Miracle-dz/UniFAR-FTUs huggingface dataset:
Immunomodulatory effect of mesenchymal stromal cells – REVIEW future science group high-risk acute myelogenous leukemia results in rapid engrafement

10.2217/17460751.3. 4.531 © 2 Co-transplantation of mesenchymal stem cells (MSCs) and hematopoietic stem cells ameliorate hematopoietic reconstitution and induce tolerance. The immunomodulatory properties of MSCs have been demonstrated both in vivo and in vitro. MSCs can modulate function of immune cells such as T lymphocytes, antigen-presenting cells and natural killer cells. However, it is unknown whether MSCs given to patients that have undergone HSC transplantation could alleviate graft versus leukemia effect or could increase the risk of the infection. Proper characterization of MSC immunomodulatory mechanisms are crucial to anticipate the possible effect of MSC in the host. In the current report, interesting and contradictory results in the literature are reviewed in an attempt to understand the underlying mechanism. Differences in experimental designs and models used seem to be the underlying causes of discrepancy in reported results. Results of the few in vivo studies are controversial and further clinical studies are needed to confirm the efficiency and safety of MSCs in transplantation management.
Finding Universals and Appreciating Differences： Philosophy and Method in Cross-Cultural Psychological Science

Despite the advances brought to psychology by multiculturalism and cultural diversity as a framework for social justice and improving human lives, there is a risk for what Bakan (1966) called “unmitigated agency” if multicultural and cultural diversity are reified as competencies that are then mandated in professional psychology training programs. A corrective alternative would be an integrative cross-cultural psychological science that would identify universals and appreciate differences across both individual personality and cultural contexts. Some of the principles for such an integrative applied cultural science are then generated, with examples, and a conceptual developmental model integrating biological factors (temperaments, endophenotypes), affect dynamics, attachment, and psychological type theory is offered.
Transition to adulthood in Georgia: dynamics of generational and gender roles in post-totalitarian society

During the past decade Georgia underwent drastic changes. The disintegration of Soviet Union in 1991 and subsequent establishment of independence in the South-Caucasian republic of Georgia was strongly linked with the population’s expectations of democratic development, prosperity and inclusion into global processes. However, it resulted in political instability leading to bloody ethno-territorial and civil wars, economic standstill, mass unemployment and impoverishment of population. Weakness of the state, mismanagement and lack of strategic thinking resulted in demolishing of the social security system and led to mass impoverishment. During these years the social stratification became more visible, partly due to increasing income gap between the new poor (more than a half of the population is considered to live below the poverty line) and the thin layer of the new rich who either used available financial and social resources to accumulate capital mainly through privatisation or trade, or acquired wealth through corruption. Another change is linked to the restructuring of political and economic system from Soviet centralized type to (embryonic) free market. Much of the new capital concentrates in the cities, while most of rural areas experience full economic stagnation, increasing another gap between rural and urban population, giving rise to growing migration to the capital city and other bigger urban centres, but also to emigration to other countries.
Parents can play a vital role in promoting safe driving to their teens

Introduction: Family communication patterns (FCPs) play an important role in reducing the risk-taking behaviors of teens, Jingzhen Yang, Associate Professor, University of Iowa Injury Prevention Research Center, Iowa City, IA, and Associate Professor, Department of Community and Behavioral Health, University of Iowa, Iowa City, IA. Shelly Campo, Associate Professor, Department of Community and Behavioral Health, University of Iowa, Iowa City, IA. Marizen Ramirez, Assistant Professor, University of Iowa Injury Prevention Research Center, Iowa City, IA, and Assistant Professor, Department of Occupational and Environmental Health, University of Iowa, Iowa City, IA. Julia Richards Krapfl, Health Educator, Center for Advocacy and Outreach, Blank Children s Hospital, Des Moines, IA. Gang Cheng, Doctoral student, University of Iowa Injury Prevention Research Center, Department of Biostatistics, University of Iowa, Iowa City, IA. Corinne Peek-Asa, Director, University of Iowa Injury Prevention Research Center, Iowa City, IA, and Professor, Department of Occupational and Environmental Health, University of Iowa,
Ecological Immunity and Kim Stanley Robinson’s 2312

In this paper, I will propose the notion of “ecological immunity” as a useful conceptual tool for thinking about the Anthropocene. The term refers to a basic condition of all life: in order to flourish, an organism must insulate itself from its environment and maintain a stable interior space which can support the organism’s vital functions, immunizing it against the dangerous flux of its ecological environment. The history of the human species can be written as a process by which this internal environment is progressively explicated and exteriorized. The Anthropocene marks the historical moment when these strategies for immunization reach an absolute limit: as the biosphere is itself revealed to be a finite interior, the outside disappears. It is no longer sufficient to immunize the human collective against the ecological environment; instead, the challenge becomes the maintenance of the biosphere as a whole, now understood as the last immunitary container. Kim Stanley Robinson’s science fiction novel 2312, I argue, can be read as an extended allegory of the problem of ecological immunity and a perceptive exploration of its biopolitical implications.
Summary of studies for prevalence of sleep disorders among children with an autism spectrum disorder

Introduction: This article will discuss the prevalence and types of sleep disorders experienced by children with autism spectrum disorders (ASDs), the risk factors for the development of sleep disorders among children with ASDs, the impact of sleep disorders on children with ASDs, and the role of the primary care provider (PCP) in diagnosing and treating sleep disorders among children with ASDs. Method: Review of published literature on the topic. Results: Children with ASDs are at risk for the development of chronic sleep disorders, which can have a negative impact on behavior. Both behavioral and pharmacological interventions exist for the treatment of sleep disorders among children with ASDs, with supplemental melatonin being the most widely studied and proven treatment. Discussion: PCPs will care for children with ASDs. Therefore, it is vital for PCPs to be knowledgeable about this topic and to promptly assess for and manage sleep disorders among children with ASDs. J Pediatr Health Care. (2015) -, -.
Do methodical traps lead to wrong development strategies for welfare? A multilevel approach considering heterogeneity across industrialized and developing countries

Subjective well-being (SWB) is becoming increasingly important as welfare concept in both scientific research and politics, as it comprises additional welfare aspects compared to the GDP per capita. Consequently, it becomes important to explicitly identify its driving forces and clarify still ambivalent findings of the literature. For this purpose, with a multilevel model we investigate the extent to which individual-level and national variables together influence subjective well-being. Moreover, we expect that life satisfaction of people in developing countries is determined differently than life satisfaction of people in industrialized countries. The database used includes both individual and national variables and is split into two subsamples of 40 industrialized countries and 41 developing countries. The results show that the national environment is highly important for a personi? ½s SWB. Thus, neglecting this national level would generate biased estimates. Moreover, the split into industrialized and developing countries shows that statistically significant and substantial differences in the effects on life satisfaction exist. Important differences are found for example regarding the income variables. We identify a saturation effect of income on the individual level, whose level is however different depending on the development status of the countries. Moreover, on the aggregated level a significant impact of GDP per capita is found for the developing but not for the industrialized countries. Thus, this study indicates that multilevel modelling approaches are necessary to obtain robust results and that the impact of macroeconomic variables diverges in dependence of the countryi? ½s development status.
Effects of familiarization on reliability of muscle-activation and gross efficiency in adolescents and adults

Abstract We investigated the effects of familiarization on the reliability of gross efficiency (GE) and lower-limb electromyography (EMG-rms) of adults and adolescents. We also evaluated the relationship between inter-test differences in GE and EMG-rms. Nine adult and nine adolescent cyclists performed three 10 min cycling tests at 50% of peak power output, separated by 48 h. Forty-five minutes familiarization visits were performed 24 h after each test. No differences were found across the tests for adult cyclists’ GE or EMG-rms, with Coefficient of Variation (CV%) ranging from 2.6 to 2.9% (GE) and 4.3 to 7.4%. Among adolescents, there was an increase in GE between tests 1 and 2 (p < 0.001) but not 2–3 (p = 0.438), with CVs decreasing from 6.8 to 2.6%. The adolescents’ EMG-rms decreased (p < 0.05) between tests 1 and 2, with CVs from 8.4 to 12.5%. There were no relationships (p > 0.05) between the inter-test differences of GE and EMG-rms. GE can be reliably determined; however, adolescents require two exposures to cycling. Without familiarization, adolescent EMG-rms is more variable than adults and would require larger samples to establish differences. The weak relationships between inter-test EMG-rms and inter-test GE questions the link between muscle activation and GE changes.
Near-pristine gas at high redshifts: a window on early nucleosynthesis

It has now become recognised that damped Lyman alpha systems play an important role in helping us unravel the origin of chemical elements. In this presentation, we describe the main results of a recently completed survey of the most metal-poor DLAs, aimed at complementing and extending studies of the oldest stars in the Galaxy. The survey has clarified a number of lingering issues concerning the abundances of C, N, O in the low metallicity regime, has revealed the existence of DLA analogues to Carbon-enhanced metal-poor stars, and is providing some of the most precise measures of the primordial abundance of Deuterium.
Segmental the Speech of the Aspects in Hearing Impaired

This article is to summarize some of the search findings on the speech characteristics of hearing -impaired speakers . This will present information on the articulatory or segmental aspects of hearing-impaired speakers . We indicated some of the points in this article . Segmental errors , as determined by phonetic transcriptions of hearing-impaired persons' speech , can be classified by the following four categories. 1) segmentation problem 2) nasalization 3) vowel errors: neutralization, diphthongization 4) consonant errors: omission , voicing errors, substitutions .
What Drives Smallholder Farmers’ Behaviour in the Potato Market in Uganda

Smallholder potato farmers in Uganda can be described as subsistence and in some cases self sufficient characterised with low or no surpluses for sale into the market. This study set out to bring to the fore front the factors that lead to observed smallholder farmers’ behaviour as net sellers, net buyers or autarkic in the market. Data were collected from 200 smallholder potato farmers in Kabale and Mbale districts. Descriptive statistics and an ordered probit model were used to analyse the data. Results showed that dependency ratio, square of distance from home to the market and a farmer having a transport means positively influenced net selling rather than net buying or net buying rather than autarky among smallholders.
Management of Vertebral Malignant Tumors: Clinical and Radiographic Study

26 patients underwent decompression-stabilization procedures for their malignant spinal lesions. Fifteen were females and 11 males. Their average age was 60.6 years (range 18-73 years). These patients were classified according to extent of involvement of the spine. One column was involved in 1/26 (3.8%) case, two in 11/26 cases (42.3%) and three in 14/26 cases (53.8%). A posterior approach alone was done in 8/26 (30.8%) patients while a combined anterior and posterior approaches were done in 18/26 (69.2%) cases. A variety of posterior stabilization procedures were used. Out of 24 patients who were able to attend the follow-up 16 (66.7%) were able to walk, five (20.8%) were paraparetic, and 3 patients (12.5%) were paraplegic. Patients with combined approach showed higher percentage of neurologic improvement (62%) while patients with posterior approach showed only 35% improvement in their neurologic status. Accordingly results obtained from direct anterior approaches using corpectomy and anterior reconstruction of the anterior and middle columns have produced the best results in terms of neurological improvement. Almost all of our patients had 2 or 3 columns involvement but the results did not support the three columns theory where we could not correlate any significant results, regarding pre- or post-operative radiographic measurements (mechanical instability) and pre- or post-operative neurologic findings (neurologic instability), with the number of involved columns.
Nitrous acid (HONO) during polar spring in Barrow, Alaska: A net source of OH radicals?

[1] HONO was measured by a LOPAP instrument (LOng Path Absorption Photometer) for one month during the OASIS spring 2009 campaign in Barrow, Alaska. HONO concentrations between ≤ 0.4 pptv (DL) and ∼500 pptv were measured. The very high concentrations observed on several days were caused by local direct emissions and were highly correlated with the NOx and CO data. When only “clean days” were considered, average HONO concentrations varied between ≤ 0.4 - 10 pptv. Average HONO/NOx and HONO/NOy ratios of ∼6% and ∼1% were observed, respectively, in good agreement with other remote LOPAP measurement data, but lower than measured in most other polar regions by other methods. The strong correlation between sharp peaks of OH and HONO during daytime, which was not observed for any other measured radical precursor, suggested that HONO photolysis was a major source of OH radicals in Barrow. This was supported by calculated net OH radical production by HONO and O3 photolysis for which the contribution of O3 (2%) could be neglected compared to that of HONO (98%). A net extra HONO/OH source necessary to explain elevated HONO levels during daytime of up to 90 pptv/h was determined, which was highly correlated with the actinic flux. Accordingly, a photochemical HONO source is proposed here, in good agreement with recent studies. From the higher correlation of the net HONO source with and [NO2] compared to and [NO3−], photosensitized conversion of NO2 on humic acid containing snow surfaces may be a more likely source of HONO in the polar atmosphere of Barrow than nitrate photolysis.
Differences in space use and habitat selection between captive‐bred and wild‐born houbara bustards in Saudi Arabia: results from a long‐term reintroduction program

In light of widespread declines of houbara bustard Chlamydotis macqueenii populations across its extant range, captive breeding has emerged as a viable option for regenerating viable populations of houbaras in addition to limiting hunting pressure, habitat management and amelioration of predation pressure. Although reintroductions of captive-bred houbaras have been carried out in many regions in recent years, information on differences in ranging behavior and habitat selection between captive-bred and wild-born houbaras is lacking. In this study, we utilized radiotelemetry data spanning 13 years to assess differences in home range use and habitat selection by houbara bustards in the Mahazat as-Sayd reserve in Saudi Arabia. The mean (standard error of the estimate) annual home range size, estimated using the Kernel density method, was 307.76 15.91 km 2 , and did not
PHYSICS OF LIQUIDS AND LIQUID SYSTEMS, BIOPHYSICS AND MEDICAL PHYSICS

V.YE. CHECHKO, 2 V.YA. GOTSULSKY 3 1 I.I. Mechnikov National University of Odessa, Chair of Theoretical Physics and Astronomy (42, Pasteur Str., Odessa 65082, Ukraine; e-mail: AstandPPWT@ukr.net) 2 I.I. Mechnikov National University of Odessa, Research and Development Institute of Physics (27, Pasteur Str., Odessa 65082, Ukraine; e-mail: AstandPPWT@ukr.net) 3 I.I. Mechnikov National University of Odessa, Chair of General and Chemical Physics (2, Dvoryanskaya Str., Odessa 65000, Ukraine; e-mail: vygot@onu.edu.ua)
Wind stability: forest layout and silviculture.

A study was made of aerial photographs that showed wind damage in Pinus radiata stands on the Canterbury Plains and in Kaingaroa State Forest. This study revealed a consistent and characteristic pattern of wind damage associated with exposed stand edges of closed canopy stands. These exposed edges resulted from forest margins, abrupt increases in stand height of at least 5 m, and breaks of at least 40 m confronting the oncoming damaging wind. The associated damage was usually concentrated in the first 100 m or 200 m of the stand downwind from these edges. This pattern of damage calls into question the safety of laying out stands in narrow strips with abrupt changes in height confronting a potentially hazardous wind, viz the "strip system" in Canterbury. Additionally, it was observed that in widely spaced stands, before canopy closure, there was no apparent fall off in damage downwind from exposed edges; wind forces acting on trees evidently remain high over the whole stand. The adoption of wide spacings on sites prone to wind damage could result in stands being less wind stable for at least part of the rotation. Where clearfelling in closed canopy stands has exposed a new face to a damaging wind, the consequent damage has often been severe, extending in long drives downwind. In some instances there appears to have been an upwind as well as a downwind exposure from clearfelling. Thinning temporarily increases risk of damage. This, and increasing vulnerability with stand height, indicates that thinning should be done as early as practicable. Butt log pruning can affect wind stability of young stands, but whether it has an advantageous or detrimental effect may depend on wind, stand, and site characteristics.
Negative Regulation of TRPA 1 by AMP-activated Protein Kinase in Primary Sensory Neurons as a Potential Mechanism of Painful Diabetic Neuropathy Running title : Negative Regulation of TRPA 1 by AMPK in DPN

1 Department of Pharmacy, School of Pharmacy, Hyogo University of Health Sciences. Kobe, Hyogo, Japan. 2 Traditional Medicine Research Center, Chinese Medicine Confucius Institute at Hyogo College of Medicine, Kobe, Hyogo, Japan. 3 Department of Anatomy and Neuroscience, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan. 4 Department of Anatomy and Cell Biology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.
Title: Acute hypoglycemia in healthy humans impairs insulin stimulated glucose uptake and glycogen synthase in skeletal muscle; a randomized clinical study. Short title: Hypoglycemia and insulin action in skeletal muscle

Hypoglycemia is the leading limiting factor in glycemic management of insulin-treated diabetes. Skeletal muscle is the predominant site of insulin-mediated glucose disposal and our study was designed to test to what extent insulin induced hypoglycemia affects glucose uptake in skeletal muscle and whether hypoglycemia counter-regulation modulates insulin and catecholamine signaling and glycogen synthase activity in skeletal muscle. Nine healthy volunteers were examined on three randomized study days in a crossover design: i) hyperinsulinemic hypoglycemia (bolus insulin), ii) hyperinsulinemic euglycemia (bolus insulin and glucose infusion) and iii) saline control with skeletal muscle biopsies taken just before, 30 min and 75 min after insulin/saline injection. During hypoglycemia glucose levels reached a nadir of ~2.0mmol/l and epinephrine rose to ~900pg/ml. Insulin stimulated glucose disposal and glucose clearance in skeletal muscle were impaired whereas insulin signaling to glucose transport was unaffected by hypoglycemia. Insulinstimulated glycogen synthase activity was completely ablated during hyperinsulinemic hypoglycemia and catecholamine signaling via PKA as well as phosphorylation of inhibiting sites on glycogen synthase all increased. Page 3 of 34 Diabetes
A factor preconditioning the young to diabetes?

RESULTS — Significant correlations were found between newborn and maternal serum CML (sCML) (r = 0.734, P = 0.001) serum methylglyoxal derivatives (sMGs) (r = 0.593, P = 0.001), and 8-isoprostanes (r = 0.644, P = 0.001). Infant adiponectin at 12 months negatively corre­ lated with maternal sCML (r = —0.467, P = 0.011), whereas high maternal sMGs predicted higher infant insulin or homeostasis model assessment (P = 0.027). Infant sAGEs significantly increased with the initiation of processed infant food intake, raising daily AGE consumption by ~7.5-fold in year 1.
Agency Conflicts in Public and Negotiated Transfers of Corporate Control

We analyze control transfers in firms with a dominant minority blockholder and otherwise dispersed owners, and show that the transaction mode is important. Negotiated block trades preserve a low level of ownership concentration, inducing more inefficient extraction of private benefits. In contrast, public acquisitions increase ownership concentration, resulting in fewer private benefits and higher firm value. Within our model, the incumbent and new controlling party prefer to trade the block because of the dispersed shareholders' free-riding behavior. We also explore the regulatory implications of this agency problem and its impact on the terms of block trades.
Temporal Estimates of Crop Growth in Sorghum and Maize Breeding Enabled by Unmanned Aerial Systems

We comprehensively validated the use of UAS in sorghum and maize breeding programs. Temporal estimates of plant growth will allow researchers to elucidate new phenotypes. The stage of the breeding pipeline dictates the applicability of UAS platforms. The implementation of UAS is demonstrated in different crop species. Monetary and time costs should be considered before implementation of UAS.