Miracle-dz/UniFAR-FTUs huggingface dataset:
Phase I study of short-time oxaliplatin, capecitabine and epirubicin (EXE) as first line therapy in patients with non-resectable gastric cancer

A phase I trial of short-time oxaliplatin (E), capecitabine (X) and epirubicin (E) for patients with metastatic gastric cancer was initiated to establish the recommended dose for further therapy with short-time EXE. Patients received out-patient therapy with a fixed dose of epirubicin 50 mg/m2 day 1; escalating doses of capecitabine (1 000 to 1 250 mg/m2/day continuously) and escalating doses of oxaliplatin (85 to 130 mg/m2 day 1 as a 30 minutes infusion). Cycles were repeated every 21 days for a maximum of 8 cycles. From June 2003 to June 2004, 31 patients were treated. Median age was 61 years (39–75 years), and median performance status was 0 (0–2). At level 3, one of six patients developed DLT and at dose level 4, two of six patients developed DLT (both patients had grade 4 hematological toxicities) and thus further dose escalation was not attempted. Median number of cycles was 6 (1–8), median survival was 9.2 months and median TTP was 7.5 months. A combination of epirubicin 50 mg/m2 day 1, capecitabine 1 000 mg/m2 continuously and oxaliplatin 130 mg/m2 day 1 each 3 weeks is an easily administered and well tolerated out-patient regimen for patients with non-resectable gastric cancer.
Leaf roof — designing luminescent solar concentrating PV roof tiles

The Leaf Roof project on the design features of PV roof tiles using Luminescent Solar Concentrator (LSC) technology [1] has resulted in a functional prototype. The results are presented in the context of industrial product design with a focus on the aesthetic aspects of LSCs [2]. This paper outlines the design of Leaf Roof tiles under consideration of simulation results, experimental measurements on dyes' absorption spectra, and the energy performance of Leaf Roof elements in the context of their geometry and colors.
HÉTÉROGÉNÉITÉ ET RÉUSSITE DANS LE PREMIER CYCLE UNIVERSITAIRE.

Confrontees a la forte croissance des effectifs, les universites ont d'abord ete preoccupees par les problemes d'accueil et par une necessaire adaptation quantitative de l'offre de formation. Les bilans evaluatifs, le suivi des parcours universitaires des etudiants, l'etude de leur devenir a la sortie du premier cycle n'ont pas manque d'interroger. Devant les difficultes progressivement identifiees, l'amelioration des dispositifs de formation et des conditions d'etude par un meilleur accompagnement pedagogique est aujourd'hui l'une des preoccupations majeures.
Implication of methodological uncertainties for Mid-Holocene sea surface temperature reconstructions

Abstract. We present and examine a multi-sensor global compilation of mid-Holocene (MH) sea surface temperatures (SST), based on Mg/Ca and alkenone palaeothermometry and reconstructions obtained using planktonic foraminifera and organic-walled dinoflagellate cyst census counts. We assess the uncertainties originating from using different methodologies and evaluate the potential of MH SST reconstructions as a benchmark for climate-model simulations. The comparison between different analytical approaches (time frame, baseline climate) shows the choice of time window for the MH has a negligible effect on the reconstructed SST pattern, but the choice of baseline climate affects both the magnitude and spatial pattern of the reconstructed SSTs. Comparison of the SST reconstructions made using different sensors shows significant discrepancies at a regional scale, with uncertainties often exceeding the reconstructed SST anomaly. Apparent patterns in SST may largely be a reflection of the use of different sensors in different regions. Overall, the uncertainties associated with the SST reconstructions are generally larger than the MH anomalies. Thus, the SST data currently available cannot serve as a target for benchmarking model simulations. Further evaluations of potential subsurface and/or seasonal artifacts that may contribute to obscure the MH SST reconstructions are urgently needed to provide reliable benchmarks for model evaluations.
MR İle İncelenen Lomber Disklerdeki Difüzyon Değerlerinin Dejenerasyonla Ve Yaşla Olan Ilişkisi

Amac: Bu calismada lomber disklerdeki difuzyon degerlerinin dejenerasyonla ve yasla olan iliskisi ADC olcumleriyle degerlendirildi. Gerec ve Yontem: Bel agrisi yakinmasiyla basvuran yaslari 14-64 arasinda degisen 50 olguya (24 kadin, 26 erkek) difuzyon agirlikli MR goruntuleme uygulandi. T2 agirlikli sagital goruntulerde dejenere diskler belirlendi. Dejenere diskler hafif ve agir olarak gruplandirildi. Her bir disk duzeyi icin ADC degerleri olculdu. Normal disklerin ortalama ADC degerlerinin anatomik duzeyle ve yasla olan iliskisi degerlendirildi. Dejenere disklerin ortalama ADC degerleri normal disklerle karsilastirildi. Bulgular Mann Whitney testi, Kruskal Wallis testi ve Sperman’s korelasyon katsayisiyla analiz edildi. Bulgular: Ortalama ADC degerleri normal disklerde 1.82 ± 0.20 x 10-3 mm2/sn, dejenere disklerde 1.30 ± 0.47 x 10-3 mm2/sn olarak bulundu (p< 0.01). Normal disklerde anatomik duzeyle ortalama ADC degerleri arasinda anlamli iliski saptanmadi. Yasla ortalama ADC degerleri arasinda negatif korelasyon yonunden anlamli iliski mevcuttu. Sonuc: Dejenere disklerin ADC degerleri normal disklere gore belirgin olarak azalmistir. Dejeneratif disk hastaliginin degerlendirilmesinde difuzyon MR goruntuleme son derece faydali bir yontem olabilir.
Highlights of a Position Statement: Physical Activity and Fitness Recommendations for Physical Activity Professionals

Position Statement: Participation in regular physical activity at a level sufficient to promote healthrelated physical fitness is an essential behavior for professionals in all fields of physical activity at all levels (this includes coaches, K-12 teachers, physical education and kinesiology faculty in higher education, fitness professionals, athletes, all advocates of physically active lifestyles).
Evaluation of the effect of topical agents on radiation‐induced skin disease by reflectance spectrophotometry

Objectives Radiotherapy may cause severe skin changes that significantly interfere with the patient's quality of life and reduce radiotherapy effectiveness. Many skin care instructions and various topical agents are recommended to help patients in the management of radiation skin reactions, but evidence to support the value of the topical treatments of the irradiated skin is lacking. In the present study we investigated the effects of topical agents used as supportive care to minimise radiation‐induced skin disease using an instrumental method.
PRENATAL TESTOSTERONE, PERSONALITY, AND ECONOMIC BEHAVIOR

Unconditional altruism is an enduring puzzle for evolutionary approaches to social behavior. In this paper we argue that costly signaling theory, a well-established framework in biology and economics, may be useful to shed light on the individual differences in human unconditional altruism. Based on costly signaling theory, we propose and show that unconditional altruistic behavior is related to general intelligence. The cost incurred by engaging in unconditional altruism is lower for highly intelligent people than for less intelligent people because they may expect to regain the drained resources. As a result, unconditional altruism can serve as an honest signal of intelligence. Our findings imply that distinguishing altruistic behavior from cooperative behavior in social psychological and economic theories of human behavior might be useful, and that costly signaling theory may provide novel insights on various individual difference variables. 2 This manuscript is adapted from Millet, K. , & Dewitte, S. (2007). Altruistic behavior as a costly signal of general intelligence. Journal of Research in Personality, 41, 316-326.
Efficient Online Learning via Randomized Rounding

Most online algorithms used in machine learning today are based on variants of mirror descent or follow-the-leader. In this paper, we present an online algorithm based on a completely different approach, which combines "random playout" and randomized rounding of loss subgradients. As an application of our approach, we provide the first computationally efficient online algorithm for collaborative filtering with trace-norm constrained matrices. As a second application, we solve an open question linking batch learning and transductive online learning.
Parametric GLRT for Multichannel Adaptive Signal Detection

We consider herein the problem of detecting a multichannel signal in the presence of spatially and temporally colored disturbance. A parametric generalized likelihood ratio test (GLRT) is developed by modeling the disturbance as a multichannel autoregressive (AR) process. The parametric GLRT differs from Kelly's widely known GLRT which does not utilize any parametric model for the disturbance signal. Maximum likelihood (ML) parameter estimation underlying the parametric GLRT is examined. It is shown that the ML estimator for the alternative hypothesis is non-linear and there exists no closed-form expression. An alternative asymptotic ML (AML) estimator is presented, which yields asymptotically optimum parameter estimates at a reduced complexity. The performance of the parametric GLRT is studied by considering challenging cases with limited or no training signals for parameter estimation. Such cases (especially when training is unavailable) are of great interest in detecting signals in heterogeneous, fast changing, or dense-target environments. Compared with the recently introduced parametric adaptive matched filter (PAMF) and parametric Rao detectors, the parametric GLRT achieves higher data efficiency, offering improved detection performance in general
Magnetic Properties of Nanocrystalline and Amorphous FeCoC Thin Films

FeCoC thin films are prepared by reactive sputtering. Acetylene (C 2H2) gas is introduced to control the C composition in the films by adjusting the acetylene partial pressure (P acetylene/PAr). According to X-ray diffractometry and transmission electron microscopy results, the microstructure of the films changes from well crystalline to nanocrystalline and even to amorphous with the increase of acetylene partial pressure. Results show that the value of the saturation flux density (4piMs) decreases slowly from 24.5 to 23.5 kG with the increase of acetylene partial pressure (P2H2/PAr) from 0% to 1%. The 4pi Ms decreases dramatically with acetylene partial pressure higher than 1%. Coercivity in both the hard axis and easy axis directions shows minimums around the acetylene partial pressure of 1%. H ch and Hce as low as 1.3 Oe have been obtained at the same acetylene partial pressure. The above results can be explained by the measurement of internal stress and magnetostriction. All the films show compressive stress. However, the stress shows a minimum, about 0.2times10-9 dyne/cm2 with the acetylene partial pressure of 1%, and it increases dramatically for acetylene partial pressure higher than 1%
The power of a pebble: exploring and mapping directed graphs

Exploring and mapping an unknown environment is a fundamental problem that is studied in a variety of contexts. Many results have focused on finding efficient solutions to restricted versions of the problem. In this paper, we consider a model that makes very limited assumptions about the environment and solve the mapping problem in this general setting. We model the environment by an unknown directed graph G, and consider the problem of a robot exploring and mapping G. The edges emanating from each vertex are numbered from ‘1’ to ‘d’, but we do not assume that the vertices of G are labeled. Since the robot has no way of distinguishing between vertices, it has no hope of succeeding unless it is given some means of distinguishing between vertices. For this reason we provide the robot with a “pebble”—a device that it can place on a vertex and use to identify the vertex later. In this paper we show: (1) If the robot knows an upper bound on the number of vertices then it can learn the graph efficiently with only one pebble. (2) If the robot does not know an upper bound on the number of vertices n, then (log log n) pebbles are both necessary and sufficient. In both cases our algorithms are deterministic. C © 2002 Elsevier Science (USA)
ELDRS in Bipolar Linear Circuits: A Review

Enhanced Low Dose Rate Sensitivity (ELDRS) in bipolar linear transistors was first identified in bipolar microcircuit transistors in 1991 and demonstrated in bipolar linear circuits in 1994. Since then it has been a major topic of research, characterization and analysis. Data compendia of low dose rate enhancement factors were presented in 1996, 2001 and 2008, identifying 30 unique widely used circuit types as susceptible to ELDRS. Early work on ELDRS was directed toward identifying mechanisms, characterizing circuits and developing hardness assurance methods, concentrating on accelerated testing techniques. More recently the research on ELDRS has focused on the effects of pre-irradiation elevated temperature stress (PETS), final passivation layers and molecular hydrogen in the package. This review paper provides an update on ELDRS in bipolar linear circuits, including the most recent results of mechanisms research, and the effects of post metallization processing on the total ionizing dose response.
Time determination of BGO-APD detectors by digital signal processing for positron emission tomography

Coincidence timing resolution in positron emission tomography (PET) can be improved by replacing fast analog pulse shaping and constant fraction discriminator (CFD) with fully digital signal processing. This can be achieved by digitizing the signal from individual detectors using 100-MHz 8-bit analog-to-digital converters (ADC) and processing the data in field programmable gate arrays (FPGA). Various digital implementation of filters and baseline restorers have been combined with numerical least mean square fit to the data to extract the time of interaction and the energy deposited in BGOAPD detectors. Using the same detector and pre-amplifier, a time resolution of 7.2 ns was obtained with digital techniques, as compare to 12.7 ns with the conventional analog method. By reducing the BGO-BGO coincidence time window by more than /spl sim/40 %, an equivalent reduction of the rate of random events can be obtained, which would improve image SNR significantly at high counting rate in a BGO-APD PET scanner. The proposed digital techniques can be readily adapted to other faster detectors.
NUTRITION OF THE HOST AND NATURAL RESISTANCE TO INFECTION

The property of a diet of whole wheat and whole dried milk to promote a higher survival rate among a stock of heterogenetic, outbred W-Swiss mice subjected to S. enteritidis infection, over that promoted by a "synthetic" diet, has been shown to be a function of the infecting bacterial population. Broth cultures so prepared as presumably to yield S. enteritidis organisms of uniform character have consistently failed to reveal an effect of diet on natural resistance, even though the parent bacterial populations revealed a dietary effect. The dietary difference effect on natural resistance could not be demonstrated with an avirulent culture of S. typhimurium, or with a freshly prepared virulent culture of S. typhimurium presumably uniform in character. The dietary effect on natural resistance was demonstrated by employing a 1:1 mixture of avirulent and virulent cultures of S. typhimurium.
How Does Anxiety Influence Maths Performance and What Can We do About It

How Does Anxiety Influence Maths Performance and What Can We do About It? Volume/Issue Vol 6, Issue 4 Date Wednesday, 1 November, 2006 Journal Name MSOR Connections Author(s) David Sheffield Thomas Hunt Abstract Maths anxiety has been the focus of much psychological and educational research in the past few years. In this article, we review some of this research evidence and describe some of the work we have completed. In particular, we will describe what maths anxiety is and how it has been measured, describe some of the consequences of maths anxiety, and finally describe what can be done to alleviate difficulties associated with math anxiety. DOI doi:10.11120/msor.2006. 06040019 File upload msor.6. 4e.pdf [1] Taxonomy: work area Journals [2]
Distributed MPC-Based Secondary Voltage Control Scheme for Autonomous Droop-Controlled Microgrids

In this study, we propose a novel distributed secondary control scheme for both voltage and frequency in autonomous microgrids. By incorporating predictive mechanisms into distributed generations, the secondary voltage control is converted to a tracker consensus problem of distributed model predictive control, with the synchronous convergence procedure for voltage magnitudes to the reference value drastically accelerated at a low communication cost. A sufficient local stability condition with the parameter analysis is established. Thus, a distributed proportional integral method combined with a finite-time observer to estimate the global reference information is presented in the frequency restoration while maintaining accurate active power sharing. Our approach accommodates model uncertainty, plug-and-play capability, and especially robustness against information update intervals, which is essential when the conventional method probably yields toward a poor performance. Meanwhile, the distributed architecture implemented on the local and neighboring information allows for a sparse communication network and eliminates the requirement for a centralized controller. Simulation results are provided to verify the effectiveness of the proposed control methodology.
Are COX-2 Selective NSAIDs Associated with Less GI, Renal, and Cardiovascular Side Effects: Evidence from Animals Treated with NSAIDs

Aims: Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used to treat both acute and chronic pain in animals, especially when the pain is resulted from inflammatory conditions. NSAIDs work by inhibition of cyclooxygenases (COX) enzymes and reduce the production of key inflammatory mediators prostaglandins and associated chemicals. Prostaglandins have important roles in pain signalling and haemostasis, including platelet aggregation and gastric mucosal protection. There are two known isoforms of cyclooxygenases enzymes, namely COX-1 and COX2. Notable adverse effects commonly resulted from NSAIDs uses include gastrointestinal ulceration, compromised haemostasis and renal toxicity, which are due to inhibition of COX-1 isoform. Despite the development of COX-2 selective medicines and continuing effort to improve the safety of NSAIDs in routine veterinary practice, adverse effects of NSAIDs still exist and require closed monitoring. This study aims to summarise and evaluate the current literature on reported adverse effects of NSAIDs used in animals and to compare COX-2 selective versus non-selective agents. Methodology: Literature on reported adverse effects of NSAIDs used in animals over the last Review Article Ngo and Addison; ARRB, 29(6): 1-8, 2018; Article no.ARRB. 45152 2 decade has been systematically reviewed. Some older sources from the primary literature search have also been included to determine the background information leading to current rationale behind NSAIDs’ therapeutic uses, dosage and route of administration, observed adverse effects and COX-2 selective versus non-selective agents. The primary focus of this study is NSAIDs administered to animals in prospective randomised placebo-controlled blinded trials. Results: A total of 12 studies that met the inclusion criteria were included in the review, with total 13 NSAIDs being discussed, including meloxicam, phenylbutazone, deracoxib, carprofen, aspirin, firocoxib, vedaprofen, etorolac, ketoprofen, tepoxalin, rofecoxib, licofelone and flunixin. It was found that there were variable findings in comparing the adverse effects associated with COX-2 selective NSAIDs and non-selective NSAIDs. COX-2 selective NSAIDs have been found associated with no adverse effects in some studies and minimal adverse effects in other studies. Severe adverse effects were reported for COX-2 selective NSAID administered at higher than recommended doses or for a long duration and some studies reported reduced adverse effects in COX-2 selective NSAIDs when compared to non-selective NSAIDs. Overall, gastrointestinal adverse effects were predominantly reported, followed by adverse findings relating to haemostasis and renal function. Conclusion: Collectively, the findings suggest COX-2 selective NSAIDs provide a clinically useful improvement over non-selective NSAIDs as well as reduce adverse effects when given at recommended dose.
The use of dexamethasone in animals: implication for fertility, pregnancy and extrapolation of the animal data to humans

Exposure to dexamethasone causes numerous changes in various biological systems including the reproductive system and this has huge implication on fertility and pregnancy. Maternal dexamethasone administration promotes foetal lung maturation and thermoregulation in premature foetuses. This indication makes dexamethasone a drug of choice in maternal and neonatal human and veterinary health care. In addition, dexamethasone is widely used in human and veterinary medicine as potent anti-inflammatory, immunosuppressive and analgesic drug in all age categories. Although the safety profile of short term dexamethasone treatment has been established, there has been growing concern about the long term effects of dexamethasone therapy and its implication on fertility and pregnancy in animals and humans. Most of the indications or uses in humans are extrapolated from animal data. This necessitates the need to provide review updates of current literature on dexamethasone use in humans and animals as there are many intrinsic differences between humans and animals. The review provides an overview of dexamethasone uses, its merits and demerits on animal pregnancy and fertility and implication on extrapolation of the animal data to humans. The review is based on a comprehensive literature search of relevant materials between 1969 and 2016 as well as authors’ personal manuscript/abstract files and citations of known references and discussed according to the multidisciplinary clinical experience of the authors. Although low-dose dexamethasone treatment has been used in veterinary and human clinics for many years and produced no severe effect on vital functions, repetitive high dose or long-term therapy may be associated with more serious sequelae on fertility and pregnancy. While no animal truly recapitulates human pregnancy and fertility, it is recommended that results from animal data be subjected to rigorous preclinical pharmacokinetic scaling processes to justify possible extrapolation to humans.