Miracle-dz/UniFAR-FTUs huggingface dataset:
A Comparison between a Retrograde Interference Screw, Suture Button, and Combined Fixation on the Tibial Side in an All-Inside Anterior Cruciate Ligament Reconstruction

Background Effective soft tissue graft fixation to the tibial tunnel in all-inside anterior cruciate ligament reconstructions has been reported to be a problem and may lead to retrograde pullout at ultimate load testing. Hypothesis A combined retrograde bioabsorbable screw and cortical-cancellous suture button suspension apparatus would gain stiffness from the button and strength from the screw, thus providing for a larger pullout ultimate load, yield load, and stiffness when compared with either fixation alone in an all-inside anterior cruciate ligament reconstruction. Study Design Controlled laboratory study. Methods Eighteen porcine tibias (average bone mineral density of 1.46, measured by dual-energy x-ray absorptiometry scan) and 18 bovine extensor tendon allografts were divided into 3 groups retrograde bioabsorbable screw fixation, cortical-cancellous suture button suspension apparatus fixation, and combined fixation in the tibia, with 6 specimens per group. They were biomechanically tested with cyclic (500 cycles, 50-250 N, 1 Hz) and load-to-failure (20 mm/min) parameters. Results During cyclic testing, the retrograde screw—only group had a larger cyclic displacement (2.98 ± 2.28 mm) than the suture button with retrograde screw combination group (1.40 ± 0.34 mm). The combination fixation group also produced a higher cyclic stiffness (161.93 ± 61.81 N/mm) than the retrograde screw—only group (91.59 ± 43.26 N/mm). In load-to-failure testing, the retrograde screw with suture button combination group withstood significantly higher initial failure forces (873.87 ± 148.74 N) than the retrograde screw—only (558.44 ± 126.33 N) and suture button—only (121.76 ± 40.57 N) groups. Additionally, ultimate loads were also significantly higher for the combination group (1027 ± 157.11 N) than either the retrograde screw group (679.00 ± 109.44 N) or the suture button group (161.00 ± 29.27 N). The retrograde screw with suture button combination group showed significantly higher pullout stiffness (152.50 ± 46.37 N/mm) than either the retrograde screw—only group (78.31 ± 12.85 N/mm) or the suture button—only group (25.79 ± 9.30 N/mm). Conclusion Soft tissue grafts fixed with a combination of a retrograde screw and a suture button were able to withstand higher initial failure and ultimate failure loads and were also stiffer than grafts fixed with either a retrograde screw or a suture button alone. Clinical Relevance These findings may prove useful in providing additional stability when using an all-inside technique in a difficult case, or in a patient with poor bone stock, and may also be useful as an alternative to more commonly used tibial tunnel soft tissue fixation techniques.
Family factors in adolescent problematic Internet gaming: A systematic review

Background and aims Familial influences are known to affect the likelihood of an adolescent becoming a problem gamer. This systematic review examined some of the key findings in empirical research on family factors related to adolescent problem gaming. Methods A total of 14 studies in the past decade were evaluated. Family-related variables included: (a) parent status (e.g., socioeconomic status and mental health), (b) parent–child relationship (e.g., warmth, conflict, and abuse), (c) parental influence on gaming (e.g., supervision of gaming, modeling, and attitudes toward gaming), and (d) family environment (e.g., household composition). Results The majority of studies have focused on parent–child relationships, reporting that poorer quality relationships are associated with increased severity of problem gaming. The paternal relationship may be protective against problem gaming; therefore, prevention programs should leverage the support of cooperative fathers. Discussion The intergenerational effects of problem gaming require further attention, in light of adult gamers raising their children in a gaming-centric environment. Research has been limited by a reliance on adolescent self-report to understand family dynamics, without gathering corroborating information from parents and other family members. The very high rates of problem gaming (>10%) reported in general population samples raise concerns about the validity of current screening tools. Conclusions Interventions for adolescents may be more effective in some cases if they can address familial influences on problem gaming with the active co-participation of parents, rather than enrolling vulnerable adolescents in individual-based training or temporarily isolating adolescents from the family system.
A Highly Specific and Discriminatory FISH Assay for Distinguishing Between Benign and Malignant Melanocytic Neoplasms

The diagnosis of certain melanocytic proliferations remains one of the most challenging areas in pathology. In recent times, fluorescence in situ hybridization (FISH) has emerged as a promising diagnostic aid to conventional microscopy. We previously showed that a 4-probe FISH assay targeting 6p25 (RREB1), 6q23 (MYB), Cep6 (centromere 6), and 11q13 (CCND1) could discriminate between histologically unequivocal melanomas and benign nevi with a sensitivity of 86.7% and specificity of 95.4%. However, the sensitivity of the assay is approximately 70% in melanomas with spitzoid morphology. Furthermore, differentiating true gains from tetraploidy may cause difficulties in interpretation by inexperienced examiners. Here we refine the current probe set to better target spitzoid melanomas and more easily distinguish cells with imbalanced copy number aberrations from tetraploid cells. Using FISH data from 3 training sets of 322 tumors, including 152 melanomas and 170 nevi, we identified 9p21, 6p25, 11q13, and 8q24 as a probe set with improved discriminatory power in differentiating melanomas from nevi. In a validation set of 51 melanomas and 51 nevi this probe set had a sensitivity of 94% and specificity of 98%, compared with the original probe set that had a sensitivity of 75% and specificity of 96% in the same validation cohort. We propose that by incorporating 9p21 into the 4-probe FISH assay, with a new diagnostic algorithm, this new probe set would have improved discriminatory power in melanocytic neoplasms and improved sensitivity for detecting spitzoid melanomas, as demonstrated by our previous studies.
Aggregation of Downside Risk and Portfolio Selection

This paper studies the aggregation of a downside risk measure introduced by Fishburn (1977). Properties of aggregated downside risk are examined and compared to classical risk measures such as standard deviation and value-at-risk. The notion of downside-efficient portfolios that maximize the expected payoff given a prescribed upper bound for downside risk is introduced. A separation theorem for the existence and uniqueness of portfolios that maximize the trade-off between downside risk and return is established.
1α,25‐(OH)2D3 acts in the early phase of osteoblast differentiation to enhance mineralization via accelerated production of mature matrix vesicles

1α,25‐dihydroxyitamin D3 (1,25D3) deficiency leads to impaired bone mineralization. We used the human pre‐osteoblastic cell line SV‐HFO, which forms within 19 days of culture an extracellular matrix that starts to mineralize around day 12, to examine the mechanism by which 1,25D3 regulates osteoblasts and directly stimulates mineralization. Time phase studies showed that 1,25D3 treatment prior to the onset of mineralization, rather than during mineralization led to accelerated and enhanced mineralization. This is supported by the observation of unaltered stimulation by 1,25D3 even when osteoblasts were devitalized just prior to onset of mineralization and after 1,25D3 treatment. Gene Chip expression profiling identified the pre‐mineralization and mineralization phase as two strongly distinctive transcriptional periods with only 0.6% overlap of genes regulated by 1,25D3. In neither phase 1,25D3 significantly altered expression of extracellular matrix genes. 1,25D3 significantly accelerated the production of mature matrix vesicles (MVs) in the pre‐mineralization. Duration rather than timing determined the extent of the 1,25D3 effect. We propose the concept that besides indirect effects via intestinal calcium uptake 1,25D3 directly accelerates osteoblast‐mediated mineralization via increased production of mature MVs in the period prior to mineralization. The accelerated deposition of mature MVs leads to an earlier onset and higher rate of mineralization. These effects are independent of changes in extracellular matrix protein composition. These data on 1,25D3, mineralization, and MV biology add new insights into the role of 1,25D3 in bone metabolism and emphasize the importance of MVs in bone and maintaining bone health and strength by optimal mineralization status. J. Cell. Physiol. 225: 593–600, 2010. © 2010 Wiley‐Liss, Inc.
Perception of dentine hypersensitivity and its management by a group of Nigerian dentists.

BACKGROUND Dentists need to be aware of the management of dentine sensitivity in view of its high prevalence. OBJECTIVE The study is to determine by questionnaire the perception of dentine hypersensitivity (DH) and its management by Nigerian Dentists. METHOD A structured questionnaire was used to collect data from 176 Nigerian Dentists who attended professional dental workshops in Lagos, Ife and Jos, Nigeria. RESULTS The majority (73.3%) of the responding dentists claimed to see patients with DH. Nearly half (45.1%) of the dentists mentioned cold as the commonest stimulus evoking pain in DH while 56.8% could correctly identified the hydrodynamic theory as the commonest theory of tooth hypersensitivity. Multifactorial aetiology identified as causing DH included tooth wear lesions, periodontal causes and bruxism. Treatment options suggested varies but non-invasive was mentioned more than the invasive techniques. Sensodyne toothpaste was the commonest desensitising paste mentioned. The knowledge of Nigerian Dentists was found to be associated with the specialty of the practitioners (p = 0.0004). CONCLUSION Dental Practitioners, especially the General Dental Practitioners should be enthusiastic in updating their knowledge of DH and the management. Prevention of DH by the Patients and the Dentists should be emphasised.
Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1(−/−) mice

Agonist-induced Ca2+ entry via store-operated Ca2+ (SOC) channels is suggested to regulate a wide variety of cellular functions, including salivary gland fluid secretion. However, the molecular components of these channels and their physiological function(s) are largely unknown. Here we report that attenuation of SOC current underlies salivary gland dysfunction in mice lacking transient receptor potential 1 (TRPC1). Neurotransmitter-regulated salivary gland fluid secretion in TRPC1-deficient TRPC1(−/−) mice was severely decreased (by 70%). Further, agonist- and thapsigargin-stimulated SOC channel activity was significantly reduced in salivary gland acinar cells isolated from TRPC1(−/−) mice. Deletion of TRPC1 also eliminated sustained Ca2+-dependent potassium channel activity, which depends on Ca2+ entry and is required for fluid secretion. Expression of key proteins involved in fluid secretion and Ca2+ signaling, including STIM1 and other TRPC channels, was not altered. Together, these data demonstrate that reduced SOC entry accounts for the severe loss of salivary gland fluid secretion in TRPC1(−/−) mice. Thus, TRPC1 is a critical component of the SOC channel in salivary gland acinar cells and is essential for neurotransmitter-regulation of fluid secretion.
A Comparison of Mental Health of Multiple Sclerosis Patients with Silver/Mercury Dental Fillings and Those with Fillings Removed

In this study was compared the mental health status of 47 multiple sclerosis patients with silver/mercury tooth fillings (amalgams) to that of 50 patients with their fillings removed. On the Beck Depression Inventory the multiple sclerosis subjects with amalgams suffered significantly more depression while their scores on the State-Trait Anger Expression Inventory indicated the former group also exhibited significantly more anger. On the SCL-90 Revised, subjects with amalgam fillings had significantly more symptoms of depression, hostility, psychotism, and were more obsessive-compulsive than the patients with such fillings removed. On a questionnaire containing 18 mental health symptoms multiple sclerosis subjects with amalgam fillings reported a history of 43% more symptoms than those without amalgam fillings over the past 12 months. These data suggested that the poorer mental health status exhibited by multiple sclerosis subjects with dental amalgam fillings may be associated with mercury toxicity from the amalgam.
Soil Salinity Mapping by Multiscale Remote Sensing in Mesopotamia, Iraq

Soil salinity has become one of the major problems affecting crop production and food security in Mesopotamia, Iraq. There is a pressing need to quantify and map the spatial extent and distribution of salinity in the country in order to provide relevant references for the central and local governments to plan sustainable land use and agricultural development. The aim of this study was to conduct such quantification and mapping in Mesopotamia using an integrated, multiscale modeling approach that relies on remote sensing. A multiyear, multiresolution, and multisensor dataset composed of mainly Landsat ETM+ and MODIS data of the period 2009-2012 was used. Results show that the local-scale salinity models developed from pilot sites with vegetated and nonvegetated areas can reliably predict salinity. Salinity maps produced by these models have a high accuracy of about 82.5-83.3% against the ground measurements. Regional salinity models developed using integrated samples from all pilot sites could predict soil salinity with an accuracy of 80% based on comparison to regional measurements along two transects. It is hence concluded that the multiscale models are reasonably reliable for assessment of soil salinity at local and regional scales. The methodology proposed in this paper can minimize problems induced by crop rotation, fallowing, and soil moisture content, and has clear advantages over other mapping approaches. Further testing is needed while extending the mapping approaches and models to other salinity-affected environments.
The unintended consequence of Financial Fair Play

Purpose The purpose of this paper is to examine competitive balance in European football leagues before and after the inception of Financial Fair Play (FFP) regulations by Union of European Football Associations in 2011, designed to bring about financial stability and improve competitive balance in the European game. Design/methodology/approach The research focuses on the top division football leagues in England (English Premier League), Germany (Bundesliga), France (Ligue 1), Italy (Serie A) and Spain (La Liga). The paper is organised into two distinct time periods: pre-FFP, comprising the six seasons between 2005/2006 and 2010/2011; and post-FFP, comprising the six seasons between 2011/2012 and 2016/2017. The paper uses recognised measures of concentration and dominance to measure competitive balance. Findings The results show a statistically significant decline in competitive balance post-FFP for leagues in Spain, Germany and France but not for England and Italy. Furthermore, the results report significantly higher levels of concentration and dominance by a select number of clubs in Germany. Originality/value The paper is one of the first to analyse competitive balance in this way both pre- and post-FFP. Whilst the paper cannot demonstrate a causal link between FFP and competitive balance, there are strong indications that competitive balance has been adversely affected (for some leagues) since the regulations have been imposed. To that end, the paper argues that FFP has had “unintended consequences” in respect of competitive balance.
Conditions that induce biofilm production by Ornithobacterium rhinotracheale

Ornithobacterium rhinotracheale (ORT) is a Gram-negative bacillus that causes respiratory disease in birds, and directly affects the poultry industry. The mechanisms behind these infections are not completely known. Currently, its capacity to form biofilms on inert surfaces has been reported; however, the conditions for biofilm development have not been described yet. The present work was aimed at identifying the conditions that enhance in vitro biofilm formation and development by ORT. For this, serovars A-E were analysed to assess their ability to induce biofilm development on 96-well flat-bottom polystyrene microtitre plates under diverse conditions: temperature, incubation time, and CO2 concentration. The results obtained showed not only that all serovars have the ability to produce in vitro biofilms, but also that the optimal conditions for biofilm density were 40°C after 72 h at an elevated CO2 concentration. In conclusion, ORT biofilm formation depends on the environmental conditions and may contribute to the persistence of this microorganism.
Control of a Quadrotor With Reinforcement Learning

In this letter, we present a method to control a quadrotor with a neural network trained using reinforcement learning techniques. With reinforcement learning, a common network can be trained to directly map state to actuator command making any predefined control structure obsolete for training. Moreover, we present a new learning algorithm that differs from the existing ones in certain aspects. Our algorithm is conservative but stable for complicated tasks. We found that it is more applicable to controlling a quadrotor than existing algorithms. We demonstrate the performance of the trained policy both in simulation and with a real quadrotor. Experiments show that our policy network can react to step response relatively accurately. With the same policy, we also demonstrate that we can stabilize the quadrotor in the air even under very harsh initialization (manually throwing it upside-down in the air with an initial velocity of 5 m/s). Computation time of evaluating the policy is only 7 $\mu$s per time step, which is two orders of magnitude less than common trajectory optimization algorithms with an approximated model.
Melanoma, Parkinson's disease and levodopa: causal or spurious link? A review of the literature

Since the early 1970s, a number of case reports have suggested that levodopa therapy for Parkinson's disease increases the risk of cutaneous malignant melanoma. As yet, no formal epidemiological study has been conducted to verify this hypothesis. To elucidate the relationship between levodopa and the risk of cutaneous malignant melanoma, a systematic literature search using computerized bibliographic databases was done. This review presents the case history evidence for and against the hypothesis of a causal association, and explores possible epidemiological, genetic, social, biochemical and toxicological factors that may increase the risk of melanoma in Parkinson's disease patients. All the case reports in the literature were considered. We concluded that (1) there is no epidemiological or experimental evidence of a causal role of levodopa in increasing the risk of melanoma incidence or progression; (2) there is good evidence of an excess risk of melanoma in patients with Parkinson's disease; (3) there is good evidence of a protective effect of tobacco smoking on the risk for Parkinson's disease; (4) there is good evidence of positive correlation between social class and melanoma risk; (5) the relationship between the risk of Parkinson's disease and the risk of melanoma may be due to a common genetic profile or it can be attributed to a confounding role of social class, associated with both melanoma and Parkinson's disease possibly through an inverse relationship with tobacco smoking.
Coping with Ageing: A Dynamic Approach to Quantify the Impact of Alternative Policy Options on Future Labour Supply in OECD Countries

In the face of the substantial ageing of population expected to occur in OECD countries over coming decades, policies that boost labour-force participation attract considerable interest. There remain large cross-country divergences in participation rates that are largely accounted for by differences in participation of specific groups, in particular prime-age women, older workers and also youth. This suggests that policies targeting these groups could have important effects. The aim of this paper is to examine whether the potential impact of several policy reforms is able to attenuate or to offset the adverse trend in aggregate participation rates that would otherwise occur because of ageing population. It uses a simple dynamic modelling framework that generates longer-term projections of participation rates and labour supplies in OECD countries and alternative scenarios of policy reforms. The main outcome of this analysis is that the combined effect of possible reforms targeting . Faire face au vieillissement : Une approche dynamique pour mesurer l'impact d'alternatives politiques sur l'offre future de travail dans les pays de l'OCDE Les pays de l’OCDE sont confrontes a un vieillissement important de leur population au cours des decades a venir et ceci explique le regain d’interet considerable pour les politiques susceptibles de stimuler la participation au marche du travail. Il subsiste des differences importantes de participation entre les pays de l’OCDE qui s’expliquent en grande partie par des differences de participation de groupes specifiques, en particulier les femmes dans la force de l’âge, les travailleurs âges et les jeunes. Ces differences suggerent qu’il reste une marge de manoeuvre importante pour des reformes de politique economique visant ces groupes. Le but de ce papier est d’examiner si l’impact potentiel d’un certain nombre de reformes est susceptible d’attenuer, voire de compenser, la tendance future a la diminution des taux de participation agreges telle qu’elle resulterait du vieillissement de la population. Cette analyse utilise un modele dynamique simple qui genere des previsions a long .
Long-term prognosis of isolated significant tricuspid regurgitation.

BACKGROUND The prognostic implications and surgical benefit of isolated significant tricuspid regurgitation (TR) and prognostic factors in patients with TR were investigated. METHODS AND RESULTS In 870 consecutive patients with significant isolated TR, all-cause mortality was analyzed over 4.9+/-2.9 years. It was found that the survival rate tended to be higher in the 57 patients who underwent tricuspid valve (TV) surgery than the 813 patients who did not by using propensity-score matching (P=0.068), although it was not significant. Of the 813 patients that did not undergo TV surgery, the 5-year survival rate was 74%. According to the Cox proportional hazards model, the initial TR jet area (hazard ratio [HR], 1.044; 95% confidence interval [CI], 1.016-1.073), pulmonary artery systolic pressure (HR, 1.024; 95%CI, 1.017-1.032) and presence of right ventricular (RV) dysfunction (HR, 2.256; 95% CI, 1.329-3.828) were predictors of mortality independent of patient age and presence of diabetes mellitus and renal failure in medically managed patients. CONCLUSIONS In patients with isolated significant TR, there was a tendency, although not significant, towards a higher survival rate after TV surgery. The severity of TR and pulmonary hypertension, and the presence of RV dysfunction are independent prognostic factors in medically managed patients. Further prospective randomized studies are necessary to demonstrate the benefit of TV surgery in these poor prognostic populations.