Miracle-dz/UniFAR-FTUs huggingface dataset:
The phonological awareness abilities of children with cerebral palsy who do not speak

To investigate the importance of the connection between being able to speak and the emergence of phonological awareness abilities, the performance of children with cerebral palsy (five speakers and six non-speakers) was assessed at syllable, onset-rime, and phoneme levels. The children were matched with control groups of children for non-verbal intelligence. No group differences were found for the identification of syllables, reading non-words, or judging spoken rhyme. The children with cerebral palsy who could speak, however, performed better than the children with cerebral palsy who could not speak and the control group of children without disabilities, judging written words for rhyme. The children with cerebral palsy who could not speak performed poorly in comparison to those who could speak (but not the control group of children) when segmenting syllables and on the phoneme manipulation task. The findings suggest that non-speaking children with cerebral palsy have phonological awareness performance that varies according to the mental processing demands of the task. The ability to speak facilitates performance when phonological awareness tasks (written rhyme judgment, syllable segmentation, and phoneme manipulation) require the use of an articulatory loop.
Effects of atrazine on fathead minnow in a short‐term reproduction assay

Atrazine is the most extensively used herbicide in the United States. Part‐per‐million concentrations of atrazine have been reported in agricultural runoff. It is detectable in surface waters and precipitation throughout the year, and it has been found in groundwater sources of drinking water. Recent studies indicate that atrazine may be a potent endocrine‐disrupting compound in frogs exposed to part‐per‐billion (μg/L) concentrations. For these reasons, the effects of atrazine (5 and 50 μg/L) on several endpoints related to reproductive fitness were examined in fathead minnows (Pimephales promelas) in a 21‐d static exposure. Estradiol (0.5 μg/L) was included as a positive‐control treatment. Endpoints examined in adult fish during and after the exposures included survival, egg production, number of spawns, eggs/spawn, relative gonad weight, gonad histology, number of nuptial tubercles, and plasma vitellogenin concentration. Eggs produced during the exposures were hatched and reared in control water. The percentages of embryos fertilized and hatched as well as larval survival were evaluated. Decreasing trends were observed in relative testis weight, testis maturity, and percentage embryo fertilization. These trends suggest that further investigation is warranted, but the differences in these and other endpoints were not statistically significant in the atrazine‐exposed fish. Nearly all endpoints concerning fish exposed to estradiol were significantly different from atrazine‐exposed fish and control fish. These results suggest that atrazine did not have strong estrogenic effects in adult fathead minnows and did not cause overt reproductive toxicity at environmentally relevant concentrations.
IL-33 Markedly Activates Murine Eosinophils by an NF-κB–Dependent Mechanism Differentially Dependent upon an IL-4–Driven Autoinflammatory Loop

Eosinophils are major effector cells in type 2 inflammatory responses and become activated in response to IL-4 and IL-33, yet the molecular mechanisms and cooperative interaction between these cytokines remain unclear. Our objective was to investigate the molecular mechanism and cooperation of IL-4 and IL-33 in eosinophil activation. Eosinophils derived from bone marrow or isolated from Il5-transgenic mice were activated in the presence of IL-4 or IL-33 for 1 or 4 h, and the transcriptome was analyzed by RNA sequencing. The candidate genes were validated by quantitative PCR and ELISA. We demonstrated that murine-cultured eosinophils respond to IL-4 and IL-33 by phosphorylation of STAT-6 and NF-κB, respectively. RNA sequence analysis of murine-cultured eosinophils indicated that IL-33 induced 519 genes, whereas IL-4 induced only 28 genes, including 19 IL-33–regulated genes. Interestingly, IL-33 induced eosinophil activation via two distinct mechanisms, IL-4 independent and IL-4 secretion/autostimulation dependent. Anti–IL-4 or anti–IL-4Rα Ab-treated cultured and mature eosinophils, as well as Il4- or Stat6-deficient cultured eosinophils, had attenuated protein secretion of a subset of IL-33–induced genes, including Retnla and Ccl17. Additionally, IL-33 induced the rapid release of preformed IL-4 protein from eosinophils by a NF-κB–dependent mechanism. However, the induction of most IL-33–regulated transcripts (e.g., Il6 and Il13) was IL-4 independent and blocked by NF-κB inhibition. In conclusion, we have identified a novel activation pathway in murine eosinophils that is induced by IL-33 and differentially dependent upon an IL-4 auto-amplification loop.
Influence of blood pressure on tolerance to an intracranial expanding mass

ABSTRACT – In 3 groups of 4 dogs with normotensive, induced‐hypotensive and induced‐hypertensive blood pressure respectively, continuous expansion of an extradural supratentorial balloon led to respiratory arrest at inflation volumes which increased with increasing blood pressure. This positive correlation between the volume tolerance to an expanding lesion and blood pressure was also found in similar experiments on 4 hypotensive and 4 hypertensive cats.
Dynamic response of murine gut intraepithelial T cells after infection by the coccidian parasite Eimeria

The response of murine intraepithelial lymphocyte (IEL) populations to challenge by Eimeria vermiformis, a naturally occurring protozoan parasite of the gut epithelium, has been studied. The number of recoverable IEL increased within 3 days post infection, was depleted by day 7 post infection, but was significantly increased again by about day 14 post infection. Special attention was paid to γ δ+ IEL T cells, because they are of unknown functions. These cells showed changes in numbers similar to the total IEL population. Moreover, by day 3, increased expression was detected among γ δ + IEL T cells, of T cell receptor genes not constitutively associated with the intestine. These results demonstrate that the IEL repertoire, and within that, the γ δ + T cell repertoire, can be extremely dynamic post infection with a naturally occurring epithelial‐tropic pathogen. In considering the potential benefits of such IEL changes, we hypothesize that they may be relevant to the transient protection of the host's epithelium, both from parasitic re‐infection, and from potentially damaging inflammation.
Evaluating Oncology Value-Based Frameworks in the U.S. Marketplace and Challenges in Real-World Application: A Multiple Myeloma Test Case

BACKGROUND: With the continuous rise in costs for oncology drugs, the American Society of Clinical Oncology (ASCO), the Institute for Clinical and Economic Review (ICER), the Memorial Sloan Kettering Cancer Center’s Drug Abacus (DrugAbacus), and the National Comprehensive Cancer Network (NCCN) have developed value-based frameworks (VBFs) to assist stakeholders in formulary and treatment decision-making processes. Since emerging VBFs have the potential to affect available treatment options for patients, it is important to understand the differences associated with these VBFs within various therapeutic areas. OBJECTIVES: To (a) compare VBFs across 3 therapeutic options for relapsed or refractory multiple myeloma (RRMM) and (b) identify challenges and limitations associated with real-world decision making using VBFs in the U.S. marketplace. METHODS: The values of regimens carfilzomib (CFZ), elotuzumab (ELO), and ixazomib (IX) were generated using the ASCO, NCCN, ICER, and DrugAbacus VBFs. These regimens, used for second- or third-line treatment of RRMM, shared a common comparator in clinical trials: lenalidomide + dexamethasone (LEN + DEX). ASCO’s 2016 VBF, which incorporated clinical benefit, toxicity, and bonus points, was used to generate a net health benefit score, along with the drug wholesale acquisition cost, for each regimen compared with LEN + DEX. Results of the 2016 NCCN Evidence Blocks for multiple myeloma and the ICER 2016 report of treatment options for RRMM were extracted to generate the value of CFZ, ELO, and IX. No output was generated from DrugAbacus because of the lack of regimens included in the test case. Shortcomings associated with running the test case in RRMM for each VBF were also identified. RESULTS: Among the 3 therapeutic agents, CFZ, in combination with LEN + DEX, was the most valued. ASCO and ICER VBFs suggested that CFZ + LEN + DEX may be the most valued, followed by ELO + LEN + DEX and IX + LEN + DEX. NCCN suggested that LEN + DEX may be the most valued followed by CFZ + LEN + DEX, IX + LEN + DEX, and ELO + LEN + DEX. A number of shortcomings were noted across each VBF, such as complexities of drug evidence evaluation with the ASCO VBF, the inability to adjust the ICER and NCCN VBFs to specific populations, and subjectivity associated with the NCCN VBF and DrugAbacus. CONCLUSIONS: Although the test case provided some consensus on treatment decisions, there is much nuance and limitations with the VBFs available for RRMM. Clearer objectivity and better adaptability to specific treatment decisions are warranted.
Orientation of US Young Adults toward E-cigarettes and their Use in Public.

OBJECTIVES We examined use of e-cigarettes and views toward their use in public. METHODS An online survey of US adults aged 18-24 (N = 874) was used. Measures included tobacco/e-cigarette use, acceptability of public cigarette/e-cigarette use, intention to use e-cigarettes, attitudes and norms. RESULTS There was greater acceptance of public e-cigarette use than cigarettes. A path model revealed that attitudes and norms concerning e-cigarettes predicted the use of e-cigarettes beyond the effect of smoking. Attitudes also were shown to predict intention for future e-cigarette use above the effect of current and past smoking, and to predict acceptability of public use of e-cigarettes. CONCLUSIONS Normative acceptance of e-smoking in public may contribute to the wider adoption of e-cigarettes.
Year : 2010 Transcranial magnetic stimulation in depression-- lessons from the multicentre trials

Since various studies, including multi-centre studies, investigating the effect of repetitive transcranial magnetic stimulation (rTMS) in depression have shown different results, it is now important to research, which symptoms of depression are most responsive to this kind of non-invasive brain stimulation. Furthermore, an increasing interest of rTMS as a potential tool for treatment of neurological and psychiatric disorders should be recorded. Therefore, it is critical to investigate dopaminergic functional interactions in the prefrontal cortex, and in particular, the effect of dorsolateral prefrontal cortex stimulation on clinical symptoms depending on dopaminergic concentrations in various brain regions. This short review summarizes important preliminary data, which focus on the symptom-oriented effects of rTMS in depression.
The Rising Burden of Preeclampsia in the United States Impacts Both Maternal and Child Health

Abstract Objective Preeclampsia is one of the top six causes of maternal mortality in the United States (US) and is associated with considerable perinatal morbidity and mortality. Evidence suggests the US incidence of preeclampsia has increased dramatically over the past two decades. This study aims to compile, summarize, and critique the literature on the health and economic burden of preeclampsia and early-onset preeclampsia. Study Design We reviewed the literature for estimates of burden of preeclampsia and early-onset preeclampsia to both mother and child, summarized the evidence on economic and social burden, and highlighted current gaps in the literature. Results No recent studies comprehensively assess the costs and health consequences of preeclampsia or early-onset preeclampsia for both mother and child. Where it exists, the literature suggests preeclampsia and early-onset preeclampsia cause numerous adverse health consequences, but these conditions currently lack effective treatment. The need for preterm delivery from early-onset preeclampsia suggests its costs are substantial: very (28–31 weeks) and extremely (<28 weeks) preterm birth cost approximately 40 and 100 times a term pregnancy, respectively. Conclusion Given the severity of outcomes from preeclampsia, further research on its health and economic consequences is essential to inform policy and resource allocation decisions in health care.
Adapalene–benzoyl peroxide, a unique fixed‐dose combination topical gel for the treatment of acne vulgaris: a transatlantic, randomized, double‐blind, controlled study in 1670 patients

Background Combination therapy utilizing agents with complementary mechanisms of action is recommended by acne guidelines to help simultaneously target multiple pathogenic factors. A unique, topical, fixed‐dose combination gel with adapalene 0·1% and benzoyl peroxide (BPO) 2·5% has recently been developed for the once‐daily treatment of acne.
Aesthetic Considerations in Nasal Reconstruction and the Role of Modified Nasal Subunits

&NA; In 1985, Burget and Menick's landmark article on the nasal subunit principle popularized the technique of reconstructing the specific topographic subunits that they identified as the dorsum, tip, and columella and the paired alae, sidewalls, and soft triangles. In patients with more than 50 percent of subunit loss, Burget and Menick proposed removing the remaining portion of the subunit and reconstructing the entire subunit with a skin graft or flap. They further supported the placement of incisions for local flaps along borders of aesthetic subunits to maximize scar camouflage. Although the concept of nasal subunits is important in planning the reconstruction, other aesthetic considerations, such as skin texture, color, contour, and actinic damage, are also crucial in achieving an optimal result. Often, focusing on these aspects with the goal of nasal symmetry in mind leads to the violation of the subunit principle but provides a pleasing result of both the defect and the donor site. The purpose of this study was to demonstrate when and how the modification of the nasal subunit principle is used to achieve coverage of nasal skin defects. A retrospective analysis of patients who underwent nasal reconstruction after skin cancer ablation surgery by one surgeon at the Hospital of the University of Pennsylvania from 1987 to 2000 was performed. During this 13‐year period, 219 patients underwent 245 nasal reconstructions. Seventy‐four patients with 76 reconstructions (31 percent) had procedures that violated the classic nasal subunit principle. Eight of these 74 patients (11 percent) had complications, and eight (11 percent) had 10 revisions performed. The aesthetic and functional results were graded as excellent, good, and fair. The results for the 74 patients who underwent modification of the subunit were excellent in 85 percent, good in 13 percent, and fair in 2 percent. Case reports were selected to illustrate situations in which the nasal subunit was altered. (Plast. Reconstr. Surg. 111: 639, 2003.)
A Varactor-Tunable High Impedance Surface With a Resistive-Lumped-Element Biasing Grid

A high impedance surface consisting of metallic square patches electrically connected through vias to the ground plane beneath them is made tunable. Tunability is achieved by connecting adjacent patches with varactor diodes thus altering the capacitance between the patches and hence the surface's resonance frequency. The varactor diodes are biased with the aid of a resistive grid. The grid is made resistive using surface mount resistors. Using an approximate equivalent circuit the effect of the varactor diode resistance is investigated for normal plane wave incidence. It is shown that at resonance, a small varactor resistance may lead to a significant absorption. The potential use of a waveguide simulator to characterize approximately the performance of the proposed metamaterial structure is investigated.
Resistance of Type 5 chemical protective clothing against nanometric airborne particles: Behavior of seams and zipper

ABSTRACT In the field of dermal protection, the use of chemical protective clothing (CPC) (including coveralls) are considered as the last barrier against airborne engineered nanomaterials (ENM). In the majority of cases, Type 5 CPC, used against solid particles (ISO 13982-1), perform well against ENM. But in a recent study, a penetration level (PL) of up to 8.5% of polydisperse sodium chloride airborne nanoparticles has been measured. Moreover, in all the previous studies, tests were performed on a sample of protective clothing material without seams or zippers. Thus, the potential for permeation through a zipper or seams has not yet been determined, even though these areas would be privileged entry points for airborne ENM. This work was designed to evaluate the PL of airborne ENM through coveralls and specifically the PL through the seams on different parts of the CPC and the zipper. Eight current models of CPC (Type 5) were selected. The samples were taken from places with and without seams and with a zipper. In some cases, a cover strip can be added to the zipper to enhance its sealing. Polydisperse nanoparticles were generated by nebulization of a sodium chloride solution. A penetration cell was developed to expose the sample to airborne nanometric particles. The NaCl particle concentration in number was measured with an ultrafine particle counter and the PL was defined as the downstream concentration divided by the upstream concentration. The results obtained show that the PL increased significantly in the presence of seams and could reach up to 90% depending on the seam's design. Moreover, this study classifies the different types of seams by their resistance against airborne ENM. As for the penetration of airborne NaCl particles through the zipper, the PL was greatly attenuated by the presence of a cover strip, but only for certain models of coveralls. Finally, the values of the pressure drop were directly linked to the type of seam. All of these conclusions provide recommendations to both manufacturers and users.
Management of dislocated lens material

Posterior dislocation of lens fragments is a well-known complication of phacoemulsification. Retained lens material in the vitreous cavity can lead to poor visual acuity related to inflammation, corneal edema, and glaucoma. Pars plana vitrectomy is frequently necessary to remove the dislocated lens fragments. The optimal timing of vitrectomy has not been firmly established. Several large studies have failed to establish an association between timing of vitrectomy and visual outcome. However, others suggest that earlier vitrectomy may lead to improved visual outcomes and lower rates of chronic glaucoma. Excellent outcomes are possible for patients undergoing vitrectomy for retained lens fragments. Retinal detachment is the most common cause of poor visual acuity in these patients. The risk of retinal detachment is correlated with vitreous manipulation by the cataract surgeon in attempts to retrieve dislocated lens material. Therefore, if both the anterior segment and vitreoretinal surgeons rigorously avoid vitreous traction in these cases, a good visual prognosis is expected.
Partner smoking characteristics: Associations with smoking and quitting among blue-collar apprentices.

BACKGROUND Studies suggest that the social context of blue-collar workers contribute to their low smoking cessation rates. However, little is known on the effect of partner smoking and requests to quit on workers' cessation attempts. METHODS Using data from a longitudinal smoking cessation intervention, multivariable logistic regression models were constructed to investigate the association of partner smoking characteristics with cessation among blue-collar apprentices. RESULTS Smokers were more likely to have partners who smoke (OR 13.06; 95% CI 8.52-20.01). Partner's request to quit was associated with higher odds of smoking cessation at 1 month (OR 3.74; 95% CI 2.49-5.63) and 6 months (OR 1.90; 95% CI 1.06-3.41) post-intervention. Having a partner who smoked was associated with lower odds of smoking cessation at 1 month (OR 0.41; 95% CI 0.27-0.62), but not 6 months post-intervention. CONCLUSIONS Results suggest that smoking cessation interventions that include partner support might improve cessation among blue-collar smokers.
Therapeutic potential of highly cytotoxic natural killer cells for gastric cancer

To develop more effective therapies for patients with advanced gastric cancer, we examined the potential of ex vivo expanded natural killer (NK) cells. We assessed the expression of ligands for NK Group 2 Member D (NKG2D, an important NK activation molecule) in primary tumors from 102 patients with gastric cancer by immunohistochemistry and determined their prognostic value. We then examined the in vitro and in vivo cytotoxicity of NK cells from healthy donors and patients with gastric cancer. The cytotoxicity of resting and of interleukin (IL)‐2‐activated NK cells was compared to that of NK cells expanded for 7 days by coculture with the K562‐mb15‐4.1BBL cell line. As a result, the expression of NKG2D ligands in primary tumors was correlated with favorable presenting features and outcomes, suggesting that gastric cancer may be sensitive to NK cell cytotoxicity. Although resting NK cells showed minimal cytotoxicity against gastric cancer cells, K562‐mb15‐4.1BBL‐expanded NK cells were highly cytotoxic and significantly more powerful than IL‐2‐activated NK cells. Cytotoxicity was correlated with NKG2D ligand expression and could be modulated by mitogen‐activated protein kinase and AKT‐PI3 kinase inhibitors. The cytotoxicity of expanded NK cells against HER2‐positive gastric cancer cells could be increased by Herceptin and further augmented by Lapatinib. Finally, expanded NK cells exhibited strong antitumor activity in immunodeficient mice engrafted with a gastric cancer cell line. In conclusion, gastric cancer tumors express NKG2D ligands and are highly susceptible to killing by NK cells stimulated by K562‐mb15‐4.1BBL. These results provide a strong rationale for clinical testing of these NK cells in patients and suggest their use to augment the effects of antibody therapy.
A critique of the Principal-Agent theory as applied to the design of engineering contracts

Incentives are widely used in construction contracts to incentivise the contractor to reduce construction cost. The optimal risk-sharing rate suggested by the Principal-Agent theory has been influential in shaping project investors' choice of incentive intensity. However, this theory is deficient due to failure to acknowledge the role of contract breakup cost. Based on the Principal-Agent theory, this research develops a model of construction procurement with the aim of demonstrating that failing to consider contract breakup hazards might lead project investors to offload too much risk onto the contractor. The intrinsic problem of under-pricing of risks in the Principal-Agent model makes it crucial for us to start seeking a new theoretical foundation, whereby risk-bearing capacity can be accommodated into contract design.
A microwave miniaturized linearizer using a parallel diode

A miniaturized linearizer using a parallel diode has been developed. It is composed of a parallel diode and a resistance for d.c. bias feed. The linearizer utilizes a nonlinear resistive element of the diode. In this paper, the operation principle of the linearizer is described. The parallel diode provides a high temperature stability and readiness of bias voltage adjustment. BY applying this linearizer to an S-band power amplifier, an improvement of ACP of 5 dB and power added efficiency of 8.5% has been achieved for the /spl pi//4-shift QPSK modulated signal.