Miracle-dz/UniFAR-FTUs huggingface dataset:
Uncovering the Gender Agenda - The Impacts of Fair Trade on Gender Relations in Chile

Neoliberalism has perpetuated social inequality on a global scale. Augusto Pinochet’s neoliberal experiment would have significant repercussions on Chilean society. The evolution of export agriculture propelled Chile to economic success; a pioneer for the Latin American region. Unfortunately, macroeconomic advancements did not correlate to improvements in social equality. Fair trade, an alternative economic model, emerged in response to these growing inequalities. The movement promotes a more equitable distribution of wealth, despite operating within the neoliberal economy. Furthermore, the movement represents a promise of improved livelihoods to the producers and communities which have been marginalised by the predominant neoliberal system. The application of fair trade across Latin America has been extensive. In response to increased consumer demands, the range and volume of fair trade initiatives has continued to flourish. Chilean fair trade has demonstrated incredible potential through promoting improvements in labour conditions and community development. Furthermore, the low numbers of fair trade participants have proven beneficial in minimising opportunities for corruption. However, a lack of awareness has remained the largest barrier to future fair trade expansion in Chile. One of the most significant, yet controversial consequences of the export evolution was the emergence of the temporera labour force. Despite associations with severe labour abuses, temporera employment has improved significantly over the past thirty years. The temporeras of El Palqui have attributed these remarkable improvements to increased government support and union representation. Unfortunately, gender inequality continues to plague Chile, both within agriculture and on a national scale. Fair trades clauses on gender equality have demonstrated incredible potential to influence and improve gender relations in Chile. Collaboration between fair trade, alternative ethical trading initiatives, civil society and government appears to be particularly promising. Cooperation between these institutions holds the potential to transform opportunities for female exploitation into opportunities for their empowerment.
Whole Genome, Whole Population Sequencing Reveals That Loss of Signaling Networks Is the Major Adaptive Strategy in a Constant Environment

Molecular signaling networks are ubiquitous across life and likely evolved to allow organisms to sense and respond to environmental change in dynamic environments. Few examples exist regarding the dispensability of signaling networks, and it remains unclear whether they are an essential feature of a highly adapted biological system. Here, we show that signaling network function carries a fitness cost in yeast evolving in a constant environment. We performed whole-genome, whole-population Illumina sequencing on replicate evolution experiments and find the major theme of adaptive evolution in a constant environment is the disruption of signaling networks responsible for regulating the response to environmental perturbations. Over half of all identified mutations occurred in three major signaling networks that regulate growth control: glucose signaling, Ras/cAMP/PKA and HOG. This results in a loss of environmental sensitivity that is reproducible across experiments. However, adaptive clones show reduced viability under starvation conditions, demonstrating an evolutionary tradeoff. These mutations are beneficial in an environment with a constant and predictable nutrient supply, likely because they result in constitutive growth, but reduce fitness in an environment where nutrient supply is not constant. Our results are a clear example of the myopic nature of evolution: a loss of environmental sensitivity in a constant environment is adaptive in the short term, but maladaptive should the environment change.
Can adults adequately convert alpha-linolenic acid (18:3n-3) to eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3)?

A diet including 2-3 portions of fatty fish per week, which corresponds to the intake of 1.25 g EPA (20:5n-3) + DHA (22:6n-3) per day, has been officially recommended on the basis of epidemiological findings showing a beneficial role of these n-3 long-chain PUFA in the prevention of cardiovascular and inflammatory diseases. The parent fatty acid ALA (18:3n-3), found in vegetable oils such as flaxseed or rapeseed oil, is used by the human organism partly as a source of energy, partly as a precursor of the metabolites, but the degree of conversion appears to be unreliable and restricted. More specifically, most studies in humans have shown that whereas a certain, though restricted, conversion of high doses of ALA to EPA occurs, conversion to DHA is severely restricted. The use of ALA labelled with radioisotopes suggested that with a background diet high in saturated fat conversion to long-chain metabolites is approximately 6% for EPA and 3.8% for DHA. With a diet rich in n-6 PUFA, conversion is reduced by 40 to 50%. It is thus reasonable to observe an n-6/n-3 PUFA ratio not exceeding 4-6. Restricted conversion to DHA may be critical since evidence has been increasing that this long-chain metabolite has an autonomous function, e.g. in the brain, retina and spermatozoa where it is the most prominent fatty acid. In neonates deficiency is associated with visual impairment, abnormalities in the electroretinogram and delayed cognitive development. In adults the potential role of DHA in neurological function still needs to be investigated in depth. Regarding cardiovascular risk factors DHA has been shown to reduce triglyceride concentrations. These findings indicate that future attention will have to focus on the adequate provision of DHA which can reliably be achieved only with the supply of the preformed long-chain metabolite.
Leveraging Big Data Analytics to Improve Quality of Care in Healthcare Organizations: A Configurational Perspective

Big data analytics (BDA) is beneficial for organizations, yet implementing BDA to leverage profitability is fundamental challenge confronting practitioners. Although prior research has explored the impact that BDA has on business growth, there is a lack of research that explains the full complexity of BDA implementations. Examination of how and under what conditions BDA achieves organizational performance from a holistic perspective is absent from the existing literature. Extending the theoretical perspective from the traditional views (e.g. resource-based theory) to configuration theory, the authors have developed a conceptual model of BDA success that aims to investigate how BDA capabilities interact with complementary organizational resources and organizational capabilities in multiple configuration solutions leading to higher quality of care in healthcare organizations. To test this model, the authors use fuzzy-set qualitative comparative analysis to analyse multi-source data acquired from a survey and databases maintained by the Centres for Medicare & Medicaid Services. The findings suggest that BDA, when given alone, is not sufficient in achieving the outcome, but is a synergy effect in which BDA capabilities and analytical personnel's skills together with organizational resources and capabilities as supportive role can improve average excess readmission rates and patient satisfaction in healthcare organizations.
Triennial Lactation Symposium: A local affair: How the mammary gland adapts to changes in milking frequency.

Regular removal of milk from the mammary gland is critical to maintaining milk secretion. Early studies in rodents demonstrated that changes in milking frequency influenced mammary blood flow, as well as mammary cell number and activity. Later studies in ruminants confirmed those observations and that the response was regulated locally within the mammary gland. In addition, it was discovered that increased milking frequency (IMF) during early lactation stimulated an increase in milk production that partially persisted through late lactation, indicating long-term effects on mammary function. The local mechanisms regulating the mammary response to IMF are poorly understood, although several have been proposed. To gain insight into the mechanisms underlying the mammary response to IMF, and to identify genes associated with the response, we used a functional genomics approach and conducted experiments on dairy cows exposed to unilateral frequent milking [UFM; twice daily milking (2X) of the left udder half and 4-times daily milking (4X) of the right udder half]. Across multiple experiments, we were unable to detect an effect of UFM on mammary cell proliferation or apoptosis. We have, however, identified distinct transcriptional signatures associated with the mammary response to milk removal and to UFM during early lactation. Sequential sampling of mammary tissue revealed that when UFM was imposed during early lactation, at least 2 sets of genes were coordinately regulated with changes in differential milk production of 4X vs. 2X udder halves. Moreover, some genes were persistently differentially expressed in 4X vs. 2X udder halves after UFM and were associated with the persistent increase in milk yield. We conclude that a coordinated transcriptional response is associated with the increase in milk yield elicited by IMF during early lactation and that the 2 sets of differentially expressed genes may be a marker for the autocrine up-regulation of milk production. Moreover, we propose that we have identified a novel form of imprinting associated with persistent alteration of mammary function, which we term "lactational imprinting. "
Psychosocial adjustment in children with port-wine stains and prominent ears.

OBJECTIVE To evaluate psychosocial adjustment in children with port-wine stain (PWS) and children with prominent ears (PE). METHOD Thirty-two children aged 7 to 16 years with facial PWS and 42 children with PE were evaluated using the Harter Self-Perception Profile, the Revised Children's Manifest Anxiety Scale, the Children's Depression Inventory, the Disfigurement Perception Scale, and the Child Behavior Checklist. Results were compared with normative data for the local population or with a control group. Profile scores were correlated with severity of the PWS or prominence of the ears. RESULTS Children with PE had poorer self-perception, higher concentration anxiety, and more internalizing and externalizing symptoms, and they were more withdrawn and had more social problems than children with PWS. The children with PWS functioned as well as or better than nondisfigured peers on measurements of psychosocial adjustment, while children with PE scored lower than nondisfigured peers on measures of self-perception and parent-rated social and attention problems. There was no correlation between degree of disfigurement and level of psychosocial adjustment. CONCLUSIONS Psychosocial adjustment varied according to the nature of the disfigurement or deformity and was unrelated to the severity of the disfigurement.
Reconstitution of a Thermostable Xylan-Degrading Enzyme Mixture from the Bacterium Caldicellulosiruptor bescii

ABSTRACT Xylose, the major constituent of xylans, as well as the side chain sugars, such as arabinose, can be metabolized by engineered yeasts into ethanol. Therefore, xylan-degrading enzymes that efficiently hydrolyze xylans will add value to cellulases used in hydrolysis of plant cell wall polysaccharides for conversion to biofuels. Heterogeneous xylan is a complex substrate, and it requires multiple enzymes to release its constituent sugars. However, the components of xylan-degrading enzymes are often individually characterized, leading to a dearth of research that analyzes synergistic actions of the components of xylan-degrading enzymes. In the present report, six genes predicted to encode components of the xylan-degrading enzymes of the thermophilic bacterium Caldicellulosiruptor bescii were expressed in Escherichia coli, and the recombinant proteins were investigated as individual enzymes and also as a xylan-degrading enzyme cocktail. Most of the component enzymes of the xylan-degrading enzyme mixture had similar optimal pH (5.5 to ∼6.5) and temperature (75 to ∼90°C), and this facilitated their investigation as an enzyme cocktail for deconstruction of xylans. The core enzymes (two endoxylanases and a β-xylosidase) exhibited high turnover numbers during catalysis, with the two endoxylanases yielding estimated k cat values of ∼8,000 and ∼4,500 s−1, respectively, on soluble wheat arabinoxylan. Addition of side chain-cleaving enzymes to the core enzymes increased depolymerization of a more complex model substrate, oat spelt xylan. The C. bescii xylan-degrading enzyme mixture effectively hydrolyzes xylan at 65 to 80°C and can serve as a basal mixture for deconstruction of xylans in bioenergy feedstock at high temperatures.
The spillover of race and racial attitudes into public opinion about climate change

ABSTRACT The relationship between racial attitudes and public opinion about climate change is examined. Public opinion data from Pew and American National Election Studies surveys are used to show that racial identification and prejudices are increasingly correlated with opinions about climate change during the Obama presidency. Results show that racial identification became a significant predictor of climate change concern following Obama’s election in 2008, and that high levels of racial resentment are strongly correlated with reduced agreement with the scientific consensus on climate change. These results offer evidence for an effect termed the spillover of racialization. This helps further explain why the public remains so polarized on climate change, given the extent to which racial grievances and identities have become entangled with elite communication about climate change and its related policies today.
Glucose-dependent Translocation of Insulin Promoter Factor-1 (IPF-1) between the Nuclear Periphery and the Nucleoplasm of Single MIN6 β-Cells*

Using laser-scanning confocal microscopy, we have monitored glucose-induced changes in the subcellular localization of insulin promoter factor-1 (IPF-1) labeled with a c-mycepitope tag. This construct trans-activated the insulin promoter in single living MIN6-β-cells as assessed by luciferase-based promoter analysis. IPF-1.c-myc expression also enhanced the response of the insulin promoter to elevations in extracellular glucose concentration. In the majority (148/235, 63%) of cells maintained at low (3 mm) extracellular glucose concentration, IPF-1.c-myc immunoreactivity was confined to the nuclear periphery. Incubation of cells at stimulatory (30 mm) glucose concentrations caused a rapid redistribution of the chimera to the nucleoplasm (775/958, 81% of cells). By contrast, the irrelevant transcription factor c-Fos, tagged with either c-myc or as a chimera with luciferase, was localized exclusively to the nucleoplasm irrespective of the glucose concentration. Furthermore, IPF-1 extended with the bulky (27 kDa) enhanced green fluorescent protein (EGFP) group was confined largely to the nucleoplasm at all glucose concentrations tested and did not support trans-activation of the insulin promoter by glucose. Movement of endogenous IPF-1 from the nuclear periphery to the nucleoplasm may therefore increase the trans-activational capacity of this factor in native β-cells exposed to high extracellular glucose concentrations.
Anatomical knowledge retention in third‐year medical students prior to obstetrics and gynecology and surgery rotations

Surgical anatomy is taught early in medical school training. The literature shows that many physicians, especially surgical specialists, think that anatomical knowledge of medical students is inadequate and nesting of anatomical sciences later in the clinical curriculum may be necessary. Quantitative data concerning this perception of an anatomical knowledge deficit are lacking, as are specifics as to what content should be reinforced. This study identifies baseline areas of strength and weakness in the surgical anatomy knowledge of medical students entering surgical rotations. Third‐year medical students completed a 20–25‐question test at the beginning of the General Surgery and Obstetrics and Gynecology rotations. Knowledge of inguinal anatomy (45.3%), orientation in abdominal cavity (38.8%), colon (27.7%), and esophageal varices (12.8%) was poor. The numbers in parentheses are the percentage of questions answered correctly per topic. In comparing those scores to matched test items from this cohort as first‐year students in the anatomy course, the drop in retention overall was very significant (P = 0.009) from 86.9 to 51.5%. Students also scored lower in questions relating to pelvic organs (46.7%), urogenital development (54.0%), pulmonary development (17.8%), and pregnancy (17.8%). These data showed that indeed, knowledge of surgical anatomy is poor for medical students entering surgical clerkships. These data collected will be utilized to create interactive learning modules, aimed at improving clinically relevant anatomical knowledge retention. These modules, which will be available to students during their inpatient surgical rotations, connect basic anatomy principles to clinical cases, with the ultimate goal of closing the anatomical knowledge gap. Anat Sci Educ 7: 461–468. © 2014 American Association of Anatomists.
Explore Maximal Potential Capacity of WDM Optical Networks Using Time Domain Hybrid Modulation Technique

The recent emerging time domain hybrid modulation (TDHM) technique is considered promising because it can realize continuous adaptation between spectral efficiency and transparent reach through appropriately allocating the time slot occupancy ratios of different modulation formats in a time-division multiplexing (TDM) frame. This technique is expected to achieve more efficient spectrum utilization or higher transmission capacity than the traditional transmission technique based on discrete modulation formats. For the point-to-point transmission system, the benefit of the TDHM technique has been experimentally verified. However, its benefit from the whole network perspective has not been explored yet. In this paper, we apply the TDHM technique to the optical network to maximize its transmission capacity. To evaluate the benefit of this technique, we consider the routing and wavelength assignment problem for the TDHM-based WDM network, for which we develop an integer linear programming model and a waveplane-based heuristic algorithm to maximize the total network transmission capacity for the cases with and without network protection. For the protection case, the shared backup path protection technique is employed owing to its efficiency of spare capacity sharing and simplicity in network operation. The simulation study shows that compared to the design with discrete modulation formats, the TDHM-based approach can significantly increase the network transmission capacity.
Prelacteal Feeding of Newborns in Postconflict Timor-Leste

Objectives:The aim of the present study was to investigate the prevalence of prelacteal feeding and its associated factors in Timor-Leste using updated data from the national survey. Methods:Complex sample analysis was undertaken to account for the 2-stage cluster design of the Demographic and Health Survey 2009–2010. Backward stepwise logistic regression was conducted to ascertain factors associated with the prevalence of prelacteal feeding. Results:A total of 4821 mother–infant pairs were included in the analysis. The prevalence of prelacteal feeding was 12.3% (95% confidence interval [CI] 11.1–13.5). The most popular prelacteal food was plain water (50.7%), followed by glucose/sugar water (32.5%) and milk other than breast milk (22.7%). Older mothers (35–49 years), mothers with upper socioeconomic status, those who perceived their newborns as small size, and those residing in urban areas were approximately 1.5 times more likely to give prelacteal feeds, whereas women who followed religions other than Roman Catholic had twice the risk (adjusted odds ratio 1.98; 95% CI 1.16–3.41). Conclusions:Antenatal and postnatal counselling sessions that promote exclusive breast-feeding and discourage prelacteal feeding are needed that specifically target these vulnerable subgroups of Timorese mothers.
Steady‐state VEP responses to uncomfortable stimuli

Periodic stimuli, such as op‐art, can evoke a range of aversive sensations included in the term visual discomfort. Illusory motion effects are elicited by fixational eye movements, but the cortex might also contribute to effects of discomfort. To investigate this possibility, steady‐state visually evoked responses (SSVEPs) to contrast‐matched op‐art‐based stimuli were measured at the same time as discomfort judgements. On average, discomfort reduced with increasing spatial frequency of the pattern. In contrast, the peak amplitude of the SSVEP response was around the midrange spatial frequencies. Like the discomfort judgements, SSVEP responses to the highest spatial frequencies were lowest amplitude, but the relationship breaks down between discomfort and SSVEP for the lower spatial frequency stimuli. This was not explicable by gross eye movements as measured using the facial electrodes. There was a weak relationship between the peak SSVEP responses and discomfort judgements for some stimuli, suggesting that discomfort can be explained in part by electrophysiological responses measured at the level of the cortex. However, there is a breakdown of this relationship in the case of lower spatial frequency stimuli, which remains unexplained.
Motives of Competitive and Non-Competitive Cyclists

This study examines various motives for participating in the sport of cycling. Past research on the sport of cycling has mostly been limited to physiological studies of elite cyclists. However, research on marathon runners and triathletes reveals a long list of possible motives for participation. Approximately 1,200 male and female cyclists completed an adapted version of the Motivations of Marathoners Scales (MOMS) that measured psychological motives, physical motives, social motives, and achievement motives. As a group, cyclists endorsed goal achievement and health concerns as reasons for cycling. Parametric and nonparametric statistics revealed that male cyclists were more likely to endorse competition than female cyclists and females were more likely to endorse weight concern, affiliation, and selfesteem as reasons for cycling. Competitive cyclists were more likely than noncompetitive cyclists to endorse goal achievement, competition and recognition as reasons for cycling. Noncompetitive cyclists were more likely to endorse weight concerns and affiliation as motives. Road cyclists were more likely to endorse goal achievement and competition while mountain bikers endorsed life meaning as a motivation for cycling. Potential applications to research, coaching, and training in the sport of cycling are discussed.