Miracle-dz/UniFAR-FTUs huggingface dataset:
Sex differences among non-brain-damaged adults on the Wechsler Adult Intelligence Scales: a review of the literature.

We reviewed studies of the performance of non-brain-damaged men and women on the Wechsler Adult Intelligence Scales (i.e., the Wechsler-Bellevue, Wechsler Adult Intelligence Scale, and Wechsler Adult Intelligence Scale-Revised) to determine if there were sex differences on specific test items, on specific subtests, or on Verbal IQ, Performance IQ, or the Verbal-Performance Discrepancy score. There were sex differences on some items of each of the three measures, but the number of such differences was small. A number of studies suggested differences on subtests of these scales. A meta-analysis indicated that females tended to outperform males by about a third of a standard deviation on the Digit Symbol subtest, while males tended to outperform females to the same extent or greater on the Arithmetic and Information subtests. Finally, in the few studies on IQ or discrepancy-score differences, there was no evidence of any consistent differences between the sexes in the Verbal-Performance Discrepancy, although there was some tendency for males to obtain higher Verbal IQs. This review, therefore, does not suggest that there are any major differences between non-brain-damaged males and females on the Wechsler adult intelligence scales.
Media Effects on Group Collaboration: An Empirical Examination in an Ethical Decision-Making Context

Even though it is widely acknowledged that collaboration underlies much of the decision-making efforts in contemporary organizations, and that organizational groups are increasingly making decisions that have ethical implications, few studies have examined group ethical decision-making processes and outcomes. In addition, while there is increasing evidence that groups often collaborate/communicate using different mediating technologies, few studies have examined the effect of the characteristics of the media in group ethical decision-making contexts. Finally, there is a clear paucity of studies that have investigated group decision making pertaining to information technology (IT)-related ethical dilemmas, an area of rising importance for information systems (IS) and decision science researchers. This article seeks to address the gaps described above through an experimental study where groups collaborating either in a face-to-face context or in a computer-mediated context (using NetMeeting or Wiki) were required to make a decision with respect to a scenario with an IT-related ethical dilemma. Results indicate that media characteristics (e.g., anonymity, immediacy of feedback, parallelism) do not have an effect on whether groups make ethical (or unethical) decisions. However, several media characteristics were found to play a significant role on downstream variables, such as the quality of a follow-up task (i.e., creation of a decision justification document), and overall process satisfaction of the group members.
Antibodies to the core protein of lymphadenopathy-associated virus (LAV) in patients with AIDS.

Lymphadenopathy-associated virus ( LAV ), a human T- lymphotrophic retrovirus isolated from a homosexual man with lymphadenopathy, has been causally associated with acquired immunodeficiency syndrome (AIDS). A sensitive and specific radioimmunoprecipitation test was developed for the detection of antibodies to the major core protein of LAV , p25 (molecular weight 25,000). Antibody to LAV p25 was found in the serum of 51 of 125 AIDS patients, 81 of 113 patients with lymphadenopathy syndrome, 0 of 70 workers at the Centers for Disease Control (some of whom had handled specimens from AIDS patients), and 0 of 189 random blood donors. Of a group of 100 homosexual men from San Francisco whose serum was obtained in 1978, only one had antibody to LAV p25; in contrast, of a group of 50 homosexual men in the same community whose serum was obtained in 1984, 12 had antibodies to LAV p25.
Stochastic epidemic models for tick-borne diseases

This thesis consists of two papers 1. Wangombe A. , Andersson M. , Britton T. (2009): A stochastic epidemic model for tick borne diseases: initial stages of an outbreak and endemic levels, (submitted). 2. Wangombe A. , Andersson M. , Britton T. (2009): A stage-structured stochastic epidemic model for tick borne diseases, (Manuscript). Both papers deal with the formulation of stochastic models for the spread of tick-borne diseases amongst cattle. Multi-type branching process approximation of the early stages of the epidemic process is used to derive a threshold quantity which determines whether an epidemic may take off in the tick-host system as well as outbreak probabilities when above threshold. Expressions of the endemic level in case of a major outbreak are also derived. A ”homogeneous version” of the stage-structured model is defined and compared with the onestage model. It is shown that the two models are different.
Adenovirus Type 5 Early Region 1B 156R Protein Promotes Cell Transformation Independently of Repression of p53-Stimulated Transcription

ABSTRACT Early region 1B (E1B) of adenovirus type 5 (Ad5) encodes at least five different polypeptides generated by alternative splicing of a common mRNA precursor. Two of these gene products, E1B-19K and E1B-55K, are individually capable of cooperating with the Ad5 E1A proteins to completely transform rodent cells in culture. Substantial evidence suggests that these two E1B proteins contribute to cell transformation by antagonizing growth arrest and apoptosis. Here, we performed genetic and biochemical analyses to assess the attributes of the remaining E1B proteins (E1B-156R, E1B-93R, and E1B-84R). Our results show that E1B-156R, which comprises the 79 amino-terminal and 77 carboxy-terminal amino acids of E1B-55K, also enhances focal transformation of primary rat cells in cooperation with E1A. Since E1B-156R seemed unable to relocalize p53 and inhibit its transactivating function, it must be assumed that it contributes to transformation independently of repression of p53-stimulated transcription. Furthermore, we discovered that E1B-156R contains a functional transcriptional repression domain and binds Ad5 E4orf6 and the cellular apoptosis regulator Daxx. While the ability to bind E4orf6 could indicate further biological functions of E1B-156R in viral infection, the interaction with Daxx might also be linked to its transforming potential. Taken together, these analyses introduce E1B-156R as a novel transformation-promoting E1B protein that acts without repressing p53 transactivation. Moreover, identification of the interaction partners E4orf6 and Daxx provides a first glance of E1B-156R's potential functions.
Oligodendrocyte and astrocyte development in rodents: An in situ and immunohistological analysis during embryonic development

Lineally related multipotent neuroepithelial cells (NEP), neuronal restricted precursors (NRP), and glial restricted precursors (GRP) have been identified in the spinal cord. To determine the sequence of differentiation and identify lineage and stage‐specific markers, we have examined the spatiotemporal expression of established glial markers during rodent embryonic development and within fetal cell culture. In this report, we show that proliferating stem cells in the developing neural tube do not express any glial markers at E10.5. By E11, however, glial precursors have begun to differentiate and at least two regions of the ventral neural tube containing glial precursor cells can be distinguished, an Nkx2.2/Neurogenin 3 (Ngn3) domain and a platelet‐derived growth factor receptor alpha (PDGFRα)/Olig2/Sox10 domain. Radial glia, as identified by RC1 immunoreactivity, develop in concert with other glial precursors and can be distinguished by their morphology, spatial distribution, and antigen expression. Astrocytes as assessed by glial fibrillary acidic protein (GFAP) immunoreactivity are first detected at E16. A novel dorsal domain of CD44 immunoreactivity that can be distinguished from the more ventral glial precursor domains can be detected as early as E13.5. GLIA 40:25–43, 2002. Published 2002 Wiley‐Liss, Inc.
A partial syntactic analysis-based pre-processor for automatic indexing and retrieval of Chinese texts

Automatic indexing is the automatic creation of a text surrogate, normally keywords or phrases, to represent the original text. In the current English text retrieval systems, this process of content representation is accomplished by extracting words using spaces and punctuations as word delimiters. The same technique cannot easily be applied to Chinese texts which contain no obvious word boundaries; they appear to be a linear sequence of non-spaced or equally spaced ideographic characters and thenumber of characters in words varies. The solution to the problem lies in morphological and syntactic analyses of Chinese morphemes, words and phrases. The idea is inspired by the experiments on English computational morphology and its application to English text retrieval, mainly automatic compound and phrase indexing. These areas are particularly germane to Chinese because typographically there are no morph and phrase boundaries in either Chinese or English texts. The experiment is based on the hypothesis that words and phrases exceeding two Chinese characters can be characterised by a grammar that describes the concatenation behaviour of morphological and syntactic categories. This is examined using the following three procedures: (1) text segmentation - texts are divided into one and two character segments by searching a dictionary containing over 17000 morphemes and words, which are tagged with 'morphological and syntactic categories. (2) category disambiguation - for the resulting morphemes and words tagged with more than one category, the correct one is selected based on context (3) parsing - the segments are analysed using the grammar, which combines them into compound and complex words and phrases for indexing and retrieval. The utilities employed in the experiment include CCOOS, an extended version of MSOOS providing for Chinese I/O system,Chinese Wordstar for text input and Chinese dBASEIII for dictionary construction. Source codes are written in Turbo BASIC including its database toolbox. Thiny texts are drawn randomly from newspapers to form thcsample for the experiment. The results prove that the partial syntactic analysis-based approach can extract keywords with a good degree of accuracy.
Effect of smoking on glycosylated hemoglobin ( HbA 1 c ) among patients with diabetes mellitus type II

Smoking in patients with diabetes was widespread. The level of HbA1c correlated well with the glycemic control over a period of 2 to 3 months, leading to the gradual incorporation of the test into clinical practice. Aim of the study is to study associations between smoking and glycemic control as reflected by HbA1c. A crosssectional study aimed to study the associations between smoking and glycemic control as reflected by HbA1c with an analytic element. This study was performed by participating 160 diabetic patients whom attended the diabetes center in Al-Amarah city, during the period from September, 2014 to April 2015. HbA1c <7% (<53 mmol/mol) in adults consider a target value. This study was show that higher percent of smoking were in middle age group (40-54 years) diabetic patients. There was a high prevalence of smoking among male patients with DM. The conclusion was a significant association (P value < 0.05) between smoking and poor glycemic control in type II diabetic patients in compare with those nonsmokers diabetics.
Induction and Inhibition of Apoptosis by Pseudorabies Virus in the Trigeminal Ganglion during Acute Infection of Swine

ABSTRACT We examined the ability of pseudorabies virus (PRV) to induce and suppress apoptosis in the trigeminal ganglion during acute infection of its natural host. Eight pigs were intranasally inoculated with a virulent field strain of PRV, and at various early times after inoculation, the trigeminal ganglia were assessed histologically. PRV-infected cells were detected by use of immunohistochemistry and in situ hybridization, and apoptosis was identified by in situ terminal deoxynucleotidyltransferase-mediated dUTP nick end labeling. Light and electron microscopy was also used for morphological studies. Apoptosis was readily detected among infiltrating immune cells that were located surrounding PRV-infected neurons. The majority of PRV-infected neurons did not show morphological or histochemical evidence of apoptosis, even including those neurons that were surrounded by numerous inflammatory cells and exhibited profound pathological changes. However, neuronal virus-induced apoptosis also occurred but at a sporadic low level. These findings suggest that PRV is able to block apoptosis of infected trigeminal ganglionic neurons during acute infection of swine. Furthermore, our results also suggest that apoptosis of infiltrating inflammatory cells may represent an important viral mechanism of immune evasion.
Conditioning regimen-dependent disposition of cyclophosphamide and hydroxycyclophosphamide in human marrow transplantation patients.

PURPOSE The pharmacokinetics of cyclophosphamide (CY) and 4-hydroxycyclophosphamide (HCY) were studied in 14 patients being prepared for bone marrow transplantation with either busulfan (BU)/CY (n = 7) or CY/total-body irradiation (TBI) (n = 7) to determine whether exposure to CY and its proximate toxic metabolite HCY is modulated by other agents used in the preparative regimen. PATIENTS AND METHODS HCY was assayed by a new method that stabilized the metabolite at bedside. In BU/CY patients (who also received phenytoin), CY clearance was 112% greater (P = .0014), half-life 54% less (P = .0027), peak HCY concentration in plasma/CY dose 113% greater (P = .0006), and the ratio of area under the plasma concentration-time curves (AUCs) of HCY to CY 166% greater (P = .0116) than in CY/TBI patients. The ratio of the AUC of HCY/CY dose was 48% greater in BU/CY patients than in CY/TBI patients when one CY/TBI patient with an apparent impaired ability to eliminate HCY was excluded from analysis. In CY/TBI patients, there was an inverse correlation between the AUC of HCY and that of CY (R2 = .740, P = .028). Also, the ratio of the AUC of HCY/CY dose was correlated with the average concentration of BU at steady-state (Css, Bu) (R2 = .646, P = 0.29). Variability in CY and HCY pharmacokinetics among the 14 patients overall was pronounced, with the highest variability (15-fold) observed in the ratio of the AUC of HCY to that of CY. CONCLUSION Prior administration of BU and/or phenytoin significantly alters exposure to CY and HCY. Interpatient variability in HCY exposure at a given CY dose is substantial.
Does Dynamic Efficiency of Public Policy Promote Export Prformance? Evidence from Bioenergy Technology Sector

This study examines how the dynamic efficiency of public policy influences the export performance of bioenergy technologies in the short and long run using panel data over the 1995–2012 period for 16 countries that are members of the OECD. Various dynamic panel framework tests to check data characteristics are performed. The study found evidence of co-movement among the series, and set up the panel vector error correction mechanism to evaluate the short- and long-run Granger-causality between the following variables: dynamic efficiency of public policy, export, and environmental policy stringency. This study highlighted positive effects of the dynamic efficiency of public policy and environmental policy efforts on exports in both the short and long run. This study proposes policy considerations based on its results.
A method to estimate free-living active and sedentary behavior from an accelerometer.

INTRODUCTION Methods to estimate physical activity (PA) and sedentary behavior (SB) from wearable monitors need to be validated in free-living settings. PURPOSE The purpose of this study was to develop and validate two novel machine-learning methods (Sojourn-1 Axis [soj-1x] and Sojourn-3 Axis [soj-3x]) in a free-living setting. METHODS Participants were directly observed in their natural environment for 10 consecutive hours on three separate occasions. Physical activity and SB estimated from soj-1x, soj-3x, and a neural network previously calibrated in the laboratory (lab-nnet) were compared with direct observation. RESULTS Compared with lab-nnet, soj-1x and soj-3x improved estimates of MET-hours (lab-nnet: % bias [95% confidence interval] = 33.1 [25.9 to 40.4], root-mean-square error [RMSE] = 5.4 [4.6-6.2]; soj-1x: % bias = 1.9 [-2.0 to 5.9], RMSE = 1.0 [0.6 to 1.3]; soj-3x: % bias = 3.4 [0.0 to 6.7], RMSE = 1.0 [0.6 to 1.5]) and minutes in different intensity categories {lab-nnet: % bias = -8.2 (sedentary), -8.2 (light), and 72.8 (moderate-to-vigorous PA [MVPA]); soj-1x: % bias = 8.8 (sedentary), -18.5 (light), and -1.0 (MVPA); soj-3x: % bias = 0.5 (sedentary), -0.8 (light), and -1.0 (MVPA)}. Soj-1x and soj-3x also produced accurate estimates of guideline minutes and breaks from sedentary time. CONCLUSIONS Compared with the lab-nnet algorithm, soj-1x and soj-3x improved the accuracy and precision in estimating free-living MET-hours, sedentary time, and time spent in light-intensity activity and MVPA. In addition, soj-3x is superior to soj-1x in differentiating SB from light-intensity activity.
Special considerations for the treatment of chronic kidney disease in the elderly

ABSTRACT Chronic kidney disease (CKD) is common in older adults, and its burden is expected to increase in older populations. Even if the knowledge on the approach to older patient with CKD is still evolving, current guidelines for pharmacological management of CKD does not include specific recommendations for older patients. Additionally, decision-making on renal replacement therapy (RRT) for older patients is far from being evidence-based, and despite the improvement in dialysis outcomes, RRT may cause more harm than benefit compared with conservative care when prognostic stratification is not carefully assessed. The use of comprehensive geriatric assessment tools could help clinicians in applying a more informed decision-making. Finally, physical exercise and rehabilitation interventions also represents a promising therapeutic strategy.
Diagnostics of Coronal Magnetic Fields through the Hanle Effect in UV and IR Lines

The plasma thermodynamics in the solar upper atmosphere, particularly in the corona, are dominated by the magnetic field, which controls the flow and dissipation of energy. The relative lack of knowledge of the coronal vector magnetic field is a major handicap for progress in coronal physics. This makes the development of measurement methods of coronal magnetic fields a high priority in solar physics. The Hanle effect in the UV and IR spectral lines is a largely unexplored diagnostic. We use magnetohydrodynamic (MHD) simulations to study the magnitude of the signal to be expected for typical coronal magnetic fields for selected spectral lines in the UV and IR wavelength ranges, namely the H I Ly-$\alpha$ and the He I 10830 A lines. We show that the selected lines are useful for reliable diagnosis of coronal magnetic fields. The results show that the combination of polarization measurements of spectral lines with different sensitivities to the Hanle effect may be most appropriate for deducing coronal magnetic properties from future observations.
Spontaneous reversibility of damage to outer hair cells after sodium salicylate induced ototoxicity.

BACKGROUND High sodium salicylate doses can cause reversible hearing loss and tinnitus, possibly due to reduced outer hair cell electromotility. Sodium salicylate is known to alter outer hair cell structure and function. This study determined the reversibility and cochlear recovery time after administration of an ototoxic sodium salicylate dose to guinea pigs with normal cochlear function. STUDY DESIGN Prospective experimental investigation. METHODS All animals received a single 500 mg sodium salicylate dose, but with different durations of action. Function was evaluated before drug administration and immediately before sacrifice. Cochleae were processed and viewed using scanning electron microscopy. RESULTS Changes in outer hair cell function were observed to be present 2 hours after drug administration, with recovery of normal anatomy beginning after 24 hours. Subsequently, derangement and distortion of cilia reduced, with effects predominantly in row three. At 168 hours, cilia were near-normal but with mild distortions which interfered with normal cochlear physiology. CONCLUSIONS Ciliary changes persisted for up to 168 hours after ototoxic sodium salicylate administration.
The Outcome of Family Interventions for the Mothers of Schizophrenia Patients in Iran

Family intervention in schizophrenia is known to reduce high expressed emotion (EE) burden in relatives, reduce patients’ relapse and improve patient functioning; but these issues have not been studied in Iran. Aims: To examine the effects of behavioural family management (based on Falloon’s model) for Iranian mothers of patients with schizophrenia, compared with psychoeducation and standard care. Method: Randomized controlled trial in Iran with 55 mothers of outpatients with schizophrenia, of whom 18 received behavioural family management, 19 psychoeducation and 18 standard care. All groups included mothers in all sessions and excluded the patients. Intervention was provided for three months and outcomes were compared at the end of intervention (T1) and over a follow-up period: after three months (T2) and after six months (T3). Results: Psychoeducation consistently produced greater reduced burden in mothers and reduced positive symptoms in patients over the intervention and follow-up periods, compared with the other two treatments. On the other hand, behavioural family management significantly reduced EE in mothers compared to the other groups. However, the results indicated that family interventions have benefits for mothers and patients. Conclusions: Family interventions for Iranian mothers of schizophrenia patients can substantially benefit from family functioning.