Miracle-dz/UniFAR-FTUs huggingface dataset:
An Embedded Model of Cultural Adaptation in Global Teams

This research examines the process through which globally distributed work teams attempt to adapt to cross-cultural differences while being constrained by the local contexts in which they are embedded. We conducted an in-depth field study of nine software development teams that included 132 ethnographic initial interviews, periods of team observation, 19 follow-up interviews, and team meetings. Inductive analysis of the data led us to develop an embedded model of cultural adaptation in global teams to describe the process we observed as teams attempted to cope with important differences in interpersonal communication styles, preferred approaches to organizational control and authority relations, and work-related knowledge and problem-solving approaches. We show how local embeddedness and interdependence across sites together drive cultural adaptation dialectics as actors attempt to resolve rippling tensions within and across nested social structures. The model of cultural adaptation that we developed as an outcome of our research challenges literature that assumes adaptation can be contained within a team and is distinctive in incorporating a dynamic systems view of culture. We build on and develop theory concerning multilevel structuration dynamics. Our work may have implications for other types of boundary-spanning collaborations such as strategic alliances and multinational corporations.
Induction chemotherapy for larynx preservation: patient selection or therapeutic effect?

The role of chemotherapy as part of a larynx sparing treatment strategy for advanced laryngeal cancer has evolved considerably over the last 20 years. During the 1980s, no sort of chemotherapy—induction/neoadjuvant, concurrent, adjuvant, or any combination of these approaches— could be considered part of standard treatment. Partial laryngectomy and primary radiation were the recommended therapeutic options for patients hoping to avoid total laryngectomy. These approaches are still used in selected patients today. However, standard therapy for an advanced primary cancer of the larynx commonly entailed surgical removal of the voice box. The landmark Veterans Affairs’ (VA) laryngeal cancer study, 1 initially published in 1991, provided the best initial evidence to support cisplatin-based, induction chemotherapy as part of a larynx preserving treatment approach. The VA investigators randomized patients with stage III or IV laryngeal cancer to primary surgery and postoperative radiation versus three cycles of induction chemotherapy followed by radiation. Laryngectomy was reserved for patients with a less than major response after two cycles of chemotherapy, suspected disease persistence after radiation, or relapse. The chemotherapy/radiation arm yielded survival rates comparable to those achieved with primary surgical management. Two thirds of surviving patients retained their larynx. The similarly designed European Organisation for Research and Treatment of Cancer (EORTC) larynx preservation study, which focused on patients with advanced cancer of the hypopharynx, further supported the principles of the VA trial. 2 Induction chemotherapy followed by radiation with surgery reserved for salvage came to be considered a new standard treatment for patients with locally advanced cancer of the larynx. Subsequent studies, most prominently the Radiation Therapy
The influence of sleep complaints on the association between chronotype and negative emotionality in young adults

A great body of research indicates that eveningness is associated with negative psychological outcomes, including depressive and anxiety symptoms, behavioral dyscontrol and different health impairing behaviors. Impaired subjective sleep quality, increased circadian misalignment and daytime sleepiness were also reported in evening-type individuals in comparison with morning-types. Although sleep problems were consistently reported to be associated with poor psychological functioning, the effects of sleep disruption on the relationship between eveningness preference and negative emotionality have scarcely been investigated. Here, based on questionnaire data of 756 individuals (25.5% males, age range = 18–43 years, mean = 25.3 ± 5.8 years), as well as of the evening-type (N = 211) and morning-type (N = 189) subgroups, we examined the relationship among sleep problems, eveningness and negative emotionality. Subjects completed the Hungarian Version of the Horne and Östberg Morningness–Eveningness Questionnaire (MEQ-14), The Athen Insomnia Scale (AIS) and the Epworth Sleepiness Scale (ESS). Moreover, a composite score of Negative Emotionality (NE) was computed based on the scores of the Short Beck Depression Inventory (BDI-9), the Perceived Stress Scale (PSS-4) and the General Health Questionnaire (GHQ-12). Morning and evening circadian misalignment was calculated based on the difference between preferred and real wake- and bedtimes. Two possible models were tested, hypothesizing that sleep problems (circadian misalignment, insomniac symptoms and daytime sleepiness) moderate or mediate the association between eveningness and negative emotionality. Eveningness preference was correlated with increased NE and increased AIS, ESS and circadian misalignment scores. Our results indicate that eveningness-preference is an independent risk factor for higher negative emotionality regardless of the effects of age, gender, circadian misalignment and sleep complaints. Nevertheless, while chronotype explained ∼6%, sleep problems (AIS and ESS) accounted for a much larger proportion (∼28%) of the variance of NE. We did not find a significant effect of interaction (moderation) between chronotype and sleep problems. In contrast, insomniac symptoms (AIS) emerged as a partial mediator between chronotype and NE. These findings argue against the assumption that indicators of mental health problems in evening-type individuals can be explained exclusively on the basis of disturbed sleep. Nevertheless, negative psychological outcomes seem to be partially attributable to increased severity of insomniac complaints in evening-types.
Characterization of Metallically Bonded Carbon Nanotube-Based Thermal Interface Materials Using a High Accuracy 1D Steady-State Technique

The next generation of Thermal Interface Materials (TIMs) are currently being developed to meet the increasing demands of high-powered semiconductor devices. In particular, a variety of nanostructured materials, such as carbon nanotubes (CNTs), are interesting due to their ability to provide low resistance heat transport from device to spreader and compliance between materials with dissimilar coefficients of thermal expansion (CTEs). As a result, nano-Thermal Interface Materials (nTIMs) have been conceived and studied in recent years, but few application-ready configurations have been produced and tested. Over the past year, we have undertaken major efforts to develop functional nTIMs based on short, vertically-aligned CNTs grown on both sides of a thin interposer foil and interfaced with substrate materials via metallic bonding. A high-precision 1-D steady-state test facility has been utilized to measure the performance of nTIM samples, and more importantly, to correlate performance to the
Software Reliability Growth Models with Testing-Effort

Many software reliability growth models have been proposed in the past decade. Those models tacitly assume that testing-effort expenditures are constant throughout software testing. This paper develops realistic software reliability growth models incorporating the effect of testing-effort. The software error detection phenomenon in software testing is modeled by a nonhomogeneous Poisson process. The software reliability assessment measures and the estimation methods of parameters are investigated. Testing-effort expenditures are described by exponential and Rayleigh curves. Least-squares estimators and maximum likelihood estimators are used for the reliability growth parameters. The software reliability data analyses use actual data. The software reliability growth models with testing-effort can consider the relationship between the software reliability growth and the effect of testing-effort. Thus, the proposed models will enable us to evaluate software reliability more realistically.
Insights into hydroxyl measurements and atmospheric oxidation in a California forest

Abstract. The understanding of oxidation in forest atmospheres is being challenged by measurements of unexpectedly large amounts of hydroxyl (OH). A significant number of these OH measurements were made by laser-induced fluorescence in low-pressure detection chambers (called Fluorescence Assay with Gas Expansion (FAGE)) using the Penn State Ground-based Tropospheric Hydrogen Oxides Sensor (GTHOS). We deployed a new chemical removal method to measure OH in parallel with the traditional FAGE method in a California forest. The new method gives on average only 40–60% of the OH from the traditional method and this discrepancy is temperature dependent. Evidence indicates that the new method measures atmospheric OH while the traditional method is affected by internally generated OH, possibly from oxidation of biogenic volatile organic compounds. The improved agreement between OH measured by this new technique and modeled OH suggests that oxidation chemistry in at least one forest atmosphere is better understood than previously thought.
Effects of Academic Stress and Perceived Social Support on the Psychological Wellbeing of Adolescents in Ghana

The purpose of this study was to examine how academic stress and perceived social support influence the psychological wellbeing of Senior High School students in Ghana. Two hundred and twenty six male and female students participated. The general health questionnaire, student life-stress inventory and perceived social support from family and friends scales were used to assess psychological wellbeing, academic stress and perceived social support respectively. The results indicated that perceived social support buffered the effects of academic stress on psychological wellbeing. Girls reported higher scores on perceived social support but reported more depression. Boys reported higher academic stress and better psychological wellbeing, and these have been attributed partly to the socialisation role of gender. These results have policy implications in respect of the creation of a cordial school environment as well as encouraging a healthy interpersonal relationship between adolescents and their family and friends with the aim of reducing academic stress appraisal which is inimical to the psychological wellbeing of adolescents.
Complementarity of visual and voxel-based FDG-PET analysis to detect MCI-like hypometabolic pattern in elderly patients with hypertension and isolated memory complaints

Background 18F-FDG PET can be used to aid in the diagnosis of Alzheimer’s disease (AD) and clarify the diagnosis and prognosis of patients with mild cognitive impairment (MCI). Purpose To compare the results of a quantitative analysis of FDG-PET brain images to a standard visual analysis (SVA) with regards to the detection of MCI-like hypometabolic pattern in elderly patients with hypertension and subjective, isolated memory complaints. Material and Methods FDG-PET brain was performed in 71 patients (mean age, 76.4 ± 5.1 years; women, 53.5%). Images were analyzed for the presence of an MCI-like hypometabolic pattern using an SVA by 2 physicians and a voxel-based statistical procedure (statistical parametric mapping [SPM]) that compared each patient’s images to normal reference samples from 19 elderly individuals obtained using the same PET camera. The reliability of these analyses was evaluated according to neuropsychological assessment results, including the Grober & Buschke Free and Cued Selective Reminding Test, and a combined analysis by a neuropsychologist. Results An MCI-like hypometabolic pattern was documented in 5 patients (7%) by SVA and 7 patients (10%) by SPM analysis; however, only 2 of these patients were selected by both methods. The group characteristics of the 7 patients identified by the quantitative method were consistent with the MCI pattern, which included a higher rate of abnormal GB-FCSRT in Free Recall (57% vs. 9%, p < 0.05) or in Total Recall (29% vs. 8%, p < 0.05) when compared with other patients. In contrast, the group identified by SVA did not exhibit these characteristics. Conclusion A combined visual and quantitative analysis improves the diagnostic accuracy to detect an MCI-like hypometabolic pattern in elderly patients with hypertension and subjective, isolated memory complaints.
Efficacy of Albendazole and Two Different Doses of Paromomycin for Treatment of Naturally Occurring Giardia Infection in Lambs

Summary Giardia duodenalis is a protozoan that infects a variety of vertebrates. It is a major cause of diarrhea in agricultural animals. There have been reports of clinical signs in cattle and sheep, which include diarrhea, dehydration and weight loss, however; there are limited drugs available for the treatment of giardiasis in animals. In this study, we compared the therapeutic effect of 20 mg albendazole, 50 mg and 100 mg paromomycin (kg body weight orally) for 3 successive days in lambs naturally infected with giardiasis. The efficacy of these drugs was evaluated based on reduction in cyst excretion. In the group treated with albendazole, no cysts were seen in the feces after treatment on D5 (day 5) in 7 lambs and on D8 in all animals. In the group treated with 50mg/kg of paromomycin, no cysts were seen in the feces after treatment on D2 in 3 lambs and on D6 in all animals. In the group treated with 100 mg/kg of paromomycin, there were no cysts after treatment on D2 in 5 lambs and on D6 in all of lambs. White blood cell (WBC) levels were high in all groups before treatment; paromomycin decreased the total leukocyte count more than albendasole. In the present study, we found paromomycin to be more effective than albendozole for the treatment of lambs with giardiasis for both treatment regiments mentioned above.
Dexmedetomidine improves neurologic outcome from incomplete ischemia in the rat. Reversal by the alpha 2-adrenergic antagonist atipamezole.

Dexmedetomidine is an alpha 2-adrenergic agonist that decreases central sympathetic activity and reduces the anesthetic requirement for halothane. We evaluated the effect of dexmedetomidine on neurologic and histopathologic outcome from incomplete cerebral ischemia in the rat. Anesthesia was maintained with a 25-micrograms.kg-1.h-1 fentanyl infusion combined with 70% nitrous oxide. Incomplete ischemia was produced by unilateral carotid artery ligation combined with hemorrhagic hypotension to 35 mmHg for 30 min. Arterial blood gas tensions, pH, and head temperature were maintained at normal levels during the experiment. Four ischemic groups were tested: group 1 (n = 15) received an intraperitoneal (ip) saline injection (control); group 2 (n = 10) received an ip injection of 10 micrograms/kg dexmedetomidine 30 min before ischemia; group 3 (n = 10) received 100 micrograms/kg dexmedetomidine; and group 4 (n = 10) received 100 micrograms/kg dexmedetomidine plus 1 mg/kg atipamezole (an alpha 2-adrenergic antagonist). Neurologic outcome was evaluated for 3 days using a graded deficit score. Histopathology was evaluated in coronal section in caudate and hippocampal tissue segments. Dexmedetomidine (10 and 100 micrograms/kg) significantly decreased plasma catecholamines and improved neurologic and histopathologic outcome in a dose-dependent manner compared to control rats (P less than 0.05). Atipamezole abolished the decrease in catecholamines and the improvement in outcome seen with dexmedetomidine, confirming that these effects were mediated by alpha 2-adrenergic receptors. It is concluded that alpha 2-adrenoreceptor stimulation decreases sympathetic activity and decreases ischemic injury in a model of incomplete cerebral ischemia.
Incidence of hypertension and risk of cardiovascular events among ethnic Chinese: report from a community-based cohort study in Taiwan

Background Hypertension confers risk on cardiovascular events; however, less is known concerning hypertension incidence among ethnic Chinese. The effect of prehypertension on new onset of hypertension and cardiovascular events is also unknown. Objectives To investigate the incidence of hypertension, risk factors and cardiovascular events in Taiwan. Design A prospective community-based cohort design. Setting and participants The Chin-Shan Community Cardiovascular Cohort consisted of 1703 men and 1899 women aged 35 years old and above, of homogeneous Chinese ethnicity, from 1990 to 2005. Main outcome measures Hypertension incidence rates, cardiovascular events. Results The patterns of adjusted cumulative incidence probability were curvilinear, increasing from 1% in the first period to 27% in the fourth period in normotensive subjects. The patterns among prehypertensives were from 4% in the first period to 59% in the fourth period. Women had an 18% lower risk of developing hypertension than men. The survival curves were distinctly different for different blood pressure categories (P < 0.001). Baseline blood pressure categories played important roles in predicting cardiovascular risks; the hazard risks of prehypertension and hypertension increased from 1.73 to 4.52, compared with baseline normotensive subjects. Conclusion The hypertension incidence rates among ethnic adult Chinese were high and were associated with obesity and metabolic syndrome status. Furthermore, the baseline prehypertension elicited significant risk of cardiovascular events in the community.
Success Factors for Strategic Change Initiatives: A Qualitative Study of Healthcare Administrators' Perspectives

EXECUTIVE SUMMARY Success factors related to the implementation of change initiatives are well documented and discussed in the management literature, but they are seldom studied in healthcare organizations engaged in multiple strategic change initiatives. The purpose of this study was to identify key success factors related to implementation of change initiatives based on rich qualitative data gathered from health leader interviews at two large health systems implementing multiple change initiatives. In‐depth personal interviews with 61 healthcare leaders in the two large systems were conducted and inductive qualitative analysis was employed to identify success factors associated with 13 change initiatives. Results from this analysis were compared to success factors identified in the literature, and generalizations were drawn that add significantly to the management literature, especially to that in the healthcare sector. Ten specific success factors were identified for the implementation of change initiatives. The top three success factors were (1) culture and values, (2) business processes, and (3) people and engagement. Two of the identified success factors are unique to the healthcare sector and not found in the literature on change models: service quality and client satisfaction (ranked fourth of 10) and access to information (ranked ninth). Results demonstrate the importance of human resource functions, alignment of culture and values with change, and business processes that facilitate effective communication and access to information to achieve many change initiatives. The responses also suggest opportunities for leaders of healthcare organizations to more formally recognize the degree to which various change initiatives are dependent on one another.
Prebiotics affect nutrient digestibility but not faecal ammonia in dogs fed increased dietary protein levels

An increased protein content and less digestible protein sources in the diet can induce bad faecal odour. The present study investigated the effect of adding prebiotics to dog diets enriched with animal-derived protein sources on apparent digestibilities and faecal ammonia concentration. In three subsequent periods eight healthy beagle dogs were fed a commercial dog diet that was gradually supplemented by up to 50 % with meat and bone meal (MBM), greaves meal (GM) or poultry meal (PM) respectively. Afterwards, 3 % fructo-oligosaccharides or 3 % isomalto-oligosaccharides were substituted for 3 % of the total diet. Supplementation with animal-derived protein sources did not decrease the apparent N digestibility significantly but oligosaccharides did. On the other hand the bacterial N content (% DM) in the faeces was highest in the oligosaccharide groups followed by the protein-supplemented groups and lowest in the control groups. When the apparent N digestibility was corrected for bacterial N no significant differences were noted anymore except for the GM group where the corrected N digestibility was still lower after oligosaccharide supplementation. The amount of faecal ammonia was significantly increased by supplementing with protein or oligosaccharides in the MBM and GM groups but not in the PM group. When apparent N digestibility is interpreted, a correction for bacterial N should be taken into account, especially when prebiotics are added to the diet. Oligosaccharides did not reduce the faecal ammonia concentrations as expected.
The Cytotoxic Enterotoxin of Aeromonas hydrophila Is Aerolysin

The channel-forming toxin aerolysin was identified 25 years ago by Bernheimer and Avigad ([1][1]), who gave the protein its name. Aerolysin was purified by Buckley et al. ([2][2]), and its structural gene, named aerA , was cloned and sequenced almost simultaneously by two groups ([6][3], [7][4]).
Intensified and high-dose chemotherapy with granulocyte colony-stimulating factor and autologous stem-cell transplantation support as first-line therapy in high-risk diffuse large-cell lymphoma.

PURPOSE In our previous study with MACOPB, we identified a high-risk group of patients with a poor 3-year survival rate of 29%. These patients were defined as having at diagnosis advanced-stage disease with high tumor burden (TB) and elevated lactate dehydrogenase (LDH) level or bone marrow (BM) involvement. A novel therapeutic scheme was investigated to improve the outcome of these patients. PATIENTS AND METHODS Fifty patients with high-risk diffuse large-cell lymphoma (DLCL) were enrolled. The therapeutic scheme includes three phases: induction with 8 weeks of MACOPB; intensification with a 3-day course of mitoxantrone 8 mg/m2 plus high-dose cytarabine (HDARA-C) 2 g/m2 every 12 hours plus dexamethasone 4 mg/m2 every 12 hours (MAD protocol) and granulocyte colony-stimulating factor (G-CSF) 5 microg/kg on days 4 to 17 to harvest peripheral-blood progenitor cells (PBPC); consolidation with carmustine (BCNU), etoposide, ARA-C, and melphalan (BEAM) regimen; plus autologous stem-cell transplantation (ASCT) with PBPC, marrow, or both. RESULTS Thirty-six patients (72%) achieved a complete response (CR), 11 (22%) showed no response (NR), and three (6%) died of toxicity. Among the 22 PRs or NRs after the induction phase, 56% of patients achieved a CR with subsequent intensified therapy. With a median follow-up duration of 32 months, the overall survival and failure-free survival rates were 56% and 50%, respectively. The disease-free survival rate is 69% at 32 months. Leukapheresis after MAD and G-CSF yielded a median of 32 x 10(6)/kg CD34+ cells and 80 x 10(4)/kg granulocyte-macrophage colony-forming units (CFU-GM). Thirty-nine patients were autografted and 11 did not undergo ASCT: six because of disease progression, four due to toxicity, and one because of patient refusal. The median times to achieve engrafment were 11 days (range, 7 to 19) to a neutrophil count greater than 0.5 x 10(9)/L and 12 days (range, 8 to 60) to a platelet count greater than 50 x 10(9)/L. CONCLUSION This sequential scheme with intensified and high-dose chemotherapy with ASCT is feasible with moderate toxicity and may improve the outcome in high-risk DLCL.