Miracle-dz/UniFAR-FTUs huggingface dataset:
Biopsychological, affective and cognitive responses to acute physical activity.

BACKGROUND To investigate, based on biopsychological arousal theory, the influence of physical activity intensity on biopsychological, affective and cognitive function. METHODS DESIGN Repeated measures experiment involving one control and three treatment conditions. SETTING Controlled laboratory environment. PARTICIPANTS Twenty-one (of 27 volunteers) non-contraindicated females (55-65 years) recruited from general community and university populations completed the study. INTERVENTIONS Data collection proceeded in four counterbalanced test-sessions including control (zero resistance), light (45%VO2max), moderate (60%VO2max), and high intensity (75%VO2max) cycle ergometer interventions. In all test sessions participants cycled at 25 W for 2 min (warm-up), followed by 10 min at the allocated intensity, and then 2 min at 25 W (cool-down). Blood pressure, heart rate and RPE were determined during test sessions. MEASURES Energetic arousal (EA), tense arousal (TA), single dimension affect, and cognitive (reaction time-RT) responses were compared following physical activity. RESULTS There was no significant difference in EA, TA, affect, or RT following zero resistance and light and moderate intensity physical activity or between light and moderate intensity physical activity. High intensity physical activity resulted in significantly lower levels of EA than light intensity physical activity, significantly higher levels of TA than zero resistance and light intensity physical activity, and significantly more negative levels of affect than either light or moderate intensity physical activity. There were no significant differences in reaction time between high intensity physical activity and any of the other intensities. CONCLUSIONS There was partial support for the efficacy of biopsychological arousal theory in explaining the biopsychological and affective outcomes of physical activity, but no support for the influence of physical activity on cognitive function.
Multiple sclerosis susceptibility and the X chromosome

Multiple sclerosis (MS) is a chronic autoimmune complex trait with strong evidence for a genetic component. A female gender bias is clear but unexplained and a maternal parent-of-origin effect has been described. X-linked transmission of susceptibility has been previously proposed, based on pedigree, association and linkage studies. We genotyped 726 relative pairs including 552 affected sib-pairs for 22 X-chromosome microsatellite markers and a novel dataset of 195 aunt-uncle/niece-nephew (AUNN) affected pairs for 18 markers. Parent-of-origin effects were explored by dividing AUNN families into likely maternal and paternal trait transmission. For the sib-pair dataset we were able to establish exclusion at a λ s = 1.9 for all markers using an exclusion threshold of LOD ≤—2. Similarly for the AUNN dataset, we established exclusion at λAV = 1.9. For the combined dataset we estimate exclusion of λ = 1.6. We did not identify significant linkage in either the sib-pairs or the AUNN dataset nor when datasets were stratified for the presence/absence of the HLA-DRB1*15 allele or for paternal or maternal transmission. This comprehensive scrutiny of the X-chromosome suggests that it is unlikely to harbour an independent susceptibility locus or one which interacts with the HLA. Complex interactions including epigenetic ones, and masking by balanced polymorphisms are mechanisms not excluded by the approach taken. Multiple Sclerosis 2007; 13 : 856—864. http://msj.sagepub. com
New Product Innovation in Established Companies: Associations with Industry and Strategy Variables

As concern over the competitiveness of the U.S. persists, attention is given to understanding the factors associated with product innovation. To date, the bulk of research has focused on the organizational variables (e.g., formal structure) that spur or impede a company's new product development and introduction efforts. The present study extends the literature by examining the relationship of a firm's industry characteristics and the content of its competitive strategy, and the number and timing of new product introductions. Data from 134 established manufacturing companies (i.e., firms that have been in existence for more than eight years) show that a firm's Industry characteristics and competitive strategy explain a significant portion of variance in both the number and early introduction of new products. The implications of the results for managerial action and future research are also discussed.
High-Accuracy Ultrasonic Rangefinders via pMUTs Arrays Using Multi-Frequency Continuous Waves

This paper presents a high accuracy air-coupled reflective ultrasonic rangefinder based on piezoelectric micromachined ultrasonic transducers (pMUTs) using multi-frequency continuous waves (MFCWs). Two pieces of <inline-formula> <tex-math notation="LaTeX">$5~times~5$ </tex-math></inline-formula> AlN pMUTs arrays at the resonant frequency of 492 kHz are employed to transmit and receive ultrasonic signals, respectively. The MFCW method, where the distance information is calculated from the phase difference, can cancel out the random noise in numerous repeating periods. Therefore, high-accuracy range measurement is achieved. The <inline-formula> <tex-math notation="LaTeX">$3\sigma $ </tex-math></inline-formula> accuracy of the short distance measurement (< 100 mm) is 0.0711 mm with 0.096 mm/° first-order resolution and <inline-formula> <tex-math notation="LaTeX">$1.934~\mu \text{m}$ </tex-math></inline-formula>/° second-order resolution. For long distance measurement (100–300 mm), the <inline-formula> <tex-math notation="LaTeX">$3\sigma $ </tex-math></inline-formula> accuracy is 1.8208 mm with 0.481 mm/° first-order resolution and <inline-formula> <tex-math notation="LaTeX">$1.954~\mu \text{m}$ </tex-math></inline-formula>/° second-order resolution. The MFCW-based rangefinder using pMUTs is a good candidate for short distance measurement with high accuracy. [2018-0267]
Bivalirudin for acute coronary syndromes: premises, promises and doubts

Summary Bivalirudin is a valuable anticoagulant option in patients with acute coronary syndromes (ACS) undergoing percutaneous coronary intervention. Advantages over heparin as a parenteral anticoagulant include more predictable pharmacokinetics and pharmacodynamics, shorter half-life, no need for cofactors, some degree of antiplatelet effect, and the ability to inhibit clot-bound thrombin. Clinical evidence supporting the use of bivalirudin over heparin in current ACS guidelines, however, derives mostly from early randomised trials that may no longer reflect current management patterns, now including the use of oral antiplatelet agents more potent than clopidogrel (i.e. prasugrel or ticagrelor) and a broader implementation of strategies to reduce bleeding (i.e. radial access for percutaneous coronary intervention, and use of glycoprotein IIb/IIIa inhibitors only in bailout situations). Defining the fine balance between bivalirudin efficacy and safety over heparins in the context of other antithrombotic treatments remains a challenge in clinical practice, particularly in a fast-evolving scenario, such as ACS, where numerous new trials have been presented in very recent times. Here we provide an up-to-date overview of the evidence on the use of bivalirudin in ACS, with focus on new data, open issues, and future directions.
Polarizabilities of platonic solids

This article presents results of a numerical effort to determine the dielectric polarizabilities of the five regular polyhedra: tetrahedron, cube, octahedron, dodecahedron, and icosahedron. The polarizability is calculated by solving a surface integral equation, in which the unknown potential is expanded using third-order basis functions. The resulting polarizabilities are accurate to the order of 10/sup -4/. Approximation formulas are given for the polarizabilities as functions of permittivity. Among other results, it is found that the polarizability of a regular polyhedron correlates more strongly with the number of edges than with the number of faces, vertices, or the solid angle seen from a vertex.
Prognostic and Predictive Relevance of DNAM-1, SOCS6 and CADH-7 Genes on Chromosome 18q in Colorectal Cancer

Purpose: Chromosome 18q deletion has been described as a negative prognostic factor in colorectal cancer (CRC). The relationship between its supposed negative prognostic influence and the inactivation of candidate tumor suppressors deleted in colorectal cancer, Smad2 and Smad4 has not been definitively established. The aim of the present study was to evaluate the genetic status of three novel putative tumor suppressors, Cadh-7, DNAX accessory molecule-1 (Dnam-1) and suppressor of cytokine signaling (Socs6) on chromosome 18q and to correlate molecular results with patient survival and benefit from adjuvant chemotherapy. Experimental Design: One hundred and ninety representative patient samples from a randomized multicenter study of the Swiss Group for Clinical Cancer Research of 5-fluorouracil (5-FU)- based adjuvant chemotherapy were screened for the gene copy status of Cadh-7, Socs6 and Dnam-1 using real-time quantitative PCR assay, and the molecular results were correlated with clinical outcome. Results: Loss of gene copy number was found in 26.8, 37.9 and 54.2% for Cadh-7, Dnam-1 and Socs6, respectively. Only Dnam-1 deletion was an independent negative prognostic factor for the 5-year overall survival (OS) in the untreated group of patients (hazard ratio = 2.44; p = 0.01). On the contrary, loss of Cadh-7 gene copy number was a favourable prognostic factor for disease-free survival (hazard ratio = 0.43; p = 0.03) and OS (hazard ratio = 0.29; p = 0.01) in the untreated control population. Furthermore and most importantly, patients with Dnam-1 deletion who received adjuvant chemotherapy had a significantly lower risk of death compared to untreated patients with Dnam-1 deletion (hazard ratio = 0.51; p = 0.05), whereas those with Dnam-1 retention did not derive any benefit from 5-FU-based treatment (hazard ratio = 1.68; p = 0.16). Conclusions: Loss of Dnam-1 gene copy number and retention of Cadh-7 might be indicators of worse prognosis, and Dnam-1 deletion might predict for a beneficial response to adjuvant 5-FU-based chemotherapy in patients with CRC. The confirmation of our findings in large independent randomized studies is needed.
Psychiatric co-morbidity among male heroin addicts: differences between hospital and incarcerated subjects in Taiwan.

AIMS To examine the differences in psychiatric co-morbidity between hospital and incarcerated groups of heroin addicts in Taiwan. DESIGN Life-time prevalence of DSM-III-R-based coexisting psychiatric disorders, including personality disorders, were surveyed. SETTINGS A psychiatric hospital and two prisons. PARTICIPANTS Two hundred and sixty heroin users who were incarcerated in prisons, and 47 heroin users who voluntarily sought help in a psychiatric hospital were interviewed by board-certified psychiatrists. MEASUREMENTS Using two psychometric instruments, the Psychiatric Diagnostic Assessment (PDA) and the Structured Interview for DSM-III-R Personality Disorders (SIPD-R), psychiatric co-morbidity was assessed. FINDINGS Different life-time rates of coexisting psychiatric disorders among heroin addicts in different settings were found: 83% of hospital subjects and 66% of incarcerated subjects were diagnosed as having at least one coexisting axis I or II disorder. The most prevalent coexisting DSM-III-R defined axis I disorders were additional substance use disorders (alcohol and methamphetamine), while the axis II disorder was antisocial personality disorder. The hospital group had a significantly higher prevalence rate of mood disorder (p < 0.001), paranoid personality disorder (p < 0.05) and antisocial personality disorder (p < 0.001) than the incarcerated group. CONCLUSIONS We suggest that heroin addicts with coexisting psychiatric disorders receive relevant psychiatric treatment. Those with personality disorders, especially the antisocial type, should be considered for specialized therapeutic community programmes instead of incarceration.
A joint analysis of market indexes in credit default swap, volatility and stock markets

ABSTRACT This paper analyses the joint dynamics of the CDS, volatility and stock markets using both VAR and Markov regime-switching VAR models with market index data. It shows that the joint behaviour of the three markets is better characterized by the Markov model with two regimes corresponding to low- and high-volatile market conditions. The relationship between changes in the market indexes under a regime is consistent with theory and persistent; the information transmission process of shocks to the markets is similar for the two regimes with a more important role for CDS shock; and the volatility in the money market is an important determinant of regime-switching. The findings have practical implications, particularly for hedging strategies with market indexes under different market conditions.
Population genetic analysis of microsatellite variation of guppies (Poecilia reticulata) in Trinidad and Tobago: evidence for a dynamic source–sink metapopulation structure, founder events and population bottlenecks

Riverine fish populations are traditionally considered to be highly structured and subject to strong genetic drift. Here, we use microsatellites to analyse the population structure of the guppy (Poecilia reticulata), focussing on the headwater floodplain area of the Caroni drainage in Trinidad. We also analyse the population genetics of guppies in the Northern Drainage in Trinidad, a habitat characterized by rivers flowing directly into the sea, and a small isolated population in Tobago. Upland Caroni populations are highly differentiated and display low levels of genetic diversity. However, we found no evidence to suggest that these upland populations experienced recent population crashes and the populations appear to approach mutation–drift equilibrium. Dominant downstream migration over both short‐ and long‐time frames has a strong impact on the population genetics of lowland Caroni populations. This drainage system could be considered a source–sink metapopulation, with the tributary furthest downstream representing a ‘super sink’, receiving immigrants from rivers upstream in the drainage. Moreover, the effective population size in the lowlands is surprisingly low in comparison with the apparently large census population sizes.
Determinants of mammography use in rural and urban regions of Canada.

INTRODUCTION National guidelines advocate biennial mammography screening for asymptomatic women aged 50-69 years. Unfortunately many women do not abide by such recommendations, and evidence indicates that compliance rates are lower in rural areas. METHODS We estimated logistic regression models using data from the Canadian Community Health Survey for 2002/03 and 2004/05. We identified the extent of regional variation within and between Canadian provinces using a new and more detailed set of rural indicators based on economic zones of influence, after accounting for a range of demographic and socio-economic factors. RESULTS The odds of asymptomatic women aged 50-69 years having undergone mammography during the previous 2 years were significantly lower for those residing in relatively remote and rural areas than for those residing in census metropolitan areas (odds ratio [OR] 0.58, confidence interval [CI] 0.42-0.80). This was also true of women residing in certain other rural areas that had some limited labour market attachment to larger urban areas (OR 0.81, CI 0.70-0.93), but there were no significant differences between smaller and larger urban areas. We also found variation in mammography use among women living in rural and urban areas across provinces. CONCLUSION Mammography use is significantly lower in rural and remote areas, even after a range of other demographic and socio-economic factors are accounted for. One important factor underpinning this result appears to be differences in attitude about the importance of regular mammography screening between women residing in rural and urban areas. Information campaigns raising awareness about the importance of mammography screening should be targeted, in particular, at women residing in rural and remote areas.
Remittances and Household Expenditure in Rural Nigeria

This paper examines the relationship between remittances and household expenditures in rural Nigeria by using the 2004 living standard survey to analyse how the receipt of domestic remittances (from within Nigeria) and foreign remittances (from abroad) affects the marginal spending behaviour of households on various consumption and investment goods. Expenditures were categorized into six namely food, education, housing, health, consumer goods and others. Results show that households receiving remittances spend less at the margin on consumption of food, consumer goods and durables than do households receiving no remittances. The analysis further shows that a large amount of remittance money goes into education. At the margin, households receiving domestic and foreign remittances spend 45 and 58 percent more, respectively, on education than do households with no remittances. Like other studies, this paper finds that remittance-receiving households spend more at the margin on housing.
The Complete Ordering of Information Alternatives for a Class of Portfolio- Selection Models

A well-known result in information economics is that there is no reason to presume decision makers in diverse settings will be unanimous in the selection of an optimal information structure. On its most basic level this negative result follows because different utility functions and/or different actionchoice problems induce rankings of the information alternatives which will not hold uniformly across alternative settings. The only general exception to the above occurs if one deals with costless information and the set of available information alternatives is comprised of increasingly "fine" information structures in the sense of Blackwell and Girshick (1954). As is wellknown, however, the fineness criterion provides only a partial ordering of the set of all possible information structures. Accordingly, without specification of the circumstances of the decision problem and the decision maker's preferences, it becomes essentially meaningless to make assertions about the usefulness of alternative accounting procedures. A further implication is the impossibility of measuring the value and quality of information. Hence, an important question arising in accounting theory is the identification of conditions such that the concept of usefulness will be meaningful within a class of decision problems. That is, what restrictions on a set of decisioninformation contexts, or settings, are required such that any problem in this set will induce identical orderings on the set of available information structures? On the one extreme, if the set of problems contains only one element, then a solution is, of course, always available; on the other extreme, if the
Committee Size in the U. S. Congress

Westefield (1974) asserts that powerful congressional leaders expand the number of committee seats to create sources of leverage with rank-and-file members. We challenge his interpretation and provide a more rigorous test of his theory. A committee-specific examination of committee-size decisions corroborates Shepsle's (1978) findings. However, a speaker-by-speaker analysis confirms our expectation that Shepsle's findings obscure significant differences between recent House speakers. We argue that committee-size decisions of majority party leaders are shaped more by the changing political conditions they face than by their efforts to gain compliance from rank-and-file members.
Fluorescence Correlation Spectroscopy Analysis of Serotonin, Adrenergic, Muscarinic, and Dopamine Receptor Dimerization: The Oligomer Number Puzzle

The issue of G protein–coupled receptor (GPCR) oligomer status has not been resolved. Although many studies have provided evidence in favor of receptor-receptor interactions, there is no consensus as to the exact oligomer size of class A GPCRs. Previous studies have reported monomers, dimers, tetramers, and higher-order oligomers. In the present study, this issue was examined using fluorescence correlation spectroscopy (FCS) with photon counting histogram (PCH) analysis, a sensitive method for monitoring diffusion and oligomer size of plasma membrane proteins. Six different class A GPCRs were selected from the serotonin (5-HT2A), adrenergic (α1b-AR and β2-AR), muscarinic (M1 and M2), and dopamine (D1) receptor families. Each GPCR was C-terminally labeled with green fluorescent protein (GFP) or yellow fluorescent protein (YFP) and expressed in human embryonic kidney 293 cells. FCS provided plasma membrane diffusion coefficients on the order of 7.5 × 10−9 cm2/s. PCH molecular brightness analysis was used to determine the GPCR oligomer size. Known monomeric (CD-86) and dimeric (CD-28) receptors with GFP and YFP tags were used as controls to determine the molecular brightness of monomers and dimers. PCH analysis of fluorescence-tagged GPCRs revealed molecular brightness values that were twice the monomeric controls and similar to the dimeric controls. Reduced χ2 analyses of the PCH data best fit a model for a homogeneous population of homodimers, without tetramers or higher-order oligomers. The homodimer configuration was unaltered by agonist treatment and was stable over a 10-fold range of receptor expression level. The results of this study demonstrate that biogenic amine receptors freely diffusing within the plasma membrane are predominantly homodimers.
Ferredoxin reductase: pharmacogenomic assessment in colorectal cancer.

Ferredoxin reductase (FDXR) is a putative contributor to TP53-mediated apoptosis from 5-fluorouracil chemotherapy through the generation of oxidative stress. With TaqMan real-time quantitative reverse transcription-PCR, this study established a significant difference in FDXR relative RNA expression level between tumor (median, 212.9 units) and normal tissues (median, 113.8 units) from 51 colorectal cancer patients (P < 0.001). Seven single nucleotide polymorphisms (SNPs) in the FDXR gene were discovered, with no significant difference in variant allele frequency between colon tumor and normal tissues (P > 0.05), and the common haplotypes for FDXR were not different between colon tumor and normal samples. No correlation was observed between FDXR genotype and RNA expression implying that the polymorphisms described in this study are not regulating FDXR expression in colon cancer. This genomic characterization provides the foundation for pharmacogenetic analysis of the impact of FDXR on chemotherapy for colorectal cancer.
PENGARUH INVESTMENT OPPORTUNITY SET, TOTAL ASSET TURN OVER DAN SALES GROWTH TERHADAP KEBIJAKAN DIVIDEN

Penelitian ini bertujuan untuk mengetahui pengaruh investment opportunity set, total asset turn over dan sales growth terhadap kebijakan dividen pada sektor industri barang konsumsi di Bursa Efek Indonesia. Populasi dalam penelitian ini adalah seluruh perusahaan yang tergabung dalam sektor industri barang konsumsi di Bursa Efek Indonesia yang berjumlah 37 perusahaan periode 2010-2014. Teknik penentuan sampel yang digunakan adalah purposive sampling, sehingga sampel akhir yang didapatkan adalah 10 perusahaan yang tergabung dalam sektor industri barang konsumsi di Bursa Efek Indonesia periode 2010-2014. Teknik analisis data yang digunakan adalah uji asumsi klasik dan analisis regresi linear berganda dengan bantuan aplikasi SPSS 17 for windows . Berdasarkan hasil analisis menunjukkan bahwa investment opportunity set berpengaruh negatif namun tidak signifikan terhadap kebijakan dividen, total asset turn over berpengaruh positif dan signifikan terhadap kebijakan dividen, sales growth berpengaruh negatif namun tidak signifikan terhadap kebijakan dividen.