Miracle-dz/UniFAR-FTUs huggingface dataset:
Significant Factors Causing Cost Overruns in Large Construction Projects in Malaysia

Once a construction projects fails in achieving effective cost performance, it will result to cost overruns. These overruns are caused from several factors which are very important to uncover for improving the cost performance. In Malaysia, not many research works have been carried out on studying cost performance factors. Hence, this study was conducted to identify the significant factors causing cost overrun in large construction projects in Malaysia. Questionnaire for the survey was developed based on 35 common factors of cost overrun identified from literature work. These factors were grouped in 7 categories and validated by interviewing five experienced personnel of construction industry. The feedback of from the survey resulted in receiving 262 sets of completed valid responses against 400 questionnaires distributed amongst contractors, consultants and clients involved in large construction projects. The data from the questionnaire was analyzed statistically. Relative importance index method was used for hierarchal assessment of factors and found that the top 3 most significant factors of cost overrun are fluctuation of prices of material, cash flow and financial difficulties faced by contractors and poor site management and supervision. These factors belong to two categories i.e., contractor's site management and financial management category, thus improvements in these categories are paramount for controlling cost overrun in construction projects.
Probabilistic timing analysis on time-randomized platforms for the space domain

Timing Verification is a fundamental step in real-time embedded systems, with measurement-based timing analysis (MBTA) being the most common approach used to that end. We present a Space case study on a real platform that has been modified to support a probabilistic variant of MBTA called MBPTA. Our platform provides the properties required by MBPTA with the predicted WCET estimates with MBPTA being competitive to those with current MBTA practice while providing more solid evidence on their correctness for certification.
High‐Resolution CT Appearance of Miliary Tuberculosis

Objective The purpose of this study was to define the range of abnormalities and to assess the contribution of high-resolution CT (HRCT) in the evaluation of miliary tuberculosis involving the lung parenchyma. Materials and Methods The authors retrospectively reviewed HRCT scans of 11 patients with microbiologically or clinically proved miliary tuberculosis. Results In 10 patients, the most characteristic HRCT finding of miliary tuberculosis was the presence of small nodules uniformly distributed throughout both lungs. The profusion of nodules was numerous in all 10 patients. High-resolution CT scans showed both sharply and poorly defined, small nodules varying in sizes from 1 to 2 mm (n = 6), 1 to 3 mm (n = 2), and 1 to 4 mm (n = 2) in diameter. These nodules had a diffuse random distribution in the secondary lobule in all 10 patients. In 1 of the 10 patients with small nodules on HRCT, chest radiography had shown no evidence of miliary nodules in the lung. In addition to nodules, HRCT showed diffuse or localized reticular opacities superimposed on nodules in five patients, especially in the lower lung zones. In 1 of all 11 patients, ground-glass attenuation was the predominant abnormality seen on HRCT. Conclusion We believe that in the appropriate clinical situation, miliary tuberculosis may be suggested on HRCT. Moreover, in cases with no evidence of miliary nodules on the chest radiograph, HRCT scan may depict miliary nodules in the lung parenchyma.
A Transgenic Mouse Model Genetically Tags All Activated CD8 T Cells 1

Identifying and characterizing Ag-specific CD8+ T cells are central to the study of immunological memory. Although powerful strategies such as MHC tetramers and peptide-induced cytokine production assays exist for identifying Ag-specific CD8+ T cells, alternate strategies that are not dependent upon a priori knowledge of the immunodominant and subdominant antigenic epitopes, as well as the MHC background of the animal are of obvious utility. In this study, we present a transgenic mouse model that uses Cre-loxP recombination to permanently mark all activated CD8+ T cells with β-galactosidase. We used the lymphocytic choriomeningitis virus infection model to track the dynamics of the antiviral CD8+ T cell responses. We show that in this transgenic mouse model system, all of the antiviral effector and memory CD8+ T cells are contained within the β-gal-marked CD8+ T cell population.
Geldanamycin, a heat shock protein 90‐binding agent, disrupts Stat5 activation in IL‐2‐stimulated cells

The 90‐kDa heat shock protein (Hsp90) is the most abundant molecular chaperone in eukaryotic cells. Hsp90 plays a critical role in regulating signal transduction pathways that control cell proliferation since its chaperone function is restricted to a subset of proteins including some signal molecules. Improper function of these proteins can be induced by an anti‐tumor agent geldanamycin (GA) which is the specific inhibitor of Hsp90. In this study, it was demonstrated that GA interferes with IL‐2‐stimulated proliferation of murine CTLL‐2 cells. As to the signaling mechanisms underlying this inhibitory effect, we discovered GA disrupts the IL‐2‐stimulated activation and phosphorylation of the transcription factor Stat5, indicating the proper function of Hsp90 is indispensable for Stat5 activation. This conclusion is validated by the observation that Hsp90 interacts with Stat5 in the immunoprecipitation assay and GA interrupts their interaction. Furthermore, by constructing deletion mutants, we identified the c‐terminal half of Stat5 coiled‐coil region is responsible for binding with Hsp90. J. Cell. Physiol. 198: 188–196, 2004© 2003 Wiley‐Liss, Inc.
Age, self-efficacy, and change in patients' adjustment to cancer.

OBJECTIVES The purpose of this secondary analysis was to investigate cancer patients' self-care self-efficacy and measures of adjustment over time, as well as the role of self-care self-efficacy with measures of adjustment. The primary study was a longitudinal study of cancer patients and family members' adjustments. MATERIALS AND METHODS Three hundred seven cancer patients at all stages of cancer completed study instruments on one occasion; 181 completed the instruments 4 months later; and 124, 8 months later. Instruments included the Strategies Used by Patients to Promote Health (SUPPH) to measure self-care self-efficacy, the Functional Assessment of Cancer Treatment (FACT) to measure quality of life, the Profile of Mood States (POMS) to measure patients' mood disturbances, and the Symptom Distress Scale (SDS) to measure patients' concerns. RESULTS Using analysis of variance, a series of one-way repeated measures used to investigate changes in cancer patients' self-care self-efficacy and measures of adjustment revealed significant decreases in patients' self-care self-efficacy (P = .01) and quality of life (P = .001) over time. Patients' symptoms and mood disturbances did not significantly change over time. The role of self-care self-efficacy with measures of adjustment was investigated using canonical correlations. For the predictor variables, subscores for coping and enjoying life on the SUPPH showed the strongest loadings, 0.83 and 0.94, respectively. On the dependent variables, the FACT was by far the most important variable, with a loading of 0.92. CONCLUSIONS Results demonstrate that without intervention, cancer patients' measures of self-efficacy and adjustment decrease over time, and patients' self-efficacy influences their adjustment. Psychosocial interventions have been designed to increase self-efficacy and to enhance adjustment. Longitudinal study of efficacy-enhancing interventions is needed.
Expression of Tumor Suppressor Gene Product p14ARF in Endometrioid Adenocarcinoma of the Uterine Corpus

Summary:p14ARF activates p53 by inhibiting MDM2 expression and arrests the cell cycle in G1 and G2/M. Abnormal p14ARF expression has been reported in various human cancers. This study investigated p14ARF expression in endometrioid adenocarcinoma of the uterine corpus in an attempt to clarify its correlation with other cell cycle-regulators and clinicopathologic parameters. The specimen studied consisted of 124 endometrioid adenocarcinomas, 20 normal endometria, and 20 endometrial hyperplasias. Immunohistochemical staining of formalin-fixed and paraffin-embedded tissues was performed using a Catalyzed Signal Amplification System. Cells with >5% positive staining were classified as positive for p14ARF. A staining score of 1 was adopted when the percentage of positive nuclei was <5%, a score of 2 when it was 5 to 50%, and a score of 3 when it was >50%. In normal endometrium, the frequency of positive staining in the proliferative phase and secretory phase was 50% (4/8) and 58.3% (7/12), with staining scores of 1.8±0.9 and 1.6±0.5, respectively. The frequency of staining in simple hyperplasia (SH), complex hyperplasia (CH), and complex atypical hyperplasia (CAH) was 88.9% (8/9), 25% (1/4), and 42.9% (3/7), respectively; the staining scores were 1.9±0.3, 1.3±0.5, and 1.4±0.5, respectively. Among endometrioid adenocarcinomas, the frequency of staining of well-differentiated (G1), moderately differentiated (G2), and poorly differentiated (G3) adenocarcinomas was 69% (49/71), 64% (16/25), and 42.9% (12/28) respectively, with staining scores of 2.1±0.8, 2±0.9, and 1.8±1, respectively. Thus expression levels of p14ARF were higher in G1 tumors than in normal endometria or endometrial hyperplasias, and the frequency of its staining in endometrioid carcinomas was inversely correlated with histologic grade. The staining score for endometrioid adenocarcinomas also was inversely correlated with the labeling index (LI) of Ki-67, but not with that of cyclin A, cyclin D1, cyclin E, cdk2, p27, p53, or other clinicopathologic parameters. In conclusion, p14ARF expression correlated with histologic grade and Ki-67, but not other prognostic factors in endometrioid adenocarcinoma. Long-term follow-up studies are needed to analyze the significance of p14ARF expression in these tumors.
Isolation and Characterization of the Human Gene Homologous to the Drosophila Headcase (hdc) Gene in Chromosome Bands 6q23-q24, a Region of Common Deletion in Human Pancreatic Cancer

Deletions of the long arm of chromosome 6 (6q) are one of the most common chromosomal abnormalities in multiple human malignancies. Previously, we have identified three commonly deleted regions on 6q (6q21, 6q23-q24, and 6q26) in pancreatic cancer by loss of heterozygosity studies, suggesting the presence of one or more tumor suppressor genes on this chromosome arm. Using a combination of database search and cDNA library screening, we successfully isolated a transcript from 6q24. This mRNA encodes a protein consisting of 543 amino acids with homology to the Drosophila headcase (hdc) gene and, thus, is designated as hHDC. Northern analysis identified a ubiquitously expressed 5.6-kb transcript. Seventeen (81%) of 21 pancreatic cancer cell lines and four (80%) of five renal cell carcinoma cell lines showed low level expression, suggesting that the hHDC gene may play an important role in some human cancers.
Statistical Skimming of Feature Films

We present a statistical framework based on Hidden Markov Models (HMMs) for skimming feature films. A chain of HMMs is used to model subsequent story units: HMM states represent different visual-concepts, transitions model the temporal dependencies in each story unit, and stochastic observations are given by single shots. The skim is generated as an observation sequence, where, in order to privilege more informative segments for entering the skim, shots are assigned higher probability of observation if endowed with salient features related to specific film genres. The effectiveness of the method is demonstrated by skimming the first thirty minutes of a wide set of action and dramatic movies, in order to create previews for users useful for assessing whether they would like to see that movie or not, but without revealing the movie central part and plot details. Results are evaluated and compared through extensive user tests in terms of metrics that estimate the content representational value of the obtained video skims and their utility for assessing the user's interest in the observed movie.
A comparative Monte Carlo study on 6MV photon beam characteristics of Varian 21EX and Elekta SL-25 linacs

Background: Monte Carlo method (MC) has played an important role in design and optimization of medical linacs head and beam modeling. The purpose of this study was to compare photon beam features of two commercial linacs, Varian 21EX and Elekta SL-25 using MCNP4C MC code. Materials and Methods: The 6MV photon beams of Varian 21EX and Elekta Sl25 linacs were simulated based on manufacturers provided information. Photon energy spectra and absolute absorbed dose values were calculated for field sizes of 10×10 and 20×20 cm 2 . Also,
Self-Organization of a Small World by Topic

In this paper, we demonstrate how small worlds – i. e. , highly clustered networks with small diameter – of peers can organize themselves in an ontology-based P2P knowledge management system. To that end, we provide rewiring strategies to build a network in which peers form clusters where they are connected to other peers interested in similar topics. These strategies only rely on the local knowledge of each peer and on the notion of similarity derived from the relationships of entities the ontology. We evaluate these algorithms and show that a small world of topically coherent clusters actually emerges, and that this improves the performance of query operations.
Long-term prognosis of idiopathic nephrotic syndrome in children

Abstract Background: To investigate the demographic, clinical and laboratory data of the children with idiopathic nephrotic syndrome (INS), and to determine prognostic factors that affect the clinical outcome of the patients. Methods: Medical charts of 372 patients diagnosed to have INS and followed up at least 5 years between January 1990 and December 2008 were evaluated, respectively. After initial demographic, clinical and laboratory findings of the patients were documented, therapeutic protocols, prognosis and prognostic factors were investigated. Results: 299 of the patients (80.4%) were steroid responsive and 73 (19.6%) were not. Focal segmental glomerulosclerosis (FSGS) was observed in 57%, minimal change disease (MCD) in 20.6% and diffuse mesengial proliferation in 21.9% renal biopsy materials. Steroid sensitivity was higher in patients with MCD and under the age of five years. Resistance to steroids was higher in children with FSGS. Complete remission was achieved in 96% of patients who were sensitive to steroids and in 46.6% who were resistant. 15% of patients who were steroid resistant developed chronic kidney disease (CKD). Conclusion: Intercurrent infections and response to steroid therapy are the most important factors affecting the prognosis of the disease.
Predicting Chronic Posttraumatic Stress Disorder in Bereaved Relatives

The objectives of the present study were to examine the prevalence of posttraumatic stress disorder (PTSD) and to identify predicative risk factors for PTSD in bereaved people after a terminal illness. Fifty-four persons (mean age 60 years) participated in the study. Demographic, peritraumatic, and psychosocial factors were assessed in order to identify variables that affected PTSD severity. Six months after the loss, 21.6 % of the subjects had PTSD, an 8.6 % decrease from PTSD measured one month after the loss. Intake of medicine after the loss, place of death, not having a close intimate, negative affectivity, and the A2 criterion predicted 65 % of PTSD severity. A considerable number of the bereaved were still at great risk for developing PTSD six months after loss.
ITERATION OF MEROMORPHIC FUNCTIONS 153 duced by Douady and Hubbard

4. The Components of the Fatou set 4.1. The types of domains of normality 4.2. The classification of periodic components 4.3. The role of the singularities of the inverse function 4.4. The connectivity of the components of the Fatou set 4.5. Wandering domains 4.6. Classes of functions without wandering domains 4.7. Baker domains 4.8. Classes of functions without Baker domains 4.9. Completely invariant domains
MOLECULAR ASPECTS OF ARSENIC STRESS

Arsenic produces a variety of stress responses in mammalian cells, including metabolic abnormalities accompanied by growth inhibition and eventually apoptosis. Morphological alterations in cells exposed to arsenic often suggest underlying disruption of cytoskeletal structural elements responsible for cellular integrity, shape, and locomotion. However, specifics of the ultrastructural changes produced by arsenic remain poorly understood. Various tissues and organs differ in their sensitivity to arsenic, with the liver and skin being the most studied. Characteristic skin pathology related to arsenic exposure ranges from hyperkeratotic lesions to squamous-cell carcinomas. However, molecular events in the arsenic-exposed skin still remain to be elucidated. Although mutagenicity of arsenic has not been unequivocally established, recent evidence supports the view that oncogenic mutations do occur, and that only selected enzymes related to DNA replication and repair are affected by arsenic. Sensitivity of the mitotic spindle to arsenic, particularly its organic compounds, underlies the well-documented chromosomal aberrations in arsenic-exposed populations. Arsenite-induced stress at the molecular level shares many features with the heat shock response. This includes the differential sensitivity of the stress signal pathway elements to the magnitude of the stress, stressor-specific activation of the response elements, and the protective role of the heat shock response. Oxidative stress, the central component of heat shock response, is typical of arsenic-related effects that are, in fact, regarded as the chemical paradigm of heat stress. Similar to heat stress, arsenite induces heat shock proteins (HSPs) of various sizes. The signal cascade triggered by arsenitelike heat stress induces the activity of the mitogen-activated protein (MAP) kinases, extracellular regulated kinase (ERK), c-jun terminal kinase (JNK) , and p38. Through the JNK and p38 pathways, arsenite activates the immediate early genes c-fos, c-jun, and egr-1, usually activated by various growth factors, cytokines, differentiation signals, and DNA-damaging agents. Like other oxygen radical-producing stressors, arsenic induces nitric oxide production at the level of transcriptional activation along with induction of poly(ADP)ribosylation, NAD depletion, DNA strand breaks, and formation of micronuclei. This review presents an overview of current research on molecular aspects of arsenic stress with an emphasis on the tissue-specific events in humans. It deals with current progress on the understanding of the signal transduction pathways and mechanisms underlying the sensitivity of various species, organs, and tissues to arsenic.
Effects of Carbon-Ion Beams on Human Pancreatic Cancer Cell Lines That Differ in Genetic Status

The relative biologic effectiveness (RBE) of carbon-ion beams at 3 different linear energy transfer (LET) values (13, 50, and 80 keV/&mgr;m) accelerated by the Heavy Ion Medical Accelerator in Chiba on human pancreatic cancer cell lines differing in genetic status was determined. The RBE values were calculated as D10, the dose (Gy) required to reduce the surviving fraction to 10%, relative to X-rays. We also investigated apoptosis and the relationship between D10 and the cell cycle checkpoint using morphologic examination and flow cytometry analysis, respectively. The RBE values calculated by the D10 values ranged from 1.16 to 1.77 for the 13-keV/&mgr;m beam and from 1.83 to 2.46 for the 80-keV/&mgr;m beam. A correlation between the D10 values of each cell line and intensity of G2/M arrest was observed. In contrast, LET values did not clearly correlate with induction of apoptosis. These results suggest that carbon-ion beam therapy is a promising modality. Elucidation of the mechanisms of G2/M arrest and apoptosis may provide clues to enhancing the effects of radiation on pancreatic cancer.
Indomethacin Prophylaxis for Heterotopic Ossification after Acetabular Fracture Surgery Increases the Risk for Nonunion of the Posterior Wall

Objectives: To determine if indomethacin has a positive clinical effect for the prophylaxis of heterotopic ossification (HO) after acetabular fracture surgery. To determine whether indomethacin affects the union rate of acetabular fractures. Design: Prospective randomized double-blinded trial. Setting: Level 1 regional trauma center. Patients: Skeletally mature patients treated operatively for an acute acetabular fracture through a Kocher–Langenbeck approach. Intervention: Patients were randomly allocated to 1 of 4 groups comparing placebo (group 1) to 3 days (group 2), 1 week (group 3), and 6 weeks (group 4) of indomethacin treatment. Main Outcome Measurements: Factors analyzed included the overall incidence, Brooker class and volume of HO, radiographic union of the acetabular fracture, and pain. Patients were followed clinically and radiographically at 6 weeks, 3 months, 6 months, and 1 year. Serum levels of indomethacin were drawn at 1 month to assess compliance. Computed tomographic scans were performed at 6 months to assess healing and volume of HO. Results: Ninety-eight patients were enrolled into this study, 68 completed the follow-up and had the 6-month computed tomographic scan, and there was a 63% compliance rate with the treatment regimen. Overall incidence of HO was 67% for group 1, 29% for group 2 (P = 0.04), 29% for group 3 (P = 0.019), and 67% for group 4. The volume of HO formation was 17,900 mm3 for group 1, 33,800 mm3 for group 2, 6300 mm3 for group 3 (P = 0.005), and 11,100 mm3 for group 4. The incidence of radiographic nonunion was 19% for group 1, 35% for group 2, 24% for group 3, and 62% for group 4 (P = 0.012). Seventy-seven percent of the nonunions involved the posterior wall segment. Pain visual analog scores (VASs) were significantly higher for patients with radiographic nonunion (VAS 4 vs. VAS 1, P = 0.002). Conclusions: Treatment with 6 weeks of indomethacin does not appear to have a therapeutic effect for decreasing HO formation after acetabular fracture surgery and appears to increase the incidence of nonunion. Treatment with 1 week of indomethacin may be beneficial for decreasing the volume of HO formation without increasing the incidence of nonunion. Level of Evidence: Therapeutic Level II. See Instructions for Authors for a complete description of levels of evidence.
Cracking Hill Ciphers with Goodness-of-Fit Statistics

Abstract The Hill cipher, also known as matrix encryption, is a polygraphic substitution cipher, developed by the mathematician Lester S. Hill in 1929. While various attacks had been known on the Hill cipher, the ciphertext-only attack without assumptions about the encryption matrix or probable plaintext words was introduced only recently by Bauer and Millward. They obtained high efficiency of attack by recovering the decryption matrix row by row rather than all rows at once. In this paper, we extend their ciphertext-only attack in two ways. First, we present a better scoring system for cryptanalysis based on the goodness-of-fit statistics. Specifically, we reduce the average number of candidate rows from 24.83 to 7.00 for 3 × 3 matrix and from 4027.78 to 1220.38 for 4 × 4 matrix. Second, we show how to apply our attacks to the Hill cipher without knowing the numeric equivalents of the letters of the plaintexts.