Miracle-dz/UniFAR-FTUs huggingface dataset:
The Relationship Between Children’s Concept of Word in Text and Phoneme Awareness in Learning to Read: A Longitudinal Study

Using a longitudinal design, this study tested a developmental hypothesis about the growth of word knowledge in kindergarten readers. Based on previous work (Henderson, 1980; Morris, 1980, 1983), it was predicted that beginning consonant knowledge (BC) facilitates a child's concept of word in text (CW), which in turn facilitates phoneme segmentation (PS), which in turn facilitates word recognition (WR). Fifty-three kindergartners were tested at two-month intervals during the school year on BC, CW, PS, and WR tasks. The results of two different analyses provided convergent support for the developmental hypothesis (BC-*CW->PS-> WR). Generalizability of the results is limited by the specific kindergarten instructional contexts in this study. Nonetheless, the findings do highlight some interesting relationships between beginning readers' emerging phonological awareness and their understanding of how spoken words map to printed words in text.
Referral of children with otitis media. Do family physicians and pediatricians agree?

OBJECTIVE To determine factors influencing family physicians' and pediatricians' decisions to refer children with recurrent acute otitis media (RAOM) and otitis media with effusion (OME) to otolaryngologists for an opinion about tympanostomy tube insertion. DESIGN Mailed survey. SETTING Physicians' practices in Ontario. PARTICIPANTS Random sample of 1459 family physicians and all 775 pediatricians in the province. MAIN OUTCOME MEASURES Physicians' reports of the influence of 17 factors on decisions to refer (more likely, no influence, less likely to refer) and number of episodes of otitis media, months with effusion, level of hearing loss, or months of continuous antibiotics without improvement prompting referral. RESULTS Physicians agreed (> 80% concordance) on six out of 17 factors as indications for referring children with RAOM or OME. Opinions about the importance of other factors varied widely. Family physicians would refer children with otitis media after fewer episodes of illness, fewer months of effusion, lower levels of hearing loss, and fewer months of prophylactic antibiotic therapy than pediatricians (all P < .001). Pediatricians would prescribe continuous antibiotics longer (11.8 weeks) than family physicians (8.9 weeks, P < .0001), which correlated with lower referral thresholds for family physicians. CONCLUSION Family physicians' and pediatricians' self-reported referral practices for surgical opinions on children with otitis media varied considerably. These observations raise questions about the consistency of care for children with otitis media and whether revised clinical guidelines would be helpful.
Metabolomics in Nutrition Research: Biomarkers Predicting Mortality in Children with Severe Acute Malnutrition

Background Millions of the world's children suffer from malnutrition, which predisposes to death from diarrhea and a variety of infectious diseases. Mortality rates among infants and toddlers remain staggeringly high, in part because the pathogenesis of acute malnutrition and its complications remains poorly understood. Objective We used metabolomic analysis to characterize the metabolic status of Ugandan children with severe acute malnutrition (SAM) and to delineate changes in hormones, metabolites, growth factors, and cytokines during nutritional therapy. We hypothesized that hormonal and metabolic factors measured at presentation would associate with, or predict, subsequent mortality during treatment Methods This was a prospective cohort study of 75 severely malnourished children 6 months to 5 years of age treated as inpatients with F-75 and F-100 and supplemental micronutrients; after discharge, they received ready-to-use therapeutic food (RUTF). This increased the mean weight-for-height z-score (WHZ) from −4.27 to −1.75 SD. Blood samples were obtained at presentation, after 2 weeks of inpatient therapy, and after 4 to 10 weeks of RUTF. Plasma samples were analyzed by tandem mass spectrometry and microassays. Results At presentation there were high levels of non-esterified fatty acids (NEFA), ketones, and even-chain acylcarnitines, indicating active lipolysis and fatty acid oxidation. In contrast, albumin, amino acids, and C3 carnitine, a by-product of branched-chain amino acids, were low. Levels of insulin, insulin-like growth factor 1 (IGF-1), adiponectin, and leptin were low, while levels of ghrelin, growth hormone, cortisol, interleukin 6 (IL-6), peptide YY (PYY), and glucagon-like peptide 1 (GLP-1) were high. The metabolic and hormonal changes were reversed by formula feeding and RUTF. Biomarkers associated with mortality included HIV, WHZ, and mid-upper-arm circumference (MUAC); the biochemical factor associated most strongly with mortality was low leptin, a marker of adipose reserve and modulator of immune function. Conclusions Low leptin predicts mortality in edematous and nonedematous patients with SAM. Leptin assays might be used to identify malnourished children at highest risk for death.
Adverse reactions in cattle to a capripox vaccine

Capripox vaccine (strain 0240) caused severe generalised skin reactions in vaccinated dairy cattle in two herds, whereas beef cattle did not develop reactions. All the reacting animals developed lumpy skin disease-like lesions. The incidence of skin lesions in first-lactation cows in herd A was 22.9 per cent and in herd B 29.3 per cent, mainly in the post-calving period. In older cows, the incidence was 10 per cent in herd A and 12.4 per cent in herd B. In herd B the high-yielding lactating cows were the most severely affected. There was a decrease of 3.5 per cent in milk production in each herd over a period of 12 days, and six first calving animals (3.5 per cent) and six cows (1.5 per cent) were slaughtered. A capripox virus was isolated from the animals with severe lesions, and was also demonstrated by electron microscopy. The histopathological lesions were similar to those of lumpy skin disease. The extent of the lesions appeared to be stress-related and, to a lesser degree, correlated with age and breed.
Practicing autonomously: a comparison of nurses.

Forty-five subjects including community health nurses with baccalaureate nursing degrees, senior-level generic nursing students, and registered nurses in a baccalaureate nursing program were compared on age, years of employment in nursing, and three variables of professional autonomy: nurses' rights and responsibilities, the nurse-patient relationship, and nurses' role in health care delivery. It was predicted that nurses from baccalaureate programs and those practicing in community health nursing would perceive themselves as more autonomous and that age and years of employment in nursing would not appreciably alter perceptions of autonomy. An analysis of variance confirmed the initial prediction at the 0.01 level of significance or better for nurses' rights and responsibilities and their role in health care delivery. A significant negative correlation was obtained between age and nurses' rights and responsibilities for the community health nurses; a significant positive correlation was obtained between years of work experience and nurses' rights and responsibilities for only the registered nurses. This study is perceived as an initial step in a lengthy process aimed at identifying factors that influence nurses' perceptions about professional autonomy.
Ancient archives: the edict of Alexander to Priene, a reappraisal

‘The historical value of an object depends not so much on the nature of the object as on its associations, which only scientific excavation can detect. ’ The full significance of an inscription may equally rely on knowledge of its archaeological context. In practice, however, users of inscriptions often neglect this aspect. The standard commentaries, new and old, on Alexander's famous ‘edict to Priene’ (hereafter ‘AE’) tend to ignore the physical context of the inscription (I.Priene I) and to treat the text as an isolated or one-off document. Consequently no-one reading Dittenberger, Tod or now Heisserer would learn that it is one of a series of public inscriptions with a consistent theme belonging to an ‘archive’ of connected texts. The inscription is not discussed as one of a group of documents, its monumental setting is largely ignored and the rich corpus of Prienian inscriptions is not exploited fully as a control and source for the historical background of the AE. It is the purpose of this article to try to show that the AE cannot be properly studied in this archaeological limbo. ‘The associations’ of the AE are vital. They provide a new perspective from which to study the text.
Evaluation of six single nucleotide polymorphisms for bovine traceability in the context of the argentine-chinese beef trade

Genetic traceability refers to methods associated with the identification of animals and their products through DNA characterization of individuals, breeds or species. To trace breeds, it is necessary to define the breed groups to analyze, and the most appropriate molecular marker set. The selection of genetic markers depends on the gene frequency distribution, the genetic distance among breeds and the presence of private alleles. In this study, we assessed six single nucleotide polymorphisms (SNPs) located in the DGAT1, TG, LEP, GH, FABP4 and GnRHR genes, as potential genetic markers to be included into a panel for genetic traceability for the identification of breed origin associated with the bovine beef trade. The results of the genetic characterization of four of the main Chinese cattle populations and of the principal breeds raised in Argentina and in the world (five Bos taurus and two B. indicus) suggest that these SNP markers can be successfully used as a part of an effective traceability system for the identification of cattle breed origin in the context of the Chinese meat imports, and in particular in the Argentine-Chinese beef trade.
The somatotopic organization of area 2 in macaque monkeys

Area 2 is a traditional architectonic subdivision of anterior parietal cortex in macaque monkeys, but its overall somatotopic organization and responsiveness to different types of somatic stimuli are poorly understood, and there are uncertainties concerning its rostral and caudal extent. The goals of the present study were to define the rostral and caudal borders of area 2 better, and to describe its overall organization and responsiveness. Somatic receptive fields were defined for hundreds of closely spaced microelectrode recording sites in postcentral parietal cortex of individual macaque monkeys anesthetized with ketamine. Electrophysiological and architectonic evidence suggested that a 3–4‐mm‐wide strip of cortex along the caudal border of area 1 includes all or most of area 2. The most lateral explored portion of area 2 adjoined the representation of the face in area 1. Much of this sector of area 2 was activated by cutaneous stimulation of the face, especially the chin, but more caudal parts of the head also were represented there. Medially, an adjacent sector of area 2 represented the hand. Rostrally, in the cortex within 1.5 mm from the area 1 border, the glabrous surfaces of digits 5 through 1 were represented in a mediolateral cortical sequence, and from tip to base in a rostrocaudal sequence, mirroring the organization in the adjacent portion of area 1. More caudally at this mediolateral level of area 2, digit tips and other phalanges were represented for a second time. The pads of the palm and the dorsal surfaces of the hand were represented laterally and medially within the portion of area 2 devoted to the hand. More medially, the wrist, forearm, and arm were represented in a lateromedial cortical sequence in area 2, roughly matching the mediolateral organization within the bordering area 1. However, immediately caudal to the representation of the occiput, neck, and shoulder in area 1, a rostrocaudal strip of cortex extending across area 2 represented the arm and forearm for a second time in area 2. This cutaneously activated strip of cortex extended into area 5, where the proximal portion of the hand was represented. More medially, next to the trunk representation in area 1, area 2 was devoted to the trunk and limbs. Next to the representations of the ankle, leg, and thigh in area 1, area 2 was activated from similar locations on the hindlimb. Most medially in area 2, the glabrous digits 1–5 of the foot were represented in a lateromedial sequence.
Long‐term muscular outcome and predisposing and prognostic factors in juvenile dermatomyositis: A case–control study

To compare muscle strength, physical health, and HLA–DRB1 allele carriage frequencies in patients with longstanding juvenile dermatomyositis (DM) with that of controls, and to determine the presence of and risk factors for muscle weakness and magnetic resonance imaging (MRI)–detected muscle damage in juvenile DM patients.
A Study of Interaction between Product and Service Qualities and Satisfaction

Information system organizations frequently offer complex IT applications and services to its users. These organizations would want the users of these systems to imbue positive “intentions to use” toward the systems. According to the literature, the construct “intention to use” is influenced by the “perceived satisfaction” derived by the particular user when using or consuming a particular product. For complex systems such as non-trivial IT products, user satisfaction is extremely important in terms of use of that particular system. In this paper, we posit that there are two components of “perceived satisfaction”, namely “product subsystem satisfaction” and “service subsystem satisfaction” and that these two components jointly influence the users’ “intention to use”. When users encounter both a product and its service, they are likely to form separate perceptions about product quality and service quality. Product and service qualities would in-turn cause product subsystem satisfaction and service subsystem satisfaction. The satisfaction subsystems independently influence the “intention to use”. We are conducting a field study to confirm the relationships between the quality subsystem, the service subsystem, the intention to use, and the interaction between service and product quality subsystems. The field study is being conducted in a firm which has implemented a company wide ERP system. In this paper, we expect to reveal relationships between the constructs of perceived quality, satisfaction and behavioral intentions in the “service subsystem” and the “product subsystem”. Moreover, the study will also provide evidence to the extent of interaction between the two subsystems.
Regeneration of Aspergillus nidulans protoplasts.

SUMMARY: The process of regeneration of mycelial protoplasts from Aspergillus nidulans wild-type and strain p76 has been investigated. In liquid media two patterns of regeneration were observed. In the first, the protoplasts produced chains of yeast-like cells and eventually the terminal cell produced a hypha. In the second wall ‘shells’ were formed into which the cytoplasm migrated. It is suggested that the mechanism of regeneration reflects the site of origin of the protoplast from the parent hypha.
The shape of the hominoid proximal femur: a geometric morphometric analysis

As part of the hip joint, the proximal femur is an integral locomotor component. Although a link between locomotion and the morphology of some aspects of the proximal femur has been identified, inclusive shapes of this element have not been compared among behaviourally heterogeneous hominoids. Previous analyses have partitioned complex proximal femoral morphology into discrete features (e.g. head, neck, greater trochanter) to facilitate conventional linear measurements. In this study, three‐dimensional geometric morphometrics are used to examine the shape of the proximal femur in hominoids to determine whether femoral shape co‐varies with locomotor category. Fourteen landmarks are recorded on adult femora of Homo, Pan, Gorilla, Pongo and Hylobates. Generalized Procrustes analysis (GPA) is used to adjust for position, orientation and scale among landmark configurations. Principal components analysis is used to collapse and compare variation in residuals from GPA, and thin‐plate spline analysis is used to visualize shape change among taxa. The results indicate that knucklewalking African apes are similar to one another in femoral shape, whereas the more suspensory Asian apes diverge from the African ape pattern. The shape of the human and orangutan proximal femur converge, a result that is best explained in terms of the distinct requirements for locomotion in each group. These findings suggest that the shape of the proximal femur is brought about primarily by locomotor behaviour.
Field Experiments, Social Networks, and Development

The study of social networks has become an important part of the economics tool kit. Modeling agents as independent actors misses the countless ways in which actions are shaped by the traits, beliefs and decisions of their peers. Similarly, in order to measure general equilibrium effects of a policy intervention, it is crucial to understand not only how a beneficiary is affected directly, but how an intervention spills over to others in the agent’s community. Measuring spillovers and peer effects is notoriously difficult, especially using observational data (Manski (1993)). Social relationships are often endogenous, and connected individuals are likely to have similar characteristics and experience common shocks. Thus, it should be no surprise that following the rise of experimental methods in microeconomics, many researchers have also begun to use experiments to tackle questions involving social networks and to revisit insights from foundational non-experimental papers.1 The way in which networks have been studied using experiments has evolved as the literature has matured. One of the simplest ways to measure spillovers is to use the spatial variation induced from randomization to measure geographical spillovers. Another common technique is to record baseline membership in groups such as kinship, caste, ethnicity, classroom, or borrowing groups and to again use variation in treatment status or group-level treatment intensity to identify social effects. A more recent, but growing subset of the literature has begun to move away from mutually exclusive and symmetric group memberships towards incorporating more complex network structures and even global network (i.e., graphor communitylevel) characteristics. Usage of network data allows researchers to ask three key questions. First, how does the embedding of individuals in a social network shape
Fulminant hepatic failure: to transplant or not to transplant.

Despite progress in intensive care regimens and the introduction of various hepatic support procedures, the survival rate for fulminant hepatic failure remained around 20%. In the past few years, orthotopic liver transplantation has increased the survival rate to more than 50% and thus is generally considered the treatment of choice. However, since about 20% of the patients on standard therapy recover spontaneously, not all patients presenting with fulminant hepatic failure should undergo transplantation immediately. Therefore attempts should be made to identify the patients with "potentially reversible" liver disease in an early phase. In this article strategies for deciding which therapy fits the individual patient are proposed. The decision "to transplant or not to transplant" should be based on residual functioning liver-cell mass (e.g. factor V is less or greater than 15%), the presence or absence of systemic complications such as lactic acidosis and renal failure and the aetiology of the liver disease (e.g. reversible causes such as viral hepatitis B and irreversible causes such as Wilson's disease). A flow diagram has been constructed.
Comparison of alemtuzumab vs. antithymocyte globulin induction therapy in primary non‐sensitized renal transplant patients treated with rapid steroid withdrawal

Alemtuzumab and rabbit antithymocyte globulin (rATG) are commonly used for induction therapy in renal transplantation. This retrospective, single‐center, cohort study evaluated cumulative incidence of one‐yr biopsy‐proven acute rejection (BPAR) among 200 consecutive primary non‐sensitized kidney transplant recipients who received either alemtuzumab (n = 100) or rATG (n = 100) induction followed by rapid steroid taper, tacrolimus, and mycophenolate mofetil. Protocol biopsies, plasma and urine BK virus PCR, serum creatinine and iothalamate glomerular filtration rate (iGFR), were obtained at 1, 4, and 12 months from transplantation. The one‐yr BPAR rates were similar between the alemtuzumab and rATG groups; however, rejection Banff IA and higher was more common in the alemtuzumab arm (18% vs. 5%, p = 0.047). After adjusting for confounding variables, alemtuzumab was still associated with Banff IA and higher rejection (adjusted OR: 3.7, CI: 1.2–10.5, p = 0.02). Despite similar rates of BK viremia, more patients in the alemtuzumab arm developed BK nephropathy (16% vs. 3%, p = 0.046). One‐year iGFR (53.4 ± 20.2 vs. 71.9 ± 27.2 mL/min/1.73 m2, p = 0.002) and three‐yr graft survival (89.5% vs. 95%, p = 0.05) were lower in the alemtuzumab group. In low immunological risk kidney transplant recipients on steroid‐free immunosuppression, alemtuzumab was associated with more severe rejection and BK nephropathy compared to rATG.
Testing the phenotype‐linked fertility hypothesis in the presence and absence of inbreeding

The phenotype‐linked fertility hypothesis suggests that females can judge male fertility by inspecting male phenotypic traits. This is because male sexually selected traits might correlate with sperm quality if both are sensitive to factors that influence male condition. A recent meta‐analysis found little support for this hypothesis, suggesting little or no shared condition dependence. However, we recently reported that in captive zebra finches (Taeniopygia guttata) inbreeding had detrimental effects both on phenotypic traits and on measures of sperm quality, implying that variation in inbreeding could induce positive covariance between indicator traits and sperm quality. Therefore, we here assess empirically the average strength of correlations between phenotypic traits (courtship rate, beak colour, tarsus length) and measures of sperm quality (proportion of functional sperm, sperm velocity, sperm length) in populations of only outbred individuals and in mixed populations consisting of inbreds (F = 0.25) and outbreds (F = 0). As expected, phenotype sperm‐trait correlations were stronger when the population contained a mix of inbred and outbred individuals. We also found unexpected heterogeneity between our two study populations, with correlations being considerably stronger in a domesticated population than in a recently wild‐derived population. Correlations ranged from essentially zero among outbred‐only wild‐derived birds (mean Fisher's Zr ± SE = 0.03 ± 0.10) to moderately strong among domesticated birds of mixed inbreeding status (Zr ± SE = 0.38 ± 0.08). Our results suggest that, under some conditions, the phenotype‐linked fertility hypothesis might apply.