Miracle-dz/UniFAR-FTUs huggingface dataset:
ADIPONECTIN : Adiponectin decreases TH 2 inflammation in mouse models of asthma and decreases insulin resistance in mouse models of diabetes

INFORMATION FOR CATEGORY 1 CME CREDIT Credit can now be obtained, free for a limited time, by reading the review articles in this issue. Please note the following instructions. Method of Physician Participation in Learning Process: The core material for these activities can be read in this issue of the Journal or online at the JACI Web site: www.jacionline. org. The accompanying tests may only be submitted online at www.jacionline. org. Fax or other copies will not be accepted. Date of Original Release: November 2008. Credit may be obtained for these courses until October 31, 2010. Copyright Statement: Copyright 2008-2010. All rights reserved. Overall Purpose/Goal: To provide excellent reviews on key aspects of allergic disease to those who research, treat, or manage allergic disease. Target Audience: Physicians and researchers within the field of allergic disease. Accreditation/Provider Statements and Credit Designation: The American Academy of Allergy, Asthma & Immunology (AAAAI) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. The AAAAI designates these educational activities for a maximum of 1 AMA PRA Category 1 Credit . Physicians should only claim credit commensurate with the extent of their participation in the activity. List of Design Committee Members: Author: Angela Haczku, MD, PhD Activity Objectives 1. To understand the unique structure of soluble pattern recognition receptors (collectins), their localization, and their functional versatility. 2. To understand the role of the lung collectins in pathogen recognition, airway defenses, and airway inflammation. Recognition of Commercial Support: This CME activity is supported by an educational grant from Merck & Co., Inc. Disclosure of Significant Relationships with Relevant Commercial Companies/Organizations: Angela Haczku has received grants from the National Institutes of Health, Sepracor, Centocor, and GlaxoSmithKline.
The impact of fire and dogs on Koalas at Port Stephens, New South Wales, using population viability analysis

The Port Stephens Koala Phascolarctos cinereus population has been regarded as one of the strongholds for Koalas in New South Wales. This study applied population viability analysis to investigate the impact of fire and predation by dogs on the viability of the local population. The rapid decline of the modelled Koala population under basic assumptions throws the assumed security of such large populations into question. In all the modelled management scenarios, reducing mortality had more influence than any other factor. Reducing the severity and frequency of large catastrophic fires improved the probability of survival for the population, though the modelled population size still declined sharply. Any management action to improve Koala survival must be accompanied by a reduction in mortality from dog attacks. Fires and dogs will have an ever greater impact on Koala populations as coastal forests become more fragmented and isolated by urban development, and their combined control will be needed to complement land-use planning measures to address habitat loss and fragmentation.
and Adolescent Communication About Sex on Condom Use − Effects of Family Functioning and Parent Predicting Condom Use Attitudes , Norms , and Control Beliefs in Hispanic Problem Behavior Youth : The

Hispanic problem behavior youth are at an increased risk of engaging in HIV risk behaviors, including low condom use. However, relatively little research has examined factors that affect condom use in this population. Although research indicates that family processes, such as higher levels of family functioning and open parent–adolescent communication about sex, and condom use attitudes, norms, and control beliefs as depicted by the theory of planned behavior have an effect on condom use behaviors, the combination of the two factors has received minimal attention. The purpose of this study was to examine the effect of family functioning on condom use intentions and behaviors through communication about sex and condom use attitudes, parental norms, and control beliefs. A cross-sectional study of 171 predominately male (73.1%) sexually active Hispanic problem behavior adolescents (mean age = 14.88 years) was conducted. Structural equation modeling was used to test the study hypothesis. Findings largely support the overall model and suggest that family functioning had an indirect effect on condom use intention and behavior through communication about sex, condom use attitudes, and control beliefs. Family functioning, however, did not have an indirect effect on condom use intention and behavior through communication about sex and parental norms. Implications for prevention science and future research are discussed.
Nabors An In-Depth Exploration Drug Use and Intimate Partner Violence Among College Students :

College students experience an extremely high level of violence among intimate partners during their college careers, with prevalence rates ranging between 20% and 50%. Because intimate partner violence (IPV) among college students is such a widespread problem, it is important to understand the factors that contribute to this type of abuse. Studies using a variety of samples demonstrate that drug use is one such factor. However, research to date fails to identify specific types of drugs linked to college students’ use of violence against intimates. In an attempt to fill this void, this exploratory study uses data from the Relationship Characteristics Study, which was conducted in 2001 and includes a sample of 1,938 college students, to provide a more comprehensive understanding of the relationship between college students’ drug use and IPV perpetration than the current literature allows.
LEIOMYOMAS PREVALENCE IN AFRICAN AMERICANS

Department of Obstetrics and Gynecology, Georgia Regents University, Medical College of Georgia, Augusta, Georgia 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 Objective: To provide a detailed summary of current scientific knowledge on uterine fibroids (leiomyomas) in vitro and in in vivo animal models, as well as to postulate the potential role of vitamin D3 as an effective, inexpensive, safe, long-term treatment option for uterine fibroids. Design: PubMed search articles were used to identify the most relevant studies on uterine fibroids, as well as effects of vitamin D3 on uterine fibroid cells and fibroid tumor growth in in vivo animal models. Setting: University research laboratory. Patient(s): Not applicable. Intervention(s): None. Main Outcome Measure(s): Not applicable. Result(s): Despite numerous publications available on uterine fibroids, information about the role that vitamin D3 plays in the regulation of uterine fibroids is limited. Most of the recent vitamin D3–related studies on uterine fibroids were published from our group. Recent studies have demonstrated that vitamin D deficiency plays a significant role in the development of uterine fibroids. Our recent studies have demonstrated that vitamin D3 reduces leiomyoma cell proliferation in vitro and leiomyoma tumor growth in in vivo animal models. These results postulate the potential role of vitamin D3 for an effective, safe, nonsurgical medical treatment option for uterine fibroids. Conclusion(s): This article reviews human and animal studies and uncovers new possibilities for understanding the vitamin D–based
Sleep Disorders in Climacteric Women of the Northeastern City of Brazil

Introduction: One of the stages of women's lives is the climacteric, a period often accompanied by emotional and physical signs and emotional, which may negatively influence the quality of life. Among the typical climacteric symptoms are sleep disorders, often overlooked by professionals who assist the woman. Objective: Identifying factors related to sleep disorders in cliamcteric women, in the city of Cajazeiras, Paraiba, Brazil. Method: A cross-sectional survey conducted in the city of Cajazeiras, with 411 women 40-60 years old, belonging to the Family Health Units in the urban area, included in the sample after reading and signing the Informed Consent. Data were collected through interviews with structured questionnaire and analyzed using the Statistical Package for the Social Sciences (SPSS). The exposure variables were: meals/day, sedentary lifestyle, smoking, alcohol consumption, overweight/obesity, hypertension and diabetes, which were dichotomized to enable the calculation of the odds ratio ( OR ) with CI 95% and p < 0.05. The research project was approved by the Research Ethics Committee of the State University of Paraiba, Protocol 0462.0. 133.000-11. Results: The average age of the study population was 49.73 (± 5.799). The average number of years studied was 7.72 (± 4.76). Regarding per capita income, the average was 0739 (± 0.811). The sleep complaints prevailed in 65.5% (n = 269). By the findings, it was realized that the variables associated with sleep disorders were: alcoholism [ p = 0.014; OR : 1845 (CI 1085-3139)]; presence of illnesses [ p = 0.004; OR : 1796 (CI 1185-2725)] and hypertension [p = 0.005; OR : 1827 (CI 1164-2868). Conclusion: The high prevalence of sleep disorders, the unfavorable socio-demographic conditions and morbid factors found confirm the strong impact of menopause on women's lives. We realize the need to investigate other risk factors for sleep disorders, associated with socio-demographic data and intrinsic factors, regarding climacteric.
Effect of aqueous extracts of allelopathic plants on growth and biomass of wheat and weeds

Weeds infestation is one of the yield limiting factors in Pakistan. Although chemical control of weeds is effective but may cause crop damage, resistance development of weeds and animal and human health problems. Therefore a field experiment was conducted at Agronomy Research Farm, The University of Agriculture, Peshawar-Pakistan to evaluate the effect of allelopathic plants water extract (Eucalyptus camaldulensis, Lantana camara, Parthenium hysterophorus and Sorghum halepense) and concentration of extracts (1:4, 1:5 and 1:6) on wheat and weed biomass during winter season 2015-16. The experiment was laid out in randomized complete block design using four replications. Plot size was 3m x 1.8m having 6 rows 30cm apart. One control plot in each replication was maintained. The plant water extracts in respective concentrations were sprayed one week after sowing with knapsack sprayer. The results indicated that plots that received Sorghum halepense water extract resulted in lower weed density (43 m ), fresh (102.4 g m) and dry (19.9 g m) weeds biomass. Similarly application of Sorghum halepense water extract in wheat crop increased emergence m (89), leaf area tiller (100.54 cm), leaf area index (3.0), plant height (85.68 cm), biological yield (8717 kg ha) and harvest index (38.34%). Among different plant water extracts concentration of 1:4 remarkably reduced weeds density (35 m), fresh (74.6 g m) and dry (15.8 g m) weeds biomass, while application of different plant water extracts at 1:6 concentration produced maximum emergence m (90), leaf area tiller (102.26 cm), leaf area index (3.1), plant height (89.03 cm), biological yield (9071 kg ha) and harvest index (38.31%). Thus spray of Sorghum halepense water extract at 1:6 concentration performed better and is recommended for weeds suppression and enhancing wheat biomass in the study area.
Empirical Relationships of Phytomacrofaunal Abundance to Plant Biomass and Macrophyte Bed Characteristics

The abundance of phytophilous invertebrates was measured in 13 macrophyte beds and was related, using multiple regression analysis, to the biomass of macrophytes among which the invertebrates were collected, the average plant biomass growing per unit lake area, water and organic matter content of the sediments, total phosphorus concentration in the water, rooting depth of the macrophyte bed, and sampling date. Quantitative analyses are presented for chironomids, cladocerans, cyclopoid copepods, gastropods, water mites (Hydracarina), ostracods, and trichopterans. R2 values for the regression equations ranged from 0.43 to 0.81. The abundance of invertebrates was best related to the biomass of separate plant species, but equations based only on total plant biomass sometimes had equivalent R2 values, in general, the abundance of phytophilous invertebrates was positively related to areal plant biomass, sediment organic matter, and lake trophic status and negatively related to depth. The abundance of phytophilo.
Amyotrophic lateral sclerosis , gene deregulation in the anterior horn of the spinal cord and frontal cortex area 8 : implications in frontotemporal lobar

Transcriptome arrays identifies 747 genes differentially expressed in the anterior horn of the spinal cord and 2,300 genes differentially expressed in frontal cortex area 8 in a single group of typical sALS cases without frontotemporal dementia compared with age‐matched controls. Main up‐regulated clusters in the anterior horn are related to inflammation and apoptosis; down‐regulated clusters are linked to axoneme structures and protein synthesis. In contrast, up‐regulated gene clusters in frontal cortex area 8 involve neurotransmission, synaptic proteins and vesicle trafficking, whereas main down‐regulated genes cluster into oligodendrocyte function and myelin‐related proteins. RT‐qPCR validates the expression of 58 of 66 assessed genes from different clusters. The present results: a. reveal regional differences in de‐regulated gene expression between the anterior horn of the spinal cord and frontal cortex area 8 in the same individuals suffering from sALS; b. validate and extend our knowledge about the complexity of the inflammatory response in the anterior horn of the spinal cord; and c. identify for the first time extensive gene up‐regulation of neurotransmission and synaptic‐related genes, together with significant down‐regulation of oligodendrocyte‐ and myelin‐related genes, as important contributors to the pathogenesis of frontal cortex alterations in the sALS/frontotemporal lobar degeneration spectrum complex at stages with no apparent cognitive impairment.
IMPrECISE: Good-is-good-enough data integration

IMPrECISE is an XQuery module that adds probabilistic XML functionality to an existing XML DBMS, in our case MonetDB/XQuery. We demonstrate probabilistic XML and data integration functionality of IMPrECISE. The prototype is configurable with domain knowledge such that the amount of uncertainty arising during data integration is reduced to an acceptable level, thus obtaining a "good is good enough" data integration with minimal human effort.
Rho‐kinase Gene Polymorphisms in Related Disease States

The Rho‐kinase (ROCK) family members, consisting of ROCK1 and ROCK2, are serine‐ threonine kinases that are activated by small GTPases. ROCKs play central roles in the actin cytoskeleton organization and regulate a wide range of fundamental cellular func‐ tions, such as apoptosis, inflammatory responses, cell contractility, adhesion, migration, motility, proliferation, phagocytosis, and apoptosis. Accumulating evidence from basic and clinical studies supports the concept that ROCK plays important roles in many dis‐ eases and could be a potential therapeutic target for diverse disorders, including cardio‐ vascular, neurologic, metabolic, autoimmune disorders, and cancers. Although there are only limited numbers of published studies related to ROCK polymorphisms in humans, the contribution of the genetic studies related to ROCK variants to the disease states is emerging. Identifying mutated genes or associated polymorphisms and evaluating their potential risks are important steps for understanding the genetic components and patho‐ genesis of diseases. Identification of functional mutations or polymorphisms could poten ‐ tially help in the development of novel ROCK‐specific therapies in related disease states. to a possible gender‐related modulation by the ROCK1 gene in colorectal cancer
Running Head : 1 Identification of an Epiallele of RAV 6 in rice 2 3 Corresponding

71 Heritable epigenetic variants of genes, termed epialleles, can broaden genetic and phenotypic 72 diversity in eukaryotes. Epialleles may also provide a new source of beneficial traits for crop 73 breeding, but very few epialleles related to agricultural traits have been identified in crops. 74 Here, we identified Epi-rav6, a gain-of-function epiallele of rice RELATED TO ABI3 AND 75 VP1 6 (RAV6), which encodes a B3 DNA binding domain-containing protein. The Epi-rav6 76 plants show larger lamina inclination and smaller grain size; these agronomicially important 77 phenotypes are inherited in a semi-dominant manner. We did not find nucleotide sequence 78 variation of RAV6. Instead, we found hypomethylation in the promoter region of RAV6, which 79 caused ectopic expression of RAV6 in Epi-rav6 plants. Bisulfite analysis revealed that 80 cytosine methylation of 4 CG and 2 CNG loci within a continuous 96-bp region plays 81 essential roles in regulating RAV6 expression; this region contains a conserved MITE 82 transposon insertion in cultivated rice genomes. Overexpression of RAV6 in wild type 83 phenocopied the Epi-rav6 phenotype. The brassinosteroid (BR) receptor 84 BRASSINOSTEROID-INSENSITIVE1 (BRI1) and BR biosynthetic genes EBISU DWARF 85 (D2), DWARF11 (D11), and BR-DEFICIENT DWARF1 (BRD1) were ectopically expressed in 86 Epi-rav6 plants. Also, treatment with a BR biosynthesis inhibitor restored the leaf angle 87 defects of Epi-rav6 plants. This indicates that RAV6 affects rice leaf angle by modulating BR 88 homeostasis and demonstrates an essential regulatory role of epigenetic modification on a key 89 gene controlling important agricultural traits. Thus, our work identifies a novel rice epiallele, 90 which may represent a common phenomenon in complex crop genomes. 91
School Students Gender and Age Differences in Self-Reported Aggression of High

The purpose of the study was to (a) investigate gender and age differences in physical aggression, verbal aggression, anger, and hostility, and (b) examine the discriminatory power of the Greek version of the Aggression Questionnaire (GAQ) with high school students. The sample of the study consisted of 658 high school students (321 boys and 337 girls), with an age range from 13 to 17 years (M = 15.3, SD = 1.5). The students completed the Aggression Questionnaire adapted to Greek. Regarding gender, the overall correct identification rate in the discriminant analysis showed that 73.3% of the cases were correctly classified. In addition, the results indicated that physical aggression declined with age and that, compared to boys, girls of higher grades apply more indirect forms of aggression, such as anger and hostility. The findings of the study provide important information regarding the expression of aggressive behavior during adolescence.
Diagnosis of diabetes was made using American Diabetes Association criteria for diagnosis of diabetes

Diabetic nephropathy (DN) is the leading cause of end-stage renal disease all over the world. India has a high incidence and prevalence of diabetes and >30% have nephropathy. Recently, a histological classification has been proposed. This study analyzed the renal histology in 114 diabetic patients with renal dysfunction. Nearly 75% of patients had DN. Fifty five (63.95%) were males. Mean duration of diabetes was 7.04 ± 4.9 years. Mean serum creatinine in study group was 5.2 ± 2.9 mg/dl, with mean estimated glomerular filtration rate of 23.43 ± 21.48 ml/min/1.732 m2. Forty eight patients (55.81%) had diabetic retinopathy (DR); prevalence of DR was more in patients who had diabetes for > 10 years than patients who had diabetes for <6 years (P = 0.022). The most common histological class was Class IV observed in 37 (43.02. %) cases, Class III DN in 24 (27.90%) cases, Class IIa and Class IIb in 11 (12.79%) cases each and Class I DN in 3 (3.48%) cases. Higher histological class was associated with higher proteinuria, lower glomerular filtration rate (P < 0.001) and was more likely to be associated with retinopathy (P = 0.012) and hypertension (P = 0.0003) but did not correlate with duration of diabetes (P = 0.85). There was a poor correlation between retinopathy and DN. Biopsy helps to stage the renal lesions in diabetics with renal dysfunction.
MODELING THE EFFECT OF SOIL AMENDMENTS (COMPOSTS) ON WATER BALANCE AND WATER QUALITY

The nutrients loading from agricultural and urban areas have increased nutrient concentrations, particularly phosphoms, at the Everglades National Park (ENP). The soils in the region are mainly crushed limestone with low water holding capacity, high permeability, low organic matter, and low fertility. The Everglades-Ago-Hydrology Model (EAHM) has been developed to evaluate the impact of agricultural practices on crop production, water balance and the fate and transport of nutrients and pesticides. Considering the poor soil quality, the model simulation test indicated that the application of 90 to 134 ha-' of compost annually will result in an increase in soil-water content, crop yield, and reduced water seepage below the root zone, thus reducing the potential for nitrogen and Atrazine to leach into groundwater.
Development of a quantitative real time PCR assay for Sapovirus in under-five-year old children in Hospital

Gastroenteritis is a common disease in children, characterized by diarrhea, vomiting, abdominal pain, and fever. Sapovirus (SaV) is a causative agent of acute gastroenteritis although it causes milder illness than rotavirus and norovirus. There is high variability in analytical performance of quantitative PCR-based assays amongst clinical laboratories. This study develops a RT real-time PCR method to detect SaV in fecal specimens collected from under-five-year-old children with acute gastroenteritis. 15 out of 137 (10.9%) episodes of acute gastroenteritis were associated with SaV genomic detection with median viral load 6.6(log10) ± 7.1(log10) genomes/mg fecal specimens. Page 1 of 21 C an . J . M ic ro bi ol . D ow nl oa de d fr om w w w . n rc re se ar ch pr es s. co m b y A T H A B A SC A U N IV o n 12 /0 6/ 16 Fo r pe rs on al u se o nl y. T hi s Ju st -I N m an us cr ip t i s th e ac ce pt ed m an us cr ip t p ri or to c op y ed iti ng a nd p ag e co m po si tio n. I t m ay d if fe r fr om th e fi na l o ff ic ia l v er si on o f re co rd . There was significant difference in detection rate between male and female (9.48% (13/15) vs. 1.46% (2/15), p = 0.0232). Among the 15 SaV-positive cases, 6 were also positive for rotavirus. Viral RNA recovery rate ranged from 46 to 77% in manual RNAzol protocol and 31 to 90% in automated Maxwell. We also studied whether human genomic DNA influence the sensitivity of the assay: its presence caused a decrease in PCR sensitivity. The development of a laboratory designed Real-Time PCR TaqMan assay for quantitative detection of SaV and the optimization and standardization of this assay, using stool of children with acute gastroenteritis, are described.