Miracle-dz/UniFAR-FTUs huggingface dataset:
Peasant Russia Civil War: The Volga Countryside in Revolution 1917-21

Part I The emergence of peasant autonomy: the end of the Old Regime peasant assemlies the Jacquery and its organization the establishment of the "Volost" Soviets. Part 2 Six months of peasant rule: the structure of Soviet power in the countrside the "volost" Soviets and the food crisis land reform a village democracy or a democracy of the farming peasantry? Part 3 Counter-revolution: the "Kulak counter-revolution" the peasantry and the Samara government "Komuch". Part 4 Rural politics during the Civil War: the committees of the rural poor ("Kombedy") the village and "Volust" Soviet elections of 1919 the Bolshevik party - a note on its membership in the rural areas the transformation of the Soviets. Part 5 The rural economy under war communism: food procurement peasant agriculture rural industry collective and state forms the peasantry and the Red Army. Part 6 Peasant wars: the wars of the "Chapany" and the Black Eagle Sapozhkov banditry.
T-wave and heart rate variability changes to assess training in world-class athletes.

PURPOSE A decrease of electrocardiographic T-wave voltage with increasing training loads has been reported in elite endurance athletes and ascribed to training-related adaptation in sympathetic activity to the ventricles. A switch from vagal to sympathetic predominance in sino-atrial node regulation on going from low to peak training load has been reported in world-class rowers. In this study on world-class endurance athletes, we tested the hypothesis that training-induced variations in T-wave amplitude at higher training loads are paralleled by changes in HR spectral profile. METHODS We studied eight male rowers of the Italian national team in the season culminating with the Rowing World Championship. Athletes were evaluated at 50 and 100% of training load, approximately 20 d before the World Championship, and during the World Championship, when the intensity was markedly reduced. We assessed T-wave maximum amplitude in chest lead V6 and cardiac autonomic regulation by power spectral analysis of R-R interval variability. RESULTS The increase in training load from 50 to 100% was accompanied by a significant decrease in high frequency and a significant increase in low-frequency R-R variability (in normalized units) with a concomitant significant decrease in T-wave amplitude (microV). Reduction in training load during the World Championship resulted in a return of spectral profile to the level observed at 50% training load and in a partial recovery of T-wave amplitude. HR did not change significantly. CONCLUSIONS In high-performance world-class athletes, training load simultaneously affects both ventricular repolarization and HR variability patterns possibly through variations in cardiac sympathetic modulation to the ventricles and the sino-atrial node. Information on concomitant changes in ventricular repolarization and autonomic cardiac regulation might be employed to tailor training protocols of elite athletes.
MR-based measurements of portal vein flow and liver stiffness for predicting gastroesophageal varices.

OBJECTIVES We evaluated flow parameters measured by phase-contrast magnetic resonance (MR) imaging (PC-MRI) of the portal venous system and liver stiffness measured by MR elastography (MRE) to determine the usefulness of these methods in predicting gastroesophageal varices (GEV) in patients with chronic liver disease (CLD). METHODS In patients with CLD and controls, we performed PC-MRI on the portal (PV) and superior mesenteric veins; calculated mean velocity (V, cm/s), cross-sectional area (S, mm²), and flow volume (Q, mL/min); and determined markers of liver fibrosis (liver stiffness [kPa]) and aspartate aminotransferase (AST) platelet ratio index [APRI]). We visually assessed GEV and development of collateral pathways of the PV on routine contrast-enhanced dynamic MR imaging and compared patient characteristics, flow parameters, liver stiffness markers, and visual analysis among 3GEV groups, those with mild, severe, or no GEV with reference to endoscopic findings. RESULTS Child-Pugh grade, VPV, SPV, liver stiffness, APRI, and visually identified GEV (visible GEV) differed significantly among the 3 groups (P<0.05). We investigated VPV, SPV, liver stiffness, and visible GEV as independent markers to distinguish patients with and without GEV and examined VPV and visible GEV to predict severe GEV. Visible GEV showed low sensitivity (14 to 30%) and high specificity (98%) for predicting GEV in patients with CLD. A subgroup analysis that excluded cases with collateral pathway demonstrated slightly improved diagnostic performance of VPV and liver stiffness. CONCLUSIONS Portal vein flow parameters and liver stiffness can be useful markers for predicting GEV in patients with CLD.
Evidence of baroreflex adaptation to repetitive +Gz in fighter pilots.

BACKGROUND The arterial baroreflex acts to maintain arterial pressure in the face of an orthostatic challenge. The high +Gz loads experienced by fighter pilots represent an extreme form of orthostatic challenge. G-induced loss of consciousness (G-LOC) represents a failure of the baroreflex system to maintain the appropriate level of cerebral perfusion. The anecdotal experience of fighter pilots is that their cardiovascular systems adapt to frequent exposure to high +Gz levels. HYPOTHESIS The purpose of this study was to demonstrate that the baroreflex-mediated cardiovascular response of a group of 8 fighter pilots to a mild accelerative stimulus differs from that of a group of 12 non-pilots. METHODS Arterial pressures and heart rate responses to rapid head-up tilting to +75 degrees were compared between the two groups. Five variables were examined: systolic, diastolic, mean arterial and pulse pressures, and heart rate. RESULTS The cardiovascular responses of the groups were fundamentally different. In response to tilt, the non-pilots showed little change in systolic and mean arterial pressures, diastolic pressure increased slightly and pulse pressure decreased significantly. In the pilot group, however, significant increases were observed in systolic, diastolic and mean arterial pressures (p < 0.05), whereas pulse pressure did not change. Between groups there were significant differences observed in terms of arterial pressures (p < 0.05), but not heart rate. CONCLUSION The baroreflex of a fighter pilot is capable of adapting to +Gz, becoming a more sensitive and effective BP control system as a result. This adaptation affords the pilot greater protection against G-LOC.
Pharmacokinetics and Pharmacodynamics of Oral Heparin Solid Dosage Form in Healthy Human Subjects

The present investigation determined the molecular structure and the pharmacokinetic and pharmacodynamic profiles of oral unfractionated heparin containing oral absorption enhancer sodium N‐[8‐(2‐hydroxybenzoyl) amino]caprylate, salcaprozate sodium (SNAC) and assessed the safety and tolerability of the orally dosed heparin solid dosage form versus other routes. Sixteen healthy men were included in this single‐dose, 3‐way crossover, randomized, open‐label study. Disaccharide compositional analysis was performed using capillary high‐performance liquid chromatography with electrospray ionization mass spectrometry detection. The pharmacodynamics of heparin were obtained from analysis of plasma anti–factor Xa, anti–factor IIa, activated partial thromboplastin time, and total tissue factor pathway inhibitor data. The molecular weight properties and the disaccharide composition of orally administered unfractionated heparin/SNAC and parenterally administered unfractionated heparin are identical and consistent with the starting pharmaceutical standard heparin. Furthermore, the anti–factor Xa/anti–factor IIa ratio achieved is of approximately 1:1. This is the first true pharmacokinetic study to measure the chemical compositions of heparin administered by different routes.
[Being online without a purpose -- study of background variables of problematic internet use].

BACKGROUND AND AIMS OF THE STUDY These days, use of the Internet is unavoidable for the younger generations. The online world is the primary source of infomation and quick communication, and these activities can take many hours per day. The main goal of the present study was to examine the correlations among problematic internet use, social factors, stress and life satisfaction. METHOD Data collection was going online during the first semester of the year 2014 (N= 386 girls). The anonymous questionnaire contained items on perceived social support and the amount of online activites beyond sociodemographics. After descriptive statistics, factor, correlation and multiple linear regression analyses were applied to detect interrelationships. RESULTS According to our data, 78% of the participants spent daily at least 2 hours, 40% more than 4 hours online. Using factor analysis, four factors of online activities were identified: Social networking-surfing, News-information, Risky and Lonely game factors. Only the News-information factor was not related to the problematic internet use. Based on multiple regression analyses, we may conclude that shyness, stress, loneliness and two factors, the Social networking-surfing and the Risky factors acted as background variables for problematic internet use. CONCLUSIONS As a summary we may conclude that the internet has an important role in the everyday life of the participants. In case of the direct aim of the online activities the problematic use did not appear. These activities were mostly searching for information and news. In introduction of prevention, education about the correct use of the internet may be reasonable as early as possible.
Hedging and Pricing Rent Risk with Search Frictions

The desire of risk-averse households to hedge rent risk is thought to increase home ownership and prices. While evidence for the ownership implication is compelling, support for the price effect is mixed. We show that an important reason is search frictions. Rent risk reduces outside options, leading to less-picky buyers and worse home/buyer matches. This attenuates the rise in the price-to-rent ratio that would otherwise occur without frictions. Consistent with our model, a house remains on the market for fewer days when rent risk is higher. Accounting for frictions significantly increases the effect of rent risk on home prices.
The Cognitive Side Effects of Modern ECT: Patient Experience or Objective Measurement?

This article explores the subjective experience of cognitive deficits of patients who are treated with electroconvulsive therapy, by using actual comments made in clinical situations. The material is divided into 4 themes: the need for clear information, the importance of validation of experience, the impact of daily disruptions, and the issue of self-esteem. It is argued that despite the low correlation which exists between objectively measured cognitive function and the subjectively experienced impairment, the discrepancy creates a need to take both perspectives into consideration rather than to rely on one or the other. The validity and limitations of using personal narrative as a relevant clinical parameter are discussed.
Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy.

UNLABELLED It remains unclear how obesity worsens treatment outcomes in patients with pancreatic ductal adenocarcinoma (PDAC). In normal pancreas, obesity promotes inflammation and fibrosis. We found in mouse models of PDAC that obesity also promotes desmoplasia associated with accelerated tumor growth and impaired delivery/efficacy of chemotherapeutics through reduced perfusion. Genetic and pharmacologic inhibition of angiotensin-II type-1 receptor reverses obesity-augmented desmoplasia and tumor growth and improves response to chemotherapy. Augmented activation of pancreatic stellate cells (PSC) in obesity is induced by tumor-associated neutrophils (TAN) recruited by adipocyte-secreted IL1β. PSCs further secrete IL1β, and inactivation of PSCs reduces IL1β expression and TAN recruitment. Furthermore, depletion of TANs, IL1β inhibition, or inactivation of PSCs prevents obesity-accelerated tumor growth. In patients with pancreatic cancer, we confirmed that obesity is associated with increased desmoplasia and reduced response to chemotherapy. We conclude that cross-talk between adipocytes, TANs, and PSCs exacerbates desmoplasia and promotes tumor progression in obesity. SIGNIFICANCE Considering the current obesity pandemic, unraveling the mechanisms underlying obesity-induced cancer progression is an urgent need. We found that the aggravation of desmoplasia is a key mechanism of obesity-promoted PDAC progression. Importantly, we discovered that clinically available antifibrotic/inflammatory agents can improve the treatment response of PDAC in obese hosts. Cancer Discov; 6(8); 852-69. ©2016 AACR.See related commentary by Bronte and Tortora, p. 821This article is highlighted in the In This Issue feature, p. 803.
Impact of IDH1 R132 mutations and an IDH1 single nucleotide polymorphism in cytogenetically normal acute myeloid leukemia: SNP rs11554137 is an adverse prognostic factor.

PURPOSE We assessed the prognostic impact of IDH1 R132 mutations and a known single nucleotide polymorphism (SNP) located in the same exon of the IDH1 gene in patients with cytogenetically normal acute myeloid leukemia (CN-AML) in the context of other prognostic markers. PATIENTS AND METHODS IDH1 exon four was directly sequenced in 275 CN-AML patients from two subsequent AML multicenter treatment trials and 120 healthy volunteers. Moreover, mutations in NPM1, FLT3, CEBPA, and WT1 were analyzed, and mRNA expression of IDH1 was quantified. RESULTS IDH1 R132 mutations were found in 10.9% of CN-AML patients. IDH1 SNP rs11554137 was found in 12% of CN-AML patients and 11.7% of healthy volunteers. IDH1 R132 mutations had no impact on prognosis. In contrast, IDH1 SNP rs11554137 was an adverse prognostic factor for overall survival in univariate and multivariate analysis. Other significant factors were age, NPM1/FLT3 mutational status, WT1 SNP rs16754, and platelet count. The impact of IDH1 SNP rs11554137 was most pronounced in the NPM1/FLT3 high-risk patients (either NPM1 wild-type or FLT3-internal tandem duplication positive). Patients with IDH1 SNP rs11554137 had a higher expression of IDH1 mRNA than patients with two wild-type alleles. CONCLUSION IDH1 SNP rs11554137 but not IDH1 R132 mutations are associated with an inferior outcome in CN-AML.
Arabic information retrieval: Stemming or lemmatization?

The Arabic language is expanding in the world. According to UNESCO, the Arabic language is spoken by more than 422 million native speakers around 29 countries and among 1.6 billion Muslims worldwide use it to perform their daily prayers. The presence of the Arabic language on the internet grew around 6.091% in the last fifteen years (2000–2015), it is the highest growth of the ten top online languages. Therefore, the number of Arabic documents increases rapidly. This calls for the necessity to improve Arabic Information Retrieval (IR) techniques. Many researchers agree on the benefits of both stemming and lemmatization in IR, primarily with highly inflective languages, short documents and limited space for storing data. The chief purpose of the current study is assessing the impact of stemming and lemmatization on Arabic IR. In this paper, we illustrate several concepts of Arabic morphology, including stemming and lemmatization algorithms. Then, we highlight the use of these latter and their benefits for different Arabic IR systems. Finally, an experiment is conducted to calculate the occurrence of all Quranic surface word, stem, and lemma forms by searching their similarities in both Classical and Modern Standard Arabic resources. In doing so, recent and efficient analyzers AlKhalil Morpho Sys and MADAMIRA are used.
Risk of early progression to prediabetes or diabetes in women with recent gestational dysglycaemia but normal glucose tolerance at 3‐month postpartum

Objective Both gestational diabetes mellitus (GDM) and milder glucose intolerance in pregnancy identify women who are at risk of developing type 2 diabetes. While some of these women will have prediabetes or diabetes in the early postpartum, most will have normal glucose tolerance (NGT), despite their future diabetic risk. In this context, we sought to evaluate the risk of early progression to dysglycaemia in women with NGT at 3‐month postpartum and identify predictors thereof.
Recurrent hepatocellular carcinoma in liver transplant recipients: parameters affecting time to recurrence, treatment options and survival in the sorafenib era.

BACKGROUND A growing number of patients with hepatocellular carcinoma undergo liver transplantation, but there is little data on recurrence and its treatment in the posttransplant setting. METHODS This article presents a retrospective analysis of adult hepatocellular carcinoma patients. The aim of the study was to characterize the clinical pattern of posttransplant hepatocellular carcinoma recurrence, treatment options in recurrence and overall survival after liver transplantation and after recurrence. RESULTS A total of 139 patients with histological proven hepatocellular carcinoma was included in the study. The median follow-up after liver transplantation was 37.2 months. Twenty-four of 139 patients experienced a recurrence. In 72.7% of the cases, the hepatocellular carcinoma recurred outside the transplant. Median overall survival after recurrence was 23.1 months. A total of 68.2% of patients received a mean of 2.2 treatments for posttransplant hepatocellular carcinoma recurrence. While on treatment with sorafenib, the use of mTOR inhibitors and radiotherapy had no statistically significant effect on overall survival, complete surgical resection of metastatic lesions significantly improved overall survival. Non-resectable patients with isolated hepatic relapse also benefited from local control strategies. CONCLUSIONS Posttransplant hepatocellular carcinoma recurrence frequently is located outside the transplant, and despite the proven efficacy of sorafenib, complete surgical resection of metastatic lesions remains the hallmark of treatment.
Rehabilitation students' attitudes toward persons with disabilities in high- and low-stakes social contexts: A conjoint analysis

Purpose. The primary objective of this research is to examine factors influencing rehabilitation services students' attitudes toward people with disabilities in two social contexts using a conjoint analysis design. Method. Ninety-nine students in rehabilitation counselling participated in a conjoint measurement study featuring 55 stimulus cards representing varying disability types, genders, races or ethnicities, grade point averages, internship evaluations, and employment statuses for both high-stakes scenarios and low-stakes scenarios. The participants were instructed to order the stimulus cards to indicate their preferences for associating with different people with disabilities in two social contexts: A high-stakes context as a rehabilitation administrator hiring a counsellor and a low-stakes context as a mentor/companion. Results. The results showed that age and disability type were most involved in the decision-making process in the low-stakes group, and performance-related variables were most important in the high-stakes context. Attitude was significantly affected by client characteristics unrelated to disability including age and race or ethnicity, and factors influencing attitude formation differed across the two social contexts. Conclusion. Conjoint analysis can contribute to our understanding of the formation of attitudes or preferences in multiple social contexts. Using these results, it may be possible to develop effective attitude change strategies.
High prevalence of diabetes mellitus among adult beta-thalassaemic patients with chronic hepatitis C.

AIM The aim of this study was to assess the prevalence of diabetes mellitus in patients with hepatitis C virus (HCV) chronic hepatitis and secondary haemochromatosis as a consequence of beta-thalassaemia major. This group of patients was studied in order to reveal subtle effects of early stages of HCV infection on glucose metabolism, made more apparent by the coexistence of the diabetogenic effect of haemochromatosis. PATIENTS AND METHODS The study included 108 beta-thalassaemic multitransfused patients, 55 females and 53 males, age 26.8+/-9 years. Sixty-four patients were seropositive for HCV by ELISA-3 (61/64 HCV-polymerase chain reaction-positive by Amplicor). In 51 of these, chronic hepatitis C was documented by liver biopsy, which also showed incomplete cirrhosis for eight and cirrhosis for four patients. Diabetes was diagnosed according to the criteria of the National Diabetes Data Group of the National Institutes of Health. RESULTS (1) Patients with thalassaemia and HCV infection were diabetic more often than thalassaemic patients without HCV infection (45.3% versus 11.3%; P<0.001). This highly significant difference was also found when patients with definite cirrhosis or incomplete cirrhosis were excluded (41% versus 11.3%; P<0.01). (2) The high frequency of diabetes in thalassaemic patients with HCV chronic hepatitis is not related to body mass index or iron load, but it seems especially evident in patients over 25 years of age (50% of HCV-positive were diabetic versus 9.5% of HCV-negative; P<0.01). CONCLUSION The frequency of diabetes in adult thalassaemic patients is significantly increased by HCV infection, even in the absence of cirrhosis. It is probable that the coexistence of haemochromatosis makes the effect of HCV infection on glucose metabolism clinically evident, even in the stage of chronic hepatitis.