Miracle-dz/UniFAR-FTUs huggingface dataset:
High intensity focused ultrasound (HIFU) applied to hepato-bilio-pancreatic and the digestive system-current state of the art and future perspectives.

BACKGROUND High intensity focused ultrasound (HIFU) is emerging as a valid minimally-invasive image-guided treatment of malignancies. We aimed to review to current state of the art of HIFU therapy applied to the digestive system and discuss some promising avenues of the technology. METHODS Pertinent studies were identified through PubMed and Embase search engines using the following keywords, combined in different ways: HIFU, esophagus, stomach, liver, pancreas, gallbladder, colon, rectum, and cancer. Experimental proof of the concept of endoluminal HIFU mucosa/submucosa ablation using a custom-made transducer has been obtained in vivo in the porcine model. RESULTS Forty-four studies reported on the clinical use of HIFU to treat liver lesions, while 19 series were found on HIFU treatment of pancreatic cancers and four studies included patients suffering from both liver and pancreatic cancers, reporting on a total of 1,682 and 823 cases for liver and pancreas, respectively. Only very limited comparative prospective studies have been reported. CONCLUSIONS Digestive system clinical applications of HIFU are limited to pancreatic and liver cancer. It is safe and well tolerated. The exact place in the hepatocellular carcinoma (HCC) management algorithm remains to be defined. HIFU seems to add clear survival advantages over trans arterial chemo embolization (TACE) alone and similar results when compared to radio frequency (RF). For pancreatic cancer, HIFU achieves consistent cancer-related pain relief. Further research is warranted to improve targeting accuracy and efficacy monitoring. Furthermore, additional work is required to transfer this technology on appealing treatments such as endoscopic HIFU-based therapies.
Repeatability of scores on a novel test of endurance running performance

Abstract The aim of the present study was to determine the repeatability of a running endurance test using an automated treadmill system that requires no manual input to control running speed. On three separate occasions, 7 days apart, 10 experienced male endurance-trained runners (mean age 32 years, s = 10; [Vdot]O2peak 61 ml · kg−1 · min−1, s = 7) completed a treadmill time trial, in which they were instructed to run as far as possible in 60 min. The treadmill was instrumented with an ultrasonic feedback-controlled radar modulator that spontaneously regulated treadmill belt speed corresponding to the changing running speed of each runner. Estimated running intensity was 70%[Vdot]O2peak (s = 11) and the distance covered 13.5 km (s = 2), with no difference in mean performances between trials. The coefficient of variation, estimated using analysis of variance, with participant and trial as main effects, was 1.4%. In summary, the use of an automated treadmill system improved the repeatability of a 60-min treadmill time trial compared with time trials in which speed is controlled manually. The present protocol is a reliable method of assessing endurance performance in endurance-trained runners.
Large C-band phase sensitive gain in a periodically-poled lithium-niobate waveguide

We use high pump power to demonstrate large C-band phase sensitive gain in a periodically-poled lithium-niobate waveguide chip for the first time. We measure a maximum gain/attenuation dynamic range of 9.4dB with over 3.6dB phase sensitive gain compared to phase insensitive operation. We also observe phase sensitive gain over a 17nm bandwidth limited by the booster EDFA gain spectrum.
The effects of antioxidants on a porcine model of liver hemorrhage

PURPOSE The aim of this study is to assess the efficacy of the combination of N-acetylcysteine (NAC) and deferoxamine (DFO) in the resuscitation from hemorrhagic shock in a porcine model of bleeding during hepatectomy. METHODS Twenty-one pigs were divided randomly to three groups: Sham (S) group, n = 5; fluid (F) resuscitation group, n = 8; and fluid plus NAC plus DFO (NAC&DFO) resuscitation group, n = 8. The animals of groups F and NAC&DFO were subjected to left hepatectomy and controlled hemorrhage from the traumatic liver surface. Shock was established within 10 minutes and maintained for 30 minutes at mean arterial pressure (MAP) of 30 to 40 mm Hg. Resuscitation followed the shock period with crystalloids and colloids. Group NAC&DFO received additionally NAC and DFO in doses of 200 mg/kg and 65 mg/kg, respectively. The total time of the experiment was 6 hours. RESULTS Animal weight, blood loss, excised liver mass, and MAP at the end of the shock period were comparable between experimental groups. Group NAC&DFO received significantly lower volume of both crystalloids and colloids (35% and 42% less, respectively) compared to group F. Hepatocellular proliferation (proliferating cell nuclear antigen) was higher in the antioxidant group. Apoptosis, measured by caspase-3, was restored to sham group levels when NAC and DFO were administered. CONCLUSIONS Our experimental study showed that coadministration of NAC and DFO during liver hemorrhage can decrease the amounts of fluids needed for resuscitation. Moreover, the antioxidant combination restores the energy dependent apoptosis and proliferation of the hepatocytes.
Online Cage Rotor Fault Detection Using Air-Gap Torque Spectra

This paper discusses use of air-gap torque spectra as a means of identifying faults in cage rotors. Being dependent on both stator and rotor currents, the torque is very sensitive to faults in the rotor. Through a comparative study using a detailed machine model and the standard dq model, the paper shows that the characteristic frequencies generated by a particular fault are preserved even if the standard dq model is used for estimation of air-gap torque. This is validated through a practical hardware implementation for online spectrum estimation of air-gap torque using TMS320C31, where several faulted cage rotors were used for study.
Optical and NIR observations of the afterglow of GRB 020813

We present optical and near-infrared (NIR) photometry of the bright afterglow of GRB 020813. Our data span from 3 hours to 4 days after the GRB event. A rather sharp achromatic break is present in the light curve, 14 hours after the trigger. In the framework of jetted fireballs, this break corresponds to a jet half-opening angle of $1.9\degr\pm0.2\degr$, the smallest value ever inferred for a GRB. We discuss our results in the framework of currently available models, and find that they have problems in explaining the joint temporal and spectral properties, and in particular the slow decay before the break.
Age-related decreases in serum gonadotropin levels and gonadotropin-releasing hormone gene expression in the medial preoptic area of the male rat are dependent upon testicular feedback.

In the male rat, age-associated reproductive decline is thought to be due in part to diminished GnRH secretion. We tested the hypothesis that the age-related decrease in GnRH secretion is due to decreased GnRH gene expression by comparing GnRH mRNA and peptide content in the anterior forebrain of intact young and old male rats. Since sex steroids modulate GnRH secretion, we also determined hypothalamic-pituitary responsiveness to removal of testicular feedback by comparing GnRH mRNA and gonadotropin levels in intact and orchidectomized young and old rats. In an initial study, 10 20-micron coronal sections from the medial preoptic area (MPOA) were anatomically matched and compared in intact young (3-month-old) and old (24-month-old) male F344 rats (n = 5/group). In another group of young and old male rats (n = 8-12/group), animals were randomly assigned to be either orchidectomized or sham operated. Rats were killed 21 days after surgery, and comparisons were made in 12 anatomically matched sections of MPOA and 4 matched sections of diagonal band of Broca. In both studies, GnRH mRNA was quantitated by in situ hybridization, using a 35S-labeled oligodeoxynucleotide probe complementary to rat prepro-GnRH mRNA and a computerized image analysis system. In a third study, GnRH content was measured by RIA in microdissected regions of the arcuate nucleus and median eminence in intact 3- and 24-month-old male rats (n = 10 and 8, respectively). Serum LH, FSH, and testosterone (T) levels were measured by RIA in trunk blood of all animals. The number of neurons expressing the GnRH gene in the MPOA was significantly lower in sham-operated old rats (mean +/- SEM, 10.5 +/- 0.5 cells/section) than in young rats (13.7 +/- 0.7 cells/section; P less than 0.01), while cellular GnRH mRNA content was unchanged with age (103 +/- 1 vs. 103 +/- 2 grains/cell). Similar results were obtained in intact old and young rats. GnRH peptide content was significantly decreased in the arcuate nucleus of intact old (0.5 +/- 0.08 ng/mg protein) compared to young animals (2.3 +/- 0.7 ng/mg protein; P less than 0.05), with a trend toward a decrease in the median eminence of old (53 +/- 2 ng/mg protein) vs. young rats (69 +/- 7 ng/mg protein; P = 0.06). (ABSTRACT TRUNCATED AT 400 WORDS)
Butea superba Roxb. enhances Penile erection in rats

This study aimed to investigate the effects of ethanol extracts of Butea superba in increasing intracavernous pressure (ICP) in vivo. The extracts were prepared from fresh and dried root cores and fresh and dried root barks. Penile erection was induced in aged rats by electrical stimulation of the cavernous nerve. Cavernous smooth muscle relaxation was also observed in vitro in the presence of the extract, cGMP or isobutyl‐methylxanthine (IBMX) alone or the extract together with cGMP or IBMX. The dried root core extract from Phrae was the most effective in increasing the ICP. The dose‐response relationship study revealed a bell‐shape curve with the maximum effective dose at 1 mg/kg. The ICP of the control and 1 mg/kg extract‐treated animals were 45.3 ± 2.5 and 100.9 ± 14.0 mmHg, respectively. The extract, cGMP and IBMX alone induced dose dependent muscle relaxation. B. superba significantly enhanced the effects of cGMP and IBMX. The results suggest that ethanol extracts of B. superba are effective in enhancing penile erection. The dried root core extract from Phrae is the most effective part with a maximal dose of 1 mg/kg. The results also suggest that B. superba may act through cAMP/cGMP pathways. Copyright © 2006 John Wiley & Sons, Ltd.
The incidence of specific DIS/DSM‐III mental disorders: data from the NIMH Epidemiologic Catchment Area Program

ABSTRACT Incidence data are presented for the 7 most frequent specific categories of mental disorder available in the NIMH Epidemiologic Catchment Area (ECA) program (major depressive disorder; panic disorder; phobic disorder; obsessive‐compulsive disorder; drug abuse/dependence; alcohol abuse/dependence; cognitive impairment). The DSM‐III case definitions in the ECA Program are according to the implementation of the Diagnostic Interview Schedule (DIS). Rates of incidence are presented specific for age, sex, and site, and pooled smoothed curves for the relationship of age to incidence, specific for sex are shown. The 7 disorders have distinctly different relationships to sex and age of onset.
Expression of cloned herpesvirus genes. I. Detection of nuclear antigens from herpes simplex virus type 2 inverted repeat regions in transfected mouse cells

Three different recombinant plasmids containing the entire 15-kilobase L and S inverted repeat sequence of herpes simplex virus type 2 DNA have been introduced into cultured Ltk- or BSC cells by both the calcium and DEAE-dextran transfection procedures. In each case, after 24 h approximately 1% of the cells gave strongly positive nuclear staining when assayed by immunofluorescence with hyperimmune antisera made against early and immediate-early infected-cell polypeptides. The nuclear fluorescence pattern and intensity mimicked that observed within 2 to 3 h after infection of Ltk- cells with either herpes simplex virus type 1 or type 2 wild-type virus. Herpes simplex virus type 1 (KOStsB2)-infected Ltk- cells under nonpermissive conditions did not express these antigens in the nucleus. Therefore, we conclude that either one or both of the 185,000- and 110,000-molecular-weight immediate early proteins, or some other as yet unknown gene product encoded entirely within the inverted repeats, can be transiently expressed in large amounts in transfected cells in the absence of other viral genes or accompanying virion components. Permanent mouse cell lines derived from transfection with these plasmids by using the thymidine kinase coselection procedure did not express sufficient nuclear antigen to be detectable by immunofluorescence.
Examination of cutaneous T‐cell lymphoma for human herpesviruses by using the polymerase chain reaction

The etiology of cutaneous T‐cell lymphoma remains unknown, although an association with viral infection, in particular certain retroviruses and human herpesviruses, has been suggested. The purpose of this study was to examine skin biopsies of cutaneous T‐cell lymphoma for the presence of Epstein‐Barr virus, herpes simplex virus type 1 and type 2, and human herpesvirus‐6 by using the polymerase chain reaction. Lesional skin biopsies from 30 patients with cutaneous T‐cell lymphoma were studied. Control specimens included biopsies from 9 patients with lymphomatoid papulosis and 10 patients with pityriasis lichenoides et varioliformis acuta. DNA extracted from each specimen, as well as from a known positive control for each virus, was examined by using the polymerase chain reaction with viral‐specific primers. Each DNA specimen was also amplified with control primers for human β globin. The specificity of the amplified products was confirmed by Southern analysis. Neither Epstein‐Barr virus nor herpes simplex virus was detected in any of the patient specimens examined. Human herpesvirus‐6 was detected in one specimen of cutaneous T‐cell lymphoma and one specimen of lymphomatoid papulosis. These results do not support a role for any of these herpesviruses in the pathogenesis of cutaneous T‐cell lymphoma.
LIMERIC: A Linear Adaptive Message Rate Algorithm for DSRC Congestion Control

Wireless vehicle-to-vehicle (V2V) and vehicle-toinfrastructure (V2I) communication holds great promise for significantly reducing the human and financial costs of vehicle collisions. A common characteristic of this communication is the broadcast of a device's core state information at regular intervals (e.g., vehicle speed and location or traffic signal state and timing). Unless controlled, the aggregate of these broadcasts will congest the channel under dense traffic scenarios, reducing the effectiveness of collision avoidance applications that use transmitted information. Active congestion control using distributed techniques is a topic of great interest for establishing the scalability of this technology. This paper defines a new adaptive congestion control algorithm that can be applied to the message rate of devices in this vehicular environment. While other published approaches rely on binary control, the LInear MEssage Rate Integrated Control (LIMERIC) algorithm takes advantage of full-precision control inputs that are available on the wireless channel. The result is provable convergence to fair and efficient channel utilization in the deterministic environment, under simple criteria for setting adaptive parameters. This “perfect” convergence avoids the limit cycle behavior that is inherent to binary control. We also discuss several practical aspects associated with implementing LIMERIC, including guidelines for the choice of system parameters to obtain desired utilization outcomes, a gain saturation technique that maintains robust convergence under all conditions, convergence with asynchronous updates, and using channel load to determine the aggregate message rate that is observable at a receiver. This paper also extends the convergence analysis for two important cases, i.e., measurement noise in the input signal and delay in the update process. This paper illustrates key analytical results using MATLAB numerical results and employs standard NS-2 simulations to demonstrate the performance of LIMERIC in several high-density scenarios.
Neural progenitors organize in small-world networks to promote cell proliferation

Significance Synchronized activity among groups of interconnected cells is essential for diverse functions in the brain. Most studies on neuronal networks have been performed in the mature brain when chemical synapses have been established. However, less is known about networking during embryonic development. We have studied neural progenitors and found that they form gap junction-mediated small-world networks, which, via electrical depolarization, drive spontaneous calcium activity to stimulate cell proliferation. Our data underscore the critical role of intricate cell signaling during embryonic development and show that complex networks of immature cells exist in the brain before birth. Coherent network activity among assemblies of interconnected cells is essential for diverse functions in the adult brain. However, cellular networks before formations of chemical synapses are poorly understood. Here, embryonic stem cell-derived neural progenitors were found to form networks exhibiting synchronous calcium ion (Ca2+) activity that stimulated cell proliferation. Immature neural cells established circuits that propagated electrical signals between neighboring cells, thereby activating voltage-gated Ca2+ channels that triggered Ca2+ oscillations. These network circuits were dependent on gap junctions, because blocking prevented electrotonic transmission both in vitro and in vivo. Inhibiting connexin 43 gap junctions abolished network activity, suppressed proliferation, and affected embryonic cortical layer formation. Cross-correlation analysis revealed highly correlated Ca2+ activities in small-world networks that followed a scale-free topology. Graph theory predicts that such network designs are effective for biological systems. Taken together, these results demonstrate that immature cells in the developing brain organize in small-world networks that critically regulate neural progenitor proliferation.
Incidence and survival of childhood leukemia in Recife, Brazil: A population‐based analysis

Leukemia is the most common pediatric cancer with incidence rates of around 48 per million for children under 15 years of age. The median age‐adjusted incidence rate (AAIR) in children aged 0–14 years in Brazil is 53.3 per million. While overall survival rates for children with leukemia have improved significantly, data for incidence, trends, and relative survival among children and adolescents with leukemia in Recife, Brazil, remain incomplete, which hampers our analyses and provision of the best healthcare. The objective of this report is to provide that data.
The Gig Economy and Information Infrastructure

Ongoing discussions of the gig economy have focused on the critical aspect of digital mediation, and in particular the role of applications and platforms such as Uber or TaskRabbit. We extend this discussion by considering more decentralized contexts of gig economy, in which individuals do not rely on a single dominant, central intermediary, but rather exercise a higher degree of agency in arranging and aligning multiple digital platforms to support relevant work practices.We employ the concept of information infrastructure to describe the emergent configuration of heterogeneous digital platforms leveraged by digital nomads as a community of location-independent, remote workers. Using both forum analysis and in-depth interviews, we examine how the digital nomad community dynamically brings together and negotiates digital mediation in the form of an information infrastructure.
Management of Crohn's disease in adults

Guidelines for clinical practice are intended to suggest preferable approaches to particular medical problems as established by interpretation and collation of scientifically valid research, derived from extensive review of published literature. When data are not available that will withstand objective scrutiny, a recommendation may be made based on a consensus of experts. Guidelines are intended to apply to the clinical situation for all physicians without regard to specialty. Guidelines are intended to be flexible, not necessarily indicating the only acceptable approach, and should be distinguished from standards of care that are inflexible and rarely violated. Given the wide range of choices in any health care problem, the physician should select the course best suited to the individual patient and the clinical situation presented. These guidelines are developed under the auspices of the American College of Gastroenterology and its Practice Parameters Committee. Expert opinion is solicited from the outset for the document. The Committee reviews guidelines in depth, with participation from experienced clinicians and others in related fields. The final recommendations are based on the data available at the time of the production of the document and may be updated with pertinent scientific developments at a later time. (Am J Gastroenterol 2001;96:635–643. © 2001 by Am. Coll. of Gastroenterology)
Radiologic findings are strongly associated with a pathologic diagnosis of usual interstitial pneumonia.

PURPOSE To determine which clinical and radiologic findings are independently associated with a pathologic diagnosis of usual interstitial pneumonia (UIP). METHODS We recently reported, using a prospective, multicenter study of patients suspected of having idiopathic interstitial pneumonia (IIP), that a confident diagnosis of UIP made by experienced radiologists was correct in 95% of cases. In the current article, we further analyzed data from this study. Ninety-one patients were entered into the study. Clinical, physiologic, chest radiographic, and CT features were prospectively recorded, and analyzed using univariate and multivariate logistic regression analysis to compare the patients with a histologic diagnosis of UIP with those who received other pathologic diagnoses. RESULTS Fifty-four of 91 patients (59%) received a pathologic diagnosis of UIP. The following features recorded at the referring clinical centers were associated with a pathologic diagnosis of UIP on multivariate analysis: lower-lobe honeycombing on high-resolution CT (HRCT) [odds ratio, 11.45], radiographic findings consistent with UIP (odds ratio, 5.73), elevated ratio of FEV(1) to FVC (odds ratio, 4.8), and absence of smoking history (odds ratio, 0.19). On multivariate analysis of specific HRCT features recorded by four experienced chest radiologists, lower-lung honeycombing (odds ratio, 5.36) and upper-lung irregular lines (odds ratio, 6.28) were the only independent predictors of UIP. Using only these two factors, a diagnosis of UIP could be established with a sensitivity of 74%, a specificity of 81%, and a positive predictive value of 85%. CONCLUSION In patients presenting with a clinical syndrome suggestive of IIP, CT findings of lower-lung honeycombing and upper-lung irregular lines are most closely associated with a pathologic diagnosis of UIP.
CD30+ lymphoproliferative disorders

CD30 antigen, originally identified as a cell surface marker of the malignant Hodgkin and Reed-Sternberg (HRS) cells in Hodgkin’s lymphoma by the use of the Ki-1 monoclonal antibody, is a transmembrane glycoprotein member of the tumor necrosis factor (TNF) receptor superfamily. [1][1] In lymphoid