the differences during the experiment. Applying both fast ciclo-voltammetry, transient measurement and very slow DC measurements, we correlated the results obtained during the 540h experiment to different degradation dynamics within the cell structure. The correlation allows us to distinguish at least two possible sources of degradation that can help understand loss mechanisms of perovskite solar cells.
Taylor and Bi-local Piecewise Approximations with Neuro-Fuzzy Systems

Methods of local approximations based on truncated Taylor series are well understood; several methods to compute bounds for the approximation errors are available (Christensen and Christensen, 2006), (Powell, 1981), (Shahriari, 2006). The use of Taylor approximations is convenient, among others, because methods to determine the approximation accuracy are well established. Taylor approximations are widely used in solving differential equations (Kloeden, Platen, 1995), (Tachev, 2009), control applications (Hedjar et al., 2005), circuit modeling (Jridi and Alfalou, 2009), data processing, image generation, signal prediction (Hedjar et al., 2005), and economic modeling (Judd, 1998).
Design and Performance Evaluation of IPoIB Gateway

InfiniBand provides a high-bandwidth, low-latency network, and has been widely adopted in modern storage and computing systems. However, Ethernet fabric is still widely used which has different characteristics in protocol and performance. Therefore, an Ethernet-to-InfiniBand gateway must be built to implement protocol conversion and bandwidth aggregation. This paper introduces a software implementation of Ethernet-to-InfiniBand gateway based on IPoIB protocol. Moreover, several network test tools are compared and used to evaluate the performance of IPoIB gateway. Performance evaluation results show that IP fragmentation operations and high CPU utilization of software interruption are the bottlenecks of the system, and they are good references for the design of hardware Ethernet-to-InfiniBand gateway
Organic Wheat Farming Improves Grain Zinc Concentration

Zinc (Zn) nutrition is of key relevance in India, as a large fraction of the population suffers from Zn malnutrition and many soils contain little plant available Zn. In this study we compared organic and conventional wheat cropping systems with respect to DTPA (diethylene triamine pentaacetic acid)-extractable Zn as a proxy for plant available Zn, yield, and grain Zn concentration. We analyzed soil and wheat grain samples from 30 organic and 30 conventional farms in Madhya Pradesh (central India), and conducted farmer interviews to elucidate sociological and management variables. Total and DTPA-extractable soil Zn concentrations and grain yield (3400 kg ha-1) did not differ between the two farming systems, but with 32 and 28 mg kg-1 respectively, grain Zn concentrations were higher on organic than conventional farms (t = -2.2, p = 0.03). Furthermore, multiple linear regression analyses revealed that (a) total soil zinc and sulfur concentrations were the best predictors of DTPA-extractable soil Zn, (b) Olsen phosphate taken as a proxy for available soil phosphorus, exchangeable soil potassium, harvest date, training of farmers in nutrient management, and soil silt content were the best predictors of yield, and (c) yield, Olsen phosphate, grain nitrogen, farmyard manure availability, and the type of cropping system were the best predictors of grain Zn concentration. Results suggested that organic wheat contained more Zn despite same yield level due to higher nutrient efficiency. Higher nutrient efficiency was also seen in organic wheat for P, N and S. The study thus suggests that appropriate farm management can lead to competitive yield and improved Zn concentration in wheat grains on organic farms.