Miracle-dz/UniFAR-FTUs huggingface dataset:
Orthogonalization by principal components applied to CPM

The orthonormal basis for the space spanned by a given signal set can be chosen in many different ways. However, when the basis is truncated to fewer dimensions, the quality of the approximated signals differs, depending on the choice of the original basis. We study two energy-related quality measures and show that the optimal lower-dimensional approximation is given by the principal components (PC) method, which is also a simple and efficient alternative to Gram-Schmidt techniques. In addition, we derive and bound the average decrease in squared Euclidean distances over one symbol interval caused by the PC method. This measure is relevant in serially concatenated continuous phase modulation, where a manifold of signal pairs contributes to the bit-error rate for low-to-medium signal-to-noise ratios. By a numerical evaluation, we find that for this measure, the decrease is lower than that of a previous method by J. Huber and W. Liu (see IEEE J. Select. Areas Commun., vol.7, p.1437-49, 1989). Finally, we compare the minimum squared Euclidean distance for error events, which is relevant for uncoded CPM systems. Here, the loss with the PC method is generally larger than with Huber and Liu's method, although examples of the opposite exist.
Molecular architecture of the active mitochondrial protein gate

Dissecting the mitochondrial entry portal Mitochondria, the powerhouses of the cell, are mainly composed of proteins made in the cytosol. These newly synthesized proteins need to be imported across the organelle's membrane through dedicated protein import machinery. Shiota et al. have worked out the architecture and mechanism of the mitochondrial protein import channel. Science, this issue p. 1544 A biochemical analysis reveals how the main protein entry gate of mitochondria imports preproteins. Mitochondria fulfill central functions in cellular energetics, metabolism, and signaling. The outer membrane translocator complex (the TOM complex) imports most mitochondrial proteins, but its architecture is unknown. Using a cross-linking approach, we mapped the active translocator down to single amino acid residues, revealing different transport paths for preproteins through the Tom40 channel. An N-terminal segment of Tom40 passes from the cytosol through the channel to recruit chaperones from the intermembrane space that guide the transfer of hydrophobic preproteins. The translocator contains three Tom40 β-barrel channels sandwiched between a central α-helical Tom22 receptor cluster and external regulatory Tom proteins. The preprotein-translocating trimeric complex exchanges with a dimeric isoform to assemble new TOM complexes. Dynamic coupling of α-helical receptors, β-barrel channels, and chaperones generates a versatile machinery that transports about 1000 different proteins.
Sistema auditivo eferente: efeito no processamento auditivo

O processamento da informacao sonora depende da integridade das vias auditivas aferentes e eferentes. O sistema auditivo eferente pode ser avaliado por meio dos reflexos acusticos e da supressao das emissoes otoacusticas. OBJETIVO: Verificar a atividade do sistema auditivo eferente, por meio da supressao das emissoes otoacusticas (EOA) e da sensibilizacao do reflexo acustico no disturbio de processamento auditivo. CASUISTICA E METODO: Estudo prospectivo: 50 criancas com alteracao de processamento auditivo (grupo estudo) e 38 sem esta alteracao (grupo controle), avaliadas por meio das EOA na ausencia e presenca de ruido contralateral e da pesquisa dos limiares do reflexo acustico na ausencia e presenca de estimulo facilitador contralateral. RESULTADOS: O valor medio da supressao das EOA foi de ate 1,50 dB para o grupo controle e de ate 1,26 dB para o grupo estudo. O valor medio da sensibilizacao dos reflexos foi de ate 14,60 dB para o grupo estudo e de ate 15,21 dB para o grupo controle. Nao houve diferenca estatisticamente significante entre as respostas dos grupos controle e estudo em ambos os procedimentos. CONCLUSAO: O grupo estudo apresentou valores reduzidos na supressao das EOA e valores aumentados na sensibilizacao do reflexo acustico, em relacao ao grupo controle.
A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen

Flu vaccine candidate STEMs the tide Every year we need a new flu vaccine, because influenza virus constantly mutates the major target of antibodies to flu: the “head” region of the viral hemagglutinin (HA) protein. Avoiding the problem of mutation requires a vaccine that elicits antibodies against the more conserved “stem” region of HA. During infection, antibodies are occasionally produced that recognize the stem and that neutralize a broad range of influenza virus strains. Impagliazzo et al. engineered an HA stem–only vaccine candidate that elicited broadly neutralizing antibodies in mice and nonhuman primates and that protected mice against multiple influenza strains. Science, this issue p. 1301 An engineered stem-only hemagglutinin vaccine candidate provides broad protection in an animal model of influenza infection. The identification of human broadly neutralizing antibodies (bnAbs) targeting the hemagglutinin (HA) stem revitalized hopes of developing a universal influenza vaccine. Using a rational design and library approach, we engineered stable HA stem antigens (“mini-HAs”) based on an H1 subtype sequence. Our most advanced candidate exhibits structural and bnAb binding properties comparable to those of full-length HA, completely protects mice in lethal heterologous and heterosubtypic challenge models, and reduces fever after sublethal challenge in cynomolgus monkeys. Antibodies elicited by this mini-HA in mice and nonhuman primates bound a wide range of HAs, competed with human bnAbs for HA stem binding, neutralized H5N1 viruses, and mediated antibody-dependent effector activity. These results represent a proof of concept for the design of HA stem mimics that elicit bnAbs against influenza A group 1 viruses.
Body-size reduction in vertebrates following the end-Devonian mass extinction

The small will inherit the Earth… Understanding how communities and ecosystems recovered from the previous five global extinction events sheds light on how extinctions shape broad patterns of biodiversity. Sallan et al. looked across vertebrate species during and after the Devonian extinction (see the Perspective by Wagner). Small-bodied species, with rapid reproductive rates, dominated post-extinction communities, despite the presence of many successful large-bodied species before the extinction. This pattern mimics, to some degree, current patterns of extinction, suggesting that we might expect similar loss of large-bodied species if we continue along our current path. Science, this issue p. 812; see also p. 736 Similar to ongoing extinctions, the end-Devonian extinction resulted in the loss of most large-bodied vertebrates. [Also see Perspective by Wagner] Following the end-Devonian mass extinction (359 million years ago), vertebrates experienced persistent reductions in body size for at least 36 million years. Global shrinkage was not related to oxygen or temperature, which suggests that ecological drivers played a key role in determining the length and direction of size trends. Small, fast-breeding ray-finned fishes, sharks, and tetrapods, most under 1 meter in length from snout to tail, radiated to dominate postextinction ecosystems and vertebrae biodiversity. The few large-bodied, slow-breeding survivors failed to diversify, facing extinction despite earlier evolutionary success. Thus, the recovery interval resembled modern ecological successions in terms of active selection on size and related life histories. Disruption of global vertebrate, and particularly fish, biotas may commonly lead to widespread, long-term reduction in body size, structuring future biodiversity.
Enhanced multiple-bit differential detection of DOQPSK

In this paper, we consider multiple-bit differential detection (MBDD) of differential offset quadrature phase-shift keying (DOQPSK) with conventional bit-wise differential encoding (DE). We propose two novel MBDD schemes that outperform Simon's MBDD and approach the performance of coherent detection (CD) as the observation window size N increases. The first scheme uses the full available detection window spanning N-1 bit intervals, and is referred to as F-MBDD. A careful bit-error rate (BER) analysis shows that a significant performance improvement can be realized by reducing the detection window size to N-3 bit intervals. The resulting improved MBDD (I-MBDD) of DOQPSK with bit-wise DE achieves a similar performance as Phoel's MBDD of DOQPSK with more complex symbol-wise DE. For both F-MBDD and I-MBDD, tight upper bounds and accurate BER approximations are derived. In addition, since the complexity per bit decision of brute-force decoding of MBDD of DOQPSK grows exponentially with N, we develop optimum and suboptimum fast decoding algorithms with complexities per bit decision of orders log(N+1) and N, respectively.
The brain’s functional network architecture reveals human motives

Brain activity shows underlying motives In humans, two completely different motives may nevertheless lead to exactly the same behavior. Because we can't directly observe motives, modern economists often completely disregard them. However, Hein et al., using fMRI, show that different human motives can yield observable responses in the brain (see the Perspective by Gluth and Fontanesi). In empathy-based and reciprocity-based altruistic behavior, the direction and the strength of functional connectivity between specific brain regions were different for each motive. Moreover, the connectivity patterns were independent of the behavioral implications of the motives. Science, this issue p. 1074; see also p. 1028 Connectivity patterns in human brain circuits can predict distinct motivations for similar observed behaviors. [Also see Perspective by Gluth and Fontanesi] Goal-directed human behaviors are driven by motives. Motives are, however, purely mental constructs that are not directly observable. Here, we show that the brain’s functional network architecture captures information that predicts different motives behind the same altruistic act with high accuracy. In contrast, mere activity in these regions contains no information about motives. Empathy-based altruism is primarily characterized by a positive connectivity from the anterior cingulate cortex (ACC) to the anterior insula (AI), whereas reciprocity-based altruism additionally invokes strong positive connectivity from the AI to the ACC and even stronger positive connectivity from the AI to the ventral striatum. Moreover, predominantly selfish individuals show distinct functional architectures compared to altruists, and they only increase altruistic behavior in response to empathy inductions, but not reciprocity inductions.
Intensive Care in Patients With HIV Infection in the Era of Highly Active Antiretroviral Therapy

Study objectives The use of highly active antiretroviral therapy (HAART) has dramatically improved morbidity and mortality in patients with HIV infection. The types of critical illness and their outcomes in HIV-infected patients in recent years is unknown. Design We reviewed the medical records of all patients admitted to the Medical ICU of Beth Israel Medical Center, NY, from January to June 2001 and compared their characteristics with patients admitted to the same unit from November 1991 to October 1992. Results Of 441 admissions in the first half of 2001, 63 admissions (14%) were in 53 HIV-seropositive patients. There were 65 admissions to the Medical ICU during the 1-year period spanning 1991 to 1992. Compared with the earlier period, the 2001 patients were more likely to be black (52% vs 26%, respectively; p Pneumocystis jiroveci pneumonia (formerly referred to as Pneumocystis carinii ) [3% vs 34%, respectively; p Conclusions In the era of HAART, more patients with HIV infection were admitted to the ICU over a 12-month period than were 10 years previously. Patients were more likely to be injection drug users and were more likely to be admitted to the ICU because of non-HIV-associated conditions.
THE INITIAL LESION IN EXPERIMENTAL ALLERGIC NEURITIS

Experimental allergic neuritis (EAN) was produced in rats by the intradermal injection of an emulsion of peripheral nerve in Freund's adjuvant. Early lesions in perfused sciatic nerves were studied by phase, light, and electron microscopy at intervals up to 15 days following immunization. Circulating lymphocytes attached focally to the inner surface of blood vessels, primarily venules, to initiate parenchymal lesion formation. Attached cells had the hand mirror configuration typical of the motile lymphocyte. They subsequently flattened against the endothelial surface and then traversed the vascular wall by sinking into and passing through the cytoplasm of endothelial cells. The transgressor and transgressed cell membranes were intact and both cells retained their integrity. Lymphocytes began to transform and divide intravascularly; these events accelerated extravascularly. Although the migrating cells became larger and more pleomorphic in the perivascular regions, their essential character was in keeping with an origin from circulating lymphocytes. In many lesions, there was fluid with protein, possibly produced by the transformed extravascular cells. The described cellular events precede tissue damage and are likely instrumental in the myelin destruction which follows
Gut microbiota and aging

The potential for the gut microbiota to affect health has a particular relevance for older individuals. This is because the microbiota may modulate aging-related changes in innate immunity, sarcopaenia, and cognitive function, all of which are elements of frailty. Both cell culture–dependent and –independent studies show that the gut microbiota of older people differs from that of younger adults. There is no chronological threshold or age at which the composition of the microbiota suddenly alters; rather, changes occur gradually with time. Our detailed analyses have separated the microbiota into groups associated with age, long-term residential care, habitual diet, and degree of retention of a core microbiome. We are beginning to understand how these groups change with aging and how they relate to clinical phenotypes. These data provide a framework for analyzing microbiota-health associations, distinguishing correlation from causation, identifying microbiota interaction with physiological aging processes, and developing microbiota-based health surveillance for older adults.
School Nurses’ Professional Practice in the HPV Vaccine Decision-Making Process

Because U.S. human papillomavirus (HPV) vaccination rates remain low, we evaluated school nurses’ knowledge, attitudes, perceptions of their role as opinion leaders, self-efficacy, intention, and professional practice regarding the HPV vaccine and determined if these variables influenced their professional practice concerning the HPV vaccine. We utilized a cross-sectional design by recruiting Ohio Association of School Nurses (OASN) members. Participants (n = 145) completed a paper survey during the OASN annual conference. Structural equation modeling was used to examine the proposed model. Our model yielded a well-fitting solution, χ2 = 1.118 (degrees of freedom = 2, p = .57). Knowledge had positive effects on intention and self-efficacy. Attitude had a positive effect on perception of role as opinion leaders. Intention to provide HPV vaccine education had a positive effect on professional practice. To develop school nurses’ practice, interventions should center on increasing knowledge, attitudes, and intention toward providing HPV vaccine education.
Cell nonautonomous activation of flavin-containing monooxygenase promotes longevity and health span

Aging: All in the head—and the gut The effects of hypoxia and caloric restriction, both of which extend life span in Caenorhabditis elegans, converge on the activation of an enzyme in cells of the intestine. Leiser et al. show that the life-extending effects of hypoxia begin in neurons with transcriptional activation by hypoxia-inducible factor–1 and increased serotonergic signaling. These effects lead to increased production of flavin-containing monooxygenase-2 (FMO-2) in the intestine, which increased longevity. Finding the relevant targets of FMO-2, which also accumulates in mammals under conditions that promote longevity, may elucidate further mechanisms that promote healthy aging. Science, this issue p. 1375 Two life-span–extending pathways in the worm converge to increase production of an enzyme in the intestine. Stabilization of the hypoxia-inducible factor 1 (HIF-1) increases life span and health span in nematodes through an unknown mechanism. We report that neuronal stabilization of HIF-1 mediates these effects in Caenorhabditis elegans through a cell nonautonomous signal to the intestine, which results in activation of the xenobiotic detoxification enzyme flavin-containing monooxygenase-2 (FMO-2). This prolongevity signal requires the serotonin biosynthetic enzyme TPH-1 in neurons and the serotonin receptor SER-7 in the intestine. Intestinal FMO-2 is also activated by dietary restriction (DR) and is necessary for DR-mediated life-span extension, which suggests that this enzyme represents a point of convergence for two distinct longevity pathways. FMOs are conserved in eukaryotes and induced by multiple life span–extending interventions in mice, which suggests that these enzymes may play a critical role in promoting health and longevity across phyla.
De novo mutations in congenital heart disease with neurodevelopmental and other congenital anomalies

Putting both heart and brain at risk For reasons that are unclear, newborns with congenital heart disease (CHD) have a high risk of neurodevelopmental disabilities. Homsy et al. performed exome sequence analysis of 1200 CHD patients and their parents to identify spontaneously arising (de novo) mutations. Patients with both CHD and neurodevelopmental disorders had a much higher burden of damaging de novo mutations, particularly in genes with likely roles in both heart and brain development. Thus, clinical genotyping of patients with CHD may help to identify those at greatest risk of neurodevelopmental disabilities, allowing surveillance and early intervention. Science, this issue p. 1262 Genotyping of children with congenital heart disease may identify those at high risk of neurodevelopmental disorders. Congenital heart disease (CHD) patients have an increased prevalence of extracardiac congenital anomalies (CAs) and risk of neurodevelopmental disabilities (NDDs). Exome sequencing of 1213 CHD parent-offspring trios identified an excess of protein-damaging de novo mutations, especially in genes highly expressed in the developing heart and brain. These mutations accounted for 20% of patients with CHD, NDD, and CA but only 2% of patients with isolated CHD. Mutations altered genes involved in morphogenesis, chromatin modification, and transcriptional regulation, including multiple mutations in RBFOX2, a regulator of mRNA splicing. Genes mutated in other cohorts examined for NDD were enriched in CHD cases, particularly those with coexisting NDD. These findings reveal shared genetic contributions to CHD, NDD, and CA and provide opportunities for improved prognostic assessment and early therapeutic intervention in CHD patients.
Simple Average BER Formulas for M-ary Orthogonal Signals with Noncoherent Diversity Combining in Nakagami-m Fading Channels

This paper presents simple and exact expressions for the average bit error rate (BER) of M-ary orthogonal signals with noncoherent diversity combining in independent as well as arbitrarily correlated nonidentically distributed Nakagami-m fading channels. The expressions are given in terms of elementary functions, and they do not involve numerical integrals or complicated functional operations. In addition, they are valid for the generalized case when the channels have arbitrary average signal- to-noise ratios (SNRs) as well as nonidentical fading parameters. Simulation results are provided to validate the analytical results.
The Role of School Health Services in Addressing the Needs of Students With Chronic Health Conditions

Children and adolescents in the United States spend many hours in school. Students with chronic health conditions (CHCs) may face lower academic achievement, increased disability, fewer job opportunities, and limited community interactions as they enter adulthood. School health services provide safe and effective management of CHCs, often for students with limited access to health care. A systematic review to assess the role of school health services in addressing CHCs among students in Grades K–12 was completed using primary, peer-reviewed literature published from 2000 to 2015, on selected conditions: asthma, food allergies, diabetes, seizure disorders, and poor oral health. Thirty-nine articles met the inclusion criteria and results were synthesized; however, 38 were on asthma. Direct access to school nursing and other health services, as well as disease-specific education, improved health and academic outcomes among students with CHCs. Future research needs to include standardized definitions and data collection methods for students with CHCs.
Josephson effect in fermionic superfluids across the BEC-BCS crossover

Simulating electronic transport with atoms Two superconductors connected by a bridge made out of nonsuperconducting material form a so-called Josephson junction (see the Perspective by Belzig). Valtolina et al. replaced the superconductors with two reservoirs of a superfluid Fermi gas and connected them by a weak link to allow atoms to move from one side to the other. Then they made one reservoir more populated than the other and studied the ensuing dynamics as a function of interaction strength between the atoms. In a related experiment, Husmann et al. kept the interaction strength at its maximum, but varied the temperature and the properties of the link. As temperature increased, the superfluid disappeared and thermal transport took over. Science, this issue p. 1498, p. 1505; see also p. 1470 The effects of interaction strength are studied in a junction composed of two 6Li superfluids. [Also see Perspective by Belzig] The Josephson effect is a macroscopic quantum phenomenon that reveals the broken symmetry associated with any superfluid state. Here we report on the observation of the Josephson effect between two fermionic superfluids coupled through a thin tunneling barrier. We show that the relative population and phase are canonically conjugate dynamical variables throughout the crossover from the molecular Bose-Einstein condensate (BEC) to the Bardeen-Cooper-Schrieffer (BCS) superfluid regime. For larger initial excitations from equilibrium, the dynamics of the superfluids become dissipative, which we ascribe to the propagation of vortices through the superfluid bulk. Our results highlight the robust nature of resonant superfluids.