Miracle-dz/UniFAR-FTUs huggingface dataset:
Improving Inferences about Null Effects with Bayes Factors and Equivalence Tests.

Researchers often conclude an effect is absent when a null-hypothesis significance test yields a non-significant p-value. However, it is neither logically nor statistically correct to conclude an effect is absent when a hypothesis test is not significant. We present two methods to evaluate the presence or absence of effects: Equivalence testing (based on frequentist statistics) and Bayes factors (based on Bayesian statistics). In four examples from the gerontology literature we illustrate different ways to specify alternative models that can be used to reject the presence of a meaningful or predicted effect in hypothesis tests. We provide detailed explanations of how to calculate, report, and interpret Bayes factors and equivalence tests. We also discuss how to design informative studies that can provide support for a null model or for the absence of a meaningful effect. The conceptual differences between Bayes factors and equivalence tests are discussed, and we also note when and why they might lead to similar or different inferences in practice. It is important that researchers are able to falsify predictions or can quantify the support for predicted null-effects. Bayes factors and equivalence tests provide useful statistical tools to improve inferences about null effects.
The Effect of Low-Carbohydrate Diet on Glycemic Control in Patients with Type 2 Diabetes Mellitus

Objective: In China, a low-fat diet (LFD) is mainly recommended to help improve blood glucose levels in patients with type 2 diabetes mellitus (T2DM). However, a low-carbohydrate diet (LCD) has been shown to be effective in improving blood glucose levels in America and England. A few studies, primarily randomized controlled trials, have been reported in China as well. Method: Firstly, we designed two ‘six-point formula’ methods, which met the requirements of LCD and LFD, respectively. Fifty-six T2DM patients were recruited and randomly allocated to the LCD group (n = 28) and the LFD group (n = 28). The LCD group received education about LCD’s six-point formula, while the LFD group received education about LFD’s six-point formula. The follow-up time was three months. The indicators for glycemic control and other metabolic parameters were collected and compared between the two groups. Results: Forty-nine patients completed the study. The proportions of calories from three macronutrients the patients consumed met the requirements of LCD and LFD. Compared to the LFD group, there was a greater decrease in HbA1c level in the LCD group (−0.63% vs. −0.31%, p < 0.05). The dosages of insulin and fasting blood glucoses (FBG) in the third month were lower than those at baseline in both groups. Compared with baseline values, body mass index (BMI) and total cholesterol (TC) in the LCD group were significantly reduced in the third month (p < 0.05); however, there were no statistically significant differences in the LFD group. Conclusions: LCD can improve blood glucose more than LFD in Chinese patients with T2DM. It can also regulate blood lipid, reduce BMI, and decrease insulin dose in patients with T2DM. In addition, the six-point formula is feasible, easily operable, and a practical educational diet for Chinese patients with T2DM.
Dietary Sulfur-Containing Amino Acids Are Associated with Higher Prevalence of Overweight/Obesity in Northern Chinese Adults, an Internet-Based Cross-Sectional Study

Background/aims: Elevation of plasma sulfur-containing amino acids (SAAs) is generally associated with higher body mass index (BMI) and unfavorable lipid profiles. It is not known how dietary SAAs relate to these associations in humans. Methods: A convenient tool named internet-based dietary questionnaire for Chinese (IDQC) was used to estimate dietary SAAs intake. A total of 936 participants were randomly recruited and asked to complete the IDQC. Furthermore, 90 subjects were randomly selected to perform a subgroup study. The associations between dietary SAAs and prevalence of obesity, lipid profiles, and status of insulin resistance (IR), inflammation and oxidative stress were assessed. Results: Dietary total SAAs and cysteine of overweight/obese participants were significantly higher. Dietary total SAAs and cysteine were positively associated with BMI and waist circumference. Higher dietary total SAAs were associated with higher prevalence of overweight/obesity. Higher dietary total SAAs and cysteine also associated with higher serum triglyceride (total cholesterol), low density lipoprotein, fasting blood glucose, 2 h-postprandial glucose, and homeostasis model assessment of IR. In the subgroup study, positive associations between dietary SAAs and inflammation biomarkers were also observed. Conclusions: Dietary SAAs are associated with higher prevalence of overweight/obesity, unfavorable lipid profiles and status of IR, and inflammation.
SOXF factors regulate murine satellite cell self-renewal and function through inhibition of β-catenin activity

Muscle satellite cells are the primary source of stem cells for postnatal skeletal muscle growth and regeneration. Understanding genetic control of satellite cell formation, maintenance, and acquisition of their stem cell properties is on-going, and we have identified SOXF (SOX7, SOX17, SOX18) transcriptional factors as being induced during satellite cell specification. We demonstrate that SOXF factors regulate satellite cell quiescence, self-renewal and differentiation. Moreover, ablation of Sox17 in the muscle lineage impairs postnatal muscle growth and regeneration. We further determine that activities of SOX7, SOX17 and SOX18 overlap during muscle regeneration, with SOXF transcriptional activity requisite. Finally, we show that SOXF factors also control satellite cell expansion and renewal by directly inhibiting the output of β-catenin activity, including inhibition of Ccnd1 and Axin2. Together, our findings identify a key regulatory function of SoxF genes in muscle stem cells via direct transcriptional control and interaction with canonical Wnt/β-catenin signaling.
Design and nonlinear modeling of a sensitive sensor for the measurement of flow in mice

Objective: While many studies rely on flow and pressure measurements in small animal models of respiratory disease, such measurements can however be inaccurate and difficult to obtain. Thus, the goal of this study was to design and implement an easy-to-manufacture and accurate sensor capable of monitoring flow. Approach: We designed and 3D printed a flowmeter and utilized parametric (resistance and inertance) and nonparametric (polynomial and Volterra series) system identification to characterize the device. The sensor was tested in a closed system for apparent flow using the common mode rejection ratio (CMRR). The sensor properly measured tidal volumes and respiratory rates in spontaneously breathing mice. The device was used to evaluate a ventilator’s ability to deliver a prescribed volume before and after lung injury. Main results: The parametric and polynomial models provided a reasonable prediction of the independently measured flow (Adjusted coefficient of determination = 0.9591 and 0.9147 respectively), but the Volterra series of the 1st, 2nd, and 3rd order with a memory of six time points provided better fits ( = 0.9775, 0.9787, and 0.9954, respectively). At and below the mouse breathing frequency (1–5 Hz), CMRR was higher than 40 dB. Following lung injury, the sensor revealed a significant drop in delivered tidal volume. Significance: We demonstrate that the application of nonparametric nonlinear Volterra series modeling in combination with 3D printing technology allows the inexpensive and rapid fabrication of an accurate flow sensor for continuously measuring small flows in various physiological conditions.
Serum Caspase-Cleaved Cytokeratin (M30) Indicates Severity of Liver Dysfunction and Predicts Liver Outcome

Background The Model for End-Stage Liver Disease (MELD) score is a well-established tool for assessing hepatic failure. The present retrospective study investigated whether serum keratin 18 (M65) and caspase-cleaved cytokeratin (M30) were associated with liver dysfunction and post-transplant graft failure. Material/Methods A total of 147 patients with liver cirrhosis were categorized into 2 groups according to their baseline MELD score (group I: MELD score <20, n=87, and group II: MELD score ≥20, n=60). Serum M65 and M30 levels were measured by ELISA. Results Cirrhotic patients had significantly higher serum M65 and M30 levels than healthy controls (p<0.0001). Serum M65 was correlated with the MELD score and serum bilirubin (p≤0.007) and serum M30 was correlated with the MELD score, international normalized ratio, and serum bilirubin (p≤0.001). Group II had significantly higher serum M65 and M30 levels than group I (M65, p=0.025 and M30, p<0.001). Patients who lost the allograft during the first post-transplant year had significantly higher serum M30 levels than patients with a graft survival of >1 year (p=0.004). In the regression analysis, serum M30 was associated with the MELD score (odds ratio [OR]=2.545, p=0.005), serum bilirubin (OR=2.605, p=0.005) and 1-year graft loss (OR=3.61, p=0.006). Conclusions Our data indicate that serum M30 levels reflect the degree of liver dysfunction and can predict 1-year graft loss.
Association of Iodine Deficiency With Hearing Impairment in US Adolescents Aged 12 to 19 Years: Analysis of NHANES 2007-2010 Data

Association of Iodine Deficiency With Hearing Impairment in US Adolescents Aged 12 to 19 Years: Analysis of NHANES 2007-2010 Data Hearing impairment is poorly recognized and underreported. Thyroid hormones are necessary for maturation of the cochlea and the central auditory areas.1 Congenital and acquired hypothyroidism in humans are associated with hearing impairment2; in animal models, higher auditory thresholds have been reported in animals with induced hypothyroidism.2 Because iodine is an essential component of thyroid hormones, iodine deficiency may impair hearing by contributing to thyroid dysfunction. Few studies have investigated the relationship between iodine deficiency and hearing impairment. Speech-frequency hearing loss (SFHL) is more severe in preschool-aged children with urinary iodine concentrations (UICs) less than 100 μg/L.3 Reports of improved auditory function after iodine supplementation may indicate a possible association.2
Hypoxic Tumor-Derived Exosomal miR-301a Mediates M2 Macrophage Polarization via PTEN/PI3Kγ to Promote Pancreatic Cancer Metastasis.

Exosomes are emerging as important mediators of the cross-talk between tumor cells and the microenvironment. However, the mechanisms by which exosomes modulate tumor development under hypoxia in pancreatic cancer remain largely unknown. Here, we found that hypoxic exosomes derived from pancreatic cancer cells activate macrophages to the M2 phenotype in a HIF1a or HIF2a-dependent manner, which then facilitates the migration, invasion, and epithelial-mesenchymal transition of pancreatic cancer cells. Given that exosomes have been shown to transport miRNAs to alter cellular functions, we discovered that miR-301a-3p was highly expressed in hypoxic pancreatic cancer cells and enriched in hypoxic pancreatic cancer cell-derived exosomes. Circulating exosomal miR-301a-3p levels positively associated with depth of invasion, lymph node metastasis, late TNM stage, and poor prognosis of pancreatic cancer. Hypoxic exosomal miR-301a-3p induced the M2 polarization of macrophages via activation of the PTEN/PI3Kγ signaling pathway. Coculturing of pancreatic cancer cells with macrophages in which miR-301a-3p was upregulated or treated with hypoxic exosomes enhanced their metastatic capacity. Collectively, these data indicate that pancreatic cancer cells generate miR-301a-3p-rich exosomes in a hypoxic microenvironment, which then polarize macrophages to promote malignant behaviors of pancreatic cancer cells. Targeting exosomal miR-301a-3p may provide a potential diagnosis and treatment strategy for pancreatic cancer.Significance: These findings identify an exosomal miRNA critical for microenvironmental cross-talk that may prove to be a potential target for diagnosis and treatment of pancreatic cancer.Graphical Abstract: http://cancerres.aacrjournals. org/content/canres/78/16/4586/F1.large. jpg Cancer Res; 78(16); 4586-98. ©2018 AACR.
Cortical Excitability and Interhemispheric Connectivity in Early Relapsing–Remitting Multiple Sclerosis Studied With TMS-EEG

Evoked potentials (EPs) are well established in clinical practice for diagnosis and prognosis in multiple sclerosis (MS). However, their value is limited to the assessment of their respective functional systems. Here, we used transcranial magnetic stimulation (TMS) coupled with electroencephalography (TMS-EEG) to investigate cortical excitability and spatiotemporal dynamics of TMS-evoked neural activity in MS patients. Thirteen patients with early relapsing–remitting MS (RRMS) with a median Expanded Disability Status Scale (EDSS) of 1.0 (range 0–2.5) and 16 age- and gender-matched healthy controls received single-pulse TMS of left and right primary motor cortex (L-M1 and R-M1), respectively. Resting motor threshold for L-M1 and R-M1 was increased in MS patients. Latencies and amplitudes of N45, P70, N100, P180, and N280 TMS-evoked EEG potentials (TEPs) were not different between groups, except a significantly increased amplitude of the N280 TEP in the MS group, both for L-M1 and R-M1 stimulation. Interhemispheric signal propagation (ISP), estimated from the area under the curve of TEPs in the non-stimulated vs. stimulated M1, also did not differ between groups. In summary, findings show that ISP and TEPs were preserved in early-stage RRMS, except for an exaggerated N280 amplitude. Our findings indicate that TMS-EEG is feasible in testing excitability and connectivity in cortical neural networks in MS patients, complementary to conventional EPs. However, relevance and pathophysiological correlates of the enhanced N280 will need further study.
Analysis of salivary phenotypes of generalized aggressive and chronic periodontitis through nuclear magnetic resonance-based metabolomics.

BACKGROUND Recent findings about the differential gene expression signature of periodontal lesions have raised the hypothesis of distinctive biological phenotypes expressed by generalized chronic periodontitis (GCP) and generalized aggressive periodontitis (GAgP) patients. Therefore, this cross-sectional investigation was planned, primarily, to determine the ability of nuclear magnetic resonance (NMR) spectroscopic analysis of unstimulated whole saliva to discriminate GCP and GAgP disease-specific metabolomic fingerprint and, secondarily, to assess potential metabolites discriminating periodontitis patients from periodontally healthy individuals (HI). METHODS NMR-metabolomics spectra were acquired from salivary samples of patients with a clinical diagnosis of GCP (n = 33) or GAgP (n = 28) and from HI (n = 39). The clustering of HI, GCP, and GAgP patients was achieved by using a combination of the Principal Component Analysis and Canonical Correlation Analysis on the NMR profiles. RESULTS These analyses revealed a significant predictive accuracy discriminating HI from GCP, and discriminating HI from GAgP patients (both 81%). In contrast, the GAgP and GCP saliva samples seem to belong to the same metabolic space (60% predictive accuracy). Significantly lower levels (P < 0.05) of pyruvate, N-acetyl groups and lactate and higher levels (P < 0.05) of proline, phenylalanine, and tyrosine were found in GCP and GAgP patients compared with HI. CONCLUSIONS Within the limitations of this study, CGP and GAgP metabolomic profiles were not unequivocally discriminated through a NMR-based spectroscopic analysis of saliva.
The Effects Of Swimming And Dry-Land Resistance Training Programme On Non-Swimmers

Abstract Introduction. The aim of the study was to estimate the influence of combined swimming and dry-land resistance training on swimming force, swimming performance and strength in non-swimmers. Material and methods. Thirty male non-swimmers took part in the research. They were randomly assigned to one of the two groups: experimental (n=17) and control (n=13). The experimental group took part in combined swimming and dry-land resistance training. The control group took part in swimming training only. The swimming and dry-land resistance training programme lasted twelve weeks (48 training sessions of swimming and 36 sessions of dry-land resistance training). Average training volume and intensity were the same for all swimmers throughout the study protocol. The training programme included dominant aerobic work in front crawl. Results. Dry-land resistance training applied in the experimental group significantly improved the upper body strength. In spite of the theory that dry-land strength training is probably not specific enough to improve the sprint swim performance, the experimental group tended to demonstrate greater improvement in sprint performance. The imitation of the underwater phase of shoulder work during front crawl provided by the ergometer can be a useful training method in non-swimmers.
Agricultural Productivity Growth in Latin America and the Caribbean and Other World Regions: An Analysis of Climatic Effects, Convergence and Catch-up

This study estimates Climate Adjusted Total Factor Productivity (CATFP) for agriculture in Latin America and Caribbean (LAC) countries, while also providing comparisons with several regions of the world. Climatic variability is introduced in Stochastic Production Frontier (SPF) models by including average annual maximum temperature, precipitation and its monthly intra-year standard deviations, and the number of rainy days. Climatic conditions have a negative impact on production becoming stronger at the end of the 2000s compared to earlier periods. An Error Correction Model is applied to investigate catch-up and convergence across LAC countries. Argentina defines the frontier in LAC and TFP convergence is found across all South American countries, Costa Rica, Mexico, Barbados and The Bahamas. Using IPCC 2014 scenarios, the study shows that climatic variability induces significant reductions in productivity (2.3% to 10.7%), over the 2013-2040 period. Estimated output losses due to climatic variability range from 9% to 20% in the LAC region depending on the scenario considered.
De jure determinants of new firm formation: how the pillars of constitutions influence entrepreneurship

This paper provides empirical evidence supporting the view that constitutions are the primary and fundamental institutional determinant of entrepreneurship. It shows that some of the provisions contained in national constitutions are positively and significantly associated with a standard measure of entrepreneurial dynamics, namely the rate of new business density. Using for 115 countries a novel dataset containing the characteristics of the constitutions enacted in the world, applying an IV-GMM treatment to deal with the endogeneity of constitutional rules, and controlling for de facto variables, the paper finds that provisions about the right to conduct/establish a business, the right to strike, consumer protection, anti-corruption, and compulsory education promote higher rates of new firm formation. Contrasting results are instead obtained for provisions concerning protection of intellectual property rights.
Mineworker fatigue: A review of what we know and future decisions.

Fatigue presents several challenges for the mining industry. Depending on the specific occupation, daily work or operational setup on any given mine site, mining jobs can have a fair amount of labor-intensive tasks mixed with monotonous and repetitive duties. Combined with the long working hours and shift-work schedules of mining work, the prevalence of fatigue in mine workers may seem rather unsurprising.
Behavioral syndromes influence mating systems: Floater pairs of a lizard have heavier offspring.

Variation in correlated behaviors or behavioral syndromes could have interesting effects on mating systems, especially if the variation in syndrome exists in both sexes. Both males and females of the lizard Eulamprus heatwolei display two behavioral types of a behavioral syndrome, defined by correlations between territorial, exploratory, and predator avoidance behaviors. We tested how this variation in behavioral syndrome influences reproductive success, pairing patterns, and offspring weight. We used spatial behavior and residency in the field to identify territorial and floater individuals. Females were relocated to the laboratory to give birth, and all offspring, dams, and potential sires were genotyped to determine offspring paternity. During field surveys, 164 lizards were caught of which 27.5% were territorial and the rest were floaters. Paternity was assigned to 66% of the 104 offspring produced by 33 dams. Territorial sires fathered a greater proportion of the offspring of territorial dams than floater sires. Larger territorial males were more likely to sire the entire clutch or share paternity with fewer additional sires than smaller territorial males. Floater sire size, however, did not influence the number of fathers per litter. Floater females produced heavier offspring than their territorial counterparts, and offspring fathered by floaters were heavier than maternal half-sibs fathered by territorial males. We speculate that differences in offspring weight may be the result of differences in yolk provisioning by females and parent genetic compatibility. Key words: Eulamprus heatwolei, multiple paternity, offspring quality, personalities. [Behav Ecol]
The Strategic Meaning of CBCA Criteria From the Perspective of Deceivers

In 2014, Volbert and Steller introduced a revised model of Criteria-Based Content Analysis (CBCA) that grouped a modified set of content criteria in closer reference to their assumed latent processes, resulting in three dimensions of memory-related, script-deviant and strategy-based criteria. In this model, it is assumed that deceivers try to integrate memory-related criteria—but will not be as good as truth tellers in achieving this—whereas out of strategic considerations they will avoid the expression of the other criteria. The aim of the current study was to test this assumption. A vignette was presented via an online-questionnaire to inquire how participants (n = 135) rate the strategic value of CBCA criteria on a five-point scale. One-sample t-tests showed that participants attribute positive strategic value to most memory-related criteria and negative value to the remaining criteria, except for the criteria self-deprecation and pardoning the perpetrator. Overall, our results corroborated the model's suitability in distinguishing different groups of criteria—some which liars are inclined to integrate and others which liars intend to avoid—and in this way provide useful hints for forensic practitioners in appraising the criteria' diagnostic value.
Legionella Pneumonia Complicated with Acquired Fanconi Syndrome

Legionella pneumonia is occasionally accompanied by renal complications; however, the cause of this remains unknown. We herein report a 70-year-old Japanese man with Legionella pneumonia who presented with hyponatremia, hypophosphatemia, and hypouricemia. The levels of urinary β2-microglobulin and N-acetyl-β-D-glucosaminidase were remarkably high, indicating severe renal tubular damage. The presence of glycosuria and aminoaciduria as well as increased fractional excretion of uric acid and decreased tubular reabsorption of phosphate indicated that the patient's condition was complicated with Fanconi syndrome. After antimicrobial therapy, the electrolyte abnormalities and renal tubular damage were completely resolved.