Miracle-dz/UniFAR-FTUs huggingface dataset:
Conceptualizing patient-reported outcome measures for use within two Danish psychiatric clinical registries: description of an iterative co-creation process between patients and healthcare professionals

Abstract Background: Denmark has national clinical indicator programs for adult patients diagnosed with depression and schizophrenia, respectively. Within each program, the responsible steering group (SG) decided to add some indicators based upon patient-reported outcome measures (PROMs). Aims: The primary aim was to describe the process of selecting PROMs and defining a national measurement concept for use in clinical practice and for indicator monitoring and the secondary aim s to collect patient recommendations for implementation. Methods: An interdisciplinary SG of healthcare professionals and a Patient Peer Board (PPB) representing both patient groups co-created the output in an iterative process. The work included literature search, PPB workshops, SG meetings, ratings of PROM topics and items, and a pilot. The PPB discussed the following: item relevance, mode of data collection, graphical format of the online PROMs, and display of results. Finally, requirements for PROM patient information were identified. Based upon input from the PPB, the SG selected the items and specified the measurement concept. Results: The PPB prioritized 20 of 53 suitable items and suggested alternative wording and answer categories. A pilot was performed and 19 items covering well-being, lack of well-being, impairment of functioning, and overall health were selected for clinical testing. The patients recommended concrete, unambiguous, easily understandable information and procedures for data collection and display of results. Conclusions: The iterative co-creation process based upon a high degree of patient involvement resulted in a set of PROMs, a national measurement concept, and patient recommendations for implementation. The cooperation between patients and professionals was successful.
Alterations in necroptosis during ALDH2-mediated protection against high glucose-induced H9c2 cardiac cell injury

The aim of the present study was to investigate whether necroptosis occurs in high glucose (HG)-induced H9c2 cardiac cell injury and whether the activation of aldehyde dehydrogenase 2 (ALDH2) can inhibit necroptosis. H9c2 cardiac cells were treated with 35 mM glucose to establish a HG-induced cell injury model. Alda-1 (20 µM), a specific activator of ALDH2 and necrostatin-1 (Nec-1, 100 µM), an inhibitor of necroptosis were used to treat H9c2 cardiac cells under HG conditions. Cell viability was measured using a Cell Counting Kit-8 assay and reactive oxygen species (ROS) generation was measured by the dihydroethidium staining method. ALDH2 activity was measured at 450 nm. The mRNA and protein expression of ALDH2, necroptosis-associated genes, receptor-interacting protein (RIP)1, RIP3 and mixed lineage kinase domain like pseudokinase (MLKL), were analyzed by reverse transcription-quantitative polymerase chain reaction and western blotting. The expression of cleaved caspase-3 protein was also examined by western blotting. The results demonstrated that under HG conditions, cell viability, ALDH2 activity, mRNA and protein expression were decreased. Furthermore, ROS generation, mRNA and protein expression of RIP1, RIP3, MLKL and the protein expression of cleaved caspase-3 were increased. Treatment with Alda-1 or Nec-1 attenuated HG-induced downregulation of ALDH2 activity, mRNA and protein expression. In addition, RIP1, RIP3, MLKL mRNA, and protein expression were downregulated. Furthermore, Alda-1 but not Nec-1 decreased cleaved caspase-3 protein expression. Collectively these data indicated that activation of ALDH2 protected H9c2 cardiac cells against HG-induced injury, partly by inhibiting the occurrence of necroptosis.
Report of Joint AIEE-EEI Subject Committee on Line Outages [includes discussion]

The Subject Committee on Line Outages was formed jointly in 1947 by the Transmission and Distribution Committees of the Edison Electric Institute (EEI) and the AIEE to obtain fundamental operating data of transmission line outages. Previous line outage studies have considered special aspects of the subject. The present survey is intended to consider all types of line outages over a broad range of system voltages. The primary objectives are: 1. To obtain fundamental data as to the causes of present-day transmission line outages. 2. To correlate the cause of outages with the transmission line and system characteristics. 3. To summarize this information so as to provide assistance for transmission line design and operation. The scope of this survey is limited to overhead transmission circuits. The data used in the line outage study have been submitted by 62 operating companies which are classified in seven regions. The line outage report considers the physical data and line performance records of 689 transmission lines having a total of 33,796 miles of transmission line above 100 kV and embraces 236,666 mile-years of operating experience. These data are shown in detail in tabular form.
Melatonin in Prevention of the Sequence from Reflux Esophagitis to Barrett’s Esophagus and Esophageal Adenocarcinoma: Experimental and Clinical Perspectives

Melatonin is a tryptophan-derived molecule with pleiotropic activities which is produced in all living organisms. This “sleep” hormone is a free radical scavenger, which activates several anti-oxidative enzymes and mechanisms. Melatonin, a highly lipophilic hormone, can reach body target cells rapidly, acting as the circadian signal to alter numerous physiological functions in the body. This indoleamine can protect the organs against a variety of damaging agents via multiple signaling. This review focused on the role played by melatonin in the mechanism of esophagoprotection, starting with its short-term protection against acute reflux esophagitis and then investigating the long-term prevention of chronic inflammation that leads to gastroesophageal reflux disease (GERD) and Barrett’s esophagus. Since both of these condition are also identified as major risk factors for esophageal carcinoma, we provide some experimental and clinical evidence that supplementation therapy with melatonin could be useful in esophageal injury by protecting various animal models and patients with GERD from erosions, Barrett’s esophagus and neoplasia. The physiological aspects of the synthesis and release of this indoleamine in the gut, including its release into portal circulation and liver uptake is examined. The beneficial influence of melatonin in preventing esophageal injury from acid-pepsin and acid-pepsin-bile exposure in animals as well as the usefulness of melatonin and its precursor, L-tryptophan in prophylactic and supplementary therapy against esophageal disorders in humans, are also discussed.
Quantum Effects in Communications Systems

The information capacity of various communications systems is considered. Quantum effects are taken fully into account. The entropy of an electromagnetic wave having the quantum statistical properties of white noise in a single transmission mode is found, and from it the information efficiency of various possible systems may be derived. The receiving systems considered include amplifiers, heterodyne and homodyne converters and quantum counters. In the limit of high signal or noise power (compared to hνB, where h is Planck's constant and ν and B are, respectively, the center frequency and bandwidth of the channel) the information efficiency of an amplifier can approach unity. In the limit of low powers the amplifier becomes inefficient, while the efficiency of the quantum counter can approach unity. The amount of information that can be incorporated in a wave drops off rather rapidly when the power drops below hνB.
Noise Figures of Radio Receivers

A rigorous definition of the noise figure of radio receivers is given in this paper. The definition is not limited to high-gain receivers, but can be applied to four-terminal networks in general. An analysis is made of the relationship between the noise figure of the receiver as a whole and the noise figures of its components. Mismatch relations between the components of the receiver and methods of measurements of noise figures are discussed briefly.
Theory of Noisy Fourpoles

The well-known theory of fourpoles only comprises passive fourpoles and active fourpoles with internal sources of sinusoidal currents or voltages of defined frequencies. This theory is now completed for fourpoles with internal noise sources. Simple equivalent circuits are derived for such networks. They consist of the original but noise-free fourpole cascaded with a preceding noise fourpole in which all noise-sources are concentrated. The latter contains the equivalent noise conductance G. , the equivalent noise resistance Rn and the complex correlation admittance Ycor. With these quantities the noise behavior of any desired fourpole can be described sufficiently. In particular it is possible to calculate the noise figure F and its dependence on the matching conditions to the signal source of a single fourpole or a group of cascaded fourpoles. The methods of experimental determination of the elements of the noise fourpoles are discussed. The same theory is also useful for mixer-circuits as well as fortraveling-wave tubes and transistors, as application results are given for grid controlled electron tubes.
Saturated synchronous machines under transient conditions in the pole axis

THE performance of synchronous machines in steady-state operation, as well as in the transient state, is substantially determined by magnetic saturation in their iron circuits.13,14,20 It is well-known that high initial and sustained short-circuit currents develop under widely different conditions of saturation and that large capacitive loading is unstable but for the effect of saturation.
Profile of evolocumab and its cost-effectiveness in patients with high cardiovascular risk: literature review

ABSTRACT Introduction: Evolocumab is fully human monoclonal antibody which binds to proprotein convertase subtilisin/kexin type 9 (PCSK9), and prevents its blocking effect on recycling of liver low-density lipoprotein (LDL) receptors. Areas covered: The aim of this review is to assess efficacy, safety, and cost-effectiveness of evolocumab in adult patients with high cardiovascular risk. Major research databases MEDLINE, EBSCO, and CENTRAL were systematically searched for relevant study reports. Expert commentary: Even when given in full doses, statins augmented with ezetimibe and cholesterol-binding resins could not reduce cholesterol baseline level for more than 66%, while evolocumab reduces cholesterol level for 75% or even more. Up to now, evolocumab showed good safety profile, and patents tolerate it very well. The abovementioned advantages of evolocumab made it almost ideal drug for hypercholesterolemia, and probably in the future the best drug for secondary prevention of major cardiovascular events. Evolocumab is borderline cost-effective for the treatment of patients with high cardiovascular risk in European countries, while in the U.S.A. it is under debate where the underlying assumption (risk of cardiovascular disease events) determine the true value.
The calculation of unbalanced magnetic pull in synchronous and induction motors

Discussion and author's closure of paper 43–99 by R. C. Robinson, presented at the AIEE national technical meeting, Cleveland, Ohio, June 21–25, 1943, and published in AIEE TRANSACTIONS, 1943, October section, pages 620–4.
Reoperation Rate After Microsurgical Uni- or Bilateral Laminotomy for Lumbar Spinal Stenosis With and Without Low-grade Spondylolisthesis: What do Preoperative Radiographic Parameters Tell Us?

Study Design. Retrospective single-center cohort study. Objective. The aim of this study was to analyze the influence of preoperative radiographic parameters on reoperation rates after microsurgical laminotomy for lumbar spinal stenosis (LSS). Summary of Background Data. Decompression for symptomatic LSS has shown to be effective. However, the optimal surgical strategy remains a matter of debate, especially with underlying spondylolisthesis. Methods. Adult patients with LSS who underwent primary laminotomy without fusion between January 2012 and September 2013 at our institution were included for analysis. Disc height (in mm), facet joint (FJ) orientation (degrees), and grade of spondylolisthesis of all surgical index levels (SILs) were analyzed from preoperative magnetic resonance imaging. Patients were contacted in January 2017 by follow-up phone call (mean follow-up 49 months) regarding lumbar reoperation. Results. A total of 161 patients (mean age 68.5 yrs, ±11.3) and 236 SILs were analyzed. Fifty-six patients (34.8%) had low-grade spondylolisthesis involving 60 SILs (25.4%). Twenty-four patients (14.9%) underwent reoperation involving 32 levels. Of latter, 23 SILs (9.7%) had recurrent stenosis (RS) and 9 (3.8%) had adjacent level stenosis. Five patients in total (3.1%) required secondary fusion; all had preexisting spondylolisthesis. SILs with spondylolisthesis had a significantly higher rate of RS requiring reoperation compared with SILs without spondylolisthesis [18.3% (11/60) vs. 6.8% (12/176), P = 0.013]. Disc height and FJ orientation showed no significant difference between patients with and without reoperation, or with and without spondylolisthesis. Conclusion. Decompression alone is reasonable for most patients with LSS and stable low-grade spondylolisthesis. The overall reoperation rate and need for secondary fusion were low in our series. However, patients with spondylolisthesis had a higher rate of reoperation for RS after laminotomy without fusion. This must be taken into account for preoperative risk-benefit analysis, tailored surgical decision making and patient counseling. Level of Evidence: 4
Hydrolytic Hydrogen Production on Al–Sn–Zn Alloys Processed by High-Pressure Torsion

Aluminium-tin-based alloys with different compositions were synthesized by a high-pressure torsion (HPT) method. The effect of different alloying elements and processing routes on the hydrogen generation performance of the alloys was investigated. The results show that Zn can enhance the hydrogen generation rate and yield by promoting pitting corrosion. The highest reactivity in water was achieved for an Al-30wt %Sn-10wt %Zn alloy. Detailed analysis of the Al-30wt %Sn-10wt %Zn alloy shows that increasing the shear strain and the resultant formation of ultrafine grains and phase mixing enhance the hydrogen generation rate through the effects of both nanogalvanic cells and pitting corrosion.
Insights into bacterial lipoprotein trafficking from a structure of LolA bound to the LolC periplasmic domain

Significance The outer membrane of Gram-negative bacteria presents a selectively permeable barrier to the environment and is the first line of defense against antibiotics and other antimicrobial agents. Maintenance of the outer membrane relies on lipoproteins delivered by the LolABCDE system, making the Lol proteins attractive targets for the development of new antimicrobial compounds. During trafficking, lipoproteins are extracted from the cytoplasmic membrane by the LolCDE complex, transported across the periplasm by LolA, and integrated into the outer membrane by LolB. Here, we describe structural features underpinning the interaction between LolA and LolCDE. The structure of LolA bound to the periplasmic domain of LolC provides an arresting molecular snapshot of a key intermediate in the bacterial lipoprotein trafficking pathway. In Gram-negative bacteria, outer-membrane lipoproteins are essential for maintaining cellular integrity, transporting nutrients, establishing infections, and promoting the formation of biofilms. The LolCDE ABC transporter, LolA chaperone, and LolB outer-membrane receptor form an essential system for transporting newly matured lipoproteins from the outer leaflet of the cytoplasmic membrane to the innermost leaflet of the outer membrane. Here, we present a crystal structure of LolA in complex with the periplasmic domain of LolC. The structure reveals how a solvent-exposed β-hairpin loop (termed the “Hook”) and trio of surface residues (the “Pad”) of LolC are essential for recruiting LolA from the periplasm and priming it to receive lipoproteins. Experiments with purified LolCDE complex demonstrate that association with LolA is independent of nucleotide binding and hydrolysis, and homology models based on the MacB ABC transporter predict that LolA recruitment takes place at a periplasmic site located at least 50 Å from the inner membrane. Implications for the mechanism of lipoprotein extraction and transfer are discussed. The LolA–LolC structure provides atomic details on a key protein interaction within the Lol pathway and constitutes a vital step toward the complete molecular understanding of this important system.
Impact of the International Nosocomial Infection Control Consortium (INICC) multidimensional approach on rates of ventilator-associated pneumonia in intensive care units of two hospitals in Kuwait

Objective: To analyse the impact of the International Nosocomial Infection Control Consortium (INICC) multidimensional approach (IMA) on ventilator-associated pneumonia (VAP) rates in three intensive care units (ICUs) from two hospitals in Kuwait City from January 2014 to March 2015. Design: A prospective, before–after study on 2507 adult ICU patients. During baseline, we performed outcome surveillance of VAP applying CDC/NHSN definitions. During intervention, we implemented the IMA through the INICC Surveillance Online System (ISOS), which included: (1) a bundle of infection prevention interventions; (2) education; (3) outcome surveillance; and (4) feedback on VAP rates and consequences. Logistic regression analysis was performed to estimate the effect of the intervention on VAP, controlling for potential bias. Results: During baseline, 1990 mechanical ventilator (MV)-days and 14 VAPs were recorded, accounting for 7.0 VAPs per 1000 MV-days. During intervention, 9786 MV-days and 35 VAPs were recorded, accounting for 3.0 VAPs per 1000 MV-days. The VAP rate was reduced by 57.1% (incidence-density ratio = 0.51; 95% CI = 0.28–0.93; p = 0.042). Logistic regression showed a significant reduction in VAP rate during the intervention phase (OR = 0.39, 95% CI = 0.18–0.83), with 61% effectiveness. Conclusions: Implementing IMA through ISOS was associated with a significant reduction in the VAP rate in Kuwait ICUs.
Induction heating-selection of frequency

Discussion and author's closure of paper 44–166 by N. R. Stansel, presented at the AIEE summer technical meeting, St. Louis, Mo. , June 26–30, 1944, and published in AIEE TRANSACTIONS, 1944, October section, pages 755–9.
Changing Trends in Etiology‐Based and Ethnicity‐Based Annual Mortality Rates of Cirrhosis and Hepatocellular Carcinoma in the United States

With recent improvements in the treatment of end‐stage liver disease (ESLD), a better understanding of the burden of cirrhosis and hepatocellular carcinoma (HCC) is needed in the United States. A population‐based study using the US Census and national mortality database was performed. We identified the age‐standardized etiology‐specific mortality rates for cirrhosis and HCC among US adults ages 20 years or older from 2007 to 2016. We determined temporal mortality rate patterns by joinpoint analysis with estimates of annual percentage change (APC). Age‐standardized cirrhosis‐related mortality rates increased from 19.77/100,000 persons in 2007 to 23.67 in 2016 with an annual increase of 2.3% (95% confidence interval [CI] 2.0‐2.7). The APC in mortality rates for hepatitis C virus (HCV)‐cirrhosis shifted from a 2.9% increase per year during 2007 to 2014 to a 6.5% decline per year during 2014 to 2016. Meanwhile, mortality for cirrhosis from alcoholic liver disease (ALD, APC 4.5%) and NAFLD (APC 15.4%) increased over the same period, whereas mortality for hepatitis B virus (HBV)‐cirrhosis decreased with an average APC of −1.1%. HCC‐related mortality increased from 3.48/100,000 persons in 2007 to 4.41 in 2016 at an annual rate of 2.0% (95% CI 1.3‐2.6). Etiology‐specific mortality rates of HCC were largely consistent with cirrhosis‐related mortality. Minority populations had a higher burden of HCC‐related mortality. Conclusion: Cirrhosis‐related and HCC‐related mortality rates increased between 2007 and 2016 in the United States. However, mortality rates in HCV‐cirrhosis demonstrated a significant decline from 2014 to 2016, during the direct‐acting antiviral era. Mortality rates for ALD/NAFLD‐cirrhosis and HCC have continued to increase, whereas HBV‐cirrhosis‐related mortality declined during the 10‐year period. Importantly, minorities had a disproportionately higher burden of ESLD‐related mortality.
Families Created by Egg Donation: Parent–Child Relationship Quality in Infancy

Increasing numbers of children are being born through egg donation and thus do not share a genetic relationship with their mother. Parent–infant relationship quality was examined in 85 egg donation families and a comparison group of 65 in vitro fertilization families (infant M = 11 months). Standardized interview and observational measures were used to assess mother–infant and father–infant relationship quality at the representational and behavioral levels. Few differences were found between family types in parents’ representations of the parent–infant relationship. Differences were found between family types in the observational assessment of mother–infant relationship quality, indicating less optimal interactions in egg donation families. Findings suggest that egg donation families function well in infancy overall, but there may be subtle yet meaningful differences in mother–infant interaction quality.
Design Principles of Flux-Switch Alternators [includes discussion]

The general problem of the design of a peak-power minimum-volume high-frequency alternator which employs the flux-switch principle is discussed. Included in this paper are analyses of general configuration, generated voltage and frequency, magnetic circuit, generator losses, and materials. A design procedure which employs the use of a set of empirically derived constants which determine various mechanical and electrical parameters is presented. The design charts can be used for flux-switch alternators ranging in power from 100 to 5,000 watts and for shaft speeds from 10,000 to 50,000 rpm. A sample design based on the use of the design charts is developed for a 50,000-rpm 3-kw 250-volt single-phase flux-switch alternator with permanent magnet excitation.
Time-Dependent Pressure Effect in Liquid Dielectrics

The electric strengths of n hexane and transformer oil have been measured at various pressures using linearly rising voltages having rates of rise between 50 kV/cm/¿s and 20 MV/ cm/¿s. Each measurement was made by applying a single pulse of sufficient magnitude to ensure breakdown in order to avoid the possible influence of prestressing with the normal multipulse technique. For both liquids the electric strengths are strongly dependent on the rate of rise of the applied field and on hydrostatic pressure, but the pressure dependence diminishes with increasing rate of rise of the applied field, and at rates of rise higher than about 4 MV/cm/¿s the pressure dependence practically disappears. The results indicate that a certain time may be required for bubbles to form and deform in an electrically stressed liquid and that the bubble mechanism may not be operative in the breakdown process for fast-rising voltages.