Miracle-dz/UniFAR-FTUs huggingface dataset:
Towards a New Model of Leadership for the NHS

This paper was commissioned by the NHS Leadership Academy as a contribution to thinking about the future development of leadership in and around the NHS. It was prepared in collaboration with the Hay Group. The backdrop and one of the triggers was the launch of a new suite of professional development programmes sponsored and organised by the NHS Leadership Academy. From the research reported in this paper a new framework for leadership in the healthcare is built. This is being used to guide the construction of a new Leadership Model. To quote the NLA this 'will be a well-researched, evidence-based model that reflects the values of the NHS, what we know about effective leadership, what we have learned from the Leadership Framework and what our patients and communities are now asking from us as leaders'.
Prognostic impact of high c-Met expression in ovarian cancer: a meta-analysis

High c-Met expression has been observed in epithelial ovarian cancer (EOC). However, its clinicopathological impacts remain controversial. We conducted this meta-analysis to evaluate the pathologic and prognostic significance of c-Met overexpression in patients with EOC. A systematic computerized search of the electronic databases PubMed, PMC, EMBASE, and Google scholar (up to April 2018) was carried out. From seven studies, 568 patients with EOC were included in the meta-analysis. Although there was no statistical significance, EOCs with c-Met overexpression tended to show higher FIGO stage (III-IV) (odds ratio = 2.18, 95% confidence interval: 0.86-5.53, p = 0.10) and higher rate of lymph node metastasis (odds ratio = 3.05, 95% confidence interval: 0.85-10.98, p = 0.09), compared with tumors with low c-Met expression. In terms of prognosis, patients with c-Met-high EOC showed significantly worse survival than those with c-Met-low tumor (hazard ratio = 2.11, 95% confidence interval: 1.51-2.94, p < 0.0001). In conclusion, this meta-analysis indicates that high c-Met expression represents an adverse prognostic marker for patients with EOC.
Edge and divertor plasma: detachment, stability, and plasma-wall interactions

The paper presents an overview of the results of studies on a wide range of the edge plasma related issues. The rollover of the plasma flux to the target during progressing detachment process is shown to be caused by the increase of the impurity radiation loss and volumetric plasma recombination, whereas the ion-neutral friction, although important for establishing the necessary edge plasma conditions, does not contribute per se to the rollover of the plasma flux to the target. The processes limiting the power loss by impurity radiation are discussed and a simple estimate of this limit is obtained. Different mechanisms of meso-scale thermal instabilities driven by impurity radiation and resulting in self-sustained oscillations in the edge plasma are identified. An impact of sheared magnetic field on the dynamics of the blobs and ELM filaments playing an important role in the edge and SOL plasma transport is discussed. Trapping of He, which is an intrinsic impurity for the fusion plasmas, in the plasma-facing tungsten material is considered. A newly developed model, accounting for the generation of additional He traps caused by He bubble growth, fits all the available experimental data on the layer of nano-bubbles observed in W under irradiation by low energy He plasma.
Red wine phenolic composition: the effects of summer pruning and cluster thinning

P.M. Canon, A.S. Gonzalez, J.A. Alcalde, and E. Bordeu. 2014. Red wine phenolic composition: the effects of summer pruning and cluster thinning. Cien. Inv. Agr. 41(2): 235-248. The quality of red wine is directly associated with its phenolic composition, which can be controlled using several viticultural techniques that affect the vegetative/productive balance of the plants, such as summer pruning and cluster thinning. However, these techniques may also involve high costs and production losses. This study aimed to evaluate the effects of summer pruning and cluster thinning on the phenolic compositions of grapes and wine over three consecutive seasons. The treatments included long (120 cm shoot length) and short (60 cm shoot length) summer pruning and 50% cluster thinning with control treatments conducted in vineyards with cvs. Cabernet-Sauvignon and Carmenere and located in a warm area (Cachapoal, Chile) and cvs. Cabernet-Sauvignon and Pinot Noir located in a cold area (Casablanca, Chile). These treatments generated differences in the microclimatic conditions (radiation and temperature) and the vegetative/productive balance of the plants. Depending on whether the grapevine vigor was high or low, short summer pruning increased or decreased the phenolic composition. The effects of cluster thinning varied according to the natural productivity of each season, increasing the phenolic composition when the natural yields were high and producing no significant effects when they were low. The decision to make these viticultural practices to improve the phenolic composition of the wine depends on the seasonal vineyard vigor and potential productivity. Thus, measures are only applied when a severe imbalance in the vegetative/productive equilibrium occurs or when the microclimatic conditions of the vineyard must be improved.
The Association between Attitude towards the Implementation of Staff Development Training and the Practice of Knowledge Sharing among Lecturers.

This study was aimed to identify the association of teachers’ attitude towards the implementation of Staff Development Training with Knowledge Sharing Practices among the lecturers of the Teacher Training Instituition (TTI). In addition, this study was also to examine the differences in attitudes towards the implementation of Staff Development Training and differences of knowledge sharing practices of lecturers based on demographic factors (gender, teaching experience, and academic qualifications). This is a quantitative approach in cross-sectional survey to collect data on the attitude towards staff development training and knowledge sharing practices among lecturers. The population of this study involved 748 lecturers from TTI in Perlis, Kedah, and Pulau Pinang. Stratified random sampling technique was used to select 336 samples from the population. The instruments used in this research were Attitude of Staff Development Training (Siti-Zanariah, 2010) and Knowledge Sharing (Siti-Zanariah, 2010). Statistical Package for Social Science (SPSS) Version 19.0 was used for analysis of data. The descriptive data analysis involved the description of the respondents such as frequency and percentage, while the second part of inferential analysis was to test the hypotheses, using Pearson correlation, t-test, and ANOVA. This study had found that there was a significant and positive association between attitude towards SDT with knowledge sharing practices, a significant difference and positive attitude towards SDT based on gender and teaching experience and a significant and positive difference in terms of knowledge sharing practices based on gender, teaching experience, and academic qualifications. However, the results revealed that there were no significant differences in the attitudes of SDT based on academic qualifications. This research also discussed about the findings, implications, and contributions to the body of knowledge and the country, as well as the direction of future research.
A study of qualitative dermatoglyphics in patients suffering from essential hypertension

Aims and Objective: To compare the dermatoglyphics in patients suffering from essential hypertension with that of normal persons. Introduction: Dermatoglyphics is a branch of genetic dealing with the skin ridge system. Through the years of research dermatoglyphics has immerged as a powerful tool in the diagnosis of psychological, medical and genetic condition. Diagnosis of Diabetes Mellitus Schizophernia, Hypertensionetc can now be aided by dermatoglyphicanalysis. This study is undertaken because the dermatoglyphics and essential hypertension both have Genetic basis. Methodology: The present study was carried out in 60 patients of essential hypertension and 60 normal individuals in Medical College and normal individuals were obtained from Master colony, and the study variables were analyzed using Chi-Square test. Result: The presence of arches is more in Patients as compared to Controls but this is not statistically significant (X = 0.06 P>0.05). The overall percentage frequency of Radial Loops were more in Patients as compared to controls but this difference was not statistically significant (χ=2.69; df = 2; P>0.05). The overall percentage and frequency of Ulnar Loops were less in Patients as compared to controls which is statistically significant (χ=15.47; df=2; P<0.05). The overall Frequency and percentage of whorls were more in Patients as compared to controls which is not significant (χ=2.37; df=2; P>0.05). Conclusion: Ulnar loop frequency showed significant decrease in patients of essential hypertension as compared to controls.
The Dynamics of Terrorist Networks: Understanding the Survival Mechanisms of Global Salafi Jihad

Today terrorists usually work in network forms to conduct attacks. Terrorist networks remain active and can still function even after being severely damaged by authorities. Analyzing terrorist networks from a dynamic point of view can provide insights about the mechanisms responsible for the survival of terrorist organizations. This paper studies the dynamics of a major international terrorist organization over a 14-year period  the Global Salafi Jihad (GSJ) terrorist network. We found that a scale-free topology gradually emerged as new members joined the GSJ network based on operational needs. In addition, since the network has been experiencing member losses while it grows, we also studied the robustness of the GSJ network. We used a simulation approach to examine its vulnerability to random failures, targeted attacks, and real world authorities' counterattacks. We found that authorities' counterattacks have been rather ineffective in disrupting the terrorist network.
Melatonin Effects on EEG Activity During Sleep Onset in Mild-to-Moderate Alzheimer’s Disease: A Pilot Study

There is evidence demonstrating that 5-mg of fast-release melatonin significantly reduces nocturnal sleep onset in patients with mild-to-moderate Alzheimer’s disease (AD). However, the physiological mechanism that could promote sleep installation by melatonin in patients with AD is still poorly understood. The present pilot study was designed to analyze the effects of melatonin on cortical activity during the sleep onset period (SOP) in eight mild-to-moderate AD patients treated with 5-mg of fast-release melatonin. Electroencephalographic recordings were obtained from C3-A1, C4-A2, F7-T3, F8-T4, F3-F4, and O1-O2. The relative power (RP), interhemispheric, intrahemispheric, and fronto-posterior correlations of six electroencephalographic bands were calculated and compared between two conditions: placebo and melatonin. Results show that at F7-T3, F3-F4, and C3-A1, melatonin induced an increase of the RP of the delta band. Likewise, in F7-T3, melatonin induced a decrease of the RP in the alpha1 band. Similarly, results show a lower interhemispheric correlation between the F7-T3 and F8-T4 derivations in the alpha1 band compared to the placebo condition. We conclude that the short sleep onset related to melatonin intake in AD patients was associated with a lower RP of the alpha1, a higher RP of the delta band (mainly in the left hemisphere) and a decreased interhemispheric EEG coupling in the alpha1 band. The possible role of the GABAergic neurotransmission as well as of the cascade of neurochemical events that melatonin triggers on sleep onset are discussed.
A genetic variant in interleukin 8-251 A / T is associated with the risk of clear cell renal cell carcinoma in Chinese population

Background: Interleukin-8 (IL-8) is an angiogenic chemokine that plays a potent role in both development and progression of many human malignancies. However, there are no data about the role of IL-8 polymorphism in development of RCC. Patients and methods: A hospital-based case-control study was conducted among 520 patients with RCC and 520 healthy controls to investigate the possible association between the IL-8-251A/T and +781C/T polymorphisms respectively, and the risk of RCC. Results: Significant differences of genotype distribution were observed between RCC cases and controls at the IL-8-251T/A genotypes. Compared with the IL-8-251T/A homozygote TT, the heterozygous TA genotype was associated with significantly increased risk for RCC (OR = 1.83, 95% CI = 1.23-3.95, P = 0.019); the AA genotype was associated with increased risk for RCC (OR = 1.88, 95% CI = 1.29-3.68, P = 0.015). TA and AA combined variants were associated with increased risk for RCC compared with the TT genotype (OR = 1.85, 95% CI = 1.24-3.81, P = 0.018). Moreover, the genotype AA of IL-8-251T/A carried a higher risk of RCC metastasis and later stages, compared with the TT genotype. However, the genotype and allele frequencies of IL-8+781C/T polymorphisms in RCC patients were not significantly different from controls. Conclusion: Our results showed that the IL-8-251A/T genotype was associated with increased risk for development and metastasis of RCC in Chinese Han population.
The Experimental Study of Increased ICP on Cerebral Hemorrhage Rabbits with Magnetic Induction Phase Shift Method

Introduction Measuring magnetic induction phase shift (MIPS) changes as a function of cerebral hemorrhage volume has the potential for being a simple method for primary and non-contact detection of the occurrence and progress of cerebral hemorrhage. Our previous MIPS study showed that the intracranial pressure (ICP) was used as a contrast index and found the primary correlation between MIPS and ICP. Materials and Methods In this study，we theoretically deduced the approximate relationship between MIPS and ICP and carried out a comparison study between MIPS and ICP on cerebral hemorrhage in rabbits in this study. Acute cerebral hemorrhage was induced by injecting autologous blood (3 to 6mL) into the brain of rabbits in the experimental group (n=7). Results The animal experiment results showed that the MIPS decreased significantly as a function of injection volume in the experimental group and the changes of ICP and MIPS of rabbits from experimental group presented a negative correlation. We also found that the MIPS slopes of all experimental samples had a change trend from fastness to slowness with a reverse of the change of ICP. Conclusion These observations suggested that the non-contact MIPS method might be valuable and potential for monitoring acute cerebral hemorrhage and obtaining the ICP information.
Examining the effectiveness and robustness of sequential data assimilation methods for quantification of uncertainty in hydrologic forecasting

In hydrologic modeling, state‐parameter estimation using data assimilation techniques is increasing in popularity. Several studies, using both the ensemble Kalman filter (EnKF) and the particle filter (PF) to estimate both model states and parameters have been published in recent years. Though there is increasing interest and a growing literature in this area, relatively little research has been presented to examine the effectiveness and robustness of these methods to estimate uncertainty. This study suggests that state‐parameter estimation studies need to provide a more rigorous testing of these techniques than has previously been presented. With this in mind, this paper presents a study with multiple calibration replicates and a range of performance measures to test the ability of each technique to calibrate two separate hydrologic models. The results show that the EnKF is consistently overconfident in predicting streamflow, which relates to the assumption of a Gaussian error structure. In addition, the EnKF and PF were found to perform similarly in terms of tracking the observations with an expected value, but the potential for filter divergence in the EnKF is highlighted.
Gender differences in emotional intelligence: The mediating effect of age.

Are women more emotionally intelligent than men? Today it is widely believed, among the general public and academics alike, that the female gender is linked with better knowledge of emotions. Is this notion correct or yet another stereotype? To address this question, the relationship between gender and emotional intelligence (EI), as assessed using the “Mayer-Salovey-Caruso Emotional Intelligence Test” (MSCEIT), is considered. A new perspective was taken in this research by controlling for age, which is one of the principal sociodemographic characteristics that interacts with gender as well as EI, in order to clarify how gender affects EI. Results showed that the gender differences initially reported for EI are mediated completely by age for the branches of facilitation and understanding, for strategic area and for total score, and partially by age for the dimension of emotional managing. These findings indicate the need for caution when concluding that gender affects EI in the absence of tests for possible interactions between gender and other variables that may influence EI. Resumen ? Son las mujeres mas inteligentes emocionalmente que los hombres? Actualmente sigue vigente la vision, tanto popular como academica, de que el genero femenino se vincula con un mejor conocimiento de las emociones. Es realmente cierta esta cuestion o se trata de un estereotipo mas? En este articulo consideramos la relacion entre el sexo y la inteligencia emocional (IE) evaluada con el “Test de inteligencia emocional Mayer- Salovey-Caruso” (MSCEIT), controlando la edad, como una de las principales caracteristicas sociodemograficas que inte
SAFETY PERSPECTIVES IN THIS ISSUE

In this issue we identify major differences in reports of cancer associated with drugs for psoriasis, a common skin disorder affecting an estimated 7.5 million people. While corticosteroid and other topical drugs are sufficient for many cases, potent immunosuppressant drugs are used in increasing numbers. In this report we also provide new evidence that drugs for erectile dysfunction and pulmonary arterial hypertension can cause deafness or sudden hearing loss.
Demography and Genetic Structure of a Recovering Grizzly Bear Population

Abstract Grizzly bears (brown bears; Ursus arctos) are imperiled in the southern extent of their range worldwide. The threatened population in northwestern Montana, USA, has been managed for recovery since 1975; yet, no rigorous data were available to monitor program success. We used data from a large noninvasive genetic sampling effort conducted in 2004 and 33 years of physical captures to assess abundance, distribution, and genetic health of this population. We combined data from our 3 sampling methods (hair trap, bear rub, and physical capture) to construct individual bear encounter histories for use in Huggins–Pledger closed mark–recapture models. Our population estimate, N̂ = 765 (95% CI = 715–831) was more than double the existing estimate derived from sightings of females with young. Based on our results, the estimated known, human-caused mortality rate in 2004 was 4.6% (95% CI = 4.2–4.9%), slightly above the 4% considered sustainable; however, the high proportion of female mortalities raises concern. We used location data from telemetry, confirmed sightings, and genetic sampling to estimate occupied habitat. We found that grizzly bears occupied 33,480 km2 in the Northern Continental Divide Ecosystem (NCDE) during 1994–2007, including 10,340 km2 beyond the Recovery Zone. We used factorial correspondence analysis to identify potential barriers to gene flow within this population. Our results suggested that genetic interchange recently increased in areas with low gene flow in the past; however, we also detected evidence of incipient fragmentation across the major transportation corridor in this ecosystem. Our results suggest that the NCDE population is faring better than previously thought, and they highlight the need for a more rigorous monitoring program.
Production of proinflammatory mediators by human neutrophils during long-term culture

Neutrophils, usually considered short-living cells, play a key role in several inflammatory processes contributing to disease generation and progression. The present study was devised to investigate the changes occurring during long-term culture in neutrophil functions and morphology. Neutrophils were obtained from venous blood of healthy donors and cultured up to 24 h. Levels of interleukin (IL)-8, vascular endothelial growth factor (VEGF) and elastase were analysed by real time PCR and ELISA under resting and after stimulation with fMLP, LPS and IL-8. Apoptosis was measured by flow cytometry, migration by means of microscopic evaluation, reactive oxygen species (ROS) production by means of spectrofluorometry and cell morphology using optical microscopy and transmission electron microscopy. After 24 h cell number and viability was reduced with respect to 3 h of culture and number of cells in early and late apoptosis were increased. No appreciable differences were found between mRNA levels for IL-8, VEGF and elastase at the two times. Similarly elastase protein production was unchanged while on the contrary, IL-8 and VEGF protein levels were higher after 24 h. Resting and stimulated migration were unchanged up to 24 h. Values measured for spontaneous ROS generation were superimposable for the two times, fMLP-induced ROS generation was reduced at 24 h and LPS failed to increases ROS generation after 24 h. Cell morphology was preserved up to 24 h. These results indicate that neutrophils can be studied ex vivo even in long-term colture, although timelength of the culture affects some of their functional properties.
Nutritional value of high and low tannin high-moisture sorghum grain silage in horses

The objective in this work was to determine the nutritive value of high and low tannin high-moisture sorghum grain silage in horse feeding by means of digestibility. A total of eight crossbred geldings at the age of six years and an average body weight of 330 kg were used in a complete randomized design with samples replicated on the same animals. The test-diets consisted of the ensiled high and low tannin sorghum grains replacing 30% of the dry matter of the reference diet, constituted exclusively by hay. The daily dry matter intake was equivalent to 2.0% of the body weight, so, the test diets were constituted by 30% of ensiled sorghum grains and 70% of hay. The digestibility coefficients of the nutrients of the low and high tannin sorghum grain silages were obtained by the difference between the coefficient of digestibility of the nutrients of the reference diet and the test-diets. The values of digestibility of dry matter, energy and protein of the high tannin sorghum grain silage were lower (73.65, 73.65 and 71.33%) than low tanin sorghum grain silage (87.70, 87.70 and 82.36%). The contents of digestible dry matter, digestible protein, digestible starch, digestible neutral detergent fiber and digestible energy were 59.08%, 10.63%, 71.48%, 2.32% and 3,954 Mcal/kg of dry matter of the low tannin sorghum grain silage and 50.58%, 8.16%, 67.80%, 3.72% and 3,192 Mcal/kg of the dry matter of high tannin sorghum grain silage, respectively, therefore, only contents of digestible neutral detergent fiber and starch were similar among silages. The use of low tannin sorghum grain silage, an alternative food in formulation of promising diets for horses feeding.