Miracle-dz/UniFAR-FTUs huggingface dataset:
Are new variants of psoriasis therapy (IL‐17 inhibitors) safe?

Psoriasis is a chronic, recurrent, inflammatory, and proliferative skin disease. Its etiology has not yet been fully assessed, but undoubtedly it is a multifaceted disease. The key role in its pathomechanism is played by genetic, immunologic, and environmental factors and stress. If traditional methods of psoriasis treatment (phototherapy, methotrexate, retinoids, cyclosporine A) fail, we reach for the following biopharmaceuticals – infliximab, etanercept, adalimumab, or ustekinumab. However, genetic engineering progress discovers new possibilities – the pending clinical trials involve IL‐17, IL‐23 antagonists, PDE4 and ‐3 and ‐1. Psoriasis etiopathogenesis mainly involves the IL‐17A, IL‐17F, and IL‐17A/F subtypes, which affect the keratinocytes. The biological therapy molecularly oriented with the antagonists of interleukin 17 is based mainly on the influence onto the cytokine in the manner that prevents it from binding with the receptor. Three biopharmaceuticals are currently under third phase studies: two fully humanized antibodies neutralizing IL‐17 – ixekizumab and secukinumab, and one human monoclonal antibody, brodalumab. The below work will be devoted to the analysis of possible undesirable symptoms, which were observed during the studies. We will try to review the latest literature concerning the most important clinical trials conducted in many centers.
Assessment of Water Handling and Sanitation Practices Among Rural Communities of Farta Woreda, Northwest Ethiopia

Worldwide, 663 million people do not have access to improved drinking water supplies and 2.5 billion people lack access to improved sanitation including one billion who practice open defecation. Eighty-eight percent of deaths from diarrheal diseases are attributable to unsafe water, inadequate sanitation, and insufficient hygiene practices. So this study is aimed at assessing water handling and sanitation practice among rural communities of Farta woreda, North West Ethiopia. A community based cross-sectional study was conducted in Farta Woreda in March 2014. A total of 834 households were proportionally allocated to 10 kebeles of the Woreda and selected by systematic random sampling technique. Data was collected using a pretested structured questionnaire. Descriptive analysis was performed to obtain the frequency distribution of the variables. The majority of respondents used unprotected spring 313 (37.5%) followed by protected spring 206 (24.7%) for all domestic use. Most respondents 382 (92.5%) had covered their stored water and practiced pouring method to withdraw water from the stored container. Majority 738 (88.5%) of households had access to water within a time of 30 minutes or less. House hold water treatment was not common in the study area, only 23 (2.8%) households practiced. About four hundred seventy eight (57.3%) households had latrine facility, of which 263 (55%) was open pit latrine. Of those households having latrine only 102 (21.3%) households had hand washing facility. This study revealed that most of the respondents had poor water handling and sanitation practice. Thus, it underscores that there should be great attention.
Cavity Catalysis by Cooperative Vibrational Strong Coupling of Reactant and Solvent Molecules

Abstract Here, we report the catalytic effect of vibrational strong coupling (VSC) on the solvolysis of para‐nitrophenyl acetate (PNPA), which increases the reaction rate by an order of magnitude. This is observed when the microfluidic Fabry–Perot cavity in which the VSC is generated is tuned to the C=O vibrational stretching mode of both the reactant and solvent molecules. Thermodynamic experiments confirm the catalytic nature of VSC in the system. The change in the reaction rate follows an exponential relation with respect to the coupling strength of the solvent, indicating a cooperative effect between the solvent molecules and the reactant. Furthermore, the study of the solvent kinetic isotope effect clearly shows that the vibrational overlap of the C=O vibrational bands of the reactant and the strongly coupled solvent molecules is critical for the catalysis in this reaction. The combination of cooperative effects and cavity catalysis confirms the potential of VSC as a new frontier in chemistry.
Perceived stress and coping skills of university student-athletes and the relationship with life satisfaction

Student-athletes are expected to cope with their studies and participation in sport simultaneously as well as to satisfy the expectations of coaches, teammates, friends, and family. Once student-athletes perceive a situation as stressful and struggle to cope with the anticipation thereof, their satisfaction with life will be negatively influenced. This study was conducted to determine the relationship between perceived stress and coping skills with satisfaction with life of university students-athletes. A purposive sample of 500 first, second and third year as well as post graduate university student-athletes competing at university, national, provincial and regional level were drawn. A questionnaire including the Perceived Stress Scale (PSS-10), the Satisfaction With Life Scale (SWLS), and the Athletic Coping Skills Inventory-28 (ACSI-28) were administered to the sample. Descriptive statistics, bivariate correlation analysis, and multiple linear regression analysis were used to report the results of the study. The results indicated that student-athletes were moderately satisfied with their life and perceived their stress as slightly higher than average. A negative significant relationship was found between perceived stress and satisfaction with life, as well as between perceived stress and five coping skills subscales (coping with adversity, goal setting/mental preparation, freedom from worry, confidence and achievement motivation, coachability). A positive significant relationship was found between satisfaction with life and the five coping skills subscales. This study concluded that student-athletes perceived stress level and two coping skills (freedom from worry and goal setting/mental preparation) were important and contribute significantly to their life satisfaction.
Tethered particle motion mediated by scattering from gold nanoparticles and darkfield microscopy

We measured light scattered from gold nanoparticles with darkfield microscopy in order to perform single molecule detection based on tethered particle motion (TPM). This combination results in a signal to noise ratio of about 40 dB, which allowed us to use 80 nm diameter gold particles as reporters instead of the typically used polystyrene particles whose sizes are up to 1 µm. The particle size is crucial in TPM experiments as it can induce a volume-exclusion effect, which results in a stretching force acting on the DNA tether. This affects both the biophysical and statistical properties of the anchored DNA and hence the interpretation of the experimental data. We demonstrated that the gold nanoparticles and darkfield microscopy can be used to characterize the confined Brownian motion of dsDNA-tethered gold particles with a spatial precision of 3 nm. Physical parameters such as the spring constant of the tethered DNA fragment and the persistence length can be derived from the two dimensional (2D) (x, y) projected image data. We have applied this method to various MgCl2 and glycerol concentrations as a proof of principle.
NeuroSAFE robot-assisted laparoscopic prostatectomy versus standard robot-assisted laparoscopic prostatectomy for men with localised prostate cancer (NeuroSAFE PROOF): protocol for a randomised controlled feasibility study

Introduction Robot-assisted laparoscopic prostatectomy (RALP) offers potential cure for localised prostate cancer but is associated with considerable toxicity. Potency and urinary continence are improved when the neurovascular bundles (NVBs) are spared during a nerve spare (NS) RALP. There is reluctance, however, to perform NS RALP when there are concerns that the cancer extends beyond the capsule of the prostate into the NVB, as NS RALP in this instance increases the risk of a positive surgical margin (PSM). The NeuroSAFE technique involves intraoperative fresh-frozen section analysis of the posterolateral aspect of the prostate margin to assess whether cancer extends beyond the capsule. There is evidence from large observational studies that functional outcomes can be improved and PSM rates reduced when the NeuroSAFE technique is used during RALP. To date, however, there has been no randomised controlled trial (RCT) to substantiate this finding. The NeuroSAFE PROOF feasibility study is designed to assess whether it is feasible to randomise men to NeuroSAFE RALP versus a control arm of ‘standard of practice’ RALP. Methods NeuroSAFE PROOF feasibility study will be a multicentre, single-blinded RCT with patients randomised 1:1 to either NeuroSAFE RALP (intervention) or standard RALP (control). Treatment allocation will occur after trial entry and consent. The primary outcome will be assessed as the successful accrual of 50 men at three sites over 15 months. Secondary outcomes will be used to aid subsequent power calculations for the definitive full-scale RCT and will include rates of NS; PSM; biochemical recurrence; adjuvant treatments; and patient-reported functional outcomes on potency, continence and quality of life. Ethics and dissemination NeuroSAFE PROOF has ethical approval (Regional Ethics Committee reference 17/LO/1978). NeuroSAFE PROOF is supported by National Institute for Healthcare Research Research for Patient Benefit funding (NIHR reference PB-PG-1216-20013). Findings will be made available through peer-reviewed publications. Trial registration number NCT03317990.
Association between Physical activity, Body composition and Cardiovascular Diseases in Non-athlete Male students

Cardiovascular diseases are major cause mortality and morbidity in Iran. Epidemiology studies have shown that non activity and obesity are the main factors for cardiovascular diseases (CVD). So study purpose is relationship between physical activity (PA), body composition and CVD risk factors in non-athlete students. Two Hundred non-athlete male students (age 21.33 ± 2.50yr, height 171.4 ± 6.44cm, Weight 70.80 ± 23.33kg) in Islamic Azad University–Dezful branch were require to filed out consent form, health history and Bouchard questionnaire. In this study Body weight (BW), body mass index (BMI), Body Fat (PBF), Waist hip ratio index (WHR), systolic blood pressure (SBP), diastolic blood pressure (DBP) was measured. Daily physical activity estimated with Bouchard questionnaire. To determine the serum lipid profiles, blood samples were obtained in fasting state. Statistical analyses were performed through the Statistical Package for the Social Sciences (SPSS/10). The association between PA, BW, BMI, WHR, PBF and the select CVD risk profile were performed using Pearson product moment coefficient of correlation. All data expressed as mean±sd. Statistical significance was set at the P< 0.05 levels. The results showed relationship between PA, body composition and some of coronary heart diseases risk factors. The results indicated that student’s health effected than PA and body fat because there was relation between PA, BFP and coronary heart disease risk factors.
Exploring Relationship between Brand Equity and Customer Loyalty on Pharmaceutical Market

By maintaining continuous satisfaction and high level of the brand's equity the customers express the intention of long-term buying of product and their choice spreads on Mother Products in the organization's portfolio. By developing a brand which represents value to the customers, the customers ’satisfaction will grow reinforcing relationship between satisfaction and brand development. Purpose of this paper is to obtain insight about the relationship between elements of brand equity and customer loyalty among self-medication products. The research results show that elements of brand equity do increase customer brand loyalty. But not all elements do contribute in the same manner.
Calibration of Dual-Polarization Radar in the Presence of Partial Beam Blockage

Abstract In the presence of partial beam blockage (PBB), weather radar measurements can experience significant bias that directly compromises the accuracy of the hydrologic applications. Techniques for the calibration of the radar reflectivity factor Z and differential reflectivity ZDR, measured with dual-polarization weather radars in the presence of partial beam obstruction, are examined in this paper. The proposed ZDR calibration technique utilizes radar measurements of ZDR in light rain and dry aggregated snow at unblocked and blocked elevations. This calibration technique was tested for the National Severe Storms Laboratory’s (NSSL’s) Cimarron radar that suffers from PBB, and a polarimetric prototype of the Weather Surveillance Radar-1988 Doppler (WSR-88D) that does not experience PBB. Results indicate that the ZDR bias that is associated with PBB can be calibrated with an accuracy of 0.2–0.3 dB, provided that the dataset is sufficiently large. Calibration of Z in the presence of PBB is based on the .
Searching for the impossible: Parapsychology's elusive quest.

Recently, American Psychologist published a review of the evidence for parapsychology that supported the general claims of psi (the umbrella term often used for anomalous or paranormal phenomena). We present an opposing perspective and a broad-based critique of the entire parapsychology enterprise. Our position is straightforward. Claims made by parapsychologists cannot be true. The effects reported can have no ontological status; the data have no existential value. We examine a variety of reasons for this conclusion based on well-understood scientific principles. In the classic English adynaton, "pigs cannot fly. " Hence, data that suggest that they can are necessarily flawed and result from weak methodology or improper data analyses or are Type I errors. So it must be with psi effects. What we find particularly intriguing is that, despite the existential impossibility of psi phenomena and the nearly 150 years of efforts during which there has been, literally, no progress, there are still scientists who continue to embrace the pursuit. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
The mode of delivery and some selected obstetric factors as predictors of post-partum depression

Background: The most prevalent mental or emotional problem associated with childbirth is postpartum depression (PPD). This study was designed to determine the psychological responses of Iranian women to difficult childbirth. Methods: In this prospective cohort design, incidence rate and associated obstetric predictors of PPD over twelve week’s post-partum were investigated among 1801 non depressed pregnant women attending primary health centers (PHCs) of Mazandaran province from January to June 2009 using the Iranian version of the Edinburgh Postnatal Depression Scale (EPDS > 12). Using logistic regression analyses, odds ratios (ORs) for the significant obstetric risk factors that were significantly associated with PPD from chi-square tests were calculated. The associations were controlled for possible socio-demographic confounding factors. Results: The incidence proportions of depression occurring over a 12 weeks period of post-partum were 12.30%. The regression model showed that the risk of PPD was increased by experienced recurrent urinary infection [OR=2.25, (95% CI: 1.15-4.38), unwanted pregnancy [OR=1.97, (95% CI: 1.15-3.35)] and gestational diabetes [OR=3.41, (95% CI=1.46-5.88)] during pregnancy. Conclusions: Although the mode of delivery was not predictive of PPD, other difficulties during pregnancy were associated with higher levels of depressive symptoms over 12 week's post-partum that needs on-time interventions.
Effects of Financial Deepening on Saving Mobilization: Evidence from African Countries

Purpose:The purpose of this paper is to investigate the impact of financial deepening proxied by Broad Money Supply as a percent of Gross Domestic Product and Domestic Credit to Private Sector as a percentage of Gross Domestic Product on savings proxied by Gross Domestic Savings as a percent of Gross Domestic Product in Africa over the period 1998 – 2015 Design/methodology/approach: The study uses panel data of forty-two (42) countries in Africa over the period 1998 – 2015 and the system generalized method of moments dynamic panel estimation framework. Findings: The paper finds an insignificantly positive relationship between Broad money supply and Gross Domestic Savings in Africa. However, the impact of Domestic Credit to Private Sector was negative and significant. This results indicate that financial deepening has not stimulated domestic resource mobilization in Africa. However, growth in per capita income had a significantly positive impact on Gross Domestic Savings which is consistent with the life cycle theory, increase in real interest rate negatively affected Gross Domestic Savings while increase in age dependency reduced Gross Domestic Savings. Practical implications: Policies should focus on deepening the financial sector since it has the tendency to impact positively on savings. Such polices should center on extending financial services to the rural areas through the provision of infrastructure such as roads, electricity as well as the development of innovative financial instruments that will attract the large informal sector. Reducing the fragmented nature of the market and the high transaction costs as well as balancing the dominance of the banking sector will help improve efficiency of the sector and consequently, its ability to mobilize resources. Pursuing growth-enhancing policies that focus on value addition to raw materials and the adoption of technology to ensue efficiency in production could result in higher productivity and consequently savings. Efforts should also focus on reducing interest rates since many Africans are net borrowers and thus increase in interest rate will increase the cost of borrowing which will have adverse impacts on savings. Originality/value: The paper offers significant value in shaping and improving the financial sector in Africa with the view to enhancing savings.
Evolution of sex ratio through gene loss

Significance Several species of Caenorhabditis nematodes, including Caenorhabditis elegans, have recently evolved self-fertile hermaphrodites from female/male ancestors. These hermaphrodites can either self-fertilize or mate with males, and the extent of outcrossing determines subsequent male frequency. Using experimental evolution, the authors show that a gene family with a historical role in sperm competition plays a large role in regulating male frequency after self-fertility evolves. By reducing, but not completely eliminating outcrossing, loss of the mss genes contributes to adaptive tuning of the sex ratio in a newly self-fertile species. The maintenance of males at intermediate frequencies is an important evolutionary problem. Several species of Caenorhabditis nematodes have evolved a mating system in which selfing hermaphrodites and males coexist. While selfing produces XX hermaphrodites, cross-fertilization produces 50% XO male progeny. Thus, male mating success dictates the sex ratio. Here, we focus on the contribution of the male secreted short (mss) gene family to male mating success, sex ratio, and population growth. The mss family is essential for sperm competitiveness in gonochoristic species, but has been lost in parallel in androdioecious species. Using a transgene to restore mss function to the androdioecious Caenorhabditis briggsae, we examined how mating system and population subdivision influence the fitness of the mss+ genotype. Consistent with theoretical expectations, when mss+ and mss-null (i.e., wild type) genotypes compete, mss+ is positively selected in both mixed-mating and strictly outcrossing situations, though more strongly in the latter. Thus, while sexual mode alone affects the fitness of mss+, it is insufficient to explain its parallel loss. However, in genetically homogenous androdioecious populations, mss+ both increases male frequency and depresses population growth. We propose that the lack of inbreeding depression and the strong subdivision that characterize natural Caenorhabditis populations impose selection on sex ratio that makes loss of mss adaptive after self-fertility evolves.
Adaptive control of nonlinear attitude motions realizing linear closed-loop dynamics

An adaptive attitude control law is presented that realizes linear closed-loop dynamics in the attitude error vector. The modified Rodrigues parameters (MRPs) are used as the kinematic variables since they are nonsingular for all possible rotations. The desired linear closed-loop dynamics can be of either PD or PID form. Only a crude estimate of the moment of inertia matrix is assumed to be known. An open-loop nonlinear control law is presented which yields linear closed-loop dynamics in terms of the MRPs. An adaptive control law is developed which asymptotically enforces these desired linear closed-loop dynamics in the presence of large inertia and external disturbance model errors. Since the unforced closed-loop dynamics are nominally linear, standard linear control methodologies can be employed to satisfy design requirements. The adaptive control law is shown to track the desired linear performance asymptotically without requiring a priori knowledge of either the inertia matrix or external disturbance.
APPLICATION OF PREHOSPITAL TRAUMA LIFE SUPPORT PRINCIPLES

The objective was to analyze the application of the Prehospital Trauma Life Support principles by the emergency medical teams. Observational study involving 100 care files of trauma victims during admission to an emergency medical service in April 2014. The prevalent cases of trauma victims were between 12 and 39 years of age (64%), with a predominance of male victims (69%). The teams applied the principles of Prehospital Trauma Life Support in most victims observed, but it was identified that 17% did not have their cervical and vertebral spine immobilized, the body remained immobilized using fixation belts in only 31% of the cases, injuries were unprotected in 15% of the victims and 63% were not undressed in search of injuries. It is highlighted that the emergency medical teams' application of the principles is fundamental to standardize actions through a logical sequence of universal care. Ongoing training is suggested for these teams, based on Prehospital Trauma Life Support. DESCRIPTORS: Emergency Medical Services; Trauma; Emergencies; Inservice training; Nursing.