Miracle-dz/UniFAR-FTUs huggingface dataset:
Navigation and Control Design for the CanX-4/-5 Satellite Formation Flying Mission

Navigation and Control Design for the CanX-4/-5 Satellite Formation Flying Mission Niels Henrik Roth Master of Applied Science Institute for Aerospace Studies University of Toronto 2010 CanX-4/-5 is a formation flying technology demonstration mission that shall demonstrate submeter formation tracking control. The key to this precision control is carrier phase differential GPS state estimation, which enables centimeter-level relative state estimation. In this thesis, the formation flying controller design is reviewed in detail, and an innovative closed-loop formation reconfiguration strategy is presented. In addition, the designs of both coarseand fine-mode relative state estimators are presented. Formation flying simulations demonstrate the efficacy of the proposed control and coarse estimation. Furthermore, hardware tests are performed to test the computational efficiency of the control algorithms and to validate the fine-mode relative navigation filter.
Perceived Spousal Support and Beliefs Towards Cervical Smear Screening Among Chinese Women

Objective: Family is a major part of the social support network in Chinese society. This study examines the role of Chinese women’s perceived support from spouse on their cervical cancer screening beliefs and intention. Design: Participants were recruited from female family members of inpatients admitted to one of the major teaching hospitals in Taiwan (n=424). Screening intention, beliefs (perceived pros, cons, risk, and norms), and demographics were assessed via a self-administered survey. Women were classified into two groups based on their perceived spousal support towards having a cervical smear screening (low versus high). Results: Mean age of the sample was 34 years, 28% did not have high school education, 37% expressed no screening intention in the next 12 months, and 58% perceived their general health to be fair or poor. Women who perceived lower spousal support were more likely to be those without high school education (39% vs. 21%) or with lower perceived health status (65% vs. 54%). After adjusting for these demographic variables, multiple regression analyses revealed that women who perceived lower spousal support were associated with lower perceived benefits (B=-.210, p<.001), higher barriers (B=.228, p<.001), and lower norms towards cervical smear screening (B=-.127, p=.012). On the other hand, women who perceived higher spousal support were associated with positive intention to screening (OR=1.94; 95% C.I. = [1.28, 2.95]). Conclusion: The study shows that perceived spousal support could be an important factor that influences various beliefs towards cervical smear screening among Chinese women. Future research should consider examine factors associated with spousal support, as well as its impact on screening adoption among different ethnic groups. The current finding has implications on intervention programs targeting spouse or significant others on promoting gynecological cancer screenings among Asian women. © 2006 Californian Journal of Health Promotion. All rights reserved.
Evaluation of quality of life with alzheimer disease

Aim: In our study, the aim was to assess quality of life and associated factors among patients with Alzheimer disease (AD) and to collect data about reducing the disease load. Material and Methods: Our study was performed with 117 patients with possible AD diagnosis according to National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer’s Disease and Related Disorders Association (NINCDS-ADRDA) diagnostic criteria and 102 healthy individuals. The Whoqol-Brief (WB) was used to assess quality of life of individuals in the AD and control groups, while the Quality of Life-Alzheimer’s Disease (QOL-AD) scale was also administered to patients with AD. Results: There were no significant differences between the AD and control groups in terms of sex and gender (p=0.952; 0.186). In the AD group, points obtained in all WB areas were found to be significantly low compared to the control group (p=0.000). With increasing disease stage, disease duration and patient age, the WB subareas and QOL-AD patient/family/weighted points were observed to display a statistically significant level of decrease (p=0.000). All WB areas and QOL-AD patient/family/weighted points for those who were illiterate, received care support and lived with children or relatives (apart from QOL-AD family) were found to be statistically significant low compared to those who were literate, had attended primary/middle and high school, lived on their own and did not receive care support (p>0.05). Conclusion: Our data show that the quality of life of patients with AD is low. The fall in quality of life appears to be parallel to increasing disease stage, disease duration, patient age and low educational level, living outside their own home and care support needs.
Therapeutic potential of doramectin against canine sacroptic mange

Present study describes the haemato-biochemical analysis of dogs affected with sarcoptic mange and its treatment using doramectin. Study was undertaken on six client owned dogs confirmed to be suffering from sarcoptic mange irrespective of age, sex and breed presented at TVCC DUVASU, Mathura, while six healthy dogs were taken as control. There was significantly higher concentration of haematological parameters viz. total leucocyte count, eosinophil counts, mean corpuscular volume in scabetic dogs than respective control animals. On contrary mean concentration of haemoglobin, total erythrocyte count, haematocrit, lymphocyte counts decreased significantly in scabetic dogs than respective control animals. The biochemical parameters revealed significantly higher concentration of aspartate aminotransferase and alanine aminotransferase (30.14±0.60 μ/L vs 21.49±1.20 μ/L, 38.01±1.02 μ/L vs 28.33±3.72 μ/L; respectively) in scabetic dogs than in control while significant lower concentration of glucose, cholesterol, total protein and albumin in scabetic dogs than in control (46.83±1.57 mg/dL vs 70.33±3.16 mg/dL, 164.50±5.15 mg/dL vs 222.83±11.89 mg/dL, 4.46±0.11 gm/dL vs 6.06±0.06 gm/dL and 1.70±0.06 gm/dL vs 3.21±0.06 gm/dL; respectively). Cases were efficiently managed by using subcutaneous injections of doramectin @ 0.4 mg/kg body weight subcutaneously at weekly intervals along with standard treatment of pyoderma.
Reappraisal of Hepatocellular Adenoma from Federal Health System, Rio de Janeiro, Brazil

Background: Hepatocellular adenoma is a rare liver tumor that may require surgical treatment in cases of hemorrhage or suspicion of malignant lesions. Aim: To analyze data from patients who underwent hepatectomy for hepatocellular adenoma (HCA) in Rio de Janeiro, Brazil. Methods: From January 2005 to March 2019, sixty-nine patients with HCA underwent hepatectomy at centers in Rio de Janeiro. They were included in the analysis patients undergoing hepatectomy with pathological diagnosis of hepatocellular adenoma and excluded patients with hepatectomy with anatomopathological diagnosis other than hepatocellular adenoma, mainly nodular focal hyperplasia. Data related to patients, tumor and surgery were analyzed retrospectively. Results: Sixty patients (87%) were female and nine were male. Among women, 83% had a history of contraceptive use; among men, only one had an androgen intake history. Overall mean age was 36.4 years (15 - 49), with men older than women (33.9 ± 8.14 years vs. 40.4 ± 6.27 years; P = 0.02). Forty one patients reported abdominal pain, associated or not to other symptoms; 32% had an episode of hemorrhage; 28 were asymptomatic with an incidental radiological finding. In total, 45 patients presented only one lesion and overall mean size was 8.1 cm (2 - 31); tumors were larger among men (mean size 12.9 ± 9.86 cm vs. 7.7 ± 4.58 cm; P = 0.009). Twenty one surgeries were laparoscopic. Hepatocellular carcinoma (HCC) was identified in three specimens and the incidence was higher among men (22.2% vs. 1.6%; P = 0.042) and in tumors larger than 20 cm (66.6% vs. 0.02%). There was no perioperative mortality. Two of the three patients with HCC died with extrahepatic recurrence; the remaining patient is well after 36 months. Overall mean follow-up time was 14.2 months (2 - 76). Conclusion: Male patients with HCA were older and had larger tumors when compared to females. Incidence of HCC was higher among men and in lesions larger than 20 cm. Male patients with HCA should be treated more aggressively than females.
Therapy with Direct-Acting Antiviral Agents in Transplanted Patients with HCV Recurrence: A Retrospective Analysis

The recurrence of HCV infection after liver transplantation was the main cause of mortality and loss of graft in transplanted patients until the use of direct-acting antivirals (DAAs). We performed a monocentric retrospective study from November 2014 to September 2017 at “Ospedali Riuniti”, Ancona, Italy, to evaluate the outcome and tolerability of DAAs after liver transplantation. In total, 55 patients with HCV recurrence after liver transplantation treated with DAAs were included. The most frequent genotype was genotype 1a (36%), followed by genotype 3a (27%). The majority of the patients presented a mild or moderate hepatic fibrosis (METAVIR score of F0 F1 in 20% and F2 in 27%). The patients received sofosbuvir + daclatasvir, sofosbuvir + ribavirin, sofosbuvir + simeprevir, sofosbuvir + ledipasvir, and sofosbuvir + velpatasvir in 54%, 18%, 13%, 13%, and 2% of the cases, respectively, for 12 or 24 weeks. The SVR 12 rate was 89% overall, without a statistically significant relationship with genotypes, fibrosis stage, and therapy. Moreover, 52% of the patients modified the dosage of tacrolimus in the first three months of therapy with DAAs, without statistical significance compared to the group that not changed tacrolimus dosage. The most frequent adverse events were anemia associated with ribavirin. IFN-free treatment with DAAs is highly effective for HCV relapse after liver transplantation and it showed high tolerability in our patients.
Comparison of rating of perceived exertion scales during incremental and interval exercise

The Rating of Perceived Exertion (RPE) is an important measure of exercise intensity, which is useful both as a primary and adjunctive method of exercise prescription. However, there are multiple variants of the Borg RPE scale, primarily the Borg 6-20 RPE scale (BORG-RPE) and the Borg Category-Ratio-10 scale (BORG-CR10). There are inadequate data available to address the comparability and interchangeability of these two widely used scales. Well-trained non-athletes performed two increment cycle tests, with each scale used in a random sequence. Subjects also performed interval sessions at three intensities (50, 75 and 85% of peak power output) with each scale used in a random sequence. There were very large correlations during the incremental exercise between the conventional physiological measures (% heart rate reserve – r=0.89 & r=.87); and %VO2reserve (r=.88 & r=.90) and RPE measured by either the BORG-RPE or the BORGCR10, respectively. This pattern was also evident during the interval exercise (% heart rate reserve (r=.85 & r=.84; and blood lactate concentration – r=.74 & r=.78) and RPE measured by either the BORG-RPE or the BORG-CR10, respectively. The relationship between RPE measured by the BORG-RPE and the BORGCR10 was large and best described by a non-linear relationship for both the incremental (R2=89) and the interval (R2=.89) exercise. The incremental and interval curves were virtually overlapping. We concluded that the two most popular versions of the RPE scale, BORG-RPE and BORG-CR10, were both highly related to the conventional physiological measures and very strongly related to each other, with an easily described conversion.
Investigation of Fatigue in Hemodialysis Patients, Severity and Influencing Factors

Objective: This study was conducted in a descriptive manner to determine the severity of fatigue in patients undergoing hemodialysis due to Chronic Renal Failure (CRF) and to determine the socio-demographic factors affecting fatigue severity. Materials and Methods: The study was conducted between December 2017 and March 2018 on patients receiving treatment for CRF in the hemodialysis unit of the Malatya Training and Research Hospital. 225 hemodialysis patients were accepted who did not select the sample in the survey. In the evaluation of the data, the arithmetic mean, standard deviation and percentage parameters were used. In comparison, Oneway ANOVA, Kruskall-Wallis and Student t-test used. Results: When we look at the sociodemographic characteristics of hemodialysis patients and fatigue severity scale points in the study. There was a statistically significant relationship between age, gender, perceived health status, working status, duration of hemodialysis treatment, hemodialysis frequency and fatigue severity scale score (p<0.05). Conclusion: According to the results of the research; there was a statistically significant relationship between sociodemographic characteristics of hemodialysis patients and hemodialysis treatment duration and fatigue severity scale score.
Prevalence of depression among adolescent males in residential treatment

The following study looked at the prevalence of depression among males in a residential group home setting. The study used a quantitative research design. The Beck Depression Inventory was administered to fifty adolescent males ranging in age from twelve to eighteen. The participants were sampled at a group home facility in Yucaipa, California. A bivariate analysis was used in order to test the data. The study hypothesized that there was going to be a significant relationship between depression and male adolescents, who received less family support and fewer family visitations.
Expression of CXCR3 in different T cells subsets in rheumatoid arthritis

Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammatory polyarthritis as consequence, at least in part, of a T cell-driven inflammation in the synovial membrane, frequently associated with the production of pro-inflammatory cytokines, contributing for ongoing inflammation. CXCR3 have been implicated in RA, since it is known its ability to modulate migration and in addition an increased concentration of its ligands has been reported in RA. Hence in this study it was evaluated the frequency and absolute number of circulating CD4, CD8 and γδ T cells, as well as the distribution between naïve, effector, central memory and effector memory based on the CD27 and CD45RA expression. Furthermore minor T cells subsets were characterized according to the expression of CD62L and CD28 combined with CD27 and CD45RA; additionally the expression of CXCR3 was assessed in all the studied subsets. The frequency and absolute number of CD8 and γδ T cells were significantly decreased in RA patients; moreover CD4effector memory and CD8 naïve T cells were also decreased in frequency and absolute number in RA patients compared to healthy controls. In addition through the new T cells analysis, combining the expression of the CD45RA, CD27, CD28 and CD62L, it was found an impairment of five subsets within CD4 and CD8 T cells and nine subsets within γδ T cells in RA patients. Finally, the analysis of CXCR3 overall seems to indicate an increased expression in CD4 and CD8 T cells, conversely γδ T cells from RA patients showed lower CXCR3 expression. In conclusion, this study highlighted the importance of a detailed analysis of the T cell subsets through the combination of different phenotypic parameters. Our findings suggest an abnormal distribution of specific T cells subsets together with altered frequencies of T cell subsets expressing CXCR3 might contribute to a better knowledge of the migration pattern of these cells and therefore for the inflammatory status verified on RA patients.
Evaluation of knowledge and attitude about gingival displacement materials and techniques among dental practitioners

Statement of Problem: Edentulism is a condition that critically affects the quality of life of patients by compromising function as well as esthetics. Fixed partial dentures have been a treatment of choice to replace missing teeth. Despite its various advantages, failures are not uncommon. Recording accurate impressions is a crucial prerequisite to ensure the success of prosthesis. Gingival displacement, especially in restorations with subgingival margins, is extremely important to record the accurate impressions of the finish line. Aim and Objectives: The purpose of the study was to evaluate the knowledge and attitude about gingival displacement materials and techniques among dental practitioners in Nagpur region. Materials and Methods: A survey consisting of 15 questions regarding gingival deflection method was distributed among 200 dental practitioners. The participants were approached personally with the printed questionnaire and through E-mail. Results: The survey showed that approximately 86% of the dental practitioners practicing in Nagpur region did not perform gingival displacement before making impressions. Out of 16% of the dentists who perform gingival displacement, only 10% of them were prosthodontists. The most common method used for gingival displacement was retraction cord. Better techniques such as cordless gingival displacement were used by only 6% of the dentists because of lack of knowledge and technique sensitivity of these materials. Financial concerns may also be a deterrent for performing gingival displacement in such cases. Conclusion: Hands-on experiences on gingival displacement need to be imparted at the undergraduate level and the importance of gingival displacement for the success of prosthesis needs to be conveyed to dental practitioners, so as to bring about a change which results in a better rehabilitation of patients with partial edentulism.
Immediate Treatment of Burn Wounds with High Concentrations of Topical Antibiotics in an Alginate Hydrogel Using a Platform Wound Device.

Objective: There is an unmet need to improve immediate burn care, particularly when definitive treatment is delayed. Therefore, the purpose of this project was to formulate a hydrogel that contains very high concentrations of antibiotics and validate its use together with a platform wound device (PWD) for the immediate care of burns. Approach: The hydrogel properties were optimized by using a rheometer, differential scanning calorimetry, and liquid chromatography-mass spectrometry and were tested in an infected porcine burn model. Immediately, after burn creation, the burns were infected with different bacteria. Subsequently, the burns infected with Staphylococcus aureus, Pseudomonas aeruginosa, and Acinetobacter baumannii were covered with the PWD and treated with a single dose of hydrogel containing 1000 × minimum inhibitory concentration of vancomycin, gentamicin, and minocycline, respectively. On day 7 or 45, the animals were euthanized, and the burns were harvested for histology and quantitative bacteriology. Results: 0.625% was the best alginate concentration for the hydrogel in terms of viscosity, stability, and drug release. The porcine studies demonstrated that vancomycin-, gentamicin-, and minocycline-treated tissues contained significantly less bacteria and reduced depth of tissue necrosis in comparison to controls. Innovation: The PWD represents a platform technology that begins at the point of the first treatment by protecting the wound and allowing administration of topical therapeutics. The device can be adapted to enclose any size burn over any contour of the body. Conclusion: Antibiotics can be delivered safely in very high concentrations in a hydrogel using the PWD, and burn infections can be treated successfully with this method.
Inguinal Metastasis from Basal Cell Carcinoma of the Vulva

Vulval basal cell carcinomas (BCC) are an important differential diagnosis of painful, itchy vulval lesions, which can occur at all ages but commonly affect women in their senium. BCC tend to grow locally in an invasive and destructive pattern and seldom metastasize. Here we describe the rare case of inguinal metastasis in a 70-year-old woman with vulval BCC who was treated with radical hemivulvectomy, bilateral inguinal node sampling and adjuvant external beam radiotherapy. We discuss the clinical management of vulval BCC and provide an overview of the previously reported cases in the literature.
Breast Cancer in Megapolises of Kazakhstan: Epidemiological Assessment of Incidence and Mortality

Background: Breast cancer is the most common malignant disease among the female population of Kazakhstan like in many developed countries of the world (Canada, UK, US, Western Europe), and it accounts for every 5th tumor. We aimed to assess the epidemiological aspects of breast cancer incidence and mortality among Almaty and Astana (Now Nur-Sultan), Kazakhstan residents in 2009–2018. Methods: A retrospective study using modern descriptive and analytical methods of epidemiology was conducted to evaluate the breast cancer incidence and mortality in megapolises of Kazakhstan. Results: The average annual age-standardized incidence rate of breast cancer amounted to 61.9 00000 (95% CI=56.2–67.6) in Almaty and 61.2 00000 (95% CI=56.765.7) in Astana. The average age-standardized mortality was 19.2 00000 (95% CI=17.3–21.1) in Almaty and 19.3 00000 (95% CI=17.1–21.4) in Astana. The standardized incidence in the megapolises tended to increase (Tgr=+0.8% in Almaty and Tgr=+1.4% in Astana), while the mortality was decreasing (Tdec=−4.2% in Almaty and Tdec=−1.1% in Astana). According to the component analysis, the growth in the number of breast cancer cases was due to a population increase (ΔP=+130.4% in Almaty and ΔP=+93.2% in Astana), with a notable decrease of factors related to the risk of getting sick (ΔR=−27.9% in Almaty, ΔR=−6.1% in Astana). Conclusion: This is the first epidemiological study to assess the changes in incidence and mortality from breast cancer in megapolises of Kazakhstan because of screening. The results of this study can be used to improve the government program to combat breast cancer.
A multicentre prospective cohort study assessing the effectiveness of budesonide MMX® (Cortiment®MMX®) for active, mild-to-moderate ulcerative colitis

Background Cortiment®MMX® (budesonide MMX®) is currently approved for the induction of remission in mild-to-moderate ulcerative colitis (UC) patients when 5-ASA treatment is not sufficient. Data in real-life settings are lacking. Methods This was a multicentre observational prospective cohort study conducted in Europe and Canada. Effectiveness, safety, and tolerability of Cortiment®MMX® in a real-life setting of patients treated for mild-to-moderate UC was investigated. Patients were prescribed Cortiment®MMX® in accordance with the Summary of the Product Characteristics (SmPC). The primary endpoint was the clinical benefit of Cortiment® MMX® in routine practice (improvement ≥ 3 points in the clinical sub-scores of the Ulcerative Colitis Disease Activity Index, UCDAI). Results Data from 326 patients with mild-to-moderate UC were analysed for the primary endpoint. Clinical benefit was achieved in 60.1% (196/326) of patients at the end of Cortiment®MMX® treatment. Clinical remission (UCDAI clinical sub-score ≤ 1), full symptoms resolution (rectal bleeding (RB) = 0 and stool frequency (SF) = 0) and symptoms resolution (RB = 0 + SF ≤ 1) at the end of the Cortiment®MMX® treatment were achieved in 51.8%, 45.1% and 63.2% of patients, respectively. The median time to symptoms resolution was 30 days (range 29.0–36.0 days). Fifty patients (14.3%) had to discontinue Cortiment®MMX® due to adverse events; 17.5% of patients (n = 61) reported at least one adverse event related to the study drug. Conclusions This was the first time that a large cohort study was conducted with Cortiment®MMX® in a real-life setting. It demonstrated that Cortiment®MMX® is effective, safe and well tolerated in about 60% of UC patients.