Miracle-dz/UniFAR-FTUs huggingface dataset:
Entrepreneurial orientation

Purpose Scholarship in the entrepreneurship and marketing literatures has helped advance thinking about how health care organizations create value for companies and consumers. However, there is an ongoing need for empirical research; hence, the purpose of this paper is to examine how entrepreneurial orientation and customer orientation influence healthcare (retail pharmacy) industry performance. Design/methodology/approach Using a sample of the US retail pharmacies, the study applies partial least squares structural equation modeling to identify the direct and indirect effects of the entrepreneurial orientation constructs on company performance. The study also includes importance–performance analyses to prioritize for managers which orientations, dimensions and respective manifest items merit the most critical attention as contributors to pharmacy performance. Findings We find that the entrepreneurial orientation has a significant impact on customer orientation and company effectiveness. We also find that three dimensions – innovation, risk-taking, and proactiveness – exhibit stronger importance and performance than autonomy and competitive aggressiveness. Research limitations/implications While the present study employs data from firms of various sizes, it is limited to firms in the pharmacy industry. Although this study included established EO measures, one of the risk taking items was dropped from the final analysis. In certain research contexts, this result may or may not be consequential. Finally, this study employed nonfinancial measures for measuring performance. Using such measures is not uncommon and can offer insightful linkages to long-term organizational strategies in ways not afforded by conventional financial measures (Ittner and Larcker 2000); however, future research should, if possible, aim to capture financial and nonfinancial data. Practical implications In the dynamic healthcare environment, entrepreneurial pharmacies that have the ability to innovate, take risks and be proactive can provide superior customer orientation and hence better performance. Social implications Health care industry in general and pharmacies in particular have to be entrepreneurial to meet customer needs and hence the wellbeing of the society With the aging population and growth of complex diseases, pharmacies can provide better access to care delivery if they have entrepreneurial orientation. Originality/value In this study, partial least square modeling technique along with importance performance analysis was adopted for first time in this literature to identify key factors that contribute to EO. The findings will aid pharmacy managers to focus their initiatives on the three key dimensions to succeed in their retail pharmacy business.
Randomized Controlled Trial of Internet-Based Stress Management

This study investigated the effects of an internet-based self-help stress management program with a randomized controlled design. Of 85 participants, 26% dropped out, leaving a final sample of 63 participants with 23 in the treatment group and 40 in the waiting list control group. Treatment included applied relaxation, problem solving, time management and cognitive restructuring. All information and treatment interventions were provided via the internet. Results were evaluated with the Perceived Stress Scale and the Hospital Anxiety and Depression Scale. Improvements were seen in both groups, with greater improvements in the self-help treatment group. It is concluded that the internet can be used to provide stress management techniques and result in stress relief. However, spontaneous improvement, differential dropout rate and compliance need to be monitored in future studies.
Prodromal myeloproliferative neoplasms: The 2008 WHO classification

The concept of prodromal chronic myeloproliferative neoplasms has been endorsed by the WHO classification implicating a stepwise evolution of disease. Histology of the bone marrow (BM) and borderline to mildly expressed clinical features play a pivotal role for diagnosing prefibrotic‐early primary myelofibrosis. By lowering the platelet count for essential thrombocythemia and regarding BM morphology, early manifestations are tackled. Pre‐polycythemic stages of polycythemia vera with a low hemoglobin level at onset are diagnosed by positive JAK2V617F mutation status, a low erythropoietin value, and characteristic BM features. The revised WHO classification incorporates hematological, morphological, and moleculargenetic parameters to generate a consensus‐based working diagnosis. Am. J. Hematol. , 2010. © 2009 Wiley‐Liss, Inc.
Some integral characteristics of MRC receiver in Nakagami-m fading environment

In this paper, maximal ratio combining (MRC) technique over Nakagami–m fading channel is described and some statistical characteristics of received signal envelope are analysed. For analytical and numerical evaluation of system performance, the probability density functions (PDF) of received signal envelope after MRC are analysed like particular solutions of corresponding differential equation, while the existence of singular solution is considered and analysed under different conditions.
Weighted estimates for multilinear maximal functions and singular integral operators

El principal objetivo de esta Tesis es el estudio de desigualdades con pesos para diferentes operadores del analisis armonico en dos ambientes diferentes: los espacio de tipo homogeneo y en el contexto euclideo multilineal. La primera parte del presente trabajo se centra en el estudio de acotaciones fuertes y debiles con pesos de operadores de Calderon-Zygmund que generalizan a espacios de tipo homogeneo la situacion del espacio euclideo Rn. Nuestro objetivo es la obtencion de cotas formadas por al menos dos constantes Ap diferentes de manera que estas cotas mixtas sean estrictamente mas pequenas que las clasicas formadas por una constante. Asimismo, se generalizan desigualdades como la de John-Nirenberg y la desigualdas de Holder al reves, las cuales seran herramientas fundamentales de cara a determinar acotaciones optimas para los operadores de Calderon-Zygmund y los conmutadores de estos operadores con funciones de BMO. La segunda parte de esta monografia se centra en el estudio de las desigualdades con pesos para la funcion maximal y multilineal y operadores integrales singulares multilineales asi como la determinacion de las constantes optimas para la acotacion de dichos operadores. Con respecto al problema de determinacion de las constantes optimas para la funcion maximal multilineal, se consigue una cota mixta que mezcla la constante multiple Ap con un producto de constantes A8. Tambien se extienden total o parcialmente otros resultados en el contexto multiple de uno y dos pesos como los teoremas de S. Buckley y E. Sawyer, respectivamente. Asimismo, se establece el control en norma de los operadores multilineales de Calderon-Zygmund e integrales singuales multilineales con nucleos no suaves por operadores multilineales de tipo sparse. Como consecuencia de este resultado se deriva un analogo del teorema A2 para ambos tipos de operadores. Finalmente, se estudia la compacidad de los conmutadores de diferentes operadores con simbolos en un subespacio de BMO. Por un lado, el estudio se centra en los conmutadores de una clase de operadores bilineales que extiende el caso de los operadores de Calderon-Zygmund. Tambien se estudia el caso de los conmutadores de una familia de operadores bilineales fraccionarios mas singulares que pueden verse como la version fraccionaria de la transformada de Hilbert bilineal. Por otro lado, se estudian las clases de pesos multiples para los cuales se tiene que los conmutadores de operadores de Calderon-Zygmund bilineales son compactos en espacios de Lebesgue con pesos.
Locally recurrent prostate tumors following either radiation therapy or radical prostatectomy have changes in Ki-67 labeling index, p53 and bcl-2 immunoreactivity.

PURPOSE We compare the biological phenotype of recurrent prostatic tumors after definitive local therapy (radiation or radical prostatectomy) with that of the same tumors before treatment. MATERIALS AND METHODS Cellular proliferation (Ki-67 labeling index), p53 nuclear reactivity and bcl-2 immunoreactivity were determined in pretreatment and posttreatment tumor specimens from 13 patients with local tumor recurrence following radiation, and in 18 patients with local tumor recurrence following radical prostatectomy. RESULTS Mean Ki-67 labeling index increased approximately 2-fold in locally recurrent tumors after radiation (10.5 versus 5.6%, p=0.0008) or surgery (6.0 versus 3.2%, p=0.0025) when compared with pretreatment tumors. We noted p53 nuclear reactivity in a significantly higher proportion of recurrences than in pretreatment tumors following radiation (54 versus 8%, p=0.032) and surgery (39 versus 5%, p=0.022). Although bcl-2 immunoreactivity was also seen in a higher proportion of recurrent tumors, this difference did not reach statistical significance for either radiation or surgery. CONCLUSIONS Recurrent tumors following either radiation or surgery differ significantly from the corresponding pretreatment tumors with respect to cellular proliferation and p53 nuclear reactivity.
Stereochemistry of mephedrone neuropharmacology: enantiomer‐specific behavioural and neurochemical effects in rats

Synthetic cathinones, commonly referred to as ‘bath salts’, are a group of amphetamine‐like drugs gaining popularity worldwide. 4‐Methylmethcathinone (mephedrone, MEPH) is the most commonly abused synthetic cathinone in the UK, and exerts its effects by acting as a substrate‐type releaser at monoamine transporters. Similar to other cathinone‐related compounds, MEPH has a chiral centre and exists stably as two enantiomers: R‐mephedrone (R‐MEPH) and S‐mephedrone (S‐MEPH).
Super-high density Si quantum dot thin film utilizing a gradient Si-rich oxide multilayer structure

A gradient Si-rich oxide multilayer (GSRO-ML) deposition structure is proposed to achieve super-high density Si quantum dot (QD) thin film formation while preserving QD size controllability for better photovoltaic properties. Our results indicate that the Si QD thin film using a GSRO-ML structure can efficiently increase the QD density and control the QD size. Its optical properties clearly promise the capability of effective bandgap engineering even though these QDs are closely formed. The Si QD thin film using a GSRO-ML structure obviously reveals better electro-optical properties than those using a [silicon dioxide/silicon-rich oxide] multilayer ([SiO2/SRO]-ML) structure owing to the better optical absorption and carrier transport properties. Therefore, we successfully demonstrate that our proposed GSRO-ML structure has great potential for application in solar cells integrating Si QD thin films.
How does household characteristics influence their waste management

The amount of waste generated is ever-increasing due to population growth, however adequate waste management has never been a focus in everyday life. The action of the household as the beginning stage of waste management is also crucial. How households manage their waste is also influenced by their socio-economic characteristics. This study aims to investigate household characteristics that influence their waste management. This study employed the Indonesian Family Life Survey 2014 data using probit regression method. The result shows that location significantly affect waste management behaviour which households in urban areas hold higher probability to manage their waste compared to those in rural areas. The level of education and knowledge also have positive impact on household’s waste management. The level of income also positively affect waste management behaviour of households. Demographic variables such as age and gender are significant and indicate that women and older people have better waste management compared to men and younger people. These results support the hypothesis that household’s waste management behaviour is significantly influenced by their characteristics.
Vascular complications of vestibular schwannoma surgery: a comparison of the suboccipital retrosigmoid and translabyrinthine approaches.

OBJECT Vascular complications of the surgery for vestibular schwannomas (VSs) can have devastating consequences; however, there is scant literature on the systematic analysis of the different types of complications. In this context, the authors of this study analyzed these complications, with particular interest in the role of surgical approach in their occurrence. METHODS The charts of 391 patients who had undergone 413 procedures for VS during a 24-year period were reviewed retrospectively. A suboccipital retrosigmoid (RS) approach was used in 338 procedures, and the translabyrinthine (TL) route in 75. Postoperative hemorrhage or infarction was identified and stratified according to the complication type and surgical approach. Postoperative vascular complications were encountered in 11 procedures (2.7%), and their incidence was the same for both the RS and TL approaches. Of these complications, eight were hemorrhagic (two cerebellopontine angle, one intracerebellar, and five epidural hematomas) and three were ischemic in nature. Five patients (45.4%) had a complete recovery, and four patients (36.4%) a partial recovery; two patients (18.2%) died. The overall procedure-related mortality rate was 0.5% (two of 413 procedures): 0.3% (one of 338 procedures) for the RS approach and 1.3% (one of 75 procedures) for the TL approach (p > 0.05). CONCLUSIONS In this study, the overall incidences of vascular complications in VS surgery were similar for the RS and TL approaches. Regardless of the preferred surgical route, this group of complications carries a significant risk of morbidity and therefore warrants special consideration in the management of VSs.
Endovascular thrombectomy for acute ischaemic stroke: a real‐world experience

Endovascular thrombectomy for acute ischaemic stroke due to proximal vessel occlusions in the anterior cerebral circulation within 6 h of stroke onset is now recognised as highly beneficial. Five randomised controlled trials in 2015 showed significant improvement in functional outcome at 90 days compared with intravenous thrombolysis alone. Liverpool Hospital is a tertiary referral centre with an acute stroke service, including 24/7 intravenous thrombolysis and endovascular thrombectomy.
Mediation Effects of Subjective Norms on the Relationship between Career Advancement and Job Characteristics and Knowledge Sharing Behavior among the Tanzanian Healthcare Professionals

This paper intends to examine the mediating effects of subjective norms on the relationship between career advancement and job characteristics and knowledge sharing behavior. Based on the social exchange theory, we establish a research model which contains job and organizational factors. We distributed 650 questionnaires, but only 439 questionnaires were returned and usable. The hypotheses were tested using Partial Least Squares Structural Equation Modeling (PLS-SEM). The study examines knowledge sharing behavior and its determinants. The results reveal that career advancement, job characteristics and subjective norms are positively and significantly related to knowledge sharing behavior. The findings depict that subjective norms have a partial positive and significant mediating effect on knowledge sharing behavior. This paper intends to identify knowledge sharing behavior and its determinants in Tanzanian healthcare institutions and among healthcare professionals. This is because there are only a few such studies in the context of Tanzania; therefore, this study offers a theoretical foundation for future studies and practical implications for administrators and practitioners.
Hearing loss in elderly patients in a family practice.

OBJECTIVE To investigate hearing loss in elderly patients. DESIGN Cohort study. SETTING Family practice. PATIENTS All ambulatory patients 65 years of age or older who attended the practice from June to August 1989. OUTCOME MEASURES The Hearing Handicap Inventory for the Elderly--Screening Version (HHIE-S) and the Welch-Allyn Audioscope. Patients who failed one or both of the screening tests were referred to a speech and hearing clinic for audiologic assessment and treatment recommendations. Those with hearing aids were excluded from the main study but were given the opportunity to have them assessed at the clinic. MAIN RESULTS Of 157 eligible patients 42 were excluded: 16 refused to participate, 13 already had hearing aids, and 13 could not be contacted. Of the remaining 115, 34 failed one or both of the tests (14 failed the HHIE-S, 9 failed the audioscope test, and 11 failed both). Of the 34, 25 completed the audiologic assessment at the clinic. Fifteen were found to have severe hearing impairment; the recommendation was hearing aids for 12, further assessment for 2 and no treatment for 1. Of the remaining 10 patients it was thought that 6 would benefit from hearing aids. Ten of the 11 patients with hearing aids who agreed to undergo testing at the clinic were found to need an adjustment or replacement of their devices. CONCLUSIONS Hearing loss is a significant problem in elderly patients in primary practice. Further study is required to determine which of the two screening tools is most effective. Most elderly patients with hearing aids may require modification or replacement of their devices.
Student Self-Responsibility in the Indonesian Distance Education System

An ongoing concern in the distance education system in Indonesia is students’ lack of commitment to ‘independent study’. The purpose of this paper is to review conceptual frameworks that could empower Indonesian students to accept responsibility for their learning at a level to address the learning challenges of distance education. The review shows that to meet quality and equity expectations in online distance education, independent study modes should promote students’ self-responsibility based primarily on both autonomy and capability. The findings have the potential to add new perspective to education through supporting teaching and learning approaches in an online distance education class to enhance self-responsibility. The paper suggests that students would take more control of independent learning if they accepted primary responsibility to determine their learning needs, resources, activities and outcomes. To do this they need to view themselves as active agents with power to take independent choices that can result in creating their own approaches to resolve their learning limitation.
The Tax Cuts and Jobs Act: An Appraisal

This paper assesses the landmark Tax Cuts and Jobs Act (TCJA), from the perspective of both the U.S. itself and the wider world. The reform has many positive aspects including steps to broaden the base of, and reduce marginal rates under, the personal income tax (PIT), reduce distortions to investment and financing decisions, and mitigate outward profit shifting. But the TCJA has a large fiscal price tag and leaves significant uncertainty as to how the U.S. tax system will develop. The PIT changes could have better targeted relief at low earners, and there is scope to more fully address distortions in business taxation. The novel international provisions create a complex array of both positive and negative international spillovers, and have the potential to significantly reshape the wider international tax system.
Structural insight into epothilones antitumor activity based on the conformational preferences and tubulin binding modes of epothilones A and B obtained from molecular dynamics simulations

Molecular dynamics simulations were employed to analyze the conformational preferences and binding modes of epothilones A and B as a source of structural information regarding the antitumor properties of these species. Our results suggest that the conformation of free and tubulin-bound epothilones is strongly influenced by the presence of a methyl group at C12 and that epothilones A and B exploit the binding cavity in a unique and different way. The binding sites of epothilones A and B share a common region of association (Leu215, Leu217, His227, Leu228, Ala231, Phe270, Gly360, and Leu361), but lead to different ligand–residue interactions. Average interaction energies predict a larger stabilization for the epothilone B–tubulin complex, which is mainly driven by the enhancement of the electrostatic component of ligand–residue interactions compared to the epothilone A–tubulin complex. These structural and energetic results can be useful to account for the activity difference between epothilones A and B, and to design more active and potent analogs that resemble the mechanism of action of epothilones against cancer cells.
A novel role for cyclic nucleotide‐gated cation channels in lung liquid homeostasis in sheep

1 Sheep lungs were artificially perfused in situ with warmed whole oxygenated sheep blood. The airspaces of the lungs were filled with liquid containing an impermeant tracer, to allow measurement of the rate of net transepithelial liquid movement under various conditions. 2 Dichlorobenzamil (1.5 × 10−5m), a blocker of cyclic nucleotide‐gated cation channels, inhibited the resting absorption of lung liquid in sheep aged 6 months (n= 5) (from −36.47 ± 4.62 to −4.36 ± 5.27 ml h−1, means ±s.e.m.; P < 0.005, paired t test). Amiloride (10−4 M), a blocker of epithelial sodium channels, had no additive effect to that of dichlorobenzamil. 3 In the lungs of sheep aged 6 months (n= 4), amiloride (10−4m) partially inhibited the resting absorption of liquid (from −35.21 ± 8.57 to −11.05 ± 4.91 ml h−1; P < 0.05, one‐tailed paired t test), and dichlorobenzamil (1.5 × 10−5 M) exerted an additive effect to that of amiloride resulting in secretion at +6.29 ± 3.05 ml h−1 (P < 0.01, paired t test). 4 In the lungs of sheep aged 6 weeks (n= 3), amiloride (10−4m) also inhibited the resting absorption of liquid (from −26.36 ± 14.05 to −5.17 ± 8.27 ml h−1; P < 0.05, one‐tailed paired t test); however, dichlorobenzamil (1.5 × 10−5m) did not exert an additive effect to that of amiloride. 5 In the lungs of sheep aged 6 months (n= 4), amiloride (10−4m) partially inhibited the resting absorption of liquid (from −35.70 ± 8.58 to −6.79 ± 4.28 ml h−1; P < 0.05, paired t test), and pimozide (1.5 × 10−4m), another blocker of cyclic nucleotide‐gated cation channels, also exerted an additive effect to that of amiloride, resulting in secretion of lung liquid at +15.36 ± 9.14 ml h−1 (P < 0.05, paired t test). 6 We conclude that cyclic nucleotide‐gated cation channels mediate a component of lung liquid absorption in sheep aged 6 months (but not in sheep aged 6 weeks), and that a mechanism for lung liquid secretion (present in fetuses) is retained at 6 months of age.
Practical cost-based approach for the voltage ancillary service

Summary form only given, as follows. The restructuring and deregulation of the electricity sector most noticeably involves the introduction of competition into energy supply. In parallel with this, however, there is an increasing desire amongst transmission system operators, generators and consumers for commercial principles to be applied to transmission services, including the provision of voltage support and reactive power control. The identification of the costs of providing such services is an important first step towards developing a transmission services market. Implementing a payment structure based on the remuneration of incurred costs can be an attractive option to commercial power sector players, who wish such costs to be recoverable at an appropriate rate of return, and system operators, who need to be assured of the availability of the necessary services. This paper addresses both the principles and practical issues involved in developing cost-based payments for reactive power, with reference to the ongoing restructuring of the Brazilian power sector.