Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effect of Incorporation of 0.5 %wt. Silica Nanoparticles on the Micro Shear Bond Strength of a Resin Modified Glass Ionomer Cement

Statement of the Problem: The clinical success of glass ionomer restorations depends on the strength of resin-modified glass ionomer (RMGI) cement bonding to dentin and there is limited information available regarding the bond strength of resin modified glass ionomers containing silica nanoparticles to dental structures. Purpose: The aim of this study was to compare the microshear bond strength (µSBS) of RMGI with and without silica (SiO2) nanoparticles to dentin of permanent teeth. Materials and Method: In this experimental study, the occlusal surfaces of 30 freshly extracted intact third molars were ground to expose the flat dentin and after conditioning with 20% poly acrylic acid, were randomly assigned to two main groups (n=15). The first group was filled with RMGI (Fuji II LC, GC) and the second group was filled with RMGI plus 0.5%wt. silica nanoparticles. Then, each main group was divided into three subgroups, and then stored in an incubator at 37 oC with 100% humidity for 1, 7, and 30 days. The µSBS test was performed using a universal testing machine (1 mm/min). The data were analyzed by t-test, repeated measures ANOVA and Tukey test (p< 0.05). Results: There were no statistically significant differences between the mean µSBS of the groups with and without nanoparticles along the different storage periods (p> 0.05). There was significant difference in µSBS values among the three different storage periods in all the tested materials (p< 0.05). Conclusion: Incorporation of 0.5 %wt. silica nanoparticles did not compromise the µSBS of Fuji II LC RMGI to dentin.
Foam at inner eye canthus in office workers, compared with an average Danish population as control group

Abstract Foam formation in the eye canthus is well‐known. The presence of foam was observed in 169 office workers in 4 town halls in Copenhagen County compared with 112 control persons from the general population in the same area. The presence of foam depends on age and gender. A significant increase with age was observed in the control population (P=0.0078). In both groups, females had a significantly lower occurrence of foam than males (P=0.0043, P=0.010). This difference was mainly caused by the use of eye make‐up. After correction for age, gender and use of eye make‐up, the prevalence of foam was significantly lower in the office population than in the control population (P<0.0001). Furthermore, low foam formation was significantly correlated to reported subjective eye irritation in the office population (P=0.0074), but not in the control population (P=0.40). Also, significant positive correlation between absence of foam and different degrees of dry eyes (expressed as a combination of premature break‐up of the precorneal tearfilm and lissamine green stained epithelial damage of the bulbar conjunctiva) was found both in the office population and in the control population (P=0.0090, P=0.0034). However, after correction for the more frequent appearance of dry eyes in the office population, foam was still observed significantly less frequently in the office population than in the control population (P=0.0001). It is concluded that the decreased foam formation in the office worker constitutes a key symptom in the development of ‘office eye syndrome’. In what way the office environment influences the foam formation is unknown. Possible mechanisms are discussed.
Tracking Students’ Cognitive Processes During Program Debugging—An Eye-Movement Approach

This study explores students' cognitive processes while debugging programs by using an eye tracker. Students' eye movements during debugging were recorded by an eye tracker to investigate whether and how high- and low-performance students act differently during debugging. Thirty-eight computer science undergraduates were asked to debug two C programs. The path of students' gaze while following program codes was subjected to sequential analysis to reveal significant sequences of areas examined. These significant gaze path sequences were then compared to those of students with different debugging performances. The results show that, when debugging, high-performance students traced programs in a more logical manner, whereas low-performance students tended to stick to a line-by-line sequence and were unable to quickly derive the program's higher-level logic. Low-performance students also often jumped directly to certain suspected statements to find bugs, without following the program's logic. They also often needed to trace back to prior statements to recall information, and spent more time on manual computation. Based on the research results, adaptive instructional strategies and materials can be developed for students of different performance levels, to improve associated cognitive activities during debugging, which can foster learning during debugging and programming.
Breast and gastrointestinal cancer updates from ASCO 2015

Abstract This review focuses on the updates presented at the ASCO 2015 symposium in breast and gastrointestinal malignancies. Some were practice changing while others gave us an exciting glimpse into what′s to come in the very near future. Immunotherapy was the buzz word this year with data presented on every tumor site. Data on the efficacy of anti PD-1 agents in colorectal, hepatocellular and gastric cancer were presented. In breast cancer we saw data on a new and exciting therapeutic target in the form of androgen receptor among triple receptor negative breast tumors presented. Positive results of the PALOMA 3 trial were presented that has given women with hormone receptor positive metastatic breast cancer another therapeutic option. Furthermore data on strategies to further improve anti her2 therapy, optimizing of chemotherapy in the early and advanced stage and various strategies to improve endocrine therapy among patients with breast cancer were presented.
The Impact of Income Inequality on Growth: A Sensitiveness Analysis Across Different Political Regimes

This paper empirically examines the relationship between economic inequality and growth across democracies and dictatorships using the UTIP measure of household income inequality. The results show that the effects of income inequality on growth are negative and statistically significant regardless of the type of political regime. However, when the interaction term between the Gini index and per capita GDP is included in the set of regressors, we observe that the effect of inequality on growth varies with income levels differently for democracies and dictatorships. Specifically, the empirical findings indicate that income inequality has a generally economic stronger impact on growth under dictatorships than under democracies. A different attitude of political regimes toward redistribution coupled with credit market imperfections provides a potential explanation for such findings.
A review of thixotropy and its rheological modeling

We review thixotropy, its attributes, and accompanying rheological phenomena, such as yielding, hysteresis in shear-rate ramps, the influence of rest time and viscosity bifurcation, and the prevalence and importance of thixotropy in common fluids. While older work is reviewed in brief, the major emphasis is on recent developments, including nonmonotonic responses of stress to changes in strain rate, viscosity bifurcation, shear banding, and kinematic hardening. The major categories of phenomenological constitutive models are reviewed; these can include viscoelasticity and aging, plasticity, kinematic hardening, and thixotropy; and distinctions between these phenomena and thixotropy are discussed. A few available microstructural models are also reviewed, including population balance models and mesoscopic simulations. We end by highlighting important future work that is needed, including further development of microscopic models and their connection to phenomenological constitutive equations, detailed measurements of microstructures and flow fields with bands, and the investigation of flows other than simple shear.We review thixotropy, its attributes, and accompanying rheological phenomena, such as yielding, hysteresis in shear-rate ramps, the influence of rest time and viscosity bifurcation, and the prevalence and importance of thixotropy in common fluids. While older work is reviewed in brief, the major emphasis is on recent developments, including nonmonotonic responses of stress to changes in strain rate, viscosity bifurcation, shear banding, and kinematic hardening. The major categories of phenomenological constitutive models are reviewed; these can include viscoelasticity and aging, plasticity, kinematic hardening, and thixotropy; and distinctions between these phenomena and thixotropy are discussed. A few available microstructural models are also reviewed, including population balance models and mesoscopic simulations. We end by highlighting important future work that is needed, including further development of microscopic models and their connection to phenomenological constitutive equations, detailed measu.
Understanding teen dating violence: practical screening and intervention strategies for pediatric and adolescent healthcare providers

Purpose of review Teen dating violence (TDV) is a serious and potentially lethal form of relationship violence in adolescence. TDV is highly correlated with several outcomes related to poor physical and mental health. Although incidence and prevalence data indicate high rates of exposure to TDV among adolescents throughout the United States, significant confusion remains in healthcare communities concerning the definition and implications of TDV. Additionally, healthcare providers are uncertain about effective screening and intervention methods. The article will review the definition and epidemiology of TDV and discuss possible screening and intervention strategies. Recent findings TDV research is a relatively new addition to the field of relationship violence. Although some confusion remains, the definition and epidemiology of TDV are better understood, which has greatly led to effective ways in which to screen and intervene when such violence is detected. Universal screening with a focus on high-risk subgroups combined with referrals to local and national support services are key steps in reducing both primary and secondary exposure. Summary TDV is a widespread public health crisis with serious short-term and long-term implications. It is necessary for pediatric and adolescent healthcare providers to be aware of TDV and its potential repercussions, as well as possible methods for screening and intervention. More research is needed to better understand TDV as well as to further define effective screening and intervention protocol for the clinical environment.
Intraoperative Vancomycin Pharmacokinetics in Cardiac Surgery With or Without Cardiopulmonary Bypass

BACKGROUND Vancomycin is administered as antimicrobial prophylaxis to patients undergoing cardiac surgery, an intervention that usually requires cardiopulmonary bypass (CPB). Previous studies reported that CPB modifies vancomycin pharmacokinetic parameters. OBJECTIVE To investigate intraoperative vancomycin pharmacokinetic changes in a large population of patients undergoing cardiac surgery with CPB (on-pump) and without CPB (off-pump). METHODS In this prospective study, patients undergoing cardiac surgery received a single dose of vancomycin 1000 mg in a 60-minute intravenous infusion, with skin incision performed between 16 and 120 minutes after the end of the infusion. For the on-pump group, arterial samples were drawn before CPB (end of infusion, skin incision), during CPB (5, 30, and 60 minutes, and then every 60 minutes until CPB end), and after CPB (wound closure). For the off-pump group, arterial samples were drawn time-matched to the CPB period of the on-pump group. RESULTS Two hundred thirty-six consecutive patients were enrolled: 215 in the on-pump group and 21 in the off-pump group. A total of 1682 serum vancomycin concentrations (median 7/patient) were measured. Vancomycin maximum concentration ([Cmax] on-pump, 45.6 mg/L; off-pump, 47.3 mg/L); area under the concentration-time curve, zero to 8 hours ([AUC0–8] on-pump, 104.6 mg*h/L; off-pump, 96.1 mg*h/L); volume of distribution ([Vd] on-pump, 31 L; off-pump, 28.2 L); and total body clearance ([Cl] on-pump, 6.23 L/h; off-pump, 7.05 L/h) were similar. Moreover, Cmax and AUC0-∞ (AUC, zero to infinity) showed values comparable to those found in previous studies performed on noncardiac surgery patients. CONCLUSIONS In our study there were no significant differences in vancomycin Cmax, AUC0–8, Vd, and Cl between the on-pump and off-pump groups. CPB does not seem to significantly modify intraoperative vancomycin pharmaco ki netics in patients undergoing cardiac surgery. The results of this study may contribute to increased knowledge of vancomycin pharmacokinetics.
The Cost of Equity for Private Firms

The paper presents a method for calculating the cost of equity capital for the non-marketable securities of private firms and its difference from the cost of equity capital of an all else equal public firm (the private firm premium). The method is based on a theoretical framework that assumes the investor is undiversified due to her holdings in non-marketable securities. We implement the method for both unlevered and levered firms, and also consider the effect of taxes. The findings indicate that the private firm premium increases with the firm's asset risk, its leverage ratio, and the non-diversification of the private firm's owner, while taxes are negatively related to the private firm premium.
Interleukin‐34 is expressed by giant cell tumours of bone and plays a key role in RANKL‐induced osteoclastogenesis

Interleukin‐34 (IL‐34) is a newly discovered regulator of myeloid lineage differentiation, proliferation, and survival, acting via the macrophage‐colony stimulating factor receptor (M‐CSF receptor, c‐fms). M‐CSF, the main ligand for c‐fms, is required for osteoclastogenesis and has been already identified as a critical contributor of the pathogenesis of giant cell tumours of bone (GCTs), tumours rich in osteoclasts. According to the key role of M‐CSF in osteoclastogenesis and GCTs, the expression of IL‐34 in human GCTs was first assessed. Quantitative analysis of IL‐34 mRNA expression in 14 human GCTs revealed expression of this cytokine in GCTs as well as M‐CSF and c‐fms. Immunohistochemistry demonstrated that osteoclast‐like cells exhibited a huge immunostaining for IL‐34 and that mononuclear stromal cells were slightly positive for this protein. In contrast to osteoblasts, bone‐resorbing osteoclasts showed very strong staining for IL‐34, suggesting its potential role in the pathogenesis of GCTs by facilitating osteoclast formation. The role of IL‐34 in osteoclastogenesis was then studied in murine and human models. IL‐34 was able to support RANKL‐induced osteoclastogenesis in the absence of M‐CSF in all models. Multinucleated cells generated in the presence of IL‐34 and RANKL expressed specific osteoclastic markers and resorbed dentine. IL‐34 induced phosphorylation of ERK 1/2 and Akt through the activation of c‐fms, as revealed by the inhibition of signalling by a specific c‐fms tyrosine kinase inhibitor. Furthermore, IL‐34 stimulated RANKL‐induced osteoclastogenesis by promoting the adhesion and proliferation of osteoclast progenitors, and had no effect on osteoclast survival. Overall, these data reveal that IL‐34 can be entirely substituted for M‐CSF in RANKL‐induced osteoclastogenesis, thus identifying a new biological activity for this cytokine and a contribution to the pathogenesis of GCTs. Copyright © 2010 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Successful photodynamic therapy for subretinal neovascularisation due to Sorsby’s fundus dystrophy: 1 year follow up

Sorsby’s fundus dystrophy (SFD) is a rare but severe autosomal dominant disease. Clinically it is characterised by severe central visual loss, mainly due to submacular choroidal neovascularisation (CNV) during the fourth or fifth decade of life.1,2 Blindness therefore occurs during the patient’s most productive years of employment. We report a case of successful treatment of CNV in SFD with photodynamic therapy (PDT) and verteporfin. A 40 year old white man (occupation photographer) presented in 1999 with sudden blurring and distortion of vision in the right eye. Visual acuity was 6/6 in the right eye, and 6/4 in the left. Funduscopy and fundus fluorescein angiogram (FFA) demonstrated a large subfoveal CNV. This was deemed unsuitable for laser photocoagulation owing to its location and size. Subsequently, acuity in the right eye deteriorated to 3/60 with the formation of a disciform macular …
Can Admission Neutrophil to Lymphocyte Ratio Predict Infarct-Related Artery Patency in ST-Segment Elevation Myocardial Infarction

Objectives: In this study, we aimed to investigate the relationship between neutrophil to lymphocyte ratio (NLR) and infarct-related artery (IRA) patency in patients with ST-segment elevation myocardial infarction (STEMI). Methods: A total of 349 patients with STEMI were recruited to this retrospective study. Baseline characteristics were reviewed. Patency of IRA was evaluated by thrombolysis in myocardial infarction flow grade. Results: Of all patients, 293 patients formed the occluded IRA group and 56 patients formed the patent IRA group. The NLR was significantly higher in occluded IRA group (4.4 ± 4.1 vs 1.9 ± 1.1, P < .001). Glucose levels were also higher in occluded IRA group (171.3 ± 78.0 vs 144.7 ± 49.7, P = .022). Regression analysis demonstrated admission NLR and plasma glucose levels as independent predictors of IRA patency. Conclusion: In this study, we found that admission NLR and glucose levels were higher in patients with occluded IRA than in patients with STEMI. We also found that NLR and glucose levels were independent predictors of IRA patency. Because hemogram is a cheap, fast, and widely available test, it can be used in daily practice as a predictor of IRA patency.
Pharmacokinetics of AT-2266 Administered Orally to Mice, Rats, Dogs, and Monkeys

The pharmacokinetics of AT-2266 (1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine- 3-carboxylic acid) were studied in various experimental animals and compared in a number of aspects with those of norfloxacin. Both agents were administered orally. The mean peak plasma levels of AT-2266 in mice, rats, and dogs (given a single dose of 50 mg/kg for mice and rats and 25 mg/kg for dogs) were 2.39, 1.63, and 5.00 μg/ml, respectively, with elimination half-lives of 2.24, 2.81, and 5.76 h. The respective mean plasma levels of norfloxacin at similar dosages were 0.510, 0.410, and 0.700 μg/ml; elimination half-lives were 1.40, 2.35, and 6.06 h. In dogs repeatedly dosed with 25 mg of AT-2266 per kg every 12 h, the mean peak plasma levels after the third and fifth doses were about 1.4 times those after the first dose. The binding rates of AT-2266 and norfloxacin to plasma of mice, rats, and dogs and to human serum ranged from 27.6 to 40.2% and 39.8 to 44.2%, respectively. In rats receiving a single dose of 50 mg/kg, the respective mean peak levels of AT-2266 in plasma, lung, muscle, and kidney were 2.47, 4.60, 5.35, and 33.9 μg/ml or g, whereas those of norfloxacin were 0.234, 0.390, 0.272, and 2.05 μg/ml or g. AT-2266 was widely distributed in tissues of dogs and monkeys after repeated dosage. The respective 24-h recoveries of AT-2266 from urine of mice, rats, and dogs after single doses of 50, 50, and 25 mg/kg were 56.6, 40.5, and 64.1%, and recoveries of norfloxacin at these doses were 4.40, 2.91, and 5.34%. The respective 24-h recoveries of AT-2266 from bile and feces of rats given a single dose of 50 mg/kg were 2.47 and 52.7%. Bioautography of plasma and urine indicated that AT-2266 was metabolized to but a slight degree. The results indicate that AT-2266 is better than norfloxacin in oral absorption and similar to the latter in stability to metabolic inactivation.
Functional interactions among Orai1, TRPCs, and STIM1 suggest a STIM-regulated heteromeric Orai/TRPC model for SOCE/Icrac channels

Receptor-operated Ca2+ entry (ROCE) and store-operated Ca2+ entry (SOCE) into cells are functions performed by all higher eukaryotic cells, and their impairment is life-threatening. The main molecular components of this pathway appear to be known. However, the molecular make-up of channels mediating ROCE and SOCE is largely unknown. One hypothesis proposes SOCE channels to be formed solely by Orai proteins. Another proposes SOCE channels to be composed of both Orai and C-type transient receptor potential (TRPC) proteins. Both hypotheses propose that the channels are activated by STIM1, a sensor of the filling state of the Ca2+ stores that activates Ca2+ entry when stores are depleted. The role of Orai in SOCE has been proven. Here we show the TRPC-dependent reconstitution of Icrac, the electrophysiological correlate to SOCE, by expression of Orai1; we also show that R91W-Orai1 can inhibit SOCE and ROCE and that Orai1 and STIM1 expression leads to functional expression of Gd-resistant ROCE. Because channels that mediate ROCE are accepted to be formed with the participation of TRPCs, our data show functional interaction between ROCE and SOCE components. We propose that SOCE/Icrac channels are composed of heteromeric complexes that include TRPCs and Orai proteins.
Currency Substitution under Nonexpected Utility: Some Empirical Evidence

This paper derives and tests the restrictions implied by an optimizing model of currency substitution under nonexpected utility using quarterly data for Israel from 1978 to 1988. We find that the elasticity of intertemporal substitution is less than one, the elasticity of currency substitution is greater than one, relative risk aversion is about seven, and the elasticity of currency substitution is greater than the intratemporal elasticity of substitution between consumption and liquidity services. In most cases the evidence supports the hypothesis of nonexpected utility as well as the inclusion of liquidity services in the representative agent's objective function. The methodology of this paper can be applied to other interesting cases of currency substitution. Copyright 1993 by Ohio State University Press.