Miracle-dz/UniFAR-FTUs huggingface dataset:
Left ventricular performance in dogs with selective coronary embolization with mercury

Left ventricular function was studied before and after production of acute myocardial infarction by selective mercury embolization of the circumflex coronary artery in 8 closed chest dogs lightly anesthetized with morphine and chloralose. Ventricular function curves relating stroke volume, stroke work and mean stroke power to left ventricular end-diastolic pressure were determined. Stroke volume was obtained by an indicator dilution method with the heart rate kept constant by pacing. Left ventricular end-diastolic pressure was acutely increased by three 100 cc infusions of dextran before and 45 minutes after embolization. With dextran infusion before embolization, the mean right atrial pressure and the left ventricular end-diastolic pressure increased linearly; following embolization the left ventricular end-diastolic pressure increased out of proportion to the right atrial pressure. After embolization, the slope of the ventricular function curves was depressed consistently. However, the cardiac output post-embolization could be increased with dextran infusion up to a left ventricular Filling pressure of 19–20 mm Hg beyond which the curves relating output to filling pressure flattened or actually decreased. Thus, left ventricular function was measurably diminished following acute myocardial infarction in this experiment.
ANALISIS PENGARUH KEPUASAN DAN BRAND TRUST TERHADAP MINAT BELI ULANG PANTENE (STUDI PADA ‘YOUNG FEMALE’ SEMARANG)

Pantene is a shampoo well-known brand from PT. Procter & Gamble. Pantene became the market leader of category Shampoo over the last four years. But the high competition make a Brand value indexs of Pantene shampoo has decreased, which means there is a decline in the performance of the brand. It is characterized by the decline in TOM Brand, Satisfaction, and Brand Share. As a market leader Pantene need to be careful because it is an indication of decreased in repurchase Intention. This study aims to determine the effect Selebrity Endoser and quality of repurchase Intention by Brand Trust and satisfaction as an intervening variable. This study used data on 197 young female respondents aged 17-35 in the city of Semarang who had used Pantene more than twice, Thus, this study can not be generalized to the context of other studies, both gender and age. This study used six variables: Celebrity Endorser, Quality , Satisfaction, Brand Trust, and Repurchase Intention. The analysis technique used in this research is Structural Equation Model (SEM) of AMOS 22.0. Research shows that to improve repurchase intentionof Pantene to young female in Semarang can only be done through one process, namely improving the quality of Pantene that will increase satisfaction and ultimately increase Interests repurchase intention of young female in city Semarang
Finding conserved patterns in biological sequences, networks and genomes

Finding Conserved Patterns in Biological Sequences, Networks and Genomes. (December 2007) Qingwu Yang, B.S., Peking University Chair of Advisory Committee: Dr. Sing-Hoi Sze Biological patterns are widely used for identifying biologically interesting regions within macromolecules, classifying biological objects, predicting functions and studying evolution. Good pattern finding algorithms will help biologists to formulate and validate hypotheses in an attempt to obtain important insights into the complex mechanisms of living things. In this dissertation, we aim to improve and develop algorithms for five biological pattern finding problems. For the multiple sequence alignment problem, we propose an alternative formulation in which a final alignment is obtained by preserving pairwise alignments specified by edges of a given tree. In contrast with traditional NPhard formulations, our preserving alignment formulation can be solved in polynomial time without using a heuristic, while having very good accuracy. For the path matching problem, we take advantage of the linearity of the query path to reduce the problem to finding a longest weighted path in a directed acyclic graph. We can find k paths with top scores in a network from the query path in polynomial time. As many biological pathways are not linear, our graph matching approach allows a non-linear graph query to be given. Our graph matching formulation overcomes the common weakness of previous approaches that there is no guarantee on the quality of the results. For the gene cluster finding problem, we investigate a formulation based on con-
Behavioural intervention effects in dysarthria following stroke: communication effectiveness, intelligibility and dysarthria impact.

BACKGROUND Dysarthria is a common post-stroke presentation. Its management falls within the remit of the speech and language therapy profession. Little controlled evaluation of the effects of intervention for dysarthria in stroke has been reported. AIMS The study aimed to determine the effects of a period of behavioural communication intervention on communication effectiveness and intelligibility, and of the speech disorder's impact on the person with dysarthria. METHODS & PROCEDURES Eight people with dysarthria following stroke received individually tailored intervention programmes of 16 sessions during an 8-week period. Conversation, and reading aloud of connected speech and of single words were sampled at four points, at intervals of around 2 months: two before intervention and two after intervention. The data were perceptually evaluated by ten listeners, blind to assessment point, for the overall effectiveness of communication (conversation) and for single-word and reading intelligibility. The impact of dysarthria was assessed at the beginning and end of the intervention period. OUTCOME & RESULTS The level of reliability of listener ratings was high. There was no evidence of group change between assessment points for measures of communication effectiveness during conversation, or for reading and word intelligibility. Individual participant analysis indicated that five speakers improved in at least one of these three measures. In all cases this followed either stability or deterioration during the 2-month pre-intervention period. There was very little evidence of deterioration during the 2 months after withdrawal of treatment. For three participants no intervention-related speech benefit was demonstrated. Age, dysarthria severity or lesion information did not appear to differentiate those who improved from those who did not. Improvement occurred in all who began the intervention phase between 5 and 8 months following stroke onset. Group data indicated no change in the Dysarthria Impact Profile in respect of three sections (The effect of dysarthria on me as a person; How I feel others react to my speech; and How dysarthria affects my communication with others). There was a significant difference between the start and end of intervention for Accepting my dysarthria, suggesting a reduction in the negative impact of dysarthria. CONCLUSIONS The results demonstrate that some individuals with dysarthria have a capacity to respond positively to intervention, some months after stroke, and to maintain this improvement following 2 months of no intervention. Consideration is given to how the results of the present study may inform subsequent phases of dysarthria stroke research.
Effect of blood pressure on blood flow in ischemic and in nonischemic cerebral cortex

AUTOREGULATION has been defined as “the capability of an organ to regulate its blood supply in accordance with its needs. ”’ Thus, those changes in circulation or in blood flow occurring in relation to changes in functional activity, oxygen supply, carbon dioxide production, pH, or perfusion pressure of an organ and brought about by intrinsic mechanisms can be considered as types of autoregulation. The best understood and most easily studied type of autoregulation is that related to perfusion pressure. In many organs, if functional activity remains constant, blood flow likewise remains relatively constant despite moderate changes in perfusion pressure. Cerebral blood flow is influenced greatly by arterial carbon dioxide tension (Paco,). 2-5 If PacOz is constant, regional blood flow will depend largely on functional activity.B-11 If both functional activity and P%02 are relatively constant, regional and total cerebral blood flow then remain relatively constant despite changes in mean systemic arterial blood pressure.12-16 This constancy of blood flow has been ascribed to autoregulation, although the techniques commonly used to change systemic blood pressure (removal of blood or injection of drugs) may themselves be responsible for changes in the circulation, rather than mechanisms intrinsic to the brain. Anything which interferes with cerebrovascular responsivity or with the integrity of cerebral tissue can interfere with the maintenance of cerebral blood flow during changes in blood pressure; examples include trauma,13J7 marked changes in P%0z,14J6 or interference with the cervical blood vessels supplying the brain. ” There is some evidence that, in human beings, cerebral ischemia can cause impairment of constancy of blood flowlSJ9 (Fieschi, C., and Ingvar, D. H.: Unpublished data). In the series of experiments to be reported here, the maintenance of relatively constant
ICT, Search Behavior and Market Outcomes

Information and Communication Technologies (ICT) help to reduce transaction costs in several ways. The study of this phenomenon and the resulting economic consequences are the underlying common theme in the four subsequent chapters of my dissertation. Each of them is a self-contained paper that contributes to the field of Industrial Organization. In particular, I contribute to the study of two important phenomena that arose as a consequence of the ICT-enabled reduction in transaction costs, which modern societies have seen over the last two decades: electronic commerce (E-Commerce, in what follows) and (commons based) “peer production.
Expression of matrix metalloproteinase ‐2, ‐9 and tissue inhibitors of metalloproteinase ‐1, ‐2, ‐3 mRNAs in rat uterus during early pregnancy

Zymography and in situ hybridizition were used to investigate matrix metalloproteinase‐2, ‐9 (MMP‐2, ‐9) activities, and expression of mRNAs for MMP‐2, ‐9 and tissue inhibitors of matrix metalloproteinases (TIMP‐1, ‐2, ‐3) in the rat uterus during early pregnancy (day 1–7). The zymography results showed two forms of MMP‐2 (64 and 67 kDa) in the rat uteri during early pregnancy. The 64‐kDa MMP‐2 activity was the highest on day 2 (P < 0.01) and higher on day 5 and 6 (P < 0.05). The 67‐kDa MMP‐2 activity reached the highest on day 5 and 6 (P < 0.01). The 64‐kDa MMP‐2 activity at the implantation sites was higher than those at interimplantation sites (P < 0.05). Furthermore, the 67 kDa MMP‐2 can be converted to 64 kDa forms by incubation with p‐aminophenylmercuric acetate (APMA) and trypsin in vitro. The 92‐kDa MMP‐9 activity was only detected on day 5 and 6 of pregnancy (P < 0.01). In situ hybridization showed that on day 1–4 of pregnancy, both MMP‐2 and TIMP‐2 mRNAs were evidently localized in the basal stromal cells. On day 5, MMP‐2 mRNA signals were decreased in the basal stromal cells and mRNA for TIMP‐2 was expressed in the epithelial cells and subepithelial stromal cells. The mRNAs for MMP‐9, TIMP‐1, and ‐3 were mainly expressed in epithelial cells on day 1–5. At the implantation site on day 6, the mRNAs for MMP‐2, ‐9, TIMP‐1, ‐2, and ‐3 were highly expressed in the primary decidual zone surrounding the implanting embryo, and in the whole decidualized stromal cells (the primary and secondary decidual zones) at the implantation site on day 7. The intensities of mRNAs for the TIMPs in decidualized stromal cells at the implantation site on day 6 and 7 were stronger than those for the MMPs. The weak mRNAs for MMP‐2, ‐9, TIMP‐1, and ‐3 but not TIMP‐2 were also observed in the ectoplacental cone/trophoblastic cells of the implanting embryos. However, at the interimplantation sites on day 6 and 7, MMP‐2, ‐9, TIMP‐1, ‐2, and ‐3 mRNAs were weakly expressed in the epithelial cells, subepithelial stromal cells, and myometrium. The results suggested that the implanting rat embryo strongly induced MMP‐2 and ‐9 proteins and gene expression for decidulization and embryo invasion, which were strictly controlled and balanced by the simultaneous expression of TIMP‐1, ‐2 and ‐3. Mol. Reprod. Dev. 62: 149–158, 2002. © 2002 Wiley‐Liss, Inc.
Acute myeloid leukaemia (FAB AML‐M4Eo) with cryptic insertion of cbfb resulting in cbfb‐Myh11 fusion

Inv(16)(p13q22) and t(16;16)(p13;q22) are cytogenetic hallmarks of acute myelomonoblastic leukaemia, most of them associated with abnormal bone marrow eosinophils [acute myeloid leukaemia French–American–British classification M4 with eosinophilia (FAB AML‐M4Eo)] and a relatively favourable clinical course. They generate a 5′CBFB‐3′MYH11 fusion gene. However, in a few cases, although RT‐PCR identified a CBFB‐MYH11 transcript, normal karyotype and/or fluorescent in situ hybridization (FISH) analyses using commercially available probes are found. We identified a 32‐year‐old woman with AML‐M4Eo and normal karyotype and FISH results. Using two libraries of Bacterial Artificial Chromosome clones on 16p13 and 16q22, FISH analyses identified an insertion of 16q22 material in band 16p13, generating a CBFB‐MYH11 type A transcript. Although very rare, insertions should be searched for in patients with discordant cytological and cytogenetic features because of the therapeutic consequences. Copyright © 2015 John Wiley & Sons, Ltd.
The antiinflammatory mechanism of methotrexate depends on extracellular conversion of adenine nucleotides to adenosine by ecto-5'-nucleotidase: findings in a study of ecto-5'-nucleotidase gene-deficient mice.

OBJECTIVE Evidence from in vitro, in vivo, and clinical studies indicates that adenosine mediates, at least in part, the antiinflammatory effects of methotrexate (MTX), although the biochemical events involved have not been fully elucidated. This study was undertaken to investigate whether MTX exerts antiinflammatory effects in mice that lack ecto-5'-nucleotidase (ecto-5'-NT) (CD73) and are unable to convert AMP to adenosine extracellularly, in order to determine whether adenosine is generated intracellularly and transported into the extracellular space or is generated from the extracellular dephosphorylation of AMP to adenosine. METHODS Male CD73 gene-deficient mice and age-matched wild-type mice received intraperitoneal injections of saline or MTX (1 mg/kg/week) for 5 weeks. Air pouches were induced on the back by subcutaneous injection of air; 6 days later, inflammation was induced by injection of carrageenan. RESULTS Fewer leukocytes, but higher levels of tumor necrosis factor alpha (TNFalpha), accumulated in the air pouches of vehicle-treated CD73-deficient mice compared with those of wild-type mice. As expected, MTX treatment reduced the number of leukocytes and TNFalpha levels in the exudates and increased exudate adenosine concentrations in wild-type mice. In contrast, MTX did not reduce exudate leukocyte counts or TNFalpha levels or increase exudate adenosine levels in CD73-deficient mice. CONCLUSION These results demonstrate that the antiinflammatory actions of MTX are mediated, at least in part, by increased release of adenine nucleotides that are hydrolyzed extracellularly to adenosine via an ecto-5'-NT-dependent pathway.
Characterization of residual stress levels in complementary bipolar junction transistors on (100) silicon

Residual levels of stress remaining after device fabrication have been characterized in the base and emitter regions of shallow-trench-isolated complementary npn and pnp transistors on (100) silicon utilizing uniaxial stress measurements. A residual biaxial stress of approximately 160 MPa has been found in the active regions of the npn transistors, whereas negligible residual stress is observed in the corresponding pnp transistors.
Population genomic evidence for adaptive differentiation in the Baltic Sea herring

Detecting and estimating the degree of genetic differentiation among populations of highly mobile marine fish having pelagic larval stages is challenging because their effective population sizes can be large, and thus, little genetic drift and differentiation is expected in neutral genomic sites. However, genomic sites subject to directional selection stemming from variation in local environmental conditions can still show substantial genetic differentiation, yet these signatures can be hard to detect with low‐throughput approaches. Using a pooled RAD‐seq approach, we investigated genomewide patterns of genetic variability and differentiation within and among 20 populations of Atlantic herring in the Baltic Sea (and adjacent Atlantic sites), where previous low‐throughput studies and/or studies based on few populations have found limited evidence for genetic differentiation. Stringent quality control was applied in the filtering of 1 791 254 SNPs, resulting in a final data set of 68 182 polymorphic loci. Clear differentiation was identified between Atlantic and Baltic populations in many genomic sites, while differentiation within the Baltic Sea area was weaker and geographically less structured. However, outlier analyses – whether including all populations or only those within the Baltic Sea – uncovered hundreds of directionally selected loci in which variability was associated with either salinity, temperature or both. Hence, our results support the view that although the degree of genetic differentiation among Baltic Sea herring populations is low, there are many genomic regions showing elevated divergence, apparently as a response to temperature‐ and salinity‐related natural selection. As such, the results add to the increasing evidence of local adaptation in highly mobile marine organisms, and those in the young Baltic Sea in particular.
The impact of credit ratings and CEOs’ work experience on earnings management and post-issue performance of U.S. IPOs

The IPO market is characterised by a high level of information asymmetry; thus, self-interested managers have strong incentives to overstate earnings during the IPO to inflate stock prices. Prior literature has provided evidence of earnings manipulation by managers around IPOs. If managers opportunitically manipulate earnings in the IPO year, the reported earnings will not be sustainable, and the IPO firms will exhibit negative abnormal stock returns in subsequent periods due to investors’ downward adjustment of their evaluation of the firm value. Another common phenomenon of the IPO markets is the underperformance of IPO firms in the post-issue periods, with nearly a third of issuers either failing or being acquired within five years of going public. Therefore, in this thesis, I aim to examine potential factors contributing to restraining the level of earnings management undertaken by IPO firms and improving the post-issue long-term performance. Specifically, I investigate the impact of credit ratings and CEOs’ work experience on earnings management and post-issue performance of newly listed firms. I uncover strong evidence that newly listed firms going public with a credit rating are less likely to engage in income-enhancing earnings management through both accruals and real operating activities manipulation. Moreover, while unrated IPO firms manipulate earnings to mislead investors, rated issuers tend to employ accounting discretion for informative purposes. I also study the association between CEOs’ financial experience and earnings management around IPOs and find that IPO firms with financial expert CEOs are less likely to manage earnings through accruals. Furthermore, financial expert CEOs tend to be informative in financial reporting to allow investors to properly gauge the fair value of the firm. In addition, I investigate the influence of CEOs’ specialist managerial experience on the probability of failure and survivability of IPO firms. My findings suggest that specialist CEOs enhance the ability of IPO firms to remain viable for a longer period of time. My research not only contributes to a wide range of literature on IPOs, credit ratings, earnings management and managerial attributes but also provides several practical implications for regulators in monitoring IPO firms’ financial reporting, for investors in making investment decisions, and for firms in considering relevant work experience for CEO appointment.
Impact of financial pressure on unemployed job search, job find success and job quality

Research shows that financial pressure – implied as a consequence of benefit sanctions or exhaustion – prompts the unemployed to intensify their job search. However, there is less agreement about whether that intensified job search produces better quality job outcomes. Building on Self-Determination Theory we posit that financial pressure is a controlled motivator to search for work. Controlled motivators are conducive to goal pursuit (job search activity), yet unfavorable to goal achievement (job search success and job quality). Using the HILDA longitudinal data for Australia, we are able to include direct measures of both financial pressure (cash flow problems and hardship), objective job quality (hourly pay and hours worked) as well as subjective job quality (satisfaction with pay and hours). We find that financial pressure intensifies job search without improving the job find rate and job quality outcomes if a job is secured. Interestingly, if a job is secured the unemployed who searched under financial pressure perceive the job to be of lower quality (in terms of satisfaction with pay and hours worked) even though objectively (in terms of actual pay and hours worked) it is similar to the jobs found by the unemployed who searched without financial pressure. Policy implications are discussed.
Identification of NEK3 Kinase Threonine 165 as a Novel Regulatory Phosphorylation Site That Modulates Focal Adhesion Remodeling Necessary for Breast Cancer Cell Migration*

Accumulating evidence supports a role for prolactin (PRL) in the development and progression of human breast cancer. Although PRL is an established chemoattractant for breast cancer cells, the precise molecular mechanisms of how PRL regulates breast cancer cell motility and invasion are not fully understood. PRL activates the serine/threonine kinase NEK3, which was reported to enhance breast cancer cell migration, invasion, and the actin cytoskeletal reorganization necessary for these processes. However, the specific mechanisms of NEK3 activation in response to PRL signaling have not been defined. In this report, a novel PRL-inducible regulatory phosphorylation site within the activation segment of NEK3, threonine 165 (Thr-165), was identified. Phosphorylation at NEK3 Thr-165 was found to be dependent on activation of the extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathway using both pharmacological inhibition and siRNA-mediated knockdown approaches. Strikingly, inhibition of phosphorylation at NEK3 Thr-165 by expression of a phospho-deficient mutant (NEK3-T165V) resulted in increased focal adhesion size, formation of zyxin-positive focal adhesions, and reorganization of the actin cytoskeleton into stress fibers. Concordantly, NEK3-T165V cells exhibited migratory defects. Together, these data support a modulatory role for phosphorylation at NEK3 Thr-165 in focal adhesion maturation and/or turnover to promote breast cancer cell migration.